gebhart/patrepeval huggingface dataset:
Analgesics--I. 4-Acyloxy-3,4-Diphenyl-1-Methylpiperidines (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalgesics--I. 4-Acyloxy-3,4-Diphenyl-1-MethylpiperidinesArthur A. Patchett and Fred F. GiarrussoCite this: J. Med. Chem. 1961, 4, 2, 385–392Publication Date (Print):September 1, 1961Publication History Published online1 May 2002Published inissue 1 September 1961https://pubs.acs.org/doi/10.1021/jm50018a011https://doi.org/10.1021/jm50018a011research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A novel realization of signal processing to improve the precision of the open-loop IFOG (2005)

With the development of the technique of the digital signal processor, the using of digital signal processor in the open loop IFOG (interferometric fiber optic gyroscope) signal processing brings a great improvement of the performance of IFOG, especially in the technique of digital filtering, acquisition the values of arcsine and inverse tan function. The traditional way to get the values of inverse tan function is linear interpolation technique in digital signal circuit. This article put forward a new way to acquire the values of inverse tan function, the proportion of the second order Bessel function to the first order Bessel function and the proportion of the fourth order Bessel function to the second order Bessel function by using of the virtue of DSP, high speed of data processing. The fundamental, second and fourth harmonic signals from photoelectrical detector are sampled and demodulated by analog circuit. Then the signals from analog circuit are sampled into DSP by a 24-bit analog-to-digital converter, which is used to improve the dynamical range of the system. Then DSP computes the values mentioned above by polynomial approach. The simulation in Mathematic and Microsoft Visual C++ 6.0 proved that the method of polynomial approach to the functions has higher precision compared to the method of linear interpolation. Meanwhile the designed circuit shows it can meet the demand of real time data process. The tested results of designed circuit prove it has a great improvement in the dynamic range and precision of IFOG.
Growth retardation and increased apoptosis in mice with homozygous disruption of the <i>akt1</i> gene (2001)

The serine/threonine kinase Akt has been implicated in the control of cell survival and metabolism. Here we report the disruption of the most ubiquitously expressed member of the akt family of genes, akt1, in the mouse. Akt1(-/-) mice are viable but smaller when compared to wild-type littermates. In addition, the life span of Akt1(-/-) mice, upon exposure to genotoxic stress, is shorter. However, Akt1(-/-) mice do not display a diabetic phenotype. Increased spontaneous apoptosis in testes, and attenuation of spermatogenesis is observed in Akt1(-/-) male mice. Increased spontaneous apoptosis is also observed in the thymi of Akt1(-/-) mice, and Akt1(-/-) thymocytes are more sensitive to apoptosis induced by gamma-irradiation and dexamethasone. Finally, Akt1(-/-) mouse embryo fibroblasts (MEFs) are more susceptible to apoptosis induced by TNF, anti-Fas, UV irradiation, and serum withdrawal.
Systematization of Integrated Motion Control of Ground Vehicles (2015)

This paper gives an extended analysis of automotive control systems as components of the integrated motion control (IMC). The cooperation of various chassis and powertrain systems is discussed from a viewpoint of improvement of vehicle performance in relation to longitudinal, lateral, and vertical motion dynamics. The classification of IMC systems is proposed. Particular attention is placed on the architecture and methods of subsystems integration.
Crystal Structure of Phosphate Binding Protein Labeled with a Coumarin Fluorophore, a Probe for Inorganic Phosphate<sup>,</sup> (1998)

Crystal structures are presented for the A197C mutant of Escherichia coli phosphate binding protein (PBP) and the same mutant labeled at Cys197 with N-[2-(1-maleimidyl)ethyl]-7-(diethylamino)coumarin-3-carboxamide (MDCC). Both proteins are complexed with inorganic phosphate. The latter molecule, MDCC-PBP, exhibits a large increase in fluorescence on binding inorganic phosphate. The resulting high-fluorescence state of the coumarin and the ability of this coumarin to monitor the conformational changes associated with inorganic phosphate binding are interpreted in terms of the specific interactions of MDCC with the protein. The structure helps to explain why this particular label gives a high-fluorescence state on binding inorganic phosphate, while several other related labels do not, and hence aids our general understanding of environmentally sensitive fluorescence probes on proteins.
A high-throughput microfluidic single-cell screening platform capable of selective cell extraction (2015)

Microfluidic devices and lab-on-a-chip technologies have been extensively used in high-throughput single-cell analysis applications using their capability to precisely manipulate cells as well as their microenvironment. Although significant technological advances have been made in single-cell capture, culture, and analysis techniques, most microfluidic systems cannot selectively retrieve samples off-chip for additional examinations. Being able to retrieve target cells of interest from large arrays of single-cell culture compartments is especially critical in achieving high-throughput single-cell screening applications, such as a mutant library screening. We present a high-throughput microfluidic single-cell screening platform capable of investigating cell properties, such as growth and biomolecule production, followed by selective extraction of particular cells showing desired traits to off-chip reservoirs for sampling or further analysis. The developed platform consists of 1024 single-cell trapping/culturing sites, where opening and closing of each trap can be individually controlled with a microfluidic OR logic gate. By opening only a specific site out of the 1024 trapping sites and applying backflow, particular cells of interest could be selectively released and collected off-chip. Using a unicellular microalga Chlamydomonas reinhardtii, single-cell capture and selective cell extraction capabilities of the developed platform were successfully demonstrated. The growth profile and intracellular lipid accumulation of the cells were also analyzed inside the platform, where 6-8 hours of doubling time and on-chip stained lipid bodies were successfully identified, demonstrating the compatibility of the system for cell culture and fluorescent tagging assays.
PNUTS in Flight: Web-Scale Data Serving at Yahoo (2011)

Data management for stateful Web applications is extremely challenging. Applications must scale as they grow in popularity, serve their content with low latency on a global scale, and be highly available, even in the face of hardware failures. This need has generated a new class of Internet-scale data management systems. Yahoo has more than 100 user-facing applications and numerous internal platforms. To meet its data management needs, it built the PNUTS system. Here, the authors review PNUTS' growing adoption, point to specific applications, and detail several of PNUTS' features.
Subcutaneous and intrabursal administration of an LRH agonist to the pregnant hemicastrated rat during preimplantation. (1984)

A single injection of the LRH agonist, Wy-40,972, under the right ovarian bursa (IB) on any individual day (D) 1-7 in the pregnant rat increased still further the compensatory ovarian weight gain produced by hemicastration (HC) alone. Conversely, a single subcutaneous (sc) injection during the same period abolished the compensatory hypertrophy and reduced the weight of the remaining ovary to that of the ovary of the intact rat and below. The single sc or IB injections of Wy-40,972 were most effective in delaying implantation when administered on D3-4 or 4, respectively. Subcutaneous administration on D5, 6, or 7 produced an antifertility effect, whereas IB administration on any of these 3 days failed to modify the pregnancy. These data demonstrate that the LRH agonist, Wy-40,972, acts directly on the ovary with regard to both weight increase and delay of blastocyst implantation. The results are discussed in relation to hormonal requirements for implantation and desensitization of the ovary.
Identification of the neurofibromatosis type 1 gene product. (1991)

The gene for neurofibromatosis type 1 (NF1) was recently identified by positional cloning. The complete cDNA encodes a polypeptide of 2818 amino acids. To study the NF1 gene product, antibodies were raised against both fusion proteins and synthetic peptides. Initial characterization of two anti-peptide antibodies and one fusion-protein antibody demonstrated a specific protein of approximately 250 kDa by both immunoprecipitation and immunoblotting. This protein was found in all tissues and cell lines examined and is detected in human, rat, and mouse tissues. To demonstrate that these antibodies specifically recognize the NF1 protein, additional fusion proteins containing the sequence specific to the synthetic peptide were generated. Both peptide antisera recognize the proper specific fusion proteins so generated. Immunoprecipitates using the peptide antisera were shown to recognize the same protein detected by immunoblotting with either the other peptide antiserum or the fusion-protein antiserum. Immunoblotting using antiserum specific to spatially distinct epitopes conducted on tissue homogenates demonstrated the NF1 protein in all adult tissues. Based on the homology between the NF1 gene product and members of the GTPase-activating protein (GAP) superfamily, the name NF1-GAP-related protein (NF1GRP) is suggested.
Laser-Induced Forward Transfer of Functional Materials: Advances and Future Directions (2014)

Laser direct-write (LDW) techniques based on laser-induced forward transfer (LIFT) of functional materials offer unique advantages and capabilities for the rapid prototyping of electronic, optical and sensor elements as opposed to other digital printing processes like inkjet. LIFT processes have been applied to the fabrication of a wide variety of microelectronic elements such as interconnects, passive components, antennas, sensors, power sources and embedded circuits. Overall, LDW techniques are highly adaptable digital microfabrication processes in terms of materials versatility, substrate compatibility and range of writing speed, scale and resolution. This article will describe the unique advantages and capabilities of LIFT-based processes when used in conjunction with fluids and nanopastes, discuss their applications and consider their future for printing electronics.
Stimulus Specificity of Phase-Locked and Non-Phase-Locked 40 Hz Visual Responses in Human (1996)

Considerable interest has been raised by non-phase-locked episodes of synchronization in the gamma-band (30-60 Hz). One of their putative roles in the visual modality is feature-binding. We tested the stimulus specificity of high-frequency oscillations in humans using three types of visual stimuli: two coherent stimuli (a Kanizsa and a real triangle) and a noncoherent stimulus ("no-triangle stimulus"). The task of the subject was to count the occurrences of a curved illusory triangle. A time-frequency analysis of single-trial EEG data recorded from eight human subjects was performed to characterize phase-locked as well as non-phase-locked high-frequency activities. We found in early phase-locked 40 Hz component, maximal at electrodes Cz-C4, which does not vary with stimulation type. We describe a second 40 Hz component, appearing around 280 msec, that is not phase-locked to stimulus onset. This component is stronger in response to a coherent triangle, whether real or illusory: it could reflect, therefore, a mechanism of feature binding based on high-frequency synchronization. Because both the illusory and the real triangle are more target-like, it could also correspond to an oscillatory mechanism for testing the match between stimulus and target. At the same latencies, the low-frequency evoked response components phase-locked to stimulus onset behave differently, suggesting that low- and high-frequency activities have different functional roles.
A voltage down converter with submicroampere standby current for low-power static RAMs (1992)

A submicroampere standby current voltage downconverter (VDC) for high-density, low-power static RAMs is described. The current consumption of the VDC in standby mode can be decreased by using a novel low-current and temperature-independent current source circuit. The total current is less than 0.5 mu A at external voltage ranging from 3 to 5 V and at temperatures ranging from -20 to 80 degrees C. The voltage-follower circuits for standby and operation modes are stable despite the low current consumption in the standby mode. The phase margin of the voltage follower for standby mode is 50 degrees , and that for operation mode is 90 degrees . This indicates that the VDC is a promising circuit for battery-backup and high-density static RAMs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Superlattice cascade solar cell (1982)

This paper reports progress toward realization of a new cascade solar cell structure whose chief advantages over other present concepts are: use of silicon for the substrate and low bandgap cell; avoidance of the necessity of lattice matching; and incorporation of a GaAs/GaP superlattice to enhance efficiency and provide a low-resistance connecting junction. Details of the design and operation of an OMCVD system for growing this structure are presented. Results of experiments to optimize layer thickness, compositional uniformity, and surface morphology are described.
Studies on the .ALPHA.-glucoside hydrolase inhibitor, adiposin. III. .ALPHA.-Glucoside hydrolase inhibitory activity and antibacterial activity in vitro. (1982)

Adiposin-1 and -2 exhibited potent inhibitory activities against alpha-amylase, human salivary alpha-amylase and disaccharidases isolated from porcine small intestine. The effect of adiposin-1 and -2 on hydrolysis of glucoamylase was non-competitive. Adiposin showed antimicrobial activities against some Gram-positive bacteria, Gram-negative bacteria belonging to Enterobacteriaceae, Some anaerobic bacteria and some phytopathogenic fungi, and showed a synergistic effect on the antibacterial activity with some maltooligosaccharides. However, these antibacterial activities were suppressed by addition of various other saccharides.
The ion parametric resonance model predicts magnetic field parameters that affect nerve cells (1995)

An ion parametric resonance (IPR) model recently developed by Blanchard and Blackman predicts distinct magnetic field interactions with biological systems based on a selective relation among four factors: the flux density of the static magnetic field, the frequency and flux density (Bac) of the parallel ac magnetic field, and the charge-to-mass ratio of ions of biological relevance. To test this model, PC-12 cells stimulated by nerve growth factor to produce neurites were exposed for 23 h in a 5% CO2 incubator using a multiple-coil exposure system to produce 45 Hz ac and dc (366 mG parallel to ac; less than 2 mG perpendicular to ac) magnetic fields. Our earlier work showed a cycle of inhibition/no inhibition of neurite outgrowth consistent with the IPR model predictions for Bac exposures between 0 and 468 mG rms. The work described here tests neurite outgrowth over a broader range of Bac (233-1416 mG rms). The experimental results remain consistent with earlier results, and with IPR model predictions of a second cycle of inhibition, return to control values, followed by a third cycle of inhibition of neurite outgrowth. These responses support the fundamental relationships predicted by the IPR model. The results have broad significance for biology.
Optimization-based inter-utility power purchases (1994)

Power transactions are important activities among electric utility companies. Effective transaction decisions can result in significant savings since marginal generation costs of neighboring utilities could be quite different. Transactions, however, are coupled with the scheduling of units through system demand and reserve requirements, and are confined by many accustomed rules. How to make effective transaction decisions is therefore a very difficult problem. In this paper, an optimization-based method for the integrated consideration of power purchase transactions and the scheduling of thermal units is presented based on the augmented Lagrangian decomposition and coordination method. Numerical testing results based on modified Northeast Utility's data show that the proposed algorithm is efficient, and significant savings can be obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
High Piezoelectric Longitudinal Coefficients in Sol–gel <scp>PZT</scp> Thin Film Multilayers (2014)

A five‐layer stack of lead zirconate titanate ( PZT ) thin films with Pt electrodes was fabricated for potential applications in nanoactuator systems. The 1 μm thick PZT films were deposited by a sol–gel technique, the platinum electrodes by sputtering. The PZT films were crack‐free, in spite of the use of silicon as a substrate, suggesting an increased toughness of the metal–ceramic composite. For piezoelectric characterization, the intermediate electrodes were liberated by successive etching of the PZT and Pt layers, obtaining a functional three‐ layer stack. A total thickness change of 5.2 nm was achieved with 10 V, measured by double beam laser interferometry. The small signal response was obtained as 0.49 nm/V. Finite element simulations were made to account for the thickness change in the substrate due to the transverse piezoelectric effect. The average response corresponds to an average d 33,f of 120 pm/V. The multiple annealed buried layers show clearly a better performance with up to 175 pm/V. It is concluded that the electrode interfaces in the interior exhibit higher qualities, as supported by transmission electron microscopy, and that the multiple anneals were beneficial for PZT thin film quality.
Assessing bacterial burden in wounds: comparing clinical observation and wound swabs (2010)

A randomised controlled trial (RCT) was conducted to compare the efficacy of nanocrystalline silver and cadexomer iodine dressings in healing chronic lower leg ulcers. The relationships between wound swab culture results and nurses' clinical assessments of critical colonisation, and between bacterial burden and healing rate, were also examined. There were 281 individuals with leg ulcers recruited. The bacterial burden of wounds was assessed using semi-quantitative wound swabs collected at baseline and intervals during the study. The study found no relationship between the nurses' clinical assessments and bacterial burden as identified from wound swabs in the wounds. A significant difference in wound healing was found with the use of nanocrystalline silver as compared to cadexomer iodine in the first 2 weeks of treatment when nil or low levels of leukocytes, gram positive bacilli, gram positive cocci or gram negative cocci were reported. This study has raised a number of questions regarding the need for further investigation into methods of assessing wound bacterial burden as well as the impact of wound biofilms on wound assessment and treatment.
New diagnostic, staging, and therapeutic aspects of early breast cancer (1990)

Many advances have occurred in breast cancer through research and clinical trials. More confidence in new biological consumptions about invasive breast cancer indicate that: (1) details of the primary breast cancer do not control survival; (2) breast-only failures after local excision do not bias against survival; and (3) cancer cell dissemination occurs at the same time via both lymphatic and hematogenous routes. Early detection with mammographic screening has indicated a greater number of smaller breast cancers, including sharp increases in ductal carcinoma in situ (DCIS). With proper analysis and control, DCIS of limited extent can be treated by local excision with or without radiation. Invasive breast cancer of limited extent can frequently be managed by lumpectomy and radiation therapy with survival rates equivalent to the more traditional mastectomy. Patient desires regarding breast preservation and quality of life are paramount. Risk: benefit analyses for individual patients need to be emphasized in issues of breast preservation and in selecting adjuvant therapy, both regional (radiotherapy) and systemic (chemotherapy) and hormonal therapy). We are entering an era of highly selective therapy based on more sophisticated analysis of the primary cancer. In the future, not only statistical predictions of outcome as achieved by flow cytometry, for example, will be more widely used, but individual prognostic factors may be developed such as with oncogene expression. Such individual prognostic factors will enable more selective therapy.
180° Unidirectional Bond Rotation in a Biaryl Lactone Artificial Molecular Motor Prototype (2006)

A bifunctional biaryl lactone has been synthesized that should be capable of iterative unidirectional aryl-aryl bond rotation via: (1) a diastereoselective lactone ring opening, (S)-1 to (P,S)-2 or (M,S)-2; (2) a chemoselective lactonization, (P,S)-2 or (M,S)-2 to (S)-3; and (3) a chemoselective hydrolysis, (S)-3 to (S)-1. Preliminary results of a racemic sample have indicated unidirectional 180 degrees rotation with very high directional selectivity per individual artificial molecular motor molecule through the first two steps of this sequence. [reaction: see text]
Oriented Films of Porous Coordination Polymer Prepared by Repeated in Situ Crystallization (2008)

Oriented films of porous coordination polymer CPL-1 are obtained on various substrates by repeated in situ crystallization. This method combining the concepts of the conventional in situ crystallization and the secondary growth can provide increased seed crystals on the substrates for the further growth, leading to the continuous films.
Politics, Economics, and Investment: Explaining Plant and Equipment Spending by U.S. Direct Investors in Argentina, Brazil, and Mexico (1994)

Few economists or laymen would deny that political events can have an important, sometimes even overwhelming, impact on economic decisions in general, and investment decisions in particular. The first goal of this paper was to integrate a number of political and non-traditional economic variables into the standard theory of investment based on the maximization of the expected value of the firm. The second goal was to test this generalized investment theory on a particularly fertile field for gauging the interaction of political and economic factors: the plant and equipment spending of foreign manufacturing affiliates of U.S. multinationals in Argentina, Brazil, and Mexico. The results of these tests show that the generalized theory is far superior to the traditional alternatives in explaining the real investment of the sample for the 1958-89 period.