gebhart/patrepeval huggingface dataset:
[Effect of valve type and valve function on chronic intravascular hemolysis after alloprosthetic mitral and aortic valve replacement]. (1983)

In 1091 patients with isolated Björk-Shiley, Lillehei-Kaster, Starr-Edwards, and St. Jude Medical mitral and aortic valve replacement, hemolysis parameters were determined (hemoglobin, LDH, haptoglobin, free plasma hemoglobin, reticulocyte count, serum bilirubin, transferrin, urine hemosiderin, schistocyte count). In 1006 of these patients no valve dysfunction was detected, while in 85 patients either paravalvular leakage or a thrombosis of the prosthetic valve was present. Haptoglobin was the most sensitive parameter for detecting even mild intravascular hemolysis, which was present in two-thirds of patients after alloprosthetic heart valve replacement. For quantifying red cell damage LDH was useful. Hemolysis was somewhat higher after Lillehei-Kaster and Starr-Edwards than after Björk-Shiley or St. Jude Medical implantation. The variance of LDH levels can be explained in a high percentage by correlating them with the hemodynamic findings at rest and exercise, which are indirect parameters of velocity profiles. Hemolysis is higher after aortic than after mitral valve replacement, with the exception of St. Jude valves. In patients with perivalvular leakage or valve thrombosis, red cell damage is more pronounced than in normally functioning prostheses (p less than 0.0005). When the hemolysis characteristics of the individual types of prosthesis are taken into account, the degree of hemolysis is a reliable indicator (p less than 0.05) of the functional integrity of the prosthesis. However, the degree of hemolysis does not correlate with the hemodynamic significance of perivalvular regurgitation.
Syntheitic studies on sulfone biotin derivatives. II. A novel synthesis of cis-3,4-ureylene-thiophane-1,1-dioxide. (1974)

A novel synthesis of cis-3, 4-ureylenethiophane-1, 1-dioxide (VII) via a key intermediate which can be obtained by only two steps from sulfolene was described.
The Practice of Flash Point Determination: A Laboratory Resource (2013)

Description Satisfy: Flash point defines petroleum product quality. This user's guide compares commonly used flash point apparatus and procedures and provides general guidance in the use and interpretation of standard ASTM flash point methods, including: Chapters cover: The manual is intended for those who run the flash point tests or for the users of the results of such tests. This includes lab technicians in testing laboratories, trucking, railway, aviation, shipping and warehousing of volatile materials to determine if they get what they ordered based on the flash point and the volatility of the materials. Also for businesses that receive DOT/EPA regulated petroleum products and refinery labs.
Quality Assurance for a Measurement Program (1984)

Measurement data of adequate quality are necessary if environmental problems are to be properly understood and effective actions taken to correct them. Quality assurance programs for all aspects of the measurement process are necessary to provide such data. In previous papers, the general aspects of quality assurance of measurements (1,2) and the essential features of a laboratory quality assurance program (3) have been presented. This paper discusses the general features of quality assurance for measurement programs, and especially monitoring programs. In a classical paper, Deming presented fourteen points for management of quality and productivity (4). Three of these points are particularly relevant for monitoring programs and may be paraphrased as follows: ○ The new philosophy: we can no longer accept defects. ○ Depend on vendors of services that use process control. ○ Price has no meaning without evidence of quality. Demand statistical control by vendors with supporting evidence. Monitoring programs
ARTIFICIAL NEURAL NETWORK MODEL FOR ACCURATE PREDICTION OF PRESSURE DROP IN HORIZONTAL AND NEAR-HORIZONTAL-MULTIPHASE FLOW (2002)

ABSTRACT Accurate prediction of pressure drop for multiphase flow in horizontal and near horizontal pipes is needed for effective design of flow lines and piping networks. The increased application of horizontal wells further signified the need for accurate prediction of pressure drop. Several correlations and mechanistic models have been developed since 1950. In addition to the limitations on the applicability of all existing correlations, they all fails to provide the desired accuracy of pressure drop predictions. The recently developed mechanistic models provided some improvements in pressure drop prediction over the empirical correlations. However, there is still a need to further improve the accuracy of prediction for a more effective and economical design of wells and surface piping networks. This paper presents an Artificial Neural Network (ANN) model for prediction of pressure drop in horizontal and near-horizontal multiphase flow. The model was developed and tested using field data covering a wide range of variables. A total of 225 field data sets were used for training- and 113 sets data for cross-validation of the model. Another 112 sets of data were used to test the prediction accuracy of the model and compare its performance against existing correlations and mechanistic models. The results showed that the present model significantly outperforms all other methods and provides predictions with accuracy that has never been possible. A trend analysis was also conducted and showed that the present model provides the expected effects of the various physical parameters on pressure drop.
Design of a self-testing and self-repairing structure for highly hierarchical ultra-large capacity memory chips (1993)

A memory architecture with the capability of self-testing and self-repairing is presented. The contributions of this memory architecture are twofold. First, because it incorporates self-testing and self-repairing structures, the memory chip can perform tests, locate faults, and repair itself without any external assistance from either test engineers or test equipment. This will greatly improve the functional yield and reduce the production cost. Second, the hierarchical organization used to achieve optimal conditions for memory access time also helps increase the efficiency of the self-testing and self-repairing structures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Robust mesh-based hashing for copy detection and tracing of images (2005)

Due to the desired non-invasive property, non-data hiding (called media hashing here) is considered to be an alternative to achieve many applications previously accomplished with watermarking. Recently, media hashing techniques for content identification have been gradually emerging. However, none of them are really resistant against geometrical attacks. In this paper, our aim is to propose a geometry-invariant image hashing scheme, which can be employed for content copy detection and tracing. Our system is mainly composed of three components: (i) robust mesh extraction; (iii) mesh-based robust hash extraction; and (iii) hash matching for similarity measurement. Exhaustive experimental results obtained from benchmark attacks have confirmed the performance of the proposed method.
Cytotoxic thresholds of vincristine in a murine and a human leukemia cell line in vitro. (1979)

L1210 murine leukemia and CEM human lymphoblastoid leukemia cells were exposed to vincristine sulfate in vitro. The response of these cell lines to this agent was measured by the colony-forming ability of L1210 cells in soft agar and inhibition of growth of CEM in suspension culture. Incremental increases of vincristine concentrations in excess of 2 x 10(-9) M produced a progressive reduction of survival of L1210 cells and suppression of CEM growth under the condition of constant drug exposure. A maximum cytotoxic effect was reached with drug concentrations between 10(-8) and 10(-7) M. When L1210 cells were exposed to vincristine for a variable length of time ranging from 0.5 to 24 hr, 10(-7) M produced a noticeable cytotoxic effect following an incubation of only 30 min. A 50% cell kill of L1210 cells and a 50% reduction of CEM cell growth were produced by 10(-7) M following a 1- to 3-hr period of exposure; 6 to 12 hr were required to produce a similar effect at a vincristine concentration of 10(-8) M. Therefore, the antitumor effect of vincristine is critically dependent on both concentration and duration of exposure. These data suggest the possibility that the effectiveness of vincristine as an antitumor agent could be enhanced if methods are developed to prolong exposure of neoplastic tissues for longer periods of time than currently produced by conventional methods of administration.
High switching speed and coloration efficiency of titanium-doped vanadium oxide thin film electrochromic devices (2013)

Titanium (Ti)-doped vanadium oxide thin films were fabricated by electrochemical deposition on linear polyethylenimine (LPEI)-modified indium tin oxide-coated glass from mixed vanadium oxide and titanium oxide solutions with different Ti concentrations. The as-prepared films were investigated by X-ray diffraction (XRD), atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). The electrochemical behaviour of the films was studied using cyclic voltammetry (CV) in 1.0 M LiClO4/propylene carbonate solution. Electrochromism of the oxide films upon Li-ion intercalation/deintercalation was investigated by transmittance measurements during the CV process. The charge transfer resistance of the Ti-doped vanadium oxide film was systematically analyzed with electrochemical impedance spectroscopy (EIS). The amorphous Ti-doped vanadium oxide film containing 4 mol% Ti exhibited the highest transmittance contrast (Δ%T = Tmax − Tmin) of ca. 51.1%T, and coloration efficiency of 95.7 cm2 C−1 at 415 nm. By increasing the Ti content to 10 mol%, the Ti-doped vanadium oxide film exhibited high switching speed and good cycling reversibility reaching 80% of colouring and bleaching time of 5 and 6 s, respectively. Furthermore, the transmittance contrast drops by only 10% after 600 cycles in a two-electrode system.
Cloning and Characterization of<i>vuuA</i>, a Gene Encoding the<i>Vibrio vulnificus</i>Ferric Vulnibactin Receptor (2000)

The ability of Vibrio vulnificus to acquire iron from the host has been shown to correlate with virulence. Many iron transport genes are regulated by iron, and in V. vulnificus, transcriptional regulation by iron depends on the fur gene. The N-terminal amino acid sequence of a 72-kDa iron-regulated outer membrane protein purified from a V. vulnificus fur mutant had 53% homology with the first 15 amino acids of the mature protein of the Vibrio cholerae vibriobactin receptor, ViuA. In this report, we describe the cloning, DNA sequence, mutagenesis, and analysis of transcriptional regulation of the structural gene for VuuA, the vulnibactin receptor of V. vulnificus. Analysis of the DNA sequence of the vuuA promoter region demonstrated a sequence identical to the upstream Fur box of V. cholerae viuA. Northern blot analysis showed that the transcript was strongly regulated by iron. The amino acid sequence of VuuA was 74% identical to the sequence of V. cholerae ViuA and was homologous to those of several TonB-dependent outer membrane receptors. An internal deletion of the V. vulnificus vuuA gene resulted in the loss of expression of the 72-kDa protein and the loss of the ability to use transferrin or vulnibactin as a source of iron. This mutant showed reduced virulence in an infant mouse model. Introduction of a plasmid containing the complete viuA coding sequence and 342 bp of upstream DNA into the mutant restored ferric vulnibactin and ferric transferrin utilization to the mutant.
Web-R: a tool to record & replay personal web navigation (2003)

This poster presents a useful tool to capture the content of browsing sessions. Web-R saves systematically all the components sufficient and necessary to visualize offline the page, the same way it was displayed online. In order to avoid the saturation of local disk, Web-R integrates a page comparison mechanism to avoid unnecessary redundancy and, in addition, provides a way to manage the maximum storage space. We give some insights than, in typical cases, this storage is compatible with today's casual hard disk capacities and costs, along years. Moreover, since the full content of visited pages is stored, the Web-R user can access and process (e.g. sort, extract) several information including path and visit statistics, therefore giving him/her a global view on his/her personal navigation.
A single stage three level resonant PFC AC/DC converter using combined phase-shift and frequency control (2005)

This paper presents a new single stage three level resonant power factor correction AC/DC converter suitable for high power applications (in the order of kilowatts) with a universal input voltage range (90-265 Vrms). The proposed topology integrates a boost input current shaper with a half-bridge three-level LCC resonant DC/DC converter. The converter operation is controlled by means of a combination of phase-shift and frequency control. The phase-shift between the switch gate pulses is used to regulate the DC-bus voltage to a specified level for all loading conditions, whereas, frequency control is used to tightly regulate the output voltage. An auxiliary circuit is used in order to balance the voltage across the two DC-bus capacitors. The input inductor operates in discontinuous conduction mode. The effectiveness of the proposed converter is verified for a 2.3 kW, 500 kHz converter with an input voltage range of (90-265 Vrms) and a DC output voltage of 48 V.
Tau Proteins and Neurofibrillary Degeneration (1991)

The paired helical filament is the major fibrous component of neurofibrillary pathology in Alzheimer's disease. Over the last three years evidence has accumulated that the microtubule-associated protein tau forms an important, if not the sole, constituent of the paired helical filament. Tau protein in normal brain is bound to axonal microtubules by a tandem repeat region. In Alzheimer's disease a proportion of tau protein becomes abnormally phosphorylated and is no longer associated with axonal microtubules but instead accumulates in paired helical filaments throughout affected nerve cells. The tandem repeat region contributes substantially to the structural core of the paired helical filament, around which the amino-terminal half of the molecule forms a disordered coat.
Complexation and reduction-oxidation equilibriums of titanium chlorides in gaseous aluminum chloride (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplexation and reduction-oxidation equilibriums of titanium chlorides in gaseous aluminum chlorideMorten Soerlie and Harald A. OeyeCite this: Inorg. Chem. 1978, 17, 9, 2473–2484Publication Date (Print):September 1, 1978Publication History Published online1 May 2002Published inissue 1 September 1978https://pubs.acs.org/doi/10.1021/ic50187a028https://doi.org/10.1021/ic50187a028research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
c-<i>myc</i> Is Required for Osteoclast Differentiation (2002)

The role of the receptor activator of nuclear factor kappaB (NF-kappaB) ligand (RANKL)-a tumor necrosis factor (TNF)-related cytokine-in osteoclast formation has been established clearly. However, the downstream signaling pathways activated by this cytokine remain largely unknown. To identify genes that play a role in osteoclastogenesis, we used RAW 264.7 mouse monocytes as a model system for the differentiation of multinucleated osteoclasts from mononucleated precursors. RAW 264.7 cells were induced with RANKL to form multinucleated giant osteoclast-like cells (OCLs) that expressed a number of osteoclast-specific markers and were able to form resorption pits on both calcium phosphate films and bone slices. This system was used to identify genes that are regulated by RANKL and may play a role in osteoclast differentiation. The proto-oncogene c-myc was strongly up-regulated in RANKL-induced OCLs but was absent in undifferentiated cells. Expression of Myc partners Max and Mad, on the other hand, was constant during OCL differentiation. We expressed a dominant negative Myc in RAW 264.7 cells and were able to block RANKL-induced OCL formation. Northern Blot analysis revealed a delay and a significant reduction in the level of messenger RNA (mRNA) for tartrate-resistant acid phosphatase (TRAP) and cathepsin K. We conclude that c-myc is a downstream target of RANKL and its expression is required for RANKL-induced osteoclastogenesis.
Reactions of Nonsuscepts to Fungal Pathogens (1980)

Beneficial microbes in the microbiome of plant roots improve plant health. Induced systemic resistance (ISR) emerged as an important mechanism by which selected plant growth–promoting bacteria and fungi in the rhizosphere prime the whole plant body for ...Read More
Parametric amplification in presence of dispersion fluctuations (2004)

Parametric amplification in fibers with dispersion fluctuations is analyzed. The fluctuations are modelled as a stochastic process, with their size at a given position modelled as a Gaussian, and the autocorrelation decreasing exponentially. Two models are studied: in one the dispersion is piecewise constant, while in the other it is continuous. We find that the amplification does not depend on the models' details and that only fluctuations with long correlation lengths affect the amplification significantly.
A mechanistic investigation of the photoinduced, copper-mediated cross-coupling of an aryl thiol with an aryl halide (2016)

Photoinduced, copper-catalyzed cross-coupling can offer a complementary approach to thermal (non-photoinduced) methods for generating C-X (X = C, N, O, S, etc.) bonds. In this report, we describe the first detailed mechanistic investigation of one of the processes that we have developed, specifically, the (stoichiometric) coupling of a copper-thiolate with an aryl iodide. In particular, we focus on the chemistry of a discrete [Cu<sup>I</sup>(SAr)<sub>2</sub>]<sup>-</sup> complex (Ar = 2,6-dimethylphenyl), applying a range of techniques, including ESI-MS, cyclic voltammetry, transient luminescence spectroscopy, optical spectroscopy, DFT calculations, Stern-Volmer analysis, EPR spectroscopy, actinometry, and reactivity studies. The available data are consistent with the viability of a pathway in which photoexcited [Cu<sup>I</sup>(SAr)<sub>2</sub>]<sup>-</sup>* serves as an electron donor to an aryl iodide to afford an aryl radical, which then reacts in cage with the newly generated copper(II)-thiolate to furnish the cross-coupling product in a non-chain process.
Bioactive Components and Possible Activities of Medicinal Mushrooms in Alleviating the Pathogenesis of Nonalcoholic Fatty Liver Disease (Review) (2021)

Nonalcoholic fatty liver disease (NAFLD) is a global disease that is closely associated with obesity, type 2 diabetes mellitus, and cardiovascular disease. Excessive fat accumulation, fatty degeneration, and chronic inflammation of the liver activate the progression of NAFLD from simple steatosis to nonalcoholic steatohepatitis and further to liver fibrosis, cirrhosis, and hepatocellular carcinoma. The underlying mechanism for the development and progression of NAFLD is complex and a multiple-hit hypothesis including dietary, environmental, genetic, and epigenetic factors has been raised. Increased de novo lipogenesis, decreased lipolysis, and insulin resistance are associated with the development of NAFLD. Currently, no effective drug therapies are approved for the treatment of NAFLD. Several medicinal mushrooms have been found to have significant weight control and gut microbe modulation activities and antihypertriglyceridemic, antihyperglycemic, antioxidant, and anti-inflammatory effects, which may be useful to prevent and attenuate the development and progression of NAFLD. These beneficial effects are associated with mushrooms' bioactive components, such as polysaccharides, dietary fibers, antioxidants, and other compounds derived from fruiting bodies, cultured mycelium, and/or broth of medicinal mushrooms. This article presents an overview of multiple aspects of NAFLD, including the epidemiology, pathogenesis, management, and treatment. The bioactive components and possible activities of medicinal mushrooms in alleviating the pathogenesis of NAFLD are also reviewed.
Metastatic Chondrosarcoma in a Corn Snake (Pantherophis guttatus) (2012)

Abstract An approximately two-year-old corn snake ( Pantherophis guttatus ) presented with a swelling of the mandible. The animal was treated for two months with no response. Unfortunately, the snake's condition deteriorated and it was euthanized. Grossly, the mass in the mandible was yellow–white and replaced normal bone and soft tissue of the jaw. Additional masses were noted in the heart, kidney, lung, pancreas, and eye. The mass in the mandible was comprised of a sheet of amorphous basophilic material resembling typical cartilage matrix with slightly irregular lacunar spaces. Tumor cells had abundant cytoplasm, vesicular or hyperchromatic nuclei, and prominent nucleoli. Mitotic figures were not seen. Scattered foci of neoplastic cartilaginous cells were noted in the heart, lung, kidney, pancreas, and eye. The final diagnosis for this case was secondary chondrosarcoma. Chondrosarcomas are not considered a common form of neoplasia in reptiles. When it is diagnosed, it appears to be more commonly associated with the vertebral column. Chondrosarcomas should be considered in the differential list for snakes (or other reptiles) that present with masses associated with the bone or cartilage.
Immunobiology of Lipopolysaccharide (LPS) and LPS‐Derived Immunoconjugates Vaccinate Mice against <i>Salmonella typhimurium</i> (1998)

The immunobiology of lipopolysaccharide (LPS) of Salmonella typhimurium LT2-71 was studied in its native, modified and conjugated states using mice as the experimental model. An alkali-treated detoxified fraction of LPS (D-LPS) was found to be not only non-toxic but also equally immunogenic, like LPS. In addition D-LPS alone or conjugated with enterotoxin or hemolysin was also non-pyrogenic and non-indurogenic. The immunoprophylactic activity of D-LPS conjugates to a 100 ID50 challenge dose of S. typhimurium was also higher than that of detoxified LPS or native LPS.