gebhart/patrepeval huggingface dataset:
Adaptive Robotic Deburring of Die-Cast Parts with Position and Orientation Measurements Using a 3D Laser-Triangulation Sensor (2016)

A system for adaptive robotic deburring with a correction of the errors in workpiece positioning is presented. The correction is based on 3D measurements of the workpiece's surface and its registration to the target surface, measured on a reference workpiece. The surface measurement is performed with a laser-triangulation profilometer. The reference tool path is determined using robot teaching on the reference, already deburred, workpiece. The positioning errors of the currently processed workpiece are compensated by tool path adaptation in accordance with the registration results by means of rotation and translation. The experiments showed that the average precision of localization is 0.06 mm and the average bias between the true and measured values is 0.23 mm. The developed adaptive system is also applicable in other similar applications where it is difficult to ensure repeatable clamping of the workpiece.
Ion implanted InSb photodetectors (1977)

Planar n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> p- and p <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> n-photodetectors have been made in InSb by implantation of sulfur and beryllium, n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> p-detectors show a flat response from 4.5 to 5.3 µm, resulting from the Burstein-Moss effect, whereas the p <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> n-detectors show the usual behavior of the response with a shift in the cutoff-wavelength from 4.8 to 5.5 µm depending on the substrate doping. The obtained peak detectivities are 3 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> cmHz <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sup> W <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> for sulfur implanted and 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> cmHz <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sup> W <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> for beryllium implanted diodes at a field of view of 0°. The corresponding externalquantum efficiencies are 40 to 60% for all detectors.
An efficient and scalable architecture for neural networks with backpropagation learning (2005)

This paper describes the implementation, in reconfigurable hardware, of an artificial neural network (ANN) system architecture which features online supervised learning capabilities and resource virtualization. Neural networks are artificial systems inspired by the brain's cognitive behavior, which can learn tasks with some degree of complexity, such as, optimization problems, data mining and text and speech recognition. The architecture proposed takes advantage of distinct datapaths for the forward and backward propagation stages to significantly improve the performance of the learning phase. The architecture is easily scalable and able to cope with several network sizes with the same hardware. Networks larger than the available resources are handled by hardware virtualization. The results show that the proposed architecture leads to speed ups of one order of magnitude comparing to high-end software solutions.
The power relay satellite (1994)

The availability and use of renewable energy sources compatible with reducing risks to the global environment are key to sustainable development. Large-scale, renewable energy resources at undeveloped or underutilized sites are potentially available on several continents. The Power Relay Satellite (PRS) concept has the potential to access these remote energy resources by coupling primary electricity generation from terrestrial transmission lines. A global PRS network can be envisioned to provide a high degree of flexibility for supplying energy demands worldwide with wireless power transmitted from sites on Earth to geosynchronous orbit and then reflected to receivers interfacing with terrestrial power transmision networks. Past developments in wireless power transmission (WPT) are reviewed and recent successful results are noted. The origins of the PRS concept, and a possible configuration are discussed, principles of WPT at microwave frequencies, functional requirements, and system design contraints are outlined, and space transportation concepts presented. PRS assessments including applicable technologies, economic projections, and societal issues are highlighted. It is concluded that the PRS provides a promising option to access renewable resources at great distances from major markets, and represents an important stage in the future development in the future of solar power satellites.
TnphoA-mediated disruption of K54 capsular polysaccharide genes in Escherichia coli confers serum sensitivity (1993)

To assess whether non-K1, group 2 capsular serotypes are important in conferring serum resistance to extraintestinal isolates of Escherichia coli, a K54 blood isolate (CP9) was evaluated as a model pathogen. Transposon mutagenesis (TnphoA) was used to generate isogenic capsule-negative mutants. CP9 was resistant to the bactericidal effects of serum, growing in 80% serum. In contrast, all of the capsule-negative mutants had an increased sensitivity to 80% normal human serum, undergoing a 2- to 3-log kill over 3 h when starting inocula of 10(4) to 10(7) CFU/ml were used. The killing of the capsule-negative strains was mediated through the alternative complement pathway and not by lysozyme or beta-lysins. The protective effect of the K54 capsule against the bactericidal activity of serum was not through inhibition of the complement cascade, nor did it appear to be through a difference in the binding of C3.
Rapid Mechanotransduction in Situ at the Luminal Cell Surface of Vascular Endothelium and Its Caveolae (1998)

The vascular endothelium is uniquely positioned between the blood and tissue compartments to receive directly the fluid forces generated by the blood flowing through the vasculature. These forces invoke specific responses within endothelial cells and serve to modulate their intrinsic structure and function. The mechanisms by which hemodynamic forces are detected and converted by endothelia into a sequence of biological and even pathological responses are presently unknown. By purifying and subfractionating the luminal endothelial cell plasma membrane from tissue, we show, for the first time, that not only does mechanotransduction occur at the endothelial cell surface directly exposed to vascular flow in vivo but also increased flow in situ induces rapid tyrosine phosphorylation of luminal endothelial cell surface proteins located primarily in the plasmalemmal invaginations called caveolae. Increased flow induces the translocation of signaling molecules primarily to caveolae, ultimately activating the Ras-Raf-mitogen-activated protein kinase pathway. This signaling appears to require intact caveolae. Filipin-induced disassembly of caveolae inhibits both proximal signaling events at the cell surface and downstream activation of the mitogen-activated protein kinase pathway. With the molecular machinery required for mediating rapid flow-induced responses as seen in endothelium, caveolae may be flow-sensing organelles converting mechanical stimuli into chemical signals transmitted into the cell.
Irreversible enzyme inhibitors. 181. Inhibition of brain choline acetyltransferase by derivatives of 4-stilbazole (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIrreversible enzyme inhibitors. 181. Inhibition of brain choline acetyltransferase by derivatives of 4-stilbazoleBernard Randall Baker and Raymond E. GibsonCite this: J. Med. Chem. 1971, 14, 4, 315–322Publication Date (Print):April 1, 1971Publication History Published online1 May 2002Published inissue 1 April 1971https://pubs.acs.org/doi/10.1021/jm00286a011https://doi.org/10.1021/jm00286a011research-articleACS PublicationsRequest reuse permissionsArticle Views241Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Anti-cancer vaccines - a one-hit wonder? (2014)

Immunization against common bacterial and viral diseases has helped prevent millions of deaths worldwide. More recently, the concept of vaccination has been developed into a potentially novel strategy to treat and prevent cancer formation, progression, and spread. Over the past few years, a handful of anti-cancer vaccines have been licensed and approved for use in clinical practice, thus providing a breakthrough in the field. However, the path has not always been easy, with many hurdles that have had to be overcome in order to reach this point. Nevertheless, with more anti-cancer vaccines currently in development, there is still hope that they can eventually become routine tools used in the treatment and prevention of cancer in the future. This review will discuss in detail both types of anti-cancer vaccine presently used in clinical practice - therapeutic and preventive - before considering some of the more promising anti-cancer vaccines that are currently in development. Finally, the issue of side effects and the debate surrounding the overall cost-effectiveness of anti-cancer vaccines will be examined.
Automated production of [<sup>68</sup>Ga]Ga‐DOTANOC and [<sup>68</sup>Ga]Ga‐PSMA‐11 using a TRACERlab FX<sub>FN</sub> synthesis module (2019)

The interest in gallium-68 labelled positron-emission tomography probes continues to increase around the world. However, one of the barriers for routine clinical use is the cost of the automated synthesis units for relatively simple labelling procedures. Herein, we describe the adaptation of a TRACERlab FX<sub>FN</sub> synthesis module for the automated production of gallium-68 radiopharmaceuticals using a cation-exchange cartridge for postprocessing of the <sup>68</sup> Ge/<sup>68</sup> Ga generator eluate. The recovery of activity from the cartridge was 95.6% to 98.9% using solutions of acidified sodium chloride (5 M with pH = 1-3). The radiosyntheses of [<sup>68</sup> Ga]Ga-DOTANOC and [<sup>68</sup> Ga]Ga-PSMA-11 were performed using acetate sodium buffer or 4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid, with a total duration of 21 and 23 minutes, respectively, including generator elution and radiopharmaceutical dispensing. Activity yields were 77% ± 2% for [<sup>68</sup> Ga]Ga-PSMA-11 and 68% ± 3% for [<sup>68</sup> Ga]Ga-DOTANOC (n > 100). The labelled peptides had a radiochemical purity exceeding 97%, and all quality control parameters were in conformity with the limits prescribed by the European Pharmacopoeia.
Gene Cloning of Cellobiohydrolase II from the White Rot Fungus<i>Irpex lacteus</i>MC-2 and Its Expression in<i>Pichia pastoris</i> (2008)

A gene (cel4) coding for a cellobiohydrolase II (Ex-4) was isolated from the white rot basidiomycete, Irpex lacteus strain MC-2. The cel4 ORF was composed of 452 amino acid residues and was interrupted by eight introns. Its deduced amino acid sequence revealed a multi domain structure composed of a cellulose-binding domain, a linker, and a catalytic domain belonging to family 6 of glycosyl hydrolases, from the N-terminus. cel4 cDNA was successfully expressed in the yeast Pichia pastoris. Recombinant Ex-4 showed endo-processive degrading activity towards cellulosic substrates, and a synergistic effect in the degradation of Avicel was observed when the enzyme acted together with either cellobiohydrolase I (Ex-1) or endoglucanase (En-1) produced by I. lacteus MC-2.
Reactions of muconaldehyde isomers with nucleophiles including tri-O-acetylguanosine: Formation of 1,2-disubstituted pyrroles from reactions of the (Z,Z)-isomer with primary amines (1993)

(Z,Z)-Muconaldehyde reacts with primary amines, including valine and lysine (epsilon-amino), to afford N-substituted-2-(oxoethyl)pyrroles, which were reduced with sodium borohydride to the more stable N-substituted-2-(hydroxyethyl)pyrroles. The formation of the pyrrole aldehydes was performed in a variety of solvents including aqueous methanol. With tri-O-acetylguanosine, the putative pyrrole aldehyde derived from reaction at NH2 condenses with N-1 (guanine component) to afford a bicyclic adduct: 4,5-dihydro-5-hydroxy-10-beta-D-tri-O- acetylribosylpyrrolo[1',2':3,4]pyrimido[1,2-a]purin-7(10H)-one (5a). This was hydrolyzed to 4,5-dihydro-5-hydroxy-10-beta-D- ribosylpyrrolo[1',2':3,4]pyrimido[1,2-a]purin-7(10H)-one (5b). The structures of 5a and 5b were primarily based on NMR evidence and comparison with 4,5-dihydro-5-hydroxy-9-methylpyrrolo[1',2':3,4]pyrimido[2,1-b] pyrimidin-7-one (7), obtained from reacting (Z,Z)-muconaldehyde with 2-amino-4-hydroxy-6-methylpyrimidine. (E,Z)-Muconaldehyde also reacted with primary amines to give N-substituted-2-(oxoethyl)pyrroles, whereas (E,E)-muconaldehyde gave bis-imines. The results described are discussed in the context of the carcinogenicity of benzene.
The Man Who Sold Louisiana: The Career of Francois Barbe-Marbois (1942)

The Man Who Sold Louisiana: The Career of Francois Barbé-Marbois. By E. Wilson Lyon. (Norman: University of Oklahoma Press, 1942. xix + 240 pp. Illustrations, maps, and bibliographical note. $2.75.) Get access Laura A. White Laura A. White The University of Wyoming Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 29, Issue 3, December 1942, Page 433, https://doi.org/10.2307/1897939 Published: 01 December 1942
Rabbit: A Compiler for Scheme (1978)

We have developed a compiler for the lexically-scoped dialect of LISP known as SCHEME. The compiler knows relatively little about specific data manipulation primitives such as arithmetic operators, but concentrates on general issues of environment and control. Rather than having specialized knowledge about a large variety of control and environment constructs, the compiler handles only a small basis set which reflects the semantics of lambda-calculus. All of the traditional imperative constructs, such as sequencing, assignment, looping, GOTO, as well as many standard LISP constructs such as AND, OR, and COND, are expressed in macros in terms of the applicative basis set. A small number of optimization techniques, coupled with the treatment of function calls as GOTO statements, serve to produce code as good as that produced by more traditional compilers. The macro approach enables speedy implementation of new constructs as desired without sacrificing efficiency in the generated code. A fair amount of analysis is devoted to determining whether environments may be stack-allocated or must be heap-allocated. Heap-allocated environments are necessary in general because SCHEME (unlike Algol 60 and Algol 68, for example) allows procedures with free lexically scoped variables to be returned as the values of other procedures; the Algol stack-allocation environment strategy does not suffice. The methods used here indicate that a heap-allocating generalization of the "display" technique leads to an efficient implementation of such "upward funargs". Moreover, compile-time optimization and analysis can eliminate many "funargs" entirely, and so far fewer environment structures need be allocated at run time than might be expected. A subset of SCHEME (rather than triples, for example) serves as the representation intermediate between the optimized SCHEME code and the final output code; code is expressed in this subset in the so-called continuation-passing style. As a subset of SCHEME, it enjoys the same theoretical properties; one could even apply the same optimizer used on the input code to the intermediate code. However, the subset is so chosen that all temporary quantities are made manifest as variables, and no control stack is needed to evaluate it. As a result, this apparently applicative representation admits an imperative interpretation which permits easy transcription to final imperative machine code. These qualities suggest that an applicative language like SCHEME is a better candidate for an UNCOL than the more imperative candidates proposed to date.
High-quality epitaxial growth of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>γ</mml:mi></mml:math>-alumina films on<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>α</mml:mi></mml:math>-alumina sapphire induced by ion-beam bombardment (1995)

We report the formation of epitaxial $\ensuremath{\gamma}$-alumina thin films on $\ensuremath{\alpha}$-alumina substrates induced by ion-beam bombardment. Single-crystal (0001) $\ensuremath{\alpha}$-alumina was coated with 70-nm amorphous-alumina thin films and then bombarded with either 360-keV argon ions or 180-keV oxygen ions at 400, 500, and 600 \ifmmode^\circ\else\textdegree\fi{}C. Ion-channeling measurements showed a consistent minimum yield of 50% for the aluminum in the grown films. Crosssectional transmission-electron microscopy revealed the formation of $\ensuremath{\gamma}$-alumina epitaxially grown onto $\ensuremath{\alpha}$-alumina with an orientation relationship $[1\overline{1}0](111)\ensuremath{\gamma}\ensuremath{\parallel}[01\overline{1}0](0001)\ensuremath{\alpha}$. The epitaxy of $\ensuremath{\gamma}$-alumina was further confirmed by x-ray-diffraction $\ensuremath{\varphi}$ scans. This study indicates that ion-beam bombardment at 400-600 \ifmmode^\circ\else\textdegree\fi{}C not only induces the amorphous-to-$\ensuremath{\gamma}$ phase transformation but also effectively eliminates {111} twins of $\ensuremath{\gamma}$-alumina, which are normally observed after thermal annealing at 800-900 \ifmmode^\circ\else\textdegree\fi{}C.
Fiber Optic Particle Concentration Sensor (1986)

A particle concentration sensor would be useful in many industrial process monitoring applications where in situ measurements are required. These applications include determination of butterfat content of milk, percent insolubles in engine oil, and cell concentration in a bioreactor. A fiber optic probe was designed to measure particle concentration by monitoring the scattered light from the particle-light interaction at the end of a fiber-optic-based probe tip. Linear output was obtained from the sensor over a large range of particle loading for a suspension of 1.7 μm polystyrene microspheres in water and E. coli bacteria in a fermenter.
A design of experiments approach to an optimized SC-1/megasonic clean for sub-0.15 micron particle removal (1993)

A statistical design of experiments approach has been employed to evaluate the particle removal efficacy of the SC-1/megasonic clean for sub-0.15 {mu}m inorganic particles. The effects of megasonic input power, solution chemistry, bath temperature, and immersion time have been investigated. Immersion time was not observed to be a statistically significant factor. The NH{sub 4}OH/H{sub 2}O{sub 2} ratio was significant, but varying the molar H{sub 2}0{sub 2} concentration had no effect on inorganic particle removal. Substantially diluted chemistries, performed with high megasonic input power and moderate-to-elevated temperatures, was shown to be very effective for small particle removal.
Use of Ribavirin for Hepatitis C Treatment in the Modern Direct-acting Antiviral Era (2018)

Ribavirin, once a staple of hepatitis C treatment, has significant drawbacks, including treatment-limiting side effects, the requirement for intensive laboratory monitoring, the need for frequent dose adjustments, and teratogenicity. These factors make it difficult to escalate ribavirin-based HCV treatment to most infected patients globally. Most studies have shown comparable response rates between ribavirin-inclusive and ribavirin-sparing regimens in uncomplicated patient populations. However, ribavirin is still used in the management of patients who have failed previous therapy as well as those with decompensated liver disease. In this review, we explore the evidence supporting the use of ribavirin in the current climate of hepatitis C treatment with oral combination direct-acting antiviral agents.
Structure Determination of a New Spirobicyclic Triterpenoid from <i>Iris foetidissima</i> (1990)

Abstract The novel iridal 10 has been isolated from rhizome extracts of Iris foetidissima. Its structure was established by spectroscopic methods and oxidative degradation. Final proof of the spirobicyclic nature of the compound – a new feature in the triterpenoid field – was afforded by the correlations observed in the 2D‐HMBC‐ ( 1 H‐detected multiple‐bond heteronuclear multiple‐quantum coherence) spectrum. The possible biogenesis of this unusual compound is discussed.
“Unattached” Fraction of Short-lived Rn Decay Products in Indoor and Outdoor Environments (1990)

The unattached fraction fp of potential alpha energy of short-lived Rn decay products was measured under realistic, natural conditions in different dwellings and in the open atmosphere by a single-screen technique. An improved data evaluation method was developed where the measured activities of 218Po (RaA) and 214Pb (RaB) were corrected by the screen-attached activities of 214Bi (214Po) [RaC (RaC')]. This method is based on the experimental observation that the 214Bi (214Po) unattached activities are negligible under realistic living conditions and that the size distributions of the aerosol-attached activities of all short-lived Rn daughters are identical. In closed rooms without additional aerosol sources, a mean unattached fraction fp of the potential alpha energy of 0.096 was obtained at a mean aerosol particle concentration of 6100 cm-3 and at a mean equilibrium factor F of 0.30. This mean fp value is about three times higher than the value used in the literature for the radiation exposure calculation of the human public. In closed rooms with additional aerosol sources (cigarette smoke, heating systems, aerosols from a burning candle), the aerosol particle concentrations ranged up to 10(6) cm-3 and the attachment rates, X, increased up to 1000 h-1. The fp values sometimes decreased below the detection limit of 0.005, and the F values increased to as high as 0.77. In the ambient atmosphere in the vicinity of Göttingen, a mean unattached fraction fp of 0.02 and a mean aerosol particle concentration of 3.4 x 10(4) cm-3 were measured at 1 m above the ground. The mean equilibrium factor F was determined to be 0.7.