gebhart/patrepeval huggingface dataset:
Humoral Pattern Recognition and the Complement System (2013)

In the context of immunity, pattern recognition is the art of discriminating friend from foe and innocuous from noxious. The basis of discrimination is the existence of evolutionarily conserved patterns on microorganisms, which are intrinsic to these microorganisms and necessary for their function and existence. Such immutable or slowly evolving patterns are ideal handles for recognition and have been targeted by early cellular immune defence mechanisms such as Toll-like receptors, NOD-like receptors, RIG-I-like receptors, C-type lectin receptors and by humoral defence mechanisms such as the complement system. Complement is a proteolytic cascade system comprising around 35 different soluble and membrane-bound proteins. It constitutes a central part of the innate immune system, mediating several major innate effector functions and modulating adaptive immune responses. The complement cascade proceeds via controlled, limited proteolysis and conformational changes of constituent proteins through three activation pathways: the classical pathway, the alternative pathway and the lectin pathway, which converge in common effector functions. Here, we review the nature of the pattern recognition molecules involved in complement activation, as well as their close relatives with no or unknown capacity for activating complement. We proceed to examine the composition of the pattern recognition complexes involved in complement activation, focusing on those of the lectin pathway, and arrive at a new model for their mechanism of operation, supported by recently emerging evidence.
Adverse Events Associated With Concurrent Chemoradiation Therapy in Patients With Head and Neck Cancer (2009)

Patients receiving CRT experience a substantial number of treatment-related adverse events, primarily affecting oropharyngeal and laryngeal function, with improvement noted for the current IMRT protocol. Improving dental prosthetic rehabilitation and including evaluations with speech and swallowing pathologists before and during treatment may enhance patient outcomes.
[Experience of pediatric application of bifidumbacterin multi, a biologically active food supplement]. (2005)

The article is dedicated to a clinical trial of Bifidumbacterin Multi-1, a biologically active food supplement (BAFS) for children aged 0 to 3 years. The study showed that application of BAFS in children with intestinal dysbiosis helped to cope with the symptoms of alimentary disturbances, promoted improvement of body mass index, increase of hemoglobin end erythrocyte level, suppression of zymotic and putrefactive dyspepsia, decrease of inflammation of the intestinal mucosa, elimination of bibidobacterial deficit, and reduction of conditionally pathogenic microflora. Bifidumbacterin Multi-1 was well tolerated and highly effective according to clinical and laboratory data. This preparation may be recommended as a component of complex therapy in children aged 0 to 3 years old.
Self-Associative Behavior and Drug-Solubilizing Ability of Poloxamine (Tetronic) Block Copolymers (2008)

The incidence of the structural features on the self-assembly of different poloxamines (the conventional sequential Tetronic 304, 901, 904, 908, 1107, 1301, and 1307; a reverse-sequential counterpart Tetronic 150R1; and a chemically modified derivative, N-methylated Tetronic 1107) was thoroughly studied in 10 mM HCl by means of pi-A isotherm, surface tension, and pyrene fluorescence measurements. The size and size distribution of the aggregates were investigated by dynamic and static light scattering, and the morphology was probed by transmission electron microscopy. The abilities of the different derivatives to solubilize the drug simvastatin were also evaluated. Poloxamines with both higher PO/EO ratio and molecular weight (T1301 and T150R1) led to micelles with larger and more hydrophobic cores, particularly adequate for hosting hydrophobic molecules and protecting the labile lactone form of simvastatin from hydrolysis. On the other hand, the hydroxy acid form of simvastatin interacted with the central ethylenediamine group under alkaline pH (T304) or when a permanent positive charge due to methylation was present. Micelles of long poloxamine molecules containing large PPO blocks (with 23-29 units, namely, T1301, T1307, and T150R1), particularly the one that also has long PEO blocks, were the most physically stable toward dilution.
Normal-Tension Glaucoma Has Normal Intracranial Pressure (2017)

There was no evidence of reduced ICP in NTG patients as compared with healthy controls, either in supine or in upright position. Consequently, the hypothesis that NTG is caused by an elevated TLCPD from low ICP was not supported.
A 0.8V CMOS analog decoder for an (8,4,4) extended Hamming code (2004)

A soft decoding method for iterative error control codes is through the use of analog circuits. Analog decoders exploit the nonlinear behaviour of transistors operating in subthreshold to process probability information. This paper describes the design of an (8,4,4) extended Hamming decoder operating at supply voltage 0.8V using 0.18/spl mu/m CMOS technology. When normalizers are biased at 1/spl mu/A, a decoding rate of 444 kbps and energy per decoded bit of 0.64nJ/b is achieved.
Enrichment, Isolation, and Phylogenetic Identification of Polycyclic Aromatic Hydrocarbon-Degrading Bacteria from Elizabeth River Sediments (2007)

The diversity of indigenous bacteria in sediments from several sites in the Elizabeth River (Virginia) able to degrade multiple polycyclic aromatic hydrocarbons (PAHs) was investigated by the use of classical selective enrichment and molecular analyses. Enrichment cultures containing naphthalene, phenanthrene, fluoranthene, or pyrene as a sole carbon and energy source were monitored by denaturing gradient gel electrophoresis (DGGE) to detect changes in the bacterial-community profile during enrichment and to determine whether the representative strains present were successfully cultured. The DGGE profiles of the final enrichments grown solely on naphthalene and pyrene showed no clear relationship with the site from which the inoculum was obtained. The enrichments grown solely on pyrene for two sample sites had >80% similarity, which suggests that common pyrene-degrading strains may be present in these sediments. The final enrichments grown on fluoranthene and phenanthrene remained diverse by site, suggesting that these strains may be influenced by environmental conditions. One hundred and one isolates were obtained, comprising representatives of the actinomycetes and alpha-, beta-, and gammaproteobacteria, including seven novel isolates with 16S rRNA gene sequences less than 98% similar to known strains. The ability to degrade multiple PAHs was demonstrated by mineralization of 14C-labeled substrate and growth in pure culture. This supports our hypothesis that a high diversity of bacterial strains with the ability to degrade multiple PAHs can be confirmed by the combined use of classical selective enrichment and molecular analyses. This large collection of diverse PAH-degrading strains provides a valuable resource for studies on mechanisms of PAH degradation and bioremediation.
Attomole-Level Protein Fingerprinting Based on Intrinsic Peptide Fluorescence (2001)

Protein identification has relied heavily on proteolytic analysis, but current techniques are often slow and generally consume large quantities of valuable protein sample. We report the development of a rapid, ultralow volume protein analysis strategy based on tryptic digestion within the tip of a 1.5-microm capillary channel followed by separation of the proteolytic fragments using capillary electrophoresis (CE). Two-photon excitation is used to probe the intrinsic fluorescence of peptide fragments through "deep-UV" excitation of aromatic amino acid residues at the outlet of the CE channel. Detection limits using this technique are 0.7, 2.4, and 23 amol for the aromatic amino acids tryptophan, tyrosine, and phenylalanine, respectively. In these studies, we demonstrate the capacity to differentiate bovine and yeast cytochrome c variants using less than 15 amol of protein through tryptic fingerprinting. Moreover, the detection of a single amino acid substitution between bovine and canine cytochrome c illustrates the sensitivity of this approach to minor differences in protein sequence. The 2-pL sample volume required for this on-column tryptic digestion is, to our knowledge, the smallest yet reported for a proteolytic assay.
Magnetic resonance studies of fredericamycin A: evidence for oxygen-dependent free-radical formation (1986)

Fredericamycin A, a newly described potent antitumor antibiotic, exhibits unusual spectroscopic and physical properties. The drug shows a striking color change from red to blue on exposure to O2, with the appearance of an optical absorption band at 675 nm; on addition of acid these changes are readily reversed. 1H and 13C NMR spectra of fredericamycin A show that the resonances from the quininoid half of the molecule disappear after exposure to O2 but reappear on acidification in parallel with the observed optical spectral shift. These unusual NMR data are explained by electron spin resonance studies which demonstrate that fredericamycin A spontaneously forms an oxidized free radical with electron transfer to O2. The observed hyperfine structure of this radical is consistent with one-electron oxidation of the quininoid group. After fredericamycin A is exposed to O2, an EPR signal is observed with axial symmetry with temperature and power saturation behavior suggestive of .O2-. Spin-trapping EPR studies demonstrate that the drug reduces O2 to .O2- and H2O2 to .OH. This spontaneous mechanism of O2 reduction with the generation of oxidized drug free radicals and reduced oxygen free radicals is unprecedented among anticancer drugs, suggesting that fredericamycin A could be the forerunner of a new class of anticancer drug.
Modulation of integrin antagonist signaling by ligand binding of the heparin‐binding domain of vitronectin to the αVβ3 integrin (2008)

The interaction between the arginine glycine and aspartic acid motif (RGD) of integrin ligands such as vitronectin and the integrin receptor alphaVbeta3 in mediating cell attachment has been well described. Similarly, the ability of disintegrins, small RGD containing peptides, to inhibit cell attachment and other cellular processes has also been studied extensively. Recently, we characterized a second site of interaction between vitronectin and its integrin partner. We determined that amino acids within the heparin-binding domain of vitronectin bind to a cysteine loop (C-loop) region of beta3 and that this interaction is required for the positive effects of alphaVbeta3 ligand occupancy on IGF-I signaling in smooth muscle cells. In this study we examine the signaling events activated following ligand binding of disintegrins to the alphaVbeta3 and the ability of these signals to be regulated by binding of the heparin-binding domain of vitronectin. We demonstrate that disintegrin ligand binding activates a series of events including the sequential activation of the tyrosine kinases c-Src and Syk. This leads to the activation of calpain and the cleavage of the beta3 cytoplasmic tail. Addition of vitronectin or a peptide homologous to the heparin-binding domain inhibited activation of this pathway. Our results suggest that the signaling events that occur following ligand binding to the alphaVbeta3 integrin reflects a balance between the effects mediated through the RGD binding site interaction and the effects mediated by the heparin binding site interaction and that for intact vitronectin the effect of the heparin-binding domain predominates.
Vertical thermal O<sup>+</sup> flows at 850 km in dynamic auroral boundary coordinates (2010)

Contemporary magnetosphere models now include species‐dependent dynamics. Energetic O + has significant consequences for the energy stored in the ring current, the rate of reconnection, and perhaps the timing of substorm injections. The mechanism by which thermal O + escapes from the top of the ionosphere and into the magnetosphere is not fully understood. Previous studies have used dynamic auroral boundary coordinates to describe the outflowing energetic O + ions above the ionosphere. In this study we focus on the vertical flow of O + ions at lower altitudes before they are accelerated to escape velocity. An algorithm has been devised to identify auroral zone boundaries using precipitating electron observations from the Defense Meteorological Satellite Program (DMSP) spacecraft. Vertical ion flows measured by the DMSP special sensor for ions electrons and scintillation ion drift meter and the retarding potential analyzer instruments aboard the F12 (noon‐midnight) and F13 (dawn‐dusk) spacecraft from 1997 to 1998 were projected into dynamic auroral boundary coordinates and used to investigate the dependence of Southern Hemisphere bulk flows on interplanetary magnetic field (IMF) and geomagnetic conditions. Initial results show that (1) net upward flows occur primarily in the auroral zone and net downward flows occur primarily in the polar cap, (2) there exists a strong upward flow at 9 magnetic local time (MLT) near the polar cap boundary, 3) the downward ion flow orientation is strongly dependent on IMF By, and 4) the auroral boundary does not coincide exactly with the upward/downward boundary for bulk flows.
Advanced materials for 193-nm resists (2000)

Acrylate monomers containing alicyclic side chains featuring a series of polar substituent groups were assumed to be model compounds. Solubility parameters were calculated for the corresponding acrylate polymers. These acrylate monomers were synthesized using a novel aerobic oxidation reaction employing N-hydroxyphtalimide (NHPI) as a catalyst, and then polymerized. These reactions were confirmed to be applicable for the mass-production of those compounds. The calculation results agreed with the hydrophilic parameters measured experimentally. Moreover, the relationship between the resist performance and the above-mentioned solubility parameter has been studied. As a result, a correlation between the resist performance and the calculated solubility parameter was observed. Finally, resolution of 0.13-micron patterns, based on the 1G DRAM design rule, could be successfully fabricated by optimizing the solubility parameter and the resist composition.
Purification of Mouse Interferon by Affinity Chromatography on Anti-Interferon Globulin-Sepharose (1973)

Abstract Mouse interferon produced in L cells was subjected to affinity chromatography on Sepharose-bound anti-interferon globulin. The hyperimmune anti-interferon serum was specifically adsorbed to remove antibodies against proteins derived from normal L cells, medium, and inducer virus preparation. The method permitted selective elimination of identified contaminant antigens from crude interferon preparations. Recovery of interferon was quantitative, and purification during this step was from 20- to 50-fold. Specific activities in peak fractions ranged from 1 to 2.7 × 108 National Institutes of Health reference units per mg protein. Interferons induced by irradiated Newcastle disease virus and poly I:C were purified to the same degree.
The available bit rate service for data in ATM networks (1996)

The authors describe the purpose of the available bit rate (ABR) service in the context of other ATM services and review the agreements on the traffic control mechanism. They describe the recent progress towards standardization of the new service. The general nature of the ABR service is described in comparison with constant bit rate (CBR) and variable bit rate (VBR) services.
Development of New PDC Bits for Drilling of Geothermal Wells—Part 1: Laboratory Testing (1992)

Rock cutting, drilling and durability tests were conducted in order to obtain data to design polycrystalline diamond compact (PDC) bits for geothermal well drilling. Both conventional and new PDC bits with different rake angles were tested. The rock cutting tests revealed that cutting forces were minimized at −10 deg rake angle independent of rock type. In drilling and durability tests, a bit with backrake and siderake angles of −10 or −15 deg showed better performance concerning the penetration rate and the cutter strength. The new PDC bit exhibited better performance as compared to the conventional one, especially in hard rock drilling. Furthermore, a new PDC core bit (98.4 mm o. d., 66 mm i. d.) with eight cutters could be successfully applied to granite drilling equally as well as a bit with twelve cutters.
Wafer Defect Detection Using Directional Morphological Gradient Techniques (2002)

Accurate detection and classification of wafer defects constitute an important component of the IC production process because together they can immediately improve the yield and also provide information needed for future process improvements. One class of inspection procedures involves analyzing surface images. Because of the characteristics of the design patterns and the irregular size and shape of the defects, linear processing methods, such as Fourier transform domain filtering or Sobel edge detection, are not as well suited as morphological methods for detecting these defects. In this paper, a newly developed morphological gradient technique using directional components is applied to the detection and isolation of wafer defects. The new methods are computationally efficient and do not rely on a priori knowledge of the specific design pattern to detect particles, scratches, stains, or missing pattern areas. The directional components of the morphological gradient technique allow direction specific edge suppression and reduce the noise sensitivity. Theoretical analysis and several examples are used to demonstrate the performance of the directional morphological gradient methods.
Push-to-Talk over Bluetooth (2006)

Push-to-Talk over Cellular (PoC) is an emerging service enabling a walkie-talkie-like service over GPRS. An open standard for PoC has been specified by the Open Mobile Alliance (OMA) [1]. OMA PoC is based on an IP/UDP/RTP protocol stack and a client-server based architecture. Group management, floor control1 etc are administered by PoC servers. The systems exploits the SIP signalling capabilities of the IP Multimedia Subsystem (IMS) [2]. The objective of this paper is to propose an outline for a Push-to-Talk (PTT) system that utilizes a Bluetooth scatternet and the Personal Area Networking (PAN) profile for data communications [3], [4]. The proposed system is thus fully independent of cellular networks. A reasonable range of several hundred meters can be obtained with multihop communications between Bluetooth class 1 devices, whose range is up to 100 m. The proposed outline for Push-to-Talk over Bluetooth (PoB) comprises e.g. methods for group formation, network formation, communication, and floor control. The network formation method, which can be utilized in other applications as well, is based on creating a scatternet among a predefined set of devices and on avoiding loops. This approach enables usage of a simple broadcasting based communication method, in which the devices bridging the piconets into a scatternet act as repeaters.
Thermofixation of Dyes on Synthetic‐polymer Fibres and their Blends (1964)

After an introduction outlining the advantages of continuous processing, practical details are given of the vital stage of cloth preparation. Suitable methods and machinery for the process are then considered. The fixation of various classes of dye on synthetic‐polymer and cellulosic fibres, and on their blends, is discussed. Particular attention is given to the behaviour of dyes under thermofixation conditions and the effect of heat on certain synthetic‐polymer fibres is indicated. The dyeing of narrow‐width fabrics by the thermofixation technique is discussed, with reference to suitable equipment. The final section deals with the fixation of pigments on textile fibres and blends by resin‐bonding. The absence of fibre substantivity in this method enables solid dyeings to be produced readily on fibre blends.
Synthesis, conformation, and complexation behavior of 2,9,18,25-Tetraoxa[8.8](1,4)naphthalenophane (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, conformation, and complexation behavior of 2,9,18,25-Tetraoxa[8.8](1,4)naphthalenophaneSteven P. Adams and Howard W. Whitlock Jr.Cite this: J. Org. Chem. 1981, 46, 17, 3474–3478Publication Date (Print):August 1, 1981Publication History Published online1 May 2002Published inissue 1 August 1981https://pubs.acs.org/doi/10.1021/jo00330a018https://doi.org/10.1021/jo00330a018research-articleACS PublicationsRequest reuse permissionsArticle Views549Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Acid-Base-Catalyzed Conversion of Aldohexose into 5-(Hydroxymethyl)-2-furfural<sup>2</sup> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Acid-Base-Catalyzed Conversion of Aldohexose into 5-(Hydroxymethyl)-2-furfural2M. L. MEDNICKCite this: J. Org. Chem. 1962, 27, 2, 398–403Publication Date (Print):February 1, 1962Publication History Published online1 May 2002Published inissue 1 February 1962https://pubs.acs.org/doi/10.1021/jo01049a013https://doi.org/10.1021/jo01049a013research-articleACS PublicationsRequest reuse permissionsArticle Views724Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts