The Lectin Pathway of the Complement System (1996)

Microbiology and ImmunologyVolume 40, Issue 12 p. 887-893 ReviewFree Access The Lectin Pathway of the Complement System Misao Matsushita, Misao Matsushita Department of Biochemistry, Fukushima Medical College, 1-Hikariga-oka, Fukushima, Fukushima, 960-12 JapanSearch for more papers by this author Misao Matsushita, Misao Matsushita Department of Biochemistry, Fukushima Medical College, 1-Hikariga-oka, Fukushima, Fukushima, 960-12 JapanSearch for more papers by this author First published: December 1996 https://doi.org/10.1111/j.1348-0421.1996.tb01156.xCitations: 77AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abbreviations CCP complement control protein C1INH C1 inhibitor CRD carbohydrate recognition domain EGF epidermal growth factor MASP MBP-associated serine protease MBP mannose (or mannan) -binding protein RaRF Ra-reactive factor SCR short consensus repeat REFERENCES 1Anders, E.M., Hartley, C.A., Reading, P.C., and Ezekowitz, R.A.B. 1994. Complement-dependent neutralization of influenza virus by a serum mannose-binding lectin. J. Gen. Virol. 75: 615– 622. CrossrefCASPubMedWeb of Science®Google Scholar 2Arlaud, G.J., and Gagnon, J. 1981. C1r and Cls subcomponents of human complement: two serine proteases lacking the ‘histidine-loop’ disulfide bridge. Biosci. Rep. 1: 779– 784. CrossrefCASPubMedWeb of Science®Google Scholar 3Drickamer, K. 1988. Two distinct classes of carbohydrate-recognition domains in animal lectins. J. Biol. Chem. 263: 9557– 9560. CrossrefCASPubMedWeb of Science®Google Scholar 4Duncan, A.R., and Winter, G. 1988. The binding site for Clq on IgG. Nature 332: 738– 740. CrossrefCASPubMedWeb of Science®Google Scholar 5Endo, Y., Sato, T., Matsushita, M., and Fujita, T. 1996. Exon structure of the gene encoding the human mannose-binding protein-associated serine protease (MASP) light chain: comparison with complement C1r and C1s genes. Int. Immunol. 8: 1355– 1358. CrossrefCASPubMedWeb of Science®Google Scholar 6Epstein, J., Eichbaum, Q., Sheriff, S., and Ezekowitz, R.A.B. 1996. The collectins in innate immunity. Curr. Opin. Immunol. 8: 29– 35. CrossrefCASPubMedWeb of Science®Google Scholar 7Ezekowitz, R.A.B., Day, L., and Herman, G.A. 1988. A human mannose-binding protein is an acute-phase reactant that shares sequence homology with other vertebrate lectins. J. Exp. Med. 167: 1034– 1046. CrossrefCASPubMedWeb of Science®Google Scholar 8Ezekowitz, R.A.B., Kuhlman, M., Groopman, J.E., and Byrn, R.A. 1989. A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus. J. Exp. Med. 169: 185– 196. CrossrefCASPubMedWeb of Science®Google Scholar 9Farries, T.C., and Atkinson, J.P. 1991. Evolution of the complement system. Immunol. Today 12: 295– 300. CrossrefCASPubMedWeb of Science®Google Scholar 10Fujita, T., Taira, S., Kodama, N., Matsushita, M., and Fujita, T. 1995. Mannose-binding protein recognizes glioma cells; in vitro analysis of complement activation on glioma cells via the lectin pathway. Jpn. J. Cancer Res. 86: 187– 192. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 11Garred, P., Madsen, H.O., Hofmann, O., and Svejgaard, A. 1995. Increased frequency of homozygosity of abnormal mannan-binding protein alleles in patients with suspected immunodeficiency. Lancet 346: 941– 943. CrossrefCASPubMedWeb of Science®Google Scholar 12Gigli, I., Porter, R.R., and Sim, R.B. 1976. The unactivated form of the first component of human complement, C1. Biochem. J. 157: 541– 548. CrossrefCASPubMedWeb of Science®Google Scholar 13Hartshorn, K.L., Sastry, K., White, M.R., Anders, E.M., Super, M., Ezekowitz, R.A.B., and Tauber, A.I. 1993. Human mannose-binding protein functions as an opsonin for influenza A viruses. J. Clin. Invest. 91: 1414– 1420. CrossrefCASPubMedWeb of Science®Google Scholar 14Haurum, J.S., Thiel, S., Jones, I.M., Fischer, P.B., Laursen, S.B., and Jensenius, J.C. 1993. Complement activation upon binding of mannan-binding protein to HIV envelope glycoproteins. AIDS 7: 1307– 1313. CrossrefCASPubMedWeb of Science®Google Scholar 15Holmskov, U., Holt, P., Reid, K.B.M., Willis, A.C., Teisner, B., and Jensenius, J.C. 1993. Purification and characterization of bovine mannan-binding protein. Glycobiology 3: 147– 153. CrossrefCASPubMedWeb of Science®Google Scholar 16Holt, P., Holmskov, U., Thiel, S., Teisner, B., Hojrup, P., and Jensenius, J.C. 1994. Purification and characterization of mannan-binding protein from mouse serum. Scand. J. Immunol. 39: 202– 208. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 17Ihara, I., Harada, Y., Ihara, S., and Kawakami, M. 1982. A new complement dependent bactericidal factor found in nonimmune mouse sera: specific binding to polysaccharide of Ra chemotype Salmonella. J. Immunol. 128: 1256– 1260. CASPubMedWeb of Science®Google Scholar 18Ihara, I., Ueda, H., Suzuki, S., and Kawakami, M. 1982. Physicochemical properties of a new bactericidal factor, Ra-reactive factor. Biochem. Biophys. Res. Commun. 107: 1185– 1190. CrossrefCASPubMedWeb of Science®Google Scholar 19Ihara, S., Takahashi, A., Hatsuse, H., Sumitomo, K., Doi, K., and Kawakami, M. 1991. Major component of Ra-reactive factor, a complement-activating bactericidal protein, in mouse serum. J. Immunol. 146: 1874– 1879. CASPubMedWeb of Science®Google Scholar 20Ikeda, K., Sannoh, T., Kawasaki, N., Kawasaki, T., and Yamashina, I. 1987. Serum lectin with known structure activates complement through the classical pathway. J. Biol. Chem. 262: 7451– 7454. CrossrefCASPubMedWeb of Science®Google Scholar 21Ji, Y.-H., Matsushita, M., Okada, H., Fujita, T., and Kawakami, M. 1988. The C4 and C2 but not C1 components of complement are responsible for the complement activation triggered by the Ra-reactive factor. J. Immunol. 141: 4271– 4275. CASPubMedWeb of Science®Google Scholar 22Ji, Y.-H., Fujita, T., Hatsuse, H., Takahashi, A., Matsushita, M., and Kawakami, M. 1993. Activation of the C4 and C2 components of complement by a protease in serum bactericidal factor, Ra reactive factor. J. Immunol. 150: 571– 578. CASPubMedWeb of Science®Google Scholar 23Journet, A., and Tosi, M. 1986. Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r. Biochem. J. 240: 783– 787. CrossrefCASPubMedWeb of Science®Google Scholar 24Kawakami, M., Ihara, I., Ihara, S., Suzuki, A., and Fukui, K. 1984. A group of bactericidal factors conserved by vertebrates for more than 300 million years. J. Immunol. 132: 2578– 2581. CASPubMedWeb of Science®Google Scholar 25Kawasaki, N., Kawasaki, T., and Yamashina, I. 1983. Isolation and characterization of a mannan-binding protein from human serum. J. Biochem. 94: 937– 947. CrossrefCASPubMedWeb of Science®Google Scholar 26Kawasaki, N., Kawasaki, T., and Yamashina, I. 1989. A serum lectin (mannan-binding protein) has complement-dependent bactericidal activity. J. Biochem. 106: 483– 489. CrossrefCASPubMedWeb of Science®Google Scholar 27Kozutsumi, Y., Kawasaki, T., and Yamashina, I. 1980. Isolation and characterization of a mannan-binding protein from rabbit serum. Biochem. Biophys. Res. Commun. 95: 658– 664. CrossrefCASPubMedWeb of Science®Google Scholar 28Koide, N., Muramatsu, T., and Kobata, A. 1979. Studies on mannosyl glycopeptides from normal and transformed cells. J. Biochem. 85: 149– 155. CrossrefCASPubMedWeb of Science®Google Scholar 29Kuge, S., Ihara, S., Watanabe, E., Watanabe, M., Takishima, K., Suga, T., Mamiya, G., and Kawakami, M. 1992. cDNAs and deduced amino acid sequences of subunits in the binding component of mouse bactericidal factor, Ra-reactive factor: similarity to mannose-binding proteins. Biochemistry 31: 6943– 6950. CrossrefCASPubMedWeb of Science®Google Scholar 30Kuhlman, M., Joiner, K., and Ezekowitz, R.A.B. 1989. The human mannose-binding protein functions as an opsonin. J. Exp. Med. 169: 1733– 1745. CrossrefCASPubMedWeb of Science®Google Scholar 31Kurata, H., Cheng, H.-e. M., Kozutsumi, Y., Yokota, Y., and Kawasaki, T. 1993. Role of the collagen-like domain of the human serum mannan-binding protein in the activation of complement and the secretion of this lectin. Biochem. Biophys. Res. Commun. 191: 1204– 1210. CrossrefCASPubMedWeb of Science®Google Scholar 32Kusumoto, H., Hirosawa, S., Salier, J.P., Hagen, F.S., and Kurachi, K. 1988. Human genes for complement components C1r and C1s in a close tail-to-tail arrangement. Proc. Natl. Acad. Sci. U.S.A. 85: 7307– 7311. CrossrefCASPubMedWeb of Science®Google Scholar 33Laursen, S.B., Hedemand, J.E., Thiel, S., Willis, A.C., Skriver, E., Madsen, P.S., and Jensenius, J.C. 1995. Collectin in a non-mammalian species: isolation and characterization of mannan-binding protein (MBP) from chicken serum. Glycobiology 5: 553– 561. CrossrefCASPubMedWeb of Science®Google Scholar 34Lipscombe, R.J., Sumiya, M., Hill, A.V.S., Lau, Y.L., Levinsky, R.J., Summerfield, J.A., and Turner, M.W. 1992. High frequencies in African and non-African populations of independent mutation in the mannose binding protein gene. Hum. Mol. Gen. 1: 709– 715. CrossrefCASPubMedGoogle Scholar 35Lu, J., Thiel, S., Wiedemann, H., Timpl, R., and Reid, K.B.M. 1990. Binding of the pentamer/hexamer forms of mannan-binding protein to zymosan activates the proenzyme C1r2C1s2 complex, of the classical pathway of complement, without involvement of C1q. J. Immunol. 144: 2287– 2294. CASPubMedWeb of Science®Google Scholar 36Lytus, S.P., Kurachi, K., Sakariassen, K., and Davie, E.W. 1986. Nucleotide sequence of the cDNA coding for human complement Clr. Biochemistry 25: 4855– 4863. CrossrefPubMedWeb of Science®Google Scholar 37Mackinnon, C.M., Carter, P.E., Smyth, S.J., Dunbar, B., and Fothergill, J.E. 1987. Molecular cloning of cDNA for human complement component C1s. Eur. J. Biochem. 169: 547– 553. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 38Madsen, H.O., Garred, P., Kurtzhals, J.A.L., Lamm, L.U., Ryder, L.P., Thiel, S., and Svejgaard, A. 1994. A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics 40: 37– 44. CrossrefCASPubMedWeb of Science®Google Scholar 39Malhotra, R., Wormald, M.R., Rudd, P.M., Fischer, P.B., Dwek, R.A., and Sim, R.B. 1995. Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein. Nature Med. 1: 237– 243. CrossrefCASPubMedWeb of Science®Google Scholar 40Matsushita, M., and Fujita, T. 1992. Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease. J. Exp. Med. 176: 1497– 1502. CrossrefCASPubMedWeb of Science®Google Scholar 41Matsushita, M., Takahashi, A., Hatsuse, H., Kawakami, M., and Fujita, T. 1992. Human mannose-binding protein is identical to a component of Ra-reactive factor. Biochem. Biophys. Res. Commun. 183: 645– 651. CrossrefCASPubMedWeb of Science®Google Scholar 42Matsushita, M., Ezekowitz, R.A.B., and Fujita, T. 1995. The Gly → Asp allelic form of human mannose-binding protein (MBP) fails to bind MBP-associated serine protease. Biochem. J. 311: 1021– 1023. CrossrefCASPubMedWeb of Science®Google Scholar 43Matsushita, M., and Fujita, T. 1995. Cleavage of the third component of complement (C3) by mannose-binding protein-associated serine protease (MASP) with subsequent complement activation. Immunobiology 194: 443– 448. CrossrefCASPubMedWeb of Science®Google Scholar 44Matsushita, M., and Fujita, T. 1996. The lectin pathway. Res. Immunol. 147: 115– 118. CrossrefCASPubMedWeb of Science®Google Scholar 45Matsushita, M., and Fujita, T. MASP (MBP-associated serine protease). In R.A.B. Ezekowitz, K. Sastry, and K.B.M. Reid (eds), Collectins and innate immunity, R.G. Landes Co., Austin. (in press). Google Scholar 46McKusick, V.A. 1992. Mendelian inheritance in man, 10th ed, p. 1737 and p. 225, Johns Hopkins University Press, Baltimore. Google Scholar 47Muramatsu, T., Gachelin, G., and Jacob, F. 1980. High-mannose glycopeptides from embryonal carcinoma cells. J. Biochem. 88: 685– 688. CASPubMedWeb of Science®Google Scholar 48Ogata, R.T., Low, P.J., and Kawakami, M. 1995. Substrate specificities of the protease of mouse serum Ra-reactive factor. J. Immunol. 154: 2351– 2357. CASPubMedWeb of Science®Google Scholar 49Ohta, M., Okada, M., Yamashina, I., and Kawasaki, T. 1990. The mechanism of carbohydrate-mediated complement activation by the serum mannan-binding protein. J. Biol. Chem. 265: 1980– 1984. CASPubMedWeb of Science®Google Scholar 50Oka, S., Ikeda, K., Kawasaki, T., and Yamashina, I. 1988. Isolation and characterization of two distinct mannan-binding proteins from rat serum. Arch. Biochem. Biophys. 260: 257– 266. CrossrefCASPubMedWeb of Science®Google Scholar 51Reid, K.B.M., Bently, D.R., Cambell, R.D., Chung, L.P., and Sim, R.B. 1986. Complement system proteins which interact with C3b and C4b. A superfamily of structurally related proteins. Immunol. Today 7: 230– 234. CrossrefCASPubMedWeb of Science®Google Scholar 52Sato, T., Endo, Y., Matsushita, M., and Fujita, T. 1994. Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein. Int. Immunol. 6: 665– 669. CrossrefCASPubMedWeb of Science®Google Scholar 53Schweinle, J.E., Ezekowitz, R.A.B., Tenner, A.J., Kuhlman, M., and Joiner, K.A. 1989. Human mannose-binding protein activates the alternative complement pathway and serum bactericidal activity on a mannose-rich isolate of Salmonella. J. Clin. Invest. 84: 1821– 1829. CrossrefCASPubMedWeb of Science®Google Scholar 54Sumiya, M., Super, M., Tabona, P., Levinsky, R.J., Arai, T., Turner, M.W., and Summerfield, J.A. 1991. Molecular basis of opsonic defect in immunodeficient children. Lancet 337: 1569– 1570. CrossrefCASPubMedWeb of Science®Google Scholar 55Summerfield, J.A., Ryder, S., Sumiya, M., Thursz, M., Gorchein, A., Monteil, M.A., and Turner, M.W. 1995. Mannose binding protein gene mutations associated with unusual and severe infections in adults. Lancet 345: 886– 889. CrossrefCASPubMedWeb of Science®Google Scholar 56Super, M., Thiel, S., Lu, J., Levinsky, R.J., and Turner, M.W. 1989. Association of low levels of mannan-binding protein with common defect of opsonization. Lancet ii: 1236– 1239. CrossrefGoogle Scholar 57Super, M., Gillies, S.D., Foler, S., Sastry, K., Schweinle, J.E., Silverman, V.J., and Ezekowitz, R.A.B. 1992. Distinct and overlapping functions of allelic forms of human mannose-binding protein. Nature Genet. 2: 50– 55. CrossrefCASPubMedWeb of Science®Google Scholar 58Takada, F., Takayama, H., Hatsuse, H., and Kawakami, M. 1994. A new member of the C1s family of component protein found in a bactericidal factor, Ra-reactive factor, in human serum. Biochem. Biophys. Res. Commun. 196: 1003– 1009. CrossrefPubMedWeb of Science®Google Scholar 59Takahashi, A., Takayama, Y., Hatsuse, H., and Kawakami, M. 1993. Presence of a serine protease in the complement-activating component of the complement-dependent bactericidal factor, RaRF, in mouse serum. Biochem. Biophys. Res. Commun. 190: 681– 687. CrossrefCASPubMedWeb of Science®Google Scholar 60Takayama, Y., Takada, F., Takahashi, A., and Kawakami, M. 1994. A 100-kDa protein in the C4-activating component of Ra-reactive factor is a new serine protease having module organization similar to C1r and C1s. J. Immunol. 152: 2308– 2316. CASPubMedWeb of Science®Google Scholar 61Taylor, M.E., Brickell, P.M., Craig, R.K., and Summerfield, J.A. 1989. Structure and evolutionary origin of the gene encoding a human serum mannose-binding protein. Biochem. J. 262: 763– 771. CrossrefCASPubMedWeb of Science®Google Scholar 62Terai, I., Kobayashi, K., Matsushita, M., Fujita, T., and Matsuno, K. 1995. α2-macroglobulin binds to and inhibits mannose-binding protein-associated serine protease. Int. Immunol. 7: 1579– 1584. CrossrefCASPubMedWeb of Science®Google Scholar 63Thiel, S., Vorup-Jensen, T., Laursen, S.B., Willis, A., Reid, K.B.M., Hansen, S., and Jensenius, J.C. 1996. Identification of a new mannan-binding lectin associated serine protease (MASP-2). Mol. Immunol. 33 (Suppl. 1) Abstract: 91. Google Scholar 64Tosi, M., Duponchel, C., Meo, T., and Julier, C. 1987 Complete cDNA sequence of human complement C1s and close physical linkage of the homologous genes C1r and C1s. Biochemistry 26: 8516– 8524. Google Scholar 65Turner, M.W. 1996. The lectin pathway of complement activation. Res. Immunol. 147: 110– 115. CrossrefCASPubMedWeb of Science®Google Scholar 66Van Cong, N., Tosi, M., Cohen-Haguenauer, O., Jegou-Foubert, C., de Tnad, M.F., Meo, T., and Frezal, J. 1988. Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13. Hum. Genet. 78: 363– 368. CrossrefPubMedGoogle Scholar 67Weis, W.I., Drickamer, K., and Hendrickson, W.A. 1992. Structure of a C-type mannose-binding protein complexed with an oligosaccharide. Nature 360: 127– 134. CrossrefCASPubMedWeb of Science®Google Scholar Citing Literature Volume40, Issue12December 1996Pages 887-893 ReferencesRelatedInformation