gebhart/patrepeval huggingface dataset:
Mapping the membrane proteome of <b><i>Corynebacterium glutamicum</i></b> (2005)

In order to avoid the specific problems with intrinsic membrane proteins in proteome analysis, a new procedure was developed which is superior to the classical two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) method in terms of intrinsic membrane proteins. For analysis of the membrane proteome from Corynebacterium glutamicum, we replaced the first separation dimension, i.e., the isoelectric focusing step, by anion-exchange chromatography, followed by sodium dodecyl sulfate (SDS)-PAGE in the second separation dimension. Enrichment of the membrane intrinsic subproteome was achieved by washing with 2.5 M NaBr which removed more than 35% of the membrane-associated soluble proteins. For the extraction and solubilization of membrane proteins, the detergent amidosulfobetaine 14 (ASB-14) was most efficient in a detailed screening procedure and proved also suitable for chromatography. 356 gel bands were spotted, and out of 170 different identified proteins, 50 were membrane-integral. Membrane proteins with one up to 13 transmembrane helices were found. Careful analysis revealed that this new procedure covers proteins from a wide pI range (3.7-10.6) and a wide mass range of 10-120 kDa. About 50% of the identified membrane proteins belong to various functional categories like energy metabolism, transport, signal transduction, protein translocation, and proteolysis while for the others a function is not yet known, indicating the potential of the developed method for elucidation of membrane proteomes in general.
Undergraduates Writing Publishable Cases: The Trials, The Tribulations, And The Real-World Learning (2011)

If given the chance, undergraduates have the ability to write excellent case studies worthy of being published. This essay describes the benefits, challenges, and process of undergraduate case writing.
Session Description Protocol (SDP) Source Filters (2006)

This document describes how to adapt the Session Description Protocol (SDP) to express one or more source addresses as a source filter for one or more destination "connection" addresses. It defines the syntax and semantics for an SDP "source-filter" attribute that may reference either IPv4 or IPv6 address(es) as either an inclusive or exclusive source list for either multicast or unicast destinations. In particular, an inclusive source-filter can be used to specify a Source-Specific Multicast (SSM) session.
3‐D natural interactive interface—using marker tracking from a single view (1992)

Abstract The proliferation of microcomputers and powerful single‐user minicomputers has created an urgent demand for effective man‐computer interface in three‐dimensional (3‐D) space. This paper presented an interface that is able to recognize finger movement by using an image processing from a single view. Two ring‐shaped markers are attached on the fingertip of an index finger and a thumb. Tracking the positions of two markers, six behaviors of the hand are detected. The detected behaviors to manipulate the object are as follows: catch the object, x translation, y translation, z translation, rotation in the horizontal plane, and rotation in the vertical plane. The image of the current hand and the object presented by wire‐frame is projected on CRT in real time. The operator is able to manipulate the object moving the hand within the view of the TV camera. Because of the foregoing six motions set equivalent to the motions exactly as done in daily life, an operator can maintain a natural interaction with a computer.
The synthesis of some 2,4‐benzodiazepin‐1‐ones, potent C.N.S. agents (1975)

Abstract The synthesis of 2,4‐benzodiazepin‐1‐ones (II, V) has been accomplished. Their C.N.S. properties are of the same order of the well known 1,4‐benzodiazepins (Valium).
Si‐Compatible Ion‐Selective Oxide Interconnects with High Tunability (2004)

A new class of porous oxide interconnects with a regularly perforated SiN support structure is presented here. The method is demonstrated by constructing γ‐alumina, MCM‐48 silica (see Figure), and amorphous titania interconnects. Ionic transport through the gate is established by externally varying the potential difference across the interconnects, which allows cationic, anionic, or no transport, depending on the magnitude and sign of the applied potential difference.
Palladium-catalysed 1,4-arylation/alkylation of buta-1,3-diene with halogenoarenes and stabilised anions (1990)

In the presence of a palladium–phosphine catalyst, buta-1,3-diene reacts with halogenoarenes and –CH(CN)2 to give 1,4-arylation/alkylation products of the diene, ArCH2CHCHCH2C(Ar)(CN)2(6), in moderate yields. In this reaction, two carbon–carbon bonds are built up from three components by a tandem insertion/coupling reaction in one catalytic cycle. Stabilised anions such as –CH(CN)CO2Me and –CH(CO2Et)2 similarly yield 1,4-arylation/alkylation products.
Design of a novel mobility device controlled by the feet motion of a standing child (2011)

Self-generated mobility is a major contributor to the physical, emotional, cognitive, and social development of infants and toddlers. When young children have disorders that hinder self locomotion, their development is at risk for delay. Independent mobility via traditional power mobility devices may prevent this delay, but do little to encourage the child's development of gross motor skills. This research aims to develop a bio-driven mobile-assistive device that is controlled and driven by moving the feet, which may encourage the development of gross motor skills. In this study, system feasibility is shown by experiments on five typically developing toddlers and one special needs toddler with spastic cerebral palsy. Children were placed in the bio-driven device and instructed to navigate through a maze. All subjects were able to successfully complete the maze in multiple trials. Additionally, two toddlers showed evidence of improved driving skill by completing the maze in shorter times in successive trials on a given testing day. The results suggest that such a device is feasible for purposeful driving. Recommendations are given for the device and protocol redesign for related future testing.
Photonic bandgap tuning with thermo-optic effect (2004)

Tuning of photonic bandgap was demonstrated with thermo-optic effect. A 2.7-nm wavelength-shift was obtained at 48 mW heating power. Optic switching by shifting photonic bandgap was realized with an extinction ratio of 13 dB.
Prognostic Value of Biventricular Strain in Risk Stratifying in Patients With Acute Heart Failure (2018)

Background Few studies have shown that right ventricular ( RV ) function is independently related to adverse events regardless of left ventricular ( LV ) function in heart failure. We evaluated the prognostic value of global longitudinal strain ( GLS ) of both ventricles in patients with acute heart failure. Methods and Results We measured biventricular strains in 1824 randomly selected patients (973 men, aged 70±14 years) from a strain registry. A total of 799 patients (43.8%) died during the median follow-up duration of 31.7 months. In univariate analysis, LVGLS and RVGLS were significantly associated with all-cause mortality. We classified them into 4 strain groups according to LVGLS (≥9%) and RVGLS (≥12%). On Cox proportional hazards analysis, group 4 (<9% LVGLS and <12% RVGLS ) had the worst prognosis, with a hazard ratio ( HR ) of 1.755 (95% confidence interval [ CI ], 1.473-2.091; P<0.001) compared with that of group 1 (≥9% LVGLS and ≥12% RVGLS ). After multivariate analysis, both LVGLS (per 1% decrease; HR : 1.057; 95% CI , 1.029-1.086; P<0.001) and RVGLS (per 1% decrease; HR : 1.022; 95% CI , 1.004-1.040; P=0.014) were also significant. The HR of RVGLS <12% was higher in patients without pulmonary hypertension (assessed by maximal tricuspid regurgitation ≤2.8 m/s) after the adjustment of LVGLS ( HR : 1.40 [95% CI , 1.11-1.77] versus 1.07 [95% CI , 0.88-1.30] with pulmonary hypertension; interaction, P=0.043). Conclusions In the patients with acute heart failure, RVGLS was significantly associated with all-cause mortality regardless of LVGLS , and those with decreased biventricular GLS showed the worst prognosis. The predictive power of RVGLS was more prominent in the absence of pulmonary hypertension.
Suspicion scoring based on guilt-by-association, colle ctive inference, and focused data access 1 (2005)

We describe a guilt-by-association system that can be use d to rank entities by their suspiciousness. We demonstra te the algorithm on a suite of data sets generated by a terror istworld simulator developed under a DoD program. The data sets consist of thousands of people and some known links between them. We show that the system ranks truly malicious individuals highly, even if only relatively few are known to be malicious ex ante. When used as a tool for identifying promising data-gathering opportunities, the system focuses on gathering more information about the most suspicious people and thereby increases the density of link age in appropriate parts of the network. We assess performance under conditions of noisy prior knowledge (score quality varies by data set under moderate noise), and whether augmenting the network with prior scores based on profiling information improves the scoring (it doesn’t). Al though the level of performance reported here would not support direct action on all data sets, it does recommend th e consideration of network-scoring techniques as a new source of evidence in decision making. For example, the system can operate on networks far larger and more complex than could be processed by a human analyst .
A Novel UHV/EHV Transmission-Line Pilot Protection Based on Fault Component Integrated Impedance (2010)

Based on the ratio of the sum of the fault component voltage phasors across the two terminals in the transmission line to the sum of the current phasors through the same line, which is defined as fault component integrated impedance in this paper, a new transmission-line pilot protection principle is proposed. When an external fault occurs, the amplitude of the fault component integrated impedance that reflects the capacitance impedance of the line becomes large; When an internal fault occurs, the amplitude of the fault component integrated impedance which reflects the impedance of the system source and the line, becomes relatively small. Therefore, the fault in the line can be detected according to this characteristic. The criterion is not affected by the current through the capacitance and is not affected by the fault resistance. It can be applied to the line with or without shunt reactor. Also, it can be easily set. Both the simulation results with Electromagnetic Transients Program and dynamic model data verify the validity of the proposed principle.
Acute kidney injury: an overview of pathophysiology and treatments. (2011)

Acute kidney injury, or acute kidney failure, is thought to complicate 5% of hospital admissions (Cheung, Ponnusamy, & Anderton, 2008). Most healthcare providers are likely to encounter patients experiencing acute kidney injury. Nurses and other healthcare professionals can play a vital role in identifying patients at risk for acute kidney injury and aid early intervention by identifying decreased kidney function. This article summarizes the current literature on acute kidney injury, including the definition, pathophysiology, risk factors, diagnostic tests, and current treatments and interventions.
Tibial Plateau Leveling Osteotomy or Tibial Tuberosity Advancement? (2008)

TPLO and TTA are effective at returning dogs with a CrCL-deficient stifle joint to good limb function. Surgeon discretion and case selection drive selection of TPLO or TTA based mostly on anecdotal evidence and personal experience.
Computer Graphics: An Object-Oriented Approach to the Art and Science Implemented in C++ (1995)

From the Publisher:
This book presents the principles behind the art and science of computer graphics within an object-oriented context. Included are examples of multiple algorithms for generating images and all C++ source codes on diskette.
The role of desmoglein 2 and E-cadherin in the invasion and motility of human breast cancer cells (1997)

Loss of adhesion is a fundamental step in the metastatic cascade. Desmosomal cadherins, Desmoglein (Dsg) and Desmocollin (Dsc) are a novel group of adhesion molecules. Aims were to demonstrate expression of Dsg2 and E-cadherin in breast cancer cells and assess their role in invasion and motility. Immunofluorescence and Western blotting were used to demonstrate expression of Dsg2 and E-cadherin in 3 breast cancer cell lines (MDA MB 231, MCF7 and BT474). Functional studies included cell-cell aggregation, in vitro invasion and colloidal gold phagokinetic tracking assays. All 3 cell lines expressed Dsg2. MCF7 and BT474 cells were E-cadherin positive, MDA 231 was negative. Cell aggregation was reduced, in vitro invasion and motility were increased in Dsg2 or E-cadherin Mab pre-treated cells. Dsg2 present in breast cancer cells may act as a tumour suppressor molecule.
ChemInform Abstract: New Strategies for the Synthesis of Unmodified and Modified Oligonucleotides (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Do cinema ao arquivo: traçando o percurso migratório dos filmes de família (2012)

The use of family and amateur films in differents audiovisual\nproductions is a tendency that has intensified specially over the last two decades. In this\nessay I propose to retrace the course of these archival images that come from the private\nworld and go into a public space, adapted by filmmakers.
Statistical models for unsupervised prepositional phrase attachment (1998)

We present several unsupervised statistical models for the prepositional phrase attachment task that approach the accuracy of the best supervised methods for this task. Our unsupervised approach uses a heuristic based on attachment proximity and trains from raw text that is annotated with only part-of-speech tags and morphological base forms, as opposed to attachment information. It is therefore less resource-intensive and more portable than previous corpus-based algorithm proposed for this task. We present results for prepositional phrase attachment in both English and Spanish.
A survey of introductory and advanced programming courses (1974)

In the process of establishing equitable and practical computer time allocations for our computer science courses this fall, we compared our seemingly high request with standards in other universities. Twenty-three private and state universities were chosen for the comparison and a questionnaire (appendix 1) was designed to elicit information about large introductory programming courses and more specialized systems programming/software engineering courses.
Cyclosporin binding to a protein component of the renal Na(+)-D-glucose cotransporter. (1990)

The immunosuppressive and nephrotoxic agent cyclosporin binds to a renal polypeptide with an apparent molecular weight of 75,000 which has been identified as a component of the renal Na(+)-D-glucose cotransporter (Neeb, M., Kunz, U., and Koepsell, H. (1987) J. Biol. Chem. 262, 10718-10729). The same Mr 75,000 polypeptide was covalently labeled with the D-glucose analog 10-N-(bromoacetyl)amino-1-decyl-beta-D-glucopyranoside and with the cyclosporin analog N epsilon-(diazotrifluoroethyl)benzyl-D-Lys8- cyclosporin (CSDZ). CSDZ labeling was decreased when the brush-border membrane proteins were incubated with monoclonal antibodies against the Na(+)-D-glucose cotransporter. In the presence of 145 mM Na+, CSDZ labeling was decreased by D-glucose (1 microM, 1 mM, or 100 mM) and by phlorizin (100 or 500 microM). In the absence of Na+, CSDZ labeling was distinctly increased by 50 microM phlorizin and was slightly increased by 1 mM D-glucose, whereas CSDZ labeling was decreased by 50 microM phloretin and by 500 microM phlorizin. Furthermore, Na(+)-dependent high affinity phlorizin binding to the Na(+)-D-glucose cotransporter was competitively inhibited by cyclosporin A (Ki = 0.04 microM) while Na(+)-D-glucose cotransport was not influenced. The data suggest that a part of the cyclosporin binding domain on the Na(+)-D-glucose cotransporter is identical to the phloretin binding domain of the high affinity phlorizin binding site. While phloretin or the phloretin moiety of phlorizin may directly displace cyclosporin, interaction of D-glucose or of the D-glucose moiety of phlorizin with the transporter may alter the conformation of the cyclosporin binding site and this conformational change may be modulated by Na+.
Stream synthesis for efficient power simulation based on spectral transforms (2001)

One way of minimizing the time required to perform simulation-based power estimation is that of reducing the length of the input trace to be fed to the simulator. Obviously, the use of a reduced stream may introduce some errors in the estimation results. The generation (or synthesis) of the short input sequence to be used for power simulation should then be carried out in such a way that the resulting error is minimized. Existing techniques exploit the knowledge of some statistical and correlation characteristics concerning the original input trace to generate a reduced stream that closely matches such characteristics. In this paper, we introduce a new stream synthesis method. Its distinguishing feature is the use of spectral analysis based on the discrete Fourier transform to determine a reduced sequence of vectors that enables us to shorten the overall power simulation time at a very limited penalty in accuracy. The effectiveness and the robustness, in terms of estimation accuracy, of the proposed synthesis procedure are demonstrated by the experimental results we have obtained on standard combinational benchmarks for a variety of input streams with different statistical and correlation properties. Data for sequential circuits are also reported.
T2 Relaxation Time Versus Mercury Injection Capillary Pressure: Implications for NMR Logging and Reservoir Characterisation (1998)

Abstract A link between distributions of T2 relaxation time and capillary pressure curves has been demonstrated in several articles published over the last few years. Efforts to establish a link have mostly concentrated on high pressure air/mercury experiments (MICP). Establishing a link between T2 and MICP is important because it adds confidence to estimates of bound fluid, free fluid, and permeability from NMR logs. The link also provides another route to saturation height functions. However, experience working with NMR logs has shown that estimates of bound fluid are frequently under or overestimated and the default parameters used to determine bound fluid (e.g. T2 cutoffs) have to be adjusted to compensate for this. Often, little is known about how these adjustments relate to the actual pore system. Analysis of 176 core samples representing a broad spectrum of sandstone reservoirs demonstrates the link between T2 and MlCP is unpredictable. This result challenges use of simplistic pore models for predicting bound fluid and explains why bound fluid estimates from NMR logs are often wrong. However, there is sufficient similarity between data sets for T2/Pc functions to be developed locally from core on a well-by-well basis. These functions can be applied to NMR logs using a process of pattern recognition which identifies similar NMR response type's within logs and core samples. NMR response types and their associated T2/Pc function provide information about upscaling and flow units. P. 323
A structured light-based laparoscope with real-time organs' surface reconstruction for minimally invasive surgery (2012)

In this paper we present a new 3-D laparoscopic device based on structured light for minimally invasive surgery. Real-time reconstruction of internal organs' surfaces is very challenging as the numerous geometric and photometric variabilities and disturbances (bloody parts, specularities, smokes,...) often occur during the surgical operation, sometimes with manipulations by several assistants. We then conceived a structured light vision system to illuminate a coded pattern by means of an external video projector device or miniaturized diffractive optical elements and a laser source. Among the structured light techniques, the spatial neighbourhood scheme is the most relevant class of approaches to deal with moving and deformable surfaces, then to capture the depth map with only one shot. Each neighbourhood (a (3 × 3) window) is representing a codeword of length 9, and is unique in the whole pattern, even if there is a lack of information. To do so, a monochromatic subperfect map-based pattern is computed, driven by a desired minimal Hamming distance, H(min), between any couple of codewords. This provides patterns with high correction capabilities (H(min) > 1). For practical considerations, each numerical codeword symbol is associated to a unique visual feature embedding the local orientation of the pattern, which is helpful for the neighbourhood retrieval during the decoding process. Together with the endoscopic device, in vivo real-time reconstructions (in mini-invasive surgical conditions) are presented to assess both the efficiency of the proposed pattern design, the decoding process and the 3-D laparoscope setup realized in the lab.
Prozone Effect and the Immunoturbidimetric Measurement of Albumin in Urine (1990)

Journal Article Prozone Effect and the Immunoturbidimetric Measurement of Albumin in Urine Get access D R Jury, D R Jury Clin. Chem., Waikato Hosp., Private Bag, Hamilton, NZ Search for other works by this author on: Oxford Academic Google Scholar D J Mikkelsen, D J Mikkelsen Clin. Chem., Waikato Hosp., Private Bag, Hamilton, NZ Search for other works by this author on: Oxford Academic Google Scholar P J Dunn P J Dunn Clin. Chem., Waikato Hosp., Private Bag, Hamilton, NZ Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 36, Issue 8, 1 August 1990, Pages 1518–1519, https://doi.org/10.1093/clinchem/36.8.1518 Published: 01 August 1990
Partial Regeneration of Periodontal Tissues Using Collagen Barriers (1988)

The capacity of collagen membranes to support guided regeneration of periodontal tissues in the dog was assessed. The mesiolabial, labial and distolabial aspects of the mesial root of the second and third mandibular premolar were surgically exposed in three beagle dogs. Collagen membranes, 0.5 to 0.7 mm thick, prepared from a purified solution of rat-Type I collagen were interposed between the gingival flap and the exposed root surfaces of the right premolars. The left premolars were sham-operated without the use of collagen membranes. Animals were killed one month after surgery. Tissue blocks, including the surgical sites, were removed and prepared for histological and histometric examination. Long epithelial attachment was the modality of healing in the control sites. The apical level of the junctional epithelium was located either at, or close to, the apical level of the defect. The experimental sites exhibited a combination of three healing modalities: (1) partial regeneration of periodontal tissues (new bone, periodontal ligament and cementum) occurred in the apical half of the defect, (2) long epithelial attachment developed in the coronal quarter of the defect and (3) connective tissue adhesion developed between the two. Pocket depth was similar in both the control and experimental sites. Collagen membranes could not be identified at the time of examination. The results indicate that: (1) collagen membranes have the capacity to support regeneration of periodontal tissues and (2) collagen membranes are either incorporated within the healing tissues or degraded by these during the healing process. These findings suggest that collagen membranes may be of value in reconstructive periodontal therapy.