gebhart/patrepeval huggingface dataset:
Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines. (1984)

In the human melanoma cell line MM127 , the melphalan survival curve was linear and exhibited reciprocity with respect to concentration and treatment time. The survival curve of an allogeneic line, MM253c1 , exhibited a shoulder and, on a concentration X time basis, was resistant to 1-hr compared with 4-hr treatment. This type of resistance, which was not found using chlorambucil, nitrogen mustard, or methyl methanesulfonate, could be overcome by simultaneous hyperthermia (42 degrees) but not by treatment with thymidine or caffeine. Both lines had similar levels of DNA interstrand cross-linking (perchlorate renaturation method) after 1-hr treatment, but MM253c1 cells were able to repair most of this damage during the next 23 hr. The cross-links formed in MM253c1 cells after 1 hr were predominantly heat sensitive and photoresistant , whereas those formed in MM127 cells were heat resistant and photosensitive. These results suggest that melphalan formed repairable (possibly diadeninyl or adeninyl - guaninyl ) cross-links in MM253c1 cells during the first hr of treatment and nonrepairable , possibly diguaninyl cross-links in MM127 cells at all stages of treatment. It appears therefore that the mode of action of melphalan and the effect of synergistic agents may not be identical in all cells.
Identification of <i>yacE</i> ( <i>coaE</i> ) as the Structural Gene for Dephosphocoenzyme A Kinase in <i>Escherichia coli</i> K-12 (2001)

Dephosphocoenzyme A (dephospho-CoA) kinase catalyzes the final step in coenzyme A biosynthesis, the phosphorylation of the 3'-hydroxy group of the ribose sugar moiety. Wild-type dephospho-CoA kinase from Corynebacterium ammoniagenes was purified to homogeneity and subjected to N-terminal sequence analysis. A BLAST search identified a gene from Escherichia coli previously designated yacE encoding a highly homologous protein. Amplification of the gene and overexpression yielded recombinant dephospho-CoA kinase as a 22.6-kDa monomer. Enzyme assay and nuclear magnetic resonance analyses of the product demonstrated that the recombinant enzyme is indeed dephospho-CoA kinase. The activities with adenosine, AMP, and adenosine phosphosulfate were 4 to 8% of the activity with dephospho-CoA. Homologues of the E. coli dephospho-CoA kinase were identified in a diverse range of organisms.
SERPIN Regulation of Factor XIa (2000)

In the present studies we have made the novel observation that protease nexin 1 (PN1), a member of the serine protease inhibitor (SERPIN) superfamily, is a potent inhibitor of the blood coagulation Factor XIa (FXIa). The inhibitory complexes formed between PN1 and FXIa are stable when subjected to reducing agents, SDS, and boiling, a characteristic of the acyl linkage formed between SERPINs and their cognate proteases. Using a sensitive fluorescence-quenched peptide substrate, the K(assoc) of PN1 for FXIa was determined to be 7.9 x 10(4) m(-)(1) s(-)(1) in the absence of heparin. In the presence of heparin, this rate was accelerated to 1.7 x 10(6), M(-)(1) s(-)(1), making PN1 a far better inhibitor of FXIa than C1 inhibitor, which is the only other SERPIN known to significantly inhibit FXIa. FXIa-PN1 complexes are shown to be internalized and degraded by human fibroblasts, most likely via the low density lipoprotein receptor-related protein (LRP), since degradation was strongly inhibited by the LRP agonist, receptor-associated protein. Since FXIa proteolytically modifies the amyloid precursor protein, this observation may suggest an accessory role for PN1 in the pathobiogenesis of Alzheimer's disease.
A 54-kDa Fragment of the Poly(A)-specific Ribonuclease Is an Oligomeric, Processive, and Cap-interacting Poly(A)-specific 3′ Exonuclease (2000)

We have previously identified a HeLa cell 3' exonuclease specific for degrading poly(A) tails of mRNAs. Here we report on the purification and identification of a calf thymus 54-kDa polypeptide associated with a similar 3' exonuclease activity. The 54-kDa polypeptide was shown to be a fragment of the poly(A)-specific ribonuclease 74-kDa polypeptide. The native molecular mass of the nuclease activity was estimated to be 180-220 kDa. Protein/protein cross-linking revealed an oligomeric structure, most likely consisting of three subunits. The purified nuclease activity released 5'-AMP as the reaction product and degraded poly(A) in a highly processive fashion. The activity required monovalent cations and was dependent on divalent metal ions. The RNA substrate requirement was investigated, and it was found that the nuclease was highly poly(A)-specific and that only 3' end-located poly(A) was degraded by the activity. RNA substrates capped with m(7)G(5')ppp(5')G were more efficiently degraded than noncapped RNA substrates. Addition of free m(7)G(5')ppp(5')G cap analogue inhibited poly(A) degradation in vitro, suggesting a functional link between the RNA 5' end cap structure and poly(A) degradation at the 3' end of the RNA.
Resource-Efficient Replication and Migration of Virtual Machines (2015)

To my father. ii ACKNOWLEDGEMENTS I cannot say enough to thank my advisor, Professor Kang Shin; this thesis would not have been possible without him. He sets an example of continued pursuit of excellence, strong sense of responsibility and hard work. He has provided tremendous support all the years of my graduate study, and has shown me great patience and understanding in the difficult times. His advice on research, career and life has also benefited me immensely. I consider myself truly fortunate to have been his student, and would like to express my deep gratitude to him. I would also like to thank Professors Peter Chen, Jason Flinn and Dawn Tilbury, for serving on my thesis committee, proposing insightful questions and providing invaluable feedback for improving this thesis. The work described in this thesis is not produced by my effort alone. HydraVM, de-scribed in Chapter III, was designed in collaboration with Dr. Arif Merchant, Dr. Mustafa Uysal and Dr. Sharad Singhal. The characterization of checkpoint compression methods
Reviews of Books (1904)

Reviews of Books Get access Die Politik der Niederländer während des Kalmarkriegs (1611–1613) und ihr Bündnis mit Schweden (1614) und den Hansestädten (1616). ERNST Von WIESE. (Heidelberg: Winter. 1903.) A. W. WARD A. W. WARD Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume XIX, Issue LXXV, July 1904, Pages 591–592, https://doi.org/10.1093/ehr/XIX.LXXV.591 Published: 01 July 1904
Extraction, fractionation, and characterization of structural polysaccharides from wheat straw. (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExtraction, fractionation, and characterization of structural polysaccharides from wheat straw.J. Mark Lawther, Runcang Sun, and W. B. BanksCite this: J. Agric. Food Chem. 1995, 43, 3, 667–675Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/jf00051a021https://doi.org/10.1021/jf00051a021research-articleACS PublicationsRequest reuse permissionsArticle Views2746Altmetric-Citations166LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Learning-Aided Unary Error Correction Codes for Non-Stationary and Unknown Sources (2016)

Unary error correction (UEC) codes have recently been proposed for the joint source and channel coding of symbol values that are selected from a set having an infinite cardinality. However, the original UEC scheme requires the knowledge of the source probability distribution, in order to achieve near-capacity operation. This limits the applicability of the UEC scheme, since the source probability distribution is typically non-stationary and is unknown in practice. In this paper, we propose a dynamic version of the UEC scheme, which can learn the unknown source statistics and gradually improve its decoding performance during a transient phase, then dynamically adapt to the non-stationary statistics and maintain reliable near-capacity operation during a steady-state phase, at the cost of only a moderate memory requirement at the decoder. Based on the same learning technique, we also propose two separate source and channel coding benchmarkers, namely, a learning-aided Elias gamma-convolutional code (CC) scheme and a learning-aided arithmetic-CC scheme. The simulation results reveal that our proposed learning-aided UEC scheme outperforms the benchmarkers by up to 0.85 dB, without requiring any additional decoding complexity or any additional transmission-energy, -bandwidth, or -duration.
Effects of Lopap on Human Endothelial Cells and Platelets (2001)

Severe consumption coagulopathy has been detected in rats after Lopap (a prothrombin activator from Lonomia obliqua caterpillar bristles) infusion and in humans after accidental contact with L. obliqua bristles. However, platelet count and antithrombin (AT) levels were only modestly affected, suggesting that a different form of blood coagulation activation may be involved in this hemorrhagic syndrome. Here we describe that Lopap had no effect on aggregation of washed human platelets induced by several agonists, suggesting that it might not impair platelet function in vivo. AT was able to inhibit the amidolytic activity of thrombin generated by incubation of Lopap with prothrombin in a purified system, which may be different from that generated by the prothrombinase complex in vivo. The surface expression of both ICAM-1 and E-selectin but not of VCAM-1 was upregulated by Lopap in cultured HUVEC, suggesting that it may behave differently from other mediators, such as thrombin and tumor necrosis factor-alpha.
Erythrocyte Invasion by Two Plasmodium falciparum Isolates Differing in Sialic Acid Dependency in the Presence of Glycophorin a Antibodies (1989)

Merozoites of Plasmodium falciparum depend on glycophorins for invasion into human erythrocytes, although this dependency varies between different geographic isolates of the species. The FCR-3 (Gambia) isolate appears to be fully dependent on the N-acetylneuraminic acid (NeuNAc) residues of the O-linked tetrasaccharide of glycophorin for invasion. Invasion of the CDC-1 (Honduras) isolate into neuraminidase treated erythrocytes is 50% of that into normal erythrocytes. This and additional results suggest that this isolate is not fully dependent on the O-linked saccharides of glycophorin. In the present study, invasion of CDC-1 and FCR-3 isolates into erythrocytes was examined in the presence of Fab fragments of monoclonal antibodies directed against different domains of glycophorin. Fab fragments directed against the carbohydrate domain inhibited invasion of both isolates but inhibited invasion by the FCR-3 isolate more than CDC-1 isolate. The reactivity of monoclonal antibodies (Mabs) directed against the carbohydrate domain was dependent on the NeuNAc residues as binding was abolished in neuraminidase treated erythrocytes. Mabs directed against the peptide domain of glycophorin A did not significantly inhibit invasion by either isolate. These results are consistent with other findings that the CDC-1 isolate is not fully dependent on the carbohydrate domain of glycophorin for invasion.
Testing in resource constrained execution environments (2005)

Software for resource constrained embedded devices is often implemented in the Java programming language because the Java compiler and virtual machine provide enhanced safety, portability, and the potential for run-time optimization. It is important to verify that a software application executes correctly in the environment in which it will normally execute, even if this environment is an embedded one that severely constrains memory resources. Testing can be used to isolate defects within and establish a confidence in the correctness of a Java application that executes in a resource constrained environment. However, executing test suites with a Java virtual machine (JVM) that uses dynamic compilation to create native code bodies can introduce significant testing time overheads if memory resources are highly constrained. This paper describes an approach that uses adaptive code unloading to ensure that it is feasible to perform testing in the actual memory constrained execution environment. The experiments demonstrate that code unloading can reduce both the test suite execution time by 34% and the code size of the test suite and application under test by 78% while maintaining the overall size of the JVM.
SEPIA: a new isolation structure for soft-error-immune LSIs (1993)

A new isolation structure for soft-error immunity has been developed. This structure, SEPIA (soft-error-preventing isolation by charge absorption), is suitable for advanced ULSIs such as 256-kb bipolar SRAMs. The SEPIA structure combines charge absorption and trench isolation. Experiments and simulations show that SEPIA reduces the amount of alpha-particle-induced charge collected in transistors. Electrons which diffuse in the substrate are absorbed by SEPIA. The collected charge is reduced to 20-30 fC, which is about 1/5 of the charge collected with the conventional structure. With SEPIA the amount of charge collected decreases as the transistor size is scaled down. SEPIA is thus more effective in the small transistors that will be used in advanced ULSIs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Activated Interstitial Myofibroblasts Express Catabolic Enzymes and Mediate Matrix Remodeling in Myxomatous Heart Valves (2001)

Interstitial cells in myxomatous valves have features of activated myofibroblasts and express excessive levels of catabolic enzymes, without altered levels of interstitial collagen mRNA. We conclude that valvular interstitial cells regulate matrix degradation and remodeling in myxomatous mitral valve degeneration.
Temperature Rising Elution Fractionation and Crystallization Analysis Fractionation (2000)

Abstract Temperature rising elution fractionation (TREF) and crystallization analysis fractionation (CRYSTAF) are separation techniques for the characterization of semicrystalline polymers in terms of chemical composition. TREF has become a powerful tool for preparative polymer fractionation and for the analysis of the chemical composition distribution (CCD) in polyolefins. CRYSTAF, a more recent technique and with a simple hardware design, provides a faster approach for the analysis of the CCD. Both TREF and CRYSTAF separate according to the crystallizability of the polymer molecules, which is influenced by tacticity or the comonomer incorporation into the chain. TREF and CRYSTAF are becoming specially relevant in the characterization of the new and complex polyolefins made with combinations of homogeneous and heterogeneous catalysts.
The DNA helicase–primase complex as a target for herpes viral infection (2013)

The outstanding safety profile of existing nucleoside analogues for α-herpesvirus infection make the development of new therapeutic agents a challenge. Currently used nucleoside analogues exhibit few side effects and have low occurrence of clinically relevant resistance. For HCMV, however, existing drugs have significant toxicity issues and the frequency of drug resistance is high, and no antiviral therapies are available for EBV and KSHV. The development of new anti-herpesvirus drugs is thus well worth pursuing especially for immunocompromised patients and those who develop drug-resistant infections. Although the HPIs are promising, limitations to their development into a successful drug strategy remain.
Electro-optic modulation of optical guided wave in LiNbO3 thin film fabricated by EGM method (1974)

Experiments on light propagation and electro-optic modulation have been made for poled LiNbO3 single-crystal thin films fabricated by the method of epitaxial growth by melting (EGM). The values of the refractive indices are found to be no = 2.200 and ne = 2.184. A phase modulation experiment has been carried out using a Mach-Zehnder interferometer in the region of 100 Hz-3 MHz. The electro-optic coefficients of the film have been determined by the phase-compensation method, and the values obtained are r33=12 and r13=2.3×10−12 m/V.
Cosy: develop in user-land, run in kernel-mode (2003)

User applications that move a lot of data across the user-kernel boundary suffer from a serious performance penalty. We provide a framework, Compound System Calls (Cosy), to enhance the performance of such userlevel applications. Cosy provides a user-friendly mechanism to execute the data-intensive code segment of the application in the kernel. This is achieved by aggregating the data-intensive system calls and the intermediate code into a compound. This compound is executed in the kernel, avoiding redundant data copies. A Cosy version of GCC makes the formation of a Cosy compound simple. Cosy-GCC automatically converts user-defined code segments into compounds. To ensure the security of the kernel, we use a combination of static and dynamic checks. We limit the execution time of the application in the kernel by using a modified preemptible kernel. Kernel data integrity is assured by performing necessary dynamic checks. Static checks are enforced by Cosy-GCC. To study the performance benefits of our Cosy prototype, we instrumented applications such asgrep andls. These application showed an improvement of 20–80%. Our current work focuses on faster and secure execution of entire programs in the kernel without source code modification. 1
Wetland Arid Vegetation – Studies of Vegetated Stormwater Management System Performance in Northern Utah – Field & Lab Experiences (2019)

Motivation for the Work We’ve Done – The Why Summary of the Work We’ve Done - The What & The How Findings - The How Well Conclusions & Recommendations – The So What
Polycapillary optics based neutron focusing for small sample neutron crystallography. (2002)

This work presents preliminary measurements designed to explore a new approach to neutron diffraction that is somewhat analogous to the pseudo-Laue technique, except that instead of using a broad energy (wavelength) bandwidth it uses a broad angular bandwidth. We have used a polycapillary focusing optic to focus neutrons from a monochromatic beam (using the BT-8 spectrometer on the NIST research reactor) and from a polychromatic beam at a pulsed spallation source (the Intense Pulsed Neutron Source, IPNS at Argonne National Laboratory) into a small, intense spot and have carried out preliminary diffraction measurements. Using the single crystal diffraction (SCD) facility on IPNS, diffraction of a 3{sup o} convergent beam from an alpha quartz crystal showed six diffraction beams in the 1-5{angstrom} wavelength bandwidth transmitted by the optic. The diffraction spots showed an intensity gain of 5.8 {+-} 0.9 compared to a direct beam diffracting from the same sample volume as that illuminated by the convergent beam.
Unsupervised-Learning-Based Feature-Level Fusion Method for Mura Defect Recognition (2017)

Mura defect recognition has long been a challenging task in displays, such as the liquid-crystal display (LCD), organic light-emitting diode display and polymer light-emitting diode display. In this paper, we propose an unsupervised-learning-based feature-level fusion approach for mura defect recognition. The approach is known as a joint-feature-representation-based defect recognition framework method. This method concentrates on obtaining effective and sufficient features for mura defects by fusing handcrafted and unsupervised-learned features in a complementary manner. To demonstrate the performance, several experiments are carried out to compare this method with some widely used feature extraction approaches. Experimental results show that the proposed method is more robust and accurate. They also indicate that it is compatible with different unsupervised-learning-based algorithms and handcrafted feature descriptors. Finally, the proposed method is implemented in the vision inspection equipment for recognizing mura defects in thin-film-transistor-LCD panels. It exhibits high robustness and improves the recognition performance by nearly 20% compared with the traditional handcrafted feature descriptors.
On the complexity of the Extended String-to-String Correction Problem (1975)

The Extended String-to-String Correction Problem [ESSCP] is defined as the problem of determining, for given strings A and B over alphabet V, a minimum-cost sequence S of edit operations such that S(A) = B. The sequence S may make use of the operations: Change, Insert, Delete and Swaps, each of constant cost WC, WI, WD, and WS respectively. Swap permits any pair of adjacent characters to be interchanged. The principal results of this paper are: (1) a brief presentation of an algorithm (the CELLAR algorithm) which solves ESSCP in time O(¦A¦* ¦B¦* ¦V¦s*s), where s = min(4WC, WI+WD)/WS + 1; (2) presentation of polynomial time algorithms for the cases (a) WS = 0, (b) WS > 0, WC= WI= WD=
Préhistoriens et paléontologues (1997)

La présence de disciplines consacrées aux origines de l'Homme, et non à la société éthiopienne ou à ses racines les plus directes, dans une présentation des études éthiopiennes en France pourrait paraître hors de propos si ces disciplines n'avaient pas indirectement joué aussi leur rôle dans le développement des sciences sociales. Même si l'histoire des origines de l'Homme dépasse largement celle des frontières qui, hier ou aujourd'hui, déterminent peu ou prou le domaine de nos recherches en ...
Amatoxins and phallotoxins in Amanita species of the northeastern United States. (1977)

The amatoxin and phallotoxin content of some American specimens of green A. phalloides and white A. bisporigera, A. verna and A. virosa was determined. The analytical procedure consisted of extracting the toxins from dried mushroom tissue, defatting, fractionating the toxins by adsorption chromatography on Sephadex LH-20, desalting and running thin-layer chromatograms of appropriate fractions along with authentic toxin samples. One amatoxin, amanin, was identified by hydrolysis to its components amino acids. Except for some difference in relative amounts of toxins, American and European varieties of A. phalloides were quite similar. Neither phallotoxins nor amatoxins were present in three out of four collections of A. verna; the fourth contained only a trace of beta-amanitin. Amanin was the sole of amatoxin present in two out of four collections of A. virosa; alpha-amanitin was the chief amatoxin in the other two. None of the white Amanita species contained phallacidin. The taxonomy of the above species is discussed. A literature report that edible A. rubescens contains phallotixins was not confirmed.