gebhart/patrepeval huggingface dataset:
Enhanced Surface Activity of MWW Zeolite Nanosheets Prepared via a One-Step Synthesis (2020)

The synthesis of two-dimensional (2D) zeolites has garnered attention due to their superior properties for applications that span catalysis to selective separations. Prior studies of 2D zeolite catalysts demonstrated enhanced mass transport for improved catalyst lifetime and selectivity. Moreover, the significantly higher external surface area of 2D materials allows for reactions of bulky molecules too large to access interior pores. There are relatively few protocols for preparing 2D materials, owing to the difficultly of capping growth in one direction to only a few unit cells. To accomplish this, it is often necessary to employ complex, commercially unavailable organic structure-directing agents (OSDAs) prepared <i>via</i> multistep synthesis. However, a small subset of zeolite structures exist as naturally layered materials where postsynthesis steps can be used to exfoliate samples and produce ultrathin 2D nanosheets. In this study, we selected a common layered zeolite, the MWW framework, to explore methods of preparing 2D nanosheets <i>via</i> one-pot synthesis in the absence of complex organic templates. Using a combination of high-resolution microscopy and spectroscopy, we show that 2D MMW-type layers with an average thickness of 3.5 nm (ca. 1.5 unit cells) can be generated using the surfactant cetyltrimethylammonium (CTA), which operates as a dual OSDA and exfoliating agent to affect Al siting and to eliminate the need for postsynthesis exfoliation, respectively. We tested these 2D catalysts using a model reaction that assesses external (surface) Brønsted acid sites and observed a marked increase in the conversion relative to three-dimensional MWW (MCM-22) and 2D layers prepared from postsynthesis exfoliation (ITQ-2). Collectively, our findings identify a facile and effective route to directly synthesize 2D MWW-type materials, which may prove to be more broadly applicable to other layered zeolites.
Recombinant Human Thrombopoietin in Combination With Granulocyte Colony-Stimulating Factor Enhances Mobilization of Peripheral Blood Progenitor Cells, Increases Peripheral Blood Platelet Concentration, and Accelerates Hematopoietic Recovery Following High-Dose Chemotherapy (1999)

Lineage-specific growth factors mobilize peripheral blood progenitor cells (PBPC) and accelerate hematopoietic recovery after high-dose chemotherapy. Recombinant human thrombopoietin (rhTPO) may further increase the progenitor-cell content and regenerating potential of PBPC products. We evaluated the safety and activity of rhTPO as a PBPC mobilizer in combination with granulocyte colony-stimulating factor (G-CSF) in 29 breast cancer patients treated with high-dose chemotherapy followed by PBPC reinfusion. Initially, patients received escalating single doses of rhTPO intravenously (IV) at 0.6, 1.2, or 2.4 μg/kg, on day 1. Subsequent patients received rhTPO 0.6 or 0.3 μg/kg on days −3, −1, and 1, or 0.6 μg/kg on days −1 and 1. G-CSF, 5 μg/kg IV or subcutaneously (SC) twice daily, was started on day 3 and continued through aphereses. Twenty comparable, concurrently and identically treated patients (who were eligible and would have been treated on protocol but for the lack of study opening) mobilized with G-CSF alone served as comparisons. CD34+ cell yields were substantially higher with the first apheresis following rhTPO and G-CSF versus G-CSF alone: 4.1 × 106/kg (range, 1.3 to 17.6) versus 0.8 × 106/ kg (range, 0.3 to 4.2), P = .0003. The targeted minimum yield of 3 × 106CD34+ cells/kg was procured following a single apheresis procedure in 61% of the rhTPO and G-CSF–mobilized group versus 10% of G-CSF–mobilized patients (P = .001). In rhTPO and G-CSF mobilized patients, granulocyte (day 8 v 9, P= .0001) and platelet recovery (day 9 v 10, P= .07) were accelerated, and fewer erythrocyte (3 v 4,P = .02) and platelet (4 v 5, P = .02) transfusions were needed compared with G-CSF–mobilized patients. Peripheral blood platelet counts, following rhTPO and G-CSF, were increased by greater than 100% and the platelet content of PBPC products by 60% to 110% on the first and second days of aphereses (P < .0001) with the greatest effect seen with repeated dosing of rhTPO at 0.6 μg/kg. rhTPO is safe and well tolerated as a mobilizing agent before PBPC collection. Mobilization with rhTPO and G-CSF, in comparison to a comparable, nonrandomized G-CSF–mobilized group of patients, decreases the number of apheresis procedures required, may accelerate hematopoietic recovery, and may reduce the number of transfusions required following high-dose chemotherapy for breast cancer.
Mechanism of lethal action of 2,450-MHz radiation on microorganisms (1979)

Various bacteria, actinomycetes, fungi, and bacteriophages were exposed to microwaves of 2,450 +/- 20 MHz in the presence and in the absence of water. It was found that microorganisms were inactivated only when in the presence of water and that dry or lyophilized organisms were not affected even by extended exposures. The data presented here prove that microorganisms are killed by "thermal effect" only and that, most likely, there is no "nonthermal effect"; cell constituents other than water do not absorb sufficient energy to kill microbial cells.
Does Chemistry Really Matter in the Chemical Vapor Deposition of Titanium Dioxide? Precursor and Kinetic Effects on the Microstructure of Polycrystalline Films (1999)

A side-by-side comparison of the TiO2 deposition kinetics and the corresponding microstructures was studied. The two precursors were titanium(IV) isopropoxide and anhydrous titanium(IV) nitrate, and all depositions were conducted at low pressures (<10-4 Torr) in an ultrahigh vacuum chemical vapor deposition reactor. For both precursors deposition kinetics were qualitatively similar and exhibited three distinct regimes as a function of temperature. At the lowest temperatures, growth was limited by the rate of precursor reaction on the substrate surface. At intermediate temperatures flux-limited growth was obtained, and at the highest temperatures the growth rates decreased with increasing temperatures. The overall behavior was modeled quantitatively for each precursor using a two-step mechanism involving reversible adsorption followed by irreversible reaction. Titanium(IV) nitrate exhibited a lower activation energy of reaction (Er = 98 kJ/mol) which allowed deposition at lower temperatures compared to titanium(IV) isopropoxide (Er = 135 kJ/mol). The film microstructures were examined using transmission and scanning electron microscopy and X-ray diffraction. Comparison of the microstructures of films deposited at similar temperatures revealed significant differences in the reaction rate-limited regime. As the growth rates of the two precursors converged in the flux-limited regime, the respective microstructures became indistinguishable. The importance of precursor surface coverage and diffusion on this effect is described.
[3 + 2] Cycloaddition of Acetylenes with Azides to Give 1,4‐Disubstituted 1,2,3‐Triazoles in a Modular Flow Reactor. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Replacing Error Vector Magnitude Test with RF and Analog BISTs (2011)

RF and analog BIST techniques are capable of replacing the traditional error vector magnitude (EVM) test used in production. In a case study, four BISTs detected actual production faults in a commercial, highly integrated WLAN device. In combination with traditional digital testing, the BISTs caught an impressive 100% of EVM failures during production of over a million devices, which presents significant opportunities for both cost and time savings.
L'esperimento Dalton di "ultra cheap money" (2017)

JEL
Formation and molecular structures of (.eta.5-pentabenzylcyclopentadienyl)- and (.eta.5-pentaphenylcyclopentadienyl)dicarbonyl derivatives of cobalt and rhodium (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation and molecular structures of (.eta.5-pentabenzylcyclopentadienyl)- and (.eta.5-pentaphenylcyclopentadienyl)dicarbonyl derivatives of cobalt and rhodiumJohn W. Chambers, Andrew J. Baskar, Simon G. Bott, Jerry L. Atwood, and Marvin D. RauschCite this: Organometallics 1986, 5, 8, 1635–1641Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/om00139a020https://doi.org/10.1021/om00139a020research-articleACS PublicationsRequest reuse permissionsArticle Views860Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Purification and Partial Characterization of a Prolyl-Dipeptidyl Aminopeptidase from <i>Lactobacillus helveticus</i> CNRZ 32 (1990)

X-prolyl-dipeptidyl aminopeptidase, which hydrolyzed Gly-Pro-p-nitroanilide (relative activity [RA] = 100%) and Arg-Pro-p-nitroanilide (RA, 130%), was purified to homogeneity from the cell extract of Lactobacillus helveticus CNRZ 32. The enzyme also hydrolyzed Ala-Pro-Gly (RA, 11%) and Ala-Ala-p-nitroanilide (RA, 2%) but was not active on Ala-Leu-Ala, dipeptides, and endopeptidase and carboxypeptidase substrates. The enzyme was purified 145-fold by streptomycin sulfate precipitation, ammonium sulfate fractionation, and a series of column chromatographies on DEAE-cellulose, arginine-Sepharose 4B, and glycyl-prolyl-AH-Sepharose 4B. The purified enzyme appeared as a single band on native polyacrylamide gel and sodium dodecyl sulfate-polyacrylamide gel electrophoreses and had a molecular weight of 72,000. Optima for activity by the purified enzyme were pH 7.0 and 40 degrees C. The enzyme was incubated at 40 degrees C for 15 min with various metal ions. It was activated by Mg (2.5 mM), Ca (0.1 to 2.5 mM), Na (10 to 50 mM), and K (10 to 50 mM) and was inhibited by Hg (0.1 to 2.5 mM), Cu (0.1 to 2.5 mM), and Zn (0.1 to 2.5 mM). Enzyme activity was partially inhibited by EDTA (1.0 mM, 20 h at 40 degrees C), 1,10-phenanthroline (1.0 mM, 15 min at 40 degrees C), phenylmethylsulfonyl fluoride (1.0 mM), N-ethylmaleimide (1.0 mM), and iodoacetate (1.0 mM). It was completely inhibited by diisopropyl fluorophosphate (1.0 mM, 2 h at 40 degrees C) and p-chloromercuribenzoate (1.0 mM, 15 min at 40 degrees C). The enzyme was not affected by dithioerythritol (1.0 to 10 mM).
Activating <i>NOTCH1</i> Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors (2017)

Purpose Adenoid cystic carcinomas (ACCs) represent a heterogeneous group of chemotherapy refractory tumors, with a subset demonstrating an aggressive phenotype. We investigated the molecular underpinnings of this phenotype and assessed the Notch1 pathway as a potential therapeutic target. Methods We genotyped 102 ACCs that had available pathologic and clinical data. Notch1 activation was assessed by immunohistochemistry for Notch1 intracellular domain. Luciferase reporter assays were used to confirm Notch1 target gene expression in vitro. The Notch1 inhibitor brontictuzumab was tested in patient-derived xenografts from patients with ACC and in a patient with ACC who was enrolled in a phase I study. Results NOTCH1 mutations occurred predominantly (14 of 15 patients) in the negative regulatory region and Pro-Glu-Ser-Thr-rich domains, the same two hotspots seen in T-cell acute lymphoblastic leukemias, and led to pathway activation in vitro. NOTCH1-mutant tumors demonstrated significantly higher levels of Notch1 pathway activation than wild-type tumors on the basis of Notch1 intracellular domain staining ( P = .004). NOTCH1 mutations define a distinct aggressive ACC subgroup with a significantly higher likelihood of solid subtype ( P < .001), advanced-stage disease at diagnosis ( P = .02), higher rate of liver and bone metastasis ( P ≤ .02), shorter relapse-free survival (median, 13 v 34 months; P = .01), and shorter overall survival (median 30 v 122 months; P = .001) when compared with NOTCH1 wild-type tumors. Significant tumor growth inhibition with brontictuzumab was observed exclusively in the ACC patient-derived xenograft model that harbored a NOTCH1 activating mutation. Furthermore, an index patient with NOTCH1-mutant ACC had a partial response to brontictuzumab. Conclusion NOTCH1 mutations define a distinct disease phenotype characterized by solid histology, liver and bone metastasis, poor prognosis, and potential responsiveness to Notch1 inhibitors. Clinical studies targeting Notch1 in a genotype-defined ACC subgroup are warranted.
Flow Cytofluorometric Analysis in Red Blood Cell Immunology (2004)

Flow cytofluorometry (FC) is primarily used in the clinical laboratory for the analysis of white blood cells but also has applications in the study of red blood cell (RBC) immunology. When studying RBCs by FC it is important to avoid agglutination of the RBCs, which ironically is the endpoint for most immunohematologic assays. When studying low levels of RBC-bound antibody or RBC antigens with low copy number, background noise due to autofluorescence and nonspecific binding need to be taken into account. It is also important to ensure that reagents (e.g. antisera) used by FC have been standardized for use by FC. Applications of FC in RBC immunology include i) detection and quantitation of globulin (RBC-bound or free in serum), ii) detection and quantitation of RBC antigens, and iii) detection and quantitation of mixed cell populations. FC can be used to differentiate the amount of IgG on strongly IgG-coated RBCs, as well as to detect small amounts of RBC-bound IgG. FC has been used to quantitate antibody that is free in serum, e.g. anti-D in a pregnant woman or in immune globulin preparations. Many RBC antigens have been studied by FC to determine the number of antigen sites, the density distribution, and phenotype-related differences (e.g. zygosity). FC has been found to be very useful for studying mixed cell populations; applications include fetomaternal hemorrhage quantitation, determination of survival/ clearance of transfused RBCs, phenotyping of transfused patients’ RBCs, evaluation of bone marrow transplant engraftment, and study of RBC chimerism and mosaicism.
Inactivation of Alpha-Amylase in Wheat Flour with Microwaves<sup>*</sup> (1972)

High alpha-amylase flour was exposed to microwave energy in a 1.8 KW 2450 MHz oven for periods ranging from 30 to 100 sec. The effect of the exposure on the enzyme activity was studied. The influence of the different exposures on the moisture content of the flour, its bacterial counts as well as its dough-development and the gassing power of the dough was determined.The 60-sec exposure of the flour to microwave energy reduced the enzyme activity to an acceptable level without any deleterious effects on the principal characteristics of the flour related to dough formation. This exposure drastically reduced the number of viable organisms in the flour, but seemed to cause a somewhat high loss in moisture.
Platinum binding to DNA: structural controls and consequences (2001)

In recent years there have been numerous major advances in the understanding of the factors controlling all aspects of platinum binding to DNA and of the consequences of DNA binding. The interaction with DNA involves numerous stages, including: aquation of the complex, preassociation with the DNA, monofunctional adduct formation, closure to a bifunctional adduct, distortion of the DNA and recognition of this distortion. In this review we outline how the recent advances have increased our understanding of the factors controlling each of these steps and the implications for rational drug development.
Effect of milling process on the magnetic properties of FIB patterned magnetic nanostructures (2003)

Summary form only given. There has been much interest in nano-patterning of hard and soft magnetic materials and perpendicular recording media using the FIB technique, but very few of them has been focused on the milling process and its effect on the magnetic properties of the patterned nanostructures. In this work, the FIB patterning of commercial post-sputtering longitudinal media has been performed with emphasis on how the redeposition would affect the morphology of the patterned structure as well as its magnetic properties. The former was studied using AFM and the latter by MFM.
Automated wafer transport in the wafer Fab (2002)

Through simulations with models, HP's Inkjet Supplies Business Unit has determined that intrabay material transport with automated delivery of wafers directly to process tools substantially increases the throughput of our semiconductor manufacturing facility (Fab). To fully utilize limited Fab space, an architecture using overhead track and vehicles has been selected. HP cooperated with a Supplier of automated material handling systems (AMHS) to develop this "zero footprint" solution. The experiences learned from a first-generation prototype system have been incorporated into a second generation prototype, which is currently being characterized at HP's Corvallis site. Due to the long AMHS development cycle, the new Corvallis Fab started its operation with manual material transport, using SMIF pods as carrying containers. All process tools have been equipped with SMIF (Standard Mechanical Interface) load ports. Applying AEC (Automated Equipment Control) station controllers manage lot identification, WIP tracking and recipe selection. The SMIF industry standard for load port design, and AEC have proven to be valuable enablers to achieve AMHS with automated pod delivery and pick-up to and from process tools.
Effects of Prostanoids on the Rat’s Myometrium in Vitro during Pregnancy1 (1992)

The objectives of this study were to determine the effects of pregnancy in the rat on the contractile response of the myometrium in vitro to a number of prostanoids. Longitudinally and circularly oriented strips were studied separately. Responses to PG (prostaglandin)F2 alpha, PDG2, the PGI2-mimetic iloprost, and the thromboxane (Tx) A2-mimetic U-46619 were investigated on Days 10, 15, 18, 20, 21, and 22 of pregnancy. Responses were prostanoid-dependent, and differences between longitudinal and circular strips were small. PGF2 alpha and PGD2 produced similar patterns, with a high potency but low maximal response on Day 10; thereafter potency fell to a minimum value on Day 18 and then gradually increased until Day 22, when it was still lower than at Day 10. In contrast, for PGE2 there were no changes in potency over the period of study (longitudinal muscle) or a slight increase between Days 15 and 21 (circular muscle). Both iloprost and U-46619 maintained a low potency throughout pregnancy. We conclude that the pregnant rat's myometrium is probably not a target for PGI2 or TxA2 and that the difference patterns of responses to PGE2 and PGF2 alpha during pregnancy support the hypotheses that these prostanoids act at different sites within the myometrium.
miR-17-5p Regulates Endocytic Trafficking through Targeting TBC1D2/Armus (2012)

miRNA cluster miR-17-92 is known as oncomir-1 due to its potent oncogenic function. miR-17-92 is a polycistronic cluster that encodes 6 miRNAs, and can both facilitate and inhibit cell proliferation. Known targets of miRNAs encoded by this cluster are largely regulators of cell cycle progression and apoptosis. Here, we show that miRNAs encoded by this cluster and sharing the seed sequence of miR-17 exert their influence on one of the most essential cellular processes - endocytic trafficking. By mRNA expression analysis we identified that regulation of endocytic trafficking by miR-17 can potentially be achieved by targeting of a number of trafficking regulators. We have thoroughly validated TBC1D2/Armus, a GAP of Rab7 GTPase, as a novel target of miR-17. Our study reveals regulation of endocytic trafficking as a novel function of miR-17, which might act cooperatively with other functions of miR-17 and related miRNAs in health and disease.
Antibiotic Properties and Applications of Lactoferrin (2007)

Lactoferrin (Lf), a mammalian iron scavenging defense protein, constitutively is present in exocrine secretions that consistently are exposed to microbial flora: milk, tears, tubotympanum and nasal exudate, saliva, bronchial mucus, gastrointestinal fluids, cervicovaginal mucus, and seminal fluid. Additionally, Lf is promptly delivered by circulating neutrophils to sites of microbial invasion. At these sites, the protein effectively scavenges iron at pH values as low as 3.5. Recombinant bovine and human lactoferrin is now available for development into nutraceutical/preservative/pharma- ceutical products. Among conditions for which the products are being investigated are: angiogenesis; bone remodeling; food preservation; infection in animals, humans, plants; neoplasia in animals, humans; inflammation in intestine, joints; wound healing; as well as enhancement of antimicrobial and antineoplastic drugs, and prevention of iron induced oxidation of milk formula. Keywords: Bone remodeling, chelation, infection, iron, lactoferrin, lysozome, neoplasia, wound healing
Hash Functions for Episodic Recognition and Retrieval (2016)

Episodic memory systems for artificially intelligent agents must copewith an ever-growing episodic memory store. This paper presents an approach for minimizing the size of the store by using specialized hash functions to convert each memory into a relatively short binary code. A set of desiderata for such hash functions are presented including locale sensitivity and reversibility. The paper then introduces multiple approaches for such functions and compares their effectiveness.
Development of a parallel local oxidation nanolithography instrument (2006)

We have developed an instrument to perform local oxidation nanofabrication processes in parallel. The instrument has three major components, the stamp holder, the sample base, and the supporting frame. The sample base is actuated by three precision screws that enable motion in the three orthogonal directions. Sample base and stamp holder are enclosed and sealed inside a chamber with two inlets to introduce different gases. The chamber is supported by a rigid frame. We show the parallel patterning of silicon oxide features on silicon surfaces by the application of a bias voltage between the sample and the stamp when they are in contact. Arrays of parallel lines separated by 100nm have been patterned over cm2 regions in one minute.