gebhart/patrepeval huggingface dataset:
Joe T Robinson: Always a Loyal Democrat (1999)

Joe T. Robinson: Always a Loyal Democrat. By Cecil Edward Weller Jr. (Fayetteville: University of Arkansas, 1998. Pp. xiv, 238. Acknowledgment, preface, illustrations, notes, bibliography, index. $38.00.) Cecil Edward Weller accomplishes his purpose in crafting a wellwritten, concise account of the public career of an Arkansan who flourished in the national political arena. Echoing the theme of Nevin E. Neal's 1958 dissertation, A Biography of Joseph T. Robinson, Weller asserts partisan loyalty guided Robinson's decisions. Weller's identification of Robinson with Arkansas Progressivism also follows influential studies by Joe Segraves and Richard Niswonger. Yet Weller's sketch of a life in politics obscures Robinson's personality and reduces the state's political currents to background static. Born in 1872, Robinson's toil on his family's farm near Lonoke stoked his drive for more genteel labor. Buoyed by an astute marriage and attachment to a powerful local patron, Robinson early made a reputation as a vitriolic defender of Democratic Party candidates against agrarian insurgents. First as a state legislator and then as a member of the U.S. House of Representatives, Robinson advocated business regulation, women's suffrage, and direct democracy procedures. In 1912 these stands and his renown as a stump speaker propelled his election as governor. Yet Robinson's Progressivism often wavered in the face of his monumental ambition. The champion of the popular election of U.S. senators brushed aside demands for a plebiscite upon the death of Sen. Jeff Davis and engineered his own ascension to the office. With the position secured, he again assumed the reform mantle. Before resigning as governor, Robinson deftly shepherded through the 1913 General Assembly the unfinished good government program of his predecessor, George W. Donaghey. The initial phase of Robinson's senatorial career coincided with the first Democratic presidential administration in sixteen years. Arkansas Democrats once again could count on their congressional delegation to deliver federal posts. Weller rightly emphasizes that Robinson's internationalism elevated him beyond a stolid patronage broker. If Robinson's support for the League of Nations ran deeper than mere allegiance to Woodrow Wilson, his opposition to a 1922 Republican arms limitation treaty suggested that even his own principles were subject to a party litmus test. Although a contender for the 1924 Democratic presidential nomination and tabbed as Al Smith's running mate for the 1928 contest, Robinson achieved his political apogee as senate majority leader during Franklin Roosevelt's tenure. Weller's exhaustive and impressively researched descriptions of Robinson's stewardship of New Deal legislation substantiates the Arkansan's reputation as one of the twentieth-century's most notable congressional leaders. …
Application Of A Prediction And Smoothing Algorithm To Non-invasive blood Pressure Measurement (2005)

This paper presents an approach to the problem of artifact sensitivity in non-invasive-blood-pressure (NIBP) measurement using the oscillometric technique. An algorithm based on the Kalman filter with fixed lag smoothing was employed to predict the next oscillometric pulse amplitude and cuff pressure and to generate a smooth 'curve from which the patient's blood pressure is computed. The algorithm has been implemented in a transport vital signs monitor. Clinical testing has demonstrated that the accuracy of the blood pressure measurements are well within AAMI specifications. Use in patient environments, including ambulance and helicopter transport, has demonstrated that the system is very robust in the presence of patient motion.
Plasmid Construction Using Recombination Activity in the Fission Yeast Schizosaccharomyces pombe (2010)

We concluded that GRC was sufficiently feasible in S. pombe for genome-wide gene functional analysis as well as for regular plasmid construction. Plasmids with different markers constructed in this research are available from NBRP-yeast (http://yeast.lab.nig.ac.jp/).
Galectin-3 Translocates to the Perinuclear Membranes and Inhibits Cytochrome c Release from the Mitochondria (2002)

Galectin-3 is a multifunctional oncogenic protein found in the nucleus and cytoplasm and also the extracellular milieu. Although recent studies demonstrated an anti-apoptotic activity of galectin-3, neither the functional site nor the mechanism of how galectin-3 regulates apoptosis is known. In this study, we examined the subcellular localization of galectin-3 during apoptosis and investigated its anti-apoptotic actions. We report that galectin-3 translocates to the perinuclear membrane following a variety of apoptotic stimuli. Confocal microscopy and biochemical analysis revealed that galectin-3 is enriched in the mitochondria and prevents mitochondrial damage and cytochrome c release. Using a yeast two-hybrid system, we screened for galectin-3-interacting proteins that regulate galectin-3 localization and anti-apoptotic activity. Synexin, a Ca(2+)- and phospholipid-binding protein, was one of the proteins identified. We confirmed direct interaction between galectin-3 and synexin by glutathione S-transferase pull-down assay in vitro. We showed that galectin-3 failed to translocate to the perinuclear membranes when expression of synexin was down-regulated using an oligodeoxyribonucleotide complementary to the synexin mRNA, suggesting a role for synexin in galectin-3 trafficking. Furthermore, synexin down-regulation abolished anti-apoptotic activity of galectin-3. Taken together, these results suggest that synexin mediates galectin-3 translocation to the perinuclear mitochondrial membranes, where it regulates mitochondrial integrity critical for apoptosis regulation.
Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin. (1993)

The murine allele temperature-sensitive (ts) p53Val-135 encodes a ts p53 protein that behaves as a mutant polypeptide at 37 degrees C and as a wild-type polypeptide at 32 degrees C. This ts allele was introduced into the p53 nonproducer Friend erythroleukemia cell line DP16-1. The DP16-1 cell line was derived from the spleen cells of a mouse infected with the polycythemia strain of Friend virus, and like other erythroleukemia cell lines transformed by this virus, it grows independently of erythropoietin, likely because of expression of the viral gp55 protein which binds to and activates the erythropoietin receptor. When incubated at 32 degrees C, DP16-1 cells expressing ts p53Val-135 protein, arrested in the G0/G1 phase of the cell cycle, rapidly lost viability and expressed hemoglobin, a marker of erythroid differentiation. Erythropoietin had a striking effect on p53Val-135-expressing cells at 32 degrees C by prolonging their survival and diminishing the extent of hemoglobin production. This response to erythropoietin was not accompanied by down-regulation of viral gp55 protein.
Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer (2017)

<b>Purpose:</b> Patients with metastatic colorectal cancer suffer from disease relapse mainly due to cancer stem cells (CSC). Interestingly, they have an increased level of blood progastrin, a tumor-promoting peptide essential for the self-renewal of colon CSCs, which is also a direct β-catenin/TCF4 target gene. In this study, we aimed to develop a novel targeted therapy to neutralize secreted progastrin to inhibit Wnt signaling, CSCs, and reduce relapses.<b>Experimental Design:</b> Antibodies (monoclonal and humanized) directed against progastrin were produced and selected for target specificity and affinity. After validation of their effectiveness on survival of colorectal cancer cell lines harboring B-RAF or K-RAS mutations, their efficacy was assessed <i>in vitro</i> and <i>in vivo</i>, alone or concomitantly with chemotherapy, on CSC self-renewal capacity, tumor recurrence, and Wnt signaling.<b>Results:</b> We show that anti-progastrin antibodies decrease self-renewal of CSCs both <i>in vitro</i> and <i>in vivo</i>, either alone or in combination with chemotherapy. Furthermore, migration and invasion of colorectal cancer cells are diminished; chemosensitivity is prolonged in SW620 and HT29 cells and posttreatment relapse is significantly delayed in T84 cells, xenografted nude mice. Finally, we show that the Wnt signaling activity <i>in vitro</i> is decreased, and, in transgenic mice developing Wnt-driven intestinal neoplasia, the tumor burden is alleviated, with an amplification of cell differentiation in the remaining tumors.<b>Conclusions:</b> Altogether, these data show that humanized anti-progastrin antibodies might represent a potential new treatment for K-RAS-mutated colorectal patients, for which there is a crucial unmet medical need. <i>Clin Cancer Res; 23(17); 5267-80. ©2017 AACR</i>.
Isonitrile, XVIII. Hydantoin‐imide‐(4) (1964)

Abstract Aldehyde oder Ketone und primäre Amine sowie die daraus erhältlichen SCHIFFschen Basen reagieren mit Isonitrilen und Cyansäure unter Bildung von Hydantoin‐imiden‐(4) (IV a–x).
Localization and Tracking in Sensor Systems (2006)

In this paper, we survey the current state-of-art of localization and tracking. Our emphasis is on algorithms and systems used in sensor networks. We categorize localization and tracking systems into a hierarchical taxonomy based on characteristics of the objects being tracked, the application environments, and the sensor network technologies. Ideas leading to new directions for future research are briefly discussed.
6-Bromoindirubin-3′-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells (2011)

STAT3 is persistently activated and contributes to malignant progression in various cancers. Janus activated kinases (JAK) phosphorylate STAT3 in response to stimulation by cytokines or growth factors. The STAT3 signaling pathway has been validated as a promising target for development of anticancer therapeutics. Small-molecule inhibitors of JAK/STAT3 signaling represent potential molecular-targeted cancer therapeutic agents. In this study, we investigated the role of JAK/STAT3 signaling in 6-bromoindirubin-3'-oxime (6BIO)-mediated growth inhibition of human melanoma cells and assessed 6BIO as a potential anticancer drug candidate. We found that 6BIO is a pan-JAK inhibitor that induces apoptosis of human melanoma cells. 6BIO directly inhibited JAK-family kinase activity, both in vitro and in cancer cells. Apoptosis of human melanoma cells induced by 6BIO was associated with reduced phosphorylation of JAKs and STAT3 in both dose- and time-dependent manners. Consistent with inhibition of STAT3 signaling, expression of the antiapoptotic protein Mcl-1 was downregulated. In contrast to the decreased levels of phosphorylation of JAKs and STAT3, phosphorylation levels of the Akt and mitogen-activated protein kinase (MAPK) signaling proteins were not inhibited in cells treated with 6BIO. Importantly, 6BIO suppressed tumor growth in vivo with low toxicity in a mouse xenograft model of melanoma. Taken together, these results show that 6BIO is a novel pan-JAK inhibitor that can selectively inhibit STAT3 signaling and induces tumor cell apoptosis. Our findings support further development of 6BIO as a potential anticancer therapeutic agent that targets JAK/STAT3 signaling in tumor cells.
ChemInform Abstract: Palladium‐Catalyzed Stille Coupling for the Preparation of Ferrocenyl Thiophene Derivatives. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Characterization of InP Grown by OMVPE Using Tertiary-butylphosphine for the Phosphorous Source (1990)

InP layers were grown by organometallic vapor phase epitaxy (OMVPE) at atmospheric pressure using trimethylindium (TMI) and tertiarybutylphosphine (TBP) as source gases. Specular surfaces were obtained at growth temperatures between 550°C and 600°C and at the V/III ratio of 79. Electrical and optical characterizations were carried out to elucidate the behavior of unintentionally doped impurities in the grown layers. All the epitaxial layers showed n-type conductivity. The highest electron Hall mobilities were 3800 cm 2 V -1 s -1 at 300 K and 12000 cm 2 V -1 s -1 at 77 K with the electron concentrations of 7.5×10 15 cm -3 and 6.8×10 15 cm -3 , respectively. Possible impurity sources were discussed.
Parallel Algorithmic Techniques For CombinationalComputation (1988)

We have described a number of algorithmic tools that have been found useful in the construction of parallel algorithms; among these are prefix computation, ranking, Euler tours, ear decomposition, and matrix calculations. We have also described some of the applications of these tools, and listed many other applications. These algorithms seem likely to be useful not only in their own right, but also as examples of ways to break up other problems into parts suitable for parallel solution.
[Effects of longterm selection on the genetic structure of populations--a simulation study. I. Simulation models and selection responses]. (1989)

Monte Carlo method has been utilized to investigate responses to longterm selection. The simulation involves 3 gene effect models (additive, dominant, and over-dominant), two population sizes, three linkage intensities, and three heritability levels, thus making 54 combinations. For each combination, 5 replicate populations are selected over 49 consecutive non-overlapping generations. The results demonstrate that under all the gene effect models, linkage is important only in the case of small populations and intense linkage, when it reduces responses significantly due to hampering the fixation of favourable alleles and accelerating their loss. Linkage has no apparent effect if it is not very tight or if the population is large. Much greater responses are achieved in the large populations than in the small ones, especially for traits with low heritability. Among those discussed are problems of crossing selected lines to obtain extra responses, and discrepancy of some theoretic results on selection limits.
Flexible and Stretchable Electronics Paving the Way for Soft Robotics (2013)

Abstract Planar and rigid wafer-based electronics are intrinsically incompatible with curvilinear and deformable organisms. Recent development of organic and inorganic flexible and stretchable electronics enabled sensing, stimulation, and actuation of/for soft biological and artificial entities. This review summarizes the enabling technologies of soft sensors and actuators, as well as power sources based on flexible and stretchable electronics. Examples include artificial electronic skins, wearable biosensors and stimulators, electronics-enabled programmable soft actuators, and mechanically compliant power sources. Their potential applications in soft robotics are illustrated in the framework of a five-step human–robot interaction loop. Outlooks of future directions and challenges are provided at the end.
Context-awareness: some compelling applications (2000)

It is claimed that, to become credible in the marketplace, context-awareness needs a killer application. Killer applications are rare in most fields, but we believe that there are context-aware applications that can at least merit the adjective ‘compelling’. We present a list of six types of context-aware application that we think are either compelling now or soon will be. In order to present our list, we first discuss a key component of the necessary infrastructure: how context is captured and maintained.
Highly Efficient Chiral-Pool Synthesis of (2<i>S</i>,4<i>R</i>)-4-Hydroxyornithine (2001)

A concise synthesis of the amino acid (2S,4R)-4-hydroxyornithine is described. Starting from diprotected l-aspartic acid, the scaffold of the target compound is constructed in a three-step approach: an efficient α-nitroketone formation through acylation of nitromethane is followed by a diastereoselective reduction of the resulting ketone. In the last step, the nitro group is reduced to furnish the (2S,4R)-4-hydroxyornithine scaffold. This new approach to the title compound offers advantages to the synthetic pathways previously described.
Radiation Response of Neural Precursor Cells: Linking Cellular Sensitivity to Cell Cycle Checkpoints, Apoptosis and Oxidative Stress (2004)

Therapeutic irradiation of the brain can cause a progressive cognitive dysfunction that may involve defects in neurogenesis. In an effort to understand the mechanisms underlying radiation-induced stem cell dysfunction, neural precursor cells isolated from the adult rat hippocampus were analyzed for acute (0-24 h) and chronic (3-33 days) changes in apoptosis and reactive oxygen species (ROS) after exposure to X rays. Irradiated neural precursor cells exhibited an acute dose-dependent apoptosis accompanied by an increase in ROS that persisted over a 3-4-week period. The radiation effects included the activation of cell cycle checkpoints that were associated with increased Trp53 phosphorylation and Trp53 and p21 (Cdkn1a) protein levels. In vivo, neural precursor cells within the hippocampal dentate subgranular zone exhibited significant sensitivity to radiation. Proliferating precursor cells and their progeny (i.e. immature neurons) exhibited dose-dependent reductions in cell number. These reductions were less severe in Trp53-null mice, possibly due to the disruption of apoptosis. These data suggest that the apoptotic and ROS responses may be tied to Trp53-dependent regulation of cell cycle control and stress-activated pathways. The temporal coincidence between in vitro and in vivo measurements of apoptosis suggests that oxidative stress may provide a mechanistic explanation for radiation-induced inhibition of neurogenesis in the development of cognitive impairment.
An intelligent crowdsourcing system for forensic analysis of surveillance video (2015)

Video surveillance systems are of a great value for public safety. With an exponential increase in the number of cameras, videos obtained from surveillance systems are often archived for forensic purposes. Many automatic methods have been proposed to do video analytics such as anomaly detection and human activity recognition. However, such methods face significant challenges due to object occlusions, shadows and scene illumination changes. In recent years, crowdsourcing has become an effective tool that utilizes human intelligence to perform tasks that are challenging for machines. In this paper, we present an intelligent crowdsourcing system for forensic analysis of surveillance video that includes the video recorded as a part of search and rescue missions and large-scale investigation tasks. We describe a method to enhance crowdsourcing by incorporating human detection, re-identification and tracking. At the core of our system, we use a hierarchal pyramid model to distinguish the crowd members based on their ability, experience and performance record. Our proposed system operates in an autonomous fashion and produces a final output of the crowdsourcing analysis consisting of a set of video segments detailing the events of interest as one storyline.
Meta-analysis of randomised controlled trials of fluoxetine <i>v.</i> placebo and tricyclic antidepressants in the short-term treatment of major depression (2000)

Fluoxetine is superior to placebo, irrespective of the analytical approach use, whereas the results obtained v. TCAs depend on the approach used. Hence, the results should be interpreted in this light.
Detecting a single molecule using a micropore-nanopore hybrid chip (2013)

Nanopore-based DNA sequencing and biomolecule sensing have attracted more and more attention. In this work, novel sensing devices were built on the basis of the chips containing nanopore arrays in polycarbonate (PC) membranes and micropores in Si3N4 films. Using the integrated chips, the transmembrane ionic current induced by biomolecule's translocation was recorded and analyzed, which suggested that the detected current did not change linearly as commonly expected with increasing biomolecule concentration. On the other hand, detailed translocation information (such as translocation gesture) was also extracted from the discrete current blockages in basic current curves. These results indicated that the nanofluidic device based on the chips integrated by micropores and nanopores possessed comparative potentials in biomolecule sensing.
Femtosecond fiber chirped- and divided-pulse amplification system (2013)

We implement both chirped pulse amplification and divided pulse amplification in the same femtosecond fiber amplifier setup. This scheme allows an equivalent stretched pulse duration of 2.4 ns in a compact tabletop system. The generation of 77 W of compressed average power at 4.8 MHz, together with 320 fs and 430 μJ pulses at a repetition rate of 96 kHz, is demonstrated using a distributed mode-filtering, rod-type, ytterbium-doped fiber. Limitations in the temporal recombining efficiency due to gain saturation inside the fiber amplifier are identified.
Systemic Dysregulation of Angiopoietin-1 and -2 in Streptococcal Toxic Shock Syndrome (2011)

Streptococcal toxic shock syndrome (STSS) is characterized by diffuse vascular leak resulting from widespread endothelial activation. Angiopoietin-1 and -2 (Ang-1 and Ang-2), which are important regulators of endothelial quiescence and activation, respectively, are dysregulated in certain diseases that are associated with endothelial dysfunction, but they have not been previously investigated in STSS. Plasma Ang-1 and Ang-2 concentrations were measured in 37 patients with invasive streptococcal infection with and without concurrent STSS. Greater angiopoietin dysregulation (decreased Ang-1 and increased Ang-2) occurred in STSS than in invasive infection without shock; dysregulation decreased with convalescence. These results suggest that systemic Ang-1 and Ang-2 dysregulation is associated with disease severity in invasive streptococcal infection and that plasma levels of Ang-1 and Ang-2 may serve as clinically informative biomarkers in STSS.
Aeroacoustic Evaluation of Flap and Landing Gear Noise Reduction Concepts (2014)

Aeroacoustic measurements for a semi-span, 18% scale, high-fidelity Gulfstream aircraft model are presented. The model was used as a test bed to conduct detailed studies of flap and main landing gear noise sources and to determine the effectiveness of numerous noise mitigation concepts. Using a traversing microphone array in the flyover direction, an extensive set of acoustic data was obtained in the NASA Langley Research Center 14- by 22-Foot Subsonic Tunnel with the facility in the acoustically treated open-wall (jet) mode. Most of the information was acquired with the model in a landing configuration with the flap deflected 39 deg and the main landing gear alternately installed and removed. Data were obtained at Mach numbers of 0.16, 0.20, and 0.24 over directivity angles between 56 deg and 116 deg, with 90 deg representing the overhead direction. Measured acoustic spectra showed that several of the tested flap noise reduction concepts decrease the sound pressure levels by 2 - 4 dB over the entire frequency range at all directivity angles. Slightly lower levels of noise reduction from the main landing gear were obtained through the simultaneous application of various gear devices. Measured aerodynamic forces indicated that the tested gear/flap noise abatement technologies have a negligible impact on the aerodynamic performance of the aircraft model.