gebhart/patrepeval huggingface dataset:
COMP-Ang1 stimulates HIF-1α–mediated SDF-1 overexpression and recovers ischemic injury through BM-derived progenitor cell recruitment (2011)

Recruitment and adhesion of bone marrow (BM)-derived circulating progenitor cells to ischemic tissue are important for vasculogenesis and tissue repair. Recently, we found cartilage oligomeric matrix protein (COMP)-Ang1 is a useful cell-priming agent to improve the therapeutic efficacy of progenitor cells. However, the effect and the underlying mechanisms of COMP-Ang1 on recruitment of BM-derived progenitor cells (BMPCs) to foci of vascular injury have not been well defined. Here, we found that COMP-Ang1 is a critical stimulator of stromal cell-derived factor 1 (SDF-1), the principal regulator of BM-cell trafficking. Furthermore, SDF-1 stimulation by COMP-Ang1 was blocked by small-interfering RNA (siRNA) against hypoxia-inducible factor-1α (HIF-1α). COMP-Ang1 increased the synthesis of HIF-1α by activating mammalian target of rapamycin (mTOR) in hypoxic endothelium. The intermediate mechanism transmitting the COMP-Ang1 signal to the downstream mTOR/HIF-1α/SDF-1 pathway was the enhanced binding of the Tie2 receptor with integrin-linked kinase (ILK), an upstream activator of mTOR. In the mouse ischemic model, local injection of COMP-Ang1 stimulated the incorporation of BMPCs into ischemic limb, thereby enhancing neovasculogenesis and limb salvage. Collectively, our findings identify the COMP-Ang1/HIF-1α/SDF-1 pathway as a novel inducer of BMPC recruitment and neovasculogenesis in ischemic disease.
Twelve cases of tick-bite among humans in Kochi Prefecture (1990)

Twelve human cases of ixodid tick-bite in Kochi Prefecture, Japan, since 1982 were recorded. Causative tick species were : Ixodes nipponensis (5 cases), Amblyomma testudinarium (3 cases), Haemaphysalis longicornis (3 cases), and I. ovatus (1 case).
High density lipoprotein structure (2003)

HDL particles possess important antiatherogenic functionalities and understanding of the molecular mechanisms underlying these effects requires detailed knowledge of HDL structure. This review summarizes current understanding of HDL structure. The various HDL subclasses are compared in terms of their lipid and protein compositions. The lipid-binding properties of the principal HDL apolipoprotein, apo A-I, permit plasticity in HDL structure. The amphipathic alpha-helical domains that are the major element of secondary structure mediate the interaction of apo A-I with phospholipid. Low resolution models of the structures of both discoidal and spherical HDL particles are evaluated. HDL particles are dynamic in that they are being remodeled constantly in vivo by interaction with lipases, lipid transfer proteins, and cell-surface HDL receptors. Current knowledge of the ways in which HDL particle structure is modulated by interactions with proteins such as LCAT, CETP, SR-BI and ABCA1 is reviewed.
Design and implementation of SIP B2BUA server (2013)

The SIP(Session Initiation Protocol) is the core control protocol of the Next Generation Networks(NGN), which is used for initiating, modifying and tearing down multimedia sessions on IP data network. Because the SIP server is the core facility of NGN, its realization is especially important. One way to realize the SIP server is the proxy server, which mainly provides routing service. Namely, it ensures that request message will be sent to place that is closest to target user. However, the proxy server just keeps the state during the SIP interaction instead of the state during call process, which causes that the proxy server is limited to be used in more wide range. Another way is the B2BUA server, which keeps the state during the whole call process. So, at first, the Resiprocate is introduced from the basic principle of the SIP protocol in this paper, and the B2BUA server is realized. Then, taking advantage of the advantage of the B2BUA server, the group call system based on the B2BUA server is realized. At last, this paper use the SIPp, a open software which is specially used to test the SIP system, to test and analysis the performance of the B2BUA server.
Recognition of visual object classes (1996)

Humans can look at a scene or a photograph and easily recognize objects. Outside my window I can see cars, people walking a dog on a brick pathway, trees, buildings, etc. This perception is so effortless that it belies the difficulty of the task. Visual perception begins with light that is reflected from the scene into the eye. The light impinges upon the retina and is transduced by a two-dimensional array of photoreceptors into noisy electrical signals. The brain must then accomplish the difficult task of transforming from this low-level representation to a higher-level understanding of the scene in terms of regions, surfaces, textures, and objects. For computer vision the problem is the same, but the hardware is different. A camera approximates the function of the eye and retina; that is, the camera produces a two-dimensional array of numbers (pixel values) representing the intensity of light reflected from the scene. The fundamental question addressed in this thesis is the following: what mathematical processing should be applied to the pixel values in order for a computer to recognize objects? The methods we propose are not intended as a model of human brain function, although they may provide some insight. We are simply trying to solve the same visual recognition problems as the brain without concern for whether (or how) our algorithms could be realized in neuronal hardware. We have developed a new framework for recognizing visual object classes in which the class members consist of characteristic parts in a deformable spatial configuration. Human faces are an object class of this type, since faces consist of eyes, nose, and mouth arranged in a configuration that varies depending on expression and pose and also from one person to another. A second object class is cursive handwriting, which consists of loops, cusps, crossings, etc. arranged in a deformable pattern. In our approach, the allowed object deformations are represented through shape statistics, which are learned from examples. Instances of an object in an image are detected by finding the appropriate features in the correct spatial configuration. Our algorithm is robust with respect to partial occlusion, detector false alarms, and missed features. Potential applications include intelligent tools for finding objects in image data-bases, human-machine interfaces, user authentication, intelligent data gathering and compression, signature verification, and keyword spotting. Experimental results will be presented for two problems: (1) locating quasi-frontal views of human faces in cluttered scenes and with occlusions and (2) spotting keywords in on-line cursive handwriting data.
A Fully Implicit Parallel EOS Compositional Simulator for Large Scale Reservoir Simulation (1999)

Abstract A fully implicit parallel equation-of-state (EOS) compositional simulator for large-scale reservoir simulation is presented. This simulator is developed under the framework named IPARS (Integrated Parallel Accurate Reservoir Simulator) and is constructed using a Newton-type formulation. The Peng-Robinson EOS is used for the hydrocarbon phase behavior calculations. The linear solvers from the PETSc package (Portable Extensible Toolkit for Scientific Computation) are used for the solution of the underlying linear equations. The framework provides input/output, table lookups, Fortran array memory allocation, domain decomposition, and message passing between processors for updating physical properties in mass-balance equations in overlapping regions. PETSc handles communications between processors needed for the linear solver. Many test runs were performed with up to four million gridblocks for a dry-gas injection process on an IBM SP machine and half a million gridblocks on a cluster of 16 PCs. Results indicate that the scalability of the simulator is very good. The linear solver takes around half of the total computational time for homogeneous reservoirs. For layered heterogeneous reservoirs, the linear solver took a larger fraction of the total computational time as the permeability contrast increased. The time for the communication between processors for updating the flow equations is insignificant. The PC cluster is roughly a factor of two slower than the SP for parallel runs, which is very encouraging. This factor is strongly related to the hardware configuration of the computers, which is detailed in the paper.
Liquid phase sintering of rare earth–iron (Dy0.7Tb0.3Fe2) magnetostrictive materials (1978)

A liquid phase powder metallurgy method has been evaluated for the production of dense, thermally stable Dy0.7Tb0.3Fe2 compacts. The method involved the use of a rare earth rich alloy which forms the RFe2 phase and a RFe2-R eutectic. The latter is molten at the sintering temperature employed. Dy0.7Tb0.3Fex alloys ranging in composition from x=1.65 to stoichiometric were ground, aligned, compacted and then sintered between 1130 and 1190 °C. Densities as high as 98% were achieved for compositions between x=1.65 and 1.8. Densities were markedly lower for compositions beyond x=1.8. Although the magnetostriction of the compacts were lower than those found for cast polycrystalline Dy0.7Tb0.3Fe2, the magnetomechanical coupling coefficients (k33) of a number of the sintered compacts appeared to be as much as 50% higher than for the cast materials. Suprisingly, the highest coupling was found for samples with 5 to 15% porosity. When aged in air at 150 °C, the magnetoelastic properties of the liquid phase sintered materials were as stable as cast polycrystalline alloy.
Numerical simulation of puncture tests (1995)

A nonlinear dynamic numerical analysis, including failure analysis, has been developed to simulate the response of a cask under puncture.
VARU Framework: Enabling Rapid Prototyping of VR, AR and Ubiquitous Applications (2008)

Recent advanced interface technologies allow the user to interact with different spaces such as Virtual Reality (VR), Augmented Reality (AR) and Ubiquitous Computing (UC) spaces. Previously, human computer interaction (HCI) issues in VR, AR and UC have been largely carried out in separate communities. Here, we combine these three interaction spaces into a single interaction space, called Tangible Space. We propose the VARU framework which is designed for rapid prototyping of a tangible space application. It is designed to provide extensibility, flexibility and scalability. Depending on the available resources, the user could interact with either the virtual, physical or mixed environment. By having the VR, AR and UC spaces in a single platform, it gives us the possibility to explore different types of collaboration across the different spaces. As a result, we present our prototype application which is built using the VARU framework.
Designed water-soluble macrocyclic esterases: from nonproductive to productive binding (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesigned water-soluble macrocyclic esterases: from nonproductive to productive bindingFrancois Diederich, Gregor Schuermann, and Ito ChaoCite this: J. Org. Chem. 1988, 53, 12, 2744–2757Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/jo00247a017https://doi.org/10.1021/jo00247a017research-articleACS PublicationsRequest reuse permissionsArticle Views406Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Photochemical Route for Accessing Amorphous Metal Oxide Materials for Water Oxidation Catalysis (2013)

Large-scale electrolysis of water for hydrogen generation requires better catalysts to lower the kinetic barriers associated with the oxygen evolution reaction (OER). Although most OER catalysts are based on crystalline mixed-metal oxides, high activities can also be achieved with amorphous phases. Methods for producing amorphous materials, however, are not typically amenable to mixed-metal compositions. We demonstrate that a low-temperature process, photochemical metal-organic deposition, can produce amorphous (mixed) metal oxide films for OER catalysis. The films contain a homogeneous distribution of metals with compositions that can be accurately controlled. The catalytic properties of amorphous iron oxide prepared with this technique are superior to those of hematite, whereas the catalytic properties of a-Fe(100-y-z)Co(y)Ni(z)O(x) are comparable to those of noble metal oxide catalysts currently used in commercial electrolyzers.
High Rate and Highly Selective SiO<sub>2</sub> Etching Employing Inductively Coupled Plasma (1994)

Plasma and SiO 2 etching characteristics employing inductively coupled plasma (ICP) were studied with respect to distance from an antenna. Measurement of the ratio of electron to ion saturation currents in CHF 3 plasma shows an increase in negative fluorine ions in the downstream regions. The intensity ratio of C 2 (516.5 nm)/F(685.6 nm) also indicates high carbon-concentration in the downstream region. Further more, addition of H 2 to C 4 F 8 , which has more carbon species, yielded higher C 2 /F ratio. Accordingly, it was found that selectivity of SiO 2 /Si was remarkably enhanced by adding a higher concentration of H 2 to C 4 F 8 in the downstream region. The favorable results are due to the sheetlike characteristics of ICP. Since the plasma is confined near a quartz plate, HF molecules generated from the reaction of H atoms with F atoms do not undergo dissociation in the diffusive region. Thus high-speed pumping of HF is considered to suppress Si etching and in turn, to allow highiy selective SiO 2 etching.
Anti-HER2 antibody and heregulin suppress growth of HER2-overexpressing human breast cancer cells through different mechanisms. (2000)

Previous reports have shown that certain anti-HER2 antibodies and heregulin can inhibit clonogenic growth of breast and ovarian cancers that overexpress HER2. Anti-HER2 antibodies bind to HER2 directly, whereas heregulin does not bind to HER2 alone, but rather interacts with HER2 through the formation of heterodimers with HER3 or HER4. The purpose of the present study was to elucidate the mechanisms by which anti-HER2 antibody and heregulin inhibit tumor growth. The anti-HER2 monoclonal antibody (mAb) ID5 was found to block G1-S progression of the cell cycle, whereas heregulin inhibited passage through G2-M. Compatible with the effects on the cell cycle, treatment with mAb ID5 decreased levels of cyclin-dependent kinase (CDK) 2, cyclin E, and CDK6 proteins and reduced cyclin E-CDK2-associated kinase activity; mAb HD5-treated cells had increased p27Kip1 expression and an increased association of p27Kip1 with CDK2. In contrast, treatment with heregulin increased protein levels of CDK2, CDK6, CDC2, and cyclin B1. More Retinoblastoma protein was found in the hypophosphorylated state in the cells treated with mAb ID5, whereas more retinoblastoma protein was in the hyperphosphorylated state in heregulin-treated cells. Heregulin was able to induce cell differentiation as assessed by Oil Red O staining and apoptosis as assessed by sub-G1 peak on flow cytometry and the presence of DNA fragmentation in ApopTag histochemistry staining. Neither differentiation nor apoptosis was observed in the cells treated with mAb ID5. We conclude that anti-HER-2 mAb ID5 and heregulin exert growth inhibition through different mechanisms. In mammary cells overexpressing HER2, anti-HER2 mAb ID5 induces G1 arrest, whereas heregulin induces G2-M arrest, cell differentiation, and apoptosis.
Deploying Sensor Networks With Guaranteed Fault Tolerance (2009)

We consider the problem of deploying or repairing a sensor network to guarantee a specified level of multipath connectivity ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> -connectivity) between all nodes. Such a guarantee simultaneously provides fault tolerance against node failures and high overall network capacity (by the max-flow min-cut theorem). We design and analyze the first algorithms that place an almost-minimum number of additional sensors to augment an existing network into a <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> -connected network, for any desired parameter <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> . Our algorithms have provable guarantees on the quality of the solution. Specifically, we prove that the number of additional sensors is within a constant factor of the absolute minimum, for any fixed <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> . We have implemented greedy and distributed versions of this algorithm, and demonstrate in simulation that they produce high-quality placements for the additional sensors.
A novel pathogenic large germline deletion in adenomatous polyposis coli gene in a Chinese family with familial adenomatous polyposis (2016)

Germline mutations of the APC gene are associated with an autosomal dominant precancerous condition, termed familial adenomatous polyposis (FAP). FAP is clinically manifested by the presence of multiple colorectal adenomas or polyps. Gradually, these colorectal adenomas or polyps inevitably result in colorectal cancer by the third-to fourth decade of life. Surgical interventions or total proctocolectomy is the best possible treatment for FAP. Here, we present a clinical molecular study of a five generation Chinese family with FAP. Diagnosis of FAP was made on the basis of clinical manifestations, family history and medical (colonoscopy and histopathology) records. Blood samples were collected and genomic DNA was extracted. Genetic screening of the APC gene was performed by targeted next-generation sequencing and quantitative real-time PCR. Targeted next generation sequencing identified a novel heterozygous large deletion [exon5-exon16; c.423_8532del] of APC gene, which segregated with the FAP phenotypes in the proband and in all the affected family members. Unaffected family members and normal controls did not carry this deletion. In the Chinese population, most of the previously reported APC gene mutations are missense mutations. This is the first report describing the largest deletion of the APC gene in the Chinese population associated with FAP.
M.H.D. Diagnostics - Gas Temperature and Emittance (1960)

Gas temperature and emittance are examples of significant parameters that are common to both combustion and anticipated M.H.D. instrumentation. Such developed radiation techniques for temperature measurement as Line Reversal, Two Path, Two Color and Population method are reviewed, The Schmidt method.
Classification of Distinct Baseline Insulin Infusion Patterns in Children and Adolescents With Type 1 Diabetes on Continuous Subcutaneous Insulin Infusion Therapy (2007)

Pediatric diabetologists shape distinct basal insulin infusion rate profiles during treatment of CSII patients, mainly reflecting differences in age. Our data strongly suggest that age-dependent endocrine changes during childhood (e.g., puberty) affect circadian distribution of insulin needs in CSII, which should be kept in mind when considering basal insulin infusion rate strategies in children and adolescents.
Germany's Anti‐Foreigner Crisis: State Disunity and Collective ‘Forgetting’ (1994)

Abstract: Employment of foreign labor in Germany is generally perceived as a recent phenomenon; Germany's pre‐war experiences with foreign labor do not figure prominently in public discussion. This article analyzes the active omission of this aspect of the past as an important feature of German social memory. Drawing largely on Ulrich Herbert's research, the forgotten’ history of pre‐ and post‐war experiences with foreign labor is summarized. This provides a perspective on the significant parallels between conflicts today and those of prior periods and exposes a fundamental conflict within the state regarding the use of foreign labor. Anti‐foreigner violence is reinterpreted as representing a failure of the state to maintain ideological unity without periodically responding to powerful and enduring anti‐foreigner pressure.
Polymer Compatibilization: Blends of Polyarylethers with Styrenic Interpolymers (1979)

The polymer compatibilization concept is to modify advantageously the mechanical properties of a normally incompatible mixture by the addition of a suitable compatibilizing agent consisting usually of a block or graft copolymer. These interpolymers act as interfacial bridges between the components in the mixture. In this work, the 'compatibilization concept' is invoked, but pendant chemical groups are the compatibilizing agents rather than the more usual copolymers. Nitrile and/or ester groups have been attached conveniently to the backbone of a series of polyarylethers to compatibilize the ethers with αmethyl styrene/methyl methacrylate/acrylonitrile interpolymers. The choice of the appropriate pendant chemical groups was made on the basis of the observation that the styrene interpolymers are miscible with polymers that contain these specific groups.
IRRIGATION BY POSTERIOR SUCTION: ITS USE IN TREATMENT OF SUBACUTE AND EARLY CHRONIC POSTERIOR SINUSITIS (1939)

The principle of displacement described by Proetz has undoubtedly added immensely to the successful diagnosis and treatment of ailments in the posterior sinuses, particularly the sphenoid sinuses. A minor variation of this original method, namely irrigation with gentle suction, affords an additional method of diagnosis and treatment of the entire ethmoid group of cells, except those comprising the most anterior portion of the ethmoid capsule. Proetz<sup>1</sup>recently, in evaluating his method, described what he has named "washing through." This is "the application of continuous suction at one nostril while a treatment solution is being poured into the other." N. Asherson<sup>2</sup>reported a series of cases of children successfully treated in this manner. Over a period of three years we have used this method in the treatment of subacute residual ethmoiditis following "colds," of chronic hyperplastic conditions of the posterior ethmosphenoid sinuses associated with postnasal drip and headache and of retrobullbar