gebhart/patrepeval huggingface dataset:
Dexamethasone 21-(.beta.-isothiocyanatoethyl)thio ether: a new affinity label for glucocorticoid receptors (1991)

The C-21 methanesulfonate ester of the synthetic glucocorticoid dexamethasone (Dex) is an efficient electrophilic affinity label of glucocorticoid receptors and exhibits irreversible antiglucocorticoid activity. In an effort to obtain other affinity labeling steroids with differing biological activities, several new derivatives of Dex were prepared which contained a reactive electrophilic substituent at various distances from the C-21 position. All compounds displayed relatively low affinity for rat glucocorticoid receptors (less than or equal to 8% of that of Dex) in a cell-free competition assay. Nevertheless, one compound, dexamethasone 21-(beta-isothiocyanatoethyl) thioether (Dex-NCS), appeared to be an affinity label by virtue of its ability to block the cell-free exchange binding of [3H]Dex. [3H]Dex-NCS was thus synthesized and reacted with cell-free receptors to give, after analysis on denaturing SDS-polyacrylamide gels, only one specifically labeled species at 98 kDa, which is the molecular weight of authentic rat glucocorticoid receptor. These data directly establish Dex-NCS as a new affinity label for glucocorticoid receptors. Data on the reactivity of Dex-NCS and the stability of [3H]Dex-NCS-labeled receptors suggest that a cysteine SH group has been labeled.
MEDIO SIGLO DE ARQUITECTURA, PARA ENTENDER ESTA DISCIPLINA Y EL ARTE DE CONSTRUIR (1994)

EN LA PRESENTACION DEL LIBRO MEDIO SIGLO DE ARQUITECTURA. HISTORIA Y TENDENCIAS, EL MAESTRO XAVIER CORTES ROCHA, DIRECTOR DE LA FACULTAD DE ARQUITECTURA (FA) COMENTO QUE ESTE OBRA, DEL IVAN SAN MARTIN CORDOBA, ESTA LLAMADO A SER UN AUXILIAR IMPORTANTE EN LOS CURSOS DE HISTORIA Y DE LA ARQUITECTURA QUE SE IMPARTEN EN ESTA FACULTAD.
Stearoyl-Acyl Carrier Protein and Unusual Acyl-Acyl Carrier Protein Desaturase Activities Are Differentially Influenced by Ferredoxin (2000)

Acyl-acyl carrier protein (ACP) desaturases function to position a single double bond into an acyl-ACP substrate and are best represented by the ubiquitous Delta9 18:0-ACP desaturase. Several variant acyl-ACP desaturases have also been identified from species that produce unusual monoenoic fatty acids. All known acyl-ACP desaturase enzymes use ferredoxin as the electron-donating cofactor, and in almost all previous studies the photosynthetic form of ferredoxin rather than the non-photosynthetic form has been used to assess activity. We have examined the influence of different forms of ferredoxin on acyl-ACP desaturases. Using combinations of in vitro acyl-ACP desaturase assays and [(14)C]malonyl-coenzyme A labeling studies, we have determined that heterotrophic ferredoxin isoforms support up to 20-fold higher unusual acyl-ACP desaturase activity in coriander (Coriandrum sativum), Thunbergia alata, and garden geranium (Pelargonium x hortorum) when compared with photosynthetic ferredoxin isoforms. Heterotrophic ferredoxin also increases activity of the ubiquitous Delta9 18:0-ACP desaturase 1.5- to 3.0-fold in both seed and leaf extracts. These results suggest that ferredoxin isoforms may specifically interact with acyl-ACP desaturases to achieve optimal enzyme activity and that heterotrophic isoforms of ferredoxin may be the in vivo electron donor for this reaction.
Improvement of character recognition and generation techniques in facsimile communication systems (2003)

Novel techniques are described for hand-printed numeral recognition and generation of various-sized high-quality graphic characters, which permit efficient communications between facsimile terminals and computer centers. To achieve extremely precise numeral recognition despite the poor characteristics of the images obtained by facsimile terminals, a supplementary preprocessing method and a similar-shaped-character distribution method have been developed. Using these procedures, about 80% of the characters which cannot be recognized by the basic recognition procedure are rendered recognizable. Transmission bit errors affect encoded facsimile signals of an entry sheet in the form of recognition degradation or failure of row detection mark length. The occurrence probability of these kinds of errors is estimated, and it is shown from the degree of recognition degradation that the impact is negligibly small from the standpoint of practical use. A novel smoothing method for code-to-pattern conversion has also been developed to improve the picture quality of graphic character patterns.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Tissue-Specific Proteolysis of Huntingtin (htt) in Human Brain: Evidence of Enhanced Levels of N- and C-Terminal htt Fragments in Huntington's Disease Striatum (2001)

Proteolysis of mutant huntingtin (htt) has been hypothesized to occur in Huntington's disease (HD) brains. Therefore, this in vivo study examined htt fragments in cortex and striatum of adult HD and control human brains by Western blots, using domain-specific anti-htt antibodies that recognize N- and C-terminal domains of htt (residues 181-810 and 2146-2541, respectively), as well as the 17 residues at the N terminus of htt. On the basis of the patterns of htt fragments observed, different "protease-susceptible domains" were identified for proteolysis of htt in cortex compared with striatum, suggesting that htt undergoes tissue-specific proteolysis. In cortex, htt proteolysis occurs within two different N-terminal domains, termed protease-susceptible domains "A" and "B." However, in striatum, a different pattern of fragments indicated that proteolysis of striatal htt occurred within a C-terminal domain termed "C," as well as within the N-terminal domain region designated "A". Importantly, striatum from HD brains showed elevated levels of 40-50 kDa N-terminal and 30-50 kDa C-terminal fragments compared with that of controls. Increased levels of these htt fragments may occur from a combination of enhanced production or retarded degradation of fragments. Results also demonstrated tissue-specific ubiquitination of certain htt N-terminal fragments in striatum compared with cortex. Moreover, expansions of the triplet-repeat domain of the IT15 gene encoding htt was confirmed for the HD tissue samples studied. Thus, regulated tissue-specific proteolysis and ubiquitination of htt occur in human HD brains. These results suggest that the role of huntingtin proteolysis should be explored in the pathogenic mechanisms of HD.
An argon laser interferometer for the detection of gravitational radiation (1979)

The instrument described is used to locate and study various noise sources and other disturbances, which would restrict signal perceptibility. From an analysis of these disturbances, the demands on apparatus components are estimated. Some constructional details are given, as well as suggestions for improvement aimed at a future interferometer of increased base length, with the prospect of successful operation.
The Use of Glutamic Acid as Corrosion Inhibitor for Aluminium in Hcl Solution (2014)

The adsorptive and inhibitive action of glutamic acid towards general and pitting corrosion of aluminium in HCl solution was investigated using weight loss, gasometric and thermometric methods. Glutamic acid was found to inhibit the corrosion of aluminium in HCl solution. The inhibition efficiency of glutamic acid decreased with increase in temperature, period of immersion and HCl concentration, but increased with increasing glutamic acid concentration. Adsorption characteristics of glutamic acid have also been studied and it was found that the process obeys physical adsorption. Thermodynamic parameters including; E a , Q ads , S ads , H ads and G ads for the adsorption process signifies a spontaneous process. While Langmuir, Frumkin, Flory-Huggins and El-Awardy isotherm adsorption models can be used to explain the mechanism of glutamic acid adsorption onto aluminium surface in HCl solution.
on Quantized Frame Expansions with Erasures 1 (2008)

Frames have been used to capture significant signal characteristics, provide numerical stability of reconstruction, and enhance resilience to additive noise. This paper places frames in a new setting, where some of the elements are deleted. Since proper subsets of frames are sometimes themselves frames, a quantized frame expansion can be a useful representation even when some transform coefficients are lost in transmission. This yields robustness to losses in packet networks such as the Internet. With a simple model for quantization error, it is shown that a normalized frame minimizes mean-squared error if and only if it is tight. With one coefficient erased, a tight frame is again optimal among normalized frames, both in average and worst-case scenarios. For more erasures, a general analysis indicates some optimal designs. Being left with a tight frame after erasures minimizes distortion, but considering also the transmission rate and possible erasure events complicates optimizations greatly. © 2001 Academic Press 1.
An exceptionally simple and efficient method for the preparation of a wide variety of fulvenes (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn exceptionally simple and efficient method for the preparation of a wide variety of fulvenesKeith J. Stone and R. Daniel LittleCite this: J. Org. Chem. 1984, 49, 11, 1849–1853Publication Date (Print):June 1, 1984Publication History Published online1 May 2002Published inissue 1 June 1984https://pubs.acs.org/doi/10.1021/jo00185a001https://doi.org/10.1021/jo00185a001research-articleACS PublicationsRequest reuse permissionsArticle Views3365Altmetric-Citations298LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel method of multiplexing radiocommunication antennas using circular-array configuration (1983)

This paper describes the application of a circular array for the central antenna of base/repeater stations in mobile communication systems. The antenna is fed from a multiple-port feed network, which offers a number of electrically independent patterns which have omnidirectional coverage. The nature of the network is described showing how it can provide isolation between multiple transmitters and receivers. Experimental results are presented which suggest that 30 dB isolation can be achieved over an octave bandwidth.
Design of 2-D multiplierless filters using the genetic algorithm (2001)

When digital filters are designed with power-of-two coefficients, the multiplications can be implemented by simple shifting operations. In this paper, the genetic algorithm (GA) is used to design 2D multiplierless filters. The 2D filter is designed to have periodically shift variant (PSV) coefficients. This increases the degrees of freedom for the multiplierless coefficients so that a better approximation can be achieved. The design involves finding the impulse response of the 2D PSV filter in closed form and then using the GA to find the filter coefficients. Two different types of GA are used, namely, the Binary-GA and the Integer-GA. Some design examples are presented to illustrate the concepts.
Tetracyclines Modulate Protease-Activated Receptor 2-Mediated Proinflammatory Reactions in Epidermal Keratinocytes (2009)

In addition to their antibiotic effects, tetracyclines have anti-inflammatory action that is often beneficial in the control of inflammatory skin disorders. In this study, we examined the effects of tetracycline (TET) and two of its derivatives, doxycycline (DOX) and minocycline (MIN), on the production of interleukin-8 (IL-8) elicited by the activation of protease-activated receptor 2 (PAR2) in normal human epidermal keratinocytes (NHEK). In NHEK, the production of IL-8 stimulated by an agonist peptide of PAR2, SLIGKIV-NH(2), at 100 microM was significantly reduced by TET, DOX, or MIN at 5 and 10 microM, concentrations that are noncytotoxic. The tumor necrosis factor alpha (TNF-alpha)-induced production of IL-8 was synergistically augmented by SLIGKIV-NH(2), and that synergistic increase in the production of IL-8 was suppressed by 100 nM PAR2-specific small interfering RNA. It was also suppressed by TET, DOX, or MIN but not by the 14-membered-ring macrolide antibiotics erythromycin, roxithromycin, and clarithromycin, which also have anti-inflammatory activities, at 10 microM. These results suggest that tetracyclines attenuate the PAR2-IL-8 axis in keratinocytes and thereby effectively modulate proinflammatory responses in the skin.
Basic control of unified power flow controller (1997)

A unified power flow controller (UPFC) is a typical FACTS device capable of instantaneous control of three power system parameters. This paper presents a basic control system which enables the UPFC to follow the changes in reference values of the active and reactive power supplied from the outer system controller. The analysis is based on the transformation of the three-phase power system to the rotating reference frame. As a step closer to a practical application of the UPFC, a modified control structure with a predictive control loop and precontrol signal for a DC-voltage control was designed. The new control system offers better stability and transient performance in comparison with the classical decoupled strategy, especially considering the harmonic distortion of the current being controlled. The derived basic control of the UPFC was tested with the NETOMAC program system.
Activation of Zn acceptors in AlGaInP epitaxial layers grown on misoriented substrates by metal organic chemical vapour deposition (1992)

Activation of the Zn acceptors in AlGaInP epitaxial layers grown on misoriented substrates by metal organic chemical vapour deposition (MOCVD) has been successfully improved using post-heat treatment. The p-type carrier concentration and electrical activity in the (Al0.65Ga0.35)0.5In 0.5P layers were 1.8 × 1016cm-3 and 0.7, respectively. Activation of the Zn acceptors was found to be attributable to the hydrogen in the AIGaInP layer.
The PPARγ ligand rosiglitazone influences triacylglycerol metabolism in non-obese males, without increasing the transcriptional activity of PPARγ in the subcutaneous adipose tissue (2008)

PPARgamma is obligatory for fat mass generation and is thought to determine the amount of TAG stored per fat cell. We investigated whether ligand availability for PPARgamma is rate limiting in fat mass generation and substrate metabolism. Twenty healthy men (20-29 years) were randomly assigned to receive the PPARgamma ligand rosiglitazone (RSG) (8 mg/d) (n 10) or a placebo (n 10) during a stay of 7 d in a respiration chamber. Food intake was ad libitum, resulting in positive energy balances of 32.2 MJ (placebo) and 44.7 MJ (RSG). Fat cell size and expression of PPARgamma, adipocyte fatty acid-binding protein (aP2), adipsin, adiponectin and fasting-induced adipose factor (FIAF) were determined in subcutaneous abdominal fat biopsies. The total amount of fat stored and the amount of TAG per fat cell were not different between groups. For the entire group, fat cell size was decreased after overeating (P = 0.02). FIAF mRNA levels were decreased after overeating in the RSG group (P = 0.01), with a trend towards a decrease in the placebo group. Unexpectedly, RSG treatment did not influence the expression levels of PPARgamma and of the PPARgamma responsive genes aP2, adiponectin and adipsin. In addition, RSG resulted in a larger increase in plasma TAG during overeating than placebo treatment. These results suggest that in healthy, non-obese males the PPARgamma ligand RSG influences TAG metabolism, independent of its PPARgamma transcriptional activity in the subcutaneous adipose tissue.
Gymnemic acid V, VI and VII from Gur-ma, the leaves of Gymnema sylvestre R. Br. (1989)

From the leaves of Gymnema sylvestre were isolated three new saponins named gymnemic acid V (1), VI (2) and VII (3), besides the known saponins gypenoside II, V, XLIII, XLV, XLVII LXXIV and gynosaponin TN-2. Their structures were elucidated on the basis of spectral and chemical evidence. 1 and 2 of the three new saponins had antisweet activity.
Characteristics of Galacturonic Acid Oligomers as Elicitors of Casbene Synthetase Activity in Castor Bean Seedlings (1984)

Partial digestion of polygalacturonic acid with polygalacturonase isolated from Rhizopus stolonifer produces a mixture of alpha-1,4-d-galacturonide oligomers which act to elicit casbene synthetase activity in castor bean (Ricinus communis L). These oligomers were separated by anion exchange chromatography on DEAE Sephadex A-25 into discrete sizes and their degrees of polymerization were analyzed by fast atom bombardment mass spectrometry. A minimum degree of polymerization of nine units appears to be required for elicitor activity; trideca-alpha-1,4-d-galacturonide was the most active of the oligomers tested. Methyl-esterification of the carboxylate groups greatly diminishes the elicitor activity of the oligomers, a finding which suggests a requirement for the polyanionic character of the oligomers for full activity. The fact that a number of other polyanionic polymers tested as casbene synthetase elicitors did not show significant activity indicates that structural features other than the polyanionic character are also necessary for activity.
WebVideo. A tool for WWW-based teleoperation (2002)

The Internet and the WWW are a ubiquitous network with a media rich interface. WWW browsers display text, graphics, video, audio and data in open and proprietary formats. Forms convey input from the user to the server. Video and form-based feedback in the WWW allow remote control and teleoperation over the Internet, taking advantage of the relatively cheap, ubiquitous bandwidth and advanced user interfaces. The authors present a scheme to distribute multiple realtime video and data streams from a variety of sources and the interface to the controlled equipment. WebVideo for Windows and UNIX are server programs to send video from various sources (cameras, RGB-instrument-output, bitmap displays, computer generated animations) in many formats (RGB, RGB-RLE, JPEG, GIF) to multiple client browsers at the same time. The WebVideo server measures the available bandwidth and generates individual videostreams. To optimize performance, they introduce the CE/SC (Component Encoding/Stream Composition) mechanism to build multiple individually coded videostreams while the computationally intensive video compression is performed only once.
Tag-compass: Determining the spatial direction of an object with small dimensions (2017)

Identifying an object's spatial direction (or orientation) plays a fundamental role in a variety of applications, such as automatic assembly, indoor navigation, and robot driving. In this paper, we design a fine-grained direction finding system called Tag-Compass that attaches a single tag to an object (whose size may be small) and identifies the tagged object's orientation by determining the spatial direction of the tag. We exploit the polarization properties of the RF waves used in the communications between an RFID reader and the tag on the object. Polarization mismatch between the tag and the reader's antenna affects the received signal strength at the reader. From the measured signal strength values, we are able to deduce the tag's direction through a series of transformations and deviation minimization. We propose a system design for Tag-Compass and implement a prototype. We evaluate the performance of TagCompass through extensive experiments using the prototype. The experimental results show that Tag-Compass provides accurate direction estimates with a median error of just 2.5° when the tag's position is known and a median error of 3.8° when the tag's position is unknown.
Molecular Cloning and Characterization of Functional Domains of a Human Testis-Specific Isoform of Calpastatin1 (2000)

Human serum containing sperm-agglutinating antibodies was used to screen a testis cDNA expression library to identify the cognate antigens that may be responsible for this biological effect. The longest positive phage clone (1.9 kb) was sequenced and found to be a testis-specific isoform of calpastatin (tCAST). The testis-specific segment of tCAST is encoded by a single exon within intron 14 of the calpastatin gene. A unique protein isoform is produced that differs in domain structure from the somatic calpastatins (sCAST). Human sCAST most commonly has an N-terminal domain L plus the four functional calpain inhibitory domains. Human tCAST consists of a 40-amino-acid N-terminal T domain plus a part of domain II and all of domains III and IV from the somatic isoform. Our data show that the T domain can target cytosolic localization and membrane association of tCAST, whereas domain I of sCAST exhibits a nuclear localization function. Calpastatin is the endogenous inhibitor of calpain. The calpain/calpastatin system is involved in membrane fusion events for several cell types, and calpain has been localized to the sperm acrosome. We detected tCAST in human sperm and testes extracts by Western blotting with specific antisera. These observations suggest that tCAST may modulate calpain in the calcium-mediated acrosome reaction that is required for fertilization.
Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy (2008)

Oxygen-induced retinopathy (OIR) in the mouse, like the analogous human disease retinopathy of prematurity, is an ischemic retinopathy dependent on oxygen-induced vascular obliteration. We tested the hypothesis that chemically overriding the oxygen-induced downregulation of hypoxia-inducible factor (HIF) activity would prevent vascular obliteration and subsequent pathologic neovascularization in the OIR model. Because the degradation of HIF-1alpha is regulated by prolyl hydroxylases, we examined the effect of systemic administration of a prolyl hydroxylase inhibitor, dimethyloxalylglycine, in the OIR model. Our results determine that stabilizing HIF activity in the early phase of OIR prevents the oxygen-induced central vessel loss and subsequent vascular tortuosity and tufting that is characteristic of OIR. Overall, these findings imply that simulating hypoxia chemically by stabilizing HIF activity during the causative ischemia phase (hyperoxia) of retinopathy of prematurity may be of therapeutic value in preventing progression to the proliferative stage of the disease.