gebhart/patrepeval huggingface dataset:
Bent-sandwich derivatives of tantalum bearing one or two pentamethylcyclopentadienyl ligands (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBent-sandwich derivatives of tantalum bearing one or two pentamethylcyclopentadienyl ligandsVernon C. Gibson, John E. Bercaw, William J. Bruton, and Robert D. SannerCite this: Organometallics 1986, 5, 5, 976–979Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/om00136a023https://doi.org/10.1021/om00136a023research-articleACS PublicationsRequest reuse permissionsArticle Views359Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Anthocyanin Pigments of Sweet Potatoes–Ipomoea batatas (1992)

ABSTRACT The anthocyanin pigments of red sweet potato roots (Impomoea batatas) were isolated, purified and identified by HPLC and conventional paper chromatographic, spectral and chemical methods. Two major pigments and two minor pigments were present in fresh tissue slices extracted with boiling 1% HAc methanol. Tissues extracted cold yielded 11 or more pigments probably from degradation of the two major pigments. One major pigment was identified as peonidin‐3‐diglucoside‐5‐glucoside with three molecules of ferulic acid and one molecule of caffeic acid. The other major pigment was peonidin‐3‐diglucoside‐5‐glucoside with two molecules of ferulic acid and one caffeic acid.
Three-Transistor AMOLED Pixel Circuit With Threshold Voltage Compensation Function Using Dual-Gate IGZO TFT (2012)

In addition to the gate electrode at the bottom, a dual-gate amorphous InGaZnO4 thin-film transistor (TFT) has a secondary gate electrode on the top. The threshold voltage (Vth) of the TFT using the bottom gate in its normal operation can be controlled by the top gate. Based on this phenomenon, a simple circuit of active-matrix organic light-emitting diode using the top gate to compensate threshold voltage variation is proposed. This new pixel circuit uses only three TFTs and two capacitors. The validity of Vth compensation is verified experimentally.
Bone Loss following Hypogonadism in Men with Prostate Cancer Treated with GnRH Analogs (2002)

It is known that bone mineral density (BMD) is low in men who are hypogonadal. However, the rate and sites of bone loss following testosterone deficiency are not known. The resulting hypogonadism after GnRH analog therapy for the treatment of prostate cancer allows us to examine bone loss and bone resorption immediately after testosterone withdrawal. Therefore, we examined the effects of GnRH analog treatment on bone loss and bone resorption in men with prostate cancer. BMD and serum and urine concentrations of markers of bone turnover were determined in men with prostate cancer and in age-matched controls. Measurements were taken before GnRH therapy and 6 and 12 months after instituting therapy. After 12 months of GnRH therapy, the BMD of the total hip and ultra distal radius decreased significantly (P < 0.001) in men with prostate cancer compared with the controls. The mean bone loss was 3.3% and 5.3%, respectively. The observed reduction in BMD in the spine (2.8%) and the femoral neck (2.3%) did not reach statistical significance. No significant bone loss was observed in the control subjects. The concentration of the urine marker of bone resorption, N-telopeptide, was significantly increased from baseline and from controls at both 6 and 12 months in patients treated with GnRH analog therapy compared with control subjects (P < 0.05). The concentration of a serum marker of bone formation, bone-specific alkaline phosphatase, was not significantly different from baseline or from controls at 6 and 12 months. Thus, the decreased total hip and ultra distal radius BMD and increased urinary N-telopeptide concentration after testosterone withdrawal demonstrate an increase in trabecular bone loss and enhanced bone resorption. These findings demonstrate a significant loss of bone in men with prostate cancer after receiving GnRH therapy and suggest that the total hip and radius are the preferred sites for monitoring bone loss in older men. In addition, markers of bone resorption may be helpful.
Electrophoresis of individual microtubules in microchannels (2007)

We use micrometer-sized fluidic channels to confine and measure electrophoresis of freely suspended individual microtubules. We measure orientation-dependent velocities of microtubules and the electro-osmotic flow mobility in our channels to infer the anisotropic electrophoretic mobility of microtubules under physiological conditions. We discuss the difference between electrophoresis and purely hydrodynamic motion and its implications for interpreting mobility measurements. We show that the mobility anisotropy is a factor of 0.83, clearly different from the well known anisotropy factor of 0.5 in Stokes drag coefficients for cylindrical objects. We also show that the velocity is independent of microtubule length, which would be different for hydrodynamic motion. We demonstrate that the electric force on the counterions has important consequences for the interpretation of electrophoresis experiments and that ignoring this can lead to an underestimation of the effective charge by orders of magnitude. From the electrophoresis measurements, we calculate an effective surface-charge density of -36.7 +/- 0.4 mC/m2 for microtubules. Electrophoretic measurements of subtilisin-digested microtubules, which have the negatively charged C termini on the outer surface removed, show a 24% decrease in mobility and, correspondingly, in surface charge, but no change in anisotropy.
Living in the cold : physiological and biochemical adaptations : proceedings of the seventh international symposium on natural mammalian hibernation, held October 6-11, 1985, at the Stanford University Conference Center, Fallen Leaf Lake, California, U.S.A. (1986)

List of participants. Preface. Dedication. Special address: The Diversity of Temporal Heterothermy (G.A. Bartholomew). Session I. Biochemical and Cellular Aspects of Cold Adaptation and Acclimation . The adaptation to cold of membrane order and (Na + /K + )-ATPase properties. A critical role for membranes in hibernation. Membrane transport at low temperature in hibernators and non-hibernators. Control of membrane fludity in carp upon cold stress: studies on fatty acid desaturases. Gangliosides and synaptic transmission: effects of temperature. Temperature and smooth muscle automaticity. pH as a control factor in hibernation. Regulation of thermogenesis in brown adipose tissue: aspects of gene regulation. Alpha 1 -adrenergic pathways in brown adipose tissue: mode of action and recruitment pattern. Cold - versus diet-induced thermogenesis in brown adipose tissue: different strategies in different species. Regulation of brown fat thermogenesis in hibernators. Is brown fat necessary? Molecular biology of antifreeze. Insect cold hardiness: freezing tolerance and avoidance - the Eurosta model. Freeze tolerance in vertebrates: biochemical adaptation of terrestrially hibernating frogs. Session II. Thermoregulation. Nervous control of cold defense. Neural control of cold defense mechanisms in the avian thermoregulatory system. Neural pathways for transmission of thermal information: the role of the raphe nuclei. Regulation of heat circulation to the feet of mammals in chronic cold. Interactions between temperature and sleep regulations. CNS regulation of body temperature in hibernators and non-hibernators. Thermoregulation effect of serotonin in hibernation. Is heat production during arousal enhanced by positive feedback? Temperature regulation in heterothermic marsupials. Session III. Neural and Endocrine Aspects of Hibernation and Seasonal Cycles. Neural activity during mammalian hibernation. Functional aspects of brain opioid peptide systems in hibernation. Homologies between sleep factors and hibernation triggers. Reproductive development in hibernating ground squirrels. Hibernation in the hedgehog: influence of external and internal factors. Endocrine correlates of hibernation in the edible dormouse Glis glis. Seasonal variations in pancreatic function in marmots: the role of pancreatic hormones and lipoprotein lipase in fat deposition. Regulation of energy stores in arctic ground squirrels: brown fat thermogenic capacity, lipoprotein lipase and pancreatic hormones during fat deposition. Environmentally-determined physiological adjustments made in preparation for hibernation. Pineal and circadian rhythms. Role of photoperiod - pineal gland interaction in torpor control. Evidence for the involvement of pineal melatonin in the control of the hibernation cycle in (Spermophilus lateralis). Effects of prolonged short days on thermoregulation in the Djungarian hamster, Phodopus sungorus.
Phase III Trial of Gemcitabine Compared With Pegylated Liposomal Doxorubicin in Progressive or Recurrent Ovarian Cancer (2008)

GEM does not provide an advantage compared with PLD in terms of TTP in ovarian cancer patients who experience recurrence within 12 months after primary treatment but should be considered in the spectrum of drugs to be possibly used in the salvage setting.
Bupropion as an Antidote for Serotonin Reuptake Inhibitor-Induced Sexual Dysfunction (1998)

Bupropion administration may be a safe and effective method of treating SRI-induced sexual dysfunction. Placebo-controlled, double-blind studies are needed.
Nucleic acid recognizing Toll-like receptors as therapeutic targets: a focus on autoimmunity and cancer (2009)

Nucleic acid recognizing Toll-like receptors as therapeutic targets: a focus on autoimmunity and cancer Philipp YuInstitute for Immunology, Philipps-Universität-Marburg, Marburg, GermanyAbstract: The “trinity” of nucleic acid recognizing Toll-like receptors (TLRs) is the focus of intense research efforts. Among the plethora of pattern recognition receptors the ones that recognize RNA and DNA always seemed Janus-faced in their potential – dangerous, but also promising. Therefore manipulating TLR3, TLR7 and TLR9, which recognize dsRNA-, ssRNA and CpG-containing DNA, respectively, is a very attractive goal, because increasing evidence shows that both suppression or enhancement of the immune system might thereby be achieved. In this review we try to illustrate the current knowledge of the endosomal nucleic acid recognizing TLRs. We then want to extend our view beyond the pathogen recognizing capacity to their role in autoimmunity and cancer. Significant progress has been made in our understanding of the structure of TLRs, signaling pathways and ligand identity. The question of if and how we can translate this into new specific immunosuppressive drugs or anti-cancer adjuvants is discussed.Keywords: Toll-like receptors, immunosuppressive drugs, anti-cancer adjuvants
<title>SAMPSON smart inlet design overview and wind tunnel test: II. Wind tunnel test</title> (2002)

The Smart Aircraft and Marine System Projects Demonstration (SAMPSON) program was a DARPA funded effort conducted by the Boeing Company, General Dynamics - Electric Boat Division, and the Pennsylvania State University. NASA Langley Research Center (NASA LaRC) was technical monitor for the aircraft demonstration, while the Navy's Office of Naval Research (ONR) was technical monitor for the marine demonstration. Dr. Ephrahim Garcia, DARPA/DSO, acted as the DARPA program manager for SAMPSON. The SAMPSON program objectives were to demonstrate smart structures based systems on large/full scale structures in realistic environments. The SAMPSON aircraft demonstration was the wind tunnel testing of a full scale F-15 aircraft inlet that was capable of in-flight structural variations accomplished using smart materials, called the 'SAMPSON Smart Inlet'. The SAMPSON Smart Inlet was removed from an F-15E airframe and structurally modified to interface with the NASA LaRC 16-Foot Transonic Tunnel model support system. This is Part II of two works documenting the SAMPSON Smart Inlet design and testing. A discussion of the two wind tunnel tests will be presented here in Part II. The design of the shape changing components of the Smart Inlet is presented in a separate work, Part I.
Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study (2016)

Lung cancer ranks as the most common and lethal malignancy in America and worldwide. APOBEC3B is a newly identified DNA cytosine deaminase, which is supposed to function as a major source of DNA mutation in many different tumors. In this study, we combine the data of online databases and two hundred and twenty-one primary non-small-cell lung carcinoma (NSCLC) specimens from Sun Yat-sen University Cancer Center to investigate, for the first time, the clinical role of APOBEC3B in lung cancer. We found that the APOBEC3 expression was commonly elevated in NSCLC tissues and overexpression of APOBEC3B was correlated with unfavorable prognosis of the patients with NSCLC. Furthermore, APOBEC3B expression was associated with nodal status, TNM staging and adjuvant chemotherapy of the patients with NSCLC. Further research is warranted.
Development of rabbit zygotes into blastocysts in defined protein-free medium and offspring born following culture and embryo transfer (1997)

We report here on an improved, completely defined culture system for producing embryos in vitro which mimics development in vivo. This system avoids the confounding effects of the many unknowns introduced by the multivariate components of the serum or by unknowns attached to bovine serum albumin (BSA). Zygotes were obtained from superovulated rabbits and cultured in modified defined RPMI 1640:Dulbecco's MEM, 1:1 (RD) medium. The effect of a novel and potentially ideal antioxidant, tempol, was tested (20 to 0.001 mM) but found to be either toxic or ineffective. In the presence of 20% O(2), 600 units of Superoxide dismutase or 2.5 mM of taurine increased embryo hatching after 72 h of culture in RD medium to 75 and 76%, respectively, compared with 46% in the control (P < 0.05). The need for antioxidants was reduced with 5% O(2). The beneficial effects of RD medium were demonstrated when 60 zygotes cultured for 48 h to the early blastocyst stage in this medium were transferred and resulted in 30 young (50%) compared with 35/60 (58%) young from uncultured control transfers. Only 12% of the young were obtained from slower developing morulae. Thus, high viability was established for rapidly growing embryos in culture, but fewer slow growing embryos survived after transfer. A further comparison of embryos cultured in RD medium with a high potassium simple, optimized, defined medium (KSOM), revealed that both yielded results approaching those of direct transfer without culture. Simple defined media may also be useful for the culture of embryos of other species.
Robust Electrografting on Self-Organized 3D Graphene Electrodes (2015)

Improving graphene-based electrode fabrication processes and developing robust methods for its functionalization are two key research routes to develop new high-performance electrodes for electrochemical applications. Here, a self-organized three-dimensional (3D) graphene electrode processed by pulsed laser deposition with thermal annealing is reported. This substrate shows great performance in electron transfer kinetics regarding ferrocene redox probes in solution. A robust electrografting strategy for covalently attaching a redox probe onto these graphene electrodes is also reported. The modification protocol consists of a combination of diazonium salt electrografting and click chemistry. An alkyne-terminated phenyl ring is first electrografted onto the self-organized 3D graphene electrode by in situ electrochemical reduction of 4-ethynylphenyl diazonium. Then the ethynylphenyl-modified surface efficiently reacts with the redox probe bearing a terminal azide moiety (2-azidoethyl ferrocene) by means of Cu(I)-catalyzed alkyne-azide cycloaddition. Our modification strategy applied to 3D graphene electrodes was analyzed by means of atomic force microscopy, scanning electron microscopy, Raman spectroscopy, cyclic voltammetry, and X-ray photoelectron spectroscopy (XPS). For XPS chemical surface analysis, special attention was paid to the distribution and chemical state of iron and nitrogen in order to highlight the functionalization of the graphene-based substrate by electrochemically grafting a ferrocene derivative. Dense grafting was observed, offering 4.9 × 10(-10) mol cm(-2) surface coverage and showing a stable signal over 22 days. The electrografting was performed in the form of multilayers, which offers higher ferrocene loading than a dense monolayer on a flat surface. This work opens highly promising perspectives for the development of self-organized 3D graphene electrodes with various sensing functionalities.
Delivery Strategies for siRNA-mediated Gene Silencing (2006)

RNA interference (RNAi) represents a promising new gene silencing technology for functional genomics and a potential therapeutic strategy for a variety of genetic diseases. RNAi involves the targeted post-transcriptional degradation of messenger RNA thereby inhibiting the synthesis of the desired protein. This effectively leads to silencing of gene expression. The effectors of this process are short interfering RNA (siRNA) duplexes (approximately 21-23nt) that are key intermediaries in the specific degradation of target mRNA following incorporation into the RNA-induced silencing complex (RISC) in the cytosol. However, due to the large molecular weight and negative charge of siRNA duplexes the effective cellular uptake and intracellular delivery appear to represent a major challenge for the widespread use of RNAi in vivo. This review summarises some of the main delivery strategies that have been attempted for the transfection of siRNA to cells in vitro and in vivo.
Security in Computing, 4th Edition (2006)

The New State-of-the-Art in Information Security: Now Covers the Economics of Cyber Security and the Intersection of Privacy and Information SecurityFor years, IT and security professionals and students have turned to Security in Computing as the definitive guide to information about computer security attacks and countermeasures. In their new fourth edition, Charles P. Pfleeger and Shari Lawrence Pfleeger have thoroughly updated their classic guide to reflect today's newest technologies, standards, and trends.The authors first introduce the core concepts and vocabulary of computer security, including attacks and controls. Next, the authors systematically identify and assess threats now facing programs, operating systems, database systems, and networks. For each threat, they offer best-practice responses.Security in Computing, Fourth Edition, goes beyond technology, covering crucial management issues faced in protecting infrastructure and information. This edition contains an all-new chapter on the economics of cybersecurity, explaining ways to make a business case for security investments. Another new chapter addresses privacy--from data mining and identity theft, to RFID and e-voting.New coverage also includes Programming mistakes that compromise security: man-in-the-middle, timing, and privilege escalation attacks Web application threats and vulnerabilities Networks of compromised systems: bots, botnets, and drones Rootkits--including the notorious Sony XCP Wi-Fi network security challenges, standards, and techniques New malicious code attacks, including false interfaces and keystroke loggers Improving code quality: software engineering, testing, and liability approaches Biometric authentication: capabilities and limitations Using the Advanced Encryption System (AES) more effectively Balancing dissemination with piracy control in music and other digital content Countering new cryptanalytic attacks against RSA, DES, and SHA Responding to the emergence of organized attacker groups pursuing profit
The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression (2001)

Genes of the polycomb group function by silencing homeotic selector genes that regulate embryogenesis. In mice, downregulation of one of the polycomb genes, bmi-1, leads to neurological alterations and severe proliferative defects in lymphoid cells, whilst bmi-1 overexpression, together with upregulation of myc-1, induces lymphoma. An oncogenic function has been further supported in primary fibroblast studies where bmi-1 overexpression induces immortalization due to repression of p16/p19ARF, and where together with H-ras, it readily transforms MEFs. It was the aim of this study to assess the expression of bmi-1 in resectable non-small cell lung cancer (NSCLC) in association with p16 and p14ARF (=human p19ARF). Tumours (48 resectable NSCLC (32 squamous, 9 adeno-, 2 large cell, 4 undifferentiated carcinomas and 1 carcinoid); stage I, 29, II, 7, III, 12; T1, 18, T2, 30; differentiation: G1 12, G2 19, G3 17) were studied by immunohistochemistry for protein expression and by comparative multiplex PCR for gene amplification analysis. In tumour-free, normal lung tissue from patients, weak - moderate bmi-1 staining was seen in some epithelial cells, lymphocytes, glandular cells and in fibroblasts, whereas blood, endothelial, chondrocytes, muscle cells and adipocytes did not exhibit any bmi-1 expression. In tumours, malignant cells were negative/weakly, moderately and strongly positive in 20, 22 and 6 cases, respectively. As assessed by multiplex PCR, bmi-1 gene amplification was not the reason for high-level bmi-1 expression. Tumours with moderate or strong bmi-1 expression were more likely to have low levels of p16 and p14ARF (P = 0.02). Similarly, tumours negative for both, p16 and p14ARF, exhibit moderate-strong bmi-1 staining. 58% of resectable NSCLC exhibit moderate-high levels of bmi-1 protein. The inverse correlation of bmi-1 and the INK4 locus proteins expression (p16/p14ARF) supports a possible role for bmi-1 misregulation in lung carcinogenesis.
Analysis of Peer-to-peer Distributed Reputation Schemes (2006)

Peer-to-peer systems consist of groups of nodes acting as clients and servers. These groups of nodes communicate directly among themselves through wide-area networks. Some of the benefits of fully distributed peer-to-peer systems are scalability, resource aggregation and interoperability without any administration cost or centralized infrastructure support. In this context, reputation schemes aid the service requesters to choose the proper resource provider and to prevent malicious behaviors. This paper analyzes reputation management in fully distributed peer-to-peer systems. This paper discusses the main issues that a reputation framework must address and analyzes the most representative distributed reputation systems. This paper also discusses the main advantages and drawbacks of each proposal in relation to peer-to-peer reputation system requirements