gebhart/patrepeval huggingface dataset:
Characterisation of GaInP/GaAs double heterojunction bipolar transistors with different collector designs (1993)

The characteristics of InGaP/GaAs:C double-heterojunction bipolar transistors (DHBTs) with different collector layer designs are investigated and compared with those of a single heterojunction bipolar transistor. By inserting highly-doped n-type GaAs and InGaP layers in the collector, current saturation characteristics of a DHBT, comparable to those of a single heterojunction bipolar transistor, are achieved. The breakdown voltage of the DHBT was substantially higher than that of a single-heterojunction bipolar transistor with the same collector doping and thickness.
Metallic and Insulating Interfaces of Amorphous SrTiO<sub>3</sub>-Based Oxide Heterostructures (2011)

The conductance confined at the interface of complex oxide heterostructures provides new opportunities to explore nanoelectronic as well as nanoionic devices. Herein we show that metallic interfaces can be realized in SrTiO(3)-based heterostructures with various insulating overlayers of amorphous LaAlO(3), SrTiO(3), and yttria-stabilized zirconia films. On the other hand, samples of amorphous La(7/8)Sr(1/8)MnO(3) films on SrTiO(3) substrates remain insulating. The interfacial conductivity results from the formation of oxygen vacancies near the interface, suggesting that the redox reactions on the surface of SrTiO(3) substrates play an important role.
Gerontomodulatory and Youth-Preserving Effects of Zeatin on Human Skin Fibroblasts Undergoing Aging <i>In Vitro</i> (2005)

Our studies have shown that zeatin, (6-[4-hydroxy-3-methyl-but-2-enylamino]adenine), a cytokinin plant growth factor, has gerontomodulatory, youth preserving and anti-aging effects on serially passaged human adult skin fibroblasts undergoing aging in vitro. There were no immediate negative or toxic effects in terms of cell attachment, cell proliferation, cell survival, cytoskeletal organization, and cellular growth by treatment with zeatin concentrations between 1 and 200 microM. During long-term treatment, cells could be maintained throughout their replicative lifespan in the presence of 40, 80, and 200 microM zeatin, but the optimal concentration of zeatin's anti-aging and youth preserving effects was found to be 80 microM. Life-long serial passaging of human skin fibroblasts in the presence of zeatin resulted in the prevention of cell enlargement, reduction of intracellular debris, prevention of actin polymerization, and enhancement of cellular ability to decompose hydrogen peroxide and to cope with ethanol and oxidative stresses. Most importantly, anti-aging and beneficial effects of zeatin were observed without any induction of additional cell proliferation or an increase in the maximum proliferative capacity, thus ruling out any potentially harmful and carcinogenic effects.
A strategy to compute the InfiniBand arbitration tables (2002)

The InfiniBand Architecture (IBA) is a new industry standard architecture for server I/O and interprocessor communication. InfiniBand is very likely to become the de facto standard in a few years. It is being developed by the InfiniBand Trade Association (IBTA) to provide the levels of reliability, availability, performance, scalability, and quality of service (QoS) necessary for present and future server systems. The provision of QoS in data communication networks is currently the focus of much discussion and research in industry and academia. IBA enables QoS support with some mechanisms. In this paper, we examine these mechanisms and describe a way to use them. We propose a traffic segregation strategy based on mean bandwidth requirements. Moreover, we propose a very effective strategy to compute the virtual lane arbitration tables for IBA switches. We evaluate our proposal with different network topologies. Performance results show that, with a correct treatment of each traffic class in the arbitration of the output port, every traffic class meets its QoS requirements.
The preparation of reusable magnetic and photocatalytic composite nanofibers by electrospinning and atomic layer deposition (2008)

A versatile synthesis procedure for composite nanofibers, combining electrospinning and atomic layer deposition (ALD), is presented. Both solid core/sheath nanofibers and nanoparticle loaded nanotubes can be made, depending on the order of calcination of the electrospun fiber and the ALD process. Magnetic and photocatalytic nanofibers prepared this way can be recycled readily by collecting with a magnet.
Evidence for the close linkage between lymphocyte cytosol polypeptide with molecular weight of 64,000 (LCP1) and esterase D. (1985)

The genetic linkage of the loci for lymphocyte cytosol polypeptide with molecular weight of 64,000 (LCP1) and esterase (ESD) were examined by two-dimensional gel electrophoresis using blood from four informative families. No recombinants were observed in the four families totaling 17 children, giving a summed lod score of 4.221 at recombination fraction 0. This result indicates that the gene for LCP1 is closely linked to the ESD locus, which is assigned to the chromosomal region 13q14.11. This finding also suggests that the LCP1 locus is linked to the retinoblastoma gene, which is assigned to the same chromosomal region and closely linked to the ESD locus.
An analog front end for full-duplex digital transceivers working on twisted pairs (1989)

An analog front-end chip fabricated in a 4- mu m CMOS process has been described. The chip, together with a digital signal processor, implements a full-duplex transceiver for twisted pairs. A fully differential architecture has been used in all the analog signal-processing blocks to get high dynamic range and common-mode noise rejection. The front-end output is a 12-b word generated by a 6- mu s A/D (analog-to-digital) converter with autocalibration, with a linearity better than 1 LSB.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Relationship Between Prostatic Intraepithelial Neoplasia and Prostate Cancer: Critical Issues (1997)

There is convincing evidence that PIN is a precursor lesion to prostate cancer, with a close association of PIN and prostate cancer in biopsy and prostatectomy specimens. A biopsy finding of high grade PIN necessitates further investigation in patients who are candidates for radical treatment for localized prostate cancer.
Scheme configuration design for micro-assembly system based on product family and performance (2018)

In order to respond quickly to customer demand in micro-assembly system design, a configuration design method is proposed based on product family and performance simulation. In presented method, product scheme is generated rapidly by configuration reasoning based on product family model, which integrated with multi-domain knowledge. The product performance prediction is achieved based on simulation model that is established automatically with Modelica language. The multi-domain knowledge, which is expressed by feature parameters and constraints, is fused into the product family model, and the process of configuration reasoning and performance simulation are presented. The realization of configuration design guarantees flexibility of structure design and production of micro-assembly system. Finally, the feasibility of the method is verified on a developed mechanical arm of micro-assembly system.
ICDD'S New PDF-4 Organic Database: Search Indexes, Full Pattern Analysis and Data Mining (2004)

In an attempt to fill a gap between fully automatic search/match programs and purely manual methods based on paper products, a relational database plug-in has been developed that functions as a PC-based Search/Index program for extracting information from PDF-4 powder diffraction databases. The plug-in provides an adjustable search window and match window to account for experimental errors. Both Hanawalt (Hanawalt, J.D. and Rinn, H.W. (1936). Ind. Eng. Chem. Anal., 8, 244.; Hanawalt, J.D. (1976). Advances in X-Ray Analysis, 20, 63–73; Hanawalt, J.D. (1983). Crystalograplty in North America, Apparatus and Methods, Ch. 2, pp. 215–219. American Crystallographic Association.] and Fink [Bigelow, W. and Smith, J.V. (1965). ASTM Spec. Tech. Puhl. STP, 372, 54–89.] search methods are incorporated. In this article, we report search-indexing results obtained with the new PDF-4 plug-in applied to a new relational database, the PDF-4/Organics 2003. This database has 24 385 experimental entries and 122816 calculated patterns derived from the Cambridge Crystallographic Database (CSD). We introduce a goodness of match (GOM) parameter to describe the relative agreement between the experimental input data and selected reference patterns from the PDF-4/Organics 2003. The relevance of the GOM is illustrated in several example problems. Multiphase samples can be treated on a phase-by-phase basis.
Studies of the interactions of an MRI system with the shielding in a combined PET/MRI scanner (2009)

A positron emission tomography (PET) system or 'insert' has been constructed for placement and operation in the bore of a small animal magnetic resonance imaging (MRI) scanner to allow simultaneous MR and PET imaging. The insert contains electronics, components with a variety of magnetic properties and large continuous sheets of metal--all characteristics of an object that should, by conventional wisdom, never be placed in the bore of an MR scanner, especially near the imaging volume. There are a variety of ways the two systems might be expected to interact that could negatively impact the performance of either or both. In this article, the interaction mechanisms, particularly the impact of the PET insert and shielding on MR imaging, are defined and explored. Additionally, some of the difficulties in quantifying errors introduced into the MR images as a result of the presence of the PET components are demonstrated. Several different approaches are used to characterize image artifacts and determine optimal placement of the shielding. Data are also presented that suggest ways the shielding could be modified to reduce errors and enable placement closer to the isocenter of the magnet.
Adaptive filtering for selective elimination of higher harmonics from line currents of a voltage source converter (2002)

The methods for adaptive noise canceling have been well developed and researched in digital signal processing. The task is typically accomplished by generating a reference signal with frequency that should be eliminated from the primary input signal. The reference is filtered to match the interfering sinusoid in primary input. The weights of the adaptive filter are adjusted to totally eliminate the component with undesired frequency from the primary input, creating a tunable notch filter with an infinite null at selected frequency. The above concept was used as a basis for the development of an adaptive selective harmonic canceling (ASHC) algorithm. With ASHC added to the "regular" control of the VSC, the whole VSC becomes an active adaptive infinite null power notch filter at selected frequencies. The algorithm was used for elimination of higher harmonics 5, 7, 11, 13, 17, 19 from the input utility currents.
Dibenztroponeacetic and- propionic acids. Potent new antiinflammatory agents (1977)

The syntheses and antiinflammatory assays of some dibenztroponeacetic and -propionic acids and derivatives are described. The most potent compound, d-2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)propionic acid, has a potency of ca, 70 times phenylbutazone in the rat carrageenan paw assay and two to three times indomethacin in long-term animal assays. Some beta-dialkylaminoethyl esters of this compound also show high antiinflammatory activity.
Role of programmed death-1(PD-1) in patients with aplastic anemia (2009)

Objective To study the levels of programmed death-1(PD-1) and soluble PD-1(sPD-1) in peripheral blood of patients with aplastic anemia (AA) and explore their role in developing AA. Methods The expressions of PD-1 and sPD-1 were detected by flow cytometry in patients and healthy volunteers as the controls. Results The expression of sPD-1 in AA patients was significantly higher than that in the controls(P0.05),but AA patients had no expression of PD-1. Conclusion PD-1 falls off from the activated lymphocyte membrane,which leads to sPD-1 overexpression and absent expression of PD-1 in AA patients.Constent activation of T cells may cause dysfunction of marrow hemopoiesis.
A method for evaluating the impact of software configuration parameters on e-commerce sites (2005)

E-commerce systems are composed of many components with several configurable software parameters which, if properly configured, can optimize system performance. The cost and burden of implementing upgrades can be deferred by judicial tuning of these parameters. Tuning is a time consuming effort and energy has to be spent on the most relevant parameters. This paper provides a method to evaluate the statistical significance of configurable parameters in e-commerce systems, the interaction effects between each parameter and e-commerce function types, and a method to rank key configurable e-commerce system parameters that significantly impact overall system performance, and the performance of the most significant Web function types. Both on-line and off-line parameters at each of the e-commerce system layers---Web server, application server, and database server---are considered. The paper discusses the design of a practical and ad-hoc approach that involves conducting experiments on an e-commerce site compliant with the TPC-W benchmark. The performance metrics of interest include server's response time, system throughput, and probability of rejecting a customer's request. The paper also provides a set of useful guidelines for tuning the performance of e-commerce sites.
Biological Significance of Human Endogenous Retroviral Sequences (1996)

Endogenous retroviruses (ERVs) have been known for many years to exist in numerous natural and laboratory animal species. In humans it has been demonstrated that at least 1% of the genome consists of retrovirus-related sequences. Involvement of ERVs in the development of neoplastic and autoimmune diseases in the mouse model implicated a potentially pathogenic role of ERVs for humans, too. The research in this field led to a number of results strongly suggesting that human endogenous retroviral sequences (HERVs) are biologically active, on the RNA and even on the protein level. Particle formation, regulation or dysregulation of cellular gene expression, and synthesis of potentially pathogenic viral proteins indicate the broad spectrum of mechanisms by which HERVs may obtain biological significance.
Effects of oral magnesium supplementation on glycaemic control in Type 2 diabetes: a meta‐analysis of randomized double‐blind controlled trials (2006)

Oral magnesium supplementation for 4-16 weeks may be effective in reducing plasma fasting glucose levels and raising HDL cholesterol in patients with Type 2 diabetes, although the long-term benefits and safety of magnesium treatment on glycaemic control remain to be determined.
Stem Cell Bioprinting: Functional 3D Neural Mini‐Tissues from Printed Gel‐Based Bioink and Human Neural Stem Cells (Adv. Healthcare Mater. 12/2016) (2016)

On page 1429 G. G. Wallace, J. M. Crook, and co-workers report the first example of fabricating neural tissue by 3D bioprinting human neural stem cells. A novel polysaccharide based bioink preserves stem cell viability and function within the printed construct, enabling self-renewal and differentiation to neurons and supporting neuroglia. Neurons are predominantly GABAergic, establish networks, are spontaneously active, and show a bicuculline induced increased calcium response.
PR-143—A New Class of High-Temperature Fluids (1966)

A new class of high-temperature fluids, designated PR-143, which are capable of use in the range of −50 to −700 F, is discussed. These fluorinated materials do not sludge or tar on high-temperature exposure, even in the presence of air. The fluids are being tested in hydraulic systems, as gas turbine engine oils and as base fluids for high-temperature greases (designated PR-240). Properties and test results related to these applications are given.
Brd4 and HEXIM1: Multiple Roles in P-TEFb Regulation and Cancer (2014)

Bromodomain-containing protein 4 (Brd4) and hexamethylene bisacetamide (HMBA) inducible protein 1 (HEXIM1) are two opposing regulators of the positive transcription elongation factor b (P-TEFb), which is the master modulator of RNA polymerase II during transcriptional elongation. While Brd4 recruits P-TEFb to promoter-proximal chromatins to activate transcription, HEXIM1 sequesters P-TEFb into an inactive complex containing the 7SK small nuclear RNA. Besides regulating P-TEFb's transcriptional activity, recent evidence demonstrates that both Brd4 and HEXIM1 also play novel roles in cell cycle progression and tumorigenesis. Here we will discuss the current knowledge on Brd4 and HEXIM1 and their implication as novel therapeutic options against cancer.
A codeword-based indexing scheme for fingerprint identification (2008)

Fingerprint authentication system is now one of the most reliable personal identification methods. However, it is difficult to design a system such that it satisfies requirements in both accuracy and lookup speed due to large fingerprint database and complicated fingerprint measures. Therefore, fast and accurate fingerprint indexing plays very important role in fingerprint authentication system. In this paper, we present a new approach which is able to improve the performance of fingerprint indexing process. Moreover, this technique itself provides privacy property for fingerprint system which is not mentioned in previous indexing techniques.
Plant Regeneration from Tissue Cultures of Maize<sup>1</sup> (1975)

Abstract Effective utilization of cell and tissue culture methods in Zea mays research requires cultures capable of plant regeneration. These differentiated plants would provide a direct link with conventional genetic and breeding procedures. Maize callus from embryo scutellar tissues was initiated and maintained on MS medium inorganic components, Straus medium vitamins and amino acids, 20 g sucrose and 8 g agar per liter, and 2 mg 2,4‐dichlorophenoxyacetic acid (2,4‐D)/liter. Callus has been maintained subculture every 21 to 28 days and has remained capable of differentiation for 9 months. Regeneration of complete plants was accomplished by subculture of callus to 0.25 mg 2,4‐D/liter for 30 days followed by transfer to 2,4‐D‐free culture medium. At 0.25 mg 2,4‐D/liter numerous curled and wrinkled leaves developed. Approximately 200 complete plants have been differentiated. after transfer to the 2,4‐D‐free medium. Root tip cells from five plants indicated that each had 20 chromosomes. After transplantation to soil, 10 to 15% of the plants survived and grew normally. The optimum embryo age for scutellar callus initiation was 18 days post‐pollination. Hormone combinations such as 1 mg 2,4‐D, 4 mg a‐naphthaleneacetic acid (NAA), and 0.05 mg 6‐(γ,γ‐dimethyl allylamino)‐purine (2iP)/liter may increase the efficiency of scutellar callus initiation.
Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles (2015)

Metallo-β-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution of variant MBLs. The Verona integron-borne metallo-β-lactamase (VIM) enzymes are among the most widely distributed MBLs, with >40 VIM variants having been reported. We report on the crystallographic analysis of VIM-5 and comparison of biochemical and biophysical properties of VIM-1, VIM-2, VIM-4, VIM-5, and VIM-38. Recombinant VIM variants were produced and purified, and their secondary structure and thermal stabilities were investigated by circular dichroism analyses. Steady-state kinetic analyses with a representative panel of β-lactam substrates were carried out to compare the catalytic efficiencies of the VIM variants. Furthermore, a set of metalloenzyme inhibitors were screened to compare their effects on the different VIM variants. The results reveal only small variations in the kinetic parameters of the VIM variants but substantial differences in their thermal stabilities and inhibition profiles. Overall, these results support the proposal that protein stability may be a factor in MBL evolution and highlight the importance of screening MBL variants during inhibitor development programs.
Instrument To Detect Near-Infrared Fluorescence in Solid-Phase Immunoassay (1994)

The construction of a near-infrared (near-IR) fluorescence detector for measuring picomolar levels of near-IR laser dyes is described. The detector is designed for use in an immunoassay technique that employs antibodies labeled with near-IR polymethine cyanine dyes. These dyes possess spectral properties that are exclusive to the near-IR region (650-1100 nm). The instrumentation is characterized, including its hardware and data acquisition software components. The detector is capable of measuring fluorescence in both solution and solid-phase environments. Data on the detector's performance is presented.
Analysis of multiple wavelength DFB fiber lasers (2001)

The behavior of multiwavelength distributed feedback fiber lasers is simulated in a comprehensive numerical model. Multiple fundamental modes can coexist, even though the coupling coefficients of their respective refractive index gratings are not equal, due to induced dynamic gain gratings. We have investigated the effect on the lasing state of variations in coupling strengths, gain parameters, grating Bragg frequency separation, relative phase between the gratings, length of the structure relative to the beat lengths between the gratings, grating center phase-shift errors, and saturation level of the UV-induced refractive index change.
FURTHER STUDIES ON THE SUPPRESSING EFFECT OF ISOPROTERENOL ON THE IMMOBILITY-REDUCING ACTION OF DESIPRAMINE IN THE FORCED SWIMMING TEST (1983)

The present study was undertaken to examine whether the suppressing effect of intracerebroventricular (i.c.v.) administration of isoproterenol (ISO) on the immobility-reducing action of desipramine (DMI) in the forced swimming test was mediated through the presynaptic noradrenaline (NA) neurons and presynaptic α2-adrenoceptors in rat brain. As in the case of DMI, phenylephrine (i.c.v.) and yohimbine (i.p.) reduced the duration of immobility. The actions of DMI and yohimbine but not that of phenylephrine were diminished and potentiated by i.c.v. administration of ISO and atenolol, respectively. The suppressing effects of ISO were almost completely blocked by the pretreatment with atenolol. On the other hand, Clonidine (s.c.) diminished the action of DMI as did ISO, although Clonidine had no effect on the duration of immobility when given alone. The suppressing effect of Clonidine was antagonized by the pretreatment with yohimbine at a dose which did not affect the duration of immobility, when given alone, nor influenced the action of DMI, whereas the effect of ISO was not affected by the same dose of yohimbine. These results suggest that the suppressing effect of ISO on the immobility-reducing action of DMI in the forced swimming test is mediated through the presynaptic NA neurons, and ISO acts through the presynaptic β1- but not α2-adrenoceptors.