gebhart/patrepeval huggingface dataset:
Role of Steroid Receptor Coactivators in Glucocorticoid and Transforming Growth Factor β Regulation of Plasminogen Activator Inhibitor Gene Expression (2006)

TGFbeta is a major regulator of extracellular matrix deposition and a potent inducer of type-1 plasminogen activator inhibitor (PAI-1) gene expression. We have reported that liganded glucocorticoid receptor (GR) represses TGFbeta transactivation of PAI-1 in Hep3B human hepatoma cells and that it interacts functionally and physically with the C-terminal activation domain of Smad3, a mediator of TGFbeta signaling. The ligand binding domain of GR is required for GR-mediated transrepression, but the GR DNA binding domain and activation function 1 domains are not. We report here that overexpression of steroid receptor coactivator-1 (SRC-1) and GR-interacting protein-1 (GRIP-1) enhanced repression by liganded GR, and by a GR mutant defective in repression. Surprisingly, SRC-1 and GRIP-1 also enhanced TGFbeta-induced activation from the TGFbeta-responsive sequence of the PAI-1 gene by a GR-independent mechanism. Coimmunoprecipitation and mammalian one-hybrid experiments demonstrated that SRC-1 and GRIP-1 interact physically with endogenous Smad3 and functionally with the C-terminal domain of Smad3 to directly enhance transcription. Thus, the GR coactivators, SRC-1 and GRIP-1, act as both corepressors of the glucocorticoid repression of PAI-1 gene transcription, and coactivators of TGFbeta-induced activation of the PAI-1 promoter.
Zur Theorie der Glow-Kurven (1958)

Es wird der energetische Abstand einer Hafttermgruppe vom Leitungsband aus Glow-Kurven-untersuchungen unter der Annahme eines intensiven Retrappings berechnet. Der erhaltene Ausdruck wird mit bekannten Beziehungen verglichen. Es zeigt sich, daß die Bestimmung des Frequenzfaktors für die thermische Anregung von Elektronen aus Haftstellen einen Hinweis für die Größe des Retrappings liefert.
Improving Social Policy with National Data: A Comparison of Social Support for Students Among Canadian Provinces (2002)

Abstract: The purpose of this study was to examine social support for students as it related to individual and provincial characteristics in Canada, with data from the National Longitudinal Survey of Children and Youth and census data. The data included 7,648 students aged 8 to 11 years from 10 provinces. Factor analysis indicated two latent factors underlining social support for students: perceived personal support and perceived institutional support. Results of hierarchical linear modelling show that perceived personal support did not fluctuate with provincial characteristics. Students who were immigrants to Canada, with low socioeconomic status (SES), and with poor prosocial behavior perceived less personal support. Students in provinces with higher birth rates perceived less institutional support. SES and family size had strong effects on perceived institutional support in some provinces but weak effects in other provinces. Students from both-parent households, with emotional problems, and from large families perceived less institutional support.
A Male Sterile (ms-2) Gene in ‘California Wonder’ Pepper (Capsicum annuum L.)1 (1972)

Abstract A stable, male-sterile, recessive mutant designated ms-2 has been isolated from ‘California Wonder’ pepper and appears useful for hybrid production of Bell pepper types.
Attenuation regulation in the thr operon of Escherichia coli K-12: molecular cloning and transcription of the controlling region (1982)

Recombinant plasmids were constructed which carry defined regions of the threonine (thr) operon regulatory region of Escherichia coli. In vitro transcription experiments utilizing plasmid or restriction fragment templates showed that two major RNA transcripts, which differ in length by one to a few bases, are transcribed from this region. The approximate length of the transcripts is 150 to 170 bases, and the site(s) of termination is near or within the thr attenuator. The efficiency of termination at the thr operon attenuator in vitro is approximately 90%. A regulatory mutation, thr79-20, which is a G-C insertion in the attenuator, reduces the frequency of transcription termination to 75%. In addition, in vivo RNA transcripts were identified which hybridize to the thr operon regulatory region. These transcripts appeared to be identical to the two major in vitro transcripts as judged by their mobilities on 8% polyacrylamide-8 M urea gels. This result indicates that the thr operon regulatory region is transcribed in vivo and that termination occurs near or within the thr attenuator.
A framework for plan execution in behavior-based robots (2002)

We present a conceptual architecture for autonomous robots that integrates behavior-based and goal-directed action as by following a traditional action plan. Dual dynamics is the formalism for describing behavior-based action. Partial-order propositional plans are used as a basis for acting goal-directedly; the concept is suitable for using other planning methods and plan formats, though. We describe the corresponding action and plan representations at the plan side and at the behavior side. Moreover, we demonstrate how behavior-based action is biased towards executing a plan and how information from the behavior side is fed back to the plan side to determine progress in the plan execution.
Association of vitamin E and C supplement use with cognitive function and dementia in elderly men (2000)

These results suggest that vitamin E and C supplements may protect against vascular dementia and may improve cognitive function in late life.
A Comparison of Four Monte Carlo Methods for Estimating the Probability of s-t Connectedness (1986)

This paper describes and compares the performance of four alternative Monte Carlo sampling plans for estimating the probability that two nodes, s and t, are connected in an undirected network whose arcs fail randomly and independently. Models of this type are commonly used when computing the reliability of a system of randomly failing components. The first method, dagger sampling, relies for its advantage on inducing negative correlation between the outcomes of the replications in the sample. The second method, sequential destruction/construction exploits permutation properties of arc failures and successes. The third method uses easily determined bounds on the reliability probability to gain an advantage. The fourth approach enumerates all failure sets of the network to achieve its appeal. An example based on a 30-arc 20-node network illustrates the variance reducing features and the time and space needs of each sampling plan. Dagger sampling and sequential construction offer limited benefits when compared to the bounds and failure-sets methods. The failure-sets method performs best on the example for small failure probabilities. However, in general it offers no guarantee of a smaller variance than crude Monte Carlo and requires substantially more memory than the other methods. Moreover, this memory requirement can grow rapidly as the size of the network increases. By contrast, the bounds method guarantees a smaller variance than for crude Monte Carlo sampling and has modest memory requirements.
LazyCtrl: A Scalable Hybrid Network Control Plane Design for Cloud Data Centers (2016)

The advent of software defined networking enables flexible, reliable and feature-rich control planes for data center networks. However, the tight coupling of centralized control and complete visibility leads to a wide range of issues among which scalability has risen to prominence due to the excessive workload on the central controller. By analyzing the traffic patterns from a couple of production data centers, we observe that data center traffic is usually highly skewed and thus edge switches can be clustered into a set of communication-intensive groups according to traffic locality. Motivated by this observation, we present LazyCtrl, a novel hybrid control plane design for data center networks where network control is carried out by distributed control mechanisms inside independent groups of switches while complemented with a global controller. LazyCtrl aims at bringing laziness to the global controller by dynamically devolving most of the control tasks to independent switch groups to process frequent intra-group events near the datapath while handling rare inter-group or other specified events by the controller. We implement LazyCtrl and build a prototype based on Open vSwitch and Floodlight. Trace-driven experiments on our prototype show that an effective switch grouping is easy to maintain in multi-tenant clouds and the central controller can be significantly shielded by staying “lazy”, with its workload reduced by up to 82 percent.
Symmetry characteristics of the genetic code. (1982)

The symmetric pattern of codon degeneracies is discussed by using empirical arguments processed within a group-theoretic framework. It is reasoned that the genetic code is a relation rather than a mapping, and the symmetry of a relation defined on the codons is investigated. The principal results are (i) a new extraction of the basic symmetry inherent in the standard genetic code; (ii) the unification of the symmetry of ambiguous codon assignments with that of the standard genetic code; and (iii) the primacy of the concept of a biological context as that device which degenerates the code relation to a mapping.
Analysis environment of conversational structure with nonverbal multimodal data (2010)

This paper shows the IMADE (Interaction Measurement, Analysis, and Design Environment) project to build a recording and anlyzing environment of human conversational interactions. The IMADE room is designed to record audio/visual, human-motion, eye gazing data for building interaction corpus mainly focusing on understanding of human nonverbal behaviors. In this paper, we show the notion of interaction corpus and iCorpusStudio, software environment for browsing and analyzing the interaction corpus. We also present a preliminary experiment on multiparty conversations.
Optimization of Surface Wave Identification and Measurement (2001)

Accurate and reliable measurement of surface waves is important to Comprehensive Nuclear-Test-Ban Treaty (CTBT) monitoring because the M s :m b , discriminant and its regional variants can in many cases unambiguously identify events as earthquakes or explosions. Surface wave processing at the International Data Center (IDC) is designed to be completely automated and is performed using the program Maxsurf. Maxsurf searches for surface wave characteristics in the expected surface wave arrival time window for all continuous long-period and broadband data in the IDC processing stream. The Prototype IDC GSETT3 Reviewed Event Bulletin (REB) now contains a very large and growing data set of surface wave measurements. Users of this data set need to be aware of processing changes and calibration errors in the GSETT3 experimental bulletin. The prototype International Monitoring System (IMS) surface wave detection threshold is approximately one magnitude unit lower than the detection threshold of other global networks that use visual identification of surface waves. Surface wave identification and measurement can be improved through development of regionalized earth models, phase-matched filtering and the use of path corrected spectral magnitudes in place of M s . Regionalized earth models are developed through tomographic inversion of a very large data set of phase and group velocity dispersion measurements. Discrimination capability can be improved through the use of maximum likelihood magnitudes and maximum likelihood upper bounds.
LOW-MOLECULAR-WEIGHT METABOLITES RELEVANT TO ETHANOL METABOLISM: CORRELATION WITH ALCOHOL WITHDRAWAL SEVERITY AND UTILITY FOR IDENTIFICATION OF ALCOHOLICS (1997)

The blood levels of ethanol, acetaldehyde, acetate, methanol, acetone, lactate, pyruvate, and glucose were measured in 23 male alcohol-dependent patients on days 2 to 6 after hospitalization and in 22 healthy male blood donors. Correlations between the biochemical parameters and 17 symptoms of the alcohol-withdrawal syndrome (AWS) were calculated. Abnormally high levels of ethanol, methanol, acetate, and acetone as well as hypoglycaemia were found on day 2, but lactacidaemia and pyruvataemia were pronounced throughout the observation period. AWS severity correlated positively with the acetone content on day 2 and with the acetate content on days 2 to 6. Negative correlations were found between ethanol levels and craving for alcohol, methanol levels and craving for alcohol, and between psychopathologic disorders and the total AWS severity score. The results suggest that concentrations of blood ethanol, methanol, acetate, and acetone exceeding their normal endogenous levels can be used only as indicators of recent heavy drinking. Linear discriminant analysis using the levels of the nine parameters studied enabled the correct classification of 91% to 96% of alcoholic patients during 1 week of abstinence and 100% of control subjects. The most informative parameters in the discrimination between alcoholics and controls were lactate, pyruvate, the lactate/pyruvate ratio, acetate, and acetone.
Acute Pancreatitis (2006)

Acute pancreatitis (AP) is characterized by edema, acinar cell necrosis, hemorrhage, and severe inflammation of the pancreas. Patients with AP present with elevated blood and urine levels of pancreatic digestive enzymes, such as amylase and lipase. Severe AP may lead to systemic inflammatory response syndrome and multiorgan dysfunction syndrome, which account for the high mortality rate of AP. Although most (>80%) cases of AP are associated with gallstones and alcoholism, some are idiopathic. Although the pathogenesis of AP has not yet been elucidated, a common feature is the premature activation of trypsinogen within pancreatic tissues, which triggers autodigestion of the gland. Recent advances in basic research suggest that etiologic factors including cyclooxygenase-2, substance P, and angiotensin II may have novel roles in this disease. Basic research data obtained thus far have been based on animal models of AP ranging from mild edematous pancreatitis to severe necrotizing pancreatitis. In view of this, an adequate selection of experimental animal models is of paramount importance. Notwithstanding these animal models, it should be emphasized that none of these models mimic the clinical situation where varying degrees of severity usually occur. In this review, commonly used animal models of AP will be critically evaluated. A discussion of recent advances in our knowledge about AP risk factors is also included.
Nicotine intake by snuff users. (1981)

Blood nicotine and cotinine concentrations were measured in 27 volunteers before and after taking snuff. Within 10 minutes after snuffing blood nicotine concentrations were comparable to those obtained after the 10 minutes or so that it takes to smoke a cigarette. Nicotine intake from snuffing was related to the experience of the snuffer. In daily and occasional snuffers increases in plasma nicotine concentrations averaged 77.7 and 12.3 nmol/l (12.6 and 2.0 ng/ml) respectively, while the novices showed no appreciable increase. The increase shown by thea daily snuffers was comparable to the average increase of 62.3 nmol/l (10.1 ng/ml) obtained from a single cigarette by a group of heavy smokers. The peak nicotine concentrations in the daily snuffers were also similar to the peak values in 136 heavy smokers--222.6 and 226-3 nmol/l (36.1 and 36.7 ng/ml), respectively. Unusual multiple-dose snuffing produced massive increases in plasma nicotine to concentrations that have never been recorded in smokers. The similarity of the concentrations produced by regular daily snuffing and regular daily smoking suggests that the plasma nicotine concentration has some controlling influence over the self-regulation of these two quite different forms of tobacco use. The rapid absorption of nicotine from snuff confirms its potential as an acceptable and relatively harmless substitute for smoking.
<i>EGFR/KRAS/BRAF</i> Mutations in Primary Lung Adenocarcinomas and Corresponding Locoregional Lymph Node Metastases (2009)

The possibility of differences in the mutational status of EGFR, KRAS, BRAF between primary tumors and corresponding lymph node metastases should be considered whenever these mutations are used for the selection of patients for EGFR-directed tyrosine kinase inhibitor therapy.
Truncation of Herpes Simplex Virus Type 2 Glycoprotein B Increases Its Cell Surface Expression and Activity in Cell-Cell Fusion, but These Properties Are Unrelated (2002)

Formation of small polykaryons by cell-cell fusion is characteristic of herpes simplex virus (HSV) lesions, but the great majority of viruses isolated from such lesions produce only limited cell fusion in tissue culture. Because of this, HSV laboratory strains that produce extensive cell fusion (syncytium formation) in culture are regarded as variants or mutants. Furthermore, the rarity of clinical isolates able to produce syncytia in culture suggests that extensive cell fusion is deleterious in vivo. Mutations that confer a syncytial phenotype can then be regarded as bypassing a mechanism that normally limits cell fusion. Determination of how these mutations, some of which are in the cytoplasmic tail of glycoprotein B (gB), lead to syncytium formation will likely reveal how fusion is controlled. Here we show the following. (i) Truncation of the cytoplasmic tail of HSV type 2 gB (gB-2) by a minimum of 25 residues or a maximum of 49 residues produces a syncytial phenotype. (ii) Truncation by 20 to 49 residues increases cell fusion when gB-2 is coexpressed with only gD-2, gH-2, and gL-2. (iii) Truncation by 25 or more residues removes a potential endocytosis motif and increases gB-2 cell surface expression. (iv) Mutation of this motif increases gB-2 cell surface expression but does not increase fusogenic activity, whereas mutation of another potential endocytosis motif does not increase surface expression but does increase fusogenic activity. Therefore, syncytial mutations in the cytoplasmic tail of gB-2 do not act by increasing cell surface levels of the protein.
The diverse bacterial origins of the <i>Arabidopsis</i> polyamine biosynthetic pathway (2003)

We functionally identified the last remaining step in the plant polyamine biosynthetic pathway by expressing an Arabidopsis thaliana agmatine iminohydrolase cDNA in yeast. Inspection of the whole pathway suggests that the arginine decarboxylase, agmatine iminohydrolase, N-carbamoylputrescine amidohydrolase route to putrescine in plants was inherited from the cyanobacterial ancestor of the chloroplast. However, the rest of the pathway including ornithine decarboxylase and spermidine synthase was probably inherited from bacterial genes present in the original host cell, common ancestor of plants and animals, that acquired the cyanobacterial endosymbiont. An exception is S-adenosylmethionine decarboxylase, which may represent a eukaryote-specific enzyme form.
Emotional agents - state of the art and applications (2015)

last decade, intensive research on emotional intelligence has advanced significantly from its theoretical basis, analytical studies and processing technology to exploratory applications in a wide range of real-life domains. This paper brings new insights in the field of emotional, intelligent software agents. The first part is devoted to an overview of the state-of-the-art in emotional intelligence research with emphasis on emotional agents. A wide range of applications in different areas like modeling emotional agents, aspects of learning in emotional environments, interactive emotional systems and so on are presented. After that we suggest a systematic order of research steps with the idea of proposing an adequate framework for several possible real-life applications of emotional agents. We recognize that it is necessary to apply specific methods for dynamic data analysis in order to identify and discover new knowledge from available emotional information and data sets. The last part of the paper discusses research activities for designing an agent-based architecture, in which agents are capable of reasoning about and displaying some kind of emotions based on emotions detected in human speech, as well as online documents.
Chemoprevention by galanin against colon carcinogenesis induced by azoxymethane in wistar rats (1995)

The effects of the neuropeptide galanin on the development of colon tumors induced by azoxymethane (AOM) and on the labeling index of colon epithelial cells were investigated in Wistar rats. Treatment with galanin significantly decreased the incidence of colon tumors at week 45. Galanin did not influence the histological appearance of the colon tumors, but it slightly increased the frequency of sub-mucosal adenocarcinomas. Furthermore, it significantly decreased the labeling index of colon mucosa during and after AOM treatment. These findings indicate that galanin inhibited the development of colon tumors and that this effect may be related to its suppression of colon-epithelial-cell proliferation.
On calculating connected dominating set for efficient routing in ad hoc wireless networks (1999)

Efficient routing among a set of mobile hosts (also called nodes) is one of the most important functions in ad-hoc wireless networks. Routing based on a connected dominating set is a frequently used approach, where the searching space for a route is reduced to nodes in the set. A set is dominating if all the nodes in the system are either in the set or neighbors of nodes in the set. In this paper, we propose a simple and efficient distributed algorithm for calculating connected dominating set in ad-hoc wireless networks, where connections of nodes are determined by their geographical distances. Our simulation results show that the proposed approach outperforms a classical algorithm. Our approach can be potentially used in designing efficient routing algorithms based on a connected dominating set.
Sugar Acetates as Novel, Renewable CO<sub>2</sub>-philes (2002)

Acetylation of carbohydrates is proposed as a method for the synthesis of inexpensive CO2-philes that can easily be modified for a wide variety of green chemistry applications in liquid and supercritical CO2. The deliquescence of peracetylated sugars in contact with CO2 is reported in this communication as well as the unparalleled solubility of these compounds in supercritical CO2.
Benfotiamine in the treatment of diabetic polyneuropathy a three-week randomized, controlled pilot study (BEDIP Study) (2005)

This pilot investigation (BEDIP Study) has confirmed the results of two earlier randomized controlled trials and has provided further evidence for the beneficial effects of benfotiamine in patients with diabetic neuropathy.
RSU-Based Distributed Key Management (RDKM) For Secure Vehicular Multicast Communications (2011)

Although lots of research efforts have focused on group key management (GKM) for secure multicast, existing GKM schemes are inadequate for vehicle communication (VC) systems since they incur unnecessary rekeying overhead without considering the characteristics of VC systems such as Vehicle-to-Infrastructure communications and a great number of high mobility vehicles. Therefore, we propose a GKM scheme, called RSU-based decentralized key management (RDKM), dedicated for the multicast services in the VC systems. The RDKM scheme significantly reduces the rekeying overhead through delegating a part of the key management functions to the road-side infrastructure units (RSUs) and through updating the key encryption keys (KEKs) within a RSU. The performance of the RDKM scheme is analyzed in terms of communication overhead and storage overhead each of which has a strong impact on the performance of GKM. Furthermore, we propose an optimization algorithm that minimizes the weighted sum of the communication and the storage overhead, called the GKM overhead (GKMO), by appropriately determining the design parameters. The numerical results from the extensive analysis demonstrate that the RDKM scheme outperforms the existing GKM schemes in terms of the GKMO.