gebhart/patrepeval huggingface dataset:
Delivering Heparin-Binding Insulin-Like Growth Factor 1 with Self-Assembling Peptide Hydrogels (2014)

Heparin-binding insulin-like growth factor 1 (HB-IGF-1) is a fusion protein of IGF-1 with the HB domain of heparin-binding epidermal growth factor-like growth factor. A single dose of HB-IGF-1 has been shown to bind specifically to cartilage and to promote sustained upregulation of proteoglycan synthesis in cartilage explants. Achieving strong integration between native cartilage and tissue-engineered cartilage remains challenging. We hypothesize that if a growth factor delivered by the tissue engineering scaffold could stimulate enhanced matrix synthesis by both the cells within the scaffold and the adjacent native cartilage, integration could be enhanced. In this work, we investigated methods for adsorbing HB-IGF-1 to self-assembling peptide hydrogels to deliver the growth factor to encapsulated chondrocytes and cartilage explants cultured with growth factor-loaded hydrogels. We tested multiple methods for adsorbing HB-IGF-1 in self-assembling peptide hydrogels, including adsorption prior to peptide assembly, following peptide assembly, and with/without heparan sulfate (HS, a potential linker between peptide molecules and HB-IGF-1). We found that HB-IGF-1 and HS were retained in the peptide for all tested conditions. A subset of these conditions was then studied for their ability to stimulate increased matrix production by gel-encapsulated chondrocytes and by chondrocytes within adjacent native cartilage. Adsorbing HB-IGF-1 or IGF-1 prior to peptide assembly was found to stimulate increased sulfated glycosaminoglycan per DNA and hydroxyproline content of chondrocyte-seeded hydrogels compared with basal controls at day 10. Cartilage explants cultured adjacent to functionalized hydrogels had increased proteoglycan synthesis at day 10 when HB-IGF-1 was adsorbed, but not IGF-1. We conclude that delivery of HB-IGF-1 to focal defects in cartilage using self-assembling peptide hydrogels is a promising technique that could aid cartilage repair via enhanced matrix production and integration with native tissue.
Nuclear Factor I Isoforms Regulate Gene Expression During the Differentiation of Human Neural Progenitors to Astrocytes (2009)

Even though astrocytes are critical for both normal brain functions and the development and progression of neuropathological states, including neuroinflammation associated with neurodegenerative diseases, the mechanisms controlling gene expression during astrocyte differentiation are poorly understood. Thus far, several signaling pathways were shown to regulate astrocyte differentiation, including JAK-STAT, bone morphogenic protein-2/Smads, and Notch. More recently, a family of nuclear factor-1 (NFI-A, -B, -C, and -X) was implicated in the regulation of vertebral neocortex development, with NFI-A and -B controlling the onset of gliogenesis. Here, we developed an in vitro model of differentiation of stem cells towards neural progenitors (NP) and subsequently astrocytes. The transition from stem cells to progenitors was accompanied by an expected change in the expression profile of markers, including Sox-2, Musashi-1, and Oct4. Subsequently, generated astrocytes were characterized by proper morphology, increased glutamate uptake, and marker gene expression. We used this in vitro differentiation model to study the expression and functions of NFIs. Interestingly, stem cells expressed only background levels of NFIs, while differentiation to NP activated the expression of NFI-A. More importantly, NFI-X expression was induced during the later stages of differentiation towards astrocytes. In addition, NFI-X and -C were required for the expression of glial fibrillary acidic protein and secreted protein acidic and rich in cystein-like protein 1, which are the markers of astrocytes at the later stages of differentiation. We conclude that an expression program of NFIs is executed during the differentiation of astrocytes, with NFI-X and -C controlling the expression of astrocytic markers at late stages of differentiation.
<title>Current status of IR scene projection at the U.S. Army Aviation and Missile Command</title> (2001)

This paper describes the recent addition, characterization, and integration of emerging technologies for dynamic infrared scene projection at the US Army Aviation and Missile Command's Advanced Simulation Center. Infrared scene projection performs a vital role in the daily testing of tactical and theater missile systems within these Hardware- in-the-Loop (HWIL) laboratories. Topics covered within this paper include the addition and characterizations of new Honeywell and Santa Barbara Infrared emitter arrays, the integration and operation of the Honeywell and SBIR emitter array systems into a HWIL test, the development of high speed reduced-size IRSP drive electronics, the development of a NUC/characterization station, added software support, and the status of DMD-based infrared scene projector. Example imagery and test results from several of the projector systems are included within this paper.
STUDIES ON THE ANTI-TRICHOMONAL ACTINOMYCETES AND THEIR CLASSIFICATION (1955)

1. The mycological characters of 172 anti-trichomonal Actinomycetes, which had been selected from 1244 typical Actinomycetes, were studied, and their belonging 9 groups, 12 specics, and 3 new species is described. Among them the S. lavendulae, S. reticuli, S. diastatochromogenes, and S. griseus groups had large numbers of strains as shown in Table 1. However, some of the cultures of the S. diastatochromogenes group and the S. ruber group quickly lost their activity after repeated transfers on synthetic medium (Table 4).2. Morphologically these Actinomycetes may be divided into four sections, and, as shown in the text, further classified by using the color of the aerial mycelium, soluble pigment production, and the color of vegetative growth as keys.3. Strains H-5080, H-4871, and H-4650 were considered to be new species and were named S. purpeofuscus n. sp., S. naganishii n. sp., and S. griseoruber n. sp., respectively. 4. The antibiotic spectrum, the dilution potency, and the haemolytic power of these Actinomycetes were examined.5. Carbon utilization of typical anti-trichomonal Actinomycetes was studied (Table 3).
U.S. health care (1977)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious IssuesPublished Ahead-of-Print Collections Editorials of Laura Weiss Roberts, MD, MAAM Last PageCOVID-19 and Medical EducationAddressing Race and Racism in Medical EducationeBooksView All For Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor Permissions Journal Info About the JournalAbout the AAMCJournal MastheadSubmit a ManuscriptAdvertising InformationSubscription ServicesReprints and Back IssuesClassified AdsRights and PermissionsFor ReviewersFor MediaFor Trainees All Articles Images Videos Podcasts Blogs Advanced Search
Gastrointestinal function in chronic radiation enteritis--effects of loperamide-N-oxide. (1993)

The effects of loperamide-N-oxide, a new peripheral opiate agonist precursor, on gastrointestinal function were evaluated in 18 patients with diarrhoea caused by chronic radiation enteritis. Each patient was given, in double-blind randomised order, loperamide-N-oxide (3 mg orally twice daily) and placebo for 14 days, separated by a washout period of 14 days. Gastrointestinal symptoms; absorption of bile acid, vitamin B12, lactose, and fat; gastric emptying; small intestinal and whole gut transit; and intestinal permeability were measured during placebo and loperamide-N-oxide phases. Data were compared with those obtained in 18 normal subjects. In the patients, in addition to an increased frequency of bowel actions (p < 0.001), there was reduced bile acid absorption, (p < 0.001) a higher prevalence of lactose malabsorption (p < 0.05) associated with a reduced dietary intake of dairy products (p < 0.02), and faster small intestinal (p < 0.001) and whole gut transit (p < 0.05) when compared with the normal subjects. There was no significant difference in gastric emptying between the two groups. Treatment with loperamide-N-oxide was associated with a reduced frequency of bowel actions (p < 0.001), slower small intestinal (p < 0.001), and total gut transit (p < 0.01), more rapid gastric emptying (p < 0.01), improved absorption of bile acid (p < 0.01), and increased permeability to 51Cr EDTA (p < 0.01). These observations indicate that: (1) diarrhoea caused by chronic radiation enteritis is associated with more rapid intestinal transit and a high prevalence of bile acid and lactose malabsorption, and (2) loperamide-N-oxide slows small intestinal transit, increases bile acid absorption, and is effective in the treatment of diarrhoea associated with chronic radiation enteritis.
Multiple three‐dimensional mammalian cell aggregates formed away from solid substrata in ultrasound standing waves (2009)

Single and multiple three-dimensional cell aggregates of human red blood cells (RBCs) and HepG2 cells were formed rapidly in low mega-Hertz ultrasound standing wave fields of different geometries. A single discoid aggregate was formed in a half-wavelength pathlength resonator at a cell concentration sufficient to produce a 3D structure. Multiple cell aggregates were formed on the axis of a cylindrical resonator with a plane transducer (discoid aggregates); in a resonator with a tubular transducer and in the cross-fields of plane and tubular transducers and two plane orthogonal transducers (all cylindrical aggregates). Mechanically strong RBC aggregates were obtained by crosslinking with wheat germ agglutinin (WGA, a lectin). Scanning electron microscopy showed aggregate surface porous structures when RBCs were mixed with WGA before sonication and tighter packing when ultrasonically preformed aggregates were subsequently exposed to a flow containing WGA. HepG2 cell aggregates showed strong accumulation of F-actin at sites of cell-cell contact consistent with increased mechanical stability. The aggregates had a porous surface, and yet confocal microscopy revealed a tight packing of cells in the aggregate's inner core.
Polymer Chain Length Dependence of Amplified Fluorescence Quenching in Conjugated Polyelectrolytes (2008)

This paper reports the synthesis and photophysical study of a series of anionic, carboxylate-substituted poly(phenylene ethynylene)-based conjugated polyelectrolytes (CPEs) with variable chain lengths. These CPEs are of interest as they allow the study of the effect of chain length on amplified fluorescence quenching. The CPEs were synthesized via organic soluble ester precursor polymers. The degree of polymerization of the precursor polymers was controlled by addition of a monofunctional “end-cap” to the polymerization reaction. The CPEs were obtained postpolymerization by base-promoted hydrolysis of the ester protecting groups. Stern−Volmer fluorescence quenching of the CPEs in methanol with monovalent electron-transfer quenchers (MV+ and HV+) show that the Stern−Volmer quenching constant (KSV) increases with polymer chain length reaching a maximum of ca. 2 × 105 M−1 at a degree of polymerization of 49. The results indicate that a maximum quenching amplification factor of 53 is attained under conditions where monovalent quencher ions interact with nonaggregated (single) polymer chains.
Adaptive Lenses Based on Soft Electroactive Materials (2018)

Soft electroactive materials including dielectric elastomer actuators (DEAs) and polyvinyl chloride (PVC) gels have recently been extensively investigated. These smart materials can effectively respond to an electric field, resulting in shape deformation. In addition to artificial muscles, actuators, sensors, and micro-electromechanical systems, they can be used to prepare various adaptive lenses with unique features such as a simple fabrication, compact structure, good flexibility, and light weight. In contrast to DEAs, PVC gels can provide exciting opportunities for emerging applications in imaging, sensing, optical communication, biomedical engineering, and displays. In this review paper, the underlying physical mechanisms of these two electroactive materials are explained first, and then some recent progress in their application in macro-sized lenses and microlens arrays is presented. Finally, future perspectives of the PVC gels are discussed.
Lubricant as a Construction Element in the VDT Push-Belt CVT System (1993)

<div class="htmlview paragraph">Since 1987, Van Doorne's Transmissie (VDT) BV has produced a steel belt for continuously variable transmission (CVT) applications. To date, over 750,000 vehicles have been equipped with the system, and belt reliability has proved to be very high. During the early stages of transmission production, an intermittent lubricant-related noise problem was encountered. This paper describes the steps taken to isolate the noise source and eliminate it.</div> <div class="htmlview paragraph">The noise, commonly called the “scratch phenomenon,” manifests itself as a transfer-gear rattle under slow-speed, light-load conditions. Initial investigation revealed that the scratch phenomenon could be avoided by using an alternative transmission fluid (<span class="xref">1</span>). Experimental work conducted by Lubrizol and VDT to understand the mechanism behind the problem:</div> <div class="htmlview paragraph"> <ul class="list disc"> <li class="list-item"> <div class="htmlview paragraph">Established a relationship between the occurrence of the scratch phenomenon and the stick-slip properties of the belt-material/lubricant combination.</div> </li> <li class="list-item"> <div class="htmlview paragraph">Led to the development of a transmission test rig to replicate the conditions that produced the scratch phenomenon in the field.</div> </li> </ul> </div> <div class="htmlview paragraph">Simple screening tests then were developed to determine the potential of a fluid to produce the scratch phenomenon by evaluating its stick-slip characteristics. During this work, it was found that existing automatic transmission fluid (ATF) specifications did not necessarily contain performance requirements that describe a particular fluid's suitability for CVT applications. Additional work resulted in the development of a fluid designed specifically for CVTs, which eliminated the scratch phenomenon under all driving conditions and also provided superior wear protection under severe conditions (<span class="xref">2</span>).</div>
Brief exposure to small molecules allows induction of mouse embryonic fibroblasts into neural crest‐like precursors (2017)

In this study, we propose a novel method for inducing neuronal cells by briefly exposing them to small-molecule cocktails in a step-by-step manner. Global gene expression analysis with immunohistochemical staining and calcium flux assays reveal the generation of neurons from mouse embryonic fibroblasts. In addition, time-lapse imaging of neural precursor-specific enhancer expression and global gene expression analyses show that the neurons are generated by passing through a neural crest-like precursor stage. Consistent with these results, the neural crest-like cells are able to differentiate into neural crest lineage cells, such as sympathetic neurons, adipocytes, osteocytes, and smooth muscle cells. Therefore, these results indicate that brief exposure to chemical compounds could expand and induce a substantial multipotent cell population without viral transduction.
Supplementary List of South Carolina Words and Phrases (1954)

Research Article| April 01 1954 Supplementary List of South Carolina Words and Phrases F. W. Bradley F. W. Bradley University of South Carolina Search for other works by this author on: This Site Google Publication of the American Dialect Society (1954) 21 (1): 16–41. https://doi.org/10.1215/-21-1-16 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation F. W. Bradley; Supplementary List of South Carolina Words and Phrases. Publication of the American Dialect Society 1 April 1954; 21 (1): 16–41. doi: https://doi.org/10.1215/-21-1-16 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsAmerican Dialect SocietyThe Publication of the American Dialect Society Search Advanced Search The text of this article is only available as a PDF. American Dialect Society1954 Article PDF first page preview Close Modal You do not currently have access to this content.
Experiencia de cinco años en el uso del rFVIIa en pacientes con sangrado en el Centro Médico ABC. Una alternativa terapéutica (2011)

Antecedentes: Desde los anos 90 se descubrio y se introdujo en la practica clinica el rFVIIa (factor VII activado recombinante) para el manejo de pacientes hemofilicos con inhibidores de la coagulacion, obteniendo buenos resultados. Hasta el momento se ha descrito su empleo en reversion de anticoagulantes, cirugia y trauma, hepatopatia y trasplante hepatico, hemorragia cerebral no traumatica, trombocitopenia y disfuncion plaquetaria, con resultados favorables. Objetivo: Describir la experiencia de los primeros cinco anos (2005 a 2009) en el Centro Medico ABC con el uso del rFVIIa en pacientes con hemorragia aguda. Material y metodos: Estudio retrospectivo, descriptivo y observacional. Fueron incluidos los casos de pacientes que durante su estancia hospitalaria requirieron de la aplicacion del rFVIIa ademas de la dosis administrada y los hemocomponentes recibidos. Se analizo diagnostico, servicio clinico e indicacion para la administracion de rFVIIa, los tiempos de coagulacion y fibrinogeno antes y despues de la administracion del rFVIIa. Resultados: Se incluyeron 55 pacientes adultos no hemofilicos con edad promedio de 60 anos. Se sometieron a cirugia 47 enfermos. El servicio clinico que mostro mayor uso del rFVIIa fue el de Cirugia Cardiovascular. El 87.5% de los pacientes recibio mas de 10 hemocomponentes. El motivo de alta en el 75% de los casos fue mejoria. Fallecieron 14 pacientes, siete por coagulacion intravascular diseminada, tres por falla organica multiple, dos por choque septico, uno por choque cardiogenico y uno por trombosis mesenterica. Veintisiete pacientes presentaron coagulopatia antes de la aplicacion del rFVIIa con tiempo de protrombina (TP) de 27.4 segundos y tiempo de tromboplastina parcial activado (TTPa) de 88.8 segundos; se corrigio en 20 pacientes con TP de 14.3 segundos y TTPa 37.5 segundos. Conclusiones: La terapia con rFVIIa no es de primera linea en pacientes no hemofilicos con hemorragia aguda y siempre debe emplearse como terapia coadyuvante, bajo condiciones de estricta monitorizacion de pruebas de coagulacion in vitro. Una guia basada en evidencia disponible puede servir para sostener el adecuado empleo del rFVIIa y disminuir sustancialmente el abuso y los costos.
Magnetization Reversal in Thin Films (1955)

An experiment has been performed which indicates that magnetization reversal in evaporated films of 80 percent Ni, 20 percent Fe, 2\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}5}$ cm thick takes place by domain rotation rather than by the motion of 180\ifmmode^\circ\else\textdegree\fi{} domain walls.
Assured Deletion in the Cloud (2016)

Inadvertent exposure of sensitive data is a major concern for potential cloud customers. Much focus has been on other data leakage vectors, such as side channel attacks, while issues of data disposal and assured deletion have not received enough attention to date. However, data that is not properly destroyed may lead to unintended disclosures, in turn, resulting in heavy financial penalties and reputational damage. In non-cloud contexts, issues of incomplete deletion are well understood. To the best of our knowledge, to date, there has been no systematic analysis of assured deletion challenges in public clouds.
A unique virus complex causes <i>Ageratum</i> yellow vein disease (2000)

Ageratum conyzoides L., a weed species widely distributed throughout southeast Asia, frequently exhibits striking yellow vein symptoms associated with infection by Ageratum yellow vein virus (AYVV), a member of the Geminiviridae (genus Begomovirus). Most begomoviruses have bipartite genomes (DNAs A and B), but only a DNA A has been identified for AYVV. We demonstrate that yellow vein disease of A. conyzoides results from co-infection by AYVV DNA A (2,741 nt) and a circular DNA that is approximately half its size (1,347 nt) that we designate DNA beta. Apart from the sequence TAATATTAC, common to all geminiviruses and containing the initiation site of rolling circle replication, DNA beta shows negligible sequence homology either to AYVV DNA A or to DNA B associated with bipartite begomoviruses. DNA beta depends on DNA A for replication and is encapsidated by DNA A-encoded coat protein and so has characteristics of a DNA satellite. However, systemic infection of A. conyzoides by DNA A alone is sporadic and asymptomatic, and DNA A accumulation is reduced to 5% or less of its accumulation in the presence of DNA beta. Therefore, DNA A and DNA beta together form a previously unrecognized disease-inducing complex. Our data also demonstrate that the nanovirus-like DNA 1 component associated with infected A. conyzoides plays no essential role in the disease and represents a satellite-like DNA. Furthermore, the satellite DNA previously found associated with tomato leaf curl virus is probably a defective DNA beta homologue.
FLOW METERS FOR WATER RESOURCE MANAGEMENT<sup>1</sup> (1970)

ABSTRACT Regulated water flow is an essential feature of modern civilization. Effective use of water resources by industrial, agricultural, and municipal processes, as well as domestic conveniences, require controlled flow systems. Closely related to this regulation is the requirement for flow measurement, the techniques of which have developed over many centuries. Because of the relatively long history of flow metering and the multitude of improvements and new developments, a complete coverage of the subject is beyond the scope of this paper. Greater emphasis is placed on describing new developments and less conventional methods that are most usable for water resource applications and research studies, and less emphasis on older, generally familiar devices. Because of the diverse requirements in water measurement, few devices can be regarded as having no possible application. The selection of the most usable devices is somewhat arbitrary. Thus, at least passing mention will be made of most known devices for all fluids, and the reader guided to reference material for more complete coverage of a particular device or system.