gebhart/patrepeval huggingface dataset:
End-to-end Multi-Modal Multi-Task Vehicle Control for Self-Driving Cars with Visual Perceptions (2018)

Convolutional Neural Networks (CNN) have been successfully applied to autonomous driving tasks, many in an end-to-end manner. Previous end-to-end steering control methods take an image or an image sequence as the input and directly predict the steering angle with CNN. Although single task learning on steering angles has reported good performances, the steering angle alone is not sufficient for vehicle control. In this work, we propose a multi-task learning framework to predict the steering angle and speed control simultaneously in an end-to-end manner. Since it is nontrivial to predict accurate speed values with only visual inputs, we first propose a network to predict discrete speed commands and steering angles with image sequences. Moreover, we propose a multi-modal multi-task network to predict speed values and steering angles by taking previous feedback speeds and visual recordings as inputs. Experiments are conducted on the public Udacity dataset and a newly collected SAIC dataset. Results show that the proposed model predicts steering angles and speed values accurately. Furthermore, we improve the failure data synthesis methods to solve the problem of error accumulation in real road tests.
Leveraging big data to transform target selection and drug discovery (2015)

The advances of genomics, sequencing, and high throughput technologies have led to the creation of large volumes of diverse datasets for drug discovery. Analyzing these datasets to better understand disease and discover new drugs is becoming more common. Recent open data initiatives in basic and clinical research have dramatically increased the types of data available to the public. The past few years have witnessed successful use of big data in many sectors across the whole drug discovery pipeline. In this review, we will highlight the state of the art in leveraging big data to identify new targets, drug indications, and drug response biomarkers in this era of precision medicine.
CRMA: Incorporating Cut Redistribution With Mask Assignment to Enable the Fabrication of 1-D Gridded Design (2017)

1-D gridded design is one of the most promising solutions that can enable the scaling to 10 nm technology node and beyond. Line-end cuts are needed to fabricate 1-D layouts, where two techniques are available to resolve the conflicts between cuts: 1) cut redistribution and 2) cut mask assignment. In this paper, we consider incorporating the two techniques to enable the manufacturing of cut patterns in 1-D gridded design. We consider both 2-mask case (double patterning is performed on the cuts) and 3-mask case (triple patterning is performed on the cuts). We first present an accurate integer linear programming (ILP) formulation that can solve the co-optimization of cut redistribution and mask assignment optimally. In addition, we propose efficient graph-theoretic approaches based on a novel integrated graph model and a longest-path-based refinement algorithm. Experimental results demonstrate that our graphtheoretic approaches are orders of magnitude faster than the ILP-based method and meanwhile it can obtain very comparable results. For 2-mask case, comparing with the method that solves mask assignment and cut redistribution optimally but separately, our graph-theoretic approach that solves the two tasks simultaneously can achieve 95.0× smaller cost on average. We also extend our graph-theoretic approach to 3-mask case. Comparing with the method that reduces the 3-mask problem to 2-mask problem and solves it indirectly, our innovative approach that solves the problem directly based on a novel framework of identifying and solving 4-cliques can achieve 7.6% smaller cost on average.
Application of DNA Aptamers and Quantum Dots to Lateral Flow Test Strips for Detection of Foodborne Pathogens with Improved Sensitivity versus Colloidal Gold (2014)

Preliminary studies aimed at improving the sensitivity of foodborne pathogen detection via lateral flow (LF) test strips by use of high affinity DNA aptamers for capture and reporter functions when coupled to red-emitting quantum dots (Qdot 655) are reported. A variety of DNA aptamers developed against Escherichia coli, Listeria monocytogenes, and Salmonella enterica were paired in capture and reporter combinations to determine which yielded the strongest detection of their cognate bacteria using a colloidal gold screening system. Several promising sandwich combinations were identified for each of the three bacterial LF strip systems. The best E. coli aptamer-LF system was further studied and yielded a visible limit of detection (LOD) of ~3,000 E. coli 8739 and ~6,000 E. coli O157:H7 in buffer. These LODs were reduced to ~300-600 bacterial cells per test respectively by switching to a Qdot 655 aptamer-LF system. Novel aspects of these assays such as the use of high levels of detergents to avoid quantum dot agglutination and enhance migration in analytical membranes, identification of optimal analytical membrane types, UV-immobilization of capture aptamers, and novel dual biotin/digoxigenin-end labeled aptamer streptavidin-colloidal gold or -Qdot 655 conjugates plus anti-digoxigenin antibody control lines are also discussed. In general, this work provides proof-of-principle for highly sensitive aptamer-Qdot LF strip assays for rapid foodborne pathogen detection.
Etiology and Management of Whitening-induced Tooth Hypersensitivity (2007)

Tooth hypersensitivity has long been, and continues to be, the most commonly reported adverse effect of vital tooth whitening with peroxide gels. The complex etiology of whitening-induced tooth hypersensitivity has been a major obstacle in developing a definitive strategy for its prevention. This article reviews the multiple etiologic factors implicated in whitening-induced tooth hypersensitivity and the evidence for efficacy of various strategies for its management.
Modular Antigen‐Specific T‐cell Biofactories for Calibrated In Vivo Synthesis of Engineered Proteins (2018)

An artificial cell-signaling pathway is developed that capitalizes on the T-cell's innate extravasation ability and transforms it into a vector (<i>T-cell Biofactory</i>) for synthesizing calibrated amounts of engineered proteins in vivo. The modularity of this pathway enables reprogramming of the <i>T-cell Biofactory</i> to target biomarkers on different disease cells, e.g. cancer, viral infections, autoimmune disorders. It can be expected that the <i>T-cell Biofactory</i> leads to a "living drug" that extravasates to the disease sites, assesses the disease burden, synthesizes the calibrated amount of engineered therapeutic proteins upon stimulation by the diseased cells, and reduces targeting of normal cells.
Introducing natural thermoplastic shellac to microfluidics: A green fabrication method for point-of-care devices (2016)

We present a sustainable fabrication method for cheap point-of-care microfluidic systems, employing hot embossing of natural shellac as a key feature of an energy-efficient fabrication method that exclusively uses renewable materials as consumables. Shellac is a low-cost renewable biomaterial that features medium hydrophilicity (e.g., a water contact angle of ca. 73°) and a high chemical stability with respect to common solvents such as cyclohexane or toluene, rendering it an interesting candidate for low-cost microfluidics and a competitor to well-known systems such as paper-based or polydimethylsiloxane-based microfluidics. Moreover, its high replication accuracy for small features down to 30 μm lateral feature size and its ability to form smooth surfaces (surface roughness Ra = 29 nm) at low embossing temperatures (glass transition temperature Tg = 42.2 °C) enable energy-efficient hot embossing of microfluidic structures. Proof-of-concept for the implementation of shellac hot embossing as a green fabrication method for microfluidic systems is demonstrated through the successful fabrication of a microfluidic test setup and the assessment of its resource consumption.
The hybrid field-programmable architecture (1999)

The authors propose a new architecture that combines two existing technologies: lookup-table-based FPGAs and complex programmable logic devices based on PLA-like blocks. Their mapping results indicate that on average LUT-based FPGAs require 78% more area than their hybrid FPGA, while providing roughly the same circuit depth.
Effect of miR-142-3p on the M2 Macrophage and Therapeutic Efficacy Against Murine Glioblastoma (2014)

These data indicate a unique role of miR-142-3p in glioma immunity by modulating M2 macrophages through the transforming growth factor beta signaling pathway.
Development of bottom antireflective coating for high-resolution KrF lithography (2002)

There are considerable interests in the application of KrF lithographic process to achieve the beyond 0.13 micrometers resolution pattern. Decreasing in KrF resist thickness for high resolution in the lithographic process needs improvements of Bottom Anti-Reflective Coating (BARC) physical properties such as high etch selectivity and low reflectivity in thin KrF BARC film (350 ~ 400 Angstroms). It is known that the real and imaginary refractive indices of BARC are changed by film density and absorbance. Our research group have studied two different chromophore classes (BM1 and BM2) of functional groups that are highly absorptive at 248 nm and achieve high etch selectivity. Also, we have evaluated the effects of polymer structure on BARC in terms of refractive index changes and film density.
A multiple dose comparative study of the pharmacodynamic and pharmacokinetic behaviour of polymer‐matrix and Oros dosage forms of oxprenolol in healthy volunteers. (1985)

A new osmotic drug delivery system (Oros) has been evaluated in multiple-dose studies in young healthy volunteers as a sustained-release vehicle for once-daily administration of oxprenolol. Two Oros systems were examined in two separate studies, one containing 170 mg oxprenolol succinate with an initial zero-order release rate of 10 mg/h, and the other containing 260 mg oxprenolol succinate with an initial release rate of 16 mg/h. These were compared respectively with conventional oxprenolol hydrochloride (Trasicor) 80 mg twice daily and polymer-matrix oxprenolol hydrochloride (Slow Trasicor) 160 mg once daily. Variations in mean plasma levels and beta-adrenoceptor blockade (measured by inhibition of exercise tachycardia) were considerably reduced on the 10/170 Oros once-daily compared with the Trasicor 80 mg twice-daily regimen. With both formulations there was no significant change in mean plasma concentrations or areas under the curve after 8 days' treatment, and similar pre-dose plasma concentrations were obtained. There was significant inhibition of exercise tachycardia throughout 24 h after the 10/170 Oros on the eighth day. The 16/260 Oros system gave smoother pharmacokinetic and pharmacodynamic profiles, and on repeated dosing a higher mean pre-dose plasma oxprenolol concentration than Slow Trasicor. Drug availability was similar for the two dose forms, suggesting an acceptable level of absorption of oxprenolol from most of the gastrointestinal tract. On the eighth day exercise heart rate was significantly reduced throughout 24 h with 16/260 oxprenolol Oros, but only between 1 and 15 h with Slow Trasicor.
User Preference and Reliability of Bilateral Hearing Aid Gain Adjustments (2008)

The purpose of the current study was to evaluate the consistency and reliability of user adjustments to hearing aid gain and the resulting effects on speech understanding. Sixteen bilaterally aided individuals with hearing loss adjusted their hearing aid gain to optimize listening comfort and speech clarity while listening to speech in quiet and noisy backgrounds. Following these adjustments, participants readjusted their aids to optimize clarity and comfort while listening to speech in quiet. These final gain settings were recorded and compared to those provided by NAL-NL1 prescriptive targets. In addition, speech understanding was tested with the hearing aids set at target and user gain settings. Performance differences between the gain settings were then assessed. Study results revealed that although some listeners preferred more or less gain than prescribed, on average, user and prescribed gain settings were similar in both ears. Some individuals, however, made gain adjustments between ears resulting in "gain mismatches." These "mismatches" were often inconsistent across trials suggesting that these adjustments were unreliable. Speech testing results, however, showed no significant difference across the different gain settings suggesting that the gain deviations introduced in this study were not large enough to significantly affect speech understanding.
Synthesis, characterization, and hyperpolarizability measurements of main‐chain azobenzene molecules (2005)

Abstract A series of new AB type azobenzene monomers based on various substituted phenols and higher order fused/extended aromatic rings were synthesized and their hyperpolarizability tensor β determined by hyper‐Rayleigh scattering (HRS) measurement in methanol. The electron donor (OH) and acceptor units (COOH) were kept constant in the series, but the effective conjugation length was varied by varying the number and position of substituents as well as the number of aromatic rings. The effect of substitution of the phenolic ring on the β value was investigated and it was found to range from 15 × 10 −30 to 42 × 10 −30 esu. The effect of intramolecular hydrogen bonding on the nonlinear optical (NLO) property was also examined. The nonlinearity was in the following order of phenol derivative: α‐naphthol > phenyl phenol > 2,6‐dimethyl phenol > o ‐cresol > cardanol > phenol > β‐naphthol. The unusually low values for the β‐naphthol‐based chromophore compared with its isomer (α‐naphthol) could be rationalized based on hydrogen bonding of the o ‐hydroxyl group with the β nitrogen of the azo bridge. These azobenzene NLO chromophoric monomers were polymerized to form main‐chain polymers with a head to tail structure. The polymers had high thermal stability and rather low solubility in common organic solvents. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 4455–4468, 2005
Mechanisms of action of peptide inhibitors of mammalian ribonucleotide reductase targeting quaternary structure (2004)

Mammalian ribonucleotide reductase (mRR) is a chemotherapeutic target. The enzyme is composed of 2 subunits (mR1 and mR2) and is inhibited by Ac-FTLDADF (denoted P7), corresponding to the C-terminus of mR2, which competes with mR2 for binding to mR1. mRR has 2 physiologically important active forms, mR12mR22 and mR16(mR22)j (j = 1-3). Here we report on the mechanism of action of recently identified peptide derivatives having higher activities than P7 toward inhibition of one or both active forms. A significant feature of both P7 and these new inhibitors is that they are more potent vs. mR12mR22 than mR16(mR22)j. For some of these peptides, this is due in part to their preferential binding to the mR1 monomer. The possible application of these peptide derivatives in cancer chemotherapy is discussed.
The precipitation of poly‐<scp>L</scp>‐glutamic acid. II. β‐Precipitation (1975)

Abstract Infrared and X‐ray diffraction studies have established that in the β‐precipitation region of poly‐ L ‐glutamic acid the chains are in the β‐conformation. Therefore, a major molecular conformational change has taken place upon precipitation. It is shown that the size of the α‐helical aggregates remains constant with time in the β‐region. Strong evidence can be offered to indicate that the transformation involves a transitory random‐coil intermediate. Reasons are advanced, in view of the stability of the β‐form, as to why two distinct precipitation regions exist.
Initiation of the Degradation of the Soybean Kunitz and Bowman-Birk Trypsin Inhibitors by a Cysteine Protease (1991)

Protease K1 activity initiates the degradation of the Kunitz soybean trypsin inhibitor (KSTI) during germination and early seedling growth. This enzyme was purified nearly 1300-fold from the cotyledons of 4-day-old soybean (Glycine max [L.] Merrill) seedlings. Protease K1 is a cysteine protease with a molecular weight of approximately 29,000. It cleaves the native form of KSTI, Ti(a), to Ti(a) (m), the same modified form observed in vivo. In addition to attacking KSTI, protease K1 is also active toward the major Bowman-Birk soybean trypsin inhibitor, as well as the alpha, alpha', and beta subunits of soybean beta-conglycinin. The properties and temporal variation of protease K1 during germination indicate that it is responsible for initiating the degradation of both KSTI and Bowman-Birk soybean trypsin inhibitor in the soybean cotyledon.
Photodarkening and Photobrightening in Glasses Doped with CdS and CdS<sub>x</sub>Se<sub>1-x</sub> Nanocrystals (2000)

The photobrightening of photodarkened CdS- and CdS x Se 1- x -doped glasses has been investigated with luminescence experiments. Photobrightening depends on the wavelength of laser light, and is observed in all samples investigated, when the wavelength of laser light is longer than that of the absorption edge. Photobrightening is explained by considering the reexcitation of trapped electrons in glass.
Overriding of Access Control in XACML (2007)

Most access control mechanisms focus on how to define the rights of users in a precise way to prevent any violation of the access control policy of an organization. However, in many cases it is hard to predefine all access needs, or even to express them in machine readable form. One example of such a situation is an emergency case which may not be predictable and would be hard to express as a machine readable condition. Discretionary overriding of access control is one way for handling such hard to define and unanticipated situations where availability is critical. The override mechanism gives the subject of the access control policy the possibility to override a denied decision, and if the subject should confirm the override, the access will be logged for special auditing. XACML, the extensible access control markup language, provides a standardized access control policy language for expressing access control policies. This paper introduces a discretionary overriding mechanism in XACML. We do so by means of XACML obligations and also define a general obligation combining mechanism.
Attitude stabilization of a rigid spacecraft using two momentum wheel actuators (1995)

It is well known that three momentum wheel actuators can be used to control the attitude of a rigid spacecraft and that arbitrary reorientation maneuvers of the spacecraft can be accomplished using smooth feedback. If failure of one of the momentum wheel actuators occurs, it is demonstrated that two momentum wheel actuators can be used to control the attitude of a rigid spacecraft and that arbitrary reorientation maneuvers of the spacecraft can be accomplished. Although the complete spacecraft equations are not controllable, the spacecraft equations are small time locally controllable in a reduced nonlinear sense. The reduced spacecraft dynamics cannot be asymptotically stabilized to any equilibrium attitude using a time-variant continuous feedback control law, but discontinuous feedback control strategies are constructed which stabilize any equilibrium attitude of the spacecraft in finite time. Consequently, reorientation of the spacecraft can be accomplished using discontinuous feedback control.
Binding sites of pyrene and related compounds and chiral excimer formation in the cavities of cyclodextrins and branched cyclodextrins (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBinding sites of pyrene and related compounds and chiral excimer formation in the cavities of cyclodextrins and branched cyclodextrinsKoji. Kano, Hitoshi. Matsumoto, Yoshimichi. Yoshimura, and Shizunobu. HashimotoCite this: J. Am. Chem. Soc. 1988, 110, 1, 204–209Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ja00209a033https://doi.org/10.1021/ja00209a033research-articleACS PublicationsRequest reuse permissionsArticle Views486Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Atomic layer deposition of lanthanum aluminum oxide nano-laminates for electrical applications (2004)

Lanthanum aluminum oxide thin films were grown by atomic layer deposition from a lanthanum precursor, tris(N,N′-diisopropylacetamidinato)lanthanum (La(iPrAMD)3), trimethylaluminum and water. Smooth, amorphous films having compositions La0.5Al1.5O3 and La0.9Al1.1O3 were deposited on HF-last silicon and characterized without postdeposition annealing. The films contained less than 1 at. % of carbon according to Rutherford backstattering spectrometry and secondary ion mass spectrometry. A thin (9.8 nm) film showed low leakage current (&lt;5*10−8 A/cm2 at 1 V for an equivalent oxide thickness of 2.9 nm), flatband voltage of −0.1 V and low hysteresis (20 mV). Thicker films had even lower leakage currents (&lt;10−8 A/cm2 at 2 MV/cm) but larger flatband shifts and more hysteresis. The permittivity of the films was 13 and the dielectric strength 4 MV/cm. Cross sectional high-resolution transmission electron microscopy showed a sharp interface between the film and the silicon substrate.
Real-Time Radionuclide Cineangiography in the Noninvasive Evaluation of Global and Regional Left Ventricular Function at Rest and during Exercise in Patients with Coronary-Artery Disease (1977)

Although coronary angiography defines regions of potential ischemia in patients with coronary-artery disease, accurate assessment of the presence and functional importance of ischemia requires appraisal of regional and global left ventricular function during stress. To perform such assessment, we developed a noninvasive real-time radionuclide cineangiographic procedure permitting continuous monitoring and analysis of left ventricular function during exercise. In 11 patients with coronary disease who had normal regional and global ventricular function at rest, new regions of dysfunction developed during exercise (P less than 0.001), and in 10, global ejection fraction dropped 7 to 47 per cent. Fourteen age-matched normal subjects were studied; during exercise none had regional dysfunction, and each increased global ejection fraction (average increase, 23 +/- 3 per cent [+/-S.E.], P less than 0.001 as compared with patients with coronary disease). Radionuclide cineangiography during exercise permits accurate assessment of the presence and functional severity of ischemic heart disease.