gebhart/patrepeval huggingface dataset:
The osteoprotective effect of <i>Herba epimedii</i> (HEP) extract <i>in vivo</i> and <i>in vitro</i> (2005)

Herba epimedii (HEP) is one of the most frequently used herbs prescribed for treatment of osteoporosis in China. In the present study, the in vivo effects of HEP extract on bone metabolism were evaluated using 4-month-old ovariectomized (OVX) or sham-operated (Sham) female Sprague-Dawley rats orally administered with HEP extract (110 mg kgd), 17ss-estrogen (2 mg kgd) or its vehicle for 3 months. HEP extract significantly decreased urinary calcium excretion, suppressed serum alkaline phosphatase (ALP) activity and urinary deoxypyridinoline levels in OVX rats (P < 0.05 versus vehicle-treated OVX rats). Histomorphometric analysis indicated that HEP extract could prevent OVX-induced bone loss by increasing tibial trabecular bone area and decreasing trabecular separation in OVX rats (P < 0.05 versus vehicle-treated OVX group). The in vitro effects of HEP extract were also studied using rat osteoblast-like UMR 106 cells. HEP extract significantly stimulated cell proliferation in a dose-dependent manner (P < 0.01 versus vehicle-treated) and increased ALP activity at 200 microgml (P < 0.01 versus vehicle-treated) in UMR 106 cells. It modulated osteoclastogenesis by increasing osteoprotegrin (OPG) mRNA and decreasing receptor activator of NF-kappaB ligand (RANKL) mRNA expression, resulting in a dose-dependent increase in OPG/RANKL mRNA ratio (P < 0.01 versus vehicle-treated). Taken together, HEP treatment can effectively suppress the OVX-induced increase in bone turnover possibly by both an increase in osteoblastic activities and a decrease in osteoclastogenesis. The present study provides the evidence that HEP can be considered as a complementary and alternative medicine for treatment of post-menopausal osteoporosis.
Novel Strategy to Develop Exciplex Emitters for High‐Performance OLEDs by Employing Thermally Activated Delayed Fluorescence Materials (2016)

To develop high‐performance thermally activated delayed fluorescence (TADF) exciplex emitters, a novel strategy of introducing a single‐molecule TADF emitter as one of the constituting materials has been presented. Such a new type of exciplex TADF emitter will have two reverse intersystem crossing (RISC) routes on both the pristine TADF molecules and the exciplex emitters, benefiting the utilization of triplet excitons. Based on a newly designed and synthesized single‐molecule TADF emitter MAC, a highly efficient exciplex emitter MAC:PO‐T2T has been obtained. The device based on MAC:PO‐T2T with a weight ratio of 7:3 exhibits a low turn‐on voltage of 2.4 V, high maximum efficiency of 52.1 cd A −1 (current efficiency), 45.5 lm W −1 (power efficiency), and 17.8% (external quantum efficiency, EQE), as well as a high EQE of 12.3% at a luminance of 1000 cd m −2 . The device shows the best performance among reported organic light‐emitting devices based on exciplex emitters. Such high‐efficiency and low‐efficiency roll‐off should be ascribed to the additional reverse intersystem crossing process on the MAC molecules, showing the advantages of the strategy described in this study.
Moisture Pollution of the Atmosphere By Cooling Towers and Cooling Ponds (1970)

* Testimony presented on “Environmental Effects of Nuclear Power Installations in the Willamette Valley” before the Oregon Legislative Task Force on Pollution, 7 November 1969, at Eugene, Oreg.
OKT3 escalating dose regimens provide effective therapy for renal allograft rejection. (1996)

Dose-response relationships for anti-CD3 monoclonal antibody (mAb) therapy remain undefined, particularly with respect to higher dose ranges. The clinical efficacy and safety of an OKT3 dosing regimen that incorporates higher doses (escalating dose regimens) was examined in a pilot trial. Patients undergoing acute rejection were treated with a 7-d course of OKT3 in which the daily OKT3 dose was escalated during treatment course (daily doses 5, 5, 5, 5, 10, 15, 25 mg). The total amount of OKT3 given was equal to a standard 14-d course (70 mg). A total of 10 primary cadaveric renal transplant recipients were treated, and data analyzed from a median follow up of 5 months (range 3-13 months). Pre-OKT3 immunosuppressive therapy consisted of ATGAM induction therapy (n = 8), and corticosteroid rejection therapy (n = 6, 18.6 +/- 11.4 mg/kg). Median time of first rejection was 32 d (12-48 d) and median time to OKT3 was 33 d (range 15-42 d). Pre-OKT3 histology (by Banff criteria) included: mild ACR (n = 6), moderate ACR (n = 2), AVR (n = 1), ACR and acute transplant glomerulopathy (n = 1). Rejection reversal rate with escalating dose OKT3 was 100%, and each patient experienced a rapid reversal of rejection (i.e. reversal within 14 d initiation of OKT3 therapy). Six recurrent rejection episodes were diagnosed in 5 patients with a median time to recurrent rejection of 30 d following cessation of OKT3 therapy. All recurrent rejection episodes were successfully treated (FK 506 n = 4, corticosteroids n = 1, and OKT3 n = 1). CMV disease was limited to a single episode of CMV viremia in one patient. PTLD was observed in one patient who had coexisting vascular rejection at the time of PTLD diagnosis. Short- and long-term graft function is excellent (pre-rejection baseline creatinine 1.8 +/- 0.4 mg/dl, current creatinine 1.75 +/- 0.4 mg/dl). Monitoring of OKT3 serum levels revealed that patients maintained therapeutic serum levels for an average of 4 d following the last OKT3 dose. Circulating CD3+ and CD5+ cells were maintained below baseline levels for at least 10 d following the last OKT3 dose. Anti-OKT3 antibody formation occurred in 22% of patients, however, anti-idiotypic responses were of low titer. Adverse reactions experienced during dose escalation were minimal compared to first dose reactions, and consisted primarily of mild headaches and arthralgias in a minority of patients. OKT3 EDR, by obviating monitoring and administration costs, are cost effective [OKT3 EDR $8088, OKT3 SDR (10 d) $9684, OKT3 SDR (14 d) $13,224]. In conclusion, escalating dose regimens of OKT3: 1) provide rejection reversal rates similar to standard dose regimens, 2) provide high OKT3 serum levels and reliable CD3+ cell depletion, 3) induce minimal adverse reactions during dose escalation, and 4) may decrease costs by obviating the need for monitoring peripheral blood T cells and by decreasing administration costs and outpatient visits.
Detection of Bladder Cancer Using a Point-of-Care Proteomic Assay (2005)

The noninvasive point-of-care assay for elevated urinary NMP22 protein can increase the accuracy of cystoscopy, with test results available during the patient visit.
Temperature‐Restricted Mutants of Human Adenovirus Type 5 (1971)

This chapter contains section titled: Mutagenesis and Isolation of Mutants Mutant Stability Compliwentation Recombination Transformation By Adbnovirus Type5 Concluding Remarks Summary References Discussion Transformation With Adenovirus Type5 Reactivation, Complementation and Recombination References General Discussion Inhibition of Plaque Formation By Extracts Transcription in Transformed Cells References
Towards Mass Production of Smart Products by Forming Technologies (2014)

In all areas of technology, the demand for high-quality, competitive and more valuable products is rising steadily. One approach to increase the value of manufactured products is the integration of electronic components in load carrying structures. These new products, which combine electrical and mechanical components synergistically, are called smart products. They consist of a passive structure and integrated electronics or smart materials. In addition to their mechanical properties they are also able to sense, to actuate or to transmit energy or data. The resulting product architecture requires both a mechanical and an electronic design in order to save subsequent assembly costs. Since further components are required to evaluate and control as well as to supply energy, all of those components need to be connected and integrated into the smart product. However, the main prerequisite for the marketability is the possibility of low-cost manufacturing and a robust mass production. Nowadays processes for the manufacturing of smart products do not fulfill the requirements for a sustainable mass production in a satisfying way as long as metallic structures are used. The authors deploy the forming technologies roll forming and sheet metal hydroforming to form sheets with applied flat electronics. Since the components are applied prior to the forming process, small and difficult to access installation spaces can be used effectively in the product architecture. The incremental bulk forming process rotary swaging is employed to integrate piezoceramics during the forming procedure without any additional joining elements. Challenges resulting from the chosen integrative manufacturing approach are the prevention of new kinds of failure modes and additional requirements for defined residual stress states. These challenges lead to extended process design requirements, which will be discussed in the paper in detail.
Modeling sound-source localization in sagittal planes for human listeners (2014)

Monaural spectral features are important for human sound-source localization in sagittal planes, including front-back discrimination and elevation perception. These directional features result from the acoustic filtering of incoming sounds by the listener's morphology and are described by listener-specific head-related transfer functions (HRTFs). This article proposes a probabilistic, functional model of sagittal-plane localization that is based on human listeners' HRTFs. The model approximates spectral auditory processing, accounts for acoustic and non-acoustic listener specificity, allows for predictions beyond the median plane, and directly predicts psychoacoustic measures of localization performance. The predictive power of the listener-specific modeling approach was verified under various experimental conditions: The model predicted effects on localization performance of band limitation, spectral warping, non-individualized HRTFs, spectral resolution, spectral ripples, and high-frequency attenuation in speech. The functionalities of vital model components were evaluated and discussed in detail. Positive spectral gradient extraction, sensorimotor mapping, and binaural weighting of monaural spatial information were addressed in particular. Potential applications of the model include predictions of psychophysical effects, for instance, in the context of virtual acoustics or hearing assistive devices.
Ultra-high speed and ultra-high resolution spectral-domain optical coherence tomography and optical Doppler tomography in ophthalmology. (2006)

We present ultra-high resolution optical coherence tomography (OCT) structural intensity and optical Doppler tomography (ODT) flow velocity images of the human retina in vivo. The ultra-high speed OCT system is based on Spectral Domain or Fourier Domain technology, which provides a sensitivity advantage over conventional OCT of more than 2 orders of magnitude. This sensitivity improvement allows video rate OCT and ODT cross sectional imaging of retinal structures. Images will be presented with axial resolutions of 6 and 3.5 microns. We observed small features in the inner and outer plexiform layers, which are believed to be small blood vessels. Flow velocity images will be presented showing pulsatile flow in retinal arteries and veins.
A new topology for passive PFC circuit design to allow AC-to-DC converters to comply with the new version of IEC1000-3-2 regulations (2003)

The new edition of the IEC-1000-3-2 standard has led to the need for certain major concepts to once again come under the microscope for reconsideration. As the Class D template has disappeared, circuits designed to comply with the regulation by changing from Class D to Class A are now obsolete. The LC filter complies with the regulation in Class A with a very small inductance. To comply with Class D requirements a new circuit, which has been called a TLC rectifier, is proposed in this paper to reduce the passive device. The results obtained have been verified by computer simulation and experimental results.
Low cost reclamation using the Advanced Integrated Wastewater Pond Systems® Technology and reverse osmosis (2002)

The sustainability of wastewater reclamation and reuse schemes is often limited by the increase in salt concentration that occurs with each water use. In this pilot study, we show that the cost of reclaiming wastewater and removing salt can be dramatically decreased by integrating recent advances in wastewater pond design, solids separation equipment, and membrane technology. Effluent from an AIWPS Facility was clarified in a Krofta Supracell Dissolved Air Flotation (DAF) unit and a Slow Sand Filter (SSF) prior to final treatment in an Expertise S.r.l. reverse osmosis (RO) unit. The ponds of the AIWPS Facility removed an average of 82% of soluble BOD and 80% of soluble nitrogen. Following clarification, filtration, and RO treatment, the pollutant removals were > 99% for soluble BOD, > 99% for soluble nitrogen, and 98% for TDS. Based on membrane fouling rate data, the cleaning interval for the RO membranes in a full-scale AIWPS-RO Facility would be over 100 days. This interval is on par with that typically seen in full-scale reclamation facilities treating secondary activated sludge effluent with microfiltration prior to reverse osmosis. A 4-MLD AIWPS-RO Facility is expected to produce permeate water at substantially lower cost and lower energy consumption (US $698 and 443 kWh per million liters treated) than a system of equal capacity using conventional activated sludge secondary treatment followed by microfiltration and reverse osmosis (US $1274 and 911 kWh per million litres treated). This cost and energy differential is attributable to the lower capital and operating expenses of the AIWPS Technology in comparison with activated sludge.
Inhibition of intrinsic gap-junction intercellular communication and enhancement of tumorigenicity of the rat bladder carcinoma cell line BC31 by a dominant-negative connexin 43 mutant (1998)

The tumor-suppressive property of the connexin gap-junction proteins was postulated from the fact that their function of cell coupling is impaired in most cancer cells. However, in conflict with this notion, certain cancer cells are able to communicate through gap junctions despite their malignancy. To explain this phenomenon, we studied by using a dominant-negative strategy the effect on tumorigenicity of loss of intrinsic gap-junction intercellular communication (GJIC) in the rat bladder carcinoma cell line BC31, which shows both expression of connexin 43 (Cx43) and intercellular communication. In cells transfected with a mutant Cx43 with seven residues deleted from the internal loop at positions 130-136 (Cx43delta), transport of the resulting connexin protein to the plasma membrane occurred normally, but the GJIC of the cells was effectively abolished at the level of permeability of established gap junctions. Dominant-negative inhibition of GJIC by Cx43delta accelerated growth of BC31 cells in nude mice. In contrast, when GJIC in BC31 cells was artificially enforced by transfection of wild-type Cx43, the cells lost the capacity to grow in vivo. Decreased phosphorylation of Cx43delta suggested close interaction of the internal loop of connexin with its commonly phosphorylated domains in the C-terminal tail and involvement of this interaction in gap-junction permeability. Therefore, we conclude that the intrinsic GJIC observed in cancer cells should be considered a tumor-suppressor factor and that its level may influence malignant growth capacity.
Fascia Augmentation of the Vocal Fold: Graft Yield in the Canine and Preliminary Clinical Experience (2001)

Based on the animal study, we concluded that graft yields are excellent but variable for AFIA. The result is similar in variability and overall yield to autologous lipoinjection. Subjective and objective analyses of voice outcomes after AFIA are universally improved. Fascia appears to be an excellent alternative to lipoinjection in properly selected cases of glottic insufficiency.
Production and characterization of neutralizing monoclonal antibodies that recognize an epitope in domain 2 of<i>Bacillus anthracis</i>protective antigen (2006)

Antibodies against the protective antigen (PA) of Bacillus anthracis play a key role in response to infection by this important pathogen. The aim of this study was to produce and characterize monoclonal antibodies (mAbs) specific for PA and to identify novel neutralizing epitopes. Three murine mAbs with high specificity and nanomolar affinity for B. anthracis recombinant protective antigen (rPA) were produced and characterized. Western immunoblot analysis, coupled with epitope mapping using overlapping synthetic peptides, revealed that these mAbs recognize a linear epitope within domain 2 of rPA. Neutralization assays demonstrate that these mAbs effectively neutralize lethal toxin in vitro.
Mechanisms And Pathways Of Inflammatory Responses In Cns Trauma: Spinal Cord Injury (2002)

Numerous mechanisms contribute to neural damage following central nervous system (CNS) injury. Inflammatory response has emerged as an important interaction between the CNS and the immune system in spinal cord injury that can have beneficial as well as detrimental consequences. This relationship has important implications for the development of therapeutic interventions for injuries and diseases of the spinal cord. This article details the innate and adaptive arms of the immune response, including cell-mediated and humoral pathways, and describes their relevance to the processes of degeneration and regeneration.
Multi-Head Attention for Multi-Modal Joint Vehicle Motion Forecasting (2020)

This paper presents a novel vehicle motion forecasting method based on multi-head attention. It produces joint forecasts for all vehicles on a road scene as sequences of multi-modal probability density functions of their positions. Its architecture uses multi-head attention to account for interactions between all vehicles, and long short-term memory layers for encoding and forecasting. It relies solely on vehicle position tracks, does not need maneuver definitions, and does not rasterize the scene as a spatial grid. This allows it to be more versatile than similar model while combining many forecasting capabilities, namely joint forecast with interactions, uncertainty estimation, and multi-modality. The resulting prediction likelihood outperforms state-of-the-art models on the same dataset.
CUSTODES (2016)

Various techniques have been proposed to detect smells in spreadsheets, which are susceptible to errors. These techniques typically detect spreadsheet smells through a mechanism based on a fixed set of patterns or metric thresholds. Unlike conventional programs, tabulation styles vary greatly across spreadsheets. Smell detection based on fixed patterns or metric thresholds, which are insensitive to the varying tabulation styles, can miss many smells in one spreadsheet while reporting many spurious smells in another. In this paper, we propose CUSTODES to effectively cluster spreadsheet cells and detect smells in these clusters. The clustering mechanism can automatically adapt to the tabulation styles of each spreadsheet using strong and weak features. These strong and weak features capture the invariant and variant parts of tabulation styles, respectively. As smelly cells in a spreadsheet normally occur in minority, they can be mechanically detected as clusters' outliers in feature spaces. We implemented and applied CUSTODES to 70 spreadsheets files randomly sampled from the EUSES corpus. These spreadsheets contain 1,610 formula cell clusters. Experimental results confirmed that CUSTODES is effective. It successfully detected harmful smells that can induce computation anomalies in spreadsheets with an F-measure of 0.72, outperforming state-of-the-art techniques.
Intracavity Terahertz Generation in a Synchronously Pumped Optical Parametric Oscillator using Quaso-phasematched GaAs (2007)

We generated 1 mW of average power at 2.9 THz (540 GHz bandwidth) in a nearly- diffraction-limited beam by placing a room-temperature quasi-phasematched GaAs crystal inside the cavity of a synchronously pumped optical parametric oscillator.
Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines (2021)

The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each injection leading to more efficient immunization programs. The mRNA components of the vaccine need to have a 5'-UTR to load ribosomes efficiently onto the mRNA for translation initiation, optimized codon usage for efficient translation elongation, and optimal stop codon for efficient translation termination. Both 5'-UTR and the downstream 3'-UTR should be optimized for mRNA stability. The replacement of uridine by N1-methylpseudourinine (Ψ) complicates some of these optimization processes because Ψ is more versatile in wobbling than U. Different optimizations can conflict with each other, and compromises would need to be made. I highlight the similarities and differences between Pfizer/BioNTech and Moderna mRNA vaccines and discuss the advantage and disadvantage of each to facilitate future vaccine improvement. In particular, I point out a few optimizations in the design of the two mRNA vaccines that have not been performed properly.
Working with heat exchangers : questions and answers (1990)

Shell and tube heat exchangers augmented surface heat exchangers heat exchangers for special services plate and spiral plate heat exchangers heat exchanger dynamics and optimization codes and standards.
Constitutive Equations for Polymeric Liquids (1995)

The field of fluid mechanics is rapidly advancing, driven by unprecedented volumes of data from experiments, field measurements, and large-scale simulations at multiple spatiotemporal scales. Machine learning (ML) offers a wealth of techniques to extract ...Read More
Mathematic Modeling and Simulation for Aerodynamic Radiation Characteristics of Infrared Decoy (2008)

Infrared decoy has the most frequent application to infrared countermeasures in the world,and there is an immediate correlation between its aerodynamic characteristics and its infrared radiation characteristics.Mathematic models were built to describe the effect of aerodynamic characteristics on infrared imaging and unimaging.Firstly aerodynamic mathematic model of infrared decoy was built by applying the theories of hydromechanics and thermal conduction.Secondly equivalent molecule blackbody was proposed based on statistics,and a new calculation method for infrared radiation characteristics of hot gas was deduced by probability theory.Finally aerodynamic radiation characteristics of infrared decoy were simulated.The simulation results show correctness of the mathematic model.
Maintaining variance and k-medians over data stream windows (2003)

The sliding window model is useful for discounting stale data in data stream applications. In this model, data elements arrive continually and only the most recent N elements are used when answering queries. We present a novel technique for solving two important and related problems in the sliding window model---maintaining variance and maintaining a k--median clustering. Our solution to the problem of maintaining variance provides a continually updated estimate of the variance of the last N values in a data stream with relative error of at most e using O(1/e2 log N) memory. We present a constant-factor approximation algorithm which maintains an approximate k--median solution for the last N data points using O(k/τ4 N2τ log2N) memory, where τ