gebhart/patrepeval huggingface dataset:
Speech monitoring of infective laryngitis (2002)

Many types of parameters have been proposed for the evaluation of vocal cord abnormalities by speech waveform analysis. However, none of them taken separately allows a reliable assessment of the presence and the degree of abnormality. We propose combining three different parameters which take into account different consequences of the hoarseness. To assess the effectiveness of the parameters, a group of subjects during and after acute infective laryngitis are compared with control subjects. The jitter, the glottal to noise excitation (GNE) and the normalised error prediction (NEP) are the parameters studied. Preliminary results indicate that reliable discrimination between normal and abnormal patients may be possible using these three parameters.
Dual‐Color STED Microscopy at 30‐nm Focal‐Plane Resolution (2008)

Stimulated emission depletion (STED) fluorescence microscopy images protein distribution in cells in two-color channels at a resolution of ≈30 nm in the focal plane (see image), corresponding to a seven-to eightfold improvement over confocal microscopy resolution.
SDF-1α in Glycan Nanoparticles Exhibits Full Activity and Reduces Pulmonary Hypertension in Rats (2013)

To establish a homing signal in the lung to recruit circulating stem cells for tissue repair, we formulated a nanoparticle, SDF-1α NP, by complexing SDF-1α with dextran sulfate and chitosan. The data show that SDF-1α was barely released from the nanoparticles over an extended period of time in vitro (3% in 7 days at 37 °C); however, incorporated SDF-1α exhibited full chemotactic activity and receptor activation compared to its free form. The nanoparticles were not endocytosed after incubation with Jurkat cells. When aerosolized into the lungs of rats, SDF-1α NP displayed a greater retention time compared to free SDF-1α (64 vs 2% remaining at 16 h). In a rat model of monocrotaline-induced lung injury, SDF-1α NP, but not free form SDF-1α, was found to reduce pulmonary hypertension. These data suggest that the nanoparticle formulation protected SDF-1α from rapid clearance in the lung and sustained its biological function in vivo.
Study of messenger RNA inactivation and protein degradation in an Escherichia coli cell-free expression system (2010)

The global mRNA turnover and the protein degradation rate can be accelerated and tuned in a biologically relevant range in a cell-free reaction with quantitative procedures easy to implement. These features broaden the capabilities of cell-free systems with a better control of gene expression. This cell-free extract could find some applications in new research areas such as in vitro synthetic biology and systems biology where engineering informational processes requires a quantitative control of mRNA inactivation and protein degradation.
Organizational Justice and Organizational Citizenship Behavior in Higher Education Institution (2010)

A new expandable breast implant for use in hypomastia is presented. The ability to manipulate the size of the implant postoperatively greatly enhanced the final results.
Real-time face detection in color video (2004)

In this paper, we propose a novel and fast face detection algorithm for detecting face in color video sequences. This algorithm can be integrated into a real-time surveillance or a video retrieval in the design of the algorithm. A set of multiresolution Haar wavelet coefficients pairs is selected by the proposed learning algorithm to determine if a particular region is a face. We apply an ID3-like balanced decision tree for the wavelet coefficients quantization, to reduce the quantization error. For each pair of quantized features, we estimate the associated conditional joint probability density function from a large set of face and non-face training data. Then, we compute the Kullback Leibler (KL) distance to measure the discrimination between the face and non-face conditional density functions for each feature pair. The feature pairs with larger KL-distance are selected as the feature candidates. It is an effective feature dimension reduction method and helps to speedup the Adaboost training algorithm when considering the spatial relationship between all coefficient pairs. Aided by an automatic skin color judgment method and a Gaussian face location model both in temporal and spatial domain, the experiments show that the proposed algorithm runs faster than 4 times the video rate with good detection accuracy.
Theoretical Analysis of the Detailed Mechanism of Native Chemical Ligation Reactions (2011)

The method of native chemical ligation between an unprotected peptide α-thioester and an N-terminal cysteine-peptide to give a native peptide in aqueous solution is one of the most effective peptide ligation methods. In this work, a systematic theoretical study was carried out to fully understand the detailed mechanism of ligation. It was found that for the conventional native chemical ligation reaction between a peptide thioalkyl ester and a cysteine in combination with an added aryl thiol as catalyst, both the thiol-thioester exchange step and the transthioesterification step proceed by an anionic concerted S(N)2 displacement mechanism, whereas the intramolecular rearrangement proceeds by an addition-elimination mechanism, and the rate-limiting step is the thiol-thioester exchange step. The theoretical method was then extended to study the detailed mechanism of the auxiliary-mediated peptide ligation between a peptide thiophenyl ester and an N-2-mercaptobenzyl peptide in which both the thiol-thioester exchange step and intramolecular acyl-transfer step proceed by a concerted S(N)2-type displacement mechanism. The energy barrier of the thiol-thioester exchange step depends on the side-chain steric hindrance of the C-terminal amino acid, whereas that of the acyl-transfer step depends on the side-chain steric hindrance of the N-terminal amino acid.
Agonistic CD40 antibody induces immune-mediated liver damage and modulates tumor-induced myeloid suppressive cells (2014)

Meeting abstracts Immune stimulatory monoclonal antibodies are currently evaluated as anti/cancer agents in clinical trials. While overall toxicity seems to be moderate, liver toxicities have been reported and are not completely understood. Based on the observation that CD11b+Gr-1+ MDSC accumulate
[Use of taurolin in the prevention of septic complications in emergency abdominal surgery]. (1991)

The purpose of the study was to evaluate effectiveness of local application of Taurolin in prevention of septic complications after abdominal emergency surgery. Group A included 30 patients in whom intraoperative peritoneal lavage was performed with 0.5% solution of taurolin. In the first 12 postoperative hours peritoneal lavage was repeated through the drain. Group B included 30 patients in whom intraoperative lavage was performed with either physiologic saline or Povidon solution. All patients had suppurative peritonitis provoked by perforation of some of the abdominal organs. Intraoperatively samples of abdominal pus were taken for bacteriological analysis, while postoperatively samples were taken from drains placed abdominally and subcutaneously. Twelve hours after the surgery therapy was conducted according to the operative findings, postoperative course, x-ray and laboratory findings and results of sensitivity testing. Analysis of the results revealed significant differences in postoperative morbidity and mortality between the two groups. No fatal outcomes were recorded in the immediate postoperative course in group A where only one case of recurrent intraperitoneal infection occurred and three cases of wound infection. In group B, however, three patients died in the immediate postoperative course, recurrent intraperitoneal infection developed in four cases and wound infection in 12. Intraoperative and early postoperative local application of Taurolin in addition to appropriate surgical treatment and postoperative care has an important role in prevention of postoperative septic complications and decrease of postoperative mortality.
Convection-based micromachined inclinometer using SOI technology (2002)

This paper presents a novel inclinometer operating with the free-convection heat transfer principle which has been developed at the HSG-IMIT for the VOGT electronic company. The use of SOI-technology permits a short technological process for the sensor fabrication and a very good mechanical stability like a high reproducibility. Using free convection properties the sensor presents a high resolution (0.007/spl deg/), a great sensitivity and baseline stability.
Thrombomodulin Modulates the Mitogenic Response to Thrombin of Human Umbilical Vein Endothelial Cells (1998)

Summary Thrombin interacts with its receptor and thrombomodulin on endothelial cells. We evaluated the respective roles of these two proteins on human umbilical vein endothelial cell (HUVEC) growth by comparing thrombin, S195A (a mutant thrombin in which the serine of the charge stabilizing system had been replaced by alanine), and the receptor activating peptide (TRAP). Thrombin and TRAP induced DNA synthesis (half maximal cell proliferation with 5 nM and 25 μM, respectively), whereas S195A thrombin was inactive, inferring that growth is mediated through the thrombin receptor. Surprisingly, cells stimulated by TRAP exhibited a maximal proliferation twice greater than that obtained with thrombin. Combination of thrombin and TRAP resulted in a mitogenic response higher than by thrombin alone, but lower than by TRAP alone. The role of thrombomodulin was evaluated by adding an anti-thrombomodulin antibody, which prevents formation of the thrombin-thrombomodulin complex. Antibody did not interfere with cell proliferation induced by TRAP, but enhanced that induced by thrombin. We conclude that formation of the thrombin-thrombomodulin complex restrains HUVEC proliferation mediated through the thrombin receptor.
Inhibitory Effect of Seabuckthorn (Hippophea rhamnoides) on Platelet Aggregation and Oxidative Stress (2010)

Extracts from seabuckthorn (Hippophea rhamnoides) leaves, fruit and seed oil were screened for anti-platelet properties in-vitro using human platelets stimulated with 0.2 mM ADP. Half maximal inhibitory concentration was found to be 55 microg/ml platelet rich plasma(PRP) for leaf extract, 47.7 microg/ml PRP for fruit extract and 0.62 microl/ml PRP for seed oil. In-vitro incubation of platelets with increasing concentrations of seed oil was found to inhibit oxidative stress in resting as well as agonist stimulated platelets as evident by decreased formation of peroxide and superoxide radicals. Leaf extract and seed oil were further evaluated for antiplatelet and antioxidant action in-vivo in cholesterol-induced experimental atherosclerosis in rabbits. Rabbits fed on diet supplemented with cholesterol (0.5% or 1%) for 60 days showed statistically significant increase in platelet aggregation stimulated by ADP and collagen as compared to platelet aggregation in control rabbits. Malondialdehyde levels in platelets of cholesterol fed rabbits were significantly higher than those of control rabbits. Both leaf extract and seed oil supplementation prevented cholesterol induced alterations in platelet aggregation and platelet malondialdehyde levels. The study shows that SBT leaf extract and seed oil inhibit oxidative stress and hyperactivity of platelets both in-vitro as well as in-vivo and plausibly attenuate atherogenesis.
Aggregation under a forced convective flow (1992)

Morphological transitions are analyzed for a radial multiparticle diffusion-limited aggregation process grown under a convective drift. The introduction of a tangential flow changes the morphology of the diffusion-limited structure, into multiarm structures, inclined opposite to the flow, whose limit consists of single arms, when decreasing density. The case of shear flow is also considered. The anisotropy of the patterns is characterized in terms of a tangential correlation function based analysis. Comparison between the simulation results and preliminary experimental results has been done.
Evaluation of Rhizosphere Bacteria for Biological Control of Pythium Root Rot of Greenhouse Cucumbers in Hydroponic Culture (1994)

Five bacterial isolates were evaluated for their ability to reduce root rot caused by Pythium aphanidermatum (Pa) on cucumber (Cucumis sativus L. cv. Corona) grown under simulated commercial conditions in a rock wool hydroponic system. Two isolates of Pseudomonas corrugata (Pc13 and Pc35) and three of Pseudomonas fluorescens (Pf15, Pf16, and Pf27) were evaluated in both spring and early fall 1991 crops. Isolates Pc13, Pc35, and Pf15 were also evaluated in a 1992 spring crop. In all crops, 5-wk-old plants were set onto rock wool slabs and treated with water or 200 ml of a bacterial suspension (10 6 cells per milliliter)
SBLWT: A Secure Blockchain Lightweight Wallet Based on Trustzone (2018)

Due to the increasing total value of the digital currency, the security of encryption wallet is becoming more and more important. The hardware-based wallet is safe, but it is inconvenient because users need to carry an additional physical device, the software-based wallet is convenient, but the safety cannot be guaranteed. All these wallets need to synchronize the blockchain, while most current mobile devices do not have the capability to store all blocks. To solve these problems, mobile devices can use simplified payment verification (SPV). Nevertheless, in existing methods, there is no good way to protect the verification process of the transaction. In this paper, we design a secure blockchain lightweight wallet based on Trustzone to protect SPV. It is more portable compared with the hardware wallet, and safer than the software wallet. Through the isolation, it can also protect the private key and the wallet's address from being stolen by the attackers no matter whether the Rich OS is malicious or not. Meanwhile, it can protect the verification process by verifying transactions in the secure execution environment (SEE), and keep the local block headers unreadable directly from the Rich OS through encryption. We deploy it on the RASPBERRY PI 3 MODEL B development board. The result of the experiment shows that it has little impact on the system.
Comparative study of polarized light propagation in biologic tissues (2002)

We report the depolarization of light scattered by a variety of birefringent and nonbirefringent tissues. We used Stokes polarimetry to investigate how scatterer structures in each tissue contribute to the depolarization of linearly versus circularly polarized light propagating through that tissue. Experiments were performed on porcine blood, fat, tendon, artery, and myocardium. The results indicate that the two incident polarization states are depolarized differently depending on the structure of the sample. As seen in sphere suspensions, for tissues containing dilute Mie scatterers, circularly polarized light is maintained preferentially over linearly polarized light. For more dense tissues, however, the reverse is true. The results illustrate situations where polarized light will provide an improvement over unpolarized light imaging, information that is crucial to optimizing existing polarimetric imaging techniques.
Pharmacokinetics of Once-Daily Ip Gentamicin in Capd Patients (1996)

Currently recommended doses of once-daily IP gentamicin for the treatment of peritonitis may not produce the desired therapeutic serum and dialysate concentrations over 24 hours for effective treatment of peritonitis.
Higher Alcohols from Synthesis Gas Using Carbon-Supported Doped Molybdenum-Based Catalysts (1998)

A series of carbon-supported molybdenum-based catalysts was prepared by incipient wetness impregnation. The materials, when promoted with potassium and additionally with cobalt, were screened for the selective production of mixed higher-molecular-weight alcohols from syngas. The effects of the catalyst preparation parameters (Mo precursor, Mo loading, doping levels of K and Co, and calcination) and of the reaction conditions (temperature and space velocity) were studied. The screening procedure consisted of ramping the temperature steadily from 200 to 400 °C and back again. Adding K results in a maximum in the space−time yield (STY) of total alcohols and the ratio of higher alcohols to methanol. Increasing the reaction temperature results in a monotonic increase in the STY of hydrocarbons, a monotonic decrease in the selectivity toward alcohols, and a maximum in the STY of alcohols. Increasing the space velocity increases the STY and selectivity to alcohols while decreasing the STY of hydrocarbons. Increasing the space velocity also decreases the higher-alcohol fraction in the alcohol products.
The Gene for the Ellis–van Creveld Syndrome Is Located on Chromosome 4p16 (1996)

Ellis–van Creveld syndrome (EVC) is an autosomal recessive disorder characterized by disproportionate dwarfism, polydactyly, and congenital heart disease. This rare disorder is found with increased frequency among the Old Order Amish community in Lancaster County, Pennsylvania. We have used linkage analysis to localize the gene responsible for the EVC phenotype in nine interrelated Amish pedigrees and three unrelated families from Mexico, Ecuador, and Brazil. We now report the linkage for the Ellis–van Creveld syndrome gene to markers on the distal short arm of human chromosome 4, withZmax= 6.91 at θ = 0.02 for marker HOX7, in a region proximal to theFGFR3gene responsible for the achondroplasia phenotype.
Prediction of the incidence of motion sickness from the magnitude, frequency, and duration of vertical oscillation (1987)

A method is proposed by which the incidence of motion sickness may be predicted from measurement of the motion exposure. The method is based on data from both field and laboratory studies involving large numbers of people and is applicable to marine and other environments where vertical oscillation occurs at frequencies below 0.5 Hz. The dependence of motion sickness on the frequency of oscillation requires the use of a weighting function between 0.1 and 0.5 Hz. The dependence of sickness on the duration of exposure is incorporated by the use of a cumulative measure of motion dose based on the product of root-mean-square (rms) acceleration magnitude and the square root of stimulus duration. The influence of population variables such as sex, age, and motion experience is discussed. The method enables separate predictions to be made of vomiting incidence and of feelings of illness. The prediction procedure, while not seeking to explain the underlying mechanisms of motion sickness occurrence, provides a generally applicable method which is simple to use and has an accuracy consistent with the experimental data on which it is based.
Prediction of Licensing Examination Scores in Physical Therapy Graduates (1988)

The primary purpose of this study was to determine which information available on applicants to the University of New Mexico physical therapy program would best predict performance on the licensing examination. The secondary purpose was to provide documentation of a procedure for selection that could be useful to other programs in other settings. American College Testing (ACT) scores, prerequisite and nonprerequisite grade point averages (GPAs), and interview and recommendation scores were used to predict licensing examination scores for the classes graduating from 1980 to 1984. Six of the regression analyses were significant, but three had similar correlations that were much higher than the rest. The variables in those three regression analyses were ACT composite score and both GPAs; ACT composite score, both GPAs, and interview score; and ACT composite score, prerequisite GPA, and interview score. The results of this study suggest that selection committees use standardized ability tests as admission criteria because the ACT scores accounted for the most variance in licensing examination scores. Other professional schools might also benefit by applying the procedures used in this study to their own data to develop prediction equations.
Modern nickel superalloys and the efficient resource-saving technologies of their production (2015)

A spectrum of nickel superalloys having a unique combination of properties is developed. They can operate at a gas temperature of 2000–2200 K, which makes it possible to increase the characteristics of engines and aircrafts substantially.
Distal Locking Screw Insertion Using a Cannulated Drill Bit: Technical Note (1993)

A modified freehand method using a cannulated drill bit for the insertion of distal locking screws for interlocking intramedullary nails is described. It should be useful to introduce surgeons to interlocking and to aid those who are not comfortable with the freehand method.
Binarization-free OCR for historical documents using LSTM networks (2015)

A primary preprocessing block of almost any typical OCR system is binarization, through which it is intended to remove unwanted part of the input image, and only keep a binarized and cleaned-up version for further processing. The binarization step does not, however, always perform perfectly, and it can happen that binarization artifacts result in important information loss, by for instance breaking or deforming character shapes. In historical documents, due to a more dominant presence of noise and other sources of degradations, the performance of binarization methods usually deteriorates; as a result the performance of the recognition pipeline is hindered by such preprocessing phases. In this paper, we propose to skip the binarization step by directly training a 1D Long Short Term Memory (LSTM) network on gray-level text lines. We collect a large set of historical Fraktur documents, from publicly available online sources, and form train and test sets for performing experiments on both gray-level and binarized text lines. In order to observe the impact of resolution, the experiments are carried out on two identical sets of low and high resolutions. Overall, using gray-level text lines, the 1D LSTM network can reach 24% and 19% lower error rates on the low- and high-resolution sets, respectively, compared to the case of using binarization in the recognition pipeline.
ESA/390 Integrated Cryptographic Facility: An overview (1991)

This paper reviews the objectives of the Enterprise Systems Architecture/390™ (ESA/390™) Integrated Cryptographic Facility. It presents the cryptographic key-management scheme, summarizes key elements and unique characteristics of the facility, and describes the physical security provided by the first ESA/390 implementation.
Metabolic disposition of enciprazine, a non-benzodiazepine anxiolytic drug, in rat, dog and man (1991)

1. The excretion and metabolism of enciprazine, an anxiolytic drug, was examined in rat, dog and man. 2. In rats and dogs that received 14C-enciprazine dihydrochloride orally and by i.v. injection, the drug was well absorbed. Radioactivity was excreted predominantly in the faeces of rats, equally in urine and faeces of dogs, and to a major extent in human urine. 3. Metabolic profiles, which were evaluated in urine and in rat bile, were similar following oral and i.v. dosing to rats and dogs. 4. Unchanged drug was not detected in rat, dog or human excreta. Glucuronide conjugates of 4-hydroxyenciprazine, m-desmethylenciprazine, p-desmethylenciprazine and enciprazine were detected in the excreta of all three species. A glycol metabolite was present only in rat bile and human urine. A metabolite desmethylated in the phenyl ring of the phenylpiperazine moiety also appeared to be present only in human urine. 5. Structural confirmation of the major metabolites in human urine and rat bile was accomplished by h.p.l.c.-mass spectrometry.