gebhart/patrepeval huggingface dataset:
Ко Всемирному дню почки 2020 Болезни почек - будем настороже! (2020)

No abstract
Large-scale discriminative language model reranking for voice-search (2012)

We present a distributed framework for largescale discriminative language models that can be integrated within a large vocabulary continuous speech recognition (LVCSR) system using lattice rescoring. We intentionally use a weakened acoustic model in a baseline LVCSR system to generate candidate hypotheses for voice-search data; this allows us to utilize large amounts of unsupervised data to train our models. We propose an efficient and scalable MapReduce framework that uses a perceptron-style distributed training strategy to handle these large amounts of data. We report small but significant improvements in recognition accuracies on a standard voice-search data set using our discriminative reranking model. We also provide an analysis of the various parameters of our models including model size, types of features, size of partitions in the MapReduce framework with the help of supporting experiments. 1
Efficacy of Plant-Derived and Synthetic Compounds on Clothing as Repellents Against<i>Ixodes scapularis</i>and<i>Amblyomma americanum</i>(Acari: Ixodidae) (2012)

We conducted field trials to compare the relative repellent activity of two natural product compounds (nootkatone and carvacrol) with commercially available plant-derived (EcoSMART organic insect repellent) and permethrin-based (Repel Permanone) repellents against adult Ixodes scapularis Say and Amblyomma americanum (L.) (Acari: Ixodidae) by using treated coveralls. One day after treatment, nootkatone and carvacrol provided 100% repellency of I. scapularis adults, with nootkatone maintaining complete protection through 3 d, whereas carvacrol showed steadily declining repellency against I. scapularis during the 7-d course of the trials. Nootkatone was at least as effective against host-seeking A. americanum as against I. scapularis through 3 d. Carvacrol provided little protection against A. americanum adults. Both natural compounds performed well initially in comparison with the commercial products. After 7 d, nootkatone was the most effective against both species followed in order of activity by Permanone, EcoSMART, and carvacrol. Nootkatone seems to have offer considerable potential as a clothing repellent against both I. scapularis and A. americanum.
Taxol induces microtubule assembly at low temperature (1981)

Dissociated bovine brain microtubule protein has been shown to reassemble at 0 degrees C in the presence of the drug taxol. Tubulin polymerization was monitored both by electron microscopy of the polymeric structures and by incorporation of tritiated GTP into filterable polymeric structures. Most of the labeled guanine nucleotide uptake into tubulin polymeric structures occurred in the first 30 minutes of incubation with the drug. The initial polymerization event results in the formation of protofilamentous tubulin ribbons. The first microtubules were noted after 1 hour of incubation with the drug. After 20 hours of incubation at 0 degrees C with taxol, the bulk of the polymerized tubulin appeared to be in the form of microtubules. Cold-stable tubulin rings with a mean diameter of 34 nm were present in the reaction mixture before the addition of taxol and throughout the 20-hour incubation. Most of the rings were apparently not involved in the taxol-induced microtubule assembly. The results are consistent with a model whereby taxol induces an initial formation of protofilamentous ribbon structures, mostly from free tubulin dimers, and a slower subsequent folding of the ribbon structures into microtubules.
Biophysical targeting of adenovirus vectors for gene therapy. (2000)

Advances in understanding the interaction of animal viruses with their cognate receptors has led to improvements in the development of cell-specific, targeted viral vectors. Research strategies to generate safe, non-inflammatory viral vectors that are capable of delivering a therapeutic gene to a specific population of cells are currently underway in many laboratories. One approach in the utilization of this cell targeting activity is to ablate the natural interaction of the virus with its native receptor, although this is not an absolute requirement. The initial development of 'viral targeting strategies' was based on the view that by modifying the viral protein/receptor interaction, it would be possible to redirect virus vectors to new host cells. As the understanding of virus/cell interactions increased it was observed, however, that many viruses can use different entry mechanisms for cell attachment and penetration. Adenovirus vectors have been used extensively for the delivery of genes to cells. The entry mechanism for adenoviruses into cells has recently been studied and is relatively well understood, however, there are many aspects of cell receptor/virus interactions, which have still to be elucidated. The single high-affinity receptor on mammalian cells for adenovirus type 5 is recognized as the coxsackie and adenovirus receptor. However, in the absence of coxsackie and adenovirus receptor other receptors are used. A thorough understanding of the biology of adenoviruses is essential in the further development of their use as vectors for cell targeting. One strategy is to modify the viral capsid, either through coating the surface using bispecific antibodies, or by chemically crosslinking the targeting ligand onto the virion surface. Another approach is to genetically modify the virus by incorporating the targeting ligand into the viral 'spike' (fiber) protein. This involves manipulating the adenovirus genome and generating a new targeting ligand on the surface of the fiber protein using recombinant DNA technology. The penton base protein has also received attention as a means of directing adenoviruses via insertion of novel targeting ligands.
SC-54684A: An Orally Active Inhibitor of Platelet Aggregation (1995)

SC-54684A, an orally active antiplatelet drug now in clinical trial, is shown to be a potent, specific fibrinogen binding inhibitor that blocks platelet aggregation to a wide variety of known stimuli and has good bioavailability in animals.
Functional expression of the taste specific G-protein, <i>α</i>-gustducin (1995)

The taste-specific G-protein alpha-subunit, alpha-gustducin, was expressed using a baculovirus based system. alpha-Gustducin was demonstrated to be myristoylated and was also palmitoylated in insect larval cells. Recombinant alpha-gustducin was purified to homogeneity. Neither receptors nor effectors that interact with gustducin in taste are known. However, alpha-gustducin has a close structural similarity to the visual G-protein, alpha-transducin. Therefore alpha-gustducin was reconstituted with components of the visual system to determine the degree of its functional similarity with alpha-transducin. Despite the fact that the sequences of alpha-gustducin and alpha-transducin share only 80% identity with each other, the interactions and functions of these two proteins were quantitatively identical. These included the interaction with receptor, bovine rhodopsin, with effector, bovine retinal cyclic GMP-phosphodiesterase, and with bovine brain and retinal G-protein beta gamma-heterodimers; receptor-catalysed GDP-GTP exchange and the intrinsic GTPase activity of alpha-gustducin and alpha-transducin were also identical. Gi alpha which is 70% identical with alpha-transducin interacts with different receptor and effector proteins and has very different guanine-nucleotide binding properties. Therefore, the functional equivalence of alpha-gustducin and alpha-transducin suggest that taste buds are likely to contain receptor and effector proteins that share many properties with their retinal equivalents.
The effects of pharmaceutical excipients on small intestinal transit. (1995)

1. The effect of three iso-osmotic pharmaceutical excipient solutions on gastrointestinal transit were investigated in eight healthy male volunteers. Each subject received 200 ml radiolabelled purified water, or a 200 ml solution of sodium acid pyrophosphate ((SAPP) 1.1 g/200 ml), mannitol (2.264 g/200 ml) or sucrose (4.08 g/200 ml) in a four way cross over design. On each of the study days the volunteers also received five 6 mm diameter non-disintegrating tablets. Dual isotope gamma scintigraphy was used to assess the transit behaviour of the tablets and solutions. 2. There were no significant differences between the gastric emptying times of the four solution formulations. Rapid gastric emptying was observed in all cases (mean t 50% varied from 11-14 min). 3. Small intestinal transit (SIT) times for the SAPP and mannitol solutions were reduced by 39 and 34%, respectively, when compared with the control solution (purified water = 240 min; SAPP = 147 min; mannitol = 158 min). The 95% confidence limits for the mean differences in SIT time between the control and SAPP solutions was 39-94-149 min, and 40-82-124 min between the mannitol and the control. Intestinal transit for the sucrose solution was similar to that for the control solution (sucrose = 229 min). 4. There were no significant differences in the transit times of the non-disintegrating tablet preparations, when co-administered with each solution.(ABSTRACT TRUNCATED AT 250 WORDS)
Content-based access to spoken audio (2005)

This article describes approaches to content-based access to spoken audio with a qualitative and tutorial emphasis. We describe how the analysis, retrieval, and delivery phases contribute to making spoken audio content more accessible and outline outstanding research issues. We also discuss the main application domains and identify important issues for future developments. The structure of the article is based on the general system architecture for content-based access. Although the tasks within each processing stage may appear unconnected, the interdependencies and the sequence with which they take place vary.
OSTEOPOROSIS AFTER RENAL TRANSPLANTATION: SINGLE CENTER EXPERIENCE (2001)

Time since transplantation and cumulative prednisolone doses were significantly higher in patients who had osteoporosis of the lumbar vertebrae (P=0.06 and 0.034, respectively). Logistic regression analysis revealed that cumulative prednisolone dose was the only significant predictor of low vertebral BMD (P=0.02, r=0.33). For the neck of the femur, high blood urea nitrogen and low Mg levels were found to be the predictors of low bone density (P=0.002 and 0.04, respectively). Although parathyroid hormone levels were higher in femoral osteoporosis patients than in those not affected at this site, the difference was not statistically significant (P=0.294). Time since transplantation, cumulative prednisolone dose, and cyclosporine A dose were all found to have a major negative impact on BMD in the radius region (P=0.001, 0.000, 0.001, respectively). Regression analysis showed that cumulative prednisolone dose (P=0.0008, r=0.34), time since transplantation (P=0.005, r=0.27), body mass index (P=0.01, r=-0.21), male gender (P=0.02, r=-0.21), and age (P=0.04, r=0.16) all had major effects on radius BMD. In conclusion, the radius seems to be one of the major parts of the skeleton affected by factors introduced after renal transplantation.
Surface Degradation of Silicone Rubber Exposed to Corona Discharge (2006)

This paper describes the surface degradation of unfilled high-temperature vulcanized silicone rubber (HTV-SR) resulting from creeping corona discharges under atmospheric pressure. In this paper, HTV-SR specimens were exposed to corona stress generated by a parallel needle-plate electrode system; furthermore, physicochemical analyses were conducted on the surface layer of SR before and after corona discharge treatment. The results showed that the plasma impingement from the corona discharge can cause physical and chemical damages to the SR surface. In addition, it was demonstrated that instead of hydrophobic CH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> groups, hydrophilic OH groups that are by-products of aging may be formed on the surface of aged SR; furthermore, the corona discharge plays an important role in the loss of hydrophobicity
A concept for a virtual flight deck shown on an HMD (2016)

A combination of see-through head-worn or helmet-mounted displays (HMDs) and imaging sensors is frequently used to overcome the limitations of the human visual system in degraded visual environments (DVE). A visual-conformal symbology displayed on the HMD allows the pilots to see objects such as the landing site or obstacles being invisible otherwise. These HMDs are worn by pilots sitting in a conventional cockpit, which provides a direct view of the external scene through the cockpit windows and a user interface with head-down displays and buttons. In a previous publication, we presented the advantages of replacing the conventional head-down display hardware by virtual instruments. These virtual aircraft-ﬁxed cockpit instruments were displayed on the Elbit JEDEYE system, a binocular, see-through HMD. The idea of our current work is to not only virtualize the display hardware of the ﬂight deck, but also to replace the direct view of the out-the-window scene by a virtual view of the surroundings. This imagery is derived from various sensors and rendered on an HMD, however without see-through capability. This approach promises many advantages over conventional cockpit designs. Besides potential weight savings, this future ﬂight deck can provide a less restricted outside view as the pilots are able to virtually see through the airframe. The paper presents a concept for the realization of such a virtual ﬂight deck and states the expected beneﬁts as well as the challenges to be met.
Identification of multifunctional small molecule-based reversible monoamine oxidase inhibitors (2011)

The design of multifunctional, neuroprotective compounds has received increasing attention due to their perceived utility in targeting not only the diverse comorbidity of neurological disorders, but also the typically complex pathoetiological pathways leading to these disorders, including insoluble proteins associated with many human neurodegenerative diseases of aging and radical-generating enzyme actions in the brain. For this purpose, herein, we present inhibitory studies on monoamine oxidase (MAO) of a chemical library composed of stilbene-like derivatives that have potential applications in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), with the ability to modulate metal-induced amyloid-β (Aβ) aggregation and neurotoxicity in vitro and in living cells. Two isoforms of MAO, MAOA and MAOB, are well-known drug targets for depression and Parkinson's disease (PD), respectively. Interestingly, inhibition and binding affinity studies of MAO with our chemical series indicated that three compounds, L1-b, L2-b, and L3-b, exhibited potent and relatively selective inhibitory effects of MAOB. In particular, L2-b was observed to be the most effective MAOB inhibitor in our chemical library showing a reversible and competitive inhibition. Generally, compounds having a dimethylamino moiety in our chemical family showed greater MAO inhibition suggesting a structure–activity relationship. Overall, our findings demonstrate that the stilbene-like scaffolds could be utilized for developing promising multifunctional, neuroprotective agents for several neurodegenerative diseases.
Synthesis and Antimicrobial Activity of Some Novel 4-(1H-Benz[d]imidazol-2yl)-1,3-thiazol-2-amines (2010)

A new series of novel 4-(1H-benz[d]imidazol-2yl)-1,3-thiazol-2-amines 5a-d and 4-(1H-benz[d]imidazol-2yl)-3-alkyl-2,3-dihydro-1,3-thiazol-2-amine 8a-d has been synthesized by the cyclocondensation of 2-acetyl benzimidiazoles 4a-d and 2-bromo-1-(1-alkyl-1H-benzo[d]imidazol-2-yl)-1-ethanone 7a-d with thiourea respectively, and evaluated for their antibacterial and antifungal activity against clinical isolates of Gram-positive and Gram-negative bacteria. Some of these hybrids in these series exhibited antibacterial activity comparable to standard Streptomycin and Benzyl penicillin and antifungal activity against Fluconazole. All the newly synthesized compounds were characterized by their spectral data and further used to estimate their ability towards antimicrobial activity.
Risk factors in the development of pressure ulcers in an intensive care unit in Pontianak, Indonesia (2007)

The purpose of this study was to identify risk factors associated with the presence of pressure ulcer development in adult patients at an intensive care unit hospital in Indonesia. The prospective cohort design was conducted in this study. A total of 105 patients participated and a pressure ulcer developed in 35 patients. The initial analysis identified several variables as significant risk factors for pressure ulcer development (interface pressure, fecal incontinence, skin moisture, diastolic blood pressure, smoking and body temperature). However, when entered into a final multivariate analysis, four factors, interface pressure [odds ratio (OR) 17.6, 95% confidence interval (CI) 4.1, 74.3], skin moisture (OR 8.2, 95% CI 2.2, 30.9), smoking (12.7, 95% CI 2.8, 56.7) and body temperature (OR 102.0, 95% CI 7.7, 98.8) were found to be significant. The results suggest that interface pressure measured using a multipad pressure evaluator, skin moisture measured by a moisture checker, thermometer for body temperature and smoking status are adequate instruments for the prediction of pressure ulcer development.
Fast-Clearing Spray Chamber for ICP-AES (1994)

The rapid-clearing spray chamber design utilizes two critical features for a rapid-clearing system—a nebulizer wash and a high-volume gas flush. The combination of these two features with supporting design features provides a system which can clear out a signal of Fe or Zn from 500 ppm to undetectable levels (below 10 ppb) in about 20 s. A tubular injector is used in the ICP torch to minimize plasma disturbance during the gas flush cycle. Several modifications to the spray chamber were necessary to handle the nebulizer wash efficiently.
Study on Surface Modification of Indium Tin Oxide and Resist Surfaces Using CF<sub>4</sub>/O<sub>2</sub> Plasma for Manufacturing Organic Light-Emitting Diodes by Inkjet Printing (2008)

We studied a surface modification technique for indium tin oxide (ITO) anodes without precleaning and resist banks for manufacturing organic light-emitting diodes (OLEDs) by inkjet printing. The ITO surface modified by inductively coupled plasma (ICP) with an optimized CF4/O2 (7:3) gas mixture improved both its hydrophilicity and its work function, while the resist surface treated by the plasma became hydrophobic. The resist and ITO surfaces treated by plasmas of various gas mixtures (i.e., CF4, CF4/Ar (1:2), CF4/O2 (x:1; x=1, 7/3, 4, and 9) were analyzed by X-ray photoelectron spectroscopy (XPS) of the C 1s, F 1s, O 1s, and In 3d5/2 core levels. On the uncleaned ITO surfaces modified by CF4/O2 plasmas, organic contaminants were removed more efficiently and the deposition of CFx on the remaining contaminants decreased with increasing oxygen. The amount of F in the form of InFx increased using the CF4/O2 (7:3) plasma in comparison with that using the CF4/Ar and CF4 plasmas. We investigated the effect of adding oxygen to CF4 on the change in gaseous species produced in the plasma chamber by mass spectrometry. In the CF4/O2 (7:3) plasma, the peak intensities of F+, HF+, F2+, O+, and O2+ were higher than those in the CF4 plasma. The results suggest that In2O3 was generated by the oxidation of indium with O, and InFx was generated by the fluoridation of indium with HF. By introducing InFx onto ITO surfaces using the CF4/O2 plasma, the hole-injection energy barrier could be reduced.
Evolutionary relationships among the serpins (1993)

The serpins are a widely distributed group of serine proteinase inhibitors found in plants, birds, mammals and viruses. Despite the great evolutionary divergence of these organisms, their serpins are highly conserved, both in sequence and structurally. Amino acid sequences were aligned by a combination of automatic algorithms and by consideration of conserved structural elements in those serpins for which crystal structures exist. The program HOMED was used which allowed the alignment of amino acids to be simultaneously converted into the equivalently aligned nucleotide sequences. The aligned amino acids were used as the basis for superposition of the four known three-dimensional structures for which coordinates are available and compared with an optimal three-dimensional superposition in order to estimate the reliability of the sequence alignment. Phylogenetic relationships implied by these nucleotide sequence alignments were determined by the method of maximum parsimony. The proposed gene tree suggested that as much diversity existed between the plant serpin and mammalian serpins as was present among mammalian serpins and provided further evidence that the architecture of serpin molecules is highly constrained.
A simple and robust electron beam source from carbon nanotubes (1996)

A simple fabrication method is described to produce reliable and robust (self-repairing) field emission sources from randomly aligned carbon nanotubes. The sources display stable and reproducible current–voltage characteristics with sharp turn on near 100 V and emission currents up to 400 mA/cm2 at 200 V. Two successful methods are described for patterning the emission source area into emitting and nonemitting regions.
ReSHAPE: A Framework for Dynamic Resizing and Scheduling of Homogeneous Applications in a Parallel Environment (2007)

A traditional application scheduler running on a parallel cluster only supports static scheduling where the number of processors allocated to an application remains fixed throughout the lifetime of the job. Due to unpredictability in job arrival times and varying resource requirements, static scheduling can result in idle system resources thereby decreasing the overall system throughput. In this paper we present a prototype framework called ReSHAPE, which supports dynamic resizing of parallel MPI applications executed on distributed memory platforms. The framework includes a scheduler that supports resizing of applications, an API to enable applications to interact with the scheduler, and a library that makes resizing viable. Applications executed using the ReSHAPE scheduler framework can expand to take advantage of additional free processors or can shrink to accommodate a high priority application, without getting suspended. Experimental results show that the ReSHAPE framework can improve individual job turn-around time and overall system throughput.
Unified Model for Gas-Liquid Pipe Flow via Slug Dynamics—Part 1: Model Development (2003)

A unified hydrodynamic model is developed for predictions of flow pattern transitions, pressure gradient, liquid holdup and slug characteristics in gas-liquid pipe flow at all inclination angles from −90° to 90° from horizontal. The model is based on the dynamics of slug flow, which shares transition boundaries with all the other flow patterns. By use of the entire film zone as the control volume, the momentum exchange between the slug body and the film zone is introduced into the momentum equations for slug flow. The equations of slug flow are used not only to calculate the slug characteristics, but also to predict transitions from slug flow to other flow patterns. Significant effort has been made to eliminate discontinuities among the closure relationships through careful selection and generalization. The flow pattern classification is also simplified according to the hydrodynamic characteristics of two-phase flow.