gebhart/patrepeval huggingface dataset:
Penerapan Algoritma Minimax Pada Game Macan-macanan (2016)

Lots of traditional games, but now the game is becoming obsolete. Many games were replaced with the modern game technology products. Modern games are becoming more practical because it did not require the terrain and many friends. Quite alone in front of the screen was a person may engage in an exciting game. One of the efforts to preserve and disseminate traditional games one of which is macan-macanan is to adapt the game into a computer game. This study aims to apply artificial intelligence using minimax algorithms and programming language ActionScript 3 in the game with a macan-macanan research methods are prototyping. The design used in this study is an artificial intelligence approach for representing the state, science, human computer interaction for designing the user experience, as well as the UML for object-based design. Results from this study is that in order to determine the value of the evaluation algorithm minimax for the end node / terminal state in the game macan-macanan, required the calculation of the total step is valid for each piece, as well as to pawn macan, necessary calculations springboard to a higher value and the weight difference the appropriate type of pawns.
A public sector viewpoint of research (1988)

Conference Article| April 01 1988 A public sector viewpoint of research KEITH C. SHORT KEITH C. SHORT 1School of Science, Trent Polytechnic, Nottingham NG11 8NS, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1988) 16 (2): 128–129. https://doi.org/10.1042/bst0160128b Article history Received: November 16 1987 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation KEITH C. SHORT; A public sector viewpoint of research. Biochem Soc Trans 1 April 1988; 16 (2): 128–129. doi: https://doi.org/10.1042/bst0160128b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: CNAA, Council for National Academic Awards, AFE, advanced further education, LEA, local education authority, RCD, research degree committee This content is only available as a PDF. © 1988 Biochemical Society1988 Article PDF first page preview Close Modal You do not currently have access to this content.
Therapeutic targeting of α4-integrins in chronic inflammatory diseases: tipping the scales of risk towards benefit? (2005)

Inhibition of leukocyte trafficking via alpha4-integrin antibody blockade has recently become a validated therapeutic approach for several inflammatory diseases, including multiple sclerosis, ulcerative colitis and Crohn's disease. In the midst of this recent success, 3 patients receiving chronic treatment with the anti-alpha4 antagonist natalizumab (Tysabri) for the treatment of multiple sclerosis or Crohn's disease, developed JC-virus related progressive multifocal leukoencephalopathy (PML). These unforeseen consequences suggest that long term blockade of alpha4-integrins might prevent trafficking of non-pathogenic lymphocytes that are essential for viral immunosurveillance. In the current issue of the European Journal of Immunology Bjursten and colleagues report that long term treatment with anti-alpha4-integrin antibodies results in exacerbation of the murine model of colitis induced by the targeted deletion of the heterotrimeric G protein subunit Galphai2. In order to properly evaluate the efficacy and safety of anti-alpha4-integrin therapy, the relationship between these observations in an immunologically altered animal model and human clinical disease needs to be carefully measured.
Translational control by lysine-encoding A-rich sequences (2015)

Regulation of gene expression involves a wide array of cellular mechanisms that control the abundance of the RNA or protein products of that gene. Here we describe a gene-regulatory mechanism that is based on poly(A) tracks that stall the translation apparatus. We show that creating longer or shorter runs of adenosine nucleotides, without changes in the amino acid sequence, alters the protein output and the stability of mRNA. Sometimes these changes result in the production of an alternative "frame-shifted" protein product. These observations are corroborated using reporter constructs and in the context of recombinant gene sequences. Approximately two percent of genes in the human genome may be subject to this uncharacterized, yet fundamental form of gene regulation. The potential pool of regulated genes encodes many proteins involved in nucleic acid binding. We hypothesize that the genes we identify are part of a large network whose expression is fine-tuned by poly(A)-tracks, and we provide a mechanism through which synonymous mutations may influence gene expression in pathological states.
Similarity Learning with Spatial Constraints for Person Re-identification (2016)

Pose variation remains one of the major factors that adversely affect the accuracy of person re-identification. Such variation is not arbitrary as body parts (e.g. head, torso, legs) have relative stable spatial distribution. Breaking down the variability of global appearance regarding the spatial distribution potentially benefits the person matching. We therefore learn a novel similarity function, which consists of multiple sub-similarity measurements with each taking in charge of a subregion. In particular, we take advantage of the recently proposed polynomial feature map to describe the matching within each subregion, and inject all the feature maps into a unified framework. The framework not only outputs similarity measurements for different regions, but also makes a better consistency among them. Our framework can collaborate local similarities as well as global similarity to exploit their complementary strength. It is flexible to incorporate multiple visual cues to further elevate the performance. In experiments, we analyze the effectiveness of the major components. The results on four datasets show significant and consistent improvements over the state-of-the-art methods.
Comparative Proteomic Analysis of Tolerance and Adaptation of Ethanologenic<i>Saccharomyces cerevisiae</i>to Furfural, a Lignocellulosic Inhibitory Compound (2009)

The molecular mechanism involved in tolerance and adaptation of ethanologenic Saccharomyces cerevisiae to inhibitors (such as furfural, acetic acid, and phenol) represented in lignocellulosic hydrolysate is still unclear. Here, (18)O-labeling-aided shotgun comparative proteome analysis was applied to study the global protein expression profiles of S. cerevisiae under conditions of treatment of furfural compared with furfural-free fermentation profiles. Proteins involved in glucose fermentation and/or the tricarboxylic acid cycle were upregulated in cells treated with furfural compared with the control cells, while proteins involved in glycerol biosynthesis were downregulated. Differential levels of expression of alcohol dehydrogenases were observed. On the other hand, the levels of NADH, NAD(+), and NADH/NAD(+) were reduced whereas the levels of ATP and ADP were increased. These observations indicate that central carbon metabolism, levels of alcohol dehydrogenases, and the redox balance may be related to tolerance of ethanologenic yeast for and adaptation to furfural. Furthermore, proteins involved in stress response, including the unfolded protein response, oxidative stress, osmotic and salt stress, DNA damage and nutrient starvation, were differentially expressed, a finding that was validated by quantitative real-time reverse transcription-PCR to further confirm that the general stress responses are essential for cellular defense against furfural. These insights into the response of yeast to the presence of furfural will benefit the design and development of inhibitor-tolerant ethanologenic yeast by metabolic engineering or synthetic biology.
Extraction and classification of dense communities in the web (2007)

The World Wide Web (WWW) is rapidly becoming important for society as a medium for sharing data, information and services, and there is a growing interest in tools for understanding collective behaviors and emerging phenomena in the WWW. In this paper we focus on the problem of searching and classifying communities in the web. Loosely speaking a community is a group of pages related to a common interest. More formally communities have been associated in the computer science literature with the existence of a locally dense sub-graph of the web-graph (where web pages are nodes and hyper-links are arcs of the web-graph). The core of our contribution is a new scalable algorithm for finding relatively dense subgraphs in massive graphs. We apply our algorithm on web-graphs built on three publicly available large crawls of the web (with raw sizes up to 120M nodes and 1G arcs). The effectiveness of our algorithm in finding dense subgraphs is demonstrated experimentally by embedding artificial communities in the web-graph and counting how many of these are blindly found. Effectiveness increases with the size and density of the communities: it is close to 100% for communities of a thirty nodes or more (even at low density). It is still about 80% even for communities of twenty nodes with density over 50% of the arcs present. At the lower extremes the algorithm catches 35% of dense communities made of ten nodes. We complete our Community Watch system by clustering the communities found in the web-graph into homogeneous groups by topic and labelling each group by representative keywords.
<i>Trypanosoma cruzi</i> Infection Induces Proliferation of Vascular Smooth Muscle Cells (2005)

Trypanosoma cruzi infection causes cardiomyopathy and vasculopathy. Previous studies have demonstrated that infection of human umbilical vein endothelial and smooth muscle cells resulted in activation of extracellular signal-regulated kinase (ERK). In the present study, smooth muscle cells were infected with trypomastigotes, and immunoblot analysis revealed an increase in the expression of cyclin D1 and proliferating cell nuclear antigen (PCNA), important mediators of smooth muscle cell proliferation. Interestingly, after infection, the expression of caveolin-1 was reduced in both human umbilical vein endothelial cells and smooth muscle cells. Immunoblot and immunohistochemical analyses of lysates of carotid arteries obtained from infected mice revealed increased expression of PCNA, cyclin D1, its substrate, phospho-Rb (Ser780), and phospho-ERK1/2. The expression of the cyclin-dependent kinase inhibitor p21(Cip1/Waf1), caveolin-1, and caveolin-3 was reduced in carotid arteries obtained from infected mice. There was an increase in the abundance of pre-pro-endothelin-1 mRNA in the carotid artery and aorta from infected mice. The ET(A) receptor was also elevated in infected arteries. ERK activates endothelin-1, which in turn exerts positive feedback activating ERK, and cyclin D1 is a downstream target of both endothelin-1 and ERK. There was significant incorporation of bromodeoxyuridine into smooth muscle cell DNA when treatment was with conditioned medium obtained from infected endothelial cells. Taken together, these data suggest that T. cruzi infection stimulates smooth muscle cell proliferation and is likely a result of the upregulation of the ERK-cyclin D1-endothelin-1 pathway.
A Survey of Heterojunction Bipolar Transistor (HBT) Device Reliability (2004)

Heterojunction bipolar transistor (HBT) technology has become a major player in wireless communication, power amplifier, mixer, and frequency synthesizer applications. HBTs extend the advantages of silicon bipolar transistors to significantly higher frequencies. Since the mid-1980s, HBT technology development has focussed on reducing cost and improving reliability which, in turn, led to numerous commercial products, such as prescalers, gate arrays, digital-to-analog converters, mux/demux chip sets, logarithmic amplifiers, RF chip sets for CDMA wireless communication systems, and power amplifiers for cellular communications. They have become a natural choice for very high frequency military applications requiring a high current drive, high transconductance, high voltage handling capability, low noise oscillator, and uniform threshold voltage. Emerging HBT technologies allow the integration of a large quantity of high performance RF circuits and high speed digital circuits on a single chip. This paper provides an overview of HBT device reliability issues.
Noise Sources from a Cylindrical Cavity (2007)

This paper was published as Proceedings of the 13th CEAS/AIAA Aeroacoustics Conference, Rome, Italy, 21-23 May 2007, pp. 1-12. It is also available from http://www.aiaa.org/
SAR Studies for a New Class of Antibacterial NAD Biosynthesis Inhibitors (2009)

A new lead class of antibacterial drug-like NAD synthetase (NADs) inhibitors was previously identified from a virtual screening study. Here a solution-phase synthetic library of 76 compounds, analogs of the urea-sulfonamide 5838, was synthesized in parallel to explore SAR on the sulfonamide aryl group. All library members were tested for enzyme inhibition against NADs and nicotinic acid mononucleotide adenylyltransferase (NaMNAT), the last two enzymes in the biosynthesis of NAD, and for growth inhibition in a Bacillus anthracis antibacterial assay. Most compounds that inhibited bacterial growth also showed inhibition against one of the enzymes tested. While only modest enhancements in the enzyme inhibition potency against NADs were observed, of significance was the observation that the antibacterial urea-sulfonamides more consistently inhibited NaMNAT.
Bifunctional, Conjugated Oligomers for Orthogonal Self-Assembly:  Selectivity Varies from Planar Substrates to Nanoparticles (2004)

A diphenylacetylene containing two different end groups (isonitrile and thioacetate) was synthesized, showing that the chemistry used to install each end group is compatible with that of the others. The isonitrile group binds preferentially to platinum, and the thiol group binds preferentially to gold. However, the selectivity was different when nanoparticles were compared to planar substrates.
In Vitro Antimalarial Activity of a New Organometallic Analog, Ferrocene-Chloroquine (1998)

The in vitro activities of new organometallic chloroquine analogs, based on 4-amino-quinoleine compounds bound to a molecule of ferrocene, were evaluated against chloroquine-susceptible, chloroquine-intermediate, and chloroquine-resistant, culture-adapted Plasmodium falciparum lineages by a proliferation test. One of the ferrocene analogs totally restored the activity of chloroquine against chloroquine-resistant parasites. This compound, associated with tartaric acid for better solubility, was highly effective. The role of the ferrocene in reversing chloroquine resistance is discussed, as is its potential use for human therapy.
Ready oxidation of halides to aldehydes using trimethylamine N-oxide in dimethylsulfoxide (1990)

The combination of anhydrous trimethylamine N-oxide in dimethylsulfoxide rapidly oxidizes a variety of alkyl and allylic halides to aldehydes in very good yield at or below room temperature.
Second-harmonic generation by resonant high-index dielectric nanoparticles (2017)

By combining analytical and numerical approaches, we study resonantly enhanced second-harmonic (SH) generation by individual high-index dielectric nanoparticles made of centrosymmetric materials. Considering both bulk and surface nonlinearities, we describe second-harmonic nonlinear scattering from a silicon nanoparticle optically excited in the vicinity of the magnetic and electric dipole resonance. We discuss the contributions of different nonlinear sources and the effect of the lowest-order optical Mie modes on the characteristics of the generated far-field. Our findings uncover important implications for design of nonlinear nanoantennas fully integrable with silicon-based photonic circuits.
Functional Analysis of Adenovirus Protein IX Identifies Domains Involved in Capsid Stability, Transcriptional Activity, and Nuclear Reorganization (2001)

The product of adenovirus (Ad) type 5 gene IX (pIX) is known to actively participate in the stability of the viral icosahedron, acting as a capsid cement. We have previously demonstrated that pIX is also a transcriptional activator of several viral and cellular TATA-containing promoters, likely contributing to the transactivation of the Ad expression program. By extensive mutagenesis, we have now delineated the functional domains involved in each of the pIX properties: residues 22 to 26 of the highly conserved N-terminal domain are crucial for incorporation of the protein into the virion; specific residues of the C-terminal leucine repeat are responsible for pIX interactions with itself and possibly other proteins, a property that is critical for pIX transcriptional activity. We also show that pIX takes part in the virus-induced nuclear reorganization of late infected cells: the protein induces, most likely through self-assembly, the formation of specific nuclear structures which appear as dispersed nuclear globules by immunofluorescence staining and as clear amorphous spherical inclusions by electron microscopy. The integrity of the leucine repeat appears to be essential for the formation and nuclear retention of these inclusions. Together, our results demonstrate the multifunctional nature of pIX and provide new insights into Ad biology.
MUC1 and colorectal cancer pathophysiology considerations (2008)

Several lines of evidence point towards a biological role of mucin and particularly MUC1 in colorectal cancer. A positive correlation was described between mucin secretion, proliferation, invasiveness, metastasis and bad prognosis. But, the role of MUC1 in cancer progression is still controversial and somewhat confusing. While Mukherjee and colleagues developed MUC1-specific immune therapy in a CRC model, Lillehoj and co-investigators showed recently that MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism. In carcinoma cells the polarization of MUC1 is lost and the protein is over expressed at high levels over the entire cell surface. A competitive interaction between MUC1 and E-cadherin, through beta-catenin binding, disrupts E-cadherin-mediated cell-cell interactions at sites of MUC1 expression. In addition, the complex of MUC1-beta-catenin enters the nucleus and activates T-cell factor/leukocyte enhancing factor 1 transcription factors and activates gene expression. This mechanism may be similar to that just described for DCC and UNC5H, which induced apoptosis when not engaged with their ligand netrin, but mediate signals for proliferation, differentiation or migration when ligand bound.
A state-space approach to adaptive filtering (1993)

The authors describe a unified square-root-based derivation of adaptive filtering schemes that is based on reformulating the original problem as a state-space linear least-squares estimation problem. In this process one encounters rich connections with algorithms that have been long established in linear least-squares estimation theory, such as the Kalman filter, the Chandrasekhar filter, and the information forms of the Kalman and Chandrasekhar algorithms. The RLS (recursive least squares), fast RLS, QR, and lattice algorithms readily follow by proper identification with such well-known algorithms. The approach also suggests some generalizations and extensions of classical results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
TomoPy: a framework for the analysis of synchrotron tomographic data (2014)

Analysis of tomographic datasets at synchrotron light sources (including X-ray transmission tomography, X-ray fluorescence microscopy and X-ray diffraction tomography) is becoming progressively more challenging due to the increasing data acquisition rates that new technologies in X-ray sources and detectors enable. The next generation of synchrotron facilities that are currently under design or construction throughout the world will provide diffraction-limited X-ray sources and are expected to boost the current data rates by several orders of magnitude, stressing the need for the development and integration of efficient analysis tools. Here an attempt to provide a collaborative framework for the analysis of synchrotron tomographic data that has the potential to unify the effort of different facilities and beamlines performing similar tasks is described in detail. The proposed Python-based framework is open-source, platform- and data-format-independent, has multiprocessing capability and supports procedural programming that many researchers prefer. This collaborative platform could affect all major synchrotron facilities where new effort is now dedicated to developing new tools that can be deployed at the facility for real-time processing, as well as distributed to users for off-site data processing.
Beta-cell function improved by supplementing basal insulin secretion in mild diabetes. (1976)

Insulin supplements, predominantly as a constant basal fish insulin infusion, were given to patients with mild diabetes to reduce the overnight fasting glucose level to normal. The basal plasma human insulin levels were reduced to subnormal levels by the infusion, and the insulin response to intravenous glucose was enhanced. The beta-cell in diabetes seems to be in a vicious circle in which an impaired insulin response to glucose produces hyperglycaemia, which stresses beta-cell function, making it more inefficient. A constant basal insulin supplement to induce basal normoglycaemia may benefit beta-cell function in diabetes.
[Cytokines and solid tumors]. (1993)

Various cytokines can be used in the treatment of solid tumours. They are factors of proliferation and/or differentiation of haematopoiesis or immunopoiesis, and they stimulate the effector cells of anti-tumoral response. The various steps in the preclinical and clinical development of a cytokine in the field of oncology are detailed, taking IL-2 as an example. The results of the clinical trials reported (essentially with INF and IL-2) are presented and discussed.
Effect of dietary L-carnitine on growth, carcass characteristics, and metabolism of swine (1996)

Thirty six Yorkshire gilts (initially 123 lb BW) were used to investigate the effect of dietary carnitine on growth performance, carcass characteristics, fatty acid oxidation, and enzyme kinetics. Dietary carnitine reduced fat deposition in favor of protein deposition, stimulated fatty acid oxidation, induced the expression of pyruvate carboxylase, increased the capacity of pyruvate carboxylase flux, and decreased the capacity of branch chain keto-dehydrogenase.; Swine Day, Manhattan, KS, November 21, 1996
The plant kingdom as a source of anti-ulcer remedies (2000)

Phytogenic agents have traditionally been used by herbalists and indigenous healers for the prevention and treatment of peptic ulcer. This article reviews the anti-acid/anti-peptic, gastro-protective and/or anti-ulcer properties of the most commonly employed herbal medicines and their identified active constituents. Botanical compounds with anti-ulcer activity include flavonoids (i.e. quercetin, naringin, silymarin, anthocyanosides, sophoradin derivatives) saponins (i.e. from Panax japonicus and Kochia scoparia), tannins (i.e. from Linderae umbellatae), gums and mucilages (i.e. gum guar and myrrh). Among herbal drugs, liquorice, aloe gel and capsicum (chilli) have been used extensively and their clinical efficacy documented. Also, ethnomedical systems employ several plant extracts for the treatment of peptic ulcer. Despite progress in conventional chemistry and pharmacology in producing effective drugs, the plant kingdom might provide a useful source of new anti-ulcer compounds for development as pharmaceutical entities or, alternatively, as simple dietary adjuncts to existing therapies.