gebhart/patrepeval huggingface dataset:
Prediction of wind effects on buildings using computational methods — review of the state of the art (1994)

Advancements in computer software and hardware technology provide a new direction for analyzing engineering problems. Recently the field of wind engineering has gained significant momentum in the computer modelling process. This paper reviews the state of the art in computational wind engineering, including the finite element method, finite difference method, and control volume technique. A portion of this paper summarizes the research in this area carried out by the authors. Computations have been made for a variety of building configurations, including normal wind flow conditions for a building with different aspect ratios, and modelling wind environmental conditions around groups of buildings. The computer modelling technique may eventually enhance the design of buildings and structures against wind loading and supplement the current design practice of using building codes and standards or performing experiments in wind tunnels. Key words: buildings, computer modelling, pressure, velocity, wind engineering, wind tunnels.
Immunogenicity of a Vaccine Preparation Representing the Variable Regions of the HIV Type 1 Envelope Glycoprotein (2000)

Variability of the major antigenic sites of the envelope glycoprotein of HIV-1 constitutes a major problem in the formulation of effective vaccines. We have prepared a synthetic peptide vaccine that represents the major hypervariable epitopes (V1 through V5) of the clade B HIV-1 envelope glycoprotein (gp120). We refer to this preparation as variable epitope immunogen or VEI vaccine. This construct takes into consideration the type and frequency of amino acid substitutions found at each epitope during the evolution of the virus in individual patients and in the target population. Immunization of mice, rabbits, and rhesus macaques with the VEI vaccine resulted in the induction of long-lasting, high-titered HIV-1 antibodies, including antibodies that neutralize primary isolates. We also documented lymphocyte proliferative responses to the VEI vaccine, its individual components, analogs, and subtype-specific peptides representing the major hypervariable regions of HIV-1 gp120. Delayed-type hypersensitivity responses to these antigens were also demonstrated in mice. Our results show that this vaccine is highly immunogenic and safe in animals. Our data suggest that this formulation could become an important component of combination vaccine approaches against HIV-1 and other antigenically variable pathogens.
Genome Sequence of Lactobacillus fermentum Strain NCC2970 (CNCM I-5068) (2016)

Lactobacillus fermentum NCC2970 (CNCM I-5068) is a lactic acid bacterium originating from the Nestle Culture Collection. Here, we disclose its full 1.9-Gb genome sequence comprising one chromosome with no plasmid.
Sequential α‐Ketoacid‐Hydroxylamine (KAHA) Ligations: Synthesis of C‐Terminal Variants of the Modifier Protein UFM1 (2012)

3 for 3: Sequential α-ketoacid–hydroxylamine (KAHA) ligations with 5-oxaproline allow access to the modifier protein UFM1 (Ubiquitin-fold modifier 1) with a C-terminal amide, carboxylic acid, or a masked thioester. Fmoc protection of an N-terminal 5-oxaproline permits the assembly of proteins of >80 residues in good yield by a two-pot process from three readily prepared medium-sized protein segments. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Millimeter-Scale Fuel Cell With Onboard Fuel and Passive Control System (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We report microfabrication of a millimeter-scale fuel cell with onboard fuel and a passive control mechanism. This unique power source has a total volume of 9 <formula formulatype="inline"><tex Notation="TeX">$\mu\hbox{L}\break(3 \times 3 \times 1\ \hbox{mm}^{3})$</tex></formula>, which makes it the smallest fully integrated fuel cell reported in the literature. The first generation of this device delivered an energy density of 254 <formula formulatype="inline"> <tex Notation="TeX">$\hbox{W} \cdot \hbox{h/L}$</tex></formula>. The device uses a reaction between a metal hydride, <formula formulatype="inline"><tex Notation="TeX">$\hbox{LiAlH}_{4}$</tex></formula>, and water vapor to generate hydrogen in a reactor. The generated hydrogen exits the reactor through a nanoporous silicon wall to reach a hybrid silicon/Nafion membrane electrode assembly. A passive microfluidic control system regulates hydrogen generation through controlled delivery of water vapor to the metal hydride based on the reactor pressure. The development of this unique power source greatly benefits the portable electronics industry and enables future technologies that require significantly high energy density power sources such as cognitive arthropods (“thinking” insect-sized robots). This paper provides details of the device microfabrication processes, component integration, and performance analysis. <formula formulatype="inline"><tex Notation="TeX">$\hfill\hbox{[2008-0168]}$</tex></formula> </para>
Interferometer for measuring the surface shape of a ball bearing raceway (1985)

A new type of interferometric measuring technique has been developed to make precise measurements of periphery surface shapes, such as toroidal surfaces and raceway surfaces of bearings. The measuring apparatus consists of a Fizeau interferometer, a rotating air spindle unit, and a microcomputer system. The raceway shape along the cross section is measured at each rotating angle until the entire surface data are stored in the computer memory. The fringe data at each angle are displayed two dimensionally using a TV frame memory to obtain a peri-interferogram. The surface of a 6203 inner ball bearing raceway can be measured successfully with an accuracy of within 100 nm.
Pharmacologic strategies in the treatment of experimental spinal cord injury. (1992)

Remarkable advances have been made in pharmacologic treatments of acute and chronic spinal cord injury. The recent National Acute Spinal Cord Injury Study (NASCIS) showed that very high dose methylprednisolone given within 8 hr after injury improves neurologic recovery. The mechanism is believed to be inhibition of lipid peroxidation. Many other drugs have been claimed to be beneficial in animal studies, including other lipid peroxidation inhibitors, free radical scavengers, opiate receptor blockers, NMDA receptor blockers, calcium channel blockers, inhibitors of arachidonic acid metabolism, and protease inhibitors. In chronic spinal cord injury, much progress also has been made. Myelin was found to possess factors that inhibit axonal regeneration. Blocking these factors enhances spinal cord regeneration. Monosialic gangliosides (GM1) were recently found to improve neurologic recovery in spinal-cord-injured patients. Given as late as 48-72 hr after injury, the mechanism of action is not well understood. However, the GM1 results give hope that recovery mechanisms can be manipulated pharmacologically. Nonregenerative therapy for chronic spinal cord injury is also being developed. Several drugs, including 4-aminopyridine and baclofen, respectively blockers of potassium channels and GABA-B receptors, improve conduction in demyelinated axons. These drugs may be useful for identifying patients who might benefit from remyelination therapy. Finally, NASCIS has complicated acute spinal cord injury studies. To bring a drug to clinical trial, an investigator must now determine the optimal treatment dose, timing, and duration over a range of injury severities, in comparison and combination with methylprednisolone. This requirement has so increased the scale of drug testing that multicenter laboratory trials may be necessary.
In vitro engineering of human skin-like tissue (1998)

Coverage of large, full-thickness burns presents a challenge for the surgeon due to the lack of availability of the patient's own skin. Currently, tissue engineering offers the possibility of performing a suitable therapeutic wound coverage after early burn excision by using cultured keratinocyte sheets supported by a dermal layer. The aim of this study was to develop and characterize a skin substitute composed of both epidermal and dermal elements. For this purpose we grew keratinocytes and fibroblasts separately for 15 days within two different types of biomaterials. Cells then were co-cultured for an additional period of 15 days, after which samples were taken and processed with either classic or immunohistochemical stainings. Results showed that (1) human fibroblasts and keratinocytes can be cultured on hyaluronic acid-derived biomaterials and that (2) the pattern of expression of particular dermal-epidermal molecules is similar to that found in normal skin. The data from this study suggest that our skin equivalent might be useful in the treatment of both burns and chronic wounds.
Quantum statistics of the gain-narrowed Raman linewidth in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">H</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (1990)

Recent studies have shown that single-shot spectra in stimulated Raman scattering can be much narrower than the quantum-mechanical gain-narrowed linewidth. However, shot-to-shot fluctuations in the single-shot spectra are such that the ensemble average gives the gain-narrowed linewidth. This happens because the mean frequencies of the single-shot spectra fluctuate from shot to shot under the gain-narrowed linewidth, and because some ``noisy'' shots are broadened or display multipeaked spectra. The nature of these quantum-noise-initiated fluctuations will be discussed in this paper, with both numerical and experimental results presented. Noisy, multipeaked, single-shot spectra will be shown to have a broader distribution of mean frequencies than the distribution of near-Fourier-transform-limited spectra.
The effects of finite sampling in spin‐echo or field‐echo magnetic resonance imaging (1987)

The artifacts associated with finite sampling in magnetic resonance imaging are shown to be significant when the ratio of half the sampling time, Ts/2, to transverse relaxation time, T2, is on the order of unity or greater. For both symmetric and asymmetric sampling, these artifacts include enhanced high spatial frequency image intensity (bright edges), induced systematic noise, loss of resolution, and changes in phase. Simple filtering of the raw data does not remove the problem in tissues with position-dependent T2 values. An exact deconvolution method is described to remove these problems associated with finite position-dependent T2 values.
A Hybrid Ensemble Scheme for Diagnosing New Class Defects under Non-stationary and Class Imbalance Conditions (2017)

Strategic necessities to design and implement practical diagnostic systems are the abilities of incremental learning and diagnosing new class defects under non-stationary and class imbalance conditions. In this work, a hybrid ensemble scheme, named Learn++NCS, is adopted for diagnosing bearing defects in induction motors. This diagnostic scheme includes a feature extraction module and a hybrid ensemble scheme. The former intends to extract discriminant features from the vibrational signals. The latter collects various class imbalance sets of samples chunk by chunk from a non-stationary environment, constructs a hybrid ensemble by means of a consultation and voting mechanism, incrementally learns novel features-defects relations and diagnoses new class defects. Experimental results present the effectiveness of the proposed hybrid scheme.
Prospective analysis of the epidermal growth factor receptor gene mutations in non-small cell lung cancer in Japan (2006)

7077 Background: Previous clinical trials have revealed that gefitinib is more likely to be effective in non-small cell lung cancer (NSCLC) with activating somatic mutations of epidermal growth factor receptor (EGFR). Most of those reports evaluated NSCLC patients who had post-operative recurrence and then received gefitinib retrospectively using their surgical specimens. However, many NSCLC patients are inoperable at diagnosis. Thus we conducted this study to examine EGFR mutation status by diagnostic tumor samples before gefitinib treatment and investigate the correlation between EGFR mutation and the efficacy of gefitinib. Methods: We prospectively evaluated various tumor samples obtained from NSCLC patients who had never received gefitinib for EGFR mutations in exon 18–23. For patients treated with gefitinib after the examination of EGFR mutations, the response to gefitinib was also evaluated. Results: From June 2004 to November 2005, 91 patients with advanced or post-operative recurrent NSCLC enrolled onto this study and 104 tumor samples were obtained from transbronchial biopsies, effusions, as well as surgical specimens. Thirty-two mutations including deletions in exon 19 in 23 patients and L858R in 9 patients were detected among those 91 patients; 30 in 81 adenocaricinoma, 1 in 2 adenosquamous cell carcinoma, and 1 in 5 large cell carcinoma. The mutations were found more frequently in female (51.9%) than male (12.8%), in never smoker (52.0%) than smoker (14.6%). Response rate of gefitinib in patients with EGFR mutations was 65.0% (13 of 20) compared to 37.5% (3 of 8) in patients without mutations. Among 7 patients with EGFR mutations who were examined multiple tumor samples, 3 had the discrepancy of EGFR gene status between different samples obtained at different time points, suggesting genetic heterogeneity of their tumors. The EGFR status of the most recent samples is likely to be correlated to the response to gefitinib. Conclusions: The EGFR mutation analysis was possible not only from surgical specimens but also from daily available diagnostic samples. For patients with EGFR mutations, gefitinib could achieve a promising high response rate. We propose to examine the most recent tumor samples to predict the sensitivity to gefitinib reliably. No significant financial relationships to disclose.
Progress toward a simplified polymerase chain reaction and its application to diagnosis of tuberculosis (1993)

The complexity, expense, and susceptibility to contamination of the polymerase chain reaction (PCR) are all issues which need to be overcome if PCR is to be used outside of research laboratories. We addressed these problems with respect to the diagnosis of tuberculosis. First, we simplified the procedure for extracting Mycobacterium tuberculosis DNA from sputum samples. Two methods of sample preparation were compared: the chaotrope-silica method and a novel, more simple chloroform method. Second, we developed a colorimetric method for product detection. This method was as sensitive and specific as agarose gel electrophoresis for detection of PCR product. By using a one-tube nested protocol, 5 to 50 genome equivalents of M. tuberculosis DNA were detected. The simplified colorimetric PCR was compared with microscopy and culture for detection of M. tuberculosis in clinical specimens of sputum. A total of 171 sputum samples were investigated from 108 patients, 12 of whom were subsequently found to have tuberculosis by culture and/or microscopy. PCR of samples prepared by the chaotrope-silica method had a sensitivity of 75% and a specificity of 100% whereas PCR of samples prepared by the chloroform method had a sensitivity of 92% and a specificity of 99% when compared with the sensitivities and specificities of the combined classical microbiological methods for the diagnosis of tuberculosis. The simplified colorimetric PCR in combination with the chloroform sample preparation method was at least as sensitive as microscopy but had a greater specificity because samples with atypical mycobacteria were not detected by PCR. The sensitivity of the method for detection of smear-negative and extrapulmonary tuberculosis remains to be investigated.
The Selective Class I PI3K Inhibitor CH5132799 Targets Human Cancers Harboring Oncogenic <i>PIK3CA</i> Mutations (2011)

CH5132799 is a selective class I PI3K inhibitor with potent antitumor activity against tumors harboring the PIK3CA mutations. Prediction of CH5132799 response on the basis of PIK3CA mutations could enable patient stratification in clinical settings.
5'-O-Phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity (1990)

5'-O-Phosphonomethylation of different pyrimidine 2',3'-dideoxynucleosides was accomplished by reaction of the latter with diethyl [(p-toylsulfonyl)oxy]methanephosphonate (1) in the presence of sodium hydride. The base-phosphonomethylated (15-19) and sugar-phosphonomethylated (8-12) derivatives could be readily distinguished by 1H and 13C NMR and MS analysis. Protection of the uracil or thymine residue with a N3-benzoyl group failed to prevent base modification. However, O4-methyl-protected 2',3'-dideoxyuridine readily afforded the 5'-O-phosphonomethylated derivative 12, which was converted to both the 2',3'-didoxyuridine analogue 27 and the 2',3'-dideoxycytidine counterpart 29. The 5'-O-phosphonomethyl derivatives of 3'-deoxythymidine (23), 2',3'-dideoxyuridine, (27), 2',3'-dideoxycytidine (29), 3'-O-methylthymidine (26), and 3'-amino-3'-deoxythymidine (28) did not show an appreciable anti-HIV activity in MT-4 cells. In contrast, the 5'-O-phosphonomethyl derivatives of 3'-deoxy-3'-fluorothymidine (24) and 3'-azido-3'-deoxythymidine (25) inhibited HIV-1 cytopathogenicity by 50% at a concentration of approximately 1 microM.
<b>Spinal Cord Stimulation for the Treatment of Refractory Angina Pectoris:</b> A Two‐Year Follow‐Up (1999)

Twenty-three patients affected by severe, refractory angina were submitted to permanent spinal cord stimulation (SCS) and then followed in our outpatient clinic for 24 months. During the follow-up period, the number of weekly angina episodes drastically dropped from 9.2 (preimplant) to 1.8 in the 3rd, 2.5 in the 6th, 4.5 in the 12th, and 4.2 in the 24th month, with a statistically significant difference (P < 0.01) between the first and last values. A significant increase in the average exercise time from 320 +/- 120 seconds (in baseline condition) to 410 +/- 115 seconds (during SCS) was observed at the treadmill stress test (P < 0.01). SCS was well tolerated by all the patients. However, 7 patients died during follow-up (3 myocardial infarctions, 2 noncardiac deaths, and 2 sudden deaths). Three generators were replaced because of battery depletion after 15, 17, and 21 months. No serious complication was observed. In conclusion, in patients with otherwise intractable angina or already submitted to myocardial revascularization, SCS is very effective in reducing the number of angina episodes. The time of the work during exercise stress test is also significantly prolonged.
Feline hyperthyroidism and chronic kidney disease (2015)

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A NOVEL METHOD FOR MAGNETIC RESONANCE BRAIN IMAGE CLASSIFICATION BASED ON ADAPTIVE CHAOTIC PSO (2010)

Automated and accurate classification of magnetic resonance (MR) brain images is an integral component of the analysis and interpretation of neuroimaging. Many different and innovative methods have been proposed to improve upon this technology. In this study, we presented a forward neural network (FNN) based method to classify a given MR brain image as normal or abnormal. This method first employs a wavelet transform to extract features from images, and then applies the technique of principle component analysis (PCA) to reduce the dimensions of features. The reduced features are sent to an FNN, and these parameters are optimized via adaptive chaotic particle swarm optimization (ACPSO). K-fold stratified cross validation was used to enhance generalization. We applied the proposed method on 160 images (20 normal, 140 abnormal), and found that the classification accuracy is as high as 98.75% while the computation time per image is only 0.0452 s.
Continuous Positive Airway Pressure for Treatment of Postoperative Hypoxemia (2005)

Continuous positive airway pressure may decrease the incidence of endotracheal intubation and other severe complications in patients who develop hypoxemia after elective major abdominal surgery.
Evaluation of the Influence of Stainless Steel and Copper on the Aging Process of Bio-Oil (2006)

The thermal stability of bio-oils obtained from softwood bark (SWBR) and hardwood rich in fibers (HWRF) residues was studied under aging conditions at 80 °C in sealed glass bottles in the presence of stainless steel and copper. SWBR-derived bio-oil separated into oily and aqueous phases during aging, while HWRF-derived oil remained as a single phase during the entire aging period. Dynamic rheological tests and GPC analyses were used to follow the effect of aging on the properties of bio-oils. Bio-oil aging was determined following the changes in bio-oil macrofractions using solvents of different polarities. The main difference observed between the oils analyzed was the tendency of SWBR to form materials insoluble in methanol, while HWRF aging reactions led to the formation of compounds insoluble in water and CH2Cl2. Methanol-insoluble and water-/CH2Cl2-insoluble fractions of aged oils were characterized by thermogravimetry, GPC, and Py−GC/MS techniques. The bio-oil aging reactions seem not to be affected by the presence of metals.
Characterization of the C-terminal extension of carboxysomal carbonic anhydrase from <i>Synechocystis</i> sp. PCC6803 (2002)

Sequence analysis of the carboxysomal carbonic anhydrase (CcaA) from Synechocystis PCC6803, Synechococcus PCC7942 and Nostoc ATCC29133, indicated high sequence identity to the β class of plant and bacterial carbonic anhydrases (CA), and conservation of the active site region. However, the cyanobacterial enzyme has a C-terminal extension of about 75 amino acids (aa) not found in the plant enzymes, and largely absent from other bacterial enzymes. Using recombinant DNA technology, genes encoding C-terminal truncation products of up to 127 aa were overexpressed in E. coli, and partially purified lysates were analysed for CA-mediated exchange of <sup>18</sup>O between <sup>13</sup>C<sup>18</sup>O2and H2<sup>16</sup>O. Recombinant CcaA proteins with up to 60 aa removed (CcaAΔ60) were catalytically competent, but beyond this there was an abrupt loss of activity. CcaAΔ0, along with CcaAΔ40 and CcaAΔ60, also catalysed the hydrolysis of carbon oxysulfide (COS; an isoelectronic structural analogue of CO2), but CcaAΔ63 and CcaAΔ127 did not, indicating that truncations greater than 62 aa resulted in a general loss of catalytic competency. Analysis of protein-protein interaction using the yeast two-hybrid system revealed that CcaA did not interact with the large or small Rubisco subunits (RbcL and RbcS, respectively) of Synechocystis, but there was strong CcaA-CcaA interaction. This protein interaction also ceased with C-terminal truncations in CcaA greater than 60 aa. The correlation between loss of CcaA-CcaA interaction and CcaA catalytic activity suggests that the proximal portion of the C-terminal extension is required for oligomerization, and that this oligomerization is essential for catalysis by the cyanobacterial enzyme. Thus, the C-terminal extension may play an important role in the function of CA within cyanobacterial carboxysomes, which is not required by the higher plant enzymes.