gebhart/patrepeval huggingface dataset:
In vitro stimulation of murine lymphoid cell cultures by levamisole. (1975)

Levamisole has been reported to act as an immunological adjuvant. Experiments reported here on the effect of this agent on a variety of murine lymphoid culture systems were designed to gain an insight into its mechanism of action. We have found levamisole to be a weak mitogen for mouse spleen cells producing a dose related response which peaks at 48 hr in culture. The drug acted to augment the response of spleen cells to sub-optimal concentrations of concanavalin A, but had no unusual effect on the lipopolysaccharide stimulation of B-cell DNA synthesis in vitro. Levamisole was directly stimulatory on enriched T-cell populations and was found to have two actions: (1) to stimulate a subpopulation of T cells and (2) to augment the response of suboptimal mitogen concentrations of concanavalin A. In addition, we have found that murine thymocytes stimulated by concanavalin A were greatly potentiated in the presence of levamisole, but this population of cells could not be stimulated directly by the drug.
Reconfigurable optical inter-channel interference mitigation for spectrally overlapped QPSK signals using nonlinear wave mixing in cascaded PPLN waveguides (2016)

A reconfigurable all-optical inter-channel interference (ICI) mitigation method is proposed for an overlapped channel system that avoids the need for multi-channel detection and channel spacing estimation. The system exhibits a 0.5-dB implementation penalty compared to a single-channel baseline system. Experiments using a dual-carrier QPSK overlapped system with both 20G-baud and 25G-baud under different channel spacing conditions evaluate the performance of the method. Improved signal constellation and receiver sensitivity demonstrate the effectiveness of this approach. This results in over 4-dB OSNR of benefit when the system Q-factor reaches a forward error correction (FEC) threshold of 8.5 dB under less-than-baudrate channel spacing conditions.
Chemical Structure and Some Properties of Roseoflavin (1975)

Abstract Roseoflavin (I) is identified as 7-methyl-8-dimethylamino-10-(1′-d-ribityl)-isoalloxazine (IX) by comparing I with four diastereoisomers of 7-methyl-8-dimethylamino-10-d-n-pentitylisoalloxazine, which were synthesized from 2-dimethylamino-4-amino-toluene, d-pentoses, and violuric acid. The coincidence of chemical and physical properties—elemental analysis, UV-visible absorption spectrum, melting point, optical rotation, Rf value in thin layer chromatography, and NMR spectrum—of free and acetylated I with those of the free and acetylated IX, respectively, verified the identity. Some of the properties of I and acetylated I (pKa, oxidation-reduction, absorption spectra, and extinction coefficients of various ionic species, and photosensitivity) are also described.
Velocity Estimation by Using Position and Acceleration Sensors (2007)

Knowledge of velocity is crucial to certain industrial applications involving high-bandwidth modeling and control. In conventional approaches, the velocities obtained from encoders or tachometers are quite noisy, and low-pass filters are usually engaged to generate usable velocity signals. The low-pass filter, however, causes significant phase lag that can severely affect both modeling and control accuracy in the mid- and high-frequency ranges. In this paper, two approaches using a combination of an encoder and an imperfect accelerometer are proposed to estimate velocities with high bandwidth. The two approaches, namely the two-channel approach and the observer-based approach, estimate velocities by applying proper frequency weightings to the encoder and accelerometer signals. The encoder mainly contributes to the low-frequency components of velocity estimation, and the accelerometer mainly contributes to the high-frequency components of velocity estimation. An adaptive mechanism for estimating the accelerometer gain is also presented. The effectiveness of the two velocity estimation approaches is verified experimentally with respect to a one-degree-of-freedom robot performing both rigid contact modeling and control. Extension to 3-D applications is discussed.
RICK Activates a NF-κB-dependent Anti-human Cytomegalovirus Response (2004)

The adapter kinase receptor interacting protein-like interacting caspase-like apoptosis regulatory protein kinase (RICK, also called RIP2 and CARDIAK) was found to be elevated at both the protein and RNA levels during human cytomegalovirus (HCMV) replication, suggesting either that the virus may require RICK for replication or that RICK is part of an unsuccessful host attempt to inhibit HCMV replication. It is demonstrated here that forced expression of RICK in either a kinase active or inactive form activates nuclear factor (NF)-kappaB by means of its intermediate domain and potently blocks HCMV replication in human fibroblasts. Importantly, NF-kappaB activation, which exerted a modestly positive effect on the early phase of infection, clearly had a strongly negative impact during later viral steps. A stable inhibitor of NF-kappaB (IkappaB) reverses the RICK inhibitory effect, and activation of NF-kappaB by IkappaB kinase beta expression is inhibitory to HCMV, demonstrating that NF-kappaB activation is part of a potent anti-HCMV response. Supernatant transfer experiments identified interferon-beta as a downstream component of the RICK inhibitory pathway. RICK expression was found to synergize with HCMV infection in the induction of interferon-beta expression. This study identifies an endogenous RICK-activated, NF-kappaB- and interferon-beta-dependent antiviral pathway that is either inhibited or faulty under normal HCMV replication conditions; efforts to bolster this pathway may lead to novel anti-viral approaches.
<title>Optimization Of The Optics Matching A Storage Ring To An X-Ray Lithography Camera</title> (1984)

An oscillating grazing incidence mirror can be used to achieve vertically uniform illumination with a synchrotron radiation source. To increase the intensity it has been suggested previously to use a figured mirror rather than a plane mirror so that light from a larger horizontal angle can be directed into the exposure area. This paper presents results of ray-tracing calculations that show how much the intensity can actually be increased while maintaining good horizontal uniformity. Cylindrical, parabolic and elliptical mirrors are investigated and geometrical parameters are optimized. It is shown further that with an ellipsoid the throughput of a step-and-repeat camera is almost independent of the exposure field size. The parameters of the IBM X-ray lithography beamline are discussed.
NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA (2006)

Nonspecific protein-DNA interactions are inherently dynamic and involve both diffusion of the protein along the DNA and hopping of the protein from one DNA molecule or segment to another. Understanding how gene regulatory proteins interact nonspecifically with DNA in terms of both structure and dynamics is challenging because the experimental observables are an ensemble average of many rapidly exchanging states. By using a variety of NMR spectroscopic techniques, including relaxation analysis, paramagnetic relaxation enhancement, and residual dipolar couplings, we have characterized structural and kinetic aspects of the interaction of the HoxD9 homeodomain with a nonspecific, 24-bp DNA duplex in a system in which the protein is not constrained to any particular site. The data reveal that HoxD9 binds to nonspecific DNA with the same binding mode and orientation as that observed in the specific complex. The mobility, however, of Arg side-chains contacting the DNA is increased in the nonspecific complex relative to the specific one. The kinetics of intermolecular translocation between two different nonspecific DNA molecules have also been analyzed and reveal that at high DNA concentrations (such as those present in vivo) direct transfer from one nonspecific complex to another nonspecific DNA molecule occurs without going through the intermediary of free protein. This finding provides a simple mechanism for accelerating the target search in vivo for the specific site in a sea of nonspecific sites by permitting more effective sampling of available DNA sites as the protein jumps from one segment to another.
GEEC: Scalable, Efficient, and Consistent Consensus for Blockchains. (2018)

Blockchain technology has the potential to deploy broad decentralized applications, greatly improving their security and reliability. Unfortunately, despite much effort, no existing public blockchain protocol can ensure strong consistency with a high efficiency, while reliability of permissioned blockchain relies on consortium members. We present GEEC, a inital blockchain protocol and its runtime system by leveraging the Intel Software Guard eXtentions (SGX) hardware. GEECachieves privacy and security for permissioned blockchains and leveraging Intel SGX. GEEC can append a block with only one and a half network round-trips and two P2P broadcasts. We carry a proof sketch to show that GEEC is strongly consistent.
Theoretical and experimental study of a catadioptric compensator for an aspheric surface (2013)

A new type of catadioptric compensator is established. The tolerance values of lens spacing, lens thickness, and tilt in mounting are about three times higher than that of the Offner compensator. They overcome the localization of the Offner compensator, improve the test validity, and reduce the test risk of system detection by cross-validation with existing means. The performance of the catadioptric compensator is verified in experiments and theoretically.
Early ambulation physical activity: myocardial infarction and coronary artery bypass surgery. (1984)

The accepted pattern of care for the patient recovering from myocardial infarction or coronary bypass surgery in the 1980s is characterized by an earlier resumption of physical activity, a consequent decrease in imposed invalidism, and earlier discharge from the hospital for appropriately selected patients. Early ambulation has been demonstrated to be desirable, feasible, cost-effective, and safe.
A New Rate Control Algorithm based on Statistical Analysis for MVC (2012)

Rate control is one of important tools in multi-view video coding (MVC). This paper presents a new rate control algorithm for MVC by analyzing the rate allocation proportion among different types of views. The proposed algorithm is performed on three levels, that is, view level, group-of-pictures (GOP) level and frame level. Firstly, we reasonably allocate bit-rate among views based on the statistical analysis in the view level. Then, in the GOP level, the initial quantization parameter (QP) of each GOP is set according to the QP values of B frames. Finally, the frame complexity is used to regulate the target bit for each frame. Experimental results show that the proposed algorithm can accurately control bit-rate to satisfy the requirements of multi-view video systems.
Data-driven sparsity-based restoration of JPEG-compressed images in dual transform-pixel domain (2015)

Arguably the most common cause of image degradation is compression. This papers presents a novel approach to restoring JPEG-compressed images. The main innovation is in the approach of exploiting residual redundancies of JPEG code streams and sparsity properties of latent images. The restoration is a sparse coding process carried out jointy in the DCT and. pixel domains. The prowess of the proposed approach is directly restoring DCT coefficients of the latent image to prevent the spreading of quantization errors into the pixel domain, and at the same time using on-line machine-learnt local spatial features to regulate the solution of the underlying inverse problem. Experimental results are encouraging and show the promise of the new approach in significantly improving the quality of DCT-coded images.
A Secure Cloud Enabled Indoor Hydroponic System Via ThingsSentral IoT Platform (2020)

The increase in population and rapid industrial development of a country, especially in urban areas, contributes to various urbanization issues such as housing, food demands, education, health, poverty, etc. An alternative method of farming utilizing minimized land areas with large crop produce is highly sought. This farming method is expected to be operated at a lower cost with easy monitoring of essential plantation necessities such as light, water level, temperature, and humidity. This paper discusses the design and development of an automatic monitoring of an indoor vertical hydroponic system. Three main components will be designed and developed to realize the system. Firstly, an indoor hydroponic module with IoT technology. Secondly, a dashboard for monitoring and managing the operation of the system. Finally, a two-factor authentication mechanism to enhance the security elements of the system. Preliminary results obtained showed promising progress and opportunity for the designed system.
ObjectSkin (2018)

Augmenting everyday objects with interactive input and output surfaces is a long-standing topic in ubiquitous computing and HCI research. Existing approaches, however, fail to leverage the objects' full potential, particularly in highly curved organic geometries and in diverse visuo-haptic surface properties. We contribute ObjectSkin, a fabrication technique for adding conformal interactive surfaces to rigid and flexible everyday objects. It enables multi-touch sensing and display output that seamlessly integrates with highly curved and irregular geometries. The approach is based on a novel water-transfer process for interactive surfaces. It leverages off-the-shelf hobbyist equipment to fabricate thin, conformal, and translucent electronic circuits that preserve the surface characteristics of everyday objects. It offers two methods, for rapid low-fidelity and versatile high-fidelity prototyping, and is applicable to a wide variety of materials. Results from a series of technical experiments provide insights into the supported object geometries, compatible object materials, and robustness. Seven example cases demonstrate how ObjectSkin makes it possible to leverage geometries, surface properties, and unconventional objects for prototyping novel interactions for ubiquitous computing.
[Study of malabsorption of lactose by the hydrogen breath test in a population of 70 Tunisian adults]. (1987)

Lactose malabsorption was studied by the hydrogen breath-test in 23 adults suffering from irritable bowel syndrome (group A) and in 47 healthy subjects (group B). The concentration of hydrogen in end-expired alveolar samples was measured after ingestion of 25 g of lactose. Among the 70 subjects, 6 (8.5 p. 100) were not hydrogen producers and were excluded from the study. Lactose malabsorption was shown in 51 of the remaining 64 subjects (79.6 p. 100). Among these 51 patients, 36 were healthy and 15 had an irritable bowel syndrome. The frequency of lactose malabsorption among the 43 healthy hydrogen producers was 83 p. 100. This value is similar to those observed in other studies (greek and italian). Our results suggest that lactose malabsorption is frequent among the tunisian adult population.
Steroid hormone receptors in human colon cancers (1979)

Tumors from patients with primary colon cancer were studied for the presence of steroid hormone receptors for estrogen (E2), progesterone (Prog), dihydrotestosterone (DHT) and glucocorticoid. Ten of 33 (30%) tumors contained high affinity E2 receptors. Four were males and six females with positive assays predominantly from the left colon. Twenty-three of these tumors were also assayed for DHT and Prog and six (26%) contained all three receptors. An additional twelve tumors had at least one receptor, so that 70% of the tumors studied contained one or more receptors. Five of 22 (23%) samples were positive for glucocorticoid receptors. Common etiological factors associated with colon and breast cancer were briefly discussed. These factors, along with the presence of hormone receptors in primary colon malignancies suggest that some large bowel cancers may be endocrine-dependent.
Nonreciprocal Phase-Shift Composite Right/Left Handed Microstrip Lines Using Ferrite-Rod-Embedded Substrate (2009)

Nonreciprocal phase-shift composite right/left handed transmission lines with small nonreciprocity in the amplitude of the transmission coefficients are proposed. The present structures are composed of a microstrip line periodically loaded with series capacitance and shunt inductance, and a ferrite rectangular rod is embedded in the dielectric substrate just below the center strip. The balanced composite right/left handed transmission line with nonreciprocal phase characteristics is designed. The numerical simulation results validate that the nonreciprocity in magnitude of the transmission coefficients is negligibly small whereas the nonreciprocity in the phase is still kept relatively large for the present configuration.
Development of a broadband underwater sound projector (2002)

An underwater sound projector has been developed for operation over a decade long frequency range. The output of the projector has been designed for 10 kHz to 100 kHz operation on an autonomous underwater vehicle (AUV). The transducer is resonant at 100 kHz but has been designed to deliver high sound pressure levels without impedance or phase instabilities. The transducer features the first successful stacking of 1-3 piezocomposite materials. The selection of the 1-3 piezocomposite materials has resulted in the mode-free sound output while the stacking arrangement permits acoustic operation with twice the sound output at half the resonance frequency of a single layer. The stacking is done mechanically in series and electrically in parallel with the center electrode as the positive plane. Furthermore, the center electrode has been segmented into four individual elements such that combinations of the sectors offer the ability to access nine different apertures.
Proteomic analysis reveals resistance mechanism against biofuel hexane in Synechocystis sp. PCC 6803 (2012)

The study provided the first comprehensive view of the complicated molecular mechanism employed by cyanobacterial model species, Synechocystis to defend against hexane stress. The study also provided a list of potential targets to engineer Synechocystis against hexane stress.
Aspects of Quality in Internet of Things (IoT) Solutions: A Systematic Mapping Study (2019)

Internet of Things (IoT) is an emerging technology that has the promising power to change our future. Due to the market pressure, IoT systems may be released without sufficient testing. However, it is no longer acceptable to release IoT systems to the market without assuring the quality. As in the case of new technologies, the quality assurance process is a challenging task. This paper shows the results of the first comprehensive and systematic mapping study to structure and categories the research evidence in the literature starting in 2009 when the early publication of IoT papers for IoT quality assurance appeared. The conducted research is based on the most recent guidelines on how to perform systematic mapping studies. A set of research questions is defined carefully regarding the quality aspects of the IoT. Based on these questions, a large number of evidence and research papers is considered in the study (478 papers). We have extracted and analyzed different levels of information from those considered papers. Also, we have classified the topics addressed in those papers into categories based on the quality aspects. The study results carry out different areas that require more work and investigation in the context of IoT quality assurance. The results of the study can help in a further understanding of the research gaps. Moreover, the results show a roadmap for future research directions.
Structure of the mouse beta Fc gamma receptor II gene (1991)

We have isolated and deduced the structure of the beta Fc gamma RII gene from the mouse. This gene spans approximately 18 kb of DNA; the structure and nucleotide sequence has been determined and potential regulatory sites identified. This gene is composed of 10 exons that give rise to the beta 1 and beta 2 Fc gamma RII cDNA. Four exons encode the 5' untranslated region and leader sequence, one exon for each Ig-binding domain and membrane-spanning region and three exons encoding the cytoplasmic tail and 3' untranslated region. Analysis of the gene structure indicated that the beta 1Fc gamma RII and beta 2Fc gamma RII arise by differential mRNA splicing when a single 141-bp exon (exon 8) is alternately spliced to give rise to these isoforms. Sequence analysis of 2 kbp upstream of the transcription start site indicated the presence of regulatory elements, including three binding sites for the transcription factor Sp1, and Ap-4 binding site, a tandem glucocorticoid response element, and an overlapping tandem repeat. Furthermore, as in the Thy-1 gene, no CAT or TATA consensus sequences were observed. In addition, sites of methylation that regulate expression of this gene were also located at the 5' end of the gene and within several introns. A large intron located between exons 4 and 5 also contained a series of purine/pyrimidine-rich regions and a potential enhancer sequence.
Asymmetric Dihydroxylation−Haloetherification Strategy for the Synthesis of Tetrahydrofuran-Containing Acetogenins (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTAsymmetric Dihydroxylation−Haloetherification Strategy for the Synthesis of Tetrahydrofuran-Containing Acetogenins†Huiping Zhang, Mohindra Seepersaud, Sheila Seepersaud, and David R. MootooView Author Information Department of Chemistry, Hunter College, 695 Park Avenue, New York, New York 10021 Cite this: J. Org. Chem. 1998, 63, 6, 2049–2052Publication Date (Web):February 27, 1998Publication History Received19 July 1996Published online27 February 1998Published inissue 1 March 1998https://pubs.acs.org/doi/10.1021/jo961367ihttps://doi.org/10.1021/jo961367ibrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views487Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Chemical structure,Enantioselective synthesis,Hydrocarbons,Reaction products Get e-Alerts
ChemInform Abstract: QUINAZOLINES AS INHIBITORS OF DIHYDROFOLATE REDUCTASE PART 1 (1973)

Abstract Es wird eine Reihe von Chinazolinen (I) und Tetrahydrochinazolinen (II) nach bekannten Methoden hergestellt und auf ihre Inhibitorwirkung gegen Dihydrofolsäureester‐Reduktase untersucht.