gebhart/patrepeval huggingface dataset:
Cardiovascular diseases in dental practice. Practical considerations. (2008)

Coronary heart disease is the principal cause of death in the industrialized world. Its most serious expression, acute myocardial infarction, causes 7.2 million deaths each year worldwide, and it is estimated that 20% of all people will suffer heart failure in the course of their lifetime. The control of risk cardiovascular factors, including arterial hypertension, obesity and diabetes mellitus is the best way to prevent such diseases. The most frequent and serious cardiovascular emergencies that can manifest during dental treatment are chest pain (as a symptom of underlying disease) and acute lung edema. Due to the high prevalence and seriousness of these problems, the dental surgeon must be aware of them and should be able to act quickly and effectively in the case of an acute cardiovascular event. In patients with a history of cardiovascular disease, attention must center on the control of pain, the reduction of stress, and the use or avoidance of a vasoconstrictor in dental anesthesia. In turn, caution is required in relation to the antiplatelet, anticoagulant and antihypertensive medication typically used by such patients.
Cost-Effectiveness Analysis of Invasive and Noninvasive Tests in High Risk Patients Treated With Amiodarone After Acute Myocardial Infarction (1998)

Compared with a noninterventional option, amiodarone prescription in all patients with depressed heart rate variability seems to be a more appropriate approach than the alternative based on the combined use of heart rate variability and electrophysiologic study.
Statistical acceleration for animated global illumination (2006)

Global illumination provides important visual cues to an animation, however its computational expense limits its use in practice. In this paper, we present an easy to implement technique for accelerating the computation of indirect illumination for an animated sequence using stochastic ray tracing. We begin by computing a quick but noisy solution using a small number of sample rays at each sample location. The variation of these noisy solutions over time is then used to create a smooth basis. Finally, the noisy solutions are projected onto the smooth basis to produce the final solution. The resulting animation has greatly reduced spatial and temporal noise, and a computational cost roughly equivalent to the noisy, low sample computation.
Human Limbal Mesenchymal Cells Support the Growth of Human Corneal Epithelial Stem/Progenitor Cells (2014)

Human LMCs can substitute 3T3 cells in the expansion of LSCs using the 3-dimensional culture system.
Autonomous Emergency Braking for Vulnerable Road Users (2013)

A simple, but realistic, model of an autonomous emergency brake (AEB) system was studied. Using Matlab, the model was applied to 543 car‐to‐pedestrian and 607 car‐to‐bicyclist real‐world collisions gathered from the highly detailed German In‐Depth Accident Study Pre‐Crash Matrix (GIDAS PCM) and weighted for representativeness. All collisions were to the front of the car. The aim was to investigate how AEB performance was influenced by varying some of the most relevant system parameters. A reference system was predicted to provide very high effectiveness in saving lives and mitigating severe injuries. However, the effectiveness was substantially impaired by imposing restrictions on functionality in darkness and high speeds. Further, effectiveness was highly sensitive to timing of brake activation and deceleration provided by the AEB system. Combining all these restrictions (darkness, high speed, timing and deceleration) led to a tenfold decrease of effectiveness compared to the reference system.
Tribocharging of the magnetic hard disk drive head–disk interface (2002)

As head–disk separation diminishes and the sensitivity of magnetic recording transducers increases, the effects of spurious charge buildup caused by friction become an increasing concern. We have investigated some of the characteristics of tribocharging during frictional contact between head and media typically found in magnetic hard disk drives. From constant velocity tests with an electrically isolated head contacting the laser texture zone, we find that current and voltage are closely related, both undergoing a rapid initial rise followed by a long-term rise. We have found that the long-term rise is controlled by the rate of discharge and that the overall magnitude of both current and voltage is dependent upon the rate of rotation. Additionally, we find that the magnitude of current and voltage increases sequentially from test to test, suggesting that wear is occurring at the interface. We develop models for wear-induced tribocharging and surface potential difference-induced tribocharging and contrast their predictions for charge generations as functions of velocity. These models suggest that wear is the dominant tribocharging mechanism.
Genome-wide identification of imprinted genes in pigs and their different imprinting status compared with other mammals (2020)

Genomic imprinting often results in parent-of-origin specific differential expression of maternally and paternally inherited alleles and plays an essential role in mammalian development and growth. Mammalian genomic imprinting has primarily been studied in mice and humans, with only limited information available for pigs. To systematically characterize this phenomenon and evaluate imprinting status between different species, we investigated imprinted genes on a genome-wide scale in pig brain tissues. Specifically, we performed bioinformatics analysis of high-throughput sequencing results from parental genomes and offspring transcriptomes of hybrid crosses between Duroc and Diannan small-ear pigs. We identified 11 paternally and five maternally expressed imprinted genes in pigs with highly stringent selection criteria. Additionally, we found that the <i>KCNQ1</i> and <i>IGF2R</i> genes, which are related to development, displayed a different imprinting status in pigs compared with that in mice and humans. This comprehensive research should help improve our knowledge on genomic imprinting in pigs and highlight the potential use of imprinted genes in the pig breeding field.
Personal digital assistants to collect tuberculosis bacteriology data in Peru reduce delays, errors, and workload, and are acceptable to users: cluster randomized controlled trial (2008)

A well-designed PDA-based system to collect data from institutions over a large, resource-poor area can significantly reduce delays, errors, and person-hours spent processing data.
Four Types of Data Skew and Their Effect on Parallel Join Performance (1990)

Recent work on parallel joins and data skew has concentrated on algorithm design without considering the causes and characteristics of data skew itself. This paper presents a simple analytic model of data skew and identifies four distinct types: tuple population skew, selectivity skew, hash partition skew and join probability skew. To demonstrate the model, a representative algorithm, the GRACE parallel join algorithm, is analyzed. Results of the analysis indicate that skew effects are substantial, and that they vary greatly with the type of skew. Also, skew effects vary substantially with system and data characteristics such as communications speed, cardinality and selectivity.
Comparison of Four Rapid DNA Extraction Techniques for Conventional Polymerase Chain Reaction Testing of Three Mycobacterium spp. that Affect Birds (2003)

Mycobacteriosis is an avian disease that is most commonly caused by Mycobacterium avium or Mycobacterium genavense. In order to optimize molecular laboratory tests for diagnosing mycobacteriosis in birds, we compared four methods of rapid DNA extraction with isolates of M. avium, M. genavense, and Mycobacterium fortuitum. DNA extraction methods included enzymatic lysis, boiling for 30 min followed by enzymatic lysis, four cycles of freezing and thawing followed by enzymatic lysis, and bead beating followed by enzymatic lysis. The DNA yield and purity for the four methods were evaluated by spectrophotometry and compared. The bead beating with enzymatic lysis technique yielded significantly purer and higher concentrations of extracted DNA compared with other DNA extraction methods. All four methods yielded extraction products for all three organisms that were successfully amplified by polymerase chain reaction (PCR) for a fragment in the 65-kD heat shock protein gene. Subjectively, the PCR amplification products were most abundant for samples extracted by bead beating with enzymatic lysis.
IFN-α regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages (2007)

IL-27 is a novel member of the IL-12 cytokine family. IL-27 has pro- and anti-inflammatory properties, and it controls the responses of adaptive immunity. It promotes the differentiation of naïve Th cells and suppresses the effector functions of Th17 cells. Biologically active IL-27 is a heterodimer composed of EBV-induced gene 3 (EBI3) and p28 proteins. We report that TLR-dependent expression of IL-27 in human macrophages is mediated by IFN-alpha. Stimulation of macrophages with agonists for TLR3 {polyinosinic:polycytidylic acid [poly(I:C)]}, TLR4 (LPS), or TLR7/8 (R848) results in concurrent expression of EBI3 and p28. The p28 expression is inhibited with neutralizing anti-IFN-alpha antibodies. Unlike poly(I:C), LPS, and R848, TLR2 agonist (S)-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser(S)-Lys4-OH trihydrochloride does not stimulate macrophages to produce IFN-alpha, and therefore, it is not able to turn on the expression of p28. There is an IFN-stimulated response element (ISRE) in the p28 gene promoter. IFN-alpha enhances the expression of IFN regulatory factor 1 (IRF-1) in macrophages and induces binding of IRF-1 to the p28 ISRE site. The data provide a mechanistic basis for the IFN-alpha-mediated activation of IL-27. The data emphasize a role of IFN-alpha in immune responses, which rely on the recognition of pathogens by TLRs.
Improving Processability and Efficiency of Resonant TADF Emitters: A Design Strategy (2019)

Abstract A new design strategy is introduced to address a persistent weakness with resonance thermally activated delayed fluorescence (R‐TADF) emitters to reduce aggregation‐caused quenching effects, which are identified as one of the key limiting factors. The emitter Mes 3 DiKTa shows an improved photoluminescence quantum yield of 80% compared to 75% for the reference DiKTa in 3.5 wt% 1,3‐bis( N ‐carbazolyl)benzene. Importantly, emission from aggregates, even at high doping concentrations, is eliminated and aggregation‐caused quenching is strongly curtailed. For both molecules, triplets are almost quantitatively upconverted into singlets in electroluminescence, despite a significant (≈0.21 eV) singlet‐triplet energy gap (Δ E ST ), in line with correlated quantum‐chemical calculations, and a slow reverse intersystem crossing. It is speculated that the lattice stiffness responsible for the narrow fluorescence and phosphorescence emission spectra also protects the triplets against nonradiative decay. An improved maximum external quantum efficiencies (EQE max ) of 21.1% for Mes 3 DIKTa compared to the parent DiKTa (14.7%) and, importantly, reduced efficiency roll‐off compared to literature resonance TADF organic light‐emitting diodes (OLEDs), shows the promise of this design strategy for future design of R‐TADF emitters for OLED applications.
Increased renal fatty acid binding protein in spontaneously hypertensive rats (1988)

The level of renal fatty acid binding protein (FABP) was quantified by a specific radial immunodiffusion method using an antibody to cytosolic FABP in stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY) at 5, 10, 20 and 40 weeks of age. Increased levels were found in the SHRSP medulla, but not in the WKY medulla. The increase occurred in the hypertension development period, reaching a peak at 20 weeks of age. This increase was confirmed by immunoblotting. There was no significant change of FABP in the cortex. To elucidate the mechanism responsible for these changes in the FABP level, three antihypertensive drugs (nicardipine, hydralazine and enalapril) were given to SHRSP at 20 weeks of age for a period of four weeks. Antihypertensive treatment significantly inhibited the development of hypertension and the increase in the medullary FABP level. The differential response of FABP in SHRSP and WKY suggests that this protein may play an important role in the cellular metabolism of fatty acids under the pathological condition of high blood pressure.
Regulation of Airway <i>MUC5AC</i> Expression by IL-1β and IL-17A; the NF-κB Paradigm (2009)

Mucin over-production is one of the hallmarks of chronic airway diseases such as chronic obstructive pulmonary disease, asthma, and cystic fibrosis. NF-kappaB activation in airway epithelial cells has been shown to play a positive inflammatory role in chronic airway diseases; however, the role of NF-kappaB in mucin gene expression is unresolved. In this study, we have shown that the proinflammatory cytokines, IL-1beta and IL-17A, both of which utilize the NF-kappaB pathway, are potent inducers of mucin (MUC)5AC mRNA and protein synthesis by both well-differentiated primary normal human bronchial epithelial cells and the human bronchial epithelial cell line, HBE1. MUC5AC induction by these cytokines was both time- and dose-dependent and occurred at the level of promoter activation, as measured by a reporter gene assay. These effects were attenuated by the small molecule inhibitor NF-kappaB inhibitor III, as well as p65 small-interfering RNA, suggesting that the regulation of MUC5AC expression by these cytokines is via an NF-kappaB-based transcriptional mechanism. Further investigation of the promoter region identified a putative NF-kappaB binding site at position-3594/-3582 in the promoter of MUC5AC as critical for the regulation of MUC5AC expression by both IL-1beta and IL-17A. Chromatin immunoprecipitation analysis confirmed enhanced binding of the NF-kappaB subunit p50 to this region following cytokine stimulation. We conclude that an NF-kappaB-based transcriptional mechanism is involved in MUC5AC regulation by IL-1beta and IL-17A in the airway epithelium. This is the first demonstration of the participation of NF-kappaB and its specific binding site in cytokine-mediated airway MUC5AC expression.
Attenuation Correction in Positron Emission Tomography Using Single Photon Transmission Measurement (1992)

Accurate attenuation correction is essential for quantitative positron emission tomography. Typically, this correction is based on a coincidence transmission measurement using an external source of positron emitter, which is positioned close to the detectors. This technique suffers from poor statistical quality and high dead time losses, especially with a high transmission source strength. We have proposed and tested the use of single photon transmission measurement with a rotating rod source, to measure the attenuation correction factors (ACFs). The singles projections are resampled into the coincidence geometry using the detector positions and the r,)d source location. A nonparalyzable dead time correction algorithm was developed for the block detectors used in the McMaster PET scanner. Transaxial resolution is approximately 6 mm, which is comparable to emission scanning performance. Axial resolution is about 25 mm, with only crude source collimation. ACFs are underestimated by approximately 10% due to increased crossplane scatter, compared to coincidence transmission scanning. Effective source collimation is necessary to obtain suitable axial resolution and improved accuracy. The response of the correction factors to object density is linear to within 15%, when comparing singles transmission measurement to current coincidence transmission measurement. The major advantage of using singles transmission measurement IS a dramatically increased count rate. A factor of seven increase in count rate over coincidence scanning is possible with a 2 mCi transmission rod source. There are no randoms counted in singles transmission scans, which makes the measured count rate nearly linearly proportional with source activity. Singles detector dead time is approximately 6% in the detectors opposite a 2 mCi rod source. Present hardware and software precludes the application of this technique in a clinical environment. We anticipate that real time acquisition of detector singles can reduce the transmission scanning time to under 2 minutes, and produce attenuation coefficient images with under 2% noise. This is a significant improvement compared to the current coincidence transmission technique.
Coronary Kinin Generation Mediates Nitric Oxide Release After Angiotensin Receptor Stimulation (1995)

Our goal was to determine whether angiotensin II (Ang II) and its metabolic fragments release nitric oxide and the mechanisms by which this occurs in blood vessels from the canine heart. We incubated 20 mg of microvessels or large coronary arteries in phosphate-buffered saline for 20 minutes and measured nitrite release. Nitrite release increased from 27 +/- 2 up to 103 +/- 5, 145 +/- 17, 84 +/- 4, 107 +/- 16, and 54 +/- 4 pmol/mg (P < .05) in response to 10(-5) mol/L of Ang I, II, III, IV, and Ang-(1-7), respectively. The effects of all angiotensins were blocked by N omega-nitro-L-arginine methyl ester (100 mumol/L), indicating that nitrite was a product of nitric oxide metabolism, and by Hoe 140 (10 mumol/L), a specific bradykinin B2 receptor antagonist, indicating a potential role for local kinin formation. The protease inhibitors aprotinin (10 mumol/L) and soybean trypsin inhibitor, which block local kinin formation, inhibited nitrite release by all of the angiotensins. Angiotensin nonselective (saralasin), type 1-specific (losartan), and type 2-specific (PD 123319) receptor antagonists abolished the nitrite released in response to all the fragments. Angiotensin type 1 and type 2 and receptors mediate nitrite release after Ang I, II, III, and Ang-(1-7), whereas only type 2 receptors mediate nitrite release after Ang IV. Similar results were obtained in large coronary arteries. In summary, formation of nitrite from coronary microvessels and large arteries in the normal dog heart in response to angiotensin peptides is due to the activation of local kinin production in the coronary vessel wall.
Agglomeration and electrical percolation behavior of carbon black dispersed in epoxy resin (1997)

In conductive polymer compounds, the filler volume fraction at which a network of touching particles is formed is not a constant but depends on the manufacturing process. By applying three main features—particle-particle interaction, dynamics of agglomeration, and structure of agglomerates—which are well known in colloid science to filled polymers, the electrical percolation behavior can be understood. Thus, it is possible to explain the hitherto found low percolation thresholds of less than 0.5 vol% in carbon-black-filled resins and, hence, further reduce the threshold to 0.06 vol%. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 63: 1741–1746, 1997
Destruction of sulfonol in its aqueous solutions by contact glow discharge treatment: 2. Mechanisms and kinetic simulation (2013)

A mechanism for the degradation of Sulfonol in its aqueous solutions acting as a liquid cathode of atmospheric-pressure dc discharge in air and for the formation of the products has been proposed, and the chemical kinetics of the degradation processes has been numerically simulated.
Ten Challenges in the Management of Neuroblastoma (2012)

Neuroblastoma is a complex disease with many contradictions and challenges. It is, by and large, a cancer of babies and preschool children, but it does occur, albeit increasingly rarely, in older children, adolescents and young adults. The prognosis is very variable, with outcome related to age, stage and molecular pathology. Neuroblastoma may behave in an almost benign way, with spontaneous regression in some infants, but the majority of older patients have high-risk disease, which is usually fatal, despite best current treatments. As a rare disease, international collaboration is essential to run clinical trials of adequate statistical power to answer important questions in a reasonable time frame. High-risk disease requires multimodality therapy including chemotherapy, surgery and radiotherapy as well as biological and immunological treatments for optimal outcomes. Innovative treatment approaches, sometimes associated with appreciable toxicity, offer hope for the future but, despite parental wishes, cannot be generally implemented without adequate assessment in clinical trials.
A novel approach to investigating the erythroid lineage, using both receptor analysis and haemoglobin detection (1996)

Progenitor cell failure in the erythroid lineage is a particular problem in bone marrow failure. To provide insight into early erythopoietic development we used sensitive techniques to examine the effects of SCF, IL-3 and MIP-1 alpha on two developmentally arrested progenitor cell lines, HEL and K562. Quantitative flowcytometric analysis showed that both expressed receptors (SCF > MIP-1 alpha > IL-3). Qualitative analysis revealed HEL cells expressed more receptors than K562 cells. Clonogenic assays with sensitive haemoglobin detection showed that SCF and IL-3 did not support HEL development and reduced haemoglobin production. MIP-1 alpha reduced partially developed HEL colonies and haemoglobin in developed colonies. SCF increased development, but not haemoglobin in K562 cells, with IL-3 being more effective in both. MIP-1 alpha increased the proportion of well-developed K562 colonies but not haemoglobin. This suggests SCF, IL-3 and MIP-1 alpha all have a role to play in early erythroid cellular development, with differing actions depending on the stage of development.
Some properties of deoxycholate and dodecyl sulphate in relation to macroionic complexes and their biochemical implications. (1978)

The present communication describes new properties and re-explores some poorly understood characteristics of deoxycholate (DOC, bile salts) and dodecyl sulphate (SDS). These anionic detergents form complexes with basic compounds including drugs and biologically important compounds; the excess of the reagents generally dissolves a complex. A variety of two-component macroionic complexes involving oppositely charged compounds are also dissolved by these reagents. This process implies the dissociation of a complex into its constituent components by DOC/SDS. This would suggest a new attribute of the anionic detergents of breaking up ionic linkages involved in macroionic complexes. This technique makes it possible to obtain quantitative information on the behaviour of binary macroionic complexes. The newly explored characteristics of bile salts might even operate in vivo and thereby explain some of their harmful effects in disorders associated with their elevated levels in vivo. An interference with the action of drugs by bile salts could be another side effect of the latter in the relevant pathological conditions.