gebhart/patrepeval huggingface dataset:
Rapid on-chip recalcification and drug dosing of citrated whole blood using microfluidic buffer sheath flow (2014)

Millions of clotting tests each year require recalcification of blood treated with sodium citrate, a calcium chelator that prevents prothrombinase assembly. We validated a converging trifurcated microfluidic device to measure platelet and fibrin accumulation following on-chip recalcification of citrated whole blood. Recalcification was accomplished by sheathing the blood with Ca2+ buffer. Fluorescein rapidly diffused across the buffer-blood interface (achieving 62.5% of maximum centerline concentration within ~4 cm of flow), while albumin remained relatively unchanged in blood due to its lower diffusivity (<20% decrease). Since Ca2+ diffuses faster than fluorescein, full recalcification of whole blood was achieved within ~1 cm of flow prior to encountering a collagen/tissue surface. Platelet and fibrin were reduced by 87.3% and 99.0%, respectively, when the sheath buffer was Ca2+-free. A 30-min preincubation of citrated whole blood prior to on-chip recalcification increased platelet (159%) and fibrin (86.6%) deposition, compared to 5-min preincubation, likely due to factor XIIa generation in citrated blood. The P2Y1 inhibitor, MRS-2179, was delivered by diffusion into flowing blood and inhibited platelet deposition on collagen with a calculated IC50 of 0.155 μM. On-chip recalcification and drug dosing of citrated blood allows for assays of platelet function in a whole blood milieu under flow.
The haemodynamic effects of intravenous nifedipine in normotensive and hypertensive subjects. (1988)

The antihypertensive effects of intravenous nifedipine, given by bolus and 2 hour infusion, were studied at two dose levels in seven hypertensive (mean BP 178/114 mmHg) and five age-matched normotensive controls (mean BP 128/81 mmHg). Nifedipine significantly reduced systolic and diastolic blood pressure in the hypertensive patients by approximately 20%, but not in the normotensive controls. Similar changes in heart rate and forearm blood flow were seen after bolus injection in both groups, but these were not sustained during infusion. Intravenous nifedipine may be a useful acute treatment for hypertensive emergencies.
Investigating Several Wireless Technologies to Build a Heteregeneous Network for the In-Flight Entertainment System inside an Aircraft Cabin (2010)

A primary difficulty when investigating communication requirements in an aircraft cabin is the diverse needs of passengers when compared to the strict constraints inside the cabin. It is recognized that there is an increasing need of passengers to use their electronic devices as well as the need for entertaining during the flight. This paper aims at integrating heterogeneous available communication technologies, showing their pros and cons -within this context while considering the imposed communication restrictions inside the aircraft's cabin.
Mutational Analysis Demonstrates That ClC-4 and ClC-5 Directly Mediate Plasma Membrane Currents (1999)

ClC-4 and ClC-5, together with ClC-3, form a distinct branch of the CLC chloride channel family. Although ClC-5 was shown to be mainly expressed in endocytotic vesicles, expression of ClC-5 in Xenopus oocytes elicited chloride currents. We now show that ClC-4 also gives rise to strongly outwardly rectifying anion currents when expressed in oocytes. They closely resemble ClC-5 currents with which they share a NO3- > Cl- > Br- > I- conductance sequence that differs from that reported for the highly homologous ClC-3. Both ClC-4 and ClC-5 currents are reduced by lowering extracellular pH. We could measure similar currents after expressing either channel in HEK293 cells. To demonstrate that these currents are directly mediated by the channel proteins, we introduced several point mutations that change channel characteristics. In ClC-5, several point mutations alter the kinetics of activation but leave macroscopic rectification and ion selectivity unchanged. A mutation (N565K) equivalent to a mutation reported to have profound effects on ClC-3 does not have similar effects on ClC-5. Moreover, a mutation at the end of D2 (S168T in ClC-5) changes ion selectivity, and a mutation at the end of D3 (E211A in ClC-5 and E224A in ClC-4) changes voltage dependence and ion selectivity. This shows that ClC-4 and ClC-5 can directly mediate plasma membrane currents.
Water transfer coefficient in adsorptive porous body. (1983)

Water transport in wet porous materials is expressed as the simultaneous transport of adsorbed water, capillary water and water vapor. The sum of the surface flow coefficient and the liquid water transfer coefficient is defined as the water transfer coefficient in this paper. The water transfer coefficient was measured by a modified method which is a kind of constant-volume method for adsorption equilibrium. An activated alumina whose pores are fine was used as the experimental material. Based on the water transfer model previously proposed by the authors, the observed dependence of the water transfer coefficient on water content and temperature were successfully interpreted.
Zeolites treated with silicon tetrachloride vapour. Part 2.—Sorption studies (1986)

Adsorption isotherms for nitrogen, water, n-butane, isobutane, benzene and cyclohexane have been measured on a series of samples of zeolite Y dealuminated with silicon tetrachloride vapour at various temperatures. Differential heats of adsorption, differential entropies, activity coefficients and virial coefficients have been calculated from the isotherms. The nature of the intracrystalline porosity and the status of the sorbed molecules and extra-framework aluminium have been considered in the light of the results.
Induction of Expression of Genes Coding for Sporamin and β-Amylase by Polygalacturonic Acid in Leaf-Petiole Cuttings of Sweet Potato (1992)

Sporamin and beta-amylase are two major proteins of tuberous storage root of sweet potato (Ipomoea batatas) and their accumulation can be induced concomitantly with the accumulation of starch in leaves and petioles by sucrose (K Nakamura, M Ohto, N Yoshida, K Nakamura [1991] Plant Physiol 96: 902-909). Although mechanical wounding of leaves of sweet potato only occasionally induced the expression of sporamin and beta-amylase genes, their expression could be reproducibly induced in leaf-petiole cuttings when these explants were dipped in a solution of polygalacturonic acid or chitosan at their cut edges. Polygalacturonic acid seemed to induce expression of the same genes coding for sporamin and beta-amylase that are induced by sucrose. Because polygalacturonic acid and chitosan are known to mediate the induction of wound-inducible defense reactions, these results raise an interesting possibility that beta-amylase, in addition to sporamin, may have some role in the defense reaction. Expression of sporamin and beta-amylase genes could also be induced by abscisic acid, and this induction by abscisic acid, as well as induction by polygalacturonic acid or sucrose, was repressed by gibberellic acid. By contrast, methyl jasmonate did not cause the significant induction of either sporamin or beta-amylase mRNAs. Induction of expression of sporamin and beta-amylase genes by polygalacturonic acid or sucrose was inhibited by cycloheximide, suggesting that de novo synthesis of proteins is required for both of the induction processes.
On-Line Efficiency Optimization of a Variable Frequency Induction Motor Drive (1985)

The problems associated with the implementation of an optimal efficiency controller in variable frequency induction motor drives are examined. A simple method for minimizing, on-line, the global system losses is presented. This method is based on the adaptive control of the rotor flux in a field-oriented drive system. The effectiveness of this control strategy is verified using digital simulation.
Development and applications of paper-based electrospray ionization-mass spectrometry for monitoring of sequentially generated droplets (2013)

In this work, sub-microlitre droplets were generated by gravity and electrostatic attraction using a capillary tube. The parameters affecting the sizes and frequency of the droplets were investigated. The volume of droplets could be controlled in the range from 0.7 μL to 2.4 μL and the time interval from 15 s to 60 s with appropriate parameters. Combining the droplets with on-line mass spectrometry (MS) via paper-based electrospray ionization (ESI), a steady flow of solvent was delivered by the capillary tube to the base-side of the paper, which maintained the consistent state of the electrospray. With this approach, each droplet produced a peak in the ion chromatogram. Relative standard deviations (RSDs) not higher than 9% for both the intensities and the time intervals were achieved when using rhodamine 6G and l-phenylalanine as model analytes. The present method was utilized for the monitoring of the amine-aldehyde condensation reaction of butylamine and benzaldehyde. Direct analysis and distribution of molecules in fruits were also performed, which demonstrated the potential application of this approach.
Constrained control allocation - Three-moment problem (1994)

This paper presents a method for the solution of the constrained control allocation problem for the case of three moments. The control allocation problem is to find the combination of several flight control effectors for the generation of specified body-axis moments. The number of controls is greater than the number of moments being controlled, and the ranges of the controls are constrained to certain limits. The controls are assumed to be individually linear in their effect throughout their ranges of motion and complete in the sense that they generate moments in arbitrary combinations. The best combination of controls is taken to be an apportioning of the controls that yields the greatest total moment in a specified ratio of moments without exceeding any control constraint. The method of solving the allocation problem is presented as an algorithm and is demonstrated for a problem of seven aerodynamic controls on an F-18 airplane.
Fast Intra-mode Decision Algorithm for HEVC Based on Texture Direction (2014)

To improve the coding efficiency of intra frame, a quad tree-based variable block size coding structure which is flexible to adapt to various texture characteristics of images and up to 35 intra prediction modes are adopted in the latest High Efficiency Video Coding (HEVC) standard. To further alleviate the encoder computation load, this paper proposes a fast intra mode decision algorithm based on texture direction. In the paper, the original multiple mode candidates for each prediction unit are reduced with its texture direction. The simulation results show that the proposed algorithm could reduce around 30% encoding time in average while maintaining the encoding performance efficiently with only 0.7% increase in BD-rate compared to the test model HM10.0 of HEVC.
A compact microstrip slot antenna with novel E-shaped coupling aperture (2010)

A microstrip slot antenna with novel E-shaped coupling aperture is presented. Different parameters of the antenna are explored. It's shown that by varying the dimensions of E-shaped slot and length of Ls (matching stub), the antenna can be designed for high gain, dual band or quad band characteristic. As it's shown compacting the antenna is also possible. A simple patch antenna, a dual band antenna and a practical quad band antenna is designed. The last one is developed to meet IEEE 802.11a/b/g and IEEE 802.16d standards in order to cover all of the wireless LAN and WiMAX frequency bands. Last two antennas are 47% smaller than a regular patch antenna resonating at 2.47GHz while providing relative high gain and very good efficiency. HFSS and CST softwares are exploited to verify the antennas performance.
Towards Blockchain-based Auditable Storage and Sharing of IoT Data (2017)

Today the cloud plays a central role in storing, processing, and distributing data. Despite contributing to the rapid development of IoT applications, the current IoT cloud-centric architecture has led into a myriad of isolated data silos that hinders the full potential of holistic data-driven analytics within the IoT. In this paper, we present a blockchain-based design for the IoT that brings a distributed access control and data management. We depart from the current trust model that delegates access control of our data to a centralized trusted authority and instead empower the users with data ownership. Our design is tailored for IoT data streams and enables secure data sharing. We enable a secure and resilient access control management, by utilizing the blockchain as an auditable and distributed access control layer to the storage layer. We facilitate the storage of time-series IoT data at the edge of the network via a locality-aware decentralized storage system that is managed with the blockchain technology. Our system is agnostic of the physical storage nodes and supports as well utilization of cloud storage resources as storage nodes.
Macular OCT Classification Using a Multi-Scale Convolutional Neural Network Ensemble (2017)

Computer-aided diagnosis (CAD) of retinal pathologies is a current active area in medical image analysis. Due to the increasing use of retinal optical coherence tomography (OCT) imaging technique, a CAD system in retinal OCT is essential to assist ophthalmologist in the early detection of ocular diseases and treatment monitoring. This paper presents a novel CAD system based on a multi-scale convolutional mixture of expert (MCME) ensemble model to identify normal retina, and two common types of macular pathologies, namely, dry age-related macular degeneration, and diabetic macular edema. The proposed MCME modular model is a data-driven neural structure, which employs a new cost function for discriminative and fast learning of image features by applying convolutional neural networks on multiple-scale sub-images. MCME maximizes the likelihood function of the training data set and ground truth by considering a mixture model, which tries also to model the joint interaction between individual experts by using a correlated multivariate component for each expert module instead of only modeling the marginal distributions by independent Gaussian components. Two different macular OCT data sets from Heidelberg devices were considered for the evaluation of the method, i.e., a local data set of OCT images of 148 subjects and a public data set of 45 OCT acquisitions. For comparison purpose, we performed a wide range of classification measures to compare the results with the best configurations of the MCME method. With the MCME model of four scale-dependent experts, the precision rate of 98.86%, and the area under the receiver operating characteristic curve (AUC) of 0.9985 were obtained on average.
A 1.2-V 100KS/S energy efficient supply boosted SAR ADC (2013)

This paper presents a new energy efficient supply boosted (SB) successive approximation register (SAR) type analog-to-digital converter (ADC) designed in a high-Vth CMOS process. Supply boosting technique (SBT) improves input common mode range and minimum operation voltage of mixed-signal circuits even when threshold voltages are in the order of the supply voltage. A 10-bit SB- SAR ADC was designed and fabricated in a standard 0.5 μm, 5V, 2P3M, CMOS process in which threshold voltages of NMOS and PMOS devices are +0.8V and -0.9V, respectively. Fabricated SB-SAR ADC achieves effective number of bits (ENOB) of 8.24, power consumption of 6μW from a 1.2Volt supply. Measured figure of merit (FoM) was 163fJ and 196fJ per conversion-step for sampling rates of 80KS/s and 100KS/s, respectively.
Olfactory Dysfunction in Schizophrenia: A Review of Neuroanatomy and Psychophysiological Measurements (2010)

Olfactory processing is thought to be mediated via the frontal and temporolimbic brain regions, both of which, as well as olfactory dysfunction, are implicated in schizophrenia. Likewise, several empirical studies of olfactory dysfunction--in particular, olfactory deficits in identification, odor detection threshold sensitivity, and odor memory, along with associated brain structural changes--have been conducted to illuminate the pathophysiology of schizophrenia. These anomalies have been investigated, more recently, as possible biological markers of that disabling illness. This article summarizes recent research on neuroimaging changes associated with olfactory impairments in schizophrenia patients and on related functional changes in psychophysiological measurements (e.g., odor identification, odor discrimination, odor detection threshold, and odor memory). The possible role of these changes as biological markers of the disorder will be discussed, as will potentially productive directions for future research.
Presentation et evaluation de la complexite en moyenne d'algorithmes de filtrage dans les moteurs d'inferences (algorithmes RETE et arbre d'unification) (1987)

Résumé disponible dans les fichiers attachés
Novel type of broadband travelling-wave integrated-optic modulator (1985)

We propose and analyse a novel type of baseband travelling-wave integrated-optic modulator which has a broadened baseband response compared with corresponding modulators of conventional design. Numerical calculations are reported for this novel structure, and a comparison of figures of merit for the novel modulator and conventional types is given.
A Case Report of Granular Cell Tumor of the Bronchus with a Review of Clinicopathologic Findings of 33 Cases Reported in Japan. (2000)

気管支原発の顆粒細胞腫1例と本邦33例の文献報告について臨床細胞組織学的に検討した. 症例; 39歳, 男性. 健診時の胸部X線写真上, 左上肺野に異常陰影が指摘された. 気管支鏡検査で粘膜下腫瘍による左B1+2cの閉塞所見が認められた. 擦過及び擦過後気管支洗浄細胞診検査においてシート状配列を示し, 豊富な顆粒状細胞質と小型類円形核からなる腫瘍細胞と, その細胞質内に封入体を認めたため, 顆粒細胞腫と診断した. 左上区区域切除術が施行された. 病巣部は長軸方向12mmにわたり, 白色乳頭状腫瘍であった. 組織学的には特徴的な大型好酸性顆粒状細胞質内にジアスターゼ耐性のPAS強陽性のangulate bodyが認められた. 免疫組織学的にS-100蛋白陽性で, 電顕的にはschwann cellの特徴を示していた. 術後4年間, 再発転移は認められていない. 結語; 本例は顆粒細胞腫の末梢神経細胞の起源説を支持する所見を有している.
One-dimensional array of ion chains coupled to an optical cavity (2013)

We present a novel system where an optical cavity is integrated with a microfabricated planar-electrode ion trap. The trap electrodes produce a tunable periodic potential allowing the trapping of up to 50 separate ion chains aligned with the cavity and spaced by 160 μm in a one-dimensional array along the cavity axis. Each chain can contain up to 20 individually addressable Yb+ ions coupled to the cavity mode. We demonstrate deterministic distribution of ions between the sites of the electrostatic periodic potential and control of the ion-cavity coupling. The measured strength of this coupling should allow access to the strong collective coupling regime with 10 ions. The optical cavity could serve as a quantum information bus between ions or be used to generate a strong wavelength-scale periodic optical potential. © IOP Publishing and Deutsche Physikalische Gesellschaft.
Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia (2011)

FMS-like tyrosine kinase 3 (FLT3) is the most commonly mutated gene found in acute myeloid leukemia (AML) patients and its activating mutations have been proven to be a negative prognostic marker for clinical outcome. Pacritinib (SB1518) is a tyrosine kinase inhibitor (TKI) with equipotent activity against FLT3 (IC(50)=22 n) and Janus kinase 2 (JAK2, IC(50)=23 n). Pacritinib inhibits FLT3 phosphorylation and downstream STAT, MAPK and PI3 K signaling in FLT3-internal-tandem duplication (ITD), FLT3-wt cells and primary AML blast cells. Oral administration of pacritinib in murine models of FLT3-ITD-driven AML led to significant inhibition of primary tumor growth and lung metastasis. Upregulation of JAK2 in FLT3-TKI-resistant AML cells was identified as a potential mechanism of resistance to selective FLT3 inhibition. This resistance could be overcome by the combined FLT3 and JAK2 activities of pacritinib in this cellular model. Our findings provide a rationale for the clinical evaluation of pacritinib in AML including patients resistant to FLT3-TKI therapy.
Guest Editorial (1999)

"Guest Editorial." IETE Technical Review, 16(1), pp. 3–4 Additional informationNotes on contributorsS PalS Pal (FIETE, FNAE, FNASC, SMIEEE (USA), MASTr. SI. MAMTA (USA), MSc (Physics), MSc (Tech) Electronics BIT Pilani, PhD (Communications)—IISc. Bangalore is presently Group Director. Communication Systems Group, ISRO Satellite Centre, Bangalore.After a brief tenure at TIFR (Ooty/ Bombay), Dr Pal, a space communication technologist, joined Indian Space Research Organization (ISRO) in 1971. Dr Pal is responsible for starting antenna & microwave activities at ISRO Satellite Centre from the inception. He has been responsible for the development and fabrication of all spacecraft related telecommunication systems for India's all satellites (this includes the high sensitivity S & C hand TT&C transponders high bit rate QPSK. BPSK data transmitters at S & X bands, directional, shaped and wide beam antennas and ommdirectional antennas) The technologies developed have helped ISRO to save several crores of foreign exchange. He has also developed and supplied various high technological systems for DRDO that includes the ultra low side lobe antenna array for CABS and L&C band antennas for remote piloted aircraft for ADE. He has been consultant to (1)INMARSAT/ICO(UK) for LEOSA definitions and responsible for the development of Satellite Hand Held Telephone Antenna System for ICO (UK) & (ii) ITU for defining Region African Satellite Communication System.Dr Pal has received many awards including the prestigious Hari Om Ashram Prerit Vikram Sarabhai Research Award for research electronics and telematics (1989), National Research Development Corporation (NRDC)—Independence Day Invention Awards (1994, 1995) and Republic Day Award (1997) for various innovative developments and inventions. 21st IETE-Ram Lal Wadhwa Gold Medal Award (1996–97) and Dr Biren Roy Space Science award 1998.Dr Pal has published more than 120 papers in international and national journals of repute. He has also co-authored a two volume books ‘Perspectives in Communications’. He has guided numerous ME and PhD students for their dissertations. He is on the editorial board of Journal of Scientific and Industrial Research (JSIR). Journal of Spacecraft Technology (JST) and guest editor for IETE journals. He is a keen participant in the activities of IETE, having arranged various courses, lectures and other technical activities for the institution. He is serving member of IETE Council (1998–99) and has been on the Council in the past (1994–97) He was the chairman of the IT & Computer Education Commi of the IETE in 1996–97.His fields of interest are microwaves, space communications, electromagnetics and antennas.