gebhart/patrepeval huggingface dataset:
High Levels of Hsp90 Cochaperone p23 Promote Tumor Progression and Poor Prognosis in Breast Cancer by Increasing Lymph Node Metastases and Drug Resistance (2010)

p23 is a heat shock protein 90 (Hsp90) cochaperone located in both the cytoplasm and nucleus that stabilizes unliganded steroid receptors, controls the catalytic activity of certain kinases, regulates protein-DNA dynamics, and is upregulated in several cancers. We had previously shown that p23-overexpressing MCF-7 cells (MCF-7+p23) exhibit increased invasion without affecting the estrogen-dependent proliferative response, which suggests that p23 differentially regulates genes controlling processes linked to breast tumor metastasis. To gain a comprehensive view of the effects of p23 on estrogen receptor (ER)-dependent and -independent gene expression, we profiled mRNA expression from control versus MCF-7+p23 cells in the absence and presence of estrogen. A number of p23-sensitive target genes involved in metastasis and drug resistance were identified. Most striking is that many of these genes are also misregulated in invasive breast cancers, including PMP22, ABCC3, AGR2, Sox3, TM4SF1, and p8 (NUPR1). Upregulation of the ATP-dependent transporter ABCC3 by p23 conferred resistance to the chemotherapeutic agents etoposide and doxorubicin in MCF-7+p23 cells. MCF-7+p23 cells also displayed higher levels of activated Akt and an expanded phosphoproteome relative to control cells, suggesting that elevated p23 also enhances cytoplasmic signaling pathways. For breast cancer patients, tumor stage together with high cytoplasmic p23 expression more accurately predicted disease recurrence and mortality than did stage alone. High nuclear p23 was found to be associated with high cytoplasmic p23, therefore both may promote tumor progression and poor prognosis by increasing metastatic potential and drug resistance in breast cancer patients.
Control of spin-polarized electron magnetoresistance in Ta/NiFe/Ta films by intercalation of Au (2012)

Abstract Intercalation layers of Au were formed in Ta/NiFe/Ta films to control the interface properties of the films. It was found that small amounts of Au may enhance the magnetoresistance (MR) value up to 2.63%. The intercalation at different interfaces had different effects. Intercalation of Au at the top (bottom) interface with respect to the substrate exhibits weak (strong) diffusion of Au into NiFe. At weak diffusion, a homogeneous Au layer is formed which explains the large MR effect. At strong diffusion, since Au possesses a relatively strong spin–orbit interaction, the enhanced MR effect was explained by the spin–orbit scattering of polarized electrons in the NiFe layer.
Aspiration Induced by Remifentanil (2014)

Remifentanil infusion at concentrations used in monitored anesthesia care increases the incidence of aspiration. However, the subjective swallowing difficulty induced by remifentanil is not indicative of the aspiration risk.
Estimating the number of undetected errors: Bayesian model selection (2002)

Sometimes complex software systems fail because of faults introduced in the requirements and design stages of the development process. To improve the reliability of a software, several reviewers inspect documents related to requirements and design. Some faults are detected in this process but often a few remain undetected until the software is developed. Ebrahimi (1997) developed frequentist methods to estimate the number of faults which are nor discovered. Later, Basu and Ebrahimi and Basu developed different Bayesian models. These different Bayesian models yield different estimates of the number of undetected errors. It was further found that changes in the prior parameters often result in measurable changes in the estimates of undetected errors. The authors address the issue of model selection among these different models. They advocate two model selection methods. The first method uses marginal likelihood and Bayes factor whereas the second method is based on cross-validated likelihood. These methods are illustrated in the software review data of AT&T 5 ESS switches.
The solution thermolysis of 2-, 3-, and 4-(2-hydroxy-2-arylethyl)pyridines (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe solution thermolysis of 2-, 3-, and 4-(2-hydroxy-2-arylethyl)pyridinesYoram Houminer and David L. WilliamsCite this: J. Org. Chem. 1983, 48, 15, 2622–2625Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/jo00163a046https://doi.org/10.1021/jo00163a046research-articleACS PublicationsRequest reuse permissionsArticle Views206Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. (2004)

Use of vitamin E and vitamin C supplements in combination is associated with reduced prevalence and incidence of AD. Antioxidant supplements merit further study as agents for the primary prevention of AD.
HMG‐CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis (2004)

To determine whether neurite outgrowth depends upon the mevalonate pathway, we blocked mevalonate synthesis in nerve growth factor-treated PC12 cells or primary cortical neurones with atorvastatin, a 3-hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and substituted different intermediates of the mevalonate pathway. We show that HMG-CoA reductase inhibition causes a profound reduction of neurite length, neurite loss and ultimatively cell death in undifferentiated and pre-differentiated PC12 cells and also in rat primary cortical neurones. Geranylgeranylpyrophosphate, but not farnesylpyrophosphate, squalene or cholesterol, completely compensated for the lack of mevalonate. Our data indicate that, under HMG-CoA reductase inhibition, geranylgeranylpyrophosphate rather than farnesylpyrophosphate or cholesterol is critical for neurite outgrowth and/or maintenance. Loss of neurites is an early manifestation of various neurodegenerative disorders, and dysfunction of isoprenylation might play a role in their pathogenesis.
Demonstration of a 1550-nm photon-counting receiver with &#x226A; 0.5 detected photon-per-bit sensitivity at 187.5 Mb/s (2008)

We implemented a photon-counting optical receiver using a periodically-poled lithium niobate waveguide and an emulated array of silicon Geiger-mode avalanche photodiodes. We achieved a sensitivity of < 0.5 detected photons/bit at 187.5 Mb/s.
Treatment with Neurokinin-1 Receptor Antagonist Reduces Severity of Inflammatory Bowel Disease Induced by<i>Cryptosporidium parvum</i> (2002)

Inflammatory bowel disease (IBD) is a chronic, debilitating disorder of uncertain and perhaps multiple etiologies. It is believed to be due in part to disregulation of the immune system. Neuroimmune interactions may be involved in induction or maintenance of IBD. In the present study, we examined the potential role of a neurotransmitter, substance P, in a mouse model of IBD. We found that binding sites for substance P, and more specifically, neurokinin-1 receptors, were upregulated in intestinal tissue of mice with IBD-like syndrome. Dosing of mice with LY303870, a neurokinin-1 receptor antagonist, reduced the severity of IBD, and treatment of mice with preexisting IBD allowed partial healing of lesions. We hypothesize that blocking the binding of substance P to the neurokinin-1 receptor interrupts the inflammatory cascade that triggers and maintains intestinal lesions of IBD.
Effects and safety of preventive oral iron or iron+folic acid supplementation for women during pregnancy (2009)

Universal prenatal supplementation with iron or iron+folic acid provided either daily or weekly is effective to prevent anaemia and iron deficiency at term. We found no evidence, however, of the significant reduction in substantive maternal and neonatal adverse clinical outcomes (low birthweight, delayed development, preterm birth, infection, postpartum haemorrhage). Associated side effects and particularly haemoconcentration during pregnancy may suggest the need for revising iron doses and schemes of supplementation during pregnancy and adjust preventive iron supplementation recommendations.
Determination of hemoglobin mass and blood volume with CO: evaluation and application of a method (1995)

An improved protocol was applied to the use of carboxyhemoglobin (HbCO) saturation for the estimation of body hemoglobin (Hb) mass, red blood cell volume, and blood volume and was appraised in normal volunteers. A body size-related dose of CO (50-90 ml), estimated to change HbCO saturation by 6.5%, was introduced into a low-volume (2.8 liters) closed-circuit rebreathing system and allowed to equilibrate over 10 min. Plots of venous HbCO were characterized by a plateau after 8 min, which remained stable for at least 40 min. No loss of CO from the vascular space was evident. Three estimations of Hb mass at weekly intervals in seven subjects produced a coefficient of variation of 0.8% such that, in the absence of physiological influences, changes as little as 1.5% in Hb mass are detectable. Venesection [498 +/- 16 (SE) ml] in seven subjects was associated with a measured decrease in Hb mass after 1 wk equal to the calculated loss. Blood volume was, however, largely restored by plasma expansion. The method is sensitive and precise. It can be used safely and repeatedly in normal volunteers and hospital patients.
Ligand-Based Reduction of CO<sub>2</sub> and Release of CO on Iron(II) (2012)

A synthetic cycle for the CO(2)-to-CO conversion (with subsequent release of CO) based on iron(II), a redox-active pydridinediimine ligand (PDI), and an O-atom acceptor is reported. This conversion is a passive-type ligand-based reduction, where the electrons for the CO(2) conversion are supplied by the reduced PDI ligand and the ferrous state of the iron is conserved.
A comprehensive evaluation of strip performance in multiple blood glucose monitoring systems (2015)

Accurate self-monitoring of blood glucose is a key component of effective self-management of glycemic control. Accurate self-monitoring of blood glucose results are required for optimal insulin dosing and detection of hypoglycemia. However, blood glucose monitoring systems may be susceptible to error from test strip, user, environmental and pharmacological factors. This report evaluated 5 blood glucose monitoring systems that each use Verio glucose test strips for precision, effect of hematocrit and interferences in laboratory testing, and lay user and system accuracy in clinical testing according to the guidelines in ISO15197:2013(E). Performance of OneTouch(®) VerioVue™ met or exceeded standards described in ISO15197:2013 for precision, hematocrit performance and interference testing in a laboratory setting. Performance of OneTouch(®) Verio IQ™, OneTouch(®) Verio Pro™, OneTouch(®) Verio™, OneTouch(®) VerioVue™ and Omni Pod each met or exceeded accuracy standards for user performance and system accuracy in a clinical setting set forth in ISO15197:2013(E).
Rational and Then Serendipitous Formation of Aza Analogues of Hoveyda-Type Catalysts Containing a Chelating Ester Group Leading to a Polymerization Catalyst Family (2017)

Analogues of the well-known Hoveyda–Grubbs catalyst bearing both a chelating ester function and a chelating nitrogen atom were obtained. These complexes behave differently depending on the character of the chelating amine. Complexes containing a secondary amine underwent unexpected spontaneous oxidation of the amine group, leading to the Schiff base analogues. In contrast, complexes containing a tertiary amine were prone to intramolecular cyclization in the presence of a base (Et3N). Probing the activity of such (pre)catalysts in ring-closing metathesis reactions (RCMs) revealed their dormant character and excellent thermo-switchability. In particular, complexes bearing an iminium nitrogen fragment were found to be very useful in a delayed ring-opening metathesis polymerization (ROMP) and were therefore commercialized.
[Male-to-female agonistic support for copulation in Tibetan macaques (Macaca thibetana) at Huangshan, China]. (2013)

Biological market theory predicts that animals exchange the same commodities, or interchange different ones, to their mutual benefit. Using focal and behavioral sampling methods and continuous recording techniques, we studied Tibetan macaques (Macaca thibetana) in two study groups (YA1 and YA2) at Huangshan, China to see whether adults interchanged male-to-female agonistic support for copulation. Overall, male-to-female agonistic support was significantly correlated with copulation behaviors when data from both study groups were combined. For YA1, copulations in post-agonistic support observation (PO) was greater, but not significantly so, than random observation (RO) in the breeding season, and copulation in PO was significantly greater than RO in the non-breeding season. For YA2 copulations in PO were significantly greater than RO in both breeding and non-breeding seasons. These results suggest that a male who extends post-agonistic support to a female is significantly more likely to copulate with her. Our study provides evidence for the existence of a biological market involving interchanged social behaviors. Our study also illuminates the reproductive strategies of male competition and female choice in this species.
Development of a Virus Concentration Method and Its Application to Detection of Enterovirus and Norwalk Virus from Coastal Seawater (2002)

We developed a new procedure for concentration of enteric viruses from water using a negatively charged membrane. Rinsing the membrane with 0.5 mM H(2)SO(4) (pH 3.0) in order to elute cations prior to viral elution with 1 mM NaOH (pH 10.5) promoted poliovirus recovery yields from 33 to 95% when applied to pure water and 38 to 89% when applied to natural seawater from Tokyo Bay, Japan, respectively. This method showed average recovery yields of spiked poliovirus of 62% (n = 8) from 1 liter of artificial seawater. This method showed higher recovery yields (>61%) than that of the conventional method using positively charged membrane (6%) when applied to seawater. This method is also free from beef extract elution, which has an inhibitory effect in the subsequent viral genome detection by reverse transcription-PCR. Naturally occurring Norwalk viruses from 2 liters of Tokyo Bay water in winter and infectious enteroviruses from 2 liters of recreational coastal seawater in summer were detected by using this viral concentration method.
Features: Intellectual Property and the Analytical Industry (1997)

ADVERTISEMENT RETURN TO ISSUEPREVDepartmentsNEXTFeatures: Intellectual Property and the Analytical Industry Have incidences of patent litigation increased? Celia HenryCite this: Anal. Chemi. 1997, 69, 23, 737A–739APublication Date (Web):June 1, 2011Publication History Published online1 June 2011Published inissue 1 December 1997https://pubs.acs.org/doi/10.1021/ac971838ghttps://doi.org/10.1021/ac971838gresearch-articleACS PublicationsRequest reuse permissionsArticle Views37Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Displacement vector measurement using instantaneous ultrasound signal phase-multidimensional autocorrelation and Doppler methods (2008)

Two new methods of measuring a multidimensional displacement vector using an instantaneous ultrasound signal phase are described, i.e., the multidimensional autocorrelation method (MAM) and multidimensional Doppler method (MDM). A high measurement accuracy is achieved by combining either method with the lateral Gaussian envelope cosine modulation method (LGECMM) or multidirectional synthetic aperture method (MDSAM). Measurement accuracy is evaluated using simulated noisy echo data. Both methods yield accurate measurements comparable to that of our previously developed cross-spectrum phase gradient method (MCSPGM); however, they require less computational time (the order, MDM < MAM approximate, equals MCSPGM) and would provide realtime measurements. Moreover, comparisons of LGECMM and MDSAM performed by geometrical evaluations clarifies that LGECMM has potentials to yield more accurate measurements with less computational time. Both MAM and MDM can be applied to the measurement of tissue strain, blood flow, sonar data, and other target motions.
Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor β/bone morphogenetic protein inhibitors during experimental osteoarthritis (2003)

Our results indicate a pivotal role of endogenous TGFbeta in the development of osteophytes and synovial thickening, implicating endogenous TGFbeta in the pathogenesis of OA. In contrast, the prevention of cartilage damage by endogenous TGFbeta signifies the protective role of TGFbeta in articular cartilage. This is the first study to demonstrate that endogenous BMPs are involved in osteophyte formation and synovial thickening in experimental OA.
From Molecular Biology to Targeted Therapies for Hepatocellular Carcinoma: The Future Is Now (2007)

Hepatocellular carcinoma (HCC) is characterized as a highly chemoresistant cancer with no effective systemic therapy. Despite surgical or locoregional therapies, prognosis remains poor because of high tumor recurrence or tumor progression, and currently there are no well-established effective adjuvant therapies. The molecular biology of carcinogenesis and tumor progression of HCC has been increasingly understood with intense research in recent years. Several important intracellular signaling pathways such as the Ras/Raf/Mek/Erk pathway and PI3k/Akt/mTOR pathway have been recognized, and the role of several growth factors and angiogenic factors such as EGF and VEGF has been confirmed. Effective agents targeting these molecular abnormalities have been developed and widely tested in preclinical studies of HCC cell lines or xenograft models. Several agents have entered clinical trials in HCC patients, and recent data indicated that a multikinase inhibitor targeting Ras kinase and VEGFR-2, sorafenib, is effective in prolonging survival of patients with advanced HCC. The management of advanced HCC is entering the era of molecular targeting therapy, which is of particular significance for HCC in view of the lack of existing effective systemic therapy for this cancer.
Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk. (2002)

Oxidative stress may be one mechanism by which tobacco smoke causes lung cancer. A common oxidative damage to DNA is the highly mutagenic 7,8-dihydro-8-oxoguanine adduct, which can be repaired by 8-oxoguanine glycosylase I (OGG1). A Ser326Cys substitution polymorphism in the hOGG1 gene has been suggested, based on in vitro data, to reduce the activity of the enzyme. We tested the association of this polymorphism with lung cancer in a population-based, case control study of 298 cases and 405 controls of Caucasian, Japanese, or Native Hawaiian ancestry in Hawaii. Subjects were genotyped with a PCR-RFLP assay, and odds ratios were estimated by logistic regression after adjustment for other observed risk factors, including smoking and vegetable intake. We found marked differences in the frequencies of the hOGG1 Cys variant allele among ethnic groups (45% in Hawaiians, 42% in Japanese, and 22% in Caucasians). The homozygous Cys/Cys genotype was also found to be more common in cases than controls (P = 0.008), with an odds ratio of 2.1 (95% confidence interval: 1.2-3.7) for this genotype compared with the Ser/Ser genotype. Heterozygous individuals were not at increased risk. This association with the Cys/Cys genotype was observed for each sex, ethnic group, and lung cancer cell type. There was also the suggestion that vegetable intake may not be protective against lung cancer among subjects with the Cys/Cys genotype. These data suggest that the presence of two hOGG1 326Cys alleles confers a 2-fold increased risk of lung cancer. Additional studies need to be conducted to confirm this association.
Direct and indirect electrocaloric measurements using multilayer capacitors (2010)

We report the discovery of serendipitous electrocaloric (EC) effects in commercial multilayer capacitors based on ferroelectric BaTiO 3 . Direct thermometry records ∼0.5 K changes due to 300 kV cm −1 , over a wide range of temperatures near and above room temperature. Similar results are obtained indirectly, via thermodynamic analysis of ferroelectric hysteresis loops. We compare and contrast these two results. Optimized EC multilayer capacitors could find applications in future cooling technologies.
Immunotherapy of Cancer (Review) (2016)

We present a review of modern methods of immunotherapy of cancer. The following main types of immunotherapy are considered: active and passive, specific and non-specific. Active non-specific immunotherapy of tumors is based on the use of cytokines, some bacterial products, synthetic molecules and hormones; active specific immunotherapy -on the use of vaccines on tumor-associated or viral antigens. The main approaches of passive non-specific immunotherapy are adoptive T cell therapy as well as the use of heat-shock proteins and lectins. Passive specific immunotherapy is based on the injection of monoclonal antibodies. Special attention is paid in the review to the mechanisms of the antitumor effects of immunotherapeutic agents: their effects on the cells of the immune system as well as their inhibition of tumor progression. The results of some in vitro and in vivo preclinical studies and of the clinical trials of different medications are presented. The prospects for the use of immunotherapy in the treatment of cancer are discussed.