gebhart/patrepeval huggingface dataset:
Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases (2014)

Recently, it has been shown that in patients with AD (Alzheimer's disease) and, to some degree, in patients with PD (Parkinson's disease) insulin signalling is impaired. This finding has initiated a range of research projects that showed remarkable improvements using treatments that initially had been developed to treat diabetes. Pre-clinical studies showed good neuroprotective effects when applying insulin or long-lasting analogues of incretin peptides. In transgenic animal models of AD and PD, analogues of the incretin GLP-1 (glucagon-like peptide 1) prevented neurodegenerative processes and improved neuronal and synaptic functionality in AD and PD. Amyloid plaque load and synaptic loss as well as cognitive impairment had been ameliorated in AD models, and dopaminergic loss of transmission and motor function was reversed in models of PD. On the basis of these promising findings, several clinical trials are being conducted with the first encouraging clinical results being published. In several pilot studies in AD patients, the nasal application of insulin showed encouraging effects on cognition and biomarkers. A pilot study in PD patients testing a GLP-1 receptor agonist that is currently on the market as a treatment for Type 2 diabetes also showed encouraging effects. Several other clinical trials are currently ongoing in AD patients. The present review summarizes the range of neuroprotective effects that these drugs have demonstrated and emphasizes the great promise that this approach has in providing novel treatments that have protective and even restorative properties that no current drug treatment can offer.
A Design Method For Turbine Blades Using Genetic Algorithms On Parallel Computers (1998)

Abstract. The design of 2-D turbine blades using tar-get pressure considerations is described. It is based on the optimization of a set of free-parameters through Ge-netic Algorithms (GAs). Profile shapes are modeled using combinations of circular arcs and Bezier functions. The number of free-parameters may vary, depending on the particular design requirements; they practically consist of the radii and orientations of the circular arcs and the control-points of the Bezier functions, but other parame-ters may be optimized as well. The exploitation capabili-ties of the GA are improved using adaptive ranges for the free-parameters. Close to the optimum solution, the GA switches to an iterative hillclimbing (HC) method, which undertakes the final refinement. The method application is demonstrated in a steam-turbine blade design problem. 1
Smoking and Age-related Macular Degeneration (1998)

This study further confirms the adverse effect of tobacco on late ARMD. Former smokers seem to remain at high risk for ARMD.
Farmers’ Awareness and Use of IPM for Soybean Aphid Control: Report of Survey Results for the 2004, 2005, 2006, and 2007 Crop Years (2008)

In response to the introduction and rapid spread of soybean aphid, farmers in the Upper Midwest were surveyed about their treatment of and knowledge about soybean aphids for crop years 2004, 2005, 2006, and 2007. Overall, the farmers showed a fairly good understanding of soybean aphids and their impact on soybeans. Over 80% said soybean aphids could be treated and repopulate in the same crop year. For 2004-2006, at least 75% of the farmers said aphids damaged their soybeans by sucking sap. However this percentage dropped to 59% for 2007 with a greater percentage pointing at a combination of damage methods. This lower percentage for 2007 may be due to a broader, randomly selected sample of farmers who received the surveys by mail versus farmers who attended meetings in the first three years. However, even though fewer seemed to have a clear understanding of how aphids damage soybeans, other measures indicate a stable or improved understanding of soybean aphid biology and control. Over 70% said the frequency with which aphids should be treated for profitable control depends on aphid counts, weather conditions and plant growth stage. About a third of the farmers believed that aphids inflict the most damage during early flowering through pod set (R1-R3); however, about a third also thought aphids could inflict the most damage at any stage. Over half the farmers considered the lowest aphid density for profitable aphid control to be 250 aphids per plant. Over 80% said scouting reports were very important for making a decision to treat for aphids; over half the farmers said plant growth stage was also very important.
Subwavelength Direct Laser Patterning of Conductive Gold Nanostructures by Simultaneous Photopolymerization and Photoreduction (2011)

This article presents a new method for fabricating highly conductive gold nanostructures within a polymeric matrix with subwavelength resolution. The nanostructures are directly written in a gold precursor-doped photoresist using a femtosecond pulsed laser. The laser energy is absorbed by a two-photon dye, which induces simultaneous reduction of gold in the precursor and polymerization of the negative photoresist. This results in gold nanoparticle-doped polymeric lines that exhibit both plasmonic effects, due to the constituent gold nanoparticles, and relatively high conductivity (within an order of magnitude of the bulk metal), due to the high density of particles within these lines. Line widths from 150 to 1000 nm have been achieved with this method. Various optically functional structures have been prepared, and their structural and optical properties have been characterized. The influence of laser intensity and scan speed on feature size have been studied and found to be in agreement with predictions of a mathematical model of the process.
Synthesis and Polymerization of Bicyclic Ketals: A Practical Route to High-Molecular Weight Polyketals (2013)

Polyketals are an important class of materials for drug delivery to sensitive tissues as they degrade in vivo to nonacidic species. We report the synthesis of high-molecular weight cyclic polyketals by the cationic ring-opening polymerization of bicyclic ketal monomers, which were prepared by the metal-catalyzed rearrangement of epoxy ketones. Three different cyclic polyketals with high molecular weights were synthesized using this protocol.
Efficient Highly-Parallel Decoder Architecture for Quasi-Cyclic Low-Density Parity-Check Codes (2007)

In this paper, the authors propose an efficient highly-parallel decoder architecture using partially overlapped decoding scheme for quasi-cyclic (QC) low-density parity-check (LDPC) codes, which leads to reduction in hardware complexity and power consumption. Generally, due to the regularly structured parity-check matrix H of QC LDPC codes, the message updating computations in the check node unit (CNU) and the variable node unit (VNU) can be efficiently overlapped, which increases the decoding throughput by maximizing the hardware utilization efficiency (HUE). However, the partially overlapped decoding scheme cannot be used to design a highly-parallel decoding architecture for high-throughput applications. For (3, 5)-regular QC LDPC codes, our proposed method could reduce the hardware complexity by approximately 33% for the CNU and 20% for the VNU in the highly-parallel decoder architecture without any performance degradation. In addition, the power consumption can be minimized by reducing the total number of memory accesses for updated messages.
Unmanned Aerial Vehicles (UAVs) and Artificial Intelligence Revolutionizing Wildlife Monitoring and Conservation (2016)

Surveying threatened and invasive species to obtain accurate population estimates is an important but challenging task that requires a considerable investment in time and resources. Estimates using existing ground-based monitoring techniques, such as camera traps and surveys performed on foot, are known to be resource intensive, potentially inaccurate and imprecise, and difficult to validate. Recent developments in unmanned aerial vehicles (UAV), artificial intelligence and miniaturized thermal imaging systems represent a new opportunity for wildlife experts to inexpensively survey relatively large areas. The system presented in this paper includes thermal image acquisition as well as a video processing pipeline to perform object detection, classification and tracking of wildlife in forest or open areas. The system is tested on thermal video data from ground based and test flight footage, and is found to be able to detect all the target wildlife located in the surveyed area. The system is flexible in that the user can readily define the types of objects to classify and the object characteristics that should be considered during classification.
α-Synuclein accumulates in huntingtin inclusions but forms independent filaments and its deficiency attenuates early phenotype in a mouse model of Huntington's disease (2011)

Huntington's disease (HD) is the most common of nine inherited neurological disorders caused by expanded polyglutamine (polyQ) sequences which confer propensity to self-aggregate and toxicity to their corresponding mutant proteins. It has been postulated that polyQ expression compromises the folding capacity of the cell which might affect other misfolding-prone proteins. α-Synuclein (α-syn) is a small neural-specific protein with propensity to self-aggregate that forms Parkinson's disease (PD) Lewy bodies. Point mutations in α-syn that favor self-aggregation or α-syn gene duplications lead to familial PD, thus indicating that increased α-syn aggregation or levels are sufficient to induce neurodegeneration. Since polyQ inclusions in HD and other polyQ disorders are immunopositive for α-syn, we speculated that α-syn might be recruited as an additional mediator of polyQ toxicity. Here, we confirm in HD postmortem brains and in the R6/1 mouse model of HD the accumulation of α-syn in polyQ inclusions. By isolating the characteristic filaments formed by aggregation-prone proteins, we found that N-terminal mutant huntingtin (N-mutHtt) and α-syn form independent filamentous microaggregates in R6/1 mouse brain as well as in the inducible HD94 mouse model and that N-mutHtt expression increases the load of α-syn filaments. Accordingly, α-syn knockout results in a diminished number of N-mutHtt inclusions in transfected neurons and also in vivo in the brain of HD mice. Finally, α-syn knockout attenuates body weight loss and early motor phenotype of HD mice. This study therefore demonstrates that α-syn is a modifier of polyQ toxicity in vivo and raises the possibility that potential PD-related therapies aimed to counteract α-syn toxicity might help to slow HD.
Physical activity recognition from acceleration data under semi-naturalistic conditions (2003)

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003.
Layered-Division Multiplexing: An Enabling Technology for Multicast/Broadcast Service Delivery in 5G (2018)

Future 5G systems will include a point-to-multipoint (P2MP) transmission mode to achieve high capacity and high spectrum efficiency for multiple use cases, such as IoT, lifeline communications, and broadcast-type services. Layered-division-multiplexing (LDM) is a novel non-orthogonal multiplexing technology recently adopted by the next generation digital TV broadcast system, ATSC 3.0, which is capable of providing significant capacity improvement when delivering multiple broadcast services simultaneously. This article explores the application of LDM as an enabling technology for 5G to achieve high-efficiency P2MP transmission and to deliver more diversified broadcast-type services using the mobile broadband infrastructure. The potential advantages that can be offered by LDM are demonstrated by capacity analysis and computer simulations. Coverage studies show that a 5G P2MP subsystem with LDM can deliver high-quality broadcast services using the broadband infrastructure. Finally, some general guidelines on the receiver implementation are presented to minimize the hardware complexity of consumer devices.
Drinking water disinfection byproducts: review and approach to toxicity evaluation. (1999)

There is widespread potential for human exposure to disinfection byproducts (DBPs) in drinking water because everyone drinks, bathes, cooks, and cleans with water. The need for clean and safe water led the U.S. Congress to pass the Safe Drinking Water Act more than 20 years ago in 1974. In 1976, chloroform, a trihalomethane (THM) and a principal DBP, was shown to be carcinogenic in rodents. This prompted the U.S. Environmental Protection Agency (U.S. EPA) in 1979 to develop a drinking water rule that would provide guidance on the levels of THMs allowed in drinking water. Further concern was raised by epidemiology studies suggesting a weak association between the consumption of chlorinated drinking water and the occurrence of bladder, colon, and rectal cancer. In 1992 the U.S. EPA initiated a negotiated rulemaking to evaluate the need for additional controls for microbial pathogens and DBPs. The goal was to develop an approach that would reduce the level of exposure from disinfectants and DBPs without undermining the control of microbial pathogens. The product of these deliberations was a proposed stage 1 DBP rule. It was agreed that additional information was necessary on how to optimize the use of disinfectants while maintaining control of pathogens before further controls to reduce exposure beyond stage 1 were warranted. In response to this need, the U.S. EPA developed a 5-year research plan to support the development of the longer term rules to control microbial pathogens and DBPs. A considerable body of toxicologic data has been developed on DBPs that occur in the drinking water, but the main emphasis has been on THMs. Given the complexity of the problem and the need for additional data to support the drinking water DBP rules, the U.S. EPA, the National Institute of Environmental Health Sciences, and the U.S. Army are working together to develop a comprehensive biologic and mechanistic DBP database. Selected DBPs will be tested using 2-year toxicity and carcinogenicity studies in standard rodent models; transgenic mouse models and small fish models; in vitro mechanistic and toxicokinetic studies; and reproductive, immunotoxicity, and developmental studies. The goal is to create a toxicity database that reflects a wide range of DBPs resulting from different disinfection practices. This paper describes the approach developed by these agencies to provide the information needed to make scientifically based regulatory decisions.
Hydrogen Storage and Delivery: The Carbon Dioxide – Formic Acid Couple (2011)

Carbon dioxide and the carbonates, the available natural C1 sources, can be easily hydrogenated into formic acid and formates in water; the rate of this reduction strongly depends on the pH of the solution. This reaction is catalysed by ruthenium(II) pre-catalyst complexes with a large variety of water-soluble phosphine ligands; high conversions and turnover numbers have been realised. Although ruthenium(II) is predominant in these reactions, the iron(II) - tris[(2-diphenylphosphino)-ethyl]phosphine (PP3) complex is also active, showing a new perspective to use abundant and inexpensive iron-based compounds in the CO2 reduction. In the catalytic hydrogenation cycles the in situ formed metal hydride complexes play a key role, their structures with several other intermediates have been proven by multinuclear NMR spectroscopy. In the other hand safe and convenient hydrogen storage and supply is the fundamental question for the further development of the hydrogen economy; and carbon dioxide has been recognised to be a viable H2 vector. Formic acid--containing 4.4 weight % of H2, that is 53 g hydrogen per litre--is suitable for H2 storage; we have shown that in aqueous solutions it can be selectively decomposed into CO-free (CO < 10 ppm) CO2 and H2. The reaction takes place under mild experimental conditions and it is able to generate high pressure H2 (up to 600 bar). The cleavage of HCOOH is catalysed by several hydrophilic Ru(II) phosphine complexes (meta-trisulfonated triphenylphosphine, mTPPTS, being the most efficient one), either in homogeneous systems or as immobilised catalysts. We have also shown that the iron(II)--hydrido tris[(2-diphenylphosphino)ethyl]phosphine complex catalyses with an exceptionally high rate and efficiency (turnover frequency, TOF = 9425 h(-1)mol(-1); turnover number, TON = 92400) the formic acid cleavage, in environmentally friendly propylene carbonate solution, opening the way to use cheap, non-noble metal based catalysts for this reaction, too.
Binary Gabor pattern: An efficient and robust descriptor for texture classification (2012)

In this paper, we present a simple yet efficient and effective multi-resolution approach to gray-scale and rotation invariant texture classification. Given a texture image, we at first convolve it with J Gabor filters sharing the same parameters except the parameter of orientation. Then by binarizing the obtained responses, we can get J bits at each location. Then, each location can be assigned a unique integer, namely “rotation invariant binary Gabor pattern (BGP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ri</sub> )”, formed from J bits associated with it using some rule. The classification is based on the image's histogram of its BGP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ri</sub> s at multiple scales. Using BGP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ri</sub> , there is no need for a pre-training step to learn a texton dictionary, as required in methods based on clustering such as MR8. Extensive experiments conducted on the CUReT database demonstrate the overall superiority of BGP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ri</sub> over the other state-of-the-art texture representation methods evaluated. The Matlab source codes are publicly available at http://sse.tongji.edu.cn/linzhang/IQA/BGP/BGP.htm.
Transition Metal Catalysts. I. Ethylene Polymerization with a Soluble Catalyst Formed from an Aluminum Halide, Tetraphenyltin and a Vanadium Halide<sup>1</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransition Metal Catalysts. I. Ethylene Polymerization with a Soluble Catalyst Formed from an Aluminum Halide, Tetraphenyltin and a Vanadium Halide1Wayne L. Carrick, Rudolph W. Kluiber, Eugene F. Bonner, Lloyd H. Wartman, Frank M. Rugg, and Joseph J. SmithCite this: J. Am. Chem. Soc. 1960, 82, 15, 3883–3887Publication Date (Print):August 1, 1960Publication History Published online1 May 2002Published inissue 1 August 1960https://pubs.acs.org/doi/10.1021/ja01500a025https://doi.org/10.1021/ja01500a025research-articleACS PublicationsRequest reuse permissionsArticle Views363Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A New Approach to a Lyme Disease Vaccine (2011)

A single recombinant outer surface protein A (OspA) antigen designed to contain protective elements from 2 different OspA serotypes (1 and 2) is able to induce antibody responses that protect mice against infection with either Borrelia burgdorferi sensu stricto (OspA serotype-1) or Borrelia afzelii (OspA serotype-2). Protection against infection with B burgdorferi ss strain ZS7 was demonstrated in a needle-challenge model. Protection against B. afzelii species was shown in a tick-challenge model using feral ticks. In both models, as little as .03 μg of antigen, when administered in a 2-dose immunization schedule with aluminum hydroxide as adjuvant, was sufficient to provide complete protection against the species targeted. This proof of principle study proves that knowledge of protective epitopes can be used for the rational design of effective, genetically modified vaccines requiring fewer OspA antigens and suggests that this approach may facilitate the development of an OspA vaccine for global use.
Intragastric acidification inhibits motilin‐induced phase III activity in humans (2006)

In a randomized, placebo-controlled crossover design we studied the effect of gastric acidification on motilin-induced interdigestive antropyloroduodenal motility. Ten healthy volunteers participated in the study consisting of four experiments. Each experiment started after a spontaneous occurring phase III and consisted of intragastric infusion of either saline or acid (0.08 mol L(-1) HCl) for 90 min and intravenous infusion of either saline or motilin (4 pmol kg(-1) min(-1)) for 30 min. Antropyloroduodenal motility and pH were recorded continuously for 240 min. Reoccurrence of phase III was significantly (P < 0.05) earlier during intragastric saline-intravenous motilin infusion compared with control (intragastric saline-intravenous saline), 52 min (range 25-79) and 113 min (84-141) respectively. This effect was completely abolished during intragastric acid-intravenous motilin infusion, 112 min (82-142). The percentage of phase III of antral origin was significantly (P < 0.05) higher during intragastric saline-intravenous motilin infusion (90%) compared with control (30%). The mean area under the contraction (AUC) for phase II was significantly (P < 0.05) lower during intragastric saline-intravenous motilin infusion and intragastric acid-intravenous saline infusion compared with control. It is concluded that in humans intragastric acidification inhibits the effect of motilin on antroduodenal motility, decreases the AUC of antral phase II contractions and delays the occurrence of phase III of the migrating motor complex.