gebhart/patrepeval huggingface dataset:
Meta-Analysis of the Luminal and Basal Subtypes of Bladder Cancer and the Identification of Signature Immunohistochemical Markers for Clinical Use (2016)

U.S. National Cancer Institute and National Institute of Health.
Identification of a Crucial Site for Synoviolin Expression (2005)

Synoviolin is an E3 ubiquitin ligase localized in the endoplasmic reticulum (ER) and serving as ER-associated degradation system. Analysis of transgenic mice suggested that synoviolin gene dosage is implicated in the pathogenesis of arthropathy. Complete deficiency of synoviolin is fatal embryonically. Thus, alternation of Synoviolin could cause breakdown of ER homeostasis and consequently lead to disturbance of cellular homeostasis. Hence, the expression level of Synoviolin appears to be important for its biological role in cellular homeostasis under physiological and pathological conditions. To examine the control of protein level, we performed promoter analysis to determine transcriptional regulation. Here we characterize the role of synoviolin transcription in cellular homeostasis. The Ets binding site (EBS), termed EBS-1, from position -76 to -69 of the proximal promoter, is responsible for synoviolin expression in vivo and in vitro. Interestingly, transfer of EBS-1 decoy into NIH 3T3 cells conferred not only the repression of synoviolin gene expression but also a decrease in cell number. Fluorescence-activated cell sorter analysis using annexin V staining confirmed the induction of apoptosis by EBS-1 decoy and demonstrated recovery of apoptosis by overexpression of Synoviolin. Our results suggest that transcriptional regulation of synoviolin via EBS-1 plays an important role in cellular homeostasis. Our study provides novel insight into the transcriptional regulation for cellular homeostasis.
SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish (1998)

SCL/Tal-1 is a transcription factor necessary for hematopoietic stem cell differentiation. Although SCL is also expressed in endothelial and neural progenitors, SCL function in these cells remains unknown. In the zebrafish mutant cloche (clo), SCL expression is nearly abolished in hematopoietic and vascular tissues. Correspondingly, it was shown previously that clo fails to differentiate blood and angioblasts. Genetic analysis demonstrates that the clo mutation is not linked to the SCL locus. Forced expression of SCL in clo embryos rescues the blood and vascular defects, suggesting that SCL acts downstream of clo to specify hematopoietic and vascular differentiation.
An Alternative Method of Installing ESP's (1993)

ABSTRACT Electric Submersible pumps (ESP's) traditionally have been installed on threaded pipe using workover rigs. More recently, however, three alternative methods for deploying ESP's have been presented. Two of these utilize a cable system and have been successfully demonstrated in the field. The third, overlooked until now, uses coiled tubing. Coiled tubing technology has continued to provide state-of-the art diversification in many areas of well-servicing technology, and the use of coiled tubing for ESP installations is a logical extension of these enhancements. This paper contrasts coiled tubing ESP installation methods with cable-deployed methods.
Automatic Sensor-Fault Detection System for Comprehensive Structural Health Monitoring System (2005)

Structural health monitoring systems are viewed as viable means to reduce life-cycle costs, increase structural reliability, and extend the operational hours for a wide variety of composite structures found in numerous air platforms ranging from rotorcraft to unmanned air vehicles. The system enables the constant monitoring of structural integrity and hence provides users with an assessment tool for determining the location and extent of damage, which will eventually develop and grow over time as a result of improper use or normal day-to-day operation. Errors as a result of sensor damage and/or failure could lead to erroneous readings by a built-in diagnostic system such as Acellent's SMART System, which makes use of a network of piezoelectric elements to detect damage in the structure. One of the major challenges of having a reliable structural monitoring system is to distinguish false alarms by sensors that had sustained damage during service from actual working sensors. Typical sensor damage includes sensor breakage, crushing of the sensors, and sensor debond from the host structure. This paper will discuss preliminary work that had been undertaken to increase the reliability of the SMART System by incorporating a simple circuitry for the purpose of automatic sensor fault isolation.
Resonant optical transmission through hole‐arrays in metal films: physics and applications (2009)

Abstract Extraordinary optical transmission through an array of holes in a metal film was reported by Ebbesen and coworkers in 1998. Since that work there has been abundant research activity aimed at understanding the physics and at the development of the many applications associated with this phenomenon, hence the topic of this review. The study of hole‐arrays in a metal is not new – theoretical contributions on a small‐hole array date back to Lord Rayleigh's description of Wood's anomaly in 1907 and there has been considerable research on metal meshes and hole‐arrays since 1962. Bethe's theory, adapted to treat hole‐arrays, is the simplest theoretical description of the transmission resonance. Following a description of this basic theory, we present the research on the additional effects from variations in real metal properties at different wavelengths, film thickness, hole‐shape and lattice configuration. The many promising applications being developed using hole‐arrays are examined, including polarization control, filtering, switching, nonlinear optics, surface plasmon resonance sensing, surface‐enhanced fluorescence, surface‐enhanced Raman scattering, absorption spectroscopy, and quantum interactions. Finally, the various approaches, developments in hole‐array fabrication, and integration of hole‐arrays into devices are described.
Increased Susceptibility to <i>Pseudomonas syringae</i> pv. <i>syringae</i> and <i>Pseudomonas viridiflava</i> of Kiwi Plants having Transgenic <i>rolABC</i> genes and its Inheritance in the T1 Offspring (2001)

The staminate kiwi ( Actinidia deliciosa A. Chev) cv. GTH (Late Yellow Hayward) showed high resistance to the pathogens Pseudomonas syringae pv. syringae and Pseudomonas viridiflava , contrary to the pistillate cv. Hayward which was highly susceptible to both bacteria. The resistant staminate GTH acquired susceptibility when transformed with rolABC of Agrobacterium rhizogenes . This susceptibility was inherited by the T1 offspring containing rolABC genes, derived by crossing pollen of transgenic rolABC GTH with the pistillate cv. Hayward. The susceptibility was probably correlated to high nitrogen content in the leaves of the rolABC plants. The higher susceptibility to P. s . pv. syringae than to P. viridiflava could be correlated with the high degree of auxin production by first bacterium. The high resistance to both bacteria of the staminate GTH was inherited by all the offspring lacking rolABC genes. The possibility of reducing susceptibility of rolABC plants to the pathogens by applying fewer fertilizers in the orchards, which would reduce both costs and environmental impact, is discussed.
Design and fabrication of silicon condenser microphone using corrugated diaphragm technique (1996)

A novel silicon condenser microphone with a corrugated diaphragm has been proposed, designed, fabricated and tested. The microphone is fabricated on a single wafer by use of silicon anisotropic etching and sacrificial layer etching techniques, so that no bonding techniques are required. The introduction of corrugations has greatly increased the mechanical sensitivities of the microphone diaphragms due to the reduction of the initial stress in the thin films, For the purpose of further decreasing the thin film stress, composite diaphragms consisting of multilayer (polySi/Si/sub x/N/sub y//polySi) materials have been fabricated, reducing the initial stress to a much lower level of about 70 MPa in tension. Three types of corrugation placements and several corrugation depths in a diaphragm area of 1 mm/sup 2/ have been designed and fabricated. Microphones with flat frequency response between 100 Hz and 8/spl sim/16 kHz and open-circuit sensitivities as high as 8.1/spl sim/14.2 mV/Pa under the bias voltages of 10/spl sim/25 V have been fabricated in a reproducible way. The experimental results proved that the corrugation technique is promising for silicon condenser microphone.
Study of 99mTc-TRODAT-1 imaging on human brain with children autism by single photon emission computed tomography (2005)

To evaluate the application values of<sup>99m</sup>Tc-2 β [N, N′ , - bis (2-mercaptoethy1) ethylenediamino] methyl, 3 β -(4-chlorophenyl) tropane (TRODAT-1) dopamine transporter (DAT) SPECT imaging in children autism, and offer the academic foundation to etiology, mechanism and clinical therapy of autism. Ten autistic children and ten healthy controls were examined with 99mTc-TRODAT-1 DAT SPECT imaging. Striatal specific uptake of 99mTc-TRODAT-1 was calculated with region of interest analysis according to the ratios between striatum and cerebellum [(STR-BKG)/BKG]. There was no difference in semiquantitative dopamine transporter between bilateral striatum in autistic children (p=0.562) and in normal controls (p=0.573); Dopamine transporter in brain of patients with autism increased significantly than that in normal controls (p=0.017). Dopaminergic nervous system is dysfunction in human brain with children autism, and DAT 99mTc-TRODAT-1 SPECT imaging on human brain will help the imaging diagnosis of children autism.
A double-blind trial of metronidazole versus oxytetracycline therapy for rosacea (1980)

Forty patients with papulo-pustular rosacea were treated for 12 weeks on a random double-blind basis either with oxytetracycline 250 mg twice daily or with metronidazole 200 mg twice daily. Both drugs produced an improvement which was greater after 12 weeks than after 6 weeks, but there was no significant difference between them. Metronidazole appears to be a safe and effective drug for the treatment of rosacea.
An Auditing Framework for Vulnerability Analysis of IoT System (2019)

Introduction of IoT is a big step towards the convergence of physical and virtual world as everyday objects are connected to the internet nowadays. But due to its diversity and resource constraint nature, the security of these devices in the real world has become a major challenge. Although a number of security frameworks have been suggested to ensure the security of IoT devices, frameworks for auditing this security are rare. We propose an open-source framework to audit the security of IoT devices covering hardware, firmware and communication vulnerabilities. Using existing open-source tools, we formulate a modular approach towards the implementation of the proposed framework. Standout features in the suggested framework are its modular design, extensibility, scalability, tools integration and primarily autonomous nature. The principal focus of the framework is to automate the process of auditing. The paper further mentions some tools that can be incorporated in different modules of the framework. Finally, we validate the feasibility of our framework by auditing an IoT device using proposed toolchain.
Emissions from Fischer-Tropsch Diesel Fuels (2001)

<div class="htmlview paragraph">Diesel fuels derived from Fischer-Tropsch processes have a number of beneficial properties, including zero sulfur, high cetane, and near-zero aromatics content. Previous researchers have shown emissions benefits for using these fuels in light and heavy-duty diesel engines. A series of experimental fuels using neat F-T material or blends of F-T material with conventional cracked stocks was tested in diesel engines and produced lower emissions when compared to current diesel fuel. These experimental fuels cover a variety of boiling point ranges, extending from light naphtha to materials that are significantly heavier than conventional diesel fuels. All of the fuels show lower NOx and particulate emissions. F-T material can be used to increase the use of marginal refinery streams as diesel blend stocks and so increase the volume of low emission diesel fuels produced in current refineries.</div>
Conceptual blending, somatic marking, and normativity: a case example from ancient Chinese (2005)

Abstract One purpose of this article is to support the universalist claims of conceptual blending theory by documenting its application to an ancient Chinese philosophical text, and also to provide illustrations of complex multiple-scope blends constructed over the course of conceptual blending by suggesting that, in many cases, the primary purpose of achieving human scale is not to help us apprehend a situation, but rather to help us to know how too feel about it. This argument is essentially an attempt to connect the insights of conceptual blending theorists with those of neuroscientists such Antonio Damasio who argues for the importance of somatic states and emotional reactions in human value-creation and decision-making.
Transport critical currents in spray pyrolyzed films of TlBa2Ca2Cu3O<i>z</i> on polycrystalline zirconia substrates (1992)

Large critical currents with a relatively weak magnetic field dependence are obtained in thick films of TlBa2Ca2Cu3Oz. Transport measurements indicate Jc ≳105 A/cm2 at 77 K, zero field, and Jc≳104 at 60 K in a 2 T field applied along the c-axis. The observed behavior is attributed to a large degree of uniaxial alignment of platelike grains, and to superior intragranular flux pinning. These results are consistent with recent theories concerning the nature of vortices in highly anisotropic (layered) superconductors and ‘‘brick wall’’models of intergranular current transport.
Current Developments Using Emerging Transdermal Technologies In Physical Enhancement Methods. (2006)

Transdermal drug delivery using patches offers many advantages, but is limited primarily by the stratum corneum barrier. Amongst the various methods to overcome this barrier, physical methods are gaining in popularity and commercial devices development. Macroflux, MTS and Silex are based on microporation, involving use of microneedles that pierce thereby bypassing the stratum corneum. Intraject , Powderject and Helios are based on needleless jet injectors wherein very fine, solid particulate drug, is fired directly into the skin, using high-pressure gas. Med- Tats incorporate use of modified drug-containing tattoos, which bind to the skin, wherein the drug is absorbed. CHADD is based on use of heat, which increases skin - permeation of drugs. High-power, pulsed lasers transmit positive mechanical forces to the skin and create intercellular channels into the skin transiently. Sonophoresis involves use of ultrasound, which transiently disrupts the stratum corneum barrier. This technique offers a non-invasive transdermal extraction of interstitial fluids of sampling body fluids. Modified Liposomes include Ethosomes (containing alcohol) and Transferosomes (containing surfactants), which have enhanced skin permeability. Pulsed magnetic fields may create transient pores in cell membranes, including skin, resulting in increased permeation. Iontophoresis is based on application of electric potential for enhancing the movement of substances to and from the body. Dupel, Ionzyme, Liposite, ETrans, Phoresor and Drionic are based on iontophoresis. GlucoWatch offers non-invasive blood glucose monitoring, based on reverse iontophoresis. This review outlines recent commercial developments in physical transdermal drug delivery technology and the specific devices and applications being targeted by the pharmaceutical industry.
11.1: A reliable improved Spindt cathode design for high currents (2010)

Recent work with Spindt cathodes has shown that past unreliable behavior has not been due to poor tip uniformity and the failure of over-achieving tips as has been widely believed. Rather the failures have been due to flashover along oxide walls in the cathode cavities. A new cavity architecture has solved the problem, and enabled greatly improved performance.
Opsonophagocytosis of Fluorescent Polystyrene Beads Coupled to <i>Neisseria meningitidis</i> Serogroup A, C, Y, or W135 Polysaccharide Correlates with Serum Bactericidal Activity (2002)

We developed a polysaccharide-specific flow cytometric opsonophagocytic assay (OPA) for the simultaneous measurement of functional antibody to Neisseria meningitidis serogroups A, C, Y, and W135. OPA titers significantly correlated with serum bactericidal assay titers for all serogroups tested (mean r = 0.96; P < 0.001). OPA could be used in meningococcal vaccine evaluation.
Crowdsourcing subjective image quality evaluation (2011)

Subjective tests are generally regarded as the most reliable and definitive methods for assessing image quality. Nevertheless, laboratory studies are time consuming and expensive. Thus, researchers often choose to run informal studies or use objective quality measures, producing results which may not correlate well with human perception. In this paper we propose a cost-effective and convenient subjective quality measure called crowdMOS, obtained by having Internet workers participate in MOS (mean opinion score) subjective quality studies. Since these workers cannot be supervised, we propose methods for detecting and discarding inaccurate or malicious scores. To facilitate this process, we offer an open source set of tools for Amazon Mechanical Turk, which is an Internet marketplace for crowdsourcing. These tools completely automate the test design, score retrieval and statistical analysis, abstracting away the technical details of Mechanical Turk and ensuring a user-friendly, affordable and consistent test methodology. We demonstrate crowdMOS using data from the LIVE subjective quality image dataset, showing that it delivers accurate and repeatable results.
Hierarchical depth estimation for image synthesis in mixed reality (2003)

Mixed reality is different from the virtual reality in that users can feel immersed in a space which is composed of not only virtual but also real objects. Thus, it is essential to realize seamless integration and mutual occlusion of the virtual and real worlds. Therefore, we need depth information of the real scene to perform the synthesis. We propose the depth estimation algorithm with sharp object boundaries for mixed reality system based on hierarchical disparity estimation. Initial disparity vectors are obtained from downsampled stereo images using region-dividing disparity estimation technique. Then, background region is detected and flattened. With these initial vectors, dense disparities are estimated and regularized with shape-adaptive window in full resolution images. Finally, depth values are calculated by stereo geometry and camera parameters. As a result, virtual objects can be mixed into the image of real world by comparing the calculated depth values with the depth information of generated virtual objects. Experimental results show that occlusion between the virtual and real objects are correctly established with sharp boundaries in the synthesized images, so that user can observe the mixed scene with considerably natural sensation.
Soft Nanotechnology with Soft Nanoparticles (2005)

Abstract The last decade of research in the physical sciences has seen a dramatic increase in the study of nanoscale materials. Today, “nanoscience” has emerged as a multidisciplinary effort, wherein obtaining a fundamental understanding of the optical, electrical, magnetic, and mechanical properties of nanostructures promises to deliver the next generation of functional materials for a wide range of applications. While this range of efforts is extremely broad, much of the work has focused on “hard” materials, such as Buckyballs, carbon nanotubes, metals, semiconductors, and organic or inorganic dielectrics. Meanwhile, the soft materials of current interest typically include conducting or emissive polymers for “plastic electronics” applications. Despite the continued interest in these established areas of nanoscience, new classes of soft nanomaterials are being developed from more traditional polymeric constructs. Specifically, nanostructured hydrogels are emerging as a promising group of materials for multiple biotechnology applications as the need for advanced materials in the post‐genomic era grows. This review will present some of the recent advances in the marriage between water‐swellable networks and nanoscience.
Unsupervised Learning of Dense Optical Flow, Depth and Egomotion from Sparse Event Data (2018)

In this work we present a lightweight, unsupervised learning pipeline for \textit{dense} depth, optical flow and egomotion estimation from sparse event output of the Dynamic Vision Sensor (DVS). To tackle this low level vision task, we use a novel encoder-decoder neural network architecture - ECN. Our work is the first monocular pipeline that generates dense depth and optical flow from sparse event data only. The network works in self-supervised mode and has just 150k parameters. We evaluate our pipeline on the MVSEC self driving dataset and present results for depth, optical flow and and egomotion estimation. Due to the lightweight design, the inference part of the network runs at 250 FPS on a single GPU, making the pipeline ready for realtime robotics applications. Our experiments demonstrate significant improvements upon previous works that used deep learning on event data, as well as the ability of our pipeline to perform well during both day and night.
Vaginal Wall Descensus and Pelvic Floor Symptoms in Older Women (2005)

Vaginal support defects in older women are associated with obstructive urinary symptoms and the symptom of seeing or feeling a bulge. However, symptoms are not useful in discriminating between women with and without milder vaginal wall descensus. Based on these results, we suggest that other etiologies for bothersome bladder or bowel complaints be considered before performing surgery for early pelvic organ prolapse.
Modification of targets related to the Entner–Doudoroff/pentose phosphate pathway route for methyl-d-erythritol 4-phosphate-dependent carotenoid biosynthesis in Escherichia coli (2015)

An efficient and balanced MEP-dependent carotenoid bioconversion strategy involving both the ED and PP pathways was implemented by the coordinated modification of diverse central metabolic pathway targets. In this strategy, enhancement of the ED pathway for efficient G3P and pyruvate turnover was crucial for carotenoid production. The anaplerotic role of the PP pathway was important to supply precursors for the ED pathway. A balanced metabolic flux distribution among precursor supply, NADPH generation, and by-product pathways was established.
ARM TrustZone for Secure Image Processing on the Cloud (2016)

Nowadays, offloading storage and processing capacity to cloud servers is a growing trend. This happens because high storage capacity and powerful processors are expensive, whilst cloud services provide a cheaper, ongoing, and reliable solution. The problem with cloud-based solutions is that servers are highly accessible through the Internet and therefore considerably exposed to hackers and malware. In this paper, we design and implement Darkroom, a secure image processing service for the cloud leveraging ARM TrustZone technology. Our system enables users to securely process image data in a secure environment that prevents exposure of sensitive data to the operating system. We evaluate our system and observe that our solution adds a small overhead to image processing when compared to computer platforms that require the entire operating system to be trusted.