gebhart/patrepeval huggingface dataset:
Circulating Immune Complexes in the Serum in Systemic Lupus Erythematosus and in Carriers of Hepatitis B Antigen QUANTITATION BY BINDING TO RADIOLABELED Clq (1974)

A sensitive and reproducible procedure for the detection of soluble immune complexes in sera from patients with various immunopathological disorders is reported. Radiolabeled C1q is reacted with sera containing immune complexes. Separation of free from complex bound [(125)I]C1q is achieved by selective precipitation with polyethylene glycol (PEG). The method is based on both the large molecular size and the C1q-binding property characterizing immune complexes. The minimal amount of aggregated immunoglobulins thus detected is about 10 mug and that of soluble human IgG-anti-IgG complexes is about 3 mug of complexed antibody. Some immune complexes formed in large antigen excess (Ag(2)Ab) can still be detected by this radiolabeled C1q binding assay. The specificity of the radiolabeled C1q binding test was documented by the inability of antigen-F(ab')(2) antibody complexes to lead to a precipitation of [(125)I]C1q in PEG. In a second step, this radiolabeled C1q binding assay was applied to an experimental model of immune complex disease and was shown to be efficient for the detection of in vivo formed immune complexes.Finally, the technique could be applied to the study of sera from patients with systemic lupus erythematosus (SLE) or to carriers of the hepatitis B antigen (HB-Ag). Significantly increased [(125)I]-C1q binding values were observed in 52 sera from SLE patients when compared to values obtained with healthy blood donors (P<0.001). Particularly high values were seen in active disease, a finding which was confirmed by follow-up studies performed with four SLE patients. No increased [(125)I]C1q binding was seen in 18 healthy carriers of the HB-Ag; whereas, sera from carriers with hepatitis appear to precipitate increased [(125)I]C1q percentages: 7/24 cases with acute transient and 4/7 cases with chronic persistent hepatitis were found to increasingly bind [(125)I]C1q. The results were also used for a correlative study of [(125)I]C1q binding to IgG levels in the sera but increased [(125)I]C1q binding could not be attributed to high serum IgG levels which are likely to account for gammaglobulin aggregates. These examples suggest the utility of the radiolabeled C1q binding assay for the evaluation of immune complex diseases in human pathology.
A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0·02% tretinoin product regimen (2009)

An appropriately designed cosmetic regimen can improve facial wrinkle appearance comparably with the benchmark prescription treatment, with improved tolerability.
Intron sequence directs RNA editing of the glutamate receptor subunit GluR2 coding sequence. (1994)

The Ca2+ permeability and the rectifying properties of the glutamate receptors assembled from the subunits GluR1-GluR4 depend upon a critical Arg in the GluR2 subunit located in a domain that has been proposed to span the membrane. The GluR2 subunit gene encodes a Gln (CAG) at this position, whereas the mRNA is edited so that it encodes an Arg (CGG) at this position [Sommer, B., Kohler, M., Sprengel, R. & Seeburg, P. H. (1991) Cell 67, 11-20]. The editing process is specific since only the GluR2 subunit RNA is edited even though the GluR1, GluR3, and GluR4 RNAs have a similar sequence. We show that this selective RNA editing depends upon a critical intron sequence in the GluR2 gene. This critical intron sequence is sufficient to cause editing of the GluR3 subunit exon in a chimera minigene constructed so that the GluR3 exon is placed upstream to the GluR2 intron sequence. Transfections of a neuronal cell line, N2a, with minigene constructs encoding different fragments of the GluR2 gene demonstrate that the 5' part of the 3' intron is essential for editing. Part of the exon and this critical intron sequence contains an inverted repeat that can fold into a structure consisting of three helical elements. Similar conclusions were reached by Higuchi, M., Single, F. n., Köhler, M., Sommer, B., Sprengel, R. & Seeburg, P. H. [(1993) Cell 75, 1361-1370]. These experiments demonstrate that the low Ca2+ permeability of the ionotropic non-N-methyl-D-aspartate glutamate receptors depends upon RNA editing, which requires a sequence in an intron 3' to the exon.
Abnormalities of Myelination of the Central Nervous System Associated With Congenital Tremor (1987)

ABNORMALITIES of development of myelin in the nervous system associated with congenital tremor have now been documented in a number of species. Myelin, which is a ubiquitous substance throughout the nervous system, is an insulator of axons of both the central nervous system (CNS) and peripheral nervous system (PNS).' It is essential for the normal conduction of nerve impulses and therefore for the functioning of the nervous system as a whole.
Distributed similarity search in high dimensions using locality sensitive hashing (2009)

In this paper we consider distributed K-Nearest Neighbor (KNN) search and range query processing in high dimensional data. Our approach is based on Locality Sensitive Hashing (LSH) which has proven very efficient in answering KNN queries in centralized settings. We consider mappings from the multi-dimensional LSH bucket space to the linearly ordered set of peers that jointly maintain the indexed data and derive requirements to achieve high quality search results and limit the number of network accesses. We put forward two such mappings that come with these salient properties: being locality preserving so that buckets likely to hold similar data are stored on the same or neighboring peers and having a predictable output distribution to ensure fair load balancing. We show how to leverage the linearly aligned data for efficient KNN search and how to efficiently process range queries which is, to the best of our knowledge, not possible in existing LSH schemes. We show by comprehensive performance evaluations using real world data that our approach brings major performance and accuracy gains compared to state-of-the-art.
Research on Application of Development Method of Knowledge Base in the Integrated System for ICAD (2005)

Making a research of hybrid knowledge representation that is integrated organically by rule, frame and procedure, hierarchical knowledge base model, strategy of multilevel knowledge acquisition and object oriented inferential mechanism. Knowledge frame and generic form of knowledge representation were present, as was instanced by cylindrical gearing design. The purpose is to put forward an effective method and implement for the establishment of knowledge base in the development of the integrated system for ICAD.
The Use of the Pain Drawing As a Screening Measure to Predict Psychological Distress in Chronic Low Back Pain (1995)

Using the new scoring systems, it was not possible to identify distressed patients with sufficient sensitivity/specificity, nor to differentiate between organic and nonorganic pain patterns.
Switching operation and degradation of resistive random access memory composed of tungsten oxide and copper investigated using in-situ TEM (2015)

In-situ transmission electron microscopy (in-situ TEM) was performed to investigate the switching operation of a resistive random access memory (ReRAM) made of copper, tungsten oxide and titanium nitride (Cu/WOx/TiN). In the first Set (Forming) operation to initialize the device, precipitation appeared inside the WOx layer. It was presumed that a Cu conducting filament was formed, lowering the resistance (on-state). The Reset operation induced a higher resistance (the off-state). No change in the microstructure was identified in the TEM images. Only when an additional Reset current was applied after switching to the off-state could erasure of the filament be seen (over-Reset). Therefore, it was concluded that structural change relating to the resistance switch was localized in a very small area around the filament. With repeated switching operations and increasing operational current, the WOx/electrode interfaces became indistinct. At the same time, the resistance of the off-state gradually decreased. This is thought to be caused by Cu condensation at the interfaces because of leakage current through the area other than through the filament. This will lead to device degradation through mechanisms such as endurance failure. This is the first accelerated aging test of ReRAM achieved using in-situ TEM.
Reconstitution into liposomes of highly purified PO glycoprotein from avian peripheral nerve myelin (1990)

To explore the adhesive, possibly fusogenic properties of the major protein of peripheral nerve myelin (PO protein), three methods were employed for the reconstitution of this glycoprotein into liposomes of various lipid compositions. The most successful technique for the preparation of proteoliposomes was a detergent solubilization that employed Bio-Beads for the removal of Triton X-100 from the PO protein – lipid – detergent mixture. This method yielded a similar level of PO protein relative to lipids in the liposomes to that found in myelin. The protein to lipid ratio of the reconstituted proteoliposomes was only 1.4-fold lower than the initial protein to lipid ratio employed to prepare the liposomes. In contrast, the solvent evaporation and reverse-phase evaporation methods provided liposomes with 30 times lower protein to lipid ratio when compared with PO protein to lipid ratio initially used for the preparation of proteoliposomes. The incorporation of PO protein was dependent on the lipid composition of the vesicles and on the degree of purification of the protein. Proteolytic enzyme treatment showed that proteoliposomes containing the highly purified form of PO protein were partially or completely sensitive to trypsin treatment, whereas in liposomes containing a partially purified form of PO protein, a 22.4-kilodalton fragment was completely protected from trypsin digestion, indicating a transmembrane orientation of the partially purified polypeptide. Endoglycosidase F treatment of the liposomes established that all of the oligosaccharide moieties were removed from the liposome-associated protein, indicating the oligosaccharide moiety was exposed to the outside surface of the liposomes. Taken together, the results of limited proteolysis and endoglycosidase treatments did not provide strong evidence for the transmembrane orientation of highly purified PO in the liposomes, but were consistent with a surface of partial hairpin configuration, where the extracellular domains are facing the outside milieu. Electron microscopic examinations revealed highly convoluted, elongated shapes arid extensive fusion of PO liposomes containing lipids capable of adopting the hexagonal (H 11 ) phase. Proteoliposomes prepared with the simple lipid composition of dipalmitoyl phosphatidylcholine -cholesterol (10:1 molar ratio) yielded stable, unilamellar liposomes of 80 nm average diameter, that encapsulated water-soluble drugs efficiently into the intravesicular compartment.Key words: liposomes, PO glycoprotein, myelin, peripheral nerve.
Non-invasive sensing of the electrical energy harvested by medical implants powered by an ultrasonic transcutaneous energy transfer link (2012)

Ultrasonic transcutaneous energy transfer is an effective tool for powering medical implanted devices non-invasively. The power harvested by the implanted receiver is sensitive to the distance between the transmitting and receiving transducers, and to the orientation of one with respect to the other. This work describes an inductive link as a means for the contactless measurement of the voltage generated by the ultrasonically powered implanted transducer. A closed form analytic expression of the proposed sensor is presented. The sensor was successfully simulated for an implantation depth of up to 50 mm, achieving a voltage measurement accuracy of +/- 5%. The simulation is performed by exciting an external coil attached on the skin (50 mm diameter) by an AC current source (0.01 A). The excitation frequency is swept in the range of 2-6 MHz, the peak voltage across the current-source is then measured, and the resonance frequency is correlated to the equivalent inductive link impedance.
Über oligomere Siliciumverbindungen mit funktionellen Gruppen. 12. Mitt. Über Herstellung von oligomeren siliciumorganischen Diolen und Diaminen und ihre Umsetzungen mit organischen Diisocyanaten (1962)

Abstract Durch Addition der ω,ω′‐Dihydropolysiloxane und ‐silmethylene an Trimethylallyl‐oxysilan in Gegenwart von H 2 PtCl 6 und nachfolgende saure Abspaltung der Trimethylsiloxygruppen wurden die ω,ω′‐Bis‐(γ‐hydroxypropyl)‐polysiloxane und ‐silmethylene der Formel I, (R = (CH 2 ) 3 OH) hergestellt: magnified image Daneben bildeten sich auch die Monoalkohole mit einer SiH‐Endgruppe, Formel I (R = H). Durch Addition der ω,ω′‐Dihydropolysiloxane an Benzylidenallylamin in Gegenwart von H 2 PtCl 6 wurden die entsprechenden Di‐ und auch Monoadditionsprodukte erhalten. Bei der sauren Hydrolyse der Di‐SCHIFFschen Basen entstanden die ω,ω′‐Bis‐(γ‐aminopropyl)‐polysiloxane der Formel II: magnified image Die siliciumorganischen Diole der Formel I (R = (CH 2 ) 3 OH) wurden mit verschiedenen organischen Diisocyanaten im Molverhältnis 1:1 polyaddiert, wobei Polyurethane mit Molekulargewichten von etwa 2200 bis 5500 erhalten wurden. Bei den Umsetzungen der Polysiloxandiole der Formel I (R = (CH 2 ) 3 OH) mit 1,4‐Phenylendiisocyanat im Molverhältnis 1:1,5 und 1:2 erhielten wir Polyurethane mit zwei Isocyanat‐Endgruppen der Formel III magnified image und Polyadditionsgraden von ȳ ∼︁ 2–5. Diese Polyurethane rnit zwei Isocyanatgruppen wurden mit 1,3‐Bis‐(γ‐aminopropyl)‐disiloxan, Formel II (n = 1), zu höhermolekularen Produkten mit Harnstoffgruppen umgesetzt.
The development of helper T cell precursors in mouse thymus. (1988)

We have examined the appearance in mouse ontogeny of thymocyte precursors for Ag-specific, MHC-restricted Th. These cells are first detectable at day 18 of fetal life, about 1 day after alpha/beta, TCR-positive cells begin to appear. These early Th precursors are not dependent on the thymus for priming with Ag and MHC, and are L3T4+, Lyt-2-. Thus, these cells already have the phenotype of mature Th. In neonatal F1 animals expressing both IAk and IAb, the appearance of Th precursors restricted by either IAk or IAb is specifically inhibited by treatment of the mice with anti-IAk or anti-IAb antibodies, respectively. These results indicate that cells of mature T cell phenotype and function can arise fairly rapidly from immature, receptor-bearing precursors, once these appear. Moreover the results are in line with those previously obtained in chimeric animal experiments which suggested that specific interaction of TCR on thymocytes with class II alleles in the thymus is required for the subsequent appearance of T cells restricted by those class II alleles.
Two-layer thermal barrier coating for turbine airfoils - furnace and burner rig test results (1976)

Allogeneic HSCT markedly improved the prognosis of patients with intermediate risk of relapse of ALL and unsatisfactory MRD response. As a result, outcomes in this group approximated those of patients with favorable MRD response. Patients with early combined relapse require treatment intensification even in case of favorable MRD response, demonstrating the prognostic impact of time to relapse.
Human Immunodeficiency Virus Type 1 Tat Binding Protein-1 Is a Transcriptional Coactivator Specific for TR (2001)

The DNA-binding domain of nuclear hormone receptors functions as an interaction interface for other transcription factors. Using the DNA-binding domain of TRβ1 as bait in the yeast two-hybrid system, we cloned the Tat binding protein-1 that was originally isolated as a protein binding to the human immunodeficiency virus type 1 Tat transactivator. Tat binding protein-1 has subsequently been identified as a member of the ATPase family and a component of the 26S proteasome. Tat binding protein-1 interacted with the DNA-binding domain but not with the ligand binding domain of TR in vivo and in vitro. TR bound to the amino-terminal portion of Tat binding protein-1 that contains a leucine zipper-like structure. In mammalian cells, Tat binding protein-1 potentiated the ligand-dependent transactivation by TRβ1 and TRα1 via thyroid hormone response elements. Both the intact DNA-binding domain and activation function-2 of the TR were required for the transcriptional enhancement in the presence of Tat binding protein-1. Tat binding protein-1 did not augment the transactivation function of the RAR, RXR, PPARγ, or ER. The intrinsic activation domain in Tat binding protein-1 resided within the carboxyl-terminal conserved ATPase domain, and a mutation of a putative ATP binding motif but not a helicase motif in the carboxyl-terminal conserved ATPase domain abolished the activation function. Tat binding protein-1 synergistically activated the TR-mediated transcription with the steroid receptor coactivator 1, p120, and cAMP response element-binding protein, although Tat binding protein-1 did not directly interact with these coactivators in vitro. In contrast, the N-terminal portion of Tat binding protein-1 directly interacted in vitro and in vivo with the TR-interacting protein 1 possessing an ATPase activity that interacts with the activation function-2 of liganded TR. Collectively, Tat binding protein-1 might function as a novel DNA-binding domain-binding transcriptional coactivator specific for the TR probably in cooperation with other activation function-2-interacting cofactors such as TR-interacting protein 1.
Child with Sotos phenotype and a 5:15 translocation (1994)

We report on a 4-year-old girl with Sotos phenotype and a de novo balanced translocation between the long arms of chromosome 5 and chromosome 15 [46,XX,t(5,15)(q35;q22)]. We suggest a relationship between genetic material at 5q35 or 15q22 and the expression of an autosomal dominant gene.
Segment Based Indexing Technique for Video Data File (2016)

A video is an effective tool to exchange the information in the structure of showing the brief text message due to the advance developed technology. Video capturing is effortless process but the related video retrieval is the difficult process, for that process the videos must be indexed. Retrieval is the method that retrieved a video using a user query. The query will be image or texts depend upon the query result output system that returned a particular video or image based on that query. In this project we create a indexing for video file by using segment based indexing technique. Here video will be divided into a hierarchy which is in storyboards of film making. For instance, a hierarchical based video search is composed into multi stage abstraction for assist the users to locate the specific video segments/frames logically. This paper brings out the reduced bandwidth and reduced delays the video through the network of searching and reviewing. Experimental results verify this.
A MATLAB package for the EIDORS project to reconstruct two-dimensional EIT images (2001)

The EIDORS (electrical impedance and diffuse optical reconstruction software) project aims to produce a software system for reconstructing images from electrical or diffuse optical data. MATLAB is a software that is used in the EIDORS project for rapid prototyping, graphical user interface construction and image display. We have written a MATLAB package (http://venda.uku.fi/ vauhkon/) which can be used for two-dimensional mesh generation, solving the forward problem and reconstructing and displaying the reconstructed images (resistivity or admittivity). In this paper we briefly describe the mathematical theory on which the codes are based on and also give some examples of the capabilities of the package.
Performance analysis of embedded software using implicit path enumeration (1997)

Embedded computer systems are characterized by the presence of a processor running application-specific dedicated software. A large number of these systems must satisfy real-time constraints. This paper examines the problem of determining the extreme (best and worst) case bounds on the running time of a given program on a given processor. This has several applications in the design of embedded systems with real-time constraints. An important aspect of this problem is determining which paths in the program are exercised in the extreme cases. The state-of-the-art solution here relies on an explicit enumeration of program paths. This solution runs out of steam rather quickly since the number of feasible program paths is typically exponential in the size of the program. We present a solution for this problem that does not require an explicit enumeration of program paths, i.e., the paths are considered implicitly. This solution is implemented in the program cinderella (in recognition of her hard real-time constraint-she had to be back home at the stroke of midnight), which currently targets a popular embedded processor-the Intel i960. The preliminary results of using this tool are also presented here.
Leakage power analysis and reduction during behavioral synthesis (2002)

This paper presents a high-level leakage power analysis and reduction algorithm. The algorithm uses device-level models for leakage to pre-characterize a given register-transfer level module library. This is used to estimate the power consumption of a circuit due to leakage. The algorithm can also identify and extract the frequently idle modules in the datapath, which may be targeted for low-leakage optimization. Leakage optimization is based on the use of dual threshold voltage (V/sub T/) technology. The algorithm prioritizes modules giving a high level synthesis (HLS) system an indication of where most gains for leakage reduction may be found. Results show that using a dual-V/sub T/ library during HLS can reduce leakage power by an average of 59% for the different technology generations. Total power can be reduced by an average of 18.8% to 45.4% for 0.18 /spl mu/m to 0.07 /spl mu/m technologies, respectively, compared to register-transfer level (RTL) circuits optimized for switching power only. The contribution of leakage power to overall power consumption of switching power optimized RTL circuits ranges from 23.5% to 54.1%. Our approach reduced these values to 11.4% to 25.9%.
The role of the <i>LRPPRC</i> (leucine-rich pentatricopeptide repeat cassette) gene in cytochrome oxidase assembly: mutation causes lowered levels of COX (cytochrome <i>c</i> oxidase) I and COX III mRNA (2004)

Leigh syndrome French Canadian (LSFC) is a variant of cytochrome oxidase deficiency found in Québec and caused by mutations in the LRPPRC (leucine-rich pentatricopeptide repeat cassette) gene. Northern blots showed that the LRPPRC mRNA levels seen in skeletal muscle>heart>placenta>kidney>liver>lung=brain were proportionally almost opposite in strength to the severity of the enzymic cytochrome oxidase defect. The levels of COX (cytochrome c oxidase) I and COX III mRNA visible on Northern blots were reduced in LSFC patients due to the common (A354V, Ala354-->Val) founder mutation. The amount of LRPPRC protein found in both fibroblast and liver mitochondria from LSFC patients was consistently reduced to <30% of control levels. Import of [(35)S]methionine LRPPRC into rat liver mitochondria was slower for the mutant (A354V) protein. A titre of LRPPRC protein was also found in nuclear fractions that could not be easily accounted for by mitochondrial contamination. [35S]Methionine labelling of mitochondrial translation products showed that the translation of COX I, and perhaps COX III, was specifically reduced in the presence of the mutation. These results suggest that the gene product of LRPPRC, like PET 309p, has a role in the translation or stability of the mRNA for mitochondrially encoded COX subunits. A more diffuse distribution of LRPPRC in LSFC cells compared with controls was evident when viewed by immunofluorescence microscopy, with less LRPPRC present in peripheral mitochondria.