gebhart/patrepeval huggingface dataset:
A novel antifungal protein of Bacillus subtilis B25 (2013)

Bacillus subtilis B25 was isolated from banana rhizosphere soil. It has been confirmed for B25 to have stronger antagonism against Fusarium oxysporum f.sp.cubense, Additionally B25 has good inhibitory to plant pathogens, including Corynespora cassiicola, Alternaria solani, Botrytis cinerea and Colletotrichum gloeosporioides on potato dextrose agar (PDA) plates. The antagonistic substance can be extracted from cell-free culture broth supernatants by 70% (w/v) (NH4)2 SO4 saturation. Clear blank band was observed between the protein and a pathogen. The examination of antagonistic mechanism under light microscope showed that the antifungal protein of B25 appeared to inhibit pathogens by leading to mycelium and spores tumescence, distortion, abnormality. The isolation procedure comprised ion exchange chromatography on DEAE-Sephadex Fast Flow and gel filtration chromatography on SephadexG-100. The purified antifungal fraction showed a single band in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The active fraction was identified by NanoLC-ESI-MS/MS The amino acid sequences of 17 peptides segments were obtained. The analysis of the protein suggested that it was a hypothetical protein (gi154685475), with a relative molecular mass of 38708.67 Da and isoelectric point (pI) of 5.63.
Forthcoming conferences (2019)

research-article Share on Forthcoming conferences Author: SIGEVO Staff View Profile Authors Info & Claims ACM SIGEVOlutionVolume 11Issue 4December 2018 pp 13–16https://doi.org/10.1145/3302542.3302545Published:02 January 2019Publication History 0citation16DownloadsMetricsTotal Citations0Total Downloads16Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Concurrent error recovery with near-zero latency in synthesized ASICs (1998)

The importance of fault tolerant design has been steadily increasing as reliance on error free electronics continues to rise in critical military, medical, and automated transportation applications. While rollback and checkpointing techniques facilitate area efficient fault tolerant designs, they are inapplicable to a large class of time-critical applications. We have developed a novel synthesis methodology that avoids rollback, and provides both zero reduction in throughput and near-zero error latency. In addition, our design techniques reduce power requirements associated with traditional approaches to fault tolerance.
Jewels of Stringology (2002)

Contents: Stringology Basic String Searching Algorithms Preprocessing for Basic Seachings On-Line Construction of Suffix Trees More on Suffix Trees Subword Graphs Text Algorithms Related to Sorting Symmetries and Repetitions in Texts Constant-Space Searchings Text Compression Techniques Automata-Theoretic Approach Approximate Pattern Matching Matching by Dueling and Sampling Two-Dimensional Pattern Matching Two-Dimensional Periodicities Parallel Text Algorithms Miscellaneous.
Alterations in growth requirements of kidney epithelial cells in defined medium associated with malignant transformation (1981)

The possibility has been investigated that 1) the supplements required for the growth of the Madin Darby Canine Kidney (MDCK) cell line in serum-free Medium K-1 are indeed requirements for the growth of normal kidney cells in vitro, and 2) that alterations in these growth requirements are associated with malignant transformation. Consistent with the hypothesis that MDCK cells resemble normal kidney cells in culture, primary cultures of baby mouse kidney epithelial cells grow in Medium K-1 and respond to the 5 components in the medium. The growth properties of Moloney sarcoma virus (MSV)-transformed MDCK cells in defined media have been examined. Unlike MDCK cells, MSV-transformed MDCK cells form tumors in adult nude mice. Although they still respond to the 5 factors in Medium K1, the optimal dosage for insulin is lower for the MSV transformants than for MDCK cells. The MSV transformants also have an additional requirement for growth in Medium K-1-fibronectin. Variants of MDCK cells have been isolated that have lost the PGE1 requirement for growth in defined medium. These variant cells have acquired 1) the ability to form tumors in adult nude mice and 2) an alteration affecting cAMP metabolism, in addition to PGE1 independence.
A Novel Piggyback Selection Scheme in IEEE 802.11e HCCA (2008)

A control frame can be piggybacked onto a data frame to increase channel efficiency in wireless communication. However, if the control frame including global control information is piggybacked, the delay of the data frame from a access point will be increased even though there is only one station with low physical transmission rate. It is similar to the anomaly phenomenon in a network which supports multi-rate transmission. In this letter, we define this phenomenon as “the piggyback problem at low physical transmission rate” and evaluate the effect of this problem with respect to physical transmission rate and normalized traffic load. Then, we propose a delay-based piggyback scheme. Simulations show that the proposed scheme reduces average frame transmission delay and improves channel utilization about 24% and 25%, respectively.
Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, ameliorates type 2 diabetes via reduced gluconeogenesis (2022)

PDK inhibitor may be considered as a potential antidiabetic agent harboring inhibitory effect on gluconeogenesis.
Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity (2010)

Oral medicines and food constituents are absorbed in the intestine and metabolized in the liver, after which they exhibit their activity toward a target tissue. Micromodels of human tissues were developed to mimic these processes and bioactivities. By integrating the micromodels, we realized a micro total bioassay system for oral substances; this system comprised a microintestine, microliver, and the target components. The microchip was composed of a slide glass and polydimethylsiloxane (PDMS) sheets with microchannels fabricated by photolithography. Caco-2 cells were cultured in the intestine component, and HepG2 cells, in the liver component. The human breast carcinoma MCF-7 cells were cultured in the target component, and the activities of anticancer agents and estrogen-like substances were successfully assayed. By using this system, the overall properties of the ingested cyclophosphamide, epirubicin, 17-β estradiol, and soy isoflavone, i.e., their intestinal absorption, hepatic metabolism, and bioactivity toward target cells, could be assayed with operative ease. Further, the assay time and cell consumption were reduced compared to those in conventional in vitro bioassay systems.
Redox-Gated Three-Terminal Organic Memory Devices: Effect of Composition and Environment on Performance (2013)

The performance of redox-gated organic nonvolatile memory (NVM) based on conducting polymers was investigated by altering the polymer structure, composition, and local environment of three-terminal devices with a field-effect transistor (FET) geometry. The memory function was dependent on the presence of a redox active polymer with high conducting and low conducting states, the presence of a redox counter-reaction, and the ability to transport ions between the polymer and electrolyte phases. Simultaneous monitoring of both the "write" current and "readout" current revealed the switching dynamics of the devices and their dependence on the local atmosphere. Much faster and more durable response was observed in acetonitrile vapor than in a vacuum, indicating the importance of polar molecules for both ion motion and promotion of electrochemical reactions. The major factor determining "write" and "erase" speeds of redox-gated polymer memory devices was determined to be the rate of ion transport through the electrolyte layer to provide charge compensation for the conducting polarons in the active polymer layer. The results both confirm the mechanism of redox-gated memory action and identify the requirements of the conducting polymer, redox counter reaction, and electrolyte for practical applications as alternative solid-state nonvolatile memory devices.
Theoretical accuracy of synthetic aperture sonar micronavigation using a displaced phase-center antenna (2002)

The Cramer-Rao lower bounds on the cross-track translation and rotation of a displaced phase-center antenna (DPCA) in the slant range plane between two successive pings (known as DPCA sway and yaw in what follows) are computed, assuming statistically homogeneous backscatter. These bounds are validated using experimental data from a 118-182-kHz sonar, showing an accuracy of the order of 20 microns on the ping-to-ping cross-track displacements. Next, the accuracy required on the DPCA sway and yaw in order to achieve a given synthetic aperture sonar (SAS) beampattern specification, specified by the expected SAS array gain, is computed as a function of the number P of pings in the SAS. Higher accuracy is required when P increases to counter the accumulation of errors during the integration of the elementary ping-to-ping estimates: the standard deviation must decrease as P/sup -1/2/ for the DPCA sway and P/sup -3/2/ for the yaw. Finally, by combining the above results, the lower bounds on DPCA micronavigation accuracy are established. These bounds set an upper limit to the SAS length achievable in practice. The maximum gain Q in cross-range resolution achievable by a DPCA micronavigated SAS is computed as a function of the key SAS parameters. These theoretical predictions are compared with simulations and experimental results.
How sensitive are online gamers to network quality? (2006)

Game-playing time is strongly related to network QoS, helping determine user satisfaction and deliver better service quality to online gamers.
Contrast agent techniques (2009)

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It’s Not Just Size That Matters: Small Language Models Are Also Few-Shot Learners (2021)

When scaled to hundreds of billions of parameters, pretrained language models such as GPT-3 (Brown et al., 2020) achieve remarkable few-shot performance. However, enormous amounts of compute are required for training and applying such big models, resulting in a large carbon footprint and making it difficult for researchers and practitioners to use them. We show that performance similar to GPT-3 can be obtained with language models that are much "greener" in that their parameter count is several orders of magnitude smaller. This is achieved by converting textual inputs into cloze questions that contain a task description, combined with gradient-based optimization; exploiting unlabeled data gives further improvements. We identify key factors required for successful natural language understanding with small language models. 1
Automatic generation of programming exercises for learning programming language (2015)

Not only knowledge such as the grammar but also practical programming experiences are important to the learning of the programming language. In this paper, we classify programming exercises into the following two types: 1) syntax practices for understanding the grammar and 2) semantics practices for understanding the flow of a program, and then we develop a web-base application that automatically generates programming exercises by using templates and PHP language.We also confirm the effectiveness of the system by our preliminary experiments.
Normal blood cell values in the early mid‐trimester fetus (1985)

Samples of pure fetal blood from 116 fetuses of 15-21 weeks' gestation were obtained by direct vision fetoscopy. Ninety nine of these fetuses, presumed to be haematologically normal, were suitable for analysis. The data obtained show that the erythropoietic system is evolving rapidly in this gestational age range. The myeloid series shows no significant increase or decrease in numbers apart from eosinophils and basophils which increase significantly with gestational age whereas the platelet count remains constant. The growing application of fetoscopic blood sampling to the prenatal diagnosis and management of fetal blood disorders renders mandatory a knowledge of normal fetal blood values.
Incidence and recent trends in functional gastrointestinal disorders, active component, U.S. Armed Forces, 2005-2014. (2016)

Functional gastrointestinal disorders (FGIDs) are common chronic conditions with an unknown pathophysiology and etiology. FGIDs elevate healthcare costs and cause substantial burden to public health and the military, including diminished readiness, productivity, and quality of life. This retrospective cohort study of active component U.S. military personnel covered a 10-year surveillance period, 2005-2014. The Defense Medical Surveillance System (DMSS) was the data source. Incident cases were identified and rates were calculated and stratified by important covariates. Trends were described over the surveillance period. Incidence rates among deployed personnel were compared to rates in non-deployed personnel, stratified by age and sex. An increasing trend in functional constipation was observed during 2005-2012. Being female, black, in the Army or Air Force, and younger than 20 years of age or 40 years of age or older was associated with higher incidence rates. Deployment-exposed personnel had incidence rates that were 53% higher than those of non-deployed personnel. Elevated rates in personnel younger than 20 years of age and deployed personnel evoke interest concerning readiness and cost implications for the Military Health System. These subgroups should be examined in future studies.
Detection and classification of ground penetrating radar image using textrual features (2014)

Detection and classification of an object is of growing concern in many application areas. Ground Penetrating Radar (GPR) data has been widely used in fields like military, archeology, and geophysical exploration and many such applications. In this paper, we present a combination of Singular Value Decomposition (SVD) approach and Blob detector for detection of buried objects from ground penetrating radar (GPR) data. Classification is done using Speeded Up Robust Feature (SURF) and Support Vector Machine (SVM) classifiers for landmine identification. 3-Dimensional data is collected using GPR Vehicle Mounted system. Buried objects are detected using the proposed SVD and blob detector approach. The located buried objects are then classified to discriminate between landmines and other objects. Performance of the proposed system was evaluated for different kernels of SVM classifiers for a number of datasets collected for different targets and soil conditions.
Identification of a high‐affinity binding protein for a hepta‐β‐glucoside phytoalexin elicitor in soybean (1992)

A putative receptor protein for a hepta-beta-glucoside phytoalexin elicitor was identified by photoaffinity labeling of detergent-solubilized proteins from soybean root membranes. Incubation of partially purified beta-glucan-binding proteins with a photolabile 125I-labeled 2-(4-azidophenyl)ethyl-amino conjugate of the heptaglucoside elicitor, followed by irradiation with ultraviolet light (366 nm) resulted in specific labeling of a 70-kDa band in SDS/PAGE. Half-maximal inhibition of the 125I-labeling of the protein band by underivatized hepta-beta-glucoside was achieved by 15 nM heptaglucoside. Analysis of the affinity of radiolabel incorporation into the protein by ligand-saturation experiments, gave an apparent Kd value of 3 nM, in full agreement with the results from radioligand-binding studies. Good correlation was also observed between the amount of radiolabel incorporated into the protein and the binding activity of the fractions obtained at different stages in the purification of heptaglucoside-binding activity. Photoaffinity labeling of proteins purified by glucan-affinity chromatography showed the 70-kDa band as the main component along with weak 125I-labeling of a 100-kDa band. The 70-kDa band was also the major protein visualized by silver staining after SDS/PAGE of this fraction, suggesting that it is the predominant form of the heptaglucoside-binding proteins in detergent-solubilized soybean membranes.
An immersive system for browsing and visualizing surveillance video (2010)

HouseFly is an interactive data browsing and visualization system that synthesizes audio-visual recordings from multiple sensors, as well as the meta-data derived from those recordings, into a unified viewing experience. The system is being applied to study human behavior in both domestic and retail situations grounded in longitudinal video recordings. HouseFly uses an immersive video technique to display multiple streams of high resolution video using a realtime warping procedure that projects the video onto a 3D model of the recorded space. The system interface provides the user with simultaneous control over both playback rate and vantage point, enabling the user to navigate the data spatially and temporally. Beyond applications in video browsing, this system serves as an intuitive platform for visualizing patterns over time in a variety of multi-modal data, including person tracks and speech transcripts.
PKD2 mutations in a Czech population with autosomal dominant polycystic kidney disease (2004)

In this study in the Czech population we identified 22 mutations (six of which were new mutations). The prevalence of PKD2 cases was 18-20% and the mean age of ESRF was 68.3 years. An at-least weak hot spot in exon 1 of the PKD2 gene was found.
Drugging the Cancer Stem Cell Compartment: Lessons Learned from the Hedgehog and Wnt Signal Transduction Pathways (2011)

Cell-cell communication mediated by the secreted Hedgehog (Hh) and Wnt signaling molecules is essential to the coordination of cell fate decision making throughout the metazoan lifespan. From decades of genetically based interrogation, core components constituting the Hh and Wnt signal transduction pathways have been assembled, and a deep appreciation of how these signals elaborate distinct bodily tissues during development has been established. On the other hand, our incapacity to leverage similar genetic approaches to study adult organ systems has limited our understanding of how these molecules promote tissue renewal and regeneration through stem cell regulation. We discuss recent progress in the use of chemically based approaches to achieve control of these pathway activities in a broad range of biological studies and therapeutic contexts. In particular, we discuss the unique experimental opportunities that chemical modulators of these pathways afford in exploring the cancer stem cell hypothesis.
Ectopic expression of a wheat MYB transcription factor gene, TaMYB73, improves salinity stress tolerance in Arabidopsis thaliana (2011)

MYB transcription factors (TFs) play pivotal roles in the abiotic stress response in plants, but their characteristics and functions in wheat (Triticum aestivum L.) have not been fully investigated. A novel wheat MYB TF gene, TaMYB73, is reported here based on the observation that its targeting probe showed the highest salinity-inducibility level among all probes annotated as MYB TFs in the cDNA microarray. TaMYB73 is a R2R3 type MYB protein with transactivation activity, and binds with types I, II, and IIG MYB binding motifs. The gene was induced by NaCl, dehydration, and several phytohormones, as well as some stress-, ABA-, and GA-responsive cis-elements present in its promoter region. Its over-expression in Arabidopsis enhanced the tolerance to NaCl as well as to LiCl and KCl, whereas it had no contribution to mannitol tolerance. The over-expression lines had superior germination ability under NaCl and ABA treatments. The expression of many stress signalling genes such as AtCBF3 and AtABF3, as well as downstream responsive genes such as AtRD29A and AtRD29B, was improved in these over-expression lines, and TaMYB73 can bind with promoter sequences of AtCBF3 and AtABF3. Taken together, it is suggested that TaMYB73, a novel MYB transcription factor gene, participates in salinity tolerance based on improved ionic resistance partly via the regulation of stress-responsive genes.
Halide Ions Complex and Deprotonate Dipicolinamides and Isophthalamides: Assessment by Mass Spectrometry and UV−Visible Spectroscopy (2010)

The F(-), Cl(-), and Br(-) binding selectivity of bis(p-nitroanilide)s of dipicolinic and isophthalic acids was studied by using competitive electrospray mass spectrometry and UV-Visible spectroscopy. Both hosts prefer binding Cl(-) over either F(-) or Br(-). Host deprotonation was observed to some extent in all experiments in which the host was exposed to halide ions. When F(-) was present, host deprotonation was often the major process, whereas little deprotonation was observed by Cl(-) or Br(-), which preferred complexation. A solution of either host changed color when mixed with a F(-), H(2)PO(4)(-), di- or triphenylacetate solution.
Liquid simulation on lattice-based tetrahedral meshes (2007)

We describe a method for animating incompressible liquids with detailed free surfaces. For each time step, semi-Lagrangian contouring computes a new fluid boundary (represented as a fine surface triangulation) from the previous time step's fluid boundary and velocity field. Then a mesh generation algorithm called isosurface stuffing discretizes the region enclosed by the new fluid boundary, creating a tetrahedral mesh that grades from a fine resolution at the surface to a coarser resolution in the interior. The mesh has a structure, based on the body centered cubic lattice, that accommodates graded tetrahedron sizes but is regular enough to aid efficient point location and to save memory used to store geometric properties of identical tetrahedra. Although the mesh is warped to conform to the liquid boundary, it has a mathematical guarantee on tetrahedron quality, and is generated very rapidly. Each successive time step entails creating a new triangulated liquid surface and a new tetrahedral mesh. Semi-Lagrangian advection computes velocities at the current time step on the new mesh. We use a finite volume discretization to perform pressure projection required to enforce the fluid's incompressibility, and we solve the linear system with algebraic multigrid. A novel thickening scheme prevents thin sheets and droplets of liquid from vanishing when their thicknesses drop below the mesh resolution. Examples demonstrate that the method captures complex liquid motions and fine details on the free surfaces without suffering from excessive volume loss or artificial damping.
Pulsed Line Narrowing in Nitrogen‐14 NQR (1980)

Abstract On the basis of the average Hamiltonian theory the possibility of the pulsed narrowing of nitrogen 14 NQR lines in powders is studied theoretically using the fictitious spin‐(l/2) operator formalism. The modified Carr‐Purcell pulse sequence t (τ– t –2τ– t –τ) n is shown to be more acceptable for this purpose. The average Hamiltonians of inhomogeneous broadening and heteronuclear dipole‐dipole interactions as well as the secular part of the Hamiltonian of the interaction of a spin system with torsional oscillations of molecules are proved to commute with the initial density matrix prepared by the first (preparatory) pulse t The experimental curves of the spin echo envelopes in the pulse sequence are given. The decay time constants obtained experimentally at 77 K range between 0.5 s in methylamine and 10 s in sodium nitrite and agree with the spin–lattice relaxation times in these compounds.