gebhart/patrepeval huggingface dataset:
Educational patterns for generative participants: designing for creative learning (2013)

In, this paper, we propose a pattern language for Generative Participants. Recent education more and more requires methods to cultivate creativity in the students. A Generative Participant proposed in this paper is a teaching style aimed to cultivate creativity in its students. In a project-based environment, a Generative Participant teaches by actually participating in creative activities to stimulate the student's learning. Here we present four patterns for Generative Participants: Mining of Relationship, Learning Through Accidents, Showing the Art of Creation, and The Challenging Point. These patterns are meant for teachers, facilitators, and other educators. We believe our patterns would helpful to a practice of such educators.
A Basic Approach to Implement Guided Tractor Control (2008)

Within a continuous development of mobile agricultural machinery the application and further introduction of electronic controls is offering the fare most potential for working processes optimization. The article gives an introduction to tractor and implement controls, especially targeting implement guided tractor control, underlined with two executed examples for this advanced control design. A structured development model and basic knowledge on safe and robust control loop set-ups were developed. Potential conflict scenarios within the multi master control system of driver, tractor, implement and independently pre-planned task control were identified and solved by arbitrational state strategies. The two exemplarily executed demonstration examples utilize different control commands to functions and interfaces of the tractor. One example is an implement guided headland management; the other is a PTO torque guided tractor speed control. Both automation strategies have been pre-simulated and implemented introducing ISO 11783 communication protocol. Results from final field tests are closing the paper.
ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid‐β copathology (2019)

We conclude that ApoE4 accelerates neurodegeneration in FTD patients with <i>MAPT</i> mutations or FTLD-tau pathology, independent of Aβ.
Active atomic force microscopy cantilevers for imaging in liquids (2001)

We make an atomic force microscopy (AFM) cantilever oscillate by having an ac current circulating along it. When interacting with a permanent magnet, a normal force acts on the magnetic loop formed this way and induces its vibration. By choosing the current frequency at the resonance of the spring, this effect can be used for imaging in fluids in intermittent contact mode as demonstrated by an image of actin filaments in buffer. These active cantilevers can also be used in dc mode to reach a static position; they should be suitable for a parallel control of multiple probes.
Reputation-based Trust-Aware Recommender System (2006)

The volume of information available grows so large that it is time-consuming for people to find relevant reliable quality information. With the growth of online communities like Web boards and e-commerce communities, a new kind of information is made available - rating given by one user to another user. However, conventional recommender systems compute their recommendations regardless of the recommenders' past behaviors and reputation. They omit these significant social elements commonly done in decision making and advice seeking process in the real world. We propose an approach to include the social factors e.g. user's past behaviors and reputation together as an element of trust that can be incorporated into the current recommender system framework and show our experiments in order to test our solution
A commensal symbiotic factor derived from <i>Bacteroides fragilis</i> promotes human CD39 <sup>+</sup> Foxp3 <sup>+</sup> T cells and T <sub>reg</sub> function (2015)

Polysaccharide A (PSA) derived from the human commensal Bacteroides fragilis is a symbiosis factor that stimulates immunologic development within mammalian hosts. PSA rebalances skewed systemic T helper responses and promotes T regulatory cells (Tregs). However, PSA-mediated induction of Foxp3 in humans has not been reported. In mice, PSA-generated Foxp3(+) Tregs dampen Th17 activity thereby facilitating bacterial intestinal colonization while the increased presence and function of these regulatory cells may guard against pathological organ-specific inflammation in hosts. We herein demonstrate that PSA induces expression of Foxp3 along with CD39 among naïve CD4 T cells in vitro while promoting IL-10 secretion. PSA-activated dendritic cells are essential for the mediation of this regulatory response. When cultured with isolated Foxp3(+) Tregs, PSA enriched Foxp3 expression, enhanced the frequency of CD39(+)HLA-DR(+) cells, and increased suppressive function as measured by decreased TNFα expression by LPS-stimulated monocytes. Our findings are the first to demonstrate in vitro induction of human CD4(+)Foxp3(+) T cells and enhanced suppressive function of circulating Foxp3(+) Tregs by a human commensal bacterial symbiotic factor. Use of PSA for the treatment of human autoimmune diseases, in particular multiple sclerosis and inflammatory bowel disease, may represent a new paradigm in the approach to treating autoimmune disease.
Modification of Carbon Substrates by Aryl and Alkynyl Iodonium Salt Reduction (2010)

Different carbon materials were modified using iodonium ion reduction creating radicals, which after reaction with carbon surfaces formed grafted layers of molecules. Several molecules (4-bromophenyl, 4-fluorophenyl, 6-chlorohexyne, and 4-bromobutyne) were grafted on glassy carbon and Vulcan XC72 carbon substrates. Carbon substrates were shown to be free of halogen atoms; therefore, the quantification of the grafted groups containing halogen atoms was facilitated. The grafting of the different molecules was first electrochemically studied on glassy carbon electrodes using cyclic voltammetry, in order to determine the reduction potential of the corresponding iodonium ions. Voltammetric study using Fe(CN)(6)(4-) and Fe(CN)(6)(3-) probe molecules and XPS characterization were also used to evidence the effectiveness of grafting from iodonium ion reduction reaction. Reduction potentials were found in the range from -0.9 V vs SCE to -1.0 V vs SCE, lower than those for corresponding diazonium ion reduction reaction on glassy carbon (close to -0.3 V vs SCE). Therefore, grafted layers from iodonium ions were carried out on carbon Vulcan XC72 powder using NaBH(4) as reducing agent. Functionalized carbon powders were characterized by elemental analysis, thermogravimetric analysis, and X-ray photoelectron spectroscopy to evidence the presence of grafted molecules on the materials. However, low grafting yields were obtained. Then, several synthesis parameters were studied to optimize the grafting reactions, such as the control of the addition of reactants and their concentrations, leading to increase the surface concentration by a factor 2. At last, according to XPS measurements the grafting of alkinyliodonium ions led to very low surface concentrations (0.5 wt % for 6-chlorohexyne), whereas elemental analysis and TGA indicate ca. 2.4 wt % and ca. 5 wt %, respectively.
Twisted Network Programming Essentials (2005)

Twisted Network Programming Essentials from O'Reilly is a task-oriented look at this new open source, Python-based technology. The book begins with recommendations for various plug-ins and add-ons to enhance the basic package as installed. It then details Twisted's collection simple network protocols, and helper utilities. The book also includes projects that let you try out the Twisted framework for yourself. For example, you'll find examples of using Twisted to build web services applications using the REST architecture, using XML-RPC, and using SOAP. Written for developers who want to s
The EEG Analysis System of the National Cooperative Dialysis Study (1980)

As a renal patient's clinical condition deteriorates, slow-wave-related activity typically appears in the electroencephalogram (EEG) and disappears or is reduced as the clinical situation ameliorates. These changes can be quantitatively monitored by computer calculation of spectral estimates of the amount of slow-wave-related power in the EEG. The computer quantified EEG was used as one end point measure in the study of patients who participated in the National Cooperative Dialysis Study (NCDS). This study was designed to evaluate quantitative guidelines for administering dialysis therapy on a individualized basis.
Er3+ doped fibre amplifier temperature characteristics in extended and conventional band regions with gain control compensation (2000)

We propose compensation temperature dependence using a variable optical attenuator for an L-band amplifier operating under gain clamping condition.
Chemical Shift Standards in High-Resolution Solid-State NMR (1) 13C, 29Si, and 1H Nuclei (1991)

Abstract The resonance frequencies of 13C, 29Si, and 1H nuclei in pure tetramethylsilane have been measured accurately by spinning the liquid sample at the magic angle, which are free from the effects of the bulk magnetic susceptibility and the solvent. Using the above resonance positions, the chemical shifts of several second shift-standard materials have been determined with much improved accuracy and precision.
Noise removal from image data using recursive neuro-fuzzy filters (2003)

Neuro-fuzzy approaches are very promising for nonlinear filtering of noisy images. An original network topology is presented in this work to cope with different noise distributions and mixed noise as well. The multiple-output structure is based on recursive processing. It is able to adapt the filtering action to different kinds of corrupting noise. Fuzzy reasoning embedded into the network structure aims at reducing errors when fine details are processed. Genetic learning yields the appropriate set of network parameters from a collection of training data. Experimental results show that the proposed neuro-fuzzy technique is very effective and performs significantly better than well-known conventional methods in the literature.
Reducing Congestion over Hotspot Clusters in WCDMA Networks (2007)

Managing congestion is essential to maximise carried traffic in a mobile network and in this paper a technique is presented that uses learning to cooperatively change antenna patterns across a cluster of cells, so minimising blocking. Moreover, the technique allows prediction of antenna patterns, leading to more efficient operation as the optimum patterns do not have to be recalculated each time.
Increased M1/decreased M2 signature and signs of Th1/Th2 shift in chronic patients with bipolar disorder, but not in those with schizophrenia (2014)

We here present data on immune gene expression of chemokines, chemokine receptors, cytokines and regulatory T-cell (T-reg) markers in chronic patients suffering from either schizophrenia (SCZ, N=20) or bipolar disorder (BD=20) compared with healthy controls (HCs, N=20). We extracted RNA from peripheral blood mononuclear cells and performed real-time (RT)-PCR to measure mRNA levels of chemokines, chemokine receptors, cytokines and T-reg markers. All the analyses were Bonferroni-corrected. The classical monocyte activation (M1) markers il6, ccl3 were significantly increased in BD as compared with both HC and SCZ patients (P=0.03 and P=0.002; P=0.024 and P=0.021, respectively), whereas markers of alternative (M2) monocyte activation ccl1, ccl22 and il10 were coherently decreased (controls: P=0.01, P=0.001 and P=0.09; SCZ subjects: P=0.02, P=0.05 and P=0.011, respectively). Concerning T-cell markers, BD patients had compared with HC downregulated ccr5 (P=0.02) and upregulated il4 (P=0.04) and compared with both healthy and SCZ individuals downregulated ccl2 (P=0.006 and P=0.003) and tgfβ (P=0.004 and P=0.007, respectively). No significant associations were found between any immune gene expression and clinical variables (prior hospitalizations, Brief Psychiatric Rating Scale, medications' dosages and lifetime administration). Although some markers are expressed by different immune cell types, these findings suggest a coherent increased M1/decrease M2 signature in the peripheral blood of BD patients with potential Th1/Th2 shift. In contrast, all the explored immune marker levels were preserved in SCZ. Further larger studies are needed to investigate the relevance of inflammatory response in BD, trying to correlate it to psychopathology, treatment and outcome measures and, possibly, to brain connectivity.
Wireless Passive Stimulation of Engineered Cardiac Tissues (2017)

We present a battery-free radio frequency (RF) microwave activated wireless stimulator, 25 × 42 × 1.6 mm<sup>3</sup> on a flexible substrate, featuring high current delivery, up to 60 mA, to stimulate engineered cardiac tissues. An external antenna shines 2.4 GHz microwave, which is modulated by an inverted pulse to directly control the stimulating waveform, to the wireless passive stimulator. The stimulator is equipped with an on-board antenna, multistage diode multipliers, and a control transistor. Rat cardiomyocytes, seeded on electrically conductive gelatin-based hydrogels, demonstrate synchronous contractions and Ca<sup>2+</sup> transients immediately upon stimulation. Notably, the stimulator output voltage and current profiles match the tissue contraction frequency within 0.5-2 Hz. Overall, our results indicate the promising potential of the proposed wireless passive stimulator for cardiac stimulation and therapy by induction of precisely controlled and synchronous contractions.
Task-oriented representation of asynchronous user interfaces (1989)

A simple, task-oriented notation for describing user actions in asynchronous user interfaces is introduced. This User Action Notation (UAN) allows the easy association of actions with feedback and system state changes as part of a set of asynchronous interface design techniques, by avoiding the verbosity and potential vagueness of prose. Use within an actual design and implementation project showed the UAN to be expressive, concise, and highly readable because of its simplicity. The task- and user-oriented techniques are naturally asynchronous and a good match for object-oriented implementation. Levels of abstraction are readily applied to allow definition of primitive tasks for sharing and reusability and to allow hiding of details for chunking. The UAN provides a critical articulation point, bridging the gap between the task viewpoint of the behavioral domain and the event-driven nature of the object-oriented implementational domain. The potential for UAN task description analysis may address some of the difficulties in developing asynchronous interfaces.
Virtual artefacts to support negotiation within an augmented collaborative environment for alternate dispute resolution (2002)

Commercial organisations that are in dispute will sometimes seek to settle their differences without resorting to legal proceedings through a process of structured and facilitated negotiation called Alternate Dispute Resolution (ADR). Traditionally ADR negotiations are conducted by co-locating the mediator, witnesses, supporting evidence and representatives of each party. This paper describes a novel experiment that has been conducted at the University of Leeds to investigate whether an augmented collaborative environment could provide a realistic alternative to co-locating individuals for ADR negotiations. The individuals that took part in the experiment included an experienced mediator and practising legal representatives. The augmented collaborative environment was based on a video conferencing system that was enhanced to enable virtual artefacts representing items of evidence to be blended directly into the video streams. This experiment sits within the framework of the Court 21 Project, that is seeking to identify how new technology can be used to improve the different aspects of the legal system [10].
Cyclodextrin-based pharmaceuticals (2008)

Cyclodextrins, cyclic oligosacharides, are useful pharmaceutical excipients, which have attracted widespread attention. The ground for their popularity from a pharmaceutical point of view is in their ability to change undesirable characteristics of the drugs, such as unpleasant taste, low aqueous solubility, chemical instability and improving the drug bioavailability by inclusion complex formation. Due to their biocompatibility, cyclodextrins may be used in formulations indented for different routes of drug application including oral, ocular, nasal and even parenteral route. This article outlines the importance and functionality of cyclodextrin in different dosage forms and indicates the possible directions of future development.
Angular and Wavelength Simultaneous Selection in Transparent OPVs Based on Near-Infrared Bragg Reflector and Antireflection Coating (2016)

A novel design based on genetic algorithm is proposed to construct a near-infrared Bragg reflector and an antireflection coating, which are supposed to be applied in the transparent organic photovoltaics. By incorporating the absorbing layer which composed of ClAlPc/C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">60</sub> with the structure designed, it leads to a significant near-infrared absorption increase from 16.6% to 36.3% within 650-850 nm and high average visible-transparency of 72% within 400-580 nm at normal incidence. Moreover, the near-infrared absorption increases with the enlargement of the incident angle from 0° to 30°, where the average transmittance remains above 60% simultaneously. This design can further improve the balance between transparency in the visible for scenic sight view and sunlight absorption in near-infrared for high-efficiency electricity generation. The potential of adopting this novel design on transparent building-integrated photovoltaic modules, which dominate the landscape of the major cities, is tremendous.
Patents Relating to Chemistry: 211,016. and 212,017. Manufacture of white pigents (1879)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPatents Relating to Chemistry: 211,016. and 212,017. Manufacture of white pigentsH KnightCite this: J. Am. Chem. Soc. 1879, 1, 4, 123Publication Date (Print):April 1, 1879Publication History Published online9 January 2004Published inissue 1 April 1879https://pubs.acs.org/doi/10.1021/ja02144a647https://doi.org/10.1021/ja02144a647research-articleACS PublicationsRequest reuse permissionsArticle Views21Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas: association with degree of DNA aneuploidy. (1996)

Detailed information about intratumor K-ras2 mutations in colorectal adenocarcinomas and a possible association with DNA content heterogeneity is still lacking. DNA diploid and aneuploid subclones, detected among multiple histologically selected primary sectors (57 superficial and 40 deep) and 9 lymph node metastases, were flow cytometrically sorted and separately submitted to codons 12-13 K-ras2 mutation spectrum analysis. DNA aneuploidy was absent among 20 near and 20 distant mucosa sites and present in 7/9 lymph node metastases and in 17/19 primary tumors (90%). Primary intratumor DNA multiclonality was approximately 50%. Degree of DNA aneuploidy (DNA Index) distribution was nonrandom and showed peaks at approximate mean DNA Index values 1.2, 1.5, and 1.8. K-ras2 mutations were detected in 0/20 mucosa cases, in 2/9 lymph node metastases, and in 9/19 adenocarcinomas (47%). No more than one mutation type per tumor was detected. Intratumor distribution of K-ras2 mutations was homogeneous in 6 and heterogeneous in 3 cases. Homogeneous distribution was associated with DNA near-diploid aneuploidy. K-ras2 mutations were strongly associated with DNA Index in the near-diploid region (83%) and almost absent (5%) among DNA near-triploid subclones (P = 0.0001). K-ras2 mutation intratumor heterogeneity indicates that sampling of the tumor may be a critical step and suggests that K-ras2 activation may be a late event in a subgroup of tumors. Our data also suggest the existence of an early process of the colorectal carcinogenesis that favors both K-ras2 mutations and DNA near-diploid aneuploidy. Onset of DNA near-triploid subclones appears, instead, to be independent from K-ras2 activation.
Anti-GM1 antibodies in patients with Guillain-Barre syndrome. (1992)

Anti-GM1 antibodies were measured in 22 patients with the Guillain-Barré syndrome (GBS) and compared with anti-GM1 antibody activity in patients with other neurological or immunological diseases and in normal subjects. Four out of 22 patients with GBS had raised IgM, IgG, or IgA anti-GM1 antibody activities. All four patients were tetraparetic with only minimal or no sensory deficit. Three of the patients had highly raised antibody activity and showed severe residual deficits, while of the remaining patients with GBS, only one remained severely affected. One patient had anti-GM1 antibodies specific for GM1, whereas the other three patients showed antibody activity with asialo-GM1 or GD1b. The presence of anti-GM1 antibodies may define a subgroup of patients with GBS who have a poor prognosis.