gebhart/patrepeval huggingface dataset:
Joint Network Optimization and Downlink Beamforming for CoMP Transmissions Using Mixed Integer Conic Programming (2013)

Coordinated multipoint (CoMP) transmission is a promising technique to mitigate intercell interference and to increase system throughput in single-frequency reuse networks. Despite the remarkable benefits, the associated operational costs for exchanging user data and control information between multiple cooperating base stations (BSs) limit practical applications of CoMP processing. To facilitate wide usage of CoMP transmission, we consider in this paper the problem of joint network optimization and downlink beamforming (JNOB), with the objective to minimize the overall BS power consumption (including the operational costs of CoMP transmission) while guaranteeing the quality-of-service (QoS) requirements of the mobile stations (MSs). We address this problem using a mixed integer second-order cone program (MI-SOCP) framework and develop an extended MI-SOCP formulation that admits tighter continuous relaxations, which is essential for reducing the computational complexity of the branch-and-cut (BnC) method. Analytic studies of the MI-SOCP formulations are carried out. Based on the analyses, we introduce efficient customizing strategies to further speed up the BnC algorithm through generating tight lower bounds of the minimum total BS power consumptions. For practical applications, we develop polynomial-time inflation and deflation procedures to compute high-quality solutions of the JNOB problem. Numerical results show that the inflation and deflation procedures yield total BS power consumptions that are close to the lower bounds, e.g., exceeding the lower bounds by about 12.9% and 9.0%, respectively, for a network with 13 BSs and 25 MSs. Simulation results also show that minimizing the total BS power consumption results in sparse network topologies and reduced operational overhead in CoMP transmission and that some of the BSs are switched off when possible.
L1 RTK System with Fixed Ambiguity: What SBAS Ranging Brings (2007)

Given paper deals with centimeter level L1 RTK systems. L1 and L1&L2 RTK provide the same centimeter level accuracy for short baselines. However, unlike expensive L1/L2 RTK, with cheaper L1 RTK one cannot expect too fast (seconds) On-The-Fly (OTF) ambiguity resolution, which delivers cm accuracy. Known disadvantages of L1 RTK system (compared to L1&L2) are baseline length restriction (typically 10 km) and noticeable performance degradation under shaded sky. Augmented GPS constellation can mitigate these disadvantages. It is known that SBAS Satellites provide not only long/fast/ionosphere corrections. They are also a source of GPS-like signal which pseudo range and carrier phase measurements can be potentially used in positioning together with GPS measurements. Given paper proves that SBAS measurements can make a good job to augment GPS L1 RTK. We give a lot of real life collected statistic (with WAAS, EGNOS and in less degree MSAS) which demonstrate dramatic performance enhancement of L1 RTK thanks to using SBAS. The data used for validation were collected with Magellan ProMark3 and DG14 receivers supporting L1 GPS+SBAS RTK.
Monoclonal Antibodies That Recognize Trypsin Binding Domain of Human Urinary Trypsin Inhibitor (1993)

Three MAb M2, B6, P1 (IgG1 type) against human urinary trypsin inhibitor (UTI), a glycoprotein with antiinflammatory properties, have been produced by hybridization of mouse myeloma cells P3o1 with spleen cells of immunized mice BALB/c. Competitive ELISA-examination of peroxidase conjugates of M2, B6, and P1 MAb in the presence of the trypsin binding domain shows the highest affinity of M2 antibody for this domain. On the basis of MAb M2 competitive ELISA of UTI concentration in urine is proposed. ELISA detectable changes in the UTI content of urine from patients with nephritis without renal failure can be considered as an early index of renal parenchyma damage.
Ferroelectric‐Gated Two‐Dimensional‐Material‐Based Electron Devices (2017)

Two‐dimensional (2D) materials have the potential to extend state‐of‐the‐art semiconductor technology to sub‐nanometer scales and have inspired numerous research efforts exploring novel device structures. The key elements of electron devices, including low‐resistance contacts and reliable gate dielectrics, have to be optimized to complete a functional device. This review highlights recent studies on the integration of ferroelectrics with 2D materials to implement 2D electron devices. The high polarization field and ultra‐high dielectric constants of ferroelectric materials enable versatile carrier tuning in 2D materials. Various novel device structures and functionalities are enabled with the integration of ferroelectrics and 2D materials. Representative examples, including ferroelectric‐gated 2D memory devices, low‐power field‐effect transistors enabled by high‐ k ferroelectrics and negative capacitance effect, and optothermal and photoelectronic devices, are reviewed. Current developments and remaining challenges in ferroelectric‐gated 2D electron devices are discussed.
The Barrett’s Antigen Anterior Gradient-2 Silences the p53 Transcriptional Response to DNA Damage (2004)

The esophageal epithelium is subject to damage from bile acid reflux that promotes normal tissue injury resulting in the development of Barrett's epithelium. There is a selection pressure for mutating p53 in this preneoplastic epithelium, thus identifying a physiologically relevant model for discovering novel regulators of the p53 pathway. Proteomic technologies were used to identify such p53 regulatory factors by identifying proteins that were overexpressed in Barrett's epithelium. A very abundant polypeptide selectively expressed in Barrett's epithelium was identified as anterior gradient-2. Immunochemical methods confirmed that anterior gradient-2 is universally up-regulated in Barrett's epithelium, relative to normal squamous tissue derived from the same patient. Transfection of the anterior gradient-2 gene into cells enhances colony formation, similar to mutant oncogenic p53 encoded by the HIS175 allele, suggesting that anterior gradient-2 can function as a survival factor. Deletion of the C-terminal 10 amino acids of anterior gradient-2 neutralizes the colony enhancing activity of the gene, suggesting a key role for this domain in enhancing cell survival. Constitutive overexpression of anterior gradient-2 does not alter cell-cycle parameters in unstressed cells, suggesting that this gene is not directly modifying the cell cycle. However, cells overexpressing anterior gradient-2 attenuate p53 phosphorylation at both Ser(15) and Ser(392) and silence p53 transactivation function in ultraviolet (UV)-damaged cells. Deletion of the C-terminal 10 amino acids of anterior gradient-2 permits phosphorylation at Ser(15) in UV-damaged cells, suggesting that the C-terminal motif promoting colony survival also contributes to suppression of the Ser(15) kinase pathway. These data identify anterior gradient-2 as a novel survival factor whose study may shed light on cellular pathways that attenuate the tumor suppressor p53.
Improved Performance OFDM Exploiting Polarization (2006)

A new OFDM modulation technique exploiting polarization is presented. The proposed Alternating Dual Polar- ization Stages OFDM (APDS-OFDM) is comparable to conven- tional OFDM in terms of computational complexity. The main drawback of APDS-OFDM is the need for dual signal paths to implement the polarization. However, this OFDM technique offers the following improvements: Peak-to-average power is 3 dB lower per channel, less expensive frequency sources can be used, and the modulation is far less sensitive to inter-carrier interference (ICI) caused by Doppler. I. INTRODUCTION
High‐Capacity Silicon–Air Battery in Alkaline Solution (2011)

Elements with potential: A silicon–air battery using an alkaline solution as electrolyte is comprised of only environmentally friendly and widely available elements, including silicon, potassium, oxygen, and hydrogen. The assembled battery exhibits an average working potential between 0.9 to 1.2 V at variable discharge current densities, and high specific capacities are achieved.
Synthesis of conjugated copolymers containing phenothiazinylene vinylene moieties and their electrooptic properties (2003)

Abstract Four different types of conjugated copolymers, consisting of alternating structures of phenothiazinylene vinylene and phenylene vinylene derivatives such as phenylene vinylene, 1,1′‐biphenyl‐4,4′‐ylene vinylene, 2‐methoxy‐5‐(2‐ethylhexyloxy)‐1,4‐phenylene vinylene, and 9,10‐anthrylene vinylene, were prepared by Horner–Emmons condensation between appropriate diphosphonates and dialdehydes. Single‐layer and double‐layer light‐emitting diodes were fabricated with the synthesized conjugated polymers, and their electroluminescent properties were investigated. Poly( N ‐2‐ethylhexyl‐3,6‐phenothiazinylene vinylene‐ alt ‐9,10‐anthrylene vinylene), containing phenothiazinylene vinylene and anthrylene vinylene as repeat units, emitted a reddish‐orange color with Commission Internationale de l'Eclairage coordinates of x = 0.6173 and y = 0.3814 that was very similar to the National Television System Committee standard red, and it showed a bipolar carrier‐injection/transporting capability caused by electron‐withdrawing anthracene and electron‐donating amino groups. Poly[ N ‐2‐ethylhexyl‐3,6‐phenothiazinylene vinylene‐ alt ‐2‐methoxy‐5‐(2‐ethylhexyloxy)‐1,4‐phenylene vinylene], containing phenothiazinylene vinylene and dialkoxy phenylene vinylene moieties, showed excellent hole‐injection/transporting capability. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 2502–2511, 2003
SU‐GG‐I‐91: An Automatic Contouring Method That Combines Rule‐Based, Atlas‐Based, and Mesh‐Based Approaches (2008)

Purpose: Image segmentation technology can automate the task of contouring organs at risk for radiation treatment planning. While automatic methods tend to be rule‐based, atlas‐based, or mesh‐based, a combination of all three approaches is proposed. Method and Materials: Model‐based segmentation can be initialized by automatically positioning the adaptable meshes relative to the scan. The entire scene is segmented in order to recognize the approximate organ locations. Segmentation is accomplished by a 5‐layer hierarchy that propagates information from the voxel layer up to voxel neighborhoods, then tissues, then organs, and finally organ systems. The voxel layer treats each voxel as an independent statistical event. Bayesian classification uses an atlas in the form of a spatially varying prior constructed from training data. The classification is adaptive within an Expectation‐Maximization framework that iteratively performs segmentation and model‐estimation simultaneously. The neighborhood layer introduces local contextual constraints using Markov random fields. The tissue layer corrects mistakes using a series of logical rules. The organ layer divides tissue into different organs, or stitches different tissues together to form an organ. Organ cross‐sections are segmented in order by quantitative confidence measures. The systems layer manipulates geometric primitives that have been fit to organs in order to reconcile overlaps. Results: The automatic initialization of meshes has been trained and tested on 5 prostatic datasets. Processing time for volumes with roughly 60 slices, and 256×256 pixels per slice, is 40 seconds on a standard PC, without any human interaction. The segmentation results from the same 5‐layer hierarchy were verified by the trained experts and redeemed to be acceptable. Conclusion: A 5‐layer hierarchy can perform both recognition and delineation, seeing the big picture as well as the details. Such a framework where local decisions are supported by global properties can be useful in addressing inconsistent rectum contents.
The MYD88-Independent Pathway Is Not Mobilized in Human Neutrophils Stimulated via TLR4 (2007)

LPS activates both MyD88-dependent and -independent signaling via TLR4, but the extent to which each cascade is operative in different cell types remains unclear. This prompted us to revisit the intriguing issue of CXCL10 production, which we previously showed to be inducible in neutrophils stimulated with LPS and IFN-gamma but not with either stimulus alone, contrary to other myeloid cells. We now report that in neutrophils the MyD88-independent pathway is not activated by LPS. Indeed, microarray and real-time PCR experiments showed that neither IFNbeta nor IFNbeta-dependent genes (including CXCL10) are inducible in LPS-treated neutrophils, in contrast to monocytes. Further investigation into the inability of LPS to promote IFNbeta expression in neutrophils revealed that the transcription factors regulating the IFNbeta enhanceosome, such as IFN-regulatory factor-3 and AP-1, are not activated in LPS-treated neutrophils as revealed by lack of dimerization, nuclear translocation, confocal microscopy, and inducible binding to DNA. Moreover, we show that the upstream TANK-binding kinase-1 is not activated by LPS in neutrophils. A lack of IFNbeta/CXCL10 mRNA expression and IFN-regulatory factor 3 activation was also observed in myeloid leukemia HL60 cells differentiated to granulocytes and then stimulated with LPS, indicating that the inability of neutrophils to activate the MyD88-independent pathway represents a feature of their terminal maturation. These results identify a disconnected activation of the two signaling pathways downstream of TLR4 in key cellular components of the inflammatory and immune responses and help us to better understand the primordial role of neutrophils in host defense against nonviral infections.
Alternate Pathway for Isoleucine Biosynthesis in <i>Escherichia coli</i> (1972)

A threonine dehydrataseless mutant of Escherichia coli, Crookes strain, was observed to grow on an acetate minimal medium without the usual requirement for isoleucine supplementation. Both the wild-type Crookes strain and a threonine auxotroph metabolized l-glutamate-1-(14)C to l-isoleucine-1-(14)C with no appreciable randomization, suggesting that a pathway for isoleucine formation from glutamate via beta-methylaspartate, beta-methyloxaloacetate, and alpha-ketobutyrate was possible in addition to the pathway from threonine and alpha-ketobutyrate. Crude cell-free extracts formed (14)C-beta-methylaspartate from (14)C-glutamate, and the conversion of beta-methylaspartate to alpha-ketobutyrate was also demonstrated, thus supporting the conclusion that glutamate can serve as a precursor of alpha-ketobutyrate (and isoleucine) without the necessary involvement of threonine as an intermediate.
Monoclonal antibodies to the pituitary growth-hormone receptor by the anti-idiotypic approach. Production and initial characterization (1990)

We obtained 10/192 and 3/384 antibody-secreting hybrids after immunization of Balb/c mice with either human growth hormone or affinity-purified rabbit anti-(human growth hormone) respectively. Radiolabelled rabbit anti-(human growth hormone) antibodies, but not human growth hormone, were specifically bound by supernatants from the 13 hybrids. The binding was completely inhibited by human-growth-hormone serum binding protein. However, anti-(human growth hormone antibodies) were detected in the sera of all the mice immunized with human growth hormone. In an independent fusion, which was carried out after immunization with fewer doses of human growth hormone, anti-(human growth hormone) antibodies were also obtained. Five hybrids, where the starting antigen was human growth hormone, were selected for ascites production, and the corresponding monoclonal antibodies were partially purified and characterized with respect to their immunoglobulin isotype and their interaction with human-growth-hormone receptors. These antibodies were found to enhance the binding of radioiodinated human growth hormone to human-growth-hormone serum binding protein from human and rabbit plasma by 40%. Scatchard analysis of the effect of one of the monoclonal antibodies showed that this enhancement was due to an increased number of binding sites. All of the partially purified antibodies but one (F12) inhibited the binding of human growth hormone to rat but not rabbit, liver microsomes to various extents, as well as to H-4-II-E rat hepatoma cells. Monoclonal antibody F12 enhanced the binding of radiolabelled human growth hormone to rat liver microsomes and H-4-II-E hepatoma cells. This enhancement was found to be due to an increase in the number of binding sites.
Optical Parametric Chirped Pulse Amplification at High Repetition Rate Free Electron Laser Facility (2012)

The development of a high repetition rate Optical Parametric Chirped-Pulse Amplifier (OPCPA) system is presented. The main objective of this development is to harness the OPCPA technique for applications at a free-electron laser facility.
DomainKeys Identified Mail (DKIM) and Mailing Lists (2011)

DomainKeys Identified Mail (DKIM) allows an administrative mail domain
(ADMD) to assume some responsibility for a message. Based on
deployment experience with DKIM, this document provides guidance for
the use of DKIM with scenarios that include Mailing List Managers
(MLMs).
American Ginseng Improves Glycemia in Individuals with Normal Glucose Tolerance: Effect of Dose and Time Escalation (2000)

In nondiabetic individuals, 3, 6 or 9 g of AG taken 40, 80 or 120 minutes before a glucose challenge similarly improved glucose tolerance.
Decentralized Netting Protocol over Consortium Blockchain (2018)

In recent years, Bitcoin, Ethereum and other cryptocurrencies have attracted a great deal of attention from the whole industry including the financial as a new settlement system. Transaction information of these cryptocurrencies is stored in a distribution ledger called Blockchain on the P2P network through processing such as PoW. Meanwhile, since PoW requires a large amount of computer resources, researches on private / consortium type blockchain that do not need PoW. In this paper, we propose a decentralized netting protocol using a consortium type block chain that has the channel function. On a system that implements the proposed protocol, netting settlement can be performed on P2P hiding information of the sender and receiver name of transaction, amount of money, calculation butt of netting, and without setting up a specific central organization such as a central server.
Impact of RSV: implications for managed care. (2009)

Severe RSV disease, manifested as bronchiolitis or pneumonia, is the leading cause of hospitalization of infants younger than 1 year of age in the United States. Infants born 35 weeks or less GA are particularly at high risk of severe RSV disease, which may result in frequent NICU admissions or long hospital stays and additional health care utilization over the first 12 months of life. This care is costly--infants 33 to 36 weeks GA with a history of RSV hospitalization incur costs that are nearly 5 times as much as costs for 33 to 36 weeks GA infants with no history of RSV hospitalization. Managed care payers should be cognizant of the potential ramifications of severe RSV disease in infants. Developing a proactive RSV management strategy can help improve health outcomes and reduce unnecessary hospital resource use.
A high throughput array microscope for the mechanical characterization of biomaterials (2015)

In the last decade, the emergence of high throughput screening has enabled the development of novel drug therapies and elucidated many complex cellular processes. Concurrently, the mechanobiology community has developed tools and methods to show that the dysregulation of biophysical properties and the biochemical mechanisms controlling those properties contribute significantly to many human diseases. Despite these advances, a complete understanding of the connection between biomechanics and disease will require advances in instrumentation that enable parallelized, high throughput assays capable of probing complex signaling pathways, studying biology in physiologically relevant conditions, and capturing specimen and mechanical heterogeneity. Traditional biophysical instruments are unable to meet this need. To address the challenge of large-scale, parallelized biophysical measurements, we have developed an automated array high-throughput microscope system that utilizes passive microbead diffusion to characterize mechanical properties of biomaterials. The instrument is capable of acquiring data on twelve-channels simultaneously, where each channel in the system can independently drive two-channel fluorescence imaging at up to 50 frames per second. We employ this system to measure the concentration-dependent apparent viscosity of hyaluronan, an essential polymer found in connective tissue and whose expression has been implicated in cancer progression.
Reduction of cellular energy requirements (1988)

Protection of the brain and spinal cord against ischemia is a goal of vast clinical importance. One approach to this objective is to reduce the tissue's functional activity in order to preserve energy for the metabolic processes that are essential to viability. Experiments to explore ways of reducing function-related energy demands were performed on isolated rabbit retina, a well-characterized model of organized adult mammalian central nervous system (CNS) tissue. The retina was maintained in a nearly physiological state in a miniature "heart-lung" apparatus. Energy metabolism (oxygen consumption and glycolysis) and electrophysiological function (determined by electroretinogram) of the in vitro retina were monitored, and their responses to a series of agents that may reduce energy requirements were determined. Large reversible reductions in O2 consumption, glycolysis, and electrophysiological function were seen in response to mild hypothermia (-3 degrees to -6 degrees C), phenytoin (Dilantin, 100 to 200 mg/kg), chlordiazepoxide (Librium, 200 microM), lithium (1 to 4 mM), Mg++ (6 to 20 mM), strophanthidin (0.15 to 0.25 microM), CO2 (25% to 30%), 2-amino-5-phosphonovaleric acid (APV, 500 microM), amiloride (1 mM), and dantrolene (1 mM). One retina was exposed simultaneously to a combination of six of these agents, which reduced its oxidative and glycolytic metabolism to less than 50% of the control level. The retina recovered metabolic and electrophysiological function after a 2 1/2-hour exposure period. Other agents tested (diphenhydramine, midazolam, nifedipine, nimodipine, and quercetin) had effects on energy metabolism and electrophysiological function that were poorly reversible. Surprisingly little effect was seen in response to general anesthetic agents (thiopental and Althesin) and other CNS depressants (chlorpromazine, ethanol, lidocaine, paraldehyde, valproic acid, and baclofen). The presumed mechanisms through which these agents reduce cellular energy requirements, as well as their potential roles in the treatment of CNS ischemia, are discussed.
Religión, fiestas, mitos y ritos mazatecos (1998)

El mazateco es uno de los 56 grupos étnicos mayoritarios de la República Mexicana, Habita la zona noreste del estado de Oaxaca y parte de los estados de Puebla y Veracruz. Su territorio forma parte de la cuenca del Papaloapan, que ocupa una porción de los estados de Puebla y Veracruz. Su territorio forma parte de la cuenca del Papaloapan, que ocupa una porción de los estados antes citados. La cuenca está formada por tierras altas y montañosas en los estados de Oaxaca y Puebla, que se abren hacia la llanura veracruzana hasta llegar al mar. El territorio mazateco se divide en dos regiones plenamente distintas, que son Mazateca Alta y la Mazateca Baja. La Mazateca Alta es lo que comprende la parte alta de la Sierra Madre Oriental y la Mazateca Baja es lo que ocupa la presa Presidente Alemán.