gebhart/patrepeval huggingface dataset:
Serum factors that regulate phagocytosis of liposomes by Kupffer cells (1993)

Conference Article| May 01 1993 Serum factors that regulate phagocytosis of liposomes by Kupffer cells S. Moein Moghimi; S. Moein Moghimi * Search for other works by this author on: This Site PubMed Google Scholar Harish M. Patel Harish M. Patel 1Department of Biochemistry, Charing Cross Hospital Medical School, Fulham Palace Road, London W6 8RF, England Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1993) 21 (2): 128S. https://doi.org/10.1042/bst021128s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation S. Moein Moghimi, Harish M. Patel; Serum factors that regulate phagocytosis of liposomes by Kupffer cells. Biochem Soc Trans 1 May 1993; 21 (2): 128S. doi: https://doi.org/10.1042/bst021128s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1993 Biochemical Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
The visualization simulation platform design of low-voltage power line carrier communication system (2011)

There are three steps to establish the visualization simulation platform of low-voltage power line carrier communication system. Firstly, we establish the MARLAB/Simulink simulation platform to simulate low-voltage power line carrier communication system. The simulation platform bases on the analysis of power line channel characteristics and take the multipath channel transmission model of M.Zimmermann and K.Dostert. Then, we actually measure a large of noise, and the collected data of noise is made of MAT file. We use the SIMULINK's From File model to set up the noise simulation model based on the analysis of noise characteristics. Lastly, through the parameters of channel and simulation are inputted in the designing GUI interface in order to control the process of system simulation, we realize the visualization of system simulation based on the object-oriented thought. Based on setting up the platform, it is proof that using the adaptive OFDM technology can overcome the frequency-selective fading characteristics of power line channel transmission, enhance the system's anti-interference capability and realize the reliable high-speed data communication.
On Formalism in Specifications (1985)

A critique of a natural-language specification, followed by presentation of a mathematical alternative, demonstrates the weakness of natural language and the strength of formalism in requirements specifications.
Comparison of Lactoperoxidase- and Thyroid Peroxidase-Catalyzed Iodination and Coupling* (1974)

Thyroid peroxidase (TPO) and lactoperoxidase (LPO) were compared with respect to their ability to catalyze protein iodination and T4 formation. Goiter thyroglobulin was used as the protein acceptor in most cases, since thyroglobulin is most likely the physiological substrate for peroxidase in the thyroid gland. Experiments were also performed with BSA, fibrinogen and casein. With goiter thyroglobulin as the protein acceptor LPO and TPO were about equally active in catalyzing T4 formation at pH 7.0. At pH 7.0 LPO was also as effective as TPO in catalyzing the conversion of DIT to T4 (coupling reaction). Iodinations were performed with concentrations of iodide varying from 10 µM to 10 mM. With both TPO and LPO, inhibition of iodination was observed when the concentration of I− exceeded 1 mM. Attempts to calculate Km (I−) for LPO were complicated by marked deviation of Lineweaver-Burk plots from linearity. However, the results indicated that at pH 7.0 TPO was more effective than LPO at concentrations of iodide approaching the physiological range (10–40 µM). In this respect TPO appears to be better adapted for thyroid function than LPO. However, at concentrations of I− near 1 mM, LPO became nearly as effective or more effective than TPO. With goiter thyroglobulin as acceptor the maximally observed moles of I bound per mole of enzyme per min were 8.2 Ô 103 for LPO and 6.3 Ô 103 for TPO. The pH optimum for TPO-catalyzed iodination (6.6–7.0) was closer to the physiological range than that for LPO-catalyzed iodination (¼ 6.0). From the results of this study we conclude that TPO possesses no marked specificity in its ability to catalyze iodination and T4 formation. (Endocrinology94: 1286, 197)
Preparation of Benzyl and p-Nitrobenzyl Esters of Amino Acids<sup>1</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of Benzyl and p-Nitrobenzyl Esters of Amino Acids1JAMES E. SHIELDS, WILLIAM H. McGREGOR, and FREDERICK H. CARPENTERCite this: J. Org. Chem. 1961, 26, 5, 1491–1494Publication Date (Print):May 1, 1961Publication History Published online1 May 2002Published inissue 1 May 1961https://pubs.acs.org/doi/10.1021/jo01064a043https://doi.org/10.1021/jo01064a043research-articleACS PublicationsRequest reuse permissionsArticle Views750Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Strand‐loop‐strand motifs: Prediction of hairpins and diverging turns in proteins (2003)

Beta-sheet proteins have been particularly challenging for de novo structure prediction methods, which tend to pair adjacent beta-strands into beta-hairpins and produce overly local topologies. To remedy this problem and facilitate de novo prediction of beta-sheet protein structures, we have developed a neural network that classifies strand-loop-strand motifs by local hairpins and nonlocal diverging turns by using the amino acid sequence as input. The neural network is trained with a representative subset of the Protein Data Bank and achieves a prediction accuracy of 75.9 +/- 4.4% compared to a baseline prediction rate of 59.1%. Hairpins are predicted with an accuracy of 77.3 +/- 6.1%, diverging turns with an accuracy of 73.9 +/- 6.0%. Incorporation of the beta-hairpin/diverging turn classification into the ROSETTA de novo structure prediction method led to higher contact order models and somewhat improved tertiary structure predictions for a test set of 11 all-beta-proteins and 3 alphabeta-proteins. The beta-hairpin/diverging turn classification from amino acid sequences is available online for academic use (Meiler and Kuhn, 2003; www.jens-meiler.de/turnpred.html).
Serotonergic hallucinogens as translational models relevant to schizophrenia (2013)

One of the oldest models of schizophrenia is based on the effects of serotonergic hallucinogens such as mescaline, psilocybin, and (+)-lysergic acid diethylamide (LSD), which act through the serotonin 5-HT(2A) receptor. These compounds produce a 'model psychosis' in normal individuals that resembles at least some of the positive symptoms of schizophrenia. Based on these similarities, and because evidence has emerged that the serotonergic system plays a role in the pathogenesis of schizophrenia in some patients, animal models relevant to schizophrenia have been developed based on hallucinogen effects. Here we review the behavioural effects of hallucinogens in four of those models, the receptor and neurochemical mechanisms for the effects and their translational relevance. Despite the difficulty of modelling hallucinogen effects in nonverbal species, animal models of schizophrenia based on hallucinogens have yielded important insights into the linkage between 5-HT and schizophrenia and have helped to identify receptor targets and interactions that could be exploited in the development of new therapeutic agents.
Measurement of High-NA Axisymmetric Aspherical Surface with Continuous Interference Method (2008)

The measurement principle where in a high-NA (Numerical Aperture) surface, for which the degree of the angle of surface inclination exceeds π/3 radians, could be evaluated with high precision and high speed is proposed. This is based on the stitching method, where aspherical surface measurement becomes possible by dividing the surface of the sample into a range so that measurements can be made with an interferometer and finally combined. We examine the method of applying an interferometer to the condition in which the sample is rotated on an air spindle at a constant speed. It is not necessary in this method to make the sample static. Therefore, the vibration of the servo motor and any location errors can be eliminated. Moreover, the measurement time does not depend on the number of divided areas which are necessary for the stitching method, allowing for high-speed measurement. The principle behind this technique is expanded first, and an experiment system based on it was constructed. The principle proposed was evaluated, and its effectiveness was confirmed.
Reduction of Acrolein by Elemental Iron:  Kinetics, pH Effect, and Detoxification (2006)

Acrolein is a highly toxic alpha,beta-unsaturated aldehyde that is widely used as a biocide, a cross-linking agent, and an intermediate in the chemical industry, among other applications. In this study we investigated the reductive transformation of acrolein by elemental iron and evaluated the feasibility of using iron to detoxify acrolein. At acidic and neutral pH, acrolein was transformed by iron through reduction of the C=C double bond to propionaldehyde. The reduction appeared to involve the chemisorption of acrolein to the iron surface followed by reduction of adsorbed acrolein. Both the adsorption and reduction rate constants decreased with increasing pH. Between pH 7.0 and 7.4, the acrolein adsorption rate constant decreased precipitously, resulting in a sharp decline in its removal rate. At higher pH, acrolein disappeared rapidly in control without iron, presumably due to reversible, base-catalyzed hydration. At equilibrium, approximately 93% of acrolein was hydrated, corresponding to an equilibrium constant of 13. Acrolein at 25 mg/L completely inhibited aerobic respiration; in contrast, its reduction product propionaldehyde was biodegradable. This suggests that elemental iron may be used to pretreat acrolein-containing wastes prior to aerobic biodegradation. To our knowledge, this is the first report of reduction and detoxification of an alpha,beta-unsaturated aldehyde by elemental iron.
A "best strategy" (1997)

Researchers debate what is the best way for “clinical trialists” to develop and test “effective therapies” against HIV (below, 1 week’s supply of pills for a patient). And, in disagreement with earlier letters, a reader states that Nobel winners deserve to keep “every single cent” of their $1-million prize.
Third-generation TDRSS-compatible direct-sequence spread-spectrum digital receiver (1997)

A digital communication receiver, called a third-generation receiver, has been developed. This receiver takes samples of the direct-sequence spread signal at a nonzero intermediate frequency (IF) instead of the zero IF (baseband), and quantizes the samples by employing a 1-b analog-to-digital (A/D) converter at the receiver front end. These 1-b samples are digitally processed for pseudonoise (PN) code, carrier, bit synchronization, and bit decision with the use of an application-specific integrated circuit. The effects of the IF sampling and 1-b A/D conversion on PN code synchronization are analyzed for a PN spread-spectrum communication system with oversampling rate, e.g., 12 samples per chip. In addition, the bit-error rate (BER) degradation due to the 1-b A/D conversion is studied by assuming perfect PN code, carrier, and bit synchronization. It is observed that the BER degradation due to the 1-b A/D is significant, e.g., 2.4 dB, when decimation is made after IF sampling such that only one sample per chip is used for bit decision. These analyzed BER results agree well with the simulated results. However, if no decimation is made and oversampling is used for bit decision, BER degradation due to 2-b A/D conversion is insignificant, e.g., 0.6 dB.
Using causal reasoning to validate stochastic models (2002)

An important problem of validating stochastic models is addressed. Validating stochastic models is necessary for modeling high-performance and highly dependable computers accurately. This paper develops a model validation methodology using causal reasoning. More specifically, this technique uses the structural and behavioral knowledge derived from the system specification and a causal reasoning mechanism for validation purposes. The scope of this research is limited to the conceptual validation of Markov models. Conceptual validation, as opposed to empirical validation, does not require the use of data. The validation process primarily involves generating a reference object, translating the given model into a common format, and comparing the two objects to identify holes and inconsistencies. Event trees are used as the common format. The effectiveness of this methodology is tested by validating models of five example systems. For testing purposes, errors are introduced into the models of these systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An in vitro study on effect of Delmopinol application on Candida albicans adherence on heat cured denture base acrylic resin: A thorough study (2013)

Heat-cured acrylic resin shows greater reduction in adherence of Candida albicans by contamination after Delmopinol application as compared with contamination before Delmopinol application.
Assessing the business impact of location based services (2004)

Location based services are a growth area for service providers looking to fulfil new customer needs, and network operators looking to augment their revenues. While the idea of using information about customer location to deliver focused services may be extremely appealing, there are significant risks and challenges to be faced. In addition to the technical hurdles, understanding and catering to customer experience is critical for success. In this paper, we describe developments in the area of LBS, and propose a model to address customer experience issues in this domain. In particular, we describe the types of revenue models and niche applications that might be profitably targeted by LBS providers.
An intelligent high dynamic range video codec for handheld devices (2011)

This paper presents a system that improves the viewing quality of video broadcast on current commercially available mobile display devices. Existing coding standards are used to transmit High Dynamic Range video and ambient lighting data is used to enhance the image displayed. The system remains fully backward compatible.
Information processing in spectroscopy (1989)

In all spectroscopic methods, there exists an integral equation relating the observed spectrum and the intensity distribution observed by the spectroscopic instrument. An improved spectrum can be reconstructed by solving this integral equation. A process of eigenvalue analysis based on the theory of Hilbert and Schmidt was developed and applied to solve the equation. Formulation of this method and some computer simulations are presented on the results from a Fabry-Perot interferometer, a diffraction grating, and a two-beam interferometer. We also apply this method to spectroscopic techniques and considerations of resolution.
Empirical findings relating sample volume size to diagnostic accuracy in pulsed doppler cerebrovascular studies (1982)

Ultrasonic duplex scanning has a sensitivity of 97% in detecting disease of the carotid bulb. However, the specificity is much less, being 37%. The error in distinguishing normal arteries from those with minimal disease appears to be in part related to the size of the sample volume of the pulsed Doppler. This paper addresses the importance of the features of scan head design in relation to distinguishing normal and diseased arteries.
Induced accelerated autocondensation of polyflavonoid tannins for phenolic polycondensates. I. <sup>13</sup>C‐NMR, <sup>29</sup>Si‐NMR, X‐ray, and polarimetry studies and mechanism (1994)

Abstract Polyflavonoid tannins have been found to autocondense and harden when in presence of small amounts of SiO 2 at high pH. Small amounts of boric acid and AICI 3 were found to have the same effect. The mechanism of tannin autocondensation to hardening was found to depend on the Lewis acid behaviour of the additives used. Such mechanism involves Lewis acid acceptance of electrons from the ether oxygen of the flavonoid unit pyran ring with subsequent facilitation of base‐induced heterocycle opening. The reactive C2 site created by heterocycle opening proceeds to autocondense with the reactive A‐ring of a flavonoid unit on another chain denying to the flavonoid the possibility of intramolecular rearrangements to catechinic acid and phlobatannin which occur in model compounds. Si has been shown to pass through a coordination state of 5, by CP‐MAS 29 Si‐NMR. The portion of Si, which has not been able to complete the reaction due to premature hardening, remains attached to the flavonoids, in this coordination state, in the hardened network. The Si portion, which has completed the reaction and caused the hardening, reverts instead to SiO 2 and is detached from the flavonoid. The SiO 2 , H 3 BO 3 , and AICI 3 mechanism shows that their presence also reverses the relative facility of cleavage between interflavonoid bond and heterocycle opening in mainly procyanidin and profisetinidin tannins. © 1994 John Wiley & Sons, Inc.
Structure-Activity Relationship of Anthelmintic Cyclooctadepsipeptides (2011)

The relationship between cyclooctadepsipeptides and their anthelmintic efficacy was examined by converting the natural products, PF1022A, PF1022E and PF1022H. Some analogues substituted at the para position of the phenyllactate moiety showed higher or equivalent activity against the parasitic nematode, Ascaridia galli in chicken when compared with the parent compounds. It is suggested that lipophilicity and the polar surface area, in addition to structural requirements of the derivatives, influenced the anthelmintic efficacy in vivo.
The Role of Omega-3 Polyunsaturated Fatty Acids in Heart Failure: A Meta-Analysis of Randomised Controlled Trials (2016)

Many new clinical trials about the effect of omega-3 polyunsaturated fatty acids (PUFAs) in heart failure (HF) patients have shown inconsistent results. Therefore, a meta-analysis of randomised controlled trials (RCTs) was performed to determine the benefits of omega-3 PUFAs in HF patients. Articles were obtained from PubMed, EMBASE, and the Cochrane Library. RCTs comparing omega-3 PUFAs with placebo for HF were included. Two reviewers independently extracted the data from the selected publications. The <i>I</i>² statistic was used to assess heterogeneity. The pooled mean difference and associated 95% confidence intervals were calculated, and a fixed or random-effects model was used for the meta-analysis. A total of nine RCTs involving 800 patients were eligible for inclusion. Compared with patients taking placebo, HF patients who received omega-3 PUFAs experienced decreased brain natriuretic peptide levels and serum norepinephrine levels. Although the left ventricular ejection fraction (LVEF) and clinical outcomes (Tei index, peak oxygen consumption) did not improve, subgroup analysis showed that the LVEF increased in dilated cardiomyopathy (DCM) patients. Overall, omega-3 PUFA supplements might be beneficial in HF patients, especially in DCM patients, but further studies are needed to confirm these benefits.
Relationships between hydrogen ion, hydroxyl ion and salt concentrations and the growth of seven soil molds (1923)

Comparatively few data have been recorded relative to the effect of hydrogen ion concentration on the development and activities of molds and other fungi, altho such records have been secured for the bacteria. For both groups much more work has been accomplished on the effect of titratable acidity. The importance of molds in transforming plant food in the soil has made advisable the securing of such data. The present paper records the results of a study of the limiting and optimum hydrogen and hydroxyl ion concentrations and the limiting concentrations of several salts as related to the growth of seven different molds isolated from the soil.
Functional Morphing for Manufacturing Process Design, Evaluation and Control. (2010)

Shape changes are commonly identified in product development and manufacturing. These changes include part shape changes in a product family from one generation to another, surface geometric changes due to manufacturing operations, etc. Morphing is one method to mathematically model these shape changes. However, conventional morphing focuses only on geometric change without consideration of process mechanics/physics. It thus has limitations in representing a complex physical process involved in product development and manufacturing. This dissertation proposes a functional morphing methodology which integrates physical properties and feasibilities into geometric morphing to describe complex manufacturing processes and applies it to manufacturing process design, evaluation, and control. Three research topics are conducted in this dissertation in areas of manufacturing process design, evaluation and control. These are: • Development of evolutionary stamping die face morphing: Similarities which are identified among parts of the same product family allow the possibilities for the knowledge learned from the die design of one generation of sheet metal product to be morphed onto that of a new but similar product. A new concept for evolutionary die design is proposed using a functional morphing algorithm. Case studies show that the proposed method is able to capture the added features in the new part design as well as the springback compensation inherited from the existing die face. • Formability assessment in die face morphing: A strain increment method is proposed for early formability assessment by predicting strain distribution directly from the part-to-part mapping process based on the functional morphing algorithm. Since this method does not require the knowledge on the new die surface, such formability assessment can serve as an early manufacturing feasibility analysis on the new part design. • Functional morphing in monitoring and control of multi-stage manufacturing processes: A functional free form deformation (FFD) approach is developed to extract mapping functions between manufacturing stages. The obtained mapping functions enable multi-scale variation propagation analysis and intermediate-stage process monitoring. It also allows for accurate inter-stage adjustment that introduces shape deformation upstream to compensate for the errors downstream.
The nest biology of the bee Andrena (Ptilandrena) erigeniae Robertson (Hymenoptera: Andrenidae) (1975)

Detailed biological information on bees of the genus Andrena has been scarce (Linsley, MacSvvain, & Smith 1952b