gebhart/patrepeval huggingface dataset:
An Integrated Microrobotic Platform for On‐Demand, Targeted Therapeutic Interventions (2013)

The presented microrobotic platform combines together the advantages of self-folding NIR light sensitive polymer bilayers, magnetic alginate microbeads, and a 3D manipulation system, to propose a solution for targeted, on-demand drug and cell delivery. First feasibility studies are presented together with the potential of the full design.
Integrated dc SQUID magnetometer with a high slew rate (1984)

We have fabricated a magnetometer in which the thin-film superconducting pick-up loop and dc SQUID are integrated on a single silicon chip. The magnetometer, which is intended primarily for geophysical applications, has a magnetic field sensitivity of typically 5×10−15 T Hz−1/2 at frequencies above about 10 Hz, and 2×10−14/( f /1 Hz)1/2 T Hz−1/2 at lower frequencies. The dynamic range is ±2×107 Hz1/2 and the maximum slew rate is about 4×10−3 T s−1 at 6 kHz. This high slew rate enables the magnetometer to be operated in a flux-locked loop for long periods of time without losing lock.
Detection of Hydrophobic End Groups on Polymer Surfaces by Sum-Frequency Generation Vibrational Spectroscopy (2000)

We report the successful application of SFG to detect segregation of end groups on polymer surfaces. Two groups of polymer samples are studied: one is polyurethane with different surface-modified end groups, the other is poly(ethylene glycol) (PEG) with different end groups. For each group of polymers, both hydrophobic and hydrophilic end groups are chosen. With the surface sensitivity of SFG, we have found that hydrophobic end groups [e.g., methoxy on PEG or poly(dimethylsiloxane) (PDMS) on polyurethane] tend to segregate to the polymer surface in air. However, the hydrophilic end groups (e.g., hydroxyl group on PEG or PEG on polyurethane) remain in the bulk so that the surfaces that are exposed to air are covered by the polymer backbones. Although contact-angle measurements and XPS results can demonstrate that polymer surfaces indeed have been modified by different end groups, only SFG can show the surface structure at the molecular level.
Different Vagal Modulation of the Sinoatrial Node and AV Node in Patients with Congestive Heart Failure (1996)

1. We have previously shown that in healthy young men autonomic control of the sinoatrial (SA) and AV node may be independent during sleep. It is conceivable, that this independence is lost in patients with high sympathetic activity. This would be in analogy to exercise in normal subjects, where an increase in sinus rate is associated with a shortening of the PR interval. 2. The aim of this study was to investigate whether this independence of SA and AV nodal autonomic modulation is maintained in patients with congestive heart failure. 3. For analysis of heart rate variability (HRV) the ECG was online digitized from 10 pm to 6 am in six patients with congestive heart failure (EF < 40%). The onset of P-waves and QRS-complexes was recognized by a computer algorithm with an accuracy of +/-1 ms. Power spectra of PR intervals and PP intervals were calculated for consecutive 256 second segments. The power in the high frequency component. (HF, 0.15 - 0.4 Hz) of PP intervals was used as an index of vagal drive to the SA node. The vagal input to the AV node was determined by the spectral power of the corresponding PR intervals. 4. All patients showed the typical spectral peak in the HF band, both in PP and PR. The power spectral density of HF varied over time with different patterns for PP and PR. The ratio of the HF power derived from PP and PR was calculated for each segment. This ratio was not constant, but showed a distinct time course. 5. Congestive heart failure did not abolish the independence of vagal modulation of SA and AV node, as assessed by the HF power derived from PP and PR intervals. Thus, the difference in vagal traffic to the SA and AV node was maintained even in the setting of high background sympathetic activity. Further investigation is needed to analyze potential factors responsible for this difference in patterns and the clinical relevance of this finding.
Automatically Detecting Failures in Natural Language Processing Tools for Online Community Text (2015)

We illustrate the challenges of processing patient-generated online health community text and characterize failures of NLP tools on this patient-generated health text, demonstrating the feasibility of our low-cost approach to automatically detect those failures. Our approach shows the potential for scalable and effective solutions to automatically assess the constantly evolving NLP tools and source vocabularies to process patient-generated text.
Desorption ionization mass spectrometry: sample preparation for secondary ion mass spectrometry, laser desorption, and field desorption (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesorption ionization mass spectrometry: sample preparation for secondary ion mass spectrometry, laser desorption, and field desorptionK. L. Busch, S. E. Unger, A. Vincze, R. G. Cooks, and T. KeoughCite this: J. Am. Chem. Soc. 1982, 104, 6, 1507–1511Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/ja00370a009https://doi.org/10.1021/ja00370a009research-articleACS PublicationsRequest reuse permissionsArticle Views300Altmetric-Citations96LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<title>Imaging the stars: two approaches to the development of a holographic star chart</title> (1996)

Traditional star charts have several major problems that prevent them from reaching their full potential as educational tools. These include, most notably, opacity and the parallax problem,the solutions of which would make possible a more useful optical device that would permit the viewing of both the real stars and a projected image of the stars at infinity, with instructive labels, simultaneously and superimposed. A holographic star chart is such a device. We pursued two different approaches to this concept.
Microchip and Capillary Electrophoresis Using Nanoparticles (2010)

This chapter contains sections titled: Introduction Microchip Electrophoresis Application of Nanoparticles in CE and MCE Conclusions References
On quadratic adaptive routing algorithms (1976)

Two analytic models of a store-and-forward communications network are constructed, one to find the optimal message routing and the other to illustrate the equilibrium (stationary state) maintained by an adaptive routing algorithm. These models show that adaptive routing does not satisfy the necessary conditions for an optimal routing. Adaptive routing tends to overuse the direct path and underuse alternate routes because it does not consider the impact of its current routing decision on the future state of the network. The form of the optimality conditions suggests that a modification of the adaptive algorithm will result in optimality. The modification requires the substitution of a quadratic bias term instead of a linear one in the routing table maintained at each network node. Simulation results are presented which confirm the theoretical analysis for a simple network.
José Mariano Beristáin, Diario Pinciano. Primer Periódico de Valladolid (1787-1788) (1995)

Reseña sobre José Mariano Beristáin, Diario Pinciano. Primer Periódico de Valladolid (1787-1788), segunda reproducción facsímil, estudio preliminar de Celso Almuiña Fernández, Valladolid, Grupo Pinciano con la colaboración de Caja de Ahorros Provincial de Valladolid, 1978.
Electronic and magnetic structures of the rare-earth compounds<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="italic">R</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Fe</mml:mi></mml:mrow><mml:mrow><mml:mn>17</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">N</mml:mi></mml:mrow><mml:mrow><mml:mo>ξ</mml:mo></mml:mrow></mml:msub></mml:mrow></mml:math> (1991)

Structural and magnetic properties of the rare-earth compounds ${\mathit{R}}_{2}$${\mathrm{Fe}}_{17}$${\mathrm{N}}_{\ensuremath{\xi}}$ have been studied with neutron-diffraction measurements and self-consistent spin-polarized electronic-structure calculations. The diffraction results indicate for the Nd compound that N goes into two sites in two or more phases of varying fractional N occupations. For the Y compound N occupies only one site. Electronic-structure calculations for ${\mathrm{Y}}_{2}$${\mathrm{Fe}}_{17}$ and ${\mathrm{Y}}_{2}$${\mathrm{Fe}}_{17}$${\mathrm{N}}_{3}$ give excellent results for site-dependent Fe moments, and, with spin-fluctuation theory, explain the large change in the Curie temperature on nitrogenation.
CamSwarm: Instantaneous Smartphone Camera Arrays for Collaborative Photography (2015)

Camera arrays (CamArrays) are widely used in commercial filming projects for achieving special visual effects such as bullet time effect, but are very expensive to set up. We propose CamSwarm, a low-cost and lightweight alternative to professional CamArrays for consumer applications. It allows the construction of a collaborative photography platform from multiple mobile devices anywhere and anytime, enabling new capturing and editing experiences that a single camera cannot provide. Our system allows easy team formation; uses real-time visualization and feedback to guide camera positioning; provides a mechanism for synchronized capturing; and finally allows the user to efficiently browse and edit the captured imagery. Our user study suggests that CamSwarm is easy to use; the provided real-time guidance is helpful; and the full system achieves high quality results promising for non-professional use. A demo video is provided at https://www.youtube.com/watch?v=LgkHcvcyTTM.
Performance modeling for the panda array I/O library (1996)

We present an analytical performance model for Panda, a library for synchronized i/o of large multidimensional arrays on parallel and sequential platforms, and show how the Panda developers use this model to evaluate Panda's parallel i/o performance and guide future Panda development. The model validation shows that system developers can simplify performance analysis, identify potential performance bottlenecks, and study the design trade-offs for Panda on massively parallel platforms more easily than by conducting empirical experiments. More importantly, we show that the outputs of the performance model can be used to help make optimal plans for handling application i/o requests, the first step toward our long-term goal of automatically optimizing i/o request handling in Panda.
Development and Population Study of an Eight-Locus Short Tandem Repeat (STR) Multiplex System (1998)

Amplification of short tandem repeat (STR) loci has become a useful tool for human identification applications. To improve throughput and efficiency for such uses, the polymorphic STR loci CSF1PO, TPOX, TH01, vWA, D16S539, D7S820, D13S317, D5S818, F13A01, FESFPS, F13B, and LPL have been evaluated, developed, and configured into fluorescently labeled multiplex systems. Eight of these STR loci were combined to generate the PowerPlex System, a two-color multiplex system that supports rapid, accurate, reliable analysis and designation of alleles. The remaining four loci comprise the FFFL System, a one-color multiplex system. The PowerPlex System may be evaluated alternatively as two one-color, four-locus multiplex systems, CTTv Multiplex and GammaSTR Multiplex. The products of multiplex amplification may be analyzed with a variety of fluorescence detection instruments. Determination of genotypes of over 200 individuals from each of three different population/ethnic groups revealed independence of inheritance of the loci and allowed calculation of matching probability, typical paternity index, and power of exclusion for each multiplex.
Lipoxin A<sub>4</sub> levels in asthma: relation with disease severity and aspirin sensitivity (2007)

This study indicated that diminished LX A4 generation was unique to severe asthma phenotype regardless of comorbid aspirin sensitivity. Clinical Implications Lower LX A4 levels in severe asthma would suggest a possibility for LX analogues as future treatment options in these patients.
Ovarian small cell carcinoma of hypercalcemic type – evidence of germline origin and smarca4 gene inactivation. a pilot study (2013)

Ovarian tumors from two patients, compatible by histological and immunohistochemical criteria with small cell carcinoma of hypercalcemic type (SCCHT) (WT1+, EMA dispersed+, synaptophysin+ or dispersed+), were extensively sampled in order to find clues to their histogenesis. Subsequently, small foci of immature teratoma were found in both of them (in 1/122 and in 3/80 tumor sections). In one case, microfoci of yolk sac tumor were also present within the teratoma area as well as in the background of the small cell tumor population - in the primary tumor and in omental metastasis. We found a resemblance of the microscopic patterns of SCCHT and atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system, and this prompted us to evaluate INI-1 and SMARCA4 immunohistochemical expression, because their alternative loss is regarded as a molecular hallmark of AT/RT. INI-1 expression was retained, while that of SMARCA4 was lost. We therefore analyzed tumor DNA by PCR amplification and sequencing for mutations in the SMARCA4 gene (NG_011556.1), which were identified in both tumors (c.2184_2206del; nonsense c.3277C>T - both in one tumor; nonsense c.3760G>T in another tumor). These data suggest that SCCHT is most likely an embryonal tumor originating from immature teratoma and related to malignant rhabdoid tumor. Further analyses are necessary to determine whether the tumors diagnosed as SCCHT constitute a homogeneous group or represent more than one entity.
Poly(N-isopropylacrylamide)-based thermoresponsive surfaces provide new types of biomedical applications (2017)

Thermoresponsive surfaces, prepared by grafting of poly(N-isopropylacrylamide) (PIPAAm) or its copolymers, have been investigated for biomedical applications. Thermoresponsive cell culture dishes that show controlled cell adhesion and detachment following external temperature changes, represent a promising application of thermoresponsive surfaces. These dishes can be used to fabricate cell sheets, which are currently used as effective therapies for patients. Thermoresponsive microcarriers for large-scale cell cultivation have also been developed by taking advantage of the thermally modulated cell adhesion and detachment properties of thermoresponsive surfaces. Furthermore, thermoresponsive bioseparation systems using thermoresponsive surfaces for separating and purifying pharmaceutical proteins and therapeutic cells have been developed, with the separation systems able to maintain their activity and biological potency throughout the procedure. These applications of thermoresponsive surfaces have been improved with progress in preparation techniques of thermoresponsive surfaces, such as polymerization methods, and surface modification techniques. In the present review, the various types of PIPAAm-based thermoresponsive surfaces are summarized by describing their preparation methods, properties, and successful biomedical applications.
Immunization of mice with<i>Lactobacillus casei</i>expressing intimin fragments produces antibodies able to inhibit the adhesion of enteropathogenic<i>Escherichia coli</i>to cultivated epithelial cells (2008)

Enteropathogenic Escherichia coli (EPEC) are frequently isolated as a cause of infantile diarrhea in developing countries. Its pathogenicity is distinguished by histopathological alterations at the site of infection, known as attaching and effacing (A/E) lesions, in which bacterial virulence factors and host proteins participate. Intimin, a bacterial adhesin expressed by all EPEC described to date, is responsible for the intimate adherence of the bacteria to host cells and is essential for the formation of A/E lesions. Mucosal vaccination may represent an efficacious intervention to prevent EPEC infection and lower morbidity and mortality rates. Strategies for mucosal vaccinations that use lactic acid bacteria for the delivery of heterologous antigens rely on their safety profile and ability to stimulate the immune system. In the present work, we have constructed Lactobacillus casei strains expressing different fragments of intimin beta, a subtype that is frequently expressed by EPEC strains. Mucosal immunization of mice with L. casei expressing intimin fragments induced specific systemic and mucosal antibodies. These antibodies were able to recognize native intimin on the surface of EPEC and to inhibit in vitro EPEC binding to epithelial cells.
Understanding biocatalyst inhibition by carboxylic acids (2013)

Carboxylic acids are an attractive biorenewable chemical in terms of their flexibility and usage as precursors for a variety of industrial chemicals. It has been demonstrated that such carboxylic acids can be fermentatively produced using engineered microbes, such as Escherichia coli and Saccharomyces cerevisiae. However, like many other attractive biorenewable fuels and chemicals, carboxylic acids become inhibitory to these microbes at concentrations below the desired yield and titer. In fact, their potency as microbial inhibitors is highlighted by the fact that many of these carboxylic acids are routinely used as food preservatives. This review highlights the current knowledge regarding the impact that saturated, straight-chain carboxylic acids, such as hexanoic, octanoic, decanoic, and lauric acids can have on E. coli and S. cerevisiae, with the goal of identifying metabolic engineering strategies to increase robustness. Key effects of these carboxylic acids include damage to the cell membrane and a decrease of the microbial internal pH. Certain changes in cell membrane properties, such as composition, fluidity, integrity, and hydrophobicity, and intracellular pH are often associated with increased tolerance. The availability of appropriate exporters, such as Pdr12, can also increase tolerance. The effect on metabolic processes, such as maintaining appropriate respiratory function, regulation of Lrp activity and inhibition of production of key metabolites such as methionine, are also considered. Understanding the mechanisms of biocatalyst inhibition by these desirable products can aid in the engineering of robust strains with improved industrial performance.
Distributed feedback laser action from polymeric waveguides doped with oligo phenylene vinylene model compounds (2000)

We report lasing studies of poly(styrene) waveguides doped with amino- and cyano-substituted oligo phenylene vinylene (distyryl benzene) model compounds under picosecond excitation. Optical feedback is provided by distributed Bragg gratings formed in the film by interference patterns in the pump beam. We demonstrate broad tunability of laser emission in these materials and simultaneous lasing at two wavelengths separated by 23 nm. Tuning ranges of the model compounds are compared with previous experiments.
Cognitive Factors in the Use of Menus and Trees: An Experiment (1983)

Users without prior computer experience employed a menu-and-tree interface to search a database relevant to telecommunications services. Detailed data were recorded on the latency of each response and whether an error was made. The depth, level, vertical position, number of options, and trial were found to significantly affect response latency. The level, content, and side of the screen on which the choice was displayed significantly affected error rate. The results of the experiment and additional issues in cognitive human factors are discussed.
Blood glucose and insulin levels in normal subjects following a meal with and without added sugar beet pulp. (1981)

The fibrous components of sugar beet pulp were investigated to determine whether they would reduce the post-prandial rise in blood glucose and plasma insulin levels when incorporated into a mixed meal. On two separate occasions six healthy volunteers were given either a control meal (providing 86 g carbohydrate) or an identical meal with the addition of 20 g sugar beet pulp (test meal). Blood glucose and plasma insulin levels were measured post-prandially for 3 hours. There was no significant difference between the mean blood glucose of plasma insulin curves at any time after the two meals. Since viscous types of dietary fibers are known to be effective in reducing post-prandial hyperglycaemia and insulinaemia, it would seem that either the physio-chemical nature of the fibre or the procedure employed to extract the sugar renders the particulate fibre inactive.
Mercury-199 NMR of the Metal Receptor Site in MerR and Its Protein-DNA Complex (1995)

Structural insights have been provided by mercury-199 nuclear magnetic resonance (NMR) into the metal receptor site of the MerR metalloregulatory protein alone and in a complex with the regulatory target, DNA. The one- and two-dimensional NMR data are consistent with a trigonal planar Hg-thiolate coordination environment consisting only of Cys side chains and resolve structural aspects of both metal ion recognition and the allosteric mechanism. These studies establish 199Hg NMR techniques as useful probes of the metal coordination environment of regulatory proteins, copper enzymes, and zinc transcription factor complexes as large as 50 kilodaltons.