gebhart/patrepeval huggingface dataset:
The adjuvant effect of pertussis endotoxin protein in modulating the immune response to cholera toxoid in mice. (1985)

Endotoxin protein represents a group of immunobiologically active p polypeptides which are associated with the lipopolysaccharide endotoxin in the outer membrane of Gram-negative bacteria. To study the adjuvant effect of endotoxin protein, CF-1 mice were immunized intraperitoneally with graded doses of glutaraldehyde-inactivated cholera toxoid with and without endotoxin protein prepared from Bordetella pertussis, Salmonella typhi or Vibrio cholerae. Immune responsiveness was assessed by measuring resistance to intravenous challenge with cholera enterotoxin and by serum antitoxin responses. The results showed that endotoxin protein from S. typhi can enhance the 50% protective dose (PD50) of cholera toxoid five to 12-fold, the endotoxin protein from V. cholerae enhances the PD50 six to seven fold at most, but the endotoxin protein from B. pertussis can enhance the PD50 some 27-fold. Furthermore, within the variability of both the mouse protection test and the rabbit intracutaneous assay of toxin induced vascular permeability, mouse serum neutralizing antitoxin levels correlated with the greater degree of resistance of the mice to the toxin challenge. The adjuvant effect also has been demonstrated by measuring the appearance of antitoxin specific plaque forming cells derived from mouse lymphocyte cultures. After seven days of culture in the presence of endotoxin protein and cholera toxoid, the number of plaque forming cells to cholera toxin coated sheep erythrocytes was enhanced some 28 times as compared to the cultures exposed to the cholera toxoid alone.
Great Britain (1953)

Essay| February 01 1953 Great Britain: An Island View Alzada Comstock Alzada Comstock Professor of Economics, Mount Holyoke College Search for other works by this author on: This Site PubMed Google Scholar Current History (1953) 24 (138): 80–84. https://doi.org/10.1525/curh.1953.24.138.80 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Alzada Comstock; Great Britain: An Island View. Current History 1 February 1953; 24 (138): 80–84. doi: https://doi.org/10.1525/curh.1953.24.138.80 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCurrent History Search This content is only available via PDF. © 1953 by The Regents of the University of California1953 Article PDF first page preview Close Modal You do not currently have access to this content.
Near-field second harmonic generation from a rough metal surface (1997)

Local second-harmonic generation (SHG) from a rough metal surface has been measured using a near-field optical microscope. The dependence of the SH signal on the tip-surface distance for excitation with $S$- and $P$-polarized light shows the presence of evanescent SH field components. With excitation by $S$-polarized light the SHG over the rough surface is found to be strongly related to surface topography. For $P$-polarized light excitation, local enhancement of SH emission have been observed that may be attributed to SH field localization.
Dynamic Analysis and Structure Optimization of Linear Vibration Screen (2013)

Simulation of simplified the part structures of vibration screen by ANSYS software, and then establishes the finite element model of the linear vibration screen. Modal analysis and harmonic analysis of finite element model, and then according to the analysis results corresponding local structural modifications and adjust the center of mass of the modified vibration screen. Last verified the rationality of structure optimization.
A Study on the Communication Strategy to Risk Management of Agri-marine Products Distribution Policy (2008)

The present study attempted to explore effective scanning and monitoring in process of risk management on agri-marine products distribution policy. The interest public's group interests clash in accordance with theme for issue on marking policy. For executing a better systematic scanning and monitoring on actual affairs of marketing, selecting information personnel, gathering and analysing information, issue and risk management and their valuation with ongoing and simultaneously. Especially, In order to explore effective scanning and monitoring as a model of risk management, the study attempted to analyze within and without environment of marketing, to analyze issue management strategy, to evaluate issue activity for likelihood and impact, risk cycle analysis, interest public's group concerned, grade of interest public's group threatened(power, legitimacy, willingness), rapport(staying close, credibility, meeting expectation). And the study make an ongoing observation progress of subjects, and the serious subjects need have made an close observation. The study suggested to establish friendly relationship between organization and interest public's group, and to regularly accomplish two-way symmetric communication.
Performance Analyses of Digital Coherent Receivers with Symbol-rate Analog-to-digital Conversion (2015)

We analyze the performance of digital coherent receivers with symbol-rate analog-to-digital conversion, aiming at short/medium-reach applications (<100 km). Efficient dispersion compensation can be done even under the aliasing effect, once the clock is recovered externally.
Excel® 2010 Formulas (2010)

Maximize the power of Excel 2013 formulas with this must-have Excel reference John Walkenbach, known as "Mr. Spreadsheet," is a master at deciphering complex technical topics and Excel formulas are no exception. This fully updated book delivers more than 800 pages of Excel 2013 tips, tricks, and techniques for creating formulas that calculate, developing custom worksheet functions with VBA, debugging formulas, and much more. Demonstrates how to use all the latest features in Excel 2013 Shows how to create financial formulas and tap into the power of array formulas
Open-loop feedback control under multiple disturbance function hypotheses (2010)

We consider the control of a linear time-invariant system that is subject to a systematic, non-zero mean disturbance process drawn from a finite set of hypothesized disturbance functions. In addition to the systematic disturbance, we assume that the system is also subject to zero mean white Gaussian process and sensor noise. Using a quadratic objective function, our setting is a generalization of the well-known framework of Linear Quadratic Gaussian (LQG) control. Decomposing the state estimation problem along the lines of the hypothesized set of systematic disturbances, we derive the optimal filtering equations and corresponding Bayesian update rule for assessing the posterior probability that any given hypothesized disturbance is the one perturbing the system. We also derive the stage-by-stage optimal open-loop feedback control action, based on the current history of measurements and control actions. Finally, we present three numerical examples that illustrate the ability of OLFC to anticipate future perturbations to the system after the initial uncertainty over the hypothesized disturbance set is resolved.
Allosteric Inhibition of Rat Liver Fructose 1,6-Diphosphatase by Adenosine 5'-Monophosphate (1965)

The two major sites for glyconeogenesis in mammals are liver and kidney (2, 3).Both of these organs contain the specific enzyme, fructose 1,6-diphosphatase, which catalyzes the following reaction (4-6).n-Fructose 1,6-diphosphate Mg++ f n-fructose B-phosphateThis enzymatic step is presumed to be obligatory for glyconeogenesis in order to bypass the highly exergonic phosphofructokinase reaction (7).A sensitive mechanism for the regulation of fructose 1,6-diphosphatase activity would be of importance in control of the direction of flow of carbohydrate metabolism in these organs, i.e. catabolism via glycolysis or glycogenolysis ver.sus the anabolic process of glyconeogenesis.We have recently reported three possible mechanisms for the regulation of liver fructose 1,6-diphosphatase activity under physiological conditions (8): (a) the specific and reversible inhibition by adenosine 5'-monophosphate, (b) the reversible inhibition of the enzyme by substrate at concentrations greater than 0.1 mM, and (c) the reversible inactivation of fructose 1,6diphosphatase by reaction with ATP or ADP.This latter process could be clearly distinguished from inhibition by AMP, since the inactivation did not occur in the presence of either substrate, phosphate, or ethylenediaminetetraacetate and was not reversible by either dilution or overnight dialysis at 4".Our detailed studies on the first two of these mechanisms is the subject of the present report.Recent reports from several other laboratories have confirmed the widespread role of both AMP and fructose 1,6-diphosphate as inhibitors of fructose 1,6-diphosphatase from different sources.Weber (9) first reported inhibition of rat liver fructose 1,6-diphosphatase by excess substrate, and Newsholme (10) and Newsholme and Krebsl have obtained results similar to ours with rat liver extracts.Mendicino and Vasarhely (6) and Salas, Vifiuela, and Sols (11) have shown that both rat kidney and frog
Type Inference with Nonstructural Subtyping (1995)

We present an O(n^3) time type inference algorithm for a type<br />system with a largest type !, a smallest type ?, and the usual ordering<br />between function types. The algorithm infers type annotations of<br />minimal size, and it works equally well for recursive types. For the<br />problem of typability, our algorithm is simpler than the one of Kozen,<br />Palsberg, and Schwartzbach for type inference without ?. This may<br />be surprising, especially because the system with ? is strictly more<br />powerful.
Mycobacteria and inflammatory bowel disease (1987)

Abstract We have been able to isolate mycobacteria from intestinal specimens obtained by surgical resection or endoscopic biopsy from patients with Crohn's disease, ulcerative colitis, and noninflammatory bowel diseases. Nineteen slow-growing (Runyon groups I and III) and 17 rapid-growing (Runyon group IV) mycobacterial isolates were obtained. Slow-growing mycobacteria were recovered from approximately one-third of intestinal biopsy specimens from Crohn's disease, one-quarter of ulcerative colitis biopsies, and 40% of biopsies from noninflammatory bowel disease patients. Isolates were most commonly members of the Mycobacterium avium -complex. One isolate (from an ulcerative colitis patient) was biochemically similar to the Mycobacterium strain previously associated with Crohn's disease, and one from a Crohn's disease patient was Mycobacterium kansasii . The rapidgrowing organisms were members of the Mycobacterium fortuitum -complex. In addition to conventional mycobacteria, spheroplasts (cell wall-defective forms) were isolated from 12 patients with Crohn's disease (most often from surgically resected colon) and 3 patients with ulcerative colitis; none were isolated from non-inflammatory bowel disease patients. We have been unable to identify a consistent relationship between the presence, or the species, of Mycobacterium and Crohn's disease. Our results do not support the proposed role of a specific mycobacterium in the pathogenesis of Crohn's disease. The cause of Crohn's disease remains unclear.
Practical laboratory hematology (1991)

A reformulation of the author's original work Laboratory Hematology, this book places greater emphasis on the laboratory aspects of haematology and excludes various anaemias, white cell reactions and basic haemostasis in an attempt to bridge the gap between the haematologist and the laboratory.
Improving the Quality of Polymer-Coated Urea with Recycled Plastic, Proper Additives, and Large Tablets (2012)

Polymer-coated urea (PCU) has great potential for increasing crop production and enhancing nitrogen (N) fertilizer use efficiency, benefiting the ecosystem. However, current PCUs are used only in a limited market, and the main obstacle to the wider use of PCUs is high cost compared to that of conventional N fertilizers. In this study, the low cost PCU and large tablet polymer-coated urea (LTPCU) were prepared by using recycling polystyrene foam and various sealants as the coating materials. The structural and chemical characteristics of the coating shells of the coated fertilizers were examined. The N release characteristics of coated fertilizers were determined in 25 °C water under laboratory conditions. The relationship between the N release longevity and the amount of coating material and the percentage of different sealants were evaluated. The results indicated that recycling polystyrene foam was the ideal coating material of the controlled release fertilizer. The polyurethane that was synthesized by the reaction of castor oil and isocyanate was better than the wax as the additive to delay the N release rate of coated urea. The coating material used for LTPCU was 70-80% less than those used for commercial PCUs under the same N release longevity. The cost of the recycling polystyrene foam used for coating one ton of pure N of the LTPCU was about one-seventh to one-eighth of the cost of the traditional polymer used for the commercial PCU. The experimental data showed that the LTPCU with good controlled-release capacities, being economical and eco-friendly, could be promising for wide use in agriculture and horticulture.
New application of anti-TLR monoclonal antibodies: detection, inhibition and protection (2018)

Monoclonal antibody (mAb) is an essential tool for the analysis in various fields of biology. In the field of innate immunology, mAbs have been established and used for the study of Toll-like receptors (TLRs), a family of pathogen sensors that induces cytokine production and activate immune responses. TLRs play the role as a frontline of protection against pathogens, whereas excessive activation of TLRs has been implicated in a variety of infectious diseases and inflammatory diseases. For example, TLR7 and TLR9 sense not only pathogen-derived nucleic acids, but also self-derived nucleic acids in noninfectious inflammatory diseases such as systemic lupus erythematosus (SLE) or hepatitis. Consequently, it is important to clarify the molecular mechanisms of TLRs for therapeutic intervention in these diseases. For analysis of the molecular mechanisms of TLRs, mAbs to nucleic acid-sensing TLRs were developed recently. These mAbs revealed that TLR7 and TLR9 are localized also in the plasma membrane, while TLR7 and TLR9 were thought to be localized in endosomes and lysosomes. Among these mAbs, antagonistic mAbs to TLR7 or TLR9 are able to inhibit in vitro responses to synthetic ligands. Furthermore, antagonistic mAbs mitigate inflammatory disorders caused by TLR7 or TLR9 in mice. These results suggest that antagonistic mAbs to nucleic acid-sensing TLRs are a promising tool for therapeutic intervention in inflammatory disorders caused by excessive activation of nucleic acid-sensing TLRs. Here, we summarize the molecular mechanisms of TLRs and recent progresses in the trials targeting TLRs with mAbs to control inflammatory diseases.
Transgenic mice expressing a Huntington’s disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity (1999)

Huntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant HD gene mediates a slowly progressing striatal neurotoxicity is unknown. Glutamate receptor-mediated excitotoxicity has been hypothesized to contribute to the pathogenesis of HD. Here we show that transgenic HD mice expressing exon 1 of a human HD gene with an expanded number of CAG repeats (line R6/1) are strongly protected from acute striatal excitotoxic lesions. Intrastriatal infusions of the N-methyl-D-aspartate (NMDA) receptor agonist quinolinic acid caused massive striatal neuronal death in wild-type mice, but no damage in transgenic HD littermates. The remarkable neuroprotection in transgenic HD mice occurred at a stage when they had not developed any neurological symptoms caused by the mutant HD gene. At this stage there was no change in the number of striatal neurons and astrocytes in untreated R6/1 mice, although the striatal volume was decreased by 17%. Moreover, transgenic HD mice had normal striatal levels of NMDA receptors, calbindin D28k (calcium buffer), superoxide dismutase activity (antioxidant enzyme), Bcl-2 (anti-apoptotic protein), heat shock protein 70 (stress-induced anti-apoptotic protein), and citrate synthase activity (mitochondrial enzyme). We propose that the presence of exon 1 of the mutant HD gene induces profound changes in striatal neurons that render these cells resistant to excessive NMDA receptor activation.
Pyrolysis chemistry of poly(organosilazanes) to silicon ceramics (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrolysis chemistry of poly(organosilazanes) to silicon ceramicsHelen N. Han, David A. Lindquist, John S. Haggerty, and Dietmar SeyferthCite this: Chem. Mater. 1992, 4, 3, 705–711Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/cm00021a038https://doi.org/10.1021/cm00021a038research-articleACS PublicationsRequest reuse permissionsArticle Views340Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Topical hemostatic agents for bone bleeding in humans. A quantitative comparison of gelatin paste, gelatin sponge plus bovine thrombin, and microfibrillar collagen. (1978)

The three topical hemostatic agents--gelatin paste, microfibrillar collagen, and gelatin sponge soaked in thrombin--individually were effective in reducing bleeding from cancellous bone, as tested on the femoral surface of trochanteric osteotomies during total hip replacement. During a three-minute interval, the spontaneous reduction in bleeding in eight control hips to which no agent was applied was 11 per cent. Gelatin paste gave a reduction of 85 per cent; gelatin sponge soaked in thrombin, a reduction of 75 per cent; and microfibrillar collagen, a reduction of 47 per cent. None of these agents interfered with healing of the trochanteric osteotomy.
Preparation of Cu-SiO2 composite aerogel by ambient drying and the influence of synthesizing conditions on the structure of the aerogel (2011)

A copper-doped silica composite aerogel with high specific surface area was prepared using a sol-gel method at ambient pressure. A drying control chemical additive (DCCA) N,N-dimethylformamide (DMF) was introduced to the composite sol of tetraethyl orthosilicate (TEOS) and copper nitrate (Cu(NO3)2·3H2O) during the synthesizing process. The influence of the preparation conditions including Cu loading, catalyst concentration and heat treatment on the structure of copper-doped silica was investigated. The results showed that the obtained aerogel particles were uniformly distributed. The pore diameter was in a range of 2 to 15 nm. Heavier Cu loading benefited the formation of CuO crystalline, and reduced the specific surface area and pore diameter. When the catalyst concentration was high, the aggregation of Si-O network was reduced with the increase of it. The composite aerogel exhibited a good thermal stability after the heat treatment at high temperature.
Prohibitin promotes apoptosis of promyelocytic leukemia induced by arsenic sulfide (2015)

Arsenic sulfide (As4S4), an oral form of arsenic agent, has been shown to have similar efficacy and safety to intravenous arsenic trioxide in the treatment of acute promyelocytic leukemia (APL). The aim of the present study was to identify proteins modulated by As4S4 and to determine their involvement in the apoptotic pathway. We used comparative proteomic analysis to screen and identify the proteins that were differentially expressed with As4S4 treatment. Prohibitin (PHB) was selected for its diverse role and its increased expression in the cells treated with As4S4. To examine whether PHB play a functional role, two clones of PHB-knockdown and PHB-overexpression were generated by transfection of NB4-R1 with vectors containing PHB gene sequences. In comparison with parental NB4-R1 cells, PHB overexpression showed an increase in baseline apoptosis and an enhanced response in As4S4-induced apoptosis. PML-RARα fusion protein was found to be reduced with PHB-overexpression, and following As4S4 treatment, a greater reduction of promyelocytic leukemia-retinoic acid receptor-α (PML-RARα) fusion protein was seen in PHB-overexpression than that in parental cells. Consistently, PHB knockdown presented with a significant reduction in As4S4-induced apoptosis and a lesser degree of PML-RARα degradation. The results indicate the antitumor activity of PHB in promoting apoptosis of APL cells.
Inverse matrix evaluation for linear systems (2001)

This paper is concerned with an iterative method to recover the system matrix for a linear time-invariant dynamical system. It uses the states as given data and generates a series of simulations, after which it is possible to directly invert for the sought after matrix. It requires the solution to a nonlinear algebraic matrix equation. Numerical results indicate that the algorithm requires only a few iterations to converge to the true solution. The effect of noise on the accuracy of the results is also investigated.
Synthetic aperture radar/LANDSAT MSS image registration (1979)

Algorithms and procedures necessary to merge aircraft synthetic aperture radar (SAR) and LANDSAT multispectral scanner (MSS) imagery were determined. The design of a SAR/LANDSAT data merging system was developed. Aircraft SAR images were registered to the corresponding LANDSAT MSS scenes and were the subject of experimental investigations. Results indicate that the registration of SAR imagery with LANDSAT MSS imagery is feasible from a technical viewpoint, and useful from an information-content viewpoint.
Application of charge-coupled devices to infrared detection and imaging (1975)

A review of infrared sensitive charge-coupled devices (IRCCD) is presented. Operational requirements of typical IRCCD applications are briefly introduced. IRCCD devices are divided into two major categories: a) Monolithic devices, which essentially extend the original CCD concept into the IR. Monolithic IRCCD's discussed include inversion-mode devices (with narrow bandgap semiconductor substrate), accumulation-mode devices (extrinsic wide bandgap semiconductor substrate), and Schottky-barrier devices (internal photoemission), b) Hybrid devices, in which the functions of detection and signal processing are performed in separate but integratable components by an array of IR detectors and a silicon CCD shift register unit. Hybrid IRCCD's discussed include both direct injection devices (in conjunction with photovoltaic IR detectors) and indirect injection devices (in conjunction with pyroelectric and photoconductive devices).