gebhart/patrepeval huggingface dataset:
Selective Chemistry of Metal Oxide Atomic Layer Deposition on Si Based Substrate Surfaces (2015)

A versatile home-made atomic layer deposition (ALD) reactor was designed and built in our lab. This reactor can be used to deposit metal oxides on both wafer substrates and porous inorganic particles. Also, a simple procedure for selective ALD has been developed for the processing of silicon wafers in order to facilitate the spatially resolved growth of thin solid films on their surfaces. Specifically, a combination of silylation and UV/ozonolysis was tested as a way to control the concentration of the surface hydroxo groups required for subsequent atomic layer deposition (ALD) of metals or oxides. Water contact angle measurements were used to evaluate the hydrophilicity/hydrophobicity of the surface, a proxy for OH surface coverage, and to optimize the UV/ozonolysis treatment. Silylation with silanes was found to be an efficient way to block the hydroxo sites and to passivate the underlying surface, and UV/O3treatments were shown to effectively remove the silylation layer and to regain the surface reactivity. Both O3 and 185 nm UV radiation were determined necessary for the removal of the silylation layer, and additional 254 nm radiation was found to enhance the process. Attenuated total reflection-infrared absorption spectroscopy was employed to assess the success of the silylation and UV/O3 removal steps, and atomic force microscopy data provided evidence for the retention of the original smoothness of the surface. Selective growth of HfO2 films via TDMAHf + H2O ALD was seen only on the UV/O3 treated surfaces; total inhibition of the deposition was observed on the untreated silylated surfaces. We believe that the silylation-UV/O3 procedure advanced here could be easily implemented for the patterning of surfaces in many microelectronic applications.
Unicompartmental mobile-bearing knee arthroplasty. (2005)

Two diferent mobile-bearing unicompartmental knee replacement designs have been available since the late 1970s. The primary difference between these two designs is that one has a constrained bearing in a track and the other has a freely moving bearing. Both implants are currently indicated for the treatment of patients with medial unicompartmental osteoarthritis and are available for use in the United States. The benefits of such designs are restoration of normal knee joint kinematics and protection of the polyethylene by reduction of high-contact stresses that occur with nonmobile-bearing designs. Experience has shown that careful patient selection and careful surgical technique both are factors critical to the success of mobile-bearing unicompartmental knee implants. The most important patient selection criteria have proved to be the diagnosis of anteromedial osteoarthritis with a passively correctable varus deformity and intact anterior cruciate ligament. Precise instrumentation is necessary to consistently balance and align a mobile-bearing implant. Ten-year survivorship data for freely mobile-bearing implants are available from multiple centers that show survivorship rates ranging from 85% to 98%, which are comparable to survivorship rates for total knee replacement.
Effect of Bleomycin on Peripheral Lymphocytes (1977)

Five patients with carcinoma of the penis receiving radiation therapy and injections of Bleomycin were examined to determine whether Bleomycin affects the peripheral pool of lymphoid cells. Total lymphocyte counts were not decreased, but transient reduction of the frequency of thymus-dependent cells occurred in 3 patients. The responses of the lymphocytes to phytomitogens and PPD were temporarily decreased these 3 patients. In 2 subjects the phytomitogen reactivity of the lymphocytes was improved after treatment.
The transforming growth factor- 1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD) (2004)

Although cigarette smoking is the primary environmental risk factor, genetic risk factors likely influence the development of chronic obstructive pulmonary disease (COPD). Linkage analysis between short-tandem repeat markers on chromosome 19 and COPD phenotypes was followed by association analysis of single nucleotide polymorphisms in a gene on chromosome 19q [transforming growth factor-beta1 (TGFB1)] and COPD phenotypes in a family-based sample and a case-control study (cases with severe COPD and control subjects with significant history of smoking but no COPD). Stratification by smoking status substantially improved the evidence of linkage to chromosome 19q for COPD phenotypes. Among former and current smokers in the Boston Early-Onset COPD Study, there was significant evidence of linkage between chromosome 19q and pre-bronchodilator (pre-BD) FEV(1) (LOD=3.30) and suggestive evidence of linkage between chromosome 19q and other COPD phenotypes. In these families, a SNP in the promoter region of TGFB1 (rs2241712) and two SNPs in the 3' genomic region of TGFB1 (rs2241718 and rs6957) were significantly associated with pre- and post-BD FEV(1) (P<0.05). Among smokers in the COPD cases and control subjects, two SNPs in the promoter region of TGFB1 (rs2241712 and rs1800469) and one SNP in exon 1 of TGFB1 (rs1982073) were significantly associated with COPD (P</=0.02 in all cases). Chromosome 19q likely contains a genetic locus (or loci) that influences COPD through an interaction with cigarette smoking. We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers.
Induction of hypothermia, hypoglycemia and hyperinsulinemia after acute leptin immunoneutralization in overnight fasted mice. (1998)

Acute immunoneutralization of circulating leptin, with an anti-leptin antibody, significantly reduced rectal temperature at 30 min and 75 min post-injection in overnight fasted and at 30 min in overnight fed mice, while no effects in metabolic and ponderal indicators were observed after antibody administration for 22 days. Furthermore, hyperinsulinemia and hypoglycemia were induced by passive immunization against leptin, being both influenced by the post-prandrial status. These experiments confirm through an indirect approach that leptin is involved in energy, but also in glucose homeostasis.
Extraction of Spectral Channels From Hyperspectral Images for Classification Purposes (2007)

This paper proposes a procedure to extract spectral channels of variable bandwidths and spectral positions from the hyperspectral image in such a way as to optimize the accuracy for a specific classification problem. In particular, each spectral channel ("s-band") is obtained by averaging a group of contiguous channels of the hyperspectral image ("h-bands"). Therefore, if one wants to define m s-bands, the problem can be formulated as the optimization of the related m starting and m ending h-bands. Toward this end, we propose to adopt, as an optimization criterion, an interclass distance computed on a training set and to generate a sequence of possible solutions by one of three possible search strategies. As the proposed formalization of the problem makes it analogous to a feature-selection problem, the proposed three strategies have been derived by modifying three feature-selection strategies, namely: 1) the "sequential forward selection", 2) the "steepest ascent," and 3) the "fast constrained search". Experimental results on a well-known hyperspectral data set confirm the effectiveness of the approach, which yields better results than other widely used methods. The importance of this kind of procedure lies in feature reduction for hyperspectral image classification or in the case-based design of the spectral bands of a programmable sensor. It represents a special case of feature extraction that is expected to be more powerful than feature selection. The kind of transformation used allows the interpretability of the new features (i.e., the spectral bands) to be saved
Wiskott-Aldrich syndrome: cellular impairments and their implication for carrier detection (1980)

A family in which two male siblings were affected with Wiskott-Aldrich syndrome (WAS) was studied using G-6-PD isoenzymes as an X-linked marker in order to investigate the nature of cellular abnormalities. Isolated peripheral blood cell types from the doubly heterozygous mother of the affected males seemingly failed to express the G-6-PD allele in cis position with the WAS allele while her cultured skin fibroblasts expressed both G-6-PD alleles. Additionally, a histogram analysis of platelet size revealed a single population of abnormally small platelets in the affected propositus, whereas the heterozygous mother had no appreciable small platelet subpopulation. In vitro culture of hemopoietic progenitor cells of the heterozygous mother showed that the majority of progenitor cells did not express the WAS allele. However, a small number of cells expressing the G-6-PD type linked with the WAS allele were detected. The proportion of the latter progenitors was significantly higher among more primitive progenitors (those giving rise to later appearing colonies). This observation suggests that selection against cells expressing the Wiskott-Aldrich defect takes place in the hemopoietic system of the heterozygous female and offers a possible means of carrier detection in some women. Linkage studies in this family revealed one example of probable recombination between the loci for WAS and G-6-PD among three informative subjects, suggesting that these two loci may not be closely linked on the X-chromosome.
Tissue Distribution and Characterization of Soluble and Membrane-bound Forms of Metallocarboxypeptidase D (1996)

Metallocarboxypeptidase D (CPD) is a recently discovered 180-kDa membrane-bound carboxypeptidase E-like enzyme (Song, L. and Fricker, L. D. (1995) J. Biol. Chem. 270, 25007-25013). In the present study, a soluble CPD-like activity has been purified to homogeneity and characterized. On denaturing polyacrylamide gels, the soluble enzyme from bovine pituitary glands appears as two bands of 170 and 135 kDa which are converted to 155 and 115 kDa by endoglycosidase F. Both of the soluble forms of CPD are recognized by an antisera raised against CPD purified from rat brain membranes. The partial N-terminal amino acid sequences of the two soluble forms are identical to each other and to the predicted N terminus of duck gp180. The soluble and membrane forms of CPD have similar pH optima, inhibitor specificities, and kinetic parameters for substrate hydrolysis. CPD-like enzymatic activity is detected in all rat tissues examined, with highest levels in pituitary, brain, and adrenal. Western blot analysis indicates that both soluble and membrane forms of CPD are present in rat brain, heart, liver, and kidney. At least four distinct 100-180-kDa forms of CPD are detected on Western blots, although an antiserum raised against the C-terminal region of rat CPD recognizes only the 180-kDa membrane-bound form. The finding that CPD is widely distributed suggests a broad role for this enzyme in the processing of proteins that transit the secretory pathway.
The ageing ovary and uterus: new biological insights (2012)

BACKGROUND Advanced maternal age is associated with reduced fertility and adverse pregnancy outcomes. This review details recent developments in our understanding of the biology and mechanisms underlying reproductive ageing in women and the implications for fertility and pregnancy. METHODS Sociological online libraries (IBSS, SocINDEX), PubMed and Google Scholar were searched for relevant demographic, epidemiological, clinical and biological studies, using key words and hierarchical MeSH terms. From this, we identified and focused on key topics where it was judged that there had been clinically relevant advances in the understanding of ovarian and uterine ageing with implications for improved diagnostics and novel interventions. RESULTS Mapping of the ovarian reserve, follicular dynamics and associated biomarkers, across the reproductive lifespan has recently been performed. This now allows an assessment of the effects of environmental, lifestyle and prenatal exposures on follicular dynamics and the identification of their impact during periods of germ cell vulnerability and may also facilitate early identification of individuals with shorter reproductive lifespans. If women choose to time their family based on their ovarian reserve this would redefine the meaning of family planning. Despite recent reports of the potential existence of stem cells which may be used to restore the primordial follicle and thereby the oocyte pool, therapeutic interventions in female reproductive ageing at present remain limited. Maternal ageing has detrimental effects on decidual and placental development, which may be related to repeated exposure to sex steroids and underlie the association of ageing with adverse perinatal outcomes. CONCLUSIONS Ageing has incontrovertible detrimental effects on the ovary and the uterus. Our enhanced understanding of ovarian ageing will facilitate early identification of individuals at greatest risk, and novel therapeutic interventions. Changes in both ovary and uterus are in addition to age-related co-morbidities, which together have synergistic effects on reducing the probability of a successful pregnancy outcome.
Use of highly elliptical core fibers for two-mode fiber devices (1987)

The four complex, almost degenerate, second-order eigenmodes of a two-mode fiber having a circular core are reduced to two nondegenerate, linearly polarized second-order eigenmodes with stable-intensity lobe positions in a highly elliptical core fiber. Existing two-mode-fiber devices can be improved by this stabilization of the second-order modes. Practical sensors employing the two spatial modes as the two arms of an interferometer are described. The two arms of an interferometer of this type can have the same group delays, while the difference in phase delays is large.
The selection of mechanical actuators based on performance indices (1997)

A method is presented for selecting the type of actuator best suited to a given task, in the early stages of engineering design. The selection is based on matching performance characteristics of the actuator, such as force and displacement, to the requirements of the given task. The performance characteristics are estimated from manufacturers' data and from simple models of performance limitation such as heat generation and resonance. Characteristics are presented in a graphical form which allows for a direct and systematic comparison of widely different systems of actuation. The actuators considered include man-made actuators (such as hydraulic, solenoid and shape memory alloy) and naturally occurring actuators (such as the muscles of animals and plants).
Physicochemical Characterization and Ecotoxicological Assessment of CeO2 Nanoparticles Using Two Aquatic Microorganisms (2010)

The physicochemical properties of nanoparticles determine their interaction with living organisms. Four different cerium oxide nanoparticles, including commercial materials, were characterized and compared with a micron-sized ceria. The formation of aggregates as well as ζ-potential, surface area, and chemical composition were determined. The formation of primary particle aggregates was a slow process that led to different particle sizes depending on the composition of the medium. In this paper, we describe the toxicity of cerium oxide for the self-luminescent cyanobacterial recombinant strain Anabaena CPB4337 and the green alga Pseudokirchneriella subcapitata. The toxicity for Anabaena exposed to nanoparticles in pure water for 24 h ranged from 0.27 to 6.3 mg/l; P. subcapitata EC(50) (yielded effective concentration of nanoparticles that inhibits the cellular function of interest by 50%) values in the 2.4-29.6 mg/l range. Images of both organisms showed membrane disruption and highly damaged cells. Free cerium was highly toxic for both organisms, but the negligible amount found dissolved in the nanoparticle suspensions could not explain the observed toxic effect of nanoceria on the aquatic organisms; the dissolution of zinc could contribute to the toxicity of bulk material but could not explain the toxic effect of nanoceria either. We found no evidence of nanoparticle uptake by cells, but our observations suggested that their toxic mode of action required direct contact between nanoparticles and cells; in the case of the cyanobacterium, cells completely coated by layers of ceria nanoparticles were observed. Cell damage most probably took place by cell wall and membrane disruption; further research is needed to find out whether the oxidative activity of ceria could be responsible.
PHYTATE‐PROTEIN INTERACTIONS IN SOYBEAN EXTRACTS AND LOW‐PHYTATE SOY PROTEIN PRODUCTS (1979)

ABSTRACT The solubility of phytate and protein in soy extracts as influenced by pH, NaCl, calcium and EDTA was measured. The behavior of phytate is explained in terms of its binding to calcium‐magnesium and/or to proteins. Three processes for preparing low‐phytate soy protein products were derived from this theory, at both the laboratory and pilot plant scale. The nutritional properties of isolates prepared with these processes were examined.
Novel Water-Soluble Derivatives of Docosahexaenoic Acid Increase Diacylglycerol Production Mediated by Phosphatidylcholine-Specific Phospholipase C (1993)

The effect of ascorbic acid 6-docosahexaenoate (DHA-VC) on the phospholipase-C-mediated hydrolysis of phosphatidylcholine was investigated. In human non-small cell lung cancer cells (PC-14) exposed to DHA-VC for 24 hr, a dose-dependent increase in phosphatidylcholine-specific phospholipase C (PC-PLC) activity was seen. PC-PLC activity in whole-cell homogenate of PC-14 cells was increased about 2.5-fold by 2 hr of treatment with DHA-VC (20 micrograms/ml). Treatment with DHA-VC also augmented PC-PLC activity in the crude membrane extract. On the other hand, DHA-VC inhibited the activity of phospholipase A2 (ID50 = 800 micrograms/ml). Another water-soluble analog, choline docosahexaenoate, also stimulated PC-PLC activity. To explore the effect of DHA-VC on phosphatidylcholine turnover, we analyzed phospholipids labeled with [14C] choline or [3H]myristate by thin-layer chromatography, and found that the amount of [14C]- and [3H]-labeled phosphatidylcholine was constant in the presence of DHA-VC. These results suggest that phosphatidylcholine turnover was not influenced by DHA-VC. DHA-VC treatment increased protein kinase C activity of the cells in the late phase (120 min), suggesting that DHA-VC-induced diacylglycerol production mediated by PC-PLC causes protein kinase C activation. Considering that significant inhibition of DNA synthesis occurred 12 hr after 2 hr of treatment with DHA-VC (20 micrograms/ml), DHA-VC-induced PC-PLC activation seems to be an early event in DHA-VC-induced cytotoxicity, which suggests that the effects of DHA-VC on signal transduction pathways may play an important role in the cytotoxicity of DHA-VC.
능이버섯 효소 추출물의 항산화 활성 및 H 2 O 2 로 유도된 스트레스에 대한 신경보호 효과 (2011)

The antioxidative activity of various enzymatic extracts from Sarcodon aspratus (S. aspratus) was evaluated by measuring 1,1-diphenyl-2-picrylhydrazyl (DPPH), and alkyl radical scavenging activity using an electron spin resonance (ESR) spectrometer. For this study, the S. aspratus were enzymatically hydrolyzed by seven carbohydrases (Viscozyme, Celluclast, Dextrozyme, AMG, Promozyme, Maltogenase, and Termamyl) and eight proteases (α-chymotrypsin, Alcalase, Flavourzyme, Neutrase, papain, pepsin, Protamax, and trypsin). The DPPH radical scavenging activities of Viscozyme and pepsin extracts were the highest, and the half maximal inhibitory concentration (IC50) values were 0.896 and 0.734mg/mL, respectively. The Celluclast and trypsin extracts showed the highest scavenging activities on alkyl radical, and their IC50 values were 0.278 and 0.575mg/mL, respectively. The Celluclast extracts was decreased cell apoptosis in PC-12 cells against H2O2-induced oxidative damage. The findings of the present study suggest that enzymatic extracts of S. aspratus exhibit antioxidative activity against oxidative stress on PC-12 cells.
Additive Manufacturing of Sensors for Military Monitoring Applications (2021)

The US Department of Defense (DoD) realizes the many uses of additive manufacturing (AM) as it has become a common fabrication technique for an extensive range of engineering components in several industrial sectors. 3D Printed (3DP) sensor technology offers high-performance features as a way to track individual warfighters on the battlefield, offering protection from threats such as weaponized toxins, bacteria or virus, with real-time monitoring of physiological events, advanced diagnostics, and connected feedback. Maximum protection of the warfighter gives a distinct advantage over adversaries by providing an enhanced awareness of situational threats on the battle field. There is a need to further explore aspects of AM such as higher printing resolution and efficiency, with faster print times and higher performance, sensitivity and optimized fabrication to ensure that soldiers are more safe and lethal to win our nation's wars and come home safely. A review and comparison of various 3DP techniques for sensor fabrication is presented.
Gasless combustion synthesis of refractory compounds (1985)

Gasless combustion synthesis technology for the preparation of refractory compounds is described in this volume. Processes and theory are considered, with emphasis on recent Soviet technology; analytical combustion models are presented; and suggestions are made for future research directions. Gasless combustion synthesis generally involves reactions of elemental constituents in condensed phases to form refractory, often ceramic, compositions. Gasless combustion's appeal, as opposed to conventional powder-compaction technology, is its potential for using the exothermic heat of reaction to form densified ceramic product shapes in a single step, thereby avoiding the need for subsequent processing by externally supplied heat. Process advantages claimed are low fabrication and capital investment costs, extremely high processing temperatures, relatively abrupt heatup and cooldown sequences, rapid processing, and relative product purity. Areas for future research opportunities include synthesis of ceramic matric composites and complex (fracture tough) ceramic compounds, combination of synthesis reactions with isostatic pressing or with electric arc technology in hard surfacing operations, and the casting of composite materials in a zero-gravity environment.
Enhanced ferroelectric properties in Mn-doped K0.5Na0.5NbO3 thin films derived from chemical solution deposition (2010)

Mn-doped K0.5Na0.5NbO3 (KNN) thin films derived from chemical solution deposition have been investigated. 2 mol % manganese acetate was introduced into the polyvinylpyrrolidone-modified KNN precursor solution to prepare the KNN thin films. It was found that Mn doping can increase the dielectric constant and decrease the dielectric loss, as well as significantly decrease the leakage current. The leakage current density of Mn-doped KNN film is about 3×10−6 A/cm2 at an electric field of 50 kV/cm, which is 104 times lower than that of the undoped film (about 3×10−2 A/cm2). These are attributed to the decrease in the concentration in oxygen vacancies and free carrier-holes by increasing the valence of Mn during thermal treatment. As a result, well saturated polarization-electric field hysteresis loops were obtained in the Mn-doped KNN thin films.