gebhart/patrepeval huggingface dataset:
O<sup>6</sup>‐methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells (2006)

Temozolomide (TMZ) is a methylating agent which prolongs survival when administered during and after radiotherapy in the first-line treatment of glioblastoma and which also has significant activity in recurrent disease. O6-methylguanine DNA methyltransferase (MGMT) is a DNA repair enzyme attributed a role in cancer cell resistance to O6-alkylating agent-based chemotherapy. Using a panel of 12 human glioma cell lines, we here defined the sensitivity to TMZ in acute cytotoxicity and clonogenic survival assays in relation to MGMT, mismatch repair and p53 status and its modulation by dexamethasone, irradiation and BCL-X(L). We found that the levels of MGMT expression were a major predictor of TMZ sensitivity in human glioma cells. MGMT activity and clonogenic survival after TMZ exposure are highly correlated (p < 0.0001, r2 = 0.92). In contrast, clonogenic survival after TMZ exposure does not correlate with the expression levels of the mismatch repair proteins mutS homologue 2, mutS homologue 6 or post-meiotic segregation increased 2. The MGMT inhibitor O6-benzylguanine sensitizes MGMT-positive glioma cells to TMZ whereas MGMT gene transfer into MGMT-negative cells confers protection. The antiapoptotic BCL-X(L) protein attenuates TMZ cytotoxicity in MGMT-negative LNT-229 but not in MGMT-positive LN-18 cells. Neither ionizing radiation (4 Gy) nor clinically relevant concentrations of dexamethasone modulate MGMT activity or TMZ sensitivity. Abrogation of p53 wild-type function strongly attenuates TMZ cytotoxicity. Conversely, p53 mimetic agents designed to stabilize the wild-type conformation of p53 sensitize glioma cells for TMZ cytotoxicity. Collectively, these results suggest that the determination of MGMT expression and p53 status will help to identify glioma patients who will or will not respond to TMZ.
Changes in Milk Protein Fraction as Affected by Subclinical Mastitis (1999)

From cows that had both healthy quarters and quarters with subclinical mastitis [somatic cell count (SCC) 84,000 vs. 293,000/ml in bucket milk], foremilk, bucket milk, and stripping and residual milks were collected. Young milk was obtained 1.5 h later following a repeated oxytocin injection. Compared with milk from healthy quarters, milk from quarters with subclinical mastitis showed elevated SCC, plasminogen, and protein and had increased activity of n-Acetyl-beta-D-glucosaminidase (NAGase) and plasmin, as well as elevated portions of whey proteins and gamma-casein in the total protein. The SCC and the other mentioned parameters were also higher in the foremilk and the stripping and residual milks compared with bucket milk, independent of the udder health status; however, decreased values were found for total protein. Young milk showed an increase of SCC and n-Acetyl-beta-D-glucosaminidase activity compared with bucket milk. Because of lower levels of total plasmin and gamma-casein, we concluded that this young milk was newly synthesized milk containing some casein degradation products and that proteolysis of casein continued in the udder until the next milking. The n-Acetyl-beta-D-glucosaminidase activity was shown to be a better indicator for subclinical mastitis and correlated better with protein degradation than did SCC.
RADIOPROTECTIVE EFFICACY AND ACUTE TOXICITY OF 5-ANDROSTENEDIOL AFTER SUBCUTANEOUS OR ORAL ADMINISTRATION IN MICE (2002)

We previously showed that one subcutaneous (sc) injection of 5-androstene-3beta,17beta-diol (AED) stimulated the innate immune system in mice and prevented mortality due to hemopoietic suppression after whole-body ionizing irradiation with gamma rays. In the present study, we tested whether there was any significant toxicity in mice that might hinder development of this steroid for human use. There were no indications of toxicity in chemical analyses of serum after sc doses as high as 4000 mg/kg. At this dose, 2 of 54 mice died when given AED alone. When 4800 mg/kg was given orally, no deaths resulted. The only adverse findings attributed to AED administration were 1) a moderate elevation of granulocytes in abdominal organs and fat after sc injections of 320 mg/kg; and 2) occasional wasting of skin over the injection site in female B6D2F1 but not male C3H/HeN mice. Significant weight loss (6%) was observed after sc injections of 320 mg/kg but not 160 or 80 mg/kg. When male C3H/HeN mice were injected sc with AED at doses of 0-200 mg/kg 24 h before whole body gamma-irradiation (9 Gy), a significant improvement in survival was observed at doses as low as 5 mg/kg. Oral administration of AED produced significant survival enhancement at a dose of 1600 mg/kg. We conclude that the radioprotective efficacy of AED is accompanied by low toxicity.
Performance Study of a Ducted Fan System (2002)

An experimental investigation was completed in the NASA Ames 7- by 10-Foot Wind Tunnel with the objective of determining the performance characteristics of a ducted fan. The model was an annular duct with a 38-in diameter, 10-in chord, and a 5-bladed fixed-pitch fan. Model variations included duct angle of attack, exit vane flap length, flap deflection angle, and duct chord length. Duct performance data were obtained for axial and forward flight test conditions. Axial flow test data showed figure of merit decreases with increasing advance ratio. Forward flight data showed an increasing propulsive force with decreasing duct angle of attack. Exit vane flap deflection angle and flap chord length were shown to be an effective way of providing side force. Extending the duct chord did not effect the duct performance. Notation Ae Duct exit area, ft2 cd Duct chord, ft CL Lift coefficient, L/qdecd CP Power coefficient, 550P/r n3d5 CT Thrust coefficient, shaft axis, T/r n2d4
Extending Open Directory Project to represent user interests (2012)

Effective inference of user interests is crucial to personalization. Utilizing the Open Directory Project (ODP) categories is an effective way to infer user interests, which represents user interests in the form of ODP categories, i.e., nouns. In this paper, we build a knowledge base to represent user interests in the form of (noun, verb) pairs. We expect that this approach will enable us to represent user interests more precisely, since verbs clarify the context of nouns. To this end, we develop a verb extraction engine that extends ODP categories with their related verbs. It employs various information sources to automatically identify a set of related verbs for an arbitrary ODP category. Thus, we obtain the extended ODP categories in the form of (noun, verb) pairs that will be utilized for various personalization services. The experimental results show the efficacy of our verb extraction engine.
A Photocurable, Photoluminescent, Polycarbosilane Obtained by Acyclic Diene Metathesis (ADMET) Polymerization (2009)

The synthesis and study of a novel thermosetting, blue photoluminescent, cyclolinear polycarbosilane (CLPCS) are reported. This cyclolinear polycarbosilane, in which disilacyclobutane (DSCB) rings alternate with trans-stilbene units (i.e., [−{cyclo-Si(CH3)(CH2)2Si(CH3)}−C6H4−CH═CH−C6H4−]n (S-CLPCS), was prepared by via acyclic diene metathesis (ADMET) polymerization. The polymer showed excellent solubility in common organic solvents and blue photoemission with a high emission quantum yield (Φ ≈ 0.65). Spin-coated polymer films were thermally or photochemically cross-linked to yield tough, insoluble films, which showed no significant decrease in photoluminescence intensity relative to that of the initial polymer film prior to cross-linking. The effect of the DSCB spacers on the processability and optical properties of the polymers was investigated by preparing a series of alkylene-spaced polycarbosilane analogues and model compounds.
FPGA implementation for real-time Chroma-key effect using Coarse and Fine Filter (2013)

Chroma-key is a robust and important technique for processing image or video that is widely used in cinema films, magazine covers, video game industries as well as television programs such as weather forecast, live talk show, ect. This paper presents study of Chroma-key method and proposes a hardware architecture for Chroma-key effect in real-time. Based on K-means algorithm, we propose an improved method namely Coarse and Fine Filter, which is more robust on segmentation and more appropriate for hardware design thanks to usage of small buffer. A VLSI architecture for the proposed method is implemented on the Altera DE2 FPGA board. Experimental results show that the proposed design can perform Chroma-key effect with pleasing quality in real-time.
Current transport in short channel top-contact pentacene field-effect transistors investigated with the selective molecular doping technique (2007)

The contact doping profile is controlled in the top-contact configuration to clarify a transistor operation based on a current injection process from the metal contact to the organic channel in a submicron channel pentacene field-effect transistor. The molecular doping in the pentacene film underneath the metal contact, in which a thin layer of iron (III) chloride was introduced, drastically changes transistor characteristics. The doping profile control directly revealed the resistive part for current injection. A model to explain the saturation behavior of the top-contact short channel organic transistor is presented.
Multiparametric analysis of cell membrane permeability by two colour flow cytometry with complementary fluorescent probes (1990)

We describe an improved twin-probe multiparameter flow cytometric technique to examine cell membrane permeability. Ability to retain preloaded intracellular bis-carboxyethyl carboxy fluorescein (BCECF, green fluorescence) and to exclude extracellular propidium (red fluorescence) is measured, simultaneously with forward and right-angle scatter. This has significant advantages over an earlier method using fluorescein together with ethidium. In addition to the two expected cell populations which were stained green positive, red negative (by convention membrane "intact" and "viable," Region 1) and green negative, red positive ("membrane-damaged" and "non-viable," Region 3), a third population was seen which fluoresced neither green nor red and displayed intermediate light scatter characteristics (Region 2). This was true for each of 9 cell types in vitro. For EMT6 mouse mammary tumour cells held under sub-optimal conditions or treated with membrane-active drugs, progression from Region 1 to Region 2 was observed, followed by further progression from Region 2 to Region 3. Cells eventually accumulated in Region 3. These results suggest that sequential changes in membrane structure lead to increased permeability, first with respect to intracellular BCECF and in turn to extracellular propidium.
GeoBrush: Interactive Mesh Geometry Cloning (2011)

Abstract We propose a method for interactive cloning of 3D surface geometry using a paintbrush interface, similar to the continuous cloning brush popular in image editing. Existing interactive mesh composition tools focus on atomic copy‐and‐paste of preselected feature areas, and are either limited to copying surface displacements, or require the solution of variational optimization problems, which is too expensive for an interactive brush interface. In contrast, our GeoBrush method supports real‐time continuous copying of arbitrary high‐resolution surface features between irregular meshes, including topological handles. We achieve this by first establishing a correspondence between the source and target geometries using a novel generalized discrete exponential map parameterization. Next we roughly align the source geometry with the target shape using Green Coordinates with automatically‐constructed cages. Finally, we compute an offset membrane to smoothly blend the pasted patch with C continuity before stitching it into the target. The offset membrane is a solution of a bi‐harmonic PDE, which is computed on the GPU in real time by exploiting the regular parametric domain. We demonstrate the effectiveness of GeoBrush with various editing scenarios, including detail enrichment and completion of scanned surfaces.
Desmosines in human urine. Amounts in early development and in Marfan's syndrome (1981)

Desmosines from 24 h human urine samples were isolated, characterized and quantified. The desmosines are in peptidyl form (1000--1500 molecular weight), and their amount is decreased by two-thirds between 7 and 25 years of age. Patients with Marfan's syndrome have significantly lower urinary amounts of desmosines than do comparable controls during the early development period.
8-Amino-7-chloro-s-triazolo[4,3-c]pyrimidine and Related Compounds<sup>1</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT8-Amino-7-chloro-s-triazolo[4,3-c]pyrimidine and Related Compounds1Carroll Temple Jr., Robert L. McKee, and John A. MontgomeryCite this: J. Org. Chem. 1963, 28, 9, 2257–2259Publication Date (Print):September 1, 1963Publication History Published online1 May 2002Published inissue 1 September 1963https://pubs.acs.org/doi/10.1021/jo01044a024https://doi.org/10.1021/jo01044a024research-articleACS PublicationsRequest reuse permissionsArticle Views87Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
GPU Acceleration of Real-time Feature Based Algorithms (2007)

Feature tracking is one of the most fundamental tasks in computer vision, being used as a preliminary step to many high-level algorithms. In general, however, the number of features tracked (leading to more accurate high-level algorithms) must be balanced against the computational requirements of the feature tracking algorithm. To enable a large number of features to be tracked in real time without degrading the computational performance of high-level computer vision algorithms, we offload the feature tracking algorithm to the the video card (GPU) found in modern personal computers. Using the GPU allows for tracking an order of magnitude more features than a pure software-based algorithm, with minimal increase in CPU usage. We have demonstrated the computational benefits of GPU-based feature tracking within a real-time video stabilization application.
An Introduction to Brain-Computer Interfacing (2007)

We provide a compact overview of invasive and noninvasive brain-computer interfaces (BCI). This serves as a high-level introduction to an exciting and active field and sets the scene for the following sections of this book. In particular, the chapter briefly assembles information on recording methods and introduces the physiological signals that are being used in BCI paradigms. Furthermore, we review the spectrum from subject training to machine learning approaches. We expand on clinical and human-machine interface (HMI) applications for BCI and discuss future directions and open challenges in the BCI field.
Thermoelectric generator for heat meter (2002)

This paper introduces a thermoelectric generator that supplies electricity for a heat meter (calorimeter). It is an excellent pollution-free power source produced by utilizing the principle of the Seebeck effect of a special semiconductor, which can generate electricity directly by the hot water inside the heat supply pipes. Inside the generator, there are voltage-stabilizing circuits that can supply stable voltage of direct current. The generator belongs to a solid power source, which can work safely and continuously for long periods without maintenance. Its long-term ratio between the property and price is more advantageous than other usable batteries.
Plug-and-Simulate within Modular Assembly Line enabled by Digital Twins and the use of AutomationML (2017)

The Digital Age is becoming the de-facto of future direction in manufacturing domain. Its main driver is the pressure of shorter product life cycles and leads companies to faster engineering time of their production lines. To cope with the need, recent literature has successfully shown modular production and assembly line concepts by using standardized interfaces on electromechanical and communication level. This change entails new challenges. Given the fact that production life cycle decreases, the usage of tools for digital manufacturing and simulation grow in importance to support and evaluate the impact of increasing engineering and decision-making processes. The concurrent combination of the physical world with its digital counterpart will be crucial. This paper proposes how engineers set up the digital environment automatically by using a common data model inspired by the Digital Twin concept. Its instantiation for several assembly modules based on AutomationML consists of a set of engineering data and relevant models to support a proof-of-concept of Plug-and-Simulate within a modular, multi-vendor assembly line.
Implementation of Packaged Integrated Antenna With Embedded Front End for Bluetooth Applications (2008)

The design, integration and realization of system in enhanced package approach towards fully functional system level integration by using a compact Bluetooth USB dongle as the demonstrator is presented here. The integration was done on FR4 substrates, which is totally compatible with today's printed circuit board manufacturing capability. A commercially available bluetooth integrated chip was chosen as the chipset of our demonstrator, and a package integrated antenna together with an embedded front end completes the system in package integration. The front end developed here is based on an embedded meander line combline filter and an embedded transformer balun. The filter has a 35% area reduction when compared with the classical combline filter and similar performance. The balun has the coils distributed on three layers that minimized the board area needed it and optimizes the performances. The proposed packaged integrated antenna approach is successfully demonstrated here and the new module shows excellent performance when compared with a commercial solution, surpassing the normal Bluetooth class II dongle range which is up to 10 m and increasing the module range up to 120 m without an extra power amplifier.
Glass Wool–H<sub>2</sub>O<sub>2</sub>/CoCl<sub>2</sub> test system for <i>in vitro</i> evaluation of biodegradative stress cracking in polyurethane elastomers (1995)

Environmental stress cracking (ESC) in polyetherurethanes has been demonstrated in animal models. However, duplication of this phenomenon in vitro has been a challenge. The glass wool-H2O2/CoCl2 test system was designed to provide oxidation components found in vivo, i.e., hydroxyl radical (HO.), molecular oxygen (O2), and superoxide (O2-.) required for auto-oxidation of polyetherurethanes. The in vitro test is not only reliable in duplicating the characteristics of in vivo stress cracking in polyetherurethanes at 37 degrees C, but also accelerates ESC as much as seven times. The test results on several types of polyurethanes showed that Tecothane 80A was as vulnerable to biodegradative stress cracking in vitro as Pellethane 2363-80A, while the new generation of polyurethanes, Corethane, demonstrated great resistance against stress cracking.
[Recommendations for treatment of acne vulgaris]. (1993)

Acne vulgaris is by far the most prevalent of adolescent skin disease, involving 60-80% of the teenage population. By androgen-stimulation the production of sebum is increased and by hyperkeratinisation the canal of the pilosebaceous follicle will be closed, thereby causing formation of comedones. These will get infected with Propionibacterium acnes. The treatment of acne vulgaris therefore consists in 4 steps: sebosuppression (with Benzoylperoxid), keratolysis (with Vitamin A-acid and Azelainacid), bakteriostasis and stopping inflammation (with antibiotics). A mild cure of the affected skin is necessary too.
BUS TRAVEL TIME PREDICTION MODEL FOR DYNAMIC OPERATIONS CONTROL AND PASSENGER INFORMATION SYSTEMS (2003)

Automatic Vehicle Location (AVL) and Automatic Passengers Counters (APC) systems have been increasingly implemented by transit agencies for the real time monitoring of transit vehicles and automatic counting of passengers boarding and alighting at bus stops. As a result, a vast amount of potentially online data related to transit operation could be obtained from these systems. The emphasis of this research effort was on using AVL and APC dynamic data to develop a bus travel time model capable of providing real time information on bus arrival times to passengers, via traveler information services and to transit controllers for the application of proactive control strategies. The developed model is based on two Kalman filter algorithms for the prediction of running times and dwell times alternately in an integrated framework. The AVL and APC data used were obtained for a specific bus route in Downtown Toronto. The performance of the developed prediction model was tested using “hold out ” data and other data from microsimulation representing different scenarios of bus operation along the investigated route using the “VISSIM ” microsimulation software package. The Kalman Filter algorithm outperformed all other developed models in terms of accuracy, demonstrating the dynamic ability to update itself based on new data that reflected the changing characteristics of the transit-operating environment.
Monothiolation and Reduction of Graphene Oxide <i>via</i> One-Pot Synthesis: Hybrid Catalyst for Oxygen Reduction (2015)

The functionalization of graphene provides diverse possibilities to improve the handling of graphene and enable further chemical transformation on graphene. Graphene functionalized with mainly heteroatom-based functional groups to enhance its chemical and physical properties is intensively pursued but often resulted in grafting of the heteroatoms as various functional groups. Here, we show that graphene oxide can be functionalized with predominantly a single type of sulfur moiety and reduced simultaneously to form monothiol-functionalized graphene. The thiol-functionalized graphene shows a high electrical conductivity and heterogeneous electron transfer rate. Graphene is also embedded with a trace amount of manganese impurities originating from a prior graphite oxidation process, which facilitates the thiol-functionalized graphene to function as a hybrid electrocatalyst for oxygen reduction reactions in alkaline medium with an onset potential lower than for Pt/C. Further characterizations of the graphene are performed with X-ray photoelectron spectroscopy, scanning electron microscopy with energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, Raman spectroscopy, and electrochemical impedance spectroscopy. This material contributes to the class of hybrids that are highly active electrocatalysts.