gebhart/patrepeval huggingface dataset:
The biochemistry and molecular biology of atrial natriuretic factor (1985)

Research Article| December 01 1985 The biochemistry and molecular biology of atrial natriuretic factor T G Flynn; T G Flynn Search for other works by this author on: This Site PubMed Google Scholar P L Davies P L Davies Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1985) 232 (2): 313–321. https://doi.org/10.1042/bj2320313 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation T G Flynn, P L Davies; The biochemistry and molecular biology of atrial natriuretic factor. Biochem J 1 December 1985; 232 (2): 313–321. doi: https://doi.org/10.1042/bj2320313 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1985 London: The Biochemical Society1985 Article PDF first page preview Close Modal You do not currently have access to this content.
Characterization of scanning probe microscope tips for linewidth measurement (1991)

For accurate linewidth measurement in scanning probe metrology the shape and size of the probe tip must be known. Since the probe can be degraded during a scan, quick in situ characterization is desirable. A technique is described employing an array of known structures that allows tip characterization with the probe microscope itself. This technique can be used to measure either the shape of a probe tip or the flexing caused by attractive forces near a sidewall. The results suggest that the sharpest probes may experience significant bending in the vicinity of a wall.
Preoperative Predictors of Significant Symptomatic Response After 1 Year of Gastric Electrical Stimulation for Gastroparesis (2010)

Abstract Background In cases of gastroparesis where significant symptoms fail to respond to standard medical therapy, gastric electrical stimulation (GES) may be of benefit. Unfortunately, not all patients improve with this therapy. Reliable preoperative predictors of symptomatic response to GES may allow clinicians to offer this expensive and invasive treatment to only those patients most likely to benefit. Methods Therapy was initiated in 15 patients more than 12 months prior to this retrospective review of our prospectively maintained data. All patients completed a Total Symptom Score (TSS) survey at every encounter as well as the SF‐36 quality‐of‐life instrument prior to surgery. A failure of GES therapy was considered to have occurred when after 1 year of treatment, preoperative TSS had not decreased by at least 20%. Results Four patients (4 idiopathic) failed to improve more than 20% on multiple assessments after a year of therapy. All diabetic patients experienced a durable symptomatic improvement with GES. Review of individual items of the TSS revealed that nonresponders experienced less severe vomiting preoperatively. Conclusions Diabetic gastroparesis patients respond best to GES. Responders tend to have more severe vomiting preoperatively. Patients with idiopathic gastroparesis who do not experience severe vomiting should be cautioned about a potentially higher rate of poor response to GES and may be better served with alternative treatments.
Development and mechanical characterization of eugenol–cetalkonium chloride sustained release mucoadhesive oral film (2015)

The aim of this study was to develop and characterize sustained release mucoadhesive films containing eugenol and cetalkonium chloride (HEC) for oral applications. A solvent casting method was used with hydroxypropyl methylcellulose as a film‐forming polymer. Physical and mechanical characterization, mucoadhesion, content uniformity, dissolution, and drug permeation were studied on blank film (HB), film containing eugenol (HE), film containing cetalkonium chloride (HC), and films containing eugenol and cetalkonium chloride (HEC) of different casting weight. The tensile strength, viscosity, and pH of HEC films were found to be significantly lower than those of HB films. HEC films with 30 g of casting weight were thicker than HEC films with 25 g of casting weight and drugs were less uniformly distributed in them. It was observed that 30 g casting weight was preferred for film preparation because of higher drug flux and more sustainable drug availability after a period of dissolution. POLYM. COMPOS., 37:3200–3209, 2016. © 2015 Society of Plastics Engineers
Controlled Microfluidic Encapsulation of Cells, Proteins, and Microbeads in Lipid Vesicles (2006)

Cells have been encapsulated inside lipid vesicles by using a new microfluidic lipid vesicle formulation technique. Lipid vesicles are formulated within minutes without using toxic lipid solvents. The encapsulation efficiency inside the vesicles is controlled by the microfluidic flows. Green fluorescent proteins (GFP), carcinoma cells, and bead encapsulated vesicles have mean diameters of 27.2 mum, 62.4 mum, and 55.9 mum, respectively. The variations of vesicle sizes are approximately 20% for the GFP and cell encapsulated vesicles and approximately 10% for the bead encapsulated vesicles.
The Detection of Incipient Faults in Transmission Cables Using Time Domain Reflectometry Techniques: Technical Challenges (1982)

The location and repair of faults in underground transmission lines is a difficult and time-consuming operation. The Department of Energy has sponsored research in the development of instrumentation to detect and locate incipient fault sites. Some of these methods rely on reflectometry techniques in either the time or frequency domain. NBS has investigated the feasibility of using such methods in extruded polyethylene cables.
Molecular farming of fluorescent virus-based nanoparticles for optical imaging in plants, human cells and mouse models (2014)

The application of plant virus-derived nanostructures in materials science, biomedical research and engineering has recently been promoted by the development of fluorescence-labeled viruses for optical imaging in tissue culture and preclinical animal models. Most studies reported thus far have focused on the application of viruses that have been chemically modified with organic dyes. In this investigation, we sought to develop and study genetically-engineered virus-based biomaterials that incorporate green or red fluorescent proteins. The genetic introduction of such imaging moieties is advantageous because post-harvest modifications are not required, thus minimizing the number of manufacturing steps and maximizing the yields of each fluorescent probe. Specifically, we engineered the filamentous plant virus Potato virus X (PVX) to display green fluorescent protein (GFP) or mCherry as N-terminal coat protein (CP) fusions, producing a 1 : 3 fusion protein to CP ratio. The infection of Nicotiana benthamiana plants with the recombinant GFP-PVX and mCherry-PVX particles was documented by fluorescence imaging, structural analysis and genetic characterization to determine the stability of the chimeras and optimize the molecular farming protocols. We also demonstrated the application of fluorescent mCherry-PVX filaments as probes for optical imaging in human cancer cells and a preclinical mouse model. Cell viability assays and histological analysis following the administration of mCherry-PVX indicated the biocompatibility and rapid tissue clearance of the particles. Such particles could therefore be functionalized with additional cancer-specific detection ligands to provide tools for molecular imaging, allowing the investigation of molecular signatures, disease progression/recurrence and the efficacy of novel therapies.
Some Observations on the Effect of Surface Roughness upon Diffusion (1968)

The effect of surface roughness has been investigated experimentally and found to lead to spuriously high values of the diffusion coefficient. The magnitude of the error has been estimated as a function of Dt and the degree of roughness. The results indicate that surface roughness may contribute the major source of error in the determination of very small diffusion coefficients. The presence of an uneven source surface may also account for the anomalous tracer penetration profiles which are observed in the vicinity of the surface and, corresponding to which, anomalous values of D have been frequently reported.
Magnetic-field sensing with a single-mode fiber (1981)

A fiber-optic magnetic-field sensor is constructed by bonding a single-mode fiber to a nickel cylinder. The magnetic field, by means of the magnetostrictive effect, alters the state of polarization of light in the fiber. A sensitivity of 1.76 x 10(-2) rad/m Oe is demonstrated, permitting detection of fields as small as 4.4 x 10(-6) Oe/m of fiber.
Isotropic non-white matter partial volume effects in constrained spherical deconvolution (2014)

Diffusion-weighted (DW) magnetic resonance imaging (MRI) is a non-invasive imaging method, which can be used to investigate neural tracts in the white matter (WM) of the brain. Significant partial volume effects (PVEs) are present in the DW signal due to relatively large voxel sizes. These PVEs can be caused by both non-WM tissue, such as gray matter (GM) and cerebrospinal fluid (CSF), and by multiple non-parallel WM fiber populations. High angular resolution diffusion imaging (HARDI) methods have been developed to correctly characterize complex WM fiber configurations, but to date, many of the HARDI methods do not account for non-WM PVEs. In this work, we investigated the isotropic PVEs caused by non-WM tissue in WM voxels on fiber orientations extracted with constrained spherical deconvolution (CSD). Experiments were performed on simulated and real DW-MRI data. In particular, simulations were performed to demonstrate the effects of varying the diffusion weightings, signal-to-noise ratios (SNRs), fiber configurations, and tissue fractions. Our results show that the presence of non-WM tissue signal causes a decrease in the precision of the detected fiber orientations and an increase in the detection of false peaks in CSD. We estimated 35-50% of WM voxels to be affected by non-WM PVEs. For HARDI sequences, which typically have a relatively high degree of diffusion weighting, these adverse effects are most pronounced in voxels with GM PVEs. The non-WM PVEs become severe with 50% GM volume for maximum spherical harmonics orders of 8 and below, and already with 25% GM volume for higher orders. In addition, a low diffusion weighting or SNR increases the effects. The non-WM PVEs may cause problems in connectomics, where reliable fiber tracking at the WM-GM interface is especially important. We suggest acquiring data with high diffusion-weighting 2500-3000 s/mm(2), reasonable SNR (~30) and using lower SH orders in GM contaminated regions to minimize the non-WM PVEs in CSD.
CVI.—Elimination of the amino-group of tertiary amino-alcohols. Part III. A new method for the preparation of optically active ketones (1926)

Alex. McKenzie, R. Roger and G. O. Wills, J. Chem. Soc., 1926, 129, 779 DOI: 10.1039/JR9262900779
Downstream plasma characteristics from a single loop antenna in a helicon processing reactor (1999)

The spatial profiles of ion density and wavefields are investigated in a plasma processing reactor using a single loop antenna which couples to the m = 0 mode of a helicon wave in the low magnetic field regime. An increase in ion density away from the antenna is observed. The wavefields of the helicon modes present are seen to be a superposition of higher order radial modes and their reflections from the endplate. It is found that the single loop antenna can generate a plasma with parameters that have the necessary requirements for use as a general processing plasma source.
Rapid detection of Mycobacterium avium in stool samples from AIDS patients by immunomagnetic PCR (1996)

Direct PCR detection of bacteria in clinical samples is often hindered by the presence of compounds that inhibit the PCR. To improve and accelerate the diagnosis of Mycobacterium avium-M. intracellulare complex infections, an immunomagnetic PCR (IM-PCR) assay was developed. This IM-PCR procedure combines the separation of mycobacteria by antimycobacterial monoclonal antibody coupled to magnetic beads with an M. avium-M. intracellulare complex-specific PCR protocol based on 16S rRNA gene sequences. As few as 10 M. avium bacilli were detected in spiked human stool samples, a clinical specimen usually refractory to conventional PCR analysis, by the IM-PCR method. Moreover, M. avium organisms were detected in about 24 h in 18 of 22 culture-confirmed fecal samples from AIDS patients. This IM-PCR protocol should allow for the rapid and sensitive detection of M. avium isolates in clinical specimens.
Preparation by yeast reduction and determination of the sense of chirality of enantiomerically pure ethyl (−)‐4,4,4‐trichloro‐3‐hydroxy‐ and (+)‐4,4,4‐trifluoro‐3‐hydroxybutanoate (1984)

Abstract Reduction of ethyl 4,4,4‐trichloro‐ and 4,4,4‐trifluoro‐3‐oxobutanoate by fermenting baker's yeast ( Saccharomyces cerevisiae ) on a preparative scale (20–50 g in ca . 3 1 of H 2 O) gave 70–80% yields of the trichloro‐ [(−)‐( S )‐ 1a ] and trifluoro‐hydroxyesters [(+)‐( R ) 2a ] of ca . 85 and 45% ee, respectively. Both, (−)‐ 1a and (+)‐ 2a could be obtained in > 98% ee by subsequent crystallization (of(−)‐ 1 , (+)‐ 2a or the 3,5‐dinitrobenzoate (+)‐ 2b . The absolute configuration of both hydroxyesters was determined ( a ) by chemical correlation ((−)‐ 1a ), ( b ) from the melting diagrams and mixed melting points (differential‐scanning calorimetry Fig. 1 ) of the dinitrobenzoates of the CF 3 ‐derivative (+)‐ 2a and its CH 3 ‐analogue 8 , and c ) by X‐ray analysis of the ester 2f from (+)‐ 2a and (−)‐camphanoyl chloride ( Fig. 2 and 3 ).
Poly(methyl methacrylate) model study of optical surface quality after excimer laser photorefractive keratectomy (2001)

Improvements in beam delivery systems seem desirable.
A New Four-Phase Flash Algorithm for Surfactant Flood Simulation (2017)

Abstract In the recent surfactant flood simulations, there have been efforts to consider the well-known effect of oil composition on the surfactant phase behavior. In order to truly take this effect into account, hydrocarbon phase behavior needs to be coupled with the surfactant phase behavior to evaluate more accurate oil composition, especially when gaseous phase could exist in a reservoir during a simulation. Also, there is a strong need to have this coupling in a fully implicit, fully coupled (shortly, FIM) simulator in order to get all the benefits from the FIM numerical solution approach in surfactant flood simulations. In this study, therefore, we propose a new gaseous/oleic/microemulsion/aqueous phase flash algorithm to couple the hydrocarbon phase behavior with the surfactant phase behavior in our FIM simulator using a new set of non-linear solution variables. Instead of using the phase molar fraction which is one of the conventional natural non-linear solution variables in a FIM simulator, we use various concentrations/fractions along with pressure and phase saturation as input for the four phase flash algorithm. The concentrations/fractions are the non-linear solution variables newly introduced to our FIM simulator. With the new algorithm, we can easily consider the cation exchange on surfactant and the indirect effect of volume of surfactant adsorbed on rock in the four phase flash. We need little conversion work and don't need to locally solve equations for concentrations/fractions even if the variables are required. Also we can incorporate the original two-phase hydrocarbon flash and three-phase surfactant flash models into our four phase flash without modification. These are all the advantages over a four phase flash algorithm using the phase molar fraction as input from the non-linear solve. Moreover, as molar fraction of each component is a calculated intermediate input for the new flash algorithm, any simulator using non-linear solution variables related to component moles can easily adopt the algorithm. This actually allows us to implement the same algorithm with slight extension in one of our well and separator models which use the molar non-linear solution variables. We have successfully tested and validated the new four phase flash algorithm using our FIM simulator with both conventional natural and mixed non-linear solution variables. Also, we show the algorithm works well with the effect of cation exchange on surfactant phase behavior. The algorithm has great extensibility to adopt any hydrocarbon and surfactant phase behavior models in our FIM simulator with the mixed non-linear solution variables if the models use their own conventional input and output variable types.
A family of cell-surface glycoproteins defined by a putative anti-endothelial cell receptor antibody in man. (1989)

An efficient immune response depends directly on the ability of lymphocytes and other blood borne leukocytes to leave the blood and enter lymphoid organs and other sites of immune response or inflammation. A new murine mAb termed 515 recognizes a 85- to 90-kDa structure involved in lymphocyte binding to specialized endothelium in postcapillary venules of lymphoid organs (high endothelial venules). In crossed immunoprecipitations followed by SDS-PAGE analysis, 515 appears to be identical to the antilymphocyte homing receptor mAb, Hermes-1. We show here that 515 recognizes peripheral blood leukocytes of all classes examined, but, like Hermes-1, fails to recognize germinal center cells or nearly all cortical (but not medullary) thymocytes. In addition, we demonstrate that 515 recognizes both fibroblasts and epidermal keratinocytes, both in situ and in cultured cell lines. Immunoprecipitation and SDS-PAGE analysis reveals that 515-defined Ag from T lymphocytes, neutrophils, and the epidermal keratinocyte cell line HaCaT are clearly distinct, both before and after treatment with peptide N-glycosidase F, which removes all asparagine-linked oligosaccharides. In contrast, the Mr of 515-defined Ag from T cells and fibroblasts appear indistinguishable. Thus, the 515 mAb recognizes a broadly distributed family of glycoproteins which may be involved in a variety of adhesive functions.
Anhydrous Praseodymium Salts in the Ionic Liquid [bmpyr][Tf<sub>2</sub>N]:  Structural and Optical Properties of [bmpyr]<sub>4</sub>[PrI<sub>6</sub>][Tf<sub>2</sub>N] and [bmyr]<sub>2</sub>[Pr(Tf<sub>2</sub>N)<sub>5</sub>] (2005)

Purposely designed ionic liquids can be excellent solvents for spectroscopic studies of rare earth compounds. Absorption and emission spectra of anhydrous PrI3 and Pr(Tf2N)3 in the ionic liquid 1,1-n-butyl-methylpyrrolidinium bis(trifluoromethanesulfonyl)amide, [bmpyr][Tf2N], at room temperature are presented together with the emission spectra of solid [bmpyr]2[Pr(Tf2N)5] and [bmpyr]4[PrI6][Tf2N]. After excitation into the 3P1 level, remarkable luminescence not only from the 1D2 level but also from the 3P0 and even from the 3P1 level is observed. Amazingly in the case of the solid compounds and even more astonishing for a solution of Pr(Tf2N)3 in [bmpyr][Tf2N] the strongest luminescence transitions start from the 3P0 level. From a solution of PrI3 in [bmpyr][Tf2N] single crystals of [bmpyr]4[PrI6][Tf2N] were grown. The compound crystallizes in the space group P43212 with a = b = 1464.8(2) pm and c = 2846.9(5) pm at 298(2) K and a = b = 1454.52(7) pm and c = 2852.4(2) pm at 170(2) K, respectively. The structure is characterized by [PrI6] octahedra winding along the 43 screw parallel to the crystallographic c axis. Above each octahedral face one 1-butyl-1-methyl-pyrrolidinium cation is tangentially located. The bis(trifluoromethylsulfonyl)amide anions fill the remaining space. From a solution of Pr(Tf2N)3 in [bmpyr][Tf2N] the compound [bmpyr]2[Pr(Tf2N)5] is obtained which crystallizes triclinic, space group P1̄, with a = 12.3217(13) pm, b = 12.4275(14) pm, c = 22.6422(24) pm, α = 94.440(9)°, β = 102.630(8)°, and γ = 105.791(9)°. Here the main structural feature is the separation of the hydrophobic [Pr(Tf2N)5]2- and hydrophilic bmypr+ parts in the structure.
Elimination of limit cycles in digital filters with very low increase in the quantization noise (1977)

In recursive digital filters sustained parasitic oscillations are possible. These limit cycles can be suppressed by "random rounding" such that for any relevant input signal the output signal is superimposed only by an aperiodic quantization noise. The mean power of this unavoidable noise can be reduced by a circuit modification.
ÜNİVERSİTE ÖĞRENCİLERİNE VERİLEN SAĞLIKLI YAŞAM BİÇİMİ DAVRANIŞLARI DERSİNİN ETKİNLİĞİNİN ÖLÇÜLMESİ (2017)

AMAC: Arastirmada universite ogrencilerine verilen saglikli yasam bicimi davranislari dersinin etkinliginin olculmesi amaclanmistir. YONTEM: Arastirma on test-son test ve kontrol gruplu duzende yari deneysel olarak tasarlanmistir. Arastirmada orneklem hesabina gidilmemis universitenin ortak ders havuzundan ders alan ogrencilerden arastirmaya katilmaya gonullu olan ogrenciler (N=86) ornekleme dahil edilmistir. Saglikli Yasam Bicimi Davranislari dersine kayit olan 35 ogrenci calisma diger derse kayit olan 51 ogrenci ise kontrol grubuna dahil edilmistir. Verilerin toplanmasinda arastirmacilar tarafindan hazirlanan “Kisisel Bilgi Formu” ve “Saglikli Yasam Bicimi Davranislari Olcegi II” kullanilmistir. Ogrencilere egitim oncesi formlar uygulanmis ve 12 hafta suren egitimden 2 hafta sonra olcek uygulamasi tekrarlanmistir. BULGULAR: Saglikli Yasam Bicimi Davranislari Olcegi II ve Alt Olcek on test puanlarinda calisma ve kontrol grubu baslangic puanlarinda anlamli farklilik bulunmamistir (p>0,05). Calisma grubu ogrencilerinin olcekten aldiklari on test puanlari ile son test puanlari karsilastirildiginda; egitim sonrasi ogrencilerin saglik sorumlulugu (t=-2,958 p=0,006), fiziksel aktivite (t=-2,323 p=0,026) ve beslenme (t=-5,295 p=0,001) alt boyutlarindan aldiklari puanlarin anlamli derecede yuksek oldugu bulunmustur. Calisma ve kontrol grubu ogrencilerinin son test puanlari karsilastirildiginda; calisma grubu ogrencilerinin beslenme alt boyutundan aldiklari puanlarin anlamli derecede yuksek oldugu bulunmustur (t=3,464 p=0,001). TARTISMA ve SONUC: Saglikli Yasam Bicimi Davranislari Dersi, universite ogrencilerini ozellikle beslenme alaninda olumlu yonde etkiledigi bulunmustur.
Optical waveguide fabrication in neodymium-doped lithium niobate (1988)

We report the realisation of high-quality, proton-exchanged optical waveguide structures in neodymium-doped lithium niobate. Measurements indicate that the presence of the neodymium does not alter the proton exchange rate, and the presence of the protons does not affect the emission and absorption spectra of the bulk material significantly. Such waveguides will permit the realisation of highly efficient semiconductor laser pumped amplifiers and laser structures integrated with electro-optic and/or acousto-optic elements.
An approach to scheduling and allocation using regularity extraction (2002)

The authors propose that an important class of VLSI systems that are characterized by regularity of their descriptions can be efficiently synthesized in a hierarchical fashion. In other words, the regularity can be extracted to abstract the system design, thereby simplifying the complex tasks of behavioral synthesis. Heuristics that extract regularity and explore the design space in a hierarchical fashion are presented and the feasibility of the approach on signal processing systems is demonstrated. Extension of the proposed approach to other synthesis tasks is being investigated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>