gebhart/patrepeval huggingface dataset:
Natural rubber‐latex allergy in patients not intensely exposed (1998)

Immediate-type allergy to natural rubber latex (NRL) is common in highly exposed groups, particularly in health-care workers and patients with spina bifida. The occurrence of NRL allergy was investigated in subjects not belonging to such risk groups. A total of 493 patients presenting with various diseases for allergologic evaluation was studied. A questionnaire-based history was taken, skin prick tests with NRL milk and common aeroallergens were done, and NRL-specific serum IgE antibodies were measured. A total of 317 subjects (64.3%) was atopic. There were skin prick test reactions to NRL in 80 (16.2%) and NRL-specific IgE in the serum in 79 (16.0%) subjects; both were found in 25 patients (5.1%). Altogether, NRL sensitization was found in 134 patients (27.2%). By history and/or challenge tests, 13 subjects (2.6%) were diagnosed as having clinically relevant NRL allergy. In five of these, anaphylactic reactions had occurred during dental procedures, and in four during general anesthesia; 10 subjects reported immediate-type reactions to NRL products in daily life. All patients with clinically relevant NRL allergy had a skin prick test reaction to NRL milk (sensitivity 100%). Nine had specific IgE antibodies in the serum (sensitivity 69.2%); respective specificity was 86.0% or 85.4%. Nine of the 13 patients (69.2%) with NRL allergy were atopic. Despite exclusion of those at risk, many patients had clinically relevant allergy to NRL, and many of these had had severe reactions. NRL allergy is an important health issue also beyond the known risk groups.
ENDOCRINE FACTORS IN ATYPICAL GROWTHS (1942)

In the 1937 Cold Spring Harbor Symposium on hormones the writer discussed “Reactions of genital tissues to estrogens” (Allen, 1937). Growth of genital tissues in response to hormonal stimulation was stressed as the outstanding reaction. The periodic spurts of growth which bring the genital organs to the condition of estrus at the restricted period of mating are entirely dependent on this hormonal stimulation.
Characterization of micromachined cryogenic coolers (2007)

Micro cryogenic coolers can be used to cool small circuitry and improve their performance. The authors present a variety of micro coolers which are fabricated using MEMS technology production processes only. The typical dimension of a micro cold stage is 30 × 2.2 × 0.5 mm. It cools down to 96 K, applying Joule–Thomson expansion in a 300 nm high flow restriction and has a cooling power ranging from 10 mW to 25 mW. This paper discusses the operation of the micro cold stage and the characterization measurements done.
6mer seed toxicity in tumor suppressive microRNAs (2018)

Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions 2-7 of the guide strand). Here we performed an siRNA screen with all 4096 6mer seeds revealing a preference for guanine in positions 1 and 2 and a high overall G or C content in the seed of the most toxic siRNAs for four tested human and mouse cell lines. Toxicity of these siRNAs stems from targeting survival genes with C-rich 3'UTRs. The master tumor suppressor miRNA miR-34a-5p is toxic through such a G-rich 6mer seed and is upregulated in cells subjected to genotoxic stress. An analysis of all mature miRNAs suggests that during evolution most miRNAs evolved to avoid guanine at the 5' end of the 6mer seed sequence of the guide strand. In contrast, for certain tumor-suppressive miRNAs the guide strand contains a G-rich toxic 6mer seed, presumably to eliminate cancer cells.
Structural Health Monitoring of Pipelines for Environment Pollution Mitigation (2015)

Oil and gas infrastructures may be exposed to landslides, earthquakes, corrosion and fatigue, and to damage from thefts or vandalism, leading to leakage and failure with serious economic and ecologic consequences. For this reason, an increasing interest in applied research on monitoring and protecting pipelines (for fuel, oil and natural gas transportation) arises. Aimed at the mitigation of catastrophic effects of human and natural damage, the present paper proposes a smart real-time Structural Health Monitoring (SHM) system capable to control structural integrity continuously, focusing on the issue of spillage for thefts of fuels which are not detectable, in real-time, by the existing monitoring systems. The system consists of a smart-pipeline containing a health monitoring integrated measurement chain, i.e. an enhanced Fiber Bragg Gratings-based fiber optics neural network on the pipes, for displacement and acceleration monitoring (gathering many other different measurements such as: ground motion, permanent ground displacement, pipeline temperature, pipeline deformation, leakage, etc.). Specifically, the ability to measure these characteristics at hundreds of points along a single fiber and the great accuracy of each point of measure, are particularly interesting for the monitoring of structures such as pipelines in order to detect hazardous and unauthorized intrusion and damage.
Fortschritte in der Tumorbehandlung bei Kindern mit Hilfe der Lasertechnik (1994)

Article Fortschritte in der Tumorbehandlung bei Kindern mit Hilfe der Lasertechnik was published on January 1, 1994 in the journal Biomedical Engineering / Biomedizinische Technik (volume 39, issue s1).
Incorporating human and learned domain knowledge into training deep neural networks: A differentiable dose‐volume histogram and adversarial inspired framework for generating Pareto optimal dose distributions in radiation therapy (2019)

The MSE+DVH+ADV model performed the best in these categories, illustrating the importance of both human and learned domain knowledge. Expert human domain-specific knowledge can be the largest driver in the performance improvement, and adversarial learning can be used to further capture nuanced attributes in the data. The real-time prediction capabilities allow for a physician to quickly navigate the tradeoff space for a patient, and produce a dose distribution as a tangible endpoint for the dosimetrist to use for planning. This is expected to considerably reduce the treatment planning time, allowing for clinicians to focus their efforts on the difficult and demanding cases.
Design of event-based Intrusion Detection System on OpenFlow Network (2013)

OpenFlow (OF) Network is a novel network architecture many famous cloud service providers have applied it to build their data center network. The difference between OF Network and traditional network architecture is the decoupling of controller planes and data planes for network management. Intrusion detection is very important in cloud computing to improve system security. Because OF network can improve the response time of an alert by efficiently configuring network flows, we design an event-based Intrusion Detection System (IDS) architecture on OF network.
Efficacy of entomopathogenic fungi against soil‐dwelling life stages of western flower thrips, <i>Frankliniella occidentalis</i>, in plant‐growing media (2008)

Abstract The potential of several entomopathogenic fungi to control soil‐dwelling stages of western flower thrips, Frankliniella occidentalis Pergande (Thysanoptera: Thripidae), was evaluated in various growing media. Two Metarhizium anisopliae (Metsch) Sorokin strains, V275 and ERL700, were the most effective, causing 85–96% mortality of thrips larvae and pupae (as measured by relative adult emergence rates), 11 days after inoculation. Mortality in other M. anisopliae ‐treated media ranged from 51–84%; Beauveria bassiana (Balsamo) Vuillemin strains caused 54–84% mortality, and Paecilomyces fumosoroseus (Wize) 63–75% mortality. In contrast, mortality from the insecticide treatment (fipronil 1 g l −1 medium) was only 15–54%. Metarhizium anisopliae V275 was selected for more in‐depth evaluation under greenhouse conditions. There was no significant difference in M. anisopliae efficacy in growing media whether it was applied as drench (84–93%) or premixed into the medium as dry conidia (85–92%). The use of M. anisopliae with reduced rates of either fipronil or imidacloprid did not significantly improve control. Overall, our study shows that M. anisopliae V275 is robust and offers much promise for the control of soil‐dwelling stages of thrips as part of an integrated pest‐management programme.
Biorthogonal bases of compactly supported wavelets (1992)

Abstract Orthonormal bases of compactly supported wavelet bases correspond to subband coding schemes with exact reconstruction in which the analysis and synthesis filters coincide. We show here that under fairly general conditions, exact reconstruction schemes with synthesis filters different from the analysis filters give rise to two dual Riesz bases of compactly supported wavelets. We give necessary and sufficient conditions for biorthogonality of the corresponding scaling functions, and we present a sufficient conditions for the decay of their Fourier transforms. We study the regularity of these biorthogonal bases. We provide several families of examples, all symmetric (corresponding to “linear phase” filters). In particular we can construct symmetric biorthogonal wavelet bases with arbitraily high preassigned regularity; we also show how to construct symmetric biorthogonal wavelet bases “close” to a (nonsymmetric) orthonormal basis.
Design and Analysis of an Interior Permanent Magnet (IPM) Machine With Very Wide Constant Power Operation Range (2008)

This paper evaluates the design of a new segmented interior permanent magnet (SIPM) machine with very wide constant power operation range. The machine uses segmentation of the rotor magnets with the help of iron bridges between magnet segments. This provides for an inherent flux-weakening capability to the interior permanent magnet (IPM) machine. A very wide flux-weakening range has been achieved by using a standard distributed stator winding only. The flux-weakening capability of the proposed SIPM motor was compared to a conventional IPM machine. The same stator was used in both machines for direct comparison. The paper also presents the design optimization process and experimental verification of the performance of the proposed machine as a case study of a 42 V alternator operation in which the speed range is from 600 to 6000 r/min.
Controlled branching of polyglycidol and formation of protein–glycidol bioconjugates via a graft-from approach with “PEG-like” arms (2013)

The control of the branching in polyglycidols as semibranched alternatives to traditional polyglycidols is presented. The relative abundance of dendritic carbons is lowered by five-fold compared to hyperbranched polyglycidols. It is the first example of tailoring the branching in polyglycidol and creating protein-glycidol bioconjugates as alternatives to pegylated biostructures.
Protective effects of a cyclic nitrone antioxidant in animal models of endotoxic shock and chronic bacteremia. (1994)

Evidence of a role for oxygen-derived free radicals in the pathophysiology of endotoxic shock has been found in animal models. However, the importance of free radicals in chronic models of bacterial infection has not been examined. In this study a novel nitrone radical spin trap is described and its activity in animal models of endotoxic shock and chronic bacteremia were explored. MDL 101,002 is a cyclized variant of alpha-phenyl N-tert-butyl nitrone (PBN), an established spin trap. MDL 101,002 can react with free radicals to form persistent adducts as demonstrated by electron paramagnetic resonance (EPR) spectroscopy. This agent is about 10 times more potent than PBN as an in vitro antioxidant and scavenger of hydroxyl radicals. In a rat endotoxic shock model MDL 101,002 (3-30 mg/kg, i.p.) administered 30 min prior to endotoxin (30 mg/kg, i.p.) treatment reduced mortality in a dose-dependent manner. Peroxide-enhanced chemiluminescence in hepatic homogenates from endotoxin treated rats was elevated indicating that oxidative stress and antioxidant depletion was increased. Importantly, treatment with MDL 101,002 (30 mg/kg, i.p.) 30 min prior to, and 120 min following endotoxin, minimized the increase in chemiluminescence. MDL 101,002 also reduced mortality in a model of chronic bacteremia employing implantation of infected fibrin clots into the peritoneal cavity of gentamicin-treated leukopenic rats. MDL 101,002 (2.5 mg/kg/hr) increased survival from 24% to 52% in these rats. These data are consistent with a role for free radicals in the pathophysiology of endotoxic shock and suggest free radicals are also important mediators in chronic models of sepsis.
Dipole Interaction-Controlled Stereoselectivity in Aldol Reaction of α-CF<sub>3</sub> Enolate with Fluoral (2003)

The stereoselectivity of a reaction is generally determined by minimizing steric repulsion. However, the aldol reaction of alpha-CF(3)-ketone (Z)-enolate with fluoral anomalously gave an anti-aldol through a sterically demanding transition state, because of the strong dipole interaction of the two CF(3) groups. We have thus disclosed a paradigm shift from steric to electronic control of reaction stereoselectivity. [reaction: see text]
Error detection for fast Toeplitz eigensolvers (1996)

Several authors have proposed fast methods for Toeplitz eigendecomposition based on fast Yule-Walker solvers. The most efficient of these fast methods are numerically unstable. This work presents an efficient test to detect errors resulting from instability and ensure the accuracy of eigenvalues and eigenvectors computed using fast methods.
THE EFFECTS OF ORAL AH 5158, A COMBINED α AND β‐ADRENOCEPTOR ANTAGONIST, IN HEALTHY VOLUNTEERS (1974)

1 In healthy male volunteers after single oral doses, AH 5158 produced inhibition of exercise induced tachycardia, falls in systolic and diastolic pressure at rest and in response to exercise, which are probably related to combined β- and α-adrenoceptor antagonism. 2 At increasing doses from 100 mg to 400 mg there exists a dose related antagonistic effect, though the dominant effect of β-adrenoceptor antagonism is more easily demonstrable than is α antagonism. 3 As indicated by the pattern of pharmacological effects, absorption of the oral drug is good and the duration of action of a 400 mg dose is approximately 8 hours. 4 Despite being administered in β-adrenoceptor blocking doses, AH 5158 had no adverse effects upon peak expiratory flow at rest or in response to exercise. 5 It is concluded that the pharmacological profile of this combined α- and β-adrenoceptor antagonism suggests a potential therapeutic role as an antihypertensive drug.
A fixed-point DSP for graphics engines (1989)

The use of the 16-bit ADSP-2100 digital signal microprocessor as a fixed-point, low-end graphics engine for applications such as video games and small computer graphics packages is examined. It serves as the basis for a complete, hardware-oriented approach to performing graphics operations on a 3-D database. Normalization and formatting are performed to avoid overflow and preserve data formats through the transformation operation. Data structures that facilitate object rendering through the Bresenham line-segment drawing algorithm are used. A 3*3 rotation matrix is derived for this application, and the means for implementing translation, scaling, perspective, and zooming are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modificaciones fisarias en la rata tras enclavijamiento: estudio comparativo entre implantes plásticos y metálicos (1991)

Resumen.— El presente trabajo se efectuo para estudiar las modificaciones locales indu­ cidas por implantes que atraviesan el cartilago de crecimiento. Se utilizaron 20 ratas macho de 5 semanas de edad. A traves de una incision parapatelar externa se inserto una aguja de Kirschner en el femur derecho y una de plastico en el izquierdo, ambas de 1 mm de diametro, atravesando la placa fisaria distal. Cinco animales por grupo fueron sacrificados al cabo de 1,2,8 y 16 semanas. Tras denudar los femures de partes blandas, su extremidad distal fue procesada para estudio histologico, histomorfometrico e histoquimico. Los resultados demuestran que desde la segunda semana la fisis tuvo mayor altura en los femures con implante metalico, aunque las diferencias no fueron estadisticamente significati­ vas. No se apreciaron diferencias histologicas remarcables entre las placas fisarias con uno u otro implante a lo largo del estudio. La captacion de azul alcian fue asimismo similar, salvo en la decimosexta semana en que fue marcadamente menor alrededor de los implantes metalicos. Se concluye que la naturaleza del implante condiciona las modificaciones fisarias inducida por este. Descriptores: Cartilago crecimiento. Fisis. Epifisiodesis. Osteosintesis. Summary.— A study is made of the local changes induced by implants transversing growth cartilage. Twenty 5-week-old rats were used. A Kirschner needle 1 mm. of diameter was introduced through an external parapatellar incision into the right femur, while a plastic needle of the same dimensions was passed into the left femur. Both needles were advanced until the distal physeal plates were pierced. The rats were sacrificed in groups of 5 after 1,2,8 and 16 weeks. After soft tissue removal, the distal femoral ends were processed for histological, histomorphometri c and histochemical study. After the second week the physeal portions were taller in the femurs that received metal implants, although the differences were not statistically significant. No important histological differences were noted between the physeal plates corres­ ponding to either implant during the study; alcian blue uptake was likewise similar, with the sole exception of the 16th week, during which uptake was markedly less intense around the metal implants. To conclude, implant type is seen to condition the physeal changes induced.
Altered Nuclear Activation Parameters of Rat Sperm Treated <i>in Vitro</i> with Chromatin-Damaging Agents (1998)

Standard semen measures do not assess the genetic integrity of sperm. A human sperm activation assay (HSAA) has proven very useful for assessing sperm quality and predicting pregnancy outcome. The HSAA involves incubating permeabilized sperm in cytoplasmic extracts of Xenopus laevis frog eggs. The extracts activate sperm nuclei, which undergo chromatin decondensation, DNA synthesis, and chromatin recondensation, mimicking events that occur after fertilization in vivo. However, no animal model sperm activation assay has been reported. We hypothesize that sperm activation assays will be useful for studying molecular mechanisms of sperm DNA repair by egg cytoplasm and for screening sperm for damaged DNA. Thus, the objectives of this study were to develop an in vitro rat sperm activation assay (RSAA) using cytoplasmic extracts of X. laevis frog eggs and to determine how chemically damaging the sperm chromatin would affect two sperm activation parameters, chromatin decondensation and DNA synthesis. We incubated demembranated rat sperm in a cytoplasmic extract of X. laevis frog eggs supplemented with tritiated thymidine triphosphate ([3H]TTP). The activated sperm nuclei underwent chromatin decondensation and DNA synthesis. Decondensation kinetics were examined using image analysis to measure the size of the sperm nuclei as they decondensed. DNA synthesis kinetics were examined using autoradiography of incorporated [3H]TTP. To investigate how chemical damage affects nuclear activation, we treated rat sperm in vitro with ethylene glycolbis(sulfosuccinimidylsuccinate; SEGS), a reversible crosslinking agent, or hydroxylamine (HA), a DNA base modifier. Treatment with SEGS blocked decondensation in a dose-dependent manner. In contrast, treatment with HA enhanced decondensation, induced gross chromatin abnormalities, and increased [3H]TTP incorporation into activated sperm nuclei, responses consistent with an attempt by the egg cytoplasm to repair DNA damage. These results suggest that the RSAA may be useful for detecting damaged sperm chromatin as a result of toxicant exposure.
Computer assisted medical interventions (1995)

Many medical or surgical interventions can benefit from the use of computers. Through progress of technology and growing consciousness of the possibilities of real clinical improvements with computers, what was in the past the privilege of very few operations (mostly stereotactic neurosurgery) is now entering many surgical specialities. Although many technical issues remain to be solved, there is virtually no limit to the introduction of computers and robots in any surgical speciality. This tendency can take on the most varied forms. At the authors' institute, three golden rules have guided the computer assisted medical interventions (CAMI) project for about ten years: 1) conceive systems for which the clinical value is well defined; 2) develop generic tools that can be applied to many different clinical applications; and 3) provide efficient collaboration between the surgeon and the system through simple interfaces.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effect of valine and the herbicide sulfometuron methyl on acetolactate synthase activity in nuclear and plasmid-borne sulphometuron methyl resistant <i>Saccharomyces cerevisiae</i> strains (1988)

Acetolactate synthase (ALS) specific activity was evaluated in isogenic lines of Saccharomyces cerevisiae carrying the wild-type ILV2 gene or mutations in this gene for resistance to the herbicide sulfometuron methyl (SM). Statistical comparisons were made between two nuclear alleles and among five alleles borne on a YE chimaeric plasmid transformed into a strain carrying a 1.5-kilobase deletion in the nuclear ILV2 gene. Decreased ALS activity of plasmid-borne SM-resistant mutations was shown not to be caused by copy number effects. ALS-specific activity in strains carrying the wild-type ILV2 allele exhibited strong feedback inhibition by valine and was sensitive to SM. All nuclear and plasmid-borne SM-resistance alleles resulted in ALS-specific activity highly resistant to SM and resistant to valine feedback inhibition.
A Semantic Information Retrieval Technique and an Evaluation for a Narrow Display Based on an Association Mechanism (2007)

The purpose of this study is to output information which users hope as high ranking results on narrow display of mobile information terminals. The concept of the proposed algorithm is to understand the meanings and the contents expressed by keywords and to retrieve appropriately related information. Concretely, we propose an information retrieval technique to evaluate the relationships between words using an association mechanism. A new test collection was made by 100 examinees who judged the retrieval results according to text meanings. Retrieval performance was objectively confirmed with the experiment based on the test collection.