gebhart/patrepeval huggingface dataset:
Pregnancy and lactation after breast‐conserving therapy for early stage breast cancer (1994)

Successful breast-feeding from the untreated, as well as the treated breast, is possible after conservative surgery and radiation. Implications for patients of child-bearing age undergoing conservative surgery and radiation therapy are discussed.
Flight Control System Modeling with SysML to Support Validation, Qualification and Certification (2016)

International audience
Optical properties and application of uranium-based thin films for the extreme ultraviolet and soft x-ray region (2004)

Uranium oxide and uranium nitride thin films reflect significantly more than all previously known/standard reflectors (e.g., nickel, gold, and iridium) for most of the 4-10 nm range at low angles of incidence. This work includes measurements of the EUV/soft x-ray (2-20 nm) reflectance of uranium-based thin films (~20 nm thick) and extraction of their optical constants (δ and β). We report the reflectances at 5, 10, and 15 degrees grazing incidence of air-oxidized sputtered uranium, reactively sputtered (O2) uranium oxide, and reactively sputtered (N2) uranium nitride thin films measured at Beamline 6.3.2 at the Advanced Light Source (ALS) at Lawrence Berkeley National Laboratory (LBNL). Additionally, we report optical constants of reactively sputtered uranium oxide at nine wavelengths from 4.6 to 17.5 nm derived from ALS angle-scan reflectance measurements. We also report optical constants of uranium nitride at 13 and 14 nm. We compare the reflectance of these uranium-compound thin films to gold, nickel (and nickel oxide), and iridium thin films from 2.5 to 11.6 nm. These metal thin films were chosen for comparison due to their wide use in EUV/soft x-ray applications as low-angle, thin-film reflectors. The uranium compounds can exhibit some surface oxidation in ambient air. There are important discrepancies between UO2’s and UN’s actual thin-film reflectance with those predicted from tabulated optical constants of the elemental constituents of the compounds. These differences are also demonstrated in the optical constants we report. Uranium-based optics applications have important advantages for zone plates, thin-film reflectors, and filters.
ESD induced programming of NEPROM cells beyond the I/O protection structures (1995)

In spite of the use of robust I/O protection structures, ESD damage can still occur beyond the protection circuits. In the EPROM products, the damage occurs inside the chip on the NEPROM`s (Non-Erasable PROM) used in the redundancy and Sense Amplifier Delay (SAD) circuits. During an ESD event, charge can be injected into these NEPROM`s and partially program the NEPROM. This failure can only be detected by a change in Icc standby current (Iccsb) and sometimes the data content in the NEPROM`s. To fix this problem, the channel length of the NEPROM cell is increased by 0.2 {micro}m and the HBM ESD level is improved to be above 2000V.
Follicle detection in ultrasound images of ovaries using active contours method (2010)

Knowledge about the status of the female reproductive system is important for fertility problems and age related family planning. The volume of these fertility requests in our emancipated society is steadily increasing. Transvaginal ultrasound imaging of the follicles in the ovary gives important information about the ovarian aging, i.e., number of follicles, size, position and response to hormonal stimulation. Manual analysis of many follicles is laborious and error-prone. In this paper, a new method for recognition of follicles in ultrasound images of ovaries is proposed. This fully automated segmentation method is based on active contours without edge method. The proposed technique is tested on ultrasonographic images of ovaries. The experimental results are compared with inferences drawn by medical expert and demonstrate the efficacy of the method.
Differential Retinoic Acid Signaling in Tumors of Long- and Short-term Glioblastoma Survivors (2011)

Although the prognosis of most glioblastoma patients is poor, 3%-5% patients show long-term survival of 36 months or longer after diagnosis. To study the differences in activation of biochemical pathways, we performed mRNA and protein expression analyses of primary glioblastoma tissues from 11 long-term survivors (LTS; overall survival ≥ 36 months) and 12 short-term survivors (STS; overall survival ≤ 6 months). The mRNA expression ratio of the retinoic acid transporters fatty acid-binding protein 5 (FABP5) and cellular retinoic acid-binding protein 2 (CRABP2), which regulate the differential delivery of retinoic acid to either antioncogenic retinoic acid receptors or prooncogenic nuclear receptor peroxisome proliferator-activated receptor delta, was statistically significantly higher in the tumor tissues of STS than those of LTS (median ratio in STS tumors = 3.64, 10th-90th percentile = 1.43-4.54 vs median ratio in LTS tumors = 1.42, 10th-90th percentile = -0.98 to 2.59; P < .001). High FABP5 protein expression in STS tumors was associated with highly proliferating tumor cells and activation of 3-phosphoinositide-dependent protein kinase-1 and v-akt murine thymoma viral oncogene homolog. The data suggest that retinoic acid signaling activates different targets in glioblastomas from LTS and STS. All statistical tests were two-sided.
On performance evaluation of cooperative spectrum sensing in cognitive radio networks (2010)

This paper presents the system level performance evaluation for energy-detection based cooperative spectrum sensing in cognitive radio networks. Three performance criteria are quantitively analyzed for cooperative spectrum sensing. First, the average error probability is determined given fixed amplifier gains for a fixed number of secondary users by considering all possible channel realizations. Second, the asymptotic error probability is computed in a power constrained cognitive radio network when the number of secondary user approaches infinity. Third, the outage probability is examined when instantaneous error probability is greater than a predefined threshold. In all three calculations, both additive white Gaussian noise (AWGN) and Rayleigh fading assumptions are used to capture the observation and fusion channels. Numerical results indicate that in order to maintain a desired detection performance in low and moderate fusion signal to noise ratio (SNR) regimes, fusion channels need to be as reliable as possible, while local received SNRs can be dynamic and provide spatial diversity. Moreover, it is shown that under AWGN observation channels and Rayleigh fading fusion channels, a diversity order equal to the number of secondary users can be achieved.
High-Accuracy Wireless Traffic Prediction: A GP-Based Machine Learning Approach (2017)

Wireless traffic prediction can effectively reduce the uncertainty in network demand and supply, and thus is a key enabler of smart management in next-generation wireless networks. To the best of our knowledge, this paper is the first to establish a wireless traffic prediction model by applying the Gaussian Process (GP) method based on real 4G traffic data. Our work is two-fold: First, based on the observed wireless traffic patterns, the kernel in our proposed GP model is designed accordingly to capture both the periodic trend and dynamic deviations; second, by leveraging the Toeplitz structure in the covariance matrix, the computational complexity of hyperparameter learning is significantly reduced from O(n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) to O(n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) and that of inference is reduced from O(n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) to O(n \log n), without any loss of prediction accuracy. Experimental results show that the proposed GP model can attain up to 97% prediction accuracy, and outperform the state-of-the-art algorithms considerably.
Nanotechnology advances in controlled drug delivery systems (2008)

Abstract Nanotechnology advances in drug delivery deal with the development of synthetic nanometer sized targeted delivery systems for therapeutic agents of increased complexity, and biologically active drug products. Therapeutic systems in this class are up to a million times larger than classical drugs like aspirin. Being larger there is more scope for diversity and complexity, which makes their protection much more challenging and their delivery more difficult. Their increased complexity however, gives these systems the unique power to tackle more challenging diseases. Targeted delivery systems can have multiple functions, a key one being their ability to recognize specific molecules which can be located either on the membrane of target cells, or in specific compartments within the cell. A challenging objective of targeted drug delivery is the development of innovative multidisciplinary approaches for the design, synthesis and functionalization of novel nanocarriers for targeted delivery of protein/peptide (P/P) drugs via oral, pulmonary and nasal administration routes as well as the fabrication of “smart” miniaturized drug delivery devices able to release a variety of drugs on demand. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Wide field-of-view lensless fluorescence imaging device with hybrid bandpass emission filter (2019)

We demonstrate a highly sensitive lensless fluorescence imaging device with a wide field-of-view by using a hybrid bandpass filter composed of interference filters, an absorption filter, and a fiber optic plate. The hybrid filter shows high excitation light rejection characteristics even in a lensless setup. In this study, we fabricated a hybrid bandpass filter and improved fluorescence observation performance for a target with auto-fluorescence. The filter was combined with a large image sensor with an imaging area of 67 mm2. As a demonstration, a brain slice from a green fluorescent protein transgenic mouse was observed and fluorescent cell bodies were detected with the lensless imaging device.
Equine protozoal myeloencephalitis: a report of two cases from Western Canada. (1981)

Two cases of nonsuppurative myeloencephalitis are reported which clinically and pathologically resemble equine protozoal myeloencephalitis. Lesions in both horses were associated with Toxoplasma-like organisms visible in microscopic sections. Clinical signs and lesions in one case primarily involved the brain and in the other case principally involved the spinal cord and associated meninges. Positive identification of the organisms was not achieved; however, the etiological agent is unlikely to be a species of Toxoplasma. Recently published studies suggest a species of Sarcocystis is involved.
D2 Channel Bank: Per-Channel Equipment (1972)

Traditionally, the design of switching machines has assumed that the transmission plant consists of physical wire pairs. Therefore, appropriate interface equipment is necessary when a multiplex transmission system is substituted for wire pairs. This interface, or per-channel, equipment performs such functions as (i) 2-wire to 4-wire conversion to separate the two directions of transmission, (ii) detection of signaling and supervision information, and (iii) band-limiting and level compensation of the signal prior to sampling. Since failures of the multiplex system can cause massive service interruptions and tie up switching equipment, provision is made to detect such failures and alert the switching machine. Design of per-channel equipment is complicated by the number of options required to account for the large variety of ways in which switching machines utilize wire-pair plant. This article describes the per-channel equipment of the D2 Channel Bank and some of the considerations that went into its design.
Prenatal vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: A combined analysis of two randomized controlled trials (2017)

COPSAC2010: ClinicalTrials.gov NCT00856947; VDAART: ClinicalTrials.gov NCT00920621.
ChemInform Abstract: Tantalum‐Based Encapsulants For Thermal Annealing of GaAs. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Air-Gap Probe Evaluation of Thin Quartz Plates (1981)

Summary The electrical response of a small air-gap probe placed over a convex ATrcut quartz plate is analyzed as a function of frequency and of probe location. It is shown that the response is directly deriveable from Tiersten and Smythe's analysis' of a fully electroded convex quartz plate. A model is derived which allows for identification of the (rotated) x and z crystallographic axes, and measurement of the radius of curvature and location of the thickest point of the crystal plate. Experimental results are shown which demonstrate the validity of the model. An automated system is described which characterizes crystal plates in terms of radius of curvature and location of the thickest part of the plate. This system basically consists of an automatic network analyzer and a motor-driven-stage scanning air-gap probe which operates under network analyzer control. Sample data demonstrating the repeatability and accuracy of this system is presented.
RNAi Therapeutics in Autoimmune Disease (2013)

Since the discovery of RNA interference (RNAi), excitement has grown over its potential therapeutic uses. Targeting RNAi pathways provides a powerful tool to change biological processes post-transcriptionally in various health conditions such as cancer or autoimmune diseases. Optimum design of shRNA, siRNA, and miRNA enhances stability and specificity of RNAi-based approaches whereas it has to reduce or prevent undesirable immune responses or off-target effects. Recent advances in understanding pathogenesis of autoimmune diseases have allowed application of these tools in vitro as well as in vivo with some degree of success. Further research on the design and delivery of effectors of RNAi pathway and underlying molecular basis of RNAi would warrant practical use of RNAi-based therapeutics in human applications. This review will focus on the approaches used for current therapeutics and their applications in autoimmune diseases, including rheumatoid arthritis and Sjögren's syndrome.
Acceptance-angle measurement of multimode fibers: a comparison of techniques (1982)

A number of techniques for measuring multimode fiber acceptance angle are described, and the general requirements and problems particular to each technique are discussed. An experimental comparison is presented of a fiber acceptance-angle technique and a fiber radiation-angle technique. Results are presented on quasi-step index and also plastic-clad silica fibers. It is concluded that the radiation-angle technique offers simplicity of operation with unambiguous results and may, therefore, be a suitable standard method for testing optical fibers.
Deep Subsurface Raman Spectroscopy of Turbid Media by a Defocused Collection System (2007)

A simple procedure for the recovery of deep subsurface Raman spectra in stratified turbid samples by defocusing a conventional Raman instrument is presented. The method is based on effects present with spatially offset Raman spectroscopy (SORS) and, although not as efficient as the standard SORS approach, it permits a simple way of recovering subsurface Raman spectra from less challenging samples. Demonstration of the effect is performed using a standard SORS device and a commercial Raman instrument on the noninvasive measurement of paracetamol tablets held within a nontransparent white plastic bottle.
<i>Science Translational Medicine</i> Podcast: 2 February 2011 (2011)

A conversation with Shannon Dahl about how to bioengineer off-the-shelf vascular grafts for use in surgical transplantation.
The Correction of Aniseikonia with Ophthalmic Lenses (1936)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Kenneth N. Ogle, "The Correction of Aniseikonia with Ophthalmic Lenses," J. Opt. Soc. Am. 26, 323-337 (1936) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
<title>Template-based synchronized multimedia integration language authoring tool</title> (1999)

Synchronized Multimedia Integration Language (SMIL) is a recommendation developed by the W3C Synchronized Multimedia Working Group. SMIL is a declarative authoring language to specify multimedia synchronized presentation using a time line. We present the design and implementation of a domain specific SMIL Authoring Tool (SAT). The output generate from SAT adheres to the standard as the presentation is specified in a human-readable and machine-friendly XML-tagged file. SAT can be use din conjunction with any SMIL-compliant players. It provides a high-level point-and-click tool, which can create and update the logics of SMIL presentations. It is also designed to provide template-based authoring, which is deemed to be easy-to-create for domain- specific presentations.
<title>Performance of a neutron-sensitive scintillating glass fiber panel for portal, freight, and vehicle monitoring</title> (1999)

Neutron-sensitive scintillating glass fiber sensors provide several advantages over <SUP>3</SUP>He and BF<SUB>3</SUB> gas-tubes for plutonium detection and surveillance. Large active areas provide significant improvements in sensitivity versus cost. In addition, the glass sensors offer a wide dynamic counting range, fast response time, and low microphonic susceptibility relative to conventional sensors. We report the results of detection limits for neutron glass panels used for portal, freight and vehicle monitoring.
Effects of porosity on dielectric and piezoelectric properties of porous lead zirconate titanate ceramics (2011)

We report porous lead zirconate titanate ceramics fabricated by tert-butyl alcohol-based gel-casting process which show a very high thickness electromechanical coupling coefficient (0.77), high hydrostatic figure of merit (9594×10−15 m2/N), and low acoustic impedance (3.7 Mrayls). We show that the porosity effectively affects the performance of the samples in two ways: (1) a higher porosity simplifies the resonance behavior, leading to more efficient energy transduction; (2) its replacement of active ceramic phase leads to low relative permittivity, high hydrostatic figure of merit, and low acoustic impedance. It was confirmed the properties could be tailored by controlling the porosity.
Antioxidant Activity of Corn Bran Cell-Wall Fragments in the LDL Oxidation System (1997)

The antioxidant activity of feruloyl arabinose, a model substance of cereal cell-wall fragments, in the LDL autoxidation system by CuSO4 and its absorption were studied. Ferulic acid added as free acid showed little suppressive effect on LDL oxidation. However, ferulic acid sugar esters showed a positive effect. This fact indicated that affinity of LDL particle and free or bound ferulic acid is important for the suppressive effect. The HPLC analysis showed that in rats administered feruloyl arabinose, two peaks were detected with retention times lower than those of feruloyl arabinose and ferulic acid, which appeared upon β-glucuronidase/sulfatase treatment. The study showed that the absorbed form of FAA could be a more polar compound, possibly a conjugated form. Keywords: Antioxidant; low-density lipoprotein; cereal cell wall; ferulic acid sugar ester
Polymer–clay nanocomposites: an overview with emphasis on interaction mechanisms (2004)

There has been a surge of interest in polymer–clay nanocomposites over the past decade. This review surveys these new materials with emphasis on the debate surrounding interaction mechanisms and the behaviour of intercalated polymer in clay galleries. Swelling properties, high cation exchange capacities, high aspect ratio and large surface area give smectite clays the new role of high performance filler for thermoplastic or thermosetting polymers for the creation of intercalated or exfoliated nanocomposites. These nanocomposites can be prepared by three routes: in situ polymerisation, solution methods, or melt processing. Modification of either clay or polymer can change the type of polymer–clay composite. X-ray diffraction and transmission electron microscopy are often employed as the main characterisation techniques to establish the state of the clay. A very low volume fraction of clay significantly improves the mechanical and barrier properties of the pristine polymer, which makes these nanocomposites very promising materials.
YH25448, a 3rd generation EGFR-TKI, in patients with EGFR-TKI-resistant NSCLC: Phase I/II study results. (2018)

9033 Background: The epidermal growth factor receptor (EGFR) T790M mutation is one of the most common acquired resistance mechanism to EGFR tyrosine kinase inhibitors (TKIs). YH25448 is an oral, potent, irreversible EGFR TKI that is highly selective for activating (EGFRm) and T790M resistance mutations. Methods: Patients with EGFRm advanced NSCLC with acquired resistance to EGFR-TKIs with or without asymptomatic brain metastases were enrolled in an open-label, multicenter, phase I/II study with dose escalation and expansion cohorts. YH25448 was administered once daily at doses of 20 to 240 mg in a 21 day cycle. Patients were assessed for safety, tolerability, pharmacokinetics and efficacy. T790M status was confirmed in the expansion cohorts. Results: A total of 105 patients (median age 62 years, female 61%) were enrolled. The dose escalation cohort included 33 patients administered with 20 to 240 mg once daily across 6 dose levels, and 72 patients in the dose expansion cohort were administered with 40 to 240 mg. No dose-limiting toxicities were observed. The most common treatment-emergent adverse events (AEs) were pruritus (12%), decreased appetite (11%), rash (11%), and constipation (10%). AEs of grade 3 or higher were observed in 5% of the patients. Systemic exposure increased dose-dependently. Of the evaluable patients (n = 91) at data cut-off, the objective response rate (ORR) was 64% (95% confidence interval [CI], 53.0 to 73.6). The ORR for 76 of the T790M-positive patients was 67% (95% CI, 55.4 to 77.5), and for 15 of the T790M-negative patients was 47% (95% CI, 21.3 to 73.4). In patients with brain metastases (n = 9), the overall intracranial ORR was 56% (95% CI, 21.2 to 86.3). Conclusions: YH25448 was well tolerated and exhibits promising systemic and intracranial antitumor activity at multiple dose levels in EGFR T790M+ NSCLC patients. Clinical trial identifier: NCT03046992. ORR in T790M+ patients. Dose, QD 20 mg 40 mg 80 mg 120 mg 160 mg 240 mg Evaluable patients*, n 2 25 18 21 8 2 ORR, n (%) 2 (100) 17 (68) 11 (61) 15 (71) 4 (50) 2 (100) *Patients are evaluable for response if they have post-baseline radiological assessment (RECIST 1.1) or patients who discontinued prior to the post-baseline assessment.
Car2X-communication for vision-based object detection (2010)

In this paper, we describe an effective version of an integrated system that combines vision-based object detection and vehicular ad-hoc networks (VANETs). With introduction of VANET in future years, data exchange between vehicles and infrastructure units will be possible and increase safety on roads. The number of vision-based active safety systems, like pedestrian detection and traffic sign recognition, is constantly growing and a hot topic in research. The current project Active Safety Car combines vision-based object detection and VANET communication techniques to achieve improved detection results and to overcome current problems in urban scenarios. We present fundamentals of object detection to illustrate different requirements for a communication system that has to transmit various types of data and describe the implemented system with further details.