gebhart/patrepeval huggingface dataset:
Lacosamide: An investigational drug for adjunctive treatment ofpartial-onset seizures (2008)

Lacosamide, (R)-2-acetamido-N-benzyl-3-meth- oxypropionamide, is a new chemical entity specifically synthesized as an anticonvulsive drug candidate, which appears to have a novel dual mode of action. Its pharmacokinetic characteristics have been studied in young and elderly healthy adults, as well as in adults with epilepsy or diabetic neuropathic pain. After oral administration, lacosamide is rapidly and completely absorbed. An elimination half-life of 13 hours allows for twice-daily dosing. Lacosamide has a low potential for drug-drug interactions. Both oral and intravenous formulations of lacosamide are being developed. In completed placebo-controlled clinical trials, lacosamide has demonstrated efficacy as adjunctive therapy for reduction of seizure frequency in patients with uncontrolled partial-onset seizures, and has been generally well tolerated. For patients treated with lacosamide, the most frequently reported adverse events in placebo-controlled trials include dizziness, headache, nausea and diplopia. When used as short-term replacement for oral lacosamide, intravenous lacosamide has a comparable safety profile to oral lacosamide. Results from clinical trials to date suggest that lacosamide may be a useful pharmacological treatment option for patients with partial-onset seizures.
On the origin and spread of beta-thalassemia: recurrent observation of four mutations in different ethnic groups. (1986)

Seven beta-thalassemia genes were characterized after they were identified as candidates for previously undescribed mutations based upon the close association of DNA polymorphism haplotypes in the beta-globin gene cluster with specific ethnic mutations. The molecular defect in four of these genes was identical, a frameshift deletion of four nucleotides (-CTTT) within codons 41 and 42. This gene represents a common Southeast Asian mutation shared by a Laotian beta-thalassemia gene, [framework 1 (FR1)], a Vietnamese (FR1), and two Chinese patients (FR3 Asian and FR1). The deletion has been observed previously in Chinese (FR1) and Asian Indians (FR2) and is an example of independent origins of the same molecular defect, possible interallelic gene conversion (as it is seen on two different beta-globin gene frameworks in Chinese), and mutant gene migration in the Asian countries. A second example of mutant gene migration was identified in an Iranian patient with a nucleotide insertion (G) between codons 8 and 9, the same mutation previously found in an Asian Indian in the same chromosomal background. The last two genes examined represent further strong evidence for independent origins of mutation. A C-to-T substitution at position -88 in an Asian Indian has been identified previously in an American Black on a different beta-globin gene framework, and a G-to-A transition at nucleotide 1 of intervening sequence 2 found in an American Black has been observed previously on a different chromosome background in Mediterraneans. This study suggests that there are not many common beta-thalassemia mutations remaining to be discovered. It also suggests that certain sequences in the beta-globin gene are relatively mutation sensitive.
Lifestyle Stories: Correlating User Information through a Story-Inspired Paradigm (2013)

Lifestyle management area has been developing over the past years due to an increasing individual and societal need for self-awareness. Technologies play an essential role as they can capture, interpret, and visualize various aspects of users' lives. One of the challenges introduced by capturing lar
Mesh-based 3D textured urban mapping (2017)

In the era of autonomous driving, urban mapping represents a core step to let vehicles interact with the urban context. Successful mapping algorithms have been proposed in the last decade building the map leveraging on data from a single sensor. The focus of the system presented in this paper is twofold: the joint estimation of a 3D map from lidar data and images, based on a 3D mesh, and its texturing. Indeed, even if most surveying vehicles for mapping are endowed by cameras and lidar, existing mapping algorithms usually rely on either images or lidar data; moreover both image-based and lidar-based systems often represent the map as a point cloud, while a continuous textured mesh representation would be useful for visualization and navigation purposes. In the proposed framework, we join the accuracy of the 3D lidar data, and the dense information and appearance carried by the images, in estimating a visibility consistent map upon the lidar measurements, and refining it photometrically through the acquired images. We evaluate the proposed framework against the KITTI dataset and we show the performance improvement with respect to two state of the art urban mapping algorithms, and two widely used surface reconstruction algorithms in Computer Graphics.
Image Classification Using Quantum Inference on the D-Wave 2X (2018)

We use a quantum annealing D-Wave 2X computer to obtain solutions to NP-hard sparse coding problems. To reduce the dimensionality of the sparse coding problem to fit on the quantum D-Wave 2X hardware, we passed downsampled MNIST images through a bottleneck autoencoder. To establish a benchmark for classification performance on this reduced dimensional data set, we built two deep convolutional neural networks (DCNNs). The first DCNN used an AlexNet-like architecture and the second a state-of-the-art residual network (RESNET)model, both implemented in TensorFlow. The two DCNNs yielded classification scores of 94.54 ± 0.7% and 98.8 ± 0.1%, respectively. As a control, we showed that both DCNN architectures produced near-state-of-the-art classification performance ( ~ 99%) on the original MNIST images. To obtain a set of optimized features for inferring sparse representations of the reduced dimensional MNIST dataset, we imprinted on a random set of 47 image patches followed by an off-line unsupervised learning algorithm using stochastic gradient descent to optimize for sparse coding. Our single-layer of sparse coding matched the stride and patch size of the first convolutional layer of the AlexNet-like DCNN and contained 47 fully-connected features, 47 being the maximum number of dictionary elements that could be embedded onto the D-Wave 2X hardware. When the sparse representations inferred by the D-Wave 2X were passed to a linear support vector machine, we obtained a classification score of 95.68%. We found that the classification performance supported by quantum inference was maximal at an optimal level of sparsity corresponding to a critical value of the sparsity/reconstruction error trade-off parameter that previous work has associated with a second order phase transition, an observation supported by a free energy analysis of D-Wave energy states. We mimicked a transfer learning protocol by feeding the D-Wave representations into a multilayer perceptron (MLP), yielding 98.48% classification performance. The classification performance supported by a single-layer of quantum inference was superior to that supported by a classical matching pursuit algorithm set to the same level of sparsity. Whereas the classification performance of both DCNNs declined as the number of training examples was reduced, the classification performance supported by quantum inference was insensitive to the number of training examples. We thus conclude that quantum inference supports classification of reduced dimensional MNIST images exceeding that of a size-matched AlexNet-like DCNN and nearly equivalent to a state-of-the-art RESNET DCNN.
Fibrin Glue Enhances Adipose-Derived Stromal Cell Cytokine Secretion and Survival Conferring Accelerated Diabetic Wound Healing (2018)

Although several vehicles have shown to successfully act as cell carrier systems in preclinical trials, regulatory issues have prohibited clinical usage for chronic wounds. By demonstrating the ability of fibrin glue to act as a carrier vehicle for ASCs, while simultaneously enhancing cellular regenerative function and viability, this study is a proponent of clinical translation for ASC-based therapies.
Model-based Adaptation of Cloud Computing Applications (2013)

In this paper we propose a provider-managed, model-based adaptation approach for cloud computing applications, allowing customers to easily specify application behavior goals or adaptation rules. Delegating control over corrective actions to the cloud provider will pose advantages for both, customers and providers. Customers are relieved of effort and expertise requirements necessary to build sophisticated adaptation solutions, while providers can incorporate and analyze data from a multitude of customers to improve adaptation decisions. The envisioned approach will enable increased application performance, as well as cost savings for customers, whereas providers can manage their infrastructure more efficiently.
Comparative analysis of the DNA staining efficiencies of different fluorescent dyes in preparative agarose gel electrophoresis (2005)

Ethidium bromide (EB) is a mutagen and toxin that is widely used in the laboratory for visualization of nucleic acids. Safer nucleic acid stains, such as SYBR Gold, SYBR Green, GoldView, GeneFinder, and GoldStar, have been developed. However, there has been no systematic comparative analysis of the staining efficiencies of these dyes. In the present study, SYBR Gold, SYBR Green I, GoldView and EB were compared. Although both SYBR Gold and SYBR Green alter electrophoretic mobility and thus DNA size estimates, they are cost-effective alternatives to EB. SYBR Gold was more sensitive than SYBR Green I at detecting short fragments, but 50-bp bands were clearly visible using either dye when visualized with a long integration time. SYBR Gold or SYBR Green I are sensitive and relatively safe alternatives to EB. In our laboratory, the SYBR Gold method is now used routinely by all members of our group with great consistency and success.
Etching Silicon Nitride and Silicon Oxide Using Ethylene Glycol / Hydrofluoric Acid Mixtures (1980)

Concentrated (49%) aqueous HF and ethylene glycol solutions were investigated for a wet strip process requiring a LPCVD Si 3 N4 to thermal SiO2 etch rate selectivity of between 1 and 2. Si 3 N4 etch rates of higher than 20 nm per minute were also desired in order to obtain high throughputs on the single-wafer spray tool. Water, temperature, and HF concentration were found to play a significant role in defining both the etch rates and etch-rate selectivity of LPCVD Si 3 N4 and thermal SiO2 films. The desired Si 3 N4:SiO2 selectivity was achieved at low HF concentrations; at higher HF concentrations, the selectivity decreased rapidly below 1. Water additions to the system produced similar results. Particulate contamination levels were also significantly reduced when a deionized water rinse was used.
Behavioral Modeling of RF Power Amplifiers Using Adaptive Recursive Polynomial Functions (2006)

In this paper a novel adaptive approach is used to model the behavior of a nonlinear RF power amplifier with memory. The recursive input to the model enables a reduction of the number of coefficients required to model the system. Furthermore the equation-error approach used does not suffer from the convergence problems experienced using other recursive adaptive techniques. Validation of the approach was achieved using separate training and validation signals from various nonlinear power amplifiers. The improved performance of the proposed approach was measured using goodness of fit statistics and compared against existing methods
Standardizing research methods for prognostics (2008)

Prognostics and health management (PHM) is a maturing system engineering discipline. As with most maturing disciplines, PHM does not yet have a universally accepted research methodology. As a result, most component life estimation efforts are based on ad-hoc experimental methods that lack statistical rigor. In this paper, we provide a critical review of current research methods in PHM and contrast these methods with standard research approaches in a more established discipline (medicine). We summarize the developmental steps required for PHM to reach full maturity and to generate actionable results with true business impact.
T cell competition for the antigen-presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens (1999)

We recently demonstrated that spleen cells primed against dominant BALB.B antigens can inhibit the cytotoxic T lymphocyte (CTL) response against subdominant antigens in vitro. In this study, we show that this interference is dependent on CD8+, but not CD4+, T cells directed against dominant antigens. Similar to immunodominance in vivo, T cell interference in vitro required presentation of dominant and subdominant antigens by the same antigen-presenting cell. In vivo priming with cells expressing dominant and subdominant antigens did not induce long-lasting unresponsiveness against the latter. These results support a model in which immunodominance is mediated by T cell competition. In line with this, we found that the immunodominance effects in the CTL response against these minor histocompatibility antigens could be broken by immunization with live bone marrow-derived dendritic cells.
Rapid and Quantitative Measurement of Hematite and Goethite in the Chinese Loess-Paleosol Sequence by Diffuse Reflectance Spectroscopy (2002)

Abstract The long, continuous deposition of dust in the Chinese loess plateau offers a unique opportunity to study the nature of Fe oxide formation in a wide range of climatic conditions. A technique to obtain quantitative estimates of the concentration of hematite and goethite in loess and paleosol samples is reported. Experiments using diffuse reflectance spectroscopy on sets of laboratory mixed and natural loess and paleosol samples show that it is possible to obtain rapid and quantitative estimates of the absolute concentration of hematite and goethite in the Chinese loess sediments. Typical loess and paleosol samples were deferrated using the CBD procedure to produce a natural matrix material to which hematite and goethite in known weight percentages were added to produce a set of calibration standards. Spectral violet, blue, green, yellow, orange, red and brightness of standards were calculated from the reflectance data and served as independent variables for a multiple linear regression analysis. The effect of changing matrix from loess to paleosol was overcome by including a variety of different loess and paleosol samples in the regression equations. The resulting calibration equations provide estimates of wt.% hematite and goethite and have correlation coefficients >0.93. The total measured hematite and goethite concentrations exhibited consistent variations with CBD extractable iron. Tests of the equations for buffering changes in matrix composition were run with samples of varying mineralogical composition (calcite, illite, etc. ) and demonstrated that the equations are well buffered for changes in matrix composition from loess to paleosol.
From revolution to evolution (1988)

Examples of revolutionary and evolutionary progress in the recent history of polymer science and engineering.
Textbook of cancer epidemiology (2003)

Abstract DOI 10.1002/cncr.11252
New glutarimide antibiotics, S-632-B1 and B2. II. Isolation, physico-chemical properties and chemical structure. (1989)

Antifungal antibiotics S-632-A1,A2,B1 and B2 were extracted with ethyl acetate from the filtered broth of Streptomyces hygroscopicus S-632 and isolated through a combination of conventional and reversed-phase silica gel column chromatography. On the basis of the spectral data, S-632-B1 and B2 were found to be new members of the glutarimide family of antibiotics. The chemical structures of these components were elucidated as two stereo-isomers of 3-(5,7-dimethyl-8,9-epoxy-2-hydroxy-4-oxo-6-decenyl)glutarimide.
Tripod operators for recognizing objects in range images: rapid rejection of library objects (2003)

The tripod operator, a class of feature extraction operators for range images which facilitate the recognition and localization of objects is described. It consists of three points in 3-space fixed at the vertices of an equilateral triangle and a procedure for making several scalar measurements in the coordinate frame of the triangle. The triangle is moved as a rigid body until the three vertices lie on the surface of some range image or modeled object. The resulting measurements are local shape features which are invariant under rigid motions. These features contain all the shape information in the surface points involved, and no other information. Tripod operators are applicable to all 3-D shapes. A cloud of points in feature space was generated for each object by random placement of the operator. Then new feature measurements were made by operator placements in a range image containing one of those objects. Using a simple nearest-neighbor approach, the authors determined which objects were rejected and which remained as recognition candidates. Experiments showed that tripod operators had excellent discriminating power.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reduced serum levels of a soluble form of the human adhesion receptor CD58 (LFA-3) in patients with inflammatory bowel disease. (1996)

The activation of monocytes, neutrophils, and B cells by T-lymphocytes appears to play a pivotal role in the pathophysiology of inflammatory bowel disease. The pan T cell marker CD2 and its ligand CD58 mediate these immune function. We asked whether serum levels of a soluble form of CD58 is altered in patients with inflammatory bowel disease. Soluble CD58 was measured in sera from 41 patients with Crohn's disease, 19 patients with ulcerative colitis, and 24 normal controls. Soluble CD58 levels were significantly decreased in sera from patients with ulcerative colitis and even more with Crohn's disease when compared to controls (p = 0.025 and p < 0.0001, respectively). Reduction of soluble CD58 serum levels correlated significantly with various humoral (e.g. erythrocyte sedimentation rate: r = -0.48, p = 0.0002) and clinical parameters of disease activity (e.g. CDAI: r = -0.44, p = 0.005). In conclusion, serum levels of soluble CD58 are reduced in patients with inflammatory bowel disease. Since soluble CD58 can block the CD2/CD58 interaction further studies have to show whether the reduction of soluble CD58 in patients with inflammatory bowel disease contributes to T cell adhesiveness in the mucosa.
Thermochemical transformation of sulfur compounds in Japanese domestic <i>Allium, Allium victorialis</i> L (2000)

Sulfur compounds contributed to the health promotion in Allium species are produced via enzymic and thermal reactions. Potent antithrombotic agents which have been identified as allyl trisulfides, dithiins, and ajoene in garlic (A. sativum) and caucas (A. victorialis) are thermochemically transformed from allicin (allyl 2-propenethiosulfinate). The leaves and stems of Japanese domestic Allium plant, A. victorialis L. which is widely distributed in the northern part of Japan, under the name "Gyoja-ninniku" is a nutritious vegetable. The significant flavor compounds of caucas are methyl allyl disulfide (Chinese chive odor), diallyl disulfide (garlic-like odor), and dimethyl disulfide and methyl allyl trisulfide (pickles-like odor) among more than 85 peaks on the gas chromatogram. 2-Vinyl-4H-1,3-dithiin and 3,4-dihydro-3-vinyl-1,2-dithiin as platelet aggregation inhibitors were found eliminated in dichloromethane extract of caucas. The significant health promoting factors, allyl trisulfides and dithiins were relatively increased when caucas was cooked on a frying pan.
Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria (2014)

Polymyxins are polycationic antimicrobial peptides that are currently the last-resort antibiotics for the treatment of multidrug-resistant, Gram-negative bacterial infections. The reintroduction of polymyxins for antimicrobial therapy has been followed by an increase in reports of resistance among Gram-negative bacteria. Some bacteria, such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, develop resistance to polymyxins in a process referred to as acquired resistance, whereas other bacteria, such as Proteus spp., Serratia spp., and Burkholderia spp., are naturally resistant to these drugs. Reports of polymyxin resistance in clinical isolates have recently increased, including acquired and intrinsically resistant pathogens. This increase is considered a serious issue, prompting concern due to the low number of currently available effective antibiotics. This review summarizes current knowledge concerning the different strategies bacteria employ to resist the activities of polymyxins. Gram-negative bacteria employ several strategies to protect themselves from polymyxin antibiotics (polymyxin B and colistin), including a variety of lipopolysaccharide (LPS) modifications, such as modifications of lipid A with phosphoethanolamine and 4-amino-4-deoxy-L-arabinose, in addition to the use of efflux pumps, the formation of capsules and overexpression of the outer membrane protein OprH, which are all effectively regulated at the molecular level. The increased understanding of these mechanisms is extremely vital and timely to facilitate studies of antimicrobial peptides and find new potential drugs targeting clinically relevant Gram-negative bacteria.
선문자B 서판의 사람들 (2009)

This paper examined the Mycenaean Linear B tablets and the `people` revealed on them, focusing on the following three points. 1. The palace centers which used the Linear B tablets show remarkable similarity and uniformity in their economic and social system, material life and the `people,` though the palace sites were widely dispersed in time and space. So we can assume that the political entities flourished in Mainland and Crete had nearly the same palatial system. 2. The peoples on the tablets can be divided into three categories. The first one includes a variety of central and local officials performing their works for the palace centers. Wanax was a dominating figure on top of the bureaucratic structure. However, he was not an autocratic ruler such as Egyption pharaoh and Hittite king but chief of the polity and supreme commander of the power elites. Essentially there were no differences in their ownership of the land, in religious role, or in the control of the artisans and army between wanax and other high officials. The second category of the people was the local inhabitants who were obliged to pay tax and enlisted for the military duty. They had to provide the labour such as raising sheep or farming for the center. They were organized in corporate body called damos, an entity, taking part in religious activities and awarding its land to some high officials. Damos was not a passive object controlled one-sidedly by the center, but performed various functions as an autonomous local body. The working group directly controlled by the palace center was the third category of the people. It includes various groups of the dependent workers, which was ranged from the bronze-smiths and very specialized workers making prestige goods and artifacts to the slaves completely relied on the palace for their food. 3. The third dependant working group played a significant role for the palace economy and as a main source of the Mycenaean state power. The solidarity of the elites and the close relationships among the palaces were another factors strengthening their power.