gebhart/patrepeval huggingface dataset:
The Structural Behavior of Glass Pressure Hulls (1972)

The structural response of spherical and hemispherical glass shells for use on glass pressure vessels was studied under external hydro-static and cyclic pressure. A COMPUTERIZED ANALYSIS TRADING OF THE VARIABLES IN THE JOINT PROBLEM IS PRESENTED. Final joint geometries are discussed and data on chemically strengthened glass hemispherical shells with equatorial joint rings under fatigue conditions are presented. Relatively efficient small pressure vessels of chemically strengthened glass appear practical for unmanned noncritical applica-tions to 20,000 ft.
Charge State Coalescence During Electrospray Ionization Improves Peptide Identification by Tandem Mass Spectrometry (2012)

We report the effects of supercharging reagents dimethyl sulphoxide (DMSO) and m-nitrobenzyl alcohol (m-NBA) applied to untargeted peptide identification, with special emphasis on non-tryptic peptides. Peptides generated from a mixture of five standard proteins digested with trypsin, elastase, or pepsin were separated with nanoflow liquid chromatography using mobile phases modified with either 5% DMSO or 0.1%m-NBA. Eluting peptides were ionized by online electrospray and sequenced by both CID and ETD using data-dependent MS/MS. Statistically significant improvements in peptide identifications were observed with DMSO co-solvent. In order to understand this observation, we assessed the effects of supercharging reagents on the chromatographic separation and the electrospray quality. The increase in identifications was not due to supercharging, which was greater for the 0.1%m-NBA co-solvent and not observed for the 5.0% DMSO co-solvent. The improved MS/MS efficiency using the DMSO modified mobile phase appeared to result from charge state coalescence.
Internet-wide study of DNS cache injections (2017)

DNS caches are an extremely important tool, providing services for DNS as well as for a multitude of applications, systems and security mechanisms, such as anti-spam defences, routing security (e.g., RPKI), firewalls. Subverting the security of DNS is detrimental to the stability and security of the clients and services, and can facilitate attacks, circumventing even cryptographic mechanisms. We study the caching component of DNS resolution platforms in diverse networks in the Internet, and evaluate injection vulnerabilities allowing cache poisoning attacks. Our evaluation includes networks of leading Internet Service Providers and enterprises, and professionally managed open DNS resolvers. We test injection vulnerabilities against known payloads as well as a new class of indirect attacks that we define in this work. Our Internet evaluation indicates that more than 92% of the Internet's DNS resolution platforms are vulnerable to records injection and can be persistently poisoned.
NF-κB/Rel Proteins Are Required for Neuronal Differentiation of SH-SY5Y Neuroblastoma Cells (1999)

The expression, cellular localization, and activation of the NF-kappaB/Rel transcription factors are altered during neuronal differentiation, but the significance is unclear. Here we investigate the requirement for NF-kappaB/Rel proteins in neuronal differentiation. SH-SY5Y neuroblastoma cells were induced to differentiate with retinoic acid (RA) or 12-O-tetradecanoylphorbol 13-acetate (TPA), and differentiation was demonstrated by morphological criteria and the enhanced expression of Bcl-2. NF-kappaB was transiently activated after the addition of the differentiation inducers before the morphological signs of differentiation and the enhanced Bcl-2 synthesis. The onset of NF-kappaB activation coincided with a significant reduction in the amount of only one of four NF-kappaB-inhibitory proteins examined (I-kappaBbeta). In contrast, NF-kappaB activation and the reduction in I-kappaBbeta failed to occur in SH-SY5Y cells transformed with I-kappaBalphaM, a dominant-negative inhibitor of NF-kappaB/Rel proteins. These I-kappaBalphaM-expressing cells failed to differentiate into neuronal cell types when treated with RA or TPA, and the increased Bcl-2 synthesis was blocked. Therefore, NF-kappaB/Rel proteins are required for neuronal differentiation of SH-SY5Y neuroblastoma cells.
Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer (1994)

<h3>Objective:</h3> To test the hypothesis that the regular use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is negatively associated with the risk of subsequent colorectal cancer. <h3>Design:</h3> Case-control study with four age- and sex-matched control subjects for each incident colorectal cancer case. Population and Setting: Patient population of a large municipal teaching hospital in Atlanta, Ga. <h3>Main Outcome Measure:</h3> Odds of colorectal cancer as a function of aspirin, nonaspirin NSAIDs, and acetaminophen dispensed to the study population in the 4 years prior to incident colorectal cancer diagnosis. <h3>Main Results:</h3> The risk of colorectal cancer estimated by odds ratios decreased with inceasing days of exposure to aspirin linearly in a dose-dependent fashion (likelihood ratio statistic: for cumulative days,<i>P</i><.001; for cumulative dose,<i>P</i><.0001). The coefficient for days of exposure to aspirin was highly significant even when modeled as a continuous variable (<i>P</i>=.001). There appeared to be a threshold above which nonaspirin NSAIDs afforded protection (likelihood ratio statistic: for cumulative days,<i>P</i>=.021; for cumulative dose,<i>P</i>=.019). Acetaminophen conferred no risk reduction. <h3>Conclusion:</h3> The results of previous experimental animal models, interventional case studies, and some but not all epidemiological investigations and the present data point toward a causal relationship between NSAID use and the prevention of cancer of the large bowel and rectum. Because of the potential gastrointestinal and renal side effects of NSAID use, particularly in the elderly, chemoprevention trials are now needed to allow riskbenefit analysis in populations at high risk for colorectal cancer. (Arch Intern Med. 1994;154:394-399)
Model Level Coupling of Heterogeneous Embedded Systems (2004)

The integration platform GeneralStore is a tool that assists an integrated development process starting with a model and ending with executable code. The software features coupling of subsystems from different modeling domains on model level. From the coupled model it generates a running prototype by code generation. In addition to object-oriented system modeling for software components in embedded systems, it supports time-discrete and timecontinuous modeling concepts. The Unified Modeling Language (UML) metamodel is used for storing CASE data in a Meta Object Facility (MOF) object repository whereas XML Metadata Interchange format (XMI) is used to interchange this data with UML-CASE-tools. The CASE-tool chain we present in this paper further supports concurrent engineering including versioning and configuration management. It provides adaptors for the tools MATLAB/Simulink/Stateflow and various UML CASE tools such as MagicDraw, as well as an importer and exporter of UML/XMI. Utilizing the UML notation for an overall system design cycle, the focus of this paper lies on the coupling of heterogeneous subsystems and on a new code generation and coupling approach.
Genetic evidence for an activator required for induction of colicin-like bacteriocin 28b production in Serratia marcescens by DNA-damaging agents (1996)

Bacteriocin 28b production is induced by mitomycin in wild-type Serratia marcescens 2170 but not in Escherichia coli harboring the bacteriocin 28b structural gene (bss). Studies with a bss-lacZ transcriptional fusion showed that mitomycin increased the level of bss gene transcription in S. marcescens but not in the E. coli background. A S. marcescens Tn5 insertion mutant was obtained (S. marcescens 2170 reg::Tn5) whose bacteriocin 28b production and bss gene transcription were not increased by mitomycin treatment. Cloning and DNA sequencing of the mutated region showed that the Tn5 insertion was flanked by an SOS box sequence and three genes that are probably cotranscribed (regA, regB, and regC). These three genes had homology to phage holins, phage lysozymes, and the Ogr transcriptional activator of P2 and related bacteriophages, respectively. Recombinant plasmid containing this wild-type DNA region complemented the reg::Tn5 regulatory mutant. A transcriptional fusion between a 157-bp DNA fragment, containing the apparent SOS box upstream of the regA gene, and the cat gene showed increased chloramphenicol acetyltransferase activity upon mitomycin treatment. Upstream of the bss gene, a sequence similar to the consensus sequence proposed to bind Ogr protein was found, but no sequence similar to an SOS box was detected. Our results suggest that transcriptional induction of bacteriocin 28b upon mitomycin treatment is mediated by the regC gene whose own transcription would be LexA dependent.
A transmission imaging spectrograph and microfabricated channel system for DNA analysis (2000)

In this paper we present the development of a DNA analysis system using a microfabricated channel device and a novel transmission imaging spectrograph which can be efficiently incorporated into a high throughput genomics facility for both sizing and sequencing of DNA fragments. The device contains 48 channels etched on a glass substrate. The channels are sealed with a flat glass plate which also provides a series of apertures for sample loading and contact with buffer reservoirs. Samples can be easily loaded in volumes up to 640 nL without band broadening because of an efficient electrokinetic stacking at the electrophoresis channel entrance. The system uses a dual laser excitation source and a highly sensitive charge-coupled device (CCD) detector allowing for simultaneous detection of many fluorescent dyes. The sieving matrices for the separation of single-stranded DNA fragments are polymerized in situ in denaturing buffer systems. Examples of separation of single-stranded DNA fragments up to 500 bases in length are shown, including accurate sizing of GeneCalling fragments, and sequencing samples prepared with a reduced amount of dye terminators. An increase in sample throughput has been achieved by color multiplexing.
Intelligent money laundering monitoring and detecting system (2008)

Criminal elements in today's technology-driven society are using every means available at their disposal to launder the proceeds from their illegal activities. While dedicated efforts are contributed in combating with money laundering (ML) from multi-aspects, without a comprehensive and solid theoretical support, each of them is combating in its own way. To effectively and efficiently prevent and detect such diverse and complex activity, an Anti-Money Laundering (AML) solution should establish comprehensive, solid and fundamental knowledge framework of the monitoring and detecting process. Based on Simons' decision making theory this study proposed an intelligent-agent- oriented solution for money laundering monitoring and detecting process (MLMDP). In order for a more adaptive, intelligent and flexible solution for anti-money laundering, the intelligent agent technology is applied in this research to deal with the complex, dynamic, and distributed MLMDP. Intelligent agents with their properties of autonomy, reactivity and proactivity are well suited for money laundering prevention controls. Several types of agents are proposed and a novel and open multiagent architecture is presented for money laundering monitoring and detecting processes.
Elucidating body malodour to develop a novel body odour quencher. (1989)

The majority of antiperspirants and deodorants in the market are formulated by ingredients that act in such a way that the production of body odour is prevented as much as possible.A new type of deodorant that acts directly on chemical compounds responsible for offensive body odours once formed, was investigated. First of all, by analysing foot odour with GC/MS, short chain fatty acids, especially iso-valeric acid, were found to be responsible for the malodour. Short chain fatty acids were also identified within the armpit, another region possessing offensive body odour.Various experiments confirmed us that the conversion of volatile short chain fatty acids into involatile short chain fatty acid salts was the mechanism of choice for quenching acid malodour. A number of compounds were sought, out of which zinc oxide possessing fine particles was the most promising in terms of its outstanding ability to efficiently quench iso-valeric acid.By uniformly covering the surface of a spherical resin such as nylon, with zinc oxide, a hybrid powder that overcomes many of the shortcomings that zinc oxide alone may provoke, was obtained without sacrificing any of zinc oxide's deodorizing power. Body odour quenchers formulated with this hybrid powder were far more efficacious compared to the conventional deodorizers.
Tris(trimethylsilyl)silanetellurol: preparation, characterization, and synthetic utility of a remarkably stable tellurol (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTris(trimethylsilyl)silanetellurol: preparation, characterization, and synthetic utility of a remarkably stable tellurolBashir O. Dabbousi, Philip J. Bonasia, and John ArnoldCite this: J. Am. Chem. Soc. 1991, 113, 8, 3186–3188Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/ja00008a065https://doi.org/10.1021/ja00008a065research-articleACS PublicationsRequest reuse permissionsArticle Views226Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Molecular Characterization of Rectal Mucosa-Associated Bacterial Flora in Inflammatory Bowel Disease (2005)

The reduction in mucosa-associated bifidobacteria and increase in E. coli and clostridia in patients with IBD supports the hypothesis that an imbalance between potentially beneficial and pathogenic bacteria may contribute to its pathogenesis.
Validity of reported age and centenarian prevalence in New England (1999)

age validation can be performed for most centenarians in the North Eastern USA. Self or family reports of those between the ages of 100 and 107 years were dependable.
The Genetic Map of <i>Artemisia annua</i> L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin (2010)

Artemisinin is a plant natural product produced by Artemisia annua and the active ingredient in the most effective treatment for malaria. Efforts to eradicate malaria are increasing demand for an affordable, high-quality, robust supply of artemisinin. We performed deep sequencing on the transcriptome of A. annua to identify genes and markers for fast-track breeding. Extensive genetic variation enabled us to build a detailed genetic map with nine linkage groups. Replicated field trials resulted in a quantitative trait loci (QTL) map that accounts for a significant amount of the variation in key traits controlling artemisinin yield. Enrichment for positive QTLs in parents of new high-yielding hybrids confirms that the knowledge and tools to convert A. annua into a robust crop are now available.
Challenges and Opportunities in Consolidation at High Resource Utilization: Non-monotonic Response Time Variations in n-Tier Applications (2012)

A central goal of cloud computing is high resource utilization through hardware sharing; however, utilization often remains modest in practice due to the challenges in predicting consolidated application performance accurately. We present a thorough experimental study of consolidated n-tier application performance at high utilization to address this issue through reproducible measurements. Our experimental method illustrates opportunities for increasing operational efficiency by making consolidated application performance more predictable in high utilization scenarios. The main focus of this paper are non-trivial dependencies between SLA-critical response time degradation effects and software configurations (i.e., readily available tuning knobs). Methodologically, we directly measure and analyze the resource utilizations, request rates, and performance of two consolidated n-tier application benchmark systems (RUBBoS) in an enterprise-level computer virtualization environment. We find that monotonically increasing the workload of an n-tier application system may unexpectedly spike the overall response time of another co-located system by 300 percent despite stable throughput. Based on these findings, we derive a software configuration best-practice to mitigate such non-monotonic response time variations by enabling higher request-processing concurrency (e.g., more threads) in all tiers. More generally, this experimental study increases our quantitative understanding of the challenges and opportunities in the widely used (but seldom supported, quantified, or even mentioned) hypothesis that applications consolidate with linear performance in cloud environments.
Contextual revision in information seeking conversation systems (2004)

Contextual revision allows users to make incremental revisions to their previous query rather than providing a complete query each time. This is a powerful capability of conversation systems that can greatly reduce the word length of users' input, thereby improving speech recognition accuracy and simplifying NLU. We describe a novel method combining linguistic cues, semantic constraints, and data characteristics to address the ambiguities introduced by this construct.
Inhibition of Podocyte FAK Protects against Proteinuria and Foot Process Effacement (2010)

Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that plays a critical role in cell motility. Movement and retraction of podocyte foot processes, which accompany podocyte injury, suggest focal adhesion disassembly. To understand better the mechanisms by which podocyte foot process effacement leads to proteinuria and kidney failure, we studied the function of FAK in podocytes. In murine models, glomerular injury led to activation of podocyte FAK, followed by proteinuria and foot process effacement. Both podocyte-specific deletion of FAK and pharmacologic inactivation of FAK abrogated the proteinuria and foot process effacement induced by glomerular injury. In vitro, podocytes isolated from conditional FAK knockout mice demonstrated reduced spreading and migration; pharmacologic inactivation of FAK had similar effects on wild-type podocytes. In conclusion, FAK activation regulates podocyte foot process effacement, suggesting that pharmacologic inhibition of this signaling cascade may have therapeutic potential in the setting of glomerular injury.
Cloning, sequencing, and characterization of a membrane-associated Prevotella ruminicola B(1)4 beta-glucosidase with cellodextrinase and cyanoglycosidase activities (1995)

Prevotella ruminicola B(1)4 is a gram-negative, anaerobic gastrointestinal bacterium. A 2.4-kbp chromosomal fragment from P. ruminicola encoding an 87-kDa aryl-glucosidase (CdxA) with cellodextrinase activity was cloned into Escherichia coli DH5 alpha and sequenced. CdxA activity was found predominantly in the membrane fraction of both P. ruminicola and E. coli, but P. ruminicola localized the protein extracellularly while E. coli did not. The hydrolase had the highest activity on cellodextrins (3.43 to 4.13 mumol of glucose released min-1 mg of protein-1) and p-nitrophenyl-beta-D-glucoside (3.54 mumol min-1 mg of protein-1). Significant activity (70% of p-nitrophenyl-beta-D-glucoside activity) was also detected on arbutin and prunasin. Less activity was obtained with cellobiose, amygdalin, or gentiobiose. CdxA attacks cellodextrins from the nonreducing end, releasing glucose units, and appears to be an exo-1,4-beta-glucosidase (EC 3.2.1.74) which also is able to attack beta-1,6 linkages. Comparison of the deduced amino acid sequence with other glycosyl-hydrolases suggests that this enzyme belongs to family 3 (B. Henrissat, Biochem. J. 280:309-316, 1991). On the basis of this sequence alignment, the catalytic residues are believed to be Asp-275 and Glu-265. This is the first report of a cloned ruminal bacterial enzyme which can cleave cyanogenic plant compounds and which may therefore contribute to cyanide toxicity in ruminants.
Preparation of Aminobenzoic Acid Esters of Substituted Monoalkylamino Alcohols (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of Aminobenzoic Acid Esters of Substituted Monoalkylamino AlcoholsSamuel D. Goldberg, William F. Ringk, and Paul E. SpoerriCite this: J. Am. Chem. Soc. 1939, 61, 12, 3562–3564Publication Date (Print):December 1, 1939Publication History Published online1 May 2002Published inissue 1 December 1939https://pubs.acs.org/doi/10.1021/ja01267a100https://doi.org/10.1021/ja01267a100research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Before and beyond ABA: upstream sensing and internal signals that determine ABA accumulation and response under abiotic stress (2005)

Sensing and signalling events that detect abiotic stress-induced changes in plant water status and initiate downstream stress responses such as ABA (abscisic acid) accumulation and osmoregulation remain uncharacterized in plants. Although conclusive results are lacking, recent results from plants, and analogies to signalling in other organisms, suggest possible mechanisms for sensing altered water status and initial transduction of that signal. Internal signals that act downstream of ABA and modulate stress responses to reflect the type and severity of the stress and the metabolic status of the plant are also not well understood. Two specific types of signalling, sugar sensing and reactive oxygen signalling, are likely to be modulators of ABA response under stress. For both upstream sensing and signalling of plant water status as well as downstream modulation of ABA response, present results suggest several genetic strategies with high potential to increase our understanding of the molecular basis by which plants sense and respond to altered water status.