gebhart/patrepeval huggingface dataset:
Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-γ (2001)

To understand the effects of cytokines on epithelial cells in asthma, we have investigated the effects of interleukin (IL)-4, IL-13, and interferon (IFN)-gamma on barrier function and wound healing in Calu-3 human lung epithelial cells. IL-4 and IL-13 treatment of Calu-3 cells grown on Transwell filters resulted in a 70-75% decrease in barrier function as assessed by electrophysiological and [(14)C]mannitol flux measurements. In contrast, IFN-gamma enhanced barrier function threefold using these same parameters. Cells treated concurrently with IFN-gamma and IL-4 or IL-13 showed an initial decline in barrier function that was reversed within 2 days, resulting in barrier levels comparable to control cells. Analysis of the tight junction-associated proteins ZO-1 and occludin showed that IL-4 and IL-13 significantly reduced ZO-1 expression and modestly decreased occludin expression compared with controls. IFN-gamma, quite unexpectedly given its enhancing effect on barrier function, reduced expression of ZO-1 and occludin to almost undetectable levels compared with controls. In wound-healing assays of cells grown on collagen I, IL-4 and IL-13 decreased migration, whereas IFN-gamma treatment enhanced migration, compared with control cells. Addition of IFN-gamma, in combination with IL-4 or IL-13, restored migration of cells to control levels. Migration differences observed between the various cytokine treatments was correlated with expression of the collagen I-binding alpha(2)beta(1)-integrin at the leading edge of cells at the wound front; alpha(2)beta(1)-integrin expression was decreased in IFN-gamma-treated cells compared with controls, whereas it was highest in IL-4- and IL-13-treated cells. These results demonstrate that IL-4 and IL-13 diminish the capacity of Calu-3 cells to maintain barrier function and repair wounds, whereas IFN-gamma promotes epithelial restitution by enhancing barrier function and wound healing.
Android Malware Detection via a Latent Network Behavior Analysis (2012)

The rapid growth of smartphones has lead to a renaissance for mobile application services. Android and iOS now as the most popular smartphone platforms offer a public marketplace respectively, the Android Market and App Store- but operate with dramatically different approaches to prevent malware on their devices. In Android platform, developer not only can directly deliver their apps on the Android market without strict review process, but also is capable to put the non-official verified apps marketplace (i.e., Applanet, AppBrain and so on). In this study, we purpose an automatic Android malware detection mechanism based on the result from sandbox. We leverage network spatial feature extraction of Android apps and independent component analysis (ICA) to find the intrinsic domain name resolution behavior of Android malware. The proposed mechanism that identifies the Android malware can achieve in automatic way. For evaluation the proposed approach, the public Android malware apps dataset and popular benign apps collected from Android Market are used for evaluating the effectiveness in analyzing the grouping ability and the effectiveness of identifying the Android malware. The proposed approach successfully identifies malicious Android Apps close to 100% accuracy, precision and recall rate.
Data mining information visualisation - beyond charts and graphs (2003)

Data mining has become a major academic research area over the last ten years. However, in the transition from academic prototypes to commercial products there have been few successes with commercial data mining applications failing to make any significant impact in the marketplace. In this paper it is argued that most data mining applications concentrate on the model-building phase of the data mining process and rarely engage the user in other stages. The paper reviews the challenges of producing successful data mining applications and in particular the role of information visualisation. Visualisation in data mining tends to be used to present final results, rather than playing an important part throughout the entire process. We argue that an immersive environment may provide the user with a more suitable interface than is commonly offered. We present a virtual data mining environment which attempts to integrate a data mining application interface and information visualisation in a seamless manner, using the concept of 'liquid data'.
Tracking brachytherapy sources using emission imaging with one flat panel detector (2009)

This work proposes to use the radiation from brachytherapy sources to track their dwell positions in three-dimensional (3D) space. The prototype device uses a single flat panel detector and a BB tray. The BBs are arranged in a defined pattern. The shadow of the BBs on the flat panel is analyzed to derive the 3D coordinates of the illumination source, i.e., the dwell position of the brachytherapy source. A kilovoltage x-ray source located 3.3 m away was used to align the center BB with the center pixel on the flat panel detector. For a test plan of 11 dwell positions, with an Ir-192 high dose rate unit, one projection was taken for each dwell point, and locations of the BB shadows were manually identified on the projection images. The 3D coordinates for the 11 dwell positions were reconstructed based on two BBs. The distances between dwell points were compared with the expected values. The average difference was 0.07 cm with a standard deviation of 0.15 cm. With automated BB shadow recognition in the future, this technique possesses the potential of tracking the 3D trajectory and the dwell times of a brachytherapy source in real time, enabling real time source position verification.
Vitamin D3: a helpful immuno-modulator (2011)

The active metabolite of vitamin D, 1α, 25-dihydroxyvitamin D3 [1,25(OH)(2) D3], is involved in calcium and phosphate metabolism and exerts a large number of biological effects. Vitamin D3 inhibits parathyroid hormone secretion, adaptive immunity and cell proliferation, and at the same time promotes insulin secretion, innate immunity and stimulates cellular differentiation. The role of vitamin D3 in immunoregulation has led to the concept of a dual function as both as an important secosteroid hormone for the regulation of body calcium homeostasis and as an essential organic compound that has been shown to have a crucial effect on the immune responses. Altered levels of vitamin D3 have been associated, by recent observational studies, with a higher susceptibility of immune-mediated disorders and inflammatory diseases. This review reports the new developments with specific reference to the metabolic and signalling mechanisms associated with the complex immune-regulatory effects of vitamin D3 on immune cells.
Technology-driven resource sharing (1993)

La notion de partage des ressources pour les bibliotheques et les centres d'information est revue: l'evolution de la conception du partage des ressources et des activites bibliotheconomiques doit s'appuyer sur l'existence de reseaux de communication de donnees permettant d'objectiver une circulation de donnees documentaires moins contraintes, ce qui change en particulier l'approche du pret interbibliotheque
Oxidant stress stimulates Ca<sup>2+</sup>-activated chloride channels in the apical activated membrane of cultured nonciliated human nasal epithelial cells (2005)

Respiratory tissues can be damaged by the exposure of airway epithelial cells to reactive oxygen species that generate oxidative stress. We studied the effects of the hydroxyl radical *OH, for which there is no natural intra- or extracellular scavenger, on a Ca(2+)-activated chloride channel (CACC) that participates in Cl(-) secretion in the apical membrane of airway epithelial cells. We identified and characterized CACC in cell-attached and in inside-out excised membrane patches from the apical membrane of cultured nonciliated human nasal epithelial cells. In these cells, the CACC was outwardly rectified, Ca(2+)/calmodulin-kinase II, and voltage dependent. The channel was activated in cell-attached and inside-out patches in a bath solution containing millimolar [Ca(2+)] and ran down quickly. The channel was reversibly or irreversibly activated by exposure of the internal surface of the membrane to *OH, which depended on the concentration and the duration of exposure to H(2)O(2). CACC activity evoked by oxidative stress was inhibited by 1,3-dimethyl-2-thiurea, an antioxidant that scavenges hydroxyl radicals, and by the reduced form of glutathione. The oxidized SH residues could be close to the Ca(2+)/calmodulin kinase site. The reversible or irreversible activation of CACC after a period of oxidative stress without change in [Ca(2+)] is a new observation. CACC play a direct role in mucus production by goblet cells and may thus contribute to the pathogenesis of asthma.
Recent Advances in Ion Plating (1974)

Ion plating is a generic term applied to atomistic deposition processes in which the substrate is subjected to a flux of high-energy ions sufficient to cause appreciable sputtering before and during film deposition.1-3) In this paper recent work on areas relevant to ion plating will be discussed. These include contamination effects in sputter cleaning, ion bombardment effects on the composition of deposited glasses, and ion bombardment effects on the morphology and density of deposited metals. Several new source configurations will be briefly discussed.
Production of Recombinant Hydroxylated Human Type III Collagen Fragment in <i>Saccharomyces cerevisiae</i> (1998)

A recombinant hydroxylated fragment of human type III collagen has been produced in Saccharomyces cerevisiae by coordinated coexpression of a collagen gene fragment together with both the alpha- and beta-subunit genes for prolyl-4-hydroxylase (EC 1.14.11.2). The collagen fragment consisted of 255 residues of the helical domain and the complete C-telopeptide and C-propeptide domains. It was inserted under the control of the ethanol-inducible ADH2 promoter in a multicopy, TRP1-selectable, yeast expression vector, YEpFlag1. The prolyihydroxylase subunit genes were cloned on either side of a bidirectional galactose-inducible promoter in a low-copy minichromosome yeast expression vector, pYEUra3, which is URA3 selectable. Coordinated expression of the three different gene products after cotransformation into S. cerevisiae was detected by immunoblotting. Amino acid analysis of an immunoreactive collagen fraction demonstrated the presence of hydroxyproline, while the presence of a triple-helical domain in the collagen fragment was demonstrated by its resistance to pepsin proteolysis.
A Schur-complement method for sparse quadratic programming (1990)

Abstract In applying active-set methods to sparse quadratic programs, it is desirable to utilize existing sparse-matrix techniques. We describe a quadratic programming method based on the classical Schur complement. Its key feature is that much of the linear algebraic work associated with an entire sequence of iterations involves a fixed sparse factorization. Updates are performed at every iteration to the factorization of a smaller matrix, which may be treated as dense or sparse.
Intravenous Ferumoxytol Allows Noninvasive MR Imaging Monitoring of Macrophage Migration into Stem Cell Transplants (2012)

Iron oxide loading of macrophages in the reticuloendothelial system by means of intravenous ferumoxytol injection can be utilized to monitor differential migration of bone marrow macrophages into viable and apoptotic MASIs in a rat model.
Evaluation of Vehicle-in-the-Loop Tests for Wireless V2X Communication (2019)

The performance of wireless communication systems is fundamentally determined by the properties of the underlying wireless communication channel. Vehicular communication channels exhibit time-variant multi-path propagation with non-stationary channel statistics. Thus, channel emulation tools for the reproducible test of wireless communication systems are urgently needed to enable the development of ultra-reliable low-latency communication links. In this paper we validate the vehicle-in-the-loop (ViL) test of vehicle-to-everything (V2X) communication links by means of time-variant channel emulation. The validation is performed by comparing the received signal strength indicator (RSSI) and packet error rate (PER) of measurements on a proving ground with the RSSI and PER obtained from ViL tests. For the ViL tests, the wireless communication channel is emulated using a geometry-based stochastic channel model, which is updated in real-time, dependent on the position and velocity of the vehicles. We collect results of different scenarios on the proving ground and from ViL tests. The results show an qualitative match between ViL test and measurement on the proving ground. An exact quantitative match can be obtained with the calibration parameters from the measurements.
Alternate spin profile reconstruction in low-PMD fibers (2005)

Any kind of spin profile transferred into fibers during the drawing process is accurately determined by exploiting a cut-back method together with a deterministic waveplate model. Reconstructed constant and sinusoidal spin profiles are shown.
Selective detection of Mycoplasma fermentans by polymerase chain reaction and by using a nucleotide sequence within the insertion sequence-like element (1992)

A new assay using the polymerase chain reaction to amplify a 206-nucleotide specific gene sequence within the insertion sequence-like element of Mycoplasma fermentans has been developed. The unique insertion sequence-like element exists in multiple copies in the M. fermentans genome. The assay selectively amplifies DNA from all strains of M. fermentans tested. In contrast, DNA from other species of human and nonhuman mycoplasmas, common tissue culture-contaminating mycoplasmas, and bacteria, as well as human, monkey, and mouse tissues do not produce the amplified DNA products specific for M. fermentans.
Mimic: computing models for opaque code (2015)

Opaque code, which is executable but whose source is unavailable or hard to process, can be problematic in a number of scenarios, such as program analysis. Manual construction of models is often used to handle opaque code, but this process is tedious and error-prone. (In this paper, we use model to mean a representation of a piece of code suitable for program analysis.) We present a novel technique for automatic generation of models for opaque code, based on program synthesis. The technique intercepts memory accesses from the opaque code to client objects, and uses this information to construct partial execution traces. Then, it performs a heuristic search inspired by Markov Chain Monte Carlo techniques to discover an executable code model whose behavior matches the opaque code. Native execution, parallelization, and a carefully-designed fitness function are leveraged to increase the effectiveness of the search. We have implemented our technique in a tool Mimic for discovering models of opaque JavaScript functions, and used Mimic to synthesize correct models for a variety of array-manipulating routines.
Pontine Reticular Formation Neurons and Motor Activity (1978)

Article MetricsDownloadsCitationsNo data available.012345AugSepOctNovDecJan340Total6 Months12 MonthsTotal number of downloads for the most recent 6 whole calendar months.
Heating and cutting of biological tissue by highly absorbed laser beams: theoretical model and experiments (1990)

A model for calculating temperature fields and ablation processes in tissue was developed. The model assumes three different stages experienced by the tissue during a complete ablation process. The consecutive steps are: heating, boiling and ablation. The model has been examined by calculations and experimental measurements of temperature fields in various kinds of biological tissue, exposed to ablative or non-ablative laser beams in the range of low to moderate power densities. The model was able to determine temperature fields and thermal damage in tissue, as well as ablation parameters. This makes it a powerful tool for optimizing laser irradiation parameters for a variety of applications.
Reduced graphene oxide decorated with CuO–ZnO hetero-junctions: towards high selective gas-sensing property to acetone (2014)

The CuO–ZnO/rGO ternary composite is successfully prepared, in which valid p–n junctions exist between CuO and ZnO nanoparticles with the aid of rGO sheets. The presence of p–n junctions enables such a composite to possess outstanding sensing properties to acetone.
Magnebike: A magnetic wheeled robot with high mobility for inspecting complex‐shaped structures (2009)

Abstract This paper describes the Magnebike robot, a compact robot with two magnetic wheels in a motorbike arrangement, which is intended for inspecting the inner casing of ferromagnetic pipes with complex‐shaped structures. The locomotion concept is based on an adapted magnetic wheel unit integrating two lateral lever arms. These arms allow for slight lifting off the wheel in order to locally decrease the magnetic attraction force when passing concave edges, as well as laterally stabilizing the wheel unit. The robot has the main advantage of being compact (180 × 130 × 220 mm) and mechanically simple: it features only five active degrees of freedom (two driven wheels each equipped with an active lifter stabilizer and one steering unit). The paper presents in detail design and implementation issues that are specific to magnetic wheeled robots. Low‐level control functionalities are addressed because they are necessary to control the active system. The paper also focuses on characterizing and analyzing the implemented robot. The high mobility is shown through experimental results: the robot not only can climb vertical walls and follow circumferential paths inside pipe structures but it is also able to pass complex combinations of 90‐deg convex and concave ferromagnetic obstacles with almost any inclination regarding gravity. It requires only limited space to maneuver because turning on the spot around the rear wheel is possible. This high mobility enables the robot to access any location in the specified environment. Finally the paper analyzes the maximum payload for different types of environment complexities because this is a key feature for climbing robots and provides a security factor about the risk of falling and slipping. © 2009 Wiley Periodicals, Inc.
Distributed Bisection Method for Economic Power Dispatch in Smart Grid (2014)

In this paper, we present a fully distributed bisection algorithm for the economic dispatch problem (EDP) in a smart grid scenario, with the goal to minimize the aggregated cost of a network of generators, which cooperatively furnish a given amount of power within their individual capacity constraints. Our distributed algorithm adopts the method of bisection, and is based on a consensus-like iterative method, with no need for a central decision maker or a leader node. Under strong connectivity conditions and allowance for local communications, we show that the iterative solution converges to the globally optimal solution. Furthermore, two stopping criteria are presented for the practical implementation of the proposed algorithm, for which sign consensus is defined. Finally, numerical simulations based on the IEEE 14-bus and 118-bus systems are given to illustrate the performance of the algorithm.
Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential (2005)

Our results illustrate the importance of establishing calibrated RNA samples and reference datasets to objectively assess the performance of different microarray platforms and the proficiency of individual laboratories as well as the merits of various data analysis procedures. Thus, we are progressively coordinating the MAQC project, a community-wide effort for microarray quality control.
The<i>Arabidopsis</i>nectary is an ABC-independent floral structure (2001)

In contrast to the conservation of floral organ order in angiosperm flowers, nectary glands can be found in various floral and extrafloral positions. Since in Arabidopsis, the nectary develops only at the base of stamens, its specification was assayed with regard to the floral homeotic ABC selector genes. We show that the nectary can form independently of any floral organ identity gene but is restricted to the 'third whorl' domain in the flower. This domain is, in part, specified redundantly by LEAFY and UNUSUAL FLORAL ORGANS. Even though nectary glands arise from cells previously expressing the B class genes, their proper development requires the down-regulation of B class gene activity. While CRABS CLAW is essential for nectary gland formation, its ectopic expression is not sufficient to induce ectopic nectary formation. We show that in Arabidopsis multiple factors act to restrict the nectary to the flower, and surprisingly, some of these factors are LEAFY and UNUSUAL FLORAL ORGANS.
Economic Integration: The Single European Market and the NAFTA and Their Implications for Canada-UK Bilateral Trade and Investment (1998)

International business is increasingly being shaped by the trend towards economic integration which has engendered the establishment of large trading blocs characterised by internal free trade and common competition policies. To this extent, the world arena is now dominated by three major trading regions — the Americas (including Canada and South America), Europe (including eastern Europe) and Asia Pacific — the 'Global Triad' (Ohmae, 1985). However, while liberalisation is the essence of internal regional business transactions, it is arguable that greater protectionism and a more restricted legislative régime dominate in inter-triad trade and investment. This has profound implications for firms' international strategies where the affiliation of their domestic country to a particular economic grouping has ramifications for trade and investment in non-member countries.KeywordsEuropean UnionFree TradeEconomic IntegrationBilateral TradeFree Trade AgreementThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Yield Enhancement Techniques for 3D Memories by Redundancy Sharing among All Layers (2012)

Three-dimensional (3D) memories using through-silicon vias (TSVs) will likely be the first commercial applications of 3D integrated circuit technology. A 3D memory yield can be enhanced by vertical redundancy sharing strategies. The methods used to select memory dies to form 3D memories have a great effect on the 3D memory yield. Since previous die-selection methods share redundancies only between neighboring memory dies, the opportunity to achieve significant yield enhancement is limited. In this paper, a novel die-selection method is proposed for multi-layer 3D memories that shares redundancies among all of the memory dies by using additional TSVs. The proposed method uses three selection conditions to form a good multi-layer 3D memory. Furthermore, the proposed method considers memory fault characteristics, newly detected faults after bonding, and multiple memory blocks in each memory die. Simulation results show that the proposed method can significantly improve the multi-layer 3D memory yield in a variety of situations. The TSV overhead for the proposed method is almost the same as that for the previous methods.
Imetelstat therapy in refractory anemia with ring sideroblasts with or without thrombocytosis (2016)

Imetelstat therapy in refractory anemia with ring sideroblasts with or without thrombocytosis