gebhart/patrepeval huggingface dataset:
Effects of UV, 4NQO and TPA on gene expression in cultured human epidermal keratinocytes (1987)

In an approach to study effects of UV light on gene expression in human epidermal keratinocytes, a cDNA library was constructed from poly(A)RNA isolated after UV irradiation from cultured keratinocytes. The cDNA library was differentially screened with labelled cDNA probes synthesized on poly(A)RNA isolated from UV irradiated or nonirradiated keratinocytes. Forty clones were selected and subjected to further analysis, 31 of them are described in this report. Whereas total mRNA synthesis is reduced after UV irradiation or treatment with 4-NQO Northern blot analysis revealed that there is an at least relative increase in the level of mRNAs corresponding to the majority of the isolated cDNA clones. Among these 15 were identified as corresponding to mRNAs for 50K and 56K keratins and for 50K- and 46K-related keratin. In addition, clones were found corresponding to the proteinase inhibitor cystatin A and to the glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Treatment of keratinocytes with the tumor promoter TPA had no effect on the mRNA level for most of the clones except those corresponding to keratins. Our results indicate that in keratinocytes UV irradiation leads to a relative increase in the level of some mRNAs.
Type III .omega.-Agatoxins: A Family of Probes for Similar Binding Sites on L- and N-Type Calcium Channels (1994)

The peptide omega-agatoxin-IIIA (omega-Aga-IIIA) from venom of the funnel web spider Agelenopsis aperta is the only known agent that blocks L-type and N-type Ca channels with equal high potency (IC50 < or = 1 nM). From the same venom, we have purified and sequenced a family of peptides which are homologous to omega-Aga-IIIA but vary over 100-fold in their relative affinity for L-type versus N-type Ca channels. One of these, omega-Aga-IIIB, is 76 amino acids long and identical to omega-Aga-IIIA in 66 positions. We identified two other similar peptides, omega-Aga-IIIC and omega-Aga-IIID, as well as one single amino acid variant of omega-Aga-IIIA and two of omega-Aga-IIIB. The type III omega-agatoxins exhibit similar but distinct activities on voltage-gated Ca channels. omega-Aga-IIIA, omega-Aga-IIIB, and omega-Aga-IIID are nearly indistinguishable in their actions at the insect neuromuscular junction (no effect at 0.1 microM), on atrial T-type Ca channels (no effect at 0.5 microM), and in two assays for synaptosomal Ca channels: they are nearly equipotent inhibitors of 125I-omega-conotoxin GVIA binding to rat brain synaptic membranes (IC50 = 0.17-0.33 nM) and blockers of the K(+)-induced 45Ca2+ influx into chick brain synaptosomes (omega-Aga-IIIB, 1.2 nM; omega-Aga-IIIA, 2.4 nM). In contrast, omega-Aga-IIIA is a better blocker of locust Ca channels (IC50 approximately 10-50 nM) than is omega-Aga-IIIB. Finally, although omega-Aga-IIIA, omega-Aga-IIIB, and omega-Aga-IIID all block atrial L-type Ca channels, omega-Aga-IIIA is over 100-fold more potent. Thus, although type III omega-agatoxins appear to recognize a binding site common to L- and N-type Ca channels, omega-Aga-IIIB and omega-Aga-IIID identify differences between the two channels.
Adapting State-Intensive Non-Blocking Queries over Distributed Environments (2005)

Main memory is a critical resource in push-based non-blocking query processing, especially for queries with stateful operators. Works in the literature apply partitioned parallel processing to alleviate the stringent memory demands. However, main memory of a distributed system remains limited. Thus, there is a demand for efficient main memory usage even for partitioned parallel queries. In this work, we first investigate two adaptations, namely, disk-based adaptation and distributed adaptation, that adapt operator states when memory overflow happens for complex multi-input operators. We analyze the tradeoffs regarding the factors and polices to be used when adapting operator states to overcome memory overflow. Two approaches, namely, lazy-disk and active-disk adaptations, are proposed to integrate the disk-based and distributed adaptations when the aggregated main memory of a distributed system is not sufficient for the query processing. Both appproaches aim to maximize the overall throughput. Extensive experiments have been conducted on a working system. These experiments reveal various aspects of partitioned parallel processing and their adaptation strategies.
Learning Over Long Time Lags (2016)

The advantage of recurrent neural networks (RNNs) in learning dependencies between time-series data has distinguished RNNs from other deep learning models. Recently, many advances are proposed in this emerging field. However, there is a lack of comprehensive review on memory models in RNNs in the literature. This paper provides a fundamental review on RNNs and long short term memory (LSTM) model. Then, provides a surveys of recent advances in different memory enhancements and learning techniques for capturing long term dependencies in RNNs.
Pepsin-Digested Bovine Lactoferrin Induces Apoptotic Cell Death With JNK/SAPK Activation in Oral Cancer Cells (2005)

Lactoferrin, a member of the transferrin family, is iron-binding and a strongly cationic 76 kDa glycoprotein. In breast milk it is secreted in high concentrations from glandular epithelia and is also present in other exocrine fluids including saliva. In the present study, we examined the biological mechanisms of apoptosis induced by pepsin-digested-lactoferrin peptide (Lfn-p) in the human oral squamous cell carcinoma cell line SAS. We found that treatment with Lfn-p induced cell death with apoptotic nuclear changes, preceded by the cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in the apoptotic cells. Treatment with Lfn-p induced phosphorylation of extracellular signal-regulated kinase (ERK1/2), a member of the MAP kinase family, at early stages of apoptosis. Another MAP kinase, c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), was also phosphorylated by treatment with Lfn-p. Pretreatment of SAS cells with SP600125, a JNK/SAPK inhibitor, diminished Lfn-induced apoptosis, as assessed by determining released lactate dehydrogenase activity. On the other hand, the MEK1 inhibitors PD98059 or U0126 showed no effect on repression of cell death, but rather an increase. These results suggest that JNK/SAPK activation may play an important role in Lfn-p-induced apoptotic cell death of human oral squamous cell carcinoma cells.
Molecular random access memory cell (2001)

Electronically programmable memory devices utilizing molecular self-assembled monolayers are reported. The devices exhibit electronically programmable and erasable memory bits compatible with conventional threshold levels and a memory cell applicable to a random access memory is demonstrated. Bit retention times &gt;15 min have been observed.
Synthesis of a Novel Glycopeptide by Polymeranalogous Reaction of Gelatin with Mono‐6‐<i>para</i>‐toluenesulfonyl‐β‐cyclodextrin and its Supramolecular Properties (2010)

A synthetic model glycoprotein was successfully synthesized using gelatin and mono-6-para-toluenesulfonyl-β-cyclodextrin which were reacted under microwave conditions in basic media. The resulting glycoprotein is observed to form intermolecular inclusion complexes through complexation of the aromatic moieties along the polymer chain by the attached cyclodextrins. This phenomenon was analyzed and proven by 2D NMR spectroscopy (ROESY) and dynamic light scattering (DLS). Above the denaturation temperature, a strong increase of the hydrodynamic diameter was found due to enhanced supramolecular agglomeration. Such a novel glycoprotein with supramolecular self-recognition would be promising in biomedical applications serving as a drug-delivery basis polymer.
An ant-algorithm for the weighted minimum hitting set problem (2004)

We present an ant-based algorithm for finding good, near optimal solutions to the weighted minimum hitting set problem. We compare our results with the ones obtained by a greedy procedure and by an ad hoc genetic algorithm.
Resolving semantic heterogeneity in a federation of autonomous, heterogeneous database systems (2017)

Resolving Semantic Heterogeneity in a Federation of Autonomous, Heterogeneous Database Systems by Joachim HammerA Dissertation Presented to the F ACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (Computer Science) August 1994 Copyright 1994 Joachim Hammer
Product Composition from the Fast Pyrolysis of Polystyrene (1999)

Abstract Polystyrene has been pyrolysed in a fluidised bed pyrolysis reactor and the influence of pyrolysis temperature from 500 to 700°C on the yield and composition of the derived products has been determined. The main products from pyrolysis of polystyrene were a wax/oil product collected, as a condensed wax fraction and a separate oil fraction, using an industrial demister system. The oils and waxes were analysed by size exclusion chromatography to determine their molecular weight distribution, by Fourier transform infra-red spectrometry to determine their functional group composition and by gas chromatography to determine their detailed composition. The derived oils had a molecular weight distribution from 60 to 200 Da, with higher molecular weight material occurring in the wax fraction with a distribution of 60 to over 1000. Detailed analysis of the oils showed that the pyrolysis of polystyrene gave a mainly aromatic composition dominated by styrene and styrene oligomers. The oils also contained polycyclic aromatic hydrocarbons which increased in concentration as the pyrolysis temperature was increased to 700°C. Low concentrations of hydrogen, methane, ethane, ethene, propane, propene, butane and butene were also formed. There was an increase in gas yield with increasing temperature of pyrolysis. Keywords: Pyrolysisplasticspolystyrenerecycling
Subcutaneous Administration of Desmopressin as a Test of Maximal Urinary Concentrating Ability in the Fischer 344 Rat (1994)

AbstractDecreased maximal urinary concentrating ability after administration of vasopressin analogs is a sensitive indicator of some forms of nephrotoxicity. To evaluate the potential of subcutaneous injection of 1 -deamino-8-D-arginine vasopressin (desmopressin) as a provocative agent in testing maximal urinary concentrating ability, rats were administered desmopressin acetate subcutaneously and urine osmolality was measured. At all dosages used (3–300 ng/kg), urinary osmo-lality increased for the first 4 h after desmopressin administration. At dosages > 100 ng/kg, osmolality remained elevated for 8 h. The utility of desmopressin administration in detecting urinary concentrating defects was validated by pre-treating rats with sodium fluoride and measuring maximal urine concentrating ability after administration of 100 ng/kg desmopressin. Administration of 100 or 200 μmol sodium fluoride (NaF) intraperitoneally daily for 3 days, resulted in 55 and 60% decrease, respectively, in maximal urinary concentrating ability. In contrast, urinary excretion of N-acetyl-β-glucosaminidase (NAG) was not a sensitive measure of fluoride-induced nephrotoxicity. Key Words: Kidney concentrating ability—Kidney function testing—Toxicity—Renal—Fluoride—Pharmacology—1 - deamino - 8 - d - arginine vasopressin—Enzymes—Urinary—N-acetyl-β-glu-cosaminidase.
Mammographic Characteristics of 115 Missed Cancers Later Detected with Screening Mammography and the Potential Utility of Computer-aided Detection (2001)

Detection errors affected cases with calcifications and masses. CAD marked most (77%; 88 of 115) cancers missed at screening mammography that radiologists retrospectively judged to merit recall.
Wildcard dimensions, coding theory and fault-tolerant meshes and hypercubes (1995)

Hypercubes, meshes and tori are well known interconnection networks for parallel computers. The sets of edges in those graphs can be partitioned to dimensions. It is well known that the hypercube can be extended by adding a wildcard dimension resulting in a folded hypercube that has better fault-tolerant and communication capabilities. First we prove that the folded hypercube is optimal in the sense that only a single wildcard dimension ran be added to the hypercube. We then investigate the idea of adding wildcard dimensions to d-dimensional meshes and tori. Using techniques from error correcting codes we construct d-dimensional meshes and tori with wildcard dimensions. Finally, we show how these constructions can be used to tolerate edge and node faults in mesh and torus networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Impact of a Robotic Cat on Dementia Caregivers’ Psychosocial Work Environment – a Pilot Study (2015)

The Impact of a Robotic Cat on Dementia Caregivers’ Psychosocial Work Environment – a Pilot Study
Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation (2019)

Parkinson's Disease (PD) is a neurodegenerative disease for which there currently is no cure. Aggregation of the pre-synaptic protein α-synuclein (aSN) into oligomers (αSOs) is believed to play a key role in PD pathology, but little is known about αSO formation in vivo and how they induce neurodegeneration. Both the naturally occurring polyunsaturated fatty acid docosahexaenoic acid (DHA) and the lipid peroxidation product 4-hydroxynonenal (HNE), strongly upregulated during ROS conditions, stimulate the formation of αSOs, highlighting a potential role in PD. Yet, insight into αSOs structure and biological effects is still limited as most oligomer preparations studied to date are heterogeneous in composition. Here we have aggregated aSN in the presence of HNE and DHA and purified the αSOs using size exclusion chromatography. Both compounds stimulate formation of spherical αSOs containing anti-parallel β-sheet structure which have the same shape as unmodified αSOs though ca. 2-fold larger. Furthermore, the yield and stabilities of these oligomers are significantly higher than for unmodified aSN. Both modified and unmodified αSOs permeabilize synthetic vesicles, show high co-localisation with glutamatergic synapses and decrease Long Term Potentiation (LTP), in line with the reported synaptotoxic effects of αSOs. We conclude that DHA- and HNE-αSOs are convenient models for pathogenic disease-associated αSOs in PD.
Epidural Catheter Migration: A Comparison of Tunnelling against a New Technique of Catheter Fixation (2003)

We investigated the efficacy of a new technique of epidural catheter fixation that relies on a strip of adhesive foam transfixed by a securing suture. We compared this technique to a tunnelled technique in a prospective, randomized trial (n = 25 in each group). Epidural catheter depth was recorded at the time of insertion and at the time of removal. Clinically significant catheter movement was considered as > 2 cm outward movement or > 1 cm inward movement. The mean duration of epidural analgesia was five days for both groups. Clinically significant movement was noted in eight patients (32%) in the tunnelled group and seven patients (28%) in the sutured group (P = 0.75). Movement of the epidural catheter did not correlate with analgesic failure. The sutured technique provided similar protection against migration to tunnelling but any potential advantages were offset by concerns about a significantly higher incidence of erythema around the catheter exist site in the sutured group (1 vs 6 patients, P = 0.04).
Optimum design of sustainable concrete pavements (2006)

Optimum design of continuously reinforced concrete pavement (CRCP) can produce low-maintenance sustainable pavements with extremely long service lives. The advantages for roads and highways include low whole-life cost, economic and social benefits from reduced fuel consumption and pollution, reduced man-hour wastage, user frustration and aggravation. Unfortunately, the full potential of CRCP is not realised with conventional pavement design. Furthermore, very few successful structurally enhancing bonded concrete overlays (BCOs) at even lower whole-life cost have actually been achieved. This paper focuses on the essential requirements for a long-life sustainable pavement and outlines the essential shortcomings and deficiencies in conventional CRCP design. Optimum design can only be achieved if both a semi-rigid pavement model and a rigid pavement model are considered jointly. Furthermore, the abysmal failures of many BCOs can also be explained and rectified utilising various concepts outlined in this paper. Optimum combinations of fibre and bar reinforcement are also considered for even further advances in the future when more experimental data, especially field data, become available.
Mutations in the FIE and MEA Genes That Encode Interacting Polycomb Proteins Cause Parent-of-Origin Effects on Seed Development by Distinct Mechanisms (2000)

Ramin Yadegari, Tetsu Kinoshita, Ofra Lotan, Gal Cohen, Anat Katz, Yeonhee Choi, Aviva Katz, Kazuo Nakashima, John J. Harada, Robert B. Goldberg, Robert L. Fischer, Nir Ohad, Mutations in the FIE and MEA Genes That Encode Interacting Polycomb Proteins Cause Parent-of-Origin Effects on Seed Development by Distinct Mechanisms, The Plant Cell, Vol. 12, No. 12 (Dec., 2000), pp. 2367-2381
A 25W X-band GaN PA in SMT package (2014)

A single stage X-band (9-10GHz) PA module has been developed using a discrete 0.25um GaN transistor with 4.8mm gate periphery, that incorporates input and output matching via discrete substrates in package. The initial demonstrator module achieves 25W of power under pulsed conditions at 9.5-10GHz with Vds=50V, a peak efficiency of 41% and small signal gain of around 12dB. The PA was assembled in a 6mm overmolded QFN package. The power density and peak drain efficiency are in reasonable agreement with the process pcm performance at this frequency, given output matching losses have to be accounted for. This work demonstrates for the first time the feasibility of prematched GaN transistors and MMIC-like modules in high volume SMT packaging and to a frequency of 10GHz.
The Improvement of Online Arbitration Rules of Evidence in China (2012)

Online arbitration as an emerging method for resolving disputes has variable forms. Within the system, the storage and exchange of the evidence depends greatly on the system environment and the authenticity of the evidence is easily damaged. This paper compares the differences between online arbitration rules of evidence and civil rules of evidence. Then the author analyzes the flaws of online arbitration rules of evidence and proposes ideas of improvement. At last the author summarizes the feature and uniqueness of online arbitration and gives some detailed suggestions from the perspective of technical protection, collection evidence rules as well as supporting measures to online arbitration. Key words: Online arbitration; Rules of evidence; Electronic evidence
Interactive generation of virtual environments using MUAVs (2011)

In this paper we introduce a novel approach to interactively generate a virtual environment (VE) as reconstruction of the real world by using a swarm of autonomously flying miniature unmanned aerial vehicles (MUAVs). In our system each of the MUAVs is equipped with advanced network as well as different sensor technologies, which allow to capture images from low altitudes and to transfer those to a ground station, where the captured environment is reconstructed. At the ground station, the virtual 3D reconstruction is displayed in different virtual reality (VR) environments in which operators can not only explore the VE, but also interactively control the 3D reconstruction process. Therefore, virtual representations of the real MUAVs are visually integrated in the VE according to their real world position and orientation. The operator can manually steer these virtual MUAVs leading to corresponding movements of their real world counterparts. In this paper we introduce the AVIGLE project. In particular, we describe the 3D reconstruction process as well as the rendering of the large amount of data collected by the MUAVs. Furthermore, we outline the VR setup, and explain in detail how operators can interact with the virtual 3D reconstruction and the visual representation of the MUAVs.
Evolutionary Conservation of Developmental Mechanisms (1992)

Wiley-Liss, 1993. $98.00 (xii + 219 pages) ISBN 0 471 58843 1 As we learn more about the mechanisms that control development, it becomes possible to consider how they may have evolved. The title of this volume reflects current interest in the topic. The same is not always true of the articles it contains! Four papers in this compendium do make some serious attempt to consider evolutionary questions. Weisblat and his colleagues spell out the approach most explicitly: 'to understand which embryological phenomena constitute primary characteristics uniting a large group of species, and which are derived characteristics that set apart smaller groups of individual species'. 'What concerns us here', they say, 'is a third level of homology' (beyond the conservation of primary sequence, and the secondary level of conserved biochemical function). This third level is 'the phylogenetic conservation, not just of single genes, but rather of sets of genes interacting with one another in a reciprocal or hierarchical manner'. This approach subsumes a multitude of questions that are ripe for attack, from the specific to the general. Where on the phylogenetic tree do G-protein - coupled transduction mechanisms first appear? What was the primitive role of
High performance connected digit recognition using codebook exponents (1992)

The authors describe the latest developments by the speech research group at CRIM in speaker-independent connected digit recognition, using hidden Markov models (HMMs) trained with maximum mutual information estimation (MMIE). The work presented is a continuation of work previously described by the authors (see Proc. 1991 IEEE Inf. Conf. on Acoust. Speech and Sign. Process., pp.533-536). The main differences are: (1) use of the 20-kHz TI/NIST corpus available on CD-ROM (instead of the 10-kHz distribution tape), (2) use of word models (instead of sub-word units), (3) addition of second derivative parameters, and (4) a more elaborate training procedure for codebook exponents. The experiments described were all performed on the complete adult portion of the corpus. The baseline system, using discrete HMMs and MMIE, has a 0.67% word error rate and a 2.03% string error rate. The authors describe techniques that allowed them to improve greatly the recognition rate.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Patterned wafer segmentation (2003)

This paper is an extension of our previous work on the image segmentation of electronic structures on patterned wafers to improve the defect detection process on optical inspection tools. Die-to-die wafer inspection is based upon the comparison of the same area on two neighborhood dies. The dissimilarities between the images are a result of defects in this area of one of the die. The noise level can vary from one structure to the other, within the same image. Therefore, segmentation is needed to create a mask and apply an optimal threshold in each region. Contrast variation on the texture can affect the response of the parameters used for the segmentation. This paper shows a method to anticipate these variations with a limited number on training samples, and modify the classifier accordingly to improve the segmentation results.