gebhart/patrepeval huggingface dataset:
Thermodynamics and kinetics of protein incorporation into membranes. (1983)

The free energy and enthalpy of protein incorporation into membranes are calculated with special emphasis on the hitherto neglected effects of immobilization of protein and perturbation of lipid order in the membrane. The free energy change is found to be determined by the hydrophobic effect as the driving force for incorporation and the protein immobilization effect which leads to a considerable reduction of the free energy gained from the hydrophobic effect. For incorporation of a hydrophobic, bilayer-spanning alpha-helix, the free energy change obtained is of the order of -15 kcal/mol (1 cal = 4.184 J) in agreement with experimental results. The lipid perturbation effect yields only a small contribution to the free energy change due to an energy/entropy compensation inherent in lipid order. This effect dominates the enthalpy change, giving rise to values on the order of 100 kcal/mol with a pronounced temperature dependence around the lipid phase transition as observed experimentally. The kinetics of protein incorporation are even more strongly affected by the lipid perturbation effect, leading to an abrupt decrease of the rate of incorporation below the lipid phase transition.
On the Design of Social Voting Recommendation Applications (2015)

Voting Advice Applications (VAAs) are online tools that match the policy preferences of voters with the policy positions of political parties or candidates. Designed to enhance the political competence of citizens, VAAs have become increasingly popular and institutionally embedded in a growing number of European countries. While the traditional VAA relied on the stated position or academically coded position of parties/candidates, a recent innovation has been to introduce a social vote recommendation borrowing the basic principles of collaborative filtering. The latter takes advantage of the community of VAA users to provide a vote recommendation. This paper provides an overview of the social vote recommendation scheme and tackles three problems related to its optimal implementation in a real–world setting: (1) the number of samples required to train party models; (2) whether this number is affected by differences in characteristics between early users versus late users; and (3) whether generalizations can be derived across VAA applications in different countries. For our experiments we use three real VAA datasets based on elections in Greece 2012, Cyprus 2013 and Germany 2013. The corresponding datasets are made freely available to other researchers working in the areas of VAA and web based recommender systems.
The natural history of type-specific human papillomavirus infections in female university students. (2003)

Little is known about the average duration of type-specific human papillomavirus (HPV) infections and their patterns of persistence. The objectives of this study were to evaluate the rate of acquisition and clearance of specific HPV types in young women. Female university students (n = 621) in Montreal were followed for 24 months at 6-month intervals. At each visit, a cervical specimen was collected. HPV DNA was detected using the MY09/MY11 PCR protocol followed by typing for 27 HPV genotypes by a line blot assay. The Kaplan-Meier technique was used to estimate the cumulative probability of acquiring or clearing a HPV infection considering types individually or in high-risk (HR) or low-risk (LR) groups defined by oncogenic potential. Incidence rates were 14.0 cases/1000 women-months (95% confidence interval, 11.4-16.3) and 12.4 cases/1000 women-months (95% confidence interval, 10.4-14.8) for acquiring HR and LR HPV infections, respectively. The 24-month cumulative rates of acquisition were highest for HPV-16 (12%), HPV-51, and HPV-84 (8%). Of the incident infections, HPV-16 was the most persistent (mean duration, 18.3 months), followed by HPV-31 and HPV-53 (14.6 and 14.8 months, respectively). HPV-6 and HPV-84 had the shortest mean duration time (<10 months) The mean durations of incident, same-type LR or HR HPV infections were 13.4 months and 16.3 months, respectively. Whereas the majority of episodes with a type-specific HPV infection cleared within 2 years, there were many women who were either reinfected with a new HPV genotype or presumably experienced reactivation of their initial infection.
P-, E-, and L-Selectin Mediate Migration of Activated CD8+ T Lymphocytes into Inflamed Skin (2002)

P- and E-selectin mediate CD4+ Th1 cell migration into the inflamed skin in a murine contact hypersensitivity model. In this model, not only CD4+ T cells but also CD8+ T cells infiltrate the inflamed skin, and the role of CD8+ type 1 cytotoxic T (Tc1) cells as effector cells has been demonstrated. Here we show that in mice deficient in both P- and E-selectin, the infiltration of CD8+ T cells in the inflamed skin is reduced, suggesting the role of these selectins in CD8+ T cell migration. We directly studied the role of selectins using in vitro-generated Tc1 cells. These cells are able to migrate into the inflamed skin of wild-type mice. This migration is partially mediated by P- and E-selectin, as shown by the reduced Tc1 cell migration into the inflamed skin of mice deficient in both P- and E-selectin or wild-type mice treated with the combination of anti-P-selectin and anti-E-selectin Abs. During P- and E-selectin-mediated migration of Tc1 cells, P-selectin glycoprotein ligand-1 appears to be the sole ligand for P-selectin and one of the ligands for E-selectin. P- and E-selectin-independent migration of Tc1 cells into the inflamed skin was predominantly mediated by L-selectin. These observations indicate that all three selectins can mediate Tc1 cell migration into the inflamed skin.
Performance Evaluation of Track-to-track Association and fusion in Distributed Multiple Radar Tracking (2008)

A distributed system for tracking multiple targets with a pair of multifunction radars is proposed and implemented. The system performs track-to-track association and track-to-track fusion at the fusion center to form fused tracks. The association and fusion are performed using target state information linked via communication nodes from a radar at a remote location. Many factors can affect the track-to-track association and fusion performances. They include delays in data transmission buffer of the remote radar, the error in estimating time-stamp of the remote radar, and the gating in track-to-track association. The effects on association and fusion performances due to these factors are investigated through extensive numerical simulations.
The FGFR Landscape in Cancer: Analysis of 4,853 Tumors by Next-Generation Sequencing (2015)

FGFR aberrations are common in a wide variety of cancers, with the majority being gene amplifications or activating mutations. These data suggest that FGFR inhibition could be an important therapeutic option across multiple tumor types.
Complex composition and co‐amplification of <i>SAS</i> and <i>MDM2</i> in ring and giant rod marker chromosomes in well‐differentiated liposarcoma (1994)

Extra abnormal chromosomes (rings and giant rods) containing chromosome 12 sequences are characteristic of well-differentiated liposarcoma (WDLPS). By whole chromosome painting we found in 6 WDLPS that minimally 5 chromosomes had contributed to the formation of the extra abnormal chromosomes. To the constant chromosome 12 contribution, sequences were variably added from chromosomes 1, 4, and 16. Material from chromosomes 1, 4, and 12 was identified by painting in interphase nuclear projections ("blebs") and in micronuclei consistent with the concept that blebs are precursors to micronuclei. The complexity of the mechanisms generating the extra abnormal chromosomes in WDLPS was also attested to by the diversity and, in some cases, intricacy of the patterns of fluorescence. To begin to fathom the function of the extra abnormal chromosomes we examined the amplification of genes, including SAS, MDM2, and GADD153/CHOP, known to be in the region 12q13-14. SAS and MDM2 demonstrated constant co-amplification. GADD153/CHOP, which is critically rearranged in myxoid liposarcoma, was not amplified in WDLPS.
대학생의 조화열정이 주관적 안녕감에 미치는 영향: 그릿(Grit)에 의해 조절된 목표전략적 몰입의 매개효과 (2021)

본 연구는 대학생의 조화열정이 주관적 안녕감에 미치는 영향을 확인하고, 그 관계에서 학습몰입의 하위요인 중 구조화된 행동과 관련한 요인인 목표전략적 몰입의 매개효과가 그릿에 의하여 조절되는지를 검증하고자 하였다. 만 18~25세 남녀 대학생 365명을 대상으로 자기보고식 설문을 실시하였으며, Process Macro 14번 모형 분석을 통해 모델의 유의성을 검증하였다. 그 결과 조화열정, 주관적 안녕감 및 목표전략적 몰입 간 모든 직접 경로가 정적으로 유의하였으며, 조화열정과 주관적 안녕감의 관계에서 목표전략적 몰입을 통한 매개효과 및 그릿의 조절된 매개효과도 모두 유의미한 것으로 검증되었다. 본 연구는 불확실성으로 대표되는 성인진입기 대학생의 주관적 안녕감을 높이기 위한 방안으로 열정을 발휘할 수 있는 활동을 탐색하는 것과 개인의 정체성이 자율적으로 내면화된 조화열정의 추구, 그리고 목표 지향적이고 전략적인 몰입 행동이 중요함을 시사한다. 특히, 장기 목표를 설정하고 일관된 관심사를 갖기 위한 그릿이 발달하는 시기일수록 고도의 몰입이 안녕감을 촉진할 수 있음을 제안하였다는 점에서 의의가 있다.
Detection of P-Glycoprotein in Squamous Cell Carcinomas of the Head and Neck (1993)

One established mechanism of multidrug resistance is elevated expression of P-glycoprotein. The expression of P-glycoprotein by immunohistochemistry was examined in squamous cell carcinomas of the head and neck using a newly developed monoclonal antibody, UIC2, which is specific to the human MDR1 gene product and recognizes an external epitope of the protein. P-glycoprotein was detected in 60% of the samples. MDR1 expression was compared with clinical response to chemotherapy in eight patients who received MDR1-dependent drugs and response was accurately predicted in seven (89%) of eight patients. Positive P-glycoprotein staining correlated with the degree of tumor differentiation, but not with other clinical factors. Therefore, analyzing the expression of P-glycoprotein may play a role when planning chemotherapeutic regimens for patients with head and neck cancer and may be an additional prognostic and diagnostic tool in these patients.
Biaxially aligned buffer layers of cerium oxide, yttria stabilized zirconia, and their bilayers (1997)

Biaxially aligned cerium oxide (CeO2) and yttria stabilized zirconia (YSZ) films were deposited on Ni-based metal (Hastelloy C276) substrates held at room temperature using ion beam assisted (IBAD) magnetron deposition with the ion beam directed at 55° to the normal of the film plane. In addition, we achieved, room-temperature epitaxial growth of CeO2 by bias sputtering to form biaxially aligned CeO2/YSZ bilayers. The crystalline structure and in-plane orientation of films was investigated by x-ray diffraction techniques. Both the IBAD CeO2 and YSZ films, and the CeO2/YSZ bilayers have a (111) pole in the ion beam direction.
Evaluation of Different Die Attach Film and Epoxy Pastes for Stacked Die QFN Package (2007)

The trend in the semiconductor industry is to develop more powerful components while decreasing the component size. A suitable material set has to be obtained for the required reliability performance. The objective of this study is to evaluate the performance of different die attach film (DAF) and epoxy pastes for stacked die Quad Flat No-lead package. Both experimental and modeling works are resorted to analyze and refine the package design. Six combinations of die attach materials are evaluated to compare with current single die package. The strengths and weaknesses of the DAF and epoxy paste are compared in this paper. Die shear test is performed to study the adhesion condition between the die attach material and silicon die. Finite element model of the package is generated to determine the thermally induced stresses under different conditions. All the results show that it is robust to use the new epoxy paste and DAF.
Effect of ATP-MgCl2-glucose administration during hemorrhagic shock on cardiovascular function, metabolism, and survival. (1980)

Both exogenous glucose and adenosine triphosphate--magnesium chloride (ATP-MgCl2, used separately, have been reported to prolong survival after hemorrhagic shock. The purpose of this study was to determine whether intravenously administered glucose plus ATP-MgCl2 given together during hemorrhagic shock would improve cardiac function and survival. Further, we investigated whether glucose had any real additive effect when used in conjunction with ATP-MgCl2, by using ATP-MgCl2 alone and with equimolar mannitol. Awake pigs were bled 40% of total blood volume within 10 minutes. Five pigs received no treatment; 4 received lactated Ringer's equivalent to the initial bled volume; 5 received ATP (206 microM/kg), MgCl2 (206 microM/kg) and glucose (0.5 g/kg); 5 received ATP-MgCl2, glucose and lactated Ringer's; 5 received ATP-MgCl2 alone, and 6 received ATP-MgCl2 and mannitol (0.5 g/kg). All treated groups received sodium bicarbonate (2 mEq/kg). Duration of this experiment was 240 minutes. Mean survival of those which received no treatment was 36.8 +/- SE 2.9 minutes; those which received ATP-MgCl2-glucose had a significantly longer survival with a mean of 157.6 +/- 12.0 minutes (p less than 0.05). With Ringers' alone, the mean survival was 92.6 +/- 0.7 minutes and those which received ATP-MgCl2-glucose plus Ringer's had a significantly greater mean survival of 159-0 +/- 2.7 minutes (p less than 0.05). Mean survival of those which received ATP-MgCl2-mannitol was statistically significantly greater at 200.8 +/- 10.3 minutes than ATP-MgCl2-glucose alone with Ringer's (p less than 0.01). Mean survival was greatest in those which received ATP-MgCl2 alone at 201.2 +/- 9.5 minutes (p less than 0.01), and statistically significantly greater than any other treatment group except ATP-MgCl2-mannitol. ATP-MgCl2 alone significantly increased survival compared to those which received ATP-MgCl2-glucose.
Association of Antioxidants with Memory in a Multiethnic Elderly Sample Using the Third National Health and Nutrition Examination Survey (1999)

Oxidative stress has been implicated both in the aging process and in the pathological changes associated with Alzheimer's disease. Antioxidants, which have been shown to reduce oxidative stress in vitro, may represent a set of potentially modifiable protective factors for poor memory, which is a major component of the dementing disorders. The authors investigated the association between serum antioxidant (vitamins E, C, A, carotenoids, selenium) levels and poor memory performance in an elderly, multiethnic sample of the United States. The sample consisted of 4,809 non-Hispanic White, non-Hispanic Black, and Mexican-American elderly who visited the Mobile Examination Center during the Third National Health and Nutrition Examination Survey, a national cross-sectional survey conducted from 1988 to 1994. Memory is assessed using delayed recall (six points from a story and three words) with poor memory being defined as a combined score less than 4. Decreasing serum levels of vitamin E per unit of cholesterol were consistently associated with increasing levels of poor memory after adjustment for age, education, income, vascular risk factors, and other trace elements and minerals. Serum levels of vitamins A and C, beta-carotene, and selenium were not associated with poor memory performance in this study.
Dynamics and control of robotic systems worn by humans (2002)

A description is given of the dynamics, control, and stability of extenders, robotic systems worn by humans for material handling tasks. Extenders are defined as robot manipulators which extend the strength of the human arm in load maneuvering tasks, while the human maintains control of the task. Part of the extender motion is caused by physical power from the human; the rest of the extender motion results from force signals measured at the physical interfaces between the human and the extender, and the load and the extender. Therefore, the human wearing the extender exchanges both power and information signals with the extender. The control technique described lets the designer define an arbitrary relationship between the human force and the load force. Experiments on a two-dimensional non-direct-drive extender were done to verify the control theory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
NIR Absorbing Squaraines by Extension of the Conjugation with (Aminothiazolyl)ethenyl Groups (2004)

Abstract The bis{4‐{2‐[2‐(dialkylamino)thiazol‐5‐yl]ethenyl}‐2,6‐dihydroxyphenyl}squaraines 12a , b were synthesized from ethyl carbonochloridate ( 1 ) in six steps ( Scheme ). The donor–acceptor–donor systems 12a , b are dark blue dyes with absorption maxima in the NIR region, unless the measurements are performed in the presence of EtOH. In the latter case, the long‐wavelength band disappears, and the absorption in the UV region is strongly enhanced. The λ max values in CHCl 3 and CHCl 3 /EtOH differ by more than 450 nm. The completely reversible effect can be rationalized by the reversible degradation of intramolecular H‐bonds and a consequent torsion between the acceptor and the donor moieties.
Comparación de diseños aproximados de planes de muestreo para la distribución Log-Normal con censura progresiva (2009)

Existen diversos estudios sobre el dise~no de los planes de muestreo en abilidad en el
caso de la censura progresiva. En general, estos dise~nos suelen utilizar resultados basados
en aproximaciones.
Este trabajo considera que la variable que mide el tiempo de vida de una unidad de
un producto determinado sigue una distribucion log-normal. Se obtienen varios dise~nos
aproximadamente optimos que utilizan los estimadores de maxima verosimilitud as como
los mejores estimadores lineales insesgados de los parametros de la distribucion en la
determinacion del criterio clasico de aceptacion de un lote de productos. Para evaluar el
grado de correccion de estos dise~nos aproximados, se calculan mediante simulacion los
riesgos correspondientes y se comparan con las especicaciones jadas por el productor y
el consumidor. Los resultados se presentan en forma de tablas y gracos ilustrativos que
permiten escoger los dise~nos que mejor se ajustan a dichas especicaciones.
Pectate lyase 10A from Pseudomonas cellulosa is a modular enzyme containing a family 2a carbohydrate-binding module (2001)

Pectate lyase 10A (Pel10A) enzyme from Pseudomonas cellulosa is composed of 649 residues and has a molecular mass of 68.5kDa. Sequence analysis revealed that Pel10A contained a signal peptide and two serine-rich linker sequences that separate three modules. Sequence similarity was seen between the 9.2kDa N-terminal module of Pel10A and family 2a carbohydrate-binding modules (CBMs). This N-terminal module of Pel10A was shown to encode an independently functional module with affinity to crystalline cellulose. A high sequence identity of 66% was seen between the 14.2kDa central module of Pel10A and the functionally uncharacterized central modules of the xylan-degrading enzymes endoxylanase 10B, arabinofuranosidase 62C and esterase 1D, also from P. cellulosa. The 35.8kDa C-terminal module of Pel10A was shown to have 30 and 36% identities with the family 10 pectate lyases from Azospirillum irakense and an alkaliphilic strain of Bacillus sp. strain KSM-P15, respectively. This His-tagged C-terminal module of the Pel10A was shown to encode an independent catalytic module (Pel10Acm). Pel10Acm was shown to cleave pectate and pectin in an endo-fashion and to have optimal activity at pH10 and in the presence of 2mM Ca2+. Highest enzyme activity was detected at 62°C. Pel10Acm was shown to be most active against pectate (i.e. polygalacturonic acid) with progressively less activity against 31, 67 and 89% esterified citrus pectins. These data suggest that Pel10A has a preference for sequences of non-esterified galacturonic acid residues. Significantly, Pel10A and the P. cellulosa rhamnogalacturonan lyase 11A, in the accompanying article [McKie, Vincken, Voragen, van den Broek, Stimson and Gilbert (2001) Biochem. J. 355, 167–177], are the first CBM-containing pectinases described to date.
Singular Point Detection in Fingerprint Image (2002)

Singular point detection is an important task in many Automatic Fingerprint Identification Systems (AFIS). There already exists many singular point detection algorithms, Most of them can efficiently detect the core point when the image quality is fine, but when the image quality is poor, the efficient of the algorithm degrades rapidly. In this paper, we present a new singular point detecting algorithm based on Multi-Resolution Direction Field (DF). First we use the low resolution DF to find an area that includes singular point, then we use high resolution direction field to search the precise position of the singular point. Experiment results show that the detection precise is rather high, even with a poor quality image.
Identification and characterization of differentiation mutants in the protozoan parasite <i>Toxoplasma gondii</i> (2002)

Two forms of the protozoan parasite Toxoplasma gondii are associated with intermediate hosts such as humans: rapidly growing tachyzoites are responsible for acute illness, whereas slowly dividing encysted bradyzoites can remain latent within the tissues for the life of the host. In order to identify genetic factors associated with parasite differentiation, we have used a strong bradyzoite-specific promoter (identified by promoter trapping) to drive the expression of T. gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase (HXGPRT) in stable transgenic parasites, providing a stage-specific positive/negative selectable marker. Insertional mutagenesis has been carried out on this parental line, followed by bradyzoite induction in vitro and selection in 6-thioxanthine to identify misregulation mutants. Two different mutants fail to induce the HXGPRT gene efficiently during bradyzoite differentiation. These mutants are also defective in other aspects of differentiation: they replicate well under bradyzoite growth conditions, lysing the host cell monolayer as effectively as tachyzoites. Expression of the major bradyzoite antigen BAG1 is reduced, and staining with Dolichos biflorus lectin shows reduced cyst wall formation. Microarray hybridizations show that these mutants behave more like tachyzoites at a global level, even under bradyzoite differentiation conditions.
Compact equivalent circuit model for the skin effect (2002)

Rules for determining a compact circuit model consisting of four resistors and three inductors to accurately predict the skin effect have been developed. The circuit is easily constructed from the geometry, producing a response that matches exact results over a frequency range from dc to very high frequencies.