gebhart/patrepeval huggingface dataset:
Distinct Cloned Class II MHC DNA Binding Proteins Recognize the X Box Transcription Element (1988)

The class II (Ia) major histocompatibility complex (MHC) antigens are a family of integral membrane proteins whose expression is limited to certain cell types. A pair of consensus sequences, X and Y, is found upstream of all class II genes, and deletion of each of these sequences eliminates expression of transfected genes. Furthermore, the absence of a specific X box binding protein in patients with severe combined immunodeficiency disease whose cells lack class II suggests an important role for these proteins in class II regulation. Here, the cloning of two lambda gt11 complementary DNAs encoding DNA binding proteins (murine X box binding proteins lambda mXBP and lambda mXBP-2) is reported. Both phage-encoded fusion proteins bind specifically to the X box of the A alpha, but not to E alpha or E beta class II genes. These two independent isolates do not cross-hybridize. The lambda mXBP complementary DNA hybridizes to two RNA species, 6.2 and 3.0 kilobases in mouse, that are expressed in both Ia positive and Ia negative cells. By means of DNA blot analysis with the lambda mXBP complementary DNA insert and probes generated from each end of this complementary DNA insert, lambda mXBP was found to arise from a multigene family. These data illustrate the high degree of complexity in the transcriptional control of this coordinately regulated gene family.
On sizing CCN content stores by exploiting topological information (2012)

In this work, we study the caching performance of Content Centric Networking (CCN), with special emphasis on the size of individual CCN router caches. Specifically, we consider several graph-related centrality metrics (e.g., betweenness, closeness, stress, graph, eccentricity and degree centralities) to allocate content store space heterogeneously across the CCN network, and contrast the performance to that of an homogeneous allocation.
Vibration damping in polygonal plates using the acoustic black hole effect : model based on the image source method (2012)

A method for damping flexural vibrations in thin polygonal plates using the acoustic black hole effect is proposed. Acoustic black holes in thin plates consist of a zone of decreasing thickness in which flexural waves slow down, acting as wave sinks. An acoustic black hole of axisymmetric thickness profile is here tested on different polygonal plates. A parabolic edge is added in order to focus waves into the black hole area. The experimental results show significant reduction of the vibration level. A model based on the image source method provides qualitative agreement with the experiments.
Charles Babbage's Analytical Engine, 1838 (1982)

Charles Babbage commenced work on the design of the Analytical Engine in 1834 following the collapse of the project to build the Difference Engine. His ideas evolved rapidly, and by 1838 most of the important concepts used in his later designs were established. This paper introduces the design of the Analytical Engine as it stood in early 1838, concentrating on the overall functional organization of the mill (or central processing portion) and the methods generally used for the basic arithmetic operations of multiplication, division, and signed addition. The paper describes the working of the mechanisms that Babbage devised for storing, transferring, and adding numbers and how they were organized together by the "microprogrammed" control system; the paper also introduces the facilities provided for user- level programming. The intention of the paper is to show that an automatic computing machine could be built using mechanical devices, and that Babbage's designs provide both an effective set of basic mechanisms and a workable organization of a complete machine.
Synthesis and properties of unsaturated polyester diol–polyurethane hybrid polymer network (1994)

Abstract This article deals with the synthesis and properties of poly[(propylene glycol maleate)‐ co ‐(propylene glycol phthalate)] diol (PGMPD)/polyester–urethane or polyether–urethane hybrid polymer networks (HPNs). The polyurethane type and the molar ratio of NCO/OH have an effect on their properties. The structure–property relationship is discussed as well. © 1994 John Wiley & Sons, Inc.
Ribosomal ambiguity (<i>ram</i>) mutations facilitate dihydrostreptomycin binding to ribosomes (1979)

4) control codes (e.g. ) Can I get you anything? ? All right. Which of you will carry this? Thank you Are you going to equip it here? Would you like me to buy the for $? cannot equip this. Do you still want to buy it? Please come again.\nExcuse me, uhhh&#8230; you don&#8217;t seem to have enough money. I&#8217;m afraid you cannot carry anything else. Do you want to sell some things that you don&#8217;t need? What do you want to sell? ? I can buy it for $. Would you like to do that? Please come ...
A 3-5.5 V CMOS 32 Mb/s fully-integrated read channel for disk-drives (2002)

A low-power (300-mW), 10-32-Mb/s fully integrated CMOS read-channel IC that can operate from a single 3-5.5-V supply for battery-operated disk drive applications has been developed. The chip includes an automatic gain control (AGC), a programmable 3.5-16-MHz sixth-order linear-phase equalization filter, a servo demodulator, a pulse detector, a frequency synthesizer, data separator, and an encoder/decoder. The architecture of the chip provides a high degree of programmability for zoned-recording and embedded-servo operation, switching between servo and data mode characteristics in less than 1 /spl mu/s, and uses a reduced number of external passive components (eight capacitors and five resistors).
<title>High-resolution UV laser repair of phase-shifting photomasks</title> (1994)

Processes for repairing defects on phase shifting masks have been developed at Excel/Quantronix. The processes are based on DUV (248 nm) laser ablation and DUV laser- assisted chemical vapor deposition. The light source of the repair system consists of a gain- switched Ti:Sapphire laser system. The 248 nm wavelength is obtained by frequency tripling. The all-solid-state laser provides high stability, short pulse duration, and good beam quality required by the repair processes. By significantly improving the optical system, we are capable of repairing features with a diameter of approximately 0.2 micrometers . The repair of programmed defects such as 0.5 X 0.5 micrometers <SUP>2</SUP> extra quartz phase shifter (with or without chrome on top) and 1 X 1 micrometers <SUP>2</SUP> phase divots have been successfully demonstrated and examined by the aerial image measurement system (AIMS) developed by IBM. After opaque defect repair, the repaired area exhibits a transmission greater than 95% for both I-line and 248 nm. Clear defects are repaired in an open-air environment with controlled transmission. The deposited films show good uniformity and sharp edges. Extra quartz phase shifter defects are reliably repaired in an open-air environment with the technique of laser ablation by surface enhancement (LASE), which was developed at Excel/Quantronix. Phase divots have been successfully repaired by photolytic deposition of SiO<SUB>2</SUB> in a vacuum system using a single precursor, without the need of an oxidizing co-reactant. The repair techniques developed by Excel/Quantronix have broad applicability to a wide variety of conventional and phase shifting photomasks.
Osgood-Schlatter Disease: Practical Treatment for a Self-Limiting Condition (2010)

Osgood-Schlatter disease is one of the most common causes of knee pain in active adolescents. It is a generally benign disturbance at the junction of the patellar tendon and the tibial tubercle apophysis, and treatment during its 12- to 24-month course should be matched to severity. Mild symptoms require only patient education and moderation of activity, but severe symptoms call for a period of rest (or, rarely, immobilization) followed by aggressive quadriceps strengthening. Other conditions such as Sinding-Larsen-Johansson disease may occur simultaneously, and long-term effects can include a prominence on the anterior knee or painful kneeling.
Fault Diagnosis of Centrifugal Pumps Using Motor Electrical Signals (2012)

Centrifugal Pumps 16 motor-pump system that is faulty. The unique contribution of this work is that it uses only the motor electrical signals to detect and isolate faults in the motor and the pump. Moreover, it does not presume the existing "health" condition of either the motor or the pump and detects the degradation of the system from the current state.
Alveolar pressure nonhomogeneity during small-amplitude high-frequency oscillation (1984)

In six excised canine lungs, regional alveolar pressures (PA) were measured during small-amplitude high-frequency oscillations applied at the airway opening. Both the regional distribution of PA's and their relationship to pressure excursions at the airway opening (Pao) were assessed in terms of amplitude and phase. PA was sampled in several capsules glued to the pleural surface and communicating with alveolar gas via pleural punctures. Pao and PA were measured over the frequency (f) range 1-60 Hz, at transpulmonary pressures (PL) of 5, 10, and 25 cmH2O. The amplitude of PA excursions substantially exceeded Pao excursions at frequencies near the resonant frequency. At resonance the ratio [PA/Pao] was 1.9, 2.9, and 4.8 at PL's of 5, 10, and 25 cmH2O, respectively. Both spatial homogeneity and temporal synchrony of PA's between sampled lung regions decreased with f and increased with PL. Interregional variability of airway impedance [(Pao - PA)/Vao] and tissue impedance (PA/Vao) tended to be larger than differences due to changing PL but not as large as between-dog variability. These data define the baseline nonhomogeneity of the normal canine lung and also suggest that there may be some advantage in applying high-frequency ventilation at frequencies at least as high as lung resonant frequency.
Favorable clinical outcome of cervical cancers infected with human papilloma virus type 58 and related types (1999)

To determine whether the status of human-papillomavirus (HPV) infection affects the clinical outcome of cervical carcinoma (CC), HPV genotype was prospectively determined in 94 consecutive CC cases subsequently followed for a median duration of 37.5 months. With a consensus PCR-RFLP method of HPV genotyping, 81 (86.2%) cancers were positive for HPV DNA. They were classified, according to the phylogenic similarities, into HPV-16-related (type 16, n = 45; type 31, n = 2), HPV-58-related (type 58, n = 17; type 33, n = 3; type 52, n = 2) and HPV-18-related (type 18, n = 8; type 68, n = 1) groups, and analyzed in relation to clinical outcome. The following results were observed: (i) Type-58-related HPVs were more prevalent in the old age (older than the median age of 52) group than in the young age group (41% vs. 14.6%, p = 0.045); (ii) 63% (5/8) of patients with advanced stages (III and IV) were HPV-negative, a figure much higher than that (9.3%, 8/84) of patients with early stages (stage I and II) (p = 0.002); (iii) the occurrence of adenocarcinoma or adenosquamous carcinoma was higher in the HPV-18-related group (50%) than in the HPV-16-related (33.3%) or the HPV-58-related (16.7%) groups (p = 0.024); (iv) the status of lymph-node metastasis and tumor grade did not correlate with HPV status; (v) 5-year survival rates were 90.2%, 80% and 74% for HPV-58-, HPV-16- and HPV-18-related groups, respectively (p = 0.03, after adjustment for tumor stage); (vi) in comparison with the HPV-16-related group, the relative risk of death in the HPV-58- and the HPV-18-related groups were 0.32 [95% CI, 0.07-1.49] and 1.87 [0.36-14.9] respectively. HPV genotype appears to affect the clinical behavior and outcome of cervical cancer. HPV-58-related types are prevalent in the older population, and appear to confer a favorable prognosis. Int. J. Cancer (Pred. Oncol.) 84:553-557, 1999.
Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors (2016)

In this study, we analyzed RNA-sequencing data of 14 samples characterized by biallelic CEBPA (CEBPA(bi)) mutations included in the Leucegene collection of 415 primary acute myeloid leukemia (AML) specimens, and describe for the first time high frequency recurrent mutations in the granulocyte colony-stimulating factor receptor gene CSF3R, which signals through JAK-STAT proteins. Chemical interrogation of these primary human specimens revealed a uniform and specific sensitivity to all JAK inhibitors tested irrespective of their CSF3R mutation status, indicating a general sensitization of JAK-STAT signaling in this leukemia subset. Altogether, these results identified the co-occurrence of mutations in CSF3R and CEBPA in a well-defined AML subset, which uniformly responds to JAK inhibitors and paves the way to personalized clinical trials for this disease.
High‐pressure Induced Phase Transition in ZrO <sub>2</sub> (1968)

Tetragonal ZrO 2 can be formed directly from the mono‐clinic form at 25° C by applying pressures greater than 37 kbars. The transition is reversible, and the tetragonal phase cannot be retained in a metastable condition at ambient conditions.
A Summary of Extraction, Synthesis, Properties, and Potential Uses of Juglone: A Literature Review (2013)

This literature review summarizes the state of current information on the extraction, synthesis, properties, and potential uses of juglone, a natural product produced by the walnut tree (Juglandacea). Juglone (5-hydroxy-1,4-naphthoquinone) is known primarily for its allelopathic effect against certain plants and toxicity towards marine organisms. It has a wide variety of potential uses in medicine, and as a biocide for organic farming and pest control. This summary also provides historical uses of juglone and the walnut tree, a brief background on the biosynthesis and mode of toxicity of juglone. We further go on to recommend and outline the most common methodologies for extraction of the compound in the academic and small industrial setting.
Heat Transfer Effects During Solidification of Semicrystalline Polymers (1993)

The build-up of the residual stresses in the plastic parts are directly affected by the transient temperature distribution during the solidification stage of the semicrystalline polymers. Hence for crystallizable polymers, it is important to couple the crystallization kinetics with the transport of heat flow to determine the thermal history during solidification. In this paper, an experimental study of solidification of two semi-crystalline polymers under quiescent conditions is carried out to examine the influence of crystallization kinetics on the thermal history. The selected model materials are Nylon-66 and Poly Ethylene Terephalate (PET). The temperature profiles and the location of the solidification front are recorded during the cooling process. The experimental results are compared with the classical heat diffusion model and also with a numerical approach which couples the crystallization kinetics to the heat diffusion equation by modifying the phase change temperature based on the overall cooling rate in the crystalline domain. The front movement and the solidification temperature predictions of the coupled model are in good agreement with the experimental observations.
Mechanism of the mutagenic action of hydroxylamine. VIII. Functional properties of the modified adenosine residues. (1975)

The action of O-methylhydroxylamine in vitro upon some amber and rII ochre mutants of T4 phage leads to a considerable increase in the frequency of reversions and conversions of ochre and opal mutants presumably due to A yields G transitions. The transitions seem to be caused by modification of the adenine bases of the genome to give N-6-methoxyadenine which has equivocal (A- and G-like) specificity. However, the functional activity of N-6-methoxyadenosine residues in the RNA polymerase system is low. We failed to detect any significant activity of these residues either as components of a template polyribonucleotide, or as nucleoside triphosphate precursors.
Pregnancy: Interactions between the embryo and corpus luteum (1993)

A total of 102 patients who had become pregnant following in-vitro fertilization (IVF) and embryo transfer were studied at weekly intervals between 4 and 14 weeks gestation. The pregnancies were classified as follows: (i) normal singleton, n = 52; (ii) normal twin, n = 24; (iii) heterotopic, n = 4 (weeks 4-8 only); and (iv) anembryonic with a viable intra-uterine singleton, n = 22. The serum concentrations of human chorionic gonadotrophin (hCG), Schwangerschaft protein-1 (SP-1) and pregnancy-associated plasma protein-A (PAPP-A), oestradiol and progesterone were measured. The mean serum concentrations of HCG, SP-1 and PAPP-A were significantly less in heterotopic than in singleton, singleton/anembryonic or twin pregnancies (P < 0.01-0.05), while those of progesterone and oestradiol were not different at any time. There were no significant differences between the serum concentrations of any of the substances analysed in singleton/anembryonic and singleton pregnancies, but the concentrations of all the substances analysed were significantly greater in twin pregnancies from as early as 7 weeks (P < 0.01-0.05). These data show that in heterotopic pregnancies trophoblast function is reduced, as suggested by the lower concentrations of the placental proteins. Despite this the concentrations of oestradiol and progesterone, derived predominantly from the corpus luteum between 4 and 8 weeks, are equivalent to those found in twin pregnancies, and greater than those found in singleton and singleton/anembryonic pregnancies. These findings support the notion that although HCG may rescue the corpus luteum it does not subsequently have a direct effect on its function, and suggest that the embryo may influence corpus luteum function.
Shape preserving local contrast enhancement (2002)

A novel approach for shape preserving contrast enhancement is presented. Contrast enhancement is achieved by means of a local histogram equalization algorithm which preserves the level-sets of the image. This basic property is violated by common local schemes, thereby introducing spurious objects and modifying the image information. The scheme is based on equalizing the histogram in all the connected components of the image, which are defined based on the image grey-values and spatial relations between its pixels. Following mathematical morphology, these constitute the basic objects in the scene. We give examples for both grey-valued and color images.
The Anti-inflammatory Activity of <i>Scutellaria rivularis</i> Extracts and Its Active Components, Baicalin, Baicalein and Wogonin (1996)

Five extracts (n-hexane, chloroform, ethyl acetate, n-butanol and water) of Scutellaria rivularis Benth. were evaluated for their anti-inflammatory activity against carrageenan-induced paw edema in rats and compared with indomethacin. The result indicated that chloroform extract proved to be the most effective in all of the extracts. Consequently, three major components (baicalin, baicalein and wogonin) of the chloroform extract were further tested for their anti-inflammatory activity using the same model. It was found that baicalin exhibits the greatest inhibition activity against carrageenan-induced rat paw edema.
Fabrication and Evaluation of Porous Keratin/chitosan (KCS) Scaffolds for Effectively Accelerating Wound Healing. (2015)

The porous KCS scaffold may be used as implanted scaffold materials for promoting wound healing and skin regeneration.
H.264/AVC interpolation optimization (2006)

This paper discusses the optimization of the H.264/AVC sub-pixel interpolation operation in the context of a software implementation on a subword parallel processor. Several known algorithmic and architectural optimization approaches are combined to achieve a low-cost interpolation implementation. The proposed interpolation scheme, which produces identical results with the reference software, requires no multiplications and 16-bit integer arithmetic is sufficient for the computation. The instruction set extensions result in cycle savings without much increasing the hardware cost. They also enable in-place processing in the half-pixel interpolation. When the optimizations are applied, it is possible to implement the H.264/AVC decoder without a multiplier.
Bacteraemia caused by <i>Anaerotruncus colihominis</i> and emended description of the species (2006)

Although the source of the bacteraemia in the patient cannot be determined, this report suggests that A colihominis is of clinical significance. Spore formation is proposed as an emended description of A colihominis.
Sevoflurane Mimics Ischemic Preconditioning Effects on Coronary Flow and Nitric Oxide Release in Isolated Hearts  (1999)

Preconditioning with sevoflurane, like IPC, improves not only postischemic contractility, but also basal flow, bradykinin and nitroprusside-induced increases in flow, and effluent [NO] in isolated hearts. The protective effects of both SPC and IPC are reversed by K(ATP) channel antagonism.
Synthesis and studies of new optimised chelating agents for targeting chemokine receptor CXCR4 (2012)

L objectif de ce travail de thèse était de développer des outils pour détecter et traiter le cancer àun stade précoce. Nous avons donc entrepris la synthèse de nouveaux radiopharmaceutiques ciblantspécifiquement le récepteur CXCR4, en utilisant le savoir-faire et l'expertise de notre groupe dans lasynthèse et la fonctionnalisation des polyazacycloalcanes. Nous avons travaillé simultanément surdeux aspects : l agent chélatant et la molécule vectrice.Dans un premier temps, les travaux ont concerné la conception, la synthèse et la caractérisationde nouveaux macrocycles à fort potentiel pour la chélation du cuivre et du gallium. Nous avons toutd abord développé une nouvelle voie de synthèse permettant d accéder à des dérivés homocyclènesC-functionnalisés. Nous nous sommes ensuite intéressés aux dérivés du 1,4,7-triazacyclononane(TACN). En optimisant une voie de synthèse déjà développée au laboratoire, nous avons facilitél accès à des dérivés TACN N- et C-fonctionnalisés. Nous avons ainsi préparé une série denouveaux agents chélatants bifonctionnels adaptés pour la complexation du cuivre ou du gallium, envariant la nature de la fonction de greffage et des bras coordinants. Nous avons également réalisé lasynthèse de nouveaux cryptands en série cyclène et nous avons étudié leur propriété decomplexation vis à vis du cuivre.Dans un second temps, nous avons développé une nouvelle famille d agents imageants duCXCR4 en modifiant la structure des AMD3100 et AMD3465. Ce travail a tout d abord nécessité lamise au point de nouvelles méthodes de fonctionnalisation de ces structures. Nous avons ainsi pupréparer de nouveaux synthons porteur d une fonction de greffage dans les deux séries. Nous avonsensuite introduit différentes sondes imageantes, telles que des chélates adaptés pour la complexationdu cuivre, gallium et indium ainsi que des sondes fluorescentes de type bodipy
Asymmetric Synthesis of the cis‐ and trans‐Stereoisomers of 4‐Aminopyrrolidine‐3‐carboxylic Acid and 4‐Aminotetrahydrofuran‐3‐carboxylic Acid. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.