gebhart/patrepeval huggingface dataset:
A Differential Geometric Approach to Automated Segmentation of Human Airway Tree (2010)

Airway diseases are frequently associated with morphological changes that may affect the physiology of the lungs. Accurate characterization of airways may be useful for quantitatively assessing prognosis and for monitoring therapeutic efficacy. The information gained may also provide insight into the underlying mechanisms of various lung diseases. We developed a computerized scheme to automatically segment the 3-D human airway tree depicted on computed tomography (CT) images. The method takes advantage of both principal curvatures and principal directions in differentiating airways from other tissues in geometric space. A "puzzle game" procedure is used to identify false negative regions and reduce false positive regions that do not meet the shape analysis criteria. The negative impact of partial volume effects on small airway detection is partially alleviated by repeating the developed differential geometric analysis on lung anatomical structures modeled at multiple iso-values (thresholds). In addition to having advantages, such as full automation, easy implementation and relative insensitivity to image noise and/or artifacts, this scheme has virtually no leakage issues and can be easily extended to the extraction or the segmentation of other tubular type structures (e.g., vascular tree). The performance of this scheme was assessed quantitatively using 75 chest CT examinations acquired on 45 subjects with different slice thicknesses and using 20 publicly available test cases that were originally designed for evaluating the performance of different airway tree segmentation algorithms.
Cryptographic Protocols to Prevent Spam. (2005)

r example, spammers may add spaces or other special characters between letters, or inject intentional, minor spelling errors (Viiagrra). Spamming wastes considerable machine and human resources - most notably, the recipient&apos;s time. Indeed, spamming is reducing the usefulness of email as a communication mechanism these days. Many users reduce or avoid the use of email, most users limit the distribution of their email address, and many desirable messages are lost by aggressive (human and automated) filtering. As a result, there are many proposals and mechanisms trying to control and prevent spam. Spam can be a problem in any open, e#cient, low-cost messaging system, and indeed spam is used e.g. in instant messaging; most of our discussion is relevant to spam on any messaging technology. However, the problem is most acute, at least so far, for email, and therefore we will discuss also some email specific issues. We begin this manuscript by discussing the basic architecture and relevant
Application of PARAFAC2 to fault detection and diagnosis in semiconductor etch (2001)

Abstract Monitoring and fault detection of batch chemical processes are complicated by stretching of the time axis, resulting in batches of different length. This paper offers an approach to the unequal time axis problem using the parallel factor analysis 2 (PARAFAC2) model. Unlike PARAFAC, the PARAFAC2 model does not assume parallel proportional profiles, but only that the matrix of profiles preserves its ‘inner product structure’ from sample to sample. PARAFAC2 also allows each matrix in the multiway array to have a different number of rows. It has previously been demonstrated how the PARAFAC2 model can be used to model chromatographic data with retention time shifts. Fault detection and, to a lesser extent, diagnosis in a semiconductor etch process are considered in this paper. It is demonstrated that PARAFAC2 can effectively model batch process data from semiconductor manufacture with unequal dimension in one of the orders, such as the unequal batch length problem. It is shown that the PARAFAC2 model has approximately the same sensitivity to faults as other competing methods, including principal component analysis (PCA), unfold PCA (often referred to as multiway PCA), trilinear decomposition (TLD) and conventional PARAFAC. The advantage of PARAFAC2 is that it is easier to apply than MPCA, TLD and PARAFAC, because unequal batch lengths can be handled directly rather than through preprocessing methods. It also provides additional diagnostic information: the recovered batch profiles. It is likely, however, that it is less sensitive to faults than conventional PARAFAC. Copyright © 2001 John Wiley & Sons, Ltd.
Preoperative tissue diagnosis for tumours of the pancreas (2008)

Biopsy of suspected pancreatic malignancies with systemic spread or local irresectability is indicated for planning palliative or neoadjuvant therapy. Preoperative biopsy of potentially resectable pancreatic tumours is not generally advisable, as malignancy cannot be ruled out with adequate reliability.
Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability (2018)

Vascular leakage is one of the salient characteristics of severe dengue. Nonstructural protein 1 (NS1) of dengue virus (DENV) can stimulate endothelial cells to secrete endothelial hyperpermeability factor, macrophage migration inhibitory factor (MIF), and the glycocalyx degradation factor heparanase 1 (HPA-1). However, it is unclear whether MIF is directly involved in NS1-induced glycocalyx degradation. In this study, we observed that among NS1, MIF and glycocalyx degradation-related molecules, the HPA-1, metalloproteinase 9 (MMP-9) and syndecan 1 (CD138) serum levels were all increased in dengue patients, and only NS1 and MIF showed a positive correlation with the CD138 level in severe patients. To further characterize and clarify the relationship between MIF and CD138, we used recombinant NS1 to stimulate human cells in vitro and challenge mice in vivo. Our tabulated results suggested that NS1 stimulation could induce human endothelial cells to secrete HPA-1 and immune cells to secrete MMP-9, resulting in endothelial glycocalyx degradation and hyperpermeability. Moreover, HPA-1, MMP-9, and CD138 secretion after NS1 stimulation was blocked by MIF inhibitors or antibodies both in vitro and in mice. Taken together, these results suggest that MIF directly engages in dengue NS1-induced glycocalyx degradation and that targeting MIF may represent a possible therapeutic approach for preventing dengue-induced vascular leakage.
An antibody specific for the C-terminal tail of the gp41 transmembrane protein of human immunodeficiency virus type 1 mediates post-attachment neutralization, probably through inhibition of virus–cell fusion (2005)

Evidence has been presented which shows that part of the C-terminal tail of the gp41 transmembrane protein of human immunodeficiency virus type 1 (HIV-1) contains a neutralization epitope and is thus exposed on the external surface of the virion. Here, SAR1, a monoclonal antibody, which was stimulated by immunization with a plant virus expressing 60 copies of the GERDRDR sequence from the exposed gp41 tail, and has an unusual pattern of neutralization activity, giving little or no neutralization of free virions, but effecting modest post-attachment neutralization (PAN) of virus bound to target cells was investigated. Here, the properties of PAN were investigated. It was found that PAN could be mediated at 4 or 20 degrees C, but that at 20 degrees C maximum PAN required virus-cell complexes to be incubated for 3 h before addition of antibody. Further PAN appeared stable at 20 degrees C and could be mediated for at least 5 h at this temperature. In contrast, when virus-cell complexes formed at 20 degrees C but then shifted to 37 degrees C for various times before addition of SAR1, PAN was maximal after just 10 min, and was lost after 30 min incubation. Thus, PAN at 37 degrees C is transient and temperature-dependent. Since this scenario recalled the temperature requirements of virus-cell fusion, fusion of HIV-1-infected and non-infected cells was investigated, and it was found that SAR1 inhibited this process by up to 75 %, in a dose-dependent manner. However, antibodies to adjacent epitopes did not inhibit fusion. These data confirm the external location of the SAR1 epitope, implicate the gp41 C-terminal tail in the HIV-1 fusion process for the first time, and suggest that SAR1 mediates PAN by inhibiting virus-mediated fusion.
No Multiplication? No Floating Point? No Problem! Training Networks for Efficient Inference (2018)

For successful deployment of deep neural networks on highly--resource-constrained devices (hearing aids, earbuds, wearables), we must simplify the types of operations and the memory/power resources used during inference. Completely avoiding inference-time floating-point operations is one of the simplest ways to design networks for these highly-constrained environments. By discretizing both our in-network non-linearities and our network weights, we can move to simple, compact networks without floating point operations, without multiplications, and avoid all non-linear function computations. Our approach allows us to explore the spectrum of possible networks, ranging from fully continuous versions down to networks with bi-level weights and activations. Our results show that discretization can be done without loss of performance and that we can train a network that will successfully operate without floating-point, without multiplication, and with less RAM on both regression tasks (auto encoding) and multi-class classification tasks (ImageNet). The memory needed to deploy our discretized networks is less than one third of the equivalent architecture that does use floating-point operations.
Estimation of Work of Breathing from Respiratory Muscle Activity In Spontaneous Ventilation: A Pilot Study (2019)

Work of breathing (WOB) offers information that may be relevant to determine the patient’s status under spontaneous mechanical ventilation in Intensive Care Unit (ICU). Nowadays, the most reliable technique to measure WOB is based on the use of invasive catheters, but the use of qualitative observations such as the level of dyspnea is preferred as a possible indicator of WOB level. In this pilot study, the activity of three respiratory muscles were recorded on healthy subjects through surface electromyography while they were under non-invasive mechanical ventilation, using restrictive and obstructive maneuvers to obtain different WOB levels. The respiratory pattern between restrictive and obstructive maneuvers was classified with the Nearest Neighbor Algorithm with a 91% accuracy and a neural network model helped classify the samples into three WOB levels with a 89% accuracy, Low: [0.3–0.8) J/L, Medium: [0.8–1.3] J/L and Elevated: (1.3–1.8] J/L, demonstrating the relationship between the respiratory muscle activity and WOB. This technique is a promising tool for the healthcare staff in the decision-making process when selecting the best ventilation settings to maintain a low WOB. This study identified a model to estimate the WOB in different ventilatory patterns, being an alternative to invasive conventional techniques.
Successful Treatment of Bone Marrow Failure in Gaucher's Disease with Low-dose Modified Glucocerebrosidase (1992)

We report the beneficial effects of enzyme replacement therapy with mannose-terminated human glucocerebrosidase ('Ceredase') in a patient suffering from transfusion-dependent bone marrow failure due to Gaucher's disease. Treatment with low-dose enzyme infusions, given twice weekly, rapidly reversed the haematopoietic failure and incapacitating skeletal disease. It appears likely that prior splenectomy favourably influenced the response to this therapy.
Evidence for an association between hookworm infection and cognitive function in Indonesian school children (1999)

The association between helminth infection and cognitive and motor function was investigated in school-age children in Java, Indonesia. 432 children from 42 primary schools participated in the study. Children were stratified by age and sex into two age groups, 8-9 years and 11-13 years. Children infected with hookworm performed significantly worse than children without hookworm infection in 6 of the 14 cognitive or motor tests. After controlling for school (as a random effect) plus age, socio-economic status and parental education, sex, stunting (height-for-age < - 2sd), body mass index, haemoglobin concentration and the presence of A. lumbricoides and T. trichiura infections, infection with hookworm explained significantly lower scores on tests of Fluency (P < 0.01), Digit-Span Forwards (P < 0.01), Number Choice (P < 0.01), Picture Search (P < 0.03), Stroop Colour Word (P < 0.02) and Mazes (P < 0.001). In 4 of the 6-tests (Fluency, Number Choice, Picture Search and Mazes), there was a significant interaction between hookworm infection and age (P < 0.03), indicating that the association between hookworm and lower test scores increased with age. No associations were observed between hookworm infection and scores in tests of Digit-Span Backwards, Corsi-Block, Stroop Colour, Stroop Interference, Free Recall, Verbal Analogies, Bead Threading or the Pegboard (P > 0.05). Tests associated with helminths represented various functions of working memory. No significant associations between helminth infection and motor function were observed that could not be explained by chance. The results suggest that hookworm infection can have a significant adverse effect on children's working memory which may have consequences for a child's reasoning ability and reading comprehension. Although the results are only associational, the fact that differences in cognition were observed at baseline imply that preventing infection with helminths in school-age children could be of benefit.
Solution Behaviour of Polyethylene Oxide, Nonionic Gemini Surfactants (2002)

In recent years there has been increasing interest in novel forms of surfactants. Of particular interest are gemini surfactants, which consist of two conventional surfactants joined by a spacer at the head groups, as they exhibit lower critical micelle concentrations than can be achieved by conventional surfactants. In this work, the self-assembly behaviour of several nonionic gemini surfactants with polyethylene oxide head groups (GemnEm, where n (= 20) is the number of carbons per tail and m (= 10, 15, 20 and 30) is the number of ethylene oxides per head group) were investigated. The Critical Micelle Concentrations (CMCs) were measured using a fluorescence probe technique. The CMCs are all ~2 x 10?7 M, with almost no variation with m. The CMCs are several orders of magnitude lower than conventional C12Em nonionic surfactants. The mixing behaviour of the gemini surfactants with conventional surfactants was also studied. They obeyed ideal mixing behaviour with both ionic and nonionic surfactants. Micelle morphologies were studied using Small Angle Neutron Scattering. The gemini surfactants with the larger head groups (i.e. Gem20E20 and Gem20E30) formed spherical micelles. Gem20E15 showed strong scattering at low Q, characteristic of elongated micelles. As the temperature was increased towards the cloud point, the scattering approached the Q-1 dependence predicted for infinite, straight rods. The existence of anisotropic micelles was supported by the viscosity of Gem20E15, which increases by several orders of magnitude on heating towards its cloud point. Phase behaviour was determined using Diffusive Interfacial Transport coupled to near-infrared spectroscopy. Much of the behaviour of these systems is similar to conventional nonionic surfactants. For example, Gem20E10 forms a dilute liquid isotropic phase (W) coexisting with a concentrated lamellar phase (La) at around room temperature and forms a sponge phase at higher temperatures. This is similar to the behaviour of C12E3 and C12E4. The other surfactants studied are all quite soluble in water and form liquid isotropic and hexagonal phases from room temperature. At higher concentrations Gem20E15 formed a cubic and then a lamellar phase while Gem20E20 formed a cubic phase and then an intermediate phase. This is also comparable to the phase behaviour of conventional nonionic surfactants except the intermediate phase, which is often only observed for surfactant systems with long alkyl tails.
A Method for High Precision Enlargement of Pictures taken by Cellular Phone on Personal Computer (2004)

In this paper, we propose a method to enlarge and display images of picture with high precision and scal-ability taken by cellular phone on personal computer without producing jaggy noises. One of the major problems we face in image en-largement is the amplification of the jaggy edges. To deal with this problem, we first detect the edges, and approximate them using three kinds of functions in-cluding straight line, arc and quadratic curve. In ad-dition, the color information of the enlarged image is determined by interpolation using quadratic Fluency DA function, which is subsequently merged with the edge information obtained earlier. This enables the construction of a high precision and scalable image that cannot be produced by conventional image cod-ing method such as JPEG or MPEG. The proposed method is evaluated by applying to images taken by cellular phone equipped with CCD camera to demon-strate its effectiveness.
A wireless-sensor scoring and training system for combative sports (2005)

Although historically among the most popular of sports, today, combative sports are often viewed as an expression of our savage past. Of primary concern are the long term effects of participating in these sports on the health of participants. The scoring of such sports has also been the subject of much debate, with a panel of judges making decisions about very quick events involving large sums of prize money. This paper describes an electronic system for use primarily in the sport of boxing, though it is suitable for martial arts such as karate and taekwondo. The technology is based on a previously described sensor platform and integrates a network of sensors on the athlete’s head, body and hands. Using a Bluetooth network, physical contacts are monitored in near real-time or post event on a remote computer to determine legal hits and hence derivative measures like scoring and final outcomes. It is hoped that this system can be applied to reduce the need for full contact contests as well as provide a more reliable method of determining the outcome of a bout. Other benefits presented here include the ability to analyse an athlete's performance post match or training session, such as assessing the efficacy of training drills and effects of fatigue.
Diversity at the<i>Mla</i>Powdery Mildew Resistance Locus from Cultivated Barley Reveals Sites of Positive Selection (2010)

The Mla locus in barley (Hordeum vulgare) conditions isolate-specific immunity to the powdery mildew fungus (Blumeria graminis f. sp. hordei) and encodes intracellular coiled-coil (CC) domain, nucleotide-binding (NB) site, and leucine-rich repeat (LRR)-containing receptor proteins. Over the last decades, genetic studies in breeding material have identified a large number of functional resistance genes at the Mla locus. To study the structural and functional diversity of this locus at the molecular level, we isolated 23 candidate MLA cDNAs from barley accessions that were previously shown by genetic studies to harbor different Mla resistance specificities. Resistance activity was detected for 13 candidate MLA cDNAs in a transient gene-expression assay. Sequence alignment of the deduced MLA proteins improved secondary structure predictions, revealing four additional, previously overlooked LRR. Analysis of nucleotide diversity of the candidate and validated MLA cDNAs revealed 34 sites of positive selection. Recombination or gene conversion events were frequent in the first half of the gene but positive selection was also found when this region was excluded. The positively selected sites are all, except two, located in the LRR domain and cluster in predicted solvent-exposed residues of the repeats 7 to 15 and adjacent turns on the concave side of the predicted solenoid protein structure. This domain-restricted pattern of positively selected sites, together with the length conservation of individual LRR, suggests direct binding of effectors to MLA receptors.
8-electrode capacitance system for two-component flow identification. Part 1: Tomographic flow imaging (1989)

An 8-electrode capacitance system for tomographic imaging of two-component flows has been designed based upon a 2-dimensional finite element model. Emphasis is made on the development of a linear back-projection image reconstruction algorithm. Some reconstructed images obtained using this algorithm are given. Limitations and possible future improvements of the system are discussed.
Reduced-order modelling of linear time-varying systems (1998)

We present a theory for reduced order modelling of linear time varying systems, together with efficient numerical methods for application to large systems. The technique, called TVP (Time-Varying Pade), is applicable to deterministic as well as noise analysis of many types of communication subsystems, such as mixers and switched capacitor filters, for which existing model reduction techniques cannot be used. TVP is therefore suitable for hierarchical verification of entire communication systems. We present practical applications in which TVP generates macromodels which are more than two orders of magnitude smaller but still replicate the input-output behaviour of the original systems accurately. The size reduction results in a speedup of more than 500.
People location and orientation tracking in multiple views (2009)

This paper presents a multi-view approach to the tracking of people location and orientation. To achieve efficient and accurate likelihood evaluation, a novel likelihood computation method is proposed. Mixtures of Gaussian (MoG) are used to represent the color models of subjects. The scaled unscented transformation is used to project the MoG color models onto the image plane to predict the color distribution for a motion sample. The efficacy of the proposed approach is demonstrated by experiment results obtained using real videos.
The end of politics? Looking beyond the election (2001)

Those hoping for resolution and relief from politics and political strife after the election may be distressed. Washington in 2001 and 2002 may well be the most politically interesting and tumultuous time in many years. Here's a preview…
Robust Monocular Epipolar Flow Estimation (2013)

We consider the problem of computing optical flow in monocular video taken from a moving vehicle. In this setting, the vast majority of image flow is due to the vehicle's ego-motion. We propose to take advantage of this fact and estimate flow along the epipolar lines of the egomotion. Towards this goal, we derive a slanted-plane MRF model which explicitly reasons about the ordering of planes and their physical validity at junctions. Furthermore, we present a bottom-up grouping algorithm which produces over-segmentations that respect flow boundaries. We demonstrate the effectiveness of our approach in the challenging KITTI flow benchmark [11] achieving half the error of the best competing general flow algorithm and one third of the error of the best epipolar flow algorithm.