gebhart/patrepeval huggingface dataset:
Additions of singlet oxygen to alkoxy-substituted butadienes. An unexpectedly large s-cis/s-trans ratio in an (E,Z)-diene or a kinetic anomeric effect? (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions of singlet oxygen to alkoxy-substituted butadienes. An unexpectedly large s-cis/s-trans ratio in an (E,Z)-diene or a kinetic anomeric effect?Edward L. Clennan, Robert P. L'Esperance, and Kathleen K. LewisCite this: J. Org. Chem. 1986, 51, 9, 1440–1446Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/jo00359a012https://doi.org/10.1021/jo00359a012research-articleACS PublicationsRequest reuse permissionsArticle Views134Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A graph rewriting approach for transformational design of digital systems (2002)

Transformational design integrates design and verification. It combines "correctness by construction" and design creativity by the use of pre-proven behaviour preserving transformations as design steps. The formal aspects of this methodology are hidden in the transformations. A constraint is the availability of a design representation with a compositional formal semantics. Graph representations are useful design representations because of their visualisation of design information. In this paper graph rewriting theory, as developed in the last twenty years in mathematics, is shown to be a useful basis for a formal framework for transformational design. The semantic aspects of graphs which are no part of graph rewriting theory are included by the use of attributed graphs. The used attribute algebra, table algebra, is a relation algebra derived from database theory. The combination of graph rewriting, table algebra and transformational design is new.
Patnet : A Phoneme-Level Autoregressive Transformer Network for Speech Synthesis (2021)

Aiming at efficiently predicting acoustic features with high naturalness and robustness, this paper proposes PATNet, a neural acoustic model for speech synthesis using phoneme-level autoregression. PATNet accepts phoneme sequences as input and is built based on Transformer structure. PATNet adopts a duration model instead of attention mechanism for sequence alignment. The decoder of PATNet predicts multi-frame spectra within one phoneme in parallel given the predicted spectra of previous phonemes. Such phoneme-level autoregression enables PATNet to achieve higher inference efficiency than the models with frame-level autoregression, such as Transformer-TTS, and improves the robustness of acoustic feature prediction by utilizing phoneme boundaries explicitly. Experimental results show that the speech synthesized by PATNet obtained lower character error rate (CER) than Tacotron, Transfomer-TTS and FastSpeech when evaluated by a speech recognition engine. Besides, PATNet achieved 10 times faster inference speed than Transformer-TTS and significantly better naturalness than FastSpeech.
Four quadrant FGMOS analog multiplier (2011)

A novel four-quadrant analog multiplier using floating gate MOS (FGMOS) transistors operating in the saturation region is presented. The drain current is proportional to the square of the weighted sum of the input signals. This square law characteristic of the FGMOS transistor is used to implement the quarter square identity by utilizing only six FGMOS transistors. The main features of this remarkably simple multiplier circuit configuration are the large input signal range equal to 100% of the supply voltage, nonlinearity of 0.0081%, bandwidth of 1.4--1.5 Ghz and THD of maximum 2.67% (while the inputs are at their maximum values).
Educational models for producing more management engineers. (1992)

Academic programs that attract and train health systems management professionals need the help of the profession working through our technical societies. We need to seek ways to interest IE and other faculty in these programs. Interactions between health care institutions and academic programs can be an important way for students to discover the wealth of opportunities that exist in health systems management.
P-Mail: Design and implementation of a novel heterogeneous picture mailer (2008)

This paper describes the implementation of mailer that is used to send the mail in the mailer that has encoded format. By using this encoding method the mail will be send very safe, the hackers can't read the mail. The mailer is used to send the encrypted mail directly to the mail box as it is. It can also send the effective html page, images and textual mails. instead of this, the composer will send the mail with the enclosures(not as attachment) like .GIF/ .PNG/ .SWF/ .JPG.
Imaging radar maps underground objects in 3-D (2000)

City streets cover a complex array of underground electric, gas, and communication lines. Effective maintenance, expansion, and new installation of these networks require accurate information regarding the location of the conduits, cables, and other structures that lie beneath the surface. Underground maps, if they exist, are often inaccurate, incomplete, or out of date, and attempts to find underground lines or obstacles using metal locators often prove disappointing. To help companies create accurate maps of subsurface networks, researchers have developed a new ground-penetrating imaging radar (GPIR) system that creates sharp, three-dimensional (3-D) images of underground lines and objects. Schlumberger Corporation, in conjunction with the Electric Power Research Institute (EPRI) and the Gas Research Institute, has developed a GPIR system that detects, locates, and produces 3D maps of underground features. The new underground imaging system holds the potential to reduce utility operating and maintenance costs by avoiding unneeded excavation and by reducing incidences of costly damage such as ruptured gas lines. Field demonstrations in New York City, San Diego, and other utility locations have proven the ability of the new mapping system to create accurate images of objects in crowded urban areas at depths as great as 10 ft (3 m).
The structures of four new taxinine congeners, and a photochemical transannular reaction (1967)

H. C. Chiang, M. C. Woods, Y. Nakadaira and K. Nakanishi, Chem. Commun. (London), 1967, 1201 DOI: 10.1039/C19670001201
Tat Protein of Human Immunodeficiency Virus Type 1 Subtype C Strains Is a Defective Chemokine (2004)

Human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) is correlated with increased monocyte migration to the brain, and the incidence of HAD among otherwise asymptomatic subjects appears to be lower in India than in the United States and Europe (1 to 2% versus 15 to 30%). Because of the genetic differences between HIV-1 strains circulating in these regions, we sought to identify viral determinants associated with this difference. We targeted Tat protein for these studies in view of its association with monocyte chemotactic function. Analyses of Tat sequences representing nine subtypes revealed that at least six amino acid residues are differentially conserved in subtype C Tat (C-Tat). Of these, cysteine (at position 31) was highly (>99%) conserved in non-subtype C viruses and more than 90% of subtype C viruses encoded a serine. We hypothesized a compromised chemotactic function of C-Tat due to the disruption of CC motif and tested it with the wild type C-Tat (CS) and its two isogenic variants (CC and SC) derived by site-directed mutagenesis. We found that the CS natural variant was defective for monocyte chemotactic activity without a loss in the transactivation property. While the CC mutant is functionally competent for both the functions, in contrast, the SC mutant was defective in both. Therefore, the loss of the C-Tat chemotactic property may underlie the reduced incidence of HAD; although not presenting conclusive evidence, this study provides the first evidence for a potential epidemiologic phenomenon associated with biological differences in the subtype C viruses.
α-AMANITIN RESISTANCE IN THREE WILD STRAINS OF <i>DROSOPHILA MELANOGASTER</i> (1982)

Three wild strains of D. melanogaster have been identified which are resistant to normally lethal levels of the fungal toxin, alpha-amanitin. Dietary LD50S for Oregon-R, the reference strain, and Ama-KTT, Ama-MI and Ama-KLM, the resistant strains, are 1.2, 35, 30 and 10 micrograms alpha-amanitin/vial, respectively. Resistance in all three strains is a digenic trait, being determined by two independently acting dominant genes, Ama-1, Ama-2, either of which is sufficient to confer resistance and which are located at approximately 18.8 and 100.7, respectively, on chromosome 3. Resistance to alpha-amanitin in all three strains is apparently not mediated by modification of RNA polymerase form II nor by failure of toxin transport or by toxin inactivation.
Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with Schistosomes (2009)

Abnormal fibrosis occurs during chronic hepatic inflammations and is the principal cause of death in hepatitis C virus and schistosome infections. Hepatic fibrosis (HF) may develop either slowly or rapidly in schistosome-infected subjects. This depends, in part, on a major genetic control exerted by genes of chromosome 6q23. A gene (connective tissue growth factor [CTGF]) is located in that region that encodes a strongly fibrogenic molecule. We show that the single nucleotide polymorphism (SNP) rs9402373 that lies close to CTGF is associated with severe HF (P = 2 x 10(-6); odds ratio [OR] = 2.01; confidence interval of OR [CI] = 1.51-2.7) in two Chinese samples, in Sudanese, and in Brazilians infected with either Schistosoma japonicum or S. mansoni. Furthermore, SNP rs12526196, also located close to CTGF, is independently associated with severe fibrosis (P = 6 x 10(-4); OR = 1.94; CI = 1.32-2.82) in the Chinese and Sudanese subjects. Both variants affect nuclear factor binding and may alter gene transcription or transcript stability. The identified variants may be valuable markers for the prediction of disease progression, and identify a critical step in the development of HF that could be a target for chemotherapy.
Worldwide Genetic Relationships among <i>Francisella tularensis</i> Isolates Determined by Multiple-Locus Variable-Number Tandem Repeat Analysis (2004)

The intracellular bacterium Francisella tularensis is the causative agent of tularemia and poses a serious threat as an agent of bioterrorism. We have developed a highly effective molecular subtyping system from 25 variable-number tandem repeat (VNTR) loci. In our study, multiple-locus VNTR analysis (MLVA) was used to analyze genetic relationships and potential population structure within a global collection of 192 F. tularensis isolates, including representatives from each of the four subspecies. The VNTR loci displayed between 2 and 31 alleles with Nei's diversity values between 0.05 and 0.95. Neighbor-joining cluster analysis of VNTR data revealed 120 genotypes among the 192 F. tularensis isolates, including accurate subspecies identification. F. tularensis subsp. tularensis (type A) isolates showed great diversity at VNTR loci, while F. tularensis subsp. holarctica (type B) isolates showed much lower levels despite a much broader geographical prevalence. The resolution of two distinct clades within F. tularensis subsp. tularensis (designated A.I and A.II) revealed a previously unrecognized genetic division within this highly virulent subspecies. F. tularensis subsp. holarctica appears to have recently spread globally across continents from a single origin, while F. tularensis subsp. tularensis has a long and complex evolutionary history almost exclusively in North America. The sole non-North American type A isolates (Slovakian) were closely related to the SCHU S4 strain. Significant linkage disequilibrium was detected among VNTR loci of F. tularensis consistent with a clonal population structure. Overall, this work greatly augments the study of tularemia ecology and epidemiology, while providing a framework for future forensic analysis of F. tularensis isolates.
Clinicopathological and prognostic characteristics of CD33‐positive multiple myeloma (2006)

There have been few reports about the CD33 expression on multiple myeloma (MM) cells so far, showing that only a few patients expressed CD33 homogenously on their MM cells. However, in these reports, neither detailed clinical information nor its prognostic significance was described. Therefore, we analyzed the CD33 expression on MM cells from 63 newly diagnosed patients by flow cytometry and the correlation with other clinical parameters to determine the clinicopathological significance of this molecule. Fourteen (22%) patients were positive for CD33. Of the 14 patients with CD33+ MM, >80% of MM cells were positive in six (9.5%). The CD33+ patients had higher beta 2 microglobulin and lactate dehydrogenase levels and higher incidence of anemia and thrombocytopenia than did CD33- patients. The estimated 3-yr overall survival in CD33+ patients was significantly lower than in the CD33- ones (31% and 50%, respectively, P = 0.042). Especially, mortality within a year from diagnosis in the CD33+patients was higher than that in CD33- patients (43% and 10%, respectively, P = 0.005). Serial evaluation of CD33 expression showed that the amount of CD33 significantly increased after a variety of treatment including melphalan and steroid in individual patients. These results suggest that the CD33 expression might be associated with drug resistance to these conventional agents, and CD33 might be a useful target for the development of new therapeutic agents in MM.
General Joffre at Close Range (1916)

Essay| April 01 1916 General Joffre at Close Range H. G. Cardozo H. G. Cardozo Special Correspondent of The London Daily Mail Search for other works by this author on: This Site PubMed Google Scholar Current History (1916) 4 (1): 132–133. https://doi.org/10.1525/curh.1916.4.1.132 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation H. G. Cardozo; General Joffre at Close Range. Current History 1 April 1916; 4 (1): 132–133. doi: https://doi.org/10.1525/curh.1916.4.1.132 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCurrent History Search This content is only available via PDF. © 1916 by The Regents of the University of California1916 Article PDF first page preview Close Modal You do not currently have access to this content.
The new genetics: The new genetics in clinical practice (1998)

Is it the cognitive-behavioural component of the therapy that works, or is non-specific group support more important?
Endoluminal Grafting for Aneurysmal and Occlusive Disease in the Superficial Femoral Artery: Early Experience (1995)

Purpose: To examine whether endoluminal grafts (ELGs) of radially expandable polytetrafluoroethylene (PTFE) can successfully form durable internal conduits to revascularize lengthy occlusive disease and exclude aneurysms in the femoropopliteal (FP) arteries. Methods: Under protocol, implantation of an unpredilated PTFE tube ELG anchored with Palmaz stents using a low-profile percutaneous delivery system was attempted in 50 symptomatic patients for a variety of pathologies: (1) restenosis; (2) complex lesions unlikely to be treated successfully with other endoluminal therapies; (3) acute angioplasty failure; and (4) aneurysms. There were 37 occlusions, 14 stenoses, and 2 long, combined stenoticaneurysmal lesions in 47 native arteries, 5 FP grafts, and 1 femorotibial (FT) vein graft. Thirty-two percent of the patients had ≤ 1 vessel runoff. The average lesion length was 20.4 ± 11.4 cm (range 1.5 to 40), and the mean preoperative ankle-brachial index (ABI) at rest was 0.53 ± 0.14. Results: In a 20-month period through April 1995, 50 patients (34 males, 16 females; mean age 69.5 years, range 45 to 87) underwent 54 procedures in 53 limbs; 55 ELGs were successfully deployed in 51 limbs; 2 patients were converted to FP bypass owing to technical problems (96% procedural success). There were 18 inhospital complications: 1 distal wire dissection repaired with an additional ELG; 2 hematomas requiring surgical repair; 1 graft collapse; 1 pseudoaneurysm at the site of a mid-ELG leak; 7 minor access sequelae; and 6 acute ELG thromboses, 4 treated with lytic therapy and balloon dilation, 1 with open thrombectomy, and 1 with bypass grafting. The mean postoperative ABI was 1.01 ± 0.10. During the 30-day postprocedure period, 2 ELGs rethrombosed and 2 other limbs (3 ELGs) occluded; 1 thrombosis and 1 rethrombosis were lysed successfully, but the other 2 patients had an FP bypass. Over the mean 8.3 ± 5.5 month follow-up, 6 additional ELGs occluded and 1 reoccluded; 4 were successfully treated by endovascular techniques for a primary patency of 72% and secondary patency of 84% by life-table analysis. Conclusions: Endovascular grafting is a conceptually attractive technique that has the potential to expand the current boundaries of interventional treatment. This preliminary experience attests to the feasibility and safety of ELG deployment in the superficial femoral arteries. Whether such a device can match the durability of classical revascularization techniques remains to be determined in clinical trials when device configurations and deployment techniques have been standardized.
CHISEL flash EEPROM. II. Reliability (2002)

For pt. I see ibid., vol. 49, no. 7, pp. 1302-1307 (2002). In this work, we demonstrate the feasibility of using channel initiated secondary electron (CHISEL) programming in high density flash memories containing fully scaled memory cells. We discuss endurance and reliability of single cells and large arrays. We demonstrate from single cell measurements that after program/erase cycling, CHISEL operation shows lower threshold voltage window closure, lower program time degradation, reduced hole trapping, and device degradation, with a marginal increase in erase time compared to conventional channel hot electron (CHE) operation. The reasons for improved reliability of CHISEL operation are explained using device simulation. CHISEL programming also shows reduced charge gain drain disturb with only slightly higher charge loss drain disturb compared to CHE operation. Measurements on large 32-Mb array under CHISEL operation show tight threshold voltage distribution and more than ten years of data retention even after 100-k cycling. Results are presented showing excellent reliability of CHISEL programming operation for deeply scaled high density flash EEPROMs.
Trusted host-based card emulation (2015)

Near Field Communication (NFC) promises to boost mobile transactions and payments. Indeed, NFC-enabled devices can emulate smartcards, so allowing payments, loyalty programs, card access, transit passes and other custom services, through a mobile phone. Although many modern mobile devices mount a NFC transceiver, card emulation is still a rare feature. The main reason is that the two available card emulation frameworks, namely Card Emulation and Host-based Card Emulation, have known limitations in terms of usability and security (respectively). This paper proposes a novel approach to card emulation called Trusted Host-based Card Emulation (THCE). THCE relies on the Trusted Execution Environment, currently deployed on most of the CPUs for mobile devices, and implements a secure and usable card emulation framework. Through comparisons, we show that THCE overcomes the limitations of the existing solutions. Moreover, we formally verify that the initialization protocol, used to deploy access credentials on a THCE-enabled device, is not vulnerable to known exploits.
Mechanics of Elastic Performance of Textile Materials (1967)

A theoretical analysis of the load-elongation behavior of idealized plain-weave fabrics subjected to biaxial stresses is presented. Fabric strains resulting from both crimp interchange and yarn extension are considered. The analytical expressions de rived have been solved with the aid of a digital computer for both linearly elastic and elasto-plastic materials. Time effects, although not explicitly included, are discussed. Generalized plots of the results are presented for the two extremes of initial fabric structure: (1) equal crimp distribution in both sets of yarns and (2) one set of yarns noncrimped (straight). The predicted and measured response of model fabrics are compared.
Response Characteristics of Thermoresponsive Polymers Using Nanomechanical Cantilever Sensors (2009)

Abstract We investigated coatings of thermally responsive thin polymer films prepared on nanomechanical cantilever sensor (NCS): (i) a PNIPAM brush, and (ii) an interlinked ppDEA polymer. Upon heating from 22 to 50 °C in water, a minimum in the differential deflection between 31.9 ± 1.7 °C (PNIPAM) and 47.7 ± 1.9 °C (ppDEA) was measured. The minimum in differential deflection can be associated with the lower critical solution temperature (LCST) of the films. Below the LCST the NCS deflection corresponds to a bending toward the thermally responsive polymer film side, associated to dehydration. At higher temperature, the deflection was reversed, i.e., away from the polymer coating. This response is mainly attributed to a bimaterial effect between the collapsed polymer and the NCS material. The LCST of the PNIPAM brush layer and the ppDEA film were close to that reported for the bulk polymers. magnified image
Noninvasive Evaluation of Active Lower Gastrointestinal Bleeding: Comparison Between Contrast-Enhanced MDCT and <sup>99m</sup>Tc-Labeled RBC Scintigraphy (2008)

Contrast-enhanced MDCT and (99m)Tc-labeled RBC scanning show significant disagreement for evaluation of active lower gastrointestinal bleeding. Contrast-enhanced MDCT appears effective for detection and localization in cases of active lower gastrointestinal bleeding in which hemorrhage is active at the time of CT.
Chikungunya Virus Vaccines: Viral Vector–Based Approaches: Table 1. (2016)

In 2013, a major chikungunya virus (CHIKV) epidemic reached the Americas. In the past 2 years, >1.7 million people have been infected. In light of the current epidemic, with millions of people in North and South America at risk, efforts to rapidly develop effective vaccines have increased. Here, we focus on CHIKV vaccines that use viral-vector technologies. This group of vaccine candidates shares an ability to potently induce humoral and cellular immune responses by use of highly attenuated and safe vaccine backbones. So far, well-described vectors such as modified vaccinia virus Ankara, complex adenovirus, vesicular stomatitis virus, alphavirus-based chimeras, and measles vaccine Schwarz strain (MV/Schw) have been described as potential vaccines. We summarize here the recent data on these experimental vaccines, with a focus on the preclinical and clinical activities on the MV/Schw-based candidate, which is the first CHIKV-vectored vaccine that has completed a clinical trial.