gebhart/patrepeval huggingface dataset:
Single crystal FBAR with LiNbO3 and LiTaO3 piezoelectric substance layers (2007)

The film bulk acoustic resonator (hereinafter referred to as FBAR) has been proposed for use as a high performance filter. FBAR consists of an acoustic resonator through use of a thin film deposition process. On the other hand, single crystals have been widely utilized as material for resonators due to their material uniformity, low material defect rates, and high material stability. The use of a single crystal to achieve a high frequency resonator will further expand FBAR's application ranges. In this paper, we present single crystal FBAR that is characterized by low loss and high bandwidth. Additionally, this device has the following features: the capability to fabricate a single crystal acoustic resonator through the use of single crystal micro processing technology, such as a single crystal wafer junction, polishing, and etching; and the capability of a wide range of desired filter bandwidths, each able to secure an ample amount of high performance characteristics by varying the single crystal's type and direction. LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (LN) and LiTaO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (LT), each with the large electromechanical coupling factor kt <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , are used for the single crystal. 3-inch full-wafer processing is performed, thereby yielding superior uniformity resonators.
<i>N,N′</i>‐Cyclization of carbodiimides with 2‐(bromomethyl)acrylic acid. A direct entry to the system 5‐methylene‐6<i>H</i>‐pyrimidine‐2,4‐dione, a new class of thymine analogues (1996)

Abstract Carbodiimides react under very mild conditions with 2‐(bromomethyl)acrylic acid at both N atoms to give 1,3‐disubstituted‐5‐methylene‐6 H ‐pyrimidine 2,4‐dione derivatives in moderate to good yields. These products behaved as good Michael acceptors towards a variety of nucleophiles such as bromine, hydrochloric acid, hydrides, etc . A plausible mechanism is proposed based on theoretical approaches and experimental results.
The Use of Residual-Gas-Analysis Techniques for Vacuum Process Control and Troubleshooting (1971)

First Page
The constitution of <i>Tamarindus</i>‐amyloid (1961)

Abstract The preparation of Tamarindus ‐amyloid from seeds of Tamarindus indica L. is described in detail. The product was homogeneous under conditions of free boundary electrophoresis and of sedimentation in the ultracentrifuge. A tentative value for a molecular weight of 115,000 was found. Partial hydrolysis of the polysaccharide with Myrotheciwn ‐cellulase liberated a hepta‐, an octa‐ and a nona‐saccharide, while a fungal enzyme “Luizym” yielded 6‐O‐α‐D‐xylopyranosyl‐D‐glucopyranose. Partial hydrolysis with dilute mineral acid gave the disaccharide 2‐O‐β‐D‐galactopyranosyl‐D‐xylopyranose. Experimental evidence is presented for the following structural features: A main chain of β 1,4‐linked glucose residues. A xylose residue attached by an α 1,6‐linkage to three glucose residues out of every four. The three substituted glucose residues and the unsubstituted one alternate regularly. The galactose residues are attached to the xylose residues by β 1,2‐linkages. On the basis of this evidence a structure for Tamarindus ‐amyloid is proposed.
Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies (2010)

Cancer Research UK.
Inductive and capacitive VAR compensation with forced commutated high-frequency cycloconvertors (1983)

Forced commutated VAR compensator principles are well known. The letter, however, discusses how internal current harmonics may modify the mains frequency reactive energy production or consumption pattern. They permit VAR systems to behave both inductively and capacitively, without requiring any additional shunt elements.
Health Assessment for Tools in Milling Machine Using the Mahalanobis–Taguchi System Based on WPT-AR (2013)

A real-time tool health assessment has a profound significance on reliable machining operations. This paper proposes a health assessment method for tools in milling machine sing the Mahalanobis–Taguchi system (MTS) based on Wavelet Packet Transformation and Autoregression (WPT-AR). In this method, the nonlinear and non-stationary vibration signal from milling process is first decomposed by wavelet packet transforms. Second, an AR model is constructed for each coefficient of the reconstructed signal, and the parameters and the variance of the remnant of each AR model are employed to form the initial feature matrix. Singular values of this feature matrix are obtained by Singular Value Decomposition, at which point MTS is employed. In this study, MTS provides: (1) a computational scheme based on the Mahalanobis distance (MD) for obtaining the health index of a tool; and (2) Taguchi methods to extract the key features and reduce the redundant ones. Finally, the performance and effectiveness of the proposed method was validated by vibration signals acquired from milling machining process.
Genes Affecting Sensitivity to Serotonin in <i>Caenorhabditis elegans</i> (1996)

Regulating the response of a postsynaptic cell to neurotransmitter is an important mechanism for controlling synaptic strength, a process critical to learning. We have begun to define and characterize genes that may control sensitivity to the neurotransmitter serotonin in the nematode Caenorhabditis elegans by identifying serotonin-hypersensitive mutants. We reported previously that mutations in the gene unc-2, which encodes a putative calcium channel subunit, result in hypersensitivity to serotonin. Here we report that mutants defective in the unc-36 gene, which encodes a homologue of a calcium channel auxiliary subunit, are also serotonin-hypersensitive. Moreover, the unc-36 gene appears to be required in the same cells as unc-2 for control of the same behaviors. Mutations in several other genes, including unc-8, unc-10, unc-20, unc-35, unc-75, unc-77, and snt-1 also result in hypersensitivity to serotonin. Several of these mutations have previously been shown to confer resistance to acetylcholinesterase inhibitors, suggesting that they may affect acetylcholine release. Moreover, we found that mutations that decrease acetylcholine synthesis cause defective egg-laying and serotonin hypersensitivity. Thus, acetylcholine appears to negatively regulate the response to serotonin and may participate in the process of serotonin desensitization.
Alzheimer's Disease and Exercise: A Literature Review (2017)

Alzheimer's disease (AD) is a progressive neurodegenerative disease that impairs memory and cognitive judgment. It is the leading cause of dementia in late adult life and is associated with a significant social burden and increased morbidity and mortality in the elderly. Because of mixed effectiveness of medications, exercise has been considered as a treatment for pre-clinical AD, late stage AD, and as a prevention strategy. Exercise appears to improve brain blood flow, increase hippocampal volume, and improve neurogenesis. Prospective studies indicate that physical inactivity is one of the most common preventable risk factors for developing AD and that higher physical activity levels are associated with a reduced risk of development of disease. Exercise as a treatment for AD shows improvement in cognitive function, decreased neuropsychiatric symptoms, and a slower decline in activities of daily living (ADL). Exercise has been shown to have fewer side effects and better adherence compared to medications.
Dielectric characterization of bacterial cells using dielectrophoresis (2007)

Measurements of dielectrophoretic collection spectra of Escherichia coli and Staphylococcus aureus suspensions are used for obtaining dielectric characteristics of both types of bacteria. The experiments are interpreted using a numerical method that models the cells as compartmented spherical or rod-like particles. We show the usefulness of this simple method to extract significant information about the electrical properties of Gram-negative and -positive bacteria.
Minireview on Glutamine Synthetase Deficiency, an Ultra-Rare Inborn Error of Amino Acid Biosynthesis (2016)

Glutamine synthetase (GS) is a cytosolic enzyme that produces glutamine, the most abundant free amino acid in the human body. Glutamine is a major substrate for various metabolic pathways, and is thus an important factor for the functioning of many organs; therefore, deficiency of glutamine due to a defect in GS is incompatible with normal life. Mutations in the human <i>GLUL</i> gene (encoding for GS) can cause an ultra-rare recessive inborn error of metabolism-congenital glutamine synthetase deficiency. This disease was reported until now in only three unrelated patients, all of whom suffered from neonatal onset severe epileptic encephalopathy. The hallmark of GS deficiency in these patients was decreased levels of glutamine in body fluids, associated with chronic hyperammonemia. This review aims at recapitulating the clinical history of the three known patients with congenital GS deficiency and summarizes the findings from studies done along with the work-up of these patients. It is the aim of this paper to convince the reader that (i) this disorder is possibly underdiagnosed, since decreased concentrations of metabolites do not receive the attention they deserve; and (ii) early detection of GS deficiency may help to improve the outcome of patients who could be treated early with metabolites that are lacking in this condition.
A 2.5-V, 0.35 /spl mu/m CMOS transconductance-capacitor filter with enhanced linearity (2002)

A CMOS transconductance-capacitor (G/sub m/-C) filter with enhanced linearity for low-voltage applications is presented. The proposed design is based on a transconductance amplifier with enhanced linearity. For the elimination of the amplifier harmonic level the compensation principle is used. The transconductor consists of two amplifiers connected in parallel. The input transistors of the first transconductor are working in the saturation region, while the input transistors of the other one are in the triode region. The device was realized as a balanced fifth-order 1MHz low-pass Bessel filter in 0.35/spl mu/m CMOS technology. The filter operates with a low supply voltage of +2.5 Volt. A comparison shows that the discussed filter provides a higher linearity (from 3 to 8 dB) than known circuits with the exception of the filter based on a degenerated transconductor. But it is noted that there are some difficulties to use the last approach for low-voltage application.
[Transcription factors analysis of subchondral bone in early experimental osteoarthritis based on gene expression profiles]. (2018)

The newly identified TFs maybe play important roles in pathogenesis of early experimental osteoarthritis, and our study provides new diagnostic markers or therapeutic targets for OA.
Modes of regulation of ubiquitin-mediated protein degradation (2000)

The ubiquitin-proteasome pathway is responsible for the major portion of specific cellular protein degradation. Ubiquitin-mediated degradation is involved in physiological regulation of many cellular processes, including cell cycle progression, differentiation, and signal transduction. Here, we review the basic mechanisms of the ubiquitin system and the various ways in which ubiquitin-mediated degradation can be modulated by physiological signals.
One-step synthesis and densification of Ti-Al-C-based cermets by ETEPC (2009)

The Electro-Thermal Explosion under Pressure with Confinement (ETEPC) mode of SHS has been studied for producing possibly low-porosity Ti2AlC and Ti3AlC2 from elemental powders in a very short processing time. The effect of maintaining the electric current after the ignition of exothermic reaction has also been studied. A better achievement of the desired reaction, with a total yield of MAX phases up to 73%, was obtained with maintaining the electric current for 4 s after ignition of the exothermic reaction in the Ti: Al: C = 2:1:1 composition. XRD studies revealed also composition gradients.
Factors Contributing to Inshopping Behavior in Rural Trade Areas: Implications for Local Retailers (1997)

Ten male oarsmen performed a 6-min bout of "all-out" exercise on a rowing ergometer in the laboratory. Intraarterial blood pressure was recorded from a catheter inserted percutaneously into the radial artery. Mean arterial pressure increased only modestly from 110 +/- 13 to 122 +/- 24 mm Hg (P < 0.05). Large fluctuations in pressure were superimposed on the normal blood pressure waveform during rowing. These rhythmic pressure fluctuations exhibited a one-to-one coupling with stroke rate and were 2-3 times the magnitude of the normal pulse pressure. Thus, the effective pulse pressure during the 1st minute of rowing (112 +/- 11 mm Hg) was markedly higher (P < 0.01) than the pulse pressure at rest (45 +/- 5 mm Hg) and remained so throughout the exercise bout. In five additional subjects in which central venous pressure (CVP) was measured, large stroke-related fluctuations in pressure were also seen in the CVP waveform. Similar fluctuations in blood pressure were observed during repetitive Valsalva maneuvers. These results suggest that the blood pressure response to rowing is principally influenced by a Valsalva-like maneuver performed at the catch of each stroke. The observed arterial pressure fluctuations may explain the degree of myocardial hypertrophy that occurs in the hearts of rowers.
Transfer of Rhodococcus aichiensis Tsukamura 1982 and Nocardia amarae Lechevalier and Lechevalier 1974 to the Genus Gordona as Gordona aichiensis comb. nov. and Gordona amarae comb. nov. (1994)

We investigated the taxonomic status of Rhodococcus aichiensis DSM 43978T (T = type strain) and Nocardia amarae DSM 43392T by using both chemotaxonomic and genetic methods. The occurrence of MK-9(H2) as the predominant menaquinone, the presence of relatively long-chain mycolic acids (48 to 62 carbon atoms), and the phylogenetic position as determined by a 16S ribosomal DNA sequence analysis provide strong evidence that both R. aichiensis and N. amarae should be transferred to the genus Gordona as Gordona aichiensis and Gordona amarae, respectively.
Aerodynamic shape design of wings using an inverse problem approach (2002)

Describes a computational method for aerodynamic shape design which is one of the major applications of high-performance computing. The design starts from a base-line shape and makes geometrical corrections iteratively until the corrected shape realizes a prescribed pressure distribution. The correction value is obtained by flow simulation and inverse problem solving. In this research, an inverse problem solver has been newly developed for the aerodynamic shape design of multiple wing systems. The solver takes the mutual effect among the wings into consideration and simultaneously provides the section shape of each wing. For flow simulation, Navier-Stokes equations are solved on a vector-parallel machine. Design results show that the method using the inverse problem solver and the high-performance simulation is promising for performing complicated aircraft design within a realistic time period.
Phase-Tilt Array Antenna Design for Dense Distributed Radar Networks for Weather Sensing (2008)

This paper describes the design of a dual-polarized microstrip series-fed linear array as part of the phase-tilt active planar array antenna being designed for weather sensing for the CASA Engineering Research Center. The dual-polarized planar array antenna is composed of 64 linear array columns, each one formed by 32 aperture coupled patch antenna elements in cascade and excited by a 2 W solid state transmit and receive (TR) module. A straightforward synthesis method is used in order to achieve the desired amplitude and phase excitation of each linear array. Radiation patterns computed using method of moments (MoM) and measured in a compact range system are presented in order to validate the synthesis method proposed.
DNA sequencing in a monolithic microchannel device (2000)

We present 50 cm long microchannels in a monolithic device for high resolution, long read-length DNA sequencing. These devices were fabricated and bonded in borofloat glass using unconventional photolithography techniques with 48-188 independent, straight microchannels. The microchannel DNA separation was tested with POP-6 polymer and a DNA sequencing ladder separated at room temperature and 200 V/cm. Single-base resolution greater than 600 bases was achieved and the sequence base called to 640 bases with 98% accuracy. Under the same experimental conditions, the performance of the microchip was identical to a fused-silica capillary with similar cross-sectional area.
G. M. HOPKINS'S “SPRING AND FALL”: AN UNRECORDED PRINTING (1972)

G. M. HOPKINS'S “SPRING AND FALL”: AN UNRECORDED PRINTING Get access ALFRED THOMAS ALFRED THOMAS Enfield, Middlesex Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 19, Issue 2, February 1972, Pages 48-a–48, https://doi.org/10.1093/nq/19-2-48a Published: 01 February 1972
Inflammation and the Regulation of Glutathione Level in Lung Epithelial Cells (1999)

Inflammation is a highly complex biochemical protective response to cellular injury. If this process is continuously unchecked, it leads to chronic inflammation, a hallmark of various inflammatory lung diseases. Reactive oxygen intermediates generated by immune cells recruited to the sites of inflammation are a major cause of cell damage. Glutathione (GSH), is a vital intra- and extracellular protective antioxidant in the lungs. The rate-limiting enzyme in GSH synthesis is gamma-glutamylcysteine synthetase (gamma-GCS). Both GSH and gamma-GCS expression are modulated by oxidants, phenolic antioxidants, inflammatory, and anti-inflammatory agents in lung cells. GSH plays a key role in regulating oxidant-induced lung epithelial cell function and also in the control of pro-inflammatory processes. Alterations in the alveolar and lung GSH metabolism are widely recognized as a central feature of many inflammatory lung diseases. Oxidative processes have a fundamental role in lung inflammation through redox-sensitive transcription factors such as NF-kappaB and AP-1, which regulated the genes for pro-inflammatory mediators and protective antioxidant genes such as gamma-GCS. The critical balance between the induction of pro-inflammatory mediators and antioxidant genes in response to oxidative stress at the site of inflammation is not known. Knowledge of the mechanisms of GSH regulation in lung inflammation could lead to the development of novel therapies based on the pharmacological manipulation of the production of this important antioxidant in lung inflammation and injury. This review describes the potential role of GSH for lung oxidant stress, inflammation and injury.
Zhejiang (2014)

Abstract This chapter discusses the economic development of Zhejiang province which, located in the southern part of the Yangtze Delta on the southeast coast of China, is one of the most densely populated provinces in China. From 1978 to 2011, GDP there rose from Renminbi (RMB) 12.3 billion ($1.9 billion) to RMB 3,200 billion ($495 billion). By 2011, the level of urbanization of Zhejiang province had reached 60 per cent and the value added of the primary, secondary, tertiary industries accounted for 4.9 per cent, 51.3 per cent, and 43.8 per cent of the regional GDP, respectively. This data show that the rapid emergence of a private sector combined with market-oriented economic reforms has propelled Zhejiang province into the middle or later stage of industrialization.
Bayesian fusion of physiological measurements using a signal quality extension (2018)

Our Bayesian learning model provides an extension over existing work to incorporate signal quality as a confidence measure to improve the reliability of fusing labels from biomedical datasets.
Quantum Well and Quantum Dot Light Emitters Confined in Oxide-Semiconductor Microcavities (1998)

Smaller sized, low power silicon semiconductor devices can be used to create more powerful computer chips, but also result in greater difficulty in signal transmission. Recent developments in fabricating III–V microcavity lasers and III–V quantum dots offer possible solutions.
A Branch-and-Bound algorithm using multiple GPU-based LP solvers (2013)

The Branch-and-Bound (B&B) method is a well-known optimization algorithm for solving integer linear programming (ILP) models in the field of operations research. It is part of software often employed by businesses for finding solutions to problems such as airline scheduling problems. It operates according to a divide-and-conquer principle by building a tree-like structure with nodes that represent linear programming (LP) problems. A LP solver commonly used to process the nodes is the simplex method. Nowadays its sequential implementation can be found in almost all commercial ILP solvers. In this paper, we present a hybrid CPU-GPU implementation of the B&B algorithm. The B&B tree is managed by the CPU, while the revised simplex method is mainly a GPU implementation, relying on the CUDA technology of NVIDIA. The CPU manages concurrently multiple instances of the LP solver. The principal difference with a sequential implementation of the B&B algorithm pertains to the LP solver, provided that the B&B tree is managed with the same strategy. We thus compared our GPU-based implementation of the revised simplex to a well-known open-source sequential solver, named CLP, of the COIN-OR project. For given problem densities, we measured a size threshhold beyond which our GPU implementation outperformed its sequential counterpart.
Empowering Self-Driving Networks (2018)

As emerging network technologies and softwareization render networks more flexible, the question arises of how to exploit these flexibilities for optimization. Given the complexity of the involved network protocols and the context in which networks are operating, such optimizations are increasingly difficult to perform. An interesting vision in this regard are "self-driving" networks: networks which measure, analyze and control themselves in an automated manner, reacting to changes in the environment (e.g., demand), while exploiting existing flexibilities to optimize themselves.
Inhibition of Activator Protein 1 Activity and Neoplastic Transformation by Aspirin (1997)

Aspirin, along with its analgesic-antipyretic uses, is now also being considered for prevention of cardiovascular disease, cancer, and treatment of human immunodeficiency virus infection. Although many of aspirin's pharmacological actions are related to its ability to inhibit prostaglandin biosynthesis, some of its beneficial therapeutic effects are not completely understood. Transcription factor activator protein 1 (AP-1) is critical for the induction of neoplastic transformation and induction of multiple genes involved in inflammation and infection. We have used the JB6 mouse epidermal cell lines, a system that has been used extensively as an in vitro model for the study of tumor promotion and anti-tumor promotion, to study the anti-carcinogenesis effect of aspirin at the molecular level. Aspirin and aspirin-like salicylates inhibited the activation of AP-1 in the same dose range as seen for the inhibition of tumor promoter-induced transformation. The inhibition of AP-1 and tumor promoter-induced transformation in JB6 cells occurs through a prostaglandin independent- and an Erk1- or Erk2-independent pathway. The mechanism of AP-1 and transformation inhibition in this cell culture model may involve the elevation of H+ concentration. The inhibition effects on the activation of AP-1 activity by aspirin and aspirin-like salicylates may further explain the anti-carcinogenesis mechanism of action of these drugs.