gebhart/patrepeval huggingface dataset:
Exploiting Region Of Interest For Improved Video Coding (2009)

Today massive video data transfers are successfully done over the Internet.But, achieving a good quality real time video Transfer is still a challenge.Video requires large bandwidth for error-free transmission over the network.Since bandwidth is an expensive resource, ensuring sufficient bandwidth for error free transmission of video is difficult.Hence, low bit rate transmission is preferred.But low bit rate transmission implies lower quality video.This is where Region of Interest Video Coding comes into play.It uses the fact that there are certain areas in the video which are of higher perceptual importance than other areas and assigns a higher quality to those areas.Hence a better perceptual video quality is achieved under the same bandwidth conditions.Region of Interest Coding can be broken into 2 parts: Region of Interest Tracking and Video Preprocessing.Region of Interest Tracking involves tracking the region of interest in all the frames of the video based on some criteria specified by the user.Video Preprocessing is the preprocessing performed, to ensure higher quality to the region of interest over the background.This thesis presents a methodology for both Region of Interest Tracking and Video preprocessing.In Region of Interest Tracking, a covariance tracking method is studied and is applied in the 2 different cases of rigid and non rigid body motion of the Region of Interest (ROI).In Video preprocessing, a VITA
A Perturbed Ubiquitin Landscape Distinguishes Between Ubiquitin in Trafficking and in Proteolysis (2011)

Any of seven lysine residues on ubiquitin can serve as the base for chain-extension, resulting in a sizeable spectrum of ubiquitin modifications differing in chain length or linkage type. By optimizing a procedure for rapid lysis, we charted the profile of conjugated cellular ubiquitin directly from whole cell extract. Roughly half of conjugated ubiquitin (even at high molecular weights) was nonextended, consisting of monoubiquitin modifications and chain terminators (endcaps). Of extended ubiquitin, the primary linkages were via Lys48 and Lys63. All other linkages were detected, contributing a relatively small portion that increased at lower molecular weights. In vivo expression of lysineless ubiquitin (K0 Ub) perturbed the ubiquitin landscape leading to elevated levels of conjugated ubiquitin, with a higher mono-to-poly ratio. Affinity purification of these trapped conjugates identified a comprehensive list of close to 900 proteins including novel targets. Many of the proteins enriched by K0 ubiquitination were membrane-associated, or involved in cellular trafficking. Prime among them are components of the ESCRT machinery and adaptors of the Rsp5 E3 ubiquitin ligase. Ubiquitin chains associated with these substrates were enriched for Lys63 linkages over Lys48, indicating that K0 Ub is unevenly distributed throughout the ubiquitinome. Biological assays validated the interference of K0 Ub with protein trafficking and MVB sorting, minimally affecting Lys48-dependent turnover of proteasome substrates. We conclude that despite the shared use of the ubiquitin molecule, the two branches of the ubiquitin machinery--the ubiquitin-proteasome system and the ubiquitin trafficking system--were unevenly perturbed by expression of K0 ubiquitin.
Practical method to facilitate estimation of Streptococcus mutans levels in saliva (1979)

A method was developed to facilitate the estimation of Streptococcus mutans levels in saliva. Saliva-contaminated wodden spatulas were pressed directly against an elevated agar plate containing a selective medium. The results were compared with the number of S. mutans per 1 ml of paraffin-stimulated saliva. It was shown that the spatula method gave a good estimation of the level of S. mutans infection. The incubation was also made in expired air instead of 95% N2-5% CO2. The outgrowth was in good agreement with that after conventional incubation. The method is useful in epidemiological studies or in selecting persons at a high caries risk, and when ordinary saliva sampling cannot be done, for example in small children. Compared with conventional saliva sampling, this method requires less time and material at sampling as well as at the laboratory.
The high-performance liquid-chromatographic analysis of ficaprenol and dolichol (1977)

A high-performance liquid-chromatographic method was devised which is capable of resolving the p-nitrobenzoyl derivatives of polyprenols containing 35-110 or more carbon atoms. This procedure was used for the determination of ficaprenol and pig liver dolichol composition and can be applied to mixtures of polyprenols as an analytical or preparative technique.
FPGA-based evaluation platform for disaggregated computing (2017)

Disaggregated computing aims at overcoming the problem of fixed resource proportionality in existing infrastructures while advancing resource allocation to virtual machines, which is currently restricted by the physical boundaries of a server tray. Organizing resources into large homogeneous pools (e.g., compute, memory, accelerators, etc) enables the demand-driven, fine-grained allocation of resources, effectively leading to improved resource utilization and significant power savings. However, the success of this approach relies on how efficiently the underlying resources are utilized by the software application. To facilitate software development in disaggregated computing environments, we introduce a versatile multi-FPGA evaluation platform that can serve as an early exploration tool for the involved trade-offs and execution alternatives given the application at hand. To increase functionality of the proposed development/evaluation platform, we consider three types of building blocks, namely compute, memory, and accelerator ones, providing the developer with the option to instantiate and interconnect them in proportion to the application demands, thus facilitating both compute- and memory-intensive applications. We have implemented a fully fledged prototype platform, based on three interconnected Zynq boards, and rely on a thin user-level API to allocate compute and memory resources on remote blocks, transfer data, and deploy reconfigurable accelerators. As a case study, we employ one of the Seven Dwarfs of Symbolic Computation, the matrix multiply benchmark.
Breakdown of Gases Below Paschen Minimum: Basic Design Data of High-Voltage Equipment (1969)

For the region pd<(pd)min, breakdown characteristics U2 = f(pd) are presented for both the noble and the more important molecular gases He, Ne, A, Kr, Xe, N2, H2, NH3, air, CO2, O2 (and Hg), particularly giving the probability of breakdown on which they are based, so that they can be used for dimensioning the relevant equipment. The design of vessel and electrode geometry which were introduced to determine these characteristics, and which have been tested up to a peak voltage of several hundred kilovolts, made it possible to study and describe the shape of the breakdown and flashover voltages relative to one another at pressures down to high vacuum (region of vacuum breakdown). They also provide an overall picture of the constructional facilities existing within the four following regions of ultimate stress, in which the breakdown voltage is determined by the ultimate electrical stressing of 1) the electrode surface (vacuum breakdown), 2) the insulator inside wall (internal flashover), 3) the insulator outside wall (external flashover), and 4) the gas path (Paschen breakdown). To express the probability of breakdown between 100 percent certainty (W = 1) and complete freedom from breakdown (W = 0), Poisson's formula may be used for the various breakdown mechanisms, i. e., for values of pd close to the respective kink and in the kinked part of the lefthand leg of the Paschen curve (regions 1-4 in Fig. 2), the value μbeing proportional to the peak value of the applied voltage Û.
Feedback Control Architecture and Design Methodology for Service Delay Guarantees in Web Servers (2006)

This paper presents the design and implementation of an adaptive Web server architecture to provide relative and absolute connection delay guarantees for different service classes. The first contribution of this paper is an adaptive architecture based on feedback control loops that enforce desired connection delays via dynamic connection scheduling and process reallocation. The second contribution is the use of control theoretic techniques to model and design the feedback loops with desired dynamic performance. In contrast to heuristics-based approaches that rely on laborious hand-tuning and testing iteration, the control theoretic approach enables systematic design of an adaptive Web server with established analytical methods. The adaptive architecture has been implemented by modifying an Apache server. Experimental results demonstrate that the adaptive server provides robust delay guarantees even when workload varies significantly.
<p>Clinical evidence on the efficacy and tolerability of a topical medical device containing benzoylperoxide 4%, retinol 0.5%, mandelic acid 1% and lactobionic acid 1% in the treatment of mild facial acne: an open label pilot study</p> (2019)

<b>Background:</b> Acne is a debilitating disorder that requires proper treatment depending on the clinical manifestations and pathogenetic factors, among which hyper-keratinization, seborrhea and bacterial proliferation. Combining active ingredients targeting the different mediators of acne pathogenesis may yield optimal outcomes. <b>Purpose:</b> The purpose of this study was to evaluate the clinical effectiveness, safety and tolerability of a new topical medical device in cream containing benzoylperoxide 4%, pure retinol 0.05%, palmitate retinol 0.5%, mandelic acid 1% and glycyrrhetic acid on patients with mild acne. <b>Patients and methods:</b> Twenty consecutive patients of both sexes with mild acne were included in the study. The topical treatment was self-applied twice a day for 12 weeks. Evaluations included: Global Acne Grading System (GAGS); inflammatory and non-inflammatory lesions count; reflectance confocal microscopy; seborrhea and hydration degree; photographic documentation; a questionnaire to assess tolerability. <b>Results:</b> The GAGS score showed a 39% reduction from T0 to T1 and 69.20% from T0 to T2. The count of comedonic lesions showed a 44% reduction from T0 to T1 and 65% from T0 to T2. The count of papular lesions diminished by 49.4% from T0 to T1 and by 62% from T0 to T2. The count of pustular lesions decreased by 43% from T0 to T1 and by 80% from T0 to T2. Improvement of hydration and a decrease of seborrhea degree were even observed. These clinical results were confirmed by reflectance confocal microscopy exam. <b>Conclusion:</b> The topical medical device has shown to be clinically effective and well tolerated for the treatment of mild acne. Side effects were mild, transient and well tolerated. The results of our study demonstrated a high tolerability of this new combination of benzoylperoxide 4% and retinol. Furthermore, our results suggested that the studied compound could be considered as a "maintenance treatment" after specific pharmacological treatment, even in more severe types of acne.
Literature Data May Underestimate the Actual Antioxidant Capacity of Cereals (2005)

Several recent articles have reported a significant antioxidant capacity of cereal products, determined in methanolic and ethanolic extracts. The aim of this work was to conduct an assessment of the antioxidant capacity of cereals using both chemical and in vitro digestive enzymatic extraction of antioxidants. Ferric reducing power (FRAP) and free radical scavenging capacity (DPPH) methods were used to determine the antioxidant capacity in wheat flour, bread, raw and boiled rice, wheat bran, and oat bran. The most efficient antioxidant extraction was achieved by using successively acidic methanol/water (50:50 v/v, pH 2) and acetone/water (70:30 v/v). The antioxidant capacity in these extracts ranged from 1.1 to 4.4 micromol Trolox/g dw. A significant amount of hydrolyzable phenolics with a high antioxidant capacity (from 5 to 108 micromol Trolox/g dw) was found in the residues of this aqueous-organic extraction. The antioxidant capacities of these nonextractable polyphenols are usually ignored in the literature, although they may have an antioxidant role in the gastrointestinal tract, especially after colonic fermentation, and may be fermentated to active metabolites. On the other hand, in vitro digestive enzymatic extracts obtained by enzymatic treatments that mimic conditions in the gastrointestinal tract showed that the amount of antioxidants released by the cereal matrix into the human intestine may be higher than the one that can be expected from measurements in the usual aqueous-organic extracts.
Association Between SSRI Use and Hip Fractures and the Effect of Residual Confounding Bias in Claims Database Studies (2004)

Epidemiologic claims data studies tend to overestimate the relation between antidepressant use and hip fractures. However, after correcting for such bias, a significant association persists.
Neural regulation of sex pheromone biosynthesis in <i>Heliothis</i> moths (1989)

Pheromone biosynthesis in females of Heliothis zea is regulated endogenously by a neuropeptide produced in the subesophageal ganglion. We have found that the ventral nerve cord must be intact for normal induction of pheromone biosynthesis and that pheromonotropic activity is associated with extracts of the abdominal nerve cord, but only during the period when pheromone is produced. We did not find evidence of pheromonotropic activity in hemolymph obtained from females that were producing pheromone. Extracts of the brain-subesophageal ganglion complex, which contain pheromone biosynthesis activating neuropeptide (PBAN), induced pheromone biosynthesis when applied to the terminal abdominal ganglion only if nerves from this ganglion to the pheromone gland were intact. Brain-subesophageal ganglion extracts did not induce biosynthesis when applied directly to the pheromone glands in vitro. From our results, we conclude that the target site of PBAN is not the pheromone gland but the terminal abdominal ganglion, and we hypothesize that the abdominal nerve cord transports PBAN to the terminal abdominal ganglion.
Shorter Notices (1990)

Journal Article Shorter Notices Get access OLIVE ANDERSON OLIVE ANDERSON Queen Mary & Westfield CollegeLondon Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume CV, Issue CCCCXVII, October 1990, Pages 1061-b–1063, https://doi.org/10.1093/ehr/CV.CCCCXVII.1061-b Published: 01 October 1990
Level of data-a concept for knowledge discovery in information spaces (1998)

The visualization of large volumes of abstract information requires mechanisms to support the user by knowledge discovery. Therefore, we have developed the "level of data" concept, in which the abstract nature of the data and the diverse user community has been taken into account. By using the "iceberg" metaphor, we classified the information space into several layers. The different backgrounds and analysis purposes of the users yield various views on the data. With these different perspectives on the iceberg, the levels of data can be pointed out. For proving the level-of-data concept, we developed a system for the interactive visualization of share prices as a representative example of abstract information. With the integration of this concept, it is possible that any user can perform any analysis within a single system.
A 3D Real‐Scale, Biomimetic, and Biohybrid Model of the Blood‐Brain Barrier Fabricated through Two‐Photon Lithography (2017)

The investigation of the crossing of exogenous substances through the blood-brain barrier (BBB) is object of intensive research in biomedicine, and one of the main obstacles for reliable in vitro evaluations is represented by the difficulties at the base of developing realistic models of the barrier, which could resemble as most accurately as possible the in vivo environment. Here, for the first time, a 1:1 scale, biomimetic, and biohybrid BBB model is proposed. Microtubes inspired to the brain capillaries were fabricated through two-photon lithography and used as scaffolds for the co-culturing of endothelial-like bEnd.3 and U87 glioblastoma cells. The constructs show the maturation of tight junctions, good performances in terms of hindering dextran diffusion through the barrier, and a satisfactory trans-endothelial electrical resistance. Moreover, a mathematical model is developed, which assists in both the design of the 3D microfluidic chip and its characterization. Overall, these results show the effective formation of a bioinspired cellular barrier based on microtubes reproducing brain microcapillaries to scale. This system will be exploited as a realistic in vitro model for the investigation of BBB crossing of nanomaterials and drugs, envisaging therapeutic and diagnostic applications for several brain pathologies, including brain cancer.
Effect of high-pressure deuterium oxide annealing on Al<inf>2</inf>O<inf>3</inf> deposited by plasma-assisted atomic layer deposition at low temperature (2012)

Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> thin films were deposited by plasma-assisted atomic layer deposition (PA-ALD), which can have the advantage of low temperature process. Then high pressure deuterium oxide annealing (HPDOA) was performed for reforming qualities of the PA-ALD Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> . The leakage current and the breakdown field of metal-oxide-semiconductor capacitors with the Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> film as the gate insulator were improved after HPDOA. In this study, HPDOA is found to be useful for reforming the Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> thin film even if it was deposited by PA-ALD.
Phase I study of recombinant human granulocyte-macrophage colony-stimulating factor in patients with bone marrow failure and malignancy. (1988)

Twenty-five patients with malignancy and/or bone marrow failure were treated with recombinant human granulocyte macrophage colony-stimulating factor (rh GM-CSF) (specific activity 5 x 10(7) units/mg, purity greater than 95%) given by continuous intravenous infusion at various fixed dose levels (15-500 micrograms/m2/day), as part of a phase I study. Treatment was associated with marked increases in white blood cell counts (2-70 fold), consisting mainly of neutrophilic granulocytes. Significant increases were also observed in eosinophils, monocytes and lymphocytes. In addition six patients had multilineage responses characterized by increases in platelet counts (greater than 2 fold and greater than 100,000/mm3) and reticulocyte counts (greater than 2 fold). Three of these 6 patients did not require red cell or platelet transfusion for 17 to 37 weeks. Treatment also resulted in an increase in bone marrow cellularity and myeloid: erythroid cell ratio. The common side effects were constitutional symptoms and bone pain. These findings demonstrate that rh GM-CSF is well tolerated when given by continuous IV infusion and is a potent stimulator of hematopoiesis in vivo.
Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose‐response study (2003)

SUMMARY Daytime performance changes were examined during chronic sleep restriction or augmentation and following subsequent recovery sleep. Sixty‐six normal volunteers spent either 3 ( n = 18), 5 ( n = 16), 7 ( n = 16), or 9 h ( n = 16) daily time in bed (TIB) for 7 days (restriction/augmentation) followed by 3 days with 8 h daily TIB (recovery). In the 3‐h group, speed (mean and fastest 10% of responses) on the psychomotor vigilance task (PVT) declined, and PVT lapses (reaction times greater than 500 ms) increased steadily across the 7 days of sleep restriction. In the 7‐ and 5‐h groups speed initially declined, then appeared to stabilize at a reduced level; lapses were increased only in the 5‐h group. In the 9‐h group, speed and lapses remained at baseline levels. During recovery, PVT speed in the 7‐ and 5‐h groups (and lapses in the 5‐h group) remained at the stable, but reduced levels seen during the last days of the experimental phase, with no evidence of recovery. Speed and lapses in the 3‐h group recovered rapidly following the first night of recovery sleep; however, recovery was incomplete with speed and lapses stabilizing at a level comparable with the 7‐ and 5‐h groups. Performance in the 9‐h group remained at baseline levels during the recovery phase. These results suggest that the brain adapts to chronic sleep restriction. In mild to moderate sleep restriction this adaptation is sufficient to stabilize performance, although at a reduced level. These adaptive changes are hypothesized to restrict brain operational capacity and to persist for several days after normal sleep duration is restored, delaying recovery.
Division Unit for Binary Integer Decimals (2009)

In this work, we present a radix-10 division unit that is based on the digit-recurrence algorithm and implements binary encodings (binary integer decimal or BID) for significands. Recent decimal division designs are all based on the binary coded decimal (BCD) encoding. We adapt the radix-10 digit-recurrence algorithm to BID representation and implement the division unit in standard cell technology. The implementation of the proposed BID division unit is compared to that of a BCD based unit implementing the same algorithm. The comparison shows that for normalized operands the BID unit has the same latency as the BCD unit and reduced area, but the normalization is more expensive when implemented in BID.
A new recording raingauge (1951)

An automatic siphon raingauge is described. The instrument is a floatgauge which when filled to a certain level is emptied by a tilting tube. The construction makes it impossible for preliminary dribbling of the rainwater to occur. The instrument has few moving parts and its functioning cannot be easily spoiled by dirt or corrosion.