gebhart/patrepeval huggingface dataset:
Automated micromanipulation for a microhand with All-In-Focus imaging system (2011)

For potential applications in bioscience, a two-fingered microhand with dexterous manipulation capability was developed. This microhand system could perform dexterous tasks such as cell rotation, single cell pick-and-place, cell patterning, and measurement of mechanical properties of living cells. However, it is a tedious task to manipulate micro objects manually. In order to improve the efficiency of the system, automated micromanipulation is required. This paper describes how to automate micromanipulation for this two-fingered microhand so that it can perform desired tasks more efficiently, more accurately, and faster. By integrating an All-In-Focus imaging system to the microhand system, 3D positions of the two microfinger tips and micro target objects can be obtained. These 3D positions are necessary for the microhand to handle the target object automatically. We demonstrate this capability by a pick-and-place task with multi-sized microspheres. Short time for object grasping and success rate over 70% for all cases could be achieved.
Halofuginone for fibrosis, regeneration and cancer in the gastrointestinal tract (2014)

Organ fibrosis and architectural remodeling can severely disrupt tissue function, often with fatal consequences. Fibrosis is the end result of chronic inflammatory reactions induced by a variety of stimuli, and the key cellular mediator of fibrosis comprises the myofibroblasts which, when activated, serve as the primary collagen-producing cells. Complex links exist between fibrosis, regeneration and carcinogenesis, and the concept that all organs contain common tissue fibrosis pathways that could be potential therapeutic targets is an attractive one. Because of the major impact of fibrosis on human health there is an unmet need for safe and effective therapies that directly target fibrosis. Halofuginone inhibits tissue fibrosis and regeneration, and thereby affects the development of tumors in various tissues along the gastrointestinal tract. The high efficacy of halofuginone in reducing the fibrosis that affects tumor growth and tissue regeneration is probably due to its dual role in inhibiting the signaling pathway of transforming growth factor β, on the one hand, and inhibiting the development of Th17 cells, on the other hand. At present halofuginone is being evaluated in a clinical trial for other fibrotic indication, and any clinical success in that trial would allow the use of halofuginone, also for all other fibrotic indications, including those of the gastrointestinal tract.
Mass Spectrometry Based Proteomic Profiling for Pancreatic Cancer (2015)

No abstract available. Image: Mass spectrometer schematic (Wikimedia Commons, by Devon Fyson)
Development of a Marine Riser Gas Management System (2012)

Abstract Drilling offshore oil and gas wells has become increasingly challenging as water and well depths have increased. In these areas drilling hazards resulting from narrow margins between pore and fracture pressures, pore pressure uncertainty, pore pressure regression, high pressure and high temperature have resulted in significant additional cost due to the time required to rectify problems associated with these hazards. As a consequence, industry has focused its efforts on developing mitigations to these challenges. Typically these developments have tended to focus on down hole solutions such as Managed Pressure Drilling and Dual Gradient Drilling; developments in drilling fluid management technologies and wellbore strengthening etc. One area which has not received as much focus recently is that of managing the drilling process and in particular the unique aspects relatedto working in deep water from Mobile Offshore Drilling Units. In particular theprobability of relatively small undetected hydrocarbon influxes abovethe subsea BOP. Depending on the drilling fluid and influx composition, unconstrained expansion of the influx (gas) may exceed the surface equipment handling capability (i.e. diverter system, capability and performance). Additionally, depending on the bubble pointof the drilling fluid / influx composition unconstrained evolution of fluid fromthe riser can result in a significant reduction in riser fluid level and thereforereduction in hydrostatic pressure which may impact the riser BOP system as wellas increase the probability of additional influxes entering the wellbore. This paper describes the design, development and construction of a riser gas managementsystem which addresses these concerns.
Excavación mediante tuneladora sin escudo: Túnel de Paracuellos (Calatayud) del AVE Madrid-Barcelona-frontera Francesa (2003)

El tunel de Paracuellos se situa en la linea del tren de alta velocidad Madrid - Zaragoza - Lleida - Barcelona - Frontera Francesa, entre los terminos municipales de Huermeda y Paracuellos, en las proximidades de Calatayud, en la provincia de Zaragoza. Tiene una longitud aproximada de 4,7 km y un diametro de excavacion de 12,20 m. Fue adjudicado a la U.T.E. formada por Fomento de Construcciones y Contratas S.A. y NECSO, quien subcontrato su ejecucion a la empresa suiza Murer, de experiencia contrastada en este tipo de obras en su pais de origen.
Actualmente en ejecucion, se incluye en el Plan de Infraestructuras 2000-2007.
Tc-99m-diethyl-IDA imaging: clinical evaluation in jaundiced patients. (1980)

Hepatobiliary imaging with Tc-99m-N,alpha-(2,6-diethylacetanilide)-iminodiacetic acid (Tc-diethyl-IDA) was performed in 91 jaundiced patients with documented hepatobiliary damage and serum total bilirubin up to 35 mg/dl. There were 56 patients with obstructive jaundice and 35 with hepatocellular disease. Correct discrimination between hepatocellular and obstructive jaundice was possible with an overall accuracy of 90%. Agreement with the final clinical diagnosis was obtained in 97% of patients with hepatocellular disease, and in 86% of patients with obstructive jaundice. The reliability of the test was inversely related to the serum bilirubin concentration. The incidence of true-positive scans dropped from 93% for bilirubin levels below 10 mg/dl to 83% for bilirubin between 10 and 20 mg/dl. Above 20 mg/dl, the demonstration of a mechanical obstruction was possible in only one out of the four patients with obstructive jaundice. The high predictive values of the test illustrate that Tc-diethyl-IDA imaging constitutes a reliable method to demonstrate an obstructive cause for the jaundice as long as the bilirubin level remains below 20 mg/dl.
The External Urethral Barrier for Stress Incontinence (1999)

In Brief Objective To assess the efficacy and safety of an external urethral barrier for the management of mild to moderate stress urinary incontinence in adult women. Methods Four hundred eleven women with the symptom of stress urinary incontinence in 12 United States centers participated. Additional inclusion and exclusion criteria were applied before protocol device use, and ultimately 390 subjects began device use. Outcome measures for efficacy and safety were assessed. Efficacy was evaluated by the number of leakage episodes using a voiding diary, subjective urinary leakage severity, incontinence impact scores, and pad testing. Safety was evaluated by symptom assessment, urinalysis, urine culture, measurement of postvoid residual urine volume, vulvar cytology, vaginal culture, and (n = 81) cystometric testing. Results Efficacy was indicated by statistically significant reductions in the number of leakage episodes, subjective leakage severity scores, incontinence impact scores, and pad-test loss during device use. The data also indicated that the device was safe, as evidenced by the lack of statistically significant changes in the percentage of subjects with urinary tract infections during device use or in postvoid residual urine volume and cystometric indices. Symptoms of vulvar irritation or lower urinary tract discomfort occurred in a small percentage of subjects but were generally transient, and only three women discontinued using the device. Conclusion The external urethral barrier appears to be a safe nonsurgical alternative to absorbent products for the management of mild to moderate stress urinary incontinence in adult women. The external urethral barrier is a safe and effective treatment option for women with mild to moderate stress urinary incontinence.
Hyaluronic Acid-<i>N</i>-hydroxysuccinimide:  A Useful Intermediate for Bioconjugation (2001)

Hyaluronic acid (HA) is an abundant nonsulfated glycosaminoglycan component of synovial fluid and the extracellular matrix. HA is an important building block for biocompatible and biointeractive materials with applications in drug delivery, tissue engineering, wound repair, and viscosupplementation. Herein we describe the synthesis and characterization of HA-N-succinimide, an activated ester of the glucuronic acid moiety. This HA-active ester intermediate is a precursor for fluorescent probes, drug-polymer conjugates, and cross-linked hydrogels. As a demonstration, we used HA-NHS to prepare HA-BODIPY by coupling with the hydrazide derivative of the fluor. Intracellular uptake of HA-BODIPY into human ovarian cancer cells, which overexpress cell-surface HA receptors, was visualized using confocal microscopy.
Mechanisms and management of neuropathic pain in cancer. (2006)

Neuropathic pain is a common syndrome in people with cancer. The pathophysiology of such pain in cancer is not fully understood, often leading to poor management and needless suffering. Knowledge regarding the potential mechanisms of neuropathic pain, skill in appropriate history-taking and physical-assessment techniques, and awareness of the more common neuropathic pain syndromes and their etiologies, as well as familiarity with the role of new pharmacologic interventions, will allow healthcare professionals to provide better relief of neuropathic pain. At present,a variety of agents are used to treat neuropathic pain situations. Rehabilitation of persons with neuropathic pain should be part of overall management and should address functional impairment and safety factors to prevent accidents resulting from sensory loss.
Dental care for cancer patients: a survey of Texas dental school graduates. (1990)

A survey of recent Texas dental school graduates regarding their preparedness for addressing the oral health care needs of cancer patients in their practices suggests several trends. Many graduates (26%) do not feel adequately prepared to manage and provide oral care for cancer patients. Over 95% of the dentists surveyed expressed interest in locally sponsored continuing education courses on the oral health care of cancer patients. Clearly, both predoctoral and postdoctoral dental education must recognize the need for formalized instruction on the oral cre of cancer patients if general dentists are to provide high-quality, comprehensive dental care for these patients.
THE CRYSTALLIZATION OF MENTHOL. (1917)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTTHE CRYSTALLIZATION OF MENTHOL.Fred E. WrightCite this: J. Am. Chem. Soc. 1917, 39, 8, 1515–1524Publication Date (Print):August 1, 1917Publication History Published online1 May 2002Published inissue 1 August 1917https://pubs.acs.org/doi/10.1021/ja02253a001https://doi.org/10.1021/ja02253a001research-articleACS PublicationsRequest reuse permissionsArticle Views711Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hot Anchors: A Heuristic Anchors Sampling Method in RCNN-Based Object Detection (2018)

In the image object detection task, a huge number of candidate boxes are generated to match with a relatively very small amount of ground-truth boxes, and through this method the learning samples can be created. But in fact the vast majority of the candidate boxes do not contain valid object instances and should be recognized and rejected during the training and evaluation of the network. This leads to extra high computation burden and a serious imbalance problem between object and none-object samples, thereby impeding the algorithm's performance. Here we propose a new heuristic sampling method to generate candidate boxes for two-stage detection algorithms. It is generally applicable to the current two-stage detection algorithms to improve their detection performance. Experiments on COCO dataset showed that, relative to the baseline model, this new method could significantly increase the detection accuracy and efficiency.
Studies on lipopeptide biosynthesis by<i>Bacillus subtilis</i>: Isolation and characterization of iturin<sup>â</sup>, surfactin<sup>+</sup>mutants (1995)

Two mutant strains, M35 and M89, were obtained by UV irradiation from a wild-type Bacillus subtilis producing iturin and surfactin. Sporulation and surfactin production were similar in both mutants and in the parent strain, while the iturin production of M35 was 300-fold less than that of the wild-type strain; M89 did not produce any iturin. The analysis of the incorporation of sodium [1-14C]acetate into cellular lipids and lipopeptides showed that M89 still synthesized beta-amino fatty acids, the lipid moiety of iturin.
Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor. (1992)

Epidermal growth factor (EGF) reproduces many of the effects of estrogen on the murine female reproductive tract and may partially mediate estrogen-induced growth and differentiation. This study was performed to investigate the mechanism by which EGF elicits estrogen-like actions in the whole animal. EGF was administered to adult ovariectomized mice by slow release pellets implanted under the kidney capsule. The induction of uterine DNA synthesis and phosphatidylinositol lipid turnover by EGF or administration of diethylstilbestrol (5 micrograms/kg), a potent estrogen, was attenuated by the estrogen receptor antagonist ICI 164,384. Furthermore, EGF mimicked the effects of estrogen on enhanced nuclear localization of the estrogen receptor and the formation of a unique form of the estrogen receptor found exclusively in the nucleus. These results suggest that EGF may induce effects similar to those of estrogen in the mouse uterus by an interaction between the EGF signaling pathway and the classical estrogen receptor. The demonstration of cross-talk between polypeptide growth factors and steroid hormone receptors may be of importance to our understanding of the regulation of normal growth and differentiation as well as the mechanisms of transmission of extracellular mitogen signals to the nucleus.
Optical switching in polymer gels (1996)

Soft materials have long been sought after for use in devices such as actuators, artificial muscles, separators, switches, sensors, memories, and so forth. We developed a soft, optically transparent material using polymer gels that can not only be activated by visible light (switched on) but also deactivated (switched off) by altering the local environment using three different means: pH, temperature, and light. This copolymer gel is a covalently cross-linked network of N-isopropylacrylamide, sodium acrylate, and a chromophore, which is found to undergo phase transitions exhibiting large hysteresis in the degree of swelling in response to pH, temperature, and light. In each system, between the transitions for swelling and shrinking, the gel can show either a swollen or a collapsed state, which can be selected according to the history of the variables. It has been established that a thermoresponsive gel with chromophore exhibits a local volume phase transition upon illumination with visible light. By making use of this phenomenon, we have successfully controlled the phase in which a gel exists with visible light: Without light illumination the gel stays in the swollen state. Upon illumination beyond a threshold intensity, however, a volume transition is locally induced, thereby forming a material in which both phases coexist stably for at least several hours after the light source has been removed. The phenomenological stability of the material in the coexistence state is discussed on the basis of the Landau theory.
SART‐Type Image Reconstruction from a Limited Number of Projections with the Sparsity Constraint (2010)

Based on the recent mathematical findings on solving the linear inverse problems with sparsity constraints by Daubechiesx et al., here we adapt a simultaneous algebraic reconstruction technique (SART) for image reconstruction from a limited number of projections subject to a sparsity constraint in terms of an invertible compression transform. The algorithm is implemented with an exemplary Haar wavelet transform and tested with a modified Shepp-Logan phantom. Our preliminary results demonstrate that the sparsity constraint helps effectively improve the quality of reconstructed images and reduce the number of necessary projections.
Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies (2016)

Toreforant was not effective in phase IIb testing.
Performance evaluation of processor allocation algorithms for parallel query execution (1997)

Article Performance evaluation of processor allocation algorithms for parallel query execution Share on Author: Kevin H. Liu Department of Computer and Mathematical Sciences, Victoria University of Technology, Ballarat Road, Footscray, PO Box 14428 MCMC, Melbourne, Victoria 8001, Australia Department of Computer and Mathematical Sciences, Victoria University of Technology, Ballarat Road, Footscray, PO Box 14428 MCMC, Melbourne, Victoria 8001, AustraliaView Profile Authors Info & Claims SAC '97: Proceedings of the 1997 ACM symposium on Applied computingApril 1997 Pages 393–402https://doi.org/10.1145/331697.332320Online:01 April 1997Publication History 1citation411DownloadsMetricsTotal Citations1Total Downloads411Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
BITS2019: the sixteenth annual meeting of the Italian society of bioinformatics (2020)

The 16th Annual Meeting of the Bioinformatics Italian Society was held in Palermo, Italy, on June 26-28, 2019. More than 80 scientific contributions were presented, including 4 keynote lectures, 31 oral communications and 49 posters. Also, three workshops were organised before and during the meeting. Full papers from some of the works presented in Palermo were submitted for this Supplement of BMC Bioinformatics. Here, we provide an overview of meeting aims and scope. We also shortly introduce selected papers that have been accepted for publication in this Supplement, for a complete presentation of the outcomes of the meeting.
Observation of Raman emission in silicon waveguides at 154 µm (2002)

We report the first measurements of spontaneous Raman scattering from silicon waveguides. Using a 1.43 m pump, both forward and backward scattering were measured at 1.54 m from Silicon-On-Insulator (SOI) waveguides. From the dependence of the Stokes power vs. pump power, we extract a value of (4.1 +/- 2.5) x 10-7 cm-1 Sr-1 for the Raman scattering efficiency. The results suggest that a silicon optical amplifier is within reach. The strong optical confinement in silicon waveguides is an attractive property as it lowers the pump power required for the onset of Raman scattering. The SiGe material system is also discussed.
Harmonic Scalpel Tonsillectomy versus Monopolar Diathermy Tonsillectomy: A Prospective Study (2008)

For tonsillectomy, the ultrasonic harmonic scalpel has been purported to cause less tissue injury and postoperative morbidity while providing adequate levels of hemostasis. We undertook a prospective study to compare outcomes in 162 patients who had undergone harmonic scalpel tonsillectomy and 40 patients who had undergone monopolar diathermy tonsillectomy over a 33-month period. We found that patients in the harmonic scalpel group experienced significantly less intraoperative bleeding (5.0 vs. 16.5 ml; p < 0.0001). There was no clinically significant difference between the groups with respect to (1) the amount of operating time, (2) the incidence of postoperative nausea and vomiting, dysphonia, and primary or secondary bleeding, and (3) the amount of time patients needed to resume normal diet and activities.
Multichannel Eigenspace Beamforming in a Reverberant Noisy Environment With Multiple Interfering Speech Signals (2009)

In many practical environments we wish to extract several desired speech signals, which are contaminated by nonstationary and stationary interfering signals. The desired signals may also be subject to distortion imposed by the acoustic room impulse responses (RIRs). In this paper, a linearly constrained minimum variance (LCMV) beamformer is designed for extracting the desired signals from multimicrophone measurements. The beamformer satisfies two sets of linear constraints. One set is dedicated to maintaining the desired signals, while the other set is chosen to mitigate both the stationary and nonstationary interferences. Unlike classical beamformers, which approximate the RIRs as delay-only filters, we take into account the entire RIR [or its respective acoustic transfer function (ATF)]. The LCMV beamformer is then reformulated in a generalized sidelobe canceler (GSC) structure, consisting of a fixed beamformer (FBF), blocking matrix (BM), and adaptive noise canceler (ANC). It is shown that for spatially white noise field, the beamformer reduces to a FBF, satisfying the constraint sets, without power minimization. It is shown that the application of the adaptive ANC contributes to interference reduction, but only when the constraint sets are not completely satisfied. We show that relative transfer functions (RTFs), which relate the desired speech sources and the microphones, and a basis for the interference subspace suffice for constructing the beamformer. The RTFs are estimated by applying the generalized eigenvalue decomposition (GEVD) procedure to the power spectral density (PSD) matrices of the received signals and the stationary noise. A basis for the interference subspace is estimated by collecting eigenvectors, calculated in segments where nonstationary interfering sources are active and the desired sources are inactive. The rank of the basis is then reduced by the application of the orthogonal triangular decomposition (QRD). This procedure relaxes the common requirement for nonoverlapping activity periods of the interference sources. A comprehensive experimental study in both simulated and real environments demonstrates the performance of the proposed beamformer.