gebhart/patrepeval huggingface dataset:
Naltrexone Blocks Acquisition of Voluntary Ethanol Intake in Rats (1997)

The effects of naltrexone (NTX) on the acquisition of ethanol drinking was assessed in rats. NTX (0, 2.5, 5.0, or 10.0 mg/kg) was administered to rats presented with an ascending series of ethanol concentrations (2%, 4%, 6%, and 8% v/v) and water. The 2.5 and 10 mg/kg doses of NTX attenuated the acquisition of voluntary drinking of 8% ethanol, but the 5.0 mg/kg dose of NTX had no effect on ethanol intake. The acquisition paradigm was repeated in experiment 2 with naïve animals that received 0, 5.0, or 7.5 mg/kg of NTX. Neither dose of NTX affected ethanol intake, preference for alcohol, or water intake. Total fluid intake was suppressed in the NTX groups, but only on the second presentations of the 2% and 6% concentrations of ethanol. We suggest that the 2.5 and 10 mg/kg doses of NTX may have attenuated the acquisition of ethanol drinking by at least two different behavioral mechanisms.
The exponential radon transform and projection filtering in radiotherapy planning (1995)

Abstract The mathematical problem of generating a desired dose distribution in a patient who has to undergo external beam radiotherapy is closely related to the problem of reconstructing an image from its projections. Under some simplifying assumptions the theory of the exponential Radon transform as developed for SPECT image reconstruction can be successfully applied to the field of radiotherapy. This results in a projection‐filtering algorithm for the calculation of optimal beam profiles. The method yields analytical solutions for circular and triangular dose distributions, and combinations thereof. Practical solutions for arbitrary cases can be found numerically. The problem of unphysical negative values in the calculated beam profiles is solved by a method combining “cutting off” and “shifting”.
Elevated plasma levels of oxytocin in obese subjects before and after gastric banding. (1989)

Impaired glucose tolerance and hyperinsulinaemia are common features of obesity. Since oxytocin has been shown to influence glucose metabolism and insulin secretion, the objective of the present study was to investigate whether the plasma level of oxytocin is elevated in obese subjects and if so, whether it is affected by weight reduction following gastric banding. Repeated blood samples were collected in connection with ingestion of a liquid test meal from subjects weighing about 130 kg. Normal weight subjects were tested likewise. Further tests were performed on obese subjects 6 months after operation with gastric banding and a subsequent weight reduction of about 30 kg. Plasma levels of oxytocin were measured by radioimmunoassay. It was found that plasma levels of oxytocin were 4-fold higher in the obese subjects when compared to the control subjects. Analysis with high performance liquid chromatography demonstrated that the oxytocin-like material, as determined by radioimmunoassay, in extracted plasma from one obese subject coeluted with synthetic oxytocin standard. Ingestion of a test meal did not seem to influence oxytocin levels. The mean oxytocin level was equally elevated in male and female obese subjects. Following operation oxytocin levels decreased significantly, but were still significantly higher than in the control subjects. The mechanism behind the hyperoxytocinaemia and possible consequence of it remain obscure.
Diamond-shaped Ge and Ge0.9Si0.1 gate-all-around nanowire FETs with four {111} facets by dry etch technology (2015)

We propose a feasible pathway to scale the Ge MOSFET technology by using a novel diamond-shaped Ge and Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">09</sub> Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">01</sub> gate-all-around (GAA) nanowire (NW) FETs with four {111} facets. The device fabrication requires only simple top-down dry etching and blanket Ge epitaxy techniques readily available in mass production. The proposed dry etching process involves three isotropic/anisotropic etching steps with different Cl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /HBr ratios for forming the suspended diamond-shaped channel. Taking advantages of the GAA configuration, favorable carrier mobility of the {111} surface, nearly defect-free suspended channel, and improved dopant activation by incorporating Si, nFET and pFET with excellent performance have been demonstrated, including an I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> /I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> ratio exceeding 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> , the highest ever reported for Ge-based pFETs.
Preparation of 3‐(2<i>H</i>‐pyran‐2‐on‐6‐yl)indolizines and the diels‐alder reactions with some olefinic and acetylenic dienophiles (1991)

Abstract 3‐(2 H ‐Pyran‐2‐on‐6‐yl)indolizines 6a‐d were prepared by 1,3‐dipolar cycloaddition reactions of N ‐(2 H ‐pyran‐2‐on‐6‐yl)methylpyridinium bromides 5a,b with dimethyl acetylenedicarboxylate (DMAD). All of the cycloaddition reactions of 6b with N ‐phenylmaleimide, p ‐benzoquinone, and DMAD took place at the 2‐pyrone ring to give 3‐substituted indolizines.
Why does the electrical conductivity in PEDOT:PSS decrease with PSS content? A study combining thermoelectric measurements with impedance spectroscopy (2012)

Abstract We have investigated the electrical transport properties of poly(3,4‐ethylenedioxythiophen)/poly(4‐styrene‐sulfonate) (PEDOT:PSS) with PEDOT‐to‐PSS ratios from 1:1 to 1:30. By combining impedance spectroscopy with thermoelectric measurements, we are able to independently determine the variation of electrical conductivity and charge carrier density with PSS content. We find the charge carrier density to be independent of the PSS content. Using a generalized effective media theory, we show that the electrical conductivity in PEDOT:PSS can be understood as percolation between sites of highly conducting PEDOT:PSS complexes with a conductivity of 2.3 (Ωcm) −1 in a matrix of excess PSS with a low conductivity of 10 −3 (Ω cm) −1 . In addition to the transport properties, the thermoelectric power factors and Seebeck coefficients have been determined. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2012
Evaluation of lotion formulations on irritation using the modified forearm‐controlled application test method (2007)

The results indicated that this modification of the FCAT can be used to compare various lotion formulations for skin benefits and healing properties, and to rank qualitatively the benefits of various formulation options.
MDiET: Malware Detection in Encrypted Traffic (2019)

With the increasing adoption of end-to-end encryption in industrial systems, the risk of distributing hidden malware by exploiting encrypted channels gradually turns to a major concern. Due to encryption, the state-of-the-art, signature-based mechanisms might fail to detect malware sufficiently, thus new approaches are required. In this work, a method for malware detection in encrypted traffic based on Machine Learning is presented. A supervised learning approach is adopted and the efficiency of the solution is demonstrated by a set of exhaustive simulations. Further considerations for incorporating the proposed method in a reference industrial network are also discussed.
Effects of clay dispersion and content on the rheological, mechanical properties, and flame retardance of HDPE/clay nanocomposites (2007)

Abstract Full exfoliation of clay/high density polyethylene (HDPE) nanocomposites was successfully achieved with the aid of maleated HDPE (PE‐ g ‐MAn), by melt blending in a twin‐screw extruder employing a long residence time configuration. The morphology of the composites was determined using wide‐angle X‐ray diffraction and transmission electron microscopy. The effects of clay content and state of clay dispersion on the rheological, tensile properties, and flame retardancy of nanocomposites containing very small amounts of clay, in the range of 0.05–1.0 wt %, were investigated in this study. It was demonstrated that achieving a higher degree of exfoliation for nanosized clay particles is key to enhancing the rheological, mechanical, and flame retarding properties even when small amounts of clay (less than 1%) are used. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007
Position Self-Sensing Evaluation of Novel CW-IPMSMs With an HF Injection Method (2014)

This paper introduces two different novel designs of interior permanent-magnet synchronous machines with concentrated windings, which are attractive to a self-sensing control system. The new machines have some advantages: lower subharmonics of air-gap flux density and magnetomotive force and lower machine losses, including eddy current losses. The machines have been adapted for self-sensing applications by using a high-frequency (HF) injection method. The main machine parameters affecting the estimation accuracy are analyzed such as fundamental frequency saliencies, cross saturation, HF inductance, HF resistance, and harmonic distortion due to multisaliencies. The experimental results verify that the novel machines can reach very high performance with good self-sensing properties regarding the accuracy of the estimated position/speed of electric drives even without the multisaliency decoupling compensation method.
A rare premalignant prostate tumor epithelial cell syndecan-1 forms a fibroblast growth factor-binding complex with progression-promoting ectopic fibroblast growth factor receptor 1. (2001)

The abnormal appearance and age-dependent loss of resident fibroblast growth factor receptor-2 (FGFR2) and gain of activity of FGFR1 in epithelial cells is a hallmark of the slow progression to malignancy in some models of prostate cancer. Pericellular matrix heparan sulfate (HS) is an integral subunit of the FGFR tyrosine kinase complex that restricts activity in absence of FGF, facilitates binding of an activating FGF, and confers specificity for FGF isoforms. In this report, we isolated and purified HS proteoglycan (HSPG) from premalignant prostate tumor epithelial cells based on the ability of the HS chains to form a binary complex with immunoglobulin module II of the ectopic and progression-promoting FGFR1 that was competent to bind FGF. The FGFR1 affinity-purified product exhibited a specific activity of over 600 times that of crude cellular HSPG enriched from cell lysates by ion exchange chromatography. The purified preparation exhibited a single NH(2)-terminal sequence with 11 of 13 residues identical to syndecan-1. The activity of purified recombinant glutathione S-transferase-tagged syndecan-1 expressed in premalignant epithelial cells confirmed that syndecan-1 bears HS chains that exhibit the rare motif that forms the FGF-binding complex with ectopic FGFR1. These results are the first to identify by affinity purification a specific HSPG core protein, the HS chains of which act as an integral subunit of the FGFR complex. The results suggest that syndecan-1 provides HS chains in premalignant epithelial cells to both the FGFR2- and FGFR1-signaling complexes that are integral to their dual roles in progression to malignancy.
Enabling pervasive encryption through IBM Z stack innovations (2018)

Organizations are under tremendous pressure to protect the data in their enterprises. Strong walls and perimeter defenses are no longer viewed as adequate, and most organizations agree that encryption plays a vital role in protecting critical information. However, the practice of implementing an encryption strategy can vary greatly as organizations struggle with practical challenges of deploying encryption solutions. In this paper, we explain how innovations in the IBM Z stack, spanning hardware, firmware, operating systems, and middleware combine to help organizations address the challenges of protecting the data at the center of their enterprises using pervasive encryption, which can be enabled by policy and be transparent to applications.
3DIP: An iterative partitioning tool for monolithic 3D IC (2016)

CoolCube <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> is a monolithic 3D (M3D) technology offering a vertical density of integration 20 times higher than face to face copper hybrid bonding (F2F Cu-Cu), thanks to ultra-thin Monolithic Inter-tier Vias (MIVs). In this work, we propose a new partitioning tool exploiting this characteristic for 2-tier Cell-on-Cell ICs before placement. It is based on a fast and iterative algorithm that explores the space of solutions and minimizes the estimated cost of wires with balanced area between tiers without limiting the number of MIVs. A mathematical formulation of the 3D partitioning problem and a comprehensive framework, based on simulated annealing (SA) algorithm coupled with a dedicated cost function, are detailed and compared with Min-Cut (MC) partitions commonly used. It appears that our solution can decrease the estimated total cost of wires by 41% and 45% for the LDPC and FFT/AES units. It also reduces the total cost of wires by 30% to 44% compared to the MC algorithm for the same units and with no significant increase in runtime.
Diffraction and diffuse scattering from dielectric multilayers (1979)

First-order perturbation theory is used to evaluate diffuse scattering and grating diffraction from surfaces covered with dielectric multilayers. The scattering is caused by the grating profile or micro-roughness present at the multilayer interfaces. Particular emphasis is given to anomalous scattering effects which occur at so-called polarizing angles that are associated with the multilayer structures. Several numerical examples are given.
A bonding technique using hydrophilic SU-8 (2007)

In this study, we present a bonding technique for fabricating microfluidic devices with surfactant-added SU-8 (hydrophilic SU-8) as the structure. The technique is based on an adhesive wafer bonding process. The hydrophilic SU-8 plays the roles of both an adhesive layer (glue) as well as a structural layer. Due to its special feature, bonding with hydrophilic SU-8 could be conducted without pressurizing equipment. The material could define structure satisfactorily and it has a hydrophilic surface in a cured state, and has a good adhesion capability with various substrates (glass, silicon or PDMS) after oxygen plasma treatment. The performance of the material was verified by using the Raman spectroscopy to analyze the possible changes in chemical structure, measuring contact angle to characterize hydrophilicity and several tests to confirm the bonding capability. The effect of different parameters on the bonding has also been explored. 2D (one-layer hydrophilic SU-8) and 3D (two-layer hydrophilic SU-8) sandwich configurations were constructed using this bonding technique. The tests showed the bonding strength to be in the range of 2–14 kg cm−2 measured by the pull test, and the microchannels could stand up to 0.4 atm pressure drop in the hydrodynamic testing. The present material has good properties in bonding, and the procedure is fast, compatible and easily implementable with a standard photolithography. It is suitable for microstructure and microelectronics integration, and highly involved three-dimensional (3D) microstructures.
Structural characterization of polymer blends based on polysulfones (2004)

Abstract A series of blends with various compositions was prepared on the basis of polysulfone, polyethersulfone, and polyimide. These blends were characterized by different techniques, including Fourier transform IR spectroscopy, differential scanning calorimetry, dynamic mechanical analysis, and tensile stress–strain measurements. The results obtained allowed for certain conclusions regarding blend compatibility. In addition, the mechanical properties were subjected to an experimental test design to measure the blends for tensile break strength and Young's modulus with a computer program, which eventually enabled us to obtain the surface response equations of both properties and also to predict the optimum composition presenting the best mechanical behavior. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 92: 3030–3039, 2004
An IP multicast handoff scheme with focus on IGMP sourced latency (2003)

This paper focuses on the latency due to IGMP during inter-subnet handoffs in Mobile IP multicast networks and proposes a new method for this purpose. Pre-informing the neighbor subnets about the expected mobile hosts under the shadow cluster concept and triggering the preparation phase in advance are the fundamentals of the proposal. Performance improvement achieved through the method is discussed in the paper with the particular emphasis on QoS critical applications.
Cyclododecanol, Cyclododecanone, and Laurolactam (2000)

The article contains sections titled: 1. Cyclododecanol and Cyclododecanone 1.1. Properties 1.2. Production 1.3. Uses 2. Laurolactam 2.1. Properties 2.2. Production 2.3. Uses 3. Toxicology
Surface expression of mutated subunits of the high affinity mast cell receptor for IgE. (1990)

The mast cell receptor with high affinity for IgE consists of four transmembrane polypeptides which are held together by detergent-sensitive interactions: an IgE-binding alpha chain, a single beta chain, and a disulfide-linked dimer of gamma chains. Now that the cDNAs that code for each of the subunits have been isolated, it should be possible to probe by site-specific mutations, which portions of the receptor are critical for transmembrane signaling. One prerequisite for such studies is that the mutant receptors be expressible on the cell surface. We have explored this issue by transiently transfecting COS 7 cells with mutant subunits and assessing surface expression by IgE binding. Removal of any single cytoplasmic domain of the receptor's subunits had little influence on surface expression, and even receptors missing all five cytoplasmic domains were expressed, albeit less efficiently. Minor changes within the transmembrane domains (TMs) sometimes produced major effects and more drastic changes in the TMs ablated surface expression entirely. These data suggest that the TMs are critical loci for receptor display. Cys7 (residue 2 in the gamma TM) was shown to form the inter-gamma disulfide bond and to be nonessential for surface expression. By localizing this bond, residues in the TM of gamma that are buried in the interface between the gamma subunits could be predicted. Consistent with observations on other membrane proteins (Rees, D. C., DeAntonio, L., and Eisenberg, D. (1989) Science 245, 510-513), maximal interspecies conservation was observed for those residues in the gamma TM predicted to be buried. This was also true for those residues in the alpha and beta TMs predicted to be buried by analysis of the TM hydrophobic moments.
An ultra-fast fiber optic pressure sensor for blast event measurements (2012)

Soldiers who are exposed to explosions are at risk of suffering traumatic brain injury (TBI). Since the causal relationship between a blast and TBI is poorly understood, it is critical to have sensors that can accurately quantify the blast dynamics and resulting wave propagation through a helmet and skull that are imparted onto and inside the brain. To help quantify the cause of TBI, it is important to record transient pressure data during a blast event. However, very few sensors feature the capabilities of tracking the dynamic pressure transients due to the rapid change of the pressure during blast events, while not interfering with the physical material layers or wave propagation. In order to measure the pressure transients efficiently, a pressure sensor should have a high resonant frequency and a high spatial resolution. This paper describes an ultra-fast fiber optic pressure sensor based on the Fabry–Perot principle for the application of measuring the rapid pressure changes in a blast event. A shock tube experiment performed in US Army Natick Soldier Research, Development and Engineering Center has demonstrated that the resonant frequency of the sensor is 4.12 MHz, which is relatively close to the designed theoretical value of 4.113 MHz. Moreover, the experiment illustrated that the sensor has a rise time of 120 ns, which demonstrates that the sensor is capable of observing the dynamics of the pressure transient during a blast event.
Visual Analysis of Large Heterogeneous Social Networks by Semantic and Structural Abstraction (2006)

Social network analysis is an active area of study beyond sociology. It uncovers the invisible relationships between actors in a network and provides understanding of social processes and behaviors. It has become an important technique in a variety of application areas such as the Web, organizational studies, and homeland security. This paper presents a visual analytics tool, OntoVis, for understanding large, heterogeneous social networks, in which nodes and links could represent different concepts and relations, respectively. These concepts and relations are related through an ontology (also known as a schema). OntoVis is named such because it uses information in the ontology associated with a social network to semantically prune a large, heterogeneous network. In addition to semantic abstraction, OntoVis also allows users to do structural abstraction and importance filtering to make large networks manageable and to facilitate analytic reasoning. All these unique capabilities of OntoVis are illustrated with several case studies.
Transforming growth factor-beta blocks protein kinase-A-mediated iodide transport and protein kinase-C-mediated DNA synthesis in FRTL-5 rat thyroid cells. (1992)

Recent studies have shown that transforming growth factor-beta (TGF beta) alters DNA synthesis and iodide metabolism in human, porcine, and rat thyroid cells. In the present work we studied the mechanism of TGF beta action in FRTL-5 rat thyroid cells. The cells were treated with TGF beta in the presence of TSH, growth factors, and cellular modulators for various periods of time; then, [3H]thymidine incorporation and DNA content were measured as indicators of DNA synthesis, and [125I]iodide uptake was measured to assess cell function. TGF beta (10 ng/ml) inhibited TSH-induced DNA synthesis and iodide uptake. TGF beta also inhibited DNA synthesis induced by insulin-like growth factor-I, fibroblast growth factor, and endothelial cell growth factor. The protein kinase-A (PKA) activator 8-bromo-cAMP increased both iodide uptake and DNA synthesis; TGF beta inhibited 8-bromo-cAMP-induced [125I]iodide uptake, but not [3H]thymidine incorporation. The protein kinase-C (PKC) activator phorbol 12-myristate 13-acetate increased [3H]thymidine incorporation, and TGF beta inhibited this action of phorbol 12-myristate 13-acetate. The results show that activation of PKA or PKC increases DNA synthesis. TGF beta inhibited PKC-mediated, but not PKA-mediated, DNA synthesis in these cells. The results also show that TGF beta selectively inhibits PKA-mediated iodide uptake, but not PKA-mediated DNA synthesis. These findings suggest that TGF beta is a strong inhibitor of the proliferation and function of thyroid cells.