gebhart/patrepeval huggingface dataset:
Profiling-Based Hardware/Software Co-Exploration for the Design of Video Coding Architectures (2009)

The design of embedded hardware/software systems is often subject to strict requirements concerning its various aspects, including real-time performance, power consumption, and die area. Especially for data intensive applications, the number of memory accesses is a dominant factor for these aspects. In order to meet the requirements and design a well-adapted system, the software parts need to be optimized and an adequate system and processor architecture needs to be designed. In this paper, we focus on finding an optimized memory hierarchy for bus-based architectures. Additionally, useful instruction set extensions for application-specific processor cores are explored. For complex applications, this design space exploration is difficult and requires in-depth analysis of the application and its implementation alternatives. Tools are required which aid the designer in the design, optimization, and scheduling of hardware and software. We present a profiling tool for fast and accurate performance, power, and memory access analysis of embedded systems. This paper shows how the tool can be applied for an efficient hardware/software co-exploration within the design flow of processor-centric architectures. This concept has been proven in the design of a mixed hardware/software system with multiple processing units for video decoding.
A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system (1992)

We report the isolation of a novel human POU domain encoding gene named RDC-1. The POU domain of the RDC-1 encoded protein is highly related to the POU domain potentially encoded by the rat brain-3 sequence and to that of the Drosophila I-POU protein; outside of the POU region, RDC-1 is unrelated to any previously characterized protein. The RDC-1 gene is expressed almost exclusively in normal tissues and transformed cells of neural origin. In the developing mouse and human fetus, RDC-1 is expressed in a spatially and temporally restricted pattern that suggests a critical role in the differentiation of neuronal tissues. In addition, RDC-1 is expressed in a unique subset of tumors of the peripheral nervous system including neuroepitheliomas and Ewing's sarcomas but not neuroblastomas. Based on its unique structural characteristics and expression pattern, we discuss potential functions for the RDC-1 protein.
Influence of monosialoganglioside inner ester on neurologic recovery after global cerebral ischemia in monkeys. (1989)

We assessed the consequences of transitory global cerebral ischemia and the influence of monosialoganglioside inner ester (AGF 2) treatment on neurologic outcome, cerebral blood flow, and cerebral metabolic rate in monkeys over 48 hours. Global cerebral ischemia was produced by a cervical tourniquet and a lowering of blood pressure to 6.65 kPa; recirculation followed after 30 minutes. AGF 2 (30 mg/kg) was administered intravenously immediately after initiation of recirculation and intramuscularly twice a day for 48 hours. Our results show that treatment with AGF 2 significantly accelerated the rate of neurologic recovery. Improvement was evident 5 hours after ischemia; full neurologic recovery was observed in half of the monkeys 48 hours after ischemia. This recovery was associated with a less severe reduction in cerebral blood flow without a concomitant increase in the cerebral metabolic rate.
Space-optimal heavy hitters with strong error bounds (2009)

The problem of finding heavy hitters and approximating the frequencies of items is at the heart of many problems in data stream analysis. It has been observed that several proposed solutions to this problem can outperform their worst-case guarantees on real data. This leads to the question of whether some stronger bounds can be guaranteed. We answer this in the positive by showing that a class of "counter-based algorithms" (including the popular and very space-efficient FREQUENT and SPACESAVING algorithms) provide much stronger approximation guarantees than previously known. Specifically, we show that errors in the approximation of individual elements do not depend on the frequencies of the most frequent elements, but only on the frequency of the remaining "tail." This shows that counter-based methods are the most space-efficient (in fact, space-optimal) algorithms having this strong error bound.
Single-stage Flyback converter for led driver with inductor voltage detection power factor correction (2010)

A constant current output Flyback converter with power factor correction used for LED driving is presented in this paper. The inductor voltage detection method is applied and acquired the inductor voltage to generate the control signal. Based on this design principle, the inner loop of input current shaping is eliminating, the input voltage sensing and multiplier are also not necessary. The simulation and experimental results are provided to demonstrate the effectiveness of the control scheme based on the lab prototype boards. The output load condition is set from full load to light load, and the results show that the system drives the LEDs with high power factor.
Generalized Epilepsy with Febrile Seizures plus and Severe Myoclonic Epilepsy in Infancy: a case report of two Italian families (2001)

"Generalized epilepsy with febrile seizures plus" (GEFS+) syndrome has been recently described. This term defines a heterogeneous group of generalized epilepsies observed in several members of large pedigree studies. The syndrome spectrum has been widened by including others forms of generalized epilepsy. We report two Italian families in which the fathers showed febrile seizure plus (FS+), and two sons had severe myoclonic epilepsy of infancy (SMEI). The clinical setting of each epileptic member of the family will be discussed, focusing on the relationship with the GEFS+ group, confirming its wide clinical spectrum. In fact, GEFS+ is different from most other epilepsy syndromes as it is defined not by a set of associated symptoms but by the genetic transmission of a predisposition to febrile convulsions and other seizures, with a variable expression in several members of the same pedigree, perhaps due to ionic channel dysfunction. SMEI could represent the most severe end of the spectrum.
Measurement of Length Shifts down to 10^−3 Å with a Two-Mode Laser (1970)

The frequency of one axial mode of a two-mode He-Ne laser is tuned by mirror displacement independently from the other mode if a third mirror is added to the usual two laser mirrors. The frequency shift is proportional to the mirror displacement and can be detected with high sensitivity by observing the beat frequency with the other axial mode. The sensitivity of such a two-mode laser with a coupled resonator for measurements of small length shifts has been tested.
Reversal by Hyaluronidase of Adhesion-Dependent Multicellular Drug Resistance in Mammary Carcinoma Cells (1996)

Other tumor-specific "anti-adhesives" should be explored that can be effective chemosensitizers when used in combination with cell cycle-specific drugs for the treatment of small, solid tumors.
First record of Anopheles stephensi in Sri Lanka: a potential challenge for prevention of malaria reintroduction (2017)

Sri Lanka was certified as malaria-free by the WHO in September 2016, however, this new finding may pose a serious challenge to the efforts of the Ministry of Health to prevent the re-introduction of malaria transmission in the country, considering the role that An. stephensi could play in urban and high vulnerability areas of Sri Lanka.
Identification by differential display of annexin-VI, a gene differentially expressed during melanoma progression. (1996)

To identify genes involved in the melanocyte to malignant melanoma conversion, we have applied differential display to the comparison of syngeneic murine B16F10 (metastatic melanoma) and Melan-a-immortalized melanocyte cell lines. Approximately 7000 bands were analyzed, revealing approximately 80 to be differentially displayed. Reverse Northern blotting and subsequent Northern blotting confirmed the reproducible differential expression of four transcripts. Three B16F10-specific bands encode novel genes or partially sequenced cDNAs of unknown function. One Melan-a-specific band was found to be identical to the 3' end region of the mouse Annexin VI mRNA and shown to have a reduced message expression in B16F10 relative to Melan-a. Differential expression was confirmed at the protein level with Western blotting using a rabbit polyclonal antiserum. Immunohistochemistry of human melanoma specimens with this antiserum revealed a decrease or loss of Annexin VI expression as melanomas progressed from a benign to a more malignant phenotype. Our results provide further evidence for a potential role of Annexin VI in tumor suppression.
Optimal scheduling of interleukin-12 and fractionated radiation therapy in the murine lewis lung carcinoma (1998)

Interleukin-12 (IL-12), a naturally occurring cytokine, has demonstrated antitumor activity in several murine solid tumors. The Lewis lung carcinoma was used to study the most effective scheduling of recombinant murine interleukin-12 (rmIL-12) administration with fractionated radiation therapy. The effect of the schedule of rmIL-12 administration alone or along with a 1- or 2-week fractionated radiation therapy regimen was examined. Beginning rmIL-12 prior to or at the same time as radiation therapy and extending rmIL-12 through the radiation regimen and beyond produced the longest tumor growth delays. Those treatment regimens which were most effective against the primary tumor were also most effective in decreasing the number of lung metastases on day 20. To further assess the immunotherapeutic effects from rmIL-12 administration, the efficacy of rmIL-12 with fractionated radiation therapy delivered to a right hind-limb tumor was measured as tumor growth delay in an unirradiated left hind-limb tumor. There was some difference in the tumor growth delay between the unirradiated tumor in the animals bearing an irradiated tumor in the contralateral leg, and the tumors in animals receiving rmIL-12 only. Recombinant murine granulocyte-macrophage-colony stimulating factor (rmGM-CSF) was also an antitumor agent active against the Lewis lung carcinoma and produced an additive effect in combination with fractionated radiation therapy in this tumor. rmIL-12 was a radiation sensitizer in the Lewis lung carcinoma. When rmIL-12 (45-microg/kg) and rmGM-CSF (45 microg/kg) were administered together with fractionated radiation therapy, a marked increase in tumor growth delay resulted. This treatment combination also nearly ablated lung metastases on day 20 in these animals. These results may serve as a useful guide in developing clinical protocols, including rmIL-12 and fractionated radiation therapy.
Motor Neuron Degeneration Induced by Excitotoxin Agonists Has Features in Common with those Seen in the SOD-1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (1996)

A superoxide dismutase 1 (SOD-1)genetic defect has been identified in familial amyotrophic lateral sclerosis (ALS) and motor neuron degeneration has been described in SOD-1 transgenic mice. Because an excitotoxic mechanism has been implicated in ALS, we undertook studies to provide a description of excitotoxic degeneration of spinal motor neurons for comparison with the degenerative process observed in SOD-1 transgenic mice. Excitotoxin agonists selective for each of the three major types of inotropic glutamate receptors were applied directly onto the lumbar spinal cord of 21-day old rats following posterior laminectomy. N-methyl-D-aspartate (NMDA) preferentially affected dorsal horn neurons, whereas the non-NMDA agonist, kainic acid, preferentially affected motor neurons. Cytopathological changes in motor neurons closely resembled those described in SOD-1 mice. These changes consist of massively swollen dendritic processes in the presence of well-preserved presynaptic axon terminals; cell bodies of motor neurons filled with vacuoles that originate both from endoplasmic reticulum and mitochondria; pleomorphic changes in mitochondria; axons of motor neuron becoming swollen proximally with accumulation of vacuoles, organelles, filaments, and degeneration products in the swollen segment. The observed changes in motor axons resemble changes described in the spinal cord of ALS patients. These findings are consistent with the proposal that motor neuron degeneration in ALS may be mediated by an excitotoxic process involving hyperactivation with non-NMDA glutamate receptors.
DNA Synthesis and Repair Genes <i>RRM1</i> and <i>ERCC1</i> in Lung Cancer (2007)

RRM1 and ERCC1 are determinants of survival after surgical treatment of early-stage, non-small-cell lung cancer.
Performance Optimization of Industrial Refrigeration Systems (1999)

Industrial refrigeration systems can be found in applications ranging from ice making to food processing and preservation to industrial chemical processes. These systems typically consist of many different components, each component may be produced by a different manufacturer. The operational data provided by the different manufacturers for each component is used by system designers to specify installation and operational procedures of the system. Often times, the optimum control of an individual piece of equipment results in sub-optimal system performance due to unforeseen interactions between the different system components. It is important to identify and monitor key parameters of the system, such as power consumption and refrigeration effect, in order to optimize the performance. The efforts of this research focused on modeling an operating, ammonia vapor compression, refrigeration system serving a two-temperature food storage and distribution facility located near Milwaukee, WI. This system utilized a combination of both single-screw and reciprocating compressors operating under single-stage
Propagator and Slater sum in one-body potential theory (2009)

For a one-body potential V(r) generating eigenfunctions ψ i (r) and corresponding eigenvalues ∈ i , the Feynman propagator K(r,r',t) is simply related to the canonical density matrix c(r,r',β) by β → it. The diagonal element S(r,r,β) of C is the so-called Slater sum of statistical mechanics. Differential equations for the Slater sum are first briefly reviewed, a quite general equation being available for a one-dimensional potential V(x). This equation can be solved for a sech 2 potential, and some physical properties of interest such as the local density of states are derived by way of illustration. Then, the Coulomb potential -Ze 2 /r is next considered, and it is shown that what is essentially the inverse Laplace transform of S(r,β)/β can be calculated for an arbitrary number of closed shells. Blinder has earlier determined the Feynman propagator in terms of Whittaker functions and contact is here established with his work. The currently topical case of Fermion vapours which are harmonically confined is then treated, for both two and three dimensions. Finally, in an Appendix, a perturbation series for the Slater sum is briefly summarized, to all orders in the one-body potential V(r). The corresponding kinetic energy is thereby accessible.
Novel high voltage transistor fabricated using the <i>i</i> <i>n</i> <i>s</i> <i>i</i> <i>t</i> <i>u</i> junctions in a Si-TaSi2 eutectic composite (1988)

Transistor action has been observed for the first time in a Si-TaSi2 eutectic composite. These devices, utilizing the in situ cylindrical Schottky junctions between the Si matrix and the TaSi2 rod phase, have characteristics typical of a metal-semiconductor field-effect transistor (MESFET). However, unlike a conventional planar device like a MESFET, eutectic transistors are resistant to avalanche breakdown. A device is demonstrated that blocks 600 V, a value that is three times larger than would be expected for a planar device of the same carrier concentration.
Synchronous Demodulator for Autonomous Sensors (2007)

In this paper, a novel differential synchronous demodulator is presented that uses the on-off switching characteristic of the power supply in autonomous systems as the control signal for demodulation. The proposed circuit, which uses only an op amp and a double-pole double-throw switch, can be useful in sensor nodes for sensor networks or distributed data-acquisition systems involving ac sensors or impedance measurements. Three prototype demodulators have been implemented using op amps with different power-bandwidth characteristics, and their common-mode rejection ratio (CMRR), nonlinearity, and initial transient were characterized. The working of the circuit when supplied by a piezoelectric energy converter is also verified.
Efficiency of a programmed −1 ribosomal frameshift in the different subtypes of the human immunodeficiency virus type 1 group M (2003)

The synthesis of the Gag-Pol polyprotein, the precursor of the enzymes of the human immunodeficiency virus type 1 (HIV-1), requires a programmed -1 ribosomal frameshift. This frameshift has been investigated so far only for subtype B of HIV-1 group M. In this subtype, the frameshift stimulatory signal was found to be a two-stem helix, in which a three-purine bulge interrupts the two stems. In this study, using a luciferase reporter system, we compare, for the first time, the frameshift efficiency of all the subtypes of group M. Mutants of subtype B, including a natural variant were also investigated. Our results with mutants of subtype B confirm that the bulge and the lower stem of the frameshift stimulatory signal contribute to the frameshift in addition to the upper stem-loop considered previously as the sole participant. Our results also show that the frameshift stimulatory signal of all of the other subtypes of group M can be folded into the same structure as in subtype B, despite sequence variations. Moreover, the frameshift efficiency of these subtypes, when assessed in cultured cells, falls within a narrow window (the maximal deviation from the mean value calculated from the experimental values of all the subtypes being approximately 35%), although the predicted thermodynamic stability of the frameshift stimulatory signal differs between the subtypes (from -17.2 kcal/mole to -26.2 kcal/mole). The fact that the frameshift efficiencies fall within a narrow range for all of the subtypes of HIV-1 group M stresses the potential of the frameshift event as an antiviral target.
Structure‐Activity Relationship Studies of CNS Agents, Part 31<sup>[1]</sup>: Analogs of MP 3022 with a Different Number of Nitrogen Atoms in the Heteroaromatic Fragment — New 5‐HT<sub>1A</sub> Receptor Ligands (1996)

Two series of new MP 3022 analogs, i.e. 1-(o-methoxyphenyl)-4-n-propylpiperazines (3, 4a, 4b, 6-9, and 12-13) and 2-(n-propyl)-1,2,3,4-tetrahydroisoquinolines (5a, 5b, 11a, and 11b) containing a terminal heteroaromatic system with a different number of nitrogen atoms, were synthesized and their 5-HT1A/5-HT2A and alpha 1 receptor affinity was assayed. The majority of investigated piperazines may be classified as non-selective 5-HT1A/5-HT2A/alpha 1 receptor ligands. Compounds 3, 4a, 4b, 7-9a with the highest affinity for 5-HT1A receptors (Ki = 4-54 nM) were tested in vivo. Their functional activity was differentiated; while 3, 8, and 9a behaved like weak antagonists of postsynaptic 5-HT1A receptors, 4b and 7 may be classified as potential partial 5-HT1A receptors, agonists. Isomer 4a has characteristic features of a potential weak postsynaptic 5-HT1A receptor agonist.
Tumorigenicity of continuous monkey cell lines in in vivo and in vitro systems. (1981)

One of the major considerations on the acceptability of a cell substrate for vaccine production concerns the potential malignancy of those cells. Consequently, we tested a variety of continuous monkey cell lines for tumorigenicity in the immunosuppressed newborn rat and immunosuppressed nonhuman primate and in the chick embryonic skin organ culture. Two positive control tumor cell lines produced progressive tumors in both in vivo systems as well as occasional metastases in the rat. The continuous monkey cell lines did not produce progressively growing tumors in the two in vivo models. However, LLC-MK2, produced occasional microscopic tumors in the nonhuman primate and newborn rat as well as lung metastases in the newborn rat test. In the organ culture assay LLC-MK2 demonstrated proliferative and invasive characteristics similar to the positive tumor lines whereas three other monkey lines were similar to secondary monkey kidney cells.
Expanding Fuel Flexibility Capability in GE’s Aeroderivative Engines (2010)

GE Aviation, through its network of gas turbine OEM’s, has received an increasing number of inquiries and request for quotes for the use of non-standard gas fuels in aero-derivative gas turbine applications. Factors influencing this trend include: increased development of LNG production facilities, increased availability of bio-fuels, lack of availability of standard fuels, reduced acceptance of flaring process gases, and more stringent policies on exhaust emissions. These inquiries and requests propose the use of gas fuels with higher levels of C2+ constituents, or concentrations of hydrogen greater than 5%, or fuels with ever increasing concentrations of high inert gases. Responding to this interest, GE has launched several programs to expand the capability of both SAC (Single Annular Combustor) and Dry Low Emission (DLE) combustion systems. Recent SAC fuel system design enhancements have enabled the LM2500 gas turbine family to operate with either of two, high hydrogen content gases: COG (Coke Oven Gas), a medium BTU fuel (25–35 MWI (Modified Wobbe Index)); or with SYNGAS, a bio-derived, low BTU fuel, (12–14 MWI). To support expanding the DLE capabilities, a series of combustion rig tests and full-scale engine tests have been conducted. Combustion rig testing at one of GE’s Global Research Centers (GRC) has focused on non-standard gas fuels with high concentrations of C2+ constituents. The higher flame speeds of these fuels increase the potential for flashback, and the resulting potential for premature combustor and/or fuel nozzle distress. These tests have allowed GE to more than double the allowable amount of C2+ concentrations in fuel. An LM2500Plus DLE engine recently completed a series of high inert gas fuel testing designed to assess combustor operability and exhaust emissions. This paper intends to summarize the advances GE has made in expanding the range of gas fuels that can be accommodated in the LM2500 and LM6000 product lines.
Silencing of Monocarboxylate Transporters via Small Interfering Ribonucleic Acid Inhibits Glycolysis and Induces Cell Death in Malignant Glioma: An in Vitro Study (2004)

MCT targeting significantly reduced the viability of U-87 MG cells mediated by both apoptosis and necrosis. This indicates that the strategy may be a useful therapeutic avenue for treatment of patients with malignant glioma.