gebhart/patrepeval huggingface dataset:
Butene Oligomerization over Phosphoric Acid: Structural Characterization of Products (2009)

In this study, the butene oligomerate produced over solid (SPA) and liquid phosphoric acid (LPA) was analyzed in detail using GC-MS techniques in conjunction with reported retention time data to identify the alkene isomers in the C6 to C8 fractions produced by the reaction. This information was used to quantify the oligomerate produced over liquid and solid phosphoric catalysts at different temperatures to identify subtle differences between the product distributions. It is hoped that this information will assist in future studies of the oligomerization reaction since several interesting trends that can be linked to previously proposed mechanisms were observed. Group classification of the identified alkenes according to the number of branches identified tetrasubstituted alkenes as compounds that form in large amounts during the reaction, but these are also removed through cracking faster than the other classes at higher temperatures.
High sensitivity detection of Plasmodium species reveals positive correlations between infections of different species, shifts in age distribution and reduced local variation in Papua New Guinea (2009)

The present study demonstrates that application of molecular diagnosis reveals patterns of malaria risk that are significantly different from those obtained by standard LM. Results provide insight relevant to design of malaria control and eradication strategies.
INFORMATION SEEKING PATTERNS OF SELECTED PROFESSIONALS (1980)

No abstract available for this article.
Identification of potential vaccine target antigens by immunoproteomic analysis of a virulent and a non-virulent strain of the fish pathogen Flavobacterium psychrophilum (2007)

Flavobacterium psychrophilum is the etiological agent of bacterial coldwater disease (CWD) and rainbow trout fry syndrome (RTFS). To identify antigens associated with virulence or host immunity, we compared total and immunogenic proteins of cellular and extracellular products (ECP) between a virulent (CSF-259-93) and non-virulent (ATCC 49418) strain of F. psychrophilum. One-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis of total cellular proteins revealed only minor differences between the strains; however, separation of ECP showed that proteins were differentially expressed. Western blot analysis using rainbow trout (Oncorhynchus mykiss) anti-CSF-259-93 sera showed greater reactivity to proteins of the virulent strain, including many > 50 kDa. Further analysis by 2-dimensional electrophoresis (2DE) identified numerous differences between the strains. Western blot analysis combined with 2DE identified several immunogenic proteins that reacted with the antisera and were shared between the 2 strains. However, at least 15 immunogenic proteins appeared to be unique to the virulent strain, while 4 such proteins were identified in the non-virulent strain; 8 proteins unique to the virulent strain and 6 shared proteins were further analyzed for identification by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) analysis. Of these, 3 immunogenic proteins (heat shock proteins HSP 60 and HSP 70) and 2 other proteins (ATP synthase and thermolysin) were conclusively identified. The 2 highly immunogenic heat shock proteins were shown to share extensive homology with heat shock proteins of related bacteria. This approach for antigen identification may provide a basis for targeted vaccine development against CWD and RTFS.
Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. (1992)

Atherosclerosis is a major cause of morbidity and mortality in developed countries. In humans the risk of atherosclerosis is inversely correlated with plasma levels of high density lipoprotein (HDL). As a step in determining whether the experimental reduction of plasma HDL level will increase susceptibility to atherosclerosis, we have used gene targeting in embryonic stem cells to produce mice lacking apolipoprotein A-I, the major protein component of HDL particles. Mice homozygous for the disrupted gene have no plasma apolipoprotein A-I detectable by double immunodiffusion; their total plasma cholesterol and HDL-cholesterol levels after overnight fasting are reduced to about one-third and one-fifth of normal levels, and they are grossly deficient in alpha-migrating HDL particles.
THE FOLLOWING SCHEDULE OF REINFORCEMENT AS A FUNDAMENTAL DETERMINANT OF STEADY STATE CONTRAST IN MULTIPLE SCHEDULES (1981)

Two experiments investigated whether steady-state interactions in multiple schedules depend exclusively on the following schedule of reinforcement. Experiment 1 used a four-component multiple schedule in which two components were associated with the same constant schedule of reinforcement, and where rate of reinforcement was varied in the component that followed one of these. Contrast effects were reliable only in the component that preceded the point of reinforcement variation, although some contrast did occur otherwise. In those instances where contrast other than the following-schedule effect did occur, it was accounted for by the effect of the preceding schedule, an effect for which there were consistent individual differences among subjects, and which varied with component duration. Experiment 2 used a three-component schedule, in which reinforcement rate was varied in the middle component. The results were consistent with Experiment 1, as the following-schedule effect was the only consistent effect that occurred, although an effect of the preceding schedule did occur for some subjects under some conditions, and was especially evident early in training. The conclusion from both experiments is that there is no general effect of relative rate of reinforcement apart from the sum of the effects of the preceding and following schedules, and that the following-schedule effect is the fundamental cause of steady-state interactions.
A novel comparator with hamming code correction for Safety Programmable Logic Controller (2010)

Safety Instrumented Systems (SIS) are automatic systems designed for the purpose of taking an action to avoid an accident or minimize its consequences. Safety Instrumented System relies on many devices that must work as designed at a specific point in a hazard scenario to stop propagation of the hazardous event. Safety Programmable Logic Controller (PLC) plays a more and more important role in the SIS. This paper introduces a quad architecture Safety PLC, which provides complete integration within a single control architecture, where safety and standard control functions reside and work together. A novel comparator is designed with a FPGA chip, which performs hamming code correction and data bus comparison. The safety integrity level and the evaluation approach are introduced.
High confinement in silicon slot waveguides with sharp bends (2006)

Slot waveguides allow for high optical confinement in a planar optical waveguide. Here we show a method for maintaining this high degree of confinement in slot waveguides with sharp bends. This high confinement can be achieved by using an asymmetric slot-based structure, where the mode in the bend remains localized in the slot region. We show that the relative power inside the slot can be as high as 28% for a 1 mum radius bend in an air-clad silicon waveguide.
Human vs. Mouse Nociceptors – Similarities and Differences (2017)

The somatosensory system allows us to detect a diverse range of physical and chemical stimuli including noxious ones, which can initiate protective reflexes to prevent tissue damage. However, the sensation of pain can - under pathological circumstances - outlive its usefulness and perpetrate ongoing suffering. Rodent model systems have been tremendously useful to help understand basic mechanisms of pain perception. Unfortunately, the translation of this knowledge into novel therapies has been challenging. We have investigated similarities and differences of human and mouse peptidergic (TRKA expressing) nociceptors using dual-color fluorescence in situ hybridization of dorsal root ganglia. By comparing the transcripts of a selected group of well-established nociceptive markers, we observed significant differences for some of them. We found co-expression of Trpv1, a key player for sensitization and inflammatory pain, with TrkA in a larger population in humans compared to mice. Similar results could be obtained for Na<sub>v</sub>1.8 and Na<sub>v</sub>1.9, two voltage gated sodium channels implicated in pathological forms of pain. Additionally, co-expression of Ret and TrkA was also found to be more abundant in human neurons. Moreover, the neurofilament heavy polypeptide was detected in all human sensory DRG neurons compared to a more selective expression pattern observed in rodents. To our knowledge, this is the first time that such detailed comparative analysis has been performed and we believe that our findings will direct future experimentation geared to understand the difficulties we face in translating findings from rodent models to humans.
Verbesserung der Sprache mit Hilfe der Velopharyngoplastik bei Patienten mit Lippen-Kiefer-Gaumenspalten (2000)

The velopharyngoplasty is an important method for repair of velopharyngeal insufficiency in patients with cleft palate. In each individual case it is necessary to consider carefully if and when this operation should be performed. An intensive interdisciplinary co-operation of all specialists involved in the treatment is indispensable.
Unmanned Aerial Vehicle (UAV) operated spectral camera system for forest and agriculture applications (2011)

VTT Technical Research Centre of Finland has developed a Fabry-Perot Interferometer (FPI) based hyperspectral imager compatible with the light weight UAV platforms. The concept of the hyperspectral imager has been published in the SPIE Proc. 7474 and 7668. In forest and agriculture applications the recording of multispectral images at a few wavelength bands is in most cases adequate. The possibility to calculate a digital elevation model of the forest area and crop fields provides means to estimate the biomass and perform forest inventory. The full UAS multispectral imaging system will consist of a high resolution false color imager and a FPI based hyperspectral imager which can be used at resolutions from VGA (480 x 640 pixels) up to 5 Mpix at wavelength range 500 - 900 nm at user selectable spectral resolutions in the range 10...40 nm @ FWHM. The resolution is determined by the order at which the Fabry- Perot interferometer is used. The overlap between successive images of the false color camera is 70...80% which makes it possible to calculate the digital elevation model of the target area. The field of view of the false color camera is typically 80 degrees and the ground pixel size at 150 m flying altitude is around 5 cm. The field of view of the hyperspectral imager is presently is 26 x 36 degrees and ground pixel size at 150 m flying altitude is around 3.5 cm. The UAS system has been tried in summer 2011 in Southern Finland for the forest and agricultural areas. During the first test campaigns the false color camera and hyperspectral imager were flown over the target areas at separate flights. The design and calibration of the hyperspectral imager will be shortly explained. The test flight campaigns on forest and crop fields and their preliminary results are also presented in this paper.
Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn’s disease recurrence (2020)

We provide evidence that inflammation-associated mitochondrial dysfunction in the intestinal epithelium triggers a metabolic imbalance, causing reduced stemness and acquisition of a dysfunctional PC phenotype. Blocking glycolysis might be a novel drug target to antagonise PC dysfunction in the pathogenesis of CD.
Animal Models: Live and in Color (2003)

Fusion of imaging technology and molecular techniques is revealing biological changes in living animals. In cancer research, this is leading to new ways of studying tumors, as well as novel diagnostics and potential therapies
Factors Leading to Sales Force Automation Use: A Longitudinal Analysis (2002)

Motivating the sales force to adopt and use sales force automation (SFA) technology remains an issue. If salespeople are not committed to the selling organization's technology strategies, customer alliances are hindered.Survey data were collected from a national sales force before and after the introduction of an SFA application. The results of this study indicate that salesperson attitudes (Perceived Usefulness, Attitude Toward the New System, and Compatibility) have an impact on intention to use new SFA systems prior to implementation. However, Personal Innovativeness, Attitude Toward the New System, and Facilitating Conditions have more of an effect on infusion of new SFA systems.
Synthesis and Cleavage- Secretion of Enzymatically Active Rabbit Angiotensin-converting Enzyme in Pichia pastoris (1996)

Many biologically important ectoproteins that are anchored in the plasma membrane via a hydrophobic domain undergo a proteolytic cleavage process, which releases the ectodomain to the extracellular milieu in a regulated fashion. Angiotensin-converting enzyme (ACE) is one such protein that is secreted from human and mouse cells by its cleavage at one of two alternative sites in the ectodomain. Here, we report similar cleavage-secretion of ACE in the yeast Pichia pastoris. The cleavage site used in yeasts was identical to one of the two sites used in mouse cells. Moreover, as in mammalian cells, ACE secretion in yeast was inhibited by compound 3, a potent inhibitor of the metzincin family of metalloproteases. ACE proteins cleavage-secreted from yeast and from mammalian cells had identical enzymatic properties. These results demonstrate the existence of a secretase activity in yeast whose properties closely resemble those of the mammalian ACE secretase.
Uncertainty Quantification of Channelized Reservoir Using Ensemble Smoother with Selective Measurement Data (2014)

Ensemble smoother (ES) assimilates all available dynamic data without iterations as global update. Therefore, ES is much faster than ensemble Kalman filter (EnKF), which uses recursive updates. Iterative concepts are introduced for ES to increase accuracy of history matching. However, they lose advantages of simulation time and cost over EnKF. We propose ES with selective use of observation data in assimilation to improve history matching results and to keep simulation time short. Three methods, EnKF with all data, ES with all data, and the proposed, are applied to 2D synthetic channelized reservoirs with a nine spot waterflooding. Ensemble-based methods interpret the reason of reduced oil production rate after water breakthrough as low permeability. In this research, we suggest selective measurement data to manage misinterpretable data for the ensemble-based methods. As a logical choice, oil production rate before water breakthrough and water cut after water breakthrough are used for assimilation. EnKF with all data cannot predict true performances of oil and water productions on each well. ES with all data shows severe overshooting and filter divergence problems, which are two typical problems in the ensemble-based methods. However, the proposed method overcomes the two problems and shows good history matching results. It provides reliable uncertainty quantification of reservoir performances for both each well production and field total productions. Simulation cost of the proposed method is about 2.2% of that of EnKF, which uses 45 times update. It has clear advantage over EnKF or iterative ES methods.
Aerosol pollution from internal combustion engines (1968)

Abstract Aerosols have one property that distinguishes them sharply from most other pollutants of the atmosphere. They are easily seen and recognized as pollutants. The first smoke abatement law in the United Kingdom was adopted by proclamation in 1306 during the reign of Edward I, and in 1307 a violator of the prohibition was condemned and executed (Rogers & Edelman 1962). Even from the early days of internal combustion engines the emission of smoke, ‘vapour’ and oily substances has been prohibited. The Motor Vehicles (Construction and Use) Regulations 1966 presently govern emissions from motor vehicles in the United Kingdom. (These regulations are given authority by the Road Traffic Act 1930). For example, appropriate parts of the regulations stipulate, first in relation to construction, that every motor vehicle must be so constructed that it does not emit any avoidable ‘smoke or visible vapour’; and secondly in relation to use, that no vehicle may be used on the road if it emits any ‘smoke, visible vapours, grit, sparks, ashes, cinders or oily substances’ if the emission causes or is likely to cause ‘damage to any property or injury to any person’ actually on, or expected to be on, the road, or is likely to cause danger to any such person.
Exploration of Schedule Space by Random Walk (2009)

Scheduling, an important step in high-level synthesis, is essentially a searching process in the solution space. Due to the vastness of the solution space and the complexity of the imposed constraints, it is usually difficult to explore the solution space efficiently. In this paper, we present a random walk based perturbation method to explore the schedule space. The method works by limiting the search within a specifically defined sub-solution space (SSS), where schedules in the SSS can be found in polynomial time. Then, the SSS is repeatedly perturbed by using an N-dimension random walk so that better schedules can be searched in the new SSS. To improve the search efficiency, a guided perturbation strategy is presented that leads the random walk toward promising directions. Experiments on well-known benchmarks show that by controlling the number of perturbations, our method conveniently makes tradeoff between schedule quality and runtime. In reasonable runtime, the proposed method finds schedules of better quality than existing methods.
Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against <i>Trypanosoma brucei</i> (2015)

Marine natural products are an important source of lead compounds against many pathogenic targets. Herein, we report the discovery of lobosamides A-C from a marine actinobacterium, Micromonospora sp., representing three new members of a small but growing family of bacterially produced polyene macrolactams. The lobosamides display growth inhibitory activity against the protozoan parasite Trypanosoma brucei (lobosamide A IC50 = 0.8 μM), the causative agent of human African trypanosomiasis (HAT). The biosynthetic gene cluster of the lobosamides was sequenced and suggests a conserved cluster organization among the 26-membered macrolactams. While determination of the relative and absolute configurations of many members of this family is lacking, the absolute configurations of the lobosamides were deduced using a combination of chemical modification, detailed spectroscopic analysis, and bioinformatics. We implemented a "molecules-to-genes-to-molecules" approach to determine the prevalence of similar clusters in other bacteria, which led to the discovery of two additional macrolactams, mirilactams A and B from Actinosynnema mirum. These additional analogs have allowed us to identify specific structure-activity relationships that contribute to the antitrypanosomal activity of this class. This approach illustrates the power of combining chemical analysis and genomics in the discovery and characterization of natural products as new lead compounds for neglected disease targets.
Reducing Glucokinase Activity to Enhance Insulin Secretion: A Counterintuitive Theory to Preserve Cellular Function and Glucose Homeostasis (2020)

Pancreatic beta-cells are the only cells in the body that can synthesize and secrete insulin. Through the process of glucose-stimulated insulin secretion, beta-cells release insulin into circulation, stimulating GLUT4-dependent glucose uptake into peripheral tissue. Insulin is normally secreted in pulses that promote signaling at the liver. Long before type 2 diabetes is diagnosed, beta-cells become oversensitive to glucose, causing impaired pulsatility and overstimulation in fasting levels of glucose. The resulting hypersecretion of insulin can cause poor insulin signaling and clearance at the liver, leading to hyperinsulinemia and insulin resistance. Continued overactivity can eventually lead to beta-cell exhaustion and failure at which point type 2 diabetes begins. To prevent or reverse the negative effects of overstimulation, beta-cell activity can be reduced. Clinical studies have revealed the potential of beta-cell rest to reverse new cases of diabetes, but treatments lack durable benefits. In this perspective, we propose an intervention that reduces overactive glucokinase activity in the beta-cell. Glucokinase is known as the glucose sensor of the beta-cell due to its high control over insulin secretion. Therefore, glycolytic overactivity may be responsible for hyperinsulinemia early in the disease and can be reduced to restore normal stimulus-secretion coupling. We have previously reported that reducing glucokinase activity in prediabetic mouse islets can restore pulsatility and enhance insulin secretion. Building on this counterintuitive finding, we review the importance of pulsatile insulin secretion and highlight how normalizing glucose sensing in the beta cell during prediabetic hyperinsulinemia may restore pulsatility and improve glucose homeostasis.
Environmentally Responsible Aviation N plus 2 Advanced Vehicle Study (2013)

This is the Northrop Grumman final report for the Environmentally Responsible Aviation (ERA) N+2 Advanced Vehicle Study performed for the National Aeronautics and Space Administration (NASA). Northrop Grumman developed advanced vehicle concepts and associated enabling technologies with a high potential for simultaneously achieving significant reductions in emissions, airport area noise, and fuel consumption for transport aircraft entering service in 2025. A Preferred System Concept (PSC) conceptual design has been completed showing a 42% reduction in fuel burn compared to 1998 technology, and noise 75dB below Stage 4 for a 224- passenger, 8,000 nm cruise transport aircraft. Roadmaps have been developed for the necessary technology maturation to support the PSC. A conceptual design for a 55%-scale demonstrator aircraft to reduce development risk for the PSC has been completed.
Learning to Recover 3D Scene Shape from a Single Image (2021)

Despite significant progress in monocular depth estimation in the wild, recent state-of-the-art methods cannot be used to recover accurate 3D scene shape due to an unknown depth shift induced by shift-invariant reconstruction losses used in mixed-data depth prediction training, and possible unknown camera focal length. We investigate this problem in detail, and propose a two-stage framework that first predicts depth up to an unknown scale and shift from a single monocular image, and then use 3D point cloud encoders to predict the missing depth shift and focal length that allow us to recover a realistic 3D scene shape. In addition, we propose an image-level normalized regression loss and a normal-based geometry loss to enhance depth prediction models trained on mixed datasets. We test our depth model on nine unseen datasets and achieve state-of-the-art performance on zero-shot dataset generalization. Code is available at: https://git.io/Depth
The blackhole in chemical education (1983)

Citizens of the near future will have different needs from those of twenty or thirty years ago; thus they will need to be educated differently. These authors argue that students around the world will need to be aware of the how, what, and why of chemistry - both the positive and negative aspects.