gebhart/patrepeval huggingface dataset:
H‐2D<sup>b</sup> gene transfer into highly metastatic D122 cells results in tumor rejection in allogeneic recipients, but does not affect metastasis in syngeneic recipients. Implications for mechanisms of allorejection (1992)

Highly metastatic, weakly immunogenic Lewis lung carcinoma clones express very low levels of H-2Kb and moderate levels of H-2Db class-I major histocompatibility complex antigens. These cells metastasize spontaneously in mice with C57BL/6 genetic background possessing the H-2Db locus, and grow as local tumors across allogeneic barriers. Transfection of the H-2Db genes into the highly metastatic clone D122 did not alter the growth or metastatic capacity of these cells in syngeneic mice. However, these cells were rejected in allogeneic mice. Transfection of the H-2Kd or H-2Kk genes into D122 elicited a CTL population that cross-reacted with cells bearing native H-2Db antigens. These data suggest that overlapping allo-CTL populations are induced by a native alloantigen and by alloantigen peptides presented through self class-I molecules.
Integrating discrete and continuous phenomena models into practical advanced user interface specifications (2002)

Most current user interface specification languages and toolkits are based on serial, discrete, token exchange paradigms that perform an acceptable job of implementing traditional WIMP (Window, Icon, Menu, Pointer) interfaces. These tools, however are ill suited to address the needs of emerging interaction studies such as virtual environments and interactive simulations. These interaction styles commonly rely upon full duplex, asynchronous, interrelated dialogues, a blend of continuous and discrete inputs and responses, and implicit commands and probabilistic input events. Some forms of non-WIMP interfaces, particularly interactive simulations, must also contend with real time processing constraints and deadline-based computations. This work proposes a specification paradigm, the SHADOW system, which directly addresses these issues. This system has been demonstrated to allow both the semantic meaning and behavior of all simulation elements to be clearly defined in a reusable fashion while providing support for good software engineering practices.
Analytical methods for determination of <b><i>trans</i></b> fatty acid content in food (2007)

Abstract Adequate analytical tools are required for labelling food products for trans fatty acid (TFA) contents. The choice of the fatty acid (FA) derivatisation is a crucial step in obtaining good results, in particular with short‐chain and conjugated FA. Several gas chromatographic and infrared spectrophometric methods have been developed for analysing TFA in foods, some of which have been validated as official methods after collaborative studies. Complete analysis of total FA often requires the use of complementary high‐performance liquid chromatography methods. This paper reviews the analytical methods developed for identifying and quantifying TFA in foods and presents the official methods of analysis. Neither of these analytical methods enables a TFA naturally occurring in basic food to be distinguished from a TFA formed during an industrial process.
Ultrasonic Velocity in Some Liquid Fluorocarbons<sup>1</sup> (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUltrasonic Velocity in Some Liquid Fluorocarbons1R. T. Lagemann, W. E. Woolf, J. S. Evans, and N. UnderwoodCite this: J. Am. Chem. Soc. 1948, 70, 9, 2994–2996Publication Date (Print):September 1, 1948Publication History Published online1 May 2002Published inissue 1 September 1948https://pubs.acs.org/doi/10.1021/ja01189a047https://doi.org/10.1021/ja01189a047research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
“Safety and Safety Factors: The impact on heat tracing system designs” (2009)

For many years engineers have relied heavily on the use of electrical heat tracing (EHT) “Safety Factors” to offset design and installation contingencies. The impact of arbitrarily selecting or changing safety factors is often overlooked, but can have a significant impact on the final system.
Active Learning of Regular Expressions for Entity Extraction (2017)

We consider the automatic synthesis of an entity extractor, in the form of a regular expression, from examples of the desired extractions in an unstructured text stream. This is a long-standing problem for which many different approaches have been proposed, which all require the preliminary construction of a large dataset fully annotated by the user. In this paper, we propose an active learning approach aimed at minimizing the user annotation effort: the user annotates only one desired extraction and then merely answers extraction queries generated by the system. During the learning process, the system digs into the input text for selecting the most appropriate extraction query to be submitted to the user in order to improve the current extractor. We construct candidate solutions with genetic programming (GP) and select queries with a form of querying-by-committee, i.e., based on a measure of disagreement within the best candidate solutions. All the components of our system are carefully tailored to the peculiarities of active learning with GP and of entity extraction from unstructured text. We evaluate our proposal in depth, on a number of challenging datasets and based on a realistic estimate of the user effort involved in answering each single query. The results demonstrate high accuracy with significant savings in terms of computational effort, annotated characters, and execution time over a state-of-the-art baseline.
Verification of a six-degree of freedom simulation model for the REMUS autonomous underwater vehicle (2001)

Improving the performance of modular, low-cost autonomous underwater vehicles (AUVs) in such applications as long-range oceanographic survey, autonomous docking, and shallow-water mine countermeasures requires improving the vehicles' maneuvering precision and battery life. These goals can be achieved through the improvement of the vehicle control system. A vehicle dynamics model based on a combination of theory and empirical data would provide an efficient platform for vehicle control system development, and an alternative to the typical trial-and-error method of vehicle control system field tuning. As there exists no standard procedure for vehicle modeling in industry, the simulation of each vehicle system represents a new challenge. Developed by von Alt and associates at the Woods Hole Oceanographic Institute, the REMUS AUV is a small, low-cost platform serving in a range of oceanographic applications. This thesis describes the development and verification of a six degree of freedom, non-linear simulation model for the REMUS vehicle, the first such model for this platform. In this model, the external forces and moments resulting from hydrostatics, hydrodynamic lift and drag, added mass, and the control inputs of the vehicle propeller and fins are all defined in terms of vehicle coefficients. This thesis describes the derivation of these coefficients in detail. The equations determining the coefficients, as well as those describing the vehicle rigid-body dynamics, are left in non-linear form. to better simulate the inherently non-linear behavior of the vehicle. Simulation of the vehicle motion is achieved through numeric integration of the equations of motion. The simulator output is then checked against vehicle dynamics data collected in experiments performed at sea. The simulator is shown to accurately model the motion of the vehicle.
Degradation of Misfolded Endoplasmic Reticulum Glycoproteins in <i>Saccharomyces cerevisiae</i> Is Determined by a Specific Oligosaccharide Structure (1998)

In Saccharomyces cerevisiae, transfer of N-linked oligosaccharides is immediately followed by trimming of ER-localized glycosidases. We analyzed the influence of specific oligosaccharide structures for degradation of misfolded carboxypeptidase Y (CPY). By studying the trimming reactions in vivo, we found that removal of the terminal alpha1,2 glucose and the first alpha1,3 glucose by glucosidase I and glucosidase II respectively, occurred rapidly, whereas mannose cleavage by mannosidase I was slow. Transport and maturation of correctly folded CPY was not dependent on oligosaccharide structure. However, degradation of misfolded CPY was dependent on specific trimming steps. Degradation of misfolded CPY with N-linked oligosaccharides containing glucose residues was less efficient compared with misfolded CPY bearing the correctly trimmed Man8GlcNAc2 oligosaccharide. Reduced rate of degradation was mainly observed for misfolded CPY bearing Man6GlcNAc2, Man7GlcNAc2 and Man9GlcNAc2 oligosaccharides, whereas Man8GlcNAc2 and, to a lesser extent, Man5GlcNAc2 oligosaccharides supported degradation. These results suggest a role for the Man8GlcNAc2 oligosaccharide in the degradation process. They may indicate the presence of a Man8GlcNAc2-binding lectin involved in targeting of misfolded glycoproteins to degradation in S. cerevisiae.
Control of p53 multimerization by Ubc13 is JNK-regulated (2009)

The p53 tumor suppressor protein is a key regulator of cellular proliferation and survival whose function is tightly regulated at the levels of transcription and protein stability. Here, we unveil the fine control of p53 on translationally active polysomes. We have previously reported that Ubc13, an E2 ubiquitin-conjugating enzyme, directly regulates p53 localization and transcriptional activity. We now demonstrate that the association of p53 and Ubc13 on polysomes requires ongoing translation and results in p53 ubiquitination that interferes with its tetramerization. JNK phosphorylation of p53 at Threonine 81 occurring on polysomes is required for the dissociation of Ubc13 from p53, leading to p53 multimerization and transcriptional activation. Inhibition of JNK activity or expression of a nonphosphorylatable mutant of p53 maintains an Ubc13-p53 complex that inhibits p53 multimerization. Our findings reveal a layer in the regulation of p53 multimerization that requires the concerted action of JNK and Ubc13 on polysome-bound p53.
Heterogeneous distribution and transmembrane signaling properties of lymphocyte function-associated antigen (LFA-1) in human lymphocyte subsets. (1989)

The role of LFA-1, a member of the integrin supergene family, in intercellular adhesion, including lymphocyte-endothelial cell (EC) binding, has been established. We now demonstrate that differences in LFA-1 cell surface density are responsible for the variable adhesion efficiency of lymphocyte subsets to EC. Electrophoretic analysis revealed multiple glycosylated isoforms of both alpha and beta subunits, largely as a result of different degrees of sialylation, with variable expression among different lymphocyte subsets. Neuraminidase digestion before EC adhesion increased the binding efficiency of all lymphocyte subsets, although the relative increase in each subset was proportional to the initial LFA-1 sialic acid content. LFA-1 cross-linking resulted in phosphoinositide hydrolysis and a rise in [Ca2+]i when using anti-alpha but not anti-beta subunit antibodies. These findings indicate that the density of LFA-1 on lymphocyte subsets controls their adhesive properties, and that the LFA-1 alpha subunit has transmembrane signaling properties that may result in activation events after interaction with its natural ligands.
New developments of 3-level PWM strategies (1989)

info:eu-repo/semantics/published
Restless Legs Syndrome and Attention-Deficit/Hyperactivity Disorder: a Review of the Literature (2005)

Although still limited, evidence from clinical studies demonstrates an association between RLS and ADHD or ADHD symptoms. Further clinical studies using standard criteria and procedures are needed to better estimate the degree of association. Epidemiologic studies are required to assess the relationship between ADHD and RLS symptoms in nonclinical samples. Further investigations should address the mechanisms underlying the relationship between RLS and ADHD. Several dopaminergic agents seem to be promising treatment for RLS associated with ADHD symptoms. To date, however, the absence of randomized and blinded controlled studies does not allow evidence-based recommendations.
<title>Multiple-pair upconversion in Er3+-doped crystals of CsMgCl3, CsMgBr3, and CsCdBr3</title> (1993)

Intense visible to uv up-conversion emission is observed in Er<SUP>3+</SUP> doped crystals of CsMgCl<SUB>3</SUB>, CsMgBr<SUB>3</SUB> and CsCdBr<SUB>3</SUB> when the <SUP>4</SUP>S<SUB>3/2</SUB> (E), <SUP>2</SUP>H<SUB>11/2</SUB> (F) and <SUP>4</SUP>F<SUB>7/2</SUB> (G) states of Er<SUP>3+</SUP> are pumped. The host crystals are of CsNiCl<SUB>3</SUB> type which exhibit a linear chain structure. These hosts incorporate trivalent rare earth ions such as Er<SUP>3+</SUP> to form a M<SUP>3+</SUP>-vacancy-M<SUP>3+</SUP> pair center. When both ions in an Er<SUP>3+</SUP>-vacancy-Er<SUP>3+</SUP> center are simultaneously excited an efficient energy transfer occurs between Er<SUP>3+</SUP> ions.
Enhancement of the deposition rate of TiO2 film in radio frequency reactive sputtering (1994)

Titanium oxide thin films were prepared using rf reactive sputtering in which a titanium target was sputtered in a mixture of Ar and reactive O2 gas. The flow modulation of reactive gas was proposed to enhance the deposition rate of the film which is generally low in continuous flow reactive sputtering. The experimental results indicated that the deposition rate could be enhanced maintaining the film stoichiometric ratio of TiO2. The enhancement occurred because the modulated flow appeared to reduce the formation of compounds on the target surface which inhibit sputtering under continuous flow conditions. The effects of the flow modulation were understood by adapting a reactive sputtering theoretical model.
Production of drugs in small particle form / (1981)

This was produced from a copy of a document sent to us for microfilming.While the most advanced technological means to photograph and reproduce this document have been used, the quality is heavily dependent upon the quality of the material submitted.The following explanation of techniques is provided to help you understand markings or notations which may appear on this reproduction.1.T h e sign or "target" for pages apparently lacking from the document photographed is "Missing Page(s)".If it was possible to obtain the missing page(s) or section, they are spliced into the film along with adjacent pages.This may have necessitated cutting through an image and duplicating adjacent pages to assure you of complete continuity.2. When an image on the film is obliterated with a round black mark it is an indication that the film inspector noticed either blurred copy because of movement during exposure, or duplicate copy.Unless we meant to delete copyrighted materials that should not have been filmed, you will find a good image of the page in the adjacent frame.If copyrighted materials were deleted you will find a target note listing the pages in the adjacent frame.3. When a map, drawing or chart, etc., is part of the material being photo graphed the photographer has followed a definite method in "sectioning" the material.It is customary to begin filming at the upper left hand corner of a large sheet and to continue from left to right in equal sections with small overlaps.If necessary, sectioning is continued again-beginning below the first row and continuing on until complete.4.
Electronic control of extraordinary terahertz transmission through subwavelength metal hole arrays (2008)

We describe the electronic control of extraordinary terahertz transmission through subwavelength metal hole arrays fabricated on doped semiconductor substrates. The hybrid metal-semiconductor forms a Schottky diode structure, where the active depletion region modifies the substrate conductivity in real-time by applying an external voltage bias. This enables effective control of the resonance enhanced terahertz transmission. Our proof of principle device achieves an intensity modulation depth of 52% by changing the voltage bias between 0 and 16 volts. Further optimization may result in improvement of device performance and practical applications. This approach can be also translated to the other optical frequency ranges.
The Study of Ink Pigment Dispersion Parameters (2006)

The purpose of this study was to investigate the influence of rotation speed and milling time on the pigment dispersion quality. The information can be used to obtain a standard laboratory condition at which a wide range of pigments may be dispersed to formulate water-based rotogravure inks. The influence of pigment concentration and shear forces on the pigment dispersion were also studied. The procedure consisted of dispersing the pigment using a laboratory Dispermat® SL bead mill at various milling times with two different rotation speeds and measuring the particle size and particle size distribution of the milled samples. The pigment was then dispersed at standard laboratory condition with different pigment concentrations.
Nutraceuticals, Glycemic Health and Type 2 Diabetes (2008)

Preface. Contributors. 1. Nutraceuticals and Diabetes Prevention and Management. James W. Anderson MD and Vijai Pasupuleti, PhD. Part One: Glycemic Health and Type 2 Diabetes. 2. Epidemiology of Type 2 Diabetes. Karen Chapman-Novakofski, PhD. 3. Preventing Type 2 Diabetes Mellitus. Frank Greenway, MD. 4. Glycemic Index and Glycemic Load: Effects on Glucose, Insulin and Lipid Regulation. Julia MW Wong RD, Andrea R Josse MSc, Livia Augustin PhD, Amin Esfahani BSc, Monica S Banach BSc, Cyril WC Kendall PhD, David JA Jenkins MD. 5. Glycemia: Health Implications. L. Raymond Reynolds, MD, FACP, FACE. 6. Glycemic Health, Type 2 Diabetes and Functional Foods. Kaye Foster-Powell, Alan Barclay and Jennie Brand-Miller. PhD. Part Two: Nutraceuticals and Type 2 Diabetes. 7. Dietary Fiber and Associated Phytochemicals in Prevention and Reversal of Diabetes. James W. Anderson, MD. 8. Cinnamon, Glucose and Insulin Sensitivity. Richard A. Anderson, PhD and Anne-Marie Roussel, PhD. 9. Soybean and Soy Component Effects on Obesity and Diabetes. James W. Anderson, MD and Vijai K. Pasupuleti, PhD. 10. Minerals and Insulin Health. Philip Domenico, PhD and James R. Komorowski. 11. Targeting Oxidant Stress as a Strategy for Preventing Vascular Complications of Diabetes and Metabolic. Syndrome. Mark F. McCarty PhD and Toyoshi Inoguchi MD. 12. Ginseng in Type 2 Diabetes Mellitus: A Review of the Evidence in Humans. John L. Sievenpiper, PhD, Alexandra L. Jenkins, RD,. PhD, Anamarie Dascalu, MD, MSc, P. Mark Starvro, PhD. and Vladimir Vuksan, PhD. 13. Traditional Chinese Medicine in the Management and Treatment of the Symptoms of Diabetes. Azadeh Lankarani-Fard, MD and Zhaoping Li, M.D., PhD. 14. Fenugreek and Traditional Antidiabetic Herbs of Indian Origin. Krishnapura Srinivasan, PhD. 15. Nopal ( Opuntia spp.) and Other Traditional Mexican Plants. Rosalia Reynoso-Camacho, PhD and Elvira Gonzalez de Mejia, PhD . 16. Natural Resistant Starch in Glycemic Management: From. Physiological Mechanisms to Consumer Communications. Rhonda S. Witwer, B.S., M.B.A. 17. Proteins, Protein Hydrolysates or Bioactive Peptides in the Management of Type 2 Diabetes. Joris Kloek PhD, Vijai K. Pasupuleti PhD and Luc J.C. Van Loon. 18. Future Trends and Directions. James W. Anderson, MD and Vijai K. Pasupuleti, PhD. Appendix
Studied on the curing reaction of isocyanuric acid with epoxide resin. I. Reaction of isocyanuric acid with phenyl glycidyl ether. (1985)

尿素を加熱することにより生成する一種の1,3,5-トリアジン化合物であるイソシアヌル酸とフェニルグリシジルエーテルとの反応について検討した。2-メチルイミダゾールを触媒として,160～180℃で1時間反応させ,得られた結晶生成物(mp112～114℃)を赤外,核磁気共鳴および質量スペクトルで分析した。この結晶は5-(フェノキシメチル)-2-オキサゾリジノン[2]と推定されたが,念のために結晶を加水分解して2-アミノエタノール化合物として赤外スペクトルで同定を行なった結果,結晶は前に述べた化合物であると判定された。イソシアヌル酸とフェニルグリシジルエーテルとから5-(フェノキシメチル)-2-オキサゾリジノン[2]が生成する反応経路について推定を行なった。
Role-based access control in telecommunication service management—dynamic role creation and management in TINA service environment (1998)

Article Free Access Share on Role-based access control in telecommunication service management—dynamic role creation and management in TINA service environment Author: Takeo Hamada Fujitsu Laboratories of America, 595 Lawrence Expway, Sunnyvale, CA Fujitsu Laboratories of America, 595 Lawrence Expway, Sunnyvale, CAView Profile Authors Info & Claims RBAC '98: Proceedings of the third ACM workshop on Role-based access controlOctober 1998 Pages 105–113https://doi.org/10.1145/286884.286905Online:01 October 1998Publication History 0citation482DownloadsMetricsTotal Citations0Total Downloads482Last 12 Months4Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Bright futures demonstration project: The future in children's support (2006)

Merri Outreach Support Service (MOSS) works with those that are homeless or at risk of homelessness in the Northern and Western metropolitan areas of Melbourne and has been the auspice agency for the Regional Children's Resource Program (RCRP) since it's inception in 2001. The RCRP are funded to provide secondary consultation and training for SAAP workers who need assistance in their work with children. The RCRP workers support agencies to develop child-centred tools and policies, provide agencies with information to support their work with children, and raise the awareness of children's needs within the sector. This resource is aimed at upskilling workers and encouraging them to have confidence when working with children.
Preparation of bone‐like apatite–collagen nanocomposites by a biomimetic process with phosphorylated collagen (2007)

By imitating in vivo bone mineralization, bone-like apatite-collagen nanocomposites were prepared by chemical phosphorylation of collagen and subsequent biomimetic growth of bone-like nanoapatite on collagen nanofibers. Two steps were employed in the composites preparation. First, the collagen was phosphorylated by chemical treatment, which provides the nucleation sites for bone-like apatite mineralization. The subsequent growth of bone-like nanoapatite on the phosphorylated collagen nanofibers was performed in simulated body fluid (SBF). The characterization of the composites showed that the composites were composed of nanoapatite mineralized collagen nanofibers that exhibit similarity to natural bone in composition and crystal morphology.