gebhart/patrepeval huggingface dataset:
Internal ballistics of solid-fuel rockets : military rockets using dry-processed double-base propellant as fuel (1950)

Internal ballistics of solid-fuel rockets: military rockets using dry-processed double-base propellant as fuel , Internal ballistics of solid-fuel rockets: military rockets using dry-processed double-base propella... , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Neurocardiogenic syncope. Diagnosis, mechanisms, and treatment. (1993)

Neurocardiogenic syncope is a common medical problem that can be identified easily by history and the findings of the head-up tilt test. Depressor reflexes from the heart causing sympathetic withdrawal that, in turn, lead to peripheral vasodilatation and hypotension may have an important role in the pathogenesis of neurocardiogenic dysfunction. Once a diagnosis of neurocardiogenic syncope has been made, specific therapeutic strategies can usually prevent recurrent syncope. However, the natural history of neurocardiogenic syncope has not been studied. Double-blind placebo-controlled studies or drug withdrawal trials are needed to assess whether all patients with neurocardiogenic syncope need lifelong therapy.
Sidebar: Transgenic trap crops and rootstocks show potential (2004)

B may offer unique opportunities for pest control in perennial tree and vine crops (Dandekar et al. 2002). Trap crops — plants that an insect pest prefers to the commercial crop — have been tested in a number of agricultural settings, but in most cases have not achieved control levels high enough to completely replace chemical pesticides. Insects are attracted to the trap plant, but they multiply there and can spread to the adjacent crop. A variant on this concept is to incorporate expression of the Bacillus thuringiensis (Bt) insecticidal protein into the trap plant. When the insect feeds on the transgenic trap plant, it dies and the insect population is reduced, thereby protecting the nearby commercial crop. Dry Creek Laboratories of Hughson, Calif., demonstrated this concept with codling moth (Cydia pomonella), a major pest of apples, pears, walnuts and other fruits. The female moth lays eggs on the leaves or fruit, which then hatch into larvae that burrow into the fruits, making them unmarketable. Pesticide sprays and pheromone dis-
Comparative analysis of methods for computing pole angle offsets in magnetic pole wheels using ABS sensor (2013)

Magnetic pole wheels, that are typically used in vehicles to measure speed, have inherent manufacturing intolerance resulting in variable pole length in each pole wheel. Moreover, due their use in harsh and prone to dust environment, magnetic characteristics of each pole change over a period of time. This gives rise to change in pole pitch reported by the ABS sensors. The target here is to accurately measure pole angles by analyzing the ABS sensor signal. This paper describes two methods to achieve optimum pole angle or offset calculation by Synchronous Averaging and Kalman Filter accompanied by a novel Pole Skipping technique to compensate for the speed variations. The computed pole angles can be used to calculate the speed signal more accurately. Besides that, application of pole offset correction will remove the regular pattern from the speed signal data, which prevails in its spectrum suppressing important information related to tire vibrations.
Reliability-Based Sliced Error Correction in Secret Key Agreement from Fading Channel (2010)

We consider information reconciliation in secret key agreement from a fading channel where two legitimate parties utilize channel estimates of their fading channel as correlated random variables to generate a secret key. The information reconciliation is a process of correcting the discrepancies between the legitimate parties' keys by public discussion in the presence of eavesdropper, where the amount of the information revealed in the public discussion is needed to be as little as possible. In this paper, we propose information reconciliation protocols using the reliability values of channel estimates in order to correct errors effectively. The proposed information reconciliation protocols are modified versions of a protocol used in quantum key distribution called sliced error correction using Cascade. Simulation results show that the proposed protocols can correct errors with less the number of disclosed bits and less the number of communications than the conventional sliced error correction using Cascade.
Emotion Recognition through Physiological Signals for Human-Machine Communication (2010)

The ability to recognize emotion is one of the hallmarks of emotion intelligence. This paper proposed to recognize emotion using physiological signals obtained from multiple subjects. IAPS (International Affective Picture System) images were used to elicit target emotions. Five physiological signals: Blood volume pulse (BVP), Electromyography (EMG), Skin Conductance (SC), Skin Temperature (SKT) and Respiration (RESP) were selected to extract 30 features for recognition. Two pattern classification methods, Fisher discriminant and SVM method are used and compared for emotional state classification. The experimental results indicate that the proposed method provides very stable and successful emotional classification performance as 92% over six emotional states. 20 www.intechopen.
Elevated Serum Sialyl Lewis X-i Antigen Levels in Non-Small Cell Lung Cancer with Lung Metastasis (1998)

To evaluate the relationship between serum levels of sialyl Lewis X-i antigen and lung metastasis in patients with non-small cell lung cancer (NSCLC), we measured the serum level of the antigen in 299 patients with untreated locally advanced or metastatic NSCLC. Before treatment, serum levels of sialyl Lewis X-i antigen were significantly higher in patients with lung metastasis than in those without lung metastatis (p = 0.0001). Of 201 patients without lung metastasis at the time of primary diagnosis, 121 patients died between July 1987 and December 1995. Serum levels of sialyl Lewis X-i antigen in 21 patients who developed lung metastasis during the period were significantly higher than those in 100 patients who did not develop lung metastasis (p = 0.0171). Our results suggested that sialyl Lewis X-i antigen might be a good indicator for the presence or development of lung metastasis, and it might provide clinical information about the management of patients with NSCLC.
Complete Genome Sequences of Lytic Bacteriophages of Xanthomonas arboricola pv. juglandis (2016)

Three bacteriophages, f20-Xaj, f29-Xaj, and f30-Xaj, with lytic activity against Xanthomonas arboricola pv. juglandis were isolated from walnut trees (VIII Bío Bío Region, Chile). These lytic bacteriophages have double-stranded DNA (dsDNA) genomes of 43,851 bp, 41,865 bp, and 44,262 bp, respectively. These are the first described bacteriophages with lytic activity against X. arboricola pv. juglandis that can be utilized as biocontrol agents.
CRM collaboration in financial services networks: a multi‐case analysis (2006)

Purpose The aim of this paper is to identify key issues and successful patterns of collaborative customer relationship management (CRM) in financial services networks. Design/methodology/approach The study takes the form of a multi‐case analysis. Findings The paper finds that key issues of CRM in financial services networks are redundant competencies of partnering companies, privacy constraints, CRM process integration, customer information exchange, and CRM systems integration. To address these issues, partnering companies have to agree on clear responsibilities in collaborative processes. Data privacy protection laws require that customer data transfer between partnering companies has the explicit approval of customers. For process integration, companies have to agree on process standards and a joint integration architecture. Web services and internet‐based standards can be used for inter‐organizational systems integration. Data integration requires the development of a joint data model. Either a unique customer identification number or a matching algorithm must be used to consolidate customer data records of partnering companies. Research limitations/implications Because of the limited number of case studies, generalizability is limited. The findings can serve as a starting point for researchers seeking to further explore the topic with quantitative methods. Practical implications The findings can be used by financial services networks to improve their collaborative CRM approaches. Originality/value The importance of collaborative CRM in business networks is likely to increase due to the continuing deconstruction of value chains not only in the financial services industry, but in other industries as well. Nevertheless, the topic has not received much attention in research.
Screening for Diabetic Retinopathy: The wide-angle retinal camera (1993)

Fundus photographs taken by the 45 degrees camera through pharmacologically dilated pupils and read by trained readers perform as well as ophthalmologists for detecting diabetic retinopathy. Physician extenders can effectively perform the photography with minimal training but would require more training to perform adequate eye exams. In this older population, many patients did not obtain adequate nonpharmacological dilation for use of the 45 degrees camera.
Anhydrous cobalt(III) nitrate (1968)

R. J. Fereday, N. Logan and D. Sutton, Chem. Commun. (London), 1968, 271 DOI: 10.1039/C19680000271
Peptide deformylase is a potential target for anti‐<i>Helicobacter pylori</i> drugs: Reverse docking, enzymatic assay, and X‐ray crystallography validation (2006)

Colonization of human stomach by the bacterium Helicobacter pylori is a major causative factor for gastrointestinal illnesses and gastric cancer. However, the discovery of anti-H. pylori agents is a difficult task due to lack of mature protein targets. Therefore, identifying new molecular targets for developing new drugs against H. pylori is obviously necessary. In this study, the in-house potential drug target database (PDTD, http://www.dddc.ac.cn/tarfisdock/) was searched by the reverse docking approach using an active natural product (compound 1) discovered by anti-H. pylori screening as a probe. Homology search revealed that, among the 15 candidates discovered by reverse docking, only diaminopimelate decarboxylase (DC) and peptide deformylase (PDF) have homologous proteins in the genome of H. pylori. Enzymatic assay demonstrated compound 1 and its derivative compound 2 are the potent inhibitors against H. pylori PDF (HpPDF) with IC50 values of 10.8 and 1.25 microM, respectively. X-ray crystal structures of HpPDF and the complexes of HpPDF with 1 and 2 were determined for the first time, indicating that these two inhibitors bind well with HpPDF binding pocket. All these results indicate that HpPDF is a potential target for screening new anti-H. pylori agents. In addition, compounds 1 and 2 were predicted to bind to HpPDF with relatively high selectivity, suggesting they can be used as leads for developing new anti-H. pylori agents. The results demonstrated that our strategy, reverse docking in conjunction with bioassay and structural biology, is effective and can be used as a complementary approach of functional genomics and chemical biology in target identification.
Catalytic Asymmetric Alkylation of Substituted Isoflavanones (2009)

The asymmetric alkylation of isoflavanones (3-aryl-chroman-4-ones) and protected 3-phenyl-2,3-dihydroquinolin-4(1H)-ones catalyzed by a novel cinchonidine-derived phase transfer catalyst E is reported. This functionalization occurs at the unactivated C3 methine to afford novel products that can easily be functionalized to generate more complex fused ring systems. The process accommodates a variety of isoflavanones and activated electrophiles and installs a stereogenic quaternary center in high yield and with good-to-excellent selectivity. Isoflavanones are a privileged class of natural products with a broad spectrum of biological activities including insecticidal, antimicrobial, antibacterial, estrogenic, antitumor, and anti-HIV activity. (1) Isoflavanones are also precursors for more complex natural products such as pterocarpans and rotenones. (1) Given their therapeutic promise, selective strategies to access new classes of isoflavanones and related structures has high value. (2) The functionalization of the C3 position could promote beneficial interactions with biological targets of interest. Specifically, an alkylation at C3 can rapidly access new members of the general class of biologically active homoisoflavanones. (3).
A Single Stage High Power Factor SupplyBased on Integrated Buck Flyback Converter (2013)

In recent years, power converters are used to get high power factor. This paper presents an integrated converter topology for driving HB LEDs which provides high power factor. The integrated buck flyback converter is a single stage, low cost, high power factor AC-DC converter with fast output regulation. The converter is used to provide power factor correction in streetlight application. To obtain high power factor, the buck stage and flyback stage are operated in discontinuous mode. Dimming operation of HB LED is also described. A closed loop is used for enabling the PWM dimming. The simulation studies using MATLAB/Simulink is also presented. Hardware setup of open loop is described.
Intracellular human gamma-interferon triggers an antiviral state in transformed murine L cells. (1987)

Interaction of human gamma-interferon (IFN-gamma) with a cell-surface receptor is known to be essential for the cell to become resistant to viral infection. Here we demonstrate that IFN-gamma, when present inside the cell, is also capable of inducing a permanent antiviral state. Mouse cells transformed with a truncated human cDNA encoding a mature IFN-gamma protein lacking the signal peptide accumulate high levels of intracellular human IFN-gamma. Not only do these cells acquire a permanent resistance to viral infection, they also exhibit all the biochemical characteristics normally observed after exposure to exogenous IFN. The observed loss of species specificity normally associated with IFN-gamma suggests that this restriction is strictly dependent on the interaction of the molecule with the cell-surface receptor.
Use of retinoids in the treatment of psoriasis. (1989)

The limitations of conventional therapy for psoriasis are reviewed, and the pharmacology, pharmacokinetics, clinical efficacy, adverse effects, dosing and therapeutic monitoring of etretinate and other retinoids are described. Traditional treatments for psoriasis include topical application of anthralin and coal tar ointments; systemic therapy with corticosteroids or methotrexate; and systemic or methotrexate; and systemic psoralens combined with exposure to ultraviolet light (PUVA). The topical therapies are beneficial but aesthetically displeasing to patients; the systemic treatments are associated with severe adverse reactions. Etretinate provides another option in the treatment of psoriasis. Etretinate and acitretin, an investigational retinoid, appear to be effective oral therapies for severe variants of psoriasis, especially pustular psoriasis. Retinoids generally do not offer substantial therapeutic advantages over other treatments for chronic-plaque psoriasis. The most common adverse effects of etretinate are cheilitis, alopecia, desquamation of the skin, drying of mucous membranes, and pruritus. Use of low-dose etretinae in combination with other forms of therapy, such as corticosteroids or PUVA, may minimize the frequency of adverse effects. Etretinate is a known teratogen. Its elimination half-life is prolonged to 100-120 days with long-term use. Acitretin, the carboxylic acid derivative of etretinate, has a much shorter elimination half-life than etretinate (50 hours after multiple doses). Its adverse-effect profile is similar to that of etretinate. Etretinate and acitretin appear to be clinically effective for therapy of severe variants of psoriasis. Etretinate should not be used to treat mild psoriasis because of the high incidence of serious adverse effects.
Rosacea-like demodicidosis involving the eyelids. A case report (1967)

A case is presented which illustrates the classical appearance of rosacea-like demodicidosis of the face with an unusual complication of eyelid involvement showing dry, follicular scales and superficial papulopustules in which enormous numbers of<i>Demodex folliculorum</i>were present. Clinical cure and disappearance of the organisms resulted from topical therapy alone, consisting of a compound sulfur ointment (Danish ointment). There was no evidence of irritation of either the eyes or eyelids from this medication.
Enzymatic Synthesis of a Capsinoid by the Acylation of Vanillyl Alcohol with Fatty Acid Derivatives Catalyzed by Lipases (2002)

Capsinoids are a novel group of compounds produced by the Capsicum plant. We synthesized a capsinoid by the lipase-catalyzed esterification of vanillyl alcohol with fatty acid derivatives in an organic solvent. The use of seven out of 17 commercially available lipases, especially Novozym 435, was applicable to the synthesis of vanillyl nonanoate, a model compound of capsinoids. The yield of vanillyl nonanoate under the optimum conditions of 50 mM vanillyl alcohol and 50 mM methyl nonanoate in 500 microl of dioxane, using 20 mg of Novozym 435 and 50 mg of 4 A molecular sieves at 25 degrees C, was 86% in 20 h. Several capsinoid homologues having various acyl chain lengths (C6-C18) were synthesized at 64-86% yields from the corresponding fatty acid methyl ester. The natural capsinoids, capsiate and dihydrocapsiate, were obtained by a 400-fold-scale reaction at these optimum conditions in 60% and 59% isolated yields, respectively.
Neuronal Ganglioside Increases Dependent on the Neuron‐Glia Interaction in Primary Culture (1992)

Dissociated neuronal cells from rat embryonic hemispheres were cultivated on astroglial layers. The increase in ganglioside content of the cocultures was more rapid than that of neuronal cultures seeded on polylysine surfaces for the first 24 h, and the extent of the increase was greater 7 days after inoculation, probably because of interaction between the preformed astroglial layers and the neuronal cells in vitro. The promoted expression of the a-pathway gangliosides, GM1 and GD1a, was recognized by TLC and the increase in GM1 was immunologically ascertained. The incorporation of 3H-labeled N-acetyl-D-mannosamine into GD3 and b-series gangliosides was elevated for the first 24 h. However, cocultures in which there was no contact between neuronal cells and the astroglial sheet showed no appreciable increase in incorporation. Thus, cell surface changes were induced at the membrane glycolipid level in the neuronal cells by contact with astroglial layers. The synthesis and expression of neuronal gangliosides are discussed in relation to the onset of neuron--glia interaction.
Multi-document topic segmentation (2010)

Multiple documents describing the same or closely related sets of events are common and often easy to obtain: for example, consider document clusters on a news aggregator site or multiple reviews of the same product or service. Even though each such document discusses a similar set of topics, they provide alternative views or complimentary information on each of these topics. We argue that revealing hidden relations by jointly segmenting the documents, or, equivalently, predicting links between topically related segments in different documents would help to visualize documents of interest and construct friendlier user interfaces. In this paper, we refer to this problem as multi-document topic segmentation. We propose an unsupervised Bayesian model for the considered problem that models both shared and document-specific topics, and utilizes Dirichlet process priors to determine the effective number of topics. We show that topic segmentation can be inferred efficiently using a simple split-merge sampling algorithm. The resulting method outperforms baseline models on four datasets for multi-document topic segmentation.
Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use (2016)

Dextromethorphan (DM) has been used for more than 50years as an over-the-counter antitussive. Studies have revealed a complex pharmacology of DM with mechanisms beyond blockade of N-methyl-d-aspartate (NMDA) receptors and inhibition of glutamate excitotoxicity, likely contributing to its pharmacological activity and clinical potential. DM is rapidly metabolized to dextrorphan, which has hampered the exploration of DM therapy separate from its metabolites. Coadministration of DM with a low dose of quinidine inhibits DM metabolism, yields greater bioavailability and enables more specific testing of the therapeutic properties of DM apart from its metabolites. The development of the drug combination DM hydrobromide and quinidine sulfate (DM/Q), with subsequent approval by the US Food and Drug Administration for pseudobulbar affect, led to renewed interest in understanding DM pharmacology. This review summarizes the interactions of DM with brain receptors and transporters and also considers its metabolic and pharmacokinetic properties. To assess the potential clinical relevance of these interactions, we provide an analysis comparing DM activity from in vitro functional assays with the estimated free drug DM concentrations in the brain following oral DM/Q administration. The findings suggest that DM/Q likely inhibits serotonin and norepinephrine reuptake and also blocks NMDA receptors with rapid kinetics. Use of DM/Q may also antagonize nicotinic acetylcholine receptors, particularly those composed of α3β4 subunits, and cause agonist activity at sigma-1 receptors.
Polymer‐supported nucleophilic radiolabeling reactions with [<sup>18</sup>F]fluoride and [<sup>11</sup>C]cyanide ion on quaternary ammonium resins (1989)

Peer Reviewed
The essence of three-phase PFC rectifier systems (2011)

In this paper, three-phase PFC rectifier topologies with sinusoidal input currents and controlled output voltage are derived from known single-phase PFC rectifier systems and/or passive three-phase diode rectifiers. The systems are classified into hybrid and fully active PWM boost-type or buck-type rectifiers, and their functionality and basic control concepts are briefly described. This facilitates the understanding of the operating principle of three-phase PFC rectifiers starting from single-phase systems, and organizes and completes the knowledge base with a new hybrid three-phase buck-type PFC rectifier topology denominated as Swiss Rectifier. In addition, analytical formulas for calculating the current stresses on the power semiconductors of selected topologies are provided, and rectifier systems offering a high potential for industrial applications are comparatively evaluated concerning the semiconductor stresses, the loading and volume of the main passive components, and the DM and CM EMI noise level. Finally, core topics of future research on three-phase PFC rectifier systems are discussed, such as the analysis of novel hybrid buck-type PFC rectifier topologies, the direct input current control of buck-type systems, the multi-objective optimization of PFC rectifier systems concerning efficiency and power density, and the investigation of the system performance sensitivity to semiconductor and passive components technology.