gebhart/patrepeval huggingface dataset:
Synthesis and Structural Studies of Cyclotriveratrylene Derivatives (2006)

Abstract Cyclotriveratrylene (CTV) derived host molecules with ethyl, propyl, allyl or propargyl functional groups have been synthesised using standard or solventless reaction methodologies. The known structural and clathrate chemistry of cyclotriveratrylene (CTV) and these analogues has been extended. Crystal structures of the hexa(ethyl), tri(ethyl), tri(propargyl) analogues have been determined, and show either intra-cavity host-guest binding or self-stacking motifs. Two new clathrates of CTV have also been structurally characterised, namely CTV.(DMSO)2.(H2O)2 with intra-cavity complexation of DMSO, and CTV.(EtOH)0.25 which has a γ-phase CTV structure. Keywords: CyclotriveratryleneHost moleculesClathrate complexesCrystal structures Acknowledgements We thank the EPSRC and University of Leeds for financial support.
VISIT: Virtual Intelligent System for Informing Tourists (2012)

Abstract – In recent years ‘smartphone ’ devices are becoming increasingly aware of their surroundings using sensors to detect a user’s current context. Due to this increase in the use of sensors, there is currently a lot of potential for developing context-aware mobile applications. One of the key uses of sensor data in context-aware applications is determining location, as this can greatly improve the potential functionality available to the user. However, there are other types of context that can be determined when developing these applications. For example time, weather and even the person using the device. An activity that can be significantly improved with the introduction of context is mobile tourism. Traditional mobile tourism applications depend heavily on location, and for the most part ignore other types of context. This can lead to the delivery of irrelevant information to the user as there is a lack of adequate content filtering. If the user is inundated with irrelevant or only partially relevant material, this can lead to information overload. Using additional context data can assist these applications in reducing information overload. However, it is important to include an appropriate level of personalisation when performing content filtering to ensure the delivery of key focused information.
Calorimetric Heats of Adsorption and Adsorption Isotherms. 3. Mixtures of CH<sub>4</sub> and C<sub>2</sub>H<sub>6</sub> in Silicalite and Mixtures of CO<sub>2</sub> and C<sub>2</sub>H<sub>6</sub> in NaX (1997)

Individual heats of adsorption and selectivity of mixtures have been measured simultaneously in a calorimeter. After the weakly adsorbed component was preloaded the dosing of both components to the sample cell was adjusted to hold the loading of the weakly adsorbed component constant. Agreement with ideal adsorbed solution theory is quantitative for mixtures of CH4 and C2H6 at low coverage in an adsorbent with a weak electric field (silicalite). Mixtures of quadrupolar (CO2) and nonpolar (C2H6) gases in an adsorbent with a strong electric field (NaX) exhibit strong negative deviations from ideality. The experimental heats of adsorption are larger than those for an ideal solution, in agreement with the results of molecular simulation.
Chemical Synthesis of Dinucleotide Cap Analogs (2013)

This unit describes a reliable, efficient and general method for the synthesis of standard cap analog (mCAP), m(7)G[5']ppp[5']G, and anti-reverse cap analog (ARCA), m(7,3')(O)G[5']ppp[5']G. The synthesis of required intermediate m(7)GDP or m(2)(7,3'O)GDP has been achieved through regioselective methylation of the corresponding diphosphate using dimethyl sulfate under aqueous conditions. Then, the coupling reaction of m(7)GDP or m(2)(7,3'O)GDP with ImGMP using ZnCl(2)/DMF system affords the corresponding cap analog in good yields.
The A-ISDN Proposal to Bridge "Personal Computers" and "ISDN". (1989)

Abstract The present recommendations for data communications on the ISDN seem to have been defined for the connection of dumb-terminals to computerports at 19.2 kbit/s or slower. Personal computers can (and need to) communicate, with each other and with LANs, much faster than dumb-terminals. The A-ISDN proposal is made to make better use of the new ISDN connections, which allow most unchanged installed personal computers to communicate at 90 percent of the 64 kbit/s that digital (telephone) networks will offer for data communications.
Design of an optimal aggregator for vehicle-to-grid regulation service (2010)

Since a possibility for grid-side use of electric-drive vehicles was first claimed, regulation has been proved to be most feasible service by many earlier studies. Moreover, with the emergence of Plug-in HEV, an actual introduction of the regulation service is getting more realistic. To launch the practical service, however, the development of a smart control interface called an aggregator between the grid and the vehicles should be preceded. The main role of the aggregator is, as the name indicates, to synchronize the charge and the discharge operations of multiple vehicles to provide significant amount of power capacity for the regulation service. Consequently, the aggregator has to hold the control of each vehicle. Meanwhile, from the perspective of a vehicle owner, the primary goal of plugging the vehicle into the grid is charging the battery to serve next drive. Since a vehicle that joined the regulation is following the command from the aggregator, it is also the responsibility of the aggregator to perform the desired amount of battery charging. Therefore, the aggregator should have an appropriate strategy to provide regulation service while performing battery charging. In this paper, we assess various aspects of the aggregator, and develop an optimal control strategy for the aggregator regarding a performance measure. Finally, proprieties of the suggested aggregator are verified with simulations.
Watchmen: Scalable Cheat-Resistant Support for Distributed Multi-player Online Games (2013)

Multi-player online games are inherently distributed applications, and a wide range of distributed architectures have been proposed. However, only few successful commercial systems follow such approaches, even given their benefits, due to one main hurdle: the easiness with which cheaters can disrupt the game state computation and dissemination, perform illegal actions, or unduly gain access to sensitive information. The challenge is that any measures used to address cheating must meet the heavy scalability and tight latency requirements of fast paced games. We propose Watchmen, the first distributed scalable protocol designed with cheat detection and prevention in mind that supports fast paced games. It is based on a randomized dynamic proxy scheme for both the dissemination and verification of actions. Furthermore, Watchmen reduces the information exposed to players close to the minimum required to render the game. We build our proof-of-concept prototype on top of Quake III. We show that Watchmen, while scaling to hundreds of players and meeting the tight latency requirements of first person shooter games, is able to significantly reduce opportunities to cheat, even in the presence of collusion.
Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters (2005)

DNA (cytosine-5)-methyltransferase (DNMT) 1 participates in transcriptional repression of genes by methylation-dependent and -independent mechanisms. Here, DNMT1 is shown to bind p53 and colocalize in the nucleus. DNMT1-mediated methylation is stimulated by p53 in vitro. Upon p53 induction, a reporter construct containing the antiapoptotic gene survivin promoter, which contains a natural p53 binding site, was methylated in WT HCT116 cells but not in DNMT1 null or p53 null cells. Endogenous survivin gene repression involves cooperation between DNMT1 and p53 and is relieved by introduction of DNMT1- or p53-specific small inhibitory RNA. DNMT1 null cells did not exhibit a significant repressive effect for p53 responsive survivin and cdc25C gene expression compared with the parental cells. Normal human fibroblasts also exhibited similar DNMT1- and p53-mediated methylation of the survivin promoter, suggesting cooperation between p53 and DNMT1 in gene silencing.
A Proposed Nomenclature for Pulmonary Surfactant-associated Proteins (1988)

"A Proposed Nomenclature for Pulmonary Surfactant-associated Proteins." American Review of Respiratory Disease, 138(4), pp. 990–998
IQGAP1 Interaction with RHO Family Proteins Revisited (2016)

IQ motif-containing GTPase activating protein 1 (IQGAP1) plays a central role in the physical assembly of relevant signaling networks that are responsible for various cellular processes, including cell adhesion, polarity, and transmigration. The RHO family proteins CDC42 and RAC1 have been shown to mainly interact with the GAP-related domain (GRD) of IQGAP1. However, the role of its RASGAP C-terminal (RGCT) and C-terminal domains in the interactions with RHO proteins has remained obscure. Here, we demonstrate that IQGAP1 interactions with RHO proteins underlie a multiple-step binding mechanism: (i) a high affinity, GTP-dependent binding of RGCT to the switch regions of CDC42 or RAC1 and (ii) a very low affinity binding of GRD and a C terminus adjacent to the switch regions. These data were confirmed by phosphomimetic mutation of serine 1443 to glutamate within RGCT, which led to a significant reduction of IQGAP1 affinity for CDC42 and RAC1, clearly disclosing the critical role of RGCT for these interactions. Unlike CDC42, an extremely low affinity was determined for the RAC1-GRD interaction, suggesting that the molecular nature of IQGAP1 interaction with CDC42 partially differs from that of RAC1. Our study provides new insights into the interaction characteristics of IQGAP1 with RHO family proteins and highlights the complementary importance of kinetic and equilibrium analyses. We propose that the ability of IQGAP1 to interact with RHO proteins is based on a multiple-step binding process, which is a prerequisite for the dynamic functions of IQGAP1 as a scaffolding protein and a critical mechanism in temporal regulation and integration of IQGAP1-mediated cellular responses.
Limits of localized heating by electromagnetically excited nanoparticles (2006)

Based on an analysis of the diffusive heat flow equation, we determine limits on the localization of heating of soft materials and biological tissues by electromagnetically excited nanoparticles. For heating by rf magnetic fields or heating by typical continuous wave lasers, the local temperature rise adjacent to magnetic or metallic nanoparticles is negligible. However, heat dissipation for a large number of nanoparticles dispersed in a macroscopic region of a material or tissue produces a global temperature rise that is orders of magnitude larger than the temperature rise adjacent to a single nanoparticle. One approach for producing a significant local temperature rise on nanometer length scales is heating by high-power pulsed or modulated lasers with low duty cycle.
Total Lactational Response to Added Fat During Early Lactation (1991)

The theory that feeding cows additional fat during early lactation will result in greater total lactational production and improved reproductive efficiency was evaluated using 305-d lactational data from 94 cows fed control diets and 96 cows fed additional dietary fat during wk 4 through 16 postpartum. Added fat in diets was supplied by oilseeds, either soybeans or sunflowers, in previously reported studies. Milk yield during wk 4 through 16 postpartum was 2.8% higher for cows fed added fat. Total lactational yield was increased 3.6% for cows fed additional fat in early lactation; 71% of the additional milk production occurred after discontinuing the feeding of additional fat. Percentages of milk fat and protein were lower when cows were fed added fat and remained lower for the remainder of the lactation. Days to first breeding, days open, and services per conception were not reduced by feeding added fat during early lactation. Milk production and persistency for the entire lactation were increased by feeding additional fat during early lactation, but changes in reproductive efficiency were not detected.
ChemInform Abstract: 5,6‐O‐ISOPROPYLIDENE‐D‐GLUCOFURANOSE (1975)

Abstract Umsetzung von D‐Glucose (i) mit Cu‐sulfat in DMF/Aceton führt zu mehreren Produkten, von denen die Titelverbindung (II) sowie die Hexose (III) isoliert werden.
Magnetic properties and crystal structures of sputtered CoFe films. (1989)

Sputtered Co-(15-19) at%Fe films were prepared with Ar gas pressure and substrate temperature as parameters. Relationships between magnetic properties and crystal structures were investigated for these films. Films with an fcc phase (111) preferred orientation showed relatively high Hc values of more than 8 Oe and Bs of about 19 kG. Films with bcc phase (110) preferred orientation showed low Hc values of 2-3 Oe, which is comparable to values for single-layered Fe based films, and Bs of about 21 kG. It was confirmed that this difference in Hc is not attributable to differences in internal stress or crystallite diameter.
Apo2l/Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Prevents Breast Cancer–Induced Bone Destruction in a Mouse Model (2006)

Breast cancer is the most common carcinoma that metastasizes to bone. To examine the efficacy of recombinant soluble Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) against breast cancer growth in bone, we established a mouse model in which MDA-MB-231 human breast cancer cells were transplanted directly into the marrow cavity of the tibiae of athymic nude mice producing osteolytic lesions in the area of injection. All vehicle-treated control animals developed large lesions that established in the marrow cavity, eroded the cortical bone, and invaded the surrounding soft tissue, as assessed by radiography, micro-computed tomography, and histology. In contrast, animals treated with recombinant soluble Apo2L/TRAIL showed significant conservation of the tibiae, with 85% reduction in osteolysis, 90% reduction in tumor burden, and no detectable soft tissue invasion. Tumor cells explanted from Apo2L/TRAIL-treated animals were significantly more resistant to the effects of Apo2L/TRAIL when compared with the cells explanted from the vehicle-treated control animals, suggesting that prolonged treatment with Apo2/TRAIL in vivo selects for a resistant phenotype. However, such resistance was readily reversed when Apo2L/TRAIL was used in combination with clinically relevant chemotherapeutic drugs, including taxol, etoposide, doxorubicin, cisplatin, or the histone deacetylase inhibitor suberoylanilide hydroxamic acid. These studies show for the first time that Apo2L/TRAIL can prevent breast cancer-induced bone destruction and highlight the potential of this ligand for the treatment of metastatic breast cancer in bone.
CHEMISTRY OF AMINO ACIDS AND PEPTIDES (1960)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
The subcellular distribution of dystrophin in mouse skeletal, cardiac, and smooth muscle. (1991)

We use a highly specific and sensitive antibody to further characterize the distribution of dystrophin in skeletal, cardiac, and smooth muscle. No evidence for localization other than at the cell surface is apparent in skeletal muscle and no 427-kD dystrophin labeling was detected in sciatic nerve. An elevated concentration of dystrophin appears at the myotendinous junction and the neuromuscular junction, labeling in the latter being more intense specifically in the troughs of the synaptic folds. In cardiac muscle the distribution of dystrophin is limited to the surface plasma membrane but is notably absent from the membrane that overlays adherens junctions of the intercalated disks. In smooth muscle, the plasma membrane labeling is considerably less abundant than in cardiac or skeletal muscle and is found in areas of membrane underlain by membranous vesicles. As in cardiac muscle, smooth muscle dystrophin seems to be excluded from membrane above densities that mark adherens junctions. Dystrophin appears as a doublet on Western blots of skeletal and cardiac muscle, and as a single band of lower abundance in smooth muscle that corresponds most closely in molecular weight to the upper band of the striated muscle doublet. The lower band of the doublet in striated muscle appears to lack a portion of the carboxyl terminus and may represent a dystrophin isoform. Isoform differences and the presence of dystrophin on different specialized membrane surfaces imply multiple functional roles for the dystrophin protein.
Brightness Perception in Complex Fields (1967)

Results of brightness-scaling experiments with complex stimulus fields are reported. A family of brightness functions has been computed from the data for complex stimuli such as photographic reproductions viewed with both illuminated and dark surrounds. The resulting brightness vs luminance functions are not simple power functions. They exhibit exponential decay from the power form as a function of both screen luminance and surround luminance; i.e., they are nonlinear in log–log coordinates.
Genetic selection of non-linear product terms in the inputs to a linear classifier for handwritten digit recognition (2002)

The purpose of the study is to compare neural network and linear system based models in 2-D pattern recognition tasks. Using a linear classifier, non-linear inputs are generated based on the linear inputs using different forms of generating products. These nonlinear inputs form a candidate set from which nonlinear inputs are selected to improve classification performance. A genetic search is performed to find an appropriate set of non-linear inputs. The method is applied to the handwritten digit recognition problem. Results show that the linear model with linear inputs reaches a classification performance on the testing database of 79.3%. However, when nonlinear inputs selected by the genetic algorithm were used, and included as new inputs, the classification performance increased up to 92.8%. These results are compared with those of three non-linear neural network models widely used in classification tasks using the same database. A single-layer perceptron with linear inputs reached 81.0% of correct classification. Perceptron models having a single-hidden layer and two-hidden layers reached classification results of 90.1% and 92.5%, respectively. Therefore, these results show that a linear classifier with an appropriate set of non-linear inputs reached a classification performance similar or better than those obtained by nonlinear neural network classifiers with one and two-hidden layer and with linear inputs.
Systems Engineering of Datacasting for Public Safety Vehicles (2007)

Public safety officers need current, accurate and complete information to maintain the security of their communities. Existing communications systems for public safety officers consist of analog and digital radios, supplemented with cell phone communications. Dispatchers with a need to broadcast information can only do so via voice. Small data packets can be exchanged via point-to-point methods with modern digital radios, but no data broadcast exists for public safety communications. Broadcasting images, audio and text to officers in the field will offer a better collection of information necessary to make critical, time-sensitive public safety decisions. Live updates to in-vehicle databases and computer systems will provide officers with critical, up-to-the-minute information. Working with New Hampshire Public Television and the National Institute of Justice, we are researching a system to utilize excess bandwidth available in the public television broadcast spectrum. The system is to be implemented using the onboard data and car management system known as Project54 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> . The use of this excess bandwidth for the delivery of digital data in a one-way, high-speed, broadcast stream is called datacasting. While datacasting has existed since the initial draft ATSC standards defining digital television, few locations have installed full datacasting capabilities, and no other datacasting effort has implemented a mobile, two-way datacasting system. This paper will outline the design of the datacasting environment for the New Hampshire Department of Safety, the results of field tests performed by 10 State Police vehicles collecting data during routine public safety patrols, and the status of the two-way datacasting implementation.
Hepatic Fibrosis – Therapeutic Strategies (1998)

Review Articles| August 03 1998 Hepatic Fibrosis – Therapeutic Strategies Subject Area: Gastroenterology Detlef Schuppan; Detlef Schuppan Medizinische Klinik I, Universität Erlangen-Nürnberg, Deutschland Search for other works by this author on: This Site PubMed Google Scholar Deike Strobel; Deike Strobel Medizinische Klinik I, Universität Erlangen-Nürnberg, Deutschland Search for other works by this author on: This Site PubMed Google Scholar Eckhart G. Hahn Eckhart G. Hahn Medizinische Klinik I, Universität Erlangen-Nürnberg, Deutschland Search for other works by this author on: This Site PubMed Google Scholar Digestion (1998) 59 (4): 385–390. https://doi.org/10.1159/000007494 Article history Published Online: August 03 1998 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Detlef Schuppan, Deike Strobel, Eckhart G. Hahn; Hepatic Fibrosis – Therapeutic Strategies. Digestion 1 August 1998; 59 (4): 385–390. https://doi.org/10.1159/000007494 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsDigestion Search Advanced Search Article PDF first page preview Close Modal Keywords: Hepatic fibrosis, Antifibrotic agents 1998Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.