gebhart/patrepeval huggingface dataset:
Baseband speech coding at 2400 bps using "Spherical vector quantization" (2005)

This paper concerns a new Quantization Scheme for efficient encoding of waveforms below or about one bit per sample. This technique is then applied to the encoding of baseband residual signals to demonstrate the feasibility of (baseband) Residual Excited LPC at 2400 hit/sec. The technique called "Spherical Vector Quantization" is described in which a block of n consecutive samples is quantized as a vector. The magnitude of the vector is transmitted independently of the vector's orientation. This vector's orientation is vector quantized using a codebook which can be seen as representing a set of N points on a unit hypersphere. The cases for blocks of n = 8 and 24 are discussed which make use of results by Conway and Sloane on regular point lattices. For n = 8, the algorithm is detailed which solves both the problem of finding the closest point on the hypersphere and the problem of determining the index of that point. Experiments involving SVQ in coding the speech baseband residual are described which show in particular that subband coding does not contribute any quality improvement when SVQ is used.
Broadband analogue predistortion using a distortion generator based on two-stage RF mixer topology (2018)

An analogue predistorter using a distortion generator based on a two-stage radio frequency mixer topology is presented. The proposed distortion generator achieves fundamental signal cancellation without using a signal cancellation loop or a resonant circuit, thus it generates an error signal that predominantly consists of unwanted intermodulation distortion (IMD). Measurements are performed using multi-tones, WLAN- and Terrestrial Trunked Radio (TETRA)-modulated signals. Distortion generator provides high levels of IMD and achieves more than 40 dB fundamental signal cancellation across a bandwidth of 120 MHz. A proof-of-concept predistorter was constructed to validate the usefulness of the proposed distortion generator, which achieves up to 15 dB suppression of IMD and adjacent channel power ratio at the output of a power amplifier. Distortion generator and predistorter gave similar results at multiple frequencies between 920 MHz and 2 GHz, with different test signals having bandwidths ranging from 25 kHz to 120 MHz.
Antitumor properties of an anti-idiotypic monoclonal antibody in relation to N-glycolyl-containing gangliosides. (2000)

We examined the antitumor effects of 1E10 monoclonal antibody, an anti-idiotypic IgG to an IgM monoclonal antibody, named P3, that reacts specifically with N-glycolyl-containing gangliosides and also recognizes antigens in human breast and melanoma tumors. Two murine tumor cell lines positive for the P3 antibody, F3II mammary carcinoma (BALB/c) and B16 melanoma (C57BL/6), were employed. In BALB/c mice, vaccination with several i.p. doses at 14-day intervals of 50 microgram of 1E10 coupled to keyhole limpet hemocyanin in Freund's adjuvant, significantly reduced s.c. tumor growth of F3II carcinoma cells and the number of spontaneous lung metastases. Also, the effect of 1E10 as a biological response modifier on tumor lung colonization was evaluated in C57BL/6 mice injected i.v. with B16 melanoma cells. Interestingly, i.v. administration of 10 microgram of uncoupled 1E10 antibody, 10-14 days after inoculation of B16 cells, dramatically reduced the number of experimental metastases in comparison with lungs from mice treated with an irrelevant IgG. The present data suggest that this 'non-internal image' anti-idiotypic monoclonal antibody may activate more than one mechanism of antitumor response against melanoma and mammary tumor cells.
Copper‐Catalyzed Enantioselective Intramolecular Conjugate Addition/Trapping Reactions: Synthesis of Cyclic Compounds with Multichiral Centers (2007)

The Cu-catalyzed enantioselective conjugate addition of dialkylzinc to bis-alpha,beta-unsaturated carbonyl compounds followed by the intramolecular trapping of the zinc enolate in the presence of chiral phosphoramidite ligands was investigated. Cyclic and heterocyclic compounds with multichiral centers were formed as a mixture of two diastereomers with excellent diastereoselectivities (up to 99:1) and enantioselectivities (up to 94 % ee, ee=enantiomeric excess). The stereochemistry was determined to be trans,trans for the major products and trans,cis for the minor products. The absolute configuration of the cyclic compounds was assigned by comparison with the analogous adduct derived from trans-3-nonen-2-one and Et(2)Zn or the adduct obtained through conjugate addition of Me(2)Zn to trans-1-phenyl-non-2-en-1-one. Further transformation of these cyclic products into more complex compounds is under investigation in our laboratory.
So Much Writing, So Little Science: A Review of 37 Years of Literature on Edetate Sodium Chelation Therapy (1993)

Little valid scientific evidence is available. Although the postulated mechanisms of action for EDTA are biologically plausible and EDTA appears to be safe, it has not been proven effective. Indeed, the best evidence shows it to be ineffective. Therefore, EDTA chelation therapy should not be used in clinical practice to treat atherosclerosis.
Dendritic Silica Particles with Well-Dispersed Ag Nanoparticles for Robust Antireflective and Antibacterial Nanocoatings on Polymeric Glass (2018)

Robust nanocoatings with both antireflective (AR) and antibacterial properties for transparent plastic substrates are not only significantly attractive in science but also urgently needed in wide applications. However, it is still a great challenge to realize the fabrication of this kind of multifunctional nanocoatings on plastic/polymer substrates. In this work, a series of single-particle-layered nanocoatings were prepared by partially embedding dendritic fibrous nanosilica (DFNS) with well-dispersed Ag nanoparticles (NPs) onto the surface of poly(methyl methacrylate) (PMMA) polymeric glass via organic vapor treatment. The optimal coated PMMA slide not only exhibits the enhanced transmittance with the highest one of 94.5% but also shows excellent antibacterial activity (at least killing 80% bacteria) toward both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. Moreover, both long-term ultrasonic processing and pencil hardness tests proved strong adhesion of particles on PMMA substrate due to partial embedding. This work provides an exploration approach to construct the multifunctional nanocoatings on polymeric substrates for potential applications in various optical devices and daily touch plastic glass.
Effects of Neodymium Concentration on Optical Characteristics of Polycrystalline Nd:YAG Laser Materials (1996)

A neodymium‐doped yttrium‐aluminum garnet (Y 3 A1 5 O 12 , YAG) (Nd:YAG) ceramic that contained 0.3–4.8 at.% neodymium additives and exhibited nearly the same optical properties as those of a single crystal was fabricated by a solid‐state reaction method using high‐purity powders. Although the integrated absorption intensity of the 2 H 9/2 + 4 F 5/2 bands simply increased as the neodymium concentration in the YAG ceramics decreased, the fluorescence intensity of the 2.4 at.% Nd:YAG ceramic was the strongest among Nd:YAG ceramics with various neodymium concentrations and a 0.9 at.% Nd:YAG single crystal. An oscillation experiment was performed on a continuous‐wave (cw) laser with a diode‐laser exciting system using those ceramics and the single crystal. The oscillation threshold and slope efficiency in that analysis were 309 mW and 28%, respectively, for the 1.1 at.% Nd:YAG ceramics and 356 mW and 40%, respectively, for the 2.4 at.% Nd:YAG ceramics. The lasing characteristics of the ceramics in the present work were superior to those of a 0.9 at.% Nd:YAG single crystal that was fabricated by the Czochralski (Cz) method.
On the application of liquid‐crystal thermography for the nondestructive detection of delamination in composite structures (2008)

Abstract To prevent the catastrophic failure of composite structures, several nondestructive testing methods have been developed. In this study, a new technique to evaluate these structures by using thermochromic liquid crystal (TLC) thermography is presented. Temperature gradients produced by sensitive liquid‐crystals are used to detect delamination in composite specimens. The effects of constituent materials and delamination size/location are investigated. The results from TLC thermography are compared to those from infrared thermography. Finally, advantages/disadvantages of the new method are discussed. On the basis of the results from this study, it could be concluded that the TLC thermography can be used as an inexpensive nondestructive testing method in inspection of composite structures. POLYM. COMPOS., 2008. © 2008 Society of Plastics Engineers
Loading of Human Red Blood Cells with DNA and RNA (1976)

Human erythrocytes were suspended in Hank's solution containing mammalian or viral DNA or RNA. After dialysis at 0 degrees C first against water and subsequently against Hank's solution, and a further incubation at 37 degrees C, the erythrocytes were found to be loaded with the nucleic acids. The nucleic acid trapped in the erythrocytes exhibited up to 35 per cent of the external concentration.
Studies of Electrooxidation of Dextrose in Neutral Media (1969)

Electrooxidation of dextrose on platinized platinum electrodes has been studied in phosphate buffer at pH 7.4. Rest potentials are interpreted as mixed potentials. Galvanostatic curves have been observed to exhibit oscillatory voltage behavior. In the range of potentials investigated gluconic acid is observed as the reaction product and is found to inhibit oxidation of dextrose due to adsorption on the electrode surface. From the measurements of the adsorption characteristics of the acid, the oscillatory voltage behavior of the galvanostatic curves have been ascribed to kinetic effects of formation of the product and the potential dependence of its adsorption.
SRY-Box Containing Gene 17 Regulates the Wnt/β-Catenin Signaling Pathway in Oligodendrocyte Progenitor Cells (2011)

The SRY-box (Sox) transcription factors regulate oligodendrocyte differentiation, but their signaling targets are largely unknown. We have identified a major signal transduction pathway regulated by Sox containing gene 17 (Sox17) in the oligodendrocyte lineage. Microarray analysis in oligodendrocyte progenitor cells (OPCs) after Sox17 attenuation revealed upregulated genes associated with cell cycle control and activation of the Wingless and integration site (Wnt)/β-catenin pathway. Sox17 knockdown also increases the levels of cyclin D1, Axin2, and activated β-catenin. In OPCs, the expression pattern of Sox17, cyclin D1, and secreted Frizzled-related protein-1 in the presence of platelet-derived growth factor (PDGF) was coordinately accelerated by addition of thyroid hormone, indicating differentiation-induced regulation of Sox17 targets. In developing white matter, decreased total β-catenin, activated β-catenin, and cyclin D1 levels coincided with the peak of Sox17 expression, and immunoprecipitates showed a developmentally regulated interaction among Sox17, T-cell transcription factor 4, and β-catenin proteins. In OPCs, PDGF stimulated phosphorylation of glycogen synthase 3β and the Wnt coreceptor LRP6, and enhanced β-catenin-dependent gene expression. Sox17 overexpression inhibited PDGF-induced TOPFLASH and cyclin D1 promoter activity, and decreased endogenous cyclin D1, activated β-catenin, as well as total β-catenin levels. Recombinant Sox17 prevented Wnt3a from repressing myelin protein expression, and inhibition of Sox17-mediated proteasomal degradation of β-catenin blocked myelin protein induction. These results indicate that Sox17 suppresses cyclin D1 expression and cell proliferation by directly antagonizing β-catenin, whose activity in OPCs is stimulated not only by Wnt3a, but also by PDGF. Our identification of downstream targets of Sox17 thus defines signaling pathways and molecular mechanisms in OPCs that are regulated by Sox17 during cell cycle exit and the onset of differentiation in oligodendrocyte development.
A new species of Schismatoglottis (Araceae) from Sabah, Malaysia (2003)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Interactive Web Search by Graphical Query Refinement. (2001)

We propose a new Web search system that helps users clarify their information needs through interaction. The system represents the user’s information needs using a query graph: a set of graph objects. This graph is presented to the user and interactively refined until the user is satisfied with the documents retrieved. In this way, the user can find the desired documents even if his original information needs were unclear. This article describes the concept and outlines the system.
A new transglutaminase‐like from the ascidian <i>Ciona intestinalis</i><sup>1</sup> (1997)

A cDNA clone encoding a transglutaminase (TGase) was isolated from a cDNA library prepared from the larval stage of Ciona intestinalis. The cDNA sequence has an open reading frame encoding a protein of 696 amino acids and is about 36% identical to 11 other TGase sequences. In addition, the critical residues thought to form the catalytic center are conserved. The Ciona TGase (CiTGase) has an extension of 39 amino acids in the NH2-terminal region similar to that reported for keratinocyte TGases. A phylogenetic analysis among other types of TGases demonstrated that CiTGase represents a new type of the enzyme.
Elastic Constants of CaO in the Temperature Range 80°–270°K (1967)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation H. E. Hite, R. J. Kearney; Elastic Constants of CaO in the Temperature Range 80°–270°K. J. Appl. Phys. 1 December 1967; 38 (13): 5424–5425. https://doi.org/10.1063/1.1709348 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioJournal of Applied Physics Search Advanced Search |Citation Search
Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis (2003)

The role of the anti-apoptotic protein Bcl-2 in lung cancer remains controversial. In order to clarify its impact on survival in small and non-small cell lung cancer (NSCLC), we performed a systematic review of the literature. Trials were selected for further analysis if they provided an independent assessment of Bcl-2 in lung cancer and reported analysis of survival data according to Bcl-2 status. To make it possible to aggregate survival results of the published studies, their methodology was assessed using a quality scale designed by the European Lung Cancer Working Party (including study design, laboratory methods and analysis). Of 28 studies, 11 identified Bcl-2 expression as a favourable prognostic factor and three linked it with poor prognosis; 14 trials were not significant. No differences in scoring measurement were detected between the studies, except that significantly higher scores were found in the trials with the largest sample sizes. Assessments of methodology and of laboratory technique were made independently of the conclusion of the trials. A total of 25 trials, comprising 3370 patients, provided sufficient information for the meta-analysis. The studies were categorised according to histology, disease stage and laboratory technique. The combined hazard ratio (HR) suggested that a positive Bcl-2 status has a favourable impact on survival: 0.70 (95% confidence interval 0.57-0.86) in seven studies on stages I-II NSCLC; 0.50 (0.39-0.65) in eight studies on surgically resected NSCLC; 0.91 (0.76-1.10) in six studies on any stage NSCLC; 0.57 (0.41-0.78) in five studies on squamous cell cancer; 0.75 (0.61-0.93) and 0.71 (0.61-0.83) respectively for five studies detecting Bcl-2 by immunohistochemistry with Ab clone 100 and for 13 studies assessing Bcl-2 with Ab clone 124; 0.92 (0.73-1.16) for four studies on small cell lung cancer; 1.26 (0.58-2.72) for three studies on neuroendocrine tumours. In NSCLC, Bcl-2 expression was associated with a better prognosis. The data on Bcl-2 expression in small cell lung cancer were insufficient to assess its prognostic value.
Stimulation of Interferon β Production of Cultured Cells by Phospholipids in Foodstuffs (1992)

Journal Article Stimulation of Interferon β Production of Cultured Cells by Phospholipids in Foodstuffs Get access Tomoyuki Tahara, Tomoyuki Tahara Department of Food Science and Technology, Graduate School of Genetic Resources Technology, Faculty of Agriculture, Kyushu University 46–09, 6–10–1 Hakozaki, Higashi-ku, Fukuoka 812, Japan Search for other works by this author on: Oxford Academic Google Scholar Sanetaka Shirahata, Sanetaka Shirahata Graduate School of Genetic Resources Technology, Faculty of Agriculture, Kyushu University 46–09, 6–10–1 Hakozaki, Higashi-ku, Fukuoka 812, Japan Search for other works by this author on: Oxford Academic Google Scholar Kazuhiro Osada, Kazuhiro Osada Graduate School of Genetic Resources Technology, Faculty of Agriculture, Kyushu University 46–09, 6–10–1 Hakozaki, Higashi-ku, Fukuoka 812, Japan Search for other works by this author on: Oxford Academic Google Scholar Hirofumi Tachibana, Hirofumi Tachibana Graduate School of Genetic Resources Technology, Faculty of Agriculture, Kyushu University 46–09, 6–10–1 Hakozaki, Higashi-ku, Fukuoka 812, Japan Search for other works by this author on: Oxford Academic Google Scholar Kazuki Shinohara, Kazuki Shinohara National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Kannondai, Tsukuba, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroki Murakami Hiroki Murakami Graduate School of Genetic Resources Technology, Faculty of Agriculture, Kyushu University 46–09, 6–10–1 Hakozaki, Higashi-ku, Fukuoka 812, Japan To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 56, Issue 9, 1 January 1992, Pages 1465–1466, https://doi.org/10.1271/bbb.56.1465 Published: 01 January 1992 Article history Received: 11 December 1991 Published: 01 January 1992
Viral diseases of the respiratory system (1998)

Infectious bronchitis, Newcastle disease, infectious laryngotracheitis, avian influenza, and pneumovirus are the viruses that more frequently affect the respiratory tract of chickens. Because of the tendency to change its antigenic properties, infectious bronchitis is currently the viral disease present in most poultry producing areas of the world. New serotypes and variant strains are reported in several countries. Current commercially available vaccines do not always provide protection against new field isolates. Vaccination programs are constantly adjusted in an attempt to improve protection against this disease. Infectious laryngotracheitis has appeared in the broiler industry as a serious disease. Improved vaccines are needed to control the disease in broilers. In the U.S., the control of the highly pathogenic forms of avian influenza and the velogenic forms of Newcastle disease have been achieved by eradication. In other countries, effective vaccines have been used to control Newcastle and avian influenza. Avian pneumovirus infection is also an emerging disease of chickens and turkeys.
Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing (2012)

The RNA-binding protein DiGeorge Critical Region 8 (DGCR8) and its partner nuclease Drosha are essential for processing of microRNA (miRNA) primary transcripts (pri-miRNAs) in animals. Previous work showed that DGCR8 forms a highly stable and active complex with ferric [Fe(III)] heme using two endogenous cysteines as axial ligands. Here we report that reduction of the heme iron to the ferrous [Fe(II)] state in DGCR8 abolishes the pri-miRNA processing activity. The reduction causes a dramatic increase in the rate of heme dissociation from DGCR8, rendering the complex labile. Electronic absorption, magnetic circular dichroism, and resonance Raman spectroscopies indicate that reduction of the heme iron is accompanied by loss of the cysteines as axial ligands. ApoDGCR8 dimers, generated through reduction and removal of the heme, show low levels of activity in pri-miRNA processing in vitro. Importantly, ferric, but not ferrous, heme restores the activity of apoDGCR8 to the level of the native ferric complex. This study demonstrates binding specificity of DGCR8 for ferric heme, provides direct biochemical evidence for ferric heme serving as an activator for miRNA maturation, and suggests that an intracellular environment increasing the availability of ferric heme may enhance the efficiency of pri-miRNA processing.
Acute intoxication. (1990)

Acute alcohol intoxication is a commonly encountered clinical presentation in Emergency Medicine. Its role should be considered in many Emergency Department presentations, specifically in major and minor trauma, and in gastrointestinal, metabolic, neurologic, and psychiatric disorders. The differential diagnosis of change in mental status must be considered in all intoxicated patients. Management of intoxicated patients is generally supportive although complications of chronic alcoholism should be considered. Management should consist of correction of complications resultant from intoxication, as well as observation and the provision of a safe environment for the patient during the recovery phase of acute intoxication.
A flow cytometric method to estimate the precursor frequencies of cells proliferating in response to specific antigens (1999)

Fluorescent dyes that stain cell membranes or cytoplasm and then partition between daughter cells at division have been used in conjunction with flow cytometry to measure the proliferation of cells. In this paper, using peripheral blood mononuclear cells responding to tetanus toxoid, we describe an extension of this dye methodology to calculate the precursor frequency of antigen-specific T-cells. With mathematical deconvolution of the fluorescence histograms providing information about the proportion of cells in each of the daughter generations, information can be derived about the precursor frequency of cells in the original population that responded to the specific stimulus. Data from a model system with different proportions of fixed and viable cells indicate that the flow method returns accurate values for precursor frequency. Based on the characteristics of flow cytometric data acquisition, it is estimated that the flow method could detect proliferation of cells that represented, before addition of the stimulus, approximately 1/10(5) of the population. When comparing results to those from the limiting dilution technique, the flow cytometric method returns values that indicate higher precursor frequencies. Possible reasons for this discrepancy are discussed. The flow cytometric method offers the advantage of simplicity as well as the additional ability to phenotype the responding cells and determine their rate of proliferation. The flow method may find use as a simple, routine assay in the fields of allergy, transplant rejection, and autoimmunity and for quantitating responses to vaccination and cancer immunotherapy.