gebhart/patrepeval huggingface dataset:
Identification and Characterization of a Novel Human Histone H3 Lysine 36-specific Methyltransferase (2005)

Histone methylation plays an important role in eukaryotic transcriptional regulation. A number of histone methyltransferases (HMTases) with distinct functions have been identified. The HSPC069/HYPB gene was originally isolated from the human hematopoietic stem/progenitor cells (HSPCs), and it was also identified as a huntingtin interacting protein, implicated in the pathogenesis of Huntington disease (HD). However, its biochemical function is poorly understood. Here we report the structural and functional characterization of the huntingtin interacting protein B (HYPB). 1) The triplicate AWS-SET-PostSET domains mediate a histone H3 lysine 36 specific HMTase activity. 2) A low charged region that is rich in glutamine and proline has been characterized as a novel transcriptional activation domain. The structural features of this region are evolutionarily conserved in vertebrates. 3) Coimmunoprecipitation assays indicate that HYPB protein associates with hyperphosphorylated RNA polymerase II (RNAPII) but not the unphosphorylated form. Furthermore, the RNAPII-association region of HYPB protein has been identified to encompass the C-terminal 142 amino acids. Thus, our results suggest that HYPB HMTase may coordinate histone methylation and transcriptional regulation in mammals and open perspective for the further study of the potential roles of HYPB protein in hematopoiesis and pathogenesis of HD.
Hallux rigidus (2017)

An estimated 40% of the US population have foot problems. Of all patients aged over 50 years, 2.5% report degenerative arthritis of the first metatarsophalangeal (MTP) joint, termed ‘hallux rigidus’. First MTP osteoarthritis is the most common arthritic condition in the foot. Progression of great toe arthritis is associated with pain and loss of motion. Non-surgical intervention begins with shoe modifications and orthotics designed to limit MTP motion. In patients with mild arthritis, operative procedures focus on removing excess osteophytes (cheilectomy) to prevent dorsal impingement with or without a concomitant osteotomy (Moberg) to improve or shift range of motion into a less painful arc. In patients with more advanced arthritis, operative management has centred on arthrodesis of the first MTP joint. A recent Level 1 study shows excellent function and pain relief with a small hydrogel hemi-implant into the metatarsal head Multiple joint-sparing procedures such as joint arthroplasty or resurfacing have been described with inconsistent results. Cite this article: EFORT Open Rev 2017;2:13–20. DOI: 10.1302/2058-5241.2.160031
Urine Cystatin C as a Biomarker of Proximal Tubular Function Immediately after Kidney Transplantation (2011)

Urine CyC on the day after transplant differs between degrees of perioperative graft function and modestly corresponds with 3-month function.
Keynote: Land Care In Australia (2001)

Landcare in Australia, as a voluntary, community driven, 'middle of the road' conservation phenomenon, is a decade old. Landcare is a new -way of thinking and acting. The community, government, non government organizations and the corporate sector have created partnerships to address degradation of Australia's natural resource base: its soil, water and biodiversity. Awareness of natural resource issues and empowerment for individuals and communities to make a positive contribution to the environment has been outcomes of landcare activity. Government funding has been a catalyst for landcare projects and these works have been implemented in line with national and regional natural resource and environmental management strategies. Bipartisan political support, peak conservation and farmer group endorsement, community awareness and participation, and a national marketing and awareness campaign are the four ‘pillars' integral to the success of landcare in implementing change to more sustainable natural resource use. It is a unique model for achieving positive environmental and farming outcomes - with social and economic benefits for whole communities even nations.
Performance evaluation of rough set based classification models to intrusion detection system (2016)

Information and communication technology inflate day by day, due to rapid improvement in technologies has increased the need of effective IDS (Intrusion Detection System). Here, Intelligent Intrusion Detection method that is Rough Set based approach presented for performance evaluation of classifier abnormal behavior. Rough Set Theory is used to reduce the input data space, from complex databases and find minimal decision rules or reduct, through this we can manage complexity of system and manage huge network traffic. Rough set based effective classification models namely Rule based classifier algorithm with discretization, Decomposition tree algorithm and Decomposition tree with discretization have been applied to find reduced decision rules and classify problem. Comparison of classification results also have perform with various evaluation criteria and recognize best suited classifier for intrusion detection system dataset. This paper tries to achieve better accuracy and coverage using rough set based classifications. Then compare classification models performance using ROC(Receiver operating characteristic) curve with optimal visualization of results. Comparison of Classification models performance using ROC also done. These results provide robust, high accuracy, lowest false alarm rate and improve coverage of test data set. An empirical result shows the optimum classification result to big network data traffic.
Feature extraction from ear-worn sensor data for gait analysis (2014)

Gait analysis has a significant role in assessing human's walking pattern. It is generally used in sports science for understanding body mechanics, and it is also used to monitor patients' neuro-disorder related gait abnormalities. Traditional marker-based systems are well known for tracking gait parameters for gait analysis, however, it requires long set up time therefore very difficult to be applied in everyday realtime monitoring. Nowadays, there is ever growing of interest in developing portable devices and their supporting software with novel algorithms for gait pattern analysis. The aim of this research is to investigate the possibilities of novel gait pattern detection algorithms for accelerometer-based sensors. In particular, we have used e-AR sensor, an ear-worn sensor which registers body motion via its embedded 3-D accelerom-eter. Gait data was given semantic annotation using pressure mat as well as real-time video recording. Important time stamps within a gait cycle, which are essential for extracting meaningful gait parameters, were identified. Furthermore, advanced signal processing algorithm was applied to perform automatic feature extraction by signal decomposition and reconstruction. Analysis on real-word data has demonstrated the potential for an accelerometer-based sensor system and its ability to extract of meaningful gait parameters.
Comprehensive Shoulder US Examination: A Standardized Approach with Multimodality Correlation for Common Shoulder Disease (2016)

Shoulder pain is one of the most common musculoskeletal conditions encountered in primary care and specialty orthopedic clinic settings. Although magnetic resonance (MR) imaging is typically the modality of choice for evaluating the soft-tissue structures of the shoulder, ultrasonography (US) is becoming an important complementary imaging tool in the evaluation of superficial soft-tissue structures such as the rotator cuff, subacromial-subdeltoid bursa, and biceps tendon. The advantages of US driving its recent increased use include low cost, accessibility, and capability for real-time high-resolution imaging that enables dynamic assessment and needle guidance. As more radiologists are considering incorporating shoulder US into their practices, the development of a standardized approach to performing shoulder US should be a priority to facilitate the delivery of high-quality patient care. Familiarity with and comfort in performing a standardized shoulder US examination, as well as knowledge of the types of anomalies that can be evaluated well with US, will enhance the expertise of those working in musculoskeletal radiology practices and add value in the form of increased patient and health care provider satisfaction. This review describes the utility and benefits of shoulder US as a tool that complements MR imaging in the assessment of shoulder pain. A standardized approach to the shoulder US examination is also described, with a review of the basic technique of this examination, normal anatomy of the shoulder, common indications for shoulder US, and characteristic US findings of common shoulder diseases-with select MR imaging and arthroscopic correlation. Online supplemental material is available for this article. <sup>©</sup>RSNA, 2016.
Intermittent scan chain fault diagnosis based on signal probability analysis (2004)

A new algorithm to diagnose intermittent scan chain fault in scan-based designs is proposed in this paper. An intermittent scan chain fault sometimes is triggered and sometimes is not triggered during scan chain shifting, which makes it very difficult to locate the fault sites. In this paper, we provide answers to three questions: (1) Why intermittent scan chain faults happen? (2) Why diagnosis of this type of faults is necessary? (3) How to diagnose this type of faults? The experimental results presented demonstrate that the proposed diagnosis algorithm is effective for large industrial designs with multiple intermittent scan chain faults.
Sub Contractor Life Cycle Management In Enterprise System Using Blockchain Technology (2021)

Sub Contractor Life Cycle Management is one of the critical jobs for various industries, there are many flaws and issues in the existing operational management of SubContracting through enterprise systems. Existing issues in Sub Contractor Management System (Life Cycle Management System on-boarding, extending and releasing to be precise), causes a delay in on-boarding and extension of sub-contractors which directly impacts the revenue of an organization. Typically IT Organization suffers an annual revenue loss of 3-5%. The Operations Management (for Sub Contractor Onboarding / Project Extension) involves the interference of various Sub Systems in an organization like Talent Management System, Human Resource Management System, Finance Management System, Time Sheet Management System, Project Management Systems, Vendor Management System. Synchronizing of data and audit process across such different (maybe heterogeneous) system, (heterogeneous because each system might have a different mechanism in storing data) is also a big challenge. There is a lack of visibility and control for each actor involved in the sub-contractor management life cycle. Authors in this literature have proposed a blockchain-based solution to counter the above issue(s) and the system promises to bring down the revenue loss w.r.t Subcontractor Life Cycle management system to 0.1 % - 0.5 %, by leveraging the feature of blockchain to provide better visibility, trust, real-time monitoring of information/data related to Sub-Contractor by integrating the end-points (Blockchain as a Service) where each subsystem is added as a node in the blockchain network, each event (transaction in blockchain world) happening in any subsystem will be updated on the blockchain ledger using Smart Contract or Chaincode, which will provide single source of truth, transparency, end to end visibility in the entire digital operations.
Synthesis of the Lantibiotic Lactocin S Using Peptide Cyclizations on Solid Phase (2009)

Lactocin S is a lantibiotic peptide with potent antibacterial activity against a range of gram-positive bacteria. Because of challenges in obtaining sufficient quantities of this compound from natural sources, the stereochemistry of the lanthionine residues in lactocin S had not been confirmed. This report describes the chemical synthesis of lactocin S on chlorotrityl polystyrene resin in 10% overall yield using intramolecular cyclization to form the lanthionine rings and employing fragment coupling for the two N-terminal residues. This represents the first report of solid-supported synthesis of a naturally occurring lantibiotic. Comparison to lactocin S isolated from Lactobacillus sakei L45 using a combination of HPLC, MS/MS sequencing, bacterial testing, and chiral GC-MS analysis confirmed the initially proposed structure and the stereochemistry of the DL-lanthionine residues.
A New Chemoenzymatic Enantioselective Synthesis of Optically Active Benzothiopyran and Benzothiazepin Ring System (1991)

A simple enantiocontrolled synthesis of (R)-2-methyl-2,3-dihydro-4H-[1]benzothiopyran-4-one and (R)-2-methyl-2,3-dihydro-1,5 -benzothiazepin-4(5H)-one starting from ethyl (S)-3-hydroxybutyrate is described.
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells (2008)

The proprotein convertases (PCs) are implicated in the activation of various precursor proteins that play an important role in tumor cell metastasis. Here, we report their involvement in the regulation of the metastatic potential of colorectal tumor cells. PC function in the human and murine colon carcinoma cell lines HT-29 and CT-26, respectively, was inhibited using siRNA targeting the PCs furin, PACE4, PC5, and PC7 or by overexpression of the general PC inhibitor alpha1-antitrypsin Portland (alpha1-PDX). We found that overexpression of alpha1-PDX and knockdown of furin expression inhibited processing of IGF-1 receptor and its subsequent activation by IGF-1 to induce IRS-1 and Akt phosphorylation, all important in colon carcinoma metastasis. These data suggest that the PC furin is a major IGF-1 receptor convertase. Expression of alpha1-PDX reduced the production of TNF-alpha and IL-1alpha by human colon carcinoma cells, and incubation of murine liver endothelial cells with conditioned media derived from these cells failed to induce tumor cell adhesion to activated murine endothelial cells, a critical step in metastatic invasion. Furthermore, colon carcinoma cells in which PC activity was inhibited by overexpression of alpha1-PDX when injected into the portal vein of mice showed a significantly reduced ability to form liver metastases. This suggests that inhibition of PCs is a potentially promising strategy for the prevention of colorectal liver metastasis.
Donor killer immunoglobulin-like receptor genes and reactivation of cytomegalovirus after HLA-matched hematopoietic stem-cell transplantation: HLA-C allotype is an essential cofactor (2013)

Natural killer (NK) cells whose killer immunoglobulin-like receptors (KIRs) recognize human leukocyte antigen (HLA) ligand are "licensed" for activity. In contrast, non-licensed NK cells display KIRs for which ligand is absent from the self genotype and are usually hyporesponsive. Surprisingly, non-licensed cells are active in tumor control after hematopoietic stem-cell transplantation (HSCT) and dominate NK response to murine cytomegalovirus (CMV) infection. From those reports, we hypothesized that control of human CMV early after HSCT is influenced by donor KIR genes whose HLA ligand is absent-from-genotype of HLA-matched donor and recipient. To investigate, we studied CMV reactivation through Day 100 after grafts involving CMV-seropositive donor and/or recipient. A multivariate proportional rates model controlled for variability in surveillance and established covariates including acute graft-versus-host disease; statistical significance was adjusted for testing of multiple KIRs with identified HLA class I ligand (2DL1, 2DL2/3, 2DS1, 2DS2, full-length 2DS4, 3DL1/3DS1, 3DL2). Among HSCT recipients (n = 286), CMV reactivation-free survival time varied with individual donor KIR genes evolutionarily specific for HLA-C: when ligand was absent from the donor/recipient genotype, inhibitory KIRs 2DL2 (P < 0.0001) and 2DL1 (P = 0.015) each predicted inferior outcome, and activating KIRs 2DS2 (P < 0.0001), 2DS1 (P = 0.016), and 2DS4 (P = 0.016) each predicted superior outcome. Otherwise, with ligand present-in-genotype, donor KIR genes had no effect. In conclusion, early after HLA-matched HSCT, individual inhibitory and activating KIR genes have qualitatively different effects on risk of CMV reactivation; unexpectedly, absence of HLA-C ligand from the donor/recipient genotype constitutes an essential cofactor in these associations. Being KIR- and HLA-C-specific, these findings are independent of licensing via alternate NK cell receptors (NKG2A, NKG2C) that recognize HLA-E.
Automatic High-Throughput Detection of Fluid Inclusions in Thin-Section Images using a Novel Algorithm (2014)

Detection and examination of fluid inclusions can lead to insight into diagenesis and history of a hydrocarbon reservoir. Currently, geologists are faced with a large collection of digital images, making manual investigation highly inefficient and time-consuming. A combination of data acquisition by simple and robust light microscopy and an advanced downstream computational solution is ideal with respect to cost efficiency and stable large-scale and high-throughput ability. Moreover, a strict deterministic algorithm for automatic fluid inclusion detection is not subjected to any human biases that would otherwise violate detection consistency. A novel algorithm for fluid inclusion detection has been developed and implemented in the statistical scripting language R and the object-oriented programming language C# under the .NET 4.0 computational framework. The algorithm is a result of thorough understanding of the image representation of fluid inclusions and optimized based on empirical correlations. It is based on sequential image section-specific intensity-centric selection criteria, intensity distribution discrimination and conditional statistics. Moreover, a multi-dimensional scoring-scheme has been developed and implemented. The software was able to successfully identify a series of fluid inclusions on the same thin-section image containing hydrocarbon and aqueous phases, respectively. Due to the modular structure the software is highly flexible and can be tailor-made to specific analytical needs, such as selective identification of solid phases.
TREATMENT OF METALS, POLYMER FILMS, AND FABRICS WITH A ONE ATMOSPHERE UNIFORM GLOW DISCHARGE PLASMA (OAUGDP) FOR INCREASED SURFACE ENERGY AND DIRECTIONAL ETCHING (2001)

Direct exposure of samples to the active species of air generated by a One AtmosphereUniform Glow Discharge Plasma (OA UGDP) has been used to etch and to increasethe surface energy of metallic surfaces, photoresist, polymer films, and nonwoven fab-rics. The OAUGDP is a non-thermal plasma with the classical characteristics of aDC normal glow discharge that operates in air (and other gases) at atmospheric pres-sure. Neither a vacuum system nor batch processing is necessary. A wide range ofapplications to metals, photoresist, films, fabrics, and polymeric webs can be accom-modated by direct exposure of the workpiece to the plasma in parallel-plate reactors.This technology is simple, it produces effects that can be obtained in no other way atone atmosphere; it generates minimal pollutants or unwanted by-products; and it issuitable for individual sample or online treatment of metallic surfaces, wafers, films.and fabrics.``Early exposures of solid materials to the OA UGDP required minutes to produce rela-tively small increases of surface energy. These durations appeared too long for com-mercial application to fast-moving webs. Recent improvements in OA UGDP gas com-position, power density, plasma quality, recirculating gas flow, and impedance match-ing of the power supply to the parallel plate plasma reactor have made it possible toraise the surface energy ofa variety of polymeric webs (PP, PET, PE, etc.) to levels of60 to 70 dynes/crn with one second of exposure. In air plasmas, the high surface ener-gies are not durable, and fall to 50 dynes/em after periods of weeks to months. Here.we report the exposure of metallic surfaces, photoresist, polymeric films, and nonwo-ven fabrics made of PP and PET to an impedance matched parallel plate OA UGDPfor durations ranging from one second to several tens of seconds. Data will be re-ported on the surface energy, wettability, wickability, and aging effect of polymericfilms and fabrics as functions of time of exposure, and time after exposure; the rateand uniformity of photoresis
Superdirective antennas with passive reflectors (1995)

A brief introduction to the problem of superdirective radiation in antenna theory, and a solution to the problem of wave scattering from a structure, formed by resonant scatterers, is presented. The paper describes construction of a two-dimensional superdirective antenna with one active element, and a reflector made of resonant scatterers-unclosed cylinders proposed by Veremey and Shestopalov (see Radio Science, vol.26, no.2, p. 631-636, 1991). Physical phenomena, which cause the effect of superdirective radiation, are studied in detail. It is shown that the interaction between the resonant elements leads to the possibility of exciting a mode characterized by a high level of reactive power, in the vicinity of a passive structure. Particular attention is paid to the sensitivity of the superdirective antenna, and to tolerance constraints. It is shown that changes of the angular width of a slot in an unclosed cylinder (or in several unclosed cylinders), within /spl plusmn/1%, do not lead to the destruction of the superdirective resonance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Direct laser writing of superconducting patterns of Y1Ba2Cu3O7−δ (1988)

Direct argon ion laser writing of 40-μm-wide and 3-μm-thick superconducting lines of Y1Ba2Cu3O7−δ on magnesium oxide (MgO) substrate is reported. A 514.5 nm laser beam of 300 mW was focused onto a thin sprayed film of the nitrate precursors (Y:Ba:Cu=1:2:3) and scanned over it. The laser beam converted oxides along the irradiation path. The film was then ‘‘developed’’ by rinsing it in ethanol, which removed the unirradiated areas, but left the irradiated areas intact. This was followed by the standard oven annealing procedure in flowing oxygen. The resistivity of the laser-written lines as a function of temperature showed an onset and completion of the superconducting transition at 82 and 69 K, respectively. The corresponding values of the unpatterned, blanket film were 82 and 77 K, respectively.