gebhart/patrepeval huggingface dataset:
An interpolative bandpass converter on a 1.2 mu m BiCMOS analog/digital array (1992)

The architecture and performance of an interpolative bandpass A/D converter and digital quadrature demodulator for the cellular radio mobile receiver is presented. A prototype version has been implemented on a 1.2 mu m/7 GHz BiCMOS analog/digital array. A bandpass signal centered at 6.5 MHz with 200 kHz bandwidth is demodulated and converted with a 55 dB signal-to-noise ratio resulting in 9-b performance. Using FFT analysis the baseband spectrum of the I and Q signals is generated. The signal-to-noise ratio in the baseband is better than 55 dB or 9-b, which is sufficient for cellular radio application.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Persistent Short Stature in Children with Intrauterine Growth Retardation: Use of Growth Hormone Treatment (1997)

Since the early 1970s, it has been demonstrated that growth hormone (GH) treatment improves the short-term growth rate of children with short stature due to intrauterine growth retardation (IUGR). However, it is only in recent years that studies have been conducted in which children with IUGR have been followed to final height. It is appreciated that pharmacological doses of GH are required for the treatment of short children with IUGR, and that the initial effect of rapid advancement of epiphyseal maturation is probably due more to the natural history of growth in children with IUGR than to the GH treatment. Initial studies are promising, showing that the rapid improvement in growth rate is eventually translated into an improvement in final height. However, studies involving a larger number of children with IUGR are necessary in order to quantify this improvement in final height.
Revised concept for the estimation of insulin sensitivity from a single sample. (1999)

Insulin resistance is common in the general population and is related to glucose intolerance, dyslipidemia, and high blood pre s s u re. Accurate and re p ro d u c i b l e methods for measuring insulin sensitivity in vivo, such as the euglycemic clamp or the minimal model pro c e d u re, re q u i re trained personnel and are rather expensive (1). There is undoubtedly a need for simpler tests, especially in the field of larg e epidemiological studies. The circ u l a t i n g level of insulin has been widely used as a s u rrogate for insulin sensitivity, since a high plasma insulin concentration is supposed to re flect a state of insulin re s i stance, when the insulin-glucose feedback is considered. Diff e rent indexes have been p roposed from baseline values of plasma insulin and glucose. Actually, there is a paradox concerning this approach, since both the product of fasting insulin and fasting glucose and their ratio are found to be correlated with insulin sensitivity. R e c e n t l y, Kahn et al. (2) supported the concept that a hyperbolic relationship existed between fasting insulin and insulin sensitivi t y. Such a relationship could be described by a formula on the model of insulin sensitivity (SI) = a/insulin (I), where the coeff icient a would be a constant. There f o re, the general ratio a/I could be proposed as a new index of insulin sensitivity. First, we tried to determine a value for
SmartStore (2009)

Existing storage systems using hierarchical directory tree do not meet scalability and functionality requirements for exponentially growing datasets and increasingly complex queries in Exabyte-level systems with billions of files. This paper proposes semantic-aware organization, called SmartStore, which exploits metadata semantics of files to judiciously aggregate correlated files into semantica-ware groups by using information retrieval tools. Decentralized design improves system scalability and reduces query latency for complex queries (range and top-k queries), which is conducive to constructing semantic-aware caching, and conventional filename-based query. SmartStore limits search scope of complex query to a single or a minimal number of semantically related groups and avoids or alleviates brute-force search in entire system. Extensive experiments using real-world traces show that SmartStore improves system scalability and reduces query latency over basic database approaches by one thousand times. To the best of our knowledge, this is the first study implementing complex queries in large-scale file systems.
Superior Vena Caval Obstruction (2006)

The initial paper on superior vena caval (SVC) obstruction was reported in 1757 byWilliam Hunter in a case caused by a syphilitic aortic aneurysm (1). Presently, the mostcommon cause of this syndrome is malignancy (80-90% of presentations) (2). The mostfrequent reported malignancy causing this syndrome is bronchogenic cancer; howevermany other types of mediastinal neoplasms have also been cited to cause this syndromeincluding lymphomas, thymomas, teratomas, germ cell tumors, metastatic tumors etc.
Oxygen-Dependent Microbial Killing by Phagocytes (1978)

THE part played by phagocytes in defense against invading pathogens has been recognized since 1883. In that year, Metschnikoff, a Russian zoologist, reported that foreign particles injected into metazoans (in Metschnikoff's experiments, starfish larvae) were taken up by a population of "wandering mesodermal cells" that resided in interstitial tissues.1 He postulated a crucial role in host defense for these wandering cells, which he named "phagocytes." Since Metschnikoff's discovery, hundreds of scientists studying dozens of species have reported thousands of studies on these cells, perhaps the most widely recognized of which are those of the eminent English physician Sir Colenso Ridgeon . . .
Central and Juxta-Endplate Vertebral Body Screw Placement (2002)

Bicortical fixation is much stronger than unicortical fixation. Centrally placed screws are significantly stronger when used with a staple. When preservation of segmental vessels is desirable, juxta-endplate screws should be placed in such a manner that compressive forces are directed away from the endplate.
IP storage and stored content management using SIP presence server with XML database (2011)

There are few studies of content delivery systems specializing in consumer generated video (CGV) exchange, and as for the real exchange technique, exchange through the file server in a network has become mainstream. A solution using P2P has been also proposed, but a structure for safe content exchange guaranteed by the service provider is necessary for the further spread of a service. Therefore, we propose a distributed storage video on demand system (DSVS) for delivering CGV content stored in a user IP storage. It is important to know how the server in a network manages stored CGV(s), including the storage. A standard system for managing the storage and also the stored files does not exist. Thus, we propose a storage management system, a part of our DSVS, that uses a session initiation protocol presence function and an XML database management system. These are additional functions of the IP multimedia subsystem, which is a core system of the next generation network (NGN). In Japan, access services for the IPv6 Internet and an NGN with one IPv6 address began in 2011. Therefore, the number of potential NGN users will increase with the spread of the IPv6 Internet access service. We show that our system can become the foundation of various content delivery services due to the versatility of the storage management capability of our DSVS.
Method to sense single-particle motion using a tapered-gap microcapacitor (2004)

We present an approach to study the real-time dynamics of single molecules using capacitance measurements. The method is based on a nonparallel-plate microcapacitor, which has a tapered-gap geometry. A particle moving within such a capacitor induces capacitance changes that depend on its position. Monitoring these changes allows motion to be traced at a resolution which is higher than the smallest fabricated feature of the device. The detection scheme also enables the distinction between particles of different dielectric constants and the exertion of dielectrophoretic forces on the particles. This approach provides a means for studying various aspects of single-particle dynamics at high resolution, in real time, and under conditions compatible with biological systems.
Susceptibility of mice to rotavirus infection: effects of age and administration of corticosteroids (1981)

We examined susceptibility to the murine rotavirus, epizootic diarrhea of infant mice virus (EDIM), in normal suckling and weaned mice and in suckling mice treated with glucocorticoids. Normal mice 1 to 40 days old were inoculated by gastrin intubation with high doses of EDIM and subsequently evaluated for rotavirus infection by solid-phase radioimmunoassay, by electron microscopy of intestinal tissue sections or by both. Radioimmunoassay and electron microscopy showed a concordance of 89.5% in the detection of rotavirus infection. After a period of low susceptibility to EDIM infection during the first 3 days after birth (23%), susceptibility was high for the next 11 days (95%), but decreased abruptly as mice approached weaning (41% on days 15 through 17). Mice 34 days or older did not develop EDIM infection after inoculation, but rotavirus antigen was detected in 12% of uninoculated mothers nursing inoculated litters. Administration of cortisone acetate to 8-day-old mice induced partial intestinal maturation prematurely. At 3 to 6 days after cortisone acetate treatment, susceptibility to EDIM infection decreased to 60% compared with 94% in age-matched controls. Our data suggest (i) that susceptibility of mice to EDIM infection is age dependent, decreasing in concert with intestinal maturation, and (ii) that glucocorticoids, which induce premature partial intestinal maturation, modulate susceptibility of mice to EDIM.
Plasma Etch Process Diagnosis and Control By Wireless Sensor Wafer in Semiconductor Chip Manufacturing (2006)

Plasma etch in semiconductor chip manufacturing is a complex process. The final process performance depends strongly on process parameters and their distributions at the surface of production wafers in an etch chamber. Until recently, there was no known technique that could monitor such critical parameters in-situ at the wafer surface before. In this paper the authors discuss an innovative technology where novel wireless sensor wafers (PlasmaTemptrade) are combined with advanced chamber diagnostic modeling techniques (PlasmaRxtrade) to provide a powerful solution-focused system for in-situ etch chamber component health monitoring, questionable component identification, and further corrective action
<b>A single point mutation of hamster aminoacyl‐tRNA synthetase causes apoptosis by deprivation of cognate amino acid residue</b> (1996)

Our data suggested that the defect in aminoacyl-tRNA synthetase turned on the cascade of apoptosis that was already present in the cells.
The Case for an Informed Path Selection Service (2008)

With today's peer-to-peer applications, more and more content is available from multiple sources. In tomorrow's Internet hosts will have multiple paths to reach one destination host with the deployment of dual-stack IPv4/IPv6 hosts, but also with new techniques such as shim6 or other locator/identifier mechanisms being discussed within the IRTF RRG. All these hosts will need to rank paths in order to select the best paths to reach a given destination/content. In this draft, we propose an informed path selection service that would be queried by hosts and would rank paths based on policies and performance metrics defined by the network operator to meet his traffic engineering objectives. A companion document describes a protocol that implements this service.
Segmentation and classification of various types of cells in cytological images (1992)

International audience
Cytokine induction of leucocyte adhesion molecule-1 (LAM- 1) expression on chronic lymphocytic leukaemia cells. (1992)

Leucocyte adhesion molecule 1 (LAM-1) participates in the binding of human leucocytes to high endothelial venules in peripheral lymph nodes. Other adhesion receptors which are involved include CD44 and the integrin family, CD11/CD18. In this study, B-cell chronic lymphocytic leukemia (B-CLL) cells were examined for the expression of these adhesion molecules, and for the way in which cytokines are able to modulate the levels of these receptors. B-CLL cells express significant but variable levels of LAM-1 and high levels of CD44. In contrast, these cells exhibit very low or absent amounts of surface CD11a, CD11b, or CD11c. Most CLL cells expressed no detectable levels of intercellular adhesion molecule-1 but some cases show levels of up to 30%. Following 24 h incubation with interferon alpha (500 U/ml), surface LAM-1 expression on peripheral blood E-negative cells from CLL patients rose to 330 +/- 127% of levels on control cells incubated with medium alone (n = 13, p less than 0.0005). Interleukin 4 (1 ng/ml) and interferon gamma (100 U/ml) also increased surface LAM-1 levels on these cells to 218 +/- 119% (n = 8, p less than 0.001) and 245 +/- 116% (n = 5, p less than 0.001) of control levels respectively. Induction of LAM-1 expression occurred over 48 h (greater than 50% of the increase was seen in the first 24 h) in a dose-dependent manner and required protein synthesis. The induction of LAM-1 expression on the malignant cells may, by altering the homing behaviour of these cells, relate to the reduction in peripheral leukaemic cells seen following treatment with interferon alpha in CLL.
Dynamic Studies of Struve Double Stars: STF4 and STF 236AB Appear Gravitationally Bound (2015)

Dynamics of two Struve double stars, WDS 00099+0827 (STF 4) and WDS 02556+2652 (STF 326 AB) are analyzed using astrometric criteria to determine their natures as gravitationally bound or unbound systems. If gravitationally bound, then observed relative ve- locity will be within limits according to the orbital energy conservation equation. Full imple- mentation of this criterion was possible because the relative radial velocities as well as proper motions have been estimated. Other physical parameters were taken from literature or estimated using published protocols. Monte Carlo analysis indicates that both pairs have a high probability of being gravitationally bound and thus are long-period binaries.
Synthesis of diadenosine 5',5'''-P1,P4-tetraphosphate (AppppA) from adenosine 5'-phosphosulfate and adenosine 5'-triphosphate catalyzed by yeast AppppA phosphorylase (1988)

A novel way of enzymatic synthesis of diadenosine 5',5"'-P1,P4-tetraphosphate (AppppA), which does not involve aminoacyl-tRNA synthetases, has been discovered. Yeast AppppA alpha, beta-phosphorylase catalyzes irreversible conversion of adenosine 5'-phosphosulfate (APS) and ATP into AppppA according to the equation APS + ATP----AppppA + sulfate. In this reaction, the enzyme exhibits a broad pH optimum (between 6 and 8) and requires Mn2+, Mg2+, or Ca2+ ions for activity, with Mn2+ being twice as effective as Mg2+ or Ca2+ at optimal concentration (0.5 mM). The Km values computed for APS and ATP are 80 microM and 700 microM, respectively. The rate constant for the AppppA synthesis is 3 s-1 (pH 8.0, 30 degrees C, 0.5 mM MgCl2). Some ATP analogues like ppppA, GTP, adenosine 5'-(alpha, beta-methylenetriphosphate), and adenosine 5'-(beta, gamma-methylenetriphosphate), but not dATP, UTP, or CTP, are also substrates for AppppA phosphorylase and accept adenylate from APS with the formation of AppppA, AppppG, Appp(CH2)pA, and App(CH2)ppA, respectively. Functional versatility of yeast AppppA phosphorylase may provide a link between metabolism of AppppA on one hand and metabolism of APS and phosphate on the other and raises the possibility of participation of AppppA in regulation of metabolism of APS and/or inorganic phosphate in yeast.
Asymmetric total synthesis of (+)-jasplakinolide (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric total synthesis of (+)-jasplakinolideKent S. Chu, George R. Negrete, and Joseph P. KonopelskiCite this: J. Org. Chem. 1991, 56, 17, 5196–5202Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://doi.org/10.1021/jo00017a037RIGHTS & PERMISSIONSArticle Views804Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Lipoid Proteinosis: Report of Four Siblings and Brief Review of the Literature (2001)

Lipoid proteinosis (Urbach-Wiethe disease) is a rare autosomal recessive disorder associated with deposition of periodic acid-Schiff (PAS)-positive hyaline material in various tissues including skin, mucous membranes, and internal organs. A family is reported in which four siblings (two boys and two girls) born to nonconsanguineous parents had lipoid proteinosis. All had the characteristic hoarseness of voice and three had skin lesions. The diagnosis was confirmed by the presence of typical features on light and electron microscopy.
Phase III Randomized, Double-Blind Study Comparing Single-Dose Intravenous Peramivir with Oral Oseltamivir in Patients with Seasonal Influenza Virus Infection (2011)

Antiviral medications with activity against influenza viruses are important in controlling influenza. We compared intravenous peramivir, a potent neuraminidase inhibitor, with oseltamivir in patients with seasonal influenza virus infection. In a multinational, multicenter, double-blind, double-dummy randomized controlled study, patients aged ≥ 20 years with influenza A or B virus infection were randomly assigned to receive either a single intravenous infusion of peramivir (300 or 600 mg) or oral administration of oseltamivir (75 mg twice a day [b.i.d.] for 5 days). To demonstrate the noninferiority of peramivir in reducing the time to alleviation of influenza symptoms with hazard model analysis and a noninferiority margin of 0.170, we planned to recruit 1,050 patients in South Korea, Japan, and Taiwan. A total of 1,091 patients (364 receiving 300 mg and 362 receiving 600 mg of peramivir; 365 receiving oseltamivir) were included in the intent-to-treat infected population. The median durations of influenza symptoms were 78.0, 81.0, and 81.8 h in the groups treated with 300 mg of peramivir, 600 mg of peramivir, and oseltamivir, respectively. The hazard ratios of the 300- and 600-mg-peramivir groups compared to the oseltamivir group were 0.946 (97.5% confidence interval [CI], 0.793, 1.129) and 0.970 (97.5% CI, 0.814, 1.157), respectively. Both peramivir groups were noninferior to the oseltamivir group (97.5% CI, <1.170). The overall incidence of adverse drug reactions was significantly lower in the 300-mg-peramivir group, but the incidence of severe reactions in either peramivir group was not different from that in the oseltamivir group. Thus, a single intravenous dose of peramivir may be an alternative to a 5-day oral dose of oseltamivir for patients with seasonal influenza virus infection.
An effective algorithm for mining sequential generators (2011)

Mining frequent sequences patterns invokes the interests of many searchers. However, the result set of frequent sequences is tremendous. While frequent sequential generator patterns can compact the result set of frequent sequences greatly and are superior to the frequent sequential closed patterns in classification and model selection. The existing sequential generator patterns mining algorithm fails to make full use of the relationship between a sequence and its subsequence. And when mining the frequent sequential generators, the existing algorithms are ineffective and inefficient. In order to resolve this problem, an effective and efficient algorithm is presented. A lot of experiments about the performance on datasets are conducted. The results show that the algorithm proposed is better than the existing algorithms for mining the sequential generators.
Rationale and design of the Dietary Approaches to Stop Hypertension trial (DASH) (1995)

Epidemiologic studies have found that dietary patterns characterized by high intakes of certain minerals and fiber are associated with low blood pressure. Dietary Approaches to Stop Hypertension (DASH) is a multicenter, randomized, controlled-feeding trial designed to test the effects on blood pressure of two such dietary patterns consumed for 8 weeks. The two experimental diets will be compared with each other and with a control dietary pattern that is relatively low in potassium, magnesium, calcium, and fiber, and has a fat and protein profile mirroring current US consumption. The first experimental diet, arguably termed “ideal,” is high in fruits, vegetables, whole cereal products, low-fat dairy products, fish, chicken, and lean meats designed to be low in saturated fat and cholesterol; moderately high in protein; and high in minerals and fiber. The second experimental diet tests the effect of fruits and vegetables alone. Its potassium, magnesium, and dietary fiber content will be at the same high levels as the ideal dietary pattern, while its fat, protein, and calcium content will resemble that of the control dietary pattern. The study population will consist of 456 healthy men and women, aged 22 years or older, with systolic blood pressure less than 160 mm Hg and diastolic blood pressure 80 to 95 mm Hg. African-American and other minority groups will comprise 67% of the population. Participants will eat one of the three dietary patterns. The DASH trial has unique features. First, dietary patterns rather than single nutrients are being tested. Second, all food for the experimental diets is provided to the participants using a standardized multicenter protocol. Because the dietary patterns are constructed with commonly consumed food items, the results, if positive, may be conveniently implemented in dietary recommandations to the general public.
Polyp guideline: diagnosis, treatment, and surveillance for patients with colorectal polyps (2000)

Polyp guideline: diagnosis, treatment, and surveillance for patients with colorectal polyps