gebhart/patrepeval huggingface dataset:
Cloning and DNA-binding properties of a tobacco Ethylene-Insensitive3 (EIN3) homolog (2000)

Ethylene-Insensitive3 (EIN3) is a transcription factor that works in the ethylene signaling pathway in Arabidopsis. We isolated a tobacco cDNA encoding an EIN3 homolog as a sequence-specific DNA-binding protein. The encoded protein TEIL (tobaccoEIN3-like) shares 60% identity in amino acid sequence with EIN3. The DNA-binding domain was localized in the N-terminal half, which shows 92% identity in amino acid sequence with the corresponding region of EIN3, suggesting a conserved function in DNA-binding specificity. TEIL was indeed functionally similar to EIN3 because, like EIN3-overexpressing plants, transgenic Arabidopsis seedlings overexpressing TEIL cDNA exhibited constitutive triple response phenotypes. Random binding site selection analysis revealed that the consensus binding sequence for TEIL is AYGWAYCT, where Y and W represent A or C and A or T, respectively. A reporter plasmid containing the TEIL binding sites showed a 7- to 10-fold higher activation relative to that containing a mutated TEIL-binding sequence in tobacco protoplasts. A further 2- to 3-fold increase in activation was observed when a plasmid for TEIL overproduction was co-transfected, indicating that TEIL is a transcriptional activator. Moreover, nuclear extracts from ethylene-treated leaves showed an increase in DNA-binding activity specific to the TEIL-binding sequence, despite the level of the transcripts being unchanged. These observations suggest that TEIL functions as a transcription activator with a relatively redundant DNA-binding specificity, and its function may be regulated at least in part by modulation of the DNA-binding activity through ethylene signaling.
Adjustable Compensators for Two-beam Interferometers (1962)

When a two-beam interferometer is adjusted to satisfy particular compensation conditions, high-contrast fringes can be obtained when the light source is neither small nor highly monochromatic. In some interferometers a continuous variation of compensation is desirable. Two adjustable compensators are discussed and their application to a lens-testing interferometer is described.
"Harlem Air Shaft": A True Programmatic Composition? (2011)

In 1944, Duke Ellington told a writer from The New Yorker that his composition “Harlem Air Shaft,” recorded four years earlier, was inspired by the myriad sounds heard in the air shaft of a Harlem apartment building (“You hear fights, you smell dinner, you hear people making love…”). Many scholars have contended that Ellington invented this “storyline” after the composition was written. This article addresses the authenticity of “Harlem Air Shaft” as programmatic music. The author finds ample evidence—from unpublished manuscripts, unissued radio broadcasts, analysis of arranging devices and compositional design, and other Ellington testimony—that Ellington did indeed have the sounds and smells of a Harlem air shaft in mind as he wrote the composition.
Boss Tweed's New York (1966)

At the height of his power in New York City, around 1870, William Marcy (Boss) Tweed's hands were everywhere in city government and party politics. His success in looting the city treasury and using the payoff to achieve his objectives earned him a reputation as the classic example of the corrupt municipal boss. Amidst the turbulent political and social conditions of a metropolis in the making, Boss Tweed was, according to Mr. Mandelbaum, the right man at the right time-a master communicator who united the elements in a divided In effect he replaced the good communications which the author argues are essential to democratic decision-making. Mr. Mandelbaum's analysis of the historical situation is a cogent case study in the democratization of American society.
<title>Morphological segmentation of multiprobe fluorescence images for immunophenotyping in melanoma tissue sections</title> (1993)

A fundamental task in studying the action of cancer chemotherapy is to determine the quantity and spatial relationship of tumor-infiltrating lymphocyte populations. Classically this is performed by staining thin tissue sections with antibodies by immunoperoxidase amplification. The staining technique is practically limited to locating a single cell type per tissue section. Full immunophenotyping requires successive staining of serial sections, using statistical analysis to correlate the results. This paper describes a system that brings together multi- parameter fluorescence imaging and morphological segmentation techniques to provide a fast, accurate, and automatic analysis of the lymphocyte infiltrate in tissue sections. With fluorescence techniques a single section can be stained with up to four distinct fluorescently labelled antibodies to determine cell phenotypes. To harness this potential computer vision techniques are required to analyze the images. A routine based on the water shed algorithm has been developed that segments the nuclei image with an accuracy of greater than 90%. By matching the nuclei boundaries to the local peak fluorescence, cell boundary estimates are obtained in the antigen images. By then extracting two measurements from the boundary signal the cells can be classified according to their antigen expression. Determining cell expression of multiple antigens simultaneously provides a more detailed and accurate picture of the tumor infiltrate than single parameter analysis, and increases understanding of the immune response associated with the chemotherapy.
Human B lymphoma cell line producing B cell growth factor. (1985)

Namalva, a human B cell lymphoma line, produced a factor with a molecular weight of approximately 60,000 which enhanced the proliferation of normal activated human B lymphocytes. The factor also enhanced the proliferation of certain B cell lines. It can be distinguished physiologically and biochemically from other lymphokines known to enhance B cell proliferation, namely, interleukin (IL) 1, IL 2, and interferon. The production of B cell growth factor by B cell tumor lines may contribute to their ability to grow autonomously and may reflect an important component of the neoplastic potential of the cell. B cell growth factor produced by tumors may also affect normal cells in vivo.
<title>Particle And Spray Sizing Using Laser Diffraction</title> (1971)

An instrument is described for measuring both particle and droplet size distributions. Based on Fraunhofer diffraction of laser light, the measurement is fast, reliable, and easy to make. Hardcopy results include a characteristic diameter, distribution width, and a 15-segment histogram of the size distribution. Following a brief review of sizing techniques and the importance of measuring size distributions, a technical discussion is presented on the principles of the instrument. Configuration of the instrument is discussed. Five examples of commercial application are presented covering spray and particle samples.
Field‐Dependent Growth Patterns of Metals Electroplated in Nanoporous Alumina Membranes (2004)

Novel core–shell cable structures (see Figure) of metal alloys are described as one application of field-controlled electroplating of metals in anodic aluminum oxide (AAO) templates. At high current density (∼ 20–300 mA/cm2), the electroplating process occurs relatively fast through the surface of the AAO channels to form nanotubes. A second metal is then electroplated at low current density, forming cores inside.
Characterization of adhesive interactions between human endothelial cells and megakaryocytes. (1993)

Cell-cell adhesion is essential for many immunological functions and is believed to be important in the regulation of hematopoiesis. Adhesive interactions between human endothelial cells and megakaryocytes were characterized in vitro using the CMK megakaryocytic cell line as well as marrow megakaryocytes. Although there was no adhesion between unactivated human umbilical vein endothelial cells (HUVEC) and megakaryocytes, treatment of HUVEC with inflammatory cytokines such as IL-1 beta, tumor necrosis factor alpha, INF-gamma, or the phorbol ester phorbol myristate acetate (PMA) resulted in a time- and dose-dependent increase in adhesion. Stimulation of marrow megakaryocytes or CMK cells with the cytokines IL-1 beta, GM-CSF, IL-6, IL-3, or PMA augmented their adhesion to endothelium. Monoclonal antibodies against the LFA-1 subunit of the leukocyte adherence complex CD18 inhibited the binding of marrow megakaryocytes or CMK cells to HUVEC. Adhesion blocking experiments also demonstrated that the VLA-4/VCAM-1 pathway was important for megakaryocyte attachment to HUVEC. Adhesion promoted maturation of megakaryocytic cells as measured by increased expression of glycoproteins GpIb and GpIIb/IIIa and by increased DNA content. These observations suggest that alterations in megakaryocyte adhesion may occur during inflammatory conditions, mediated by certain cytokines, resulting in augmented megakaryocyte maturation.
The collision of trademarks, domain names, and due process in cyberspace (2001)

article Share on The collision of trademarks, domain names, and due process in cyberspace Author: A. Michael Froomkin Univ. of Miami School of Law, Coral Gables, FL Univ. of Miami School of Law, Coral Gables, FLView Profile Authors Info & Claims Communications of the ACMVolume 44Issue 2Feb. 2001 pp 91–97https://doi.org/10.1145/359205.359236Published:01 February 2001Publication History 3citation1,908DownloadsMetricsTotal Citations3Total Downloads1,908Last 12 Months53Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Epidermal growth factor-like, corneal wound healing substance in mouse tears. (1988)

We have identified the presence of a putative corneal wound healing substance in mouse tears, which has a molecular size and immunological properties similar to those of epidermal growth factor (EGF). The substance was capable of binding to EGF receptors in mouse parenchymal cells and this binding was inhibited by anti-EGF serum. The concentration of the EGF-like substance in the tears of male and female mice was estimated to be 79.3 +/- 7.0 (SD) ng/ml and 76.5 +/- 8.1 (SD) ng/ml, respectively, by EGF radioimmunoassay. Removal of the submandibular glands, which produce large amounts of EGF, reduced plasma EGF to an undetectable level and also decreased the concentration of the EGF-like substance in tears to 27.3 +/- 3.9 (SD) ng/ml in male mice and 25.8 +/- 3.7 (SD) ng/ml in female mice. Approximately 50% of sialoadenectomized (submandibular glands removed) male mice with deep corneal wounds developed severe ocular lesions or loss of sight whereas none of normal male mice with similar wounds did. Topical application of EGF to deeply wounded eyes of sialoadenectomized mice eliminated the various complications and restored the healing rate and incidence of recovery to virtually normal levels.
Probabilistic Performance Prediction of Deteriorating Structures Under Different Maintenance Strategies: Condition, Safety and Cost (2003)

This paper describes a probabilistic model for predicting the performance of deteriorating structures under different maintenance strategies. For these structures, the proposed model is used to predict the evolution in time of three performance indicators, namely, condition, safety and cost. The uncertainties associated with these performance indicators are considered. A brief demonstration of the predictive capabilities of the model using a complex data set of random variables characterizing different maintenance strategies for existing concrete bridges is provided.
Mucosal iron transport by rat intestine (1980)

Using highly sensitive 2-site immunoradiometric assays, we examined the relationship between iron absorption from closed intestinal loops and transferrin and ferritin concentrations in isolated duodenal mucosal cells. As in prior studies, mucosal ferritin correlates inversely with iron absorption and directly with body iron stores as measured by the concentration of nonheme iron in liver. Mucosal transferrin, on the other hand, varies directly with both the total mucosal uptake of radioiron and the proportion of this radioiron transferred from the mucosa to the carcass. The highest correlation with iron absorption was observed with the transferrin-ferritin ratio in isolated mucosal cells. These results suggest that there are two functionally distinct iron- binding compartments in the duodenal mucosa. One is a strong compartment, ferritin, and the other is a transport compartment, transferrin. Control of iron absorption by the intestinal mucosa is closely tied to the balance between these two intracellular iron compartments.
The Parables: Their Literary and Existential Dimension (1968)

Book Review| June 01 1968 The Parables: Their Literary and Existential Dimension The Parables: Their Literary and Existential Dimension, Dan Otto Via, Jr.. Lucetta Mowry Lucetta Mowry Search for other works by this author on: This Site Google Journal of Biblical Literature (1968) 87 (2): 216–218. https://doi.org/10.2307/3263357 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Lucetta Mowry; The Parables: Their Literary and Existential Dimension. Journal of Biblical Literature 1 June 1968; 87 (2): 216–218. doi: https://doi.org/10.2307/3263357 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveSBL PressJournal of Biblical Literature Search Advanced Search The text of this article is only available as a PDF. Copyright 1968 Society of Biblical Literature1968 Article PDF first page preview Close Modal You do not currently have access to this content.
Estimation of the Solubility of Metastable Polymorphs: A Critical Review (2018)

Solubility measurements of metastable polymorphs are often complicated by solvent-mediated transformation toward more stable forms. In this review, we first summarize potential experimental methods to estimate the solubility of metastable polymorphs. Then, we discuss a methodology based on a thermodynamic model, which allows solubility predictions from (i) solubility data of the stable form, and (ii) solid-state properties of the stable and metastable forms.
Shedding light on the efficacy of laboratory evolution based on iterative saturation mutagenesis (2008)

Directed evolution has emerged as a general way to engineer essentially any catalytic property of enzymes, but due to the bottleneck imposed by the necessity to screen large libraries of mutants, it is often time-consuming. In order to make this type of protein engineering faster and more efficient than in the past, improved methods for probing protein sequence space need to be developed. This review focuses on recent advances which help to solve the traditional numbers problem in laboratory evolution, as in the directed evolution of enantioselective enzymes. Our contribution in this endeavour is iterative saturation mutagenesis (ISM), which can be used to enhance the enantioselectivity and/or the thermostability of enzymes. The option to use reduced amino acid alphabets as defined by the appropriate codon degeneracies supplements in a crucial way the toolbox in this knowledge-guided approach to laboratory evolution.
Pressure-fixation method of transferring cells from polycarbonate filters to glass slides. (1984)

A technique for the preparation of cytology slides is presented by which cells collected on a polycarbonate membrane filter are transferred to a slide by means of simultaneous pressure and fixation. Using cervical samples as a model, the influence of the filtration rate, filter pore size and duration of pressure application on cell recovery was analyzed. The present version of the preparation procedure uses manual techniques that define the operating characteristics of a fully automated procedure.
Proposal of a voice activity detector for noisereduction (1994)

In some noise reduction techniques, the learning of noise characteristics is required and a voice activity detector (VAD) must be used to determine noise sequences. The VAD proposed is derived from the coherence function computed from two microphones. It is combined with a noise reduction technique and its influence evaluated.
A Study on the Deterioration Process of 22kV Power Cables in Operation (2013)

As an essential part of current industrial society, electric power energy is contantaly increasing in pace with the development of science and technology. In order to meet the demand of electric power, power facilities which take care of the higher voltage and bigger capacity is required. To produce and supply electric power on a sound basis the electric facilities should operate with reliability. To prevent disasters in advance, the high quality facilities should be manufactured, and a constant management should be done. When the power facilities cause accidents, the result is huge national deficits. Since the power facilities play a pivotal role in the key industry of national infrastructures of they should operate for a long time in maintaining a stable state, and the accidents can be prevented in advance. The lifetime of a power cable is considered to be 30 years at the time of manufacture, but in real fields, accidents of cable occur 8-12 years from the start of operation, resulting in a heavy loss of properties. In this paper, we will show that we have found out the cause and process of the deterioration of 22kV cable systems in operation. The result is that the process of deterioration does not follow the Weibull distribution only ; but rather, after the heat deterioration the Weibull distributed deterioration comes, then the cable is destroyed due to the partial discharge resulting from the Weibull distributed deterioration.
Evidence for a Calpeptin-sensitive Protein-tyrosine Phosphatase Upstream of the Small GTPase Rho (1999)

Activation of the thiol protease calpain results in proteolysis of focal adhesion-associated proteins and severing of cytoskeletal-integrin links. We employed a commonly used inhibitor of calpain, calpeptin, to examine a role for this protease in the reorganization of the cytoskeleton under a variety of conditions. Calpeptin induced stress fiber formation in both forskolin-treated REF-52 fibroblasts and serum-starved Swiss 3T3 fibroblasts. Surprisingly, calpeptin was the only calpain inhibitor of several tested with the ability to induce these effects, suggesting that calpeptin may act on targets besides calpain. Here we show that calpeptin inhibits tyrosine phosphatases, enhancing tyrosine phosphorylation particularly of paxillin. Calpeptin preferentially inhibits membrane-associated phosphatase activity. Consistent with this observation, in vitro phosphatase assays using purified glutathione S-transferase fusion proteins demonstrated a preference for the transmembrane protein-tyrosine phosphatase-alpha over the cytosolic protein-tyrosine phosphatase-1B. Furthermore, unlike wide spectrum inhibitors of tyrosine phosphatases such as pervanadate, calpeptin appeared to inhibit a subset of phosphatases. Calpeptin-induced assembly of stress fibers was inhibited by botulinum toxin C3, indicating that calpeptin is acting on a phosphatase upstream of the small GTPase Rho, a protein that controls stress fiber and focal adhesion assembly. Not only does this work reveal that calpeptin is an inhibitor of protein-tyrosine phosphatases, but it suggests that calpeptin will be a valuable tool to identify the phosphatase activity upstream of Rho.
Detection of three kinetic phases in the thermal unfolding of ferricytochrome c (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetection of three kinetic phases in the thermal unfolding of ferricytochrome cTian Y. TsongCite this: Biochemistry 1973, 12, 12, 2209–2214Publication Date (Print):June 1, 1973Publication History Published online1 May 2002Published inissue 1 June 1973https://pubs.acs.org/doi/10.1021/bi00736a005https://doi.org/10.1021/bi00736a005research-articleACS PublicationsRequest reuse permissionsArticle Views217Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: DEALUMINATED FAUJASITE‐TYPE STRUCTURES WITH SILICA ALUMINA RATIOS OVER 100 (1978)

Abstract Durch Behandeln der ultrastabilen Zeolithe USY‐Aoder USY‐Bmit Salzsäure bei 90°C und anschließendes Calcinieren bei 540 bzw. 760°C wurden dealuminierte Faujasit‐Strukturen in Abwesenheit kationischer Al‐Spezies oder anderer ionischer Spezies erhalten.
Regulation of Decidual Cell and Chorion Cell Production of Interleukin‐10 by Purified Bacterial Products (1997)

Our data indicate that both maternal decidual cells and fetally derived chorion cells can produce IL-10 after incubation with bacterial virulence factors. This finding contrasts with our previous findings in which chorion cells did not produce IL-10 after stimulation with IL-1 beta, suggesting that chorion cell production after incubation with bacterial products is independent of IL-1 beta. We speculate that the contribution of anti-inflammatory IL-10 production by human gestational tissues to the inflammatory process in these tissues may be overcome or abrogated by the pro-inflammatory process.
Open-label study of pirfenidone in patients with progressive forms of multiple sclerosis (2003)

Pirfenidone was well tolerated in patients with MS. Patients with primary progressive or secondary progressive MS tolerated the medication and remained clinically stable during the one year of follow up. Placebo-controlled blinded studies are needed to determine clinical effectiveness.
Traumatic Rupture of the Thoracic Aorta (1969)

Rittenhouse, Edward A. M.D.; Dillard, David H. M.D.; Winterscheid, Loren C. M.D.; Merendino, K. Alvin M.D. Author Information
ChemInform Abstract: Highly Regioselective, Lewis Acid‐Free Electrophilic Aromatic Substitution (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.