gebhart/patrepeval huggingface dataset:
CONTINUOUS WAVELET TRANSFORM MODULUS MAXIMA ANALYSIS OF THE ELECTROCARDIOGRAM: BEAT CHARACTERISATION AND BEAT-TO-BEAT MEASUREMENT (2005)

The problem of automatic beat recognition in the ECG is tackled using continuous wavelet transform modulus maxima (CWTMM). Features within a variety of ECG signals can be shown to correspond to various morphologies in the CWTMM domain. This domain has an easy interpretation and offers a useful tool for the automatic characterization of the different components observed in the ECG in health and disease. As an application of this enhanced time-frequency analysis technique for ECG signals, an R-wave detector is developed and tested using patient signals recorded in the Coronary Care Unit of the Royal Infirmary of Edinburgh (attaining a sensitivity of 99.53% and a positive predictive value of 99.73%) and with the MIT/BIH database (attaining a sensitivity of 99.70% and a positive predictive value of 99.68%).
REPTILES OF THE NEVADA TEST SITE (1963)

Results are reported from an ecological study of reptiles of the Nevada Test Site. Twenty-nine species of reptiles were found, including one tortoise, thirteen lizards, ard fifteen snakes. The effects of nuclear detonations were apparent on the distribution of reptiles near ground zero. The degree of disturbance decreased outward from ground zero. Food and suitable habitat were the main factors affecting the distribution of reptiles. (C.H.)
Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody (2016)

Nesprin-1-α2 mRNA and protein expression is switched on during myogenesis, alongside other known markers of muscle differentiation. The results show that nesprin-1-α2 is dynamically controlled and may be involved in some process occurring during early myofibre formation, such as re-positioning of nuclei.
Long-term impairment of endothelium-dependent relaxations to aggregating platelets after reperfusion injury in canine coronary arteries. (1990)

Experiments were designed and performed to determine whether endothelial function remained chronically impaired after coronary artery reperfusion. Canine left anterior descending coronary arteries were exposed to ischemia (60 minutes) followed by reperfusion (12 weeks). Rings (3-4 mm wide) of the reperfused artery and of normal left circumflex (control) coronary artery segments were suspended in organ chambers containing physiological saline solution (37 degrees C, gassed with 95% O2-5% CO2) for isometric force measurement. Endothelium-independent contractions to KCl or prostaglandin F2 alpha and endothelium-independent relaxations to nitric oxide or isoproterenol were comparable in control and chronically reperfused arteries. However, chronically reperfused coronary arteries exhibited impaired endothelium-dependent relaxations to aggregating platelets. In addition, the reperfused coronary arteries exhibited impaired endothelium-dependent relaxations to the platelet-derived compounds adenosine diphosphate, serotonin, and thrombin. However, the endothelium-dependent relaxations to acetylcholine were comparable between control and reperfused arteries. Thus, after 12 weeks of reperfusion, previously occluded coronary arteries exhibited a selective impairment of endothelium-dependent relaxation evoked by aggregating platelets. In vivo, this phenomenon could favor platelet adhesion, aggregation, and platelet-induced contraction of coronary smooth muscle and thus facilitate ischemic events such as vasospasm and coronary thrombosis.
Prostate-derived Ets Factor Is Overexpressed in Serous Epithelial Ovarian Tumors (2006)

The frequent overexpression of prostate-derived Ets factor (PDEF) mRNA in ovarian cancer has been previously reported. The aim of this study was to evaluate PDEF protein expression in ovarian cancer and how this expression might vary at different stages of epithelial ovarian tumors in comparison to normal ovary. A new rabbit polyclonal antibody to PDEF was prepared, and immunohistochemistry was performed on tissue sections from 12 normal ovaries, 10 cases of benign serous cystadenoma, 17 cases of low malignant potential tumor, 19 cases of stage 1, and 15 cases of advanced stage primary epithelial (serous) ovarian carcinomas and their peritoneal metastases. Expression levels were assessed based on the percentage of positively staining cells and the intensity of staining. All 12 normal ovary and 10 benign serous cystadenoma cases were negative for PDEF expression. In contrast, 6 of 17 (35%) low malignant potential tumors, 5 of 19 (27%) stage 1, and 5 of 15 (33%) advanced stage ovarian tumors stained positive for PDEF expression. Together, these results show frequent overexpression of PDEF protein in epithelial ovarian tumors and its lack of expression in normal ovary and cystadenomas, and this supports a role for PDEF in ovarian tumorigenesis. Furthermore, these results suggest that PDEF is a potential marker and target in ovarian cancer.
MIXED CONVECTION IN A HORIZONTAL SQUARE PACKED-SPHERE CHANNEL UNDER AXIALLY UNIFORM HEATING PERIPHERALLY UNIFORM WALL TEMPERATURE (2004)

This study ignores the nonlinear inertia terms of non-Darcian mixed convection in a horizontal packed-sphere (stainless sphere and water) channel under uniform axial heating and peripherally uniform wall temperature. The important characteristics of non-Darcian convection are the no-slip boundary, the flow inertia, the channeling effect and the thermal dispersion effect. The ranges of the Rayleigh number Ra = 0 − 3 × and the Peclet number Pe = 10 − 200 are used in this study. A secondary flow, induced by the buoyancy effect, occurs when Ra is high and Pe is low. However, as Pe increases, the buoyancy effect is suppressed because thermal dispersion dominates. Moreover, simulation results agree closely with experimental data in the fully developed region.
Integrated real-time and run-to-run control of etch depth in reactive ion etching (1997)

Reactive Ion Etching (RIE) is a common process step in semiconductor manufacturing, yet the underlying mechanisms remain poorly understood. Our goal is to reduce the variance of etch characteristics by integrating real-time and run-to-run control of plasma and process variables. The run to run controller suggests plasma variable set-points based on the wafer characteristics of the previous run. The real-time controller maintains the suggested plasma variables by manipulating the process inputs during the etch. We have demonstrated the integrated control architecture for rejecting oxygen and loading disturbances in an Applied 8300 Hexode Reactor during a polysilicon etch.
Large‐Area 2D Gold Nanorod Arrays Assembled on Block Copolymer Templates (2012)

Various large-area 2D gold nanorod arrays are achieved on plasma-etched block copolymer templates. With the help of capillary forces, aqueous gold nanorods assembled on the templates show good position selectivity and high coverage of the grooves. Furthermore, these nanorod arrays can transform into gold nanowires by a post-etching process.
Successful treatment of superficial pyoderma gangrenosum associated with hidradenitis suppurativa with adalimumab (2010)

Pyoderma gangrenosum (PG) and hidradenitis suppurativa (HS) are chronic inflammatory dermatoses that can be a challenge to treat. A role for TNF-alpha in their pathogenesis has been postulated in the literature. A therapeutic benefit of infliximab has been reported in recalcitrant cases of both conditions. To date, there is less evidence about the use of adalimumab for these conditions. We report a patient with severe superficial PG on a background of HS, which responded to adalumimab therapy after failure of infliximab therapy.
High‐resolution MR imaging of human arteries (1995)

The authors studied the magnetic resonance (MR) imaging appearance of excised human arteries and correlated these findings with those from histologic sections obtained in corresponding planes. Imaging was performed with a 1.5-T clinical imager modified with an additional gradient insert capable of a 30 mT/m gradient. High-resolution images of arteries obtained at autopsy indicated that the medial and adventitial layers could be distinguished and that T2-weighted sequences offered superior contrast. Intimal thickening could be detected at a relatively early stage as a long T2 rim on the luminal surface of the artery. Atherosclerotic plaque was found to have MR properties similar to those of intimal thickening, although necrotic regions within plaque had low signal intensity. Fat suppression sequences did not significantly alter the appearance of atherosclerotic plaque. Calcified plaque produced effects ranging from slight signal loss to signal void. MR imaging findings correlated reliably with the tissue types indicated by histologic analysis.
Linker Length Matters, Fynomer-Fc Fusion with an Optimized Linker Displaying Picomolar IL-17A Inhibition Potency (2014)

Fynomers are small binding proteins derived from the human Fyn SH3 domain. Using phage display technology, Fynomers were generated inhibiting the activity of the proinflammatory cytokine interleukin-17A (IL-17A). One specific Fynomer called 2C1 inhibited human IL-17A in vitro with an IC50 value of 2.2 nm. Interestingly, when 2C1 was genetically fused to the Fc part of a human antibody via four different amino acid linkers to yield bivalent IL-17A binding proteins (each linker differed in length), the 2C1-Fc fusion protein with the longest linker displayed the most potent inhibitory activity. It blocked homodimeric IL-17A with an IC50 value of 21 pm, which corresponds to a hundredfold improved IC50 value as compared to the value obtained with monovalent Fynomer 2C1. In contrast, the 2C1-Fc fusion with the shortest linker showed only an ∼8-fold improved IC50 value of 260 pm. Furthermore, in a mouse model of acute inflammation, we have shown that the most potent 2C1-Fc fusion protein is able to efficiently inhibit IL-17A in vivo. With their suitable biophysical properties, Fynomer-Fc fusion proteins represent new drug candidates for the treatment of IL-17A mediated inflammatory conditions such as psoriasis, psoriatic arthritis, or rheumatoid arthritis.
A Simple Region Descriptor Based on Object Area per Scan Line (2010)

In the field of image processing, identifying object is based on appropriately chosen descriptors. The proper choice of descriptors in pattern recognition is the most sensitive criteria as small misjudgments may lead to wrong identification. There have been several algorithms proposed and worked in this field. Here, the idea is to identify the objects in an uncomplicated method while being computationally efficient. This paper is based on identifying the patterns of objects / polygons based on the recording area of the objects per line scan. The descriptors here are invariant to translation and become invariant to scaling after normalization.
Motion compensated reconstruction for myocardial perfusion MRI (2012)

Background Classical acceleration schemes for myocardial perfusion MRI like view sharing, k-t BLAST [Tsao et al. ‘03] are sensitive to motion artifacts which could arise in data with inconsistent gating and/or breathing motion. A natural approach to be robust to this is to estimate the motion and compensate for it during the recovery; to this end we proposed a novel joint motion estimation and reconstruction scheme in [Lingala et al. ‘11]. One goal of this work is to further validate it by recovering such data at considerable accelerations (R). In a 2nd goal, we apply it to recover images acquired with an ungated protocol [DiBella et al. ‘11]. This obtains data at a rapid rate without any gating to provide robustness to beat-beat variability. It also offers a high temporal resolution (~50ms), which ensures maximal information is obtained during the brief first pass. This resolution also means the cardiac motion is captured, akin to cine imaging. Here, we aim to benefit the reconstructions by compensating for this motion. We show its utility by comparisons with standard gridding reconstruction (GR) and sliding window (SW) algorithm.
A Dynamic Vocabulary Speech Recognizer Using Real-Time, Associative-Based Learning (2006)

Conventional speech recognizers employ a training phase during which many of their parameters are configured - including vocabulary selection, feature selection, and decision mechanism tailoring to these selections. After this stage during normal operation, these traditional recognizers do not significantly alter any of these parameters. Conversely this work draws heavily on high level human thought patterns and speech perception to outline a set of precepts to eliminate this training phase and instead opt to perform all its tasks during the normal operation. A feature space model is discussed to establish a set of necessary and sufficient conditions to guide real-time feature selection. Detailed implementation and preliminary results are also discussed. These results indicate that benefits of this approach can be seen in increased speech recognizer adaptability while still retaining competitive recognition rates in controlled environments. Thus this can accommodate such changes as varying vocabularies, class migration, and new speakers.
Critical Review of Pd-Based Catalytic Treatment of Priority Contaminants in Water (2012)

Catalytic reduction of water contaminants using palladium (Pd)-based catalysts and hydrogen gas as a reductant has been extensively studied at the bench-scale, but due to technical challenges it has only been limitedly applied at the field-scale. To motivate research that can overcome these technical challenges, this review critically analyzes the published research in the area of Pd-based catalytic reduction of priority drinking water contaminants (i.e., halogenated organics, oxyanions, and nitrosamines), and identifies key research areas that should be addressed. Specifically, the review summarizes the state of knowledge related to (1) proposed reaction pathways for important classes of contaminants, (2) rates of contaminant reduction with different catalyst formulations, (3) long-term sustainability of catalyst activity with respect to natural water foulants and regeneration strategies, and (4) technology applications. Critical barriers hindering implementation of the technology are related to catalyst activity (for some contaminants), stability, fouling, and regeneration. New developments overcoming these limitations will be needed for more extensive field-scale application of this technology.
Neurological Sequelae Resulting from Encephalitic Alphavirus Infection (2016)

The recent surge in viral clinical cases and associated neurological deficits have reminded us that viral infections can lead to detrimental, long-term effects, termed sequelae, in survivors. Alphaviruses are enveloped, single-stranded positive-sense RNA viruses in the Togaviridae family. Transmission of alphaviruses between and within species occurs mainly via the bite of an infected mosquito bite, giving alphaviruses a place among arboviruses, or arthropod-borne viruses. Alphaviruses are found throughout the world and typically cause arthralgic or encephalitic disease in infected humans. Originally detected in the 1930s, today the major encephalitic viruses include Venezuelan, Western, and Eastern equine encephalitis viruses (VEEV, WEEV, and EEEV, respectively). VEEV, WEEV, and EEEV are endemic to the Americas and are important human pathogens, leading to thousands of human infections each year. Despite awareness of these viruses for nearly 100 years, we possess little mechanistic understanding regarding the complications (sequelae) that emerge after resolution of acute infection. Neurological sequelae are those complications involving damage to the central nervous system that results in cognitive, sensory, or motor deficits that may also manifest as emotional instability and seizures in the most severe cases. This article serves to provide an overview of clinical cases documented in the past century as well as a summary of the reported neurological sequelae due to VEEV, WEEV, and EEEV infection. We conclude with a treatise on the utility of, and practical considerations for animal models applied to the problem of neurological sequelae of viral encephalopathies in order to decipher mechanisms and interventional strategies.
Metachromins A and B, novel antineoplastic sesquiterpenoids from the Okinawan sponge Hippospongia cf. metachromia (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetachromins A and B, novel antineoplastic sesquiterpenoids from the Okinawan sponge Hippospongia cf. metachromiaMasami Ishibashi, Yasushi Ohizumi, Jie Fei Cheng, Hideshi Nakamura, Yoshimasa Hirata, Takuma Sasaki, and Junichi KobayashiCite this: J. Org. Chem. 1988, 53, 12, 2855–2858Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/jo00247a041https://doi.org/10.1021/jo00247a041research-articleACS PublicationsRequest reuse permissionsArticle Views336Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Carbon−Silicon Hyperconjugation and Strain-Enhanced Hyperconjugation:  Structures of<i>N</i>-Methyl 2- and 4-<i>tert</i>-Butyldimethylsilylmethyl Pyridinium Cations (2007)

NBO analysis of the interaction of trialkylsilylmethyl substituents with the electron-deficient pyridinium cation suggests that hyperconjugation is strongest at the 2-position. Crystal structures of 2- and 4-tert-butyldimethylsilylmethyl-substituted N-methyl pyridinium cations 2d and 3d however do not reveal any significant structural differences arising from differences in hyperconjugation at the 2- and 4-positions. Previously observed differences in the triisopropylsilyl derivatives 2c and 3c are proposed to arise as a result of strain-enhanced hyperconjugation.
Connection-based communication in dynamic networks (1992)

We analyze and improve the fault tolerance of practical, efficient end to end communication schemes.
A 0.3&#x223C;17.2GHz frequency divider with capacitive degeneration in 130nm CMOS (2012)

A high speed and wide range CML frequency divider was realized in 130nm CMOS by using the capacitive degeneration technique. Varactors are placed at the source of the cross-coupled transistors to improve the self-oscillation frequency of dividers. With the tuning of varactors and PMOS load, wide range can be realized. When working at 1.2V supply voltage, a maximum locking range of 16.9 GHz, from the incident frequency 0.3 to 17.2 GHz, is achieved at the incident power of 0 dBm. The frequency divider consumes a static current of 3.6 mA.
An Antibody with Specificity for Surfactant Protein C Precursors: Identification of Pro-SP-C in Rat Lung (1992)

Surfactant protein C (SP-C) is a lung-specific, hydrophobic peptide found in organic extracts of pulmonary surfactant. Alveolar SP-C (3.5 kD) is produced from proteolytic cleavage of a larger precursor molecule (pro-SP-C; 21 kD). While SP-C is synthesized by type II cells, the pathways for processing and secretion have remained elusive due, in part, to the lack of monospecific antibodies against SP-C or its precursors. This report describes production and characterization of a new antibody directed against pro-SP-C epitopes. Polyclonal antisera (anti-CPRO-SP-C) was prepared using a synthetic peptide corresponding to a portion of rat SP-C cDNA sequence (Ile26-Ser72). This contained amino acids 3-35 of mature SP-C plus additional C-terminal residues (His59-Ser72). On Western blots, anti-CPRO-SP-C competitively reacted to CPRO-SP-C but not to mature SP-C. Immunoblots of in vitro synthesized pro-SP-C confirmed that the antisera also recognized native protein. Immunocytochemistry with anti-CPRO-SP-C demonstrated staining for pro-SP-C peptides in isolated type II cells as well as in alveolar epithelial cells of rat lung sections. Pro-SP-C preferentially co-localized to cells that stained positive for Maclura pomifera antigen. Anti-CPRO-SP-C staining was not observed in lung interstitium, pulmonary vasculature, or several control tissues (brain, heart, and liver were negative). Western blotting of subcellular fractions demonstrated pro-SP-C peptides in plasma membrane (20 kD) and microsomal (20 and 21 kD) fractions with a 16 kD peptide present in lamellar bodies. No pro-SP-C peptides were detected in purified surfactant. These results demonstrate the use of a synthetic peptide to generate specific antiserum against more hydrophilic domains of pro-SP-C sequences and confirm that SP-C propeptides are unique to the lung.
Phosphorylation of the 1,25-dihydroxyvitamin D3 receptor. A primary event in 1,25-dihydroxyvitamin D3 action. (1990)

1,25-Dihydroxyvitamin D3 is believed to mediate the regulation of calcium metabolism by a steroid hormone receptor mechanism. We now demonstrate that phosphorylation of the 1,25-dihydroxyvitamin D3 receptor occurs rapidly in embryonic chick duodenal organ culture in response to 1,25-dihydroxyvitamin D3. Phosphorylation of the receptor is strongly induced within 1 h by 1,25-dihydroxyvitamin D3 and occurs prior to the initiation of calcium uptake or induction of calcium-binding protein in this system. Phosphorylation is not affected by inhibition of protein synthesis by cycloheximide. Since chick duodenal organ culture is a vitamin D-responsive system that closely parallels in vivo rachitic chicken intestine, the occurrence of receptor phosphorylation in response to 1,25-dihydroxyvitamin D3 strongly suggests that it is a physiologically relevant event. In addition, since it occurs prior to the other responses to 1,25-dihydroxyvitamin D3, it appears possible that phosphorylation may play a significant role in the 1,25-dihydroxyvitamin D3 regulation of transcription in the intestine.
T lymphocyte tissue culture lines produced by cell hybridization (1977)

This study describes the generation of permanent T cell tissue culture lines by cell fusion techniques. The AKR strain-derived T cell tumor BW 5147 was hybridized in the presence of polyethylene glycol with various T cell populations isolated from antigen-sensitized mice. Surface analysis of resulting hybrid cell lines showed expression of both Thy-1.2 and H-2 antigens which are characteristic for the lymphocyte used for fusion. In contrast, in hybrids derived from spleen cells neither expression of Ig nor of B cell-typicyl Ia determinants was found suggesting either preferential hybridization of BW 5147 cells with T lymphocytes or extinction of B cell markers in hybrid cells. These hybrid lines which may display the immunological properties of the T cell population chosen are presently investigated for their antigen reactivity.