gebhart/patrepeval huggingface dataset:
A chip-based silicon nitride platform for mid-infrared nonlinear photonics (2017)

We developed a chip-based silicon nitride platform with thick waveguides (> 2 mm) that overcomes the usual fabrication limitation. We demonstrate both microresonator frequency comb generation at 2:5 mm and supercontinuum generation extending beyond 4:0 mm in this platform.
Design optimization for asymmetrical ZVS-PWM zeta converter (2003)

In this paper, a new soft-switching Zeta converter with an asymmetrical pulsewidth modulation (PWM) control is proposed. The proposed Zeta converter has the features of constant frequency operation, zero voltage switching (ZVS), and low voltage stress on the active switches. Moreover, it can achieve high power density, high efficiency, low switching loss, and low component count, which make converter operation at low to medium power level feasible. Operational principle of the Zeta converter is presented in detail, and a specific example is designed and implemented to verify its feasibility.
Efficient and Practical Ag-Catalyzed Cycloadditions between Arylimines and the Danishefsky Diene (2003)

An efficient Ag-catalyzed method for asymmetric addition of the Danishefsky diene to various aryl imines to afford cycloadducts in > or =89% ee and > or =85% isolated yield is reported. Reactions are effected with 0.1-1 mol % catalyst (4 degrees C), and the chiral ligand is readily prepared from commercially available materials, including the inexpensive i-Leu. These catalytic asymmetric cycloadditions can be carried out without the use of solvent or with undistilled THF in air. A first generation supported chiral catalyst that effectively promotes the cycloaddition reaction and can be recycled (five cycles) is described.
Relationship between Lipophilicities of 1,4-Dihydropyridine Derivatives and Pharmacokinetic Interaction Strengths with Grapefruit Juice (2008)

It is well known fact that the strengths of drug interactions with grapefruit juice (GFJ) differ greatly depending on the 1,4-dihydropyridine calcium channel antagonist (DHP) used. However, there are no available data on the relationship between interactions with GFJ and its physicochemical attributes. Therefore we endeavored to study the correlation between calculated logP values, indicating lipophilicity, from chemical structures of DHPs as well as water diffusion, molecular volume, molecular polarization, molecular density, refractive index, topologic polar surface area, and calculated molar refractivity. Thirteen forms of DHP, amlodipine, azelnidipine, benidipine, cilnidipine, efonidipine, felodipine, manidipine, nicardipine, nifedipine, nimodipine, nisoldipine, nitrendipine, and pranidipine were analyzed due to clinical trials performed with GFJ and these agents. The pharmacokinetic interaction strengths were defined in common logarithmic values of increasing ratios of area under the plasma concentration-time curve (AUC) with GFJ intake compared with controls. Physicochemical properties including three categories of predicted logP values were calculated from the structures of DHPs and their estimated relationship with the interactions. As a result, the logP values indicated significant positive correlations with the interaction strengths. This finding suggests that lipophilicity is an important factor in the strengths of pharmacokinetic interactions of DHPs with GFJ intake.
Rearrangement of Epoxynitriles:  A Convenient Homologation of Acyclic and Cyclic Ketones to Carboxylic Acids (2002)

A convenient two-step homologation of both aliphatic and aromatic ketones to the corresponding carboxylic acid has been developed. First ketones were converted to epoxynitriles with the Darzens reaction. Second, a Lewis acid mediated rearrangement of these epoxynitriles with lithium bromide was achieved to give homologated secondary alkanoic acids (as well as aryl-alkanoic) in good yields. The mechanism and the scope of the rearrangement reaction were investigated. This strategy constitutes a two-step homologation of ketones to secondary carboxylic acids.
The Free-radical Catalyzed Addition of Alcohols and Aldehydes to Perfluoroölefins<sup>1</sup> (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Free-radical Catalyzed Addition of Alcohols and Aldehydes to Perfluoroölefins1J. D. LaZerte and R. J. KosharCite this: J. Am. Chem. Soc. 1955, 77, 4, 910–914Publication Date (Print):February 1, 1955Publication History Published online1 May 2002Published inissue 1 February 1955https://pubs.acs.org/doi/10.1021/ja01609a033https://doi.org/10.1021/ja01609a033research-articleACS PublicationsRequest reuse permissionsArticle Views457Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pathways of Chlorinated Ethylene and Chlorinated Acetylene Reaction with Zn(0) (1998)

To successfully design treatment systems relying on reactions of chlorocarbons with zero-valent metals, information is needed concerning the kinetics and pathways through which transformations occur. In this study, pathways of chlorinated ethylene reaction with Zn(0) have been elucidated through batch experiments. Data for parent compound disappearance and product appearance were fit to pseudo-first-order rate expressions in order to develop a complete kinetic model. Results indicate that reductive β-elimination plays an important role, accounting for 15% of tetrachloroethylene (PCE), 30% of trichloroethylene (TCE), 85% of cis-dichloroethylene (cis-DCE), and 95% of trans-dichloroethylene (trans-DCE) reaction. The fraction of PCE, TCE, trans-DCE, and cis-DCE transformation that occurs via reductive elimination increases as the two-electron reduction potential (E2) for this reaction becomes more favorable relative to hydrogenolysis. In the case of PCE and TCE, reductive elimination gives rise to chlorinated acetylenes. Chloroacetylene and dichloroacetylene were synthesized and found to react rapidly with zinc, displaying products consistent with both hydrogenolysis and reduction of the triple bond. Surface area-normalized rate constants (kSA) for chlorinated ethylene disappearance correlate well with both one-electron (E1) and two-electron (E2) reduction potentials for the appropriate reactions. Correlation with E2 allows prediction of the distribution of reaction products as well as the rate of disappearance of the parent compound.
Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects (2018)

Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and the ability to invasion and deportation are discussed. These features are considered from a perspective that determines the placental material as a unique source for regenerative cell therapies and a lesson for immunological tolerance. A historical overview of clinical applications of placental extracts, cells, and tissue components is described. Empirically accumulated data are summarized and compared with modern research. Furthermore, we define scopes and outlooks of application of placental cells and tissues in the rapidly progressing field of regenerative medicine.
Flux-Flow-Type Josephson Linear Amplifier with Large Gain and Wide Linear Range (1985)

A linear amplifier using a flux-flow phenomenon in a long Josephson junction has been designed and tested by connecting a load resistance. The present experiment has demonstrated that a current gain of 500/ W s (1/µm) is obtained for the load resistance of 9 mΩ when an input signal is applied with a control line of width W s (µm). An equivalent circuit of the amplifier has also been presented, which shows that the device is most suitable for current amplification with large gain in low impedance circuits.
Temperature dependent gain and noise characteristics of a 1480 nm-pumped erbium-doped fibre amplifier (1990)

The gain of a 1480 nm pumped erbium-doped fibre amplifier has been measured over the temperature range −40°C to 60°C. The characteristics can be modelled using emission and absorption cross-section data determined for this temperature range. The temperature dependence of the gain spectrum and noise figure are also predicted.
Content-based filtering system for music data (2004)

Recommender systems, which recommend appropriate information to users from enormous amount of information, are becoming popular. There are two methods to realize recommender systems. One is content-based filtering, and the other is collaborative filtering. Many systems using the former method deal with text data, and few systems deal with music data. This paper proposes a content-based filtering system that targets music data in MIDI format. First, we analyze characteristics of feature parameters about music data in MIDI format. Then we propose a filtering method based on the above feature parameters. Finally, we build a prototype system with standard technology of the Internet.
Compressing encrypted data: A permutation approach (2012)

In a system where it is necessary to perform both encryption and lossy compression, the conventional way is to compress first and then encrypt the compressed data. Furthermore, this separation proves to be optimal. In certain applications where sensitive information should be protected as early as possible, it is preferable to perform encryption first and then compress the encrypted data. We call this the reversed system. Johnson et al. proposed an achievability scheme for the reversed system that utilizes modulo-sum encryption followed by compression using Wyner-Ziv distributed source coding with side information. However, the scheme requires more compression rate and secrecy key rate than the conventional system that first compresses and then encrypts. In this paper, we propose a new achievability scheme for the reversed system where encryption is done using a permutation cipher and then the encrypted data is compressed using the optimal rate-distortion code. The proposed scheme can achieve the optimal compression rate and secret key rate, and therefore shows that reversing the order of encryption and compression does not lead to performance loss of an encryption-compression system.
Serving Christ in the City (2016)

Can Christians maintain their spirituality and carry out the gospel commission in one of today’s urban centers? Most western cities are dominated by secularism and lifestyles that are anything but Christian. They are case studies for the idea of a post-Christian world. Disciple making in an urban center requires connecting with people, engaging with the culture, serving sacrificially, living faith publicly, and challenging reasoning. Being present in the city with any meaningful level of relational engagement without being offensive or dismissed as being religious oddities is a difficult challenge in post-Christian culture. Some conservative Christians believe this to be impossible. But it is simply not accurate to say that spirituality is dead in the secular city. It is organized religion that is threatened. Spirituality is alive. However, there are new gods usurping the primacy of Christian faith. Those gods can be thought of in terms such as opportunity, wealth, technology, or art. Spiritual ideas and dialogue still exist. But the new spirituality of the Western developed world has little regard for organized religion.
Noise reduction by torque ripple suppression in brushless DC motor (2002)

The acoustic noise of a brushless DC motor is thought to be partly due to torque ripple. This paper examines, both analytically and experimentally, the effect of ripple reduction on the noise reduction. To realize the torque ripple reduction an overlapping of phase current is utilized here. In the simulation, motor parameters such as inductance, and counter EMF are derived from two dimensional FEM of magnetic field analysis. The characteristics of currents, voltages and torque of the motor are analyzed by using our own circuit simulator. It is clarified that the current overlapping is useful for the torque ripple reduction and noise reduction.
Zenso Arakawa et al. v. Clark, Atty. Gen., et al. (1949)

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Spectral Domain B-spline Identification in Acoustic Echo Cancellation (2006)

Spectral domain B-spline identification is proposed for acoustic echo cancellation. Two approaches are considered. The first is based on the solution of normal equations; we describe an efficient technique for such a solution, which benefits from the sparseness of the system matrix due to B-splines. The second approach is based on using local splines, enabling further simplification. We also show how the proposed techniques can be used for efficient double-talk detection. The echo cancellation performance and complexity of the proposed techniques are compared with that of a low-complexity cross-spectral technique and the affine projection (AP) algorithm possessing high cancellation performance. The B-spline identification allows cancellation performance comparable with that of the AP algorithm and complexity close to that of the cross-spectral algorithm.
A utilização de retalho composto de pele e tecido mamário na reparação de área cruenta resultante da deiscência de esternotomia em cirurgia cardíaca (2004)

OBJETIVO: Descrever nova técnica para a reparação de áreas cruentas resultantes de infecção e deiscência de esternotomia na cirurgia cardíaca em seis mulheres que, além de área cruenta extensa na região esternal, haviam sido submetidas a uma primeira reintervenção com recidiva. MÉTODOS: É descrita a técnica cirúrgica utilizada baseada em retalho triangular composto de pele e tecido mamário com base no sulco inframamário inferior, transposto para a área cruenta a fim fornecer uma cobertura de tecido bem vascularizado. RESULTADOS: São discutidos os diversos tratamentos da fase aguda e também de reconstrução nas deiscências de região esternal. CONCLUSÃO: Este retalho preenche as necessidades em relação às dimensões da perda de tecido da área cruenta além de fornecer uma maior proteção contra infecção a uma área que, pela deiscência ocorrida, permaneceu por certo tempo exposta.
Solubility parameters of poly(4‐substituted α‐acetoxystyrenes) and alternating copolymers of vinylidene cyanide with substituted styrenes (1994)

Abstract The δ solubility parameters of three families of polymers have been determined by two calculation methods suggested by Small and Hoy. Hansen's model has also been used to assess δ and its components δ d 0 , δ p 0 , and δ h 0 , so as to obtain more information on the intensity of the forces between the chain segments. Knowing the microstructure, the tacticity, and the thermal behavior of the copolymers has made it possible to explain both the different values of δ and the progression of solubility areas. Using Teas' method has made it possible to visualize on the same map the influence of the forces of interaction. This representation shows that the presence of the vinylidene cyanide unit in styrenic chains implies an increase of δ p and a decrease of δ d , whereas δ h remains roughly constant for the corresponding homopolymer. © 1994 John Wiley & Sons, Inc.
SCH28080, a K<sup>+</sup>-Competitive Inhibitor of the Gastric H,K-ATPase, Binds Near the M5−6 Luminal Loop, Preventing K<sup>+</sup> Access to the Ion Binding Domain (2002)

Inhibition of the gastric H,K-ATPase by the imidazo[1,2-alpha]pyridine, SCH28080, is strictly competitive with respect to K+ or its surrogate, NH4+. The inhibitory kinetics [V(max), K(m,app)(NH4+), K(i)(SCH28080), and competitive, mixed, or noncompetitive] of mutants can define the inhibitor binding domain and the route to the ion binding region within M4-6. While mutations Y799F, Y802F, I803L, S806N, V807I (M5), L811V (M5-6), Y928H (M8), and Q905N (M7-8) had no effect on inhibitor kinetics, mutations P798C, Y802L, P810A, P810G, C813A or -S, I814V or -F, F818C, T823V (M5, M5-6, and M6), E914Q, F917Y, G918E, T929L, and F932L (M7-8 and M8) reduced the affinity for SCH28080 up to 10-fold without affecting the nature of the kinetics. In contrast, the L809F substitution in the loop between M5 and M6 resulted in an approximately 100-fold decrease in inhibitor affinity, and substitutions L809V, I816L, Y925F, and M937V (M5-6, M6, and M8) reduced the inhibitor affinity by 10-fold, all resulting in noncompetitive kinetics. The mutants L811F, Y922I, and I940A also reduced the inhibitor affinity up to 10-fold but resulted in mixed inhibition. The mutations I819L, Q923V, and Y925A also gave mixed inhibition but without a change in inhibitor affinity. These data, and the 9-fold loss of SCH28080 affinity in the C813T mutant, suggest that the binding domain for SCH28080 contains the surface between L809 in the M5-6 loop and C813 at the luminal end of M6, approximately two helical turns down from the ion binding region, where it blocks the normal ion access pathway. On the basis of a model of the Ca-ATPase in the E2 conformation (PDB entry 1kju), the mutants that change the nature of the kinetics are arranged on one side of M8 and on the adjacent side of the M5-6 loop and M6 itself. This suggests that mutations in this region modify the enzyme structure so that K+ can access the ion binding domain even with SCH28080 bound.
Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart. (1994)

Fatty acid oxidation rapidly increases in the rabbit heart following birth. By inhibiting carnitine palmitoyltransferase 1 (CPT1), malonyl-CoA is a potent regulator of fatty acid oxidation in the heart. We therefore addressed the hypothesis that a decrease in acetyl-CoA carboxylase (ACC) activity and/or malonyl-CoA inhibition of CPT1 could account for the increase in the ability of the heart to oxidize fatty acids following birth. ACC activity and expression, malonyl-CoA levels, and mitochondrial CPT1 activity were measured in hearts from 1-day, 7-day, and 6-week-old rabbits. CPT1 activity and sensitivity to malonyl-CoA inhibition did not differ between 1-day, 7-day, or 6-week hearts (the IC50 for malonyl-CoA was 32.0 +/- 1.5, 36.0 +/- 0.3, and 36.3 nM, respectively). Western blot analysis with streptavidin showed that all hearts expressed similar amounts of both a 265-kDa (ACC-265) and 280-kDa isoform (ACC-280) of ACC. A progressive and significant decrease in malonyl-CoA levels was seen in 1-day, 7-day, and 6-week hearts (47 +/- 2, 40 +/- 2, and 26 +/- 2 nmol/g dry weight, respectively), paralleling a decline in ACC activity. We hypothesized that these developmental changes could be due to changes in hormonal regulation of cardiac ACC in the postnatal period. In isolated hearts from 1-day-old rabbits, the fatty acid oxidation rate was 9.01 +/- 1.10 nmol.g dry weight-1.min-1. Glucagon (1 ng/ml) did not alter this rate (11.03 +/- 1.42 nmol.g dry weight-1.min-1), but insulin (100 microunits/ml) resulted in a significant decrease in rate (4.81 +/- 0.82 nmol.g dry weight-1.min-1). ACC activity was markedly elevated in 1-day-old hearts perfused with insulin compared to control hearts or glucagon perfused hearts (0.415 +/- 0.052, 0.095 +/- 0.018, and 0.133 +/- 0.013 nmol of malonyl-CoA produced.g dry weight-1.min-1, respectively). Malonyl-CoA levels were also markedly elevated in 1-day hearts perfused with insulin (123.0 +/- 8.3, 2.0 +/- 0.4, and 1.8 +/- 0.6 nmol/g dry weight in insulin, control, and glucagon hearts, respectively). In 7-day-old rabbit hearts, the basal fatty acid oxidation rate had increased to 24.5 +/- 4.8 nmol.mg-1.min-1. In contrast to the 1-day-old hearts, insulin had no significant effect on fatty acid oxidation, although glucagon resulted in a significant increase in rates (38.9 +/- 12.2 and 80.7 +/- 9.1 nmol.g dry weight-1.min-1, respectively).(ABSTRACT TRUNCATED AT 400 WORDS)
Epoxy resin allergy from microscopy immersion oil (1999)

A bacteriology technical officer presented with episodes of burning pruritus and urticarial-like lesions on the face and forearms. Patch testing was strongly positive for epoxy resin. The exposure was occupational to the re-formulation of microscopy immersion oil.
Evaluating performance of neural codes in neural communication networks (2017)

Information needs to be appropriately encoded to be reliably transmitted over a physical media. Similarly, neurons have their own codes to convey information in the brain. Even though it is well-know that neurons exchange information using a pool of several protocols of spatial-temporal encodings, the suitability of each code and their performance as a function of the network parameters and external stimuli is still one of the great mysteries in Neuroscience. This paper sheds light into this problem considering small networks of chemically and electrically coupled Hindmarsh-Rose spiking neurons. We focus on the mathematical fundamental aspects of a class of temporal and firing-rate codes that result from the neurons' action-potentials and phases, and quantify their performance by measuring the Mutual Information Rate, aka the rate of information exchange. A particularly interesting result regards the performance of the codes with respect to the way neurons are connected. We show that pairs of neurons that have the largest rate of information exchange using the interspike interval and firing-rate codes are not adjacent in the network, whereas the spiking-time and phase codes promote large exchange of information rate from adjacent neurons. This result, if possible to extend to larger neural networks, would suggest that small microcircuits of fully connected neurons, also known as cliques, would preferably exchange information using temporal codes (spiking-time and phase codes), whereas on the macroscopic scale, where typically there will be pairs of neurons that are not directly connected due to the brain's sparsity, the most efficient codes would be the firing rate and interspike interval codes, with the latter being closely related to the firing rate code.