gebhart/patrepeval huggingface dataset:
Rapid 3D printing of complex polymeric tubular catalytic micromotors (2016)

In this work two different lithography-based techniques are evaluated for high-throughput and complex 3D polymeric micromotors fabrication: high-power LED writing and two-photon absorption 3D laser lithography. Simple and double bubble-propelled catalytic micromotors are produced to assess the best geometrical features, demonstrating the versatility of the methods hereby presented to obtain complex structures of great interest for advanced microrobotics. Different parameters associated with their structure, as its inner surface roughness, conical aperture, and length, are studied. These parameters are of key importance for the final effective motion, as they determine the O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> bubble nucleation and motion behavior along the micromotors trajectory.
Approximate Boolean Operations on Large Polyhedral Solids with Partial Mesh Reconstruction (2010)

We present a new approach to compute the approximate Boolean operations of two freeform polygonal mesh solids efficiently with the help of Layered Depth Images (LDIs). After applying the LDI sampling-based membership classification, the most challenging part, a trimmed adaptive contouring algorithm, is developed to reconstruct the mesh surface from the LDI samples near the intersected regions and stitch it to the boundary of the retained surfaces. Our method of approximate Boolean operations holds the advantage of numerical robustness as the approach uses volumetric representation. However, unlike other methods based on volumetric representation, we do not damage the facets in nonintersected regions, thus preserving geometric details much better and speeding up the computation as well. We show that the proposed method can successfully compute the Boolean operations of free-form solids with a massive number of polygons in a few seconds.
Modeling and Control of High-Velocity Oxygen-Fuel (HVOF) Thermal Spray: A Tutorial Review (2009)

This work provides a tutorial overview of recent research efforts in modeling and control of the high-velocity oxygen-fuel (HVOF) thermal spray process. Initially, the modeling of the HVOF thermal spray, including combustion, gas dynamics, particle in-flight behavior, and coating microstructure evolution is reviewed. The influence of the process operating conditions as predicted by the fundamental models on particle characteristics and coating microstructure is then discussed and compared with experimental observations. Finally, the issues of measurement and automatic control are discussed and comments on potential future research efforts are made.
T-bet:Eomes Balance, Effector Function, and Proliferation of Cytomegalovirus-Specific CD8+ T Cells during Primary Infection Differentiates the Capacity for Durable Immune Control (2014)

CMV remains an important opportunistic pathogen in solid organ transplantation, particularly in lung transplant recipients (LTRs). LTRs mismatched for CMV (donor+/recipient-; D+R-) are at high-risk for active CMV infection and increased mortality, however the immune correlates of viral control remain incompletely understood. We prospectively studied 23 D+R- LTRs during primary CMV infection to determine whether acute CD8(+) T cell parameters differentiated the capacity for viral control in early chronic infection. T-box transcription factors expression patterns of T-bet > Eomesodermin (Eomes) differentiated LTR controllers from viremic relapsers and reciprocally correlated with granzyme B loading, and CMV phosphoprotein 65 (pp65)-specific CD8(+)IFN-γ(+) and CD107a(+) frequencies. LTR relapsers demonstrated reduced CD8(+)Ki67(+) cells ex vivo and substantially impaired CD8(+)pp65-specific in vitro proliferative responses at 6 d, with concomitantly lower pp65-specific CD4(+)IL-2(+) frequencies, as compared with LTR controllers. However, CMV-specific in vitro proliferative responses could be significantly rescued, most effectively with pp65 Ag and exogenous IL-2, resulting in an increased T-bet:Eomes balance, and enhanced effector function. Using class I CMV tetramers, we observed similar frequencies between relapsers and controllers, although reduced T-bet:Eomes balance in tetramer(+) cells from relapsers, along with impaired CD8(+) effector responses to tetramer-peptide restimulation. Taken together, these data show impaired CMV-specific CD8(+) effector responses is not for complete lack of CMV-specific cells but rather underscores the importance of the T-bet:Eomes balance, with CMV-specific proliferation a key factor driving early T-bet expression and effector function in CD8(+) T cells during primary infection and differentiating the capacity of high-risk LTRs to establish immune control during early chronic infection.
Lettre sur les sourds et muets. (1967)

place de choix parmi divers autres ouvrages critiques qui font honneur aux lumieres de nos dix-huitiemistes et qu'Otis Fellows enumere avec un evident plaisir dans sa preface. A bien des egards, le travail de Meyer peut etre considere comme exemplaire : « II a fallu attendre un erudit de la competence, de la patience et de la sagacite de Paul Meyer pour nous donner une edition digne de cet ouvrage », ecrit Georges May dans son Introduction enthousiaste. Ces autorites sont les bienvenues pour Fauteur du present article, qui n'est pas un specialiste et qui trouve une excuse a parler de leurs travaux dans Fadmiration qu'il porte a Diderot x et aux philosophes du 18e siecle. Les connaissances de M. Meyer sont profondes et etendues. Mon expose s'attachera d'abord a donner une idee des richesses que Fauteur nous apporte.
Mössbauer spectra of some organotin compounds of type R<sub>3</sub>SnX (1971)

The Mössbauer spectra of various organotin compounds of formula R3SnX have been recorded. Of particular interest are series of compounds containing tin–metal bonds: (π-C5H5)(CO)3M1–SnMe3(M1= Cr, Mo, W), Me3M2–SnMe3(M2= C, Si, Ge, Sn), Ph3M3–SnPh3(M3= Si, Ge, Sn), Ph3M4–SnMe3(M4= C, Si, Ge, Sn), (Ph3P)2(CO)H(X)Ir–SnPh3(X = Cl, I), (Ph3P)2(CO)Y(Cl)Ir–SnMe3(Y = H, D), (Ph2RP)2(CO)H(Cl)Ir–SnPh3(R = Me, Ph). The results are discussed.
Schizosaccharomyces pombe homologue of glutathione peroxidase, which does not contain selenocysteine, is induced by several stresses and works as an antioxidant (1999)

We have cloned a gene of Schizosaccharomyces pombe homologues to the glutathione peroxidase gene. The cloned gene, named gpx1(+), encoded a protein that was 158 amino acids in length and had a molecular mass of 18 kDa. The gpx1(+) gene is homologous with many glutathione peroxidase genes but the selenocysteine codon (UGA) position of mammalian genes is a cysteine codon (UGU) in S. pombe. gpx1(+) mRNA was induced by various stresses, including oxidative stress, osmostress and heat stress. These stresses activate the Wis1-Sty1/Spc1 MAP kinase cascade in S. pombe. Transcriptional factors Atf1 and Pap1 are under the control of this MAP kinase. In the disruption of the atf1(+) gene, gpx1(+) was not transcribed or induced. However, the expression of gpx1(+) was not affected by the disruption of the pap1(+) gene. These results indicated that gpx1(+) was under the control of transcription factor Atf1. Catalase can detoxicate H(2)O(2) in the same way as GPx and the disruptant of the catalase gene of S. pombe is hypersensitive to H(2)O(2). The catalase gene disruptant of S. pombe harbouring multicopy plasmid containing gpx1(+) restored the hypersensitivity to H(2)O(2) of the catalase gene disruptant. These results suggest that Gpx1 acts as a scavenger of H(2)O(2) in vivo.
Protein Kinase Cα Phosphorylates and Negatively Regulates Diacylglycerol Kinase ζ (2003)

Diacylglycerol kinase (DGK) terminates diacylglycerol (DAG) signaling by phosphorylating DAG to produce phosphatidic acid, which also has signaling properties. Thus, precise control of DGK activity is essential for proper signal transduction. We demonstrated previously that a peptide corresponding to the myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation site domain (PSD) in DGK zeta was phosphorylated in vitro by an active fragment of protein kinase C (PKC). In the present study, we tested full-length DGK zeta and found that PKC alpha phosphorylated DGK zeta on serines within the MARCKS PSD in vitro and in vivo. DGK zeta also coimmunoprecipitated with PKC alpha, suggesting that they reside in a regulated signaling complex. We then tested whether phosphorylation affected DAG kinase activity. We found that a mutant (DGK zeta S/D) in which serines within the MARCKS PSD were altered to aspartates (to mimic phosphorylation) had lower activity compared with wild-type DGK zeta or a control mutant (DGK zeta S/N) in which the same serines were changed to asparagines. Furthermore, activation of PKC alpha by phorbol 12-myristate 13-acetate inhibited the activity of wild-type DGK zeta, but not DGK zeta S/D, in human embryonic kidney 293 cells. These results suggest that by phosphorylating the MARCKS PSD, PKC alpha attenuates DGK zeta activity. Supporting this, we found that cells expressing DGK zeta S/D had higher DAG levels and grew more rapidly compared with cells expressing DGK zeta S/N that could not be phosphorylated. Taken together, these results indicate that PKC alpha phosphorylates DGK zeta in cells, and this phosphorylation inhibits its kinase activity to remove cellular DAG, thereby affecting cell growth.
Holographic Twyman-Green Interferometer (1984)

Off-axis Fresnel zone plate used to obtain fringe visibility close to unity. Holographic Twyman-Green Interferometer (HTG) employs off-axis Fresnel zone plate (OFZP) as beam splitter and beam diverger in place of two separate elements that perform those functions in conventional TwymanGreen interferometer.
EMI/EMC in printed circuit boards-a literature review (1992)

The problem areas and literature related to the EMI/EMC of printed circuit boards are reviewed. The goal of the authors is to give an overview of present research and aid those seeking more detailed references on specific topics including: emissions, susceptibility, crosstalk, traces, connections, grounding, and components.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Emergency Physician Treatment of Acute Stroke with Recombinant Tissue Plasminogen Activator: A Retrospective Analysis (1999)

In this analysis, EPs, with specialty consultation as required, successfully identified patients with AIS and delivered rt-PA with satisfactory outcomes. Important elements of this model include early patient identification, preestablished protocols, and rapid access to CT scanning and interpretation.
Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers. (1989)

With a standard set of primers directed toward conserved regions, we have used the polymerase chain reaction to amplify homologous segments of mtDNA from more than 100 animal species, including mammals, birds, amphibians, fishes, and some invertebrates. Amplification and direct sequencing were possible using unpurified mtDNA from nanogram samples of fresh specimens and microgram amounts of tissues preserved for months in alcohol or decades in the dry state. The bird and fish sequences evolve with the same strong bias toward transitions that holds for mammals. However, because the light strand of birds is deficient in thymine, thymine to cytosine transitions are less common than in other taxa. Amino acid replacement in a segment of the cytochrome b gene is faster in mammals and birds than in fishes and the pattern of replacements fits the structural hypothesis for cytochrome b. The unexpectedly wide taxonomic utility of these primers offers opportunities for phylogenetic and population research.
Highly Enantioselective Organocatalytic Carbonyl‐Ene Reaction with Strongly Acidic, Chiral Brønsted Acids as Efficient Catalysts (2008)

You can count on the counterion in ion-pair intermediates to induce high levels of asymmetry in the title reaction. The efficient transformation proceeds under mild reaction conditions in the presence of an air-stable N-triflylphosphoramide in a low catalyst loading of just 1 mol % to give substituted α-hydroxyesters in good yields and with excellent ee values (see scheme; R=aryl).
Parallel Metropolis coupled Markov chain Monte Carlo for Bayesian phylogenetic inference (2004)

This paper presents a parallel algorithm for (MC)(3). The proposed parallel algorithm retains the ability to explore multiple peaks in the posterior distribution of trees while maintaining a fast execution time. The algorithm has been implemented using two popular parallel programming models: message passing and shared memory. Performance results indicate nearly linear speed improvement in both programming models for small and large data sets.
Nonaqueous electrochromatography on continuous bed columns of sol–gel bonded large‐pore C30 material: Separation of retinyl esters (2000)

A nonaqueous electrochromatographic reversed-phase separation method for retinyl esters using continuous bed columns has been developed. The packing material was C30 modified material large-pore silica (5 μm Nucleosil 4000 Å). The continuous bed columns were prepared by sol–gel bonding in 180 μm inside diameter fused silica capillaries. The mobile phase consisting of 2.5 mM lithium acetate in N,N-dimethylformamide-acetonitrile-methanol (2+7+1, v/v) gave rise to an electroosmotic flow of 1 mm/s at 350 V/cm and 40°C. Using a 36 cm effective length column separation of the commercially available and synthesized standards (all-trans-retinyl acetate, palmitate, heptadecanoate, stearate, oleoate, and linoleoate) was obtained within 12 min. Separation of isomeric retinyl palmitate (13-cis- and all-trans-retinyl palmitate) was also obtained. The selectivity was found to be temperature dependent in the temperature range investigated (30–60°C). The within-day and between-day variations (n=3) of retention times of all-trans-retinyl palmitate were 0.2% relative standard deviation (RSD) and <2.5% RSD, respectively. Further, the within-day and between-day variations (n=3) of peak areas were in both cases <4% RSD using injection. The column examined was stable for more than 1 month of extensive use. Liver extracts from arctic seal were analyzed. © 2001 John Wiley & Sons, Inc. J Micro Sep 12: 561–567, 2000
Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases Aβ1–42 Clearance (2014)

Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) is a resident endoplasmic reticulum enzyme that prevents the buildup of cholesterol in membranes by converting it to cholesterol esters. Blocking ACAT1 pharmacologically or by Acat1 gene knock-out (KO) decreases amyloidopathy in mouse models for Alzheimer's disease. However, the beneficial actions of ACAT1 blockage to treat Alzheimer's disease remained not well understood. Microglia play essential roles in the proteolytic clearance of amyloid β (Aβ) peptides. Here we show that Acat1 gene KO in mouse increases phagocytic uptake of oligomeric Aβ1-42 and stimulates lysosomal Aβ1-42 degradation in cultured microglia and in vivo. Additional results show that Acat1 gene KO or a specific ACAT1 inhibitor K604 stimulates autophagosome formation and transcription factor EB-mediated lysosomal proteolysis. Surprisingly, the effect of ACAT1 blockage does not alter mTOR signaling or endoplasmic reticulum stress response but can be modulated by agents that disrupt cholesterol biosynthesis. To our knowledge, our current study provides the first example that a small molecule (K604) can promote autophagy in an mTOR-independent manner to activate the coordinated lysosomal expression and regulation network. Autophagy is needed to degrade misfolded proteins/peptides. Our results implicate that blocking ACAT1 may provide a new way to benefit multiple neurodegenerative diseases.
Dynamics of nonthermal reactions: femtosecond surface chemistry (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamics of nonthermal reactions: femtosecond surface chemistryR. R. Cavanagh, D. S. King, J. C. Stephenson, and T. F. HeinzCite this: J. Phys. Chem. 1993, 97, 4, 786–798Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/j100106a002https://doi.org/10.1021/j100106a002research-articleACS PublicationsRequest reuse permissionsArticle Views513Altmetric-Citations178LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Autonomous Soaring: The Montague Cross-Country Challenge (2010)

A novel method was developed for locating and allowing gliders to stay in thermals (convective updrafts). The method was applied to a 5 kg, glider, called ALOFT (autonomous locator of thermals), that was entered in the 2008 Montague Cross-Country Challenge held on 13-15 June 2008 in Montague, California. In this competition, remote-controlled gliders in the 5 kg class competed on the basis of speed and distance. ALOFT was the first known autonomously soaring aircraft to enter a soaring competition and its entry provided a valuable comparison between the effectiveness of manual soaring and autonomous soaring. ALOFT placed third in the competition in overall points, outperforming manually-flown aircraft in its ability to center and use updrafts, especially at higher altitudes and in the presence of wind, to fly more optimal airspeeds, and to fly directly between turn points. The results confirm that autonomous soaring is a bona fide engineering subdiscipline, which is expected to be of interest to engineers, who might find that this has some utility in the aviation industry.
Amyloid Beta: Multiple Mechanisms of Toxicity and Only Some Protective Effects? (2014)

Amyloid beta (Aβ) is a peptide of 39-43 amino acids found in large amounts and forming deposits in the brain tissue of patients with Alzheimer's disease (AD). For this reason, it has been implicated in the pathophysiology of damage observed in this type of dementia. However, the role of Aβ in the pathophysiology of AD is not yet precisely understood. Aβ has been experimentally shown to have a wide range of toxic mechanisms in vivo and in vitro, such as excitotoxicity, mitochondrial alterations, synaptic dysfunction, altered calcium homeostasis, oxidative stress, and so forth. In contrast, Aβ has also shown some interesting neuroprotective and physiological properties under certain experimental conditions, suggesting that both physiological and pathological roles of Aβ may depend on several factors. In this paper, we reviewed both toxic and protective mechanisms of Aβ to further explore what their potential roles could be in the pathophysiology of AD. The complete understanding of such apparently opposed effects will also be an important guide for the therapeutic efforts coming in the future.
Sociodemographic and meteorological correlates of sudden infant death in <scp>T</scp>aiwan (2012)

Sociodemographic, geographic and meteorological data can be used to identify families in greater need of early guidance and to promote various prevention measures to avoid the occurrence of SIDS.
Introduction: Prelude to Definitive Elaborations (2007)

Anti-essentialist social constructionist identity politics is becoming institutionalized in literary studies. The same could be said of other areas of academic study, across the humanities and the social sciences. Indeed the same could be said of a wide range of political, social, and cultural formations in our time. That the second part of this book is addressed primarily to the institutional practice of literary studies is a convenience, or rather is to demarcate an examinable ground on which such institutionalization can be demonstrated. I am convinced that it can also be demonstrated for other grounds; the case of literary studies in this regard is symptomatic of a larger phenomenon.
Identification of a 3'-->5' exonuclease activity associated with human RNA polymerase II. (1993)

Human RNA polymerase II is shown to be associated with a 3'-->5' exonuclease activity that removes nucleoside 5'-monophosphates from the 3' end of the transcripts in isolated ternary complexes. This activity is stimulated by SII, a protein that acts as a transcription elongation factor in vitro. In addition, we show that another transcription factor, TFIIF, stimulates a competing pyrophosphorolysis reaction. These findings raise interesting questions about the roles of these activities in vivo, including the possibility that this RNA polymerase may proofread the nascent transcript.
Optimization of Localized Surface Plasmon Resonance Transducers for Studying Carbohydrate–Protein Interactions (2011)

Noble metal nanostructures supporting localized surface plasmons (SPs) have been widely applied to chemical and biological sensing. Changes in the refractive index near the nanostructures affect the SP extinction band, making localized surface plasmon resonance (LSPR) spectroscopy a convenient tool for studying biological interactions. Carbohydrate-protein interactions are of major importance in living organisms; their study is crucial for understanding of basic biological processes and for the construction of biosensors for diagnostics and drug development. Here LSPR transducers based on gold island films prepared by evaporation on glass and annealing were optimized for monitoring the specific interaction between Concanavalin A (Con A) and D-(+)-mannose. The sugar was modified with a PEG-thiol linker and immobilized on the Au islands. Sensing assays were performed under stationary and flow conditions, the latter providing kinetic parameters for protein binding and dissociation. Ellipsometry and Fourier transform-infrared (FT-IR) data, as well as scanning electron microscopy (SEM) imaging of fixated and stained samples, furnished independent evidence for the protein-sugar recognition. Enhanced response and visual detection of protein binding was demonstrated using Au nanoparticles stabilized with the linker-modified mannose molecules. Mannose-coated transducers display an excellent selectivity toward Con A in the presence of a large excess of bovine serum albumin (BSA).