gebhart/patrepeval huggingface dataset:
Quantitative T<sub>2</sub> mapping of the mouse heart by segmented MLEV phase‐cycled T<sub>2</sub> preparation (2013)

T2 prepared imaging provides high quality reproducible T2 maps of healthy and diseased mouse myocardium.
A risk forecasting process for nanostructured materials, and nanomanufacturing (2011)

International audience
Foveation in near-eye holographic display (2018)

Foveation is applied for the near-eye holographic display to relieve the requirement of the computing power and the space-bandwidth-product. Foveated point cloud data reduces the computational load in hologram synthesis and the foveated holographic display provides field of view exceeding the given space-bandwidth-product.
Quantification of <i>Magnaporthe grisea</i> During Infection of Rice Plants Using Real-Time Polymerase Chain Reaction and Northern Blot/Phosphoimaging Analyses (2002)

Rice blast, caused by Magnaporthe grisea, is a serious fungal disease of rice worldwide. Currently, evaluation of the fungal pathogenicity and host resistance is mainly based on a disease rating or measurement of blast lesion number and size. However, these methods only provide visual estimation rather than accurate measurement of fungal growth in rice plants. In this study, DNA-based real-time polymerase chain reaction (PCR) and RNA-based northern blot/phosphoimaging analyses were evaluated to quantify M. grisea. Both methods were sensitive, specific, and reproducible and could accurately measure the relative growth and absolute biomass of M. grisea. The real-time PCR analysis showed that the growth of M. grisea in seedling leaves of susceptible cultivars (M201 and Wells) was ≈46 to 80 times higher than that of a resistant cultivar (Drew) at 4 and 6 days after inoculation. The data obtained from the real-time PCR assays also were consistent with that from northern blot/ phosphoimaging analysis. However, the real-time PCR approach was much faster and more convenient in most cases. Therefore, it is an excellent tool for in planta quantification of M. grisea and can be used for reliable assessment of fungal pathogenicity and host resistance
Magnetic ferrites: New materials for modern applications (1954)

Ferrites are serving very effectively in the vanguard of communication developments. Their basic properties and methods of application are discussed which show how they have begun to revolutionize the design and manufacture of inductors and transformers.
Vacuum sublimation behavior of various metal chelates of 4-anilino-3-pentene-2-one, acetylacetone, dithiocarbamates, oxine and its derivatives, dimethylglyoxime, dithizone, 1-(2-pyridylazo)-2-naphthol, and tetraphenylporphyrin (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVacuum sublimation behavior of various metal chelates of 4-anilino-3-pentene-2-one, acetylacetone, dithiocarbamates, oxine and its derivatives, dimethylglyoxime, dithizone, 1-(2-pyridylazo)-2-naphthol, and tetraphenylporphyrinTakaharu. Honjo, Hisanori. Imura, Shigeki. Shima, and Toshiyasu. KibaCite this: Anal. Chem. 1978, 50, 11, 1545–1552Publication Date (Print):September 1, 1978Publication History Published online1 May 2002Published inissue 1 September 1978https://pubs.acs.org/doi/10.1021/ac50033a039https://doi.org/10.1021/ac50033a039research-articleACS PublicationsRequest reuse permissionsArticle Views231Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Trigger-based approach with hidden node problem for uplink multi-user transmission in 802.11ax (2017)

To enable uplink (UL) multi-user (MU) transmission in 802.11ax, the Access Point (AP) sends a Trigger Frame to schedule stations (STAs) to send their UL data, and uses the new MU Request to Send (RTS) mechanism to protect large MU transmissions from hidden nodes. This paper addresses the potential problem of having one or more solicited STAs with nonzero Network Allocation Vector (NAV). This would reduce the system efficiency as some allocated resources will not be exploited for the reserved uplink transmission period. Accordingly, this paper proposes a variant of the Trigger operation considering the employment of massive multiple input and multiple output (MIMO) on the AP side, designated as Massive MU RTS (MMU-RTS) mechanism. In the proposed mechanism, some backup STAs not included on the trigger list, but having zero NAV are permitted to respond to the AP together with the solicited STAs. In particular, two user selection algorithms are proposed for the MMU-RTS mechanism. The efficiency of the proposed method is demonstrated through extensive numerical simulations.
CO<sub>2</sub> Stimulation of the Cornea: A Comparison Between Human Sensation and Nerve Activity in Polymodal Nociceptive Afferents of the Cat (1995)

Excitation of nociceptors by low pH has been proposed as a cause of pain following tissue injury. Here we have studied the effect of pH reductions caused by application of CO2 pulses to the cornea on the activity of corneal afferent nerves of the cat and on the magnitude of pain sensations in humans. Single-unit activity was recorded from corneal afferent fibres in anaesthetized cats. The corneal receptive field of A-delta or C polymodal nociceptive units was exposed for 30 s to a gas mixture with different concentrations of CO2 in air (0, 35, 50, 65, 80 and 98.5%). Responses to CO2 were evoked at a mean threshold concentration of 40 +/- 3% CO2. They consisted of a discharge of impulses that decayed gradually to a tonic level. In 15% of the units the initial burst was absent. The CO2 concentration and firing frequency data could be fitted to a power function with an exponent of 1.12. Pulses of CO2 were also applied to the cornea of 16 human volunteers. Sensations experienced were measured by means of a visual analogue scale and a verbal descriptor scale. Flow was adjusted below the mechanical stimulation threshold (2.8 +/- 0.5 mg). When mixtures containing 10-90% CO2 in 5% steps were applied as 3 s pulses, threshold sensation, described as a mild stinging pain, was evoked at 33.5 +/- 4.0% CO2. This sensation became overtly painful with higher CO2 concentrations (47.5 +/- 3.6% CO2). For the same subject the sensory threshold was remarkably constant, though it changed with longer exposure times. The relationship between CO2 concentration and magnitude of pain could be adjusted to a power function with a power exponent of 1.12. Curves of CO2 concentration versus neural discharges in the cat and versus psychophysical sensation in humans were very similar. These results show that corneal polymodal nociceptors respond to protons, and encode changes in CO2 concentration presumably reflecting pH changes. The same stimulus evokes corneal pain sensations in humans, thus opening the possibility of using CO2 as an effective stimulus for corneal aesthesiometry.
Cellular Mechanisms and Prospective Applications of Hypericin in Photodynamic Therapy (2006)

During the last decades, Photodynamic Therapy (PDT) has been established as a powerful alternative approved by health agencies of several countries for treatment of various malignant and some non-malignant diseases. PDT makes use of the light-induced destruction of target cells by formation of cytotoxic products in the presence of a photosensitizing agent and oxygen. The light-dependent tumor destructive properties of Hypericin have drawn attention to its promising application as a photosensitizer in the frame of PDT. Hypericin is a naturally occurring secondary metabolite in plants of the Hypericum genus, with Hypericum perforatum (St. John's wort) as it is a commonly known representative. This review focuses on the cellular mechanisms of Hypericin-based phototoxicity and provides an outlook for future application of Hypericin as a fluorescing and photosensitizing agent for diagnosis and treatment of cancerous diseases, respectively.
Tyrosine Dephosphorylation of Nuclear Proteins Mimics Transforming Growth Factor β1 Stimulation of α2(I) Collagen Gene Expression (1995)

Transforming growth factor beta 1 (TGF-beta 1) exerts a positive effect on the transcription of genes coding for several extracellular matrix-related products, including collagen I. We have previously identified a strong TGF-beta 1-responsive element (TbRE) in the upstream promoter sequence of the alpha 2(I) collagen (COL1A2) gene. Our experiments have shown that TGF-beta 1 stimulates COL1A2 transcription by increasing binding of an Sp1-containing complex (TbRC) to the TbRE. They have also suggested that the change occurs via posttranslational modification of a protein(s) directly or indirectly interacting with Sp1. Here, we provide evidence showing that tyrosine dephosphorylation of nuclear proteins mimics the stimulation of COL1A2 transcription by the TGF-beta 1-activated signaling pathway. Preincubation of nuclear extracts with protein tyrosine phosphatase (PTPase) but not with protein phosphatase type 2A (PP2A), a serine/threonine phosphatase, enhanced binding of the TbRC to the same degree as culturing cells in TGF-beta 1. Consistent with these in vitro findings, genistein, a tyrosine kinase inhibitor, led to markedly increased COL1A2 gene expression, whereas sodium orthovanadate, a tyrosine phosphatase inhibitor, decreased it substantially. These results were supported by transfection experiments showing that genistein and sodium orthovanadate have opposite effects on TbRE-mediated transcription. Moreover, nuclear proteins isolated from genistein-treated cells were found to interact with the TbRE significantly more than those from untreated cells. Furthermore, pretreatment of cells with sodium orthovanadate virtually abrogated nuclear protein binding to the TbRE, but not to a neighboring cis-acting element unresponsive to TGF-beta 1. The results of this study, therefore, provide the first correlation between tyrosine dephosphorylation, increased binding of a transcriptional complex, and TGF-beta 1 stimulation of gene expression.
THE HEAT CAPACITIES AT LOW TEMPERATURES OF MANGANESE SULFIDE, FERROUS SULFIDE AND CALCIUM SULFIDE (1931)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE HEAT CAPACITIES AT LOW TEMPERATURES OF MANGANESE SULFIDE, FERROUS SULFIDE AND CALCIUM SULFIDEC. Travis. AndersonCite this: J. Am. Chem. Soc. 1931, 53, 2, 476–483Publication Date (Print):February 1, 1931Publication History Published online1 May 2002Published inissue 1 February 1931https://pubs.acs.org/doi/10.1021/ja01353a010https://doi.org/10.1021/ja01353a010research-articleACS PublicationsRequest reuse permissionsArticle Views182Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
MicroRNA-29c mediates initiation of gastric carcinogenesis by directly targeting ITGB1 (2014)

MiR-29c acts as a tumour suppressor in GC by directly targeting ITGB1. Loss of miR-29c expression is an early event in the initiation of gastric carcinogenesis and may serve as a diagnostic and therapeutic biomarker for patients with GC.
Windows NTサーバー4.0アドミニストレータガイド (1997)

第１部 セキュリティ（セキュリティを定義する；セキュリティ：ファイアウォールと関連する問題；コンピュータウィルスとＷｉｎｄｏｗｓ ＮＴ ほか） 第２部 トラブルシューティング（ブートプロセス；セキュリティとトラブルシューティング；レジストリ ほか） 第３部 最適化（パフォーマンスの最適化；容量プランニング；パフォーマンスモニタの使い方；Ｗｉｎｄｏｗｓ ＮＴサーバークライアントのサポート）
Cancer Stem Cells: A Review of Potential Clinical Applications (2012)

Despite a lack of consensus in the scientific community on research methodology, CSCs have demonstrated significant potential as therapeutic targets in the treatment of cancer. Further research of CSC biology and markers will eventually lead to the development of novel therapeutic approaches for targeting these cells to treat resistant and recurrent tumors and minimal residual disease.
Liposomal drug delivery, a novel approach: PLARosomes. (2000)

Almost from the time of their rediscovery in the 60's and the demonstration of their entrapment potential, liposomal vesicles have drawn attention of researchers as potential carriers of various bioactive molecules that could be used for therapeutic applications in humans and animals. Several commercial liposome-based drugs have already been discovered, registered and introduced with great success on the pharmaceutical market. However, further studies, focusing on the elaboration of more efficient and stable amphiphile-based vesicular (or non-viral) drug carriers are still under investigation. In this review we present the achievements of our group in this field. We have discovered that natural amphiphilic dihydroxyphenols and their semisynthetic derivatives are promising additives to liposomal lipid compositions. The presence of these compounds in lipid composition enhances liposomal drug encapsulation, reduces the amount of the lipid carrier necessary for efficient entrapment of anthracycline drugs by a factor of two, stabilizes liposomal formulation of the drug (both in suspension and in a lyophilized powder), does not influence liposomal fate in the blood circulation system and benefits from other biological activities of their resorcinolic lipid modifiers.
Safety of Virus-Resistant Transgenic Plants Two Decades After Their Introduction: Lessons from Realistic Field Risk Assessment Studies (2007)

Potential safety issues have been raised with the development and release of virus-resistant transgenic plants. This review focuses on safety assessment with a special emphasis on crops that have been commercialized or extensively tested in the field such as squash, papaya, plum, grape, and sugar beet. We discuss topics commonly perceived to be of concern to the environment and to human health--heteroencapsidation, recombination, synergism, gene flow, impact on nontarget organisms, and food safety in terms of allergenicity. The wealth of field observations and experimental data is critically evaluated to draw inferences on the most relevant issues. We also express inside views on the safety and benefits of virus-resistant transgenic plants, and recommend realistic risk assessment approaches to assist their timely deregulation and release.
Androgens Differentially Potentiate Mouse Intestinal Smooth Muscle by Nongenomic Activation of Polyamine Synthesis and Rho Kinase Activation (2006)

We demonstrate that testosterone and its active metabolite 5alpha-dihydrotestosterone acutely (approximately 30 min) potentiate mouse ileal, but not duodenal, muscle activity. Androgens augment the amplitude of spontaneous peak-to-peak oscillations, alter the spontaneous activity frequency spectrum, and increase the amplitude of calcium-induced and carbachol-induced contractions. Concentration-dependence analyses revealed that maximal potentiation (449-910%) occurred at physiological concentrations of androgens (100 pM to 10 nM) with EC50 values in the picomolar range (8-20 pM). Western blot analyses using an antiandrogen receptor (anti-AR) antibody revealed the presence of two different AR proteins migrating at 87 and 110 kDa in ileal, but not duodenal, extracts. Androgen-induced potentiation was prevented by preincubation with AR antagonists flutamide or cyproterone acetate but was unaffected by pretreatment with cycloheximide plus actinomycin D, indicating that potentiation was mediated by ARs via a novel nongenomic mechanism. Androgen effects were mimicked by polyamines putrescine and spermine and were blocked by the ornithine decarboxylase and S-adenosyl-L-methionine decarboxylase inhibitors alpha-difluoromethylornithine and berenil, respectively. Accordingly, androgens increase alpha-difluoromethylornithine-sensitive ornithine-decarboxylase- mediated L-ornithine decarboxylation in ileal tissues within the same time course as isometric potentiation. Both putrescine and dihydrotestosterone induced Ca2+ sensitization of ionomycin-permeabilized ileal smooth muscle. Finally, inhibition of the Rho kinase (ROK) pathway with the specific inhibitor Y27632 completely prevented androgen-induced potentiation. In agreement, androgens elicited ROK-induced Ser19 phosphorylation of myosin light chain 2 in ileal muscle. These data indicate that androgens potentiate ileal contractile activity by an AR-dependent nongenomic mechanism involving intracellular polyamine signaling and Ca2+ sensitization via ROK activation.
The tripole antenna: An adaptive array with full polarization flexibility (1980)

The performance of an adaptive array using three mutually perpendicular dipoles (a tripole) was studied. A desired signal and an interference signal, each with arbitrary angle of arrival and polarization, are assumed incident on the array. Uncorrelated thermal noise is also assumed present on each element signal. The output desired signal-to-interference-plus-noise ratio (SNIR) is computed as a function of the signal arrival angles and polarizations. It is shown that, for most angles of arrival and polarizations, the array has an excellent ability to protect a desired signal from interference. Certain special cases where the performance is not good are discussed in detail. (Author)
Synthesis and estrogen receptor binding of novel 11.beta.-substituted estra-1,3,5(10)-triene-3,17.beta.-diols (1990)

As part of our program to develop estrogenic radioligands for use in nuclear medicine, a study was undertaken to investigate the effect of substituents on the receptor affinity of putative radiochemicals. In the study a synthetic strategy directed toward the introduction of an 11 beta-(fluoroethyl) substituent was devised. The target compound 9 was prepared via a five-step procedure starting from 11 beta-vinylestrone 3-acetate (4) in an overall 43% yield. The stereochemistry of the 11 beta-vinyl moiety was established by X-ray crystallography. The final product and several analogues, 11 beta-ethyl-, -vinyl-, and (hydroxyethyl)estradiols (11, 5, and 12), were evaluated for their estrogen receptor binding affinity. The results indicate that the target compound and several 11 beta-substituted analogues possess relative binding affinities greater than of estradiol and its 16 alpha-fluorinated derivatives. The manner in which the target compound 9 was prepared is amenable to use with 18F incorporation.
Putative Origins of Cell-Free DNA in Humans: A Review of Active and Passive Nucleic Acid Release Mechanisms (2020)

Through various pathways of cell death, degradation, and regulated extrusion, partial or complete genomes of various origins (e.g., host cells, fetal cells, and infiltrating viruses and microbes) are continuously shed into human body fluids in the form of segmented cell-free DNA (cfDNA) molecules. While the genetic complexity of total cfDNA is vast, the development of progressively efficient extraction, high-throughput sequencing, characterization via bioinformatics procedures, and detection have resulted in increasingly accurate partitioning and profiling of cfDNA subtypes. Not surprisingly, cfDNA analysis is emerging as a powerful clinical tool in many branches of medicine. In addition, the low invasiveness of longitudinal cfDNA sampling provides unprecedented access to study temporal genomic changes in a variety of contexts. However, the genetic diversity of cfDNA is also a great source of ambiguity and poses significant experimental and analytical challenges. For example, the cfDNA population in the bloodstream is heterogeneous and also fluctuates dynamically, differs between individuals, and exhibits numerous overlapping features despite often originating from different sources and processes. Therefore, a deeper understanding of the determining variables that impact the properties of cfDNA is crucial, however, thus far, is largely lacking. In this work we review recent and historical research on active vs. passive release mechanisms and estimate the significance and extent of their contribution to the composition of cfDNA.
Description of a new Sonoran snake of the genus Ficimia, with notes on other Mexican species (1936)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
2.2‐Bis‐trifluormethyl‐oxazolidone‐(5) (1966)

Abstract Durch Umsetzung von 26 α‐Aminosäuren, α‐Iminosäuren und Derivaten trifunktioneller α‐Aminosäuren mit Hexafluoraceton, vorzugsweise in Dimethylsulfoxyd, wurden die entsprechend substituierten 2.2‐Bis‐trifluormethyl‐oxazolidone‐(5) z. T. in hervorragenden Ausbeuten gewonnen. Die Oxazolidone aus α‐Monoamino‐monocarbonsäuren sind schon bei 80 gaschromatographierbar. Peptidsynthesen mit den Oxazolidonen sind möglich.
Terahertz pulsed spectroscopic imaging using optimized binary masks (2009)

We report the development of a terahertz pulsed spectroscopic imaging system based on the concept of compressive sensing. A single-point terahertz detector, together with a set of 40 optimized two-dimensional binary masks, was used to measure the terahertz waveforms transmitted through a sample. Terahertz time- and frequency-domain images of the sample comprising 20×20 pixels were subsequently reconstructed. We demonstrate that both the spatial distribution and the spectral characteristics of a sample can be obtained by this means. Compared with conventional terahertz pulsed imaging, no raster scanning of the object is required, and ten times fewer terahertz spectra need be taken. It is therefore ideal for real-time imaging applications.