gebhart/patrepeval huggingface dataset:
Role of Scarf and Its Binding Target Proteins in Epidermal Calcium Homeostasis (2007)

The novel Ca2+-binding protein, Scarf (skin calmodulin-related factor) belongs to the calmodulin-like protein family and is expressed in the differentiated layers of the epidermis. To determine the roles of Scarf during stratification, we set out to identify the binding target proteins by affinity chromatography and subsequent analysis by mass spectrometry. Several binding factors, including 14-3-3s, annexins, calreticulin, ERp72 (endoplasmic reticulum protein 72), and nucleolin, were identified, and their interactions with Scarf were corroborated by co-immunoprecipitation and co-localization analyses. To further understand the functions of Scarf in epidermis in vivo, we altered the epidermal Ca2+ gradient by acute barrier disruption. The change in the expression levels of Scarf and its binding target proteins were determined by immunohistochemistry and Western blot analysis. The expression of Scarf, annexins, calreticulin, and ERp72 were up-regulated by Ca2+ gradient disruption, whereas the expression of 14-3-3s and nucleolin was reduced. Because annexins, calreticulin, and ERp72 have been implicated in Ca2+-induced cellular trafficking, including the secretion of lamellar bodies and Ca2+ homeostasis, we propose that the interaction of Scarf with these proteins might be crucial in the process of barrier restoration. On the other hand, down-regulation of 14-3-3s and nucleolin is potentially involved in the process of keratinocyte differentiation and growth inhibition. The calcium-dependent localization and up-regulation of Scarf and its binding target proteins were studied in mouse keratinocytes treated with ionomycin and during the wound-healing process. We found increased expression and nuclear presence of Scarf in the epidermis of the wound edge 4 and 7 days post-wounding, entailing the role of Scarf in barrier restoration. Our results suggest that Scarf plays a critical role as a Ca2+ sensor, potentially regulating the function of its binding target proteins in a Ca2+-dependent manner in the process of restoration of epidermal Ca2+ gradient as well as during epidermal barrier formation.
Isolation and characterization of the highly immunogenic cell wall-associated protein of <i>Mycobacterium leprae</i>. (1989)

In a recent study, we demonstrated that certain reactivities crucial to the immune response in leprosy are due to protein associated with the cell wall peptidoglycan "core" of Mycobacterium leprae. We now describe a primary method for the isolation of a highly immunogenic, large molecular-size, cell wall protein (CW-P) complex from M. leprae, freed of soluble proteins, bound mycolates, arabinogalactan, and much of the peptidoglycan. The complex is of apparent relative molecular size 2 x 10(6) to 20 x 10(6) Da, is distinguished by a high content of Ala, Gly, Leu, Asx, and Glx, and some peptidoglycan, and represents up to 7% of the bacterial mass. It is stable to a variety of dissociation and reductive processes and, in accord with its size, is not resolvable by polyacrylamide gel electrophoresis. The mAb to the CW-P complex also react with the heat shock 65-kDa protein of M. leprae. Conversely, antibodies that recognize internal epitopes within the polypeptide chain of the heat shock protein also react with CW-P; however, antibodies that recognize the N and C termini of the 65-kDa protein fail to react with CW-P, and some anti-CW-P mAb do not recognize any of the soluble proteins of M. leprae. Alternate methods to derive the large peptidoglycan-associated protein result in lower yield and less of the associated heat shock protein, implying that the 65-kDa protein may not be crucial to the immunogenicity of the complex. In an accompanying paper, we demonstrate that T cell clones raised to CW-P also selectively recognize soluble proteins, primarily of 7-kDa and 16-kDa size. Thus, the image of the CW-P complex of M. leprae is of a few immunoreactive polypeptides in avid association with a modicum of peptidoglycan to which the 65-kDa polypeptide may be variably attached, perhaps due to involvement in assembly of the complex.
Two-mirror beam-shaping technique for high-power diode bars (1996)

A simple beam-shaping technique is described whereby the output from a highly asymmetric non-diffractionlimited laser source, such as a high-power diode bar, can be reconfigured with nearly equal beam-quality factors in orthogonal planes and without a significant reduction in brightness. Using this technique, in conjunction with conventional lenses, we have focused the output from a 20-W cw diode bar to a very intense, nearly circular spot with a 1/e(2) beam diameter of ~100 microm and a far-field beam divergence (half-angle) of ~0.2 rad.
High-performance arithmetic coding VLSI macro for the H264 video compression standard (2005)

This paper investigates the algorithmic complexity of arithmetic coding in the new H264 video coding standard and proposes a processor-coprocessor architecture to reduce it by more than an order of magnitude. The proposed coprocessor is based on an innovative algorithm known as the MZ-coder and maintains the original coding efficiency via a low-complexity, multiplication-free, non-stalling, fully pipelined architecture. The coprocessor achieves a constant throughput for both coding and decoding processes of 1 symbol per cycle and is designed to be attached to a controlling embedded RISC CPU whose instruction set has been extended with arithmetic coding instructions.
Segment-based approach for subsequence searches in sequence databases (2001)

Article Share on Segment-based approach for subsequence searches in sequence databases Authors: Sanghyun Park Department of Computer Science, University of California, Los, Angeles, Los Angeles, CA Department of Computer Science, University of California, Los, Angeles, Los Angeles, CAView Profile , Sang-Wook Kim Department of Computer, Information, and Communications Engineering, Kangwon National University, Korea Department of Computer, Information, and Communications Engineering, Kangwon National University, KoreaView Profile , Wesley W. Chu Department of Computer Science, University of California, Los Angeles, Los Angeles, CA Department of Computer Science, University of California, Los Angeles, Los Angeles, CAView Profile Authors Info & Claims SAC '01: Proceedings of the 2001 ACM symposium on Applied computingMarch 2001 Pages 248–252https://doi.org/10.1145/372202.372334Published:01 March 2001Publication History 84citation438DownloadsMetricsTotal Citations84Total Downloads438Last 12 Months17Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Automated daily human activity recognition for video surveillance using neural network (2017)

Surveillance video systems are gaining increasing attention in the field of computer vision due to its demands of users for the seek of security. It is promising to observe the human movement and predict such kind of sense of movements. The need arises to develop a surveillance system that capable to overcome the shortcoming of depending on the human resource to stay monitoring, observing the normal and suspect event all the time without any absent mind and to facilitate the control of huge surveillance system network. In this paper, an intelligent human activity system recognition is developed. Series of digital image processing techniques were used in each stage of the proposed system, such as background subtraction, binarization, and morphological operation. A robust neural network was built based on the human activities features database, which was extracted from the frame sequences. Multi-layer feed forward perceptron network used to classify the activities model in the dataset. The classification results show a high performance in all of the stages of training, testing and validation. Finally, these results lead to achieving a promising performance in the activity recognition rate.
Clinical potential, safety, and tolerability of arbaclofen in the treatment of autism spectrum disorder (2014)

Autism spectrum disorder (ASD) is a behaviorally defined disorder which has increased in prevalence over the last two decades. Despite decades of research, no effective treatment is currently available. Animal models, as well as other lines of evidence, point to abnormalities in the balance of cortical excitation to inhibition in individuals with ASD, with this imbalance resulting in an overall increase in cortical excitation. To reduce cortical excitatory glutamate pathways, arbaclofen, a selective agonist of the gamma aminobutyric acid receptor type B, has been developed. This article reviews the evidence for this treatment for ASD using a systematic review methodology. Overall, a systematic search of the literature revealed 148 relevant references with the majority of these being review papers or news items that mentioned the potential promise of arbaclofen. Five original studies were identified, four of which used STX209, a form of arbaclofen developed by Seaside Therapeutics, Inc., and one which used R-baclofen. In an animal model, treatment of Fragile X, a genetic disease with ASD features, demonstrated a reversal of behavioral, neurological, and neuropathological features associated with the disease. One double-blind, placebo-controlled study treated children and adults with Fragile X. Results from this study were promising, with signs of improvement in social function, especially in the most severely socially impaired. Two studies, one open-label and one double-blind, placebo-controlled, were conducted in children, adolescents, and young adults with ASD. These studies suggested some improvements in socialization, although the effects were limited and may have been driven by individuals with ASD that were higher-functioning. These studies and others that have used arbaclofen for the treatment of gastroesophageal reflux suggest that arbaclofen is safe and well-tolerated. Clearly, further clinical studies are needed in order to refine the symptoms and characteristics of children with ASD that are best treated with arbaclofen.
Zipper Codes: Spatially-Coupled Product-Like Codes with Iterative Algebraic Decoding (2019)

We introduce zipper codes, a new framework for describing spatially-coupled product-like codes. This framework consists of a zipping pair, an interleaver map, and a constituent code. Some constructions of well-known codes can be represented in this framework. Simulation results show that a rate 0.98 tiled diagonal zipper code with a triple-error-correcting constituent code can achieve 0.49 dB gap from capacity.
Beyond Mapping: Concepts, Algorithms, and Issues in Gis (1993)

Maps as Data and Data Structure Implications. Measuring Effective Distance and Connectivity. Roving Windows: Assessment of Neighborhood Characteristics. What GIS Is and Isn't: Spatial Data Mapping, Management, Modeling, and More. Assessing Variability, Shape, and Pattern of Map Features. Overlaying Maps and Characterizing Error Propagation. Overlaying Maps and Summarizing the Results. Scoping GIS: What to Consider. Slope, Distance, and Connectivity: Their Algorithms. Cartographic and Spatial Modeling. Epilog. Appendices. Glossary. Index.
Transfer Reactions Involving Boron. X. The Stereochemistry of Eliminations Involving β-Substituted Organoboranes<sup>1,2</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransfer Reactions Involving Boron. X. The Stereochemistry of Eliminations Involving β-Substituted Organoboranes1,2Daniel J. Pasto and Sr. Ricella Snyder O.S.F.Cite this: J. Org. Chem. 1966, 31, 9, 2777–2784Publication Date (Print):September 1, 1966Publication History Published online1 May 2002Published inissue 1 September 1966https://pubs.acs.org/doi/10.1021/jo01347a012https://doi.org/10.1021/jo01347a012research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Diameters of the Retinal Vessels in Diabetic and Normal Subjects (1969)

The diameters of the retinal veins and arteries have been measured on photographs of the retina of 346 juvenile diabetic and 147 normal subjects. Statistical analysis of data was made from the findings in 266 diabetic and 129 normal subjects. The mean width of the retinal veins in the diabetic group was about 10 per cent greater than that of the normal group (p &lt; 0.001). About 8 per cent of the diabetic patients had vein diameters outside the normal range. The arteries of the diabetic patients were dilated on the average about 5 per cent (p &gt; 0.001). There was a weak correlation between the known duration of the diabetes and the vein diameter. The average vein diameter was highest in patients with retinopathy. From an analysis of the relationship between duration of diabetes and the occurrence of the retinopathy and vein dilatation it is concluded that vein dilatation is not a particularly early phenomenon in the development of the diabetic retinopathy, but rather an integrated part of the retinopathy.
A user interface for interactive cinematic shadow design (2002)

Placing shadows is difficult task since shadows depend on the relative positions of lights and objects in an unintuitive manner. To simplify the task of the modeler, we present a user interface for designing shadows in 3d environments. In our interface, shadows are treated as first-class modeling primitives just like objects and lights. To transform a shadow, the user can simply move, rescale or rotate the shadow as if it was a 2d object on the scene's surfaces.When the user transforms a shadow, the system moves lights or objects in the scene as required and updates the shadows in realtime during mouse movement. To facilitate interaction, the user can also specify constraints that the shadows must obey, such as never casting a shadow on the face of a character. These constraints are then verified in real-time, limiting mouse movement when necessary. We also integrate in our interface fake shadows typically used in computer animation. This allows the user to draw shadowed and non-shadowed regions directly on surfaces in the scene.
Analysis and Performance Measurement of Axial Vortex Separator (SVA) for Liquids/Gas Mixture (2011)

Abstract Nowadays, the efficient separation of multiphase mixtures has a great importance in offshore installations where space is limited. In this case, the use of Compact Cyclonic Separators (CCS) has gained popularity because it is simple, compact, and economical to manufacture and operate. Its operation field is established on the basis of superficial velocities of liquid and gas within the separator, being limited by the occurrence of two phenomena: the Liquid Carry-Over (LCO) and the Gas Carry-Under (GCU) in the discharge pipes of gas and liquid respectively. Taking into account this two main phenomena, in the present experimental study was determined the operation field and performance of an Axial Vortex Separator (SVA) of 3’’ in diameter for a water-air mixture flow. SVA is composed by two vertical concentric tubes. The inner tube has a stator to generate a vortex centrifugal force which combined together with the buoyancy and gravity forces can separate the phases. SVA behavior was studied for different relative positions of the concentric tubes and two different angles from the stator blades. The experimental results were used to analyze the accuracy of mechanistic models available in literature for prediction of LCO and the flow patterns presented in the SVA. A good agreement was accomplished. Additionally, the operational envelope of SVA with 0% and 1% of LCO was determined. The SVA minimum separation efficiency in the experimental tests carried out was 99%.
NOS2 and CCL27: clinical implications for psoriasis and eczema diagnosis and management (2014)

Chronic inflammatory skin diseases such as psoriasis and eczema are a major medical challenge. Development of highly specific therapies for both conditions is opposed by the lack of translation of basic knowledge into biomarkers for clinical use. Furthermore, to distinguish psoriasis from eczema might be difficult occasionally, but specific and costly therapies would not be efficient in misdiagnosed patients. In the era of high-throughput 'omics'-technologies, comparing the molecular signature of psoriasis and eczema is a promising approach to gain insight into their complex pathogeneses and develop new diagnostic and therapeutic strategies. Investigating patients affected by both psoriasis and eczema simultaneously, we recently constructed a disease classifier consisting of only two genes (NOS2 and CCL27) that reliably predicts the correct diagnosis even in clinically unclear cases. When such easy-to-handle approaches are combined with individual therapeutic response, we might reach the ultimate goal of personalized medicine in inflammatory skin diseases in near future.
Study of Thermal Decomposition of Li<sub>1‐x</sub>(Ni<sub>1/3</sub>Mn<sub>1/3</sub>Co<sub>1/3</sub>)<sub>0.9</sub>O<sub>2</sub> Using In‐Situ High‐Energy X‐Ray Diffraction (2013)

Abstract Safety has been a major technological concern hindering the deployment of lithium‐ion batteries for automobile applications. We investigated the decomposition mechanism of delithiated cathode materials at thermal abuse conditions using Li 1.1 [Ni 1/3 Mn 1/3 Co 1/3 ] 0.9 O 2 as a model cathode material. An in‐situ high‐energy X‐ray diffraction technique was established as an alternative to conventional thermal analysis techniques like differential scanning calorimetry and accelerating rate calorimetry. The X‐ray diffraction data revealed that the thermal decomposition pathway of delithiated Li 1‐x [Ni 1/3 Mn 1/3 Co 1/3 ] 0.9 O 2 strongly depended on the exposed chemical environment, like solvents and lithium salts. A phase transformation of dry delithiated Li 1‐x [Ni 1/3 Mn 1/3 Co 1/3 ] 0.9 O 2 was observed at about 278 °C, and its onset temperature was reduced to about 197°C with the presence of the electrolyte. It is suggested that the reduction in thermal stability is possibly related to proton intercalation into the delithiated material.
2010년 한국어교육 국제학술회의 : 다문화 시대의 문학과 대중문화 ; 시집살이 노래 수용에서 공감의 양상 연구 -결혼 이주 여성을 대상으로 (2010)

본고는 결혼 이주 여성을 대상으로 한 문학 교육의 내용과 방법 설계를 위한 기초 연구로써 문학 수용의 한 원리로 작용하는 공감에 주목하고 실제 학습자의 공감의 양상을 살펴 그 의의를 밝히고자 했다. 이를 위해 구체적인 문학 자료로 시집살이 노래를 결혼 이주 여성들에게 제시하고, 실제의 교실 수업을 통해 감상문을 수집하고 분석하였는데 공감의 양상은 다음의 세 가지로 정리할 수 있었다. 첫째, 결혼 이주 여성들은 작품의 화자를 학습자 자신과 동일한 실재적 존재로 인식하였다. 노래 속 화자의 정서를 학습자 자신 안에서 재현함으로써 대상의 정서를 실제적으로 느끼고 일치를 이루는 공감의 양상을 보였다. 둘째, 결혼 이주 여성들은 타자(他者) 체험의 자기화 욕구를 표현하였다. 노래 속의 화자의 체험에 지지(支持)를 표하면서 독자 자신이 그 체험에 참여하고 나아가 자기화(自己化)하고자 하는 의지를 드러냈다. 셋째, 결혼 이주 여성들은 타자 체험에 대한 거리감을 유지하였다. 작품 속의 화자를 타자로 인식하면서 타자의 상황을 관조하고 타자의 정서적 체험을 심화시켜 자신의 경험과 가치로 인식하는 감상 혹은 비평 활동을 수행하는 양상을 보였다.
Proximal Junctional Kyphosis and Failure After Spinal Deformity Surgery (2014)

N/A.
Detecting and decomposing self-overlapping curves (1989)

Paint one side of a rubber disk black and the other side white; stretch the disk any way you wish in three-dimensional space, subject to the condition that from any point in space, if you look down you see either the white side of the disk or nothing at all. Now make the stretched disk transparent but color its boundary black; project its boundary into a plane that lies below the disk. The resulting curve is self-overlapping. We show how to test whether a given curve is self-overlapping, and how to count how many essentially different stretchings of the disk could give rise to the same curve.
Measurement reliability and agreement in psychiatry (1998)

Psychiatric research has benefited from attention to measurement theories of reliability, and reliability/agreement statistics for psychopathology ratings and diagnoses are regularly reported in empirical reports. Nevertheless, there are still controversies regarding how reliability should be measured, and the amount of resources that should be spent on studying measurement quality in research programs. These issues are discussed in the context of recent theoretical and technical contributions to the statistical analysis of reliability. Special attention is paid to statistical studies published since Kraemer's 1992 review of reliability methods in this journal.
A Novel Alicyclic Polymers for 193nm Single Layer Resist Materials. (1998)

Recently reported ArF positive photoresists can be classified into three groups: derivative methacrylate copolymers (methacrylate resist), methacrylate copolymers functionalized with pendant alicyclic moieties (alicyclic resist), and cycloolefin-maleic anhydride copolymers (cycloolefin resist). Each system has its own advantages and drawbacks in the viewpoint of lithographic properties.Methacrylate resists have been used for the assessment of ArF lens performance. However, it is hard to apply them in real device process because of their low plasma-etch resistance. Previous studies have reported that alicyclic resists possess adequate etch resistance with the help of cyclic carbon units, however these resists show poor adhesion and seldom dissolve in 2.38% TMAH developer. The cycloolefin resists will be good candidate for addressing the trade-off between etch resistance and requisite material properties for lithographic performance because these resists, unlike methacrylate-based resists, contain large quantities of alicyclic structures directly in the polymer backbone and such properties as dissolution and adhesion can be readily controlled by incorporation of -COOH and -OH functional groups into cycloolefin structures.We have synthesized poly(2-hydroxyethyl 5-norbornene-2-carboxylate / t-butyl 5-norbornene-2-carboxylate / 5-norbornene-2-carboxylic acid / maleic anhydride; HNC / BNC / NC / MA) resists with a variety of functional groups and obtained lithographic performance by using ArF stepper(0.6NA). In this paper, we will describe the basic idea for designing of the novel cycloolefin resist and demonstrate lithographic capabilities, especially in terms of process window for 130nm feature. In addition, the etch resistance of this resist will be shown. We believe that off-axis illumination should be applied to 130nm device technology to obtain wider process window