gebhart/patrepeval huggingface dataset:
JAB1/CSN5: a new player in cell cycle control and cancer (2010)

c-Jun activation domain-binding protein-1 (Jab1) acts as a modulator of intracellular signaling and affects cellular proliferation and apoptosis, through its existence as a monomer or as the fifth component of the constitutive photomorphogenic-9 signalosome (CSN5). Jab1/CSN5 is involved in transcription factor specificity, deneddylation of NEDD8, and nuclear-to-cytoplasmic shuttling of key molecules. Jab1/CSN5 activities positively and negatively affect a number of pathways, including integrin signaling, cell cycle control, and apoptosis. Also, more recent studies have demonstrated the intriguing roles of Jab1/CSN5 in regulating genomic instability and DNA repair. The effects of Jab1/CSN5's multiple protein interactions are generally oncogenic in nature, and overexpression of Jab1/CSN5 in cancer provides evidence that it is involved in the tumorigenic process. In this review, we highlight our current knowledge of Jab1/CSN5 function and the recent discoveries in dissecting the Jab1 signaling pathway. Further, we also discuss the regulation of Jab1/CSN5 in cancers and its potential as a therapeutic target.
Location and Positioning Systems: Performance and comparison (2016)

In the age of automation the ability to navigate persons and devices in indoor/outdoor environments has become important for many applications. With the apparition of the Global satellite Positioning Systems (GPS), the performance of outdoor positioning provide good location estimates and provide high accuracy rate. But, they cannot be used in indoor environments due to the weakness of their signals in the lack of line of sight between the GPS satellites and the receiver Mobile Station. Therefore, indoor positioning systems need alternative means to detect the Mobile Station's location without counting on the direct radio frequency signal from GPS satellites. In this paper we are interested on the local positioning Systems (LPS), which are an extension of the GPS in the absence of GPS covering, in close spaces. So we are presenting a revision of the Location and Positioning System (LPS), techniques, algorithms and characteristics, and finally a comparison between the Geometric and Gauss-Newton method to select the accurate one.
Lineage ambiguity in acute leukemia (1986)

Two cases of acute nonlymphocytic leukemia that showed surface phenotypes characteristic of lymphoid cells are reported. The cases, both involving female patients were studied by a variety of methods including flow cytometry and karyotyping. In Case 1, the patient, a 10-year-old girl, had poorly differentiated myeloblasts (FAB M1), which were weakly positive for Sudan black B (SBB), but negative for alpha naphthyl acetate esterase (NAE) and naphthol ASD chloroacetate esterase (CAE). Myeloperoxidase was demonstrated ultrastructurally in some of the blasts. In Case 2, the 30-year-old patient had typical myelomonocytic leukemia (FAB M4), with SBB-, NAE-, and CAE-positive blasts. Both cases were negative for terminal deoxynucleotidyl transferase. Case 1 was negative for myeloid membrane markers, whereas Case 2 was strongly positive for My7 and My9. Surprisingly, both cases showed significant positivity for B-cell restricted antigens B1, B2, and B4. These findings suggest ambiguous or dual lineage, supporting the concepts that some leukemias could arise from a pluripotent hematopoietic progenitor cell (Case 1) or from cells that though differentiated in some respects, could still preserve some early antigens (Case 2).
Temperature-scanned magnetic resonance and the evidence of two-way transfer of a nitrogen nuclear spin hyperfine interaction in coupled NV-N pairs in diamond (2012)

New method for the detection of magnetic resonance signals versus temperature is developed on the basis of the temperature dependence of the spin Hamiltonian parameters of the paramagnetic system under investigation. The implementation of this technique is demonstrated on the nitrogen-vacancy (NV) centers in diamonds. Single NV defects and their ensembles are suggested to be almost inertialess temperature sensors. The hyperfine structure of the 14N nitrogen nuclei of the nitrogen-vacancy center appears to be resolved in the hyperfine structure characteristic of the hyperfine interaction between NV and an N s center (substitutional nitrogen impurity) in the optically detected magnetic resonance spectra of the molecular NV-N s complex. Thus, we show that a direct evidence of the two-way transfer of a nitrogen nuclear spin hyperfine interaction in coupled NV-N s pairs was observed. It is shown that more than 3-fold enhancement of the NV optically detected magnetic resonance signal can be achieved by using water as a collection optics medium.
Ferroelectric liquid crystal gels Network stabilized ferroelectric display (1995)

Abstract Liquid crystal (LC) mixtures of a reactive diacrylate and a commercial ferroelectric liquid crystal (FLC) mixture were produced. The mixtures were brought into cells provided with orientation layers in which various orientations such as uniaxial and twisted orientations, could be induced. When the desired orientation had been obtained, the polymerization of the reactive molecules was induced creating a three-dimensional anisotropic network containing the FLC molecules which were not chemically attached to the network (ferroelectric gels). The presence of the anisotropic network was found to have a large effect on various properties of the FLC molecules. For example, complex orientations (for example, 180° twisted) obtained by polymerization (formation of the gel) in the nematic phase remained unchanged when the gel was cooled to the FLC phase. Likewise uniaxial orientation, which cannot be realised in thick cells containing the pure FLC, could be realised when ferroelectric gels were used. For this reason the ferroelectric gels will be referred to as an anisotropic network-stabilized FLC. Optical properties such as effective birefringence and tilt angle were also influenced by the network. When use was made of a network with a lower birefringence than the FLC, a reduced effective birefringence in gels was observed. This is important for technologies involving thicker cells. The switching covered a range of voltages in the case of the gels, instead of showing a well-defined threshold voltage as in the bulk. The possibility of using this effect to obtain grey scales in cells during passive addressing has also been demonstrated.
Optimality conditions for the bilevel programming problem (1984)

Abstract The bilevel programming problem (BLPP) is a sequence of two optimization problems where the constraint region of the first is determined implicitly by the solution to the second. In this article it is first shown that the linear BLPP is equivalent to maximizing a linear function over a feasible region comprised of connected faces and edges of the original polyhedral constraint set. The solution is shown to occur at a vertex of that set. Next, under assumptions of differentiability, first‐order necessary optimality conditions are developed for the more general BLPP, and a potentially equivalent mathematical program is formulated. Finally, the relationship between the solution to this problem and Pareto optimality is discussed and a number of examples given.
Muscle relaxants for pain management in rheumatoid arthritis (2011)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The objectives of this systematic review are to: evaluate the analgesic effectiveness of muscle relaxants in patients with RA; assess whether any analgesic effect is independent of improved sleep or mood; and evaluate the adverse events reported in the clinical trials
Observing local and global properties of metabolic pathways: ‘load points’ and ‘choke points’ in the metabolic networks (2006)

The load and choke point modules are introduced in the Pathway Hunter Tool (PHT), the basic version of which is available on http://www.pht.uni-koeln.de.
Optimal Strategies for Divestiture (1969)

This paper examines a class of optional stopping problems in the context of the divestiture of an asset by a business or an individual. It first describes and analyzes a simple version of the problem, and then considers various generalizations, which are reduced to modified versions of the original problem. Next, it examines a heuristic procedure for obtaining approximate solutions, together with an analysis of the sensitivity of the criterion to a nonoptimal decision rule. Finally, it discusses the effect of a nonstationary environment on the divestiture strategy.
The Banker's Acceptance: An Examination and Analysis of the Instrument and Market (1980)

The purpose of this dissertation is to examine and analyze the banker's acceptance and the bankers' acceptance market. A banker's acceptance is a money market instrument used to finance the export, import, movement, and storage of goods; it begins as a trade draft, and it is termed accepted when a commercial bank guarantees payment. The banker's acceptance represents an historical evolution of the medieval bill of exchange. The banker's acceptance as we know it today first appeared in England in the 1820s. The birth of the banker's acceptance in the United States occurred with passage of the Federal Reserve Act in 1913. A survey was made of the twenty largest U.S. commercial banks in order to determine certain perceived characteristics of the banker's acceptance and the bankers' acceptance market. As a result of the survey, a new money market instrument is suggested. The new money market instrument is to be called a Banker's Acceptance Participation Certificate.
The over-bump applied resin wafer-level underfill process: Process, material and reliability (2009)

The over bump applied resin (OBAR) process is a wafer-level underfill (WLUF) process in which a filled resin is applied over the bumps of a wafer and, dried. The wafer is diced into coated chips which are aligned and joined to a substrate resulting in an underfilled flip chip package. This process has been evaluated by IBM on several test vehicles in close cooperation with Henkel (formerly Abelstik) who developed a material specifically to fit this process. The critical steps to make this technology work are alignment of OBAR coated chip to a substrate, elimination of significant voids, formation of a fillet with appropriate shape and size, fluxing and solder joining. The reliability of the material was evaluated after capping and BGA (Ball Grid Array) attach through JEDEC level 3 preconditioning followed by DTC (deep thermal cycling), T&H (temperature and humidity), and HTS (high temperature storage). While some improvements are still needed, the OBAR process has been shown to be a viable alternative to capillary underfill application.
Multi-perspective Machine Learning (MPML) — A Machine Learning Model for Multi-faceted Learning Problems (2017)

Machine learning has been applied to various learning problems across a number of disciplines. The availability of data, algorithms and the success of machine learning methods has made machine learning a popular choice for analyzing and solving big data problems. In this paper, we propose a novel machine learning model based on ensemble learning, feature method pairs and multi-view learning concepts. This model targets learning problems with multiple factors or facets. Using botnet detection as an example multi-faceted learning problem, we explain the desirable properties this model promises. The aim of the model is to provide a guideline for designing machine learning based solutions for a specific type of learning problem.
Tracking sub-micron fluorescent particles in three dimensions with a microscope objective under non-design optical conditions (2006)

A microscope objective designed for air medium has been used under non-design optical conditions to focus an exciting laser beam on sub-micron fluorescent particles with the emitted fluorescence received through a glass layer with a mismatched refractive index. The diffraction pattern with several clear interference fringes generated from the fluorescence emitted from a fluorescent particle changed with the particle's position along the optical axis. A scalar diffraction model developed by Gibson and Lanni (1991 J. Opt. Soc. Am. A 8 1601–13) was used to predict the diffraction patterns for various aberration conditions and to analyse the effects of the coherence properties of the fluorescence on the details of the diffraction pattern. The particle position along the optical axis, i.e. its defocus distance, could be determined based on the characteristic sizes of the particle's diffraction pattern to track the particle in three dimensions.
Detection of hydrogen chloride gas in ambient air with a coated piezoelectric quartz crystal (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetection of hydrogen chloride gas in ambient air with a coated piezoelectric quartz crystalJ. Hlavay and G. G. GuilbaultCite this: Anal. Chem. 1978, 50, 7, 965–967Publication Date (Print):June 1, 1978Publication History Published online1 May 2002Published inissue 1 June 1978https://pubs.acs.org/doi/10.1021/ac50029a035https://doi.org/10.1021/ac50029a035research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Switch in Retrograde Signaling from Survival to Stress in Rapid-Onset Neurodegeneration (2009)

Retrograde axonal transport of cellular signals driven by dynein is vital for neuronal survival. Mouse models with defects in the retrograde transport machinery, including the Loa mouse (point mutation in dynein) and the Tg(dynamitin) mouse (overexpression of dynamitin), exhibit mild neurodegenerative disease. Transport defects have also been observed in more rapidly progressive neurodegeneration, such as that observed in the SOD1(G93A) transgenic mouse model for familial amyotrophic lateral sclerosis (ALS). Here, we test the hypothesis that alterations in retrograde signaling lead to neurodegeneration. In vivo, in vitro, and live-cell imaging motility assays show misregulation of transport and inhibition of retrograde signaling in the SOD1(G93A) model. However, similar inhibition is also seen in the Loa and Tg(dynamitin) mouse models. Thus, slowing of retrograde signaling leads only to mild degeneration and cannot explain ALS etiology. To further pursue this question, we used a proteomics approach to investigate dynein-associated retrograde signaling. These data indicate a significant decrease in retrograde survival factors, including P-Trk (phospho-Trk) and P-Erk1/2, and an increase in retrograde stress factor signaling, including P-JNK (phosphorylated c-Jun N-terminal kinase), caspase-8, and p75(NTR) cleavage fragment in the SOD1(G93A) model; similar changes are not seen in the Loa mouse. Cocultures of motor neurons and glia expressing mutant SOD1 (mSOD1) in compartmentalized chambers indicate that inhibition of retrograde stress signaling is sufficient to block activation of cellular stress pathways and to rescue motor neurons from mSOD1-induced toxicity. Hence, a shift from survival-promoting to death-promoting retrograde signaling may be key to the rapid onset of neurodegeneration seen in ALS.
Role of Abscisic Acid in the Induction of Desiccation Tolerance in Developing Seeds of <i>Arabidopsis thaliana</i> (1992)

In contrast to wild-type seeds of Arabidopsis thaliana and to seeds deficient in (aba) or insensitive to (abi3) abscisic acid (ABA), maturing seeds of recombinant (aba,abi3) plants fail to desiccate, remain green, and lose viability upon drying. These double-mutant seeds acquire only low levels of the major storage proteins and are deficient in several low mol wt polypeptides, both soluble and bound, and some of which are heat stable. A major heat-stable glycoprotein of more than 100 kilodaltons behaves similarly; during seed development, it shows a decrease in size associated with the abi3 mutation. In seeds of the double mutant from 14 to 20 days after pollination, the low amounts of various maturation-specific proteins disappear and many higher mol wt proteins similar to those occurring during germination are induced, but no visible germination is apparent. It appears that in the aba,abi3 double mutant seed development is not completed and the program for seed germination is initiated prematurely in the absence of substances protective against dehydration. Seeds may be made desiccation tolerant by watering the plants with the ABA analog LAB 173711 or by imbibition of isolated immature seeds, 11 to 15 days after pollination, with ABA and sucrose. Whereas sucrose stimulates germination and may protect dehydration-sensitive structures from desiccation damage, ABA inhibits precocious germination and is required to complete the program for seed maturation and the associated development of desiccation tolerance.
Understanding the Energy Consumption of Dynamic Random Access Memories (2010)

Energy consumption has become a major constraint on the capabilities of computer systems. In large systems the energy consumed by Dynamic Random Access Memories (DRAM) is a significant part of the total energy consumption. It is possible to calculate the energy consumption of currently available DRAMs from their datasheets, but datasheets don't allow extrapolation to future DRAM technologies and don't show how other changes like increasing bandwidth requirements change DRAM energy consumption. This paper first presents a flexible DRAM power model which uses a description of DRAM architecture, technology and operation to calculate power usage and verifies it against datasheet values. Then the model is used together with assumptions about the DRAM roadmap to extrapolate DRAM energy consumption to future DRAM generations. Using this model we evaluate some of the proposed DRAM power reduction schemes.
Taxonomy of Data Prefetching for Multicore ProcessorsTaxonomy of Data Prefetching for Multicore Processors (2009)

预取的数据是隐藏技术掩盖缓存失误引起的中央处理器货摊并且衔接在处理器和存储器之间的性能差距的有效数据存取潜伏。与硬件或软件支持，在它实际上被需要以前，预取的数据更近把数据带到一个处理器。许多预取的技术为单个核心的处理器被开发了。在处理器技术的最近的开发多把核心处理器带进主流。当一些单个核心的预取技术对直接适用时多核心处理器，众多的新奇策略在过去几年里被建议了利用多重核心。这篇论文多试图提供最先进的预取技术的全面评论，并且建议在开发预取的策略分类各种各样的设计担心的一个分类，为特别核心处理器。我们也通过分析比较各种各样的存在方法。
ChemInform Abstract: SUBSTITUTED ALKYL SULFONATES BY ADDITION OF SODIUM HYDROGEN SULFIDE TO CHALCONES (1980)

Abstract Durch Addition von NaHSO 3 an die C,C‐Doppelbindung der Chalkone (I) werden in guten Ausb. die Sulfonate (II) erhalten.
Auf der Suche nach Mr. Miyagi (2019)

Der Mensch, der als einziges Wesen um seine Endlichkeit weiß, sucht nach Hilfen, um mit eben dieser Gewissheit leben zu können. In den Kampfkünsten, die symbolisch für diese Spannung zwischen Leben und Tod stehen, wird dies durch den Meister/Lehrer möglich, der als eine Art „Wegweiser“ fungiert. Am Film „Karate Kid“ wird dies verdeutlicht.
Monosaccharide mit Stickstoff im Ring, XXXIX. Synthese von modifizierten α‐<scp>L</scp>‐Fucosidase‐Inhibitoren, die 1,5‐Didesoxy‐1,5‐imino‐<scp>L</scp>‐fucit als Basisstruktur enthalten (1990)

Monosaccharides Containing Nitrogen in the Ring, XXXIX. — Synthesis of Analogues of 1,5‐Dideoxy‐1,5‐imino‐ L ‐fucitol, Inhibitors of α‐ L ‐Fucosidase Variation of the side chain in the 1,3‐dithiane derivative 1 of D ‐galactose leads to a series of analogues of 1,5‐dideoxy‐1,5‐imino‐ L ‐fucitol (deoxyfuconojirimycin) ( 33 ), which are potent inhibitors of α‐ L ‐fucosidase. Cleavage of the dithioacetal in 5 followed by reduction of the aldehyde 6 and deblocking results in 1,5‐dideoxy‐1,5‐imino‐ L ‐galactitol ( 8 ). The aldehyde 6 is converted by Wittig reaction to 10 and 14 via 9 and 13 , which are homologues of 1,5‐dideoxy‐1,5‐imino‐ L ‐fucitol ( 33 ). Cyclization of the Wittig product 15 yields the γ‐lactam 18 . After reduction of the acetylated γ‐lactam 19 and subsequent deblocking the trihydroxyindolizidine 24 is obtained, which is an analogue of castanospermine with L ‐ fuco configuration. The chloride 30 , which is available from 27 , can be converted by intramolecular substitution and removal of the blocking groups to the bicyclic aziridine derivative (3 R ,4 S ,5 R ,6 S ) ‐1‐azabicyclo[4.1.0]heptane‐3,4,5‐triol ( 32 ). First results on the inhibitory activities of all new analogues on α‐ L ‐fucosidase are presented.
Waveguide Capillary Cell for Low-Refractive-Index Liquids (1997)

We describe a waveguide capillary cell based on a fused-silica tube coated externally with a thin layer of a low-refractive-index ( n = 1.31) fluoropolymer. When filled with a transparent liquid of refractive index greater than that of the fluoropolymer, the cell is capable of transmitting light through total internal reflection. Loss below 1 dB/m is demonstrated throughout much of the visible region for a 530-μm-i.d., 660-μm-o.d. cell filled with water.
Herpes Simplex Viruses in Antiviral Drug Discovery (2006)

Since the 1950's, herpes simplex viruses (HSV) have played prominent roles in the development of antivirals. The first efficacious antivirals, as well as the first safe for systemic use, were developed against HSV. It was only in 1995 when the first antiviral against a target not validated first with HSV was approved for clinical use (sequinavir). The early successes of targeting HSV DNA replication were most influential in developing the concept that antiviral drugs must target viral proteins. Such concept has ensured the safety of current antiviral drugs, which all target viral proteins. Current antivirals have proven to have no major negative effects on non-infected cells or treated patients. Because of their success widespread and use, however, these drugs have been found to have some limitations. Perhaps the clinically most important one is their ability to promptly select for drug-resistant viral strains. Owing to such limitations, cellular proteins are now considered as valid targets for novel antiviral drugs. The discovery that pharmacological CDK inhibitors (PCIs) inhibit HSV replication through novel mechanisms played a major role in this new appreciation of cellular proteins as potential targets for antivirals. This appreciation is reflected in the scheduling of PCIs to enter clinical trials as antivirals (against HIV). Herein, we will review the roles of HSV as model viruses in the discovery and development of antiviral drugs. The major focus will be on the recent discovery on the activities of PCIs against HSV and other viruses.