gebhart/patrepeval huggingface dataset:
Possible Mechanisms by which Combustion-Chamber Deposits Accumulate and Influence Knock (1951)

<div class="section abstract"><div class="htmlview paragraph">THREE mechanisms by which combustion-chamber deposits might increase the octane requirement of an engine are discussed in this paper. These are volume, catalysis, thermal insulation.</div><div class="htmlview paragraph">The experiments reported here indicate that the increase in compression ratio caused by deposit volume accounts, for 20-40% of the octane requirement increase, catalysis may not be a contributing factor, and the thermal insulating effect of the deposits is one of the major causes of deposit knocking harm.</div></div>
Integrating through-silicon vias with solder free, compliant interconnects for novel, large area interposers (2012)

A novel packaging module is described that is based on co-integration of flexible micro-spring interconnects with through silicon copper vias (TSVs) into a passive large area silicon interposer. We report on the packaging test vehicles based on such interposers that are designed to demonstrate a wafer scale integration process to form TSV+spring interconnects with high yield and low resistance. Our goal is to develop a scalable, large area die or MCM packaging platform to enable stress-free, readily reworkable packaging of chips and components with different functionality and technology. We show interposer layouts, share process details and characterization methods.
Research and development of a charged-particle bipolar thruster. (1969)

acceleration due to gravity i = TOF collector current io = TOF collector current at t = 0 ic = collector current IE = extractor current in = emitter current /Sp = specific impulse, sec q/m = specific charge, coul/kg (q/m) = mean specific charge ((g/m)1/2)2 = square mean root specific charge €» = {(q/m)ll2)2/(q/m), specific charge efficiency V =
Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. I. Significant variation in repertoire expression between individual mice (1983)

The paratypic and idiotypic diversity of the BALB/c antibody response to the hemagglutinin (HA) of the influenza A/PR/8/34 virus (PR8) was investigated using a panel of 125 anti-HA hybridoma antibodies derived from 14 BALB/c mice. The paratypic diversity, as assessed by a fine specificity analysis using 51 related influenza viruses, was extensive: 104 distinct paratopes were observed. In three instances, antibodies with indistinguishable paratopes were isolated from two individual mice. A minimum estimate of the size of the adult BALB/c anti-HA paratypic repertoire, calculated from these data, is 1,500. The generation of this diverse repertoire was studied by screening the anti-HA hybridoma panel for the presence of idiotypes (Id) that are markers for variable (V) region sequences derived from related germ line V genes. Three cross-reactive Id (IdX) that are markers for the V(k)21C, V(k)21B, and V(k)21A, D, E, or F L chain subgroups were found, respectively on 16, 1, and 10 anti-HA hybridoma antibodies derived from seven individual BALB/c mice. Thus, the V(k)21 IdX(+) hybridomas constitute 22 percent of the anti-HA hybridoma panel. The V(k)21 IdX are also present on 8.6 percent of K-bearing immunoglobulin in normal BALB/c serum. This suggests that the V(k)21 group is used preferentially in the BALB/c anti-HA immune response. The generation of the anti-HA repertoire was further studied using large panels of anti-HA hybridomas derived from two individual adult BALB/c mice. Anti-idiotypic antisera were raised in rabbits against individual hybridomas from each mouse. One anti-Id serum defined a family of four idiotypically and paratypically related, but not identical, antibodies from mouse 36, which represented 31 percent of the hybridoma antibodies isolated from this mouse. None of the 112 anti-HA hybridoma antibodies derived from 13 other individual mice showed idiotypic cross-reactivity. Furthermore, this Id could not be detected in anti-PR8 antisera from 75 individual BALB/c mice. Another anti-Id serum defined a family of 27 idiotypically related antibodies from mouse 37, which represented 50 percent of the hybridoma antibodies isolated from this mouse. Only 1 of the 71 hybridoma antibodies isolated from 13 other individuals was idiotypically cross-reactive. These results demonstrate that individual adult BALB/c mice express paratypically and idiotypically distinct antibody repertoires to the HA of influenza virus PR8. Based on these observations, we suggest that somatic mutation plays an important role in the generation of the adult anti-HA repertoire. Mechanisms that could account for differences in repertoire expression among individual mice are discussed.
A Sequence of Palladium-Catalyzed Borylation of Allyl Acetates with Bis(pinacolato)diboron and Intramolecular Allylboration for the Cyclization of Oxo-2-alkenyl Acetates (1997)

Abstract The cross-coupling reaction of bis(pinacolato)diboron with oxo-2-alkenyl acetates in toluene at 50 °C in the presence of Pd(dba)2/2 AsPh3 (3 mol%) to give allylboronates was followed by the intramolecular allylboration at 100 °C. The sequence provided cyclic homoallyl alcohols in high yields.
Are hippocampal lesions sufficient to cause lasting amnesia? (1982)

A 57-year-old woman developed severe generalised amnesia following an embolic stroke. The amnesia persisted until her death nine months later. The left hemisphere had a large infarction of the medial temporal-occipital region, while the right showed only a small infarct limited to the posterior two-thirds of the hippocampus. If bilateral lesions are necessary for the production of permanent amnesia, the findings support the view that the hippocampus is itself a critical structure in the medial temporal diencephalic memory circuit.
Risk factors for uterine fibroids: reduced risk associated with oral contraceptives. (1986)

Risk factors for pathologically confirmed uterine leiomyomas (fibroids) were investigated using data from the Oxford Family Planning Association study, a long term follow up study of women using various methods of contraception. For each of 535 women who had had a fibroid an individual control was selected who matched the patient on age, date of entry into the cohort, and family planning clinic at recruitment and who was alive (and still being followed up) at the date the patient underwent surgery for fibroids. Case-control analysis showed that reproductive experiences were closely linked to development of fibroids. Risk of fibroids decreased consistently with increasing number of term pregnancies; women with five term pregnancies had only a quarter of the risk of women who had had none. Risk also decreased consistently with increasing duration of oral contraceptive use; the risk of fibroids was reduced by some 31% in women who had used oral contraceptives for 10 years. Risk was strongly related to weight: women who weighed under 55 kg had a particularly low risk, and overall the risk rose roughly 21% for each 10 kg increase. Cigarette smoking was associated with a decreased risk of fibroids; smokers of 20 cigarettes a day had a risk roughly two thirds that of non-smokers. These risk factors have all previously been identified as risk factors for endometrial cancer; this strongly suggests that the underlying risk factor is "unopposed" oestrogen.
Cyanide Detoxification by the Cobalamin Precursor Cobinamide (2006)

Cyanide is a highly toxic agent that inhibits mitochondrial cytochrome-c oxidase, thereby depleting cellular ATP. It contributes to smoke inhalation deaths in fires and could be used as a weapon of mass destruction. Cobalamin (vitamin B12) binds cyanide with a relatively high affinity and is used in Europe to treat smoke inhalation victims. Cobinamide, the penultimate compound in cobalamin biosynthesis, binds cyanide with about 10(10) greater affinity than cobalamin, and we found it was several-fold more effective than cobalamin in (i) reversing cyanide inhibition of oxidative phosphorylation in mammalian cells; (ii) rescuing mammalian cells and Drosophila melanogaster from cyanide toxicity; and (iii) reducing cyanide inhibition of Drosophila Malpighian tubule secretion. Cobinamide could be delivered by oral ingestion, inhalation, or injection to Drosophila, and it was as effective when administered up to 5 mins post-cyanide exposure as when given pre-exposure. We conclude that cobinamide is an effective cyanide detoxifying agent that has potential use as a cyanide antidote, both in smoke inhalation victims and in persons exposed to cyanide used as a weapon of mass destruction.
Inhibition of Amyloid Precursor Protein Processing Enhances Gemcitabine-mediated Cytotoxicity in Pancreatic Cancer Cells (2013)

Pancreatic adenocarcinoma or pancreatic cancer is often diagnosed at a very late stage at which point treatment options are minimal. Current chemotherapeutic interventions prolong survival marginally, thereby emphasizing the acute need for better treatment options to effectively manage this disease. Studies from different laboratories have shown that the Alzheimer disease-associated amyloid precursor protein (APP) is overexpressed in various cancers but its significance is not known. Here we sought to determine the role of APP in pancreatic cancer cell survival and proliferation. Our results show that pancreatic cancer cells secrete high levels of sAPPα, the α-secretase cleaved ectodomain fragment of APP, as compared with normal non-cancerous cells. Treatment of cells with batimastat or GI254023X, inhibitors of the α-secretase ADAM10, prevented sAPPα generation and reduced cell survival. Additionally, inhibition of sAPPα significantly reduced anchorage independent growth of the cancer cells. The effect of batimastat on cell survival and colony formation was enhanced when sAPPα downregulation was combined with gemcitabine treatment. Moreover, treatment of batimastat-treated cells with recombinant sAPPα reversed the inhibitory effect of the drug thereby indicating that sAPPα can indeed induce proliferation of cancer cells. Down-regulation of APP and ADAM10 brought about similar results, as did batimastat treatment, thereby confirming that APP processing is important for growth and proliferation of these cells. These results suggest that inhibition of sAPPα generation might enhance the effectiveness of the existing chemotherapeutic regimen for a better outcome.
"Sea Lice" (<i>Lepeophtheirus</i>) and Death of Salmon (1940)

In 1939 Lepeophtheirus salmonis infected salmon entering Moser river, Nova Scotia. Some fish had much of skin in occipital region removed and died some time after entering fresh water. It is suggested that these copepods cause the condition on the top of the salmon's head known as "white spot."
Deep Extractive Desulfurization of Gasoline with <i>x</i>Et<sub>3</sub>NHCl·FeCl<sub>3</sub> Ionic Liquids (2010)

xEt3NHCl·FeCl3 (x = 1.4−1.8) ionic liquids were synthesized by mixing Et3NHCl and anhydrous FeCl3 at 80 °C. These were liquid at room temperature, with low viscosities, and exhibited remarkable abilities in effective desulfurization of thiophene in n-octane and fluid catalytic cracking (FCC) gasoline. Among them, 1.6Et3NHCl·FeCl3 showed the highest sulfur removal. The anionic species FeCl4− existed in 1.6Et3NHCl·FeCl3 ionic liquid, as detected by electrospray ionization−mass spectrometry (ESI−MS), and the ionic liquid was stable in air and moisture. Sulfur-free (<10 mg/L) gasoline could be obtained after extraction twice using an ionic liquid/oil volume ratio of 1. The ionic liquid could be recycled 10 times by distillation with a slight decrease in activity.
REQUEST: A Natural Language Question-Answering System (1976)

Request is an experimental Restricted English QUESTion-answering system that can analyze and answer a variety of English questions, spanning a significant range of syntactic complexity, with respect to a small Fortune-500-type data base. The long-range objective of this work is to explore the possibility of providing nonprogrammers with a convenient and powerful means of accessing information in formatted data bases without having to learn a formal query language. To address the somewhat conflicting requirements of understandability for the machine and maximum naturalness for the user, request uses a language processing approach featuring: 1) the use of restricted English; 2) a two-phase, complier-like organization; and 3) linguistic analysis based on a transformational grammar. The present paper explores the motivation for this approach in some detail and also describes the organization, operation, and current status of the system.
Mechanical Strength and Interface Characteristics of Transmission Laser Bonding (2006)

A laser-based bonding technique, called transmission laser bonding (TLB), is studied for the purposes of device and wafer-level packaging. The TLB technique uses the specific characteristics of a laser to bond a transparent wafer on top of an opaque wafer. When a laser beam with a specific wavelength is passed through a transparent wafer, high-density laser energy is absorbed by the opaque wafer and melts a thin surface layer, resulting in the formation of strong chemical bonds across the two wafers. A Nd:YAG pulse laser has been used to bond a transparent glass wafer to a Si substrate. The associated bond strengths under various bonding conditions are examined by a microtensile tester to quantify the bonding quality. With a contact pressure higher than 0.5 MPa, the TLB strength can reach a stable value of 10.5 MPa, which is comparable to those obtained by other popular bonding processes currently used by the packaging industry. The wafer surface conditions are evaluated by atomic force microscopy (AFM) and profilometry, while Auger electron spectroscopy (AES) and X-ray photoelectron spectroscopy (XPS) are used to study the characteristics of bonding interfaces. The AFM and profilometry results reveal that the wafer roughness and flatness required by TLB can be less stringent than those specified in the current industrial standards. The AES and XPS results are used to interpret the chemical and physical aspects of TLB formation and to provide the rationale for obtaining high-quality and high-strength TLB
RSV neutralization by palivizumab, but not by monoclonal antibodies targeting other epitopes, is augmented by Fc gamma receptors (2016)

Palivizumab efficiently blocks respiratory syncytial virus (RSV) infection in vitro. However, virus neutralization assays generally omit Fc region-mediated effects. We investigated the neutralization activity of RSV-specific monoclonal antibodies on cells with Fc receptors. Subneutralizing concentrations of antibodies resulted in antibody-dependent enhancement of RSV infection in monocytic cells. Contrary to antibodies targeting other epitopes, the neutralization by palivizumab was augmented in cells with Fc receptors. This unrecognized characteristic of palivizumab may be relevant for its performance in vivo.
Acceptor specificity of the human leukocyte  3 fucosyltransferase: role of FucT-VII in the generation of selectin ligands (1998)

The alpha3 fucosyltransferase, FucT-VII, is one of the key glycosyltransferases involved in the biosynthesis of the sialyl Lewis X (sLex) antigen on human leukocytes. The sialyl Lewis X antigen (NeuAcalpha(2-3)Galbeta(1-4)[Fucalpha(1-3)]GlcNAc-R) is an essential component of the recruitment of leukocytes to sites of inflammation, mediating the primary interaction between circulating leukocytes and activated endothelium. In order to characterize the enzymatic properties of the leukocyte alpha3 fucosyltransferase FucT-VII, the enzyme has been expressed in Trichoplusia ni insect cells. The enzyme is capable of synthesizing both sLexand sialyl-dimeric-Lexstructures in vitro , from 3'-sialyl-lacNAc and VIM-2 structures, respectively, with only low levels of fucose transfer observed to neutral or 3'-sulfated acceptors. Studies using fucosylated NeuAcalpha(2-3)-(Galbeta(1-4)GlcNAc)3-Me acceptors demonstrate that FucT-VII is able to synthesize both di-fucosylated and tri-fucosylated structures from mono-fucosylated precursors, but preferentially fucosylates the distal GlcNAc within a polylactosamine chain. Furthermore, the rate of fucosylation of the internal GlcNAc residues is reduced once fucose has been added to the distal GlcNAc. These results indicate that FucT-VII is capable of generating complex selectin ligands, in vitro , however the order of fucose addition to the lactosamine chain affects the rate of selectin ligand synthesis.
Design, Synthesis, and Pharmacological Evaluation of Conformationally Constrained Analogues of <i>N</i>,<i>N</i>‘-Diaryl- and <i>N</i>-Aryl-<i>N</i>-aralkylguanidines as Potent Inhibitors of Neuronal Na<sup>+</sup> Channels (1998)

In the present investigation, the rationale for the design, synthesis, and biological evaluation of potent inhibitors of neuronal Na+ channels is described. N,N'-diaryl- and N-aryl-N-aralkylguanidine templates were locked in conformations mimicking the permissible conformations of the flexible diarylguanidinium ion (AS+, AA+, SS+). The resulting set of constrained guanidines termed "lockamers" (cyclophane, quinazoline, aminopyrimidazolines, aminoimidazolines, azocino- and tetrahydroquinolinocarboximidamides) was examined for neuronal Na+ channel blockade properties. Inhibition of [14C]guanidinium ion influx in CHO cells expressing type IIA Na+ channels showed that the aminopyrimidazoline 9b and aminoimidazoline 9d, compounds proposed to lock the N,N'-diarylguanidinium in an SS+ conformation, were the most potent Na+ channel blockers with IC50's of 0.06 microM, a value 17 times lower than that of the parent flexible compound 18d. The rest of the restricted analogues with 4-p-alkyl substituents retained potency with IC50 values ranging between 0.46 and 2.9 microM. Evaluation in a synaptosomal 45Ca2+ influx assay showed that 9b did not exhibit high selectivity for neuronal Na+ vs Ca2+ channels. The retention of significant neuronal Na+ blockade in all types of semirigid conformers gives evidence for a multiple mode of binding in this class of compounds and can possibly be attributed to a poor structural specificity of the site(s) of action. Compound 9b was also found to be the most active compound in vivo based on the high level of inhibition of seizures exhibited in the DBA/2 mouse model. The pKa value of 9b indicates that 9b binds to the channel in its protonated form, and log D vs pH measurements suggest that ion-pair partitioning contributes to membrane transport. This compound stands out as an interesting lead for further development of neurotherapeutic agents.
Investigating the roots of the favourite–longshot bias: an analysis of decision making by supply‐ and demand‐side agents in parallel betting markets (2000)

This paper offers new insights into the behavioural origins of the ‘favourite–longshot’ bias — an established feature of betting markets, whereby longshots win less often than the subjective probabilities imply and favourites more often. A number of alternative explanations has been offered for this phenomenon but the main debate focuses on whether it is caused by the behaviour of those supplying betting markets (bookmakers) or of the demand-side agents in these markets (bettors) . This study analyses a new data source which offers detailed information for a large sample of recent UK horseraces on decision-making behaviour within the parimutuel and the parallel bookmaker-based betting markets. The results offer strong evidence for the existence of the ‘favourite–longshot’ bias in bookmaker-based markets, with a corresponding absence of such an effect in the parimutuel case. These results offer support for the view that the origins of the ‘favourite–longshot’ bias lie principally in the decisions of bookmakers rather than in the decisions of bettors. Copyright © 2000 John Wiley & Sons, Ltd.
Ferric ion sequestering agents. 1. Hexadentate O-bonding N,N',N"-tris(2,3-dihydroxybenzoyl) derivatives of 1,5,9-triazacyclotridecane and 1,3,5-triaminomethylbenzene (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFerric ion sequestering agents. 1. Hexadentate O-bonding N,N',N"-tris(2,3-dihydroxybenzoyl) derivatives of 1,5,9-triazacyclotridecane and 1,3,5-triaminomethylbenzeneFrederick L. Weitl and Kenneth N. RaymondCite this: J. Am. Chem. Soc. 1979, 101, 10, 2728–2731Publication Date (Print):May 1, 1979Publication History Published online1 May 2002Published inissue 1 May 1979https://pubs.acs.org/doi/10.1021/ja00504a039https://doi.org/10.1021/ja00504a039research-articleACS PublicationsRequest reuse permissionsArticle Views871Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oxidative Decarboxylation of Levulinic Acid by Cupric Oxides (2010)

In this paper, cupric oxides was found to effectively oxidize levulinic acid (LA) and lead to the decarboxylation of levulinic acid to 2-butanone. The effects of cupric oxide dosage, reaction time and initial pH value were investigated in batch experiments and a plausible mechanism was proposed. The results showed that LA decarboxylation over cupric oxides at around 300 °C under acidic conditions produced the highest yield of butanone (67.5%). In order to elucidate the catalytic activity of cupric oxides, XRD, AFM, XPS and H(2)-TPR techniques was applied to examine their molecular surfaces and their effects on the reaction process.
Protection against acetaminophen‐induced hepatotoxicity by L‐CySSME and its N‐acetyl and ethyl ester derivatives (1996)

We have recently observed that S-(2-hydroxyethylmercapto)-L-cysteine (L-CySSME), the mixed disulfide of L-cysteine and 2-mercaptoethanol, prevented cataracts induced in mice by acetaminophen (ACP) by functioning as a prodrug of L-cysteine and protecting the liver. This prompted the evaluation of the more lipophilic N-acetyl (Ac-CySSME) and ethyl ester (Et-CySSME) derivatives of L-CySSME as pro-prodrug forms, as well as the “D” enantiomer, as hepatoprotective agents. Serum ALT levels were measured at 24 hours after a toxic but nonlethal dose of ACP that insured 48 hour survival of the animals. Since the increases in ALT produced were highly variable (even after log transformation) and complicated the statistical analyses, we calculated confidence intervals for the mean ALT levels for each treatment group. This enabled comparisons to be made of the efficacy of L-CySSME as well as Ac-CySSME and Et-CySSME with other representative prodrugs of L-cysteine, namely, 2(RS)-methylthiazolidine-4(R)-carboxylic acid (MTCA), L-2-oxothiazolidine-4-carboxylic acid (OTCA), and N-acetyl-L-cysteine (NAC), in protecting the liver. It was shown that L-CySSME and MTCA administered intraperitoneally at 2.5 mmol/kg were superior to the other cysteine prodrugs at equimolar doses in protecting mice from hepatotoxicity elicited by a 400 mg/kg (2.65 mmol/kg) dose of ACP given i.p. 30 minutes prior to the prodrugs. The “D” form of CySSME was totally without protective effect. Oral doses of the prodrugs even at 2× the i.p. dose were less effective, although MTCA was the most protective. © 1997 John Wiley & Sons, Inc. J Biochem Toxicol 11: 289–295, 1997.