gebhart/patrepeval huggingface dataset:
Performance evaluation of RESTful web services and AMQP protocol (2013)

Web services appeared as a promising technology for Web environments independent of technologies, services, and applications. Currently, there are some issues related with this approach that should be studied. For instance, if massive quantities of data are sent to databases it can influence significantly the performance of the whole system. The Advanced Message Queuing Protocol (AMPQ) appears as a promising solution to address this problem. Then, in order to evaluate the performance of this approach, this paper presents a performance comparison study of RESTful Web services and the AMQP Protocol considering exchanging messages between client and server. The study is based on the averaged exchanged messages for a period of time. It was observed and concluded that, for large quantities of messages exchange, the best results comes from the Advanced Message Queuing Protocol.
Supply chain simulation: distributed supply chain simulation using a generic job running framework (2003)

For supply chain performance simulation that involves aggregating results from multiple runs of the same underlying model, simulation iterations can be distributed to networked computing resources to achieve significant speedup. This paper presents a generic distributed job running framework that facilitates such high performance supply chain simulation. We first introduce a supply chain modeling and simulation tool developed by IBM Research, and summarize the strategy to enhance it. A closer look is then taken at a generic job running framework we designed and how it was used to bring the distributed simulation capability to the tool. After reviewing an ongoing effort to integrate the new tool with the IBM MathGrid environment, we conclude the paper with a brief discussion of our future work.
Explaining the Gibbs Sampler (1992)

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Simple One-Week Method to Construct Gene-Targeting Vectors: Application to Production of Human Knockout Cell Lines (2006)

Targeted gene disruption is a powerful tool for studying gene function in cells and animals. In addition, this technology includes a potential to correct disease-causing mutations. However, constructing targeting vectors is a laborious step in the gene-targeting strategy, even apart from the low efficiency of homologous recombination in mammals. Here, we introduce a quick and simplified method to construct targeting vectors. This method is based on the commercially available MultiSite Gateway technology. The sole critical step is to design primers to PCR amplify genomic fragments for homologous DNA arms, after which neither ligation reaction nor extensive restriction mapping is necessary at all. The method therefore is readily applicable to embryonic stem (ES) cell studies as well as all organisms whose genome has been sequenced. Recently, we and others have shown that the human pre-B cell line Nalm-6 allows for high-efficiency gene targeting. The combination of the simplified vector construction system and the high-efficiency gene targeting in the Nalm-6 cell line has enabled rapid disruption of virtually any locus of the human genome within one month, and homozygous knockout clones lacking a human gene of interest can be created within 2-3 months. Thus, our system greatly facilitates reverse genetic studies of mammalian--particularly human--genes.
Prophylaxis of Bipolar Affective Disorders (1990)

AbstractWhile lithium carbonate remains the treatment of choice for bipolar affective disorders, there is increasing recognition that a substantial proportion of patients do not show a complete response. Although unimodal antidepressants and neuroleptics were used almost exclusively a decade ago for respective breakthrough episodes of depression and mania occurring during lithium prophylaxis, a new series of treatment alternatives, particularly the anticonvulsants, has become available. Increasing evidence suggests that carbamazepine, when used either adjunctively or, in some instances, alone, may provide adequate prophylaxis for the lithium non-responder. Preliminary evidence indicates that some variables that are highly associated with lithium non-response (such as rapid cycling) may be associated with a good response to carbamazepine or valproate. Response to one anticonvulsant agent does not appear to predict response to another, and we have observed some patients who responded to carbamazepine and not valproate, and vice versa. There are relatively few data on clinical and biological markers of response to lithium compared with the anticonvulsants, and virtually no data indicating responsivity among the anticonvulsants or marking those patients who require combination therapy. Preliminary data suggest that novel strategies such as thyroid potentiation with suppressive doses or use of calcium channel blockers may also be of clinical utility in the treatment of the refractory bipolar patient.The author emphasizes the recurrent and, at times, malignantly progressive nature of manic-depressive illness and the need for early recognition and prophylaxis in the hope of halting this progression. Two preclinical models, those of behavioral sensitization to psychomotor stimulants and electrophysiological kindling, are presented for their heuristic value in assessing possible principles underlying the progressive evolution of psychopathological and neuropathological syndromes. These data further suggest the importance of early intervention as well as the possibility that pharmacotherapeutic responsiveness may vary as a function of when in the stage of evolution of an illness one intervenes. A series of possible explanations for loss of efficacy to drugs that were initially effective in the treatment of manic-depressive illness is also discussed.
Geodesic Math and How to Use It (2005)

It was 1976—twenty-five years after R. Buckminster Fuller introduced geodesic domes when literary critic Hugh Kenner published this fully-illustrated practical manual for their construction. Now, some twenty-five years later, Geodesic Math and How to Use It again presents a systematic method of design and provides a step-by-step method for producing mathematical specifications for orthodox geodesic domes, as well as for a variety of elliptical, super-elliptical, and other nonspherical contours. Out of print since 1990, Geodesic Math and How To Use It is California's most requested backlist title. This edition is fully illustrated with complete original appendices.
Precision Modeling and Optimally-safe Design of Quadcopters for Controlled Crash Landing in Case of Rotor Failure (2019)

The seminal work cited in [1],[2] showed, for the first time, that flight stability of quadcopters would be possible in case of one or even multiple rotor failures. However, the quadcopter can remain airborne only by going through a spinning maneuver about an axis, fixed w.r.t the vehicle (i.e., resolved yaw). Furthermore, positional control can be achieved by periodically tilting this axis. This paper builds upon this concept with two major improvements: (1) introducing a precise aerodynamic model of propellers that takes the flapping torque due to unbalanced lifting force in the advancing and retreating blades subjected to freestream, into account, and (2) adding to the stability and flight efficiency of the quadcopter by introducing symmetric fixed tilting angles to the trust vectors. In our previous work [3], it was shown how the flight stability and energy efficiency can be improved by introducing fixed tilting angles in the thrust vectors. For controlled crash landing in case of one rotor failure, where a resolved yaw maneuver would be inevitable, introducing a titling angle in rotors can generate a reasonable resolved-rate-yaw spinning speed to keep the quadcopter airborne at a lower rotational speed of the blades by taking advantage of the freestream generated by spinning. This tilting angle would also lead to passive stability in yaw motion of the quadcopter before the failure. Our hypothesis was successfully tested via simulations.
One-shot dual-energy subtraction imaging. (1986)

Dual-energy subtraction imaging by a single x-ray exposure (one shot) can easily be performed by using computed radiography with scanning laser-stimulated luminescence. In a phantom study, a thin copper filter placed between two imaging plates produced a dual-energy subtracted image from a single x-ray exposure. One-shot dual-energy subtraction imaging was also useful in the diagnosis of thoracic lesions.
Cross-Resistance to <i>Bacillus thuringiensis</i> Toxin CryIF in the Diamondback Moth ( <i>Plutella xylostella</i> ) (1994)

Selection with Bacillus thuringiensis subsp. kurstaki, which contains CryIA and CryII toxins, caused a >200-fold cross-resistance to CryIF toxin from B. thuringiensis subsp. aizawai in the diamondback moth, Plutella xylostella. CryIE was not toxic, but CryIB was highly toxic to both selected and unselected larvae. The results show that extremely high levels of cross-resistance can be conferred across classes of CryI toxins of B. thuringiensis.
NSCL-2: a basic domain helix-loop-helix gene expressed in early neurogenesis. (1992)

We have identified a new basic domain helix-loop-helix (bHLH) gene, NSCL-2, which was cloned because of its homology to the previously described putative hematopoietic transcription factor, SCL. NSCL-2 has been identified in both human and murine DNA. NSCL-2 complementary DNA clones were obtained from an 11.5-day murine embryo library. The coding region is 405 base pairs and encodes a predicted protein of 15.6 kilodaltons. There is 74% homology at the nucleotide level with the coding region of the murine SCL and 27% protein homology. Unlike the majority of previously described bHLH genes, the NSCL-2 coding region ends only six amino acids beyond the second amphipathic helix of the HLH domain. The NSCL-2 gene shows a markedly restricted pattern of expression predominantly confined to murine embryos at days 11-13 of development, although low level expression can be detected in murine embryos flanking this time point. Examination of 11- and 12-day mouse embryos by tissue in situ hybridization reveals expression of NSCL-2 in the developing nervous system, most likely in developing neurons. The NSCL-2 gene maps to murine chromosome 3. The temporally and tissue restricted pattern of expression of this gene and its identification as a member of a family of transcription factors relevant to growth and development in a wide variety of species suggest a role for NSCL-2 in the development of the eukaryotic nervous system.
Independent and core pathways in oncogenic KRAS signaling (2016)

KEYWORDS: KRASK-Ras4Blung cancerpancreatic cancerRas pathwayscell cycleRas effectorsPI3KRafRas isoforms
Gene‐dosage dependent overexpression at the 13q amplicon identifies <i>DIS3</i> as candidate oncogene in colorectal cancer progression (2014)

Colorectal cancer (CRC) development is in most cases marked by the accumulation of genomic alterations including gain of the entire q-arm of chromosome 13. This aberration occurs in 40%-60% of all CRC and is associated with progression from adenoma to carcinoma. To date, little is known about the effect of the 13q amplicon on the expression of the therein located genes and their functional relevance. We therefore aimed to identify candidate genes at the 13q amplicon that contribute to colorectal adenoma to carcinoma progression in a gene dosage-dependent manner. Integrative analysis of whole genome expression and DNA copy number signatures resulted in the identification of 36 genes on 13q of which significant overexpression in carcinomas compared with adenomas was linked to a copy number gain. Five genes showing high levels of overexpression in carcinomas versus adenomas were further tested by quantitative reverse transcription-PCR in two independent sample sets of colorectal tumors (n = 40 and n = 47). DIS3 and LRCH1 revealed significant overexpression in carcinomas compared with adenomas in a 13q gain dependent manner. Silencing of DIS3 affected important tumorigenic characteristics such as viability, migration, and invasion. In conclusion, significant overexpression of DIS3 and LRCH1 associated with adenoma to carcinoma progression is linked to the CRC specific gain of 13q. The functional relevance of this copy number aberration was corroborated for DIS3, thereby identifying this gene as novel candidate oncogene contributing to the 13q-driven adenoma to carcinoma progression.
Serological analysis of herpes simplex virus types 1 and 2 with monoclonal antibodies (1982)

A panel of monoclonal antibodies to herpes simplex virus glycoproteins was used for serological analysis of 130 strains. Based on specific immunological determinants, strains of each serotype clustered into subgroups. Monoclonal antibodies were suitable reagents for serotyping and have potential application to epidemiology of herpes simplex virus infections.
Tumbling atoms and evidence for charge transfer in La2@C80@SWNT (2000)

Using transmission electron microscopy, we demonstrate the insertion of the metallofullerene La2@C80 into 1.4 nm diameter single wall carbon nanotubes. Micrographs indicate that the spheroidal D2h isomer having an IhC80 cage ∼0.8 nm in diameter is preferred. For the first time, endohedral atoms inside a metallofullerene are directly imaged. The La atoms are seen to undergo a discontinuous tumbling motion inside their C80 cage. The measured La–La separation is slightly larger than is predicted by theory. These data suggest that interactions between the nanotube and La2@C80 have changed the molecules' behaviors. Our results prove that extrinsic molecular species can be introduced into carbon nanotubes.
Role of p53 in Cell Death and Human Cancers (2011)

p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of the classical type tumor suppressors. Mutant p53 acts as the dominant-negative inhibitor toward wild-type p53. Indeed, mutant p53 has an oncogenic potential. In some cases, malignant cancer cells bearing p53 mutations display a chemo-resistant phenotype. In response to a variety of cellular stresses such as DNA damage, p53 is induced to accumulate in cell nucleus to exert its pro-apoptotic function. Activated p53 promotes cell cycle arrest to allow DNA repair and/or apoptosis to prevent the propagation of cells with serious DNA damage through the transactivation of its target genes implicated in the induction of cell cycle arrest and/or apoptosis. Thus, the DNA-binding activity of p53 is tightly linked to its tumor suppressive function. In the present review article, we describe the regulatory mechanisms of p53 and also p53-mediated therapeutic strategies to cure malignant cancers.
Optimization strategies for additional actuators of kinematically redundant parallel kinematic machines (2010)

In this paper five different optimization strategies for kinematically redundant mechanisms, i.e. mechanisms having additional actuator(s) in at least one kinematic chain, are presented. They are based on two main approaches, a discrete optimization and a classical continuous optimization. Exemplarily, a planar, kinematically redundant 3RRR-based mechanism is introduced. The position of its redundant actuator, i.e. the robot geometry, is optimized according to an optimization criterion that is denoted as the gain of the maximal homogenized pose error. Several analysis examples demonstrate the effectiveness of kinematic redundancy with respect to the introduced optimization procedures. It is shown that in comparison to discrete approaches, classical continuousbased optimization strategies do not necessarily lead to more appropriate results in terms of performance improvement.
Generation of somatic cell hybrids for the production of biologically active factors that stimulate proliferation of other cells (2007)

Our results question the validity of cellular senescence as a dominant trait. Additionally, the generation of hybrid cells using the specific mouse cell line can be applied to the generation of hybrids with other normal cell types and can be used to produce tissue-specific growth-factor(s) to extend the lifespan and/or improve the proliferation of various normal cells, including adult stem cells.
Certificazione delle competenze e strategie didattiche. Opportunità formative per l’equità sociale (2007)

Nella attuale società post-industriale il possesso di competenze sta diventando un forte fattore di discriminazione di fronte alla disoccupazione, agli sconvolgimenti tecnici, alle disuguaglianze in termini di reddito e di qualità della vita. Nella prospettiva di un apprendimento non più confinato agli anni della scolarizzazione ma esteso a tutta la vita, la questione della costruzione di competenze e della loro certificazione, a partire dal sistema scolastico, può rappresentare l’insieme dei nodi attorno ai quali giocare il rinnovamento del sistema formativo. Il volume affronta questa complessa problematica da una duplice prospettiva. La prima muove dalla constatazione che esiste una particolarissima triangolazione “dinamica” tra i tre concetti chiave del discorso, certificazione, crediti e competenze, e dall’idea che la definizione di questa relazione possa determinare il futuro stesso della scuola del terzo millennio e la qualità dell’offerta formativa. La seconda, invece, dal considerare il principio di uguaglianza, nelle sue diverse declinazioni, come il paradigma che, se posto alla base di ogni riflessione teorica e di ogni scelta organizzativa e didattica concreta, è in grado di caratterizzare i processi formativi essenzialmente come contributi all’equità dell’intero sistema sociale e allo sviluppo della democrazia. A partire dunque da una ricognizione delle questioni poste dal problema della certificazione, il volume cerca di mostrare come una base culturale ampia e solida, una didattica moderna, flessibile ed efficace ed un sistema certificatorio condiviso, riferito a precisi standard di qualità, contribuendo ad impedire che vengano perpetuate situazioni di privilegio sociale ed economico, possano costituire alcune delle leve del cambiamento sociale.
Targeting Subchondral Bone Mesenchymal Stem Cell Activities for Intrinsic Joint Repair in Osteoarthritis (2017)

Osteoarthritis (OA) is a common age-related disease with complex pathophysiology. It is characterized by wide-ranging tissue damage and ultimate biomechanical failure of the whole joint. However, signs of tissue adaptation and attempted repair responses are evident in OA-affected osteochondral tissues. Highlighted in this review article is the role of bone-resident mesenchymal stem cells (MSCs) in these bone remodeling responses, and a proposal that targeting MSC activities in OA subchondral bone could represent a novel approach for intrinsic joint regeneration in OA. The development of these therapies will require better understanding of MSC proliferation, migration and differentiation patterns in relation to OA tissue damage and further clarification of the molecular signaling events in these MSCs during disease progression.
Investigation of optical loss mechanisms in oxide thin films (1995)

Abstract KNbO3, K(Ta,Nb)O3, KTaO3, and Ta2O5 thin films have been grown by ion-beam sputter deposition. KNbO3 has excellent nonlinear properties for second harmonic generation; however, high optical losses are still characteristic of these films. Several loss mechanisms, such as, high angle grain boundaries, twin domains, interface and surface scattering, and oxygen vacancies can all contribute to the high losses. In order to isolate the various mechanisms, amorphous Ta2O5 films, epitaxial cubic KTaO3 and tetragonal K(Ta,Nb)O3 films were grown on MgO and Al2O3 substrates subjected to post-deposition annealing treatments and various oxygen pressure conditions. The optical losses and refractive indices were observed to differ depending on the substrate surface and annealing treatments. Resonant scattering experiments were performed to analyze the oxygen composition. The optical properties of these oxide thin film systems are reported and the breakdown of the loss mechanisms is addressed.
Contraception: Science and Practice (1989)

Birth control - a world view, M.Potts and P.Bhiwandiwala metabolic effects of combined oral contraceptives, M.D.G.Gillmer complications of combined oral contraception, J.Drife oral contraception and cancer, M.P.Vessey practical prescribing of the combined oral contraceptive pill, J.Guillebaud the progestogen-only pill, K.Fotherby systemic hormonal contraception by non-oral routes, I.S.Fraser postcoital contraception, A.Yuzpe and A.Kubba intrauterine contraceptive devices, H.JTatum and kE.B.Connell male and female barrier contraceptive methods, Walli Bounds natural family planning, Anna M.Flynn and J.Bonnar contraception for the older woman, P.Bowen-Simpkins cervical ripening prior to termination of pregnancy, G.M.Filshie et al abortion, G.M.Filshie female sterilization and it reversal, J.E.Rioux vasectomy and vasectomy reversal, W.F.Hendry progress towards a systematic male contraceptive, S.L.Jeffcoate.
Effects of CO2 on Total Phenolics, Phenylalanine Ammonia Lyase, and Polyphenol Oxidase in Lettuce Tissue (1985)

Abstract An atmosphere of air + 15% CO 2 caused CO 2 injury in lettuce ( Lactuca sativa L.) in about 10 days at 0°C. However, subsequent removal of CO 2 was necessary for the brown stain symptoms to develop. Under CO 2 treatment, phenylalanine ammonia lyase (PAL) was induced and its activity correlated well with the development of the injury. Nevertheless, PAL activity did not seem responsible for the differences in susceptibility to CO 2 injury among the 3 lettuce cultivars included in this study. Prevention of the development of brown stain symptoms by CO 2 probably was due to its inhibition of phenolics production and the inhibition of polyphenol oxidase activity.
An Implementation of Wireless Sensor Network in Monitoring of Parkinson's Patients Using Received Signal Strength Indicator (2013)

Remote monitoring of patients with movement disorders is currently being researched extensively with the help of Wireless Body Area Sensor Network (WBASN). e-Healthcare is one such popular WBASN application. We focus our research addressing an important issue of wireless monitoring of patients suffering from Parkinson's Disease (PD) for fall detection in order to avoid potential injuries. We also propose a non-invasive, wireless technique that could detect multiple occurrences of Freezing of Gait (FoG) over single or multiple days of observation. For wireless monitoring of patients, we would embed wireless sensors in patient's vicinity, such as his room and determine the values of Received Signal Strength Indicator (RSSI) from these sensors. RSSI can thus be used as one of the measures to detect falls of PD patients. Our initial results of embedding force sensors in person's shoe, suggest that it can be used to detect and record the number of occurrences of FoG, which is hard to reproduce at doctor's clinic, due to its relation with patient's consciousness at the hospital. We also propose to derive different mobility patterns for a PD patient based on the RSSI values during a day's activity and then train the system for intelligent analysis in future.