gebhart/patrepeval huggingface dataset:
INHIBITORY EFFECT OF HEPARIN ON HERPES SIMPLEX VIRUS (1964)

Nahmias, André J. (Boston University School of Medicine, Boston, Mass.), and Sidney Kibrick. Inhibitory effect of heparin on herpes simplex virus. J. Bacteriol. 87:1060-1066. 1964.-A substance inhibitory to herpes simplex virus was observed during experiments with leukocyte cultures. The component in the cultures responsible for this inhibition was identified as heparin. The minimal inhibitory concentration required to inhibit 30 to 300 tcd(50) of the virus in human amnion tissue culture was found to be 1 to 2 units per ml (10 to 20 mug/ml). This effect was confirmed with other strains of herpes simplex virus, other tissue-culture systems, and other media. The inhibitory activity of the heparin was found to be related to the sulfate groupings on the molecule. The effect of heparin appears to be on the virus, rather than on the cell. The virus is not inactivated, however, and the heparin-virus "complex" is readily dissociable on dilution. Heparin was shown to affect viral infection in its earliest phase, probably at the primary electrostatic attachment of virus to cell. The import of these and related observations on common virological laboratory procedures and the possible biological significance of our findings are discussed.
Extrauterine Mesodermal (Müllerian) Adenosarcoma: A Clinicopathologic Analysis of Five Cases (1978)

Five extrauterine examples (three pelvic and two ovarian) of a distinctive mesodermal (müllerian) mixed tumor previously described to occur in the uterus and designated müllerian adenosarcoma are reported. The tumors were diagnosed during the fifth to eight decades of life. They usually formed very large, partly cystic masses, which had occasionally spread to adjacent organs by the time of operation. On microscopic examination the tumors consisted of benign-appearing neoplastic glands lying in a sarcomatous stroma. The glands were lined by a variety of müllerian epithelial cell types, and the stromal element resembled endometrial stromal sarcoma. Three patients had malignant courses manifested by intrabdominal recurrence, distant metastases, or both. This tumor should be clearly distinguished from the more common forms of mesodermal (müllerian) mixed tumor in which the epithilial as well as the stromal component is malignant and the prognosis is much more grave.
The Influence of Phosphatidylserine Supplementation on Mood and Heart Rate when Faced with an Acute Stressor (2001)

There have been previous reports that supplements of phosphatidylserine (PS) blunted the release of cortisol in response to exercise stress and that it improved mood. The present study extended these observations by considering whether PS supplementation influenced subjective feelings of stress and the change in heart rate when a stressful mental arithmetic task was performed. In young adults, with neuroticism scores above rather than below the median, the taking of 300mg PS each day for a month was associated with feeling less stressed and having a better mood. The study for the first time reports an improvement in mood following PS supplementation in a sub-group of young healthy adults.
Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts (2016)

Our results demonstrate that cfDNA reflects persisting EpCAM-positive CTCs in patients with high CTC counts and therefore may enable monitoring of the metastatic burden for clinical decision-making. Clin Cancer Res; 23(1); 88-96. ©2016 AACR.
Linear Starch Reagents. Cadmium Iodide-Linear Starch Reagent (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLinear Starch Reagents. Cadmium Iodide-Linear Starch ReagentJ. L. LambertCite this: Anal. Chem. 1951, 23, 9, 1247–1251Publication Date (Print):September 1, 1951Publication History Published online1 May 2002Published inissue 1 September 1951https://pubs.acs.org/doi/10.1021/ac60057a011https://doi.org/10.1021/ac60057a011research-articleACS PublicationsRequest reuse permissionsArticle Views209Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of vaccines designed to induce protective cellular immunity against the Plasmodium yoelii circumsporozoite protein: vaccinia, pseudorabies, and Salmonella transformed with circumsporozoite gene. (1990)

In an attempt to induce a protective cytotoxic T-cell mediated immunity against sporozoites of Plasmodium yoelii, the gene encoding the P. yoelii circumsporozoite (CS) protein was engineered into three live vectors: vaccinia, attenuated pseudorabies, and attenuated Salmonella typhimurium. Balb/c mice were immunized with 1-4 doses of 10(8) pfu of the vaccinia construct (IP), 3 doses of 10(5), 10(6) or 10(7) pfu of pseudorabies construct (IV), and 3 doses of 10(9) salmonella transformants (orally). In the case of vaccinia and pseudorabies constructs, an excellent immune response was obtained as measured by antibodies to sporozoites. No protection or delay in prepatent period was seen in any of the experimental animals when challenged with 200 (vaccinia, pseudorabies) or 100 (salmonella) sporozoites, although mice immunized with irradiation-attenuated sporozoites were consistently protected against challenge with greater than 10(4) sporozoites. Since other vaccinia, pseudorabies, and salmonella CS constructs have been shown to induce cytotoxic T lymphocytes (CTL) against the CS protein, it is likely that CTL against the CS protein were induced during these studies. It is currently unclear if the vaccines did not induce the appropriate CTL or inadequate numbers of CTL, or if CTL against the P. yoelii CS protein are inadequate to protect against sporozoite challenge.
Voltage Scaled STT-MRAMs Towards Minimum-Energy Write Access (2016)

This paper investigates the impact of voltage scaling on energy and performance of STT-MRAM arrays under write access, which is well known to be energy critical. Simple analytical models of energy and delay are introduced to gain an insight into the energy-performance tradeoff at low voltages, and minimum-energy operation. The minimum-energy point is found to lie at voltages that are substantially higher than CMOS logic and memories. The impact of voltage scaling on the area-energy-performance tradeoff on most representative STT-MRAM bitcells is investigated and justified through the proposed models. Interestingly, bitcell area optimization is shown to enable 25%-40% energy savings compared to minimum-sized bitcells, when operating at low voltages. Results show that the write energy reduction achieved through voltage scaling strongly depends on the adopted bitcell, and was found to be up to 20%-30% in a 65-nm and 28-nm array. Voltage scaling is expected to become mainstream in STT-MRAM design, as promising approach to mitigate the well-known issue of large write energy consumption.
Reversible recording of holograms in glassy chalcogenide semiconductors at elevated temperatures (1976)

An investigation was made of the influence of temperature on the optical properties of plane-parallel plates (0.2–0.8 mm thick) of glassy arsenic sulfide. At elevated temperatures, close to the glass-transition temperature (180°C), the hologram-recording properties of this material improved considerably: the parameters were found to be stable in reversible recording, the maximum possible diffraction efficiency increased to ~50%, and the sensitivity of the plates to the radiation became greater (the hologram recording time fell to several seconds). It was found possible to record information in real time and to read holograms nondestructively in As2S3 plates with the same He–Ne laser beam (632.8 nm).
Stereoselective Preparation of Dienol Phosphates from α,β-Ethylenic Aldehydes (2008)

The first stereoselective method of preparation of (E)-dienol phosphates from alpha,beta-ethylenic aldehydes is described. The key point is the stereoselective enolization of conjugated alkenals by potassium tert-butoxide in the presence of N-methylpyrrolidinone (NMP).
Synthesis, Structure, and Olefin Polymerization Activity of Vanadium(V) Catalysts Stabilized by Imido and Hydrotris(pyrazolyl)borato Ligands (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, Structure, and Olefin Polymerization Activity of Vanadium(V) Catalysts Stabilized by Imido and Hydrotris(pyrazolyl)borato LigandsSylvie Scheuer, Jean Fischer, and Jacky KressCite this: Organometallics 1995, 14, 6, 2627–2629Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/om00006a006https://doi.org/10.1021/om00006a006research-articleACS PublicationsRequest reuse permissionsArticle Views301Altmetric-Citations113LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Insights into cross- and within-store price search: retailer estimates vs. consumer self-reports (2000)

Past research of the accuracy of retail grocers’ beliefs about consumer search and patronage behavior has found that executives tend to overestimate the size of the consumer segment that regularly switches stores for price specials. With surveys of consumers and executives in a large midwestern market, we extend and replicate the earlier research. In this study, we find that executives demonstrate, on average, an accurate sense of the proportion of consumers who are primarily loyal to one store or are shoppers of multiple stores. However, they still tend to overestimate aggregate price comparison behavior and cross-store shopping. At the same time, we also find that managers simultaneously underestimate consumer newspaper readership, in-store search for specials, and stockpiling. This new result suggests that the more loyal primary customers may account for a greater proportion of incremental promotional sales than has been recognized in the past. These results suggest a significant increase in the information value to be derived from the desegregation of sales data by shopper loyalty status.
Influence of A-T content on the fractionation of DNA restriction fragments by RPC-5 column chromatography. (1979)

The properties of the fractionated Hae III fragments of pRZ2 DNA (Patient, R.K., Hardies, S.C., and Wells, R.D. (1979) J. Biol. Chem. 254, 5542-5547) were studied in an effort to determine why several of the fragments bind more tightly to RPC-5 than expected on the basis of their length. The purified fragments were analyzed for their nucleotide composition by direct determination of their constituent mononucleotides and by analytical CsCl and Cs2SO4 density gradient analyses. A-T-rich fragments elute at higher salt concentrations than fragments of equivalent size which are not A-T-rich. In addition, denaturation mapping studies by electron microscopy indicate that an A-T-rich run within an otherwise G-C-rich fragment can give rise to delayed elution. At least one other factor influences the separation of DNA restriction fragments by RPC-5 chromatography. Some of the fragments in this digest which elute later than predicted from their size either contain known genetic regulatory sites or bind regulatory proteins.
Isolating relevant component interactions with JINSI (2006)

When a component in a large system fails, developers encounter two problems: (1) reproducing the failure, and (2) investigating the causes of such a failure. Our JINSI tool lets developers capture and replay the interactions between a component and its environment, thus allowing for reproducing the failure at will. In addition, JINSI uses delta debugging to automatically isolate the subset of the interactions that is relevant for the failure. In a first study, JINSI has successfully isolated the relevant interaction of a JAVA component: "Out of the 32 interactions with the <VendingMachine> (BOB - wasn't sure about this one)component, seven interactions suffice to produce the failure.
In vivo hematologic effects of recombinant human macrophage colony- stimulating factor (1990)

Macrophage colony-stimulating factor (recombinant human M-CSF) given as a single intravenous injection to Lewis rats induces a dose-dependent peripheral monocytosis, neutrophilia, and lymphopenia. The monocytosis peaks at 28 to 32 hours with a seven- to eightfold increase in the number of circulating monocytes and promonocytes. The peripheral monocytosis is accompanied by a slight increase in marrow blasts, promonocytes, and monocytes. A monocytopenia reaching a nadir at 15 minutes precedes the monocytosis, suggesting that M-CSF activates circulating monocytes and causes intravascular margination. The M-CSF-induced neutrophilia and lymphopenia are relatively mild in magnitude, are observed between 2 and 16 hours after injection, and are no longer evident at later time-points. The monocytosis was at least partially inhibited by dexamethasone. M-CSF-induced monocytosis most likely reflects a direct effect of M-CSF on marrow monocyte precursor proliferation, maturation, and release, whereas the neutrophilia and lymphopenia may reflect indirect effects mediated by the known ability of M-CSF to cause the release of other cytokines.
Seebeck Effect of Fe-Al-Si Alloy and Low Temperature Thermoelectric Properties (1998)

The thermoelectric conversion offers unique possibility of a gigantic electric power generation utilizing low-temperature heat sources below 600K. Such sources are solar heat, terrestrial heat and exhaust waste heat from the central-station steam-electric plant. They are thermodynamically low grade but infinite and gratis. The immense production of electricity by this principle is made possible exclusively by means of the thermoelectric junction between the iron-based alloys as the conversion materials because these components of the generator can be manufactured on an efficient mass production basis. Among several possible thermoelectric junctions basically consisted of iron, the Fe13%Al12%Si (p) -Fe12%Al (n) alloy couple has been found to exhibit a relatively high value of thermoelectric power, 71μV/K. The merit of this thermoelectric power junction with respect to the thermoelectric conversion has also been described by measuring other thermoelectric properties of these elements.
A comprehensive study of Convergent and Commutative Replicated Data Types (2011)

Eventual consistency aims to ensure that replicas of some mutable shared object converge without foreground synchronisation. Previous approaches to eventual consistency are ad-hoc and error-prone. We study a principled approach: to base the design of shared data types on some simple formal conditions that are sufficient to guarantee eventual consistency. We call these types Convergent or Commutative Replicated Data Types (CRDTs). This paper formalises asynchronous object replication, either state based or operation based, and provides a sufficient condition appropriate for each case. It describes several useful CRDTs, including container data types supporting both \add and \remove operations with clean semantics, and more complex types such as graphs, montonic DAGs, and sequences. It discusses some properties needed to implement non-trivial CRDTs.
The use of recombinant activated Factor VII in the control of haemorrhage following blunt pelvic trauma (2005)

This article reports two cases of severe blunt pelvic trauma associated with road traffic accidents, where the patients developed significant bleeding and haemodynamic instability, poorly responsive to conventional management. Both patients required massive transfusion of blood products with a resultant dilutional coagulopathy. In each case, a single dose of recombinant activated factor VII (rFVIIa) was used to achieve haemostatic control, with a subsequent decrease in blood product requirements and improvement in haemoglobin concentration and clotting profile.
Optimal Unemployment Insurance: A Survey (1999)

Unemployment insurance improves the allocation of risk bearing at the cost of reduced incentives for work. In the past two decades, a branch of the literature has emerged that deals with the optimal design of unemployment insurance. This literature has been influenced by ideas and methods from information economics and by theories from labor economics. The result is a collection of models designed to highlight a variety of issues pertaining to the provision of optimal unemployment insurance. This paper reviews these issues, summarizes the relevant literature, assesses its accomplishments, and points out problems that require further study.
Mapping neural dynamics underlying saccade preparation and execution and their relation to reaction time and direction errors (2020)

Our ability to control and inhibit automatic behaviors is crucial for negotiating complex environments, all of which require rapid communication between sensory, motor, and cognitive networks. Here, we measured neuromagnetic brain activity to investigate the neural timing of cortical areas needed for inhibitory control, while 14 healthy young adults performed an interleaved prosaccade (look at a peripheral visual stimulus) and antisaccade (look away from stimulus) task. Analysis of how neural activity relates to saccade reaction time (SRT) and occurrence of direction errors (look at stimulus on antisaccade trials) provides insight into inhibitory control. Neuromagnetic source activity was used to extract stimulus-aligned and saccade-aligned activity to examine temporal differences between prosaccade and antisaccade trials in brain regions associated with saccade control. For stimulus-aligned antisaccade trials, a longer SRT was associated with delayed onset of neural activity within the ipsilateral parietal eye field (PEF) and bilateral frontal eye field (FEF). Saccade-aligned activity demonstrated peak activation 10ms before saccade-onset within the contralateral PEF for prosaccade trials and within the bilateral FEF for antisaccade trials. In addition, failure to inhibit prosaccades on anti-saccade trials was associated with increased activity prior to saccade onset within the FEF contralateral to the peripheral stimulus. This work on dynamic activity adds to our knowledge that direction errors were due, at least in part, to a failure to inhibit automatic prosaccades. These findings provide novel evidence in humans regarding the temporal dynamics within oculomotor areas needed for saccade programming and the role frontal brain regions have on top-down inhibitory control.
Thulium sensitised holmium-doped CW fluoride fibre laser of high efficiency (1992)

CW operation of extremely high efficiency has been observed from the 2.024 μm transition of holmium in a Tm: Ho codoped singlemode fluoride fibre laser. By pumping into thulium absorption between 820 and 830 nm, output powers of 250 mW and maximum slope efficiencies of 60 % were observed. These results suggest that pump quantum, and photon conversion efficiencies of 150 and 75 % respectively, are readily attainable.
Microstructure Abnormalities in Adolescents with Internet Addiction Disorder (2011)

Our results suggested that long-term internet addiction would result in brain structural alterations, which probably contributed to chronic dysfunction in subjects with IAD. The current study may shed further light on the potential brain effects of IAD.
Applications notes - Robust route optimization for gritting/salting trucks: A CERCIA experience (2006)

Highway authorities in marginal winter climates are responsible for the precautionary gritting/salting of the road network in order to prevent frozen roads. For efficient and effective road maintenance, accurate road surface temperature prediction is required. However, this information is useless if an effective means of utilizing this information is unavailable. This is where gritting route optimization plays a crucial role. The decision whether to grit the road network at marginal nights is a difficult problem. The consequences of making a wrong decision are serious, as untreated roads are a major hazard. However, if grit/salt is spread when it is not actually required, there are unnecessary financial and environmental costs. The goal here is to minimize the financial and environmental costs while ensuring roads that need treatment will. In this article, a salting route optimization (SRO) system that combines evolutionary algorithms with the neXt generation Road Weather Information System (XRWIS) is introduced. The synergy of these methodologies means that salting route optimization can be done at a level previously not possible.
Video from earth orbiting satellites (for oceanographers) (2015)

This paper reviews video capabilities from Earth orbiting satellites and applications to ocean remote sensing. Videos for purpose of this paper are sequences of images on a fixed location with frame rates in the range of 0.1 to 30 Hz. The number of video capable satellites is increasing. Applications include directional wave spectra, ocean surface currents, surf zone dynamics, and others. Some applications are illustrated, and others are suggested for future research.