gebhart/patrepeval huggingface dataset:
Data center resilience assessment : storage, networking and security. (2011)

Data centers (DC) are the core of the national cyber infrastructure. With the incredible growth of critical data volumes in financial institutions, government organizations, and global companies, data centers are becoming larger and more distributed posing more challenges for operational continuity in the presence of experienced cyber attackers and occasional natural disasters. The main objective of this research work is to present a new methodology for data center resilience assessment, this methodology consists of: • Define Data center resilience requirements. • Devise a high level metric for data center resilience. • Design and develop a tool to validate and the metric. Since computer networks are an important component in the data center architecture, this research work was extended to investigate computer network resilience enhancement opportunities within the area of routing protocols, redundancy, and server load to minimize the network down time and increase the time period of resisting attacks. Data center resilience assessment is a complex process as it involves several aspects such as: policies for emergencies, recovery plans, variation in data center operational roles, hosted/processed data types and data center architectures. However, in this dissertation, storage, networking and security are emphasized. The need for resilience assessment emerged due to the gap in existing reliability, availability, and serviceability (RAS) measures. Resilience as an evaluation metric leads to better proactive perspective in system design and management. The proposed Data center resilience assessment portal (DC-RAP) is designed to easily integrate various operational scenarios. DC-RAP features a user friendly interface to assess the resilience in terms of performance analysis and speed recovery by collecting the following information: time to detect attacks, time to resist, time to fail and recovery time. Several set of experiments were performed, results obtained from investigating the impact of routing protocols, server load balancing algorithms on network resilience, showed that using particular routing protocol or server load balancing algorithm can enhance network resilience level in terms of minimizing the downtime and ensure speed recovery. Also experimental results for investigating the use social network analysis (SNA) for identifying important router in computer network showed that the SNA was successful in identifying important routers. This important router list can be used to redundant those routers to ensure high level of resilience. Finally, experimental results for testing and validating the data center resilience assessment methodology using the DC-RAP showed the ability of the methodology quantify data center resilience in terms of providing
Heterodyne temporal speckle-pattern interferometry (2000)

In temporal speckle-pattern interferometry deformation information is extracted by a Fourier transform technique from the speckle pattern that is recorded over a period of time as the object is deformed. A limitation of the experimental arrangements reported to date is that the direction of the deformation cannot be determined. We propose removing this limitation by using the heterodyne principle. Some experimental results that were obtained by use of a rotating half-wave-plate frequency shifter are presented.
An imaging technique using confocal circular synthetic aperture radar (1998)

This paper presents a theory and its experimental demonstration of an imaging technique based on three-dimensional (3D) space-time confocal imaging and circular synthetic aperture radar (SAR). The theory is an extension of the conventional straight-path SAR-to-SAR on an arbitrary curved path. Next, a general formulation for the curved SAR is applied to circular SAR geometry, which has two important features. First, it allows the maximum attainable resolution to be an the order of a wavelength. Second, it makes 3D confocal imaging possible, X-band (7-13 GHz) imaging experiments are conducted to demonstrate this technique.
Nondestructive Inspection Using Rotating Magnetic Field Eddy-Current Probe (2011)

Rotating magnetic field eddy-current (RoFEC) probe for nondestructive evaluation of steam generator tubes in a nuclear power plant offers an alternate method that has compact configuration and higher speed compared to traditional bobbin coil, rotating probe coils, and array probes. This paper investigates the feasibility of the proposed RoFEC eddy-current probe which is composed of three windings excited by three-phase ac current and does not require mechanical rotation of probe. Results of finite-element modeling using reduced magnetic vector potential (RMVP) formulation are presented for modeling the inspection of ferromagnetic and nonferromagnetic tubes. Design parameters of the excitation coils and GMR pick-up sensor are optimized by means of a parametric study.
Optimization of a Human Papillomavirus-Specific Enzyme-Linked Immunosorbent Assay (2002)

ABSTRACT A strategy was developed for the control, standardization, and critical evaluation of an enzyme-linked immunosorbent assay (ELISA) for the detection of human papillomavirus-specific immunoglobulin G in human sera. Control human sera, polyclonal animal sera, and monoclonal antibodies were used to establish optimal assay parameters, including antigen coating, serum dilutions, and criteria for daily reproducibility, monitoring, and rejection of assays. Three evaluation techniques were used in parallel to define an optimal cutoff absorbance value that yields greater than 93% sensitivity and 98.5% specificity in the assay's ability to discriminate positive and negative control sera. This strategy provides an optimal method by which to determine cutoff absorbance values for ELISA.
An Enhanced Semantic Layer for Hybrid Recommender Systems (2011)

Recommender systems have achieved success in a variety of domains, as a means to help users in information overload scenarios by proactively finding items or services on their behalf, taking into account or predicting their tastes, priorities, or goals. Challenging issues in their research agenda include the sparsity of user preference data and the lack of flexibility to incorporate contextual factors in the recommendation methods. To a significant extent, these issues can be related to a limited description and exploitation of the semantics underlying both user and item representations. The authors propose a three-fold knowledge representation, in which an explicit, semantic-rich domain knowledge space is incorporated between user and item spaces. The enhanced semantics support the development of contextualisation capabilities and enable performance improvements in recommendation methods. As a proof of concept and evaluation testbed, the approach is evaluated through its implementation in a news recommender system, in which it is tested with real users. In such scenario, semantic knowledge bases and item annotations are automatically produced from public sources.
A disturbance of the IL-2/IL-2 receptor system parallels the activity of multiple myeloma. (1991)

The IL-2/IL-2 receptor (IL-2R) system has been investigated in 64 patients with multiple myeloma (MM), 31 with monoclonal gammopathies of undetermined significance (MGUS) and 20 normal controls. The MM data were related to clinical status by comparing active disease, i.e. at diagnosis and at relapse, and stable disease, i.e. complete remission and off-treatment plateau phase. Serum and urinary values of the soluble IL-2R (sIL-2R) were significantly increased in MM patients compared with normal controls and this increase was related to activity. MM patients with active disease gave significantly higher values than those with stable disease. Compared with normal controls, enriched B cell (but not T cell) preparations from peripheral blood mononuclear cells (PBMC) showed significantly increased proportions of IL-2R+ cells in MM and MGUS. However, the highest proportions were detected in active MM compared with stable MM and MGUS. Also, 16% of all MM patients, as opposed to 9% of MGUS, had well-defined bone marrow IL-2R+ plasma cell populations. The lowest serum IL-2 values were found in active MM. Serial follow up of serum sIL-2R suggested that this peptide can be used as an additional marker of active malignancy. The data indicate that a disturbance of IL-2/IL-2R system is most pronounced in active MM. These findings may provide clues as to the T cell abnormalities in MM.
Novel Triterpene Sulfates from Fusarium compactum Using a Rhinovirus 3C Protease Inhibitor Screen. (1996)

Two novel triterpene sulfates have been isolated from Fusarium compactum by bioactivity-directed fractionation using an assay which measures the inhibition of proteolytic activity of rhinovirus 3C protease on a fluorogenic peptide substrate. The compounds were purified by countercurrent and reverse phase chromatographies. NMR, MS, UV and IR studies revealed two triterpene sulfates, uncommon metabolites of terrestrial fungi.
Ion beam processes in advanced electronic materials and device technology (1985)

These proceeding collect papers on ion beams and materials science. topics include: amorphous silicon layer regrowth, damage induced by ion implantation, magnetic properties of implantedious, formation of amorphous silicon by ion damage, ion beam mixing, hydrogen ion beam passivation of electrically active defects in soar cells, and annealing of silicon and beryllium-implanted gallium arsenide.
Human Glioma Cell Sensitivity to the Sequence-Specific Alkylating Agent Methyl-Lexitropsin (2007)

(a) Me-lex is cytotoxic in human glioma cells and AAG promotes resistance, indicating that 3-meA is a lethal lesion in these cells. (b) Abasic sites resulting from 3-meA repair are cytotoxic and Ape1 promotes resistance to these derivative lesions. (c) A factor(s) associated with MGMT expression, other than repair of O(6)-meG, contributes to Me-lex resistance. (d) Me-lex may have clinical utility in the adjuvant therapy of gliomas. (e) AAG and Ape1 inhibitors may be useful in targeting alkylating agent resistance.
A Framework of Time, Place, Purpose and Personal Profile Based Recommendation Service for Mobile Environment (2005)

Nowadays more people have started using their mobile phone to access information they need from anywhere at anytime. In advanced mobile technology, Location Service allows users to quickly pinpoint their location as well as makes a recommendation to fascinating events. However, users desire more appropriate recommendation services. In other words, the message service should push a message at a proper place in time. In consequence, customers obtain a higher level of satisfaction. In this paper, we propose a framework of time, place, purpose and personal profile based recommendation service. We illustrate scenarios in push, pull and don't disturb services, where our DB queries can recommend the relevant message to users. The three factors: time, place and purpose are mutually dependent and the basic rules to analyze the essential data are summarized. We also create algorithms for DB query. We are filtering messages by one important factor: personal profile such as user's preference and degree of preference. Furthermore, we discuss an implementation of the prototype system, including results of experimental evaluation.
Controlling the shape and gap width of silicon electrodes using local anodic oxidation and anisotropic TMAH wet etching (2012)

Controlling the shape and gap width of silicon electrodes using local anodic oxidation and anisotropic TMAH wet etching, Rouhi, Jalal, Mahmud, Shahrom, Hutagalung, Sabar Derita, Naderi, Nima, Kakooei, Saeid, Abdullah, Mat Johar
Enhanced Adenovirus Infection of Melanoma Cells by Fiber-Modification (2003)

The incidence of malignant melanoma has been increasing. Unfortunately, advanced melanomas are rarely curable with standard therapy; therefore, new forms of treatment such as gene therapy are needed. The success of gene delivery or oncolysis depends on the nature of the vector. Adenoviral vectors are advantageous for several reasons; however, they are dependent on CAR (coxsackie and adenovirus receptor) which is deficient or heterogeneously expressed on melanoma cells in situ. Correspondingly, transduction of freshly purified melanoma cells has been shown to be minimal or variable. In order to overcome this shortcoming, it is necessary to construct tropism modified adenoviral vectors. With this goal in mind, we generated two tropism modified vectors, Ad5lucRGD which has an RGD motif incorporated into the HI loop of the fiber knob and Ad5/3luc1 which contains the tail and shaft domain of the Ad5 fiber and the knob domain of the Ad3 fiber. Herein we demonstrate that Ad5/3luc1 infects CAR-negative primary melanoma cells 1128 times better than Ad5luc1 and 34 times better than Ad5lucRGD. Furthermore we show that Ad5/3luc1 and Ad5lucRGD infect via a CAR independent route by blocking the CAR receptor. In addition, we show that the infectivity of the cells correlates with the expression of CAR and Ad3 receptors determined by FACS analysis. Therefore, Ad5/3 is very attractive as a potential therapeutic vector for malignant melanoma.
Cbp recruitment of Csk into lipid rafts is critical to c-Src kinase activity and bone resorption in osteoclasts (2009)

A tyrosine kinase, c-Src, that plays an indispensable role in ruffled border formation and bone resorption is constitutively active in osteoclasts. However, to date, the molecular mechanism underlying increased c-Src activity in osteoclasts is unknown. To address this, we first examined the expression levels and subcellular localization of Csk, a negative regulatory kinase for c-Src. We found that the expression level of Csk in osteoclasts was comparable with that of other tissues. However, in osteoclasts, Csk was hardly localized in lipid rafts, where c-Src is highly expressed. Interestingly, expression of Cbp, which recruits Csk into lipid rafts through physical interaction with Csk, was very low in osteoclasts compared with other tissues. To understand the importance of Cbp in osteoclasts, we introduced Cbp into osteoclasts using an adenovirus gene delivery system. Introduction of Cbp stimulated recruitment of Csk into lipid rafts and suppressed c-Src activity in a dose-dependent manner. Furthermore, introduction of Cbp markedly inhibited formation of actin rings and bone-resorbing activity in osteoclasts. In addition, treatment with RANKL and overexpression of TRAF6 or NFAT2 inhibited Cbp expression in the osteoclastogenic cell line RAW264.7 along with osteoclastic differentiation. NFAT2 overexpression also inhibited Cbp expression in spleen macrophages. Collectively, our results indicate that reduction in Cbp expression is responsible for maintaining high c-Src activity in osteoclasts. These findings contribute to an understanding of the unique regulatory system for c-Src in osteoclasts.
Transfer, Incorporation, and Substitution of Envelope Fusion Proteins among Members of the <i>Baculoviridae</i> , <i>Orthomyxoviridae</i> , and <i>Metaviridae</i> (Insect Retrovirus) Families (2002)

Recent research suggests that members of the Baculoviridae family can be divided into two groups on the basis of their envelope fusion proteins (31). One group utilizes proteins related to GP64. Homologs of GP64 are also used by the thogotoviruses (27), a genus of the Orthomyxoviridae family. Members of the other group of baculoviruses utilize envelope fusion proteins related to a protein called LD130. LD130 has been shown to be related to the envelope protein of insect retroviruses in the genus Errantivirus (family Metaviridae) (24, 36). In this review, the evidence for these data is outlined and possible pathways of transfer, incorporation, and substitution are discussed.
Vision-based bin picking system for industrial robotics applications (2012)

The vision-based bin picking using object recognition has been considered as an innovative manufacturing process in industrial robotics applications. In bin picking system, pick and place tasks are performed by robot which has been processed by measuring object pose. But it has to address challenge problems such as object appearance distorted by overlapping parts, lighting variation or reflection, picking from randomly piled parts in a bin. This research is to investigate a vision-based bin-picking method, which provides a robust and efficient method to recognize object and to estimate pose with multiple vision sensors.
Leveraging Cloud Native Design Patterns for Security-as-a-Service Applications (2017)

This paper discusses a new approach for designing and deploying Security-as-a-Service (SecaaS) applications using cloud native design patterns. Current SecaaS approaches do not efficiently handle the increasing threats to computer systems and applications. For example, requests for security assessments drastically increase after a high-risk security vulnerability is disclosed. In such scenarios, SecaaS applications are unable to dynamically scale to serve requests. A root cause of this challenge is employment of architectures not specifically fitted to cloud environments. Cloud native design patterns resolve this challenge by enabling certain properties e.g. massive scalability and resiliency via the combination of microservice patterns and cloud-focused design patterns. However adopting these patterns is a complex process, during which several security issues are introduced. In this work, we investigate these security issues, we redesign and deploy a monolithic SecaaS application using cloud native design patterns while considering appropriate, layered security counter-measures i.e. at the application and cloud networking layer. Our prototype implementation out-performs traditional, monolithic applications with an average Scanner Time of 6 minutes, without compromising security. Our approach can be employed for designing secure, scalable and performant SecaaS applications that effectively handle unexpected increase in security assessment requests.
New equations for estimating body cell mass from bioimpedance parallel models in healthy older Germans (2001)

The objectives of this study were to assess for elderly Germans the validity of existing equations for predicting body cell mass (BCM) and to develop from single- and multifrequency bioimpedance (SFBIA, MFBIA) models new prediction equations. In a data-splitting approach, validation and cross-validation were performed in 160 healthy elderly (60- to 90-yr) subjects. BCM was determined using a tetrapolar bioimpedance analyzer (800 microA; 4 fixed frequencies: 1, 5, 50, and 100 kHz; electrodes placed to hand, wrist, ankle, and foot) and whole body (40)K counting as a reference method. New prediction equations were derived by multiple stepwise regression analysis. The Bland-Altman procedure was used for methods comparison. Relative to whole body counting, the manufacturer's equation overestimated BCM by 9% in men (P < 0.0001, paired t-test) and 4% in women (P = 0.002). Compared with the manufacturer's equation, the newly derived equations (r = 0.92, RMSE = 6-9%) improved accuracy (pure error = 13 vs. 7-8%) and reduced bias and limits of agreement. SFBIA and MFBIA equations did not differ in precision or accuracy. We conclude that the newly derived equations improved BCM estimates in the elderly compared with existing equations. There was no advantage of MFBIA over SFBIA equations.
Somatostatin analogue treatment of neuroendocrine tumours (1996)

The long-acting analogues of somatostatin have an established place in the medical treatment of patients with neuroendocrine tumours. They act through binding with specific, high-affinity membrane receptors. Somatostatin analogue therapy is an effective and safe treatment for most growth hormone and thyrothropin-secreting pituitary adenomas. The potential therapeutic consequences of the presence of somatostatin receptors on clinically 'nonfunctioning' pituitary tumours are still uncertain. Somatostatin analogues are not useful in the treatment of patients with prolactinomas, or adrenocorticotropin (ACTH)-secreting adenomas. However, the somatostatin analogue octreotide suppressed pathological ACTH release in some patients with Nelson's syndrome and ACTH and cortisol secretion in several patients with Cushing's syndrome caused by ectopic ACTH secretion. Somatostatin analogues are effective in the sympatomatic treatment of most (metastatic) pancreatic islet cell tumours and most (metastatic) carcinoids. In some of these patients, they also induce tumour stabilisation or reduction. In some patients with (metastatic) medullary thyroid carcinomas, continuous treatment with very high doses of octreotide can be of temporary relief. The clinical effectiveness of somatostatin analogues in patients with small cell lung cancer is currently under investigation. Long-term therapy with somatostatin analogues of catecholamine-secreting (malignant) paragangliomas and phaeochromocytomas has not shown clinical benefits.
Polysilicon 3D-mirror frequency shifter for WDM fibre-optic communication applications (2002)

This paper reports the design, fabrication, and testing of a monolithic integrated frequency shifter device using movable 3D-mirror to enable channel selection for WDM optics communication applications. The modification of Fabry-Perot microcavity length is implemented by micromechanical electrostatic actuators to enable a wide channel selection. The wavelength shifter is able to tune wavelength around 1.525-1.575 /spl mu/m to achieve the requirements of optical telecommunication band, and the flat transmission characteristic with low insertion losses over maximal wavelength range and minimal interchannel crosstalk between the coexisting transmission channels. Compared with the membrane mirror type of frequency shifter, the movable 3D-mirror frequency shifter overcomes the influence of residual stress within the membrane layers.
Characterization of Alteromonas denitrificans sp. nov. (1987)

Eleven strains of gram-negative, denitrifying, prodigionine-producing marine bacteria with sheathed flagella were recovered from the fjord system off the Norwegian west coast. These isolates form a physiologically and morphologically very homogeneous group. Apart from their ability to denitrify and having sheathed flagella, the strains correspond closely to the current description of the genus Alteromonas. Their strictly respiratory metabolism precludes their inclusion in the genus Vibrio, and the low guanine-plus-cytosine contents of their deoxyribonucleic acids preclude their inclusion in the genus Pseudomonas or the genus Marinomonas. Despite their ability to denitrify, we suggest that these organisms belong to the genus Alteromonas and constitute a new species, Alteromonas denitrificans. A detailed description of the type strain of Alteromonas denitrificans, Nygaard 1977, is given. The type strain has been deposited with the American Type Culture Collection, Rockville, Md., as strain ATCC 43337.