gebhart/patrepeval huggingface dataset:
Discrete-time adaptive windowing for velocity estimation (2000)

We present methods for velocity estimation from discrete and quantized position samples using adaptive windowing. Previous methods necessitate trade-offs between noise reduction, control delay, estimate accuracy, reliability, computational load, transient preservation, and difficulties with tuning. In contrast, a first-order adaptive windowing method is shown to be optimal in the sense that it minimizes the velocity error variance while maximizes the accuracy of the estimates, requiring no tradeoff. Variants of this method are also discussed. The effectiveness of the proposed technique is verified in simulation and by experiments on the control of a haptic device.
The oesophageal detector device (1988)

A new method to distinguish oesophageal from tracheal intubation using the oesophageal detector device was evaluated. In 100 healthy adults, observers of differing experience reliably and rapidly detected 51 oesophageal and 49 tracheal intubations in a randomised, single-blind trial. In one case, blockage of the tracheal tube was detected swiftly and allowed corrective steps to be taken. This method can be used in patients with bronchospasm to detect correct tracheal placement when auscultation and decreased compliance of the chest may make clinical confirmation difficult. It can be concluded from this study that the oesophageal detector device is a reliable, rapid, inexpensive and easy to use method for the detection of oesophageal intubation and its very low cost should make it readily available in all situations where tracheal intubation is carried out.
Serum Ferritin in the Evaluation of Iron Status in Young Healthy Women (1980)

The iron stores of 17 healthy young women were evaluated by a serum ferritin assay and by bone marrow iron determinations. Iron stores were absent or scanty in about 70% of subjects. A high degree of correlation was demonstrated between serum ferritin concentration and bone marrow iron stores. The mean serum ferritin level in women with absent iron stores was 26 μg/l, compared with 114 μg/l in women with sufficient bone marrow iron stores. Repeated measurements of serum ferritin, iron, transferrin and blood hemoglobin during the menstrual cycle revealed no significant changes in these parameters.
Multi-Band Sensing for Dielectric Property of Chemicals Using Metamaterial Integrated Microfluidic Sensor (2018)

The growth of the chemical industry has brought tremendous challenges to chemical sensing technology. Chemical sensors based on metamaterials have great potential because of their label-free and non-destructive characteristics. However, metamaterials applied in chemical sensing have mainly been investigated from the measurement of sample concentration or the determination of the dielectric properties at a fixed frequency. Here we present a metamaterial integrated microfluidic (MIM) sensor for the multi-band sensing for dielectric property of chemicals, which is promising for the identification of chemicals. The MIM sensor mainly consists of multiple pair of high sensitive symmetrical double split-ring resonators (DSRRs) and meandering microfluidic channels with a capacity of only 4 μL. A dielectric model has been innovatively established and experimentally verified to accurately estimate the complex permittivity and thus realize the multi-band sensing of dielectric property of chemicals. With the increase in the number of resonators in the sensor, a dielectric spectrum like curve could be obtained for more detailed dielectric information. This work delivers a miniaturized, reusable, label-free and non-destructive metamaterial-microfluidic solution and paves a way of the multi-band sensing for dielectric property of chemicals.
Scintigraphic imaging of focal hypoxic tissue: development and clinical applications of 123I-IAZA (2002)

Affected tissues in a number of diseases, including cancer, stroke, cardiac infarction and diabetes, develop focal tissue hypoxia during their progression. The presence of hypoxic tissue may make the disease refractory to therapy, as in the case of solid tumor therapy using low LET ionizing radiation. In other pathologies, the detection of viable but hypoxic tissues may serve as a prodromal indicator of developing disease (e.g. diabetes),or as a prognostic indicator for management of the disease (e.g. stroke). Over the past two decades, a number of hypoxia radioimaging agents have been developed and tested clinically. Of these, 18F-Fmiso and 123I-IAZA are the most widely used radiotracers for PET and SPECT/planar imaging, respectively. IAZA and Fmiso are a 2-nitroimidazoles that chemically bind to subcellular components of viable hypoxic tissues. They sensitize hypoxic tumour to the killing effects of ionizing radiation via mechanisms that mimic the radiosensitizing effects of oxygen, and are therefore called oxygen mimetics. The oxygen mimetic effect is attributable in large part to the covalent binding of reductively-activated nitroimidazole intermediates to critical cellular macromolecules. Nitroimidazoles labelled with gamma-emitting radionuclides (e.g. 18F-Fmiso and 123I-IAZA) have been used as scintigraphic markers of tumour hypoxia, based on the need to identify radioresistant hypoxic tumour cells as part of the radiotherapy planning process. Broader interest in non-invasive, imaging-based identification of focal hypoxia in a number of diseases has extended hypoxia studies to include peripheral vascular disease associated with diabetes, rheumatoid arthritis, stroke, myocardial ischaemia, brain trauma and oxidative stress. In this review, the current status of hypoxia-selective studies with 123I-IAZA , an experimental diagnostic radiopharmaceutical, is reviewed with respect to its pre-clinical development and clinical applications.
Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in <i>BRAF</i> <sup> <i>V600E</i> </sup> melanoma (2015)

Combining immunotherapy and BRAF targeted therapy may result in improved antitumor activity with the high response rates of targeted therapy and the durability of responses with immunotherapy. However, the first clinical trial testing the combination of the BRAF inhibitor vemurafenib and the CTLA4 antibody ipilimumab was terminated early because of substantial liver toxicities. MEK [MAPK (mitogen-activated protein kinase) kinase] inhibitors can potentiate the MAPK inhibition in BRAF mutant cells while potentially alleviating the unwanted paradoxical MAPK activation in BRAF wild-type cells that lead to side effects when using BRAF inhibitors alone. However, there is the concern of MEK inhibitors being detrimental to T cell functionality. Using a mouse model of syngeneic BRAF(V600E)-driven melanoma, SM1, we tested whether addition of the MEK inhibitor trametinib would enhance the antitumor activity of combined immunotherapy with the BRAF inhibitor dabrafenib. Combination of dabrafenib and trametinib with pmel-1 adoptive cell transfer (ACT) showed complete tumor regression, increased T cell infiltration into tumors, and improved in vivo cytotoxicity. Single-agent dabrafenib increased tumor-associated macrophages and T regulatory cells (Tregs) in tumors, which decreased with the addition of trametinib. The triple combination therapy resulted in increased melanosomal antigen and major histocompatibility complex (MHC) expression and global immune-related gene up-regulation. Given the up-regulation of PD-L1 seen with dabrafenib and/or trametinib combined with antigen-specific ACT, we tested the combination of dabrafenib, trametinib, and anti-PD1 therapy in SM1 tumors, and observed superior antitumor effect. Our findings support the testing of triple combination therapy of BRAF and MEK inhibitors with immunotherapy in patients with BRAF(V600E) mutant metastatic melanoma.
The Fate of Iron in The Organism and Its Regulatory Pathways (2005)

Iron is an essential element involved in many life-necessary processes. Interestingly, in mammals there is no active excretion mechanism for iron. Therefore iron kinetics has to be meticulously regulated. The most important step for regulation of iron kinetics is absorption. The absorption takes place in small intestine and it is implicated that it requires several proteins. Iron is then released from enterocytes into the circulation and delivered to the cells. Iron movement inside the cell is only partially elucidated and its traffic to mitochondia is not known. Surprisingly, the regulation of various proteins related to iron kinetics and energy metabolism at the molecular level is better described. On contrary, the complex control of iron absorption cannot be fully explicated with present knowledge.
Echinococcosis in dogs in urban and rural areas in Dakahlia Governorate, Egypt. (2007)

A sample of one hundred and ninety stray dogs was captured from Mansoura city (urban) and three hundreds and fifty stray dogs were captured from Meet El-Korama, Mansheit El-Badawy villages (rural). The total prevalence of E. granulosus was 5%, with a worm burden ranging from 4 to 1010 (mean = 421). The significant prevalence was 6% in the rural area and 3.2% in the urban one. E. granulosus showed higher prevalence in young than old dogs and in males than females but without significant difference in both variants. The overall Echino-ELISA sensitivity was 61.5% and specificity was 97.5%. The major cross reactivity was with Taenia spp., and Diplydium caninum, but neither with Toxocara canis or Trichurus vulpis nor Ancylostoma caninum. There was a negative correlation between ELISA and Echinococcus granulosus burden in dogs.
Pharmacological, Microbiological and Clinical Activity of Feminine Intimate Cleansers Based on Plant Extracts Active Principles (Saugella Line) (2015)

Introduction: The use in intimate hygiene of active substances plays an important role in maintaining the balance of the vaginal ecosystem. The most medically based cleansers are promoted to doctors through a classic medical information, even if classified as cosmetics. The present paper assessed the reliability of the pharmacological, microbiological and clinical claims both on the active principles of Salvia officinalis, Thymus vulgaris, Camomilla recutita and Calendula officinalis extracts, contained in the most used hygiene product line. 
Methods: The experimental activity was studied on the inhibition of microbes’ adhesion to human vaginal epithelial cells, morphostructural damages to germ cells, inhibition of microbial biofilms, and anti-inflammatory tests. The clinical data were collected according to the use recommendation as daily intimate cleanser, uid or bid for four weeks: salvia (SD - Saugella Dermoliquido) in fertile age women, thymus (SA – S. Attiva) in pregnancy, breastfeeding and risk of vulvovaginal infection, chamomile (SP – S. Poligyn) in postmenopausal women, calendula (SG – S. Girl) in pre-adolescent girls prone to vaginal irritations. At baseline and after 4-week treatment, vaginal pH, signs/symptoms, and sexual activity were evaluated. 
Results: The experimental data showed the antibacterial, antimycotic, anti-inflammatory and antioxidant activity of the natural principles contained in the four extracts. The clinical studies evidenced the significant reduction of genital signs and symptoms (itching, burning, erythema, edema, vaginal dryness, dyspareunia) and the improvement of sexual female disorder. 
Conclusions: Correct intimate hygiene improves quality of woman’s life and can prevent minor vulvo-vaginal pathologies. The cleanser selection should be tailored on the age and physiopathological condition of the woman. The claims of efficacy and safety that supports the recommendation of the use in daily practice of the Saugella line products containing Salvia, Thymus, Chamomile, and Calendula extracts are consistent and reliable.
Acoustic-surface-wave dispersive delay line (1969)

The requirements for a dispersive delay line, for pulse-compression radar, capable of operating at v.h.f. and microwave frequencies, suggest the use of an acoustic-surface-wave system. The basic structure consists of a thin film supported on a substrate. It is shown how a required delay characteristic can be synthetised by tapering the thickness of the film. Experiments carried out at relatively low frequencies are in good agreement with the theoretical results produced by the synthesis programme. The attainment of a high compression ratio demands a very precise control, and hence measurement, of the dispersion characteristic. A new technique which is capable of achieving the required precision has been developed. It is based on a continuous-wave (c.w.) bridge method, in which a small modulation of the surface wave enables one to achieve a very high discrimination against spurious modes. The materials problems for high-frequency delay lines are discussed, and a number of suggestions based on computer analysis are advanced.
UNIX Fault Management: A Guide for System Administrators (1999)

Maximize UNIX system integrity and availability in mission-critical environments!If you're responsible for maintaining the integrity and availability of a mission-critical UNIX system, then you need UNIX Fault Management: A Guide for System Administrators, the first book that brings together all of the monitoring and fault management information. Expert UNIX system management engineers Brad Stone and Julie Symons show you exactly how to implement appropriate, cost-effective system monitoring on any UNIX server -- including systems configured as high availability clusters. You'll learn how to: Plan for-and establish-cost-effective, reliable system monitoring procedures Monitor systems, disks, networks, applications, and databases Detect, investigate, and recover from server problems Implement best practices for high availability in enterprise-class UNIX installations-including clusters Take advantage of key fault management trends, new standards, and new technologiesThis book contains detailed descriptions of fault monitoring tools and monitoring frameworks to help you make better purchasing decisions. You'll also find a handy quick reference of monitoring tasks and techniques for operators -- including specific, step-by-step recovery solutions. If you can't afford one nanosecond more downtime than necessary, you can't afford to be without UNIX Fault Management.
Improved detection of landmarks on 3D human face data (2013)

Craniofacial researchers make heavy use of established facial landmarks in their morphometric analyses. For studies on very large facial image datasets, the standard approach of manual landmarking is very labor intensive. With the goal of producing 20 established landmarks, we have developed a geometric methodology that can automatically locate 10 established landmark points and 7 other supporting points on human 3D facial scans. Then, to improve accuracy and produce all 20 landmarks, a deformable matching procedure establishes a dense correspondence from a template 3D mesh with a full set of 20 landmarks to each individual 3D mesh. The 17 geometrically-determined points on the individual 3D mesh are used for the initial correspondence required by the deformable matching. The method is evaluated on 115 3D facial meshes of normal adults, and results are compared to landmarks manually identified by medical experts. Our results show a marked improvement to prior results in the recent literature.
Superoxides: Alternative Oxidants for the Oxidative Desulfurization Process (2008)

Superoxides, for instance, potassium superoxide, have been demonstrated as alternative oxidants for the oxidative desulfurization process. For model compounds of benzothiophene, dibenzothiophene, and a number of selected diesel oil samples, sulfur removal greater than 90% and as high as 99% was accomplished. The results for using this solid potassium superoxide are comparable to or better than the results with liquid hydrogen peroxide for the ultrasound-assisted oxidative desulfurization (UAOD) or oxidative desulfurization (ODS) process. This solid oxidant can highly reduce the weight of oxidant dose, reactor volume, storage, and transport/shipment requirements. For the first time, the feasibility of desulfurization for high sulfur containing heavy oil with sulfur content greater than 1% has been demonstrated.
Simulation models for evaluation of network design and hierarchical transactive control mechanisms in Smart Grids (2012)

Smart-grid technologies seek to enhance the electrical grid's efficiency by introducing bi-directional communication and dynamic adaptive control between energy suppliers and consumers. We develop a large-scale network simulation model for evaluating such a hierarchical transactive control system that is part of our work on the Pacific Northwest Smart Grid Demonstration Project. The transactive control system communicates local supply conditions using incentive signals and load adjustment responses using feedback signals in a distributed fashion in order to match the consumer-desired load to the utility-desired supply scenario. We study the system protocol and a dynamic control mechanism that is implied by the design under a reasonable collection of models that capture load variation, stochastic signal losses, consumer fatigue to demand response and certain `stickiness' criterion on the control signals that arise out of physical constraints. Our results indicate that the control mechanism can perform adequately in adjusting the aggregate supply-demand mismatch, and is robust to steady transactive signal losses.
Arithmetic Codes in Residue Number Systems with Magnitude Index (1978)

The idea of adding a magnitude index to the residue representation of numbers is reconsidered. The range of a given residue number system is supposed to be divided into intervals of equal width, and the magnitude index of a number X is defined as an integer locating X into one of such intervals. It is shown that the redundancy implied by the use of the magnitude index allows error detection or correction, and the redundancy requirements to detect or correct single residue digit errors are the same as in redundant residue number systems and in product codes in residue number systems. In addition, these codes allow detection of any error affecting the residue representation, provided that the magnitude of the error exceeds a given threshold, and, whenever an error is detected, it is possible to replace the wrong number with an approximation of the correct number.
???Nurse???: Dynamic Terms for a Dynamic Relationship (1992)

1A Clinical Nurse Specialist in Gerontology at The Kenney Presbyterian Home in Seattle, Washington at the time this article was written. Currently she is a Research Associate in General Internal Medicine, Seattle Veterans Affairs Medical Center, Seattle, Washington 2Self-employed
Educational Policy and the Australian Rural Economy (1994)

As in the past, the 1990s Australian economy continues to be shaped by external pressures: now,as part of theglobalisation of internationalindustry, trade, andfinance. Intensified byglobal recession, tradewars,and poor commodity prices, this process has contributed to aprolonged crisis in Australian agriculture and communities. The Australian government has adopted policies of rationalisation, deregulation, and privatisation in relation to bothrural industries and the provisionof educationand training. The new educationand training agenda has implications for ruralpeople. While government policy for education in areas in the past has included both generic and targetted policy initiatives, these have recently converged: Rural policies increas­ ingly reflect the newagenda. The newapproach may not fully benefit ruralpeople, however, as it is based on urban models that may neglect the specificneeds and constraints of ruralareas. The articles in this issue of JRRE provide a comprehensive overview of the key issues affect­ ing the education of Australians. We can point to some of the more pressing policy areas. These include: the staffing of and remote schools; the challenges posed by geographic and social isolation; the inequalities of educational provision and outcomes (especially school reten­ tion rates); the specific challenges of Aboriginal disadvantage and educational provision; the con­ tent of curricula; the problems of educa­ tional provision for special groups; the relation­ ship between and generic education; the particular problems of technical and further edu­ cation; and the intricate connections between edu­ cation, employment, income support, housing, and transport. (For recent discussions of these and related issues, see Boylan & Alston, 1993; Quixley, 1992.) Federal and state governments in Australia have responded in diverse ways, and with vary­ ing levels of efficacy, to these challenges. The diversity of programs established by the eight. state and territory governments would require considerable space to discuss; here, we confine our examination to national (federal) initiatives. To understand the nature of educational policy and provision in Australia, it is necessary to appreciate the historical development of the economy, particularly as it has taken place within the global food and fibre producing regimes. We first sketch out key aspects of this global context. We then examine the ways in which the realities of Australia's economic development and current position have been reflected in particular national educational policies. We examine some specifi­ cally rural initiatives and then turn our atten­ tion to overarching national policies that will im­ pact on people. We conclude that the current national agenda for education and training holds out some serious worries-as well as opportuni­ ties-for people and educators.
Chemical Disinfection of Creutzfeldt–Jakob Disease Virus (1982)

RECOMMENDATIONS for the disinfection of virus-contaminated tissues from patients with Creutzfeldt–Jakob disease (CJD), published five years ago in the Journal, 1 relied heavily on data from experiments using mouse-adapted scrapie virus — at that time a more conveniently studied member of the same group of spongiform encephalopathy viruses. We have now accumulated sufficient data on guinea-pig and mouse-adapted viral isolates from two patients with CJD to be able to present current recommendations based on studies of the CJD virus itself. Autoclaving for one hour at a temperature of at least 121°C (15 psi) remains the method of choice for the sterilization . . .
Preparation and biological activity of potential inhibitors of insect juvenile hormone biosynthesis (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and biological activity of potential inhibitors of insect juvenile hormone biosynthesisGary B. Quistad, Luana E. Staiger, and David C. CerfCite this: J. Agric. Food Chem. 1982, 30, 6, 1151–1154Publication Date (Print):November 1, 1982Publication History Published online1 May 2002Published inissue 1 November 1982https://pubs.acs.org/doi/10.1021/jf00114a037https://doi.org/10.1021/jf00114a037research-articleACS PublicationsRequest reuse permissionsArticle Views166Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts