gebhart/patrepeval huggingface dataset:
The clinical spectrum of Fontan-associated liver disease: results from a prospective multimodality screening cohort (2018)

The FALD spectrum includes both hepatic congestion and severe fibrosis, with signs of portal hypertension and hyperenhancing nodules as significant manifestations. Routine imaging, transient elastography, and serum biomarkers are unable to accurately assess severity of liver fibrosis in this cohort. Future research should focus on validating new diagnostic tools with biopsy as the reference standard.
Bond dissociation energies of H2NX compounds: comparison with CH3X, HOX, and FX compounds (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBond dissociation energies of H2NX compounds: comparison with CH3X, HOX, and FX compoundsKenneth B. WibergCite this: J. Phys. Chem. 1992, 96, 14, 5800–5803Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/j100193a028https://doi.org/10.1021/j100193a028research-articleACS PublicationsRequest reuse permissionsArticle Views156Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
O. Weinberger: Der Relativierungsgrundsatz und der Reduktionsgrundsatz - Zwei Prinzipien des dialektischen Denkens (1966)

Article O. Weinberger: Der Relativierungsgrundsatz und der Reduktionsgrundsatz - Zwei Prinzipien des dialektischen Denkens was published on March 1, 1966 in the journal Deutsche Zeitschrift für Philosophie (volume 14, issue 3).
Road Extraction and Topographic Data Validation Using Area Topology (1994)

A simpler novel process for extracting roads is outlined in this paper. The procedures which were adopted for checking the consistency of semantic labelling is described. And it discusses the extent to which findings should influence the database model and concludes by summarizing the findings.
Mechanism of a "jumping off" ferricenium in glucose oxidase-D-glucose-ferrocene micellar electrochemical systems (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of a "jumping off" ferricenium in glucose oxidase-D-glucose-ferrocene micellar electrochemical systemsAlexander D. Ryabov, ANton Amon, Raisa K. Gorbatova, Ekaterina S. Ryabova, and Boris B. GnedenkoCite this: J. Phys. Chem. 1995, 99, 38, 14072–14077Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/j100038a044https://doi.org/10.1021/j100038a044research-articleACS PublicationsRequest reuse permissionsArticle Views229Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Cow Body Shape and Automation of Condition Scoring (2008)

The feasibility of including a body shape measure in methods for automatic monitoring of body reserves of cattle was evaluated. The hypothesis tested was that the body shape of a fatter cow is rounder than that of a thin cow and, therefore, may better fit a parabolic shape. An image-processing model was designed that calculates a parameter to assess body shape. The model was implemented, and its outputs were validated against ultrasonic and thermal camera measurements of the thickness of fat and muscle layers, and manual body condition scoring of 186 Holstein-Friesian cows. The thermal camera overcomes some of the drawbacks of a regular camera; the hooks and the tailhead nadirs of a thin cow diverged from the parabolic shape. The correlation between thermal camera's measurements and fat and muscle thickness was 0.47. Mean body condition scorings were 2.18, 2.15, and 2.23, with no significant difference found across the assessment methods. Further research is needed to achieve fully automatic, accurate body condition scoring.
Development and Assessment of Enzyme Immunoassay for Platelet-derived Microparticles (2001)

Platelet-derived microparticles (PMPs) are released from platelets through the platelet activation by high shear stress, collagen, or calcium ionophore (A23187). PMPs are observed in patients with acute myocardial infarction, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, heparin-induced thrombocytopenia and other thrombotic disorders, but the importance of circulating PMPs in the pathogenesis of these diseases is still debated. Numbers of PMPs are usually determined by flowcytometry (FCM), but easier and reproducible PMP assay systems are needed. To develop a better ELISA for PMPs, we used antibodies against the platelet antigens anti-GPIb (NNKY5-5), anti-GPIIb/IIIa (NNKY2-11, anti-CD41), anti-GPIX (KMP-9), and anti-CD9 (NNKY1-19). PMPs were detected with all combinations of these antibodies, but the ELISA having the highest and most specific absorbance was obtained with a combination of KMP-9 (capture antibody) and NNKY5-5 (detecting antibody). PMPs in blood samples were measured by ELISA and FCM. ELISA correlated with PMPs quantitated by FCM. By shaking ELISA plates during incubation, nonspecific binding of platelets was eliminated. The level of PMPs was not increased in diabetes mellitus, thrombotic thrombocytopenic purpura, antiphospholipid syndrome, or sepsis. The concentration of PMP was elevated in hemolytic uremic syndrome. Activated PMPs were absorbed to 0.8 microm filter, but circulating PMPs were not absorbed. These results suggest that activated PMPs are likely to adhere to leukocytes or endothelial cells at the activation site and that the circulating form of PMPs are likely to be a residue of activated PMPs. To detect only the activated form of PMPs, a new ELISA needs to be developed, and it will likely use a combination of antibodies that detect platelet activation markers such as P-selectin (CD62P) or activated GPIIb/IIIa.
Impact of Phase Noise and Compensation Techniques in Coherent Optical Systems (2011)

One of the most severe impairments that affect coherent optical systems employing high-order modulation formats is phase noise due to transmit and receive lasers. This is especially detrimental in uncompensated links, where an ideal compensator for channel distortions and laser phase noise should first eliminate receive phase noise, then equalize channel distortions, and only later compensate for transmit phase noise. Unfortunately, the simultaneous presence of transmit and receive phase noise makes very difficult to discriminate between them, even in the presence of a pilot tone. Moreover, the picture is different for optical systems using single-carrier or orthogonal frequency division multiplexing, where transmit and receive phase noise components may have a different impact. All these aspects are analyzed and discussed in this paper. A novel digital coherence enhancement (DCE) technique, able to significantly reduce the phase noise of transmit or receive lasers by using an interferometric device plus a very simple electronic processing, is also described. The performance of this technique and the statistical properties of the residual phase noise are analytically derived and verified by simulations, showing a high increase of the maximum bit-rate-distance product. The practical implementation of DCE is finally discussed and some alternative implementation schemes are presented.
Effect of Combination of Anticancer Agents and Nitroimidazoles on the Survival of Human Hepatocellular Carcinoma Cells under Hypoxic Conditions (2009)

Purpose: In a previous study, we have shown that anticancer agents inhibiting topoisomerases improve survival of tumor cells under hypoxic condition. In the present study, we evaluated whether and how cell survival effect of the anticancer agents under hypoxic conditions could be eliminated by the addition of nitroimidazoles, a class of bioreductive agents. Methods: Human hepatocellular carcinoma cells (HepG2) were incubated with different combinations of pimonidazole(1∼1,000μg/ml) and doxorubicin (0.1 or 1μg/ml) concentrations under different O₂ concentrations [1, 3, 5, 10 and 21 O₂]. Then cell numbers, glucose concentrations and lactic acid concentrations in the medium were measured, and DNA fragmentation assay was performed. Finally, different combinations of nitroimidazoles, such as pimonidazole, misonidazole, etanidazole, tinidazole, metronidazole, ornidazole or dimetridazole, and anticancer agents, such as doxorubicin, campothecin, epirubicin, dactinomycin, etoposide or mitomycin C was added to the cell culture medium under hypoxic conditions (1% O₂). Results: Pimonidazole at a concentration of 100μg/ml eliminated cell survival effect of doxorubicin at the concentrations of 0.1 and 1μg/ml under hypoxic condition (1% O₂) by promoting apoptosis. Almost all the cells died even after 24 hours of incubation for all the oxygen concentrations at a combination of 100μg/ml pimonidazole and 1μg/ml doxorubicin. Finally, pimonidazole at a concentration of 100μg/ml, and misonidazole or etanidazole at a concentration of 1,000μg/ml eliminated cell survival effect of all the anticancer agents tested under hypoxic condition. Conclusion: Combination therapy of doxorubicin (adriamycin) with pimonidazole can maximize dororubicin efficacy by eliminating cell survival effect of doxorubicin under hypoxic conditions in treating solid tumors, such as breast cancer.
Development of 0.5 and 0.65 mm pitch QFP technology in surface mounting (2002)

Results from a series of experimental studies on the effect of assembly process conditions and design rules on solder joint quality for 0,5 and 0,65 mm pitch surface mounted devices are summarized. A four-layer 200 /spl times/ 300 mm/sup 2/ test board is used for experimental purposes. The main objective of the work is to optimize design and manufacturing conditions for 0.5 mm pitch quad flatpack (QFP) components. A large number of design and process parameters are studied using factorial analysis. The parameters studied are pad width, lead inplanarity and lead sweep of component, placement position, squeegee speed and squeegee angle, number of strokes and surrounding temperature. It is found that at optimum design and process conditions, zero defect failure rate can be obtained for the 0.65 mm pitch components, while for the 0.5 mm pitch component, 400 ppm in solder joint failure rate can be obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Role of nitric oxide in the maintenance of pluripotency and regulation of the hypoxia response in stem cells (2015)

Stem cell pluripotency and differentiation are global processes regulated by several pathways that have been studied intensively over recent years. Nitric oxide (NO) is an important molecule that affects gene expression at the level of transcription and translation and regulates cell survival and proliferation in diverse cell types. In embryonic stem cells NO has a dual role, controlling differentiation and survival, but the molecular mechanisms by which it modulates these functions are not completely defined. NO is a physiological regulator of cell respiration through the inhibition of cytochrome c oxidase. Many researchers have been examining the role that NO plays in other aspects of metabolism such as the cellular bioenergetics state, the hypoxia response and the relationship of these areas to stem cell stemness.
An innovative method to anchor mandibular overdenture by OT Cap semiprecision attachment: A clinical report (2012)

Since the establishment of implant in dentistry, the use of removable prostheses in replacing missing teeth apparently becomes less popular, still the preventive prosthodontics emphasizes the importance of any procedure that can delay or eliminate future prosthodontic problems. Most patients with removable partial or complete denture are dissatisfied with their retention and stability. Semiprecision attachments offer considerable advantages such as increased retention of a denture, preservation of teeth which are otherwise indicated for extraction, as a viable alternative to implant retained overdenture and the ability to obtain parallelism in divergent abutments. A prosthodontist who familiarizes himself with semiprecision attachments will be in a position to suggest a better treatment options in retaining teeth which might otherwise be considered for extraction or immediate implant placement. However, lack of proper knowledge, overwhelming number of attachments available in the market, multiple adjustments and repairs are making dentist reluctant to offer and provide attachment-retained prostheses to their patients. This case report describes an innovative technique for improving overall prognosis of mandibular overdenture using advanced and prefabricated housing attachment system.
QoS enabled voice support in the next generation Internet: issues, existing approaches and challenges (2000)

The Internet is under rapid growth and continuous evolution in order to accommodate an increasingly large number of applications with diverse service requirements. In particular, Internet telephony, or voice over IP is one of the most promising services currently being deployed. Besides the potentially significant cost reduction, Internet telephony can offer many new features and easier integration with widely adopted Web-based services. Despite these advantages, there still exist a number of barriers to the widespread deployment of Internet telephony. The most prominent one, however, is how to ensure the QoS needed for voice conversation. The purpose of this article is to survey the state-of-the-art technologies in enabling the QoS support for voice communications in the next-generation Internet. In this article, we first review the existing technologies in supporting voice over IP networks, including the basic mechanisms in the IETF Internet telephony architecture and ITU-T H.323-related Recommendations. We then discuss the IETF QoS framework, specifically the Intserv and Diffserv framework. Finally, we present two leading companies' (Cisco and Lucent) solutions to offering IP telephony services as examples to illustrate how real systems are implemented.
Optimization of joined-wing aircraft (1993)

The joined wing is an innovative aircraft configuration with a rear wing that has its root attached near the top of the vertical tail and a tip that sweeps forward to join the trailing edge of the main wing. This study demonstrates the application of numerical optimization to aircraft design and presents a quantitative comparison of joined-wing and conventional aircraft designed for the same medium-range transport mission. The computer program developed for this study used a vortex-lattice model of the complete aircraft to estimate aerodynamic performance, and a beam model of the lifting-surface structure to calculate wing and tail weight. Weight estimation depended on a fully stressed design algorithm that included a constraint on buckling and a correlation with a statistically based method for total lifting-surface weight. A variety of joined-wing and conventional aircraft designs are compared on the basis of direct operating cost, gross weight, and cruise drag. Maximum lift and horizontal tail buckling were identified as critical joined-wing design issues. The addition of a buckling constraint is shown to decrease the optimum joined-wing span and increase direct operating cost by about 4%. The most promising joined-wing designs were found to have a joint location at about 70% of the wing semispan, a fuel tank in the tail to trim, and a flap spanning 70% of the wing. These designs are shown to cost 3% more to operate than a conventional configuration designed for the same medium-range mission.
Evaluating text visualization: An experiment in authorship analysis (2013)

Analyzing authorship of online texts is an important analysis task in security-related areas such as cybercrime investigation and counter-terrorism, and in any field of endeavor in which authorship may be uncertain or obfuscated. This paper presents an automated approach for authorship analysis using machine learning methods, a robust stylometric feature set, and a series of visualizations designed to facilitate analysis at the feature, author, and message levels. A testbed consisting of 506,554 forum messages, in English and Arabic, from 14,901 authors was first constructed. A prototype portal system was then developed to support feasibility analysis of the approach. A preliminary evaluation to assess the efficacy of the text visualizations was conducted. The evaluation showed that task performance with the visualization functions was more accurate and more efficient than task performance without the visualizations.
Organizing Axes in Time and Space; 25 Years of Colinear Tinkering (2003)

During vertebrate development, clustered genes from the Hox family of transcription factors are activated in a precise temporal and spatial sequence that follows their chromosomal order (the "Hox clock"). Recent advances in the knowledge of the underlying mechanisms reveal that the embryo uses a variety of strategies to implement this colinear process, depending on both the type and the evolutionary history of axial structures. The search for a universal mechanism has likely hampered our understanding of this enigmatic phenomenon, which may be caused by various and unrelated regulatory processes, as long as the final distribution of proteins (the HOX code) is preserved.
A Study on the Mortality and Complication Rates Following Percutaneously Adjustable Pulmonary Artery Banding (2014)

The technique of percutaneously adjustable PA banding is simple and inexpensive and allows easy band adjustments without the need for multiple reoperations. Moreover, our assessment reveals that created gradient is constant and did not decrease with time.
cAMP‐regulated guanine nucleotide exchange factor II (Epac2) mediates Ca<sup>2+</sup>‐induced Ca<sup>2+</sup> release in INS‐1 pancreatic β‐cells (2001)

1. The signal transduction pathway responsible for cAMP-dependent Ca2+-induced Ca2+ release (CICR) from endoplasmic reticulum Ca2+ stores was assessed in the insulin-secreting cell line INS-1. 2. CICR was triggered by the GLP-1 receptor agonist exendin-4, an effect mimicked by caffeine, Sp-cAMPS or forskolin. CICR required influx of Ca2+ through L-type voltage-dependent Ca2+ channels, and was blocked by treatment with nimodipine, thapsigargin, or ryanodine, but not by the IP3 receptor antagonist xestospongin C. 3. Treatment with the cAMP antagonist 8-Br-Rp-cAMPS blocked CICR in response to exendin-4, whereas the PKA inhibitor H-89 was ineffective when tested at a concentration demonstrated to inhibit PKA-dependent gene expression. 4. RT-PCR of INS-1 cells demonstrated expression of mRNA coding for the type-II isoform of cAMP-regulated guanine nucleotide exchange factor (cAMP-GEF-II, Epac2). 5. CICR in response to forskolin was blocked by transient transfection and expression of a dominant negative mutant isoform of cAMP-GEF-II in which inactivating mutations were introduced into the exchange factor's two cAMP-binding domains. 6. It is concluded that CICR in INS-1 cells results from GLP-1 receptor-mediated sensitization of the intracellular Ca2+ release mechanism, a signal transduction pathway independent of PKA, but which requires cAMP-GEF-II.
Direct manipulation video navigation on touch screens (2014)

Direct Manipulation Video Navigation (DMVN) systems allow a user to directly drag an object of interest along its motion trajectory and have been shown effective for space-centric video browsing tasks. This paper designs touch-based interface techniques to support DMVN on touchscreen devices. While touch screens can suit DMVN systems naturally and enhance the directness during video navigation, the fat finger problems, such as precise selection and occlusion handling, must be properly addressed. In this paper, we discuss the effect of the fat finger problems on DMVN and develop three touch-based object dragging techniques for DMVN on touch screens, namely Offset Drag, Window Drag, and Drag Anywhere. We conduct user studies to evaluate our techniques as well as two baseline solutions on a smartphone and a desktop touch screen. Our studies show that two of our techniques can support DMVN on touch screen devices well and perform better than the baseline solutions.
Plasmid-determined resistance to tellurium compounds (1977)

Transferable plasmids in gram-negative bacteria that confer resistance to potassium tellurite or tellurate were found. This re-istance was distinct from resistance to mercury, silver, or arsenic compounds and was unrelated to antibiotic resistance. In Escherichia coli, plasmids determine a 100-fold increase in the minimal inhibitory concentration for tellurite and a 10-fold increase in tellurate resistance. Many, but not all, of the plasmids belong to incompatibility group S. In Pseudomonas aeruginosa, tellurium resistance is specifically associated with incompatibility group P-2 and involves a 5- to 10-fold increase in tellurite or tellurate resistance.