gebhart/patrepeval huggingface dataset:
T3 Directly Stimulates Basal and Modulates LH Induced Testosterone and Oestradiol Production by Rat Leydig Cells in vitro. (2000)

The effect of T3 on basal and LH mediated synthesis and secretion of testosterone and oestradiol by puberal rat Leydig cells was studied in vitro. Percoll gradient purified Leydig cells (1 x 10(3)) were cultured for 48 hours at 34 degrees C in a medium containing a range of 5-400 ng/mL concentration of T3 or ovine LH after 24 hours initial culture at 37 degrees C. T3 increased testosterone and oestradiol secretions in a dose dependent manner which reached the saturation point with 50 ng dose. While the minimum effective dose of T3 (25 ng) potentiated the stimulatory effect of the minimum effective dose of LH (25 ng) on testosterone secretion, it suppressed the effect of the saturation dose of LH (100 ng). Fifty ng T3 quelled the stimulatory effect of either dose of LH. Both doses of T3 increased oestradiol secretion, irrespective of the dose of LH. Addition of androstenedione (500 ng/mL) to the culture medium enhanced 25 ng T3 induced testosterone and oestradiol secretions. While androstenedione potentiated the stimulatory effect of T3 (25 ng) on LH (25 ng) induced testosterone and oestradiol secretions, it reversed the inhibitory effect of 50 ng T3 on LH mediated testosterone secretion which was accompanied by a decrease in oestradiol secretion. Puromycin (35 microg/mL) suppressed the stimulatory effect of T3 on basal and LH mediated testosterone and oestradiol production. Taken together, the present results indicate a direct stimulatory effects of T3 on basal production of testosterone and oestradiol by Leydig cells and its modulatory effect on LH mediated steroidogenic activity varies depending upon the intensity of LH stimuli.
Universal variable-to-fixed length source codes (2001)

A universal variable-to-fixed length algorithm for binary memoryless sources which converges to the entropy of the source at the optimal rate is known. We study the problem of universal variable-to-fixed length coding for the class of Markov sources with finite alphabets. We give an upper bound on the performance of the code for large dictionary sizes and show that the code is optimal in the sense that no codes exist that have better asymptotic performance. The optimal redundancy is shown to be H log log M/log M where H is the entropy rate of the source and M is the code size. This result is analogous to Rissanen's (1984) result for fixed-to-variable length codes. We investigate the performance of a variable-to-fixed coding method which does not need to store the dictionaries, either at the coder or the decoder. We also consider the performance of both these source codes on individual sequences. For individual sequences we bound the performance in terms of the best code length achievable by a class of coders. All the codes that we consider are prefix-free and complete.
Taking the Pulse of Molecular Rotational Spectroscopy (2011)

New methods in molecular rotational spectroscopy will characterize more complex samples and create chemical images of interstellar objects.
The Defense Switched Network and the Defense Data Network - Systems of our Time (1983)

The Defense Switched Network (DSN) and the Defense Data Network (DDN), subsystems of the Defense Communications System (DCS), are affected by changes in today's telecommunications industry. In this paper, changes in the regulatory environment and the impacts of modern technology on these systems are assessed. The demise of TELPAK, the AT&T divestiture and deregulation, and the Computer Inquiry II decision are helping to mold the DCS. The effects of these federally controlled adjustments on the telecommunications industry and the consequent impact on the DSN and the DDN are discussed. Technological changes, such as digital transmission, digital switching, common channel signaling, and modern computer use constitute segments of the complex DCS framework. These changing telecommunications technologies, and their impact on the DCS are also addressed.
Effects of thermomechanical history on hardness of aluminium (1987)

A viscoplastic constitutive model with an evolving internal state variable, called hardness, has been developed for commercially pure aluminium. One application of such a constitutive model is in process modelling where hardness distributions may be predicted throughout the workpiece. This paper assesses the accuracy with which microhardness measurements of quenched specimens correlate with the hardness predicted by the constitutive model for various imposed thermomechanical histories. Using axisymmetric compression, different hardness values are achieved by various tests, both underdeveloped (increasing hardness) and overdeveloped (decreasing hardness) structures being produced during deformation. The steady state flow stress and hardness for a particular strain rate and temperature may be achieved with less strain by first deforming at a high strain rate and then decreasing the strain rate. The constitutive model accurately predicts the amount of prestrain required at the higher strain rate. Differing initial structures are achieved by using as-extruded and fully recrystallized materials. Using microhardness measurements as a method of characterizing the initial structure, the constitutive model is able to predict the subsequent flow curve and evolution of microhardness.MST/572
DISP: Practical, Efficient, Secure, and Fault Tolerant Data Storage for Distributed Systems (2003)

We present DISP, a practical, efficient and secure client/server protocol for data storage and retrieval in a distributed environment and show how this protocol can tolerate Byzantine failure. We discuss variations on DISP that can be used as building blocks for different applications, and measure the performance of DISP on commodity hardware.
Action-oriented sensor data integration and its application to control of an autonomous vehicle (2002)

We describe the control system structure of our test autonomous vehicle for indoor movement. The control system consists of several independent "sub-controllers". Each sub-controller has its own map and planner and is tuned for one particular environment. As the vehicle moves around and encounters a different environment, a different sub-controller becomes active and plans vehicle's action. The data processing in a sub-controller becomes simple, as it copes only with one particular kind of environment. This approach enables the machine to cope with various environments by adding different sub-controllers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Extensive remyelination of the CNS leads to functional recovery (2009)

Remyelination of the CNS in multiple sclerosis is thought to be important to restore conduction and protect axons against degeneration. Yet the role that remyelination plays in clinical recovery of function remains unproven. Here, we show that cats fed an irradiated diet during gestation developed a severe neurologic disease resulting from extensive myelin vacuolation and subsequent demyelination. Despite the severe myelin degeneration, axons remained essentially intact. There was a prompt endogenous response by cells of the oligodendrocyte lineage to the demyelination, with remyelination occurring simultaneously. Cats that were returned to a normal diet recovered slowly so that by 3-4 months they were neurologically normal. Histological examination of the CNS at this point showed extensive remyelination that was especially notable in the optic nerve where almost the entire nerve was remyelinated. Biochemical analysis of the diet and tissues from affected cats showed no dietary deficiencies or toxic accumulations. Thus, although the etiology of this remarkable disease remains unknown, it shows unequivocally that where axons are preserved remyelination is the default pathway in the CNS in nonimmune-mediated demyelinating disease. Most importantly, it confirms the clinical relevance of remyelination and its ability to restore function.
Document processing for automatic knowledge acquisition (1994)

The knowledge acquisition bottleneck has become the major impediment to the development and application of effective information systems. To remove this bottleneck, new document processing techniques must be introduced to automatically acquire knowledge from various types of documents. By presenting a survey on the techniques and problems involved, this paper aims at serving as a catalyst to stimulate research in automatic knowledge acquisition through document processing. In this study, a document is considered to have two structures: geometric structure and logical structure. These play a key role in the process of the knowledge acquisition, which can be viewed as a process of acquiring the above structures. Extracting the geometric structure from a document refers to document analysis; mapping the geometric structure into logical structure is regarded as document understanding. Both areas are described in this paper, and the basic concept of document structure and its measurement based on entropy analysis is introduced. Logical structure and geometric models are proposed. Both top-down and bottom-up approaches and their entropy analyses are presented. Different techniques are discussed with practical examples. Mapping methods, such as tree transformation, document formatting knowledge and document format description language, are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
System specification with the SpecCharts language (1992)

The SpecCharts language, which builds on VHDL to meet the unique requirements of system-level specification and design, is described. With an underlying model of behavioral hierarchy, SpecCharts modeling constructs enable designers to capture system specifications simply and precisely. SpecCharts constructs facilitate system-level design tasks by permitting high-level communication, maintaining information, and allowing design modification at an easy-to-comprehend level. The results of system-level design tasks are reflected in a modified SpecCharts, enabling the designer to evaluate the quality of each step. A detailed example demonstrates the use of SpecCharts.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Crystal structures within optical tweezers (2003)

We create microcrystal structures using holographic optical tweezers to position and hold objects in three dimensions. The structures can be scaled or rotated about arbitrary axes, or made permanent by gelling the surrounding fluid.
<b>Cross‐antigenicity of horse serum albumin with dog and cat albumins: study of three short peptides with significant inhibitory activity towards specific human IgE and IgG antibodies</b> (1996)

Horse serum albumin is present in the near vicinity of the animal, while dog and cat serum albumins are very common allergens present in house dust. Human patients clinically defined as allergic to horse could react with horse serum albumin by means of IgE or IgG antibodies. Studies regarding the specificities of these antibodies by inhibition enzyme-linked immunosorbent assay (ELISA) and depletion experiments have demonstrated that they are directed against dog serum albumin and cross-react not only with horse serum albumin but with other serum albumins from different origins. To investigate these observations further, we isolated and characterized three tryptic peptides (P1, P2 and P3) from horse serum albumin. The peptide P1 contains loops 1 and 2 of the first domain, P2 is derived from loop 4 of the second domain, and P3 contains the disulphide loop 9 of the third domain. These were able to inhibit the binding of the patients' IgE and IgG antibodies to horse albumin as well as to dog and cat serum albumins. This indicates that these peptides are involved in the observed cross-reactions. They also shared common epitopes, as revealed by human IgE antibodies. After reduction and alkylation, they totally lost their inhibitory capacity, suggesting that the intra-chain disulphide bridges, essential for the preservation of the loop structure, probably maintain their allergenic/antigenic reactivity.
Optimal Asset Allocation and The Real Option to Delay Annuitization: It’s Not Now-or-Never (2002)

The D* value in addition to the D value may be useful for evaluating the nature of diffusion and flowing spins in hepatic lesions and hepatic parenchyma.
Three-colour confocal microscopy with improved colocalization capability and cross-talk suppression (1996)

A confocal microscope set-up has been modified so that three different fluorescent markers can be studied. The three fluorophores (FITC, Texas Red and Cy5) are detected at the same time, i.e. simultaneous scanning is employed. We have shown that simultaneous scanning optimizes the precise overlay of the three colour components of an image (in contrast with sequential scanning where shifts between the colour components may occur). To suppress optical cross-talk between the three fluorophores, intensity-modulated multiple-beam scanning, IMS, has been employed. Cross-talk between the fluorescence signals has been measured. Results show that cross-talk is virtually eliminated by using the IMS technique. Measurements have been performed on a triple-stained immunofluorescence specimen in order to show the applicability of the technique in biological research. Results are presented that show that the technique presented here improves the accuracy of colocalization, position and intensity measurements for studies on stationary as well as on dynamic structures.
CRM: Configurable Range Memory for Fast Reconfigurable Computing (2011)

Application-specific hardware and reconfigurable processors can dramatically speed up compute-intensive kernels of applications, offloading the burden of main processor. To minimize the communication overhead in such a coprocessor approach, the two processors can share an on-chip memory, which may be considered by each processor as a scratchpad memory. However, this setup poses a significant challenge to the main processor, which now must manage data on the scratchpad explicitly, often resulting in superfluous data copy. This paper presents an enhancement to scratchpad, called Configurable Range Memory (CRM), that can reduce the need for explicit management and thus reduce data copy and promote data reuse on the shared memory. Our experimental results using benchmarks from DSP and multimedia applications demonstrate that our CRM architecture can significantly reduce the communication overhead compared to the architecture without shared memory, while not requiring explicit data management.
Characterization of Choline Dehydrogenase from<i>Pseudomonas aeruginosa</i>A-16 (1976)

Journal Article Characterization of Choline Dehydrogenase from Pseudomonas aeruginosa A-16 Get access Toru Nagasawa, Toru Nagasawa Department of Agricultural Chemistry, Kyoto University, Kyoto Search for other works by this author on: Oxford Academic Google Scholar Nobuhiro Mori, Nobuhiro Mori Department of Agricultural Chemistry, Kyoto University, Kyoto Search for other works by this author on: Oxford Academic Google Scholar Yoshiki Tani, Yoshiki Tani Department of Agricultural Chemistry, Kyoto University, Kyoto Search for other works by this author on: Oxford Academic Google Scholar Koichi Ogata Koichi Ogata Department of Agricultural Chemistry, Kyoto University, Kyoto Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 40, Issue 10, 1 October 1976, Pages 2077–2084, https://doi.org/10.1080/00021369.1976.10862351 Published: 01 October 1976 Article history Received: 11 June 1976 Published: 01 October 1976
Cloning and functional characterization of the 5′-flanking region of the human bone morphogenetic protein-2 gene (1999)

Bone morphogenetic protein-2 (BMP-2) is involved in bone formation, organogenesis or pattern formation during development. The expression of BMP-2 is regulated accurately and coordinately with that of other transforming growth factor-beta (TGF-beta) superfamily members. To elucidate the mechanism underlying the regulation of BMP-2 expression, a 6.7 kb SpeI-SalI fragment, from the P1 phage library, encompassing the 5'-flanking region of the human BMP-2 gene, was isolated and sequenced. Transcription start sites were mapped by the 5'-rapid amplification of cDNA ends (RACE) method. It has been found that the human BMP-2 gene contains, largely, two promoter regions surrounded by GC-rich sequences with several Sp1 consensus motifs. The proximal promoter possesses a single start site, whereas several start sites are clustered in the distal promoter region. Neither TATA nor CAAT consensus sequences are found in the proximity of the start sites for either promoter. Interestingly, in no case is the transcription-initiation site common between the human and mouse BMP-2 genes, although the sequence of the BMP-2 gene is well conserved in the promoter region between two species. Transient transfection experiments with the reporter fused with various lengths of the BMP-2 promoter sequence demonstrated that there exist enhancer elements in an 1.1 kb GC-rich fragment covering both promoter regions. It is noteworthy that the enhancer elements are 5'-flanked by a 790 bp strong repressor element that is characterized by numerous AT stretches. This intriguing organization may be amenable to the tight control of the expression of BMP-2 that is essential for development or bone morphogenesis.
A Genomic Background Based Method for Association Analysis in Related Individuals (2007)

Through simulations we show that MG approach maintains high power across a range of heritabilities and possible pedigree structures, and always outperforms other contemporary methods. We also show that the power of our proposed GRAMMAR-GC approaches to that of the 'gold standard' MG for all models and pedigrees studied. We show that this method is both feasible and powerful and has correct type 1 error in the context of genome-wide association analysis in related individuals.
A precision curvature-compensated CMOS bandgap reference (1983)

This paper will discuss a precision curvature-compensated switched-capacitor CMOS bandgap reference. A monolithic prototype has exhibited average temperature drifts of 13.1 and 25.6ppm/° C over the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0-70°</tex> C and -58°C to 125° C ranges, respectively. A straight-forward room temperature trim procedure is employed.
ChemInform Abstract: REACTION PROCESS OF TITANIUM TETRACHLORIDE WITH AMMONIA IN THE VAPOR PHASE AND PROPERTIES OF THE TITANIUM NITRIDE FORMED (1983)

Abstract Gasförmiges TiCl 4 reagiert mit NH 3 bei 200°C zu TiCl 4 ‐ 5 NH 3 , das oberhalb ca. 220°C zu TiClN zersetzt wird.
Intersymbol interference due to linear and nonlinear distortion (1996)

The paper provides a recursion model for the calculation of the probability density function (pdf) of intersymbol interference (ISI) which is caused by the combined effect of linear channel dispersion and of nonlinear distortion. The nonlinearity introduces statistical interdependencies between the interfering symbols and these dependencies are implicitly taken into account in a trellis-structured recursion rule. The results were verified by time consuming Monte Carlo simulation and show, e.g., that the nonlinear characteristic of a high power amplifier (HPA) reduces in some cases the error probability caused by the linear dispersion. Surprisingly, the ISI due to the nonlinear amplifier is increased in the case of offset modulation.
Benzothiazolines as antituberculous agents (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBenzothiazolines as antituberculous agentsP. J. Palmer, R. B. Trigg, and J. V. WarringtonCite this: J. Med. Chem. 1971, 14, 3, 248–251Publication Date (Print):March 1, 1971Publication History Published online1 May 2002Published inissue 1 March 1971https://doi.org/10.1021/jm00285a022RIGHTS & PERMISSIONSArticle Views583Altmetric-Citations155LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (540 KB) Get e-Alerts Get e-Alerts
Smart multi-task scheduling for OpenCL programs on CPU/GPU heterogeneous platforms (2014)

Heterogeneous systems consisting of multiple CPUs and GPUs are increasingly attractive as platforms for high performance computing. Such platforms are usually programmed using OpenCL which provides program portability by allowing the same program to execute on different types of device. As such systems become more mainstream, they will move from application dedicated devices to platforms that need to support multiple concurrent user applications. Here there is a need to determine when and where to map different applications so as to best utilize the available heterogeneous hardware resources. In this paper, we present an efficient OpenCL task scheduling scheme which schedules multiple kernels from multiple programs on CPU/GPU heterogeneous platforms. It does this by determining at runtime which kernels are likely to best utilize a device. We show that speedup is a good scheduling priority function and develop a novel model that predicts a kernel's speedup based on its static code structure. Our scheduler uses this prediction and runtime input data size to prioritize and schedule tasks. This technique is applied to a large set of concurrent OpenCL kernels. We evaluated our approach for system throughput and average turn-around time against competitive techniques on two different platforms: a Core i7/Nvidia GTX590 and a Core i7/AMD Tahiti 7970 platforms. For system throughput, we achieve, on average, a 1.21x and 1.25x improvement over the best competitors on the NVIDIA and AMD platforms respectively. Our approach reduces the turnaround time, on average, by at least 1.5x and 1.2x on the NVIDIA and AMD platforms respectively, when compared to alternative approaches.