gebhart/patrepeval huggingface dataset:
Electronic liquid-in-glass thermometer (1976)

This project developed a device for measuring temperature in which the heat expansion of mercury is measured capacitively. Using this method, the step-like movement of the mercury restricting the performance of conventional mercury-in-glass thermometers can be reduced. In our new devices, the average step is less than 1 mK. The instability of the electronic part with time appears to limit the measuring range to 3–4 decades. The device is particularly suitable for highly accurate remote measurement of temperature. Compared with other accurate electronic devices for measuring temperature, the device constructed is extremely inexpensive.
Neoadjuvant Chemotherapy with FOLFOX4 Regimen to Treat Advanced Gastric Cancer Improves Survival without Increasing Adverse Events: A Retrospective Cohort Study from a Chinese Center (2014)

The FOLFOX4 neoadjuvant chemotherapy could improve survival without increasing adverse events in patients with AGC.
HIV Infects Bronchial Epithelium and Suppresses Components of the Mucociliary Clearance Apparatus (2017)

Recurrent lung infections and pneumonia are emerging as significant comorbidities in the HIV-infected population in the era of combination antiretroviral therapy (cART). HIV infection has been reported to suppress nasal mucociliary clearance (MCC). Since the primary components driving nasal MCC and bronchial MCC are identical, it is possible that bronchial MCC is affected as well. Effective MCC requires optimal ciliary beating which depends on the maintenance of the airway surface liquid (ASL), a function of cystic fibrosis transmembrane conductance regulator (CFTR) activity and the integrity of the signaling mechanism that regulates ciliary beating and fluid secretion. Impairment of either component of the MCC apparatus can compromise its efficacy and promote microbial colonization. We demonstrate that primary bronchial epithelium expresses HIV receptor CD4 and co-receptors CCR5 and CXCR4 and can be infected by both R5 and X4 tropic strains of HIV. We show that HIV Tat suppresses CFTR biogenesis and function in primary bronchial epithelial cells by a pathway involving TGF-β signaling. HIV infection also interferes with bronchial epithelial cell differentiation and suppresses ciliogenesis. These findings suggest that HIV infection suppresses tracheobronchial mucociliary clearance and this may predispose HIV-infected patients to recurrent lung infections, pneumonia and chronic bronchitis.
Role of the Tuberous Sclerosis Gene-2 Product in Cell Cycle Control (1997)

Tuberous sclerosis is an autosomal dominant disorder characterized by the development of benign growths in many tissues and organs. Linkage analysis revealed two disease-determining genes on chromosome 9 and chromosome 16. The TSC2 gene on chromosome 16 encodes a 1784-amino acid tumor suppressor protein, tuberin, that functions as a GTPase-activating protein for Rap1, a member of the superfamily of Ras-related proteins. By immunoblot analyses, we found TSC2 expression to be high in G0 as well as in early small G1 cells. Analyses after different cell synchronization procedures revealed that TSC2 mRNA and protein expression do not fluctuate throughout the cell cycle. Using inducible expression systems we further demonstrated that TSC2 expression is not affected by overexpression of the mitogenic transcription factor E2F-1 or c-Myc. Nevertheless, antisense inhibition of tuberin expression in logarithmically growing cells markedly decreased the percentage of cells in G1. Furthermore, we found that cells exposed to TSC2 antisense oligonucleotides did not undergo G0 arrest after serum withdrawal. Antisense inhibition of TSC2 expression also induced quiescent G0-arrested fibroblasts to reenter the cell cycle. Our data show for the first time that the absence of tuberin can both induce cells to pass through the G1/S transition of the eukaryotic cell cycle and prevent them from entering a quiescent state. These results have clear implications for the tumor suppressor function of TSC2. We further found that reentry into the cell cycle upon loss of TSC2 is dependent on the activity of the G1 cyclin-dependent kinases (CDKs), Cdk2 or Cdk4. Taken together with our finding that antisense inhibition of TSC2 causes up-regulation of cyclin D1 expression, these results provide the first evidence for a connection between tuberin/Rap1 and the G1 CDK-dependent regulation of the transition from G0/G1 to S phase.
Time domain decoding of extended Reed-Solomon codes (2002)

Time domain decoding of extended and doubly extended Reed-Solomon codes are considered for both errors only decoding and errors and erasures decoding. The parity check and generator matrices are given for the singly and doubly extended Reed-Solomon codes in terms of the parity check and generator matrices of the Reed-Solomon codes. Syndrome calculations for the singly and doubly extended codes are discussed and the modifications necessary for the error location and error magnitude calculations are given. The modifications necessary for decoding extended Reed-Solomon codes using the Berlekamp-Massey algorithm and Euclid's algorithm for finding the error magnitudes are presented for both errors only and errors and erasures decoding.
Pharmacological Effects of .SIGMA.-Receptor Ligands. Anti-amnesic effects of sigma (.SIGMA.)-receptor agonists. (1999)

Both traditional and novel sigma (sigma)-receptor agonists have been reported to possess anti-amnesic effects in rodents. In particular, the anti-amnesic effects induced by the novel sigma1-receptor agonists, such as (+)-pentazocine, SA4503 and PRE-084, were shown in beta amyloid-peptide-induced, basal forebrain (BF)-lesioned and carbon monoxide (CO)-induced amnesia models and senescence-accelerated mouse (SAM). In addition, these sigma1-receptor agonists have good profiles for the central acetylcholine and dopamine systems. Moreover, they also have neuroprotective and anti-depressive effects. These evidence suggested that the sigma1-receptor agonists may be promising compounds for the treatment of dementing disorders such as Alzheimer's disease, senile dementia and vascular dementia. However, the sigma-receptor family is still considered to be enigmatic molecular targets. More molecular cloning and biochemical studies on the sigma-receptor family are needed.
Materials under strain (1984)

Report on The mechanical properties of materials at high rates of strain, The Institute of Physics and the Institution of Mechanical Engineers, sponsored by USAF (European Office), 9-12 April 1984 at the University of Oxford.
<title>Flexible multiservice ATM network interface using reconfigurable logic devices</title> (1998)

The ATM network was designed to deal with all sorts of traffic such as data-, voice-, and video-traffic. This is achieved using service categories (CBR, VBR, ABR, and UBR) and AAL protocols. Existing ATM Network Interface Cards (NICs) realize the full-range of service categories but generally perform only one AAL protocol (AAL1 $ARLR AAL5). Research in our laboratory investigates possibilities that offer reconfigurable logic (FPGA) in the field of ATM NICs. In this paper, we present a flexible multiservice ATM network interface. It is flexible through the use of FPGA (and eventually other resources like multipurpose processors) and it is multiservice as it enables lots of possible AAL-protocols, including complete AAL1 and AAL5, at one and the same time and also new specialized, proprietary adaptation protocols. These new protocols could be specially designed for security, compression, data structure recognition, ... Here present bandwidth estimations based on sample implementations and possible target architectures using different types of FPGAs (statically or partially/dynamically reconfigurable). Their advantages and drawbacks are discussed. Finally we try to isolate the open questions related to the flexible multiservice network interface.
<i>pitx3</i>defines an equivalence domain for lens and anterior pituitary placode (2005)

Hedgehog signaling is required for formation and patterning of the anterior pituitary gland. However, the role of Hedgehog in pituitary precursor cell specification and subsequent placode formation is not well understood. We analyzed pituitary precursor cell lineages and find that pitx3 and distal-less3b (dlx3b) expression domains define lens and pituitary precursor positions. We show that pitx3 is required for pituitary pre-placode formation and cell specification, whereas dlx3b and dlx4b are required to restrict pituitary placode size. In smoothened mutant embryos that cannot transduce Hedgehog signals, median pituitary precursors are mis-specified and form an ectopic lens. Moreover, overexpression of sonic hedgehog (shh) blocks lens formation, and derivatives of lens precursors express genes characteristic of pituitary cells. However, overexpression of shh does not increase median pituitary placode size nor does it upregulate patched (ptc) expression in pituitary precursors during early somitogenesis. Our study suggests that by the end of gastrulation, pitx3-expressing cells constitute an equivalence domain of cells that can form either pituitary or lens, and that a non-Hedgehog signal initially specifies this placodal field. During mid-somitogenesis, Hedgehog then acts on the established median placode as a necessary and sufficient signal to specify pituitary cell types.
Identifying redundancy in source code using fingerprints (1993)

NRC publication: Yes
WEE1 Inhibition Sensitizes Basal Breast Cancer Cells to TRAIL-Induced Apoptosis (2011)

TRAIL is a member of the TNF super family and has been shown to induce apoptosis in many cancer cell lines but not in normal cells. Breast cancers can be divided into different subgroups on the basis of the expression of estrogen and progesterone receptors, HER-2 amplification, or the lack of these three markers (known as triple-negative or basal-type breast cancer). Our group and others have shown previously that triple-negative breast cancer cell lines are sensitive to TRAIL whereas others are relatively resistant. In an earlier study, we reported that inhibition of WEE1, a cell-cycle checkpoint regulator, causes increased cell death in breast cancer cell lines. In this study, we tested the effects of WEE1 inhibition on TRAIL-mediated apoptosis in breast cancer cell lines. Pretreatment with WEE1 inhibitor or knockdown of WEE1 increased the toxicity of TRAIL in the basal/triple-negative breast cancer cell lines compared with WEE1 inhibitor or TRAIL treatment alone. The enhanced cell death is attributed to increased surface expression of death receptors, increased caspase activation which could be blocked by the pan-caspase inhibitor, Z-VAD-FMK, thereby rescuing cells from caspase-mediated apoptosis. The cell death was initiated primarily by caspase-8 because knockdown of caspase-8 and not of any other initiator caspases (i.e., caspase-2, -9, or -10) rescued cells from WEE1 inhibitor-sensitized TRAIL-induced cell death. Taken together, the data suggest that the combination of WEE1 inhibitor and TRAIL could provide a novel combination for the treatment of basal/triple-negative breast cancer.
Molecular cloning of a 10-deacetylbaccatin III-10-<i>O</i>-acetyl transferase cDNA from<i>Taxus</i>and functional expression in<i>Escherichia coli</i> (2000)

The cDNA clone for a 10-deacetylbaccatin III-10-O-acetyl transferase, which catalyzes formation of the last diterpene intermediate in the Taxol biosynthetic pathway, has been isolated from Taxus cuspidata. By using consensus sequences from an assembly of transacylases of plant origin and from many deduced proteins of unknown function, a homology-based PCR cloning strategy was employed to amplify initially a 911-bp gene fragment of the putative taxane C-10 hydroxyl acetyl transferase from Taxus. This amplicon was used to screen a cDNA library constructed from mRNA isolated from methyl jasmonate-induced Taxus cells, from which the full-length 10-deacetylbaccatin III-10-O-transacetylase sequence was obtained. Expression of the ORF from pCWori(+) in Escherichia coli JM109 afforded a functional enzyme, as determined by (1)H-NMR and MS verification of the product baccatin III derived from 10-deacetylbaccatin III and acetyl CoA. The full-length cDNA has an ORF of 1,320 bp corresponding to a deduced protein of 440 residues with a calculated molecular weight of 49,052, consistent with the size of the operationally soluble, monomeric, native acetyl transferase. The recombinant acetyl transferase has a pH optimum of 7.5, has K(m) values of 10 microM and 8 microM for 10-deacetylbaccatin III and acetyl CoA, respectively, and is apparently regiospecific toward the 10-hydroxyl group of the taxane ring. Amino acid sequence comparison of 10-deacetylbaccatin III-10-O-acetyl transferase with taxadienol-5-O-acetyl transferase and with other known acyl transferases of plant origin indicates a significant degree of similarity between these enzymes (80% and 64-67%, respectively).
A new design of a semiconductor bolometer on rigid substrate for fusion plasma diagnostics (1993)

A new, fast, and very sensitive semiconductor bolometer has been designed and developed for the measurement of radiative energy losses in fusion devices in which the hard radiation level is not too high. Special care was taken in the design of the bolometer to simplify both the construction technology and the installation in fusion devices. The major novelty of this bolometer is the use of a low thermal conductivity rigid substrate, instead of the typical thin foil stretched on a rigid frame. In spite of large detector-substrate contact area, the cooling time constant reaches values as high as 150 ms. The rigid substrate allows the detector to be very robust and reliable; moreover, the monolithic integration of array structures is straightforward. The detector has been fabricated with a thin-film multilayer technology achieving very low thermal capacitance (&lt;2 mJ/K) and very low response time (&lt;5 μs). High responsivity (20 V/W) is obtained using GeOx thin film with a high thermal coefficient of the electrical resistance (−4.5%/K) as sensing thermistor.
A convenient palladium-catalyzed aerobic oxidation of alcohols at room temperatureElectronic supplementary information (ESI) available: screening procedures and optimization tables. See http://www.rsc.org/suppdata/cc/b2/b209344h/ (2002)

A simple Pd-catalyzed aerobic oxidation of benzylic and aliphatic alcohols to the corresponding aldehydes and ketones at room temperature is described.
Tyrosinase-Based Biosensors for Selective Dopamine Detection (2017)

A novel tyrosinase-based biosensor was developed for the detection of dopamine (DA). For increased selectivity, gold electrodes were previously modified with cobalt (II)-porphyrin (CoP) film with electrocatalytic activity, to act both as an electrochemical mediator and an enzyme support, upon which the enzyme tyrosinase (Tyr) was cross-linked. Differential pulse voltammetry was used for electrochemical detection and the reduction current of dopamine-quinone was measured as a function of dopamine concentration. Our experiments demonstrated that the presence of CoP improves the selectivity of the electrode towards dopamine in the presence of ascorbic acid (AA), with a linear trend of concentration dependence in the range of 2-30 µM. By optimizing the conditioning parameters, a separation of 130 mV between the peak potentials for ascorbic acid AA and DA was obtained, allowing the selective detection of DA. The biosensor had a sensitivity of 1.22 ± 0.02 µA·cm<sup>-2</sup>·µM<sup>-1</sup> and a detection limit of 0.43 µM. Biosensor performances were tested in the presence of dopamine medication, with satisfactory results in terms of recovery (96%), and relative standard deviation values below 5%. These results confirmed the applicability of the biosensors in real samples such as human urine and blood serum.
In-Band Control for an Ethernet-Based Software-Defined Network (2014)

A distinguishing characteristic of a software-defined network is separation of the network's control plane from its data plane. Especially when the granularity of control is an individual network flow, such separation entails frequent communications between these two planes. This communication pattern demands the same level of resilience from the control plane as that from the data plane, and thus calls into question the conventional out-of-band control network design as used in many existing SDN systems. Peregrine is an Ethernet-based software-defined network that was originally designed as the internal network of a container computer, and unifies storage access, inter-server communication, and network control into a single network comprising only commodity off-the-shelf Ethernet switches. To fully utilize all available physical network links, Peregrine treats the physical network as an explicitly routed mesh and equalizes the loads of its links using a global load-balancing routing algorithm running on a centralized controller. The in-band control architecture of Peregrine leads to two issues: (1) how to evolve a Peregrine network from its initial bootstrapping mode to the explicit routing mode at run time, and (2) how to support fast fail-over for physical failures that break both the control and data plane. This paper describes how Peregrine addresses these two issues, and shows its effectiveness with performance measurements collected from a fully operational test-bed.
Target‐oriented common reflection angle migration (2002)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2002Target‐oriented common reflection angle migrationAuthors: Zvi KorenSheng XuDan KosloffZvi KorenParadigm Geophysical Ltd., Sheng XuParadigm Geophysical Ltd., and Dan KosloffTel‐Aviv Universityhttps://doi.org/10.1190/1.1816865 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1816865FiguresReferencesRelatedDetailsCited ByPre‐stack Kirchhoff depth migration local space‐shift imaging condition: synthetic and data examples5 March 2019 | Geophysical Prospecting, Vol. 67, No. 5Application of common reflection angle migration for imaging deformation structures in an inner accretionary wedge, Nankai Trough, Japan21 December 2018 | Geophysical Prospecting, Vol. 67, No. 2Investigating a time-shift extended imaging condition in a Kirchhoff pre-stack depth migration algorithm1 March 2018 | Geophysical Prospecting, Vol. 66, No. 4Improved Imaging for Fault and Fracture Characterization: Southwest Onshore Abu Dhabi Case Study12 November 2018Kirchhoff migration with a time-shift extended imaging condition: A synthetic exampleGareth O'Brien, Sean Delaney, Michael Igoe, and John Doherty17 August 2017Full-azimuth anisotropic prestack time migration in the local-angle domain and its applications on fracture detectionXuekai Sun and Sam Zandong Sun27 February 2015 | GEOPHYSICS, Vol. 80, No. 2Recent seismic technologies for sub-salt explorationJournal of the Japanese Association for Petroleum Technology, Vol. 79, No. 1Specular filter (SF) and dip oriented partial imaging (DOPI) beam migrationQie Zhang and Caroline Selwood19 August 2013Phase-space computation of multi-arrival traveltimes: Part II – Implementation and application to angle-domain imagingVladimir Bashkardin, Thomas J. Browaeys, Sergey Fomel, Fuchun Gao, Scott A. Morton, Sergey Terentyev, and Alexander Vladimirsky25 October 2012Full-azimuth subsurface angle domain wavefield decomposition and imaging: Part 2 — Local angle domainGEOPHYSICS, Vol. 76, No. 2Full-azimuth subsurface angle domain wavefield decomposition and imaging Part I: Directional and reflection image gathersGEOPHYSICS, Vol. 76, No. 1Angle‐domain seismic imaging and the oriented wave equationSergey Fomel3 January 2005 SEG Technical Program Expanded Abstracts 2002ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2002 Pages: 2478 publication data© 2002 Copyright © 2002 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 03 Jan 2005 CITATION INFORMATION Zvi Koren, Sheng Xu, and Dan Kosloff, (2002), "Target‐oriented common reflection angle migration," SEG Technical Program Expanded Abstracts : 1196-1199. https://doi.org/10.1190/1.1816865 Plain-Language Summary PDF DownloadLoading ...
Insulin produces myogenesis in C2C12 myoblasts by induction of NF-?B and downregulation of AP-1 activities (2000)

In the present study, we have examined the insulin-signaling pathways involved in myogenesis in mouse C2C12 skeletal muscle cell line, a cellular system that expresses high number of high affinity insulin receptors. Insulin (50 nM) rapidly (5 min) stimulated beta-chain insulin receptor, activated the phosphatidylinositol (PI) 3-kinase/Akt/p70S6-kinase signaling pathway, as well as phosphorylated both p44/p42- and p38-mitogen-activated protein kinases (MAPKs). Preconfluent cells were differentiated in a serum-free medium in response to 50 nM insulin for 72 h, as revealed by the formation of multinucleated myotubes and the induction of the creatine kinase activity. This differentiation process was also monitored by the inhibition of the PCNA content and induction of the cell cycle inhibitor p21. Furthermore, insulin induced nuclear factor-kappaB (NF-kappaB) DNA binding activity and down-regulated activating protein-1 (AP-1) DNA binding activity throughout the differentiation process. The use of specific inhibitors of the insulin-signaling pathways indicated that myogenesis was precluded by treatment for 72 h with LY294002 (an inhibitor of PI 3-kinase), rapamycin (a p70S6-kinase blocker), and SB203580 or PD169316 (p38-MAPK inhibitors). These inhibitors abolished insulin induction of NF-kappaB DNA binding activity and kappaB-chloramphenicol acetyltransferase (CAT) promoter activity, maintaining expressed cytosolic IkappaB-alpha protein, and increased AP-1 DNA binding activity and TRE-CAT promoter activity. These data suggest that insulin induces myogenesis in C2C12 through PI 3-kinase/ p70S6-kinase and p38-MAPK pathways, the signaling through p44/p42-MAPK being inhibited.
Induction of T-Cell Differentiation <i>In Vitro</i> by Thymin, a Purified Polypeptide Hormone of the Thymus (1974)

Thymin, a purified polypeptide isolated from bovine thymus, was shown to induce the expression of differentiation antigens characteristic of thymocytes [TL and Thy-1 (theta)] when incubated in vitro with mouse bone marrow or spleen cells. This induction occurred in 5-10% of the cells from bone marrow after a 2-hr incubation with subnanogram concentrations of thymin. The induced cells expressed more TL and Thy-1 (theta) antigens than average normal thymocytes.
P‐41: PMOLED Driver Design with Pre‐Charge Power Saving Algorithm (2006)

Abstract The PMOLED (Passive Matrix Organic Light Emitting Diode) panel size is limited due to the various reasons; increase of power consumption, degradation of display quality and so on. Suppressing the increment of pre‐charge power consumption according to the increment of panel size is one of the main power issues. The PMOLED driver IC with proposed alternative pre‐charge algorithm for saving pre‐charge power is presented in this paper. This driver IC is applied to the QCIF+(220RGB×176) panel. The pre‐charge power consumption of driver IC with proposed alternative pre‐charge method can be reduced by 50∼70% of the normal method without displays quality degradation.