gebhart/patrepeval huggingface dataset:
Role of <i>I</i> <sub>Kur</sub> in Controlling Action Potential Shape and Contractility in the Human Atrium (2004)

Whether inhibition of I(Kur) prolongs or shortens APD depends on the disease status of the atria and is determined by the level of electrical remodeling.
IR detection and characterization of (N2-1-butene)dicarbonylnitrosylcobalt and the iron complex Fe(CO)2-x(NO)2(.mu.2-1-btn)x (x = 1 or 2; 1-btn = 1-butene) in liquid xenon solution (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIR detection and characterization of (N2-1-butene)dicarbonylnitrosylcobalt and the iron complex Fe(CO)2-x(NO)2(.mu.2-1-btn)x (x = 1 or 2; 1-btn = 1-butene) in liquid xenon solutionGerard E. Gadd, Martyn Poliakoff, and James J. TurnerCite this: Inorg. Chem. 1986, 25, 20, 3604–3608Publication Date (Print):September 1, 1986Publication History Published online1 May 2002Published inissue 1 September 1986https://pubs.acs.org/doi/10.1021/ic00240a015https://doi.org/10.1021/ic00240a015research-articleACS PublicationsRequest reuse permissionsArticle Views38Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Statistical Models: Theory and Practice (2005)

This lively and engaging textbook provides the knowledge required to read empirical papers in the social and health sciences, as well as the techniques needed to build statistical models. The author explains the basic ideas of association and regression, and describes the current models that link these ideas to causality. He focuses on applications of linear models, including generalized least squares and two-stage least squares. The bootstrap is developed as a technique for estimating bias and computing standard errors. Careful attention is paid to the principles of statistical inference. There is background material on study design, bivariate regression, and matrix algebra. To develop technique, there are computer labs, with sample computer programs. The book's discussion is organized around published studies, as are the numerous exercises - many of which have answers included. Relevant papers reprinted at the back of the book are thoroughly appraised by the author.
Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells. (1992)

Plasma membranes of cultured cells contain high affinity receptors for high density lipoprotein (HDL) that appear to mediate removal of excess intracellular cholesterol. Recent studies using ligand blot analysis have identified a 110-kDa membrane protein which has features predicted for an HDL receptor, in that it preferentially binds HDL apolipoproteins and undergoes up-regulation in response to cholesterol loading of cells. In this study, we isolated a cDNA clone from an expression library using an antibody raised against partially purified 110-kDa HDL-binding protein. This clone encodes a novel cell protein, designated HBP, comprised mostly of 14 imperfect tandem repeats of approximately 70 amino acids in length. Each repeat appears to contain two amphipathic helices. Expression of HBP in cultured cells was increased severalfold when cells were loaded with cholesterol, as evident by increases in both HBP mRNA and membrane-associated protein. Overexpression of HBP in mammalian cell transfectants was associated with higher HDL binding to isolated cell protein and with modest increases in HDL binding to the cell surface. Proteins identified by ligand blot analysis had lower apparent M(r) than the primary HBP gene product and varied in M(r) and in HDL binding activity between cell types, suggesting that HBP undergoes cell-specific processing. These results provide preliminary evidence that HBP is a component of a cellular pathway that facilitates removal of excess cholesterol from cells, perhaps through its interaction with HDL. However, the predicted structure of HBP does not conform to that of any known receptor, suggesting that it does not function as a classic plasma membrane receptor.
Estimation of Liver Function Using T1 Mapping on Gd-EOB-DTPA-Enhanced Magnetic Resonance Imaging (2011)

Evaluation of hepatic uptake of Gd-EOB-DTPA using T1 mapping of liver parenchyma can help estimate liver function.
Medical 3D printing: methods to standardize terminology and report trends (2017)

Our methodology can be applied to the entirety of medical 3D printing literature to obtain a complete, validated, and objective set of recommended and synonymous definitions to aid expert bodies in building ontological consensus.
Genetic and epigenetic events in diabetic wound healing (2010)

The prevalence of the chronic metabolic disorder, diabetes mellitus, is expected to increase in the coming years and worldwide pandemic levels are predicted. Inevitably, this will be accompanied by an increase in the prevalence of diabetic complications, including diabetic foot ulcers. At present, treatment options for diabetic foot ulcers are in many cases insufficient, and progression of the condition results in the requirement for limb amputation in a proportion of patients. To improve therapy, an increase in our understanding of the pathobiology of diabetic complications such as impaired wound healing is necessary. In this review, recent advances in molecular aspects of normal and impaired diabetic wound healing are discussed. Furthermore, investigations of the role of epigenetic processes in the pathogenesis of impaired diabetic wound healing are now emerging. Indeed, epigenetic changes have already been identified as key factors in diabetes and related complications and these are overviewed in this review.
Cell Surface-Associated Lipoteichoic Acid Acts as an Adhesion Factor for Attachment of <i>Lactobacillus johnsonii</i> La1 to Human Enterocyte-Like Caco-2 Cells (1999)

The influence of pH on the adhesion of two Lactobacillus strains to Caco-2 human intestinal cells was investigated. One strain, Lactobacillus johnsonii La1, was adherent at any pH between 4 and 7. The other one, L. acidophilus La10, did not attach to this cell line under the same experimental conditions. On the basis of these results, we used the monoclonal antibody technique as a tool to determine differences on the surface of these bacteria and to identify a factor for adhesion. Mice were immunized with live La1, and the hybridomas produced by fusion of spleen cells with ONS1 cells were screened for the production of antibodies specific for L. johnsonii La1. A set of these monoclonal antibodies was directed against a nonproteinaceous component of the L. johnsonii La1 surface. It was identified as lipoteichoic acid (LTA). This molecule was isolated, chemically characterized, and tested in adhesion experiments in the same system. The adhesion of L. johnsonii La1 to Caco-2 cells was inhibited in a concentration-dependent way by purified LTA as well as by L. johnsonii La1 culture supernatant that contained LTA. These results showed that the mechanism of adhesion of L. johnsonii La1 to human Caco-2 cells involves LTA.
KSR is a scaffold required for activation of the ERK/MAPK module (2002)

Mechanisms that regulate signal propagation through the ERK/MAPK pathway are still poorly understood. Several proteins are suspected to play critical roles in this process. One of these is Kinase Suppressor of Ras (KSR), a component previously identified in RAS-dependent genetic screens in Drosophila and Caenorhabditis elegans. Here, we show that KSR functions upstream of MEK within the ERK/MAPK module. In agreement with this, we found that KSR facilitates the phosphorylation of MEK by RAF. We further show that KSR associates independently with RAF and MEK, and that these interactions lead to the formation of a RAF/MEK complex, thereby positioning RAF in close proximity to its substrate MEK. These findings suggest that KSR functions as a scaffold that assembles the RAF/MEK functional pair.
Asymmetric transformation of .alpha.-amino acids promoted by optically active cobalt(III) complexes (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric transformation of .alpha.-amino acids promoted by optically active cobalt(III) complexesM. Yamaguchi, S. Yamamatsu, T. Furusawa, S. Yano, M. Saburi, and S. YoshikawaCite this: Inorg. Chem. 1980, 19, 7, 2010–2016Publication Date (Print):July 1, 1980Publication History Published online1 May 2002Published inissue 1 July 1980https://pubs.acs.org/doi/10.1021/ic50209a035https://doi.org/10.1021/ic50209a035research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Growth Factors Stimulate Neointimal Cells In Vitro and Increase the Thickness of the Neointima Formed at the Neck of Porcine Aneurysms Treated by Embolization (2000)

PDGF-BB and TGF-beta(1) can stimulate neointimal cells in vitro and neointima formation in vivo, but TGF-beta(1) and platelet extracts do not compensate for deficient thrombosis in canine aneurysms. Effects on the long-term results of embolization remain speculative.
Self-Assembly of Supramolecular Light-Harvesting Arrays from Covalent Multi-Chromophore Perylene-3,4:9,10-bis(dicarboximide) Building Blocks (2004)

We report on two multi-chromophore building blocks that self-assemble in solution and on surfaces into supramolecular light-harvesting arrays. Each building block is based on perylene-3,4:9,10-bis(dicarboximide) (PDI) chromophores. In one building block, N-phenyl PDI chromophores are attached at their para positions to both nitrogens and the 3 and 6 carbons of pyromellitimide to form a cross-shaped molecule (PI-PDI(4)). In the second building block, N-phenyl PDI chromophores are attached at their para positions to both nitrogens and the 1 and 7 carbons of a fifth PDI to produce a saddle-shaped molecule (PDI(5)). These molecules self-assemble into partially ordered dimeric structures (PI-PDI(4))(2) and (PDI(5))(2) in toluene and 2-methyltetrahydrofuran solutions with the PDI molecules approximately parallel to one another primarily due to pi-pi interactions between adjacent PDI chromophores. On hydrophobic surfaces, PDI(5) grows into rod-shaped nanostructures of average length 130 nm as revealed by atomic force microscopy. Photoexcitation of these supramolecular dimers in solution gives direct evidence of strong pi-pi interactions between the excited PDI chromophore and other PDI molecules nearby based on the observed formation of an excimer-like state in <130 fs with a lifetime of about 20 ns. Multiple photoexcitations of the supramolecular dimers lead to fast singlet-singlet annihilation of the excimer-like state, which occurs with exciton hopping times of about 5 ps, which are comparable to those observed in photosynthetic light-harvesting proteins from green plants.
Molecular and Cellular Basis for the Anti‐Proliferative Effects of the HDAC Inhibitor LAQ824 (2004)

We have developed a cinnamic hydroxamic class of histone deacetylase inhibitors of which a prototype was designated as NVP-LAQ824. NVP-LAQ824, inhibits histone deacetylase enzymatic activities in vitro and transcriptionally activated the p21 promoter in reporter gene assays. When tested on a variety of solid tumour cell lines, NVP-LAQ824 exhibited selective anti-proliferative effects, inducing cell growth inhibition in some, while inducing cell death in others. To induce cell death, a minimum of 16 h exposure to NVP-LAQ824 is required. Flow cytometry studies revealed that both tumour cell lines and normal diploid fibroblasts arrested in the G2/M phase of the cell cycle after compound treatment. However, an increased sub-G1 population at 48 h (reminiscent of apoptotic cells) was only observed in the cancer cell lines. Annexin V staining data confirmed that NVP-LAQ824 induced apoptosis in tumour cells, but not in normal cells. To relate HDAC inhibition to the anti-proliferative effects of NVP-LAQ824, expression of HDAC 1 was inhibited using antisense and this was sufficient to activate p21 expression, hypophosphorylate Rb and inhibit cell growth. Furthermore, tumour cells treated with NVP-LAQ824 caused acetylation of HSP90 and degradation of its cargo oncoproteins. Finally, NVP-LAQ824 exhibited antitumour effects in a xenograft animal model. To determine if NVP-LAQ824 inhibited histone deacetylases in vivo, tumours treated with the drug were immunoblotted with an antibody specific for acetylated histones H3 and H4 and the results indicated increased histone H3 and 114 acetylation levels in NVP-LAQ824 treated cancer cells. Together, our data indicated that the activity of NVP-LAQ824 was consistent with its intended mechanism of action. This novel HDAC inhibitor is currently in clinical trials as an anticancer agent.
Interactive graphic design using automatic presentation knowledge (1994)

Article Interactive graphic design using automatic presentation knowledge Share on Authors: Steven F. Roth School of Computer Science, Carnegie Mellon University, Pittsburgh, PA School of Computer Science, Carnegie Mellon University, Pittsburgh, PAView Profile , John Kolojejchick School of Computer Science, Carnegie Mellon University, Pittsburgh, PA School of Computer Science, Carnegie Mellon University, Pittsburgh, PAView Profile , Joe Mattis School of Computer Science, Carnegie Mellon University, Pittsburgh, PA School of Computer Science, Carnegie Mellon University, Pittsburgh, PAView Profile , Jade Goldstein School of Computer Science, Carnegie Mellon University, Pittsburgh, PA School of Computer Science, Carnegie Mellon University, Pittsburgh, PAView Profile Authors Info & Claims CHI '94: Proceedings of the SIGCHI Conference on Human Factors in Computing SystemsApril 1994 Pages 112–117https://doi.org/10.1145/191666.191719Online:24 April 1994Publication History 59citation1,874DownloadsMetricsTotal Citations59Total Downloads1,874Last 12 Months138Last 6 weeks19 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Room-temperature formation of molecular sieve MCM-41 (1995)

K. J. Edler and J. W. White, J. Chem. Soc., Chem. Commun., 1995, 155 DOI: 10.1039/C39950000155
From frequent itemsets to semantically meaningful visual patterns (2007)

Data mining techniques that are successful in transaction and text data may not be simply applied to image data that contain high-dimensional features and have spatial structures. It is not a trivial task to discover meaningful visual patterns in image databases, because the content variations and spatial dependency in the visual data greatly challenge most existing methods. This paper presents a novel approach to coping with these difficulties for mining meaningful visual patterns. Specifically, the novelty of this work lies in the following new contributions: (1) a principled solution to the discovery of meaningful itemsets based on frequent itemset mining; (2) a self-supervised clustering scheme of the high-dimensional visual features by feeding back discovered patterns to tune the similarity measure through metric learning; and (3) a pattern summarization method that deals with the measurement noises brought by the image data. The experimental results in the real images show that our method can discover semantically meaningful patterns efficiently and effectively.
Catalytic Enantioselective Construction of All-Carbon Quaternary Stereocenters (2006)

Catalytic enantioselective construction of all-carbon quaternary stereocenters, i.e. carbon atoms bearing four different carbon substituents, poses a particular challenge in organic synthesis. This review gives a comprehensive account on the currently available methods of the above transformation that afford high enantioselectivities and synthetically useful yields.
Data Digest: Data Imagification and Application (2018)

딥 러닝과 빅데이터 기술이 발전함에 따라 대량의 원시 데이터를 전처리하여 분석을 용이하게 할 수 있는 기술들이 많은 주목을 받고 있다. 이에 본 논문에서는 이질적인 고차원 데이터를 효율적으로 전처리하고 통합하기 위한 방법으로서 데이터를 이미지의 형태로 변환하는 Data Digest 기법을 제안한다. 이 기법을 이용하면 서로 다른 종류의 데이터를 효율적으로 전처리하고 통합할 수 있으며, 이러한 이미지 데이타는 잘 알려진 딥러닝 기술에 쉽게 적용될 수 있다. 본 제안 방법의 유효성을 보이기 위한 실질적인 응용예로서 데이터 이미지화 기법을 실내외 측위 기술과 최대전력수요 예측 기법에 적용한 결과를 제시한다.
PROTEOLYTIC ACTIVITY AND GENERAL CHARACTERISTICS OF A MARINE BACTERIUM, <i>AEROMONAS PROTEOLYTICA</i> SP. N (1964)

Merkel, Joseph R. (Fort Johnson Marine Biological Laboratory, College of Charleston, Charleston, S.C.), Eugene D. Traganza, Barid B. Mukherjee, Travis B. Griffin, and J. M. Prescott. Proteolytic activity and general characteristics of a marine bacterium, Aeromonas proteolytica sp. n. J. Bacteriol. 87:1227-1233. 1964.-A highly proteolytic bacterial species was isolated from the alimentary canal of the marine borer, Limnoria. The morphological and biochemical characteristics of the organism indicated that it was a new Aeromonas species, for which the name A. proteolytica is proposed. When freshly isolated, the organism required seawater for growth; but, upon prolonged culture in the laboratory, it was able to grow in media of greatly reduced salt concentration, provided that relatively large amounts of peptone were supplied. Peptone or hydrolysates of casein were capable of supplying all organic nutrients required for growth and proteinase production. Certain individual amino acids were also able to furnish all energy, carbon, and nitrogen requirements. Inorganic nitrogen was utilized in the presence of citrate, but could not serve as the only source of nitrogen in the presence of glucose. The organism was facultatively anaerobic, but best growth and proteinase production occurred only with vigorous aeration. The amount of growth obtained in 24 hr increased rapidly as the incubation temperature was increased up to a maximum of 40 C, but no growth occurred at 42 C.
A comparison between clearing and radiographic techniques in the study of the root‐canal anatomy of maxillary first and second molars (2004)

It is concluded that the agreement between the two radiographic examiners and the agreement between either radiographic examiner and the clearing technique were poor to moderate, indicating the limited value of radiographs alone when studying certain aspects of the root-canal system.
New Insight into the Topical Management of Excessive Sebum Flow at the Skin Surface (1998)

The sebum flow dynamics at the skin surface results from a multistep process starting with sebocyte proliferation, intracellular lipid synthesis, cell lysis in the sebaceous duct, storage of sebum in the follicular reservoir, discharge through the follicular opening and spreading over the stratum corneum. A handful of topical products may decrease the sebum output, most of them acting at the level of the follicular reservoir function. Among them, elubiol exhibits a clinically relevant effect on oily skin.
Modeling polycrystals with regular polyhedra (2006)

Polycrystalline structure is of paramount importance to materials science and engineering. It provides an important example of a space-filling irregular network structure that also occurs in foams as well as in certain biological tissues. Therefore, seeking an accurate description of the characteristics of polycrystals is of fundamental importance. Recently, one of the authors (MEG) published a paper in which a method was devised of representation of irregular networks by regular polyhedra with curved faces. In Glicksman's method a whole class of irregular polyhedra with a given number of faces, N, is represented by a single symmetrical polyhedron with N curved faces. This paper briefly describes the topological and metric properties of these special polyhedra. They are then applied to two important problems of irregular networks: the dimensionless energy 'cost' of irregular networks, and the derivation of a 3D analogue of the von Neumann-Mullins equation for the growth rate of grains in a polycrystal.
New Approach on Cardiac Autonomic Control Estimation Based on BCG Processing (2007)

The work presents a biomedical instrument for unobtrusive heart rate variability measurement, using ballistocardiographyc (BCG) signal based on electromechanical film sensors (EMFi sensor). The ballistocardiogram acquired signals from subjects sitting on a chair is processed in order to improve its signal-to-noise ratio (SNR) using adaptive neuronal network filtering. The accuracy of beat-to-beat intervals detection using ballistocardiography was tested by comparing the heart rate obtained by simultaneously monitoring the electrocardiogram (EKG) and pulse frequency in young healthy subjects. The results show no statistically relevant differences between the heart rate obtained by BCG in comparison with EKG and pulse frequency measurement. By including wavelet analysis of the heart rate variability (HRV), the prototype system permits a more natural lifestyle monitoring of physiological parameters.