gebhart/patrepeval huggingface dataset:
Creating Human Machine Interface (HMI) Based Tests within Model-Based Design (2007)

<div class="htmlview paragraph">Many of the multimedia and convenience features in today's passenger vehicles involve Human Machine Interfaces (HMIs), such as the radio face plate or the remote key fob. The functional requirements for these systems are often written in terms of the customer interaction with the interface device. In the past, design engineers would not begin to test requirements for these systems until prototype hardware was available. However, many product development organizations are shifting from this hardware-based traditional development cycle, which relies on designing via a prototype and test iteration, to Model-Based Design. Unfortunately, testing systems with complex human machine interface requirements becomes less intuitive when the prototypes are removed from the design process, because the test cases must be scripted into the modeling environment instead of being applied directly to a prototype of the interface device. In this paper we will show how engineers can create a “soft” representation of an automotive HMI and record the test procedure when specified as a series of interactions with the interface, such as button presses. Next, we will demonstrate how the test procedure can be captured and exported to an editable file for re-use with Model-Based Design. Lastly, we will show how a test file can be used to populate a test harness within the Simulink® software environment.</div>
35 Differential DNA Replication in Insects (1996)

Insect chromosomes provide wonderful model systems to unravel the mysteries of DNA replication. Data from studies of conventional replication of insect chromosomes are compatible with a mode of semi-discontinuous replication by a set of enzymes similar to those in mammals. Normally, replication initiates just once per S phase in each replicon. During various stages of insect development, however, origins of DNA replication (ORI) at certain loci become the targets of complex developmental signals that lead to their selective activation or repression. As a result, insect chromosomes exhibit several molecular phenomena such as DNA amplification and underrepresentation that are in direct violation of the “rule of DNA constancy.” We believe that these phenomena may yield insights into more general principles for DNA replication control; understanding how a given ORI is driven to fire more than once (or not at all) during S phase may define the molecular mechanisms that direct an ORI to fire once and only once per cell cycle during conventional replication. In this chapter, we focus on the use of differential DNA replication in insect chromosomes as a model system to identify ORIs and explore the regulation of their activation. Many insect tissues become polyploid or polytene, and certain cell-cycle controls are overridden during these processes. The chapter by Carminati and Orr-Weaver (this volume) describes studies on Drosophila mutants that have provided insights into controls for progression through the cell cycle. CONVENTIONAL DNA REPLICATION IN INSECTS Replicons with Bidirectional Replication Much of our understanding of the mechanism for...
Statistical model for standard seismicity and detection of anomalies by residual analysis (1991)

A statistical point-process model is derived to describe the standard activity of earthquake occurrences by assuming that general seismicity is given by the superposition of aftershock sequences.The parameters are estimated by the maximum likelihood method.Using the estimated model, the "residual point process" of the data is defined and used to find the anomalies which are included in the data set but not captured in the considered model for the standard seismicity.For instance, seismic quiescences can be measured quantitatively by using the residual process.Some examples are provided tb illustrate such analyses.Furthermore, a time series of the magnitudes on the residual point process is considered, to investigate its dependence either on the time or on the history of the seismicity.By assuming the exponential distribution at each time and modelling of the b-value, we can examine such dependences and estimate them.Two practical examples are shown.
Antibiotic Resistance Acquired through a DNA Damage-Inducible Response in Acinetobacter baumannii (2013)

Acinetobacter baumannii is an emerging nosocomial, opportunistic pathogen that survives desiccation and quickly acquires resistance to multiple antibiotics. Escherichia coli gains antibiotic resistances by expressing genes involved in a global response to DNA damage. Therefore, we asked whether A. baumannii does the same through a yet undetermined DNA damage response akin to the E. coli paradigm. We found that recA and all of the multiple error-prone DNA polymerase V (Pol V) genes, those organized as umuDC operons and unlinked, are induced upon DNA damage in a RecA-mediated fashion. Consequently, we found that the frequency of rifampin-resistant (Rif(r)) mutants is dramatically increased upon UV treatment, alkylation damage, and desiccation, also in a RecA-mediated manner. However, in the recA insertion knockout strain, in which we could measure the recA transcript, we found that recA was induced by DNA damage, while uvrA and one of the unlinked umuC genes were somewhat derepressed in the absence of DNA damage. Thus, the mechanism regulating the A. baumannii DNA damage response is likely different from that in E. coli. Notably, it appears that the number of DNA Pol V genes may directly contribute to desiccation-induced mutagenesis. Sequences of the rpoB gene from desiccation-induced Rif(r) mutants showed a signature that was consistent with E. coli DNA polymerase V-generated base-pair substitutions and that matched that of sequenced A. baumannii clinical Rif(r) isolates. These data strongly support an A. baumannii DNA damage-inducible response that directly contributes to antibiotic resistance acquisition, particularly in hospitals where A. baumannii desiccates and tenaciously survives on equipment and surfaces.
Activation of caspase-3 in permanent and transient brain ischaemia in man (2000)

Animal studies have shown brain ischaemia to cause oxidative damage to DNA and activation of caspase-3, leading to apoptosis. These changes may be exacerbated by reperfusion. To assess caspase-3 activation after transient and permanent brain ischaemia in man, we examined brain tissue from patients who had experienced a cardiac arrest with resuscitation or an atherothrombotic brain infarct, and died 12 h to 9 days later. Sections were immunostained for activated caspase-3 or the 89 kDa caspase-3-mediated cleavage product of poly(ADP-ribose) polymerase. Brain ischaemia caused activation of caspase-3 in macrophages/microglia. Some neurons showed delayed activation of caspase-3 after cardiac arrest, but very few in atherothrombotic infarcts. In man, activation of caspase-3 plays little part in neuronal death in atherothrombotic infarcts but may contribute to delayed death of neurons after cardiac arrest.
Assistive technology solutions for aiding travel of pedestrians with visual impairment (2017)

This work systematically reviews the assistive technology solutions for pedestrians with visual impairment and reveals that most of the existing solutions address a specific part of the travel problem. Technology-centered approach with limited focus on the user needs is one of the major concerns in the design of most of the systems. State-of-the-art sensor technology and processing techniques are being used to capture details of the surrounding environment. The real challenge is in conveying this information in a simplified and understandable form especially when the alternate senses of hearing, touch, and smell have much lesser perception bandwidth than that of vision. A lot of systems are at prototyping stages and need to be evaluated and validated by the real users. Conveying the required information promptly through the preferred interface to ensure safety, orientation, and independent mobility is still an unresolved problem. Based on observations and detailed review of available literature, the authors proposed that holistic solutions need to be developed with the close involvement of users from the initial to the final validation stages. Analysis reveals that several factors need serious consideration in the design of such assistive technology solutions.
Recent Results on A-Ring Modification of 1&#945;,25-Dihydroxyvitamin D3: Design and Synthesis of VDR-Agonists and Antagonists with High Biological Activity (2006)

The structure-activity relationships of 1α,25-dihydroxyvitamin D3 on simultaneous modification at both C2α and CD-ring side chain, including 20-epimerization, double side chain (gemini), and vitamin D receptor (VDR) antagonists TEI-9647 and TEI-9648 lactone rings, and also on simultaneous modifications at both C2 and C10 positions, i.e., C2 modified active 19-norvitamin D3, have been studied in our laboratory to find new seeds of B-seco-steroidal medicine for treating bone diseases, psoriasis, secondary hyperparathyroidism, and certain kinds of cancers. We developed an efficient and systematic route to the 2α-substituted 1α,25-dihydroxyvitamin D3 analogs, i.e., VDR-agonists (20-epi-2-4, double side chain 13a-c, 19-nor 15a-c) and antagonists (36a-c, 37a-c). The A-ring precursors (11a-o) for these analogs were synthesized from D-glucose as a chiral template. In the 19-nor series, we used radical coupling reaction for preparing the A-ring parts from (-)-quinic acid, and the resulting 2-substituted A-ring moiety was coupled with 25-hydroxy Grundmanns ketone utilizing Julia olefination to connect between the C5 and C6 positions. We also synthesized the highly potent VDR-antagonists by introducing the 2α-functional group to the TEI-9647 and TEI-9648 skeletons. Keywords: palladium coupling, B-seco steroidal, HL-60 Cell Differentiation, Docking, CD-ring lactones
Detection and Identification of <i>Bartonella</i> Species Pathogenic for Humans by PCR Amplification Targeting the Riboflavin Synthase Gene ( <i>ribC</i> ) (2003)

Several Bartonella species have now been implicated as human pathogens. The recovery of these fastidious organisms in the clinical microbiology laboratory remains difficult, and current methods are still relatively insensitive. Thus, the bartonellae are good candidates for detection by PCR. We have developed a PCR assay which uses a single primer pair targeting the riboflavin synthase gene (ribC) and detected six Bartonella species that have been implicated in human disease, B. henselae, B. quintana, B. bacilliformis, B. clarridgeiae, B. elizabethae, and B. vinsonii subsp. berkhoffii. Species identification is achieved simply by restriction enzyme digestion of the amplicon. This PCR assay appears to be specific for the Bartonella genus because it failed to amplify DNA from several other bacterial species.
Discovering Knowledge from AIS Database for Application in VTS (2010)

The widespread use of the Automatic Identification System (AIS) has had a significant impact on maritime technology. AIS enables the Vessel Traffic Service (VTS) not only to offer commonly known functions such as identification, tracking and monitoring of vessels, but also to provide rich real-time information that is useful for marine traffic investigation, statistical analysis and theoretical research. However, due to the rapid accumulation of AIS observation data, the VTS platform is often unable quickly and effectively to absorb and analyze it. Traditional observation and analysis methods are becoming less suitable for the modern AIS generation of VTS. In view of this, we applied the same data mining technique used for business intelligence discovery (in Customer Relation Management (CRM) business marketing) to the analysis of AIS observation data. This recasts the marine traffic problem as a business-marketing problem and integrates technologies such as Geographic Information Systems (GIS), database management systems, data warehousing and data mining to facilitate the discovery of hidden and valuable information in a huge amount of observation data. Consequently, this provides the marine traffic managers with a useful strategic planning resource.
Wireless Sensing of Flow-Induced Vibrations for Pipeline Integrity Monitoring (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Induction and Repression of the Histidine-degrading Enzymes of Bacillus subtilis (1968)

Abstract In Bacillus subtilis a series of four enzymes is responsible for the degradation of l-histidine to ammonia, formamide, and l-glutamic acid. The third enzyme of the series was not investigated; the other three enzymes, histidase, urocanase, and formiminoglutamate hydrolase, are induced by l-histidine and repressed by catabolites. Mutants can be found in which the three enzymes are constitutive but still subject to catabolite repression. In other mutants the three enzymes are insensitive to catabolite repression but still inducible. In addition, a mutant simultaneously constitutive and resistant to catabolite repression and a mutant incapable of producing any one of the three enzymes were found. Other mutants are deficient only in histidase or only in formiminoglutamate hydrolase. The arrangement of the genes affecting the formation of these enzymes was studied by transformation. All genes are closely linked in the order: catabolite repression-inducibility-histidase-formiminoglutamate hydrolase. The mutation causing both constitutivity and insensitivity to catabolite repression may be a deletion. The site whose mutation causes inability to produce any one of the enzymes is very closely linked or allelic to the gene determining response to catabolite repression.
An implementation of a proposed modification of CAN protocol on CAN fieldbus controller component for supporting a dynamic priority policy (2004)

CAN industrial local area networks, called controller area network, are used in the framework of real-time distributed industrial applications and distributed processing systems. Such applications cover the drinking or used water adduction; the transportation and the distribution of electricity; the purification stations; the oil or gas fields exploitation; the vehicle and space engines, the automatons and robot systems in manufacturing, etc. CAN networks guarantee relatively short time latency. Due to its short frame, when one PDO (process data object) is implemented as a single CAN data frame or CAN remote frame and to its bit-to-bit arbitration. It has been shown that this random access scheme, based on CSMA/CA protocol exceeds in performance other likely techniques for wired and wireless LAN. However, this type of arbitration defines a static priority to messages exchanged. When the offered traffic approaches the system nominal bandwidth, it results in a significant growth of transmission periods to a number of stations, that appear in the calculation of the worst-case queuing delay and blocking probabilities in both MAC and physical sublayers, from there, excluding the CAN to be a realtime network. Suitable techniques for identifiers allocation have been developed to find a satisfactory way to attribute identifiers to exchanged objects, allowing all possible period limits to applications. However, some mission-critical systems (time-critical PDO) will require deterministic behavior in communication during service. Even at maximum load, the transmission of all safety related messages must be guaranteed. To solve this problem, the ideal solution is to determine the point of time when a message with a given priority will be transmitted with a high precision. Some suboptimal solutions have been proposed, like TTCAN (time triggered CAN), DiPP (distributed priority policy) and DPP (dynamic priority policy). We have proposed a dynamic priority policy, based on the reserve bits left by the protocol and on the needs expressed in necessary bandwidth, to improving the message transmission periods and to reducing the blocking probability in maximal load. We demonstrate in this paper the easy implementation of the proposed modification of CAN protocol in a CAN controller component and its compatibility with older controllers.
Sensitivity enhancement effects in the thermoluminescence of LiF TLD-100 at radiation doses below 10 Gy (1987)

LiF TLD-100 ribbons are frequently used for a wide range of radiobiological dosimetry applications using various sources in the dose range 0.1-10 Gy. It is suggested that an accuracy of 5-6% and a precision of 2-3% is required for the determination of absorbed dose in biological applications. To minimise the random errors, the dosemeters are calibrated individually. The authors examine the systematic errors that may be introduced by this procedure. They have observed, for instance, that the calibration procedure itself enhances the sensitivity of the dosemeters by 1-2% and that this enhancement is dependent upon their thermal history. They describe the procedures that have been established at the Gray Laboratory for routine precision thermoluminescence dosimetry. Particular attention is given to the sensitivity correction factor that is necessary to allow for enhancement effects due to supralinearity and the dosemeter thermal history.
Performance evaluation of an Automated Freehand Breast Ultrasound System for the completeness of scanning assessment. (2014)

Poster: ECR 2014 / C-1382 / Performance evaluation of an Automated Freehand Breast Ultrasound System for the completeness of scanning assessment. by: S. Andrei1, J. Gao1, J. Chiu2, J. Turian3, C. Caluser4; 1Villa Park, IL/US, 2Evanston, IL/US, 3Chicago, IL/US, 4Glen Ellyn, IL/US
ChemInform Abstract: Hexanuclear Rhenium Clusters: From Solid State to Solution Chemistry. The Crystal Structure of KRe6Se5Cl7(OH)2, H2O, and Its Implications (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cluster-based novel concept detection in data streams applied to intrusion detection in computer networks (2008)

In this paper, a cluster-based novelty detection technique capable of dealing with a large amount of data is presented and evaluated in the context of intrusion detection. Starting with examples of a single class that describe the normal profile, the proposed technique detects novel concepts initially as cohesive clusters of examples and later as sets of clusters in an unsupervised incremental learning fashion. Experimental results with the KDD Cup 1999 data set show that the technique is capable of dealing with data streams, successfully learning novel concepts that are pure in terms of the real class structure.
Effect of recombinant IL-10 on cultured fetal rat alveolar type II cells exposed to 65%-hyperoxia (2011)

The present study provides an experimental evidence that IL-10 may play a potential role in protection of fetal alveolar type II cells from injury induced by 65%-hyperoxia.
REVIEWS Travaux de linguistique et de littérature, publiés par le Centre de Philologie et de Littératures romanes de l'Université de Strasbourg, vol. III, fasc. 1 et 2, 1965. 206 pp. + 143 pp. (1966)

Journal Article REVIEWS Get access Travaux de linguistique et de littérature, publiés par le Centre de Philologie et de Littératures romanes de l'Université de Strasbourg, vol. III, fasc. 1 et 2, 1965. 206 pp. + 143 pp. STEPHEN ULLMANN STEPHEN ULLMANN LEEDS Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume XX, Issue 3, July 1966, Pages 322–323, https://doi.org/10.1093/fs/XX.3.322 Published: 01 July 1966
Clinical significance of BRAF (V600E) mutation and Ki-67 labeling index in papillary thyroid carcinomas. (2007)

These results suggest that PTCs with BRAF (V600E) mutation are more aggressive than those with wildtype BRAF. This mutation may be important for predicting a worse prognosis in patients with PTC.
Simultaneous treatment of concurrent rejection and tissue invasive cytomegalovirus disease without detrimental effects upon patient or allograft survival (1992)

Posttransplant cytomegalovirus (CMV) infection has been directly and temporally correlated with decreased patient and allograft survival. Because of this association, prior dogma has dictated that immunosuppression be decreased or maintained, but not increased, and thus rejection episodes have not been treated during active CMV infection. Since 1987, we have treated a group of patients who developed concurrent (within 1–3 days) mild to moderate acute rejection and mild to moderate tissue invasive CMV disease (TI‐CMV) with antirejection and antiviral therapy simultaneously. 619 patients underwent renal transplantation between 5/7/87 and 12/13/90 [535 kidney (253 living related, 282 cadaver) and 84 kidney‐pancreas]. 18 patients presented with concurrent evidence of TI‐CMV plus acute kidney or pancreas allograft rejection. Treatment consisted of iv ganciclovir (DHPG, 5 mg/kg iv q 12 h, mean = 14.4 days) for TI‐CMV and initial oral or iv steroids (followed by ALG or OKT3 in 13 patients) for rejection. At 30 days, all 18 patients with concurrent TI‐CMV and rejection were successfully treated for CMV without DHPG toxicity, although 2 allografts were lost due to unrelenting rejection requiring nephrectomy. 4 patients developed recurrent TI‐CMV and 1 patient developed recurrent rejection >30 days after simultaneous therapy, all of which were successfully treated. A total of 4 deaths occurred due to the following causes: pulmonary embolus, cerebrovascular accident. Candida sepsis, and Aspergillus sepsis, the latter subsequent to treatment of recurrent rejection. We analyzed outcome in patients who developed TI‐CMV post‐rejection (> 14 days) or TI‐CMV without rejection and who received DHPG. and noted that patient and allograft survival was not statistically different compared to patients who received simultaneous therapy for both disease processes (p>0.05). Recipients with or without rejection who never developed TI‐CMV. however, did exhibit increased patient and allograft survival when compared to those who were treated for TI‐CMV alone or simultaneous TI‐CMV plus rejection (p<0.01). Based upon this analysis, we concluded that: 1) simultaneous treatment of concurrent TI‐CMV and acute rejection is feasible, and 2) this docs not magnify the adverse effects related to TI‐CMV alone, and recommended that: 1) antirejection therapy be instituted with simultaneous administration of DHPG in patient with proven rejection and suspected TI‐CMV. 2) the diagnostic work‐up for CMV and other pathogens should be vigorously pursued in this setting, and 3) if evidence of progression of CMV disease occurs (despite absence of this event in this series) that antirejection therapy be withdrawn.