gebhart/patrepeval huggingface dataset:
Optical Pump-Probe Measurements of Local Nuclear Spin Coherence in Semiconductor Quantum Wells (2006)

We demonstrate local manipulation and detection of nuclear spin coherence in semiconductor quantum wells by an optical pump-probe technique combined with pulse rf NMR. The Larmor precession of photoexcited electron spins is monitored by time-resolved Kerr rotation (TRKR) as a measure of nuclear magnetic field. Under the irradiation of resonant pulsed rf magnetic fields, Rabi oscillations of nuclear spins are traced by TRKR signals. The intrinsic coherence time evaluated by a spin-echo technique reveals the dependence on the orientation of the magnetic field with respect to the crystalline axis as expected by the nearest neighbor dipole-dipole interaction.
Zinc Potentiates the Antiviral Action of Human IFN- <i>α</i> Tenfold (2001)

During the last decade, various zinc salts have been used against the common cold syndrome, which is known to be initiated by respiratory viruses, particularly rhinoviruses. Using rhinovirus as the challenge virus, we investigated whether zinc salts (Zn) could potentiate the antiviral action of native human leukocyte interferon (HuIFN-alpha) and rHuIFN-gamma. We found that HuIFN-alpha was potentiated tenfold at rather low levels of IFN activity (0.6-0.8 U/ml), resulting in 100% protection. Zn alone gave only marginal protection, if any. In contrast to HuIFN-alpha, rHuIFN-gamma directly increased the cytopathic effect of rhinovirus at low levels (<2 U/ml) but protected the cells at higher IFN levels (5-20 U/ml). No potentiation was seen with Zn. HuIFN-beta protected against rhinovirus at the same doses as used with HuIFN-alpha, but in contrast to HuIFN-alpha, no potentiation was noted.
Low dose interferon-alpha2b combined with PUVA is an effective treatment of early stage mycosis fungoides: results of a multicenter study. Cutaneous-T Cell Lymphoma Multicenter Study Group. (1999)

Even with low doses of IFNalpha plus PUVA it is possible to achieve excellent clinical responses,many of which are long-lasting, in patients with early MF.
Late-Onset Hypogonadism and Mortality in Aging Men (2013)

Severe LOH is associated with substantially higher risks of all-cause and cardiovascular mortality, to which both the level of T and the presence of sexual symptoms contribute independently. Detecting low T in men presenting with sexual symptoms offers an opportunity to identify a small subgroup of aging men at particularly high risk of dying.
DECORATING WITH SUGARS MADE EASY (2005)

RETURN TO ISSUEPREVNewsNEXTDECORATING WITH SUGARS MADE EASYNew synthetic approach converts heart drug to potential anticancer agentSTU B0RMANCite this: Chem. Eng. News 2005, 83, 33, 7Publication Date (Print):August 15, 2005Publication History Published online14 November 2010Published inissue 15 August 2005https://pubs.acs.org/doi/10.1021/cen-v083n033.p007https://doi.org/10.1021/cen-v083n033.p007newsACS PublicationsCopyright © 2005 American Chemical SocietyArticle Views8Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Carbohydrates Get e-Alerts
WEB RECOMMENDATION SYSTEM BASED ON A MARKOV-CHAIN MODEL (2005)

This work presents some general procedures for computing dissimilarities between nodes of a weighted, undirected, graph. It is based on a Markov-chain model of random walk through the graph. This method is applied on the architecture of a Multi Agent System (MAS), in which each agent can be considered as a node and each interaction between two agents as a link. The model assigns transition probabilities to the links between agents, so that a random walker can jump from agent to agent. Two quantities, called the average commute time and the pseudoinverse of the Laplacian matrix of the graph, provide proximity measures between any pair of agents. The model is applied on a collaborative filtering task where suggestions are made about which movies people should watch based upon what they watched in the past. For the experiments, we build a MAS architecture and instantiated the agents belief set from a real movie database.
<i>O</i>‐Glycosylation in <i>Saccharomyces cerevisiae</i> is initiated at the endoplasmic reticulum (1983)

The first mannose of O-linked oligomannose chains in S. cerevisiae is transferred to Ser/Thr residues via dolichylphosphate mannose. Only this reaction (and not the subsequent reactions requiring GDP-Man) proceeds at the endoplasmic reticulum.
Neuroprotection by Acetyl-<i>L</i>-Carnitine after Traumatic Injury to the Immature Rat Brain (2010)

Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in children and is characterized by reduced aerobic cerebral energy metabolism early after injury, possibly due to impaired activity of the pyruvate dehydrogenase complex. Exogenous acetyl-L-carnitine (ALCAR) is metabolized in the brain to acetyl coenzyme A and subsequently enters the tricarboxylic acid cycle. ALCAR administration is neuroprotective in animal models of cerebral ischemia and spinal cord injury, but has not been tested for TBI. This study tested the hypothesis that treatment with ALCAR during the first 24 h following TBI in immature rats improves neurologic outcome and reduces cortical lesion volume. Postnatal day 21-22 male rats were isoflurane anesthetized and used in a controlled cortical impact model of TBI to the left parietal cortex. At 1, 4, 12 and 23 h after injury, rats received ALCAR (100 mg/kg, intraperitoneally) or drug vehicle (normal saline). On days 3-7 after surgery, behavior was assessed using beam walking and novel object recognition tests. On day 7, rats were transcardially perfused and brains were harvested for histological assessment of cortical lesion volume, using stereology. Injured animals displayed a significant increase in foot slips compared to sham-operated rats (6 ± 1 SEM vs. 2 ± 0.2 on day 3 after trauma; n = 7; p < 0.05). The ALCAR-treated rats were not different from shams and had fewer foot slips compared to vehicle-treated animals (2 ± 0.4; n = 7; p< 0.05). The frequency of investigating a novel object for saline-treated TBI animals was reduced compared to shams (45 ± 5% vs. 65 ± 10%; n = 7; p < 0.05), whereas the frequency of investigation for TBI rats treated with ALCAR was not significantly different from that of shams but significantly higher than that of saline-treated TBI rats (68 ± 7; p < 0.05). The left parietal cortical lesion volume, expressed as a percentage of the volume of tissue in the right hemisphere, was significantly smaller in ALCAR-treated than in vehicle-treated TBI rats (14 ± 5% vs. 28 ± 6%; p < 0.05). We conclude that treatment with ALCAR during the first 24 h after TBI improves behavioral outcomes and reduces brain lesion volume in immature rats within the first 7 days after injury.
High‐throughput analysis of GST‐fusion protein expression and activity‐dependent protein interactions on GST‐fusion protein arrays with a spectral surface plasmon resonance biosensor (2006)

We modified gold arrays with a glutathione (GSH) surface, and investigated high-throughput protein interactions with a spectral surface plasmon resonance (SPR) biosensor. We fabricated the GSH exterior on gold surfaces by successive modification with aminoethanethiol, 4-maleimidobutyric acid N-hydroxysuccinimide ester and GSH. We immobilized GST-Rac1, GST-RhoA, the GST-Rho-binding domain of rhotekin and the GST-p21-binding domain of PAK1 onto the GSH surface, and observed specific antigen-antibody interactions on the GST-fusion protein arrays. We determined the expression of GST-fusion proteins in Escherichia coli on the GSH surface with the SPR biosensor. We then analyzed the interactions of tissue transglutaminase (tTGase), a Ca2+-dependent enzyme, with RhoA and Rac1 on the GST-fusion protein arrays with the SPR biosensor. We found that tTGase interacted with RhoA and Rac1 in a Ca2+-dependent manner, indicating that the interactions were dependent on tTGase activity. In addition, transamidation of Rac1 by tTGase was dependent on Ca2+ concentration. We obtained similar results with GST pull-down assays. Thus, protein arrays prepared on the GSH surface provide a useful system for the high-throughput analysis of GST-fusion protein expression and activity-dependent protein interactions with the spectral SPR biosensors.
Mapping of the resistivity, susceptibility, and permittivity of the earth using a helicopter-borne electromagnetic system (2001)

Abstract Interpretation of helicopter-borne electromagnetic (EM) data is commonly based on the mapping of resistivity (or conductivity) under the assumption that the magnetic permeability is that of free space and dielectric permittivity can be ignored. However, the data obtained from a multifrequency EM system may contain information about the magnetic permeability and dielectric permittivity as well as the conductivity. Our previous work has shown how helicopter EM data may be transformed to yield the resistivity and magnetic permeability or, alternatively, the resistivity and dielectric permittivity. A method has now been developed to recover the resistivity, magnetic permeability, and dielectric permittivity together from the transformation of helicopter EM data based on a half-space model. A field example is presented from an area which exhibits both permeable and dielectric properties. This example shows that the mapping of resistivity, magnetic permeability, and dielectric permittivity together yields more credible results than if the permeability or permittivity is ignored.
Discovering Antisense Reagents by Hybridization of RNA to Oligonucleotide Arrays (2007)

Antisense reagents have the potential to modify gene expression by interacting with DNA or mRNA to down-regulate transcription or translation. There have been a number of successful demonstrations of antisense activity in vivo. However, a number of problems must be solved before the method's full potential can be realized. One problem is the need for the antisense agent to form a duplex with the target molecule. We have found that most regions of mRNAs are not open to duplex formation with oligonucleotides because the bases needed for Watson-Crick base pairing are involved in intramolecular pairing. Using arrays of oligonucleotides that are complementary to extensive regions of the mRNA target, we are able to find those antisense oligonucleotides which bind optimally. There is good correspondence between the ability of an oligonucleotide to bind to its target and its activity as an antisense agent in in vivo and in vitro tests. To understand more fully the rules governing the process of duplex formation between a native RNA and complementary oligonucleotides, we have studied the interactions between tRNAphe and a complete set of complementary dodecanucleotides. Only four of the set of 65 oligonucleotides interact strongly. The four corresponding regions in the tRNA share structural features. However, other regions with similar features do not form a duplex. It is clear that ab initio prediction of patterns of interaction require much greater knowledge of the process of duplex formation than is presently available.
<sup>1</sup>H 2D MRSI tissue type analysis of gliomas (2014)

LCModel can be used to decompose 1H MR spectra into proportions of normal and abnormal tissue to identify tumor extent, infiltration, and overall grade.
Sub-Halfmicron Lithography Using a High-Contrast i-Line CEL (1990)

A newly developed, metal-free, water soluble i-line CEL and its patterning features are described. A, B and C parameters of CEL are 18 µm -1 , 0.12 µm -1 , and 0.09 cm 2 /mJ, respectively. CEL changes the γ value from 3 to 20. This CEL material makes patterns with an aerial image contrast of 0.4 possible. This result suggests that 0.3 µm microfabrication is possible with an i-line lithography that has a high numerical aperture lens.
Some immunogenic and biochemical properties of tumor‐associated transplantation antigens (TATA) obtained in soluble form or solubilized from two methylcholanthrene‐induced sarcomas, meth A and CI‐4 (1981)

The subcellular distribution of the tumor-associated transplantation antigens (TATAs) of two highly immunogenic methylcholanthrene-induced sarcomas, Meth A and CI-4, were compared. Most of the TATA of CI-4 was found in the soluble fraction (cytosol) of the cell while the TATA from Meth A was variably distributed between the membrane and cytosol. The soluble fraction TATAs from both tumors were very immunogenic and their strong immunity could not be influenced by administering antigen in a variety of protocols that altered the immune response in other systems. The soluble fraction and membrane-associated TATAs from both tumors could be specifically bound to liposomes in reconstitution experiments and the antigenicity of all of the TATAs was significantly enhanced when they were incorporated into these artificial membranes.
Crystal Structure of Human l-Isoaspartyl Methyltransferase (2002)

The enzyme l-isoaspartyl methyltransferase initiates the repair of damaged proteins by recognizing and methylating isomerized and racemized aspartyl residues in aging proteins. The crystal structure of the human enzyme containing a bound S-adenosyl-l-homocysteine cofactor is reported here at a resolution of 2.1 A. A comparison of the human enzyme to homologs from two other species reveals several significant differences among otherwise similar structures. In all three structures, we find that three conserved charged residues are buried in the protein interior near the active site. Electrostatics calculations suggest that these buried charges might make significant contributions to the energetics of binding the charged S-adenosyl-l-methionine cofactor and to catalysis. We suggest a possible structural explanation for the observed differences in reactivity toward the structurally similar l-isoaspartyl and d-aspartyl residues in the human, archael, and eubacterial enzymes. Finally, the human structure reveals that the known genetic polymorphism at residue 119 (Val/Ile) maps to an exposed region away from the active site.
Histochemistry. I. Ginsenosides in Ginseng (Panax ginseng C. A. Meyer, Root) (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHistochemistry. I. Ginsenosides in Ginseng (Panax ginseng C. A. Meyer, Root)Michinori Kubo, Tadato Tani, Tadahisa Katsuki, Keishi Ishizaki, and Shigeru ArichiCite this: J. Nat. Prod. 1980, 43, 2, 278–284Publication Date (Print):March 1, 1980Publication History Published online1 July 2004Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/np50008a006https://doi.org/10.1021/np50008a006research-articleACS PublicationsRequest reuse permissionsArticle Views299Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improvement in the Negative Bias Illumination Stress Stability for Silicon-Ion Implanted Amorphous InGaZnO Thin-Film Transistors (2017)

Using ion implantation, we doped amorphous InGaZnO (a-IGZO) with Si and investigated how this doping influenced device performance. The Si doping increased the electrical conductivity of the a-IGZO films, showing that the Si doping had produced the electron carriers. The optimum oxygen partial pressure during a-IGZO deposition moved toward higher in the Si-implanted a-IGZO thin-film transistors (TFTs) than in the undoped TFTs. In the doped TFTs, the gate bias stability against negative bias illumination stress (NBIS) improved, while the mobility remained almost the same as that without Si doping. This improvement in the NBIS stability suggests that the subgap states related to oxygen-vacancies could be reduced in the Si-implanted a-IGZO film.
Enabling Information Centric Networking in IP Networks Using SDN (2013)

In this paper, we show how to enable Information- Centric Networking (ICN) on existing IP networks, such as ISP or data center networks, using Software-Defined Networking (SDN) functions and control. We describe a mechanism that (i) enables addressing and transfer through non-SDN controlled networks (i. e., the Internet), (ii) allows to identify ICN requests and responses, (iii) decouples forwarding from the object name, (iv) requires neither new or extended network/L3 and transport/L4 protocols nor changes of client and server OS, and (v) supports aggregation of routes inside the SDN controlled network. In addition, the proposed solution is agnostic of the specific ICN protocol in use, and does not require all network elements to be SDN-enabled. It supports advanced ICN routing features like request aggregation and forking, as well as loadbalancing, traffic engineering, and explicit path steering (e. g., through ICN caches). We present the design as well as our first implementation of the proposed scheme-based on the Trema OpenFlow controller-framework and CCNx-along with initial performance measurements showing the feasibility of our approach.
Ultrashort-pulse propagation in optical fibers (1990)

A more exact model is suggested for the description of nonlinear light propagation in fibers. In addition to the previously discussed self-phase modulation, parametric, dispersion, self-steepening, and Raman self-scattering effects, this model also takes into account the Stokes losses associated with the material excitation, the dependence of nonlinear effects on the light frequency, and the frequency dependence of the fiber mode area. The self-steepening effect is taken into account more correctly in comparison with previous models. The effects influence considerably the femtosecond soliton propagation. The model is generalized for the case of various fiber dispersion properties along the fiber length. The possibility of obtaining high-quality pulses of less than 15-fsec duration by compression of fundamental solitons with approximately 100-fsec duration in fibers with slowly decreasing dispersion is shown.
Interaction of the N-terminal region of hirudin with the active-site cleft of thrombin (1992)

Site-specific substitutions of the first five amino acids of the thrombin inhibitor hirudin have been made and the effects of these substitutions on the kinetics of formation of the thrombin-hirudin complex evaluated. The effects of different substitutions of Val1 indicate that nonpolar interactions play a major role in the binding of this residue. In the second position (Val2), polar amino acids were better accommodated than in the first. The mutant with arginine in the second position bound particularly well to thrombin; its dissociation constant was 9-fold lower than that of wild-type recombinant hirudin. Comparison of the effects of single and double mutations involving Val1 and Val2 indicates that there was no cooperativity in the binding of these two residues. Elimination of the hydrophobic interactions made by the aromatic ring of Tyr3 of hirudin resulted in a large loss of binding energy (12.7 kJ mol-1). Replacement of Thr4 of hirudin by serine and alanine suggested that both the gamma-methyl and the hydroxyl group of the threonine were important in the stabilization of the thrombin-hirudin complex. Replacement of Asp5 of hirudin by alanine and glutamate caused about the same loss in binding energy (5 kJ mol-1). The effects of site-specific substitutions are discussed in terms of the crystal structure of the thrombin-hirudin complex. Molecular modeling provided plausible explanations for many of the observed effects. For instance, such studies suggested that the improved binding of the mutant with arginine in the second position could be due to an interaction of the arginine with the primary specificity pocket.
The Molecular Pathology of Autoimmune Diseases (2002)

Remarkable advances have been made in the pathogenesis of autoimmunity, such as with bone marrow transplantation, which is becoming a powerful strategy in treating certain life-threatening diseases. The Molecular Pathology of Autoimmune Diseases is a concise and centralized resource for information on the topic, with a special focus on the molecula
<i>Retracted on February 24, 2022</i> : Using Virtual Reality to Teach Students How to be CFO (2021)

NOTICE OF RETRACTION: While investigating potential publication-related misconduct in connection with the ICIMTech 2021 Conference Proceedings, serious concerns were raised that cast doubt on the integrity of the peer-review process and all papers published in the Proceedings of this Conference. The integrity of the entire Conference has been called into question. As a result, of its investigation, ACM has decided to retract the Entire Conference Proceedings and all related papers from the ACM Digital Library.
The Internet is not TV (1995)

Don't turn the page. This is not yet-another article on how great the World-Wide Web is, and how fast it is growing. By now you must have read many of those, and surfed the Web a bit. But, the Internet is not television—are you ready to become a Web author? This article describes tools and considerations for publishing on them Web, and looks toward the future. Let's start with server platfroms.