gebhart/patrepeval huggingface dataset:
Heparin potentiates the action of plasma membrane‐associated growth stimulatory activity (1987)

Plasma membranes prepared from mouse liver have been previously shown to contain growth stimulatory activity as determined with cultured mouse fibroblasts. This growth stimulatory activity, termed plasma membrane-associated growth stimulatory activity (PMGA), is highly mitogenic in the presence of platelet-poor plasma. We now demonstrate that the growth stimulatory action of PMGA is dramatically enhanced by the addition of heparin. The half-maximal effect of heparin was observed at 1-3 micrograms/ml. The synergistic effect was seen in two distinct assays; the stimulation of DNA synthesis in quiescent cells, and an increase of cell number over a 3-day culture period. Heparin, by itself, does not have any measurable influence on the growth of fibroblasts. The action of heparin is not unique to this glycosaminoglycan, as several other highly sulfated polysaccharides, including dextran sulfate, pentosan polysulfate, and fucoidan, also exhibited the highly synergistic effect. Among other glycosaminoglycans examined, chondroitin sulfate B and heparan sulfate had a small, but significant, effect on enhancing the growth stimulatory action of PMGA. Chondroitin sulfate A, chondroitin sulfate C, hyaluronic acid dextran, and poly-L-glutamic acid, however, had no detectable effect. Further experiments suggested that the effect of heparin is twofold, namely, both a potentiation of growth stimulatory activity and a protection of PMGA activity. The data presented here suggest that the association of various cell surface components, such as PMGA and specific proteoglycans, can modulate the growth potential of a cell.
A vertically aligned carbon nanotube-based impedance sensing biosensor for rapid and high sensitive detection of cancer cells (2012)

A novel vertically aligned carbon nanotube based electrical cell impedance sensing biosensor (CNT-ECIS) was demonstrated for the first time as a more rapid, sensitive and specific device for the detection of cancer cells. This biosensor is based on the fast entrapment of cancer cells on vertically aligned carbon nanotube arrays and leads to mechanical and electrical interactions between CNT tips and entrapped cell membranes, changing the impedance of the biosensor. CNT-ECIS was fabricated through a photolithography process on Ni/SiO(2)/Si layers. Carbon nanotube arrays have been grown on 9 nm thick patterned Ni microelectrodes by DC-PECVD. SW48 colon cancer cells were passed over the surface of CNT covered electrodes to be specifically entrapped on elastic nanotube beams. CNT arrays act as both adhesive and conductive agents and impedance changes occurred as fast as 30 s (for whole entrapment and signaling processes). CNT-ECIS detected the cancer cells with the concentration as low as 4000 cells cm(-2) on its surface and a sensitivity of 1.7 × 10(-3)Ω cm(2). Time and cell efficiency factor (TEF and CEF) parameters were defined which describe the sensor's rapidness and resolution, respectively. TEF and CEF of CNT-ECIS were much higher than other cell based electrical biosensors which are compared in this paper.
Loss of an HLA haplotype in pancreas cancer tissue and its corresponding tumor derived cell line (1996)

A combination of immunohistochemical, biochemical, and recombinant DNA techniques were used to investigate class I expression in 26 pancreatic adenocarcinomas and 6 autologous tumor-derived cells. The prevalence of HLA losses was found to be comparable to that observed in other tumor types (> 35%), using monomorphic and locus-specific antibodies. In one patient, the original tumor tissue, a tumor derived cell line (IMIM-PC-2), and EBV-transformed lymphocytes were available for study. The patient's phenotype was A25, A30, B18, B18. However, A30 allele product could not be detected in the original tumor not in the cultured tumor cells. In addition, A30 allele could not be isolated from cDNA or genomic clones from the cultured tumor cells whereas it was isolated from the autologous lymphoblastoid cell line. Using isoelectric focusing analysis a significant reduction in the B18 heavy chain product was also observed in the tumor cell line, IMIM-PC-2, suggesting the absence of expression of one allele. Further studies revealed loss of heterozygosity at DR and other loci of chromosome 6 and cytogenetic data strongly suggested deletion of a full chromosome 6. This work indicates for the first time that loss of a full HLA haplotype occurs in tumor tissue and suggests that this mechanism may contribute to the progression of human cancer.
A research agenda for vehicle information systems (2018)

As modern cars have transformed to computers on wheels, digitalization is an important driver of ser-vice and business innovation within the automotive domain. As a new class of information systems (IS), vehicle information systems (Vehicle IS) are enabled through the data generated by a plethora of different sensors within modern vehicles, meshed up with data from a variety of different other sources. Expecting the awareness on and the needs for Vehicle IS to steadily increase in the future - as a result of the continuing provision of driver assistance systems towards fully automation - we investigate existing literature on Vehicle IS published by the academic IS community. To get an overview on topics discussed so far as well as publication activity in general, we use the AIS Electronic Library as an indicator. We then provide a definition of the term âvehicle information systemâ and give an overview of relevant research directions with a set of example research questions, which we deem important for the academic IS community to advance the state-of-the-art in designing Vehicle IS.
Whole body magnetic resonance imaging (2004)

A valuable adjunct to clinical examination 

When Lauterbur and Damadian described the application of magnetic resonance imaging (MRI) as a clinical imaging tool in the early 1970s the popular belief was that the technique would become the ultimate screening tool for the whole body.1 2 However, similar to other modalities limited by cost, acquisition times, availability, and artefact produced by motion, it evolved as a technique to image stationary body parts. Supported by technical developments in the past decade, improved excitatory pulse sequences, and faster methods of localising derived signal, and by increasing awareness of the hazards of radiation imposed by traditional techniques, the ability to use MRI as a rapid imaging tool for the whole body has now been revisited.3–11 Reduced acquisition times have been mirrored by a logical reduction in acquisition costs, and the recent development of the moving MRI table top has facilitated the clinical introduction of this technique as a practical diagnostic tool.3

The principal application of whole body MRI is in detecting skeletal metastases as an alternative …
Oracle Sql*Loader: The Definitive Guide (2001)

From the Publisher:
SQL*Loader is a ubiquitous tool in the Oracle world. It has been shipped with Oracle since at least Version 6 and continues to be supported and enhanced with each new version of Oracle, including Oracle8 and Oracle8i. The job of SQL*Loader is to load data from flat files into an Oracle database. It's optimized for loading large volumes of data, and is flexible enough to handle virtually any input format. 
Almost every Oracle user has to use SQL*Loader at one time or another, and DBAs are frequently called upon to load data for the users in their organization. Despite SQL*Loader's wide availability and usage, few DBAs and developers know how to get the most out of it. Oracle SQL*Loader: The Definitive Guide has everything you need to know to put SQL*Loader to its best use: an introduction to SQL*Loader, a reference to all of its syntax options, and most importantly, step-by-step instructions for all the SQL*Loader tasks you'd want to performand maybe some you didn't realize you COULD perform. 
You'll learn how to construct the necessary control files and load from different types of files containing different types of data (e.g., fixed-width data, delimited data, and data of various datatypes). You'll also learn how to validate data, load it selectively, transform it as it is loaded, and recover after failure. This book explains how to optimize SQL*Loader performance by adjusting the transaction size and using the new direct path option. It also covers the newest SQL*Loader featuresthe loading of large object (LOB) columns and the new object types (nested tables, varying arrays, and object tables). 
Oracle SQL*Loader: The DefinitiveGuide is an indispensable resource for anyone who is new to SQL*Loader; a task-oriented learning tool for those who are already using it; and a quick reference for every user. If you want to take best advantage of an essential Oracle tool, you need this book.
Direct Contracting (1996)

Can a health care model in which employees choose-and pay for-their own health care revolutionize the industry?Let's look at the bellwether state of Minnesota to find out.~
The Signal Recognition Particle Database (SRPDB) (1998)

This release of the SRPDB (signal recognition particle database, http://pegasus.uthct.edu/SRPDB/SRPDB . html ) adds four SRP RNA sequences (a total of 99 SRP RNA sequences), 23 SRP protein sequences (a total of 63 protein sequences from SRP9, SRP14, SRP19, SRP21, SRP54, SRP68 or SRP72), and, for the first time, sequences of the alpha subunit of the eukaryotic SRP receptor and its homologous bacterial proteins (a total of 21 sequences). Sequences are offered phylogenetically ordered, annotated with links to the primary databases, and in aligned form. Also downloadable are sample SRP RNA secondary structure diagrams, three-dimensional models of representative SRP RNAs, and search motifs.
Effect of Endosulfan and Chlorpyriphos on Humoral Immune Response in Chickens (2012)

The effect of endosulfan and chlorpyriphos on humoral immune response was studied in one hundred chicks of 2 weeks age for a period of 2 months using “No Observable Adverse Effects Level” (NOAEL) dose. Chicks were divided into 3 groups and vaccinated with New Castle Disease Vaccine. B-lymphocyte blastogenesis assay using lipopolysaccharide as mitogen and ELISA was performed to assess humoral immune response in chicks. There was significant reduction in specific antibody titres against “New Castle Disease” Vaccine and reduction in B lymphocyte blastogenesis in pesticides fed birds indicating immunosuppressive effect of endosulfan and chlorpyriphos.
Schaum's Outline of Theory and Problems of Genetics (1991)

Schaum's outline of theory and problems of genetics , Schaum's outline of theory and problems of genetics , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
The unsweetened truth: A study guide to 'That sugar film' (2015)

It's one of the most keenly debated dietary topics in the Western world: just what is sugar really doing to our bodies? At a time when even bread is commonly sweetened, it's an issue that everyone needs to be aware of from a young age. Kim Edwards explores how this entertaining new film can prompt student discussions about the issue itself as well as the mechanics of the documentary form.
Asymmetric Counteranion‐Directed Catalysis (2006)

Exceedingly high enantioselectivity in a catalytic reaction can be realized even when the chirality resides only in the counteranion of the catalyst. A salt (1) composed of an achiral ammonium cation and a chiral phosphate counteranion catalyzes asymmetric transfer hydrogenations of aromatic and aliphatic α,β-unsaturated aldehydes with a Hantzsch ester in excellent enantioselectivities (see scheme).
Neovascularisation associated with posterior uveitis. (1987)

Twenty-six patients (39 eyes) with retinal neovascularisation associated with ocular inflammation were identified from the retinal vasculitis clinic at St Thomas's Hospital. Eight patients had sarcoidosis, seven patients Behçet's disease, and 11 had idiopathic retinal vasculitis. Twenty-three patients had required systemic therapy to control the inflammation and 11 patients received laser photocoagulation. Fluorescein angiography showed significant capillary closure in 15 eyes and diffuse microvascular leakage in the remaining 24 eyes. All patients had posterior vitreous detachment. The visual prognosis was good despite vitreous haemorrhage being the presenting feature in 22 eyes, and the new vessels resolved in 70% of cases. However, laser treatment was followed by a significant increase in cystoid macular oedema (p less than 0.01). This retrospective study suggests that medical therapy is the first line of treatment in this group of patients. Photocoagulation should be performed when the eye is quiet and should be reserved for patients with recurrent vitreous haemorrhages and significant capillary closure.
Acute effect of pretreatment with single conventional dose of salmeterol on dose-response curve to oxitropium bromide in chronic obstructive pulmonary disease (1999)

This study shows that acute pretreatment with 50 microg salmeterol does not block the possibility of inducing more bronchodilation with an anticholinergic agent when a higher than normal dosage of the muscarinic antagonist is used.
HYDRIDES OF COBALT (1946)

Hydrides of cobalt (mono and di) have been prepared according to the method described previously (<em>J</em><strong><em>.</em></strong><em> Indian Chem. Soc., </em>1943<strong><em>, </em></strong>20, 213), and their properties studied. Dissociation pres­sures of the hydrides at different temperatures have been measured and their heats of formation calculated from the dissociation pressures. The apparatus previously described has been improved upon and data on dissociation pressures of nickel hydrides redetermined.
Correlation between circulating CD27<sup>high</sup> plasma cells and disease activity in patients with systemic lupus erythematosus (2003)

Flow cytometric monitoring of B cell subsets in the peripheral blood provides new insights into abnormalities of B cell function in SLE and may also be a diagnostically valuable option for monitoring the activity of this autoimmune disease.
High-Performance Liquid Chromatographic Method Development and Validation for the Simultaneous Quantitation of Naproxen Sodium and Pseudoephedrine Hydrochloride Impurities (2001)

A reversed-phase high-performance liquid chromatographic procedure for the simultaneous determination of impurities associated with pseudoephedrine hydrochloride (PSEH) and naproxen sodium (NapNa) is developed and validated. The method is developed using a Waters Spherisorb cyano column (5 microm, 250 x 4.6 mm). An isocratic elution in a water-acetonitrile-methanol-triethylamine mixture (850:75:75:5) is adjusted to a pH of 3.7 +/- 0.02 with formic acid as the mobile phase. The UV detection was set at 260 nm, and the wavelength was switched to 235 nm before the elution of the last component, 2-ethyl-6-methoxy-naphthalene (EMN). The method is shown to be linear at a concentration range of 0.24 to 1.92 microg/mL for benzaldehyde, benzoic acid, and 2-(methylamino)-propiophenone hydrochloride, which are known impurities of PSEH. The NapNa impurities, 2-(6'-hydroxy-2'-naphthyl) propionic acid, 2-hydroxy-6-methoxy-naphthalene, 1-(6'-methoxy-2'-naphthyl) ethanol, 2-acetyl-6-methoxy-naphthalene, and EMN are also demonstrated to be linear at a concentration range of 0.44 to 3.52 microg/mL. Under the chromatographic conditions of the method, all impurities are resolved from the active components.
Solitary wave dynamics in generalized Hertz chains: An improved solution of the equation of motion (2001)

The equation of motion for a bead in a chain of uncompressed elastic beads in contact that interact via the potential V(delta) approximately delta( n), n>2, delta being overlap, supports solitary waves and does not accommodate sound propagation [V. Nesterenko, J. Appl. Mech. Tech. Phys. 5, 733 (1983)]. We present an iteratively exact solution to describe the solitary wave as a function of material parameters and a universal, infinite set of coefficients, which depend only on n. We compute any arbitrary number of coefficients to desired accuracy and show that only the first few coefficients of our solution significantly improves upon Nesterenko's solution. The improved solution is a necessary step to develop a theoretical understanding of the formation of secondary solitary waves [M. Manciu, et al., Phys. Rev. E 63, 011614 (2001)].
Polymer embossing tools for rapid prototyping of plastic microfluidic devices (2003)

In this paper, we describe a simple and rapid method of fabricating hot embossing tools using polydimethylsiloxane (PDMS), which are then used to rapidly fabricate microchannels in polymethylmethacrylate (PMMA). A negative photoepoxy SU-8 or thick positive photoresist AZ4620 on silicon was used for molding during PDMS casting. Fabrication time of these PDMS tools was considerably less than those using conventional techniques and remains the same regardless of the aspect ratio of features. The described approach was used to emboss microchannels in PMMA of aspect ratios up to 2, with depths from 5 to 250 µm and widths over 40 µm. The technique was also applied to fabricating orthogonal 3D microchannels using multiple lithography steps. The use of a soft tool material increased cycle time and limited the tool lifetime to approximately 20 cycles. Our successful demonstration of PDMS embossing tools presents an alternative approach for rapidly prototyping microfluidic biochips when fast processing and low cost are important and the number of samples is relatively low.
A method for the identification and characterization of clusters of schools along the transect lines of fisheries-acoustic surveys (2003)

Abstract The school-aggregation pattern (schools and clusters of schools) is presumed to play a significant role in determining pelagic fish-stock catchability. However, its analysis has seldom been undertaken because it requires field-behavioural data that is seldom available. Such information can now be obtained by analysing school-based data of fisheries-acoustic surveys. This paper proposes a method for doing so. The method allows for the identification of clusters of schools and the estimation of their parameters along one-dimensional, acoustic-survey transect lines. It is based on a spatial point-process approach that considers schools as point events occurring along the track sailed by a ship. More precisely, it is based on defining a maximum distance between schools in a cluster. This distance is chosen to optimize various criteria and in particular that of homogeneity concerning school location inside the clusters and school number per km. The algorithm is described and applied to a series of acoustic surveys carried out in the Bay of Biscay. The pertinence of the clusters obtained by the algorithm is evaluated by analysing which component of the spatial distribution of the schools corresponds to those clusters. This involves considering all the distances between school events and performing simulations of cluster point processes. The school clusters obtained by the proposed algorithm represent a small-range structure of a few kilometres when a longer-range structure of tens of kilometres was also present in the data.
SYMCELL-a symbolic standard cell system (1991)

A SYMCELL system is used to create research VLSI prototypes because it permits rapid realization of reasonably high-performance chips. The SYMCELL process flow consists of library creation; schematic capture and logic simulation; netlist translation; layout planning (cell placement and global routing); layout implementation (cell gridding and fine routing); layout verification and simulation; and chip assembly. SYMCELL is a standard cell system that enables cells to be created, placed, and globally routed symbolically. After this symbolic realization, cell rows are compacted and pitch-matched and channels are routed for a specific set of layout rules. The symbolic cell libraries can be maintained independently of the process layout rules, and new cells can be created with the ease of symbolic layout. The system is especially useful in research because of the ease with which the cell library can be mapped to new sets of layout rules.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Application of erythro-2-Amino-1,2-diphenylethanol as a Highly Efficient Chiral Auxiliary. Highly Stereoselective Staudinger-Type β-Lactam Synthesis Using a 2-Chloro-1-methylpyridinium Salt as the Dehydrating Agent (1998)

Staudinger-type reaction - [2 + 2] cycloaddition - β-lactams - 2-chloro-1-methylpyridinium salt - (1S,2R)-2-amino-1,2-diphenylethanol
Synergistic effects of muscarinic agonists and secretin or vasoactive intestinal peptide on the regulation of tyrosine hydroxylase activity in sympathetic neurons (2000)

Cholinergic agonists and certain peptides of the glucagon-secretin family acutely increase tyrosine hydroxylase activity in the superior cervical ganglion in vitro. The present study was designed to investigate possible interactions between these two classes of agonists in regulating catecholamine biosynthesis. Synergistic effects were found between carbachol and either secretin or vasoactive intestinal peptide in the regulation of DOPA (dihydroxyphenylalanine) synthesis. In addition, synergism was found at the level of the accumulation of cyclic adenosine monophosphate, the likely second messenger in the peptidergic regulation of tyrosine hydroxylase activity. The synergism seen with carbachol was blocked by a muscarinic, but not by a nicotinic, antagonist. Synergism was also found between bethanechol, a muscarinic agonist, and secretin, but not between secretin and dimethylphenylpiperazinium, a nicotinic agonist. Since previous immunohistochemical results suggest that vasoactive intestinal peptide and acetylcholine are colocalized in some preganglionic sympathetic neurons, the present data raise the possibility that the two might act synergistically in vivo in regulating catecholamine biosynthesis. Synergistic postsynaptic actions may be a common feature at synapses where peptides of the secretin-glucagon and acetylcholine are colocalized. © 2000 John Wiley & Sons, Inc. J Neurobiol 42: 14–21, 2000
Pathogenic mechanisms of neuronal damage in the AIDS dementia complex. (1997)

It has become clear that infection with HIV-1 is capable of causing a progressive syndrome of neurological disease that is not strictly depend- ent upon the state of immunosuppression in the infected individual.' Although the central nervous system (CNS) is often the target of opportunistic infections in the later stages of AIDS related complex (ARC) or in AIDS itself, the AIDS dementia complex (ADC), or the HIV associated cognitive motor complex as it is otherwise known, is by far the most common cause of neurological dysfunction.2 Neuropsychiatric abnormalities become most prevalent in the late stages of HIV-1 infection, and occur in 40-50% of adults and as many as 70-80% of children with clinically defined AIDS.3 Rarely, the sole indication of HIV-1 infection is the involvement of the CNS.45
Computer-aided design on the VLSI 45/spl deg/-mask compaction (1993)

We combine 1D compaction with reshaping-a new action to improve the result of the compaction. Our algorithms change layout element shapes automatically according to some criteria and make neighboring layout element shapes as similar as possible. The more similar they are, the more compactable space we can obtain. The main part of our compaction is reshaping. If elements of a certain 45/spl deg/ layout can have their geometric shapes reassigned, we reshape them in order to gain a more compactable space. Some experimental results of this 45/spl deg/ compactor with and without reshaping of both Manhattan and nonManhattan 45/spl deg/ layouts are shown. >