gebhart/patrepeval huggingface dataset:
Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma (2007)

Asthma and chronic obstructive pulmonary disease (COPD) are characterized by different patterns of airway remodeling, which all include an increased mass of bronchial smooth muscle (BSM). A remaining major question concerns the mechanisms underlying such a remodeling of BSM. Because mitochondria play a major role in both cell proliferation and apoptosis, we hypothesized that mitochondrial activation in BSM could play a role in this remodeling. We describe that both the mitochondrial mass and oxygen consumption were higher in the BSM from asthmatic subjects than in that from both COPD and controls. This feature, which is specific to asthma, was related to an enhanced mitochondrial biogenesis through up-regulation of peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha, nuclear respiratory factor-1, and mitochondrial transcription factor A. The priming event of such activation was an alteration in BSM calcium homeostasis. BSM cell apoptosis was not different in the three groups of subjects. Asthmatic BSM was, however, characterized by increased cell growth and proliferation. Both characteristics were completely abrogated in mitochondria-deficient asthmatic BSM cells. Conversely, in both COPD and control BSM cells, induction of mitochondrial biogenesis reproduced these characteristics. Thus, BSM in asthmatic patients is characterized by an altered calcium homeostasis that increases mitochondrial biogenesis, which, in turn, enhances cell proliferation, leading to airway remodeling.
Topical corticosteroids in plaque psoriasis: a systematic review of efficacy and treatment modalities (2012)

The clinical development of topical steroids in psoriasis did not follow state of the art modern methodology. Treatment success appears to be highly variable across studies. Maintenance intermittent treatment appears to be useful to prolong remission. Recommendations concerning topical steroids treatment modalities in plaque psoriasis should be mostly based on expert opinion.
Gold Nanoparticle Antibody Conjugates for Use in Competitive Lateral Flow Assays (2012)

Gold nanoparticles (GNPs) are widely used in a variety of biomedical diagnostic assays and for imaging. Their popularity stems from key properties such as their low toxicity and high extinction coefficients, as well as straightforward synthesis methods that allow GNPs to be produced quickly and inexpensively. Here we describe the use of GNPs for visual detection in a lateral flow assay using benzodiazepine affinity assay to illustrate the methods.
Use of Studded Polyflex™ Stents in Patients with Neoplastic Obstructions of the Central Airways (2004)

The studded Polyflex showed excellent efficacy, was very well tolerated, and had a very low migration rate. It presents an improvement over the older smooth model and can be considered a true alternative to the most widely used silastic stent, the Dumon stent.
Biological Control of Tissue Plasminogen Activator-MediatedFibrinolysis (1988)

Fibrinolysis, the body's ability to degrade fibrin, is an integrated part of hemostasis. Overactivity in the fibrinolytic system causes bleeding and underactivity causes thrombosis. Tissue plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1), alpha 2-antiplasmin (alpha 2-AP) and plasminogen are definitely involved in fibrinolysis because: (1) these components can be assigned a fibrinolytic role in purified systems, i.e. in vitro, and (2) abnormal structural variants and abnormal levels of these components give rise to bleeding or to thrombosis. The biological control of tPA-mediated fibrinolysis is both cellular and humoral. The cellular regulation compasses synthesis of tPA and PAI-1 and release/uptake of these components. The humoral regulation involves: (1) the reaction between tPA and PAI-1; (2) the fibrin-stimulated plasminogen activation; (3) the reaction between plasmin and alpha 2-AP and (4) plasmin degradation of fibrin. The highly developed biological control of tPA-mediated fibrinolysis is indicative of its physiological importance.
Tumor Immunotargeting Using Innovative Radionuclides (2015)

This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.
Direct measurement of electric field at line conductors during a.c. corona (1972)

An electrostatic-fluxmeter probe has been used to obtain a direct measurement of the electric field at a cylindrical conductor during a.c. corona. For conductor diameters of 1.59, 2 and 2.75 cm, the resultant electric field falls below the onset level for both positive and negative corona. For the positive discharge, the field becomes independent of the applied voltage, a maximum fall of 9%, being observed. In contrast, the average field in the negative corona discharge decreases with increasing applied voltage, the effective field being reduced by up to 15% of the onset value. The assumption in many theoretical analyses of the discharge that the surface field remains at the onset value is thus invalid. It is suggested that increased secondary ionisation processes account for the maintenance of corona at reduced field strength. The measurements also fail to support the hypothesis that field enhancement occurs during positive corona owing to a negative-ion sheath. Field enhancement is observed to occur in a.c. corona prior to onset, because of remnant space charge from the preceding half cycle, but the effect is small. The field immediately following negative corona extinction is reduced, but, after positive corona, is enhanced because of electron attachment near the anode surface. The method, suitably modified, would appear to offer a useful means of study of bundle-conductor corona and precipitator assemblies of parallel line conductors.
Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection (2011)

A highly complex network of coinhibitory and costimulatory receptors regulates the outcome of virus-specific CD8(+) T-cell responses. Here, we report on the expression patterns of multiple inhibitory receptors on HIV-specific, cytomegalovirus-specific, and bulk CD8(+) T-cell memory populations. In contrast to cytomegalovirus-specific CD8(+) T cells, the majority of HIV-specific CD8(+) T cells exhibited an immature phenotype and expressed Programmed Death-1, CD160 and 2B4 but not lymphocyte activation gene-3. Notably, before antiretroviral therapy, simultaneous expression of these negative regulators correlated strongly with both HIV load and impaired cytokine production. Suppression of HIV replication by antiretroviral therapy was associated with reduced surface expression of inhibitory molecules on HIV-specific CD8(+) T cells. Furthermore, in vitro manipulation of Programmed Death-1 and 2B4 inhibitory pathways increased the proliferative capacity of HIV-specific CD8(+) T cells. Thus, multiple coinhibitory receptors can affect the development of HIV-specific CD8(+) T-cell responses and, by extension, represent potential targets for new immune-based interventions in HIV-infected persons.
Hypercholesterolaemia and its management (2008)

Hypercholesterolaemia is one of the major causes of atherosclerosis. Although there are many causes, hypercholesterolaemia is the permissive factor that allows other risk factors to operate.1 The incidence of coronary heart disease is usually low where population plasma cholesterol concentrations are low.2 In Britain coronary heart disease is a major cause of mortality, and a recent Department of Health survey suggested that the average plasma cholesterol concentration in the United Kingdom was 5.9 mmol/l, much higher than the 4 mmol/l seen in rural China and Japan, where heart disease is uncommon.3 Many studies before and after the introduction of statins have indicated that reducing the prevalence of hypercholesterolaemia is an important means of decreasing coronary risk.

Cholesterol plays an important role as the precursor for steroid hormones and bile acids and it is essential for the structural integrity of cell membranes. It is transported in the body in lipoproteins. Figure 1⇓ shows the role of cholesterol in lipoprotein metabolism.



Fig 1 The role of cholesterol in the metabolism of lipoprotein. Adapted from Charlton-Menys4



Conventionally the upper limit for laboratory reference ranges is based on the 95th or 90th centile for a healthy population. This does not apply to plasma cholesterol, however, as several studies show that the epidemiological relation between plasma cholesterol and risk of coronary heart disease extends to the lower end of the cholesterol distribution. Although the relation becomes progressively steeper, there is no obvious threshold below which it ceases to exist.5 Therefore, it is more rational to base a desirable or healthy concentration of plasma cholesterol on the value at which coronary risk is considered unacceptably high. Most patients developing coronary heart disease have plasma cholesterol concentrations that are likely to be between the 30th and 90th centile for their population …
Functional Expression of <italic>Agrobacterium tumefaciens</italic> T-DNA <italic>onc</italic>-genes in <italic>Asparagus</italic> Crown Gall Tissues (1990)

Journal Article Functional Expression of Agrobacterium tumefaciens T-DNA onc-genes in Asparagus Crown Gall Tissues Get access Els Prinsen, Els Prinsen 1Department of Biology, UIAUniversiteitsplein I, B-2610 Wilrijk, Belgium Search for other works by this author on: Oxford Academic Google Scholar Benny Bytebier, Benny Bytebier 2Laboratorium voor Genetische Virologie, VUBPaardestraat 65 B-1640 St. Genesius-Rode, Belgium Search for other works by this author on: Oxford Academic Google Scholar Jean-Pierre Hernalsteens, Jean-Pierre Hernalsteens 2Laboratorium voor Genetische Virologie, VUBPaardestraat 65 B-1640 St. Genesius-Rode, Belgium Search for other works by this author on: Oxford Academic Google Scholar Jan De Greef, Jan De Greef 1Department of Biology, UIAUniversiteitsplein I, B-2610 Wilrijk, Belgium Search for other works by this author on: Oxford Academic Google Scholar Henri Van Onckelen Henri Van Onckelen 1Department of Biology, UIAUniversiteitsplein I, B-2610 Wilrijk, Belgium Search for other works by this author on: Oxford Academic Google Scholar Plant and Cell Physiology, Volume 31, Issue 1, 1990, Pages 69–75, https://doi.org/10.1093/oxfordjournals.pcp.a077882 Published: 01 January 1990 Article history Received: 07 August 1989 Accepted: 31 October 1989 Published: 01 January 1990
Machine Vision-Based Concrete Surface Quality Assessment (2009)

Manually inspecting concrete surface defects (e.g., cracks and air pockets) is not always reliable. Also, it is labor-intensive. In order to overcome these limitations, automated inspection using image processing techniques was proposed. However, the current work can only detect defects in an image without the ability of evaluating them. This paper presents a novel approach for automatically assessing the impact of two common surface defects (i.e., air pockets and discoloration). These two defects are first located using the developed detection methods. Their attributes, such as the number of air pockets and the area of discoloration regions, are then retrieved to calculate defects’ visual impact ratios (VIRs). The appropriate threshold values for these VIRs are selected through a manual rating survey. This way, for a given concrete surface image, its quality in terms of air pockets and discoloration can be automatically measured by judging whether their VIRs are below the threshold values or not. The method presented in this paper was implemented in C++ and a database of concrete surface images was tested to validate its performance.
Correction: Reprogrammed Transcriptome in Rhesus-Bovine Interspecies Somatic Cell Nuclear Transfer Embryos (2012)

Background: Global activation of the embryonic genome (EGA), one of the most critical steps in early mammalian embryo development, is recognized as the time when interspecies somatic cell nuclear transfer (iSCNT) embryos fail to thrive.
Kinin B2receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice (2008)

Our results suggest that B2 receptors have two major effects in the control of EAE severity: (i) B2 regulates the expression of chemokines, including CCL2 and CCL5, and (ii) B2 modulates leukocyte recruitment and inflammatory lesions in the CNS.
The role of the metal-semiconductor interface in silicon integrated circuit technology (1974)

A typical medium-scale integrated (MSI) circuit requires hundreds of metal-semiconductor (M–S) junctions that are utilized for rectification, interconnection of device elements, and termination to external circuits. Comparison has been made between two metallization technologies, based upon the possible metallurgical reactions with Si: (1) nonreactive, such as evaporated aluminum, and (2) reactive, such as PtSi. Ohmic and rectifying contacts have been contrasted on the basis of the dominant current conduction mechanisms at the M–S interface. Current transport has been characterized in terms of the height and thickness of the potential energy barrier arising from thermal equilibrium among charge carriers between dissimilar conductors. Thermionic emission of electrons and holes provides the first illustration of conduction over a thick potential barrier (≫100 Å), resulting in a rectifying contact (Schottky barrier diode). Thus, Schottky diode currents are exponentially dependent upon potential barrier height and inverse temperature. The contrasting illustration deals with a thin barrier (≪100 Å) that conducts electrons and holes by quantum mechanical tunneling and forms ohmic contacts with resistance controlled only by contact size and underlying silicon resistivity. The final section covers two possible problems associated with silicon integrated circuit (SIC) fabrication. In the first example, a layer of oxide, too thin to be visible by optical interference (&lt;500 Å), can prevent proper contact formation. A method of observation, which makes use of hydrostatic surface tension, has been presented with experimental results on SiO2 films. Successive etching has revealed a detection limit of 11–13 Å. The second deleterious phenomenon to be treated is the electrical degradation of Schottky barrier rectification associated with nonplanar penetration of metals into silicon. The destruction of the planar M–S interface could result from either undesired alloy eutectics or metallic precipitation.
Endovascular brachytherapy: Physics and technology (1998)

Brachytherapy is the placement of radiation sources (usually radioactive materials) in or near a target tissue. This paper introduces the physics and technology needed to perform endovascular brachytherapy. Three main delivery systems under investigation are low activity radioactive stents; high activity solid-sources; and high activity gas or liquid filled balloons. A wide range of radionuclides is under consideration for each of these systems. There are fundamental differences in both the local and long-range distribution of radiation around beta or gamma emitting sources. Devices in the microCi range are permanently implanted. Devices in the mCi range are inserted for a few minutes. Both beta and gamma sources can be extremely dangerous if they are mishandled.
Synthesis of the chromophore of pseudobactin, a fluorescent siderophore from Pseudomonas (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of the chromophore of pseudobactin, a fluorescent siderophore from PseudomonasTeodozyj Kolasa and Marvin J. MillerCite this: J. Org. Chem. 1990, 55, 14, 4246–4255Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/jo00301a008https://doi.org/10.1021/jo00301a008research-articleACS PublicationsRequest reuse permissionsArticle Views1203Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Purification and kinetic parameters of bovine liver N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (1994)

The enzyme N-acetylglucosamine phosphodiester alpha-N-acetylglucosaminidase (phosphodiester alpha-GlcNAcase) catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step by UDP-N-acetyl-glucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase (GlcNAc-phosphotransferase). Phosphodiester alpha-GlcNAcase, a membrane-bound enzyme, has been purified about 3,000-fold from bovine liver to apparent homogeneity using detergent solubilization, fractionation on DEAE-cellulose, affinity chromatography on lectin-Sepharose columns, gel filtration, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The enzyme migrated as 129- and 121-kDa species on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Since both bands had the same amino-terminal sequence, the smaller species is presumed to be derived from the larger by proteolysis. Kinetic analysis of bovine phosphodiester alpha-GlcNAcase with enzymatically synthesized artificial and biological substrates indicates that phosphodiester alpha-GlcNAcase requires GlcNAc-alpha-P R for substrate and that when R contains the Man alpha 1,2Man linkage the substrate binding is most effective. Unlike GlcNAc-phosphotransferase, bovine phosphodiester alpha-GlcNAcase does not require a protein recognition determinant on lysosomal enzyme substrates.
MASSIVE PROSTATIC BLEEDING AFTER TRANSURETHRAL RESECTION OF THE PROSTATE IN A PATIENT WITH A CONGENITAL PELVIC ARTERIOVENOUS MALFORMATION (1998)

No AccessJournal of UrologyClinical Urology: Case Reports1 Nov 1998MASSIVE PROSTATIC BLEEDING AFTER TRANSURETHRAL RESECTION OF THE PROSTATE IN A PATIENT WITH A CONGENITAL PELVIC ARTERIOVENOUS MALFORMATION HIROKAZU TOUYAMA, TADASHI HATANO, and YOSHIHIDE OGAWA HIROKAZU TOUYAMAHIROKAZU TOUYAMA More articles by this author , TADASHI HATANOTADASHI HATANO More articles by this author , and YOSHIHIDE OGAWAYOSHIHIDE OGAWA More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62417-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "MASSIVE PROSTATIC BLEEDING AFTER TRANSURETHRAL RESECTION OF THE PROSTATE IN A PATIENT WITH A CONGENITAL PELVIC ARTERIOVENOUS MALFORMATION." The Journal of Urology, 160(5), p. 1803 References 1 : Congenital pelvic arteriovenous malformation. Urology1986; 27: 165. Google Scholar 2 : Congenital pelvic arteriovenous fistula in a male. A case report. Jap. J. Urol.1992; 83: 243. Google Scholar 3 : Congenital pelvic arteriovenous malformation with massive prostatic hemorrhage: a case report. J. Urol.1989; 141: 382. Link, Google Scholar From the Departments of Urology, Ohama First Hospital and University of the Ryukyus, Okinawa, Japan© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byISHII T, HIGASHIONNA T and HIRATSUKA Y (2018) TRANSRECTAL ULTRASOUND FINDINGS OF PELVIC ARTERIOVENOUS MALFORMATIONJournal of Urology, VOL. 166, NO. 3, (999-999), Online publication date: 1-Sep-2001. Volume 160Issue 5November 1998Page: 1803 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information HIROKAZU TOUYAMA More articles by this author TADASHI HATANO More articles by this author YOSHIHIDE OGAWA More articles by this author Expand All Advertisement PDF downloadLoading ...
Detection of conjugal transfer systems in oral, black-pigmented Bacteroides spp (1990)

Oral, black-pigmented Bacteroides spp. are important pathogens in oral anaerobic infections and dental disease. We detected conjugation systems in isolates of Bacteroides denticola and Bacteroides intermedius that transferred tetracycline resistance (Tetr) and penicillin resistance to Bacteroides buccae and to Bacteroides fragilis, an intestinal Bacteroides species. A cloned Tetr gene from B. fragilis hybridized to the transferable Tetr locus in the oral strains, indicating that genetic exchange occurs between these two groups of anaerobes.
Power Spectral Analysis of Heart Rate Variability in Healthy Young Women During the Normal Menstrual Cycle (1995)

This study investigated the fluctuations of autonomic nervous activities during the menstrual cycle. Twenty college females were tested for cardiovascular reactivity to mental challenge during both follicular and luteal phases across two menstrual cycles. Power spectral analysis of heart rate variability (HRV) was used to examine the autonomic nervous activities. At baseline, although heart rate and blood pressure did not differ across the menstrual cycle, the low-frequency (LF) component in the HRV was higher and the high-frequency (HF) component in the HRV was lower during the luteal phase than during the follicular phase. The LF/HF ratio was also significantly greater in the luteal phase. These data suggest that sympathetic nervous activities are predominant in the luteal phase as compared with follicular phase. In addition, the power spectral analysis of HRV has more sensitivity than heart rate or blood pressure in assessing the slight fluctuations of autonomic nervous activities during the menstrual cycle.
Modeling the cycling degradation of silicon-oxide-nitride-oxide-semiconductor transistors (1992)

A model has been developed to predict cycling-induced threshold voltage shifts of silicon-oxide-nitride-oxide-semiconductor transistors. The model is based on the mechanism of hole transport through the tunnel oxide. It has been experimentally demonstrated that the model accurately predicts cycling behavior for a wide range of cycling parameters. Only two simple experiments are required to determine the model parameters.