gebhart/patrepeval huggingface dataset:
Analysis of dielectric-resonator antennas with emphasis on hemispherical structures (1994)

An overview is given for the development of dielectric-resonator antennas. A detailed analysis and study of the hemispherical structure, excited by a coaxial probe or a slot aperture, is then given, using the dyadic Green's functions pertaining to an electric-current source or a magnetic-current source, located in a dielectric sphere. The integral equation for a hemispherical dielectric-resonator antenna (DRA), excited by either a coaxial probe or a slot aperture, is obtained. The integral equation is solved using the method of moments. The antenna characteristics, such as input impedance, radiation patterns, directivity, and efficiency, are computed numerically, around the resonant frequency of the TE/sub 111/ mode (the HEM/sub 11/ mode for cylindrical coordinates). The computed input impedance is compared with numerical and experimental data available in the literature.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Solubility in the potassium stannate – potassium hydroxide – water system at 0 to 95.0 °C (1968)

Solubilities and phase relations have been determined in the K 2 Sn(OH) 6 –KOH–H 2 O system between 0 and 95.0 °C. The isotherms consist of only one major solubility branch, that of K 2 Sn(OH) 6 , while the solubility branch of KOH is indistinguishable, since the isothermal invariant point is extremely close to the solubility of potassium hydroxide. Solid phases have been determined by Schreinemakers' method and checked with the polarizing microscope.
Defibrotide: An endothelium protecting and stabilizing drug, has an anti-angiogenic potential in vitro and in vivo (2007)

Defibrotide (DF) is a polydisperse mixture of 90% single-stranded oligonucleotides with anti-thrombotic and anti-apoptotic functions. DF is used in the treatment of endothelial complications in the course of allogeneic stem cell transplantation. Recent preclinical evidence suggests that DF might also have anti-neoplastic properties. In the present study we hypothesized that DF might inhibit tumors via an anti-angiogenic effect. The anti-angiogenic potential of DF was tested in vitro using human microvascular endothelial cells forming vessel structures across a layer of dermal fibroblasts. Our results show that pharmacologic DF concentrations (100 mug/ml) significantly reduced vessel formation in this assay. Similarly, DF blocked sprouting from cultured rat aortic rings. In vivo, angiogenesis in a human gastric tumor (TMK1) implanted in dorsal skin-fold chambers (in nude mice) was inhibited by i.v. application of 450 mg/kg DF. Notably, due to its short half-life, DF was most effective when given on a daily basis. Although the precise mechanism of DF remains to be elucidated, initial Western blots show that DF reduces phosphorylation-activation of p70S6 kinase, which is a key target in the PI3K/Akt/mTOR signaling pathway linked to endothelial cell and pericyte proliferation and activation. However, in vitro data suggest that DF acts independently of vascular endothelial growth factor. Taken together, our data suggest that while DF is known for its endothelium-protecting function in SCT, it also inhibits formation of new blood vessels, and thus should be considered for further testing as an adjuvant anti-cancer agent, either alone, or in combination with other drugs.
Carbonic anhydrase IX in bladder cancer (2009)

CAIX was expressed differentially in noninvasive versus invasive tumors, in low-grade versus high-grade bladder cancer, and in primary tumors versus metastases. The current results indicated that CAIX is a strong predictor of recurrence, progression, and overall survival of patients with bladder cancer; and the integration of CAIX expression into conventional prognostic models significantly improved their predictive accuracy. The data suggest a tripartite role of CAIX as a diagnostic, prognostic, and therapeutic molecular marker in bladder cancer.
Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells (2004)

Exosomes are nanovesicles released by leukocytes and epithelial cells. Although their function remains enigmatic, exosomes are a source of antigen and transfer functional major histocompatibility complex (MHC)-I/peptide complexes to dendritic cells (DCs) for CD8(+) T-cell activation. Here we demonstrate that exosomes also are internalized and processed by immature DCs for presentation to CD4(+) T cells. Endocytosed exosomes are sorted into the endocytic compartment of DCs for processing, followed by loading of exosome-derived peptides in MHC-II molecules for presentation to CD4(+) T cells. Targeting of exosomes to DCs is mediated via milk fat globule (MFG)-E8/lactadherin, CD11a, CD54, phosphatidylserine, and the tetraspanins CD9 and CD81 on the exosome and alpha(v)/beta(3) integrin, and CD11a and CD54 on the DCs. Circulating exosomes are internalized by DCs and specialized phagocytes of the spleen and by hepatic Kupffer cells. Internalization of blood-borne allogeneic exosomes by splenic DCs does not affect DC maturation and is followed by loading of the exosome-derived allopeptide IEalpha(52-68) in IA(b) by host CD8alpha(+) DCs for presentation to CD4(+) T cells. These data imply that exosomes present in circulation or extracellular fluids constitute an alternative source of self- or allopeptides for DCs during maintenance of peripheral tolerance or initiation of the indirect pathway of allorecognition in transplantation.
Effect of 5-Fluorouracil, Mitoxantrone, Methotrexate, and Vincristine on the Antibacterial Activity of Ceftriaxone, Ceftazidime, Cefotiam, Piperacillin, and Netilmicin (1986)

Using the checkerboard agar dilution technique, antibacterial activity and in vitro interactions of 4 antineoplastic agents and 5 antimicrobial drugs were examined against 56 strains of 7 bacterial species. 5-fluorouracil was found to inhibit all strains of Staphylococcus aureus and of Staphylococcus epidermidis at a concentration of 0.8 micrograms/ml or less. 84% of all gram-negative strains were inhibited synergistically when 5-fluorouracil was combined with beta-lactam antibiotics. Methotrexate and cefotiam were antagonistic in 42% of all combinations, especially when tested against Escherichia coli and Klebsiella pneumoniae.
Methyl tert‐butyl ether degradation in the unsaturated zone and the relation between MTBE in the atmosphere and shallow groundwater (2001)

Atmospheric methyl tert‐butyl ether (MTBE) concentrations in southern New Jersey generally exceeded concentrations in samples taken from the unsaturated zone. A simple unsaturated zone transport model indicates that MTBE degradation can explain the attenuation with half‐lives from a few months to a couple of years. Tert‐butyl alcohol (TBA), a possible degradation product of MTBE, was detected in unsaturated‐zone samples at concentrations exceeding atmospheric levels at some sites, suggesting the possible conversion of MTBE to TBA. At sites where MTBE was detected in shallow groundwater, the concentration was typically higher than the overlying unsaturated‐zone concentration. This observation is consistent with outgassing from the aquifer and combined with the unsaturated‐zone attenuation suggests some of the MTBE detections in shallow groundwater are nonatmospheric in origin, coming from leaking tanks, road runoff, or other sources. The identification of sources of MTBE in groundwater and attenuation mechanisms through the hydrologic cycle is critical in developing an understanding of the long‐term effect of MTBE releases.
An in situ dissolved‐hydrogen probe for monitoring anaerobic digesters under overload conditions (1995)

The concentration of diatomic hydrogen in the liquid phase of an anaerobic digester was used to determine the onset of digester failure induced by substrate overloading. The construction of an inexpensive probe to measure dissolved hydrogen, having a partial pressure detection limit of 30 Pa, is described. An increase in the partial pressure of dissolved hydrogen, from less than 30 Pa to 400 Pa, was observed when the D-glucose concentration in a laboratory-scaled digester was increased rapidly to 10 mM. However, when the digester was gradually overloaded, an increase in the dissolved-hydrogen partial pressure was not observed until after the digester failed. The accumulation of volatile fatty acids and digester failure were observed at dissolved-hydrogen partial pressures below 30 Pa. (c) 1995 John Wiley & Sons, Inc.
Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor. (1995)

The ability of malignant cells to form metastases in secondary sites remains a major obstacle to the curative treatment of cancer. Previously, we identified type 1 insulin-like growth factor (IGF-1) as a paracrine mitogen for highly metastatic murine carcinoma, H-59 cells. Here the role of IGF-1 and its receptor (IGF-1R) in metastasis was further investigated using H-59 cells transfected with a plasmid vector expressing IGF-1R cDNA in the antisense orientation. The transfectants had a markedly reduced expression of IGF-1R and lost the ability to respond to IGF-1 in vitro. When injected in vivo, either directly into the microvasculature of the liver or lung (experimental metastasis) or s.c. to allow the growth of primary local tumors (spontaneous metastasis), these cells did not give rise to any metastases under conditions which allowed wild-type or control transfectants to form multiple hepatic and pulmonary metastases. The results demonstrate that the IGF-1R can play a critical role in the regulation of carcinoma metastasis.
Automatic Traffic Signs and Panels Inspection System Using Computer Vision (2011)

Computer vision techniques applied to systems used on road maintenance, which are related either to traffic signs or to the road itself, are playing a major role in many countries because of the higher investment on public works of this kind. These systems are able to collect a wide range of information automatically and quickly, with the aim of improving road safety. In this context, the correct visibility of traffic signs and panels is vital for the safety of drivers. This paper describes an approach to the VISUAL Inspection of Signs and panEls (“VISUALISE”), which is an automatic inspection system, mounted onboard a vehicle, which performs inspection tasks at conventional driving speeds. VISUALISE allows for an improvement in the awareness of the road signaling state, supporting planning and decision making on the administration's and infrastructure operators' side. A description of the main computer vision techniques and some experimental results obtained from thousands of kilometers are presented. Finally, the conclusions of the system are described.
Role of Growth Factors in Oncogenesis: Growth Factor‐Proto‐Oncogene Pathways of Mitogenesis (1985)

Cellular genes which encode proteins involved in the response of cells to stimulation by growth factors may be potential oncogenes. The factors involved in the signal transmission from growth factor-receptor interaction to DNA synthesis constitute a cascade system which we call the 'growth factor-proto-oncogene pathway(s) of mitogenesis'. For each growth factor, all the responsive cells, regardless of cell types and tissue source, have specific growth factor receptors which are similar, if not identical, in molecular weight and biological activity. Thus, we believe that the growth factor-proto-oncogene pathway(s) functions in the same manner in all responsive cells. Platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and brain-derived growth factor (BDGF) are major growth factors for connective tissue cells and do not share a common pathway in mitogenesis in responsive cells. The gene product of c-myc may be involved in the cellular response of cells stimulated by PDGF or FGF, but not directly in the signal transmission which leads to DNA synthesis.
Phosphorus-31 NMR kinetic studies of the intra- and intermolecular alkylation chemistry of phosphoramide mustard and cognate N-phosphorylated derivatives of N,N-bis(2-chloroethyl)amine (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphorus-31 NMR kinetic studies of the intra- and intermolecular alkylation chemistry of phosphoramide mustard and cognate N-phosphorylated derivatives of N,N-bis(2-chloroethyl)amineThomas W. Engle, Gerald Zon, and William EganCite this: J. Med. Chem. 1982, 25, 11, 1347–1357Publication Date (Print):November 1, 1982Publication History Published online1 May 2002Published inissue 1 November 1982https://pubs.acs.org/doi/10.1021/jm00353a015https://doi.org/10.1021/jm00353a015research-articleACS PublicationsRequest reuse permissionsArticle Views266Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dual-Source Transfer-Function Generalized Sidelobe Canceller (2008)

Full-duplex hands-free man/machine interface often suffers from directional nonstationary interference, such as a competing speaker, as well as stationary interferences which may comprise both directional and nondirectional signals. The transfer-function generalized sidelobe canceller (TF-GSC) exploits the nonstationarity of the speech signal to enhance it when the undesired interfering signals are stationary. Unfortunately, the assumptions leading to the derivation of the TF-GSC are violated when a nonstationary interference is present. In this paper, we propose an adaptive beamformer, based on the TF-GSC, that is suitable for cancelling nonstationary interferences in noisy reverberant environments. We modify two of the TF-GSC components to enable suppression of the nonstationary undesired signal. A modified fixed beamformer (FBF) is designed to block the nonstationary interfering signal while maintaining the desired speech signal. A modified blocking matrix (BM) is designed to block both the desired signal and the nonstationary interference. We introduce a novel method for updating the blocking matrix in double talk scenarios, which exploits the nonstationarity of both the desired and interfering speech signals. Experimental results demonstrate the performance of the proposed algorithm in noisy and reverberant environments and show its superiority over the original TF-GSC.
Dynamic analysis of ventricular repolarization duration from 24-hour Holter recordings (1993)

Evaluation of the influence of the autonomic nervous system on the ventricular repolarization duration was carried out using beat-to-beat analysis of the time intervals between the peaks of the R and T waves (RTm). After pre-processing of digitized Holter ECG's, auto and cross spectrum analyses were applied to heart rate and repolarization duration variability signals. Coherence analysis was used to assess the existence of common spectral contributions. The heart rate variability signal was used as reference of the sympatho-vagal balance at the sinus node. It was found that, in normal individuals, the autonomic nervous system directly influences the ventricular repolarization duration and that this influence is qualitatively very similar to the one that modulates the heart rate. Pathological alteration of these parallel autonomic activities to the heart (on the sinus node and on the ventricle) might cause uncoupling between depolarization and repolarization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Effect of Reduced Gravity on the Kinematics of Human Walking: A Test of the Dynamic Similarity Hypothesis for Locomotion (1997)

To gain insight into the basic principles that govern the biomechanics of locomotion, we investigated the effect of reduced gravity on walking kinematics. We hypothesized that humans walk in a dynamically similar fashion at combinations of speed and simulated gravity that provide equal values of the Froude number, v2/gLleg, where v is forward speed, g is gravitational acceleration and Lleg is leg length. The Froude number has been used to predict the kinematics and kinetics of legged locomotion over a wide range of animal sizes and speeds, and thus provides a potentially unifying theory for the combined effects of speed, size and gravity on locomotion biomechanics. The occurrence of dynamic similarity at equal Froude numbers has been attributed previously to the importance of gravitational forces in determining locomotion mechanics. We simulated reduced gravity using a device that applies a nearly constant upward force to the torso while subjects walked on a treadmill. We found that at equal Froude numbers, under different levels of gravity (0.25g-1.0g), the subjects walked with nearly the same duty factor (ratio of contact time to stride time), but with relative stride lengths (Ls/Lleg, where Ls is stride length) that differed by as much as 67 %, resulting in the rejection of our hypothesis. To understand the separate effects of speed and gravity further, we compared the mechanics of walking at the same absolute speed at different levels of gravity (0.25g-1.0g). In lower gravity, subjects walked with lower duty factors (10 %) and shorter relative stride lengths (16 %). These modest changes in response to the fourfold change in gravity indicate that factors other than gravitational forces are the primary determinants of walking biomechanics.
Study of Soybean Culture and Analysis on the Chemical Composition of Soybean for Making Use of the Mountainous Uncultivated Land (1976)

This study was undertaken to learn the over-all influence of fertilizer on soybean culture and the chemical composition of soybean in the reclaimed land. Treatments included five rates of N.P.K: 4.10.8, compost: 1, 000. N.P.K.: 4.10.8 + compost: 1, 000, N.P.K: 2.5.5 kg/10 are as well as unfertilized plot in the reclaimed land and N.P.K: 4.10.8 kg/10 are as a check plot of the cultivated area. The yield of green plant above-ground, grain yield and protein content were higher in the cultivated plot than in the reclaimed land. Maximum yield of green plant or the greatest grain yield occurred in the plot of N.P.K: 4.10.8+compost: 1, 000 kg application and they diminished as the fertilizer application decreased. Yet there was no statistical significance in the chemical seed composition among treatments.
Viscosity of Liquids under High Pressures (1990)

By using Pak's theory of liquid, a phenomenological theory of viscosity proposed by the authors is applied to liquids under high pressures. The calculated viscosities for various simple substances are in good agreements with those of the observed values over wide pressure ranges.
Succinct representation of balanced parentheses, static trees and planar graphs (2002)

We consider the implementation of abstract data types for the static objects: binary tree, rooted ordered tree and balanced parenthesis expression. Our representations use an amount of space within a lower order term of the information theoretic minimum and support, in constant time, a richer set of navigational operations than has previously been considered in similar work. In the case of binary trees, for instance, we can move from a node to its left or right child or to the parent in constant time while retaining knowledge of the size of the subtree at which we are positioned. The approach is applied to produce succinct representation of planar graphs in which one can test adjacency in constant time.
The Impact of Consanguinity Worldwide (1998)

Consanguineous marriages have been practiced for hundreds of years in many parts of the world. The rate of congenital malformations among the offspring is 2.5 times higher than that among the offspring of unrelated parents, mainly due to the expression of autosomal-recessive disorders, and hospitalization for these reasons causes a major financial burden. An increase in sterility and in the rates of abortion, stillbirths, perinatal losses and neonatal deaths has been reported by some authors but not by others. It is generally accepted that the advantages of consanguinity outweigh the disadvantages; however, strategies for reducing the burden require a unique approach as discussed in this article.
Retorting Oil Shale by Microwave Power (1979)

Shale oil and a fuel gas have been produced by microwave-heating oil shale in a standard microwave oven in conjunction with experimentation to develop an in situ microwave retorting process. Various grades of oil shale have been subjected to high microwave fields. The derived oil has been submitted to various physical and chemical testing methods, and the chemical composition of the evolved gas has been evaluated. The specific gravity; pour point; yields of oil, water, gas, and losses; and spent shale are compared with parallel data obtained with the Fischer assay procedure. Important differences in oil flow properties and gas composition are discussed in view of microwave interactive theory.
Synthesis, Structure, and Electrochemical Behavior of Li[Ni[sub x]Li[sub 1/3−2x/3]Mn[sub 2/3−x/3]]O[sub 2] (2002)

The synthesis, structure, and electrochemical performance of for is presented. is prepared by substituting for and in while maintaining all the remaining Mn in the +4 oxidation state. Samples with 1/4, 1/3, 5/12, and 1/2 have been investigated by X-ray diffraction (XRD) and neutron diffraction as well as by electrochemical measurements. The XRD and neutron diffraction patterns of (0 < x ⩽ 1/2) show that these compounds adopt the -type structure when synthesized at 800°C and higher. XRD and neutron diffraction also suggest a short-range superlattice ordering of Li, Ni, and Mn in the transition-metal layer for many of the samples. When synthesized at 700°C and lower, the compounds (for x = 1/3 and 1/2) appear to adopt a spinel-type structure like Electrochemical studies show that (900°C) with x = 5/12 can deliver a stable capacity of about 160 mAh/g between 3.0 and 4.4 V vs. Li. An irreversible plateau is observed at about 4.5 V during the first charge of cells (x = 1/6, 1/4, 1/3, and 5/12), which we believe corresponds to the simultaneous removal of lithium and oxygen from the structure. After the plateau, cells with x = 1/3 and 5/12 can deliver stable reversible capacities of about 230 and 225 mAh/g between 2.0 and 4.6 V. (0 < x ⩽ 1/2) synthesized at low temperatures (i.e., 600 and 700°C) shows dramatically different differential capacity vs. voltage behavior compared to the high temperature samples, which must be related to the structural differences between materials prepared above and below 750°C. © 2002 The Electrochemical Society. All rights reserved.