gebhart/patrepeval huggingface dataset:
Insulin-like Growth Factor Receptor Levels Are Regulated by Cell Density and by Long Term Estrogen Deprivation in MCF7 Human Breast Cancer Cells (2001)

This work describes a reciprocal relationship between cell density and levels of insulin-like growth factor receptors (IGFR) in MCF7 human breast cancer cells, which adds a new dimension to the mechanism of cross-talk between estrogen and insulin-like growth factors in the regulation of breast cancer cell growth. The reduced binding of both (125)I-IGF1 and alphaIR3 anti-IGFR antibody to whole cells showed that IGFR are lost from the surface of MCF7 cells as cell density increases, and this occurred irrespective of the presence or absence of estradiol. Western immunoblotting further confirmed loss of type I IGFR from MCF7 cells with increasing cell density. Long term estrogen deprivation was found to increase the levels of IGFR at all cell densities, such that after 96 weeks of estrogen deprivation, IGFR levels had become similar at the highest cell density in the absence of estradiol to the IGFR levels at the lowest cell density in the estrogen-maintained cells, and the levels of IGFR could be increased still further by estradiol. This overexpression of IGFR in the estrogen-deprived cells correlated with a reversal of response to exogenously added ligand, in that concentrations of insulin, IGFI, and IGFII that had stimulated growth of the estrogen-maintained cells became growth inhibitory to the estrogen-deprived cells. Blockade of the IGFIR with the alphaIR3 anti-IGFR antibody could partially inhibit the growth of the estrogen-deprived cells, suggesting that up-regulation of IGFR in these cells may contribute to the mechanism of adaptation to growth in steroid-deprived conditions which results in progression to estrogen independence of cell growth.
Failure Detection and Membership Management in Grid Environments (2005)

Failure detectors are an integral part of any fault tolerant distributed system and hence have been a well-studied area. However, earlier proposed failure detectors fail to perform efficiently when applied to grid environments. Most of the earlier proposed detectors were either designed for local area networks or to handle small number of nodes and hence lack in areas such as scalability, efficiency, running times etc. In this paper we propose a highly scalable failure detector protocol that is aided by a membership management service. The membership management service is essential to make the failure detector transparent to changes in the system. Using a distributed heartbeat mechanism, for an unreliable failure detector, we have overcome the shortcomings of similar schemes proposed earlier. It realizes scalability by reducing context switching requirements and achieves faster failure detection. The membership management protocol handles membership issues with a worst case complexity of O(n) where n is the number of heartbeat groups. Note that n is much smaller than the total number of nodes in the grid. The algorithm is also shown to be failure resilient and scalable.
Mechanisms of Mammalian Iron Homeostasis (2012)

Iron is vital for almost all organisms because of its ability to donate and accept electrons with relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen and energy metabolism, as well as for several other essential processes. Mammalian cells utilize multiple mechanisms to acquire iron. Disruption of iron homeostasis is associated with various human diseases: iron deficiency resulting from defects in the acquisition or distribution of the metal causes anemia, whereas iron surfeit resulting from excessive iron absorption or defective utilization causes abnormal tissue iron deposition, leading to oxidative damage. Mammals utilize distinct mechanisms to regulate iron homeostasis at the systemic and cellular levels. These involve the hormone hepcidin and iron regulatory proteins, which collectively ensure iron balance. This review outlines recent advances in iron regulatory pathways as well as in mechanisms underlying intracellular iron trafficking, an important but less studied area of mammalian iron homeostasis.
A Randomized Trial of Icatibant in ACE-Inhibitor–Induced Angioedema (2015)

Among patients with ACE-inhibitor-induced angioedema, the time to complete resolution of edema was significantly shorter with icatibant than with combination therapy with a glucocorticoid and an antihistamine. (Funded by Shire and the Federal Ministry of Education and Research of Germany; ClinicalTrials.gov number, NCT01154361.).
No evidence for XMRV association in pediatric idiopathic diseases in France (2010)

Retroviruses have been linked to a variety of diseases such as neoplastic and immunodeficiency disorders and neurologic and respiratory diseases. Recently, a novel infectious human retrovirus, the xenotropic murine leukemia virus-related virus (XMRV), has been identified in cohorts of patients with either a familial type of prostate cancer or chronic fatigue syndrome. The apparent unrelatedness of these diseases raised the question of the potential involvement of XMRV in other diseases.Here, we investigated the presence of XMRV in a selection of pediatric idiopathic infectious diseases with symptoms that are suggestive of a retroviral infection, as well as in children with respiratory diseases and in adult patients with spondyloarthritis (SpA). Using a XMRV env-nested PCR, we screened 72 DNA samples obtained from 62 children hospitalized in the Montpellier university hospital (France) for hematological, neurological or inflammatory pathologies, 80 DNA samples from nasopharyngeal aspirates from children with respiratory diseases and 19 DNA samples from SpA. None of the samples tested was positive for XMRV or MLV-like env sequences, indicating that XMRV is not involved in these pathologies.
Exploiting unlabeled data in ensemble methods (2002)

An adaptive semi-supervised ensemble method, ASSEMBLE, is proposed that constructs classification ensembles based on both labeled and unlabeled data. ASSEMBLE alternates between assigning "pseudo-classes" to the unlabeled data using the existing ensemble and constructing the next base classifier using both the labeled and pseudolabeled data. Mathematically, this intuitive algorithm corresponds to maximizing the classification margin in hypothesis space as measured on both the labeled and unlabeled of data. Unlike alternative approaches, ASSEMBLE does not require a semi-supervised learning method for the base classifier. ASSEMBLE can be used in conjunction with any cost-sensitive classification algorithm for both two-class and multi-class problems. ASSEMBLE using decision trees won the NIPS 2001 Unlabeled Data Competition. In addition, strong results on several benchmark datasets using both decision trees and neural networks support the proposed method.
Preparation and Functional Properties of Linseed Protein Products Containing Differing Levels of Mucilage (1988)

ABSTRACT The functionality of two high‐mucilage protein concentrates (HMPC) prepared from linseed and linseed expeller cake by extracting and coprecipitating the mucilage with protein was compared with those of a low‐mucilage flour (LMF), a protein concentrate (LMPC), and a protein isolate (LMPI) in simple systems. The HMPC samples had better water absorption and emulsifying properties, higher foaming capacity, but lower nitrogen solubility, oil absorption, and foam stability than LMF and LMPC. They also registered higher values of viscosity and emulsification characteristics than LMPI.
Frankfurt EBIS development: Fundamental research and new applications (1994)

Fundamental questions of electron beam ion sources (EBIS) are studied using three different setups. Cryogenic classical EBIS: The limit of ion–ion cooling in EBIS devices operating near the space-charge neutralization limit has been studied experimentally. To investigate different degrees of compensation of the electron beam by highly charged ions, a hemispherical analyzer has been constructed including a novel deceleration optic for high resolution. Using its energy definition we tested different modes of ion transportation in our multipassage magnetic spectrometer, which can be operated chromatically as well as extremely dispersively: up to 200 passages could be obtained. EBIS without magnetic field: First results on ion production in the short trap at the very dense crossover of an electron beam (XEBIS) confined only inertially without the use of magnetic fields are presented. Normal conducting short EBIS: Using a normal conducting field of 0.8 T of 25-cm length an EBIS is under construction to study extremely short ion extraction of approximately 4 μs for single turn injection into a medical synchrotron for cancer therapy (MEDEBIS).
Improvement of the Transfer Efficiency of the Atomized Powder Coating System by Increasing the Conveying Air Speed (2009)

This paper deals with improvement of the transfer efficiency of powder coating by increasing the conveying air speed using the atomized powder coating (APC) system. In addition, the details of the powder-mass-flow-rate sensor, which forms the basis of the APC system and realizes sensor-based full automatic control of the system, are described. Usually, for most of the conventional powder coating systems, the conveying air of approximately 80 L/min has been recommended as the empirical standard to avoid decreasing the transfer efficiency and to specifically prevent blowing off a part of the powders deposited on the object. By contrast, for the APC system, the coating thickness in the recessed area was clearly increased with the increase of the volume of the conveying air. Thus, the increase of the volume of the conveying air from 80 to 120 L/min has yielded a 13% increase in the average coating thickness. Such an increase in the coating thickness can be ascribed to the increase of charge density on the powder particles sprayed from the gun.
Casuariin, stachyurin and strictinin, new ellagitannins from Casuarina stricta and Stachyurus praecox. (1982)

Three new ellagitannins, casuariin (5), stachyurin (6) and strictinin (7) have been isolated from Casuarina stricta, and their structures elucidated. Of these, 5 and 6 were found to be C-glucosidic tannins. All of the ellagitannins (1-7) isolated from C. stricta have been found also in Stachyurus praecox.
Self-deflection of laser beams in a thin nonlinear film (1988)

The self-deflection of slab laser beams with right-triangular and semi-Gaussian intensity profiles that pass through a thin nonlinear film are compared, and semi-Gaussian beam profiles are found to produce near-maximum self-deflection angles. We also analyze symmetric profiles (both triangular and Gaussian), which, instead of self-(de)focusing, exhibit strongly counter-self-deflected beams in the far-field region. This evidence indicates that the self-deflection effect can dominate over self-focusing.
Shear-wave Splitting Analysis of Microearthquake Data Observed with Downhole Seismic Network (2008)

This paper presents a semi-automatic method to analyse shear-wave splitting of microearthquakes. The rotation-correlation method, co-variance matrix method, aspect ratio method and the measure of polarization strength are combined to provide a stable estimate of a semi-automatic estimation of the shear-wave splitting parameters, namely rotation angle of the fast direction and the delay time. The method is then applied to microearthquakes that have been recorded with deep borehole seismometers in the San Andreas Fault Observatory at Depth in combination with data from the High Resolution Seismic Network. Both networks are borehole installations and the sampling rates are relatively high (4000 Hz and 250 Hz, respectively). The abundance of microearthquakes in the magnitude ranges from about -2 to 2 and the good coverage of high quality seismic stations makes it possible to map the anisotropy with respect to the ray paths between sources and receivers. Preliminary results already show significant differences of shear-wave splitting delay times in some areas of the network.
Guided wave diffraction tomography within the born approximation (2010)

Detection and sizing of corrosion in pipelines and pressure vessels over large, partially accessible areas is of growing interest in the petrochemical industry. Low-frequency guided wave diffraction tomography is a potentially attractive technique to rapidly evaluate the thickness of large sections of partially accessible structures. Finite element simulations of a 64-element circular array on a plate show that when the scattering mechanism of the object to be reconstructed satisfies the Born approximation, the reconstruction of the thickness is accurate. However, the practical implementation is more challenging because the incident field is not known. This paper describes the baseline subtraction approach commonly used in structural health monitoring applications and proposes a new approach in which the measurement of the incident field is not required when using a circular array of transducers. Experimental results demonstrate that ultimately the scattering from the array of transducers is a major source of error in the tomographic reconstruction, but when there is no scattering from the array of transducers the reconstructions are very similar to the finite element simulations.
Hypoxia-Induced increase in FDG uptake in MCF7 cells. (2001)

The hypoxia-induced increase in 3H-FDG uptake in MCF7 cells is the result, in part, of an increase in glucose transporter activity resulting from the modification (reduction) of thiol group(s) in the glucose transport protein(s). Modulation of hexokinase activity is probably not involved in the hypoxia-induced increase in 3H-FDG uptake in these cells.
<p>Graphene-Based Nanoparticles as Potential Treatment Options for Parkinson’s Disease: A Molecular Dynamics Study</p> (2020)

Ultimately, it was concluded that N-Graphene could be the most effective monolayer to disrupt amyloid fibrillation, and consequently, prevent the progression of Parkinson's disease.
Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours (2008)

DKK3 mRNA expression and consequently DKK3 protein expression become frequently downregulated during human breast cancer development due to aberrant methylation of the DKK3 promoter. Since DKK3 is thought to negatively regulate oncogenic Wnt signalling, DKK3 may be a potential tumour suppressor gene in normal breast tissue.
Production of Holograms with Incoherent Illumination (1966)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text H. R. Worthington, "Production of Holograms with Incoherent Illumination," J. Opt. Soc. Am. 56, 1397-1398 (1966) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
TNF-related apoptosis inducing ligand (TRAIL) enhances TCR-mediated renal cancer recognition by a novel CD4+ T cell clone (50.29) (2007)

Abstract A human CD4+ T cell clone (HC/2G-1) was established by stimulating peripheral blood T cells with dendritic cells pre-incubated with the autologous apoptotic renal tumor line in the presence of IFN-α. It recognizes multiple MHC-mismatched RCCs by IFN-γ release (10 of 11 lines) and lysis (9 of 10 lines), but does not recognize multiple EBV-B cells or fibroblasts. It shows little or no recognition of a panel of melanomas, breast cancer and non-small cell lung cancers. Phenotypically, HC/2G-1 is CD3+CD4+TCRα/β+, but CD161−CD16−NKG2D−. HC/2G-1 does not utilize Vα or Vβ TCRs described for classical NKT cells, but rather Vα14, Vβ2.1. Tumor recognition was TCR α/β mediated as demonstrated by conferring reactivity by transducing third party T-cells with the cloned TCR from HC/2G-1. Tumor recognition by clone HC/2G-1 was not blocked by antibodies to HLA-class I or class II, but was significantly reduced by both anti-TCRα/β and anti-TRAIL Ab. HC/2G-1 expresses low level of TRAIL, and can be upregulated with type I IFNs. Although most RCC tumor lines were resistant to TRAIL induced apoptosis, treatment of soluble TRAIL trimer enhances tumor recognition such as IFN-γ production by HC/2G-1 as well as by HC/2G-1 TCR-transduced T cells. Furthermore, tumor recognition by HC/2G-1 TCR-transduced T cells was blocked by anti-TRAIL Ab. This suggests that TRAIL may be inducing the antigen, or a restriction element on tumor cells. Attempts to understand the molecular mechanism of tumor recognition by HC/2G-1 are underway.
Expression of Prostasome-like Granules by the Prostate Cancer Cell Lines PC3, Dul45 and LnCaP Grown in Monolayer (1999)

Prostasomes are a granular type of secretory product in the human prostate gland cells. It is not known, whether in vitro grown cells derived from human prostate cancers also express prostate secretory components containing granules with properties similar to the prostasomes. Therefore, we carried out the present investigation and found that cytospins of in vitro grown PC3, DU145 and LNCaP cells generally expressed a granular secretion. DU145 demonstrated the highest ratio of cells with granules (about 90%), while cytospins of PC3 and LNCaP contained less stained cells (50-70%). Purified granules from PC3 cells were immunoreactive with a monoclonal antibody (mAb78) originally raised against human seminal prostasomes. The PC3 granules also shared the property with human seminal prostasomes having an elevated UV260/UV280 absorbance ratio. On the other hand we found a low aminopeptidase activity in PC3 granules contrary to that of human prostasomes. Prostasomes may form a heterogeneous group with different properties due to the source from which they are isolated and perhaps it is justified to recognize them as different members of a prostasome family.
Analysis of Property of Ultimate States of Steel Truss Road and Rail CableStayed Bridges (2009)

Take a long span truss rail and road cable-stayed bridge as the example,using nonlinear finite element method,properties of the truss rail and road cable stayed bridge under load ultimate limit state and serviceability limit state are studied.Two different methods to calculate the initial stress of the cable were adopted: one is concerned with safety factor and partial load factors and the other is unconcerned with these factors.Dynamic characteristics of the truss rail and road cable-stayed bridge were studied and static responses of the bridge under basic loads combination and long-term effect loads combination were calculated respectively.Based on comaprative study,the initial cable stress had great effect on vertical members and cables.In addition,the influence of the initial cable stress on dynamic properties of cable-stayed bridges was little and can be neglected.The result showed that truss rail.and road cable-stayed bridges having the initial cable stress which was calculated by considering the safety and partial loads factors had more rasonable statuses and better mechanical behavious.
Fatores de risco e proteção para doenças crônicas não transmissíveis entre beneficiários da saúde suplementar: resultados do inquérito telefônico Vigitel, Brasil, 2008 (2011)

This article aims at estimating the prevalence of adults engaging in protective and risk health behaviors among members of private health insurance plans. It was used a random sample of individuals over the age of 18 living in the Brazilian state capitals collected on 28,640 telephone interviews in 2008. The results showed that among males there was a high prevalence of the following risk factors: tobacco, overweight, low fruit and vegetable consumption, high meat with fat consumption and alcohol drinking. Among females we found a high prevalence of high blood pressure, diabetes, dyslipidemia and osteoporosis. Men were generally more physically active and women consumed more fruit and vegetables. As more educated males were lower was the prevalence of tobacco, high blood pressure, but also a higher prevalence of overweight, consumption of meat with fat, dyslipidemia and lower number of yearly check-ups done. For females, tobacco smoking, overweight, obesity, decreasing with schooling, and consumption of fruit and vegetables, physical activity, mammography and PAP test, increased with schooling. The health insurance user population constitutes about 26% of Brazilian people and the current study aims to accumulate evidence for health promotion actions by this public.
Joint imaging by teleseismic converted and multiple waves and its application in the INDEPTH‐III passive seismic array (2005)

A joint imaging by teleseismic converted and multiple phases is put forward to image the crustal structure beneath the INDEPTH‐III passive seismic profile in the central Tibet. A depth dependent Vp/Vs ratio is adopted to map common conversion point (CCP) via a Vp/Vs scanning and stacking approach. Our new crustal image shows that the crust is divided into two sections with different Moho depth distributions and amplitudes, with the boundary nearby the Bangong‐Nujiang suture (BNS). A negative P‐to‐S amplitude band is located in the upper‐to‐middle crust, indicating a low velocity zone possibly caused by partial melting beneath the negative amplitude band. The average crustal Vp/Vs ratio estimated by our joint imaging method is higher than previous study, but is consistent with a partial melting middle‐to‐lower crust implied by many other results.
Allergic contact dermatitis to cocamidopropylbetaine in hair shampoo (1998)

Allergic contact dermatitis to shampoo is rare. Report of a patient with widespread dermatitis caused by contact allergy to Kathon CG and cocamidopropylbetaine in shampoo used is presented.
Potential for evolution of California serogroup bunyaviruses by genome reassortment in Aedes albopictus. (1999)

Aedes albopictus was introduced into the United States in used tires in 1985. Its successful colonization of the upper Midwest has potential to alter the current epidemiology of bunyaviruses that circulate in the region. It is permissive for the replication of several arboviruses, including La Crosse (LACV) and Jamestown Canyon (JCV) bunyaviruses. In this study, we demonstrate the ability of LACV and JCV to coinfect Ae. albopictus mosquitoes and to form all six possible reassortant genotypes. All reassortant viruses infect Ae. albopictus orally and can be transmitted to suckling mice. All reassortants are neurovirulent in mice. However, reassortant viruses carrying the LACV M segment in the foreign genetic background of JCV are more neuroinvasive than JCV, or any other reassortant genotype. In addition, these reassortants can replicate in gerbils and infect Ae. triseriatus, characteristics of LACV, but not JCV. Because Ae. albopictus is spreading into new geographic areas and feeds on a variety of mammals, including humans, it has the potential to transmit new, emerging bunyaviruses in nature.
Electrical characterization of SOI substrates incorporating WSi/sub x/ ground planes (2005)

Silicon-on-insulator (SOI) substrates incorporating tungsten silicide ground planes (GPs) have been shown to offer the lowest reported crosstalk figure of merit for application in mixed signal integrated circuits. The inclusion of the silicide layer in the structure may lead to stress or defects in the overlying SOI layers and resultant degradation of device performance. It is therefore essential to establish the quality of the silicon on the GPSOI substrate. MOS capacitor structures have been employed in this paper to characterize these GPSOI substrates for the first time. High quality MOS capacitor characteristics have been achieved with minority carrier lifetime of /spl sim/0.8 ms. These results show that the substrate is suitable for device manufacture with no degradation in the silicon due to stress or metallic contamination resulting from the inclusion of the underlying silicide layer.