gebhart/patrepeval huggingface dataset:
FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo (2011)

We examined in vivo FLT3 inhibition in acute myeloid leukemia patients treated with chemotherapy followed by the FLT3 inhibitor lestaurtinib, comparing newly diagnosed acute myeloid leukemia patients with relapsed patients. Because we noted that in vivo FLT3 inhibition by lestaurtinib was less effective in the relapsed patients compared with the newly diagnosed patients, we investigated whether plasma FLT3 ligand (FL) levels could influence the efficacy of FLT3 inhibition in these patients. After intensive chemotherapy, FL levels rose to a mean of 488 pg/mL on day 15 of induction therapy for newly diagnosed patients, whereas they rose to a mean of 1148 pg/mL in the relapsed patients. FL levels rose even higher with successive courses of chemotherapy, to a mean of 3251 pg/mL after the fourth course. In vitro, exogenous FL at concentrations similar to those observed in patients mitigated FLT3 inhibition and cytotoxicity for each of 5 different FLT3 inhibitors (lestaurtinib, midostaurin, sorafenib, KW-2449, and AC220). The dramatic increase in FL level after chemotherapy represents a possible obstacle to inhibiting FLT3 in this clinical setting. These findings could have important implications regarding the design and outcome of trials of FLT3 inhibitors and furthermore suggest a rationale for targeting FL as a therapeutic strategy.
Les Mamelles de Tirésias : résumé (2000)

Les Mamelles de Tirésias nous montre une femme, nommée Thérèse, qui quitte le domaine conjugal : histoire très moderne car, en Europe, en cas de divorce, ce sont majoritairement les femmes qui cherchent à partir. En l’occurrence, la révolte de Thérèse est déclenchée par la présence pesante d’un mari autoritaire qui n’a d’autre conversation que la phrase « Donnez-moi du lard » : animal primaire, il ne veut que nourriture et progéniture (des « lardons »). Confronté à une épouse insoumise, au dé...
Carbon Emissions, Renewable Electricity, and Profits: Comparing Policies to Promote Anaerobic Digesters on Dairies (2012)

Anaerobic digesters can provide renewable energy and reduce greenhouse gas emissions from manure management. Government policies that encourage digester adoption by livestock operations include construction cost-share grants, renewable electricity subsidies, and carbon pricing (offset) programs. However, the effectiveness and efficiency of these policies is not well understood. For the U.S. dairy sector, we compare predicted digester adoption rates, carbon emission reductions, renewable electricity generation and sales, and net returns and social benefits of several policies. We find that a carbon pricing policy provides the greatest net social benefit for a range of assumptions about the benefits of carbon reductions and renewable energy.
Cervical cancer. (2000)

Cervical cancer is the second most common type of cancer in women worldwide, after breast cancer. A preponderance of evidence supports a causal link between human papillomavirus infection and cervical neoplasia. The presence of high-risk human papillomavirus genital subtypes increases the risk of malignant transformation. Widespread use of the Papanicolaou smear has dramatically reduced the incidence of cervical cancer in developed countries. Accurate and early recognition of abnormal cytologic changes prevents progression of the disease from preinvasive to invasive. Research is under way to determine if efforts to reduce the false-negative rate of the Papanicolaou smear should include rescreening programs and fluid-based technology. Once cervical cancer is diagnosed, clinical staging takes place. Early-stage tumors can be managed with cone biopsy or simple hysterectomy. Higher stage tumors can be treated surgically or with radiotherapy. Advanced metastatic disease may respond to radiation therapy and concurrent chemotherapy. Protein markers for detection of recurrence and vaccines for prevention of cervical cancer are under investigation.
A 0.25 μm CMOS technology with 45 Å NO-nitrided oxide (2002)

This paper describes the device design and fabrication of a 0.25 /spl mu/m CMOS process integrated with 45 /spl Aring/ oxynitride gate dielectric for high-performance logic applications. Channel profile engineering is applied to control short-channel effects. With TiN-capped Co salicide, the gate sheet resistance is reduced to less than 5 /spl Omega//sq at 0.18 /spl mu/m. Ring oscillator gate delay of 26 ps/stage is accomplished at a supply voltage of 1.8 V.
Structural and magnetic properties and tunnel magnetoresistance for Co<sub>2</sub>(Cr,Fe)Al and Co<sub>2</sub>FeSi full-Heusler alloys (2006)

We have investigated the structure and magnetization of Co2(Cr1−xFex)Al (0 ≤ x ≤ 1) and Co2FeSi full-Heusler alloy films deposited on thermally oxidized Si (SiO2) and MgO (001) single crystal substrates by ultra-high vacuum sputtering at various temperatures. The films were also post-annealed after deposition at room temperature (RT). Magnetic tunnel junctions with a full-Huesler alloy electrode were fabricated with a stacking structure of Co2YZ (20 nm)/Al (1.2 nm)-oxide/Co75Fe25 (3 nm)/IrMn (15 nm)/Ta (60 nm) and microfabricated using electron beam lithography and Ar ion etching with a 102 µm2 junction area, where Co2YZ stands for Co2(Cr1−xFex)Al or Co2FeSi. The tunnel barriers were formed by the deposition of 1.2 nm Al, followed by plasma oxidization in the chamber. The x-ray diffraction revealed the A2 or B2 structure depending on heat treatment conditions and the substrate, but not L21 structure for the Co2(Cr1−xFex)Al (0 ≤ x ≤ 1) films. The L21 structure, however, was obtained for the Co2FeSi films when deposited on a MgO (001) substrate at elevated temperatures above 473 K. The maximum tunnelling magnetoresistance (TMR) was obtained with 52% at RT and 83% at 5 K for a junction using a Co2(Cr0.4Fe0.6)Al electrode. While the junction using a Co2FeSi electrode with the L21 structure exhibited the TMR of 41% at RT and 60% at 5 K, which may be improved by using a buffer layer for reducing the lattice misfit between the Co2FeSi and MgO (001) substrate.
Methylation‐specific PCR for detection of neoplastic DNA in biopsy washings (2002)

Epigenetic DNA alterations such as promoter hypermethylation of glutathione S-transferase P1 (GSTP1) in prostatic adenocarcinoma frequently constitute tumour biomarkers. Neoplastic transformation was identified in washings of prostate biopsies by GSTP1 promoter hypermethylation, using methylation-specific PCR (MSP). Twenty-six patients undergoing sextant transrectal prostate biopsies for clinically suspected prostate cancer were enrolled. All ten patients diagnosed with adenocarcinoma (100%) and four of six patients with prostatic intraepithelial neoplasia (67%), but none of ten patients with benign hyperplasia (0%), exhibited GSTP1 promoter hypermethylation in at least one out of six biopsy washings. Since this approach is transferable to various cancer entities, a sensitive and specific DNA-based analysis of biopsy material seems generally feasible without impeding routine histopathological examination.
Capacitation of mouse spermatozoa: II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway (1995)

In the accompanying report (Visconti, P.E., Bailey, J.L., Moore, G.D., Pan, D., Olds-Clarke, P. and Kopf, G.S. (1995) Development, 121, 1129-1137) we demonstrated that the tyrosine phosphorylation of a subset of mouse sperm proteins of M(r) 40,000-120,000 was correlated with the capacitation state of the sperm. The mechanism by which protein tyrosine phosphorylation is regulated in sperm during this process is the subject of this report. Cauda epididymal sperm, when incubated in media devoid of NaHCO3, CaCl2 or bovine serum albumin do not display the capacitation-associated increases in protein tyrosine phosphorylation of this subset of proteins. This NaHCO3, CaCl2 or bovine serum albumin requirement for protein tyrosine phosphorylation can be completely overcome by the addition of biologically active, but not inactive, cAMP analogues. Addition of the active cAMP analogues to sperm incubated in media devoid of NaHCO3, CaCl2 or bovine serum albumin overcomes the inability of these media to support capacitation, as assessed by the ability of the cells to acquire the pattern B chlortetracycline fluorescence, to undergo the zona pellucida-induced acrosome reaction and, in some cases, to fertilize metaphase II-arrested eggs in vitro. The effects of the cAMP analogues to enhance protein tyrosine phosphorylation and to promote capacitation appears to be at the level of the cAMP-dependent protein kinase (PKA), since two specific inhibitors of this enzyme (H-89 and Rp-cAMPS) block the capacitation-dependent increases in protein tyrosine phosphorylation in sperm incubated in media supporting capacitation. Capacitation, as assessed by the aforementioned endpoints, also appears to be inhibited by H-89 in a concentration-dependent manner. These results provide further evidence for the interrelationship between protein tyrosine phosphorylation and the appearance of the capacitated state in mouse sperm. They also demonstrate that both protein tyrosine phosphorylation and capacitation appear to be regulated by cAMP/PKA. Up-regulation of protein tyrosine phosphorylation by cAMP/PKA in sperm is, to our knowledge, the first demonstration of such an interrelationship between tyrosine kinase/phosphatase and PKA signaling pathways.
Some amino-alkylmagnesium complexes: evidence for three-co-ordinate magnesium (1967)

Dimethylamine yields the insoluble presumed polymeric amide [(Me2N)2Mg]x on reaction with diethylmagnesium in 1 : 1 molar ratio. Diethyl- and di-isopropyl-amine yield ethylmagnesium derivatives, (EtMgNR2)n, from which ether or tetrahydrofuran could not be separated. Insoluble, evidently polymeric, ether-free products, (EtMgNPh2)x and (PriMgNPh2)x are formed from diphenylamine, and crystalline bis-ether complexes of these are also described. Di-isopropylmagnesium gives a dimeric product, (PriMgNPri2)2, on reaction with di-isopropylamine. Similar crystalline dimers are formed from diethylmagnesium and 2,2,6,6-tetramethylpiperidine, and by the addition of diethylmagnesium to benzylideneaniline.Di-isopropylmagnesium forms a crystalline t-butyl cyanide complex, (Pr2iMg·NCBut), whereas diethylmagnesium adds to t-butyl and to phenyl cyanide giving products containing azomethine bonds.
Inactivation of the Osteopontin Gene Enhances Vascular Calcification of Matrix Gla Protein–deficient Mice (2002)

Osteopontin (OPN) is abundantly expressed in human calcified arteries. To examine the role of OPN in vascular calcification, OPN mutant mice were crossed with matrix Gla protein (MGP) mutant mice. Mice deficient in MGP alone (MGP(-/-) OPN(+/+)) showed calcification of their arteries as early as 2 weeks (wk) after birth (0.33 +/- 0.01 mmol/g dry weight), and the expression of OPN in the calcified arteries was greatly up-regulated compared with MGP wild-types. OPN accumulated adjacent to the mineral and colocalized to surrounding cells in the calcified media. Cells synthesizing OPN lacked smooth muscle (SM) lineage markers, SM alpha-actin and SM22alpha. However, most of them were not macrophages. Importantly, mice deficient in both MGP and OPN had twice as much arterial calcification as MGP(-/-) OPN(+/+) at 2 wk, and over 3 times as much at 4 wk, suggesting an inhibitory effect of OPN in vascular calcification. Moreover, these mice died significantly earlier (4.4 +/- 0.2 wk) than MGP(-/-) OPN(+/+) counterparts (6.6 +/- 1.0 wk). The cause of death in these animals was found to be vascular rupture followed by hemorrhage, most likely due to enhanced calcification. These studies are the first to demonstrate a role for OPN as an inducible inhibitor of ectopic calcification in vivo.
Purging in autologous and allogeneic bone marrow transplantation (1992)

The success of hematoablative dosages of cytotoxic therapy followed by stem cell transplantation depends on the disease response to the intensive drug dose and the ability of the transplant to provide durable hematopoietic reconstitution. In autologous stem cell transplantation, patients' own bone marrow or peripheral blood is used for hematopoietic engraftment. In several diseases the bone marrow is involved, and in such situations, the success of autologous stem cell transplantation may improve if the hematopoietic elements are enriched (positive selection) or if the contaminating cancer cells are purged by negative selection. In patients undergoing allogeneic bone marrow transplantation, the T lymphocytes of the donor cells contribute to the development of graft-versus-host disease with significant morbidity and mortality. Selective purging of T lymphocytes has dramatically decreased the incidence of graft-versus-host disease. In this paper, various methods for purging hematopoietic stem cells are detailed with emphasis on treatment planning. Exciting new possibilities include growing stem cells from a small amount of bone marrow, enhancing immune surveillance, and decreasing drug resistance by genetic engineering.
Kinodynamically Consistent Motion Retargeting for Humanoids (2015)

Human-to-humanoid motion retargeting is an important tool to generate human-like humanoid motions. This retargeting problem is often formulated as a Cartesian control problem for the humanoid from a set of task points in the captured human data. Classically, Cartesian control has been developed for redundant systems. While redundancy fundamentally adds new sub-task capabilities, the degree to which secondary objectives can be faithfully executed cannot be determined in advance. In fact, a robot that exhibits redundancy with respect to an operational task may have insufficient degrees of freedom (DOFs) to satisfy more critical constraints. In this paper, we present a Cartesian space resolved acceleration control framework to handle execution of operational tasks and constraints for redundant and nonredundant task specifications. The approach is well suited for online control of humanoid robots from captured human motion data expressed by Cartesian variables. The current formulation enforces kinematic constraints such as joint limits, self-collisions, and foot constraints and incorporates a dynamically-consistent redundancy resolution approach to minimize costly joint motions. The efficacy of the proposed algorithm is demonstrated by simulated and real-time experiments of human motion replication on a Honda humanoid robot model. The algorithm closely tracks all input motions while smoothly and automatically transitioning between regimes where different constraints are binding.
From uncertainty to visual exploration (2002)

The question posed is what can be inferred from ambiguity in processes of visual interpretation? Much emphasis is naturally placed on the form of constraints used to minimize ambiguity, particularly as they pertain to such issues as perceptual acceptability. The authors feel that it is perhaps more instructive to consider what can be learned from situations where different interpretations of data are possible, i.e., the ambiguity of perception. This immediately raises a number of issues regarding the characterization of ambiguity, communicating it to other visual processes, and using ambiguity to further refine visual interpretation. The context in which the authors discuss these problems is the interpretation of scene geometry in the form of volumetric models. They describe a representation for ambiguity in terms of an ellipsoid of confidence in which there is a finite probability that the true parameters of the model can be found.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Fast Algorithm to Reduce Gibbs Ringing Artifact in MRI (2005)

In magnetic resonance imaging, a finite number of k-space data are often collected in order to decrease the acquisition time. The partial k-space data lead to the famous Gibbs ringing artifact with Fourier transform method. The Gegenbauer reconstruction method has been shown to effectively eliminate the Gibbs ringing artifact and restore high resolution. However, the disadvantages of using the Gegenbauer method are more computational time and complicated the choice of parameters. In this paper, we improve the Gegenbauer method by introducing the inverse polynomial reconstruction method and replacing the Gegenbauer polynomials with the Chebyshev polynomials. The new method effectively reduces the reconstructed error and computational cost without any requirement for selection of parameters. Additionally, we present an improved edge detection method which can achieve more accurate edge and make our new reconstruction method more efficient. The proposed method is verified with experiment of the artifact removal.
Design and test‐bed implementation of a reconfigurable receiver for navigation applications (2002)

Abstract The geographical location of a wireless device is acquiring a significant importance under the boost of innovative applications in the wireless market, and under the research activities related to the development of a new generation of Global Navigation Satellite Systems (GNSS). In the US a new phase of the Global Positioning System is foreseen, and Europe has decided to proceed with the Galileo program. In addition, different government institutions worldwide are working toward the definition of navigation plans , and regulations will set as mandatory the location identification of mobile users in emergency situations (US E‐911 law and the European E‐112 directive). Considering all the navigation/positioning systems and techniques that will be available in the near future, it is clear that a central role will be played by the user handset; in fact, if navigation signals from different sources will be available, the unique possibility to obtain the best navigation performance from the user perspective will be the employment of enhanced receivers able to fuse different data. With this aim, this paper presents the design of an innovative navigation receiver based on Software Defined Radio (SDR) technology. The reconfigurability and flexibility issues are guaranteed by the use of reprogrammable high‐speed hardware (FPGA—Field Programmable Gate Array and DSP—Digital Signal Processor) and thus a deep integration at the raw signal level between GPS and the future Galileo has been obtained. The interoperability issue among different systems is then solved at the receiver level. This paper discusses the implementation of a baseline architecture of a reconfigurable GNSS receiver over a FPGA + DSP prototype platform. The receiver is able to deal with different input Signals‐In‐Space (SIS), and can operate with present GPS ranging signals or with the future Galileo SIS. Copyright © 2002 John Wiley & Sons, Ltd.
Differential Phosphorylation of c-Jun and JunD in Response to the Epidermal Growth Factor Is Determined by the Structure of MAPK Targeting Sequences (2004)

MAPK phosphorylation of various substrates is mediated by the presence of docking sites, including the D domain and the DEF motif. Depending on the number and sequences of these domains, substrates are phosphorylated by specific subsets of MAPKs. For example, a D domain targets JNK to c-Jun, whereas a DEF motif is required for ERK phosphorylation of c-Fos. JunD, in contrast, contains both D and DEF domains. Here we show that these motifs mediate JunD phosphorylation in response to either ERK or JNK activation. An intact D domain is required for phosphorylation and activation of JunD by both subtypes of MAPK. The DEF motif acts together with the D domain to elicit efficient phosphorylation of JunD in response to the epidermal growth factor (EGF) but has no function on JunD phosphorylation and activation by JNK signaling. Furthermore, we show that conversion of a c-Jun sequence to a canonical DEF domain, as it is present in JunD, elicits c-Jun activation in response to EGF. Our results suggest that evolution of a particular modular system of MAPK targeting sequences has determined a differential response of JunD and c-Jun to ERK activation.
3D-LaneNet: End-to-End 3D Multiple Lane Detection (2018)

We introduce a network that directly predicts the 3D layout of lanes in a road scene from a single image. This work marks a first attempt to address this task with on-board sensing without assuming a known constant lane width or relying on pre-mapped environments. Our network architecture, 3D-LaneNet, applies two new concepts: intra-network inverse-perspective mapping (IPM) and anchor-based lane representation. The intra-network IPM projection facilitates a dual-representation information flow in both regular image-view and top-view. An anchor-per-column output representation enables our end-to-end approach which replaces common heuristics such as clustering and outlier rejection, casting lane estimation as an object detection problem. In addition, our approach explicitly handles complex situations such as lane merges and splits. Results are shown on two new 3D lane datasets, a synthetic and a real one. For comparison with existing methods, we test our approach on the image-only tuSimple lane detection benchmark, achieving performance competitive with state-of-the-art.
Industrial and Engineering Chemistry Editorials (1940)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTIndustrial and Engineering Chemistry EditorialsHarrison E. HoweCite this: Ind. Eng. Chem. 1940, 32, 9, 1149–1150Publication Date (Print):September 1, 1940Publication History Published online1 May 2002Published inissue 1 September 1940https://pubs.acs.org/doi/10.1021/ie50369a001https://doi.org/10.1021/ie50369a001research-articleACS PublicationsRequest reuse permissionsArticle Views12Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Clinical guidelines for the treatment of depressive disorders. IV. Medications and other biological treatments. (2001)

There is significant evidence to support the role of selective serotonin reuptake inhibitors (SSRIs), novel agents, and classic agents in the treatment of major depressive disorder (MDD). There is also evidence to support the use of somatic treatments, including ECT and light therapy, for some patients with MDD. There is limited evidence for the use of specific medications to treat subtypes of MDD. There is emerging evidence to support augmentation and combination strategies for patients previously nonresponsive to medication.