gebhart/patrepeval huggingface dataset:
DNMT3A mutation leads to leukemic extramedullary infiltration mediated by TWIST1 (2016)

Our results demonstrate that D3Amut in OCI-AML3 strain enhances leukemic aggressiveness by promoting EMI process, which is partially through upregulating TWIST1.
Experimental and theoretical analysis of shadow-masked growth using organometallic vapor-phase epitaxy: The reason for the absence of facetting (1995)

Shadow-masked growth using organometallic vapor-phase epitaxy allows the creation of nonplanar regions having smoothly varying profiles devoid of macroscopic facets. The shape of these profiles is independent of gas flow direction and stripe orientation, suggesting that they are determined by lateral gas phase gradients. It is proposed that the absence of facets is due to the unique growth regime underneath the shadow mask, where organic radicals combine with group-III surface species, temporarily returning them to the vapor phase. This process has been simulated using a two-dimensional finite-element analysis that accurately describes the experimental behavior. Furthermore, this hypothesis predicts other experimentally observed phenomena.
Monolithic integration of GaAs-waveguide optical intensity modulator with MESFET drive electronics (1992)

A high-performance GaAs electro-optic waveguide modulator with monolithically integrated MESFET drive electronics is reported. High-contrast (30:1) optical intensity modulation at λ = 1.15μm is achieved for an input voltage swing of 0.26 V in a low-loss 8mm-electrode Mach-Zehnder device driven by an on-chip MESFET amplifier.
Supply Chain Systems—Recent Trend in Research and Applications (2011)

Supply chains consist of a number of autonomous companies that make decision independently. In this paper applications of various system approaches from theoretical to implementation issues of supply chain systems are discussed. This special section is a collection of original re search that addresses various aspects of supply chain systems design, implementation, and applications.
Hot filament enhanced chemical vapor deposition of AlN thin films (1991)

Hot filament enhanced chemical vapor deposition of aluminum nitride thin films from trimethylaluminum and ammonia has been investigated for deposition temperatures ranging from 584 to 732 K. The use of a hot filament resulted in an approximate two orders of magnitude increase in the deposition rate compared to a similar, uncatalyzed growth. The film deposition rate and refractive index did not depend on the substrate temperature. X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy indicated that the films were high purity aluminum nitride, with negligible carbon and oxygen contamination.
Quantitation of free and hydrolyzable phenolic acids in seeds by capillary gas-liquid chromatography (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitation of free and hydrolyzable phenolic acids in seeds by capillary gas-liquid chromatographyKazimierz J. Dabrowski and Frank W. SosulskiCite this: J. Agric. Food Chem. 1984, 32, 1, 123–127Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://pubs.acs.org/doi/10.1021/jf00121a031https://doi.org/10.1021/jf00121a031research-articleACS PublicationsRequest reuse permissionsArticle Views211Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Undergraduate Student Cheating in the Fields of Business and Economics (1997)

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsClifford NowellClifford Nowell is an associate professor of economics at Weber State University. Doug Laufer is a professor of accounting at Metro State University, Denver. The authors thank Lisa Crone. Rick Crosser, Jim Swearingen, and Sarah Tinkler for their cooperation and comments. The authors are grateful for the suggestions of Joe Kerkvliet, Peter Kennedy, and three anonymous referees.
Computing Skypattern Cubes (2014)

We introduce skypattern cubes and propose an efficient bottom-up approach to compute them. Our approach relies on derivation rules collecting skypatterns of a parent node from its child nodes without any dominance test. Non-derivable skypatterns are computed on the fly thanks to Dynamic CSP. The bottom-up principle enables to provide a concise representation of the cube based on skypattern equivalence classes without any supplementary effort. Experiments show the effectiveness of our proposal.
Reentry of T cells to the adult thymus is restricted to activated T cells. (1991)

To seek information on the capacity of mature T cells to migrate to the thymus, mice were injected with Thy-1-marked populations enriched for resting T cells or T blast cells; localization of the donor cells in the host thymus was assessed by staining cryostat sections of thymus and by FACS analysis of cell suspensions. With injection of purified resting T cells, thymic homing was extremely limited, even with injection of large doses of cells. By contrast, in vivo generated T blast cells migrated to the thymus in substantial numbers. Thymic homing by T blasts was greater than 50-fold more efficient than with resting T cells. Blast cells localized largely in the medulla and remained in the thymus for at least 1 mo post-transfer. Interestingly, localization of T blasts in the thymus was 10-fold higher in irradiated hosts than normal hosts. Thymic homing was especially prominent in mice injected with T blasts incubated in vitro with the DNA precursor, 125I-5-iodo-2'deoxyuridine (125IDUR); with transfer of 125IDUR-labeled blasts to irradiated hosts, up to 5% of the injected counts localized in the host thymus. These data suggest that thymic homing by T blasts might be largely restricted to cells in S phase. The physiological significance of blast cell entry to the thymus is unclear. The possibility that these cells participate in intrathymic tolerance induction is discussed.
Core and valence band photoelectron spectroscopic studies of nickel oxidation in an anaerobic liquid cell (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCore and valence band photoelectron spectroscopic studies of nickel oxidation in an anaerobic liquid cellYuanling. Liang, Dilip K. Paul, Yaoming. Xie, and Peter M. A. SherwoodCite this: Anal. Chem. 1993, 65, 17, 2276–2281Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ac00065a018https://doi.org/10.1021/ac00065a018research-articleACS PublicationsRequest reuse permissionsArticle Views183Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An FIR Implementation of Zero Frequency Filtering of Speech Signals (2012)

Zero frequency filtering is a technique used in the characterization and analysis of glottal activity from speech signals. The filter design originally proposed has an infinite impulse response (IIR) filter followed by two successive finite impulse response (FIR) filters. In this paper, the process of its computation is analyzed and a simplified FIR implementation is proposed by employing the inherent pole-zero cancellation involved in the process. Theoretical proofs are derived in both, frequency and time domains. We show that the theoretically derived FIR filter is a convolution of two filters, whose impulse responses are triangular shaped. The advantage of the proposed FIR filter lies in reduction of computational requirements for zero frequency filtering which include - 1) use of single-precision floating point and 2) stability of the filter.
[Biological evaluation within a risk management process]. (2007)

Bio-evaluation within the medical device quality/risk management system is a risk analyzing and assessing process. On the basis of data from characterization of materials, scientific literatures, application history, bio-toxicology testing and so on, weighing the benefit and the risk, bio-evaluation does a conclusion to "take" or "quit" the product design. There is no "zero risk" though "no toxicity" always is the most desirable conclusion in a testing report. The application history data is the most comprehensive among the information available, since no testing system can "clone" the human body. In addition, the capital cost has to be taken into account when bringing the sophisticated testing technologies into the evaluating system. Investigating the #G95-1 of FDA CDRH and the changes of ISO 10993-1, the trend to integrate bio-evaluation into a quality/risk management process can be figured out.
Taxol, vincristine or nocodazole induces lethality in G1-checkpoint-defective human astrocytoma U373MG cells by triggering hyperploid progression (1999)

In this report, we describe a novel lytic mechanism exploited by antimicrotubule drugs (AMDs) such as Taxol which are frequently used to treat multiple human cancers including breast and ovarian cancers. In cells lacking the G1-arresting capacity due to the defect in retinoblastoma or p53 gene function, AMDs trigger hyperploid progression and death. The hyperploid progression occurs via continued cell-cycle progression without cell division. Blocking hyperploid progression through hydroxyurea or ectopically expressed p27(Kip1), a G1-specific Cdk inhibitor, abrogates AMD cytotoxicity. Thus, AMDs induce lethality in G1-checkpoint-defective cells by triggering hyperploid progression. The phenomenon is reminiscent of that observed previously with bub-1 yeast mutant. The potential significance of this finding lies in that hyperploid progression-mediated death may be exploited to develop a therapy with tumor-specificity at the genetic level. As a large fraction of human cancers are mutated in p53 gene, it may have a wide therapeutic applicability.
Adaptive Transmission With Single-Carrier Multilevel BICM (2007)

In this paper, we introduce adaptive link control techniques for multiple-input multiple-output (MIMO) systems with broadband single-carrier signaling. Soft cancellation and minimum mean squared error turbo equalization is assumed, where matching between coding and equalization plays crucial roles to achieve high throughput. This paper uses multilevel coded bit-interleaved coded modulation (ML-BICM) with linear mapping as a core part of the transmission, on top of which this paper applies automatic repeat request (ARQ) with adaptive coding (AC) for link control. The reason behind the use of the linear mapping ML-BICM is the separability between the layers in the modulation format: This should bring us a significant benefit in designing the link control strategies because each layer has its own reliability, and the adaptive link control should be optimized based on the each layer's reliabilities. For ARQ with ML-BICM, we introduce layer-by-layer retransmission control, where turbo equalization and retransmission control can be performed independently over the layers because of the layer-separability. The layer-by-layer concept is then applied to AC with ML-BICM, where the code parameters such as code rate and generator polynomials are chosen so that after several iterations the mutual information between the transmitted and the soft-input soft-output decoder output information can reach a value very close to one while minimizing the rate loss due to the mismatch between the equalization and decoder. Extrinsic information transfer analysis is performed for the MIMO channel realization being given. The transmitter is notified of the selected codes for the each layer via the feedback channel, and uses the selected codes for the following transmission, assuming that the channel state information (CSI) stays the same at least over two consecutive frames. Finally, this paper evaluates the throughput performances of the ML-BICM ARQ and AC techniques using multidimensional field measurement data. The performance tendencies are correlated with propagation properties, obtained as results of the high-resolution channel analysis, such as spatial spreads at the transmitter and receiver sides.
Karyoplast-cytoplast volume ratio in bovine nuclear transfer embryos: Effect on developmental potential (1997)

To evaluate the effect of karyoplast-cytoplast ratio on the development of nuclear transfer embryos, karyoplasts from day 4, day 5, and day 6 embryos were transferred to oocytes enucleated with different volumes of cytoplasm: Type 1, removal of a small volume of cytoplasm equivalent to the first polar body, Type 2, removal of a volume of cytoplasm approximately equal to the volume of the respective karyoplast, and Type 3, removal of half of the oocyte volume. In addition, the effect of experimental reduction of karyoplast cytoplasm was investigated in day 4 and day 5 karyoplasts. Intact day 4 karyoplasts fused to Type 3 cytoplasts did not support development to blastocysts, whereas these karyoplasts yielded blastocysts in combination with Type 1 (7%) and Type 2 cytoplasts (12%). After experimental reduction of cytoplasmic volume in day 4 karyoplasts, blastocysts (10%) were also obtained after fusion with Type 3 cytoplasts, probably due to reduction of cytoplasmic chimerism. With day 5 karyoplasts, blastocyst rate was higher in combination with Type 2 (34%) than with Type 1 (19%) and Type 3 cytoplasts (16%; P < 0.05). The use of day 6 intact karyoplasts resulted in a significantly (P < 0.05) higher proportion of blastocysts when fused with Type 2 (38%) or Type 1 cytoplasts (34%) than with Type 3 cytoplasts (16%). These results suggest that enucleation of oocytes with a volume similar to that of the respective karyoplast creates better conditions for cell cycle interactions with all types of karyoplasts than enucleation with minimal or large volume of cytoplasm.
Expression profile, clinical significance, and biological function of insulin-like growth factor 2 messenger RNA-binding proteins in non–small cell lung cancer (2017)

Insulin-like growth factor 2 messenger RNA-binding proteins have been described to associate with malignant process in many cancers. However, the role of insulin-like growth factor 2 messenger RNA-binding protein family has not been thoroughly elucidated in non-small cell lung cancer. This study was to investigate the expression profile, clinical significance, and biological function of insulin-like growth factor 2 messenger RNA-binding proteins family in non-small cell lung cancer. The expression levels of IGF2BP1-IGF2BP3 in tumor and adjacent normal tissues were determined, and association with clinicopathological features and overall survival was investigated by analyzing The Cancer Genome Atlas lung cancer database. Proliferation, migration, invasion assays, and flow-cytometry analysis were used to investigate the biological function in vitro. Insulin-like growth factor 2 messenger RNA-binding protein expression levels were significantly increased in non-small cell lung cancer compared to adjacent normal lung tissues. Chi-square test indicated that IGF2BP1 and IGF2BP3 expressions correlated with some meaningful clinical characteristics in non-small cell lung cancer. Kaplan-Meier analysis showed that high-level expression of IGF2BP1 or IGF2BP3 predicted poor overall survival in lung adenocarcinoma patients. Multivariate regression analysis showed that high level of IGF2BP3 was an independent risk factor for poor prognosis in lung adenocarcinoma patients (hazard ratio = 1.616, p = 0.017). In vitro, knockdown of IGF2BP3 inhibited lung adenocarcinoma cell proliferation by inducing cell cycle arrest and apoptosis, and undermined abilities of migration and invasion, and overexpression of IGF2BP3 could promote malignant phenotypes in lung adenocarcinoma cells. Our study revealed that expression of insulin-like growth factor 2 messenger RNA-binding proteins was widely upregulated and correlated with some certain clinicopathological features in non-small cell lung cancer. Especially, in insulin-like growth factor 2 messenger RNA-binding protein family, IGF2BP3 might play the most important role in tumor aggressiveness and prognosis in lung adenocarcinoma, and IGF2BP3 might serve as a potential therapeutic target and a novel prognostic biomarker in lung adenocarcinoma patients.
Total UK multi-centre experience with a novel arterial occlusion device (Duct Occlud pfm). (1996)

This novel detachable coil type occlusion system compares favourably with other methods of transcatheter occlusion of native, residual, or surgically created aortopulmonary shunts. The delivery system allows its use in small children.
On the Design of Virtual Machine Sandboxes for Distributed Computing in Wide-area Overlays of Virtual Workstations (2006)

With recent advances in virtual computing and the revelation that compute-intensive tasks run well on system virtual machines (VMs), the ability to develop, deploy, and manage distributed systems has been ameliorated. This paper explores the design space of VM-based sandboxes where the following techniques that facilitate the deployment of secure nodes in wide-area overlays of virtual workstations (WOWs) are employed: DHCP-based virtual IP address allocation, self-configuring virtual networks supporting peer-to-peer NAT traversal, stacked file systems, and IPsec-based host authentication and end-to-end encryption of communication channels. Experiments with implementations of single-image VM sandboxes, which incorporate the above features and are easily deployable on hosted I/O VMMs, show execution time overheads of 10.6% or less for a batch- oriented CPU-intensive benchmark.
Dual PI3K/mTOR Inhibitor NVP-BEZ235 Sensitizes Docetaxel in Castration Resistant Prostate Cancer (2013)

Results suggest that inhibition of the PI3K/Akt/mTOR signaling pathway by NVP-BEZ235 can overcome docetaxel resistance in human castration resistant prostate cancer. Our findings provide a molecular basis for the clinical use of combined administration of NVP-BEZ235 and docetaxel in patients with castration resistant prostate cancer.
TRANSPORT OF RARE EARTH METAL IONS THROUGH ACTIVATED COMPOSITE MEMBRANES CONTAINING DEHPA (2000)

ABSTRACT This paper reports the results obtained by studying the transport properties of novel highly stable activated composite membranes (ACM) containing di-2-ethylhexyl phosphoric acid as a carrier. ACM samples containing different amount of DEHPA have been prepared by varying the DEHPA concentration in the casting solution. The selectivity of Ho and Pr transport through ACMs has been shown to depend on pH of the feed solution and DEHPA concentration in the membrane. ACM samples with a relatively low carrier content exhibit a higher selectivity for Ho, while an increase of DEHPA concentration in ACM results in the reversal of membrane selectivities. The transport properties of ACM do not change within a week of continuous operation. Additional informationNotes on contributorsMaria Mun¯oz Corresponding author
Synthesis of some newer indazolyl-oxadiazoles, thiadiazoles and 1,2,4-Triazoles (1994)

2-Aryl-3-chloro-2H-indazole (4), obtained in excellent yield (>90%) by the action of thionyl chloride on o-azidobenzanilide(3), was allowed to condense with ethyl p-aminobenzoate to afford the corresponding indazolo-ester (6). This latter compound was converted into a new series of 2-aryl-indazole systems containing the potentially antimicorbial oxadiazole, thiadiazole and 1,2,4-triazole moieties (9,10, 13 & 14). Some of the newly synthesized compounds were tested for biological activity.
Variable orthogonality factor: a simple interface between link and system level simulation for high speed downlink packet access (2003)

Detailed simulations of the full physical layer operation of a cellular network are usually performed in two stages, link level and system level. Emergence of new link adaptation and radio resource management techniques together with need for higher modeling accuracy are blurring the line separating these stages. In this paper we address the issue of performing a link level/system level separation and defining the interface between them for simulating high speed downlink packet access (HSDPA), a part of WCDMA standard. The main challenge is to model frequency selective fading on the system level, while retaining the Rake receiver on the link level. We present available strategies and propose a novel interface based on variable orthogonality factor (OF), which serves as a compact description of the momentary channel impulse response. Finally, we present HSDPA simulation results demonstrating the high accuracy of our approach.
Permutation tests for equality of distributions in high-dimensional settings (2002)

Motivated by applications in high-dimensional settings, we suggest a test of the hypothesis H-0 that two sampled distributions are identical. It is assumed that two independent datasets are drawn from the respective populations, which may be very general. In particular, the distributions may be multivariate or infinite-dimensional, in the latter case representing, for example, the distributions of random functions from one Euclidean space to another. Our test uses a measure of distance between data. This measure should be symmetric but need not satisfy the triangle inequality, so it is not essential that it be a metric. The test is based on ranking the pooled dataset, with respect to the distance and relative to any fixed data value, and repeating this operation for each fixed datum. A permutation argument enables a critical point to be chosen such that the test has concisely known significance level, conditional on the set of all pairwise distances.