gebhart/patrepeval huggingface dataset:
Purification of a novel type of calcium-activated neutral protease from rat brain. Possible involvement in production of the neuropeptide kyotorphin from calpastatin fragments. (1990)

We have found a novel type of Ca2(+)-activated neutral protease in rat brain cytosol which cleaves -Tyr-Arg-containing calpastatin fragments to release the neuropeptide kyotorphin. This enzyme was purified about 26,000-fold by column chromatography as follows: DE52 cellulose, Ultrogel AcA 44, thiopropyl-Sepharose 6B, second DE52 cellulose, Ultrogel AcA 34, and blue Sepharose CL-6B. The molecular mass of the enzyme was estimated to be 65-75 kDa by gel filtration. The purified enzyme gave a single band of 74 kDa by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Some properties of this enzyme were similar to those of the calpains, i.e. an absolute requirement for Ca2+, maximal activity at neutral pH, and inhibition by sulfhydryl reagents such as p-chloromercuriphenylsulfonic acid and N-ethylmaleimide. However, it differs from the calpains in that it possesses no caseinolytic activity, separates from the calpains on the first DE52 column, and is insensitive to leupeptin and E-64 (N-[N-(L-3-trans-carboxyoxrian-2-carbonyl)-L-leucyl]agmatine). Thus, the molecular mass, the substrate specificity, the chromatographic behavior, and the inhibitor spectrum all suggest that this enzyme is a novel type of Ca2(+)-activated neutral protease.
Performance of downlink nulling for combined packet/circuit switched systems (2002)

In the evolution of 2/sup nd/ generation mobile communication systems packet switched data transmission (e.g. GPRS/EGPRS in GSM Phase 2+) and circuit switched speech communication will be demanded in parallel. Directing nulls of the antenna pattern to active mobiles in the downlink beamforming process using antenna arrays at the base station may be useless in the case of packet data transmission. We show that even in combined packet/circuit switched mobile communication systems "gentle" downlink interferer nulling dependent on propagation conditions and traffic distribution leads to performance and capacity improvements.
Invasion and metastasis in pancreatic cancer. (2003)

Pancreatic cancer remains a challenging disease with an overall cumulative 5-year survival rate below 1%. The process of cancer initiation, progression and metastasis is still not understood well. Invasion and tumor metastasis are closely related and both occur within a tumour-host microecology, where stroma and tumour cells exchange enzymes and cytokines that modify the local extracellular matrix, stimulate cell migration, and promote cell proliferation and tumor cell survival. During the last decade considerable progress has been made in understanding genetic alterations of genes involved in local and systemic tumor growth. The most important changes occur in genes which regulate cell cycle progression, extracellular matrix homeostasis and cell migration. Furthermore, there is growing evidence that epigenetic factors including angiogenesis and lymphangiogenesis may participate in the formation of tumor metastasis. In this review we highlight the most important genetic alterations involved in tumor invasion and metastasis and further outline the role of tumor angiogenesis and lymphangiogenesis in systemic tumor dissemination.
Measurement Of Laser Diode Spot Size And Source Astigmatism Using A Phase-Shifting Interferometer (1988)

A phase-shifting Mach-Zehnder interferometer was used to measure wavefront phase errors for an uncollimated laser diode source. The axial separation of the beam waists was then computed from the measured wavefront astigmatism and compared with directly measured values and the manufacturer's specifications. An optical disk head was also measured and the focused spot profile was calculated from the measured wavefront and beam apodization. The calculated profile was then compared with spot size measurements using a knife edge scanner.
World Wide Web Marketing: Integrating the Internet into Your Marketing Strategy (1995)

From the Publisher:
Written for the marketing professional, this book shows how to use the World Wide Web on the Internet to promote products and services and how to create a corporate Web site. Uses screen shots of the latest Web sites to demonstrate what works and what doesn't. Feature interviews with marketing professionals who have extensive experience on the Internet. Includes specific examples of winning techniques which will make a marketing professional successful.
Cation Exchange Properties of Antimonic(V) Acid (1966)

いわゆるアンチモン酸が希薄硫酸リチウム溶液からリチウムイオンを吸着することは古くから知られており,アンチモン酸塩が生成するらしいと考えられていた。五塩化アンチモンの加水分解によってアンチモン酸を調製し,塩素イオンのなくなるまで冷水で洗浄した。この試料を乾燥するとカラム操作に適する塊状物が得られる。この塊状物について,吸着の可逆性を検討した。アンチモン酸へのカリウムイオンの吸着は塩化カリウム溶液の濃度の増加とともに増加し,そのときのpHは吸着したカリウムイオンと等しい当量の水素イオンを遊離するために減少する。吸着したカリウムイオンは硝酸または硝酸アンモニウム溶液によって脱着される。カリウムイオンの分布係数(Rd)は水素イオン濃度[H+]またはアンモニウムイオン濃度[NH4+]によって変化し,そのlog Kdとlog[NH+]またはlog[NH4+]は(-1)の直線関係を示し,二つの1価陽イオン間でイオン交換平衡が成立することがわかった。したがって,このアンチモン酸へのカリウムイオンの吸着-脱着は明らかにイオン交換反応に基づくことがわかった。
Stability Criteria in Non-Equilibrium Thermodynamics (1973)

The following considerations are concerned with transport states, which can be far away from thermal equilibrium. The considerations shall be restricted to transport states which can be described by relatively few macroscopic variables. If these variables are constant in time, they are called steady states.
Managing personal files across independent file management units (1992)

This paper presents the design and implementation of the PFS personal file management system. PFS provides transparent and reliable access to personal files that are dispersed across reliable independent file servers. PFS is unique and practical since it runs on variations of the Unix system, it does not modify the operating system kernel, and more importantly, it operates in environments in which a user lacks administrative control. By means of the PFS, a user creates a global structure of personal files that appear identical despite the server that the user accesses. Since each file is replicated once, the system provides transparent access to files despite one failure at any server. >
Leukemia inhibitory factor protects against experimental lethal Escherichia coli septic shock in mice. (1995)

Leukemia inhibitory factor (LIF) has recently been associated with septic shock in humans. In this study we sought to determine, in mice, the role of LIF in septic shock. During sublethal endotoxemia, serum LIF levels, as determined by radio-receptor competition assay, peaked at 2 h and were low (3 ng/ml), whereas in lethal Escherichia coli septic shock serum LIF levels rose progressively (> 30 ng/ml) in the premorbid phase coincident with the development of tissue injury. Single i.v. injections of high doses (up to 50 micrograms per mouse) of recombinant murine LIF had no obvious acute detrimental effects, whereas continued i.p. administration (30 micrograms per mouse per day) for 3-4 days induced a fatal catabolic state without evidence of preceding hemodynamic collapse or shock. Simultaneous or subsequent administration of high doses of LIF had no effect on mortality from sublethal and lethal E. coli septic shock, whereas prior administration conferred significant protection against lethality (P << 0.001 by log-rank test), an effect that was dose and interval dependent. This protective effect resembled endotoxin tolerance and was characterized by suppression of E. coli-induced serum tumor necrosis factor concentration (P < 0.05), reduction in the number of viable bacteria (P < 0.05), and prevention of sepsis-induced tissue injury. These observations suggest that systemic LIF production is part of the host response to both endotoxin and sepsis-induced tissue injury.
The Research Setting and the Right Not to Be Researched (1973)

The Research Setting and the Right Not to be Researched Get access Edward Sagarin Edward Sagarin City College of the City University of New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Social Problems, Volume 21, Issue 1, Summer 1973, Pages 52–64, https://doi.org/10.2307/799976 Published: 07 August 2014
Comparison of the Neutral Red and Methylene Blue Assays to Study Cell Growth in Culture (1993)

The neutral red and methylene blue in vitro cytotoxicity assays were compared under a variety of conditions using normal human ovarian epithelial cells to determine whether either assay is superior for studying cell growth. The results were standardized against a DNA spectrofluorometric assay. Although the assays were equivalent in reflecting cell number, each has specific advantages: while neutral red discriminates between viable and dead cells, the methylene blue assay is more sensitive and easier to perform.
Guidelines for treatment of onychomycosis (2003)

These guidelines for management of onychomycosis have been prepared for dermatologists on behalf of the British Association of Dermatologists. They present evidence-based guidance for treatment, with identification of the strength of evidence available at the time of preparation of the guidelines, and a brief overview of epidemiological aspects, diagnosis and investigation.
Silent mutations in the phenylalanine hydroxylase gene as an aid to the diagnosis of phenylketonuria. (1991)

Direct sequencing of the phenylalanine hydroxylase (PAH) gene indicated the existence of silent mutations in codons 232, 245, and 385, linked to specific RFLP haplotypes in several Caucasian populations, namely Germans, Bulgarians, Italians, Turks, and Lithuanians. All three mutations create a new restriction site and can be easily detected on PCR amplified DNA. The usefulness of the silent mutations for diagnostic purposes depends on the haplotype distribution in the target population. The combined analysis of these markers and one or two PKU mutations forms a simple panel of diagnostic tests with full informativeness in a large proportion of PKU families, which helps to avoid the problems of genetic heterogeneity and of prenatal genomic Southern blot analysis.
Alpha and Theta EEG in Vigilance (1967)

During a 1-hr. vigilance session Ss were required to detect specified digit triads in an uninterrupted random digit series. EEG was recorded continuously with sampled epochs analyzed by computer for autocorrelation and period analysis. Correlogram ratios indicated progressively decreasing arousal through the session but did not distinguish responses from detection failures. Incidence of alpha waves by period analysis also did not identify errors, but incidence of theta waves dropped significantly just prior to failures and did not do so around responses.
100 MHz, 20 V, 90% efficient synchronous buck converter with integrated gate driver (2014)

This paper describes a synchronous buck converter based on a GaN-on-SiC integrated circuit, which includes a halfbridge power stage, as well as a modified active pull-up gate driver stage. The integrated modified active pull-up driver takes advantage of depletion-mode device characteristics to achieve fast switching with low power consumption. Design principles and results are presented for a synchronous buck converter prototype operating at 100 MHz switching frequency, delivering up to 7 W from 20 V input voltage. Measured power-stage efficiency peaks above 91%, and remains above 85% over a wide range of operating conditions. Experimental results show that the converter has the ability to accurately track a 20 MHz bandwidth LTE envelope signal with 83.7% efficiency.
Regional Citrate Anticoagulation for Hemodialysis in the Patient at High Risk for Bleeding (1983)

CONVENTIONAL hemodialysis requires heparin anticoagulation to prevent clotting in the dialysis assembly. Hemodialysis of the patient who is at high risk for hemorrhage is complicated by a 10 to 30 per cent incidence of bleeding, which results from systemic anticoagulation.1 2 3 4 5 6 7 Alternatives to conventional heparin anticoagulation that are designed to reduce bleeding complications during hemodialysis include limited-dose heparinization,1 , 2 neutralization of heparin with protamine,2 , 3 prostacyclin infusion,4 , 5 and non-anticoagulant high-flow-rate hemodialysis.6 , 7 Although the incidence of bleeding complications has been reduced, each of these methods has its own limitations or complications.1 2 3 4 5 6 7 We have developed a unique method using sodium citrate as the sole anticoagulant. . . .
Transgenic mice containing growth hormone fusion genes (1984)

New genes composed of the mouse metallothionein I promoter-regulator and the rat or human growth hormone structural gene have been introduced into mice. A large proportion of mice containing these genes express them, and some animals grow to be up to twice as large as controls. The technique has been used in part to correct the genetic defect that results in the small stature of the mutant little mouse.
The effect of withdrawing antihypertensive therapy: a review (1988)

In this report the effects of withdrawing antihypertensive medication are reviewed from case reports and randomized trials. Success, defined as the proportion of patients remaining normotensive after withdrawal of medication varied from 15% to over 50%. Factors that predicted the return of high blood pressure after withdrawal, however, included high level of pre-treated blood pressure, marked obesity, short duration of treatment and left ventricular hypertrophy (LVH). Male patients also tended to be more likely to return to having high blood pressure than female patients. In community studies, it is predicted that many subjects will not be suitable candidates for withdrawal or treatment in view of their high blood pressures (both treated and pre-treated), obesity, and also their unwillingness to stop therapy.
Electrical characterization of band gap states in C-doped TiO2 films (2005)

We report on band gap states in C-doped TiO2 films that were prepared by oxidative annealing of sputtered TiC films at 550°C in flowing O2 gas. Deep-level optical spectroscopy measurements revealed three deep levels located at ∼0.86, ∼1.30, and ∼2.34eV below the conduction band. The first level is probably attributable to the intrinsic nature of TiO2, whereas the latter two levels are newly introduced by the C-doping. In particular, the pronounced 2.34eV band contributes to band gap narrowing by mixing with the O 2p valence band. Additionally, the 0.86 and 1.30eV levels can be active as an efficient generation-recombination center.
LT TTT - A Flexible Tokenisation Tool (2000)

We describe LT TTT, a recently developed software system which provides tools to perform text tokenisation and mark-up. The system includes ready-made components to segment text into paragraphs, sentences, words and other kinds of token but, crucially, it also allows users to tailor rule-sets to produce mark-up appropriate for particular applications. We present three case studies of our use of LT TTT: named-entity recognition (MUC-7), citation recognition and mark-up and the preparation of a corpus in the medical domain. We conclude with a discussion of the use of browsers to visualise marked-up text. 1. Introduction The LTG&apos;s Text Tokenisation Toolkit (LT TTT, Grover et al., 1999) was developed within an XML processing paradigm whereby tools are combined together in a pipeline allowing each to add, modify or remove some piece of mark-up. The tools are compatible with the LT XML toolset (Thompson et al., 1997) and use the LT XML API to manipulate attribute values and character data ...
A Compute Capable SSD Architecture for Next-Generation Non-volatile Memories (2014)

Existing storage technologies (e.g., disks and ash) are failing to cope with the processor and main memory speed and are limiting the overall perfor- mance of many large scale I/O or data-intensive applications. Emerging fast byte-addressable non-volatile memory (NVM) technologies, such as phase-change memory (PCM), spin-transfer torque memory (STTM) and memristor are very promising and are approaching DRAM-like performance with lower power con- sumption and higher density as process technology scales. These new memories are narrowing down the performance gap between the storage and the main mem- ory and are putting forward challenging problems on existing SSD architecture, I/O interface (e.g, SATA, PCIe) and software. This dissertation addresses those challenges and presents a novel SSD architecture called XSSD. XSSD o oads com- putation in storage to exploit fast NVMs and reduce the redundant data tra c across the I/O bus. XSSD o ers a exible RPC-based programming framework that developers can use for application development on SSD without dealing with the complication of the underlying architecture and communication management. We have built a prototype of XSSD on the BEE3 FPGA prototyping system. We implement various data-intensive applications and achieve speedup and energy ef- ciency of 1.5-8.9 and 1.7-10.27 respectively. This dissertation also compares XSSD with previous work on intelligent storage and intelligent memory. The existing ecosystem and these new enabling technologies make this system more viable than earlier ones.
Non-conscious and automatic acquisition of body and excreta weight together with ballistocardiogram in a lavatory (2002)

For the purpose of health care monitoring during daily life, the authors attempted to devise a non-conscious monitoring system, set up in a lavatory, for the automatic acquisition of body weight, weight of urine and feces, together with ballistocardiogram as an index of cardiac function during relieving nature. The system consists of (i) a weight measuring platform (WMP) in which 4 load sensors were installed, and (ii) a data processing, displaying and storing (PDS) unit. The platform was placed on the float adjacent to a toilet bowl, and also supported the toilet seat so that the total body weight could be detected by the load sensors even in either case of standing or sitting on the seat. The prototype WMP had a weight resolution of about 5 gf, and thus those data could be accurately determined in an automatic manner with an appropriate processing. This paper describes an outline of the system, its performance and examples of measuring results, and a possible evaluation of cardiac function obtained from the ballistocardiogram is also discussed.
Notizen: Über die Hydrierung von Halogenverbindungen der 5. Hauptgruppe (1956)

Phenyl-arsen(V)-halogenide AsPh AsPh (n = 1, 2, 3) in Phenyl-arsen(III)-wasserstoffe (Phenylarsine) AsPhnH
Statistical analysis of protein kinase specificity determinants (1998)

The site and sequence specificity of protein kinases, as well as the role of the secondary structure and surface accessibility of the phosphorylation sites on substrate proteins, was statistically analyzed. The experimental data were collected from the literature and are available on the World Wide Web at http://www.cbs.dtu.dk/databases/PhosphoBase/. The set of data involved 1008 phosphorylatable sites in 406 proteins, which were phosphorylated by 58 protein kinases. It was found that there exists almost absolute Ser/Thr or Tyr specificity, with rare exceptions. The sequence specificity determinants were less strict and were located between positions -4 and +4 relative to the phosphorylation site. Secondary structure and surface accessibility predictions revealed that most of the phosphorylation sites were located on the surface of the target proteins.
Analysis of knee vibration signals using linear prediction (1992)

Clinical methods used at present for the diagnosis of cartilage pathology in the knee are invasive in nature, and carry some risks. There exists a need for the development of a safe, objective, noninvasive method for early detection, localization, and quantification of cartilage pathology in the knee. This paper investigates the possibility of developing such a method based on an analysis of vibrations produced by joint surfaces rubbing against one another during normal movement. In particular, the method of modeling by linear prediction is used for adaptive segmentation and parameterization of knee vibration signals. Dominant poles are extracted from the model system function for each segment based on their energy contributions and bandwidths. These dominant poles represent the dominant features of the signal segments in the spectral domain. Two-dimensional feature vectors are then constructed using the first dominant pole and the ratio of power in the 40-120 Hz band to the total power of the segment. The potential use of this method to distinguish between vibrations produced by normal volunteers and patients known to have cartilage pathology (chondromalacia) is discussed.
Low-dose inotropic therapy for ambulatory heart failure (1994)

Temple Hoyne Buell Heart Center Research Laborarories, Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado, USA.
On the Evolutionary Design of Quantum Circuits (2005)

The goal of this work is to understand the application of the evolutionary programming approach to the problem of quantum circuit design. This problem is motivated by the following observations: <ul> <li>In order to keep up with the seemingly insatiable demand for computing power our computing devices will continue to shrink, all the way down to the atomic scale, at which point they become quantum mechanical systems. In fact, this event, known as Moore?s Horizon, is likely to occur in less than 25 years. </li> <li> The recent discovery of several quantum algorithms which can solve some interesting problems more efficiently than any known classical algorithm. </li> <li> While we are not yet certain that quantum computers will ever be practical to build, there do now exist the first few astonishing experimental devices capable of briefly manipulating small quantities of quantum information. The programming of these devices is already a nontrivial problem, and as these devices and their algorithms become more complicated this problem will quickly become a significant challenge. </li> </ul> The Evolutionary Programming (EP) approach to problem solving seeks to mimic the processes of evolutionary biology which have resulted in the awesome complexity of living systems, almost all of which are well beyond our current analysis and engineering capabilities. This approach is motivated by the highly successful application of Koza?s Genetic Programming (GP) approach to a variety of circuit design problems, and specifically the preliminary reports byWilliams and Gray and also Rubinstein who applied GP to quantum circuit design. Accompanying this work is software for evolutionary quantum circuit design which incorporates several advances over previous approaches, including: <ul> <li>A formal language for describing parallel quantum circuits out of an arbitary elementary gate set, including gates with one or more parameters. </li> <li> A fitness assessment procedure that measures both average case fidelity with a respect for global phase equivalences, and implementation cost. </li> <li> A Memetic Programming (MP) based reproductive strategy that uses a combination of global genetic and local memetic searches to effectively search through diverse circuit topologies and optimize the parameterized gates they contain. </li> </ul> Several benchmark experiments are performed on small problems which support the conclusion that Evolutionary Programming is a viable approach to quantum circuit design and that further experiments utilizing more computational resources and more problem insight can be expected to yield many new and interesting quantum circuits.