gebhart/patrepeval huggingface dataset:
Effect of permeation enhancers on the iontophoretic transport of metoprolol tartrate and the drug retention in skin (2010)

Utilization of chemical penetration enhancers in conjunction with iontophoresis is regarded as the most effective method to enhance the passage of molecules across the skin barrier. A systematic approach to enhance the transdermal delivery of metoprolol tartrate and the subsequent release of the drug depot in the skin was investigated. Gel formulations with proximate viscosity were prepared and assessed for the effect of polymers (carbopol, hydroxypropyl methyl cellulose, and methyl cellulose), permeation enhancers (5% w/w, sodium lauryl sulfate (SLS), dimethyl formamide, n-methyl-2-pyrrolidone, and polyethylene glycol 400), and the combination approach (permeation enhancers with iontophoresis-0.5 mA/cm² on the drug delivery. The flux values observed in passive (4.59-5.89 µg/cm²/h) and iontophoresis (37.99-41.57 µg/cm²/h) processes revealed that the permeation of metoprolol was not influenced by the polymers studied, under similar conditions, and further studies were carried out using carbopol gel as a representative polymer. Appreciable enhancement (~5-fold) in drug delivery was observed with SLS in the passive process while the optimum iontophoretic delivery condition ensured better delivery (~7-fold). Combination of iontophoresis with SLS further enhanced the drug delivery (~9-fold) and leads to noticeable drug retention in the skin as well. Moreover, the drug retained in the cutaneous layer of the skin eventually released over a period of time (5 days) and followed a near first order profile. This study concludes that the combination of iontophoresis with SLS augmented the metoprolol delivery and rendered skin drug depot, which eventually released over a period of time.
Comparison of In-Line Connected Diode Array and Electrochemical Detectors in the High-Performance Liquid Chromatographic Analysis of Coenzymes Q<sub>9</sub> and Q<sub>10</sub> in Food Materials (2000)

In-line connected electrochemical (EC) and diode array (DAD) detectors were compared in the reversed-phase high-performance liquid chromatographic (RP-HPLC) analysis of coenzymes Q(9) and Q(10) in some food materials (beef steak, beef heart, Baltic herring fillet, and rye flour). Coenzymes Q(9) and Q(10) were extracted from the samples using a 5:1 n-hexane-ethanol mixture. Coefficient of variation (CV%) of quadruplicate or quintuplicate determined samples for coenzymes Q(9) and Q(10) was <10 by both EC detector and DAD. Responses of the detection systems were linear in the range evaluated, 10-200 ng/injection, and had correlation coefficients exceeding 0.999. Recoveries of added coenzymes Q(9) and Q(10) varied 73-105% for DAD and 74-103% for EC detector, respectively. Detection limits for coenzymes Q(9) and Q(10) using the DAD system were 4 and 6 ng/injection, respectively, and 0.2 and 0.3 ng/injection by EC detection. Results derived from the two detection systems were generally similar. However, although EC detector was 20-fold more sensitive, the selectivity was, in some cases, poorer than that of DAD.
A practical IDTV system improving picture quality for nonstandard TV signals (1988)

A practical improved-definition TV (IDTV) system is described that performs video component signal processing, automatic non-NTSC signal discrimination, and adaptively choosing between burst-locked and highly stable line-locked clocking. The system design is presented along with sample images highlighting its performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An Improved Empirical Model for Radar Sea Clutter Reflectivity (2012)

A fundamental characteristic of radar sea clutter, important for radar performance evaluations, is its apparent reflectivity defined a σ <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sup> (m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ). “Apparent” is used as a reminder that any measurement of sea clutter reflectivity includes the effects of propagation and shadowing close to the sea surface. Sea clutter reflectivity depends on many factors, including sea state, wind velocity, grazing angle, polarization, and radar frequency. An empirical sea clutter model proposed by Horst, et al. (1978), the so-called GIT model, has found widespread acceptance in the radar community. However, this model does not always agree with what is the most complete experimental database of sea clutter reflectivity available to the radar systems engineer. The 1991 edition of F. E. Nathanson's book provides seven tables of measured sea clutter reflectivity data summarized from approximately 60 sources. The large deviation between the GIT model and this database, in particular at lower sea states, has prompted NRL to develop an improved model for sea clutter reflectivity based on these tables. The model is a function of radar frequency, polarization, sea state, and grazing angle. The functional form of this empirical model was chosen such that the average absolute deviation (in dB) between the model and the experimental data was minimized.
Enzymatic and oxidative degradation of poly(polyol sebacate) (2013)

Poly(glycerol sebacate) (PGS) and poly(xylitol sebacate) (PXS) are biodegradable elastomers with tremendous potential in soft tissue engineering. This study was aimed at exploring the enzymatic degradation mechanisms of these polyesters, using biochemical conditions similar to those occurring in vivo. To this end, PGS and PXS (crosslinked at 130 for 2 or 7 (PGS)/12 days (PXS)) were incubated in vitro under physiological conditions in tissue culture media supplemented with either a biodegrading enzyme (esterase), an oxidant species (FeSO4/H2O2 with 0.11 molar ratio of Fe(2+/)H2O2), an oxidant generating enzyme (xanthine oxidase and xanthine) or combinations of these (FeSO4/H2O2 and esterase, or (v) xanthine oxidase/xanthine and esterase), based on their independent effects on polymer degradation. Testing was performed over 35 days of continuous incubation, during which mechanical properties, mass loss, biomaterial thickness and pH value of the culture medium were determined. Degradation kinetics of both PGS and PXS samples were primarily determined by the degree of crosslink density. Esterase and FeSO4/H2O2 accelerated the degradation of both polymers, by promoting hydrolysis and free-radical degradation, although this action was not affected by the presence of xanthine oxidase and xanthine. Degradation of PGS and PXS is primarily mediated by the action of esterase, with free-radical oxidation playing a secondary role, suggesting that both could synergistically affect the biodegradability of biomaterial implants, under more complex biological conditions.
Tracking Systems Evaluation for the “Hybrid Lighting System” (2003)

As part of the design and development effort for the “Hybrid Lighting System,” Oak Ridge National Laboratory (ORNL) scientists have evaluated two potential candidate-tracking systems for the solar collector. The first system, the WattSun Solar Tracker, built by Array Technologies, utilizes a patented, closed loop, optical sun sensor to sense the sun’s position and track it. The second tracking system, SolarTrak Controller, built by Enhancement Electronics, Inc., is a micro controller-based tracking system. The SolarTrak micro controller-based Tracker’s sun position is determined by computing the celestial bearing of the sun with respect to the earth using the local time, date, latitude, longitude and time zone rather than sensing the relative bearing of the sun with optical receptors. This system connects directly to the mechanical system hardware supplied by Array Technologies. Both the WattSun Solar Tracker and the SolarTrak Controller were mounted on the prototype “Hybrid Lighting” mechanical system (array) hardware. A simple switch allowed independent testing of each system. Upon completion of the evaluation of the two systems we found the WattSun Solar Tracker controller to be unacceptable for use with our prototype hybrid lighting system. The SolarTrak Controller has performed well to date and provides suitable tracking accuracy for use with our prototype “Hybrid Lighting System”. After a six-month evaluation period at ORNL, the first prototype “Hybrid Lighting System” was installed at Ohio University as part of an “Enhanced Practical Photosynthetic CO2 Mitigation.” This document will highlight the results of the tracker investigation and outline the remaining issues to be addressed, to provide a suitable tracking system for our “Hybrid Lighting” collector.
대학캠퍼스 공간사용 특성 및 방향에 관한 연구 (삼육대학교를 중심으로) (2012)

This study aims to make suggestions to improve practically the current space usage on the basis of the results of investigating the spatial size and intended use of each building in the campus premises of Sahmyook university to understand objectively the current status of space usage, Such the current status was investigated using the official schedule of each lecture room, and all buildings were directly visited to compare their actual spatial size and intended use to their drawings, Based upon the results of this investigation, the following conclusions were drawn: A, For some departments (e.g., Chemistry, Food & Nutrition, Business Administration Information, Art Content, Communication Design, etc.) whose primarily used buildings are divided into twos, it is considered necessary to arrange their separate buildings into a single one in future. B. Even if any spaces other than primarily used buildings are to be used, it is required to place them close to primarily used buildings as possible. C. It seems to be required to give careful consideration to the Department of Social Welfare occupying the oldest and smallest building as well as the Departments of Health Management and Animal Biotechnology which have been newly separated without primarily used buildings. D. As professors` laboratories generally tend to be not located mainly in the primarily used buildings, but scattered on campus, it is thought that it is pressing to improve that in the aspect of student management and educational efficiency. E. Finally, it is considered that further studies should address whether administrative spaces other than department offices are centralized, and thus require rearrangement.
A 1 GS/s 6-bit time-based analog-to-digital converter (T-ADC) for front-end receivers (2017)

Recently, researchers are targeting low-power consumption, and integrating more blocks on-chip. This paper proposes a 1GS/s 6-bit time-based analog-to-digital converter (T-ADC) for front-end receivers. This T-ADC eliminates the preprocessing analog blocks, and reduces power consumption by removing the power-hungry sample and hold circuit. A prototype of the proposed T-ADC is implemented in 65nm CMOS technology, where it consumes 1 mW and achieves a maximum SNDR of 35.5 dB with sampling rate 1 GHZ that corresponds to a Figure of Merit (FoM) of 20.62 fJ/step.
Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin (2013)

DNA topoisomerase II inhibitors are a major class of cancer chemotherapeutics, which are thought to eliminate cancer cells by inducing DNA double-strand breaks. Here we identify a novel activity for the anthracycline class of DNA topoisomerase II inhibitors: histone eviction from open chromosomal areas. We show that anthracyclines promote histone eviction irrespective of their ability to induce DNA double-strand breaks. The histone variant H2AX, which is a key component of the DNA damage response, is also evicted by anthracyclines, and H2AX eviction is associated with attenuated DNA repair. Histone eviction deregulates the transcriptome in cancer cells and organs such as the heart, and can drive apoptosis of topoisomerase-negative acute myeloid leukaemia blasts in patients. We define a novel mechanism of action of anthracycline anticancer drugs doxorubicin and daunorubicin on chromatin biology, with important consequences for DNA damage responses, epigenetics, transcription, side effects and cancer therapy.
Research on System Design and Control Technology of Vision-Based CyberCar (2006)

In this paper the vehicle structure, performance parameters and dynamic model of JLUIV5-CyberCar are discussed. An optimal controller is designed to achieve the line path tracking ability, while the curve path tracking ability is guaranteed by a fuzzy controller. To improve the tracking performance of the vehicle steering system in different conditions, controller output collections of JLUIV5-CyberCar are established combined with variable structure control theory. Design the state observer based on Kalman filter theory to estimate the lateral velocity and yaw rate. Simulations and experimental results have confirmed the effectiveness of the proposed method.
Inhibition of Injured <i>Escherichia coli</i> by Several Selective Agents (1971)

A population of Escherichia coli ML30 cells was exposed to a quaternary ammonium compound, and injury to the cells was measured by a comparison of counts on Trypticase Soy Agar and Violet Red Bile Agar. Substantial injury could not be detected with a minimal medium. The ingredients of Violet Red Bile Agar were tested against damaged cells. The bile salts mixture alone in the medium prevented as many injured cells from growing as did any combination of the selective agents and inhibited as many injured bacteria as were inhibited by Violet Red Bile Agar itself. These dyes and salts were similarly assayed in minimal agar, and comparable results were obtained. Individual bile salts and other potential selective agents were added to the minimal medium, and the media were tested for inhibition of injured E. coli. Sodium deoxycholate was the bile salt most inhibitory to damaged E. coli cells.
Inhibition of Stat3 expression induces apoptosis and suppresses proliferation in human leukemia HL-60 cells (2011)

Acute myeloid leukemia (AML) is the most common myeloid leukemia. It is highly malignant, thus, most patients with AML will relapse and die after traditional treatment. Stat3, a member of the signal transducer and activator of transcription (Stat) family, is involved in the development and progression of many tumors. The purpose of the study was to investigate whether the down-regulation of Stat3 expression by RNA interference is effective against human leukemia HL-60 cells. The results indicated that constitutively expressed Stat3 is present in human leukemia HL-60 cells, and the down-regulation of Stat3 expression caused significant induction of apoptosis as well as inhibition of proliferation in HL-60 cells. These data further demonstrated that Stat3 plays a critical role in human leukemia HL-60 cell apoptosis and proliferation. Thus, targeting Stat3 may be a useful adjunctive treatment strategy in AML.
PCR-DNA probe assays for identification and detection of Prevotella intermedia sensu stricto and Prevotella nigrescens (1997)

The purpose of this study was to construct PCR-DNA probe assays specific for Prevotella intermedia sensu stricto and Prevotella nigrescens based on the ability of randomly amplified polymorphic DNA (RAPD) fingerprinting to generate species-specific markers. The strategy included four steps: (i) construction of first-generation DNA probes from a 850-bp RAPD marker for P. intermedia sensu stricto and a 1,300-bp RAPD marker for P. nigrescens, (ii) cloning and sequencing of each RAPD marker, (iii) designing of primer pairs flanking specific internal sequences of 754 bp for P. intermedia sensu stricto and of ca. 1,100 bp for P. nigrescens, and (iv) synthesis (by PCR amplification) and digoxigenin labeling of quantities of DNA probes 754 and ca. 1,100 bp in size. The PCR-DNA probe assays combine either PCR amplification of a 754-bp specific sequence in the genomic DNA of strains of P. intermedia sensu stricto and hybridization with the 754-bp digoxigenin-labeled probe or amplification of a ca. 1,100-bp sequence of P. nigrescens and hybridization with the ca. 1,100-bp probe. Specific hybridization was observed with the amplified DNAs from 25 strains of P. intermedia and 24 strains of P. nigrescens, and no reaction was observed with the PCR products from 20 foreign species. The PCR-DNA probe assays described here should allow a highly specific and sensitive detection of P. intermedia sensu stricto and P. nigrescens in mixed infections.
[Aromatase inhibitors]. (1999)

Aromatase inhibitors used in breast cancer, are drugs that inhibit the transformation of androstenedione and testosterone, respectively in estradiol and estrone. Two classes have been described: steroidal inhibitors which act competitively and irreversibly and non steroidal inhibitors which block the P 450 cytochrome. The first one is aminoglutethimide which has an adrenal effect on 11, 18 and 21 hydroxylase. Rogletimide, less powerful and less specific is a aminoglutethimide analogue. The response rates obtained with formestane is not different. The clinical development has been stopped due to a lack of specificity. Letrozole, vorozole, exemestane and anastrozole are more powerful and more specific. Letrozole and vorozole are at least as efficient and better tolerated than aminoglutéthimide. Anastrozole, letrozole and vorozole are at least as efficient as megestrol acetate and better tolerated in advanced breast cancer patients receiving a second line hormone therapy.
Two novel mutations, Q1053H and C1060R, located in the D3 domain of von Willebrand factor, are responsible for decreased FVIII‐binding capacity (2003)

In type 2N von Willebrand disease (VWD), von Willebrand factor (VWF) is characterized by a markedly decreased affinity for Factor VIII (FVIII), and the mutations responsible are essentially located in the D' domain of VWF. We report the identification, in seven unrelated French families, of two novel type 2N VWD mutations, Q1053H and C1060R (Gln290His and Cys297Arg in mature VWF sequence), in exon 24 of the VWF gene. These missense mutations have been identified in the heterozygous, homozygous or hemizygous states. Using site-directed mutagenesis and transient expression in COS-7 cells, we showed that both mutations, although located in the D3 domain of VWF, outside the tryptic fragment containing the FVIII domain, dramatically decrease the binding of VWF to FVIII. In contrast, the R924Q substitution, which was identified in a patient who was heterozygous for C1060R, was shown to be a polymorphism.
A self-organizing knowledge representation scheme for extensible heterogeneous information environment (1992)

The self-organizing knowledge representation aspects in heterogeneous information environments involving object-oriented databases, relational databases, and rulebases are investigated. The authors consider a facet of self-organizability which sustains the structural semantic integrity of an integrated schemea regardless of the dynamic nature of local schemata. To achieve this objective, they propose an overall scheme for schema translation and schema integration with an object-oriented data model as common data model, and it is shown that integrated schemata can be maintained effortlessly by propagating updates in local schemata to integrated schemata unambiguously.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Stability of free and immobilized Lactobacillus acidophilus and Bifidobacterium lactis in acidified milk and of immobilized B. lactis in yoghurt (2004)

This study evaluated the stability of Bifidobacterium lactis (Bb-12) and of Lactobacillus acidophilus (La-05) both free and immobilized in calcium alginate, in milk and in acidified milk (pH 5.0, 4.4 and 3.8). The stability of immobilized B. lactis in yoghurt (fermented to pH 4.2), during 28 days of refrigerated storage was also evaluated. The efficiency of two culture media (modified MRS agar and Reinforced Clostridial Agar plus Prussian Blue) for counting of B. lactis in yoghurt was determined. Lee's agar was used to count Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus when B. lactis were counted in the MRS medium. B. lactis and L. acidophilus in both free and immobilized forms presented satisfactory rates of survival in milk and acidified milk because the average reduction of the population was only one log cycle after 21 days of storage. The number of viable cells of immobilized B. lactis in yoghurt presented a gradual decline throughout the storage period, passing from 10(8) cfu/ml to no count after 28 days of storage. When the cultures were not in equilibrium just the selective medium was efficient in counting B. lactis in yoghurt. The results showed that both microorganisms can be added to milk and acidified milk, because their population was only slightly affected during storage. The presence of traditional culture of yoghurt seems to be harmful for survival of immobilized B. lactis and the immobilization in calcium alginate failed as an effective barrier to protect the cells in all analysed treatments.
Sports injuries of the knee ligaments: their diagnosis, treatment, rehabilitation, and prevention (1976)

This paper was presented as the fourth J. B, Wolffe Lecture at the Twenty-Third Annual Meeting of the American College of Sports Medicine in Anaheim, California, May 5-8, 1976.
Perineal Puborectalis Sling Operation for Fecal Incontinence: Preliminary Report (2004)

We believe that the perineal puborectalis sling operation is technically feasible, with low morbidity, and can be an effective procedure for idiopathic fecal incontinence.
Online algorithms in high-frequency trading (2013)

The challenges faced by competing HFT algorithms.
Wide-band pulse-echo imaging with distributed apertures in multi-path environments (2008)

We derive a new image reconstruction method for distributed apertures operating in complex environments. The aperture elements can be distributed spatially in an arbitrary fashion, can be several hundred wavelengths apart, and can involve transmission from multiple elements simultaneously. Moreover, the object to be imaged can be either in the near-field or far-field of the array. Our method is capable of exploiting information about multi-path scattering in the environment, statistics of the objects to be imaged and statistics of the additive (possibly non-stationary) noise. We formulate the image reconstruction problem as an inversion of a bilinear mapping that maps object reflectivity to an operator which in turn acts on the transmitted waveforms. We use transmitted waveforms to reveal the action of this bilinear mapping. We develop a minimum-norm inversion which takes the form of a family of linear operators applied to the pulse-echo measurements. This processing is implemented by means of inner products between the measurements and pre-computed quantities, separately for each receiving element. Our approach is therefore well suited for parallel implementation, and can be performed in a distributed manner.
Contributors, Oct. 1973 (1973)

Presents a biographical entry for each author and co-author included in this issue of the publication.