gebhart/patrepeval huggingface dataset:
Hybrid Fluorocarbon−Hydrocarbon CO<sub>2</sub>-philic Surfactants. 2. Formation and Properties of Water-in-CO<sub>2</sub> Microemulsions (2004)

Hybrid fluorocarbon-hydrocarbon (F-H) sulfate surfactants are shown to be efficient stabilizers in water-in-CO2 (w/c) microemulsions. The chain structure and F-H ratio affect the regions of P-T phase stability and aggregation structure in these w/c phases. High-pressure near-infrared spectroscopy and small-angle neutron scattering measurements of microemulsified water provide evidence for the stabilization of w/c microemulsion droplets. The relative lengths of the two chains were found to influence the favored aggregation structure: for symmetric chain surfactants (F8H8, F7H7) spherical reverse micelles are present, but for asymmetric chain surfactants (F7H4, F8H4) extended cylinder aggregates form. These changes in aggregation are consistent with different surfactant packing parameters owing to the controlled variations in molecular structure. Furthermore, the general order of w/c phase transition pressures (F8H8 < F7H7 and F8H4 < F7H4) is in line with estimations of surfactant fractional free volume, as proposed by Johnston et al. (J. Phys. Chem. B 2004, 108, 1962-1966). Studies of adsorption at the poly(dimethylsiloxane)-water interface are shown to be valuable for assessing the CO2-philicity of new surfactants. All in all, the symmetric F8H8 and F7H7 analogues are seen to be the most efficient compounds from this class for applications in CO2.
Isolation and characterization of osmosensitive vacuolar mutants of <i>Saccharomyces cerevisiae</i> (1991)

The yeast vacuole plays an important role in nitrogen metabolism, storage and intracellular macromolecular degradation. Evidence suggests that it is also involved in osmohomeostasis of the cell. We have taken a mutational approach for the analysis of vacuolar function and biogenesis by the isolation of 97 mutants unable to grow if high concentrations of salt are present in the medium. Phenotypic analysis was able to demonstrate that apart from osmosensitivity the mutations also conferred other properties such as altered vacuolar morphology and secretion of the vacuolar enzymes carboxypeptidase Y, proteinase A, proteinase B and alpha-mannosidase. The mutants fall into at least 17 complementation groups, termed ssv for salt-sensitive vacuolar mutants, of which two are identical to complementation groups isolated by others. We conclude that in Saccharomyces cerevisiae correct vacuolar biogenesis and protein targeting is required for osmotolerance as well as other important cellular processes.
IgE levels in faecal extracts of patients with food allergy (1992)

IgE levels in faecal extracts (Copro-IgE levels) were investigated in food allergy (FA) patients before and after the challenge test administration of food allergens. IgE levels were measured by time-resolved fluoroimmunometric assay. In addition, the effects of administration of oral sodium cromoglycate (SCG) on the Copro-IgE levels were studied. Copro-IgE levels in patients with FA, who were placed on an elimination diet, did not differ from those of healthy children. After a challenge test immediate symptoms of urticaria and wheezing were observed in all FA patients. Copro-IgE levels in each patient increased markedly within 24 h of the challenge test. Moreover, FA patients treated orally with SCG showed neither the increase in Copro-IgE levels nor any remarkable symptoms after the challenge. Our results suggest that the increased Copro-IgE levels may be a specific consequence of the local immune response to food allergen stimulation in the gut mucosa.
A Content-adaptive Fast Multiple Reference Frames Motion Estimation in H.264 (2007)

The H.264/AVC video coding standard adopts various advanced coding techniques such as variable block sizes and multiple reference frames motion compensation (MRF-MC). The computational burden of motion estimation increases as the number of reference frames searched. In this paper, we present a content-adaptive fast motion estimation algorithm. This algorithm fully uses the temporal and spatial content information at frame, MB and block levels to speed up the search process for multiple reference frames. Simulation results show that the proposed algorithm can be 3.6 times faster than the multiple reference frames UMHexagonS scheme, with negligible degradation of video quality.
Fever After Zoledronic Acid Administration Is Due to Increase in TNF- <i>α</i> and IL-6 (2003)

The most common adverse event typically associated with bisphosphonate therapy is transient fever. The aim of this study was to define the role of the main cytokines of the acute-phase reaction interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) involved in the pathogenesis of zoledronic acid-induced fever. Eighteen consecutive cancer patients with bone metastases were treated, for the first time, with a single dose of 4 mg zoledronic acid infusion. They were prospectively evaluated for circulating TNF-alpha, interferon-gamma (IFN-gamma), and IL-6 levels at different times, just before and 1, 2, 7, and 21 days after diphosphonate infusion. Clinical and standard laboratory parameters were recorded at the same time points. TNF-alpha circulating levels increased significantly 1 and 2 days after zoledronic acid infusion (respectively, p = 0.002 and p < 0.001) and then decreased to levels similar to the basal levels. IL-6 levels increased significantly 1 day after the infusion (p = 0.007), returning to values similar to the median basal values 2 days after zoledronic acid administration. Moreover, in patients who experienced fever, the TNF-alpha and IL-6 increases were higher than in patients without fever. No statistically significant differences in IFN-gamma were identified at different time points in patients with and without fever. Our results show that zoledronic acid induces transient TNF-alpha and IL-6 increases and that these increases are higher in patients who have developed fever, suggesting that these cytokines could be responsible for fever pathogenesis. The sharp reduction in serum calcium levels observed in patients with fever may be related to zoledronic acid pharmacokinetic modifications.
Hierarchical federations: an architecture for information hiding (2001)

In a distributed simulation, simulation components of various types are executed at geographically different locations, forming a simulation federation to create a common virtual environment. Under the High Level Architecture (HLA), information that will be produced and consumed by a simulation component is defined in its object model, and how that information is produced and consumed is well encapsulated inside the simulation component's implementation. However, in the current implementation of the HLA's Runtime Infrastructure (RTI), information hiding between groups of simulation components in a simulation federation is not addressed. In this paper, we discuss how hierarchical federations architectures can be used to tackle this problem. The hierarchical federations architecture adopted in this paper differs from the existing architectures in that it is based on a hybrid approach for inter-operability between simulation federations. To demonstrate the information hiding using the architecture, a distributed semiconductor supply-chain simulation is also described in the paper.
A Decision Support System for the Economic Evaluation of Building Regulations (1994)

This paper describes the Economic Evaluation System which has been designed to assist those drafting and using building regulations. The introduction provides a brief background and identifies some of the advantages of the system. The system's three main components, the data management, analysis model and the communication component are explained. The evaluation methodology suggested is described with particular attention to the identification and quantification of costs, risks and benefits. Excerpts of a recently completed evaluation which examined the proposal to require smoke detectors to be installed in all new houses is reproduced to verify the methodology. While this study was performed on a deterministic basis a stochastic model has been employed to check subjective estimates.
Safety of Tumescent Liposuction in 15,336 Patients (1995)

Tumescent liposuction is an exceptionally safe method of liposuction under local anesthesia that eliminates the necessity of general anesthesia and blood transfusions. Tumescent liposuction is safer than liposuction under general anesthesia and results in fewer complications.
From a Parkinson's disease expert: Rasagiline and the Future of Therapy (2007)

John Finberg is a professor of pharmacology at the Faculty of Medicine, Technion - Israel Institute of Technology, home of Israel's two Nobel laureates. He and his colleague Prof. Moussa Youdim were instrumental in the early clinical development of the anti-Parkinson drug rasagiline, which gained UK- and EU-marketing authorization in 2005 and US FDA approval in 2006. In our interview, Finberg reflects on his clinical research to develop rasagiline as a commercial drug and its proposed pharmacological mechanisms of action. Moreover, he elucidates the current state of anti-Parkinson drug discovery and offers direction for future research.
Isolation of rat chromosome-specific paint probes by bivariate flow sorting followed by degenerate oligonucleotide primed-PCR (1994)

The flow karyotype of rat chromosomes was determined by dual beam flow cytometry. Eighteen fractions were sorted and subsequently amplified by degenerate oligonucleotide primed-PCR as described by Telenius et al. (1992a, 1992b). The PCR products were labeled and used as probes for fluorescence in situ hybridization on rat fibroblast metaphases. The amplified chromosomes were detectable as bright chromosome paints and in most cases the signal was evenly distributed along the whole chromosome except for the centromeric region in half of the chromosomes. The results show that chromosomes 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 19, 20, X and Y can be sorted as individual fractions, whereas chromosomes 11, 13, 14, 15 and chromosomes 16, 17 and 18 are clustered together in the flow karyotype.
Diversification of Pyrazoles by Microwave-assisted Ligand Free Copper Catalyzed N-Arylation (2012)

Bio-Organic Science Division, KRICT, Yuseong, Daejeon 305-600, KoreaReceived March 2, Accepted March 14, 2012Key Words : Pyrazole, Microwave, Ligand free, Copper, N-ArylationPyrazole and its derivatives exhibit interesting chemicaland biological properties, so the derivatives are widely usedin pharmaceuticals, agrochemicals, food additives, dyes,materials, and cosmetic coloring agents.
Configuration of the optical transmission line using stimulated Raman scattering for signal light amplification (1986)

Expansion of a repeater spacing of optical transmission line is investigated using forward stimulated Raman scattering generated by a 1.34-μm Nd:YAG laser to amplify the signal light. Achievable repeater spacing at the 1.42-μm wavelength transmission is numerically estimated on the basis of coupled power equations and experimentally obtained Raman gain for various core-cladding index difference. A transmission distance of more than 200 km is predicted for an input signal light power of 100 μw and a pump power of 200 mW using a fiber with a relative index difference of 1 percent.
MicroRNA Polymorphisms and Risk of Colorectal Cancer (2014)

This study demonstrates the potential for an miRNA-targeted genome-wide association study to identify candidate susceptibility loci and prioritize them for functional characterization.
Epithelial contact guidance on well-defined micro- and nanostructured substrates (2003)

The human corneal basement membrane has a rich felt-like surface topography with feature dimensions between 20 nm and 200 nm. On the basis of these findings, we designed lithographically defined substrates to investigate whether nanotopography is a relevant stimulus for human corneal epithelial cells. We found that cells elongated and aligned along patterns of grooves and ridges with feature dimensions as small as 70 nm, whereas on smooth substrates, cells were mostly round. The percentage of aligned cells was constant on substrate tomographies with lateral dimensions ranging from the nano- to the micronscale, and increased with groove depth. The presence of serum in the culture medium resulted in a larger percentage of cells aligning along the topographic patterns than when no serum was added to the basal medium. When present, actin microfilaments and focal adhesions were aligned along the substrate topographies. The width of the focal adhesions was determined by the width of the ridges in the underlying substrate. This work documents that biologic length-scale topographic features that model features encountered in the native basement membrane can profoundly affect epithelial cell behavior.
Silicided shallow junction formation by ion implantation of impurity ions into silicide layers and subsequent drive-in (1987)

We have developed a technique for the fabrication of shallow, silicided n+−p and p+−n junctions with good electrical characteristics. The technique utilizes the ion implantation of dopants into silicide layers previously formed by ion-beam mixing with Si ions and low-temperature annealing, and the subsequent drive-in of implanted dopants into the Si substrate to form shallow junctions. This technique can be applied to the fabrication of metal-oxide-semiconductor field-effect transistor in a self-aligned fashion and can have a significant impact on complementary metal-oxide-semiconductor devices.
Plasma Nutrients in Joint and Muscle Pain Patients Before and After Nutritional Therapy (1997)

A total of 27 patients (females n= 19 and males n= 8) with musculoskeletal symptoms had their plasma antioxidant ubiquinone plus vitamin E (a-tocopherol) and their essential fatty acids (EFAs) analyzed. They were antioxidant depleted but had normal w-6 and w-3 EFA levels as compared to healthy individuals. Nutritional therapy with either ubiquinone and vitamin E (study A, n= 16) alone or in combination with w-3 EFAs as a fish oil concentrate (study B, n= 11) increased plasma antioxidants after 3 months of nutritional therapy. Only the inclusion of w-3 EFAs (study B) had an effect on the plasma EFA and increased the w-3 series in absolute and relative terms. No gender differences were present either before or after the nutritional therapy. When antioxidant therapy was evaluated with respect to the patients' smoking habits, only the non-smokers appeared to gain w-3 EFA protection. The effect of antioxidants alone in the non-smokers and in combination with w-3 EFAs in all the patients seemed to depress the presence of one w-6 fatty acid in particular: arachidonic acid (AA). It seems reasonable to suggest that this could result in a reduced AA cascade
Incorporating 4D Seismic Data in Reservoir Simulation Models Using Ensemble Kalman Filter (2005)

Summary A method based on the ensemble Kalman filter (EnKF) for continuous model updating with respect to the combination of production data and 4D seismic data is presented. When the seismic data are given as a difference between two surveys, a combination of the ensemble Kalman filter and the ensemble Kalman smoother has to be applied. Also, special care has to be taken because of the large amount of data assimilated. Still, the method is completely recursive, with little additional cost compared to the traditional EnKF. The model system consists of a commercial reservoir simulator coupled to a rock physics and seismic modelling software. Both static variables (porosity, permeability, rock physic parameters, etc.) and dynamic variables (saturations and pressures) may be updated continuously with time based on the information contained in the assimilated measurements. The method is applied to a synthetic model and a real field case from the North Sea. In both cases, the 4D seismic data are different variations of inverted seismic. For the synthetic case, it is shown that the introduction of seismic data gives a much better estimate of reservoir permeability. For the field case, the introduction of seismic data gives a very different permeability field than using only production data, while retaining the production match.
Understanding respiratory syncytial virus (RSV) vaccine development and aspects of disease pathogenesis (2015)

Respiratory syncytial virus (RSV) is the most important cause of lower respiratory tract infections causing bronchiolitis and some mortality in young children and the elderly. Despite decades of research there is no licensed RSV vaccine. Although significant advances have been made in understanding the immune factors responsible for inducing vaccine-enhanced disease in animal models, less information is available for humans. In this review, we discuss the different types of RSV vaccines and their target population, the need for establishing immune correlates for vaccine efficacy, and how the use of different animal models can help predict vaccine efficacy and clinical outcomes in humans.
Progression types after antiangiogenic therapy are related to outcome in recurrent glioblastoma (2014)

Radiologic PTs following bevacizumab treatment failure show differences in time to development and are related to outcome. We therefore hypothesize that these PTs reflect a different glioma biology, including differential resistance mechanisms to bevacizumab, and may be associated with different responses to postprogression therapy.
DCS-ctrl: A Fast and Flexible Device-Control Mechanism for Device-Centric Server Architecture (2018)

Modern high-performance servers leverage a large number of emerging peripheral devices (e.g., data processing accelerators, non-volatile memory storage, high-bandwidth network cards) to meet ever-increasing performance demands of server applications. However, as such servers experience severe kernel overhead due to frequently invoked device operations (e.g., buffer management and data copy), server architects have proposed various hardware and software approaches to enable direct communications among the devices. Unfortunately, existing direct device-to-device (D2D) communication schemes still suffer from low performance and the lack of flexibility. First, software-based schemes depend on complicated kernel routines and necessitate multiple hardware-software and user-kernel boundary crossings, which significantly limit the performance improvement opportunities from direct D2D communications. On the other hand, hardware-based schemes require tight integration and custom-built devices, preventing architects from flexibly adding off-the-shelf devices. In this paper, we propose DCS-ctrl, a novel Hardware-based Device-Control (HDC) mechanism for Device-Centric Server (DCS) architecture to provide fast and CPU-efficient direct D2D communications among a large number of off-the-shelf peripheral devices. The key idea of DCS-ctrl is to implement a low-cost and flexible device-control mechanism on an independent FPGA device called HDC Engine. As HDC Engine manages all data and control transfers among devices at the hardware level, the server achieves high performance, scalability, and flexibility. First, optimizing both data and control paths at the hardware level minimizes the latency of inter-device communications. Second, implementing FPGA-based reconfigurable device controllers enables direct D2D communications among commodity devices and thus improves per-device flexibility. Third, merging heterogeneous device operations with intermediate data processing supports creates more opportunities for direct inter-device communications in server applications. Our DCS-ctrl prototype reduces the latency of software-based direct D2D communications by 42% and the CPU utilization by 52%.
Analysis of mutations in the thymidine kinase genes of drug-resistant varicella-zoster virus populations using the polymerase chain reaction (1991)

We have applied the polymerase chain reaction (PCR) technique to analyse mutations in the thymidine kinase (TK) gene of varicella-zoster virus (VZV) associated with resistance to the 5-bromovinyl (BVaraU) and 5-propynyl (PYaraU) analogues of arabinofuranosyl deoxyuridine. The results from this study allow three clear conclusions to be drawn. Firstly, the technique clearly shows that populations of VZV derived from plaque purification were truly clonal only when the plaques were initiated from cell-free virus (representing a tiny fraction of infectious virus) and plaques initiated by infected cells contained a mixture of variants. Secondly, despite the background mutations caused by errors of the Taq DNA polymerase, mutations relevant to drug resistance can easily be distinguished. The BVaraU-resistant mutant, 7-1, contained an aspartic acid to asparagine mutation at residue 18 and a single base deletion (position 65298 of the VZV DNA sequence), resulting in a frameshift and premature termination of the polypeptide chain, was found in the BVaraU-resistant mutant YSR. PYaraU-resistant virus populations contained viruses with one or more of three independent mutations, i.e. single base substitutions resulting in mutations from leucine to proline at residue 92, histidine to arginine at residue 97 and a deletion of 20bp (residues 65,135 to 65,154). Finally, the technique has uncovered novel sites in the virus TK associated with drug resistance. We conclude that in vitro amplification using the PCR combined with cloning and sequencing is a relatively rapid method for identifying mutations in small virus populations even when they are not homogeneous.
HLA-B27 in inbred and non-inbred transgenic mice. Cell surface expression and recognition as an alloantigen in the absence of human <i>beta</i>  2-microglobulin. (1988)

A gene encoding the H chain of the human class I MHC Ag HLA-B27 was introduced into the germ lines of inbred C57BL/6 (B6) and non-inbred (B6 X SJL/J) F2 mice. By immunofluorescence and flow cytometry, the HLA-B27 gene product was expressed on lymphoid cells at levels comparable to the endogenous H-2b and H-2s class I MHC molecules. In both primary and secondary MLC between responder spleen cells from non-transgenic (B6 X SJL/J) F1 mice and transgenic stimulator cells, CTL were generated that specifically lysed mouse L cell (H-2k) or human B cell targets expressing HLA-B27, and this lysis thus appeared largely unrestricted by H-2. These results indicate that transgenic mice express a functional HLA-B27 gene product on cell surfaces in the absence of the human beta 2-microglobulin gene. These transgenic mice promise to be a valuable resource in the investigation of the unique role of HLA-B27 in inflammatory human disease.
Artificial Neural Network Based Optical Character Recognition (2012)

Optical Character Recognition deals in recognition and classification of characters from an image. For the recognition to be accurate, certain topological and geometrical properties are calculated, based on which a character is classified and recognized. Also, the Human psychology perceives characters by its overall shape and features such as strokes, curves, protrusions, enclosures etc. These properties, also called Features are extracted from the image by means of spatial pixel-based calculation. A collection of such features, called Vectors, help in defining a character uniquely, by means of an Artificial Neural Network that uses these Feature Vectors.