gebhart/patrepeval huggingface dataset:
Intake ground vortex aerodynamics (2008)

When an aircraft is operating in static or near static conditions during taxiing or take-o \na vortex can form between the ground and the intake. With engine diameters increasing,\nintakes are moving non-dimensionally closer to the ground and as a consequence\nthe likelihood of vortex formation during the aircraft operating envelope is set to increase.\nTo date there is little quantitative knowledge therefore a greater understanding\nis required. This research is aimed at providing an extensive quantitative parametric\nstudy of vortex formation leading to advanced design rules for future engines.\nA 1/30\nth\nscale generic model intake was operated in the Cranfield University 8 ′\n×\n6 ′\nwind tunnel to examine ground vortex formation under quiescent, headwind and crosswind\nconditions. Stereoscopic Particle Image Velocimetry and total pressure measurements\nhave been extensively taken to assess the external and internal flowfields. For\nthe first time experiments with a rolling ground plane have been performed to provide\ninsight into the formation and characteristics of ground vortices during take-o .\nAs the velocity ratio reduces a characteristic trend is established whereby the vortex is\ninitially weak, increases in strength to a local maximum and reduces to zero thereafter.\nThe operating points that generate the strongest vortex for a given configuration have\nbeen determined and an empirical model has been developed which can predict the vortex\nstrength and fan face distortion for any configuration. Under headwind conditions\na new vortex formation criterion has been established which also includes contours of\nvortex circulation. An a priori prediction of the vortex strength under headwind conditions\nhas also been developed which considers the approaching and intake induced\nvorticity sources, the latter of which is determined empirically. Good agreement is\nfound between the model and the experimental dataset. The rolling ground plane experiments\ndemonstrate significant sensitivities illustrating that the correct conditions\nmust be simulated properly.
Characterization of poultry egg-white avidins and their potential as a tool in pretargeting cancer treatment (2003)

Chicken avidin and bacterial streptavidin are proteins used in a wide variety of applications in the life sciences due to their strong affinity for biotin. A new and promising use for them is in medical pretargeting cancer treatments. However, their pharmacokinetics and immunological properties are not always optimal, thereby limiting their use in these applications. To search for potentially beneficial new candidates, we screened egg white from four different poultry species for avidin. Avidin proteins, isolated from the duck, goose, ostrich and turkey, showed a similar tetrameric structure, similar glycosylation and stability against both temperature and proteolytic activity of proteinase K as chicken avidin. Biotin-binding properties of these avidins, measured using IAsys optical biosensor, were similar to those found in avidin from the chicken. Three of these novel avidins, however, showed different immunological cross-reactivities when compared with chicken avidin. The patient sera responses to duck, goose and ostrich avidins were also lower than those observed for chicken and turkey avidins. Our findings suggest that the use of these proteins offers advantages over chicken avidin and bacterial streptavidin in pretargeting applications.
Synthesis ofStreptococcus pneumoniae Type 3 Neoglycoproteins Varying in Oligosaccharide Chain Length, Loading and Carrier Protein (2001)

The preparation is described of a range of neoglycoproteins containing synthesised fragments of the capsular polysaccharide of Streptococcus pneumoniae type 3, that is beta-D-GlcpA-(1-->4)-beta-D-Glcp-(1-->O)-(CH2)3NH2 (1), beta-D-Glcp-(1-->3)-beta-D-GlcpA-(1-->4)-beta-D-Glcp-(1-->O)-(CH2)3NH2 (2), and beta-D-GlcpA-(1-->4)-beta-D-Glcp-(1-->3)-beta-D-GlcpA-(1-->4)-beta-D-Glcp-(1-->O)-(CH4)NH2 (3). A blockwise approach was developed for the synthesis of the protected carbohydrate chains, in which the carboxylic groups were introduced prior to deprotection by selective oxidation of HO-6 in the presence of HO-4 by using TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy radical). After deprotection, the 3-aminopropyl spacer of the fragments was elongated with diethyl squarate (3,4-diethoxy-3-cyclobutene-1,2-dione) and the elongated oligosaccharides were conjugated to CRM197 (cross-reacting material of diphtheria toxin), KLH (keyhole limpet hemocyanin) or TT (tetanus toxoid). The resulting neoglycoconjugates varied in oligosaccharide chain length, oligosaccharide loading and protein carrier. These well-defined conjugates are ideal probes for evaluating the influence of the different structural parameters in immunological tests.
Amidines. 3. Thioureas possessing antihypertensive activity (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmidines. 3. Thioureas possessing antihypertensive activityBernard Loev, Paul E. Bender, Helene Bowman, Anna Helt, Richard McLean, and Timothy JenCite this: J. Med. Chem. 1972, 15, 10, 1024–1027Publication Date (Print):October 1, 1972Publication History Published online1 May 2002Published inissue 1 October 1972https://pubs.acs.org/doi/10.1021/jm00280a007https://doi.org/10.1021/jm00280a007research-articleACS PublicationsRequest reuse permissionsArticle Views349Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chitosan Rate of Uptake in HEK293 Cells is Influenced by Soluble versus Microparticle State and Enhanced by Serum-Induced Cell Metabolism and Lactate-Based Media Acidification (2013)

Media acidification mediates minor in vitro uptake of non-biofouled soluble chitosan chains, while serum-biofouled insoluble chitosan microparticles require sustained serum exposure to generate energy required for macropinocytosis.
Metabolic labeling to characterize the overall composition of <i>Francisella</i> lipid A and LPS grown in broth and in human phagocytes (2013)

A hallmark of Francisella tularensis, a highly virulent Gram-negative bacterium, is an unusual LPS that possesses both structural heterogeneity and characteristics that may contribute to innate immune evasion. However, none of the methods yet employed has been sufficient to determine the overall LPS composition of Francisella. We now demonstrate that metabolic labeling of francisellae with [(14)C]acetate, combined with fractionation of [(14)C]acetate-labeled lipids by ethanol precipitation rather than hot phenol-water extraction, permits a more sensitive and quantitative appraisal of overall compositional heterogeneity in lipid A and LPS. The majority of lipid A of different francisellae strains grown in diverse bacteriologic media and within human phagocytes accumulated as very hydrophobic species, including free lipid A, with <10% of the lipid A molecules substituted with O-Ag polysaccharides. The spectrum of lipid A and LPS species varied in a medium- and strain-dependent fashion, and growth in THP-1 cells yielded lipid A species that were not present in the same bacteria grown in brain heart infusion broth. In summary, metabolic labeling with [(14)C]acetate greatly facilitates assessment of the effect of genotypic and/or environmental variables on the synthesis and accumulation of lipid A and LPS by Francisella, including during growth within the cytosol of infected host cells.
Preface: Trends in Natural and Machine Intelligence (2012)

Trends in natural and machine intelligence are increasingly reflecting a convergence in these two well-established fields of study. The Third International Neural Network Society Winter Conference (INNS-WC 2012) was held in Bangkok, Thailand, on October 3-5, 2012. INNS-WC2012, with an aim to bring together scientists, practitioners, and students worldwide, to discuss the past, present, and future challenges and trends in the area of natural and machine intelligence. This event has been a bi-annual conference of the International Neural Network Society (INNS) to provide a forum for international researchers to exchange latest ideas and advances on neural networks and related discipline.
Speech synthesis from short-time Fourier transform magnitude and its application to speech processing (2005)

In this paper, speech synthesis directly from the processed Short-Time Fourier Transform Magnitude (STFTM) using the LSEE-MSTFTM algorithm [6,7] is compared to more conventional algorithms for several speech processing applications. For the applications considered, the most improvement occurs for time-scale modification of multiple speaker speech and noisy speech since these input signals are not well modeled by the analysis/synthesis system used for comparison. However, for the applications of speech synthesis from speech model parameters, time-scale modification of clean speech, speech enhancement by spectral subtraction, and helium speech enhancement, significant improvement is not gained by using the LSEE-MSTFTM algorithm. Significantly better results are not obtained since a good STFT phase estimate is available and employed in the conventional approaches to these applications.
Neurodegeneration with Brain Iron Accumulation: Genetic Diversity and Pathophysiological Mechanisms (2015)

Neurodegeneration with brain iron accumulation (NBIA) comprises a heterogeneous group of progressive disorders with the common feature of excessive iron deposition in the brain. Over the last decade, advances in sequencing technologies have greatly facilitated rapid gene discovery, and several single-gene disorders are now included in this group. Identification of the genetic bases of the NBIA disorders has advanced our understanding of the disease processes caused by reduced coenzyme A synthesis, impaired lipid metabolism, mitochondrial dysfunction, and defective autophagy. The contribution of iron to disease pathophysiology remains uncertain, as does the identity of a putative final common pathway by which the iron accumulates. Ongoing elucidation of the pathogenesis of each NBIA disorder will have significant implications for the identification and design of novel therapies to treat patients with these disorders.
Poly(3,4-ethylenedithiathiophene). A New Soluble Conductive Polythiophene Derivative (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPoly(3,4-ethylenedithiathiophene). A New Soluble Conductive Polythiophene DerivativeChenggang Wang, Jon L. Schindler, Carl R. Kannewurf, and Mercouri G. KanatzidisCite this: Chem. Mater. 1995, 7, 1, 58–68Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/cm00049a011https://doi.org/10.1021/cm00049a011research-articleACS PublicationsRequest reuse permissionsArticle Views926Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The PyramidSnapshot Challenge (2019)

In the ideal CS1 classroom, we should understand programming process---how student code evolves over time. However, for graphics-based programming assignments, the task of understanding and grading final solutions, let alone thousands of intermediate steps, is incredibly labor-intensive. In this work, we present a challenge, a dataset, and a promising first solution to autonomously use image output to identify functional, intermediate stages of a student solution. By using computer vision techniques to associate visual output of intermediate student code with functional progress, we supplement a lot of the teacher labor associated with understanding graphics-based, open-ended assignments. We hope our publication of the dataset used in our case study sparks discussion in the community on how to analyze programs with visual program output.
An integrated 0.5 mu m CMOS disposable TiN LDD/salicide spacer technology (2003)

A novel disposable TiN LDD/salicide spacer process has been developed for a 0.5- mu m CMOS technology. Both LDD (lightly doped drain) and salicide definition are obtained using a single disposable TiN spacer. This process results in CMOS devices with low salicided junction leakage, reduced source/drain lateral diffusion, and shallow phosphorus n- and boron p-regions for improved short-channel behavior.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
MicroRNAs targeting prostate cancer stem cells (2015)

Prostate cancer is a frequently diagnosed cancer in males with high mortality in the world. As a heterogeneous tissue, the tumor mass contains a subpopulation that is called as cancer stem cells and displays stem-like properties such as self-renewal, epithelial-mesenchymal transition, metastasis, and drug resistance. Cancer stem cells have been identified in variant tumors and shown to be regulated by various molecules including microRNAs. MicroRNAs are a class of small non-coding RNAs, which can influence tumorigenesis via different mechanisms. In this review, we focus on the functions of microRNAs on regulating the stemness of prostate cancer stem cells with different mechanisms and propose the potential roles of microRNAs in prostate cancer therapy.
신한옥형 공공건축물 활성화를 위한 Barrier-Free인증제도 개선 방안에 관한 연구 (2015)

This study find out problem for Barrier-free certification system when build Neo Han-Ok style public building and seek systematic improvement plan for it. Problem resolution is easy method in architectural field, but it is a temporary expedient. So this study suggest an middle and long-term alternative to analysis legal system.
Convolutional neural network with uncertainty estimates for no-reference image quality assessment (2019)

The use of convolutional neural networks (CNNs) for general no-reference image quality assessment (NR-IQA) has seen tremendous growth in the research community. Most these methods used the patches cropped from the original images for training. For these patch-based methods, the ‘ground truth’ quality of patches is essential. In practice, these methods often took the quality score of an original image directly as the labels of its patches’ quality. However, the perceptual quality of image patches generally differs from the corresponding image quality. Thus, the noise in patches’ labels may hinder effective training of the CNN. In this paper, we propose a CNN with two branches for general noreference image quality assessment. One branch of this model predicts the patch quality, and the other predicts the uncertainty, which denotes the degree of deviation of the patch quality from the image quality. Our model can be trained in an end-to-end manner by minimizing a joint loss. We tested our model on widely used image quality databases and showed that it performed better or comparable with those of state-of-the-art NR-IQA algorithms.
Myeloid <i>Bmal1</i> deletion increases monocyte recruitment and worsens atherosclerosis (2016)

BMAL1, the nonredundant transcription factor in the core molecular clock, has been implicated in cardiometabolic diseases in mice and humans. BMAL1 controls the cyclic trafficking of Ly6c<sup>hi</sup> monocytes to sites of acute inflammation. Myeloid deficiency of <i>Bmal1</i> also worsens chronic inflammation in diet-induced obesity. We studied whether myeloid <i>Bmal1</i> deletion promotes atherosclerosis by enhancing monocyte recruitment to atherosclerotic lesions. By generating <i>Bmal1</i><sup>FloxP/FloxP</sup>;LysM<sup>Cre</sup> mice on the Apoe<sup>-/-</sup> background, we showed that <i>Bmal1</i> deletion in myeloid cells increased the size of atherosclerotic lesions. <i>Bmal1</i> deficiency in monocytes and macrophages resulted in an increased total number of lesional macrophages in general and Ly6c<sup>hi</sup> infiltrating monocyte-macrophages in particular, accompanied by skewed M2 to M1 macrophage phenotype. Ly6c<sup>hi</sup> and/or Ly6c<sup>lo</sup> monocyte subsets in blood, spleen, and bone marrow were not altered. Cell tracking and adoptive transfer of Ly6c<sup>hi</sup> monocytes showed <i>Bmal1</i> deficiency induced more trafficking of Ly6c<sup>hi</sup> monocytes to atherosclerotic lesions, preferential differentiation of Ly6c<sup>hi</sup> monocytes into M1 macrophages, and increased macrophage content and lesion size in the carotid arteries. We demonstrated that <i>Bmal1</i> deficiency in macrophages promotes atherosclerosis by enhancing recruitment of Ly6c<sup>hi</sup> monocytes to atherosclerotic lesions.-Huo, M., Huang, Y., Qu, D., Zhang, H., Wong, W. T., Chawla, A., Huang, Y., Tian, X. Y. Myeloid <i>Bmal1</i> deletion increases monocyte recruitment and worsens atherosclerosis.
Metal Prices in the United States through 1998 (1999)

"Update and revision of a 1993 publication by the USBM, Metal prices in the United States through 1991"--P. iv.
Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sites. (1995)

Human leukemias with 11q23 translocations occur sporadically and after cancer treatment with DNA topoisomerase II-targeted drugs. To investigate this process, we examined DNA topoisomerase II cleavage in vitro in subclones of the normal 11q23 genomic homologue and a t(9;11) translocation breakpoint junction. Cleavage was assayed with limiting dilutions of enzyme in the presence or absence of epipodophyllotoxin and ATP. The strongest sites of cleavage coincided with the t(9;11) breakpoint site and two other translocation breakpoint sites within the normal homologue. These results support the involvement of DNA topoisomerase II in the translocation process at chromosome band 11q23.
Authentication and Authorization in Cyber-Security Frameworks: a Novel Approach for Securing Digital Service Chains (2022)

Digital services and digital service chains are the heart beating of the modern economy. Their composition involves several players, i.e., processes, software, devices, and many kinds of data exchanged among them. In such a scenario, it is important to guarantee data confidentiality, integrity, as well as authentication and authorization procedures between the communicating parties of a service chain. Cyber-security frameworks are explicitly designed for this purpose. They rely on the integration of different software modules, mutually interfaced to accomplish complex security tasks. Nevertheless, it is important to guarantee a high level of protection during data exchange among the modules. Currently, standardized authentication and authorization mechanisms are implemented through proprietary “As-a-Service” products, but the deployment of a mature on-premise solution is still missing. To bridge this gap, this contribution proposes an authentication and authorization module that automatically protects the information flowing among the modules of cyber-security frameworks. It guarantees resource availability only to authenticated subjects. Thus, their operations are confined in what actions they are authorized for. The proposed module has been implemented and tested in a real cyber-security framework under development into the H2020 GUARD project. Experimental tests show that the proposed module enables authentication and authorization procedure delegation among GUARD modules, which eases their implementation, while maximizing the flexibility of the set of access control policies and an efficient protection of the services.
Assessment of a Combined Panel of Six Serum Tumor Markers for Lung Cancer (2015)

The combined assessment of a panel of six serum TMs is a more accurate marker for LC presence than these same TMs considered individually. The potential of these TMs in the diagnostic and screening settings deserves further research.
Gas Adsorption Properties of the Chromium-Based Metal Organic Framework MIL-101 (2009)

MIL-101, a chromium-based metal organic framework, is known to adsorb large amounts of green house gases such as CO2 and CH4. Measurement, analysis, and modeling of the pure gas adsorption isotherms of desired gases are necessary for any attempt to use this framework for separation/storage applications. In an attempt to understand adsorption characteristics of this framework, pure gas adsorption properties of CO2 and CH4 along with C3H8, SF6, and Ar were measured at three temperatures 283, 319, and 351 K using a standard gravimetric method. The adsorbates were chosen based on their physical characteristics such as polarizability and quadrupole moment. Dual site Langmuir (DSL) isotherm proved to be useful for modeling adsorption of gases on this type of materials that are known to have heterogeneity. Active metal centers and sites inside the pores of supertetrahedra act as major locations for adsorption. Analysis of enthalpy of adsorption using the DSL model revealed that, for all gases, it initially decreases with loading and remains constant thereafter. For all gases considered, the enthalpies of adsorption were found to be lower than those on purely siliceous zeolite such as silicalite, suggesting that only moderate interaction exists between the gas and the MIL-101 framework. The enthalpy of adsorption at zero coverage and the logarithm of Henry’s constant were found to be linear functions of polarizability of the adsorbate.