gebhart/patrepeval huggingface dataset:
Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology (2013)

A number of conclusions naturally evolve from the data summarized in this review: (i) melatonin, of both pineal and placental origin, has essential functions in fetal maturation and placenta/uterine homeostasis; (ii) circadian clock genes, which are components of all cells including those in the peripheral reproductive organs, have important roles in reproductive and organismal (fetal and maternal) physiology; (iii) due to the potent antioxidant actions of melatonin, coupled with its virtual absence of toxicity, this indoleamine may have utility in the treatment of pre-eclampsia, intrauterine growth restriction, placental and fetal ischemia/reperfusion, etc. (iv) the propensity for parturition to occur at night may relate to the synergism between the nocturnal increase in melatonin and oxytocin.
3,5‐Dibenzoyl‐4‐(3‐phenoxyphenyl)‐1,4‐dihydro‐2,6‐dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility (2004)

The aim of this study was to investigate the effects of 3,5-diacetyl- (DP1-DP5) and 3,5-dibenzoyl-1,4-dihydropyridines (DP6-DP11) on vascular functions in vitro, by comparing their mechanical and electrophysiological actions in rat aorta rings and single rat tail artery myocytes, respectively, and to quantify their multidrug resistance (MDR)-reversing activity in L5178 Y mouse T-lymphoma cells transfected with MDR1 gene. In rat aorta, the 11 compounds tested, but 3,5-dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7), 3,5-dibenzoyl-4-(3-chlorophenyl)-1,4-dihydro-2,6-dimethylpyridine (DP9), 3,5-dibenzoyl-4-(4-chlorophenyl)-1,4-dihydro-2,6-dimethylpyridine (DP10) and 3,5-dibenzoyl-4-phenyl-1,4-dihydro-2,6-dimethylpyridine (DP11), antagonized 60 mm K+ (K60)-induced contraction in a concentration-dependent manner, with IC50 (m) values ranging between 5.65 x 10(-7) and 2.23 x 10(-5). The 11 dihydropyridines tested, but DP7, inhibited L-type Ca2+ current recorded in artery myocytes in a concentration-dependent manner, with IC50 (M) values ranging between 1.12 x 10(-6) and 6.90 x 10(-5). The K+ -channel opener cromakalim inhibited the Ca2+ -induced contraction in K30 but not that evoked in K60. On the contrary, DP7 was ineffective in both experimental conditions. When the rings were preincubated with 1 mm Ni2+ plus 1 microm nifedipine, the response to phenylephrine was significantly reduced by 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ), a well-known endoplasmic reticulum Ca2+ -ATPase inhibitor. DP7 had no effects on this model system. In L5178 MDR cell line, the 11 dihydropyridines tested, but 3,5-diacetyl-4-(2-nitrophenyl)-1,4-dihydro-2,6-dimethylpyridine (DP1), 3,5-diacetyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP2) and 3,5-diacetyl-4-(3-chlorophenyl)-1,4-dihydro-2,6-dimethylpyridine (DP4), exhibited an MDR-reversing activity, with IC50 values ranging between 3.02 x 10(-7) and 4.27 x 10(-5), DP7 being the most potent. In conclusion, DP7 may represent a lead compound for the development of potent dihydropyridine MDR chemosensitizers devoid of vascular effects. British Journal of Pharmacology (2004) 141, 415-422. doi:10.1038/sj.bjp.0705635
Requirements for personalized user environments in telecommunications (2002)

"The network is the computer" is a vision currently coming true. That "computer", however is characterized by a complexity, chaos, and abundance of information which makes it increasingly difficult for a single (let alone nonexpert) user to efficiently utilize it. We propose an architecture that allows users to have their own personal view of the network, and therefore make "the network their personal computer". In our architecture users can describe their personal working environment (PWE) which will be instantiated on the terminal they are using regardless of the type of terminal equipment or their specific location within the network. This demands that resources in the respective vicinity of the user be considered for inclusion in his/her personal working environment and that the terminal be flexible enough to present different incantations of the same resources in a consistent manner to the user. We describe the components needed for such an architecture and report on a prototype implementation.
Lower bounds on phase sensitivity in ideal and feasible measurements (1994)

The detection of the phase shift between a single mode of the em field and a local reference oscillator is analyzed in the proper framework of quantum estimation theory. Such a fully quantum treatment clarifies the meaning of the ``operational approach'' suggested by Noh, Foug\'eres, and Mandel [Phys. Rev. A 45, 424 (1992)], in which different measurement schemes correspond to different phase operators. We show that the phase shift is actually measured in the form of the polar angle between two real output photocurrents, namely through a joint measurement of two conjugated quadratures of the field. This scheme is the only feasible one for detecting the quantum phase, and it is equivalently performed by either heterodyne detection or double-homodyne detection of the field. On the contrary, the customary homodyne detection (and, generally, any kind of measurement of a single phase-dependent variable) is more properly a zero-point phase measurement. As a definition of sensitivity we consider the output rms noise of the detection scheme, the only relevant one for actual experiments, in contrast with many other different notions currently adopted in the literature. We show that the rms phase sensitivity versus the average photon number n\ifmmode\bar\else\textasciimacron\fi{} is bounded by the ideal limit \ensuremath{\Delta}\ensuremath{\varphi}\ensuremath{\sim}n${\mathrm{\ifmmode\bar\else\textasciimacron\fi{}}}^{\mathrm{\ensuremath{-}}1}$, whereas for the feasible schemes the bound is \ensuremath{\Delta}\ensuremath{\varphi}\ensuremath{\sim}n${\mathrm{\ifmmode\bar\else\textasciimacron\fi{}}}^{\mathrm{\ensuremath{-}}2/3}$, in between the shot-noise level \ensuremath{\Delta}\ensuremath{\varphi}\ensuremath{\sim}n${\mathrm{\ifmmode\bar\else\textasciimacron\fi{}}}^{\mathrm{\ensuremath{-}}1/2}$ and the ideal bound.The latter can acutally be achieved by single homodyne detection of the suitable squeezed states, but only in the neighborhood of a fixed zero-phase working point. The phase sensitivity bound \ensuremath{\Delta}\ensuremath{\varphi}\ensuremath{\sim}n${\mathrm{\ifmmode\bar\else\textasciimacron\fi{}}}^{\mathrm{\ensuremath{-}}2/3}$ can be reached using coherent states with only 2% of squeezing photons, in contrast with the homodyne-detection bound \ensuremath{\Delta}\ensuremath{\varphi}\ensuremath{\sim}n${\mathrm{\ifmmode\bar\else\textasciimacron\fi{}}}^{\mathrm{\ensuremath{-}}1}$ which is reached with 50%. The uncertainty product of two conjugated phase quadratures largely exceeds the Heisenberg limit, even for the ideal joint measurement. We also show that no sizeable improvement in sensitivity is found for detection schemes which involve wideband states, at least for the case of nonentangled states. At the end of the paper we give an extensive table of asymptotic sensitivities at large n\ifmmode\bar\else\textasciimacron\fi{} for both ideal and feasible schemes.
Utilization of a Soft Ionization Mass Spectrometer for Ultra High Sensitivity and Fast Response Emission Measurements (1998)

<div class="htmlview paragraph">The performance of a soft ionization mass spectrometer (MS) has been investigated using nearly one hundred hydrocarbon components and nine inorganic components. Based on a list of typical hydrocarbon emissions from automotive exhaust, synthesized samples have been used to discuss the cross-sensitivity of the target components. The system has been shown to measure hazardous air pollutants (HAPs) such as 1,3-butadiene, benzene and toluene in the vehicle exhaust. As a result, the technique will prove to be very useful in emissions monitoring in the development of low emissions vehicles.</div>
CLINICAL EVALUATION OF LOW DOSE GLUCOCORTICOID THERAPY FOR HORMONE-REFRACTORY PROSTATE CANCER (2000)

Fifteen cases with hormone-refractory metastatic carcinoma of the prostate were treated by the combination therapy of LH-RH analogue and low-dose glucocorticoid. Prior treatments of the patients were composed of maximum androgen blockade (MAB) therapy (14 cases) and bilateral orichiectomy (1 case). Nine of 15 cases underwent estramustine based treatment or anti-cancer chemotherapy as the second-line therapy. As a glucocorticoid (steroid) therapy, 1.5 or 2.0 mg of dexamethasone or 10 mg of predonisolone were given for a median period of nine months. Clinical responses were evaluated by the determination of serum PSA, EOD score and QOL scales. PSA responses were classified as CR, PR and PD according to the following categories; CR : PSA level decreased to less than 2 ng/ml, PR : PSA level decreased to less than half values of pretreatment level, PD: 20% or more increased to pretreatment level. PSA responses (CR + PR) were observed in eight of 15 patients for a median period of six months. Responses are seemed to be correlated with the Gleason scores. No apparent improvement on EOD scores by bone scintigraphy was seen, however, definite improvement of bone pain was identified in eight of 11 cases. The steroid therapy was considered as one of the useful treatment choice for patients with hormone-refractory prostate cancer.
VAR Model for Relations of China's Carbon Productivity and Social Electricity Consumption (2015)

This study was performed to compare effectiveness of two levamisole preparations prepared in two different countries (Iran and Turkey) in mice naturally infected with Aspiculuris tetraptera. For this purpose, natural infection was diagnosed using the cellophane tape method on the perianal region and centrifugal flotation technique on the feces of mice obtained from the experimental Animal Unit of the Faculty of Medicine, University of Yüzüncü Yil, Van. Mice naturally infected with A. tetraptera were then divided in three groups. Animals in Group 1 (8 animals) received levamisole prepared in Iran, animals in Group 2 (8 animals) received levamisole prepared in Turkey and animals in Group 3 (6 animals) were used as untreated controls. Both levamisole preparations were used in a 10 mg/kg dose. After drug administrations, stool samples of the animals in all groups were examined for seven days. On the eighth day, the animals were humanely destroyed using inhalation anesthesia. After euthanasia, parasites in the intestine were also counted. As a result; levamisole coming through uncontrolled border trade from Iran was 69.3% effective against A. tetraptera and the levamisole prepared in Turkey was 91.7% effective in naturally infected mice. Results obtained from this study compared statistically and the differences were found to be significant (p < 0.001).
Novel CSF biomarkers for frontotemporal lobar degenerations (2010)

Clinical cases with FTLD-TDP and FTLD-tau pathology can be potentially identified antemortem by assaying levels of specific analytes that are well-known and readily measurable in CSF.
Induction of xCT gene expression and L-cystine transport activity by diethyl maleate at the inner blood-retinal barrier. (2002)

System x(-)(c)-mediated L-cystine uptake appears to be present at the inner BRB. DEM induces L-cystine transport through system x(-)(c) at the inner BRB by enhanced transcription of the xCT gene.
Identification and characterization of an activated 20S proteasome in <i>Trypanosoma brucei</i> (1997)

Recently, we have reported the isolation and purification of 20S proteasomes from both the procyclic and bloodstream forms of Trypanosoma brucei, but no 26S proteasome was identified under those experimental conditions (Hua et al., Mol. Biochem. Parasitol. (1996) 78, 33-46). Subsequent attempts to identify a 26S proteasome in T. brucei led to the discovery of another form of the 20S proteasome designated the activated 20S proteasome because it exhibited much higher peptidase activities than the original 20S proteasome on all the fluorogenic peptides tested, and it crossreacted with the rabbit antisera against the 20S proteasomes purified from T. brucei. The activated 20S proteasome can be isolated from both procyclic and bloodstream forms of T. brucei and has a slightly higher molecular weight than the 20S proteasome. It is stable in the absence of ATP but susceptible to elution through a DE52 column. Analysis of the activated 20S proteasome in SDS-PAGE showed the presence of all the subunit proteins from the 20S proteasome plus an extra protein with an estimated molecular mass of 26 kDa. This protein, designated PA26, is not a degradation product of the 20S proteasomal subunit proteins. It could be a homolog of the bovine PA28 and human 11S regulator protein which form complexes with the 20S proteasomes resulting in activation of their peptidase activities. This likelihood was confirmed in a reconstitution experiment in which PA26 separated from the proteasome by a DE52 column chromatography was re-introduced into the purified 20S proteasome, and resulted in the emergence of a new protein band with the same mobility and peptidase activities as the activated 20S proteasome in native polyacrylamide gel electrophoresis. The presence of an activated 20S proteasome rather than a homolog of the 26S proteasome in T. brucei suggests that PA26 may play an important role in regulating the proteasome-mediated protein degradations in trypanosomes.
Physicochemical Properties of Surface‐Initiated Polymer Films in the Modification and Processing of Materials (2004)

Abstract This article reviews the physicochemical aspects of surface‐initiated polymer films used to modify planar and non‐planar surfaces and to produce micro‐ and nanoscale patterned features. Particular emphasis is placed on the molecular composition of the polymer and its effect on surface and bulk properties of ultrathin films. Recent advances in the use of responsive polymer films that exhibit dramatically altered properties upon changes in solvent, temperature, or ionic strength are reviewed. The uses of surface‐initiated polymer films to modify materials' properties and impact applications in chromatography, nanoparticle‐templated synthesis, and carbon nanotube dispersion are highlighted.
Average-Value Model of Modular Multilevel Converters Considering Capacitor Voltage Ripple (2016)

The modular multilevel converters (MMCs) are attractive topologies for the high-voltage direct current (HVDC) transmission system. Since the complicated structure of MMC with hundreds sub-modules per arm, building an accurate model to design the appropriate control strategy is one of the main technical challenges. In this paper, the average-value model (AVM) of the MMCs considering the sub-module capacitor voltage ripple is established to explore the control dynamic performance of MMCs. The effect of the sub-module capacitor voltage ripple on the MMC dynamic behavior is explored and the equivalent impedances of the DC and AC sides in the MMC converters are extracted and evaluated. Based on the equivalent impedances, a particular AVM of MMCs, which comprises the equivalent capacitors reflecting the capacitor voltage ripple, is presented. Furthermore, the detailed interaction of the AC side voltages, AC side currents and arm voltages and the coupling relationship of AC output current i <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sub> and i <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">q</sub> can be also precisely described by the introduced AVM. Finally, the effectiveness of the presented model is verified by the PSCAD/EMTDC simulations.
FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells (2011)

Acute lymphoblastic leukemia (ALL), the most common form of childhood cancer, usually responds to chemotherapy but patients who develop disease relapse have a poor prognosis. New agents to treat ALL are urgently required. FTY720 is an immunosuppressive drug that has promising in vitro activity in a number of malignancies, with the proposed mechanism being the reactivation of the protein serine/threonine phosphatase, PP2A. FTY720 reduced the proliferation and viability of Ph(+) and Ph(-) ALL cell lines and patient samples with IC 50 values for viability between 5.3 to 7.9 μM. Cell death was caspase-independent with negligible activation of caspase-3 and no inhibition of FTY720-induced cell death by the caspase inhibitor Z-VAD-FMK. The cytotoxic effects of FTY720 were independent of PP2A reactivation as determined by the lack of effect of the PP2A inhibitor okadaic acid. Features of autophagy, including autophagosomes, LC3II expression and increased autophagic flux, were induced by FTY720. However the phosphorylated form of FTY720 (FTY720-P) similarly induced autophagy but not cell death. This suggests that autophagy is prosurvival in this setting, a finding supported by protection from cell death induced by the cytotoxic agent vincristine. FTY720 also induced reactive oxygen species (ROS) and the antioxidant N-acetyl-cysteine (NAC) partially reversed the cytotoxic effects, demonstrating a role for ROS generation in the cell death mechanism. FTY720 is an active drug in vitro in ALL cell lines and patient samples. Evidence supports a caspase-independent mechanism of cell death with the occurrence of autophagy and necrosis.
Experimental antileukemic agents. Preparation and structure-activity study of S-tritylcysteine and related compounds (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExperimental antileukemic agents. Preparation and structure-activity study of S-tritylcysteine and related compoundsKwang-Yuen Zee-Cheng and Chia-Chung ChengCite this: J. Med. Chem. 1970, 13, 3, 414–418Publication Date (Print):May 1, 1970Publication History Published online1 May 2002Published inissue 1 May 1970https://pubs.acs.org/doi/10.1021/jm00297a019https://doi.org/10.1021/jm00297a019research-articleACS PublicationsRequest reuse permissionsArticle Views411Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Toward unusual aluminum-oxygen compounds. Synthesis and molecular structure of [Al4O(OCH2CF3)11]-: structural characterization of a novel Al4O12 cluster (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTToward unusual aluminum-oxygen compounds. Synthesis and molecular structure of [Al4O(OCH2CF3)11]-: structural characterization of a novel Al4O12 clusterSamuel A. Sangokoya, William T. Pennington, Jameica Byers-Hill, Gregory H. Robinson, and Robin D. RogersCite this: Organometallics 1993, 12, 7, 2429–2431Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/om00031a011https://doi.org/10.1021/om00031a011research-articleACS PublicationsRequest reuse permissionsArticle Views110Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Synthesis of C-ring-functionalized A-ring-aromatic trichothecane analogs (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of C-ring-functionalized A-ring-aromatic trichothecane analogsWayne K. Anderson and George E. LeeCite this: J. Org. Chem. 1980, 45, 3, 501–506Publication Date (Print):February 1, 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://pubs.acs.org/doi/10.1021/jo01291a026https://doi.org/10.1021/jo01291a026research-articleACS PublicationsRequest reuse permissionsArticle Views201Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Impaired spatial memory in aged rats is associated with alterations in inositol phospholipid metabolism (1994)

WE have investigated changes in inositol phospholipid turnover and membrane arachidonic acid concentration in the dentate gyrus and frontal cortex of animals aged 3-6 months, 14 months or 22 months which were trained in the Morris water maze. Ageing was associated with poorer performances in the behavioural test, characterized by increased variability in retention and acquisition amongst individuals, a decrease in membrane arachidonic acid concentration and increased unstimulated inositol phospholipid metabolism in synaptosomes prepared from frontal cortex and dentate gyrus. Arachidonic acid stimulated inositol phospholipid metabolism in synaptosomes, but in the older groups, stimulation was associated with good performance in the Morris water maze. In slices prepared from frontal cortex, responsiveness of inositol phospholipid metabolism to glutamate was also age- and performance-dependent. The findings highlight a correlation between age, inositol phospholipid metabolism and performance in the Morris water maze.