gebhart/patrepeval huggingface dataset:
Full spectrum combining of staggered-QPSK signals (2002)

Several antenna diversity techniques can be used at base stations (BS) to enhance the reliable transmission of signals from a "weak" single source. The services which can benefit from antenna arraying include the planned Motorola's Iridium, power-limited satellites, and NASA's next generation all digital receiver. A full spectrum combining (FSC) system is proposed for coherent staggered-QPSK (SQPSK) signaling and its performance is analyzed assuming imperfect carrier and symbol timing recovery. In order to align the signals for an array of L antennas, the combining system utilizes L-1 differential phase estimators. Each one of these phase difference estimators is shown to be an open loop maximum likelihood estimator (MLE). The performance of this estimator is derived and the variance of the estimate error is compared to the Cramer-Rao lower bound (CRLB). Next, the performance of this FSC technique is quantified based on the bit error rate loss. The results are verified by simulation for a scenario of two identical base stations arrayed together. The calculated and measured gain when operating at a data rate of 16 kbps and a BER of 10/sup -3/ is 2.8 dB, compared to the ideal (i.e., no losses due to combining or imperfect references) gain of 3 dB in this case.
Kinetics and modeling of reductive dechlorination at high PCE and TCE concentrations (2004)

Two biokinetic models employing the Michaelis-Menten equation for anaerobic reductive dechlorination of tetrachloroethylene (PCE) and trichloroethylene (TCE) were developed. The models were compared with results from batch kinetic tests conducted over a wide range of PCE and TCE concentrations with two different dechlorinating cultures. One model applies Michaelis-Menten kinetics with competitive inhibition among chlorinated aliphatic hydrocarbons (CAHs), while the other model includes both competitive inhibition and Haldane inhibition at high CAH concentrations. Model simulations with competitive inhibition simulated the experimental results well for PCE concentrations lower than 300 microM. However, simulations deviated from the experimental observations for PCE or TCE concentrations greater than 300-400 microM. The kinetic model that incorporated both competitive and Haldane inhibitions better simulated experimental data for PCE concentrations near the solubility limit (1000 microM), and TCE concentrations at half its solubility limit (4000 microM). Based on the modeling analysis of the experimental results, the PM culture (Point Mugu, CA) had very high Haldane inhibition constants for cis-1,2-dichlororethylene (c-DCE) and vinyl chloride (VC) (6000 and 7000 microM, respectively), indicating very weak Haldane inhibition, while the EV culture (the Evanite site in Corvallis, OR) had lower Haldane inhibition constants for TCE, c-DCE, and VC of 900, 750, and 750 microM, respectively. The BM culture (a binary mixed culture of the PM and EV cultures) had transformation abilities that represented the mixture of the EV and PM cultures. Model simulations of the BM culture transformation abilities were well represented by separate rate equations and model parameters for the two independent cultures that were simultaneously solved. Modeling results indicated that a combination of competitive and Haldane inhibition kinetics is required to simulate dechlorination over a broad range of concentrations up to the solubility limit of PCE and half the solubility limit of TCE.
Functional Interaction of Mammalian Valyl-tRNA Synthetase with Elongation Factor EF-1α in the Complex with EF-1H (1999)

In mammalian cells valyl-tRNA synthetase (ValRS) forms a high Mr complex with the four subunits of elongation factor EF-1H. The beta, gamma, and delta subunits, that contribute the guanine nucleotide exchange activity of EF-1H, are tightly associated with the NH2-terminal polypeptide extension of valyl-tRNA synthetase. In this study, we have examined the possibility that the functioning of the companion enzyme EF-1alpha could regulate valyl-tRNA synthetase activity. We show here that the addition of EF-1alpha and GTP in excess in the aminoacylation mixture is accompanied by a 2-fold stimulation of valyl-tRNAVal synthesis catalyzed by the valyl-tRNA synthetase component of the ValRS.EF-1H complex. This effect is not observed in the presence of EF-1alpha and GDP or EF-Tu.GTP and requires association of valyl-tRNA synthetase within the ValRS.EF-1H complex. Since valyl-tRNA synthetase and elongation factor EF-1alpha catalyze two consecutive steps of the in vivo tRNA cycle, aminoacylation and formation of the ternary complex EF-1alpha.GTP. Val-tRNAVal that serves as a vector of tRNA from the synthetase to the ribosome, the data suggest a coordinate regulation of these two successive reactions. The EF-1alpha.GTP-dependent stimulation of valyl-tRNA synthetase activity provides further evidence for tRNA channeling during protein synthesis in mammalian cells.
Real-time ML estimation of very frequency selective multipath channels (2002)

It is shown that the inverse filter is a good solution for estimating multipath channels when using binary sequences as the input signal. It is a maximum-likelihood estimator which enables the utilization of aperiodic sequences (bursts). Therefore, it is well suited for estimating very-frequency-selective channels. Since the channel is only occupied during short time intervals, it maintains compatibility with other services when measuring in occupied frequency bands. A practical realization shows that inverse-filter-based estimation techniques are well suited for implementing real-time channel sounders. The inverse filter is realized in SAW (surface acoustic wave) techniques. The implementation loss of 2.5 to 3.5 dB for the POP (peak/off peak) ratio shows that its realization is not particularly critical. The sounder estimates either full impulse responses or statistical parameters at a rate of 9 or 2.2 impulse responses per second, respectively. Relevant parameters characterizing the mobile radio channel are proposed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Motion pictures on in-situ air bearing dynamics (1986)

Knowledge of the detailed motion of an air bearing slider as it "flys" over the surface of a recording disk is essential for understanding and improving the slider-disk interface. The minute spacing between these surfaces (0.2 µM) permits the use of electrical capacitance for obtaining absolute flying height, pitch and roll of the slider relative to the disk surface. Employing special multi-sensor air bearing sliders in an assembled disk file, along with high bandwidth electronics and microsecond data acquisition, its motion can be captured and reconstructed. The results are visualized in a motion picture format, showing the behavior of the slider in slow motion during an entire full data band access stroke. No large excursions of the slider's motion are found even when it experiences a large radial acceleration during accessing.
Abstract C14: Squamous non-small cell lung cancer (NSCLC-SCC) patient-derived xenografts (PDX) from Asian patients have high response rate (RR) to cetuximab than those of adenocarcinoma. (2013)

Abstract Cetuximab was approved for advanced colorectal carcinoma (CRC), but yet for NSCLC, although some trials [e.g. FLEX (1) and BMS099 (2)] demonstrated benefit in subsets of patients. Recent retrospective study on Caucasian patients among the FLEX study cohort revealed that high EGFR expressors, uniquely defined by high-IHC score, are likely to benefit from the treatment (3). In particular, this was confirmed in a 50-patient derived xenografts model trial, mouse clinical trial (MCT or “Patient Avatar Trial”), in a similar format of FLEX, first time demonstrating relevance of human trial and MCT. The goal of the present study is identify the subset of Asian NSCLC patients that respond to cetuximab in a MCT. We have established a large panel of PDXs from NSCLC Asian patients of different histology (4): squamous cell carcinoma (SCC), adenocarcinoma (ADC), pleiomorphic carcinoma (PLC), and large cell carcinoma (LCC). We tested cetuximab activity in a randomly selected 32 PDX in a MCT. While NSCLC had overall engraftment rate of 25%, SCC interestingly, had higher rate of ∼31%, near-double ∼17% of ADC, which may have metastasis and prognosis implications. A subset of PDXs were found to respond to cetuximab (10/32) (31%, defined by %ΔT/ΔC &lt; 25%). Surprisingly, all 10 responders exclusively belong to SCC and PLC (9/10 and 1/10 respectively), contrasting none to ADC (0/10). Non-/poor-responders (%ΔT/ΔC &gt; 25%) include ADC (7/22), LCC (2/22) and SCC (12/22). Among the 12 non-/poor-responsive SCC, one has KRAS-G12D mutation, one has ALK-EML4 fusion and one has c-MET gene amplification. Among the SCC responders are ones with activating EGFR mutations. SCC has strikingly higher cetuximab response rate (RR) than ADC, with possible positive factors of EGFR mutation and negative factors of KRAS mutation, ALK fusion and c-met amplification. If proven true clinically, cetuximab could become a new therapy for NSCLC-SCC. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):C14. Citation Format: Mengmeng Yang, Jie Cai, Sheng Guo, Xuesong Huang, Jie Yang, Xiaoming Song, Dawei Chen, Likun Zhang, Jiahua Jiang, Jean-Pierre Wery, Henry Li. Squamous non-small cell lung cancer (NSCLC-SCC) patient-derived xenografts (PDX) from Asian patients have high response rate (RR) to cetuximab than those of adenocarcinoma. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C14.
A New Reaction of Nitriles. I. Amides from Alkenes and Mononitriles<sup>1</sup> (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Reaction of Nitriles. I. Amides from Alkenes and Mononitriles1John J. Ritter and P. Paul MinieriCite this: J. Am. Chem. Soc. 1948, 70, 12, 4045–4048Publication Date (Print):December 1, 1948Publication History Published online1 May 2002Published inissue 1 December 1948https://pubs.acs.org/doi/10.1021/ja01192a022https://doi.org/10.1021/ja01192a022research-articleACS PublicationsRequest reuse permissionsArticle Views4665Altmetric-Citations529LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A hybrid reverberation crossfading technique (2010)

Hybrid reverberators combine convolutional and feedback delay network (FDN) reverberators to exactly reproduce the psycoacoustically important reverberation impulse response onset while efficiently generating the needed late-field characteristics. A simple method for crossfading between the convolutional and FDN components of a hybrid reverberation is presented. It involves forming the convolutional impulse response as the windowed difference between the desired and FDN impulse responses. In this way, arbitrary windows may be applied to the convolution and FDN components of the hybrid reverberator impulse response in forming the cross-fade. For applications in which the impulse response onset depends on a parameter, a singular value decomposition is used to develop a low-rank approximation to the tabulated reverberation impulse response onsets. The approximation is the combination of a few fixed impulse responses, with parameter-dependent weights. An emulation of the EMT 140 plate reverberator is presented as a sample application.
Cbl-b Positively Regulates Btk-mediated Activation of Phospholipase C-γ2 in B Cells (2002)

Genetic studies have revealed that Cbl-b plays a negative role in the antigen receptor-mediated proliferation of lymphocytes. However, we show that Cbl-b-deficient DT40 B cells display reduced phospholipase C (PLC)-gamma2 activation and Ca2+ mobilization upon B cell receptor (BCR) stimulation. In addition, the overexpression of Cbl-b in WEHI-231 mouse B cells resulted in the augmentation of BCR-induced Ca2+ mobilization. Cbl-b interacted with PLC-gamma2 and helped the association of PLC-gamma2 with Bruton's tyrosine kinase (Btk), as well as B cell linker protein (BLNK). Cbl-b was indispensable for Btk-dependent sustained increase in intracellular Ca2+. Both NH(2)-terminal tyrosine kinase-binding domain and COOH-terminal half region of Cbl-b were essential for its association with PLC-gamma2 and the regulation of Ca2+ mobilization. These results demonstrate that Cbl-b positively regulates BCR-mediated Ca2+ signaling, most likely by influencing the Btk/BLNK/PLC-gamma2 complex formation.
TOPS: new DOA estimator for wideband signals (2006)

This paper introduces a new direction-of-arrival (DOA) estimation algorithm for wideband sources called test of orthogonality of projected subspaces (TOPS). This new technique estimates DOAs by measuring the orthogonal relation between the signal and the noise subspaces of multiple frequency components of the sources. TOPS can be used with arbitrary shaped one-dimensional (1-D) or two-dimensional (2-D) arrays. Unlike other coherent wideband methods, such as the coherent signal subspace method (CSSM) and WAVES, the new method does not require any preprocessing for initial values. The performance of those wideband techniques and incoherent MUSIC is compared with that of the new method through computer simulations. The simulations show that this new technique performs better than others in mid signal-to-noise ratio (SNR) ranges, while coherent methods work best in low SNR and incoherent methods work best in high SNR. Thus, TOPS fills a gap between coherent and incoherent methods.
Characterizing Privacy Risks of Mobile Apps with Sensitivity Analysis (2017)

Given the emerging concerns over app privacy-related risks, major app distribution providers (e.g., Microsoft) have been exploring approaches to help end users to make informed decision before installation. This is different from existing approaches of simply trusting users to make the right decision. We build on the direction of risk rating as the way to communicate app-specific privacy risks to end users. To this end, we propose to use sensitivity analysis to infer whether an app requests sensitive on-device resources/ data that are not required for its expected functionality. Our system, Privet, addresses challenges in efficiently achieving test coverage and automated privacy risk assessment. Finally, we evaluate Privet with 1,000 Android apps released in the wild.
Neutrophil Adhesion Molecule Expression in Familial Mediterranean Fever: Discordance between the Intravascular Regulation of β2 Integrin and L-Selectin Expression in Acute Attack (2004)

beta2 Integrin is up-regulated during an acute attack of FMF in dissociation with LS expression, suggesting a unique nonchemoattractant-mediated neutrophil activation.
Formation of the interface between GaAs and Si: Implications for GaAs-on-Si heteroepitaxy (1987)

Results of photoemission core-level spectroscopy measurements for coverages of around one monolayer of As, Ga, and GaAs on Si substrates are presented. The interfaces were formed on on-axis Si(100) and Si(111) substrates using molecular beam epitaxy techniques. The bonding between As and the substrate surface leaves the As atoms fully coordinated and thus extremely unreactive. This causes the GaAs films to form islands at average coverages of less than one monolayer. The surface between the islands is found to be terminated by a single atomic layer of As. Use of a Ga predeposition technique shows evidence of decreasing the area between islands. Results for As interaction with stepped Si(100) surfaces and the implications for avoidance of antiphase domain boundaries are discussed.
RETROACTIVE STUDY IN 524 PATIENTS ON THE APPLICATION OF THE 830 nm GaAiAs DIODE LASER IN LOW REACTIVE-LEVEL LASER THERAPY (LLLT) FOR LUMBAGO (1992)

From 1983, out of 4500 pain patients treated at the Ohshiro clinic, 1500 had lumbago-related disease entities. From 1987 until the present, a period of 61 months, 524 patients with a variety of lumbar diseases received low reactive-level laser therapy, LLLT, using the GaAlAs diode laser (830 nm, 60 mW, continuous wave). There were 364 males and 160 females (M:F-2.3:1), with an average age of 53.7 years (M: 53.7, F: 47.5). The laser was applied in the pressure contact technique at a variety of treatment times, using Ohshiro's proximal priority method. The patients graded the effectiveness of their therapy into four grades, from excellent to poor: the sum of the first two grades was used to assess the overall efficacy rate. Patients were interviewed immediately before and after the first therapy session, to give the immediate effect, and at one week after the final session, to elucidate the delayed LLLT effect. Some of the patients (81.6%) reported excellent or good immediate results, and 82% gave the same assessment for the delayed effect. No side-effects at all were reported, and patients have maintained the effective results during the follow-up period. The authors conclude that LLLT with the GaAlAs diode laser at the parameters as reported affords an easily applied, noninvasive, effective and safe therapeutic method for the treatment of pain entities in the lumbago group. Further controlled studies are needed to research in detail the possible mechanisms and pathways, although some are already known.
A Time-Domain Impedance Probe for Fast Measurements of Electron Plasma Parameters in the Ionosphere (2019)

A new time-domain impedance probe is presented in this paper. The new instrument is able to make measurements of absolute electron density and electron-neutral collision frequency in the ionosphere at temporal and spatial resolutions not previously attained. A single measurement is made in 100μs, which yields an instantaneous spatial resolution of 0.1 m for sounding rocket experiments. A prototype of this instrument was integrated into the payload of a NASA Undergraduate Student Instrument Program sounding rocket launched out of Wallops Island on March 1, 2016. Here, we describe the instrument, and present the data obtained from the sounding rocket experiment. A 6-V amplitude Gaussian derivative excitation was applied to a dipole probe structure, and the current through the probe terminals measured with a balanced active bridge circuit. The time-domain current response was sampled at 5 MS/s, at 12-bit resolution. In the course of the flight, the instrument measured a highly nonlinear response of the plasma because of the large input voltage signal applied. The linear theory cannot explain this response, which obscured interpretation of the data. As a result, we used time- and frequency-domain trend analysis to obtain the variation of electron density over the upleg and downleg of the rocket trajectory. The obtained time and fast Fourier transform trends showed enhanced electron densities in the F layer, which confirmed that the instrument was able to measure the density variations during a significant portion of the flight.
Laplacian Support Vector Machines Trained in the Primal (2009)

In the last few years, due to the growing ubiquity of unlabeled data, much effort has been spent by the machine learning community to develop better understanding and improve the quality of classifiers exploiting unlabeled data. Following the manifold regularization approach, Laplacian Support Vector Machines (LapSVMs) have shown the state of the art performance in semi--supervised classification. In this paper we present two strategies to solve the primal LapSVM problem, in order to overcome some issues of the original dual formulation. Whereas training a LapSVM in the dual requires two steps, using the primal form allows us to collapse training to a single step. Moreover, the computational complexity of the training algorithm is reduced from O(n^3) to O(n^2) using preconditioned conjugate gradient, where n is the combined number of labeled and unlabeled examples. We speed up training by using an early stopping strategy based on the prediction on unlabeled data or, if available, on labeled validation examples. This allows the algorithm to quickly compute approximate solutions with roughly the same classification accuracy as the optimal ones, considerably reducing the training time. Due to its simplicity, training LapSVM in the primal can be the starting point for additional enhancements of the original LapSVM formulation, such as those for dealing with large datasets. We present an extensive experimental evaluation on real world data showing the benefits of the proposed approach.
THE CLINICAL EVALUATION OF OVARIAN RESPONSES TO GONADOTROPIC THERAPY (1939)

Journal Article THE CLINICAL EVALUATION OF OVARIAN RESPONSES TO GONADOTROPIC THERAPY Get access E. C. HAMBLEN E. C. HAMBLEN M.D. Search for other works by this author on: Oxford Academic Google Scholar Endocrinology, Volume 24, Issue 6, 1 June 1939, Pages 848–866, https://doi.org/10.1210/endo-24-6-848 Published: 01 June 1939
Prevention of Peritoneal Adhesions with Aprotinin (Trasylol) (1976)

An objective assessment of intraperitoneal trasylol in the prevention of abdominal adhesions in 20 patients has shown that Trasylol resulted in a marked reduction in adhesions in 16 patients who underwent 'second look' procedures. No side-effects were noted and all wounds healed without complications.
A systematic and physical application of multivariate statistics to MOSFET I-V models (2003)

A statistical method applicable to MOSFET compact models for circuit simulation is proposed. A salient feature of the method is that correlation between device parameters is formulated by independent physical parameters which dominate MOSFET characteristics. The key idea is the introduction of an intermediate model. With the use of the intermediate model, physical parameter fluctuations are systematically mapped into the parameters of many device models. As the device parameters are expressed as functions of the independent physical parameters, the worst-case parameters can be accurately derived from the statistical model. The efficiency of the proposed method is shown with experimental results from a 0.3 /spl mu/m CMOS processing technology.