gebhart/patrepeval huggingface dataset:
A phase I, pharmacokinetic (PK), and pharmacodynamic (PD) study of the farnesyl transferase inhibitor (FTI) R115777 in combination with weekly paclitaxel in patients (pts) with advanced solid cancers (2004)

3136 Background: R115777 (tipifarnib, ZARNESTRA), an oral methyl quinolinone selectively inhibits farnesyl transferase, a critical enzyme in several cell signal transduction pathways. The preclinical synergism of FTIs with taxanes and the antitumor activity of R115777 in breast cancer provided the rationale for evaluating this regimen. Methods: Pts received escalating doses of weekly paclitaxel (1 hr on days 1, 8 & 15 every 4 weeks) and a fixed dose of R115777 (200 mg po BID) administered for 21 days followed by 7 days rest. This study also sought to evaluate whether inhibition of protein farnesylation could be detected using the chaperone protein HDJ2 as a PD surrogate of effect in peripheral blood mononuclear cells (PBMCs). Results: Thus far, 15 pts stratified by prior myelotoxic therapy into heavily (HP) and lightly pretreated (LP) cohorts (median age 57 [range 32–77], males/females-5/10) have received a total of 75 courses [range 1–14 per pt] at dosages of 60, 75, 80 and 90 mg/m2 of paclitaxel. At 90 mg/m2 of paclitaxel DLTs occurred in 2 HP pts (febrile neutropenia, grade 3 diarrhea/fatigue) and in 1 LP pt (febrile neutropenia). Non-dose-limiting neutropenia (grade 3), stomatitis, fatigue, diarrhea, and rash, have also been observed. Preliminary PK analysis of paclitaxel (with/without R115777) in 8 pts at 60 and 75 mg/m2 shows no significant difference in Cmax or AUC, when performing a paired analysis of individual pt parameters. The mean trough R115777 concentration following repeated doses was 211 ng/mL. The proportion of unfarnesylated HDJ2 increased with treatment in 5/5 evaluable pts at 75 and 90 mg/m2 of paclitaxel. Two HP pts (1 with breast, 1 with squamous cell skin cancer) remain on study with stable disease (SD) at 14 and 8 courses, respectively. Further treatment of HP/LP pts continues at 80 mg/m2 and 90 mg/m2of paclitaxel, respectively. Conclusions: The combination of R115777 and paclitaxel appears safe and feasible, with biologically relevant concentrations of R115777 and evidence of consistent inhibition of protein farnesylation in PBMCs. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Johnson and Johnson Pharmaceutical Research and Development Johnson and Johnson Pharmaceutical Research and Development Johnson and Johnson Pharmaceutical Research and Development Johnson and Johnson Pharmaceutical Research and Development
Broadband Wide Angle Lens Implemented with Dielectric Metamaterials (2011)

The Luneburg lens is a powerful imaging device, exhibiting aberration free focusing for parallel rays incident from any direction. However, its advantages are offset by a focal surface that is spherical and thus difficult to integrate with standard planar detector and emitter arrays. Using the recently developed technique of transformation optics, it is possible to transform the curved focal surface to a flat plane while maintaining the perfect focusing behavior of the Luneburg over a wide field of view. Here we apply these techniques to a lesser-known refractive Luneburg lens and implement the design with a metamaterial composed of a semi-crystalline distribution of holes drilled in a dielectric. In addition, we investigate the aberrations introduced by various approximations made in the implementation of the lens. The resulting design approach has improved mechanical strength with small aberrations and is ideally suited to implementation at infrared and visible wavelengths.
A road surface freezing model using heat, water and salt balance and its validation by field experiments (2014)

This study aims at helping optimize the application of deicing agents on the winter road surface. In this regard, field tests were conducted for observing how water and deicing agents (= salt) disperse due to passing vehicles as well as for calculating the dissolution rates of salt on the road surface. Additionally, we developed a one-dimensional time-dependent model for the prediction of freezing on a road surface. It takes into account the effects of salting and passing vehicles and is called the RSF-SV model. Its validity was examined by using field test results. Based on the test results, the relationship between the amount of water dispersed due to passing vehicles and the thickness of the water film on the surface was formulated, and the dissolution rate of salt on the icy road surface was identified. The RSF-SV model used these results for successfully reproducing the time-series changes in the surface temperature, the ice film thickness, the water film thickness, the salt concentration, and the amount of residual salt on the ice-covered road surface after the application of deicing agents.
Equine infectious anemia virus derived from a molecular clone persistently infects horses (1990)

A full-length molecular clone of equine infectious anemia virus (EIAV) was isolated from a persistently infected canine fetal thymus cell line (Cf2Th). Upon transfection of equine dermis cells, the clone, designated CL22, yielded infectious EIAV particles (CL22-V) that replicated in vitro in both Cf2Th cells and an equine dermis cell strain. Horses infected with CL22-V developed an antibody response to viral proteins and possessed viral DNA in peripheral blood mononuclear cells, as determined by polymerase chain reaction assays. In addition, horses infected with CL22-V became persistently infected and were capable of transmitting the infection by transfer of whole blood to uninfected horses. However, CL22-V, like the parental canine cell-adapted virus, did not cause clinical signs in infected horses. Reverse transcriptase assays of CL22-V- and virulent EIAV-infected equine mononuclear cell cultures indicated that the lack of virulence of CL22-V was not due to an inability to infect and replicate in equine mononuclear cells in vitro.
Optimal tile size adjustment in compiling general DOACROSS loop nests (1995)

In practical problems, such as the relaxation methods used
Synthesis of MgB/sub 2/ by exposure of polycrystalline boron to magnesium vapor (2003)

Polycrystalline boron in lump form was reacted with magnesium vapor inside steel tubes at 900 C to produce MgB/sub 2/ using four to five times the stoichiometric requirement of Mg. The boron lumps were encased inside Ta foil folded over to form a boat to isolate them from the liquid Mg. These materials were sealed inside steel tubes by arc welding. Reactions were allowed to proceed for times ranging from 2.5 to 837 hours. Upon opening a tube after a 42-hour reaction time a gray powder was removed which X-ray diffraction indicated was MgB/sub 2/. SEM examination of the surfaces of the powder particles revealed a dense layer of 1-2 micron diameter crystallites which appear to be small plates with hexagonal symmetry. Metallographic examination of sections cut through the particles indicated the presence of a significant volume fraction of unreacted boron. The reaction appears to have proceeded initially along the grain boundaries in the polycrystalline lumps breaking them up into particles corresponding to the grain size. Magnetic susceptibility measurements on the powder and resistivity measurements on a cold pressed pellet show a sharp transition at 39 K despite the presence of unreacted boron. Even after reaction times up to 837 hours there was still a significant amount of unreacted boron.
Class-specific grasping of 3D objects from a single 2D image (2010)

Our goal is to grasp 3D objects given a single image, by using prior 3D shape models of object classes. The shape models, defined as a collection of oriented primitive shapes centered at fixed 3D positions, can be learned from a few labeled images for each class. The 3D class model can then be used to estimate the 3D shape of a detected object, including occluded parts, from a single image. The estimated 3D shape is used as to select one of the target grasps for the object. We show that our 3D shape estimation is sufficiently accurate for a robot to successfully grasp the object, even in situations where the part to be grasped is not visible in the input image.
Some Chemotherapeutically Active Sulfones.<sup>1</sup> I (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Chemotherapeutically Active Sulfones.1 IL. L. BambasCite this: J. Am. Chem. Soc. 1945, 67, 4, 668–670Publication Date (Print):April 1, 1945Publication History Published online1 May 2002Published inissue 1 April 1945https://doi.org/10.1021/ja01220a049RIGHTS & PERMISSIONSArticle Views120Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (370 KB) Get e-Alerts Get e-Alerts
Antiapoptotic Actions of Methyl Gallate on Neonatal Rat Cardiac Myocytes Exposed to H<sub><b>2</b></sub>O<sub><b>2</b></sub> (2014)

Reactive oxygen species trigger cardiomyocyte cell death via increased oxidative stress and have been implicated in the pathogenesis of cardiovascular diseases. The prevention of cardiomyocyte apoptosis is a putative therapeutic target in cardioprotection. Polyphenol intake has been associated with reduced incidences of cardiovascular disease and better overall health. Polyphenols like epigallocatechin gallate (EGCG) can reduce apoptosis of cardiomyocytes, resulting in better health outcomes in animal models of cardiac disorders. Here, we analyzed whether the antioxidant N-acetyl cysteine (NAC) or polyphenols EGCG, gallic acid (GA) or methyl gallate (MG) can protect cardiomyocytes from cobalt or H2O2-induced stress. We demonstrate that MG can uphold viability of neonatal rat cardiomyocytes exposed to H2O2 by diminishing intracellular ROS, maintaining mitochondrial membrane potential, augmenting endogenous glutathione, and reducing apoptosis as evidenced by impaired Annexin V/PI staining, prevention of DNA fragmentation, and cleaved caspase-9 accumulation. These findings suggest a therapeutic value for MG in cardioprotection.
Fabrication and characterization of co-sputtering Au/SiO<inf>2</inf> thin films prepared by RF magnetron sputtering (2010)

An amorphous silicon suboxide was synthesized by co-sputtering of Au and SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> using RF magnetron sputtering. The extracted data from XRD, SEM as well as EDX were utilized to characterize the surface of the thin film samples.
Secure Distributed Backup: Erasure Codes and Anonymous Message Delivery (2007)

We address the problem of backing up one's important data files in an efficient, secure and robust manner by suggesting that copies of such files be sent to untrusted remote peers over the Internet. To provide incentive for such peers to store copies of your files, you would be required to devote some of your surplus disk space to storing copies of their files. In this manner, your data would be distributed widely about the planet and would thus be immune to loss due to all but the most global of disasters. We address a few of the major challenges that must be overcome to make such a network a reality. First, we note that since remote peers are inherently unreliable, your data files must have some form a redundancy introduced to ensure complete recovery when needed; however, since wholesale replication of the files is neither space nor bandwidth efficient, we suggest the use of an erasure correcting code. We evaluate the use of a few existing codes for this task (Chapters 2 and 3) and propose a new class of codes, called windowed erasure codes, which aim to minimize time complexity while maintaining the greatest probability of successful recovery (Chapter 4). To help ensure the security of one's data and to avoid the problem of an adversary engaging in a selective denial of service attack against a single participant, we propose the use of an anonymous message delivery technique for distributing file data (Chapter 6). The protocol we propose aims to be efficient in its use of network bandwidth while remaining secure in the face of clients who choose to collude against the others. Also, as a II necessary primitive, we develop a multiparty protocol for generating secret permutations (Chapter 5). Finally, a practical backup application will require a method of encoding a hierarchy of files and the changes to those files over time into a sequence of fixed length blocks to be used with the above protocols. For this, we propose an algorithm based on a rolling checksum which is capable of identifying and removing redundant blocks of data located anywhere within a directory hierarchy (Chapter 7).
A somatic <i>NLRP3</i> mutation as a cause of a sporadic case of chronic infantile neurologic, cutaneous, articular syndrome/neonatal‐onset multisystem inflammatory disease: Novel evidence of the role of low‐level mosaicism as the pathophysiologic mechanism underlying mendelian inherited diseases (2010)

Our findings identify the novel p.D303H NLRP3 variant in a Spanish patient with CINCA/NOMID as a new disease-causing mutation, which was detected as a somatic, nongermline mutation in hematopoietic and nonhematopoietic cell lineages. Our data provide new insight into the role of low-level mosaicism in NLRP3 as the pathophysiologic mechanism underlying cryopyrin-associated periodic syndrome.
Investigation on the electric arc light emission in TIG welding (2007)

It has been presented the results of investigation spectrum of the electric arc light. The main goal of these researches was to check that welding arc light can be seen as a signal carrying essential information about the welding process and exploiting in the monitoring of the welding process. Designed and made experimental station. The advanced spectrophotometer was used to data acquisition of spectrum of arc light. The investigations were conducted on the automated TIG welding station. For each welding parameter the arc light spectrum was measured. Research results presented in this paper indicate that the welding arc light emission contains a lot of information concerning the course of the welding process. That signal is much more sensitive than the signals recorded in the electric circuit of the welding arc to the changes of welding conditions and should be used as a tool for monitoring of the TIG welding process. Spectrophotometer is based on reflection grating and CCD array with 1028 elements (pixels) in the visible spectral range of 340 to 860 nm. It is an expensive instrument and that can be used only as a complementary tool in sensing of welding processes. The investigation results are indicative of the next steps of researches on the welding arc radiation phenomenon and the possibilities of using this signal for online sensing of the welding process on fully automated and robotised stands. This monitoring system will be particularly attractive for welded-structures manufacturing industry because it could significantly reduce the cost for post weld analysis and repairs. Quite new approach to monitoring of welding processes replaces 'trough the arc methods' of monitoring by non-conventional methods. Three fitting functions: Lorentz, Gauss and Voight were investigated as a means to simulate the spectrum distribution of the electric arc light. The mathematical-physical model of the arc light emission and neural networks were compared. [Received 15 November 2006; Accepted 13 March 2007]
Estimating overpressures in pole-type distribution transformers. I. Tank withstand evaluation (2003)

When an electric arc is generated in transformer oil, a strong overpressure may rapidly develop in the tank, especially for low-impedance faults. This paper presents the test method and results obtained in a project aimed at assessing the human and environmental risks associated with this type of fault. Limit energy and pressure values were defined in terms of different safety levels. The best method of limiting the energy and pressure at a safety level in the transformer tank during internal faults of greater than 1.7 kA is to protect the transformer with a current limiting fuse. Other ways to increase the mechanical withstand of transformer tanks under such faults are also discussed.
A Built for Purpose Micro-Hole Coiled Tubing Rig (MCTR) (2007)

This report will serve as the final report on the work performed from the contract period October 2005 thru April 2007. The project 'A Built for Purpose Microhole Coiled Tubing Rig (MCTR)' purpose was to upgrade an existing state-of-the-art Coiled Tubing Drilling Rig to a Microhole Coiled Tubing Rig (MCTR) capable of meeting the specifications and tasks of the Department of Energy. The individual tasks outlined to meet the Department of Energy's specifications are: (1) Concept and development of lubricator and tool deployment system; (2) Concept and development of process control and data acquisition; (3) Concept and development of safety and efficiency improvements; and (4) Final unit integration and testing. The end result of the MCTR upgrade has produced a unit capable of meeting the following requirements: (1) Capable of handling 1-inch through 2-3/8-inch coiled tubing (Currently dressed for 2-3/8-inch coiled tubing and capable of running up to 3-1/2-inch coiled tubing); (2) Capable of drilling and casing surface, intermediate, production and liner hole intervals; (3) Capable of drilling with coiled tubing and has all controls and installation piping for a top drive; (4) Rig is capable of running 7-5/8-inch range 2 casing; and (5) Capable of drilling 5,000 ft true vertical depth (TVD) and 6,000 ft true measured depth (TMD).
Distribution of Integrin Cell Adhesion Receptors on Normal Bronchial Epithelial Cells and Lung Cancer Cells <i>In Vitro</i> and <i>In Vivo</i> (1993)

The interactions of bronchial epithelial cells with the basement membrane control cell morphology, differentiation, and proliferation in addition to having a major role in malignant transformation. Since these interactions are mediated by the integrin family of cell adhesion receptors, we characterized the integrin repertoire and adhesive properties of normal human bronchial epithelial cells in culture and cell lines derived from nine lung carcinomas using subunit-specific monoclonal antibodies. In addition, the integrin repertoire of three of the transformed cell lines was reexamined after the cells formed tumor nodules in immunodeficient mice. Bronchial epithelial cells in culture expressed multiple integrin subunits with the capability of binding to collagen and laminin (alpha 2, alpha 3, and alpha 6) and at least two subunits that are capable of mediating adhesion to fibronectin (alpha 3 and an alpha v-containing integrin). The alpha v beta 3 vitronectin receptor was not present. This distribution closely mimicked that seen by bronchial epithelial cells in situ. Cell lines derived from transformed pulmonary epithelial cells showed great heterogeneity with respect to integrin expression--some showing fewer, some greater, and some the same types of integrins as nontransformed epithelial cells. Only slight changes in integrin expression were seen in tumor cells propagated in immunodeficient mice. Although the adhesion characteristics of the transformed cells mirrored their adhesion receptor profile, no correlation between integrin profile and the ability to grow in SCID mice was observed. This study defines the integrin repertoire of human bronchial epithelial cells and sets the stage for future investigations exploring how the regulation and signal transduction mechanisms of these receptors might affect important pulmonary processes such as bronchial cell differentiation, wound healing, and malignant transformation.
Low Complex Crypto based Channel Coding with Turbo Code (2013)

A novel encryption system to increase security in a three tier manner without any additional complexity is proposed in this paper. The encryption block here is a Shrinking generator which is a Linear Feedback Shift Register (LFSR) based stream cipher system in which controlled randomness provides security. The channel coding technique used is Turbo code that performs very well and provides results near Shannon's Limit. The design of interleaver used in turbo code provides security while channel coding. Puncturing pattern designed for channel coding further increases the security of the system and improves the code rate also. Security of the system is achieved by hiding the keys used in code generation and puncturing from unintended users. For an intended user, performance of the channel coding system is further improved by using Soft Input Decryption (SID) technique. The hardware complexity of the proposed Shrinking Generator Based Cipher (SGBC) is compared with joint coding cryptographic schemes available in literature. Improved Linear Consistency Attack is mounted to analyze the security of the proposed system and the results show that a significant increase in security could be achieved without any additional increase in complexity.
Actinobacillus pleuropneumoniae-induced thymic lesions in mice and pigs (1991)

Actinobacillus pleuropneumoniae produces several hemolysins/cytotoxins that may be important in the pathogenesis of acute lesions. Little is known, however, about the role of these virulence factors in chronic disease or the carrier state. We investigated the effects of live bacterial infection and transthoracic injection of a sterile culture supernatant on primary lymphoid organs and lymphocyte populations. Transthoracic inoculation of mice or intranasal inoculation of pigs with virulent A. pleuropneumoniae serotypes 1 and 7 induced thymic cortical lymphoid necrosis. These lesions were reproduced in mice by transthoracic injection of a concentrated sterile culture supernatant. The cytotoxic effect of this culture supernatant was also demonstrated in vitro by using a tetrazolium dye reduction assay. Both porcine and murine thymic lymphocytes as well as splenic T lymphocytes were susceptible to the toxin. Porcine convalescent serum, but not preimmune serum, prevented thymic lesions and neutralized the in vitro cytotoxic effect of the culture supernatant on murine thymic lymphocytes. Thymic lesions also were reproduced in mice by using purified lipopolysaccharide (LPS) from Escherichia coli O111:B4; however, LPS had no in vitro cytotoxic effect on either porcine or murine thymic lymphocytes. These results suggest that secreted A. pleuropneumoniae toxin(s) is capable of affecting host T-lymphocyte populations and may affect host immune function.
A Highly Conductive Macrocycle-Linked Metallophthalocyanine Polymer (2000)

Eine aus Makrocyclen aufgebaute Polymerstruktur, bei der die Phthalocyaninringe über Thiophen-Bausteine verbrückt sind (siehe Bild) verfügt über eine um drei Größenordungen höhere Leitfähigkeit als bisher untersuchte makrocyclische Polymere. Starre, dreidimensionale Iptycen-Gerüste verhindern die Aggregation der Makrocyclen und liefern gut lösliche Monomere, bei denen die axialen Positionen der Metallzentren nicht besetzt sind.