gebhart/patrepeval huggingface dataset:
Phosphorylation of the Multidrug Resistance Encoded Protein P190 (1995)

Recent studies suggest that multidrug resistance of HL60/ADR cells is related to an overexpression of the MRP (multidrug resistance associated protein) gene which encodes a 190-kDa ATP-binding membrane glycoprotein. In the present study we have further characterized P190 and have examined phosphorylation properties of the protein. The results demonstrate that P190 is highly phosphorylated and that the phosphate groups are metabolically active and undergo cycles of phosphorylation and dephosphorylation in the cell. Serine is the single amino acid phosphorylated in P190 and the phosphate groups are contained in nine tryptic peptides. Experiments have also been conducted to analyze the effect of various protein kinase inhibitors on phosphorylation levels of P190. The results show that H-7, staurosporine, and chelerythrine can reduce the phosphorylation of this protein. In the presence of both H-7 (200 microM) and staurosporine (200 nM) the phosphorylation of P190 is completely blocked. It has also been found that in the presence of these agents there is a major increase in drug accumulation and concomitant inhibition in drug efflux of resistant cells. These results therefore suggest the possibility that certain phosphate groups of protein P190 play an important role in modulating drug accumulation in resistant cells.
Immunotherapy as a strategy for the treatment of non-small-cell lung cancer (2010)

Positive modulation of a patient's immune system to produce antitumor immunity is an attractive strategy that may improve the dismal outcomes typically associated with non-small-cell lung cancer (NSCLC). Using methods that either augment specific antitumor immunity or positively influence the patient's immune system to allow the de novo generation of immunity to encompass current strategies used in recent clinical trials of NSCLC. Encouraging results of Phase II trials in antigen-specific immunotherapy have led to three subsequent Phase III trials, which are currently enrolling. Results of these trials will improve our understanding of the role that immunotherapy plays in the treatment of NSCLC. Successful application of a humoral vaccine in Cuba led to its approval for the treatment of advanced NSCLC patients in that country. To date, trials involving nonspecific immunotherapeutic interventions have failed to improve outcomes in NSCLC and may indicate a need to combine them with antigen-specific vaccines. Although these trials will greatly advance our knowledge of NSCLC immunotherapy, we believe truly efficacious immunotherapy may only result from implementation of strategies to both augment antitumor immunity and counteract tumor-mediated immunosuppression.
REVIEWS Sophocles and Racine: a comparative study in dramatic technique. By STONEJOHN A.. (Histoire des Idées et Critique Littéraire). Geneva: Droz. 1964. 162 pp. (1965)

REVIEWS Get access Sophocles and Racine: a comparative study in dramatic technique. By JOHN A. STONE. (Histoire des Idées et Critique Littéraire). Geneva: Droz. 1964. 162 pp. R. C. KNIGHT R. C. KNIGHT SWANSEA Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume XIX, Issue 4, October 1965, Pages 413–414, https://doi.org/10.1093/fs/XIX.4.413 Published: 01 October 1965
Interactive Physical Simulation on Multicore Architectures (2009)

In this paper we propose a parallelization of interactive physical simulations. Our approach relies on a task parallelism where the code is instrumented to mark tasks and shared data between tasks, as well as parallel loops even if they have dynamic conditions. Prior to running a simulation step, we extract a task dependency graph that is partitioned to define the task distribution between processors. To limit the overhead of graph partitioning and favor memory locality, we intend to limit the partitioning changes from one iteration to the other. This approach has a low impact on physics algorithms as parallelism is mainly extracted from the coordination code. It makes it non parallel programmer friendly. Results show we can obtain good performance gains.
Build the Offer (2018)

In this chapter, we’ll look at that offer. How do you research what should be in the offer? How do you structure the offer? What are common types of offers? How will you structure billing to reflect an appropriate profit margin? Wait, do you need a contract? We’ll start with researching what should go into an offer.
Idrott mellan folkrörelse och kommersialism (2003)

60 Enligt ordboken ar kommersialisering att gora nagot – i vart fall idrott till foremal for vinstgivande affarsverksamhet. Av detta foljer att kommersiell idrott inte i forsta hand anordnas for idrottens egen skull – for utovare och askadare utan for att ge vinst. For mig ar kommersialisering ett av kannetecknen pa en omfattande omvandlingsprocess som idrotten genomgatt sedan mitten av 1960-talet, och som sammantaget har lett till att idrotten har blivit allt mer integrerad i samhallet. En milstolpe i denna utveckling passerades vid Riksidrottsmotet 1999, da elitidrottsverksamhet i aktiebolagsform mojliggjordes. Nar det galler idrottsforeningar som bolagiserats, liksom privata foretag som gym och fitness centra, ar saken klar: de saljer idrott for att tjana pengar. Men merparten av de cirka 22 000 svenska idrottsforeningar som inte ar bolagiserade, och formodligen inte under overskadlig tid kommer att bli det, erbjuder de ideell idrott utan paverkan fran kommersiella krafter? Nej. Men lat oss borja med att forsoka reda ut hur kommersiell respektive icke-kommersiell idrott kan forstas. I kommersiell form fortingligas idrotten, den blir en vara, producerad Idrott mellan folkrorelse och kommersialism
[Chronic lymphatic leukemia. Peroral cladribine as primary treatment]. (1996)

Ten patients with newly diagnosed B-chronic lymphocytic leukaemia were treated with cladribin orally for five days every four weeks with a median of four series. This is the first reported clinical study where a purine analogue is administered orally. The tumour reducing effect was fast. Eight out of 10 patients responded with a partial or clinical complete remission. Two of these were in molecular biological complete remission. With an observation time of 22 months we have seen no serious side effects so far. A randomized study (including a long term follow up) between chlorambucil, fludarabin and cladribin is needed to clarify the future role of cladribin in B-CLL treatment.
Primary Hyperparathyroidism (1973)

Clinical manifestations, radiographic findings, and bone mineral measurements of 65 patients with primary hyperparathyroidism are reviewed. Fifty per cent presented with renal stones, and 38% had asymptomatic hypercalcemia. Advanced hyperparathyroid skeletal disease was not encountered. On conventional skeletal survey, 10% had minimal subperiosteal bone resorption limited to the phalanges. Radiographically visible osteopenia was uncommon and difficult to assess. By absorptometric analysis and fine-detail radiography, a majority were found to have demineralization and excessive bone resorption. These results illustrate the limitations of conventional radiography and underscore the need for newer more sensitive radiological techniques.
Adaptation layer for the support of multiple physical layer technologies (2004)

4G technologies require higher data rate, wider bandwidth, ultra-connectivity and seamless handover between heterogeneous networks. The adaptation layer enables a mobile terminal to support various physical layer technologies. In this paper, we suggest the functions, primitives, and operational illustrations of the adaptation layer supporting two physical layer technologies, i.e. WCDMA and WLAN.
A Multi-party Contract Signing Protocol and Its Implementation via Trusted Computing (2009)

E-commerce (EC) over open devices and networks poses security challenges of a new dimension. This article presents a multi-party contract signing (MPCS) protocol to demonstrate how to apply the secure EC protocols to trading terminals supported by trusted computing (TC) technology. The protocol here reduces the number of rounds to two and the message transmission number to O(n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ), which is the best known so far. Leveraging the TC technology, an infrastructure of trusted terminal is proposed to guarantee the integrity and trustworthiness of the terminals, with the confidentiality and authenticity of the communication channels ensured by the trusted network connection (TNC) technology.
Inhibition of enterovirus 71‐induced apoptosis by allophycocyanin isolated from a blue‐green alga <i>spirulina platensis</i> (2003)

Enterovirus 71 infection causes significant morbidity and mortality in children, yet there is no effective treatment. In this study, a protein-bound pigment, allophycocyanin purified from blue-green algae is first reported to exhibit anti-enterovirus 71 activity. Allophycocyanin neutralized the enterovirus 71-induced cytopathic effect in both human rhabdomyosarcoma cells and African green monkey kidney cells. The 50% inhibitory concentration of allophycocyanin for neutralizing the enterovirus 71-induced cytopathic effect was approximately 0.045 +/- 0.012 microM in green monkey kidney cells. The cytotoxic concentrations of allophycocyanin for rhabdomyosarcoma cells and African green monkey kidney cells were 1.653 +/- 0.003 microM and 1.521 +/- 0.012 microM, respectively. A plaque reduction assay showed that the concentrations of allophycocyanin for reducing plaque formation by 50% were approximately 0.056 +/- 0.007 microM and 0.101 +/- 0.032 microM, when allophycocyanin were added at the state of viral adsorption and post-adsorption, respectively. Antiviral activity was more efficient in cultures treated with allophycocyanin before viral infection compared with that in the cultures treated after infection. Allophycocyanin was also able to delay viral RNA synthesis in the infected cells and to abate the apoptotic process in enterovirus 71-infected rhabdomyosarcoma cells with evidence of characteristic DNA fragmentation, decreasing membrane damage and declining cell sub-G1 phase. It is concluded that allophycocyanin possesses antiviral activity and has a potential for development as an anti-enterovirus 71 agent.
The direct cost of virtual function calls in C++ (1996)

We study the direct cost of virtual function calls in C++ programs, assuming the standard implementation using virtual function tables. We measure this overhead experimentally for a number of large benchmark programs, using a combination of executable inspection and processor simulation. Our results show that the C++ programs measured spend a median of 5.2% of their time and 3.7% of their instructions in dispatch code. For "all virtuals" versions of the programs, the median overhead rises to 13.7% (13% of the instructions). The "thunk" variant of the virtual function table implementation reduces the overhead by a median of 21% relative to the standard implementation. On future processors, these overheads are likely to increase moderately.
Synthesis of perhydropyrazino[1,2‐<i>d</i>][1,4]diazepine, a new heterocyclic compound (1993)

Abstract A novel heterocycle, perhydropyrazino[1,2‐ d ][1,4]diazepine, is prepared in good yield by an efficient method starting from facile available compounds.
Impact & Blast Traumatic Brain Injury: Implications for Therapy (2018)

Traumatic brain injury (TBI) is one of the most frequent causes of combat casualties in Operations Iraqi Freedom (OIF), Enduring Freedom (OEF), and New Dawn (OND). Although less common than combat-related blast exposure, there have been significant numbers of blast injuries in civilian populations in the United States. Current United States Department of Defense (DoD) ICD-9 derived diagnoses of TBI in the DoD Health Care System show that, for 2016, severe and moderate TBIs accounted for just 0.7% and 12.9%, respectively, of the total of 13,634 brain injuries, while mild TBIs (mTBIs) accounted for 86% of the total. Although there is a report that there are differences in the frequency of long-term complications in mTBI between blast and non-blast TBIs, clinical presentation is classified by severity score rather than mechanism because severity scoring is associated with prognosis in clinical practice. Blast TBI (bTBI) is unique in its pathology and mechanism, but there is no treatment specific for bTBIs-these patients are treated similarly to TBIs in general and therapy is tailored on an individual basis. Currently there is no neuroprotective drug recommended by the clinical guidelines based on evidence.
Enhanced gene repair mediated by methyl-CpG-modified single-stranded oligonucleotides (2009)

Gene editing mediated by oligonucleotides has been shown to induce stable single base alterations in genomic DNA in both prokaryotic and eukaryotic organisms. However, the low frequencies of gene repair have limited its applicability for both basic manipulation of genomic sequences and for the development of therapeutic approaches for genetic disorders. Here, we show that single-stranded oligodeoxynucleotides (ssODNs) containing a methyl-CpG modification and capable of binding to the methyl-CpG binding domain protein 4 (MBD4) are able to induce >10-fold higher levels of gene correction than ssODNs lacking the specific modification. Correction was stably inherited through cell division and was confirmed at the protein, transcript and genomic levels. Downregulation of MBD4 expression using RNAi prevented the enhancement of gene correction efficacy obtained using the methyl-CpG-modified ssODN, demonstrating the specificity of the repair mechanism being recruited. Our data demonstrate that efficient manipulation of genomic targets can be achieved and controlled by the type of ssODN used and by modulation of the repair mechanism involved in the correction process. This new generation of ssODNs represents an important technological advance that is likely to have an impact on multiple applications, especially for gene therapy where permanent correction of the genetic defect has clear advantages over viral and other nonviral approaches currently being tested.
Spectrophotometric and Potentiometric Evaluation of Apparent Acid Dissociation Exponents of Various 4-Aminoquinoline˙s<sup>1</sup> (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectrophotometric and Potentiometric Evaluation of Apparent Acid Dissociation Exponents of Various 4-Aminoquinoline˙s1J. Logan Irvin and Elinor Moore IrvinCite this: J. Am. Chem. Soc. 1947, 69, 5, 1091–1099Publication Date (Print):May 1, 1947Publication History Published online1 May 2002Published inissue 1 May 1947https://pubs.acs.org/doi/10.1021/ja01197a034https://doi.org/10.1021/ja01197a034research-articleACS PublicationsRequest reuse permissionsArticle Views161Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The predictability of load address (2001)

Memory access latency is the traditional bottleneck of system performance. Cache is historically introduced to bridge the big gap between processor and main memory so as to reduce the load-to-use delay. The traditional one cycle cache latency has already caused problems for pipeline execution. The situation becomes worse for modern deep pipelined superscalar processor when clock rate continues to increase and cache capacity increases, which inevitably lead to more cycle cache latency.Load address prediction could alleviate the load-to-use delay by predicting the target address of load instruction in the early stage of pipeline. But existing address prediction schemes can only predict up to 67% regular address pattern.To explore the potential of address prediction, in this paper, from the program behavior, we study and simulate various load address change patterns. Our results first show that the address of load has high repeatability. We further classify load instructions naturally into several categories and analyze their behavior respectively. The reason for both correct address prediction and incorrect prediction are studied from program behavior. The load instructions with low prediction rate are further analyzed. Focused on the high misprediction for load from stack scalar variable, one new prediction schemes: stack coloring is proposed. Furthermore, we also propose a new context predictor: global context predictor, which greatly saves the prediction resources. Our results show that the high predictability with 77.5%, 75.8% and 90.6% can be achieved for stride, context and hybrid predictor respectively.
Ku acts in a unique way at the mammalian telomere to prevent end joining (2000)

Telomeres are specialized DNA/protein structures that act as protective caps to prevent end fusion events and to distinguish the chromosome ends from double-strand breaks. We report that TRF1 and Ku form a complex at the telomere. The Ku and TRF1 complex is a specific high-affinity interaction, as demonstrated by several in vitro methods, and exists in human cells as determined by coimmunoprecipitation experiments. Ku does not bind telomeric DNA directly but localizes to telomeric repeats via its interaction with TRF1. Primary mouse embryonic fibroblasts that are deficient for Ku80 accumulated a large percentage of telomere fusions, establishing that Ku plays a critical role in telomere capping in mammalian cells. We propose that Ku localizes to internal regions of the telomere via a high-affinity interaction with TRF1. Therefore, Ku acts in a unique way at the telomere to prevent end joining.
DNA CpG methylation inhibits binding of NF-kappa B proteins to the HIV-1 long terminal repeat cognate DNA motifs. (1991)

The regulation of cellular or viral gene expression is directly influenced by the pattern of methylated cytosine residues localized in the DNA of enhancer/promoter sequences. The mechanism of transcriptional silencing has been explained on the basis of either an indirect model, in which densely methylated DNA is recognized by proteins that may displace crucial transcription factors, or a direct model, in which binding of a single transcription protein is prevented by the presence of a methylated CpG dinucleotide localized in a sensitive region of a DNA motif. In this study, we have determined that methylation of the core CpG dinucleotide located within the NF-kappa B repeated motifs of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat can inhibit the binding of the NF-kappa B protein complex from crude nuclear extracts or from purified bovine spleen and specifically inhibit the binding of recombinant p50 protein. We have used the electrophoretic mobility shift assay (EMSA) and DNaseI footprinting analysis to demonstrate that binding of the NF-kappa B proteins to their cognate motifs can be inhibited via the direct model proposed for methylation-mediated inhibition of DNA-protein interaction.
EBG enhanced dielectric lens antennas for the imaging at sub-mm waves (2008)

This paper presents a truly integrated antennas in mm and sub-mm wave regimes can be realized by printing planar radiating elements in the focal plane of elliptical or extended hemispherical lens antennas. The elliptical shape of the lens gives high focusing properties provided that its eccentricity is properly related to its dielectric constant (e=1/epsiv <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sup> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> ). In the frame of cooperation activity between TNO and SRON, the main purpose of this contribution is to present a new way to increase the directivity of the focal plane feeds typically used to excite such lenses. The driving reason for this effort is the desire to diminish the impact of the reflections at the dielectric air interface when these structures are proposed as focal plane imagers.
Inverse SAR approach for localization of moving RFID tags (2013)

This paper presents an inverse synthetic aperture radar approach for localizing standard UHF RFID transponders. The proposed method is a powerful option to estimate the positions of tags that pass RFID gates or read points. A priori information about the relative transponder trajectory, such as the speed of a conveyor belt or a trajectory created by a robotic arm or rotary table, is used to generate an inverse synthetic aperture. Sampled phase data from RFID signals which are backscattered to single or multiple antennas combined with the information on the relative RFID tag trajectory are used to reconstruct the tag's absolute trajectory. The paper describes basic properties of synthetic apertures in RFID systems and methods of evaluating beam patterns based on array beam steering theory. Simulations of a conveyor belt scenario and test data acquired from an industrial rotary table transporting tagged objects are described. The experimental results prove that our novel method enables robust localization of moving RFID tags even in a severe multipath environment.
Harmonic distortion in switched-current audio memory cells (1999)

Harmonic distortion in switched-current memory cells is investigated, and closed-form equations are presented concerning the effects of threshold voltage mismatch, signal dependent output conductance, and clock injection. We show that output conductance can be the main source of distortion in basic cells, but clock injection is dominant in regulated cascode (RgC), grounded-gate regulated cascode, and Shah-Toumazou cells. Concerning the V-I converter, we show that if this is simply a resistor at the input of either a GGRgC or an RgC Shah-Toumazou cell, the resulting distortion is very low. Our results have been confirmed by SPICE simulations and by measurements made on two 1.2 /spl mu/m CMOS prototype chips.
Nanostructured Sexithiophene/Clay Hybrid Mutilayers:  A Comparative Structural and Morphological Characterization (2002)

Ultrathin films prepared from inorganic and organic materials are of increasing interest as hybrid nanocomposite materials. We have investigated for the first time the formation of nanostructured ultrathin films of montmorillonite clay (MONT) and a bicationic sexithiophene derivative (6TN) using the layer-by-layer self-assembly approach. The main goal is to investigate the structure and layer ordering of these films suitable for future applications in organic semiconductor devices. We have compared the structure and morphology of 6TN/MONT multilayer thin films prepared from pure water and 0.1 M NaCl systems. The 6TN amphiphile showed unique aggregation behavior both in solution and on the surface, which changes with the presence of salts and a THF cosolvent. On clay surfaces, the 6TN aggregates deposited from saline solutions have a more uniform size distribution and surface coverage than that from a pure water system. This was verified by UV−vis spectra, X-ray diffraction (XRD), and atomic force microscopy (AFM). The idea of incorporating more 6TN species absorbed on the surface while yielding a smoother surface morphology have a great significance in semiconductor device fabrication.