gebhart/patrepeval huggingface dataset:
KIR Ligands and Prediction of Relapse after Unrelated Donor Hematopoietic Cell Transplantation for Hematologic Malignancy (2006)

Recurrent malignancy remains a significant complication after allogeneic hematopoietic cell transplantation (HCT). Efforts to decrease relapse have included donor lymphocyte infusion to stimulate donor anti-recipient T-cell allorecognition of major and minor histocompatibility differences. Recently, alloreactive effects of donor natural killer cell-mediated inhibitory killer immunoglobulin-like receptor (KIR) recognition of recipient HLA-C and -B ligands have been described. We examined KIR ligand effects on risk of relapse in 1770 patients undergoing myeloablative T-replete HCT from HLA-matched or -mismatched unrelated donors for the treatment of myeloid and lymphoid leukemias. KIR ligands defined by HLA-B and -C genotypes were used to determine donor-recipient ligand incompatibility or recipient lack of KIR ligand. Among HLA-mismatched transplantations, recipient homozygosity for HLA-B or -C KIR epitopes predicted lack of KIR ligand and was associated with a decreased hazard of relapse (hazard ratio, 0.61; 95% confidence interval, .043-0.85; P = .004). Absence of HLA-C group 2 or HLA-Bw4 KIR ligands was associated with lower hazards of relapse (hazard ratio, 0.47; 95% confidence interval, 0.28-0.79, P = .004; hazard ratio, 0.56; 95% confidence interval, 0.33-0.97; P = .04, respectively). The decrease in hazard of relapse in patients with acute myelogenous leukemia was similar to that in patients with chronic myelogenous leukemia and acute lymphoblastic leukemia (P = .95). Recipient homozygosity for HLA-B or -C epitopes that define KIR ligands is likely to be a predictive factor for leukemia relapse after myeloablative HCT from HLA-mismatched unrelated donors. This effect was not observed in HLA-identical unrelated transplants.
Real-time indoor scene understanding using Bayesian filtering with motion cues (2011)

We present a method whereby an embodied agent using visual perception can efficiently create a model of a local indoor environment from its experience of moving within it. Our method uses motion cues to compute likelihoods of indoor structure hypotheses, based on simple, generic geometric knowledge about points, lines, planes, and motion. We present a single-image analysis, not to attempt to identify a single accurate model, but to propose a set of plausible hypotheses about the structure of the environment from an initial frame. We then use data from subsequent frames to update a Bayesian posterior probability distribution over the set of hypotheses. The likelihood function is efficiently computable by comparing the predicted location of point features on the environment model to their actual tracked locations in the image stream. Our method runs in real-time, and it avoids the need of extensive prior training and the Manhattan-world assumption, which makes it more practical and efficient for an intelligent robot to understand its surroundings compared to most previous scene understanding methods. Experimental results on a collection of indoor videos suggest that our method is capable of an unprecedented combination of accuracy and efficiency.
Assessment of the cytocompatibility of different coated titanium surfaces to fibroblasts and osteoblasts (2005)

Over the years, many metal and polymer implants have been developed for internal fracture fixation. However, there are always some problems associated with their application, such as implant loosening or infection. This study describes how the morphology and adhesion of both fibroblasts and osteoblasts to two manufactured commercially pure, medical implant-quality anodized titanium surfaces (TS and TSS), and five modified titanium surfaces (TLF, low friction gray anodized titanium; TIG, nitrogen ion implanted TSS; THY, TSS grafted with sodium hyaluronate; TAST, TSS coated with hydrophilic hydrogel; and TT, tiodized TS) were used to obtain an indication of their relative cytocompatibility and to assess which modified surface could potentially be used in vivo. Small variations were observed both qualitatively and quantitatively in the spreading and adhesion of fibroblasts and osteoblasts to the studied surfaces. Overall, fibroblast spreading and adhesion were greatest on the TIG and TLF surfaces. Osteoblast spreading and adhesion were greatest on TS, TIG, and TAST surfaces. No fibroblasts or osteoblasts were found attached to the THY-coated surfaces. Coating medical implant-quality anodized titanium surfaces (TS and TSS) with a TLF, TAST, or more specifically TIG could probably improve soft tissue adhesion and/or osseointegration of bone in vivo. However, it seemed that a hyaluronic acid coating (THY) has potential as a coating in areas where cell adhesion is undesirable, such as orbital fractures, where muscles should avoid adhesion to the implant, and distal radius fractures, where tendons should freely glide over the implant.
Restoring Euglycemia in the Basal State Using Continuous Glucose Monitoring in Subjects with Type 1 Diabetes Mellitus (2007)

Background: Our objective was to use continuous glucose monitoring to derive the optimal basal insulin infusion rates in adults with type 1 diabetes and using continuous subcutaneous insulin infusion (CSII) pumps. Methods: In an effort to mimic euglycemia during the basal state, we used a standard protocol to adjust basal insulin infusion rates in 16 subjects with type 1 diabetes mellitus who were using CSII pumps. All subjects wore Continuous Glucose Monitoring System sensors (CGMS®, Medtronic Minimed, Northridge, CA) in order to obtain around-the-clock tracings of their glucose measurements. Subjects were asked to skip meals periodically in order to optimize basal insulin infusion rates, defined as the basal infusion rates that maintained glucose levels in the range of 65–120 mg/dL during the fasting state or between meals. Results: In order to demonstrate improved glycemic control, with blunting of glucose excursion, we compared the baseline CGMS area under the curve (AUC) to the AUC obtained after optimizing the basal insulin dosages. We analyzed the curves by determining the AUC for glucose excursions above 110 mg/dL. The AUC for glucose excursions above 110 mg/dL was significantly smaller after optimization (19 ± 13 mg/dL·day) compared to the baseline AUC (50 ± 31 mg/dL·day) (P < 0.001). Conclusions: Using both a standard protocol for initial basal insulin infusion rates and CGMS curves to optimize basal infusion rates, one can improve glycemia in subjects with type 1 diabetes using CSII.
Restricted isometry properties and nonconvex compressive sensing (2008)

The recently emerged field known as compressive sensing has produced powerful results showing the ability to recover sparse signals from surprisingly few linear measurements, using ℓ1 minimization. In previous work, numerical experiments showed that ℓp minimization with 0 < p < 1 recovers sparse signals from fewer linear measurements than does ℓ1 minimization. It was also shown that a weaker restricted isometry property is sufficient to guarantee perfect recovery in the ℓp case. In this work, we generalize this result to an ℓp variant of the restricted isometry property, and then determine how many random, Gaussian measurements are sufficient for the condition to hold with high probability. The resulting sufficient condition is met by fewer measurements for smaller p. This adds to the theoretical justification for the methods already being applied to replacing high-dose CT scans with a small number of x-rays and reducing MRI scanning time. The potential benefits extend to any application of compressive sensing.
A fast algorithm for the disjunctive decomposition of m-valued functions. I. The decomposition algorithm (2002)

The binary function decomposition algorithm of V. Shen et al. (1971) is generalized to m-valued functions with m>2. The necessary condition for the decomposability for m-valued functions is obtained and used in generating candidate bound sets. A fast method for testing the necessary condition using partial partition tables whereby the decomposability of the function can be determined for a randomly chosen function in (nm)/sup 3/ time is also obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The damage that has become 2010 : intellectual property (2010)

By the time you read this, the 2010 FIFA World Cup (or whatever its official name really is) will probably be under way, in fact it may even be over. And you may be thinking this : what on earth happened in South Africa during the years and months leading up to the event? Did some sort of collective madness take over? If so, will sanity ever return?
Flagellin gene transcription in Bordetella bronchiseptica is regulated by the BvgAS virulence control system (1993)

The products of the bvgAS locus activate expression of a majority of the known Bordetella virulence factors but also exert negative control over a class of genes called vrg genes (bvg-repressed genes). BvgAS negatively controls the production of flagella and the phenotype of motility in Bordetella bronchiseptica. In this study flaA, the flagellin gene, was cloned and characterized to facilitate studies of this negative control pathway. An internal flaA probe detected hybridizing sequences on genomic Southern blots of Bordetella pertussis, Bordetella parapertussis, and Bordetella avium, although B. pertussis and B. parapertussis are nonmotile. FlaA is similar to the FliC flagellins of Salmonella typhimurium and Escherichia coli, and flaA complemented an E. coli flagellin mutant. Insertional inactivation of the chromosomal flaA locus eliminated motility, which was restored by complementation with the wild-type locus. Analysis of flaA mRNA production by Northern (RNA) blotting and primer extension indicated that negative regulation by BvgAS occurs at the level of transcription. The transcriptional start site of flaA mapped near a consensus site for the alternative sigma factor, sigma F, encoded by fliA in E. coli and S. typhimurium. Consistent with a role for a fliA analog in B. bronchiseptica, transcriptional activation of a flaA-lacZ fusion in E. coli required fliA and a flaA-linked locus designated frl.frl also efficiently complemented mutations in the flagellar master regulatory locus, flhDC, of E. coli. Our analysis of the motility phenotype of B. bronchiseptica suggests that the Bordetella virulence control system mediates transcriptional control of flaA through a regulatory hierarchy that includes the frl locus and an alternative sigma factor.
Nuclear Molecular Imaging Strategies in Immune Checkpoint Inhibitor Therapy (2017)

Immune checkpoint inhibitor therapy (ICT) is a new treatment strategy developed for the treatment of cancer. ICT inhibits pathways known to downregulate the innate immune response to cancer cells. These drugs have been shown to be effective in the treatment of a variety of cancers, including metastatic melanoma and lung cancer. Challenges in response evaluation of patients in ICT have risen as immune related side effects and immune cell infiltration may be confused with progressive disease. Furthermore, the timing of the evaluation scan may be challenged by relatively slow responses. To overcome this, new response criteria for evaluating these patients with morphologic imaging have been proposed. The aim of this paper is to review and discuss the current evidence for the use of molecular imaging, e.g., PET/CT (Positron Emission Tomography/Computer Tomography) with <sup>18</sup>F-Fluorodeoxyglucoes (FDG) as an alternative imaging method for monitoring patients undergoing ICT. Following the currently available evidence, this review will primarily focus on patients with malignant melanoma.
Using common subexpressions to optimize multiple queries (2003)

The problem of identifying common subexpressions and using them in the simultaneous optimization of multiple queries is dealt with. In particular, emphasis is placed on the strategy of selecting access plans for single queries and their integration into a global access plan that takes advantage of common tasks. A dynamic programming algorithm is presented for the selection of individual access plans such that the resulting global access plan is of minimum processing cost. The computational complexity of this algorithm represents a significant improvement over existing algorithms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Red propolis: Chemical composition and pharmacological activity (2017)

Propolis has been used worldwide for years in folk medicine and currently marketed by the pharmaceutical industry. In Brazil, propolis was classified into 13 groups based on their organoleptics and physicochemical characteristics. The 13th type named red propolis has been an important source of investigation since late 90s. Their property comes from the countless compounds, including terpenes, pterocarpans, prenylated benzophenones and especially the flavonoids. This last compound class has been indicated as the responsible for its potent pharmacological actions, highlighting the antimicrobial, anti-inflammatory, antioxidant, healing and antiproliferative activities. The red propolis can also be found in other countries, especially Cuba, which has similar features as the Brazilian. Therefore, with the compilation of 80 papers, this review aims to provide a key reference for researchers interested in natural products and discovery of new active compounds, such as from propolis.
The structure of tannins of some edible fruits (1981)

Abstract The tannins of 20 species of edible fruits are described. The majority contain condensed tannins (polymeric proanthocyanidins) whose structural units and number average molecular weight have been determined. Some fruits contain both condensed and hydrolysable, or hydrolysable tannins alone—notably those in the genus Rubus . The structures of tannins in the fruit and leaves are compared in several cases.
Biodistribution of Pristine Single-Walled Carbon Nanotubes In Vivo (2007)

The biodistribution of pristine single-walled carbon nanotubes (SWNTs) in mice was determined by using the skeleton 13C-enriched SWNTs and isotope ratio mass spectroscopy. The results suggested that the SWNTs were distributed in the entire body, with major accumulations in the liver, lungs, and spleen over an extended period of time. The specimen from the effected organ tissues were examined by using transmission electron microscopy, aimed toward an understanding of the possible uptake mechanism. The biological consequence of pristine SWNTs is obviously very different from that of their chemically modified or functionalized counterparts. The implication of such a fact is discussed.
Preparation and characterization by thermal analysis of magnetic latex particles (1993)

Abstract Emulsion polymerization of styrene and methyl methacrylate in the presence of a ferrofluid was briefly studied. Thermal properties of the resulted latex particles were investigated by TG–DTA analysis. Determination of the residue weight after the thermal analysis that indicated complete decomposition of the organic components was found to be a facile and practical method to determine the magnetite content in the latex particles. The method was applied to magnetic polystyrene latex particles prepared in the presence of various amounts of the ferrofluid. Analysis of the results suggested that the magnetic content in the latex particles is primarily determined by the weight ratio of the ferrofluid to monomer. © 1993 John Wiley & Sons, Inc.
A practical access to methyl 3,3-dimethoxypropionates and N-protected .beta.-aminoacrylates and .beta.-aminoacrylonitrile by using electrochemical procedure (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA practical access to methyl 3,3-dimethoxypropionates and N-protected .beta.-aminoacrylates and .beta.-aminoacrylonitrile by using electrochemical procedureSigeru Torii, Tsutomu Inokuchi, and Minoru KubotaCite this: J. Org. Chem. 1985, 50, 21, 4157–4160Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/jo00221a038https://doi.org/10.1021/jo00221a038research-articleACS PublicationsRequest reuse permissionsArticle Views496Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Time from Infection with Human Immunodeficiency Virus (HIV) to the Onset of AIDS (1986)

Journal Article The Time from Infection with Human Immunodeficiency Virus (HIV) to the Onset of AIDS Get access Jeremy M. G. Taylor, Jeremy M. G. Taylor Divisions of Biostatistics and Epidemiology, School of Public Health, UCLA, Los Angeles, California Please address requests for reprints to Dr. Jeremy M. G. Taylor, Division of Biostatistics, School of Public Health, UCLA, Los Angeles, California 90024. Search for other works by this author on: Oxford Academic PubMed Google Scholar Kendra Schwartz, Kendra Schwartz Divisions of Biostatistics and Epidemiology, School of Public Health, UCLA, Los Angeles, California Search for other works by this author on: Oxford Academic PubMed Google Scholar Roger Detels Roger Detels Divisions of Biostatistics and Epidemiology, School of Public Health, UCLA, Los Angeles, California Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 154, Issue 4, October 1986, Pages 694–697, https://doi.org/10.1093/infdis/154.4.694 Published: 01 October 1986 Article history Received: 24 January 1986 Revision received: 12 May 1986 Published: 01 October 1986
An Evaluation of Photoengraved Microelectrodes for Extracellular Single-Unit Recording (1973)

Microelectrodes fabricated using integrated-circuit technology are shown to be suitable for extracellular single-unit recording, and the factors influencing electrode-cell coupling are discussed. Electrode tip size as well as location is found to be critical in recording high spike amplitudes, suggesting that the paths for current flow in central nervous system (CNS) tissue may be extremely small.
M protein of a<i>Streptococcus dysgalactiae</i>human wound isolate shows multiple binding to different plasma proteins and shares epitopes with keratin and human cartilage (1999)

Besides group A (GAS), Lancefield group C beta-haemolytic streptococci (GCS) have been implicated as a causative agent in outbreaks of purulent pharyngitis. In this study we have investigated a class CI M protein of a Streptococcus dysgalactiae1:256, revealed that 26% of these sera showed serological cross-reactivity between a 68-kDa cartilage protein and the N-terminal part of MC. Only 8% of the sera of healthy patients showed this property. In additional, MC also cross-reacted with antibodies recognising epidermal keratins. The cross-reacting 68-kDa protein from cartilage was different from human serum albumin, but was recognised with anti-vimentin immune serum. The MC was cloned and the gene sequenced. By using PCR, recombinant gene fragments encoding characteristic peptide fragments of MC were expressed in Escherichia coli. The peptides were used to map the binding sites for plasma proteins and to locate the cross-reacting epitopes on the MC molecule. In consequence, sequence alignments revealed that MC shared homologous regions with vimentin and different keratins. Our data, obtained with MC, suggest that not only infections with GAS but also infections with GCS and possibly GGS (the latter species can also produce class CI M-like proteins) may be responsible for the formation of streptococcal-associated sequel diseases.
Reliability analysis in self-repairing embryonic systems (2003)

One characteristic of biological organisms that is desirable in engineering systems is the ability to tolerate faults in their components. Fault tolerance in artificial cellular systems is generally achieved by either time-redundancy or hardware-redundancy. In hardware redundancy spare cells are introduced so that when an active cell fails, a spare substitutes it in the embryonic hardware architecture designed at York, this hardware redundancy is achieved in a multi-cellular system inspired by cell embryology. In this paper the k-out-of-m reliability model is used to analyse the reconfiguration strategies used in embryonic arrays. Two schemes are investigated: row (or column) elimination and cell-elimination. The models proposed can be used to analyse the reliability of cellular systems with spares other than embryonic arrays.
Subpicosecond Magnetization Reversal across Ferrimagnetic Compensation Points (2007)

Subpicosecond magnetization reversal is experimentally demonstrated by ultrafast heating of a ferrimagnet across its compensation points, under an applied magnetic field. While the reversal is initiated by crossing the magnetization compensation temperature, the short reversal time is related to the angular momentum compensation, where the dynamics of the system is highly accelerated owing to the divergence of the gyromagnetic ratio. These results demonstrate the feasibility of subpicosecond magnetization reversal previously believed impossible.
Linnaeus was right all along:<i>Ulva</i>and<i>Enteromorpha</i>are not distinct genera (2003)

Ulva, one of the first Linnaean genera, was later circumscribed to consist of green seaweeds with distromatic blades, and Enteromorpha Link was established for tubular forms.Although several lines of evidence suggest that these generic constructs are artificial, Ulva and Enteromorpha have been maintained as separate genera.Our aims were to determine phylogenetic relationships among taxa currently attributed to Ulva, Enteromorpl/(J, Umhraulva Bae et I.K. Lee and the monotypic genus Chloropelta C.E. Tanner.and to make any nomenclatural changes justified by our findings.Analyses of nuclear ribosomal internal transcribed spacer DNA (ITS nrDNA) (29 ingroup taxa including the type species of Ulm and Ellteromorpha), the chloroplast-encoded rbcL gene (for a subset of taxa) and a combined data set were carried out.All trees had a strongly supported clade consisting of all Ulva.Enteromorpha and Chloropelta species.but Ulva and Enteromorphu were not monophyletic.The recent removal of Umbraulva olivascens (PJ.L. Dangeard) Bae et I.K. Lee from Ulm is supported, although the relationship of the segregate genus Umhraulva to Uharia requires further investIgation.These results, combined with earlier molecular and culture data, provide strong evidence that Ulva, EllteromorpJIlI and Chloropelta are not distinct evolutionary entities and should not be recognized as separate genera.A comparison of traits for surveyed species revealed few synapomorphies.Because Ulva is the oldest name, Enteromorpha and Ch/oropefta are here reduced to synonymy with Ulva, and new combinations are made where necessary.