gebhart/patrepeval huggingface dataset:
Self-configuration and self-optimization in LTE-advanced heterogeneous networks (2013)

Self-organizing network, or SON, technology, which is able to minimize human intervention in networking processes, was proposed to reduce the operational costs for service providers in future wireless systems. As a cost-effective means to significantly enhance capacity, heterogeneous deployment has been defined in the 3GPP LTEAdvanced standard, where performance gains can be achieved through increasing node density with low-power nodes, such as pico, femto, and relay nodes. The SON has great potential for application in future LTE-Advanced heterogeneous networks, also called HetNets. In this article, state-of-the-art research on self-configuring and self-optimizing HetNets are surveyed, and their corresponding SON architectures are introduced. In particular, we discuss the issues of automatic physical cell identifier assignment and radio resource configuration in HetNets based on selfconfiguring SONs. As for self-optimizing SONs, we address the issues of optimization strategies and algorithms for mobility management and energy saving in HetNets. At the end of the article, we show a testbed designed for evaluating SON technology, with which the performance gain of SON algorithms is demonstrated.
Selenium and amino acid composition of selenoprotein P, the major selenoprotein in rat serum. (1990)

Selenoprotein P is the second plasma selenoprotein to be purified. It is a glycoprotein and has been shown to be distinct from plasma glutathione peroxidase. This study characterizes selenoprotein P further. Deglycosylation of the protein shifts its migration on sodium dodecyl sulfate-polyacrylamide gel electrophoresis from Mr 57,000 to Mr 43,000, indicating it has a substantial carbohydrate component. Measurement of selenium indicates a selenium content of 7.5 +/- 1.0 atoms/molecule based on a polypeptide weight of 43,000. Amino acid analysis accounts for all the selenium as selenocysteine. The protein is also rich in cysteine (17 residues) and histidine (23 residues). Fragmentation of selenoprotein P by trypsin and by cyanogen bromide produces peptides with varying selenium content. This indicates that selenium-rich regions of the protein exist. The concentration of selenoprotein P determined by radioimmunoassay in serum from control rats is 26.3 +/- 4.5 micrograms/ml and in serum from selenium-deficient rats it is 2.7 +/- 0.8 micrograms/ml. Depletion of selenoprotein P from control serum using an immunoaffinity column indicates that over 60% of serum selenium in the rat is contained in this protein. These results demonstrate that selenoprotein P is the major form of selenium in rat serum. It is the first selenoprotein described which has more than one selenium atom/polypeptide chain.
The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat (1993)

Tamoxifen (TAM) is used in the treatment of breast cancer and is being given to healthy women to inhibit breast cancer. The present study examines the effects of TAM in female rats exposed for up to one year. Starting at 6 weeks of age, groups of 55-57 female Sprague-Dawley rats were given TAM by gavage daily at 2.8, 11.3 or 45.2 mg/kd body weight/day, for up to 1 year with two recovery segments, 4 weeks of recovery after 6 months of exposure, and 3 months of recovery after 12 months of exposure. Complete necropsies and histopathology were performed. Drug-related mortality was highest in the high TAM group. In the two high dose groups, hepatoproliferative lesions were present in time- and dose-related incidence, severity and multiplicity. In the high dose rats, at 6 months, hepatocellular adenomas and carcinomas were observed in 71 and 29% of rats respectively. With 1 month of recovery, at 7 months the adenomas and carcinomas were increased to 75%. At 12 months the adenomas were present in 50% and carcinomas in 75% of high dose rats. In the mid dose group, liver lesions were not found until 12 months; at this time 50% had adenomas and 10%, carcinomas. After a 3 month recovery period, 45% exhibited adenomas and 45%, carcinomas. Thus, TAM at 45.2 mg/kg/day elicited hepatocellular neoplasia sometime between 3 and 6 months of administration. At 11.3 mg/kg the neoplastic process was evident at 12 months. At 2.8 mg/kg, no hepatoproliferative changes were found. The strong hepatocarcinogenic effect of TAM in rats raises issues bearing on the prophylactic chronic administration to healthy women.
The Proximal Convoluted Tubule is a Target for the Uroguanylin‐regulated Natriuretic Response (2006)

Together, these findings further establish a role for uroguanylin in fluid homeostasis and support a role for uroguanylin as an integral component of a signaling mechanism that mediates changes in Na excretion in response to an enteral salt loading. Proximal tubular NHE3 activity is a possible target for uroguanylin-mediated changes in Na excretion.
A Byzantine Fault Tolerant Distributed Commit Protocol (2007)

In this paper, we present a Byzantine fault tolerant distributed commit protocol for transactions running over un- trusted networks. The traditional two-phase commit protocol is enhanced by replicating the coordinator and by running a Byzantine agreement algorithm among the coordinator replicas. Our protocol can tolerate Byzantine faults at the coordinator replicas and a subset of malicious faults at the participants. A decision certificate, which includes a set of registration records and a set of votes from participants, is used to facilitate the coordinator replicas to reach a Byzantine agreement on the outcome of each transaction. The certificate also limits the ways a faulty replica can use towards non-atomic termination of transactions, or semantically incorrect transaction outcomes.
Secondary Structure is the Major Determinant for Interaction of HIV <i>rev</i> Protein with RNA (1990)

A region in the human immunodeficiency virus (HIV) env message, with the potential to form a complex secondary structure (designated RRE), interacts with the rev protein (Rev). This interaction is believed to mediate export of HIV structural messenger RNAs from the nucleus to the cytoplasm. In this report the regions essential for Rev interaction with the RRE are further characterized and the functional significance of Rev-RRE interaction in vivo is examined. A single hairpin loop structure within the RRE was found to be a primary determinant for Rev binding in vitro and Rev response in vivo. Maintenance of secondary structure, rather than primary nucleotide sequence alone, appeared to be necessary for Rev-RNA interaction, which distinguishes it from the mechanism for cis-acting elements in DNA. Limited changes within the 200 nucleotides, which preserved the proper RRE conformational structure, were well tolerated for Rev binding and function. Thus, variation among the RRE elements present in the diverse HIV isolates would have little, if any, effect on Rev responsiveness.
Organization and regulation of genes for amino acid biosynthesis in lactic acid bacteria (1993)

The recent description of large clusters of biosynthetic genes in the chromosome of Lactococcus lactis and, to a lesser extent, of Lactobacillus, has brought some information on gene organization and control of gene expression in these organisms. The genes involved in a given amino acid biosynthetic pathway are clustered at a single chromosomal location and form an operon. Additional genes which are not required for the biosynthesis are present within some operons. Genetic signals are, in general, similar to those found in other prokaryotes. Several systems controlling gene expression have been identified and transcription attenuation seems frequent. Among the attenuation mechanisms identified, one resembles that controlling amino acid biosynthesis in many bacteria by ribosome stalling at codons corresponding to limiting amino acid. The others are different and might be related to a new class of attenuation mechanism. Preliminary evidence for a new type of regulatory mechanism, involving a metabolic shunt, is also reviewed.
Investigating the use of an on-chip sensor to monitor NBTI effect in SRAM (2012)

Today, the increasing need to store more and more information has resulted in the fact that Static Random Access Memories (SRAMs) occupy the greatest part of a System-on-Chip (SoC). Therefore, SRAM's robustness is considered crucial to guarantee the reliability of such SoCs over lifetime. In this context, one of the most important phenomena degrading nano-scale SRAMs reliability is related to Negative-Bias Temperature Instability (NBTI). This paper proposes a new approach based on an On-Chip Aging Sensor (OCAS) to detect SRAM aging during system lifetime. The sensor is able to detect any specific aging state of a cell in the SRAM array. The strategy is based on the connection of an OCAS per SRAM column, which periodically performs off-line testing by monitoring write operations into the SRAM cells to detect aging. The approach is application-transparent since it is does not change the SRAM contents after testing. To prevent OCAS from aging by one side and from dissipating static power by the other side, OCAS circuitry is powered-off during idle periods. SPICE simulations in a 65nm CMOS technology demonstrate the high sensor sensitivity to detect early aging states and so, guarantying high memory reliability. Furthermore, area overhead due to sensor insertion is almost negligible.
Characterization of phage-coupled magnetoelastic micro-particles for the detection of Bacillus anthracis Sterne spores (2007)

A microfabricated magnetoelastic sensor immobilized with specific phage for the detection of Bacillus anthracis spores is presented. This micro-sensor can detect response signal remotely through magnetic field, enabling the in-situ measurement of target pathogens in aqueous environment. The sensor's surface was modified by selected phage which provides the binding ability to B. anthracis spores. When exposed to B. anthracis spore solution, the resonant frequency of the sensor decreased due to the accumulated spore attachment on the surface. Sensors with dimensions of 200 times 40 times 4 mum were employed in the tests of increasing concentrations (10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> cfu/ml) of B. anthracis spores. A detection limit of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> cfu/ml, and a sensitivity of 13.1 kHz/decade, were observed. Scanning electron microscopy (SEM) photographs demonstrated binding of target analytes to biosensors compared to controls.
Early and late integration of audio features for automatic video description (2017)

This paper presents our approach to improve video captioning by integrating audio and video features. Video captioning is the task of generating a textual description to describe the content of a video. State-of-the-art approaches to video captioning are based on sequence-to-sequence models, in which a single neural network accepts sequential images and audio data, and outputs a sequence of words that best describe the input data in natural language. The network thus learns to encode the video input into an intermediate semantic representation, which can be useful in applications such as multimedia indexing, automatic narration, and audio-visual question answering. In our prior work, we proposed an attention-based multi-modal fusion mechanism to integrate image, motion, and audio features, where the multiple features are integrated in the network. Here, we apply hypothesis-level integration based on minimum Bayes-risk (MBR) decoding to further improve the caption quality, focusing on well-known evaluation metrics (BLEU and METEOR scores). Experiments with the YouTube2Text and MSR-VTT datasets demonstrate that combinations of early and late integration of multimodal features significantly improve the audio-visual semantic representation, as measured by the resulting caption quality. In addition, we compared the performance of our method using two different types of audio features: MFCC features, and the audio features extracted using SoundNet, which was trained to recognize objects and scenes from videos using only the audio signals.
Low-Rank based Nonlocal Adaptive Loop Filter for High Efficiency Video Compression (2016)

In video coding, the in-loop filtering has emerged as a key module due to its significant improvement on compression performance since H.264/Advanced Video Coding. Existing incorporated in-loop filters in video coding standards mainly take advantage of the local smoothness prior model used for images. In this paper, we propose a novel adaptive loop filter utilizing image nonlocal prior knowledge by imposing the low-rank constraint on similar image patches for compression noise reduction. In the filtering process, the reconstructed frame is first divided into image patch groups according to image patch similarity. The proposed in-loop filtering is formulated as an optimization problem with low-rank constraint for every group of image patches independently. It can be efficiently solved by soft-thresholding singular values of the matrix composed of image patches in the same group. To adapt the properties of the input sequences and bit budget, an adaptive threshold derivation model is established for every group of image patches according to the characteristics of compressed image patches, quantization parameters, and coding modes. Moreover, frame-level and largest coding unit-level control flags are signaled to further improve the adaptability from the sense of rate-distortion optimization. The performance of the proposed in-loop filter is analyzed when it collaborates with the existing in-loop filters in High Efficiency Video Coding. Extensive experimental results show that our proposed in-loop filter can further improve the performance of state-of-the-art video coding standard significantly, with up to 16% bit-rate savings.
The Highly Conserved COOH Terminus of Troponin I Forms a Ca<sup>2+</sup>-Modulated Allosteric Domain in the Troponin Complex (2001)

The primary structure of the COOH-terminal region of troponin I (TnI) is highly conserved among the cardiac, slow, and fast skeletal muscle TnI isoforms and across species. Although no binding site for the other thin filament proteins is found at the COOH terminus of TnI, truncations of the last 19-23 amino acid residues reduce the activity of TnI in the inhibition of actomyosin ATPase and result in cardiac muscle malfunction. We have developed a specific monoclonal antibody (mAb), TnI-1, against the conserved COOH terminus of TnI. Using this mAb, isolation of the troponin complex by immunoaffinity chromatography from muscle homogenate and immunofluorescence microscopic staining of myofibrils indicate that the COOH terminus of TnI forms an exposed structure in the muscle thin filament. Binding of this mAb to the COOH terminus of cardiac TnI induced extensive conformational changes in the protein, suggesting an allosteric role of this region in the functional integrity of troponin. In the absence of Ca2+, the binding of troponin C and troponin T to TnI had very little effect on the conformation of the COOH terminus of TnI as indicated by the unaffected mAb affinity for the TnI-1 epitope. However, Ca2+ significantly increased the accessibility of the TnI-1 epitope on TnI in the presence of troponin C and troponin T. The results provide evidence that the COOH terminus is an essential structure in TnI and participates in the allosteric switch during Ca2+ activation of contraction.
Thermal stability of epitaxial SrRuO3 films as a function of oxygen pressure (2004)

The thermal stability of electrically conducting SrRuO3 thin films grown by pulsed-laser deposition on (001) SrTiO3 substrates has been investigated by atomic force microscopy and reflection high-energy electron diffraction (RHEED) under reducing conditions (25–800 °C in 10−7–10−2 Torr O2). The as-grown SrRuO3 epitaxial films exhibit atomically flat surfaces with single unit-cell steps, even after exposure to air at room temperature. The films remain stable at temperatures as high as 720 °C in moderate oxygen ambients (&gt;1 mTorr), but higher temperature anneals at lower pressures result in the formation of islands and pits due to the decomposition of SrRuO3. Using in situ RHEED, a temperature and oxygen pressure stability map was determined, consistent with a thermally activated decomposition process having an activation energy of 88 kJ/mol. The results can be used to determine the proper conditions for growth of additional epitaxial oxide layers on high quality electrically conducting SrRuO3.
A new sponge profile for retinal detachment surgery, design and in vitro‐effectiveness (1999)

The new design produces sufficient indentation combined with minor change of the outer globe contour. It has the potential to be as efficient as conventional round sponges, but more tolerable for the patient by reduction of form related side effects.
Dynamic behaviours of piston rings and their practical impact. Part 1: Ring flutter and ring collapse and their effects on gas flow and oil transport (2002)

This paper describes the physics of two major dynamic behaviours of the piston rings, namely ring flutter and ring collapse, and their effects on gas flow and oil transport. The analysis was conducted by applying a theoretical model in a spark ignition engine and a heavy-duty diesel engine. Parameters that have great influence on these dynamic behaviours are discussed for these two different types of engine and different rings. Specifically, the importance of ring twist, torsional stiffness and ring-groove clearance to ring flutter are discussed in detail. For ring radial collapse, the paper presents a simple formula that determines value of the critical parameters to eliminate ring radial collapse. Emphases are placed on the importance of mechanical designs in changing the performance of the piston ring pack in blowby and oil consumption.
Reactant supply in reactive ion etching (1979)

In reactive ion etching, the etch rate may be reactant limited, so that a measurement of reactant supply is neccessary to understand the details of the etching process. A quantitative determination of reactant supply can be obtained by measuring the total dissociation of the etching gas. In particular, this paper reports the total dissociation of CF4 as a function of input power and pressure in a diode system. A quadrupole mass spectrometer measuring the CF3+ peak indicates the presence of CF4 as well as other molecules containing the (CF3) radical. A transient technique is used to separate the contributions of the other molecules from CF4 so that the total CF4 number density can be calculated. The production of reactant by the dissociation of Cf4 causes etching of silicon and SiO2 on the cathode of the system. Possible reaction sequences of these etching processes are modelled by using the known supply of reactant. The partial pressures of the etching products are calculated and correlated with the etch rates and the rise in total pressure.
Co-Enzyme Q10 to Treat Neurological Disorders: Basic Mechanisms, Clinical Outcomes, and Future Research Direction (2013)

Coenzyme Q10 (CoQ10) is critical for the cell power supply in mitochondria. CoQ10 shuttles electrons from complexes I and II to complex III, and can be anti-oxdiative. Neurons require high energy for synaptic transmission and therefore the mitochondria dysfunction often leads to severe neuronal degeneration, as observed in many neurological disorders. CoQ10 supplementation has been widely used to treat aging, stroke, neuromuscular diseases, Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy, autosomal recessive cerebellar ataxias, Huntington's disease and amyotrophic lateral sclerosis. Here we discuss a large number of preclinical and clinical trials for CoQ10 to elucidate the mechanisms underlying CoQ10 therapy. The rational applications as a therapeutic agent in neurological disorders are discussed.
The role of plasmacytoid dendritic cells in IgE-mediated skin diseases (2006)

The high affinity receptor for IgE (FcεRI) on myeloid dendritic cells has been shown to play a major role in IgE-mediated skin diseases such as atopic dermatitis (AD). Plasmacytoid dendritic cells (pDC) which are instrumental in the defense of viral infections are present in reduced amounts in the skin of AD patients, which are characterized by a high susceptibility to viral infections. We explored phenotypical and functional characteristics of pDC in the peripheral blood of patients with AD and healthy individuals. BDCA2+CD123+ pDC have been enriched from the peripheral blood of patients with AD and studied in functional assays. Skin homing molecules and Toll-like receptor 9 were expressed in lower levels on pDC of patients with AD. PDC expressed high amounts of IgE-occupied FcεRI. Further on FcεRI-aggregation on pDC induced the production of interleukin-10 and enhanced the apoptosis of pDC. Importantly, FcεRI pre-activated pDC produced less IFN-αlphα; and IFN-β after stimulation with viral stimuli such as inactivated Herpes simplex Virus (HSV) and enhanced the outcome of immune responses of the Th2 type. In parallel, serum levels of Th2 cytokines were enhanced in patients with AD at risk for viral infections, while serum levels of type I and type II interferons were reduced. From these data we conclude that (i) FcεRI-bearing pDC from patients with AD are different from pDC of healthy individuals, (ii) might be important in the pathophysiology of AD and (iii) contribute to the enhanced susceptibility of AD patients to viral infections.
[Crocoite reduction by a culture of Pseudomonas chromatophila sp. nov]. (1979)

Two cultures of chromium reducing bacteria have been isolated from samples of water accumulated at the bottom of an open-cut chromium deposit and from industrial sewage. The cultures were found to be identical. The cultures are described and their taxonomical position is discussed. They have been classed as Psuedomonas chromatophila sp. nov. the cultures reduce Cr(VI) from crocoite PbCrO4 to Cr(III). A possibility of chromium reducing bacteria being involved in the conversion of crocoite to chromite in the oxidation zone of chromite deposits is discussed.