gebhart/patrepeval huggingface dataset:
Reduced tumorigenicity of murine tumor cells secreting gamma-interferon is due to nonspecific host responses and is unrelated to class I major histocompatibility complex expression. (1991)

Spontaneous SP1 murine adenocarcinoma cells transfected with the murine gamma-interferon (IFN-gamma) gene expressed IFN-gamma (SP1/IFN-gamma) failed to grow in syngeneic hosts and grew in nude mice. The rejection of SP1/IFN-gamma cells was related to the amount of IFN-gamma produced and appeared to be mediated primarily by nonspecific cellular mechanisms, although some role for T-cells in the afferent arm of this response is possible. SP1 cells are H2-Kk negative but express class I antigens when producing IFN-gamma. However, class I major histocompatibility complex (MHC) expression, while likely necessary, was insufficient in itself to prevent tumor growth since secretion of greater than 64 units/ml IFN-gamma was needed to inhibit tumorigenicity while only 8 units/ml IFN-gamma could induce class I antigens. Similar results were obtained with the murine colon carcinoma CT-26, a tumor that constitutively expresses class I MHC antigens, further supporting the contention that class I MHC expression is not essential for the rejection response induced by IFN-gamma. The failure of SP1/IFN-gamma cells to protect against a challenge with parent SP1 cells argues that factors other than IFN-gamma production or class I MHC expression are needed to induce a protective response against weakly or nonimmunogenic tumor cells.
Chemorheology of polymers (1979)

Chemorheology of polymers , Chemorheology of polymers , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Preliminary clinical study of transferrin-adriamycin conjugate for drug delivery to acute leukemia patients. (1990)

Seven patients with acute leukemia were treated intravenously with low doses of transferrin-Adriamycin conjugate. The total amount of drug given each patient was far below known toxicity levels for free Adriamycin. The number of tumor cells in peripheral blood diminished in treated patients, and bone marrow aspirates showed no evidence of disease progression. Two patients gave a febrile response and no hypersensitivity reactions were observed. Results of parallel basic research have shown that transferrin receptors on acute leukemia cells bind transferrin-Adriamycin conjugates, and kill by mechanisms at either the plasma membrane or nuclear levels, or both. Such conjugates may provide an alternative to monoclonal antibody drug targeting.
[Experimental choroidal neovascularization in the rat]. (1994)

We successfully produced, highly (78%) reproducible experimental choroidal neovascularization (ChNV) in the subretinal space of pigmented rats with intense diode laser photocoagulation. ChNV in the pigmented rat was characterized by rapid development of neovascular membrane and proliferation of retinal pigment epithelium in the subretinal space. This procedure may be useful as an experimental model for ChNV.
COMMAND TECHNIQUES FOR THE REMOTE CONTROL OF INTERPLANETARY SPACECRAFT (1962)

Discussion of the design and operation of command systems for remote control of interplanetary spacecraft
Identifying Technique Errors SELF-MONITORING OF BLOOD GLUCOSE IN THE HOME SETTING (1994)

1. Twenty-two study participants aged 65 and older were observed performing self-monitoring of blood glucose (SMBG) in their homes 3 to 4 weeks after initial meter instruction to identify elderly patients' technique errors in SMBG. Periodic evaluation of the elders' SMBG is vital for ongoing accurate results. 2. Overall, the elderly patients were able to perform the blood glucose test correctly. However, performing the quality control checks proved more difficult. The three most frequent errors included failure to check control solution expiration dates (86%), not shaking the vials of control solution (82%), and not verifying glucose control solution results (68%). 3. Further studies using larger samples and various populations are needed to further assess and document SMBG by the elderly patient. As the numbers of elders using SMBG increase, so does the need for research to promote the most appropriate and cost-effective education and evaluation of this self-care.
Vibration Signal Processing for Machine Failure Detection (1996)

In vibration signal processing for machine failure detection, techniques involving adaptive filters are gaining popularity. Techniques involving Griffith algorithm and adaptive noise cancellation (ANC) have been used in numerous situations and in this paper the application of ANC technique for processing bearing vibration signals are presented. Acoustic emission sensors utilising PZT ceramics are used fa the measurement of bearing signals for input into the adaptive filter. The results involving artificially seeded defects on rolling elements bearing operating at different speeds show the potential of using these techniques to suppress unwanted background noise and hence detecting the desired signals.
Effect of light on the liquid crystal transition temperatures of 4-(4-n-pentylphenyl)vinyl cyanide (1975)

Although 4-(4-n-pentylphenyl)vinyl cyanide gives a nematic mesophase of wide range (48·1°), this material would not be useful for electro-optic displays because of its light sensitivity; similar problems could arise with other mesogens involving the group –C6H4–CHCHCN.
A Screened Emitter Photoelectron Analyzer (1970)

A retarding field energy analyzer for photoelectron spectroscopy is improved by adding a screened field-free region around the emitter. For preliminary measurements on nickel, the analyzer error was estimated to be &lt;2.8% of the kinetic energy. The electronic circuit configuration which performed best is presented along with a description of spurious effects introduced by circuit variations.
An Improved Single-disk Method for Testing the Antibiotic Susceptibility of Rapidly-growing Pathogens (1970)

The Kirby-Bauer method of disk antibiotic-susceptibility tests is well standardized and accurate, but the method for standardizing the inoculum is rather time-consuming and is often impractical for routine use. This report describes a somewhat more practical, efficient method for inoculating the test plates. A calibrated inoculum obtained from a small volume of broth culture is spread over the agar surface with a seeded agar overlay. Comparison of this new method with the standardized Kirby-Bauer method shows that the zones of inhibition are nearly identical in size, and thus the same zone standards for interpretation can be applied to both methods. Because the inhibitory zone edges were better defined on plates inoculated with the agar-overlay method, there was a slightly better correlation between zone diameters and minimal inhibitory concentrations, especially with bacteriostatic drugs. Tests with swarming Proteus mirabilis were much more satisfactory with the agar-overlay method. The new technic is recommended as a routine method for testing the common Enterobacteriaceae, P. aeruginosa and S. aureus.
Molecular diagnosis of <i>ureaplasma urealyticum</i> septic arthritis in a patient with hypogammaglobulinemia (1992)

The PCR technique promises to be extremely valuable in the rapid and specific diagnosis of infectious arthritis.
A Study of Principle of Conversation in Advertising Language (2012)

Principle (PP). Advertising language can produce conversational implicatures and exert stronger persuasive effect by observing and violating the Cooperative Principle. At the same time, some public service advertisements comply with the Politeness Principle. The paper offers a wider way for advertising designers to create excellent advertisements and also make them pay attention to some problems existing in ads. On the other hand, it is also of great help for consumers to understand the implied meaning of advertisements and avoid being tempted into buying some poor quality products by some deceptive advertising.
Dynamic analyses of roll plane interconnected hydro-pneumatic suspension systems (2008)

Concepts in roll-interconnected hydro-pneumatic suspensions with hydraulic and pneumatic couplings are developed and analysed for enhancement of anti-roll properties of heavy vehicles. The mathematical models of the roll-coupled suspensions are formulated considering the fluid properties and variable damping valves. The roll properties of fluidically connected suspensions are compared with those of unconnected suspensions with and without anti-roll bar, and dynamic responses of a heavy vehicle with different suspensions are investigated under excitations arising from road roughness and directional manoeuvres. The results indicate that both interconnected suspensions could considerably improve roll stiffness without affecting vertical ride, while hydraulic interconnections could further enhance the roll mode damping properties.
Modelling an emergency vehicle early-warning system using real-time feedback (2008)

Emergency vehicles, while usually equipped with warning devices, are still often impeded by other traffic and involved in numerous collisions. Current research is investigating the use of wireless communication from emergency vehicles to warn other traffic. However, communication in dynamic wireless networks is not reliable. In this paper, we propose a novel emergency vehicle early-warning system that relies on wireless technology to inform other vehicles of the arrival of emergency vehicles, and returns feedback in real-time when communication degrades. We describe how such a system is built with Comhordu, a coordination model for wireless networks.
Photoelectrochemical cells based on photosynthetic systems: a review (2015)

Photosynthesis is a process which converts light energy into energy contained in the chemical bonds of organic compounds by photosynthetic pigments such as chlorophyll (Chl a, b, c, d, f) or bacteriochlorophyll. It occurs in phototrophic organisms, which include higher plants and many types of photosynthetic bacteria, including cyanobacteria. In the case of the oxygenic photosynthesis, water is a donor of both electrons and protons, and solar radiation serves as inexhaustible source of energy. Efficiency of energy conversion in the primary processes of photosynthesis is close to 100%. Therefore, for many years photosynthesis has attracted the attention of researchers and designers looking for alternative energy systems as one of the most efficient and eco-friendly pathways of energy conversion. The latest advances in the design of optimal solar cells include the creation of converters based on thylakoid membranes, photosystems, and whole cells of cyanobacteria immobilized on nanostructured electrode (gold nanoparticles, carbon nanotubes, nanoparticles of ZnO and TiO2). The mode of solar energy conversion in photosynthesis has a great potential as a source of renewable energy while it is sustainable and environmentally safety as well. Application of pigments such as Chl f and Chl d (unlike Chl a and Chl b), by absorbing the far red and near infrared region of the spectrum (in the range 700-750 nm), will allow to increase the efficiency of such light transforming systems. This review article presents the last achievements in the field of energy photoconverters based on photosynthetic systems.
The Organized Bar: A Catalyst for Court Reform (2025)

This Article theorizes that state and local bar associations can play a vital role in ridding their courts of excessive costs and delay. Theory can become practice, however, only if state and local bars are reorganized to broaden their oversight and lobbying functions, in order to make them more effective vehicles of reform. This Article, then, discusses the role the organized bar can and should play in achieving procedural reform that will reduce the delay and cost of litigation. Part I describes the various stages of the reform process, using the Kentucky experiment as a model, and outlines the contributions that can be made by bar associations at each stage. Part II sets out a structural model for bar associations that will enable the organized bar to become an effective and efficient court reform agent.
Combining sensitive database searches with multiple intermediates to detect distant homologues (1999)

Using data from the CATH structure classification, we have assessed the blastp, fasta, smith-waterman and gapped-blast algorithms, developed a portable normalization scheme and identified safe thresholds for database searching. Of the four methods assessed, fasta, smith-waterman and gapped-blast perform similarly, whereas the sensitivity of blastp was much lower. Introduction of an intermediate sequence search substantially improved the results. When tested on a set of relationships that could not be identified by blastp, intermediate sequences were able to find double the number of relationships identified by the smith-waterman algorithm alone. However, we found that the benefit of using intermediates varied considerably between each family and depended not only on the number of available sequences, but also their diversity. In an attempt to increase sensitivity further, a multiple intermediate sequence search (MISS) procedure was developed. When assessed on 1906 cases from a wide range of homologous families that could not be detected by the previous approaches, MISS was able to identify 241 additional relationships. MISS uses the full extent of sequence diversity to detect additional relationships, but does not consider any structure-specific information. For this reason, it is more generally applicable than fold recognition and threading methods, which require a library of known structures.
Consistent Osteoblastic Differentiation of Human Mesenchymal Stem Cells with Bone Morphogenetic Protein 4 and Low Serum (2010)

Providing fully mature and functional osteoblasts is challenging for bone tissue engineering and regenerative medicine. Such cells could be obtained from multipotent bone marrow mesenchymal stem cells (MSCs) after induction by different osteogenic factors. However, there are some discrepancies in results, notably due to the use of sera and to the type of osteogenic factor. In this study, we compared the osteogenic differentiation of bone marrow MSCs induced by dexamethasone (Dex) or bone morphogenetic proteins (BMPs) by assessing phenotypes in vitro and functional osteoblasts in vivo. Reducing the content of fetal calf serum from 10% to 2% significantly increased the mineral deposition and expression of osteoblastic markers during osteogenesis. In comparison to Dex condition, the addition of BMP4 greatly improved the differentiation of MSCs into fully mature osteoblasts as seen by high expression of Osterix. These results were confirmed in different supportive matrixes, plastic flasks, or biphasic calcium phosphate biomaterials. In contrast to Dex-derived osteoblasts, BMP4-derived osteoblasts from MSCs were significantly able to produce new bone in subcutis of nude mice in accordance with in vitro results. In conclusion, we describe a convenient ex vivo method to produce consistently mature functional osteoblasts from human MSCs with use of BMP4 and low serum.
Differential feeding by marine flagellates on growing versus starving, and on motile versus nonmotile, bacterial prey (1993)

Previous work has demonstrated selective feeding by bacterivorous protists on the basis of prey size. Other prey characteristics may also affect protist grazing rates. In this study, we investigated relative uptake rates of fluorescently labeled bacterial (FLB) cells made from growing (G-FLB) vs starving bacteria (S-FLB), and of live-stained motile vs non-motile bacteria by marine phagotrophic flagellates. We also determined relative growth rates and digestion times for flagellates fed growing or starved bacteria. A natural assemblage of marine flagellates and a flagellate isolate, Cafeteria sp., showed lower (p < 0.001) clearance rates on S-FLB than on G-FLB, which could be ascribed to sizeselective grazing by the flagellates. Moreover, flagellates showed longer (p < 0.001) prey digestion tmes when feedng on S-FLB than on G-FLB. The carbon-based gross growth efficiency of flagellates fed starved bacteria was nearly twice that of flagellates fed growing bacteria: 38.5% and 21.5%, respectively. Uptake rates by flagellates of several live-stained bacteria (LSB) of either motile or nonmotlle strains were compared with uptake rates of heat-killed FLB made from the same bacterial cultures. Clearance rates were significantly higher for LSB compared to FLB only for motile strains; no differences in uptake rates were observed for non-motile bacteria. Although FLB may be a good tracer for non-motile bacteria, use of FLB may lead to underestimation of actual grazing rates if motile bacteria comprise a significant fraction of the total bacterial assemblage. Our results suggest (1) grazing on starved bacteria results in a more efficient transfer of biomass to higher trophic levels than does grazing on growing bacteria; (2) use of motile LSB in prey uptake experiments should yield higher estimates of bacterivory compared to rates estimated using heat-killed or non-motile labeled prey; and (3) quahtative factors affecting predator-prey dynamics may be important in regulating elemental fluxes in microbial food webs.
Design and Development of the Vision Sorting System (2016)

Sorting is one of the important tasks in production line and it has an appreciable effect to the homogeneous of products. Using vision system to increase productivity in automatic sorting system interests a large of researchers. In this paper, we recommend a vision sorting system based on computer that can identify the position and properties of fruits. The sorting system uses the high resolution camera placed on the top of the mechanical conveyor belt. With the images captured by the camera, the software will perform the algorithms to identify the characteristics of the object (ei. tomatoes, passion fruits) to sort and give the location of sorted objects to database, the data of objects can be used by pick and place process that synchronize with controller of the actuators. The sorting process comprising the steps of: detecting the object, determine the object properties as color, size, shape,..., locate the sorted object, calculate the actual gripping position, the results of the sorting process will be stored and converted into signals to communicate with the control system of actuators to perform the sorting tasks. The algorithms will be experimented on tomatoes and passion fruits, results will be analyzed and evaluated to calculate the stable of the vision system, so that the productivity and accurate efficiency is appropriate.
Network exception handlers (2008)

Enterprise network architecture and management have followed the Internet's design principles despite different requirements and characteristics: enterprise hosts are administered by a single authority, which intrinsically assigns different values to traffic from different business applications. We advocate a new approach where hosts are no longer relegated to the network's periphery, but actively participate in network-related decisions. To enable host participation, network information, such as dynamic network topology and per-link characteristics and costs, is exposed to the hosts, and network administrators specify conditions on the propagated network information that trigger actions to be performed while a condition holds. The combination of a condition and its actions embodies the concept of the network exception handler, defined analogous to a program exception handler. Conceptually, network exception handlers execute on hosts with actions parameterized by network and host state. Network exception handlers allow hosts to participate in network management, traffic engineering and other operational decisions by explicitly controlling host traffic under predefined conditions. This flexibility improves overall performance by allowing efficient use of network resources. We outline several sample network exception handlers, present an architecture to support them, and evaluate them using data collected from our own enterprise network.
SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis (2012)

Tumors exhibit metabolic reprogramming characterized by increased cellular reactive oxygen species (ROS) and the preferential use of glucose, which is known as the Warburg effect. However, the mechanisms by which these processes are linked remain largely elusive. Murine tumors lacking Sirt3 exhibit abnormally high levels of ROS that directly induce genomic instability and increase hypoxia-inducible factor 1α (HIF-1α) protein levels. The subsequent transcription of HIFα-dependent target genes results in cellular metabolic reprogramming and increased cellular glucose consumption. In addition, agents that scavenge ROS or reverse the Warburg effect prevent the transformation and malignant phenotype observed in cells lacking Sirt3. Thus, mice lacking Sirt3 provide a model that mechanistically connects aberrant ROS, the Warburg effect, and carcinogenesis.
Isolated hepatic perfusion with high-dose melphalan for the treatment of uveal melanoma metastases confined to the liver (2004)

Uveal melanoma is the most common primary intraocular tumour in adults. After treatment of the primary tumour, up to 50% of patients will ultimately develop metastases. Treatment options for metastases are limited. When uveal melanoma metastases are confined to the liver, isolated hepatic perfusion (IHP) could be a treatment option. Herein, we report the results of a small group of patients with uveal melanoma metastases of the liver treated with IHP. Eight patients with uveal melanoma metastases confined to the liver underwent IHP with high-dose melphalan (200 mg) for 1 h. Toxicity was graded according to the National Cancer Institute Common Toxicity Criteria and tumour response was assessed according to World Health Organization criteria. The tumour response rate (complete or partial remission) was 50%. The median time to progression was 6.7 months (range, 1.7-16.9 months). The overall median survival was 9.9 months (range, 4.7-34.6 months), with a 1 year survival of 50% and a 2 year survival of 37.5%. Three patients experienced grade 3-4 hepatotoxicity which was transient within 3 months. Although only a small group of patients has been treated and evaluated so far, IHP is a treatment option for uveal melanoma metastases confined to the liver which can result in tumour responses and may lead to survival benefits in a selective group of patients.
Silicon Resonator Based 3.2 $\mu$W Real Time Clock With $\pm$10 ppm Frequency Accuracy (2010)

This paper presents an ultra-low power generic compensation scheme that is used to implement a real time clock based on an AlN-driven 1 MHz uncompensated silicon resonator achieving 3.2 μW power dissipation at 1 V and ±10 ppm frequency accuracy over a 0-50°C temperature range. It relies on the combination of fractional division and frequency interpolation for coarse and fine tuning respectively. By proper calibration and application of temperature dependent corrections, any frequency below that of the uncompensated resonator can be generated yielding programmability, resonator fabrication tolerances and temperature drift compensation without requiring a PLL. To minimize the IC area, a dual oscillator temperature measurement concept based on a ring oscillator/resistor thermal sensor was implemented yielding a resolution of 0.04°C. The IC was fabricated on a 0.18 μm 1P6M CMOS technology.