gebhart/patrepeval huggingface dataset:
Catechol-Functionalized Chitosan/Iron Oxide Nanoparticle Composite Inspired by Mussel Thread Coating and Squid Beak Interfacial Chemistry (2013)

Biological materials offer a wide range of multifunctional and structural properties that are currently not achieved in synthetic materials. Herein we report on the synthesis and preparation of bioinspired organic/inorganic composites that mimic the key physicochemical features associated with the mechanical strengthening of both squid beaks and mussel thread coatings using chitosan as an initial template. While chitosan is a well-known biocompatible material, it suffers from key drawbacks that have limited its usage in a wider range of structural biomedical applications. First, its load-bearing capability in hydrated conditions remains poor, and second it completely dissolves at pH < 6, preventing its use in mild acidic microenvironments. In order to overcome these intrinsic limitations, a chitosan-based organic/inorganic biocomposite is prepared that mimics the interfacial chemistry of squid beaks and mussel thread coating. Chitosan was functionalized with catechol moieties in a highly controlled fashion and combined with superparamagnetic iron oxide (γ-Fe2O3) nanoparticles to give composites that represent a significant improvement in functionality of chitosan-based biomaterials. The inorganic/organic (γ-Fe2O3/catechol) interfaces are stabilized and strengthened by coordination bonding, resulting in hybrid composites with improved stability at high temperatures, physiological pH conditions, and acid/base conditions. The inclusion of superparamagnetic particles also makes the composites stimuli-responsive.
Analysis of Methyl Methacrylate Copolymers by Gas Chromatography (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalysis of Methyl Methacrylate Copolymers by Gas ChromatographyJohn. Strassburger, G. M. Brauer, Max. Tryon, and A. F. ForziatiCite this: Anal. Chem. 1960, 32, 4, 454–457Publication Date (Print):April 1, 1960Publication History Published online1 May 2002Published inissue 1 April 1960https://pubs.acs.org/doi/10.1021/ac60160a002https://doi.org/10.1021/ac60160a002research-articleACS PublicationsRequest reuse permissionsArticle Views292Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Motion detection of an interlaced video signal (1994)

This paper describes an advanced algorithm for motion detection from an interlaced video signal, such as PAL or NTSC. A general comparative analysis of motion detectors utilizing one, two, and three field memories is presented. As a potential application, television scan rate conversion, e.g. deinterlacing, is considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effect of a Vitamin D3 Analogue on Keratinocyte Growth Factor-Induced Cell Proliferation in Benign Prostate Hyperplasia (2000)

Prostate enlargement and function is under the dual control of androgens and intraprostatic growth factors. They regulate, in concert, prostate cell proliferation and apoptosis. An increased signaling of both growth factors and androgens are supposed to underlie benign prostate hyperplasia (BPH), one of the more common disorders of the aging male. Since, in clinical practice, androgen ablation resulted in a rather limited decrease in prostate volume, therapeutic strategies targeting intraprostatic growth factors are emerging. The activated form of vitamin D, vitamin D-3, and some of its analogues have been described as potent regulators of cell growth and differentiation. In this study, we report the effects of one of these vitamin D, analogues, 1,25-dihydroxy-16ene-23yne D-3, or analogue (V), on the fate of isolated epithelial cells derived from patients with BPH. We essentially found that analogue (V), as well as vitamin D-3, inhibited BPH cell proliferation and counteracted the mitogenic activity of a potent growth factor for BPH cells, such as keratinocyte growth factor (KGF). Moreover, analogue (V) induced bcl-2 protein expression, intracellular calcium mobilization, and apoptosis in both unstimulated and KGF-stimulated BPH cells. Since a short-term (5-min) incubation with analogue (V) reduced the KGF-induced tyrosine phosphorylation of a 120-kDA protein, corresponding to the KGF receptor, a rapid and direct cross-talk between these two molecules is suggested. Such a rapid effect of analogue (V), together with the transient induction of intracellular calcium waves, seems to indicate the partial involvement of a membrane, nongenomic receptor for vitamin D-3. In conclusion, we demonstrated the antiproliferative and proapoptotic effect of analogue (V) in BPH cells and speculated on its possible use in the therapy of BPH.
Understanding Energy Aspects of Processing-near-Memory for HPC Workloads (2015)

Interests in the concept of processing-near-memory (PNM) have been reignited with recent improvements of the 3D integration technology. In this work, we analyze the energy consumption characteristics of a system which comprises a conventional processor and a 3D memory stack with fully-programmable cores. We construct a high-level analytical energy model based on the underlying architecture and the technology with which each component is built. From the preliminary experiments with 11 HPC benchmarks from Mantevo benchmark suite, we observed that misses per kilo instructions (MPKI) of last-level cache (LLC) is one of the most important characteristics in determining the friendliness of the application to the PNM execution.
Les micro-territoires dans l'aménagement urbain, objets spatiaux et sociaux paradoxaux (2004)

Si les differentes dimensions de la recomposition territoriale des villes europeennes sont individuellement bien identifiees, en particulier en ce qui concerne leur extension materielle et le renouvellement de leurs structures d’organisation, elles restent neanmoins difficiles a penser dans un meme geste. Partant de cette idee, cet article fait le pari que l’analyse de l’amenagement d’un micro-territoire est a meme de constituer un analyseur efficace des logiques urbaines plus vastes telles qu’elles s’expriment et peuvent etre observees dans le cas d’une ville intermediaire, Orleans.
Interactive Word Alignment for Corpus Linguistics (2003)

In this paper an incremental method and an interactive tool to improve the performance of word alignment are presented. The most important factor in our proposal is to put a human in the alignment loop. This is achieved by using interactive word alignment, i.e., a word alignment system and a human that are collaborating in order to make word alignment as efficient and accurate as possible. The aim is full coverage alignments with high accuracy, as the quality of word alignments is crucial in many applications within corpus linguistics, for example, in lexicography, contrastive linguistics and translation studies. 1
Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation (2017)

TDP-43 is a primarily nuclear RNA-binding protein, whose abnormal phosphorylation and cytoplasmic aggregation characterizes affected neurons in patients with amyotrophic lateral sclerosis and frontotemporal dementia. Here, we report that physiological nuclear TDP-43 in mouse and human brain forms homo-oligomers that are resistant to cellular stress. Physiological TDP-43 oligomerization is mediated by its N-terminal domain, which can adopt dynamic, solenoid-like structures, as revealed by a 2.1 Å crystal structure in combination with nuclear magnetic resonance spectroscopy and electron microscopy. These head-to-tail TDP-43 oligomers are unique among known RNA-binding proteins and represent the functional form of the protein in vivo, since their destabilization results in loss of alternative splicing regulation of known neuronal RNA targets. Our findings indicate that N-terminal domain-driven oligomerization spatially separates the adjoining highly aggregation-prone, C-terminal low-complexity domains of consecutive TDP-43 monomers, thereby preventing low-complexity domain inter-molecular interactions and antagonizing the formation of pathologic aggregates.TDP-43 aggregation is observed in amyotrophic lateral sclerosis. Here the authors combine X-ray crystallography, nuclear magnetic resonance and electron microscopy studies and show that physiological oligomerization of TDP-43 is mediated through its N-terminal domain, which forms functional and dynamic oligomers antagonizing pathologic aggregation.
Selective Functionalization of 3-D Polymer Microstructures (2006)

We demonstrate the selective functionalization of 3-D polymer microstructures that were created using multiphoton absorption polymerization. By fabricating different portions of the structures with acrylic and methacrylic polymers, we are able to take advantage of the differential reactivities of these materials to perform functionalization chemistry on a single polymeric component. We demonstrate the selective deposition of metal to create structures, such as a functional microinductor. Our strategy is quite general and can be extended readily to the deposition of materials, such as metal oxides and biomolecules.
Multiple-Valued Logic For Optoelectronics (1986)

Recent advances in optical bistability in a variety of materials and devices offer the potential for high speed operation over extended ranges of wavelength and temperature. The advantages of optoelec-tronic devices and multiple-valued logic are combined in various multistable solid-state device techniques, of which negative resistance multistability is most compatible with utilization of bistable optoelec-tronic devices. Additional stable states result from negative resistance interactions and facilitate implementation of variable radix analog and digital applications. Needed characteristics of bistable optical devices are outlined for compatibility with multiple-valued logic implementation. Multiple-valued optical logic offers synergistic potential for improved performance.
Lewis Acid Activated Synthesis of Highly Substituted Cyclopentanes by the N‐Heterocyclic Carbene Catalyzed Addition of Homoenolate Equivalents to Unsaturated Ketoesters (2011)

A great team: Cyclopentanes with four contiguous stereogenic centers were assembled with excellent diastereo- and enantioselectivity from simple β,γ-unsaturated α-ketoesters and enals in a reaction catalyzed by an N-heterocyclic carbene (NHC) and mediated by a titanium(IV) Lewis acid (see scheme). The presence of a Lewis acid was essential for the desired transformation to occur. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Effect of Topical Antibiotic Solutions on Corneal Epithelial Wound Healing (1983)

The eight topical antibiotic solutions that we use most frequently were tested for their effect on corneal epithelial wound healing in the rabbit. Five percent cefazolin sodium and a mixture of neomycin sulfate, polymyxin B sulfate, and gramicidin (Neosporin) had the least effect on epithelial healing rates and quality of healing, 10% sulfacetamide sodium and an artificial tear had intermediate effects, and gentamicin sulfate, tobramycin, and chloramphenicol were the most toxic. No substantial differences were found between gentamicin and the newer aminoglycoside, tobramycin, and the "fortified" preparations of these two drugs did not seem to be more toxic than the 0.3% solutions. Therefore, topical antibiotic solutions vary in their effects on the corneal epithelium, and not all antibiotics should be considered innocuous when used in the treatment of epithelial defects.
Sulfated Glycoconjugates as Disrupters of Plasmodium Falciparum Erythrocyte Rosettes (1994)

Some strains of Plasmodium falciparum form erythrocyte rosettes that are believed to result from a lectin interaction between malaria-infected and uninfected erythrocytes. The sulfated glycoconjugate heparin and certain heparin derivatives have been observed to disrupt rosettes. To investigate this interaction further, we have studied the effects of four sulfated glycoconjugates on 15 fresh isolates of P. falciparum from Papua New Guinea. A broader range of sulfated glycoconjugates has been tested against a laboratory strain. A concentration of 1,000 micrograms/ml of dextran sulfate (molecular weight [MW] 500,000) was the most potent disrupter of rosettes. Fucoidan, heparin, and dextran sulfate (MW 5,000) were of decreasing effectiveness in 14 of 15 fresh isolates. The same relationship was true for the laboratory strain. Pentosan polysulfate and sulfatide also disrupted rosettes; chondroitin sulfates A, B, and C and keratan sulfate gave either minimal or no rosette disruption. Thus, some sulfated glycoconjugates are potent disrupters of P. falciparum erythrocyte rosettes. Sulfated glycoconjugates that are potent disrupters of P. falciparum rosettes may prove useful in identifying ligands involved in rosette formation.
Statistical Models of the Effects of Tree Trimming on Power System Outages (2006)

This paper develops statistical models for estimating the impacts of tree trimming on electric power system outages under normal (nonstorm) operating conditions. The models are based on an extensive data set from Duke Power, a company in the southeastern U.S., and the models used are a negative binomial generalized linear model and a Poisson generalized linear mixed model (GLMM). The results show that: 1) increasing tree trimming frequency does lead to a decrease in the number of outages on the electric power distribution system; 2) the effects of tree trimming on different circuits can be differentiated and measured; and 3) the Poisson GLMM provides a good fit to the data in this situation. In particular, the results of the model show that for the Duke Power system, one would have expected, on average, 0.9 fewer outages per circuit over the 43-month data recording period if the time between tree trimming cycles was decreased by 1 yr across the whole system. These models could be applied to other power systems, and the results should be useful for power managers in setting tree trimming frequencies and in focusing on the most frequent trimming efforts on those circuits for which trimming will have the greatest benefit.
Variability in the interpretation of screening mammograms by US radiologists. Findings from a national sample. (1996)

Our findings indicate that there is wide variability in the accuracy of mammogram interpretation in the population of US radiologists. Current accreditation programs that certify the technical quality of radiographic equipment and images but not the accuracy of the interpretation given to mammograms may not be sufficient to help mammography fully realize its potential to reduce breast cancer mortality.
A near optimal isosurface extraction algorithm using the span space (1996)

Presents the "Near Optimal IsoSurface Extraction" (NOISE) algorithm for rapidly extracting isosurfaces from structured and unstructured grids. Using the span space, a new representation of the underlying domain, we develop an isosurface extraction algorithm with a worst case complexity of o(/spl radic/n+k) for the search phase, where n is the size of the data set and k is the number of cells intersected by the isosurface. The memory requirement is kept at O(n) while the preprocessing step is O(n log n). We utilize the span space representation as a tool for comparing isosurface extraction methods on structured and unstructured grids. We also present a fast triangulation scheme for generating and displaying unstructured tetrahedral grids.
A General Synthesis for 4-Alkyl-2,3-dihydrofurans (1984)

Synthese par alkylation en 3 d'oxo-2 perhydro furoate-3 d'ethyle suivie de desalcoxycarbonylation puis de reduction de la fonction cetone en fonction alcool et de deshydratation
Di-tert-butylcyclopentadiene and tri-tert-butylcyclopentadiene (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDi-tert-butylcyclopentadiene and tri-tert-butylcyclopentadieneClifford G. Venier and Edward W. CasserlyCite this: J. Am. Chem. Soc. 1990, 112, 7, 2808–2809Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/ja00163a057https://doi.org/10.1021/ja00163a057research-articleACS PublicationsRequest reuse permissionsArticle Views2000Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lithium and Suicide Risk in Bipolar Disorder (2000)

Abstract Can timely diagnosis and treatment of depression reduce the risk of suicide? Studies of treatment effects on mortality in major mood disorders remain rare and are widely considered difficult to carry out ethically. Despite close associations of suicide with major affective disorders and related comorbidity, the available evidence provides little support for sustained reductions of suicide risk by most mood-altering treatments, including antidepressants. Studies designed to evaluate clinical benefits of mood-stabilizing treatments in bipolar disorders, however, provide comparisons of suicidal rates with and without treatment or under different treatment conditions. This emerging body of research provides consistent evidence of reduced rates of suicides and attempts during long-term treatment with lithium. This effect may not generalize to proposed alternatives, particularly carbamazepine. Our recent international collaborative studies found compelling evidence for prolonged reduction of suicidal risks during treatment with lithium, as well as sharp increases soon after its discontinuation, all in close association with depressive recurrences. Depression was markedly reduced, and suicide attempts were less frequent, when lithium was discontinued gradually. These findings indicate that studies of the effects of long-term treatment on suicide risk are feasible and that more timely diagnosis and treatment for all forms of major depression, but particularly for bipolar depression, should further reduce suicide risk.
Chemical and Biological Warfare: Should Rapid Detection Techniques Be Researched To Dissuade Usage? A Review (2005)

Chemistry, microbiology and genetic engineering have opened new doorways for the human race to propel itself to a better future. However, there is a darker side to Bioengineering. One element of this is the manufacture and proliferation of biological and chemical weapons. It is clearly in the interest of humankind to prevent the future use of such weapons of mass destruction. Though many agents have been proposed as potential biological and chemical weapons, the feasibility of these weapons is a matter of conjecture. The unpredictable and indiscriminate devastation caused by natural epidemics and hazardous chemicals during wartime without medical treatment should warn humans of the dangers of employing them as weapons. This study argues rapid detection techniques may dissuade future use. Many agents are far less toxic to treatment. A quick response time to most attacks will decrease the chances of serious health issues. The agent will be less effective and discourage the attacker from using the weapon. Fortunately, the Chemical and Biological Weapons Convention (CWCIBWC) allows defensive work in the area of biological and chemical weapons. Consequently, the review will discuss history, delivery/dispersal systems and specific agents of the warfare. The study presents current developments in biosensors for toxic materials of defense interest. It concludes with future directions for biosensor development.
Synthesis of Enantiomerically Purecis-Cyclopropylboronic Esters (2000)

Highly stable, enantiomerically pure cyclopropylboronic esters are desirable building blocks for the preparation of a plethora of different cyclopropane derivatives. Whereas trans-configured compounds proved to be readily available, we herein report the first synthesis of the corresponding cis-cyclopropanes. The scope and limitation of this process will be discussed. The absolute configuration of the products could be established by means of chemical and spectroscopic correlation.
Partial offloading of OpenFlow rules on a traditional hardware switch ASIC (2017)

OpenFlow represents a new powerful paradigm that combines the flexibility of the software with the efficiency of a programmable hardware switch. However, such an approach is currently reserved for new hardware devices, specifically engineered for this paradigm. This paper presents our experience and findings about selectively offloading OpenFlow rules into a non-OpenFlow compatible hardware switch silicon, which enables existing (legacy) hardware ASIC's to become compatible with the SDN paradigm. We describe our solution that transparently offloads the portion of OpenFlow rules supported by the hardware while keeping in software the remaining ones, and that is able to support the presence of multiple hardware tables although with limited capabilities in terms of matches and actions. Moreover, we illustrate the design choices used to implement all the basic functionalities required by the OpenFlow protocol (e.g., packet-in, packet-out messages) and then wwe demonstrate the considerable advantage in terms of performance that can be obtained by performing switching in hardware, while maintaining an SDN-type ability to program and to instantiate desired network operations from a central controller.