gebhart/patrepeval huggingface dataset:
909: Update of Survival Data for Two Phase II Studies with Monoclonal Antibody CG250 (Rencarex®) in Combination with IL-2 or IFN Alpha-2A in Metastatic Renal Cell Cancer Patients (2007)

You have accessJournal of UrologyModerated Poster 26, Monday, May 21, 2007, 1:00 - 3:00 pm1 Apr 2007909: Update of Survival Data for Two Phase II Studies with Monoclonal Antibody CG250 (Rencarex®) in Combination with IL-2 or IFN Alpha-2A in Metastatic Renal Cell Cancer Patients Norman G. Neville, Pia Kloepfer, Paul Bevan, Carola Mala, Joachim Beck, Rainer Hofmann, Manfred Kindler, Peter F. Mulders, Michael Siebels, and R. Oberneder Norman G. NevilleNorman G. Neville More articles by this author , Pia KloepferPia Kloepfer More articles by this author , Paul BevanPaul Bevan More articles by this author , Carola MalaCarola Mala More articles by this author , Joachim BeckJoachim Beck More articles by this author , Rainer HofmannRainer Hofmann More articles by this author , Manfred KindlerManfred Kindler More articles by this author , Peter F. MuldersPeter F. Mulders More articles by this author , Michael SiebelsMichael Siebels More articles by this author , and R. ObernederR. Oberneder More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31137-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "909: Update of Survival Data for Two Phase II Studies with Monoclonal Antibody CG250 (Rencarex®) in Combination with IL-2 or IFN Alpha-2A in Metastatic Renal Cell Cancer Patients." The Journal of Urology, 177(4S), pp. 301–302 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 301-302 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Norman G. Neville More articles by this author Pia Kloepfer More articles by this author Paul Bevan More articles by this author Carola Mala More articles by this author Joachim Beck More articles by this author Rainer Hofmann More articles by this author Manfred Kindler More articles by this author Peter F. Mulders More articles by this author Michael Siebels More articles by this author R. Oberneder More articles by this author Expand All Advertisement PDF downloadLoading ...
Determination of fatty acids using solid phase microextraction (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of fatty acids using solid phase microextractionLin. Pan, Marc. Adams, and Janusz. PawliszynCite this: Anal. Chem. 1995, 67, 23, 4396–4403Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/ac00119a031https://doi.org/10.1021/ac00119a031research-articleACS PublicationsRequest reuse permissionsArticle Views1841Altmetric-Citations164LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optical phase shifting with acousto-optic devices (2005)

A novel optical phase-shifting method based on a well-known acousto-optic interaction is proposed. By using a pair of acousto-optic modulators (AOMs) and properly aligning them, we construct an optical phase shifter that can directly control the phase of a collimated beam. The proposed phase shifter is insensitive to the polarization of the incident beam when polarization-insensitive AOMs are used, and no calibration is necessary. The proposed approach is confirmed with experimental results.
New Methodologies for SET Characterization and Mitigation in Flash-Based FPGAs (2007)

New single event transient characterization and mitigation techniques unique for nonvolatile field programmable gate arrays (FPGAs) are investigated. Their implementation on a flash-based FPGA and evaluation in-beam show their efficacy with little area overhead but moderately high time penalty for highly scaled technologies.
Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism (2012)

COP9 signalosome (CSN) mediates deconjugation of the ubiquitin-like protein Nedd8 from the cullin subunits of SCF and other cullin-RING ubiquitin ligases (CRLs). This process is essential to maintain the proper activity of CRLs in cells. Here, we report a detailed kinetic characterization of CSN-mediated deconjugation of Nedd8 from SCF. CSN is an efficient enzyme, with a k(cat) of ~1 s(-1) and K(m) for neddylated Cul1-Rbx1 of ~200 nm, yielding a k(cat)/K(m) near the anticipated diffusion-controlled limit. Assembly with an F-box-Skp1 complex markedly inhibited deneddylation, although the magnitude varied considerably, with Fbw7-Skp1 inhibiting by ~5-fold but Skp2-Cks1-Skp1 by only ~15%. Deneddylation of both SCF(Fbw7) and SCF(Skp2-Cks1) was further inhibited ~2.5-fold by the addition of substrate. Combined, the inhibition by Fbw7-Skp1 plus its substrate cyclin E was greater than 10-fold. Unexpectedly, our results also uncover significant product inhibition by deconjugated Cul1, which results from the ability of Cul1 to bind tightly to CSN. Reciprocally, CSN inhibits the ubiquitin ligase activity of deneddylated Cul1. We propose a model in which assembled CRL complexes engaged with substrate are normally refractory to deneddylation. Upon consumption of substrate and subsequent deneddylation, CSN can remain stably bound to the CRL and hold it in low state of reduced activity.
β-Lactamase can function as a reporter of bacterial protein export during Mycobacterium tuberculosis infection of host cells (2007)

Mycobacterium tuberculosis is an intracellular pathogen that is able to avoid destruction by host immune defences. Exported proteins of M. tuberculosis, which include proteins localized to the bacterial surface or secreted into the extracellular environment, are ideally situated to interact with host factors. As a result, these proteins are attractive candidates for virulence factors, drug targets and vaccine components. Here we describe a beta-lactamase reporter system capable of identifying exported proteins of M. tuberculosis during growth in host cells. Because beta-lactams target bacterial cell-wall synthesis, beta-lactamases must be exported beyond the cytoplasm to protect against these drugs. When used in protein fusions, beta-lactamase can report on the subcellular location of another protein as measured by protection from beta-lactam antibiotics. Here we demonstrate that a truncated TEM-1 beta-lactamase lacking a signal sequence for export ('BlaTEM-1) can be used in this manner directly in a mutant strain of M. tuberculosis lacking the major beta-lactamase, BlaC. The 'BlaTEM-1 reporter conferred beta-lactam resistance when fused to both Sec and Tat export signal sequences. We further demonstrate that beta-lactamase fusion proteins report on protein export while M. tuberculosis is growing in THP-1 macrophage-like cells. This genetic system should facilitate the study of proteins exclusively exported in the host environment by intracellular M. tuberculosis.
A CMOS image sensor for high-speed active range finding using column-parallel time-domain ADC and position encoder (2003)

In this paper, a smart image sensor for real-time and high-resolution three-dimensional (3-D) measurement to be used for sheet light projection is presented. It realizes not only a sufficiently high frame rate for real-time 3-D measurement, but also high pixel resolution due to a small pixel circuit and high subpixel accuracy due to gravity center calculation using an intensity profile. Simulation results show that the ultimate frame rate is 32.6 k frames/s (i.e., 31.8 range/spl I.bar/map/s) in a 1024/spl times/1024 pixel sensor. A 3-b intensity profile allows subpixel accuracy under 0.1 pixel. The sensor using this architecture can acquire a two-dimensional (2-D) image as well, so a texture-mapped 3-D image can be reproduced by the same sensor. A 128/spl times/128 smart image sensor has been developed and successfully tested. A 2-D image, a range map, and a texture-mapped 3-D image have been acquired by the 3-D measurement system using the fabricated sensor.
Phonology and Syntax: The Relation between Sound and Structure (1984)

A fundamentally new approach to the theory of phonology and its relation to syntax is developed in this book, which is the first to address the question of the relation between syntax and phonology in a systematic way.This general theory differs from its predecessors in the generative tradition in several respects. By arguing that the intonational structure of a sentence determines certain aspects of its stress pattern or structure, and not vice versa, it provides a novel view of the intonation-stress relation. It also offers a new theory of the focus-prosody relation that solves a variety of classic puzzles and involves an appeal to the place of a focused constituent in the predicate-argument structure of the sentence. The book also includes other novel features, among them a development of the metrical grid theory of stress (including a complete treatment of English word stress in this framework), the representation of juncture in terms of silent positions in the metrical grid (with a treatment of sandhi in terms of this juncture), and a rhythmic nonsyntactic approach to the basic phonology of function words in EnglishElisabeth 0. Selkirk is Professor of Linguistics at the University of Massachusetts, Amherst. This book is tenth in the series, Current Studies in Linguistics.
Influenza Vaccination Accelerates Recovery of Ferrets from Lymphopenia (2014)

Ferrets are a useful animal model for human influenza virus infections, since they closely mimic the pathogenesis of influenza viruses observed in humans. However, a lack of reagents, especially for flow cytometry of immune cell subsets, has limited research in this model. Here we use a panel of primarily species cross-reactive antibodies to identify ferret T cells, cytotoxic T lymphocytes (CTL), B cells, and granulocytes in peripheral blood. Following infection with seasonal H3N2 or H1N1pdm09 influenza viruses, these cell types showed rapid and dramatic changes in frequency, even though clinically the infections were mild. The loss of B cells and CD4 and CD8 T cells, and the increase in neutrophils, were especially marked 1-2 days after infection, when about 90% of CD8+ T cells disappeared from the peripheral blood. The different virus strains led to different kinetics of leukocyte subset alterations. Vaccination with homologous vaccine reduced clinical symptoms slightly, but led to a much more rapid return to normal leukocyte parameters. Assessment of clinical symptoms may underestimate the effectiveness of influenza vaccine in restoring homeostasis.
Mixture Particle Filter for Low Cost INS/Odometer/GPS Integration in Land Vehicles (2009)

Global Positioning System (GPS) is currently the common solution for land vehicle positioning. However, GPS signals may suffer from blockage in urban canyons and tunnels, and the positioning information provided is interrupted. One solution to have continuous vehicle positioning is to integrate GPS with an inertial measurement unit (IMU) and the navigation solution is achieved using an estimation technique which is traditionally based on Kalman filter (KF). In order to have a low cost navigation solution for land vehicles, MEMS-based inertial sensors are used. To achieve a better performance during GPS outages, the speed derived from the vehicle odometer is used as a measurement update. To improve the positioning accuracy of the MEMS-based INS/Odometer/GPS integration, particle filtering (PF) is used as a nonlinear filtering technique, which does not need to linearize the models as in Extended KF (EKF). Because of PF ability to deal with nonlinear models, it can accommodate arbitrary sensor characteristics and motion dynamics. An enhanced version of PF is used which is called Mixture PF. While the Sampling/Importance Resampling (SIR) PF samples from the prior importance density and the Likelihood PF samples from the observation likelihood, the Mixture PF samples from both densities, then appropriate weighting is achieved followed by resampling. This mixture of importance densities leads to a better performance. The performance of this method is examined by road test trajectories in a land vehicle and compared to KF.
End-to-End Automatic Speech Translation of Audiobooks (2018)

We investigate end-to-end speech-to-text translation on a corpus of audiobooks specifically augmented for this task. Previous works investigated the extreme case where source language transcription is not available during learning nor decoding, but we also study a midway case where source language transcription is available at training time only. In this case, a single model is trained to decode source speech into target text in a single pass. Experimental results show that it is possible to train compact and efficient end-to-end speech translation models in this setup. We also distribute the corpus and hope that our speech translation baseline on this corpus will be challenged in the future.
Silica gel assisted reductive cyclization of 2‐nitro‐β‐piperidinostyrenes, derived from 2‐nitrotoluenes, to indoles (1987)

Abstract An efficient modification of the Leimgruber‐Batcho method of indole synthesis has been devised that facilitates the synthesis of a variety of 2,3‐unsubstituted indoles containing halogen, methoxy and benzyloxy groups, from 2‐nitrotoluenes, in high yields. The modified method involves the condensation of 2‐nitrotoluenes with tripiperidinomethane followed by the reductive cyclization of the intermediate 2‐nitro‐β‐piperidinostyrenes with iron and acetic acid in refluxing toluene in the presence of silica gel (column chromatography grade, 60–200 mesh).
Incorporation of Multiple Sequential Pseudothymidines by DNA Polymerases and Their Impact on DNA Duplex Structure (2008)

Thermal denaturation and circular dichroism studies suggested that multiple (up to 12), sequential pseudothymidines, a representative C-glycoside, do not perturb the structure of a representative DNA duplex. Further, various Family A and B DNA polymerases were found to extend a primer by incorporating four sequential pseudothymidine triphosphates, and then continue the extension to generate full-length product. Detailed studies showed that Taq polymerase incorporated up to five sequential C-glycosides, but not more. These results constrain architectures for sequencing, quantitating, and analyzing DNA analogs that exploit C-glycosides, and define better the challenge of creating a synthetic biology using these with natural polymerases.
Cucumisin, a serine protease from melon fruits, shares structural homology with subtilisin and is generated from a large precursor (1994)

Cucumisin is a thermostable alkaline serine protease that is found in the juice of melon fruits (Cucumis melo L.). We have determined the complete nucleotide sequence of a cucumisin cDNA (2,552 nucleotides) and deduced the corresponding amino acid sequence. The open reading frame of the cDNA consists of 731 codons and encodes a large precursor (molecular weight, 78,815) relative to the observed size of mature native cucumisin (67 kDa). Sequence comparisons reveal that cucumisin has several features in common with the microbial proteases of the subtilisin family. The highly conserved sequences to the proximal regions of the catalytic triad amino acids Asp, His, and Ser, together with the substrate binding site in subtilisin, can be found within the deduced amino acid sequence of the protease domain of the cucumisin precursor. Cucumisin is the first known plant protease with such characteristics. Examination of the primary structure of cucumisin revealed that it is synthesized as a precursor, consisting of four functional domains: a possible signal peptide (22 amino acid residues), an NH2-terminal pro-sequence (88 residues), a 54-kDa protease domain (505 residues), which is the active enzyme domain of the 67-kDa native cucumisin, and a 14-kDa COOH-terminal polypeptide (116 residues), which arises by limited autolysis of the 67-kDa native cucumisin. This structure of cucumisin suggests that it is probably synthesized as an inactive precursor.
Intravesical immunotherapy in nonmuscle invasive bladder cancer (2015)

The beneficial effect of BCG is well documented and established. To reduce the tumor specific mortality, it is essential to follow guideline-based treatment. In patients with BCG-failure, there are new promising alternatives other than BCG but BCG remains the gold standard at this stage.
N-(2-Methyl-2-nitropropyl) and N-Nitroso Derivatives of Some Diamines (1995)

Preparation of ten new derivatives of 1,6-hexanediamine and 1,4-bis(4-aminophenoxy)butane with different combination of N -nitroso and/or N -(2-methyl-2-nitropropyl) groups is presented. The title compounds are potential improvers of vulcanized rubber dynamic properties.
Effects of collagen fiber orientation on the response of biologically derived soft tissue biomaterials to cyclic loading (2006)

In the present study, the effects of initial collagen fiber orientation on the medium-term (up to 50 x 10(6) cycles) fatigue response of heart valve soft tissue biomaterials was investigated. Glutaraldehyde treated bovine pericardium (GLBP), preselected for uniform structure and collagen fiber orientation, was used as the representative heart valve biomaterial. Using specialized instrumentation, GLBP specimens were subjected to cyclic tensile loading to maximum stress levels of 500 +/- 50 kPa at a frequency of 22 Hz. Two sample groups were examined, one with the preferred collagen fiber direction parallel (PD) and perpendicular (XD) to the direction of applied strain. The primary findings indicated that GLBP fatigue response was highly sensitive to the direction of loading with respect to fiber orientation. Specifically, when loading perpendicular to the preferred collagen fiber orientation, fiber reorientation is the dominant mechanism. In contrast, when loaded parallel to the preferred fiber direction a reduction in both collagen fiber crimp and fiber reorientation occurred. Moreover, alterations in the degree and direction of mechanical anisotropy can be inducted by cyclic loading when specimens are loaded perpendicular to the preferred fiber direction. Fourier Transform Infrared Spectroscopy (FT-IR) results indicate that molecular-level damage to collagen occurs in both groups after only 20 x 10(6) cycles. Taken as a whole, the results of this study suggest that initial collagen orientation plays a critical role in bioprosthetic heart valve biomaterial fatigue response.
CHROMATOGRAPHIC SEPARATION AND ISOLATION OF METACHROMATIC THIAZINE DYES (1960)

1. The chromatographic behaviour of 22 closely related N-alkyl thionins in a number of solvent systems is described. 2. Details are given of the separation of commercial mixtures of the azures into their components and the application of this to the analysis of Romanowsky stains. 3. A table giving the R f equivalents and absorption maxima of the dyes is appended and the additive effect of alkyl substitution is discussed.
Maximum Horizontal Stress and Wellbore Stability While Drilling: Modeling and Case Study (2010)

Abstract Maximum horizontal stress is a critical parameter used in drilling optimization and wellbore stability modeling. Current maximum horizontal stress prediction from wellbore breakout was based on the maximum tangential stress on the wellbore wall to be equal to the rock uniaxial compressive strength. We assume that the vertical, minimum and maximum horizontal stresses define a specific relationship when the stresses in the formation are in equilibrium. Based on a generalized Hooke's law with coupling the equilibrium of stresses and pore pressure, the maximum horizontal stress can be solved using this relationship. This new technique can reduce the uncertainty of in-situ stress prediction by narrowing the area of the conventional polygon of the in-situ stresses. We also propose a new method of the maximum horizontal stress determination from analyses of drilling-induced near-wellbore stresses and breakouts. The near-wellbore stresses are obtained from poroelastic equations. By using Mohr-Coulomb failure criterion, the maximum horizontal stress magnitude can be derived from these equations and from analysis of wellbore breakout obtained from borehole caliper logs. The new technique is compared to the existing methods in an example from measured borehole failures in a case study. These comparisons demonstrate that new technique provides a much better result than the current available methods, because the wellbore failure is related with all of the near-wellbore stresses. A case study has been conducted in a GOM oil field to predict pre-drill wellbore stability, where borehole instability was the main cause of borehole trouble time in offset wells. Using the proposed in-situ stress method, an improved borehole stability model was built to predict the pre-drill mud weight window. Applying this prediction, wellbore failures and drilling risks were greatly reduced.
Methylation Status of CpG Islands Flanking a cAMP Response Element Motif on the Protein Phosphatase 2Acα Promoter Determines CREB Binding and Activity (2009)

Protein phosphatase 2A (PP2A) is a major serine/threonine protein phosphatase in eukaryotic cells and is involved in many essential aspects of cell function. The catalytic subunit of the enzyme (PP2Ac), a part of the core enzyme, has two isoforms, alpha (PP2Ac alpha) and beta (PP2Ac beta), of which PP2Ac alpha is the major form expressed in vivo. Deregulation of PP2A expression has been linked to several diseases, but the mechanisms that control the expression of this enzyme are still unclear. We conducted experiments to decipher molecular mechanisms involved in the regulation of the PP2Ac alpha promoter in human primary T cells. After preparing serially truncated PP2Ac alpha promoter luciferase constructs, we found that the region stretching around 240 bases upstream from the translation initiation site was of functional significance and included a cAMP response element motif flanked by three GC boxes. Shift assays revealed that CREB/phosphorylated CREB and stable protein 1 could bind to the region. Furthermore, we demonstrated that methylation of deoxycytosine in the CpG islands limited binding of phosphorylated CREB and the activity of the PP2Ac alpha promoter. In contrast, the binding of stable protein 1 to a GC box within the core promoter region was not affected by DNA methylation. Primary T cells treated with 5-azacitidine, a DNA methyltransferase inhibitor, showed increased expression of PP2Ac alpha mRNA. We propose that conditions associated with hypomethylation of CpG islands, such as drug-induced lupus, permit increased PP2Ac expression.