gebhart/patrepeval huggingface dataset:
Reversal of the Orientation of an Integral Protein of the Mitochondrial Outer Membrane (1992)

The NH2-terminus of the signal-anchor sequence of an integral, bitopic protein of the outer mitochondrial membrane was extended both in amino acid length (from 11 to 38 amino acids) and net charge (from +4 to +8)--changes that confer on the NH2-terminus characteristics of a strong matrix-targeting signal. The protein was inserted into the outer membrane but in an inverted orientation (Ncyto-Cin). These findings suggest that, in common with other membrane systems, the orientation of a protein in the outer mitochondrial membrane can be determined by a signal that causes retention of the NH2-terminus on the cytosolic side of the membrane.
On-Chip Reflectivity-Tunable Single Wavelength Reflector (2015)

We propose an on-chip reflectivity-tunable single wavelength reflector, based on a coupling-modulation microring with an integrated reflective element. Reflectivity ranging from 0 to 1 can be obtained by tuning the coupling coefficient. With the reflective element parameters chosen carefully, the operation bandwidth of the reflector can be designed to accommodate the input signal with different bit rates and modulation formats. Combining the proposed reflector with delay-tunable photonic elements, an on-chip reconfigurable optical correlator is proposed. This on-chip optical correlator demonstrates reconfigurability, scalability, and size reduction, and thus, it is promising for on-chip optical packet switching networks.
Nd:YAG end-pumped by semiconductor laser arrays (1985)

Nd:YAG pumped by semiconductor lasers has shown great promise in achieving reliable and highly efficient operation. In this paper a Nd:YAG laser pumped by semiconductor arrays utilizing a tightly focused end pump geometry is described. Theoretical analyses1 have shown that in this arrangement over halt of the pump light could be converted into laser light. Thus, by combining several laser diodes, laser sources having greater power, spectral purity, peak-to-average power capability, beam quality, and lower beam divergence than laser diodes are realizable while sacrificing very little in terms of efficiency and compactness.
Chromatographic separation of the enantiomers of N-acylated heterocyclic amines (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChromatographic separation of the enantiomers of N-acylated heterocyclic aminesWilliam H. Pirkle, Christopher J. Welch, George S. Mahler, A. I. Meyers, Lelia M. Fuentes, and Michael BoesCite this: J. Org. Chem. 1984, 49, 13, 2504–2506Publication Date (Print):June 1, 1984Publication History Published online1 May 2002Published inissue 1 June 1984https://pubs.acs.org/doi/10.1021/jo00187a043https://doi.org/10.1021/jo00187a043research-articleACS PublicationsRequest reuse permissionsArticle Views268Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ω‐3 Fatty Acids–Supplemented Parenteral Nutrition Decreases Hyperinflammatory Response and Attenuates Systemic Disease Sequelae in Severe Acute Pancreatitis: A Randomized and Controlled Study (2008)

PN supplemented with omega-3 FAs diminishes the hyperinflammatory response by the EPA increase and the proinflammatory cytokine decrease in severe acute pancreatitis. This, together with improved respiratory function and shortened CRRT time, suggests that the systemic response to pancreatic and organ injury is attenuated.
Backprojection-based imaging geometric parameter estimation (2008)

In SPECT (single photon emission computed tomography) and X-ray CT, point sources are commonly used to acquire data for imaging parameter estimation. The parameters are estimated by fitting the point source projection data to a mathematical model of the imaging system. This paper introduces two backprojection-based parameter estimation methods. In the first method a point source is attached to the object; the second method is data-based without using a point source at all.
Liquid crystal cells based on photovoltaic substrates (2016)

Liquid crystal cells with LiNbO3:Fe crystals as substrates, are described. The photovoltaic field generated by the substrates is able to reorient the liquid crystal director thus giving rise to a phase shift on the light propagating through the cell, as in liquid crystal light valves. The process does not require the application of an external electric field, thus being potentially useful for applications requiring a high degree of compactness. An efficient optical switch with a high transmission contrast, based on the described optically-induced electric field, is also proposed.
Electronically tunable acousto-optic filter (1969)

The paper reports experimental results on a new type of electronically tunable optical filter (1). The filter makes use of collinear acoustic-optic diffraction in an optically anisotropic media. By changing the driving acoustic frequency, the band of optical frequencies which the filter will pass may be changed. A LiNbO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> acoustic-optic filter with a pass band approximately 2 Å wide, which is tunable from 750 Å to 5500 Å by changing the acoustic frequency from 750 Mc to 1050 Mc, has been demonstrated. Peak transmission at band center is about 30 percent and average rejection outside the pass band is about 50 db.
p<sup>+</sup>–n diodes with a lateral porous layer as gas sensors (2007)

Abstract In this work an integrated p + –n diode, diffused on a crystalline substrate and provided with a thin adsorbing porous layer, is proposed as gas sensor. The sensor can be easily integrated by using an industrial CMOS process due to the fact that the porous film formation is the last process step. The sensitivity to isopropanol vapors has been investigated by measuring both the forward and reverse current of the diode as a function of the vapor concentration. The current variations, up to two orders of magnitude, could be explained by assuming that the adsorption of molecules in the porous layer and their interaction with localized states modify the band structure of the crystalline diode at the interface with the porous silicon, and in turn its current. Another sensor feature is that the value of the reverse current variation, induced by isopropanol vapors, depends on the voltage, so that the sensitivity can be settled by simply changing the reverse voltage itself. The fabrication process, the static and dynamic behavior of the sensor are presented and discussed. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
DNA-triplex stabilizing properties of 8-aminoguanine (2000)

A DNA-triplex stabilizing purine (8-aminoguanine) is designed based on molecular modeling and synthesized. The substitution of guanine by 8-aminoguanine largely stabilizes the triplex both at neutral and acidic pH, as suggested by molecular dynamics and thermodynamic integration calculations, and demonstrated by melting experiments. NMR experiments confirm the triplex-stabilizing properties of 8-aminoguanine and demonstrate that few changes are found in the structure of the triplex due to the presence of this modified base.
Dissociation constants of hydroxy coumarins (1958)

B. N. Mattoo, Trans. Faraday Soc., 1958, 54, 19 DOI: 10.1039/TF9585400019
Efficient Surfel-Based SLAM using 3D Laser Range Data in Urban Environments (2018)

Accurate and reliable localization and mapping is a fundamental building block for most autonomous robots.For this purpose, we propose a novel, dense approach to laserbased mapping that operates on three-dimensional point clouds obtained from rotating laser sensors.We construct a surfel-based map and estimate the changes in the robot's pose by exploiting the projective data association between the current scan and a rendered model view from that surfel map.For detection and verification of a loop closure, we leverage the map representation to compose a virtual view of the map before a potential loop closure, which enables a more robust detection even with low overlap between the scan and the already mapped areas.Our approach is efficient and enables real-time capable registration.At the same time, it is able to detect loop closures and to perform map updates in an online fashion.Our experiments show that we are able to estimate globally consistent maps in large scale environments solely based on point cloud data.
A new in-built device for one-point stepless prosthetic alignment (1988)

The authors have developed a new in-built device for alignment of below-knee prostheses. The device allows one-point, stepless adjustment of angle and slide, independently of each other and also after completed prosthetic manufacture. Principally, the device consists of a half-sphere for angle adjustment and a plate for both slide adjustment and socket application. If the socket has to be exchanged, the whole device can be re-used, apart from the plate, which forms part of the socket bottom. The device is light, compact, cosmetically easy to cover and cheap. The design incorporates a combination of the most important facilities for alignment as well as for exchange of socket, and by its simplicity seems to offer major advantages over other designs.
Measurement of deposition rate in matrix spectroscopy with a small laser (1973)

A set-up is reported for measurement of the deposition rate of transparent matrix materials typically used in matrix isolation spectroscopy. Its main features consist in measurement of intensity of interference fringes produced by the growing matrix layer on the light of a small laser by a simple power meter. A typical example for an Ar matrix is shown.
Parametric Amplification of Spin Waves Using Acoustic Waves (2015)

Spin waves are a promising prospect for the development of microwave information processing devices. A major obstacle in the study of spin waves is the large intrinsic spin-wave damping in most known magnetic materials. Viable spin-wave amplification techniques are thus required to make further progress in the development of spin-wave-based logic devices. In this paper, we investigate a novel technique of parametric modulation of spin waves using bulk acoustic waves. Although it is not a conclusive proof of parametric amplification, we show that bulk acoustic waves at twice the frequency of the propagating spin waves on coupling into an yttrium iron garnet film can modulate the amplitude of the spin wave. This paper provides insight into magnon-phonon interactions, and suggests a new mechanism to compensate for inherent losses in spin-wave propagation in spin-wave-based logic devices.
Novel low power Class-B output buffer (2002)

This paper describes the design of a Class-B output buffer for driving large capacitance load in flat panel display. Due to the large number of output buffers on a column driver chip, the quiescent current of the output buffer must be reduced. A comparator which produces full-swing output is used in the negative feedback path to eliminate quiescent current in the last stage. The proposed circuit was implemented in a 0.8 /spl mu/m CMOS process. The measured maximum static current is 54 /spl mu/A. With 5 V supply voltage and 600 pF load, the tracking error voltage is less than /spl plusmn/8 mV and the output swing is from 0.5 V to 5 V. The settling time for 4 V swing to 0.2% is 8 /spl mu/s, which is more than adequate for driving 1204*1280 pixels LCD panel with 86 Hz frame rate.
Characterization of <i>MSM1</i>, the structural gene for yeast mitochondrial methionyl‐tRNA synthetase (1989)

Respiratory-deficient mutants of Saccharomyces cerevisiae assigned to pet complementation group G72 are impaired in mitochondrial protein synthesis. The loss of this activity has been correlated with the inability of the mutants to acylate the two methionyl-tRNAs of yeast mitochondria. A nuclear gene (MSM1) capable of complementing the respiratory deficiency has been cloned by transformation of the G72 mutant C122/U3 with a yeast genomic library. In situ disruption of the MSM1 gene in a wild-type haploid strain of yeast induces a respiratory-deficient phenotype but does not affect the ability of the mutant to grow on fermentable substrates indicating that the product of MSM1 functions only in mitochondrial protein synthesis. Mitochondrial extracts prepared from the mutant with the disrupted copy of MSM1 were found to be defective in acylation of the two mitochondrial methionyl-tRNAs thereby confirming the identity of MSM1 as the structural gene for the mitochondrial methionyl-tRNA synthetase. The sequence of the protein encoded by MSM1 is similar to the Escherichia coli and yeast cytoplasmic methionyl-tRNA synthetases. Based on the primary-sequence similarities of the three proteins, the mitochondrial enzyme appears to be more related to the bacterial than to the yeast cytoplasmic methionyl-tRNA synthetase.
Innovations and Challenges in Renal Cell Carcinoma: Summary Statement from the Second Cambridge Conference (2007)

Innovations and Challenges in Renal Cancer, chaired by Michael B. Atkins, was held April 28 to 29, 2006 in Cambridge, Massachusetts. The conference brought together leading experts in the fields of cancer research, medical oncology, urology, immunology, radiology, and immunotherapy, with the goal of advancing the field of renal cancer treatment by critiquing new data from ongoing clinical trials and stimulating communication among those involved in basic and clinical research. The conference proceedings published in this educational supplement to Clinical Cancer Research are intended to provide timely information and recommendations on important aspects of renal cancer genetics and biology and advances in prognostic classification and treatment.
Biohydrogenation of Unsaturated Fatty Acids (1971)

The name of this enzyme was originally designated as linoleate A1'%s,A1%"ans-isomerase(2, 4).However, since
SU-8 thick photoresist processing as a functional material for MEMS applications (2002)

The use of SU-8 high aspect ratio, thick, photoresist as a functional material for MEMS applications is described in this paper. SU-8 processing is developed to implement low-stress SU-8 structures as permanent and functional material incorporated with silicon-on-insulator technologies. Silicon micromachined cantilevers were fabricated with SU-8 structures on the cantilevers as added masses. Separation of material function can be achieved in this way. Silicon provides excellent mechanical properties, while SU-8 is used as extra mass to adjust the mechanical behaviour. The resonance behaviour of the cantilever structure with SU-8 is characterized through measurement, simulation and calculation, and the strength of the SU-8 material for this purpose is evaluated. The results show that SU-8 is well suited as a permanent material in mechanically active MEMS devices, and several applications are suggested. 3D MEMS architectures can also be achieved in this manner.
Research on the EHB system control method base on identification of drivers' braking intentions (2009)

The control strategy of the EHB (electronic hydraulic braking) system on hardware-in-loop simulation test-platform is presented based on driver's command via brake pedal sensor. Firstly, a fuzzy logic control method is used to identify the drivers' breaking intention. Then, PID control methods are used to control the switching of the solenoid valve to regulate the wheel brake cylinder pressure. After that, emergency braking procedure simulation is made to test the effectiveness of this control strategy. The proposed control strategy shows very good performance in an emergency braking event which can shorten the response time to improve driving safety.
Cross-modality image synthesis from unpaired data using CycleGAN: Effects of gradient consistency loss and training data size (2018)

CT is commonly used in orthopedic procedures. MRI is used along with CT to identify muscle structures and diagnose osteonecrosis due to its superior soft tissue contrast. However, MRI has poor contrast for bone structures. Clearly, it would be helpful if a corresponding CT were available, as bone boundaries are more clearly seen and CT has standardized (i.e., Hounsfield) units. Therefore, we aim at MR-to-CT synthesis. The CycleGAN was successfully applied to unpaired CT and MR images of the head, these images do not have as much variation of intensity pairs as do images in the pelvic region due to the presence of joints and muscles. In this paper, we extended the CycleGAN approach by adding the gradient consistency loss to improve the accuracy at the boundaries. We conducted two experiments. To evaluate image synthesis, we investigated dependency of image synthesis accuracy on 1) the number of training data and 2) the gradient consistency loss. To demonstrate the applicability of our method, we also investigated a segmentation accuracy on synthesized images.
Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients (2019)

There is increasing evidence indicating a role for Fusobacterium nucleatum (F. nucleatum) in colorectal cancer (CRC) development and prognosis. This study evaluated F. nucleatum as a prognostic biomarker, by assessing its association with post-diagnosis survival from CRC. From September 2008 to April 2012 CRC patients (n = 190) were recruited from three hospitals within the Czech Republic. F. nucleatum DNA copies were measured in adjacent non-malignant and colorectal tumor tissues using quantitative real-time PCR. Cox Proportional Hazards (HR) models were applied to evaluate the association between F. nucleatum DNA and overall survival, adjusting for key confounders. Risk prediction modeling was conducted to evaluate the ability to predict survival based on F. nucleatum status. High, compared with low, levels of F. nucleatum in colorectal tumor tissues were associated with poorer overall survival (adjusted HR 1.68, 95% CI 1.02-2.77), which was slightly attenuated after additional adjustment for microsatellite instability status. However, inclusion of F. nucleatum in risk prediction models did not improve the ability to identify patients who died beyond known prognostic factors such as disease pathology staging. Although the increased presence of F. nucleatum was associated with poorer prognosis in CRC patients, this may have limited clinical relevance as a prognostic biomarker.
Strength and Static Fatigue of Abraded Glass Under Controlled Ambient Conditions: IV, Effect of Surrounding Medium (1961)

The strength and static fatigue behavior of abraded glass specimens tested in various surrounding media have been studied. The test media included distilled water, nitrogen atmospheres of varying humidity, methyl and isopropyl alcohol and mixtures of these with distilled water, and various acidic and basic solutions. For intermediate durations of load the strength values in atmospheres of 0.5 and 43% relative humidity were 45 and 20% greater, respectively, than in distilled water. The value of t 0.5 , the characteristic duration for static fatigue, under these three test conditions was 3500, 200, and 8 seconds, respectively, for the particular grit‐blast abrasion studied, indicating that liquid water is the most effective agent for promoting a high rate of static fatigue and very dry air with a small concentration of water vapor is least effective. In reagent‐grade methyl or isopropyl alcohol (0.01 to 0.05% H 2 O) the strength at an intermediate load duration of 10 seconds was about 40% greater than in distilled water and the slope of the static fatigue curve differed somewhat from that obtained for tests in water. With the addition of water to the alcohol solutions the fatigue curve became parallel to that for water, and as the water content was increased, the curves shifted toward the water curve. For tests in acidic and basic solutions the strength at an intermediate load duration was independent of pH over the range pH 1 to 13. For more acidic solutions the strength was slightly less and for more basic solutions slightly greater than in this range. The results are discussed in terms of possible mechanisms for static fatigue. It is concluded that the static fatigue of abraded glass results from changes in the shape or size of surface abrasion cracks under the combined action of stress and the surrounding medium. In general, water or water vapor is the primary agent in promoting fatigue, and, unlike the usual chemical attack, the interaction appears to involve primarily the neutral water molecule and the SiO 2 network of the glass. The presence of other ions or molecules is relatively unimportant except as it may serve to reduce the concentration of water and its availability to the tip of the abrasion crack.
Actin enhances the haemolytic activity of Escherichia coli (1998)

Actin is a major cytoskeletal protein of mammalian muscle and non-muscle cells. Exposure of cells to soluble factors that damage cell membranes results in the release of actin into the extracellular spaces. The alpha-haemolysin (HlyA) of Escherichia coli is the prototype RTX (repeat in toxin) toxin and is thought to be important in virulence because of its ability to lyse cells by formation of pores in the cell membrane. These studies were conducted to determine if actin influences growth and haemolytic activity of E. coli. Growth of E. coli in the presence of actin resulted in culture supernatant haemolytic activity that was 2.4-, 2.7- and 3.3-fold greater than that of E. coli grown in medium containing BSA, non-supplemented medium, or medium containing heat-denatured actin, respectively. The enhanced haemolytic activity occurred only when actin was present during the growth phase and there was no effect when actin was added to culture supernatants containing haemolysin. The increased haemolytic activity by actin was concentration-dependent, detectable in early-exponential-phase growth, and associated with increased concentrations of secreted HlyA by Western blotting. Actin induced a 2.9-fold increase in alkaline phosphatase activity in E. coli CC118 with a TnphoA insertion in the hlyB determinant of the recombinant haemolysin plasmid pWAM04. These results indicate that extracellular actin enhances haemolysin production by E. coli and may have implications in the pathogenesis of E. coli infections.