gebhart/patrepeval huggingface dataset:
Altered <i>Tau</i> and Neurofilament Proteins in Neuro‐Degenerative Diseases: Diagnostic Implications for Alzheimer's Disease and Lewy Body Dementias (1993)

The neuronal cytoskeleton is one of the most profoundly altered organelles in late life neuro-degenerative disorders that are characterized by progressive impairments in cognitive abilities. The elucidation of the protein building blocks of these organelles as well as advances in understanding how these proteins become altered in Alzheimer's disease (AD) and other less common dementing illnesses, i.e., diffuse Lewy body disease (DLBD) or the Lewy body variant of AD (LBVAD), will provide insights into the molecular basis of these disorders. Within, we review evidence that normal adult human tau is abnormally phosphorylated and converted into the subunits of AD paired helical filaments (PHFs), and that Lewy bodies (LBs) represent accumulation of altered neurofilament (NF) triplet subunits. Although the precise biological consequences of PHF and LB formation in neurons is unknown, growing evidence suggests that the formation of PHFs and LBs from normal neuronal cytoskeletal proteins could have deleterious effects on neuronal function and survival. Finally, insights into the composition of PHFs and LBs could lead to the development of novel strategies for the timely and accurate diagnosis of AD, DLBD and the LBVAD.
Oligo(siloxane) rings and cages possessing nickel‐containing liquid crystal side chains (1996)

A liquid‐crystalline coordination compound immobilized on an oligomeric superstructure free from cross‐linking (see Figure) is reported for the first time. A highly versatile synthetic methodology is described that allows unsymmetrical, mono‐functionalized, metal‐containing liquid‐crystalline coordination complexes to be prepared. Related materials may find uses as novel catalysts. magnified image
Metal reduction at point-of-use filtration (2016)

We explored the metal removal efficiency of Nylon 6,6 and HDPE (High Density Polyethylene) membrane based filters, in solvents of varying degree of polarity such as Cyclohexanone and 70:30 mixture of PGME (Propylene Glycol Monomethyl Ether) and PGMEA (Propylene Glycol Monomethyl Ether), In all the solvents tested, Nylon 6,6 membrane filtration was found to be significantly more effective in removing metals than HDPE membranes, regardless of their respective membrane pore sizes. Hydrophilic interaction chromatography (HILIC) mechanism was invoked to rationalize metal removal efficiency dependence on solvent hydrophobicity.
Integrating subnetworks characterized by measured data into moment-matching simulations (2002)

Moment-matching techniques have been proposed for efficient transient waveform estimation of interconnect networks used in modelling MCM's. In this paper, we introduce an approach for incorporating components characterized by measured data, within a moment matching simulation. The new method is applied using complex frequency hopping (CFH), a multipoint moment-matching technique which enables the characterization of the network up to the highest frequency of interest. It allows for the efficient analysis of large networks which include lossy, coupled transmission lines, nonlinear terminations and arbitrary components represented by simulated or measured data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Photo-responsive properties and heating-induced surface relief patterns from azobenzene-doped GeO_2/γ-glycidoxypropyltrimethoxysilane organic-inorganic hybrid films (2007)

GeO(2/ gamma-)glycidoxypropyltrimethoxysilane organic-inorganic hybrid optical waveguide films, which contain azobenzene small molecular groups, have been prepared by combining a low temperature sol-gel process with a spin-coating technique. The azobenzene in hybrid films can undergo trans-cis-trans photoisomerization efficiently by a photoirradiation with UV light. It is also found interestingly that surface relief patterns can be heat-induced on such azobenzene-containing small molecular hybrid films, but can be erased by further heating the hybrid film and no permanent damage of the hybrid film is observed. The refractive index, thickness, and morphologic properties of the hybrid films have also been investigated by a prism coupling technique and atomic force microscopy. These results indicate that the azodye-doped hybrid films are promising candidates for integrated optics and photonic applications, which allow directly integrating on the same chip waveguide device with the optical data storage and optical switching devices.
Differential detection of S100A8 in transitional cell carcinoma of the bladder by pair wise tissue proteomic and immunohistochemical analysis (2005)

The search for novel molecular markers of tumor invasion is vital if strategies are to become more effective in the diagnostic and prognostic management of transitional cell carcinoma of the bladder. Up to 50% of tumors detected at stage 1 (pT1) progress to a higher grade even after endoscopic surgical resection, and there are currently no protein markers of this aggressive, invasive phenotype. We have combined SELDI-TOF-MS, ClinProt magnetic bead enrichment, Nano-LC-ESI-ion trap tandem mass spectrometry and immunohistochemical analysis to the study of 12 invasive bladder cancer tissue biopsies paired with normal bladder tissue samples obtained from the same patients for the definition and identification of proteins up-regulated in the tumors. We report the inflammation-associated calcium binding protein S100A8 (MRP-8, calgranulin A) to be highly expressed in tumor cells in contrast to normal urothelium in 50% of the samples, as well as two unidentified protein markers at 5.75 and 6.89 kDa that were differentially detected in 9/12 and 10/12 tumor samples, respectively. These new markers, when fully characterized, may contribute to new target proteins for the prediction of aggressive, invasive bladder tumors.
Hybrid heat exchange for the compression capture of CO2 from recirculated flue gas (2004)

An approach proposed for removal of CO2 from flue gas cools and compresses a portion of a recirculated flue-gas stream, condensing its volatile materials for capture. Recirculating the flue gas concentrates SOx, H2O and CO2 while dramatically reducing N2 and NOx, enabling this approach, which uses readily available industrial components. A hybrid system of indirect and direct-contact heat exchange performs heat and mass transfer for pollutant removal and energy recovery. Computer modeling and experimentation combine to investigate the thermodynamics, heat and mass transfer, chemistry and engineering design of this integrated pollutant removal (IPR) system.
Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. (2000)

Potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of two novel PARP inhibitors, NU1025 (8-hydroxy-2-methylquinazolin-4-[3H]one, Ki = 48 nM) and NU1085 [2-(4-hydroxyphenyl)benzamidazole-4-carboxamide, Ki = 6 nM], in combination with temozolomide (TM) or topotecan (TP) have been studied in 12 human tumor cell lines (lung, colon, ovary, and breast cancer). Cells were treated with increasing concentrations of TM or TP +/- NU1025 (50, 200 microM) or NU1085 (10 microM) for 72 h. The potentiation of growth inhibition by NU1025 and NU1085 varied between the cell lines from 1.5- to 4-fold for TM and 1- to 5-fold for TP and was unaffected by p53 status. Clonogenic assays undertaken in two of the cell lines confirmed that the potentiation of growth inhibition reflected the potentiation of cytotoxicity. NU1025 (50 microM) was about as effective as 10 microM NU1085 at potentiating growth inhibition and cytotoxicity, consistent with the relative potencies of the two molecules as PARP inhibitors. Potentiation of cytotoxicity was obtained at concentrations of NU1025 and NU1085 that were not toxic per se; however, NU1085 alone was 3-fold more cytotoxic (LC50 values ranged from 83 to 94 microM) than NU1025 alone (LC50 > 900 microM). These data demonstrate that PARP inhibitors are effective resistance-modifying agents in human tumor cell lines and have provided a comprehensive assessment protocol for the selection of optimum combinations of anticancer drugs, PARP inhibitors, and cell lines for in vivo studies.
On LDPC codes over channels with memory (2006)

The problem of detection and decoding of low-density parity-check (LDPC) codes transmitted over channels with memory is addressed. A new general method to build a factor graph which takes into account both the code constraints and the channel behavior is proposed and the a posteriori probabilities of the information symbols, necessary to implement maximum a posteriori (MAP) symbol detection, are derived by using the sum-product algorithm. With respect to the case of a LDPC code transmitted on a memoryless channel, the derived factor graphs have additional factor nodes taking into account the channel behavior and not the code constraints. It is shown that the function associated to the generic factor node modeling the channel is related to the basic branch metric used in the Viterbi algorithm when MAP sequence detection is applied or in the BCJR algorithm implementing MAP symbol detection. This fact suggests that all the previously proposed solutions for those algorithms can be systematically extended to LDPC codes and graph-based detection. When the sum-product algorithm works on the derived factor graphs, the most demanding computation is in general that performed at factor nodes modeling the channel. In fact, the complexity of the computation at these factor nodes is in general exponential in a suitably defined channel memory parameter. In these cases, a technique for complexity reduction is illustrated. In some particular cases of practical relevance, the above mentioned complexity becomes linear in the channel memory. This does not happen in the same cases when detection is performed by using the Viterbi algorithm or the BCJR algorithm, suggesting that the use of factor graphs and the sum-product algorithm might be computationally more appealing. As an example of application of the described framework, the cases of noncoherent and flat fading channels are considered
Midline depressed skull fracture presenting with quadriplegia: A rare phenomenon (2017)

MDSF can present with quadriparesis/quadriplegia due to middle one-third SSS obstruction/thrombosis leading to bilateral motor cortical venous infarction. Such MDSFs may require emergent surgical elevation of the depressed bone fragment for restoration of the patency of the sinus.
Puntaje de calcio y severidad de la enfermedad coronaria (2011)

Introducción: La presencia de calcio en las coronarias es prácticamente patognomónica de aterosclerosis. En el año 1990, Agatston diseñó un método para cuantificar el calcio mediante la tomografía. El objetivo del presente trabajo fue determinar la presencia de asociación entre puntaje de calcio coronario y la severidad de la enfermedad coronaria. Método: Se incluyeron 276 pacientes (80 % del sexo masculino y edad media de 56 ± 10 años) con sospecha de cardiopatía isquémica a los que inicialmente se les realizó cuantificación del calcio coronario mediante una tomografía de 64 cortes y posteriormente coronariografía invasiva. Se consideró el grado de calcificación en normal si 0 UA; ligero de 1 - 100 UA; moderado de 101 - 400 UA y severo si mayor o igual que 401 UA. Se calculó el Chi Cuadrado y la correlación de Spearman para determinar el grado de asociación entre el puntaje de calcio coronario y la presencia de estenosis significativa. Resultados: El 92,4 % de los pacientes con puntaje de calcio 0 unidades Agatston, no tuvieron estenosis coronaria significativa, sin embargo, el 94,2 % con puntaje mayor o igual que 400 unidades Agatston, sí se les diagnosticó (p= 0,001 y correlación de Spearman 0,88). Conclusiones: Existe asociación entre el grado de calcificación coronaria con la presencia de estenosis significativa.
Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritis. (1977)

Significant differences in both specificity and avidity of anti-DNA antibodies were observed in the sera of groups of patients with active systemic lupus erythematosus glomerulonephritis, active systemic lupus erythematosus without nephritis, and in IgG eluates obtained by DNAase digestion of isolated glomeruli from glomerulonephritic kidneys. With methylated albumin-kieselguhr fractionated 3H-HeLa DNA as a source of native or single-strand DNA antigen in a modified Farr assay, an increased level of antibody to native DNA was associated with active systemic lupus erythematosus, particularly active nephritis. The avidity of antinative DNA estimated from plots of the reciprocals of bound and free antigen according to the Sips distribution formula was significanly lower in active glomerulonephritis sera than in sera from patients with active systemic lupus erythematosus without nephritis. However, antinative DNA of uniformly high avidity was found in the glomerular eluates. Avidity of single-strand DNA antibodies did not differ in the various patient groups. The data stronly supprot a major role for high avidity antinative-DNA in DNA/antiDNA immune complex-induced glomerular injury in systemic lupus erythematosus.
Extending the range of switchable-hydrophilicity solvents (2015)

A switchable-hydrophilicity solvent (SHS) is a solvent that in one state forms a biphasic mixture with water but can be reversibly switched to another state that is miscible with water. All of the amine SHSs that we have reported previously lie within a particular basicity and hydrophilicity range (9.5 < pKaH < 11 and 1.0 < log Kow < 2.5, respectively). We report an extension of this range by altering the pressure of CO2 as well as the water : SHS volume ratio used in the process. Increasing the pressure of CO2 and/or the water : amine volume ratio allows some amines with pKaH < 9.5 or log Kow > 2.5 to function as SHSs.
Oblivious RAM (2016)

Many companies choose the cloud as their data and IT infrastructure platform. The remote access of the data brings the issue of trust. Despite the use of strong encryption schemes, adversaries can still learn valuable information regarding encrypted data by observing the data access patterns. To that end, one can hide the access patterns, which may leak sensitive information, using Oblivious RAMs (ORAMs). Numerous works have proposed different ORAM constructions, but they have never been thoroughly compared against and tested on large databases. There are also no open source implementation of these schemes. These limitations make it difficult for researchers and practitioners to choose and adopt a suitable ORAM for their applications. To address this issue, we provide a thorough study over several practical ORAM constructions, and implement them under the same library. We perform extensive experiments to provide insights into their performance characteristics with respect to efficiency, scalability, and communication cost.
Oral Administration of Royal Jelly Facilitates mRNA Expression of Glial Cell Line-Derived Neurotrophic Factor and Neurofilament H in the Hippocampus of the Adult Mouse Brain (2005)

Royal jelly (RJ) is known to have a variety of biological activities toward various types of cells and tissues of animal models, but nothing is known about its effect on brain functions. Hence, we examined the effect of oral administration of RJ on the mRNA expression of various neurotrophic factors, their receptors, and neural cell markers in the mouse brain. Our results revealed that RJ selectively facilitates the mRNA expression of glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophic factor acting in the brain, and neurofilament H, a specific marker predominantly found in neuronal axons, in the adult mouse hippocampus. These observations suggest that RJ shows neurotrophic effects on the mature brain via stimulation of GDNF production, and that enhanced expression of neurofilament H mRNA is involved in events subsequently caused by GDNF. RJ may play neurotrophic and/or neuroprotective roles in the adult brain through GDNF.
The 1987 national electrical code requirements for cable (1986)

Abstract : The 1987 National Electrical Code has established four levels of fire-resistance for communications cables. The highest level is required for plenum cables; these cables are tested per the UL 910 tunnel test. The second highest level is required for riser cables, which must pass the UL riser test (UL 1666). These requirements for plenum and riser cables are not new. New in the 1987 Code is the third level requirement that general purpose cables (not plenum, not riser) must pass the vertical-tray flame test. This test is the least severe of the large scale fire tests. Communications cables that only pass the small scale vertical-wire (VW-1) test (lowest level) will be permitted as general wiring in residences, and in conduit in nonresidential buildings. Exposed lengths of up to 10 feet are also permitted in nonresidential buildings in nonconcealed spaces only. Non-fire-resistant outside plant telephone cable may not be run more than 50 feet beyond the building entrance. (Author)
Application of secondary structure prediction in antisense drug design targeting protein kinase C-alpha mRNA and QSAR analysis. (2000)

Computer aided design was helpful to obtain S-ODN with better in vitro effect than current positive drug. The degree of instability of secondary structural elements and delta G degree 37 were important factors for drug activity. Other important factors needed for further investigation.
The<i>LP2</i>leucine‐rich repeat receptor kinase gene promoter directs organ‐specific, light‐responsive expression in transgenic rice (2009)

Biotechnologists seeking to limit gene expression to nonseed tissues of genetically engineered cereal crops have only a few choices of well characterized organ-specific promoters. We have isolated and characterized the promoter of the rice Leaf Panicle 2 gene (LP2, Os02g40240). The LP2 gene encodes a leucine-rich repeat-receptor kinase-like protein that is strongly expressed in leaves and other photosynthetic tissues. Transgenic rice plants containing an LP2 promoter-GUS::GFP bifunctional reporter gene displayed an organ-specific pattern of expression. This expression corresponded to transcript levels observed on RNA blots of various rice organs and microarray gene expression data. The strongest beta-glucuronidase activity was observed in histochemically stained mesophyll cells, but other green tissues and leaf cell types including epidermal cells also exhibited expression. Low or undetectable levels of LP2 transcript and LP2-mediated reporter gene expression were observed in roots, mature seeds, and reproductive tissues. The LP2 promoter is highly responsive to light and only weak expression was detected in etiolated rice seedlings. The specificity and strength of the LP2 promoter suggests that this promoter will be a useful control element for green tissue-specific expression in rice and potentially other plants. Organ-specific promoters like LP2 will enable precise, localized expression of transgenes in biotechnology-derived crops and limit the potential of unintended impacts on plant physiology and the environment.
Indirect fluorometric detection of anions in thin-layer chromatography (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIndirect fluorometric detection of anions in thin-layer chromatographyYinfa. Ma and Edward S. YeungCite this: Anal. Chem. 1988, 60, 7, 722–724Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/ac00158a026https://doi.org/10.1021/ac00158a026research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New Dose Estimates from Chronic Tritium Exposures (1969)

Estimates of the radiation dose from assimilation of tritium oxide, the common form of environmental tritium, are based on the assumption that tritium remains in body water until excreted. Analyses of deer tissues, however, indicate that chronic exposure to tritium causes significant labeling of organic molecules. The degree of labeling was determined from tritium assays of seven tissues (heart, liver, kidney, spleen, brain, muscle, and fat) from 52 deer collected on the Savannah River Plant site. In most tissues, the tritium-to-hydrogen ratios in both body water and the water of combustion of dried tissues were the same. This incorporation of tritium in the organic component of deer tissue results in whole body doses 1.4 to 1.5 times higher than estimated if only tritium in body water is considered.
RF/microwave device fabrication in silicon-on-glass technology (2008)

This paper reviews recent developments in circuit and device implementations based on back-wafer contacted silicon-on-glass (SOG) substrate-transfer technology (STT). This technology has been specifically developed for the enhancement of silicon RF and microwave device and circuit performance. While metal transmission lines can be placed on the low-loss glass substrate, the resistive and capacitive parasitics of the silicon devices can also be minimized by a direct contacting of the parts of the devices that are usually connected via the bulk Si. Focus is placed here on the device level aspects of the SOG process, in particular high-quality varactors for high-linearity adaptive circuits and complementary bipolar device integration are treated in relationship to new developments in back-wafer contacting and the integration of AlN heatspreaders.
Efficient Receiver Scheme for LTE PUCCH (2012)

In 3rd. Generation Partnership Project (3GPP) Long Term Evolution (LTE) systems, physical uplink control channel (PUCCH) incorporate Reference Signals (RSs) for eNodeB to perform channel estimation. However the RSs in PUCCH formats 2a/2b are related to the transmitted 10th symbol in UE. As a result, the receivers can not have a priori knowledge about the transmitted RSs and perform channel estimation aided by all of the RSs directly. In this work, an efficient low complexity receiver is proposed for PUCCH formats 2a/2b. What's more, it is also practical for other PUCCH formats with all priori-known RSs. As will be shown in our simulation results, remarkable performance gains are obtained for all PUCCH formats.