gebhart/patrepeval huggingface dataset:
Effect of Heme Oxygenase-1 Overexpression in Two Models of Lung Inflammation (2003)

An increasing number of studies implicate heme oxygenase-1 (HO-1) in the regulation of inflammation. Although the mechanisms involved in this cytoprotection are largely unknown, HO-1 and its enzymatic products, carbon monoxide and bilirubin, downregulate the inflammatory response by either attenuating the expression of adhesion molecules and thus inhibiting leukocyte recruitment or by repressing the induction of cytokines and chemokines. In the present study we used genetically engineered mice that express high levels of a human cDNA HO-1 transgene in lung epithelium to assess the effect of HO-1 on lung inflammation. Two separate models of inflammation were studied: hypoxic exposure and lipopolysaccharide (LPS) challenge. We found that both mRNA and protein levels of specific cytokines and chemokines were significantly elevated in response to hypoxia in the lungs of wild-type mice after 2 and 5 days of exposure but significantly suppressed in the hypoxic lungs of transgenic mice, suggesting that inhibition of these cytokines was caused by overexpression of HO-1. However, LPS treatment resulted in a very pronounced increase in mRNA levels of several cytokines in both wild-type and transgenic mice. Despite the high mRNA levels, significantly lower cytokine protein levels were detected in the bronchoalveolar lavage of HO-1 overexpressing mice compared with wild type, indicating that HO-1 leads to repression of cytokines in the airway. These results demonstrate that HO-1 activity operates through distinct molecular mechanisms to confer cytoprotection in the hypoxic and the LPS models of inflammation.
A Review of Active Learning and Co-Training in Text Classification (2005)

Ever increasing volumes of data in electronic format are being produced and stored, due mainly to the relatively inexpensive cost of storage and emerging techniques for extracting useful information from such data. A large corpus of data, in itself does not offer a lot of value but if it were categorised into relevant,
Automating Developers' Responses to App Reviews (2018)

App reviews are important as they contain valuable information for improving the quality of such software systems. To this end, most users providing app reviews expect a response; to the extent that prior research has shown that when developers respond to app reviews these responses improve app ratings and users' satisfaction. However, unfortunately, user reviews largely go unanswered for most apps due to the high prevalence of reviews. This challenge may be addressed by creating a system that automatically generates responses having learned from the responses already posted by developers for a given app. These generated responses may then be modified by developers if required. This work presents a system that recommends socially-acceptable responses based on principles adopted from three domains: information retrieval, social norms and userinterface design. We then evaluate the newly developed system against Google Play's de facto review response system, which requires developers to write responses manually. The evaluation of the two systems involved measuring participants' feedback on three aspects – usability, cognitive load and performance. The goal of the evaluation was to investigate whether users prefer the new system over the existing system. Our outcomes show that there were statistically significant differences between the two systems on all three aspects evaluated, with users preferring the newly proposed system over Google Play's response system. In particular, the proposed system has the potential to reduce the overall workload of developers considerably.
Analysis on transcranial doppler ultrasound to intracranial blood flow of diabetic patients (2012)

Objective To study and analyze the diagnostic value of transcranial doppler ultrasound in the detection of diabetes and cerebrovascular early lesions.Methods Type Ⅱ diabetic patients in our hospital from January 2010 to February 2012 were selected as the experimental group,other 53 cases of the control group at the same period in our hospital were chosen as control group,patients in both groups all received transcranial doppler ultrasound test,the results were compared and analyzed.Results The diabetes group:Arterial systolic velocity (101.02 ± 10.24) cm/s,mean flow velocity (68.62 ± 5.99) cm/s,diastolic velocity (42.64 ± 4.88) cm/s,pulsatility index (4.14 ± 1.03) cm/s,and eddy current percentage was high(13.21％),compared with the control group,showing significant difference,P＜0.05.Conclusion Use of transcranial doppler ultrasound for intracranial blood flow detection in diabetic patients has higher inspection value,and contribute to the early detection for patients with cerebrovascular disease.

Key words: 
Transcranial Doppler ultrasound;  Diabetes;  Cerebrovascular disease
Impaired Fertility and Spermiogenetic Disorders with Loss of Cell Adhesion in Male Mice Expressing an Interfering Rap1 Mutant (2007)

The guanosine trisphosphatase Rap1 serves as a critical player in signal transduction, somatic cell proliferation and differentiation, and cell-cell adhesion by acting through distinct mechanisms. During mouse spermiogenesis, Rap1 is activated and forms a signaling complex with its effector, the serine-threonine kinase B-Raf. To investigate the functional role of Rap1 in male germ cell differentiation, we generated transgenic mice expressing an inactive Rap1 mutant selectively in differentiating spermatids. This expression resulted in a derailment of spermiogenesis due to an anomalous release of immature round spermatids from the seminiferous epithelium within the tubule lumen and in low sperm counts. These spermiogenetic disorders correlated with impaired fertility, with the transgenic males being severely subfertile. Because mutant testis exhibited perturbations in ectoplasmic specializations (ESs), a Sertoli-germ cell-specific adherens junction, we searched for expression of vascular endothelial cadherin (VE-cadherin), an adhesion molecule regulated by Rap1, in spermatogenic cells of wild-type and mutant mice. We found that germ cells express VE-cadherin with a timing strictly related to apical ES formation and function; immature, VE-cadherin-positive spermatids were, however, prematurely released in the transgenic testis. In conclusion, interfering with Rap1 function during spermiogenesis leads to reduced fertility by impairment of germ-Sertoli cell contacts; our transgenic mouse provides an in vivo model to study the regulation of ES dynamics.
Membrane transfer of alpha-tocopherol. Influence of soluble alpha-tocopherol-binding factors from the liver, lung, heart, and brain of the rat. (1981)

The pH of liver supernatant was lowered from 7.4 to 5.1, which removed 23% of the soluble protein and 97% of the lipid-soluble phosphate, increased the total ..cap alpha..-tocopherol transfer activity 1.3-fold and the specific activity of the transfer rate 1.6-fold. This transfer activity was proportional to time up to 4 min and to protein concentrations up to 0.1 mg/ml. Fractionation of the pH 5.1-treated liver supernatant by gel filtration produced a single peak of ..cap alpha..-tocopherol transfer activity of M/sub r/ = 34,000 and a single peak of ..cap alpha..-tocopherol-binding activity which was coincident with the transfer activity. The transfer rate of this peak of activity was 316 pmol/min/mg of protein, a 9-fold purification over the original untreated supernatant. This ..cap alpha..-tocopherol transfer rate was reduced by 83 and 96% following pronase digestion or heat treatment (80/sup 0/C) of the soluble fraction, respectively, while trypsin digestion reduced the transfer rate only 18% and phospholipase C digestion had no effect. Untreated liver supernatant possessed the peak of binding activity of M/sub r/ = 34,000 and a high molecular weight binding fraction that eluted at the void volume. Heart and brain supernatants also possessed an ..cap alpha..-tocopherol-binding fraction that eluted atmore » the void volume, while lung supernatant lacked binding activity.« less
Beyond frontal faces: Improving Person Recognition using multiple cues (2015)

We explore the task of recognizing peoples' identities in photo albums in an unconstrained setting. To facilitate this, we introduce the new People In Photo Albums (PIPA) dataset, consisting of over 60000 instances of ∼2000 individuals collected from public Flickr photo albums. With only about half of the person images containing a frontal face, the recognition task is very challenging due to the large variations in pose, clothing, camera viewpoint, image resolution and illumination. We propose the Pose Invariant PErson Recognition (PIPER) method, which accumulates the cues of poselet-level person recognizers trained by deep convolutional networks to discount for the pose variations, combined with a face recognizer and a global recognizer. Experiments on three different settings confirm that in our unconstrained setup PIPER significantly improves on the performance of DeepFace, which is one of the best face recognizers as measured on the LFW dataset.
Attachment of epiphyseal cartilage cells and 17/28 rat osteosarcoma osteoblasts using mussel adhesive protein (1990)

These experiments show that mussel adhesive protein (MAP) enhances the attachment of osteoblasts and epiphyseal cartilage cells to plastic culture dishes and Vitallium. When MAP was applied to culture plate surfaces, there were two- to fivefold increases in the numbers of cells attaching compared to control surfaces (no MAP). Results were confirmed using two different cell attachment assay techniques. Osteoblast replication and culture on MAP is possible, suggesting that MAP is not toxic to cells. MAP also holds applied cells to surfaces as initially attached.
Benefits and Risks of the Hypericum Extract LI 160: Drug Monitoring Study with 3250 Patients (1994)

Effectiveness and acceptance of a 4-week treatment with hypericum extract LI 160 were investigated by 663 Private practitioners. The results of the 3250 patients (76% women and 24% men), were recorded using data sheets. The age of the patients ranged from 20 to 90 years (mean 51 years). Of the patients, 49% were mildly depressed, 46% intermediate, and 3% severely depressed. In about 30% of the patients, the situation normalized or improved during the therapy. Undesired drug effects were reported in 79 (2.4%) patients and 48 (1.5%) discontinued the therapy. Most frequently noted side effects were gastrointestinal irritations (0.6%), allergic reactions (0.5%), tiredness (0.4%), and restlessness (0.3%).
Data mining application in banking sector with clustering and classification methods (2015)

Because of the phenomenal rise in information, future forecasting systems about strategy development were needed in each area. Therefore, data mining techniques are used extensively in banking area such as many areas. In this study, conducted in banking sector, it was aimed to reduce the rate of risk in decision making to a minimum via analysis of existing personal loan customers and estimate potential customers' payment performances with k-means method is one of the clustering techniques and the decision trees method which is one of the models of classification in data mining. In the study, SPSS Clementine was used as a software of data mining and an application was done for evaluation of personal loan customers.
Antiasthmatic Activity of Luteolin-7-O-glucoside from Ailanthus altissima through the Downregulation of T Helper 2 Cytokine Expression and Inhibition of Prostaglandin E2 Production in an Ovalbumin-Induced Asthma Model (2009)

Previously, we reported that an ethanol extract of Ailanthus altissima has antiinflammatory activity in an ovalbumin (OVA)-sensitized murine asthmatic model. To determine the biological compounds from this plant, luteolin-7-O-glucoside (L7G) was isolated and its antiasthmatic activity was evaluated in an in vivo murine asthmatic model. L7G (10 to 100 mg/kg, per os (p.o.)) reduced the amount of eosinophil infiltration in bronchoalveolar lavage (BAL) fluid in a dose-dependent manner. In comparison, dexamethasone (5 mg/kg, p.o.), which was used as a positive control, also strongly inhibited the number of infiltrating eosinophils. L7G inhibited both the prostaglandin E(2) (PGE(2)) and serum immunoglobulin E level in BAL fluid in a dose-dependent manner. In addition, L7G inhibited the transcript profiles of interleukin (IL)-4, IL-5, and IL-13 mRNA expression levels in the murine asthma model, as determined using reverse transcription-polymerase chain reaction (RT-PCR). These results suggest that the antiasthmatic activity of L7G in OVA-induced lung inflammation may occur in part via the downregulation of T helper 2 cytokine transcripts as well as the inhibition of PGE(2) production.
Inhibition of angiotensin converting enzyme by phosphonic amides and phosphonic acids (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInhibition of angiotensin converting enzyme by phosphonic amides and phosphonic acidsRichard E. Galardy, Voula Kontoyiannidou-Ostrem, and Zbigniew P. KortylewiczCite this: Biochemistry 1983, 22, 8, 1990–1995Publication Date (Print):April 12, 1983Publication History Published online1 May 2002Published inissue 12 April 1983https://doi.org/10.1021/bi00277a039RIGHTS & PERMISSIONSArticle Views128Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (804 KB) Get e-Alerts Get e-Alerts
Detecting high-resolution polymorphisms in human coding loci by combining PCR and single-strand conformation polymorphism (SSCP) analysis. (1991)

A strategy is described that allows the development of polymorphic genetic markers to be characterized in individual genes. Segments of the 3' untranslated regions are amplified, and polymorphisms are detected by digestion with frequently cutting enzymes and with the detection of single-stranded conformation polymorphisms. This allows these genes, or DNA segments, to be placed on the linkage maps of human chromosomes. Polymorphisms in two genes have been identified using this approach. A HaeIII polymorphism was detected in the KIT proto-oncogene, physically assigned to chromosome 4q11-12. This polymorphism is linked to other chromosome 4p markers and is in linkage disequilibrium with a HindIII polymorphism previously described at this locus. We have also identified in the insulin-like growth factor1 receptor gene (IGF1R) a 2-bp deletion that is present at a frequency of .25 in the Caucasian population. Pedigree analysis with this insertion/deletion polymorphism placed the IGF1R gene at the end of the current linkage map of chromosome 15q, consistent with the physical assignment of 15q2526. Thus, polymorphisms in specific genes can be used to related the physical, genetic, and comparative maps of mammalian genomes and to simplify the testing of candidate genes for human diseases.
In-DRAM Data Initialization (2017)

Initializing memory with zero data is essential for safe memory management. However, initializing a large memory area slows down the system significantly. The most likely cause for initialization to slow down the system is the limited DRAM initialization method. At present, the only way to initialize DRAM area is to execute multiple WRITE commands. However, the WRITE command slows the initialization because of its small granularity and data bus occupancy. In this brief, we propose an efficient in-DRAM initialization method inspired by the internal structure and operation of DRAM. The proposed method, called row reset, uses a DRAM row buffer to zero out a single DRAM row at a time. Row Reset allows for parallel initialization on multiple DRAM banks without using off-chip data transfer, thus reducing initialization time by up to 63 times. Row reset is a practical approach, because it can be implemented with existing circuitry in DRAM without additional area overhead.
Beta-Adrenergic Agonist Stimulated Alveolar Fluid Clearance in Ex Vivo Human and Rat Lungs (1997)

Because beta-adrenergic agonist therapy may be useful clinically as a treatment to hasten the resolution of alveolar edema, this study was designed to examine the dose-dependent effects of beta-adrenergic agonist therapy on alveolar epithelial fluid clearance. The studies were done by instilling an isosmolar 5% albumin solution into the distal air spaces of both ex vivo rat and ex vivo human lungs that were inflated with 8 to 10 cm H2O with 100% oxygen and placed in a 37 degrees C humid incubator. Alveolar fluid clearance was measured by the progressive increase in concentration of protein over 1 or 4 h. Salmeterol, a new long-acting lipophilic agent, was more potent than terbutaline in stimulating alveolar fluid clearance from the ex vivo human lung. Therefore, salmeterol was used for these studies. The results indicated that: (1) basal, unstimulated alveolar fluid clearance in rat lungs was significantly faster than in human lungs (24 +/- 4% over 4 h in rat lungs compared with 11 +/- 2% over 4 h in human lungs, p < 0.05); (2) comparison of equivalent doses of beta-adrenergic stimulation indicated that stimulated clearance rates were also faster in rat lungs than in human lungs; (3) very low doses of salmeterol were effective in ex vivo rat lungs (10(-8) M); and (4) relatively low doses were effective in the ex vivo human lungs (10(-6) M) as a treatment for increasing alveolar fluid clearance. In summary, there are significant differences in the basal and stimulated rates of alveolar epithelial fluid clearance in rat and human lungs, although the ex vivo human studies may have underestimated maximal alveolar fluid clearance in the intact human lung. The human lung responds well to relatively low doses of beta-adrenergic agonist therapy, a finding with potentially important clinical implications for hastening the resolution of alveolar edema.
A 16Kb electrically erasable programmable ROM (1979)

RECENTLY, UV erasable programmable read only memories (EPROMs) have been greatly improved in both memory capacity and operating speed. Now, however, electrically erasable programmable read only memories (EEPROMs) have become the subject of intensive research, since they offer such advantages as on-board reprogrammability, no UV light and low package cost.
Metal–organic framework composites (2014)

Metal-organic frameworks (MOFs), also known as porous coordination polymers (PCPs), synthesized by assembling metal ions with organic ligands have recently emerged as a new class of crystalline porous materials. The amenability to design as well as fine-tunable and uniform pore structures makes them promising materials for a variety of applications. Controllable integration of MOFs and functional materials is leading to the creation of new multifunctional composites/hybrids, which exhibit new properties that are superior to those of the individual components through the collective behavior of the functional units. This is a rapidly developing interdisciplinary research area. This review provides an overview of the significant advances in the development of diverse MOF composites reported till now with special emphases on the synergistic effects and applications of the composites. The most widely used and successful strategies for composite synthesis are also presented.
Cytomegalovirus infection in renal transplant recipients diagnosed by nested-PCR (2001)

A prospective study of cytomegalovirus (CMV) infection was carried out on 34 renal transplant recipients managed at a General Hospital in Ribeirão Preto, SP, Brazil. Serologic tests showed that all patients were infected with CMV before renal transplantation. Two nested-PCR techniques with primers that recognize sequences of the glycoprotein B (gB) and H (gH) genes were used for CMV detection in blood and urine samples during the post-transplantation period. CMV was detected more frequently in blood samples than in urine samples (P<0.001). Thirty-three patients had CMV detected at least once in blood and/or urine samples. Seven of these patients (21.2%) were diagnosed as having symptomatic CMV infection and showed a worse clinical outcome, with a higher death rate (P = 0.03). No association between CMV viremia and graft rejection was observed. Nested-PCR was not useful to identify patients at risk for symptomatic CMV infection since only 21.2% of the patients with CMV infection were symptomatic.
L’essor de la faïence fine de Salins (Jura) (2003)

La faïencerie fine symbolise l’industrialisation de l’activité faïencière. Cependant, dans le cas français, cette évolution s’effectue en douceur dans des établissements de taille moyenne à l’image de l’exemple salinois. Salins est une petite ville située sur les premiers plateaux jurassiens. C’est un site de reculée drainé par un modeste cours d’eau appelé la Furieuse. Le relief karstique, avec ses galeries souterraines, a fait la fortune de Salins pendant le Moyen Âge, en facilitant le pomp...
Nonlinear inter-stage gain calibration for pipelined ADCs employing double dithering modes (2014)

A digital calibration scheme simultaneously correcting both linear and nonlinear errors of inter-stage amplifiers in pipelined ADCs is proposed. Two modes of dithering are employed for the linear gain measurement, and the difference between their results is used to indicate the nonlinear error. The additional analog complexity introduced by the proposed technique is no more than that in a classical signal dependent dithering scheme. Behavioral simulation shows that the proposed calibration scheme is able to correct both linear and nonlinear errors within 6 × 107 conversion steps, and improve SNDR from 47 dB to about 80 dB in a prototype 14-bit pipelined ADC having 5% full-scale gain compression in the 1st stage’s residue amplifier.
An electronic ballast with multi-step constant-power starting control for small-wattage metal halide lamps (2011)

This paper develops an electronic ballast with multi-step constant-power control for small-wattage metal halide (MH) lamps supplied from a dc power source. The ballast circuit consists of a buck-boost/fly-back conversion circuit and a half-bridge inverter with commonly used two capacitors. The starting scenario with multi-step constant-power, can limit the starting current at relatively low levels, and can run up the transient period faster as compared to that started by a constant current. A laboratory circuit is designed for 35 W MH lamps. Experimental results have demonstrated satisfactory performances. A circuit efficiency higher than 91% is achievable.
Designing bioinspired superoleophobic surfaces (2015)

Nature provides a range of functional surfaces, for example, water-repellent or superhydrophobic surfaces, most common among them the lotus leaf. While water-repellency is widespread in nature, oil-repellency is typically limited to surfaces submerged in water, such as fish scales. To achieve oleophobicity in air, inspiration must be taken from natural structures and chemistries that are not readily available in nature need to be introduced. Researchers usually turn to fluorinated materials to provide the low surface energy that, when combined with bioinspired surface topography, is the key to unlocking oil-repellency. This review presents the state-of-the-art in the fabrication of superoleophobic surfaces.