gebhart/patrepeval huggingface dataset:
Studies on thyroid hormone-binding proteins. I. The subunit structure of human thyroxine-binding globulin and its interaction with ligands. (1975)

Thyroxine-binding globulin was isolated from human plasma by ammonium sulfate fractionation, chromatographic separations on diethylaminoethyl-Sephadex, gel chromatography, and two different electrophoretic procedures. The highly purified was homogeneous when subjected to polyacrylamide gel electrophoresis, ultracentrifugation analyses, and immunochemical determinations. The weight average molecular weight as determined by sedimentation equilibrium ultracentrifugations was 54,000 and by sedimentation diffusion data 55,000. Amino acid analyses indicated a minimum of 110 amino acid residues per molecule. By determination of the minimum in the curve for the fraction of maximum deviation from the amino acid analyses it was found that the minimum molecular weight for the polypeptide was 12,200. Carbohydrate analyses demonstrated the presence f equimolar amounts of amnnose, galactose, and glucosamine, and the carbohydrate portion constituted 7.5% of the total weight. The amino acid analyses suggested that thyroxine-binding globulin is composed of 4 subunits. Molecular weight determinations by gel chromatography in 6 M guanidine hydrochloride indicated the presence of three species of globulin with apparent molecular weights 52,000, 25,000, and 13,500, respectively. Prolonged storage in guanidine hydrochloride promoted a more than 60% yield of the monomeric species. Moreover, a half-molecule of thyroxine-binding globulin was isolated and shown to consist of two polypeptide chains of similar molecular weight...
Partitioned Dimension: Modeling the Numerical Dimension in Data Warehouse (2010)

In the traditional data warehouse modeling, a numerical attribute with continuous data are not suitable for modeling as a dimension, unless it is partitioned into a concept hierarchy according to some predefined mapping-rules. In some cases, such rules are flexible or unavailable, so the partitioned dimension is proposed in this paper as the solution of modeling the numerical dimension in these cases. Partitioned dimension is generated by clustering the frequent query conditions. The query and dynamic OLAP operations over partitioned dimensions are also introduced. At last, some experiments show that the proposed modeling approach is effective and efficient.
Biomechanical and Biomaterial Considerations of Natural Teeth, Tooth Replacements, and Skeletal Fixation (1974)

AbstractThe biomechanics of natural teeth, anklyosed teeth, and various tooth substitute combinations were studied. It was found that the periodontal ligament totally dominates the biomechanics of normal teeth, acting as an effective shear transfer layer and minimizing stress concentrations in the socket wall. It was further found that most tooth replacement concepts severely disturb the biomechanics. One combination, acrylic plus steel, was found to reproduce quite accurately the natural biomechanics. It, therefore, poses promise as a functional tooth replacement.
A Sensitive Direct ELISA for Detection of Prostaglandin E <sub>2</sub> (2007)

Abstract In order to improve the indirect ELISA for detection of PGE2, a modified direct ELISA technique was developed to measure PGE2 in cell culture supernatants. An evaluation of three types of coating buffer showed that PGE2 was adsorbed efficiently to the solid phase using the gelatin phosphate buffer. The sensitivity of the assay was increased by employing polyclonal rabbit anti‐PGE2 antibody dilution of 1/100 and 1% skimmed milk as a blocking solution, with the detection limit of 7.8–500 ng/well. The within‐run and between‐run coefficients of variation (CV) ranges were 3.2–3.7% and 3.4–3.8%, respectively. A linear standard curve was observed over the range of 0.078–5 µg/mL with a coefficient of determination (r2) of 0.99. Our results indicated that the developed direct ELISA was sensitive and suitable for a quick determination of PGE2 levels from cell culture supernatants.
Dead-time effects on geiger-mode APD performance (2007)

Geiger mode avalanche photodiodes (GAPDs) are capable of detecting single photon events. However, once triggered, GAPDs must be reset or rearmed to enable the detection of another event. Thus, these devices are non-linear and their performance depends on the reset-time a.k.a. dead-time. In this paper, the performance of GAPD based ladar receivers is investigated and a theory for the signal photon detection efficiency (SPDE) is developed as a function of the dead-time; signal, noise and clutter flux; and the GAPD's photon detection efficiency or PDE. This SPDE theory is valid for arbitrary (short to long) dead-times. With a zero dead-time, GAPDs behave linearly and the SPDE theory converges to the PDE. For long dead-times, compared to the acquisition gate time, the theory converges to previously published works of Fouche and Williams. This SPDE theory is then applied to develop a theory for the detector signal-to-noise ratio (SNR). The performance improvement when multiple micro-pixels are grouped to form a macro pixel is also discussed.
Drug Delivery to the Oral Cavity (2005)

With contributions from recognized authorities in industry, academia, and government, this reference presents the state-of-the-art in the testing, formulation, and clinical evaluation of intraoral drug delivery products-summarizing intraoral dosage forms in various stages of research, as well as products currently on the market.
Symptoms and Well-Being in Relation to Glycemic Control in Type II Diabetes (1996)

These data suggest that better glycemic control in type II diabetes is associated with fewer physical symptoms, better mood, and better well-being, in a nonhypoglycemic HbA1c range.
Cryolipolysis: a historical perspective and current clinical practice. (2013)

Dermatologists have long used cold-based therapeutic approaches for a variety of applications. Based on the differences in chemical composition, it is possible to selectively target certain tissues rich with lipid, while sparing the surrounding tissue predominantly containing water. With historical observations of cold-induced panniculitis suggesting the feasibility of this strategy, cryolipolysis has emerged as a new methodology using controlled cooling to selectively target fat. Both preclinical and clinical studies have established the safety and efficacy of cryolipolysis for noninvasive body contouring. This review will focus on the evolution of cryolipolysis from initial case reports of cold-induced panniculitis, to preclinical and clinical studies, and the current clinical practice.
Refinery uses bioslurry process to treat RCRA wastes (1996)

Restrictions on land disposal of oily refinery wastes have forced the refining industry to develop cost-effective methods to treat these wastes before disposal. Valero Refining Company is using an onsite, tank-based biological treatment process to treat oily wastes at its Corpus Christi, Texas, refinery. This system consistently treats these wastes to RCRA universal treatment standards (UTS), thereby allowing direct disposal of the treated residue in a Resource Conservation and Recovery Act (RCRA) permitted landfill. In selecting the biotreatment process, Valero used several criteria including environmental performance, equipment reliability and ability to be integrated into refinery operations and process safety. Capital investment, maintenance and operating costs also were important considerations. This case history shows how Valero successfully used the bioslurry process to treat oily wastes such as API separator sludge and slop-oil emulsion before landfill disposal.
How High can a Range of Mountains get? (2003)

Abstract Rocks from the depths of the Earth can be found on its surface. They provide information on the thickness of continents and permit conclusions to be drawn regarding orogenic processes
Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase-3 in hippocampal neuroprogenitor cells (2005)

Dual specific protein kinase Dyrks are thought to play a key role in the regulation of cell growth in a variety of cellular systems. Interestingly, human Dyrk1 is mapped to the Down's syndrome (DS) critical region on chromosome 21, and thought to be a candidate gene responsible for the mental retardation of DS patients. Huntingtin-interacting protein 1 (Hip-1), a proapoptotic mediator, is implicated as a molecular accomplice in the pathogenesis of Huntington's disease. In the present study we found that Dyrk1 selectively binds to and phosphorylates Hip-1 during the neuronal differentiation of embryonic hippocampal neuroprogenitor (H19-7) cells. The Dyrk1-mediated phosphorylation of Hip-1, in response to bFGF, resulted in the blockade of Hip-1-mediated neuronal cell death as well as the enhancement of neurite outgrowth. Furthermore, the addition of etoposide to proliferating H19-7 cells caused the diminished binding of Hip-1 to Dyrk1 and the levels of phosphorylated Hip-1 remarkably decreased. Simultaneously, the dissociated Hip-1 from Dyrk1 bound to caspase-3 in response to etoposide, which led to its activation and consequently cell death in H19-7 cells. These data suggest that the phosphorylation of Hip-1 by Dyrk1 has a dual role in regulating neuronal differentiation and cell death. The interaction between Dyrk1 and Hip-1 appeared to be differentially modulated by different kinds of stimuli, such as bFGF and etoposide in H19-7 cells.
Emergence of Tetracycline Resistance in <i>Helicobacter pylori</i> : Multiple Mutational Changes in 16S Ribosomal DNA and Other Genetic Loci (2002)

Tetracycline is useful in combination therapies against the gastric pathogen Helicobacter pylori. We found 6 tetracycline-resistant (Tet(r)) strains among 159 clinical isolates (from El Salvador, Lithuania, and India) and obtained the following four results: (i) 5 of 6 Tet(r) isolates contained one or two nucleotide substitutions in one part of the primary tetracycline binding site in 16S rRNA (AGA(965-967) [Escherichia coli coordinates] changed to gGA, AGc, guA, or gGc [lowercase letters are used to represent the base changes]), whereas the sixth (isolate Ind75) retained AGA(965-967); (ii) PCR products containing mutant 16S ribosomal DNA (rDNA) alleles transformed recipient strains to Tet(r) phenotypes, but transformants containing alleles with single substitutions (gGA and AGc) were less resistant than their Tet(r) parents; (iii) each of 10 Tet(r) mutants of reference strain 26695 (in which mutations were induced with metronidazole, a mutagenic anti-H. pylori agent) contained the normal AGA(965-967) sequence; and (iv) transformant derivatives of Ind75 and of one of the Tet(r) 26695 mutants that had acquired mutant rDNA alleles were resistant to tetracycline at levels higher than those to which either parent strain was resistant. Thus, tetracycline resistance in H. pylori results from an accumulation of changes that may affect tetracycline-ribosome affinity and/or other functions (perhaps porins or efflux pumps). We suggest that the rarity of tetracycline resistance among clinical isolates reflects this need for multiple mutations and perhaps also the deleterious effects of such mutations on fitness. Formally equivalent mutations with small but additive effects are postulated to contribute importantly to traits such as host specificity and virulence and to H. pylori's great genetic diversity.
A 5-Gb/s Automatic Gain Control Amplifier With Temperature Compensation (2012)

This paper presents an automatic gain control (AGC) amplifier with temperature compensation for high-speed applications. The proposed AGC consists of a folded Gilbert variable gain amplifier (VGA), a dc offset canceller, inductorless post amplifiers, a linear open-loop peak detector (PD), an integrator, a symmetrical exponential voltage generator, and a compensation block for temperature stability. The novel temperature compensation scheme ensures the AGC stability and accuracy over <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${-}$</tex></formula> 20 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\,^{\circ}$</tex></formula> C–200 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\,^{\circ}$</tex></formula> C by predicting the integrator biasing voltage based on the crucial blocks duplication technique. The proposed linear open loop PD combined with the linear-in-dB VGA manages the dB-linear error of less than 0.3 dB for the received signal strength indication (RSSI). The AGC chip is fabricated using a 0.13- <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu$</tex></formula> m SiGe BiCMOS technology. Consuming a power of 72 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$~$</tex> </formula> mW from a 1.2-V supply voltage, the fabricated circuit exhibits a voltage gain of 40 dB and a 3-dB bandwidth of 7.5 GHz. With a 2 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$^{15}-$</tex></formula> 1 pseudo-random bit sequence at 5-Gb/s, the measured peak-to-peak jitter is less than 40 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\hbox {ps}}_{\rm pp}$</tex></formula> across the <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${-}$</tex></formula> 20 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\,^{\circ}$</tex></formula> C–200 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\,^{\circ}$</tex></formula> C temperature range. The low linear-in-dB error and the wide operating temperature range achieving the high-speed data input signal indicate the suitability of the proposed techniques for high-speed AGC amplifiers.
Genetic modifiers of vision and hearing (2002)

The identification of 'disease genes' and the mutations within them has greatly enhanced our understanding of normal function in the eye and ear. At the same time, it has become clear that these single-gene mutations must reside in a permissive genetic background for a disease phenotype to manifest. Segregating background genes can also modify the age of onset, rate of progression or severity of these diseases. These background genes that interact with the disease mutation and that are responsible for the specific phenotypes observed are commonly called genetic modifiers. Identification of these modifier genes may define the biological pathways that lead from the primary genetic defect to the aberrant phenotype. Once the identities of modifier genes that suppress vision or hearing loss become known, the door opens to new potential therapeutic targets, since these modifier genes may be more amenable to treatment than the primary mutant gene.
Temperature Control of Ultrasupercritical Once-through Boiler-turbine System Using Multi-input Multi-output Dynamic Matrix Control (2011)

Multi-input multi-output (MIMO) dynamic matrix control (DMC) technique is applied to control steam temperatures in a large-scale ultrasupercritical once-through boiler-turbine system. Specifically, four output variables (i.e., outlet temperatures of platen superheater, finish superheater, primary reheater, and finish reheater) are controlled using four input variables (i.e., two spray valves, bypass valve, and damper). The step-response matrix for the MIMO DMC is constructed using the four input and the four output variables. Online optimization is performed for the MIMO DMC using the model predictive control technique. The MIMO DMC controller is implemented in a full-scope power plant simulator with satisfactory performance.
ChemInform Abstract: A NEW SYNTHESIS OF ALPHA,BETA‐UNSATURATED ALDEHYDES INCLUDING (E)2‐METHYL‐2‐ALKENAL (1973)

Abstract Aus den Cycloalkanonen (Ia)‐(Ic) erhält man mit Dichlormethyllithium (II) die Addukte (III), aus denen beim Erhitzen über die Chlor‐aldehyde (IV) die 1‐Cycloalkenaldehyde (V) entstehen.
Seismic response of instrumented structures during the 1994 Northridge, California, earthquake (1995)

This paper presents an overview of strong motion records obtained from instrumented structures during the 1994 Northridge earthquake. It describes the behaviour of buildings, bridges, and dams that have been instrumented by the major strong motion instrumentation networks operating in California and highlights important features of the most significant structural motions recorded during the earthquake. The structural damage observed during a reconnaissance visit to the affected areas by the earthquake is correlated with preliminary analyses of the recorded motions. Detailed discussions of the dynamic behaviour of two instrumented reinforced concrete buildings that suffered damage during the earthquake are presented. The behaviour of these buildings during previous earthquakes is also examined. This paper and the companion paper on ground motions provide comprehensive information about instrumental records obtained in the region affected by the earthquake. Key words: earthquake engineering, structural response, strong motion instrumentation, damage evaluation, buildings, bridges, dams, structural dynamics, acceleration, amplification.
A canine model of induced purine nucleoside phosphorylase deficiency. (1986)

Purine nucleoside phosphorylase (NP EC 2.4.2.1) deficiency in man is associated with selective T cell dysfunction and normal B cell immunity. To create an in-vivo model of this immune deficiency, we administered 8-aminoguanosine to dogs. This water soluble nucleoside was rapidly converted by NP to the more potent product inhibitor 8-aminoguanine, which had a Ki of 0.52 microM. The accumulation of inosine and exogenous deoxyguanosine in plasma provided evidence that administration of 8-aminoguanosine was effectively inhibiting NP activity. Four dogs given 8-aminoguanosine and deoxyguanosine concurrently for 5 consecutive days showed mean reductions in peripheral blood lymphocytes of 65 +/- 9% range (55-75%) over the test period. Granulocytes, red blood cells, and plateletes remained within the normal range. Administration of 8-aminoguanosine to dogs provides a model of NP deficiency that will permit studies of the specific control of lymphopoiesis and in-vivo immune function.
Effect of Sulfuric Acid Treatment and Calcination on Natural Zeolites of Indonesia (2015)

Asian Journal of Chemistry, a Multidisciplinary Chemistry Journal is an Peer Reviewed International Journal and publishes from India. The journal has been established since January 1989 on a firm foundation of International Quality Research. This Journal encompasses all branches of chemistry and its sub – disciplines like Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry, etc.
Azodyes as Photoalignment Materials for Polymerizable Liquid Crystals (2007)

We demonstrate the excellent photoalignment capability of sulfuric azodyes for polymerizable liquid crystals (PLC) whose anisotropic films are extensively studied as basic elements of many passive optical devices (e.g., retardation films, polarizers, and color filters). These dyes exhibit a high affinity to various substrates and insolubility in PLC and organic solvents commonly used for their dilution. An extremely low exposure dose (less than 50 mJ) is needed to induce an excellent planar alignment of PLC. This alignment can be easily patterned using minimal numbers of masks and exposure steps. No sign of alignment deterioration is observed after photopolymerization. These imply that new photoalignment materials can be effectively used for the industrial production of optical films based on PLC. Particularly, they suit the continuous manufacturing process for such films.
Substituted vitamin K epoxide analogs. New competitive inhibitors and substrates of vitamin K1 epoxide reductase (1990)

2- and 3-substituted vitamin K 2,3-epoxide analogues were synthesized and tested as inactivators, inhibitors, and substrates for beef liver microsomal vitamin K1 epoxide reductase. 2-(X)-3-phytyl-1,4-naphthoquinone 2,3-epoxides, where X is hydroxymethyl, chloromethyl, fluoromethyl, difluoromethyl, and formyl were all competitive inhibitors, but none was an inactivator. Only the 2-hydroxymethyl analogue was reduced to a quinone that was stable enough under the conditions of the experiment to be detected. Vitamin K1 epoxide analogues with modified phytyl chains (1'-hydroxy, 3'-fluoro with isomerized double bond, 1'-hydroxy and 1'-fluoro with saturated double bond, and the corresponding unsubstituted chains) were synthesized. All of the analogues were competitive inhibitors of vitamin K1 epoxide reductase. The nonfluorinated analogues also were shown to be substrates, being reduced to the corresponding quinone without enzyme inactivation. At least one other enzyme besides vitamin K1 epoxide reductase in beef liver microsomes also metabolizes all of these analogues.
Dry Fibrin Sealant Dressings Reduce Blood Loss, Resuscitation Volume, and Improve Survival in Hypothermic Coagulopathic Swine with Grade V Liver Injuries (1999)

In swine with a grade V liver injury complicated by a dilutional and hypothermic coagulopathy, DFSD provided simple, rapid hemorrhage control, decreased fluid requirements, and improved survival.
Phase III Study of Gefitinib Compared With Intravenous Methotrexate for Recurrent Squamous Cell Carcinoma of the Head and Neck (2009)

In patients with recurrent or metastatic SCCHN, while responses with gefitinib were seen, neither gefitinib 250 nor 500 mg/day improved overall survival compared with methotrexate. With the exception of tumor hemorrhage-type events with gefitinib, the adverse event profiles were generally consistent with those previously observed.
Ein neuer Rhynchites des paläarktischen Faunengebietes. (Col.) (1907)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
The Effects of Meperidine and Sufentanil on the Shivering Threshold in Postoperative Patients  (1998)

At a given dose, sufentanil inhibited shivering 2,800 times better than meperidine. However, the equianalgesic ratio of these drugs is approximately 4,900. That is, meperidine inhibited shivering better than would be expected based on the equianalgesic potency ratio. These data are thus consistent with clinical observations suggesting that meperidine indeed possesses special antishivering activity.