gebhart/patrepeval huggingface dataset:
Selective expression and constitutive phosphorylation of SHC proteins [corrected] in the CD34+ fraction of chronic myelogenous leukemias. (2000)

The BCR/ABL fusion protein is a constitutively active tyrosine kinase that is responsible for the pathogenesis of chronic myelogenous leukemia (CML). Clinically, CML is characterized by a chronic phase (CP) that eventually terminates into a blast crisis (BC). BC transformation is associated with accumulation of CD34+ blasts. We investigated the expression and phosphorylation of Src-homology-2 and collagen-homology domains (SHC) [corrected] proteins in subpopulations of CML primary cells. Shc polypeptides are tyrosine kinase substrates that are constitutively tyrosine-phosphorylated in continuous cell lines of CML origin. High levels of Shc expression were found in the CD34+ cells from CML-BC, CML-CP and normal bone marrow. In contrast, CD34- fractions from CML-CP and normal bone marrow expressed low levels of p46Shc. Shc proteins were constitutively phosphorylated in the CD34+ fractions from CML cells (both CP and BC), but not in normal CD34+ cells. These data bear implications for the role of Shc in normal hemopoiesis and CML leukemogenesis: (a) dramatic changes of Shc expression during terminal differentiation of hemopoietic cells adds a further level of regulation to the signal transduction function of Shc; and (b) constitutive Shc tyrosine-phosphorylation in the rare CD34+ cells of CML-CP might contribute to the selection of this subpopulation during the blast crisis transformation of CMLs.
Current-induced spin–orbit torque magnetization switching in a MnGa/Pt film with a perpendicular magnetic anisotropy (2016)

Abstract Current-induced magnetization switching is demonstrated in a micron sized Hall bar consisting of Pt-capped ultrathin ferrimagnetic MnGa films. The films showed a low magnetization M s ≃ 150 kA/m and a large perpendicular magnetic anisotropy (PMA) field T, indicating a PMA thickness t product mJ/m 2 , which is relatively larger than those reported for other material films with PMA. Magnetization switching induced by an in-plane electrical current was examined with the application of an in-plane magnetic field. The phase diagram of the switching current vs the in-plane magnetic field is qualitatively consistent with that of the torque due to the spin-Hall effect in the Pt layer.
LOSSES IN TITANIUM-DIFFUSED LITHIUM-NIOBATE CHANNEL WAVEGUIDES DUE TO DIRECTIONAL CHANGES (1980)

The optical transmission characteristics of dielectric optical waveguides having directional changes is considered in this study. Experimental and theoretical loss results are presented for two types of waveguide bends. First is the corner bend where two straight waveguides are joined together at some angle. The second type is a curved waveguide having some radius of curvature. The loss mechanism is different for each type of bend. The corner bend is basically a scattering loss due to a mismatch of the modes of the two joining waveguides. The loss in the curved waveguide is due to radiation of the energy away from the waveguide as it propagates around the bend. The waveguides were fabricated by diffusing 3 μm wide 200 Å thick titanium strips into LiNbO₃. All of the curved portions of waveguide were joined by straight waveguides at the input and output of the curved waveguides. Rayleigh scattering and absorption loss was measured in the straight waveguides to determine their optical quality which yielded about 1.4 dB/cm. The loss due to corner bends was measured for angles from 0.1° to 3.0° in steps of 0.1°. The loss ranged from about 0.1 dB to 23 dB for 0.1° and 3.0° respectively. The results are slightly dependent upon the polarization of the light and the orientation of the LiNbO₃ crystal. The curved waveguides were fabricated in two different geometries. The first geometry was a straight waveguide joined by a curved portion and then joined by another straight waveguide. The second geometry is different from the first by another curved portion joining the first curved portion in between the two straight waveguides. The two curved portions are equal but have opposite curvature which have an S shape. The radiation loss was measured for radius of curvatures from 1.0 cm to 3.0 cm. The results ranged from 41 dB/cm to 1 dB/cm for 1.0 cm and 3.0 radius of curvatures respectively. At each of the straight to curved and curved to curved junctions there exists a mode mismatch loss. The straight to curved mode mismatch loss was 1.65 dB for R = 1 cm and 0.5 dB for R = 3 cm. The curved to curved mode mismatch loss was 6 dB for R = 1 cm and 0.5 for R = 3 cm. The results for the corner bends and the curved bends were used to study the constraints on integrated optical devices. In many integrated optical devices, it is necessary for two different straight portions of a single mode channel waveguide to be connected with a given amount of transverse offset. The experimental and theoretical results showed that for small transverse offsets the corner bend approach yields smaller loss. The curved bend (S bend) approach was better for larger transverse offsets. Theory was developed for this study of bending loss in titanium diffused LiNbO₃ waveguides. In general all of the experimental results agreed quite well with the theoretical predictions.
Shape similarity assessment of polyhedral parts based on boundary models (2000)

Shape similarity evaluation is the core technology for many intelligent CAD/CAM applications. In this work a method to evaluate the shape similarity of polyhedral objects based on their boundary models is presented. The proposed method takes the unique boundary models of a query part and a reference part as its input and returns the match coefficient between these two parts. The match coefficient is calculated based on the 'feasible match' of the boundary faces, which is a set of matched faces that preserve the face adjacency relationships. While directly searching for the optimal feasible match in two boundary models could be computationally intractable, a divide-and-conquer method is proposed in this work to find a near-optimal match in a reasonable time. The divide stage corresponds to the extraction and matching of 'sweep features'. A sweep feature of a polyhedral object is a set of parallel faces that are sorted along their common normal vector. The sorted faces in sweep features are matched through an efficient constraint-directed tree search to generate intermediate matches. The intermediate matches that are orientation consistent are merged to form the final feasible matches. A prototype system based on the proposed methodology has been implemented and shape similarity comparison results between various mechanical parts with complicated intersecting features are presented.
The student counsellor as a team member (1976)

Abstract Describing the future roles and services of British counsellors in higher and further education must not be done in professional isolation. We need to consider how the future roles of professional counsellors will positively affect the counselling done by academic staff Furthermore, rather than making generalisations about counselling needs, it may be better for working parties or task forces to develop counselling models which are appropriate to particular institutions. Such task forces should address some of the pressing issues confronting academic institutions: for example, (1) the revitalisation of the curriculum; (2) the improvement of the out-of-classroom relationships between academic staff and students; and (3) the development and maintenance of effective systems of academic government. If counsellors are to develop services which will help to resolve some of the problems associated with these issues, they will have to be increasingly clear about their own values.
Regulation of Clostridium acetobutylicum metabolism as revealed by mixed-substrate steady-state continuous cultures: role of NADH/NAD ratio and ATP pool (1994)

Glycerol-glucose-fed (molar ratio of 2) chemostat cultures of Clostridium acetobutylicum were glucose limited but glycerol sufficient and had a high intracellular NADH/NAD ratio (I. Vasconcelos, L. Girbal, and P. Soucaille, J. Bacteriol. 176:1443-1450, 1994). We report here that the glyceraldehyde-3-phosphate dehydrogenase, one of the key enzymes of the glycolytic pathway, is inhibited by high NADH/NAD ratios. Partial substitution of glucose by pyruvate while maintaining glycerol concentration at a constant level allowed a higher consumption of glycerol in steady-state continuous cultures. However, glycerol-sufficient cultures had a constant flux through the glyceraldehyde-3-phosphate dehydrogenase and a constant NADH/NAD ratio. A high substitution of glucose by pyruvate [P/(G+P) value of 0.67 g/g] provided a carbon-limited culture with butanol and butyrate as the major end products. In this alcohologenic culture, the induction of the NADH-dependent butyraldehyde and the ferredoxin-NAD(P) reductases and the higher expression of alcohol dehydrogenases were related to a high NADH/NAD ratio and a low intracellular ATP concentration. In three different steady-state cultures, the in vitro phosphotransbutyrylase and butyrate-kinase activities decreased with the intracellular ATP concentration, suggesting a transcriptional regulation of these two genes, which are arranged in an operon (K. A. Walter, R. V. Nair, R. V. Carry, G. N. Bennett, and E. T. Papoutsakis, Gene 134:107-111, 1993).
Evaluation of antimicrobial interactions between chlorhexidine, quaternary ammonium compounds, preservatives and excipients (1992)

The antimicrobial interactions of 49 combinations of chlorhexidine, quaternary ammonium compounds, preservatives and excipients were evaluated by the method of Berenbaum and the checkerboard titration method, with Staphylococcus aureus CIP 53154 and Escherichia coli CIP 54127 as test strains. MIC determinations were carried out as a preliminary step, and relative growth intensity was used to describe the bacteriostatic activity of surface-active agents (Amonyl 380 BA, Amonyl 671 SB). In the study of combinations, results were interpreted with Fractional Inhibitory Concentration indexes and represented by isobolograms. A fair correlation was shown between the method of Berenbaum and the checkerboard titration method. Combinations between chlorhexidine, cetrimonium bromide and benzalkonium chloride were synergistic or additive; combinations of antiseptics and preservatives were generally not antagonistic. The methods were also well adapted to the study of interactions involving surface-active agents, a critical problem in the formulation of topical antimicrobial agents.
Cure behavior and thermal stability analysis of multiwalled carbon nanotube/epoxy resin nanocomposites (2008)

Abstract As‐received multiwalled carbon nanotubes (MWCNTs) were first treated by a 3 : 1 (v/v) mixture of concentrated H 2 SO 4 /HNO 3 and further functionalized by ethylenediamine/dicyclohexylcarbodiimide/tetrahydrofuran solution. MWCNT/epoxy nanocomposites were prepared. Their cure behaviors were investigated by dynamic differential scanning calorimetry. Quantitative analysis of the activation energy as a function of the degree of curing was carried out by the Flynn‐Wall‐Ozawa method. The fitted multiple regression equations for values of the activation energy of different systems were obtained. MWCNTs have the retardation effect on the cure reaction of epoxy resin, while the functional groups on the surface of amine‐modified MWCNTs could accelerate the cure reactions. Thermal stability was studied by thermogravimetric analysis. The filling of amine‐modified MWCNTs is beneficial to lower the cure activation energy and improve thermal stability of the nanocomposite. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Integrating Document Management with Project and Company Data (2000)

Electronic document management (EDM) systems have revolutionized the construction document storage and retrieval process. An electronically managed document consists of a computer representation of the main document body, usually in the form of a bitmap, and a reference or indexing structure used to retrieve the document. In construction, the reference data includes information that relates the document to certain aspects of the constructed facility and the construction company. It is argued that this relationship needs to be represented explicitly and in an integrated manner as opposed to the approach used by traditional EDM systems. This paper presents an integrated approach based on the concept of specialized construction data models. A detailed account of how this approach was followed to integrate a quality assurance document management system within a steel fabrication company is also presented.
Fiber-optic microbend sensor structure (1997)

We proposed and experimentally investigated a novel microbend sensor structure. The structure is composed of single-mode leads and multimode sensing fiber. The proposed structure exhibited a level of sensitivity as much as six times higher than that of the classical microbend sensor configuration when the same sensing fiber was used. Additionally, single-mode leads reduce lead noise and allow the use of more-coherent sources. The total loss of the proposed nondeformed structure is near 2 dB when the proper splicing method is used.
Testing Nc Machine Tools With the Circular Test (1985)

A new method to test NC-machine tools, the Circular Test, is introduced and described. The test is used to show and evaluate errors that are caused by the numerical control or by geometrical errors.
Terminal oxidases of Escherichia coli aerobic respiratory chain. I. Purification and properties of cytochrome b562-o complex from cells in the early exponential phase of aerobic growth. (1984)

Cytochrome b562-o complex, a terminal oxidase in the respiratory chain of aerobically grown Escherichia coli K12, was isolated in a highly purified form. The purified oxidase is composed of equimolar amounts of two polypeptides, with Mr = 33,000 and 55,000, determined by gel electrophoresis in the presence of sodium dodecyl sulfate. It contains 19.5 nmol of heme and 16.8 nmol of copper/mg of protein, but no detectable nonheme iron, phospholipid, ubiquinone, or menaquinone. In the difference spectrum at room temperature, the oxidase shows a single alpha absorption peak at 560 nm and at 77 K it shows two alpha absorption peaks at 555 and 562 nm. This oxidase combines with CO and the CO difference spectrum at room temperature has a peak at 416 nm and a trough at 430 nm in the Soret region. Its oxidation-reduction potential is estimated to be 125 mV (pH 7.4) and it is pH-dependent (-60 mV/pH) in medium of pH 6.0 to 7.4. It catalyzes electron transport to oxygen via ubiquinol and ascorbate in the presence of phenazine methosulfate or N,N,N',N'-tetramethyl-p-phenylenediamine dihydrochloride. This oxidase activity depends on phospholipids and is sensitive to respiratory inhibitors, such as 2-heptyl-4-hydroxyquinoline N-oxide, piericidin A, KCN and NaN3. The divalent cations Zn2+, Cd2+, and Co2+ inhibit the oxidase activity extensively. The oxidase activity of the cytochrome b562-o complex was inhibited by photoinactivation with rose bengal, suggesting that the inhibition by zinc ion results from modification of a histidine residue of cytochrome o.
XI.—NEW BOOKS (1967)

Journal Article XI.—NEW BOOKS Get access The Perceptual Process. By A. CAMPBELL GARNETT. The University of Wisconsin. London: George Allen and Unwin Ltd., Ruskin House, Museum Street, 1965. Pp. 101. 21s. net. H. H. PRICE H. H. PRICE Search for other works by this author on: Oxford Academic Google Scholar Mind, Volume LXXVI, Issue 302, April 1967, Pages 287–293, https://doi.org/10.1093/mind/LXXVI.302.287 Published: 01 April 1967
Preparation of Palladium Colloids in Block Copolymer Micelles and Their Use for the Catalysis of the Heck Reaction (1997)

Colloidal dispersions of nanometer sized palladium colloids with very high stability were prepared in block copolymer micelles of polystyrene-b-poly-4-vinylpyridine and analyzed by electron microscopy and X-ray analysis. The resulting polymer/metal hybrids can easily be dissolved and handled in standard organic solvents such as toluene, tetrahydrofuran, and cyclohexane. They were successfully used for the Pd-catalyzed carbon−carbon coupling of aryl halides with alkenes (Heck reaction). Such block copolymer stabilized palladium colloids exhibit about the same reactivity as low molecular weight Pd complexes classically used for the Heck reaction, but show a much higher stability: in most reactions, the hybrids remain catalytically active even after 50000 turn-over cycles. Reaction rates were significantly controlled by the reactivity of the educts, but also respond to micelle architecture and dispersity of the palladium. Other advantages of the block copolymer stabilizer are that they are more simple and readily accessible than the phosphor-containing chelates, and that they dissolve even in “simple” solvents such as toluene (instead of amidic solvents).
Registration for 3D surfaces with large deformations using quasi-conformal curvature flow (2011)

A novel method for registering 3D surfaces with large deformations is presented, which is based on quasi-conformal geometry. A general diffeomorphism distorts the conformal structure of the surface, which is represented as the Beltrami coefficient. Inversely, the diffeomorphism can be determined by the Beltrami coefficient in an essentially unique way. Our registration method first extracts the features on the surfaces, then estimates the Beltrami coefficient, and finally uniquely determines the registration mapping by solving Beltrami equations using curvature flow. The method is 1) general, it can search the desired registration in the whole space of diffeomorphisms, which includes the conventional searching spaces, such as rigid motions, isometric transformations or conformal mappings; 2) global optimal, the global optimum is determined by the method unique up to a 3 dimensional transformation group; 3) robust, it handles large surfaces with complicated topologies; 4) rigorous, it has solid theoretic foundation. Experiments on the real surfaces with large deformations and complicated topologies demonstrate the efficiency, robustness of the proposed method.
A combined current voltage sensor for metering and protection in high voltage power systems (1994)

This paper describes a patented Poynting-vector transducer for the simultaneous measurement of both current and voltage in a high voltage power system. It also describes its application for protective relaying, high voltage metering, and measurement of losses in large transformers and shunt reactors. The principle of operation is based on the measurement of the Poynting vector from its constituent electric and magnetic fields in a very well-defined region of space around the high voltage conductor. The signals from the current and voltage sensors are processed by simple electronic circuits to bring them to the form and level required by the computers, meters, and relays. The new transducer is also ideally suitable for integration as a module in gas-insulated busbar duct system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Susceptibility of <i>Campylobacter pylori</i> Isolated from Pediatric and Adult Patients to Seven New Quinolone Antibiotics and Nalidixic Acid (1988)

The susceptibility of 26 strains of Campylobacter pylori to 7 new quinolone antibiotics and nalidixic acid was determined. All strains were resistant to nalidixic acid. Difloxacin, A-56620, A-62254, and ciprofloxacin were equally effective against the test strains with MICs ranging from 0.06 to 2.0 micrograms/ml. Fleroxacin, amifloxacin, perfloxacin, and norfloxacin showed only moderate activity against C. pylori. The new quinolone agents, which are bactericidal, may prove useful in the eradication of C. pylori from the gastric mucosa.
Federated End-to-End Authentication for the Constrained Internet of Things Using IBC and ECC (2015)

Authentication of smart objects is a major challenge for the Internet of Things (IoT), and has been left open in DTLS. Leveraging locally managed IPv6 addresses with identity-based cryptography (IBC), we propose an efficient end-to-end authentication that (a) assigns a robust and deployment-friendly federation scheme to gateways of IoT subnetworks, and (b) has been evaluated with a modern twisted Edwards elliptic curve cryptography (ECC). Our early results demonstrate feasibility and promise efficiency after ongoing optimizations.
Modified Wolff model for determination of resonance frequency of dielectric covered circular microstrip patch antenna (1991)

A new modified Wolff model (MWM) is proposed to calculate the resonance frequency of the circular covered and uncovered patch. For uncovered patches the calculated frequency using the MWM is within 0.5% of the measured value. For covered patch antennas, the MWM determines resonance frequency to within 1% of the results using from SDA.
Isolation and characterization of the 7S RNA gene from Methanococcus voltae (1989)

The gene encoding the 7S RNA of the archaebacterium Methanococcus voltae has been isolated. The gene occurs as a single copy within the genome and encodes an RNA molecule approximately 300 nucleotides in length. The M. voltae RNA molecule exhibits a strong similarity to both archaebacterial and eucaryotic 7S RNAs in terms of overall secondary structure, while the primary sequence is conserved to a lesser degree. All 7S RNA molecules possess a specific structural domain which is highly conserved in terms of both primary sequence and secondary structure, possibly representing a functional site of the molecule. Conservation of the 7S RNA molecule suggests that it is the descendant of a subcellular structure present before the divergence of the archaebacterial and eucaryotic kingdoms. The M. voltae 7S RNA gene is flanked both 5' and 3' by regions of extremely A + T-rich DNA. The 5'-flanking region contains several potential promoter sequences for archaebacterial RNA polymerases. One such sequence occurs as three direct repeats and bears a strong similarity to sequences found upstream of other archaebacterial genes. The 3'-flanking region contains a strong signal for the termination of transcription.