gebhart/patrepeval huggingface dataset:
Cognitive performance in surgically menopausal women on estrogen (2000)

<b><i>Article abstract</i></b> Estrogen replacement therapy (ERT) may help maintain normal cognitive function. Nondemented surgically menopausal women on ERT (n = 10) enrolled in a longitudinal aging study performed better than age- and education-matched control subjects (n = 25) on selected tests of verbal memory and constructional ability. These results suggest that ERT initiated soon after surgical menopause can have long-term neuroprotective effects in cognitively intact women.
Unfiltered Monte Carlo-based tungsten anode spectral model from 20 to 640 kV (2014)

A Monte Carlo-based tungsten anode spectral model, conceptually similar to the previously-developed TASMIP model, was developed. This new model provides essentially unfiltered x-ray spectra with better energy resolution and significantly extends the range of tube potentials for available spectra. MCNPX was used to simulate x-ray spectra as a function of tube potential for a conventional x-ray tube configuration with several anode compositions. Thirty five x-ray spectra were simulated and used as the basis of interpolating a complete set of tungsten x-ray spectra (at 1 kV intervals) from 20 to 640 kV. Additionally, Rh and Mo anode x-ray spectra were simulated from 20 to 60 kV. Cubic splines were used to construct piecewise polynomials that interpolate the photon fluence per energy bin as a function of tube potential for each anode material. The tungsten anode spectral model using interpolating cubic splines (TASMICS) generates minimally-filtered (0.8 mm Be) x-ray spectra from 20 to 640 kV with 1 keV energy bins. The rhodium and molybdenum anode spectral models (RASMICS and MASMICS, respectively) generate minimally-filtered x-ray spectra from 20 to 60 kV with 1 keV energy bins. TASMICS spectra showed no statistically significant differences when compared with the empirical TASMIP model, the semi-empirical Birch and Marshall model, and a Monte Carlo spectrum reported in AAPM TG 195. The RASMICS and MASMICS spectra showed no statistically significant differences when compared with their counterpart RASMIP and MASMIP models. Spectra from the TASMICS, MASMICS, and RASMICS models are available in spreadsheet format for interested users.
Inhibition of the Proteasome Activity by Gallium(III) Complexes Contributes to Their Anti–Prostate Tumor Effects (2007)

The investigation of metal-based complexes with potential antitumor activity has been of paramount importance in recent years due to the successful use of cisplatin against various cancers. Gallium(III) and subsequently developed gallium(III)-containing complexes have shown promising antineoplastic effects when tested in a host of malignancies, specifically in lymphomas and bladder cancer. However, the molecular mechanism responsible for their anticancer effect is yet to be fully understood. We report here for the first time that the proteasome is a molecular target for gallium complexes in a variety of prostate cancer cell lines and in human prostate cancer xenografts. We tested five gallium complexes (1-5) in which the gallium ion is bound to an NN'O asymmetrical ligand containing pyridine and substituted phenolate moieties in a 1:2 (M/L) ratio. We found that complex 5 showed superior proteasome inhibitory activity against both 26S proteasome (IC50, 17 micromol/L) and purified 20S (IC50, 16 micromol/L) proteasome. Consistently, this effect was associated with apoptosis induction in prostate cancer cells. Additionally, complex 5 was able to exert the same effect in vivo by inhibiting growth of PC-3 xenografts in mice (66%), which was associated with proteasome inhibition and apoptosis induction. Our results strongly suggest that gallium complexes, acting as potent proteasome inhibitors, have a great potential to be developed into novel anticancer drugs.
Nutritive Value of Salt-bed Roasted Soybeans for Broiler Chicks (1974)

A roaster was built which used heated granular salt (NaCl) as the heat transfer medium. Rapid and uniform roasting of soybeans was accomplished using such equipment. A 33 factorial experimental design was used to determine the effect of the roasting variables on soybeans. Chicken feeding trials and soybean protein availability measurements were used for evaluation. The best roasting conditions were 272° C. salt bed, 20 sec. contact of salt and soybean, and 120 sec. holding time. These roasting conditions also reduced the soybean moisture. Chicken rations containing soybeans roasted at these conditions produced 41 percent and three percent higher weight gains than a raw soybean diet and a commercial soybean meal diet, respectively, at the end of fourth week. It was concluded that the salt bed roasted soybeans were excellent for chick growth.
원보 / 백두옹의 소염진통작용 (2000)

The root extract of pulsatilla koreana has been used as antibacterial, antiparasitic and anti-inflammatory analgesic agents in Traditional Medicine in Korea. Thus anti-inflammatory and analgesic actions of the methanol and water extracts of the root were investigated by administration in oral and intravenous route. From the results, it is concluded that the extracts exhibited the potent anti-inflammatory and analgesic actions in intravenous administration, but did not show the actions in oral administration in animals.
PENNSYLVANIA'S EXPERIENCE WITH THE DESIGN, CONSTRUCTION AND PERFORMANCE OF GUSSASPHALT (1977)

The purpose of the research project described is to evaluate the mixing and placing characteristics of the Gussasphalt and determine the immediate and long-range performance of the paving system.
Accelerated Hough transform usingrectangular image decomposition (1996)

A novel fast method for evaluating the Hough transform is proposed, which can be used to accelerate detection of prevalent linear formations in binary images. An image is decomposed using rectangular blocks and the contribution of each whole block to the Hough transform space is evaluated, rather than the contribution of each image point. The resulting acceleration in the calculation of the Hough transform field is demonstrated in two image processing experiments related to object axis identification and skew detection of digitised documents.
Reactions of Alcohols and Phenols with Trimethylene Oxide<sup>1</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Alcohols and Phenols with Trimethylene Oxide1S. Searles and C. F. ButlerCite this: J. Am. Chem. Soc. 1954, 76, 1, 56–58Publication Date (Print):January 1, 1954Publication History Published online1 May 2002Published inissue 1 January 1954https://pubs.acs.org/doi/10.1021/ja01630a015https://doi.org/10.1021/ja01630a015research-articleACS PublicationsRequest reuse permissionsArticle Views329Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phase Processing for Single-Channel Speech Enhancement: History and recent advances (2015)

With the advancement of technology, both assisted listening devices and speech communication devices are becoming more portable and also more frequently used. As a consequence, users of devices such as hearing aids, cochlear implants, and mobile telephones, expect their devices to work robustly anywhere and at any time. This holds in particular for challenging noisy environments like a cafeteria, a restaurant, a subway, a factory, or in traffic. One way to making assisted listening devices robust to noise is to apply speech enhancement algorithms. To improve the corrupted speech, spatial diversity can be exploited by a constructive combination of microphone signals (so-called beamforming), and by exploiting the different spectro?temporal properties of speech and noise. Here, we focus on single-channel speech enhancement algorithms which rely on spectrotemporal properties. On the one hand, these algorithms can be employed when the miniaturization of devices only allows for using a single microphone. On the other hand, when multiple microphones are available, single-channel algorithms can be employed as a postprocessor at the output of a beamformer. To exploit the short-term stationary properties of natural sounds, many of these approaches process the signal in a time-frequency representation, most frequently the short-time discrete Fourier transform (STFT) domain. In this domain, the coefficients of the signal are complex-valued, and can therefore be represented by their absolute value (referred to in the literature both as STFT magnitude and STFT amplitude) and their phase. While the modeling and processing of the STFT magnitude has been the center of interest in the past three decades, phase has been largely ignored.
THE BETA DISTRIBUTION, MOMENT METHOD, KARL PEARSON AND R.A. FISHER (2007)

Simulation studies provide four moment approximating distributions to each of the four parameters of a beta distribution (Pearson Type I). Two of the parameters refer to origin and scale, two to shape (skewness and kurtosis). Type I random number generator is checked out, and the stability of moments of random samples of size n over cycles; particular attention is paid to shape parameter moments. In Type I region of validity (referred to skewness and kurtosis), moment methods become unstable in the neighborhood of Type III ({chi}{sup 2}) line, and ultimately abort. Thus extremely large variances and large higher moments arise. We probe the cause of this phenomenon. Simulation studies are turned to since alternative power series methods are forbiddingly complicated. However, use is made of the delta method to provide asymptotic variances of the estimators, and asymptotic variances of percentage points of the basic distribution. An account of work on the subject by K. Pearson, some of it a century ago, is given. In particular an important paper by Pearson and Filon provides some estimates of probable errors of moment parameter estimators such as the basic distribution parameters, the mode, the skewness and others. The heated controversy between Pearson andmore » Fisher is considered.« less
Studies on the Catalysts for Coal Liquefaction. Specific Behavior of Various Catalysts in the Hydrogenolysis of Model Compounds (Additive Effect of Tetralin). (1991)

Six kinds of model compounds were subjected to catalytic hyd-rogenolysis in tetralin as a hydrogen-donor solvent at 653K. Ten kinds of catalysts were employed and the additive effect of tetralin on the reaction profiles was discussed. Three kinds of model compounds that scarcely reacted at 653K were subjected to hydrogenolysis at 693K, and the temperature effect was discussed. The additive effect of tetralin was clas-sified into four categories as follows: (1) tetralin increases the overall conversion, (2) tetra-lin decreases the overall conversion, (3) the overall conversion is not varried obviously but the composition of products is changed by an addition of tetralin, (4) neither the overall conversion nor the compositionof products is varied by an addition of tetralin. Thus, the effect of tetralin added was specific for the individual reaction system. The increase in reaction temperature accelerates the reactions which were retarded on addition of tetralin, but it seemed that the conversions were still lower than those for the reactions at 653 K without addition of tetralin.
β <sub>2</sub> -Microglobulin—A Free Immunoglobulin Domain (1972)

Analysis of the primary structure of beta(2)-microglobulin indicates that this human protein is homologous in sequence to the constant portion of immunoglobulin light chains (C(L)), and to the homology regions (C(H)1, C(H)2, and C(H)3) of the constant portion of gamma1 (heavy) chains of immunoglobulin G. Homology with the C(H)3 region is particularly striking. No convincing homology could be demonstrated by similar comparisons with the variable regions of immunoglobulin light and heavy chains. beta(2)-Microglobulin contains an intrachain disulfide loop of 57 amino-acid residues that is similar in size to disulfide loops found in the constant regions of immunoglobulin G. These findings suggest that beta(2)-microglobulin is a free immunoglobulin domain, possibly serving an effector function similar to that of the C(H)3 domain of gamma1 chains of immunoglobulin G.
Predicting Attitude and Actions of Twitter Users (2016)

In this paper, we present computational models to predict Twitter users' attitude towards a specific brand through their personal and social characteristics. We also predict their likelihood of taking different actions based on their attitudes. In order to operationalize our research on users' attitude and actions, we collected ground-truth data through surveys of Twitter users. We have conducted experiments using two real world datasets to validate the effectiveness of our attitude and action prediction framework. Finally, we show how our models can be integrated with a visual analytics system for customer intervention.
Complex Impacts of PI3K/AKT Inhibitors to Androgen Receptor Gene Expression in Prostate Cancer Cells (2014)

PI3K/AKT inhibitors have off-target effects on AR gene expression in prostate cancer cells, which shall be considered when applying these inhibitors to PCa patients, particularly patients under ADT treatment.
Predicting timing violations through instruction-level path sensitization analysis (2012)

In this paper, we present a novel technique for early prediction of timing violations in high-performance pipelined microprocessors. We show that a static instruction in a microprocessor, identified by its Program Counter (PC), is an excellent predictor of an upcoming timing violation. Our analysis combines architectural data collected from real program execution with gate level logic analysis. Exploiting this PC based timing violation predictability, we propose a robust system design that predicts and tolerates timing violations seamlessly in a pipelined microprocessor. Under two different faulty environments, we show 20.9-89.8% and 14.6-80.6% average performance improvements in real programs over other state-of-the-art techniques, respectively.
The active-clamp couple-buck converter-a novel high efficiency voltage regulator modules (2002)

As the power demand for microprocessors increases steadily, the VRMs are required to work with a higher input voltage. The widely used synchronous buck converter will NOT work properly and efficiently for this higher input voltage because of an extremely small duty-ratio, This paper proposes a novel active-clamp couple-buck converter to solve the extremely small duty-ratio problem, Other benefits of the proposed circuit include recovery leakage energy, clamped device voltage and reduced input filter. The proposed circuit was demonstrated on a 4-phase VRM, which delivers power from a 12 V input to a 1.5 V/50 A microprocessor load. Experiments show that the proposed circuit would significantly improve the VRM efficiency.
Evaluation of Collapse Strength of Cemented Pipe-in-Pipe Casing Strings (1985)

ABSTRACT The first test series has proved the high collapse strength of a combination of 5" casing cemented into 7" casing and the importance of high strength cement /5/. The extent of the tests included twelve pipes of 13-3/8" – 9-5/8" (P 110 -N 80) casing combination, as well as two pieces of 5-5/8" thin wall (0.08 in wall thickness) −7" (P 110) and eight pieces of 7" – 5" (P 110 – C 95) casing combination. The cements used were of API Class G type, blast furnace slug cement, and API Class G type with silica flour. The paper describes the results obtained, discusses possible field applications, and presents equations for calculating the collapse strength of cemented pipe-in-pipe casing strings.
Detección molecular de agentes infecciosos de transmisión sexual en un grupo de hombres sintomáticos y su relación con la conducta sexual (2016)

Two or more infectious agents were detected in 50% of samples. U. urealyticum was found in 25%, meanwhile C. trachomatis and M. hominis were detected in 15%. VHS-1, VHS-2 andM. genitalium were detected only in 5%. HPV was found in all samples. The most frequent HPV genotypes were VPH 16, 11, 70. There were no statistical link found between sexual behavior and the studied microorganisms Conclusion: Infectious agents associated with STIs were detected in symptomatic men. HPV was the most frequent pathogen and it was detected in multiple genotypes. It is necessary to increase the sample size to associate significantly the sexual behavior with the results.
Lentivirus and foamy virus vectors: novel gene therapy tools (2001)

The aim of gene therapy is to modify the genetic material of living cells to achieve therapeutic benefit. Gene therapy involves the insertion of a functional gene into a cell, to replace an absent or defective gene, or to fight an infectious agent or a tumour. At present, a wide variety of somatic tissues are being explored for the introduction of foreign genes with a view towards treatment. A prime requirement for successful gene therapy is the sustained expression of the therapeutic gene without any adverse effect on the recipient. A highly desirable vector would be generated at high titres, integrate into target cells (including non-dividing cells) and have little or no associated immune reactions. Lentiviruses have the ability to infect dividing and non-dividing cells and, therefore, constitute ideal candidates for development of vectors for gene therapy. This review presents a description of available lentiviral vectors, including vector design, applications to disease treatment and safety considerations. In addition, general aspects of the biology of lentiviruses with relevance to vector development will be discussed. Recent investigations have revealed that foamy viruses, another group of retroviruses, are also capable of infecting non-dividing cells. Thus, foamy virus vectors are actively being developed in parallel to lentivirus vectors. This review will also include various aspects of the biology of foamy viruses with relevance to vector development.
Study of 4-Quinolone Antibiotics in Biological Samples by Short-Column Liquid Chromatography Coupled with Electrospray Ionization Tandem Mass Spectrometry (1997)

Simultaneous detection and confirmation of 15 quinolone antibiotics was accomplished by fast short-column liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC/MS/MS). Several physiochemical parameters such as hydrophobicity and aqueous dissociation constants were calculated from the structural formulas of the quinolone drugs, and their impact on both chromatographic and mass spectrometric behavior was studied. Additionally, a possible influence of bulk solution pH on electrospray detection sensitivity of 4-quinolones was investigated and compared to predictions based on solution-phase equilibria. A signal intensity comparison of the MH+ ions at different pH values for all 15 compounds did not reveal any pH effect, despite variations by several orders of magnitude in equilibrium concentrations in bulk solution. To demonstrate the potential of the LC/MS/MS method, its application to trace analysis in several biological matrices such as milk, salmon, and human urine was investigated. The method was shown to be sensitive with detection limits down to 1 ppb in both milk and salmon tissue. The versatility of the method was also exhibited by utilizing it for rapid identification of urinary metabolites of ciprofloxacin. Finally, a new complementary approach is described for confirmatory analyses of 4-quinolones by means of a quasi-MS/MS/MS technique involving in-source collision-induced dissociation. It is shown that LC/quasi-MS/MS/MS can significantly enhance structural information and, thus, the specificity of analysis for the investigated 4-quinolones.
Flow cytometric analysis and cytopathology of body cavity fluids. (1987)

A total of 75 samples of body cavity fluids from 71 patients were analyzed by both flow cytometry (FCM), to detect cells with an abnormal DNA content (aneuploidy), and by conventional cytopathology. Samples included 27 pleural fluids, 35 peritoneal fluids, 11 peritoneal washings and 2 pericardial fluids. For cytologic examination, the samples were prepared using standard techniques. Samples for FCM analysis were centrifuged and exposed to a hypotonic solution containing detergent and propidium iodide, a DNA intercalating fluorescent stain. Aneuploidy as well as cytologic malignancy were found in 17 samples. Forty-seven samples had normal DNA histograms by FCM and were also cytologically negative. Four samples suspicious by cytology but normal by FCM were from patients with renal-cell carcinoma (two samples from the same patient), endometrial adenocarcinoma without metastasis and chronic lymphocytic leukemia. Three samples abnormal by FCM but negative by cytology were from patients with ovarian cystadenoma, cirrhosis and uterine leiomyoma. FCM showed aneuploidy in four cytologically negative samples from patients with histologically proven malignancy (lymphoma, colonic adenocarcinoma, cervical squamous cell carcinoma, and endometrial adenosquamous carcinoma). Based on these results, FCM analysis combined with conventional cytopathology yielded 100% sensitivity, 100% predictive value of a negative result and 94% specificity. This rapid and quantitative FCM analysis of body cavity fluids can be a very useful adjunct to conventional diagnostic cytopathology.
Gravimeter design and operation (1937)

Abstract An elementary general discussion of gravimeters and a brief comparison of gravimeter with torsion balance are given. Details as to construction, accuracy, speed of operation and methods of making field observations are given for one type of instrument which is being widely used in geophysical exploration work.