gebhart/patrepeval huggingface dataset:
Pseudolapped orthogonal transform (1989)

The pseudo-LOT, a modified version of the lapped orthogonal transform (LOT), is introduced. It can be viewed as either a block transform with overlapping basis functions or a critically-sampled multirate filter bank with nearly perfect reconstruction. A fast algorithm for the pseudo-LOT, based on the discrete cosine transform, is presented.
A methenyl tetrahydromethanopterin cyclohydrolase and a methenyl tetrahydrofolate cyclohydrolase in <i>Methylobacterium extorquens</i> AM1 (1999)

Recently it was found that Methylobacterium extorquens AM1 contains both tetrahydromethanopterin (H4MPT) and tetrahydrofolate (H4F) as carriers of C1 units. In this paper we report that the aerobic methylotroph contains a methenyl H4MPT cyclohydrolase (0.9 U x mg-1 cell extract protein) and a methenyl H4F cyclohydrolase (0.23 U x mg-1). Both enzymes, which were specific for their substrates, were purified and characterized and the encoding genes identified via the N-terminal amino acid sequence. The purified methenyl H4MPT cyclohydrolase with a specific activity of 630 U x mg-1 (Vmax = 1500 U x mg-1; Km = 30 microm) was found to be composed of two identical subunits of molecular mass 33 kDa. Its sequence was approximately 40% identical to that of methenyl H4MPT cyclohydrolases from methanogenic archaea. The methenyl H4F cyclohydrolase with a specific activity of 100 U x mg-1 (Vmax = 330 U x mg-1; Km = 80 microm) was found to be composed of two identical subunits of molecular mass 22 kDa. Its sequence was not similar to that of methenyl H4MPT cyclohydrolases or to that of other methenyl H4F cyclohydrolases. Based on the specific activities in cell extract and from the growth properties of insertion mutants it is suggested that the methenyl H4MPT cyclohydrolase might have a catabolic, and the methenyl-H4F cyclohydrolase an anabolic function in the C1-unit metabolism of M. extorquens AM1.
Configuration, simulation and animation of manufacturing systems via the Internet (2002)

In the light of growing demand for individualized products, configuration systems are becoming increasingly important. Most interesting are configurators that can be accessed over the Internet. They can be used by sales representatives and customers independent of location and time. In this paper, a new electronic service for configuration, simulation and animation of manufacturing systems is considered. It allows to present, test and optimize manufacturing systems via the Internet.
Approximate string matching using withinword parallelism (1994)

Abstract Given a text string, a pattern string, and an integer k , the problem of approximate string matching with k differences is to find all substrings of the text string whose edit distance from the pattern string is less than k. The edit distance between two strings is defined as the minimum number of differences, where a difference can be a substitution, insertion, or deletion of a single character. An implementation of the dynamic programming algorithm for this problem is given that packs several characters and mod‐4 integers into a computer word. Thus, it is a parallelization of the conventional implementation that runs on ordinary processors. Since a small alphabet means that characters have short binary codes, the degree of parallelism is greatest for small alphabets and for processors with long words. For an alphabet of size 8 or smaller and a 64 bit processor, a 21‐fold parallelism over the conventional algorithm can be obtained. Empirical comparisons to the basic dynamic programming algorithm, to a version of Ukkonen's algorithm, to the algorithm of Galil and Park, and to a limited implementation of the Wu‐Manber algorithm are given.
Optic flow and depth perception (1993)

The field of depth recovery from optic flow has recently experienced much growth, both on the theoretical and on the empirical fronts. Unfortunately, the theoretical results are not as widely known to perception workers as they might be. This article gives a simple analysis of the information for depth present in optic flow. It also reviews the psychophysical results for depth recovery from motion. These results are discussed with reference to the theoretical analysis and to relevant computer algorithms for depth recovery.
A Study on Changes in Surface Chemistry during the Initial Stages of Electroless Ni(P) Deposition on Alumina (1993)

The formation of the interface between electrolessly deposited Ni(P) and an alumina substrate was examd. Prior to metalization, the substrate was cleaned, etched, and activated with Sn, Ag, and Pd-contg. solns. Changes in surface chem. due to these pretreatments were analyzed with x-ray fluorescence and static SIMS. TEM plan-view micrographs visualized the changes in surface structure during the pretreatments. The initial stages of metalization were measured on Si3N4 membrane model substrates. Cross-section TEM micrographs were made of a thin Ni(P) film on the alumina ceramic, showing a columnar Ni(P) structure, a thin interfacial layer, and an intimate interfacial contact. Possible consequences for initiation and adhesion are discussed. [on SciFinder (R)]
Pushing Nanoionics to the Limits: Charge Carrier Chemistry in Extremely Small Systems (2013)

Size effects in ionic systems are of extraordinary importance for ion transport as well as mass storage. This constitutes the field of nanoionics. Even though the impact of size can be manifold, the interfacial symmetry break and its consequence of carrier redistribution is to the fore. The contribution goes beyond the mesoscopic case, where any contribution of unperturbed bulk defect structure has disappeared, and extrapolates into the regime of atomistic sizes. Even though these extrapolations represent pure thought experiments, much can be learned from them. They refer to the transition of heterolayered systems to layered crystals, of composites to mixed crystals as well as of nanocrystalline state to the amorphous state. Resulting effects on thermodynamics, transport and storage are discussed.
THE UPTAKE OF LOCALLY APPLIED [6:7-3H]OESTRADIOL-17β BY THE VAGINA OF THE OVARIECTOMIZED MOUSE (1964)

SUMMARY Locally applied [6:7- 3 H]oestradiol was taken up rapidly by the vagina, at a rate similar to that of oestrone. Levels of radioactivity in the tissue reached their highest value 1–3 min. after application, and thereafter dropped slowly to reach 20% of the injected dose at 12 hr. This is in contrast to the behaviour of oestrone, the tissue levels of which fell rapidly over the first ½ hr. It is suggested that this difference accounts for the relative biological activity of the two hormones in the vagina, and results from varying affinities for receptor sites associated with the initiation of vaginal growth. Evidence is presented that oestrone, oestradiol and oestriol have a common site of action. Dimethylstilboestrol (DMS) converted the retention pattern of oestradiol to one resembling that of oestrone, and it is suggested that this involves blocking of receptor sites. The results are discussed in relation to the mode of action of oestrogens.
Point cloud based iterative segmentation technique for 3D plant phenotyping (2018)

The segmentation of 3D point clouds is an important prerequisite step for many plant phenotype and data analysis. One of the main challenges is high resolution 3D plant model segmentation. In this paper, we present an iteration based approach for 3D segmentation directly from the dense point clouds that are reconstructed from multi-view images. We extend the existing euclidean distance and spectral clustering (SC) algorithms and using iteration approach to segment the 3D point clouds into elementary shape units that could represent the plant organs (stems, branches, leaves, etc.). Such approach only requires the 3D coordinate data information. Experimental results show our approach can effectively segmented the obtained point cloud for various plant species.
Integrating Trust Profiles, Trust Negotiation, and Attribute Based Access Control (2017)

Access to sensitive information is traditionally achieved through an authentication and authorization process via a username/password combination to validate a user's identity that is stored within the system being accessed. This method creates delays before sensitive information can be obtained in the circumstance that the user's identity is previously unknown, due to necessary human intervention during the pre-registration process. To expedite the retrieval of sensitive information in time-critical situations, we propose a new model of trust negotiation that defines a new trust profile that contains a collection of credentials describing the user's access history. The new model of trust negotiation utilizes role-based and attribute-based access control as part of the new trust profile to model the sensitivity of information that is being requested, where access is governed by role and credentials captured in attributes. As a result of our work, an authorization system based on trust negotiation can examine the user's history in detail, decide whether to authorize the user, and add its own record of user access to the user's trust profile that can be utilized in future attempts at access at other locations.
Mesoporous BaTiO<sub>3</sub>@SBA-15 derived via solid state reaction and its excellent adsorption efficiency for the removal of hexavalent chromium from water (2014)

We report the synthesis of a barium-titanate/mesoporous silica nanocomposite material BaTiO3@SBA-15 via aerosol assisted solid state reaction using SBA-15 as a hard template. Hexavalent chromium is one of the most harmful contaminants of industrial waste-water. We have used BaTiO3@SBA-15 nanocomposite as an adsorbent for the removal of chromium(vi)-contaminated water and it showed an adsorption capacity of 98.2 wt% within only 40 min contact time in a batch reactor. This mesoporous composite has retained this excellent adsorption efficiency of hexavalent chromium for several repetitive cycles, suggesting its future potential for the remediation of water contaminated with Cr(vi).
NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report (2014)

NUP98/NSD1 has recently been reported in association with poor outcome in acute myeloid leukemia (AML). Previous studies also observed a high overlap between NUP98/NSD1 and FLT3/ITD, raising the question as to whether the reported poor outcome is due to NUP98/NSD1 or caused by the co-occurrence of these 2 genetic lesions. We aimed to determine the prognostic significance of NUP98/NSD1 in the context of FLT3/ITD AML. A total of 1421 patients enrolled in 5 consecutive Children's Oncology Group/Children's Cancer Group and SWOG trials were evaluated. NUP98/NSD1 was found in 15% of FLT3/ITD and 7% of cytogenetically normal (CN)-AML. Those with dual FLT3/ITD and NUP98/NSD1 (82% of NUP98/NSD1 patients) had a complete remission rate of 27% vs 69% in FLT3/ITD without NUP98/NSD1 (P < .001). The corresponding 3-year overall survival was 31% vs 48% (P = .011), respectively. In CN-AML, patients with concomitant NUP98/NSD1 and FLT3/ITD had a worse outcome than those harboring NUP98/NSD1 only. In multivariate analysis, the dual NUP98/NSD1 and FLT3/ITD remained an independent predictor of poor outcome, and NUP98/NSD1 without FLT3/ITD lost its prognostic significance. Our study demonstrates that it is the interaction between NUP98/NSD1 and FLT3/ITD that determines the poor outcome of patients with NUP98/NSD1 disease.
Scattering properties of needlelike and platelike ice spheroids with moderate size parameters (2000)

We use the current advanced version of the T-matrix method to compute the optical cross sections, the asymmetry parameter of the phase function, and the scattering matrix elements of ice spheroids with aspect ratios up to 20 and surface-equivalent-sphere size parameters up to 12. We demonstrate that platelike and needlelike particles with moderate size parameters possess unique scattering properties: their asymmetry parameters and phase functions are similar to those of surface-equivalent spheres, whereas all other elements of the scattering matrix are typical of particles much smaller than the wavelength (Rayleigh scatterers). This result may have important implications for optical particle sizing and remote sensing of the terrestrial and planetary atmospheres.
Ionization and current growth in an E B (1969)

The discharge buildup in a long Homopolar-type rotating device with mirror-shaped magnetic field was investigated by time-resolved measurements of the current and potential distributions, in combination with image- converter camera pictures. The ratio of cyclotron and collision frequency for electrons was much larger than unity, and the filling gases were H2, N2, He, Ne and Ar at 10-2torr. An exponential increase of the current was observed between 10-1 and 102 A, within a wide range of E/B. The rate of current growth in H2 could be compared with known values of the electron impact ionization rate in crossed fields. For the other gases it is shown that under certain experimental conditions ionization by positive ions can be important.
Efficient Synthesis of (3<i>R</i>,3a<i>S</i>,6a<i>R</i>)- Hexahydrofuro[2,3-<i>b</i>]furan-3-ol from Glycolaldehyde (2008)

A one-step diastereoselective (up to 98:2) synthesis of the bis-furan alcohol of Darunavir and other HIV drug candidates has been achieved utilizing the novel cyclization of glycolaldehyde and 2,3-dihydrofuran. The cycloaddition was catalyzed by a variety of catalysts including those formed from tin(II) triflate and common chiral ligands such as BINAP and Evans's box ligands. An efficient and unique enzymatic process enhanced the enantiomeric purity to provide the target in optically pure form.
Fabrication of depletion type micro-ring modulator with high extinction ratio and high coupling quality factor (2017)

We experimentally demonstrate an optical micro-ring modulator based on a reverse-biased PN junction which is integrated into a silicon-on-insulator (SOI) rib waveguide. The performance of micro-ring resonator with different sizes is simulated with Lumerical MODE Solutions. The fabricated device provides a high extinction ratio (ER) of 20 dB and coupling quality factor (Q) 2*104. Modulation rate is higher than 11 Gbit/s with only 2 V peak-to-peak (Vpp) driving voltage. The theoretical modulation rate can be higher than 25 Gbit/s by the optimizing the matching resistor and the test system.
Integration of Multiple Genomic and Phenotype Data to Infer Novel miRNA-Disease Associations (2016)

MicroRNAs (miRNAs) play an important role in the development and progression of human diseases. The identification of disease-associated miRNAs will be helpful for understanding the molecular mechanisms of diseases at the post-transcriptional level. Based on different types of genomic data sources, computational methods for miRNA-disease association prediction have been proposed. However, individual source of genomic data tends to be incomplete and noisy; therefore, the integration of various types of genomic data for inferring reliable miRNA-disease associations is urgently needed. In this study, we present a computational framework, CHNmiRD, for identifying miRNA-disease associations by integrating multiple genomic and phenotype data, including protein-protein interaction data, gene ontology data, experimentally verified miRNA-target relationships, disease phenotype information and known miRNA-disease connections. The performance of CHNmiRD was evaluated by experimentally verified miRNA-disease associations, which achieved an area under the ROC curve (AUC) of 0.834 for 5-fold cross-validation. In particular, CHNmiRD displayed excellent performance for diseases without any known related miRNAs. The results of case studies for three human diseases (glioblastoma, myocardial infarction and type 1 diabetes) showed that all of the top 10 ranked miRNAs having no known associations with these three diseases in existing miRNA-disease databases were directly or indirectly confirmed by our latest literature mining. All these results demonstrated the reliability and efficiency of CHNmiRD, and it is anticipated that CHNmiRD will serve as a powerful bioinformatics method for mining novel disease-related miRNAs and providing a new perspective into molecular mechanisms underlying human diseases at the post-transcriptional level. CHNmiRD is freely available at http://www.bio-bigdata.com/CHNmiRD.
Medically important arboviruses of the United States and Canada (1994)

Of more than 500 arboviruses recognized worldwide, 5 were first isolated in Canada and 58 were first isolated in the United States. Six of these viruses are human pathogens: western equine encephalitis (WEE) and eastern equine encephalitis (EEE) viruses (family Togaviridae, genus Alphavirus), St. Louis encephalitis (SLE) and Powassan (POW) viruses (Flaviviridae, Flavivirus), LaCrosse (LAC) virus (Bunyaviridae, Bunyavirus), and Colorado tick fever (CTF) virus (Reoviridae, Coltivirus). Their scientific histories, geographic distributions, virology, epidemiology, vectors, vertebrate hosts, transmission, pathogenesis, clinical and differential diagnoses, control, treatment, and laboratory diagnosis are reviewed. In addition, mention is made of the Venezuelan equine encephalitis (VEE) complex viruses (family Togaviridae, genus Alphavirus), which periodically cause human and equine disease in North America. WEE, EEE, and SLE viruses are transmitted by mosquitoes between birds; POW and CTF viruses, between wild mammals by ticks; LAC virus, between small mammals by mosquitoes; and VEE viruses, between small or large mammals by mosquitoes. Human infections are tangential to the natural cycle. Such infections range from rare to focal but are relatively frequent where they occur. Epidemics of WEE, EEE, VEE, and SLE viruses have been recorded at periodic intervals, but prevalence of infections with LAC and CTF viruses typically are constant, related to the degree of exposure to infected vectors. Infections with POW virus appear to be rare. Adequate diagnostic tools are available, but treatment is mainly supportive, and greater efforts at educating the public and the medical community are suggested if infections are to be prevented.
TUF, the yeast DNA-binding factor specific for UASrpg upstream activating sequences: identification of the protein and its DNA-binding domain. (1987)

The factor TUF interacts specifically with RPG or HOMOL1 sequences, which are present upstream of many genes coding for the yeast translational apparatus. Here we present evidence that the RPG and HOMOL1 motifs are variants of a consensus UASrpg (upstream activating sequence) recognized by the same factor. Factor TUF was identified by using two highly selective methods. The DNA-protein complex was isolated by pore-limit electrophoresis in polyacrylamide gradient gels and found to contain a single polypeptide of 150 kDa. In a two-step protein-blotting/nuclease-protection ("footprinting") procedure, the same 150-kDa polypeptide blotted on nitrocellulose exhibited the same specific DNA-binding properties as TUF factor. A 50-kDa DNA-binding domain of TUF was isolated by selective proteolysis. This suggests a bipolarization of the TUF protein, with distinct functional domains.
[Study of the positive effect of work and nature on various aspects of child development at the preschool age]. (2008)

The goal of this study consists in showing the positive effects of contact with nature, linked to some well structured activities, on some developmental aspects with 4 to 6 years old children. In a semi-structured setting children belonging to the experimental group had the opportunity to meet and explore spontaneously nature with all its aspects and to discover natural phenomena linked to evolution and life, mirroring some analogous principles of their own development. Nature functioned as a free space, offering multiple possibilities to play and explore freely, aside from any kind of evaluation and consideration based on priority. With regard to the complexity of the theme and the great amount of possible interconnections, a holistic approach was appropriate. With the help of a quasi-experimental design, we evaluated the data of two groups of children, analyzing not only their development, but also the relationships with their familiar environment and their involvement with nature. Thanks to three different procedural approaches, it was possible to show the differential progress of the experimental group in comparison with the control group, to select variables responsive to contact with nature and to bring out the positive link between good emotional contact with nature and general development.
Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab (2016)

Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab
Evaluation of the 2008 Lexus LS 600H Hybrid Synergy Drive System (2009)

Subsystems of the 2008 Lexus 600h hybrid electric vehicle (HEV) were studied and tested as part of an intensive benchmarking effort carried out to produce detailed information concerning the current state of nondomestic alternative vehicle technologies. Feedback provided by benchmarking efforts is particularly useful to partners of the Vehicle Technologies collaborative research program as it is essential in establishing reasonable yet challenging programmatic goals which facilitate development of competitive technologies. The competitive nature set forth by the Vehicle Technologies program not only promotes energy independence and economic stability, it also advocates the advancement of alternative vehicle technologies in an overall global perspective. These technologies greatly facilitate the potential to reduce dependency on depleting natural resources and mitigate harmful impacts of transportation upon the environment.
Effect of subconjuctival and intraocular bevacizumab injection on angiogenic gene expression levels in a mouse model of corneal neovascularization. (2009)

Bevacizumab treatment partially inhibits the progressive corneal neovascularization induced by chemical damage in a mouse model. Treatment is more effective when administered via the intraocular than the subconjunctival route. The clinical findings are compatible with the angiographic and histologic data and are supported by molecular analysis showing a partial change in expression of proangiogenic genes. The molecular mechanisms involved in corneal neovascularization and inflammation warrant further exploration. These findings may have important therapeutic implications in the clinical setting.
Characterization of µc-Si:H Prepared by Photo-Chemical Vapor Deposition (1986)

Microcrystalline silicon deposited by photo-CVD is characterized to reveal dependence of crystallinity on the film preparation conditions. The volume fraction of microcrystalline ( X c ) depends strongly on the dilution ratio of silane gas by hydrogen gas and substrate temperature ( T s ) of deposition, while the grain size (δ) of the microcrystalline is kept conslant irrespective of deposition condition. Preferred orientation changes from (110) to (111) with increasing X c .