gebhart/patrepeval huggingface dataset:
Java interface to human anatomy knowledge (2002)

The paper presents a novel Internet based application that provides access to anatomy knowledge through symbolic modality expressed by keywords taken from controlled or non-controlled terminology. The system is based on a database where anatomical concepts have been organized into a hierarchical framework. Along with term queries that allow retrieving concepts containing or exactly matching the used keyword, the system provides semantic access to anatomical information. Queries can be setup for retrieving concepts relying on a particular meaning and sharing particular relationships. Moreover, the application has the capability to refine the term search by automatically querying the UMLS Knowledge Server. Integration between symbolic and visual knowledge has been carried out by providing access to indexed image content. The system has been implemented through Java client-server technology and works within standard Internet browsers.
Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation (2011)

X-chromosome inactivation (XCI) results in the differential marking of the active and inactive X with epigenetic modifications including DNA methylation. Consistent with the previous studies showing that CpG island-containing promoters of genes subject to XCI are approximately 50% methylated in females and unmethylated in males while genes which escape XCI are unmethylated in both sexes; our chromosome-wide (Methylated DNA ImmunoPrecipitation) and promoter-targeted methylation analyses (Illumina Infinium HumanMethylation27 array) showed the largest methylation difference (D = 0.12, p < 2.2 E-16) between male and female blood at X-linked CpG islands promoters. We used the methylation differences between males and females to predict XCI statuses in blood and found that 81% had the same XCI status as previously determined using expression data. Most genes (83%) showed the same XCI status across tissues (blood, fetal: muscle, kidney and nerual); however, the methylation of a subset of genes predicted different XCI statuses in different tissues. Using previously published expression data the effect of transcription on gene-body methylation was investigated and while X-linked introns of highly expressed genes were more methylated than the introns of lowly expressed genes, exonic methylation did not differ based on expression level. We conclude that the XCI status predicted using methylation of X-linked promoters with CpG islands was usually the same as determined by expression analysis and that 12% of X-linked genes examined show tissue-specific XCI whereby a gene has a different XCI status in at least one of the four tissues examined.
Real Presence? (2012)

In a recent Chapter, Alexander Pruss attempts to defend the traditional Christian doctrine of Eucharistic Transubstantiation. It is objected that his case is unconvincing, since it involves accidents and dispositions existing without subjects, and an inadequate account of the Eucharistic presence of Christ. It is argued that the doctrine can yet be maintained, along Aristotelian-Thomistic lines.
Robotics and Virtual Reality: A Perfect Marriage for Motor Control Research and Rehabilitation (2006)

This article's goal is to outline the motivations, progress, and future objectives for the development of a state-of-the-art device that allows humans to visualize and feel synthetic objects superimposed on the physical world. The programming flexibility of these devices allows for a variety of scientific questions to be answered in psychology, neurophysiology, rehabilitation, haptics, and automatic control. The benefits are most probable in rehabilitation of brain-injured patients, for whom the costs are high, therapist time is limited, and repetitive practice of movements has been shown to be beneficial. Moreover, beyond simple therapy that guides, strengthens, or stretches, the technology affords a variety of exciting potential techniques that can combine our knowledge of the nervous system with the tireless, precise, and swift capabilities of a robot. Because this is a prototype, the system will also guide new experimental methods by probing the levels of quality that are necessary for future design cycles and related technology. Very important to the project is the early and intimate involvement of therapists and other clinicians in the design of software and its user interface. Inevitably, it should also lead the way to new modes of practice and to the commercialization of haptic/graphic systems.
Vision-Based Perception and Classification of Mosquitoes Using Support Vector Machine (2017)

The need for a novel automated mosquito perception and classification method is becoming increasingly essential in recent years, with steeply increasing number of mosquito-borne diseases and associated casualties. There exist remote sensing and GIS-based methods for mapping potential mosquito inhabitants and locations that are prone to mosquito-borne diseases, but these methods generally do not account for species-wise identification of mosquitoes in closed-perimeter regions. Traditional methods for mosquito classification involve highly manual processes requiring tedious sample collection and supervised laboratory analysis. In this research work, we present the design and experimental validation of an automated vision-based mosquito classification module that can deploy in closed-perimeter mosquito inhabitants. The module is capable of identifying mosquitoes from other bugs such as bees and flies by extracting the morphological features, followed by support vector machine-based classification. In addition, this paper presents the results of three variants of support vector machine classifier in the context of mosquito classification problem. This vision-based approach to the mosquito classification problem presents an efficient alternative to the conventional methods for mosquito surveillance, mapping and sample image collection. Experimental results involving classification between mosquitoes and a predefined set of other bugs using multiple classification strategies demonstrate the efficacy and validity of the proposed approach with a maximum recall of 98%.
A new scintillation-type time-of-flight anion detector (2001)

A new scintillation-type anion time-of-flight detector of high transmittance is reported. The precursor type of this detector, which is known as the Daly detector, is often used in molecular beam experiments in combination with time-of-flight mass spectrometry. We present an improved and simple design which has several advantages compared to most common anion detectors.
Keratinocyte Grafting: A New Means of Transplantation for Full‐Thickness Wounds (1988)

Twenty adult individuals with chronic leg ulcers caused by venous insufficiency, and 5 patients with full-thickness burns were treated. Twenty of the patients (15 with leg ulcers and 5 with burns) were grafted with separated autologous keratinocytes. In these cases the cells were fixed to the wound bed by a fibrin net. Five other patients (with leg ulcers) were treated with fibrin without keratinocytes. In 16 of the 20 patients grafted with keratinocytes in a fibrin net, the defect healed completely in 14 to 21 days. On the other hand, the fibrin net without keratinocytes failed to significantly accelerate the process of reepithelialization. Our experience suggests that a rapid healing of full-thickness skin defects can be achieved through keratinocyte grafting.
Insulin-regulated Glucose Uptake in Rat Adipocytes Is Mediated by Two Transporter Isoforms Present in at Least Two Vesicle Populations (1989)

We have recently described a monoclonal antibody (1F8) that recognizes a form of glucose transporter unique to fat and muscle (James, D. E., Brown, R., Navarro, J., and Pilch, P. F. (1988) Nature 333, 183-185), tissues that respond acutely to insulin by markedly increasing their glucose uptake. Here, we report that rat adipocytes possess two immunologically distinct glucose-transporters: one recognized by 1F8, and one reactive with antibodies raised against the human erythrocyte glucose transporter. Immunoadsorption experiments indicate that these glucose transporters reside in different vesicle populations and that both transporter isoforms translocate from intracellular sites to the plasma membrane in response to insulin. The insulin-regulatable transporter resides in a unique vesicle that comprises 3% or less of the low density microsomes of fat cells and has a limited protein composition that does not include the bulk of another translocatable protein, the insulin-like growth factor II receptor. Immunoprecipitation with 1F8 of microsomal glucose transporters photoaffinity labeled with [3H]cytochalasin B brings down 90% of the label. Similarly, immunoprecipitation with 1F8 of glucose transporters from insulin-stimulated plasma membranes photolabeled with 3-[125I]iodo-4-azidophenethylamido-7-O-succinyldeacetyl-f ors kolin, another transporter-selective reagent, results in 75% of the labeled transporter localized in the immunoprecipitate. Thus, insulin action involves the combined effect of translocation from at least two vesicle pools each containing different glucose transporters. The 1F8-reactive transporter comprises the majority of the total transporter pool that is responsible for the insulin-induced increase in glucose transporter number.
Characterization of heparin binding by a peptide from amyloid P component using capillary electrophoresis, surface plasmon resonance and isothermal titration calorimetry (2002)

Synthetic peptides based on amino-acid residues 27-38 of human serum amyloid P component represent a novel type of heparin binders as they do not contain clusters of basic amino acids or other known features associated with protein or peptide heparin binding. Here, we characterize the binding using capillary electrophoresis (CE), surface plasmon resonance (SPR), and isothermal titration calorimetry (ITC). By CE, heparin-binding activity was readily apparent for both a regular peptide and a slightly N-terminally modified form, while a sequence-scrambled peptide had no measurable binding. Dissociation constants in the 1-15 microm range were estimated, but only a minor part of the binding isotherm was covered by the experiments. SPR measurements using immobilized peptides verified heparin binding, the range of the binding constants, and the reduced binding of the sequence-scrambled peptide. Structurally defined heparin oligosaccharides were used to establish that while the tetrasaccharide is too small to exhibit strong binding, little difference in binding strength is observed between hexa- and tetradeca-saccharides. These experiments also confirmed the almost complete lack of activity of the sequence-scrambled peptide. The amino-acid sequence-dependent binding and the importance of a disulfide bond in the peptide were verified by ITC, but the experimental conditions had to be modified because of peptide precipitation and ITC yielded significantly weaker binding constants than the other methods. While the precise function of the peptide in the intact protein remains unclear, the results confirm the specificity of the glycosaminoglycan interaction with regard to peptide sequence by applying two additional biophysical techniques and showing that the N-terminal part of the peptide may be modified without changing the heparin binding capabilities.
The cellular inflammatory response in human spinal cords after injury (2006)

Spinal cord injury (SCI) provokes an inflammatory response that generates substantial secondary damage within the cord but also may contribute to its repair. Anti-inflammatory treatment of human SCI and its timing must be based on knowledge of the types of cells participating in the inflammatory response, the time after injury when they appear and then decrease in number, and the nature of their actions. Using post-mortem spinal cords, we evaluated the time course and distribution of pathological change, infiltrating neutrophils, monocytes/macrophages and lymphocytes, and microglial activation in injured spinal cords from patients who were 'dead at the scene' or who survived for intervals up to 1 year after SCI. SCI caused zones of pathological change, including areas of inflammation and necrosis in the acute cases, and cystic cavities with longer survival (Zone 1), mantles of less severe change, including axonal swellings, inflammation and Wallerian degeneration (Zone 2) and histologically intact areas (Zone 3). Zone 1 areas increased in size with time after injury whereas the overall injury (size of the Zones 1 and 2 combined) remained relatively constant from the time (1-3 days) when damage was first visible. The distribution of inflammatory cells correlated well with the location of Zone 1, and sometimes of Zone 2. Neutrophils, visualized by their expression of human neutrophil alpha-defensins (defensin), entered the spinal cord by haemorrhage or extravasation, were most numerous 1-3 days after SCI, and were detectable for up to 10 days after SCI. Significant numbers of activated CD68-immunoreactive ramified microglia and a few monocytes/macrophages were in injured tissue within 1-3 days of SCI. Activated microglia, a few monocytes/macrophages and numerous phagocytic macrophages were present for weeks to months after SCI. A few CD8(+) lymphocytes were in the injured cords throughout the sampling intervals. Expression by the inflammatory cells of the oxidative enzymes myeloperoxidase (MPO) and nicotinamide adenine dinucleotide phosphate oxidase (gp91(phox)), and of the pro-inflammatory matrix metalloproteinase (MMP)-9, was analysed to determine their potential to cause oxidative and proteolytic damage. Oxidative activity, inferred from MPO and gp91(phox) immunoreactivity, was primarily associated with neutrophils and activated microglia. Phagocytic macrophages had weak or no expression of MPO or gp91(phox). Only neutrophils expressed MMP-9. These data indicate that potentially destructive neutrophils and activated microglia, replete with oxidative and proteolytic enzymes, appear within the first few days of SCI, suggesting that anti-inflammatory 'neuroprotective' strategies should be directed at preventing early neutrophil influx and modifying microglial activation.
Real-Time Projector Tracking on Complex Geometry Using Ordinary Imagery (2007)

Using cameras to geometrically calibrate projector-based displays has been widely reported in the literature over the last decade. Most systems project structured-light patterns during a setup phase before starting the application in order to evaluate the geometric mapping from projector pixels to locations on the display surface. If this mapping changes e.g. the projector is moved, the application must be stopped and calibration re-initiated. Our pose estimation technique is based on detecting a set of image correspondences between the moving projector and a static camera using only the imagery displayed by the projector. We use an up-front calibration process to establish the geometry of the display surface, the pose of the camera, and the initial pose of the projector.
Pulsewidth Locked Loop (PWLL) for Automatic Resonant Frequency Tracking in LLC DC–DC Transformer (LLC -DCX) (2012)

In recently developed distributed power architecture, the LLC resonant converter has been widely used as a dc–dc transformer (DCX) to provide a semiregulated or unregulated bus voltage. In order to achieve the highest efficiency, this paper proposes a novel switching frequency control scheme for the LLC-DCX. First, the synchronous rectifier (SR) gate-driving signals are tuned by eliminating the body diode conduction. Then, the pulsewidth locked loop (PWLL) is presented, by minimizing the pulsewidth difference between the main switch and the well-tuned SR gate-driving signals, the LLC-DCX always runs at the <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$f_0$</tex> </formula> point to achieve the highest efficiency. For rapid prototyping purposes, the PWLL used to track <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$f_{0}$</tex></formula> is realized in a Cyclone III field programmable gate array.
Prognostics: a literature review (2016)

Integrated systems health management (ISHM) is an enabling technology used to preserve safe and reliable operation of complex engineering systems. It also helps in reducing processing and operation time, manpower and cost, and increasing system availability and utility. ISHM includes various technologies ranging from design, analysis, build, and verify to operate and maintain. Prognostics is one of the most challenging and beneficial aspects of ISHM. Knowledge of the remaining useful life using prognostics can make a significant paradigm shift in ISHM. Researchers that have new interest in prognostics need to read hundreds of articles to have a complete picture about prognostics and its relation to other disciplines. Our contribution to solving this problem is by introducing the first comprehensive vision about prognostics as a part of ISHM in a single literature review paper. We focus on prognostics benefits, approaches, applications, and challenges. This paper can be considered as the starting point for studying prognostics and health management.
Functional Metal Oxide Coatings by Molecule-Based Thermal and Plasma Chemical Vapor Deposition Techniques (2008)

Deposition of thin films through vaccum processes plays an important role in industrial processing of decorative and functional coatings. Many metal oxides have been prepared as thin films using different techniques, however obtaining compositionally uniform phases with a control over grain size and distribution remains an enduring challenge. The difficulties are largely related to complex compositions of functional oxide materials, which makes a control over kinetics of nucleation and growth processes rather difficult to control thus resulting in non-uniform material and inhomogeneous grain size distribution. Application of tailor-made molecular precursors in low pressure or plasma-enhanced chemical vapor deposition (CVD) techniques offers a viable solution for overcoming thermodynamic impediments involved in thin film growth. In this paper molecule-based CVD of functional coatings is demonstrated for iron oxide (Fe2O3, Fe3O4), vanadium oxide (V2O5, VO2) and hafnium oxide (HfO2) phases followed by the characterization of their microstructural, compositional and functional properties which support the advantages of chemical design in simplifying deposition processes and optimizing functional behavior.
Clinicopathological observations on metastasis in man studied in patients treated with peritoneovenous shunts. (1984)

Fourteen patients with inoperable cancer treated with peritoneovenous shunts for malignant ascites were studied post mortem. Clinical observations and findings at necropsy indicated that peritoneovenous shunting does not result in the establishment of clinically important haematogenous metastases and that metastases do not necessarily develop even when large numbers of viable tumour cells regularly enter the blood. Peritoneovenous shunting provides a unique opportunity for collecting data on the spread of tumours in man.
A role under scrutiny (2011)

Advanced practice is not subject to specific regulation in the UK, giving rise to concern about public safety.
Class-E DC/DC converters with a capacitive impedance inverter (1989)

Analysis and design rules are presented for three class-E switching-mode DC/DC power converters, each with a capacitive impedance inverter. Experimental results are given for one of the converters. A zero-voltage switching technique is achieved for both class-E inverters and rectifiers. Therefore, the efficiency of the converters is very high at switching frequencies in the megahertz range. By applying a capacitive impedance inverter, lossless operation of the class-E inverter can be obtained for a wide range of converter load resistance, from full load to infinity. Experimental results are in excellent agreement with the theoretical calculations. Only a 12% relative bandwidth of the switching frequency is required to maintain a constant DC output voltage for the load resistance from full load to infinity at about 1 MHz with 15-W output.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pre-clinical evaluation of new antiproliferative agents for the photochemotherapy of psoriasis: angelicin derivatives. (1981)

To have, before the clinical evaluation, sufficiently predictive information about the antiproliferative and phototoxic effect of new potential agents for the photochemotherapy of psoriasis some simple tests have been worked out. The antiproliferative activity was evaluated studying the inhibition of DNA synthesis first in Ehrlich ascites tumor cells, and then in mouse skin in vivo, both by topical application and oral administration. The phototoxicity was studied by topical application on guinea-pig skin, and for the most interesting compounds also in man. A group of angelicin derivatives, which can photoreact with DNA forming only monofunctional adducts, was submitted to this evaluation; a number of such compounds proved to be very active, practically as active as psoralen and 8-methoxypsoralen (8-MOP), two bifunctional furocoumarins capable of inducing both monofunctional adducts and inter-strand cross-links in DNA. Methylangelicins having a marked lipophilic character were only a little more active in inhibiting the epidermal DNA synthesis of mouse when given orally in comparison with topical application, while angelicin derivatives carrying a polar group at the 4' position in the furanic ring were not very active by topical application, but much more effective after systemic administration. These results can be explained supposing a different ability of compounds to penetrate into mouse skin by topical application and the presence of some pharmacokinetic and metabolic factors. Contrary to bifunctional furocoumarins, the angelicin derivatives studied proved to be non-phototoxic on the skin of guinea-pig and also on that of man.