gebhart/patrepeval huggingface dataset:
Dual Tunnelling Mechanism for Mobile IP Based 3G LTE-WLAN Handover (2008)

Mobile IPv6 (MIPv6) used to support IP mobility in heterogeneous network such as the universal mobile telecommunications system (or long term evolution system) and 802.11 wireless local area networks (WLANs). But MIPv6 has well-known packet loss during movement detection and binding update, but it has another packet loss while creating new tunnel and updating routing path. That is, when the home agent sends a binding acknowledgement (BA) message to mobile node after receiving a binding update (BU) message, the new tunneled packets are also sent to MN with the BA message. After receiving the BA message, the MN creates new tunnel and modifies routing information. But while completing these procedures, the MN can not handle new tunneled packets incoming together the BA message. To solve this problem, this paper proposes the dual tunneling mechanism(DTM) to reduce the additional loss using the reception- only tunnel. In this paper, we analyze the packet delay time in overlay and non-overlay network in case of general mobile IPv6 and DTM, and observe the handover experimental result for the 3G LTE-WLAN network.
SUMO-1 Modification and Its Role in Targeting the Ran GTPase-activating Protein, RanGAP1, to the Nuclear Pore Complex (1998)

RanGAP1 is the GTPase-activating protein for Ran, a small ras-like GTPase involved in regulating nucleocytoplasmic transport. In vertebrates, RanGAP1 is present in two forms: one that is cytoplasmic, and another that is concentrated at the cytoplasmic fibers of nuclear pore complexes (NPCs). The NPC-associated form of RanGAP1 is covalently modified by the small ubiquitin-like protein, SUMO-1, and we have recently proposed that SUMO-1 modification functions to target RanGAP1 to the NPC. Here, we identify the domain of RanGAP1 that specifies SUMO-1 modification and demonstrate that mutations in this domain that inhibit modification also inhibit targeting to the NPC. Targeting of a heterologous protein to the NPC depended on determinants specifying SUMO-1 modification and also on additional determinants in the COOH-terminal domain of RanGAP1. SUMO-1 modification and these additional determinants were found to specify interaction between the COOH-terminal domain of RanGAP1 and a region of the nucleoporin, Nup358, between Ran-binding domains three and four. Together, these findings indicate that SUMO-1 modification targets RanGAP1 to the NPC by exposing, or creating, a Nup358 binding site in the COOH-terminal domain of RanGAP1. Surprisingly, the COOH-terminal domain of RanGAP1 was also found to harbor a nuclear localization signal. This nuclear localization signal, and the presence of nine leucine-rich nuclear export signal motifs, suggests that RanGAP1 may shuttle between the nucleus and the cytoplasm.
Synthesis and Gastrointestinal Prokinetic Activity of Novel Benzamide Derivatives with Amphoteric Side Chains. (2001)

Novel benzamide derivatives (19-24, 32a-c, 43d-f), each possessing a cycloaminoalkanecarboxylic acid side chain, were synthesized and their gastrointestinal prokinetic and dopamine D2 receptor antagonist activities were evaluated. 4-[(4-Amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetic acid (19) exhibited the most potent gastro- and colon-prokinetic activities, through intravenous administration to conscious dogs, and also showed the reduced dopamine D2 receptor antagonistic activity. However, 19 showed only weak gastrointestinal prokinetic activity after oral administration. Several ester prodrugs (44-62) of 19 were tested for pharmacological activities as well as physicochemical and metabolic stability; the butyl ester (46) was consequently selected as a promising gastrointestinal prokinetic agent with reduced side effects.
Discriminative learning of additive noise and channel distortions for robust speech recognition (1998)

Learning the influence of additive noise and channel distortions from training data is an effective approach for robust speech recognition. Most of the previous methods are based on maximum likelihood estimation criterion. We propose a new method of discriminative learning environmental parameters, which is based on the minimum classification error (MCE) criterion. By using a simple classifier defined by ourselves and the generalized probabilistic descent (GPD) algorithm, we iteratively learn environmental parameters. After getting the parameters, we estimate the clean speech features from the observed speech features and then use the estimation of the clean speech features to train or test the back-end HMM classifier. The best error rate reduction of 32.1% is obtained, tested on a Korean 18 isolated confusion words task, relative to the conventional HMM system.
Tetrahydronaphthalenes:  Influence of Heterocyclic Substituents on Inhibition of Steroidogenic Enzymes P450 arom and P450 17 (1996)

In search of new leads for selective inhibition of estrogen and androgen biosynthesis, respectively, heterocyclic substituted 2-(arylmethylene)-1-tetralones (1-4, 9-17), 2-(aryl-hydroxymethyl)-1-tetralones (5-8), exo-1a,2,3,7b-tetrahydro-1H-cyclopropa[alpha] naphthalenes (18-24), and 3-alkyl substituted 4,5-dihydronaphtho[1,2-c]pyrazoles (25-27) were synthesized and tested for inhibitory activity toward four steroidogenic enzymes (P450 arom, P450 17, P450 18, and P450 scc, as well as another P450 enzyme, thromboxane A(2) (TXA(2)) synthase. The test compounds inhibited human placental P450 arom, showing a wide range of inhibitory potencies. (Z)-4-Imidazolyl compound 17 was the most potent inhibitor, with a relative potency (rp) of 110 [rp of aminoglutethimide (AG) = 1), rp of fadrozole = 359]. A competitive type of inhibition was shown by the (E)-4-imidazolyl compound 16(rp = 71). On the other hand some of these compounds inhibited rat testicular P450 17. Maximum activity was shown by the 3-pyridyl compound 20 (rp = 10, ro of ketoconazole = 1). 20 was the only compound which exhibited a marked inhibition of TXA(2) synthase (IC(50) = 14.5 microM; IC(50) of dazoxiben = 1.1 microM). Regarding selectivity toward the steroidogenic enzymes, compound 16 was relatively selective toward P450 arom, whereas compound 20 was relatively selective toward P450 17. (P450 arom: K(m) testosterone = 42 nM, K(i)16 = 33 nM, K(i)20 = 3 microM. P450 17: K(m)progesterone = 7 microM, K(i)16 = 9 microM, K(i)20 = 80 nM). 17 and 24 were not selective since they showed strong inhibition of P450 arom (K(i)17 = 26 nM, K(i)24 = 0.12 microM) and P450 17 (K(i) 17 = 0.7 microM, K(i)24 = 0.11 microM).
Spatial and temporal variation of rod photoreceptor reflectance in the human retina (2011)

Using adaptive optics imaging tools to image the living retina, numerous investigators have reported temporal fluctuation in the reflectivity of individual cone photoreceptors. In addition, there is cone-to-cone (spatial) variation in reflectivity. As it has only recently become possible to image the complete rod photoreceptor mosaic in the living human retina, we sought to characterize the reflectivity of individual rods and compare their behavior to that of foveal/parafoveal cones. Across two subjects, we were able to successfully track the reflectance behavior of 1,690 rods and 1,980 cones over 12 hours. Rod and cone photoreceptors showed similar regional and temporal variability in their reflectance profiles, suggesting the presence of a common governing physiological process. Within the rod and cone mosaics, there was no sign of spatial clumping of reflectance profile behavior; that is, the arrangement of cells of a given archetypal reflectance profile within the mosaic was indistinguishable from random. These data demonstrate the ability to track the behavior of rod reflectivity over time. Finally, as these and other reflectance changes may be an indicator of photoreceptor function, a future extension of this method will be to analyze this behavior in patients with rod photoreceptor dysfunction (e.g., retinitis pigmentosa, Usher's syndrome, and congenital stationary night blindness).
Seedling Growth of Intermountain Perennial and Weedy Annual Grasses (1998)

Squirreltail [Elymus elymoides (Raf.) Swezey] is a native cool-season grass that has been observed to invade rangelands dominated by the weedy annual grasses, cheatgrass (Bromus tectorum L.) and medusahead wildrye [Taeniatherum caput-medusae (L.) (Nevski]. Our objective was to determine if growth characteristics could account for this squirreltail trait. We used growth analysis to examine differences in seedling growth and tissue allocation of 5 squirreltail entries, 2 long-lived perennial grasses ('Goldar' bluebunch wheatgrass [Pseudoroegneria spicata (Pursh) A. Löve] and 'Hycrest' crested wheatgrass [Agropyron desertorum (Fisch. ex Link) Schult. X A. cristatum (L.) Gaertn.]), cheatgrass, and medusahead wildrye. We monitored the 9 entries in a greenhouse for mean relative growth rate, net assimilation rate, leaf area ratio, specific leaf area, leaf weight ratio, root relative growth rate, specific root length, root-to-shoot dry-mass ratio, and root length-to-leaf area ratio beginning 10 days after sowing at 9 destructive harvests at 3-day intervals. Cheatgrass had high relative growth rate for both shoot and root. Only medusahead wildrye equalled the shoot relative growth rate of cheatgrass, and only Hycrest equalled its root relative growth rate. Cheatgrass seedlings were larger than squirreltail seedlings by 2 to 3 weeks after emergence. Few differences were detected among perennials and medusahead wildrye. Cheatgrass displayed the highest leaf area ratio and specific leaf area of the 9 entries but was similar to medusahead wildrye and Red Deer River squirreltail for specific root length. Growth characteristics cannot account for squirreltail's observed ability to invade annual grass stands. However, the combination of high specific leaf area and specific root length in squirreltail germplasm, as found in cheatgrass, may enhance squirreltail survival under competition with annual grasses, especially medusahead wildrye.
High-rate anaerobic wastewater treatment under psychrophilic and thermophilic conditions (1997)

Anaerobic wastewater treatment is an attractive and generally accepted technology for the treatment of various types of medium- and high-strength wastewaters. So far, this treatment technology is mostly applied at the mesophilic temperature range between 25 and 40°C. However, results of recent research conducted under both psychrophilic (&lt; 20°C) and thermophilic (&gt; 45°C) conditions, reveal that temperature is not a limiting factor in applying anaerobic treatment, provided the appropriate process design is chosen. Temperature has a considerable impact on various biological and physical factors of the anaerobic conversion process. For instance, the biogas production rate is reduced to a minimum at low temperatures, while it can reach extreme values under thermophilic conditions. In sludge bed systems, the biogas production rate determines the degree of mixing between the biomass and the wastewater and should, therefore, be considered in the process design. Other impacts of temperature are related to inhibition effects under thermophilic conditions and to a non-desirable accumulation of non- or partly degradable organic matter under psychrophilic conditions. Obviously, these effects may hamper the utility of the commonly applied single stage reactor systems. However, by adapting the process design to the expected prevailing conditions inside the reactor, the loading potentials and overall stability of the anaerobic high-rate process may be distinctly improved.
Horseshoe crab coagulation factor B. A unique serine protease zymogen activated by cleavage of an Ile-Ile bond. (1993)

Horseshoe crab factor B is an intracellular serine protease zymogen involved in the bacterial endotoxin-responsive hemolymph coagulation cascade. cDNAs for factor B were isolated utilizing a polymerase chain reaction product using two primers derived from the partial amino acid sequence. The cloned cDNA of 1928 base pairs encoded 400 amino acid residues of factor B precursor. The first 23 amino acid residues constitute a presumed prepropeptide that may be processed by both a signal peptidase and a processing protease, similar to mammalian vitamin K-dependent protease precursors. The mature protein consists of 377 amino acids with a calculated molecular mass of 40,570 Da. The overall structure is highly homologous to that of limulus proclotting enzyme (35.9% identity), the substrate for active factor B in the cascade. Like the proclotting enzyme, mature factor B is composed of an amino-terminal "clip"-like domain and a carboxyl-terminal serine protease domain homologous to that of human plasma prekallikrein (36.5%). Internal sequences encode a unique activation peptide. Surprisingly, the cleavage sites of the zymogen factor B for activation by limulus active factor C were found to be an Arg-Ser and an Ile-Ile bond, the latter of which has not been found in any other protease zymogens. These cleavages result in the release of the activation peptide, which consists of 21 residues with a carboxyl-terminal isoleucine. These results indicate that the intracellular clotting system of the limulus hemocyte, like mammalian plasma clotting cascade, proceeds with the sequential activation of three serine protease zymogens: factor C, factor B, and proclotting enzyme.
Low-Profile Narrow-Frame Antenna for Seven-Band WWAN/LTE Smartphone Applications (2014)

A small-size low-profile narrow-frame antenna for seven-band WWAN/LTE operations in the internal smartphone applications is proposed. The greatest highlight of this proposed antenna is that its narrow edge has a width of only 5 mm, which is very novel for smartphone applications. Meanwhile, the proposed narrow-frame antenna has a small size of 5 × 40 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and a low profile of 3 mm above the circuit board, which makes it very promising for slim smartphone applications. The proposed antenna is capable of covering GSM850/900/DCS/PCS/UMTS 2100/LTE2300/2500 operating bands. Detailed design considerations of the proposed antenna are described, and both experimental and simulation results are also presented and discussed.
Visual determination of color differences using probit analysis: Phase II (1989)

This experiment was an extension of research begun by Alman, Berns, Snyder, and Larsen with the purpose of developing a large set of data on the perception of medium (industrial) size color difference. In the current phase of the research the same experimental procedures were followed. A total of 50 observers were asked to make pass-fail judgements of sample pairs in comparison to an anchor pair that was near neutral with a CIELAB color difference of 1.0 unit. Several pairs of various color differences were evaluated along 119 vector directions originating from 19 color centers nominally spaced in CIELAB. There was a total of 32,100 visual observations. The statistical method of probit analysis was used to determine the color difference along each vector that was perceptually equal to the anchor pair under a 6100K daylight simulator. The results of the current phase indicate that CIELAB color differences in the range from 0.78 to 5.11 are perceptually equal to the unit color difference of the anchor pair.
Layered Data Representation for Visual Simulation of Terrain Erosion (2001)

New data structure for visual simulation of 3D terrains is introduced. The representation is inspired by real geological measurements and presents good trade-off between commonly used inexpensive, but inaccurate, height fields and memory demanding voxel representation. The representation is based on horizontal stratified layers consisting of one material. The layers are captured in certain positions of the landscape. This representation is then discretized into a 2D array. We demonstrate that the classical algorithm simulating thermal erosion (F.K. Musgrave, 1989), can run on this representation and we can even simulate some new properties. The simulation has been done on artificial data as well as on real data from Mars.
Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity. (1991)

C.B-17 severe combined immune deficient (SCID) mice, which lack functional B and T lymphocytes, allow xenografts and, therefore, can be used to study the biology of human malignancies. Two different human B cell lymphoma cell lines, SU-DHL-4 and OCI-Ly8, which both harbor the t(14;18) chromosomal translocation, were injected into C.B-17 SCID mice. Mice injected intravenously or intraperitoneally developed tumors and died in a dose-dependent manner. The presence of tumor cells in various murine tissues could be demonstrated by a clonogenic tumor assay, staining of frozen sections with a monoclonal antibody (mAb) against a human B cell antigen (CD19), and with the polymerase chain reaction technique. A protocol using cytotoxic effector cells was developed and used to selectively deplete the tumor cells from bone marrow. These cells were developed by growing peripheral blood mononuclear cells in the presence of interferon gamma (IFN-gamma), anti-CD3 mAb, and interleukin 2 (IL-2). The timing of IFN-gamma treatment was critical and optimal if IFN-gamma was added before IL-2 treatment. The cells that were stimulated by IFN-gamma, followed by IL-2, could be expanded by treatment with a mAb directed against CD3. These cells could be further activated by IL-1, but not by tumor necrosis factor alpha. With this protocol, a tumor cell kill of 3 logs was obtained as measured by a clonogenic assay. Interestingly, despite their high cytotoxic activity against lymphoma cells, these cells had little toxicity against a subset of normal human hematopoietic precursor cells (granulocyte/macrophage colony-forming units). These cells were further tested by treating murine bone marrow contaminated with the human lymphoma cell line SU-DHL-4, and injecting these cells into SCID mice to assay for tumor growth in vivo. The animals injected with bone marrow contaminated with SU-DHL-4 cells had enhanced survival if the bone marrow was treated with the cytokine-induced killer cells before infusion. The SCID mouse provides a useful in vivo model for evaluation of new therapeutic approaches for lymphoma treatment. The cytokine-induced killer cells generated as described here could have an important impact on bone marrow purging for autologous bone marrow transplantation as well as for adoptive immunotherapy.
GFAP Gene Expression during Development of Astrocyte (1997)

Glial fibrillary acidic protein (GFAP) is expressed exclusively in astrocytes in the central nervous system. In order to characterize individual cultured cells in which the GFAP promoter is active and to identify the regulatory mechanisms of GFAP expression in these cells, we have developed a unique assay system for promoter activity using retrovirus vectors. Retrovirus containing the mouse GFAP promoter fused to the lacZ gene were used to infect mixed glial cultures. The infected cells, in which the GFAP promoter was active, were visualized by X-Gal staining. From these experiments, we found that a 256 bp fragment 5' of the transcription initiation site was sufficient to confer astrocyte-specific expression of GFAP. The GFAP promoter became active about 3 days before GFAP protein can be detected immunohistochemically, which indicates that detection of GFAP promoter activity can be used to identify astrocyte progenitors. We have also established immortalized astrocyte cell lines in which we detect GFAP promoter activity. Immorto mouse is a transgenic mouse generated by the introduction of thermolabile SV40 T Ag, tsA58. A mixed glial culture prepared from 2-day-old Immorto mouse brain was incubated at 32 degrees C, at which temperature most of the cells expressed T Ag. The culture was then infected with retrovirus containing GFAP promoter-lacZ, and the infected cells were selected. Using the fluorescence-activated cell sorter with fluorescein di-beta-D-galactopyranoside as a substrate (FDG-FACS), these cells were separated into two groups: FDG(+), in which the GFAP promoter was active, and FDG(-), in which it was inactive. Mature astrocyte cell lines were established from the FDG(+) cells by colony isolation. The FDG(-) cells were cloned by colony isolation and cultured at 32 or 39 degrees C. At the latter temperature the expression of T Ag was suppressed and cell differentiation was induced in most cells. The cells which became positive for X-Gal staining only after switching to 39 degrees C were collected as immature astrocyte cell lines. These immortalized cell lines should be useful to investigate the molecular mechanisms of astrocyte differentiation.
Broad-Band Isolators and Variable Attenuators for Millimeter Wavelengths (1961)

A longitudinally magnetized rod of ferrite has been used as a dielectric waveguide which provides Faraday rotation independent of frequency in the band from 50 to 60 kMc. This rotator has been incorporated into broad-band isolators with forward losses of 1 db and reverse losses greater than 30 db with return losses of approximately 20 db over the band. It has also been used in a variable attenuator with a minimum loss of 1 db and a maximum loss greater than 30 db which is essentially constant over the band. Advantages of this type of rotator at millimeter wavelengths include bandwidths in excess of 20 per cent, low field requirements (25-50 /spl oelig/), relatively large dimensions, the use of common ferrites, and the absence of conducting waveguide walls which permits rapid switching of the control field. The last feature has been utilized in an automatic power leveling system capable of removing variations of several kc frequency content from the swept output of a millimeter wave BWO.
Microprocessor-based data acquisition system for chemiluminescence measurements (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicroprocessor-based data acquisition system for chemiluminescence measurementsD. F. Marino and J. D. IngleCite this: Anal. Chem. 1981, 53, 8, 1175–1179Publication Date (Print):July 1, 1981Publication History Published online1 May 2002Published inissue 1 July 1981https://pubs.acs.org/doi/10.1021/ac00231a008https://doi.org/10.1021/ac00231a008research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts