gebhart/patrepeval huggingface dataset:
Long-term Storage of Metarhizium flavoviride Conidia in Oil Formulations for the Control of Locusts and Grasshoppers (1995)

Freshly harvested conidia of Metarhizium flavoviride (Gams & Rozsypal) were stored in two vegetable oils, groundnut or soya, or a mineral oil, Edelex. They were diluted with either Shellsol K or deodorized kerosene, and antioxidants were added to half of the vegetable oil formulations. Dried non-indicating silica gel was added to half of the formulations before storage at 8 or 17 C. Undried conidia, those without silica gel, lost viability rapidly, with germination dropping below 40% after 9 and 32 weeks at 17 and 8 C respectively. After 127 weeks (ca. 30 months) in storage, germination remained at over 60 and 80% for the dried formulations at 17 and 8 C respectively (after an unexplained drop in germination after 16-18 months in storage). Comparable figures for 160 weeks (ca. 37 months) were 47 and 68%. These figures represented germination after 24 h of incubation; after 48 h of incubation, germination was 79 and 89% from samples stored for 160 weeks at 17 and 8 C respectively. Representative formulations of the stored conidia were tested in bioassays against the desert locust Schistocerca gregaria (Forskal) up to 30 months into the experiment, and were found to have retained full virulence compared with freshly prepared formulations.
Propriospinal neurons are sufficient for bulbospinal transmission of the locomotor command signal in the neonatal rat spinal cord (2008)

We recently showed that propriospinal neurons contribute to bulbospinal activation of locomotor networks in the in vitro neonatal rat brainstem-spinal cord preparation. In the present study, we examined whether propriospinal neurons alone, in the absence of long direct bulbospinal transmission to the lumbar cord, can successfully mediate brainstem activation of the locomotor network. In the presence of staggered bilateral spinal cord hemisections, the brainstem was stimulated electrically while recording from lumbar ventral roots. The rostral hemisection was located between C1 and T3 and the contralateral caudal hemisection was located between T5 and mid-L1. Locomotor-like activity was evoked in 27% of the preparations, which included experiments with staggered hemisections placed only two segments apart. There was no relation between the likelihood of developing locomotor-like activity and the distance separating the two hemisections or specific level of the hemisections. In some experiments, where brainstem stimulation alone was ineffective, neurochemical excitation of propriospinal neurons (using 5-HT and NMDA) at concentrations subthreshold for producing locomotor-like activity, promoted locomotor-like activity in conjunction with brainstem stimulation. In other experiments, involving neither brainstem stimulation nor cord hemisections, the excitability of propriospinal neurons in the cervical and/or thoracic region was selectively enhanced by bath application of 5-HT and NMDA or elevation of bath K(+) concentration. These manipulations produced locomotor-like activity in the lumbar region. In total, the results suggest that propriospinal neurons are sufficient for transmission of descending locomotor command signals. This observation has implications for regeneration strategies aimed at restoration of locomotor function after spinal cord injury.
Sol-gel prepared β-Ga2O3 thin films for ultraviolet photodetectors (2007)

β - Ga 2 O 3 thin films have been prepared on (0001) sapphire substrates by the sol-gel method. X-ray diffraction showed that β-Ga2O3 polycrystalline films were formed at heat-treatment temperatures above 600°C. With increasing heat-treatment temperature above 900°C, the lattice constants of the β-Ga2O3 films decreased, while the band gap increased. Planar geometry photoconductive detectors based on the sol-gel prepared β-Ga2O3 thin films have been fabricated. They showed the photoresponse only for the wavelengths shorter than 270nm, which correspond to the solar-blind region. The peak wavelength in the spectral response depended on the heat-treatment temperature in the sol-gel process.
Magnetic Resonance Imaging Findings in Symptomatic Versus Asymptomatic Subjects Following Metal-on-Metal Hip Resurfacing Arthroplasty (2013)

An adverse synovial reaction was detected on MRI in both symptomatic and asymptomatic subjects. We found a larger volume of synovitis in symptomatic patients; this increase reached significance only in the group with an adverse local tissue reaction. Synovial volume on MRI may be a valuable marker in the longitudinal assessment of asymptomatic patients with a metal-on-metal hip resurfacing and in identifying patients with adverse local tissue reaction.
Spontaneous Cell Fusion in Macrophage Cultures Expressing High Levels of the P2Z/P2X7 Receptor (1997)

Mouse and human macrophages express a plasma membrane receptor for extracellular ATP named P2Z/P2X7. This molecule, recently cloned, is endowed with the intriguing property of forming an aqueous pore that allows transmembrane fluxes of hydrophylic molecules of molecular weight below 900. The physiological function of this receptor is unknown. In a previous study we reported experiments suggesting that the P2Z/P2X7 receptor is involved in the formation of macrophage-derived multinucleated giant cells (MGCs; Falzoni, S., M. Munerati, D. Ferrari, S. Spisani, S. Moretti, and F. Di Virgilio. 1995. J. Clin. Invest. 95:1207- 1216). We have selected several clones of mouse J774 macrophages that are characterized by either high or low expression of the P2Z/P2X7 receptor and named these clones P2Zhyper or P2Zhypo, respectively. P2Zhyper, but not P2Zhypo, cells grown to confluence in culture spontaneously fuse to form MGCs. As previously shown for human macrophages, fusion is inhibited by the P2Z/P2X7 blocker oxidized ATP. MGCs die shortly after fusion through a dramatic process of cytoplasmic sepimentation followed by fragmentation. These observations support our previous hypothesis that the P2Z/P2X7 receptor is involved in macrophage fusion.
Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay (1998)

Nitric oxide synthases (NOS) have a bidomain structure comprised of an N-terminal oxygenase domain and a C-terminal reductase domain. The oxygenase domain binds haem, (6R)-5,6,7,8-tetrahydro-l-biopterin (tetrahydrobiopterin) and arginine, is the site where nitric oxide synthesis takes place and contains determinants for dimeric interactions. A novel scintillation proximity assay has been established for equilibrium and kinetic measurements of substrate, inhibitor and cofactor binding to a recombinant N-terminal haem-binding domain of rat neuronal NOS (nNOS). Apparent Kd values for nNOS haem-domain-binding of arginine and Nomega-nitro-L-arginine (nitroarginine) were measured as 1.6 microM and 25 nM respectively. The kinetics of [3H]nitroarginine binding and dissociation yielded an association rate constant of 1.3x10(4) s-1.M-1 and a dissociation rate constant of 1.2x10(-4) s-1. These values are comparable to literature values obtained for full-length nNOS, suggesting that many characteristics of the arginine binding site of NOS are conserved in the haem-binding domain. Additionally, apparent Kd values were compared and were found to be similar for the inhibitors, L-NG-monomethylarginine, S-ethylisothiourea, N-iminoethyl-L-ornithine, imidazole, 7-nitroindazole and 1400W (N-[3-(aminomethyl) benzyl] acetamidine). [3H]Tetrahydrobiopterin bound to the nNOS haem domain with an apparent Kd of 20 nM. Binding was inhibited by 7-nitroindazole and stimulated by S-ethylisothiourea. The kinetics of interaction with tetrahydrobiopterin were complex, showing a triphasic binding process and a single off rate. An alternating catalytic site mechanism for NOS is proposed.
Combination therapy with VEGFR2 and EGFR siRNA enhances the antitumor effect of cisplatin in non-small cell lung cancer xenografts (2012)

RNA targeting the murine vascular endothelial growth factor receptor 2 (VEGFR2) gene was designed and validated for efficient and robust silencing in vitro and was delivered by polyethylenimines (PEI) in vivo to investigate the antitumor effect on non-small cell lung cancer (NSCLC) xenografts. The following dosage regimens were tested for their tumor inhibitory effect in vivo: VEGFR2 siRNA, epidermal growth factor receptor (EGFR) siRNA, VEGFR2 siRNA+EGFR siRNA, cisplatin alone and VEGFR2 siRNA+ EGFR siRNA+cisplatin. Targeted silencing of both VEGFR2 and EGFR expression by siRNA, combined with low-dose cisplatin, was found to effectively inhibit tumor growth and extend the survival time of mice bearing the NSCLC xenografts. These results suggest that combination therapy using siRNAs and chemotherapy agents might offer a novel strategy for cancer treatment in the future.
VACCINATION OF LAMBS AGAINST INFECTION WITH <i>TAENIA OVIS</i> (1976)

A trial was designed to test the efficacy of vaccination of lambs against field challenge with T. ovis eggs using 3 different levels of pasture contamination. Three concentric paddocks (1.62 hectares each) were used and the inner paddock was heavily contaminated with T. ovis eggs by tethering 2 dogs, experimentally infected with T. ovis, at 5 different points in the paddock over a period of 1 month. Four groups of lambs were used. Sixty lambs, from a property known to be free of T. ovis for 2 years previously, were divided into 2 groups of 30 each; one group was vaccinated with T. ovis culture antigen (vaccinated group=V) while the other was vaccinated with culture medium without antigen (sham-vaccinated group=SV). Thirty mature sheep were obtained from a property with a recent record of T. ovis infection (previous natural exposure to infection group=PNE) and 15 lambs were artificially reared from birth under cestode-egg-free conditions (artificially reared groups= AR). Ten animals from groups V, SV, and PNE, and 5 AR lambs were grazed on each of the 3 concentric paddocks for 6 weeks, and then all animals were slaughtered and their total muscle mass (including heart, diaphragm, tongue and masseters) examined, by slicing, for T. ovis cysticerci. The mean total numbers of T. ovis cysticerci recovered were as follows: Inner paddock, PNE 45.5, AR 47.6, SV 107.8, V 6.5; Middle paddock, PNE 5.2, AR 9.0, SV 8.2, V 0.3; Outer paddock, PNE 2.9, AR 2.8, SV 2.3, V 0.2. There were 4 major conclusions from this study. Firstly, vaccination was more effective than previous natural exposure to infection in preventing establishment of new cysticerci. Secondly, although vaccination effectively reduced the numbers of cysticerci, those that became established were mostly viable at the time of slaughter. In contrast, PNE sheep had greater numbers of cysticerci but the majority were degenerating. Vaccination, therefore, did not seem to stimulate a complete immunological response. Thirdly, the presence of T. hydatigena in lambs did not prevent subsequent infection with T. ovis. Fourthly, T. ovis eggs were dispersed from the inner paddock to the outer paddock.
Green organic synthesis dives into near-critical water (2000)

RETURN TO ISSUEPREVNewsNEXTGreen organic synthesis dives into near-critical waterPAMELA ZURERCite this: Chem. Eng. News 2000, 78, 1, 26–27Publication Date (Print):January 3, 2000Publication History Published online12 November 2010Published inissue 3 January 2000https://pubs.acs.org/doi/10.1021/cen-v078n001.p026https://doi.org/10.1021/cen-v078n001.p026newsACS PublicationsCopyright © 2000 AMERICAN CHEMICAL SOCIETYArticle Views12Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Chemical engineering and industrial chemistry,Organic compounds,Organic synthesis,Solvents,Wastes Get e-Alerts
Voltammetric and spectroelectrochemical studies of dodecamolybdophosphoric acid in aqueous and water-dioxane solutions at a gold-minigrid optically transparent thin-layer electrode (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVoltammetric and spectroelectrochemical studies of dodecamolybdophosphoric acid in aqueous and water-dioxane solutions at a gold-minigrid optically transparent thin-layer electrodeNobuyuki Tanaka, Kei Unoura, and Eiki ItabashiCite this: Inorg. Chem. 1982, 21, 4, 1662–1666Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://pubs.acs.org/doi/10.1021/ic00134a077https://doi.org/10.1021/ic00134a077research-articleACS PublicationsRequest reuse permissionsArticle Views288Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Probing the Kinetic Stabilities of Friedreich’s Ataxia Clinical Variants Using a Solid Phase GroEL Chaperonin Capture Platform (2014)

Numerous human diseases are caused by protein folding defects where the protein may become more susceptible to degradation or aggregation. Aberrant protein folding can affect the kinetic stability of the proteins even if these proteins appear to be soluble in vivo. Experimental discrimination between functional properly folded and misfolded nonfunctional conformers is not always straightforward at near physiological conditions. The differences in the kinetic behavior of two initially folded frataxin clinical variants were examined using a high affinity chaperonin kinetic trap approach at 25 °C. The kinetically stable wild type frataxin (FXN) shows no visible partitioning onto the chaperonin. In contrast, the clinical variants FXN-p.Asp122Tyr and FXN-p.Ile154Phe kinetically populate partial folded forms that tightly bind the GroEL chaperonin platform. The initially soluble FXN-p.Ile154Phe variant partitions onto GroEL more rapidly and is more kinetically liable. These differences in kinetic stability were confirmed using differential scanning fluorimetry. The kinetic and aggregation stability differences of these variants may lead to the distinct functional impairments described in Friedreich's ataxia, the neurodegenerative disease associated to frataxin functional deficiency. This chaperonin platform approach may be useful for identifying small molecule stabilizers since stabilizing ligands to frataxin variants should lead to a concomitant decrease in chaperonin binding.
LSTM-Based Zero-Velocity Detection for Robust Inertial Navigation (2018)

We present a method to improve the accuracy of a zero-velocity-aided inertial navigation system (INS) by replacing the standard zero-velocity detector with a long short-term memory (LSTM) neural network. While existing threshold-based zero-velocity detectors are not robust to varying motion types, our learned model accurately detects stationary periods of the inertial measurement unit (IMU) despite changes in the motion of the user. Upon detection, zero-velocity pseudo-measurements are fused with a dead reckoning motion model in an extended Kalman filter (EKF). We demonstrate that our LSTM-based zero-velocity detector, used within a zero-velocity-aided INS, improves zero-velocity detection during human localization tasks. Consequently, localization accuracy is also improved. Our system is evaluated on more than 7.5 km of indoor pedestrian locomotion data, acquired from five different subjects. We show that 3D positioning error is reduced by over 34% compared to existing fixed-threshold zero-velocity detectors for walking, running, and stair climbing motions. Additionally, we demonstrate how our learned zero-velocity detector operates effectively during crawling and ladder climbing. Our system is calibration-free (no careful threshold-tuning is required) and operates consistently with differing users, IMU placements, and shoe types, while being compatible with any generic zero-velocity-aided INS.
Properties SiOF Thin Films Deposited by ECR Plasma CVD (1997)

본 실험에서는 저유전율 층간절연물질로서 SiOF박막을 ECR plasma CVD를 이용하여 증착하였다. 또한 증착시에 발생시킨 플라즈마의 특성 분석을 위하여 Langmuir probe를 반응챔버에 부착하여 플라즈마 밀도, 마이크로파 전력은 700W, 기판온도는 30 $0^{\circ}C$ 에서 행하였다. 증착된 SiOF 박막을 분석한 결과, 가스유량비(SiF $_{4}$ /O $_{2}$ )가 0.2에서 1.6으로 증가하였을 때 불소의 함량은 약 5.3at%에서 14.5at%로 증가하였으며, 굴절률은 1.501에서 1.391로 감소하였고 이는 불소 첨가에 의한 박막의 밀도감소에 의한 것으로 생각된다. 또한 박막의 유전상수는 가스유량비가 1.0(11.8qt.% F함유)일 때 3.14였다.
Preschoolers + Computers = ABC: Computer Programming Abilities of Five-Year-Old Children. (1983)

1. The natriuretic effect of increasing doses of dopamine (1.5 to 15 x 10(-8) moles/kg/min intrarenally) was compared in dogs (pentobarbital anesthetized) who were either water restricted or overhydrated. 2. The dopaminergic response to doses larger than 1.5 x 10(-8) moles/kg/min (3 micrograms) was hidden either by important alpha-adrenergic effects or by renal reaction to the modifications in systemic haemodynamics. 3. Renal blood flow was increased by a dose of 1.5 x 10(-8) moles/kg/min of dopamine. At the same dose, natriuresis was increased only in hydrated dogs. Glomerular filtration rate only increased in water restricted animals. 4. The natriuretic effect of dopamine depended on the catecholamine induced variations of renal haemodynamic. 5. In water restricted animals, the absence of natriuretic effect of dopamine goes in hand with an absence of variation in filtration fraction. 6. In hydrated animals, the dopamine-induced natriuretic effect, in the absence of increased glomerular filtration, is tied to a decreased proximal tubular reabsorption of sodium probably secondary to the haemodynamic effects of this catecholamine.
Isoinertial tests to predict lifting performance. (1989)

Previous research has found isoinertial strength testing to be superior to isometric and isokinetic strength testing for prediction of task performance. The purpose of this study was to investigate tests on an isoinertial lifting machine (ILM) and their ability to predict performance on actual lifting tasks. Sixteen male subjects performed two lifting tasks: maximum box lift to truck-bed height of 1.35 m; and 'speed lifts' of 60 concrete blocks (each 22.7 kg) to the same height. These performance tests were compared to three ILM tests: a maximal lift to 1.83 m, a second maximal lift to 1.52 m, and an endurance test that entailed 60 timed ILM lifts of 22.7 kg to 1.83 m. Pearson product-moment correlations between ILM tests and performance tasks varied from r = 0.55 to 0.71. Therefore, the isoinertial test protocols employed in this study were able to account for only 30% to 50% of the variance in the performance of maximal lifting and endurance tasks. In was concluded that prediction of maximal lifting ability or endurance ability using an ILM might be enhanced by closer approximation of specific task variables, or by inclusion of dynamic parameters to measure technique.
Injecting Distributed Capabilities into Legacy Applications Through Cloning and Virtualization. (2000)

Copper surfaces exhibit high catalytic selectivity but have poor hydrogen dissociation kinetics; therefore, we consider icosahedral Cu<sub>13</sub> nanoclusters to understand how nanoscale structure might improve catalytic prospects. We find that the spin state is a surprisingly important design consideration. Cu<sub>13</sub> clusters have large magnetic moments due to finite size and symmetry effects and exhibit magnetization-dependent catalytic behavior. The most favorable transition state for hydrogen dissociation has a lower activation energy than that on single-crystal copper surfaces but requires a magnetization switch from 5 to 3 μ<sub>B</sub>. Without this switch, the activation energy is higher than that on single-crystal surfaces. Weak spin-orbit coupling hinders this switch, decreasing the kinetic rate of hydrogen dissociation by a factor of 16. We consider strategies to facilitate magnetization switches through optical excitations, substitution, charge states, and co-catalysts; these considerations demonstrate how control of magnetic properties could improve catalytic performance.
Genetic Background and Antibiotic Resistance of<i>Staphylococcus aureus</i>Strains Isolated in the Republic of Georgia (2006)

The genetic composition and antibiotic sensitivities of 50 clinical isolates of Staphylococcus aureus obtained from various clinics in the Republic of Georgia were characterized. S. aureus strains ATCC 700699 and ATCC 29737 were included as reference standards in all analyses. All 52 strains had identical 16S rRNA profiles. In contrast, pulsed-field gel electrophoresis (PFGE) identified 20 distinct PFGE types among the 52 strains examined, which indicates that PFGE is more discriminating than is 16S rRNA sequence analysis for differentiating S. aureus strains. The results of our PFGE typing also suggest that multiple genetic subpopulations (related at the ca. 85% similarity level, based on their SmaI PFGE patterns) exist among the Georgian S. aureus strains. Twenty-two of the 50 Georgian strains were methicillin resistant and PCR positive for mecA, and 5 strains were methicillin sensitive even though they possessed mecA. None of the strains were vancomycin resistant or contained vanA. The nucleotide sequences of mecA fragments obtained from all mecA-containing strains were identical. Our data indicate that the population of S. aureus strains in Georgia is fairly homogeneous and that the prevalence of methicillin-resistant, mecA-positive strains is relatively high in that country.
The Effect of High Temperature Ageing on Platinum-Rhodium and Palladium-Rhodium Three Way Catalysts (1991)

<div class="htmlview paragraph">The durability of platinum-rhodium and palladium-rhodium three way catalysts has been investigated after ageing at elevated temperatures. Catalysts were subjected to inlet temperatures of between 780 and 960 °C for periods up to 100 hours on an engine bench. It may be concluded that platinum-rhodium catalysts have a better resistance to ageing at catalyst inlet temperatures above 840 °C than palladium-rhodium catalysts at the same loading. A new formulation palladium-rhodium catalyst loaded at 60 g/ft3 and a ratio of 9:1 showed substantially improved high temperature durability.</div>