gebhart/patrepeval huggingface dataset:
Discovery of 5-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity (2013)

We synthesized 5-substituted pyrrolo[2,3-d]pyrimidine antifolates (compounds 5-10) with one-to-six bridge carbons and a benozyl ring in the side chain as antitumor agents. Compound 8 with a 4-carbon bridge was the most active analogue and potently inhibited proliferation of folate receptor (FR) α-expressing Chinese hamster ovary and KB human tumor cells. Growth inhibition was reversed completely or in part by excess folic acid, indicating that FRα is involved in cellular uptake, and resulted in S-phase accumulation and apoptosis. Antiproliferative effects of compound 8 toward KB cells were protected by excess adenosine but not thymidine, establishing de novo purine nucleotide biosynthesis as the targeted pathway. However, 5-aminoimidazole-4-carboxamide (AICA) protection was incomplete, suggesting inhibition of both AICA ribonucleotide formyltransferase (AICARFTase) and glycinamide ribonucleotide formyltransferase (GARFTase). Inhibition of GARFTase and AICARFTase by compound 8 was confirmed by cellular metabolic assays and resulted in ATP pool depletion. To our knowledge, this is the first example of an antifolate that acts as a dual inhibitor of GARFTase and AICARFTase as its principal mechanism of action.
Molecular cloning of the c-fms locus and its assignment to human chromosome 5 (1983)

Molecular clones of the retroviral oncogene v-fms were used to isolate recombinant bacteriophages containing c-fms proto-oncogene sequences from a human placental DNA library. Viral and cellular fms sequences were used in Southern blotting experiments with a panel of 32 human X mouse somatic cell hybrids to assign the human c-fms proto-oncogene to human chromosome 5.
Credit Card Fraud Detection using Deep Learning based on Auto-Encoder and Restricted Boltzmann Machine (2018)

Frauds have no constant patterns. They always change their behavior; so, we need to use an unsupervised learning. Fraudsters learn about new technology that allows them to execute frauds through online transactions. Fraudsters assume the regular behavior of consumers, and fraud patterns change fast. So, fraud detection systems need to detect online transactions by using unsupervised learning, because some fraudsters commit frauds once through online mediums and then switch to other techniques. This paper aims to 1) focus on fraud cases that cannot be detected based on previous history or supervised learning, 2) create a model of deep Auto-encoder and restricted Boltzmann machine (RBM) that can reconstruct normal transactions to find anomalies from normal patterns. The proposed deep learning based on auto-encoder (AE) is an unsupervised learning algorithm that applies backpropagation by setting the inputs equal to the outputs. The RBM has two layers, the input layer (visible) and hidden layer. In this research, we use the Tensorflow library from Google to implement AE, RBM, and H2O by using deep learning. The results show the mean squared error, root mean squared error, and area under curve.
Sentry (2010)

Light-weight, flexible access control, which allows software to regulate reads and writes to any granularity of memory region, can help improve the reliability of today's multi-module multi-programmer applications, as well as the efficiency of software debugging tools. Unfortunately, access control in today's processors is tied to support for virtual memory, making its use both heavy weight and coarse grain. In this paper, we propose Sentry, an auxiliary level of virtual memory tagging that is entirely subordinate to existing virtual memory-based protection mechanisms and can be manipulated at the user level. We implement these tags in a complexity-effective manner using an M-cache (metadata cache) structure that only intervenes on L1 misses, thereby minimizing changes to the processor core. Existing cache coherence states are repurposed to implicitly validate permissions for L1 hits. Sentry achieves its goal of flexible and light-weight access control without disrupting existing inter-application protection, sidestepping the challenges associated with adding a new protection framework to an existing operating system. We illustrate the benefits of our design point using 1) an Apache-based web server that uses the M-cache to enforce protection boundaries among its modules and 2) a watchpoint-based tool to demonstrate low-overhead debugging. Protection is achieved with very few changes to the source code, no changes to the programming model, minimal modifications to the operating system, and with low overhead incurred only when accessing memory regions for which the additional level of access control is enabled.
L’archaïsme, trait lexical du parler français de Belgique: Archaïsmes latéraux et archaïsmes verticaux (2000)

Faculté des Lettres. Centre international de recherche en aménagement linguistique
A mystery unraveled: nontumorigenic pluripotent stem cells in human adult tissues (2014)

Muse cells derived from adipose tissue (Muse-AT) are efficiently, routinely and painlessly isolated from human lipoaspirate material, exhibit tripoblastic differentiation both spontaneously and under media-specific induction, and do not form teratomas. We describe qualities specific to Muse-AT cells and their potential impact on the field of regenerative medicine and cell therapy.
Unsupervised Learning for Real-World Super-Resolution (2019)

Most current super-resolution methods rely on low and high resolution image pairs to train a network in a fully supervised manner. However, such image pairs are not available in real-world applications. Instead of directly addressing this problem, most works employ the popular bicubic downsampling strategy to artificially generate a corresponding low resolution image. Unfortunately, this strategy introduces significant artifacts, removing natural sensor noise and other real-world characteristics. Super-resolution networks trained on such bicubic images therefore struggle to generalize to natural images. In this work, we propose an unsupervised approach for image super-resolution. Given only unpaired data, we learn to invert the effects of bicubic downsampling in order to restore the natural image characteristics present in the data. This allows us to generate realistic image pairs, faithfully reflecting the distribution of real-world images. Our super-resolution network can therefore be trained with direct pixel-wise supervision in the high resolution domain, while robustly generalizing to real input. We demonstrate the effectiveness of our approach in quantitative and qualitative experiments.
Designing dynamic interactive visualisations to support collaboration and cognition (2003)

Dynamic interactive visualisations (DIVs) are intended to help coordination and collaboration, through augmenting existing forms of synchronous communication (i.e. phones, face to face, walkie-talkie). A central feature of a DIV is active user involvement: users are required to create, annotate, and change the information visualisation to represent the changes in the activity space they are concerned with. One benefit of doing so is to enable users to externalise and offload some of the cognitive effort involved. in problem-solving, by laying out information in ways that can help them derive a solution and know what to do next. In this paper we describe how we went about designing a DIV to support nomadic team working. We begin by describing our experimentation in designing a DIV. We then show how our computer-based DIV substantially, improved performance for a complex collaborative task, which involved much communication and cognition.
Membrane proximal cleavage of L-selectin: identification of the cleavage site and a 6-kD transmembrane peptide fragment of L-selectin. (1994)

Rapid downregulation of L-selectin expression occurs in response to leukocyte activation, and it has been speculated to be an integral process in the adhesion cascade leading to neutrophil recruitment to sites of inflammation. It has previously been proposed that L-selectin is proteolytically cleaved from the cell surface; however, the nature of the cleavage site has been unknown. We have produced polyclonal antisera against the extracellular domain and against the cytoplasmic domain of L-selectin. Both antisera immunoprecipitate the intact form of L-selectin from metabolically labeled phytohemagglutinin-stimulated lymphoblasts and peripheral blood neutrophils. In addition, the anti-cytoplasmic domain serum, but not the antiectodomain serum, immunoprecipitate a 6-kD species from PMA activated lymphoblasts and formylmethionylleucylphenylalanine-activated neutrophils. Conversely, the antiectodomain serum but not the anti-cytoplasmic domain serum immunoprecipitate a 68-kD soluble form of L-selectin from the supernatant of PMA-activated lymphoblasts. The appearance of the 6-kD species on activated cells correlated with the disappearance of the intact form of L-selectin and the appearance of the soluble form of L-selectin. A third polyclonal serum generated against the membrane proximal region of the ectodomain also reacted with the 6-kD species, indicating that this is a transmembrane peptide of L-selectin. That the 6-kD species is derived from L-selectin was confirmed by immunoprecipitation of the 6-kD species from L-selectin transfectants but not from mock transfectants. Radiochemical sequence analysis defined a cleavage site between Lys321 and Ser322, which would predict a transmembrane fragment consistent in size with the observed 6-kD fragment. A Ser-Phe-Ser motif adjacent to the cleavage site is conserved between human, mouse, and rat L-selectin, and a related motif is found proximal to transmembrane domains of other downregulated proteins, such as ACE, CD16-II, and TNF-RII, suggesting the possibility of a common recognition motif.
Turning your video monitor into a virtual window (2002)

A video conference system that allows a video attendee to look around an entire conference room simply by moving his or her head is described. In order to locate the attendee's head, a differential image is produced by removing a reference view from the current video image. The orientation of a motorized camera is then determined directly by the head position of the video attendee. The increased affordances of this mechanism are discussed.
Secret Sharing Schemes With General Access Structure Based On MSPs (2007)

In this paper we introduce two operations of access structure to build large monotone span programsMSPs from small MSPs. Furthermore, we point out a new method of constructing secret sharing schemes realizing any access structure, using MSPs.
Robust Model Predictive Control for Autonomous Driving (2017)

Autonomous driving is becoming popular nowadays. In order for autonomouscars to be fully accepted, high demands are placed on the safety side. Onesafety critical issue is the robustness to disturbances. In this work, a robustmodel predictive controller is designed for an autonomous vehicle. More specifically,robust output feedback model predictive control (ROFMPC) is used, androbustness is guaranteed through the use of robust invariant sets. The vehicleis modeled using a discretized, and linearized, version of a simple kinematicbicycle model, expressed in road-aligned coordinates. It is investigated for howlarge uncertainties robustness, and stability, can be guaranteed. Both externaldisturbances and measurement noise are considered. A steady-state Kalmanfilter is used to estimate the state of the vehicle. Two cases have been studiedin simulation; straight line and curved line trajectory following. Results fromsimulations show that robustness can be ensured if the uncertainties in the systemare sufficiently small. Finally, the ROFMPC algorithm is implemented onan F1/10 RC car.
Utility of the Ultrasound Elastographic Systolic Thyroid Stiffness Index in Reducing Fine-Needle Aspirations (2010)

Thyroid ultrasound elastography has the potential to substantially reduce the number of FNA biopsies by detecting type I benign nodules. Patients with suspicious type II nodules would be referred for an FNA. Future prospective studies are needed to confirm the efficacy of thyroid ultrasound elastography as a triage tool to FNA.
<i>Ab initio</i>calculations on the defect structure of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>β</mml:mi></mml:math>-Ga<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mrow/><mml:mn>2</mml:mn></mml:msub></mml:math>O<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mrow/><mml:mn>3</mml:mn></mml:msub></mml:math> (2013)

The intrinsic point defects of $\ensuremath{\beta}$-${\mathrm{Ga}}_{2}{\mathrm{O}}_{3}$ are investigated using density functional theory. We have chosen two different exchange-correlation potentials: the generalized gradient approximation (GGA) and a hybrid potential (HSE06). Defect formation energies were determined taking into account finite-size effects. Schottky, anti-Frenkel, and Frenkel energies have been extracted for $T=0$ K. We calculate formation entropies for an oxygen and a gallium vacancy and determine the Gibbs energy of Schottky disorder. Furthermore, we investigate the defect concentrations as a function of the oxygen partial pressure. The obtained purely intrinsic defect concentrations for charged defects are very small and result in a $p{\mathrm{O}}_{2}$ dependence of the electron concentration of $[{\mathrm{e}}^{\ensuremath{'}}]\ensuremath{\sim}$ $p{\mathrm{O}}_{2}^{\ensuremath{-}1/6}$, whereas experimentally $[{\mathrm{e}}^{\ensuremath{'}}]\ensuremath{\sim}$ $p{\mathrm{O}}_{2}^{\ensuremath{-}1/4}$ is found. So we assume that, experimentally, a small unintentional donor doping is unavoidable. A small extrinsic donor concentration $[{\mathrm{D}}^{\ifmmode\cdot\else\textperiodcentered\fi{}}]$ $=$ 10${}^{18}$ cm${}^{\ensuremath{-}3}$ (10 ppm) changes the electron concentration to $[{\mathrm{e}}^{\ensuremath{'}}]\ensuremath{\sim}$ $p{\mathrm{O}}_{2}^{\ensuremath{-}1/4}$ and gives an activation energy of the conductivity $\ensuremath{\sigma}$ of 1.7 eV in good agreement to experimental values. So we propose as majority disorder $3[{\mathrm{V}}_{\mathrm{Ga}}^{\ensuremath{'}\ensuremath{'}\ensuremath{'}}]$ $=$ $[{\mathrm{D}}^{\ifmmode\cdot\else\textperiodcentered\fi{}}]$ with electrons being minority defects.
Passive sensitization of monkey lung fragments with sera of timothy-sensitive patients. I. Spectrofluorometric analysis of histamine release. (1968)

Summary A spectrofluorometric method for the determination of histamine liberated from monkey lung tissue passively sensitized with human atopic sera is described. The close correlation of histamine liberated from sensitized tissue with P-K titer, the loss of activity by heating sera at 56°C for 1 hr, and the failure of both rabbit and rhesus monkey precipitating antibody or human blocking antibody to release histamine indicate that this method provides an in vitro estimation of the reagin content of the sera from allergic patients. The sensitivity of the method described may also permit the detection of reagin in the sera of allergic patients not detectable by the P-K test. It is suggested that the use of adult monkey lung tissue may provide a means to study the mechanism of antibody fixation.
The Endothelial Glycocalyx Protects Against Myocardial Edema (2003)

Myocardial tissue edema attributable to increased microvascular fluid loss contributes to cardiac dysfunction after myocardial ischemia, cardiopulmonary bypass, hypertension, and sepsis. Recent studies suggest that carbohydrate structures on the luminal surface of microvascular endothelium are essential to prevent tissue edema. We carefully preserved these structures for visualization with electron microscopy, revealing that the rat myocardial capillary endothelial surface is coated with a 0.2- to 0.5-microm-thick carbohydrate layer and that its degradation instantly results in notable myocardial tissue edema.
<title>Dynamics Of Pit Formation In Ablative Optical Recording</title> (1983)

A perspective on the evolution of ablative optical recording media is presented. The factors which lead to the development of efficient recording media and the mechanisms which govern pit formation are reviewed. Methods for monitoring pit formation in real time by reflection and transmission are described.
Fully Differential Difference Amplifier for Low-Noise and Low-Distortion Applications (2015)

In this paper, a fully differential difference amplifier (FDDA) designed in 0.35[Formula: see text][Formula: see text]m CMOS technology is presented. The proposed amplifier reaches high dynamic range (DR) and low input referred noise. Comparison of noise performance of the proposed FDDA to an ordinary differential amplifier has been performed. Achieved results prove that the developed amplifier circuit can be advantageously used in applications that require a fully differential signal. Then, simulation results have been verified by the measurement of prototyped chips. In our work, the proposed amplifier was experimentally employed in the analog frontend of the readout interface (RI) for a Micro-Electro-Mechanical-Systems (MEMS) capacitive microphone.
Synthesis and properties of alternating poly(Lys‐Phe) and comparison with the random copolymer poly(Lys<sup>51</sup>, Phe<sup>49</sup>) (1974)

Abstract The alternating copolypeptide poly(Lys‐Phe) was obtained by synthesis and polymerization of the respective tetrapeptide. Conformation and conformational transitions in aqueous solutions and in water–organic solvent mixtures were determined and compared with those of the random copolymer poly(Lys 51 ,Phe 49 ) by circular dichroism measurements. The alternating copolymer reveals a very strong tendency to adopt the β structure, which is accomplished by raising the pH or by adding sodium perchlorate or methanol. Partial α‐helical conformation, however, is obtained in the presence of 10–20% of the strong helix‐forming solvent hexafluoroisopropanol. The random copolymer reveals a much weaker preference for the β structure. It assumes the α helix in mixtures of water with hexafluoroisopropanol and also in those with methanol. As was already reported by Peggion et al. and confirmed by the present work, the addition of sodium perchlorate also leads to the helix conformation [(1972) Biopolymers 11 , 633], whereas β structure is obtained by raising the pH [(1970) Macromolecules 3 , 194]. These studies reveal the significance of affinities determined by near neighbor interactions in polypeptides.
Multi-Sensor Fusion for Mono and Multi-Vehicle Localization using Bayesian Network (2008)

This article has presented a multi-sensor fusion method for vehicle localization. The main contributions of this work are the formalization of a multi-sensor fusion method in the Bayesian Network context and an experimental validation with real data. An interesting characteristic of this approach is that it is flexible and modular in the sense that it can easily integrate other sensors. This feature is interesting because adding other sensors is a way to increase the robustness of the localization. In this approach, the use of the digital map as an observation of the state space representation has been introduced. This observation is used in the Bayesian Network framework in the same way that the GPS measurement. It turned out in the experiments that the GPS measurements are not necessary all the time, since the merging of odometry and roadmap data can provide a good estimation of the position over a substantial period. The strategy presented in this paper doesn't keep only the most likely segment. When approaching an intersection, several roads can be good candidates for this reason we manage several hypotheses until the situation becomes unambiguous. Multi-vehicle localization method presented in this work can be seen like an extension of the Mono-vehicle method, in the sense that we have duplicate the (BN) used to fuse
EmailCorrelation And Analysis Using Pattern Matching Technique (2018)

Email or Electronic mail is been widely used to exchange messages between people.Electronic mail or an Email can be personal, commercial, business related messages.These messages can be used to determine association between mail holders.A report or summary can be made by retrieving mails and grouping them to get a count of total mails that has been exchanged from a particular mail id.This will help to find out an association between the two contacts and reduces the burden of reading and going through each and every mail which is being send or received.The generated report is useful in means of cyber forensics and in means of data mining, where emails are studied to find out a person, company or an organization with whom the user has been communicating using emails and how many times they have exchanged emails.Proposed system generates a report on number of mail's being exchanged with different user and provides a graphical representation of the same.In addition, to the above feature, an advanced features is added in the system which helps to monitor the workers or group members and gets feedback on progress of work assigned to them by using emails.
The Co-Morbidity Burden of Children and Young Adults with Autism Spectrum Disorders (2012)

The comorbidities of ASD encompass disease states that are significantly overrepresented in ASD with respect to even the patient populations of tertiary health centers. This burden of comorbidities goes well beyond those routinely managed in developmental medicine centers and requires broad multidisciplinary management that payors and providers will have to plan for.
Reverse osmosis concentration of orange juice using spiral wound membranes (2005)

Flavor and odor components of foods are often lost during processing which leads to a poorer quality final product compared with the fresh ingredients. The orange juice industry concentrates juice (45-66oBrix) in TASTE (Thermally Accelerated Short Time Evaporator) to remove excess water, and thus reduce storage and transportation costs, but also to improve product stability. Evaporation results in a loss of fresh juice flavors, color degradation and “cooked” taste due to the thermal effects. Methods using less heat for thermal damage reduction must be investigated to establish parameters for future commercial processes. The promising alternative is Reverse Osmosis (RO), but it cannot achieve concentrations greater than 30oBrix. RO has advantages over traditional evaporation techniques in removing water. Because less heat is used, thermal damage to products is generally eliminated. In this project tests were performed using unpasteurised Single Strength Orange Juice (SSOJ), spiral wound membranes (Polyamide), and a DESAL pilot system model 4040. The aim was to evaluate spiral wound membranes on the basis of flux as a function of time. Retentate concentrations were 15-20oBrix, and GC-FID analyses were used in order to understand aroma losses.

KEYWORDS: Orange; juice; membrane; concentration; osmosis; reverse.