gebhart/patrepeval huggingface dataset:
Offset-dependent mis-tie analysis at seismic line intersections (1989)

Abstract Offset-dependent line-intersection displays can be of significant direct interpretive value. On our data set from a proprietary location, use of these displays permits a refined structural interpretation and improves the usefulness of amplitude and amplitude-versus-offset displays for direct hydrocarbon detection. The degree of data reproducibility at each intersection may be exposed as a function of offset through the use of prestack and partial-range stack splice and difference displays.At a set of marine line intersections, after only cursory processing, the range of residual amplitudes found by subtracting strike traces from dip traces is from -20 dB to +6 dB relative to the input. The average is about -8 dB. The poorest line intersection ties occur below the edges of deep bright spots, where velocity anomalies leading to time mis-ties greater than 10 ms can occur. Shallow near-surface velocity anomalies, out-of-plane arrivals including fault plane reflections, and, occasionally, water reverberation variations contribute locally to the data mis-ties. Location errors are ubiquitous but of secondary importance, and random noise is more than 20 dB down.A simple and inexpensive routine splice display of line intersection data can be of significant value for quality control, for processing evaluation, and for interpretation. Issues of data reliability, such as screening of amplitude-versus-offset (AVO) anomalies by shallow gas and transmission-path problems for large CMP offsets, as well as other problems in operational and research geophysics, may be addressed by analysis of line intersections in the offset domain.
Multiple granular cell tumors of the bronchi: treatment with laser. (1979)

Granular cell tumors involving multiple bronchial and extrapulmonary sites were found in a young man. Carbon dioxide laser ray was applied through a specially fitted rigid bronchoscope to a lesion at the left mainstem bronchus. Serial follow-up bronchoscopies revealed a white scarred plaque without evidence of regrowth. A partially obstructing lesion at the left lower lobe bronchus did not respond to one application of laser therapy. Laser treatment of proximal benign bronchial lesions is feasible; however, peripheral lesions may require several courses of laser therapy.
Preparation of Hierarchical Hollow CaCO<sub>3</sub> Particles and the Application as Anticancer Drug Carrier (2008)

One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.
Towards a perpetual wireless sensor node (2013)

We report our experimental findings on a perpetual wireless sensor node. Our perpetual node is based on the integration of a wireless sensor node that runs IEEE 802.15.4e technology on TI's MSP430 with a solar energy harvesting module that is based on TI's bq25504 modules. We show that by default running the time synchronized channel hopping (TSCH) MAC layer draws more power than the harvester is able to provide. To close that gap, enhancements that improve the power efficiency of TSCH protocol are described and results are presented. The enhancements proposed consist of shared slot suppression, slotframe skipping, and connection setup time reduction. It is shown that even with these enhancements consumed power is still greater than harvested power. We provide future directions on how to further reduce consumed power at the node.
Nanotechnology: basic concepts and definitions (1994)

Molecular nanotechnology is an engineering discipline in which the goal is to build devices and structures that have every atom in the proper place. By means of this general purpose material-processing technology it will be possible to build almost any rigid, covalently bonded structure. Identical parts will be truly identical, enabling energy conversion and computation systems to have extremely high performance and reliability. Assembly will be done by mechanosynthesis, the process of holding two reactive molecules in contact with each other in a controlled orientation. Synthesis will be done on nanoscale assembly lines called molecular mills, where systems of moving belts will press individual molecules together and catalyze 10(6) reactions/s per station. High-performance mechanical computers will use moving rods to block the motion of other rods. The most important physical limit will be radiation damage. Without redundancy, a subsystem lasting 100 years will be limited to 10(6) nm3.
Programming Nanopore Ion Flow for Encoded Multiplex MicroRNA Detection (2014)

Many efforts are being made in translating the nanopore into an ultrasensitive single-molecule platform for various genetic and epigenetic detections. However, compared with current approaches including PCR, the low throughput limits the nanopore applications in biological research and clinical settings, which usually requires simultaneous detection of multiple biomarkers for accurate disease diagnostics. Herein we report a barcode probe approach for multiple nucleic acid detection in one nanopore. Instead of directly identifying different targets in a nanopore, we designed a series of barcode probes to encode different targets. When the probe is bound with the target, the barcode group polyethylene glycol attached on the probe through click chemistry can specifically modulate nanopore ion flow. The resulting signature serves as a marker for the encoded target. Therefore counting different signatures in a current recording allows simultaneous analysis of multiple targets in one nanopore. The principle of this approach was verified by using a panel of cancer-derived microRNAs as the target, a type of biomarker for cancer detection.
Current progress in the gene therapy of cancer (1996)

Gene transfer for the treatment of cancer is a rapidly expanding field. Recent studies can be divided into four main areas: 1) transfer of suicide genes that convert inactive prodrugs into cytotoxic compounds, 2) transfer of genes encoding cytokines and stimulatory markers to enhance immunogenicity against tumors, 3) transfer of tumor-suppressor genes to block tumor cell proliferation, and 4) transfer of drug resistance genes into hematopoietic stem cells to increase their resistance to myelo-suppressive chemotherapeutic agents. This review discusses recent advances in technique and knowledge and their application to the gene therapy of cancer.
Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents (2021)

Phenanthroindolizidines, such as antofine and tylophorine, are a family of natural alkaloids isolated from different species of <i>Asclepiadaceas.</i> They are characterized by interesting biological activities, such as pronounced cytotoxicity against different human cancerous cell lines, including multidrug-resistant examples. Nonetheless, these derivatives are associated with severe neurotoxicity and loss of in vivo activity due to the highly lipophilic nature of the alkaloids. Here, we describe the development of highly polar prodrugs of antofine and tylophorine as hypoxia-targeted prodrugs. The developed quaternary ammonium salts of phenanthroindolizidines showed high chemical and metabolic stability and are predicted to have no penetration through the blood-brain barrier. The designed prodrugs displayed decreased cytotoxicity when tested under normoxic conditions. However, their cytotoxic activity considerably increased when tested under hypoxic conditions.
Systèmes aromatiques à 10 électrons π dérivés de l'aza-3a-pentalène. XI. Etude par résonance magnétique nucléaire de l'imidazo [1,2-<i>b</i>] pyrazole et du pyrazolo [1,5-<i>a</i>] benzimidazole (1974)

Nuclear magnetic resonance spectroscopy has allowed us to determine the annular tautomerism in two [5,5]-heteroaromatic systems and the position of the acetyl group in their acetyl derivatives. In each case, the more stable compound is the one in which the imidazolic nitrogen atom is bearing H or COCH 3 . We have also found unusual couplings with the N—H in the N-unsubstituted compounds and abnormally high barriers for the azolides. These observations agree well with the hypothesis of a decrease in the aromaticity of the imidazolic part.
qPCR, dPCR, NGS – A journey (2015)

Scientific conferences fulfil many roles, but one of the most important ones is that they help shape the direction in which a scientific discipline grows by promoting person-to-person exchanges of information, ideas and constructive criticisms between scientists from different backgrounds. This interaction also helps to identify areas of controversy and promotes efforts to address and, it is hoped, resolve them. This year is the 30th anniversary of the publication of the first practical description of the polymerase chain reaction [1], arguably one of the simplest and the most widely used molecular technology. It also sees the 7th instalment of the Freising PCR meetings (http://www.qpcr-ngs-2015.net/), which are the longest established, continuous and most influential conferences in this field and have provided a looking glass for conceptual and technical innovation as well as practical applications of PCR-associated methods.
Functional Elements of the Strong <i>psbAI</i> Promoter of <i>Synechococcus elongatus</i> PCC 7942 (2001)

The psbAI gene of the cyanobacterium Synechococcus elongatus PCC 7942 is one of three psbA genes that encode a critical photosystem II reaction center protein, D1. Regulation of the gene family in response to changes in the light environment is complex, occurs at transcriptional and posttranscriptional levels, and results in an interchange of two different forms of D1 in the membrane. Expression of psbAI is downregulated under high-intensity light (high light) in contrast to induction of the other two family members. We show that, in addition to a known accelerated degradation of the psbAI message, promoter activity decreases upon exposure to high light. Unlike the other psbA genes, additional sequences upstream of the psbAI -35 element are required for expression. Mutagenizing the atypical psbAI -10 element from TCTCCT to TATAAT increased the magnitude of expression from both psbAI::lacZ and psbAI::luxAB fusions but did not affect downregulation under high light. Inactivation of group 2 sigma factor genes rpoD2 and sigC, in both wild-type and -10-element mutagenized backgrounds, resulted in elevated psbAI::luxAB expression but did not alter the response to high light. The results are consistent with redundancy of promoter recognition among cyanobacterial group 2 sigma factors. Electrophoretic mobility shift assays showed that the DNA sequence corresponding to the untranslated leader of the psbAI message binds one or more proteins from an S. elongatus extract. The corresponding region of psbAII efficiently competed for this binding activity, suggesting a shared regulatory factor among these disparately regulated genes.
Interferon and Cell Division. IX. Interferon-Resistant L1210 Cells: Characteristics and Origin2 (1974)

Journal Article Interferon and Cell Division. IX. Interferon-Resistant L1210 Cells: Characteristics and Origin Get access Ion Gresser, Ion Gresser Search for other works by this author on: Oxford Academic PubMed Google Scholar Marie-Thérèse Bandu, Marie-Thérèse Bandu Search for other works by this author on: Oxford Academic PubMed Google Scholar Danièle Brouty-Boyé Danièle Brouty-Boyé Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 2, February 1974, Pages 553–559, https://doi.org/10.1093/jnci/52.2.553 Published: 01 February 1974 Article history Received: 13 July 1973 Accepted: 19 October 1973 Published: 01 February 1974
Epitaxial Growth of ZnInON Films with Tunable Band Gap from 1.7 to 3.3 eV on ZnO Templates (2013)

Epitaxial ZnInON (ZION) films with a tunable band gap have been successfully fabricated by RF magnetron sputtering on ZnO templates prepared via nitrogen mediated crystallization (NMC). X-ray diffraction (XRD) measurements show that the full widths at half maximum of the rocking curves from (002) and (101) planes are small at 0.10 and 0.08°, respectively, indicating a high crystallinity with good in-plane and out-of-plane alignments. Since the coherent growth of 35-nm-thick ZION films on NMC-ZnO templates is deduced from the reciprocal space mapping around the (105) diffraction, there is little lattice relaxation at the interface between the films and templates, which is significant in terms of the suppression of carrier recombination. The band gap of the ZION films has been tuned in a wide range of 1.7–3.3 eV by changing the Zn:In ratio. These results indicate that ZION is a potential absorption layer material of solar cells.
Pharmacokinetics of Subcutaneously Administered CB2679d/ISU304 in Wild-Type and Hemophilia B Mice (2016)

Abstract The rapid clearance of factor IX (FIX) necessitates frequent intravenous IV administrations to achieve effective prophylaxis for patients with hemophilia B (HB). Subcutaneous (SC) administration would be a preferred route of administration but has been limited by low bioavailability and potency of the marketed FIX products. CB2679d/ISU304 with enhanced biological properties was developed using a rational protein design approach and has resistance to inhibition by ATIII, increased affinity for FVIIIa, increased catalytic activity and resultant 20-fold enhanced potency in vitro (clotting activity) and in vivo (the tail clip model) and 8-fold increased duration of aPTT activity in vivo compared to recombinant wild-type FIX dosed at the same mass. ISU304 (4622 IU/mg) was injected into HB mice SC with a single dose ISU304 at 0.02, 0.05 or 0.15 mg/kg and sampled at 4, 6, 8, 24 hours. Groups of wild-type mice received ISU304 0.02, 0.05 or 0.15 mg/kg SC and BeneFIX (273 IU/mg) 0.15 mg/kg SC, and sampled at 0.25, 1, 4, 8, 24, 48, 72, and 96 hours. Daily SC injection in HB mice of ISU304 at 0.05 mg/kg was sampled at 24, 48, 72 and 96 hours. FIX antigen was measured using a sandwich ELISA and FIX activity was measured using a one-stage clotting assay on Stago Compact. Pharmacokinetics of FIX was performed using PKSolver. There was a dose-dependent increase of plasma FIX antigen with SC ISU304. Mass-based pharmacokinetic profiles of ISU304 (t1/2, 18 hours; Tmax,8 hours, Bioavailability, 19-22%) were similar to those of BeneFIX (t1/2, 20 hours; Tmax, 8 hours, Bioavailability, 16%). Due to ISU304 high specific activity, SC dose of ISU304 yields much higher FIX activities in mouse plasma compared with the same mass dose of BeneFIX. Daily SC dosing of ISU304 230 IU/kg reached steady-state plateau FIX 8% activity after three injections. The bioavailability and increased potency of CB2679d/ISU304 facilitates the initiation of the Phase 1 subcutaneous dosing study in individuals with hemophilia B. Figure 1 Figure 1. Table 1 Table 1. Figure 2 Figure 2. Disclosures Hong: ISU Abxis: Employment. Levy:Catalyst Biosciences: Employment. Jung:ISU Abxis: Employment. Park:ISU Abxis: Employment. Seo:ISU Abxis: Employment. Seo:ISU Abxis: Employment. Madison:Catalyst Biosciences: Employment, Equity Ownership, Patents & Royalties.
A Latent Variable Recurrent Neural Network for Discourse Relation Language Models (2016)

This paper presents a novel latent variable recurrent neural network architecture for jointly modeling sequences of words and (possibly latent) discourse relations between adjacent sentences. A recurrent neural network generates individual words, thus reaping the benefits of discriminatively-trained vector representations. The discourse relations are represented with a latent variable, which can be predicted or marginalized, depending on the task. The resulting model can therefore employ a training objective that includes not only discourse relation classification, but also word prediction. As a result, it outperforms state-of-the-art alternatives for two tasks: implicit discourse relation classification in the Penn Discourse Treebank, and dialog act classification in the Switchboard corpus. Furthermore, by marginalizing over latent discourse relations at test time, we obtain a discourse informed language model, which improves over a strong LSTM baseline.
ARBEITSPLATZ FAHRER. EINE ERGONOMISCHE STUDIE (1985)

AUS EINER KNAPPEN DARSTELLUNG DER IDDEENTWICKLUNG FUER DIE KRAFTFAHRZEUGTECHNIK KANN ENTNOMMEN WERDEN, DASS SICH DIE BEDIENUNG DES KRAFTFAHRZEUGES ZUNAECHST WESENTLICH AUS TECHNISCHEN NOTWENDIGKEITEN ERGIBT. BEI DEM HEUTIGEN STAND DER MIKROPROZESSORENENTWICKLUNG IST ES JEDOCH MOEGLICH, DIESE BEDIENUNG UNTER DER BLICKRICHTUNG DER MENSCHLICHEN FAEHIGKEIT ZU ENTWICKELN. DIE UNTER DEM BEGRIFF SYSTEMERGONOMIE ZUSAMMENGEFASSTEN KENNTNISSE ERMOEGLICHEN ES, HIERFUER VORSCHLAEGE ZU ENTWICKELN. DANACH GLIEDERT SICH DIE FAHRAUFGABE IN DIE HIERARCHISCH INEINANDER VERSCHACHTELTEN TEILAUFGABEN DER NAVIGATION, FAHRZEUGFUEHRUNG UND STABILISIERUNG. FUER DIE STABILISIERUNG WIRD EIN ZWEIDIMENSIONALES AKTIVES BEDIENELEMENT VORGESCHLAGEN, AN DESSEN STELLUNG DER FAHRER DIE AUGENBLICKLICHE LAENGS- BZW. QUERGESCHWINDIGKEIT HAPTISCH FUEHLEN KANN. FUER DIE FUEHRUNGSAUFGABE WIRD DIE ANZEIGE DES BREMSWEGES, DES NOTWENDIGEN UEBERHOLWEGES UND DER MAXIMAL MOEGLICHEN ABWEICHUNG VORGESCHLAGEN. DURCH DIE ANGABEN DIESER GROESSEN KANN VERHINDERT WERDEN, DASS DER FAHRER GEGEBENE PHYSIKALISCHE GRENZEN, DIE DAS LINEARE UEBERTRAGUNGSVERHALTEN DES FAHRZEUGS EINSCHRAENKEN, UEBERSCHREITET. UM DIE GANANNTEN GROESSEN AN DIE AKTUELLEN BEDINGUNGEN DER VERKEHRSSITUATION ANPASSEN ZU KOENNEN, MUESSEN SIE AUS ERGONOMISCHER SICHT IN HEAD-UP-DISPLAY-TECHNIK (HUD-TECHNIK) ANGEZEIGT WERDEN. DADURCH WERDEN SIE UNMITTELBAR AN DER ENTSPRECHENDEN STELLE IN DER REALEN UMGEBUNG SICHTBAR. FUER DIE NAVIGATIONSAUFGABE KANN EINE AUTOMATISCHE WEGWEISUNG EMPFOHLEN WERDEN, DIE DIE LANDKARTENINFORMATIONEN Z.B. AUF MAGNETISCHEN DATENTRAEGERN ENTHAELT UND BEI DER DIE IST-POSITION DES FAHRZEUGS NACH EINEM DER DAFUER BEREITS VERWENDETEN VERFAHREN (Z.B. AUSWERTUNG DES MAGNETISCHEN ERDFELDES) GEMESSEN WIRD UND DER SICH DARAUS ERGEBENDE WEG ZUR ZIELSTELLE ZEITGERECHT BERECHNET WIRD. AUCH DIESE ANZEIGE SOLLTE IN HUD-TECHNIK ERFOLGEN. ES WIRD GEZEIGT, DASS INSBESONDERE DIE VERWENDUNG DES AKTIVBEN BEDIENELEMENTS FUER DIE ANTHROPOMETRISCHE AUSLEGUNG DES FAHRZEUGS POSITIVE KONSEQUENZEN HAT. (A*)
Maturation in vitro of human oocytes from unstimulated cycles: selection of the optimal day for ovum retrieval based on follicular size (1999)

The potential use of immature oocytes for in-vitro fertilization (IVF) requires the conditions for successful maturation to be defined. This study focused on the day of oocyte retrieval. The selection of a dominant follicle may induce endocrine changes in the remaining cohort that may be detrimental to their subsequent fertilization and embryonic development. Natural cycles in volunteer donors were followed by measurement of serum oestradiol and by vaginal ultrasound, starting on day 3 of the cycle. Cycles were randomly allocated to one of two groups: group 1 (n = 10), in which follicles were aspirated before the leading follicle was 10 mm in diameter; and group 2 (n = 9), in which follicles were aspirated when a dominant follicle was clearly visible with diameter >10 mm. Oocytes were cultured in vitro to metaphase II (MII) stage, donated, and inseminated by intracytoplasmic sperm injection (ICSI) with husband's spermatozoa. Those that became fertilized within 24 h were further co-cultured in autologous endometrial epithelial cells up to the blastocyst stage, and cryopreserved. There was a significantly (P < 0.05) increased rate of oocyte retrieval in group 1 (70.8% of aspirated follicles) compared with group 2 (50.5%). Maturation to MII and fertilization were similar between the groups. However, development to blastocyst stage was significantly (P < 0.05) higher in group 1 embryos (56.5%) compared with group 2 (35.7%). There was a positive correlation (r2 = 0.1978) between the appearance of the cumulus cells and the ability to develop to blastocyst stage when both parameters were analysed in group 1, whereas no such correlation was found in group 2. In conclusion, our data suggest the importance of retrieving immature oocytes before follicular selection, and define the conditions for the first stage in the use of immature oocytes. Further stages must be defined before this technique can be used clinically.
AN APPARATUS FOR DETERMINING THE ACTUAL FOOTPRINT AREA OF TIRES (1970)

AN APPARATUS FOR MEASURING THE ACTUAL CONTACT AREA OF TIRES REGARDLESS OF THEIR TREAD DESIGN IS DESCRIBED. THE PROCEDURE IS BOTH RAPID AND ACCURATE. THE METHOD UTILIZES A BANK OF LIGHTS, AN OPAL GLASS PLATE, A SIMPLE LIGHT FOCUSING SYSTEM, AND A SILICON SOLAR CELL WHICH LINEARLY TRANSFORMS THE INCIDENT LIGHT TO AN ELECTRICAL CURRENT. THE REDUCTION IN CURRENT IS THE MEASURE OF THE TRUE CONTACT AREA OF THE TIRE. /AUTHOR/
End-to-End Text Recognition with Hybrid HMM Maxout Models (2013)

The problem of detecting and recognizing text in natural scenes has proved to be more challenging than its counterpart in documents, with most of the previous work focusing on a single part of the problem. In this work, we propose new solutions to the character and word recognition problems and then show how to combine these solutions in an end-to-end text-recognition system. We do so by leveraging the recently introduced Maxout networks along with hybrid HMM models that have proven useful for voice recognition. Using these elements, we build a tunable and highly accurate recognition system that beats state-of-the-art results on all the sub-problems for both the ICDAR 2003 and SVT benchmark datasets.
Two-dimensional bar code mobile commerce - Implementation and performance analysis (2010)

Two-dimensional bar code is called in Japan, QR Code (Quick Response Code, quick response codes). Holding a camera phone in front of this small black box according to what, after the phone software to identify, quickly turned into a line on the site, connected to the site, you can get the information you need. Of course, not necessarily a website, small black box may also be represented by e-mail, image data or text data. The study of this system in different two-dimensional bar code Shoujizuoye. The Implementation and performance analysis, in which experiments can see, network quality of service is subject to various factors Ying Xiang, to send Therefore, in the Internet video O'clock, must consider the status of the network, to the decision to adopt the GOP pattern; on streams in the network, the packet error rate will change the packet loss probability, affect the image quality.
Studies on antibiotics from the genus Bacillus. XII. The constituent amino acids and fatty acid of antibiotic 333-25. (1976)

Measurement of the optical rotational activities of the constituent amino acids of antibiotic 333-25 identified 2,4-diaminobutyric acid (D-form 1, L-form 4), L-leucine (2) and D-phenylalanine (1). The fatty acid constituent was determined to be beta-hydroxy anteisononanoic acid by gas chromatography, nuclear magnetic resonance and mass spectra. Differentiation from the structure of antibiotic EM 49 is discussed.