gebhart/patrepeval huggingface dataset:
A 28-nm 75-fs<sub>rms</sub> Analog Fractional-$N$ Sampling PLL With a Highly Linear DTC Incorporating Background DTC Gain Calibration and Reference Clock Duty Cycle Correction (2019)

An analog fractional- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> sampling phase-locked loop (PLL) is presented. It achieves 75-fs rms jitter, integrated from 10 kHz to 10 MHz, and a −249.7-dB figure of merit (FoM) at the fractional- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> mode with a 52-MHz reference clock. The measured fractional spur is less than −64 dBc across the 5.5–7.3-GHz output frequency band. The PLL employs digital-to-time converter (DTC)-based sampling PLL architecture, high linearity DTC design techniques, background DTC gain calibration, and reference clock duty cycle correction (DCC) to improve the integrated phase noise (IPN) and fractional spur. This design meets the performance requirement of the 5G cellular 64-quadratic-amplitude modulation (QAM) standard in the 28-/39-GHz band, supporting <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$2 \times 2$ </tex-math></inline-formula> multi-in multi-out (MIMO). This paper, implemented in a 28-nm CMOS process, is integrated in a 5G millimeter-wave cellular transceiver. This PLL consumes 18.9 mW and occupies 0.45 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Waste Lime as a Potential Cation Source in the Phosphate Crystallization Process (2006)

In this study, the feasibility of waste lime as a potential cation source in phosphate crystallization process was investigated using laboratory scale up flow reactors, adopting sequencing batch type configuration. This research focused on its successful application in a novel sludge treatment process, which is comprised of a high performance fermenter (operating conditions: 55 degree C and pH 9) followed by a crystallization reactor. In the struvite precipitation test using synthetic wastewater, considerable nutrient removal (about 60%) in the form of ammonia and phosphate was observed within 0.5-1 hr of retention time, and only small amounts (< 5%) of ammonia stripping occurred naturally due to the alkaline (pH 9) characteristic of the feed substrate. By replacing the synthetic wastewater with the fermentation effluent, the optimal dosage of magnesium salt for struvite precipitation was 0.86 g Mg g(-1) P, similar to the mass ratio of the struvite. The optimal dosage of waste lime was 0.3 g 1(-1), resulting in 80 % of NH4-N and 41% of PO3-P removal, at about 3 hrs of retention time. Microscopic analysis showed that amorphous crystals were mainly observed in the settled solids with waste lime addition whereas prism-like crystals were found in the system with magnesium salt added. Mass balance analysis in full-scale model plants (Q=158,880 m(3)d(-1)) based on the present experimental results revealed that nutrient recycle loading from side stream to main liquid stream would be significantly reduced. The results of the experiment reveal that reuse of industrial waste lime in a nutrient recovery system has the various advantages such as higher economical benefits and sustainable treatment of the industrial waste.
Cloning and Sequencing of an Alkaline Protease Gene from <i>Bacillus lentus</i> and Amplification of the Gene on the <i>B. lentus</i> Chromosome by an Improved Technique (2000)

A gene encoding an alkaline protease was cloned from an alkalophilic bacillus, and its nucleotide sequence was determined. The cloned gene was used to increase the copy number of the protease gene on the chromosome by an improved gene amplification technique.
Randomized comparison of oral fluconazole versus oral polyenes for the prevention of fungal infection in patients at risk of neutropenia (1993)

An open, randomized study was performed at 18 European centres to compare the efficacy, safety and tolerance of oral fluconazole with oral polyenes for the prophylaxis of fungal colonization and infection in adults at high risk of developing neutropenia. Five hundred and thirty-six hospitalized patients with malignant disease, about to receive chemotherapy, radiotherapy, or bone marrow transplantation, and who were already neutropenic or were expected to develop neutropenia were included in the study. Before therapy or transplantation, patients commenced either oral fluconazole therapy (50 mg/day as a single dose) or oral polyenes therapy (amphotericin B 2 g/day and/or nystatin 4 x 10(6) units/day in four or more divided doses), for a mean of 29.3 days and 31.3 days, respectively. After baseline clinical and mycological testing, patients were re-evaluated at least weekly during prophylaxis, at the end of prophylaxis and two to six weeks later to identify proven or suspected fungal infection and to determine rates of colonization with fungi. Fungal infection was diagnosed in 41 of 511 evaluable patients, 10 (3.9%) of 256 in the fluconazole group and 31 (12.2%) of 255 in the polyene group (P = 0.001). This total included four patients (1.6%) in the fluconazole group who developed oropharyngeal candidiasis compared with 22 (8.6%) in the polyene group (P < 0.001). Systemic infections comprised 6 (2.3%) in the fluconazole group and 9 (3.5%) in the polyene group (P = not significant), and included three Candida krusei infections in each group. Parenteral amphotericin B therapy was given empirically for persistent fevers in an additional 62 (24.2%) patients receiving fluconazole and 59 (23.1%) receiving polyenes (P = not significant). Colonization with fungi was generally similar in each treatment group, although an increased proportion of patients receiving fluconazole developed colonization of the faeces (P < 0.01). Adverse reactions, possibly related to treatment, were recorded in 15 (5.6%) of 269 patients in the fluconazole group and 14 (5.2%) of 267 in the polyene group; these necessitated discontinuation of therapy in seven patients in each group. Once-a-day fluconazole was therefore more effective than oral polyenes for the prevention of oropharyngeal fungal infection and as effective for the prevention of infections at other sites in patients with neutropenia.
Direct involvement of σ-1 receptors in the dopamine D <sub>1</sub> receptor-mediated effects of cocaine (2010)

It is well known that cocaine blocks the dopamine transporter. This mechanism should lead to a general increase in dopaminergic neurotransmission, and yet dopamine D(1) receptors (D(1)Rs) play a more significant role in the behavioral effects of cocaine than the other dopamine receptor subtypes. Cocaine also binds to σ-1 receptors, the physiological role of which is largely unknown. In the present study, D(1)R and σ(1)R were found to heteromerize in transfected cells, where cocaine robustly potentiated D(1)R-mediated adenylyl cyclase activation, induced MAPK activation per se and counteracted MAPK activation induced by D(1)R stimulation in a dopamine transporter-independent and σ(1)R-dependent manner. Some of these effects were also demonstrated in murine striatal slices and were absent in σ(1)R KO mice, providing evidence for the existence of σ(1)R-D(1)R heteromers in the brain. Therefore, these results provide a molecular explanation for which D(1)R plays a more significant role in the behavioral effects of cocaine, through σ(1)R-D(1)R heteromerization, and provide a unique perspective toward understanding the molecular basis of cocaine addiction.
Chronic Pulmonary Aspiration in Children (1993)

According to established diagnostic and therapeutic guidelines for chronic pulmonary aspiration, clinical suspicion is raised by coughing and choking with feeding, coughing during sleep, recurrent pneumonia, failure to thrive, and radiologic signs of chronic lung injury. The upper gastrointestinal series accurately defines anatomy and function, can differentiate between direct and reflux aspiration, and identifies conditions that predispose to aspiration. Gastroesophageal scintigraphy lacks anatomic detail but increases observation time, may differentiate between direct and reflux aspiration, and identifies delayed gastric emptying and gastroesophageal reflux. The lipid-laden macrophage index improves identification of aspiration, but cannot differentiate between direct and reflux aspiration. The esophageal pH probe identifies gastroesophageal reflux. Treatment options include medical therapy (thickened feedings, prone positioning, and metoclopramide) and surgical intervention (gastrostomy, fundoplication, and definitive correction of predisposing conditions). Therapy is determined by severity of illness and results of diagnostic evaluation.
Transplantation of Isolated Hepatocytes and Their Role in Extrahepatic Life Support Systems (1995)

Transplantation of isolated hepatocytes for the replacement of liver function and the use of isolated hepatocytes as a bridge-to-transplantation in extrahepatic bioartificial liver support devices offer important therapeutic advances for treating severe liver disease. Progress in cell biology, tissue culture techniques and biotechnology have led the way for the potential therapeutic use of isolated hepatocytes in a wide array of liver disorders. Transplanted hepatocytes show considerable promise of performing the full range of liver functions in several animal models of liver disease, ranging from fulminant hepatic failure to congenital metabolic liver disease. Recently, several interesting designs for extrahepatic liver support systems have been proposed. Although there is no current consensus on its eventual design configuration, the hollow fiber hepatocyte bioreactor design has the greatest potential for therapeutic benefit.
Reinforcement of Stereolithographic Resins for Rapid Prototyping with Cellulose Nanocrystals (2012)

We report on the mechanical properties of optically curable stereolithographic resins (SLRs) which were reinforced through the addition of small amounts of cellulose nanocrystals (CNCs). The resin/filler mixtures are readily accessible via simple mixing processes. A detailed rheological investigation of such mixtures and the successful processing of these materials on a commercial SLR machine show that at low filler concentrations (below 5%) the processability of the materials is barely impacted. The storage modulus, E', increased steadily with increasing CNC content in the regimes below and above the glass transition. A remarkable modulus enhancement was observed in the rubbery regime, where E' increased by 166, 233, and 587% for CNC/SLR nanocomposites with 0.5, 1.0, and 5.0% w/w CNC, respectively. The modulus increase was less pronounced in the glassy state, where E' increased by 21, 32 and 57%, for the same compositions. The increase in tensile strength was of similar magnitude. In comparison to previously reported CNC and carbon-nanofiller based nanocomposites, the presently investigated nanocomposites display a comparably large increase of stiffness and strength, which appear to originate from the high level of dispersion and the intimate contact of the CNCs with the SLR matrix. Through the fabrication of 3-dimensional parts, it was shown that the CNC-filled resins can be processed with standard equipment in a stereolithographic process that is widely used for rapid prototyping and rapid manufacturing.
Adherent cells suppress measles and herpes simplex I virus-induced blastogenesis of multiple sclerosis lymphocytes. (1985)

Viral antigen-induced blastogenesis of lymphocytes from multiple sclerosis (MS) patients was investigated to determine if the responses were actively suppressed. We found that depletion of adherent cells increased measles and herpes simplex I virus antigen-induced transformation of MS lymphocytes. Addition of indomethacin to cultures of unfractionated MS lymphocytes also caused an increase in viral antigen-induced responses. These two facts, plus finding that the cell type mediating the immunosuppression did not rosette with 2-aminoethylisothiouronium bromide hydrobromide-treated sheep red blood cells, indicate that the suppressed T-cell responsiveness of MS patients is caused by macrophages rather than T-cells. These results have a major implication for the divergent published data on blastogenesis induced in MS patient lymphocytes by specific antigens, viral or otherwise. We feel the inconsistencies may simply have arisen from the different lymphocyte isolation and washing procedures used giving variable levels of macrophages and, hence, variable levels of immune suppression. This clearly suggests that induction of blastogenesis in MS patient lymphocytes by a wider array of infectious agent antigens and by various neural antigens should now be undertaken using adherent cell-depleted lymphocytes.
Increased iNOS activity is essential for pulmonary epithelial tight junction dysfunction in endotoxemic mice (2004)

A murine endotoxemia model and cultured Calu-3 monolayers were used to test the hypothesis that excessive nitric oxide (NO) production secondary to induction of inducible NO synthase (iNOS) is a key factor leading to altered tight junction (TJ) protein expression and function in the pulmonary epithelium. C57Bl/6J mice were injected with either Escherichia coli 0111:B4 lipopolysaccharide (LPS; 2 mg/kg) or vehicle. Twelve hours later, leakage of FITC-dextran (M(r) 4 kDa; FD4) from blood into bronchoalveolar lavage fluid was significantly increased in endotoxemic but not control mice. This decrease in bronchoalveolar barrier function was associated with upregulation of iNOS protein expression and NF-kappaB activation in lung tissue. Expression of the TJ proteins, zonula occludens (ZO)-1, ZO-2, ZO-3, and occludin, as assessed by immunoblotting and/or immunofluorescence, decreased in lung after the injection of mice with LPS. Treatment of endotoxemic mice with an isoform-selective iNOS inhibitor [l-N(6)-(1-iminoethyl)lysine; l-NIL] ameliorated LPS-induced changes in TJ protein expression and preserved bronchoalveolar epithelial barrier function. Incubating Calu-3 bronchiolar epithelial monolayers with cytomix (a mixture of 1,000 U/ml IFN-gamma, 10 ng/ml TNF-alpha, and 1 ng/ml IL-1beta) increased permeability to FD4, but adding l-NIL prevented this effect. These results suggest that decreased expression and mistargeting of TJ proteins in lung after systemic inflammation may be NO dependent.
Provenance (2016)

Collecting and processing provenance, i.e., information describing the production process of some end product, is important in various applications, e.g., to assess quality, to ensure reproducibility, or to reinforce trust in the end product. In the past, different types of provenance meta-data have been proposed, each with a different scope. The first part of the proposed tutorial provides an overview and comparison of these different types of provenance. To put provenance to good use, it is essential to be able to interact with and present provenance data in a user-friendly way. Often, users interested in provenance are not necessarily experts in databases or query languages, as they are typically domain experts of the product and production process for which provenance is collected (biologists, journalists, etc.). Furthermore, in some scenarios, it is difficult to use solely queries for analyzing and exploring provenance data. The second part of this tutorial therefore focuses on enabling users to leverage provenance through adapted visualizations. To this end, we will present some fundamental concepts of visualization before we discuss possible visualizations for provenance.
The Use of Micro/Ultrafiltration for the Removal of Oil and Suspended Solids from Oilfield Brines (1992)

Brine generated at offshore and onshore oil recovery facilities is generally treated for removal of oil and suspended solids to meet process and regulatory requirements. Microfiltration (MF) and Ultrafiltration (UF) have been proposed as effective and cost-competitive alternatives to conventional oil removal technology. Recent studies in this field were reviewed to identify current trends and technical obstacles to the implementation of MF/UF technology for oilfield brine treatment. The most extensively demonstrated membrane technology for oilfield brine treatment in North America is a tubular ceramic microfiltration system which employs backflushing and chemical pretreatment. Two commercial installations of this technology are now in place, however, long term viability is uncertain. Lack of an adequate database on both membrane/brine interaction and long term system operations have mitigated against the development of predictive models and correlations necessary to design membrane processes for removal of oil from oilfield brine. The key technical obstacles to cost effective application of membranes include low average flux rates, flux degradation and uncertain membrane life. Concerns regarding integration of membrane processes at oilfield brine treatment facilities include sensitivity to variations in flow and oilfield brine characteristics, handling of waste streams generated using chemical pretreatment and requirements for extensive prefiltration.
Magnetic orientation of borehole cores (1969)

Abstract This paper discusses a method of borehole core orientation based on the observation that when a rock sample is progressively demagnetized in an a-c field, the magnetization vector moves away from the present field direction toward the ancient field direction because the viscous component parallel to the present field is demagnetized by very low a-c fields. In contrast, the component parallel to the ancient field direction is likely to be either TRM or CRM, both of which are extremely stable over long periods of time and against a-c demagnetization. An example of the procedure is given and some problems discussed.
Evolution of Empirical Equations for Prediction of Melting Point and Latent Heat of Alkanes (2016)

Alkanes and paraffins are well recognized phase change materials (PCMs) for low and medium range temperature thermal energy storage applications. Melting point and latent heat are two crucial parameters for any PCM for its use in any thermal storage application. The values of these parameters are normally measured by expensive and time consuming measuring devices. In this paper, three empirical equations are presented to predict the melting point and latent heat of alkanes using carbon number as the only input variable. The theoretical results were found comparable with the experimental results within the error limit of ±3.5% for melting point of alkanes with carbon number between 17 and 60. Latent heat values predicted were also in good agreement with the experimental values. Cite this Article Singh SP, Bhat V. Evolution of Empirical Equations for Prediction of Melting Point and Latent Heat of Alkanes. Journal of Modern Chemistry & Chemical Technology. 2016; 7(3): 8–11p. Normal 0 false false false EN-US X-NONE X-NONE
Effective Replays and Summarization of Virtual Experiences (2012)

Direct replay of the experience of a user in a virtual environment is difficult for others to watch due to unnatural camera motions. We present methods for replaying and summarizing these egocentric experiences that effectively communicate the user's observations while reducing unwanted camera movements. Our approach summarizes the viewpoint path as a concise sequence of viewpoints that cover the same parts of the scene. The core of our approach is a novel content-dependent metric that can be used to identify similarities between viewpoints. This enables viewpoints to be grouped by similar contextual view information and provides a means to generate novel viewpoints that can encapsulate a series of views. These resulting encapsulated viewpoints are used to synthesize new camera paths that convey the content of the original viewer's experience. Projecting the initial movement of the user back on the scene can be used to convey the details of their observations, and the extracted viewpoints can serve as bookmarks for control or analysis. Finally we present performance analysis along with two forms of validation to test whether the extracted viewpoints are representative of the viewer's original observations and to test for the overall effectiveness of the presented replay methods.
Thermoelectricity and resistivity of pyrite from Renison Bell and Mount Bischoff, Tasmania (1962)

Pyrite cubes from many different environments at Renison Bell appear thermoelectrically to be all of the same generation and to have formed at a lower temperature than pyrite from Mt. Bischoff. Slight thermoelectric differences, unattributable to tarnish, exist between polished and unpolished samples. Resistivity measurements obtained using a 4-probe method show that 1) low resistivity is related at room temperature to positive thermoelectricity and 2) pyrite at the base of pyrrhotite sills may have formed at higher temperatures than pyrite within the sills. Spectrographic analyses indicate a tentative correlation between Cu and/or Mo content and high resistivity.
PET Imaging of Extracellular pH in Tumors with<sup>64</sup>Cu- and<sup>18</sup>F-Labeled pHLIP Peptides: A Structure–Activity Optimization Study (2016)

pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants (Var3 and Var7) and wild-type (WT) pHLIP peptides have shown promise for in vivo imaging of breast cancer. Two positron emitting radionuclides ((64)Cu and (18)F) were used to label the NOTA- and NO2A-derivatized Var3, Var7, and WT peptides for in vivo biodistribution studies in 4T1 orthotopic tumor-bearing BALB/c mice. All of the constructs were radiolabeled with (64)Cu or [(18)F]-AlF in good yield. The in vivo biodistribution of the 12 constructs in 4T1 orthotopic allografted female BALB/c mice indicated that NO2A-cysVar3, radiolabeled with either (18)F (4T1 uptake; 8.9 ± 1.7%ID/g at 4 h p.i.) or (64)Cu (4T1 uptake; 8.2 ± 0.9%ID/g at 4 h p.i. and 19.2 ± 1.8% ID/g at 24 h p.i.), shows the most promise for clinical translation. Additional studies to investigate other tumor models (melanoma, prostate, and brain tumor models) indicated the universality of tumor targeting of these tracers. From this study, future clinical translation will focus on (18)F- or (64)Cu-labeled NO2A-cysVar3.