gebhart/patrepeval huggingface dataset:
An integrated database-pipeline system for studying single nucleotide polymorphisms and diseases (2008)

Our system is designed to capture the relationships between SNPs associated with disease and disease-causing genes. The integrated database-pipeline provides a list of candidate genes and SNP markers for evaluation in both epidemiological and molecular biological approaches to diseases-gene association studies. Furthermore, researchers then can decide semi-automatically the data set for association studies while considering the relationships between genetic variation and diseases. The database can also be economical for disease-association studies, as well as to facilitate an understanding of the processes which cause disease. Currently, the database contains 14,674 SNP records and 109,715 gene records associated with human diseases and it is updated at regular intervals.
Expression and Suppression of Human Telomerase RNA (2006)

Telomeres are maintained by the ribonucleoprotein (RNP) enzyme telomerase, which replenishes telomeres through its unique mechanism of internal RNA-templated addition of telomeric DNA. Telomerase is active in most human cancers, typically because its core protein subunit, TERT, is up-regulated. Although the major known function of telomerase in cancer is to replenish telomeric DNA and maintain cell immortality, the regulation of the RNA component of telomerase is not well understood. In the course of investigations that have implicated telomerase RNA in key aspects of cancer progression, including metastasis, we explored some of the cis-acting elements affecting telomerase RNA expression and knockdown. The expression efficiency and subsequent RNA processing to produce the mature hTER differed considerably among various promoters. Together with other results, these findings establish that the crucial elements of the hTER gene affecting RNA-processing efficiency to produce the mature hTER RNA are the promoter and internal telomerase RNA-coding sequences.
Monocular, One-stage, Regression of Multiple 3D People (2021)

This paper focuses on the regression of multiple 3D people from a single RGB image. Existing approaches predominantly follow a multi-stage pipeline that first detects people in bounding boxes and then independently regresses their 3D body meshes. In contrast, we propose to Regress all meshes in a One-stage fashion for Multiple 3D People (termed ROMP). The approach is conceptually simple, bounding box-free, and able to learn a per-pixel representation in an end-to-end manner. Our method simultaneously predicts a Body Center heatmap and a Mesh Parameter map, which can jointly describe the 3D body mesh on the pixel level. Through a body-center-guided sampling process, the body mesh parameters of all people in the image are easily extracted from the Mesh Parameter map. Equipped with such a fine-grained representation, our one-stage framework is free of the complex multi-stage process and more robust to occlusion. Compared with state-of-the-art methods, ROMP achieves superior performance on the challenging multi-person benchmarks, including 3DPW and CMU Panoptic. Experiments on crowded/occluded datasets demonstrate the robustness under various types of occlusion. The code, released at https://github.com/Arthur151/ROMP, is the first real-time implementation of monocular multi-person 3D mesh regression.
Trapping a Diradical Transition State by Mechanochemical Polymer Extension (2010)

Transition state structures are central to the rates and outcomes of chemical reactions, but their fleeting existence often leaves their properties to be inferred rather than observed. By treating polybutadiene with a difluorocarbene source, we embedded gem-difluorocyclopropanes (gDFCs) along the polymer backbone. We report that mechanochemical activation of the polymer under tension opens the gDFCs and traps a 1,3-diradical that is formally a transition state in their stress-free electrocyclic isomerization. The trapped diradical lives long enough that we can observe its noncanonical participation in bimolecular addition reactions. Furthermore, the application of a transient tensile force induces a net isomerization of the trans-gDFC into its less-stable cis isomer, leading to the counterintuitive result that the gDFC contracts in response to a transient force of extension.
Epidermal growth factor in saliva and gastric juice: response to histamine. (1995)

Epidermal growth factor (EGF) was measured in saliva and in gastric juice under basal conditions and after histamine stimulation (0.04 mg kg-1h-1). Sixty subjects studied comprised 20 normal volunteers, 20 patients with duodenal ulcer (DU), and 20 patients with non-ulcer dyspepsia (NUD). There was no difference in basal salivary EGF concentrations between control and DU or control and NUD subjects, but the EGF concentration in DU patients exceeded that in NUD patients (p < 0.05). Basal gastric juice concentrations of EGF were similar in all three groups. There was no difference between basal salivary and gastric EGF concentrations (p > > 0.05). After histamine stimulation, salivary and gastric EGF concentrations increased in all three groups: the increase was greater in gastric juice than saliva (p < 0.0001). There were no significant differences in the salivary EGF concentrations of controls and NUD patients, or controls and DU patients, but values were significantly higher when DU and NUD patients were compared (p = < 0.05). In the gastric juice, EGF increased more in DU patients than in controls or NUD patients (p < 0.05). This effect was not linked to the greater acid secretion in DU than in the other groups. There was no influence of gender or smoking on the EGF concentration. This evidence suggests that the stomach itself may be able to secrete large amounts of EGF and that histamine is a potent stimulus. It is more likely that the gastric EGF is responding to the presence of a duodenal ulcer than that lack of EGF is responsible for persistence of the ulcer.
Strengthening of Glass by Sol‐Gel Coatings (1990)

The affects of alkoxide‐derived coatings on the bending strength of silica glass were investigated. For densified coatings, increases in strength of 120% to 130% were found. A model of the strengthening process, based on the filling‐in and partial healing of surface flaws, is proposed. The model accounts for the temperature dependence of strengthening, the inensitivity of strengthening to the size of oligomers in the coating solution, and the insensitivity of strengthening to the thickness of the coating. The presence of a significant residual tensile stress in sol‐gel‐strengthened material is also indicated.
On the Theory of the Bubble Chamber (1958)

An attempt is made to analyze the factors which determine the operation of the bubble chamber. It is concluded that the majority of bubbles in conventional chambers are nucleated by moderately energetic free electrons produced by the incident particles in Coulomb encounters. Nuclei are displaced too infrequently by Coulomb encounters to account for the observed densities of bubbles. The electrons deposit their kinetic energy in highly localized regions which then are the source of explosions which produce bubbles of greater than critical size in a time of the order of 10−10 or 10−11 sec. The bubbles grow subsequently by evaporation of the fluid. The temperature of the fluid should be sufficiently close to the critical temperature that the energy required to produce the bubble of critical size can be provided by an electron with a range comparable to or less than the diameter of the bubble of critical size. Otherwise the electron will be unable to localize its energy in a sufficiently small volume in any but highly improbable cases. It is also concluded that the viscosity of the liquid plays a very important role in determining the threshold energy for forming a bubble of critical size when it has a value near 1 centipoise or larger.
Ứng dựng hệ thông tin địa lý trong lĩnh vực quốc phòng tại Việt Nam (2012)

không có
Metallic 1T MoS<sub>2</sub> nanosheet arrays vertically grown on activated carbon fiber cloth for enhanced Li-ion storage performance (2017)

Metallic 1T-phase MoS<sub>2</sub> nanosheets have a high concentration of edge active sites and other defects, for enhanced Li-ion storage performance.
Electrical feedthrough for gas pressures up to 10 000 bar and low temperatures (1979)

An electrical gas-tight feedthrough is described which is suitable for use at pressures up to 10 000 bar and temperatures down to -180 degrees C. The capacitance of the feedthrough is about 20 pF.
Proteomics-based Identification of Human Acute Leukemia Antigens That Induce Humoral Immune Response (2005)

The identification of panels of tumor antigens that elicit an antibody response may have utility in cancer screening, diagnosis, and establishing prognosis. Until now, autoimmunity in cancer has been mainly revealed in solid tumors. The aim of this study was to apply the proteomic approach to the identification of proteins that commonly elicit a humoral response in acute leukemia (AL). Sera from 21 newly diagnosed patients with AL, 20 patients with solid tumors, and 22 noncancer controls were analyzed for antibody-based reactivity against AL proteins resolved by two-dimensional electrophoresis. As a result, autoantibody against a protein identified by mass spectrometry as Rho GDP dissociation inhibitor 2 was detected in sera from 15 of 21 patients with AL (71%). By contrast, such antibody was detected in sera from one of 20 patients with solid tumors (5%) and one of 22 noncancer controls (4.5%). Five other protein autoantibodies were also found in AL patients with a high frequency and constituted the major target antigens of the AL autoimmune response. The findings of autoantibodies against Rho GDP dissociation inhibitor 2 and other proteins in sera of patients with AL suggest that the proteomic approach we have implemented may have utility for the development of a serum-based assay for AL screening and diagnosis.
Vectored Gag and Env but Not Tat Show Efficacy against Simian-Human Immunodeficiency Virus 89.6P Challenge in Mamu-A<sup>*</sup>01-Negative Rhesus Monkeys (2005)

Simian-human immunodeficiency virus (SHIV) challenge studies in rhesus macaques were conducted to evaluate the efficacy of adenovirus-based vaccines in the context of different major histocompatibility complex class I genetic backgrounds and different vaccine compositions. Mamu-A*01 allele-negative rhesus monkeys were immunized with one of the following vaccine constructs: (i) replication-defective recombinant adenovirus type 5 (Ad5) expressing human immunodeficiency virus type 1 (HIV-1) Tat (Ad5/HIVTat); (ii) Ad5 vector expressing simian immunodeficiency virus (SIV) Gag (Ad5/SIVGag); (iii) Ad5 vector expressing the truncated HIV-1(jrfl) Env, gp140 (Ad5/gp140_jrfl); (iv) Ad5 vector expressing the SHIV-89.6P gp140 (Ad5/gp140_89.6P); or (v) the combination of Ad5/SIVGag and Ad5/gp140_jrfl. Following intravenous challenge with SHIV-89.6P, only those cohorts that received vaccines expressing Gag or Env exhibited an attenuation of the acute viremia and associated CD4-cell lymphopenia. While no prechallenge neutralizing antibody titers were detectable in either Ad5/gp140-vaccinated group, an accelerated neutralizing antibody response was observed in the Ad5/gp140_89.6P-vaccinated group upon viral challenge. The set-point viral loads in the Ad5/SIVGag- and Ad5/gp140_jrfl-vaccinated groups were associated with the overall strength of the induced cellular immune responses. To examine the contribution of Mamu-A*01 allele in vaccine efficacy against SHIV-89.6P challenge, Mamu-A*01-positive monkeys were immunized with Ad5/SIVGag. Vaccine-mediated protection was significantly more pronounced in the Mamu-A*01-positive monkeys than in Mamu-A*01-negative monkeys, suggesting the strong contributions of T-cell epitopes restricted by the Mamu-A*01 molecule. The implications of these results in the development of an HIV-1 vaccine will be discussed.
A comparison among tapentadol tamper‐resistant formulations (<scp>TRF</scp>) and <scp>O</scp>xy<scp>C</scp>ontin<sup>®</sup> (non‐<scp>TRF</scp>) in prescription opioid abusers (2013)

Tamper-resistant formulations of taptentadol (pain relief) tablets do not appear to be well-liked by individuals who tamper regularly with extended-release oxycodone tablets. Employing tamper-resistant technology may be a promising approach towards reducing the abuse potential of tapentadol extended-release.
High precision indoor positioning using lighting LED and image sensor (2011)

High power white LEDs are expected to replace the existing lighting technologies in near future which are also suggested for visible light communication (VLC). We propose an algorithm for high precision indoor positioning using lighting LEDs, VLC and image sensors. In the proposed algorithm, at least three LEDs transmit their three dimensional coordinate information which are received and demodulated by two image sensors at the unknown position. The unknown position is then calculated from the geometrical relations of the LED images created on the image sensor. This technique does not require any angular measurement. Results from the numerical simulations are explained to understand the effect of different system parameters on positioning accuracy. Based on numerical analyses, we show that the system is able to estimate the unknown position within the accuracy of about 10 centimeters. Positioning accuracy can be increased by using high resolution image sensors.
Using Firewalls to Enforce Enterprise-wide Policies over Standard Client-Server Interactions (2006)

We propose and evaluate a novel framework for enforcing global coordination and control policies over message passing software components in enterprise computing environments. This framework combines the use of firewalls, both per-node software and dedicated firewalls, with an existing coordination and control system to enforce policies that, among other properties, are stateful and communal. The firewalls act as a set of distributed reference monitors that filter messages exchanged between the interacting software components. The coordination and control system coordinates the firewalls to enforce a specific set of policies, passing only messages allowed by these policies. Filtering decisions may be based on credentials presented to the coordination and control system as well as system state accumulated over time. This filtering approach decouples coordination and control from application implementation, allowing the coordination and control mechanism and application implementations to evolve independently of each other. We demonstrate the power of our framework by using it to specify and enforce an RBAC policy with delegation, revocation, and separation-of-duty over accesses to a cluster of NFS and SMB file servers without changing any client or server implementations. Measurements show that our framework imposes acceptable overheads when enforcing this policy.
2-bit adder: carry and sum logic circuits at 19GHz clockfrequency in InAlAs/InGaAs HBT technology (2001)

Carry and sum circuits for a 2-bit adder used in a pipelined 2N-bit adder-accumulator architecture are reported. To obtain high clock rates in a design with multiple gate delays a novel merged AND-OR-Latch structure using four-level series gated current steering logic is employed. These integrated circuits were fabricated in InAlAs/InGaAs transferred substrate heterojunction bipolar transistor technology and operate up to 19 GHz clock rate.
A convenient chemoenzymatic synthesis of (R)- and (S)-(chloromethyl)oxirane (1990)

(R)- and (S)-1-Chloro-3-tosyloxypropan-2-ol have been prepared by biocatalysed enantioselective esterification in hexane, and in turn could be readily converted into optically active (chloromethyl)oxirane in high yield.
Direct Fluorination of Adamantanes with Iodine Pentafluoride (2008)

Direct fluorination of adamantanes was achieved by IF 5 and one or two fluorine atoms were introduced on tert-carbons of the adamantanes selectively.
Novel Insecticidal Chrysanthemic Esters (1969)

Journal Article Novel Insecticidal Chrysanthemic Esters Get access Yoshio Katsuda, Yoshio Katsuda Research Laboratory of Dainippon Jotyugiku Co., Ltd. Search for other works by this author on: Oxford Academic Google Scholar Tadayoshi Chikamoto, Tadayoshi Chikamoto Research Laboratory of Dainippon Jotyugiku Co., Ltd. Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Ogami, Hiroshi Ogami Research Laboratory of Dainippon Jotyugiku Co., Ltd. Search for other works by this author on: Oxford Academic Google Scholar Hajime Hirobe, Hajime Hirobe Shiono Koryo Kaisha, Ltd. Search for other works by this author on: Oxford Academic Google Scholar Tsutomu Kunishige Tsutomu Kunishige Shiono Koryo Kaisha, Ltd. Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 33, Issue 9, 1 September 1969, Pages 1361–1362, https://doi.org/10.1080/00021369.1969.10859476 Published: 01 September 1969 Article history Received: 14 July 1969 Published: 01 September 1969
Use of heparinase to eliminate heparin inhibition in routine coagulation assays. (1972)

Abstract A preparation of partially purified heparinase from Flavobacterium heparinum has been used to normalize the prothrombin times and partial thromboplastin times of plasma samples known to contain heparin. The data suggest that this effect is due entirely to the destruction of heparin, since the heparinase is free of coagulants. Furthermore, it was shown that the heparinase produces no change in the prothrombin time of factor VII-deficient plasma, nor in the partial thromboplastin times of factor IX-deficient or factor VIII-deficient plasma. The usefulness of heparinase in distinguishing between intrinsic coagulopathy and heparin contamination of plasma has been demonstrated in a series of patients. Heparinase is thus shown to be a useful reagent in the diagnostic coagulation laboratory, permitting accurate determination of prothrombin times and partial thromboplastin times on patients receiving heparin.
The Use and Clinical Significance of Transcranial Magnetic Stimulation in the Treatment of Major Depression (2007)

Dr. Demitrack is Vice President and Chief Medical Officer, Neuronetics, Inc., One Great Valley Parkway, Suite 2, Malvern, PA 19355; E-mail: [email protected]. The author has disclosed that he is a stock shareholder of Neuronetics, Inc., Eli Lilly, and Wyeth Pharmaceuticals. The author also has disclosed that the use of the NeuroStar TMS Therapy System as well as the use of estrogen, ketoconazole, lorazepam, and lithium carbonate has not been approved by the U.S. Food and Drug Administration for the treatment of major depression.
Peptidylarginine deiminase 4 (PADI4) identified as a conformation‐dependent autoantigen in rheumatoid arthritis (2005)

PADI4 is an autoantigen in some RA patients, and its conformational epitope(s) may be important.
Effects of N-(4-Hydroxyphenyl)retinamide on hTERT Expression in the Bronchial Epithelium of Cigarette Smokers (2001)

Telomerase is frequently reactivated in the lungs of cigarette smokers. The modulation of hTERT expression in 4-HPR-treated smokers suggests that a novel molecular mechanism underlies the potential chemopreventive properties of 4-HPR. hTERT expression is a promising potential biomarker for risk assessment and for the evaluation of the efficacy of chemopreventive agents in lung carcinogenesis.
Practical issues for building a product ontology system (2005)

A base of clearly defined product information is a key foundation for an e-commerce system. The manipulation and exchange of semantically enriched and precise product information can enhance the quality of an e-commerce system and offer a high level of interoperability with other systems. Product information consists of product attributes and the relationships between products. Product categorization (or classification) is one type of such relationships. Ontology can play an important role in the formalization of product information. Although the idea of utilizing ontology for e-catalogs has been raised before, we are yet to find an operational implementation of applying ontology in the domain. In this paper, we report on our recent effort to build an operational product ontology system for the government procurement service. The system is designed to serve as a product ontology knowledge base; not only for the design and construction of product databases but also for search and discovery of products. We introduce some of the issues that we have experienced in the project, so that our work may serve as a reference model for similar projects in the future.
Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. (1995)

The integrins have recently been implicated in signal transduction. A likely mediator of integrin signaling is focal adhesion kinase (pp125FAK or FAK), a structurally distinct protein tyrosine kinase that becomes enzymatically activated upon engagement of integrins with their ligands. A second candidate signaling molecule is paxillin, a focal adhesion associated, cytoskeletal protein that coordinately becomes phosphorylated on tyrosine upon activation of pp125FAK. Paxillin physically complexes with two protein tyrosine kinases, pp60src and Csk (COOH-terminal src kinase), and the oncoprotein p47gag-crk, each of which could function as part of a paxillin signaling complex. Using an in vitro assay we have established that the cytoplasmic domain of the beta 1 integrin can bind to paxillin and pp125FAK from chicken embryo cell lysates. The NH2-terminal, noncatalytic domain of pp125FAK can bind directly to the cytoplasmic tail of beta 1 and recognizes integrin sequences distinct from those involved in binding to alpha-actinin. Paxillin binding is independent of pp125FAK binding despite the fact that both bind to the same region of beta 1. These results demonstrate that the cytoplasmic domain of the beta subunits of integrins contain binding sites for both signaling molecules and structural proteins suggesting that integrins can coordinate the generation of cytoplasmic signals in addition to their role in anchoring components of the cytoskeleton.
[NiX<sub>2</sub>(NHC)<sub>2</sub>] Complexes in the Hydrosilylation of Internal Alkynes (2011)

Abstract A number of nickel(II) dihalide complexes with small monodentate N‐heterocyclic carbene ligands was synthesized and tested for their catalytic activity in the hydrosilylation of internal alkynes. The nickel(0) active species was obtained from the starting nickel(II) complex by reduction with diethylzinc. In all cases the catalytic reaction yielded the syn product selectively. The fastest catalysts reached full conversion of the symmetric alkyne 3‐hexyne in 60 min at 50 °C, with 5 mol‐% catalyst loading. The asymmetrically substituted internal alkyne 1‐phenyl‐1‐propyne gave full conversion within 30 min. The major product (83 %) was shown to be the expected ( E )‐1‐phenyl‐1‐(triethylsilyl)propene. The active catalyst was demonstrated to be a homogeneous species.
Foam extrusion characteristics of thermoplastic resin with fluorocarbon blowing agent. II. Polystyrene foam extrusion (1983)

The foam extrusion characteristics of three different grades of polystyrene resin were investigated. For the study, cylindrical dies with various values of length-to-diameter ratio, entrance angle, and reservior-to-capillary diameter ratio were used. Fluorocarbon blowing agents were used, and mixtures of citric acid and sodium bicarbonate were used as nucleating agent. It was found that the die temperature, shear rate, the type and concentration of blowing agent, and die geometry affect the quality of the extruded polystyrene foam. Foam density and open cell fraction were used in determining the quality of extruded foams. We have found that the extrudate swell ratio is correlatable to foam density, independent of the die temperature employed. However, the die temperature has been found to be a very sensitive processing variable governing the quality of extruded foams.