gebhart/patrepeval huggingface dataset:
Additive manufacturing of carbon fiber-reinforced plastic composites using fused deposition modeling: Effects of process parameters on tensile properties (2016)

Carbon fiber-reinforced plastic composites have been intensively used for many applications due to their attractive properties. The increasing demand of carbon fiber-reinforced plastic composites is driving novel manufacturing processes to be in short manufacturing cycle time and low production cost, which is difficult to realize during carbon fiber-reinforced plastic composites fabrication in common molding processes. Fused deposition modeling, as one of the additive manufacturing techniques, has been reported for fabricating carbon fiber-reinforced plastic composites. The process parameters used in fused deposition modeling of carbon fiber-reinforced plastic composites follow those in fused deposition modeling of pure plastic materials. After adding fiber reinforcements, it is crucial to investigate proper fused deposition modeling process parameters to ensure the quality of the carbon fiber-reinforced plastic parts fabricated by fused deposition modeling. However, there are no reported investigations on the effects of fused deposition modeling process parameters on the mechanical properties of carbon fiber-reinforced plastic composites. In the experimental investigations of this paper, carbon fiber-reinforced plastic composite parts are fabricated using a fused deposition modeling machine. Tensile tests are conducted to obtain the tensile properties. The effects of fused deposition modeling process parameters on the tensile properties of fused deposition modeling-fabricated carbon fiber-reinforced plastic composite parts are investigated. The fracture interfaces of the parts after tensile testing are observed by a scanning electron microscope to explain material failure modes and reasons.
Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of MDA-MB-231 human breast cancer cells in culture. (2000)

Epidemiological and experimental studies have suggested a protective role of phytosterols (PS) in the development of some types of cancer such as colon and prostate cancer. No work has been reported on the role of PS in the development of breast cancer, the second leading cancer in woman. The present study was designed to examine the effect of the two most common dietary PS, beta-sitosterol (SIT) and campesterol, as compared to cholesterol, the main sterol in the Western diet, on growth, apoptosis and cytotoxicity of MDA-MB-231 human breast cancer cells in culture. In addition, we investigated the possible role of protein phosphatase 2A (PP2A), an enzyme that has been shown to regulate growth and apoptosis in tumor parameters studied. Breast cancer cell growth was found to be inhibited by 66% after 3 days and 80% after 5 days with 16 microM SIT. Both campesterol and cholesterol sustained tumor growth at levels comparable to that of the vehicle control. None of the sterols tested at this level (16 microM) induced cytotoxicity as measured by lactic dehydrogenase release. SIT supplementation for 3 days at 16 microM resulted in a 6-fold increase in apoptosis in cells when compared to cholesterol treated cells. SIT treatment was found to have no effect on the level and content of tumor cell PP2A. It is concluded that SIT, by a still unknown mechanism, may offer protection from breast cancer by inhibiting growth and stimulating apoptosis.
Sulfamylurea Hypoglycemic Agents. II. Drug Dynamic Studies (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfamylurea Hypoglycemic Agents. II. Drug Dynamic StudiesEdward H. Wiseman, J. N. Pereira, K. F. Finger, and Rex Pinson Jr.Cite this: J. Med. Chem. 1965, 8, 6, 777–781Publication Date (Print):November 1, 1965Publication History Published online1 May 2002Published inissue 1 November 1965https://pubs.acs.org/doi/10.1021/jm00330a010https://doi.org/10.1021/jm00330a010research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dynamic network visualization in 1.5D (2011)

The dynamic network visualization has been a challenging topic due to the complexity introduced by the extra time dimension. Existing solutions to this problem are usually good for the overview and presentation, but not for the interactive analysis. We propose in this paper a new approach which only considers the dynamic network central to a focus node (aka dynamic ego network). The navigation of the entire network is achieved by switching the focus node with user interactions. With this approach, the complexity of the compressed dynamic network is greatly reduced without sacrificing the network and time affinity central to the focus node. As a result, we are able to present each dynamic ego network in a single static view, well supporting user analysis on temporal network patterns. We describe our general framework including the network data pre-processing, 1.5D network and trend visualization design, layout algorithms, as well as several customized interactions. In addition, we show that our approach can also be extended to visualize the event-based and multimodal dynamic networks. Finally, we demonstrate, through two practical case studies, the effectiveness of our solution in support of visual evidence and pattern discovery.
Amphiphilic Block Copolymer Micelles: New Dispersant for Single Wall Carbon Nanotubes (2005)

Abstract Summary: This manuscript describes a new simple method to disperse single wall carbon nanotubes (SWNTs) in various organic solvents. The method is based on using amphiphilic block copolymer micelles as a dispersant. We have found that the stabilization of SWNTs by block copolymer micelles adhering to the surface of nanotubes is much superior to that by either surfactants or high‐molecular‐weight polymers currently used. Our nondestructive method is beneficial because the amphiphilic property of the block copolymer micelles enables us to stabilize SWNTs in either polar solvents or nonpolar ones at the same time. We also demonstrate that silver nanoparticles are selectively synthesized in polar cores of micelles adsorbed on the surface of SWNTs and the subsequent heat treatment modifies the surface of SWNTs. Dispersion of silver nanoparticles on the surface of SWNTs. magnified image Dispersion of silver nanoparticles on the surface of SWNTs.
Vertex neighborhoods, low conductance cuts, and good seeds for local community methods (2012)

The communities of a social network are sets of vertices with more connections inside the set than outside. We theoretically demonstrate that two commonly observed properties of social networks, heavy-tailed degree distributions and large clustering coefficients, imply the existence of vertex neighborhoods (also known as egonets) that are themselves good communities. We evaluate these neighborhood communities on a range of graphs. What we find is that the neighborhood communities can exhibit conductance scores that are as good as the Fiedler cut. Also, the conductance of neighborhood communities shows similar behavior as the network community profile computed with a personalized PageRank community detection method. Neighborhood communities give us a simple and powerful heuristic for speeding up local partitioning methods. Since finding good seeds for the PageRank clustering method is difficult, most approaches involve an expensive sweep over a great many starting vertices. We show how to use neighborhood communities to quickly generate a small set of seeds.
An aid to stop thumb sucking: the "Bluegrass" appliance. (1991)

A nonpunitive fixed appliance utilizing a Teflon (E.I. du Pont de Nemours and Co., Inc., Wilmington, DE) roller is described. The appliance is used in conjunction with a program of positive reinforcement in managing thumb sucking in children 7-13 years of age. It has been used successfully in 24 children, with no cases requiring reinsertion.
Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection (2009)

Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand this dichotomy, we compared acute pathogenic SIV infection in pigtailed macaques (PTs) to non-pathogenic infection in African green monkeys (AGMs). SIVagm-infected PTs, but not SIVagm-infected AGMs, rapidly developed systemic immune activation, marked and selective depletion of IL-17-secreting (Th17) cells, and loss of the balance between Th17 and T regulatory (Treg) cells in blood, lymphoid organs, and mucosal tissue. The loss of Th17 cells was found to be predictive of systemic and sustained T cell activation. Collectively, these data indicate that loss of the Th17 to Treg balance is related to SIV disease progression.
Quantum decoherence of the central spin in a sparse system of dipolar coupled spins (2012)

The central spin decoherence problem has been researched for over 50 years in the context of both nuclear magnetic resonance and electron spin resonance. Until recently, theoretical models have employed phenomenological stochastic descriptions of the bath-induced noise. During the last few years, cluster expansion methods have provided a microscopic, quantum theory to study the spectral diffusion of a central spin. These methods have proven to be very accurate and efficient for problems of nuclear-induced electron spin decoherence in which hyperfine interactions with the central electron spin are much stronger than dipolar interactions among the nuclei. We provide an in-depth study of central spin decoherence for a canonical scale-invariant all-dipolar spin system. We show how cluster methods may be adapted to treat this problem in which central and bath spin interactions are of comparable strength. Our extensive numerical work shows that a properly modified cluster theory is convergent for this problem even as simple perturbative arguments begin to break down. By treating clusters in the presence of energy detunings due to the long-range (diagonal) dipolar interactions of the surrounding environment and carefully averaging the effects over different spin states, we find that the nontrivial flip-flop dynamics among the spins becomes effectively localized by disorder in the energy splittings of the spins. This localization effect allows for a robust calculation of the spin echo signal in a dipolarly coupled bath of spins of the same kind, while considering clusters of no more than six spins. We connect these microscopic calculation results to the existing stochastic models. We, furthermore, present calculations for a series of related problems of interest for candidate solid state quantum bits including donors and quantum dots in silicon as well as nitrogen-vacancy centers in diamond.
45-nm silicon-on-insulator CMOS technology integrating embedded DRAM for high-performance server and ASIC applications (2011)

The 45-nm technology, called 12S and developed for IBM POWER7®, is an extremely robust and versatile technology platform that allows for a rich set of features that include embedded dynamic random access memory (DRAM), performance and dense static RAM (SRAM), a trench-based decoupling capacitor, a comprehensive device menu, and a high-performance hierarchical back-end interconnect scheme, all built on a silicon-on-insulator (SOI) substrate. Embedded DRAM was implemented for production in high-performance SOI for the first time and allowed us to leapfrog two generations of conventional SRAM densities. Immersion lithography was also employed for the first time in 45-nm IBM products. Our 45-nm design point represents a judicious leverage of silicon oxynitride dielectrics, scaled device technology, and rich features to yield chip-level performance enhancement of more than 50%, compared with our 65-nm node at comparable or less power. This paper describes the salient features of this technology node, the process architecture, the device design rationale, and the process design interactions.
Luminescence Properties and Energy Transfer of Eu2+ Doped Ca8Mg ( SiO4 ) 4Cl2 Phosphors (1992)

The synthesis and luminescence characteristics of Eu2+ activated calcium magnesium chlorosilicate, , have been reported and analyzed. The emission spectrum of Eu2+ is composed of two separate bands with peaks at 507 and 428 nm, which result from the Eu2+ centers in different crystallographic sites. At room temperature, the excitation spectrum of the very strong 507 nm emission shows not only the broad 4f7‐4f65d excitation bands, but also the fine structure resulting from the splitting of 4f6 configuration in the 4f65d excited state. This structure is explained by the high covalency degree of the cation—anion bonds in this system. Efficient energy transfer between the two inequivalent Eu2+ centers has been evaluated quantitatively.
E2A Basic-Helix-Loop-Helix Transcription Factors are Negatively Regulated by Serum Growth Factors and by the Id3 Protein (1996)

Id3, a member of the Id multigene family of dominant negative helix-loop-helix transcription factors, is induced sharply in murine fibroblasts by serum growth factors. To identify relevant targets of Id3 activity, the yeast two-hybrid system was used to identify proteins that dimerize with Id3. Four murine cDNAs were identified in the screen, all of which encode helix-loop-helix proteins: E12, E47, ALF1 and Id4. Co-immunoprecipitation assays confirm that Id3 interacts with E12, E47 and two alternative splice products of ALF1 in vitro. Id3 disrupts DNA binding by these proteins in vitro and blocks transcriptional activation by these factors in cultured murine cells. Additionally, Id3 shows evidence of interacting with the related proteins E2-2 and MyoD, but not c-Myc. These results suggest that Id3 can function as a general negative regulator of the basic-helix-loop-helix family of transcription factors exemplified by the 'E' proteins and MyoD. Although it was previously suspected that E2A is constitutively expressed, our data indicate that E2A is induced in quiescent fibroblasts, by growth factor withdrawal but not by contact inhibition of cell proliferation. These observations extend the role of Id3 in the functional antagonism of E2A-class transcription factors, and suggest that E2A proteins may mediate growth inhibition.
Bestiality/Zoophilia: A Scarcely Investigated Phenomenon Between Crime, Paraphilia, and Love (2004)

ABSTRACT Sexual contact with animals–frequently referred to as bestiality or zoophilia–is a scarcely investigated subject. Even though the phenomenon has been prevalent throughout history, addressing the subject often seems to evoke prejudices and emotional reactions rather than objective reflection. A large part of the information on bestiality stems from criminological reports. Thus, usually violence and psychiatric disorders are prevalent in those cases. Only a few more recent studies of zoophilia have collected data from voluntary, community samples on the variety of behaviors, motivation, development, and personality involved and have provided new information, in particular on aspects like emotional involvement and the possibility of a zoosexual orientation. In addition to an overview of both the older and more recent literature and research, some implications for practitioners will be provided.
Intrinsic Field Homogeneity Correction in Fast Spin Echo based Amide Proton Transfer MRI (2012)

Amide proton transfer (APT), a powerful technique for molecular imaging of endogenous proteins, is based on an asymmetry analysis of RFsaturation frequency offsets acquired around the water resonance, which needs precise B0 inhomogeneity correction. While fast spin-echo(FSE) based APT has superior contrast-to-noise ratio, the previouslyshown multi-echo APT acquisition with intrinsic Dixon-type B0 mapping is restricted to gradient-echo sequences. We propose a FSE-DixonAPT technique with varied echo time shifts, using iterative Dixon reconstruction across different positive saturation frequency offsetsfor intrinsic B0 mapping and correction. Feasibility in the human head is demonstrated using a clinical 3T scanner.
An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT<sub>7</sub>and 5-HT<sub>1A</sub>Receptor Partial Agonist That Corrects Motor Stereotypy in Mouse Models (2015)

Stereotypy (e.g., repetitive hand waving) is a key phenotype of autism spectrum disorder, Fragile X and Rett syndromes, and other neuropsychiatric disorders, and its severity correlates with cognitive and attention deficits. There are no effective treatments, however, for stereotypy. Perturbation of serotonin (5-HT) neurotransmission contributes to stereotypy, suggesting that distinct 5-HT receptors may be pharmacotherapeutic targets to treat stereotypy and related neuropsychiatric symptoms. For example, preclinical studies indicate that 5-HT7 receptor activation corrects deficits in mouse models of Fragile X and Rett syndromes, and clinical trials for autism are underway with buspirone, a 5-HT1A partial agonist with relevant affinity at 5-HT7 receptors. Herein, we report the synthesis, in vitro molecular pharmacology, behavioral pharmacology, and pharmacokinetic parameters in mice after subcutaneous and oral administration of (+)-5-(2'-fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine ((+)-5-FPT), a new, dual partial agonist targeting both 5-HT7 (Ki = 5.8 nM, EC50 = 34 nM) and 5-HT1A (Ki = 22 nM, EC50 = 40 nM) receptors. Three unique, heterogeneous mouse models were used to assess the efficacy of (+)-5-FPT to reduce stereotypy: idiopathic jumping in C58/J mice, repetitive body rotations in C57BL/6J mice treated with the NMDA antagonist, MK-801, and repetitive head twitching in C57BL/6J mice treated with the 5-HT2 agonist, DOI. Systemic (+)-5-FPT potently and efficaciously reduced or eliminated stereotypy in each of the mouse models without altering locomotor behavior on its own, and additional tests showed that (+)-5-FPT, at the highest behaviorally active dose tested, enhanced social interaction and did not cause behaviors indicative of serotonin syndrome. These data suggest that (+)-5-FPT is a promising medication for treating stereotypy in psychiatric disorders.
Axl as a mediator of cellular growth and survival (2014)

The control of cellular growth and proliferation is key to the maintenance of homeostasis. Survival, proliferation, and arrest are regulated, in part, by Growth Arrest Specific 6 (Gas6) through binding to members of the TAM receptor tyrosine kinase family. Activation of the TAM receptors leads to downstream signaling through common kinases, but the exact mechanism within each cellular context varies and remains to be completely elucidated. Deregulation of the TAM family, due to its central role in mediating cellular proliferation, has been implicated in multiple diseases. Axl was cloned as the first TAM receptor in a search for genes involved in the progression of chronic to acute-phase leukemia, and has since been established as playing a critical role in the progression of cancer. The oncogenic nature of Axl is demonstrated through its activation of signaling pathways involved in proliferation, migration, inhibition of apoptosis, and therapeutic resistance. Despite its recent discovery, significant progress has been made in the development of effective clinical therapeutics targeting Axl. In order to accurately define the role of Axl in normal and diseased processes, it must be analyzed in a cell type-specific context.
UV ADHESIVE BONDING TECHNIQUES IN ROOM TEMPERATURE FOR PLASTIC LAB-ON-A-CHIPS (2003)

In this paper, a new UV adhesive bonding technique for the rapid and low-cost bonding of plastic biochips at room temperature has been developed and characterized. The spreading characteristics of biocompatible UV adhesive have been explored to optimize screen-printing around microchannels to achieve excellent sealing of microfluidic structures. We also have investigated the effect of surface modification on the bond strength of the UV adhesive. The results show that hydrophilic surface treatment enhances the bond strength, whereas hydrophobic treatment drastically reduces the bond strength.
[Lipid peroxidation and the phospholipid composition of the liver plasma membranes in rabbits in traumatic shock and their pharmacological correction]. (1990)

Changes in peroxidation of hepatic tissue lipids were studied in experiments on rabbits with Cannon's traumatic shock according to products reacting with thiobarbituric acid. The lipid composition of hepatocyte plasma membranes was studied by thin-layer chromatography. The levels of lipid peroxidation products and the ratio of phospholipid fractions changed depending on the stage of the process. Administration of superoxide dismutase in the initial periods of shock reduced the raised level of products reacting with thiobarbituric acid and maintained the ratio of phospholipid fractions in the hepatocyte plasma membrane at the initial level.
Analysis of the role of the bel and bet open reading frames of human foamy virus by using a new quantitative assay (1993)

We have constructed a BHK-21-derived indicator cell line containing a single integrated copy of the beta-galactosidase (beta-Gal) gene under control of the human foamy virus (HFV) long terminal repeat promoter (from -533 to +20). These foamy virus-activated beta-Gal expression (FAB) cells can be used in a quantitative assay to measure the infectious titer of HFV. Our results show that the FAB assay is 50 times more sensitive than determination of the virus titer by the end-point dilution method. Using the FAB assay, we have found that HFV can productively replicate in several erythroblastoid cell lines as well as in the Jurkat T-cell line. We have also examined the roles of bel2, bet, and bel3 in viral replication by constructing proviral HFV clones in which the reading frame of Bel2, Bet, or Bel3 is disrupted by placement of translation stop codons. Analysis of these mutants reveals that while the bel3 gene is not required for viral replication in vitro, mutations in the bel2 or bet gene decrease cell-free viral transmission approximately 10-fold.
The Judgment of Paris in the <i>Seege of Troye</i> (1942)

The present essay embodies a continuation of some previously published studies of the Middle English Seege (or Batayle) of Troye; it is therefore hardly necessary or advisable to present here a full summary of the large body of scholarly comment which this poem has aroused. Briefly, it has been established that the Seege of Troye is dependent on two principal sources: De Excidio Troiae of Dares Phrygius and the Roman de Troie of Benoit de Sainte-Maure; and that details from these two accounts are pretty thoroughly blended together in the English poem. There have been noted, however, a number of episodes—mostly concerned with the early lives of Paris and Achilles—which are not traceable either to Dares or to Benoit. At least one other source of some kind has therefore been regarded as a necessary postulate in order to account for the presence of these episodes in the Seege of Troye.