gebhart/patrepeval huggingface dataset:
Mesyl azide: a superior reagent for diazo transfer (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMesyl azide: a superior reagent for diazo transferDouglass F. Taber, Robert E. Ruckle Jr., and Michael J. HennessyCite this: J. Org. Chem. 1986, 51, 21, 4077–4078Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October 1986https://pubs.acs.org/doi/10.1021/jo00371a034https://doi.org/10.1021/jo00371a034research-articleACS PublicationsRequest reuse permissionsArticle Views2845Altmetric-Citations152LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cytokine Detection and Modulation in Acute Graft <i>vs</i>. Host Disease in Mice (1993)

A murine model for acute lethal graft vs. host disease (GVHD) was used to study the role that a number of cytokines play in the development of lethal GVHD. In this study we focused on the role of IL-1, IL-2, IL-4, IL-6, IFN-gamma and TNF-alpha. Lethally irradiated (C57BL x CBA)F1 mice were reconstituted either with 10(7) allogeneic BALB/c spleen cells or with a similar number of syngeneic cells, as a control. A significant rise in serum levels of IL-6, TNF-alpha and IFN-gamma levels was found in allogeneically reconstituted mice. This is in contrast to the syngeneic control group in which no rise was seen. Serum IL-2 and IL-4 levels were below the detection limit. In the supernatant of Con A stimulated spleen cells from allogeneically reconstituted mice IL-6, IFN-gamma and TNF-alpha concentrations were increased. The expression of mRNA for cytokines as detected by reverse transcription PCR was studied in spleen cells. In the allogeneic reconstituted mice the mRNA expression of IL-1alpha, IL-2, IL-6, IFN-gamma and TNF-alpha displayed faster kinetics compared with that in syngeneic reconstituted mice. The effect of treatment with recombinant cytokines, antibodies to cytokines and to cytokine receptors on the development of GVHD was investigated. Administration of recombinant IL-2 to allogeneically reconstituted mice strongly increased the morbidity and mortality whereas injection of IL-1alpha and TNF-alpha did not influence survival. Administration of antibodies against IL-2 or the IL-2 receptor decreased the morbidity and mortality. Anti-IL-6, anti-IFN-gamma, and anti-TNF-alpha mAB, on the other hand, did not affect the morbidity and mortality of GVHD. The results of this study suggest successive waves of cytokine-secreting cell populations consistent with the induction of an inflammatory response in the development of acute GVH disease.
An 8&#x00D7;8 row-column summing readout electronics for preclinical positron emission tomography scanners (2009)

This work presents a row/column summing readout electronics for an 8×8 silicon photomultiplier array. The summation circuit greatly reduces the number of electronic channels, which is desirable for pursuing higher resolution positron emission tomography scanners. By using a degenerated common source topology in the summation circuit, more fan-in is possible and therefore a greater reduction in the number of electronic channels can be achieved. The timing signal is retrieved from a common anode, which allows the use of a single fast-sampling analog to digital converter (ADC) for the timing channel and slower, lower power ADCs for the 64 spatial channels. Preliminary results of one row summation of the 8×8 readout electronics exhibited FWHM energy resolution of 17.8% and 18.3% with and without multiplexing, respectively. The measured timing resolution is 2.9ns FWHM.
The ERBB2/HER2 Receptor Differentially Interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 Domain Proteins (2001)

Identification of protein complexes associated with the ERBB2/HER2 receptor may help unravel the mechanisms of its activation and regulation in normal and pathological situations. Interactions between ERBB2/HER2 and Src homology 2 or phosphotyrosine binding domain signaling proteins have been extensively studied. We have identified ERBIN and PICK1 as new binding partners for ERBB2/HER2 that associate with its carboxyl-terminal sequence through a PDZ (PSD-95/DLG/ZO-1) domain. This peptide sequence acts as a dominant retention or targeting basolateral signal for receptors in epithelial cells. ERBIN belongs to the newly described LAP (LRR and PDZ) protein family, whose function is crucial in non vertebrates for epithelial homeostasis. Whereas ERBIN appears to locate ERBB2/HER2 to the basolateral epithelium, PICK1 is thought to be involved in the clustering of receptors. We show here that ERBIN and PICK1 bind to ERBB2/HER2 with different mechanisms, and we propose that these interactions are regulated in cells. Since ERBIN and PICK1 tend to oligomerize, further complexity of protein networks may participate in ERBB2/HER2 functions and specificity.
Generalized-marginal time-frequency distributions (1996)

We introduce a family of time-frequency (TF) distributions with generalized-marginals, i.e., beyond the time-domain and the frequency-domain marginals, in the sense that the projections of a TF distribution along one or more angles are equal to the magnitude squared of the fractional Fourier transforms of the signal. We present a necessary and sufficient condition for a TF distribution in the Cohen's class to satisfy generalized-marginals. We then modify the existing well-known TF distributions in the Cohen's class, such as Choi-Williams, Page distributions, so that the modified ones have generalized marginals. Numerical examples are presented to show that the proposed TF distributions have the advantages of both Wigner-Ville and other quadratic TF distributions which only have the conventional marginals. Moreover, they also indicate that the generalized-marginal TF distributions with proper marginals are more robust than the Wigner-Ville and the Choi-Williams distributions when signals contain additive noise.
Effects of selected cost-containment efforts: 1971-1993. (1992)

In this article, we review five health care cost-containment efforts from 1971 to the present and summarize key research findings on the effects of each on cost, quality, and access. These efforts include the Nixon Economic Stabilization Program (ESP), Carter-era hospital cost-containment efforts, Medicare hospital and physician payment, and State hospital ratesetting programs. The purpose of these efforts was to constrain the growth of health care spending by regulating or controlling prices or payments to providers of health care. Based on the experience of all five programs, we conclude with an analysis about the effectiveness of these kinds of initiatives.

This synthesis responds to the interest on the part of policymakers to better understand how current cost-control efforts can benefit from those of the past at both the Federal and State levels. In research spanning two decades, considerable knowledge has accumulated, though many outstanding questions remain. In general, this research shows that price controls can be effective but also that their effectiveness is constrained by provider responses to the incentives the controls create. Not surprisingly, research suggests that the most effective approaches also tend to have the broadest scopes: all-payer versus individual-payer systems, aggregate payment controls versus per service controls, and total payment limits (which address the base) versus only rate-of-increase limits. This greater effectiveness occurs because the more aggregate or all-encompassing approaches limit the ability of providers to offset cost pressures by raising prices to other payers or by increasing volume of care. Whether or not such controls merit serious consideration today and how they compare or may be combined with other strategies for cost containment are questions that exceed the scope of this article. The sources for this article, annotated and organized within each of the five cost-containment efforts, are listed in the Appendix.
Performance Investigation of Automatic Multiple SIM Card Cell Phones: Optimal Quality of Service Versus Minimum Cost in Mobile Communications (2012)

While looking at mobile phone communications, we realize that existing methods of switching between network providers are not satisfactory. Currently, when users want to switch between networks, they either have to own multiple cell phones or own the dual SIM card cell phones; where they have to select the network provider they wish to use whenever they are making or receiving calls. In this book we propose the use of of an algorithm that can be paramount in designing automatic multiple SIM card cell phones that are able to switch networks automatically based on optimal Quality of Service and low Cost. We hope that the reading will add value to the ever evolving area of mobile computing.
Effective Enhancement of Short-Chain-Length−Medium-Chain-Length Polyhydroxyalkanoate Copolymer Production by Coexpression of Genetically Engineered 3-Ketoacyl-Acyl-Carrier-Protein Synthase III (<i>f</i><i>abH</i>) and Polyhydroxyalkanoate Synthesis Genes (2004)

Polyhydroxyalkanoates (PHAs) are biodegradable polyesters that have a wide variety of physical properties dependent on the lengths of the pendant groups of the monomer units in the polymer. PHAs composed of mostly short-chain-length (SCL) monomers are often stiff and brittle, whereas PHAs composed of mostly medium-chain-length (MCL) monomers are elastomeric in nature. SCL-MCL PHA copolymers can have properties between the two states, dependent on the ratio of SCL and MCL monomers in the copolymer. It is desirable to elucidate new and low cost ways to produce PHA composed of mostly SCL monomer units with a small mol % of MCL monomers from renewable resources, since this type of SCL-MCL PHA copolymer has superior qualities compared to SCL homopolymer. To address this issue, we have created strains of recombinant E. coli capable of producing beta-ketothiolase (PhbA) and acetoacetyl-CoA synthase (PhbB) from Ralstonia eutropha, genetically engineered 3-ketoacyl-ACP synthase III (FabH) from Escherichia coli, and genetically engineered PHA synthases (PhaC) from Pseudomonas sp. 61-3 to enhance the production of SCL-MCL PHA copolymers from glucose. The cumulative effect of having two monomer-supplying pathways and genetically engineered PHA synthases resulted in higher accumulated amounts of SCL-MCL PHA copolymer from glucose. Polymers were isolated from two recombinant E. coli strains, the first harboring the phbAB, fabH(F87T), and phaC1(SCQM) genes and the second harboring the phbAB, fabH(F87W), and phaC1(SCQM) genes. The thermal and physical properties of the isolated polymers were characterized. It was found that even a very low mol % of MCL monomer in a SCL-MCL PHA copolymer had dramatic effects on the thermal properties of the copolymers.
Survival of <i>Lactobacillus reuteri</i> DSM 17938 and <i>Lactobacillus rhamnosus</i> GG in the Human Gastrointestinal Tract with Daily Consumption of a Low-Fat Probiotic Spread (2009)

Probiotics are live microorganisms which, when administered in adequate amounts, confer a health benefit on the host. Therefore, probiotic strains should be able to survive passage through the human gastrointestinal tract. Human gastrointestinal tract survival of probiotics in a low-fat spread matrix has, however, never been tested. The objective of this randomized, double-blind, placebo-controlled human intervention study was to test the human gastrointestinal tract survival of Lactobacillus reuteri DSM 17938 and Lactobacillus rhamnosus GG after daily consumption of a low-fat probiotic spread by using traditional culturing, as well as molecular methods. Forty-two healthy human volunteers were randomly assigned to one of three treatment groups provided with 20 g of placebo spread (n = 13), 20 g of spread with a target dose of 1 x 10(9) CFU of L. reuteri DSM 17938 (n = 13), or 20 g of spread with a target dose of 5 x 10(9) CFU of L. rhamnosus GG (n = 16) daily for 3 weeks. Fecal samples were obtained before and after the intervention period. A significant increase, compared to the baseline, in the recovery of viable probiotic lactobacilli in fecal samples was demonstrated after 3 weeks of daily consumption of the spread containing either L. reuteri DSM 17938 or L. rhamnosus GG by selective enumeration. In the placebo group, no increase was detected. The results of selective enumeration were supported by quantitative PCR, detecting a significant increase in DNA resulting from the probiotics after intervention. Overall, our results indicate for the first time that low-fat spread is a suitable carrier for these probiotic strains.
Effect of Low Temperature Storage on Sugar Concentrations and Chip Color of Certain Processing Potato Cultivars and Selections (1987)

ABSTRACT Two potato cultivars (Kennebec and Simcoe) and one selection (ND 860–2) were stored for 3 months at 4°, 9° and 11°C. ND 860–2 had the lowest sugar content at all storage temperatures, produced the lightest colored chips and was the only sample which gave acceptable colored chips directly from 4°C storage. In another study, three potato cultivars (Norchip, Simcoe and Onaway) and one selection (ND 860–2) were evaluated for sugar content and chip color during growth and harvest, two weeks prior and two weeks after foliar senescence, and stored under various time —‐ temperature regimes and upon reconditioning. ND 860–2 generally had the lowest levels of fructose, glucose and sucrose and Onaway had the highest. Storage at 5°C resulted in increases in the three sugars for all tubers, sucrose showing the most notable increase. ND 860–2 was the only sample to consistently produce acceptable colored chips directly from 5°C.
A Conceptual Approach for Integrating Phosphorus and Nitrogen Management at Watershed Scales (2000)

Abstract Since the late 1960s, point‐sources of water pollution have been reduced due to their ease of identification and treatment. As water quality problems remain and further point‐source measures become less cost‐effective, attention is directed toward reducing agricultural nonpoint‐sources of P and N. In the past, separate strategies for P and N were developed and implemented at farm or watershed scales. Because of differing biology, chemistry, and flow pathways of P and N in soil, these narrowly targeted strategies may lead to mixed results. In some cases, N management of manures has increased soil P and subsequent P enrichment of surface runoff, while no‐till has reduced P losses but increased nitrate leaching. Thus, an integrated approach to nutrient management is needed, with best management practices (BMPs) targeted to critical areas of a watershed that contribute most of the P and N exported. We have developed indices that identify critical sources and transport pathways controlling P and N export. These indices are applied to a mixed land use watershed in Pennsylvania. Areas most vulnerable to P loss are limited to small, well‐defined areas of the watershed (<20% of area) near the stream channel. In contrast to P, larger areas contribute to nitrate leaching and generally occur on the upper boundaries of the watershed (60%), where freely draining soils and high manure and fertilizer N applications are made. Thus, differing levels of nutrient management may be appropriate for different areas of a watershed.
STEROIDS. LV.<sup>1</sup> STEROIDAL SAPOGENINS. XXXV.<sup>2</sup> CHEMICAL INTRODUCTION OF THE 6β-HYDROXY GROUP INTO STEROIDAL Δ<sup>4</sup>-3-KETONES BY A TWO STEP SEQUENCE (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSTEROIDS. LV.1 STEROIDAL SAPOGENINS. XXXV.2 CHEMICAL INTRODUCTION OF THE 6β-HYDROXY GROUP INTO STEROIDAL Δ4-3-KETONES BY A TWO STEP SEQUENCEJ. ROMO, G. ROSENKRANZ, CARL DJERASSI, and FRANZ SONDHEIMERCite this: J. Org. Chem. 1954, 19, 9, 1509–1515Publication Date (Print):September 1, 1954Publication History Published online1 May 2002Published inissue 1 September 1954https://pubs.acs.org/doi/10.1021/jo01374a015https://doi.org/10.1021/jo01374a015research-articleACS PublicationsRequest reuse permissionsArticle Views285Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ESR1 Is Co-Expressed with Closely Adjacent Uncharacterised Genes Spanning a Breast Cancer Susceptibility Locus at 6q25.1 (2011)

Approximately 80% of human breast carcinomas present as oestrogen receptor α-positive (ER+ve) disease, and ER status is a critical factor in treatment decision-making. Recently, single nucleotide polymorphisms (SNPs) in the region immediately upstream of the ER gene (ESR1) on 6q25.1 have been associated with breast cancer risk. Our investigation of factors associated with the level of expression of ESR1 in ER+ve tumours has revealed unexpected associations between genes in this region and ESR1 expression that are important to consider in studies of the genetic causes of breast cancer risk. RNA from tumour biopsies taken from 104 postmenopausal women before and after 2 weeks treatment with an aromatase (oestrogen synthase) inhibitor was analyzed on Illumina 48K microarrays. Multiple-testing corrected Spearman correlation revealed that three previously uncharacterized open reading frames (ORFs) located immediately upstream of ESR1, C6ORF96, C6ORF97, and C6ORF211 were highly correlated with ESR1 (Rs = 0.67, 0.64, and 0.55 respectively, FDR<1 × 10(-7)). Publicly available datasets confirmed this relationship in other groups of ER+ve tumours. DNA copy number changes did not account for the correlations. The correlations were maintained in cultured cells. An ERα antagonist did not affect the ORFs' expression or their correlation with ESR1, suggesting their transcriptional co-activation is not directly mediated by ERα. siRNA inhibition of C6ORF211 suppressed proliferation in MCF7 cells, and C6ORF211 positively correlated with a proliferation metagene in tumours. In contrast, C6ORF97 expression correlated negatively with the metagene and predicted for improved disease-free survival in a tamoxifen-treated published dataset, independently of ESR1. Our observations suggest that some of the biological effects previously attributed to ER could be mediated and/or modified by these co-expressed genes. The co-expression and function of these genes may be important influences on the recently identified relationship between SNPs in this region and breast cancer risk.
Behavioral approaches to treatment of chronic pain: the inaccuracy of patient self-report measures. (1981)

This study was designed to examine the accuracy of patient self-report of physical activity and social behavior and a 3X daily log of pain intensity. Concomitantly, staff members made unobtrusive, hourly observations of patient activity and social behavior. Results showed that some patients report significantly lower levels of physical activity and social behavior than observed by staff despite reporting decreased levels of pain. These results suggest that the efficacy of therapeutic intervention is best determined by systematic observational data rather than patient self-report.
<b>Addition of Peroxides to Conjugated Olefins Catalyzed by Copper Salts</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition of Peroxides to Conjugated Olefins Catalyzed by Copper SaltsJay K. KochiCite this: J. Am. Chem. Soc. 1962, 84, 14, 2785–2793Publication Date (Print):July 1, 1962Publication History Published online1 May 2002Published inissue 1 July 1962https://pubs.acs.org/doi/10.1021/ja00873a029https://doi.org/10.1021/ja00873a029research-articleACS PublicationsRequest reuse permissionsArticle Views307Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A high performance cocurrent-flow heat pipe for heat recovery applications (1980)

By the introduction of a plate-and-tube separator assembly into a heat pipe vapor core, it has been demonstrated that axial transport capacity in reflux mode can be improved by up to a factor of 10. This improvement is largely the result of eliminating the countercurrent shear that commonly limits reflux heat pipe axial capacity. With benzene, axial heat fluxes up to 1800 W/sq cm were obtained in the temperature range 40 to 80 C, while heat flux densities up to 3000 W/sq cm were obtained with R-11 over the temperature range 40 to 80 C. These very high axial capacities compare favorably with liquid metal limits; the sonic limit for liquid sodium, for example, is 3000 W/sq cm at 657 C. Computational models developed for these cocurrent flow heat pipes agreed with experimental data within + or - 25%.