gebhart/patrepeval huggingface dataset:
Safety assessment of gadobenate dimeglumine (MultiHance®): Extended clinical experience from phase I studies to post‐marketing surveillance (2001)

Clinical trials completed by September 2000 on gadobenate dimeglumine (Gd-BOPTA; MultiHance) included 2540 adult and pediatric subjects that were administered this agent. For adult patient volunteers, the overall incidence of adverse events (AEs) was 19.8%, although marked study- and indication-related differences were apparent. Events potentially related to Gd-BOPTA administration were reported for 15.1% of adult patients. The vast majority of AEs were non-serious, mild, transient, and self-resolving. Headache, injection site reaction, nausea, taste perversion, and vasodilation were the most common AEs, reported with a frequency of between 1.0% and 2.6%. Serious AEs potentially related to Gd-BOPTA were reported for five (0.2%) patients overall. Controlled studies revealed no differences between Gd-BOPTA and other gadolinium chelates or placebo in the incidence and type of AEs. Similarly, no differences with respect to adult patients and/or comparator were noted in studies on pediatric subjects and subjects with renal or liver insufficiency. Post-marketing surveillance of approximately 100000 doses revealed an overall AE incidence of < 0.03% with serious AEs reported for < 0.005% of patients.
Single-dose and steady-state pharmacokinetics and pharmacodynamics of oxycodone in patients with cancer (1992)

The single-dose and steady-state pharmacokinetics and pharmacodynamics of oxycodone have been determined in patients with moderate to severe cancer pain. The mean +/- SD elimination half-life after single-dose administration of intravenous (4.6 mg to 9.1 mg) and oral (9.1 mg) oxycodone was 3.01 +/- 1.37 hours and 3.51 +/- 1.43 hours, respectively. After intravenous administration, the mean +/- SD volume of distribution was 211.9 +/- 186.6 L, and the mean +/- SD total plasma clearance was 48.6 +/- 26.5 L/hr. The mean absolute oral bioavailability of oxycodone was 87%, and the mean +/- SD volume of distribution after oral administration was 249.1 +/- 204.3 L. When administered orally as 10 mg oxycodone hydrochloride every 4 hours, there was no accumulation of oxycodone at steady state and the mean +/- SD steady-state concentration was 34.6 +/- 10.3 micrograms/L. Intravenous oxycodone produced a faster onset of pain relief than oxycodone tablets, but the duration of analgesia was approximately the same (4 hours). However, the incidence of side effects and their severity were significantly higher (p < 0.05) for intravenous oxycodone than for oxycodone tablets. The marked interindividual variation observed in the pharmacokinetics and pharmacodynamics of oxycodone in this study supports the need for individualized dosing regimens.
Phosphorylation of the SHC proteins on tyrosine correlates with the transformation of fibroblasts and erythroblasts by the v-sea tyrosine kinase. (1994)

The S13 avian erythroblastosis viral genome encodes an oncogenic tyrosine kinase, termed env-sea, that is capable of transforming fibroblasts and erythroblasts. Although the tyrosine kinase activity of the env-sea protein has been shown to be necessary for transformation, no substrates for this enzyme have been detected in vivo. Here we demonstrate that the recently described shc proteins are phosphorylated on tyrosine residues in both S13 transformed fibroblasts and erythroblasts. Furthermore, using an S13 temperature sensitive mutant, we show that the phosphorylation of the shc proteins occurs concomitantly with the activation of the tyrosine kinase activity of the env-sea protein. These observations make the phosphorylation of the shc proteins a good candidate for being involved in oncogenic signaling by the env-sea oncoprotein.
Group 5 transition metal imido complexes with dianionic guanidinate ligands displaying extended interactions (1999)

N,N′ ,N″–tri(isopropyl)guanidinate complexes of M(V) (M = Nb, Ta) bearing imido ligands represent unique examples of monoanionic and dianionic guanidinate complexes of these metals; single crystal X-ray analyses for two of the latter species, {[µ-(NPri)3C]2TaMe(NPri)}(Mg2Cl2)·4C6D6 and {(µ-η2:η2 (PriN)3C)Ta(NPri)Cl}2, exhibit unusual bonding modes involving all of the nitrogen centers of the ligand.
Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors (2019)

A significant unmet need for patients with multiple sclerosis (MS) is the lack of U.S. Food and Drug Administration (FDA)-approved remyelinating therapies. We have identified a compelling remyelinating agent, bazedoxifene (BZA), a European Medicines Agency (EMA)-approved (and FDA-approved in combination with conjugated estrogens) selective estrogen receptor (ER) modulator (SERM) that could move quickly from bench to bedside. This therapy stands out as a tolerable alternative to previously identified remyelinating agents and other candidates within this family. Using an unbiased high-throughput screen, with subsequent validation in both murine and human oligodendrocyte precursor cells (OPCs) and coculture systems, we find that BZA enhances differentiation of OPCs into functional oligodendrocytes. Using an <i>in vivo</i> murine model of focal demyelination, we find that BZA enhances OPC differentiation and remyelination. Of critical importance, we find that BZA acts independently of its presumed target, the ER, in both <i>in vitro</i> and <i>in vivo</i> systems. Using a massive computational data integration approach, we independently identify six possible candidate targets through which SERMs may mediate their effect on remyelination. Of particular interest, we identify EBP (encoding 3β-hydroxysteroid-Δ8,Δ7-isomerase), a key enzyme in the cholesterol biosynthesis pathway, which was previously implicated as a target for remyelination. These findings provide valuable insights into the implications for SERMs in remyelination for MS and hormonal research at large.<b>SIGNIFICANCE STATEMENT</b> Therapeutics targeted at remyelination failure, which results in axonal degeneration and ultimately disease progression, represent a large unmet need in the multiple sclerosis (MS) population. Here, we have validated a tolerable European Medicines Agency-approved (U.S. Food and Drug Administration-approved in combination with conjugated estrogens) selective estrogen receptor (ER) modulator (SERM), bazedoxifene (BZA), as a potent agent of oligodendrocyte precursor cell (OPC) differentiation and remyelination. SERMs, which were developed as nuclear ER-α and ER-β agonists/antagonists, have previously been implicated in remyelination and neuroprotection, following a heavy focus on estrogens with underwhelming and conflicting results. We show that nuclear ERs are not required for SERMs to mediate their potent effects on OPC differentiation and remyelination <i>in vivo</i> and highlight EBP, an enzyme in the cholesterol biosynthesis pathway that could potentially act as a target for SERMs.
Studies on Constituents of Medicinal Plants. VIII. The Stereochemistry of Paulownin and Isopaulownin (1966)

The stereochemistry of paulownin, isopaulownin, m.p. 132°, which was derived from paulownin with 20% EtOH-HCl or 5% HCOOH, d-sesamin and d-asarinin were elucidated as IIa, IIb, Ia and Ib by the analysis of their NMR spectra, respectively and consequently, epi-asarinin as Ic.
Ring Inversion and Bond Shift in Cyclooctatetraene Derivatives (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRing Inversion and Bond Shift in Cyclooctatetraene DerivativesF. A. L. Anet, A. J. R. Bourn, and Y. S. LinCite this: J. Am. Chem. Soc. 1964, 86, 17, 3576–3577Publication Date (Print):September 1, 1964Publication History Published online1 May 2002Published inissue 1 September 1964https://pubs.acs.org/doi/10.1021/ja01071a046https://doi.org/10.1021/ja01071a046research-articleACS PublicationsRequest reuse permissionsArticle Views634Altmetric-Citations137LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An On-Line Edge-Deletion Problem (1981)

article Free Access Share on An On-Line Edge-Deletion Problem Authors: Yossi Shiloach IBM Israel Scientific Center, Technion City, Haifa, Israel and Stanford University, Stanford, California IBM Israel Scientific Center, Technion City, Haifa, Israel and Stanford University, Stanford, CaliforniaView Profile , Shimon Even Computer Science Department, Technion, Haifa, Israel and University of California, Berkeley, California Computer Science Department, Technion, Haifa, Israel and University of California, Berkeley, CaliforniaView Profile Authors Info & Claims Journal of the ACMVolume 28Issue 1Jan. 1981 pp 1–4https://doi.org/10.1145/322234.322235Published:01 January 1981Publication History 189citation1,844DownloadsMetricsTotal Citations189Total Downloads1,844Last 12 Months172Last 6 weeks27 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
METHODS OF ASSESSING THE SPORICIDAL EFFICIENCY OF AN ULTRA‐HIGH‐TEMPERATURE MILK STERILIZING PLANT. III. LABORATORY DETERMINATIONS OF THE HEAT RESISTANCE OF SPORES OF <i>BACILLUS SUBTILIS</i> IN WATER AND IN MILK (1958)

SUMMARY: Thermal death curves for spores of Bacillus subtilis 786 have been determined in water and in milk. Generally a non‐logarithmic order of death was observed. Numbers of survivors were lower in milk than in water, suggesting that there may be inhibitory factors in UHT sterilized milk which affect the germination and/or subsequent growth of heated spores. The thermal death curves for spores suspended in milk yielded Q 10 values of about 30 in the range 110–120°. This is higher than the figures previously reported in the literature for R. subtilis spores. Spores of a number of strains of B. subtilis were compared with strain 786 and all gave high Q 10 values. The results obtained in this work have been used to predict the destruction of spores at higher temperatures in a UHT plant (Burton et al. 1958). The calculated values agree well with the results obtained in the plant by Franklin et al. (1958).
Microscale organic laboratory (1986)

Safety and the environment of the laboratory introduction to microscale laboratory equipment and technique determination of physical properties development of experimental technique preparative organic chemistry qualitative identification of organic compounds. Appendices: ultraviolet- visible spectroscopy introduction to the theory of infrared spectra nuclear magnetic resonance.
Phylobiochemical Characterization of Class-Ib Aspartate/Prephenate Aminotransferases Reveals Evolution of the Plant Arogenate Phenylalanine Pathway (2014)

The aromatic amino acid Phe is required for protein synthesis and serves as the precursor of abundant phenylpropanoid plant natural products. While Phe is synthesized from prephenate exclusively via a phenylpyruvate intermediate in model microbes, the alternative pathway via arogenate is predominant in plant Phe biosynthesis. However, the molecular and biochemical evolution of the plant arogenate pathway is currently unknown. Here, we conducted phylogenetically informed biochemical characterization of prephenate aminotransferases (PPA-ATs) that belong to class-Ib aspartate aminotransferases (AspAT Ibs) and catalyze the first committed step of the arogenate pathway in plants. Plant PPA-ATs and succeeding arogenate dehydratases (ADTs) were found to be most closely related to homologs from Chlorobi/Bacteroidetes bacteria. The Chlorobium tepidum PPA-AT and ADT homologs indeed efficiently converted prephenate and arogenate into arogenate and Phe, respectively. A subset of AspAT Ib enzymes exhibiting PPA-AT activity was further identified from both Plantae and prokaryotes and, together with site-directed mutagenesis, showed that Thr-84 and Lys-169 play key roles in specific recognition of dicarboxylic keto (prephenate) and amino (aspartate) acid substrates. The results suggest that, along with ADT, a gene encoding prephenate-specific PPA-AT was transferred from a Chlorobi/Bacteroidetes ancestor to a eukaryotic ancestor of Plantae, allowing efficient Phe and phenylpropanoid production via arogenate in plants today.
Application of a random regression model to genetic evaluations of test day yields and somatic cell scores in dairy cattle (2001)

Genetic evaluations using test day yields or somatic cell scores (SCS), instead of lactation records, in dairy cattle population have become a common practice in an increasing number of countries (Reents et al., 1998; Schaeffer et al., 2000; Stranden and Lidauer, 2001). Because random regression models make more realistic assumptions on the (co)variance structure of test day data than fixed regression models, research projects, such as parameter estimations for test day yields and SCS (Liu et al., 2000a; 2000b), have been conducted in Germany for implementing a random regression test day model (RRTDM) in national genetic evaluations. In this paper we present a new iteration scheme for solving mixed model equations (MME) of a RRTDM and a new reliability approximation method based on the concept of multiple trait effective daughter contribution (EDC) .
The Gap Filler Technology for Mobile Satellite System (2008)

To provide seamless broadband Internet and broadcasting services to passengers of high speed train via satellite link, gap filling is key technology to extend the service coverage in NLOS environment, so to speak, tunnel. The XpeedSAT system is a Ka/Ku band broadband mobile multimedia access system based on DVB-S2/DVB-RCS+M standard for satellite TV, video multicasting, Internet through wireless LAN. In this paper we introduce the various gap filling technologies and compare pros and cons. Finally we propose the gap filling method for NLOS environment in XpeedSAT system.
Ultra-miniature high-Q filters and duplexers using FBAR technology (2002)

An ultra-miniature PCS duplexer uses thin-film bulk wave acoustic resonator (FBAR) technology. FBAR resonators are made using aluminum nitride for the piezoelectric material and silicon as the substrate. It has better than -52 dB rejection for the receive (Rx) filter in the transmit (Tx) band and pass-band insertion losses are on the order of 2 dB (Tx) and 3 dB (Rx). Performance is comparable to that of much larger ceramic duplexers.
Direct activation of antigen-presenting cells is required for CD8 <sup>+</sup> T-cell priming and tumor vaccination (2011)

Successful priming of adaptive immune responses is crucially dependent on innate activation signals that convert resting antigen-presenting cells (APCs) into immunogenic ones. APCs expressing the relevant innate pattern recognition receptors can be directly activated by pathogen-associated molecular patterns (PAMPs) to become competent to prime T-cell responses. Alternatively, it has been suggested that APCs could be activated indirectly by proinflammatory mediators synthesized by PAMP-exposed cells. However, data obtained with CD4(+) T cells suggest that inflammatory signals often cannot substitute for direct pattern recognition in APC activation for the priming of T helper responses. To test whether the same is true for CD8(+) T cells, we studied cytotoxic T lymphocyte development in vitro and in mixed chimeric mice in which coexisting APCs can either present a preprocessed model antigen or directly recognize a given PAMP, but not both. We show that indirectly activated APCs promote antigen-specific proliferation of naïve CD8(+) T cells but fail to support their survival and cytotoxic T lymphocyte differentiation. Furthermore, CD8(+) T cells primed by indirectly activated APCs are unable to reject tumors. Thus, inflammation cannot substitute for direct recognition of single PAMPs in CD8(+) T-cell priming. These findings have important practical implications for vaccine design, indicating that adjuvants must be judiciously chosen to trigger the relevant pattern recognition receptors in APCs.
Displaytool: An Image Display Utility For Sun Workstations (1988)

Recent developments in microcomputer technology have resulted in the widespread availability of workstations with large memories, high processor speeds, and graphical displays. Because of the large number of applications in computer aided design and document preparation, most of the utilities which have been written for these workstations are designed to display wire-frame figures, shaded graphics models, or text. Such tools are not suited to the special needs of image processing. This paper describes displaytool, a utility which provides a window-based image display environment tailored for image processing. Displaytool supports subplane selection for multidimensional images; a large pixel value range, including negative values; interactive manipulation of colormaps for continuous contrast and brightness adjustment; statistical image summaries with graphical histogram display; interactive image subtraction; and simultaneous display of multiple images with arbitrary overlapping. The program runs under UN/X1 on Sun workstations within the Suntool window environment.
Student Attendance Management System with Bluetooth Low Energy Beacon and Android Devices (2015)

An attendance management system is developed such that the students present in the class can register their attendance by scanning their student ID cards over not only the teacher's terminal device but also their own personal Android devices. This system solves the problem with the conventional system that it took a long time for all the students to scan their cards by a single terminal device. In order to spoil cheating students who try to resister their attendance illegally from outside the classroom, we employ a BLE (Bluetooth Low Energy) beacon device to transmit a magic number necessary for proper registration within the classroom.
Disposition and Metabolic Profiles of [ <sup>14</sup> C]Viramidine and [ <sup>14</sup> C]Ribavirin in Rat and Monkey Red Blood Cells and Liver (2004)

The disposition and metabolic profiles of [14C]viramidine and [14C]ribavirin were compared in rat and monkey red blood cells and liver. Our data reveal that the total ribavirin-related components (ribavirin plus its mono-, di-, and triphosphate metabolites) may account for most of the drug in monkey liver following prolonged oral administration of viramidine.
Etiprednol dicloacetate, a new soft glucocorticoid drug candidate. Development of chemistry. (2004)

During development of chemistry of the soft drug candidate etiprednol dicloacetate (BNP-166) 1) optimization studies on the three-step chemical synthesis resulted in a process that could be scaled-up to the kg level, 2) the impurity profile was determined, 3) synthetic routes were developed for the preparation of the radiolabeled target compound, and 4) a series of hydroxylated metabolites was prepared.
Steady-state thermally annealed GaAs with room-temperature-implanted Si (1980)

Semi-insulating Cr-doped single-crystal GaAs samples were implanted at room temperature with 300-keV Si ions in the dose range of (0.17–2.0)×1015 cm−2 and were subsequently steady-state annealed at 900 and 950 °C for 30 min in a H2 ambient with a Si3N4 coating. Differential Hall measurements showed that an upper threshold of about 2×1018/cm3 exists for the free-electron concentration. The as-implanted atomic-Si profile measured by SIMS follows the theoretical prediction, but is altered during annealing. The Cr distribution also changes, and a band of dislocation loops ∼2–3 kÅ wide is revealed by cross-sectional TEM at a mean depth of Rp∼3 kÅ. Incomplete electrical activation of the Si is shown to be the primary cause for the effect.
An Application of Artificial Neural Networks. Simultaneous Determination of the Concentration of Sulfur Dioxide and Relative Humidity with a Single Coated Piezoelectric Crystal (1997)

A piezoelectric quartz crystal coated with TEA was applied to the simultaneous determination of the concentration of sulfur dioxide and relative humidity. According to the different dynamic desorption process of sulfur dioxide and water vapor on the TEA coating, the ANN method was used to analyze the frequency response data of the crystal at different times. The concentrations of sulfur dioxide and relative humidity can be calculated simultaneously. The average relative errors were less than 10.09% for sulfur dioxide and 11.3% for relative humidity.
Integrating Legacy Forwarding Environment to OpenFlow/SDN Control Plane (2013)

Currently, there is a philosophical problem that arises between the real need for current support to OpenFlow and legacy network infrastructure. Among them, the legacy networking has not been compatible with OpenFlow network, and for that, it needs to be replaced or a few cases upgraded, as a consequence there are additional spending with new equipment OpenFlow-based. This paper introduces a proposal of hybrid SDN solution based on OpenFlow protocol and called of LegacyFlow, which is able to control Legacy equipment (non-OpenFlow) through OpenFlow protocol 1.0. Results show that it is possible used the LegacyFlow together with OpenFlow switches keeping a good performance time with OpenFlow application.
Quantitative Determination of Vapor-Phase Compound A in Sevoflurane Anesthesia Using Gas Chromatography–Mass Spectrometry (2001)

A simple, fully automated, and reliable quantitative analytical method for determination of compound A in air was developed. A solution was established for sampling, calibration, and chromatographic separation of volatiles in an area complicated by limited availability of sample volume and low concentrations of the analyte.
Transition‐Metal‐Catalyzed Selective Cyclization Strategy to 2‐Substituted Benzofurans and Indoles en Route to the Oxa Analogues of Isocryptolepine (2014)

Abstract A selective catalytic route to benzofurans and indoles from similar starting materials has been developed. A two‐step protocol that involves a transition‐metal‐catalyzed domino Sonogashira coupling between 2‐ethynylanilines and 2‐iodophenols followed by selective O ‐ and N ‐cyclizations afforded 2‐(benzofuran‐2‐yl)anilines and 2‐(indol‐2‐yl)phenols, respectively. The 2‐(benzofuran‐2‐yl)anilines were further utilized in a Lewis acid catalyzed Pictet–Spengler‐type cyclization to prepare the oxa analogues of isocryptolepine.
The chemistry of <i>Eremophila</i> spp. XXI. Structural study of a new eremane diterpene (1984)

The structure of a new eremane diterpene isolated from Eremophila cuneifolia Kraenzlin has been determined by X-ray crystallographic methods. The conversion of this diterpene into sesquiterpeneswith the same tricyclic skeleton is described.
Studies on penem antibiotics. I. Synthesis and in vitro activity of novel 2-chiral substituted penems. (1988)

Etude d'acides hydroxy-1' ethyl-6 peneme-2carboxyliques substitues en 2 par: perhydrofuryl-2 ou -3, oxo-5 perhydro furyl-2, perhydropyrannyl-2, dioxanne-1,4yl, acetoxy-1' ethyl, methoxy-1' ethyl, furyl-2 ou -3, ethoxymethyl, fluoro-2' ethoxymethyl et ethylthiomethyl