gebhart/patrepeval huggingface dataset:
Migration of a Phthalate Ester Plasticizer from Polyvinyl Chloride Blood Bags into Stored Human Blood and Its Localization in Human Tissues (1972)

A plasticizer, di-2-ethylhexyl phthalate, was found to be extracted from polyvinyl chloride plastic blood bags by both human and dog blood stored at 4°C at a rate of 0.25 ± 0.03 mg per 100 ml per day. Plasticizer was found in both the lipid-containing and lipid-free fractions of plasma whereas red cells contained only minor amounts. Seven of 12 lung-tissue samples taken at autopsy from patients who had received transfusions of stored blood contained detectable amounts of plasticizer. One patient, after open-heart surgery, excreted a urinary metabolite of the plasticizer in excess of the amount calculated to have been received in the transfused blood. The additional metabolite possibly came from plasticizer extracted from the polyvinyl chloride tubing of the cardiopulmonary unit. Although the toxicologic implications of these observations are not currently known, it is suggested that plastic formulations that do not contribute any extractable materials to blood or its fractions be developed.
Chemiluminescence from oxygen atom-hydrazine flames (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemiluminescence from oxygen atom-hydrazine flamesKarl Heinz Becker and Kyle D. BayesCite this: J. Phys. Chem. 1967, 71, 2, 371–377Publication Date (Print):January 1, 1967Publication History Published online1 May 2002Published inissue 1 January 1967https://pubs.acs.org/doi/10.1021/j100861a025https://doi.org/10.1021/j100861a025research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Dravet syndrome as epileptic encephalopathy: evidence from long-term course and neuropathology (2011)

Dravet syndrome is an epilepsy syndrome of infantile onset, frequently caused by SCN1A mutations or deletions. Its prevalence, long-term evolution in adults and neuropathology are not well known. We identified a series of 22 adult patients, including three adult post-mortem cases with Dravet syndrome. For all patients, we reviewed the clinical history, seizure types and frequency, antiepileptic drugs, cognitive, social and functional outcome and results of investigations. A systematic neuropathology study was performed, with post-mortem material from three adult cases with Dravet syndrome, in comparison with controls and a range of relevant paediatric tissue. Twenty-two adults with Dravet syndrome, 10 female, were included, median age 39 years (range 20-66). SCN1A structural variation was found in 60% of the adult Dravet patients tested, including one post-mortem case with DNA extracted from brain tissue. Novel mutations were described for 11 adult patients; one patient had three SCN1A mutations. Features of Dravet syndrome in adulthood include multiple seizure types despite polytherapy, and age-dependent evolution in seizure semiology and electroencephalographic pattern. Fever sensitivity persisted through adulthood in 11 cases. Neurological decline occurred in adulthood with cognitive and motor deterioration. Dysphagia may develop in or after the fourth decade of life, leading to significant morbidity, or death. The correct diagnosis at an older age made an impact at several levels. Treatment changes improved seizure control even after years of drug resistance in all three cases with sufficient follow-up after drug changes were instituted; better control led to significant improvement in cognitive performance and quality of life in adulthood in two cases. There was no histopathological hallmark feature of Dravet syndrome in this series. Strikingly, there was remarkable preservation of neurons and interneurons in the neocortex and hippocampi of Dravet adult post-mortem cases. Our study provides evidence that Dravet syndrome is at least in part an epileptic encephalopathy.
Arthrodesis for failed knee arthroplasty. A report of 20 cases (1985)

Twenty consecutive patients treated by arthrodesis for failed knee arthroplasty are reviewed. Eight hinged, five stabilised and seven compartmental prostheses were removed, for infection (15 cases), loosening (4) and instability (1). One patient refused a second-stage operation but the remainder gained sound fusion. Infected knees had a two-stage procedure with temporary insertion of gentamicin-loaded beads after removal of the prosthesis; all infections healed. Six arthrodeses using a Hoffmann-Vidal external fixator resulted in two temporary failures. One Ace-Fischer external fixation was successful. Of 10 primary attempts at arthrodesis with an intramedullary Küntscher nail, nine were successful; the tenth fused after two more attempts by the same method. The two failures of external fixation and two failures after Charnley single-frame compression done elsewhere were successfully fused with intramedullary nails. Delayed union in three cases fused after prolonged fixation and repeated bone grafts. The indications for and methods of arthrodesis after failed knee arthroplasty are discussed.
Cell-Mediated Immune Response to Tuberculosis Antigens: Comparison of Skin Testing and Measurement of In Vitro Gamma Interferon Production in Whole-Blood Culture (2001)

Although delayed-type hypersensitivity skin testing with tuberculin purified protein derivative (PPD) is the standard for tuberculosis screening, its variability suggests the need for a more sensitive, noninvasive test. An in vitro whole-blood assay has been proposed as an alternative. Using health care worker volunteers, we confirmed the correlation between PPD skin test (PPD-ST) results (positive, induration of >15 mm) and a standardized gamma interferon (IFN-gamma) assay, QuantiFERON-TB (Q-IFN), manufactured by CSL Biosciences in Australia, and we evaluated Mycobacterium tuberculosis culture subfractions as potential substitutes for PPD. Twenty healthy volunteers with positive PPD-ST results and 20 PPD-ST-negative controls were enrolled. Whole blood was cultured with human PPD antigens (HuPPD), Mycobacterium avium complex (MAC) PPD, phytohemagglutinin (PHA), and four M. tuberculosis culture subfractions: low-molecular-weight culture, filtrate, culture filtrate without lipoarabinomannan, soluble cell wall proteins, and cytosolic proteins, all developed from M. tuberculosis strain H(37)RV. Secretion of IFN-gamma (expressed as international units per milliliter) was measured by an enzyme immunoassay. The PPD or subculture fraction response as a percentage of the PHA response was used to determine positivity. Sixteen of 20 PPD-ST-positive individuals were classified as M. tuberculosis positive by Q-IFN, and 1 was classified as MAC positive. Sixteen of 20 PPD-ST-negative individuals were M. tuberculosis negative by Q-IFN, 2 were MAC positive, and 2 were M. tuberculosis positive. The tuberculosis culture subfractions stimulated IFN-gamma production in PPD-ST-positive volunteers, and significant differences could be seen between the two PPD-ST groups with all subfractions except soluble cell wall protein; however, the response was variable and no better than the Q-IFN PPD. The agreement between the Q-IFN test and the PPD-ST was good (Cohen's kappa = 0.73). The Q-IFN assay can be a useful tool in further studies of immune responses to M. tuberculosis antigens.
Binding of Ligands and Activation of Transcription by Nuclear Receptors (2001)

Nuclear receptors (NRs) form a superfamily of ligand-inducible transcription factors composed of several domains. Recent structural studies focused on domain E, which harbors the ligand-binding site and the ligand-dependent transcription activation function AF-2. Structures of single representatives in an increasing number of various complexes as well as new structures of further NRs addressed issues such as discrimination of ligands, superagonism, isotype specificity, and partial agonism. Until today, one unique transcriptionally active form of domain E was determined; however, divergent tertiary structures of apo-forms and transcriptionally inactive forms are known. Thus, recent results link the transformation of NRs upon ligand binding to principles of protein folding. Furthermore, the ensemble of NR structures, including those of DNA-binding domains, provides one of the foundations for the understanding of interactions with transcription intermediary factors up to the characterization of the link between NR complexes and the basal transcriptional machinery at the structural level.
Metallinduzierte CC‐Einfachbindungsspaltung 5,5‐dialkylsubstituierter Cyclopentadiene durch Metallcarbonylkomplexe der 6. Nebengruppe (1980)

Abstract Die Umsetzung von Spiroheptadien 1 , 1‐Methylspiroheptadien 13 , 1‐Vinylspiroheptadien 20 , Spirononadien 7 und offenkettigen 5,5‐Dialkylcyclopentadienen 10 mit Molybdän‐ und Wolframkomplexen des Typs M(CO) 3 L 3 führt unter Spaltung einer CC‐Einfachbindung zu σ‐Alkyl‐bzw. σ‐Acyl‐σ‐cyclopentadienyl‐Komplexen dieser Metalle. Mit analogen Chromkomplexen können solche Produkte nicht isoliert werden. Die Umwandlungen der in 1‐Stellung substituierten Spiroheptadiene 13 und 20 zeigen, daß eine Methylgruppe die Öffnung der benachbarten CC‐Bindung des Dreirings im Spiroheptadien behindert, während eine Vinylgruppe diese fördert. Kreuzungsversuche mit 5,5‐Dialkylcyclopentadienen 10 weisen auf einen intramolekularen Verlauf der Wanderung von Alkylgruppen vom Liganden zum Metall hin.
The sympathetic nervous system through the ages: from Thomas Willis to resistant hypertension (2011)

The 17th century London neuroanatomical school headed by Thomas Willis provided us with the first identifiable images of the sympathetic nervous system. Nineteenth century giants of European physiology (Bernard, Waller and Brown-Sequard) identified these as the 'pressor nerves'. Von Euler's demonstration that the sympathetic transmitter was noradrenaline brought the field into the modern era. The development of ganglion-blocking drugs by Paton, whose name this review commemorates, allowed comprehensive pharmacological antagonism of this system in patients. With the development of contemporary techniques for recording from human sympathetic nerves and quantifying rates of noradrenaline release, the sympathetic nervous system became accessible to clinical scientists investigating possible contributions to cardiovascular and other diseases. Sympathetic nervous system responses typically are regionally differentiated, with activation in one outflow sometimes accompanying no change or sympathetic inhibition in another. Regional sympathetic activity is best studied in humans by recording from postganglionic sympathetic efferents (multi-unit or single-fibre recording) and by isotope dilution-derived measurement of organ-specific noradrenaline release to plasma from sympathetic nerves (regional 'noradrenaline spillover'). With the application of these techniques, evidence has been assembled in the past three decades which indicates that sympathetic nervous system activation is crucial in the development of cardiovascular disorders, most notably heart failure and essential hypertension. An important goal for clinical scientists is translation of knowledge of pathophysiology, such as this, into better treatment for patients. The achievement of this 'mechanisms to management' transition is mature in cardiac failure, with knowledge of cardiac neural pathophysiology having led to introduction of β-adrenergic blockers, an effective therapy. Perhaps we are now on the cusp of effective translation in patients with essential hypertension, with recent successful testing of selective catheter-based renal sympathetic nerve ablation in patients with resistant hypertension, an intervention firmly based on prior demonstration in them of activation of the renal sympathetic outflow.
When the price is right (2013)

In an era of 108% annual growth in demand for mobile data and $10/GB overage fees, Internet Service Providers (ISPs) are experiencing severe congestion and in turn are hurting consumers with aggressive pricing measures. But smarter practices, such as time-dependent pricing (TDP), reward users for shifting their non-critical demand to off-peak hours and can potentially benefit both users and ISPs. Although dynamic TDP ideas have existed for many years, dynamic pricing for mobile data is only now gaining interest among ISPs. Yet TDP plans require not only systems engineering but also an understanding of economic incentives, user behavior and interface design. In particular, the HCI aspects of communicating price feedback signals from the network and the response of mobile data users need to be studied in the real world. But investigating these issues by deploying a virtual TDP data plan for real ISP customers is challenging and rarely explored. To this end, we carried out the first TDP trial for mobile data in the US with 10 families. We describe the insights gained from the trial, which can help the HCI community as well as ISPs, app developers and designers create tools that empower users to better control their usage and save on their monthly bills, while also alleviating network congestion.
Biotin-Labeled Synthetic Oligodeoxyribonucleotides: Chemical Synthesis and Uses as Hybridization Probes (1985)

Abstract Several biotinylated synthetic oligodeoxyribonucleotides have been selectively prepared by a simple and efficient chemical method. This procedure allows the specific and covalent coupling of one biotinmoiety to any 5′-kinased unprotected oliqodeoxyribonucleotide through an aminoalkylphosphoramide linker arm. The reactions are performed in aqueous solutions on unprotected oligonucleotides and proceed cleanly with good yields. This method is insensitive of the length of the polynucleotide, of the nucleotide sequence and of the nature of the 5′-terminal nucleotide.
Open-loop peak voltage feedforward control of PWM buck converter (2000)

DC and small-signal analyses are given for an open-loop buck pulse-width modulated (PWM) DC-DC converter with peak-voltage-modulation (PVM) feedforward control. A DC model is used to derive the DC input-to-output voltage transfer function taking into account parasitic components, such as the MOSFET on-resistance, diode forward resistance, and diode offset voltage. A small-signal model is used to derive the audio susceptibility and the input impedance. It is shown that ideally the audio susceptibility is zero and the input impedance is frequency independent and negative for the buck converter with PVM feedforward control.
Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parameters (2009)

This described model will provide valuable guidance on prognosis after curative surgery for HCC in clinical practice. The adaptive nature allows easy accommodation for future new biomarker inputs, and it may serve as the foundation for future modeling and prediction for HCC prognosis after surgical treatment.
CyCADA: Cycle-Consistent Adversarial Domain Adaptation (2017)

Domain adaptation is critical for success in new, unseen environments. Adversarial adaptation models applied in feature spaces discover domain invariant representations, but are difficult to visualize and sometimes fail to capture pixel-level and low-level domain shifts. Recent work has shown that generative adversarial networks combined with cycle-consistency constraints are surprisingly effective at mapping images between domains, even without the use of aligned image pairs. We propose a novel discriminatively-trained Cycle-Consistent Adversarial Domain Adaptation model. CyCADA adapts representations at both the pixel-level and feature-level, enforces cycle-consistency while leveraging a task loss, and does not require aligned pairs. Our model can be applied in a variety of visual recognition and prediction settings. We show new state-of-the-art results across multiple adaptation tasks, including digit classification and semantic segmentation of road scenes demonstrating transfer from synthetic to real world domains.
Potential of the polymer poly-[2-(tert-butylamino) methylstyrene] as antimicrobial packaging material for meat products (2016)

Poly(TBAMS) bears a high potential to increase safety and shelf life of meat products.
Using 2-Aminopurine Fluorescence and Mutational Analysis to Demonstrate an Active Role of Bacteriophage T4 DNA Polymerase in Strand Separation Required for 3′→ 5′-Exonuclease Activity (1996)

The fluorescence of 2-aminopurine deoxynucleotide positioned in a 3'-terminal mismatch was used to evaluate the pre-steady state kinetics of the 3' --> 5' exonuclease activity of bacteriophage T4 DNA polymerase on defined DNA substrates. DNA substrates with one, two, or three preformed terminal mispairs simulated increasing degrees of strand separation at a primer terminus. The effects of base pair stability and local DNA sequence on excision rates were investigated by using DNA substrates that were either relatively G + C- or A + T-rich. The importance of strand separation as a prerequisite to the hydrolysis of a terminal nucleotide was demonstrated by using a unique mutant DNA polymerase that could degrade single-stranded but not double-stranded DNA, unless two or more 3'-terminal nucleotides were unpaired. Our results led us to conclude that the reduced exonuclease activity of this mutant DNA polymerase on duplex DNA substrates is due to a defect in melting the primer terminus in preparation for the excision reaction. The mutated amino acid (serine substitution for glycine at codon 255) resides in a critical loop structure determined from a crystallographic study of an amino-terminal fragment of T4 DNA polymerase. These results suggest an active role for amino acid residues in the exonuclease domain of the T4 DNA polymerase in the strand separation step.
Enhanced Security Scheme for Managing Heterogeneous Server Platforms (2006)

In this paper, we propose enhanced security scheme for managing heterogeneous server platforms. We apply fault tolerant architecture to basic remote server management model for providing security enhancement. This security enhancement includes several security services such as authentication, integrity, confidentiality, role based access control, and single-sign on. The traditional management methods cannot obtain these strong security services. Also, we present implementation results to verify functionality of the proposed scheme and demonstrate the performance of certificate validation that occupy most of total latency
A new reference model for steer-by-wire applications with embedded vehicle dynamics (2006)

We propose a new a reference model for steer-by-wire applications. The model accounts for force reflection and vehicle dynamics interaction. In particular, a bicycle model including the front axle kinematic and lateral contact forces, are explicitly accounted during the model tuning. The model is completed with a virtual feedback force, designed from an optimal feedback control loop, that aims at imposing a particular steering behavior improving the vehicle handling characteristics. This results in a model that is (vehicle) velocity dependent with good stability properties. The model keeps such good properties even in presence of unmodelled tire-road dynamics, and under certain parameter variation.
A diode-pumped, high gain, planar waveguide, Nd:Y3Al5O12 amplifier (1997)

We report the use of a 5-mm-long planar Nd:yttrium aluminum garnet waveguide grown by liquid-phase epitaxy as an amplifier at 1.064 μm. In a double-pass configuration pumped by a 1.2 W diode laser, small signal gains of 686 (28 dB) have been observed and efficient power extraction demonstrated with output powers of up to 290 mW being obtained.
Anti-phase direct bonding and its application to the fabrication of InP-based 1.55 μm wavelength lasers on GaAs substrates (1995)

We propose anti-phase direct bonding and report on the first demonstration of its application to device fabrication. Cross-sectional observation by high-resolution transmission electron microscope showed that InP and GaAs wafers bonded at the atomic level and the misfit dislocations were localized at the bonding interface. Then InP-based 1.55 μm wavelength lasers were fabricated on GaAs. The performance of the lasers was approximately equal to that of the lasers formed by in-phase direct bonding. Moreover, stable operation was possible for more than 1000 h at 50 °C.
Honest to goodness food (1971)

The recent public interest in date marking of food has focused attention on a small group of people whose activities are important to all of us, but who rarely come into the limelight. They are the members of the Food Standards Committee.
Online Learning of Approximate Dependency Parsing Algorithms. (2006)

In this paper we extend the maximum spanning tree (MST) dependency parsing framework of McDonald et al. (2005c) to incorporate higher-order feature representations and allow dependency structures with multiple parents per word. We show that those extensions can make the MST framework computationally intractable, but that the intractability can be circumvented with new approximate parsing algorithms. We conclude with experiments showing that discriminative online learning using those approximate algorithms achieves the best reported parsing accuracy for Czech and Danish. 1
Comparison of Core Petrophysical Properties Between Low-Permeability Sandstone Reservoirs: Eastern U.S. Medina Group and Western U.S. Mesaverde Group and Frontier Formation (2000)

Abstract Comparison of petrophysical properties between Eastern U.S. Silurian-age sandstones and Western U.S. Cretaceous-age sandstones illustrates the universality of certain low-permeability reservoir properties. In the Medina insitu porosities are generally within 97% of routine porosities and in Mesaverde-Frontier are approximately 0.8 porosity percent less than routine porosities. In both groups insitu Klinkenberg permeability (ki) exhibits an increasing difference from routine air permeability with decreasing permeability. Both groups of low-permeability sandstones exhibit very similar decrease in "irreducible" water saturation (Siw) with increasing ki. However, lithologic variations that are related primarily to grain size and shaliness cause variance in Siw at any given permeability. Both eastern and western low-permeability sandstones exhibit sharp decrease in gas relative permeability (krg,Siw) with increasing Siw. The krg,Siw values are generally less than 5% at Siw greater than 60%. Although average krgSiw is low and average Siw is high, these sandstones typically produce water-free gas. Analysis of cumulative flow capacity in wells in both regions indicates that a significant fraction of total flow capacity often comes from a few, thin, higher permeability intervals within generally low-permeability sandstone. Although storage capacity declines with decreasing permeability due to increasing Siw, low-permeability intervals still represent a significant fraction of total storage.