gebhart/patrepeval huggingface dataset:
Synthesis of Thiol-Derivatized Porphyrin Dimers and Trimers for Studies of Architectural Effects on Multibit Information Storage (2000)

We present the rational design and synthesis of multiporphyrin arrays containing thiol-derivatized linkers for the purpose of multibit molecular information storage. Porphyrin dimers and trimers were synthesized by the Pd-mediated coupling of iodo-substituted and ethynyl-substituted porphyrin building blocks in 5-51% yields. Each porphyrin dimer bears one S-acetylthio group. The architecture of the trimers incorporates a trans-substituted porphyrin (central) bearing two S-acetylthio groups and two diphenylethyne-linked porphyrins (wings) in a trans geometry. The central porphyrin and the wing porphyrins bear distinct substituents and central metals, thereby affording different oxidation potentials. The S-acetylthio groups provide a means for attachment of the arrays to an electroactive surface. The dimers are designed for vertical orientation on an electroactive surface while the trimers are designed for horizontal orientation of the central porphyrin. Altogether seven different arrays were synthesized. Each array forms a self-assembled monolayer (SAM) on gold via in situ cleavage of the S-acetyl protecting group. The SAM of each array is electrochemically robust and exhibits multiple, reversible oxidation waves. In general, however, the trimeric arrays appear to form more highly ordered monolayers that exhibit sharper, better-defined redox features.
Microwave Measurement of High-Dielectric- Constant Materials (1966)

A particularly severe source of error in the microwave measurement of high dielectric constants has been the presence of small air gaps between dielectric surfaces and metal walls. In this paper, two precise measurement techniques are described that eliminate the effect of air gaps through the use of resonant modes, for which E/sub n/=0 at the dielectric-to-metal interface. In one method a cylindrical sample is resonated within a closely fitting circular waveguide, and in the other a cylindrical sample is placed at the center of a radial waveguide. Both methods utilize a circular-electric-mode whose electric field is parallel to the metal walls. The waveguides are dimensioned to be cut off in their air regions at the resonant frequency of the dielectric sample. Formulas yield /spl epsi//sub r/ as a function of the resonant frequency, and of diameter and length of the dielectric cylinder. Measured data on samples having /spl epsi//sub r/ /spl ap/ 85 show the two methods to agree within a few tenths of one percent. The accuracy of the methods is on the order of 0.5 percent maximum error and 0.2 percent probable error when /spl int//sub 0/ is measured within 0.1 percent and D and L within 0.0005 inch (for D/spl ap/ 0.3 inch and L /spl ap/0.1 inch).
Spatiotemporal Effects of Syncytial Heterogeneities on Cardiac Far‐Field Excitations During Monophasic and Biphasic Shocks (1998)

This study provides strong additional support for and understanding of the syncytial heterogeneity hypothesis and its manifested properties. Furthermore, these results predict that syncytial heterogeneities of even modest proportions could represent a significant mechanism contributing to the far-field excitation process.
Minimizing the number of one-paths in BDDs by an evolutionary algorithm (2004)

Ordered binary decision diagrams (BDDs) are used in VLSI CAD, especially for the canonical representation of Boolean functions. In the last decade, the method of choice for optimizing this data structure was minimizing the number of nodes in the associated graph. However, recent works have shown that the number of paths is also important. In this work, minimizing the number of one-paths of BDDs is accomplished by an evolutionary algorithm (EA) acting on the permutation of variables. The optimal operator weights for the EA were determined by a parameter study. Experimental results demonstrate the efficiency of our approach.
Rumination time around calving: An early signal to detect cows at greater risk of disease (2014)

The main objective of this experiment was to evaluate the use of rumination time (RT) during the peripartum period as a tool for early disease detection. The study was carried out in an experimental freestall barn and involved 23 Italian Friesian cows (9 primiparous and 14 multiparous). The RT was continuously recorded by using an automatic system (Hr-Tag, SCR Engineers Ltd., Netanya, Israel), and data were summarized in 2-h intervals. Blood samples were collected from 30 d before calving to 42 d in milk (DIM) to assess biochemical indicators related to energy, protein, and mineral metabolism, as well as markers of inflammation and some enzyme activities. The liver functionality index, which includes some negative acute-phase proteins and related parameters (albumin, cholesterol, and bilirubin), was used to evaluate the severity of inflammatory conditions occurring around calving. The cows were retrospectively categorized according to RT observed between 3 and 6 DIM into those with the lowest (L) and highest (H) RT. The average RT before calving (-20 to -2d) was 479 min/d (range 264 to 599), reached a minimum value at calving (30% of RT before calving), and was nearly stable after 15 DIM (on average 452 min/d). Milk yield in early lactation (on average 26.8 kg/d) was positively correlated with RT (r = 0.33). After calving, compared with H cows, the L cows had higher values of haptoglobin (0.61 and 0.34 g/L at 10 DIM in L and H, respectively) for a longer time, had a greater increase in total bilirubin (9.5 and 5.7 μmol/L at 5 DIM in L and H), had greater reductions of albumin (31.2 and 33.5 g/L at 10 DIM in L and H) and paraoxonase (54 and 76 U/ml at 10 DIM in L and H), and had a slower increase of total cholesterol (2.7 and 3.2 mmol/L at 20 DIM in L and H). Furthermore, a lower average value of liver functionality index was observed in L (-6.97) compared with H (-1.91) cows. These results suggest that severe inflammation around parturition is associated with a slower increase of RT after calving. Furthermore, more than 90% of the cows in the L group had clinical diseases in early lactation compared with 42% of the H cows. Overall, our results demonstrate the utility of monitoring RT around calving, and in particular during the first week of lactation, as a way to identify in a timely fashion those cows at a greater risk of developing a disease in early lactation.
Reconstruction of Cardiac Displacement Patterns on the Chest Wall by Laser Speckle Interferometry (1985)

Laser speckle interferometry has been used to determine the displacement pattern on the chest wall produced by the heart action during the systolic phase of the cardiac cycle. The time averaged specklegram, recorded in the image plane, is scanned by the pointwise method. From the values of the spacings of Young's fringes, measured at various points, the corresponding displacement pattern in the form of a 40 x 30 matrix, equal to that of the cardiac region, is reconstructed and color-coded by a PDP 11/23 image processor. This pattern shows significant variations in displacements at various locations. Depending on the clinical status of the subjects, further changes in the pattern are observed. The reconstructed cardiac displacement patterns, obtained by this new noncontact and noninvasive technique, provide information on the functioning of various parts of the heart in cardiac disorders which are in qualitative agreement with that of two-dimensional echocardiography.
Leveraging phase change memory to achieve efficient virtual machine execution (2013)

Virtualization technology is being widely adopted by servers and data centers in the cloud computing era to improve resource utilization and energy efficiency. Nevertheless, the heterogeneous memory demands from multiple virtual machines (VM) make it more challenging to design efficient memory systems. Even worse, mission critical VM management activities (e.g. checkpointing) could incur significant runtime overhead due to intensive IO operations. In this paper, we propose to leverage the adaptable and non-volatile features of the emerging phase change memory (PCM) to achieve efficient virtual machine execution. Towards this end, we exploit VM-aware PCM management mechanisms, which 1) smartly tune SLC/MLC page allocation within a single VM and across different VMs and 2) keep critical checkpointing pages in PCM to reduce I/O traffic. Experimental results show that our single VM design (IntraVM) improves performance by 10% and 20% compared to pure SLC- and MLC- based systems. Further incorporating VM-aware resource management schemes (IntraVM+InterVM) increases system performance by 15%. In addition, our design saves 46% of checkpoint/restore duration and reduces 50% of overall IO penalty to the system.
Extensions to the Path Computation Element Communication Protocol (PCEP) for Point-to-Multipoint Traffic Engineering Label Switched Paths (2010)

Point-to-point Multiprotocol Label Switching (MPLS) and Generalized MPLS (GMPLS) Traffic Engineering Label Switched Paths (TE LSPs) may be established using signaling techniques, but their paths may first need to be determined.The Path Computation Element (PCE) has been identified as an appropriate technology for the determination of the paths of point-to-multipoint (P2MP) TE LSPs.This document describes extensions to the PCE communication Protocol (PCEP) to handle requests and responses for the computation of paths for P2MP TE LSPs.
Modelling for Computer Controlled Neuromuscular Blockade (2005)

In this paper we present data collection and methods for the selection of a model class with the goal of automated neuromuscular blockade (NMB). Neuromuscular response was measured in the presence of rocuronium in rabbits (N=5) and humans (N=14). An average response was formed and used to determine optimal ARX and Laguerre representations for a wide range of orders and parameters. A 6th order Laguerre model was selected based on its accuracy and simplicity. Models were identified for each subject. For each group, variation was measured by comparison to the average response. The standard deviation of the average impulse response static gain was 45.4 and 45.8% of the mean for the rabbit and human models, respectively. The range of static gain was 121 and 159% of the mean for the rabbit and human datasets. Frequency domain analysis showed differences in gain of 12 and 15dB, and phase of 45 and 75° for the rabbit and human models respectively. With this knowledge, design and development of appropriate controllers for NMB will proceed.
Brain‐Derived Neurotrophic Factor Protects Dopamine Neurons Against 6‐Hydroxydopamine and <i>N</i>‐Methyl‐4‐Phenylpyridinium Ion Toxicity: Involvement of the Glutathione System (1992)

Brain-derived neurotrophic factor (BDNF) has recently been shown to enhance the survival of dopamine neurons in cultures derived from the embryonic rat mesencephalon. We now extend this study by demonstrating that, in addition to the effect of sustaining survival of dopaminergic neurons, BDNF also confers protection against the neurotoxic effects of 6-hydroxydopamine (6-OHDA) and N-methyl-4-phenylpyridinium ion (MPP+). Exposure of mesencephalic cultures to either 6-OHDA or MPP+ resulted in a loss of 70-80% of dopaminergic neurons, as determined by tyrosine hydroxylase (TH) immunocytochemistry. In BDNF-treated cultures, loss of TH-positive cells after exposure to either toxin was reduced to only 30%. To facilitate biochemical measurements, we studied SH-SY5Y dopaminergic neuroblastoma cells. BDNF was found to protect these cells from the dopaminergic neurotoxins, 6-OHDA and MPP+. Indicative of oxidative stress, treatment of SH-SY5Y cells with 10 microM 6-OHDA for 24 h caused a fivefold increase in the levels of oxidized glutathione (GSSG). Pretreatment with BDNF for 24 h completely prevented the rise in GSSG. Further examination revealed that BDNF increased the activity of the protective enzyme, glutathione reductase, by 100%. In contrast, BDNF had no effect on the activity of catalase. These results add further impetus to exploring the therapeutic potential of BDNF in animal models of Parkinson's disease.
Diphtheria Antitoxin Levels in US Blood and Plasma Donors (1996)

Plasma samples from 500 blood donors were titrated for diphtheria antitoxin (DAT) by the toxin neutralization (TN) test. Only 1.6% of donors had <0.01 IU/mL DAT, the minimum protective level against diphtheria; 15% had levels between 0.01 and <0.1 IU/mL, indicating basic protection, and 83.4% had levels > or =0.1 IU, indicating full protection. Three hundred fifty samples were studied by ELISA for diphtheria toxoid IgG antibodies to assess the utility of the assay as a quick, convenient method for evaluating diphtheria immunity. Although the correlation between TN and ELISA titers for the 350 samples was high (r = .80), there was no correlation (r = .07) for samples with antitoxin titers <0.1 IU/mL, the level of special interest for serosurveys for protection. Titration of 62 immune globulin samples (prepared from 1957 to 1994) showed that DAT levels in Massachusetts blood donors increased concurrently with increased use of tetanus-diphtheria vaccine in the state.
A model for the prostaglandin synthetase cyclooxygenation site and its inhibition by antiinflammatory arylacetic acids (1977)

Conformational analysis of indomethacin and other nonsteroidal antiinflammatory drugs leads to formulation of a hypothetical complementary receptor site model. The same model can serve to describe the prostaglandin cyclooxygenase active site, and, indeed, arachidonic and other polyunsaturated fatty acids could be folded on the model in a manner which rationalizes their stereospecific transformation to cyclic endo-peroxides (PGG). The model rationalizes the structure-activity relationships of enzyme substrates and inhibitors and appears to be in agreement with biochemical studies of the enzyme.
A Facile and Effective Screening Method for p21WAF1 Promoter Activators from Microbial Metabolites. (2001)

We have developed a novel p21WAF1 promoter activator screening system based on rapid and facile luciferase activity assay of a model cell system (H1299/tsp53-luc cells), a stable luciferase expression cell line established by transfecting H1299/tsp53 cells with a reporter gene construct pWWP-Luc-BSD. This plasmid was constructed by subcloning the 2.4 kb p21WAF1 promoter and a 2.6 kb of luciferase cDNA fragment activated by the p21WAF1 promoter into a pMAM2-BSD expression vector containing the blasticidin S deaminase gene (BSD). A BSD-resistant clone H1299/tsp53-luc#4, showing the highest response to p53 activation (by temperature shift from 37 degrees C to 32 degrees C) by luciferase production, was used for screening microbial culture broths. Among approximately 1200 screened samples, trichostatin A related compounds and a new compound, lucilactaene, were isolated. This provides an effective and facile screening system for p21WAF1 promoter activators which should be of considerable value in the rapid identification of new anticancer agents.
Base Removers and Strand Scissors: Different Strategies Employed in Base Excision and Strand Incision at Modified Base Residues in DNA (2000)

International audience
The Regulation of Food Intake by Peptidesa (1989)

Historically, nutrients and related metabolic signals were considered to control the onset and offset of meals. Recent research has focused upon the roles of peptides found in the gastrointestinal tract and brain as alternate controllers of these processes. During a meal, the gut secretes a variety of peptides as part of the digestive process. Some of these substances, acting as hormonal or as local signals, may also provide information which is relayed to the central nervous system, causing eating to stop and producing the sense of satiety. When administered to animals or people before a meal, exogenous cholecystokinin (CCK), the most studied of the putative satiety peptides, reduces food intake in a dose-dependent manner. Recent findings support the concept that endogenous CCK acts during meals to limit meal size, and evidence is reviewed suggesting a possible pathophysiological role for CCK in bulimia. Adiposity is also regulated via peptide hormones, especially insulin. Insulin is secreted in direct proportion to adiposity, and blood-borne insulin gains access to brain areas important in the regulation of feeding. The administration of insulin into the brain causes reduced eating and weight loss.
Slow Cycle Fatigue Creep Performance of Pb-Free (LF) Solders (2007)

Electronics industry is successfully transitioning into lead-free (LF) solders to comply with government regulations. There are many challenges associated with reliability life prediction for LF solders such as the selection of temperature cycle test methods, material compatibility issues, and reliability models. This paper focuses on investigating the effect of extended dwell time on LF reliability under thermal cycling for both flip chip BGA packages and sockets. Extensive experimental temperature cycle results for different pitch FC BGAs, and sockets have shown that LF (Sn-4.0Ag-0.5Cu) solder has a better fatigue performance than Sn/Pb over a wide range of extended dwell times. Long-dwell time temperature cycle results revealed that LF will not cross over Sn/Pb performance in the extended dwell time testing up to 8-hour cycle time for the temperature range between -25 and +100deg C. It is also noted that the margin in fatigue life between LF and Sn/Pb becomes smaller with the increased dwell time. This is consistent with the creep properties of LF solder. Finite element modeling results corroborated the experimental data. Detailed failure analysis for both socket and flip chip BGA units demonstrated that LF has much less crack propagation rate than Sn/Pb even with very long dwell time showing better fatigue performance compared to Sn/Pb.
Geometry-Guided 3D Data Interpolation for Projection-Based Dynamic Point Cloud Coding (2018)

With the recent improvements in acquisition techniques for 3D media applications, it has become easier to collect 3D data, for example, dynamic point cloud data. Such point clouds consist of a large amount of 3D coordinates, which describe a scene or object in 3D space by its geometry and texture attributes. Moreover, they are an effective representation of 3D environments for applications such as Augmented Reality or Virtual Reality. One of the main problems for such data is that the number of points is typically too large to allow for real-time transmission or efficient storage. Thus, compressing such 3D data is a key issue to reduce the amount of required bandwidth or memory. This paper presents a method for efficient compression of dynamic point cloud data within the current MPEG standardization framework for dynamic point cloud compression. The key benefit of the presented work is the reduced number of encoded and decoded 3D points compared to the reference framework, thus encoding and decoding complexity is reduced significantly. Objective results show a speed-up of around 35-40% in coding times. Furthermore, reconstruction quality is preserved, thus reducing bit rate requirements by up to 30%. Visual results verify the improved reconstruction quality, and compared to the reference at the same computational complexity, coding efficiency is improved by over 40%.
Coarse frame synchronisation for OFDM based wireless communication systems (2002)

This paper presents a method to fast and easily detect the beginning of a frame which is based on a special frame synchronisation symbol. The method is primarily useful for OFDM systems but can be applied for other systems as well. The implementation can be done with a low power analogue circuit which generates an event that is independent from the remaining signal processing, thus allowing one to switch of the unused circuitry. A digital solution is also given. It is shown that the method is sufficiently reliable for most wireless communication systems under consideration.
Kallikrein gene expression in the gonadotrophin-stimulated rat ovary (2001)

The kallikreins (KLKs) are a highly conserved multi-gene family of serine proteases that are expressed in a wide variety of tissues and act on a diverse range of substrates. KLK-like enzyme activity has variously been reported to increase or decrease during the period leading up to ovulation in the equine chorionic gonadotrophin (eCG)primed, human chorionic gonadotrophin (hCG)-stimulated immature rat ovary. These earlier studies, which used biochemical assays to detect enzyme activity, lacked the specificity and sensitivity necessary to characterise conclusively the activity of the individual KLK gene family members. In this study, we have used a gene-specific RT-PCR/Southern hybridisation strategy to delineate the expression patterns of six of the individual KLK genes expressed in the rat ovary (rKLK1-3 and rKLK7-9). We have identified three broad patterns of expression in the eCG/hCG-stimulated ovary in which there is either a post-eCG increase/pre-ovulatory decrease in rKLK expression (rKLK1, rKLK3), a peri-ovulatory decrease in expression (rKLK2, rKLK8) or a relatively unchanged pattern of expression (rKLK7, rKLK9). In addition to clarifying the earlier biochemical studies, these findings support a differential role for the individual KLKs in the ovulatory process.
Apitherapy: Usage and Experience in German Beekeepers (2007)

This study aimed to investigate the practice of apitherapy - using bee products such as honey, pollen, propolis, royal jelly and bee venom to prevent or treat illness and promote healing - among German beekeepers and to evaluate their experiences with these therapies. A questionnaire incorporating two instruments on beekeepers' physical and mental health and working practice was included in three German beekeeping journals and readers were asked to complete it. The instrument included questions on the use of apitherapy. Simple descriptive methods, bivariate correlation, cross-tabulation and one-way ANOVA were used to analyze the data. Altogether 1059 completed questionnaires were received. The beekeepers reported the most effective and favorable therapeutic effects with honey, followed by propolis, pollen and royal jelly. The factors associated with successful experiences were: age, number of hives tended, health consciousness, positive experiences with one product and self-administration of treatment. Beekeepers were asked for which condition they would employ propolis and pollen. They reported that they used propolis most frequently to treat colds, wounds and burns, sore throats, gum disorders and also as a general prophylactic, while pollen was most commonly used as a general prophylactic and, less frequently, in treating prostate diseases. No adverse experiences were reported. The potential benefit of bee products is supported by the positive experiences of a large group of beekeepers who use some of these products to treat a wide range of conditions. The indications and treatments given here may be important in selecting bee products and designing future trials.
Pulsed Hertzian dipole radiation and electrostatic discharge events in manufacturing (2013)

A destructive Charged Device Model electrostatic discharge event can happen in semiconductor manufacturing and should be detectable from radiation that results from collapse of an electric dipole. The analytically describable radiation field pulse of CDM can be readily produced with a new instrument that creates dipole collapse at will. A coaxial monopole E-field antenna's transfer function gives the antenna signal in near-field, and experiments compare well with theory. A major feature of the antenna response to this field pulse is a bipolar "monocycle" pulse. A transmission linebased synthetic monocycle pulser, for characterizing antenna-driven ESD detectors, can be built and is described.