gebhart/patrepeval huggingface dataset:
Early-Morning Dystonia (1979)

Four women with Parkinson's disease undergoing prolonged levodopa therapy had daily episodes of dystonic posturing, affecting one lower extremity, several years after initiation of treatment. The dystonia occurred only in the early morning, on awakening and before the first dose of levodopa, when the patients were in the akinetic-rigid state with no dyskinesias. It further interfered with gait, slowly subsided within one to two hours, and did not recur until next morning. This abnormal involuntary posture was unaffected by manipulations of daily levodopa dosage and schedule, completely disappeared after withdrawal of drug therapy, and recurred following its readministration. Additional adverse reactions including dyskinesias, "on-off" phenomena, and declining efficacy of levodopa were present in all patients. Early-morning dystonia may represent another late side effect secondary to long-term levodopa administration in parkinsonism.
Extended Grassmann Kernels for Subspace-Based Learning (2008)

Subspace-based learning problems involve data whose elements are linear sub-spaces of a vector space. To handle such data structures, Grassmann kernels have been proposed and used previously. In this paper, we analyze the relationship be-tween Grassmann kernels and probabilistic similarity measures. Firstly, we show that the KL distance in the limit yields the Projection kernel on the Grassmann manifold, whereas the Bhattacharyya kernel becomes trivial in the limit and is suboptimal for subspace-based problems. Secondly, based on our analysis of the KL distance, we propose extensions of the Projection kernel which can be ex-tended to the set of affine as well as scaled subspaces. We demonstrate the ad-vantages of these extended kernels for classification and recognition tasks with Support Vector Machines and Kernel Discriminant Analysis using synthetic and real image databases. 1
Multi-Path Forwarding Strategy for Named Data Networking Based on Pending Interests and Available Bandwidth (2021)

Named Data Networking (NDN) is a new Internet architecture, and it focuses on the content or name rather than the location or address. One-to-many communication has become the main feature of NDN networks. Therefore, forwarding strategy plays an important role in the content delivery performance enhancement of NDN networks. Most existing schemes tend to consider one or two metrics of different faces, such as round trip time(RTT), pending Interests (PI) and bandwidth (BW). Such single-metric or dual-metric designs usually lower accuracy in characterizing path performance. In addition, the Data packet can carry rich performance information of the path it passes through, which is more powerful than estimating the path performance on the local interface. To this end, we propose a multi-path forwarding strategy named PIBW, considering multiple metrics including PI, available BW, etc. We implement PIBW and conduct performance evaluations based on ndnSIM. Simulation evaluation shows that PIBW outperforms baseline solutions in terms of throughput, link bandwidth utilization and convergence time.
Rio: A System Solution for Sharing I/O between Mobile Systems (2013)

Mobile systems are equipped with a diverse collection of I/O devices, including cameras, microphones, sensors, and modems. There exist many novel use cases for allowing an application on one mobile system to utilize I/O devices from another. This paper presents Rio, an I/O sharing solution that supports unmodified applications and exposes all the functionality of an I/O device for sharing. Rio's design is common to many classes of I/O devices, thus significantly reducing the engineering effort to support new I/O devices. Our implementation of Rio on Android consists of 6700 total lines of code and supports four I/O classes with fewer than 450 class-specific lines of code. Rio also supports I/O sharing between mobile systems of different form factors, including smartphones and tablets. We show that Rio achieves performance close to that of local I/O for audio, sensors, and modems, but suffers noticeable performance degradation for camera due to network throughput limitations between the two systems, which is likely to be alleviated by emerging wireless standards.
Electrodeformation for single cell mechanical characterization (2011)

This paper presents the use of electrodeformation as a method for single cell mechanical characterization. Cells were placed between two microelectrodes with a rectangular AC electric field applied and cell deformation recorded. Numerical simulations were performed to model cell electrodeformation based on the Maxwell stress tensor formulation in which effects of cell electrical property variations on their electrodeformed behaviors were investigated. By comparing the measured morphological changes with those obtained from numerical simulations, we were able to quantify Young's modulus of SiHa cells (601±183 Pa) and ME180 cells (1463±649 Pa), which were then verified using conventional micropipette aspiration (SiHa: 400±290 Pa and ME180: 1070±580 Pa).
Dynamic resource management framework for wireless LAN (2005)

Distributed middleware technology is emerging as a flexible promising solution for network resource management and QoS (quality of service) control in a distributed environment. The concept of dynamic bandwidth reservation (DBR) algorithm additionally allocates the terminated bandwidth for an ongoing call is one of the promising methods to reduce the new call blocking and handoff call dropping probabilities. Dynamic resource management (DRM) framework concentrates on design and developing a framework for allocating shared resources to support multiple QoS and to provide probabilistic assurances of service in wireless networks. Existing methods and architecture do not guarantee on resource allocation and management in mobile, wireless and ad hoc networks. When a mobile node (MN) moves from its home network (HN) to foreign network (FN), the minimal required resources and services can be provided locally in the current network where it is connected presently. Dynamic resource management (DRM) framework provides an application level simulator for wireless network with new QoS management concept. DRM framework comprises of a set of programmable distributed objects and distributed middleware. DRM framework is constructed using distributed objects and distributed middleware. Distributed object carry applications across networks and allow them to connect to local server with FN in the same way as they had moved from the HN. The framework must dynamically accommodate multimedia calls with different bandwidth requirements in response to network traffic and it supports mobility management. The utility of DRM framework describes how the required resources are reserved based on the user priority option in an adaptive manner. The proposed DBR algorithm guarantees the required bandwidth during call setup and handoff without any flow rejection.
Identification of lutein and zeaxanthin oxidation products in human and monkey retinas. (1997)

Lutein, zeaxanthin, 3'-epilutein, and 3-hydroxy-beta,epsilon-caroten-3'-one in human retina may be interconverted through a series of oxidation-reduction reactions similar to our earlier proposed metabolic transformation of these compounds in humans. The presence of the direct oxidation product of lutein and 3'-epilutein (metabolite of lutein and zeaxanthin) in human retina suggests that lutein and zeaxanthin may act as antioxidants to protect the macula against short-wavelength visible light. The proposed oxidative-reductive pathways for lutein and zeaxanthin in human retina, may therefore play an important role in prevention of age-related macular degeneration and cataracts.
Breast patterns as an index of risk for developing breast cancer (1976)

The radiographic appearance of the breast parenchyma provides a method of predicting who will develop a breast cancer. This paper describes a restrospective study of 7,214 patients. On the basis of the radiographic appearance of the breast parenchyma, patients were placed into one of four groups of risk for developing carcinoma of the breast. Follow-up studies revealed a stepwise progression in the incidence of developing carcinoma of the breast at least 6 months after the radiographic examination. In one of the two substudies, there was a 37 times greater incidence for those at highest risk compared to the low risk group. The classifications presented are thought to be of value in the everyday practice of mammography as well as in planning screening programs.
Characterization of cross-spring pivots for micropositioning applications (2015)

Compliant mechanisms gain at least part of their mobility from the deflection of flexible member. They are characterised by high precision, possibility of monolithic manufacturing (‘design for no-assembly’) and of parallel kinematics, as well as no backlash and wear. Several analytical and numerical methods are used in this work to characterise the behaviour of compliant rotational mechanisms, known as cross-spring pivots, aimed at micropositioning applications. In a typical design configuration, a cross-spring pivot allows a movable block to rotate, via the deflection of leaf springs, with respect to the fixed block. In general, the pivot is loaded with a pure bending moment. When ultra-high precision is required, the limits of applicability of approximated calculation algorithms have to be determined. The results obtained by employing these methods are thus compared with results obtained via the generalized nonlinear Elastica-type approach, results obtained by using nonlinear finite element calculations as well as the experimental data reported in literature. The finite element model, tuned to the results of the exact Elastica approach, allows also to consider the influence of lateral loads and of non-symmetrical pivot configurations where the angle or point of intersection of the leaf springs, or even the initial curvature of the springs, can be varied. The aim of this part of the work is to determine the influence of the cited design parameters on the minimisation of the parasitic shift of the geometric centre of the pivot as well as on the minimisation of the variability of the rotational stiffness of the pivot so as to ensure its stability and avoid the possible occurrence of buckling. The obtained results allow therefore determining design solutions applicable in ultra-high precision micropositioning applications, e.g. in the field of production or of handling and assembly of MEMS.
Relationship between HbA1c and Continuous Glucose Monitoring in Chinese Population: A Multicenter Study (2013)

Our study provided the reference data of the relationship between HbA1c and CGM in Chinese subjects.
Hematologic Malignant Neoplasms After Drug Exposure in Rheumatoid Arthritis (2008)

In this large cohort of patients with rheumatoid arthritis, the greatest relative risk for hematologic malignant neoplasms was noted after use of cyclophosphamide. Assessments of risk related to newer and emerging therapies should carefully consider previous and concomitant medication exposures.
Confidentiality metrics and Smart Selective Encryption for HD H.264/AVC videos (2013)

International audience
Role of proteolysis in lenses: a review. (1989)

It has been suggested that proteases are involved in removal of damaged or obsolete proteins and/or that the activation of proteases could contribute to cataract formation. This review summarizes the properties of several recently studied lens endopeptidases including: trypsin-like protease, multicatalytic endopeptidase complex, membrane bound proteases, and calpain. Properties discussed include composition, substrate specificity, distribution, changes in activity during aging, and regulation. Additionally, properties of the lens ubiquitin conjugation system are reviewed. When possible, an attempt was made to relate these findings to whether the lens proteolytic activity was involved in clearing damaged proteins, or whether it could contribute to cataract formation. Clearing of damaged or obsolete lens proteins may involve the participation of several protease activities. Findings suggest that lens protease activities are lost at variable rates during aging, and differ in concentration between species. It was concluded that the consequence of proteolytic activity in the lens may depend closely on the compliment of proteolytic activities found. For instance, proteases causing only partial degradation of lens proteins may predominate in lenses undergoing cataract formation, while proteases assisting in the removal of partially degraded proteins are lost. The partially degraded lens proteins, as well as other denatured lens proteins, may then accumulate and lead to cataract formation.
Empirical Parameters of Solvent Polarity (2010)

This chapter contains sections titled: Linear Gibbs Energy Relationships Empirical Parameters of Solvent Polarity from Equilibrium Measurements Empirical Parameters of Solvent Polarity from Kinetic Measurements Empirical Parameters of Solvent Polarity from Spectroscopic Measurements Empirical Parameters of Solvent Polarity from Other Measurements Interrelation and Application of Solvent Polarity Parameters Multiparameter Approaches
SoftSMPL: Data‐driven Modeling of Nonlinear Soft‐tissue Dynamics for Parametric Humans (2020)

Abstract We present SoftSMPL, a learning‐based method to model realistic soft‐tissue dynamics as a function of body shape and motion. Datasets to learn such task are scarce and expensive to generate, which makes training models prone to overfitting. At the core of our method there are three key contributions that enable us to model highly realistic dynamics and better generalization capabilities than state‐of‐the‐art methods, while training on the same data. First, a novel motion descriptor that disentangles the standard pose representation by removing subject‐specific features; second, a neural‐network‐based recurrent regressor that generalizes to unseen shapes and motions; and third, a highly efficient nonlinear deformation subspace capable of representing soft‐tissue deformations of arbitrary shapes. We demonstrate qualitative and quantitative improvements over existing methods and, additionally, we show the robustness of our method on a variety of motion capture databases.
Overview of the IEEE 802.15.4 standards family for Low Rate Wireless Personal Area Networks (2010)

Low Rate Wireless Personal Area Networks (LR-PAN) such as sensor networks have become very popular in recent years. These networks can be implemented with little or no infrastructure. The first step of standardization for such LR networks was taken in 2003 when the IEEE 802.15.4 was approved. This standard however went through an enhancement process and a newer version was released in 2006 known as the IEEE 802.15.4-2006 (or 802.15.4b) standard. However neither of the two standards supported ranging capabilities between nodes in the network. In order to support distance and hence location information, the IEEE 802.15.4-2007 was approved (also known as 802.15.4a). Standardization process continued and newer standards such as the IEEE 802.15.4c and 4d were sanctioned very recently. This paper reviews the network topologies, physical and MAC layers of the IEEE 802.15.4 family.
GPS based track and trace for transparent and sustainable global supply chains (2011)

This paper provides an approach to use a continuous track and trace system based on GPS (Global Positioning System) technology in production networks. Therefore the ild institute for logistics and service management (FOM Essen, Germany) operates a new GPS based track and trace system with the name GPS. LAB. The results of the first trials with the existing system in the context of production planning and supply chain event management are presented in this paper. In a special example the GPS track and trace system is used to identify delays in an inbound logistics process of a groupage freight depot to show the influence of the delay on the routing of last-mile transports. This could be labelled as a last mile event routing (LMER) concept.
ENaC and Its Regulatory Proteins as Drug Targets for Blood Pressure Control (2008)

Hypertension is a serious medical problem affecting millions of people worldwide. A key protein regulating blood pressure is the Epithelial Na(+) Channel (ENaC). In accord, loss of function mutations in ENaC (PHA1) cause hypotension, whereas gain of function mutations (Liddle syndrome) result in hypertension. The region mutated in Liddle syndrome, called the PY motif (L/PPxY), serves as a binding site for the ubiquitin ligase Nedd4-2, a C2-WW-Hect E3 ubiquitin ligase. Nedd4-2 binds the ENaC-PY motif via it WW domains, ubiquitylates the channel and targets it for endocytosis, a process impaired in Liddle syndrome due to poor binding of the channel to Nedd4-2. This leads to accumulation of active channels at the cell surface and increased Na(+) (and fluid) absorption in the distal nephron, resulting in elevated blood volume and blood pressure. Compounds that destabilize cell surface ENaC, or enhance Nedd4-2 activity in the kidney, could potentially serve as drug targets for hypertension. In addition, recent discoveries of regulation of activation of ENaC by proteases such as furin, prostasin and elastase, which cleave the extracellular domain of this channel leading to it activation, as well as the identification of inhibitors that block the activity of these proteases, provide further avenues for drug targeting of ENaC and the control of blood pressure.
Survey of the genetic information carried in the genome of Eucalyptus camaldulensis (2011)

The genetic information in the genome of Eucalyptus camaldulensis was investigated by sequencing the genome and the cDNA using a combination of the conventional Sanger method and next-generation sequencing methods, followed by intensive bioinformatics analyses. The total length of the non-redundant genomic sequences thus obtained was 654,922,307 bp consisting of 81,246 scaffolds and 121,194 singlets. These sequences accounted for approximately 92% of the gene-containing regions with an average G+C content of 33.6%. A total of 77,121 complete and partial structures of protein-encoding genes have been deduced. Comparison of the genes mapped on the KEGG pathways or located in the KOG classification with those in other plant species revealed the characteristics of the E. camaldulensis genome, and it was found that 23 pathways contained enzymes present only in the E. camaldulensis genome. Polymorphism analysis using microsatellite markers developed from the genomic sequence data obtained was performed with six Eucalyptus species collected from various parts of the world to estimate their genetic diversity, and the usefulness of these markers was demonstrated. The genomic sequence and accompanying information presented here are expected to serve as valuable resources for the acceleration of fundamental and applied research with Eucalyptus, especially in the fields of paper production and industrial materials. Further information on the genomic and cDNA sequences and microsatellite markers is available at http://www.kazusa.or.jp/eucaly/.
Cellular Hypertrophy and Calcification of Embryonal Carcinoma-Derived Chondrogenic Cell Line ATDC5 In Vitro (1997)

During the process of endochondral bone formation, proliferating chondrocytes give rise to hypertrophic cells, which then deposit a mineralized matrix to form calcified cartilage prior to replacement by bone. Previously, we reported that a clonal cell line, ATDC5, undergoes efficient chondrogenic differentiation through a cellular condensation stage. Here we report that the differentiated ATDC5 cells became hypertrophic at the center of cartilage nodules, when the cells ceased to grow. Formation of hypertrophic chondrocytes took place in association with type X collagen gene expression and a dramatic elevation of alkaline phosphate (ALPase) activity. After 5 weeks of culture, mineralization of the culture could be discerned as Alizarin red-positive spots, which spread throughout the nodules even in the absence of beta-glycerophosphate. Electron microscopy and electron probe microanalysis revealed that calcification was first initiated at matrix vesicles in the territorial matrix and that it advanced progressively along the collagen fibers in a manner similar to that which occurs in vivo. The infrared spectrum of the mineralized nodules indicated two absorption doublets around 1030 cm-1 and 600 cm-1, which are characteristic of apatitic mineral. Calcifying cultures of ATDC5 cells retained responsiveness to parathyroid hormone (PTH): PTH markedly inhibited elevation of ALPase activity and calcification in the culture in a dose-dependent manner. Thus, we demonstrated that ATDC5 cells keep track of the multistep differentiation process encompassing the stages from mesenchymal condensation to calcification in vitro. ATDC5 cells provide an excellent model to study the molecular mechanism underlying regulation of cartilage differentiation during endochondral bone formation.
Extensions of the Leuckart Synthesis of Amines (1936)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExtensions of the Leuckart Synthesis of AminesA. W. Ingersoll, J. H. Brown, C. K. Kim, W. D. Beauchamp, and Garland JenningsCite this: J. Am. Chem. Soc. 1936, 58, 9, 1808–1811Publication Date (Print):September 1, 1936Publication History Published online1 May 2002Published inissue 1 September 1936https://pubs.acs.org/doi/10.1021/ja01300a089https://doi.org/10.1021/ja01300a089research-articleACS PublicationsRequest reuse permissionsArticle Views689Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts