gebhart/patrepeval huggingface dataset:
CLIP: Continuous Location Integrity and Provenance for Mobile Phones (2015)

Many location-based services require a mobile user to continuously prove his location. In absence of a secure mechanism, malicious users may lie about their locations to get these services. Mobility trace, a sequence of past mobility points, provides evidence for the user's locations. In this paper, we propose a Continuous Location Integrity and Provenance (CLIP) Scheme to provide authentication for mobility trace, and protect users' privacy. CLIP uses low-power inertial accelerometer sensor with a light-weight entropy-based commitment mechanism and is able to authenticate the user's mobility trace without any cost of trusted hardware. CLIP maintains the user's privacy, allowing the user to submit a portion of his mobility trace with which the commitment can be also verified. Wireless Access Points (APs) or colocated mobile devices are used to generate the location proofs. We also propose a light-weight spatial-temporal trust model to detect fake location proofs from collusion attacks. The prototype implementation on Android demonstrates that CLIP requires low computational and storage resources. Our extensive simulations show that the spatial-temporal trust model can achieve high (> 0.9) detection accuracy against collusion attacks.
Review of the Career of Professor Dr. Herbert Remmer (2004)

This article is a laudatio summarizing the scientific career and accomplishments of Herbert Remmer as observed by one of his first students. The article traces over fifty years of multiple contributions of Herbert Remmer to pharmacology and toxicology and clearly identifies the leadership characteristics of this memorable man.
REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF BUSPIRONE HYDROCHLORIDE (II) : Oral Administration to Rats During Perinatal and Lactation Periods (1990)

Buspirone hydrochloride (buspirone), an anxiolytic drug, was administered orally to pregnant Crj: CD (Sprague-Dawley) rats from day 17 of gestation through day 20 of postpartum at dose levels of 2, 12 and 75 mg/kg/day. The summarized results obtained are as follows: 1. Decreased activity was observed for F0 dams at buspirone 75 mg/kg. Further, the suppression of maternal body weight gains accompanied by the reduction of food consumption was shown during the administration period at buspirone 12 mg/kg and higher. 2. Brain and adrenal weights were increased in F0 dams at buspirone 12 mg/kg and higher. Besides, lung and pituitary weights were augmented in F0 dams at buspirone 75 mg/kg. 3. Buspirone 75 mg/kg brought the increased number of stillbirths in F1 neonates. 4. Buspirone 75 mg/kg lowered the viability of newborns (F1) on postnatal day 3 and prolonged the days required for pinnae detachment, presence of abdominal hair and eye opening in offspring (F1), but failed to function their learning ability, motility, motor activity or emotional development. 5. Body weight gains were depressed in both male and female F1 rats at buspirone 12 mg/kg and higher. Food consumption was also decreased in both sexes at the same dose levels. 6. Heart weights were decreased in female F1 rats after mating at buspirone 12 mg/kg and higher. Further, buspirone 75 mg/kg brought a suppression of brain weights at 10 weeks of age in male and female F1 rats, but failed to affect their reproductive ability. 7. F2 neonates derived from F1 rats whose dams had ever received buspirone during the perinatal and lactation periods showed no changes in observation items at birth. Based on these results, the no-effect dose level of oral buspirone under the present experimental condition was estimated to be 2 mg/kg/day against dams and their offspring.
Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery (2008)

Chronic lung ischemia induces over-expression of pro-apoptotic factors. Lung reperfusion is followed by a dramatic transient increase in EC death that may explain the development of endothelial dysfunction after PE. Anti-apoptotic agents may hold considerable potential for preventing postoperative complications.
Integrated Lateral Flow Device for Flow Control with Blood Separation and Biosensing (2017)

Lateral flow devices are versatile and serve a wide variety of purposes, including medical, agricultural, environmental, and military applications. Yet, the most promising opportunities of these devices for diagnosis might reside in point-of-care (POC) applications. Disposable paper-based lateral flow strips have been of particular interest, because they utilize low-cost materials and do not require expensive fabrication instruments. However, there are constraints on tuning flow rates and immunoassays functionalization in papers, as well as technical challenges in sensors' integration and concentration units for low-abundant molecular detection. In the present work, we demonstrated an integrated lateral flow device that applied the capillary forces with functionalized polymer-based microfluidics as a strategy to realize a portable, simplified, and self-powered lateral flow device (LFD). The polydimethylsiloxane (PDMS) surface was rendered hydrophilic via functionalization with different concentrations of Pluronic F127. Controlled flow is a key variable for immunoassay-based applications for providing enough time for protein binding to antibodies. The flow rate of the integrated LFD was regulated by the combination of multiple factors, including Pluronic F127 functionalized surface properties and surface treatments of microchannels, resistance of the integrated flow resistor, the dimensions of the microstructures and the spacing between them in the capillary pump, the contact angles, and viscosity of the fluids. Various plasma flow rates were regulated and achieved in the whole device. The LFD combined the ability to separate high quality plasma from human whole blood by using a highly asymmetric plasma separation membrane, and created controlled and steady fluid flow using capillary forces produced by the interfacial tensions. Biomarker immunoglobulin G (IgG) detection from plasma was demonstrated with a graphene nanoelectronic sensor integrated with the LFD. The developed LFD can be used as a flexible and versatile platform, and has the potential for detecting circulating biomarkers from whole blood. Sandwich-immunoassays can be performed directly on the LFD by patterning receptors for analytes on a desired substrate, and detections can be performed using a variety of sensing methods including nanoelectronic, colorimetric, or fluorescence sensors. The described bio-sensing technology presents an alternative for POC testing using small samples of human whole blood. It could benefit regions with limited access to healthcare, where delays in diagnosis can lead to quick deterioration of the quality of life and increase the morbidity and mortality.
Calcineurin-inhibition Results in Upregulation of Local Renin and Subsequent Vascular Endothelial Growth Factor Production in Renal Collecting Ducts (2015)

Calcineurin inhibitors induce production of renin in the CD that may contribute to decreased renal blood flow. In turn, CD responds with increased VEGF production, resulting in disproportional vessel growth, further worsening the local hypoxia and striped fibrosis surrounding the CDs. Aliskiren, a direct renin inhibitor blocks these effects and improves CNI-induced nephropathy by decreasing renin production in the CDs. Our data suggest that Aliskiren may be used for the prevention of CNI nephrotoxicity.
Bandwidth–length trade-off figures of merit for electro-optic traveling wave modulators (2013)

Closed-form expressions explicitly relating modulation bandwidth and active length in electro-optic traveling wave modulators are presented which fully account for skin-effect electrode loss and optical-electrical wave velocities mismatch. Four operative margins have been identified where the bandwidth-length trade-off figure of merit takes simple forms.
Comparative Safety and Efficacy of Auranofin and Parenteral Gold Compounds: A Review (1983)

The comparative safety and efficacy of the orally active gold compound, auranofin, and parenteral gold compounds, principally gold sodium thiomalate, are reviewed. No difference in efficacy was detected in eight of the 12 published studies which compared auranofin and gold sodium thiomalate. Two studies favoured auranofin and two gold sodium thiomalate. Other parenteral gold compounds appeared more effective than auranofin. Adverse reactions and withdrawal rate from parenteral gold was found to be 2-3 times greater than from auranofin. Withdrawals due to inefficacy were found to be higher for auranofin than for parenteral gold although the incidence of inefficacy in the parenteral gold treated population was lower than that reported in other series. The nature of side effects from the two treatments was noticeably different; lower bowel symptoms with auranofin, and mucocutaneous lesions with parenteral gold compounds. Significant laboratory index changes were uncommon with both treatments, proteinuria being the most usual reason for withdrawal. Again the incidence of proteinuria and other laboratory abnormalities was less in the parenteral gold group than previously reported. Auranofin is possibly as effective and is definitely safer than parenteral gold compounds, and allows for longer periods of treatment.
Catalytic Asymmetric Conjugate Addition of Nitroalkanes to Cycloalkenones (2000)

Nitroalkanes add to cyclic and acyclic enones in an enantioselective manner in the presence of catalytic quantities of L-proline and trans-2,5-dimethylpiperazine as excess additive.
Beitrag zur automatisierten Steuerkennfeld-Applikation bei Fahrzeug-Dieselmotoren (2008)

In dieser Arbeit wurden die Schwerpunkte auf die automatisierte Basis-Applikation mit finaler Online-Bedatung gelegt. Die Bestimmung stabiler Grundkennfelder stellt die Hauptaufgabe in der ersten Phase der Steuergeräteapplikation dar und legt den Grundstein für die nachfolgende Feinapplikation. Die Untersuchungen wurden an einem 4-Zylinder-DI-Dieselmotor mit Common-Rail-Einspritzsystem durchgeführt. Den Ausgangspunkt des Applikationsansatzes bildet die Postulierung eines minimalen Versuchsaufwands nach dem Prinzip der globalen Wissenserhebung. Basierend auf diesen Überlegungen wurde ein Verfahren zur globalen Versuchsplanung entwickelt, das die Abdeckung des gesamten Motorhyperraumes durch die optimierte Verteilung der Designpunkte vorsieht. Die analytische Bewertung des Kandidatensatzes erfolgt anhand eines integralen Gütekriteriums. Hierbei dient das Takagi-Sugeno-Inferenz-System als globale Modellstruktur, das sich im Hinblick auf die Abbildung der mehrdimensionalen Motorzusammenhänge als besonders geeignet erwiesen hat. Des Weiteren wurde ein an den Versuchsplan angepasstes, automatisches Vermessungskonzept entwickelt, das Screening-Versuche zur Skizzierung der äußeren Parametergrenzen beinhaltet und die automatische, globale Vermessung der geplanten Designpunkte unter Adaption lokaler Versuchsraumbeschränkungen ermöglicht. Das automatische Vermessungsprinzip stellt einen notwendigen Beitrag zum durchgängigen und effizienten Entwicklungsprozess dar. Die Durchführung der modellbasierten Offline-Optimierungsmethodik hat gezeigt, dass nicht in erster Linie die Güte des globalen Motormodells, sondern vielmehr die fehlende Detail-Kenntnis über die Grenzen der Hyperräume ausschlaggebend für die Optimierungsqualität ist. Hierzu wurden verschiedene Modelltypen (Feedforward-Mehrschichtnetz, Radiale-Basisfunktionen-Netz, Sugeno-Inferenz-System, Polynom 3. Ordnung mit Wechselwirkungen) angewendet. Die Optimierungsqualität kann durch die Umsetzung der Online-Optimierung aufgrund der iterativen Verifikation der Lösungsvorschläge verbessert werden. Mit Hilfe der Fuzzy-Technik wurde ein Verfahren zur automatisierten Wissensbildung entwickelt, um aus gelernten Motorprozesszusammenhängen Lösungsvorschläge in Form von WENN-DANN-Regeln zu formulieren. Stationäre Motorbetriebspunktoptimierungen wurden mittels der modellierten, regelbasierten Wissensbasis in Verbindung mit einem heuristischen Steueralgorithmus online am Motorprüfstand verwirklicht. Die Ergebnisse bestätigen die Wirksamkeit des Online-Verfahrens in der vergleichenden Gegenüberstellung mit der modellbasierten Offline-Methode.
Effect of Kinesio Taping on bioelectrical activity of vastus medialis muscle. Preliminary report. (2008)

1. Clinically significant effects of Kinesio Taping in this study included an increase in the bioelectrical activity of the muscle after 24 hours of kinesio taping and the maintenance of this effect for another 48 hours following removal of the tape. 2. The decrease in muscle tone to the baseline value, which was observed during the fourth day of Kinesio Taping use, may have resulted from the time of effective use of the KT tape being shorter than previously believed and may restrict Kinesio Taping use. 3. Kinesio Taping used shortly before the motor activity it is supposed to support may fail to fulfil its function.
Introduction to Rocket Science and Engineering (2009)

An overall view of the vast spectrum of knowledge needed by practicing rocket scientists and engineers, Introduction to Rocket Science and Engineering presents the history and basics of rocket theory, design, experimentation, testing, and applications. It covers an array of fields, from advanced mathematics, chemistry, and physics to logistics, sys
Zn<sup>2+</sup>ion of the snake venom metalloproteinase (SVMP) plays a critical role in ligand binding: a molecular dynamics simulation study (2015)

Snake venom metalloproteinase (SVMP) is one of the major components of snake venom and it is a root causative agent for edema, local tissue damage, inflammation, blood coagulation and hemorrhage during the snake bite.
α‐Methylacyl‐CoA racemase – an ‘obscure’ metabolic enzyme takes centre stage (2008)

Branched-chain lipids are important components of the human diet and are used as drug molecules, e.g. ibuprofen. Owing to the presence of methyl groups on their carbon chains, they cannot be metabolized in mitochondria, and instead are processed and degraded in peroxisomes. Several different oxidative degradation pathways for these lipids are known, including alpha-oxidation, beta-oxidation, and omega-oxidation. Dietary branched-chain lipids (especially phytanic acid) have attracted much attention in recent years, due to their link with prostate, breast, colon and other cancers as well as their role in neurological disease. A central role in all the metabolic pathways is played by alpha-methylacyl-CoA racemase (AMACR), which regulates metabolism of these lipids and drugs. AMACR catalyses the chiral inversion of a diverse number of 2-methyl acids (as their CoA esters), and regulates the entry of branched-chain lipids into the peroxisomal and mitochondrial beta-oxidation pathways. This review brings together advances in the different disciplines, and considers new research in both the metabolism of branched-chain lipids and their role in cancer, with particular emphasis on the crucial role played by AMACR. These recent advances enable new preventative and treatment strategies for cancer.
Application of boron isotopes to the understanding of fluid–rock interactions in a hydrothermally stimulated oil reservoir in the Alberta Basin, Canada (2001)

Abstract Boron isotope ratios of reservoir minerals and fluids can be a useful geothermometer and monitor of fluid–rock interactions. In Cold Lake oil sands of northern Alberta, there is a large variation in δ 11 B of the produced waters generated during steam injection and recovery of oil and water. The higher temperature waters (∼ 200 °C) have isotopically light δ 11 B values (+ 3‰ to + 14‰) and high B contents (∼150 p.p.m.). It is inferred that the range of δ 11 B values of the hydrothermal fluids results from reaction with the reservoir rock, and is a function of the temperature of the fluid–rock interaction. The distinct B geochemistry of the produced waters can be used to show that there is no detectable mixing of the oil recovery waters with the regional formation waters or shallow groundwater aquifers containing potable water. Examination of B isotope ratios of reservoir minerals, before and after steam injection, allows the evaluation of sources of B in the reservoir. The only significant phase containing B is pumice. It shows generally positive δ 11 B values before steam injection and negative values after steam, with δ 11 B as low as − 28‰. Other possibly reactive phases include clay minerals and organic matter, but their abundance is not great enough to impact on the isotopic composition of the produced waters. This information makes it possible to evaluate the boron isotope fractionation equation derived from experimental data ( Williams LB (2000) Boron isotope geochemistry during burial diagenesis. PhD Dissertation. The University of Calgary, Alberta, Canada; Williams LB, Hervig RL, Holloway JR, Hutcheon I (2001a) Boron isotope geochemistry during diagenesis: Part 1. Experimental determination of fractionation during illitization of smectite. Geochimica et Cosmochimica Acta , in press). The results show that the fractionation curve predicts the difference between δ 11 B of the pumice and hydrothermal fluids in the Cold Lake reservoir. This not only indicates that the reservoir fluids have approached boron isotope equilibrium with the reservoir rock, but also shows that B isotopes provide a useful geothermometer for hydrothermally stimulated oil reservoirs.
Imaging heterogeneity of membrane and storage lipids in transgenic <i><scp>C</scp>amelina sativa</i> seeds with altered fatty acid profiles (2013)

Engineering compositional changes in oilseeds is typically accomplished by introducing new enzymatic step(s) and/or by blocking or enhancing an existing enzymatic step(s) in a seed-specific manner. However, in practice, the amounts of lipid species that accumulate in seeds are often different from what one would predict from enzyme expression levels, and these incongruences may be rooted in an incomplete understanding of the regulation of seed lipid metabolism at the cellular/tissue level. Here we show by mass spectrometry imaging approaches that triacylglycerols and their phospholipid precursors are distributed differently within cotyledons and the hypocotyl/radicle axis in embryos of the oilseed crop Camelina sativa, indicating tissue-specific heterogeneity in triacylglycerol metabolism. Phosphatidylcholines and triacylglycerols enriched in linoleic acid (C18:2) were preferentially localized to the axis tissues, whereas lipid classes enriched in gadoleic acid (C20:1) were preferentially localized to the cotyledons. Manipulation of seed lipid compositions by heterologous over-expression of an acyl-acyl carrier protein thioesterase, or by suppression of fatty acid desaturases and elongases, resulted in new overall seed storage lipid compositions with altered patterns of distribution of phospholipid and triacylglycerol in transgenic embryos. Our results reveal previously unknown differences in acyl lipid distribution in Camelina embryos, and suggest that this spatial heterogeneity may or may not be able to be changed effectively in transgenic seeds depending upon the targeted enzyme(s)/pathway(s). Further, these studies point to the importance of resolving the location of metabolites in addition to their quantities within plant tissues.
EFFECT OF LEVEL OF HAY INTAKE, METHOD OF MARKER ADMINISTRATION AND STAGE OF LACTATION ON RATE OF PASSAGE THROUGH THE RETICULORUMEN (1984)

Level of hay intake did not affect fractional outflow rate of chromium-mordanted particles from the reticulorumen in lactating dairy cows fed three levels of hay and a fixed level of concentrate. Outflow rate of a rumen liquid phase marker was significantly affected by level of hay intake. Key words: Cattle, level of feeding, rate of passage
Sequence variation of human endogenous retrovirus ERV9-related elements in an env region corresponding to an immunosuppressive peptide: transcription in normal and neoplastic cells (1993)

Evolutionarily conserved sequences corresponding to an immunosuppressive region in retroviral transmembrane proteins were amplified by the polymerase chain reaction from human genomic DNA and reverse-transcribed RNA from one glioma, three pieces of macroscopically normal brain tissue, kidney, lymphocytes, cultured embryonic lung cells, and a rhabdomyosarcoma cell line. Amplification products (125 bp) from DNA and RNA from the glioma and RNA from one normal piece of brain tissue were cloned and sequenced (45 clones). A variety of sequences similar to ERV9 (75 to 93%) were identified. Amplification products were immobilized on nylon filters and hybridized to four different synthetic oligonucleotides derived from the sequenced clones. Sequences without the stop codon seen in ERV9 in this region, possibly encoding functional immunosuppressive proteins, were present in RNA amplificates from all samples. The various cell types showed different hybridization patterns with the four probes. The open reading frame sequences were identified in genomic Southern blots, one probe detecting about 10 copies and another detecting a single copy. Northern (RNA) blots of mRNA from various normal human tissues revealed 2.5-kb (e.g., lung) and 10-kb (e.g., placenta) transcripts hybridizing to one of the probes.
Synthesis and characterization of potentially biodegradable thermotropic polyesters based on <i>p</i>‐hydroxybenzoic acid and glycolic acid (1994)

Abstract The synthesis of novel thermotropic liquid crystalline copolyesters derived from aliphatic hydroxy acid (glycolic acid, GA) and aromatic hydroxy acid ( p ‐hydroxybenzoic acid, PHBA) via a melt‐copolycondensation process in the presence of various catalysts was explored. The following three possible routes were checked: PHBA and GA in different feed ratios with or without a catalyst; PHBA and GA in different feed ratios with or without a catalyst in the presence of acetic anhydride as a condensation agent; and different PHBA derivatives were used to examine the reactivity of aromatic hydroxy acid. The copolycondensability, chemical structure, liquid crystallinity, textures and morphology, phase transition behaviors and thermal stability, and solubility were investigated by FTIR, NMR, DSC, TGA, and polarized‐light microscope. It has been found that only the 60–70 mol % PHBA‐containing copolyesters could exhibit a nematic liquid crystallinity. The as‐prepared polymers were brittle due to relatively lower molecular weights. © 1994 John Wiley & Sons, Inc.
Inclinations of the Facial Profile (1985)

The average inclinations of five basic facial profile lines and five individual facial profile segments were determined by direct anthropometry in a total group of 232 healthy young adults, all North American Caucasians. Significant sex-related differences were found only in the inclination of the forehead, the lower face, and the lower third of the face, with greater inclinations in males. These results were compared with data obtained from 49 art works produced by ancient, Renaissance, post-Renaissance, and contemporary artists and drawings of the face in scientific papers published by anthropologists, orthodontists, anatomists, and plastic surgeons. In the population study the average inclination of the general and the aesthetic profile lines, the lower face, the forehead, and the lower lip show a receding trend. The upper face is slightly protruded in the males and close to vertical in the females. The chin and the nose are equally prominent in both sexes. The only significant difference is in the greater recession of the lower face in males. The average female population values are reminiscent of those of the Renaissance. The average male inclinations come closest to the findings in the statues of antiquity. The population sample and the contemporary artists showed similar inclinations of the nasal bridge and the lower lip. Generally, the average inclination of the chin in the population is smaller than in any artistic style.