gebhart/patrepeval huggingface dataset:
The reliability and reproducibility of cephalometric measurements: a comparison of conventional and digital methods (2011)

In general, both methods of conventional and digital cephalometric analysis are highly reliable. Although the reproducibility of the two methods showed some statistically significant differences, most differences were not clinically significant.
Practical formal verification in microprocessor design (2001)

Practical application of formal methods requires more than advanced technology and tools; it requires an appropriate methodology. A verification methodology for data-path-dominated hardware combines model checking and theorem proving in a customizable framework. This methodology has been effective in large-scale industrial trials, including verification of an IEEE-compliant floating-point adder.
Validation of the GSM radio interface signalling protocols-selected studies (2002)

Selected results of the validation of the GSM (Groupe Special Mobile) radio interface signaling protocol are presented. During this process, specification errors have been detected and corrected. The simulations also contribute to the optimization of the signaling protocols. Points of interest are the random access procedures on common control channels, transitions among the various types of signaling channels, the signaling delay of signaling procedures due to varying transmission conditions and traffic flow. Selected aspects of overload control are studied. Experience showed that simulation is a very valuable supplement for the specification process.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A new Ge-68/Ga-68 generator system using a higher sorption capacity resin as adsorbent for Ge-68 (2009)

Our results demonstrate the potential applicability of the eNose as a non-invasive clinical tool to longitudinally monitor pulmonary SA infection status in children with CF.
Continuous Descent Approaches with Variable Flight-Path Angles under Time Constraints (2011)

In order to reduce noise nuisance around Schiphol Airport, a Continuous Descent Approach procedure was introduced in the late ’90s. Unfortunately, because unpredictable individual aircraft behavior lead to increased landing intervals for this procedure, it is currently only applied during night time operations. Time-of-Arrival control in the terminal area could reduce the landing interval for this procedure. The research presented in this paper investigates the influence of multiple segments with different flight-path angles on the time of arrival. A new procedure with Variable Flight-path angle (VFA) involving active planning of the approach from the pilot through a pilot support interface, presented in the Vertical Situation Display. A preliminary pilot-in-the-loop evaluation was conducted, to investigate pilot performance, workload and interface usability. Three scenarios were tested, all with different Required Time of Arrival. Workload was low for all scenarios and performance good for the two scenarios with early arrival times. For the scenario with a late arrival time, performance was mediocre. Changes in representation of the flap and gear cues and the addition of Estimated Time of Arrival information might improve the performance.
Drug-induced DNA hypermethylation and drug resistance in human tumors. (1989)

Drug-induced DNA hypermethylation was observed to constitute one component of the response of human tumor cells to toxic concentrations of commonly used cancer chemotherapy agents. In both human lung adenocarcinoma cells (HTB-54) and human rhabdomyosarcoma cells (CCl-136), pulse exposures to the topoisomerase II inhibitors etoposide and nalidixic acid; to the antibiotic doxorubicin; to the microtubule inhibitors vincristine, vinblastine, and colchicine; to the DNA cross-linking agent cisplatinum; to hydroxyurea; and to the antimetabolites 1-beta-D-arabinofuranosylcytosine, 5-fluorouracil, 5-fluorodeoxyuridine, and methotrexate were associated with profound drug-induced DNA hypermethylation. Exposure of human T-lymphocytes (MOLT-4) to toxic pulse doses of 3'-azidodideoxythymidine was associated with similar drug-induced DNA hypermethylation. In every case, drug-induced DNA hypermethylation was observed only when the degree of DNA synthesis inhibition caused by the drug exceeded 90% and when drug levels or duration of exposure was sufficient to kill 90-100% of exposed cells. Drug-induced DNA hypermethylation was shown not to represent a tissue culture phenomenon, since it occurred in vivo during high-dose 1-beta-D-arabinofuranosylcytosine and hydroxyurea treatments in two leukemic patients. Drug-induced alterations in DNA methylation were frequently biphasic, with hypomethylation occurring at drug concentrations which produced mild DNA synthesis inhibition and which killed less than 50% of exposed cells. Exposure to the alkylating agents 1,3-bis(2-chloroethyl)-1-nitrosourea and cyclophosphamide and to the antimetabolites 5-azadeoxycytidine and 6-thioguanine was associated with DNA hypomethylation at all studied concentrations in HTB-54 cells. Drug-induced DNA hypermethylation could be blocked by preexposure to hypomethylating agents administered at nontoxic to mildly toxic concentrations. Drug-induced DNA hypermethylation may be capable of creating drug-resistant phenotypes by inactivating genes the products of which are required for drug cytotoxicity. Perhaps paradoxically, drug-induced DNA hypermethylation may also produce a second class of drug-resistant tumor cells, characterized by overexpression of particular gene products, by potentiating the process of gene amplification.
Structural and biochemical basis for the difference in the helicase activity of two different constructs of SARS-CoV helicase. (2012)

The non—structural protein 13 (nsp13) of Severe Acute Respiratory Syndrome Coronavirus (SARS—CoV) is a helicase that separates double—stranded RNA or DNA with a 5'—3' polarity, using the energy of nucleotide hydrolysis. We have previously determined the minimal mechanism of helicase function by nsp13 where we demonstrated that the enzyme unwinds nucleic acid in discrete steps of 9.3 base—pairs each with a catalytic rate of 30 steps per second. In that study we used different constructs of nsp13 (GST and H6 constructs). GST—nsp13 showed much more efficient nucleic acid unwinding than the H6—tagged counterpart. At 0.1 second, more than 50% of the ATP is hydrolyzed by GST—nsp13 compared to less than 5% ATP hydrolysis by H6—nsp13. Interestingly, the two constructs have the same binding affinity for nucleic acids. We, therefore propose that the difference in the catalytic efficiency of these two constructs is due to the interference of ATP binding by the histidine tag at the amino—terminus of nsp13.
Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents (2009)

Pulmonary hypertension (PH) is a progressive, lethal lung disease characterized by pulmonary artery SMC (PA-SMC) hyperplasia leading to right-sided heart failure. Molecular events originating in pulmonary ECs (P-ECs) may contribute to the PA-SMC hyperplasia in PH. Thus, we exposed cultured human PA-SMC to medium conditioned by P-EC from patients with idiopathic PH (IPH) or controls and found that IPH P-EC-conditioned medium increased PA-SMC proliferation more than control P-EC medium. Levels of FGF2 were increased in the medium of IPH P-ECs over controls, while there was no detectable difference in TGF-beta1, PDGF-BB, or EGF levels. No difference in FGF2-induced proliferation or FGF receptor type 1 (FGFR1) mRNA levels was detected between IPH and control PA-SMCs. Knockdown of FGF2 in P-EC using siRNA reduced the PA-SMC growth-stimulating effects of IPH P-EC medium by 60% and control P-EC medium by 10%. In situ hybridization showed FGF2 overproduction predominantly in the remodeled vascular endothelium of lungs from patients with IPH. Repeated intravenous FGF2-siRNA administration abolished lung FGF2 production, both preventing and nearly reversing a rat model of PH. Similarly, pharmacological FGFR1 inhibition with SU5402 reversed established PH in the same model. Thus, endothelial FGF2 is overproduced in IPH and contributes to SMC hyperplasia in IPH, identifying FGF2 as a promising target for new treatments against PH.
Simulation of heat transfer in the convection section of fired process heaters (2010)

Heat transfer analysis of the radiation section in a fired process heater was carried out in order to determine the flue gas and process fluid temperatures in the zone separating the convection and the radiation sections. Such a determination is a pre-requisite for the heat transfer analysis of the convection section. A Matlab computer programme for the heat transfer analysis of the convection section was written and the results presented graphically including process heat load, the amount of absorbed heat per layer in the convection section and the temperature profiles of combustion gases, tube wall and process fluid.
A simple prior-free method for non-rigid structure-from-motion factorization (2012)

This paper proposes a simple “prior-free” method for solving non-rigid structure-from-motion factorization problems. Other than using the basic low-rank condition, our method does not assume any extra prior knowledge about the nonrigid scene or about the camera motions. Yet, it runs reliably, produces optimal result, and does not suffer from the inherent basis-ambiguity issue which plagued many conventional nonrigid factorization techniques. Our method is easy to implement, which involves solving no more than an SDP (semi-definite programming) of small and fixed size, a linear Least-Squares or trace-norm minimization. Extensive experiments have demonstrated that it outperforms most of the existing linear methods of nonrigid factorization. This paper offers not only new theoretical insight, but also a practical, everyday solution, to non-rigid structure-from-motion.
The major iron-containing protein of Legionella pneumophila is an aconitase homologous with the human iron-responsive element-binding protein (1993)

Legionella pneumophila has high iron requirements, and its intracellular growth in human monocytes is dependent on the availability of intracellular iron. To learn more about iron metabolism in L. pneumophila, we have undertaken an analysis of the iron proteins of the bacterium. We first developed an assay to identify proteins by 59Fe labelling and nondenaturing polyacrylamide gel electrophoresis. The assay revealed seven iron proteins (IPs) with apparent molecular weights of 500, 450, 250, 210, 150, 130, and 85. IP150 comigrates with superoxide dismutase activity and is probably the Fe-superoxide dismutase of L. pneumophila. IP210 is the major iron-containing protein (MICP). To identify and characterize MICP, we purified the protein and cloned and sequenced its gene. MICP is a monomeric protein containing 891 amino acids, and it has a calculated molecular mass of 98,147 Da. Analysis of the sequence revealed that MICP has two interesting homologies. First, MICP is highly homologous with the human iron-responsive element-binding protein, consistent with the hypothesis that this critical iron-regulatory molecule of humans has a prokaryotic ancestor. Second, MICP is highly homologous with the Escherichia coli aconitase and to a lesser extent with porcine heart mitochondrial aconitase. Consistent with this, we found that MICP exhibits aconitase activity. In contrast to other aconitases, MICP has a single amino acid change of a potentially deleterious type at a site thought to be critical for substrate binding and enzymatic activity. However, the specific activity of MICP is roughly comparable to that of other aconitases, suggesting that the mutation has at most a mild effect on the aconitase activity of MICP. The abundance of MICP in L. pneumophila suggests either that L. pneumophila requires high aconitase and perhaps tricarboxylic acid cycle activity or that the bacterium requires large amounts of this protein to serve an additional role in bacterial physiology. A need for large amounts of MICP, which contains four Fe atoms per molecule when fully loaded, could at least partly explain L. pneumophila's high metabolic requirement for iron.
Model-integrated development of embedded software (2003)

The paper describes a model-integrated approach for embedded software development that is based on domain-specific, multiple-view models used in all phases of the development process. Models explicitly represent the embedded software and the environment it operates in, and capture the requirements and the design of the application, simultaneously. Models are descriptive , in the sense that they allow the formal analysis, verification, and validation of the embedded system at design time. Models are also generative, in the sense that they carry enough information for automatically generating embedded systems using the techniques of program generators. Because of the widely varying nature of embedded systems, a single modeling language may not be suitable for all domains; thus, modeling languages are often domain-specific. To decrease the cost of defining and integrating domain-specific modeling languages and corresponding analysis and synthesis tools, the model-integrated approach is applied in a metamodeling architecture, where formal models of domain-specific modeling languages-called metamodels-play a key role in customizing and connecting components of tool chains. This paper discusses the principles and techniques of model-integrated embedded software development in detail, as well as the capabilities of the tools supporting the process. Examples in terms of real systems will be given that illustrate how the model-integrated approach addresses the physical nature, the assurance issues, and the dynamic structure of embedded software.
Aqueous ionic liquids and deep eutectic solvents for cellulosic biomass pretreatment and saccharification (2013)

Ionic liquids (ILs) have proven effective solvents for pretreating lignocellulose, leading to the fast saccharification of cellulose and hemicellulose. However, the high current cost of most ILs remains a major barrier to commercializing this recent approach at a practical scale. As a strategic detour, aqueous solutions of ILs are also being explored as less costly alternatives to neat ILs for cellulose pretreatment. However, limited studies on a few select IL systems are known and there remains no systematic survey of various ILs, eluding an in-depth understanding of pretreatment mechanisms afforded by aqueous IL systems. As a step toward filling this gap, this study presents results for Avicel cellulose pretreatment by neat and aqueous solutions (1.0 and 2.0 M) of 20 different ILs and three deep eutectic solvents, correlating enzymatic hydrolysis rates of pretreated cellulose with various IL properties such as hydrogen-bond basicity, polarity, Hofmeister ranking, and hydrophobicity. The pretreatment efficiencies of neat ILs may be loosely correlated to the hydrogen-bond basicity of the constituent anion and IL polarity; however, the pretreatment efficacies for aqueous ILs are more complicated and cannot be simply related to any single IL property. Several aqueous IL systems have been identified as effective alternatives to neat ILs in lignocellulose pretreatment. In particular, this study reveals that aqueous solutions of 1-butyl-3-methylimidazolium methanesulfonate ([BMIM][MeSO<sub>3</sub>]) are effective for pretreating switchgrass (<i>Panicum virgatum</i>), resulting in fast saccharification of both cellulose and hemicellulose. An integrated analysis afforded by X-ray diffraction, scanning electron microscopy, thermogravimetric analysis and cellulase adsorption isotherm of lignocellulose samples is further used to deliver a more complete view of the structural changes attending aqueous IL pretreatment.
Broadband access technologies for very high throughput wireless sensor communication networks (2010)

An efficient architecture for wireless sensor network employing 60-GHz millimeter-wave (mm-wave) wireless access technologies is proposed for systems that require very high throughput data for both transport and signal processing functions. The evolutional strategy for hierarchical system architecture and I/O signal forms of system interfaces are investigated for practical applications. The results of the proof-of-concept experimental demonstration of such very high throughput optical wireless sensor system using 60-GHz mm-wave carrying digital baseband data with different modulation formats are also presented.
Balanced Model Reduction via the Proper Orthogonal Decomposition (2002)

A new method for performing a balanced reduction of a high-order linear system is presented. The technique combines the proper orthogonal decomposition and concepts from balanced realization theory. The method of snapshotsisused to obtainlow-rank,reduced-rangeapproximationsto thesystemcontrollability and observability grammiansineitherthetimeorfrequencydomain.Theapproximationsarethenusedtoobtainabalancedreducedorder model. The method is particularly effective when a small number of outputs is of interest. It is demonstrated for a linearized high-order system that models unsteady motion of a two-dimensional airfoil. Computation of the exact grammians would be impractical for such a large system. For this problem, very accurate reducedorder models are obtained that capture the required dynamics with just three states. The new models exhibit far superiorperformancethanthosederived using a conventionalproperorthogonal decomposition. Although further development is necessary, the concept also extends to nonlinear systems.
Human polyomavirus JC control region variants in persistently infected CNS and kidney tissue. (1998)

The question of a possible role for JC virus (JCV) genomic rearrangements in the pathogenesis of progressive multifocal leukoencephalopathy (PML) was addressed by analysis of the genomic complexity and the transcriptional control region (TCR) of the JCV DNA population in persistently infected CNS and kidney tissue. After cloning of full-length viral DNA, no extensive changes were detected in the coding regions of the JCV genome by restriction analysis suggesting an intact JCV DNA population. For further analysis of the distribution of JCV subtypes, the non-coding region was amplified by PCR. Molecular analysis revealed homogeneous JCV TCR populations in almost 50% of the individuals. Heterogeneity was found in two CNS samples with three and five different JCV subtypes, respectively, and in four kidney specimens with two TCR subtypes. Altogether, seven TCR subtypes were identified. One in each group represented single promoter element TCRs without duplication of sequences. The TCR of the major variant JCV-W1 was comparable in sequence and structure to that of the PML prototype JCV Mad-1 DNA. The identification of dominant PML-derived JCV TCR subtypes in most persistently infected individuals suggests that rearrangements of the JCV TCR can be associated with the persistent state of infection. However, it appears unlikely that PML-associated JCV subtypes are generated anew in each individual host in the course of persistence. The findings rather suggest that a limited number of stable JCV subtypes circulate in different geographical regions of the world.
Lithium Lanthanum Titanium Oxides: A Fast Ionic Conductive Coating for Lithium-Ion Battery Cathodes (2012)

This work introduces Li–La–Ti–O (LLTO), which is a fast lithium-ion conductor, as an effective coating material for cathode materials used in rechargeable lithium-ion batteries. This fast Li-ion conductor is characterized by first-principles calculations showing low activation barrier for lithium diffusion at various different lithium concentrations. The morphology and the microstructure of the pristine electrode and coated electrode materials are characterized systematically, and we show clear evidence of the presence of the coating after electrochemical cycling. The coated electrodes show significantly improved rate capabilities and cycling performance, compared to the pristine electrodes. The possible reasons for such enhancements are explored experimentally using potentiostatic intermittent titration technique (PITT), electrochemical impedance spectroscopy (EIS). Because of the high lithium conductivity in the LLTO coating material, the chemical Li+ diffusion coefficient is one magnitude of order higher in the coated samples than that in the uncoated samples. In addition, the impedances of both interfacial charge transfer and Li+ transportation in the solid-electrolyte-interphase (SEI) layer are reduced up to 50% in the coated samples. Our findings provide significant insights into the role of coating regarding the improvements of electrochemical properties, as well as the potential use of solid electrolyte as an effective coating material.
An Anomalous Decomposition of Ozone in the Presence of Chlorine (1933)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Anomalous Decomposition of Ozone in the Presence of ChlorineLawrence J. Heidt, George B. Kistiakowsky, and George S. ForbesCite this: J. Am. Chem. Soc. 1933, 55, 1, 223–231Publication Date (Print):January 1, 1933Publication History Published online1 May 2002Published inissue 1 January 1933https://pubs.acs.org/doi/10.1021/ja01328a024https://doi.org/10.1021/ja01328a024research-articleACS PublicationsRequest reuse permissionsArticle Views45Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts