gebhart/patrepeval huggingface dataset:
Immunoglobulin Classes Implicated in Intestinal Disturbances of Calves Associated with Soya Protein Antigens (1979)

Abstract Calves fed diets containing soya protein develop high levels of serum antibody mainly of the IgG1 class which precipitates antigen and fixes complement. Passively acquired maternal antibody is associated with a significantly elevated response, and delaying the introduction of the soya antigen from 1 week to 4 weeks of age is associated with a significant decrease in the response. Very few calves, 3 out of 80, were found to display classical signs of immediate-type hypersensitivity to dietary soya protein. One calf, however, exhibited extreme sensitivity, with demonstrable localized anaphylaxis and PCA in recipient calves. This calf was examined in greater detail in terms of its intestinal antibody response and compared with calves exhibiting the IgG1 complement-fixing precipitin reaction which occurs as the “conventional” response to the antigen in all calves fed on the soya protein. A rationale for the surprising level of serum antibody response to the dietary antigen is based on current hypotheses relating to the cooperative action of gastrointestinal antibodies and enzymes. Examination of the immunoglobulin classes present in the secretions of Thiry Vella loops demonstrated a low level of specific antibody associated with IgM and IgA classes. Perfusion of the loops with soya protein extracts resulted in a dramatic release of antibody activity in the hypersensitive calf with a change of specific activity to the IgG class. This antibody secretion coincided with the detection of a transient homocytotropic antibody response in the loop secretion. In calves exhibiting the “conventional” IgG1 blood serum antibody response, insignificant amounts of antibody of any immunoglobulin class were released into the lumen.
Uniform Representation Model for Metadata of Data Warehouse (2002)

A uniform metadata representation is introduced for heterogeneous databases, multi media information and other information sources. Some features about metadata are analyzed. The limitation of existing metadata model is compared with the new one. The metadata model is described in XML which is fit for metadata denotation and exchange. The well structured data, semi structured data and those exterior file data without structure are described in the metadata model. The model provides feasibility and extensibility for constructing uniform metadata model of data warehouse.
High-Resolution Electrospray Ionization Orthogonal-Injection Time-of-Flight Mass Spectrometer (2000)

A concept of an “ideal” orthogonal-injection time-of-flight (O-TOF) mass spectrometer is proposed and a new high-resolution O-TOF mass spectrometer with an electrospray ion source and a molecule-ion reactor is described. The instrument design was optimized for high resolution and sensitivity using the concept of an ideal O-TOF mass spectrometer. A mass resolving power of about 20,000 (full width at half maximum) and a mass measurement accuracy in the 10 ppm range is demonstrated.
Time-domain steady-state simulation of frequency-dependent components using multi-interval Chebyshev method (2002)

Simulation of RF circuits often demands analysis of distributed component models that are described via frequency-dependent multi-port Y, Z, or S parameters. Frequency-domain methods such as harmonic balance are able to handle these components without difficulty, while they are more difficult for time-domain simulation methods to treat. In this paper, we propose a hybrid frequency-time approach to treat these components in steady-state time-domain simulations. Efficiency is achieved through the use of the multi-interval Chebyshev (MIC) simulation method and a low-order rational-fitting model for preconditioning matrix-implicit Krylov-subspace solvers.
Frequency of gene sequences necessary for pyelonephritis-associated pili expression among isolates of Enterobacteriaceae from human extraintestinal infections (1984)

Bacteria representing eight genera of the Enterobacteriaceae were collected from human extraintestinal infections and examined to determine whether they contained gene sequences necessary for expression of a pili type often associated with bacteria causing human pyelonephritis. Escherichia coli isolated from most of the extraintestinal sites were frequently found to possess pap-related DNA sequences. Isolates which possessed these sequences were often found to exhibit D-mannose-resistant hemagglutination of human erythrocytes and to have surface antigens related to P pili.
The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. (1991)

A chromosomal translocation in a T-cell leukemia involving the short arm of human chromosome 11 at band 11p15 disrupts the rhombotin gene. This gene encodes a protein with duplicated cysteine-rich regions called LIM domains, which show homology to zinc-binding proteins and to iron-sulfur centers of ferredoxins. Two homologues of the rhombotin gene have now been isolated. One of these, designated Rhom-2, is located on human chromosome 11 at band 11p13, where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene. Human and mouse Rhom-2 are highly conserved and, like rhombotin, encode two tandem cysteine-rich LIM domains. Rhom-2 mRNA is expressed in early mouse development in central nervous system, lung, kidney, liver, and spleen but only very low levels occur in thymus. The other gene, designated Rhom-3, is not on chromosome 11 but also retains homology to the LIM domain of rhombotin. Since the Rhom-2 gene is such a common site of chromosomal damage in T-cell tumors, the consistency of translocations near the rhombotin gene was further examined. A second translocation adjacent to rhombotin was found and at the same position as in the previous example. Therefore, chromosome bands 11p15 (rhombotin) and 11p13 (Rhom-2) are consistent sites of chromosome translocation in T-cell leukemia, with the 11p15 target more rarely involved. The results define the rhombotin gene family as a class of T-cell oncogenes with duplicated cysteine-rich LIM domains.
Stimulation sites in the subthalamic nucleus and clinical improvement in Parkinson's disease: a new approach for active contact localization (2016)

OBJECTIVE Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is widely used in patients with Parkinson's disease (PD). However, which target area of this region results in the highest antiparkinsonian efficacy is still a matter of debate. The aim of this study was to develop a more accurate methodology to locate the electrodes and the contacts used for chronic stimulation (active contacts) in the subthalamic region, and to determine the position at which stimulation conveys the greatest clinical benefit. METHODS The study group comprised 40 patients with PD in whom bilateral DBS electrodes had been implanted in the STN. Based on the Morel atlas, the authors created an adaptable 3D atlas that takes into account individual anatomical variability and divides the STN into functional territories. The locations of the electrodes and active contacts were obtained from an accurate volumetric assessment of the artifact using preoperative and postoperative MR images. Active contacts were positioned in the 3D atlas using stereotactic coordinates and a new volumetric method based on an ellipsoid representation created from all voxels that belong to a set of contacts. The antiparkinsonian benefit of the stimulation was evaluated by the reduction in the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) score and in the levodopa equivalent daily dose (LEDD) at 6 months. A homogeneous group classification for contact position and the respective clinical improvement was applied using a hierarchical clustering method. RESULTS Subthalamic stimulation induced a significant reduction of 58.0% ± 16.5% in the UPDRS-III score (p < 0.001) and 64.9% ± 21.0% in the LEDD (p < 0.001). The greatest reductions in the total and contralateral UPDRS-III scores (64% and 76%, respectively) and in the LEDD (73%) were obtained when the active contacts were placed approximately 12 mm lateral to the midline, with no influence of the position being observed in the anteroposterior and dorsoventral axes. In contrast, contacts located about 10 mm from the midline only reduced the global and contralateral UPDRS-III scores by 47% and 41%, respectively, and the LEDD by 33%. Using the ellipsoid method of location, active contacts with the highest benefit were positioned in the rostral and most lateral portion of the STN and at the interface between this subthalamic region, the zona incerta, and the thalamic fasciculus. Contacts placed in the most medial regions of the motor STN area provided the lowest clinical efficacy. CONCLUSIONS The authors report an accurate new methodology to assess the position of electrodes and contacts used for chronic subthalamic stimulation. Using this approach, the highest antiparkinsonian benefit is achieved when active contacts are located within the rostral and the most lateral parts of the motor region of the STN and at the interface of this region and adjacent areas (zona incerta and thalamic fasciculus).
Electronic Package Failure Analysis Using TDR (2000)

Abstract The visual nature of Time Domain Reflectometry (TDR) makes it a very natural technology that can assist with fault location in BGA packages, which typically have complex interweaving layouts that make standard failure analysis techniques, such as acoustic imaging and X-ray, less effective and more difficult to utilize. This article discusses the use of TDR for package failure analysis work. It analyzes in detail the TDR impedance deconvolution algorithm as applicable to electronic packaging fault location work, focusing on the opportunities that impedance deconvolution and the resulting true impedance profile opens up for such work. The article examines the TDR measurement accuracy and the comparative package failure analysis, and presents three main considerations for package failure analysis. It also touches upon the goal and the task of the failure analysts and TDR's specific signatures for the open and short connections.
THE DISINFECTION OF DRINKING WATER: With a Description of a New Substance for the Preparation of Stable Tablets for the Sterilization of Polluted Water (1917)

fluid, and so arrests osmosis anid diffusion in the case of the parietal peritoneal vessels. This arrest of osmosis occurs at a certain stage in each animal, depending entirely upon tlle rate of output of lymph.
Use of Weak Perturbing Radio-Frequency Fields in Nuclear Magnetic Double Resonance (1962)

A theory is developed to explain high-resolution nuclear magnetic resonance spectra observed in the presence of a second weak rf field at ω2. When ω2 is set on a nondegenerate transition frequency and the rest of the spectrum recorded by sweeping the frequency of the investigating rf field, any transitions that have an energy level in common with the perturbed transition will be split into doublets. If magnetic field inhomogeneities exceed the natural linewidth, the line profile of the doublets gives information about the ordering of the three energy levels involved. Good agreement with the theory has been obtained in experiments on two-spin and three-spin proton systems where the energy-level diagram is already known. The method has been used to establish the ordering of the energy levels of the ABC system of protons in methyltrivinylsilane and the analysis has been completed by two independent methods. Some of the special effects which arise when double-resonance spectra are recorded by sweeping the magnetic field have been examined and discussed.
Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides (2017)

An amyloidogenic peptide, amyloid-β (Aβ), has been implicated as a contributor to the neurotoxicity of Alzheimer's disease (AD) that continues to present a major socioeconomic burden for our society. Recently, the use of metal complexes capable of cleaving peptides has arisen as an efficient tactic for amyloid management; unfortunately, little has been reported to pursue this strategy. Herein, we report a novel approach to validate the hydrolytic cleavage of divalent metal complexes toward two major isoforms of Aβ (Aβ<sub>40</sub> and Aβ<sub>42</sub>) and tune their proteolytic activity based on the choice of metal centers (M = Co, Ni, Cu, and Zn) which could be correlated to their anti-amyloidogenic properties. Such metal-dependent tunability was facilitated employing a tetra-N-methylated cyclam (TMC) ligand that imparts unique geometric and stereochemical control, which has not been available in previous systems. Co(II)(TMC) was identified to noticeably cleave Aβ peptides and control their aggregation, reporting the first Co(II) complex for such reactivities to the best of our knowledge. Through detailed mechanistic investigations by biochemical, spectroscopic, mass spectrometric, and computational studies, the critical importance of the coordination environment and acidity of the aqua-bound complexes in promoting amide hydrolysis was verified. The biological applicability of Co(II)(TMC) was also illustrated via its potential blood-brain barrier permeability, relatively low cytotoxicity, regulatory capability against toxicity induced by both Aβ<sub>40</sub> and Aβ<sub>42</sub> in living cells, proteolytic activity with Aβ peptides under biologically relevant conditions, and inertness toward cleavage of structured proteins. Overall, our approaches and findings on reactivities of divalent metal complexes toward Aβ, along with the mechanistic insights, demonstrate the feasibility of utilizing such metal complexes for amyloid control.
Arbuckle, James (d. 1742) (1999)

Arbuckle, James James Arbuckle was born in Belfast and died on 16 January 1742 in Dublin. He was crippled from an early age. He was educated at Glasgow University (MA, 1720), where he remained until at least the spring of 1724 studying for the ministry, but he never took up this calling. He is best
Some Bibliographical Aids to the Use of British Government Publications (1931)

It is a well recognized fact that government publications are frequently the most valuable, and sometimes practically the only, reliable source of information on many phases of political, social, and economic life. Every bibliographical aid to their use, therefore, is to be highly welcomed by the student of government; and, fortunately for him, these aids are being rapidly multiplied. A noteworthy illustration is the List of Serial Publications of Foreign Governments, 1815–1929 , now being prepared by Miss “Winifred Gregory under the general direction of a joint committee of the American Council of Learned Societies, the National Eesearch Council, and the American Library Association. Under each country will be listed, in a classified arrangement, the reports and other serials which record governmental activities since 1815. Section two of the preliminary checking edition of the List is devoted to the British Overseas Empire (except Canada). Angus Fletcher, librarian of the British Library of Information in New York, points out that “the publication of official documents is a relatively recent development in English parliamentary history. It was not until 1837 that official documents were finally made available to the public, in the form of the regularly issued Parliamentary Papers as we know them today. The publication of Non-Parliamentary Papers is of stilllater origin.” The establishment of His Majesty's Stationery Office was a result of Burke's Act for Economical Reform in 1782, prior to which time the service of this office had been granted as a monopoly to persons in favor at court. The student entering on a study of British public documents can well afford to review the very readable and valuable historical account of the records of Parliament given by Sir Courtney Ilbert, wherein he traces the development of the written reports of the journals and debates from their beginnings.
Securing information display by use of visual cryptography (2003)

We propose a secure display technique based on visual cryptography. The proposed technique ensures the security of visual information. The display employs a decoding mask based on visual cryptography. Without the decoding mask, the displayed information cannot be viewed. The viewing zone is limited by the decoding mask so that only one person can view the information. We have developed a set of encryption codes to maintain the designed viewing zone and have demonstrated a display that provides a limited viewing zone.
SRPX2 mutations in disorders of language cortex and cognition (2006)

The rolandic and sylvian fissures divide the human cerebral hemispheres and the adjacent areas participate in speech processing. The relationship of rolandic (sylvian) seizure disorders with speech and cognitive impairments is well known, albeit poorly understood. We have identified the Xq22 gene SRPX2 as being responsible for rolandic seizures (RSs) associated with oral and speech dyspraxia and mental retardation (MR). SRPX2 is a secreted sushi-repeat containing protein expressed in neurons of the human adult brain, including the rolandic area. The disease-causing mutation (N327S) resulted in gain-of-glycosylation of the secreted mutant protein. A second mutation (Y72S) was identified within the first sushi domain of SRPX2 in a male with RSs and bilateral perisylvian polymicrogyria and his female relatives with mild MR or unaffected carrier status. In cultured cells, both mutations were associated with altered patterns of intracellular processing, suggesting protein misfolding. In the murine brain, Srpx2 protein expression appeared in neurons at birth. The involvement of SRPX2 in these disorders suggests an important role for SRPX2 in the perisylvian region critical for language and cognitive development.
Gold(I)-Catalyzed Hydroaminative Cyclization Leading to 2,5-Dihydroisoxazole (2007)

Gold(I)-catalyzed intramolecular hydroamination of O-propargyl-N-Boc-hydroxylamine is reported. The present ­method provides a novel, catalytic, and mild approach to 2,5-dihydroisoxazole derivatives. In addition, a mechanism of N-O cleavage as a side reaction as well as desired cyclization is proposed.
Machine Learning based Timeliness-Guaranteed and Energy-Efficient Task Assignment in Edge Computing Systems (2019)

The proliferation in the use of the Internet of Things (IoT) and Machine Learning (ML) techniques in edge computing systems have paved the way of using Intelligent Cognitive Assistants (ICA) for assisting people in working, learning, transportation, healthcare, and other activities. A challenge here is how to schedule application tasks between the three tiers in the edge computing system (i.e., remote cloud, fog and edge devices) according to several considered factors such as latency, energy, and bandwidth consumption. However, the state-of-the-art approaches for this challenge fall short in providing a schedule in real time for critical ICA tasks due to complex calculation phase. In this paper, we propose a novel ReInforcement Learning based Task Assignment approach, RILTA, that ensures the timeliness guaranteed execution of ICA tasks with high energy efficiency. We first formulate the task-scheduling problem in the edge computing systems considering timeliness and energy consumption in ICA applications. We then propose a heuristic for solving the problem and design the reinforcement model based on the output of the proposed heuristic. Our simulation results show that RILTA can reduce the task processing time and energy consumption with higher timeliness guarantee in comparison to other existing methods by 13 - 22% and 1 - 10% respectively.
Visual cortex on the GPU: Biologically inspired classifier and feature descriptor for rapid recognition (2008)

We present a biologically motivated classifier and feature descriptors that are designed for execution on Single Instruction Multi Data hardware and are applied to high speed multiclass object recognition. Our feature extractor uses a cellular tuning approach to select the optimal Gabor filters to process a given input, followed by the computation of scale and rotation-invariant features that are sparsified with a lateral inhibition mechanism. Neighboring features are pooled into feature hierarchies whose resonant properties are used to select the most representative hierarchies for each object class. The feature hierarchies are used to train a novel form of Adaptive Resonance Theory classifier for multiclass object recognition. Our model has unprecedented biologically plausibility at all stages and uses the programmable Graphics Processing Unit (GPU) for high speed feature extraction and object classification. We demonstrate the speedup achieved with the use of the GPU and test our model on the Caltech 101 and 15 Scene datasets, where our system achieves state-of-the-art performance.
Development of Robotic Gloves for Hand Rehabilitation Post-Stroke (2015)

This paper presents the hardware and software developments that have been achieved and implemented in the robotic gloves for hand rehabilitation post-stroke. The practical results are shown that prove the functionalities of the robotic gloves in common operating conditions. This work focused on development of a lightweight and low-cost robotic glove that patients can wear and use to recover hand functionality. We developed some structures for the robotic glove, as exoskeleton and as soft robotic glove. The paper presents a comparison of these structures.
RECORDINGS (1988)

Journal Article RECORDINGS Get access Antonio Vivaldi IN TURBATO MARE IRATO RV627 CONCERTO MADRIGALESCO IN D MINOR, RV129 CONCERTO IN G MINOR RV157 CONCERTO ALLA RUSTICA IN G MAJOR RV15I LUNGI DAL VAGO VOLTO RV680 MAGNIFICAT, RV610 Emma Kirkby (soprano) The Tafelmusik Baroque Orchestra. The Tafelmusik Chamber Choir, directed by Jean Lamon Hyperion A66247 (rec 1987) LAUDATE PUERI, RV601, NISI DOMINUS, RV608 Lynne Dawson (soprano). Christopher Robson (countertenor), The King's Consort, directed by Robert King Meridian KE77129 (rec 1986) Eric Cross Eric Cross Search for other works by this author on: Oxford Academic Google Scholar Early Music, Volume XVI, Issue 3, August 1988, Pages 471–472, https://doi.org/10.1093/earlyj/XVI.3.471 Published: 01 August 1988
Loss of FilaminC (FLNc) Results in Severe Defects in Myogenesis and Myotube Structure (2006)

FilaminC (FLNc) is the muscle-specific member of a family of actin binding proteins. Although it interacts with many proteins involved in muscular dystrophies, its unique role in muscle is poorly understood. To address this, two models were developed. First, FLNc expression was stably reduced in C2C12 myoblasts by RNA interference. While these cells start differentiation normally, they display defects in differentiation and fusion ability and ultimately form multinucleated "myoballs" rather than maintain elongated morphology. Second, a mouse model carrying a deletion of last 8 exons of Flnc was developed. FLNc-deficient mice die shortly after birth, due to respiratory failure, and have severely reduced birth weights, with fewer muscle fibers and primary myotubes, indicating defects in primary myogenesis. They exhibit variation in fiber size, fibers with centrally located nuclei, and some rounded fibers resembling the in vitro phenotype. The similarity of the phenotype of FLNc-deficient mice to the filamin-interacting TRIO null mice was further confirmed by comparing FLNc-deficient C2C12 cells to TRIO-deficient cells. These data provide the first evidence that FLNc has a crucial role in muscle development and maintenance of muscle structural integrity and suggest the presence of a TRIO-FLNc-dependent pathway in maintaining proper myotube structure.