gebhart/patrepeval huggingface dataset:
The Man Who Tells You He Understands Series Will Lie to You About Other Things as Well (2013)

My good friend Scott Ludwig, a font of southern aphorisms, is known to have observed “A man who tells you he is in charge of his household will lie to you about other things as well.” While it is beyond my skill set to assess the universality of this obvious generalization, I am confident that anyone representing that they truly understand the “series” as utilized in certain LLC, limited partnership and business/statutory trust acts is at a minimum overestimating their capabilities. Simply put, consequent to the disparate elements of series between the various acts and the many unresolved questions, understanding is simply at this time not possible.
BDNF stimulates expression, activity and release of tissue‐type plasminogen activator in mouse cortical neurons (1999)

Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor involved in neuronal development and synaptic plasticity. Although the physiological effects of BDNF have been examined in detail, target proteins which mediate its actions remain largely unknown. Here, we report that BDNF stimulates the expression of tissue-type plasminogen activator (tPA) in primary cultures of cortical neurons in a time- and concentration-dependent manner. Among the other members of the neurotrophin family, neurotrophin-4 (NT-4) and to a lesser extent neurotrophin-3 (NT-3) also increased tPA mRNA expression, while nerve growth factor (NGF) was devoid of any effect. Induction of tPA expression by BDNF is accompanied by an increase in the proteolytic activity of tPA associated with cortical neurons and a release of tPA into the extracellular space. Release of tPA induced by BDNF depends on extracellular Ca2+ since it is markedly reduced in the presence of ethylene glycol-bis(beta-aminoethylether)-N,N,N',N'-tetraacetic acid (EGTA). Up-regulation of tPA expression by BDNF is followed by the induction of plasminogen activator inhibitor 2 (PAI-2), an inhibitor of tPA. Together these results suggest that activation of tPA by BDNF may contribute to structural changes associated with neuronal development or synaptic plasticity.
Biogeochemistry of arsenic in natural waters: the importance of methylated species (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiogeochemistry of arsenic in natural waters: the importance of methylated speciesLinda C. D. Anderson and Kenneth W. BrulandCite this: Environ. Sci. Technol. 1991, 25, 3, 420–427Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://pubs.acs.org/doi/10.1021/es00015a007https://doi.org/10.1021/es00015a007research-articleACS PublicationsRequest reuse permissionsArticle Views764Altmetric-Citations185LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Expression of codon optimized genes in microbial systems: current industrial applications and perspectives (2014)

The efficient production of functional proteins in heterologous hosts is one of the major bases of modern biotechnology. Unfortunately, many genes are difficult to express outside their original context. Due to their apparent "silent" nature, synonymous codon substitutions have long been thought to be trivial. In recent years, this dogma has been refuted by evidence that codon replacement can have a significant impact on gene expression levels and protein folding. In the past decade, considerable advances in the speed and cost of gene synthesis have facilitated the complete redesign of entire gene sequences, dramatically improving the likelihood of high protein expression. This technology significantly impacts the economic feasibility of microbial-based biotechnological processes by, for example, increasing the volumetric productivities of recombinant proteins or facilitating the redesign of novel biosynthetic routes for the production of metabolites. This review discusses the current applications of this technology, particularly those regarding the production of small molecules and industrially relevant recombinant enzymes. Suggestions for future research and potential uses are provided as well.
Ion beam diagnostics and neutralization Final report, 14 Feb. 1966 - 21 Aug. 1967 (1967)

Mercury discharge neutralizer, for potential use mercury electron bombardment thrustor in electric propulsion systems
Three-Dimensional Paper-Based Microfluidic Device for Assays of Protein and Glucose in Urine (2013)

The first step in curing a disease is being able to detect the disease effectively. Paper-based microfluidic devices are biodegradable and can make diagnosing diseases cost-effective and easy in almost all environments. We created a three-dimesnional (3D) paper device using wax printing fabrication technique and basic principles of origami. This design allows for a versatile fabrication technique over previously reported patterning of SU-8 photoresist on chromatography paper by employing a readily available wax printer. The design also utilizes multiple colorimetric assays that can accommodate one or more analytes including urine, blood, and saliva. In this case to demonstrate the functionality of the 3D paper-based microfluidic system, a urinalysis of protein and glucose assays is conducted. The amounts of glucose and protein introduced to the device are found to be proportional to the color change of each assay. This color change was quantified by use of Adobe Photoshop. Urine samples from participants with no pre-existing health conditions and one person with diabetes were collected and compared against synthetic urine samples with predetermined glucose and protein levels. Utilizing this method, we were able to confirm that both protein and glucose levels were in fact within healthy ranges for healthy participants. For the participant with diabetes, glucose was found to be above the healthy range while the protein level was in the healthy range.
Magnesium Hydroxide in the Petroleum Industry (1932)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMagnesium Hydroxide in the Petroleum IndustryF. T. Gardner and E. C. HigginsCite this: Ind. Eng. Chem. 1932, 24, 10, 1141–1146Publication Date (Print):October 1, 1932Publication History Published online1 May 2002Published inissue 1 October 1932https://pubs.acs.org/doi/10.1021/ie50274a012https://doi.org/10.1021/ie50274a012research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Synthesis and Crystal Structure of Ternary SulfidesA3MS4withA=Na, Rb andM=Nb, Ta (1998)

The new ternary sulfides Na3MS4and Rb3MS4(M=Nb, Ta) were prepared from tantalum nitride or niobium powder in the respective alkali metal polysulfide melt. Both sodium sulfides crystallize in form of yellow (Nb) or yellow-orange (Ta) needles in the orthorhombic space groupFdd2 withZ=32 anda=27.3034(4) Å,b=28.4662(1) Å, andc=7.9642(1) Å,R/Rw=0.024/0.048 forM=Nb anda=27.2322(2) Å,b=28.4264(2) Å, andc=7.9634(6) Å,R/Rw=0.066/0.177 forM=Ta. The rubidium sulfides were obtained as yellow (Nb) and orange (Ta) crystals with irregular shape. They crystallize in the orthorhombic space groupPnmawithZ=4 anda=9.6109(6) Å,b=11.1013(7) Å, andc=9.6390(6) Å,R/Rw=0.030/0.072 forM=Nb anda=9.6084(5) Å,b=11.1067(6) Å, andc=9.6426(5) Å,R/Rw=0.031/0.070 forM=Ta. The structures of all four compounds are built by stacking isolatedMS3−4units with the alkali metal ions.
Indigo production by naphthalene-degrading bacteria (2000)

A wild‐type naphthalene‐degrading strain Pseudomonas putida RKJ1 and two recombinant strains each of Ps. putida and Escherichia coli carrying the genes for naphthalene degradation on a recombinant plasmid pRKJ3, produced indigo and indirubin pigments from indole. Naphthalene, salicylate and IPTG induced cells of naphthalene‐degrading recombinant bacteria produced up to two times higher indigo compared with the uninduced cells. The maximum rates of indigo formation by Ps. putida RKJ1, Ps. putida RKJ5/pRKJ3, Ps. putida KT2442/pRKJ3, E. coli TB1/pRKJ3 and E. coli AB1157/pRKJ3 were 0·60, 0·80, 0·60, 1·20 and 1·50 nmol min−1 mg dry biomass−1, respectively, using indole as the substrate. The apparent Km values of indigo formation by these same bacteria were 0·22, 0·15, 0·10, 0·21 and 0·20 mmol l−1, respectively, again using indole as the substrate. The present study revealed that E. coli AB1157 was the most efficient of the hosts tested for the expression of the plasmid encoded genes (pRKJ3) from the wild‐type strain Ps. putida RKJ1. In addition, both recombinant E. coli strains were capable of producing indigo directly from nutrient medium.
Introduction to the order Diptera — mosquitoes, horseflies, houseflies, tsetse flies etc (1980)

Adult insects belonging to the order Diptera may be readily recognised by the presence of only one pair of functional wings, not two pairs as in butterflies and moths, and wasps and bees.
Numerical analysis of the coupled circuit and cooling holes for an electromagnetic shaker (2005)

This paper presents a time-stepping shaker modeling scheme. The new method improves the accuracy of analysis of armature-position-dependent inductances and force factors, analysis of axial variation of current density in copper plates (short-circuited turns), and analysis of cooling holes in the magnetic circuit. Linear movement modeling allows armature position to be precisely included in the shaker analysis. A more accurate calculation of eddy currents in the coupled circuit is in particular crucial for the shaker analysis in a mid-or high-frequency operation range. Large currents in a shaker, including eddy currents, incur large Joule losses, which in turn require the use of a cooling system to keep temperature at bay. Sizable cooling holes have influence on the saturation state of iron poles, and hence have to be properly taken into account.
Autonomic Networking Use Case for Network Bootstrap (2014)

This document describes a use case for a specific autonomic
functionality: Securely bootstrapping new devices into a network,
without the need for pre-staging. The goal is to illustrate a
requirement from network operators, and to illustrate how autonomic
approaches can solve this use case.
The first double oxidative addition of CH2Cl2 to a metal complex: facile synthesis of [Ru(CH2)Cl2{P(C6H11) 3}2] (1997)

[Ru(H) 2 (H 2 ) 2 L 2 ] [L = P(C 6 H 11 ) 3 ] serves as a formal source of zerovalent ‘RuL 2 ’, and undergoes unprecedented oxidative addition of both C–Cl bonds of CH 2 Cl 2 to a single metal center, providing a convenient synthesis of the alkene metathesis catalyst [Ru(CH 2 )Cl 2 L 2 ].
A Reviev on Advances in Rapid Prototype 3D Printing of Multi-Functional Applications (2017)

The present paper is providing overview information in rapid prototype manufacturing process of 3D printing for multifunctional applications. To make precise and useful products, 3D printers are attractive method over 2D printers because of multiple types of material within a single build-up cycle. This technology allows the printing of multiple colors. The multi-functional material printers work for a single family of a materials like polymers, for instance and are largely used for prototyping applications. Various factors mostly generated to materials themselves, which make further improvement in prototype printing. Mostly processes are built-up around an ideal material that responds to a narrow range of temperature inputs or light frequency. Using heat or light, printers often liquefy or solidify substances to manipulate the material into specific forms.
Controlled release application of multilamellar vesicles: a novel drug delivery approach (2010)

A novel multilamellar vesicular delivery system was developed for the controlled release application. Multilamellar vesicles were prepared by thin film hydration and converted into proliposomes by freeze-drying. A model drug metoclopramide, a highly hydrophilic drug, was successfully encapsulated into proliposomes. The proliposomes produced were non-sticky, free-flowing powders. The proliposomes were formulated into a unit dosage form by combining with various excipients. The effect of different compositions such as type and concentration of phospholipid or hydrophilic polymer was investigared to optimize the formulation. The formation of multilamellar vesicles was confirmed by observing the process of hydration of proliposomes under an optical microscope. The spherical shape of vesicles was confirmed by transmission electron microscopy (TEM) and mean particle sizes were in the range of 1.3-2.5 microm, as measured by dynamic light scattering technique. Differential scanning calorimetry (DSC) study of formulations was conducted to understand the crystalline nature of drug in the vesicles. The results indicated a molecular level dispersion of drug into proliposomes with encapsulation efficiency up to 43%. Critical formulation parameters were identified to obtain a near zero order in vitro release pattern. Proliposomal formulations produced were suitable as multiparticulate drug delivery systems for the controlled release of a highly hydrophilic molecule.
Evaluation of Etiquette Strategies to Adapt Feedback In Affect-Aware Tutoring (2016)

The purpose of this research is to investigate how to mitigate user frustration and improve task performance in the context of human-computer interaction (HCI). Even though user frustration plays a role in many aspects of HCI and studies have looked into the consequences of frustration in various fields, the ways to mitigate frustration are less deeply examined. Once the system has the ability to understand and include user emotions as factors in HCI, the interaction between the user and the computer system could be adapted if the computers are able to modify its behavior with users in appropriate ways to further joint performance. Specifically, a preliminary study was conducted to explore the task performance, motivation, and confidence implications of changing the interaction between the human and the computer via different etiquette strategies. Participants solved a total of twenty mathematics problems under different frustration condition with feedback given in different styles of etiquette. Changing etiquette strategies in tutoring led to changes in performance, motivation, and confidence. The most effective etiquette strategies changed when users were frustrated. This work provides the foundation for the design of adaptive intelligent tutoring system based on etiquette strategies.
A security architecture for application session handoff (2003)

Ubiquitous computing across a variety of wired and wireless connections still lacks an effective security architecture. In our research work, we address the specific issue of designing and building a security architecture for application session handoff, a functionality which we envision will be a key component enabling ubiquitous computing. Our architecture incorporates a number of proven approaches into the new context of ubiquitous computing. We employ the Bell-LaPadula (1976) and capability models to realise access control and adopt public key infrastructure (PKI)-based approaches to provide efficient and authenticated end-to-end security. To demonstrate the effectiveness of our design, we implemented an application enabled with this security architecture and showed that it incurred low latency.
Mycoplasmas as cofactors in infection due to the human immunodeficiency virus. (1993)

Results obtained in vitro suggest that mycoplasmas act as cofactors with the human immunodeficiency virus (HIV) in the development of AIDS. Mycoplasmas, including Mycoplasma fermentans, Mycoplasma pirum, and Mycoplasma penetrans have since been isolated from HIV-infected individuals. In addition, M. fermentans has been detected by different investigators in numerous tissues and in the blood of HIV-infected patients. Higher titers of antibodies to M. penetrans have also been found in HIV-infected patients as compared with noninfected individuals. These mycoplasmas have been shown to have the capacity to invade cells and to be potent immunomodulators. Although there is no doubt that mycoplasmas are found in HIV-infected individuals and eventually produce systemic infections, their pathogenic role in association with HIV remains to be determined.
New approaches for understanding mechanisms of drug resistance in schistosomes (2013)

Schistosomes are parasitic flatworms that cause schistosomiasis, a neglected tropical disease that affects hundreds of millions worldwide. Treatment and control of schistosomiasis relies almost entirely on the single drug praziquantel (PZQ), making the prospect of emerging drug resistance particularly worrisome. This review will survey reports of PZQ (and other drug) resistance in schistosomes and other platyhelminths, and explore mechanisms by which drug resistance might develop. Newer genomic and post-genomic strategies that offer the promise of better understanding of how drug resistance might arise in these organisms will be discussed. These approaches could also lead to insights into the mode of action of these drugs and potentially provide markers for monitoring the emergence of resistance.
Enzyme Inhibition Activities of Ethanol Extracts from Germinating Rough Rice (Oryza sativar L.) (2013)

본 연구에서는 발아기간 및 부위별 벼 추출물에 대한 다양한 효소활성 저해효과를 조사하였다. 발아기간은 6일까지로 하였고, 발아된 벼는 왕겨＋싹 부위와 현미로 나누어 80% ethanol로 환류 추출하였다. α-Glucosidase 저해활성은 왕겨＋싹 추출물에서 발아 전 26.32%에서 발아 5일차 39.38%로 증가하였으며, α-amylase 저해활성은 왕겨＋싹 추출물에서 발아 전 59.98%에서 발아 5일차 75.32%로 증가하였고, DPP-4 저해활성 또한 왕겨＋싹 추출물에서 발아 전 38.80%에서 발아 5일차 47.77%로 증가하여 발아에 의해 효소활성저해가 증가하였다. ACE 저해활성은 왕겨＋싹 추출물에서 가장 높았으며 발아에 의해 증가하였다. Xanthine oxidase 저해활성은 발아가 진행됨에 따라 감소하였다. Lipase 저해활성은 발아 4일차 왕겨＋싹 추출물이 36.78%로 무발아31.72%에 비하여 증가하였다. 본 연구결과 벼를 발아시킬 경우 왕겨＋싹에서 성인병 관료 효소를 억제하는 성분이 증가함을 알 수 있었으며, 추후에 어떠한 성분에 의한 것인지에 대한 연구가 수행되어야 할 것으로 판단된다.
Light extraction technologies for high-efficiency GaInN-LED devices (2003)

Data are presented for an GaInN based thinfilm LED. The LED is fabricated by transferring the epilayers with laser lift off from sapphire to a GaAs host substrate. In combination with efficient surface roughening and highly reflective p-mirror metallisation an extraction efficiency of 70% and wall plug efficiency of 24% at 460nm have been shown. The chips showed 12mW @ 20mA with a Voltage of 3.2V. The technology is scalable from small size LEDs to high current Chips and is being transferred to mass production.
B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>‐Catalyzed Selective Chlorination of Hydrosilanes (2017)

The chlorination of Si-H bonds often requires stoichiometric amounts of metal salts in conjunction with hazardous reagents, such as tin chlorides, Cl<sub>2</sub> , and CCl<sub>4</sub> . The catalytic chlorination of silanes often involves the use of expensive transition-metal catalysts. By a new simple, selective, and highly efficient catalytic metal-free method for the chlorination of Si-H bonds, mono-, di-, and trihydrosilanes were selectively chlorinated in the presence of a catalytic amount of B(C<sub>6</sub> F<sub>5</sub> )<sub>3</sub> or Et<sub>2</sub> O⋅B(C<sub>6</sub> F<sub>5</sub> )<sub>3</sub> and HCl with the release of H<sub>2</sub> as a by-product. The hydrides in di- and trihydrosilanes could be selectively chlorinated by HCl in a stepwise manner when Et<sub>2</sub> O⋅B(C<sub>6</sub> F<sub>5</sub> )<sub>3</sub> was used as the catalyst. A mechanism is proposed for these catalytic chlorination reactions on the basis of competition experiments and density functional theory (DFT) calculations.
MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses (2020)

ABSTRACT Integrative multi-omics analyses can empower more effective investigation and complete understanding of complex biological systems. Despite recent advances in a range of omics analyses, multi-omic measurements of the same sample are still challenging and current methods have not been well evaluated in terms of reproducibility and broad applicability. Here we adapted a solvent-based method, widely applied for extracting lipids and metabolites, to add proteomics to mass spectrometry-based multi-omics measurements. The m etabolite, p rotein, and l ipid ex traction (MPLEx) protocol proved to be robust and applicable to a diverse set of sample types, including cell cultures, microbial communities, and tissues. To illustrate the utility of this protocol, an integrative multi-omics analysis was performed using a lung epithelial cell line infected with Middle East respiratory syndrome coronavirus, which showed the impact of this virus on the host glycolytic pathway and also suggested a role for lipids during infection. The MPLEx method is a simple, fast, and robust protocol that can be applied for integrative multi-omic measurements from diverse sample types (e.g., environmental, in vitro , and clinical). IMPORTANCE In systems biology studies, the integration of multiple omics measurements (i.e., genomics, transcriptomics, proteomics, metabolomics, and lipidomics) has been shown to provide a more complete and informative view of biological pathways. Thus, the prospect of extracting different types of molecules (e.g., DNAs, RNAs, proteins, and metabolites) and performing multiple omics measurements on single samples is very attractive, but such studies are challenging due to the fact that the extraction conditions differ according to the molecule type. Here, we adapted an organic solvent-based extraction method that demonstrated broad applicability and robustness, which enabled comprehensive proteomics, metabolomics, and lipidomics analyses from the same sample.
Pinpointing new potential of mature fields in Mexico: An example from Vernet Field (2003)

In 2002, Compañía Mexicana de Geofísica (CMG) conducted an integrated study of Vernet Field. Located in the southern part of Macuspana Basin and discovered in the 1930s, this field has produced oil and gas from 13 intervals in approximately 25 wells. Macuspana, a mature basin in southeast Mexico where hydrocarbon production dates to the early part of the 20th century, is predominantly gas-prone with production of 5.4 trillion ft3 of gas and limited oil from Mio-Pliocene clastics in approximately 35 fields of varying sizes (Figure 1).