gebhart/patrepeval huggingface dataset:
In situ tissue engineering with synthetic self-assembling peptide nanofiber scaffolds, PuraMatrix, for mucosal regeneration in the rat middle-ear (2013)

Middle-ear mucosa maintains middle-ear pressure. However, the majority of surgical cases exhibit inadequate middle-ear mucosal regeneration, and mucosal transplantation is necessary in such cases. The aim of the present study was to assess the feasibility of transplantation of isolated mucosal cells encapsulated within synthetic self-assembling peptide nanofiber scaffolds using PuraMatrix, which has been successfully used as scaffolding in tissue engineering, for the repair of damaged middle-ear. Middle-ear bullae with mucosa were removed from Sprague Dawley (SD) transgenic rats, transfected with enhanced green fluorescent protein (EGFP) transgene and excised into small pieces, then cultured up to the third passage. After surgical elimination of middle-ear mucosa in SD recipient rats, donor cells were encapsulated within PuraMatrix and transplanted into these immunosuppressed rats. Primary cultured cells were positive for pancytokeratin but not for vimentin, and retained the character of middle-ear epithelial cells. A high proportion of EGFP-expressing cells were found in the recipient middle-ear after transplantation with PuraMatrix, but not without PuraMatrix. These cells retained normal morphology and function, as confirmed by histological examination, immunohistochemistry, and electron microscopy, and multiplied to form new epithelial and subepithelial layers together with basement membrane. The present study demonstrated the feasibility of transplantation of cultured middle-ear mucosal epithelial cells encapsulated within PuraMatrix for regeneration of surgically eliminated mucosa of the middle-ear in SD rats.
Influence of Indenyl Ligand Substitution Pattern on Metallocene-Catalyzed Ethene Copolymerization with 1-Octene (1997)

The influence of silylene-bridged bis(indenyl) ligand substitution, especially benzannelation and 2-methyl substitution, on methylaluminoxane-activated metallocene-catalyzed ethene/1-octene copolymerization in toluene at 40 °C was investigated. 2-Methyl substitution gave significantly higher molecular masses at the expense of catalyst activity, whereas benzannelation promoted 1-octene incorporation and randomness of the resulting poly(ethene-co-1-octene) copolymers. Force field calculations based on steric arguments were used to explain experimental copolymerization results. Activation energy differences between ethene and 1-octene insertion accounted for improved 1-octene incorporation in the case of benzannelated metallocenes. According to 13C-NMR microstructure analysis, copolymerization followed first-order Markov statistics.
Solventogenesis in <i>Clostridium acetobutylicum</i> fermentations related to carboxylic acid and proton concentrations (1988)

The mechanism primarily implicated in the solventogenesis process in batch fermentations of Clostridium acetobutylicum is examined in considerable detail. A variety of fermentations with or without pH control in the pH range of 3.7-6 have been carried out in order to examine which of a host of suspect parameters correlate with the initiation of solventogenesis. The parameters that did not correlate are the external (pH(0)) and intracellular (pH(i)) pH, and DeltapH, and the external or intracellular butyrate and acetate concentrations. Undissociated butyric acid (UBA) correlated well with the initiation of solventogenesis. A linear relationship between UBA and butanol concentrations was found at the onset of solventogenesis in all fermentations examined. The intercept of this linear relationship was 6-13mM UBA for the pH(0) range of 3.7-5 and approximately zero for pH(0) at or above 6. The required minimal UBA was interpreted as a dependency of the solventogenesis process on both H(+) and butyrate concentrations. Undissociated acetic acid was found not to correlate with the initiation of solventogenesis. Addition of acetoacetate (AA) and propionate enhanced the effect of UBA on the solventogenesis process. The action of a nonmetabolizable (FCCP) and a metabolizable (AA) uncoupler on the DeltapH, pH(0), pH(i), and solventogenesis were also studied in order to gain further understanding of the solventogenesis mechanism.
Circulating clonal lymphocytes in myeloma constitute a minor subpopulation of B cells [see comments] (1996)

The mononuclear cells in the blood of myeloma patients have been reported to contain a high proportion of phenotypically abnormal myeloma B lymphocytes. These cells have been proposed to constitute the drug-resistant proliferative myeloma cell compartment. To determine the extent of B lymphocyte involvement, the proportion of clonotypic cells among the CD19-expressing cells from myeloma patients was estimated by quantitative polymerase chain reaction analysis of the third complementarity determining region (CDR3). The results indicate that the B lymphocytes constitute, on average, 6% of blood mononuclear cells, and that only a minor fraction of these are clonally related to the myeloma cells. While the small number of circulating clonal cells is not incompatible with their proposed role as a reservoir of proliferating myeloma progenitors, the majority of the B cells appear not to be clonally related to the myeloma cells.
Feature Vector Selection and Use With Hidden Markov Models to Identify Frequency-Modulated Bioacoustic Signals Amidst Noise (2008)

This paper describes an effective process for automated detection and classification of frequency-modulated sounds from birds, crickets, and frogs that have a narrow short-time frequency bandwidth. An algorithm is provided for extracting these signals from background noise using a frequency band threshold filter on spectrograms. Feature vectors are introduced and demonstrated to accurately model the resultant bioacoustic signals with hidden Markov models. Additionally, sequences of sounds are successfully modeled with composite hidden Markov models, allowing for a wider range of automated species recognition.
Security and Privacy Protection in Visual Sensor Networks (2014)

Visual sensor networks (VSNs) are receiving a lot of attention in research, and at the same time, commercial applications are starting to emerge. VSN devices come with image sensors, adequate processing power, and memory. They use wireless communication interfaces to collaborate and jointly solve tasks such as tracking persons within the network. VSNs are expected to replace not only many traditional, closed-circuit surveillance systems but also to enable emerging applications in scenarios such as elderly care, home monitoring, or entertainment. In all of these applications, VSNs monitor a potentially large group of people and record sensitive image data that might contain identities of persons, their behavior, interaction patterns, or personal preferences. These intimate details can be easily abused, for example, to derive personal profiles. The highly sensitive nature of images makes security and privacy in VSNs even more important than in most other sensor and data networks. However, the direct use of security techniques developed for related domains might be misleading due to the different requirements and design challenges. This is especially true for aspects such as data confidentiality and privacy protection against insiders, generating awareness among monitored people, and giving trustworthy feedback about recorded personal data—all of these aspects go beyond what is typically required in other applications. In this survey, we present an overview of the characteristics of VSN applications, the involved security threats and attack scenarios, and the major security challenges. A central contribution of this survey is our classification of VSN security aspects into data-centric, node-centric, network-centric, and user-centric security. We identify and discuss the individual security requirements and present a profound overview of related work for each class. We then discuss privacy protection techniques and identify recent trends in VSN security and privacy. A discussion of open research issues concludes this survey.
[Effect of new quaternary imino compounds against selected bacterial and fungal strains. 11. Synthesis of 1-methyl- and 1-ethyl-3-(n-alkoxymethyl)imidazolium chlorides]. (1985)

Syntheses and antibacterial activity of the imidazolium compounds are described. Syntheses of the imidazolium chlorides were performed by reaction of 1-alkylimidazole with chloromethylalkyl ether. Antibacterial properties of obtained compounds was tested on 13 strains of bacteria and fungi. Chlorides with n-dodecaoxymethyl radical indicated the best antibacterial activity.
Industry standards for recognition of marginal wood defects (1990)

Resultats d'une etude portant sur 46 compagnies americaines productrices de bois en vue de definir ce qui constitue un defaut marginal dans la pratique industrielle et dans quelle mesure on peut utiliser des normes ecrites ou visuelles
Cytoprotective effects of quercetin and its sugar-containing natural congeners in cultured HEK293 cells injured by anoxia/hypoglycemia and the structure-effect relationship thereto (2008)

Objective To comparatively study anti-free radical and cytoprotective effects of quercetin(Q)and its monoglucoside isoquercetin(I),diglucoside rutin(R),which differs only in glycosyl-substitution at C-3 position of the molecules,using anoxia/hypoglycemia-induced cell injury model and thereby to explore the structure-effect relationship thereto.Methods The cell injury model was established by HEK293 cells cultured in vitro with Na2S2O3 plus sugar-free Earle’s fluid as incubation medium;Cell survival rate(CSR),total antioxidant capacity(TAC),SOD and LDH levels were determined;The effect intensity of the 3 flavonoids were compared by means of IC50,the concentration required to achieve 50% inhibition of the changes in the above indices in injured cells.Results Q,I and R all concentration-dependently elevated CSR,TAC and SOD,and reduced LDH level;the all of IC50s for the above indices were ranked in order of IC50,Q I>R.Conclusions The 3 structurally similar flavoloids all have significant and concentration-dependent anti-free radical and cyto-protective effects with the intensity being in order of aglycone>monoglucoside>diglucoside;the substitution of-OH by sugar group at C-3 position of flavoloids and increase in the sugar-substituent number are associated with the effect intensity reduced;namely,the intensity of these effects of flavonoids is negatively related the substutution by sugar group at C-3 position.
The Genome Sequences of Cellulomonas fimi and “Cellvibrio gilvus” Reveal the Cellulolytic Strategies of Two Facultative Anaerobes, Transfer of “Cellvibrio gilvus” to the Genus Cellulomonas, and Proposal of Cellulomonas gilvus sp. nov (2013)

Actinobacteria in the genus Cellulomonas are the only known and reported cellulolytic facultative anaerobes. To better understand the cellulolytic strategy employed by these bacteria, we sequenced the genome of the Cellulomonas fimi ATCC 484(T). For comparative purposes, we also sequenced the genome of the aerobic cellulolytic "Cellvibrio gilvus" ATCC 13127(T). An initial analysis of these genomes using phylogenetic and whole-genome comparison revealed that "Cellvibrio gilvus" belongs to the genus Cellulomonas. We thus propose to assign "Cellvibrio gilvus" to the genus Cellulomonas. A comparative genomics analysis between these two Cellulomonas genome sequences and the recently completed genome for Cellulomonas flavigena ATCC 482(T) showed that these cellulomonads do not encode cellulosomes but appear to degrade cellulose by secreting multi-domain glycoside hydrolases. Despite the minimal number of carbohydrate-active enzymes encoded by these genomes, as compared to other known cellulolytic organisms, these bacteria were found to be proficient at degrading and utilizing a diverse set of carbohydrates, including crystalline cellulose. Moreover, they also encode for proteins required for the fermentation of hexose and xylose sugars into products such as ethanol. Finally, we found relatively few significant differences between the predicted carbohydrate-active enzymes encoded by these Cellulomonas genomes, in contrast to previous studies reporting differences in physiological approaches for carbohydrate degradation. Our sequencing and analysis of these genomes sheds light onto the mechanism through which these facultative anaerobes degrade cellulose, suggesting that the sequenced cellulomonads use secreted, multidomain enzymes to degrade cellulose in a way that is distinct from known anaerobic cellulolytic strategies.
Clustering and classification of large document bases in a parallel environment (1997)

Development of cluster-based search systems has been hampered by prohibitive times involved in clustering large document sets. Once completed, maintaining cluster organizations is difficult in dynamic file environments. We propose the use of parallel computing systems to overcome the computationally intense clustering process. Two operations are examined. The first is clustering a document set and the second is classifying the document set. A subset of the TIPSTER corpus, specifically, articles from the Wall Street Journal, is used. Document set classification was performed without the large storage requirement (potentially as high as 522M) for ancillary data matrices. In all cases, the time performance of the parallel system was an improvement over sequential system times, and produced the same clustering and classification scheme. Some results show near linear speed up in higher threshold clustering applications. © 1997 John Wiley & Sons, Inc.
Characterization of the electrically evoked release of substance P from dorsal root ganglion neurons: methods and dihydropyridine sensitivity (1988)

The mechanism by which dihydropyridines (DHPs) modulate the electrically evoked or KCI-induced release of substance P (SP) from embryonic chick dorsal root ganglion (DRG) neurons was investigated in the present study. The release of SP, as measured by radioimmunoassay (RIA), was characterized in terms of its dependence on extracellular calcium ion, its stimulus-response relationship, its sensitivity to the calcium-channel blocker omega conus toxin (omega-CgTx), and its modulation by the DHPs Bay K 8644 and nifedipine. Here it is reported that omega-CgTx (1 microM) blocked the electrically evoked release of SP. In contrast, the calcium-channel agonist Bay K 8644 (5 microM) facilitated the release of SP (by 45%), whereas the calcium-channel antagonist nifedipine (5 microM) was without effect. When the release of SP was triggered by depolarization of cultures with 60 mM KCI, the actions of the DHPs became much more pronounced. Under these conditions, Bay K 8644 facilitated (by 115%), whereas nifedipine inhibited (by 58%), peptide secretion. Voltage-clamp analysis of DRG cell calcium currents demonstrated that these actions of omega-CgTx, Bay K 8644, and nifedipine are explicable in terms of their effects on the slowly inactivating (L-type) calcium current. On the basis of these findings, it is suggested that the SP release mechanism exhibits DHP sensitivity due to the involvement of L-type calcium channels in the neurosecretory process. This model predicts that the voltage and time-dependent antagonist actions of nifedipine are sufficient to explain its failure to inhibit the electrically evoked release of SP.
Determination of oxprenolol by electrogenerated chemiluminescence (1995)

This work describes a novel method for the selective determination of oxprenolol, a beta-adrenergic antagonist, using flow injection analysis with electrogenerated chemiluminescence (ECL). The method is based on the ECL reaction of tris-(2,2′-bipyridine)ruthenium(II)[Ru(bpy)32+] with the secondary amino group on oxprenolol. The factors affecting the determination were investigated and a calibration was obtained with 6.67 s pulses at +1.3 V, using 1.5 mmol l–1 Ru(bpy)32+ in 0.05 mol l–1 phosphate buffer at pH 5.5, and a flow rate of 2 ml min–1. A linear calibration plot was obtained for signal (in mV)versus oxprenolol concentration (in mmol l–1) over the range 0.0001–0.04 mmol l–1(30–12 000 ng ml–1), with %sr less than 5% for 5 replicates. The 3δ limit of detection was calculated as 35 nmol l–1(11 ng ml–1).
Frequency-modulated single-mode laser (1968)

Three frequency-modulated single-mode lasers employing long multicavity resonators are presented. The f.m. is achieved by simultaneous changes of the length of the additional cavities in such a way that resonance conditions are preserved, and the resonator Q factor remains constant. The linear electro-optic Pockels effect in KDP crystals is used to change the optical length of the additional cavities.
Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition (2004)

Through a positional cloning approach, the thioredoxin-interacting protein gene (Txnip) was recently identified as causal for a form of combined hyperlipidemia in mice (Bodnar, J. S., A. Chatterjee, L. W. Castellani, D. A. Ross, J. Ohmen, J. Cavalcoli, C. Wu, K. M. Dains, J. Catanese, M. Chu, S. S. Sheth, K. Charugundla, P. Demant, D. B. West, P. de Jong, and A. J. Lusis. 2002. Positional cloning of the combined hyperlipidemia gene Hyplip1. Nat. Genet. 30: 110-116). We now show that Txnip-deficient mice in the fed state exhibit a metabolic profile similar to fasted mice, including increased levels of plasma ketone bodies and free fatty acids, decreased glucose, and increased hepatic expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha, phosphoenolpyruvate carboxykinase, glucose-6-phosphatase, and acyl-CoA oxidase. Dramatic differences in the expression of key metabolic enzymes were also observed in other tissues, and the fat-to-muscle ratio of Txnip-deficient mice was increased by approximately 40%. We demonstrate an effect of Txnip on the redox status, as the Txnip-deficient mice in the fed state had a significant increase in the ratio of NADH to NAD(+). Surprisingly, we observed that Txnip-deficient mice and wild-type mice had similar levels of thioredoxin activity, suggesting that the effects of Txnip deficiency may be mediated in part by other interactions. These results indicate a role for Txnip in the metabolic response to feeding and the maintenance of the redox status.
Some nematodes from Victorian and Western Australian marsupials (1939)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Computationally inexpensive enhanced growing neural gas algorithm for real-time adaptive neural spike clustering (2019)

The EGNG algorithm provides a viable solution to classification of neural spikes in real-time and can be implemented with limited computational resources as a front-end spike clustering unit for future tethered-free and miniaturized closed-loop neural feedback systems.
Equivalence of nonlinear shift-registers (1964)

Two forms of nonlinear-feedback shift-registers are considered. In the Type-I register, the feedback output is added to the shift-register contents at an arbitrary number of stages. In the type-II register, the feedback is input to the first stage only. It is shown that for every Type-I register there is an equivalent Type-II register in the sense that the autonomous state diagrams differ only by a labelling of the states. Moreover, the mapping between equivalent states can always be chosen to be a linear transformation. This theorem is a well-known result in the theory of linear-feedback shift-registers and is thus seen to apply unchanged to the nonlinear case.
Second homes planning, policy and governance (2014)

The topic of second homes has been of major interest in regional, rural and tourism planning and policy since the 1970s. More recently the lens of governance has also begun to be applied as a lens to the topic of mobility, including second homes. This paper provides a review of the literature on second homes, policy and governance and highlights major themes and issues including that of housing policy, sustainability, political representation and the environment. The paper suggests that research in the governance of second homes can help shed further light on problems of understanding and governing mobility and multiple dwellings in contemporary neoliberal globalisation. It highlights that that governance, policy and regulatory structures are much better geared to the stationery and the immobile than they are to the movement of people (and capital) between jurisdictions, as well as to mobile homes themselves.
Register locking in an asynchronous microprocessor (2003)

A high-performance register bank is a central component of a RISC processor. A novel register bank design has been developed, as an integral part of a self-timed implementation of a commercial RISC microprocessor, to address the problem of register interlocking in an asynchronous micropipelined execution unit. The problem in an asynchronous design is to maintain coherent register operation while allowing concurrent read and write accesses with arbitrary timing. The solution presented here includes a novel arbiter-free locking mechanism which enables efficient read operations in the presence of multiple pending write operations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Preconditioning in Immature Rabbit Hearts (1999)

Immature hearts normoxic from birth can be preconditioned, whereas immature hearts hypoxic from birth cannot. Preconditioning in normoxic immature hearts is associated with activation of the KATP channel.
Influence of neutron irradiation on the magnetic properties of FeNiCrMoSiB amorphous alloys (1988)

The effects of neutron irradiation on the magnetic properties of FeNiCrMoSiB amorphous alloys are investigated by means of the temperature dependence of the spontaneous magnetization and the low field ac susceptibility. It is found that the irradiation leads to a decrease of the values of Curie temperature and the spin-wave stiffness constant. These findings are discussed in terms of the possible irradiation induced effects of structural and chemical changes in the amorphous alloys investigated. [Russian Text Ignored].
Cooperative spectrum sensing using random matrix theory (2008)

In this paper, using tools from asymptotic random matrix theory, a new cooperative scheme for frequency band sensing is introduced for both AWGN and fading channels. Unlike previous works in the field, the new scheme does not require the knowledge of the noise statistics or its variance and is related to the behavior of the largest and smallest eigenvalue of random matrices. Remarkably, simulations show that the asymptotic claims hold even for a small number of observations (which makes it convenient for time-varying topologies), outperforming classical energy detection techniques.
All-fiber compound ring resonator with a ring filter (1994)

The new all-fiber compound ring resonator has two rings: a primary one that serves as a resonator, and a secondary one that serves as a filter. The main contribution of this resonator is to increase the free spectral range by choosing the fiber lengths in the compound ring cavity. This resonator with a large free spectral range can be readily used as a doped fiber laser. The optimum resonant conditions of the resonator are discussed by using an equivalent model and by the transfer matrix method. The frequency responses of the output and of the circulating intensities are given. Mode suppression by the vernier effect is demonstrated. Comparison with a fiber Fox-Smith resonator is also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>