gebhart/patrepeval huggingface dataset:
Effect of liposomal confinement on photothermal and photo-oximetric fluorescence lifetimes of photosensitizers with varying hydrophilicity (2008)

The time-resolved fluorescence of photosensitizers (PSs) of varying hydrophobicities, di-and tetrasulfonated Al phthalocyanines (Al-2 and Al-4), and Photochlor (HPPH), was investigated in liposomes used as cell-mimetic models. Using frequency-and time-domain apparatus, the fluorescence lifetime, tau(fluo), was compared for PSs free in aqueous solution and in a liposome-associated state at varied temperatures (25 to 78 degrees C) and oxygen concentrations (0-190 microM). The analysis of tau(fluo) revealed different decay behaviors for the free-solution and liposome-confined PSs, most significantly for the lipophilic HPPH. Hydrophilic PS drugs (Al-4, Al-2) were less affected by the liposomal confinement, depending on the relative hydrophilicity of the compound and the consequent localization in liposomes. Changes in the emission decay due to confinement were detected as differences in the lifetime between the bulk solution and the liposome-localized PS in response to heating and deoxygenation. Specifically, hydrophilic Al-4 produced an identical lifetime trend as a function of temperature both in solu and in a liposome-confined state. Hydrophobic HPPH exhibited a fundamental transformation in its fluorescence decay kinetics, transitioning from a multiexponential (in free solution) to single-exponential (in liposome) decay. Deoxygenation resulted in a ubiquitous tau(fluo) increase for all PSs in free solution, while the opposite, a tau(fluo) decrease, occurred in all liposomal PSs.
Extensions of the hydrazone and Beckmann rearrangements (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExtensions of the hydrazone and Beckmann rearrangementsKenneth Nolon Carter and James E. Hulse IIICite this: J. Org. Chem. 1982, 47, 11, 2208–2210Publication Date (Print):May 1, 1982Publication History Published online1 May 2002Published inissue 1 May 1982https://pubs.acs.org/doi/10.1021/jo00132a050https://doi.org/10.1021/jo00132a050research-articleACS PublicationsRequest reuse permissionsArticle Views459Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
FABRICATION OF SILVER-DOPED ZINC OXIDE THIN FILMS THROUGH OPTIMIZED SOL-GEL DEPOSITION AND NANOPARTICLE WETTING PROCESS (2018)

Zinc Oxide (ZnO) has been of significant interest as a Transparent Conductive Oxide (TCO) given its sizable direct band-gap, and as a potential substitute for Indium-Tin Oxide for use in opto-electronic and piezo-electric devices, due to its comparatively abundant and nontoxic precursor materials. Sol-gel processing is an easy, low-energy method for fabricating ZnO thin films, and there has been increasing interest in doping the compound such to give it p-type semiconductive character.\nThis thesis thoroughly investigates sol-gel processing of ZnO thin solid films, with focus on wet-chemistry (sol-gel) methods of doping the material with silver (both as elemental ions and nanoparticles,) in the interest of achieving p-type doped ZnO. From dozens of similar but varying documented procedures, optimal processing methods and parameters for experimentation involving solutions-based doping were investigated and codified into a repeatable standard operating procedure (SOP), confirmed by X-Ray Diffraction results showing preferential (002)-peak, c-axis crystalline orientation. Heretofore unexplored study of the use of organic solvents as wetting agents and introduction of silver nanoparticles in layering processes within the sol-gel processing framework are shown to further improve c-axis orientation. A newly-adapted, quantified method of XRD preferential orientation analysis is implemented alongside UV-Visual bandgap analysis and SEM/AFM microscopy methods to further confirm improved crystallinity and reduced-diameter nanoscale c-axis oriented crystallites.\nThese experiments and characterizations are analyzed in the context of structure and properties leading to material performance, with results documented in detailed appendices.
Generation of a germ cell‐specific mouse transgenic Cre line, <i>Vasa‐Cre</i> (2007)

Cell type-specific genetic modification using the Cre/loxP system is a powerful tool for genetic analysis of distinct cell lineages. Because of the exquisite specificity of Vasa expression (confined to the germ cell lineage in invertebrate and vertebrate species), we hypothesized that a Vasa promoter-driven transgenic Cre line would prove useful for the germ cell lineage-specific inactivation of genes. Here we describe a transgenic mouse line, Vasa-Cre, where Cre is efficiently and specifically expressed in germ cells. Northern analysis showed that transgene expression was confined to the gonads. Cre-mediated recombination with the Rosa26-lacZ reporter was observed beginning at approximately e15, and was >95% efficient in male and female germ cells by birth. Although there was a potent maternal effect with some animals showing more widespread recombination, there was no ectopic activity in most adults. This Vasa-Cre transgenic line should thus prove useful for genetic analysis of diverse aspects of gametogenesis and as a general deletor line.
Effect of solvent and cation on the reaction of organometallic derivatives of indole with methyl iodide (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of solvent and cation on the reaction of organometallic derivatives of indole with methyl iodideManfred G. Reinecke, John F. Sebastian, Harry W. Johnson Jr., and Chongsuh PyunCite this: J. Org. Chem. 1972, 37, 20, 3066–3068Publication Date (Print):October 1, 1972Publication History Published online1 May 2002Published inissue 1 October 1972https://pubs.acs.org/doi/10.1021/jo00985a005https://doi.org/10.1021/jo00985a005research-articleACS PublicationsRequest reuse permissionsArticle Views646Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage (2010)

Chromatin structure is known to be a barrier to DNA repair and a large number of studies have now identified various factors that modify histones and remodel nucleosomes to facilitate repair. In response to ultraviolet (UV) radiation several histones are acetylated and this enhances the repair of DNA photoproducts by the nucleotide excision repair (NER) pathway. However, the molecular mechanism by which UV radiation induces histone acetylation to allow for efficient NER is not completely understood. We recently discovered that the E2F1 transcription factor accumulates at sites of UV-induced DNA damage and directly stimulates NER through a non-transcriptional mechanism. Here we demonstrate that E2F1 associates with the GCN5 acetyltransferase in response to UV radiation and recruits GCN5 to sites of damage. UV radiation induces the acetylation of histone H3 lysine 9 (H3K9) and this requires both GCN5 and E2F1. Moreover, as previously observed for E2F1, knock down of GCN5 results in impaired recruitment of NER factors to sites of damage and inefficient DNA repair. These findings demonstrate a direct role for GCN5 and E2F1 in NER involving H3K9 acetylation and increased accessibility to the NER machinery.
Nickel-Catalyzed Cross-Coupling of Aryl Chlorides with Aryl Grignard Reagents (2000)

The ambient temperature Grignard cross-coupling of aryl chlorides with aryl magnesium halides [Eq. (1)] is made possible for the first time by nickel catalysts containing bulky N-heterocyclic carbene or bulky phosphane ligands. A 19F NMR spectroscopic screening assay with fluorinated aryl chlorides was employed to achieve a rapid identification and optimization of high-performance catalysts. acac = acetylacetonate. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2000/z14437_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
: <i>Men and Masks: A Study of Molière.</i> (1964)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
An Improved Separator for the Developmental Stages, Sexes, and Species of Mosquitoes (Diptera: Culicidae) (1980)

A mechanical device, modified from a previous design, is described for separating the developmental stages, sexes, and species of mosquitoes.
The Rearrangement of α,β-Epoxy Ketones. VIII. Effect of Substituents on the Rate of Rearrangement (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Rearrangement of α,β-Epoxy Ketones. VIII. Effect of Substituents on the Rate of RearrangementHerbert O. House and George D. RyersonCite this: J. Am. Chem. Soc. 1961, 83, 4, 979–983Publication Date (Print):February 1, 1961Publication History Published online1 May 2002Published inissue 1 February 1961https://pubs.acs.org/doi/10.1021/ja01465a052https://doi.org/10.1021/ja01465a052research-articleACS PublicationsRequest reuse permissionsArticle Views486Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterization of an Autoinhibitory Domain in Human Mitogen-activated Protein Kinase-activated Protein Kinase 2 (1995)

Mitogen-activated protein (MAP) kinase-activated protein kinase 2, a Ser/Thr kinase, is phosphorylated and activated by MAP kinase. Sequence analysis of a clone isolated from the human HL-60 cell line revealed a 370-amino acid protein with a proline-rich N terminus, a highly conserved catalytic domain, and a C-terminal region containing a MAP kinase phosphorylation site. To better understand how the kinase is regulated, mutation analysis was used to map the functional domain(s). The wild type recombinant kinase had a low basal activity as detected by phosphorylation of a substrate peptide derived from the N terminus of glycogen synthase. Deletion of the proline-rich N terminus showed little effect on the basal activity. Deletion of the C terminus resulted in a marked increase in catalytic activity either with or without the pretreatment of the kinase by MAP kinase. Further analysis indicated that amino acid residues 339-353 in the C-terminal region were acting as an autoinhibitory domain. A synthetic peptide (RVLKEDKERWEDVK-amide) derived from this autoinhibitory domain inhibited the kinase activity in a concentration-dependent manner. These results suggest a regulatory model for the kinase.
Transformation of differentiated rat hepatocytes with adenovirus and adenovirus DNA (1987)

Primary cultures of hepatocytes isolated by collagenase perfusion of adult rats were transformed by infection with adenovirus type 5 or transfection with adenovirus DNA. Total virion DNA or recombinant plasmid DNA containing the adenovirus E1A and E1B genes transformed hepatocytes at comparable frequencies. No foci of replicating hepatocytes were detected after transfection with a plasmid containing the E1A gene alone. The frequency of transformation by the adenovirus E1A and E1B genes was dependent on the composition of the culture medium. Transformation occurred at a low frequency when the transfected hepatocytes were maintained in a chemically defined medium (CDM), but the frequency was enhanced 8- to 10-fold when the cells were maintained in (i) serum-supplemented medium or (ii) CDM supplemented with epidermal growth factor. Cell lines derived from the adenovirus-transformed colonies of hepatocytes expressed adenovirus E1A and E1B RNAs. When hepatocytes were maintained in CDM supplemented with dimethyl sulfoxide and transfected with plasmids containing the E1A and E1B genes, it was possible to derive cell lines that retained the ability to express several liver-specific genes, including albumin, transferrin, hemopexin, and the third component of complement. The amount of albumin secreted per cell varied from 1 to 5 pg per cell per 24 h, and in one cell line it was below detectable levels by passage 9. Adenovirus-transformed hepatocytes were not tumorigenic when inoculated subcutaneously into neonatal syngeneic rats. We conclude that the adenovirus E1A and E1B genes are capable of transforming adult rat hepatocytes, a differentiated epithelial cell type.
CUDA-based acceleration of the JPEG decoder (2013)

In this paper, an accelerated JPEG (Joint Photographic Experts Group) decoder was efficiently implemented on the GPU (Graphic Processing Unit) using the CUDA (Computer Unified Device Architecture) technology and it is capable for high definition images decoding. The CUDA technology can assist the GPU to work for the CPU for large computation. In this paper, the IDCT(Inverse Discrete Cosine Transform) model which has consumed about 75% the total time in the JPEG decoder is worked in the GPU by the CUDA, and other models of the JPEG decoder are designed in the CPU. At the same time, we use the asynchronous parallel execution between the CPU and the GPU to improve the JPEG decoder acceleration rate. In the experiment, the JPEG decoder based on the CUDA performs decompression of 3240 × 2160 pixels images, the implementation of the CUDA-based IDCT can be more than 49 times faster than the implementation on the CPU and the total processing time of the whole JPEG decoder can save about 50% time than the CPU.
Performance evaluation of solar photovoltaic arrays including shadow effects using neural network (2009)

This paper proposes a neural network based approach to estimating the maximum possible output power of a solar photovoltaic array under the non-uniform shadow conditions at a given geographic location. Taking the solar irradiation levels, the ambient temperature, and the sun's position angles as inputs, a multilayer feed-forward neural network estimates the output power of the solar photovoltaic array. Training data for the neural network is generated by conducting a series of experiments on a shaded solar panel at different hours of a day for several days. After training the neural network, its accuracy and generalization properties are verified on test data. It is found that the neural network, which is an approximation of the actual shading function, is able to estimate the maximum possible output power of the solar PV arrays accurately. Further, the network is able to estimate the maximum output power for field data and gives rise to the possibility that the proposed approach can be used for making decision regarding the installation of solar PV arrays in the field.
STRUCTURE AND MATERIALS ASPECTS OF THE PRIME FLIGHT TEST VEHICLE (1966)

Abstract : The structure and thermal protection system being developed as part of the START Program is described. The program is concerned with the design and flight test of a small maneuverable lifting reentry vehicle of the SV-5 configuration (hypersonic lift-to-drag ratio of approximately 1.3) with an ablative heat shield. Reentry conditions will simulate those encountered in return from low earth orbit. This program is expected to produce technology that could be applicable to manned, maneuverable reentry. A description of the thermal/structural configuration, load paths, materials used, discontinuities and attachment to the launch vehicle is given. The influence of primary structural material on heat shield integrity and vehicle weight is discussed. Loading conditions and vehicle thermal/structural design criteria are described. The reentry environment of the vehicle is compared with related systems. Heating rates, total heats, shear loads, and pressures are shown, and thermochemical and thermophysical properties of various heat shield materials are discussed. Materials tests and data are compared with many applicable heat shield materials.
<i>iFind</i> —a system for semantics and feature based image retrieval over Internet (2000)

iFind© (v 1.0) is a web based image retrieval system developed at Microsoft Research China. It provides the functionalities of keyword based image search, query by image example, category based image browsing, relevance feedback, and semi-automatic image annotation. The key technology in the system is the integrated semantics and feature based image retrieval and relevance feedback approach, which will be presented in our paper in the ACM Multimedia 2000 Proceedings [1]. When the user provides feedback images, the system can refine the retrieval result based on the user's feedback. In the meantime, the system updates the annotation of feedback images by increasing the linkage to the positive examples' annotation and decreasing the linkage to the negative examples' annotation. The updated annotation can further help to improve image retrieval results of the system in later use.
Synthesis and Single-Crystal Refinement of Ba <sub>2</sub> Y <sub>2</sub> CuPtO <sub>8</sub> (1987)

Ba2Y2CuPtO8 is orthorhombic (space group Pnma) with a = 13.207(2), b = 5.680(2) and c = 10.321(2) Å. The structure was refined from 2654 x-ray independent reflections to R = 0.050 (Rw = 0.059). The lattice is built up from double chains of corner-sharing platinum octahedra and copper pyramids running along the b-axis. Yttrium and barium ions ensure the cohesion of the structure. The crystal chemistry of Ba2Y2CuPtO8 is discussed and compared to the structure of KPbCr2F9.
Combining Graph Laplacians for Semi--Supervised Learning (2005)

A foundational problem in semi-supervised learning is the construction of a graph underlying the data. We propose to use a method which optimally combines a number of differently constructed graphs. For each of these graphs we associate a basic graph kernel. We then compute an optimal combined kernel. This kernel solves an extended regularization problem which requires a joint minimization over both the data and the set of graph kernels. We present encouraging results on different OCR tasks where the optimal combined kernel is computed from graphs constructed with a variety of distances functions and the 'κ' in nearest neighbors.
CROSS-OVER TRIALS WITH CENSORED DATA (1996)

Cross-over trials assign two or more treatments sequentially to the same subject; groups of subjects receive different treatment sequences. Both parametric and non-parametric methods of inference are available for cross-over trials with complete data. In this paper we develop methods for estimation and testing in cross-over trials with censored data, based partly on methods used for complete data. Our estimator is consistent for the true effects. Simulation results show that both of our proposed tests have approximately nominal size. We compare our procedures to a method for cross-over designs based on Cox regression proposed by France, Lewis and Kay. We demonstrate that our method of estimation is superior to the Cox-based method, which has considerable bias. Both of the tests presented here have more power than the Cox-based tests in all of the situations we investigated. The estimation and test procedures apply to other designs, such as parallel trials and repeated measures designs.
Hydrogen-Storage Materials Based on Imidazolium Ionic Liquids (2007)

Simple 1-alkyl(aryl)-3-methylimidazolium N-bis(trifluoromethanesulfonyl)imidate salts that possess very low vapor pressure, high density, and thermal stability and are not inflammable can add reversibly 6−12 hydrogen atoms in the presence of classical Pd/C or Ir0 nanoparticle catalysts and can be used as alternative materials for on-board hydrogen-storage devices. These salts can hold up to 30 g L-1 of hydrogen at atmospheric pressure, which is twice that compressed hydrogen gas can attain at 350 atm.