gebhart/patrepeval huggingface dataset:
Activity of ABT-773 against <i>Mycobacterium avium</i> Complex in the Beige Mouse Model (2000)

ABT-773, a new ketolide antimicrobial agent, was evaluated in comparison to clarithromycin (CLA) in vitro against Mycobacterium avium complex (MAC) and in a beige mouse model of disseminated MAC infection. The MICs at which 50 and 90% of the isolates tested were inhibited were 2 and 4 microg/ml, respectively, for CLA and 8 and 16 microg/ml, respectively, for ABT-773. Eight CLA-resistant isolates were found to be resistant to ABT-773 (MICs > 64 microg/ml). In the in vivo study mice were treated with ABT-773 (50, 100, and 200 mg/kg of body weight) or CLA (200 mg/kg). Both ABT-773 (100 and 200 mg/kg) and CLA significantly decreased the viable cell counts in spleens and lungs. ABT-773 (200 mg/kg) and CLA had similar activities in lungs, but the former was more active in spleens.
Regiospecificity. Useful terminology in addition and elimination reactions (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegiospecificity. Useful terminology in addition and elimination reactionsAlfred HassnerCite this: J. Org. Chem. 1968, 33, 7, 2684–2686Publication Date (Print):July 1, 1968Publication History Published online1 May 2002Published inissue 1 July 1968https://pubs.acs.org/doi/10.1021/jo01271a015https://doi.org/10.1021/jo01271a015research-articleACS PublicationsRequest reuse permissionsArticle Views532Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Coronary artery tree tracking with robust junction detection in 3D CT Angiography (2011)

Computed Tomography Angiography (CTA) of the heart is a non-invasive procedure to rule out coronary artery disease or measure its extent and plan treatments and interventions. The need for coronary tree tracking methods that require minimum human interaction and produce accurate and robust measurements is therefore of great clinical importance. In this work we present a probabilistic coronary artery tree tracking method incorporating efficient statistical vessel junction detection. The method uses a single initial seed point at the top of the tree and recursively tracks every vessel branch based on a Sequential Monte Carlo framework. All junctions along the vessel tree are detected automatically. Performance of the proposed method is evaluated using the Rotterdam public coronary tracking evaluation framework that includes 24 cardiac CTA datasets. Our method yields accurate and robust tracking results with 92.7% average overlap with expert-defined centerlines.
Welding processes for plastics (1995)

To make large or complex thermoplastic parts, the most cost-effective method often involves molding two or more parts and joining them together. In such cases, the manufacturer has a variety of joining options, including adhesives, mechanical fastening, and fusion bonding or welding. Welding is particularly attractive for thermoplastic part assembly because joining times are often very short, enabling high throughput. Also, the various fusion processes typically produce strong joints, tolerate contaminated surfaces, and successfully join such difficult-to-bond substrates as polyolefins. They are also useful for joining polymers with low surface energies (such as polyethylene and polypropylene), which require complex surface activation treatments if they are to be adhesively joined.
The Importance of the Family in the Prevention of Mental Illness (1949)

IN the discussion of this subject I feel I need to first develop briefly why it seems to many persons that the family as a unit may become the most important dynamic entity with which to deal and plan in relation to the prevention of mental illness. In order to think in this way it seems appropriate to consider the soundness of the idea that the family is the medium wherein is produced the basis of the personality structure, and given its potentialities of growth. Historically this type of thinking about the family is relatively recent, and it comes to us from two sources: (1) the study of the individual within the family which got its impetus primarily from the psychoanalytical study of the individual, and which viewpoint was expounded in the now classic study in this field, that of Fliigel (1), published in the 1920's. (2) About this same time sociologists and anthropologists, as represented by Margaret Mead and Ernest Burgess, made the second contribution to the concept of dynamics and its relationship to personality in the family growth when they introduced the idea of the family as a unit of interacting personalities (2) rather than as a unit influenced and molded merely by such external factors as economic change, migration, and social cus-
Repo-Man Coordinates Chromosomal Reorganization with Nuclear Envelope Reassembly during Mitotic Exit (2011)

Repo-Man targets protein phosphatase 1 γ (PP1γ) to chromatin at anaphase onset and regulates chromosome structure during mitotic exit. Here, we show that a Repo-Man:PP1 complex forms in anaphase following dephosphorylation of Repo-Man. Upon activation, the complex localizes to chromosomes and causes the dephosphorylation of histone H3 (Thr3, Ser10, and Ser28). In anaphase, Repo-Man has both catalytic and structural functions that are mediated by two separate domains. A C-terminal domain localizes Repo-Man to bulk chromatin in early anaphase. There, it targets PP1 for the dephosphorylation of histone H3 and possibly other chromosomal substrates. An N-terminal domain localizes Repo-Man to the chromosome periphery later in anaphase. There, it is responsible for the recruitment of nuclear components such as Importin β and Nup153 in a PP1-independent manner. These observations identify Repo-Man as a key factor that coordinates chromatin remodeling and early events of nuclear envelope reformation during mitotic exit.
Shamed by a parent or by others: the role of attachment in shame memories relation to depression (2014)

"Recent research has shown that shame traumatic and central memories not only have an impact on feelings of shame in adulthood but also moderate the impact of shame on depression. Although the quality of attachment relationships may be important in structuring shame memories, the research on this topic has been scant. This paper explores the moderator effect of shame memories involving attachment figures vs. shame memories involving other people on the relationship between shame and depression. 230 participants from the general community population completed the Shame Experiences Interview, assessing shame experiences from childhood and adolescence, and a battery of self-report scales measuring: shame traumatic memory, centrality of shame memory, external shame, internal shame and depression. Results revealed that shame memories with attachment figures showed higher correlations with internal shame and depressive symptoms whereas shame memories involving others presented higher correlations with external shame. Moderator analyses showed that only shame traumatic memory and centrality of shame memory involving attachment figures moderated the impact of external and internal shame on depression. The current findings shed light on the importance of the quality of attachment relationships in the structuring of shame traumatic memories and on their impact on psychopathological symptoms, adding to recent neuroscience research and Gilbert’s approach on shame and compassion. Our results emphasize the relevance of addressing shame memories, mainly those that involve attachment figures, particularly when working with patients suffering from depressive symptoms and/or that find compassion difficult or scary."
Hardide: advanced nano-structured CVD coating (2007)

Hardide™ is a family of new low-temperature Chemical Vapour Deposition (CVD) Tungsten/Tungsten Carbide coatings. Coating consists of Tungsten Carbide nano-particles dispersed in metal Tungsten matrix, that give the material enhanced hardness of between 1100 Hv and 1800 Hv, and abrasion resistance up to 12 times better than Hard Chrome. Nano-structured materials show unique toughness, crack and impact-resistance. The coating is resistant to acids and aggressive media, can be produced on steel, including stainless steel and some tool steels, with coating thickness varied from 5 microns to 100 microns. Gas-phase CVD process allows coating internal surfaces and items of complex shape like dies, moulds, pump cylinders. Homogeneous pore-free structure facilitates finishing by honing, polishing, mirror finish can be achieved with suitable substrate. Use of Hardide with cutting tools for paper and plastics makes them self-sharpening. Application of Hardide increases life of tools and critical components and reduces down-time.
Improved Tracking of Multiple Humans with Trajectory Predcition and Occlusion Modeling (1998)

Abstract A combined 2D, 3D approach is presented that allows for robust tracking of moving bodies in a given environment as observed via a single, uncalibrated video camera. Tracking is robust even in the presence of occlusions. Low-level features are often insufficient for detection, segmentation, and tracking of non-rigid moving objects. Therefore, an improved mechanism is proposed that combines low-level (image processing) and mid-level (recursive trajectory estimation) information obtained during the tracking process. The resulting system can segment and maintain the tracking of moving objects before, during, and after occlusion. At each frame, the system also extracts a stabilized coordinate frame of the moving objects. This stabilized frame is used to resize and resample the moving blob so that it can be used as input to motion recognition modules. The approach enables robust tracking without constraining the system to know the shape of the objects being tracked beforehand; although, some assumptions are made about the characterstics of the shape of the objects, and how they evolve with time. Experiments in tracking moving people are described.
Symposium on VLSI circuits meets in June (2005)

The International Symposium on VLSI Circuits will be held on June 16–18th, 2005 at the Rihga Royal Hotel, Kyoto, Japan. The Symposium consists of three days of technical presentations and informal evening rump sessions on VLSI circuit design. Following tradition, the Symposium on VLSI Circuits will follow the Symposium on VLSI Technology at the same location.
Improving summaries by revising them (1999)

This paper describes a program which revises a draft text by aggregating together descriptions of discourse entities, in addition to deleting extraneous information. In contrast to knowledge-rich sentence aggregation approaches explored in the past, this approach exploits statistical parsing and robust coreference detection. In an evaluation involving revision of topic-related summaries using informativeness measures from the TIPSTER SUMMAC evaluation, the results show gains in informativeness without compromising readability.
Agrarian Policies (1966)

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsJack GrayJack Gray is a lecturer in Far Eastern history at the University of Glasgow. From 1953 to 1965 he lectured at Hong Kong University; in 1956 he visited the People's Republic of China. He is the author of articles on modern Chinese history and Chinese communist political organizations, and of a forthcoming book, Revolution and Consolidation in the Chinese Countryside, 1947–56, to be published in 1967.
Oxidative metabolism of rotenone in mammals, fish, and insects and its relation to selective toxicity (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidative metabolism of rotenone in mammals, fish, and insects and its relation to selective toxicityJunichi Fukami, Takashi Shishido, Kazuo Fukunaga, and John E. CasidaCite this: J. Agric. Food Chem. 1969, 17, 6, 1217–1226Publication Date (Print):November 1, 1969Publication History Published online1 May 2002Published inissue 1 November 1969https://pubs.acs.org/doi/10.1021/jf60166a048https://doi.org/10.1021/jf60166a048research-articleACS PublicationsRequest reuse permissionsArticle Views591Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Image design: Generation of a prescribed image through a diffraction-limited system with high-contrast recording (1985)

Image restoration involves the recovery of an image which has been distorted by a given imaging system. "Image design," on the other hand, aims at determining the input image which when distorted by an imaging system (e.g., a display device) becomes a desired pattern. The image design problem is encountered in the design of masks for microphotography, microlithography, laser printing, and aids for the visually impaired. In this correspondence, we solve the "image design" problem using linear programming techniques for the case of an imaging system modeled by a band-limited linear system followed by a noninvertible point nonlinearity.
Arbitrarily Primed PCR To Type <i>Vibrio</i> spp. Pathogenic for Shrimp (1999)

A molecular typing study on Vibrio strains implicated in shrimp disease outbreaks in New Caledonia and Japan was conducted by using AP-PCR (arbitrarily primed PCR). It allowed rapid identification of isolates at the genospecies level and studies of infraspecific population structures of epidemiological interest. Clusters identified within the species Vibrio penaeicida were related to their area of origin, allowing discrimination between Japanese and New Caledonian isolates, as well as between those from two different bays in New Caledonia separated by only 50 km. Other subclusters of New Caledonian V. penaeicida isolates could be identified, but it was not possible to link those differences to accurate epidemiological features. This contribution of AP-PCR to the study of vibriosis in penaeid shrimps demonstrates its high discriminating power and the relevance of the epidemiological information provided. This approach would contribute to better knowledge of the ecology of Vibrio spp. and their implication in shrimp disease in aquaculture.
Improving the Labeling of<i>S</i>-Acetyl NHS−MAG<sub>3</sub>-Conjugated Morpholino Oligomers (2002)

S-Acetyl MAG(3) (S-acetylmercaptoacetyltriglycine) has been used as a chelator for the (99m)Tc labeling of a variety of biomolecules. The objective of this study was to improve upon the labeling of morpholino (MORF), a DNA analogue, as a model biomolecule. A 15mer MORF with a primary amine was conjugated with NHS-MAG(3) in the usual manner, and the MORF-MAG(3) was purified over a P4 column as before. The conjugate was radiolabeled using stannous ion as usual, and the impurities were identified using size exclusion high-performance liquid chromatography (SE HPLC). Various methods were then investigated to remove the impurities. With tartrate as the transchelator, two impurities were identified as labeled MAG(3) and labeled tartrate. The labeled MAG(3) could not be removed by simply repurifying the conjugate using the usual pH 5.2 NH(4)OAc buffer before labeling. However, this impurity could be completely removed if the conjugate was adjusted to pH 7.6 and heated before repurification. The labeled tartrate impurity was removed by heating during labeling. On the basis of these observations, the following procedure for purification of the conjugation mixture and subsequent labeling was adopted. After MORF was conjugated with NHS-MAG(3) and purified over P4 with pH 5.2 NH(4)OAc eluant, the oligomer fractions were combined, adjusted to pH 7.6, and heated in a boiling water bath for 20 min. The conjugated oligomer was then repurified over P4 for storage at refrigerator temperatures. Labeling is achieved simply by adding fresh stannous ion to a solution of the MORF-MAG(3) in pH 7.6 containing tartrate followed by (99m)Tc-pertechnetate. After the mixture is heated for 20 min in boiling water, the labeling efficiency is always over 90% as determined by size exclusion HPLC and paper chromatography and the specific activities can exceed 7 mCi/microg. By making several relatively simple changes to the routine procedure used to conjugate and radiolabel biomolecules with (99m)Tc via MAG(3), a modified procedure was developed that results in labeling efficiency high enough to avoid postlabeling purification.
Multi-scale Adaptive Gain Control of IR Images (1997)

IR imagery tends to have a higher dynamic range then typical display devices such as a CRT. Global methods such as stretching and histogram equalization improve the visibility of many images, but some information in the images stays hidden for a human operator. This paper reports about the possibility to represent more information by using local adaptive techniques. Based upon methods found in literature, a new multi-scale method is presented.
Licorice and its potential beneficial effects in common oro‐dental diseases (2011)

Licorice, the name given to the roots and stolons of Glycyrrhiza species, has been used since ancient times as a traditional herbal remedy. Licorice contains several classes of secondary metabolites with which numerous human health benefits have been associated. Recent research suggests that licorice and its bioactive ingredients such as glycyrrhizin, glabridin, licochalcone A, licoricidin, and licorisoflavan A possess potential beneficial effects in oral diseases. This paper reviews the effects of licorice and licorice constituents on both the oral microbial pathogens and the host immune response involved in common ora-dental diseases (dental caries, periodontitis, candidiasis, and recurrent aphthous ulcers). It also summarizes results of clinical trials that investigated the potential beneficial effects of licorice and its constituents for preventing/treating oro-dental diseases.
Purification and characterization of DNA ligase II from <i>Drosophila melanogaster</i> (1990)

Drosophila melanogaster contains DNA ligases I and II. The activity of DNA ligase I is especially high during early embryonic periods, but decreases rapidly afterwards. Although the activity of DNA ligase II is low, it persists throughout all developmental stages. The specific activity of DNA ligase II is high in embryos, but the total activity per body mass was highest in pupae. To characterize the properties of DNA ligase II further and to clarify its differences from DNA ligase I, DNA ligase II was prepared from pupae of D. melanogaster. The enzyme was purified about 3200-fold by ammonium sulfate fractionation (40-70% saturation), phosphocellulose (P11) and Ultrogel column chromatography. Some of the properties have been reported previously. The isoelectric point of DNA ligase II was 6.4 while those of DNA ligase I were 4.9 and 5.8. The optimum pH of DNA ligase II was 7.8-8.1 but 8.0-8.5 for DNA ligase I. The molecular masses of DNA ligase II adducts with AMP were determined as 90 and 70 kDa. These adducts were degraded to 42 and 14.4 kDa by trypsin digestion. For preparation of monoclonal antibodies, a mouse was immunized with the purified enzyme. Two clones, 10-6 and 3-3 IgM, were obtained and purified from mouse ascites. These antibodies showed both binding and neutralizing activities toward DNA ligase II from D. melanogaster, but did not react with DNA ligase I from the same origin. These results showed clearly that DNA ligases I and II have different properties and suggest they have different roles during the developmental stages of D. melanogaster.
Population Trends in the Incidence and Outcomes of Acute Myocardial Infarction (2010)

Within a large community-based population, the incidence of myocardial infarction decreased significantly after 2000, and the incidence of ST-segment elevation myocardial infarction decreased markedly after 1999. Reductions in short-term case fatality rates for myocardial infarction appear to be driven, in part, by a decrease in the incidence of ST-segment elevation myocardial infarction and a lower rate of death after non-ST-segment elevation myocardial infarction.
Intrathecal ziconotide and baclofen provide pain relief in seven patients with neuropathic pain and spasticity: case reports. (2009)

Seven cases of combination of intrathecal (IT) ziconotide and baclofen therapy in patients with refractory neuropathic pain and spasticity were reviewed. Five of the seven adult patients were receiving IT baclofen treatment when ziconotide was initiated. All five patients had experienced at least one previous failed IT treatment regimen. Pain intensity scores improved by a mean of 50.3% with the use of ziconotide-baclofen therapy. Mean time to onset of pain relief was 15 weeks, at a mean ziconotide dose of 3.7 microg/day. Within this group of patients, adverse events were observed in one patient, but they were not considered to be ziconotide related and subsequently resolved. The remaining two patients were receiving ziconotide treatment when baclofen was initiated. Pain intensity scores improved by 75% and 30%, respectively. Pain relief was evident at two weeks and one week, with corresponding ziconotide doses of 2.4 microg/day and 14.4 microg/day, respectively. One patient in this group reported adverse events, but all resolved during continued treatment with the study drugs. Treatment regimens varied between patients in these case series; each regimen used a different titration strategy and different concentrations of ziconotide and baclofen. Combination IT ziconotide and baclofen therapy may be a treatment option for patients with neuropathic pain and spasticity. Future studies are warranted to determine the optimal dosing and titration schedules for ziconotide-baclofen usage.