gebhart/patrepeval huggingface dataset:
New Neutral and Anionic Alkynylgold(I) Complexes <i>via</i> New Synthetic Methods. Crystal and Molecular Structures of [(PPh<sub>3</sub>)<sub>2</sub>N][Au(C⋮CCH<sub>2</sub>OH)<sub>2</sub>], [Au(C⋮CSiMe<sub>3</sub>)(CN<sup>t</sup>Bu)], and [Au(C⋮CR)PR‘<sub>3</sub>] (R‘ = Cyclohexyl, R = CH<sub>2</sub>Cl, CH<sub>2</sub>Br; R‘ = Ph, R = SiMe<sub>3</sub>, <sup>t</sup>Bu) (1997)

[(PPh3)2N][Au(acac)2] (acac = acetylacetonate) reacts with terminal alkynes RC⋮CH to give [(PPh3)2N][Au(C⋮CR)2] (R = H, tBu, SiMe3, CH2X (X = Cl, Br, OH)) complexes. The reactions between [(PPh3)2N][Au(C⋮CH)2] and [(PPh3)2N][AuX2] (X = Cl, Br, I) give [(PPh3)2N][Au(C⋮CH)X] complexes. Neutral mononuclear [Au(C⋮CR)(NHEt2)] (R = SiMe3, tBu), [Au(C⋮CR)(PR‘3)] (R = H, R‘ = Ph, C6H4OMe-4; R = CH2Cl, CH2Br, CH2OH, R‘ = Cy = cyclohexyl; R = SiMe3, R‘ = Ph, C6H4OMe-4, Cy; R = tBu, R‘ = Ph, Cy, C6H4OMe-4), [Au(C⋮CR)(CNtBu)] (R = SiMe3, tBu), and [Au(C⋮CR){C(NHtBu)(NEt2)}] (R = H, SiMe3, tBu) or dinuclear [(AuL)2{μ-C⋮C(CH2)5C⋮C}] (L = PPh3, CNtBu, C(NHtBu)(NEt2)) are obtained via a variety of synthetic methods: (i) reaction between [(PPh3)2N][Au(C⋮CH)2] and [Au(PR3)2]ClO4, (ii) reaction of terminal alkynes with [Au(acac)(L)], (iii) reaction of [AuClL] complexes with terminal alkynes in diethylamine, (iv) substitution reactions (e.g., [Au(C⋮CR)(NHEt2)] + PR‘3), (v) reaction of diethylamine with alkynyl isocyanide derivatives to give alkynylcarbene complexes. The crystal structures of [(PPh3)2N][Au(C⋮CCH2OH)2], [Au(C⋮CSiMe3)(CNtBu)], and [Au(C⋮CR)(PR‘3)] (R‘ = Cy, R = CH2Cl, CH2Br; R‘ = Ph, R = SiMe3, tBu) were determined.
Protective actions of YM737, a new glutathione analog, against cerebral ischemia in rats. (1993)

Effects of YM737[N-(N-r-L-glutamyl-L-cysteinyl)glycine 1-isopropyl ester sulfate monohydrate], a new glutathione (GSH) analog more readily transported into cells than GSH, on cerebral ischemia were compared with those of GSH and some other drugs in rats subjected to occlusion of the bilateral carotid arteries. YM737 significantly reduced lethality, increased brain-water levels as measured by both dry-wet and NMR methods, and increased malondialdehyde (MDA) levels in the cerebral ischemic rats. On the other hand, pharmacological actions of GSH itself was less than those of YM737. In the ischemic rats used in the present study, there was no significant difference in 31P-NMR signals between the normal and the cerebral ischemic rats. These results suggest that YM737 showed anti-cerebral ischemic effects presumably due, in part, to inhibition of lipid peroxidative responses.
Inducing Thermal-Awareness in Multicore Systems Using Networks-on-Chip (2009)

Technology scaling imposes an ever increasing temperature stress on digital circuit design due to transistor density, especially on highly integrated systems, such as Multi-Processor Systems-on-Chip (MPSoCs). Therefore,temperature-aware design is mandatory and should be performed at the early design stages. In this paper we present a novel hardware infrastructure to provide thermal control of MPSoC architectures, which is based on exploiting the No interconnects of the baseline system as an active component to communicate and coordinate between temperature sensors scattered around the chip, in order to globally monitor the actual temperature. Then, a thermal management unit and clock frequency controllers adjust the frequency and voltage of the processing elements according to the temperature requirements at run-time. We show experimental results of the infrastructure to implement effective global temperature control policies for a real-life 4-core MPSoC,emulated on an FPGA-based emulation framework.
<i>Formal Structure of Electromagnetics</i> (1963)

Share Icon Share Twitter Facebook Reddit LinkedIn Reprints and Permissions Cite Icon Cite Search Site Citation E. J. Post, Jacques E. Romain; Formal Structure of Electromagnetics. Physics Today 1 September 1963; 16 (9): 67–68. https://doi.org/10.1063/1.3051143 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPhysics Today Search Advanced Search
Influence of Monomer Optical Purity on the Conformation and Properties of Chiral, Donor-Embedded Polybinaphthalenes for Nonlinear Optical Purposes (2004)

A series of chiral, chromophore-functionalized donor-embedded polybinaphthalenes were prepared by a Stille coupling reaction between a diiodo-functionalized chromophore and a bis(trimethyltin)binaphthalene derivative. The optical purity of the chiral binaphthalene monomer was varied, and its influence on the conformation of the polymers was investigated. Differential scanning calorimetry and second-harmonic generation experiments revealed that the mobility of the chromophore in the polymers, prepared from optically impure monomers, is much higher than that in polymers obtained by polymerization of optically pure monomers. Hyper-Rayleigh scattering measurements demonstrated that this difference in mobility is due to a different macromolecular structure.
Activation of the <i>Escherichia coli nfnB</i> gene by MarA through a highly divergent marbox in a class II promoter (2002)

MarA is a global regulator that mediates resistance to multiple environmental hazards such as antibiotics, disinfectants and oxidative stress agents by modulating the expression of a large number of genes in the Escherichia coli chromosome. Two E. coli MarA homologues, SoxS and Rob also control, to different extents, genes in the mar/sox/rob regulon. The controlling element for these proteins is a 20 bp 'marbox' sequence in the promoter region of regulated genes. Using in vitro assays and mutagenesis of promoter fusions in whole cells, we identified the cis regulatory element involved in MarA upregulation of the oxygen-insensitive nitroreductase nfnB gene. MarA binds to a marbox that is highly divergent from the previously proposed consensus (eight differences out of 14 specified nucleotides). Although purified SoxS and Rob proteins, like MarA, activated nfnB transcription in vitro, only constitutive expression of chromosomal marA, but not of soxS and rob genes, affected nfnB expression in whole cells. Increased expression, but limited as compared with MarA, was only achieved by plasmid-mediated overexpression of SoxS and Rob. This study shows that MarA can regulate gene expression through a functional marbox that is considerably divergent from the current consensus sequence. The data suggest that MarA is preferred over SoxS and Rob in upregulating nfnB. The findings imply that other different but physiologically important marbox DNA-MarA interactions take place in the regulation of still uncharacterized members of the mar regulon.
Spontaneous activation of a human proto-oncogene. (1983)

It has been recently shown that malignant activation of the c-has/bas proto-oncogene in T24 human bladder carcinoma cells was mediated by a single point mutation. A deoxyguanosine located at position 35 of the first exon of this proto-oncogene was substituted by thymidine. These findings predicted that the resulting oncogene would code for a structurally altered p21 protein containing valine instead of glycine as its 12th amino acid residue. We now report the spontaneous activation of the human c-has/bas proto-oncogene during transfection of NIH/3T3 cells. As in T24 cells, this in vitro activated oncogene also acquired malignant properties by a single point mutation. In this case we have detected a G leads to A transition, which occurred at the same position as the mutation responsible for the activation of the T24 oncogene. These results predict that the p21 protein coded for by the spontaneously activated c-has/bas gene will incorporate aspartic acid as its 12th amino acid residue. Computer analysis of the secondary structure of c-has/bas encoded p21 proteins indicates that substitution of the glycine residue located at position 12, not only by aspartic acid or valine but also by any other amino acid, would result in the same structural alteration. These findings indicate that a specific conformational change is sufficient to confer transforming properties to this p21 protein. Moreover, they predict that any mutation affecting the coding properties of the 12th codon of the c-has/bas proto-oncogene will lead to its malignant activation.
A Novel Action of Human Apurinic/Apyrimidinic Endonuclease (2000)

beta-l-Dioxolane-cytidine (l-OddC, BCH-4556, Troxacitabine) is a novel unnatural stereochemical nucleoside analog that is under phase II clinical study for cancer treatment. This nucleoside analog could be phosphorylated and subsequently incorporated into the 3' terminus of DNA. The cytotoxicity of l-OddC was correlated with the amount of l-OddCMP in DNA, which depends on the incorporation by DNA polymerases and the removal by exonucleases. Here we reported the purification and identification of the major enzyme that could preferentially remove l-OddCMP compared with dCMP from the 3' termini of DNA in human cells. Surprisingly, this enzyme was found to be apurinic/apyrimidinic endonuclease (APE1) (), a well characterized DNA base excision repair protein. APE1 preferred to remove l- over d-configuration nucleosides from 3' termini of DNA. The efficiency of removal of these deoxycytidine analogs were as follows: l-OddC > beta-l-2',3'-dideoxy-2', 3'-didehydro-5-fluorocytidine > beta-l-2',3'-dideoxycytidine > beta-l-2',3'-dideoxy-3'-thiocytidine > beta-d-2',3'-dideoxycytidine > beta-d-2',2'-difluorodeoxycytidine > beta-d-2'-deoxycytidine >/= beta-d-arabinofuranosylcytosine. This report is the first demonstration that an exonuclease can preferentially excise l-configuration nucleoside analogs. This discovery suggests that APE1 could be critical for the activity of l-OddC or other l-nucleoside analogs and may play additional important roles in cells that were not previously known.
The Effect of Rosiglitazone on the Liver: Decreased Gluconeogenesis in Patients with Type 2 Diabetes (2006)

RSG increases peripheral tissue insulin sensitivity and decreases endogenous glucose release via an inhibition of gluconeogenesis.
A study of the mechanism of action of novel inhibitors of tumour cell invasion (2008)

Metastasis is the leading cause of death in cancer patients. Tumour invasion and migration are critical aspects of metastatic progression. A forward chemical genetics project was initiated in an effort to identify novel compounds that inhibit tumour invasion. After screening a natural extract library, two novel inhibitors were identified: motuporamine C (MotC) and strongylophorine-26 (STP-26). Structure-activity studies identified dihdyromotuporamine C (dhMotC) as a potent and easily synthesized analogue. In this work, the mechanism of activity of dhMotC and STP-26 was investigated. It was found that both dhMotC and STP-26 affect cellular shape. dhMotC induced thick central actin stress fibres and large focal adhesions and caused cells to contract. STP-26 also induced adhesion formation but it reduced stress fibres and caused increased cell spreading. Both inhibitors activated Rho GTPase, a result which was shown to mediate, in large part, the anti-invasion activity of these molecules. Motuporamines also induce the formation of membrane-rich inclusions at the peri-nuclear region in cells. Motuporamines cause an increase in lysosomal pH and inhibit lysosomal function, such that EGFR/EGF complexes internalized in the presence of dhMotC do not get degradad. This inhibition of EGF degradation is not dependent on Rho activity. However, the anti-invasive activity of motuporamine analogues correlates well with their ability to induce the formation of membrane-rich inclusions. Thus, alteration in membrane trafficking or degradation of cellular membranes may be mechanistically related to the anti-invasion effect of motuporamines. A systematic genome-wide yeast haploinsufficiency screen was employed in an effort to identify possible targets of dhMotC. Yeast screening resulted in a list of 21 mutant strains which showed increased drug sensitivity. Sphingolipid biosynthesis was identified as a target in yeast cells. By testing other genes from the list, ARF1 was identified as a target that partially mediates the anti-invasive activity in human cells. The results of this body of work show that Rho and ARF1 are important molecular players in the mechanism of tumour cell invasion. This knowledge will contribute to the development of future anti-metastasis therapies and to the development of small molecules for use as biological probes to investigate the molecular basis of metastasis.
Encoding Pheromonal Signals in the Accessory Olfactory Bulb of Behaving Mice (2003)

Many mammalian species rely on pheromones-semiochemicals produced by other members of the same species-to communicate social status and reproductive readiness. To assess how the central nervous system integrates the complex repertoire of pheromones, we recorded from single neurons in the accessory olfactory bulb, a nucleus that processes pheromonal signals, of male mice engaged in natural behaviors. Neuronal firing was robustly modulated by physical contact with male and female conspecifics, with individual neurons activated selectively by specific combinations of the sex and strain of conspecifics. We infer that mammals encode social and reproductive information by integrating vomeronasal sensory activity specific to sex and genetic makeup.
Characterization of Reaction Intermediates of Human Excision Repair Nuclease (1997)

Nucleotide excision repair in humans is a complex reaction involving 14 polypeptides in six repair factors for dual incisions on either sides of a DNA lesion. To identify the reaction intermediates that form by the human excision repair nuclease, we adopted three approaches: purification of functional DNA.protein complexes, permanganate footprinting, and the employment as substrate of presumptive DNA reaction intermediates containing unwound sequences 5' to, 3' to, or encompassing the DNA lesion. The first detectable reaction intermediate was formed by substrate binding of XPA, RPA, XPC.HHR23B plus TFIIH (preincision complex 1, PIC1). In this complex the DNA was unwound on either side of the lesion by no more than 10 bases. Independent of the XPG nuclease function, the XPG protein stabilized this complex, forming a long lived preincision complex 2 (PIC2). The XPF.ERCC1 complex bound to PIC2, forming PIC3, which led to dual incisions and the release of the excised oligomer. With partially unwound DNAs, thymine cyclobutane dimer was excised at a fast rate independent of XPC.HHR23B, indicating that a major function of this protein is to stabilize the unwound DNA or to aid lesion unwinding in preincision complexes.
ALIPHATIC GERMANIUM DERIVATIVES. I. TRIETHYLGERMANIUM COMPOUNDS; SOME OF THEIR PROPERTIES AND REACTIONS (1932)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTALIPHATIC GERMANIUM DERIVATIVES. I. TRIETHYLGERMANIUM COMPOUNDS; SOME OF THEIR PROPERTIES AND REACTIONSCharles A. Kraus and E. Alison FloodCite this: J. Am. Chem. Soc. 1932, 54, 4, 1635–1644Publication Date (Print):April 1, 1932Publication History Published online1 May 2002Published inissue 1 April 1932https://pubs.acs.org/doi/10.1021/ja01343a061https://doi.org/10.1021/ja01343a061research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cache designs with partial address matching (1994)

One critical aspect in designing set-associative cache at high clock rate is deriving timely results from directory lookup. In this paper we investigate the possibility of accurately approximating the results of conventional directory search with faster matches of few partial address bits. Such fast and accurate approximations may be utilized to optimize cache access timing, particularly in a customized design environment. Through analytic and simulation studies we examine the trade-offs of various design choices. We also discuss few other applications of partial address matching to computer designs.
Stereotactic pallidotomy for the treatment of Parkinson's disease (1998)

We evaluated the safety and efficacy of microelectrode-guided stereotactic pallidotomy in patients with advanced Parkinson's disease (PD). Using diagnostic criteria and evaluations outlined in the Core Assessment Programme in Transplantation (CAPIT) protocol, we studied unilateral pallidotomy in 26 patients with advanced idiophatic PD, motor fluctuations, and peak dose dyskinesias. All underwent unilateral stereotactic pallidotomy. Assessments conducted in the "practically defined off" and "best on" states at baseline and at 1 and 6 months postoperatively included Unified Parkinson's Disease Rating Scale (UPDRS) parts II, III, and IV and timed motor testing as outlined in CAPIT. Motor UPDRS in the "off" state improved at 1 and 6 months after surgery (p = 0.002, p = 0.008) Likewise, the sum of individual "off" contralateral motor UPDRS items improved (p = 0.0002, p = 0.0005). The duration (p = 0.0001 at 1 and p = 0.001 at 6 months) and severity (p = 0.003 at 1 and p = 0.0005 at 6 months) of dyskinesia improved, but other aspects of the "on" function were unchanged. Serious adverse effects occurred in eight patients and included one fatal deep and three nonfatal frontal lobe hemorrhages with resultant language or behavioral deficits. Nonhemorrhagic complications included one hemiparesis and three frontal lobe syndromes. Pallidotomy improves PD motor disability in the "off" state. Peak dose dyskinesias are reduced, although other aspects of "on" motor function are unchanged. Although morbidity may limit its use, pallidotomy is effective in targeting particular symptoms such as unremitting dyskinesia and severe "off" motor disability in advanced PD.
RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls (2012)

Serum microvesicle RNA from patients with glioblastoma multiforme has significantly down-regulated levels of RNAs coding for ribosome production, compared to normal healthy controls, but a large overabundance of RNA of unknown origin with size < 500 nt.
Inhibitor of differentiation 4 (Id4) is a potential tumor suppressor in prostate cancer (2009)

The results suggest that Id4 acts directly as a tumor suppressor by influencing a hierarchy of cellular processes at multiple levels that leads to a decreased cell proliferation and change in morphology that is possibly mediated through induction of previously silenced tumor suppressors.
Översikt av det internationella geologiska samarbetet (1969)

Abstract 1960-talet har liinnetecknats av ökat organiserat vetenskapligt saniarbete, inte minst genom tillkomsten av internationella vetenskapliga unioner och ett topporgan for dessa, International Council of Scientific Unions (ICSU). Till dessa h6r Inter- national Union of Geological Sciences (IUGS), i det följande kallad geologunionen. Betråffande både organisation och arbetsformer har unionen provat sig fram till nuvarande forhillanden, som Pr ganska svira att overblicka. Unionen hat nu fitt organisatorisk ryggrad och stor amnesbredd. hiinga organisationer har anslutits. Omfattande tvårvetenskapliga forskningsprojekt Ir p i ging. Det har lange forelegat behov av en Ziversikt av det internationella geologiska forskningsfiltet. Foljande glimtar grundar sig främst på geologunionens publikationer, uppgifter frin kolleger i och utanfor Svenska nationalkommitttn fiir geologi samt egen erfarenhet.
QoE Assessment of Multi-View Video and Audio IP Transmission (2010)

In this paper, we discuss QoE (Quality of Experience) requirements for MVV (Multi-View Video) and audio transmission over IP networks and study the effect of the playout buffering time, contents and viewpoint change interfaces on the QoE and user's behavior. Unlike previous works, which mainly discuss MVV transmission from aspects of video codecs, we study MVV and audio transmission under various IP traffic and delay conditions by experiment. We compare two schemes: a scheme that the user watches from a single viewpoint and the one that he/she can choose one viewpoint from many ones. As a result, we show that the users prefer the scheme where they can choose one viewpoint from many ones. We have found that when using proper buffering time, the users feel faster viewpoint changes; it improves their satisfaction compared to that when they watch on a single viewpoint. We have also noticed that the user pays more attention to the degradation of the video when watching on a single viewpoint. We have observed that the users tend to change the viewpoint more frequently in light traffic and low delay.
IL-4 inhibits the expression of IL-8 from stimulated human monocytes. (1990)

Peripheral blood monocytes are important mediators of inflammation via the generation of various bioactive substances, including the recently isolated and cloned chemotactic peptide IL-8. Through cytokine networking, monocyte-derived cytokines are capable of inducing IL-8 expression from non-immune cells. IL-4, a B and T lymphocyte stimulatory factor, has recently been shown to inhibit monocyte/macrophage function, including the ability to suppress monocyte-generated cytokines. We describe the in vitro inhibition of IL-8 gene expression and synthesis from LPS, TNF, and IL-1 stimulated peripheral blood monocytes by IL-4. IL-4 suppressed IL-8 production from stimulated monocytes in a dose-dependent fashion, with partial suppression observed at IL-4 concentrations as low as 10 pg/ml. The IL-4-induced suppressive effects were observed even when IL-4 was administered 2 h post-LPS-stimulation. The IL-4-induced inhibition of IL-8 mRNA expression was dependent on protein synthesis, as the suppressive effects of IL-4 were significantly negated by the addition of cycloheximide. Our findings suggest that IL-4 may be an important endogenous regulator of inflammatory cell recruitment, and adds further support to the potential role of IL-4 as a down-regulator of monocyte immune function.