gebhart/patrepeval huggingface dataset:
The impact of electrode characteristics on electrocorticography (ECoG) (2011)

Used clinically since Penfield and Jasper's pioneering work in the 1950's, electrocorticography (ECoG) has recently been investigated as a promising technology for brain-computer interfacing. Many researchers have attempted to analyze the properties of ECoG recordings, including prediction of optimal electrode spacing and the improved resolution expected with smaller electrodes. This work applies an analytic model of the volume conductor to investigate the sensitivity field of electrodes of various sizes. The benefit to spatial resolution was minimal for electrodes smaller than ~1mm, while smaller electrodes caused a dramatic decrease in signal-to-noise ratio. The temporal correlation between electrode pairs is predicted over a range of spacings and compared to correlation values from a series of recordings in subjects undergoing monitoring for intractable epilepsy. The observed correlations are found to be much higher than predicted by the analytic model and suggest a more detailed model of cortical activity is needed to identify appropriate ECoG grid spacing.
The Location of the Bromelain Cleavage Site in a Hong Kong Influenza Virus Haemagglutinin (1981)

The site of bromelain cleavage in the haemagglutinin of the Hong Kong influenza virus A/Memphis/102/72 has been determined by using a diagonal peptide mapping procedure on the thermolytic digest of amidated BHA. The data show that bromelain cleavage removes the C-terminal 46 residues from HA2, and that the new carboxyl-terminal residue of BHA2 is Gly 175. This is close to the beginning of the hydrophobic membrane-interacting sequence that starts at residue 183.
A peptide inhibitor of c-Jun NH<sub>2</sub>-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo (2006)

The c-Jun NH(2)-terminal kinase (JNK) pathway of the mitogen-activated protein kinase (MAPK) signaling cascade regulates cell function and survival after stress stimulation. Equally robust studies reported dichotomous results suggesting both protective and detrimental effects of JNK during myocardial ischemia-reperfusion (I/R). The lack of a highly specific JNK inhibitor contributed to this controversy. We recently developed a cell-penetrating, protease-resistant peptide inhibitor of JNK, d-JNKI-1. Here we report on the effects of d-JNKI-1 in myocardial I/R. d-JNKI-1 was tested in isolated-perfused adult rat hearts. Increased activation of JNK, p38-MAPK, and extracellular signal-regulated kinase-1/2 (ERK1/2), as assessed by kinase assays and Western blotting, occurred during I/R. d-JNKI-1 delivered before onset of ischemia prevented the increase in JNK activity while not affecting ERK1/2 and p38-MAPK activation. JNK inhibition reduced ischemic injury, as manifested by increased time to contracture (P < 0.05) and decreased left ventricular end-diastolic pressure during ischemia (P < 0.01), and enhanced posthypoxic recovery of systolic and diastolic function (P < 0.01). d-JNKI-1 reduced mitochondrial cytochrome-c release, caspase-3 activation, and the number of apoptotic cells determined by terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (P < 0.05), indicating suppression of the mitochondrial machinery of apoptosis. d-JNKI-1 delivered at the time of reperfusion did not improve functional recovery but still prevented apoptosis. In vivo, d-JNKI-1 reduced infarct size after coronary artery occlusion and reperfusion by approximately 50% (P < 0.01). In conclusion, d-JNKI-1 is an important compound that can be used in preclinical models to investigate the role of JNK signaling in vivo. Inhibition of JNK during I/R is cardioprotective in anesthetized rats in vivo.
Transmittance and reflectance of a coated substrate with application to index measurement of thin films (1978)

Equations are derived for the transmittance and reflectance of a coated substrate of finite thickness. These equations are valid for thick substrates and thin films whose surfaces are specularly reflecting. It is found that the results are in good agreement with spectrophotometer readings of corresponding laboratory samples. Based upon the present results, a simple technique for calculating the refractive index of thin films from photometer readings is given.
Benzidine rearrangement and the detection of trace quantities of blood. A laboratory experiment in criminalistics (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBenzidine rearrangement and the detection of trace quantities of blood. A laboratory experiment in criminalisticsJack L. Pinkus and Lyle S. Goldman Cite this: J. Chem. Educ. 1977, 54, 6, 380Publication Date (Print):June 1, 1977Publication History Received3 August 2009Published online1 June 1977Published inissue 1 June 1977https://doi.org/10.1021/ed054p380Request reuse permissionsArticle Views166Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Platelet-activating factor receptor-mediated calcium influx in NG 108-15 cells. (1993)

Platelet-activating factor (PAF) elicited an increase in intracellular Ca2+ concentration, [Ca2+]i, in neuroblastoma x glioma hybrid NG 108-15 cells as measured by fura-2 fluorescence method. The rise in [Ca2+]i was primarily due to the influx of Ca2+ from extracellular source. Preincubation of cells with the Ca(2+)-ion channel blockers, including verapamil, nifedipine and conotoxin, did not affect the Ca(2+)-response stimulated by PAF, indicating that the PAF-elicited Ca(2+)-influx is not mediated through the classical voltage-dependent Ca(2+)-ion channels. In contrast, SK&F 96365, which is an inhibitor of receptor-operated calcium channel, blocked the PAF-elicited Ca(2+)-response dose-dependently. When cells were pretreated with the protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), PAF-elicited Ca(2+)-signal was diminished substantially. In contrast, the protein kinase A activator, forskolin, has no effect on the Ca(2+)-response induced by PAF. Further experiment demonstrated that genistein, an inhibitor of tyrosine kinase, also caused inhibition on PAF-induced Ca(2+)-response significantly. There results suggest that the PAF receptor-coupled Ca(2+)-ion channel is subjected to the modulation by protein kinase C and tyrosine-specific kinase. Pretreatment of cells with PAF resulted in the desensitization of the Ca(2+)-response following further stimulation with the same agonist. The heterologous desensitization of the PAF-induced Ca2+ influx was also observed in cells pretreated with bradykinin or to a less extent with ATP. Conversely, pretreatment of cells with PAF affected only partially the Ca(2+)-response elicited by bradykinin or ATP. Additive response was observed when PAF and ATP were added together but not PAF and bradykinin.
W<scp>ATER</scp>-W<scp>AVE</scp> I<scp>MPACT ON</scp> W<scp>ALLS</scp> (2002)

▪ Abstract The more violent impacts of water waves on walls create velocities and pressures having magnitudes much larger than those associated with the propagation of ordinary waves under gravity. Insight into these effects has been gained by irrotational-flow computations and by investigating the role of entrained and trapped air in wave impacts. This review focuses on the results of theoretical work, making particular note of the value of considering pressure impulse, and highlights the aspects that are poorly understood.
Centchroman—a non‐steroidal anti‐cancer agent for advanced breast cancer: Phase‐II study (1989)

Treatment with Centchroman (3,4-trans-2,2-dimethyl-3-phenyl-4-p-(beta-pyrrolidinoethoxy) phenyl-7-methoxy chroman) has been evaluated in 4 male and 75 female patients with advanced breast cancer. The overall response rate, including both male and female cases, was 40.5%. Among the female patients, the overall response rate was 38.7%. The median duration of response was 6 months. One of the 4 male patients showed a complete response and 2 showed partial responses. The responses were more marked for bone, pulmonary, soft tissue, skin and lymph-node metastases than for liver metastases.
Clinical Validity of the Lung Cancer Biomarkers Identified by Bioinformatics Analysis of Public Expression Data (2007)

Identification of molecular markers often leads to important clinical applications such as early diagnosis, prognosis, and drug targeting. Lung cancer, the leading cause of cancer-related deaths, still lacks reliable molecular markers. We have combined the bioinformatics analysis of the public gene expression data and clinical validation to identify biomarker genes for non-small-cell lung cancer. The serial analysis of gene expression and the expressed sequence tag data were meta-analyzed to produce a list of the differentially expressed genes in lung cancer. Through careful inspection of the predicted genes, we selected 20 genes for experimental validation using semiquantitative reverse transcriptase-PCR. The microdissected clinical specimens used in the study consisted of three groups: lung tissues from benign diseases and the paired (cancer and pathologic normal) tissues from non-small-cell lung cancer patients. After extensive statistical analyses, seven genes (CBLC, CYP24A1, ALDH3A1, AKR1B10, S100P, PLUNC, and LOC147166) were identified as potential diagnostic markers. Quantitative real-time PCR was carried out to additionally assess the value of the seven identified genes leading to the confirmation of at least two genes (CBLC and CYP24A1) as highly probable novel biomarkers. The gene properties of the identified markers, especially their relationship to lung cancer and cell signaling pathway regulation, further suggest their potential value as drug targets as well.
Modulation of human T cell production of migration inhibitory lymphokines by cytokines derived from human leukocyte dialysates. (1984)

Human leukocyte dialysates contain components capable of amplifying cutaneous delayed-type hypersensitivity (DTH) reactions. In the present study, two such amplifiers, both less than 3500 m.w., were partially purified from human leukocyte dialysates by gel filtration on Sephadex G-10 followed by high pressure reverse-phase liquid chromatography. These amplifiers of DTH were examined for their effects on production of the migration inhibitory lymphokines leukocyte migration inhibition factor (LIF) and macrophage migration inhibition factor (MIF). The amplifiers were found to increase LIF and MIF production by antigen- or alloantigen-stimulated human peripheral blood lymphocytes in a dose-dependent fashion. Further analysis demonstrated that although antigen-stimulated T4 and T8 cell subpopulations could produce LIF activity under the assay conditions employed, amplification of lymphokine production by modulator was only observed with the T4 subset.
Expression cloning (2006)

We present a novel approach to producing facial expression animations for new models. Instead of creating new facial animations from scratch for each new model created, we take advantage of existing animation data in the form of vertex motion vectors. Our method allows animations created by any tools or methods to be easily retargeted to new models. We call this process expression cloning and it provides a new alternative for creating facial animations for character models. Expression cloning makes it meaningful to compile a high-quality facial animation library since this data can be reused for new models. Our method transfers vertex motion vectors from a source face model to a target model having different geometric proportions and mesh structure (vertex number and connectivity). With the aid of an automated heuristic correspondence search, expression cloning typically requires a user to select fewer than ten points in the model. Cloned expression animations preserve the relative motions, dynamics, and character of the original facial animations.
Optimization of High Molecular Weight Pullulan Production by <i>Aureobasidium pullulans</i> in Batch Fermentations (2002)

Of five strains of Aureobasidium pullulans studied, NRRL Y-2311-1 yielded the highest titer (26.2 g/L) of pullulan and formed the lowest amount of melanin-like pigment. Sucrose was superior to glucose as the carbon and energy source on the basis of yield and titer of pullulan produced. Pullulan titer was higher (26.2 vs 5.1 g/L), biomass concentration was lower (6.9 vs 12.7 g/L), and DO was lower (0 vs 60% of saturation) when the fermenter was agitated by a marine propeller compared to Rushton impellers. Pullulan produced by strain NRRL Y-2311-1 ranged in weight-average molar mass (M(w)) from 486 KDa and number-average molar mass (M(n)) from 220 Da on day 1 of growth to 390 KDa and 690 Da on day 6; M(w) declined by about 35% from day 1 to day 3, the day of maximum pullulan titer. For the other strains, the ranges of molar mass on the day of maximum pullulan titer were 338-614 KDa (M(w)) and 100-6820 Da (M(n)).
The Locus of Enterocyte Effacement (LEE)-Encoded Regulator Controls Expression of Both LEE- and Non-LEE-Encoded Virulence Factors in Enteropathogenic and Enterohemorrhagic <i>Escherichia coli</i> (2000)

Regulation of virulence gene expression in enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) is incompletely understood. In EPEC, the plasmid-encoded regulator Per is required for maximal expression of proteins encoded on the locus of enterocyte effacement (LEE), and a LEE-encoded regulator (Ler) is part of the Per-mediated regulatory cascade upregulating the LEE2, LEE3, and LEE4 promoters. We now report that Ler is essential for the expression of multiple LEE-located genes in both EPEC and EHEC, including those encoding the type III secretion pathway, the secreted Esp proteins, Tir, and intimin. Ler is therefore central to the process of attaching and effacing (AE) lesion formation. Ler also regulates the expression of LEE-located genes not required for AE-lesion formation, including rorf2, orf10, rorf10, orf19, and espF, indicating that Ler regulates additional virulence properties. In addition, Ler regulates the expression of proteins encoded outside the LEE that are not essential for AE lesion formation, including TagA in EHEC and EspC in EPEC. delta ler mutants of both EPEC and EHEC show altered adherence to epithelial cells and express novel fimbriae. Ler is therefore a global regulator of virulence gene expression in EPEC and EHEC.
Using Apex/CPM_GOMS to develop human-like software agents (2003)

Here we report on the development of software agents with human-like performance characteristics for use in simulations of new airspace concepts. The goal of our effort is to use the agents to evaluate the impact of new technologies, such as widespread automation, on the workload and situation awareness of air traffic controllers. Our approach combines a task analysis, which provides a functional description of the domain, with a human performance architecture, from which detailed performance predictions can be made. We are in the preliminary stage of agent development. Here we will focus on how a standard task analysis can be paired with a human performance model to generate behavior that approximates that of the human user. We will also discuss the simulation environment and our progress to date.
Deep Learning on FPGAs: Past, Present, and Future (2016)

The rapid growth of data size and accessibility in recent years has instigated a shift of philosophy in algorithm design for artificial intelligence. Instead of engineering algorithms by hand, the ability to learn composable systems automatically from massive amounts of data has led to ground-breaking performance in important domains such as computer vision, speech recognition, and natural language processing. The most popular class of techniques used in these domains is called deep learning, and is seeing significant attention from industry. However, these models require incredible amounts of data and compute power to train, and are limited by the need for better hardware acceleration to accommodate scaling beyond current data and model sizes. While the current solution has been to use clusters of graphics processing units (GPU) as general purpose processors (GPGPU), the use of field programmable gate arrays (FPGA) provide an interesting alternative. Current trends in design tools for FPGAs have made them more compatible with the high-level software practices typically practiced in the deep learning community, making FPGAs more accessible to those who build and deploy models. Since FPGA architectures are flexible, this could also allow researchers the ability to explore model-level optimizations beyond what is possible on fixed architectures such as GPUs. As well, FPGAs tend to provide high performance per watt of power consumption, which is of particular importance for application scientists interested in large scale server-based deployment or resource-limited embedded applications. This review takes a look at deep learning and FPGAs from a hardware acceleration perspective, identifying trends and innovations that make these technologies a natural fit, and motivates a discussion on how FPGAs may best serve the needs of the deep learning community moving forward.
Automatic characterization of stride parameters in canines with a single wearable inertial sensor (2018)

We have developed and validated an IMU method for automatic canine gait analysis. Our method can be used for studying neuromuscular diseases in veterinary clinics and in translational research.
Ovicidal activity and its relation to chemical structure for the two-spotted spider mite (Tetranychus urticae Koch) in a new class of miticides containing the cyclopropyl group (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOvicidal activity and its relation to chemical structure for the two-spotted spider mite (Tetranychus urticae Koch) in a new class of miticides containing the cyclopropyl groupClive A. Henrick, W. Edward Willy, Gerardus B. Staal, and George F. LudvikCite this: J. Agric. Food Chem. 1976, 24, 5, 1023–1029Publication Date (Print):May 1, 1976Publication History Published online1 May 2002Published inissue 1 May 1976https://pubs.acs.org/doi/10.1021/jf60207a017https://doi.org/10.1021/jf60207a017research-articleACS PublicationsRequest reuse permissionsArticle Views181Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
In-office vital tooth bleaching--what do lights add? (2003)

Aqueous hydrogen peroxide (H2O2) has been used clinically at 30% to 35% levels to lighten teeth for many years, but the process has required multiple visits. Heat and light have been used empirically in attempts to catalyze H2O2 decomposition and speed tooth lightening. The contribution of bleaching lights (LumaArch, Optilux 500, and Zoom!) to act as catalysts for lightening teeth was studied in 83 pairs of contralateral anterior maxillary and mandibular teeth on 15 human subjects. Split-arch design using centrals, laterals, and canines on one side treated with bleach plus light, were compared with contralateral teeth using bleach alone. Three researchers trained in the use of the Vitapan 3D-Master Shade Guide took shades with independently agreement within 0.5 value-chroma sum 89% of the time throughout the study Laboratory tests determined bleach gel chemistry, bleach light output, and effects on the bleaches of light alone and heat alone. Results showed that the three test lights did not lighten teeth more than their bleach gels alone. All teeth lightened to nearly the same degree (1.7 color increments), but LumaArch required 60% less time and Zoom! used 1/3 lower H2O2 concentration. Laboratory tests indicated that the proprietary chemicals mixed into each bleach gel just before use acted as catalysts and were probably responsible for more rapid lightening produced by LumaArch gel, and need for less H2O2 in Zoom! gel. Neither the heat produced by the accessory lights, nor the light output itself were responsible for catalytic activity with any of the three systems tested. Collectively, the data demonstrate positive effects from chemical catalysts added to bleaching gels. No output from any of the lights resulted in heat or light that catalyzed the gels.
Experiments on the flow past a circular cylinder at very high Reynolds number (1961)

Measurements on a large circular cylinder in a pressurized wind tunnel at Reynolds numbers from 10 6 to 10 7 reveal a high Reynolds number transition in which the drag coefficient increases from its low supercritical value to a value 0.7 at R = 3.5 × 10 6 and then becomes constant. Also, for R > 3.5 × 10 6 , definite vortex shedding occurs, with Strouhal number 0.27.
Recent Topics in NMR Imaging and MRI (2002)

NMR and NMR imaging (MRI) are finding increasing use not only in the clinical and medical fields, but also in material, physicochemical, biological, geological, industrial and environmental applications. This short review is limited to two topics: (i) new techniques and pulse sequences and their application to non-clinical fields that may have clinical application; and (ii) new trends in MR contrast agents. The former topic addresses pulse sequence and data analysis; dynamics such as diffusion, flow, velocity and velocimetry; chemometrics; pharmacological agents; and chemotherapy; the latter topic addresses contrast agents (CA) sensitive to biochemical activity; CA based on water exchange; molecular interactions and stability of CA; characteristics of emerging CA; superparamagnetic CA; and macromolecular CA.
Tunable negative refraction in nematic liquid crystals (2006)

A tunable negative refraction mechanism based on the properties of nematic liquid crystals is proposed. It shows that negative group refraction occurs at the interface between air and the nematic liquid crystals, and that the refraction can be adjusted by an applied electric field and by the temperature. For a nematic liquid crystal (E7, Merck), the group refraction is negative for the voltages of 1.0–2.8V and reaches a maximum at 1.5V. The negative group refraction decreases monotonously with increasing temperature. Such mechanism demonstrates the feasibility of tunable negative refraction devices based on liquid crystals.