gebhart/patrepeval huggingface dataset:
Maturation of Pre-tRNAfMet by Escherichia coli RNase P Is Specified by a Guanosine of the 5′-Flanking Sequence (1995)

The C+1/A+72 base pair at the top of the acceptor stem of Escherichia coli tRNA(fMet) accounts for several of the specialized roles of this tRNA in translation initiation. According to the rules of RNA substrate recognition by RNase P, the C+1/A+72 pair is likely to disfavor the 5'-maturation of pre-tRNA(fMet). Indeed, in contrast to other E. coli tRNA species, tRNA(fMet) was not properly matured when overproduced from a multicopy expression vector. Half of the recovered tRNA(fMet) retained an extension at the 5' side. Such a defect of tRNA(fMet) processing could be cured by changing bases C+1 and A+72 by a Watson-Crick base pair or by non-paired bases, provided one of them was a G. It could also be compensated by either (i) over-expression of RNase P or (ii) introduction within the plasmid of one out of the three 5'-flanking sequences naturally occurring in the four E. coli tRNA(fMet) genes. The effect of these flanking sequences on the maturation of tRNA(fMet) could be accounted for by the presence of a G located 2 bases upstream from C+1. Notably, this G is the only residue that is conserved in the 5'-flanking sequences of all four E. coli tRNA(fMet) genes.
Quality of Life and Affect across the Adult Lifespan (2009)

The premise of this dissertation is based on the work of M. Powell Lawton, in particular his theories of Environmental Press: Lawton and Nahemow, 1973) and the Dual-Channel Hypothesis: Lawton, 1996; Lawton, Winter, Kleban, & Ruckdeschel, 1999). Study 1 used a correlational approach to test Lawton and colleagues: 1999) model in a community sample of people across the adult lifespan, thereby expanding previous findings to individuals under age 60. Study 2 used an experimental approach to determine if individuals are affectively susceptible to differing environmental conditions based on their performance on a cognitive task. Whereas Study 1 provided a naturalistic picture of the interrelationships between affect and how individuals perceive the various facets of their lives, Study 2 allowed for a controlled look at the singular effect of objective environment on affective experience. In the correlational study I found that Lawton's dual channel hypothesis: 1996) was an insufficient model for explaining the relationships between quality of life and affect. The quality of an older adult's physical health directly influenced negative affect and indirectly influenced positive affect by influencing the quality of externally engaging phenomena such as environmental satisfaction and time quality, which in turn directly influenced positive affect. These relationships were replicated in a younger sample, providing further evidence that the dual channel hypothesis is insufficient as a model of quality of life and affect and that these relationships are as complex in younger adults as they are in older adults. The findings from Study 2 contributed to this notion. With age, the more it appears we actively select environmental conditions that allow us to maximize our positive affect and minimize our negative affect. Perhaps most notably is the role personality played in how individuals perceived and managed their environment and how individuals experienced affect. Neurotic individuals were not only more prone to perceive their lives as lower in quality, but they were also more sensitive to poor environmental conditions. These studies reveal the complexity of the relationships between how we perceive our lives, how we experience our environments, and how these perceptions and experiences influence our subjective well-being.
Photochemistry of metal carbonyls (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry of metal carbonylsMark WrightonCite this: Chem. Rev. 1974, 74, 4, 401–430Publication Date (Print):August 1, 1974Publication History Published online1 May 2002Published inissue 1 August 1974https://pubs.acs.org/doi/10.1021/cr60290a001https://doi.org/10.1021/cr60290a001research-articleACS PublicationsRequest reuse permissionsArticle Views2833Altmetric-Citations409LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Active Role for tRNA in Decoding Beyond Codon:Anticodon Pairing (2005)

During transfer RNA (tRNA) selection, a cognate codon:anticodon interaction triggers a series of events that ultimately results in the acceptance of that tRNA into the ribosome for peptide-bond formation. High-fidelity discrimination between the cognate tRNA and near- and noncognate ones depends both on their differential dissociation rates from the ribosome and on specific acceleration of forward rate constants by cognate species. Here we show that a mutant tRNA(Trp) carrying a single substitution in its D-arm achieves elevated levels of miscoding by accelerating these forward rate constants independent of codon:anticodon pairing in the decoding center. These data provide evidence for a direct role for tRNA in signaling its own acceptance during decoding and support its fundamental role during the evolution of protein synthesis.
Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma (2004)

Multiple myeloma (MM) is one of the most common hematologic malignancies. Despite extensive therapeutical approaches, cures remain rare exceptions. An important issue for future immunologic treatments is the characterization of appropriate tumor-associated antigens. Recently, a highly glycosylated mucin MUC1 was detected on a majority of multiple myeloma cell lines. We analyzed bone marrow and peripheral blood of 68 patients with HLA-A2-positive myeloma for the presence and functional activity of CD8 T cells specific for the MUC1-derived peptide LLLLTVLTV. Forty-four percent of the patients with MM contained elevated frequencies of MUC1-specific CD8 T cells in freshly isolated samples from peripheral blood (PB) or bone marrow (BM) compared with corresponding samples from healthy donors. BM-residing T cells possessed a higher functional capacity upon specific reactivation than PB-derived T cells with regard to interferon gamma (IFN-gamma) secretion, perforin production, and cytotoxicity.
A Simple Method for Measuring Si-Fin Sidewall Roughness by AFM (2009)

The gate oxide reliability and the electrical behavior of FinFETs are directly related to the surface characteristics of the fin vertical sidewalls. The surface roughness of the fin sidewalls is one of the most important structural parameters to be monitored in order to optimize the fin patterning and postetch treatments. Because of the nanometer-scale dimensions of the fins and the vertical orientation of the sidewall surface, their roughness measurement is a serious challenge. In this paper, we describe a simple and effective method for measuring the sidewall morphology of silicon fins by conventional atomic force microscopy. The present methodology has been employed to analyze fins as etched by reactive ion etching and fins repaired by sacrificial oxidation. The results show that sacrificial oxidation not only reduces the roughness of the sidewalls, but also rounds the top corners of silicon fins. The present method can also be applied to characterize sidewall roughness of other nanostructures and materials such as the polysilicon gate of transistors or nanoelectromechanical beams.
Wavelet encoding and variable resolution progressive transmission (1993)

Progressive transmission is a method of transmitting and displaying imagery in stages of successively improving quality. The subsampled lowpass image representations generated by a wavelet transformation suit this purpose well, but for best results the order of presentation is critical. Candidate data for transmission are best selected using dynamic prioritization criteria generated from image contents and viewer guidance. We show that wavelets are not only suitable but superior when used to encode data for progressive transmission at non-uniform resolutions. This application does not preclude additional compression using quantization of highpass coefficients, which to the contrary results in superior image approximations at low data rates.
The Application of Computers in Implementing Quality Assurance for Construction Projects (1996)

An operational model of using a computer system in implementing quality assurance for contractors based on research carried out at Hong Kong is reviewed. The model outlines how computer systems could be used to support the management tasks of the management function in quality assurance.
Alloevodionol methyl ether (2001)

The crystal structure determination of one of the substituted α-chromene components isolated in the hexane extraction of the fruit of the indigenous Australian tree Melicope ellyrana, the methyl ether of the known compound alloevodionol, is reported. In this compound, 1-(5,7-di­methoxy-2,2-di­methyl-2H-1-benzo­pyran-8-yl)­ethanone, C15H18O4, the methoxy groups are approximately coplanar with the aromatic ring, while the acetyl group is normal to the ring.
Assessing Mechanisms of Recovery During Robot-Aided Neurorehabilitation of the Upper Limb (2007)

Knowledge of the recovery components and of the associated performance acquisition model may be useful in assessing and training stroke patients and should make it possible to precisely plan and, if necessary, modify the rehabilitation strategies.
TRAINING DEEP NEURAL NETWORKS ON NOISY LABELS WITH BOOTSTRAPPING (2015)

Current state-of-the-art deep learning systems for visual object recognition and detection use purely supervised training with regularization such as dropout to avoid overfitting. The performance depends critically on the amount of labeled examples, and in current practice the labels are assumed to be unambiguous and accurate. However, this assumption often does not hold; e.g. in recognition, class labels may be missing; in detection, objects in the image may not be localized; and in general, the labeling may be subjective. In this work we propose a generic way to handle noisy and incomplete labeling by augmenting the prediction objective with a notion of consistency. We consider a prediction consistent if the same prediction is made given similar percepts, where the notion of similarity is between deep network features computed from the input data. In experiments we demonstrate that our approach yields substantial robustness to label noise on several datasets. On MNIST handwritten digits, we show that our model is robust to label corruption. On the Toronto Face Database, we show that our model handles well the case of subjective labels in emotion recognition, achieving state-of-theart results, and can also benefit from unlabeled face images with no modification to our method. On the ILSVRC2014 detection challenge data, we show that our approach extends to very deep networks, high resolution images and structured outputs, and results in improved scalable detection.
Electrosynthesis and Spectroscopic Characterization of Poly(<i>o</i>-Aminophenol) Film Electrodes (2012)

This review, which is divided into three parts, concerns electrochemical synthesis, spectroscopic characterization, and formation mechanisms of poly( o -aminophenol) (POAP) film electrodes. The first part of this review is devoted to describe the electropolymerization process of o -aminophenol on different electrode materials and in different electrolyte media by employing both potentiodynamic and potentiostatic methods. The second part refers to spectroscopic studies carried out by different authors to both, identify the products of the o -aminophenol electrooxidation and elucidate the chemical structure of poly( o -aminophenol) film electrodes. The third part shows the different mechanisms formulated to interpret the POAP films formation from both acid and basic solutions of o -AP. Also, some electrochemical and spectroscopic data which allowed to propos the corresponding formation mechanisms, especially in basic media, are described.
Nociceptive flexion reflexes elicited by noxious laser radiant heat in man (1979)

This study, carried out in humans, is an attempt to elicit nociceptive flexion reflexes and to investigate the sensation reported by the subjects, using thermal stimulation achieved with laser radiant heat. It was found that noxious termal stimulation elicited long latency nociceptive reflexes very well correlated with a pricking pain. Since thermal stimulus is more specific and natural than an electrical one, it seems that this method should be of interest for pain research in man.
The Binding of Periodicals (1984)

This paper attempts to assess the stages involved in the binding or non-binding of periodicals and the decisions taken at each stage. The quality of binding employed, and choice of binder is discussed, along with the routines of record keeping, chasing, checking invoices. processing and shelving. A small section is devoted to disposal and microforms.
Interlaboratory Standardization of the Measurement of Serum Bactericidal Activity by Using Human Complement against Meningococcal Serogroup B, Strain 44/76-SL, before and after Vaccination with the Norwegian MenBvac Outer Membrane Vesicle Vaccine (2005)

There is currently no standardized serum bactericidal antibody (SBA) assay for evaluating immune responses to meningococcal outer membrane vesicle or protein vaccines. Four laboratories, Manchester Health Protection Agency (MC HPA), New Zealand Institute of Environmental Science and Research Limited (NZ ESR), Norwegian Institute of Public Health (NIPH), and Chiron Vaccines (Chiron), measured SBA titers in the same panel of human sera (n=76) from laboratory staff (n=21) vaccinated with MenBvac. Blood samples were collected prevaccination, prior to each of the three doses of MenBvac given at 6-week intervals, and 6 weeks following the third dose. Initial results showed a number of discrepancies in results between the four participating laboratories. The greatest effect on titers appeared to be due to differences among laboratories in the maintenance of the meningococcal serogroup B test strain, 44/76-SL. A repeat study was conducted using the same frozen isolate (meningococcal serogroup B test strain 44/76-SL), freshly distributed to all four laboratories. Using SBA titers from the tilt method for all samples, and using MC HPA as the comparator, the results were as follows for NZ ESR, NIPH, and Chiron, respectively, using log(10) titers: correlation coefficients (r) were 0.966, 0.967, and 0.936; intercepts were 0.08, 0.15, and 0.17; and slopes were 0.930, 0.851, and 0.891. In both prevaccination and postvaccination samples from 15 subjects assayed by all four laboratories, similar increases in SBA (fourfold or greater) were observed (for 11, 11, 9, and 9 subjects for MC HPA, NZ ESR, NIPH, and Chiron, respectively), and similar percentages of subjects with SBA titers of>or=4 p revaccination and 6 weeks following each dose were found. The SBA assay has been harmonized between the four different laboratories with good agreement on seroconversion rates, n-fold changes in titers, and percentages of subjects with SBA titers of >or=4.
Corrosion Characteristics of Some Magnesium-Zinc-Calcium Alloys (1948)

The resistance to corrosion of 45 cast Mg‐Zn and Mg‐Zn‐Ca alloys was investigated by fourteen day exposure to an alternate immersion test. The data indicate that the corrosion rate increased with increasing zinc content in the range studied which included from 0 to 5.5% zinc. The corrosion rate was sharply reduced by addition of calcium in concentrations from 0.10 to 0.55%.
The Ampoule Method: A Pathway towards Controllable Synthesis of Electrocatalysts for Water Electrolysis (2019)

The ampoule method provides a promising pathway towards the controllable synthesis of novel electrocatalysts for water electrolysis due to its straightforward manipulation of reaction conditions, accessible experimental design, and controlled environment. This Concept introduces the development of the ampoule method and anticipates its application in electrocatalyst synthesis for water electrolysis. First, the history, device configuration, and merits of the ampoule method are briefly introduced. Afterwards, typical materials synthesized by the ampoule method are discussed. Then, recent process in applying the ampoule method to synthesize electrocatalysts for water electrolysis is highlighted. Finally, opportunities and potentials of this method in facilitating electrocatalyst synthesis for water electrolysis are discussed.
Novel SiC-trench-MOSFET with reduced oxide electric field (2004)

It has been shown theoretically that the specific on-resistance of the drift region of SiC metal oxide semiconductor field effect transistor (MOSFET) is about 200 times lower than that of a Si MOSFET with the same breakdown voltage (Bhatnagar and Balaiga, 1993). However, the blocking performance of the trench MOSFET (TMOSFET) is limited by the breakdown of the gate dielectric and not by avalanche breakdown in the SiC (Agarwal et al., 1996). Our analysis indicates that this is because the electric field in the SiO/sub 2/ gate dielectric exceeds the dielectric breakdown field strength when high voltages are being blocked by the MOSFET well before the electric field in the SiC is high enough to cause avalanche breakdown in the semiconductor. This paper will introduce, for the first time, a P-type polysilicon filled trench (P-trench) in the TMOSFET that is deeper than the trench gate. The high electric field stress in the oxide is moved to the corner of the P-trench. Hence, the electric field problem can be solved without the need to replace the SiO/sub 2/ with high dielectric constant gate insulators as suggested by others (Sridevan and Baliga, 1997).
Role of Anticyclic Citrullinated Peptide in the Diagnosis of Early Rheumatoid Factor-Negative Suspected Rheumatoid Arthritis (2006)

Anti-CCP is a useful and highly specific but not absolutely specific or sensitive test to detect RA and supplements rheumatoid factor in the presence of a strong clinical suspicion.
A new machine learning algorithm for removal of salt and pepper noise (2015)

Supervised machine learning algorithm has been extensively studied and applied to different fields of image processing in past decades. This paper proposes a new machine learning algorithm, called margin setting (MS), for restoring images that are corrupted by salt and pepper impulse noise. Margin setting generates decision surface to classify the noise pixels and non-noise pixels. After the noise pixels are detected, a modified ranked order mean (ROM) filter is used to replace the corrupted pixels for images reconstruction. Margin setting algorithm is tested with grayscale and color images for different noise densities. The experimental results are compared with those of the support vector machine (SVM) and standard median filter (SMF). The results show that margin setting outperforms these methods with higher Peak Signal-to-Noise Ratio (PSNR), lower mean square error (MSE), higher image enhancement factor (IEF) and higher Structural Similarity Index (SSIM).
Finite difference method for numerical computation of discontinuous solutions of the equations of fluid dynamics (1959)

International audience
<i>MBTPS2</i> mutation causes BRESEK/BRESHECK syndrome (2011)

BRESEK/BRESHECK syndrome is a multiple congenital malformation characterized by brain anomalies, intellectual disability, ectodermal dysplasia, skeletal deformities, ear or eye anomalies, and renal anomalies or small kidneys, with or without Hirschsprung disease and cleft palate or cryptorchidism. This syndrome has only been reported in three male patients. Here, we report on the fourth male patient presenting with brain anomaly, intellectual disability, growth retardation, ectodermal dysplasia, vertebral (skeletal) anomaly, Hirschsprung disease, low-set and large ears, cryptorchidism, and small kidneys. These manifestations fulfill the clinical diagnostic criteria of BRESHECK syndrome. Since all patients with BRESEK/BRESHECK syndrome are male, and X-linked syndrome of ichthyosis follicularis with atrichia and photophobia is sometimes associated with several features of BRESEK/BRESHECK syndrome such as intellectual disability, vertebral and renal anomalies, and Hirschsprung disease, we analyzed the causal gene of ichthyosis follicularis with atrichia and photophobia syndrome, MBTPS2, in the present patient and identified an p.Arg429His mutation. This mutation has been reported to cause the most severe type of ichthyosis follicularis with atrichia and photophobia syndrome, including neonatal and infantile death. These results demonstrate that the p.Arg429His mutation in MBTPS2 causes BRESEK/BRESHECK syndrome.
Compositional Fuzzing Aided by Targeted Symbolic Execution (2019)

Guided fuzzing has, in recent years, been able to uncover many new vulnerabilities in real-world software due to its fast input mutation strategies guided by path-coverage. However, most fuzzers are unable to achieve high coverage in deeper parts of programs. Moreover, fuzzers heavily rely on the diversity of the seed inputs, often manually provided, to be able to produce meaningful results. In this paper, we present Wildfire, a novel open-source compositional fuzzing framework. Wildfire finds vulnerabilities by fuzzing isolated functions in a C-program and, then, using targeted symbolic execution it determines the feasibility of exploitation for these vulnerabilities. Based on our evaluation of 23 open-source programs (nearly 1 million LOC), we show that Wildfire, as a result of the increased coverage, finds more true-positives than baseline symbolic execution and fuzzing tools, as well as state-of-the-art coverage-guided tools, in only 10% of the analysis time taken by them. Additionally, Wildfire finds many other potential vulnerabilities whose feasibility can be determined compositionally to confirm if they are false-positives. Wildfire could also reproduce all of the known vulnerabilities and found several previously-unknown vulnerabilities in three open-source libraries.