gebhart/patrepeval huggingface dataset:
Viral Hepatitis (1969)

The serum immunoglobulin response was studied in 30 children with infectious hepatitis, MS-1 type and in 28 children with infectious hepatitis, MS-2 type. MS-1 is typical infectious hepatitis (IH) and MS-2 resembles serum hepatitis (SH). IgG, IgM, and IgA levels were determined during the incubation period and acute and convalescent phases of the disease. Infectious hepatitis was characterized by a high increase in IgM levels occurring three to four days after the first evidence of abnormal serum glutamic oxaloacetic transaminase (SGOT) activity. The elevated IgM levels returned to normal 5 to 35 days later. In contrast, SH was usually characterized by only slightly elevated to normal IgM levels during the acute stage of the disease. These studies indicate that the results of serial determinations of immunoglobulin levels performed in conjunction with serial SGOT and thymol turbidity determinations should provide useful data for the differentiation of IH from SH.
Functional array fusion (2001)

This paper introduces a new approach to optimizing array algorithms in functional languages. We are specifically aiming at an efficient implementation of irregular array algorithms that are hard to implement in conventional array languages such as Fortran. We optimize the storage layout of arrays containing complex data structures and reduce the running time of functions operating on these arrays by means of equational program transformations. In particular, this paper discusses a novel form of combinator loop fusion, which by removing intermediate structures optimizes the use of the memory hierarchy. We identify a combinator named loop P that provides a general scheme for iterating over an array and that in conjunction with an array constructor replicate P is sufficient to express a wide range of array algorithms. On this basis, we define equational transformation rules that combine traversals of loop P and replicate P as well as sequences of applications of loop P into a single loop P traversal. Our approach naturally generalizes to a parallel implementation and includes facilities for optimizing load balancing and communication. A prototype implementation based on the rewrite rule pragma of the Glasgow Haskell Compiler is significantly faster than standard Haskell arrays and approaches the speed of hand coded C for simple examples.
Some transistor input stages for high-gain d.c. amplifiers (1958)

The sensitivity of a d.c. amplifier using transistors is mainly limited by the variation with temperature of the inter-electrode potentials and currents of the transistors, the variation between any two temperatures being termed the thermal drift.A typical low-frequency germanium transistor connected as a directly-coupled common-emitter amplifier may introduce current and voltage drifts, referred to the input, of 50 μA and 100 mV, respectively, when the temperature changes from 20 to 500°C. By using two such transistors in a balanced circuit, in which the drifts oppose, the net drifts are reduced to about 1 μA and 2 mV, respectively, if several interdependent component values are adjusted at different temperatures. By selecting transistors, and using greater care in balancing the amplifier, the drift can be reduced by one or two orders of magnitude, but such a procedure is usually unacceptable.The same transistor connected as a simple modulator introduces a fundamental current drift of only 3 μA but it still has a voltage drift of 100 mV. It is thus most suitable for use with devices having a high source impedance such as an ionization chamber for measuring radiation intensity. The current error can be reduced by a factor of 10 to 0.3 μA if two such transistors are used in a balanced modulator which requires only one adjustment at a single temperature.The use of the transistor in a common-emitter chopping circuit results in a current drift of 50 μA and a voltage drift of only 2 mV, while reversing the functions of emitter and collector reduces these drifts to 3 μA and 100 μV, respectively. The latter voltage drift is considerably less than that of most thermionic-valve amplifiers, but the current drift is still large by thermionic-valve standards, and limits the use of the chopper to low-impedance sources.A modification to this chopper eliminates the leakage current, but leaves the voltage drift unchanged at 100 μV. This voltage drift, acting on the transistor impedance, produces a current drift of only 3 × 10−8 amp, which makes this chopper suitable for use with high-impedance sources.The chopper drift figures are obtained without recourse to selection or balancing of tcansistors, and are low enough to enable the transistor to contribute its many other advantages to such applications as sensitive null detectors and analogue computers.The current drift can be reduced still further by using higher-frequency transistors, which, in general, have lower leakage currents. For example, the surface-barrier SB100 transistor (fcα ≃ 50 Mc/s) introduces a maximum current drift of only 3 × 10−9 amp.The silicon junction transistor, promising even lower leakage currents, should enable direct currents of less than 10−11 amp to be measured.
[Molecular diagnosis of oral cavity trichomonas infections in HIV patients]. (2004)

The occurrence of trichomonas in oral cavity of HIV patients is not well known. HIV patients often suffer from oral lesions (candidiosis, advanced caries) and it remains unclear if any oral parasites can affect that, therefore the aim of the study was verification of species that can occur in HIV patients' oral cavity. Diagnosis of oral trichomonas can be performed by conventional methods (microscopic observation of wet and stained preparations and cultivation) but these are time consuming and insufficient for proper species differentiation, therefore in order to detect and identify species of parasites precisely, molecular methods such as PCR (Polymerase Chain Reaction) and sequencing of its product, were applied. 54 HIV patients (18 females and 36 males at the age of 20-54) were examined. All of them were addicted to intravenous drugs for at least 6 years. Saliva, smears and spittle samples were collected and used for cultivation, preparations and molecular diagnosis. For PCR amplification a pair of primers (T1 and T2) specific for ITS 1 - 5.8 SrRNA - ITS 2 region was designed. The oral trichomonas were detected in saliva samples of 3 HIV patients; these were males at the age of 25, 27 and 44. The identification of species by PCR and sequencing of the PCR products showed the trichomonads belonging to Trichomonas tenax. Infection of HIV patients' oral cavity caused by T. tenax is rather related with inflammatory processes than with the immunosuppression of these patients but should be considered as a potential factor in pathogenesis of oral disorders in immunosuppressed patients.
Automatic anatomy recognition via fuzzy object models (2012)

To make Quantitative Radiology a reality in routine radiological practice, computerized automatic anatomy recognition (AAR) during radiological image reading becomes essential. As part of this larger goal, last year at this conference we presented a fuzzy strategy for building body-wide group-wise anatomic models. In the present paper, we describe the further advances made in fuzzy modeling and the algorithms and results achieved for AAR by using the fuzzy models. The proposed AAR approach consists of three distinct steps: (a) Building fuzzy object models (FOMs) for each population group G. (b) By using the FOMs to recognize the individual objects in any given patient image I under group G. (c) To delineate the recognized objects in I. This paper will focus mostly on (b). FOMs are built hierarchically, the smaller sub-objects forming the offspring of larger parent objects. The hierarchical pose relationships from the parent to offspring are codified in the FOMs. Several approaches are being explored currently, grouped under two strategies, both being hierarchical: (ra1) those using search strategies; (ra2) those strategizing a one-shot approach by which the model pose is directly estimated without searching. Based on 32 patient CT data sets each from the thorax and abdomen and 25 objects modeled, our analysis indicates that objects do not all scale uniformly with patient size. Even the simplest among the (ra2) strategies of recognizing the root object and then placing all other descendants as per the learned parent-to-offspring pose relationship bring the models on an average within about 18 mm of the true locations.
Fundamentals of Chemistry (1947)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Computation of mutual coupling between slot-coupled microstrip patches in a finite array (1992)

An analytical method is presented for the evaluation of mutual coupling between slot-coupled microstrip patches in a finite array. The approach is a combination of the equivalence principle and the reciprocity theorem and uses the spectral domain Green's functions for a dielectric slab in a moment method solution for the unknown patch and slot current distribution. The excitation mechanism of the patches is taken into account by introducing an N-port equivalent network, and the impedance matrix of an array of N-element slot-coupled patches is evaluated directly from its network voltage and current matrices of order N/sup 2/. As examples, the mutual impedances and scattering coefficients for two-, four-, and eight-element arrays are evaluated. Results are compared with measured data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
High-voltage nanosecond pulses in a low-pressure radio-frequency discharge (2013)

An influence of a high-voltage (3-17 kV) 20 ns pulse on a weakly-ionized low-pressure (0.1-10 Pa) capacitively coupled radiofrequency (RF) argon plasma is studied experimentally. The plasma evolution after pulse exhibits two characteristic regimes: a bright flash, occurring within 100 ns after the pulse (when the discharge emission increases by 2-3 orders of magnitude over the steady-state level), and a dark phase, lasting a few hundreds μs (when the intensity of the discharge emission drops significantly below the steady-state level). The electron density increases during the flash and remains very large at the dark phase. 1D3V particle-in-cell simulations qualitatively reproduce both regimes and allow for detailed analysis of the underlying mechanisms. It is found that the high-voltage nanosecond pulse is capable of removing a significant fraction of plasma electrons out of the discharge gap, and that the flash is the result of the excitation of gas atoms, triggered by residual electrons accelerated in the electric field of immobile bulk ions. The secondary emission from the electrodes due to vacuum UV radiation plays an important role at this stage. High-density plasma generated during the flash provides efficient screening of the RF field (which sustains the steady-state plasma). This leads to the electron cooling and, hence, onset of the dark phase.
The Effect of Proteolytic Enzymes on <i>E. coli</i> Phages and on Native Proteins (1964)

Lambda coli phage is not inactivated by chymotrypsin, trypsin, or ficin. T(2) phage is slowly inactivated by high concentrations of (alpha-, beta-, gamma-, or Delta-chymotrypsin, but not by trypsin or ficin. P(1) phage is slowly inactivated by alpha-, beta-, or gamma-chymotrypsin, or ficin, more rapidly by Delta-chymotrypsin, and much more rapidly by trypsin. Crystalline egg albumin, crystalline serum albumin, E. coli nucleoprotein, and yeast nucleoprotein are hydrolyzed slowly by alpha-chymotrypsin. Yeast nucleoprotein, like P(1) phage, is hydrolyzed more rapidly by Delta-chymotrypsin than by alpha-chymotrypsin, but not by trypsin or ficin. Neither phages nor native proteins were attacked by papain, carboxypeptidase, deoxyribonuclease, or ribonuclease.
Preconditioning for Edge-Preserving Image Super Resolution (2011)

We propose a simple preconditioning method for accelerating the solution of edge-preserving image super-resolution (SR) problems in which a linear shift-invariant point spread function is employed. Our technique involves reordering the high-resolution (HR) pixels in a similar manner to what is done in preconditioning methods for quadratic SR formulations. However, due to the edge preserving requirements, the Hessian matrix of the cost function varies during the minimization process. We develop an efficient update scheme for the preconditioner in order to cope with this situation. Unlike some other acceleration strategies that round the displacement values between the low-resolution (LR) images on the HR grid, the proposed method does not sacrifice the optimality of the observation model. In addition, we describe a technique for preconditioning SR problems involving rational magnification factors. The use of such factors is motivated in part by the fact that, under certain circumstances, optimal SR zooms are nonintegers. We show that, by reordering the pixels of the LR images, the structure of the problem to solve is modified in such a way that preconditioners based on circulant operators can be used.
Topological analysis and visualization of cyclical behavior in memory reference traces (2012)

We demonstrate the application of topological analysis techniques to the rather unexpected domain of software visualization. We collect a memory reference trace from a running program, recasting the linear flow of trace records as a high-dimensional point cloud in a metric space. We use topological persistence to automatically detect significant circular structures in the point cloud, which represent recurrent or cyclical runtime program behaviors. We visualize such recurrences using radial plots to display their time evolution, offering multi-scale visual insights, and detecting potential candidates for memory performance optimization. We then present several case studies to demonstrate some key insights obtained using our techniques.
Synthetic studies toward labionin, a new α,α‐disubstituted amino acid from type III lantibiotic labyrinthopeptin A2 (2011)

The labyrinthopeptins are a new class of lantibiotics containing two identical quaternary α,α-disubstituted amino acids, named labionin (Lab). The synthetic formation of this unique structural feature represents the key step in the total synthesis of these polycyclic peptides. In this report we describe the synthesis of an orthogonally protected α,α-disubstituted amino acid building block serving as labionin precursor for the future assembly of labyrinthopeptin A2 and of other labyrinthopeptin derivatives.
The synthesis of N 2,N 6-substituted diaminopurine ribosides (2007)

A series of new 2,6-substituted diaminopurine riboside derivatives were synthesized by activation of protected xantosine with sulfonyl chlorides followed by treatment with various amines. The relationship between the reactivity of intermediates and the nature of the activating agents was studied.
Chromosome Map of <i>Xanthomonas campestris</i> pv. campestris 17 with Locations of Genes Involved in Xanthan Gum Synthesis and Yellow Pigmentation (1999)

No plasmid was detected in Xanthomonas campestris pv. campestris 17, a strain of the causative agent of black rot in cruciferous plants isolated in Taiwan. Its chromosome was cut by PacI, PmeI, and SwaI into five, two, and six fragments, respectively, and a size of 4.8 Mb was estimated by summing the fragment lengths in these digests. Based on the data obtained from partial digestion and Southern hybridization using probes common to pairs of the overlapping fragments or prepared from linking fragments, a circular physical map bearing the PacI, PmeI, and SwaI sites was constructed for the X. campestris pv. campestris 17 chromosome. Locations of eight eps loci involved in exopolysaccharide (xanthan gum) synthesis, two rrn operons each possessing an unique I-CeuI site, one pig cluster required for yellow pigmentation, and nine auxotrophic markers were determined, using mutants isolated by mutagenesis with Tn5(pfm)CmKm. This transposon contains a polylinker with sites for several rare-cutting restriction endonucleases located between the chloramphenicol resistance and kanamycin resistance (Kmr) genes, which upon insertion introduced additional sites into the chromosome. The recA and tdh genes, with known sequences, were mapped by tagging with the polylinker-Kmr segment from Tn5(pfm)CmKm. This is the first map for X. campestris and would be useful for genetic studies of this and related Xanthomonas species.
Pore Characteristics and Their Effects on the Material Properties of Foamed Concrete Evaluated Using Micro-CT Images and Numerical Approaches (2017)

Foamed concrete contains numerous pores inside the material, and these pores are a significant factor determining the material characteristics. In particular, the pore distribution characteristics of foamed concrete significantly affect its thermal and mechanical properties. Therefore, an appropriate investigation is necessary for a more detailed understanding of foamed concrete. Here, a set of foamed concrete samples with different densities is used in order to investigate the density effects on the pore characteristics, as well as the physical properties of the materials. The pore distribution characteristics of these samples are investigated using an X-ray micro-computed tomography (micro-CT) imaging technique with probabilistic and quantitative methods. Using these methods, the anisotropy, the pore circularity factor and the relative density of cell thickness are examined. The thermal (thermal conductivity) and mechanical (directional modulus and strength) properties of each foamed specimen are computed using numerical simulations and compared with experimental results. From the obtained results, the effects of the pore sizes and shapes on the local and global properties of the foamed concrete are examined for developing advanced foamed concrete with lower thermal conductivity by minimizing the strength reduction.
Arginine and the Hofmeister Series: The Role of Ion–Ion Interactions in Protein Aggregation Suppression (2011)

l-Arginine hydrochloride is a very important aggregation suppressor for which there has been much attention given regarding elucidating its mechanism of action. Little consideration, however, has been given toward other salt forms besides chloride, even though the counterion likely imparts a large influence per the Hofmeister Series. Here, we report an in depth analysis of the role the counterion plays in the aggregation suppression behavior of arginine. Consistent with the empirical Hofmeister series, we found that the aggregation suppression ability of other arginine salt forms on a model protein (α-chymotrypsinogen) follows the order: H<sub>2</sub>PO<sub>4</sub><sup>–</sup> > SO<sub>4</sub><sup>2–</sup> > citrate<sup>2–</sup> > acetate<sup>–</sup> ≈ F<sup>–</sup> ≈ Cl<sup>–</sup> > Br<sup>–</sup> > I<sup>–</sup> ≈ SCN<sup>–</sup>. Mechanistically, preferential interaction and osmotic virial coefficient measurements, in addition to molecular dynamics simulations, indicate that attractive ion–ion interactions, particularly attractive interactions between arginine molecules, play a dominate role in the observed behavior. Furthermore, it appears that dihydrogen phosphate, sulfate, and citrate have strong attractive interactions with the guanidinium group of arginine, which seems to contribute to the superior aggregation suppression ability of those salt forms by bridging together multiple arginine molecules into clusters. These results not only further our understanding of how arginine influences protein stability, they also help to elucidate the mechanism behind the Hofmeister Series. This should help to improve biopharmaceutical stabilization through the use of other arginine salts and possibly, the development of novel excipients.
Synthesis and biochemical evaluation of N-(1-substituted-cycloalkyl)-beta-(3,4-dimethoxy; or dihydroxy) phenethylamines: potential dopaminergic agents. (1995)

The design and synthesis of some hybrid-structures comprising the dopamine framework on one hand and an N-(1-substituted-cycloalkyl) moiety on the other have been elaborated. Selective members of the new series were biochemically assayed to determine their effects on the levels of dopamine and its metabolite norepinephrine in brains of Albino-rats. The brain MAO activity was also estimated. The results were compared with those displayed by apomorphine, metoclopramide and PCP.
Discovery of Pectin-degrading Enzymes and Directed Evolution of a Novel Pectate Lyase for Processing Cotton Fabric (2004)

There is a growing need in the textile industry for more economical and environmentally responsible approaches to improve the scouring process as part of the pretreatment of cotton fabric. Enzymatic methods using pectin-degrading enzymes are potentially valuable candidates in this effort because they could reduce the amount of toxic alkaline chemicals currently used. Using high throughput screening of complex environmental DNA libraries more than 40 novel microbial pectate lyases were discovered, and their enzymatic properties were characterized. Several candidate enzymes were found that possessed pH optima and specific activities on pectic material in cotton fibers compatible with their use in the scouring process. However, none exhibited the desired temperature characteristics. Therefore, a candidate enzyme was selected for evolution. Using Gene Site Saturation Mutagenesistrade mark technology, 36 single site mutants exhibiting improved thermotolerance were produced. A combinatorial library derived from the 12 best performing single site mutants was then generated by using Gene Reassemblytrade mark technology. Nineteen variants with further improved thermotolerance were produced. These variants were tested for both improved thermotolerance and performance in the bioscouring application. The best performing variant (CO14) contained eight mutations and had a melting temperature 16 degrees C higher than the wild type enzyme while retaining the same specific activity at 50 degrees C. Optimal temperature of the evolved enzyme was 70 degrees C, which is 20 degrees C higher than the wild type. Scouring results obtained with the evolved enzyme were significantly better than the results obtained with chemical scouring, making it possible to replace the conventional and environmentally harmful chemical scouring process.