gebhart/patrepeval huggingface dataset:
TrustDavis: A non-exploitable online reputation system (2005)

We present TrustDavis, an online reputation system that provides insurance against trade fraud by leveraging existing relationships between players, such as the ones present in social networks. Using TrustDavis and a simple strategy, an honest player can set an upper bound on the losses caused by any malicious collusion of players. In addition, TrustDavis incents participants to accurately rate each other, resists participants' pseudonym changes, and is inherently distributed.
Physiologic and technical variables affecting hemodynamic measurements (1988)

Articles| March 01 1988 Physiologic and technical variables affecting hemodynamic measurements L Schermer L Schermer Search for other works by this author on: This Site PubMed Google Scholar Crit Care Nurse (1988) 8 (2): 33–40. https://doi.org/10.4037/ccn1988.8.2.33 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Cite Icon Cite Get Permissions Citation L Schermer; Physiologic and technical variables affecting hemodynamic measurements. Crit Care Nurse 1 March 1988; 8 (2): 33–40. doi: https://doi.org/10.4037/ccn1988.8.2.33 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCritical Care Nurse Search Advanced Search You do not currently have access to this content.
Blue-Green Diode Lasers (1994)

The development of compact, reliable and inexpensive short-wavelength lasers is certain to have profound effects on virtually any technology that uses coherent visible light. Although the impact of such devices will be far-reaching, the primary driving force behind efforts to develop blue-green diode lasers is without question optical recording. The demand for increased data storage capabilities is continually forcing the recording industry to increase storage densities.
Differences in the Pathological Changes in Dogs' Hearts After Defibrillation with Extrapericardial Paddles and Implanted Defibrillator Electrodes (1991)

A comparison was made between the pathological changes in the myocardium of eight dogs, each receiving about 90 joules of energy in a series of defibrillation discharges, delivered either between paddles placed against the pericardium (3 dogs) or between implanted Telectronics 040-105 defibrillation patch electrodes (5 dogs). The changes in the myocardium were most pronounced where the paddles had been applied to the pericardium. There was transmural damage beneath the left and right paddle positions and in the surrounding tissues. Extensive subepicardial and subendocardial myocyte damage was obvious histologically in the right ventricle of one of the patch dogs and in all of the paddle dogs. The percentage of damaged myocardial mass, both right ventricular and total involvement, was higher in the three paddle dogs compared with the five patch dogs. There was septal damage in the heart of one paddle dog. Necrosis of the right ventricular wall was observed in three of the patch dogs and in all the three paddle dogs. Scattered necrotic myocytes and some patches of mild necrosis up to 1-mm deep were observed in the left ventricle of the patch dogs (severity score 1-3). The necrosis was more extensive in the paddle dogs, ranging from mild necrosis less than 1-mm deep to marked necrosis incorporating half-to-whole ventricular wall thickness (severity score 3-5).
The Active Site His-460 of Human Acyl-coenzyme A:Cholesterol Acyltransferase 1 Resides in a Hitherto Undisclosed Transmembrane Domain (2005)

Human acyl-coenzyme A:cholesterol acyltransferase 1 (hACAT1) esterifies cholesterol at the endoplasmic reticulum (ER). We had previously reported that hACAT1 contains seven transmembrane domains (TMD) (Lin, S., Cheng, D., Liu, M. S., Chen, J., and Chang, T. Y. (1999) J. Biol. Chem. 274, 23276-23285) and nine cysteines. The Cys near the N-terminal is located at the cytoplasm; the two cysteines near the C-terminal form a disulfide bond and are located in the ER lumen. The other six free cysteines are located in buried region(s) of the enzyme (Guo, Z.-Y., Chang, C. C. Y., Lu, X., Chen, J., Li, B.-L., and Chang, T.-Y. (2005) Biochemistry 44, 6537-6548). In the current study, we show that the conserved His-460 is a key active site residue for hACAT1. We next performed Cys-scanning mutagenesis within the region of amino acids 354-493, expressed these mutants in Chinese hamster ovary cells lacking ACAT1, and prepared microsomes from transfected cells. The microsomes are either left intact or permeabilized with detergent. The accessibility of the engineered cysteines of microsomal hACAT1 to various maleimide derivatives, including mPEG(5000)-maleimide (large, hydrophilic, and membrane-impermeant), N-ethylmaleimide, 4-acetamido-4'-maleimidylstilbene-2,2'-disulfonic acid (small, hydrophilic, and ER membrane-permeant), and N-phenylmaleimide (small, hydrophobic, and ER membrane-permeant), were monitored by Western blot analysis. The results led us to construct a revised, nine-TMD model, with the active site His-460 located within a hitherto undisclosed transmembrane domain, between Arg-443 and Tyr-462.
Connectivity Learning in Multi-Branch Networks (2017)

While much of the work in the design of convolutional networks over the last five years has revolved around the empirical investigation of the importance of depth, filter sizes, and number of feature channels, recent studies have shown that branching, i.e., splitting the computation along parallel but distinct threads and then aggregating their outputs, represents a new promising dimension for significant improvements in performance. To combat the complexity of design choices in multi-branch architectures, prior work has adopted simple strategies, such as a fixed branching factor, the same input being fed to all parallel branches, and an additive combination of the outputs produced by all branches at aggregation points. In this work we remove these predefined choices and propose an algorithm to learn the connections between branches in the network. Instead of being chosen a priori by the human designer, the multi-branch connectivity is learned simultaneously with the weights of the network by optimizing a single loss function defined with respect to the end task. We demonstrate our approach on the problem of multi-class image classification using three different datasets where it yields consistently higher accuracy compared to the state-of-the-art "ResNeXt" multi-branch network given the same learning capacity.
Metallography (1984)

Metallography: Principles and Practice discusses metallographic techniques and their application to the study of metals, ceramics, and polymers. The book concentrates on techniques relevant to visual and light microscopy. Topics include macrostructure, specimen preparation for light microscopy, microstructure, light microscopy, hardness testing, and quantitative microscopy. An extensive collection of macrographs and micrographs is presented to illustrate the various methods discussed and to provide examples of their application to various materials. Appendices including etchants and specimen preparation procedures are included. For information on the print version, ISBN: 978-0-87170-672-0, follow this link.
Identification of a herpesvirus Saimiri cis-acting DNA fragment that permits stable replication of episomes in transformed T cells (1996)

Herpesvirus saimiri is a lymphotropic herpesvirus capable of immortalizing and transforming T cells both in vitro and in vivo. Immortalized and transformed T cells harbor several copies of the viral genome as a persisting genome. The mapping of the cis-acting genetic cis-acting segment (oriP) required for viral episomal maintenance is reported here. Viral DNA fragments that potentially contain oriP were cloned into a plasmid that contains the hygromycin resistance gene. After several round of subcloning followed by transfection, oriP was mapped to a 1.955-kb viral segment. This viral fragment permits stable plasmid replication without deletion or rearrangement as well as episomal maintenance without integration or recombination. The function of oriP depends on a trans-acting factor(s) encoded by the viral genome. The 1.955-kb viral segment includes a dyad symmetry region located between two small nuclear RNA genes and is located upstream of the dihydrofolate reductase gene homolog. Therefore, this oriP contains novel elements distinct from those of other DNA viruses.
Solid Phase Synthesis of Peptide C-Terminal Thioesters by Fmoc/<i>t</i>-Bu Chemistry (1999)

Peptide C-terminal thioesters are key intermediates in a variety of applications, most notably the recently developed native chemical ligation methods for the total chemical synthesis of proteins. So far they have been prepared only by the use of the least prevalent Boc/benzyl solid-phase method on ad hoc prepared resin supports. We describe here a novel method for the solid phase synthesis of thioesters by the most prevalent Fmoc/t-Bu method. The method is based on the use of a 3-carboxypropanesulfonamide safety-catch linker, which is fully stable to repetitive exposure to the basic conditions needed for Fmoc cleavage. Activation with diazomethane or iodoacetonitrile followed by displacement with a suitable thiol produces the thioester in good to excellent yields. The method is also compatible with Boc/benzyl chemistry. Moreover, all the necessary reagents are commercially available.
Combination Therapy of Insulin-Like Growth Factor Binding Protein-3 and Retinoid X Receptor Ligands Synergize on Prostate Cancer Cell Apoptosis <i>In vitro</i> and <i>In vivo</i> (2005)

We have previously identified the retinoid X receptor-alpha (RXRalpha) as an insulin-like growth factor binding protein-3 (IGFBP-3) nuclear binding partner, which is required for IGFBP-3-induced apoptosis. In the current study, we investigated the biological interactions of the RXR ligand, VTP194204 and rhIGFBP-3, in vitro and in vivo. In vitro, IGFBP-3 and VTP194204 individually induced apoptosis, and suppressed cell growth in prostate cancer cell lines in an additive manner. In vivo, LAPC-4 xenograft-bearing severe combined immunodeficiency mice treated daily with saline, IGFBP-3, and/or VTP194204 for 3 weeks showed no effect of individual treatments with IGFBP-3 or VTP194204 on tumor growth. However, the combination of IGFBP-3 and VTP194204 treatments inhibited tumor growth by 50% and induced a significant reduction in serum prostate-specific antigen levels. In terminal nucleotidyl transferase-mediated nick end labeling immunohistochemistry of LAPC-4 xenografts, there was modest induction of apoptosis with either IGFBP-3 or VTP194204 individual treatment, but combination therapy resulted in massive cell death, indicating that IGFBP-3 and VTP194204 have a synergistic effect in preventing tumor growth by apoptosis induction. In summary, this is an initial description of the successful therapeutic use of IGFBP-3 as a cancer therapy in vivo, and shows that combination treatment of IGFBP-3 and RXR ligand has a synergistic effect on apoptosis induction leading to substantial inhibition of prostate cancer xenograft growth. Taken together, these observations suggest that combination therapy with IGFBP-3 and RXR ligands may have therapeutic potential for prostate cancer treatment.
Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (III) Clinical responses of early-postmenopausal women to Maca in double blind, randomized, Placebo-controlled, crossover configuration, outpatient study. (2006)

This is the second, conclusive part of the clinical study on clinical responses of early-postmenopausal women to standardized doses of pre-Gelatinized Organic Maca (Maca-GO). Total of 34 Caucasian women volunteers participated in a double-blind, randomized, four months outpatient crossover configuration Trial. After fulfilling the criteria of being early-postmenopausal: blood Estrogen (E2<40 pg/ml) and Follicle Stimulating Hormone (FSH>30 IU/ml) at admission, they were randomly allocated to Placebo (P) and Maca-GO (M) treatments (2 groups of 11 participants each). Two 500 mg vegetable hard gel capsules with Maca-GO or Placebo powder were self-administered twice daily with meals (total 2 g/day). At admission and follow-up monthly intervals, body mass index (BMI), blood pressure, levels of gonadal, pituitary, thyroid and adrenal hormones, lipids and key minerals were measured. Bone markers were determined after four months M and P use in 12 participants. Menopausal symptoms were assessed according to Greene's Score (GMS) and Kupperman's Index (KMI). Data were analyzed using multivariate technique on blocs of monthly. Results and canonical variate technique was applied to GMS and KMI matrices. Two months application of Maca-GO stimulated (P<0.05) production of E2, suppressed (P<0.05) blood FSH, Thyroid (T3) and Adrenocorticotropic hormones, Cortisol, and BMI, increased (P<0.05) low density lipoproteins, blood Iron and alleviated (P<0.001) menopausal symptoms. Maca-GO noticeably increased bone density markers. In conclusion, Maca-GO applied to early-postmenopausal women (i) acted as a toner of hormonal processes along the Hypothalamus-Pituitary-Ovarian axis, (ii) balanced hormone levels and (iii) relieved symptoms of menopausal discomfort, (hot flushes and night sweating in particular), thus, (iv) exhibited a distinctive function peculiar to adaptogens, providing an alternative non-hormonal plant option to reduce dependence on hormone therapy programs (HRT).
Bleeding rates necessary for detecting acute gastrointestinal bleeding with technetium-99m-labeled red blood cells in an experimental model. (1987)

Proponents of [99mTc]sulfur colloid for GI bleeding studies argue that, although labeled red blood cells are useful for intermittent bleeding, they are not capable of detecting low bleeding rates. Studies of dogs with experimental GI bleeding have indicated bleeding rates of 0.05 ml/min can be detected with [99mTc]sulfur colloid. Since similar data in the dog model were unavailable for 99mTc-labeled red blood cells, we undertook this study. To simulate lower GI bleeding, catheters were inserted into the bowel lumen. Each dog's blood was labeled with 99mTc using an in vitro technique. Venous blood was then withdrawn and re-infused into the lumen of the bowel using a Harvard pump. Fourteen dogs were studied, ten receiving a bleeding rate from 4.6-0.02 ml/min in the descending colon and four with proximal jejunal bleeds of 0.20-0.02 ml/min. Bleeding rates of 4.6-0.2 ml/min were detected within 10 min in the colon and bleeding rates as low as 0.04 ml/min were seen by 55 min. Slower bleeding rates were not detected. Similar findings were noted for proximal jejunal bleeds. Based on the time of appearance, a minimum volume of approximately 2-3 ml labeled blood was necessary to detect bleeding. We conclude that 99mTc-labeled RBCs are sensitive for low bleeding rates in the dog model. The rates are comparable to those described for [99mTc]sulfur colloid in this experimental setting. The time of appearance of activity is related to the bleeding rate.
Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons (2013)

Lim ASP; Kowgier M; Yu L; Buchman AS; Bennett DA. Sleep fragmentation and the risk of incident alzheimer's disease and cognitive decline in older persons. <i>SLEEP</i> 2013;36(7):1027-1032.
Recursive Algorithms for Computing End-to-End Blocking in a Network with Arbitrary Routing Plan (1980)

This paper presents three recursive algorithms for computing end-to-end blocking probabilities in a network with alternate routing, based on link blocking probabilities. The only assumption made is the statistical independence of link blocking probabilities. The first algorithm applies to arbitrary routing plans. The second algorithm applies to single-loss-route routing plans which include predictive routing plans used in advanced private networks. The second algorithm is also applicable to solving the terminal-pair reliability problem. The third algorithm applies to tandem-node-matrix-generated routing plans which include hierarchical routing plans similar to those used in North American public toll network, AT&T's CCSA, EPSCS, and ETN networks. These three algorithms are progressively more efficient.
Digitally controlled synchronous bridge-rectifier for wireless power receivers (2013)

Reducing power loss in wireless power receivers is important to avoid thermal design issues. Synchronous rectification is a suitable means for loss reduction. In this paper we propose a synchronous rectifier with a simple control scheme. A detailed analysis leads to a time-domain model which is used to perform a power loss analysis. Experimental verification shows that the predicted efficiency improvement agrees with measurement results.
Genomic Exploration of the Hemiascomycetous Yeasts: 15. <i>Pichia sorbitophila</i> (2000)

This paper reports the genomic analysis of the strain CBS7064 of Pichia sorbitophila, a homothallic diploid yeast. We sequenced 4829 random sequence tags of about 1 kb and compared them to the Saccharomyces cerevisiae gene products. Approximately 1300 nuclear genes, 22 tRNAs, the rDNA locus, and six mitochondrial genes have been identified. The analysis of the rDNA genes has permitted to classify this organism close to the Candida species. Accession numbers from AL414896 to AL419724 at EMBL databank.
Issues in realization of an execution time analyzer for distributed real-time objects (2002)

An issue that the real-time software research community has long recognized as an important technological challenge but has not shown much progress in meeting the challenge is to guarantee response times of real-time distributed systems. Two basic problems must be addressed to effectively meet this challenge: establishment of the distributed real-time program structure and the system infrastructure structure that enable systematic analysis of the worst-case time behavior of the application systems; and development of tools which perform automated analysis of the worst-case time behavior while leaving only minimal work to the designers. Research on the first problems has produced some useful results in recent years. Time is thus ripe for tackling the second problem on the basis of those recent developments in handling the first problem. This paper describes a desirable systematic timing analysis process which builds upon the recent results in the first problem area. An outline of a desirable analysis tool is also presented.
Energy-Efficient Nonvolatile Reconfigurable Logic using Spin Hall Effect-based Lookup Tables (2016)

In this paper, we leverage magnetic tunnel junction (MTJ) devices to design an energy-efficient nonvolatile lookup table (LUT), which utilizes a spin Hall effect (SHE) assisted switching approach for MTJ storage cells. SHE-MTJ characteristics are modeled in Verilog-A based on precise physical equations. Functionality of the proposed SHE-MTJ-based LUT is validated using SPICE simulation. Our proposed SHE-MTJ-based LUT (SHE-LUT) is compared with the most energy-efficient MTJ-based LUT circuits. The obtained results show more than 6%, 37%, and 67% improvement over three previous MTJ-based designs in term of read energy consumption. Moreover, the reconfiguration delay and energy of the proposed design is compared with that of the MTJ-based LUTs which utilize the spin transfer torque (STT) switching approach for reconfiguration. The results exhibit that SHE-LUT can operate at 78% higher clock frequency while achieving at least 21% improvement in terms of reconfiguration energy consumption. The operation-specific clocking mechanisms for managing the SHE-LUT operations are introduced along with detailed analyses concerning tradeoffs. Results are extended to design a 6-input fracturable LUT using SHE-MTJs.
Short Therapeutic Window for MK-801 in Transient Focal Cerebral Ischemia in Normotensive Rats (1996)

The present study investigates the role of N-methyl-D-aspartate (NMDA) receptors in a model of transient focal cerebral ischemia in normotensive rats. The left middle cerebral artery and both common carotid arteries were occluded for 60 min. Preliminary studies indicated that this gave reproducible infarctions of the cortex and striatum. These infarctions were the result of severe ischemia followed by complete reperfusion after clamp removal, as showed by striatal tissue Po2 monitoring. Microdialysis indicated that glutamate concentration increased immediately after occlusion and returned to the baseline value 40 min after clamp removal. MK-801 (1 mg kg-1 i.v.), an antagonist of the NMDA glutamatergic receptor, reduced the cortical infarct volume by 29% (p < 0.001) and the striatal infarct volume by 14% (p < 0.05) when given just prior to ischemia, but had no neuroprotective activity when given 30 min after the onset of ischemia. This short therapeutic window for MK-801 suggests that NMDA receptors play only a transient role in reversible focal ischemia in rats.
Pseudo-recurrent Connectionist Networks: An Approach to the 'Sensitivity-Stability' Dilemma (1997)

In order to solve the 'sensitivity-stability' problem-and its immediate correlate, the problem of sequential learning-it is crucial to develop connectionist architectures that are simultaneously sensitive to, but not excessively disrupted by, new input. French (1992) suggested that to alleviate a particularly severe form of this disruption, catastrophic forgetting, it was necessary for networks to separate dynamically their internal representations during learning. McClelland et al. (1995) went even further. They suggested that nature's way of implementing this obligatory separation was the evolution of two separate areas of the brain, the hippocampus and the neocortex. In keeping with this idea of radical separation, a 'pseudo-recurrent' memory model is presented here that partitions a connectionist network into two functionally distinct, but continually interacting areas. One area serves as a final-storage area for representations; the other is an early-processing area where new representations are first learned by the system. The final-storage area continually supplies internally generated patterns (pseudopatterns; Robins, 1995), which are approximations of its content, to the early-processing area, where they are interleaved with the new patterns to be learned. Transfer of the new learning is done either by weight-copying from the early-processing area to the final-storage area or by pseudopattern transfer. A number of experiments are presented that demonstrate the effectiveness of this approach, allowing, in particular, effective sequential learning with gradual forgetting in the presence of new input. Finally, it is shown that the two interacting areas automatically produce representational compaction and it is suggested that similar representational streamlining may exist in the brain.
Engineering Web applications for reuse (2001)

Web design frameworks combine generic conceptual, navigational, and context schemas. Such frameworks offer developers a conceptual approach to maximize design reuse rather than code reuse in Web applications. The authors apply the object oriented hypermedia design extension, OOHDM-Frame, to determine key architectural components and design structures that lend themselves to reuse.