gebhart/patrepeval huggingface dataset:
Physicochemical characterization of the androgen receptor from hyperplastic human prostate (1984)

Abstract In this manuscript we have characterized the androgen receptor from human benign prostatic hypertrophied (BPH) tissue. BPH tissue was obtained fresh from surgery, ground, and frozen in liquid nitrogen. Tissue was homogenized in 10 mM Tes buffer (pH 7.4 at 25°C) containing 0.25 M sucrose, 20 mM Na 2 MoO 4 , 12 mM monothioglycerol, and 1.5 mM EDTA. Cytosol was labeled with ( 3 H)‐R1881 (0.5–10 nM) ± a 100‐fold excess of R1881 and a 500‐fold excess of triamcinolone acetonide to identify specific androgen receptor sites. An exchange assay was developed, whereby maximum binding was achieved by raising the temperature to 30°C for 15 min. A high‐affinity binding protein was detected (Kd = 1.3 ± 0.8 nM) which had a binding capacity of 15 ± 7 fmol/mg protein. Binding was specific for androgens with the following Ki (nM) values: R1881 (0.09), dihydrotestosterone (6), testosterone (50), progesterone (92), estradiol (100), epitestosterone (860), and cortisol (> 1,000). Under high ionic conditions the sedimentation coefficient of the receptor was 4.1 S. Higher S values were not observed in the presence of the following protein inhibitors: leupeptin (20 or 150 μM), iodoacetamide (10 mM), DFP (5 mM), PMSF (1 mM), bacitracin (0.1 mM), antipain (0.1 mM), aprotinin (1 TIU/ml). Gel filtration analysis revealed a Stokes radius of 6.5 nm. These data indicate a M r of 120,000 and a f/fo of 2.01. The receptor eluted from a chromatofocusing column at a pH of 6.8. The receptor bound to phosphocellulose and DNA cellulose after being heat‐treated for 15 min at 30°C. These results suggest that BPH tissue contains an androgen receptor which is similar to receptors in other androgen‐responsive tissues.
Reviews of Books (1988)

Journal Article Reviews of Books Get access The Origins of War in Early Modern Europe. Edited by Jeremy Black. Edinburgh: John Donald. 1987. xiii + 271 pp. £20.00. ISBN 0-85976-168-1 H. M SCOTT H. M SCOTT University of St Andrews Search for other works by this author on: Oxford Academic Google Scholar French History, Volume 2, Issue 3, September 1988, Pages 353–354, https://doi.org/10.1093/fh/2.3.353 Published: 01 September 1988
Hexafluoroisopropoxy-containing polyacrylates (1993)

The fluorinated alcohol, 4-fluoro(2-hydroxyhexafluoroisopropyl)benzene (HFIPFB) has proven to be an highly useful starting material for the preparation of various fluorinated acrylic polymers. Hexafluoroisopropoxy-containing acrylic monomers were prepared from the acid derivative of HFIPFB and hydroxyalkyl methacrylate. These monomers were characterized by IR, NMR and elemental analysis. The homo- and copolymerizations of these monomers and nonfluorinated analogues were effected by radical polymerization to yield fluoro-acrylic polymers which were soluble in common organic solvents such as CHCl{sub 3} and THF. The inherent viscosity of these polymers ranged up to 1.5 dL/g.
Construction and Function of Two Cys146-Mutants with High Activity, Derived from Recombinant Human Soluble B Lymphocyte Stimulator (2004)

B lymphocyte stimulator (BLyS) is a novel member of tumor necrosis factor (TNF) ligand family that is important in B cell maturation and survival. Previous studies were almost related to the function or mechanism of its wild type. Here, we constructed two site-directed mutants of the recombinant human soluble BLyS, the BY-A and BY-V, and found that BY-V ranked the highest whenever in the process of promoting proliferation of B lymphocytes in vitro or stimulating total serum IgG and IgM secretion in vivo. Besides, assays for the biological responses of human leukemic cell lines to BLyS, BY-A and BY-V demonstrated that they could suppress the proliferation of Raji cells but promote the growth of THP-1. The discovery of BY-V with high activity will help come to a conclusion that the mutation of Cys146 to Val146 might improve the biological activity of BLyS.
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation (2004)

Rat LC3, a homologue of yeast Atg8 (Aut7/Apg8), localizes to autophagosomal membranes after post-translational modifications. The C-terminal fragment of LC3 is cleaved immediately following synthesis to yield a cytosolic form called LC3-I. A subpopulation of LC3-I is further converted to an autophagosome-associating form, LC3-II. Because yeast Atg8 is conjugated with phosphatidylethanolamine (PE) by a ubiquitin-like system, it has been hypothesized that LC3 is modified in a similar manner. Here, we show that [(14)C]-ethanolamine was preferentially incorporated into LC3-II, suggesting that LC3-II is a PE-conjugated form. LC3-II can be a substrate of mammalian Atg4B, a homologue of yeast Atg8-PE deconjugase, supporting the idea that LC3-II is LC3-PE. Moreover, two other mammalian homologues of yeast Atg8, gamma-aminobutyric-acid-type-A-receptor-associated protein (GABARAP) and Golgi-associated ATPase enhancer of 16 kDa (GATE16) also generate form II, which are recovered in membrane fractions. Generation of the form II correlates with autophagosome association of GABARAP and GATE16. These results suggest that all mammalian Atg8 homologues receive a common modification to associate with autophagosomal membrane as the form II.
Fast Reactor Subassembly Design Modifications for Increasing Electricity Generation Efficiency (2009)

Suggested for Track 7: Advances in Reactor Core Design and In-Core Management _____________________________________________________________________________________ Fast Reactor Subassembly Design Modifications for Increasing Electricity Generation Efficiency R. Wigeland and K. Hamman Idaho National Laboratory Given the ability of fast reactors to effectively transmute the transuranic elements as are present in spent nuclear fuel, fast reactors are being considered as one element of future nuclear power systems to enable continued use and growth of nuclear power by limiting high-level waste generation. However, a key issue for fast reactors is higher electricity cost relative to other forms of nuclear energy generation. The economics of the fast reactor are affected by the amount of electric power that can be produced from a reactor, i.e., the thermal efficiency for electricity generation. The present study is examining the potential for fast reactor subassembly design changes to improve the thermal efficiency by increasing the average coolant outlet temperature without increasing peak temperatures within the subassembly, i.e., to make better use of current technology. Sodium-cooled fast reactors operate at temperatures far below the coolant boiling point, so that the maximum coolant outlet temperature is limited by the acceptable peak temperatures for the reactor fuel and cladding. Fast reactor fuel subassemblies have historically been constructed using a large number of small diameter fuel pins contained within a tube of hexagonal cross-section, or hexcan. Due to this design, there is a larger coolant flow area next to the hexcan wall as compared to flow area in the interior of the subassembly. This results in a higher flow rate near the hexcan wall, overcooling the fuel pins next to the wall, and a non-uniform coolant temperature distribution. It has been recognized for many years that this difference in sodium coolant temperature was detrimental to achieving greater thermal efficiency, since it causes the fuel pins in the center of the subassembly to operate at higher temperatures than those near the hexcan walls, and it is the temperature limit(s) for those fuel pins that limits the average coolant outlet temperature. Fuel subassembly design changes are being investigated using computational fluid dynamics (CFD) to quantify the effect that the design changes have on reducing the intra-subassembly coolant flow and temperature distribution. Simulations have been performed for a 19-pin test subassembly geometry using typical fuel pin diameters and wire wrap spacers. The results have shown that it may be possible to increase the average coolant outlet temperature by 20 C or more without changing the peak temperatures within the subassembly. These design changes should also be effective for reactor designs using subassemblies with larger numbers of fuel pins. R. Wigeland, Idaho National Laboratory, P.O. Box 1625, Mail Stop 3860, Idaho Falls, ID, U.S.A., 83415-3860 email – roald.wigeland@inl.gov fax (U.S.) – 208-526-2930
BATVI: Fast, sensitive and accurate detection of virus integrations (2017)

We compared the performance of BatVI with existing methods VirusFinder and VirusSeq using both simulated and real-life datasets of liver cancer patients. BatVI ran an order of magnitude faster and was able to predict almost twice the number of true positives compared to other methods while maintaining a false positive rate less than 1%. For the liver cancer datasets, BatVI uncovered novel integrations to two important genes TERT and MLL4, which were missed by previous studies. Through gene expression data, we verified the correctness of these additional integrations. BatVI can be downloaded from http://biogpu.ddns.comp.nus.edu.sg/~ksung/batvi/index.html .
In Situ Evaluation of Nanoparticle–Protein Interactions by Dynamic Magnetic Susceptibility Measurements (2013)

The use of dynamic magnetic susceptibility measurements is reported to study nanoparticle–protein interactions in situ. The technique consists of measuring the rotational diffusivity of thermally blocked magnetic nanoparticles (MNPs) in protein solutions. To illustrate the technique, the effect of nanoparticle zeta potential in carboxymethyl‐dextran‐coated MNPs and their interaction with model anionic and cationic proteins, such as bovine serum albumin (BSA), immunoglobulin G (IgG), fibrinogen (FIBR), apo‐transferrin (TRANS), lysozyme (LYZ), and histone (HIS), in a range of protein concentrations is studied. Experiments indicate that interactions between the negatively charged particles and the negatively charged proteins BSA, IgG, FIBR, and TRANS are negligible. However, positively charged proteins LYZ and HIS readily absorb onto the nanoparticles, as evidenced by an increase in size and eventual aggregation of the particles. Onset of this effect seems to happen at a lower concentration of HIS compared with LYZ. The technique could be applied to other particle surface coatings and to particles in complex protein mixtures, such as whole blood and serum, allowing systematic in situ studies of nanoparticle–protein interactions.
Synthesis of poly(vinyl ether)-based, ABA triblock-type thermoplastic elastomers with functionalized soft segments and their gas permeability (2015)

The ABA-type triblock copolymers consisting of poly(2-adamantyl vinyl ether) [poly(2-AdVE)] as outer hard segments and poly(6-acetoxyhexyl vinyl ether) [poly(AcHVE)], poly(6-hydroxyhexyl vinyl ether) [poly(HHVE)], or poly(2-(2-methoxyethoxy)ethyl vinyl ether) [poly(MOEOVE)] as inner soft segments were synthesized by sequential living cationic polymerization. Despite the presence of polar functional groups such as ester, hydroxyl, and oxyethylene units in their soft segments, the block copolymers formed elastomeric films. The thermal and mechanical properties and morphology of the block copolymers showed that the two polymer segments of these triblock copolymers were segregated into microphase-separated structure. Effect of the functional groups in the soft segments on gas permeability was investigated as one of the characteristics of the new functional thermoplastic elastomers composed solely of poly(vinyl ether) backbones. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 1114–1124
DIABETIC DELAYED WOUND HEALING AND THE ROLE OF SILVER NANOPARTICLES (2008)

Diabetes mellitus is most common disease of the altered glucose homeostasis. Diabetics have impaired wound healing and impaired formation of coronary collaterals. The abnormal apoptosis or angiogenesis may cause many of the clinical manifestations of diabetes. Silver has been known to have effective bactericidal properties for centuries. Nowadays, silver-based topical dressings have been widely used as a treatment for infections in burns, open wounds, and chronic ulcers. Silver nanoparticles are novel nanosized and highly crystalline antibacterial agent which carries Ag + ions by ionexchanging. This review is an attempt to illustrate the molecular signaling of the apoptosis involved in delayed wound healing and the role of silver nanoparticles in earlier healing.
Tumor Location Detected with Radioactively Labeled Monoclonal Antibody and External Scintigraphy (1979)

Murine teratocarcinomas were located in mice by external gamma-ray scintigraphy with an iodine-125-labeled monoclonal antibody specific to the tumors. The specificity of the method was increased by subtracting the radiation produced by an iodine-125-labeled indifferent monoclonal antibody of the same immunoglobulin class as the tumor-specific antibody.
Inductively coupled plasma-mass spectrometric method for the determination of dissolved trace elements in natural water (1996)

An inductively coupled plasma-mass spectrometry method was developed for the determination of dissolved Al, As, B, Ba, Be, Cd, Co, Cr, Cu, Li, Mn, Mo, Ni, Pb, Sr, Tl, U, V, and Zn in natural waters. Detection limits are generally in the 50-100 picogram per milliliter (pg/mL) range, with the exception of As which is in the 1 microgram per liter (ug/L) range. Interferences associated with spectral overlap from concomitant isotopes or molecular ions and sample matrix composition have been identified. Procedures for interference correction and reduction related to isotope selection, instrumental operating conditions, and mathematical data processing techniques are described. Internal standards are used to minimize instrumental drift. The average analytical precision attainable for 5 times the detection limit is about 16 percent. The accuracy of the method was tested using a series of U.S. Geological Survey Standard Reference Water Standards (SWRS), National Research Council Canada Riverine Water Standard, and National Institute of Standards and Technology (NIST) Trace Elements in Water Standards. Average accuracies range from 90 to 110 percent of the published mean values.
Pd/δ-Al<sub>2</sub>O<sub>3</sub> Catalysts for Isoprene Selective Hydrogenation:  Regeneration of Water-Poisoned Catalysts (1997)

Water-containing isoprene was partial hydrogenated over δ-alumina-supported eggshell Pd catalysts with a weight-hourly space velocity (WHSV) of 18 h-1 (grams of feed per hour × grams of catalyst) at 40 °C and 30 atm (30.39 kg/cm2) total pressure. The isoprene conversion decreased with time on stream and became almost time invariant at about 50 h, with a value of 20%. The activity of the water-poisoned catalysts was only slightly recovered after the water-free isoprene was introduced; by this, the conversion was increased only to 24%. In contrast, by hydrogen treatment prior to the introduction of water-free feed, the water-poisoned catalyst was greatly reactivated. The improvement in activity was also influenced by temperature. The number of Pd sites available for CO chemisorption was increased and, thus, the catalyst activity was improved by a raise in temperature to 200 °C, then declined. At nearly steady state, the isoprene conversion by catalysts reactivated at 200 °C is about 93% of that by catalysts without water-poisoning. The loss of the catalyst activity was thought to be caused by the Pd agglomeration during hydrogen reactivation. EXAFS (extended X-ray absorption fine structure) spectroscopy results indicated that the average Pd−Pd coordination number increased from 6.4 to 8.3 after reactivation of the catalyst with hydrogen at 400 °C.
Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects (2012)

This study demonstrated that ceftolozane penetrated well into the ELF following parenteral administration of ceftolozane/tazobactam.
N-Lysine Propionylation Controls the Activity of Propionyl-CoA Synthetase (2007)

Reversible protein acetylation is a ubiquitous means for the rapid control of diverse cellular processes. Acetyltransferase enzymes transfer the acetyl group from acetyl-CoA to lysine residues, while deacetylase enzymes catalyze removal of the acetyl group by hydrolysis or by an NAD(+)-dependent reaction. Propionyl-coenzyme A (CoA), like acetyl-CoA, is a high energy product of fatty acid metabolism and is produced through a similar chemical reaction. Because acetyl-CoA is the donor molecule for protein acetylation, we investigated whether proteins can be propionylated in vivo, using propionyl-CoA as the donor molecule. We report that the Salmonella enterica propionyl-CoA synthetase enzyme PrpE is propionylated in vivo at lysine 592; propionylation inactivates PrpE. The propionyl-lysine modification is introduced by bacterial Gcn-5-related N-acetyltransferase enzymes and can be removed by bacterial and human Sir2 enzymes (sirtuins). Like the sirtuin deacetylation reaction, sirtuin-catalyzed depropionylation is NAD(+)-dependent and produces a byproduct, O-propionyl ADP-ribose, analogous to the O-acetyl ADP-ribose sirtuin product of deacetylation. Only a subset of the human sirtuins with deacetylase activity could also depropionylate substrate. The regulation of cellular propionyl-CoA by propionylation of PrpE parallels regulation of acetyl-CoA by acetylation of acetyl-CoA synthetase and raises the possibility that propionylation may serve as a regulatory modification in higher organisms.
QoS as middleware: bandwidth reservation system design (2003)

We wish to provide quality of service (QoS) to scientists who are remotely controlling experiments on singular instruments such as the LBL Advanced Light Source (ALS) or who need to harness heterogeneous and distributed computing resources to perform large-scale computation. To ensure the timely availability of the computing, storage, and networking resources required for data collection and/or analysis, use of these resources must be scheduled in advance. The bandwidth reservation system (BRS) reserves time in IP differentiated service classes (S. Blake et al.). These classes have upper bounds on the total bandwidth allocation. The reservation unit is a slot: a well-defined period of time with an associated bandwidth. The sum of the allocated bandwidths in all of the slot allocations never exceeds the maximum bandwidth defined for the service class. The result is that the classes are never oversubscribed.
Quantitative measurements of water concentration of the stratum corneum in vivo by high-frequency current. (1994)

The superficial portion of the stratum corneum (SC), which is always under the influence of various exogenous factors, easily develops firm and brittle skin surface changes, whenever its hydration state is reduced or whenever there is any functionally deficient area of pathological SC that is unable to retain enough water even in the usual ambient conditions. In contrast, the deeper portion of the SC, which is always well hydrated because of its structural closeness to fully water-saturated viable epidermis, does not pose any serious problems as long as the skin is normal. Based on in vivo and in vitro measurements we have established that high-frequency conductance is a non-invasive technique which measures the hydration state of the superficial portion of the SC, the crucial part determining the physical properties of the skin surface.
The Whirlwind I computer (1951)

Project Whirlwind is a high-speed computer activity sponsored at the Digital Computer Laboratory, formerly a part of the Servomechanisms Laboratory, of the Massachusetts Institute of Technology (M.I.T.) by the Office of Naval Research (O.N.R.) and the United States Air Force. The project began in 1945 with the assignment of building a high-quality real-time aircraft simulator. Historically, the project has always been primarily interested in the fields of real-time simulation and control; but since about the beginning of 1947 most of its efforts have been devoted to the design and construction of the digital computer known as Whirlwind I (WWI). This computer has been in operation for about 1 year and an increasing proportion of project effort now is going into application studies.
A 1.4‐Gbps intra‐panel interface with low‐power and low‐EMI schemes for Tablet PC applications (2012)

Abstract An intra‐panel interface addressing all of the high‐speed, low‐power, and low‐electromagnetic interference (EMI) requirements for tablet personal computer applications is presented. This work proposes an adaptive clock window scheme to achieve 1.4‐Gbps data‐rate. For EMI suppression, data scrambling, horizontal blank period pattern scrambling, and novel clock and data recovery circuit are introduced. Lastly, for power‐saving, the proposed interface dynamically biases source driver's output buffers and employs early charge sharing by controlling the configuration data. For verification, a WQXGA thin‐film transistor liquid crystal display system is implemented with the timing controller and source driver ICs that are fabricated using 65‐nm and 180‐nm complementary metal‐oxide semiconductor (CMOS) processes, respectively. The liquid crystal display system demonstrates maximum operation speed of 1.4 Gbps and suppression of EMI noise in LTE Band‐20 and GSM 850 bands. The proposed power‐saving schemes achieve 4.3% reduction in total power consumption by source driver IC, which reaches about 85% of power consumption by enhanced reduced‐voltage differential signaling interface circuit.
The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial (2014)

This is the first evaluation of the efficacy for a course of oxytocin treatment for youth with ASD. Although results did not suggest clinical efficacy, further research is needed to explore alternative delivery methods, earlier age of intervention, and the influence of caregiver expectation on treatment response.
NEUBAU DER DONAUBRUECKE SAAL BEI KELHEIM (1996)

Die Bruecke entstand im Zuge einer ca. 3 km langen Ortsumgehung zur Entlastung der Ortsdurchfahrt Kelheim und zum besseren Anschluss des Altmuehltals an das ueberregionale Strassennetz und an den Hafen Kelheim. Die 486 m lange Spannbetonbruecke ueberspannt mit 9 Feldern die Vorlandbereiche, die Donau sowie ein Altwasser. Die groesste Stuetzweite betraegt 95 m. Die je drei Felder der Vorlandbruecken wurden abschnittsweise auf einem Lehrgeruest hergestellt. Die drei mittleren Felder im Strombereich dagegen im Freivorbau von den beiden Flusspfeilern aus. Der Querschnitt des Ueberbaus ist ein einzelliger Kastentraeger. Die Bauhoehe betraegt in den Vorlandbereichen 2,40 m. In Richtung der Stompfeiler nimmt sie parabelfoermig auf 4,85 m zu. Die Brueckenbreite betraegt 14,00 m. Davon entfallen 8,00 m auf die Fahrbahn und 2,00 m beziehungsweise 4,00 m auf seitliche Randkappen. Als Vorspannung kamen Litzenspannglieder zur Anwendung. Die Flusspfeiler konnten flach auf Fels im Schutze von Spundwandkaesten gegruendet werden. Die Widerlager und alle anderen Pfeiler - bis auf zwei - wurden dagegen auf Grossbohrpfaehlen gegruendet. Die Durchfuehrung der Bauarbeiten sowie konstruktive Einzelheiten werden beschrieben.
Terahertz spectral database for expanding applications (2009)

NICT and Riken have established an online terahertz spectral database with more than 500 spectra, in September 2008. Increasing interests in terahertz spectroscopy from industries requires more spectra in various research fields. This paper introduces the database to encourage participation from around the globe.