gebhart/patrepeval huggingface dataset:
Basic Residues in Azurocidin/HBP Contribute to Both Heparin Binding and Antimicrobial Activity (2002)

Azurocidin/CAP37/HBP is an antimicrobial and chemotactic protein that is part of the innate defenses of human neutrophils. In addition, azurocidin is an inactive serine protease homolog with binding sites for diverse ligands including heparin and the bovine pancreatic trypsin inhibitor (BPTI). The structure of the protein reveals a highly cationic domain concentrated on one side of the molecule and responsible for its strong polarity. To investigate the role of this highly basic region, we produced three recombinant azurocidin mutant proteins that were altered in either one or both of two clusters of 4 basic residues located symmetrically on each side of a central cleft in the cationic domain. Two of the mutant proteins (Loop 3: R5Q, K6Q, R8Q, and R10Q; Loop 4: R61Q, R62Q, R63Q, and R65Q) exhibited little or no change in heparin and BPTI binding or in antimicrobial function. In contrast, the Loop 3/Loop 4 mutant (R5Q, K6Q, R8Q, R10Q, R61Q, R62Q, R63Q, and R65Q) in which all 8 basic residues were replaced showed greatly decreased ability to bind heparin and to kill Escherichia coli and Candida albicans. Thus, we report that the 8 basic residues that were altered in the Loop 3/Loop 4 mutant contribute to the ability of the wild-type azurocidin molecule to bind heparin and to kill E. coli and C. albicans. Because BPTI binding was comparable in wild-type and Loop 3/Loop 4 mutant protein, we conclude that the same 8 basic residues are not involved in the binding of BPTI to azurocidin, supporting the notion that the binding site for BPTI is distinct from the site involved in heparin binding and antimicrobial activity. Finally, we show that removal of all 4 positively charged amino acids in the 20-44 azurocidin sequence (DMC1: R23Q,H24S,H32S,R34Q), a region previously thought to contain an antimicrobial domain, does not affect the activity of the protein against E. coli, Streptococcus faecalis, and C. albicans.
Radiation effects on fluorinated field oxides and associated devices (1990)

Fluorine has been introduced into the LOCOS field oxide by high-energy (2-MeV) F implantation and subsequent annealing at 950 degrees C for 60 min. Improved radiation hardness of the field oxide and its associated device parameters was observed. N-channel MOSFETs isolated by the fluorinated oxide exhibit a lower radiation-induced source-drain leakage current. This is attributed to the smaller density of radiation-induced positive oxide charge in the fluorinated field oxide compared to its control. This is consistent with experimental results showing that threshold voltage shifts of the field-oxide FETs are smaller than their control. In addition, the radiation-induced leakage currents of reverse biased n/sup +/p-junction diodes fabricated with the F implantation process are suppressed, suggesting that the generation of interface traps at the gate SiO/sub 2/-Si and the field SiO/sub 2/-Si interfaces is also reduced in the fluorinated devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Enhanced glucan formation of filamentous fungi by effective mixing, oxygen limitation and fed-batch processing (1992)

Glucan formation ofSchizophyllum commune andSclerotium glucanicum were investigated. Process data obtained during batch cultivation are presented. Glucan release can be improved by oxygen limitation. Thus, growth and glucan release are influenced by oxygen in opposite ways. Possible pathways of this oxygen-dependent regulation are discussed. A draft-tube/propeller system, rushtonturbine-, fan- and helicon-ribbon-impeller as well as a fundaspi and intermig agitator were tested. The 4-bladed fan impeller withd*=0.64 yielded the best results, since effective bulk mixing is much more important than bubble break up (micromixing) with regard to this system. Fed-batch cultivation always resulted in higher rates of glucan formation than the batch process.
Sensorless Control of Permanent Magnet Synchronous Motor Using Voltage Signal Injection (2013)

A successful application of vector control is subject to knowing the position of the rotor and, in synchronous machines, the knowledge of the initial position for a problem-free startup. The ability to read rotor position and perform the vector control algorithm without a position sensor is typically referred to as sensorless vector control. Traditional feedback from the rotor position sensor, or the sensor of mechanical angular velocity of the motor, is typically replaced with a computational block or an algorithm that uses the measured voltage and current to indicate the actual position of the motor. The article presents a sensorless control of the permanent magnet synchronous motor using an injection of high frequency voltage for rotor position estimation.DOI: http://dx.doi.org/10.5755/j01.eee.19.6.1583
Functional MRI of working memory and selective attention in vibrotactile frequency discrimination (2007)

These results support the notion that working memory and attention are organised in partly overlapping neural circuits. In contrast to previous reports in the visual or auditory domain, this study emphasises the involvement of the anterior insula in vibrotactile working memory and selective attention.
WEC Arrays with Power Packet Networks for Efficient Energy Storage and Grid Integration (2021)

This paper develops a power packet network (PPN) for integrating wave energy converter (WEC) arrays into microgrids. First a simple AC Resistor-Inductor-Capacitor (RLC) circuit operating at a power factor of one is introduced and shown to be a PPN. Next, an AC inverter-based network is analyzed and shown to be a PPN. Then this basic idea is utilized to asynchronously connect a WEC array to an idealized microgrid without additional energy storage. Specifically, NWECs can be physically positioned such that the incoming regular waves will produce an output emulating an N-phase AC system such that the PPN output power is constant. In the final example, the benefits of utilizing PPN phasing is demonstrated that analyzes a grid to substation to WEC array configuration. The numerical simulation results show that for ideal physical WEC buoy phasing of 60 and 120 degrees the energy storage system (ESS) peak power and energy capacity requirements are at the minimum.
Subclinical adenomas of the human pituitary. New light on old problems. (1983)

We studied 107 adenomas, found incidentally at autopsy in 100 pituitaries, by histologic and immunohistochemical techniques to elucidate their cellular composition and hormone content. No adenohypophyseal hormones were found in 54 (50%) of the adenomas, whereas prolactin was shown in 45 (42%). Of the remaining tumors, two contained prolactin and growth hormone, four contained adrenocorticotropic hormone, one contained thyroid-stimulating hormone, and one contained luteinizing hormone. These findings are consistent with the view that all adenohypophyseal cell types can give rise to neoplasms. No correlation was found between clinical history, autopsy findings, or cause of death and the presence or type of adenoma. The adenomas caused neither local symptoms nor endocrine abnormalities. The prevalence of various adenoma types differed between autopsy specimens and surgical material.
Atomistic Theory of Ostwald Ripening and Disintegration of Supported Metal Particles under Reaction Conditions (2012)

Understanding Ostwald ripening and disintegration of supported metal particles under operating conditions has been of central importance in the study of sintering and dispersion of heterogeneous catalysts for long-term industrial implementation. To achieve a quantitative description of these complicated processes, an atomistic and generic theory taking into account the reaction environment, particle size and morphology, and metal-support interaction is developed. It includes (1) energetics of supported metal particles, (2) formation of monomers (both the metal adatoms and metal-reactant complexes) on supports, and (3) corresponding sintering rate equations and total activation energies, in the presence of reactants at arbitrary temperature and pressure. The thermodynamic criteria for the reactant assisted Ostwald ripening and induced disintegration are formulated, and the influence of reactants on sintering kinetics and redispersion are mapped out. Most energetics and kinetics barriers in the theory can be obtained conveniently by first-principles theory calculations. This allows for the rapid exploration of sintering and disintegration of supported metal particles in huge phase space of structures and compositions under various reaction environments. General strategies of suppressing the sintering of the supported metal particles and facilitating the redispersions of the low surface area catalysts are proposed. The theory is applied to TiO(2)(110) supported Rh particles in the presence of carbon monoxide, and reproduces well the broad temperature, pressure, and particle size range over which the sintering and redispersion occurred in such experiments. The result also highlights the importance of the metal-carbonyl complexes as monomers for Ostwald ripening and disintegration of supported metal catalysts in the presence of CO.
Transcription factor AP-1 modulates the activity of the human foamy virus long terminal repeat (1991)

The human foamy virus (HFV) contains within the U3 region of its long terminal repeat (LTR) three perfect consensus sequences for the binding of the inducible transcription factor AP-1. Results of DNase I footprint protection and gel retardation assays demonstrated that proteins in extracts of HeLa and BHK-21 cells as well as bacterially expressed Jun and Fos proteins bind to these AP-1 sites. By conducting transient expression assays using chloramphenicol acetyltransferase plasmids carrying LTR sequences with point-mutated AP-1 sites, it was found that the three AP-1 sites contribute to the optimal activity of the HFV promoter. It is shown that induction of the HFV LTR by 12-O-tetradecanoylphorbol-13-acetate (TPA) and serum factors is mediated through the AP-1 sites.
Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization. (1990)

The T-cell antigen receptor (TcR) complex present on most T-cells is formed by a clone-specific disulfide-linked alpha/beta heterodimer noncovalently associated to the CD3 complex, the latter composed of five invariant polypeptides: gamma, delta, epsilon, zeta/zeta, or zeta/eta. The presence of conserved, oppositely charged, amino acids in the predicted transmembrane domains of all the subunits of the TcR.CD3 complex suggests that these residues may have a critical function in the assembly and/or stabilization of the complex. In order to analyze the role of the transmembrane-charged amino acids in the association and cell surface expression of the TcR.CD3 complex, we have carried out site-directed mutagenesis of Lys271 in the transmembrane domain of the TcR beta chain and analyzed the capacity of the altered chain to assemble in a TcR beta-negative T-cell line. Here we show that substitution of this positively charged residue by alanine or glutamine does not prevent cytoplasmic association of alpha and beta chains to form disulfide-linked heterodimers, but does abolish formation of an alpha/beta.CD3 complex and, consequently, its expression on the cell surface.
[Percutaneous transluminal angioplasty for stenotic dialysis arterio-venous fistulas]. (1992)

From December 1982 to January 1991, we performed fistulography on 40 patients who complained functional failure of arterio-venous dialysis fistula. And percutaneous transluminal angioplasty (PTA) was attempted on 15 patients (19 times) who revealed marked fistula stenosis. Initial successful rate was 78.9% and patency rate was 56.2% in the first 6 months. (75% in the first 6 months when angioplasty was initially successful). We describe the method of fistulography and PTA for stenotic dialysis fistulas, and evaluate the usefulness of PTA. And also we introduce our attempts for improving the initial successful rate and patency rate. In conclusion, when dialysis arterio-venous fistula is stenotic but not occlusive, PTA should be considered first before surgical treatment is done.
Determination of diorgano sulfide and tertiary phosphite antioxidants in polyolefins by slective oxidation with m-chloroperoxybenzoic acid (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of diorgano sulfide and tertiary phosphite antioxidants in polyolefins by slective oxidation with m-chloroperoxybenzoic acidGene E. KellumCite this: Anal. Chem. 1971, 43, 13, 1843–1847Publication Date (Print):November 1, 1971Publication History Published online1 May 2002Published inissue 1 November 1971https://pubs.acs.org/doi/10.1021/ac60307a050https://doi.org/10.1021/ac60307a050research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Natural Interaction White Paper (2007)

But what about the second one, calm technology? It is about interaction design, poetry, perception, quality, and it is almost completely unrealized. It is about much more subtle properties than quantities, miniaturization and wireless networking. Google returns less than 50 thousands results on the subject. The world forgot the most precious heritage of Weiser. This text is about calm technology [0] in the public space.
Bioconversion of methyl ricinoleate to 4‐hydroxy‐decanoic acid and to γ‐decalactone by yeasts of the genus Candida (1995)

The capacity of several strains of yeasts to do the bioconversion of methyl ricinoleate into gamma-decalactone, was studied in a medium containing this methylic ester of fatty acid as sole carbon source. Amongst the strains which are able to do this bioconversion, two types of behaviour are observed: some of the strains produce gamma-decalactone during all the incubation in bioconversion medium while others produce this aroma compound very quickly and then consume it fast too. The tested strains produce at the same time gamma-decalactone and the corresponding acid form (4-hydroxy-decanoic acid), and this, in variable proportions.
Association of Clinical Signs and Symptoms with Bacterial Findings in Acute Otitis Media (2004)

In acute otitis media (AOM), a means of prediction of the bacterial pathogen based on symptoms and signs would be valuable in selecting appropriate antimicrobial treatment. Children in the control arm (n=831) in the Finnish Otitis Media Vaccine Trial were prospectively observed in a study clinic setting from the age of 2 to 24 months. In patients with AOM, myringotomy with aspiration was performed, and middle ear fluid samples were cultured for bacterial pathogens. Symptoms and signs of respiratory infections were thoroughly recorded. Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae were the most common bacterial pathogens. Pneumococcal AOM was associated with more-severe AOM characterized by fever and earache. AOM due to H. influenzae was associated with eye symptoms and findings. Accurate prediction of a bacterial cause of infection based on symptoms and signs of AOM was not possible, but a specific cause was predicted in some situations, with a high probability of applicability to clinical practice.
Erasure-control coding for distributed networks (2005)

Channel coding has seen itself quickly emerge as a very promising technique in relatively new territory: distributed networks, where computing, communication and storage are extensively involved. In this environment, the distribution of rich media files to a large user population and the distribution of mission-critical data present special challenges for service providers and enterprises. Ensuring quality of service to these applications requires a combination of reliability, speed and scalability. Traditional packet-based networks endure poor end-to-end performance when packet-loss rates are high and a simple error-control strategy (through re-transmission) is applied. The paper will show how erasure-control coding, a special channel coding technique, plays an important part in promoting fault tolerance, and consequently quality of service across the network. Additionally, the construction of a class of maximum-distance-separable (MDS) array erasure codes is presented, which can be used in an adaptive way to efficiently control packet losses in a fluctuating network environment.
Lattice Boltzmann equation for relativistic quantum mechanics (2002)

Relativistic versions of the quantum lattice Boltzmann equation are discussed. It is shown that the inclusion of nonlinear interactions requires the standard collision operator to be replaced by a pair of dynamic fields coupling to the relativistic wave function in a way which can be described by a multicomponent complex lattice Boltzmann equation.
Acquisition and Analysis of Sonic Waveforms From a Borehole Monopole and Dipole Source for the Determination of Compressional and Shear Speeds and Their Relation to Rock Mechanical Properties and Surface Seismic Data (1990)

Abstract Classical sonic logging employs the acquisition and analysis of data with a simple monopole source. For this type of source, physics limits shear speed determination to speeds faster than the acoustic velocity of the borehole fluid. A dipole source excites the borehole flexural mode, providing a means to determine shear speed without this limitation. Propagation models and waveforms from computer simulations of hard and soft formations with both monopole and dipole sources are presented. These simulations are then compared to laboratory scale model data. Real-world borehole data acquired with both monopole and dipole sources, along with the instrumentation employed to acquire the data, are described. In particular, a combined monopole and dipole logging instrument with a high fidelity monopole and dipole receiver array is discussed. A processing algorithm for extracting compressional, shear and Stoneley speeds from monopole and dipole full waveform data is presented. Log examples are presented for hard, soft and extremely soft formations from both monopole and dipole sources. Application of log data to evaluation of rock mechanical properties, such as Poisson's ratio, fracture evaluation, and correlation to compressional and shear seismic data, is also discussed.
Mice immunized by primary vaginal Candida albicans infection develop acquired vaginal mucosal immunity (1995)

It has been postulated that systemic cell-mediated immunity (CMI) is an important host defense mechanism against Candida infections of the vagina. However, in an estrogen-dependent murine model of experimental vaginal candidiasis, we recently showed that systemic Candida-specific Th1-type CMI induced by immunization with Candida culture filtrate antigen had no effect on vaginal Candida population levels during the course of a vaginal infection. In the present study, mice given a second vaginal inoculation in the presence of peripheral Candida-specific Th1-type CMI induced by prior vaginal infection had anamnestic-type increased delayed-type hypersensitivity (DTH) responses, concomitant with significantly fewer Candida organisms in the vagina than in primary-infected mice. In addition, organisms in secondary-infected mice were fragmented and superficial penetration into the epithelium was reduced. The systemic presence of Candida-specific T suppressor (Ts) cells that significantly suppressed the infection-derived anamnestic DTH reactivity did not abrogate the protective effect in the vagina. Additional experiments showed that vaginally immunized mice were not protected from gastrointestinal or systemic candidiasis and, in contrast to mice with a second vaginal infection, did not demonstrate anamnestic DTH reactivity. These results suggest that a moderate level of local protection against a Candida vaginal infection can be achieved by vaginal immunization but that the protective role of acquired peripheral Candida-specific Th1-type reactivity at the vaginal mucosa appears to be limited.
Supporting Semantic Annotation of Educational Content by Automatic Extraction of Hierarchical Domain Relationships (2016)

The domain model is an essential part of an adaptive learning system. For each educational course, it involves educational content and semantics, which is also viewed as a form of conceptual metadata about educational content. Due to the size of a domain model, manual domain model creation is a challenging and demanding task for teachers or content (and metadata) authors. We propose a method for the automated acquisition of hierarchical relationships between relevant domain terms from educational content, which constitutes a fundamental step in the semantic composition of an educational course. The method is based on existing text mining methods and applied to educational content. We evaluate our approach by performing several experiments. The evaluation shows that the method's performance is very promising. A study in a real-user scenario reveals that despite the fact that utilization of our method does not necessarily improve the speed of the domain model creation nor does it reduce the overall difficulty of the task, a significant improvement in the quality of resulting domain models has been observed. Our work is a promising contribution to the growing field of automated domain model acquisition.
Enantiospecific Syntheses of 2,5-Dideoxy-2,5-imino-D-mannitol and -L-iditol from D-Mannitol (1991)

DMDP (2,5-dideoxy-2,5-imino-D-mannitol; 1) and 2,5-dideoxy-2,5-imino-L-iditol (2) have been synthesized in an enantiospecific way, starting from D-mannitol. Key transformations included the C-2 and C-5 configuration inversion of D-mannitol and the stereocontrolled cyclization of C 2 symmetrical 2,5-bis(hydroxymethyl)-3,4-dihydroxypyrrolidines 1 and 2.
Effect of Particle Size and Microstructure Properties on Encapsulated Orange Oil (1988)

The change of particle size distribution of encapsulated orange oil was achieved by varying the voltage supply of a centrifugal wheel atomizer during spray drying. Mean particle diameter of the encapsulated oil increased with the decrease in voltage supply. Moisture content, moisture sorption characteristics and bulk density were found to be independent of particle size distribution, whereas oil retention and surface oil content were significantly affected. The examination of surface morphology by scanning electron microscopy revealed that there was an observable increase in surface imperfections for large particles. Powders with large particles generally exhibited a more protective effect against oil oxidation than small particles.