gebhart/patrepeval huggingface dataset:
Correlated Fading Channel Simulator Based on the Overlap-Save Method (2013)

A fading channel emulator particularly suited for simulations of broadband communication systems is investigated. It is based on the overlap-save (OLS) method, traditionally used for efficient convolution. The resulting emulator shows a statistical accuracy comparable to the best known state-of-the-art techniques while greatly reducing complexity in terms of memory requirements. Therefore, it enables real-time simulation and makes the model particularly appealing for a hardware implementation. In addition, the introduction of an OLS-based interpolator enables simulation of very low Doppler frequencies with a high statistical precision.
Quantitative clinical nonpulsatile and localized visible light oximeter: design of the T-Stat tissue oximeter (2003)

We report the development of a general, quantitative, and localized visible light clinical tissue oximeter, sensitive to both hypoxemia and ischemia. Monitor design and operation were optimized over four instrument generations. A range of clinical probes were developed, including non-contact wands, invasive catheters, and penetrating needles with injection ports. Real-time data were collected (a) from probes, standards, and reference solutions to optimize each component, (b) from ex vivo hemoglobin solutions co-analyzed for StO<sub>2</sub>% and pO<sub>2</sub> during deoxygenation, and (c) from normoxic human subject skin and mucosal tissue surfaces. Results show that (a) differential spectroscopy allows extraction of features with minimization of the effects of scattering, (b) in vitro oximetry produces a hemoglobin saturation binding curve of expected sigmoid shape and values, and (c) that monitoring human tissues allows real-time tissue spectroscopic features to be monitored. Unlike with near-infrared (NIRS) or pulse oximetry (SpO<sub>2</sub>%) methods, we found non-pulsatile, diffusion-based tissue oximetry (StO<sub>2</sub>%) to work most reliably for non-contact reflectance monitoring and for invasive catheter- or needle-based monitoring, using blue to orange light (475-600 nm). Measured values were insensitive to motion artifact. Down time was non-existent. We conclude that the T-Stat oximeter design is suitable for the collection of spectroscopic data from human subjects, and that the oximeter may have application in the monitoring of regional hemoglobin oxygen saturation in the capillary tissue spaces of human subjects.
Haemophilia A and von Willebrand’s disease (2010)

Deficient or defective coagulation factor VIII (FVIII) and von Willebrand factor (VWF) can cause bleeding through congenital deficiency or acquired inhibitory antibodies. Recent studies on type 1 von Willebrand's disease (VWD), the most common form of the disease, have begun to explain its pathogenesis. Missense mutations of varying penetrance throughout VWF are the predominant mutation type. Other mutation types also contribute while about one-third of patients have no mutation identified. Enhanced clearance and intracellular retention contribute to pathogenic mechanisms. Chromogenic substrate (CS) methods to determine FVIII coagulant activity have several advantages over one-stage methods, which include minimal influence by variable levels of plasma components, notably lupus anticoagulant. Direct proportionality between FVIII activity and FXa generation results in high resolution at all FVIII levels, rendering the CS method suitable for measuring both high and low levels of FVIII activity. FVIII inhibitors in patients with inherited or acquired haemophilia A present several challenges in their detection and accurate quantification. The Nijmegen method, a modification of the Bethesda assay is recommended for inhibitor analysis by the International Society on Thrombosis and Haemostasis. Understanding potential confounding factors including heparin and residual FVIII in test plasma, plus optimal standardization can reduce assay coefficient of variation to 10-20%.These areas are all explored within this article.
Increased Intestinal Permeability Is Associated with the Development of Multiple Organ Dysfunction Syndrome in Critically Ill ICU Patients (1998)

We conducted a prospective, observational cohort study designed to compare intestinal permeability (IP) and development of multiple organ dysfunction syndrome (MODS) in a subset of critically ill patients in an intensive care unit (ICU). All patients with an expected ICU stay of 72 h or more were entered into the study, and IP was determined on a daily basis whenever possible from the urinary fractional excretion of orally administered lactulose and mannitol (LMR). Forty-seven consecutive patients were studied, and 28 developed MODS either at the time of admission or during their ICU course. These patients, as a group, had significantly worse IP at admission than did a non-MODS cohort (LnLMR: -2.10 +/- 1.10 versus -3.26 +/- 0.83). Those patients who developed MODS following admission also had a significantly greater admission IP than did the non-MODS group (-2.51 +/- 0.85). Differences in IP between cohorts could not be explained by differences in the incidence of systemic inflammatory response syndrome (SIRS)/sepsis or shock. With multivariate regression analysis, the only parameter present on admission that was predictive of subsequent MODS was IP. Differences in IP and the severity of organ dysfunction were also present (MODS severity mild: -3.01 +/- 0.72; moderate: -1.97 +/- 0.69; and severe: -1.12 +/- 0.96). Patients who developed MODS had a persistently abnormal IP during their ICU stay, and a significantly delayed improvement in their IP compared with the non-MODS cohort. We conclude that the development of MODS is associated with an abnormal and severe derangement of IP that is detectable prior to the onset of the syndrome. This observation lends credence to the premise that gastrointestinal (GI) dysfunction may be causally associated with the development of MODS in the critically ill patient.
A large chondroitin sulfate proteoglycan (PG-M) synthesized before chondrogenesis in the limb bud of chick embryo. (1986)

Extraction of stage 22-23 chick embryo limb buds that had been metabolically labeled with [35S]sulfate yielded heparan sulfate proteoglycan, small chondroitin sulfate proteoglycan, and large chondroitin sulfate proteoglycan (designated PG-M). PG-M constituted over 60% of the total macromolecular [35S]sulfates. It was larger in hydrodynamic size, richer in protein, and contained fewer chondroitin sulfate chains as compared to the predominant proteoglycan (PG-H, Mr congruent to 1.5 X 10(6)) of chick embryo cartilage. The chondroitin sulfate chains were notable for their large size (Mr greater than or equal to 60,000) and high content of nonsulfated chondroitin units (about 20% of the total hexosamine). Hexosamine-containing chains corresponding in size to N-linked and O-linked oligosaccharides were also present. The core protein was rich in serine, glutamic acid (glutamine), and glycine which together comprised about 38% of the total amino acids. Following chondroitinase AC II (or ABC) digestion, core molecules were obtained which migrated on sodium dodecyl sulfate gel electrophoresis as a doublet of bands with approximately Mr = 550,000 (major) and 500,000, respectively. The Mr = 550,000 core glycoprotein was structurally different from the core glycoprotein (Mr congruent to 400,000) of PG-H, as ascertained by tryptic peptide mapping and immunochemical criteria. Immunofluorescent localization of PG-M showed that the intensity of PG-M staining progressively became higher in the core mesenchyme region than in the peripheral loose mesenchyme, closely following the condensation of mesenchymal cells. Since the cell condensation process has been shown to begin with the increase of fibronectin and type I collagen concentration, the similar change in PG-M distribution suggests that PG-M plays an important role in the cell condensation process by means of its interaction with fibronectin and type I collagen.
Efficacy of 2-Amino-7-(1,3-Dihydroxy-2-Propoxymethyl)Purine for Treatment of Vaccinia Virus (Orthopoxvirus) Infections in Mice (2001)

We have previously shown that the N-7 substituted acyclic nucleoside analog 2-amino-7-[1,3-dihydroxy-2-propoxy)methyl]purine (compound S2242) is, both in vitro and in animal models, a potent inhibitor of the replication of several herpesviruses (Neyts et al., Antimicrob. Agents Chemother. 39:56-60, 1995). Here we report on the potent and selective antiviral activity of S2242 against vaccinia virus (VV), an orthopoxvirus. The 50% effective concentrations for inhibition of VV-induced cytopathic effect and viral DNA synthesis in cell culture were 2.4 and 0.2 microg/ml, respectively. We next studied the efficacy of S2242 in VV-infected mice. Immunocompetent NMRI mice that had been inoculated intravenously with VV developed tail lesions. Mice that had been treated for 5 consecutive days via the subcutaneous (s.c.) route with 100 mg of the diacetate ester prodrug of S2242 (compound H961) per kg of body weight did not develop any lesions and demonstrated no adverse effects. Severe combined immunodeficient (SCID) mice that had been inoculated intraperitoneally with VV became sick and died within 1 month after infection. Following treatment with H961 at 100 mg/kg for 10 consecutive days (either via oral gavage or s.c. injection) VV-inoculated SCID mice were completely protected, for at least 3 months, against virus-induced morbidity and mortality. At that time, no virus could be recovered from the organs of these mice (as assessed by titration for infectious virus, a DNA hybridization assay, and a PCR for VV-specific sequences). Compound S2242 and its oral prodrug H961 could be useful in treatment of orthopoxvirus infections.
Global attitude/position regulation for underwater vehicles (1999)

In this paper a nonlinear controller is designed for a 6 DOF model of an unmanned underwater vehicle (UUV) which includes both the kinematics and the dynamics. It is shown how the use of a Lyapunov function,consisting of aquadraticterm in the velocity (both linear and angular), a quadratic term in the position and a logarithmic term in the attitude leads to a design of a control law that achieves global asymptotic stabilization to an arbitrary set point in position/attitude. The control law is made linearly bounded by avoiding cancellation of some of the quadratic nonlinearities in the model. No information about the inertia matrix, thedamping,and the Coriolis/centripetal parameters is used in the controller, endowing it with a certain amount of parametric robustness. The control law is given in terms of the Modified Rodrigues parameters. An extensive simulation study shows that the proposed control law achieves excellent tracking for slowly changing trajectories, even though it is designed only for set point regulation. The nonlinear controller dramatically outperforms a liner controller.
Positron emission tomography in the clinical evaluation of metastatic cancer. (1996)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1996.14.3.691 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8622012 Positron emission tomography in the clinical evaluation of metastatic cancer. A J FischmanxA J FischmanSearch for articles by this author https://doi.org/10.1200/JCO.1996.14.3.691 First Page PDF © 1996 by American Society of Clinical Oncology
On a GARCH Model with Normal Scale Mixture Innovations (2012)

Recently, there has been a lot of interest in modeling real data with a heavy tailed distribution. A popular candidate is the so-called generalized autoregressive conditional heteroscedastic (GARCH) model. Unfortunately, the tails of normal GARCH models are not thick enough in some applications. In this paper, we propose a GARCH model with normal scale mixture innovations, the parameters estimation procedure using EM algorithm is also provided. It is shown that GARCH models with normal scale mixture innovations have tails thicker than those of normal GARCH models. Therefore, the GARCH models with normal scale mixture innovations are more capable of capturing the heavy-tailed features in real data. Shanghai Stock Market Index as a real example illustrates the results.
A comparison of pruning methods for relational concept learning (1994)

Pre-Pruning and Post-Pruning are two standard methods of dealing with noise in concept learning. Pre-Pruning methods are very efficient, while Post-Pruning methods typically are more accurate, but much slower, because they have to generate an overly specific concept description first. We have experimented with a variety of pruning methods, including two new methods that try to combine and integrate pre- and postpruning in order to achieve both accuracy and efficiency. This is verified with test series in a chess position classification task. 1 Introduction Inductive Logic Programming (ILP) or Relational Learning has established itself as one of the major research areas in the field of Machine Learning [Muggleton, 1992, Lavrac and Dzeroski, 1993]. The ability to define concepts from data distributed in separate relational tables makes ILP methods particularly appropriate for learning from relational databases (see e.g. [Dzeroski and Lavrac, 1993]). However, data from real-world problem...
Type I Interferon Sensitizes Lymphocytes to Apoptosis and Reduces Resistance to <i>Listeria</i> Infection (2004)

Infection with Listeria monocytogenes causes lymphocyte apoptosis that is mediated by the actions of the pore-forming virulence factor listeriolysin O (LLO). Previous work showed that activated lymphocytes were highly sensitive to LLO-induced apoptosis, whereas resting lymphocytes were less susceptible. We now show that mice deficient in the type I interferon (IFN) receptor were more resistant to Listeria infection and had less apoptotic lesions than wild-type counterparts. Furthermore, treatment of resting splenic lymphocytes with recombinant IFN-alphaA enhanced their susceptibility to LLO-induced apoptosis. Together, these data suggest that type I IFN signaling is detrimental to handling of a bacterial pathogen and may enhance the susceptibility of lymphocytes undergoing apoptosis in response to bacterial pore-forming toxins.
Increased Recruitment of Hematopoietic Progenitor Cells Underlies the Ex Vivo Expansion Potential of FLT3 Ligand (1997)

The ligand for flt-3 (FLT3L) exhibits striking structural homology with stem cell factor (SCF) and monocyte colony-stimulating factor (M-CSF) and also acts in synergy with a range of other hematopoietic growth factors (HGF). In this study, we show that FLT3L responsive hematopoietic progenitor cells (HPC) are CD34+CD38-, rhodamine 123dull, and hydroperoxycyclophosphamide (4-HC) resistant. To investigate the basis for the capacity of FLT3L to augment the de novo generation of myeloid progenitors from CD34+CD38- cells, single bone marrow CD34+CD38- cells were sorted into Terasaki wells containing serum-free medium supplemented with interleukin-3 (IL-3), IL-6, granulocyte colony-stimulating factor (G-CSF), SCF (4 HGF) +/- FLT3L. Under these conditions, FLT3L recruited approximately twofold more CD34+CD38- cells into division than 4 HGF alone. The enhanced proliferative response to FLT3L was evident by day 3 and was maintained at all subsequent time points examined. In accord with these findings, we also show that transduction of CD34+CD38- cells with the LAPSN retrovirus is enhanced by FLT3L. The results of these experiments therefore indicate that increased recruitment of primitive HPC into cell cycle underlies the ex vivo expansion potential of FLT3L and also its ability to improve retroviral transduction of HPC.
Predicting Reservoir Characteristics From Drilling and Hydrocarbon-Gas Data Using Advanced Computational Mathematics (2009)

Abstract Formation characteristics are predicted using an advanced computational mathematical method and using hydrocarbon-gas and drilling data as input. Robust predictions of porosity and saturation are made in vertical and horizontal wells, in clastic and carbonate reservoirs. The potential of the technology to augment and complement wireline and LWD technology is identified and applications where these conventional data are unavailable are considered.
Involvement of the NLRP3 Inflammasome in Innate and Humoral Adaptive Immune Responses to Fungal β-Glucan (2009)

Fungal beta-glucan, such as curdlan, triggers antifungal innate immune responses as well as shaping adaptive immune responses. In this study, we identified a key pathway that couples curdlan to immune responses. Curdlan promoted the production of the proinflammatory cytokine IL-1beta by dendritic cells and macrophages through the NLRP3 inflammasome. Stimulation with Candida albicans and Saccharomyces cerevisiae also triggered the NLRP3 inflammasome-mediated IL-1beta production. In vivo, NLRP3 was required for efficient Ag-specific Ab production when curdlan was used as an adjuvant, whereas it was dispensable for the induction of Th1 and Th17 cell differentiation. Furthermore, stimulation of purified B cells with curdlan-induced CD69 up-regulation and IgM production while stimulation with other NLRP3 inflammasome activators, such as silica and aluminum salt, did not. Notably, this induction required NLRP3 but was independent of Toll-like receptor and IL-1 receptor family signaling, suggesting the presence of NLRP3-dependent and IL-1 receptor family independent mechanisms in B cells responsible for Ab responses. Collectively, these findings reveal a critical role for the NLRP3 inflammasome in the regulation of antifungal innate immune responses as well as B cell activation.
A review of satellite and airborne sensors for remote sensing based detection of minefields and landmines (2004)

This paper focuses on the use of space and airborne sensors that can be applied to detect landmines and minefields. First the landmine and minefield problem is addressed and examples of the use of remote sensing images are presented that could provide valuable information for the mine action process and assist in conventional minefield and landmine detection methods. This is followed by an overview on relevant (declassified) aspects related to strategic overhead detection techniques developed by the military/intelligence community as well as those of civilian space and airborne remote sensing programmes. The airborne sensing techniques describe the state of the art of sensors such as optical (film, multi- and hyperspectral sensors), thermal infrared as well as microwave sensors and their suitability--limitations for remote sensing based minefield and landmine detection purposes.
High Speed Bipolar ICs Using Super Self-aligned Process Technology (1980)

We have developed a new bipolar process technology, called SST. The emitter region, base p region, base p+ region, base p+ polysilicon electrode and emitter contact window of NPN transistor are formed by one mask photolithography process. The transistor active regions are all self-aligned. Therefore, small-size transistors can be realized and high performance is achieved by the decreased collector-base junction capacitance. A new bipolar integrated circuit using SST gave a 63 ps/gate propagation delay time and 0.043 pJ/gate speed-power product.
Drunk User Interfaces (2018)

Breathalyzers, the standard quantitative method for assessing inebriation, are primarily owned by law enforcement and used only after a potentially inebriated individual is caught driving. However, not everyone has access to such specialized hardware. We present drunk user interfaces: smartphone user interfaces that measure how alcohol affects a person's motor coordination and cognition using performance metrics and sensor data. We examine five drunk user interfaces and combine them to form the "DUI app". DUI uses machine learning models trained on human performance metrics and sensor data to estimate a person's blood alcohol level (BAL). We evaluated DUI on 14 individuals in a week-long longitudinal study wherein each participant used DUI at various BALs. We found that with a global model that accounts for user-specific learning, DUI can estimate a person's BAL with an absolute mean error of 0.005% ± 0.007% and a Pearson's correlation coefficient of 0.96 with breathalyzer measurements.
Analysis of the CD4 coreceptor and activation-induced costimulatory molecules in antigen-mediated mature T lymphocyte death (1995)

We have compared the signaling requirements for activation and lymphokine production in mature T lymphocytes to those required for TCR-driven programmed cell death (PCD). Both processes require TCR engagement and ligation of the CD4 coreceptor in the case of a T cell clone that recognizes Ag in the context of an MHC class II molecule. By contrast, stimulation through the CD28/B7 pathway does not appear to positively or negatively influence TCR-induced PCD, although it was required for IL-2 production in both resting and proliferating T cells. T cells that had been activated and induced to proliferate with IL-2 were found to express high levels of IL-2 mRNA upon TCR rechallenge, without a requirement for accessory cells. This was due to a strong up-regulation of the B7-1 molecule, but not the B7-2 molecule, on the T cell surface. These T cells that strongly costimulate each other are highly susceptible to TCR-induced death providing independent evidence that costimulatory signals are not protective. Thus, these results provide evidence that in mature T cells there exists a difference in the requirement for CD28 to achieve activation and IL-2 production compared with TCR-mediated PCD.
A NEW ROTATING-PROBE EDDY CURRENT METHOD FOR INSPECTING BAR SURFACE (1975)

This paper describes new eddy current test equipment developed by Bethlehem Steel for inspecting asrolled bars for surface defects. The equipment has been installed and used in production to inspect 1 3/4 to 4 in. (44 to 101 mm) round bars. The equipment rotates an eddy current probe around an advancing bar with the probe held a preset minimum distance from the bar surface. Key features of the bar-testing equipment are that it: 1) maintains a constant test sensitivity for varying probe-to-bar spacing, 2) indicates as defective only those defects which exceed a preselected length and depth, and 3) automatically paint-marks detected defects. /Author/
Causal event graphs cyber-physical system intrusion detection system (2013)

This paper proposes to model the causal relationship between devices in a cyber-physical system using a Bayesian Networks and a new Bayesian Network expansion called causal event graphs. Unique paths through causal event graphs are used to model deterministic signatures which can be used by an intrusion detection system to classify events. A case study is provided to demonstrate the effectiveness of the method for classifying cyber and physical events in an electric transmission system. Bulk electric transmission systems are dynamic cyber-physical systems. Cyber monitoring and control systems are used to remotely operate the power system and to detect and react to physical disturbances. The communication layer associated with this monitoring and control functionality also enables cyber attacks against transmission systems. Existing regulations require utilities to use monitoring techniques such as intrusion detection systems to monitor cyber activity at electronic security perimeter boundaries. Recent attacks demonstrate that monitoring restricted to boundaries is insufficient to detect all attack threats. The methodology described in this paper provides a means to develop a model based defense in depth solution for electric transmission system intrusion detection.