gebhart/patrepeval huggingface dataset:
Geometric Path Planning for General Robot Manipulators (2009)

In this paper, we present a distance transform-based geometric path planning algorithm suitable for robots with vision capability. We show that the proposed approach can reduce the computation time needed to find an optimal collision-free path compared to other path planning algorithms by utilizing the output of the computer vision module and by eliminating any extra work to model the workspace of the robot. We illustrate the application of this algorithm in 2D and 3D and present two optimization algorithms to reduce the number of waypoints and shorten the Euclidean distance of the path. Finally, we show how this algorithm can be incorporated in systems with on-board sensors and how the output of the vision module can be streamed to the algorithm to allow real-time path planning. Geometric path planning is a robust alternative algorithm for computing a collision free path connecting the initial and final configurations of a robot with a minimal number of waypoints in 2D and 3D environments. It provides a geometric description of the robot motion given a mapping and a description of the obstacles in the workspace. The algorithm outputs the (x,y,z) coordinates of the path in the workspace which is then passed to a custom inverse kinematics block to compute the revolute and prismatic joint variables in the configuration space. In this paper, we illustrate the application of this algorithm by computing an optimal path for the end-effector; however, this algorithm can be applied to all the origins of the Denavit Hartenburg frames or a set of floating control points in the links to ensure that the entire kinematic chain follows a collision free path. The motivation for this path planning approach is to minimize the computation time needed to find a collision free path for sensor-equipped robots by eliminating the representational cost incurred by modeling the workspace. This is done by designing the path planning algorithm around the output of the vision module, mainly the segmented image of the workspace.
Video lensfree microscopy of 2D and 3D culture of cells (2014)

Innovative imaging methods are continuously developed to investigate the function of biological systems at the microscopic scale. As an alternative to advanced cell microscopy techniques, we are developing lensfree video microscopy that opens new ranges of capabilities, in particular at the mesoscopic level. Lensfree video microscopy allows the observation of a cell culture in an incubator over a very large field of view (24 mm<sup>2</sup>) for extended periods of time. As a result, a large set of comprehensive data can be gathered with strong statistics, both in space and time. Video lensfree microscopy can capture images of cells cultured in various physical environments. We emphasize on two different case studies: the quantitative analysis of the spontaneous network formation of HUVEC endothelial cells, and by coupling lensfree microscopy with 3D cell culture in the study of epithelial tissue morphogenesis. In summary, we demonstrate that lensfree video microscopy is a powerful tool to conduct cell assays in 2D and 3D culture experiments. The applications are in the realms of fundamental biology, tissue regeneration, drug development and toxicology studies.
Tebentafusp: T Cell Redirection for the Treatment of Metastatic Uveal Melanoma (2019)

Metastatic disease from uveal melanoma occurs in almost 50% of patients suffering from this ocular tumour, with median survival from development of symptoms being around 1 year. In contrast to cutaneous melanoma, kinase inhibitors and immune checkpoint inhibitors are usually ineffective in patients with metastatic uveal melanoma. Tebentafusp is a novel form of immunotherapy based on the immune-mobilising monoclonal T cell receptor against cancer (ImmTAC) platform, which comprises a soluble T cell receptor that is fused to an anti-CD3 single-chain variable fragment. The T cell receptor domain of tebentafusp targets cells present a human leukocyte antigen-A*02:01 complexed with a peptide derived from the melanoma-associated antigen gp100, which is expressed strongly by melanoma cells, weakly by normal melanocytes and minimally by other tissues. The anti-CD3 domain recruits CD3+ T cells (and, indirectly, other immune cells), redirecting these to the melanoma cells. The most common adverse events with tebentafusp are manageable and usually transient. Early survival data in patients with metastatic uveal melanoma are promising when considered alongside historical data. Based on these encouraging results, a randomised study comparing tebentafusp to investigator's choice of therapy in metastatic uveal melanoma is ongoing.
Temporal structure of in vivo growth hormone secretory events in humans (1991)

The time course of spontaneous growth hormone (GH) secretion was studied in 12 normal men by analyzing serum GH concentrations measured in blood collected at 5-min intervals over 24 h with a multiple-parameter deconvolution model to simultaneously resolve endogenous GH secretory and clearance rates. Twenty-four-hour profiles of serum GH concentrations were accounted for by an average of 12 +/- 1.2 (SE) discrete GH secretory bursts having a mean half-duration (duration at half-maximal amplitude) of 25 +/- 2.3 min, indicating that 95% of daily GH secretion occurred in 8.8 h. The majority (96%) of GH was secreted in volleys composed of multiple (4.0 +/- 0.4) discrete secretory bursts. Such volleys of GH secretion were separated by 171 +/- 19 min, whereas their constituent individual secretory events occurred every 36 +/- 1.7 min (P = 0.0001). Between secretory volleys, calculated GH secretory rates fell asymptotically to zero. Significant positive and negative autocorrelations were observed for the series consisting of successive GH secretory burst mass and interburst intervals, respectively. Linear regression analysis revealed significant negative correlations between the mass of GH secreted per burst and both the preceding and following interburst intervals. Estimates of the half-life of endogenous GH (17 +/- 1.7 min) and of the endogenous GH production rate (0.25 +/- 0.033 mg/m2 for an assumed distribution volume of 7.9% body wt) agreed well with earlier independent measurements. We conclude that the human pituitary gland secretes GH in volleys consisting of multiple secretory bursts, without measurable intervening tonic secretion. This pattern of in vivo GH release in normal humans is consistent with a model of high-frequency GH-releasing hormone secretory events superimposed on low-frequency episodes of somatostatin withdrawal.
Improved micro-optoelectromechanical systems deformable mirror for<i>in vivo</i>optical microscopy (2012)

Micro-optoelectromechanical systems (MOEMS) deformable mirrors are being developed for focus control in miniature optical systems including endoscopic microscopes and small form-factor camera lenses. A new process is described to create membrane mirrors made from the photoset polymer SU-8. The SU-8 also serves as the adhesive layer for wafer bonding, resulting in a simple, low cost fabrication process. The process details and the optical properties of the resulting focus control mirrors, which have a diameter of 2 mm, a stroke in excess of 8 μm and very low residual aberration, are described. Multiple actuation electrodes allow active control of more than 1.4 μm peak-to-peak of wavefront spherical aberration. The MOEMS mirror is demonstrated in a confocal microscope in which it provides focus control during capture of in vivo images.
Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14 (2002)

Unexpectedly, neither mutation analysis of cDNAs nor levels of mRNAs indicated which of the candidate genes might be affected by the wr mutation. The possibility arises that there might be hitherto unknown effects of mutations, in addition to structural changes of the mRNA or regulatory abnormalities.
640 Gb/s transmission of sixty-four 10 Gb/s WDM channels over 7200 km with 0.33 (bits/s)/Hz spectral efficiency (2003)

Sixty-four 10 gb/s WDM channels were transmitted over 7200 km is a spectral bandwidth of 15.1 nm for a spectral efficiency of 0.33 (bits/s)Hz. Error free operation was achieved for all channels.
A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA. (1993)

Apoptosis (programmed cell death) can be difficult to detect in routine histological sections. Since extensive DNA fragmentation is an important characteristic of this process, visualization of DNA breaks could greatly facilitate the identification of apoptotic cells. We describe a new staining method for formalin-fixed, paraffin-embedded tissue sections that involves an in situ end-labeling (ISEL) procedure. After protease treatment to permeate the tissue sections, biotinylated nucleotides are in situ incorporated into DNA breaks by polymerase and subsequently stained with DAB via peroxidase-conjugated avidin. Staining of cells with the morphological characteristics of apoptosis was demonstrated in tissues known to exhibit programmed cell death, i.e., prostate and uterus after castration, tumors, lymph node follicles, and embryos. Apoptotic cells could be discriminated morphologically from areas of labeled necrotic cells, in which DNA degradation also occurs. Because apoptosis is relatively easily recognized in H&E-stained sections of involuting prostates of castrated rats, we used this model system to validate the ISEL method for the quantification of apoptotic cells. A high correlation was found between the fractions of ISEL-labeled cells and the fractions of apoptotic cells that were morphologically determined in adjacent sections. We conclude that ISEL is a useful technique for quantification of apoptosis in paraffin sections, especially for those tissues in which morphological determination is difficult. Furthermore, this new staining method enables the use of automated image cytometry for evaluating apoptosis.
THE FIRST CASE OF DIRECT COUPLING OF HETEROCYCLES WITH CA LI XA REN ES. REACTION OF RESORCINARENES WITH 1,2,4-TRIAZIN-5(2H)-ONES (2004)

Article THE FIRST CASE OF DIRECT COUPLING OF HETEROCYCLES WITH CA LI XA REN ES. REACTION OF RESORCINARENES WITH 1,2,4-TRIAZIN-5(2H)-ONES was published on February 1, 2004 in the journal Heterocyclic Communications (volume 10, issue 1).
GENETICS OF ALCOHOLISM (1989)

Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A ...Read More
The inverse-narrow-width effect (1986)

For the first time an analytical expression can simulate the inverse-narrow-width effect. The inverse-narrow-width effect is a reduction in the threshold voltage of a MOSFET with decreasing channel width. We compare the model with experimental threshold voltage data from small-geometry PMOS devices with fully recessed isolation oxides and an inverse-narrow-width effect is predicted.
Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motif. (1990)

The human immunodeficiency virus type 1 (HIV-1) transactivator Rev is a nuclear protein that regulates expression of certain HIV-1 transcripts by binding to an RNA target element (the RRE) present in these transcripts. A short arginine-rich sequence in Rev contains the signals required to direct this protein into nuclei, where it associates preferentially with nucleoli. We created a steroid-inducible transactivator by fusing Rev with the steroid-binding domain of the glucocorticoid receptor (GR). This Rev/GR protein remains inactive in the cytoplasm when steroids are absent, but it enters the nucleus and initiates transactivation within minutes after exposure to dexamethasone. Although the GR moiety is sufficient to transport Rev/GR into nuclei, mutation of certain residues in the arginine-rich region blocks nucleolar localization and also inhibits transactivation. We find that other mutations in this region, however, can abolish the function of Rev/GR without affecting its localization; the latter phenotype may reflect a specific defect in binding of the RRE.
Analysis of Measurement Errors in Rail Vehicles’ Pantograph Inspection System (2016)

The paper presents an approach to evaluation of height measurement errors in laser scanning inspection system. The system, consisting of a laser line generator and a specialized camera, is dedicated to diagnosing carbon contact strips of railway vehicles’ pantographs. While height measurement resolution is easily computable based on system parameters, determining the measurement error is troublesome due to numerous impacts. As width-to-height ratio of the scanned object is very high, typical patterns applied in references for error determination cannot be used. A set of real-case contact strips have been selected and used as patterns for determining scanning system errors. Both peak and RMS errors have been quantified to evaluate accuracy of wear estimation and defect identification, respectively.DOI: http://dx.doi.org/10.5755/j01.eie.22.3.15309
NATURAL AND CONTROLLED POLLINATION IN SESAME (1944)

Journal Article NATURAL AND CONTROLLED POLLINATION IN SESAME Get access D. G. LAKGHAM D. G. LAKGHAM Instituto Experimental de Agricultura y ZootecniaCaracas, Venezuela Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 35, Issue 8, August 1944, Pages 255–256, https://doi.org/10.1093/oxfordjournals.jhered.a105398 Published: 01 August 1944
Tubing-Conveyed Perforating With Hydraulic Set Packers and a New High-Pressure Retrievable Hydraulic Packer (1984)

Abstract The oil industry has recently begun using tubing conveyed perforating (TCP) guns with much greater frequency than in the past. The advantages of larger explosives, higher shot density, unlimited gun length, and removal or reduction of formation damage by perforating with a pressure differential into the wellbore have caused the number of wells perforated with TCP guns to increase at a time when the number of wells perforated industry-wide has drastically decreased. Although these advantages are becoming well known, a superior well completion design and procedure making use of hydraulic set packers in conjunction with TCP guns has not yet been "discovered" by the oil and gas industry except for a few isolated applications. This paper outlines the various capabilities and options made possible in completions using hydraulic packers and TCP guns, including wellhead installation before perforating, circulation capability until just before perforating, and "floating" seal designs. Various completion designs for differing situations of pressure, temperature, and corrosion are presented. A limiting factor in the use of TCP guns in high pressure completions has been the high cost of gun failure caused by the lack of availability of a retrievable hydraulic packer capable of differential pressures above about 6,000 psi (41.4 MPa). The recent development of such a packer, with demonstrated differential pressure rating of 12,000 psi (82.7 MPa) and temperature rating of 450°F (232°C), makes many high pressure, high cost completions likely candidates for the TCP gun-hydraulic packer completion design. This paper includes a case history of such a completion. The discussion describes the types of hydraulic packers used with TCP guns and the seal systems associated with each, the types of firing systems used, and gives two typical completion procedures; one the case history just referred to, and one, a case history of a low pressure completion.
AN EDGE DEVICE FOR SUPPORTING INTERNET INTEGRATED SERVICES OVER SWITCHED ATM NETWORKS (1998)

This paper presents an architecture for combining the Internet approach for the support of multimedia services with switched ATM network technology. As the idea is to avoid changes on the underlying technologies, we introduce an Edge Devise (ED) which provides all functionality required for the efficient support of Internet Integrated Services (IntServ) through switched ATM networks. Core functions of the ED are the interoperability between RSVP (Resource Reservation Protocol) and broadband signaling at the control plane, the synergy between RSVP and DiffServ (Differentiated Services) at the User plane, the support of multicast services and address resolution via VC management, as well as charging and billing. Compared to proposed Internet routers the ED presents increased functionality both at the user and Control plane as it fully exploits the advantages of IP to ATM and vice versa. The paper proposes a set of RSVP / signaling scenarios for efficiently using the control capabilitie...
Development of a line-focus refractive concentrator array for space applications (2002)

The NASA Lewis program in refractive photovoltaic concentrator technology has made tremendous strides over the past few years. Studies have shown that, compared to other concentrator systems, the line-focus refractive concentrator concept offers a number of very important advantages: relaxation of precise array tracking requirements to only a single axis; low-cost mass production of the lens material; improved shape error tolerance, etc. The first active space flight experiment of the domed refractive concentrator technology was conducted on the PASP Plus Flight Experiment. Early results from this experiment have confirmed the high performance and viability of this concentrator approach. Significant progress has also been made in the development of the panel structure. New panel designs emphasize light weight, high stiffness, stowability and ease of manufacturing and assembly. Based on these recent advancements, the program has now shifted its emphasis to an array-level space flight demonstration.
Ion implant monitoring with thermal wave technology (1985)

A new method, based on thermal wave technology, is used to monitor the ion implantation process in silicon. It is a noncontact, nondestructive technique that requires no special sample preparation or processing, has high sensitivity even at low dose, and provides a one-micron spatial resolution capability. This method allows, for the first time, the ability to monitor the critical ion implantation process directly on the patterned product integrated circuit wafers as well as on the usual test wafers.
Inhibition of Bone Resorption by Acetazolamide in the Rat<sup>1</sup> (1970)

The carbonic anhydrase inhibitor, acetazolamide, has been found to elicit a hypocalcemic response in acutely nephrectomized rats. This effect cannot be attributed to changes in pCO2, pH citrate, phosphate or protein. Administration of acetazolamide to parathyroidectomized- nephrectomized rats has been shown to inhibit the hypercalcemic response to parathyroid extract and dibutyryl cyclic 3',5'- AMP. The hypercalcemic response to epinephrine was not inhibited in the same preparation. These data are consistent with the hypothesis that cyclic 3',5'-AMP is the second messenger of parathyroid hormone in its action on bone, and that carbonic acid production may be a later, or possibly the final, messenger of the hormone.(Endocrinology87: 1129, 1970)
ICP22 homolog of equine herpesvirus 1: expression from early and late promoters (1992)

The complete nucleotide sequence of the short region, made up of a unique segment (Us; 6.5 kb) bracketed by a pair of inverted repeat sequences (IR; 12.8 kb each), of the equine herpesvirus 1 (EHV-1) genome has been determined recently in our laboratory. Analysis of the IR segment revealed a major open reading frame (ORF) designated IR4. The IR4 ORF exhibits significant homology to the immediate-early gene US1 (ICP22) of herpes simplex virus type 1 and to the ICP22 homologs of varicella-zoster virus (ORF63), pseudorabies virus (RSp40), and equine herpesvirus 4 (ORF4). The IR4 ORF is located entirely within each of the inverted repeat sequences (nucleotides [nt] 7918 to 9327) and has the potential to encode a polypeptide of 469 amino acids (49,890 Da). Within the IR4 ORF are two reiterated sequences: a 7-nt sequence tandemly repeated 17 times and a 25-nt sequence tandemly repeated 13 times. Nucleotide sequence analyses of IR4 also revealed several potential cis-regulatory sequences, two TATA sequences separated by 287 nt, an in-frame translation initiation codon following each TATA sequence, and a single polyadenylation site. To address the nature of the mRNA species encoded by IR4, we used Northern (RNA) blot and S1 nuclease analyses. RNA mapping data revealed that IR4 has two promoters that are regulated differentially during a lytic infection. A 1.4-kb mRNA appears initially at 2 h postinfection and is an early transcript since its synthesis is not affected by the presence of phosphonoacetic acid, an inhibitor of EHV-1 DNA replication. In contrast, a 1.7-kb mRNA appears at later times postinfection and is designated as a gamma-1 transcript, since its synthesis is significantly reduced by phosphonoacetic acid. These IR4-specific mRNAs are 3' coterminal, have unique 5' termini, and would code for in-frame, overlapping, carboxy-coterminal proteins of 293 and 469 amino acids, respectively. Interestingly, the site of homologous recombination to generate the genome of EHV-1 defective interfering particles that initiate persistent infection occurs between nt 3244 and 3251 of UL3 (ICP27 homolog) and nt 9027 and 9034 of IR4 (ICP22 homolog). Thus, this recombination event would generate a unique ORF that would encode a potential protein whose amino end was derived from the N-terminal 193 amino acids of the ICP22 homolog and whose carboxyl end was derived from the C-terminal 68 amino acids of the ICP27 homolog.
Layout driven re-synthesis for low power consumption LSIs (1997)

A new technology re-mapping method named LDR (LayoutDriven Re-synthesis), which is applied after placement, is proposed.LDR executes re-mapping and re-placement simultaneouslyin order to minimize power consumption with placementinformation.High switching activity nets are concealed insidethe re-mapped cells or are shortened by re-placement in LDR.To estimate power consumption, LDR uses static power estimatorfor combinational circuits.LDR also calculates wirecapacitances accurately based on placement information toevaluate power.Experimental results show that 20% powerreduction compared with original circuits is performed by proposed method.
Behavior learning and group evolution for autonomous multi-agent robot (2002)

In this research, the evolutionary algorithm is applied to behavior learning of an individual agent in multi-agent robots. Each robot which is an agent is given two behavior duties both collision avoidance from the other agent and target (food point) reaching for recovering self-energy. In the problem for two conflicting behaviors, collision avoidance and target reaching motion, of multi-agent robots the learning method of behavior based on the self-energy and the behavior gain of each agent was discussed in the author's previous paper (1996). In this paper, he performs the simulation with the additional algorithm of the group evolution which the parameters of the most excellent agent are copied to a dead agent, that is, an agent lost its energy. It was confirmed in the simulation that each agent has abilities of both behavior learning and group evolution.
Phase Relations, Quasicontinuous Spectra and Subfemtosecond Pulses in High-Order Stimulated Raman Scattering with Short-Pulse Excitation (2000)

High-order stimulated Raman scattering for pumping by ps and sub-ps pulses is studied in the frame of a time-domain approach without the slowly varying envelope approximation. Formation of pulse trains with sub-fs durations in the ps-pump regime is demonstrated using external phase compensation. For sub-ps excitation a novel broadening mechanism of Raman lines is predicted that leads to a quasicontinuous spectrum and permits one to generate single sub-fs pulses. We predict also essential shortening of a delayed fs-probe pulse by the Raman oscillations without phase control.