gebhart/patrepeval huggingface dataset:
Patterns of Resistance and Incomplete Response to Docetaxel by Gene Expression Profiling in Breast Cancer Patients (2005)

A specific and consistent gene expression pattern was found in residual tumors after docetaxel treatment. These profiles provide therapeutic targets that could lead to improved treatment.
Occlusion Aware Motion Compensation for Video Frame Rate Up-Conversion (2010)

Since the emergence of high definition (HD) display technologies, video standards conversion problem has become an important issue in storage, transmission and display of video content. Video frame rate up-conversion (FRUC) is considered as a standard task for today’s HD displays because these displays reach high refresh rates of at least 100/120 Hz and low video frame rates should be pulled up by a factor of 2 or more before display. Motion compensated FRUC techniques are proposed to avoid motion blur and motion judder at high refresh rates, but these techniques suffer from spatial inconsistencies and artifacts especially in occluded regions of the interpolated frames. This paper introduces a new video FRUC method that aims to remove both motion judder and occlusion artifacts and generate smooth object motion for high quality displays. An occlusion adaptive overlapped block motion compensation (OBMC) technique is proposed, which provides spatio-temporally consistent frame interpolation. Covered/uncovered regions are detected by analyzing the discontinuities of the motion vector field. The occlusion regions are interpolated using this covered/uncovered decision and a new error metric that measures spatial consistency. Compared to existing methods, the proposed algorithm achieves FRUC with fewer artifacts and better spatial resolution especially in occluded areas.
Lignans From Taxus wallichiana (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLignans From Taxus wallichianaRoger W. Miller, Jerry L. McLaughlin, Richard G. Powell, Ronald D. Plattner, David Weisleder, and Cecil R. Smith Jr.Cite this: J. Nat. Prod. 1982, 45, 1, 78–82Publication Date (Print):January 1, 1982Publication History Published online1 July 2004Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/np50019a007https://doi.org/10.1021/np50019a007research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
UNDP - World Bank water and sanitation program : annual report 1989-90 (1990)

This report covers activities of the UNDP-World Bank Water and Sanitation Program during calendar year 1989 through June 1990. It begins with a summary of Program activities, and a forecast of the challenges that lie ahead. The overriding focus of the Program is the delivery of sustainable services to the poor. Sustaining services to this often-neglected group is a difficult task, one that requires a long-term commitment and a broad framework for sector development. Within this framework, financial, institutional, and other nontechnological issues play an important role. Some dominant nontechnological issues in the sector are identified and Program activities confronting them are outlined. The report includes a review of Program finances and a description of bilateral contributions to the Program and concludes with accounts of Program activities in individual countries during 1989-90.
Calcium at the Crossroads of Signaling (2002)

### Calcium Signals: A Central Paradigm in Stimulus–Response Coupling

Cells must respond to an array of environmental and developmental cues. The signaling networks that have evolved to generate appropriate cellular responses are varied and are normally composed of elements that include a
Heat Storage and Transport (1985)

System for storing large amounts of heat per unit volume comprises encapsulated sealed pellets of phase-change materials dispersed and suspended in inert fluid-transport medium.
Chest Physical Therapy for Patients in the Intensive Care Unit (1996)

Chest physical therapy is used in the intensive care unit (ICU) to minimize pulmonary secretion retention, to maximize oxygenation, and to reexpand atelectatic lung segments. This article reviews how chest physical therapy is used with patients who are critically ill. A brief historical review of the literature is presented. Chest physical therapy treatments applicable to patients in the ICU are discussed. Postural drainage, percussion, vibration, breathing exercises, cough stimulation techniques, and airway suctioning are described in detail, with current references. The importance of patient mobilization is emphasized. The advantages of chest physical therapy over therapeutic bronchoscopy also are discussed. Two patient examples are used to demonstrate the beneficial effects that may be obtained with chest physical therapy. Following the removal of retained secretions, arterial oxygenation and partial pressure of arterial oxygen/fraction of inspired oxygen concentration ratios improved, and atelectasis resolved without the negative hemodynamic side effects of therapeutic bronchoscopy. Physical therapists trained in the ICU can safely perform chest physical therapy with the majority of patients who are critically ill.
Computerized Tomography Using Video Recorded Fluoroscopic Images (1977)

In this paper we investigate the possibility of constructing computerized tomograms using data collected from a fluoroscopic system. It is shown that through proper handling of these data, useful images can be obtained. The system offers the advantages of eliminating the need for a highly stabilized, linear translating mechanism, and also of requiring relatively low patient dosage. In addition, the data gathering can be done in essentially real time.
RB Reversibly Inhibits DNA Replication via Two Temporally Distinct Mechanisms (2004)

The retinoblastoma (RB) tumor suppressor is a critical negative regulator of cellular proliferation. Repression of E2F-dependent transcription has been implicated as the mechanism through which RB inhibits cell cycle progression. However, recent data have suggested that the direct interaction of RB with replication factors or sites of DNA synthesis may contribute to its ability to inhibit S phase. Here we show that RB does not exert a cis-acting effect on DNA replication. Furthermore, the localization of RB was distinct from replication foci in proliferating cells. While RB activation strongly attenuated the RNA levels of multiple replication factors, their protein expression was not diminished coincident with cell cycle arrest. During the first 24 h of RB activation, components of the prereplication complex, initiation factors, and the clamp loader complex (replication factor C) remained tethered to chromatin. In contrast, the association of PCNA and downstream components of the processive replication machinery was specifically disrupted. This signaling from RB occurred in a manner dependent on E2F-mediated transcriptional repression. Following long-term activation of RB, we observed the attenuation of multiple replication factors, the complete cessation of DNA synthesis, and impaired replicative capacity in vitro. Therefore, functional distinctions exist between the "chronic" RB-mediated arrest state and the "acute" arrest state. Strikingly, attenuation of RB activity reversed both acute and chronic replication blocks. Thus, continued RB action is required for the maintenance of two kinetically and functionally distinct modes of replication inhibition.
Biosensors for Protein Detection: A Review (2005)

Abstract There is considerable demand for the rapid low‐cost determination of proteins, particularly in the food and beverage industry. The most widely used tests are based on colorimetric procedures in which proteins react to produce colored complexes. These methods (Lowry et al. 1951; Bradford 1976; Gornall et al. 1949; Smith et al. 1985) are dependent upon a number of factors other than absolute protein quantity, including amino acid composition, protein purity, and association state. The successful application of these methods relies on using representative calibration standards. Time‐consuming and complex methodologies such as the Kjeldahl technique and quantitative amino acid analysis procedures have been also reported. Apart from these methods, biosensors are interesting tools offering certain operational advantages over standard photometric methods, notably with respect to rapidity, ease‐of‐use, cost, simplicity, portability, and ease of mass manufacture. By appropriate recognition element selection, it is possible to detect either a particular target protein or a broad range of proteins. This review presents an overview of the different biological recognition elements and the various transduction systems that have been reported in the literature to design biosensors for protein detection. Examples are given to illustrate the different possibilities. It must be noticed that this review reports detection of proteins in solution and not proteins immobilized on membranes. Briefly, immobilized proteins can be detected by antibodies (Western blotting) or oligonucleotides such as aptamers (“Eastern blotting”) bearing reporter molecules, fluorescently labeled or radiolabeled.
A live-attenuated and an inactivated chimeric porcine circovirus (PCV)1-2 vaccine are both effective at inducing a humoral immune response and reducing PCV2 viremia and intrauterine infection in female swine of breeding age. (2014)

The objective of this pilot study was to determine the efficacy of inactivated (1 or 2 dose) and live-attenuated chimeric porcine circovirus (PCV)1-2 vaccines in sows using the PCV2-spiked semen model. Thirty-five sows were randomly divided into 6 groups: negative and positive controls, 1 dose inactivated PCV1-2 vaccine challenged (1-VAC-PCV2), 2 dose inactivated PCV1-2 vaccine challenged (2-VAC-PCV2), 1 dose live-attenuated PCV1-2 vaccine unchallenged (1-LIVE-VAC), and 1 dose live-attenuated PCV1-2 vaccine challenged (1-LIVE-VAC-PCV2). The inactivated PCV1-2 vaccine induced higher levels of PCV2-specific antibodies in dams. All vaccination strategies provided good protection against PCV2 viremia in dams, whereas the majority of the unvaccinated sows were viremic. Four of the 35 dams became pregnant: a negative control, a positive control, a 2-VAC-PCV2 sow, and a 1-LIVE-VAC-PCV2 sow. The PCV2 DNA was detected in 100%, 67%, and 29% of the fetuses obtained from the positive control, inactivated vaccinated, or live-attenuated vaccinated dams, respectively. The PCV2 antigen in hearts was only detectable in the positive control litter (23% of the fetuses). The PCV1-2 DNA was detected in 29% of the fetuses in the litter from the 1-LIVE-VAC-PCV2 dam. Under the conditions of this pilot study, both vaccines protected against PCV2 viremia in breeding age animals; however, vertical transmission was not prevented.
A novel micellar synthesis and photophysical characterization of water-soluble acrylamide-styrene block copolymers (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel micellar synthesis and photophysical characterization of water-soluble acrylamide-styrene block copolymersKenneth C. Dowling and J. K. ThomasCite this: Macromolecules 1990, 23, 4, 1059–1064Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/ma00206a025https://doi.org/10.1021/ma00206a025research-articleACS PublicationsRequest reuse permissionsArticle Views687Altmetric-Citations153LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ventriculostomy-related Infections: A Critical Review of the Literature (2002)

Categorizing suspected cerebrospinal fluid infections as contaminants, colonization, suspected or confirmed VRIs, or ventriculitis more accurately describes the patient's clinical condition and may indicate different management strategies. A prospective, randomized clinical trial is required to further evaluate the efficacy of prophylactic catheter exchange in limiting the incidence of VRIs during prolonged catheterization. Although prophylactic catheter exchange remains a practice option, the available data suggest that this procedure is not currently justified.
An approach to nonlinear feedback control with applications to robotics (1983)

http://deepblue.lib.umich.edu/bitstream/2027.42/5060/5/bac2762.0001.001.pdf
LiF:Mg,Cu,P Based Environmental Dosemeter and Dose Calculation Algorithm (1999)

Journal Article LiF:Mg,Cu,P Based Environmental Dosemeter and Dose Calculation Algorithm Get access O.R. Perry, O.R. Perry Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Moscovitch, M. Moscovitch Search for other works by this author on: Oxford Academic PubMed Google Scholar K.J. Velbeck, K.J. Velbeck Search for other works by this author on: Oxford Academic PubMed Google Scholar J.E. Rotunda J.E. Rotunda Search for other works by this author on: Oxford Academic PubMed Google Scholar Radiation Protection Dosimetry, Volume 85, Issue 1-4, 1 September 1999, Pages 273–281, https://doi.org/10.1093/oxfordjournals.rpd.a032851 Published: 01 September 1999
Hierarchically Porous Monolithic LiFePO<sub>4</sub>/Carbon Composite Electrode Materials for High Power Lithium Ion Batteries (2009)

A novel method for the preparation of hierarchically porous LiFePO4 electrode materials for lithium ion batteries has been investigated. A meso/macroporous carbon monolith, a conductive framework, was prepared and infiltrated with the LiFePO4 precursors to increase the electrode/electrolyte interface and improve the rate capability of the battery. The final LiFePO4/carbon monoliths feature a meso/macroporous hierarchical structure. The monoliths were calcined at increasing temperatures, from 650 to 800 °C, to determine the structural and sintering effects on the electrochemical properties of the materials. The samples were characterized using SEM, TEM, nitrogen sorption, and XRD analysis prior to electrochemical testing. The results showed that the capacity of the LiFePO4/carbon electrodes achieved 82% of the theoretical capacity at 0.1C discharge rate.
TWO METHODS FOR CONTINUOUS MONITORING OF HARMONIC DISTORTION IN VIBROSEIS SIGNALS<sup>1</sup> (1989)

ABSTRACT The quality of Vibroseis survey data can be improved by continuously monitoring the vibrator's baseplate and reaction mass accelerations. Equipment failures can be detected as they occur, rather than relying on similarity trials at the beginning and end of the day's production. Equipment faults can then be corrected as they happen and thus would not have a detrimental effect on the quality of the survey data. Source efficiency can be optimized by monitoring the amount of harmonic distortion generated by the vibrator at different drive levels on the different surfaces which may be encountered during a survey. Phase problems introduced by poor coupling of the baseplate to the ground can also be identified and addressed in the field. Rapid analysis of vibrator signals is required if continuous monitoring is to be useful. Frequency‐time ( f‐t ) analyses of vibrator signals are often used in processing centres, but are slow and require a large storage capacity which makes the technique unsuitable for a field analysis system. The two methods proposed to analyse vibrator signals entail the use of hodograms and time‐varying notch filters. Hodograms provide a qualitative analysis of harmonic distortion and vibrator performance. A fast, time‐varying notch filter gives quantitative and qualitative information about the harmonic distortion present in the signal and can be used to identify problems with vibrator behaviour. Both the hodogram and fast, time‐varying notch filter methods can analyse the vibrator's reaction mass and baseplate accelerations as it progresses through its sweep and can present automatically interpreted results to the operator before moving to the next vibrator point.
Exudative Lung Injury Is Associated With Decreased Levels of Surfactant Proteins in a Rat Model of Meconium Aspiration (1997)

Our study suggests that the exudative lung injury with meconium instillation is associated with decreased levels of SP-A and SP-B in the large aggregate fraction of lung surfactant. We speculate that decreased secretion and/or increased degradation accounts for lower levels of SP-B in bronchoalveolar lavage fluid.
Guidelines for the Registration of Two Coordinate Frames (2016)

Certain commercial entities, equipment, or materials may be identified in this document in order to describe an experimental procedure or concept adequately.Such identification is not intended to imply
Spouting of mixed particle‐size beds (1964)

Abstract A systematic experimental study of the minimum spouting velocity of materials with wide and narrow size ranges, mean particle diameters from 0.0134 to 0.104 inches and solids density from 65.8 to 246.3 lb. m /ft. 3 has been carried out in a 6‐in. column with four inlet sizes at different bed heights. A new correlation is presented in which the standard deviation of experimental from calculated minimum spouting velocity is 6.87%. Some qualitative conclusions on spoutability, segregation, attrition and electrostatic effects have been presented.
Improvement in Wear Resistance of High‐Strength and High‐Toughness Silicon Nitride Modified by Ion Implantation (2004)

Surface modification by ion implantation has been conducted to improve the tribological properties of a high‐strength and high‐fracture‐toughness unidirectionally aligned silicon nitride (UA‐SN). B + , N + , Si + , and Ti + ions were implanted into the planes parallel and normal to the grain alignment of the UA‐SN with a fluence of 2 × 10 17 ions/cm 2 at an energy of 200 keV. The ion implanted UA‐SN showed a dramatic improvement in wear resistance. For example, the specific wear rate of the Si + ‐implanted specimen in the direction parallel to the grain alignment was reduced to a value of 3 × 10 −10 mm 2 /N, equal to 1/20 of the unimplanted one. Cross‐sectional transmission electron microscopy indicates the high wear resistance was attributed to the amorphous surface caused by the ion implantation.
Population dynamics and morphometries of <i>Gammarus pulex L.</i>: evidence of seasonal food limitation in a freshwater detritivore (1988)

SUMMARY. 1. Seasonal changes in population size structure of Gammarus pulex L. in a Cotswold stream appeared to indicate a growth check in late summer. 2. The relationships between dry weight and body length, and between the number of primary flagellar segments on the first antenna and either dry weight or body length provided further evidence of a reduction in growth in mid and late summer. 3. Body fat content was minimal (4% of dry weight) at the end of summer, when large particulate organic detritus was scarce or of poor quality, and maximal in late winter (17.9% dry weight in females; 9.4% in males), after a period of high food availability. In a field experiment, the fat content of animals in summer was raised to levels typical of winter by providing high quality food. 4. Field and experimental evidence together strongly infer that this population of G. pulex was subject to severe food limitation from early summer until leaf fall in autumn.
Combined therapy with the RANKL inhibitor RANK-Fc and rhApo2L/TRAIL/dulanermin reduces bone lesions and skeletal tumor burden in a model of breast cancer skeletal metastasis (2010)

In bone metastases, tumor cells interact with the bone microenvironment to induce osteoclastogenesis, leading to bone destruction and the growth factor release. RANK ligand (RANKL) is essential for osteoclast formation, function, and survival. Tumor cell-mediated osteolysis is thought to occur ultimately via induction of RANKL within the bone stroma, and inhibition of RANKL in models of breast cancer bone metastases blocks tumor-induced osteolysis and reduces skeletal tumor burden. In addition, the skeleton is co-opted by tumor cells and functions as a supportive tumor microenvironment. Inhibition of RANKL, by reducing tumor-induced osteoclastogenesis, may reduce the local release of growth factors and calcium which may potentially enhance the anti-tumor activity of cytotoxic or direct tumor apoptotic agents. Recombinant human Apo2 ligand/ TNF-related apoptosis-inducing ligand (rhApo2L/TRAIL/dulanermin) is a dual pro-apoptotic receptor agonist that preferentially induces apoptosis in cancer cells versus normal cells. We therefore examined RANKL inhibition (using RANK-Fc) in combination with rhApo2L/TRAIL on tumor-induced osteolysis and skeletal tumor burden in a murine intracardiac injection model of MDA-MB-231 breast carcinoma bone metastasis. rhApo2L/TRAIL treatment resulted in a rapid reduction of skeletal tumor burden. Treatment with RANK-Fc prevented osteolytic lesions and reduced skeletal tumor burden. Combining RANK-Fc with rhApo2L/TRAIL was superior to either rhApo2L/TRAIL or RANK-Fc alone at reducing skeletal tumor burden in the bone metastasis model. Our findings show that RANKL inhibition effectively inhibits pathologic osteolysis induced by human breast adenocarcinoma MDA-MB-231 cells in animals with established tumors, and also enhances the ability of rhApo2L/TRAIL to reduce skeletal tumor burden in vivo.