gebhart/patrepeval huggingface dataset:
Hydrogenolysis of n-Butane on Supported Ruthenium (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogenolysis of n-Butane on Supported RutheniumJ. C. Kempling and R. B. AndersonCite this: Ind. Eng. Chem. Process Des. Dev. 1970, 9, 1, 116–120Publication Date (Print):January 1, 1970Publication History Published online1 May 2002Published inissue 1 January 1970https://pubs.acs.org/doi/10.1021/i260033a021https://doi.org/10.1021/i260033a021research-articleACS PublicationsRequest reuse permissionsArticle Views117Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Fabry disease: twenty-three mutations including sense and antisense CpG alterations and identification of a deletional hot-spot in the α-galactosidase A gene (1994)

Fabry disease, an X-linked inborn error of glycosphingolipid catabolism, results from mutations in the alpha-galactosidase A gene at Xq22.1. To determine the nature and frequency of the molecular lesions causing the classical and milder variant Fabry phenotypes, and for precise carrier detection in Fabry families, the alpha-galactosidase A coding and flanking intronic sequences from 23 unrelated Fabry hemizygotes were analyzed. In patients with the classic phenotype, 16 new missense and nonsense mutations and four small exonic gene rearrangements were identified: C52S, C56F, E59K, L89R, R100K, R112H, L131P, A143P, G144V, C172Y, D244N, N272K, A288D, W81X, Q99X, Q157X, R301X, 25del1, 333del18, 358del6, and 1020del1. The R112H mutation at a CpG dinucleotide resulted in residual activity and a mild variant phenotype while the R112C lesion caused the classic disease manifestations, defining a genotype/phenotype correlation for sense and antisense mutations at the same CpG dinucleotide. In addition, two complex rearrangements, each involving two mutational events, occurred in classic hemizygotes. Both rearrangements resulted in missense mutations that did not change the reading frame. Notably, three of the deletions occurred within 11 codons in exon 2, thereby defining a 'hot-spot' for deletions. These studies revealed that most mutations in the alpha-galactosidase A gene causing Fabry disease were private, that codons 111-122 defined a deletion hot-spot, and that different substitutions of the same codon resulted in markedly different disease phenotypes.
New cyclodextrin dimers and trimers capable of forming supramolecular adducts with shape-specific ligands (2008)

Bridged cyclodextrin dimers and trimers, in which respectively two and three hydrophobic cavities lie in close proximity, display much higher binding affinities and molecular selectivities than do parent cyclodextrins (CDs). By joining betaCD units with links inserted at different positions (2-2', 3-2', 6-2' or 6-2'-6'') and interposing spacers of different lengths and shapes, multicavity structures can be synthesized that are precisely tailored to fit specific guest molecules. This enzyme-mimicking strategy can also be used to generate stable supramolecular adducts. A series of CD dimers and trimers was prepared in good yields by carrying out the critical synthetic steps under power ultrasound (US) or microwave (MW) irradiation. Starting from azide and acetylenic CD derivatives, we exploited an efficient MW-promoted Huisgen 1,3-dipolar cycloaddition in the presence of Cu(I) salts. The resulting bridged CD derivatives gave stable adducts with magnetic-resonance-imaging contrast agents (MRI CAs) containing gadolinium(III) chelates. These inclusion complexes were found to be 2 to 3 orders of magnitude more stable than those formed by betaCD and to be endowed with high relaxivity values.
A comprehensive review of biomarkers in psoriasis (2009)

Psoriasis is a common, chronic skin disorder, the pathogenesis of which is incompletely understood. Results from various clinical and experimental studies indicate that psoriasis is a complex, multifactorial disease with a genetic predisposition. Factors such as climate, physical trauma, drug, stress and infections (Streptococcus, human immunodeficiency virus) are known to trigger psoriasis. The success of treatment of psoriasis with T-cell depletion and antitumour necrosis factor (TNF)-alpha treatment is explained by the involvement of T cells and TNF- alpha in the pathogenesis of psoriasis. The biochemical basis for the pathogenesis of psoriasis can be attributed to both overexpression and underexpression of certain proteins in psoriatic lesions. The anomalies in protein expression can be classified as abnormal keratinocyte differentiation, keratinocyte hyperproliferation and inflammation. Oxidative stress (OS) and increased free-radical generation have been linked to skin inflammation in psoriasis. The review presents evidence for various markers of psoriasis that can be targeted for effective treatment, including biomarkers of inflammation, keratinocyte hyperproliferation and abnormal differentiation, and stress.
Protein Structure Refinement Using <sup>13</sup>Cα Chemical Shift Tensors (2009)

We have obtained the (13)C alpha chemical shift tensors for each amino acid in the protein GB1. We then developed a CST force field and incorporated this into the Xplor-NIH structure determination program. GB1 structures obtained by using CST restraints had improved precision over those obtained in the absence of CST restraints and were also more accurate. When combined with isotropic chemical shifts, distance, and vector angle restraints, the root-mean squared error with respect to existing X-ray structures was better than approximately 1.0 A. These results are of broad general interest since they show that chemical shift tensors can be used in protein structure refinement, improving both structural accuracy and precision, opening up the way to accurate de novo structure determination.
Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow–derived cells (2004)

Ischemia is a known stimulus for vascular growth. Bone marrow (BM)-derived endothelial progenitor cells (EPCs) are believed to contribute to new blood vessel growth, but the mechanism for this contribution is unknown. To elucidate how BM cells are able to form new blood vessels, a novel murine model of soft tissue ischemia was developed in lethally irradiated mice with BM reconstituted from either tie2/lacZ or ROSA/green fluorescent protein (GFP) mice (n = 24). BM-derived EPCs were recruited to ischemic tissue within 72 hours, and the extent of recruitment was directly proportional to the degree of tissue ischemia. At 7 days, there were persistently elevated levels of vascular endothelial growth factor (VEGF) (2.5-fold) and circulating VEGF receptor-2/CD11(-) (flk-1(+)/CD11(-)) cells (18-fold) which correlated with increased numbers of BM-derived EPCs within ischemic tissue. The cells were initially located extravascularly as proliferative clusters. By day 14, these clusters coalesced into vascular cords, which became functional vessels by day 21. In vitro examination of human EPCs from healthy volunteers (n = 10) confirmed that EPC proliferation, adhesion, and chemotaxis were all significantly stimulated in hypoxic conditions. We conclude that BM-derived cells produce new blood vessels via localized recruitment, proliferation, and differentiation of circulating cells in a sequence of events markedly different from existing paradigms of angiogenesis.
Research on structural innovation of intelligent tree planting robot (2023)

This paper introduces an intelligent tree-planting robot, which belongs to the technical field of agricultural and forestry machinery and equipment, and the innovative features of its structure are hollow rotary drill and seedling storage and delivery device. This tree planting robot realizes the integration of autonomous movement, drilling, seedling delivery, mulching, compaction and watering functions, with a coherent workflow, which greatly improves the efficiency of tree planting. This robot will replace the traditional manual tree planting, greatly improve the survival rate of seedling planting and reduce labor cost.
Automatic registration of LiDAR and optical imagery using depth map stereo (2014)

Automatic fusion of aerial optical imagery and untextured LiDAR data has been of significant interest for generating photo-realistic 3D urban models in recent years. However, unsupervised, robust registration still remains a challenge. This paper presents a new registration method that does not require priori knowledge such as GPS/INS information. The proposed algorithm is based on feature correspondence between a LiDAR depth map and a depth map from an optical image. Each optical depth map is generated from edge-preserving dense correspondence between the image and another optical image, followed by ground plane estimation and alignment for depth consistency. Our two-pass RANSAC with Maximum Likelihood estimation incorporates 2D-2D and 2D-3D correspondences to yield robust camera pose estimation. Experiments with a LiDAR-optical imagery dataset show promising results, without using initial pose information.
Gaslift Optimization - Claymore Field (1983)

ABSTRACT The Claymore field has been developed with a single 36-slot integrated platform. Wells drilled from the platform are deviated up to 70° to reach reservoirs in the Lower Cretaceous Sands, the Upper Jurassic Claymore Sands, the Zechstein Limestones and Dolomites and the Carboniferous Sands. Produced fluids from the reservoirs vary considerably in PVT properties, but are all of the low-GOR type. Gaslift was selected as the artificial-lift system for the field and compressors were installed with a total throughput of 200 MMSCF/D at a discharge pressure of 1,600 psig. Wells are typically completed with 5-1/2" plastic-coated, premium threaded tubing equipped with side-pocket gaslift mandrels. The gaslift design and mandrel spacing are based on 12,000 BF/D with a 50% watercut using up to 10 MSCF/D of gaslift gas. Because of the high gas rates needed, dual-valve stations (two mandrels one joint apart) are used. Fig. 1 shows such a well completion.
“世界模式”和人的形象——罗马俱乐部思想批判 (1983)

罗马俱乐部是一个非官方的组织,约有100名各国学者参加,它出现于六十年代末。这个组织的出现,是对全世界发生的社会、经济、能源等变化过程及其积极的和消极的后果的一种反映。自罗马俱乐部成立以来,多国学者小组为它提出过10个报告(关于世界的现状及其变化,关于人类发展的可能的抉择,以及拟议中的有助于摆脱危机局面和解决人类面临的各种全球性问题)。第十一个报告专门研究“人的质量”情况,即将发表。罗马俱乐部的方案既不同于过去和现在的各种乌托邦和迪斯托邦(非理想国),也不同于现代未来学的预测,它们不依靠抽象的结构,而是依靠揭示人
Electrical field-flow fractionation in particle separation. 1. Monodisperse standards (1993)

In its original implementation, electrical field-flow fractionation (EFFF) was carried out in membrane-walled channels with the electrodes placed externally to the flow channel. The poor separation efficiency of this system left the technique largely unattended for about two decades. In the present study, we describe a new and simple approach to EFFF, which demonstrates the technique's ability to carry out rapid, high-resolution separations of colloidal samples in aqueous suspensions. The present channels are bounded by the smooth and rigid graphite electrodes which allow for the application of small voltages, typically less than 2 V, across the thin (178 microns) separation space defined by a Mylar spacer. Although this arrangement generates nominal fields of the order of 100 V/cm, polarization of the electrodes considerably reduces the effective field across the bulk of the channel to less than 1% of the nominal value. Nevertheless, under conditions of low ionic strength the system is shown to retain and separate polystyrene (PS) latex standards with sizes ranging from 60 to 10,000 nm. For small particles of comparable zeta-potential, separating in the "normal" mode of EFFF, the size selectivity Sd, is approximately 0.7. As with other FFF techniques, EFFF displays a transition from "normal" to "steric" behavior; the critical diameter for this transition is highly dependent on ionic strength, with values ranging from approximately 500 nm in deionized water to approximately 1200 nm in 133 microM aqueous NaCl under an applied voltage of 1.37 V and a flow of 1 mL/min.(ABSTRACT TRUNCATED AT 250 WORDS)
Novel mechanisms of Escherichia coli succinyl-coenzyme A synthetase regulation (1996)

Low concentrations of ADP are shown to increase the rate of phosphoenzyme formation of E. coli succinyl-coenzyme A (CoA) synthetase (SCS) without altering the fraction of phosphorylated enzyme. This is true when either ATP or succinyl-CoA and Pi are used to phosphorylate the enzyme. The stimulatory effect of ADP is not altered by sample dilution, is retained upon partial purification of the enzyme, and reflects the binding of ADP to a site other than the catalytic site. GDP also alters the phosphorylation of the E. coli SCS but does so primarily by enhancing the level of the phosphoenzyme and only when ATP is used as the phosphate donor. GDP appears to function by neutralizing the action of a specific inhibitory protein. This inhibitor of SCS allows for interconversion of succinate and succinyl-CoA in a manner dissociated from changes in ATP-ADP metabolism. These previously unidentified and varied mechanisms by which SCS is regulated focus attention on this enzyme as an important control point in determining the cell's potential to meet its metabolic demands.
COVID-19: fighting the invisible enemy with microRNAs (2020)

This review highlighted the importance of various miRNAs and their potential role in fighting with this pandemic as therapeutic molecules utilizing nanotechnology.
Study on fermentation conditions of palm juice vinegar by response surface methodology and development of a kinetic model (2012)

Natural vinegar is one of the fermented products which has some potentiality with respect to a nutraceutical standpoint. The present study is an optimization of the fermentation conditions for palm juice vinegar production from palm juice (Borassus flabellifer) wine, this biochemical process being aided by Acetobacter aceti (NCIM 2251). The physical parameters of the fermentation conditions such as temperature, pH, and time were investigated by Response Surface Methodology (RSM) with 2³ factorial central composite designs (CCD). The optimum pH, temperature and time were 5.5, 30 °C and 72 hrs for the highest yield of acetic acid (68.12 g / L). The quadratic model equation had a R² value of 0.992. RSM played an important role in elucidating the basic mechanisms in a complex situation, thus providing better process control by maximizing acetic acid production with the respective physical parameters. At the optimized conditions of temperature, pH and time and with the help of mathematical kinetic equations, the Monod specific growth rate ( µ max= 0.021 h-1), maximum Logistic specific growth rate ( µ 'max = 0.027 h-1) and various other kinetic parameters were calculated, which helped in validation of the experimental data. Therefore, the established kinetic models may be applied for the production of natural vinegar by fermentation of low cost palm juice.
Actinic keratoses (2009)

In the current study, the authors quantified the malignant potential of clinically diagnosed AKs for both SCC and BCC, although many did not persist, and the results suggested that AKs may play a greater role in the overall burden of keratinocyte carcinomas than previously documented.
Stimulated Raman scattering of polymer nanoparticles for multiplexed live-cell imaging (2017)

A novel nanoparticle-based imaging strategy is introduced that couples biocompatible organic nanoparticles and stimulated Raman scattering (SRS) microscopy. Polymer nanoparticles with vibrational labels incorporated were readily prepared for multi-color SRS imaging with excellent photo-stability. The Raman-active polymer dots are nontoxic, rapidly enter various cell types, and are applied in multiplexed cell-type sorting.
Bridging two worlds with RICE (2011)

The growing need to use large amounts of data as the basis for sophisticated business analysis conflicts with the current capabilities of statistical software systems as well as the functions provided by most modern databases. We developed two novel approaches towards a solution for this basic conflict, based on the widely-used statistical software package R and the SAP In-Memory Computing Engine (IMCE). We thereby propose an alternative data exchange mechanism with R. Instead of using standard SQL interfaces like JDBC or ODBC we introduced SQL-SHM, a shared memory-based data exchange to incorporate R's vertical data structure. Furthermore, we extended this approach to R-Op introducing R scripts equivalent to native database operations like join or aggregation within the execution plans. With the calculation engine, IMCE provides a framework to model logical execution plans and thereby offers a convenient way to use the full functionality of R via SQL interface. Moreover, this enables us to run R scripts in parallel without the necessity of extending the R interpreter itself.
Regulation of F-Actin Stability in Dendritic Spines by Glutamate Receptors and Calcineurin (1998)

Neuronal degeneration and cell death can result from excessive activation of receptors for the excitatory neurotransmitter glutamate; however, the very earliest changes in cytoskeletal organization have not been well documented. We have used an in vitro model system to examine the early consequences of intense glutamate receptor activation on dendritic spine synapses. Cultured hippocampal neurons exposed to NMDA for as little as 5 min exhibited a rapid and extensive loss of dendritic spines. Staining for the presynaptic marker synapsin 1 and the postsynaptic density proteins PSD-95 and the NR1 subunit of NMDA receptors remained intact. The disappearance of spines was accompanied by a selective loss of filamentous actin staining at synapses. The NMDA-induced loss of spine actin was time- and concentration-dependent and blocked by NMDA receptor antagonists. The effect was mimicked by L-glutamate, AMPA, and ionomycin but not by agonists of L-type calcium channels or of metabotropic glutamate receptors. The effect of NMDA on local actin assembly was strongly attenuated by pretreatment with an actin stabilizing compound or by an antagonist of the calcium-dependent protein phosphatase calcineurin. Immunoreactivity for calcineurin was enriched at synapses together with F-actin. These results indicate that the actin-mediated stability of synaptic structure is disrupted by intense glutamate receptor activity and that calcineurin blockers may be useful in preventing such destabilization.
[Effects of decitabine on biological behavior of U266 cells]. (2011)

This study was aimed to explore the effects of decitabine on the biological behaviour of U266 cells in vitro so as to provide a new thinking and experiment basis, as well as new evidences for the pathogenesis of multiple myeloma. MTT and colony formation assays were used to evaluate the impact of decitabine on the ability of proliferation of U266 cells; flow cytometry was used to analyze the cell distribution in cell cycle; transwell chamber and matrigel assays were used to observe the ability of migration and invasion. The results indicated that decitabine could significantly suppress the proliferation of U266 cells in time-and dose-dependent manners. The flow cytometric analysis demonstrated that the cells in G(0)-G(1) phase significantly increased while the cells in S and G(2)/M phase decreased. The migration and matrigel invading tests showed that the number of cells moving into under chamber of transwell decreased after U266 cells treated with decitabine. It is concluded that decitabine may act as an effective drug for MM by inhibiting the proliferation, migration and invasion ability, and the specific mechanism needs to be deeply explored.
Disruption of <i>mCry2</i> restores circadian rhythmicity in <i>mPer2</i> mutant mice (2002)

Many biochemical, physiological, and behavioral processes display daily rhythms generated by an internal timekeeping mechanism referred to as the circadian clock. The core oscillator driving this clock is located in the ventral part of the hypothalamus, the so called suprachiasmatic nuclei (SCN). At the molecular level, this oscillator is thought to be composed of interlocking autoregulatory feedback loops involving a set of clock genes. Among the components driving the mammalian circadian clock are the Period 1 and 2 (mPer1 and mPer2) and Cryptochrome 1 and 2 (mCry1 and mCry2) genes. A mutation in the mPer2 gene leads to a gradual loss of circadian rhythmicity in mice kept in constant darkness (DD). Here we show that inactivation of the mCry2 gene in mPer2 mutant mice restores circadian rhythmicity and normal clock gene expression patterns. Thus, mCry2 can act as a nonallelic suppressor of mPer2, which points to direct or indirect interactions of PER2 and CRY2 proteins. In marked contrast, inactivation of mCry1 in mPer2 mutant mice does not restore circadian rhythmicity but instead results in complete behavioral arrhythmicity in DD, indicating different effects of mCry1 and mCry2 in the clock mechanism
New Water‐Soluble Contrast Enhancing Material for I‐Line Lithography (1989)

A new water‐soluble contrast enhancing material (CEM) has been developed for use with i‐line (365 nm) lithography. The CEM is composed of poly (p‐styrene sulfonic acid), p‐morpholinobenzene diazonium chloride zinc chloride salt and deionized water. The poly (p‐styrene sulfonic acid) effectively prevents degradation of the diazonium salt in water and therefore stabilizes the formulation. Resolutions of 0.5 μm are demonstrated Using conventional photoresist with the water‐soluble CEM. The method is easy to use compared to earlier contrast enhancing materials, in that no barrier coating or special stripping of the CEM is required.
Content-Based Image Retrieval using Metadata and Relaxation Techniques. (1998)

In this chapter, a metadata approach is proposed for content-based image retrieval. A three-layered data model is introduced which consists of a Representation Layer (RL), a Semantic Layer (SL), and a Knowledge Layer (KL). Raw images and segmented objects (represented in contours) are represented in the RL. Hierarchical, spatial, temporal, and evolutionary semantics of the image content are captured in the SL. This layer mimics the user&apos;s conceptual view of the image content. Shape model(s) and decomposition techniques are introduced for extracting features for differently shaped image objects. Knowledge of image feature characteristics is presented in the KL. An instance-based conceptual clustering technique is used to cluster conceptually similar image objects and features. A hierarchical knowledge representation, called type abstraction hierarchy, is used to represent the clustering of similar images based on a common set of features. A knowledge-based spatial evolutionary query lan...
Vilsmeier Reaction of Phenols. I. Synthesis of Aryl Formates (1977)

Abstract The reaction of phenol and o-t-butylphenols with N,N-dimethylformamide–phosphoryl chloride complex in dimethylformamide afforded the corresponding formates in fairly good yields. The scope and limitation of o-formylation of highly sterically hindered phenols with the complex were also examined.