gebhart/patrepeval huggingface dataset:
Structure-function analysis of three cAMP-independent forms of the cAMP receptor protein. (1986)

cAMP receptor protein (CRP)-dependent operon expression in Escherichia coli requires the CRP X cAMP complex form of wild-type CRP. One class of crp mutants (crp*) activates CRP-dependent promoters in strains (cya) incapable of endogenous cAMP synthesis. Of fundamental interest is the difference in regulatory properties exhibited by crp* mutant strains, some of which exhibit glucose-mediated repression of beta-galactosidase synthesis, some of which do not. To gain a better understanding of the mechanisms of cAMP-independent promoter activation and repression we have: determined through cloning and DNA sequence analysis the primary structure of three CRP* forms of CRP; purified the mutant proteins; characterized the effect of these mutations on CRP secondary structure; and studied CRP*-activated lac promoter regulation in a purified in vitro transcription system. The results of this study provide strong evidence that mutations in crp alter the conformation of CRP and result in cAMP-independent activation of CRP-dependent promoters in vitro. In addition, a CRP allele-specific inhibition of CRP* activity by spermidine was observed in vitro that parallels crp* strain-specific sensitivity to glucose-mediated repression of CRP-dependent enzyme synthesis in vivo. This observation provides evidence that catabolite repression in cells lacking cAMP may be mediated through a mechanism that inhibits CRP* activity.
Tetrabutylammonium hydroxide: a reagent for the base-catalyzed dehydration of vicinal dihydrodiols of aromatic hydrocarbons. Implications to ion-pair chromatography (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTetrabutylammonium hydroxide: a reagent for the base-catalyzed dehydration of vicinal dihydrodiols of aromatic hydrocarbons. Implications to ion-pair chromatographyDavid W. McCourt, Peter P. Roller, and Harry V. GelboinCite this: J. Org. Chem. 1981, 46, 21, 4157–4161Publication Date (Print):October 1, 1981Publication History Published online1 May 2002Published inissue 1 October 1981https://pubs.acs.org/doi/10.1021/jo00334a010https://doi.org/10.1021/jo00334a010research-articleACS PublicationsRequest reuse permissionsArticle Views350Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimizing Mobile Prefetching by Leveraging Usage Patterns and Social Information (2014)

Real-time entertainment constitutes the majority of traffic in today's mobile networks. The data volume is expected to increase in the near future, whereas the mobile bandwidth capacity is likely to increase significantly slower. Especially peak hour traffic often leads to overloaded mobile networks and poor user experience. This increases costs for the mobile operator, which has to adapt to the peak demand by capacity over provisioning. The new approach proposed in this paper aims to leverage the user's context and video meta-information to unleash the potential of video prefetching. Based on observed user interactions with social networks, the videos a user consumes from social neighbours can be predicted. Moreover, the user's daily routine even enables a prediction of the time when videos are consumed as well as the network capabilities available at that point. First results show that partial prefetching based on content categories provides a potential for efficiently offloading mobile networks. Additionally, the user experience can be improved as freezing playbacks of videos can be decreased. Initial results show a high potential for category-based prefeching.
Ring-core photonic crystal fiber for propagation of OAM modes (2019)

We propose and fabricate a novel ring-core photonic crystal fiber made of a circular ring core surrounded by a cladding constituted of air holes organized in a first circular ring surrounded by hexagonal ones. The fiber efficiently supports four different groups of orbital angular momentum (OAM) modes. The effective indices of spin-orbit aligned and spin-orbit anti-aligned modes in the same OAM modes group are separated by at least 2.13×10<sup>-3</sup> at 1550 nm. The realized fiber is expected to be a good platform for applications involving OAM modes.
Masking timing errors on speed-paths in logic circuits (2009)

There is a growing concern about timing errors resulting from design marginalities and the effects of circuit aging on speed-paths in logic circuits. This paper presents a low overhead solution for masking timing errors on speed-paths in logic circuits. Error masking at the outputs of a logic circuit is achieved by synthesis of a non-intrusive error-masking circuit that has at least 20% timing slack over the original logic circuit. The error-masking circuit can also be used to collect runtime information when the speed-paths are exercised to (i) predict the onset of wearout and (ii) assist in in-system silicon debug. Simulation results for several benchmark circuits and modules from the OpenSPARC T1 processor are presented to illustrate the effectiveness of the proposed solution. 100% masking of timing errors on all speed-paths within 10% of the critical path delay is achieved for all circuits with an average area (power) overhead of 16% (18%).
Resonant-wavelength tuning of microring filters by oxygen plasma treatment (2005)

The resonant-wavelength tuning of integrated-optic microring filters in silicon nitride using oxygen plasma treatment is demonstrated. During the treatment, high-energy oxygen ions in the plasma enter into the device surface such that the material composition is converted to SiO/sub x/N/sub y/. The corresponding index variation results in a modification of the effective index of the guide mode and, therefore, the tuning of the resonant wavelength of microring filters. The effects of treatment parameters, such as radio-frequency power, oxygen flow rate, and treatment time, on the characteristics of microring filters are discussed. Experimental results show that the resonant wavelengths of microring filters can be effectively tuned over a range larger than their free spectral ranges.
Exterior Reinforced Concrete Beam-to-Column Connections Subjected to Earthquake-Type Loading (1985)

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Temporal Patterns of Growth Hormone, Prolacting and Thyrotropin Secretion in Targhee Rams Selected for Rate and Efficiency of Gain (1983)

Thirteen Targhee rams selected for rate and efficiency of gain for 4 yr (1.5 generations) were compared with 10 rams from a Targhee line with no selection for over 20 yr to determine if selection for these traits would be associated with changes in the secretion of growth hormone (GH), thyrotropin (TSH) and(or) prolactin (PRL). Selected rams exhibited greater birth weight, average daily gain (ADG) and feed consumed/day during a 6-wk individual feeding regimen, and exhibited greater overall ADG during a 16-wk feeding trial as compared with the unselected rams. Temporal blood plasma samples were collected at 15-min intervals for 8 h from each of the 23 rams for hormone analysis. Selected rams exhibited greater overall mean GH (6.1 +/- .4 vs 4.6 +/- .5 ng/ml), overall mean TSH (8.6 +/- 1.2 vs 6.2 +/- .7 ng/ml) and baseline mean TSH (8.0 +/- 1.1 vs 5.6 +/- .5 ng/ml) than the unselected rams. Although the adjusted GH spike amplitude value was higher in the selected line (12.1 +/- 3.0 vs 7.4 +/- .8 ng/ml), this difference was not significant. No differences were observed with any of the variables of PRL secretion. In addition, there were no significant correlations between any of the hormone variables and any of the feed or gain data. These data support the hypothesis that Targhee rams selected for rate and efficiency of gain exhibit higher plasma levels of GH and TSH than unselected rams of the same breed.
Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study (2003)

The extracts (50% ethanolic) of nutmeg and clove enhanced the sexual behaviour of male mice.
Practice and Predicament: The Nationality of the International Arbitrator (With Survey Results) (2007)

Generally speaking, measurement of hydroxylated radical products of salicylic acid requires a fussy separation process. In this study, we describe a simple method to electrochemically detect hydroxyl radicals (*OH) using 4-hydroxybenzoic acid (4-HBA) as the *OH trap. The *OH is generated by the Fenton reaction from iron (II) sulfate and hydrogen peroxide in a phosphate buffer solution. Experimental results show that our method can detect the OH with high sensitivity without any separation process. The differential pulse voltammetric responses show a linear dependence on the concentration of *OH in a range of 2.0x10(-6) and 1.0x10(-3)M with a determination limit down to 5.0x10(-7)M. As a demonstration, the kinetics of the Fenton reaction was mapped by measuring the reaction product of hydroxyl radical trapped by 4-HBA. The result is in good agreement with that reported previously. All the results show that the present approach could provide a simple, inexpensive and promising method for biomedicine and iatrology.
Carbon tetrachloride toxicity as a model for studying free-radical mediated liver injury (1985)

A single dose of CCl4 when administered to a rat produces centrilobular necrosis and fatty degeneration of the liver. These hepatotoxic effects of CCl4 are dependent upon its metabolic activation in the liver endoplasmic reticulum to reactive intermediates, including the trichloromethyl free radical. Positive identification of the formation of this free radical in vivo, in isolated liver cells and in microsomal suspensions in vitro has been achieved by e.s.r. spin-trapping techniques. The trichloromethyl radical has been found to be relatively unreactive in comparison with the secondarily derived peroxy radical CCl3O2., although each free radical species contributes significantly to the biological disturbances that occur. Major early perturbations produced to liver endoplasmic reticulum by exposure in vivo or in vitro to CCl4 include covalent binding and lipid peroxidation; studies of these processes occurring during CCl4 intoxication have uncovered a number of concepts of general relevance to free-radical mediated tissue injury. Lipid peroxidation produces a variety of substances that have high biological activities, including effects on cell division; many liver tumours have a much reduced rate of lipid peroxidation compared with normal liver. A discussion of this rather general feature of liver tumours is given in relation to the liver cell division that follows partial hepatectomy.
MyoD is required for myogenic stem cell function in adult skeletal muscle (1996)

To investigate the function of MyoD in adult skeletal muscle, we interbred MyoD mutant mice with mdx mice, a model for Duchenne and Becker muscular dystrophy. Mice lacking both MyoD and dystrophin displayed a marked increase in severity of myopathy leading to premature death, suggesting a role for MyoD in muscle regeneration. Examination of MyoD mutant muscle revealed elevated numbers of myogenic cells; however, myoblasts derived from these cells displayed normal differentiation potential in vitro. Following injury, MyoD mutant muscle was severely deficient in regenerative ability, and we observed a striking reduction in the in vivo proliferation of myogenic cells during regeneration. Therefore, we propose that the failure of MyoD-deficient muscle to regenerate efficiently is not caused by a reduction in numbers of satellite cells, the stem cells of adult skeletal muscle, but results from an increased propensity for stem-cell self-renewal rather than progression through the myogenic program.
Hierarchical Layouts for Photo Libraries (2006)

We use an annotated digital photo collection to demonstrate a two-level auto-layout technique consisting of a central primary region with secondary regions surrounding it. Because the object sizes within regions can only be changed in discrete units, we refer to them as quantum content. Our real-time algorithms enable a compelling interactive display as users resize the canvas, or move and resize the primary region
The concentration of radioactivity from labeled epinephrine and its precursors in the dog adrenal medulla. (1967)

Summary Twenty-six dogs were injected with 14C labeled epinephrine and its precursors and two different phenylethylamines. One dog was given an 125I labeled phenylethylamine. Blood samples were withdrawn at frequent intervals for the first 6 hours, the urine collected and the dog sacrificed at 6 or 24 hours. Tissue samples were obtained from 16 organs of each dog and the concentration of radioactivity determined and expressed as counts per minute per milligram of tissue. The average adrenal medulla:plasma ratio at 6 hours rose from 20 after 3,4-dihydroxyphenylalanine (dopa) to 740 after 3,4-dihydroxyphenylethylamine (dopamine) and then fell to 128 after norepinephrine and 126 after epinephrine. Similar ratios at 24 hours could not be obtained because of low plasma activity. However, activity concentrations in the adrenal medulla (cpm/mg) were tyrosine 34, dopa 110, dopamine 422, norepinephrine 401, and epinephrine 243. Activity concentrations in the adrenal medulla 6 hours after the administration of 14C labeled p-tyramine and phenylethylamine were low. Rapid deiodination of p-iodophenylethylamine 125I precluded any distribution studies. After dopamine the average adrenal medulla:kidney ratios were 72 and 170 after 6 and 24 hours, respectively. Similarly, adrenal medulla:liver ratios were 90 and 112. The plasma concentration of 14C radioactivity from dopamine fell more rapidly and to lower levels after the first hour than after any other compounds, a more rapid urinary excretion being also found. The concentration of radioactivity from labeled dopamine in the adrenal medulla is higher than the concentrations of 131I in metastases from thyroid cancer. These data suggest that similar studies after administration of labeled dopamine or similar compounds in patients with chromaffin tumors would be of interest.
Influence of Lignosulphonate Molecular Weight Fractions on the Properties of Fresh Cement (1997)

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Human neoplastic B cells express more than two isotypes of immunoglobulins without deletion of heavy-chain constant-region genes. (1987)

Flow cytometric analyses of surface immunoglobulins of human neoplastic B cells from four patients indicated that more than two isotypes were expressed on the surface of each patient's neoplastic B cells. Southern blot analysis of DNAs of these cells showed that each patient's neoplastic cells had the monoclonal rearrangement profile of the J segment of the immunoglobulin heavy-chain gene. Heavy-chain constant-region genes of these cells had no deletion associated with S-S recombination. Northern blot analysis of RNA from two neoplastic cells revealed that each RNA contained comparable amounts of mRNAs for two different isotypes which were identified by surface staining. These results support the hypothesis that the simultaneous expression of two different isotypes in a certain stage of B-cell differentiation is mediated by alternative RNA splicing without DNA deletion.
Swelling of Polystyrene Latex Particles in Water by High-Pressure Carbon Dioxide (1997)

The swelling of a 50 nm monodisperse polystyrene latex by carbon dioxide was measured by dynamic light scattering at 25 °C at pressures up to 35 MPa. At the higher pressures, the polystyrene (PS) latex swelled by up to 1.6 times as much as bulk PS. This enhanced swelling is due largely to the adsorption of CO2 into the interfacial region, which lowers the overall interfacial tension between the latex and water phases. On the basis of this enhanced swelling, the thickness of the interfacial region containing PS, carbon dioxide, and water is approximately 4 nm, which is on the order of the radius of gyration of a PS chain.
Chemical structure of networks resulting from curing of <i>N</i>,<i>N</i>‐diglycidylaniline‐type resins with aromatic amines. II. Detection and characterization of intermolecular etherification on model compounds (1990)

Abstract The reactivity of model compounds representative of the structures resulting from the first steps of curing in uncatalyzed (or LiClO 4 ‐catalyzed) N,N ‐diglycidylaniline/aromatic amine systems was studied. The results indicate that the intermolecular etherification either does not occur or is very slow under these conditions. Moreover, the latter situation is observed only in the very specific configuration when two hydroxyl groups are very close to each other. From these experiments, it can be inferred that the most likely reactions occurring after the epoxy‐primary amine addition in uncatalyzed N,N ‐diglycidylaniline/aromatic amine systems are the are the epoxy‐secondary‐amine addition and the cyclization reactions discussed in a previous paper.
Random walks with “back buttons (2013)

We introduce backoff processes, an idealized stochastic model of browsing on the world-wide web, which incorporates both hyperlink traversals and use of the “back button. ” With some probability the next state is generated by a distribution over out-edges from the current state, as in a traditional Markov chain. With the remaining probability, however, the next state is generated by clicking on the back button, and returning to the state from which the current state was entered by a “forward step”. Repeated clicks on the back button require access to increasingly distant history. We show that this process has fascinating similarities to and differences from Markov chains. In particular, we prove that like Markov chains, backoff processes always have a limit distribution, and we give algorithms to compute this distribution. Unlike Markov chains, the limit distribution may depend on the start state.
The isolation and characterisation of bacteria with the potential to degrade waxes that cause water repellency in sandy soils (2004)

Water repellency in soils is caused by waxy coatings on particles and can seriously limit agricultural production. Bioremediation of these soils, using wax-degrading bacteria isolated from soils and other sources rich in microorganisms, was investigated. Wool wax, a complex mixture of fatty acids and alcohols, was used to select bacteria capable of metabolising hydrophobic compounds. Of the 37 stable isolates, two-thirds were actinomycetes. These organisms are known for their ability to metabolise a wide range of organic compounds. Degradation of waxes associated with soil particles is facilitated by the production of biosurfactants that emulsify hydrophobic compounds. Measurement of biosurfactant production indicated that those isolates that grew best on hydrocarbon were also the most prolific biosurfactant producers. Inoculation of water-repellent soils, under controlled conditions, with the most efficient wax-degrading bacterial isolates resulted in significant improvements in soil wettability.
5′‐(<i>E</i>)‐Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA–GalNAc Conjugates (2016)

Small interfering RNA (siRNA)-mediated silencing requires siRNA loading into the RNA-induced silencing complex (RISC). Presence of 5'-phosphate (5'-P) is reported to be critical for efficient RISC loading of the antisense strand (AS) by anchoring it to the mid-domain of the Argonaute2 (Ago2) protein. Phosphorylation of exogenous duplex siRNAs is thought to be accomplished by cytosolic Clp1 kinase. However, although extensive chemical modifications are essential for siRNA-GalNAc conjugate activity, they can significantly impair Clp1 kinase activity. Here, we further elucidated the effect of 5'-P on the activity of siRNA-GalNAc conjugates. Our results demonstrate that a subset of sequences benefit from the presence of exogenous 5'-P. For those that do, incorporation of 5'-(E)-vinylphosphonate (5'-VP), a metabolically stable phosphate mimic, results in up to 20-fold improved in vitro potency and up to a threefold benefit in in vivo activity by promoting Ago2 loading and enhancing metabolic stability.
An EPROM cell with a magnesium electronic injector (2002)

By using Mg as the tunnelling electrode for an EPROM cell, it is shown in a control experiment that the tunnelling current is much enhanced while the tunnelling field is much reduced after a sintering procedure in which Mg reacts with the SiO/sub 2/ dielectric. Potentially, this may lead to faster programming, lower programming voltages and better programming endurance. An experimental EPROM cell has been made and has demonstrated programmability.
Accommodative Lag before and after the Onset of Myopia (2006)

Substantive and consistent elevations in accommodative lag relative to model estimates of lag in emmetropes did not occur in children who became myopic before the onset of myopia or during the year of onset. Increased accommodative lag occurred in children after the onset of myopia. Elevated accommodative lag is unlikely to be a useful predictive factor for the onset of myopia. Increased hyperopic defocus from accommodative lag may be a consequence rather than a cause of myopia.
A new, asymmetric synthesis of lipids and phospholipids (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new, asymmetric synthesis of lipids and phospholipidsCarmen E. Burgos, Donald E. Ayer, and Roy A. JohnsonCite this: J. Org. Chem. 1987, 52, 22, 4973–4977Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/jo00231a025https://doi.org/10.1021/jo00231a025research-articleACS PublicationsRequest reuse permissionsArticle Views937Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts