gebhart/patrepeval huggingface dataset:
Towards content-based relevance ranking for video search (2006)

Most existing web video search engines index videos by file names, URLs, and surrounding texts. These types of video metadata roughly describe the whole video in an abstract level without taking the rich content, such as semantic content descriptions and speech within the video, into consideration. Therefore the relevance ranking of the video search results is not satisfactory as the details of video contents are ignored. In this paper we propose a novel relevance ranking approach for Web-based video search using both video metadata and the rich content contained in the videos. To leverage real content into ranking, the videos are segmented into shots, which are smaller and more semantic-meaningful retrievable units, and then more detailed information of video content such as semantic descriptions and speech of each shots are used to improve the retrieval and ranking performance. With video metadata and content information of shots, we developed an integrated ranking approach, which achieves improved ranking performance. We also introduce machine learning into the ranking system, and compare them with IR-model (information retrieval model) based method. The evaluation results demonstrate the effectiveness of the proposed ranking methods.
Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice. (1985)

The effect of in vivo treatment with anti-L3T4 monoclonal antibody (mAb) on the course of experimentally-induced cutaneous leishmaniasis was studied in genetically susceptible BALB/c mice. Administration of anti-L3T4 mAb resulted in a pronounced therapeutic effect as reflected by both resolution of lesions and a dramatic reduction in the parasite load in treated mice. This effect was specific for anti-L3T4 mAb and correlated with a selective depletion of L3T4+ T cells in the lymphoid tissues of treated mice. Moreover, both the therapeutic effect of anti-L3T4 mAb on cutaneous leishmaniasis and the concurrent depletion of L3T4+ T cells in the lymphoid tissues of treated mice were dependent upon the isotype of the anti-L3T4 mAb employed.
HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells (1996)

Human hepatocarcinoma-intestine-pancreas (HIP) cDNA, isolated from a hepatocellular carcinoma, encodes a C-type lectin. According to published cDNA sequences, HIP protein is identical to human pancreatitis-associated protein (PAP). In these sequences, a putative signal peptide and the carbohydrate recognition domain (CRD) can be recognized. In the present study, we established transgenic mice to drive the production of soluble recombinant HIP/PAP protein in the milk of lactating animals; using this model, we showed that HIP/PAP protein was secreted after suitable cleavage of the potential signal peptide. Moreover, we also produced HIP/PAP protein by Escherichia coli cultures performed to generate specific antibodies. These antibodies enabled the detection of HIP/PAP protein in normal intestine and pancreas (both in endocrine and exocrine cells), e.g., intestinal neuroendocrine and Paneth cells, pancreatic islets of Langerhans, and acinar cells. HIP/PAP protein was also identified in the cytoplasm of tumoral hepatocytes but not in nontumoral hepatocytes. Finally, HIP/PAP protein activity was tested and we showed that HIP/PAP induced the adhesion of rat hepatocytes and bound strongly to extracellular matrix proteins (laminin-1, fibronectin), less strongly to type I and IV collagen, and not at all to heparan sulfate proteoglycan. In conclusion, these results showed that HIP/PAP protein was matured on secretion. We also demonstrated that HIP/PAP protein was specifically expressed in hepatocarcinoma cells and interacted with rat hepatocytes and the extracellular matrix. Taken overall, these results suggest that HIP/PAP protein may be of potential importance to liver cell differentiation/proliferation.
Drug-carrier property of albumin microspheres in chemotherapy. II. Preparation and tissue distribution in mice of microsphere-entrapped 5-fluorouracil. (1979)

Bovine serum albumin microspheres contatining 5-fluorouracil-6-<SUP>3</SUP>H were prepared by heating at 180° (or 150°, 100°) of 25% albumin solution in cottonseed oil emulsion. The shape of this microsphere was invariably spherical, and the average diameter was 0.66μ. After intravenous injection in mice, 5-fluorouracil-6-<SUP>3</SUP>H entrapped in albumin microspheres localized mainly in the liver, and the disappearance rate of radioactivity in microspheres from the tissue was very slow in comparison with that of free drugs. The microsphere might be delivered into reticuloendothelial system in the liver because ofits phagocytic activity, as well as the distribution following injection of albumin macroaggregates. Such preferential localization and sustained release of entrapped drugs suggested that albumin microspheres are useful as drug-carrier in chemotherapy.
Theoretical motions of hydrofoil systems (1947)

Report presenting an investigation to develop theoretical methods of treating the motions of hydrofoil systems and to determine some important parameters. Variations in the parameters include three distributions of area between the hydrofoils, two rates of change of downwash angle with angle of attack, three depths of immersion, two dihedral angles, two rates of change of lift with immersion, three longitudinal hydrofoil spacings, two radii of gyration in pitching, and various horizontal and vertical locations of the center of gravity.
A proposed new structure for SEU immunity in SRAM employing drain resistance (1987)

A novel static random access memory (SRAM) cell is proposed (LRAM) in which resistors are used to delay ion-induced transients conventionally, and to divide down voltage transients at the information node. The voltage divider is a new concept in SEU hardening and has practical value for technologies where the voltage transient duration is significantly different for responses to ion strikes at p- and n-channel drains. In combination, the two pairs of resistors allow much reduced resistor values with the advantage of faster access times, better temperature stability, and better scalability. Advanced simulations in which transport and circuit effects are modeled simultaneously are used to project the viability of the LRAM concept and data from single-cell test structures and support the analysis.
Allosteric regulatory step and configuration of the ATP-binding pocket in atrial natriuretic factor receptor guanylate cyclase transduction mechanism (2001)

The atrial natriuretic factor (ANF) signal transduction mechanism consists of the transformation of the signal information into the production of cyclic GMP. The binding of ANF to its receptor, which is also a guanylate cyclase, generates the signal. This cyclase has been termed atrial natriuretic factor receptor guanylate cyclase, ANF-RGC. ANF-RGC is a single transmembrane-spanning protein. The ANF receptor domain resides in the extracellular region of the protein, and the catalytic domain is located in the intracellular region at the C-terminus of the protein. Thus, the signal is relayed progressively from the receptor domain to the catalytic domain, where it is converted into the formation of cyclic GMP. The first transduction step is the direct binding of ATP with ANF-RGC. This causes allosteric regulation of the enzyme and primes it for the activation of its catalytic moiety. The partial structural motif of the ATP binding domain in ANF-RGC has been elucidated, and it has been named ATP regulatory module (ARM). In this presentation, we provide a brief review of the ATP-regulated transduction mechanism and the ARM model. The model depicts a configuration of the ATP-binding pocket that has been experimentally validated, and the model shows that the ATP-dependent transduction process is a two- (or more) step event. The first step involves the binding of ATP with its ARM. This partially activates the cyclase and prepares it for the subsequent steps, which are consistent with its being phosphorylated and attaining the fully activated state.Key words: ANF, ANF-receptor guanylate cyclase (ANF-RGC), ATP, ATP-regulatory module (ARM).
Abstracts and Reviews (1966)

Abstract Eric Berne, M.D.: Games People Play. Grove Press, New York, 1964. 192 pages. Price $5.00. Reviewed by Hugo G. Beigel Finkle, Alex M., Ph.D., M.D. and Prian, Dimitry F. Sexual Potency in Elderly Men before and after Prostatectomy. J.A.M.A., 196: 2, April, 1966. Reviewed by H. George Liebman Calvin C. Hernton: Sex and Racism In America. Grove Press, Inc. Black Cat Edition No. 113 (Paperback), 1966, 180 pp. Price $.95. Reviewed by Gus Woltmann Hans Lehfeldt, M.D., Ernest W. Kulka, M.D., H. George Liebman, M.D.: Comparative Study of Uterine Contraceptive Devices. Obstetrics and Gynecology, 26: 5, 1965, pp. 679–688. Lawrence Lipton. The Erotic Revolution. Sherbourne Press, Los Angeles, 1965. 322 pp., Price $7.50. Masters, William H., M.D. and Johnson, Virginia E. Human Sexual Response. Boston: Little, Brown and Co., 1966. 366 pages. Price $.10.00. Reviewed by Hans Lehfeldt Douglas P. Murphy, M.D. and Editha F. Torrano, M.D. Male Fertility in 3620 Childless Couples. Fertility and Sterility, 16: 3, May–June, 1965. Reviewed by Leo Wollman, M.D. Edwin M. Schur, Editor: The Family and the Sexual Revolution, Indiana University Press, Bloomington, Indiana, 1964. 427 pgs. Weldon, Virginia F., M.D., Blizzard, Robert M., M.D., and Migeon, Claude, M.D. Newborn Girls Misdiagnosed as Bilaterally Chryptorchid Males. The New England Journal of Medicine, April 14, 1966. Reviewed by H. George Liebman
High-Risk Human Papillomavirus Affects Prognosis in Patients With Surgically Treated Oropharyngeal Squamous Cell Carcinoma (2006)

Our molecular and clinical results are in agreement with previous findings but provide additional information into the biologic mechanisms involved in HR-HPV oropharyngeal cancer in comparison to HPV-negative tumors. According to the reduced risk of relapse and second tumors associated with HR-HPV positivity of oropharyngeal cancer, the therapeutic strategy and follow-up procedures should be reviewed.
Immunoscintigraphic evaluation of lymph node involvement in prostatic carcinoma (1987)

Five patients who were candidates for radical prostatectomy were investigated. One milligram of diethylene triamine pentaacetic acid derivatives of purified F(ab')2 fragments of monoclonal antibodies against prostatic acid phosphatase, labeled with 99mTc, were bilaterally injected into the periprostatic space. The amount of radioactivity injected varied between 3 and 7 mCi. Imaging took place dynamically for the first hour following injection, then at 6 and 24 hr. In one patient, lymph node metastases were detected in the left paraaortic, iliac, and obturator lymph nodes by this technique. The lesions incorporating radioactivity were confirmed to be metastases of prostatic cancer following staging pelvic lymphadenectomy. Immunolabeling electron microscopy studies revealed internalized antibody in prostatic cancer cells. In the four other patients, radioimaging did not show any lymph node metastases, and this negative finding was confirmed at surgery. These early data indicate the possibility of preoperative staging of prostatic cancer using radiolabeled derivatives of monoclonal antibodies raised against prostatic acid phosphatase and injected into the periprostatic area.
Immersive FPS games (2013)

Computer games are ideally placed to form the content of future Immersive Media, but this prospect is faced with both technical and usability issues. This paper describes an experiment in immersive gaming using a state-of-the-art computer First Person Shooter (FPS) game, in which we analyze user experience and performance through a combination of in-game metrics, questionnaires and subjective reports. We describe the evaluation of a major commercial computer game as a real-time immersive stereoscopic experience based on a four-screen CAVE-like installation. The implementation is based on a bespoke VR middleware developed on top of the game's own engine. Our results show an overwhelming subjective preference for the immersive version despite a decrease in performance attributed to a more realistic aiming mechanism. More importantly, metrics suggest that users took advantage of the immersive context rather than simply transposing their desktop gaming skills.
Novel Gate-Protection Devices for MOSFET's (1982)

Novel gate-protection devices for vertical-type power MOSFET's are developed utilizing a poly-Si film on an insulator. It is shown experimentally that, a breakdown voltage higher than 20 V, a leakage current of about 0.1 A/cm2, and a destructive breaking strength more than 300 V satisfy specifications for gate-protection devices. Power MOSFET's with the gate-protection device show remarkably reduced gate short characteristics against a simulated static discharge. These latch-up free, gate-protection devices should prove very useful for every type of MOS device.
Point-Source Corona Current Distribution in an External Field (1978)

A simple expression is derived that describes the spreading of the current stream stemming from a point corona electrode situated in a uniform external field. The analysis assumes a uniform current density in the stream, constant mobility, and constant longitudinal field, and solves the equations of continuity and Poisson. Formula accuracy is determined to be about 10 percent by comparison with current density scans taken with a boundary probe.
Nanocrystalline materials (1995)

The current status of research and development on the structure and properties of nanocrystalline materials is reviewed. Nanocrystalline materials are polycrystalline materials with grain sizes of up to about 100 nm. Because of the extremely small dimensions, a large volume fraction of the atoms is located at the grain boundaries, and this confers special attributes to these materials.Nanocrystalline materials can be prepared by inert gas condensation, mechanical alloying, plasma deposition, spray conversion processing, and many other methods. These are briefly reviewed. A clear picture of the structure of nanocrystalline materials is only now emerging. Whereas the earlier workers had concluded that the structure of grain boundaries in nanocrystalline materials was quite different from that in coarse grained materials, recent studies have shown unambiguously that the structure of the grain boundaries is the same in both nanocrystalline and coarse grained materials.The properties of nanocrystalline materials are very often superior to those of conventional polycrystalline coarse grained materials. Nanocrystalline materials exhibit increased strength/hardness, enhanced diffusivity, improved ductility/toughness, reduced density, reduced elastic modulus, higher electrical resistivity, increased specific heat, higher thermal expansion coefficient, lower thermal conductivity, and superior soft magnetic properties in comparison with conventional coarse grained materials. New concepts of nanocomposites and nanoglasses are also being investigated with special emphasis on ceramic composites to increase their strength and toughness. There appears to be a great potential for applications in the near future for nanocrystalline materials. The extensive investigations in recent years on structure-property correlations in nanocrystalline materials have begun to unravel the complexities of these materials, and pave the way for successful exploitation of alloy design principles to synthesise better materials than hitherto available.
Regulation of Type IV Secretion Apparatus Genes during <i>Ehrlichia chaffeensis</i> Intracellular Development by a Previously Unidentified Protein (2008)

The type IV secretion (T4S) system is critical for the virulence of several pathogens. In the rickettsial pathogen Ehrlichia chaffeensis, the virBD genes are split into two operons, the virB3-virB6 (preceded by sodB) and virB8-virD4 operons. Between these two operons, there are duplications of virB4, virB8, and virB9. In this study we found that transcription of all five loci was downregulated prior to the release of E. chaffeensis from host THP-1 cells and was upregulated at the initiation of exponential growth. Electrophoretic mobility shift assays revealed an E. chaffeensis-encoded protein that specifically bound to the promoter regions upstream of the virBD loci. The protein was purified from the bacterial lysate by affinity chromatography using a biotinylated promoter region upstream of sodB. Mass spectrometry identified the protein as an E. chaffeensis 12.3-kDa hypothetical protein, which was designated EcxR. Recombinant EcxR bound to the promoter regions upstream of five individual virBD loci. EcxR also activated transcription of all five virBD loci in lacZ reporter constructs. The expression of ecxR was positively autoregulated by EcxR. These results suggest that the five virBD loci are coordinately regulated by EcxR to allow developmental stage-specific expression of the T4S system in E. chaffeensis.
Prospective Study Comparing Wounds Closed With Tape With Sutured Wounds in Colorectal Surgery (2001)

Compared with the traditional suture method, paper tape closure in the treatment of clean-contaminated wounds was less time consuming and produced greater patient satisfaction with no increased rate of wound complications.
A CONVENIENT SYNTHESIS OF FUSED 4-MERCAPTOPYRIMIDINES FROM o-AMINONITRILES (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA CONVENIENT SYNTHESIS OF FUSED 4-MERCAPTOPYRIMIDINES FROM o-AMINONITRILESEdward C. Taylor and John A. ZoltewiczCite this: J. Am. Chem. Soc. 1961, 83, 1, 248–249Publication Date (Print):January 1, 1961Publication History Published online1 May 2002Published inissue 1 January 1961https://pubs.acs.org/doi/10.1021/ja01462a050https://doi.org/10.1021/ja01462a050research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and lyotropic liquid crystal properties of chiral helical polycarbodiimides (2004)

Chiral helical polymers have been expected to exhibit optical activity with a significantly large optical rotation power. In this paper polymethylphenylethylcarbodiimides (Poly-PhEMCDI) with helical structure were synthesized by the insertion polymerization of a corresponding chiral monomeric carbodiimide initiated by a copper complex. The circular dichroism spectra and optical rotation power induced by the ordered rigid main chain helical structure of polycarbodiimides, in solution and as cast films, were studied. Polycarbodiimides have a rigid rod helical structure and form lyotropic liquid crystal (LLC) in organic solvents such as dichloromethane (DCM), chloroform and THF. The LLC phase was studied using polarizing optical microscopy and X-ray diffraction. A chiral nematic phase was formed in DCM and chloroform in the concentration range 20–36%. Spherulites were formed in more concentrated solution. The formation of a LLC phase in polycarbodiimides organic solutions makes it possible to align the polymer helical chain to form an ordered film for electro-optical applications.
Shadow spectral fiming: a method of investigating electrothermal atomization. Part 2. Dynamics of formation and structure of the absorption layer of aluminium, indium and gallium molecules (1992)

The shadow spectral filming method suggested in Part 1 of this paper is used to study the dynamics of formation and structure of the absorption layers of Ga, In and Al molecules. The molecules of these elements are confined to the central part of the graphite atomizer and their distribution is strongly non-homogeneous with a pronounced decrease in concentration near the graphite walls. The cross-sectional distribution of these molecules, along with other experimental evidence, suggests that the molecular species recorded were Ga2O, In2O and Al2O. During the atomization of In, Ga and especially Al, these suboxides and their heterogeneous reactions with the graphite surface play an important role. The process of vaporization of aluminium-containing salts consists of two pronounced stages. Firstly, the sample is vaporized as a gaseous suboxide and secondly, the suboxide is oxidized to form finely dispersed, condensed alumina, Al2O3(s,l). The cloud of condensed alumina has a ‘doughnut’ structure that mimics the inner surface of the graphite tube.
Oligonudeotides complementary to a promoter over the region −8… + 2 as transcription primers for<i>E. coli</i>RNA polymerase (1984)

Primer-dependent transcription by E. coli RNA polymerase on T7 promoter A2 has been studied. Synthetic deoxyribonucleotides complementary to the promoter over the region -8...+2 were taken as primers. A ribonucleoside residue was present at the 3'-end of some of these oligonucleotides. The octanucleotide complementary to the region -8...-1 appeared to be an active primer. Oligonucleotides having lengths from 3 to 6 nucleotide residues complementary to the promoter over the region -4...+2 also exhibited primer activity. The latter was some 5-10 times greater in the case of oligonucleotides having a ribonucleoside residue at the 3'-end. Oligonucleotides which on complementary binding do not reach the center of phosphodiester bond synthesis, as well as the decanucleotides (-8...+2) and octanucleotides (-6...+2) of both the ribo- and deoxyribo-series were inactive as primers.
<i>Chx10</i>repression of<i>Mitf</i>is required for the maintenance of mammalian neuroretinal identity (2004)

During vertebrate eye development, the cells of the optic vesicle (OV) become either neuroretinal progenitors expressing the transcription factor Chx10, or retinal pigment epithelium (RPE) progenitors expressing the transcription factor Mitf. Chx10 mutations lead to microphthalmia and impaired neuroretinal proliferation. Mitf mutants have a dorsal RPE-to-neuroretinal phenotypic transformation, indicating that Mitf is a determinant of RPE identity. We report here that Mitf is expressed ectopically in the Chx10(or-J/or-J) neuroretina (NR), demonstrating that Chx10 normally represses the neuroretinal expression of Mitf. The ectopic expression of Mitf in the Chx10(or-J/or-J) NR deflects it towards an RPE-like identity; this phenotype results not from a failure of neuroretinal specification, but from a partial loss of neuroretinal maintenance. Using Chx10 and Mitf transgenic and mutant mice, we have identified an antagonistic interaction between Chx10 and Mitf in regulating retinal cell identity. FGF (fibroblast growth factor) exposure in a developing OV has also been shown to repress Mitf expression. We demonstrate that the repression of Mitf by FGF is Chx10 dependent, indicating that FGF, Chx10 and Mitf are components of a pathway that determines and maintains the identity of the NR.