gebhart/patrepeval huggingface dataset:
Metal-coordination interactions in the template-mediated synthesis of substrate-selective polymers: recognition of bis(imidazole) substrates by copper(II) iminodiacetate containing polymers (1992)

Metal-complexing polymer matrices capable of specific recognition and binding to metal-coordinating substrates have been prepared by template-directed polymerization. The synthesis of these materials involves preorganization of a copper-containing vinyl monomer, copper(II) [N-(4-vinylbenzyl)-imino]diacetic acid (1), with bifunctional bis(imidazole) templates (2-5) of varying geometry and subsequent polymerization with a large excess of ethylene glycol dimethacrylate as the cross-linking agent. Complexation of metal-chelating monomers with the template during polymerization directs the positioning of metal ions in the polymer matrices, while a high degree of cross-linking stabilizes the functional group arrangement. In equilibrium binding experiments with single substrates and selected substrate pairs, the polymers preferentially bind their own templates, with separation factors (α) of 1.17-1.35 and binding constants that range from 1800 to 3800 M^(-1). The capacities and affinities of the polymers for different substrates and ESR spectral analyses of the polymers loaded with substrate suggest a defined arrangement of metal ion sites in the templated materials that is absent in nontemplated polymers. The substrate selectivity likely involves some cooperative two-site coordination of the bis(imidazoles) as well as steric interactions with the binding cavities ("cavity fitting"). This template polymerization strategy is discussed from the viewpoint of designing highly specific abiotic receptors for recognition of delicate and complex biomolecules.
ALVAC-SIV-<i>gag</i>-<i>pol</i>-<i>env</i>-Based Vaccination and Macaque Major Histocompatibility Complex Class I (A*01) Delay Simian Immunodeficiency Virus SIV<sub>mac</sub>-Induced Immunodeficiency (2002)

T-cell-mediated immune effector mechanisms play an important role in the containment of human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) replication after infection. Both vaccination- and infection-induced T-cell responses are dependent on the host major histocompatibility complex classes I and II (MHC-I and MHC-II) antigens. Here we report that both inherent, host-dependent immune responses to SIVmac251 infection and vaccination-induced immune responses to viral antigens were able to reduce virus replication and/or CD4+ T-cell loss. Both the presence of the MHC-I Mamu-A*01 genotype and vaccination of rhesus macaques with ALVAC-SIV-gag-pol-env (ALVAC-SIV-gpe) contributed to the restriction of SIVmac251 replication during primary infection, preservation of CD4+ T cells, and delayed disease progression following intrarectal challenge exposure of the animals to SIV(mac251 (561)). ALVAC-SIV-gpe immunization induced cytotoxic T-lymphocyte (CTL) responses cumulatively in 67% of the immunized animals. Following viral challenge, a significant secondary virus-specific CD8+ T-cell response was observed in the vaccinated macaques. In the same immunized macaques, a decrease in virus load during primary infection (P = 0.0078) and protection from CD4 loss during both acute and chronic phases of infection (P = 0.0099 and P = 0.03, respectively) were observed. A trend for enhanced survival of the vaccinated macaques was also observed. Neither boosting the ALVAC-SIV-gpe with gp120 immunizations nor administering the vaccine by the combination of mucosal and systemic immunization routes increased significantly the protective effect of the ALVAC-SIV-gpe vaccine. While assessing the role of MHC-I Mamu-A*01 alone in the restriction of viremia following challenge of nonvaccinated animals with other SIV isolates, we observed that the virus load was not significantly lower in Mamu-A*01-positive macaques following intravenous challenge with either SIV(mac251 (561)) or SIV(SME660). However, a significant delay in CD4+ T-cell loss was observed in Mamu-A*01-positive macaques in each group. Of interest, in the case of intravenous or intrarectal challenge with the chimeric SIV/HIV strains SHIV(89.6P) or SHIV(KU2), respectively, MHC-I Mamu-A*01-positive macaques did not significantly restrict primary viremia. The finding of the protective effect of the Mamu-A*01 molecule parallels the protective effect of the B*5701 HLA allele in HIV-1-infected humans and needs to be accounted for in the evaluation of vaccine efficacy against SIV challenge models.
A microfluidic device enabling high-efficiency single cell trapping (2015)

Single cell trapping increasingly serves as a key manipulation technique in single cell analysis for many cutting-edge cell studies. Due to their inherent advantages, microfluidic devices have been widely used to enable single cell immobilization. To further improve the single cell trapping efficiency, this paper reports on a passive hydrodynamic microfluidic device based on the "least flow resistance path" principle with geometry optimized in line with corresponding cell types. Different from serpentine structure, the core trapping structure of the micro-device consists of a series of concatenated T and inverse T junction pairs which function as bypassing channels and trapping constrictions. This new device enhances the single cell trapping efficiency from three aspects: (1) there is no need to deploy very long or complicated channels to adjust flow resistance, thus saving space for each trapping unit; (2) the trapping works in a "deterministic" manner, thus saving a great deal of cell samples; and (3) the compact configuration allows shorter flowing path of cells in multiple channels, thus increasing the speed and throughput of cell trapping. The mathematical model of the design was proposed and optimization of associated key geometric parameters was conducted based on computational fluid dynamics (CFD) simulation. As a proof demonstration, two types of PDMS microfluidic devices were fabricated to trap HeLa and HEK-293T cells with relatively significant differences in cell sizes. Experimental results showed 100% cell trapping and 90% single cell trapping over 4 × 100 trap sites for these two cell types, respectively. The space saving is estimated to be 2-fold and the cell trapping speed enhancement to be 3-fold compared to previously reported devices. This device can be used for trapping various types of cells and expanded to trap cells in the order of tens of thousands on 1-cm(2) scale area, as a promising tool to pattern large-scale single cells on specific substrates and facilitate on-chip cellular assay at the single cell level.
An ethylene glycol derivative of boehmite (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn ethylene glycol derivative of boehmiteMasashi Inoue, Yasuhiko Kondo, and Tomoyuki InuiCite this: Inorg. Chem. 1988, 27, 2, 215–221Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ic00275a001https://doi.org/10.1021/ic00275a001research-articleACS PublicationsRequest reuse permissionsArticle Views481Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spatially resolved gain measurements in UV preionized homogenous discharge XeCl and KrF lasers (1981)

Spatially uniform avalanche discharges of relatively long duration have been obtained in a UV-preionized, high-pressure, rare-gas–halide laser. In the case of XeCl pulse durations as long as 70 ns have been observed. The spatial distribution of the small-signal gain in a plane transverse to the laser axis has been measured. The active discharge cross sections with better than 90% gain uniformity were 2.8×3.0 and 2.8×2.5 cm2 for XeCl and KrF, respectively. The use of neon rather than helium as a buffer gas increased the discharge cross section, and the laser pulse duration resulting in improved laser output energy densities of 4.5 J/l in XeCl and 2.8 J/l in KrF.
Activity of artichoke leaf extract on reactive oxygen species in human leukocytes (2000)

Artichoke leaf extract was studied in human leukocytes for activity against oxidative stress using flow cytometry and dichlorofluorescin diacetate as a fluorescence probe. It produces a concentration-dependent inhibition of oxidative stress when cells are stimulated with agents that generate reactive oxygen species (ROS): hydrogen peroxide, phorbol-12-myristate-13-acetate (PMA), and N-formyl-methionyl-leucyl-phenylalanine (FMLP). Cynarin, caffeic acid, chlorogenic acid, and luteolin, constituents of artichoke leaf extract, also show a concentration-dependent inhibitory activity in the above models, contributing to the antioxidant activity of the extract in human neutrophils.
Pyrogenic carbon capture and storage (2018)

Abstract The growth of biomass is considered the most efficient method currently available to extract carbon dioxide from the atmosphere. However, biomass carbon is easily degraded by microorganisms releasing it in the form of greenhouse gases back to the atmosphere. If biomass is pyrolyzed, the organic carbon is converted into solid (biochar), liquid (bio‐oil), and gaseous (permanent pyrogas) carbonaceous products. During the last decade, biochar has been discussed as a promising option to improve soil fertility and sequester carbon, although the carbon efficiency of the thermal conversion of biomass into biochar is in the range of 30%–50% only. So far, the liquid and gaseous pyrolysis products were mainly considered for combustion, though they can equally be processed into recalcitrant forms suitable for carbon sequestration. In this review, we show that pyrolytic carbon capture and storage (PyCCS) can aspire for carbon sequestration efficiencies of >70%, which is shown to be an important threshold to allow PyCCS to become a relevant negative emission technology. Prolonged residence times of pyrogenic carbon can be generated (a) within the terrestrial biosphere including the agricultural use of biochar; (b) within advanced bio‐based materials as long as they are not oxidized (biochar, bio‐oil); and (c) within suitable geological deposits (bio‐oil and CO 2 from permanent pyrogas oxidation). While pathway (c) would need major carbon taxes or similar governmental incentives to become a realistic option, pathways (a) and (b) create added economic value and could at least partly be implemented without other financial incentives. Pyrolysis technology is already well established, biochar sequestration and bio‐oil sequestration in soils, respectively biomaterials, do not present ecological hazards, and global scale‐up appears feasible within a time frame of 10–30 years. Thus, PyCCS could evolve into a decisive tool for global carbon governance, serving climate change mitigation and the sustainable development goals simultaneously.
Alkylation of Xylenes with Ethylene and Propylene (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkylation of Xylenes with Ethylene and PropyleneE. V. KIRKLAND, O. P. FUNDERBURK, and F. T. WADSWORTHCite this: J. Org. Chem. 1958, 23, 11, 1631–1635Publication Date (Print):November 1, 1958Publication History Published online1 May 2002Published inissue 1 November 1958https://pubs.acs.org/doi/10.1021/jo01105a013https://doi.org/10.1021/jo01105a013research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Moment-Based Quantile Sketches for Efficient High Cardinality Aggregation Queries (2018)

Interactive analytics increasingly involves querying for quantiles over sub-populations of high cardinality datasets. Data processing engines such as Druid and Spark use mergeable summaries to estimate quantiles, but summary merge times can be a bottleneck during aggregation. We show how a compact and efficiently mergeable quantile sketch can support aggregation workloads. This data structure, which we refer to as the moments sketch, operates with a small memory footprint (200 bytes) and computationally efficient (50ns) merges by tracking only a set of summary statistics, notably the sample moments. We demonstrate how we can efficiently and practically estimate quantiles using the method of moments and the maximum entropy principle, and show how the use of a cascade further improves query time for threshold predicates. Empirical evaluation on real-world datasets shows that the moments sketch can achieve less than 1 percent error with 15 times less merge overhead than comparable summaries, improving end query time in the MacroBase engine by up to 7 times and the Druid engine by up to 60 times.
Intensification of volatile organic compound absorption in a compact wet scrubber at co-current flow (2017)

Three volatile organic compounds (VOC) with no acidic or basic function (butanol, butyraldehyde, methylethylketone), encountered at low concentrations in odorous effluents, were absorbed in water in a compact wet scrubber. This gas-liquid contactor consisted of a wire mesh packing structure where the gas phase flows at high velocity (>12 m s<sup>-1</sup>). A very turbulent two-phase downward flow could be observed in the scrubber with dispersed fine droplets (around 10 μm). For compounds showing a good affinity for water, such as butanol, removal efficiencies up to 90% were measured for a short contactor length of 32 cm leading to a gas residence time of 20 ms. However, the removal efficiency of butyraldehyde, which is poorly soluble in water, ranged between 10 and 30%. Mass-transfer modeling was achieved and underlined that working with several small scrubbers in series, fed with an unloaded solution, is effective to improve the removal efficiency. The influences of the VOC/solvent affinity, the contactor length, and the mass-transfer and hydrodynamic parameters on the removal efficiency were evaluated through a sensitivity analysis.
Viewing zones in three-dimensional imaging systems based on lenticular, parallax-barrier, and microlens-array plates (2004)

The viewing zone of autostereoscopic imaging systems that use lenticular, parallax-barrier, and microlens-array plates as the viewing-zone-forming optics is analyzed in order to verify the image-quality differences between different locations of the zone. The viewing zone consists of many subzones. The images seen at most of these subzones are composed of at least one image strip selected from the total number of different view images displayed. These different view images are not mixed but patched to form a complete image. This image patching deteriorates the quality of the image seen at different subzones. We attempt to quantify the quality of the image seen at these viewing subzones by taking the inverse of the number of different view images patched together at different subzones. Although the combined viewing zone can be extended to almost all of the front space of the imaging system, in reality it is limited mainly by the image quality.
Novel structures of carbon layers on a Pt(111) surface (2005)

Abstract The growth behaviour of carbon layers formed on a Pt(111) surface has been investigated by means of scanning tunnelling microscopy. A carbon layer with a ( $\sqrt{19}$ × $\sqrt{19}$ )R23.4° structure was grown by benzene exposure of 3 L at 1000 K. After exposure of >10 L, graphene islands with hexagonal shapes appeared in the surface terraces. The graphene islands grew beyond step edges, and their growth often caused bunching of the step edges by Pt atom migration. Copyright © 2005 John Wiley & Sons, Ltd.
A review of the efficacy and safety of eslicarbazepine acetate in the management of partial-onset seizures (2015)

Eslicarbazepine acetate is a is a once-daily antiepileptic drug (AED) that was approved in 2009 by the European Medicines Agency (EMA) (Zebinix™), and in 2013 by the US Food and Drug Administration (FDA) (Aptiom™) as adjunctive therapy in adults with refractory partial-onset seizures, with or without secondary generalization. It is a third-generation member of the dibenzazepine family of AEDs with distinctive mechanism of action, posology and tolerability profile. The eslicarbazepine acetate development program included an initial phase II study (study BIA 2-093) and three subsequent phase III, multicentre, randomized, double-blinded and placebo-controlled clinical trials (studies BIA-2093-301, BIA- 2093-302 and BIA -2093-303). A fourth phase III placebo-controlled trial (study BIA-2093-304) was designed in order to meet specific requirements of the FDA. All performed studies have consistently shown that eslicarbazepine acetate (800 to 1200 mg/day) is effective and well tolerated as adjunctive therapy for adults with partial-onset seizures.
Mechanism and Kinetics for the Formation of Uranium Mononitride by the Reaction of Uranium Dioxide with Carbon and Nitrogen (1978)

The mechanism and kinetics of UN formation by reaction of a pellet of mixed UO 2 and C with N 2 were studied for temperatures of 1420° to 1750°C. The reaction followed the first‐order rate equation; the activation energy was 83 kcal/mol. Only UN 1−x C x was produced. The lattice parameter variation of UN 1−x C x had a minimum and a maximum during reaction; at the maximum, UN 1−x C x + C + N 2 were in equilibrium. The overall reaction was divided into four stages: (1) formation of UN 1−x C x from UO 2 , (2) decarburization of UN 1−x C x , (3) formation of UN 1−x C x with the equilibrium composition, and (4) pure UN formation. The lowest reaction rate was in stage (4).
Capacity bounds for two-dimensional asymmetric M-ary (0, κ) and (d,α) runlength-limited channels (2009)

We present bounds on the two-dimensional capacity for two sets of symmetric and asymmetric M-ary runlength-limited constraints based on simple constructions. The bounds extend and generalize previous work on binary constraints.
A completely intramedullary leg lengthening device [using SMA actuator] (2002)

The procedure and the external fixator for lengthening long bones was developed by G.A. Ilizarov in the late 1960's. This technique has, despite its proven abilities for leg lengthening and correction of angular deformities, some considerable disadvantages for patients. Discomfort, infections and restricted weight bearing are some reasons for the development of a completely intramedullary device for leg lengthening. The device developed is a telescopic intramedullary nail with a maximum diameter of 13 mm, which can be lengthened with 0.5 mm steps induced by a shape memory alloy actuator. The electrical energy for the actuator is supplied from outside the body by inductive coupling of two solenoid coils. Internally, the electrical energy is transformed to thermal energy by thermofoils and Peltier-elements.
Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's‐diseased striatum (1991)

The cocaine congener [3H]CFT, also designated [3H]WIN 35,428 (2 beta-carbomethoxy-3 beta-(4-fluorophenyltropane), labels cocaine receptors associated with the dopamine transporter in primate striatum. Autoradiographic distribution of [3H]CFT binding (5 nM) in human postmortem control and Parkinson's-diseased striatal tissue sections was compared. In control tissue, high and comparable levels of [3H]CFT binding were observed in the putamen and caudate nucleus. At least 90-99% of total [3H]CFT bound was inhibited by (-)-cocaine (30 microM), suggesting that a high proportion of [3H]CFT is specifically bound. In Parkinson's-diseased tissue, binding sites for [3H]CFT were reduced by 80% in the caudate nucleus and 96% in the putamen. This pattern of depletion parallels the previously reported loss of dopamine in these brain regions (Kish, Shannak, and Hornykiewicz, New Engl. J. Med., 318:876-880, 1988). In the dorsal caudate nucleus of Parkinson's-diseased tissue, a lateral-to-medial gradient of [3H]CFT binding was observed, with the lateral caudate more severely depleted than the medial caudate. The marked decrease of [3H]CFT binding sites in Parkinson's diseased striatum supports the following conclusions: 1) the dopamine transporter is localized primarily on presynaptic nigrostriatal terminals; 2) in the caudate and putamen, cocaine recognition sites are associated primarily with the dopamine transporter; 3) the low level of nonspecific binding of [3H]CFT and the marked depletion of [3H]CFT-labeled sites suggest that radiolabeled derivatives of CFT or its congeners may be suitable imaging probes for presynaptic dopamine nerve terminals.
A Practical Solution for Dyspareunia in Breast Cancer Survivors: A Randomized Controlled Trial (2015)

Breast cancer survivors with menopausal dyspareunia can have comfortable intercourse after applying liquid lidocaine compresses to the vulvar vestibule before penetration.
Feature-based locomotion controllers (2010)

This paper introduces an approach to control of physics-based characters based on high-level features of movement, such as center-of-mass, angular momentum, and end-effectors. Objective terms are used to control each feature, and are combined by a prioritization algorithm. We show how locomotion can be expressed in terms of a small number of features that control balance and end-effectors. This approach is used to build controllers for human balancing, standing jump, and walking. These controllers provide numerous benefits: human-like qualities such as arm-swing, heel-off, and hip-shoulder counter-rotation emerge automatically during walking; controllers are robust to changes in body parameters; control parameters and goals may be modified at run-time; control parameters apply to intuitive properties such as center-of-mass height; and controllers may be mapped onto entirely new bipeds with different topology and mass distribution, without modifications to the controller itself. No motion capture or off-line optimization process is used.