gebhart/patrepeval huggingface dataset:
WakeScope: Runtime WakeLock anomaly management scheme for Android platform (2013)

Android provides a WakeLock mechanism for application developers to ensure the proper execution of applications without having to enter the sleep state of a device. When using the WakeLock mechanism, application developers should bear the responsibility of adequately releasing the acquired lock. Otherwise, the energy will unnecessarily be wasted due to a locked application. This paper presents a scheme, called WakeScope, to handle WakeLock misuse. The scheme is designed to detect and notify of a misuse case of WakeLock handling, which may arise with an application and even with an Android runtime system, and thus provides a practical tool to prevent energy waste in mobile devices. Our experiments with real applications show that WakeScope accurately detects the misused case, with runtime overhead of approximately 1.2% in CPU usage.
Revealing the retail black box by interaction sensing (2004)

Today a huge variety of methods to track and analyze the customers' behavior in e-commerce systems is available. However, in traditional retail stores such systems are not widely known and therefore the customers' behavior is considered as a black box in this domain. This paper presents the Smart Shelf technology able to track basic simple actions, such as take, return and remove, which are performed on items by the customer. These actions form the interaction context replacing the black box. We will show that this context can be used to enhance existing data mining and store management systems as well as the customer will benefit from recommendation systems comparable to those used in e-commerce systems of online stores.
KIF2 is a new microtubule-based anterograde motor that transports membranous organelles distinct from those carried by kinesin heavy chain or KIF3A/B. (1995)

Kinesin is known as a representative cytoskeletal motor protein that is engaged in cell division and axonal transport. In addition to the mutant assay, recent advances using the PCR cloning technique have elucidated the existence of many kinds of kinesin-related proteins in yeast, Drosophila, and mice. We previously cloned five different members of kinesin superfamily proteins (KIFs) in mouse brain (Aizawa, H., Y. Sekine, R. Takemura, Z. Zhang, M. Nangaku, and N. Hirokawa. 1992. J. Cell Biol. 119:1287-1296) and demonstrated that one of them, KIF3A, is an anterograde motor (Kondo, S., R. Sato-Yashitake, Y. Noda, H. Aizawa, T. Nakata, Y. Matsuura, and N. Hirokawa. J. Cell Biol. 1994. 125:1095-1107). We have now characterized another axonal transport motor, KIF2. Different from other KIFs, KIF2 is a central type motor, since its motor domain is located in the center of the molecule. Recombinant KIF2 exists as a dimer with a bigger head and plus-end directionally moves microtubules at a velocity of 0.47 +/- 0.11 microns/s, which is two thirds that of kinesin's. Immunocytological examination showed that native KIF2 is abundant in developing axons and that it accumulates in the proximal region of the ligated nerves after a 20-h ligation. Soluble KIF2 exists without a light chain, and KIF2's associated-vesicles, immunoprecipitated by anti-KIF2 antibody, are different from those carried by existing motors such as kinesin and KIF3A. They are also distinct from synaptic vesicles, although KIF2 is accumulated in so-called synaptic vesicle fractions and embryonal growth cone particles. Our results strongly suggest that KIF2 functions as a new anterograde motor, being specialized for a particular group of membranous organelles involved in fast axonal transport.
An optimization design method for control law of Lateral Navigation (2013)

In order to maintain Air Traffic Control (ATC) system safety and efficiency, the Flight Management System (FMS), as a complete system, must provides for automated Vertical and Lateral Navigation (LNAV). In which, LNAV is the major issue for air traffic controllers. For the problem of designing control law of LNAV in FMS, an optimal design method is proposed. Genetic Algorithm (GA) is used in optimizing the gain of roll angle command, cross track error (XTK) and track error (TKE) are computed as the variables of objective function. A goal of this paper is to provide a generic method and can be extended to the optimization of other LNAV and VNAV on different platforms. Numerical simulations among the optimized roll angle command gains and other gains provide by FMS manufacturers are given to illustrate the effectiveness of the proposed method.
Structural Color for Additive Manufacturing: 3D-Printed Photonic Crystals from Block Copolymers (2017)

The incorporation of structural color into 3D printed parts is reported, presenting an alternative to the need for pigments or dyes for colored parts produced through additive manufacturing. Thermoplastic build materials composed of dendritic block copolymers were designed, synthesized, and used to additively manufacture plastic parts exhibiting structural color. The reflection properties of the photonic crystals arise from the periodic nanostructure formed through block copolymer self-assembly during polymer processing. The wavelength of reflected light could be tuned across the visible spectrum by synthetically controlling the block copolymer molecular weight and manufacture parts that reflected violet, green, or orange light with the capacity to serve as selective optical filters and light guides.
Intensity-modulated, stepped frequency cw lidar for distributed aerosol and hard target measurements (2005)

A compact frequency-modulated, continuous wave (FM-cw) lidar system for measurement of distributed aerosol plumes and hard targets is presented. The system is based on intensity modulation of a laser diode and quadrature detection of the return signals. The advantages of using laser diode amplitude modulation and quadrature detection is a large reduction in the hardware required for processing and storing return signals as well as the availability of off-the-shelf integrated electronic components from the wireless and telecommunication communities. Equations to invert the quadrature signal components and determine spatial distributions of multiple targets are derived. Spatial scattering intensities are used to extract aerosol backscatter coefficients, which can then be directly compared to microphysics aerosol models for environmental measurements. Finally, results from laboratory measurements with a monostatic FM-cw lidar system with both hard targets and aerosols are discussed.
Estrogen contributes to the onset, persistence, and malignant progression of cervical cancer in a human papillomavirus-transgenic mouse model (2005)

Cervical cancer is a leading cause of death by cancer among women worldwide. High-risk human papillomaviruses (HPVs) are the major etiological agents for cervical cancer, but other factors likely contribute to cervical cancer, because these cancers commonly arise decades after initial exposure to HPV. Estrogen is thought to be one such cofactor; however, its temporal requirements in human cervical cancer are not known. Here we evaluate the temporal requirements of estrogen in cervical carcinogenesis in a mouse model for HPV-associated cervical cancer. Tumors arising in HPV16 transgenic mice treated with estrogen for 9 months were greatly increased in their size compared with tumors developing after 6 months of estrogen treatment. HPV16 transgenic mice treated 6 months with estrogen followed by 3 months without exogenous estrogen had significantly fewer tumors and the tumors were smaller and less aggressive than those arising in mice treated the full 9 months. Importantly, cervical cancers that arose in the mice treated the first 6 of 9 months with estrogen must have regressed, based upon the reduced incidence of cancers in these mice compared with those treated for 6 months with estrogen, then immediately analyzed. We conclude that estrogen plays a critical role not only in the genesis of cervical cancer but also in its persistence and continued development in this mouse model. These findings raise the clinically relevant possibility that, if human cervical cancer has a similar dependence on estrogen for continued tumor growth, then antiestrogen therapy may be effective in the treatment of cervical cancer.
A Case-Based Reasoning Approach for Unknown Class Invoice Processing (2007)

This paper introduces an invoice analysis approach using case-based reasoning (CBR). CBR is used to analyze and interpret new invoices thanks to the previous processing experiences. Each new document is segmented into structures and interpreted thanks to a structure database. Interpreting a new document's structures relies on graph edit distance as well as on string edit distance. This paper focuses on document structure extraction as well as on document interpretation via its structures interpretation. The proposed system reaches an extraction and interpretation rate of 76.33%.
Data Matrix Code Location Based on Finder Pattern Detection and Bar Code Border Fitting (2012)

The 2‐D bar code possesses large capacity of data, strong ability for error correction, and high safety, which boosts the 2‐D bar code recognition technology being widely used and developed fast. This paper presents a novel algorithm for locating data matrix code based on finder pattern detection and bar code border fitting. The proposed method mainly involves three stages. It first extracts candidate regions that may contain a data matrix code by morphological processing and then locates the data matrix code roughly by detecting “L” finder pattern and the dashed border on the candidate regions. Finally, the lines fitted with the border points are used as the borders of data matrix code. A number of data matrix code images with complexity background are selected for evaluations. Experimental results show that the proposed algorithm exhibits better performance under complex background and other undesirable conditions.
Lipids and nutrition of the southern rock lobster, <i>Jasus edwardsii</i> , from hatch to puerulus (2002)

We examined the lipid class and fatty-acid composition of the southern rock lobster, Jasus edwardsii , phyllosoma larvae and puerulus stage to improve understanding of their nutrition in relation to aquaculture. Lipid is critical in the nutrition of larval crustaceans, including lobsters. Specimens were from Tasmanian waters, Australia, and North Island, New Zealand, waters. Analyses were by TLC-FID and capillary GC and GC-MS. Phyllosoma larvae and nektonic pueruli were low in storage lipid (triacylglycerol), and phospholipid was the major lipid class. Sterol, mainly cholesterol, was the next most abundant class. The ratio of the essential omega-3 fatty acid eicosapentaenoic acid (EPA) to the omega-6 fatty acid arachidonic acid (AA) was lower in newly hatched phyllosomas (1.2–1.3) than in other phyllosomas (stages III–XI; 2.8–6.7) and pueruli (3.8). Ratios of the omega-3 fatty acid DHA (docosahexaenoic acid) to EPA were also lower in newly hatched phyllosomas (0.5) than in laterstage phyllosomas (1.5–2.1) and pueruli (1.2). We have followed up these compositional data by successfully enriching the live diet ( Artemia ) of early phyllosomas with AA, EPA and DHA. This dietary manipulation has achieved ratios of these key polyunsaturated fatty acids similar to those of wild phyllosomas. These findings will be of significance to the future of rock-lobster aquaculture.
CXCR3 and α<sub>E</sub>β<sub>7</sub> integrin identify a subset of CD8+ mature thymocytes that share phenotypic and functional properties with CD8+ gut intraepithelial lymphocytes (2005)

The results of this study demonstrate the existence of a previously unrecognised subset of TCRalphabeta+CD8alphabeta+ SP CXCR3+CD103+ thymocytes which share phenotypic and functional features with CD8+ IELs, thus suggesting the possibility of their direct colonisation of the gut mucosa.
Bevacizumab in Hereditary Hemorrhagic Telangiectasia (2009)

To the Editor: Hereditary hemorrhagic telangiectasia (HHT) (also known as the Osler–Weber–Rendu syndrome) is an inherited vascular dysplasia whose main features are mucocutaneous telangiectasias, e...
<i>In Vitro</i> Cytotoxicity of Protocatechuic Acid to Cultured Human Cells from Oral Tissue: Involvement in Oxidative Stress (2002)

Data on the biologic activity of protocatechuic acid are contradictory; some studies have shown that it acts as an antioxidant and suppresses chemical-induced carcinogenesis and others that it induces oxidative stress and promotes tumour formation. The anticarcinogenicity of protocatechuic acid was postulated to be related, in part, to its specific suppression of neoplastic hyperproliferation. To determine whether protocatechuic acid was preferentially antiproliferative to malignant cells, non-malignant and carcinoma cells were exposed for 24 hr to protocatechuic acid (2.5 to 25 mM) and viability was assessed with the neutral red assay. The cell lines were derived from tissues of the human oral cavity, the initial site of exposure upon ingestion of dietary protocatechuic acid, and included normal GN61 gingival fibroblasts, immortalized, non-tumorigenic S-G gingival epithelial cells, and malignant HSG1 cells derived from the salivary gland, HSC-2 cells from the floor of the oral cavity, and CAL27 cells from the tongue. Selective toxicity of protocatechuic acid to malignant cells was not observed. Furthermore, using a total cellular protein determination to quantitate cell growth, no differences in comparative sensitivities of S-G epithelial cells and HSG1 carcinoma cells were noted in a 3 day continuous exposure to 2.5 to 12.5 mM protocatechuic acid and in recovery from a 24 hr exposure to 3 to 15 mM protocatechuic acid. The S-G and HSG1 cells were then used to study the effects of elevated concentrations of protocatechuic acid on oxidative stress. For both cell types, protocatechuic acid induced oxidative stress, presumably through its bioactivation by a tyrosinase pathway. A brief exposure to 25 mM protocatechuic acid lowered the levels of intracellular glutathione and potentiated Fe2+-induced lipid peroxidation of the cells. As determined with the neutral red assay, S-G and HSG1 cells exposed briefly to a non-toxic level (0.5 mM) of the glutathione depleter, 1,3-bis(2-chloroethyl)-N-nitrosourea, were hypersensitive to a subsequent challenge with 10 mM protocatechuic acid and preexposure of the S-G and HSG1 cells to a nontoxic level of protocatechuic acid (2.5 mM) enhanced their sensitivity to a subsequent exposure to tert-butyl hydroperoxide. These findings were consistent with protocatechuic acid, at high levels (> or = 10 mM), acting as an inducer of oxidative stress.
ChemInform Abstract: HETEROFUNCTIONAL CONDENSATION BETWEEN CHLORO‐ AND ALKOXYSILANES (1977)

Abstract Mit einer Reihe von Alkoholen erhält man aus Dimethylchlorsilan (I) die Dimethylalkoxysilane (IIa)‐(IId).
Expression of growth factor and receptor mRNAs in skin epithelial cells following acute cutaneous injury. (1993)

We report that acute injury induces the expression of selective growth factor and growth factor receptors in the epithelial cells of the wounded tissue. In situ hybridization analysis of skin biopsy specimens obtained after cutaneous injury in swine demonstrated the induction of the expression of transforming growth factor-alpha, its receptor, epidermal growth factor-R, acidic fibroblast growth factor, and basic fibroblast growth factor messenger RNAs in the skin epithelial cells of the wounded tissue. There was no significant expression in the epithelial cells of control, uninjured tissues. The expression levels were maximal during the period of active tissue repair (1 to 5 days after injury) and were totally suppressed upon the healing of the wounded tissues. In contrast, insulinlike growth factor-I, (IGF-I), IGF-I receptor, and IGF-II receptor messenger RNAs were expressed in the epithelial cells of both the control, uninjured tissues and in tissue specimens obtained after injury. There was no significant expression of IGF-II messenger RNA in the epithelial cells before or after injury. It seems that injury induces the coordinated expression of selective growth factor and growth factor receptor genes whose products contribute to the regulation of the complex processes involved in tissue repair and remodeling.
Promoting the Electrochemical Performances by Chemical Depositing of Gold Nanoparticles Inside Pores of 3D Nitrogen-Doped Carbon Nanocages (2017)

Carbon Nanomaterials are excellent electrode materials due to their extraordinary conductivity, prolific structures, and morphologies. Herein, a novel nanocarbon-based material (Au@NCNC) was synthesized by embedding gold nanoparticles (AuNPs) inside the pores of three-dimensional hierarchical nitrogen-doped carbon nanocages (NCNC) through an in situ chemical deposition method. The resultant Au@NCNC was employed as an electrochemical catalyst for the oxygen reduction reaction (ORR) and as an electrode material for supercapacitors. The conductivity and hydrophilicity of Au@NCNC were much more improved than those of pristine NCNC. Meanwhile, the bubble adhesive force on the Au@NCNC film was much lower underwater than that of NCNC, which provided easy accessibility to the active sites of reactants, such as hydrated O<sub>2</sub>. Therefore, the deposition of AuNPs inside pores of NCNC facilitated the transfer of electrons and diffusion of ions, promoting the electrocatalytic performance of Au@NCNC. As a result, Au@NCNC exhibited high performance toward ORR, which manifested in high numbers of electron transfer (3.7-3.9), high kinetic current density, enhanced electrocatalytic stability, and remarkable methanol durability. Moreover, Au@NCNC displayed high specific capacitance, good rate capability, and cycling stability with ∼97% of its initial capacitance retained at the high current density of 10 A g<sup>-1</sup> after 5000 cycles. This could be attributed to the synergetic effect of ultrafine gold nanoparticles, the hierarchical porous structure, and the hydrophilic surface of NCNC as well. This work offers an excellent alternative for Pt-based catalysts in fuel cells, ORR, and supercapacitive electrode materials by enhancing the conductivity and surface hydrophilicity of electrocatalysts.
Multiple Oncogenic Changes (<i>K-RASV12</i>, p53 Knockdown,<i>Mutant EGFRs, p16</i>Bypass, Telomerase) Are Not Sufficient to Confer a Full Malignant Phenotype on Human Bronchial Epithelial Cells (2006)

We evaluated the contribution of three genetic alterations (p53 knockdown, K-RAS(V12), and mutant EGFR) to lung tumorigenesis using human bronchial epithelial cells (HBEC) immortalized with telomerase and Cdk4-mediated p16 bypass. RNA interference p53 knockdown or oncogenic K-RAS(V12) resulted in enhanced anchorage-independent growth and increased saturation density of HBECs. The combination of p53 knockdown and K-RAS(V12) further enhanced the tumorigenic phenotype with increased growth in soft agar and an invasive phenotype in three-dimensional organotypic cultures but failed to cause HBECs to form tumors in nude mice. Growth of HBECs was highly dependent on epidermal growth factor (EGF) and completely inhibited by EGF receptor (EGFR) tyrosine kinase inhibitors, which induced G1 arrest. Introduction of EGFR mutations E746-A750 del and L858R progressed HBECs toward malignancy as measured by soft agar growth, including EGF-independent growth, but failed to induce tumor formation. Mutant EGFRs were associated with higher levels of phospho-Akt, phospho-signal transducers and activators of transcription 3 [but not phospho-extracellular signal-regulated kinase (ERK) 1/2], and increased expression of DUSP6/MKP-3 phosphatase (an inhibitor of phospho-ERK1/2). These results indicate that (a) the HBEC model system is a powerful new approach to assess the contribution of individual and combinations of genetic alterations to lung cancer pathogenesis; (b) a combination of four genetic alterations, including human telomerase reverse transcriptase overexpression, bypass of p16/RB and p53 pathways, and mutant K-RAS(V12) or mutant EGFR, is still not sufficient for HBECs to completely transform to cancer; and (c) EGFR tyrosine kinase inhibitors inhibit the growth of preneoplastic HBEC cells, suggesting their potential for chemoprevention.
Inter-familial relationships of the shorebirds (Aves: Charadriiformes) based on nuclear DNA sequence data (2003)

The DNA sequence data contains a strong phylogenetic signal that results in a well-resolved phylogenetic tree with many strongly supported internodes. Taxonomically it is the most inclusive study of shorebird families that relies on nucleotide sequences. The presented phylogenetic hypothesis provides a solid framework for analyses of macroevolution of ecological, morphological and behavioural adaptations observed within the order Charadriiformes.
Occurrence of multiple fluid phases across a basin, in the same shale gas formation -- Eagle Ford Shale example (2014)

Shale gas and oil are playing a significant role in US energy independence by reversing declining production trends. Successful exploration and development of the Eagle Ford Shale Play requires reservoir characterization, recognition of fluid regions, and the application of optimal operational practices in all regions.\n\nUsing stratigraphic and petrophysical analyses, we evaluated key parameters, of reservoir depth and thickness, fluid composition, reservoir pressure, total organic carbon (TOC), and number of limestone and organic-rich marl interbeds of the Lower Eagle Ford Shale. Spatial statistics were used to identify key reservoir parameters affecting Eagle Ford production. We built reservoir models of various fluid regions and history matched production data. Well deliverability was modeled to optimize oil production rate by designing appropriate operational parameters.\n\nFrom NW to SE, Eagle Ford fluids evolve from oil, to gas condensate and, finally, to dry gas, reflecting greater depth and thermal maturity. From outcrop, the Eagle Ford Shale dips southeastward; depth exceeds 13,000 ft at the Sligo Shelf Margin. We divided Eagle Ford Shale into three layers. The Lower Eagle Ford is present throughout the study area; it is more than 275 ft thick in the Maverick Basin depocenter and thins to less than 50 ft on the northeast. In the Lower Eagle Ford Shale, a strike-elongate trend of high TOC, high average gamma ray values, and low bulk density extends from Maverick Co. northeastward through Guadalupe Co. Both limestone and organic-rich marl beds increase in number from fewer than 2 near outcrop to more than 20 at the shelf margins. Average thicknesses of Lower Eagle Ford limestone and organic-rich marl beds are low (< 5 ft.) in the La Salle – DeWitt trend, coincident with the most productive gas and oil wells. Eagle Ford Shale was divided into 5 production regions in South Texas that coincide with the regional, strike-elongate trends of geologic parameters, which suggests that these parameters significantly impact Eagle Ford Shale production.\n\nEagle Ford Shale production (barrels of oil equivalent, BOE) increases consistently with depth, increases with Lower Eagle Ford thickness (up to 180-ft thickness), and increases with TOC (up to 7%). P values analyses suggest high certainty of the relationship between the production and five reservoir parameters tested in regression models.\n\nMultiple good history matches of a gas condensate well suggest significant uncertainties in reservoir parameters. Oil production rate is not sensitive to oil relative permeability for the gas condensate well model. We were unable to match the production history for the volatile oil wells, possibly because gas of lift. Reservoir modeling suggests low bottomhole flowing pressure was the key to optimize cumulative oil production.\n\nConcepts and models developed in this study may assist operators in making critical Eagle Ford Shale development decisions; they may be transferable to other shale plays.