gebhart/patrepeval huggingface dataset:
Multilayer Inorganic Electrets with <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msub><mml:mrow><mml:mtext>SiO</mml:mtext></mml:mrow><mml:mn mathvariant="bold">2</mml:mn></mml:msub></mml:mrow></mml:math> and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msub><mml:mrow><mml:mtext>Si</mml:mtext></mml:mrow><mml:mn mathvariant="bold">3</mml:mn></mml:msub><mml:msub><mml:mtext>N</mml:mtext><mml:mn mathvariant="bold">4</mml:mn></mml:msub></mml:mrow></mml:math> Layers for Applications on Heated Machinery (2012)

The physics and basic properties of electrets are discussed, namely, what happens during corona charging of dielectrics, why the surface potential and trapped charge show certain limits, where the trapped charge is stored, why and how the charge is released from traps at high temperatures. The experiments have been conducted on single-layer SiO 2 and Si 3 N 4 and on multilayer combination of these materials. A strong lateral mobility of charge trapped near the SiO 2 /Si 3 N 4 interface was observed at elevated temperatures. The positively and negatively charged electrets are compared to each other. The experiments on charge retention at elevated temperatures have shown the studied electrets are suitable for devices working at temperatures of up to 200–300 ° C.
<title>Integration of fluid-based analytical model with packet-level simulation for analysis of computer networks</title> (2001)

Fluid flow analytical models have been shown to be able to capture the dynamics of TCP flows and can scale well to solving for networks with a large number of flows. However, accurate closed form solutions are not yet available for wireless networks. Traditional packet-level discrete event simulations provide accurate predictions of network behavior, but their solution time can increase significantly with the number of flows being simulated. Integration of fluid flow models with packet-level simulators appears to offer significant benefits. In this paper, we describe an approach to integrate fluid flow models into QualNet, a scalable packet-level simulator. We validate the mixed model with detailed packet-level simulations for the scenarios considered in this paper. The execution time of the mixed model is significantly impacted by the frequency with which the analytical model must be solved in response to changes in the data rate at the interface of the packet-level and analytical models. We present a time averaging approach to mitigate this impact and present the results of the resulting tradeoff between prediction accuracy and model execution time.
Electron-Beam-Induced-Current Investigation of GaN/AlGaN/Si Heterostructures Using Scanning Transmission Electron Microscopy (2007)

An electron-beam-induced-current technique has been applied to scanning transmission electron microscopy to characterize GaN/AlGaN/n-Si heterostructures. The structure was formed by metalorganic vapor phase epitaxy using AlGaN as an intermediate layer. Two samples with nominal intermediate layer thicknesses of 60 and 120 nm were studied. It was found that there is a junction in the n-type Si region underneath the nitride/Si interface irrespective of the intermediate layer thickness, whereas induced current occurred neither in the nitride region nor at the nitride/Si interface. The junction formed was found to be undulated. The sample with the thin intermediate layer had undulations of a shorter periodicity than that with the thick intermediate layer. The formation of the junction is attributed to the diffusion of Al during the nitride growth.
Integrated multilayer GaAs lasers separated by tunnel junctions (1982)

An integrated multilayer laser consisting of three double heterostructure GaAs laser diodes connected in series by reversed biased p+n+ tunnel junctions have been grown by molecular beam epitaxy. The lasers operate at currents comparable to single double heterostructure lasers but at approximately three times the single laser voltage.
The Dipole Moments, Ultraviolet Spectra and Structure of Azo-bis-(chloroformamidine) and Azo-bis-(nitroformamidine) (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Dipole Moments, Ultraviolet Spectra and Structure of Azo-bis-(chloroformamidine) and Azo-bis-(nitroformamidine)W. D. KumlerCite this: J. Am. Chem. Soc. 1953, 75, 13, 3092–3093Publication Date (Print):July 1, 1953Publication History Published online1 May 2002Published inissue 1 July 1953https://pubs.acs.org/doi/10.1021/ja01109a013https://doi.org/10.1021/ja01109a013research-articleACS PublicationsRequest reuse permissionsArticle Views43Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A COMPARISON OF FLUORESCENCE METHODS USED IN THE PHARMACOKINETIC STUDIES OF Zn(II)PHTHALOCYANINE IN MICE (1991)

The pharmacokinetics of Zn phthalocyanine (ZnPc) encapsulated in dipalmitoyl-phosphatidylcholine (DPPC) liposomes, injected intravenously in Skh:HR-1 nude mice, was monitored by two in vitro techniques and one in vivo technique, all based on fluorescence spectroscopy. The in vitro methods involve either fluorescence measurements on thin tissue sections or on extracts from these tissues. The in vivo method involves the fluorescence measurement at the skin surface. Both in vitro techniques gave similar results which are consistent with previous findings on the pharmacokinetic behavior of ZnPc. The liver and spleen showed rapid ZnPc concentration increases, reaching a maximum level in 30 min. or less post drug administration. Relatively little ZnPc was detected in the skin, fat or muscle, the maximum concentration occurring at 12 h. In vivo fluorescence reached a maximum intensity approx. 6 h post injection at the mid-chest analysis site and at 12 h in the thigh. The in vivo measurements at two different anatomical sites showed pharmacokinetic behavior that reflects an overall integrated fluorescence originating from several tissue sites.
Do Interictal Spikes Drive Epileptogenesis? (2005)

Interictal spikes are periodic, very brief bursts of neuronal activity that are observed in the electroencephalogram of patients with chronic epilepsy. These spikes are useful diagnostically, but we do not know why they are so strongly associated with the spontaneous seizures that characterize chronic epilepsy. Interictal spikes appear before the first spontaneous seizures in animal models of acquired epilepsy, and spikes are sufficient to induce long-term changes in synaptic connections between neurons. Thus, spikes may guide the development of the neuronal circuits that initiate spontaneous seizures. If so, then attempts to prevent or cure epilepsy may best be directed at spikes rather than seizures.
Suppression of FVIII Inhibitor Formation in Hemophilic Mice by Delivery of Transgene Modified Apoptotic Fibroblasts (2009)

The development of inhibitory antibodies to factor VIII (FVIII) is currently the most significant complication of FVIII replacement therapy in the management of patients with severe hemophilia A. Immune tolerance protocols for the eradication of inhibitors require daily delivery of intravenous FVIII for at least 6 months and are unsuccessful in 20-40% of treated patients. We hypothesize that tolerance can be induced more efficiently and reliably by delivery of FVIII antigen within autologous apoptotic cells (ACs). In this study, we demonstrated suppression of the T cell and inhibitor responses to FVIII by infusion of FVIII expression vector modified apoptotic syngeneic fibroblasts in both naive and preimmunized hemophilia A mice. ACs without FVIII antigen exerted modest generalized immune suppression mediated by anti-inflammatory signals. However, FVIII expressing apoptotic syngeneic fibroblasts produced much stronger antigen-specific immune suppression. Mice treated with these fibroblasts generated CD4+ T cells that suppressed the immune response to FVIII after adoptive transfer into naive recipients and antigen-specific CD4+CD25+ regulatory T cells (Tregs) that inhibited the proliferation of FVIII responsive effector T cells in vitro. These preclinical results demonstrate the potential for using FVIII vector modified autologous ACs to treat high-titer inhibitors in patients with hemophilia A.
Phage antibody display libraries: a powerful antibody discovery platform for immunotherapy (2014)

Phage display technology (PDT), a combinatorial screening approach, provides a molecular diversity tool for creating libraries of peptides/proteins and discovery of new recombinant therapeutics. Expression of proteins such as monoclonal antibodies (mAbs) on the surface of filamentous phage can permit the selection of high affinity and specificity therapeutic mAbs against virtually any target antigen. Using a number of diverse selection platforms (e.g. solid phase, solution phase, whole cell and in vivo biopannings), phage antibody libraries (PALs) from the start point provides great potential for the isolation of functional mAb fragments with diagnostic and/or therapeutic purposes. Given the pivotal role of PDT in the discovery of novel therapeutic/diagnostic mAbs, in the current review, we provide an overview on PALs and discuss their impact in the advancement of engineered mAbs.
In Vitro and In Vivo Anti Lymphoma Effect of GX15-070 in Mantle Cell Lymphoma. (2006)

Abstract Introduction Mantle cell lymphoma (MCL), an incurable B cell lymphoma, consistently over expresses bcl-2 despite not carrying the t(14;18). The attenuation of apoptosis by bcl-2 is thought to contribute to the malignant process and increase resistance to some cytotoxic agents. We recently demonstrated that GX15-070, a small molecular inhibitor of the BH3 binding groove of bcl-2, has activity against MCL cell lines in vitro. We set out to assess the effect of GX15-070 alone and in combination with Vincristine on the viability of MCL cells in vitro and in vivo. Methods 3 previously characterized bcl-2 over expressing MCL cell lines (JVM-2, Hbl-2, granta) were used. Cells were grown in standard media and exposed to a range of concentrations of GX15-070 with and without Vincristine. Dose-response was assessed by measuring viability at 48 hours using the WST-1 assay. In vivo experiments were conducted on immune deficient mice in which 5×106 cells were injected in the flank then treated IV with GX15-070 (q 2days × 5 doses), Vincristine (q4 days × 3 doses) or both starting 5 days later. Tumours were measured three times weekly. Results All three MCL cell lines over-expressed bcl-2 by western blot. Each MCL cell line showed sensitivity to GX15-070 at a range of concentrations. The addition of GX15-070 to low dose Vincristine (10−6) caused significant growth inhibition of each MCL cell line (see table 1). Discussion Our results demonstrate that using GX15-070 to target bcl-2 is an effective anti neoplastic approach against MCL cell lines in vitro. In addition, our results suggest that combining Vincristine and GX15-070 is a promising strategy in treating MCL. In vivo experiments to confirm this additive activity are still ongoing and will be presented in full. Initial impressions suggest that there is a rationale for the addition of GX15-070 to current cytotoxic regimens used to treat MCL in the setting of clinical trials. Table 1: Effect of Vincristine and GX15-070 on in vitro growth of 3 MCL cell lines Growth as % age of Control Cell Line JVM-2 HBL-2 Granta Vincristine alone (10-6 mg/ml) 92% 48% 89% GX15-070 alone (0.08 uM) 75% 76% 60% Vincristine 10-6 mg/ml and GX15-070 0.08 uM 52% 24% 52%
The Impact of a Batterers' Program on Battered Women (1999)

<i>Twenty-five in-depth interviews were conducted with battered women whose partners had completed a batterers' intervention program (BIP) that was administered by a women's shelter in a Canadian urban setting. Interview questions broadly explored women's experiences with the BIP, including what, if any, differences they perceived after their partners completed intervention, and how the women accounted for such changes. Respondents reported a variety of experiences, most of which appeared beneficial for them. Major themes were (a) feelings of enhanced safety, (b) a sense of enhanced personal well-being, (c) feeling validated by program counselors, and (d) increased knowledge regarding abusive behaviors.</i>
School of Nursing alumna on frontline of global battle to cure (2008)

Mary Ellen Simpson ’91 hoped her nursing degree would help her make a difference in the world.
Transmit diversity and transmit adaptive arrays for broadband mobile OFDM systems (2005)

This paper explores the performance of several frequency-domain transmit array processing strategies for broadband mobile turbo-coded OFDM systems. We consider transmit adaptive array (TXAA) techniques (also known as maximal ratio transmission) with various assumptions on mobile- to-base channel response feedback in a two-transmit antenna OFDM system. We compare the performance of such techniques with the well-known Alamouti diversity scheme, which requires no channel response knowledge at the transmitter. The various techniques are compared with both simulated channels and with channel responses measured with an experimental broadband mobile MIMO-OFDM system. With perfect instantaneous feed- back of the matrix frequency response, the TXAA schemes have the expected 3 dB gain over the Alamouti scheme. However, if the transmit array cannot track the time and frequency selectiv- ity of the channel, the Alamouti method can in some cases out- perform the transmit adaptive array techniques.
Nerves of the heart: a comprehensive review with a clinical point of view (2009)

The heart is an organ which main characteristic is its autonomy of function. Therefore, it is possible to develop elementary experiments such as extirpating the heart of a frog (Bufo amenarum), which during a certain amount of time keeps beating and even responding to brady- or tachycardian chemical stimulations. The underlying cause of this phenomenon is the action of specific solutions, which shower the mentioned organ. However, inside the organism, it adapts its functions to the somatic reality and to the specific moment of that soma. These conducts are instrumented by a complex system of information gathering, the adoption of central nervous system’s function standards, and the production of functional responses suitable for the different possible situations. All these functions are related to cardiac innervation.
Rearrangeable multichannel free-space optical switch using polarisation multiplexing technique (1990)

A rearrangeable multichannel free-space optical switch using polarisation multiplexing technique is described. A 32-channel optical switch is constructed and its performances are confirmed.
A School-Based Approach to Early Identification and Management of Students with ADHD (2007)

Attention-deficit/hyperactivity disorder (ADHD) is one of the most challenging chronic conditions for children, families, schools, and physicians. Because symptoms of ADHD can be mistaken for other health conditions and misdiagnosis can occur, accurate diagnosis and treatment require comprehensive evaluation. This article introduces a school-based framework- ADHD Identification and Management in Schools (AIMS)-developed by a multidisciplinary team composed of a pediatrician, school nurses, and school psychologists that sought to improve communication between school personnel and physicians, standardize practice, and improve the quality of care for children with ADHD. The framework provides school nurses with an evidence-based, systematic method for early identification and management of children with ADHD.
Smoking decreases the level of circulating CD34+ progenitor cells in young healthy women - a pilot study (2010)

The number of CD34 + progenitor cells positively correlates with FMD in young healthy women and is decreased by smoking.
Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression (2011)

There is growing evidence suggesting that antagonists of group II metabotropic glutamate receptors (mGluR2/3) exhibit antidepressant-like properties in several preclinical models of depression. However, all those studies have been performed using competitive group II non-selective orthosteric antagonists. In this study we extensively characterized a group II selective negative allosteric modulator (4-[3-(2,6-Dimethylpyridin-4-yl)phenyl]-7-methyl-8-trifluoromethyl-1,3-dihydrobenzo[b][1,4]diazepin-2-one, namely RO4491533, Woltering et al., 2010) in several in vitro biochemical assays and in vivo models of depression. In vitro, RO4491533 completely blocked the glutamate-induced Ca(2+) mobilization and the glutamate-induced accumulation in [(35)S]GTP(γS) binding in cells expressing recombinant human or rat mGluR2 and in native tissues. Results from Schild plot experiments and reversibility test at the target on both cellular and membrane-based assays confirmed the negative allosteric modulator properties of the compound. RO4491533 was equipotent on mGluR2 and mGluR3 receptors but not active on any other mGluRs. RO4491533 has acceptable PK properties in mice and rats, is bioavailable following oral gavage (F = 30%) and brain-penetrant (CSF conc/total plasma conc ratio = 0.8%). RO4491533 appeared to engage the central mGluR2 and mGluR3 receptors since the compound reversed the hypolocomotor effect of an mGluR2/3 orthosteric agonist LY379268 in a target-specific manner, as did the group II orthosteric mGluR2/3 antagonist LY341495. RO4491533 and LY341495 dose-dependently reduced immobility time of C57Bl6/J mice in the forced swim test. Also, RO4491533 and LY341495 were active in the tail suspension test in a line of Helpless (H) mice, a putative genetic model of depression. These data suggest that mGluR2/3 receptors are viable targets for development of novel pharmacotherapies for depression.
The Oxidation of Haemoglobin (1984)

The literature data on the oxidation of human haemoglobin and the haemoglobin of other vertebrates in the form of complexes with ligands and in the free state are surveyed. The relation between conformational changes in oxyhaemoglobin and the rate of its autoxidation as well as the role of the chemical factors influencing the conformation of the protein, the active centre, and the rate of oxidation of haemoglobin are emphasised. The bibliography includes 121 references.
Some randomness properties of cascaded sequences (Corresp.) (1980)

The autonomous response sequences of cascade coupled sequence generators are investigated. The <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</tex> -tuple distribution and autocorrelation function of such sequences are related to the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</tex> -tuple distribution of the component sequences. Cascade coupled pseudonoise (PN) sequence generators with <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</tex> cumpunents have output sequences with an <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</tex> -tuple distribution that approximates the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</tex> -tuple distribution of a random sequence in which the probability of a one is <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2^{-t}</tex> . The phase shifts are almost uncorrelated for most shifts, but some shifts are highly correlated.
Gradient elution for micellar electrokinetic capillary chromatography (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGradient elution for micellar electrokinetic capillary chromatographyAnthony T. Balchunas and Michael J. SepaniakCite this: Anal. Chem. 1988, 60, 7, 617–621Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/ac00158a003https://doi.org/10.1021/ac00158a003research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations117LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The K1 capsule modulates trafficking of E. coli-containing vacuoles and enhances intracellular bacterial survival in human brain microvascular endothelial cells (2003)

Escherichia coli K1 has been shown to invade human brain microvascular endothelial cells (HBMEC) in vitro and translocate the blood-brain barrier in vivo, but it is unclear how E. coli K1 traverses HBMEC. We have previously shown that internalized E. coli K1 is localized within membrane-bound vacuole in HBMEC. The present study was carried out to understand intracellular trafficking of E. coli K1 containing vacuoles (ECVs) in HBMEC. ECVs initially acquired two early endosomal marker proteins, EEA1 and transferrin receptor. Rab7 and Lamp-1, markers for late endosome and late endosome/lysosome, respectively, were subsequently recruited on the ECVs, which was confirmed with flow cytometry analysis of ECVs. However, ECVs did not obtain cathepsin D, a lysosomal enzyme, even after 120 min incubation, suggesting that E. coli K1 avoids lysosomal fusion. In contrast, isogenic K1 capsule-deletion mutant obtained early and late endosomal markers on vacuolar membranes and allowed lysosomal fusion with subsequent degradation inside vacuoles. This observation was consistent with the decreased intracellular survival of K1 capsule-deletion mutant, even though the binding and internalization rates of the mutant were higher than those of the parent E. coli K1 strain. This is the first demonstration that E. coli K1, via the K1 capsule on the bacterial surface, modulates the maturation process of ECVs and prevents fusion with lysosomes, which is an event necessary for traversal of the blood-brain barrier as live bacteria.