gebhart/patrepeval huggingface dataset:
Biographical notice of Sir Henry A. Miers (1858-1942) (1944)

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Both FA- and mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution (2011)

Both folic acid (FA)- and methoxypoly(ethylene glycol) (mPEG)-conjugated chitosan nanoparticles (NPs) had been designed for targeted and prolong anticancer drug delivery system. The chitosan NPs were prepared with combination of ionic gelation and chemical cross-linking method, followed by conjugation with both FA and mPEG, respectively. FA-mPEG-NPs were compared with either NPs or mPEG-/FA-NPs in terms of their size, targeting cellular efficiency and tumor tissue distribution. The specificity of the mPEG-FA-NPs targeting cancerous cells was demonstrated by comparative intracellular uptake of NPs and mPEG-/FA-NPs by human adenocarcinoma HeLa cells. Mitomycin C (MMC), as a model drug, was loaded to the mPEG-FA-NPs. Results show that the chitosan NPs presented a narrow-size distribution with an average diameter about 200 nm regardless of the type of functional group. In addition, MMC was easily loaded to the mPEG-FA-NPs with drug-loading content of 9.1%, and the drug releases were biphasic with an initial burst release, followed by a subsequent slower release. Laser confocal scanning imaging proved that both mPEG-FA-NPs and FA-NPs could greatly enhance uptake by HeLa cells. In vivo animal experiments, using a nude mice xenograft model, demonstrated that an increased amount of mPEG-FA-NPs or FA-NPs were accumulated in the tumor tissue relative to the mPEG-NPs or NPs alone. These results suggest that both FA- and mPEG-conjugated chitosan NPs are potentially prolonged drug delivery system for tumor cell-selective targeting treatments.
Rearrangement of rat immunoglobulin E heavy-chain and c-myc genes in the B-cell immunocytoma IR162. (1987)

Mammalian B-cell lymphoid malignancies frequently display aberrant translocations involving the c-myc proto-oncogene and one of the immunoglobulin loci. We have observed and characterized such a translocation in the immunoglobulin E-producing rat immunocytoma IR162 by using recombinant DNA technology. We show here for the first time that a c-myc gene has recombined with the excluded allele of the nonfunctional epsilon heavy-chain immunoglobulin gene. This recombination has resulted in the loss of 5'-proximal DNA and, consequently, potential regulatory information from the body of the c-myc structural gene via joining to the epsilon heavy-chain switch region in a head-to-head, i.e., 5'-to-5', configuration. As discussed in this report, these results, together with the previous results of others, have important implications for immunoglobulin heavy-chain class switching mechanisms controlling normal and abnormal translocations.
C—H Bond Functionalization in Complex Organic Synthesis (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
The effect of a radiant heat dressing on pressure ulcers (2000)

The use of heat in wound healing has been demonstrated to aid oxygen flow and hence healing in acute wounds. However, the situation in chronic wounds is less clear. This study was designed to investigate the benefits of using a radiant heat therapy system in the treatment of Stage 3 and 4 pressure ulcers. Despite randomisation, patients receiving radiant heat therapy were more infirm than those receiving standard treatment. This prospective, single-centre, randomised trial resulted in an accelerated rate of healing for those receiving heat therapy compared to a standard treatment: time difference to 75% of original area = 6.4 days (p = 0.057), to 50% of original area = 9.6 days (p = 0.039), time to 25% = 7.2 days (p = 0.01). This new development warrants further investigation to fully assess the role of a thermoregulation system in chronic wound healing.
A Deep Look Beneath Tall Mountains (1999)

Geologists are adept at scratching the surface, but they have trouble delving into deep mysteries. That's because they can only collect rocks from the topmost parts of the 40 kilometers of crust floating on the underlying mantle, and those surface rocks had seemed unlikely to reveal much about deep-seated geological processes. But now, mineralogists at the University of California, Riverside (UCR), have new evidence that a large chunk of rock high in the Alps may have originated hundreds of kilometers underground. If so, it may have brought some of those deep secrets to the surface.
Magnetics of nonlaminated, bilaminated, and multilaminated permalloy stripes (1988)

Using the magnetoresistive response technique and the micro-Kerr domain imaging technique, we have studied the magnetics of 2000-Å-thick nonlaminated, bilaminated, and multilaminated permalloy stripes with a length of 2400 μm, widths varying from 100 to 2 μm, and with the uniaxial anisotropy easy axis transverse to the length of the stripes. Results show that stripes from all three types of films exhibit non-single-domain remanent states that are hysteretic in their longitudinal magnetic responses. For the nonlaminated structures, closure domains are formed for the minimization of transverse demagnetization energy. For the laminated structures, longitudinally magnetized regions along the edges are formed as a basic feature of the flux-closure configuration in the laminated films. Furthermore, for the multilaminated structures, the large number of degrees of freedom and the low wall energies have created an abundance of low-energy remanent states that might cause the small-field response of the structure to creep with time. Finally, the use of transverse biasing is found to be ineffective in eliminating hysteresis in the bilaminated structures because this hysteresis is not a consequence of transverse symmetry in the structure.
Recent Advances in Microfluidic Detection Systems (2009)

There are numerous detection methods available for microfluidic analyses. Both conventional and novel detection methods are being put to use for detection on these miniaturized systems, with the analyte of interest driving the choice of detection method. In this article, we summarize microfluidic-based detection strategies from the last 2 years. More focus is given to unconventional approaches to detection routes and novel strategies for performing high-sensitivity detection.
Mood disorders and fertility in women: a critical review of the literature and implications for future research (2007)

A medline literature review of fertility and mood disorder articles published since 1980 was performed in order to critically review the literature regarding a relationship between mood disorders, fertility and infertility treatment. Previous studies suggests that mood disorders, both in the bipolar and unipolar spectrum, may be associated with decreased fertility rates. Most studies report that women seeking treatment for infertility have an increased rate of depressive symptoms and possibly major depression (none showed evaluated mood elevations). Many, but not all, studies found that depressive symptoms may decrease the success rate of fertility treatment. Treatments for infertility may independently influence mood through their effects on estrogen and progesterone, which have been shown to influence mood through their actions on serotonin. Studies are limited in scope and confounding variables are many, limiting the strength of the results. In conclusion, a range of existing studies suggests that fertility and mood disorders are related in a complex way. Future studies should use clinical interviews and standardized and validated measures to confirm the diagnosis of mood disorders and control for the variables of medication treatment, desire for children, frequency of sexual intercourse, age, FSH levels, menstrual cycle regularity in assessing an interrelationship between mood disorders and fertility.
Postmoderne — Eine Zwischenbilanz (1989)

1954 hat Arnold Toynbee seine kulturmorphologische Prognose, daß die Vorherrschaft des Westens durch den Aufstieg des Ostens und des pazifischen Raums abgelöst werde, dahingehend zusammengefaßt, daß nun die Moderne beendet sei und die Postmoderne anbreche.
Therapeutic potential of naringin: an overview (2016)

Naringin is a promising candidate for further in vivo studies and clinical use. More detailed studies regarding its mechanism of action are required.
Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice (2013)

EFA ameliorate STZ induced diabetes in mice.
Different susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans. Effects of N-acetylcysteine administration. (1992)

The data indicate that the susceptibility to the development of nitrate tolerance in humans is higher in the venous than in the arterial circulation, and that the sulfhydryl group donor N-acetylcysteine is extremely effective in reversing nitroglycerin tolerance in the venous circulation in humans.
Alternative algorithm for maximum likelihood DOA estimation and detection (1994)

The majority of algorithms developed for the narrowband direction of arrival (DOA) estimation problem rely on an eigenvalue decomposition (EVD) to determine both the number of signals and their respective DOAs. An alternative algorithm is presented that solves both the DOA detection and estimation problems without resorting to an EVD. The algorithm is shown to have asymptotically equivalent performance to that of the (unconditional) maximum likelihood method, and hence it yields asymptotically minimum variance DOA estimates. The computational complexity required to update the DOA estimates in response to additional data from the array is investigated, and the algorithm is shown to be somewhat simpler than other methods with comparable performance. In addition, the asymptotic distribution of the algorithm's cost function is derived, and is shown to be composed of the sum of two differently scaled chi-squared random variables. A hypothesis test for determining the number of signals based on this result is then presented.
Rapid Detection and Differentiation of Antibodies to HIV-1 and HIV-2 Using Multivalent Antigens and Magnetic Immunochromatography Testing (2010)

A simplified lateral-flow assay for the detection of antibodies to HIV using magnetic-bead conjugates and multibranched peptides from both HIV-1 and HIV-2 was developed. Magnetic immunochromatography testing (MICT) uses a standard lateral-flow platform that incorporates magnetic-bead conjugates for quantitative measurement of the magnetic field distortion associated with the bound magnetic conjugate (reported as adjusted relative magnetic units [MAR]). The results of the optimized MICT assay were compared to standard enzyme immunoassay (EIA) and Western blotting (WB) results using a blinded 649-member panel of specimens from the United States, Cameroon, and West Africa. The panel was comprised of samples from individuals infected with various HIV-1 subtypes (n = 234) or HIV-2 (n = 65) and HIV-seronegative specimens (n = 350). Additionally, 13 HIV-1 seroconversion panels (total specimens = 85), a worldwide panel containing seven of the major circulating HIV-1 subtypes (n = 18), an HIV-2 panel, an HIV-1/HIV-2 mixed panel, and 100 prospective specimens were tested with completely concordant results. Assay reproducibility (observed MAR) for both intra- and interrun testing was excellent, with coefficients of variation of <12%. MICT can provide a rapid, low-cost method of determining HIV antibody status requiring no subjective interpretations.
Thermal Fatigue Behavior of Air-Plasma Sprayed Thermal Barrier Coating with Bond Coat Species in Cyclic Thermal Exposure (2013)

The effects of the bond coat species on the delamination or fracture behavior in thermal barrier coatings (TBCs) was investigated using the yclic thermal fatigue and thermal-shock tests. The interface microstructures of each TBC showed a good condition without cracking or delamination after flame thermal fatigue (FTF) for 1429 cycles. The TBC with the bond coat prepared by the air-plasma spray (APS) method showed a good condition at the interface between the top and bond coats after cyclic furnace thermal fatigue (CFTF) for 1429 cycles, whereas the TBCs with the bond coats prepared by the high-velocity oxygen fuel (HVOF) and low-pressure plasma spray (LPPS) methods showed a partial cracking (and/or delamination) and a delamination after 780 cycles, respectively. The TBCs with the bond coats prepared by the APS, HVOF and LPPS methods were fully delaminated (>50%) after 159, 36, and 46 cycles, respectively, during the thermal-shock tests. The TGO thickness in the TBCs was strongly dependent on the both exposure time and temperature difference tested. The hardness values were found to be increased only after the CFTF, and the TBC with the bond coat prepared by the APS showed the highest adhesive strength before and after the FTF.
California scaly bark disease of citrus: No known cure for infected trees but treatment in early stages of disease can retard its advance into successive stages with their increasing economic loss (1957)

Psorosis—scaly bark—is the primary killer of citrus trees in California.
Rectal Indomethacin Prevents Moderate to Severe Post-ERCP Pancreatitis and Death and Should Be Used Before the Procedure: A Meta-Analysis of Aggregate Subgroup Data (2018)

Rectal indomethacin significantly decreases the occurrence of moderate to severe PEP and death in all patients, only if given before the procedure.
Synthesis of Monodisperse Iron Oxide Nanoparticles without Surfactants (2014)

Monodisperse iron oxide nanoparticles could be successfully synthesized with two kinds of precipitants through a precipitation method. As‐prepared nanoparticles in the size around 10 nm with regular spherical‐like shape were achieved by adjusting pH values. NaOH and NH 3 ·H 2 O were used as two precipitants for comparison. The average size of nanoparticles with NH 3 ·H 2 O precipitant got smaller and represented better dispersibility, while nanoparticles with NaOH precipitant represented better magnetic property. This work provided a simple method without using any organic solvents, organic metal salts, or surfactants which could easily obtain monodisperse nanoparticles with tunable morphology.
Timestamp Temporal Logic (TTL) for Testing the Timing of Cyber-Physical Systems (2017)

In order to test the performance and verify the correctness of Cyber-Physical Systems (CPS), the timing constraints on the system behavior must be met. Signal Temporal Logic (STL) can efficiently and succinctly capture the timing constraints of a given system model. However, many timing constraints on CPS are more naturally expressed in terms of events on signals. While it is possible to specify event-based timing constraints in STL, such statements can quickly become long and arcane in even simple systems. Timing constraints for CPS, which can be large and complex systems, are often associated with tolerances, the expression of which can make the timing constraints even more cumbersome using STL. This paper proposes a new logic, Timestamp Temporal Logic (TTL), to provide a definitional extension of STL that more intuitively expresses the timing constraints of distributed CPS. TTL also allows for a more natural expression of timing tolerances. Additionally, this paper outlines a methodology to automatically generate logic code and programs to monitor the expressed timing constraints. Since our TTL monitoring logic evaluates the timing constraints using only the timestamps of the required events on the signal, the TTL monitoring logic has significantly less memory footprint when compared to traditional STL monitoring logic, which stores the signal value at the required sampling frequency. The key contribution of this paper is a scalable approach for online monitoring of the timing constraints. We demonstrate the capabilities of TTL and our methodology for online monitoring of TTL constraints on two case studies: 1) Synchronization and phase control of two generators and, 2) Simultaneous image capture using distributed cameras for 3D image reconstruction.
Phase formation and dissociation in the thin-film Pt/Al system (1987)

Phase formation has been investigated in the following thin-film systems: Al/Pt, Pt2Al/Al, Pt8Al21/Pt, Pt/PtAl, and Pt/Pt5Al21/Al, between 225 and 550 °C. The films were prepared by sequential evaporation and coevaporation, annealed under vacuum, and analyzed by Rutherford backscattering and x-ray diffraction. In all cases, except for Pt/PtAl, the initial phase formed was Pt2Al3, followed by the more Pt- or Al-rich phases, depending on the overall stoichiometry. Al is the dominant moving species during the formation of Pt2Al3.
A Non-invasive and Real-time Monitoring of the Regulation of Photosynthetic Metabolism Biosensor Based on Measurement of Delayed Fluorescence in Vivo (2007)

In this paper, a new principle biosensor for non-invasive monitoring of theregulation of photosynthetic metabolism based on quantitative measurement of delayedfluorescence (DF) is developed. The biosensor, which uses light-emitting diode lattice asexcitation light source and a compact Single Photon Counting Module to collect DF signal,is portable and can evaluate plant photosynthesis capacity in vivo. Compared with itsprimary version in our previous report, the biosensor can better control environmentalfactors. Moreover, the improved biosensor can automatically complete the measurements oflight and CO2 response curves of DF intensity. In the experimental study, the testing of theimproved biosensor has been made in soybean (Glycine max Zaoshu No. 18) seedlingstreated with NaHSO3 to induce changes in seedlings growth and photosynthetic metabolism.Contrast evaluations of seedlings photosynthesis were made from measurements of netphotosynthesis rate (Pn) based on consumption of CO2 in tested plants. Current testingresults have demonstrated that the improved biosensor can accurately determine theregulatory effects of NaHSO3 on photosynthetic metabolism. Therefore, the biosensorpresented here could be potential useful for real-time monitoring the regulatory effects ofplant growth regulators (PGRs) and other exogenous chemical factors on plant growth andphotosynthetic metabolism.
Attempts towards derivation and establishment of bovine embryonic stem cell-like cultures (2004)

Current knowledge on the biology of mammalian embryonic stem cells (ESC) is stunningly sparse in light of their potential value in studies of development, functional genomics, generation of transgenic animals and human medicine. Despite many efforts to derive ESC from other mammalian species, ESC that retain their capacity for germ line transmission have only been verified in the mouse. However, the criterion of germ line transmission may not need to be fulfilled for exploitation of other abilities of these cells. Promising results with human ESC-like cells and adult stem cells have nourished great expectations for their potential use in regenerative medicine. However, such an application is far from reality and substantial research is required to elucidate aspects of the basic biology of pluripotent cells, as well as safety issues associated with the use of such cells in therapy. In this context, methods for the derivation, propagation and differentiation of ESC-like cultures from domestic animals would be highly desirable as biologically relevant models. Here, we review previously published efforts to establish bovine ESC-like cells and describe a procedure used in attempts to derive similar cells from bovine Day 12 embryos.
Performance of adaptive linear interference suppression for DS-CDMA in the presence of flat Rayleigh fading (2002)

The performance of adaptive linear interference suppression for direct-sequence code-division multiple-access is evaluated in the presence of flat Rayleigh fading. Interference suppression is achieved with an adaptive digital filter which attempts to minimize the mean squared estimation error. A model for the reverse link of a cellular system is assumed which accounts for both intra- and other-cell interference, and stochastic arrivals and departures of transmitted packets. All received signals experience both long-term shadowing and short-term Rayleigh fading. Variations on decision-directed and blind least squares adaptive algorithms are presented which are compatible with differential coding and detection. Computer simulation results are presented which compare the uncoded performance of the adaptive scheme with the conventional matched filter. These results indicate that the adaptive approach is insensitive to variations in received power (averaged over fades), and offers a significant gain in capacity (measured in Erlangs per cell) at modest to high error rates (5-15%).
Radiation characteristics of the short dielectric rod antenna: A numerical solution (1987)

The problem of the dielectric rod antenna is studied numerically. The surface integral equation is used to simulate the problem in its actual form. From the surface currents induced on the antenna surface, the far-field radiation patterns are calculated. Different parameters are considered, such as the extension of the dielectric from the waveguide aperture, the waveguide and the dielectric diameter, the dielectric constant and finally the effect of shaping of the dielectric end. The performance of the antenna as a feed for the reflector antenna is also studied by calculating the gain factor, spillover efficiency and the phase center location of the feed. Some of the results are compared with the available experimental data of Dombek. The agreement is found to be excellent.
A LabVIEW® based generic CT scanner control software platform (2010)

UGCT, the Centre for X-ray tomography at Ghent University (Belgium) does research on X-ray tomography and its applications. This includes the development and construction of state-of-the-art CT scanners for scientific research. Because these scanners are built for very different purposes they differ considerably in their physical implementations. However, they all share common principle functionality. In this context a generic software platform was developed using LabVIEW® in order to provide the same interface and functionality on all scanners. This article describes the concept and features of this software, and its potential for tomography in a research setting. The core concept is to rigorously separate the abstract operation of a CT scanner from its actual physical configuration. This separation is achieved by implementing a sender-listener architecture. The advantages are that the resulting software platform is generic, scalable, highly efficient, easy to develop and to extend, and that it can be deployed on future scanners with minimal effort.