gebhart/patrepeval huggingface dataset:
An adenovirus type 5 early region 1B-encoded CTL epitope-mediating tumor eradication by CTL clones is down-modulated by an activated <i>ras</i> oncogene. (1995)

Mouse embryo cells (C57BL/6, H-2b) transformed by the E1A and E1B genes of adenovirus type 5 (Ad5E1 MEC) are highly immunogenic. Previously, CTL were cloned from mice immunized with Ad5E1 MEC. These CTL clones were capable of tumor eradication in nude mice, and were directed against the Ad5E1A-encoded decapeptide SGPSNTPPEI, presented by the H-2Db MHC molecule. We have now generated Ad5E1 MEC containing a mutated Ad5E1A-encoded epitope. The mutant Ad5E1 MEC induce a strong CTL response when injected into immunocompetent mice. CTL clones generated against mutant Ad5E1-transformed tumor cells recognize an Ad5E1B-encoded epitope (VNIRNCCYI) in the context of H-2Db. Because this epitope is also present on wild-type Ad5E1 MEC, it is concluded that Ad5E1-transformed tumor cells express at least two CTL epitopes. Interestingly, the lysis of Ad5E1 MEC by the Ad5E1B-specific, but not by the Ad5E1A-specific, CTL clones was strongly diminished by the action of the activated ras oncogene. CTL directed against the Ad5E1B-encoded epitope were, like Ad5E1A-specific CTL, able to eradicate large established Ad5E1-induced tumors in B6 nude mice, demonstrating that CTL activity directed against different CTL epitopes expressed by the same tumor can be exploited for immunotherapy of cancer.
High performance PIN Ge photodetector and Si optical modulator with MOS junction for photonics-electronics convergence system (2013)

We report on a high speed silicon-waveguide-integrated PIN Ge photodetector of 45 GHz bandwidth, and a high efficiency of 0.3 V·cm silicon optical modulator with a metal-oxide-semiconductor (MOS) junction by applying the low optical loss and high conductivity poly-silicon gate. These OE/EO devices enable low drive voltage of around 1V, which would contribute to a high density optical interposer of the future photonics-electronics convergence system.
Galvanic analysis (1964)

P. Hersch, Proc. Soc. Anal. Chem., 1964, 1, 87 DOI: 10.1039/SA9640100087
A Comparison of Multivariable Control Design Techniques for a Turbofan Engine Control (1995)

This paper compares two previously published design procedures for two different multivariable control design techniques for application to a linear engine model of a jet engine. The two multivariable control design techniques compared were the Linear Quadratic Gaussian with Loop Transfer Recovery (LQG/LTR) and the H–Infinity (H∞) synthesis. The two control design techniques were used with specific previously published design procedures to synthesize controls which would provide equivalent closed loop frequency response for the primary control loops while assuring adequate loop de-coupling. The resulting controllers were then reduced in order to minimize the programming and data storage requirements for a typical implementation. The reduced order linear controllers designed by each method were combined with the linear model of an advanced turbofan engine and the system performance was evaluated for the continuous linear system. Included in the performance analysis are the resulting frequency and transient responses as well as actuator usage and rate capability for each design method. The controls were also analyzed for robustness with respect to structured uncertainties in the unmodeled system dynamics. The two controls were then compared for performance capability and hardware implementation issues.
Therapeutics for cognitive aging (2010)

This review summarizes the scientific talks presented at the conference "Therapeutics for Cognitive Aging," hosted by the New York Academy of Sciences and the Alzheimer's Drug Discovery Foundation on May 15, 2009. Attended by scientists from industry and academia, as well as by a number of lay people-approximately 200 in all-the conference specifically tackled the many aspects of developing therapeutic interventions for cognitive impairment. Discussion also focused on how to define cognitive aging and whether it should be considered a treatable, tractable disease.
Software News and Updates CHARMM-GUI: A Web-Based Graphical User Interface for CHARMM (2008)

Abstract: CHARMM is an academic research program used widely for macromolecular mechanics and dynamicswith versatile analysis and manipulation tools of atomic coordinates and dynamics trajectories. CHARMM-GUI,http://www.charmm-gui.org, has been developed to provide a web-based graphical user interface to generate variousinput ﬁles and molecular systems to facilitate and standardize the usage of common and advanced simulation techni-ques in CHARMM. The web environment provides an ideal platform to build and validate a molecular model sys-tem in an interactive fashion such that, if a problem is found through visual inspection, one can go back to the pre-vious setup and regenerate the whole system again. In this article, we describe the currently available functionalmodules of CHARMM-GUI Input Generator that form a basis for the advanced simulation techniques. Future direc-tions of the CHARMM-GUI development project are also discussed brieﬂy together with other features in theCHARMM-GUI website, such as Archive and Movie Gallery.q 2008 Wiley Periodicals, Inc. J Comput Chem 29: 1859–1865, 2008Key words: molecular dynamics; Poisson-Boltzmann; electrostatic potential; membrane; visualization; explicit sol-vent; implicit solvent; MarvinSpace
Detection of early pregnancy in sheep by the rosette inhibition test (1979)

The rossette inhibition test, an established test for determining the immunosuppressive potential of antilymphocyte serum, has been applied to the serum of sheep after mating. The rosette inhibition titre was much higher (12--26) in 7 sheep which were fertilized and remained pregnant for up to 21 days than in 5 sterile ewes mated with intact rams (8--10). The difference was apparent by 24 h after mating. One ewe had high titres for 6 days after mating but these then dropped and she returned to oestrus; early embryonic loss was suspected. Another ewe which returned to oestrus had consistently low titres. The results indicate that the rosette inhibition test can be used to detect fertilization, early embryonic death and continued pregnancy in sheep.
Research on QoS Multicast Routing Optimization Algorithm Based on Hybrid Genetic Algorithm (2008)

Based on QoS constraints such as delay, delay jitter, bandwidth and packet loss metrics this paper describes a network model suitable for investigating the routing problem and presents a multicast routing algorithm with multiple QoS constraints based on GA and TS hybrid strategy. This algorithm takes advantage of GA and TS and overcomes the shortcomings of GA used in solving the multicast routing problem with multiple QoS constraints-poor climbing ability and immature convergence. Simulation results show that the algorithm is an effective approach to the problem of multicast routing decision with multiple QoS constraints.
Parallel Oblivious Array Access for Secure Multiparty Computation and Privacy-Preserving Minimum Spanning Trees (2015)

Abstract In this paper, we describe efficient protocols to perform in parallel many reads and writes in private arrays according to private indices. The protocol is implemented on top of the Arithmetic Black Box (ABB) and can be freely composed to build larger privacypreserving applications. For a large class of secure multiparty computation (SMC) protocols, our technique has better practical and asymptotic performance than any previous ORAM technique that has been adapted for use in SMC. Our ORAM technique opens up a large class of parallel algorithms for adoption to run on SMC platforms. In this paper, we demonstrate how the minimum spanning tree (MST) finding algorithm by Awerbuch and Shiloach can be executed without revealing any details about the underlying graph (beside its size). The data accesses of this algorithm heavily depend on the location and weight of edges (which are private) and our ORAM technique is instrumental in their execution. Our implementation is the first-ever realization of a privacypreserving MST algorithm with sublinear round complexity.
Microstructural Observations of Fusion Welded Boron-Aluminum Composites (1972)

Welding studies were conducted on boron-aluminum (B/Al) composites to observe the effects of gas-tungsten arc fusion welding on the boron reinforcing filaments and aluminum matrix. The objective of this investigation was to determine the basic potential of fusion welding B/Al composites for possible structural applications. Microstructural observations after welding revealed matrix fusion without apparent boron filament damage. Analysis of weld metal regions indicated that aluminum filler metal additions intermixed with the matrix and altered its chemical composition. It is concluded that fusion welding of B/Al composites may be possible by control of welding energy input.
The single transmembrane segment of gp210 is sufficient for sorting to the pore membrane domain of the nuclear envelope. (1992)

The glycoprotein gp210 is located in the "pore membrane," a specialized domain of the nuclear envelope to which the nuclear pore complex (NPC) is anchored. gp210 contains a large cisternal domain, a single transmembrane segment (TM), and a COOH-terminal, 58-amino acid residue cytoplasmic tail (CT) (Wozniak, R. W., E. Bartnik, and G. Blobel. 1989. J. Cell Biol. 108:2083-2092; Greber, U. F., A. Senior, and L. Gerace. 1990. EMBO (Eur. Mol. Biol. Organ.) J. 9:1495-1502). To locate determinants for sorting of gp210 to the pore membrane, we constructed various cDNAs coding for wild-type, mutant, and chimeric gp210, and monitored localization of the expressed protein in 3T3 cells by immunofluorescence microscopy using appropriate antibodies. The large cisternal domain of gp210 (95% of its mass) did not reveal any sorting determinants. Surprisingly, the TM of gp210 is sufficient for sorting to the pore membrane. The CT also contains a sorting determinant, but it is weaker than that of the TM. We propose specific lateral association of the transmembrane helices of two proteins to yield either a gp210 homodimer or a heterodimer of gp210 and another protein. The cytoplasmically oriented tails of these dimers may bind cooperatively to the adjacent NPCs. In addition, we demonstrate that gp210 co-localizes with cytoplasmically dispersed nucleoporins, suggesting a cytoplasmic association of these components.
Structural quality of parts processed by fused deposition (1996)

Abstract Commercial solid freeform fabrication (SFF) systems, which have been developed for fabrication of wax and polymer parts for form and fit and secondary applications, such as moulds for casting, etc., require further improvements for use in direct processing of structural ceramic and metal parts. Defects, both surface as well as internal, are undesirable in SFF processed ceramic and metal parts for structural and functional applications. Process improvements are needed before any SFF technique can successfully be commercialized for structural ceramic and metal processing. Describes process improvements made in new SFF techniques, called fused deposition of ceramics (FDC) and metals (FDMet), for fabrication of structural and functional ceramic and metal parts. They are based on an existing SFF technique, fused deposition modelling (FDM) and use commercial FDM systems. The current state of SFF technology and commercial FDM systems results in parts with several surface and internal defects which, if not eliminated, severely limit the structural properties of ceramic and metal parts thus produced. Describes systematically, in detail, the nature of these defects and their origins. Discusses several novel strategies for elimination of most of these defects. Shows how some of these strategies have successfully been implemented to result in ceramic parts with structural properties comparable to those obtained in conventionally processed ceramics.
Optimal design of virtual networks for resilient cloud services (2013)

Currently, accessing global cloud services has its limitations in end-to-end quality of experience (QoE) due to the independent operation of cloud infrastructures and communication networks. The novel virtual network design approaches for resilient cloud services that are presented in this paper can realize end-to-end availability and latency guarantees by combining the control of network and cloud resources. We formulate design models as linear optimization problems to realize resilience either at the virtual or the physical layer. On the basis of extensive simulations, we analyze the effect on the overall performance when cost factors and influential parameters of the network virtualization environment are varied. We compare the proposed models in detail and show that they outperform prior approaches. Finally, we provide a discussion about the implementation and applicability of the proposed models.
How Spike Generation Mechanisms Determine the Neuronal Response to Fluctuating Inputs (2003)

This study examines the ability of neurons to track temporally varying inputs, namely by investigating how the instantaneous firing rate of a neuron is modulated by a noisy input with a small sinusoidal component with frequency (f). Using numerical simulations of conductance-based neurons and analytical calculations of one-variable nonlinear integrate-and-fire neurons, we characterized the dependence of this modulation on f. For sufficiently high noise, the neuron acts as a low-pass filter. The modulation amplitude is approximately constant for frequencies up to a cutoff frequency, fc, after which it decays. The cutoff frequency increases almost linearly with the firing rate. For higher frequencies, the modulation amplitude decays as C/falpha, where the power alpha depends on the spike initiation mechanism. For conductance-based models, alpha = 1, and the prefactor C depends solely on the average firing rate and a spike "slope factor," which determines the sharpness of the spike initiation. These results are attributable to the fact that near threshold, the sodium activation variable can be approximated by an exponential function. Using this feature, we propose a simplified one-variable model, the "exponential integrate-and-fire neuron," as an approximation of a conductance-based model. We show that this model reproduces the dynamics of a simple conductance-based model extremely well. Our study shows how an intrinsic neuronal property (the characteristics of fast sodium channels) determines the speed with which neurons can track changes in input.
Speech Emotion Classification Using Machine Learning Algorithms (2008)

The recognition of emotional states is a relatively new technique in the field of machine learning. The paper presents the study and the performance results of a system for emotion classification using the architecture of a distributed speech recognition system (DSR). The features used were extracted by the front-end ETSI Aurora eXtended of a mobile terminal in compliance with the ETSI ES 202-211 V1.1.1 standard. On the basis of the time trend of these parameters, over 3800 statistical parameters were extracted to characterize semantic units of varying length (sentences and words). Using the WEKA (Waikato Environment for Knowledge Analysis) software the most significant parameters for the classification of emotional states were selected and the results of various classification techniques were analysed. The results, obtained using both the Berlin Database of Emotional Speech (EMO-DB) and the Speech Under Simulated and Actual Stress (SUSAS) corpus, showed that the best performance is achieved using a support vector machine (SVM) trained with the sequential minimal optimization (SMO) algorithm, after normalizing and discretizing the input statistical parameters.
The identification and purification of a mammalian- like protein kinase C in the yeast <i>Saccharomyces cerevisiae</i> (1991)

We have purified a yeast protein kinase that is phospholipid-dependent and activated by Diacylglycerol (DAG) in the presence of Ca2+ or by the tumour-promoting agent tetradecanoyl-phorbol acetate (TPA). The properties of this enzyme are similar to those of the mammalian protein kinase C (PKC). The enzyme was purified using chromatography on DEAE-cellulose followed by hydroxylapatite. The latter chromatography separated the activity to three distinguishable sub-species, analogous to the mammalian PKC isoenzymes. The fractions enriched in PKC activity contain proteins that specifically bind TPA, are specifically phosphorylated in the presence of DAG and recognized by anti-mammalian PKC antibodies.
Standby power management for a 0.18/spl mu/m microprocessor (2002)

Static power dissipation is a concern for battery powered hand-held devices since it can substantially impact the battery life. Here, the use of reverse body bias to limit IM on the high performance, low power XScale™ microprocessor core is described. The scheme utilized is amenable to implementation on a low-cost (non-triple well) process and has limited regulation requirements. The regulation requirements and circuits are described, as is the performance of the method. A measured current reduction factor of over 25 is achieved with this method of reverse body bias. Implications of the use of body bias leakage control for active power and performance, as well as system level implications are also discussed.
Integration of vertical-cavity surface-emitting devices by molecular beam epitaxy regrowth (1994)

We used two-step molecular beam epitaxial (MBE) growth to integrate monolithically single and double vertical-cavity structures on a wafer. This technique is useful for making a single vertical-cavity surface-emitting laser–thyristor with a low threshold and a double vertical-cavity heterojunction phototransistor with both a high responsivity and a large spectral bandwidth. Regrowth on a patterned distributed Bragg reflector after thermal desorption of a passivating GaAs layer resulted in the laser in the single-cavity section having a threshold current density of 1.0 kA/cm2, which is comparable to that of one grown by conventional one-step MBE. Controlling thickness to within ±0.3% resulted in the regrown double-cavity section having a bandwidth of 5 nm.
[Main virulence factors in Escherichia coli isolates from swine over two weeks old with edema disease and/or E. coli diarrhea]. (2000)

The OK antigens and the fimbriae F4 of E. coli with haemolysis isolated from 113 cases of oedema disease and/or diarrhoea were identified serologically. The genes for F18 and for enterotoxins LT, STIa and STII as well as Shigatoxin Stx2e were determined by PCR. Fimbrial variants F18ab and F18ac were distinguished by means of indirect immunofluorescence on smears prepared from the intestinal mucosa and from cultures grown under appropriate conditions. Adhesive fimbriae were detected with every case or isolate, respectively, by means of at least one out of the techniques mentioned above. The serogroup O149:K91 with fimbriae F4ac (K88ac) and genes for the enterotoxins LT and STII was most prevalent. Serogroup O139:K12 with fimbriae F18ab and the gene for Stx2e was second, whereas serogroups O141ab and O141ac with fimbriae F18ac and genes for Stx2e, STII and often LT were much less prevalent. The serogroup O147:K89 with fimbriae F18ac, and genes for STIa and STII was detected for the first time in Switzerland.
Discovery and Optimization of Piperidyl-1,2,3-Triazole Ureas as Potent, Selective, and in Vivo-Active Inhibitors of α/β-Hydrolase Domain Containing 6 (ABHD6) (2013)

α/β-Hydrolase domain containing 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes the endogenous cannabinoid 2-arachidonoylglycerol (2-AG) to regulate certain forms of cannabinoid receptor-dependent signaling in the nervous system. The full spectrum of ABHD6 metabolic activities and functions is currently unknown and would benefit from selective, in vivo-active inhibitors. Here, we report the development and characterization of an advanced series of irreversible (2-substituted)-piperidyl-1,2,3-triazole urea inhibitors of ABHD6, including compounds KT182 and KT203, which show exceptional potency and selectivity in cells (<5 nM) and, at equivalent doses in mice (1 mg kg(-1)), act as systemic and peripherally restricted ABHD6 inhibitors, respectively. We also describe an orally bioavailable ABHD6 inhibitor, KT185, that displays excellent selectivity against other brain and liver serine hydrolases in vivo. We thus describe several chemical probes for biological studies of ABHD6, including brain-penetrant and peripherally restricted inhibitors that should prove of value for interrogating ABHD6 function in animal models.
Siltuximab: A new option for the management of Castleman's disease (2015)

Castleman's disease is a rare lymphoproliferative disorder the underlying mechanism of which remains unclear. However, interleukin-6 (IL-6) may play a role in the pathogenesis of the disease. Blockade of the IL-6 pathway has been explored in multiple preclinical and clinical studies with promising results for the treatment of different types of cancer and Castleman's disease. Siltuximab is a human/murine chimeric immunoglobulin G1kappa (IgG1kappa) monoclonal antibody against human IL-6. It binds to IL-6 neutralizing its biological activity. Recent phase II clinical studies in patients with multicentric Castleman's disease have shown the efficacy and safety of siltuximab in patients with this condition. Results from this study led to the recent approval of siltuximab for the treatment of Castleman's disease by the FDA and EMA.
Information Triage with TRIST (2005)

TRIST (“The Rapid Information Scanning Tool”) is the information retrieval and triage component for the analytical environment called nSpace. TRIST uses Human Information Interaction (HII) techniques to interact with massive data in order to quickly uncover the relevant, novel and unexpected. TRIST provides query planning, rapid scanning over thousands of search results in one display, and includes multiple linked dimensions for result characterization and correlation. It also forms a cohesive platform for integrating computational linguistic capabilities such as entity extraction, document clustering and other new techniques. Analysts work with TRIST to triage their massive data and to extract information into the Sandbox evidence marshalling environment. Initial experiments with TRIST show that analyst work product quality is increased, in half the time, while reading double the documents.
ASTEROID-IMPACT HYPOTHESIS OF TEKTITE ORIGIN III. THE SOUTHEAST ASIAN STREWN FIELDS (1963)

Geographical distribution in southeast asian strewn field of tektites used to prove asteroid impact hypothesis of tektite origin
Angle- and size-dependent characteristics of incoherent Raman and fluorescent scattering by microspheres 2 Numerical Simulation (2002)

The results of numerical simulation of inelastic scattering by microspheres with the use of a dipole model are presented. The formulas that are derived speed up the computation, thereby permitting larger-sized microspheres to be studied. The angular scattering cross section and depolarization are calculated for a wide range of size parameters as well as for different orientations of incident wave polarization. Calculations performed with small incremental changes in size permit the influence of morphology-dependent resonance (MDR) on the power and angular distribution of scattered radiation to be studied. TM and TE types of MDR produce enhanced scattering of the incident wave with vertical and horizontal polarization; the corresponding shape of the phase function becomes oscillatory. Special attention is paid to the simulation of backward scattering by water droplets, which is important for Raman lidar applications.