gebhart/patrepeval huggingface dataset:
Intelligent agent-based scheduling mechanism for grid service (2005)

Load balancing and fault tolerance are two key concerns when developing distributed computing applications. The emergence of grid computing environments extends this problem. Based on distributed scheduling architecture, a grid service oriented scheduling model is proposed to enable load balancing in this paper. In this model, the functionalities are characterized by fault tolerance, and implemented by applying intelligent agent technology. Degree of credit is introduced to make that a decision of grid service selection, service instance selection/migration and service instance redundancy, context agents are responsible for sensing the context of grid, and balance agents are enforced to automatically serve the scheduler for dynamic load adjustment and service-level fault tolerance. Between agents, information exchange is conducted via an agent communication language.
Trace Elements in Hair, as Related to Exposure in Metropolitan New York (1975)

Previous studies have revealed that trace element concentrations in hair can reflect exposure in cases of frank poisoning and deficiency. This study reports significant correlations within a single metropolitan area between trace-element content of hair and exposure (as measured by analyses for the corresponding elements in dustfall or housedust) for Ba, Cr, Pb, Hg, Ni, Sn, and V. Age, sex, hair color, and smoking habits were factors included in the statistical evaluation. Several metals increase and decrease together in the hair specimens, in agreement with trends reported for other human tissues.
Relationships between hoof-acceleration patterns of galloping horses and dynamic properties of the track (2005)

The inverse relationship between track rebound rate and negative acceleration peaks for all hooves reflects the most important dynamic property of a track. Any factor that reduces negative acceleration of the hooves will increase stride efficiency by allowing smoother transition from retardation to propulsion and therefore may be important in determining the safety of racing surfaces.
Dynamics of naturally acquired antibody against Haemophilus influenzae type a capsular polysaccharide in a Canadian Aboriginal population (2016)

Severe infections caused by Haemophilus influenzae type a (Hia) have reached alarming rates in some Canadian Aboriginal communities. We sought to estimate the frequency of exposure to this pathogen and timelines for boosting protective antibodies. We developed a model of secondary antigenic challenge (natural exposure), and used data for anti-Hia antibodies in serum samples of healthy and immunocompromised adults in a population of Northwestern Ontario, Canada. We parameterized the model with available estimates from previous studies for the decay rate of antibody and its protective levels against both Hia carriage and invasive disease. Simulations were initialized using antibody concentrations from data. We investigated both the duration of immunity without secondary antigenic challenge and the average time between subsequent exposures to Hia. When there was no new natural exposure, serum antibody concentrations in healthy Aboriginal individuals decreased below the level (1 μg/ml) assumed for protection against invasive Hia disease 3 years after primary exposure. This period was shorter (about 2 years) for Aboriginal individuals suffering from chronic renal failure. We estimated that a new antigenic challenge occurs once in 5 and 2 years for healthy and immunocompromised Aboriginal individuals, respectively. More frequent natural exposure was required to maintain protective antibody levels for non-Aboriginal individuals compared to Aboriginal individuals. The findings suggest that frequent boosting of natural immunity is required to maintain the anti-Hia antibody levels protecting against invasive Hia disease, particularly in individuals with underlying medical conditions. This information has important implications for immunization when an anti-Hia vaccine becomes available.
Implementation of Rate Matching with Low Latency and Little Memory for LTE Turbo Code (2013)

In LTE (Long Term Evolution), the high utilization for physical resources is achieved by scheduling suitable number of time frequency resource elements for one user in one subframe. This is supported by the rate matching module that selecting arbitrary number of bits from the turbo coding bit streams. In this paper, a closed-form rate matching implementation method is proposed. It derives an integrated expression which is normalized for the 3 turbo coding streams. This expression sets up a mapping relationship between the bit streams input to and the bit sequence output from rate matching module. Moreover, the expression can be applied to rate de-matching processing in the receiver end. Compared with the existing method, the rate matching method that we proposed generates low latency and requires small memory.
Modeling the personalized variations in liver disease due to α1-antitrypsin deficiency using induced pluripotent stem cell-derived hepatocyte-like cells (2015)

In the classical form of α1-antitrypsin deficiency (ATD), aberrant intracellular accumulation of misfolded mutant α1-antitrypsin Z (ATZ) in hepatocytes causes hepatic damage by a gain-of-function, “proteotoxic” mechanism. Whereas some ATD patients develop severe liver disease that necessitates liver transplantation, others with the same genetic defect completely escape this clinical phenotype. We investigated whether induced pluripotent stem cells (iPSCs) from ATD individuals with or without severe liver disease could model these personalized variations in hepatic disease phenotypes. Patient-specific iPSCs were generated from ATD patients and a control, and differentiated into hepatocyte-like cells (iHeps) having many characteristics of hepatocytes. Pulse-chase and endoglycosidase H analysis demonstrate that the iHeps recapitulate the abnormal accumulation and processing of the ATZ molecule, compared to the wild-type AT molecule. Measurements of the fate of intracellular ATZ show a marked delay in the rate of ATZ degradation in iHeps from severe liver disease patients, compared to those from no liver disease patients. Transmission electron microscopy showed dilated rough endoplasmic reticulum in iHeps from all individuals with ATD, not in controls, but globular inclusions that are partially covered with ribosomes were observed only in iHeps from individuals with severe liver disease. These results provide definitive validation that iHeps model the individual disease phenotypes of ATD patients with more rapid degradation of misfolded ATZ and lack of globular inclusions in cells from patients who have escaped liver disease. The results support the concept that “proteostasis” mechanisms, such as intracellular degradation pathways, play a role in observed variations in clinical phenotype and show that iPSCs can potentially be used to facilitate predictions of disease susceptibility for more precise and timely application of therapeutic strategies.
Selective Inhibition of Fatty Acid Synthase for Lung Cancer Treatment (2007)

We conclude that inhibition of FAS can be achieved without parallel stimulation of fatty acid oxidation and that inhibition of tumor growth in vivo can be achieved without anorexia and weight loss. Thus, this therapeutic strategy holds promise for clinical treatment of cancers, including non-small cell lung cancer, the leading cause of cancer mortality in the United States and Europe.
A Scalable Framework for High-Resolution Immersive Displays (2002)

We introduce an immersive display framework that is scalable, easily re-configurable, and does not constrain the display surface geometry. The system achieves very-high resolution display through synchronized rendering and display from multiple PCs and light projectors. The projectors can be placed in a loose configuration and calibrated at run time. A full display is composed of these underlying display devices by blending overlapping regions and pre-warping imagery to correct for distortions due to display surface shape and the viewer's position. The effect is a perceptually correct display of a single high-resolution frame buffer.A major contribution of the work is the addition of cameras into the display environment that assist in calibration of projector positions and the automatic recovery of the display surface shape. In addition, a straightforward synchronization framework is introduced that facilitates communication between the multiple rendering elements for calibration, tracking the user's viewing position, and synchronous endering of a uniform, perceptually correct image.
Recent Advances in Bioprinting and Applications for Biosensing (2014)

Future biosensing applications will require high performance, including real-time monitoring of physiological events, incorporation of biosensors into feedback-based devices, detection of toxins, and advanced diagnostics. Such functionality will necessitate biosensors with increased sensitivity, specificity, and throughput, as well as the ability to simultaneously detect multiple analytes. While these demands have yet to be fully realized, recent advances in biofabrication may allow sensors to achieve the high spatial sensitivity required, and bring us closer to achieving devices with these capabilities. To this end, we review recent advances in biofabrication techniques that may enable cutting-edge biosensors. In particular, we focus on bioprinting techniques (e.g., microcontact printing, inkjet printing, and laser direct-write) that may prove pivotal to biosensor fabrication and scaling. Recent biosensors have employed these fabrication techniques with success, and further development may enable higher performance, including multiplexing multiple analytes or cell types within a single biosensor. We also review recent advances in 3D bioprinting, and explore their potential to create biosensors with live cells encapsulated in 3D microenvironments. Such advances in biofabrication will expand biosensor utility and availability, with impact realized in many interdisciplinary fields, as well as in the clinic.
Cytologic features of prostatic adenocarcinoma in urine: A clinicopathologic and immunocytochemical study (1988)

Cells of adenocarcinoma of the prostate (ACP) are infrequently shed in urine. We examined the clinicopathologic features of 22 patients with ACP and tumor cells in urine. Patients typically were clinical stage C or D and had hematuria (13 cases, 59%) and/or obstruction (11 cases, 50%). Prostatic palpation or instrumentation preceded collection of 15 urine specimens. Histologically, tumors were high grade (Gleason score 7-10) and extensive, with involvement of prostatic ducts and acini (10 cases, 45%) and prostatic urethra (5 cases, 23%). Cytologically, the background was clean, and neoplastic cells appeared singly, in loose clusters, as large "casts," or, rarely, in papillary structures. The cells were small, round to oval, with a moderate amount of finely granular or vacuolated cytoplasm; nuclei were generally round with a thin, often irregular membrane, finely granular chromatin, and a single prominent nucleolus. Immunoperoxidase staining for prostatic acid phosphatase and prostate-specific antigen was useful in distinguishing ACP from transitional cell carcinoma.
Melatonin Replacement Therapy of Elderly Insomniacs (1995)

Changes in sleep-wake patterns are among the hallmarks of biological aging. Previously, we reported that impaired melatonin secretion is associated with sleep disorders in old age. In this study we investigated the effects of melatonin replacement therapy on melatonin-deficient elderly insomniacs. The study comprised a running-in, no-treatment period and four experimental periods. During the second, third and fourth periods, subjects were administered tablets for 7 consecutive days, 2 hours before desired bedtime. The tablets were either 2 mg melatonin administered as sustained-release or fast-release formulations, or an identical-looking placebo. The fifth period, which concluded the study, was a 2-month period of daily administration of 1 mg sustained-release melatonin 2 hours before desired bedtime. During each of these five experimental periods, sleep-wake patterns were monitored by wrist-worn actigraphs. Analysis of the first three 1-week periods revealed that a 1-week treatment with 2 mg sustained-release melatonin was effective for sleep maintenance (i.e. sleep efficiency and activity level) of elderly insomniacs, while sleep initiation was improved by the fast-release melatonin treatment. Sleep maintenance and initiation were further improved following the 2-month 1-mg sustained-release melatonin treatment, indicating that tolerance had not developed. After cessation of treatment, sleep quality deteriorated. Our findings suggest that for melatonin-deficient elderly insomniacs, melatonin replacement therapy may be beneficial in the initiation and maintenance of sleep.
Patents for Chemical Inventions, Copyright, Advances in Chemistry Series, FOREWORD (1964)

ADVERTISEMENT RETURN TO BOOKFront MatterNEXTPatents for Chemical Inventions, Copyright, Advances in Chemistry Series, FOREWORDRobert F. GouldRobert F. GouldMore by Robert F. GouldDOI: 10.1021/ba-1964-0046.fw001Publication Date (Print):January 1, 1964Publication History Published online22 July 2009Published inprint 1 January 1964RIGHTS & PERMISSIONSPatents for Chemical Inventionspp i-ivAdvances in ChemistryVol. 46ISBN13: 9780841200470eISBN: 9780841222267 Copyright © 1964 AMERICAN CHEMICAL SOCIETYChapter Views315Citations1LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (199 KB) Get e-Alerts
CYCLOSPORINE-INDUCED PSEUDO-GRAFT-VERSUS-HOST DISEASE IN THE EARLY POST-CYCLOSPORINE PERIOD1 (1988)

Cyclosporine-induced pseudo-graft-versus-host disease (CIPGVHD) in syngeneic or autologous rat marrow chimeras has clinical and histologic features closely resembling classic graft-versus-host disease in the allogeneic chimera. We describe here the pathology and immunopathology of the usual target tissues in CIPGVHD developing in the first week following CsA (early group). The findings are constrasted to the CIPGVHD developing during the second week post-CsA (later group). Six of 9 rats in the early group had acute-type CIPGVHD in the tongue, skin, liver, intestines, and mainstem bronchi. In general, the lymphocytic infiltrates in these tissues were in intimate contact with injured epithelial cells. The intestines had multiple apoptotic lesions. Class II antigen was prominent in the tongue mucosa, but only patchy expression was evident in 2 skin biopsies. All of the lymphocytes infiltrating the mucosa were CD8+(OX-8)/CD4-(W3/25) T cells (OX-19+). Most of the lymphocytes in the lamina propria expressed CD4 as well as CD8 markers, suggesting coexpression. In the later group, 6 of 7 rats had chronic-type CIPGVHD (1 with acute and chronic) while 1 rat had no GVHD (P = .02, Fisher's exact test compared with the early group). These animals had features characteristic of established chronic GVHD in the skin, tongue, liver, intestines, and salivary glands. Fibrosis of the dermis and lamina propria was prominent in the skin and tongue. Submucosal fibrosis was increased in the small intestine. The salivary glands had an interstitial infiltrate and fibrosis with loss of ducts and glands. Class II antigen was prominent in the epidermis of the tongue and skin of all rats. The number of lymphocytes infiltrating the mucosa of the tongue was considerably smaller than seen in the early group. More than 90% of these cells were T cells, as detected by OX-19, and expressed both CD4 and CD8 markers. While most lamina propria lymphocytes expressed the CD4 antigen, there were significantly fewer CD8+ cells, consistent with increased numbers of CD8-/CD4+ helper-phenotype cells. The observations indicate that immediately post-CsA, the CIPGVHD is primarily acute, with epithelial infiltrates of CD8+/CD4- T cells and lamina propria infiltrates that include double-labeled cells consistent with immature thymocytes. There is a rapid transition to established chronic-type CIPGVHD by the second week. The residual mucosal infiltrate is now dominated by double-labeled T cells or thymocytes while the lamina propria infiltrate has more mature helper-phenotype T cells. Induced RT1.B/D antigen could be important in the pathogenesis of the peripheral tissue manifestations.
Release of biologically active TGF-β1 by alveolar epithelial cells results in pulmonary fibrosis (2003)

Idiopathic pulmonary fibrosis (IPF) is a progressive fatal fibrotic lung disease. Transforming growth factor (TGF)-beta1 is present in a biologically active conformation in the epithelial cells lining lesions with advanced IPF. To determine the role of aberrant expression of biologically active TGF-beta1 by alveolar epithelial cells (AECs), the AECs of explanted normal rat lungs were transfected with the TGF-beta1 gene using the retrovirus pMX-L-s223,225-TGF-beta1. In situ hybridization using a digoxigenin-labeled cDNA of the puromycin resistance gene contained in the pMX demonstrated that pMX-L-s233,225-TGF-beta1 was selectively transfected into AECs of the explants. Conditioned media overlying explants obtained 7 days after being treated with pMX-L-s223,225-TGF-beta1 contained 14.5 +/- 3.15 pg/ml of active TGF-beta1. With the use of Masson's trichrome staining of explant sections obtained 14 days after transfection, there were lesions similar to those in IPF, characterized by type II AEC hyperplasia, interstitial thickening, extensive increase in interstitial and subepithelial collagen, an increase in the number of fibroblasts, and areas resembling fibroblast buds. Collagens I, III, IV, and V and fibronectin were increased in explants treated with pMX-L-s223,225-TGF-beta1. The findings in the current study suggest that IPF may be a disorder of epithelial cells and not inflammatory cells.
Preparation of 2,5-Bis(Aminomethyl)Furan by Direct Reductive Amination of 2,5-Diformylfuran over Nickel-Raney Catalysts (2015)

The direct reductive amination of 2,5-diformylfuran (DFF) with ammonia to 2,5-bis(aminomethyl)furan (BAF) was demonstrated, for the first time, over the commercial type Nickel-Raney and acid treated Nickel-Raney catalysts. The effects of reaction parameters such as reaction medium, temperature and hydrogen pressure were described. The acid treated Nickel-Raney catalyst exhibited the highest BAF yield in the THF-water mixed reaction medium. The relatively higher Ni0 species composition and larger surface area of the acid treated Nickel-Raney catalyst with specific reaction conditions contributed greatly to the BAF formation. The oligomeric species, such as furanic imine trimers and tetramers confirmed by MALDI-MS analysis were presented as the intermediates of DFF reductive amination.
Low-threshold CW submillimeter- and millimeter-wave laser action in CO<sub>2</sub>-1aser-pumped C<sub>2</sub>H<sub>2</sub>F<sub>2</sub>, and CH<sub>3</sub>OH (1973)

Abstract : CW laser action between 40.7 micrometers and 1.02 mm is described in 1, 1 difluoroethane, 1, 1 difluoroethylene, and methyl alcohol optically pumped by a CO2 laser. Far infrared radiation (FIR) laser threshold was achieved for CO2 pump powers of typically 1 to 2 watts, and FIR laser output powers of several milliwatts were observed on the stronger lines. (Modified author abstract)
William Kronig, New Mexico Pioneer (concl.) (1944)

CHAPTER VIII 'T .HE TOWN of Rio Colorado was built on high .ground. . . .A large valley extended to the east, where were 'mead~ ows and farm lands~.Opposite the town, where the valley widens out to the west, the river came out of a deep canyon;' .' at this point is where the La Port farm was located.La Port had resided there for many years with his family, including his two sons and son-in-law. 39 They managed their ranch as well as performed the major.part of the farm labor.However, they occasionally hired a few men to help do the harvesting and do other heavy farm work.' ' These four men were, at all times, armed with their Hawkins rifles; even when they irrigated the fields they carried . '. .their weapons and also, a good supply of ammunition~ In this community it was necessary for everyone-to be able to muster a rifle or handle bows and arrows. On this day, all the men gathered at the edge of the hill where the town herd was grazing.The Indians were already on the hilltops ; the horses and mules .belonging to the community were moving toward the' Cl:Lnyon, where the La Ports opened fire,.wounding two Indians at their first volley~ The Leaders dismoui:J.ted,picked up their two .wounded men and .carriedthem off, leaving the horses and mules' they were driVing., one of the Indians, more daring than the rest, was completely cut off by .the .town people and surrounded.I took a careful aim at him and was in the act of pulling the trigger, when someone pushed my gun up and the ball went into the air."For God's sake, don't kill him; he is the son of the rich Juan Vigil." 40I ' ' could not see 'that that fact made any difference,.as he was, 39.No data on the La Port family have been found elsewhere.40.This "Juan Vigil" has not been identified. 271. ' ... ' ' ' . .
MPC-Based Building Climate Controller Incorporating Humidity (2019)

Although Model Predictive Control (MPC) has been widely investigated for energy efficient climate control of buildings, most prior works have neglected humidity in the problem formulation and performance evaluations. A climate control algorithm that ignores humidity cannot be used in practice, especially in hot-humid climates. Apart from the discomfort of occupants, high humidity over long periods will lead to issues such as mold growth, adversely impacting occupant health. In this paper, we provide an MPC formulation that explicitly accounts for humidity constraints in a principled manner. We show how to construct data-driven low order models of a cooling and dehumidifying coil that can be used in the MPC formulation. The resulting controller's performance is tested in simulation using a plant that differs significantly from the model used by the optimizer. In spite of the large plant model mismatch, the proposed MPC controller performs well. Humidity constraints are seen to be active for a large part of the day, especially in the summer. MPC formulations that ignore humidity would lead to a poor indoor climate in these situations.
Development of smart shopping carts with customer-oriented service (2016)

This paper presents a preliminary development of the smart shopping cart (SSC) that can be integrated into the smart mall system. The SSC can provide customers with the efficient user interface so that the shopping service can be effectively promoted. In the current design, with the function of face recognition on the user interface, the SSC can recognize the customer and further provide the associated assistive shopping information based on the purchase history. With the use of radio-frequency identification (RFID) tags, the SSC can automatically detect the various products which are being added in the cart and show the related information on the user interface. Through the searching function of SSC, the purchasing efficiency and navigation aid in the mall can be effectively supplied. Finally, the automatic billing service can be done by the SSC and the stored shopping data will be transmitted to the cloud server of shopping mall. The experimental demonstration shows the effectiveness of the proposed SSC which interacts with the customer and provides efficient shopping service.