gebhart/patrepeval huggingface dataset:
Polymer-Nanoparticle Composites: From Synthesis to Modern Applications (2010)

The addition of inorganic spherical nanoparticles to polymers allows the modification of the polymers physical properties as well as the implementation of new features in the polymer matrix. This review article covers considerations on special features of inorganic nanoparticles, the most important synthesis methods for ceramic nanoparticles and nanocomposites, nanoparticle surface modification, and composite formation, including drawbacks. Classical nanocomposite properties, as thermomechanical, dielectric, conductive, magnetic, as well as optical properties, will be summarized. Finally, typical existing and potential applications will be shown with the focus on new and innovative applications, like in energy storage systems.
Postoperative hypothermia—The chilling consequences (2006)

Unplanned hypothermia is commonly encountered in the perioperative period. Nursing has contributed to the literature on hypothermia with studies on shivering and treatment modalities; however, the direct physiological consequences of postoperative hypothermia have been reported mainly in the medical literature. Research on the physiological effects of postoperative hypothermia offers nurses further evidence to support interventions for temperature correction in patients with hypothermia. Evidence indicates that forced-air warming is the most effective method for warming hypothermic patients. The Roy Adaptation Model is explained as a framework for nursing care of patients with hypothermia. Clinical practice guidelines for unplanned perioperative hypothermia also are provided.
RF Passive Components Using Metal Line on Si CMOS (2006)

This paper discusses the design and performance of on-chip passive components of transmission lines (TR) and inductors. First, the measurement technique of on chip passives is discussed. A transmission line that can be used for Gbps signal propagation on Si CMOS is examined. As a high density transmission line structure of diagonal-pair differential TR line is described. Also, a circuit and TR line is introduced for above 10 Gbps signal propagation. The on-chip inductor which is a key passive component in RF application of Si CMOS technology is discussed. We examine some on-chip inductors that have been developed in our group: small area inductor, high performance inductor using WL-CSP (Wafer-Level Chip-Size-Packaging) technology. Finally, a wide tuning range LC-VCO using a variable inductor for RF reconfigurable circuit is introduced.
Evolution of Phase-Change Memory for the Storage-Class Memory and Beyond (2020)

In this article, the development history and the technical hurdles of phase-change memory (PCM) are reviewed and recent progress and future directions are discussed. Prospects of PCM for storage-class memory (SCM) are discussed in terms of the technical challenges to satisfy the market requirements, mainly for the performance and cost effectiveness. For a more in-depth discussion, PCM is segmented into the memory part, the access device part, and the sensing scheme part. In the memory part, Set (crystallization)-Reset (amorphization) write characteristics and thermal disturbance (TDB) will be reinterpreted in terms of power consumption and performance of SCM. In the access device part, the application history of various devices, such as the transistor, the diode, and the two-terminal selector, will be reviewed and explained based on the process integration issues and area efficiency. In the next part, various sensing schemes used to make a lower read latency, multilevel cell (MLC), and cross point (X-point) are summarized. Thereafter, future directions and possible evolution pathways of 3-D structures, including X-point and vertical X-point (VXP), will be discussed for the first time. Finally, the feasibility of PCM for neuromorphic application will be followed.
Carbohydrate specificity of sea urchin sperm bindin: a cell surface lectin mediating sperm-egg adhesion. (1982)

We have examined the carbohydrate specificity of bindin, a sperm protein responsible for the adhesion of sea urchin sperm to eggs, by investigating the interaction of a number of polysaccharides and glycoconjugates with isolated bindin. Several of these polysaccharides inhibit the agglutination of eggs by bindin particles. An egg surface polysaccharide was found to be the most potent inhibitor of bindin-mediated egg agglutination. Fucoidin, a sulfated fucose heteropolysaccharide, was the next most potent inhibitor, followed by the egg jelly fucan, a sulfated fucose homopolysaccharide, and xylan, a beta(1 leads to 4) linked xylose polysaccharide. A wide variety of other polysaccharides and glycoconjugates were found to have no effect on egg agglutination. We also report that isolated bindin has a soluble lectinlike activity which is assayed by agglutination of erythrocytes. The bindin lectin activity is inhibited by the same polysaccharides that inhibit egg agglutination by particulate bindin. This suggests that the egg adhesion activity of bindin is directly related to its lectin activity. We have established that fucoidin binds specifically to bindin particles with a high apparent affinity (Kd = 5.5 X 10(-8) M). The other polysaccharides that inhibit egg agglutination also inhibit the binding of 125I-fucoidin to bindin particles, suggesting that they compete for the same site on bindin. The observation that polysaccharides of different composition and linkage type interact with bindin suggests that the critical structural features required for binding may reside at a higher level of organization. Together, these findings strengthen the hypothesis that sperm-egg adhesion in sea urchins is mediated by a lectin-polysaccharide type of interaction.
Treatment of Myasthenia Gravis (1973)

THE therapy of myasthenia gravis is one of the more challenging but often also one of the most rewarding forms of drug therapy encountered by the physician. Myasthenia is a chronic disease characterized by skeletal-muscle weakness that may range in severity from slight depression of maximal strength to complete motor failure. These extremes of functional impairment may be seen at different times in the same patient. Any muscle may be affected. Thus, the functional impairment ranges from slight ptosis to complete respiratory failure. The course of the disease is highly variable, and prognosis is uncertain. The goal of drug therapy . . .
Ruminal lipid balance and intestinal digestion by dairy cows fed calcium salts of rapeseed oil fatty acids or rapeseed oil (1993)

The effects of supplemental calcium salts of rapeseed oil fatty acids (FA) and rapeseed oil on ruminal metabolism and apparent digestibility of lipids in the small intestine were studied using three multiparous Holstein x Friesian cows in a 3 x 3 Latin square design. Cows fitted with ruminal, duodenal, and ileal cannulas were fed restricted amounts of a control diet (C) containing 65% corn silage and 35% concentrate mix or diet C with supplemental calcium salts of rapeseed oil FA (S) or diet C supplemented with rapeseed oil (O). Fatty acid contents were 1.9, 8.4, and 7.6% for diets C, S, and O, respectively. The average flow of total FA to the duodenum was lower than the intake for supplemented treatments, suggesting catabolism of FA by ruminal microbes. Fatty acid flows at the duodenum were higher (P < .10) for diets supplemented with fat than for diet C, except for C18: 3(n-3) and straight-chain and branched-chain C15 and C17. Fat treatment affected total and individual FA flow to the ileum, except C14:0 and C18:2(n-6) and excreted amount of individual FA, except C14:0, C16:0, and total C18:1. In our trial, the addition of fat, regardless of origin, affected small intestinal digestibilities of C14:0 and C18:2(n-6) and did not affect changes in the amount of FA in the hindgut.
Real-Time Lane Detection on Suburban Streets Using Visual Cue Integration (2014)

The detection of lane boundaries on suburban streets using images obtained from video constitutes a challenging task. This is mainly due to the difficulties associated with estimating the complex geometric structure of lane boundaries, the quality of lane markings as a result of wear, occlusions by traffic, and shadows caused by road-side trees and structures. Most of the existing techniques for lane boundary detection employ a single visual cue and will only work under certain conditions and where there are clear lane markings. Also, better results are achieved when there are no other on-road objects present. This paper extends our previous work and discusses a novel lane boundary detection algorithm specifically addressing the abovementioned issues through the integration of two visual cues. The first visual cue is based on stripe-like features found on lane lines extracted using a two-dimensional symmetric Gabor filter. The second visual cue is based on a texture characteristic determined using the entropy measure of the predefined neighbourhood around a lane boundary line. The visual cues are then integrated using a rule-based classifier which incorporates a modified sequential covering algorithm to improve robustness. To separate lane boundary lines from other similar features, a road mask is generated using road chromaticity values estimated from CIE L * a * b * colour transformation. Extraneous points around lane boundary lines are then removed by an outlier removal procedure based on studentized residuals. The lane boundary lines are then modelled with Bezier spline curves. To validate the algorithm, extensive experimental evaluation was carried out on suburban streets and the results are presented.
siRNAmod: A database of experimentally validated chemically modified siRNAs (2016)

Small interfering RNA (siRNA) technology has vast potential for functional genomics and development of therapeutics. However, it faces many obstacles predominantly instability of siRNAs due to nuclease digestion and subsequently biologically short half-life. Chemical modifications in siRNAs provide means to overcome these shortcomings and improve their stability and potency. Despite enormous utility bioinformatics resource of these chemically modified siRNAs (cm-siRNAs) is lacking. Therefore, we have developed siRNAmod, a specialized databank for chemically modified siRNAs. Currently, our repository contains a total of 4894 chemically modified-siRNA sequences, comprising 128 unique chemical modifications on different positions with various permutations and combinations. It incorporates important information on siRNA sequence, chemical modification, their number and respective position, structure, simplified molecular input line entry system canonical (SMILES), efficacy of modified siRNA, target gene, cell line, experimental methods, reference etc. It is developed and hosted using Linux Apache MySQL PHP (LAMP) software bundle. Standard user-friendly browse, search facility and analysis tools are also integrated. It would assist in understanding the effect of chemical modifications and further development of stable and efficacious siRNAs for research as well as therapeutics. siRNAmod is freely available at: http://crdd.osdd.net/servers/sirnamod.
Expression of a recombinant human RGR opsin in Lentivirus-transduced cultured cells. (2000)

Our goals were to produce a functional recombinant RPE retinal G protein-coupled receptor (RGR) opsin for biochemical studies and to test the efficiency of a lentiviral vector for transgene expression of human RGR.A human RGR cDNA was cloned into a replication-defective lentiviral vector, and recombinant hRGR-Lentivirus was prepared for transduction of the ARPE-19, a human retinal pigment epithelium (RPE) cell line, and COS-7 cells. Recombinant RGR expression was detected by Western blot analysis, and functionality of the protein was tested by a [3H]all-trans-retinal binding assay.RGR protein was detected in each cell type after transduction with recombinant virus and was not observed in untreated cells. RGR expression in ARPE-19 cells increased steadily for up to 10 days after transduction and was stable for at least 6 months. The transduced ARPE-19 cells produced approximately 100-fold higher amounts of RGR protein than the transduced COS-7 cells. When cell membranes from the ARPE-19 cells were incubated with [3H]all-trans-retinal, the chromophore bound specifically to the expressed protein. Uptake of [3H]all-trans-retinol into the ARPE-19 cells was followed by specific binding of radiolabeled retinoid to RGR.Using a Lentivirus-derived gene delivery system, we were able to express high amounts of human RGR protein in the ARPE-19 human RPE cell line. The transduced ARPE-19 cells remain able to process all-trans-retinol, and the expressed protein is capable of binding to the all-trans-retinal chromophore. The Lentivirus-based expression of functional RGR can be used to study RGR in cultured cells and to test in vivo transduction of quiescent RPE cells.
Luminal prostaglandin E receptors regulate salt and water transport in rabbit cortical collecting duct (1995)

Prostaglandin E2 (PGE2) is the major renal cyclooxygenase metabolite of arachidonic acid. Urinary excretion of PGE2 is increased by dietary salt restriction, as well in cirrhosis and congestive heart failure. To determine whether urinary PGE2 affects transport along the nephron, the actions of luminal PGE2 were studied in the isolated perfused rabbit cortical collecting duct (CCD). Luminal PGE2 transiently hyperpolarized transepithelial voltage (Vt) in a dose-dependent manner (half-maximal effect approximately 10(-8) M) in contrast to a sustained depolarization of Vt produced by basolateral PGE2. Luminal PGE2 (0.1 microM) also significantly stimulated osmotic water permeability in the CCD. In CCDs cultured on semipermeable supports, apical PGE2 stimulated adenosine 3',5'-cyclic monophosphate (cAMP) production, suggesting the effects of luminal PGE2 are mediated by adenylyl cyclase-stimulating EP2 or EP4 receptors. Sulprostone, a PGE2 analogue selective for EP1 and EP3 receptors, affected Vt only when applied from the basolateral but not the luminal surface. Luminal application of the EP2 receptor agonist butaprost was also without effect. These results suggest that luminal PGE2 affects Vt via a butaprost-insensitive EP4 receptor. The Vt effect of luminal PGE2 was not blocked by pertussis toxin, also arguing against an EP3-mediated Gi-coupled effect. Finally, 1 microM luminal PGE2 only slightly increased CCD intracellular calcium concentration ([Ca2+]i), in contrast to the marked increase in [Ca2+]i produced by basolateral PGE2 (0.1 microM).(ABSTRACT TRUNCATED AT 250 WORDS)
Image Subtraction Approach to Screening One-Bead-One-Compound Combinatorial Libraries with Complex Protein Mixtures (2006)

To screen one-bead-one-compound (OBOC) combinatorial bead libraries,(1) one generally uses tagged purified protein as the screening probe. Compound beads that interact with the purified protein are then identified, for example, via an enzyme-linked colorimetric assay, and isolated for structure determination. In this report, we demonstrate a rapid and efficient method to screen OBOC combinatorial libraries utilizing two protein mixtures as screening probes, and by comparing optical images of the beads stained by one protein mixture but not the other, ligand beads unique to one of the two protein mixtures can be identified. The significance of this method is that it allows for rapid selection of ligands directed against proteins unique to one mixture while screening out positive beads resulting from proteins common to both mixtures as well as beads that are positive as a result of interactions with chemical and protein components found in the assay itself. The method is fast, efficient, and uses off-the-shelf equipment.
Pipelining and bypassing in a VLIW processor (1994)

This short note describes issues involved in the bypassing mechanism for a very long instruction word (VLIW) processor and its relation to the pipeline structure of the processor. The authors first describe the pipeline structure of their processor and analyze its performance and compare it to typical RISC-style pipeline structures given the context of a processor with multiple functional units. Next they study the performance effects of various bypassing schemes in terms of their effectiveness in resolving pipeline data hazards and their effect on the processor cycle time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
On the Distribution of the Likelihood Ratio (1954)

A classical result due to Wilks [1] on the distribution of the likelihood ratio $\lambda$ is the following. Under suitable regularity conditions, if the hypothesis that a parameter $\theta$ lies on an $r$-dimensional hyperplane of $k$-dimensional space is true, the distribution of $-2 \log \lambda$ is asymptotically that of $\chi^2$ with $k - r$ degrees of freedom. In many important problems it is desired to test hypotheses which are not quite of the above type. For example, one may wish to test whether $\theta$ is on one side of a hyperplane, or to test whether $\theta$ is in the positive quadrant of a two-dimensional space. The asymptotic distribution of $-2 \log \lambda$ is examined when the value of the parameter is a boundary point of both the set of $\theta$ corresponding to the hypothesis and the set of $\theta$ corresponding to the alternative. First the case of a single observation from a multivariate normal distribution, with mean $\theta$ and known covariance matrix, is treated. The general case is then shown to reduce to this special case where the covariance matrix is replaced by the inverse of the information matrix. In particular, if one tests whether $\theta$ is on one side or the other of a smooth $(k - 1)$-dimensional surface in $k$-dimensional space and $\theta$ lies on the surface, the asymptotic distribution of $\lambda$ is that of a chance variable which is zero half the time and which behaves like $\chi^2$ with one degree of freedom the other half of the time.
Preliminary test of a prototype of microwave axial tomograph for medical applications (2015)

An existing prototype of microwave imaging tomograph, previously designed by the present Authors for non destructive testing (NDT) applications, has been adapted in order to deal with biomedical targets. The developed system allows collecting multi-view multi-frequency data. An efficient inversion procedure is used to retrieve the distributions of the dielectric properties from the measured field samples. Some numerical simulations aimed at validating the proposed system and preliminary measurement results obtained by using a breast phantom are presented in this paper.
A 1–3-GHz Digitally Controlled Dual-RF Input Power-Amplifier Design Based on a Doherty-Outphasing Continuum Analysis (2013)

<?Pub Dtl=""?> This paper presents a linear multi-harmonic analysis method to evaluate the performance of digitally controlled dual RF-input power amplifiers (PAs). The method enables, due to its low computational cost, optimization of PA efficiency and bandwidth in a complex design space involving two independent inputs. Under the idealized assumption of short-circuited higher harmonics, the analysis is used to prove the existence of a Doherty-outphasing continuum, featuring high average efficiency over 100% fractional bandwidth. With this result as a foundation, a combiner incorporating microwave transistor parasitics is analyzed without assuming short-circuited higher harmonics, showing that high average efficiencies are also achievable under more realistic conditions. A PA is straightforwardly designed from these calculation results using two 15-W GaN HEMTs. The simulated layout-ready (large-signal transistor model) PA average drain efficiency exceeds 50% over 1.1–3.7 GHz for a 6.7-dB peak-to-average power-ratio WCDMA signal. The measured PA has a maximum output power of <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\hbox{44}} \pm {\hbox{0.9}}$</tex></formula> dBm and a 6-dB output power back-off (OPBO) power-added efficiency (PAE) of 45% over 1–3 GHz. After applying digital pre-distortion, excellent linearity is demonstrated when transmitting the WCDMA signal, resulting in an adjacent channel leakage power ratio lower than <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${-}{\hbox{57}}$</tex></formula> dBc with corresponding average PAE of 50% and 40% at 1.2 and 2.3 GHz, respectively. This is, to the authors' knowledge, the most wideband OPBO efficiency enhanced PA reported to date, proving the effectiveness of employing linear multi-harmonic analysis in dual-input PA design.
Clinical trials of agents that reverse multidrug-resistance. (1989)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1989.7.4.409 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2564427 Clinical trials of agents that reverse multidrug-resistance. M M GottesmanxM M GottesmanSearch for articles by this author , I PastanxI PastanSearch for articles by this author Show More National Cancer Institute Bethesda, MD. https://doi.org/10.1200/JCO.1989.7.4.409 First Page PDF © 1989 by American Society of Clinical Oncology
Expression of the fibroblast activation protein during mouse embryo development (2001)

Human Fibroblast Activation Protein (FAP), a member of the serine prolyl oligopeptidase family, is a type II cell surface glycoprotein that acts as a dual-specificity dipeptidyl-peptidase (DPP) and collagenase in vitro. Its restricted expression pattern in embryonic mesenchyme, in wound healing and in reactive stromal fibroblasts of epithelial cancers, has suggested a role for the FAP protease in extracellular matrix degradation or growth factor activation in sites of tissue remodeling. The FAP homologue in Xenopus laevis has been reported to be induced in the thyroid hormone-induced tail resorption program during tadpole metamorphosis supporting a role for FAP in tissue remodeling processes during embryonic development. However, Fap-deficient mice show no overt developmental defects and are viable. To study the expression of FAP during mouse embryogenesis, a second Fap-deficient mouse strain expressing beta-Galactosidase under the control of the Fap promoter was generated by homologous recombination (Fap-/- lacZ mice). FAP deficiency was confirmed by the absence of FAP-specific dipeptidyl-peptidase activity in detergent-soluble extracts isolated from 17.5 d.p.c. Fap-/- lacZ embryos. We report that Fap-/- lacZ mice express beta-Galactosidase at regions of active tissue remodeling during embryogenesis including somites and perichondrial mesenchyme from cartilage primordia.
Transmission Electron Microscopy studies in deformed Ga<sub>x</sub>In<sub>1-x</sub>As (1987)

The control of dislocation density during the growth of GaAs and related compounds is highly desirable for obtaining improved performance and reliability of opto-electronic devices. Doping of single crystal GaAs grown by the LEC process with Indium has been known to reduce the dislocation density significantly. Substitutional solid-solution strengthening of GaAs as an InAs, unit has been suggested to be responsible for reduction of dislocation density. To understand the mechanism involved in dislocation density reduction, deformation tests have been performed on [001] oriented Ga x In 1-x As single crystals in the temperature range 700-1100°C and this paper reports some results of the TEM characterization of dislocations in these deformed single crystals. Specimens of GaAs and Ga 0.99 In 0.01 As For TEM observations were made by cutting thin slices in a desired orientation, followed by mechanical polishing and ion-milling. These specimens were examined in a JEOL JEM 200CX transmission electron microscope at 200KeV equipped with a double-tilt goniometer stage.