gebhart/patrepeval huggingface dataset:
Proton nuclear magnetic resonance spectra of 1-substituted acenaphthenes and other systems of well-defined geometry (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProton nuclear magnetic resonance spectra of 1-substituted acenaphthenes and other systems of well-defined geometryChris K. Fay, John B. Grutzner, Leroy F. Johnson, Sev Sternhell, and Phillip W. WestermanCite this: J. Org. Chem. 1973, 38, 18, 3122–3136Publication Date (Print):September 1, 1973Publication History Published online1 May 2002Published inissue 1 September 1973https://pubs.acs.org/doi/10.1021/jo00958a012https://doi.org/10.1021/jo00958a012research-articleACS PublicationsRequest reuse permissionsArticle Views238Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Generalizing the Bayesian Vector Autoregression Approach for Regional Interindustry Employment Forecasting (1998)

Mark D. Partridge, Dan S. Rickman, Generalizing the Bayesian Vector Autoregression Approach for Regional Interindustry Employment Forecasting, Journal of Business & Economic Statistics, Vol. 16, No. 1 (Jan., 1998), pp. 62-72
A direct-conversion receiver for 900 MHz (ISM band) spread-spectrum digital cordless telephone (1996)

A single chip direct-conversion receiver for use in the 900 MHz ISM (industrial-scientific-medical) band has been fabricated in a 25 GHz f/sub T/ silicon-bipolar process. The receiver has a maximum gain of 105 dB with more than 80 dB of gain-control range. Integrated quadrature mixers and phase-shift networks are included. The typical phase error of the I/Q outputs is less than 1 degree. A class-AB servo amplifier is used to reduce dc offset while maintaining a turn-on time of 200 /spl mu/s. An integrated filter is included to improve channel selectivity. The integrated circuit operates on a supply voltage range of 2.7 to 5.0 V and draws 50 mA of supply current.
DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY SPECIFIC FEATURES OF DRUG ENCAPSULATION IN LIPOSOMES (A REVIEW) (2011)

Liposomes are hollow particles, the internal space of which is bounded by a lipid membrane. Liposomes are promising drug delivery systems for organs and tissues because of their colloidal properties, controlled size, surface characteristics, membrane action, and biocompatibility. Liposomal drugs have found wide use in the diagnosis and chemotherapy of cancer, vaccinology, ophthalmology, pulmonology, and the treatment of other pathologies. This review describes the methods of encapsulation of biologically active compounds with various physicochemical properties in liposomes, which is very important for the production of liposomal drugs.
Real-time cloth simulation with sparse particles and curved faces (2002)

In this paper, we present a novel technique for real-time cloth simulation. The method combines dynamic simulation and geometric techniques. Only a small number of particles (a few hundred at maximum) are controlled using dynamic simulation to simulate global cloth behaviors such as waving and bending. The cloth surface is then smoothed based on the elastic forces applied to each particle and the distance between each pair of adjacent particles. Using this geometric smoothing, local cloth behaviors such as twists and wrinkles are efficiently simulated. The proposed method is very simple, and is easy to implement and integrate with existing particle-based systems. We also describe a particle-based simulation system for efficient simulation with sparse particles. The proposed method has animated a skirt with rich details in real-time.
Sensitivity and specificity of dried blood spots for HIV-1 viral load quantification (2016)

The use of dried blood spots (DBS) instead of plasma as a specimen type for HIV-1 viral load (VL) testing facilitates the decentralization of specimen collection and can increase access to VL testing in resource-limited settings. The performance of DBS for VL testing is lower, however, when compared to the gold standard sample type plasma. In this diagnostic accuracy study, we evaluated 3 VL assays with DBS.Participants were recruited between August 2012 and April 2015. Both plasma and DBS specimens were prepared and tested for HIV-1 VL with the Roche CAP/CTM HIV-1 test v2.0, the Abbott RealTime HIV-1, and the bioMérieux NucliSENS EasyQ HIV-1 v2.0. Sensitivity and specificity to detect treatment failure at a threshold of 1000 cps/mL with DBS were determined.A total of 272 HIV-positive patients and 51 HIV-negative people were recruited in the study. The mean difference or bias between plasma and DBS VL was <0.5 log cps/mL with all 3 assays but >25% of the specimens differed by >0.5 log cps/mL.All 3 assays had comparable sensitivities around 80% and specificities around 90%. Upward misclassification rates were around 10%, but downward misclassification rates ranged from 20.3% to 23.6%. Differences in between assays were not statistically significant (P > 0.1).The 3 VL assays evaluated had suboptimal performance with DBS but still performed better than immunological or clinical monitoring. Even after the introduction of the much-anticipated point-of-care VL devices, it is expected that DBS will remain important as a complementary option for supporting access to VL monitoring, particularly in rural, resource-limited settings. Manufacturers should accelerate efforts to develop more reliable, sensitive and specific methods to test VL on DBS specimens.
Ecology of Third Creek and Associated Beaver Dams (1960)

During the summer of 1960 a comparative aquatic ecological study was carried out on Third Creek which was to be correlated with an age-growth study of brook trout in progress for the past three years on the same creek. The ecological study was done on both forks (west and east) of Upper Third Creek. All samples were collected from a total of five stations on both forks. The study included mapping, temperature determinations, chemical analyses, benthos, plankton, shore invertebrates, botanical observation and fish studies. Project Number 108.
Mutagenesis of the Rapamycin Producer Streptomyces hygroscopicus FC904. (2001)

Rapamycin (RPM) is produced by Streptomyces hygroscopicus FC904 isolated from soil in Fuzhou, China. It is a triene macrolide antibiotic with potential application as an immunosuppressant and drug for human gene therapy. In an attempt to improve rapamycin production, mutation and screening of the parent culture have been carried out. Thousands of survivors were obtained after mutagenesis by NTG (3 mg/ml) and UV (30 W, 15 cm, 30 seconds) of spore suspensions. None showed improved production of RPM. We determined the susceptibility to antibiotics of S. hygroscopicus FC904 by two fold dilutions of antibiotics in oatmeal agar plates. It was found that the strain was resistant to penicillin, erythromycin, RPM, tetracycline and chloramphenicol, but susceptible to mitomycin C (MIC, 10 microg/ml) and aminoglycosides such as gentamicin (MIC, 0.1 microg/ml), kanamycin (MIC, 0.1 microg/ml) and streptomycin (MIC, 0.3 microg/ml). Protoplasts of strain FC904 were prepared after finding the best conditions for their formation. They were treated with gentamicin, erythromycin, mitomycin C and NTG. Surprisingly, gentamicin was especially effective for obtaining higher RPM-producing mutants. Mutant C14 was selected by exposing the protoplasts of the parent strain FC904 to 1 microg/ml of gentamicin at 28 degrees C for 2 hours. A higher RPM-producing mutant (C14-1) was obtained from the protoplasts of mutant C14 treated with gentamicin, and its titer was 60% higher than that of the parent strain FC904 by HPLC analysis. Another improved mutant (C14-2) was obtained from the spores of mutant C 14 treated with 1 microg/ml of gentamicin plus 2 mg/ml of NTG at 28 degrees C for 2 hours. Mutant C14-2 had a titer 124% higher than FC904. The possible mechanism for the effect of gentamicin by using protoplasts or spore suspensions will be discussed, i.e. the possibility of gentamicin being a mutagen or a selective agent.
CLIQUE: Role-Free Clustering with Q-Learning for Wireless Sensor Networks (2009)

Clustering and aggregation inherently increase wireless sensor network (WSN) lifetime by collecting information within a cluster at a cluster head, reducing the amount of data through computation, then forwarding it. Traditional approaches, however, both spend extensive communication energy to identify the cluster heads and are inflexible to network dynamics such as those arising from sink mobility, node failure, or dwindling battery reserves. This paper presents CLIQUE, an approach for data clustering that saves cluster head selection energy by using machine learning to enable nodes to independently decide whether or not to act as a cluster head on a per-packet basis. We refer to this lack of actual cluster head assignment as being role-free, and demonstrate through simulations that, when combined with learning dynamic network properties such as battery reserves, up to 25% less energy is consumed in comparison to a traditional, random cluster head selection approach.
Conformation of coenzyme pyrroloquinoline quinone and role of Ca <sup>2+</sup> in the catalytic mechanism of quinoprotein methanol dehydrogenase (1997)

The ab initio structures of 2,7,9-tricarboxypyrroloquinoline quinone (PQQ), semiquinone (PQQH), and dihydroquinone (PQQH2) have been determined and compared with ab initio structures of the (PQQ)Ca2+, (PQQH)Ca2+, and (PQQH2)Ca2+ complexes as well as the x-ray structure of (PQQ)Ca2+ bound at the active site of the methanol dehydrogenase (MDH) of methyltropic bacteria. Plausible mechanisms for the MDH oxidation of methanol involving the (PQQ)Ca2+ complex are explored via ab initio computations and discussed. Considering the reaction of methanol with PQQ in the absence of Ca2+, nucleophilic addition of methanol to the PQQ C-5 carbonyl followed by a retro-ene elimination is deemed unlikely due to large energy barrier. A much more favorable disposition of the methanol C-5 adduct to provide formaldehyde involves proton ionization of the intermediate followed by elimination of methoxide concerted with hydride transfer to the oxygen of the C-4 carbonyl. Much the same transition state is reached if one searches for the transition state beginning with Asp-303-CO2-general-base removal of the methanol proton of the (PQQ)Ca2+O(H)CH3 complex concerted with hydride transfer to the oxygen at C-4. For such a mechanism the role of the Ca2+ moiety would be to (i) contribute to the formation of the ES complex (ii) provide a modest decrease in the pKa of methanol substrate,; and (iii) polarize the oxygen at C-5.
High performance PA-RISC Snakes motherboard I/O (2002)

A low-cost, high-performance motherboard I/O design has been developed. The design consists of 93 K gates spread across three ASIC chips and a number of PC boards. Key features of the desktop and deskside design include 20 MByte/s Fast-Wide SCSI-2, link rate FDDI, and CD quality audio. Overall motherboard disk performance was increased by a factor of four and motherboard network performance by a factor of ten. This was done while adding new CD-audio features.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Increased serum CXCL1 and CXCL5 are linked to obesity, hyperglycemia, and impaired islet function (2014)

Proinflammatory cytokines are thought to play a significant role in the pathogenesis of type 2 diabetes (T2D) and are elevated in the circulation even before the onset of the disease. However, the full complement of cytokines involved in the development of T2D is not known. In this study, 32 serum cytokines were measured from diabetes-prone BKS.Cg-m+/+Lepr(db)/J (db/db) mice and heterozygous age-matched control mice at 5 weeks (non-diabetic/non-obese), 6-7 weeks (transitional-to-diabetes), or 11 weeks (hyperglycemic/obese) and then correlated with body weight, blood glucose, and fat content. Among these 32 cytokines, C-X-C motif ligand 1 (CXCL1) showed the greatest increase (+78%) in serum levels between db/db mice that were hyperglycemic (blood glucose: 519±23 mg/dl, n=6) and those that were non-hyperglycemic (193±13 mg/dl, n=8). Similarly, increased CXCL1 (+68%) and CXCL5 (+40%) were associated with increased obesity in db/db mice; note that these effects could not be entirely separated from age. We then examined whether islets could be a source of these chemokines. Exposure to cytokines mimicking low-grade systemic inflammation (10 pg/ml IL1β+20 pg/ml IL6) for 48 h upregulated islet CXCL1 expression by 53±3-fold and CXCL5 expression by 83±10-fold (n=4, P<0.001). Finally, overnight treatment with the combination of CXCL1 and CXCL5 at serum levels was sufficient to produce a significant decrease in the peak calcium response to glucose stimulation, suggesting reduced islet function. Our findings demonstrated that CXCL1 and CXCL5 i) are increased in the circulation with the onset of T2D, ii) are produced by islets under stress, and iii) synergistically affect islet function, suggesting that these chemokines participate in the pathogenesis of T2D.
Formulaic Diction in the Cantar de mio Cid and the Old French Epic (1974)

Journal Article FORMULAIC DICTION IN THE CANTAR DE MIO CID AND THE OLD FRENCH EPIC Get access JOSEPH J. DUGGAN JOSEPH J. DUGGAN University of CaliforniaBerkeley Search for other works by this author on: Oxford Academic Google Scholar Forum for Modern Language Studies, Volume X, Issue 3, July 1974, Pages 260–269, https://doi.org/10.1093/fmls/X.3.260 Published: 01 July 1974
Interconnecting <i>L/C</i> components for decoupling and its application to low‐field open MRI array (2007)

Abstract Interconnecting L/C components are often applied to decouple the array elements for parallel imaging. Although it has been recognized that interconnecting capacitors and inductors can both be employed for decoupling, quantitative study of this decoupling technique has not yet been presented. In this study, a theoretical analysis for the interconnecting L/C decoupling circuit is provided. The analysis reveals that the required decoupling capacitance decreases with the resonant frequency, whereas the decoupling inductance is independent of the frequency. The inductive decoupling scheme is applied in the design of a four‐channel knee coil for 0.5 T open MRI with vertical magnetic field. Experimental results show that good isolations (−19 dB ∼ −45 dB) between coil elements can be achieved and only 5% ∼ 11% degeneration of Q is caused by this decoupling method. © 2007 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 31B: 116–126, 2007
Identification of Inhibitors that Block Vaccinia Virus Infection by Targeting the DNA Synthesis Processivity Factor D4 (2011)

Smallpox was globally eradicated 30 years ago by vaccination. The recent threat of bioterrorism demands the development of improved vaccines and novel therapeutics to effectively preclude a reemergence of smallpox. One new therapeutic target is the vaccinia poxvirus processivity complex, comprising D4 and A20 proteins that enable the viral E9 DNA polymerase to synthesize extended strands. Five compounds identified from an AlphaScreen assay designed to disrupt A20:D4 binding were shown to be effective in: (i) blocking vaccinia processive DNA synthesis in vitro, (ii) preventing cellular infection with minimal cytotoxicity, and (iii) binding to D4, as evidenced by ThermoFluor. The EC(50) values for inhibition of viral infectivity ranged from 9.6 to 23 μM with corresponding selectivity indices (cytotoxicity CC(50)/viral infectivity EC(50)) of 3.9 to 17.8. The five compounds are thus potential therapeutics capable of halting smallpox DNA synthesis and infectivity through disruptive action against a component of the vaccinia processivity complex.
Biomass Fractionation for the Biorefinery: Heteronuclear Multiple Quantum Coherence–Nuclear Magnetic Resonance Investigation of Lignin Isolated from Solvent Fractionation of Switchgrass (2011)

Two-dimensional heteronuclear multiple quantum coherence and quantitative (13)C nuclear magnetic resonance spectroscopy are used to identify the structural features of lignin isolated from solvent fractionation of switchgrass at several different severities. The spectra are consistent with a progressive deconstruction of the lignin as the fractionation severity increases, with structural units involved in cross-linking and capping of the bulk lignin polymer removed first, followed by increasing levels of acid-catalyzed, solvolytic cleavage of the bulk lignin. The results show that solvent fractionation conditions between about 120 °C and 0.1 M H(2)SO(4) and 160 °C and 0.025 M H(2)SO(4) are optimal for separating biomass in the biorefinery to give process streams most suitable for biobased fuel and chemical production.
Optimization of broadband transducer designs by use of statistical design of experiments (1996)

Optimizing designs that involve several parameters is a multidimensional problem, and the optimum setting of one parameter may depend on the exact setting of other parameters. Statistical design of experiments is a powerful methodology to efficiently find the optimum operating points, especially when interactions between terms is important. Here, the methodology will be described and applied to a transducer design problem to optimize bandwidth and impulse response. The design problem involves four interactive factors, the acoustic impedance of the first and second matching layer, and the appropriate thicknesses of the first and second matching layer.
Alkylpolyglycoside – Eigenschaften und Anwendungen einer neuen Tensidklasse (1998)

Eine neue Generation vielfältig nutzbarer und gleichzeitig umweltverträglicher nichtionischer Tenside sind die Alkylpolyglycoside. Ihre Herstellung aus den nachwachsenden Rohstoffen Glucose und Fettalkohol und ihr vollständiger biologischer Abbau zu Wasser, CO2 und Biomasse sind ein Beispiel für einen geschlossenen Stoffkreislauf. Aufgrund ihrer physikalisch-chemischen Eigenschaften sowie ihrer ökotoxikologischen Bewertung haben sie mittlerweile eine große Bedeutung als leistungsstarke Komponenten von Wasch-, Spül- und Reinigungsmitteln sowie von kosmetischen Erzeugnissen.
Concurrent programming without locks (2007)

Mutual exclusion locks remain the de facto mechanism for concurrency control on shared-memory data structures. However, their apparent simplicity is deceptive: It is hard to design scalable locking strategies because locks can harbor problems such as priority inversion, deadlock, and convoying. Furthermore, scalable lock-based systems are not readily composable when building compound operations. In looking for solutions to these problems, interest has developed in nonblocking systems which have promised scalability and robustness by eschewing mutual exclusion while still ensuring safety. However, existing techniques for building nonblocking systems are rarely suitable for practical use, imposing substantial storage overheads, serializing nonconflicting operations, or requiring instructions not readily available on today's CPUs. In this article we present three APIs which make it easier to develop nonblocking implementations of arbitrary data structures. The first API is a multiword compare-and-swap operation (MCAS) which atomically updates a set of memory locations. This can be used to advance a data structure from one consistent state to another. The second API is a word-based software transactional memory (WSTM) which can allow sequential code to be reused more directly than with MCAS and which provides better scalability when locations are being read rather than being updated. The third API is an object-based software transactional memory (OSTM). OSTM allows a simpler implementation than WSTM, but at the cost of reengineering the code to use OSTM objects. We present practical implementations of all three of these APIs, built from operations available across all of today's major CPU families. We illustrate the use of these APIs by using them to build highly concurrent skip lists and red-black trees. We compare the performance of the resulting implementations against one another and against high-performance lock-based systems. These results demonstrate that it is possible to build useful nonblocking data structures with performance comparable to, or better than, sophisticated lock-based designs.
Umsetzungen von <i>o</i>‐ und <i>m</i>‐Trifluormethyl‐benzaldehyd mit Diazomethan und ‐äthan (1968)

Abstract o‐Trifluormethyl‐benzaldehyd ( 1 ) gibt mit ätherischem Diazomethan das Epoxid 3 und, besonders bei Methanol‐Zusatz, das Phenylaceton 7 . Das Epoxid 3 isomerisiert bei > 180° oder im Milieu der Semicarbazon‐Bildung zum Phenylacetaldehyd 6 . Durch stufenweise Umsetzung von 2 Moll. 1 mit 1 Mol. Diazomethan entsteht neben 3 und 7 der 3‐Hydroxy‐propionaldehyd 9 , der durch Kochen mit verd. Säure zum Acrolein 11 dehydratisiert wird. Mit 2.4‐Dinitro‐phenylhydrazin ergibt 11 das Hydrazon, aus 9 entsteht das Pyrazolin 10 . Mit Diazoäthan bildet 1 den Propionaldehyd 12 und, besonders bei Methanol‐Zusatz, das Pentanon 13 . ‐ m ‐Trifluormethyl‐benzaldehyd ( 14 ) liefert mit Diazomethan das Acetophenon 15 neben einem Isomeren, vielleicht dem Epoxid 16 . Mit Diazoäthan entsteht nur das Propiophenon 17 .
중소·중견기업 CEO의 전략적 리더십과 혁신성과 간의 영향 관계에서 기술혁신의지의 매개효과 (2019)

본 연구는 최고경영자의 전략적 리더십, 최고경영자의 기술혁신의지, 혁신성과 간의 영향관계를 밝히는 것이다. 연구목적은 첫째, 전략적리더십과 기술혁신의지 간의 영향관계, 둘째, 기술혁신의지와 혁신성과 간의 영향관계, 셋째, 전략적 리더십과 혁신성과 간의 관계에서 기술혁신의지의 매개효과를 파악하고자 하였다. 전국 소재 종업원 100명 이상의 중소·중견기업 95개 회사의 최고경영자로부터 수집된 자료를 기반으로 가설을 검증한 결과, 전략적 리더십이 기술혁신의지에 긍정적인 영향을 주고, 기술혁신의지도 혁신성과에 긍정적인 영향을 주었다. 또한 전략적 리더십과 혁신성과 간의 관계에서 기술혁신의지가 매개역할을 하고 있음을 검증하였다. 본 연구는 최고경영자의 심리적 변수의 분석을 통하여 기업 차원에서의 국내 중소·중견기업 최고경영자의 역할 및 조직성장을 위한 방향성을 제시하였다는 것이다. 그 외에 연구결과에 대한 다양한 이론적 및 실무적 측면에서의 시사점, 연구의 한계점 및 향후 연구방향 등을 논의하였다.
Gas Reburning-Sorbent Injection (GR-SI): development status and field evaluation plan. Topical report, September 1986-August 1987 (1987)

This report reviews the technical basis for Gas Reburn-Sorbent Injection (GR-SI) technology for NOx/SOx control using a combined technology in which NOx is controlled from coal-fired boilers by the replacement of a portion of the coal feed by natural gas. The natural gas is injected in a manner that yields a chemical NOx reduction. Calcium based sorbents are injected into the upper furnace to absorb SO/sub 2/. An added benefit of natural gas reburning is the reduction in the mass of ash that is imposed on the boiler. The results of extensive subscale tests are reviewed to provide a current overview of the technical basis for GR-SI. At present, natural gas reburning can be optimized to yield at least a 60% NOx emission reduction. The optimized injection of calcium hydroxide will easily capture at least 50% of the SO/sub 2/. The report concludes by reviewing demonstration plans at the three Illinois power plant sites.