gebhart/patrepeval huggingface dataset:
Protection against group B meningococcal disease: evaluation of serotype 2 protein vaccines in a mouse bacteremia model (1979)

A mouse bacteremia model was used to evaluate the immunogenicity and protection against challenge provided by five different meningococcal serotype 2 vaccines. Mice vaccinated with serotype 2 protein vaccines had levels of bacteremia reduced by at least 100-fold after challenge with group B serotype 2 miningococci. Mice vaccinated with serotype 2 protein vaccine and challenged with group C serotype 2 meningococci showed 10-fold or less reduction in bacteremia. Vaccines were primarily serotype specific since no increase in protection was observed after challenge with either group B serotype 4 or group C nontypable meningococci. Serotype 2 antibody levels, measured by the bactericidal assay and the enzyme-linked immunosorbent assay 3 weeks after immunization, demonstrated a graded dose-response which correlated with protection up to 40 weeks after vaccination with a single 10- or 25-micrograms dose of serotype 2 protein vaccine. A 1-microgram booster dose of serotype 2 vaccine, given 2 weeks after primary immunization, significantly increased both bactericidal (P less than 0.01) and enzyme-linked immunosorbent assay (P less than 0.02) titers. The data obtained from the mouse bacteremia model indicate that serotype 2 protein vaccines are stable and immunogenic, and protect mice against challenge with group B serotype 2 meningococci.
Detecting Power Imbalance in Multi-Cylinder Inline Diesel Engine Genset (2010)

A model of fuel injection adjustment for balancing the 4-stroke six cylinder diesel engine coupling geneset is developed by detecting imbalance in operating engine by the frequency analysis of the crankshaft's speed variation. In this work, the crankshaft is considered to be a rigid body, so that the variation of its angular speed could be directly correlated to the total gas-pressure torque. By analyzing only the lower harmonic orders, the speed variation spectrum can filter out the distortions produced by the dynamic response of the crankshaft. The information carried by these harmonic orders permits to establish correlations between measurements and the average gas pressure torque of the engine, and to detect imbalance and identify faulty cylinders. Detailed experimental reading are taken on diesel engine coupling genset on the test bed of Greaves Cotton Ltd Pune, India.
Treatment of dystrophinopathic cardiomyopathy: review of the literature and personal results. (2012)

Cardiomyopathy is an almost universal finding in boys affected by Duchenne muscular dystrophy (DMD). Myocardial changes, as a result of the lack of dystrophin, consist of cell membrane degradation, interstitial inflammation, fatty replacement and fibrosis. Dystrophinopathic cardiomyopathy generally starts as a preclinical or intermediate stage, with evolution toward advanced stages characterized by ventricle enlargement but also by symptoms and signs of heart failure (dyspnoea, peripheral edema and liver enlargement). However in few patients the dilation could be the first manifestation of the heart involvement. The ability to detect overt cardiomyopathy increases with age, such that more than 80% of boys older than 18 years will have abnormal systolic function. Several drugs have been employed with the aim to contrast the evolution of cardiomyopathy toward stages of severe congestive heart failure. A review of cardiac treatment in DMD and personal experience are reported and discussed.
Noise Control In Planetary Transmissions (1977)

<div class="htmlview paragraph">Noise generated by vehicles has become of increasing concern, in recent years, in its effect both inside and outside the vehicle. Although the noise contributed by heavy-duty automatic transmissions in on- and off-highway vehicles is insignificant in relation to that generated by other vehicle components, a program was initiated to investigate sources and causes of transmission noise and to</div> <div class="htmlview paragraph">develop methods of reducing or eliminating that noise.</div> <div class="htmlview paragraph">In power transmission, the most common source of noise is vibration of individual gears in mesh. Two methods of decreasing gear mesh vibration have been found successful: improving gear tooth profile and counterphasing planetary gearing.</div>
Automatic article extraction in old newspapers digitized collections (2014)

We present a complete method for article segmentation in old newspapers, which deals with complex layouts analysis of degraded documents. The designed workflow can process large amounts of documents and generates digital objects in METS/ALTO format in order to facilitate the indexing and the browsing of information in digital libraries. The analysis of the document image is performed by a two stages scheme. Pixels are labeled in a first stage with a Conditional Random Field model in order to intent to label the areas of interest with a low logical level. Then this first logical representation of the document content is analyzed in a second stage to get a higher logical representation including article segmentation and reading order. This top-level structural analysis relies on the generation of an article separation grid applied recursively on the document image, allowing analyzing any type of Manhattan page layout, even for complex structures with multiple columns and overlapping entities. This method which benefits from both a local analysis using a probabilistic model trained using machine learning procedures, and a more global structural analysis using recursive rules, is evaluated on a dataset of daily local press document images covering several time periods and different page layouts, to prove its effectiveness.
Analyzing software development as a noncooperative game (2004)

A significant number of failures of software projects are widely attributed to poor requirements gathering and making various errors in specifications, choosing an incorrect architecture, following a wrong design and development model, and incurring significant cost in the maintenance stage. While these and other reasons are correct, they are based on an assumption that everyone involved in a software project is driven to make it successful and agrees on the goals and the methods of how to achieve that success. However, each team participant views the ultimate success of the project differently in terms of his/her personal goals. These different views may result in conflicting decisions by team participants that affect the overall success of the project. We analyze software projects as noncooperative games and show how to use the tools and techniques of game theory to uncover some hidden causes of failures of software projects and we suggest ways to fix them.
RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA (2014)

Dengue virus is a growing global health threat. Dengue and other flaviviruses commandeer the host cell's RNA degradation machinery to generate the small flaviviral RNA (sfRNA), a noncoding RNA that induces cytopathicity and pathogenesis. Host cell exonuclease Xrn1 likely loads on the 5' end of viral genomic RNA and degrades processively through ∼10 kB of RNA, halting near the 3' end of the viral RNA. The surviving RNA is the sfRNA. We interrogated the architecture of the complete Dengue 2 sfRNA, identifying five independently-folded RNA structures, two of which quantitatively confer Xrn1 resistance. We developed an assay for real-time monitoring of Xrn1 resistance that we used with mutagenesis and RNA folding experiments to show that Xrn1-resistant RNAs adopt a specific fold organized around a three-way junction. Disrupting the junction's fold eliminates the buildup of disease-related sfRNAs in human cells infected with a flavivirus, directly linking RNA structure to sfRNA production. DOI: http://dx.doi.org/10.7554/eLife.01892.001.
The Threat of Postmodern Totalitarianism (2019)

Once hailed as a great force for human empowerment and liberation, social media and related digital tools have rapidly come to be regarded as a major threat to democratic stability and human freedom. Based on a deeply problematic business model, social-media platforms are showing the potential to exacerbate hazards that range from authoritarian privacy violations to partisan echo chambers to the spread of malign disinformation. Authoritarian forces are also profiting from a series of other advances in digital technology, notably including the revolution in artificial intelligence (AI). These developments have the potential to fuel a "postmodern totalitarianism" vividly illustrated by China's rapidly expanding projects of digital surveillance and social control. They also pose a series of challenges for contemporary democracies.
[A new substance with nootropic activity--N-5(hydroxynicotinoyl)-L-glutamic acid]. (1990)

The psychopharmacological activity of a new compound--ONK-10--N-5(hydroxynicotinoyl)-L-glutamic acid was studied. It was shown in experiments on mice and rats that the compound possesses the pronounced antiamnestic and antihypoxic effects, does not disturb the conditioned reflex activity and the orientation behavior, has no anxiolytic activity and anticonvulsant properties, causes no disorder of movement coordination, is low toxic. ONK-10 is superior by its antiamnestic and antihypoxic effects to piracetam, meclophenoxat, demanol aceglumate and is not inferior to aniracetam.
Polarization modulation and splicing techniques for stressed birefringent fiber (1995)

A study has been conducted in the areas of polarization modulation and splicing techniques for a polarization maintaining PANDA type fiber. Polarization modulation was achieved by compressing the fiber both along the fast and slow axes. A sensitivity of 16.69 rad/(g/um) and 27.56 rad/(g/um), corresponding to a maximum phase diffrerence of 2.39 radians and 3.96 radians for compressing along the x and y birefringent axis, respectively, was achieved, with the compression material complying to a 15 degree arc around the fiber circumference. Polarization cross coupling was measured to be 0.6% for compressing with a force of 1.3 g/um. Polarization cross coupling curves were derived in terms of error in angle of applied force and polarization mode coupling alignment at the fiber input. Finite element analysis was successfully used to predict the birefringence change of the polarization modulator. Also presented are methods to improve the fiber end face perpendicularity in preparation for splicing. Two methods are proposed for detennining fiber end inclination angle with accuracy of 0.03 and 0.09 degrees. Fiber ends were prepared with inclination angles less 0.3 degrees.
Intelligent forms (1996)

This paper discusses intelligent forms and the development of distributed object-oriented intelligent form processing. Intelligent forms are described as objects at two levels: The metaphor-level and the operational level.
Src Is a Potential Therapeutic Target in Endocrine-Resistant Breast Cancer Exhibiting Low Estrogen Receptor-Mediated Transactivation (2016)

Despite the effectiveness of endocrine therapies in estrogen receptor positive (ER+) breast cancer, approximately 40% of patients relapse. Previously, we identified the Focal-adhesion kinase canonical pathway as a major contributor of resistance to estrogen deprivation and cellular-sarcoma kinase (c-src) as a dominant gene in this pathway. Dasatinib, a pan-src inhibitor, has recently been used in clinical trials to treat ER+ patients but has shown mixed success. In the following study, using isogenic cell line models, we provide a potential explanation for these findings and suggest a sub-group that may benefit. A panel of isogenic cell lines modelling resistance to aromatase inhibitors (LTED) and tamoxifen (TAMR) were assessed for response to dasatinib ± endocrine therapy. Dasatinib caused a dose-dependent decrease in proliferation in MCF7-TAMR cells and resensitized them to tamoxifen and fulvestrant but not in HCC1428-TAMR. In contrast, in estrogen-deprived conditions, dasatinib increased the proliferation rate of parental-MCF7 cells and had no effect on MCF7-LTED or HCC1428-LTED. Treatment with dasatinib caused a decrease in src-phosphorylation and inhibition of downstream pathways, including AKT and ERK1/2 in all cell lines tested, but only the MCF7-TAMR showed a concomitant decrease in markers of cell cycle progression. Inhibition of src also caused a significant decrease in cell migration in both MCF7-LTED and MCF7-TAMR cells. Finally, we showed that, in MCF7-TAMR cells, in contrast to tamoxifen sensitive cell lines, ER is expressed throughout the cell rather than being restricted to the nucleus and that treatment with dasatinib resulted in nuclear shuttling of ER, which was associated with an increase in ER-mediated transcription. These data suggest that src has differential effects in endocrine-resistant cell lines, particularly in tamoxifen resistant models, with low ER genomic activity, providing further evidence of the importance of patient selection for clinical trials testing dasatinib utility in ER+ breast cancer.
An Anthocyanin-Rich Extract of Acai (<i>Euterpe precatoria</i>Mart.) Increases Stress Resistance and Retards Aging-Related Markers in<i>Caenorhabditis elegans</i> (2016)

Acai fruits (Euterpe precatoria) are rich in antioxidant anthocyanins. Acai consumption is believed to have many health benefits; however, relevant detailed scientific investigations are limited. The current study aimed to investigate an anthocyanin-rich extract from E. precatoria fruits (AE) with regard to its antioxidant and antiaging properties using the model organism Caenorhabditis elegans. AE can protect the worms against oxidative stress and can ameliorate accumulation of reactive oxygen species in vivo. The expression of stress-response genes, such as sod-3::GFP, was upregulated while hsp-16::GFP was down-regulated after AE treatment. Studies with DAF-16/FOXO mutants indicated that some of the antioxidant effects are mediated by this transcription factor. AE can modulate the development of age-related markers, such as pharyngeal pumping. Despite the apparent antioxidant activity, no lifespan-prolonging effect was observed.
PET gantry simulation: Concepts and methods for inexpensively reproducing the PET data acquisition environment using a single PC with the PDT card (2007)

A custom PCI-application hardware card installed in a server-class PC forms a system to aid with PET data acquisition testing. This system: 1) is called the PET Gantry Simulator PC, 2) mimics most random processes as output in a coincidence-event stream from a PET detector array via fiber optics, 3) will primarily aid the development, testing and validation of PET data acquisition systems, and 4) uses a conventional server-class PC running Windows XP. This Gantry Simulator PC contains a conventional RAID disk system for fast read access into large files. In addition, this PC contains a custom-designed PETLINK™ DMA Transceiver (PDT) card with fiber-optic transceivers and PCI interface. The fiber-optic output from this PDT-in-Gantry-Simulator effectively reproduces - in several important ways - the coincidencedetection data-stream output of many types of real PET detector arrays. Significantly, this PETLINK-compatible fiber-optic retransmission of PET data (real or synthetic) can be repeated exactly and endlessly. Typically, real 64-bit PET coincidence-event and tag packet data - i.e. data collected previously in list mode form - are initially loaded onto this RAID. Under control of Windows-based custom application code, this data can be read from the RAID, input to the PDT via the PCI bus, and retransmitted from the PDT via fiber optic cables and at controlled rates. The rates of packet re-transmission can either be set to mimic that of the original PET acquisition or can be arbitrarily modified to conform to other desired scenarios - i.e. constant rate, bolus injections, half-life decay, etc. Note that the various rates of packet re-transmission are typically only updated by the PDT hardware with each passing millisecond. In one operational mode, the PDT card can be set to mimic even the Poisson distribution of the individual time delays between consecutive re- transmitted coincidence-event packets. The effective range of packet transmission rates for the Gantry Simulator approaches a low of 1 kHz and a high of 1 to 8 MHz or more.
A method for estimating the mass properties of a manipulator by measuring the reaction moments at its base (2003)

Emulating on Earth the weightlessness of a manipulator floating in space requires knowledge of the manipulator's mass properties. A method for calculating these properties by measuring the reaction forces and moments at the base of the manipulator is described. A manipulator is mounted on a six-degree-of-freedom sensor, and the reaction forces and moments at its base are measured for different positions of the links of the manipulator as well as for different orientations of its base. A procedure is developed to calculate from these measurements some combinations of the mass properties of the manipulator. The mass properties identified are not sufficiently complete for computed torque and other dynamic control techniques, but do allow compensation for the gravitational load on the links of the manipulator, and for simulation of weightless conditions on a space emulator. The algorithm has been experimentally demonstrated on a PUMA 260 and used to measure the independent combinations of the sixteen mass parameters of the base and three proximal links of the manipulator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pole-zero decision feedback equalization for the digital subscriber loop (2002)

A decision feedback equalizer (DFE) containing a feedback filter with both poles and zeros is proposed for high-speed digital communications over the subscriber loop. The feedback filter is composed of two sections; a relatively short finite-impulse-response (FIR) filter that cancels the initial part of the channel impulse response, which may contain rapid variations due to bridge taps, and a pole-zero filter than cancels the smoothly decaying tail of the impulse response. It is shown that the feedback filter can be adapted using existing infinite-impulse-response (IIR) adaptation techniques. Numerical results using a simulated subscriber loop impulse response show that a feedback filter with two poles adapted via a simplified gradient algorithm can offer significant improvement in mean squared error (MSE) (i.e., 3 to 4 dB at a signal-to-noise ratio of 20 dB) relative to a conventional DFE of the same complexity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Software-based communication latency hiding for commodity workstation networks (2002)

A variety of latency hiding techniques has been investigated at the hardware level. However, except multithreading, which may require substantial program structuring effort, other software-based latency hiding methods have not been investigated. In this paper, we consider design alternatives for latency hiding other than multithreading. Furthermore, we present experimental evidence for the validity of a new technique for software-based communication latency hiding for commodity workstation networks: Up to 89 percent of useful computational power can be squeezed out of a workstation CPU while communicating with TCP/IP via an Ethernet and almost 90 percent while communicating across the Internet.
Metabolic Clearance and Secretion Rates of Porcine Growth Hormone in Genetically Lean and Obese Swine (1976)

The metabolic clearance rate (MCR) and the secretion rate (SR) of porcine growth hormone (pGH) have been examined in swine rendered genetically either lean or obese after 18 generations of selection for or against backfat thickness. At 15 weeks of age (when the muscle:fat ratio was greater than 1) the mean half-life (t1/2), MCR, and SR, for the obese, control, and lean swine were: t1/2 = 7.4, 8.9, and 9.8 min; MCR = 341, 279, and 158 ml/min; SR = 907, 802, and 520 ng/min, respectively. At 90 kg body weight (when muscle:fat ratio was less than 1, and the age was about 30 weeks) the data for obese, control, and lean swine were: t1/2 = 11.3, 12.0, and 11.7 min; MCR =305, 280, and 336 ml/min; SR= 535, 626, and 932 ng/min, respectively. The t1/2, MCR, and SR were not significantly different among the obese, control, and lean swine at either 15 weeks or 90 kg body weight. Comparing the two stages of development, the younger swine (15 weeks of age) had a shorter t1/2 (P less than .01), and secreted and cleared more pGH on a per kg body weight basis (P less than .05) than the older swine (90 kg bodyweight, about 30 weeks of age). However, the results suggest that the selection of swine for either leanness or fatness for 18 generations did not alter the MCR and SR of pGH. In addition, the differences observed between the younger and older swine suggest that GH is cleared at a more rapid rate and more GH is available per unit of mass in the younger animals.
Synthesis and insecticidal activities of novel derivatives of podophyllotoxin (2007)

In order to find the biorational pesticides, eight novel 4beta-substituted phenoxyaniline derivatives of podophyllotoxin (4a-h) have been synthesized with significant stereoselectivity and improved yields by employing the BF(3).Et(2)O/NaI reagent system and evaluated for insecticidal activity against Pieris rapae as well as for their antifeedant effect against fifth instar larvae of P. rapae. The results showed that all these derivatives of PPT showed delayed insecticidal activity, which is different from the traditional neurotoxic insecticides. Among them, compounds possessing a 4beta-phenoxyaniline moiety substituted at para (CO(2)C(2)H(5), Cl, and OH) position exhibited greater insecticidal activity against P. rapae than podophyllotoxin. Also, the antifeedant activities showed that these compounds exhibited less potency than podophyllotoxin.
REVIEWS (1998)

Journal Article REVIEWS Get access BARBARA M BENEDICTFraming Feeling Sentiment and Style in English Prose Fiction 1745–1800 Pp 262 (AMS Studies in the Eighteenth Century 26) New York AMS Press, 1994 $45 JILL CAMPBELLNatural Masques Gender and Identity in Fielding's Plays and Novels Pp xii+324 Stanford, Calif Stanford University Press, 1995 MICHAEL IRWIN MICHAEL IRWIN University of Kent Search for other works by this author on: Oxford Academic Google Scholar The Review of English Studies, Volume 49, Issue 193, February 1998, Pages 88–90, https://doi.org/10.1093/res/49.193.88 Published: 01 February 1998
Effect of protein binding on simulated intravascular and extravascular kinetics of cefotaxime in an in vitro model (1984)

The simulated intravascular and extravascular kinetics of cefotaxime were studied in an in vitro model to evaluate the effect of antibiotic protein binding in the "intravascular" and "extravascular" space. Intravascular fluid consisted of either phosphate-buffered saline, which has no cefotaxime binding, or 3% bovine albumin, which has 63% cefotaxime binding. Extravascular spaces were filled with phosphate-buffered saline, 1.5% bovine albumin (46.6% cefotaxime binding), or 3% bovine albumin. Cefotaxime (80 mg per dose) was infused every 3 h for eight doses, and intravascular and extravascular drug concentrations were measured after doses one and eight. The corresponding intravascular and extravascular spaces were at (phosphate-buffered saline) or approaching (3% bovine albumin) equilibrium by dose eight. There were marked differences in drug concentrations achieved in the various extravascular spaces, but all could be explained on the basis of differing amounts of albumin present and the resultant differences in cefotaxime binding.