gebhart/patrepeval huggingface dataset:
Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase. (1994)

In a murine interleukin 3 (IL-3)-dependent cell line, IL-3 deprivation resulted in increased autophosphorylation of double-stranded RNA-dependent protein kinase (PKR) that has been reported to inhibit protein synthesis by phosphorylating the alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha). Autophosphorylation was characterized by a shift up in mobility of PKR on SDS/PAGE gels from a 60- to a 64-kDa form. In vitro kinase studies comparing the autophosphorylated 64-kDa PKR with the nonphosphorylated 60-kDa PKR confirmed that only the 64-kDa form was active for eIF-2 alpha phosphorylation. PKR activation in vivo was associated with phosphorylation of eIF-2 alpha and inhibition of protein synthesis. Addition of IL-3 to deprived cells elicited a reciprocal response characterized by the rapid dephosphorylation of PKR and eIF-2 alpha, indicating inactivation of PKR. This was rapidly followed by the full recovery of protein synthesis. Furthermore, upon IL-3 addition, a 97-kDa phosphotyrosine-containing protein becomes rapidly and transiently associated with PKR prior to dephosphorylation of PKR and eIF-2 alpha. Genistein, a tyrosine kinase inhibitor, blocks both phosphorylation of the 97-kDa phosphoprotein and protein synthesis after IL-3 addition, suggesting a role for the 97-kDa phosphoprotein in the mechanism of inactivation of PKR and stimulation of protein synthesis. Thus, IL-3 appears to positively regulate protein synthesis by inducing the inactivation of PKR in a growth factor signaling pathway.
Hepatic dearterialization for nonresectable primary and secondary tumors of the liver (1976)

Seventeen patients with primary or secondary liver tumors were treated by dearterialization of the liver and intraportal infusion of cytotoxic drugs. In 14 cases, ligation of the main (10), right and left (1), right and middle (1), and right (2) hepatic arteries was performed. In three in whom hepatic artery ligation was considered to be contraindicated due to occlusion of the portal vein, temporary occlusion of the hepatic artery was repeated postoperatively. Only one patient died from the cause related to the ligation. Out of 14 patients who survived for more than one month ten showed an apparent regression of tumors radiologically. The mean survival period of the patients excluding those who died from other unrelated causes was 28 weeks. That of the control patients who received only chemotherapy through the hepatic artery was 13 weeks. The results were not always satisfactory, but dearterialization of the liver can be a palliative treatment for nonresectable liver tumors with a forceful combined chemotherapy.
<title>Video coding of model based at very low bit rates</title> (2003)

Very low bit rate coding is an important part of the MPEG-4 standard. To obtain maximum compression in videoconference sequences a technique called model-based coding can be used. With this technique, the face of the speaker is represented by a model, and its movement between frames is coded with a small set of parameters. As with all MPEG standards, the encoder algorithm is not described and this leaves the door open to many possible implementations. In this paper, a summary of model-based coding is presented. Many fields have been studied, including 3D wire-frame models, face detection, facial feature extraction, motion parameter estimation, and face model parameter coding. Several problems need to be solved before model-based video communication will become practical. Some of them are discussed in this paper, such as how to detect and locate a face in an image, how to extract parameters from an image to adapt a face model, and how to compress the animation parameters.
Arbitrary precise orientation specification for layout of text (2002)

A novel method for the layout of text strings over some given free-form parametric base curves is considered. Each letter of the string is represented by a collection of cubic and linear Bezier curves. The layout of the string over the free-form parametric curve is derived as a symbolic composition of the string geometry (i.e. a sequence of Bezier curves) and a free-form parametric surface S(u, v) with the parameters u, v between zero and one, and S(u, 0) given by the base curve. This method has proven to provide great flexibility and give high quality results in layout of text.
THE ROYAL MUSIC (1937)

THE ROYAL MUSIC Get access PERCY YOUNG PERCY YOUNG Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume XVIII, Issue 2, April 1937, Pages 119–127, https://doi.org/10.1093/ml/XVIII.2.119 Published: 01 April 1937
A Comprehensive Approach to Developing and Integrating Multilingual Classifications: GALEN's Classification Workbench (1998)

The GALEN Classification Workbench presents a new user-oriented paradigm for maintaining terminologies which combines flexibility with formal rigour. It is based on three mechanisms: a user oriented ‘intermediate representation’, a formal description logic, and generated natural language. New terms are composed in the ‘intermediate representation’ which is transformed into the formal description logic from which natural language phrases are then generated. The formal description logic allows terms to be classified and manipulated rigorously while the intermediate representation and generated natural language allow the system to be tailored to the needs of individual users and applications.
Multifunctional Superparamagnetic Janus Particles (2009)

In this study, we report the microfluidic-based synthesis of a multifunctional Janus hydrogel particle with anisotropic superparamagnetic properties and chemical composition for the bottom-up assembly of hydrogel superstructures. In a uniform magnetic field, the resulting Janus magnetic particles fabricated in the present method exhibit chainlike or meshlike superstructure forms, the complexity of which can be simply modulated by particle density and composition. This controllable field-driven assembly of the particles can be potentially used as building blocks to construct targeted superstructures for tissue engineering. More importantly, we demonstrated that this method also shows the ability to generate multifunctional Janus particles with great design flexibilities: (a) direct encapsulation and precise spatial distribution of biological substance and (b) selective surface functionalization in a particle. Although these monodisperse particles find immediate use in tissue engineering, their ability to self-assemble with tunable anisotropic configurations makes them an intriguing material for several exciting areas of research such as photonic crystals, novel microelectronic architecture, and sensing.
Thiol-protein disulphide oxidoreductases. Assay of microsomal membrane-bound glutathione-insulin transhydrogenase and comparison with protein disulphide-isomerase (1976)

1. Inhibition of endogenous microsomal NADPH oxidase by CO enables membrane-bound glutathione-insulin transhydrogenase (EC 1.8.4.2) to be assayed conveniently by a linked assay involving NADPH and glutathione reductase (EC 1.6.4.2). 2. The specific activity of the enzyme in rat liver microsomal preparations is of the order of 1 nmol of oxidized glutathione formed/min per mg of membrane protein. 3. The specific activity of the enzyme is comparable in rough and smooth microsomal fractions, and the activity is not affected by treatment with EDTA and the removal of ribosomes from rough microsomal fractions. 4. Membrane-bound glutathione-insulin transhydrogenase is not affected by concentrations of deoxycholate up to 0.5%, whereas protein disulphide-isomerase (EC 5.3.4.1) is drastically inhibited. 5. On these grounds it is concluded that, in rat liver microsomal fractions, glutathione-insulin transhydrogenase and protein disulphide-isomerase activities are not both catalysed by a single enzyme species.
Structural Basis for the Inhibition of the LSD1 Histone Demethylase by the Antidepressant <i>trans</i>-2-Phenylcyclopropylamine<sup>,</sup> (2007)

Histone modifications, such as acetylation and methylation, are important epigenetic marks that regulate diverse biological processes that use chromatin as the template, including transcription. Dysregulation of histone acetylation and methylation leads to the silencing of tumor suppressor genes and contributes to cancer progression. Inhibitors of enzymes that catalyze the addition and removal of these epigenetic marks thus have therapeutic potential for treating cancer. Lysine-specific demethylase 1 (LSD1) is the first discovered histone lysine demethylase and, with the help of its cofactor CoREST, specifically demethylates mono- and dimethylated histone H3 lysine 4 (H3-K4), thus repressing transcription. Because LSD1 belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases, certain inhibitors of monoamine oxidases (MAOs), including the clinically used antidepressant trans-2-phenylcyclopropylamine (PCPA; tranylcypromine; Parnate), are also capable of inhibiting LSD1. In this study, we have further measured the kinetic parameters of the inhibition of LSD1 by PCPA and determined the crystal structure of LSD1-CoREST in the presence of PCPA. Our structural and mass spectrometry analyses are consistent with PCPA forming a covalent adduct with FAD in LSD1 that is distinct from the FAD-PCPA adduct of MAO B. The structure also reveals that the phenyl ring of the FAD-PCPA adduct in LSD1 does not form extensive interactions with active-site residues. This study thus provides the basis for designing more potent inhibitors of LSD1 that contain substitutions on the phenyl ring of PCPA to fully engage neighboring residues.
Nuclear cardiology : state of the art and future directions (1993)

Brings together the latest research on the use and development of radionuclides for all aspects of cardiovascular imaging diagnosis. The book covers topics of both investigative and clinical interest, including tissue tracer kinetics, ventricular function and myocardial perfusion imaging.
Hybrid Speed Control of Sensorless Brushless Dc Motor with Fuzzy-Based Estimation (2012)

This paper describes a simple way to control the Brushless DC (BLDC) motor for electrical applications. To control this machine, it is generally required to measure the speed and position of the rotor by using the sensor, because the inverter phases acting at any time must be commutated depending on the rotor position. Encoders and resolvers have been used for sensing the rotor position with respect to the stator. These sensors, however, make the motor system more complicated and mechanically unreliable. A method for the estimation of the speed and rotor position of a BLDC motor is presented in this paper. Fuzzy-based back-EMF observer is employed to estimate the speed by using measurements of the stator line voltage and line current. Most existing sensorless methods of the BLDC motor have low performance in a transient state or low-speed range and occasionally require an additional circuit. To overcome this problem, the estimation of back-EMF is carried out by fuzzy logic techniques to improve the performance of the system. This method proposes a back-EMF observer based on fuzzy function approximation and the system state equation of the BLDC motor and describes a fuzzy logic approach to design a Hybrid Controller (HC) for variable speeds of a BLDC motor. Here, Proportional Integral (PI) controller is tuned by the fuzzy logic technique. The fuzzy logic tuner is used to adjust the two gains of the PI controller. In this approach, the fuzzy tuning of the gains of a conventional PI controller is achieved through fuzzy rules deduced from many simulation tests applied to BLDC motor, for a variety of operating conditions. Experimental results show that the proposed fuzzy-tuning PI controller is better than the controller with fixed gains in terms of robustness and speed rise time even under great variations of operating conditions and load disturbance.
Bistatic GPR system for landmine detection using optical electric field (2004)

Ground penetrating radar (GPR) is one promising technique for land mine detection, and many researches have been carried out. Most of the ideas for landmine detection by GPR use a monostatic type radar system, which is suitable for detecting land mines buried in shallow soil, which is normally less than 10 cm. On the other hand, bistatic type radar will be suitable for stand-off detection. In this paper, we propose a novel bistatic radar system, which uses an optical electric field sensor as a receiver. Some fundamental field test results are shown in this report.
Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements. (1991)

Expression of the high-affinity receptor for IgG (Fc gamma RI) is restricted to cells of myeloid lineage and is induced by gamma-interferon (IFN-gamma) but not by IFN-alpha/beta. The organization of the human Fc gamma RI gene has been determined and the DNA elements governing its cell type-restricted transcription and IFN-gamma induction are reported here. A 39-nucleotide sequence (IFN-gamma response region, or GRR) is defined that is both necessary and sufficient for IFN-gamma inducibility. Sequence analysis of the GRR reveals the presence of promoter elements initially defined for the major histocompatibility complex class II genes: i.e., X, H, and gamma-IRE sequences. Comparison of a number of genes whose expression is induced selectively by IFN-gamma indicates that the presence of these elements is a general feature of IFN-gamma-responsive genes. Our studies suggest that the combination of X, H, and gamma-IRE elements is a common motif in the pathway of transcriptional induction by this lymphokine.
Evaluation of graft flow between on-pump and off-pump coronary artery bypass grafting (2012)

Background: Coronary artery bypass grafting (CABG) is an effective method to afford sufficient blood flow for that ischemic myocardium. Off-pump coronary bypass surgery (OPCAB) has been rediscovered and refined to avoid cardiopulmonary bypass. However, it’s a high technique demanding skill. And evaluation of the blood flow should be reliable. Transit time flow measurement (TTFM) is introduced to evaluate graft flow and anastomosis patency intraoperatively. The accuracy of graft flow depends on how to explain the parameters of TTFM. Here, we introduce our experiences on the explanation of TTFM parameters. Objective: We compared the graft patency of off-pump coronary artery bypass grafting with those of on-pump coronary artery bypass grafting by intraoperative transit time flow measurement (TTFM). Methods: Three hundred patients were divided into off-pump group and on-pump group. TTFM was routinely performed for assessment of graft patency during operation. Revision of the grafts depends on the TTFM findings. Results: One patient in OPCAB group was converted to conventional CABG group due to ventricular fibrillation. One patient died of multiple organ failure 21 days post-operation. Seven grafts were revised based on unsatisfactory TTFM findings. There was no statistical difference in the variables between the two groups except for anastmosis to right coronary artery. Conclusions: Off-pump surgery can provide the same flow of grafts as that of on-pump surgery. TTFM is an effective tool to decide if a well-function graft is or not, and it allows for revision of failure graft during operation. Keywords: Backward flow percentage, coronary artery bypass grafting, pulsatile index, revascularization, transit time flow measurement
Triggered Source of Single Photons based on Controlled Single Molecule Fluorescence (1999)

We use the method of adiabatic following to prepare a single molecule in its fluorescing excited state. Spontaneous emission from this state gives rise to a single photon. With our current experimental conditions, up to $74%$ of the sweeps lead to the emission of a single photon. Since the adiabatic passage is done on command, the molecule performs as a high rate source of triggered photons. The experimental results are in quantitative agreement with quantum Monte Carlo simulations.
Editorial. Transgene containment by molecular means - is it possible and cost effective? (2003)

With the rapid advancement of transgenic biotechnology, large numbers of transgenic crops have been produced and released for commercial cultivation (James, 2001), raising considerable biosafety concerns all over the world. One of the major issues is the potential ecological risk resulting from transgenes escaping into and persist- ing in the environment. The extensive on-going debate on this issue (Arriola, 1997; Wolfenbarger and Phifer, 2000; Crawley et al., 2001; Prakash, 2001; Dale et al., 2002) poses challenging questions regarding the research direc- tions that need to be taken to ensure that biotechnology outputs are responsibly deployed worldwide. Unless these biosafety issues are satisfactorily addressed, large-scale commercial release of the transgenic crops developed and further advancement of transgenic bio- technology are likely to be hampered. For an in-depth review of crop-to-wild gene flow, see Jenczewski et al. (2002) in this number of EBR. Here the more specific issue of the effectiveness of preventing gene flow from occurring will be discussed.
A Clinical Trial of Intravenous Peramivir Compared with Oral Oseltamivir for the Treatment of Seasonal Influenza in Hospitalized Adults (2012)

Treatment of acute seasonal influenza in hospitalized adults with either peramivir or oseltamivir resulted in generally similar clinical outcomes. Treatment with peramivir was generally safe and well tolerated and could be of benefit in this population.
An Efficient Linux Kernel Implementation of Service Function Chaining for Legacy VNFs Based on IPv6 Segment Routing (2019)

We consider the IPv6 Segment Routing (SRv6) technology for Service Function Chaining of Virtual Network Functions (VNFs). Most of the VNFs are legacy VNFs (not aware of the SRv6 technology) and expect to process traditional IP packets. An SR proxy is needed to support them. We have extended the implementation of SRv6 in the Linux kernel, realizing an open source SR-proxy, referred to as SRNK (SR-Proxy Native Kernel). The performance of the proposed solution (SRNKvl) has been evaluated, identifying a poor scalability with respect to the number of VNFs to be supported in a node. Therefore we provided a second design (SRNKv2), enhancing the Linux Policy Routing framework. The performance of SRNKv2 is independent from the number of supported VNFs in a node. We compared the performance of SRNKv2 with a reference scenario not performing the encapsulation and decapsulation operation and demonstrated that the overhead of SRNKv2 is very small, on the order of 3.5%.
Gaseous Ion Recombination Rates. II (1964)

An analysis of the mechanics of three-body ion recombination is given. The relative efficiencies of various gases in promoting ion recombination are calculated and found to be in satisfactory agreement with experiment. The calculations lead to qualitative conclusions about how mass, relative velocity, and the nature of the deactivation criterion affect the magnitude of the recombination rate.
Observation of far-infrared emission from excited cytosine molecules (2005)

We report a time-resolved investigation of the resonant absorption of far-infrared radiation and the subsequent vibrational relaxation processes in a sample of polycrystalline cytosine at 4K, using terahertz time-domain spectroscopy. The subpicosecond time resolution achieved in our experiments corresponds to a near single-cycle of far-infrared radiation, and this enables us to observe the damped oscillations of the electric field produced by excited molecules as they decay. Furthermore, we show that the progressive absorption and subsequent emission of far-infrared radiation at the frequency of the corresponding vibrational mode can be followed directly as a function of time by means of time-partitioned Fourier transforms of the transmitted signal.
Electronic versus traditional chest tube drainage following lobectomy: a randomized trial (2015)

Electronic drainage systems did not reduce chest tube duration or length of hospitalization significantly compared with traditional water seal drainage when a strict algorithm for chest tube removal was used. This algorithm allowed delegation of chest tube removal to staff nurses, and in some patients chest tubes could be removed safely on the day of surgery.
0.8-μm band optical isolator for fiber-optic communication (1979)

With the development of fiber-optic communication, need has arisen for optical isolators that prevent laser diodes from unstable operation caused by optical feedback from the fiber input facet and/or connector interfaces of the optical fiber transmission line. Compact optical isolators for the visible region and for the wavelength region longer than 1 μm have been reported.1,2.
Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2 (2000)

Human CD81 has been previously identified as the putative receptor for the hepatitis C virus envelope glycoprotein E2. The large extracellular loop (LEL) of human CD81 differs in four amino acid residues from that of the African green monkey (AGM), which does not bind E2. We mutated each of the four positions in human CD81 to the corresponding AGM residues and expressed them as soluble fusion LEL proteins in bacteria or as complete membrane proteins in mammalian cells. We found human amino acid 186 to be critical for the interaction with the viral envelope glycoprotein. This residue was also important for binding of certain anti-CD81 monoclonal antibodies. Mutating residues 188 and 196 did not affect E2 or antibody binding. Interestingly, mutation of residue 163 increased both E2 and antibody binding, suggesting that this amino acid contributes to the tertiary structure of CD81 and its ligand-binding ability. These observations have implications for the design of soluble high-affinity molecules that could target the CD81-E2 interaction site(s).
The Inverse of the Cumulative Standard Normal Probability Function (2003)

Some properties of the inverse of the function $N\lpar x\rpar = \lpar1/\sqrt{2\pi}\rpar \vint_{-\infty}^{x}e^{-t^2/2}\,\hbox{d}t$ are studied. Its derivatives, integrals and asymptotic behavior are presented.
Beam steering performance of compressed Luneburg lens based on transformation optics (2018)

In this paper, two types of compressed Luneburg lenses based on transformation optics are investigated and simulated using two different sources, namely, waveguides and dipoles, which represent plane and spherical wave sources, respectively. We determined that the largest beam steering angle and the related feed point are intrinsic characteristics of a certain type of compressed Luneburg lens, and that the optimized distance between the feed and lens, gain enhancement, and side-lobe suppression are related to the type of source. Based on our results, we anticipate that these lenses will prove useful in various future antenna applications.
Preparation of Pb(Mg<sub>1/3</sub>Nb<sub>2/3</sub>)O<sub>3</sub> Relaxor Ferroelectric by Sol-Gel Route (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.