gebhart/patrepeval huggingface dataset:
Simulation Analysis on Characteristics of a Planar Capacitive Sensor for Large Scale Measurement (2009)

Measuring multi-dimensional linear displacements in large scale range with high precision is always focused on by researchers. This paper presents the results of simulation analysis on characteristics of a planar capacitive sensor (PCS), which is proposed for X and Y direction linear displacement measurement by measuring the periodic change of capacitance between two periodic plates, one fixed (i.e. fixed plate) and the other movable (i.e. movable plate). Since the capacitive electrode array on the fixed plate is periodically positioned, large scale measurement is realizable as long as the electrode array is large enough. The use of two geometrical orthogonal (90-degree out-of-phase) electrode arrays on the movable plate promises either axial displacement can be measured simultaneously without the coupling of another axial movement. The result of simulation proves 2-dimensional large scale measurement is feasible, meanwhile, different strategies are presented to fulfill structural optimization, including sensitivity optimization and linearity optimization.
The Corporate Identity of the Canadian Government (1991)

Journal Article The Corporate Identity of the Canadian Government Get access MICHAEL LARGE MICHAEL LARGE Concordia University, Montreal Search for other works by this author on: Oxford Academic Google Scholar Journal of Design History, Volume 4, Issue 1, 1991, Pages 31–42, https://doi.org/10.1093/jdh/4.1.31 Published: 01 March 1991
Recrystallization effects and grain size in Bi-2223 tapes (1998)

Bi-2223 precursor powders with different stoichiometries and synthesized using different heat treatments were compared with powders obtained from external sources in powder-in-tube tapes. In the final microstructure, it was found that the Bi-2223 grain size varied considerably between tapes made from different powders. The critical current density was found to increase with increasing grain size. Among the factors found to determine the Bi-2223 grain size were powder stoichiometry and Bi-2212 recrystallization rate.
Studies of Inhibitor Binding to Escherichia coli Purine Nucleoside Phosphorylase Using the Transferred Nuclear Overhauser Effect and Rotating-Frame Nuclear Overhauser Enhancement (1994)

NMR studies of the adenosine analog tubercidin have been carried out in the presence of Escherichia coli purine nucleoside phosphorylase (PNP) in order to characterize the conformation of the enzyme-complexed nucleoside. Although analysis of transferred NOE data at various enzyme/inhibitor ratios indicated a predominantly syn nucleoside conformation in the enzyme-complexed state, the results, particularly the 8(1') and 8(3') NOE interactions, were not quantitatively consistent with any single bound conformation. Dissociation rate constants for the tubercidin-PNP complex were determined based on analysis of chemical shift and line width data as a function of enzyme/inhibitor ratio, Carr-Purcell-Meiboom-Gill measurements of the transverse relaxation rate as a function of pulse rate, and T1 rho experiments as a function of the spin-lock field strength. Dissociation rate constants of 2100 s-1 at 20 degrees C and 1400 s-1 at 10 degrees C were determined using the latter two methods. These rates are sufficiently high to justify the validity of the transferred NOE method for an enzyme as large as PNP. The possible significance of spin diffusion was investigated by the use of the deuterated analog [2'-2H]tubercidin, for which many of the intraligand spin diffusion pathways are eliminated, and by performing a series of transferred ROE experiments. A comparison of data obtained using transferred NOE and ROE measurements provides a basis for separating direct and indirect relaxation pathways. Both approaches indicated that the relatively significant 8(3') NOE interaction was not dominated by spin diffusion. Furthermore, analysis of chemical shift and transverse relaxation data for the tubercidin H-2 resonance gave inconsistent results for the chemical shift of the bound species and was inconsistent with the assumption of a single, bound conformation. These results were interpreted in terms of a 2:1 ratio of a syn, 3'-exo:anti, 3'-endo geometry for bound tubercidin. Ligand competition experiments using 9-deazainosine show that all of the tubercidin TRNOE effects are reversed by addition of the second nucleoside, suggesting that the TRNOE data for tubercidin arise due to interactions at the active sites of PNP rather than as a consequence of nonspecific binding to the enzyme.
Usefulness of a Test for Slime Production as a Marker for Clinically Significant Infections with Coagulase-Negative Staphylococci (1986)

The usefulness of a test for slime production as a marker for clinically significant infections with coagulase-negative staphylococci and its implications for therapy were examined. Hospital records were reviewed for 59 patients from each of whom more than one isolate of coagulase-negative staphylococci was obtained. In patients with a prosthetic device, 81% of 59 infectious episodes were due to a slime-positive coagulase-negative staphylococci. In contrast, 22 noninfectious episodes (in which the organisms were contaminants) were equally distributed between episodes due to slime-positive or slime-negative isolates (P = .005). Only 32% of infections caused by slime-positive organisms, in contrast to 100% of infections caused by slime-negative organisms, were improved by treatment with antibiotics alone (P = .02). Prosthetic device removal in addition to antibiotic treatment significantly improved the outcome in patients with infections due to slime-positive organisms when compared with treatment with antibiotics alone (93% vs. 32% improvement; P = .00025).
MRI analysis of 3D normal and post-glossectomy tongue motion in speech (2013)

Measuring the internal muscular motion and deformation of the tongue during natural human speech is of high interest to head and neck surgeons and speech language pathologists. A pipeline for calculating 3D tongue motion from dynamic cine and tagged Magnetic Resonance (MR) images during speech has been developed. This paper presents the result of a complete analysis of eleven subjects' (seven normal controls and four glossectomy patients) global tongue motion during speech obtained through MR imaging and processed through the tongue motion analysis pipeline. The data is regularized into the same framework for comparison. A generalized two-step principal component analysis is used to show the major difference between patients' and controls' tongue motions. A test is performed to demonstrate the ability of this process to distinguish patient data from control data and to show the potential power of quantitative analysis that the tongue motion pipeline can achieve.
Selective excitation of vortex fibre modes using a spatial light modulator (2005)

A controllable excitation of fibre modes is examined theoretically and experimentally. We verify that the modes of a few-mode fibre can be selectively excited by means of a spatial light modulation of a laser beam focused to the fibre. The proposed method is demonstrated on a dynamical switching, phase coupling and weighted mixing of LP01, LP11 and LP21 modes, achieved by an exchange of computer-generated holograms sent to the spatial light modulator. The possibility to excite a vortex fibre mode with a well-defined azimuthal phase dependence is also verified. It is promising for an encoding and transfer of information by vortices in fibre communications.
On direction finding of an emitting source from time delays (1999)

This paper presents a statistically and computationally efficient algorithm for direction finding of a single far-field source using a multi-sensor array. The algorithm extracts the azimuth and elevation angles directly from the estimated time delays between the array elements. Hence, it is referred to herein as the time delay direction finding (TDDF) algorithm. An asymptotic performance analysis, using a small error assumption, is conducted. For any 1-D and 2-D array configurations, it is shown that the TDDF algorithm achieves the Cramer Rao lower bound (CRLB) for the azimuth and elevation estimates provided that the noise is Gaussian and spatially uncorrected and that the time delay estimator achieves the CRLB as well. Moreover, with the suggested algorithm no constraints on the array geometry are required. For the general 3-D case the algorithm does not achieve the CRLB for a general array. However, it is shown that for array geometries which obey certain constraints the CRLB is achieved as well. The TDDF algorithm offers several advantages over the beamforming approach. First, it is more efficient in terms of computational load. Second, the azimuth estimator does not require the a priori knowledge of the wave propagation velocity. Third, the TDDF algorithm is suitable for applications where the arrival time is the only measured input, in contrast to the beamformer, which is not applicable in this case.
The phosphotransferase system (PTS) of <i>Streptomyces coelicolor</i> (1999)

HPr, the histidine-containing phosphocarrier protein of the bacterial phosphotransferase system (PTS) controls sugar uptake and carbon utilization in low-GC Gram-positive bacteria and in Gram-negative bacteria. We have purified HPr from Streptomyces coelicolor cell extracts. The N-terminal sequence matched the product of an S. coelicolor orf, designated ptsH, sequenced as part of the S. coelicolor genome sequencing project. The ptsH gene appears to form a monocistronic operon. Determination of the evolutionary relationship revealed that S. coelicolor HPr is equally distant to all known HPr and HPr-like proteins. The presumptive phosphorylation site around histidine 15 is perfectly conserved while a second possible phosphorylation site at serine 47 is not well-conserved. HPr was overproduced in Escherichia coli in its native form and as a histidine-tagged fusion protein. Histidine-tagged HPr was purified to homogeneity. HPr was phosphorylated by its own enzyme I (EI) and heterologously phosphorylated by EI of Bacillus subtilis and Staphylococcus aureus, respectively. This phosphoenolpyruvate-dependent phosphorylation was absent in an HPr mutant in which histidine 15 was replaced by alanine. Reconstitution of the fructose-specific PTS demonstrated that HPr could efficiently phosphorylate enzyme IIFructose. HPr-P could also phosphorylate enzyme IIGlucose of B. subtilis, enzyme IILactose of S. aureus, and IIAMannitol of E. coli. ATP-dependent phosphorylation was detected with HPr kinase/phosphatase of B. subtilis. These results present the first identification of a gene of the PTS complement of S. coelicolor, providing the basis to elucidate the role(s) of HPr and the PTS in this class of bacteria.
Effects of simmondsin on food intake, growth, and metabolic variables in lean (+/?) and obese (<i>fa/fa</i>) Zucker rats (1999)

Incorporation of 2.5 g/kg of the anorexigen, simmondsin, in the diet resulted in food intake reduction in both lean and obese Zucker rats; however, the obese rats were much more sensitive to the food intake-reducing activity of simmondsin. In both obese and lean simmondsin-treated Zucker rats, growth was slower than in control rats, but was the same as that in pair-fed animals. The 24 h heat production pattern showed a smaller diurnal variation and a lower mean in obese rats than in lean rats. Food intake reduction, as a result of either simmondsin treatment or pair feeding, caused a decrease in mean heat production. Simmondsin treatment, but not pair feeding, caused a decrease in the diurnal variation of heat production. Plasma total cholesterol levels were increased in both simmondsin-treated and pair-fed obese and lean Zucker rats compared with control animals; this increase was mainly due to an increase in HDL-cholesterol levels. Blood leptin levels in both obese and lean rats decreased with decreased food intake and decreased fat deposition, but in obese rats, simmondsin treatment resulted in an additional decrease in leptin levels. It is concluded that the food intake-reducing effect of simmondsin is more pronounced in obese Zucker rats than in their lean littermates, and except for the simmondsin-specific effects on leptin and total cholesterol values in obese littermates, the effects of simmondsin are related to food intake restriction in obese and lean Zucker rats.
Synergistic Action of Amphotericin B and Antioxidants Against Certain Opportunistic Yeast Pathogens (1978)

Results of earlier turbidimetric growth experiments showed that certain antioxidants prolonged the antifungal activity of amphotericin B (AB) against Candida albicans, presumably by retarding autoxidative destruction of the drug. Viability studies were designed to examine this in more detail. Subinhibitory concentrations of either butylated hydroxyanisole, n-propyl gallate, or nordihydroguaiaretic acid in combination with fungistatic levels of AB exerted synergistic fungicidal activity against two strains of C. albicans and one of C. parapsilosis. Although synergism was not seen in tests with a strain of Torulopsis glabrata, antioxidants prolonged the inhibitory action of AB against this organism. On the basis of these findings and other considerations that are discussed, it is suggested that stabilization of AB and the ability to act synergistically with AB represent two distinctly different effects of the antioxidants.
The Enron Email Dataset Database Schema and Brief Statistical Report (2004)

Email logs have been considered as a useful resource for research in fields like link analysis, social network analysis and textual analysis. Most of the experiments in these fields of research are performed on synthetic data due to lack of an adequate and real life benchmark. The Enron email dataset is a touchstone for such research. This dataset is very similar to the kind of the data collected for fraud detection and
A New Property Coding in Text Steganography of Microsoft Word Documents (2014)

The phylum Nematoda remains very poorly sampled for mtDNA, with a strong bias toward parasitic, economically important or model species of the Chromadoria lineage. Most chromadorian mitogenomes share a specific order of genes encoded on one mtDNA strand. However, the few sequenced representatives of the Dorylaimia lineage exhibit a variable order of mtDNA genes encoded on both strands. While the ancestral arrangement of nematode mitogenome remains undefined, no evidence has been reported for Enoplia, the phylum's third early divergent major lineage. We describe the first mitogenome of an enoplian nematode, Campydora demonstrans, and contend that the complete 37-gene repertoire and both-strand gene encoding are ancestral states preserved in Enoplia and Dorylaimia versus the derived mitogenome arrangement in some Chromadoria. The C. demonstrans mitogenome is 17,018 bp in size and contains a noncoding perfect inverted repeat with 2013 bp-long arms, subdividing the mitogenome into two coding regions. This mtDNA arrangement is very rare among animals and instead resembles that of chloroplast genomes in land plants. Our report broadens mtDNA taxonomic sampling of the phylum Nematoda and adds support to the applicability of cox1 gene as a phylogenetic marker for establishing nematode relationships within higher taxa.
On Gradient Descent Algorithm for Generalized Phase Retrieval Problem (2016)

In this paper, we study the generalized phase retrieval problem: to recover a signal $\bm{x}\in\mathbb{C}^n$ from the measurements $y_r=\lvert \langle\bm{a}_r,\bm{x}\rangle\rvert^2$, $r=1,2,\ldots,m$. The problem can be reformulated as a least-squares minimization problem. Although the cost function is nonconvex, the global convergence of gradient descent algorithm from a random initialization is studied, when $m$ is large enough. We improve the known result of the local convergence from a spectral initialization. When the signal $\bm{x}$ is real-valued, we prove that the cost function is local convex near the solution $\{\pm\bm{x}\}$. To accelerate the gradient descent, we review and apply several efficient line search methods. We also perform a comparative numerical study of the line search methods and the alternative projection method. Numerical simulations demonstrate the superior ability of LBFGS algorithm than other algorithms.
HF radar ADC dynamic range requirements (1999)

This paper has examined the feasibility of excluding conventional receivers from HF radar receiving systems and feeding the amplified and filtered output of the receiving antenna directly to the ADC. Provided that adequate filtering is included in the signal path, the SFDR of current commercially available ADCs capable of sampling around 65 MHz (100 dB) determines that in excess of 99% of radar channels could be accommodated. All radar channels would be covered if the ADC SFDR were increased to 120 dB. On the basis of the above analysis it may be concluded that currently available ADC technology offers scope for the ADC to digitise the amplified signal from a HF antenna without the requirement of a conventional receiver. The repercussions for a 400-channel HF radar receiving system are clearly significant and warrant additional work, principally experimental verification. Specifically, digital data collected in accordance with the above requires analysis in order to demonstrate that the original external noise levels characterising clear radar channels have not been degraded to any significant extent by the proposed receiving system.
Characterization of the human lipoprotein lipase (LPL) promoter: evidence of two cis-regulatory regions, LP-alpha and LP-beta, of importance for the differentiation-linked induction of the LPL gene during adipogenesis. (1992)

When preadipocytes differentiate into adipocytes, several differentiation-linked genes are activated. Lipoprotein lipase (LPL) is one of the first genes induced during this process. To investigate early events in adipocyte development, we have focused on the transcriptional activation of the LPL gene. For this purpose, we have cloned and fused different parts of intragenic and flanking sequences with a chloramphenicol acetyltransferase reporter gene. Transient transfection experiments and DNase I hypersensitivity assays indicate that several positive as well as negative elements contribute to transcriptional regulation of the LPL gene. When reporter gene constructs were stably introduced into preadipocytes, we were able to monitor and compare the activation patterns of different promoter deletion mutants at selected time points representing the process of adipocyte development. We could delimit two cis-regulatory elements important for gradual activation of the LPL gene during adipocyte development in vitro. These elements, LP-alpha (-702 to -666) and LP-beta (-468 to -430), contain a striking similarity to a consensus sequence known to bind the transcription factors HNF-3 and fork head. Results of gel mobility shift assays and DNase I and exonuclease III in vitro protection assays indicate that factors with DNA-binding properties similar to those of the HNF-3/fork head family of transcription factors are present in adipocytes and interact with LP-alpha and LP-beta. We also demonstrate that LP-alpha and LP-beta were both capable of conferring a differentiation-linked expression pattern to a heterolog promoter, thus mimicking the expression of the endogenous LPL gene during adipocyte differentiation. These findings indicate that interactions with LP-alpha and LP-beta could be a part of a differentiation switch governing induction of the LPL gene during adipocyte differentiation.
Immune-response gene-associated antigens (Ia/DR). Structure and function in immunologically related diseases. (1983)

Major histocompatibility complex-determined antigens were originally identified as a consequence of their ability to induce rejection of tissue grafts between organisms that are not genetically identical. Currently, much is known about their biochemical nature and intended biological functions. Major histocompatibility complex antigens are found on three types of glycoprotein molecules. One type (class I) is associated with beta 2-microglobulin in the cell-surface membranes of all body tissues and includes H-2K and D molecules in mice and HLA-A, B, and C molecules in humans. These antigens are the major cause of rejection of transplanted organs. The other two types of glycoproteins (class II) are noncovalently linked to each other, are found in the cell-surface membranes of a limited number of cell types, and include H-2-Ia molecules in mice and HLA-DR molecules in humans. They are noted for their ability to elicit graft-versus-host disease. Both class I and class II molecules are, however, important for the immune recognition of pathogens, although the types of responses they modulate are different. Class I molecules are important in the recognition of cell-surface antigens, whereas class II molecules control responsiveness to soluble antigens. Major histcompatibility complex-encoded molecules are also involved in certain autoimmune diseases. As our understanding of major histocompatibility complex-controlled immune responsiveness broadens and hybridoma and gene-cloning technology advances, specific enhancement of desired immune responses and suppression of deleterious ones will most likely become possible.
In vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells (1997)

Camptothecin (CPT) is a specific topoisomerase I (top1) poison which traps top1 cleavable complexes; e.g. top1-linked DNA single-strand breaks with 5'-hydroxyl and 3'-top1 linked termini. CPT is also a potent anticancer agent and several of its derivatives have recently shown activity in the chemotherapy of solid tumors. Our aim was to apply the ligation-mediated polymerase chain reaction (LM-PCR) method to DNA extracted from CPT-treated cells in order to: (i) evaluate LM-PCR as a sensitive technique to detect in vivo CPT-induced cleavable complexes; (ii) investigate the frequency and distribution of CPT-induced DNA damage in vivo ; and (iii) compare the distribution and intensity of cleavage sites in vivo and in vitro. This report describes a protocol allowing the sequencing of top1-mediated DNA strand breaks induced by CPT in the coding strand of the 18S rRNA gene of human colon carcinoma cells. CPT or its clinical derivatives, topotecan, CPT-11, SN-38, and 9-aminocamptothecin differed in their potency and exhibited differences in their DNA cleavage pattern, which is consistent with our previous in vitro studies [Tanizawa et al . (1995) Biochemistry , 43, 7200-7206]. CPT-induced DNA cleavages induced in the presence of purified top1 were induced at the same sites in the human 18S rDNA. However, the relative intensity of the cleavages were different in vivo and in vitro. Because mammalian cells contain approximately 300 copies of the rDNA gene per genome, rDNA could be used to monitor CPT-induced DNA cleavage in different cell lines and possibly in tumor samples.