gebhart/patrepeval huggingface dataset:
Capping the electricity cost of cloud-scale data centers with impacts on power markets (2011)

In this paper, we propose a novel electricity cost capping algorithm that not only minimizes the electricity cost of operating cloud-scale data centers, but also enforces a cost budget on the monthly electricity bill. Our solution first explicitly models the impacts of power demands on electricity prices and the power consumption of cooling and networking in the minimization of electricity cost. In the second step, if the electricity cost exceeds a desired monthly budget due to unexpectedly high workloads, our solution guarantees the quality of service for premium customers and trades off the request throughput of ordinary customers. We formulate electricity cost capping as two related constrained optimization problems and propose an efficient algorithm based on mixed integer programming. Simulation results show that our solution outperforms the state-of-the-art solutions by having lower electricity costs and achieves desired cost capping with maximized request throughput.
Capacity of virulent Treponema pallidum (Nichols) for deoxyribonucleic acid synthesis (1979)

Treponema pallidum (Nichols) was extracted from infected rabbit tissue, and cell lysates were prepared for monitoring thymidine kinase and deoxyribonucleic acid polymerase activities. No thymidine kinase could be demonstrated in preparations of T. pallidum or the cultivable T. phagedenis biotype Reiter. Significant levels of deoxyribonucleic acid polymerase were detected in both treponemal samples. Interestingly, comparisons of polymerase activity among a spectrum of bacterial genera revealed a direct correlation between enzyme concentrations and estimated generation time. Incorporation of [3H]uridine and [3H]thymidine into macromolecules by intact T. pallidum and the Reiter treponeme was examined. Selective ribonuclease-deoxyribonuclease digestion and cesium chloride gradient banding demonstrated that T. pallidum, independent of the host, and T. phagedenis were capable of synthesizing deoxyribonucleic acid only from the [3H]-uridine precursor.
Development of Phosphorus-compound CaSo₄:Dy(KCT-300) TL Pellets (2002)

CaSO:Dy thermoluminescence dosimeter (TLD) is widely used as a personal or environmental dosimeter because of its high sensitivity to radiation. There are many methods to make pellets from the TL phosphorss[l-5]. Sintered pellets were made from a mixture of CaSO:Dy phosphor and Teflon powder is the most common method. But this method has disadvantage that CaSO:Dy pellet does not have very high sensitivity because of large amounts of Teflon in Pellets. This Paper described development of a new type of CaSO:Dy pellets by using P- compounds as a bonding material (KCT-300), and compared the TL sensitivity with that of the commercialized Teledyne CaSO: Dy pellets. Sensitivity of a new developed KCT-300 shows about 6 times than Teledyne ones, and can be used to measure very low radiation dose.
The Rapid Detection of Cefotaxime-Resistant <i>Enterobacteriaceae</i> by HPLC (2016)

This assay could be readily established in any clinical laboratory with an HPLC to rapidly detect ESBL-producing <i>Enterobacteriaceae</i>.
Point-of-care diagnostics: will the hurdles be overcome this time? (2006)

Point-of-care diagnostics have been proposed as the latest development in clinical diagnostics several times in the last 30 years; however, they have not yet fully developed into a business sector to match the projections. This perspective examines the reasons for past failures and the failure of technology to meet user needs. Advances have taken place in the last few years that effectively remove technology as a barrier to the development of point-of-care testing. Even regulatory issues regarding how products are developed and claims supported have been absorbed, understood and now accepted. The emphasis here is on the possible favorable aspects that are novel this time around. These changes have arisen as a result of the situation with global healthcare economics and the pressure from patients to be treated more like customers. The final hurdles relate to the conflict between diagnosis with the patient present and treated as soon as the point-of-care result is available and the entrenched positions of the central laboratory, the suppliers and their established distribution chains, and the way in which healthcare budgets are allocated. The ultimate hurdle that encapsulates all of these issues is reimbursement, which is the final barrier to a significant point-of-care diagnostics market--without reimbursement there will be no market.
Cytokinetic and biochemical effects of 5-iminodaunorubicin in human colon carcinoma in culture. (1982)

The semisynthetic anthracycline, 5-iminodaunorubicin (IM), was investigated to see whether modification of the benzoquinone moiety to produce a drug with low free radical potential would alter the cytotoxic and biochemical characteristics of this drug in comparison to Adriamycin (ADR), an agent with high free radical potential. Cell viability was measured in human colon carcinoma (HT-29) cells by soft-agar cloning. Upon exposure to either log-phase or early plateau-phase cells for 2 hr to IM or ADR, a threshold exponential cell lethality curve was obtained. Prolonging during exposure to 24 hr produced an exponential decline in cell survival and a marked reduction in viability of both log-phase and early plateau-phase cells. Inhibition of DNA synthesis in log-phase cells after 2 and 24 hr of exposure to IM and ADR paralleled the increased cell lethality produced by the drugs. In contrast, total RNA synthesis was not inhibited by IM, whereas ADR impaired both RNA and DNA synthesis. Nuclear rRNA, synthesis was not significantly inhibited following 24 hr of exposure to 10(-7) M ADR or IM but was inhibited by 85 and 35% at 10(-6) M ADR or IM, respectively. The affinity of IM and ADR for HT-29 DNA was measured in vitro by displacement of acridine orange binding and was found to be similar for both analogs. These studies suggest that the cytotoxicity of IM and ADR results from the interactions of these drugs with DNA.
Behavioural and histopathological alterations in mice with cerebral malaria (2006)

Different features of sensorimotor function and behaviour were studied in murine cerebral malaria (CM) and malaria without cerebral involvement (non-CM) applying the primary screen of the SHIRPA protocol. Histopathological analysis of distinct brain regions was performed and the relative size of haemorrhages and plugging of blood cells to brain vasculature was analysed. Animals suffering from CM develop a wide range of behavioural and functional alterations in the progressive course of the disease with a statistically significant impairment in all functional categories assessed 36 h prior to death when compared with control animals. Early functional indicators of cerebral phenotype are impairments in reflex and sensory system and in neuropsychiatric state. Deterioration in function is paralleled by the degree of histopathological changes with a statistically significant correlation between the SHIRPA score of CM animals and the mean size of brain haemorrhage. Furthermore, image analysis yielded that the relative area of the brain lesions was significantly larger in the forebrain and brainstem compared with the other regions of interest. Our results indicate that assessment of sensory and motor tasks by the SHIRPA primary screen is appropriate for the early in vivo discrimination of cerebral involvement in experimental murine malaria. Our findings also suggest a correlation between the degree of functional impairment and the size of the brain lesions as indicated by parenchymal haemorrhage. Applying the SHIRPA protocol in the functional characterization of animals suffering from CM might prove useful in the preclinical assessment of new antimalarial and potential neuroprotective therapies.
Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease (2008)

Substantial evidence from epidemiological, pathological, and clinical reports suggests that vascular factors are critical in the pathogenesis of Alzheimer's disease (AD), and changes in blood flow are currently the most reliable indicators of the disease. We previously reported that older APP23 transgenic (tg) mice have significant blood flow alterations correlated with structural modifications of blood vessels. For the present study, our objective was to analyze the age-dependent morphological and architectural changes of the cerebral vasculature of APP23 tg mice. To visualize the 3D arrangement of the entire brain vasculature, we used vascular corrosion casts. Already at young ages, when typically parenchymal amyloid plaques are not yet present, APP23 tg mice had significant alterations, particularly of the microvasculature, often accompanied by small deposits attached to the vessels. In older animals, vasculature abruptly ended at amyloid plaques, resulting in holes. Often, small deposits were sitting near or at the end of truncated vessels. Between such holes, the surrounding vascular array appeared more dense and showed features typical for angiogenesis. We propose that small amyloid aggregates associated with the microvasculature lead to morphological and architectural alterations of the vasculature, resulting in altered local blood flow. The characteristic early onset of vascular alterations suggests that imaging blood flow and/or vasculature architecture could be used as a tool for early diagnosis of the disease and to monitor therapies.
Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats (2006)

The effect of beta-cryptoxanthin, a kind of carotenoid, on ovariectomy-induced bone loss was investigated. beta-cryptoxanthin was isolated from Satsuma mandarin (Citrus unshu. MARC). beta-cryptoxanthin (5 or 10 microg/100 g body weight) was orally administered once daily for 3 months to ovariectomized (OVX) rats. OVX induced a significant increase in body weight and a significant decrease in serum calcium and inorganic phosphorus concentrations as compared with those of sham-operated (control) rats. These alterations induced by OVX were significantly prevented by the administration of beta-cryptoxanthin (5 or 10 microg/100 g). The analysis using a peripheral quantitative computed tomography (pQCT) showed that OVX induced a significant decrease in mineral content and mineral density in the femoral-diaphyseal and -metaphyseal tissues and polar strength strain index in the metaphyseal tissues. These decreases were significantly prevented by the administration of beta-cryptoxanthin (5 or 10 microg/100 g). Moreover, OVX induced a significant decrease in calcium content and alkaline phosphatase activity in the femoral-diaphyseal and -metaphyseal tissues and deoxyribonucleic acid (DNA) content in the metaphyseal tissues. These decreases were significantly prevented by the administration of beta-cryptoxanthin (5 or 10 microg/100 g). This study demonstrates that beta-cryptoxanthin has a preventive effect on OVX-induced bone loss in vivo.
Characterization of <i>Bacillus anthracis</i> iron‐regulated surface determinant (Isd) proteins containing NEAT domains (2008)

Three iron-regulated surface determinant (Isd) proteins, containing NEAr Transporter (NEAT) domains (GBAA4789-7), constitute part of an eight-member Bacillus anthracis operon. GBAA4789 (IsdC), previously characterized by others as a haem-binding protein, and two novel Isd proteins characterized in this study, GBAA4788 (IsdJ) and GBAA4787 (IsdK) proteins, can be translated from two alternative overlapping transcriptional units. The three NEAT-containing Isd proteins are shown to be expressed in vivo during B. anthracis infection. Expression in vitro is regulated by iron ions independent of the virulence plasmids pXO1 and pXO2, yet their presence affects the range of response to iron ion concentration. The expression of IsdC, J and K is strongly repressed under high CO(2) tension, conditions that are optimal for B. anthracis toxin and capsule expression, suggesting that these Isd proteins are elements of a B. anthracis'air-regulon'. Deletion mutants of isdC, isdK or the entire isdCJK locus are as virulent and pathogenic to guinea pigs as the fully virulent wild-type Vollum strain. The isdC-deleted mutant is defective in sequestration of haemin, consistent with previous biochemical observations, while the DeltaisdK mutant is defective in haemoglobin uptake. Studies with recombinant IsdK demonstrate specific binding to haemoglobin.
A UHF band 1.3 W monolithic amplifier with efficiency of 63% (2003)

A UHF-band 1.3-W high-efficiency, four-stage monolithic power amplifier with a novel miniaturized second-harmonic terminating circuit was developed. With the use of a parallel resonant circuit composed of lumped elements for terminating the second harmonic, it achieved a maximum drain efficiency of 63% and a saturated output power of higher than 31 dBm in the UHF band, and it occupied an area of 8.6*5.8 mm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A "quickscore" method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas. (1995)

Immunohistochemistry is increasingly used in the assessment of markers for breast cancer prognosis. Semiquantitation is frequently desirable but, other than by the use of image analysis, the approaches currently in use are cumbersome. The most common method used is the H-score which takes into consideration the staining intensity in conjunction with the percentage of cells staining positively in breast carcinoma tissue. A "quickscore" has been developed which dispenses with the need to count individual cells. The quantitative biochemical Abbott enzyme immunoassay (EIA) and the Dako immunohistochemical assay (IHA) incorporating a semiquantitative H-score, have been used as standards against which the IHA quickscore for the semiquantitation of oestrogen receptor expression was tested. A good correlation was found between the quickscore and the EIA, which was as good as that between the H-score and EIA. The quickscore is a valid approach and there is no advantage in using the more rigorous H-score. A positive cut off quickscore of > or = 3 has been suggested.
Molecular Sieve Studies of Interacting Protein Systems (1967)

Abstract The basic equations for molecular sieve behavior of associating systems are presented in detail. In this analysis equations are derived to describe elution boundaries for which axial dispersion of solute arises as a result of macromolecular interactions. The theory is developed as an extension of de Vault's basic approach to idealized column chromatography, but emphasizes the molecular sieve coefficient as a basic phenomenological transport parameter. By this approach, the partition isotherm for an interacting system of macromolecules is resolved into terms that represent linear isotherms of the individual components. Equations for elution profiles of associating systems are then derived in a convenient form in which the equilibrium constants for interactions among components are related to the corresponding transport coefficients of the individual molecular species. The theory has been formulated on the basis of a model sufficiently general to include isomeric forms for each degree of aggregation. The treatment is therefore applicable to equilibria that include (a) subunit association reactions, including the special case of monomer ⇌ n-mer interactions, (b) isomers that represent different geometric arrangements of subunits, and (c) isomeric states that are reversibly accessible to allosteric oligomers. A brief extension of the analysis is outlined to include the case of linearly concentration-dependent molecular sieve transport coefficients for each of the interacting species.
Atomic Structure and Dynamics of Self-Limiting Sub-Nanometer Pores in Monolayer WS<sub>2</sub> (2018)

We reveal a self-limiting mechanism during the formation of a specific type of circular nanopore in monolayer WS<sub>2</sub> that limits its diameter to sub-nm. A single W atom vacancy (triangular nanopore) is transformed into the self-limiting nanopore (SLNP) through the atomic restructuring of S atoms around the area, reducing the number of dangling bonds at the nanopore edge by shifting them further in-plane with W-W bonding instead. Bond rotations in WS<sub>2</sub> help accommodate the electron beam induced atomic loss and ensure the stability of the SLNP. The SLNP shows significant improvement in diameter stability during electron beam irradiation compared to other triangular nanopores in WS<sub>2</sub> that typically continue to expand in diameter during atom loss. The atomic structure of these SLNPs is studied using aberration-corrected scanning transmission electron microscopy with an in situ heating holder, revealing that the SLNPs are mostly formed at a temperature of ∼500 °C, which is a balance between thermally activated S vacancy diffusion and sufficient S vacancy density to initiate local atomic reconstruction. At higher temperatures ( i. e., 1000 °C), S vacancies quickly migrate away into long line vacancies, resulting in low S vacancy density and rapidly expanding holes generated at the edges of the line vacancies. At room temperature, S vacancy migration is low and vacancy density is very high, which limits atomic reconstruction, and instead many small holes open up. These results provide insights into the factors that lead to uniform sized nanopores in the sub-nm range in transition-metal dichalcogenides.
Increased Prevalence of Immunoglobulin A Deficiency in Patients with the Chromosome 22q11.2 Deletion Syndrome (DiGeorge Syndrome/Velocardiofacial Syndrome) (1998)

We wished to determine the prevalence of immunoglobulin A (IgA) deficiency in patients with the chromosome 22q11.2 deletion syndrome. A total of 32 patients with the chromosome 22q11.2 deletion were examined for IgA deficiency. We report a 13% (n = 4) prevalence of IgA deficiency in patients with this syndrome. The odds ratio of IgA deficiency in this population is 14.20 (P < 0.0001). This confirms the occurrence of significant humoral deficits in this predominantly cellular immunodeficiency.
EFFECT OF OPERATING CONDITIONS ON GAS HOLDUP IN SLURRY BUBBLE COLUMNS WITH A FOAMING LIQUID (1992)

Abstract This work presents experimental data on gas holdup in slurry bubble columns with a foaming liquid. The effects of solids concentration, solid particle size, superficial phase velocities and column dimensions on the gas holdup are analyzed. At low superficial gas velocities (less than 4cm/s), for which the liquid does not foam, the presence of solids with small particle size does not affect the gas holdup whereas solids with large particle size induce foam formation and thus their presence increases the gas holdup. In the foaming regime, an increase of solids concentration decreases the gas holdup. The operating mode has a strong effect on the gas holdup: the semi-batch operating mode (stagnant liquid-solid suspension) increases the ability of the liquid to foam with respect to the continuous mode. Regarding the effect of column dimensions, the results presented show that the height of the bubble column does not affect at an appreciable extent the gas holdup in the range 6 < LID < 12. At high gas velocities (greater than 6 cm/s) the gas holdups obtained in a 30 cm-internal diameter column are the same as those measured in a 10 cm-internal diameter column. KEYWORDS: Bubble columnFoamingGas holdupThree-phase Additional informationNotes on contributorsL. ANTONIO ESTÉVEZ Author to whom correspondence should be addressed A.E. SÁEZ Present address: Department of Chemical Engineering, University of Puerto Rico, Mayagiiez, Puerto Rico 00709-5000.
A 20W and broadband two-stage LDMOS power amplifier with high-Q Cu integrated passive device for multi-band and multi-standard applications (2016)

This paper presents a 20W and broadband power amplifier using high-Q Cu integrated passive device (IPD). Dual-path and two-stage broadband RFIC PA using the latest LDMOS technology covers from 1.5 GHz to 2.5 GHz frequency band and performs exceptionally well in multi-mode and multi-band operations. The measured power gain and drain efficiency in class-AB mode achieved more than 30 dB and between 18% and 22% from 1.8 GHz to 2.5 GHz at 10 dB power back-off, respectively. In order to validate the multi-band operation, the PA is linearized as the final stage of the low power line-up by the NXP DFE DPD system under 145 MHz 3C LTE signals and has more than 27% efficiency and -57 dBc corrected ACLR at the average output power of 36 dBm (8 dB back-off). To the best of the authors' knowledge, this is the first demonstration of broadband high power amplifier with excellent wideband DPD linearization and RF performance.
Blocking the apolipoprotein E/Amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology (2013)

Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late-onset Alzheimer's disease (AD). Studies have shown that the binding between apoE and amyloid-β (Aβ) peptides occurs at residues 244-272 of apoE and residues 12-28 of Aβ. ApoE4 has been implicated in promoting Aβ deposition and impairing clearance of Aβ. We hypothesized that blocking the apoE/Aβ interaction would serve as an effective new approach to AD therapy. We have previously shown that treatment with Aβ12-28P can reduce amyloid plaques in APP/PS1 transgenic (Tg) mice and vascular amyloid in TgSwDI mice with congophilic amyloid angiopathy. In the present study, we investigated whether the Aβ12-28P elicits a therapeutic effect on tau-related pathology in addition to amyloid pathology using old triple transgenic AD mice (3xTg, with PS1M146V , APPSwe and tauP30IL transgenes) with established pathology from the ages of 21 to 26 months. We show that treatment with Aβ12-28P substantially reduces tau pathology both immunohistochemically and biochemically, as well as reducing the amyloid burden and suppressing the activation of astrocytes and microglia. These affects correlate with a behavioral amelioration in the treated Tg mice.
A combined SIFT/SURF descriptor for automatic face recognition (2013)

This paper deals with Automatic Face Recognition (AFR). A novel approach which combines the SIFT and SURF features for the face representation is proposed. The obtained combined SIFT/SURF descriptor is then used for face comparison by the adapted Kepenekci matching method. The proposed method is evaluated on the FERET and CTK corpora. The obtained recognition rates are 98.4% and 64.6% respectively. These recognition scores show that our approach outperforms significantly all other methods on these corpora. The differences between recognition error rates of the proposed approach and the second best one are 41% and 7% in relative value respectively.
Syntheses of Vinylogous 4H-Pyrones from 2,6-Dimethyl-4H-pyran-4-thione and Arenyl Bromomethyl Ketones (1986)

La reaction des composes du titre conduit aux bromures de dimethyl-2,6 aroylmethylthio-4 pyryliums; leur desulfuration par le DBU conduit aux aroylmethylene-4 dimethyl-2,6 4H-pyrannes
Optoelectronic buses for high-performance computing (1994)

Modern computer buses are typically organized by the three functions of data transfer, addressing, and arbitration/control. In this paper we present a fiber-based bus design which provides optical solutions for each of these functions. The design includes an all-optical addressing system, based on coincident pulse addressing, which eliminates the latency contribution and bandwidth limitation associated with electronic address decoding. The control system uses time-of-flight relationships between a priority chain and a feedback waveguide to implement fully distributed asynchronous and self-timed bus arbitration.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>