gebhart/patrepeval huggingface dataset:
Inhibition of GSK‐3β activity attenuates proliferation of human colon cancer cells in rodents (2007)

The authors' recent discovery that glycogen synthase kinase-3beta (GSK-3beta) participates in colon cancer cells' survival and proliferation prompted us to investigate whether GSK-3beta inhibition alters proliferation of colon cancer cells in vivo. Groups of four or five athymic mice (Balb/c, nu/nu) with subcutaneous xenografts of SW480 human colon cancer cells were treated with dimethyl sulfoxide (DMSO) or different doses (1, 2 and 5 mg/kg body weight) of either small-molecule GSK-3beta inhibitor (SB-216763 and AR-A014418) by intraperitoneal injection three times per week for 5 weeks. Compared with DMSO (a diluent of the GSK-3beta inhibitors) as a control, either GSK-3beta inhibitor significantly inhibited proliferation of cancer cell xenografts in the rodents in a dose-dependent manner. Histochemical and immunohistochemical analysis of tumor xenografts demonstrated a significant, dose-dependent decrease in fractions of proliferating cells and an increase in the incidence of apoptosis of cancer cells in mice treated with either GSK-3beta inhibitor. No adverse events or effects were observed in the rodents during the course of treatment, except for rare lethal accidents due to intraperitoneal injection. Morphological examination showed no apparent pathologic changes in major organs including the lungs, liver, pancreas, kidneys, spleen and large bowel of rodents treated with DMSO and the GSK-3beta inhibitors. The results indicate that the GSK-3beta inhibitors would be a novel class of therapeutic agent for colon cancer.
Aspheric and freeform surfaces metrology with software configurable optical test system: a computerized reverse Hartmann test (2013)

A software configurable optical test system (SCOTS) based on deflectometry was developed at the University of Arizona for rapidly, robustly, and accurately measuring precision aspheric and freeform surfaces. SCOTS uses a camera with an external stop to realize a Hartmann test in reverse. With the external camera stop as the reference, a coordinate measuring machine can be used to calibrate the SCOTS test geometry to a high accuracy. Systematic errors from the camera are carefully investigated and controlled. Camera pupil imaging aberration is removed with the external aperture stop. Imaging aberration and other inherent errors are suppressed with an N -rotation test. The performance of the SCOTS test is demonstrated with the measurement results from a 5-m-diameter Large Synoptic Survey Telescope tertiary mirror and an 8.4-m diameter Giant Magellan Telescope primary mirror. The results show that SCOTS can be used as a large-dynamic-range, high-precision, and non-null test method for precision aspheric and freeform surfaces. The SCOTS test can achieve measurement accuracy comparable to traditional interferometric tests.
Dose-Related Effects of Prolonged NaHCO3 Ingestion during High-Intensity Exercise (2006)

NaHCO3 administration for 5 d may prevent acid-base balance disturbances and improve performance during anaerobic exercise in a dose-dependent manner.
Structure and function of murine alphaIIbbeta3 (GPIIb/IIIa): studies using monoclonal antibodies and beta3-null mice,. (2000)

The alphaIIbeta3 receptor (GPIIb/IIIa) is the only platelet-specific integrin receptor and the most abundant adhesion/aggregation receptor on the surface of human platelets. Since mice are increasingly being used as models of human disease, we analyzed the structure and function of murine platelet alphaIIbeta3, utilizing both beta3 integrin-deficient mice, who have a phenotype that resembles Glanzmann thrombasthenia, and our hamster monoclonal antibody (mAb) 1B5 to murine alphaIIbbeta3. By immunoblot analysis, flow cytometry, and mAb binding studies, mouse platelets express abundant amounts of alphaIIbbeta3 (60-80,000 copies/platelet). Like their human counterparts, murine alphaIIb and beta3 exhibit different electrophoretic motilities under nonreducing (aIIb 135k Da; beta3 92k Da) and reducing (aIIb 120k Da; beta3 108k Da) conditions, and the alphaIIbbeta3 complex is dissociated by EDTA at pH 8 and 37 degrees C. Murine beta3 is less susceptible to proteolysis by plasmin than is human beta3. In addition to defective platelet aggregation, mouse platelets lacking alphaIIbbeta3 and alphaVbeta3 are unable to adhere to fibrinogen and prothrombin, but retain the ability to adhere to fibronectin and collagen. Following platelet activation, beta3-null platelets express slightly less P-selectin than do wild-type mouse platelets. Moreover, beta3-null platelets have altered tyrosine phosphorylation patterns following thrombin- and collagen-induced aggregation. These results suggest fundamental similarities between human and mouse platelet activation and aggregation, but delineate subtle differences that need to be considered when comparing studies from mice and humans.
HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma (2016)

These results provide evidence for a novel role of HDACs in modulating T-cell chemokine expression in multiple cell types. In addition, our findings indicate that pharmacologic induction of T-cell chemokine expression represents a conceptually novel approach for enhancing immunotherapy response. Finally, these results suggest that combination of HDAC inhibitors with PD-1 blockade represents a promising strategy for lung cancer treatment. Clin Cancer Res; 22(16); 4119-32. ©2016 AACR.
Electronegativity and Lewis acid strength (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronegativity and Lewis acid strengthI. D. Brown and A. SkowronCite this: J. Am. Chem. Soc. 1990, 112, 9, 3401–3403Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/ja00165a023https://doi.org/10.1021/ja00165a023research-articleACS PublicationsRequest reuse permissionsArticle Views4339Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High Per formance and Flexible Supercapacitors based on Carbonized Bamboo Fibers for Wide Temperature Applications (2016)

High performance carbonized bamboo fibers were synthesized for a wide range of temperature dependent energy storage applications. The structural and electrochemical properties of the carbonized bamboo fibers were studied for flexible supercapacitor applications. The galvanostatic charge-discharge studies on carbonized fibers exhibited specific capacity of ~510F/g at 0.4 A/g with energy density of 54 Wh/kg. Interestingly, the carbonized bamboo fibers displayed excellent charge storage stability without any appreciable degradation in charge storage capacity over 5,000 charge-discharge cycles. The symmetrical supercapacitor device fabricated using these carbonized bamboo fibers exhibited an areal capacitance of ~1.55 F/cm(2) at room temperature. In addition to high charge storage capacity and cyclic stability, the device showed excellent flexibility without any degradation to charge storage capacity on bending the electrode. The performance of the supercapacitor device exhibited ~65% improvement at 70 °C compare to that at 10 °C. Our studies suggest that carbonized bamboo fibers are promising candidates for stable, high performance and flexible supercapacitor devices.
Convolutional neural networks for human activity recognition using multiple accelerometer and gyroscope sensors (2016)

Human activity recognition involves classifying times series data, measured at inertial sensors such as accelerometers or gyroscopes, into one of pre-defined actions. Recently, convolutional neural network (CNN) has established itself as a powerful technique for human activity recognition, where convolution and pooling operations are applied along the temporal dimension of sensor signals. In most of existing work, 1D convolution operation is applied to individual univariate time series, while multi-sensors or multi-modality yield multivariate time series. 2D convolution and pooling operations are applied to multivariate time series, in order to capture local dependency along both temporal and spatial domains for uni-modal data, so that it achieves high performance with less number of parameters compared to 1D operation. However for multi-modal data existing CNNs with 2D operation handle different modalities in the same way, which cause interferences between characteristics from different modalities. In this paper, we present CNNs (CNN-pf and CNN-pff), especially CNN-pff, for multi-modal data. We employ both partial weight sharing and full weight sharing for our CNN models in such a way that modality-specific characteristics as well as common characteristics across modalities are learned from multi-modal (or multi-sensor) data and are eventually aggregated in upper layers. Experiments on benchmark datasets demonstrate the high performance of our CNN models, compared to state of the arts methods.
The role of neuromuscular electrical stimulation in the rehabilitation of the pelvic floor muscles (2019)

Pelvic floor dysfunction is a common problem, particularly for women. A weakness in the pelvic floor muscles can lead to one or more disorders developing, such as urinary incontinence or a pelvic organ prolapse. To combat this, it is advised that the pelvic floor muscles are exercised to strengthen them and help them become more supportive. However, more than 30% of women are unable to detect their pelvic floor muscles to produce an effective contraction. The introduction of neuromuscular electrical stimulation (NMES) in pelvic healthcare poses a significant benefit in the rehabilitation of the pelvic floor muscles.
Space‐based remote imaging spectroscopy of the Aliso Canyon CH<sub>4</sub> superemitter (2016)

Abstract The Aliso Canyon gas storage facility near Porter Ranch, California, produced a large accidental CH 4 release from October 2015 to February 2016. The Hyperion imaging spectrometer on board the EO‐1 satellite successfully detected this event, achieving the first orbital attribution of CH 4 to a single anthropogenic superemitter. Hyperion measured shortwave infrared signatures of CH 4 near 2.3 μm at 0.01 μm spectral resolution and 30 m spatial resolution. It detected the plume on three overpasses, mapping its magnitude and morphology. These orbital observations were consistent with measurements by airborne instruments. We evaluate Hyperion instrument performance, draw implications for future orbital instruments, and extrapolate the potential for a global survey of CH 4 superemitters.
Efficient nonlinear model predictive control (2000)

The growing interest in model predictive control for nonlinear systems is motivated by the fact that today&apos;s processes need to be operated under tighter performance specifications to guarantee profitable and environmentally safe production. Nonlinear model predictive control (NMPC) does allow the direct consideration of a nonlinear process model as well as state and input constraints. Thus NMPC seems to be well suited for these kind of processes. Many theoretical issues in NMPC have been attacked and solved in recent years. Despite this progress there are a number of problems that have to be solved before NMPC can be applied in practice.
The effect of adjuvants on immune function in the multi-low-dose streptozotocin model of murine diabetes. (1988)

The effect of various adjuvants has been investigated on the multi-low-dose (mld) streptozotocin (STZ) model of diabetes in C57BL/6 and CBA mice; diabetes was severe in the former strain. Diabetic levels of glycaemia were not attained in either strain using half the mld STZ dose (sub-mld-STZ). The adjuvants were found to affect the levels of glycaemia variously. Thus, in C57BL/6 mice at mld-STZ, CFA and saponin had no effect, whereas MDP and LPS respectively decreased and increased glycaemia; at sub-mld-STZ, each of the adjuvants increased glycaemia. In CBA mice, at both mld- and sub-mld-STZ, CFA and saponin increased glycaemia; at mld-STZ, MDP caused an initial increase but a later decrease in glycaemia, whereas with sub-mld-STZ only a decrease in glycaemia occurred; at mld-STZ, LPS was toxic in this strain, and had no effect on glycaemia at sub-mld-STZ. In both C57BL/6 and CBA mice, STZ caused a decrease in both spontaneous and PHA-stimulated blastogenesis. This persisted until day 14 in the C57BL/6 strain and until day 28 in the CBA strain. CFA reversed the anergy by day 7 in C57BL/6 mice and by day 14 in CBA mice, but did not improve beta-cell function, since further increments in glycaemia followed, except in mld-STZ C57BL/6 mice. Islet-cell surface antibodies (ICSAs) and cytotoxic islet-cell antibodies (CxICAs) occurred in both strains of mouse. ICSAs were persistent (still present at day 67), but CxICAs were detected only until day 23. The presence of ICSAs and CxICAs during the development of the diabetic state, and of ICSAs during its perpetuation, suggests that they may have a role in its aetiopathology. The lack of a correlation of non-specific T-cell anergy with glycaemia does not exclude a role for antigen-specific T-cell pathogenic processes.
Chitra: visual analysis of parallel and distributed programs in the time, event, and frequency domains (1992)

Chitra analyzes a program execution sequence (PES) collected during execution of a program and produces a homogeneous, semi-Markov chain model fitting the PES. The PES represents the evolution of a program state vector in time. Therefore Chitra analyzes the time-dependent behavior of a program. The authors describe a set of transforms that map a PES to a simplified PES. Because the transforms are program-independent. Chitra can be used with any program. Chitra provides a visualization of PESs and transforms, to allow a user to visually guide transform selection in an effort to generate a simple yet accurate semi-Markov chain model. The resultant chain can predict performance at program parameters different than those used in the input PES, and the chain structure can diagnose performance problems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Bistability and Differential Gain in Semiconductor Lasers (1982)

Bistable operation and differential gain characteristic have been achieved in the current-light output characteristics for stripe geometry InGaAsP/InP DH lasers with an inhomogeneous excitation. This device has an advantage in that the characteristics can be chosen merely by varying the stripe geometry and tuning the device temperature. Under the operating condition of bistability, switching between the two states was accomplished by applying an electrical pulse of 2.5 mA or less to the device. Switch-on time was less than 0.5 ns and switch-off time was about 1 ns. Bistable operation by optical injection is also reported. An incident optical beam, generated by a conventional DH semiconductor laser, was injected into the bistable laser. Bistability has been achieved in incident beam intensity-optical output intensity curves. The bistable laser also acted as an optical limiter.
Microdialysis Assessment of Fibrin Glue Containing Sodium Alginate for Local Delivery of Doxorubicin in Tumor-Bearing Rats. (1997)

This study was designed to assess a local drug delivery system of an anticancer agent, doxorubicin (DOX), using fibrin glue (Beriplast P) as a drug carrier. In vitro release of DOX from the fibrin glue was examined by a dialysis method in the presence and absence of sodium alginate. The in vitro mean dissolution times of DOX with solution, fibrin glue, and fibrin glue containing sodium alginate were 3.7 h, 8.7 h, and 81 h, respectively, indicating a sustained release of DOX from fibrin glue, especially in the presence of sodium alginate. Fibrin glue containing 6 mg of DOX and 2.5 mg of sodium alginate was applied on the surface of an AH60C tumor at the back of rats. DOX concentrations in the tumor extracellular fluid were monitored by a microdialysis method. Local application of DOX using fibrin glue containing sodium alginate to the tumor resulted in extremely higher concentrations in the tumor extracellular fluid than those in plasma (AUC ratio > 800), indicating an advantage of the site-specific delivery of DOX using fibrin glue with sodium alginate. The tumor volumes were inversely correlated with tumor extracellular fluid-to-plasma AUC ratios (r = 0.882), suggesting the relevance of tumor size in the drug efflux from tumor to blood. In conclusion, the site-specific delivery of DOX using fibrin glue with sodium alginate to the tumor was demonstrated to be advantageous with regard to the extent and duration of drug concentrations in the tumor extracellular fluid, as assessed by a microdialysis technique.
Emerging Role of Organ‐on‐a‐Chip Technologies in Quantitative Clinical Pharmacology Evaluation (2019)

The recently enacted Prescription Drug User Fee Act (PDUFA) VI includes in its performance goals "enhancing regulatory science and expediting drug development." The key elements in "enhancing regulatory decision tools to support drug development and review" include "advancing model-informed drug development (MIDD)." This paper describes (i) the US Food and Drug Administration (FDA) Office of Clinical Pharmacology's continuing efforts in developing quantitative clinical pharmacology models (disease, drug, and clinical trial models) to advance MIDD, (ii) how emerging novel tools, such as organ-on-a-chip technologies or microphysiological systems, can provide new insights into physiology and disease mechanisms, biomarker identification and evaluation, and elucidation of mechanisms of adverse drug reactions, and (iii) how the single organ or linked organ microphysiological systems can provide critical system parameters for improved physiologically-based pharmacokinetic and pharmacodynamic evaluations. Continuous public-private partnerships are critical to advance this field and in the application of these new technologies in drug development and regulatory review.
sn-l, 2-Diacylglycerols mimic the effects of 12-<i>0</i>-tetradecanoylphorbol-13-acetate <i>in vivo</i> by inducing biochemical changes associated with tumor promotion in mouse epidermis (1986)

12-O-Tetradecanoylphorbol-13 acetate (TPA) or various acylglycerols were applied topically to CD-1 mice, and biochemical changes associated with tumor promotion in the epidermis were examined. The topical application of 5 mumol of sn-1,2-didecanoylglycerol caused a 40-fold increase in ornithine decarboxylase activity which was similar to that found after the topical application of 2 nmol of TPA. The time course for the induction of ornithine decarboxylase activity by TPA and the time course for its induction by sn-1,2-didecanoylglycerol were similar; both compounds produced rapid increases in ornithine decarboxylase activity with peak induction occurring 4-6 h after application of the inducing chemical. sn-1,2-Dioctanoylglycerol and sn-1-oleoyl-2-acetylglycerol also increased ornithine decarboxylase activity in mouse epidermis, but sn-1,2-dioleoylglycerol, 1,3-didecanoylglycerol and rac-1-monodecanoylglycerol were inactive at the dose tested. trans-Retinoic acid, a potent inhibitor of tumor promotion, markedly inhibited the epidermal induction of ornithine decarboxylase activity that resulted from the topical administration of sn-1,2-didecanoylglycerol or TPA. The effects of TPA and the acylglycerols on epidermal DNA synthesis in vivo were determined by measuring the incorporation of [3H]thymidine into epidermal DNA. The application of sn-1,2-didecanoylglycerol or TPA to mouse skin stimulated epidermal DNA synthesis. The maximum increase occurred 18 h after administration of the inducing chemical, and the increase in DNA synthesis was proportional to the dose of sn-1,2-didecanoylglycerol. Although sn-1,2-didecanoylglycerol, sn-1,2-dioctanoylglycerol and sn-1,2-dioleoylglycerol stimulated epidermal DNA synthesis, sn-1-oleoyl-2-acetylglycerol, 1,3-didecanoylglycerol and rac-1-monodecanoylglycerol had little or no effect. The increase in epidermal DNA synthesis induced by sn-1,2-didecanoylglycerol or TPA was inhibited by the simultaneous application of fluocinolone acetonide, a potent inhibitor of tumor promotion. The results indicate that several sn-1,2-diacylglycerols mimic TPA in vivo with respect to their effects on certain biochemical parameters associated with tumor promotion in mouse skin.
Delayed menarche in homozygous sickle cell disease. (1986)

On constate que l'âge de la premiere menstruation chez les adolescents atteints d'anemie a hematie falciforme est retarde de 3-4 ans. Le retard de la premiere menstruation serait associe a un faible taux d'hemoglobine fœtale (p<0,001) a un faible taux d'hemoglobine totale (p<0,05) a un faible volume cellulaire moyen (p<0,05) a un faible poids (p<0,05) a une petite taille (p<0,01) et a un pauvre statut socioeconomique (p<0,05)
A Recursive Formula of A Participating Contract Embedding A Surrender Option (2008)

Bacinello (2003a) employed CRR model to numerically calculate the fair value of a participating policy containing a surrender option. Bacinello assumed a constant rate of return on risk-free assets. However, this study proposes a two-dimensional CRR model in a stochastic interest rate model as a means of providing a numerical method for contract pricing. The two-dimensional CRR model converges rapidly and achieves similar results to Monte Carlo simulation. Two-dimensional CRR models are used to analyze the importance and sensitivity of a stochastic interest rate model for the policy. Zero coupon bond volatility is an essential parameter in the surrender option, and reference portfolio volatility is important for pricing the participating option. The participating and surrender options are more valuable given upwards trending interest rates than constant or downwards trending rates.

Key words: Participating Policy, participating Option, surrender Option, two-dimensional CRR Model
Planar waveguide, 1 kW cw, carbon dioxide laser excited by a single transverse rf discharge (1992)

A transverse radio frequency discharge excited, carbon dioxide slab laser has been operated cw with a hybrid waveguide / confocal unstable resonator to produce an output power of 1.06 kW at 12% efficiency. The active volume of 770×95×2 mm3 consists of a single discharge section with one cable feed.
Generation of 20-fs pulses by a prismless Cr^4+:YAG laser (2002)

Ultrafast optical pulses shorter than 20 fs with 400-mW average power at a 110-MHz repetition rate have been generated by a Cr(4+):YAG laser with only double-chirped mirrors for dispersion compensation. The corresponding pulse spectrum has a peak intensity at 1450 nm and extends from 1310 to 1500 nm full width at half-maximum (FWHM). These pulses, which are believed to be the shortest generated to date from a Cr(4+):YAG laser, are only four optical cycles within the FWHM intensity width.