gebhart/patrepeval huggingface dataset:
Effect of preoperative autologous blood donation and intraoperative and postoperative blood recovery on homologous blood transfusion requirement in cementless total hip replacement operation. (1995)

The data from this study were similar to previously published reports. Regression analysis confirmed the correlation among the different variables studied. We currently offer preoperative donation and intraoperative salvage with the Cell Saver to patients undergoing cementless total hip replacement.
Modular Synthesis of Triazole‐Containing Triaryl α‐Helix Mimetics (2011)

Abstract We describe novel scaffold designs for nonpeptidic α‐helix mimetics. The tricyclic scaffolds contain triazoles and reproduce amino acid side chains i , i +3, and i +7. The three different scaffolds are synthetically readily accessible, allow the introduction of further substituents to increase the versatility, and are suitable for library design. A modular synthesis route using Cu I ‐ and Ru II ‐catalyzed azide–alkyne [3+2] cycloadditions as central steps was developed. To demonstrate the methodology, we have prepared a library of compounds containing all three scaffolds.
Adaptive cancellation ofmultiple interfering sinusoids (1998)

The adaptive sinusoidal interference canceller (ASIC) is a least-mean-square (LMS)-style algorithm for eliminating a sinewave of known frequency from an observed signal. The ASIC is generalised to cancel multiple interfering sinusoids. The performance of the algorithm, particularly when the interference frequencies are not exactly known, is analysed. It is also shown that the ASIC can provide a significant improvement in the signal-to-noise ratio.
Photocross-linking of nascent chains to the STT3 subunit of the oligosaccharyltransferase complex (2003)

In eukaryotic cells, polypeptides are N glycosylated after passing through the membrane of the ER into the ER lumen. This modification is effected cotranslationally by the multimeric oligosaccharyltransferase (OST) enzyme. Here, we report the first cross-linking of an OST subunit to a nascent chain that is undergoing translocation through, or integration into, the ER membrane. A photoreactive probe was incorporated into a nascent chain using a modified Lys-tRNA and was positioned in a cryptic glycosylation site (-Q-K-T- instead of -N-K-T-) in the nascent chain. When translocation intermediates with nascent chains of increasing length were irradiated, nascent chain photocross-linking to translocon components, Sec61alpha and TRAM, was replaced by efficient photocross-linking solely to a protein identified by immunoprecipitation as the STT3 subunit of the OST. No cross-linking was observed in the absence of a cryptic sequence or in the presence of a competitive peptide substrate of the OST. As no significant nascent chain photocross-linking to other OST subunits was detected in these fully assembled translocation and integration intermediates, our results strongly indicate that the nascent chain portion of the OST active site is located in STT3.
Minimization of Torque Ripple in Brushless DC Motor Drives (1986)

Torque characteristics of brushless dc motors are studied in terms of the EMF and the feed currents for two feeding schemes: two-phase feeding and three-phase feeding. Various techniques for minimizing torque ripple are considered and discussed. For three-phase feeding systems, a selective harmonics elimination technique is studied and its effectiveness is evaluated.
Efficient vectors for expression cloning of large numbers of PCR fragments in <i>P. pastoris</i> (2010)

The yeast vectors described, pYEV and pYEVB, were designed for parallel polymerase chain reaction (PCR) cloning of open reading frames (ORFs) and immediate protein expression in Pichia pastoris. The pYEV vector was used to clone PCR fragments obtained by using Taq or similar polymerase mixes, which leave an A-base overhang. The other vector pYEVB, with the same features for blunt-end ligation of PCR products, was developed to be complementary to pYEV. These two plasmids were linearized using the restriction enzymes BfuI and SchI, respectively. The purified PCR products, without any other treatments, were cloned into the linearized vectors, followed by selection on plates supplemented with X-gal. Only desired recombinants carrying the target gene in the correct orientation can give typical blue colonies. This screening technique is based on a lacO reconstruction strategy that can produce a full-length lacO to exhaust endogenous LacI and switch on the transcription of lacZ in the host. The recombinant plasmids extracted from the blue colonies can be linearized by SalI and transformed into P. pastoris for immediate expression. By using these two vectors, researchers could be saved from the tedious and time-consuming conventional cloning procedures.
Health Monitoring for a Structure Using Its Nonstationary Vibration (2010)

The frequency distribution of a short interval period, the SIP distribution, obtained from the vibration of a structure that is excited by the force of non‐stationary vibration is available for the robust estimation of the dynamic property of the structure. This paper shows experiments of the health monitoring of a model structure using the SIP distribution. Comparisons of SIP distributions with average DFT spectra are also shown.
Production of Insulating Board from Cornstalks (1930)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProduction of Insulating Board from CornstalksC. E. HartfordCite this: Ind. Eng. Chem. 1930, 22, 12, 1280–1284Publication Date (Print):December 1, 1930Publication History Published online1 May 2002Published inissue 1 December 1930https://doi.org/10.1021/ie50252a010RIGHTS & PERMISSIONSArticle Views24Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (824 KB) Get e-Alerts
Phase I study of TZT‐1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, given weekly to advanced solid tumor patients for 3 weeks (2008)

TZT-1027 is a novel synthetic dolastatin 10 derivative that inhibits tubulin polymerization. A phase I study was conducted to determine the maximum tolerated dose (MTD) of TZT-1027, and to assess its pharmacokinetic profile in Japanese patients with advanced solid tumors following administration of the drug weekly for 3 weeks. Eligible patients had advanced solid tumors that failed to respond to standard therapy or for which no standard therapy was available, and met the following criteria: performance status ≤2 and acceptable organ function. The MTD was defined as the highest dose at which more than two-thirds of the patients experienced grade 4 hematological toxicity or grade 3/4 non-hematological toxicity during weekly TZT-1027 administration for 3 weeks. Forty patients were enrolled in the present study. Twelve doses between 0.3 and 2.1 mg/m2 were evaluated. Grade 4 neutropenia was the principal dose-limiting toxicity (DLT). At a dose of 2.1 mg/m2, two patients developed DLT: one patient developed grade 4 neutropenia, grade 3 myalgia, and grade 4 constipation, and the other one developed grade 4 neutropenia and grade 3 constipation. At a dose level of 1.8 mg/m2, toxicity was acceptable and no DLT was observed. The area under the curve and maximum concentration of TZT-1027 tended to increase linearly with the dose. The DLT observed were neutropenia, myalgia, and constipation, and the MTD was 2.1 mg/m2. The recommended dose for a phase II study was determined to be 1.8 mg/m2 for the drug administered weekly for 3 weeks.
Extracting regulatory sites from the upstream region of yeast genes by computational analysis of oligonucleotide frequencies (1998)

We present here a simple and fast method allowing the isolation of DNA binding sites for transcription factors from families of coregulated genes, with results illustrated in Saccharomyces cerevisiae. Although conceptually simple, the algorithm proved efficient for extracting, from most of the yeast regulatory families analyzed, the upstream regulatory sequences which had been previously found by experimental analysis. Furthermore, putative new regulatory sites are predicted within upstream regions of several regulons. The method is based on the detection of over-rep-resented oligonucleotides. A specificity of this approach is to define the statistical significance of a site based on tables of oligonucleotide frequen-cies observed in all non-coding sequences from the yeast genome. In con-trast with heuristic methods, this oligonucleotide analysis is rigorous and exhaustive. Its range of detection is however limited to relatively simple patterns: short motifs with a highly conserved core. These features seem to be shared by a good number of regulatory sites in yeast. This, and similar methods, should be increasingly required to identify unknown regulatory elements within the numerous new coregulated families resulting from measurements of gene expression levels at the genomic scale. All tools described here are available on the web at the site
The “Q disease” in Superconducting Niobium RF Cavities (2003)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. Knobloch; The "Q disease" in Superconducting Niobium RF Cavities. AIP Conf. Proc. 11 July 2003; 671 (1): 133–150. https://doi.org/10.1063/1.1597364 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Simple radix-4 division with operands scaling (1990)

A radix-4 division algorithm with operands scaling is proposed. The algorithm uses a recurrence with redundant addition (carry-save or signed-digit) and combines simple scaling with a quotient-selection function that depends only on the estimate of the partial remainder and is independent of the divisor. The scheme results in a significant speedup with respect to both the radix-2 and radix-4 without scaling.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Design Support Methodology for District Metering of Water Supply Networks (2011)

Water District Metering (WDM) is one of the most efficient techniques for water loss detection and pressure management and consists in partitioning a water network into subsystems called District Meter Areas (DMA).The division of the network in hydraulically independent districts can be obtained by installing flow meters and boundary valves. Pipe closure can compromise original water system performance because it reduces the network reliability. When water systems are already in operation it is more difficult to set the number and dimension of districts and, in practical applications, the WDM design is generally based on empirical approaches or on limited field experiences. In this work an original approach to define the Water District Metering, based on graph theory principles, is put forward. The methodology proposed, arranged in a Design Support Methodology (DSM), allows to choose the position of flow meters and of boundary valves needed to define permanent DMAs using graph visualization of water network, minimum dissipated power paths and different performance indices based also on resilience concept. The DSM is tested on two case studies allowing to get rapidly good DMA layouts compatible with the level of service of water systems.
Covalent Modification of Gaseous Peptide Ions with <i>N</i>-Hydroxysuccinimide Ester Reagent Ions (2010)

Covalent modification of primary amine groups in multiply protonated or deprotonated polypeptides in the gas phase via ion/ion reactions is demonstrated using N-hydroxysuccinimide (NHS) esters as the modifying reagents. During the ion/ion reaction, the peptide analyte ions and the NHS or sulfo-NHS based reagent form a long-lived complex, which is a prerequisite for the covalent modification chemistry to occur. Ion activation of the peptide-reagent complex results in a neutral NHS or sulfo-NHS molecule loss, which is a characteristic signature of covalent modification. As the NHS or sulfo-NHS group leaves, an amide bond is formed between a free, unprotonated, primary amine group of a lysine side chain in the peptide and the carboxyl group in the reagent. Subsequent activation of the NHS or sulfo-NHS loss product ions results in sequence informative fragment ions containing the modification. The N-terminus primary amine group does not make a significant contribution to the modification process; this behavior has also been observed in solution phase reactions. The ability to covalently modify primary amine groups in the gas phase with N-hydroxysuccinimide reagents opens up the possibility of attaching a wide range of chemical groups to gaseous peptides and proteins and also for selectively modifying other analytes containing free primary amine groups.
Two Phenanthraquinones from <i>Dendrobium </i><i>m</i><i>oniliforme</i> (2001)

Two phenanthraquinones were isolated from the stems of Dendrobium moniliforme. They were identified by interpretation of spectral data as 2,6-dimethoxy-1,4,5,8-phenanthradiquinone and 5-hydroxy-3,7-dimethoxy-1,4-phenanthraquinone, named moniliformin (1) and denbinobin (2), respectively. This is the first report of compound 1, which possesses a novel 1,4,5,8-diquinone moiety in the phenanthraquinone skeleton. Compound 2 showed potent antiinflammatory effects in vitro.
Seaweed and Seaweed Bioactives for Mitigation of Enteric Methane: Challenges and Opportunities (2020)

Seaweeds contain a myriad of nutrients and bioactives including proteins, carbohydrates and to a lesser extent lipids as well as small molecules including peptides, saponins, alkaloids and pigments. The bioactive bromoform found in the red seaweed <i>Asparagopsis taxiformis</i> has been identified as an agent that can reduce enteric CH<sub>4</sub> production from livestock significantly. However, sustainable supply of this seaweed is a problem and there are some concerns over its sustainable production and potential negative environmental impacts on the ozone layer and the health impacts of bromoform. This review collates information on seaweeds and seaweed bioactives and the documented impact on CH<sub>4</sub> emissions in vitro and in vivo as well as associated environmental, economic and health impacts.
ChemInform Abstract: Radical Reactions Leading to Substituted Pyroglutamates. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Serotype Identification of Avian Infectious Bronchitis Virus by RT-PCR of the Peplomer (S-1) Gene (1998)

Calvin L. Keeler, Jr., Karen L. Reed, W. Allan Nix, Jack Gelb, Jr., Serotype Identification of Avian Infectious Bronchitis Virus by RT-PCR of the Peplomer (S-1) Gene, Avian Diseases, Vol. 42, No. 2 (Apr. - Jun., 1998), pp. 275-284
Drugs affecting serotonin neurons (1990)

Advances in serotonin pharmacology, the development of drugs that intervene at specific sites to modify serotonergic function, have accompanied advances in the understanding of physiologic roles of serotonin present in neurons and elsewhere and of serotonin receptors that are widely distributed in brain and many peripheral tissues. The pharmacologic advances have sometimes been stimulated by developments in serotonin physiology, such as the recognition of multiple serotonin receptor subtypes, and in other cases have been a major factor in providing new insights into physiologic roles of serotonin. Drugs that modify serotonin function have a variety of therapeutic applications currently and many more potential therapeutic uses to be explored in the future. Having drugs that act with high specificity or selectivity on particular enzymes in serotonin biosynthesis, on particular serotonin receptors, or at other sites such as uptake carriers for serotonin not only offers the hope of improved clinical therapy in diseases caused by abnormal serotonergic function or in which alteration of serotonergic function can alleviate symptoms, but also provides valuable pharmacologic tools for learning more about serotonin physiology and probing the functional status of serotonergic systems. The next few years promise to yield important new serotonergic drugs.
Structure of Petroleum Asphaltene and Its Significance (1974)

Abstract The accumulated experimental results over the last five decades in the field of high molecular-weight fractions of petroleum has helped us to build a working model for the average structure of resins, asphaltenes, and other bitumens. The complex nature of the average structure requires analysis in terms of both a micro-structure (fine) and a macro-structure (bulk). The former, which is obtained from chemical methods, can be defined by a number of structural parameters such as aromaticity, substitution extent, etc.; the latter, obtained by physical approaches, deals with dissociation-association, charge-transfer, excitation, defect centers, etc. This macro-molecular model of multipolymer nature is consistent with models of geochemically related substances. Applications based on the structural information derived from heavy ends not only include prediction of physical properties and chemical reactions, but also include improvement of existing technology. In the geochemical domain it is anticipated that there will be better methods for prospecting and production. Better insight can be directed toward refining and product evaluation. Existing asphalt coating and paving technology can be put on a more sound scientific basis. Better source identification and flocculation techniques can be developed for environmental protection against oil spillage.
Microfluidic Gas‐Flow Imaging Utilizing Parahydrogen‐Induced Polarization and Remote‐Detection NMR (2010)

Sensitivity enhancement of several orders of magnitude provided by combining parahydrogen-induced polarization (PHIP) and remote-detection (RD) NMR techniques enables gas-flow visualization in microfluidic devices (see scheme). A 7700-fold reduction in the imaging time compared to the current state-of-the-art is achieved, and it can also be used to significantly improve the spatial resolution in such experiments.
Xyloglucan for the treatment of acute diarrhea: results of a randomized, controlled, open-label, parallel group, multicentre, national clinical trial (2015)

EudraCT number 2014-001814-24 (date: 2014-04-28) ISRCTN number: 90311828.
Co-deposition of conducting polymers in a room temperature ionic liquid (2009)

This work focuses on the co-deposition of two different conducting polymers in a room temperature ionic liquid. The combination of poly(pyrrole) (PPy) and poly(3,4-ethylenedioxythiophene) (PEDOT) is investigated in 1-butyl-methylpyrrolidinium bis(trifluoromethanesulfonyl)imide (C4mpyr TFSI). In the past, the deposition of the homopolymers from ionic liquids has proven difficult with the resultant layers exhibiting poor kinetics of both the charge and discharge reactions. Combining the two polymers as one layer, using a mixed monomer solution in an ionic liquid as the deposition media, creates a superior polymer layer. Desirable properties of the poly(pyrrole) are high specific capacitance and good mechanical properties while the desirable properties of the poly(thiophene) derivative are high electrical conductivity, good mechanical properties and high porosity. Characterisation of the co-deposited polymer layers is carried out using cyclic voltammetry, capacitance measurements, electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM) imaging. The co-deposited film is found to exhibit an improved morphology and higher ionic transport, while maintaining a similar specific capacitance to the homo-polymer PPy.
Polyphase filterbanks for symbol timing synchronization in sampled data receivers (2003)

Symbol timing synchronization is an important component in a receiver designed to recover data from a digitally modulated waveform. Current trends favor sampled data architectures to perform the synchronization, matched filtering, and detection required to recover the data. Symbol timing synchronizers in a sampled data receiver differ from their continuous-time counterparts: the functionality in a sampled data receiver is an adaptive interpolator as opposed to a sample and hold. This paper describes the use of a polyphase filter bank for symbol timing synchronizers in sampled data receivers. Using this approach, interpolation and matched filtering are rolled into a single operation that requires less resources than separate filters for matched filtering and interpolation. Interpolations are realized by filter bank index selection. Since the filter bank index plays the role of the fractional interpolation interval, the same loop control techniques used in other sampled data synchronizers can be used. Maximum likelihood timing synchronization techniques as well as "early-late gate" techniques can be incorporated into the polyphase filter bank in a natural way.