gebhart/patrepeval huggingface dataset:
Reactivity of Aluminum Nitride Powder in Dilute Inorganic Acids (2000)

The reactivity of AlN powder in diluted inorganic acids was studied by measuring the pH and temperature during its hydrolysis. At very low starting pH (pH ∼1) no reaction was observed, regardless of the acid used. In contrast, in a less acidic environment, i.e., at higher pH values (pH ∼3), the reaction was fast enough to reveal the influence of different acids on the hydrolysis reaction. Monoprotonic acids which are completely dissociated (HCl, HF, HNO 3 ), and form water‐soluble salts with aluminum, did not influence the hydrolysis reactions. In the presence of incompletely dissociated diprotonic H 2 SO 4 and H 2 CO 3 acids which form water‐soluble salts with aluminum, the reaction was hindered but not prevented. In the presence of phosphoric acid the hydrolysis was prevented at room temperature, presumably because of the formation of insoluble phosphates on the powder surface. At elevated temperatures their solubility was substantial, and the reactivity of AlN powder in a diluted hot phosphoric acid was reestablished. In the presence of silicic acid the reaction was suppressed at both room and elevated temperatures, which was also ascribed to the formation of insoluble silicates. The adsorption of silicate anions onto the powder surface was confirmed by chemical analysis and zeta potential measurement. Using DRIFT measurements, however, the presence of Si–O bonds on the powder could not be unambiguously confirmed, since the characteristic wavelengths for these bonds are in the region of very strong Al–N stretching frequencies.
Investigations with the Specific μ-Opiate Receptor Agonist Fentanyl in Depressive Patients: Growth Hormone, Prolactin, Cortisol, Noradrenaline and Euphoric Responses (1989)

15 depressive patients and 15 controls, 9 of them age- and sex-matched, were administered 0.2 mg/70 kg i.v. fentanyl, a specific and highly potent mu-opiate receptor agonist. Growth hormone response was significantly reduced in depressive patients in comparison to controls, whereas prolactin response did not significantly differ between the two groups. Cortisol plasma concentration increased in depressive patients and decreased in controls. The difference between the groups failed to reach statistical significance. Only in patients, but not in controls, fentanyl led to a significant increase in plasma noradrenaline. In contrast, a significant increase in the visual analogue scale for the evaluation of psychotropic drug effects was found only in controls after fentanyl administration. From these preliminary results in connection with other studies we conclude a possible involvement of a disturbed opioid system at least in a subgroup of depressive patients.
gSLIC: a real-time implementation of SLIC superpixel segmentation (2011)

We introduce a parallel implementation of the Simple Linear Iterative Clustering (SLIC) superpixel segmentation. Our implementation uses GPU and the NVIDIA CUDA framework. Using a single graphic card, our implementation achieves speedups of 10x∼20x from the sequential implementation. This allow us to use the superpixel segmentation method in real-time performance. Our implementation is compatible with the standard sequential implementation. Finally, the software is now online and is open source.
Clinical implications of the novel cytokine IL-38 expressed in lung adenocarcinoma: Possible association with PD-L1 expression (2017)

Interleukin (IL)-38, a novel member of the IL-1 cytokine family, is homologous to IL-1 receptor antagonist (IL-1Ra) and IL-36Ra, and has been reported to act as an antagonist. IL-38 expression is found in tonsil, placenta, and spleen, and recent studies suggest an association between IL-38 and autoimmune diseases. However, whether IL-38 plays a role in carcinogenesis or cancer growth is unclear. In the present study, we identified increases in IL-38 expression by immunohistochemistry in multiple types of cancer cells. In the examination of 417 surgically resected primary lung adenocarcinomas, Fisher's exact tests showed significant associations between high IL-38 expression and high tumor grades, an advanced T status, advanced N status, advanced stage, and the presence of pleural and vessel invasions. Survival analyses by the Kaplan-Meier method showed that patients with high expression of IL-38 had significantly shorter disease-free survival and shorter overall survival after surgery than patients with low expression of IL-38 (log-rank test: P = 0.0021 and P = 0.0035, respectively). Moreover, programmed cell death-ligand 1 (PD-L1)-positive cases showed higher expression of IL-38 than PD-L1-negative cases (Wilcoxon rank-sum test: P < 0.0001). In conclusion, IL-38 was expressed in tumor cells of various cancers, and IL-38 expression was associated with poor survival of lung adenocarcinoma patients. IL-38 may affect host immunity or the tumor microenvironment, and contribute to the progression of lung adenocarcinoma.
Gene marking and gene therapy directed at primary hematopoietic cells (1996)

The past year has been a very active one in the field of gene transfer to hematopoietic targets, specifically stem cells and T cells. A number of clinical trials were published that both demonstrated progress as well as identified problems that investigators will face in trying to make the technology therapeutically applicable. Important laboratory and animal experiments focused on predictive models for human stem cell behavior, methods for culturing and expanding primitive cells ex vivo, immune responses against transgenes, in vitro and in vivo selection of transduced cells, and alternatives to standard retroviral vectors.
Determination and Validation of Off-Target Activities of Anti-CD44 Variant 6 Antibodies Using Protein Biochips and Tissue Microarrays (2008)

We describe a novel procedure for determination and validation of off-target activities of anti-cluster designation antigen identity 44 (CD44) variant 6 recombinant antibodies by combining two complementary technology platforms; namely UNIchip AV-400, containing a printed serial dilution of CD44 variant 6 and approximately 400 different human proteins, and TISSOMICS, enabling human tissue microarray analysis in high-throughput mode. We have analyzed the performance of two human monoclonal recombinant antibodies directed against CD44 variant 6 protein, BMS 116 and BMS 125, in a blinded study. The antibodies exhibit a clear differentiation with regard to their binding profiles in the two systems. BMS 116 shows a low degree of specificity in the normal human Food and Drug Administration (FDA) tissue panel, which was confirmed by binding to more than 206 proteins on the protein biochip. In contrast, BMS 125 gives a highly selective membranous staining on selected human epithelial tissue components with no off-target activities observed on the protein biochip. Additionally, antibody BMS 125 shows a higher sensitivity to its antigen CD44 variant 6 than antibody BMS 116 as determined by the protein biochip.
Broad-Band Multilayer Film for Fabry-Perot Interferometers* (1956)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Philip W. Baumeister and John M. Stone, "Broad-Band Multilayer Film for Fabry-Perot Interferometers*," J. Opt. Soc. Am. 46, 228-229 (1956) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Rapid Automated Induction Lamination (RAIL) for High-Volume Production of Carbon/Thermoplastic Laminates (2001)

An innovative Rapid Automated Induction Lamination (RAIL) process has been developed that can fabricate fully consolidated 8-ply AS4/polyetherimide (PEI) laminates in high volumes. The process relies on induction-based rapid volumetric heating for multilayer consolidation at very rapid rates (less than 30-s cycle times), while maintaining high quality (< 1% voids). Pull translation of mechanical properties has been achieved in comparison to baseline processes, such as autoclave and vacuum debulk with an order of magnitude increase in throughput. The RAIL process has the potential to be integrated with thermoforming for high-volume production of net-shape carbon/thermoplastic parts.
Engineering of the interactions of volatile organic compounds with MoS<sub>2</sub> (2017)

We investigate the interactions between volatile organic compounds (VOCs, including ethanol, acetone and propanal) and pristine, defective and transition metal-functionalized MoS<sub>2</sub>using the first-principles method.
Angular measurements of light scattered by turbid chiral media using linear Stokes polarimeter (2006)

The effects of turbid chiral media on light polarization are studied in different directions around the scattering samples using a refined linear Stokes polarimeter, which simplifies the signal analysis, and allows for the detailed investigations of scattered light. Because no moving parts are involved in a measurement at a specific detection direction, the determination accuracy of polarization states is increased. The results show that light depolarization increases with both turbidity and detection angle for low and moderately turbid samples; however, the angular dependence decreases with increasing turbidity. When the turbidity is increased to approximately 100 cm(-1), the depolarization becomes higher in the forward than in the backward direction. Polarization sensitive Monte Carlo simulations are used to verify some experimental observations. The results also demonstrate that surviving linear polarization fraction and overall intensity are more sensitive to the increase of glucose concentration in backward than in the forward direction in highly turbid media, indicating that backward geometry may be preferable for potential glucose detection in a biomedical context. Comparison measurements with optically inactive glycerol suggest that the refractive index matching effect, and not the chiral nature of the solute, dominates the observed optical rotation engendered by glucose in highly turbid media.
CT dose reduction using dynamic collimation (2011)

The purpose of this work is to define and calculate the motion requirements of dynamic collimators that can significantly reduce dose in CT scans. Both axial and transverse collimators are modeled and compared in terms of their velocity requirements. Today, helical scans already use the axial collimator. A separate transverse dynamic collimator is proposed that would be used for both helical and axial scans. The leaves of both the helical and transverse collimators move such that only those x-rays that intersect a predefined VOI are exposed to the patient. To assess the motion control requirements for the transverse collimator, the velocity of each leaf is determined for a circular region of interest (ROI) at a given distance from scan center. These velocity profiles are then compared to those of a helical collimator for a typical helical scan with an 8 cm detector and .3 second rotation time. The maximum velocity incurred by the helical collimator for a scan with a pitch factor of 1.4 is about 23 cm/sec. For a 12 cm cardiac scan located 18 cm from scan center, the maximum velocity of a transverse collimator positioned 27 cm from the source is 198 cm/sec. Three options (or combination thereof) to address the higher velocities are: 1) Position the patient such that the VOI is closer to scan center 2) Move the dynamic transverse collimator closer to the source 3) Upgrade the collimator motor controller.
Electro‐deposition tangsten coating on low activation steel substrates from Na <sub>2</sub> WO <sub>4</sub> ‐ZnO‐WO <sub>3</sub> melt salt (2012)

Abstract Tungsten coating is considered as a promising alternative material for plasma facing materials (PFC) in future fusion devices. The electro‐deposition of tungsten in Na 2 WO 4 ‐ZnO‐WO 3 melt at 1173 K on low activation steel substrates was studied in this work. Adherent and smooth tungsten films were deposited under various pulsed current conditions. The crystal structure and microstructure of tungsten deposits were characterized by XRD, SEM and EDX techniques. The results show that pulsed current density and duty cycle have a significant influence on tungsten nucleation and electro‐crystallization phenomena. Uniform and smooth tungsten coating with high purity and high adherence is obtained on low active steel substrates as cathodic current density ranges from 35 to 25 mA·cm −2 .
Magnetic Contact Duplication Using Lithographically Patterned Master Medium. (2001)

A magnetic contact duplication technique using a lithographically patterned master medium was investigated in order to write a servo signal on hard disks and floppy disks at high speed and low cost. In this technique, the coercivity of the master medium is low, and a dc magnetic field is applied to a slave medium in contact with the master medium. Experimental and computer simulation results show that the degree of magnetic duplication becomes better and then saturates as the magnetic layer thickness of the master becomes thicker. Magnetic duplication performance improves with the increase of Ms of the master.
The Effect of Heat and Stretching on the Range of Hip Motion (1984)

Flexion, abduction, and external rotation of the hip joint were recorded in 30 volunteers randomized into three groups of 10. The measurements were taken before, immediately after, and 30 minutes after treatment of heat, stretching and a combination of heat plus stretching. Heat only did not improve the range of motion of the hip joint. Stretching increased flexion and external rotation, and heat plus stretching in combination gave the greatest increase in flexion motion, and also significantly increased abduction. External rotation after stretching treatment, and flexion and abduction after heat plus stretching treatment were still significantly increased after 30 minutes.J Orthop Sports Phys Ther 1984;6(2):110-115.
Hybrid Auto-Scaling for an Asynchronous Computationally Intensive Application (2020)

Cloud computing has developed rapidly in recent years. It enables users to access computing resources on an on-demand basis, acquiring resources when an application requires them and releasing them when they are no longer needed. This characteristic of cloud computing or elasticity as it is often referred to raises an interesting question of how to manage these resources efficiently, as there is a tradeoff between minimizing resource cost and meeting the Quality of Service (QoS) requirements. The choice of an auto-scaler can significantly affect both resource consumption and QoS in cloud applications. Container orchestration systems such as Kubernetes rely on static thresholds and low-level infrastructure metrics such as CPU and memory to scale cloud applications and foresee workloads that arise at runtime. This research presents a hybrid auto-scaling method using both reactive and proactive metrics for an asynchronous computationally intensive application used in a publish-subscribe pattern. The new hybrid method is compared to Kubernetes Horizontal Pod AutoScaler (HPA), both with synthetic and real-world workloads. Based on the experimental results, both methods are compared in regard to resource consumption and QoS. For the synthetic workloads, it used, on average, 39.44% fewer pods than HPA, and 52,97% increased CPU utilization, while providing a similar and often more reliable QoS than HPA. For the real-world workload, the method presented in this thesis used, on average, 47.26% fewer pods than HPA. Furthermore, it had a 73.78% increased CPU utilization, while averaging a significantly smaller queue and less latency compared to HPA.
ManiGAN: Text-Guided Image Manipulation (2020)

The goal of our paper is to semantically edit parts of an image matching a given text that describes desired attributes (e.g., texture, colour, and background), while preserving other contents that are irrelevant to the text. To achieve this, we propose a novel generative adversarial network (ManiGAN), which contains two key components: text-image affine combination module (ACM) and detail correction module (DCM). The ACM selects image regions relevant to the given text and then correlates the regions with corresponding semantic words for effective manipulation. Meanwhile, it encodes original image features to help reconstruct text-irrelevant contents. The DCM rectifies mismatched attributes and completes missing contents of the synthetic image. Finally, we suggest a new metric for evaluating image manipulation results, in terms of both the generation of new attributes and the reconstruction of text-irrelevant contents. Extensive experiments on the CUB and COCO datasets demonstrate the superior performance of the proposed method.
Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis (2008)

To describe signal and contrast properties of an isotropic, single-slab 3D dataset [double inversion-recovery (DIR), fluid-attenuated inversion recovery (FLAIR), T2, and T1-weighted magnetization prepared rapid acquisition gradient-echo (MPRAGE)] and to evaluate its performance in detecting multiple sclerosis (MS) brain lesions compared to 2D T2-weighted spin-echo (T2SE). All single-slab 3D sequences and 2D-T2SE were acquired in 16 MS patients and 9 age-matched healthy controls. Lesions were scored independently by two raters and characterized anatomically. Two-tailed Bonferroni-corrected Student's t-tests were used to detect differences in lesion detection between the various sequences per anatomical area after log-transformation. In general, signal and contrast properties of the 3D sequences enabled improved detection of MS brain lesions compared to 2D-T2SE. Specifically, 3D-DIR showed the highest detection of intracortical and mixed WM-GM lesions, whereas 3D-FLAIR showed the highest total number of WM lesions. Both 3D-DIR and 3D-FLAIR showed the highest number of infratentorial lesions. 3D-T2 and 3D-MPRAGE did not improve lesion detection compared to 2D-T2SE. Multi-contrast, isotropic, single-slab 3D MRI allowed an improved detection of both GM and WM lesions compared to 2D-T2SE. A selection of single-slab 3D contrasts, for example, 3D-FLAIR and 3D-DIR, could replace 2D sequences in the radiological practice.
Spread-spectrum UHF encrypted-command patient link (2003)

A wide-bandwidth frequency-hopped spread-spectrum UHF radio biomedical interface is discussed. The interface allows two-way patient voice link, input/output patient physiologic links, and a physician/paramedic two-way voice command link. A simple UHF transceiver is worn by the patient. The signals are received by a fixed transceiver interfaced to an appropriate monitoring function.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The importance of propargylamine moiety in the anti‐ Parkinson drug rasagiline and its derivatives for MAPK‐ dependent amyloid precursor protein processing (2003)

Rasagiline [N-propargyl-(1R)-aminoindan] a highly potent selective irreversible monoamine oxidase (MAO)-B inhibitor exerts neuroprotective and antiapoptotic effects against a variety of insults in cell cultures and in vivo and has finished its phase III clinical trials for Parkinson's disease. In the present study, we show that rasagiline (1 and 10 microM) significantly protected rat PC12 cells against beta-amyloid (Abeta1-42) toxicity. In addition, rasagiline significantly increased (approximately threefold) the secretion of the nonamyloidogenic soluble form of the amyloid precursor protein (sAPPalpha) from SH-SY5Y neuroblastoma and PC12 cells. The increase of sAPPalpha was dose-dependent and was blocked by the hydroxamic acid-based metalloprotease inhibitor Ro31-9790 (100 microM), suggesting that the effect is mediated via alpha-secretase activity. Rasagiline-induced sAPPalpha release was significantly reduced by the inhibitors of protein kinase C (PKC), GF109203X, and ERK mitogen-activated protein kinase (MAPK) PD98059. Moreover, rasagiline dose dependently (0.1-10 microM) increased the phosphorylation of p44 and p42 MAPK, which was abolished by PD98059 (30 microM) and GF109203X (2.5 microM). By comparing the actions of rasagiline with those of its S-isomer TVP1022, which is not an MAO inhibitor, we have been able to demonstrate that MAO-B inhibition is not a prerequisite for either sAPPalpha-induced release or ERK phosphorylation. In addition, structure-activity relationship among rasagiline-related compounds suggests the crucial role of the propargyl moiety in these molecules, because propargylamine itself significantly induced the secretion of sAPPalpha and increased MAPK phosphorylation with similar potency to that of rasagiline and its derivatives.
Pilot plant production of glucose with glucoamylase immobilized to porous silica (1976)

Glucoamylase was immobilized to porous silica and its kinetics and stability were observed with acid- and alpha-amylase-hydrolyzed dextrin as feed. The enzyme was found to be extremely stable in both laboratory and pilot plant operations. When the feed had been previously only lightly hydrolyzed, pore diffusion limitation caused appreciable decreases in glucose production rate. The severity of starch hydrolysis to dextrin markedly affected ultimate glucose yields. The diffusional gradients present in the carrier pores caused the immobilized enzyme to yield lower glucose concentrations than the free enzyme at similar feed conditions.
Involvement of Streptococcal Mitogenic Exotoxin Z in Streptococcal Toxic Shock Syndrome (2005)

We report a nonfatal case of streptococcal toxic shock syndrome (STSS) caused by a Streptococcus pyogenes emm118 strain encoding a novel variant of streptococcal mitogenic exotoxin Z (SMEZ-34). This variant was responsible for the major mitogenic activity in the cell culture supernatant. Patient sera showed seroconversion toward SMEZ, implying a role for this toxin in STSS.