gebhart/patrepeval huggingface dataset:
Using Genetic Approaches To Delineate the Pathway of Contact-Dependent Growth Inhibition (2014)

The study of the phenomenon of contact-dependent growth inhibition (CDI) began with the observation that in mixed cultures of Escherichia coli, an E. coli strain from the intestine of a rat designated EC93 inhibited the growth of differentially marked (antibiotic resistances) K-12 bacteria in the same culture. The authors say that they are not aware of the function(s) of contact-dependent growth inhibition (CDI) systems in the many different bacterial genera containing CDI homologues at the time of the writing this chapter, although progress in this area is being made. The chapter is an account of the genetic approaches the authors have used to explore CDI, including some anomalies and stumbling blocks that may be of interest to the reader. To identify the cellular factors that play roles in CDI, the authors took a series of genetic approaches. Initially, a transposon EZ-Tn5<KAN-2> library was constructed in E. coli EPI100 ( Epicentre) target cells. To identify the cellular factors that play roles in CDI, the authors took a series of genetic approaches. They observed a number of mucoid colonies in selection scheme described from which acrB insertions conferring CDI resistance were identified, as well as a similar mutant selection using chemical mutagenesis. To study the mechanism of contact-dependent growth inhibition, the authors developed a CDI autoinhibition system in which growth inhibition is regulated by controlling expression of the cdil immunity gene. The necessity of an energy source for growth recovery raised the question of what role metabolism plays in CDI.
Automatic recognition of spike and wave bursts. (1985)

This paper reviews previous methods and describes a new method for the detection of spike and wave bursts in a single EEG channel. The complete detector is readily implemented in a 16-bit microprocessor. The burst detection relies on the detection of both spikes and waves and also imposes a requirement on the repetition rate of the slow waves. The system agreement with electroencephalographers was over 90% for spike and wave bursts longer than 3 sec in duration, with a false detection rate of one error in 5.8 h for bursts of the same length. The system also computes the mean value and variance of the amplitude and duration of the spikes and slow waves as well as the period of the spike and wave complexes. The EEGs of 6 patients suffering from petit mal epilepsy were analyzed. The variance of the amplitude measures was found to be much greater than that of the period measurements. For all patients the repetition period of the waves decreased for longer bursts, as did the variability of the repetition period. The difficult problem of false detections due to artifacts is discussed in detail.
Effect of particle size distribution upon specific surface area and ultrasonic velocity in sintered ceramic powders (1998)

The changes in ultrasonic sound wave velocity and specific surface area which occur as a result of sintering have been correlated for several zinc oxide and alumina powder systems. Particle size distribution is shown to have a significant effect upon the nature of this correlation. Powders with narrow particle size distributions exhibit a nearly linear relationship between the surface area reduction and the longitudinal wave velocity over much of the initial and intermediate stages of sintering. In contrast, powders with broad particle size distributions exhibit a significant reduction in the specific surface area, with little increase in the ultrasonic velocity, during the early stages of sintering. This behavior is attributed to the differences in the thermodynamic driving forces for sintering of the different sized particles. These data also indicate that in powder compacts containing broad particle size distributions, the apparent elastic moduli, as manifested in the ultrasonic velocity, are dominated by the larger particles. The present work contributes to the understanding of the dynamic behavior of sintering powder compacts in terms of the ultrasonic velocity, which may be determined non-intrusively during processing. This understanding may facilitate the use of ultrasonic techniques for real-time monitoring and controlling of the sintering process in ceramic power compacts.
AlGaN/GaN-heterojunction FET with inverted 2DEG Channel (2003)

Novel heterojunction AlGaN/GaN-FET with inverted device channel is investigated.FET-heterostructures were grown by MBE on sapphire substrates. Devices were fabricated with 0,25 µ T-shaped gates,using electron beam lithography.Electron density profile under the device gate has demonstrated localization of electrons in very narrow nm-region (<10nm)at the bottom GaN/AlGaN – interface,giving direct evidence of HEMT-nature of our FET ’s.I - V-characteristics of HEMT ’s demonstrated high value of drain current Id max >1A/mm,and good extrinsic transconductance gm ext ≅140mS/mm.DC - specific output power of HEMT was 2,0W/mm.Extrinsic cut off frequency f τ ext of HEMT,determined from transconductance gm and gate-source capacitance Cgs, was 20GHz.Its intrinsic value,f τ ext ,was found to be as high as 36GHz.
Defects in ryanodine receptor calcium release in skeletal muscle from postmyocardial infarcted rats (2003)

Defective calcium (Ca2+) signaling and impaired contractile function have been observed in skeletal muscle secondary to impaired myocardial function. However, the molecular basis for these muscle defects have not been identified. In this study, we evaluated the alterations of the ryanodine-sensitive Ca2+ release channels (RyR1) by analyzing global and local Ca2+ signaling in a rat postmyocardial infarction (PMI) model of myocardial overload. Ca2+ transients, measured with multiphoton imaging in individual fibers within a whole extensor digitorum longus (EDL) muscle, exhibited significantly reduced amplitude and a prolonged time course in PMI. Spatio-temporal properties of spontaneous Ca2+ sparks in fibers isolated from PMI EDL muscles were also significantly altered. In addition, RyR1 from PMI skeletal muscles were PKA-hyperphosphorylated and depleted of the FK506 binding protein (FKBP12). These data show that PMI skeletal muscles exhibit altered local Ca2+ signaling, associated with hyperphosphorylation of RyR1. The observed changes in Ca2+ signaling may contribute to defective excitation-contraction coupling in muscle that can contribute to the reduced exercise capacity in PMI, out of proportion to the degree of cardiac dysfunction.
Visualizing the Behavior of an Elastic, Energy-Efficient Database Cluster. (2015)

Energy efficiency in databases is an emerging topic. Our research prototype WattDB dynamically adjusts the number of active servers in a cluster to the current workload to achieve energy proportionality. In this demo, we give insights in the partitioning process and WattDB’s reaction to workload changes by live-presenting a monitoring GUI. The whole process and the resulting configuration are visualized to give immediate feedback, how the cluster would react.
CORRECTION (1942)

I AM indebted to Eugene S. McCartney for calling attention to an error in my article on "The use of generic names as common nouns," SCIENCE, Vol. 96, p. 252. "Pelomyxa carolinensis," line 13, should be omitted, for "carolinensis" is not a noun in the genitive case, but an adjective in the nominative case.
THE REACTION OF SULFUR DICHLORIDE WITH <i>cis</i>,<i>cis</i>-1,5-CYCLOOCTADIENE (1966)

Transannular additions of sulfur dichloride to various cyclic and bicyclic di- and poly-olefins have been disclosed recently. Our observations on the reaction product from cis,cis-cyclooctadiene are reported inasmuch as they supplement the previous findings.
Women, Conservatism, and Social Welfare (1982)

The timing of this special issue is particularly fortunate, coming as it does during a period of reassessment and retrenchment in the women's movement. The attacks of the New Right, the defeat of the Equal Rights Amendment, and the growing maturity and sophistication of the women's movement, have spurred an intense reexamination and reanalysis of basic tenets and strategies. The articles in this special issue, although broadly diverse, reflect this effort to come to a deeper analysis of women's oppression and of effective ways to overcome it.
Ionic polymerization of diphenylvinylphosphine oxide (1963)

Abstract Grignard reagents, organolithium compounds, sodium naphthalene and aluminum alkyl—metal halide catalysts were examined as initiators for the polymerization of diphenylvinylphosphine oxide. The most effective catalysts studied were Grignard reagents and sodium naphthalene. With Grignard catalysis, polymers of molecular weight up to ∼10,000 were produced although the yield, molecular weight, and crystallinity of the products were influenced by the organic and halide components of the catalyst and by the reaction solvent. Copolymerization studies indicated that the anionic reactivity of diphenylvinylphosphine oxide is between those of styrene and methyl methacrylate. For Grignard catalysis an anionic‐type polymerization mechanism is proposed which requires the formation of polymer—organomagnesium halide adducts in the transition state.
Pre- and post-exposure prophylaxis of experimental Burkholderia pseudomallei infection with doxycycline, amoxicillin/clavulanic acid and co-trimoxazole (2008)

Co-trimoxazole appears to be an effective oral antibiotic both as pre- and post-exposure prophylaxis to B. pseudomallei. Data derived from this study have important implications on the management of laboratory accidents or following an intentional release of B. pseudomallei, a potential bioterrorism agent.
The bowed string and the player (1973)

Relations between bowing parameters, i.e., force applied, bow position, and velocity, are derived in terms of load impedance presented by bridge to string, characteristic impedance, and frictional coefficients. The range between least applied force needed to couple bow to load during sticking and maximum permitting uncoupling following sticking provides the generous tolerance, variable but typically in the ratio of 1 to 10, that makes the bowed string so flexible in performance. Domains of string behavior recognized by players are related graphically to bowing parameters. An electromagnetic method for observing particle velocity in the string reveals small but significant ripples caused by forces at the bow that the idealized explanation ignores. In one very flexible string, force exerted on the bridge varied approximately inversely with frequency out to the 15th harmonic, whereas for a string equivalent to a gut G for violin force became zero near the 7th. Elastic effects are considered, and it is suggested that in strings, either solid or wound, inharmonicity of 0.1 cent per square of mode number will not perceptibly degrade bowed-string performance.
Uranyl mediated photofootprinting reveals strong<i>E.coli</i>RNA polymerase-DNA backbone contacts in the +10 region of the<i>Deo</i>P1 promoter open complex (1989)

Employing a newly developed uranyl photofootprinting technique (Nielsen et al. (1988) FEBS Lett. 235, 122), we have analyzed the structure of the E. coli RNA polymerase deoP1 promoter open complex. The results show strong polymerase DNA backbone contacts in the -40, -10, and most notably in the +10 region. These results suggest that unwinding of the -12 to +3 region of the promoter in the open complex is mediated through polymerase DNA backbone contacts on both sides of this region. The pattern of bases that are hyperreactive towards KMnO4 or uranyl within the -12 to +3 region furthermore argues against a model in which this region is simply unwound and/or single stranded. The results indicate specific protein contacts and/or a fixed DNA conformation within the -12 to +3 region.
A Comparison of the Hydrodesulfurization and Hydrodenitrogenation Activities of Monolith Alumina Impregnated with Cobalt and Molybdenum and a Commercial Catalyst (1981)

The hydrodesulfurization (HDS) and hydrodenitrogenation (HDN) activities of two Co-Mo-alumina catalysts were tested on two coal derived liquids using a trickle bed reactor system. The two liquids used were; Synthoil liquid (high-boiling stock) and Raw Anthracene Oil (low-boiling stock). One of the two catalysts was prepared in the laboratory at Oklahoma State University by impregnating Co and Mo on the Monolith alumina supports received from the Corning Glass Company. The other catalyst used was Nalcomo 474 (a commercial preparation) received from Nalco Chemical Company (now Katalco). The results of this study indicated that at the reactor operating conditions of 371 C and 1500 psig, the observed HDS activity based on unit surface area was higher for the Monolith catalyst as compared to the Nalcomo 474 catalyst when processing the heavier feedstock, Synthoil liquid. But HDS activity was about the same when processing the lighter feedstock, Raw Anthracene Oil. Since the average pore radius and the intraparticle diffusion length of the Monolith catalyst were 80°A and 0.114 mm versus 33°A and 1 mm of the Nalcomo 474 catalyst, the intraparticle diffusion was considered to be responsible for the lower observed activity of the Nalcomo 474 catalyst on the heavier feedstock. From the observed rates of reaction, the effectiveness factors for the Monolith and Nalcomo 474 catalysts were found to be 0.94 and 0.216 respectively for the HDS of Synthoil.
Conflict negotiation among personal calendar agents (2006)

We will demonstrate distributed conflict resolution in the context of personalized meeting scheduling. The demonstration will show how distributed constraint optimization can be used to facilitate interaction between cognitive agents and their users. The system is part of the CALO personal cognitive assistant that will also be explored during the demonstration.
Dental Hardware Complicating Diagnosis in Refractory Gelastic Epilepsy Secondary to Hypothalamic Hamartoma (2010)

Hypothalamic hamartomas (HH) are developmental malformations of the hypothalamus associated with a potentially treatable epileptic encephalopathy, characterized by early onset gelastic seizures, the later development of multiple seizure types and progressive cognitive and behavioral decline. Surgical treatment of HH can lead to seizure control and improvement in the cognitive-behavioral syndrome. Video-EEG telemetry (VET) is often necessary to characterize the semiology of the seizures, but there are no specific interictal or ictal EEG pattems that will confirm the diagnosis. Magnetic resonance imaging (MRI) can identify HH and define their anatomy, but the imaging findings may be subtle and susceptible to artifactual contamination. We present a patient with intractable gelastic epilepsy in whom the diagnosis of HH was initially missed due to failure to recognize the clinical syndrome and contamination of the MRI images with dental hardware artifact. VET confirmed the clinical diagnosis and the HH was identified on MRI after the dental hardware was removed. VET should be performed to confirm seizure semiology in patients with suspected gelastic epilepsy. Establishing this diagnosis can subsequently direct the appropriate neuroradiological evaluation for HH and surgical treatment of these lesions.
Ionizing Radiation Triggers Chromatin-bound kin17 Complex Formation in Human Cells (2002)

The human DNA-binding (HSA)kin17 protein cross-reacts with antibodies raised against the stress-activated Escherichia coli RecA protein. We show here that (HSA)kin17 protein is directly associated with chromosomal DNA as judged by cross-linking experiments on living cells. We detected increased amounts of DNA-bound (HSA)kin17 protein 24 h after gamma irradiation, with 2.6-fold more (HSA)kin17 molecules after 6 Gy of irradiation (46,000-117,000 molecules). At this time we observed that highly proliferating RKO cells displayed the concentration and co-localization of (HSA)kin17 and replication protein A in nucleoplasmic foci. Our results suggest that 24 h post-irradiation (HSA)kin17 protein may localize at the sites of unrepaired DNA damages. RKO clones expressing an (HSA)KIN17 antisense transcript (RASK.5 and RASK.13 cells) revealed that reduced (HSA)kin17 protein levels are correlated with a decrease in clonogenic cell growth and cell proliferation, as well as an accumulation of cells in early and mid-S phase. Taken together our observations support the idea that (HSA)kin17 protein is a DNA maintenance protein involved in the cellular response to the presence of DNA damage and suggest that it helps to overcome the perturbation of DNA replication produced by unrepaired lesions.
Rational Development of Ternary Alloy Electrocatalysts (2012)

Improving the efficiency of electrocatalytic reduction of oxygen represents one of the main challenges for the development of renewable energy technologies. Here, we report the systematic evaluation of Pt-ternary alloys (Pt3(MN)1 with M, N = Fe, Co, or Ni) as electrocatalysts for the oxygen reduction reaction (ORR). We first studied the ternary systems on extended surfaces of polycrystalline thin films to establish the trend of electrocatalytic activities and then applied this knowledge to synthesize ternary alloy nanocatalysts by a solvothermal approach. This study demonstrates that the ternary alloy catalysts can be compelling systems for further advancement of ORR electrocatalysis, reaching higher catalytic activities than bimetallic Pt alloys and improvement factors of up to 4 versus monometallic Pt.
The Transcriptional Repressor K-RBP Modulates RTA-Mediated Transactivation and Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus (2007)

The replication and transcription activator (RTA) protein of Kaposi's sarcoma (KS)-associated herpesvirus (KSHV)/human herpesvirus 8 functions as the key regulator to induce KSHV lytic replication from latency through activation of the lytic cascade of KSHV. Elucidation of the host factors involved in RTA-mediated transcriptional activation is pivotal for understanding the transition between viral latency and lytic replication. KSHV-RTA binding protein (K-RBP) was previously isolated as a cellular RTA binding protein of unknown function. Sequence analysis showed that K-RBP contains a Kruppel-associated box (KRAB) at the N terminus and 12 adjacent zinc finger motifs. In similarity to other KRAB-containing zinc finger proteins, K-RBP is a transcriptional repressor. Mutational analysis revealed that the KRAB domain is responsible for the transcriptional suppression activity of this protein and that the repression is histone deacetylase independent. K-RBP was found to repress RTA-mediated transactivation and interact with TIF1beta (transcription intermediary factor 1beta), a common corepressor of KRAB-containing protein, to synergize with K-RBP in repression. Overexpression and knockdown experiment results suggest that K-RBP is a suppressor of RTA-mediated KSHV reactivation. Our findings suggest that the KRAB-containing zinc finger protein K-RBP can suppress RTA-mediated transactivation and KSHV lytic replication and that KSHV utilizes this protein as a regulator to maintain a balance between latency and lytic replication.
Structure‐Activity Relationships for Some Diamine, Triamine andSchiff Base Derivatives and Their Copper(II) Complexes (1998)

Ethylenediamine (en), putrescine (pu), diethylenetriamine (dien), dipropylenetriamine (dpta), spermidine (spmd) and their Cu(II) compounds as well as the Schiff bases with 2-furaldehyde (dienOO), 2- thiophenecarboxaldehyde (dienSS) and pyrrole-2-carboxaldehyde (dienNN) of dien and that of dpta with 2- thiophenecarboxaldehyde (dptaSS), were prepared and characterised. They were tested against Bacillus substilis, Bacillus cereus, Staphylococcus aureus, Escherichia coli, Proteus vulgaris and Xanthomonas campestris as antibacterial reagents, the highest activity being exhibited by Cu(dptaSS)(NO(3))(2) complex, which acts as antibiotic. In the antiproliferative tests (vs. T(47)D,L(929) and BHK(21/c13) cell lines) the best results were obtained with Cu(dptaSS)(2+) and Cu(dienSS)(2+). Electronic structure calculations gave for dptaSS and dienSS the higher negative charges on the N atoms. The counter-ions (Br(-), NO(3) (-) and SO(4) (2-)) play an important role by modulating the reagent's selectivity versus the bacteria [Gram(+) or Gram(-)], but they have no effect on the antiproliferative activity.
A Numerical Model for Freeze Drying Processes with Infrared Radiation Heating (2010)

A numerical model has been developed for accurate prediction of freeze drying processes subjected to infrared radiation heating. A spectral two-flux radiation model was incorporated into freeze drying analysis to consider the spectral absorption characteristics of moisture-rich products. The temperature of the infrared heater was found to significantly influence the freeze drying behaviors. At a fixed intensity level at the product surface, a higher heater temperature increased the drying time while temperature in the product was significantly reduced. This result was discussed in relation with the spectral composition of light emitting from infrared heaters.
Measurement of Broensted acid and Lewis acid strength distributions of solid acid catalysts using chemisorption isotherms of Hammett indicators (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMeasurement of Broensted acid and Lewis acid strength distributions of solid acid catalysts using chemisorption isotherms of Hammett indicatorsKenji Hashimoto, Takao Masuda, and Hideki SasakiCite this: Ind. Eng. Chem. Res. 1988, 27, 10, 1792–1797Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/ie00082a010https://doi.org/10.1021/ie00082a010research-articleACS PublicationsRequest reuse permissionsArticle Views365Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts