gebhart/patrepeval huggingface dataset:
Expression of osteopontin in calcified coronary atherosclerotic plaques (2000)

Advanced atherosclerosis is often associated with dystrophic calcification and remodeling of extracellular matrix of vascular wall. Recently many studies have documented a general relationship between calcification and severity of coronary disease, and discussed the feasibility of electron beam computed tomography for detecting and quantifying the coronary artery calcification in the patients. The present study investigated the expression and the localization of osteopontin, one of noncollagenous bone matrix protein, within the calcified coronary arteries. Autopsy-derived coronary artery specimens were scanned and reconstructed to visualize the pattern of coronary calcification using a novel microscopic computed tomography technique. The localization of the osteopontin were evaluated by immunohistochemial stain with LF7. The present study showed that the pattern of coronary calcification is variable and the expression of osteopontin is localized mainly to calcified lesion. The smooth muscle cells in addition to macrophage expressed osteopontin protein in human coronary atherosclerotic plaques. Soluble osteopontin released near to the sites of vascular calcification may represent an adaptive mechanism aimed at regulating the process of vascular calcification.
Aminolysis of Esters or Lactones Promoted by NaHMDS - A General and Efficient Method for the Preparation of N-Aryl Amides (2001)

An efficient method for the preparation of N-aryl amides from anilines, esters or lactones promoted by NaHMDS is described. Advantages of this new method include high yields and mild reaction conditions which tolerate functional groups such as ketones and halides.
In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles (2010)

We report protoporphyrin IX (PpIX) encapsulated pH-responsive micelles for cancer treatment. This system showed pH-responsive micellization/demicellization transition at tumoral acidic pH and enabled in vivo tumor diagnosis and therapy simultaneously.
Organic Chemistry of Polyanilines: Tailoring Properties to Technological Applications~!2008-08-19~!2008-09-11~!2008-11-28~! (2008)

The use of organic chemistry reactions to introduce additional functional groups on polyanilines is described. Among the reactions discussed are: electrophilic aromatic substitution, nucleophilic addition to the aromatic rings, nucleophilic substitution on the amine groups and reactions on pendant groups. The use of combinatorial chemistry techniques, by coupling of combinatorially synthesised diazonium salts with polyaniline, to produce a functionalized polyanilines library is also reviewed. The modification of polyaniline introduces or alters different properties of the materials: solubility, self-doping and redox coupled ion exchange. The tailoring of those properties to technical applications is therefore examined.
Hankel Matrix Rank Minimization with Applications to System Identification and Realization (2013)

We introduce a flexible optimization framework for nuclear norm minimization of matrices with linear structure, including Hankel, Toeplitz, and moment structures and catalog applications from diverse fields under this framework. We discuss various first-order methods for solving the resulting optimization problem, including alternating direction methods of multipliers, proximal point algorithms, and gradient projection methods. We perform computational experiments to compare these methods on system identification problems and system realization problems. For the system identification problem, the gradient projection method (accelerated by Nesterov's extrapolation techniques) and the proximal point algorithm usually outperform other first-order methods in terms of CPU time on both real and simulated data, for small and large regularization parameters, respectively, while for the system realization problem, the alternating direction method of multipliers, as applied to a certain primal reformulation, usually outperforms other first-order methods in terms of CPU time. We also study the convergence of the proximal alternating direction methods of multipliers used in this paper.
The Legal Aspects of Municipal Fluoridation of Water (1957)

34 See, in that connection, the case of Beach v
High-surface-area zeolitic silica with mesoporosity (2001)

In this study, we report a new, simple approach to the preparation of high-surface-area zeolitic silica (HZS) with well-defined mesoporosity by combining hydrothermal synthesis and sol–gel processing. N2 adsorption–desorption measurements show that HZS has a BET surface area of 678–723 m2 g−1 and well-defined bimodal pores at 5.5 and 26.0–34.5 Å. XRD, TEM and FT-IR show that HZS has a typical zeolite MFI structure. HZS is thermally stable and has tunable pore size and pore volume, and thus is promising for applications in catalysis, separation, and microelectronics. The described approach also appears general and may be readily extended to zeolitic aluminosilicates by using suspensions of other zeolite nanoparticles.
Design of new conducting 3,4-disubstituted polythiophenes (1990)

Chemical oxidation of 3,4-dialkylthiophenes gave non-planar polymers exhibiting reduced conductivities; however, decreasing the steric hindrance, by using alkoxy derivatives, led to the synthesis of soluble and highly conducting disubstituted polythiophenes.
Prevalence of AD among whites (2000)

With disease severity taken into account, estimates of AD prevalence from white populations are more consistent than is usually acknowledged. By including disease severity in the case definition, variations in reported rates are much reduced. The outlier status of the East Boston study appears to result from the use of a definition of AD that differs from that used in the other 20 studies. Alternative explanations of the discrepancy between these estimates and the common estimate of 4 million cases are discussed.
Properties of Microstrip Line on Si-SiO/sub 2/ System (1971)

A parallel-plate waveguide model for the microstrip line formed on the Si-SiO/sub 2/ system is analyzed theoretically and the results are compared with the experiment. The experiment has been performed over wide ranges of frequency, substrate resistivity, and strip width. Existence of three types of fundamental modes is concluded and the condition for the appearance of each mode is clarified. In particular, the slow-wave mode is found to propagate within the resistivity-frequency range suited to the monolithic circuit technology, and its propagation mechanism is discussed. Approximate analysis of the fringing effect is also made for the slow-wave mode.
Word-Based Models (2009)

In this chapter, we discuss word-based models. The models stem from the original work on statistical machine translation by the IBM Candide project in the late 1980s and early 1990s. While this approach does not constitute the state of the art anymore, many of the principles and methods are still current today.
Enterovirus infection can induce immune responses that cross‐react with β‐cell autoantigen tyrosine phosphatase IA‐2/IAR (2002)

Insulin-dependent (type 1) diabetes is characterized by progressive destruction of insulin-producing beta cells probably by autoreactive T lymphocytes. Viral infections, especially those caused by coxsackieviruses, are postulated to play a role in the pathogenesis of the disease in humans. One mechanism by which viral infections could initiate or accelerate diabetogenic processes is "molecular mimicry," induction of antiviral immune responses cross-reacting with epitopes in the beta-cell autoantigens. Tyrosine phosphatases (IA-2, IAR) represent a major target autoantigen in type 1 diabetes. Both humoral and cellular immune responses are directed to the carboxy-terminal (C-terminal) part of the protein. This region has a 5-amino acid sequence identity, followed by five amino acid similarity with the conservative motif in the VP1-protein of enteroviruses (PALTAVETGA/HT), which is a highly immunogenic B- and T-cell epitope in enterovirus infection-induced immune responses. This observation prompted us to investigate potential humoral cross-reactions between immune responses induced by tyrosine phosphatases and enteroviruses. The reactivities of various peptide- and virus-induced rabbit antisera clearly demonstrated that cross-reactions do exist, and in both directions. Using epitope mapping, we were able to show that several diabetes-linked epitopes in IA-2 were also recognized by CBV-4-induced antisera. Immunization of female NOD-mice with formalin-inactivated purified strain of coxsackievirus B4 (CBV-4-E2) induced an immune response that recognized the IA-2/IAR diabetogenic peptide. The results obtained with human paired sera, collected during enterovirus infection, indicated that enterovirus infection in humans may also occasionally induce a humoral response that cross-reacts with IA-2/IAR.
Involvement of nitric oxide in the regulation of gonadotropin-releasing hormone release from the GT1-1 neuronal cell line. (1994)

A role for nitric oxide (NO) in the regulation of hypothalamic neurohormone secretion has been suggested. The aim of the present study was to establish a direct involvement of this novel intracellular regulatory molecule in the control of GnRH release. For this purpose, the GT1-1 GnRH-secreting continuous cell line was treated with various agents that can modify the endogenous NO synthase activity or, alternatively, with substances that can liberate NO, mimicking an increased concentration of this molecule in the cell. Treatment of GT1-1 cells with increasing concentrations of L-arginine, the direct precursor of NO, produced a marked reduction of norepinephrine-stimulated GnRH release despite a lack of effect on basal secretion. Similarly, the NO donors SIN-1 and acidified NaNO2 potently reduced basal as well as KCl-stimulated GnRH secretion. Conversely, sodium nitroprusside caused a significant inhibition of KCl-stimulated, but not basal, GnRH secretion. Addition of these agents to GT1-1 cells resulted in a marked increase in intracellular cGMP accumulation. Addition of the NO synthase inhibitors N-nitro-L-arginine and N-nitro-L-arginine methyl ester stimulated basal GnRH secretion without modifying norepinephrine- or KCl-stimulated release. In addition, treatment of GT1-1 cells with both L-arginine analogs produced a significant inhibition of the basal cGMP concentration. Together, these data suggest an inhibitory role for NO in the control of GnRH secretion from GT1-1 cells.
Implementation of a closed-loop CD and overlay controller for sub-0.25-μm patterning (1998)

The traditional approach for CD and overlay control in lithography has been based upon statistical control of the critical inputs to the lithographic process. This SPC approach has the disadvantage that the process equipment must be taken out of manufacturing whenever a parameter goes out of control, so that the root cause may be diagnosed and addressed. In the case of leading-edge lithography, it is often not trivial to determine the cause of such disturbances, and productivity can be greatly increased if output data is used to dynamically tune the system inputs. We have successfully implemented a fully automated, closed-loop CD and overlay control system in manufacturing for both I-line and DUV lithography. This system features automatic metrology data upload, host control of stepper/track clusters, and utilizes tool-based lot data for manipulation of future lot inputs. CD control to within 1 nm of target and less than 20 nm 3(sigma) lot to lot variability has been demonstrated. Mean overlay errors of less than 50 nm have been realized as well. Process C<SUB>pk</SUB> values were improved in some cases by more than 50% with implementation of the controller.
Phase ii evaluation of a combination of mitomycin C, vincristine, and cisplatin in advanced non-small cell lung cancer (1986)

The combination treatment of mitomycin C (M), vincristine (V), and cisplatin (P) (MVP) in 63 patients with advanced non-small cell lung cancer (NSCLC) were evaluated for their potential synergistic cytotoxicity. The overall response rate was 43% (27/63); in the 54 eligible and evaluable patients, the response rate was 50% (27/54). Responses were observed in all cell types and disease sites. Cell type; performance status of 0, 1, or 2; sex; and age younger or older than 60 years did not significantly influence the response rate. However, patients with prior radiation had significantly more treatment failure than those without. The dose-limiting side effects in these 54 patients were myelosuppression (40%), pulmonary fibrosis (9%), peripheral neuropathy (6%), and intractable nausea and vomiting (4%). The degree of leukopenia (P less than 0.01) but not of thrombocytopenia increased significantly in patients who had received prior radiotherapy. One patient died of marked thrombocytopenia and one of fulminant hepatitis. Patients who responded lived significantly longer than those who did not (P less than 0.004). A majority of the responders (82%) also achieved symptomatic palliation. With appropriate dose modification and supportive care, MVP was tolerable. Further trials with this regimen or a modified version are worth consideration.
Clearance of Amyloid-β Peptide Across the Choroid Plexus in Alzheimers Disease (2010)

Aging and several neurodegenerative diseases bring about changes in the anatomy and physiology of the choroid plexus. The identification of specific membrane receptors that bind and internalize extracellular ligands has revolutionized the traditional roles of this tissue. Amyloid beta peptide (Aβ), the major constituent of the amyloid core of senile plaques in patients with Alzheimer's disease (AD) is known to contribute to disease neuropathology and progression. Recent emphasis on comorbidity of AD and a deficient clearance of Aβ across the blood-brain barrier and blood-cerebrospinal fluid barrier have highlighted the importance of brain Aβ clearance in AD. The megalin receptor has also been implicated in the pathogenesis of AD. Faulty Aβ clearance from the brain across the choroid plexus epithelium by megalin appears to mediate focal Aβ accumulation in AD. Patients with AD have reduced levels of megalin at the choroid plexus, which in turn seem to increase brain levels of Aβ through a decreased efflux of brain Aβ. Therapies that increase megalin expression at the choroid plexus could potentially control accumulation of brain Aβ. This review covers in depth the anatomy and function of the choroid plexus, focusing on the brain barrier at the choroid plexus, as it actively participates in Aβ clearance. In addition, we describe the role of the choroid plexus in brain functions, aging and AD, as well as the role of megalin in the process of Aβ clearance. Finally, we present current data on the use of choroid plexus cells to repair the damaged brain.
Arsenic(III) Oxidation and Arsenic(V) Adsorption Reactions on Synthetic Birnessite (2002)

The oxidation of arsenite (As(III)) by manganese oxide is an important reaction in both the natural cycling of As and the development of remediation technology for lowering the concentration of dissolved As(III) in drinking water. This study used both a conventional stirred reaction apparatus and extended X-ray absorption fine structure (EXAFS) spectroscopy to investigate the reactions of As(III) and As(V) with synthetic birnessite (MnO2). Stirred reactor experiments indicate that As(III) is oxidized by MnO2 followed by the adsorption of the As(V) reaction product on the MnO2 solid phase. The As(V)-Mn interatomic distance determined by EXAFS analysis for both As(III)- and As(V)-treated MnO2 was 3.22 A, giving evidence for the formation of As(V) adsorption complexes on MnO2 crystallite surfaces. The most likely As(V)-MnO2 complex is a bidentate binuclear corner sharing (bridged) complex occurring at MnO2 crystallite edges and interlayer domains. In the As(III)-treated MnO2 systems, reductive dissolution of the MnO2 solid during the oxidation of As(III) caused an increase in the adsorption of As(V) when compared with As(V)-treated MnO2. This suggested that As(III) oxidation caused a surface alteration, creating fresh reaction sites for As(V) on MnO2 surfaces.
연구논문 : 해저퇴적물 입도분석 시스템의 자동화에 대한 연구 (1994)

A combination of sieving (for sand) and hydrometer analysis (for silt and clay) is routinely used to study soil and marine sediments. In this study an electronic hydrometer is developed to obtain and store raw data automatically with a PC for hydrometer analysis. A variation of 4$quot;-stroke LVDT (Linear Variable Differential Transformer) is used as an electronic hydrometer- The output signal is converted to digital data by using an 8-bit A/D converter and stored into the PC. The stored data is analysed to compute grain-size statistics, and print a cumulative curve and histogram of class weight percent vs. phi class interval. The grain-size statistics, then, are applied to study direction of sediment transport energy distribution at nearshore environments. With the help of automatic data acquisition and data analysis system a great effort on hydrometer analysis can be reduced without sacrificing accuracy.
Using Exercise Testing to Document Functional Disability in CFS (1995)

No abstract available for this article.
Genomic analysis of two GB virus A variants isolated from captive monkeys. (1998)

The recent isolation of GB viruses A and B from GB agent infected tamarins and their lack of involvement in human hepatitis has sparked interest in the origin of these viruses. Several healthy non-human primate species have been shown to harbour sequences 52-79% identical to the GBV-A 5' nontranslated region. In this paper we report the near genome length sequence of GBV-Amx 70047 and GBV-Atri 1122. These sequences support previous observations about the genomic organization of GBV-A and provide insight into the genomic variability within this virus genus. Although the GBV-A variant polyproteins possess many motifs conserved between other members of the Flaviviridae, they do not encode a basic core-like protein. Amino acid sequence comparisons and phylogenetic analysis demonstrate variability within the GBV-A genus similar to that observed between hepatitis C virus (HCV) types. However, genomic organization and disease association demonstrate a closer evolutionary relationship to GBV-C than to HCV.
Recent advances in the treatment of multiple myeloma (1998)

Multiple myeloma represents the second most common hematologic malignancy, with nearly 15,000 new cases each year in the United States. Although further understanding of the pathogenesis of this B-cell malignancy has been made, the disease remains incurable with a median survival of approximately 3 years. The identification of new genetic events in the malignant cells themselves may lead to new potential therapies. Moreover, recent identification of the new human herpesvirus 8 in the supporting cells of the bone marrow of these patients will likely change approaches to this disease in the laboratory and the clinic. Further development of new high-dose therapy approaches has led to a reduction in treatment-related mortality with an improvement in overall survival. Treatment with the bisphosphonate pamidronate reduces skeletal complications and may also improve overall survival of these patients.
<i>S </i>‐Stereoselective piperazine‐2‐<i>tert</i>‐butylcarboxamide hydrolase from <i>Pseudomonas azotoformans</i> IAM 1603 is a novel <scp>l</scp>‐amino acid amidase (2004)

An amidase acting on (R,S)-piperazine-2-tert-butylcarboxamide was purified from Pseudomonas azotoformans IAM 1603 and characterized. The enzyme acted S-stereoselectively on (R,S)-piperazine-2-tert-butylcarboxamide to yield (S)-piperazine-2-carboxylic acid. N-terminal and internal amino acid sequences of the enzyme were determined. The gene encoding the S-stereoselective piperazine-2-tert-butylcarboxamide amidase was cloned from the chromosomal DNA of the strain and sequenced. Analysis of 2.1 kb of genomic DNA revealed the presence of two ORFs, one of which (laaA) encodes the amidase. This enzyme, LaaA is composed of 310 amino acid residues (molecular mass 34 514 Da), and the deduced amino acid sequence exhibits significant similarity to hypothetical and functionally characterized proline iminopeptidases from several bacteria. The laaA gene modified in the nucleotide sequence upstream from its start codon was overexpressed in Escherichia coli. The activity of the recombinant LaaA enzyme in cell-free extracts of E. coli was 13.1 units.mg(-1) with l-prolinamide as substrate. This enzyme was purified to electrophoretic homogeneity by ammonium sulfate fractionation and two column chromatography steps. On gel-filtration chromatography, the enzyme appeared to be a monomer with a molecular mass of 32 kDa. It had maximal activity at 45 degrees C and pH 9.0, and was completely inactivated in the presence of phenylhydrazine, Zn2+, Ag+, Cd2+ or Hg2+. LaaA had hydrolyzing activity toward L-amino acid amides such as L-prolinamide, L-proline-p-nitroanilide, L-alaninamide and L-methioninamide, but did not act on the peptide substrates for the proline iminopeptidases despite their sequence similarity to LaaA. The enzyme also acted S-stereoselectively on (R,S)-piperidine-2-carboxamide, (R,S)-piperazine-2-carboxamide and (R,S)-piperazine-2-tert-butylcarboxamide. Based on its specificity towards L-amino acid amides, the enzyme was named L-amino acid amidase. E. coli transformants overexpressing the laaA gene could be used for the S-stereoselective hydrolysis of (R,S)-piperazine-2-tert-butylcarboxamide.
Transform coding algorithms for seismic data compression (2002)

An investigation is presented of transform-based seismic data compression. The study concentrates on discrete orthogonal transforms such as the discrete Fourier transform (DFT), the discrete cosine transform (DCT), the Walsh-Hadamard transform (WHT), and the Karhunen-Loeve transform (KLT). Uniform and subband transform coding schemes were implemented, and comparative results are given for data rates ranging from 150 to 550 b/s. These results are also compared to existing linear prediction techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Solubilities of Nickel Oxide in Molten Carbonate (1992)

Cathode dissolution is a major problem for the development of the molten carbonate fuel cell. In order to evaluate the stability of the cathode, the solubility of has been measured for several compositions of molten alkaline carbonates in the pressure range from 10−5 to 1 atm and the temperature range from 873 to 1023 K. The solubility depended on the pressure, although the solubility of was independent of either or pressure. In any composition of the Li/K and Li/Na carbonate melts, the acid dissolution has been observed at higher pressure and the basic dissolution has been observed at low pressure. was found to be more stable in Li rich or Li/Na melts than in the Li/K eutectic melt.
[Effect of small interfering RNA targeting p63 on the proliferation and invasiveness of human cholangiocarcinoma cells in vitro]. (2012)

Down-regulation of p63 can inhibit the proliferation and invasiveness of human cholangiocarcinoma QBC939 cells in vitro.