gebhart/patrepeval huggingface dataset:
Algorithm 573: NL2SOL—An Adaptive Nonlinear Least-Squares Algorithm [E4] (1981)

article Free AccessArtifacts AvailableArtifacts Evaluated & ReusableAlgorithm 573: NL2SOL—An Adaptive Nonlinear Least-Squares Algorithm [E4] Authors: John E. Dennis Department of Mathematical Sciences, Rice University, P.O. Box 1892, Houston, TX Department of Mathematical Sciences, Rice University, P.O. Box 1892, Houston, TXView Profile , David M. Gay M.I.T./CCREMS, Room E53-383, Cambridge, MA M.I.T./CCREMS, Room E53-383, Cambridge, MAView Profile , Roy E. Welsch M.I.T./CCREMS, Room E53-383, Cambridge, MA M.I.T./CCREMS, Room E53-383, Cambridge, MAView Profile Authors Info & Claims ACM Transactions on Mathematical SoftwareVolume 7Issue 3Sept. 1981 pp 369–383https://doi.org/10.1145/355958.355966Published:01 September 1981Publication History 274citation4,068DownloadsMetricsTotal Citations274Total Downloads4,068Last 12 Months180Last 6 weeks64 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
VEGAS' NEXT HIGH ROLLER: A MONORAIL. (2002)

Western cities look at public transit as road gridlock worsens. This article looks at plans for the Las Vegas monorail that will zip through the heart of the Strip, curving along elevated tracks that rise 50 feet above the ground and dim their lights at night so passengers see the city flash by in all of its neon splendor. The monorail which serves the Strip, will extend seven miles by the time construction ends later this decade.
Technical Note on Renal Angioplasty and Stenting: New Developments that Facilitate Its Performance (2004)

Technologic advances in percutaneous catheter-based therapy for renovascular occlusive disease have resulted in progressively miniaturized wires, balloon catheters, stents, and delivery systems. The technique of angioplasty and stenting of renal artery stenoses has been shown to be a safe and effective option for severe hypertension and ischemic nephropathy. Renal artery stenting, especially when performed with the newer lower-profile systems, can be performed with minimal morbidity and a reliably high degree of initial technical success. In this article, we describe our technique using a lower-profile platform of balloons and stents and review data supporting renal artery stenting.
Automatic Web Service Composition with a Heuristic-Based Search Algorithm (2011)

Service Oriented Architectures and web service technology are becoming popular in recent years. As more web services can be used over the Internet, the need to find efficient algorithms for web services composition that can deal with large amounts of services becomes important. These algorithms must deal with different issues like performance, semantics or user restrictions. In this paper we present an A* algorithm which solves the problem of semantic input-output message structure matching for web service composition. Given are quest, a service dependency graph with a subset of the original services from an external repository is dynamically generated. Then, the A* search algorithm is used to find a minimal composition that satisfies the user request. Moreover, in order to improve the performance, a set of dynamic optimization techniques has been implemented over the search process. A full experimental validation with eight different public repositories has been done showing a good performance as in all tests as the algorithm finds a valid solution with minimal number of services and execution path.
Cell‐mediated immunity to polio and HLA antigens in amyotrophic lateral sclerosis (1979)

Cell-mediated immunity to poliovirus was demonstrated in 21 of 33 patients suffering from amyotrophic lateral sclerosis (ALS), whereas no response to poliovirus was found in patients suffering from other neurologic disorders or in healthy controls. Three of the severe bulbar cases produced a migration inhibition factor (MIF) in the presence of poliovirus, although skin tests to common antigens were negative. An increased incidence (46 percent) of HLA-A3 was found in patients with amytrophic lateral sclerosis. Nine of the 13 patients with HLA-A3 antigen also had a positive index of MIF to poliovirus. These findings suggest a strong linkage between HLA-A3 and poliovirus in the pathogenesis of amyotrophic lateral sclerosis.
Roles of Ca2+ and F-actin in intracellular aggregation of Chlamydia trachomatis in eucaryotic cells (1993)

The effect of intracellular free Ca2+ ([Ca2+]i) on the intracellular aggregation of Chlamydia trachomatis serovars L2 and E in McCoy and HeLa cells is investigated. Loading the cells with the Ca2+ chelator MAPT/AM (1,2-bis-5-methyl-amino-phenoxylethane-N,N-n'-tetra-acetoxymethyl acetate), thereby decreasing the [Ca2+]i from 67 to 19 nM, decreased the number of cells with a local aggregation of chlamydiae in a dose-dependent manner. Neither the attachment nor the uptake of elementary bodies (EBs) was, however, affected after depletion of Ca2+ from the cells. There was no significant difference in the level of measured [Ca2+]i between infected and uninfected cells. Reducing the [Ca2+]i also significantly inhibited chlamydial inclusion formation. Differences in the organization of the actin filament network were observed in response to [Ca2+]i depletion. In Ca(2+)-depleted cells, where few EB aggregates were formed, few local accumulations of F-actin were observed in the cytosol. These results suggest that the aggregation of EBs in eucaryotic cells requires a normal homeostasis of intracellular Ca2+. By affecting F-actin reorganization and putatively certain Ca(2+)-binding proteins, [Ca2+]i plays a vital role in the infectious process of chlamydiae.
Isomer Energy Source in Hybrid Jet Engines for High Altitude Reconnaissance Flight (2004)

An investigation was performed on the possibility of employing a triggered isomer heat exchanger (TIHE) as part of a hybrid heat source in an otherwise conventional turbojet engine. Reported is the application of such a long duration engine in a high-altitude long endurance surveillance and reconnaissance mission. Two-phase operation would include a switchover point, that is, an altitude and Mach number at which conventional combustion is replaced by the TIHE. A comparison of conventional and hybrid engines indicates a hybrid mixed-stream turbofan engine flying a part conventional and part TIHE mission, with a switchover at a Mach number of 0.4 at 40,000 ft, could provide weeks of endurance. Takeoff weight would be reduced by 20% due to lower fuel requirements.
Characterizations of Cold‐sprayed TiN Particle‐reinforced Al Alloy‐based Composites – from Structures to Tribological Behaviour (2007)

Dense Al5356/TiN composites, with a porosity less than 1%, were successfully produced by cold spraying (CS) of mechanically blended powders. The effect of TiN volume fraction in the composite on the microstructure and tribological performance of CS Al5356/TiN were examined. It was found that TiN particles were uniformly dispersed in the matrix. Compared to pure Al5356 deposit, the composites exhibit a decreasing porosity. With increasing TiN volume fraction in the blend, TiN volume fraction in the composite increases correspondingly. The incorporation of TiN particles increases effectively the microhardness, adhesive strength and tribological performance of the composite. The catastrophic wear rate caused by the prominent adhesion force between the two sliding pairs, occurring in the case of pure Al5356, can be avoided by the incorporation of TiN particles.
Exploiting Virtual Synchrony in Distributed Systems (1987)

We de•crib• applications of • virtually synchronous environment for distributed prolpamming, which underlies a collection of' distributed programming tools in the ISIS_ system.A virtually synchronous environment • Slows processes to be structured into proceu groups, and m•kso events like brondcants to the group as an entity, group membership changes, and even migration oF sn activity From one place to another appear to occur ins•an.tanecusly in other words, synchronously.A rngjor advantage to this approach i8 that many upects of" • distributad application can be treated independently without compromising correctness.Moreover, user cede that is designed as if the system were synchronous can o/tan be executed concurrently.We argue that this approach to building distributed and fault.tolerantso/•war• is more straightforward, more.flexible, and more likely to yield correct solutions than alternative approaches.I, A toolkit for distributed systems Consider the design of a distributed system for factory automation, say for VLSI chip fabrication.Such a system would need to group control processes into services responsible for different aspects of the fabrication procedure.One service might accept batches of chips needing photographic emulsions, another oversee transport of ch/ps from station to station, etc.Within a service, algorithms would be needed for scheduling work, replicating data, coordi.
Covalent binding of the endogenous estrogen 16 alpha-hydroxyestrone to estradiol receptor in human breast cancer cells: characterization and intranuclear localization. (1988)

The interactions of 16 alpha-hydroxyestrone (16 alpha-OHE1), a metabolite of estradiol (E2), with estrogen receptors (ERs) were compared in this study to the classic E2-receptor mechanism in human breast cancer cells MCF-7 in culture. When MCF-7 cells were incubated with radioinert 16 alpha-OHE1 or its 3H-labeled form for 4 weeks, the estrogen bound extensively and irreversibly in a time-dependent fashion to nuclear protein species that correspond to the ER. Here we show that the interactions of 16 alpha-OHE1 with the ER are different from those of E2 with the receptor. Dissociation of tritiated E2-ER or 16 alpha-OHE1-ER complexes, salt extraction, DNase and proteinase K digestion, and ethanol treatment demonstrated that the binding of 16 alpha-OHE1 to the ER corresponds to two different forms: a classical noncovalent interaction similar to that of E2, and a covalent adduct formation between the metabolite and the ER. These complexes localized preferentially in nuclear matrix components as revealed by cell fractionation and probing with a monoclonal anti-ER antibody. [3H]16 alpha-OHE1-ER complexes analyzed by polyacrylamide gel electrophoresis demonstrated a radiolabeled band at approximately 66 kDa that was absent when the exposure of cells was done in the presence of E2 in competition and that was also absent in [3H]E2 incubations. The present results when considered together with our previous findings of elevated activities of estrogen 16 alpha-hydroxylase, the enzyme responsible for the formation of 16 alpha-OHE1, in breast cancer patients and in women at enhanced risk for the disease, suggest that covalent modification of the ER may be one mechanism of malignant transformation in estrogen target tissues.
SPADES: a simulator for path delay faults in sequential circuits (1992)

A fault simulator for path delay faults in synchronous sequential circuits is described, where a test sequence is considered under different combinations of slow and fast clock cycles (clocking schemes). The features of the simulator are: (1) multiple clocking schemes used for the application of a given test sequence are considered in parallel, allowing fast fault simulation for a given sequence, to obtain the highest fault coverage achieveable by every sequence; (2) during the simulation process, it is possible to determine the clocking scheme so as to minimize the number of different clocking schemes to be used with the sequence, without compromising the fault coverage; and (3) a path representation scheme that allows efficient access to path delay faults detected by previous tests is used. Experimental results are presented to demonstrate these features and their effectiveness. >
Noncovalent Functionalization of Graphite and Carbon Nanotubes with Polymer Multilayers and Gold Nanoparticles (2003)

This paper describes a strategy for functionalizing graphite and carbon nanotube surfaces with multilayered polymeric films. Poly(amphiphiles) adsorb noncovalently onto these surfaces from aqueous solutions, due to hydrophobic interactions. The covalent attachment of a second polymer layer to this initial adsorbed layer results in the formation of a cross-linked polymer bilayer; additional layers can be deposited by the covalent or electrostatic attachment of polyelectrolytes. We used these multilayered polymer films to mediate the attachment of gold nanoparticles to graphite, single-walled nanotube (SWNT), and multiwalled nanotube (MWNT) surfaces. This approach provides a convenient method for attaching other nanostructures, biological molecules, or ligands to carbon nanotubes.
Screening of differentially expressed genes in rat hearts after hemorrhagic shock with suppression subtractive hybridization (2002)

Objective To investigate genetic clues to reveal the mechanisms of severe heart injuries caused by hemorrhagic shock, especially by hypoxia and ischemia in rats. Methods Hemorrhagic shock rat models were established and total RNA were extracted from rat hearts. After the synthesis of the dscDNA, differentially expressed genes was isolated with suppression subtractive hybridization (SSH). Then the isolated genes were cloned and sequenced. The sequencing results were compared with their counterparts in Genbank to search for their homology. Results Among the 42 obtained positive genes, 25 were highly expressed and 17 lowly. Additionally, 5 new sequences were found. Conclusion SSH is an effective method to isolate differentially expressed genes. Hemorrhagic shock changes the expressions of some genes in rat heart, such as Rat 45S rDNA gene transcription initiation region, Rattus norvegicus cysteine rich protein 61 and Rattus norvegicus serum inducible kinase (Snk). But the relation between these genes and the injuries needs further study.
Kinematic analysis of over-determinate biomechanical systems (2008)

In this paper, we introduce a new general method for kinematic analysis of rigid multi body systems subject to holonomic constraints. The method extends the standard analysis of kinematically determinate rigid multi body systems to the over-determinate case. This is accomplished by introducing a constrained optimisation problem with the objective function given as a function of the set of system equations that are allowed to be violated while the remaining equations define the feasible set. We show that exact velocity and acceleration analysis can also be performed by solving linear sets of equations, originating from differentiation of the Karush-Kuhn-Tucker optimality conditions. The method is applied to the analysis of an 18 degrees-of-freedom gait model where the kinematical drivers are prescribed with data from a motion capture experiment. The results show that significant differences are obtained between applying standard kinematic analysis or minimising the least-square errors on the two fully equivalent 3D gait models with only the way the experimental data is processed being different.
Novel Cell-Free Strategy for Therapeutic Angiogenesis: In Vitro Generated Conditioned Medium Can Replace Progenitor Cell Transplantation (2009)

Intramuscular injection of EPC-CM is as effective as cell transplantation for promoting tissue revascularization and functional recovery. Owing to the technical and practical limitations of cell therapy, cell free conditioned media may represent a potent alternative for therapeutic angiogenesis in ischemic cardiovascular diseases.
Structure of N‐glycosidic Carbohydrates of Secretory Proteins of <i>Tetrahymena thermophila</i> (2003)

Glycoproteins secreted by Tetrahymena into the culture medium were isolated and the N-glycosidic oligosaccharides analyzed using lectin blots and fluorophore-assisted carbohydrate gel electrophoresis (FACE). Lectin blots showed that the glycoproteins secreted by Tetrahymena contain only N-glycosidic structures of the high mannose type. Further analysis using the FACE technology revealed the presence of four different N-glycosidic structures differing only in the number of mannose residues attached to the core chitobiose unit.
Central pain (1995)

The pathophysiology of central pain (CP) remains poorly understood.The paucity of objective findings on clinical examination of some of these patients can add to the difficulty in establishing a concrete diagnosis of CP. A pathophysiologic conceptual framework has been established to provide guidance. The goal of treatment should be pain reduction rather than complete pain relief. Surgical procedures have been used for specific causes of CP, but no one surgical technique helps relieve pain over the long term in all CP patients. Likewise, no one pharmacologic agent is successful in all CP patients, and pain relief is often incomplete. Pharmacologic treatment may take the form of stepwise addition of various agents, the cornerstone of which are antidepressants, followed by anticonvulsants, opioids, and other drugs. If all standard pharmacologic treatments fail, treatment of psychological problems induced by chronic pain is necessary since depression and the risk of suicide are significant in patients with poorly controlled CP. <b>NEUROLOGY 1995;45(suppl 9): </b> S11-S16
Query by humming: matching humming query to polyphonic audio (2003)

Previously a great attention has been paid to content-based multimedia retrieval that enables users to find and locate audio-visual material according to the intrinsic characteristics of the target. Query by humming (QBH) is also an application that makes retrieval according to major characteristics of music, that is, "melody". Our focus is on the realization of query-by-humming technology for easy-to-use application, which entails full automation of all the processes of the system, including melody information extraction from polyphonic audio. This paper presents developed algorithms for key steps of a QBH system including the melody feature extraction method from polyphonic audio and humming, their representation for matching, and matching method between the represented melody information from polyphonic audio and humming.
Light-scattering flow cytometry for identification and characterization of blood microparticles (2012)

We describe a novel approach to study blood microparticles using the scanning flow cytometer, which measures light scattering patterns (LSPs) of individual particles. Starting from platelet-rich plasma, we separated spherical microparticles from non-spherical plasma constituents, such as platelets and cell debris, based on similarity of their LSP to that of sphere. This provides a label-free method for identification (detection) of microparticles, including those larger than 1 μm. Next, we rigorously characterized each measured particle, determining its size and refractive index including errors of these estimates. Finally, we employed a deconvolution algorithm to determine size and refractive index distributions of the whole population of microparticles, accounting for largely different reliability of individual measurements. Developed methods were tested on a blood sample of a healthy donor, resulting in good agreement with literature data. The only limitation of this approach is size detection limit, which is currently about 0.5 μm due to used laser wavelength of 0.66 μm.
Measurements on the velocity/field characteristic of indium phosphide (1971)

The velocity/field characteristic of InP has been found for fields between 14 and 32 kV/cm from space-charge-wave amplification, and between 32 and 200 kV/cm from measurements on dipole domains. The threshold field (12–13 kV/cm) and the maximum negative differential mobility (1000 cm2/Vs) are compared with theory.
Selective Area Growth of Well-Ordered ZnO Nanowire Arrays with Controllable Polarity (2014)

Controlling the polarity of ZnO nanowires in addition to the uniformity of their structural morphology in terms of position, vertical alignment, length, diameter, and period is still a technological and fundamental challenge for real-world device integration. In order to tackle this issue, we specifically combine the selective area growth on prepatterned polar c-plane ZnO single crystals using electron-beam lithography, with the chemical bath deposition. The formation of ZnO nanowires with a highly controlled structural morphology and a high optical quality is demonstrated over large surface areas on both polar c-plane ZnO single crystals. Importantly, the polarity of ZnO nanowires can be switched from O- to Zn-polar, depending on the polarity of prepatterned ZnO single crystals. This indicates that no fundamental limitations prevent ZnO nanowires from being O- or Zn-polar. In contrast to their catalyst-free growth by vapor-phase deposition techniques, the possibility to control the polarity of ZnO nanowires grown in solution is remarkable, further showing the strong interest in the chemical bath deposition and hydrothermal techniques. The single O- and Zn-polar ZnO nanowires additionally exhibit distinctive cathodoluminescence spectra. To a broader extent, these findings open the way to the ultimate fabrication of well-organized heterostructures made from ZnO nanowires, which can act as building blocks in a large number of electronic, optoelectronic, and photovoltaic devices.
Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines (2013)

Taken together, our results suggest that MitoQ may have potential as a novel therapeutic agent for the treatment of acute phases of inflammatory bowel disease.
DNA synthesized in the hepatitis B Dane particle DNA polymerase reaction (1977)

Radioactive DNA was prepared in extensive (4 h) Dane particle DNA polymerase reactions. In different experiments the amount of new DNA, determined by the amount of nucleotide incorporation into an acid-insoluble form, was between 29 and 45% of the total circular DNA isolated from Dane particle preparations after the reaction. DNA reassociation kinetics were used to determine the complexity of the newly synthesized DNA. In different experiments COt1/2 values, corresponding to between 625 and 1,250 nucleotide pairs, were obtained for the radioactive Dane particle DNA. These results suggest that a unique region (or regions), corresponsing to approximately one-fourth to one-half of the circular Dane particle DNA template, was copied one time during the reaction. DNA and RNA extracted from hepatitis B virus-infected liver but not from uninfected liver accelerated the rate of reassociation of radioactive DNA from Dane particles. These Dane particle DNA base sequences were found in alkali-stable, rapidly sedimenting DNA from infected liver as well as in DNA sedimenting at a rate similar to the DNA extracted from Dane particles. These findings are consistent with Dane particle DNA being hepatitis B virus DNA that is integrated into high-molecular-weight cellular DNA and transcribed into RNA in infected liver.