gebhart/patrepeval huggingface dataset:
<i>Staphylococcus aureus</i>Growth Boundaries: Moving towards Mechanistic Predictive Models Based on Solute-Specific Effects (2002)

The formulation of shelf-stable intermediate-moisture products is a critical food safety issue. Therefore, knowing the precise boundary for the growth-no-growth interface of Staphylococcus aureus is necessary for food safety risk assessment. This study was designed to examine the effects of various humectants and to produce growth boundary models as tools for risk assessment. The molecular mobility and the effects of various physical properties of humectants, such as their glass transition temperatures, their membrane permeability, and their ionic and nonionic properties, on S. aureus growth were investigated. The effects of relative humidity (RH; 84 to 95%, adjusted by sucrose plus fructose, glycerol, or NaCl), initial pH (4.5 to 7.0, adjusted by HCl), and potassium sorbate concentration (0 or 1,000 ppm) on the growth of S. aureus were determined. Growth was monitored by turbidity over a 24-week period. Toxin production was determined by enterotoxin assay. The 1,792 data points generated were analyzed by LIFEREG procedures (SAS Institute, Inc., Cary, N.C.), which showed that all parameters studied significantly affected the growth responses of S. aureus. Differences were observed in the growth-no-growth boundary when different humectants were used to achieve the desired RH values in both the absence and the presence of potassium sorbate. Sucrose plus fructose was most inhibitory at neutral pH values, while NaCl was most inhibitory at low pH values. The addition of potassium sorbate greatly increased the no-growth regions, particularly when pH was <6.0. Published kinetic growth and survival models were compared with boundary models developed in this work. The effects of solutes and differences in modeling approaches are discussed.
Ensuring consistency of feature-based decisions with a business rule system (2013)

Feature Models are widely used in some domains to represent variabilities and support decisions that configure a specific combination of domain elements. A feature configuration is created by selecting a features set that satisfies constraints imposed by the model. However, especially regarding complex or large models, end users are prone to making inconsistent decisions. In these cases, an automated support to assist users while resolving decision conflicts and restoring the configuration's validity is highly desirable. Thus, this paper proposes a flexible approach to ensure the consistency of feature configurations which is based on a Business Rules Management System (BRMS). Such systems are essential components in the world of business decision support applications due to facilities provided for constraints specification and execution management. The proposed approach shows how existing BRMS can be effectively used in a feature configuration process to resolve decision conflicts and restore the configuration correctness after user's illegal decisions while helping him/her to reason about possibilities that the model offers and to understand the impact of each decision-making. The main advantage of using a BRMS to specify and manage feature model constraints is the facility with which such complex activities can be supported. This paper reports preliminary research results achieved with the proposed approach.
SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of <i>Toxoplasma gondii</i> CDPK1 (2015)

We previously discovered compounds based on a 5-aminopyrazole-4-carboxamide scaffold to be potent and selective inhibitors of CDPK1 from <i>T. gondii</i>. The current work, through structure-activity relationship studies, led to the discovery of compounds (<b>34</b> and <b>35</b>) with improved characteristics over the starting inhibitor <b>1</b> in terms of solubility, plasma exposure after oral administration in mice, or efficacy on parasite growth inhibition. Compounds <b>34</b> and <b>35</b> were further demonstrated to be more effective than <b>1</b> in a mouse infection model and markedly reduced the amount of <i>T. gondii</i> in the brain, spleen, and peritoneal fluid, and <b>35</b> given at 20 mg/kg eliminated <i>T. gondii</i> from the peritoneal fluid.
Projektmanagement (1995)

Projekte unterscheiden sich von anderen Arbeiten und Routineaufgaben. Sie sind
Predicting early risk of chronic kidney disease in cats using routine clinical laboratory tests and machine learning (2019)

The use of models based on machine learning can support veterinary decision making by improving early identification of CKD.
Miniaturization of the Biconical Antenna for Ultrawideband Applications (2009)

A miniaturized, ultrawideband antenna for the 3.1 to 10.6 GHz frequency band is presented. The antenna is designed to have a low profile to enhance integration onto existing structures and a low directivity pattern for body worn applications. A systematic process to miniaturize the well-known biconical antenna is illustrated by adding several different geometric features that reduce the size of the antenna. After miniaturization, the vertical height of the antenna was reduced by over 60% while maintaining electrical performance. Prototype antennas were manufactured using low cost plastic injection molding and dipping processes to facilitate transition to mass production and to enhance the durability of the antenna. The simulated and measured reflection coefficient of the antenna show good agreement. Measured antenna gain patterns verify that the manufacturing process employed is capable of producing low loss antenna structures. Lastly, time domain short pulse measurements of the antenna verify that it does not appreciably distort radiated signals in the azimuthal plane.
Identification of novel light-induced genes in the suprachiasmatic nucleus (2007)

The photic signalling cascade in the suprachiasmatic nucleus activates an array of immediate-early genes, most of which have unknown functions in the circadian clock. Detected evolutionary conservation of CRE and TATA box elements in promoters of light-induced genes suggest that the functional role of these elements has likely remained the same over evolutionary time across mammalian orders.
Oxygen Reduction on Platinum Low-Index Single-Crystal Surfaces in Alkaline Solution:  Rotating Ring Disk<sub>Pt(</sub> <i> <sub>hkl</sub> </i> <sub>)</sub> Studies (1996)

The first results of a study of the oxygen reduction reaction on a rotating ring−disk electrode using single-crystal Pt disk electrodes in alkaline solution are presented. The order of activity of Pt(hkl) in 0.1M KOH increased in the sequence (100) < (110) < (111) for both oxygen and peroxide reduction. These differences are attributed to the structure sensitivity of hydroxyl anion (OH-) adsorption on Pt(hkl) and its inhibiting (site blocking) effect on oxygen kinetics. Two different types of OHads occur on Pt(100) and Pt(110), a reversible OHrv, and an irreversible OHir, while only the reversible form is formed on Pt(111). Very small fluxes (I R/N ≪ 0.01I D) of peroxide were detected at the ring at potentials where the surfaces have only the reversible form of OHads. More peroxide (I R/N < 0.03I D) was found with the Pt(100) and Pt(110)surfaces in the potential region where irreversible adsorption occurs. The mechanism of O2 reduction was also affected by adsorbed hydrogen with increased formation of peroxide ions in this potential region; correspondingly, adsorbed hydrogen was found to have an inhibiting effect on peroxide reduction, the effect decreasing in the order (111) > (100) ≫ (110).
Cytotoxic Diterpenoids from<i>Isodon enanderianus</i> (2003)

Five new ent-kaurane diterpenoids, enanderianins K-O (1-5), and one new ent-abietane diterpenoid, enanderianin P (6), together with five known ent-kaurane diterpenoids, rabdocoetsin A (7), rabdocoetsin B (8), rabdocoetsin D (9), megathyrin A (10), megathyrin B (11) were isolated from the aerial parts of Isodon enanderianus. Their structures were determined by spectral means. Some diterpenoids were tested for their cytotoxicity against the human tumor K562 cells. Compounds 1, 2, 6, 8, 9 showed significant inhibitory activities against K562 cells with IC50 values ranging from 0.13 to 0.87 microg/mL.
Sorceress (1991)

Article Free Access Share on Sorceress: a database approach to software configuration management Author: Chris Sheedy Software Engineering Technology Department, Tandem Computers Inc., 10555 Ridgeview Court, Cupertino, CA Software Engineering Technology Department, Tandem Computers Inc., 10555 Ridgeview Court, Cupertino, CAView Profile Authors Info & Claims SCM '91: Proceedings of the 3rd international workshop on Software configuration managementMay 1991 Pages 121–126https://doi.org/10.1145/111062.111078Published:01 May 1991Publication History 1citation318DownloadsMetricsTotal Citations1Total Downloads318Last 12 Months5Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Vision-based control of a quadrotor for perching on lines (2014)

We formulate the position-based visual servoing problem for a quadrotor equipped with a monocular camera and an IMU relying only on features on planes and lines in order to fly above and perch on arbitrarily oriented lines. We show that we are able to compute the orientation of an arbitrarily oriented line, the speed of the robot and its position with respect to the target line using two points at a known distance on the line. The direction of the velocity is derived from optical flow induced by features on a plane in the background Finally, we demonstrate fully autonomous flight and perching using a small 230 gram quadrotor with all the computations running on the robot.
Bismuth dimercaptopropanol (BisBAL) inhibits the expression of extracellular polysaccharides and proteins by <i>Brevundimonas diminuta</i>: Implications for membrane microfiltration (2007)

A 2:1 molar ratio preparation of bismuth with a lipophilic dithiol (3-dimercapto-1-propanol, BAL) significantly reduced extracellular polymeric substances (EPS) expression by Brevundimonas diminuta in suspended cultures at levels just below the minimum inhibitory concentration (MIC). Total polysaccharides and proteins secreted by B. diminuta decreased by approximately 95% over a 5-day period when exposed to the bismuth-BAL chelate (BisBAL) at near MIC (12 microM). Fourier-transform infrared spectroscopy (FTIR) suggested that a possible mechanism of biofilm disruption by BisBAL is the inhibition of carbohydrate O-acetylation. FTIR also revealed extensive homology between EPS samples with and without BisBAL treatment, with proteins, polysaccharides, and peptides varying predominantly only in the amount expressed. EPS secretion decreased following BisBAL treatment as verified by atomic force microscopy and scanning electron microscopy. Without BisBAL treatment, a slime-like EPS matrix secreted by B. diminuta resulted in biofouling and inefficient hydrodynamic backwashing of microfiltration membranes.
Colour histogram analysis for melanoma discrimination in clinical images (2003)

The results presented in this work suggest that lesion colour in clinical images is strongly related to the presence of melanoma in that lesion. However, colour information should be combined with other information in order to further reduce the false negative and false positive rates.
Microwave irradiation in solvent-free conditions: an eco-friendly methodology to prepare indazoles, pyrazolopyridines and bipyrazoles by cycloaddition reactions (2000)

A study on the behaviour of vinylpyrazoles, pyrazolyl imines and pyrazolyl hydrazones as dienes or dipoles is reported. Cycloaddition of the aforementioned compounds with electron-poor reagents under microwave irradiation in solvent-free conditions permits the preparation of indazoles, pyrazolopyridines and bipyrazoles in moderate to good yields. This represents an eco-friendly, green approach to these valuable pyrazole derivatives that avoids the harsh or highly contaminant conditions involving classical heating and offers a reduction or even elimination of solvent use and recovery, simplification of the work up procedures, facility of scale up and savings in energy consumption, in addition with higher yields.
Transient transmural reduction of myocardial blood flow demonstrated by thallium-201 scintigraphy, as a cause of variant angina. (1976)

In previous studies we demonstrated that variant angina could not be attributed to increased myocardial demands. In order to investigate whether a reduction of regional myocardial blood supply could be responsible for these ischemic episodes, we studied regional myocardial perfusion in six patients admitted to our coronary care unit. Myocardial scintigrams, obtained 5-7 min following i.v. injection of 1 mCi of thallium-201, performed during an episode of ST-segment elevation, showed transmural deficits of tracer uptake in the heart wall corresponding to the leads showing ST-segment elevation. These regional deficits ahd disappeared by 2 hours because of late uptake in previously ischemic myocardium. One week later, following injections performed in the absence of acute ischemia, no deficit was apparent. Tracer uptake in ischemic areas was 60% to 85% of that observed a week later. After adjusting for thallium-201 kinetics and counting geometry promblems., these scintigrams actually represent large underestimations of actual flow reduction. Thus variant angina appears to be caused by massive transmural reduction of myocardial blood supply.
Plasma deposition of fluorocarbon thin films from c-C4F8 using pulsed and continuous rf excitation (2005)

Fluorocarbon films of varying composition have been deposited from pulsed and continuous plasmas of octafluorocyclobutane (c-C4F8) and c-C4F8/Ar. Continuous plasma deposition rates are a very weak function of applied rf power (may be within experimental error). Pulsed plasma deposition rates are significantly lower than continuous plasma rates at the same average power. The pulsed plasma deposition rates can be attributed almost entirely to the plasma on time during the pulse, but there is a slight dependence on pulse off time. Ar addition affects the deposition rates through a residence time effect, but also affects the deposition chemistry by reducing the degree of C4F8 dissociation, resulting in more fluorinated films. Refractive indices for all films increase approximately linearly with applied rf power, with the pulsed plasma-deposited films falling on the same curve. Carbon 1s x-ray photoelectron spectroscopy shows that the continuous plasma-deposited films become increasingly fluorinated as the rf power is decreased. Pulsed plasma films are more fluorinated than similar average power continuous plasma films: 44% CF2 for 10/50 (400 W on time, 67 W average power) versus 37% for 50 W continuous. Literature and preliminary gas-phase measurements suggest that the C4F8 is not fully dissociated in either plasma system and that larger species in the gas phase may play a significant role in the deposition mechanisms.
Vaccination against<i>Chlamydia</i>Genital Infection Utilizing the Murine<i>C. muridarum</i>Model (2010)

Chlamydia trachomatis genital infection is a worldwide public health problem, and considerable effort has been expended on developing an efficacious vaccine. The murine model of C. muridarum genital infection has been extremely useful for identification of protective immune responses and in vaccine development. Although a number of immunogenic antigens have been assessed for their ability to induce protection, the majority of studies have utilized the whole organism, the major outer membrane protein (MOMP), or the chlamydial protease-like activity factor (CPAF). These antigens, alone and in combination with a variety of immunostimulatory adjuvants, have induced various levels of protection against infectious challenge, ranging from minimal to nearly sterilizing immunity. Understanding of the mechanisms of natural infection-based immunity and advances in adjuvant biology have resulted in studies that are increasingly successful, but a vaccine licensed for use in humans has not yet been brought to fruition. Here we review immunity to chlamydial genital infection and vaccine development using the C. muridarum model.
A novel band-to-band tunneling induced convergence mechanism for low current, high density flash EEPROM applications (2002)

A new low current two-step erasing scheme for "repairing" over-erased flash EEPROM cells has been developed. The cell convergence is achieved with 10 V on the control gate and 5 V on the source and drain for 50 ms. The convergence current is kept to below 1 nA per cell. A substrate BTBT tunneling induced hot electron injection mechanism is proposed for convergence. No significant oxide degradation is seen in the method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Parathyroid Hormone Protects against Periodontitis-associated Bone Loss (2003)

Parathyroid hormone (PTH) functions as a major mediator of bone remodeling and as an essential regulator of calcium homeostasis. In addition to the well-established catabolic effects (activation of bone resorption) of PTH, it is now recognized that intermittent PTH administration has anabolic effects (promotion of bone formation). The aim of this study was to investigate whether intermittent administration of PTH in rodents would block the alveolar bone loss observed in rats when a ligature model of periodontitis is used. Morphometric analysis showed that intermittent PTH administration (40 microg/kg) was able to protect the tooth site from periodontitis-induced bone resorption. In addition, there was a significant reduction in the number of inflammatory cells at the marginal gingival area in sections obtained from animals receiving PTH compared with control animals. These findings demonstrated that intermittent PTH administration was able to protect against periodontitis-associated bone loss in a rodent model.
Atom probe analysis and field emission studies of silicon (1994)

Single ungridded silicon tips have been studied by field emission current–voltage characterization, field emission imaging, field ion imaging, and pulsed laser atom probe (PLAP) analysis. Changes in field emission characteristics were observed as a thin contaminant layer (oxygen, hydrogen, carbon, and carbon monoxide) formed on the surface of clean field evaporated silicon tips. Removal of the contaminant layer by pulsed laser-assisted field desorption restored the original field emission characteristics. Clean silicon tips that were oxidized in air began to emit at half the voltage required for unoxidized tips. As the voltage was increased, a sudden irreversible increase in field emission current was observed. PLAP analysis and field emission imaging showed that this effect was caused by the disruption of the oxide layer shortly after the onset of field emission. After the oxide disruption, field emission occurred from regions of sharp local geometry around the circumference of the tip. Removal of these regions by field evaporation or PLAP produced field emission characteristics very similar to those obtained from clean silicon tips. This explains a long-standing problem in understanding the ‘‘switch-on’’ behavior of silicon emitters.
The Drift of the Xsens Moven Motion Capturing Suit during Common Movements in a Working Environment (2009)

When using inertial motion capturing technology, the accuracy of the results is strongly influenced by the socalled drift. This paper describes the drift of an Xsens Moven motion capturing suit during common movements, measured in a standard working environment. The test is performed in a room not shielded from magnetic disturbances, to acquire insight on how accurate the absolute position determination of the motion capturing system is during use in a standard environment. The test is performed by walking a path with the same start and end point, and reviewing the measured difference in the absolute position of one sensor.
Radio-frequency enhanced decontamination of soils contaminated with halogenated hydrocarbons (1989)

There has been considerable effort in the development of innovative treatment technologies for the cleanup of sites containing hazardous wastes such as hydrocarbons and chlorinated hydrocarbons. Typical examples of such waste material are: chlorinated solvents, polychlorinated biphenyls, waste aviation fuels, gasoline, etc. The feasibility of treating waste sites containing such materials by in-situ radio frequency heating was established by the study through bench- and pilot-scale experiments. A design for an in-situ field test was developed for the treatment of sites containing solvents and aviation fuel. Cost studies were performed to estimate the treatment cost of a system for the decontamination of sites containing fuels, etc.
Soil Water Evaporation: Surface Residue Rate and Placement Effects (1969)

Abstract Evaporation with time was measured from columns of originally wetted fine sandy loam soil subjected to uniform daily evaporative potential and treated with various rates of surface residue. During the initial constant rate drying stage, evaporation decreased with increasing residue rates. Conjunctively, the period of constant rate drying was appreciably lengthened with decreasing evaporation rates. After prolonged falling rate drying, cumulative evaporative losses were nearly equal irrespective of surface residue. It was hypothesized that during falling rate drying and with limited quantities of residue, total evaporation might be less if the residue were placed on less than the entire soil surface in concentrated zones. Utilizing the available data, calculated curves were constructed which supported the hypothesis.
Fed batch enzymatic saccharification of food waste improves the sugar concentration in the hydrolysates and eventually the ethanol fermentation by Saccharomyces cerevisiae H058 (2012)

The enzymatic hydrolysis of food waste by commercially available enzymes and the subsequent ethanol fermentation of the hydrolysates by Saccharomyces cerecisiae H058 were studied in this work. The optimum batch enzymatic conditions were found to be saccharification pH of 4.5, temperature of 55!, glucoamylase concentration of 120 u/g, α-amylase concentration of 10 u/g, solid-liquid ratio of 1: 0.75 (w/w). Fed batch hydrolysis process was started with a solid-liquid ratio of 1: 1 (w/w), with solid food waste added at time lapse of 2 h to get a final solid-liquid ratio of 1: 0.5 (w/w). After 4 h of reaction, the reducing sugar concentration reached 194.43 g/L with a enzymatic digestibility of 93.12%. Further fermentation of the batch and fed batch enzymatic hydrolysates, which contained reducing sugar concentration of 131.41 and 194.43 g/L respectively, was performed using Saccharomyces cerevisiae H058, 62.93 and 90.72 g/L ethanol was obtained within 48 h.