gebhart/patrepeval huggingface dataset:
Modification of the glyoxalase system in clinical diabetes mellitus (1993)

Conference Article| May 01 1993 Modification of the glyoxalase system in clinical diabetes mellitus ANTONY C. McLELLAN; ANTONY C. McLELLAN 1Department of Chemistry and Biological Chemistry, University of Essex, Wivenhoe Park, Colchester, Essex C04 3SQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar PAUL J. THORNALLEY; PAUL J. THORNALLEY 1Department of Chemistry and Biological Chemistry, University of Essex, Wivenhoe Park, Colchester, Essex C04 3SQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar JONATHAN BENN; JONATHAN BENN *UMDS, St Thomas's Hospital, Lambeth Palace Road, London SE1 7EH, U.K. Search for other works by this author on: This Site PubMed Google Scholar PETER H. SONKSEN PETER H. SONKSEN *UMDS, St Thomas's Hospital, Lambeth Palace Road, London SE1 7EH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1993) 21 (2): 158S. https://doi.org/10.1042/bst021158s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation ANTONY C. McLELLAN, PAUL J. THORNALLEY, JONATHAN BENN, PETER H. SONKSEN; Modification of the glyoxalase system in clinical diabetes mellitus. Biochem Soc Trans 1 May 1993; 21 (2): 158S. doi: https://doi.org/10.1042/bst021158s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1993 Biochemical Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
Computer vision system for in-house video surveillance (2005)

In-house video surveillance to control the safety of people living in domestic environments is considered. In this context, common problems and general purpose computer vision techniques are discussed and implemented in an integrated solution comprising a robust moving object detection module which is able to disregard shadows, a tracking module designed to handle large occlusions, and a posture detector. These factors, shadows, large occlusions and people's posture, are the key problems that are encountered with in-house surveillance systems. A distributed system with cameras installed in each room of a house can be used to provide full coverage of people's movements. Tracking is based on a probabilistic approach in which the appearance and probability of occlusions are computed for the current camera and warped in the next camera's view by positioning the cameras to disambiguate the occlusions. The application context is the emerging area of domotics (from the Latin word domus, meaning ‘home’, and informatics). In particular, indoor video surveillance, which makes it possible for elderly and disabled people to live with a sufficient degree of autonomy, via interaction with this new technology, which can be distributed in a house at affordable costs and with high reliability.
Full-bridge capacitive extensometer (1993)

Capacitive transducers have proven to be very effective sensors of small displacements, because of inherent stability and noninvasive high resolution. The most versatile ones have been those of a differential type, in which two elements are altered in opposite directions in response to change of the system parameter being monitored. Oftentimes, this differential pair has been incorporated into a bridge circuit, which is a useful means for employing synchronous detection to improve signal to noise ratios. Unlike previous differential capacitive dilatometers which used only two active capacitors, the present sensor is a full-bridge type, which is well suited to measuring low-level thermal expansions. This analog sensor is capable of 0.1 μm resolution anywhere within a range of several centimeters, with a linearity of 0.1%. Its user friendly output can be put on a strip chart recorder or directed to a computer for sophisticated data analysis.
Carcinoembryonic antigen: an invaluable marker for advanced breast cancer. (1998)

Serial serum Carcinoembryonic antigen (CEA) levels were measured in 150 individuals (50 patients with breast cancer, 50 benign breast diseases and 50 other controls). These levels were correlated with clinicopathological parameters and follow-up information. Serum CEA levels were independent of the primary tumor status, their histology, lymphoreticular response and the patients' characteristics as well as the age, sex and the menstrual status. However, the nodal status, number of involved nodes and the grade of the tumors had significant influence on the level of serum CEA. Breast cancer patients especially those with metastasis had significantly higher serum CEA levels as compared to the controls and those with localised disease, irrespective of the site of metastasis. These levels were lowered appreciably by the disease regression and were raised or stable during the disease progression. Receiver operating characteristic (ROC) curve showed metastasis to be more frequent in patients with pretreatment serum CEA levels above 25 ng/ml and persistent post treatment CEA levels above 15 ng/ml. Serum CEA level was found to be a valuable prognostic indicator for advanced breast cancer and serial serum CEA levels provided an average lead time of about 3.9 months before the clinical appearance of metastasis.
A Novel Three Serum Phospholipid Panel Differentiates Normal Individuals from Those with Prostate Cancer (2014)

In summary, we have demonstrated that ePC 38:5, PC 40:3, and PC 42:4 may serve as early predictive serum markers for the presence of PCa.
Last Level Cache (LLC) Performance of Data Mining Workloads On a CMP - A Case Study of Parallel Bioinformatics Workloads (2006)

With the continuing growth in the amount of genetic data, members of the bioinformatics community are developing a variety of data-mining applications to understand the data and discover meaningful information. These applications are important in defining the design and performance decisions of future high performance microprocessors. This paper presents a detailed data-sharing analysis and chip-multiprocessor (CMP) cache study of several multithreaded data-mining bioinformatics workloads. For a CMP with a three-level cache hierarchy, we model the last-level of the cache hierarchy as either multiple private caches or a single cache shared amongst different cores of the CMP. Our experiments show that the bioinformatics workloads exhibit significant data-sharing - 50-95% of the data cache is shared by the different threads of the workload. Furthermore, regardless of the amount of data cache shared, for some workloads, as many as 98% of the accesses to the last-level cache are to shared data cache lines. Additionally, the amount of data-sharing exhibited by the workloads is a function of the total cache size available - the larger the data cache the better the sharing behavior. Thus, partitioning the available last-level cache silicon area into multiple private caches can cause applications to lose their inherent data-sharing behavior. For the workloads in this study, a shared 32 MB last-level cache is able to capture a tremendous amount of data-sharing and outperform a 32 MB private cache configuration by several orders of magnitude. Specifically, with shared last-level caches, the bandwidth demands beyond the last-level cache can be reduced by factors of 3-625 when compared to private last-level caches.
Engineering design using genetic algorithms (2007)

As modern computational and modeling technologies grow, engineering design heavily relies on computer modeling and simulation to accelerate design cycles and save cost. A complex design problem will involve many design parameters and tables. Exploring design space and finding optimal solutions are still major challenges for complex systems. This dissertation proposed to use Genetic Algorithms to optimize engineering design problems. It proposed a software infrastructure to combine engineering modeling with Genetic algorithms and covered several aspects in engineering design problems. The dissertation suggested a new Genetic Algorithm (Completely dominant Genetic algorithm) to quickly identify High Performance Areas for Engineering Design. To help design engineers to explore design space, the dissertation used a new visualization tool to demonstrate high dimensional Genetic Algorithm results in dynamical graphics. Robustness of design is critical for some of the engineering design applications due to perturbation and manufacturing tolerance. This dissertation demonstrated to use Genetic Algorithms to locate robust design areas and provided a thorough discussion on robustness and diversity in depth.
Theoretical-slope method of end point detection (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheoretical-slope method of end point detectionJ. R. Dean and W. E. HarrisCite this: Anal. Chem. 1968, 40, 8, 1213–1216Publication Date (Print):July 1, 1968Publication History Published online1 May 2002Published inissue 1 July 1968https://pubs.acs.org/doi/10.1021/ac60264a018https://doi.org/10.1021/ac60264a018research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Preparation and characterization of selectively isotopically labeled nylon 66 polymers (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and characterization of selectively isotopically labeled nylon 66 polymersR. J. Angelo, H. Miura, K. H. Gardner, D. B. Chase, and A. D. EnglishCite this: Macromolecules 1989, 22, 1, 117–121Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ma00191a023https://doi.org/10.1021/ma00191a023research-articleACS PublicationsRequest reuse permissionsArticle Views545Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Laminins 2 and 4 are expressed by human decidual cells. (1996)

During pregnancy, the resident stromal cells of the endometrium differentiate to become decidual cells and produce a pericellular basement membrane. We used immunofluorescence and Western blotting with a panel of monoclonal Ab specific for various laminin subunits to examine the composition of decidual laminin. The stromal cell basement membrane contained subunits alpha 2 (M), beta 1 (B1), beta 2 (S), and gamma 1 (B2). Low levels of alpha 1 could also be detected. The glandular and vascular basement membranes of decidual tissue contained subunits alpha 1 (A), beta 1, and gamma 1. An extract was produced from decidual extracellular matrix. Western blots of nonreducing gels showed the presence of high molecular weight complexes containing alpha 2, beta 1, beta 2, and gamma 1. These data indicated that laminins 2 and 4 are coexpressed by decidual cells. Laminin 1 was present in the extract as a minor component. In contrast, cultured stromal cells expressed laminin 1 as the major secreted variant. Immunolocalization was carried out using tissue from various stages of the nonpregnant cycle. The alpha 2 chain polypeptide was absent in the proliferative phase of the cycle but present in late secretory phase in perivascular areas where predecidual differentiation occurs. Reverse transcriptase-PCR experiments confirmed the presence of alpha 2 chain mRNA in decidua but showed that this transcript is detectable throughout the nonpregnant cycle. The results showed that laminins 2 and 4 are hormonally regulated products of decidual cells. The composition of the vascular and epithelial basement membranes remained constant throughout the cycle.
Human DMBT1-Derived Cell-Penetrating Peptides for Intracellular siRNA Delivery (2017)

Small interfering RNA (siRNA) is a promising molecule for gene therapy, but its therapeutic administration remains problematic. Among the recently proposed vectors, cell-penetrating peptides show great promise in in vivo trials for siRNA delivery. Human protein DMBT1 (deleted in malignant brain tumor 1) is a pattern recognition molecule that interacts with polyanions and recognizes and aggregates bacteria. Taking advantage of these properties, we investigated whether specific synthetic DMBT1-derived peptides could be used to formulate nanoparticles for siRNA administration. Using an electrophoretic mobility shift assay and UV spectra, we identified two DMBT1 peptides that could encapsulate the siRNA with a self- and co-assembly mechanism. The complexes were stable for at least 2 hr in the presence of either fetal bovine serum (FBS) or RNase A, with peptide-dependent time span protection. ζ-potential, circular dichroism, dynamic light scattering, and transmission electron microscopy revealed negatively charged nanoparticles with an average diameter of 10-800 nm, depending on the reaction conditions, and a spherical or rice-shaped morphology, depending on the peptide and β-helix conformation. We successfully transfected human MCF7 cells with fluorescein isothiocyanate (FITC)-DMBT1-peptide-Cy3-siRNA complexes. Finally, DMBT1 peptides encapsulating an siRNA targeting a fluorescent reporter gene showed efficient gene silencing in MCF7-recombinant cells. These results lay the foundation for a new research line to exploit DMBT1-peptide nanocomplexes for therapeutic siRNA delivery.
Absence of Sensory Neurons before Target Innervation in Brain-Derived Neurotrophic Factor-, Neurotrophin 3-, and TrkC-Deficient Embryonic Mice (1997)

Gene-targeting experiments of Trk receptors and neurotrophins has confirmed the expectation that embryonic sensory and sympathetic neurons require neurotrophin function for survival. They have further revealed correlation between a specific neurotrophin requirement and eventual sensory modality. We have analyzed embryonic and neonatal mice with mutations in the BDNF, neurotrophin 3 (NT-3), and TrkC genes. Our data confirm an unexpectedly high proportion of sensory neuron losses in NT-3 (>70%), BDNF (>20%), and TrkC (>30%) mutants, which encompass populations thought to be NGF-dependent. Direct comparison of TrkC and NT-3 mutants indicates that only a subset of the NT-3-dependent neurons also requires TrkC. The observed losses in our TrkC mutant, which is null for all proteins encoded by the gene, are more severe than those previously reported for the kinase-negative TrkC mutation, implicating additional and important functions for the truncated receptors. Our data further indicate that mature NGF-requiring neurons undergo precocious and transitory requirements for NT-3 and/or BDNF. We suggest that neurotrophins may function in creating early heterogeneity that would enable ganglia to compensate for diverse modality requirements before the period of naturally occurring death.
ChemInform Abstract: STUDIES ON ORGANOPHOSPHORUS COMPOUNDS. XVI. ON O,O‐DIALKYL DITHIOPHOSPHORIC ACIDS AND N,N,N′,N′‐TETRAMETHYLTHIOPHOSPHORIC DIAMIDE AS THIATION AGENTS‐ CONVERSION OF CARBOXAMIDES INTO THIOCARBOXAMIDES, ALKYL DITHIOCARBOXYLATES, OR NITRILES (1977)

Abstract Die Amide (I) werden durch Erhitzen in der Dithiophosphorsäure (II) in die Thioamide (III) umgewandelt, wobei mit zunehmender Temperatur und Reaktionszeit zunehmend auch die Dithioester (IV) gebildet werden.
Densities and expansion coefficients of nafion polymers (1979)

The densities and expansion coefficients of several Nafions in the acid and salt form were measured. For some samples, effects of variations in the equivalent weight, moisture content, and degree of uniaxial orientation were explored. The densities, which show considerable experimental scatter, seem to be independent of the equivalent weight but to be a strong function of the moisture content. Thin films of the as-received, unbacked polymer are strongly uniaxially oriented. After annealing, reproducible values of the expansion coefficient can be obtained. Two distinct breaks in the linear expansion curve are seen; in the salts, the upper one correlates with the glass transition of the material, while the lower one is found in the vicinity of the mechanical β-dispersion of the polymer. The large scatter of the experimental densities is consistent with the hypothesis that the sample is subject either to a microphase separation process which is strongly influenced by the sample history and which affects the density of the material very strongly, or to partial crystallization of the polymer, or both.
FollowMe: Person following and gesture recognition with a quadrocopter (2013)

In this paper, we present an approach that allows a quadrocopter to follow a person and to recognize simple gestures using an onboard depth camera. This enables novel applications such as hands-free filming and picture taking. The problem of tracking a person with an onboard camera however is highly challenging due to the self-motion of the platform. To overcome this problem, we stabilize the depth image by warping it to a virtual-static camera, using the estimated pose of the quadrocopter obtained from vision and inertial sensors using an Extended Kalman filter. We show that such a stabilized depth video is well suited to use with existing person trackers such as the OpenNI tracker. Using this approach, the quadrocopter not only obtains the position and orientation of the tracked person, but also the full body pose - which can then for example be used to recognize hand gestures to control the quadrocopter's behaviour. We implemented a small set of example commands (“follow me”, “take picture”, “land”), and generate corresponding motion commands. We demonstrate the practical performance of our approach in an extensive set of experiments with a quadrocopter. Although our current system is limited to indoor environments and small motions due to the restrictions of the used depth sensor, it indicates that there is large potential for such applications in the near future.
Go wild with food! (2012)

There are lots of edible plants growing wild in Britain. Take a basket and go on a culinary adventure, foraging for food that is both nutritious and free!
Convenient syntheses of cyclic carboxamides from .ALPHA.,.BETA.,.GAMMA.,.DELTA. and .EPSILON.-halocarboxamides under phase transfer conditions. (1982)

Piperazine-2, 5-diones (2) were prepared by N-alkylation between two molecules of α-halocarboxamides (1) in the presence of a phase transfer catalyst in yields of 64-88%. β, γ, δ and ε-Lactams (6, 9 and 13) were similarly synthesized by intramolecular N-alkylation of the corresponding halocarboxamides (5, 8 and 12) under phase transfer conditions in 53-99% yields.
Behavioral conditioning of immunosuppression is possible in humans (2002)

Behavioral conditioned immunosuppression has been described in rodents as the most impressive demonstration of brain-to-immune system interaction. To analyze whether behavioral conditioned immunosuppression is possible in humans, healthy subjects in this double-blind, placebo-controlled study were conditioned in four sessions over 3 consecutive days, receiving the immunosuppressive drug cyclosporin A as an unconditioned stimulus paired with a distinctively flavored drink (conditioned stimulus) each 12 h. In the next week, re-exposure to the conditioned stimulus (drink), but now paired with placebo capsules, induced a suppression of immune functions as analyzed by the IL-2 and IFN-gamma mRNA expression, intracellular production, and in vitro release of IL-2 and IFN-gamma, as well as lymphocyte proliferation. These data demonstrate for the first time that immunosuppression can be behaviorally conditioned in humans.
Photodegradation of Oligomeric Polyesters Containing Anthraquinone and 1,2-Diamine Units. Single Electron Transfer Induced Cation Radical Bond Cleavage in the Solid State (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotodegradation of Oligomeric Polyesters Containing Anthraquinone and 1,2-Diamine Units. Single Electron Transfer Induced Cation Radical Bond Cleavage in the Solid StateJeffrey W. Leon and David G. WhittenCite this: J. Am. Chem. Soc. 1995, 117, 8, 2226–2235Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/ja00113a012https://doi.org/10.1021/ja00113a012research-articleACS PublicationsRequest reuse permissionsArticle Views207Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts