gebhart/patrepeval huggingface dataset:
Efficacy of chemotherapy in patients with recurrent pancreatic cancer. (2017)

466 Background: Gemcitabine (GEM) plus nab-paclitaxel (GnP) and FOLFIRINOX (FFX) are standard first-line chemotherapy regimens for metastatic pancreatic cancer (MPC) patients. GEM and S-1 are also used for these patients in Japan. However, the phase 3 trials included a small proportion of recurrent pancreatic cancer (RPC) patients, and patients who had received adjuvant chemotherapy were excluded. In clinical practice, RPC is treated in the same way as MPC. The aim of this study is to compare the efficacy of chemotherapy between RPC and MPC. Methods: We retrospectively analyzed the patients with RPC or MPC who received GnP, FFX, GEM, or S-1 as first-line chemotherapy between January 2014 and March 2016 in our institution. RPC was defined as pancreatic cancer with recurrence after R0 or R1 resection. Overall survival (OS), progression-free survival (PFS), response rate (RR), and disease control rate (DCR) were evaluated. Multivariate analyses of OS were performed with the use of a Cox proportional-hazard model. Results: A total of 181 patients, 40 RPC and 141 MPC, were selected in this study. RPC and MPC groups were similar with respect to age, sex, and performance status (PS). However, the RPC group had lower percentage of liver metastases (P < 0.001). The regimens were GnP/FFX/GEM/S-1: 10/3/20/7 in the RPC group and 37/34/67/3 in the MPC group, respectively. In the RPC group, 31 of 40 patients had received adjuvant chemotherapy; S-1/GEM: 24/7. The median OS was 16.6 months in the RPC group as compared with 9.7 months in the MPC group (hazard ratio [HR] 0.64, 95% confidence interval [CI] 0.37–1.10, P = 0.11). The median PFS was 4.8 months in the RPC group and 4.4 months in the MPC group (HR 0.86, 95% CI 0.57–1.30, P = 0.47). The RR was 10% versus 14% (P = 0.79), the DCR was 50% versus 52% (P = 0.86), in the two groups, respectively. Multivariate analysis showed PS (HR 2.19, 95% CI 1.38–3.49) and liver metastases (HR 2.34, 95% CI 1.47–2.34) were independent predictors of OS. On the other hand, RPC or MPC was not found to be an independent prognostic factor (HR 1.19, 95% CI 0.67–2.13). Conclusions: It is suggested that chemotherapy in RPC may have similar efficacy compared to MPC. The relatively longer OS in the RPC group seems to associate with the lower percentage of liver metastases.
Gas Solubilities in Aqueous Solutions of Organic Substances (1996)

The solubilities of He, N2, O2, CH4, and CO2 in aqueous solutions of glycerol, acetic acid, glucose, sucrose, and lactose were measured at 303.2 K. Additional data were generated for CO2 at 293.2 K and 323.2 K. The present results and literature data were analyzed to develop an empirical model. The parameter set allows predictions for 15 gases and 63 organic substances at temperatures between 273 K and 343 K.
An experimental 2-bit/cell storage DRAM for macrocell or memory-on-logic application (1989)

A multiple-level 2-bit/cell storage technique for DRAMs (dynamic random-access memories) has been developed. The total RAM area is reduced and the cell array is cut in half. Since the memory cell area is especially defect-sensitive, this technique is highly effective for process yield improvement. Reasonable access time has been realized with this technique: 170 ns is still fast enough for many ASIC (application-specific integrated circuit) memory applications. This technique meets the requirement of high density and moderate speed. It was found that the 2-bit/cell storage technique is suitable for macrocell or memory-on-logic type application.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Making nested rotations convenient for the user (1978)

Subimage motion in a three-dimensional computer graphic system is much easier for the user to control if the subimage moves the same direction as his hand while he manipulates the control device. The implementation of such coordinated motion of hand and subimage implies modification of the normal procedure for calculating transformations. The convenience of such manipulation also depends on appropriate selection or design of the input device.
The Effect of Platelet Rich Plasma from Bone Marrow Aspirate with Added Bone Morphogenetic Protein-2 on the Achilles Tendon-Bone Junction in Rabbits (2011)

Bone marrow derived PRP and BMP-2 in fibrin glue accelerated healing in a rabbit model of tendon-bone junction injury.
Area and time limitations of FPGA-based virtual hardware (2002)

This paper examines the limitations of integrating programmable logic with a powerful core processor on the same die. An abstract model to investigate the area and delay of field programmable gate array architectures is presented. The model is used to show that a system implemented on FPGAs will require as much as 100 times more die area than its custom VLSI implementation and would be about 10 times slower. Our analysis shows that this high cost, inherent to the current FPGA-based architectures, is a severe limitation to virtual hardware development. A new approach to cell architecture and array organization is needed to deliver high computational speed-ups comparable to multiple processor systems with the same total die area.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An efficient algorithm for heap storage allocation (1988)

article Free Access Share on An efficient algorithm for heap storage allocation Authors: C. B. Weinstock Carnegie-Mellon Univ. Pittsburgh, PA Carnegie-Mellon Univ. Pittsburgh, PAView Profile , W. A. Wulf Univ. of Virginia, Charlottesville Univ. of Virginia, CharlottesvilleView Profile Authors Info & Claims ACM SIGPLAN NoticesVolume 23Issue 10Oct. 1988 pp 141–148https://doi.org/10.1145/51607.51619Published:01 October 1988Publication History 32citation1,948DownloadsMetricsTotal Citations32Total Downloads1,948Last 12 Months242Last 6 weeks29 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
INTRASPECIFIC VARIATION IN STRESS‐INDUCED HYDROGEN PEROXIDE SCAVENGING BY THE ULVOID MACROALGA <i>ULVA LACTUCA</i><sup>1</sup> (2007)

We investigated the presence and kinetics of the oxidative stress response in intertidal and subtidal individuals of the ulvoid macroalga Ulva lactuca L. Stress responses, as measured with both enzymatic and fluorescent‐based antioxidant assays, differed between individuals collected from a subtidal and an intertidal habitat. Subtidal individuals secreted significantly more hydrogen peroxide (H 2 O 2 ) than intertidal individuals when subjected to osmotic stress or desiccation. The activity of reactive‐oxygen‐scavenging enzymes and the ability to scavenge exogenous H 2 O 2 were lower in subtidal than in intertidal individuals, suggesting that subtidal individuals are less stress tolerant. In vitro experimentation demonstrated that millimolar concentrations of dimethylsulfoniopropionate (DMSP) and its breakdown products could efficiently scavenge H 2 O 2 , with DMSP being a less‐effective scavenger than dimethyl sulfide (DMS), acrylic acid, and acrylate. The addition of H 2 O 2 at concentrations of 2.5 mM or greater induced the cleavage of DMSP into DMS and acrylic acid in subtidal individuals. Intertidal individuals were affected in the same manner with the addition of 5 mM H 2 O 2 . There were no differences in the amounts of DMSP cleavage in subtidal and intertidal algae when the algae were subjected to hyposaline conditions. Our data suggest that the oxidative‐stress‐induced cleavage of DMSP affords products with efficient H 2 O 2 ‐scavenging abilities. In addition, U. lactuca individuals growing in intertidal habitats are better acclimatized to changing environments and thus have a higher threshold for oxidative stress than conspecifics in subtidal habitats.
Mediastinoscope: another use. (1986)

We describe a technique for the retrieval of left atrial pressure monitoring catheters using a mediastinoscope. The procedure is simple, safe and it can be accomplished quickly without re-opening the sternum.
Partial biochemical characterization of IgG<sub>1</sub>‐inducing factor (1985)

IgG1 induction factor elevates the IgG1 and suppresses the IgG3 and IgG2b responses in lipopolysaccharide-stimulated murine spleen cell cultures. By the use of a quantitative assay, it was found that the three activities, induction of IgG1 and reduction of IgG3 and IgG2b synthesis, were found in the same fractions after different chromatographic procedures, suggesting that the same molecule was responsible for the effects. The factor was precipitated by 60-90% saturation of ammonium sulfate and was sensitive to proteolytic cleavage and to treatment with a buffer of pH 10. It had an apparent molecular mass of 20 kDa as judged by gel filtration chromatography and was separated into two peaks after isoelectric focusing, pI 7.4-7.2 and 6.4-6.2, respectively. Finally it was weakly hydrophobic and negatively charged at pH 7.55. These characteristics indicate that the factor is different from many previously characterized lymphokines and similar or identical to the B cell stimulating factor-1 (BSF-p1). The relevance of these findings to the mechanism of the immunoglobulin class switch is discussed.
The Boomerang White Paper: A Page as You Like It (1995)

Boomerang is a dynamic HTML page reconfiguration system. A user accesses Boomerang via the Common Gateway Interface. The user supplies a page name and a template, Boomerang fetches the requested page and uses the template to reconfigure it. The template is a sequence of string manipulation rules. The rules are written in a simple regular expression-based pattern matching language. Boomerang also parses HTML variables informs and query strings and makes those variables available in the template. By taking advantage of Boomerang's dynamic page reconfiguration features, users can easily add navigational links, suppress images, redefine HTML tags, and reshape a page as desired. Since Boomerang is reached through the Common Gateway Interface and understands HTML variables, Boomerang can also be used as a general form-handling script. Several examples are given to show the utility of Boomerang. Boomerang is compatible with existing browsers and servers and does not compromise their security.
Rearrangements of oxahomoadamantane derivatives in acidic media (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRearrangements of oxahomoadamantane derivatives in acidic mediaHelmut Duddeck, Volker Wiskamp, and Doris RosenbaumCite this: J. Org. Chem. 1981, 46, 26, 5332–5336Publication Date (Print):December 1, 1981Publication History Published online1 May 2002Published inissue 1 December 1981https://pubs.acs.org/doi/10.1021/jo00339a014https://doi.org/10.1021/jo00339a014research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modulation of Aflatoxin B1–Mediated Genotoxicity in Primary Cultures of Human Hepatocytes by Diindolylmethane, Curcumin, and Xanthohumols (2009)

This study employed cultured human primary hepatocytes to investigate the ability of the putative chemopreventive phytochemicals curcumin (CUR), 3,3'-diindolylmethane (DIM), isoxanthohumol (IXN), or 8-prenylnaringenin (8PN) to reduce DNA adduct formation of the hepatocarcinogen aflatoxin B1 (AFB). Following 48 h of pretreatment, DIM and 8PN significantly increased AFB-DNA adduct levels, whereas CUR and IXN had no effect. DIM greatly enhanced the transcriptional expression of cytochrome P450 (CYP) 1A1 and CYP1A2 mRNA. Glutathione S-transferase mRNAs were not increased by any of the treatments. In vitro enzyme activity assays demonstrated that 8PN and DIM, but not CUR or IXN, inhibited human CYP1A1, CYP1A2, and CYP3A4 activities. To distinguish between treatment effects on transcription versus direct effects on enzyme activity for DIM, we evaluated the effects of pretreatment alone (transcriptional activation) versus cotreatment alone (enzyme inhibition). The results demonstrated that effects on gene expression, but not catalytic activity, are responsible for the observed effects of DIM on AFB-DNA adduct formation. The increase in AFB-DNA damage following DIM treatment may be explained through its substantial induction of CYP1A2 and/or its downregulation of GSTM1, both of which were significant. The increase in DNA damage by DIM raises potential safety risks for dietary supplements of DIM and its precursor indole-3-carbinol.
Analysis and Estimation of Video QoE in Wireless Cellular Networks using Machine Learning (2019)

The use of video streaming services are increasing in the cellular networks, inferring a need to monitor video quality to meet users’ Quality of Experience (QoE). The so-called no-reference (NR) models for estimating video quality metrics mainly rely on packet-header and bitstream information. However, there are situations where the availability of such information is limited due to tighten security and encryption, which necessitates exploration of alternative parameters for conducting video QoE assessment. In this study we collect real-live in-smartphone measurements describing the radio link of the LTE connection while streaming reference videos in uplink. The radio measurements include metrics such as RSSI, RSRP, RSRQ, and CINR. We then use these radio metrics to train a Random Forrest machine learning model against calculated video quality metrics from the reference videos. The aim is to estimate the Mean Opinion Score (MOS), PSNR, Frame delay, Frame skips, and Blurriness. Our result show 94% classification accuracy, and 85% model accuracy (R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> value) when predicting the MOS using regression. Correspondingly, we achieve 89%, 84%, 85%, and 82% classification accuracy when predicting PSNR, Frame delay, Frame Skips, and Blurriness respectively. Further, we achieve 81%, 77%, 79%, and 75% model accuracy (R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> value) regarding the same parameters using regression.
An&lt;tex&gt;$O(N)$&lt;/tex&gt;Semipredictive Universal Encoder via the BWT (2004)

We provide an O(N) algorithm for a nonsequential semipredictive encoder whose pointwise redundancy with respect to any (unbounded depth) tree source is O(1) bits per state above Rissanen's lower bound. This is achieved by using the Burrows-Wheeler transform (BWT), an invertible permutation transform that has been suggested for lossless data compression. First, we use the BWT only as an efficient computational tool for pruning context trees, and encode the input sequence rather than the BWT output. Second, we estimate the minimum description length (MDL) source by incorporating suffix tree methods to construct the unbounded depth context tree that corresponds to the input sequence in O(N) time. Third, we point out that a variety of previous source coding methods required superlinear complexity for determining which tree source state generated each of the symbols of the input. We show how backtracking from the BWT output to the input sequence enables to solve this problem in O(N) worst case complexity.
Extensive Margin Adjustment of Multi-Product Firm and Risk Diversification (2017)

Product scope adjustment is a key mechanism through which multi-product firms achieve efficient resource allocations. In this paper, we take a novel perspective to study firms' product scope adjustment behavior through the lens of asset pricing. Using a unique panel scanner data set containing detailed information on products, matched with the financial information of their manufacturers, we find that multi-product firms with higher product turnover have lower financial risks and lower risk premia. To understand this channel, we propose a stylized model with a time-dependent (Calvo-type) product turnover rate to highlight the 'risk absorption channel' of product scope adjustment. In response to an economy-wide shock, a firm that can adjust its product scope more flexibly shows lower excess equity returns and lower asset volatility.
Fabrication of porous silicon membranes (1988)

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item.
Ancillary Ligand Effects upon Dithiolene Redox Noninnocence in Tungsten Bis(dithiolene) Complexes (2013)

An expanded set of compounds of the type [W(S2C2Me2)2L1L2](n) (n = 0: L1 = L2 = CO, 1; L1 = L2 = CN(t)Bu, 2; L1 = CO, L2 = carbene, 3; L1 = CO, L2 = phosphine, 4; L1 = L2 = phosphine, 5. n = 2-: L1 = L2 = CN(-), [6](2-)) has been synthesized and characterized. Despite isoelectronic formulations, the compound set reveals gradations in the dithiolene ligand redox level as revealed by intraligand bond lengths, υ(CCchelate), and rising edge energies in the sulfur K-edge X-ray absorption spectra (XAS). Differences among the terminal series members, 1 and [6](2-), are comparable to differences seen in homoleptic dithiolene complexes related by full electron transfer to/from a dithiolene-based MO. The key feature governing these differences is the favorable energy of the CO π* orbitals, which are suitably positioned to overlap with tungsten d orbitals and exert an oxidizing effect on both metal and dithiolene ligand via π-backbonding. The CN(-) π* orbitals are too high in energy to mix effectively with tungsten and thus leave the filled dithiolene π* orbitals unperturbed. This work shows how, and the degree to which, the redox level of a noninnocent ligand can be modulated by the choice of ancillary ligands(s).
The detection of disease relapse after radical treatment for prostate cancer (2013)

Nanni, Cristina; Schiavina, Riccardo; Rubello, Domenico; Ambrosini, Valentina; Brunocilla, Eugenio; Martorana, Giuseppe; Fanti, Stefano Author Information
Role of basal release of nitric oxide on coronary flow and mechanical performance of the isolated rat heart. (1992)

1. The role of nitric oxide (NO) in the regulation of coronary flow and mechanical function was studied in isolated working rat hearts. 2. The inhibition of basal release of NO by L-Ng-monomethylarginine (L-NMMA; 500 microM), a specific inhibitor of its synthesis, induced a reduction of coronary flow to 39.1% (+/- 3.4) of its basal level. 3. Associated with this was a drop of cardiac output to 58.10% (+/- 5.42) of control values. 4. This mechanical dysfunction, which was more pronounced in hypertrophied hearts, appears to be related to ischaemia, as it was prevented by simultaneously administered glyceryl trinitrate. Furthermore, L-NMMA did not alter the contractile activity of isolated cardiac myocytes, thereby excluding a direct toxic effect. 5. These findings provide evidence that NO plays a crucial role in the maintenance of basal coronary flow and appears to be essential for sustaining mechanical activity.
Androgen-Responsive Aspects of Cognition in Girls with Turner Syndrome (2003)

Turner syndrome (TS) represents a unique, sex hormone-deficient model in which to study the biological effects of androgen treatment (replacement) on cognition in females because TS girls have gonadal dysgenesis and absent ovarian androgen and estrogen production. We investigated the effects of androgen replacement therapy in TS girls, ages 10-14 yr, on cognitive function. A total of 64 TS girls were randomized to receive oxandrolone or placebo for 2 yr. They had a cognitive evaluation of four domains (verbal abilities, spatial cognition, executive function, and working memory) at baseline, 1, and 2 yr of the study. In addition, all subjects were examined for study safety every 6 months. Three of the four domains studied did not change significantly in response to oxandrolone treatment (verbal abilities, spatial cognition, and executive function). In contrast, the working memory summary score had a significant group by time interaction. The oxandrolone-treated group demonstrated improved performance after 2 yr, compared with the placebo group (P < 0.03). Minimal or no side effects were observed. In conclusion, oxandrolone treatment for 2 yr improves working memory in adolescent girls with TS. What this degree of improvement will mean in real life terms for TS girls remains to be determined.
ChemInform Abstract: PREPARATION AND PROPERTIES OF HEPTAFLUOROISOPROPYL BENZOATE AND BENZYL HEPTAFLUOROISOPROPYL ETHERS (1975)

Abstract Das aus Hexafluoraceton (I) und Fluoridionen gewonnene Isopropoxid‐Ion (II) setzt sich bei niedriger Temperatur mit Benzoylchlorid (III) zu dem‐ instabilen Ester (IV) um.
Genotype‐phenotype correlation of Coffin‐Siris syndrome caused by mutations in <i>SMARCB1</i>, <i>SMARCA4</i>, <i>SMARCE1</i>, and <i>ARID1A</i> (2014)

Coffin-Siris syndrome (CSS) is a rare congenital malformation syndrome, recently found to be caused by mutations in several genes encoding components of the BAF complex. To date, 109 patients have been reported with their mutations: SMARCB1 (12%), SMARCA4 (11%), SMARCE1 (2%), ARID1A (7%), ARID1B (65%), and PHF6 (2%). We review genotype-phenotype correlation of all previously reported patients with mutations in SMARCB1, SMARCA4, SMARCE1, and ARID1A through reassessment of their clinical and molecular findings. Cardinal features of CSS included variable degrees of intellectual disability (ID) predominantly affecting speech, sucking/feeding difficulty, and craniofacial (thick eyebrows, long eyelashes), digital (hypoplastic 5th fingers or toes, hypoplastic 5th fingernails or toenails), and other characteristics (hypertrichosis). In addition, patients with SMARCB1 mutations had severe neurodevelopmental deficits including severe ID, seizures, CNS structural abnormalities, and no expressive words as well as scoliosis. Especially, those with a recurrent mutation "p.Lys364del" represented strikingly similar phenotypes including characteristic facial coarseness. Patients with SMARCA4 mutations had less coarse craniofacial appearances and behavioral abnormalities. Patients with SMARCE1 mutations had a wide spectrum of manifestations from severe to moderate ID. Patients with ARID1A also had a wide spectrum of manifestations from severe ID and serous internal complications that could result in early death to mild ID. Mutations in SMARCB1, SMARCA4, and SMARCE1 are expected to exert dominant-negative or gain-of-function effects, whereas those in ARID1A are expected to exert loss-of-function effects.