gebhart/patrepeval huggingface dataset:
Determination of Interlaminar Toughness of IM7/977-2 Composites at Temperature Extremes and Different Thicknesses (2005)

Composite materials are being used in the aerospace industry as a means of reducing vehicle weight. In particular, polymer matrix composites (PMC) are good candidates due to their high strength-to-weight and high stiffness-to-weight ratios. Future reusable space launch vehicles and space exploration structures will need advanced light weight composites in order to minimize vehicle weight while demonstrating robustness and durability, guaranteeing high factors of safety. In particular, the implementation of composite cryogenic propellant fuel tanks (cryotanks) for future reusable launch vehicles (RLVs) could greatly reduce the vehicle's weight versus identically sized cryotanks constructed of metallic materials. One candidate composite material for future cryotank designs is IM7/977-2, which is a graphite/epoxy system. A successful candidate must demonstrate reasonable structural properties over a wide range of temperatures. Since the matrix material is normally the weak link in the composite, tests that emphasize matrix-dominated behavior need to be conducted. Therefore, the objective of this work is to determine the mode I interlaminar fracture toughness of unidirectional 8-ply and 16-ply IM7/977-2 through experimental testing. Tests were performed at -196 degrees Celsius (-320 degrees Fahrenheit), 22 degrees Celsius (72 degrees Fahrenheit), 93 degrees Celsius (200 degrees Fahrenheit) and 160 degrees C (320 degrees Fahrenheit). Low temperature testing was completed while the specimen was submerged in a liquid nitrogen bath. High temperature testing was completed in a temperature-controlled oven.
A Comparison of the Effects of Pegvisomant and Octreotide on Glucose, Insulin, Gastrin, Cholecystokinin, and Pancreatic Polypeptide Responses to Oral Glucose and a Standard Mixed Meal (2002)

Standard medical therapy for patients with acromegaly includes somatostatin analogs. Owing to the widespread expression of somatostatin receptors, these may be associated with unwanted effects, such as altered glucose tolerance and impaired gut hormone release. Pegvisomant is a novel pegylated GH analog that competes with wild-type GH for GH-receptor binding sites but contains a position 120, amino acid substitution that prevents functional GH receptor dimerization, a known prerequisite for GH signal transduction and generation of IGF-I. We have studied the short-term effects of these two therapies (pegvisomant 20 mg/d for 7 d and octreotide 50 microg thrice daily for 7 d) on glucose tolerance and stimulated gut hormone release in six healthy male volunteers in an open-label, random-order, cross-over study. Subjects were assessed at baseline (oral glucose tolerance test and standard mixed meal) and on d 6 and 7 of each therapy with a minimum washout of 2 wk between treatments. Area under the curve and peak responses were analyzed using one-way repeated-measures ANOVA (on ranks where appropriate). Pegvisomant had no effect on glucose tolerance or stimulated gut hormone response during an oral glucose tolerance test and a standard meal. In contrast, octreotide significantly increased fasting plasma glucose, lowered fasting plasma insulin, and led to deterioration in glucose tolerance; three subjects developed impaired glucose tolerance and one diabetes mellitus by World Health Organization criteria. Octreotide significantly impaired stimulated release of cholecystokinin, gastrin, insulin, and pancreatic polypeptide. In conclusion, pegvisomant, unlike octreotide, is not associated with deterioration in glucose tolerance and impairment of stimulated gut hormone release in normal males.
Stability of injection-locked oscillators (1972)

Injection-locked oscillators are increasingly being used as FM amplifiers. When the injection signal is large, as commonly used for FM amplifications, however, the first-order theory previously developed is inadequate. An alternative theory to determine the stability of locking with large signal injection is presented.
A new CAE procedure for railway wheel tribological design (2004)

New demands are being imposed on railway wheel wear and reliability to increase the time between wheel reprofiling, improve safety and reduce total wheelset lifecycle costs. In parallel with these requirements, changes in railway vehicle missions are also occurring. These have led to the need to operate rolling stock on track with low as well as high radius curves; increase speeds and axle loads; and contend with a decrease in track quality due to a reduction in maintenance. These changes are leading to an increase in the severity of the wheel/rail contact conditions, which may increase the likelihood of wear or damage occurring. \n\nThe aim of this work was to develop a new CAE design methodology to deal with these demands. The model should integrate advanced numerical tools for modelling of railway vehicle dynamics and suitable models to predict wheelset durability under typical operating conditions. This will help in designing wheels for minimum wheel and rail wear; optimising railway vehicle suspensions and wheel profiles; maintenance scheduling and the evaluation of new wheel materials. This work was carried out as part of the project HIPERWheel, funded by the European Community within the Vth Framework Programme.
A transposon-related palindromic repetitive sequence from<i>C. elegans</i> (1991)

A family of transposon-like sequences in the C. elegans genome is described. This family, termed the Tc6 family, consists mostly of conserved, 1.6 kb elements. Four Tc6 elements or partial elements have been cloned and the DNA sequences of three were determined. One appears to be a complete element of 1603 nucleotides, consisting of a palindrome of 765 nucleotides, with a central, non-palindromic region of 73 nucleotides. Another has an identical structure except for an internal deletion. A third is a partial element terminating at a probable internal restriction site used for cloning. A fourth clone contained portions of the Tc6 sequence juxtaposed to non-Tc6 sequences. All C. elegans strains examined contain 20-30 Tc6 elements. The ends of Tc6 elements are conserved and have sequence similarity to the ends of C. elegans transposons Tc1 and Tc3. The ends of Tc6 elements also have sequence similarity to the heptamer portion of the immunoglobulin and T-cell receptor recombination signal sequence, raising the possibility of wide phylogenetic conservation of the recombination mechanism. Tc6 elements also share sequence motifs with plant-pathogenic viroid RNA's, possibly indicative of a Tc6 RNA replicative phase.
SgxPectre Attacks: Leaking Enclave Secrets via Speculative Execution. (2018)

This paper presents SgxPectre Attacks that exploit the recently disclosed CPU bugs to subvert the confidentiality of SGX enclaves. Particularly, we show that when branch prediction of the enclave code can be influenced by programs outside the enclave, the control flow of the enclave program can be temporarily altered to execute instructions that lead to observable cache-state changes. An adversary observing such changes can learn secrets inside the enclave memory or its internal registers, thus completely defeating the confidentiality guarantee offered by SGX. To demonstrate the practicality of our SgxPectre Attacks, we have systematically explored the possible attack vectors of branch target injection, approaches to win the race condition during enclave's speculative execution, and techniques to automatically search for code patterns required for launching the attacks. Our study suggests that any enclave program could be vulnerable to SgxPectre Attacks since the desired code patterns are available in most SGX runtimes (e.g., Intel SGX SDK, Rust-SGX, and Graphene-SGX).
Peribulbar anaesthesia using a mixture of local anaesthetic and vecuronium (1998)

The aim of this double-blind, randomised study was to assess the effects of the addition of 0.5 mg of vecuronium bromide to a standard local anaesthetic mixture used for peribulbar anaesthesia. We studied 60 patients undergoing regional anaesthesia for intra-ocular surgery and were primarily interested in the quality of globe and lid akinesia. All received a mixture of 5 ml 2% lignocaine with 1:200,000 adrenaline, 5 ml 0.75% bupivacaine and 150 IU hyaluronidase with either 0.9% saline 0.25 ml (group A, n = 30) or vecuronium bromide 0.25 ml (0.5 mg) (group B, n = 30). Eye movements assessed at both 5 and 10 min were significantly reduced in the vecuronium group (group B) (p < 0.05). We conclude that the addition of vecuronium at a dose of 0.5 mg to the standard local anaesthetic mixture improves the quality of globe and lid akinesia.
The modified input-output algorithm for the synthesis of computer-generated holograms (1994)

A modified input-output (MIO) algorithm for the synthesis of computer-generated holograms is presented. The MIO algorithm corresponds to the input-output (IO) algorithm with a special adaptive gain. Experimental results indicate that significant improvement is achievable with the MIO algorithm due to convergence to a very deep minimum. In the case of designing quantized phase holograms, no matter how many levels of phase quantization are used, the MIO algorithm performs much better than the IO algorithm
Annotation and Extraction of Relations from Italian Medical Records. (2015)

We address the problem of extracting knowledge from large scale clinical records written in Italian by physicians. We perform recognition of relevant entities such as symptoms, diseases, treatments, measurements, drugs and so forth, and then we determine their semantic relations. We developed suitable training corpora in order to apply machine learning techniques to this task. We report on experiments performed on medical data provided in the context of a regional research project on technologies for health care.
Thiol functionalization of surfaces for biosensor development (1999)

The immobilization of biomolecules on substrate surfaces for biosensor development requires linking molecules that must meet a specific set of criteria. Two such agents based on bifunctional alkyltrichlorosilane structures, 1-bromo-11-(trichlorosilyl)-undecane and 1-(thiotrifluoroacetato)-11-(trichlorosilyl)-undecane, are employed to generate thiol-functionalized surfaces either by nucleophilic substitution followed by reduction (bromine-containing derivative) or deprotection (fluorine-containing compound). Both molecules have been attached to the surfaces of silicon wafers in conjunction with the diluent silane, octyltrichlorosilane. X-ray photoelectron spectroscopic analysis in the conventional and angle-resolved modes confirms that both silanization reactions were successful. The alkyl-bromine surfaces were subjected to treatment with a set of nucleophilic reactants followed by reduction and derivatization with trifluoroacetic anhydride. The latter in conjunction with surface analysis was used to estimate the level of thiol functionalization achieved. The fluorine-containing undecane surface has been studied by surface analysis both before and after deprotection of the thiol group by hydroxylamine solution. The results indicate that a high coverage of the surface was found for the protected moiety, with approximately 10% of the trifluoro acetate groups remaining after the deprotection procedure.Key words: bifunctional silanes, thiol surface functionalization, biomolecule immobilization, X-ray photoelectron spectroscopy.
A real‐time reconstruction system for magnetic resonance imaging (1996)

A digital-electronic reconstruction system for MRI has been designed and demonstrated. The system is capable of reconstructing a 128 x 128 pixel image from complex-valued data in approximately 8 ms (122 frames per second) or a 256 x 256 pixel image in 32 ms (30 frames per second) using the standard 2D FFT reconstruction algorithm. Real-time MR imaging can be obtained when this reconstruction system is coupled with fast continuous echo-planar type data acquisition. This provides the unique potential for real-time monitoring of interventional procedures or for rapid patient positioning. The real-time reconstruction system presented here consists of four main subsystems: an analog to digital converter, an interface memory, the Fourier processor, and the display processor. The basic design of this reconstruction system is presented along with results, demonstrating the capability of the system.
Taxonomy of Antarctic Flavobacterium species: description of Flavobacterium gillisiae sp. nov., Flavobacterium tegetincola sp. nov., and Flavobacterium xanthum sp. nov., nom. rev. and reclassification of [Flavobacterium] salegens as Salegentibacter salegens gen. nov., comb. nov. (2000)

16S rRNA phylogenetic analysis of a number of yellow- and orange-pigmented strains isolated from a variety of Antarctic habitats including sea ice, lakewater and cyanobacterial mats indicated a close relationship to the genus Flavobacterium but distinct from known Flavobacterium species. Phenotypic properties, DNA G+C content and whole-cell fatty acid profiles of the Antarctic strains were consistent with those of the genus Flavobacterium. DNA-DNA hybridization analysis indicated the presence of two distinct and novel genospecies each isolated from a different Antarctic habitat. From polyphasic taxonomic data it is proposed that the two groups represent new species with the following proposed names: Flavobacterium gillisiae (ACAM 601T) and Flavobacterium tegetincola (ACAM 602T). In addition polyphasic analysis of the species '[Cytophaga] xantha' (Inoue and Komagata 1976), isolated from Antarctic mud, indicated it was a distinct member of the genus Flavobacterium and was thus revived as Flavobacterium xanthum. Phylogenetic and fatty acid analyses also indicate that the species [Flavobacterium] salegens (Dobson et al. 1993), from Organic Lake, Antarctica, is misclassified at the genus level. It is proposed that this species belongs to a new genus, Salegentibacter salegens gen. nov., comb. nov.
Numerical Simulation of Reinforcement for Rock Slope with Rock Bolt (Anchor Cable) Frame Beam (2008)

As two new kinds of compound reinforcement facilities, rock bolt frame beam and anchor cable frame beam are widely used for reinforcement of rock slopes in recent years. However, past studies on the two facilities synthetically considering interactions among rock bolt (anchor cable), frame beam and rock masses are quite few. Coupled with 1-D elastic-plastic cable elements and 3-D elastic-plastic pole elements, 3-D linear-elastic beam elements were used to simulate the interactions between reinforcement and the reinforced rock slope. Influence of the reinforcement on the stability of one rock slope of an expressway was assessed on the basis of the simulation results. The results show that (1) both rock bolt reinforcement methods with or without frame beam are helpful for the improvement of the stability of surface layer of the slope in terms of displacement and stress distribution, but deformation on the slope surface is significantly reduced with frame beam; (2) fields of the displacements and stresses in the slope are greatly related to the layout of the cables and the design magnitude of the prestress. Therefore, reinforcement of prestressed anchor cable coupled with frame beam is one of the most effective methods to improve the stability of the studied slope.
Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children? (1996)

These findings suggest that maternal smoking during pregnancy is a risk factor for ADHD. If confirmed, these findings will stress the importance of programs aimed at smoking prevention in nonsmoking women and smoking cessation in smoking women of childbearing age.
Effect of Metoclopramide in Diabetic Gastroparesis (1985)

The aims of our study were to: determine the effect of metoclopramide parenterally and orally on delayed gastric emptying of a radionuclide test meal in symptomatic patients with diabetic gastroparesis not explained by ulceration or other mechanical problems; and evaluate in a double-blind crossover fashion the efficacy of metoclopramide in relieving the symptoms of diabetic gastroparesis. Thirteen patients with subjective evidence of gastric stasis had delayed gastric emptying of an isotope-labeled semisolid meal which was significantly accelerated (p less than 0.05) after 10 mg of metoclopramide parenterally. Patients then received metoclopramide 10 mg and placebo before meals and prior to retiring for 3 weeks in a randomized double-blind crossover design. During metoclopramide therapy nausea, vomiting, anorexia, fullness, and bloating were significantly (p less than 0.05) ameliorated compared to placebo with an overall mean symptom reduction of 52.6%. Gastric emptying studies after completion of the trial is seven patients, subjectively improved and receiving open-labeled metoclopramide, showed significantly less gastric retention. Individual improvements in gastric emptying after parenteral or oral metoclopramide, however, could not be correlated with symptom change during the treatment trial. We conclude that metoclopramide is an important therapeutic adjunct in the management of diabetic gastroparesis and its therapeutic effects are mediated through its prokinetic properties as well as centrally mediated antiemetic actions.
Depletion and Bioavailability of [14C]Furazolidone Residues in Swine Tissues (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDepletion and Bioavailability of [14C]Furazolidone Residues in Swine TissuesDavid W. Gottschall and Richard WangCite this: J. Agric. Food Chem. 1995, 43, 9, 2520–2525Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/jf00057a037https://doi.org/10.1021/jf00057a037research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Extreme Vertices Designs for Linear Mixture Models (1974)

Extreme vertices designs are useful in experimentation with mixtures, particularly when the response can be described by a linear model. An algorithm is proposed for selecting a subset of extreme vertices when the number of candidate vertices is large. This algorithm has been found to produce designs which generally have small trace (X'X)−1, indicating the average variance of the estimated coefficients in the linear model will be small.
Epithelial injury induces Egr-1 and Fos expression by a pathway involving protein kinase C and ERK (1999)

The signaling pathways activated in response to gastrointestinal injury remain poorly understood. Previous work has implicated the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase as a mediator of wound-signal transduction and a possible regulator of epithelial restitution. Monolayer injury resulted in rapid activation of p42 and p44 ERK. Injury-induced ERK activation was blocked by protein kinase C inhibition or by disruption of the cell cytoskeleton. Significant increases in Fos and early growth response (Egr)-1 mRNA levels were stimulated by injury, peaking by 20 min. ERK activation and the induction of Egr-1 mRNA were inhibited in a dose-dependent fashion with PD-98059. Fos mRNA expression was partially blocked by PD-98059. Western blot analysis demonstrated strong expression and nuclear localization of Fos and Egr after wounding. Electrophoretic mobility shift assays demonstrated that nuclear extracts contained a protein that specifically bound double-stranded oligonucleotides containing the Egr consensus binding element. Gel supershift assays demonstrated that the protein-DNA complexes were recognized by anti-Egr antibody. Inhibition of injury-induced ERK activation by PD-98059 or direct interference with Egr by expression of a dominant negative mutant led to significantly reduced in vitro monolayer restitution.
Studien zur Chemie O,N‐ und S,N‐haltiger Heterocyclen, 10. Mitt<sup>1)</sup>: Synthese und biologische Aktivität von 2‐substituierten 2‐Ethylbenzoxazolen (1991)

2-Vinylbenzoxazole (3) is obtained by condensation of acrylic acid with 2-aminophenol in a mixture of phosphorus pentoxide/methansulfonic acid. Interaction of 3 with N-, O-, and C-nucleophiles yields 2-substituted 2-ethyl-benzoxazoles. Compounds 8a, 8b and 8e show analgetic activity in mice. Moreover, fungicide, insecticide and nematocide activity of some compounds is found.
Orthogonal “Relay” Reactions for Designing Functionalized Soft Nanoparticles (2009)

The combination of reversible addition-fragmentation chain transfer (RAFT) chemistry followed by thiol-based "click" chemistry, known as an orthogonal "relay" reaction as one step complements the other, was used to produce surface-functionalized soft nanoparticles. Thiocarbonyl thio compounds were first used in the presence of vinyl monomers and a source of radicals to control the growth of the polymeric chains (via the RAFT process) and then reduced to thiols and utilized as a handle for functionalization of the resulting polymer chain ends (via a thiol-based click reaction). Both reactions occur under mild conditions and offer excellent control over the properties of the final product, and the thiol addition shows all the benefits of a click reaction, without requiring the use of a catalyst. This simple chemistry opens up the route to the production of a wide range of functional materials, and the concept is illustrated by the formation of nanoparticle-based gels, fluorescent-tagged particles, and protein-nanoparticle conjugates.
Long‐term intensive electrically stimulated cycling by spinal cord–injured people: Effect on muscle properties and their relation to power output (2008)

Inactivity and muscular adaptations following spinal cord injury (SCI) result in secondary complications such as cardiovascular disease, obesity, and pressure sores. Functional electrically stimulated (FES) cycling can potentially reduce these complications, but previous studies have provided inconsistent results. We studied the effect of intensive long-term FES cycle training on muscle properties in 11 SCI subjects (mean +/- SEM: 41.8 +/- 2.3 years) who had trained for up to 1 hour/day, 5 days/week, for 1 year. Comparative measurements were made in 10 able-bodied (AB) subjects. Quadriceps maximal electrically stimulated torque increased fivefold (n = 5), but remained lower than in AB individuals. Relative force response at 1 HZ decreased, relaxation rate remained unchanged, and fatigue resistance improved significantly. Power output (PO) improved to a lesser extent than quadriceps torque and not to a greater extent than has been reported previously. We need to understand the factors that limit PO in order to maximize the benefits of FES cycling.