gebhart/patrepeval huggingface dataset:
Pertussis toxin blocks both cyclic AMP-mediated and cyclic AMP-independent actions of somatostatin. Evidence for coupling of Ni to decreases in intracellular free calcium. (1985)

The neuropeptide somatostatin inhibits hormone release from GH4C1 pituitary cells via two mechanisms: inhibition of stimulated adenylate cyclase and a cAMP-independent process. To determine whether both mechanisms involve the guanyl nucleotide-binding protein Ni, we used pertussis toxin, which ADP-ribosylates Ni and thereby blocks its function. Pertussis toxin treatment of GH4C1 cells blocked somatostatin inhibition of both vasoactive intestinal peptide (VIP)-stimulated cAMP accumulation and prolactin secretion. In membranes prepared from toxin-treated cells, somatostatin inhibition of VIP-stimulated adenylate cyclase activity was reduced and 125I-Tyr1-somatostatin binding was decreased more than 95%. In contrast, pertussis toxin did not affect the biological actions or the membrane binding of thyrotropin-releasing hormone. These results indicate that ADP-ribosylated Ni cannot interact with occupied somatostatin receptors and that somatostatin inhibits VIP-stimulated adenylate cyclase via Ni. To investigate somatostatin's cAMP-independent mechanism, we used depolarizing concentrations of K+ to stimulate prolactin release without altering intracellular cAMP levels. Measurement of Quin-2 fluorescence showed that 11 mM K+ increased intracellular [Ca2+] within 5 s. Somatostatin caused an immediate, but transient, decrease in both basal and K+-elevated [Ca2+]. Consistent with these findings, somatostatin inhibited K+-stimulated prolactin release, also without affecting intracellular cAMP concentrations. Pertussis toxin blocked the somatostatin-induced reduction of [Ca2+]. Furthermore, the toxin antagonized somatostatin inhibition of K+-stimulated and VIP-stimulated secretion with the same potency (ED50 = 0.3 ng/ml). These results indicate that pertussis toxin acts at a common site to prevent somatostatin inhibition of both Ca2+- and cAMP-stimulated hormone release. Thus, Ni appears to be required for somatostatin to decrease both cAMP production and [Ca2+] and to inhibit the actions of secretagogues using either of these intracellular messengers.
A note on least squares methods (2005)

We examine the relationship of preconditioned L2 residual, Sobolev gradient and H−1 least squares methods. Of particular interest are: (1) a demonstration that the Sobolev gradient approach is simply a form of preconditioning for the standard L2 scheme, and (2) that the Sobolev preconditioner is related to the additional solve step in the H−1 formulation. Copyright © 2005 John Wiley & Sons, Ltd.
Learning algorithms for feedforward networks based on finite samples (1996)

We present two classes of convergent algorithms for learning continuous functions and regressions that are approximated by feedforward networks. The first class of algorithms, applicable to networks with unknown weights located only in the output layer, is obtained by utilizing the potential function methods of Aizerman et al. (1970). The second class, applicable to general feedforward networks, is obtained by utilizing the classical Robbins-Monro style stochastic approximation methods (1951). Conditions relating the sample sizes to the error bounds are derived for both classes of algorithms using martingale-type inequalities. For concreteness, the discussion is presented in terms of neural networks, but the results are applicable to general feedforward networks, in particular to wavelet networks. The algorithms can be directly adapted to concept learning problems.
High-Resolution Angle-of-Arrival Measurements on Physically-Nonstationary Mobile Radio Channels (2008)

A high-resolution measurement system for the characterization of the delay and angle-of-arrival properties of all significant multipath components on mobile radio channels is presented. The system uses complex impulse response data obtained from a novel 3-D tilted cross switched antenna array as input to an improved version of 3-D Unitary ESPRIT. Results from simulations and measurements show that the approach is capable of accurately characterizing the delay and angle-of-arrival characteristics of the dominant multipath components at moderate urban speeds along a trajectory in mobile propagation environments with high resolution in both azimuth and elevation.
Modeling the splash of a droplet impacting a solid surface (2000)

A numerical model is used to simulate the fingering and splashing of a droplet impacting a solid surface. A methodology is presented for perturbing the velocity of fluid near the solid surface at a time shortly after impact. Simulation results are presented of the impact of molten tin, water, and heptane droplets, and compared with photographs of corresponding impacts. Agreement between simulation and experiment is good for a wide range of behaviors. An expression for a splashing threshold predicts the behavior of the molten tin. The results of water and especially heptane, however, suggest that the contact angle plays an important role, and that the expression may be applicable only to impacts characterized by a relatively low value of the Ohnesorge number. Various experimental data of the number of fingers about an impacting droplet agree well with predictions of a previously published correlation derived from application of Rayleigh–Taylor instability theory.
[Preservation of bread and pastry products in a controlled atmosphere]. (1978)

Industrial soft pastries and the various breads are cereals products containing a humidity which is favorable to the development of mouldiness. Different or various methods of conservation has been attempted. One interesting approach to the problem is packaging in controlled atmosphere. It requires adequate machinery and suitable conditioning materials. Jardry-Buquet and Hayssen's machines are rapidly described as well as some of the packing film used for making air-tight bags. Bad results were observed with nitrogen, argon and a mixture of nitrogen-carbon dioxide. The satisfactory results obtained with the nitrous oxide for cakes (especially fruit-cakes) and for the bread with a mixture of ethylene oxide-carbon dioxide are: a good conservation for a period of 4 to 6 months in both cases. Organoleptic qualities of the products are not significantly diminished after eight weeks of preservation. The gases contained on the bags are analysed at different periods and the progressive disappearance of the nitrous oxide as well as the athylene dioxide was measured. The compounds derivated from these gases were researched on different extracts. No derivatives of the nitrous oxide were observed. From the ethylene oxide, the derivatives found in the bread are diethylene glycol and 2-chloroethanol; their concentrations are respectively 100 and 300 ppm in the case of 85 : 15 mixture, but decrease to a mere trace and 45 ppm in the case of 98 : 2 mixture. The measure of humidity, of peroxides and of the staleness of crumb are favourable for a good conservation.
THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION (1996)

Conference Abstract| November 01 1996 THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION Avram Hershko Avram Hershko 1Technion-Israel Institute of Technology, Haifa, 31096, Israel Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1996) 24 (4): 627S. https://doi.org/10.1042/bst024627sc Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Avram Hershko; THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION. Biochem Soc Trans 1 November 1996; 24 (4): 627S. doi: https://doi.org/10.1042/bst024627sc Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1996 Biochemical Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
Atypical Protein Kinase Cs Are the Ras Effectors That Mediate Repression of Myogenic Satellite Cell Differentiation (2002)

Oncogenic Ha-Ras is a potent inhibitor of skeletal muscle cell differentiation, yet the Ras effector mediating this process remains unidentified. Here we demonstrate that the atypical protein kinases (aPKCs; lambda and/or zeta) are downstream Ras effectors responsible for Ras-dependent inhibition of myogenic differentiation in a satellite cell line. First, ectopic expression of Ha-RasG12V induces translocation of PKClambda from the cytosol to the nucleus, suggesting that aPKCs are activated by Ras in myoblasts. The aPKCs function as downstream Ras effectors since inhibition of aPKCs by expression of a dominant negative PKCzeta mutant or by treatment of cells with an inhibitor, GO6983, promotes myogenesis in skeletal muscle satellite cells expressing oncogenic Ha-Ras. Arresting cell proliferation synergistically enhances myogenic differentiation only when aPKCs are also inhibited. Thus, the repression of myogenic differentiation in a satellite cell line appears to be directly mediated by aPKCs acting as Ras effectors and indirectly mediated via stimulation of cell proliferation.
A Neural Model of Figure–Ground Organization (2007)

Psychophysical studies suggest that figure-ground organization is a largely autonomous process that guides--and thus precedes--allocation of attention and object recognition. The discovery of border-ownership representation in single neurons of early visual cortex has confirmed this view. Recent theoretical studies have demonstrated that border-ownership assignment can be modeled as a process of self-organization by lateral interactions within V2 cortex. However, the mechanism proposed relies on propagation of signals through horizontal fibers, which would result in increasing delays of the border-ownership signal with increasing size of the visual stimulus, in contradiction with experimental findings. It also remains unclear how the resulting border-ownership representation would interact with attention mechanisms to guide further processing. Here we present a model of border-ownership coding based on dedicated neural circuits for contour grouping that produce border-ownership assignment and also provide handles for mechanisms of selective attention. The results are consistent with neurophysiological and psychophysical findings. The model makes predictions about the hypothetical grouping circuits and the role of feedback between cortical areas.
Using i/sup 2/F as a data collector for a TIRS-based expert system (Integrated Interface Facility) (2002)

Console automation techniques are important in the overall effort to automate the operation of IBM mainframe systems. i/sup 2/F (Integrated Interface Facility) is an OS/2 application that allows construction of a programmed interface to communication networks, TIRS (The Integrated Reasoning Shell) is a multiplatform expert shell. The authors examine how i/sup 2/F can be used to collect data to support TIRS reasoning in a console automation expert system. The system described allows the gathering of data to be separated from the reasoning process, allowing flexibility in building and implementing the system. The skills required for building the knowledge base and i/sup 2/F components are quite different. By making a clear separation between the what and how of data collection, support staff are used more efficiently. In addition, enterprise policies replicated in a variety of TIRS knowledge bases can support the system without alteration. The departmental procedures added in i/sup 2/F provide the elasticity for cultural and technological differences.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Framework for TCP Throughput Testing (2011)

This memo describes a methodology for measuring sustained TCP
throughput performance in an end-to-end managed network environment.
This memo is intended to provide a practical approach to help users
validate the TCP layer performance of a managed network, which should
provide a better indication of end-user application level experience.
In the methodology, various TCP and network parameters are identified
that should be tested as part of the network verification at the TCP
layer.
Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits (1993)

Oxygen tension was measured using flexible polarographic microelectrodes within the oviductal and uterine lumen in rhesus monkeys (n = 9), golden hamsters (n = 21) and rabbits (n = 6), during the reproductive cycle (monkey), during oestrus and pseudopregnancy (hamsters, rabbits) and during pregnancy (hamsters). In general, oxygen tensions in each species were much less than half of atmospheric O2, ranging from high values of about 60 mm Hg (8.7% O2) in the rabbit oviduct, rabbit and hamster uterus, to as low as 11 mm Hg (1.5% O2) in the monkey uterus. Oxygen tensions did not vary significantly between left and right sides of the reproductive tracts (all species), nor between pregnant and pseudopregnant states nor between oviduct and uterus (hamsters). Differences owing to reproductive stage were found in the monkey oviduct, hamster oviduct and uterus, and rabbit uterus. Oxygen tensions were consistently very low (11-14 mm Hg) in the monkey uterus throughout the menstrual cycle. In hamsters and rabbits, intrauterine O2 decreased significantly at about the normal time of blastocyst formation and implantation, to 37 mm Hg (5.3% O2) and 24 mm Hg (3.5% O2), respectively. This study indicates that embryos develop in vivo under low oxygen concentrations, especially during the peri-implantation period. The data have implications for investigations of embryo metabolism and for improving embryo development in vitro.
New books and multimedia (2013)

The New Books and Multimedia column contains brief reviews of new books in the fields of computer networks, communications networks, and wireless networks. Each review includes a highly abstracted description of the contents, relying on the publisher's descriptive materials, minus advertising superlatives, and checked for accuracy against a copy of the book. The reviews also comment on the structure and the target audience of each book. Publishers wishing to have their books listed in this manner should contact Yu Cheng at the email address below. Appropriate books will be reviewed in the column.
A 10MS/s 11-b 0.19mm/sup 2/ Algorithmic ADC with Improved Clocking (2006)

A 10Ms/s 11-b algorithmic ADC with an active area of 0.19mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2 </sup> is presented. Using an improved clocking scheme, this design overcomes the speed limit of algorithmic ADCs. The proposed ADC employs amplifier sharing, DC offset cancellation, and input memory effect suppression to reduce area and power, and achieve high linearity. The ADC implemented in a 0.13mum thick gate-oxide CMOS process achieves 69dB SFDR, 58dB SNR, and 56dB SNDR, while consuming 3.5mA from 3V supply
How Can I Teach My Children To Do Chores (2001)

How Can I Teach My Children To DoChores?
Asymmetric bioreduction of activated carbon–carbon double bonds using Shewanella yellow enzyme (SYE-4) as novel enoate reductase (2012)

Shewanella yellow enzyme (SYE-4), a novel recombinant enoate reductase, was screened against a variety of different substrates bearing an activated double bond, such as unsaturated cyclic ketones, diesters, and substituted imides. Dimethyl- and ethyl esters of 2-methylmaleic acid were selectively reduced to (R)-configured succinic acid derivatives and various N-substituted maleimides furnished the desired (R)-products in up to >99% enantiomeric excess. Naturally occurring (+)-carvone was selectively reduced to (-)-cis-dihydrocarvone and (-)-carvone was converted to the diastereomeric product, respectively. Overall SYE-4 proved to be a useful biocatalyst for the selective reduction of activated C = C double bonds and complements the pool of synthetic valuable enoate reductases.
Calpain Inhibition Protects against Virus-Induced Apoptotic Myocardial Injury (2001)

Viral myocarditis is an important cause of human morbidity and mortality for which reliable and effective therapy is lacking. Using reovirus strain 8B infection of neonatal mice, a well-characterized experimental model of direct virus-induced myocarditis, we now demonstrate that myocardial injury results from apoptosis. Proteases play a critical role as effectors of apoptosis. The activity of the cysteine protease calpain increases in reovirus-infected myocardiocytes and can be inhibited by the dipeptide alpha-ketoamide calpain inhibitor Z-Leu-aminobutyric acid-CONH(CH(2))3-morpholine (CX295). Treatment of reovirus-infected neonatal mice with CX295 protects them against reovirus myocarditis as documented by (i) a dramatic reduction in histopathologic evidence of myocardial injury, (ii) complete inhibition of apoptotic myocardial cell death as identified by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling, (iii) a reduction in serum creatine phosphokinase, and (iv) improved weight gain. These findings are the first evidence for the importance of a calpain-associated pathway of apoptotic cell death in viral disease. Inhibition of apoptotic signaling pathways may be an effective strategy for the treatment of viral disease in general and viral myocarditis in particular.
Phase III Randomized Intergroup Trial of CHOP Plus Rituximab Compared With CHOP Chemotherapy Plus <sup>131</sup> Iodine-Tositumomab for Previously Untreated Follicular Non-Hodgkin Lymphoma: SWOG S0016 (2012)

There was no evidence of a significant improvement in PFS comparing CHOP-RIT with CHOP-R. However, PFS and OS were outstanding on both arms of the study. Future studies are needed to determine the potential benefits of combining CHOP-R induction chemotherapy with RIT consolidation and/or extended rituximab maintenance therapy.
Low basal transcription of genes for tissue-specific collagens by fibroblasts and lymphoblastoid cells. Application to the characterization of a glycine 997 to serine substitution in alpha 1(II) collagen chains of a patient with spondyloepiphyseal dysplasia (1991)

Cultured dermal fibroblasts were shown, using amplification of cDNA by the polymerase chain reaction, to produce very low levels of spliced transcripts from the COL2A1 gene that encodes the cartilage-specific alpha 1(II) chains of type II collagen. Cultured lymphoblastoid cells were also shown to produce very low levels of spliced transcripts from the COL1A1 and COL1A2 genes that encode the alpha 1(I) and alpha 2(I) chains of type I collagen, the COL2A1 gene that encodes type II collagen, and the COL3A1 gene that encodes the alpha 1(III) chains of type III collagen. Amplified cDNAs prepared from lymphoblastoid cells were used to identify previously characterized heterozygous mutations in the COL1A1 and COL1A2 genes from two patients with osteogenesis imperfecta and in the COL3A1 gene from a patient with the Ehlers-Danlos syndrome type IV. Amplified alpha 1(II) cDNA from fibroblasts and lymphoblastoid cells of a child with spondyloepiphyseal dysplasia congenita was also used to localize sequence mismatches using chemical modification of cDNA:cDNA heteroduplexes by hydroxylamine and cleavage with piperidine. The amplification products containing the mismatched region were sequenced and the mutation was shown to change the codon GGC for glycine 997 to AGC for serine in the triple helical domain of the alpha 1(II) chains. The corresponding region of the genomic DNA was sequenced and the heterozygous point mutation was shown to be in exon 48 of the COL2A1 gene. Allelic restriction mapping showed that neither parent carried the mutation in their leucocytes. This mutation emphasizes the importance of COL2A1 mutations in producing the spondyloepiphyseal dysplasia phenotype. The low basal rate of transcription ("illegitimate transcription"), splicing, and polyadenylation of tissue-specific mRNAs by cultured dermal fibroblasts and lymphoblastoid cells provides the opportunity to localize and sequence mutations in amplified cDNA in patients from whom affected tissue is unavailable.
Design and biomechanical study of a modified pedicle screw. (2010)

The modified screw is well-designed and biomechanically improved. And it can provide sufficient stability for segment fixation as monoaxial screws.
Towards the development of a systematic approach for voltage stability assessment of large-scale power systems (1996)

This paper deals with the development of a systematic approach to voltage stability assessment of large-scale power systems. A brief description of the different tools for voltage stability analysis is given first, then a systematic procedure which addresses some important practical issues is proposed. Presentation of analysis tools is focused on the VSTAB and ETMSP programs. Finally, a large-scale case study is presented illustrating the proposed procedure.
Design and qualification of hermetically packaged lithium niobate optical modulator (2002)

Applications for lithium niobate modulators have developed in CATV, telephone and data communications markets. With deployment of devices in these systems comes the need to ensure long term reliability. In this paper we described the design, assembly, and qualification of a hermetically packaged optical modulator. The qualification devices were fabricated using a pilot production facility running at Lucent Technologies-Bell Laboratories. A variety of techniques are used to hermetically seal the Kovar package. The effects of thermal expansion mismatch between the package and the die are managed by careful package design and assembly operations. The package assembly employs a modular design which allows qualification of the subassemblies as well as the entire modulator. This design modularity allows fiber subassemblies and the lithium niobate die to be characterized for optical and mechanical performance before they are incorporated into the packaged modulator.
A declarative framework for adaptable applications in heterogeneous environments (2004)

In this paper we present an approach for developing adaptable software applications. The problem we are facing is that of a (possibly mobile) user who wants to download and execute an application from a remote server. The user's hosting device can be of different kinds (laptops, personal digital assistants, cellular phones, communicators, etc.) with specific hardware and software capabilities. The problem is to be able to decide whether the user's current device characteristics are compatible with the application requirements in order to prevent execution failures. In the negative case we want to identify the reasons that determined the incompatibility and perform an automatic adaptation of the application, so that it can match the user's device capabilities. We adopt a declarative approach: we provide each device with a declarative description of its characteristics and, possibly, context constraints. Inspired by Proof Carrying Code (PCC), we use first-order logic formulae to model both the behavior of the code, with respect to the properties of interest, and the execution context. The adaptation process is carried out by using theorem proving techniques, in particular, the proof assistant HOL4. The aim is to derive a formal proof which asserts that the behavior of the code can be correctly adapted to the given context. By construction, the proof, if it exists, gives information on how the adaptation has to be done. On the application side, Java2 Micro Edition (J2ME) is the chosen reference application development environment.
Über 1‐Phenoxy‐2‐äthoxy‐äthen (1953)

Abstract Die Darstellung des 1‐Phenoxy‐2‐äthoxy‐äthens durch katalytische Alkoholabspaltung aus dem Phenoxyacetaldehyd‐diäthylacetal und die Trennung in das cis ‐ und trans ‐Isomere werden beschrieben.