gebhart/patrepeval huggingface dataset:
Nuclear Integration of Glucocorticoid Receptor and Nuclear Factor-κB Signaling by CREB-binding Protein and Steroid Receptor Coactivator-1 (1998)

The p65 (RelA) component of nuclear factor-kappaB (NF-kappaB) and the glucocorticoid receptor (GR) mutually repress each other's ability to activate transcription. Both of these transcriptional activators depend upon the coactivators CREB-binding protein (CBP) and steroid receptor coactivator-1 (SRC-1) for maximal activity. Here we show that increased levels of CBP relieves the inhibition of glucocorticoid-mediated repression of NF-kappaB activity and the NF-kappaB-mediated repression of GR activity. SRC-1 can relieve the NF-kappaB-mediated repression of GR activity. We propose that cross-talk between the p65 component of NF-kappaB and glucocorticoid receptors is due, at least in part, to nuclear competition for limiting amounts of the coactivators CBP and SRC-1, thus providing a novel mechanism for decreasing expression of genes involved in the inflammatory response.
CEA‐CAM‐1 positive stem cells from the brain of the adult pig (2009)

Carcinoembryonic antigen‐cell adhesion molecule‐1 (CEA‐CAM‐1) positive stem cells have been visualized in the white matter and gray matter in the cerebral cortex of adult rats. Similar cells have also been isolated and characterized from the skeletal muscle of and peripheral vasculature of adult mammals, including humans. The current study was undertaken to determine the location of these cells with respect to the brains of the adult pig. Adult pigs were euthanized following the guidelines of Fort Valley State University's IACUC. The heads were fixed by immersion fixation, the brains isolated, cryosectioned and stained with an antibody diagnostic for adult pluripotential stem cells, i.e. CEA‐CAM‐1. The current study will discuss the location with respect to the white and gray natter in the adult pig. Studies are ongoing to address their functional significance in neuronal injury and repair.
Novel System Architecture and Waveform Design for Cognitive Radar Radio Networks (2012)

A novel approach to combining communication and radar functionalities in a single waveform design for cognitive radar radio (CRR) networks is proposed. This approach aims at extracting the target parameters from the radar scene, as well as facilitating high-data-rate communications between CRR nodes, by adopting a single waveform optimization solution. The system design technique addresses the coexisting communication and radar detection problems in mission-critical services, where there is a need of integrating the knowledge about the target scene gained from distinct radar entities functioning in tandem with each other. High spatial resolution and immunity to multipath fading make ultrawideband (UWB) signals an appropriate choice for such applications. The proposed solution is achieved by applying the mutual-information-based strategy to design the sequence of UWB transmission pulses and embed into them the communication data with the pulse position modulation scheme. With subsequent iterations of the algorithm, simulation results demonstrate an improvement in extraction of the parameters from the radar scene, such as target position and impulse response, while still maintaining high-throughput radio links with low bit error rates between CRR nodes.
Light source modeling for utilization in asymmetric reflector design for even surface illumination (2016)

Currently, luminaires optics are designed using simulation applications. These applications have models of light sources, which have a significant impact on calculations results accuracy. Adaptation of a model of a light source to an optical system of analysis, or proposition of a new model could have a meaningful impact. The article describes the author's innovative model of a light source to be used in calculations of asymmetric specular trough-shaped reflector ensuring uniform surface illumination of an object. Results show more accuracy in relation to commercial calculation tool and much shorter calculation time. It speeds up and simplifies significantly design process based on simulation calculations.
Novel Electrochromic Displays Using Monodisperse Viologen‐Modified Porous Polymeric Microspheres (2006)

Abstract Summary: In order to achieve a reasonable response time in an electrochromic display, viologen‐modified porous polymeric microspheres of various porosities have been used as substrates. Porous microspheres are prepared using seeded polymerization in the presence of a porogen. Based on ionic conductivity and the chronocoulometry measurements, it is confirmed that the electrolyte content increases, and the resistance of the polymer particles in the device decreases as the specific surface area of the porous particles increases. This results in a rapid response time of 270 ms. Schematic representation of the viologen‐modified porous polymeric microspheres in the manufactured ECD device (A). Images of the device (B) in the OFF state (left) and in the ON state (right). magnified image Schematic representation of the viologen‐modified porous polymeric microspheres in the manufactured ECD device (A). Images of the device (B) in the OFF state (left) and in the ON state (right).
Über die Verteilung von Radioyttrium und radioaktiven Seltenen Erden im Säugerorganismus III. Stoffwechseluntersuchungen an Mäusen und Meerschweinchen mit Radiocer (<sup>144</sup>Ce — <sup>144</sup>Pr) (1961)

Es wird über die Verteilung und Ausscheidung von 144 Ce— 144 Pr nach parenteraler Applikation bei Mäusen und Meerschweinchen berichtet. Eine Variation des p ʜ -Wertes der Injektionslösung sowie ein Zusatz inaktiven isotopen Trägermaterials beeinflußt deutlich das Stoffwechselverhalten des untersuchten Radionuklids. Auf die hohe Speicherung des Radiocers in der Leber während der ersten Tage nach der Inkorporation wird besonders hingewiesen.
XMPP: The Definitive Guide (2009)

This practical book provides everything you need to know about the Extensible Messaging and Presence Protocol (XMPP) -- the open technology for real-time communication used in instant messaging, Voice over IP, real-time collaboration, social networking, microblogging, lightweight middleware, cloud computing, and more. XMPP: The Definitive Guide walks you through the thought processes and design decisions involved in building a complete XMPP-enabled application, and adding real-time interfaces to existing applications.
Back to the Future: Learning Shape Models from 3D CAD Data (2010)

Recognizing 3D objects from arbitrary view points is one of the\nmost fundamental problems in computer vision. A major challenge lies\nin the transition between the 3D geometry of objects and 2D\nrepresentations that can be robustly matched to natural images. Most\napproaches thus rely on 2D natural images either as the sole source of\ntraining data for building an implicit 3D representation, or by\nenriching 3D models with natural image features.\nIn this paper, we go back to the ideas from the early days of computer\nvision, by using 3D object models as the only source of information for\nbuilding a multi-view object class detector. In particular, we use\nthese models for learning 2D shape that can be robustly matched to 2D\nnatural images. Our experiments confirm the validity of our approach,\nwhich outperforms current state-of-the-art techniques on a multi-view\ndetection data set.
KLC1-ALK: A Novel Fusion in Lung Cancer Identified Using a Formalin-Fixed Paraffin-Embedded Tissue Only (2012)

The promising results of anaplastic lymphoma kinase (ALK) inhibitors have changed the significance of ALK fusions in several types of cancer. These fusions are no longer mere research targets or diagnostic markers, but they are now directly linked to the therapeutic benefit of patients. However, most available tumor tissues in clinical settings are formalin-fixed and paraffin-embedded (FFPE), and this significantly limits detailed genetic studies in many clinical cases. Although recent technical improvements have allowed the analysis of some known mutations in FFPE tissues, identifying unknown fusion genes by using only FFPE tissues remains difficult. We developed a 5'-rapid amplification of cDNA ends-based system optimized for FFPE tissues and evaluated this system on a lung cancer tissue with ALK rearrangement and without the 2 known ALK fusions EML4-ALK and KIF5B-ALK. With this system, we successfully identified a novel ALK fusion, KLC1-ALK. The result was confirmed by reverse transcription-polymerase chain reaction and fluorescence in situ hybridization. Then, we synthesized the putative full-length cDNA of KLC1-ALK and demonstrated the transforming potential of the fusion kinase with assays using mouse 3T3 cells. To the best of our knowledge, KLC1-ALK is the first novel oncogenic fusion identified using only FFPE tissues. This finding will broaden the potential value of archival FFPE tissues and provide further biological and clinical insights into ALK-positive lung cancer.
A ratiometric fluorescent molecular probe for visualization of mitochondrial temperature in living cells (2015)

Mitochondrial thermodynamics is the key to understand cellular activities related to homeostasis and energy balance. Here, we report the first ratiometric fluorescent molecular probe (Mito-RTP) that is selectively localized in the mitochondria and visualize the temperature. We confirmed that Mito-RTP could work as a ratiometric thermometer in a cuvette and living cells.
Signal‐Off and Signal‐On Design for a Label‐Free Aptasensor Based on Target‐Induced Self‐Assembly and Abasic‐Site‐Binding Ligands (2009)

Getting an “A”: A label-free adenosine aptasensor has been designed based on adenosine-induced self-assembly of aptamer fragments. One aptamer fragment contains an abasic (AP) site, and the AP-site-binding ligands (★) are used as fluorescence probes for signal-off and signal-on responses. The aptasensor can detect adenosine with high selectivity over the other three nucleotides. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A Predictive Model for Delirium in Hospitalized Elderly Medical Patients Based on Admission Characteristics (1993)

Delirium among elderly hospitalized patients is common, and a simple predictive model based on four risk factors can be used at admission to identify elderly persons at the greatest risk.
Concurrent wire spreading, widening, and filling (2007)

Automated design tools produce layouts complying with all design rules (DRs). However, most wires are designed with minimum width, making them susceptible to random defect induced interruptions (opens). Spaces between wires are also often designed at minimum size, causing yield loss from random defect induced connections (shorts). SFF ("Spread - Fatten - Fill") is a methodology to improve layout - specifically for routing metal layers - in terms of yield loss related to opens and shorts. Additionally, a novel fill concept improves metal density uniformity. In this paper, we will explain issues that were observed and addressed in the implementation on a real layout, and present results achieved in the first experiment on silicon.
ViNO: SDN overlay to allow seamless migration across heterogeneous infrastructure (2015)

We propose ViNO (Virtual Network Overlay), an orchestration service that can be used to create arbitrary network topologies with OVS (Open vSwitch) switches and VMs. ViNO connects switches and VMs through an overlay network using VXLAN encapsulation. ViNO provisions VMs by making API calls to the underlying platform. Users specify the desired topology using an expressive Domain Specific Language that allows users to easily express commonly used network topologies while hiding the underlying complexity. An important use case for ViNO is enabling the seamless migration of Linux services across VMs in different regions with very little downtime.
The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk (2004)

These results suggest that the hOGG1 Ser326Cys polymorphism plays an important role in the risk for lung cancer and is linked to exposure to tobacco smoke.
Signal integrity management in an SoC physical design flow (2003)

Signal integrity closure is one of the key challenges in DSM (Deep- SubMicron) physical design. In this paper, we propose a physical design methodology which includes signal integrity management through noise analysis and repair at multiple phases of the design so that a quick noise convergence can be achieved. The methodology addresses both functional and delay noise problems in the design and is targeted for block, platform, and chip level physical design of SoC (System-On-Chip) designs. A number of case studies are presented to illustrate the effectiveness of the proposed methodology and to provide valuable insights useful for successful signal integrity management.
Supercritical Carbon Dioxide-Processed Dispersed Polystyrene−Clay Nanocomposites (2008)

Achieving clay dispersion and improving clay−polymer interactions are keys to producing superior nanocomposites. A supercritical CO2 (scCO2) processing method was utilized to prepare high molecular weight polystyrene (PS)/Cloisite 10A nanocomposites with significant dispersion and rheological enhancement. The effects of scCO2 processing, presence of cosolvent, and clay weight fraction on clay dispersion and polymer−clay interactions in nanocomposites were investigated. Rheology, WAXD, and TEM of the nanocomposites indicate that substantial improvements in the rheological properties of scCO2 nanocomposites are the result of increased dispersion and polymer−clay interactions. At low frequencies, the elastic plateau modulus of the scCO2-processing nanocomposites (5 wt % clay loading) is more than 40-fold higher than benchmark solution-blended samples. Our results suggest that the substantial contacting with scCO2, followed by rapid depressurization, produces a combination of disorder and dispersion of this “as-received” clay, and the presence of the cosolvent enables more intimate contact of the high molecular weight PS and clay.
SUSP1 antagonizes formation of highly SUMO2/3-conjugated species (2006)

Small ubiquitin-related modifier (SUMO) processing and deconjugation are mediated by sentrin-specific proteases/ubiquitin-like proteases (SENP/Ulps). We show that SUMO-specific protease 1 (SUSP1), a mammalian SENP/Ulp, localizes within the nucleoplasm. SUSP1 depletion within cell lines expressing enhanced green fluorescent protein (EGFP) fusions to individual SUMO paralogues caused redistribution of EGFP-SUMO2 and -SUMO3, particularly into promyelocytic leukemia (PML) bodies. Further analysis suggested that this change resulted primarily from a deficit of SUMO2/3-deconjugation activity. Under these circumstances, PML bodies became enlarged and increased in number. We did not observe a comparable redistribution of EGFP-SUMO1. We have investigated the specificity of SUSP1 using vinyl sulfone inhibitors and model substrates. We found that SUSP1 has a strong paralogue bias toward SUMO2/3 and that it acts preferentially on substrates containing three or more SUMO2/3 moieties. Together, our findings argue that SUSP1 may play a specialized role in dismantling highly conjugated SUMO2 and -3 species that is critical for PML body maintenance.
Selective Desorption of Alkanethiols in Mixed Self-Assembled Monolayers for Subsequent Oligonucleotide Attachment and DNA Hybridization (2001)

Oligonucleotides whose 5‘ ends are linked to mercaptohexyl tether groups (HS-ss-DNA) are attached onto gold regions freshly exposed by reductive desorption of the mercaptopropionic acid (MPA) in a mixed MPA/hexanethiol (HT) or MPA/mercaptohexanol (MCH) self-assembled monolayer (SAM). The size of the bare Au region was shown to be controllable by using various MPA/HT solution compositions during the fabrication of the mixed SAMs. Atomic force microscopy shows that the size of the segregated gold regions has a profound effect on the surface density and orientation of the subsequently immobilized HS-ss-DNA molecules. The DNA surface density begins to increase when the bare gold domain (12−19 nm wide, prepared by stripping MPA off a mixed SAM formed from a solution with an alkanethiol molar ratio of χMPA/χΗΤ = 1/4) approaches the size of the HS-ss-DNA (ca. 5−6 nm for a 17mer). The surface density of the HS-ss-DNA in the mixed HS-ss-DNA/HT SAM or the mixed HS-ss-DNA/MCH SAM is slightly greater than SAMs containing only the HS-ss-DNA, but the orientation of the HS-ss-DNA in the mixed SAM is more favorable for DNA hybridization. The quartz crystal microbalance (QCM) responses for the DNA hybridization at the DNA SAMs and mixed SAMs of HS-ss-DNA and alkanethiol formed using various adsorption methods were compared. The mixed HS-ss-DNA/HT formed using the new method resulted in a QCM signal amplification by almost 1 order of magnitude over SAMs containing only the HS-ss-DNA, with a much improved hybridization efficiency (ca. 96%).
Thin silicon nitride films for reduction of linewidth and proximity effects in e-beam lithography (1992)

A thin silicon nitride layer (50–300 nm), deposited on a semiconductor substrate, prior to resist deposition, greatly enhances the resist resolution during electron beam lithography. The resolution enhancement was manifested by smaller feature sizes, for a given dose and full resolution of individual array elements at higher doses than on a bare semiconductor substrate. The effect has been observed in 50–100 nm of both SAL-601 and PMMA spun onto silicon nitride coated Si and GaAs substrates. The samples were patterned with a 50 keV, 15 nm diam probe generated by a JEOL JBX-5DII system. Improved resolution was found on two types of silicon nitride film grown by chemical vapor deposition: one deposited at 800 °C on Si and the other deposited at 200 °C on GaAs. Linewidth reductions in SAL-601 of 40% at low doses and an order of magnitude at high doses were observed on silicon nitride coatings of 50–300 nm thickness. In PMMA, the resolution enhancement was less than in SAL-601, with only a 15% linewidth reduction observed at high doses (≥10 nC/cm). A reduction in proximity effects due to the presence of the nitride layer, is apparent in SAL-601, for array periods of 1 μm and less. Analysis of the results, combined with Monte Carlo simulations and electron microscopy suggests that fast secondary electrons, generated by the substrate are prevented by the silicon nitride layer from exposing the resist.
Human tumor-infiltrating lymphocytes: a marker of host response. (1985)

There is continuing interest in the possibility of immunologic intervention in the therapy of malignant disease. By employing a range of different techniques, it has been possible to show the presence of activated helper, suppressor, and cytotoxic T cells, B cells, NK precursors, and macrophages at the tumor site. The overwhelming impression from our data is that tumors may be subject to immunologic attack by heterogeneous effectors and that there is selective trapping of these effectors with corresponding depletion at the periphery. Like all inflammatory sites, however, the tumor contains both positive and negative regulatory mechanisms with the coexistence of cells with effector and suppressor functions, eg, T suppressors that modulate the proliferative response of T helpers and macrophages suppressing NK function contribute to the dynamic interplay in situ. Additional complexity is indicated by immunohistologic studies that clearly show that the stroma rather than foci of tumor cells are the site of infiltration, thereby further limiting effector function. We are now at the end of the descriptive stage of our investigations and further studies must approach the more difficult problem of modifying the host response in such a way as to alter the balance between effector and suppressor activity. A promising area of research would appear to be the use of cloned helper T cells or their products in the immunotherapy of cancer. The demonstration, by us, of selective trapping at tumor sites suggests that administration of the patients' own T cells with antitumor reactivity may serve as an efficient delivery vehicle to activate host effectors in situ. Studies in animal systems have shown the feasibility of this approach, although the failure of cultured T cells to undergo normal recirculation represents a considerable unresolved problem. Effector function by each of the tumor-infiltrating cell types described is under T cell control, and preliminary studies have already indicated the ability of helper T cells to accelerate allograft and tumor rejection. The increasing availability of gene-cloned materials with potent biologic activity opens new areas of research in cancer therapy. The lymphokines IL-2 and interferon are already undergoing clinical trials. Studies by Hersey demonstrate that administration of conditioned medium containing impure IL-2 results in the appearance of antitumor effectors in previously nonreactive melanoma patients, and Rosenberg, among others, has shown IL-2 to be a potent enhancer of alloimmune responses. Lymphokine-activating macrophages also augment antitumour responses.(ABSTRACT TRUNCATED AT 400 WORDS)
High-Resolution Scanning Transmission Electron Tomography and Elemental Analysis of Zeptogram Quantities of Heterogeneous Catalyst (2004)

The ability to visualize the three-dimensional structure of an object is of central importance in many branches of science and engineering. Recording an angular series of two-dimensional projections (images) and subsequently applying tomographic reconstruction methods has proven to be extremely successful at many lengthscales. Using scanning transmission electron microscopy (STEM) high angle annular dark field (HAADF) imaging, we describe how the three-dimensional distribution of bimetallic nanocatalysts (such as Ru10Pt2, diameter ∼1 nm, mass 10-21 g) within mesoporous hosts may be precisely determined. Moreover, the simultaneous retrieval of the elemental composition (from electron-stimulated X-ray emission spectra) of individual catalytic nanoparticles was achieved.
Profile of inhaled levodopa and its potential in the treatment of Parkinson&rsquo;s disease: evidence to date (2018)

Inhaled levodopa is a newly emerging therapeutic option in the treatment of "off " symptoms associated with Parkinson's disease (PD). Its mode of delivery offers more rapid absorption of levodopa and shorter onset of clinical benefit compared to oral formulations, and has been shown to be feasible for use in patients with PD experiencing worse motor function due to declining plasma levodopa levels. Clinical development of this compound is supported by preclinical, Phase I-III, long-term-safety studies and studies in special populations, including otherwise-healthy asthmatics and smokers. These investigations demonstrated that the drug is well tolerated without risk of long-term (up to 1 year) changes in pulmonary function or spirometry measures. The most common side effects among PD patients were a mild cough, upper respiratory tract infection, nausea, sputum discoloration, and dyskinesia. Inhaled levodopa offers a different administration method and side-effect profile from the currently available options for rescue therapy for Off periods in PD, though comparative studies have not been performed. The drug is presently under review by the US Food and Drug Administration.