gebhart/patrepeval huggingface dataset:
Cytotoxic effects of γδ T cells expanded <i>ex vivo</i> by a third generation bisphosphonate for cancer immunotherapy (2005)

Nitrogen containing-bisphosphonates (N-BPs), widely used to treat bone diseases, have direct antitumor effects via the inactivation of Ras proteins. In addition to the direct antitumor activities, N-BPs expand gammadeltaT cells, which exhibit major histocompatibility complex-unrestricted lytic activity. BPs accumulate intermediate metabolites which may be tumor antigens in target cells. The purpose of our study was to clarify the cytotoxicity of gammadelta T cells expanded ex vivo by the most potent N-BP, zoledronate (ZOL). Especially, we focused on the importance of pretreatment against target cells also with ZOL; 1 microM ZOL plus IL-2 increased the absolute number of gammadeltaT cells 298-768 fold for 14 days incubation. The small cell lung cancer and fibrosarcoma cell lines pretreated with 5 microM ZOL showed a marked increase in sensitivity to lysis by gammadeltaT cells. While, untreated cell lines were much less sensitive to lysis by gdT cells. Video microscopy clearly demonstrated that gammadeltaT cells killed target cells pre-treated with ZOL within 3 hr. Pretreatment with 80 microg/kg ZOL also significantly enhanced the antitumor activity of gammadeltaT cells in mice xenografted with SBC-5 cells. These findings show that ZOL significantly stimulated the proliferation of gammadeltaT cells and that gammadeltaT cells required pre-treatment with ZOL for cytotoxic activity against target cells.
Ethylene–Propylene Elastomers (2002)

Abstract Ethylene–propylene–diene rubbers, commonly called EPDM or EPM, continue to be one of the most widely used and fastest growing synthetic rubbers. They are particularly known for their excellent ozone and aging resistance in comparison with natural rubber and polydiene synthetic rubbers. The technology of producing EP(D)M rubber is still very much in development. Later years have seen major breakthroughs in production technologies relative to the solution and slurry processes based on Ziegler–Natta catalysis, ie, gas‐phase technology and technology based on metallocene catalysis. EPDM rubber can be extended with fillers and oil plasticizers to a very high level, leading to an attractive price/performance ratio in comparison with other rubbers. EPM can be vulcanized radically by means of peroxides; a small amount of built‐in nonconjugated diene monomer in EPDM permits conventional vulcanization with rubber. Particular emphasis is put on the different processing steps involved in the production of vulcanized EPDM articles. Typical applications of EP(D)M are in automotive weatherstrip profiles, solid and sponge, and radiator hoses; in building and construction as sealing profiles and roofing foils; in cable and wire as insulating and jacketing material; in blends with general‐purpose rubbers to improve ozone resistance; as impact modifier for thermoplastics; and as additive to lubricating oils.
Oligothiophene‐Functionalized Truxene: Star‐Shaped Compounds for Organic Field‐Effect Transistors (2005)

Abstract Organic field‐effect transistors (OFETs) based on oligothiophene‐functionalized truxene derivatives have been fabricated for use as novel star‐shaped organic semiconductors in solution‐processible organic electronics. The electronic and optical properties of compounds 1 – 3 , with increasing numbers of thiophene rings at each of the three branches, have been investigated using scanning electron microscopy (SEM), X‐ray diffraction measurements, and ultraviolet–visible (UV‐vis) and photoluminescence spectroscopies. The results show that with a stepwise increase of the thiophene rings at every branch, a transition from a polycrystalline to an amorphous state is observed. The characteristics of compounds 1 , 2 , and 3 used for OFETs exhibit a significant difference. The mobility depends greatly on the morphology in the solid state, and decreases in going from 1 to 3 . Mobilities up to 1.03 × 10 –3 cm 2 V –1 s –1 and an on/off ratio of about 10 3 for compound 1 have been achieved; these are the highest values for star‐shaped organic semiconductors used for OFETs so far. All the results demonstrate that the truxene core of the oligothiophene‐functionalized truxene derivatives not only extends the π‐delocalized system, but also leads to high mobilities for the compounds.
Dual Polarized Ku-Band Phased Array on ROHACELL utilizing Silicon Beamforming Chipsets (2019)

This paper presents a Ku-Band (10 - 15 GHz) 64- element phased array utilizing commercially available silicon beamforming chipsets. The phased array is able to scan ±30 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> in both azimuth and elevation with less than 15 dB of cross-polarization. It supports linear vertical and horizontal polarizations as well as both transmit and receive modes utilizing half duplex operation. The array has a size of 4.2" × 5.5" and consumes 12.8 W in receive and 16 W in transmit. This array is demonstrated utilizing ROHACELL foam as a spacer in order to improve bandwidth.
Selective Erasure and Nonstorage Writing in Direct-View Halftone Storage Tubes (1961)

A new type of direct-view halftone storage tube that can selectively erase as well as simultaneously display stored and nonstored information has been developed. Heretofore, incorporation of these features into direct-view halftone storage tubes has proved impractical because of the nature of the secondary-emission effect on which the writing and erasing of stored information depend. In this new tube, this limitation is overcome by the use of a dual-effects target. One effect, secondary emission, charges the storage surface positively, while the other, bombardment-induced conductivity, charges it toward the backing-electrode potential, wihch in this case is negative. Selection of the effect and, consequently, the charging direction, is determined by the incident beam energy. At low energies secondary emission predominates and the target is written on, i.e., charged positively. At high energies, the bombardment-induced conductivity prevails and the target is erased, i.e., the positively charged areas are discharged. The two effects cancel at an appropriate intermediate beam energy, thus permitting presentation of nonstored information without otherwise disturbing the display, by means of that portion of the beam current which passes through the backing electrode and strikes the viewing screen. A 5-inch, direct-view halftone storage tube that utilizes such a dual-effects target is described. At writing speeds between 10,000 and 15,000 inches per second, the stored resolution is 40 to 50 lines per inch. At erase speeds between 30,000 and 40,000 inches per second, the stored resolution is 100 to 120 lines per inch.
Intra prediction mode based improved deblocking filter (2011)

In this paper, an improved deblocking filter for intra blocks is proposed. By applying different strength of deblocking filter adaptively to intra blocks based on intra prediction mode, the proposed method not only improves visual quality but also achieves coding performance.
Blue to type 2 binding. Copper(II) and cobalt(II) derivatives of a Cys112Asp mutant of Pseudomonas aeruginosa azurin (1992)

Of the five invariant residues that surround the copper in azurins, the ligand cysteine at position 112 (Cys112) is believed to be especially important in the bonding interactions responsible for the unusual blue copper absorption and electron paramagnetic resonance (EPR) spectra. It is striking that mutagenesis studies of Met121, His46, and His174 ave shown that these ligands are not required for a blue copper center, thereby reinforcing the feeling that Cys112 is absolutely essential. To address this issue directly, we have replaced Cys112 with Asp by site-directed mutagenesis.
Group V Secretory Phospholipase A2 Is Involved in Macrophage Activation and Is Sufficient for Macrophage Effector Functions in Allergic Pulmonary Inflammation (2013)

We reported that Pla2g5-null mice lacking group V secretory phospholipase A2 (gV-sPLA2) showed reduced eosinophilic pulmonary inflammation and Th2 cytokine generation when challenged with an extract from house dust mite Dermatophagoides farinae, compared with wild-type (WT) controls. Adoptive transfer studies suggested that gV-sPLA2 in dendritic cells was necessary for sensitization of Pla2g5-null mice, but was not sufficient to induce the effector phase of pulmonary inflammation. In this study, we demonstrate that gV-sPLA2 is inducibly expressed in mouse and human macrophages (M) activated by IL-4 and is required for the acquisition of M effector functions that facilitate the effector phase of pulmonary inflammation. We demonstrate that gV-sPLA2 expression in M is sufficient for the development of pulmonary inflammation, even when inflammation is induced by intrapulmonary administration of IL-4. The concentrations of CCL22/CCL17 and effector T cell recruitment are severely impaired in Pla2g5-null mice. Intratracheal transfers of enriched CD68(+) cells isolated from the lungs of D. farinae-challenged WT donor mice induce eosinophilia, chemokine production, and recruitment of T cells into the lungs of Pla2g5-null recipients previously sensitized by WT D. farinae-loaded dendritic cells. Our studies identified a unique function of gV-sPLA2 in activation of M and in their capacity to recruit T cells to amplify the effector phase of pulmonary inflammation.
Synthesis of Tetra-3-butenyl-Substituted Metallocenes and the Application of 1,1‘,3,3‘-Tetrakis(1,1-dimethyl-3-butenyl)ferrocene as Core for the Preparation of Polynuclear Compounds (2000)

The synthesis of the 1,1‘,3,3‘-tetrabutenyl-substituted metallocenes [C5H3(CMe2CH2CHCH2)2]2M (M = Fe 1, Co 2, Ni 3), their electrochemical properties, and the solid-state structures of 1 and 3 are presented. Hydrosilylation of 1 with dimethylphenylsilane leads to [C5H3(CMe2(CH2)3SiMe2Ph)2]2Fe, 4. The π-coordination ability of the arene system in 4 has allowed the preparation of the pentanuclear complex [C5H3(CMe2(CH2)3SiMe2(η6-C6H5−Cr(CO)3)2]2Fe, 5, containing a ferrocene core and peripherial η6-coordinated Cr(CO)3 moieties. Electrochemical investigations of 5 show a reversible oxidation of the ferrocene unit as well as an independent, noninteracting irreversible oxidation of the Cr centers.
Gradient force: The mechanism for surface relief grating formation in azobenzene functionalized polymers (1998)

A model for the formation of holographic surface relief gratings in azobenzene functionalized polymers is presented. Forces leading to migration of polymer chains upon exposure to light in the absorption band of the azo chromophore are attributed to dipoles interacting with the gradient of the electric field present in the polymer material. Efficient trans–cis cycling in the azobenzenes allows cooperative movement of the chromophores under the influence of gradient forces.
Space Event Detection Method (2008)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets (2010)

BCR-ABL negative myeloproliferative neoplasms (MPNs; polycythemia vera, essential thrombocythemia, primary myelofibrosis) are malignant diseases arising from a multipotent hematopoietic progenitor, frequently altered by JAK2 V617F or other JAK/STAT activating mutations. The thrombopoietin receptor (TpoR, MPL) is one of the major dimeric cytokine receptors that use JAK2 in the myeloid lineage, and was found to be down-modulated in certain MPN patients. We searched for negative regulators of MPL expression. Here we report that miR-28 targets the 3' untranslated (3'UTR) region of MPL, inhibiting its translation, as well as other proteins potentially involved in megakaryocyte differentiation, such as E2F6. Expression of miR-28 in CD34-derived megakaryocytes inhibited terminal differentiation. miR-28 was found to be overexpressed in platelets of a fraction of MPN patients, while it was expressed at constant low levels in platelets from healthy subjects. Constitutive activation of STAT5 leading to autonomous growth of hematopoietic cell lines was associated with increased miR-28 expression. We discuss how down-modulating MPL and other targets of miR-28, and of related miR-708 and miR-151, could contribute to MPN pathogenicity.
Rapid isothermal processing of strained GeSi layers (1992)

A cold-wall rapid thermal processor was used to study the oxidation and annealing properties of Ge/sub x/Si/sub 1-x/ strained layers. The dry oxidation rate of Ge/sub x/Si/sub 1-x/ was found to be the same as that of Si, while the wet oxidation rate was found to be higher than that of Si, and the oxidation rate increases with the Ge concentration (up to 20% in this study). A high fixed oxide charge density (>5*10/sup 11//cm/sup 2/) and interface trap level density (>10/sup 12//cm/sup 2/-eV) at the oxide interface have been determined from capacitance-voltage measurements. Using techniques such as X-ray rocking curve analysis and I-V and C-V measurements of the p-n heterojunction it was found that the degradation of electronic properties of metastable Ge/sub x/Si/sub 1-x/ strained layers during rapid thermal annealing are related to the formation of structural defects at the heterointerfaces.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Administration to mice of a monoclonal antibody that neutralizes the intracellular mature virus form of vaccinia virus limits virus replication efficiently under prophylactic and therapeutic conditions (2002)

The WHO smallpox eradication program was concluded 21 years ago and the non-vaccinated population is now at risk of poxvirus infections, either by contact with monkeypox or through bioterrorism. Since drugs specific against poxvirus infections are limited, neutralizing monoclonal antibodies (mAbs) that are effective in vivo may be an important tool in controlling poxvirus infections. To this end, we studied the efficacy of the mAb C3, reactive against the trimeric 14-kDa protein of vaccinia virus (VV) localized in the membrane of the intracellular form of mature virus, for its ability to neutralize VV infection in mice. The results show that prophylactic as well as therapeutic administration of mAb C3 can be an effective means of control of VV replication within the host. The interval of antibody efficacy following a single administration, before and after VV inoculation, has been defined. This study reinforces the notion that neutralizing mAbs should be developed to control health-related human infections by poxviruses.
Effects of Cycle-Aging on Magnetic Properties of Sm(Co, Fe, Cu, Ni, Zr)<SUB>7.6</SUB> Magnets (1987)

It is now well established that the addition of Zr and/or Hf increases the coercive force of the Sm2Co17 type magnets. The coercive force of this type magnets is due to the domain wall pinning mechanism, and it is industrially important to improve the squareness of the hysteresis loop in order to minimize the magnetizing field. In this study, influences of aging treatments of Sm(Co0.67Fe0.21Cu0.08Ni0.02Zr0.02)7.6 magnets were investigated with regard to the coercive force and the shape of the hysteresis loop. Results obtained are as follows; the continuous cooling, which is well known as a standard aging treatment for producing a high coercive force in the Sm2Co17 type magnets, increases the intrinsic coercive force, as the starting temperature of continuous cooling is raised in the range of 1103-1173 K. However, the squareness of the hysteresis loop becomes poorer, if the intrinsic coercive force of magnets was increased to a higher value than 520 kA·m−1 by this treatment. On the contrary, we found that a repeated continuous cooling from lower starting temperatures (i.e. 1053-1073 K) induced a high coercive force in this material with a good square hysteresis loop making it easier to be magnetized. For instance, a magnet which possesses an intrinsic coercive force of 820 kA·m−1 and a maximum energy product of 223 kJ·m−3 can be obtained by three cycles of continuous cooling from 1053 K, and it can be magnetized almost fully with a field less than 1600 kA·m−1. We also observed that a cycle-aged magnet has a finer two-phase structure consisting of the 2-17 phase and the 1-5 phase as compared with a single-aged magnet of about the same intrinsic coercive force.
REUNIÓN DE ORGANIZACIÓN Y GOBIERNO DE LA PREPARATORIA (2007)

AL PONERSE EN MARCHA LA XXI REUNION DE ORGANIZACION GOBIERNO DE LA ESCUELA NACIONAL PREPARATORIA (ENP) CON EL OBJETIVO DE FORTALECER EL BACHILLERATO, SU DIRECTORA, MARIA DE LOURDES S NCHEZ OBREGON, ASEGURO QUE EL MOMENTO ACTUAL DE ESA ESCUELA ES INEDITO POR LAS EXCELENTES CONDICIONES EN QUE SE ENCUENTRA, POR ELLO CONFIO EN QUE SIGA SIENDO LIDER EL MEJOR BACHILLERATO EN EL NIVEL MEDIO SUPERIOR. DURANTE LA REUNION, INAUGURADA POR EL RECTOR JUAN RAMON DE LA FUENTE, INFORMO SOBRE LA SITUACION ACTUAL LOS LOGROS DE LA ENP. SOSTUVO QUE NO SOLO LOS HAY HACIA EL EXTERIOR, SINO TAMBIEN EN FORMA COTIDIANA: EN LAS AULAS, LOS LABORATORIOS LOS CAMPOS DEPORTIVOS. MARIA DE LOURDES S NCHEZ HABLO ANTE LOS SECRETARIOS GENERAL, ENRIQUE DEL VAL; DE DESARROLLO INSTITUCIONAL, ROSAURA RUIZ, DE SERVICIOS A LA COMUNIDAD, JOSE ANTONIO VELA; LA COORDINADORA DEL CONSEJO ACADEMICO DEL BACHILLERATO, LIDIA ORTEGA, LOS DIRECTORES DE LOS NUEVE PLANTELES QUE INTEGRAN LA PREPARATORIA. AHI, EXPLICO QUE SE HA CONJUNTADO EL MEJORAMIENTO DE LA INFRAESTRUCTURA SE CUENTA CON EL HILO CONDUCTOR DEL LIBRO CONOCIMIENTOS FUNDAMENTALES PARA LA ENSENANZA MEDIA SUPERIOR, QUE PERMITIR N CUMPLIR CON LAS EXPECTATIVAS QUE LAS FACULTADES TIENEN DEL BACHILLERATO. COMO CONSECUENCIA, ARGUMENTO, LA FORMACION ACADEMICA DE LOS PROFESORES SER  EN LA MISMA LINEA DE ACUERDO CON LAS NECESIDADES DE ESTE SISTEMA. A ELLO SE SUMA EL HECHO DE QUE LOS ALUMNOS QUE CARECEN DE RECURSOS ECONOMICOS SUFICIENTES PARA CONTINUAR SUS ESTUDIOS, AHORA RESULTAR N FAVORECIDOS CON LAS BECAS. DIJO QUE SE HAN LOGRADO LUGARES RELEVANTES EN CONCURSOS NACIONALES E IBEROAMERICANOS COMO VEAMOS LA CIENCIA PARA LA OLIMPIADA. POR OTRA PARTE, TAMBIEN SE HA REBASADO EL INDICE DE EGRESO; LOS INDICADORES SENALAN QUE HA AUMENTADO ENTRE DOS TRES POR CIENTO. EN MATERIA DE DEPORTE, LA SUPERACION HA SIDO ANUAL. LA ENP SIEMPRE EST  POR ARRIBA DE 50 POR CIENTO RESPECTO DE LAS MEDALLAS QUE GANA LA UNIVERSIDAD EN SU CONJUNTO. SE CUENTA CON EXCELENTES ESTUDIANTES BUENAS INSTALACIONES, AHORA LO QUE FALTA ES MEJOR ENTRENAMIENTO SUPERARNOS M S. MARIA DE LOURDES S NCHEZ DETALLO QUE EN ESTA REUNION, REALIZADA DEL 2 AL 4 DE JULIO, SE ANALIZARON LOS ASPECTOS VITALES. LOS DIRECTORES DE LOS NUEVE PLANTELES DISENARON UN PROGRAMA PARA EL MEJORAMIENTO DEL APRENDIZAJE EN MATEM TICAS. LOS JEFES DE DEPARTAMENTO TRABAJARON EN EL RUBRO EDUCATIVO CON LA ELABORACION DE UN EXAMEN DIAGNOSTICO PARA CUARTO QUINTO ANOS. SE BUSCO CONOCER EL AVANCE DE ENSENANZA-APRENDIZAJE. DE EDUCACION ESTETICA ARTISTICA, DIJO QUE SE REQUIERE SIMPLIFICAR EL  REA ADMINISTRATIVA PARA UNA MEJOR ENSENANZA, PORQUE LOS ALUMNOS DEBEN CONCLUIR EL BACHILLERATO CON UNA FORMACION INTEGRAL, INCLUIDO EL ARTE. DURANTE SU INTERVENCION, EL RECTOR DE LA FUENTE RESALTO QUE LA NACIONAL PREPARATORIA ES UN COMPONENTE INDISOLUBLE DE LA UNIVERSIDAD. LA ENP, PRECISO, LE DA LUSTRE A LA INSTITUCION, Y NOS HACE SENTIR A TODOS LOS UNIVERSITARIOS ORGULLOSOS DE ELLA, DE SUS MAESTROS, EGRESADOS ALUMNOS, ASI COMO DE LA FORMA EN QUE ANTICIPAN EL FUTURO CON TRABAJO, DEDICACION, INTELIGENCIA  NIMO IRREDUCTIBLE, QUE CARACTERIZA A TODA LA COMUNIDAD.
A Virtual Reality Surgical Trainer for Navigation in Laparoscopic Surgery (2001)

A virtual reality trainer was designed to familiarize students and surgeons with surgical navigation using an angled laparoscopic lens and camera system. Previous laparoscopic trainers have been devoted to task or procedure training. Our system is exclusively devoted to laparoscope manipulation and navigation. Laparoscopic experts scored better than novices in this system suggesting construct validity. The trainer received favorable subjective ratings. This simulator may provide for improved navigation in the operating room and become a useful tool for residents and practicing surgeons.
Efficient disc on pillar substrates for surface enhanced Raman spectroscopy (2011)

In this work, geometrical optimizations of Ag disc on pillar (DOP) hybrid plasmonic nanostructures were conducted and allowed us to achieve reproducible average enhancement factors of 1 × 10(9) and greater.
FMR1 RNA within the Intranuclear Inclusions of Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) (2004)

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a recently identified neurodegenerative disorder affecting older adult males with premutation alleles of the fragile X mental retardation 1 (FMR1) gene. The principal clinical features of FXTAS include progressive intention tremor, gait ataxia, parkinsonism, and autonomic dysfunction. The disorder affects at least one-third of carrier males over 50 years of age and, with an estimated carrier frequency of approximately 1/800 males, is likely to be one of the most common heritable forms of tremor and ataxia among older adult males in the general population. Brains from all FXTAS cases examined to date (10/10) possess numerous ubiquitin-positive intranuclear inclusions in broad distribution throughout the cerebrum and brainstem. The absence of either the neurodegenerative disorder or inclusions among adults with fragile X syndrome (who lack the FMR1 protein), coupled with elevated FMR1 mRNA with expanded CGG repeats in premutation carriers, has led us to propose an RNA toxic gain-of-function model for FXTAS. Consistent with this model, we have now identified FMR1 mRNA within the intranuclear inclusions isolated from post-mortem (FXTAS) brain tissue.
Source for ultrafast continuum infrared and terahertz radiation (2010)

A compact and stable method for generating high-intensity linearly polarized continuum mid-IR and terahertz light using ultrafast femtosecond (fs) laser pulses is demonstrated. Continuous light generation from <400 cm(-1) (12 THz, 25 microm) to >3300 cm(-1) (100 THz, 3 microm) in a sub-100 fs laser pulse is facilitated by nonlinear mixing of the fundamental, second harmonic, and third harmonic of an ultrafast amplified laser source through filamentation in air. Including the third harmonic in the mixing scheme leads to a tenfold increase in the generated IR power. The compact optical configuration utilizing a delay plate in a collinear geometry serves to simplify alignment and increase stability, making it a practical source for transient IR spectroscopy.
Optical photometric observations of the Be/X-ray binary (2008)

Optical observations of the transient Be/X-ray binary V0332+53 (ATel #1792), was carried out using 1-m Sampurnanand telescope at ARIES, Nainital. We observed the field in UBVRI bands for 4 hours since 19.287 hrs UT on 2008-10-21. To calibrate the photometry, we also observed the SA95 and PG2213 Landolt (1992) standard fields during the same night. The transient source magnitudes during our observations are U=17.49+/-0.02, B=17.17±0.01, V=15.41±0.01, R = 14.23±0.01 and I=13.04±0.01.