gebhart/patrepeval huggingface dataset:
Improving fuel economy and robustness of an improved ECMS method (2013)

Hybrid electric vehicles have shown significant improvement for both fuel efficiency and emission reduction, and attracted many researchers. Paramount for the fuel efficiency of HEVs is the energy management control strategies. ECMS (equivalent consumption minimization strategy) is one of the well-known real time power management strategies and has been used extensively in different works; however, its intrinsic difficulty is to find the optimal equivalent factor, which in theory is determined by the a priori knowledge of the complete driving cycle. Different methods have been proposed to solve this issue, but each one has its own pros. and cons. Especially, the applicability of each method for different cycles as well as the computation overhead are two main concerns in the methods presented so far. In this paper, a new method is presented for calculating equivalent factor in the ECMS method. The method does not rely on any prediction nor the a priori knowledge of driving cycles. Its robustness is demonstrated through different driving cycles with distinct characteristics. Our new method will improve the effectiveness and robustness of the ECMS method.
Reversion of Somatic Mutations of the Respiratory Syncytial Virus–Specific Human Monoclonal Antibody Fab19 Reveal a Direct Relationship between Association Rate and Neutralizing Potency (2013)

The role of affinity in determining neutralizing potency of mAbs directed against viruses is not well understood. We investigated the kinetic, structural, and functional advantage conferred by individual naturally occurring somatic mutations in the Ab H chain V region of Fab19, a well-described neutralizing human mAb directed to respiratory syncytial virus. Comparison of the affinity-matured Ab Fab19 with recombinant Fab19 Abs that were variants containing reverted amino acids from the inferred unmutated ancestor sequence revealed the molecular basis for affinity maturation of this Ab. Enhanced binding was achieved through mutations in the third H chain CDR (HCDR3) that conferred a markedly faster on-rate and a desirable increase in antiviral neutralizing activity. In contrast, most somatic mutations in the HCDR1 and HCDR2 regions did not significantly enhance Ag binding or antiviral activity. We observed a direct relationship between the measured association rate (Kon) for F protein and antiviral activity. Modeling studies of the structure of the Ag-Ab complex suggested the HCDR3 loop interacts with the antigenic site A surface loop of the respiratory syncytial virus F protein, previously shown to contain the epitope for this Ab by experimentation. These studies define a direct relationship of affinity and neutralizing activity for a viral glycoprotein-specific human mAb.
Fas- and tumor necrosis factor receptor 1-dependent but not perforin-dependent pathways cause injury in livers infected with an adenovirus construct in mice (2000)

Intravenous injection of type 5 adenovirus, deleted in the E1 and E3 regions, is shown to result in expression of viral antigens in the liver, initiating lymphocyte infiltration and liver injury. Following this infection, induction of Fas ligand (FasL), tumor necrosis factor alpha (TNF-alpha), and perforin mRNA are all demonstrable in the liver, pointing to a role of respective pathways in liver injury. Making use of mice in which the genes coding for Fas, FasL, TNF receptors (TNFRs), and perforin are inactivated, as well as recombinant proteins that inhibit Fas- and TNF-alpha-mediated apoptosis, it is shown that a functional perforin-mediated mechanism is not obligatory for cellular infiltration and progression of liver injury. In contrast functional Fas- and TNF-alpha-mediated mechanisms were found to be essential for liver injury to occur. Results are presented demonstrating that signaling through TNFR1, but not TNFR2, is involved in TNF-alpha-mediated liver damage. The conclusion is drawn that although perforin mRNA is induced in the virus-infected liver, Fas- and TNF-alpha-mediated mechanisms constitute the principal pathways by which the cell-mediated immune system causes acute liver injury.
Fully activated Li2MnO3 nanoparticles by oxidation reaction (2012)

Fully activated Li2MnO3 nanoparticles were prepared by a chemical based oxidation reaction. All of the diffraction peaks of the prepared samples were well matched to a monoclinic phase (space group: C2/m) with no impurity peaks and refined using the General Structure Analysis System (GSAS) program. The activated Li2MnO3 sample showed homogeneously well-dispersed nanoparticles with a size of ∼10 nm. The oxidation state of Mn was confirmed by XPS. The activated Li2MnO3 nanoparticles delivered a high charge capacity of 302 mA h g−1 above 4.5 V and discharge capacity of 236 mA h g−1 during the first cycle. Interestingly, the cycle performance of the activated Li2MnO3 nanoparticles during extended cycles exhibited somewhat stable discharge capacities without any drastic capacity fading, even when cycled in the high voltage range of 2.0–4.9 V and after the phase transition to spinel. In terms of the rate performance, the activated Li2MnO3 sample exhibited significantly superior properties compared to the bulk Li2MnO3 sample, probably due to the nano-size particles with high crystallinity.
Automated Trimming of Composite Panels (1986)

Developpement d'un systeme automatique permettant un ebarbage net des pieces composites pour l'industrie aerospatiale
Social science and a post-genomic future: alternative readings of genomic agency (2005)

This paper explores competing discourses that envision different socio-technical landscapes opened up by the completion of the map of the human genome in 2003. It examines the ways in which the map, and it organising principle and very rationale--the gene as the sole or prime agent through which to understand the body and its disordering (as disease)--has been interpreted in quite distinct ways. It suggests how the sequences of a genomic map have post-genomic con-sequences that depend on a social rather than simply biological reading of genomic agency. Various accounts of the map and genetic agency or [sic] described, within science, science policy and social science, especially across science and technology studies (STS). The paper concludes with a comparative summary of these positions and asks whether a deconstructive reading of genomic agency by STS analysts might be the basis for a critical re-constructive engagement with post-genomic policy discourse that avoids the over-determination of agency one often finds in the latter.
An Asian Indian Woman with Wolfram Syndrome on Insulin Pump: Successful Pregnancy and Beyond (2011)

Wolfram syndrome (WS), or DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness), is a rare autosomal recessive neurodegenerative disorder with a median life expectancy of 30 years and occurs in one in 770,000 live births. To date only five successful pregnancies have been reported among WS subjects worldwide. Here we describe the sixth report of successful pregnancy in a WS patient and the first from India. The subject is still on an insulin pump, now 31 years old and doing well. She developed diabetes at 5 years of age, optic atrophy at 14 years, and diabetes insipidus at 25 years and had a successful delivery in 2007 while on an insulin pump. Sequencing of exonic regions of the WFS1 gene showed five changes, two of which were pathogenic (exon 8). Magnetic resonance imaging of brain showed generalized neurodegenerative changes. The benefits of continuous subcutaneous insulin infusion and that of tight metabolic control in prevention of abortions and fetal malformations in diabetes associated with pregnancy are well documented. The impression of probable pleiotropic action of insulin pumps over and above that of glycemic reduction is gaining momentum. Recent evidence supports use of insulin pumps in alleviating neuropathic pain in diabetes, probably by virtue of its action in minimizing mean amplitude of glycemic excursions not possible with conventional insulin shots. WS is a progressive neurodegenerative disorder, which will probably help us in understanding the positive impact of continuous subcutaneous insulin infusion in prolonging the life span and retarding neuronal damage in WS.
Deodorizing Mechanism of (–)-Epigallocatechin Gallate against Methyl Mercaptan (1995)

Journal Article Deodorizing Mechanism of (–)-Epigallocatechin Gallate against Methyl Mercaptan Get access Hideyuki Yasuda, Hideyuki Yasuda Lotte Central Laboratory Co., Ltd., 3–1–1 Numakage, Urawa, Saitama 336, Japan Search for other works by this author on: Oxford Academic Google Scholar Tsutomu Arakawa Tsutomu Arakawa Lotte Central Laboratory Co., Ltd., 3–1–1 Numakage, Urawa, Saitama 336, Japan Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 59, Issue 7, 1 January 1995, Pages 1232–1236, https://doi.org/10.1271/bbb.59.1232 Published: 01 January 1995 Article history Received: 25 November 1994 Published: 01 January 1995
The selection of water property formulae for volume and flow calibration (2008)

Equation (10) in this paper contains two errors. Incorrect summation boundaries and referenced constants were quoted, and the first constant had the negative sign omitted. The corrected equation is . where t is the temperature (°C) and the constants are given below: .
Relaxion measure problem (2018)

We examine the necessity of requiring that relaxion dynamics is dominated by classical slow roll and not quantum fluctuations. It has been recently proposed by Nelson and Prescod-Weinstein [Phys. Rev. D 96, 113007 (2017)] that abandoning this requirement can lead to a unified solution of the hierarchy and strong $CP$ problems in QCD relaxion models. In more general models this results in a higher value of the allowed cutoff. In this work we find, however, that relaxing this condition can result in the Universe being dominated in physical volume by regions arising from large quantum fluctuations of the relaxion. These regions turn out to be problematic for the relaxion mechanism because either the relaxion does not stabilize at all or it stabilizes at vacua which cannot reproduce the observed properties of our Universe. The size of these undesirable regions is moreover ambiguous because of the measure problem. For instance, we show that if one chooses to use the scale-factor cutoff measure such dangerous regions occupy a negligible volume and these issues do not arise.
Creatine supplementation and swim performance: a brief review. (2006)

Nutritional supplements are popular among athletes participating in a wide variety of sports. Creatine is one of the most commonly used dietary supplements, as it has been shown to be beneficial in improving performance during repeated bouts of high-intensity anaerobic activity. This review examines the specific effects of creatine supplementation on swimming performance, and considers the effects of creatine supplementation on various measures of power development in this population. Research performed on the effect of creatine supplementation on swimming performance indicates that whilst creatine supplementation is ineffective in improving performance during a single sprint swim, dietary creatine supplementation may benefit repeated interval swim set performance. Considering the relationship between sprint swimming performance and measurements of power, the effect of creatine supplementation on power development in swimmers has also been examined. When measured on a swim bench ergometer, power development does show some improvement following a creatine supplementation regime. How this improvement in power output transfers to performance in the pool is uncertain. Although some evidence exists to suggest a gender effect on the performance improvements seen in swimmers following creatine supplementation, the majority of research indicates that male and female swimmers respond equally to supplementation. A major limitation to previous research is the lack of consideration given to the possible stroke dependant effect of creatine supplementation on swimming performance. The majority of the research conducted to date has involved examination of the freestyle swimming stroke only. The potential for performance improvements in the breaststroke and butterfly swimming strokes is discussed, with regards to the biomechanical differences and differences in efficiency between these strokes and freestyle. Key PointsCreatine supplementation does not improve single sprint swimming performance.Creatine supplementation does improve repeated interval swim set performance.Creatine supplementation does improve power development in swimmers when measured on a swim bench ergometer.As a result of the high energy demands of the butterfly and breaststroke competitive swimming styles, potentially, the benefits associated with creatine supplementation and swimming performance could be greater when swimming butterfly or breaststroke, compared to the commonly examined freestyle swimming stroke.
Ultrastructure of bovine blastocysts following cryopreservation: Effect of method of blastocyst production (2000)

The objective of this study was to describe the ultrastructure of blastocysts derived by in vivo and in vitro methods and to investigate how the morphology is affected by exposure to cryoprotectant (10% glycerol) or cryopreservation by conventional slow freezing. In vivo derived blastocysts were characterized by a narrow perivitelline space (PvS), a continuous cover of numerous stacked microvilli (MV) on the plasma membrane, a well-defined system of cell-to-cell coupling and a large population of round or elongated mitochondria with numerous transverse cristae. Exposure of these blastocysts to cryoprotectant was manifested by shrinkage of the blastocysts and swelling of the mitochondria. Cryopreservation resulted in further shrinkage, damage to the MV, and accumulation of cellular debris. In comparison, the in vitro matured (IVM)/in vitro fertilized (IVF) in vivo cultured blastocysts displayed a wider PvS; they appeared to possess less MV and all blastocysts displayed some cellular debris in their PvS. There was also a decrease in the number of junctional contacts between the trophoblastic cells. The reaction of these blastocysts to exposure to cryoprotectant was similar to that of the in vivo derived blastocysts. However, they appeared to be more susceptible to cryopreservation. The totally in vitro produced (IVP) blastocysts displayed a wider PvS, no stacking of the MV, increased numbers of lipid droplets and a further reduction in the junctional contacts between trophoblastic cells. The IVP blastocysts sustained breakage of the zona pellucida on exposure to cryoprotectant and were extremely sensitive to cryopreservation, losing all cell structure and organization. The findings of the present study indicate that in vivo derived blastocysts possess certain structural characteristics that confer a greater tolerance on them to exposure to cryoprotectant and cryopreservation.
Structure-Based Engineering of a Minimal Porin Reveals Loop-Independent Channel Closure (2014)

Porins, like outer membrane protein G (OmpG) of Escherichia coli, are ideal templates among ion channels for protein and chemical engineering because of their robustness and simple architecture. OmpG shows fast transitions between open and closed states, which were attributed to loop 6 (L6). As flickering limits single-channel-based applications, we pruned L6 by either 8 or 12 amino acids. While the open probabilities of both L6 variants resemble that of native OmpG, their gating frequencies were reduced by 63 and 81%, respectively. Using the 3.2 Å structure of the shorter L6 variant in the open state, we engineered a minimal porin (220 amino acids), where all remaining extramembranous loops were truncated. Unexpectedly, this minimized porin still exhibited gating, but it was 5-fold less frequent than in OmpG. The residual gating of the minimal pore is hence independent of L6 rearrangements and involves narrowing of the ion conductance pathway most probably driven by global stretching-flexing deformations of the membrane-embedded β-barrel.
Infectious diseases surveillance update (2001)

mosquitoes due to a long rainy season. An increase in the non-immune population and in the proportion of cases due to P falciparum (a common development when control programmes deteriorate), chloroquine resistance by P falciparum parasites, and an improvement in diagnosis resources, could also contribute to the rise in cases seen over the years. The northeastern periphery of Panama city, where the majority of the population are children, is threatened with an epidemic of haemorrhagic fever. A report on August 3 acknowledged more than 200 cases of classical dengue fever and the detection of dengue virus serotype 2. Jack Woodall (ProMED) says, “the danger here is that a child who has had type 1 more than a year ago (the case for many children in Panama), and then gets infected with type 2, 3, or 4, runs a greater risk of coming down with haemorrhagic fever.”
Near-Duplicate Image Detection System Using Coarse-to-Fine Matching Scheme Based on Global and Local CNN Features (2020)

Due to the great success of convolutional neural networks (CNNs) in the area of computer vision, the existing methods tend to match the global or local CNN features between images for near-duplicate image detection. However, global CNN features are not robust enough to combat background clutter and partial occlusion, while local CNN features lead to high computational complexity in the step of feature matching. To achieve high efficiency while maintaining good accuracy, we propose a coarse-to-fine feature matching scheme using both global and local CNN features for real-time near-duplicate image detection. In the coarse matching stage, we implement the sum-pooling operation on convolutional feature maps (CFMs) to generate the global CNN features, and match these global CNN features between a given query image and database images to efficiently filter most of irrelevant images of the query. In the fine matching stage, the local CNN features are extracted by using maximum values of the CFMs and the saliency map generated by the graph-based visual saliency detection (GBVS) algorithm. These local CNN features are then matched between images to detect the near-duplicate versions of the query. Experimental results demonstrate that our proposed method not only achieves a real-time detection, but also provides higher accuracy than the state-of-the-art methods.
Evaluating a Spoken Dialogue System that Detects and Adapts to User Affective States (2014)

We present an evaluation of a spoken dialogue system that detects and adapts to user disengagement and uncertainty in real-time.We compare this version of our system to a version that adapts to only user disengagement, and to a version that ignores user disengagement and uncertainty entirely.We find a significant increase in task success when comparing both affectadaptive versions of our system to our nonadaptive baseline, but only for male users.
A New Hypervalent Iodine Precursor of a Highly Strained Cyclic Alkyne. Generation and Trapping Reactions of Bicyclo[2.2.1]hept-2-en-5-yne (1999)

ADVERTISEMENT RETURN TO ISSUECommunicationNEXTA New Hypervalent Iodine Precursor of a Highly Strained Cyclic Alkyne. Generation and Trapping Reactions of Bicyclo[2.2.1]hept-2-en-5-yneTsugio Kitamura, Masashi Kotani, Takanobu Yokoyama, Yuzo Fujiwara, and Kenzi HoriView Author Information Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Hakozaki, Fukuoka 812-8581, Japan Department of Applied Chemistry and Chemical Engineering, Yamaguchi University, Tokiwadai, Ube, 755-8611, Japan Cite this: J. Org. Chem. 1999, 64, 3, 680–681Publication Date (Web):January 20, 1999Publication History Received28 September 1998Published online20 January 1999Published inissue 1 February 1999https://pubs.acs.org/doi/10.1021/jo9819483https://doi.org/10.1021/jo9819483rapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views818Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Energy,Hydrocarbons,Iodine,Molecular structure,Precursors Get e-Alerts
Single-strand interruptions in replicating chromosomes cause double-strand breaks (2001)

Replication-dependent chromosomal breakage suggests that replication forks occasionally run into nicks in template DNA and collapse, generating double-strand ends. To model replication fork collapse in vivo, I constructed phage lambda chromosomes carrying the nicking site of M13 bacteriophage and infected with these substrates Escherichia coli cells, producing M13 nicking enzyme. I detected double-strand breaks at the nicking sites in lambda DNA purified from these cells. The double-strand breakage depends on (i) the presence of the nicking site; (ii) the production of the nicking enzyme; and (iii) replication of the nick-containing chromosome. Replication fork collapse at nicks in template DNA explains diverse phenomena, including eukaryotic cell killing by DNA topoisomerase inhibitors and inviability of recombination-deficient vertebrate cell lines.
Plasma C-Reactive Protein in Haemodialysis (1999)

In recent years, acute phase reactants have been reevaluated as not merely biochemical markers of inflammation but also as active modulators of the inflammatory response. C-reactive protein - which is normally present in serum in only trace amounts, but whose concentration may rise markedly with inflammatory stimuli - was the first human acute phase protein discovered. It is now clear that cytokines are the major mediators of acute phase protein induction: interleukin-6 currently is felt to be the principal cytokine influencing C-reactive protein acute changes. Several studies have provided convincing evidence that among normal men, base-line serum levels of C-reactive protein are predictive of future myocardial infarction and ischemic stroke. The relevance of acute phase reactants in morbidity and mortality of haemodialysis patients has not been fully elucidated until now: in fact a few studies have implicated C-reactive protein in malnutrition, EPO-resistance, as a cardiovascular risk factor and as a marker of chronic stimulation in haemodialysis. The authors suggest the hypothesis of the occurrence of long-term complications in patients exposed to contaminated dialysate and suggest that back-filtration may induce a chronic, slowly developing inflammatory state that may be abrogated by avoiding backfiltration of contaminated dialysate.