gebhart/patrepeval huggingface dataset:
Communication Link Switching Method Based on Destination IP Address for Power Savings (2016)

As the number of Internet users increases, network devices are required to achieve power savings. For this purpose, the authors proposed a Gigabit Ethernet link rate switching method based on the destination IP address for typical networks in small offices or at home. However, this method has a problem in that the communication is interrupted for a few seconds when the link rate is switched. To solve the problem, this paper proposes a communication link switching method. In this method, a client is assumed to connect via multiple network interfaces such as Gigabit Ethernet and a wireless LAN to the user's subnet. When a user starts communicating, the method selects one of the interfaces based on the destination IP address. The communication experiments demonstrate that the proposed method has improved power consumption and avoided any communication interruption time compared to our previous method.
Pre- and Postmeiotic Expression of Male Germ Cell-Specific Genes Throughout 2-Week Cocultures of Rat Germinal and Sertoli Cells1 (1997)

The present study was aimed at examining, by reverse transcription polymerase chain reaction, the expression of germ cell-specific genes in cocultures of Sertoli cells with either pachytene spermatocytes (PS) or round spermatids (RS). In situ hybridization studies showed that the mRNAs encoding phosphoprotein p19 and the testis-specific histone TH2B were specifically expressed in PS whereas those encoding the transition proteins TP1 and TP2 were specific to RS. This resulted in p19:TP1 and TH2B:TP2 ratios that were much higher in PS fractions than in RS fractions prepared by elutriation. When PS or RS were seeded on Sertoli cell monolayers in bicameral chambers, both the number and the viability of the cells decreased during the coculture. However, both parameters were equal to, or higher than, 60% after 2 wk. In PS-Sertoli cell cocultures, the ratios of p19:TP1 and TH2B:TP2 decreased dramatically during the second week of culture; this was due not only to a decrease in the levels of p19 and TH2B mRNAs but also to an enhancement in the relative amounts of TP1 and TP2 as compared to the amounts present on the first day of the coculture. Conversely, both ratios remained low in RS-Sertoli cell cocultures; this was due to a decrease in the levels of the four mRNAs studied during the coculture period. DNA flow cytometry studies showed the occurrence of a haploid cell population (1C) in PS-Sertoli cell cocultures from Day 2 onward, together with a decrease in the tetraploid cell population (4C). No such changes were observed in Sertoli cell-only cultures. By contrast, the haploid population decreased 3-fold during the first week in RS-Sertoli cell cocultures. Immunocytochemical studies demonstrated further that 5-bromo-2'-deoxyuridine-labeled PS of stages V-VIII were able to differentiate into RS under the present coculture conditions. Hence, although clearly imperfect, the present coculture system should help to clarify the local regulations governing spermatogenesis and should allow easier study of spermatogenic cell gene expression.
Electrospinning of chitosan solutions in acetic acid with poly(ethylene oxide) (2004)

Electrospinning of chitosan solutions with poly(ethylene oxide) (PEO) in an aqueous solution of 2 wt% acetic acid was studied. The properties of the chitosan/PEO solutions, including conductivity, surface tension and viscosity, were measured. Morphology of the electrospun chitosan/PEO was observed by using scanning electron micrographs. Results showed that the ultrafine fibers could be generated after addition of PEO in 2:1 or 1:1 mass ratios of chitosan to PEO from 4-6 wt% chitosan/PEO solutions at 15 kV voltage, 20 cm capillary-collector distance and flow rate 0.1 ml/h. During electrospinning of the chitosan/PEO solutions, ultrafine fibers with diameters from 80 nm to 180 nm were obtained, while microfibers with visually thicker diameters could be formed as well. Results of X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and differential scanning calorimeter exhibited the larger electrospun microfibers were almost entirely made from PEO, while the electrospun ultrafine fibers mainly contained chitosan.
Dopaminergic Modulation of Long-term Synaptic Plasticity in Rat Prefrontal Neurons (2003)

In rat prefrontal cortex (the prelimbic area of medial frontal cortex), the induction of long-term depression (LTD) and long-term potentiation (LTP) of glutamatergic synapses is powerfully modulated by dopamine. The presence of dopamine in the bathing medium facilitates LTD in slice preparations, whereas in the anesthetized intact brain, dopamine released from dopaminergic axon terminals in the prefrontal cortex facilitates LTP. Dopaminergic facilitation of LTD is at least partly achieved by postsynaptic biochemical mechanisms in which enzymatic processes triggered by dopamine receptor activation cooperate with those triggered by glutamate metabotropic receptor activation. Evidence suggests that dopamine facilitates LTP also in the slice condition. In this case, dopamine receptors must be pre-stimulated ('primed') before the application of high-frequency stimuli in the presence of dopamine. This procedure may mimic baseline stimulation of dopamine receptors that occurs under physiological conditions.
Human Anti-Macrophage Migration Inhibitory Factor Antibodies Inhibit Growth of Human Prostate Cancer Cells <i>In Vitro</i> and <i>In Vivo</i> (2013)

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, originally discovered for its eponymous effect and now known for pleiotropic biologic properties in immunology and oncology. Circulating MIF levels are elevated in several types of human cancer including prostate cancer. MIF is released presumably by both stromal and tumor cells and enhances malignant growth and metastasis by diverse mechanisms, such as stimulating tumor cell proliferation, suppressing apoptotic death, facilitating invasion of the extracellular matrix, and promoting angiogenesis. Recently described fully human anti-MIF antibodies were tested in vitro and in vivo for their ability to influence growth rate and invasion of the human PC3 prostate cancer cell line. In vitro, the selected candidate antibodies BaxG03, BaxB01, and BaxM159 reduced cell growth and viability by inhibiting MIF-induced phosphorylation of the central kinases p44/42 mitogen-activated protein kinase [extracellular signal-regulated kinase-1 and -2 (ERK1/2)] and protein kinase B (AKT). Incubation of cells in the presence of the antibodies also promoted activation of caspase-3/7. The antibodies furthermore inhibited MIF-promoted invasion and chemotaxis as transmigration through Matrigel along a MIF gradient was impaired. In vivo, pharmacokinetic parameters (half-life, volume of distribution, and bioavailability) of the antibodies were determined and a proof-of-concept was obtained in a PC3-xenograft mouse model. Treatment with human anti-MIF antibodies blunted xenograft tumor growth in a dose-dependent manner. We therefore conclude that the anti-MIF antibodies described neutralize some of the key tumor-promoting activities of MIF and thus limit tumor growth in vivo.
How to Train a Compact Binary Neural Network with High Accuracy? (2017)

How to train a binary neural network (BinaryNet) with both high compression rate and high accuracy on large scale dataset? We answer this question through a careful analysis of previous work on BinaryNets, in terms of training strategies, regularization, and activation approximation. Our findings first reveal that a low learning rate is highly preferred to avoid frequent sign changes of the weights, which often makes the learning of BinaryNets unstable. Secondly, we propose to use PReLU instead of ReLU in a BinaryNet to conveniently absorb the scale factor for weights to the activation function, which enjoys high computation efficiency for binarized layers while maintains high approximation accuracy. Thirdly, we reveal that instead of imposing L2 regularization, driving all weights to zero which contradicts with the setting of BinaryNets, we introduce a regularization term that encourages the weights to be bipolar. Fourthly, we discover that the failure of binarizing the last layer, which is essential for high compression rate, is due to the improper output range. We propose to use a scale layer to bring it to normal. Last but not least, we propose multiple binarizations to improve the approximation of the activations. The composition of all these enables us to train BinaryNets with both high compression rate and high accuracy, which is strongly supported by our extensive empirical study.
An ultra low-power peak-instant detector for a peak picking cochlear implant processor (2010)

This paper presents the design of a sub-threshold CMOS peak-instant detector to be used in a phase-locking peak-picking (PL-PP) bionic ear (BE) processor. The detector is formed by a current sample and hold circuit and a voltage comparator to perform the detection of occurrences of maximum and minimum values of the input. Circuit simulation results using CMOS 0.35 μm AMIS technology confirm that the proposed detector can be operated from a 1.2 V supply and consumes less than 1μW static power for detecting a 5kHz input signal (maximum frequency of the processor). For lower input frequencies the power consumption can be scaled down to further reduce the BE processor's power consumption.
Über die Desorption von positiven und negativen Ionen durch starke elektrische Felder (1956)

An Hand von Beobachtungen über die Feldelektronenemission wird gezeigt, daß sich aus dünnen, auf Wolframeinkristallspitzen aufgedampften Kaliumchloridschichten, deren Schichtdicke größer ist, als dem Minimum der Elektronenaustrittsarbeit entspricht, durch positive Felder positive Kaliumionen, durch negative Felder negative Chlorionen „abreißen“ lassen; im ersten Fall erscheint die effektive Austrittsarbeit der Elektronen nach dem Abreißvorgang vergrößert, im zweiten Fall vermindert. Aus den dünnsten, vermutlich monomolekularen Kaliumchloridschichten, gelingt es dagegen mit den hier verwendeten Feldstärken nur, positive Ionen, aber keine negativen Ionen abzureißen; dies wird verständlich, wenn man beachtet, daß aus energetischen Gründen das Chlor in unmittelbarer Berührung mit der Wolframoberfläche nicht als Ion, sondern nur als neutrales Atom gebunden sein kann, weil seine Elektronenaffinität (3,79 eV) kleiner als die Austrittsarbeit des Wolframs (4,5 eV) ist. Zur Deutung von früher untersuchten Abreißerscheinungen an gasbeladenen Wolframspitzen, die einer thermischen Nachbehandlung unterworfen waren, wird die Annahme vorgeschlagen, daß es sich bei den „Zentren“, die für die starken Intensitätsunterschiede im Feldelektronenemissionsbild solcher Schichten und für die Abreißerscheinungen verantwortlich sind, um überschüssige Metallatome handelt, die an bestimmten Stellen der Oberfläche der dünnen Oxyd- bzw. Carbidschicht eingebaut sind, mit der die gasbeladene Wolframoberfläche nach ihrer thermischen Nachbehandlung bedeckt ist.
A devised framework for content recommendation system using collaborative log mining (2013)

Internet is proving to play such an important role in our everyday life that it is almost impossible to survive without it. The World Wide Web (WWW) has inclined a lot to both users (visitors) as well as the web site owners. Enormous growth of World Wide Web increases the complexity for users to browse effectively and efficiently. Users visit a web site with a quench of getting useful information he/she is interested in. So as to satisfy user's objective and goal of searching web sites, betterment in web site design, web server activities are required to be changed as per users' interests. To achieve this analysis of user access pattern, which are captured in the form of log files is required, known as Web Usage Mining (WUM). Content recommendation system suggests and assists in selecting the content from wide and complex search space, which match with visitors interest, and which are unknown to them. Amount and type of interaction with web page captured at client side is an indicative measure of appropriateness of the content presented. Here in this paper, we provide detailed survey on various approaches for content recommendation and work done so far in this area, and proposed an hybrid approach that considers data gathered at client side along with web server's web log data, which will be used collaboratively to recommend a content.
A modified PSNR metric based on HVS for quality assessment of color images (2011)

Objective assessment of the image quality is of keen importance in numerous image processing applications. Various objective quality assessment indexes have been developed for this purpose, of which Peak signal-to-noise ratio (PSNR) is one of the simplest and commonly used. However, it sometimes fails to give result similar to as perceived by the Human Visual System (HVS). This paper presents a modified PSNR metric which is based on HVS characteristics and correlates well with the perceived image quality. It takes into account the error sensitivity, structural distortion and edge distortion in the image. The proposed metric uses RGB model for color images and empirically combine the effects of above distortion types on each of the color plane. Simulation results illustrate the precision and efficiency of the proposed metric in assessing the quality of color images for different types of degradations and show better correlation with the known characteristics of HVS in comparison to conventional PSNR metric.
A Comparison of Different Methods To Determine the Electron Diffusion Length in Dye-Sensitized Solar Cells (2009)

A new steady-state method for determination of the electron diffusion length in dye-sensitized solar cells (DSCs) is described and illustrated with data obtained using cells containing three different types of electrolyte. The method is based on using near-IR absorbance methods to establish pairs of illumination intensity for which the total number of trapped electrons is the same at open circuit (where all electrons are lost by interfacial electron transfer) as at short circuit (where the majority of electrons are collected at the contact). Electron diffusion length values obtained by this method are compared with values derived by intensity-modulated methods and by impedance measurements under illumination. The results indicate that the values of electron diffusion length derived from the steady-state measurements are consistently lower than the values obtained by the non-steady-state methods. For all three electrolytes used in the study, the electron diffusion length was sufficiently high to guarantee electron collection efficiencies greater than 90%. Measurement of the trap distributions by near-IR absorption confirmed earlier observations of much higher electron trap densities for electrolytes containing Li+ ions. It is suggested that the electron trap distributions may not be intrinsic properties of the TiO2 nanoparticles but may be associated with electron−ion interactions.
Up-regulation of miR-21 Mediates Resistance to Trastuzumab Therapy for Breast Cancer (2011)

Trastuzumab resistance emerges to be a major issue in anti-human epidermal growth factor receptor 2 (HER2) therapy for breast cancers. Here, we demonstrated that miR-21 expression was up-regulated and its function was elevated in HER2(+) BT474, SKBR3, and MDA-MB-453 breast cancer cells that are induced to acquire trastuzumab resistance by long-term exposure to the antibody, whereas protein expression of the PTEN gene, a miR-21 target, was reduced. Blocking the action of miR-21 with antisense oligonucleotides re-sensitized the resistant cells to the therapeutic activities of trastuzumab by inducing growth arrest, proliferation inhibition, and G(1)-S cell cycle checking in the presence of the antibody. Ectopic expression of miR-21 in HER2(+) breast cancer cells confers resistance to trastuzumab. Rescuing PTEN expression with a p3XFLAG-PTEN-mut construct with deleted miR-21 targeting sequence at its 3' UTR restored the growth inhibition of trastuzumab in the resistant cells by inducing PTEN activation and AKT inhibition. In vivo, administering miR-21 antisense oligonucleotides restored trastuzumab sensitivity in the resistant breast cancer xenografts by inducing PTEN expression, whereas injection of miR-21 mimics conferred trastuzumab resistant in the sensitive breast tumors via PTEN silence. Up-regulatin of miR-21 in tumor biopsies obtained from patients receiving pre-operative trastuzumab therapy was associated with poor trastuzumab response. Therefore, miR-21 overexpression contributes to trastuzumab resistance in HER2(+) breast cancers and antagonizing miR-21 demonstrates therapeutic potential by sensitizing the malignancy to anti-HER2 treatment.
Privatrecht in Mexiko. Anthropologische, soziologische und rechtstatsächliche Studien (1977)

"Law and Politics in Africa, Asia and Latin America" analyses legal and constitutional developments in all states or regions outside of Europe as well as their regional and international integration. Founded in 1968 and inspired by decolonization and the idea of a cooperative new beginning, the Journal also promotes a special interest in contributions on 'Law and development'. The journal aims to provide a forum for a variety of perspectives on these fields of interest, be they focused on one country or comparative, theoretical or methodological in nature.
Identifying personal microbiomes using metagenomic codes (2015)

Community composition within the human microbiome varies across individuals, but it remains unknown if this variation is sufficient to uniquely identify individuals within large populations or stable enough to identify them over time. We investigated this by developing a hitting set-based coding algorithm and applying it to the Human Microbiome Project population. Our approach defined body site-specific metagenomic codes: sets of microbial taxa or genes prioritized to uniquely and stably identify individuals. Codes capturing strain variation in clade-specific marker genes were able to distinguish among 100s of individuals at an initial sampling time point. In comparisons with follow-up samples collected 30-300 d later, ∼30% of individuals could still be uniquely pinpointed using metagenomic codes from a typical body site; coincidental (false positive) matches were rare. Codes based on the gut microbiome were exceptionally stable and pinpointed >80% of individuals. The failure of a code to match its owner at a later time point was largely explained by the loss of specific microbial strains (at current limits of detection) and was only weakly associated with the length of the sampling interval. In addition to highlighting patterns of temporal variation in the ecology of the human microbiome, this work demonstrates the feasibility of microbiome-based identifiability-a result with important ethical implications for microbiome study design. The datasets and code used in this work are available for download from huttenhower.sph.harvard.edu/idability.
Synthese de Nouveaux Derives Phosphones a Chaine Perfluoree et Leurs Proprietes Adhesives Sur Acier (2002)

Abstract Ce mémoire décrit la synthèse de phosphonates comportant une chaîne perfluorée. Ces composés sont obtenus par la télomérisation d'allylphosphonates de dialkyle en présence d'un agent de transfert fluoré de type mercaptan. Ensuite, nous employons deux méthodes de déalkylation menant sélectivement soit au monoacide soit au diacide phosphonique. Tous ces produits comprenant une extrémité de chaîne phosphonée, sous forme acide ou ester, ont été caractérisés et leur adhésion respective sur des plaques d'acier est étudiée. Ces tests montrent que le monoacide phosphonique est un excellent promoteur d'adhésion et qu'il est aussi efficace que le diacide. This article describes the synthesis of phosphonic derivatives bearing a perfluorinated chain. These compounds have been synthetized by telomerization of dialkyl allylphosphonate with a fluorinated transfer agent type mercaptan. Then two methods of dealkylation leading selectively were used to mono or to diacid phosphonic moieties. All the products bearing phosphonic end-groups, more or less acidic, have been characterized and their own adhesion on steel plates is studied. These tests show that phosphonic monoacid is an excellent adhesion promoter on steel, as efficient as the diacid compound. Keywords: Adhesion On SteelDealkylationPhosphonatePhosphonic AcidTelomerization
Recent Advances in TiO<sub>2</sub>‐Based Nanostructured Surfaces with Controllable Wettability and Adhesion (2015)

Bioinspired surfaces with special wettability and adhesion have attracted great interest in both fundamental research and industry applications. Various kinds of special wetting surfaces have been constructed by adjusting the topographical structure and chemical composition. Here, recent progress of the artificial superhydrophobic surfaces with high contrast in solid/liquid adhesion has been reviewed, with a focus on the bioinspired construction and applications of one-dimensional (1D) TiO2-based surfaces. In addition, the significant applications related to artificial super-wetting/antiwetting TiO2-based structure surfaces with controllable adhesion are summarized, e.g., self-cleaning, friction reduction, anti-fogging/icing, microfluidic manipulation, fog/water collection, oil/water separation, anti-bioadhesion, and micro-templates for patterning. Finally, the current challenges and future prospects of this renascent and rapidly developing field, especially with regard to 1D TiO2-based surfaces with special wettability and adhesion, are proposed and discussed.
Design of a conflict detection algorithm for the Center/TRACON automation system (2002)

An algorithm for detecting and analyzing potential enroute conflicts has been designed and implemented within the Center-TRACON Automation System (CTAS). The design uses the 4D trajectories provided by CTAS to produce a set of probable future conflicts, and assists the enroute sector controller in efficiently resolving these conflicts. Conflicts are detected via comparisons of trajectories at closely spaced time instants, with measures taken to limit the computations required to complete the search. Performance tests indicate more than 800 aircraft can be processed by the conflict detection and analysis algorithm within a search cycle of 10 seconds. This suggests that the search algorithm easily meets the performance requirements for an automated conflict detection and resolution tool in the current air traffic system. The algorithm includes a trial resolution functionality which automatically detects conflicts of proposed resolutions, and gives near instantaneous feedback to controller input. Field evaluation of the Conflict Probe will be conducted at the Denver and Fort Worth Air Route Traffic Control Centers (ARTCC) beginning in September, 1997.