gebhart/patrepeval huggingface dataset:
Assessment of Nigerian Calcium Bentonite as Cement Replacement for Shallow depth Oil Well Cementing Operation (2022)

This study assessed the rheological and mechanical properties of Nigerian Ewu-Obi Calcium Bentonite (ECaB) as cement partial replacement for shallow depth cementing operations using experimental design and response surface methodology. Rheological properties, Thickening Time (TT), and Compressive Strength (CS) were measured using a 12-speed rotational viscometer, High-Pressure High Temperature (HPHT) Consistometer, and Ultrasonic Cement Analyzer, respectively. The effect of the increase in the concentration of bentonite clay as well as its interaction with other cement additives (accelerator and antifoam) on plastic viscosity (PV), yield point (Yp), fluid loss (FL), TT, and CS were investigated. The result shows that the optimum replaceable percentage of ECaB in class G cement, accelerator, and antifoam is 23.5, 7.5, and 0.95 wt %, respectively. At optimum conditions, the PV (17.5±1.35 cp), FL (20 ml/30 min/100 psi), TT (228±16.4 min), and CS24 (614±0.57 psi) obtained agreed with the API standard and compared favorably with literature.
Training in flexible, intensive insulin management to enable dietary freedom in people with type 1 diabetes: dose adjustment for normal eating (DAFNE) randomised controlled trial (2002)

Skills training promoting dietary freedom improved quality of life and glycaemic control in people with type 1 diabetes without worsening severe hypoglycaemia or cardiovascular risk. This approach has the potential to enable more people to adopt intensive insulin treatment and is worthy of further investigation.
Endoscopic Closure of Gastrointestinal Leaks (2009)

Surgery has been the mainstay of therapy in patients with gastrointestinal perforations. This paradigm started to shift with the development of techniques for endoscopic closure of gastrointestinal perforations. A detailed review of the literature on this subject, along with a commentary on practical aspects in the management of patients with gastrointestinal leaks, is provided here.
Sensitization of multidrug-resistant mouse ascites HD33 and Chinese hamster ovary CHRC5S3 cells by a photoreactive vinblastine derivative, NAPAVIN. (1990)

We have synthesized a new photoreactive vinblastine derivative, 3-[[[2-amino(4-azido-2-nitrophenyl)ethyl]amino] carbonyl]-O4-deacetyl-3-de-(methoxycarbonyl)-vincaleukoblastine (NAPAVIN), which absorbs light at around 450 nm. We report here its effects in vitro on multidrug-resistant mouse HD33 Ehrlich-Lettré ascites cells, on Chinese hamster ovary CHRC5S3 cells, on the corresponding drug-sensitive cells, on chemosensitive rat TMA1 mammary carcinoma, and on human SW48 colon carcinoma cells. Cells were incubated with the drug prior to activation by laser light at 457 nm. In Vinca alkaloid-sensitive cells, the short-term effects (30 to 72 h after treatment) of NAPAVIN with and without irradiation on cell proliferation are comparable to those of vinblastine. In drug-resistant cells, NAPAVIN without irradiation reduces the 50% inhibitory concentration 2- to 9-fold, compared with vinblastine. Upon irradiation with an argon laser at 457 nm, the concentration causing 50% inhibition of cell proliferation is further decreased to a total of 9- to 33-fold. Long-term effects (up to 6 wk after treatment) are seen in both sensitive and resistant cells. A single dose of the photoactivated drug causes a 6- to 9-fold larger delay (5 wk) in proliferation, compared with an equal dose of vinblastine.
Thermally tunable silicon photonic microdisk resonator with transparent graphene nanoheaters (2016)

Efficient tunable photonic integrated devices are important for the realization of reconfigurable photonic systems. Thermal tuning is a convenient and effective approach, and silicon’s large heat conductivity, thermo-optical coefficient, and CMOS fabrication compatibility make it a good candidate material for tunable optical microcavities, which are versatile elements in low-cost, large-scale photonic integrated circuits. Metal heaters are traditionally used for tuning, and a thick SiO2 upper-cladding layer is usually needed to prevent light absorption by the metal since that could reduce response speed and heating efficiency. In this paper, we propose and experimentally demonstrate thermally tunable silicon photonic microdisk resonators by introducing transparent graphene nanoheaters, which contact the silicon core directly without any isolator layer. The theoretical and experimental results show that the transparent graphene nanoheaters improve the heating efficiency, the temporal response, and the achievable temperature in comparison with a traditional metal heater. Furthermore, the graphene nanoheater is convenient for use in ultrasmall nanophotonic integrated devices due to its single-atom thickness and excellent flexibility. Both experiments and simulations show that the transparent graphene nanoheater is a promising option for other thermally tunable photonic integrated devices such as optical filters and switches.
Downregulation of MicroRNA-130a Contributes to Endothelial Progenitor Cell Dysfunction in Diabetic Patients via Its Target Runx3 (2013)

Dysfunction of endothelial progenitor cells (EPCs) contributes to diabetic vascular disease. MicroRNAs (miRs) have emerged as key regulators of diverse cellular processes including angiogenesis. We recently reported that miR-126, miR-130a, miR-21, miR-27a, and miR-27b were downregulated in EPCs from type II diabetes mellitus (DM) patients, and downregulation of miR-126 impairs EPC function. The present study further explored whether dysregulated miR-130a were also related to EPC dysfunction. EPCs were cultured from peripheral blood mononuclear cells of diabetic patients and healthy controls. Assays on EPC function (proliferation, migration, differentiation, apoptosis, and colony and tubule formation) were performed. Bioinformatics analyses were used to identify the potential targets of miR-130a in EPCs. Gene expression of miR-103a and Runx3 was measured by real-time PCR, and protein expression of Runx3, extracellular signal-regulated kinase (ERK), vascular endothelial growth factor (VEGF) and Akt was measured by Western blotting. Runx3 promoter activity was measured by luciferase reporter assay. A miR-130a inhibitor or mimic and lentiviral vectors expressing miR-130a, or Runx3, or a short hairpin RNA targeting Runx3 were transfected into EPCs to manipulate miR-130a and Runx3 levels. MiR-130a was decreased in EPCs from DM patients. Anti-miR-130a inhibited whereas miR-130a overexpression promoted EPC function. miR-130a negatively regulated Runx3 (mRNA, protein and promoter activity) in EPCs. Knockdown of Runx3 expression enhanced EPC function. MiR-130a also upregulated protein expression of ERK/VEGF and Akt in EPCs. In conclusion, miR-130a plays an important role in maintaining normal EPC function, and decreased miR-130a in EPCs from DM contributes to impaired EPC function, likely via its target Runx3 and through ERK/VEGF and Akt pathways.
Applications of linear Hall-effect sensors on angular measurement (2011)

The non-contact type application on the permanent magnet and linear Hall-effect sensor gauging rotary system is introduced in this paper. For such a contactless case, there is no wear. This provides a longer life span in association, and in particular, high reliability to achieve continuous use. The main component of the angular position estimation system is the linear Hall-effect sensor. The angle gauge depends on the Hall voltage at the rotation of the magnetic induction. The advantage of the system is its reliable operation in special environmental conditions, such as high vibration, humidity, or dust. Higher accuracy and precision will be achieved, as shown by the experimental results, and it can be widely used in the angular measurement field.
Morphological studies on the blends of poly(butylene terephthalate) and bisphenol‐A polycarbonate (1990)

Abstract The morphology of the blends of poly(butylene terephthalate) (PBT) and bisphenol‐A polycarbonate (PC) crystallized from the melt were studied by density measurement and small angle light scattering techniques. Rate of crystallization of these blends was found to be slower with increasing amount of PC. The Avrami exponent n for the blends was calculated and related to the shape of superstructures formed. H v and V v scattering patterns as seen by small angle light scattering were analyzed to determine the nature, shape, and size of the superstructures. The changes in the superstructure formation with increasing amount of PC in these blends have been analyzed.
Saliva levels of Abeta1-42 as potential biomarker of Alzheimer's disease: a pilot study (2010)

We suggest that saliva Aβ42 levels could be considered a potential peripheral marker of AD and help discrimination from other types of neurodegenerative disorders. We propose a new and promising biomarker for early AD.
Measuring diagnostic and predictive accuracy in disease management: an introduction to receiver operating characteristic (ROC) analysis (2006)

Diagnostic or predictive accuracy concerns are common in all phases of a disease management (DM) programme, and ultimately play an influential role in the assessment of programme effectiveness. Areas, such as the identification of diseased patients, predictive modelling of future health status and costs and risk stratification, are just a few of the domains in which assessment of accuracy is beneficial, if not critical. The most commonly used analytical model for this purpose is the standard 2 x 2 table method in which sensitivity and specificity are calculated. However, there are several limitations to this approach, including the reliance on a single defined criterion or cut-off for determining a true-positive result, use of non-standardized measurement instruments and sensitivity to outcome prevalence. This paper introduces the receiver operator characteristic (ROC) analysis as a more appropriate and useful technique for assessing diagnostic and predictive accuracy in DM. Its advantages include; testing accuracy across the entire range of scores and thereby not requiring a predetermined cut-off point, easily examined visual and statistical comparisons across tests or scores, and independence from outcome prevalence. Therefore the implementation of ROC as an evaluation tool should be strongly considered in the various phases of a DM programme.
Comparative pharmacokinetics and safety of a novel lyophilized amphotericin B lecithin-based oil-water microemulsion and amphotericin B deoxycholate in animal models (2003)

Amphotericin B (AmB) has been a most effective systemic antifungal agent, but its use is circumscribed by the dose-limiting toxicity of the conventional micellar dispersion formulation Fungizone (D-AmB). To lower AmB-associated toxicity, AmB may be integrated into oil-in-water lecithin-based microemulsions. The present study compares the pharmacokinetic characteristics of D-AmB with the alternative formulation of AmB in microemulsion (M-AmB), which has proved effective in a murine candidiasis model. Both formulations were given by intravenous bolus: D-AmB 1 mg/kg, and M-AmB 0.5, 1 or 2 mg/kg. The pharmacokinetics of D-AmB and M-AmB have several differences, specifically with regard to the respective Cmax and AUC0- infinity values. Elimination of AmB from serum was biphasic for both M-AmB and D-AmB. Single-dose D-AmB (1 mg/kg) achieved a Cmax of 3.89 +/- 0.48 mg/L and an AUC0- infinity of 32.28 +/- 7.31 mg.h/L, whereas single-dose M-AmB (1 mg/kg) by comparison achieved a lower Cmax (2.92 +/- 0.54 mg/L) and a lower AUC0- infinity (21.89 +/- 5.17 mg.h/L). To evaluate the safety of M-AmB, a multiple-dose toxicity study was performed in groups of 10 mice, each receiving D-AmB 1 mg/kg, or M-AmB 1, 1.5, 2 or 3 mg/kg. The findings suggest that, in comparison with D-AmB, M-AmB produces no histologically demonstrable renal lesions, or changes in clinical chemistry.
Femoral bone and cartilage wear is predictable at 0° and 90° in the osteoarthritic knee treated with total knee arthroplasty (2014)

IV.
Effect of terrestrial and marine humics on copper speciation in an estuary in the Great Barrier Reef Lagoon (1988)

Studies carried out over several years on a tropical estuary, the Ross River Estuary, have shown that copper speciation is influenced by both terrestrial and marine humic substances. While terrestrial humic substances are mobilized by high freshwater runoff in the monsoonal season, Trichodesmium blooms mobilize high concentrations of marine humics to the inshore zone and increase labile forms of copper. The marine humics are more soluble than the terrestrial humics and persist in coastal waters of the Great Barrier Reef lagoon for many months prior to the wet season.
Evolution of <i>β</i> -Cell Replacement Therapy in Diabetes Mellitus: Pancreas Transplantation (2011)

Diabetes mellitus remains one of the leading causes of morbidity and mortality worldwide. According to the Centers for Disease Control and Prevention, approximately 23.6 million people in the United States are affected. Of these individuals, 5-10% have been diagnosed with type 1 diabetes mellitus (TIDM), an autoimmune disease. Although it often appears in childhood, T1DM may manifest at any age. The effects of T1DM can be devastating, as the disease often leads to significant secondary complications, morbidity, and decreased quality of life. Since the late 1960s, surgical treatment for diabetes mellitus has continued to evolve and has become a viable alternative to chronic insulin administration. In this review, the historical evolution, current status, graft efficacy, benefits, and complications of pancreas transplantation are explored.
Tunneling-Current-Induced Light Emission from Copper Phthalocyanine Thin Films (2006)

Molecular fluorescence induced by tunneling electrons from a scanning tunneling microscope was investigated for copper phthalocyanine thin films deposited on the highly ordered pyrolytic graphite and the Au(111) substrates. No light emission was observed from the copper phthalocyanine thin films on the highly ordered pyrolytic graphite substrate, on the other hand, the fluorescence of copper phthalocyanine on the Au(111) substrate was observed with plasmon-mediated light emission related to the Au(111) substrate. These results are due to the differences in the charge injection efficiency and surface plasmon resonance mode of two substrates. The obtained fluorescence did not satisfy the quantum cutoff condition, that is, observed photon energy was higher than the energy of injected electrons. [DOI: 10.1380/ejssnt.2006.559]
Laboratory Investigation:Automatic Identification of Gray Matter Structures from MRI to Improve the Segmentation of White Matter Lesions (1995)

The segmentation of MRI scans of patients with white matter lesions (WML) is difficult because the MRI characteristics of WML are similar to those of gray matter. Intensity-based statistical classification techniques misclassify some WML as gray matter and some gray matter as WML.We developed a fast elastic matching algorithm that warps a reference data set containing information about the location of the gray matter into the approximate shape of the patient's brain. The region of white matter was segmented after segmenting the cortex and deep gray matter structures. The cortex was identified by using a three-dimensional, region-growing algorithm that was constrained by anatomical, intensity gradient, and tissue class parameters. White matter and WML were then segmented without interference from gray matter by using a two-class minimum-distance classifier.Analysis of double-echo spin-echo MRI scans of 16 patients with clinically determined multiple sclerosis (MS) was carried out. The segmentation of the cortex and deep gray matter structures provided anatomical context. This was found to improve the segmentation of MS lesions by allowing correct classification of the white matter region despite the overlapping tissue class distributions of gray matter and MS lesion.
Nonmanifold subdivision (2001)

Commonly-used subdivision schemes require manifold control meshes and produce manifold surfaces. However, it is often necessary to model nonmanifold surfaces, such as several surface patches meeting at a common boundary. In this paper, we describe a subdivision algorithm that makes it possible to model nonmanifold surfaces. Any triangle mesh, subject only to the restriction that no two vertices of any triangle coincide, can serve as an input to the algorithm. Resulting surfaces consist of collections of manifold patches joined along nonmanifold curves and vertices. If desired, constraints may be imposed on the tangent planes of manifold patches sharing a curve or a vertex. The algorithm is an extension of a well-known Loop subdivision scheme, and uses techniques developed for piecewise smooth surfaces.
Analogs of angiotensin II. I. Solid phase synthesis (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalogs of angiotensin II. I. Solid phase synthesisN. C. Chaturvedi, Won Kil. Park, R. R. Smeby, and F. M. BumpusCite this: J. Med. Chem. 1970, 13, 2, 177–181Publication Date (Print):March 1, 1970Publication History Published online1 May 2002Published inissue 1 March 1970https://pubs.acs.org/doi/10.1021/jm00296a002https://doi.org/10.1021/jm00296a002research-articleACS PublicationsRequest reuse permissionsArticle Views127Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice (1997)

The ob gene product, leptin, causes significant and dose-dependent inhibition of basal and insulin-stimulated glycogen synthesis in isolated soleus muscle from ob/ob mice, and a smaller, non-significant inhibition in muscle from wild-type mice. Leptin had no inhibitory effect on glycogen synthesis in soleus muscle from the diabetic (db/db) mice, which lack the functional leptin receptor. The full-length leptin receptor (Ob-Rb), is expressed in soleus muscle of both ob/ob and wild-type mice, however with no detectable differences in expression level. These results suggest that hyperleptinaemia may attenuate insulin action on glucose storage in skeletal muscle.
Influence of Sugar Type on the Pattern of Acid Production by Streptococcus mutans (1972)

Acid was produced rapidly during incubation of Streptococcus mutans with monosaccharides glucose and fructose, and was delayed by one hour in the presence of sucrose. A significant degree of potentiation occurred when both glucose and fructose were present in the incubation medium. This could be because of a substrate-controlled transport mechanism in the cell membrane.
Radiation patterns from coupled photonic crystal nanocavities (2011)

We report on far field measurements on two coupled photonic crystal nanocavities. The distinct features of the antisymmetric modes (minima of intensity at zero-emission angles) allow us to demonstrate a π-phase difference between the cavity fields, a clear signature of evanescent coupling. Good agreement between experimental results and simulated radiation patterns has been found.
Lipid Nanoparticulate Drug Delivery Systems: A Revolution in Dosage Form Design and Development (2012)

© 2012 Attama et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Lipid Nanoparticulate Drug Delivery Systems: A Revolution in Dosage Form Design and Development
Radiomics: Data Are Also Images (2019)

The aim of this review is to provide readers with an update on the state of the art, pitfalls, solutions for those pitfalls, future perspectives, and challenges in the quickly evolving field of radiomics in nuclear medicine imaging and associated oncology applications. The main pitfalls were identified in study design, data acquisition, segmentation, feature calculation, and modeling; however, in most cases, potential solutions are available and existing recommendations should be followed to improve the overall quality and reproducibility of published radiomics studies. The techniques from the field of deep learning have some potential to provide solutions, especially in terms of automation. Some important challenges remain to be addressed but, overall, striking advances have been made in the field in the last 5 y.
An Electronic Intelligent Hotel Management System for International Marketplace (2011)

To compete with the international market place, it is crucial for hotel industry to be able to continually improve its services for tourism. In order to construct an electronic marketplace (e-market), it is an inherent requirement to build a correct architecture with a proper approach of an intelligent systems embedded on it. This paper introduces a web based intelligent that helps in maintaining a hotel by reducing the immediate involvement of manpower. The hotel reception policy, room facilities and intelligent personalization promotion are the main focuses of this paper. An intelligent search for existing boarders as well as room availability is incorporated in the system. For each of the facilities, a flow chart has been developed which confirms the techniques and relevant devices used in the system. By studying several scenarios, the paper outlines a number of techniques for realization of the intelligent hotel management system. Special attention is paid to the security and also prevention of power and water wastages. In this power saving scenery, an image processing approach is taken to detect the presence of any people and the darkness in a particular room. Moreover, this proposed automated computerized scheme also takes an account of the cost advantage. Considering the scarcity of manpower in several countries, the objective of this paper is to initiate the discussion and research for making the proposed systems more commercialized.