gebhart/patrepeval huggingface dataset:
Use of eluted peptide sequence data to identify the binding characteristics of peptides to the insulin-dependent diabetes susceptibility allele HLA-DQ8 (DQ 3.2) (1997)

HLA-DQ8 (A1*0301, B1*0302) and -DQ2 (A1*0501, B1*0201) are both associated with diseases such as insulin-dependent diabetes mellitus and coeliac disease. We used the technique of pool sequencing to look at the requirements of peptides binding to HLA-DQ8, and combined these data with naturally sequenced ligands and in vitro binding assays to describe a novel motif for HLA-DQ8. The motif, which has the same basic format as many HLA-DR molecules, consists of four or five anchor regions, in the positions from the N-terminus of the binding core of n, n + 3, n + 5/6 and n + 8, i.e. P1, P4, P6/7 and P9. P1 and P9 require negative or polar residues, with mainly aliphatic residues at P4 and P6/7. The features of the HLA-DQ8 motif were then compared to a pool sequence of peptides eluted from HLA-DQ2. A consensus motif for the binding of a common peptide which may be involved in disease pathogenesis is described. Neither of the disease-associated alleles HLA-DQ2 and -DQ8 have Asp at position 57 of the beta-chain. This Asp, if present, may form a salt bridge with an Arg at position 79 of the alpha-chain and so alter the binding specificity of P9. HLA-DQ2 and -DQ8 both appear to prefer negatively charged amino acids at P9. In contrast, HLA-DQ7 (A1*0301, B1*0301), which is not associated with diabetes, has Asp at beta 57, allowing positively charged amino acids at P9. This analysis of the sequence features of DQ-binding peptides suggests molecular characteristics which may be useful to predict epitopes involved in disease pathogenesis.
The National Microbial Pathogen Database Resource (NMPDR): a genomics platform based on subsystem annotation (2006)

in selected Category B pathogens. NMPDR contains the complete genomes of $50 strains of pathogenic bacteria that are the focus of our curators, as well as >400 other genomes that provide a broad context for comparative analysis across the three phylogenetic Domains. NMPDR integrates complete, public genomes with expertly curated biological subsystems to provide the most consistent genome annotations. Subsystems are sets of functional roles related by a biologically meaningful organizing principle, which are built over large collections of genomes; they provide researchers with consistent functional assignments in a biologically structured context. Investigators can browse subsystems and reactions to develop accurate reconstructions of the metabolic networks of any sequenced organism. NMPDR provides a comprehensive bioinformatics platform, with tools and viewers for genome analysis. Results of precomputed gene clustering analyses can be retrieved in tabular or graphic format with one-click tools. NMPDR tools include Signature Genes, which finds the set of genes in common or that differentiates two groups of organisms. Essentiality data collated from genome-wide studies have been curated. Drug target identification and high-throughput, in silico, compound screening are in development.
Posttransplantation Relapse of FSGS Is Characterized by Glomerular Epithelial Cell Transdifferentiation (2001)

This study examined six cases of idiopathic nephrotic syndrome with primary lesions of focal segmental glomerulosclerosis (FSGS) that relapsed after renal transplantation. The glomerular lesions comprised the cellular, the collapsing, and the scar variants of FSGS and showed shedding of large round cells into Bowman's space and within the tubular lumens. Immunohistochemistry and confocal laser microscopy carried out on kidneys with FSGS relapse disclosed several phenomena. (1) Some podocytes that expressed podocalyxin, synaptopodin, and glomerular epithelial protein-1 were detached from the tuft and were free in the urinary space. (2) In the cellular variant, most podocytes had lost podocyte-specific epitopes (podocalyxin, synaptopodin, glomerular epithelial protein-1, Wilm's tumor protein-1, complement receptor-1, and vimentin). In the scar variant, these podocyte markers were absent from cobblestone-like epithelial cells and from pseudotubules. (3) Podocytes had acquired expression of various cytokeratins (CK; identified by the AE1/AE3, C2562, CK22, and AEL-KS2 monoclonal antibodies) that were not found in the podocytes of control glomeruli. Parietal epithelial cells expressed AE1/AE3 CK that were faintly, if ever, found on the parietal epithelial cells of normal glomeruli. (4) Numerous cells located at the periphery of the tuft or free in Bowman's space and within tubular lumens expressed macrophagic epitopes (identified by PGM1 [CD68], HAM56, and 25F9 monoclonal antibodies). These macrophage-like cells expressed the activation epitopes HLA-DR and CD16. (5) A number of these cells coexpressed podocalyxin + AE1/AE3 CK, podocalyxin + CD68, and CD68 + AE1/AE3. These findings suggest that in primary FSGS relapsing on transplanted kidneys, some "dysregulated" podocytes, occasionally some parietal epithelial cells, and possibly some tubular epithelial cells undergo a process of transdifferentiation. This process of transdifferentiation was especially striking in podocytes that acquired macrophagic and CK epitopes that are absent from normal adult and fetal podocytes.
Die umsetzung von azlactonen mit CH‐aciden verbindungen. 2. Mitteil (1980)

Abstract Cyanessigester, Malonester, Methansulfonylessigester werden durch Alkylidenazlactone acyliert. Die Primärprodukte kondensieren leicht zu Alkylidentetramsäuren. Die Acylcyanessigester 2 isomerisieren unter dem Einfluß von Säuren zu Aminopyrrolinonen 3 .
Personalized Image-based User Authentication using Wearable Cameras (2016)

Personal devices (e.g. laptops, tablets, and mobile phones) are conventional in daily life and have the ability to store users' private data. The security problems related to these appliances have become a primary concern for both users and researchers. In this paper, we analyse first-person-view videos to develop a personalized user authentication mechanism. Our proposed algorithm generates provisional image-based passwords which benefit a variety of purposes such as unlocking a mobile device or fallback authentication. First, representative frames are extracted from the egocentric videos. Then, they are split into distinguishable segments before a clustering procedure is applied to discard repetitive scenes. The whole process aims to retain memorable images to form the authentication challenges. We integrate eye tracking data to select informative sequences of video frames and suggest a blurriness-based method if an eye-facing camera is not available. To evaluate our system, we perform experiments in different settings including object-interaction activities and traveling contexts. Even though our mechanism produces variable graphical passwords, the log-in effort for the user is comparable with approaches based on static challenges. We verified the authentication challenges in the presence of a random and an informed attacker who is familiar with the environment and observed that the time required and the number of attempts are significantly higher than for the legitimate user, making it possible to detect attacks on the authentication system.
Research on the integration of RTCWeb technology with IP multimedia subsystem (2012)

Over the last few years, some significant evolutions such as intelligent mobile phone, web 2.0, html5 and RTCWeb (real time communication in web browsers) take the Internet into the Telecommunication world. The gap between Telecom and Web Worlds is becoming smaller and smaller. In this paper, we research on the integration of RTCWeb technology with IP multimedia subsystem. We introduce the development situation of RTCWeb technology and give the analysis of why we need the integration and the aim of the integration. We give solution on how to realize the integration from two points of view: protocol, network and route. Through added IMS-RTCWeb interworking gateway and the suitable protocols, we can construct the integration architecture. At the last, we list the problems on this integration topic and give the prospect of future work on this topic.
Biomimetic pseudopolyrotaxane prodrug micelles with high drug content for intracellular drug delivery (2013)

For the first time, pseudopolyrotaxane prodrug micelles with high drug content were prepared in water, which could be used for cancer therapy. It is anticipated that this facile strategy may open a novel avenue for the development of multifunctional drug delivery systems.
H. A. Major (1910)

H. A. Major Get access S. J. A. F. S. J. A. F. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s11-II, Issue 33, 13 August 1910, Page 129, https://doi.org/10.1093/nq/s11-II.33.129b Published: 13 August 1910
Online forums supporting grassroots participation in emergency preparedness and response (2007)

"When danger arises, the rule in normal situations is for people to help those next to them before they help themselves."
Controlled polymerisation of lactide using an organo-catalyst in supercritical carbon dioxide (2011)

The controlled, ring-opening polymerisation of DL-lactide in supercritical carbon dioxide (scCO2) using benzyl alcohol as an initiator and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an organo-catalyst, is reported. Despite reports of DBU being efficiently converted to a carbonate salt in the presence of a proton source, it was found that DBU was still an efficient catalyst for the ring opening polymerisation of DL-lactide. Matrix-assisted laser desorption ionisation time of flight mass spectroscopy and 1H nuclear magnetic resonance analysis demonstrated that end-group fidelity was maintained on the resulting polymer and significant transesterification was not observed under anhydrous conditions. We report a truly ‘green’ process for the synthesis of polylactic acid (PLA) with the total absence of potentially toxic organic solvents and inorganic catalysts. In addition, the reaction in scCO2 is conducted at temperatures much lower than that required for bulk polymerisation of LA.
Specific interaction between cartilage proteoglycans and hyaluronic acid at the chondrocyte cell surface (1983)

Binding of exogenous [35S]sulphate-labelled cartilage proteoglycans to cells was studied with suspension cultures of calf articular-cartilage chondrocytes. Proteoglycans interact with hyaluronic acid at the cell surface via their hyaluronic acid-binding region. The binding is time-dependent and saturable, but does not appear to be freely reversible. The bound 35S-labelled proteoglycans are located at the cell surface, and only small proportions of the proteoglycans are internalized.
Non-competitive AMPA Antagonists of 2,3-Benzodiazepine Type (2002)

The discovery of the selective AMPA antagonist character of 2,3-benzodiazepine derivative GYKI 52466 (5) in the late eighties and the recognition of the non-competitive nature of its mode of action some years later set off the world-wide search for novel class of drugs. Notably the quest to develop new antiepileptic and neuroprotective medicines, which allosterically inhibit the AMPA sensitive glutamate operated channels. This review summarises our present knowledge about the allosteric site, dubbed "GYKI site" where the 2,3-benzodiazepines are supposed to bind to. The structure-activity relationships among AMPA antagonist 2,3-benzodiazepines and their structural analogues with similar biological profile are reviewed in a possibly comprehensive fashion. The chemical synthesis of 2,3-benzodiazepines is shortly described. The in vitro and in vivo experimental methods used for pharmacological characterisation of the biologically active compounds are briefly explained. Finally the therapeutic potential of 2,3-benzodiazepines i.e. the main fields of their clinical utility are outlined with special regard to talampanel (20) in the light of the ongoing clinical trials with this new drug candidate.
Diversity Of Online News Media (2021)

This study content analyzed news reports of four major online news media in Korea to examine whether online news media provide the diversity of news to the society. In this study, diversity of news was operationally defined in terms of news sources and news frames. The result showed that the online news media showed diversity in their news report in terms of both news sources and use of frames. Among the four online news media under study, Ohmynews showed striking contrast to the rest of the media in the use of news sources and frames. Ohmynews showed the highest rate of news sources per news article; moved directly to the stage of controversy while minimizing or even omitting the stage of explanation of issues; focused more on the cause of issue; reported the public issues in terms of conflict; developed news stories about public issues through human interest; was less interested in the consequences than in the nature of issue; and had considerable amount of news stories written by ordinary citizen reporters in the form of opinion columns. The study concluded by limiting the finding to the fact that online news media have more possibility than the conventional news media to perform the fundamental role of shaping and leading the public opinion by providing the diversity of news to audience.
Query by example (1975)

In the last few years we have witnessed a trend to appeal to the non-professional user who has little or virtually no computer or mathematical background.
Surface visualisation of tissue interfaces by scanning electron microscopy. Methods for exposure of the basal lamina and associated structures in human amnion. (1988)

Tissue interfaces such as basal lamina have been traditionally investigated in transmission electron microscopy by sections cut vertical to the lamina, presenting information restricted to a single ultrathin plane. In order to overcome this limitation, a methodology for surface visualisation of the underside cell membranes of the amniotic epithelium, the upper and lower basal lamina surfaces, and their relationship to the stromal collagen has been devised. This involves alkaline, detergent or enzymatic loosening and/or removal of the epithelial monolayer prior to fixation, followed by dry fracture after critical point drying. In this way we have visualised large areas of all interfaces and the inter-relationships between these elements during the process of stromal collagen production by the amniotic epithelial cells.
A crosslinked fullerene matrix doped with an ionic fullerene as a cathodic buffer layer toward high-performance and thermally stable polymer and organic metallohalide perovskite solar cells (2015)

In this study, we developed a new cathodic buffer layer consisting of a cross-linked [6,6]-phenyl-C<sub>61</sub>-butyric styryl dendron ester (C-PCBSD) matrix and an ionic FPI dopant.
Pilot production and advanced development of large-area picosecond photodetectors (2016)

We report pilot production and advanced development performance results achieved for Large Area Picosecond Photodetectors (LAPPD). The LAPPD is a microchannel plate (MCP) based photodetector, capable of imaging with single-photon sensitivity at high spatial and temporal resolutions in a hermetic package with an active area of 400 square centimeters. In December 2015, Incom Inc. completed installation of equipment and facilities for demonstration of early stage pilot production of LAPPD. Initial fabrication trials commenced in January 2016. The “baseline” LAPPD employs an all-glass hermetic package with top and bottom plates and sidewalls made of borosilicate float glass. Signals are generated by a bi-alkali Na<sub>2</sub>KSb photocathode and amplified with a stacked chevron pair of “next generation” MCPs produced by applying resistive and emissive atomic layer deposition coatings to borosilicate glass capillary array (GCA) substrates. Signals are collected on RF strip-line anodes applied to the bottom plates which exit the detector via pinfree hermetic seals under the side walls. Prior tests show that LAPPDs have electron gains greater than 107, submillimeter space resolution for large pulses and several mm for single photons, time resolutions of 50 picoseconds for single photons, predicted resolution of less than 5 picoseconds for large pulses, high stability versus charge extraction, and good uniformity. LAPPD performance results for product produced during the first half of 2016 will be reviewed. Recent advances in the development of LAPPD will also be reviewed, as the baseline design is adapted to meet the requirements for a wide range of emerging application. These include a novel ceramic package design, ALD coated MCPs optimized to have a low temperature coefficient of resistance (TCR) and further advances to adapt the LAPPD for cryogenic applications using Liquid Argon (LAr). These developments will meet the needs for DOE-supported RD for the Deep Underground Neutrino Experiment (DUNE), nuclear physics applications such as EIC, medical, homeland security and astronomical applications for direct and indirect photon detection.
Rapid non-invasive temperature measurement of complex Si structures using (1998)

Use of spectroscopic ellipsometry for temperature monitoring of complex Si structures is discussed. System calibration is demonstrated for Si epitaxy between 610 °C and 850 °C on our growth system and shown to be in reasonable agreement with reference data in the literature. Use of virtual interface analysis of spectroscopic ellipsometry spectra is shown to allow an emittance-free determination of wafer temperature during growth on complex silicon-on-insulator substrates and highlights the large errors obtained from the corresponding pyrometer measurement. Measurement of emittance using spectroscopic ellipsometry to correct the pyrometer values is shown to be feasible. Accurate realisation of epitaxial designs is obtained using spectroscopic ellipsometry to end-point thicknesses of epitaxial layers and differential techniques are introduced as a potentially more accurate and absolute source of temperature values.
Hepatitis C, other types of non-B parenteral hepatitis and blood transfusion. (1993)

Since the implementation of sensitive screening tests for hepatitis B virus infection, the majority of post-transfusion hepatitis has been due to infection with hepatitis C virus (HCV). The recent introduction of tests for antibodies to this virus has demonstrably reduced the incidence of post-transfusion HCV infection. There is some residual post-transfusion and sporadic hepatitis, which may possibly be caused by an as yet undescribed aetiologic agent. However, evidence for or against such an agent is by no means definitive. The majority of cases of this residual hepatitis seem to be mild and progression to chronicity is less frequent than for HCV infection. There is no evidence to suggest that modern, fully inactivated pooled plasma products transmit this poorly characterized form of hepatitis. However, in some circumstances, the potential for transmission of non-enveloped viruses by clotting factors may persist.
Vasospasm and p53-Induced Apoptosis in an Experimental Model of Subarachnoid Hemorrhage (2006)

Apoptosis, and in particular p53, may play an important role in the etiology of vasospasm with relation to SAH, and in this model, vasospasm persisted to 72 hours, despite the fact that apoptosis does not.
Network Coding Scheme Based on LDPC Product Codes in Multiple-Access Relay System (2011)

In this paper, we consider a multiple-access relay system with two users, one relay, and one destination. The relay combines the data packets received from these two users and then forwards the data packets to the destination. We consider a novel network coding scheme for information combing at the relay, namely, Low-density parity-check (LDPC) product coding. For LDPC product codes, we propose a joint iterative channel decoding (JICD) scheme based on bipartite graph under the log-likelihood ratio belief propagation (LLR-BP) algorithm resist the interference and fading at the destination. Simulation results show that the packet-error-ratio (PER) performance of LDPC product codes based network coding scheme outperforms the traditional XOR-operation based network coding scheme.
The Angiopoietin/Tie-2 System Regulates Pericyte Survival and Recruitment in Diabetic Retinopathy (2008)

These findings demonstrate that Tie-2 is functional in pericytes and may play an important role in the progression of diabetic retinopathy, by regulating pericyte loss and influencing the activation state and recruitment of pericytes.
Physical Characterization of Coupled Poly(lactic acid)/Starch/Maleic Anhydride Blends Plasticized by Acetyl Triethyl Citrate (2004)

Acetyl triethyl citrate (ATC) was used as a plasticizer for poly(lactic acid) (PLA)/starch blends coupled with maleic anhydride and an initiator of 2,5-bis(tert-butylperoxy)-2,5-dimethylhexane (L101). Elongation of the blend at break was markedly increased when the ATC content was above the 8% loading level, which is referred to as the percolation threshold. The extended elongation was achieved at the expense of tensile strength and elastic modulus. Thermal transitions of the blend, including the glass transition temperature (T(g)), cold crystallization temperature (T(c)) and melting temperature (T(m)), decreased with ATC content. Thermally induced ATC migration affected the thermal behavior of the plasticized blends and reduced elongation and tensile strength, whereas the elasticity modulus increased. ATC migration increased with ambient temperature, which was controlled by the activation energy of the blend system. Leaching of ATC was slow at room temperature in distilled water, but significant in boiling water. Additionally, the leaching rate was also directly proportional to the ATC content of the blend. Glass transition temperatures of PLA/starch/MA/L101 blends with various acetryl triethyl citrate contents.
Discovery of Highly Potent Small Molecule Kallikrein Inhibitors (2006)

Uncontrolled kallikrein activation is involved in diseases such as hereditary angioedema, bacterial septic shock and procedures such as cardiopulmonary bypass. Here we report a series of small molecule compounds that potently inhibit kallikrein activity in vitro. Kinetic studies indicate that some of these compounds are slow binding inhibitors of kallikrein with Ki final less than a nanomolar. The ability of these compounds to inhibit the activity of kallikrein was further confirmed in a plasma model by quantitating the release of bradykinin, an endogenous cleavage product of plasma kallikrein. To understand the inhibitory mechanism of the selected compounds toward kallikrein, the interactions between the selected compounds and kallikrein was explored using molecular modeling based on the information of crystal structures of TF/FVIIa and kallikrein. The information presented in the current study provides an initial approach to develop more selective and therapeutically useful small molecule inhibitors.
Low Temperature Mechanical Testing of Carbon-Fiber/Epoxy-Resin Composite Materials (1996)

The use of cryogenic fuels (liquid oxygen and liquid hydrogen) in current space transportation vehicles, in combination with the proposed use of composite materials in such applications, requires an understanding of how such materials behave at cryogenic temperatures. In this investigation, tensile intralaminar shear tests were performed at room, dry ice, and liquid nitrogen temperatures to evaluate the effect of temperature on the mechanical response of the IM7/8551-7 carbon-fiber/epoxy-resin system. Quasi-isotropic lay-ups were also tested to represent a more realistic lay-up. It was found that the matrix became both increasingly resistant to microcracking and stiffer with decreasing temperature. A marginal increase in matrix shear strength with decreasing temperature was also observed. Temperature did not appear to affect the integrity of the fiber-matrix bond.