gebhart/patrepeval huggingface dataset:
Kinesio<sup>®</sup>Taping in Stroke: Improving Functional Use of the Upper Extremity in Hemiplegia (2006)

The purpose of this article is to present the Kinesio taping method used to improve the upper extremity function in the adult with hemiplegia. The article discusses various therapeutic methods used in the treatment of stroke patients to achieve a functional upper extremity. The only taping technique for various upper extremity conditions that has been described in the literature is the athletic taping technique. In this article, some interpretation is offered on proper assessment of the nonfunctional upper extremity, including the emphasis on postural alignment, trunk control, and scapula alignment. The Kinesio taping method in conjunction with other therapeutic interventions may facilitate or inhibit muscle function, support joint structure, reduce pain, and provide proprioceptive feedback to achieve and maintain preferred body alignment. Restoring trunk and scapula alignment after the stroke is critical in an effective treatment program for the upper extremity in hemiplegia.
ChemInform Abstract: Metal‐Cation‐Directed Synthesis, Structures, and Optical Properties of Mo(W)/S(Se)/Ag Clusters: A Brief Overview (2013)

Abstract Review: 38 refs.
A Novel Aryl Migration from Silicon to Carbon:  An Efficient Approach to Asymmetric Synthesis of α-Aryl β-Hydroxy Cyclic Amines and Silanols (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Novel Aryl Migration from Silicon to Carbon: An Efficient Approach to Asymmetric Synthesis of α-Aryl β-Hydroxy Cyclic Amines and SilanolsKatsuhiko Tomooka, Atsuo Nakazaki, and Takeshi NakaiView Author Information Department of Applied Chemistry Tokyo Institute of Technology Meguro-ku, Tokyo 152-8552, Japan Cite this: J. Am. Chem. Soc. 2000, 122, 2, 408–409Publication Date (Web):December 31, 1999Publication History Received13 September 1999Published online31 December 1999Published inissue 1 January 2000https://pubs.acs.org/doi/10.1021/ja993295thttps://doi.org/10.1021/ja993295trapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views3018Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information SUBJECTS:Alcohols,Amines,Genetics,Pharmaceuticals,Silicon Get e-Alerts
Isolation and Properties of Lysine-producing Mutants with Feedback-resistant Aspartokinase Derived from a<i>Brevibacterium flavum</i>Strain with Citrate Synthase- and Pyruvate Kinase-defects and Feedback-resistant Phosphoenolpyruvate Carboxylase (1990)

Although the growth of Brevibacterium flavum KH-21 with CSL, PK−, and PCR was resistant to a lysine analogue, AEC, plus Thr at a concentration of 1 to 3 g/l, used conventionally for isolation of AKR mutants, it was inhibited by higher concentrations of them, and recovered partially upon the addition of Lys, DAP and Met. The growth level recovered was equal to that in the presence of Thr alone. Several lysine-producing mutants with AKR were isolated as those resistant to these high concentrations of AEC plus Thr. The representative strain, AH-198, produced 51 g/l of Lys · HCl at maximum, when cultured for 72 hr in a medium containing 100 g/l of glucose, while the parent strain KH-21 produced only 2 g/l. The productivity of strain AH-198 was the same as or a little higher than that of the HD− type lysine-producing strain No. 22 with CSL, PK−, and PCR·I0.5, the concentration of Lys and Thr inhibiting 50% of the AK activity was 40 mm, 267-fold that of the parent enzyme. The Km for Asp and the optimum concentration of (NH4)2SO4 for the apparent Vmax were also increased. In addition, the inhibition by Thr or Lys alone disappeared in the mutant enzyme.
3D Audio and Acoustic Environment Modeling (1999)

Recently, there has been a proliferation of... This paper describes the 3D audio and acoustic environment modeling technology developed by Wave Arts, Inc. Wave Arts technology is the result of extensive research and development by Bill Gardner, a graduate of the MIT Media Lab. Dr. Gardner&apos;s research at the Media Lab focussed on the key technologies of 3D audio: binaural synthesis [8,11,13], crosstalk cancellation [9,11-13], and reverberation algorithms [4,5,7,10]. The Wave Arts 3D technology has recently been incorporated into the InMotion 3D Audio Producer software, developed jointly with Human Machine Interfaces, Inc. This paper both gives a...
Power oscillation damping control strategies for FACTS devices using locally measurable quantities (1995)

This paper presents a way to derive power oscillation damping control strategies for flexible AC transmission system (FACTS) devices, and derives these laws for the four major types of FACTS devices using an energy function (Lyapunov) method. All controls rely only on locally measurable information, and are independent of system topology, implying structural uncertainty need not affect power oscillation damping control strategies.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Automatic detection of exonic splicing enhancers (ESEs) using SVMs (2008)

The motif-oriented data-extraction method seems to produce consistent training and test data leading to good classification rates and thus allows verification of potential ESE motifs. The best results were obtained using an SVM with the combined oligo kernel, while oligo kernels with oligomers of a certain length could be used to extract relevant features.
Multi-agent path planning with multiple tasks and distance constraints (2010)

The DPC algorithm developed in our previous work is an efficient way of computing optimal trajectories for multiple robots in a distributed fashion with time-parameterized constraints on the distances between pairs of robots. In the present work we extend DPC to the problem of multiple task execution. While this extended problem inherits all the objectives, complexities and constraints of the basic DPC algorithm, each robot is also given an unordered set of tasks that it has to execute before it reaches its goal. There is no specific order imposed on the tasks assigned to a particular robot. The algorithm decides the order of execution of the tasks such that an optimal solution is attained while the time-parametrized distance constraints are satisfied along with successful execution of the tasks. We solve this problem by designing a “State-task Graph” that represents a product of the state-space graph and the task graph. We then develop an efficient heuristic function for performing searches in this graph.
Discontinuity preserving regularization of inverse visual problems (1994)

The method of Tikhonov regularization has been widely used to form well-posed inverse problems in low-level vision. The application of this technique usually results in a least squares approximation or a spline fitting of the parameter of interest. This is often adequate for estimating smooth parameter fields. However, when the parameter of interest has discontinuities the estimate formed by this technique will smooth over the discontinuities. Several techniques have been introduced to modify the regularization process to incorporate discontinuities. Many of these approaches however, will themselves be ill-posed or ill-conditioned. This paper presents a technique for incorporating discontinuities into the reconstruction problem while maintaining a well-posed and well-conditioned problem statement. The resulting computational problem is a convex functional minimization problem. This method is compared to previous approaches and examples are presented for the problems of reconstructing curves and surfaces with discontinuities and for estimating image data. Computational issues arising in both analog and digital implementations are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Structural Dynamics and Thermostabilization of Neurotensin Receptor 1 (2015)

The neurotensin receptor NTSR1 binds the peptide agonist neurotensin (NTS) and signals preferentially via the Gq protein. Recently, Grisshammer and co-workers reported the crystal structure of a thermostable mutant NTSR1-GW5 with NTS bound. Understanding how the mutations thermostabilize the structure would allow efficient design of thermostable mutant GPCRs for protein purification, and subsequent biophysical studies. Using microsecond scale molecular dynamics simulations (4 μs) of the thermostable mutant NTSR1-GW5 and wild type NTSR1, we have elucidated the structural and energetic factors that affect the thermostability and dynamics of NTSR1. The thermostable mutant NTSR1-GW5 is found to be less flexible and less dynamic than the wild type NTSR1. The point mutations confer thermostability by improving the interhelical hydrogen bonds, hydrophobic packing, and receptor interactions with the lipid bilayer, especially in the intracellular regions. During MD, NTSR1-GW5 becomes more hydrated compared to wild type NTSR1, with tight hydrogen bonded water clusters within the transmembrane core of the receptor, thus providing evidence that water plays an important role in improving helical packing in the thermostable mutant. Our studies provide valuable insights into the stability and functioning of NTSR1 that will be useful in future design of thermostable mutants of other peptide GPCRs.
Photochemical preparation of a stable oxetene (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical preparation of a stable oxeteneLouis E. Friedrich and Gary B. SchusterCite this: J. Am. Chem. Soc. 1969, 91, 25, 7204–7205Publication Date (Print):December 1, 1969Publication History Published online1 May 2002Published inissue 1 December 1969https://doi.org/10.1021/ja01053a061RIGHTS & PERMISSIONSArticle Views172Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (262 KB) Get e-Alerts Get e-Alerts
Synthesis of Multi‐1,10‐phenanthroline Ligands with 1,3‐Phenylene Linkers and Their Lithium Complexes (2005)

The synthesis of two multisite ligands containing four and five 1,10-phenanthroline (phen) chelates in line, respectively, is presented. The connectors are 1,3-phenylene linkers. The two ligands were prepared following multistep procedures, the two key reactions being the Suzuki coupling reaction between aromatic nuclei and the nucleophilic addition of aryllithium derivatives onto a phen fragment. The coordination chemistry of both ligands with Li+ ions was very clean and selective, whereas their reaction with copper(I) led to intractable mixtures of insoluble complexes. The tetraphen and the pentaphen compounds afforded almost quantitatively the four- and five-lithium double-stranded helical complexes, respectively. The helical systems are probably highly wound, as indicated by NMR measurements. The pronounced strain of the 5-Li+ complex is reflected by the easy loss of a lithium cation, as shown by electrospray mass spectrometry.
The Melbourne Water river health drought response: Identifying and managing refuge for fish and other biota (2010)

Melbourne Water is the caretaker of river health for more than 8,400 km of rivers and creeks in the Port Phillip and Westernport region of Melbourne. Southeastern Australia has experienced 13 years of below average rainfall and this has placed additional pressures on already-stressed aquatic fauna. In intermittently flowing waterways, aquatic habitats fragment into a series of discrete pools during cease-to-flow periods. Climate change projections suggest that the frequency, magnitude and duration of cease-to-flow periods will change, with complete loss of surface water already realised in some of our streams. When these forecasts are extrapolated to fish distributions, results indicate that species distributions will contract and in some cases we will experience a complete loss of some species from certain waterways in the Melbourne Water region. A key challenge for natural resource managers is anticipating potential climate change impacts on waterway health and to place these impacts in the context of existing pressures on waterways as adaptation plans become incorporated into management actions. Here we discuss Melbourne Water's response to date (2007-2010) in managing observed impacts of prolonged drought conditions on river health values (in particular threatened fish species and platypus). This paper presents Melbourne Water's planning response to these challenges and describes the regional-scale process undertaken to identify priority river health values and refuge pools. This is followed by an overview of the Melbourne Water and Healthy Waterways Waterwatch Program's drought refuge monitoring program and then a presentation of three case studies where emergency management responses have subsequently been enacted. Finally, lessons learnt from Melbourne Water's drought refuge response and management to date are shared, with consideration given to the broader response to climate change.
Abstract 3138: Mechanism based quality control (MBQC) for the four-herb Chinese medicine formulation, PHY906(YIV-906) and other herbal products (2017)

Abstract PHY906(YIV-906), a four-herb Chinese medicine formulation, is inspired by an 1800 year-old Chinese formulation called Huang Qin Tang historically used to treat gastrointestinal symptoms. PHY906 can increase the anti-tumor activity of immunotherapy antibodies or chemotherapies while promoting damaged intestinal tissue recovery. Several clinical studies showed that PHY906 had potential to increase the therapeutic index of cancer treatments (chemotherapy, radiation) by prolonging life and improving patient quality of life. When in vivo activities of three different clinical batches (number 6, 10, 11) of PHY906 and F (which is commercial batch of Huang Qin Tang, HQT) was compared to their similarity of chemical profiles, the two set results could not be completely matched. For example, F had very different in vivo activities from PHY906-10 but F clustered closely to PHY906-10 based on their chemical profiles. This information concludes that chemical profile analysis without excluding irrelevant chemicals is not sufficient to evaluate the in vivo activities of a polychemcial mixture. Therefore, we included another two biological platforms based on the in vivo mechanism of action of PHY906 for the quality control. First, we tested the activity of different batches of PHY906 and F on our signaling transduction activity response (STAR) platform which including 18 luciferase reporter cell lines and 2 enzymatic assays. The results of correlation analysis and clustering analysis based on the results from STAR could be matched to in vivo activities of different batches of PHY906 and F. Second, we tested the effect of different batches of PHY906 and F on a set of genes which based on our previous DNA array data in cell culture and the mechanism action of PHY906. Again, the results of correlation analysis and clustering analysis based on qRT-PCR could be matched to to in vivo activities of PHY906 and F. In conclusion, the quality control of a herbal product should be dependent on its usage. Appropriate biological assays based on its mechanism action should be developed for QC for particular usage. Chemical fingerprint has limitation unless irrelevant chemicals had been filter out. Similarity index is only useful when relevant information is used. Mechanism based quality control could be used for other herbal products. This work was supported by grant (1PO1CA154295-01A1) from National Cancer Institute (NCI), NIH, USA. Dr. Yung-Chi Cheng is a fellow of National Foundation for Cancer Research (NFCR), USA. Citation Format: Wing Lam, Yongshen Ren, Fulan Guan, Zaoli jiang, William Cheng, Shwu-Huey Liu, YungChi Cheng. Mechanism based quality control (MBQC) for the four-herb Chinese medicine formulation, PHY906(YIV-906) and other herbal products [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3138. doi:10.1158/1538-7445.AM2017-3138
Human immune recognition-based multicomponent subunit vaccines against tuberculosis (2005)

The cell-mediated immune response, with its shift in favour of type-1 over type-2 T-helper cell immune response, is generally regarded as essential to protection against mycobacterial infections. The aim of this study was to evaluate the protective potential of two multicomponent subunit vaccines (MSV-1 and MSV-2) against tuberculosis (TB) based on human immune recognition. MSV-1 consisted of five immunodominant antigens (TB10.4, early secretory antigenic target (ESAT)-6, culture filtrate protein (CFP)-8, CFP-10 and CFP-15) selected from a group of polypeptides, which induced a predominant T-cell response in immune human subjects, whereas MSV-2 consisted of antigens (CFP-11, CFP-21, CFP-22.5, Mycobacterium tuberculosis protein (MPT)-64 and CFP-31) selected from a group of polypeptides which induced a subdominant T-cell response along with the antibody response. Both of these sets of polypeptides were extensively recognised in healthy individuals with significant interferon gamma release compared to the diseased population. In C57BL/6J mice, at the level of the lungs, the order of protective efficacy for the test vaccines was: bacille Calmette-Guerin (BCG)>MSV-2>MSV-1. The protective efficacy of MSV-1 was found to be significantly less than that of MSV-2 and BCG at the level of spleen, whereas that of MSV-2 was comparable to that of BCG. The results of this study indicate that high T-helper cell type 1 response-inducing polypeptides selected on the basis of human immune recognition do not necessarily impart protection during vaccination experiments.
Treatment of autoimmune diseases through manipulation of antigen presentation. (1997)

In rheumatoid arthritis, HLA-DR alleles associated with elevated relative risk share a common sequence in the third hypervariable domain of the major histocompatibility complex class II molecule (MHC II). Immunization of mice with a peptide vaccine comprised of the appropriate MHC II sequence in adjuvant blocked the onset and reduced the relapse rate of experimental autoimmune encephalomyelitis (EAE). A phase I clinical trial testing a single injection of a third hypervariable domain peptide from the HLA-DRB1*0401 sequence in alum adjuvant showed that the vaccine is well tolerated and generates an anti-HLA-DR antibody response in approximately 25% of the treated patients. A phase II trial testing multiple boosts is in progress. In a more antigen-specific approach, solubilized MHC II molecules loaded with an autoantigenic peptide are injected intravenously to induce unresponsiveness by the binding of the T-cell receptor (TCR) in the absence of costimulation. Appropriate soluble MHC II:autoantigenic peptide complexes inhibit the recall antigen proliferative response of T clones or draining lymph node cells, and reduce the progression of EAE and experimental autoimmune myasthenia gravis (EAMG). A test of a soluble HLA-DR2:myelin basic protein (MBP) complex in multiple sclerosis is progressing in phase I.
Characterizing the Size and Molecular Weight Distribution of Starch: Why It Is Important and Why It Is Hard (2010)

International audience
Combined p53 and MDM2 biomarker analysis shows a unique pattern of expression associated with poor prognosis in patients with renal cell carcinoma undergoing radical nephrectomy (2011)

Coexpression of p53/MDM2 identifies a subset of patients with poor prognosis, despite all of them having organ-confined disease. Up-regulated p53 is typically wild-type and thus provides a mechanistic explanation for the association between p53 and MDM2 expression: up-regulated wild-type p53 likely promotes the observed MDM2 coexpression. The results obtained in the present study suggest that the p53 pathway is altered in a tissue/disease-specific manner and that therapeutic strategies targeting this pathway should be investigated to determine whether the tumour suppressive function of p53 can be rescued in RCC.
Homogeneity of Phospholipase C of Bovine Uterus and Seminal Vesicle Compared with Brain Isozymes (1988)

Phosphoinositide-specific phospholipase C(PI-PLC) is a second messenger of signal transducer on cell membrane. In the previous study, PLC of bovine brain has been purified three isozymes. In this paper, uterus and seminal vesicle have been purified. Two peaks of PI-PLC activity were resolved when bovine uterus and seminal vesicle proteins were chromatographed on a DEAE and phenyl TSK 5PW HPLC column. Each two peak was compared with PI-PLC I, IT and ill from bovine brain and we got the retension time on HPLC. The peak fractions with PLC activity were tested homogeneity with brain PLC monoclonal antibodies(Mab). Mab-labeled affigels were bounded in the range of 73.8%~97.5% with PLC I, IT and III. Homogeneity of fractions were revealed that DEAE F-1 and phenyl F-1-I were highest level of PLC III in uterus and seminal vesicle and DEAE F-2 and phenyl F-2-I were mixed PLC I and II.