gebhart/patrepeval huggingface dataset:
Mechanisms for Inhibition of the Generation of Thrombin Activity by Sulfated Polysaccharides<sup>a</sup> (1986)

Three mechanisms by which sulfated polysaccharides act as anticoagulants and possibly as antithrombotic agents have been described. These are the two heparin cofactor-dependent mechanisms involving the catalysis of the inhibition of various proteases of coagulation by either antithrombin III or heparin cofactor II. The third is a heparin cofactor-independent mechanism involving the inhibition of formation of prothrombinase and tenase complexes. Four sulfated polysaccharides previously shown to have anticoagulant and antithrombotic effects were assessed to determine which of the three mechanisms operate in the expression of their anticoagulant effects. To do this, [125I]prothrombin was added to undiluted human plasma, and the inhibition of [125I]prothrombin activation, or the catalysis of the formation of thrombin-inhibitor complexes was determined in plasma containing one of the four sulfated polysaccharides. Prothrombin activation was demonstrated by the formation of [125I]prothrombin fragment 1.2 and [125I]thrombin. The effect of the thrombin-specific inhibitor, D-Phe-L-Pro-L-ArgCH2Cl (PPACK), on prothrombin activation was also investigated to determine the role of thrombin-dependent feedback reactions on efficient prothrombin activation. Use of PPACK with sulfated polysaccharides also facilitated estimation of the role of the heparin cofactor-independent effects of sulfated polysaccharides on prothrombin activation. Three concentrations of each of the sulfated polysaccharides were used: 0.66, 6.6, and 66 micrograms/ml of plasma. PPACK (1.0 X 10(-6)M) completely inhibited both intrinsic and extrinsic prothrombin activation. The inhibition of prothrombin activation caused by PPACK was abolished when thrombin was added to the plasma before PPACK. These observations indicate that the presence of trace thrombin activity is critical for efficient prothrombin activation by both the intrinsic and extrinsic pathways. All three concentrations of standard heparin completely inhibited the intrinsic activation of prothrombin. This inhibition was only partially abolished when thrombin was added to the plasma before heparin, indicating that heparin inhibits prothrombin activation both by catalyzing the inhibition of thrombin activity and by a heparin cofactor-independent mechanism. Heparan sulfate did not inhibit intrinsic prothrombin activation but catalyzed the inhibition of the thrombin generated by the formation of thrombin-antithrombin III complex. Dematan sulfate inhibited intrinsic prothrombin activation only at the highest concentration. At the two lower concentrations, dermatan sulfate catalyzed formation of thrombin-heparin cofactor II.(ABSTRACT TRUNCATED AT 400 WORDS)
Idiopathic Hirsutism* (2000)

Hirsutism, the presence of terminal (coarse) hairs in females in a male-like pattern, affects between 5% and 10% of women. Of the sex steroids, androgens are the most important in determining the type and distribution of hairs over the human body. Under the influence of androgens hair follicles that are producing vellus-type hairs can be stimulated to begin producing terminal hairs (i.e., terminalized). The activity of local 5alpha-reductase (5alpha-RA) determines to a great extent the production of dihydrotestosterone (DHT), and consequently the effect of androgens on hair follicles. While there are two distinct 5alpha-RA isoenzymes, type 1 and type 2, the activity of these in the facial or abdominal skin of hirsute women remains to be determined. Although the definition of idiopathic hirsutism (IH) has been an evolving process, the diagnosis of IH should be applied only to hirsute patients with normal ovulatory function and circulating androgen levels. A history of regular menses is not sufficient to exclude ovulatory dysfunction, since up to 40% of eumenorrheic hirsute women are anovulatory. The diagnosis of IH, when strictly defined, will include less than 20% of all hirsute women. The pathophysiology of IH is presumed to be a primary increase in skin 5alpha-RA activity, probably of both isoenzyme types, and possibly an alteration in androgen receptor function. Therapeutically, these patients respond to antiandrogen or 5alpha-RA inhibitor therapy. Pharmacological suppression of ovarian or adrenal androgen secretion may be of additional, albeit limited, benefit. New therapeutic strategies such as laser epilation or the use of new biological response modifiers may play an important role in offering a more effective means of treatment to remove unwanted hair. Further investigations into the genetic, molecular, and metabolic aspects of this disorder, including only well defined patients, are needed.
Digitizing immunoassay on an antibody nanoarray to improve assay sensitivity (2013)

Immunoassays are routine tests used to quantify proteins in biological samples, such as blood or serum. An important challenge to early diagnosis of diseases is the detection of biomarkers at ultra-low concentration, which requires ultra sensitivity assays. Here, we using a novel lift-off nanocontact printing technique to produce a large-scale antibody nanoarray (ANA), and use this array to perform sandwich assays. The sandwich format ensures the high specificity and the nanoarray (NA) allows us to digitize the assay results by counting the binding events discretely. We show that the digitization of immunoassays improves assay sensitivity.
Longterm noninvasive ventilation in children and adolescents with neuromuscular disorders (2003)

The aim of the current study was to investigate the long-term impact of nocturnal noninvasive (positive-pressure) ventilation (NIV) on sleep, sleep-disordered breathing (SDB) and respiratory function in children and adolescents with progressive neuromuscular disorders (NMD). Thirty patients (12.3 +/- 4.1 yrs) with various inherited NMD were treated with NIV for ventilatory insufficiency (n=14) or symptomatic SDB (n=16). Patients were prospectively followed with sleep studies, spirometry and peak inspiratory muscle pressure. Ten patients were studied before and after 3 nights withdrawal from NIV. NIV normalised nocturnal gas exchange in all patients and diurnal gas exchange in patients with ventilatory insufficiency. The effects persisted over 25.3 +/- 12.7 months. Nocturnal transcutaneous partial pressure of carbon dioxide improved from (baseline versus latest control) 7.1 +/- 1.3 to 5.5 +/- 0.6 kPa (53.7 +/- 9.9 to 41.6 +/- 4.8 mmHg), diurnal carbon dioxide arterial tension from 6.3 +/- 1.6 to 5.4 +/- 0.5 kPa (47.5 +/- 11.9 to 40.6 +/- 3.6 mmHg). NIV improved respiratory disturbance index, arousals from sleep, nocturnal heart rate and sleep architecture. Vital capacity decreased in five adolescents with Duchenne muscular dystrophy -183 +/- 111 mL x yr(-1) but remained stable in 25 children with other conditions (8 +/- 78 mL x yr(-1)). Three nights withdrawal of NIV in 10 previously stable patients resulted in prompt deterioration of SDB and gas exchange back to baseline but could be instantly normalised by resumption of NIV. Noninvasive (positive-pressure) ventilation has favourable long-term impact on nocturnal and diurnal gas exchange and sleep and in patients with non-Duchenne neuromuscular disorders on vital capacity as well. It is indicated in children and adolescents with symptomatic sleep-disordered breathing or ventilatory insufficiency due to neuromuscular disorders.
N-dimensional probability density function transfer and its application to color transfer (2005)

This article proposes an original method to estimate a continuous transformation that maps one N-dimensional distribution to another. The method is iterative, non-linear, and is shown to converge. Only 1D marginal distribution is used in the estimation process, hence involving low computation costs. As an illustration this mapping is applied to color transfer between two images of different contents. The paper also serves as a central focal point for collecting together the research activity in this area and relating it to the important problem of automated color grading
Experiences of implementation using advanced intelligent network release 1 architecture (1992)

Logica Space and Communications Ltd., as sub-contractors to ICL Data Finland are implementing the SCP and SMS part of intelligent network services for Telecom Finland. The IN system will comprise new generation Nokia DX200 digital exchanges, from Nokia Telecommunications, acting as SSP, together with Tandem service control points (SCPs) and service management system (SMS). The architecture used is in accordance with the Bellcore advanced intelligent network, (AIN) release 1 architecture. The system for Telecom Finland is believed to be the first of its kind in the world (using the AIN release 1 architecture), and is expected to be operational by the end of 1992. In the course of the design and implementation, a number of architectural issues have been identified. From his experience in using the new AIN architecture, the author describes some key issues and the solutions that have been adopted. These are: feature interaction rules to cater for when more than one IN feature is invoked for the same call; IN features which continue for an extended period; provision of mechanisms to allow the caller to interrupt the progress of a call-recall facility; and database integrity over multiple SCPs when updates are made directly at an SCP such as for a 'follow-me' service.
CXCR2/CXCR2 Ligand Biology during Lung Transplant Ischemia-Reperfusion Injury (2005)

Lung transplantation is a therapeutic option for a number of end-stage pulmonary disorders. Early lung allograft dysfunction (ischemia-reperfusion injury) continues to be the most common cause of early mortality after lung transplantation and a significant risk factor for the development of bronchiolitis obliterans syndrome. Ischemia-reperfusion injury is characterized histopathologically by lung edema and a neutrophil predominate leukocyte extravasation. The specific mechanism(s) that recruit leukocytes to the lung during post-lung transplantation ischemia-reperfusion injury have not been fully elucidated. Because the ELR+ CXC chemokines are potent neutrophil chemoattractants, we investigated their role during post-lung transplantation ischemic-reperfusion injury. We found elevated levels of multiple ELR+ CXC chemokines in human bronchoalveolar lavage fluid from patients with ischemia-reperfusion injury. Proof of concept studies using a rat orthotopic lung transplantation model of "cold" ischemic-reperfusion injury demonstrated an increase in lung graft neutrophil sequestration and injury. In addition, lung expression of CXCL1, CXCL2/3, and their shared receptor CXCR2 paralleled lung neutrophil infiltration and injury. Importantly, inhibition of CXCR2/CXCR2 ligand interactions in vivo led to a marked reduction in lung neutrophil sequestration and graft injury. Taken together these experiments support the notion that increased expression of ELR+ CXC chemokines and their interaction with CXCR2 plays an important role in the pathogenesis of post-lung transplantation cold ischemia-reperfusion injury.
An ABC of near Infrared Photon Migration in Tissues: The Diffusive Regime of Propagation (2012)

In this paper, the theories commonly used for the study of photon migration through biological tissues and for biomedical applications are reviewed. The concepts of absorption and scattering are introduced with particular reference to biological tissues and to the near infrared wavelength range. In particular, the basic definitions of optical properties and their statistical meaning, the Beer–Lambert law, the modified Beer–Lambert law, the radiative transfer equation and the diffusion equation are examined and described. The main frame of the theories is provided in the time domain, in the continuous wave domain and in the frequency domain and the principal solutions of the radiative transfer equation and of the diffusion equation are reviewed. The propagation of photons through biological tissue can be accurately described with solutions of the radiative transfer equation, while solutions of the diffusion equation are subjected to intrinsic approximations that limit their range of validity. Whenever the solutions of the diffusion equation provide a sufficiently accurate description of photon migration, we have a diffusive regime of propagation and the media where this happens can be denoted as diffusive as well. A rule to identify the diffusive regime of propagation has been provided. For many biological tissues, the diffusive regime of propagation can be established, even near the source, provided the photons have travelled trajectories with lengths greater than four times the transport mean free path.
Lead acetate precursor based p-i-n perovskite solar cells with enhanced reproducibility and low hysteresis (2015)

p-i-n CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> perovskite solar cells with remarkable reproducibility and very low hysteresis are reported using a lead acetate precursor.
Microcontroller Theory and Applications with the PIC18F (2017)

Rafiquzzaman's Microcontroller Theory and Applications with the PIC 18F has been designed for a one-semester or one-quarter course in microcontrollers taught at the undergraduate level in electrical/computer engineering and computer science departments. The students are expected to have a background in C language and digital logic (both combinational and sequential) design. Practitioners of microcontroller-based applications will find more simplified explanations, together with examples and comparisons considerations, than are found in manufacturers' manuals.
Uses of software in digital image analysis: a forensic report (2010)

Forensic image analysis is required an expertise to interpret the content of an image or the image itself in legal matters. Major sub-disciplines of forensic image analysis with law enforcement applications include photo-grammetry, photographic comparison, content analysis and image authentication. It has wide applications in forensic science range from documenting crime scenes to enhancing faint or indistinct patterns such as partial fingerprints. The process of forensic image analysis can involve several different tasks, regardless of the type of image analysis performed. Through this paper authors have tried to explain these tasks, which are described in to three categories: Image Compression, Image Enhancement & Restoration and Measurement Extraction. With the help of examples like signature comparison, counterfeit currency comparison and foot-wear sole impression using the software Canvas and Corel Draw.
Optically induced bistability in the mobility of a two-dimensional electron gas coupled to a layer of quantum dots (1999)

We report a bistability in the resistance of a GaAs/AlGaAs modulation doped field effect transistor in which a layer of InAs self-organized quantum dots has been grown near the electron channel. Brief optical illumination causes a large, persistent drop in the two-dimensional electron gas (2DEG) resistance which can be recovered by allowing a current to flow through the Schottky gate. We demonstrate that illumination reduces the number of electrons trapped in the quantum dots, lowering their potential and thereby enhancing the 2DEG mobility. This bistability could be the basis of an optical memory or sensitive phototransistor.
THE CORRELATION BETWEEN THE EXPRESSION OF p21~(WAF1) AND bcl -2,EGFR,p53,TGF-β_1 IN BREAST CARCINOMA (2001)

To investigate the p21 WAF1 expression and its relationship with bcl 2, EGFR, p53, TGF β 1 in breast carcinomas. p21 WAF1 , bcl 2, EGFR,p53 and TGF β 1 expression at protein level were determined by S P immunohistochemistry technique in 152 cases of breast cancer. The results showed that the p21 WAF1 expression level was correlated with EGFR (x 2=5.221,p0.05,γ=0.19) and TGF β 1(x 2=4.354,p0.05,γ=0.17),and adversely correlated with bcl 2(x 2=16.475,p0.01,γ= -0.33 ),and negatively correlated with p53(x 2=3.114,p0.05). Conclusion: The bcl 2, EGFR and TGF β 1 expression in breast cancer are probably related to the positive regulating directions of the p21 WAF1 .
Basta de hacer planes; es hora de tomar decisiones (2006)

Las empresas experimentan una clara mejora en su toma de decisiones una vez que dejan atras el modelo de planificacion tradicional, que se rige por el calendario y esta basado en unidades de negocio. Es mas, la nueva estructura del proceso de planificacion garantiza que las decisiones que se toman sean probablemente las mejores posibles, dada la informacion de la que disponen los directivos a la hora de tomarlas.
Heat Transfer in Thermoelectric Materials and Devices (2013)

Solid-state thermoelectric devices are currently used in applications ranging from thermocouple sensors to power generators in space missions, to portable air-conditioners and refrigerators. With the ever-rising demand throughout the world for energy consumption and CO2 reduction, thermoelectric energy conversion has been receiving intensified attention as a potential candidate for waste-heat harvesting as well as for power generation from renewable sources. Efficient thermoelectric energy conversion critically depends on the performance of thermoelectric materials and devices. In this review, we discuss heat transfer in thermoelectric materials and devices, especially phonon engineering to reduce the lattice thermal conductivity of thermoelectric materials, which requires a fundamental understanding of nanoscale heat conduction physics.
A high-performance single-phase AC-DC power factor corrected boost converter for plug in hybrid electric vehicle battery chargers (2010)

In this paper, several conventional plug in hybrid electric vehicle charger front end AC-DC converter topologies are investigated and a new bridgeless interleaved PFC converter is proposed to improve the efficiency and performance. Experimental and simulation results of a prototype boost converter converting universal AC input voltage to 400 V DC at 3.4 kW are given to verify the proof of concept, and analytical work reported in this paper.
Fast unsupervised ego-action learning for first-person sports videos (2011)

Portable high-quality sports cameras (e.g. head or helmet mounted) built for recording dynamic first-person video footage are becoming a common item among many sports enthusiasts. We address the novel task of discovering first-person action categories (which we call ego-actions) which can be useful for such tasks as video indexing and retrieval. In order to learn ego-action categories, we investigate the use of motion-based histograms and unsupervised learning algorithms to quickly cluster video content. Our approach assumes a completely unsupervised scenario, where labeled training videos are not available, videos are not pre-segmented and the number of ego-action categories are unknown. In our proposed framework we show that a stacked Dirichlet process mixture model can be used to automatically learn a motion histogram codebook and the set of ego-action categories. We quantitatively evaluate our approach on both in-house and public YouTube videos and demonstrate robust ego-action categorization across several sports genres. Comparative analysis shows that our approach outperforms other state-of-the-art topic models with respect to both classification accuracy and computational speed. Preliminary results indicate that on average, the categorical content of a 10 minute video sequence can be indexed in under 5 seconds.
Solid-Liquid Equilibria in Mixtures of Non-electrolytes (1958)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTSolid-Liquid Equilibria in Mixtures of Non-electrolytesR. P. Rastogi and K. T. Rama VarmaCite this: J. Phys. Chem. 1958, 62, 6, 641–644Publication Date (Print):June 1, 1958Publication History Published online1 May 2002Published inissue 1 June 1958https://pubs.acs.org/doi/10.1021/j150564a001https://doi.org/10.1021/j150564a001research-articleACS PublicationsRequest reuse permissionsArticle Views182Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Computerized Rain Assessment and Tracking of South Florida Weather Radar Echoes (1975)

Weather radar power can be electronically assessed and digitally quantified within many small “range bins.” The tape recorded output from a radar digitizer linked to the Miami WSR-57 is being processed post hoc by a sequence of computer programs written at the Experimental Meteorology Laboratory. One program assesses radar-derived rainfall rates and total rain volumes over preselected areas and for preselected time periods; another isolates and tracks radar echoes and, while so doing, calculates the rainfall from each echo as it grows, moves, splits, merges, or dies. Sample results are displayed and future applications discussed.
1,2,4-Triazole-3-alanine (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,2,4-Triazole-3-alanineR. G. Jones and C. AinsworthCite this: J. Am. Chem. Soc. 1955, 77, 6, 1538–1540Publication Date (Print):March 1, 1955Publication History Published online1 May 2002Published inissue 1 March 1955https://pubs.acs.org/doi/10.1021/ja01611a040https://doi.org/10.1021/ja01611a040research-articleACS PublicationsRequest reuse permissionsArticle Views1801Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts