gebhart/patrepeval huggingface dataset:
Chemistry and photophysics of mixed cadmium sulfide/mercury sulfide colloids (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry and photophysics of mixed cadmium sulfide/mercury sulfide colloidsA. Haesselbarth, A. Eychmueller, R. Eichberger, M. Giersig, A. Mews, and H. WellerCite this: J. Phys. Chem. 1993, 97, 20, 5333–5340Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/j100122a026https://doi.org/10.1021/j100122a026research-articleACS PublicationsRequest reuse permissionsArticle Views553Altmetric-Citations150LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Microlens coupled interdigital photoconductive switch (2008)

A large-area terahertz emitter based on an interdigital finger electrode photoconductive switch on low-temperature grown GaAs attached to a hexagonal microlens array is demonstrated. The hexagonal arranged microlenses direct the incident IR excitation pulses into specified electrode gaps, resulting in constructive interference in the terahertz far field. Using a Ti:sapphire oscillator running at 80MHz with 150fs pulses, 6.5μmTHz average power at 540mW optical excitation is obtained. The maximum IR-to-terahertz conversion efficiency achieved is ⩾1.35×10−5.
Go go games (2013)

In this paper, we describe the design of a therapeutic video game suite for early elementary children with autism spectrum disorders (ASD). The purpose of this work is to present our hypothesis that games that are both fun and faithful to evidence-based therapies could serve as a mechanism to reduce the gap between the amount of therapy recommended for children with ASD and the amount they receive. We describe our process of creating a suite of games modeled on Pivotal Response Treatment (PRT), a technique known to be effective in educating children with ASD. We also describe early indicators of game engagement and outline planned future work to test the games' efficacy as therapeutic tools.
Accurate method for prediction of atmospheric transmission according to weather (1996)

Path-integrated atmospheric transmittance for visible wavelengths
over a 5.5-km horizontal path is measured using black target
contrast ratio. Measurements of on-line particulate distributions by particulate
measuring system instrumentation (PMS) and of meteorological
parameters are also performed. The extinction coefficients, primarily
scattering, of aerosols are calculated using the PMS data, and those
arising from molecular absorption are calculated by MODTRAN. Both
extinction coefficients—the directly measured path-integrated ones and
those calculated from particulate distribution and meteorological parameters
near the receiver—are compared. Good agreement exists, especially
when relative humidity is low, despite the fact that the second
method involves aerosol size distribution by data collected from only a
single point along the atmospheric path. Disagreement between both
methods under high values of relative humidity can be explained by classification
errors of the PMS instrumentation because of changes in the
index of refraction of particles in a humid environment. Statistical regression
analysis is made relating the measured transmittance values to online
meteorological data. A simple and accurate model is obtained to
predict dependence of the extinction coefficient on weather. The regression
coefficients model shows that other meteorological parameters in
addition to relative humidity are responsible for the changes in the atmospheric
scattering coefficients. This contradicts the MODTRAN and
Kasten-Hanel models for a continental atmosphere, which are based
upon specific types of aerosols rather than a mixture of them.
DPC 4/SMAD 4 in non-pancreatic tumors with frequent LOH 18q21 and in hematological malignancies (1997)

Recently, a novel candidate tumor suppressor gene, DPC 4/SMAD 4, has been implicated in the development of pancreatic cancers. Its location at human chromosome 18q21 prompted us to investigate this gene in a large series of primary tumors located outside the gastrointestinal tract which have been associated with loss of heterozygocity (LOH) at this locus. One hundred and thirty primary solid tumor samples (28 breast, 34 non-small cell lung, and 20 prostate cancers, and 40 osteosarcomas), 32 cell lines as well as 162 leukemia and lymphoma cases were analysed by Southern blotting and PCR-SSCP for deletions and mutations of the DPC 4 gene. In the breast cancer cell line MDA-MB-468, the gene was found to be homozygously deleted. Neither the primary solid tumor samples nor hematological malignancies had detectable abnormalities. Our study suggests that alterations of the DPC 4 gene, unlike in pancreatic cancer, are rare in breast, nonsmall cell lung and prostate cancers, osteosarcomas and hematopoietic malignancies.
In vivo methotrexate kinetics and metabolism in human hematopoietic cells. Clinical significance of methotrexate concentrations in erythrocytes. (1990)

The author has performed in vivo investigations of the methotrexate (MTX) accumulation, kinetics and polyglutamate metabolism in erythrocytes, neutrophils and myeloid bone marrow cells during clinical MTX therapy of patients with acute lymphoblastic leukemia (ALL), non-Hodgkin lymphoma and psoriasis. On the basis of these studies the clinical applicability of monitoring erythrocyte MTX concentrations in children with ALL and adult psoriasis patients have been evaluated. To accomplish this task a set of methods has been developed: 1) An automated enzymatic assay adapted for a centrifugal analyzer was used to measure MTX concentrations between 10 and 60 nmol/l in erythrocytes and serum. 2) For the study of MTX kinetics in myeloid cells, age fractionated erythrocytes and HPLC fractionated methotrexate polyglutamates a sequential radioligand binding assay with a range of 1-8 (and 1-16) nmol/l was employed. 3) Discontinuous Percoll gradients of increasing densities were used to separate myeloid cells and erythrocytes of increasing mean cell age. Declining reticulocyte counts and erythrocyte-aspartate aminotransferase activity were taken as parameters of increasing mean erythrocyte age. 4) In order to study MTX polyglutamate metabolism a high performance liquid chromatography (HPLC) procedure was set up using tetrabutylammonium phosphate in acetonitrile in an automatically generated gradient buffer system. The MTX polyglutamates were separated, and the concentrations determined by the radioligand binding assay. The individual polyglutamates were identified by comparisons with the retention times of MTX polyglutamate standards (MTX-glu1+2+3+4+6+7) which were detected spectrophotometrically at 304 nm. During 24 hour infusions MTX was incorporated predominantly in the proliferating myeloid bone marrow cells before appearing in circulating neutrophils about seven days later. Evidence for MTX incorporation in the erythroid precursors of the bone marrow was provided by demonstrating high MTX content in density fractionated reticulocyte enriched erythrocyte populations. During weekly low dose MTX treatment the erythrocyte MTX concentration reached a constant level (steady state ery-MTX) after 4-6 weeks. MTX concentrations in age fractionated red blood cells and the terminal decline of the ery-MTX and its polyglutamate forms after cessation of MTX administration revealed that maintenance of the steady state ery-MTX depended on three conditions: 1) The amount of MTX added to the circulation via MTX containing reticulocytes. 2) The in vivo efflux of MTX from circulating erythrocytes, and 3) The loss of MTX with age dependent destruction of red blood cells. The in vivo efflux of MTX accounted for a loss of MTX which was 3-4 times greater than the amount that was lost with age dependent erythrocyte destruction.(ABSTRACT TRUNCATED AT 400 WORDS)
Effects of in ovo injection of L-carnitine on hatchability and subsequent broiler performance and slaughter yield (2010)

Effects of in ovo injection of L-carnitine on the hatchability, grow-out performance, and slaughter yield of Ross x Ross 308 broilers from a young breeder flock were determined through 48 d of age. Fertilized eggs were injected in the amnion with L-carnitine (0.5, 2.0, or 8.0 mg dissolved in 100 microL of a commercial diluent) on d 18 of incubation using an automated egg injector. Three control groups (noninjected and injected with or without diluent) were also included. Hatchability and hatch rate of fertilized eggs were assessed. Furthermore, subsequent mortality, BW gain, feed intake per bird, and feed conversion were determined through 46 d posthatch. On d 47, live body, carcass, and abdominal fat pad weights, along with the weights of all major commercial cuts including the thigh, drumstick, wings, and breast muscles, were determined. Individual doses of supplemental L-carnitine had no significant effect on the hatchability or rate of hatch of fertilized eggs; however, significant trends were noted for increased hatchability and length of egg incubation in conjunction with increases in L-carnitine dose. Nevertheless, there were no significant treatment effects on any of the grow-out performance or slaughter yield parameters investigated. In conclusion, although increasing the levels of L-carnitine added to commercial vaccine diluent between 0.5 and 8.0 mg/100 microL for commercial in ovo injection did not significantly influence subsequent broiler grow-out performance or slaughter yield, L-carnitine dosages above those used in this study have the potential for significantly increasing incubation length and hatchability of broiler hatching eggs.
Real-time acquisition and display of flow contrast using speckle variance optical coherence tomography in a graphics processing unit (2014)

In this report, we describe a graphics processing unit (GPU)-accelerated processing platform for real-time acquisition and display of flow contrast images with Fourier domain optical coherence tomography (FDOCT) in mouse and human eyes in vivo. Motion contrast from blood flow is processed using the speckle variance OCT (svOCT) technique, which relies on the acquisition of multiple B-scan frames at the same location and tracking the change of the speckle pattern. Real-time mouse and human retinal imaging using two different custom-built OCT systems with processing and display performed on GPU are presented with an in-depth analysis of performance metrics. The display output included structural OCT data, en face projections of the intensity data, and the svOCT en face projections of retinal microvasculature; these results compare projections with and without speckle variance in the different retinal layers to reveal significant contrast improvements. As a demonstration, videos of real-time svOCT for in vivo human and mouse retinal imaging are included in our results. The capability of performing real-time svOCT imaging of the retinal vasculature may be a useful tool in a clinical environment for monitoring disease-related pathological changes in the microcirculation such as diabetic retinopathy.
Neoglycolipid-Based Oligosaccharide Microarray System: Preparation of NGLs and Their Noncovalent Immobilization on Nitrocellulose-Coated Glass Slides for Microarray Analyses (2011)

Carbohydrate microarrays, since their advent in 2002, are revolutionizing studies of the molecular basis of protein-carbohydrate interactions both in endogenous recognition systems and pathogen-host interactions. We have developed a unique carbohydrate microarray system based on the neoglycolipid (NGL) technology, a well-validated microscale approach for generating lipid-tagged oligosaccharide probes for use in carbohydrate recognition studies. This chapter provides an overview of the principles and key features of the NGL-based oligosaccharide microarrays, and describes in detail the basic techniques - from the preparation of NGL probes to the generation of microarrays using robotic arraying hardware, as well as a general protocol for probing the microarrays with carbohydrate-binding proteins.
Event Driving Based Alarm Correlation Approach by Using Petri Net (2009)

According to practical requirement, this paper puts forward an alarm event correlation approach basing on event driving, which considers the temporal relationship between events, and establishes several Petri net models. The experiment results show that, the approach basing on event driving to select time window can implement the alarm event correlation correctively and effectively for complex network. So the accuracy and efficiency of alarm is improved.
Fatty Acid Synthase Modulates Homeostatic Responses to Myocardial Stress (2011)

Fatty acid synthase (FAS) promotes energy storage through de novo lipogenesis and participates in signaling by the nuclear receptor PPARα in noncardiac tissues. To determine if de novo lipogenesis is relevant to cardiac physiology, we generated and characterized FAS knockout in the myocardium (FASKard) mice. FASKard mice develop normally, manifest normal resting heart function, and have normal cardiac PPARα signaling as well as fatty acid oxidation. However, they decompensate with stress. Most die within 1 h of transverse aortic constriction, probably due to arrhythmia. Voltage clamp measurements of FASKard cardiomyocytes show hyperactivation of L-type calcium channel current that could not be reversed with palmitate supplementation. Of the classic regulators of this current, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) but not protein kinase A signaling is activated in FASKard hearts, and knockdown of FAS in cultured cells activates CaMKII. In addition to being intolerant of the stress of acute pressure, FASKard hearts were also intolerant of the stress of aging, reflected as persistent CaMKII hyperactivation, progression to dilatation, and premature death by ∼1 year of age. CaMKII signaling appears to be pathogenic in FASKard hearts because inhibition of its signaling in vivo rescues mice from early mortality after transverse aortic constriction. FAS was also increased in two mechanistically distinct mouse models of heart failure and in the hearts of humans with end stage cardiomyopathy. These data implicate a novel relationship between FAS and calcium signaling in the heart and suggest that FAS induction in stressed myocardium represents a compensatory response to protect cardiomyocytes from pathological calcium flux.
Macro-by-example: Deriving syntactic transformations from their specifications (1987)

This paper presents two new developments. First, it describes a “macro-by-example” specification language for syntactic abstractions in Lisp and related languages. This specification language allows a more declarative specification of macros than conventional macro facilities do by giving a better treatment of iteration and mapping constructs. Second, it gives a formal semantics for the language and a derivation of a compiler from the semantics. This derivation is a practical application of semantics-directed compiler development methodology.
Neurogenic Hypertension in the Rat (1964)

Several techniques of radical denervation of the sino-aortic depressor areas were tried in order to produce a permanent neurogenic hypertension in the rat. The aortic depressor fibers were interrupted at the neck level by resecting the nerves which usually exhibit baroreceptor activity, namely, isolated aortic nerve, sympathetic, and laryngeal nerves. The carotid sinus was denervated by stripping the carotid bifurcation and painting with phenol. When the carotid bifurcation was resected bilaterally, in a one-stage operation, all rats showed symptoms of cerebral ischemia, dying shortly thereafter. Isolated denervation of the aortic baroreceptors was followed by a transitory hypertension. No changes in preasure were observed when only the carotid sinuses were denervated. A few rats in which the usual baroreceptor pathways were interrupted, except the superior laryngeal nerve, developed chronic hypertension. Yet, to obtain consistently permanent hypertension it was necessary to include in the denervation every baroreceptor route. A simple one-stage operation for complete sino-aortic baroreceptor denervation is described. This procedure was used in 140 rats that were then studied for periods up to one year. All the operated animals presented some degree of hypertension. Blood pressure measurements made during the first week showed even then that the rats were hypertensive. This observation suggests that in the rat no latent period for the appearance of neurogenic hypertension is present. Hypertension was permanent in 75% of the rats observed up to one year; blood pressure returned to normal values in the remaining 25%, usually after the third month. Extirpation of the adrenal medulla had no effect on the evolution of the hypertension in the denervated rats. Blood pressure was measured repeatedly in unanesthetized rats by tail plethysmography. Pressure values determined by this method, though 10 to 20 mm Hg lower, approximated the mean arterial pressure recorded directly from the femoral artery in normotensive and hypertensive rats. The hypertension in denervated rats included an increase of systolic as well as diastolic pressure. The heart rates of quiet hypertensive rats were within the normal range and, in general, no close correlation was observed between increases in blood pressure and elevations in heart rate. Normal rats have marked fluctuations in both pressure and heart rate when walking or when stimulated; these fluctuations were much greater in the neurogenic hypertensive animals. Moreover, the hypertensive rats showed large oscillations of blood pressure synchronous with respiratory movements particularly when the latter were slower and deeper than normal. The rats seemed to tolerate both the denervation and the hypertension very well. Histological examination of tissues from hypertensive rats showed myocardial hypertrophy and a thickening of the basement membrane of the glomerular capsule. The severity of the latter abnormality was closely associated with the duration of the hypertension.
InGaAs concentrator cells for laser power converters and tandem cells (1993)

In(0.53)Ga(0.47)As N-on-P concentrator cells were made as part of an effort to develop 1.315 micron laser power converters. The 1.315 micron laser power conversion efficiency was estimated as 29.4 percent (at 5.57 W/cm(sup 2)) based on an 86 percent measured external quantum efficiency at 1.315 microns, and a measured open circuit voltage (484 mV), and fill-factor (67 percent) at the equivalent AM0 short-circuit photocurrent (5.07 A/cm(sup 2)). A 13.5 percent percent AMO efficiency was achieved at 89 suns and 25 C. Measured one-sun and 100-sun AMO efficiency, log I-V analysis, and quantum efficiency are presented for InGaAs cells with and without InP windows to passivate the front surface. Windowed cells performed better at concentration than windowless cells. Lattice mismatch between InGaAs epilayers and InP substrate was less than 800 ppm. Theoretical efficiency is estimated for 1.315 microns laser power converters versus the bandgap energy. Adding aluminum to InGaAs to form In(x)Al(y)Ga(1-x-y)As is presented as a way to achieve an optimal bandgap for 1.315 microns laser power conversion.
Systemic isotretinoin treatment modulates patients’ immune response to <i>P. acnes</i> (111.23) (2011)

Abstract Isotretinoin, a pro-drug for retinoic acid, is the only agent that induces a permanent remission of acne, but the mechanism underlying its long-term efficacy is unknown. We hypothesized that modulation of the immune response to the bacterium involved in acne, P.acnes, is key to isotretinoin’s ability to induce long-term or permanent remissions of acne. This study is the first to investigate changes in peripheral immune cells associated with isotretinoin treatment in acne patients in vivo. Peripheral blood samples were obtained from acne patients before starting isotretinoin therapy (baseline) and at 1, 4, 8, and 20 weeks after starting isotretinoin therapy. Monocytes and lymphocytes were isolated, activated in vitro, and analyzed by flow cytometry. Acne patients’ monocytes expressed higher levels of TLR-2 and secreted more IL-1β, IL-6, IL-8, and IL-10 in response to P. acnes than monocytes from normal volunteers. Isotretinoin therapy significantly decreased TLR-2 expression on acne patients’ monocytes compared to their baselines, and this decrease was maintained at six months after the cessation of therapy. Additionally, isotretinoin therapy significantly decreased the secretion of IL-1β, IL-6, IL-8, and IL-10 by untreated and P.acnes-treated monocytes from acne patients compared to baseline. These results suggest that modulation of the immune response to P.acnes may represent one mechanism of isotretinoin’s long-term efficacy.
Leveraging high-level and low-level features for multimedia event detection (2012)

This paper addresses the challenge of Multimedia Event Detection by proposing a novel method for high-level and low-level features fusion based on collective classification. Generally, the method consists of three steps: training a classifier from low-level features; encoding high-level features into graphs; and diffusing the scores on the established graph to obtain the final prediction. The final prediction is derived from multiple graphs each of which corresponds to a high-level feature. The paper investigates two graph construction methods using logarithmic and exponential loss functions, respectively and two collective classification algorithms, i.e. Gibbs sampling and Markov random walk. The theoretical analysis demonstrates that the proposed method converges and is computationally scalable and the empirical analysis on TRECVID 2011 Multimedia Event Detection dataset validates its outstanding performance compared to state-of-the-art methods, with an added benefit of interpretability.
Example applications of the linear adaptive design technique (1989)

Abstract Adaptive controllers can be designed by a variety of different methodologies that have been developed over the past 35 years. However, all these methodologies have one thing in common; they lead to adaptive controllers that are intriniscatly non‐linear in structure. Recently a new, unorthodox approach to the adaptive control problem has been developed. This new methodology leads to a new class of adaptive controllers that, in many cases, are entirely linear and have all‐constant parameters (constant gains). In the present paper this new approach to adaptive control is used to design‘linear adaptive controllers’for two example applications, and the closed‐loop adaptive performance obtained in each case is illustrated by digital simulation tests. These results demonstrate that the new linear adaptive controllers are able to produce a surprisingly high‐degree of adaptation over significant ranges of plant parameter variations and disturbances.