gebhart/patrepeval huggingface dataset:
An automated procedure for measuring biotinidase activity in serum. (1989)

In this automated procedure for quantifying biotinidase activity in human serum, a manual colorimetric method that measures conversion of the enzyme's artificial substrate N-biotinyl p-aminobenzoate was modified for use with a Technicon AutoAnalyzer II. The intra-run replicate precision (CV) was 2.1% and the day-to-day CV was 4.6% for quality-control sera. Results were linearly related to biotinidase activity in serum over the complete range of clinically relevant values, 0.2 to 11.0 U/L. Moreover, results of the automated assay were not significantly different from those of the manual assay. Because the automated procedure is faster and more precise, we recommend it for population-based studies and some screening studies.
The Synthesis of Certain Ketones and α-Substituted β-Diketones Containing Perfluoroalkyl Groups (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of Certain Ketones and α-Substituted β-Diketones Containing Perfluoroalkyl GroupsLloyd B. Barkley and Robert LevineCite this: J. Am. Chem. Soc. 1953, 75, 9, 2059–2063Publication Date (Print):May 1, 1953Publication History Published online1 May 2002Published inissue 1 May 1953https://pubs.acs.org/doi/10.1021/ja01105a011https://doi.org/10.1021/ja01105a011research-articleACS PublicationsRequest reuse permissionsArticle Views289Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An autocrine role for erythropoietin in mouse hematopoietic cell differentiation [published erratum appears in Blood 1992 Jun 15;79(12):3397] (1991)

Erythropoietin (epo) is the primary regulator of the rate of red blood cell formation in mammals. Because it is formed in the kidney and acts on the bone marrow, its action is classically endocrine. We have shown by PCR that marrow cells contain epo mRNA and that antisense oligodeoxynucleotides, to both epo and its receptor, act on multipotent hematopoietic cells to cause a decrease in mixed erythroid:nonerythroid colonies. The antisense oligonucleotides also cause an increase in mixed nonerythroid colonies with no effect on erythroid burst formation. Sense oligonucleotides have no effect. The antisense suppression is not due to adherent cells, cycling late differentiated cells or lymphocytes, and not reversed by exogenous epo. We conclude that normal erythroid differentiation may have an early phase that is dependent on an internal autocrine mechanism involving epo and its receptor.
Increasing the Electrolyte Capacity of Alkaline Zn–Air Fuel Cells by Scavenging Zincate with Ca(OH)<sub>2</sub> (2014)

Abstract The use of calcium hydroxide for scavenging zincate species is demonstrated to be a highly effective approach for increasing the electrolyte capacity and improving the performance of the zinc–air fuel cell system. A fundamental approach is established in this study to quantify the formation of calcium zincate as the product of scavenging and the amount of water compensation necessary for optimal performance. The good agreement between predicted and experimental results proves the validity of the proposed theoretical approach. By applying the results of theoretical predictions, both the electrolyte capacity and the cell longevity have been increased by more than 40 %. It is also found that, using Ca(OH) 2 to scavenge zincate species in concentrated KOH solutions, affects mostly the removal of zincate, rather than ZnO, from the electrolyte, whereas the presence of excess, free, mobile H 2 O plays a key role in dissolving ZnO and forming zincate. The results obtained in this study demonstrate that the proposed approach can widely and effectively be applied to all zinc–air cell systems during their discharge cycle.
An Auto-regulatory Loop between Stress Sensors INrf2 and Nrf2 Controls Their Cellular Abundance (2007)

INrf2:Nrf2 are sensors of chemical/radiation stress. Nrf2 dissociates from INrf2 in response to a stress and translocates in the nucleus. This leads to induction of a battery of antioxidant genes that protect cells. Nrf2 is then exported out and degraded. INrf2 functions as an adaptor of ubiquitin ligase for ubiquitination and degradation of Nrf2. Here we demonstrate the presence of a novel feedback autoregulatory loop between INrf2 and Nrf2 that controls cellular abundance of INrf2 and Nrf2. Nrf2 controls its own degradation by regulating expression and induction of the INrf2 gene. The antioxidant treatment of cells led to nuclear localization and stabilization of Nrf2 and induction of INrf2 gene expression. Mutagenesis, transfection, and chromatin immunoprecipitation assays identified an antioxidant-response element in the reverse strand of the proximal INrf2 promoter that binds to Nrf2 and regulates expression and antioxidant induction of the INrf2 gene. In addition, short interfering RNA inhibition or overexpression of Nrf2 led to a respective decrease and increase in INrf2 gene expression. These results implicated Nrf2 in the regulation of expression and induction of INrf2. The induction of INrf2 followed ubiquitination and degradation of Nrf2 and suppression of INrf2 gene expression. In conclusion, Nrf2 regulates INrf2 by controlling its transcription, and INrf2 controls Nrf2 by degrading it.
A Survey on Human-in-the-Loop Applications Towards an Internet of All (2015)

Our tools and appliances are becoming increasingly more intelligent and interconnected, giving birth to an “Internet of Things” that can be used to support new types of cyber-physical systems (CPSs). While many CPSs are human-centric applications where humans are an essential part of the system, unfortunately, most of these systems still consider the human as an external and unpredictable element to the control loop. In order for these systems to better serve human needs, future CPSs will need to bolster a closer tie with the human element, through Human-in-the-Loop controls that take into consideration human intents, psychological states, emotions and actions inferred through sensory data. This area is a natural confluence of multidisciplinary focus but currently lacks a general understanding of the underlying requirements, principles and theory. As far as we know, this survey is the first effort towards extending the field's knowledge through an in-depth research of the state-of-the-art and a critical overview of the current taxonomic efforts in the area of Human-in-the-Loop CPSs. On top of this research, a novel taxonomic exercise focused on the general roles of the human component together with a requirement analysis, are presented.
Reactions of dimethylphosphono-substituted diazoalkanes. (MeO)2P(O)CR transfer to olefins and 1,3-dipolar additions of (MeO)2P(O)C(N2)R (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of dimethylphosphono-substituted diazoalkanes. (MeO)2P(O)CR transfer to olefins and 1,3-dipolar additions of (MeO)2P(O)C(N2)RDietmar Seyferth, Robert S. Marmor, and Peter HilbertCite this: J. Org. Chem. 1971, 36, 10, 1379–1386Publication Date (Print):May 1, 1971Publication History Published online1 May 2002Published inissue 1 May 1971https://pubs.acs.org/doi/10.1021/jo00809a014https://doi.org/10.1021/jo00809a014research-articleACS PublicationsRequest reuse permissionsArticle Views4227Altmetric-Citations329LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interoperability for geospatial analysis: a semantics and ontology-based approach (2007)

Information extraction and integration from heterogeneous, autonomous data resources are major requirements for many spatial applications. Geospatial analysis for scientific discovery involves identification of relevant information resources, extraction and fusion of requisite subsets of the information, application of spatial analytical techniques and visualization of the results in an appropriate form. The motivating application domain underlying this research is marine environmental management, although the principles discussed apply to a wide range of scientific disciplines. The research discussed in the paper focuses on integration of data sources, data exploration and interactive data analysis. A knowledge base is used to capture the semantics of the spatial, temporal and thematic dimensions at a domain level, and the context-aware framework exploited to meet the requirements of a varied and distributed user community with differing objectives.
Solid State Lighting (2005)

This PDF file contains the editorial “Editorial: Solid State Lighting” for OE Vol. 44 Issue 11
Evaluation of spaghetti supplemented with corn distillers' dried grains (1987)

Spaghettis were prepared supplemented at 5, 10, and 15% levels with corn distillers' grains (CDG) or with CDG extracted with hexane-ethanol azeotrope. Spaghetti containing 10% CDG or 10% extracted CDG had 12-14% more protein and several times the dietary fiber of control sphagetti. Cooked weight, cooking loss and firmness of supplemented spaghettis were acceptable. Sphagettis supplemented with 5 or 10% CDG or extracted CDG had fair flavor and texture quality, but spaghetti containing 15% CDG was unacceptable. These studies demonstrated that acceptable sphagetti can be prepared with up to 10% CDG, thereby improving its nutritional value while providing an additional market for CDG.
A framework managing quality of service contracts in distributed applications (2002)

Designers and implementers of distributed applications have to deal with many difficult problems, such as concurrency control, distributed communication, fault-tolerance, quality of service management. Finding object-oriented solutions to these problems is a very active topic of research and development. Carefully chosen design patterns can help to reverse solutions for distributed application problems. We show how design patterns may allow a designer and developer to manage quality of service issues of distributed object interaction (e.g. when an object invokes a method on another remote object). Interactions between distributed objects (method invocation, remote method execution, result return) may be disturbed by network phenomena such as message losses, variation of transmission latency or bandwidth, link or site crashes. Robust distributed applications must deal with these events in a structured way. We present a contract-based execution framework which helps the application developer in building these mechanisms. To achieve this, we use a reification of the well-known contract notion and provide a set of abstract classes for managing the quality of service. We then describe our framework which provides concrete classes for performing remote method invocations under various distributed execution semantics, e.g. time bounded, atomic execution of a method by a group of objects scattered in the network. As an example of contract based application, we detail the architecture of a distributed interactive virtual space browser built on our framework.
Entecavir Treatment for Up to 5 Years in Patients With Hepatitis B E Antigen–Positive Chronic Hepatitis B (2010)

Extended therapy with entecavir through 5 years maintained or increased rates of HBV DNA suppression and ALT normalization. Additional patients also achieved HBeAg loss and seroconversion. Entecavir provides sustained viral suppression with minimal resistance during long-term treatment of HBeAg-positive CHB.
Legal considerations for nurses practicing in a telehealth setting. (2001)

During the last century the world has become increasingly reliant on a variety of technologies to manage information needs. Escalation in deployment of remote technology to enhance health care, accompanied by expanded public and private reimbursement for distant care, indicates increasing acceptance of these technologies. Yet many legal and regulatory questions regarding the provision of health care using these technologies remain. This article will discuss the foundations of telehealth nursing and address legal and regulatory issues emerging from this new practice modality.
NEBRASKA MODIFIED ROOF POND: 1985 SUMMER PERFORMANCE RESULTS (1985)

This paper reports on the results of three of the tests performed on the Nebraska modified roof pond. During the summer of 1985,? with the test room decoupled from the roof pond itself, several series of tests were initiated. The first experiment (fig. 1) was to test the overall response of the system by forcing the temperature in storage to a preset value and observe its decay/ curve with ponding and spray. The second experiment (fig* 2) was similar to the first but with ponding only and no spray. Experiment three (fig. 3) observed the discharge of heat from pond with the-pump turned off, in essence a natural decay test without roof pond cooling. Net night sky radiation,, ambient air and pond temperatures, and dew point temperature were measured. The water in the roof pond was heated electrically to about 500C and then permitted to cool in various ways. With the pump on in experiments 1 and 2 the convection and evaporation losses were considerably larger than the radiative losses; at the elevated water temperatures the evaporative and convective losses were significantly higher than at the lower water temperatures; the convective-evaporative losses when ponding and ponding with spray are comparable. The losses from the system without active cooling strategies are mainly due to evaporation thru or refluxing in the cracks of the floating insulation and to convection*
In situ distribution of the beta-subunit of platelet-derived growth factor receptor in nonneoplastic tissue and in soft tissue tumors. (1990)

The distribution of the beta-subunit of platelet-derived growth factor receptor (PDGFR-beta) was assessed by a sensitive immunoalkaline phosphatase technique using the monoclonal antibody PR7212. Frozen tissue sections of several nonneoplastic human tissues were stained along with 42 soft tissue sarcomas, 16 benign soft tissue proliferations, and 7 epithelial tumors. In all nonneoplastic tissue, there was intense labeling of cell processes of perivascular fibroblasts or pericytes in and about the walls of muscular blood vessels and of fibroblast cell processes around some glandular and ductal epithelia. No PDGFR-beta was found in the endothelial cells of muscular arteries and veins, but cells of uncertain identity within some capillaries were immunoreactive and the possibility that endothelial cells of some small capillaries express PDGFR-beta could not be excluded. In kidney there was strong labeling of glomerular mesangial cells and interstitial fibroblasts. Some histological types of soft tissue sarcomas were uniformly and strongly labeled with anti-PDGFR-beta, but other types were infrequently labeled or unreactive. The order of decreasing frequency and strength of labeling of the various types of benign and malignant soft tissue proliferations was as follows: benign fibromatosis and neurofibroma greater than malignant fibrous histiocytoma greater than liposarcoma greater than leiomyosarcoma greater than rhabdomyosarcoma. No tumor cell labeling was detected in epithelioid, synovial or clear cell sarcomas, leiomyomas, or carcinomas, but there was usually strong labeling of fibroblast and/or pericyte cell processes within tumor, especially around blood vessels. We conclude that PDGFR-beta is strongly expressed by vascular and stromal tissues of most tumors and normal organs and by tumor cells of several types of soft tissue tumors and proliferations, most notably those of fibroblastic origin.
Mobility and height detection of particle labels in an optical evanescent wave biosensor with single-label resolution (2010)

Abstract\nParticle labels are used in biosensors to detect the presence and concentration of analyte molecules. In this paper we demonstrate an optical technique to measure the mobility and height of bound particle labels on a biosensor surface with single-label resolution. The technique is based on the detection of the particle-induced light scattering in an optical evanescent field. We show that the thermal particle motion in the evanescent optical field leads to intensity fluctuations that can accurately be detected. The technique is demonstrated using 290 bp (99 nm) DNA as an analyte, and using polystyrene particles and magnetic particles with diameters between 500 nm and 1000 nm as labels. The particle intensity histograms show that quantitative height measurements are obtained for particles with uniform optical properties, and the intensity versus position plots reflect the analyte-antibody orientation and the analyte flexibility. The novel optical detection technique will lead to biosensors with very high sensitivity and specificity.
Insights from a Successful Case of Intrahepatic Islet Transplantation into a Type 1 Diabetic Patient (2000)

We report a case of long-term (>4 yr) successful intrahepatic islet transplantation into a type 1 diabetic patient chronically immunosuppressed for a prior kidney graft. The exogenous insulin requirement decreased progressively after transplantation, and insulin treatment was withdrawn at 6 months. Glycosylated hemoglobin levels were in the normal range at 1 and 2 yr (5.3%) and increased slightly above the upper normal limit at 3 and 4 yr (6.3% and 6.4%). Fasting C peptide levels remained stable during the entire follow-up, but the proinsulin to insulin ratios increased dramatically at yr 3. Glycemic levels after an oral glucose tolerance test showed a diabetic profile at 1 yr, a normal profile at 2 yr, and an impaired glucose tolerance profile at 3 yr. Intravenous glucose tolerance test-induced first phase insulin release, present at 1 and 2 yr, disappeared at 3 yr. Diabetes-related autoantibodies (islet cell antibodies, glutamic acid decarboxylase antibodies, and tyrosine phosphatase-like protein antibodies) were undetectable before transplantation and remained so during the entire follow-up. The patient died of myocardial infarction 50 months after transplantation while she was still in good metabolic control (glycosylated hemoglobin, <6.8%) in the absence of exogenous insulin administration. The autoptic liver showed well granulated islets, richly vascularized and without evidence of lympho-mononuclear cell infiltration. The morphometrically extrapolated intrahepaticβ -cell mass was 99.9 mg. In conclusion, this successful islet graft showed a bell-shaped clinical effect, maximal at 2 yr after transplantation, followed by a slow progressive decline. The absence of allo- and autoreactivities against the transplanted islets points to a nonimmune-mediated β-cell loss as the cause of graft functional deterioration.
Image Matching of Satellite Data Based on Quadrilateral Control Networks (2012)

Abstract Automatic image matching of satellite data is a difficult process due to the complex characteristics of such image pairs, including significant translation, rotation, scaling and illumination differences. A new method is proposed where, initially, a pre‐registration is performed to coarsely align the input and reference images. Next, a dense set of corner points are extracted using the Harris operator. The strongest conjugate corner points are determined and the accuracy is improved by using least squares matching to construct a precise braced quadrilateral control network in the two images. Once the consistency of the established network pairs has been determined, it is used as a framework to match the remaining corner points. Comprehensive evaluations of the proposed method on a variety of image pairs from different sensors prove its efficiency with sub‐pixel positional accuracy.
Integrated data and speech transmission using packet reservation multiple access (2002)

The authors propose an integrated packet reservation multiple access (IPRMA) protocol for transmitting both speech and data information. While speech users are allowed to contend for reservation slots on a frame-by-frame basis, data users may reserve multiple slots across a frame to increase throughput. The protocol includes a priority mechanism which ensures that speech users have greater access to idle slots since speech packets have a more demanding delay constraint. The proposed scheme is shown to provide equitable access to channel resources for both types of users, yielding improvements in overall system performance while significantly increasing data throughput compared to a system without data packet reservation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Neonatal feeding performance as a predictor of neurodevelopmental outcome at 18 months (2005)

This study aimed to determine whether neonatal feeding performance can predict the neurodevelopmental outcome of infants at 18 months of age. We measured the expression and sucking pressures of 65 infants (32 males and 33 females, mean gestational age 37.8 weeks [SD 0.5]; range 35.1 to 42.7 weeks and mean birthweight 2722g [SD 92]) with feeding problems and assessed their neurodevelopmental outcome at 18 months of age. Their diagnoses varied from mild asphyxia and transient tachypnea to Chiari malformation. A neurological examination was performed at 40 to 42 weeks postmenstrual age by means of an Amiel-Tison examination. Feeding performance at 1 and 2 weeks after initiation of oral feeding was divided into four classes: class 1, no suction and weak expression; class 2, arrhythmic alternation of expression/suction and weak pressures; class 3, rhythmic alternation, but weak pressures; and class 4, rhythmic alternation with normal pressures. Neurodevelopmental outcome was evaluated with the Bayley Scales of Infant Development-II and was divided into four categories: severe disability, moderate delay, minor delay, and normal. We examined the brain ultrasound on the day of feeding assessment, and compared the prognostic value of ultrasound and feeding performance. There was a significant correlation between feeding assessment and neurodevelopmental outcome at 18 months (p < 0.001). Improvements of feeding pattern at the second evaluation resulted in better neurodevelopmental outcome. The sensitivity and specificity of feeding assessment were higher than those of ultrasound assessment. Neonatal feeding performance is, therefore, of prognostic value in detecting future developmental problems.