gebhart/patrepeval huggingface dataset:
THE STRUCTURE OF A CHYMOTRYPTIC PEPTIDE FROM <i>PSEUDOMONAS</i> CYTOCHROME <i>C</i>-551 (1963)

Research Article| November 01 1963 THE STRUCTURE OF A CHYMOTRYPTIC PEPTIDE FROM PSEUDOMONAS CYTOCHROME C-551 WR GRAY; WR GRAY Search for other works by this author on: This Site PubMed Google Scholar BS HARTLEY BS HARTLEY Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1963) 89 (2): 379–380. https://doi.org/10.1042/bj0890379 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation WR GRAY, BS HARTLEY; THE STRUCTURE OF A CHYMOTRYPTIC PEPTIDE FROM PSEUDOMONAS CYTOCHROME C-551. Biochem J 1 November 1963; 89 (2): 379–380. doi: https://doi.org/10.1042/bj0890379 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search © 1963 The Biochemical Society1963 Article PDF first page preview Close Modal You do not currently have access to this content.
Characterization of an Archaeal Multidrug Transporter with a Unique Amino Acid Composition (2003)

The Smr family of multidrug transporters consists of small membrane proteins that extrude various drugs in exchange with protons rendering cells resistant to these drugs. Smr proteins identified to date have been found only in Eubacteria. In this work we present the cloning and characterization of an Smr protein from the archaeon Halobacterium salinarum, the first Smr in the archaeal kingdom. The protein, named Hsmr, was identified through sequence similarity to the Smr family, and the DNA sequence was cloned into an Escherichia coli expression system. Hsmr is heterologously expressed in a functional form despite the difference in lipid composition of the membrane and the lower salt in the cell and its environment. Cells harboring the Hsmr plasmid transport ethidium bromide in an uncoupler-sensitive process and gain resistance to ethidium bromide and acriflavine. Hsmr binds tetraphenylphosphonium (TPP(+)) with a relatively low affinity (K(D) approximately 200 nm) at low salt concentration that increases (K(D) approximately 40 nm) upon the addition of 2 m of either NaCl or KCl. The Hsmr protein contains many of the signature sequence elements of the Smr family and also a high content of negative residues in the loops, characteristic of extreme halophiles. Strikingly, Hsmr is composed of over 40% valine and alanine residues. These residues are clustered at certain regions of the protein in domains that are not important for activity, as judged from lack of conservation and from previous studies with other Smr proteins. We suggest that this high content of alanine and valine residues is a reflection of a "natural" alanine and valine scanning necessitated by the high GC content of the gene. This phenomenon reveals significant sequence elements in small multidrug transporters.
Aging of GR-S Vulcanizates in Air, Oxygen, and Nitrogen (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAging of GR-S Vulcanizates in Air, Oxygen, and NitrogenJ. Reid Shelton and Hugh WinnCite this: Ind. Eng. Chem. 1944, 36, 8, 728–730Publication Date (Print):August 1, 1944Publication History Published online1 May 2002Published inissue 1 August 1944https://doi.org/10.1021/ie50416a013RIGHTS & PERMISSIONSArticle Views18Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (400 KB) Get e-Alerts
Poly(vinyl pyrrolidone):  A Dual Functional Reductant and Stabilizer for the Facile Synthesis of Noble Metal Nanoplates in Aqueous Solutions (2006)

Poly(vinyl pyrrolidone) (PVP) has been extensively used in the solution-phase synthesis of many types of colloidal particles, where it is mainly considered as a steric stabilizer or capping agent with a major role to protect the product from agglomeration. In a recent study, we discovered that the hydroxyl end groups of PVP could also serve as a very mild reductant for kinetically controlled synthesis of Ag nanoplates with yields as high as 75%. Here we further demonstrate that hydroxyl-terminated PVP is also a well-suited reductant for the aqueous synthesis of circular, triangular, and hexagonal nanoplates made of other noble metals including Pd, Au, and Pt. The reduction kinetics of a metal salt by the hydroxyl end groups of PVP can be maneuvered in at least two different ways to facilitate the evolution of plate morphology: (i) by adjusting the molar ratio of PVP to the salt precursor and (ii) by altering the molecular weight of PVP. Unlike previously reported studies of Ag and Au thin plates, light was found to have a negligible role in the present synthesis.
Expression of cellular homologues of retroviral onc genes in human hematopoietic cells. (1982)

Total cellular poly(A)-enriched RNA from a variety of fresh human leukemic blood cells and hematopoietic cell lines was analyzed for homology with molecularly cloned DNA probes containing the onc sequence of Abelson murine leukemia virus (Ab-MuLV), Harvey murine sarcoma virus (Ha-MuSV), simian sarcoma virus (SSV), and avian myelocytomatosis virus strain MC29. Results with the fresh blood cells paralleled those obtained with the cell lines. With Ab-MuLV and Ha-MuSV, multiple RNA bands were visualized in all cell types examined without significant variation in the relative intensities of the bands. When SSV was used as the probe, expression of related onc sequences was absent in all of the hematopoietic cell types examined except for one neoplastic T-cell line (HUT 102), which produces the human T-cell leukemia (lymphoma) retrovirus HTLV. In this cell line, a single band (4.2 kilobases) was observed. With MC29 as the probe, a single band of 2.7 kilobases was visualized in all cell types examined with only a 10 to 2-fold variation in intensity of hybridization. An exception was the promyelocytic cell line, HL60, which expressed approximately 10-fold more MC29-related onc sequences. With induction of differentiation of HL60 with either dimethyl sulfoxide or retinoic acid, a marked diminution in the amount of the MC29-related, but not the Ab-MuLV-related, onc message was observed.
The effect of having unequal branch gains practical predetection diversity systems for mobile radio (1977)

A review of practical predetection diversity techniques for mobile radio is presented. Theoretical carrier-to-noise distributions for selection combining, equal-gain combining, and maximal ratio combining in two-branch predection diversity systems are derived as a function of gain unbalance between branches. Experimental results are also presented from an equal-gain system, including predetection level statistics and post detection baseband average noise measurements as a function of gain unbalance. It was found that unbalances as high as 10 dB can be tolerated with equivalent input signal-to-noise degradations less than 3 dB for equal-gain and maximal ratio systems. Selection diversity degrades much faster than equal-gain or maximal ratio, but significant diversity improvement is given for unbalances less than 6 dB.
Miniband-related 1.4–1.8 μm luminescence of Ge/Si quantum dot superlattices (2006)

Abstract The luminescence properties of highly strained, Sb-doped Ge/Si multi-layer heterostructures with incorporated Ge quantum dots (QDs) are studied. Calculations of the electronic band structure and luminescence measurements prove the existence of an electron miniband within the columns of the QDs. Miniband formation results in a conversion of the indirect to a quasi-direct excitons takes place. The optical transitions between electron states within the miniband and hole states within QDs are responsible for an intense luminescence in the 1.4–1.8 µm range, which is maintained up to room temperature. At 300 K, a light emitting diode based on such Ge/Si QD superlattices demonstrates an external quantum efficiency of 0.04% at a wavelength of 1.55 µm.
Rendering with radiance: the art and science of lighting visualization (1998)

Radiance is a collection of approximately 50 programs that do everything from object modeling to point calculation, rendering, image processing and display. This is the definitive reference on the radiance lighting simulation and rendering system.
Self-Powered System with Wireless Data Transmission (2011)

We demonstrate the first self-powered system driven by a nanogenerator (NG) that works wirelessly and independently for long-distance data transmission. The NG was made of a free cantilever beam that consisted of a five-layer structure: a flexible polymer substrate, ZnO nanowire textured films on its top and bottom surfaces, and electrodes on the surfaces. When it was strained to 0.12% at a strain rate of 3.56% S(-1), the measured output voltage reached 10 V, and the output current exceeded 0.6 μA (corresponding power density 10 mW/cm(3)). A system was built up by integrating a NG, rectification circuit, capacitor for energy storage, sensor, and RF data transmitter. Wireless signals sent out by the system were detected by a commercial radio at a distance of 5-10 m. This study proves the feasibility of using ZnO nanowire NGs for building self-powered systems, and its potential application in wireless biosensing, environmental/infrastructure monitoring, sensor networks, personal electronics, and even national security.
Selective transport of polymeric immunoglobulin A in bile. Quantitative relationships of monomeric and polymeric immunoglobulin A, immunoglobulin M, and other proteins in serum, bile, and saliva. (1982)

In 17 adults, serum, hepatic bile, and saliva samples were analyzed for their sedimentation profile of IgA and secretory component (SC), and for their concentrations of albumin, orosomucoid, transferrin, IgG, IgA, alpha 2-macroglobulin (alpha 2M), IgM, and SC. Polymeric IgA(p-IgA) averaged 13% (50-700 micrograms/ml) of total IgA in serum, 70% (43-88%) in bile, and 93% (74-98%) in saliva. Most of the p-IgA in bile sedimented with SC, which also occurred free (8-44%), and with IgM. In bile, albumin (155-1,485 micrograms/ml) was the predominant protein, followed by IgG (32-480 micrograms/ml), and total IgA (37-209 micrograms/ml). In saliva, p-IgA (72-902 micrograms/ml) predominated, followed by albumin (16-385 micrograms/ml) and IgG (9-178 micrograms/ml). Secretion-to-serum albumin-relative concentration ratios (S/S-ARCR = 1 for albumin) in bile averaged 22 for p-IgA, 1.91 for IgM, 1.28 for monomeric IgA (m-IgA), 0.70 for IgG, and 0.57 for alpha 2M, indicating for p-IgA, IgM, and to a lesser extent for m-IgA, a selective excretion into bile. In saliva, a 16-fold greater selective excretion of p-IgA (mean S/S-ARCR = 354) was found. Labeled m- and p-IgA were injected intravenously into five patients. Specific activities indicated that for p-IgA 50% was serum derived in bile, as compared with 2% in saliva, and to 85% for m-IgA in bile. In the patient with the highest excretion of 125I-p-IgA in bile, only 2.8% of the injected dose was recovered in bile within 24 h after injection. Compared with rats and rabbits, the serum-to-bile transport of p-IgA in humans is much smaller.
Ionic Liquid-based Thermoelectric Generator: Links between Liquid Data and Generator Characteristics (2015)

The unfavorable link between electrical- and thermal conductivity limits the choice of solid-state materials for thermoelectric generators (TEG). An interesting alternative for solid-state TEG materials is the choice of ionic liquids (IOLs) that exhibits less thermal conductivity, and has the potential for being designed for delivering optimal thermoelectric properties. Further, Seebeck coefficients(S) as high as 1 mV/K could be shown by previous work [1], [2]. It appears that the key factor that limits the electro-thermal conversion efficiency for IOL-based TEGs must not only be seen in the conductivity but rather in the carrier extraction at the liquid-solid interface of the electrodes. The objective of the paper is to study the dominating mechanisms for free charge generation, free carrier separation and current extraction. A link between macroscopic IOL data (viscosity, electrical conductivity)and the generator performanceis aimed to be drawn. It is shown that viscosity and electrical conductivity of the liquids are linked via intermolecular mechanical, thermal and electrostatic forces. The polarity of the Seebeck Coefficients seems to be due to a specific affinity of one ion type to the heated electrode and the necessary thermal activation energy to initiate the oxidation and reduction process is reduced by the created electric field.
A Hybrid Model to Detect Malicious Executables (2007)

We present a hybrid data mining approach to detect malicious executables. In this approach we identify important features of the malicious and benign executables. These features are used by a classifier to learn a classification model that can distinguish between malicious and benign executables. We construct a novel combination of three different kinds of features: binary n-grams, assembly n-grams, and library function calls. Binary features are extracted from the binary executables, whereas assembly features are extracted from the disassembled executables. The function call features are extracted from the program headers. We also propose an efficient and scalable feature extraction technique. We apply our model on a large corpus of real benign and malicious executables. We extract the above mentioned features from the data and train a classifier using support vector machine. This classifier achieves a very high accuracy and low false positive rate in detecting malicious executables. Our model is compared with other feature-based approaches, and found to be more efficient in terms of detection accuracy and false alarm rate.
Max-Sum diversification, monotone submodular functions and dynamic updates (2012)

Result diversification has many important applications in databases, operations research, information retrieval, and finance. In this paper, we study and extend a particular version of result diversification, known as max-sum diversification. More specifically, we consider the setting where we are given a set of elements in a metric space and a set valuation function f defined on every subset. For any given subset S, the overall objective is a linear combination of f(S) and the sum of the distances induced by S. The goal is to find a subset S satisfying some constraints that maximizes the overall objective.
Recommendations by the EACD for examination, diagnosis, and management of patients with temporomandibular disorders and orofacial pain by the general dental practitioner. (2008)

The Council of the European Academy of Craniomandibular Disorders charged the Educational Committee with the task of establishing Guidelines and Recommendations for the examination, diagnosis, and management of patients with temporomandibular disorders and orofacial pain by the general dental practitioner. It was not their purpose to present a thorough and critical review of the vast amount of literature available but to summarize the at-present generally accepted clinical approach. These recommendations are based as much as possible on scientific evidence and on sound clinical judgment in cases where only partial evidence or contradictory data were found.
<scp>mTORC</scp>1 and <scp>mTORC</scp>2 as regulators of cell metabolism in immunity (2017)

The mechanistic target of rapamycin (mTOR) pathway is an evolutionarily conserved signaling pathway that senses intra- and extracellular nutrients, growth factors, and pathogen-associated molecular patterns to regulate the function of innate and adaptive immune cell populations. In this review, we focus on the role of the mTOR complex 1 (mTORC1) and mTORC2 in the regulation of the cellular energy metabolism of these immune cells to regulate and support immune responses. In this regard, mTORC1 and mTORC2 generally promote an anabolic response by stimulating protein synthesis, glycolysis, mitochondrial functions, and lipid synthesis to influence proliferation and survival, effector and memory responses, innate training and tolerance as well as hematopoietic stem cell maintenance and differentiation. Deactivation of mTOR restores cell homeostasis after immune activation and optimizes antigen presentation and memory T-cell generation. These findings show that the mTOR pathway integrates spatiotemporal information of the environmental and cellular energy status by regulating cellular metabolic responses to guide immune cell activation. Elucidation of the metabolic control mechanisms of immune responses will help to generate a systemic understanding of the immune system.
A DNA Methyltransferase Inhibitor and<i>All-trans</i>Retinoic Acid Reduce Oral Cavity Carcinogenesis Induced by the Carcinogen 4-Nitroquinoline 1-Oxide (2009)

The transcriptional silencing of some cell cycle inhibitors and tumor suppressors, such as p16 and retinoic acid receptor beta(2), by DNA hypermethylation at CpG islands is commonly found in human oral squamous carcinoma cells. We examined the effects of the DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine (5-Aza; 0.25 mg/kg body weight), all-trans retinoic acid (RA; given at 100 microg/kg body weight and 1 mg/kg body weight), and the combination of 5-Aza and the low-dose RA on murine oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in a mouse model. All the drug treatments were done for 15 weeks after a 10-week 4-NQO treatment. Mice in all drug treatment groups showed decreases in the average numbers of neoplastic tongue lesions. The combination of 5-Aza and RA effectively attenuated tongue lesion severity. Although all drug treatments limited the increase in the percentage of proliferating cell nuclear antigen-positive cells and the decrease in the percentage of p16-positive cells caused by the 4-NQO treatment in mouse tongue epithelial regions without visible lesions and in the neoplastic tongue lesions, the combination of 5-Aza and RA was the most effective. Collectively, our results show that the combination of a DNA demethylating drug and RA has potential as a strategy to reduce oral cavity cancer in this 4-NQO model.
A methodology for auto-recognizing DBMS workloads (2002)

The type of the workload on a database management system (DBMS) is a key consideration in tuning the system. Allocations for resources such as main memory can be very different depending on whether the workload type is Online Transaction Processing (OLTP) or Decision Support System (DSS). A DBMS also typically experiences changes in the type of workload it handles during its normal processing cycle. Database administrators must, therefore, recognize the significant shifts of workload type that demand reconfiguring the system in order to maintain acceptable levels of performance. We envision autonomous, selftuning DBMSs that have the capability to manage their own performance by automatically recognizing the workload type and then reconfiguring their resources accordingly. In this paper, we present an approach to automatically identifying a DBMS workload as either OLTP or DSS. We build a classification model based on the most significant workload characteristics that differenti ate OLTP from DSS and then use the model to identify any change in the workload type. We construct and compare classifiers built from two different sets of industry-standard workloads, namely the TPC-C and TPC-H benchmarks, and the Browsing and Ordering profiles from the TPC-W benchmark. We conduct various sets of experiments that show that our workload classifiers are reliable, and have high accuracy in recognizing the type of the workload mix and in estimating the degree of its concentration.
Experimental results on the breakdown behaviour of concrete immersed in water (2003)

The efficiency of the electric impulse fragmentation of dielectric solids immersed in water is determined by the characteristics of the discharge channel propagating from the electrode tip through the solid to the grounded electrode plate. Voltage and current measurements indicate, that the pre-breakdown phase strongly depends on the arrangement of the solid material within the discharge gap. Short discharge delay times and low energy losses can only be observed, if the electrode gap is completely filled by solid material. In this case the channel resistance calculated from the measurements shows high values. If the channel has to bridge an intermediate water gap, the discharge delay times and the energy losses increase. Compared to a channel through solid material a discharge channel in water exhibits a low channel resistance, providing a poor energy transfer into the channel. Further experiments clearly indicate that gaseous inclusions in the solid material play an important role in discharge development in minerals.
The Dehydrochlorination of Allophanoyl Chlorides. A New Synthesis of Isocyanates (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Dehydrochlorination of Allophanoyl Chlorides. A New Synthesis of IsocyanatesA. A. R. Sayigh, James N. Tilley, and Henri UlrichCite this: J. Org. Chem. 1964, 29, 11, 3344–3347Publication Date (Print):November 1, 1964Publication History Published online1 May 2002Published inissue 1 November 1964https://pubs.acs.org/doi/10.1021/jo01034a052https://doi.org/10.1021/jo01034a052research-articleACS PublicationsRequest reuse permissionsArticle Views238Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts