gebhart/patrepeval huggingface dataset:
Newer Local Anesthetics and Techniques for Administration (1981)

Bupivacaine and etidocaine are long-duration amide local anesthetics and could be useful in dentistry for long procedures and post-operative pain control. Iontophoresis of lidocaine-epinephrine will also add to the dentist's armamentarium by providing a truly effective topical anesthetic for pre-injection topical, deciduous tooth extraction and biopsies. This technique could provide a breakthrough for eliminating patient fear of needle injection, a major factor in patient anxiety which hinders acceptance of dentistry.
Novel pyrazolyl pyridazine derivatives likely to possess anti-inflammatory activity. (2010)

Reaction of 4-acetyl-5,6-diphenylpyridazin-3(2H)-one (1) with diethyl oxalate in refluxing sodium ethoxide/ethanol mixture afforded ethyl 2,4-dioxo-4-(3-oxo-5,6-diphenyl-2,3-dihydropyridazin4-yl)butanoate (2) which with hydrazine hydrate (1:1 mol) in refluxing ethanol afforded ethyl5-(3-oxo-5,6-diphenyl-2,3-dihydropyridazin 4-yl)-1H-pyrazole-3-carboxylate (3) while reaction of 2 with hydrazine hydrate (1:2 moles) in refluxing ethanol gave the corresponding acid hydrazide (4). Reaction of acid chloride (6) with primary amines namely, aniline, p-toluidine and anisidine in the presence of DMF containing K2CO3 afforded the corresponding amide derivatives (7a – c). Hydrazones (9a – c) were prepared via the reaction of the acid hydrazide (4) with appropriate aldehydes namely, benzaldehyde, p-chlorobenzaldehyde and p-nitrobenzaldehyde in refluxing ethanol/acetic acid mixture. Reaction of carboxylic acid hydrazide (4) with each of ethyl acetoacetate, acetylacetone and ethyl cyanoacetate gave the corresponding pyrazolone and pyrazole derivatives 11, 12 and 13 respectively.

	 

	Key words: Benzilmonohydrazone, pyridazine, pyrazole, ethyl acetoacetate, diethyl oxalate, acetylacetone, ethyl cyanoacetate, antihypertensive, anti-inflammatory.
Chaos in a multimode solid-state laser system (1991)

When a nonlinear crystal is placed within a multimode solid-state laser cavity, deterministic fluctuations are induced in the output intensity. In this paper, the results of our studies of the intensity noise in a diode pumped, intracavity frequency doubled Nd:YAG (neodymium doped yttrium aluminum garnet) laser will be presented. First, a novel technique to eliminate these fluctuations is described. Second, the observation of antiphase states in the laser output is discussed. These states are characterized by a cyclic periodic pulsing of the individual longitudinal mode intensities. Finally, the statistical properties of chaotic intensity fluctuations are characterized. It is be demonstrated that it is possible to accurately model the laser dynamics by a system of globally coupled, nonlinear oscillators.
Synthetic, structural and theoretical studies of amidinate and guanidinate stabilised germanium(i) dimers (2006)

The neutral germanium(i) dimers, [{Ge(Piso)}(2)] and [{Ge(Giso)}(2)], Piso = [(ArN)(2)CBu(t)](-), Giso = [(ArN)(2)CNPr(i)(2)](-), Ar = C(6)H(3)Pr(i)(2)-2,6, which are stabilised by bulky amidinate and guanidinate ligands respectively, have been prepared by reduction of the corresponding germanium(ii) chlorides, [Ge(Piso)Cl] and [Ge(Giso)Cl]; theoretical studies suggest that the Ge-Ge bonds of [{Ge(Piso)}(2)] and [{Ge(Giso)}(2)] are associated with their HOMOs, whilst their LUMOs have substantial Ge-Ge pi-bonding character.
[The testing policy for HIV infection in Ukraine]. (1999)

The policy of the Ministry of Health of the Ukraine since 1987 concerning the control of the spread of HIV infection was analyzed. The main measure for the prophylaxis and epidemiological control of the infection was mass testing for HIV, carried out in accordance with the law adopted in 1991. In 1997 changes and amendments were supplemented to this Law, which legally abolished obligatory testing for HIV. The data on the effective and less effective testing policy are presented. In particular, these data revealed that the irrational testing policy resulted on the fact that only 5% of the whole population of drug addicts were covered by surveillance. Future prospects were shown to include the introduction of the system of "patrol" epidemiological surveillance, the strengthening of the analytical component of epidemiological surveillance, the approval of the new strategic plan of the prophylaxis for AIDS for 1998-2000, as well as the renewal of the normative and methodological basis.
Results of an abbreviated phase-II study with the Akt Inhibitor MK-2206 in Patients with Advanced Biliary Cancer (2015)

Biliary cancers (BC) are rare, chemoresistant and are associated with a poor prognosis. Targeting the Akt pathway is of significance in BC. We hypothesized that the allosteric inhibitor MK-2206 will be active in BC. This was a multi-institutional phase II study of MK-2206 given to patients with advanced, refractory BC. The primary end point was overall response rate. We also characterized pharmacokinetic profiles of MK-2206 in these patients and explored its potential correlation with clinical outcomes. Eight patients were enrolled prior to early termination of the trial. All patients had received prior systemic therapy. The best response observed was stable disease, exceeding 12 weeks in two patients. Toxicities were mild and tolerable. MK-2206 exhibited a pharmacokinetic profile with an apparent slow absorption followed by biphasic elimination in these patients with BC. No significant association was observed between the pharmacokinetic properties of MK-2206 and clinical outcomes. MK-2206 as a single-agent in BC is tolerable with pharmacokinetic properties similar to patients with other solid tumors. No clinical activity was observed in this limited population. Further development of Akt inhibitors may need to focus on combinations with other molecular targeted agents, conventional cytotoxic chemotherapy and prospective patient selection.
Microscopic polyangiitis: Clinical and laboratory findings in eighty-five patients (1999)

This study demonstrated that MPA is a multisystemic disease in which renal symptoms are frequent, but the disease is also associated with general symptoms, arthritis, mononeuritis multiplex, and other manifestations that are also seen in various vasculitides. The rarity of abnormal angiogram findings and the high frequency of pANCA are characteristic of MPA. In most cases, the outcome is comparable with those of other systemic vasculitides, but relapses are frequent.
NCC: A Multidisciplinary Design/Analysis Tool for Combustion Systems (1999)

A multi-disciplinary design/analysis tool for combustion systems is critical for optimizing the low-emission, high-performance combustor design process. Based on discussions between NASA Lewis Research Center and the jet engine companies, an industry-government team was formed in early 1995 to develop the National Combustion Code (NCC), which is an integrated system of computer codes for the design and analysis of combustion systems. NCC has advanced features that address the need to meet designer's requirements such as assured accuracy, fast turnaround, and acceptable cost. The NCC development team is comprised of Allison Engine Company (Allison), CFD Research Corporation (CFDRC), GE Aircraft Engines (GEAE), NASA Lewis Research Center (LeRC), and Pratt & Whitney (P&W). This development team operates under the guidance of the NCC steering committee. The unstructured mesh capability and parallel computing are fundamental features of NCC from its inception. The NCC system is composed of a set of elements which includes grid generator, main flow solver, turbulence module, turbulence and chemistry interaction module, chemistry module, spray module, radiation heat transfer module, data visualization module, and a post-processor for evaluating engine performance parameters. Each element may have contributions from several team members. Such a multi-source multi-element system needs to be integrated in a way that facilitates inter-module data communication, flexibility in module selection, and ease of integration.
Small Cell Lung Cancer Surgery: The New Old Way (2022)

Background: We present a meta-analysis to assess the importance of surgery in stage I and II small cell lung cancer (SCLC). Today, surgery is recommended by international guidelines only in stage I disease. Mean survival analysis was executed on surgically treated patients and compared with patients that did not undergo any surgery.
Compact modeling to predict and correct stochastic hotspots in EUVL (2020)

Extreme ultraviolet lithography (EUVL) systems struggle from both low source brightness and low source throughput through the tool. For these reasons, photon shot noise will play a much larger role in image process development for EUVL than in DUV processes. Furthermore, the lower photon count increases the stochastic variation of all the processes which occur after photon absorption. This causes the printed edge to move away from the mean edge with some probability. This paper will present a model form and calibration flow for including stochastic probability bands in compact models suitable for full chip simulation. This model form relies on calibrating to statistical data from a rigorous EUV stochastic lithography model calibrated to wafer experimental data. The data generation, data preparation, and model calibration flows for the compact stochastic probability bands will be presented. We will show that this model form can predict patterns which are prone to stochastic pattern failure in realistic mask designs, as well as how this model form can be used downstream for full chip correction (e.g., SMO, OPC and/or ILT).
A versatile reporter system for CRISPR-mediated chromosomal rearrangements (2015)

Although chromosomal deletions and inversions are important in cancer, conventional methods for detecting DNA rearrangements require laborious indirect assays. Here we develop fluorescent reporters to rapidly quantify CRISPR/Cas9-mediated deletions and inversions. We find that inversion depends on the non-homologous end-joining enzyme LIG4. We also engineer deletions and inversions for a 50 kb Pten genomic region in mouse liver. We discover diverse yet sequence-specific indels at the rearrangement fusion sites. Moreover, we detect Cas9 cleavage at the fourth nucleotide on the non-complementary strand, leading to staggered instead of blunt DNA breaks. These reporters allow mechanisms of chromosomal rearrangements to be investigated.
Palladium-Assisted Routes to Nucleosides (2003)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPalladium-Assisted Routes to NucleosidesLuigi A. Agrofoglio, Isabelle Gillaizeau, and Yoshio SaitoView Author Information Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, BP 6759-Rue de Chartres, 45067 Orléans, France Cite this: Chem. Rev. 2003, 103, 5, 1875–1916Publication Date (Web):April 16, 2003Publication History Received3 May 2002Published online16 April 2003Published inissue 1 May 2003https://pubs.acs.org/doi/10.1021/cr010374qhttps://doi.org/10.1021/cr010374qresearch-articleACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views5124Altmetric-Citations362LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cross coupling reaction,Ligands,Nucleic acids,Palladium,Reaction products Get e-Alerts
A Wideband, Low Profile, Shorted Top Hat Monocone Antenna (2012)

A new, innovative, wideband antenna design which is short compared to wavelength and has an omni-directional radiation pattern that is theta polarized is investigated. The antenna design is a shorted top hat monocone that is λ/14.7 tall and has a 3:1 bandwidth. The bandwidth of the antenna was optimized by a genetic algorithm. To verify the results, a prototype was built. Modeled and measured results compared well. A link budget analysis was also performed to verify that the design performed as well or better than a monopole.
Comparative study of selenite adsorption on carbon based adsorbents and activated alumina (2003)

Abstract The Sorption characteristics of carbon‐based adsorbents such as activated carbon and chitin for the removal of selenite, Se (IV), an anionic, hazardous contaminant, are compared with those of a and y alumina. Batch experiments were conducted to determine the influence of pH, concentration of adsorbate, adsorbent loading and temperature on the sorption characteristics of the adsorbents. Generally, low pH of the solution resulted in favorable selenium removal. With the exception of activated carbon, uptakes decreased with increase in temperature. In comparison, chitin was found to be far less effective for the removal of Se (IV) from aqueous solutions. The data also showed that y alumina provided higher selenium removal percentages (99%) compared to α alumina (94%), activated carbon (87%) and chitin (49%). The selenite removal was found to decrease with increasing initial Se (IV) concentration in the solution. Adsorption capacities of the adsorbents are reported in terms of their Langmuir adsorption isotherms. The adsorption capacity (on unit mass basis) of the adsorbents for selenite is in the order: chitin (specific area (sa) =9.58 m2g‐1) < activated carbon (sa = 96.37 m2g1) < a alumina (sa = 6 m2g‐1) < y alumina (sa = 150m2g‐1).
Securing vulnerable home IoT devices with an in-hub security manager (2017)

The proliferation of consumer Internet of Things (IoT) devices offers as many convenient benefits as it poses significant vulnerabilities. Patching or otherwise mitigating these vulnerabilities will be difficult for the existing home security ecosystem. This paper proposes a central security manager that is built on top of the smarthome's hub or gateway router and positioned to intercept all traffic to and from devices. Aware of the status of all devices in the home and of reported vulnerabilities, the security manager could intervene as needed to deter or alleviate many types of security risks. Modules built atop this manager could offer convenient installation of software updates, filter traffic that might otherwise exploit devices, and strengthen authentication for both legacy and future devices. We believe that this design offers the potential to increase security for smarthome IoT devices, and we encourage other researchers and regulators to explore and extend our ideas.
Metastable phases in laser-irradiated Pt-Si and Pd-Si thin films (1980)

Amorphous phases of Pt-Si and Pd-Si covering a wide range of compositions are produced by laser-induced melting and quenching of vapor-deposited thin films. It is concluded that with the present cooling rates all compositions except those close to the congruently melting phases and the pure elements lead to amorphous films. Thermal decomposition of the Si-rich amorphous films reveals the formations of at least two metastable crystalline phases in the case of Pt-Si, and a low-temperature nucleation of the equilibrium PdSi phase in the case of Pd-Si.
Radiological Preparedness (1932)

Through your gracious consideration I am privileged to open our Seventeenth Annual Session and preside over your deliberations. To thus address you as the Executive Officer of the Radiological Society of North America is a great honor. That you have made this possible for me is sincerely appreciated. Our American Medical Association is the largest and also the most influential and democratic medical organization in the world. As such, its responsibilities are enormous. Time adds opportunities and also new responsibilities, which must be anticipated and assumed. These facts have been concisely stated by a president, who, in addressing the House of Delegates, called attention to the important position held by the American Medical Association in the social and political structure of our country. Analogous to the American Medical Association, our association, our specialty in medicine, is enjoying the privilege of being one of the largest and most active radiological societies in the world, a distinction which has been attained within the period of sixteen years. There never has been, since the beginning of medical history, an advancement of like or similar rapidity in any branch, such as we have observed in the short period since Roentgen's discovery of the X-ray in 1895. Our organization has been primarily instrumental in promoting the development and revision of this science. We must now individually and collectively combine our energies with all other radiologists to carry on this most important and valuable branch, or specialty, in the field of medicine and surgery. The Seventeenth Annual Meeting of the Radiological Society of North America which we are to-day opening is evidence of a progress of which we should be proud. We have accomplished this progress as a group, supporting a single cause. During recent years the X-ray has advanced medical science—has in many fields almost revolutionized it. Men of vision, observing this rapid progress and its consequence, suggest that we may have entered only the elementary fields of possible future developments. We, as members of the Radiological Society of North America, have been participants in this development and it is our duty to prepare our organization for the obvious future progress. Individual interest and effort are no longer sufficient to attain best results: duplication of effort must be eliminated. You all know that many of us are now members of several radiological societies and subscribers to the several official journals. This means that we must attend several official meetings each year and in many other ways divide our time and efforts in the furtherance of the common cause. This is not advantageous, it seems to me. “Where there is union there is strength.”
A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library (2009)

Venomous animals immobilize prey using protein toxins that act on ion channels and other targets of biological importance. Broad use of toxins for biomedical research, diagnosis, and therapy has been limited by inadequate target discrimination, for example, among ion channel subtypes. Here, a synthetic toxin is produced by a new strategy to be specific for human Kv1.3 channels, critical regulators of immune T cells. A phage display library of 11,200 de novo proteins is designed using the alpha-KTx scaffold of 31 scorpion toxin sequences known or predicted to bind to potassium channels. Mokatoxin-1 (moka1) is isolated by affinity selection on purified target. Moka1 blocks Kv1.3 at nanomolar levels that do not inhibit Kv1.1, Kv1.2, or KCa1.1. As a result, moka1 suppresses CD3/28-induced cytokine secretion by T cells without cross-reactive gastrointestinal hyperactivity. The 3D structure of moka1 rationalizes its specificity and validates the engineering approach, revealing a unique interaction surface supported on an alpha-KTx scaffold. This scaffold-based/target-biased strategy overcomes many obstacles to production of selective toxins.
Comparative effects of thrombopoietin and colony-stimulating factors. (1982)

The possible relationships between thrombocytopoiesis-stimulating factors (TSF or thrombopoietin) and colony-stimulating factors (CSF) were studied. Various CSF-rich preparations and two lots of TSF-rich human embryonic kidney cell culture medium were tested for their ability to stimulate 35S incorporation into platelets of immunothrombocythemic mice. The TSF-rich culture medium produced linear dose-responses between the amount of medium injected and the level of 35S incorporation into platelets of assay mice. Thirteen CSF-rich preparations were used in three separate experiments; the results indicated a lack of correlation (r = 0.003) between CSF activity and the ability of these preparations to stimulate 35S incorporation into platelets of assay mice. Moreover, purified L-cell CSF was inactive in the TSF assay. When the colony stimulating activity in preparations rich in TSF were neutralized with anti-CSF serum, the material's ability to stimulate platelet production in mice was not affected. Based on these results, we conclude that TSF and CSF are separate entities.
Human T cell lines differing in phenotype and specificity are reactive with the same anti-idiotypic antibody. (1986)

3D6, a monoclonal antibody selected for reactivity with the T cell antigen receptor on the T leukemic cell line HPB-ALL, was found to react with 3 to 13% of peripheral blood T lymphocytes of 10 out of 15 normal donors. Peripheral T cells of two donors were stimulated with allogeneic cells, and the 3D6+ cells were enriched by rosetting 3D6-coated cells with goat anti-mouse-coupled human red blood cells and were expanded in interleukin 2-containing medium. In this way, 90 to 100% 3D6+ cell lines were obtained that were cytotoxic for the allogeneic stimulator cells. 3D6 antibody could block antigen-specific cytotoxicity, as well as induce nonspecific cytotoxicity toward target cells that could not be killed in the absence of the 3D6 antibody. The 3D6+ cell populations contained T4+, as well as T8+ cells, indicating that 3D6 antibody defined a T cell receptor population that might harbor various antigenic specificities. One 3D6+ cell line was separated into T4+ T8- and T4- T8+ populations. 3D6 reactive T cell receptors isolated from HPB-ALL and normal cell lines were analyzed biochemically by means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis, isoelectric focusing, and V8 protease peptide mapping. Isoelectric focusing analysis provided additional evidence for the idea that 3D6 antibody detected a number of structurally distinct T cell receptors, because the T cell receptor alpha-chain was homogeneous in charge after desialation on the clonal tumor line HPB-ALL, but remained heterogeneous in charge on the 3D6+ normal cell lines. No great differences in charge were found between T cell receptors isolated from T4+ and T8+ 3D6+ lines, but their isoelectric focusing patterns were not identical. V8 protease peptide mapping revealed structural differences between the T cell receptor alpha-chain isolated from HPB-ALL on one hand and from the normal 3D6+ lines on the other, whereas the beta-chains did not differ greatly in primary structure according to this analysis. In addition, the peptide mapping suggested differences in primary structure between T cell receptors present on the T4+ population vs those present on the T8+ populations.