gebhart/patrepeval huggingface dataset:
DNA from diverse sources manifests cryptic low‐level transcription in <i>Escherichia coli</i> (1990)

We present evidence that DNA from diverse prokaryotic and eukaryotic sources gives rise to low-level fusion expression in Escherichia coli promoter-probe vectors. This expression may be as high as approximately 10% of the E. coli lacUV5 promoter. Although expression does not correlate with the presence of obvious E. coli promoter-like sequences, it is blocked by transcriptional terminators. Furthermore, transcription across the fusion junction is detected at levels that correlate with fusion expression. We suggest that this 'low-level transcription' (LLT) results from infrequent initiation by RNA polymerase at random sites and/or weak promoters. We propose that LLT has biological significance. In some instances, it may provide an advantageous basal level of gene expression, and we suggest that this may be true for the E. coli lacY gene. In other instances, LLT may be detrimental, in which case it may be blocked by mechanisms such as RNA secondary structure or transcriptional polarity. We present evidence to show that activation of the IS10 transposase gene by LLT is blocked at the translational level.
Super-Resolution Read-Only Memory Disk with Metal Nanoparticles or Small Aperture (2002)

We attempted to increase the signal intensity of small pits the sizes of which were smaller than the optical diffraction limit in read-only memory (ROM) disks. For this purpose we employed a granular film and a thermochromic film in this study. The reason for using these films was to apply the super-resolution near-field structure (super-RENS) model, which suggests that the signal intensity of very small marks is increased by metal nanoparticles or a small aperture in the disk, to super-ROM. We investigated the effect of adjoining these films to a reflective layer on readout signals. It was found that the signal intensity of very small pits was increased by both of these films, but the mechanisms of increase were different.
On the Collapsing Behavior of Cavitation Bubble Clusters. (2002)

The appearance of cavitation bubbles near the bubble collapsing stage was investigated on the foil section with a high-speed video camera that was triggered by the signal of impulsive force sensor. The impulsive force always occurred with the collapse of cloud cavity, and in most cases the impulsive force peak was observed several frames (95µsec. in average) before the cloud cavity appeared to be minimum in its volume. To explain this phenomenon, the shock wave propagation in the bubble cluster into its center was discussed. The authors also simulated the behavior of bubbles numerically. Spherical bubble motion and mutual interference with other bubbles were considered. The results showed that the central bubble near the wall collapsed later than the surrounding bubbles and produced the highest pressure. At that moment the surrounding bubbles had been rebounding and were in growing stage. The results correspond qualitatively to the experimental results.
Bezier-curves with curvature and torsion continuity (1986)

One of the main problems in computer-aided design is how to input shape information to the computer. In the analytic description and approximation of arbitrary shaped curves the Bezier-curves are of great importance (see A Bezier-curve is a segmented curve. The segments X/(u): = E^0 6 m/ +; JSf*(w -w// W/+1 -u/) of a Bezier-curve of degree m over the parameter interval U/ ^ u ^ W/-I-1 use the Bernstein-polynomials as blending functions. The coefficients b m/ +t are called Bezier points. They form the so called Bezier polygon, which implies the Bezier-curve.
Resonantly Induced Refractive Index Changes in Yb-doped Fibers: the Origin, Properties and Application for All-Fiber Coherent Beam Combining (2010)

Frontiers in Guided Wave
Pulmonary Embolism Secondary to Testosterone-Enhancing Herbal Supplement Use (2017)

Decreased testosterone levels in men are often a normal sign of aging. Testosterone replacement therapy (TRT) is a well-established option for those with symptomatic hypogonadism related to low testosterone levels. Conversely, designer herbal supplements in the context of testosterone supplementation are poorly studied, yet remain popular among aging men who seek the well-known, often enhancing, effects of testosterone that involve muscle mass and sexual function/drive. In 2014, the Food and Drug Administration (FDA) issued a warning about the significant risk of venous clots secondary to testosterone product use. Testosterone-induced polycythemia is one of the proposed mechanisms for this increased clotting propensity. Increased thromboxane A2 receptor density on platelets and increased platelet aggregation have also been linked to testosterone treatment in men. Fenugreek extract is a common active ingredient in commercially available herbal supplements that are often marketed as testosterone enhancers. It is thought that certain fenugreek compounds inhibit aromatase and 5-alpha-reductase activity, leading to diminished testosterone breakdown. However, the efficacy and safety profile of this agent in its use for boosting testosterone levels are unclear. In this case report, we present a patient with new-onset, bilateral pulmonary embolism possibly associated with the daily use of fenugreek-containing testosterone supplements.
Simultaneous Deposition of Submicron Aerosols onto Both Surfaces of a Plate Substrate by Electrostatic Forces (2014)

We demonstrate one-step deposition of submicrometer-sized particles suspended in the gas-phase onto a plate type substrate using an electrostatic-assisted spray system. The spray nozzle was set perpendicularly to the substrates (facing the front surface). The particles were deposited on plate-type metallic surfaces, on both front and rear sides of the substrate. This “both-side” deposition can be ascribed to deflection of charged particles in the front side, and then drifting of the particles around the rear side. A numerical simulation also showed that the deposition mechanism was found to be dependent on the center and the edge of the substrate. The electrostatic effect is more effective on both the center and the edge than the diffusion effect. [DOI: 10.1380/ejssnt.2014.238]
Albendazole: a new single dose anthelmintic. Study in 1455 patients. (1984)

Albendazole has been tested in an open trial conducted in France, seven countries of West-Africa, Martinique and the People's Republic of China in a total of 1455 patients harboring single or mixed infections caused by round-worms, pinworms, hookworms and whipworms. All patients were closely observed before and after treatment for clinical side effects and hematology and clinical chemistry values were done in about 5% of the cases. Fecal samples obtained before and approximately 15, 16 and 17 days after treatment were examined using the Kato test, and when negative, a concentration technic. In case of ancylostomiasis, a coproculture was carried out for species identification. Following a single oral dose, albendazole was highly effective in enterobiasis (100%), ascariasis (89%), ancylostomiasis caused by Necator americanus (88%) and trichuriasis (70%). The drug did not procedure any significant adverse reactions or modifications of the hematological and clinical blood chemistry values and only 6% of the 1455 patients reported minor side effects.
Intermittent pneumatic compression treatment for post-thrombotic leg ulcers (1987)

In an open clinical, trial three patients suffering from persistent post‐thromhotic leg ulcers and five patients suffering from recurrent post‐thromhotic leg‐ulcers were treated by intermittent pneumatic compression therapy. For this purpose we used a novel device which produces both a sequential and graded pressure wave on the lower leg. Compared with previous conservative treatment only, intermittent compression treatment, together with conservative treatment, was found to shorten the ulcer healing time markedly. All the persistent ulcers which had not healed during the conservative treatment period healed during the intermittent compression treatment period. Skin oxygen tension, measured during the first occasion of compression treatment, was shown to increase. The healing rates seemed to correlate with decreasing leg swelling.
eWatch: a wearable sensor and notification platform (2006)

The eWatch is a wearable sensing, notification, and computing platform built into a wrist watch form factor making it highly available, instantly viewable, ideally located for sensors, and unobtrusive to users. Bluetooth communication provides a wireless link to a cellular phone or stationary computer. eWatch senses light, motion, audio, and temperature and provides visual, audio, and tactile notification. The system provides ample processing capabilities with multiple day battery life enabling realistic user studies. This paper provides the motivation for developing a wearable computing platform, a description of the power aware hardware and software architectures, and results showing how online nearest neighbor classification can identify and recognize a set of frequently visited locations
The effect of pulse walkoff on stimulated Raman scattering in fibers (1986)

We have experimentally investigated stimulated Raman scattering in single-mode fibers in the regime of large Raman Stokes pulse walkoff from the pump pulse by the effect of group-velocity dispersion. Measurements are made with 36 ps duration pulses at 532 nm produced from a frequency-doubled and harmonically mode-locked Nd:YAG laser. We find that for 20 percent conversion, the Raman output is produced about two walkoff lengths into the fiber as a pulse of approximately the same duration as the input pulse. We also find that the Raman pulse is produced with a strong frequency chirp.
High speed parallel spectral-domain OCT using spectrally encoded line-field illumination (2018)

We report parallel spectral-domain optical coherence tomography (OCT) at 500 000 A-scan/s. This is the highest-speed spectral-domain (SD) OCT system using a single line camera. Spectrally encoded line-field scanning is proposed to increase the imaging speed in SD-OCT effectively, and the tradeoff between speed, depth range, and sensitivity is demonstrated. We show that three imaging modes of 125k, 250k, and 500k A-scan/s can be simply switched according to the sample to be imaged considering the depth range and sensitivity. To demonstrate the biological imaging performance of the high-speed imaging modes of the spectrally encoded line-field OCT system, human skin and a whole leaf were imaged at the speed of 250k and 500k A-scan/s, respectively. In addition, there is no sensitivity dependence in the B-scan direction, which is implicit in line-field parallel OCT using line focusing of a Gaussian beam with a cylindrical lens.
Assessment of a Sodium Nonatitanate and Pharmacosiderite-Type Ion Exchangers for Strontium and Cesium Removal from DOE Waste Simulants (1998)

Several inorganic ion exchangers were tested for 89Sr and 137Cs removal from simulated DOE aqueous defense wastes (NCAW and 101SY-Cs5) and a Hanford groundwater solution (N-springs). The materials used in this scoping study consisted of the three-dimensional tunnel-structured pharmacosiderites [M3H(AO)4(BO4)3·4−6H2O (M = H, K; A = Ti, Ge; B = Si, Ge)]; the layered sodium nonatitanate, Na4Ti9O20·xH2O; and two commercially available exchangers, AW-500 and clinoptilolite. 89Sr and 137Cs distribution coef ficient (Kd) measurements showed that all of the synthetic exchangers removed at least 97% of the 89Sr from the N-springs groundwater simulant in a single static equilibration. This simulant also contained parts per million levels of Ca2+, Mg2+, K+, and Na+. Similarly, many of the same materials also efficiently removed 137Cs (>98%) from the same solution, except for sodium titanate, which exhibited the lowest Kd of 1210 mL/g for Cs+. These preliminary Kd values provide an indication that these exchangers may act as dual Cs+ and Sr2+ sorbers for groundwater remediation applications. The different phases were also tested as potential exchangers for 137Cs and 89Sr in different nuclear waste simulants. While the materials showed little preference for 137Cs in highly basic solutions containing large concentrations of NaNO3, a potassium titanosilicate and the sodium titanate yielded 89Sr Kd values of 20 180 mL/g (DF = 91) and 235 120 mL/g (DF = 1177), respectively.
The pitch of chromatin DNA is reflected in its nucleotide sequence. (1980)

A correlation analysis of chromatin DNA nucleotide sequences reveals the clear tendency of some of the dinucleotides to be repeated along the sequences with periods of 3 and about 10.5 bases. This latter period, which is equal within experimental error to recent estimates of the pitch of the DNA double helix [Wang, J. (1979) Proc. Natl. Acad. Sci. USA 76, 200-203; Trifonov, E. & Bettecken, T. (1979) Biochemistry 18, 454-456] is interpreted as a reflection of the deformational anisotropy of the DNA molecule that facilitates its smooth folding in chromatin.
OPTICAL AND THERMAL CHARACTERIZATION OF NATURAL (<i>Sepia officinalis</i>) MELANIN (1994)

The optical properties and the thermal diffusivity of natural cuttlefish (Sepia officinalis) melanin have been measured. The optical absorption and scattering properties of melanin particles were determined at 580 nm and 633 nm, using photometric and photothermal techniques. For the photometric studies, the absorption and the transport scattering coefficients were determined from the measurements of diffuse reflectance and transmittance. The scattering anisotropy was obtained from an additional measurement of the total attenuation coefficient and independently obtained by goniometry. For photothermal studies, pulsed photothermal radiometry was used to deduce the absorption and transport scattering coefficients via a model based on optical diffusion theory. Pulsed photothermal radiometry was also used to provide the thermal diffusivity of solid melanin pressed pellets.
Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations (2016)

It is believed that the developed formulation could be used as a potential vehicle for successful delivery of disulfiram, an old and inexpensive drug, into breast cancer cells and other solid tumors.
Solvent-tuned intramolecular charge-recombination rates in a conjugated donor-acceptor molecule (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvent-tuned intramolecular charge-recombination rates in a conjugated donor-acceptor moleculeLutfur R. Khundkar, Albert E. Stiegman, and Joseph W. PerryCite this: J. Phys. Chem. 1990, 94, 4, 1224–1226Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/j100367a007https://doi.org/10.1021/j100367a007research-articleACS PublicationsRequest reuse permissionsArticle Views173Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
64CuCl2 PET/CT imaging of mouse muscular injury induced by electroporation. (2017)

Skeletal muscle injury is common in body injuries suffered in sports and car accidents. Development of new tracers is significant for assessing muscular injury with positron emission tomography/computed tomography (PET/CT) and monitoring repair of muscle injury in response to treatment. Copper is required for wound healing and increased copper ions were detected in the soft tissue of wound in rodents and human. Based on the recent finding of increased (64)Cu uptake in the traumatic brain injury, this study aimed to explore use of (64)CuCl(2) as a radiotracer for molecular imaging of muscular injury using PET/CT. Focally increased (64)Cu uptake by the injured muscular tissue (5.4 ± 1.2% ID/g) was detected in the C57BL/6 mice with electroporation-induced skeletal muscle injury by PET/CT after intravenous injection of (64)CuCl(2) as a tracer, compared to low (64)Cu uptake associated with muscular inflammation induced by intramuscular injection of lipopolysaccharides (0.82 ± 0.26% ID/g, P < 0.01) or physiological (64)Cu uptake of the non-injured muscular tissues (0.78 ± 0.20% ID/g, P < 0.01). The findings support further investigation of (64)CuCl(2) as a new radiotracer for molecular imaging of skeletal muscle injury using PET/CT.
Total Synthesis of Bryostatin 2 (1999)

The total synthesis of the marine macrolide bryostatin 2 is described. The synthesis plan relies on aldol and directed reduction steps in order to construct the anti-1,3-diol array present in each of the principal subunits (A, B, and C). These fragments were coupled using a Julia olefination and subsequent sulfone alkylation. A series of functionalization reactions provided a bryopyran seco acid, which was macrolactonized under Yamaguchi conditions. Installation of the two enoate moieties took advantage of asymmetric phosphonate and aldol condensation strategies. Reduction of the C20 ketone and simple protecting group operations then completed the synthesis of bryostatin 2. This flexible approach should provide access to a series of new analogues of this clinically important marine natural product.
Multipipeline networking for compound vector processing (1988)

An efficient vector-processing technique is proposed; it is based on a novel concept of multipipeline networking, which is generalized from the techniques of pipeline chaining and systolization. The authors also present the design principles of pipeline nets and provide programming, compiling and run-time techniques for converting scientific programs into pipeline net implementations. Performance analysis of the pipeline net is provided with projected performance of various Livermore loops implemented with pipeline nets of various sizes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An Optoelectronic Resistive Switching Memory with Integrated Demodulating and Arithmetic Functions (2015)

A multifunctional optoelectronic resistive switching memory, composed of a simple ITO/CeO2- x/AlOy/Al structure, is demonstrated. Arising from the photo-induced detrapping, electrode-injection and retrapping of electrons in the CeO2-x/AlOy/Al interfacial region, the device shows broadband, linear, and persistent photoresponses that can be used for the integration of demodulating, arithmetic, and memory functions in a single device for future optoelectronic interconnect systems.
Synthesis of Medium-Sized Rings by the Ring-Closing Metathesis Reaction (2000)

Conformational constraints are the keys for the efficient synthesis of medium-sized rings by ring-closing olefin metathesis (RCM). While the RCM reaction has already proved itself in the synthesis of the larger macrocycles, like that found in epothilone, only recently has this reaction been increasingly used in the construction of eight- to ten-membered carbo- and heterocycles. In the picture, a cyclopentane ring ensures the conformational constraints necessary for a successful cyclization.
Perceptions of and Constraints upon Pregnancy-Related Referrals in Rural Rajasthan, India (2000)

Mortality associated with complications of pregnancy and childbirth remains disproportionately high in the developing world. This paper reports on a study into the reasons for the poor uptake of referrals to specialist medical units in a group of 276 women in a rural area in the state of Rajasthan, India. Of the 276 cases that were referred, 242 (88%) of the women failed to attend for specialist consultation. In-depth personal interviews were conducted and a series of focus group discussions was held with the women and with their spouses and spouses' mothers. A range of geographic, cultural, socio-economic and medico-administrative factors was identified as influencing decisions to attend referral units. Recommendations for improving uptake include improving facilities at referral units, providing additional training for healthcare staff (covering technical, managerial and behavioural aspects) and in counselling techniques, a better defined role for traditional birth attendants, improved understanding of the mother's needs by her family (particularly the spouse and his mother) and increasing public awareness of the importance of referral. Finally, there is the requirement that women are encouraged to realize and understand their own needs.
HeteroMates: Providing high dynamic power range on client devices using heterogeneous core groups (2012)

This paper presents HeteroMates, a solution that uses heterogeneous processors to extend the dynamic power/performance range of client devices. By using a mix of different processors, HeteroMates offers both high performance and reduced power consumption. The solution uses core groups as the abstraction that groups a small number of heterogeneous cores to form a single execution unit. Group heterogeneity is exposed as multiple heterogeneity (H) states, an interface similar to the P-state interface already used for frequency scaling. An H-state controller governs H-state transitions based on dynamic policies maximizing performance or minimizing power consumption, while a `core switcher' transparently migrates tasks to the appropriate core, i.e., the one matching the chosen H-state. Experimental evaluations use real-world client applications and a unique experimental testbed comprised of heterogeneous cores and a shared uncore component. Results show that core groups can provide significant performance improvements while also lowering energy consumption for a diverse set of applications when compared to homogeneous processor configurations. Also demonstrated is the importance of `uncore' power in total SoC power consumption and the need for uncore power scalability when seeking to extend a platform's dynamic power range.
Design and fabrication of phonon traps to reduce the density of quasi-particles in superconducting quantum circuits (2019)

Dissertação de Mestrado Integrado em Engenharia Física apresentada à Faculdade de Ciências e Tecnologia
Notes on the Turbellarian Fauna of Rochester (N. Y.) with Special Reference to the Anatomy of Macrostomum ontarioense n. sp. (1943)

Frederick Ferdinand Ferguson, Notes on the Turbellarian Fauna of Rochester (N. Y.) with Special Reference to the Anatomy of Macrostomum ontarioense n. sp., The American Midland Naturalist, Vol. 29, No. 2 (Mar., 1943), pp. 425-428