gebhart/patrepeval huggingface dataset:
Transcriptional Insulation of the Human Keratin 18 Gene in Transgenic Mice (1993)

Expression of the 10-kb human keratin 18 (K18) gene in transgenic mice results in efficient and appropriate tissue-specific expression in a variety of internal epithelial organs, including liver, lung, intestine, kidney, and the ependymal epithelium of brain, but not in spleen, heart, or skeletal muscle. Expression at the RNA level is directly proportional to the number of integrated K18 transgenes. These results indicate that the K18 gene is able to insulate itself both from the commonly observed cis-acting effects of the sites of integration and from the potential complications of duplicated copies of the gene arranged in head-to-tail fashion. To begin to identify the K18 gene sequences responsible for this property of transcriptional insulation, additional transgenic mouse lines containing deletions of either the 5' or 3' distal end of the K18 gene have been characterized. Deletion of 1.5 kb of the distal 5' flanking sequence has no effect upon either the tissue specificity or the copy number-dependent behavior of the transgene. In contrast, deletion of the 3.5-kb 3' flanking sequence of the gene results in the loss of the copy number-dependent behavior of the gene in liver and intestine. However, expression in kidney, lung, and brain remains efficient and copy number dependent in these transgenic mice. Furthermore, herpes simplex virus thymidine kinase gene expression is copy number dependent in transgenic mice when the gene is located between the distal 5'- and 3'-flanking sequences of the K18 gene. Each adult transgenic male expressed the thymidine kinase gene in testes and brain and proportionally to the number of integrated transgenes. We conclude that the characteristic of copy number-dependent expression of the K18 gene is tissue specific because the sequence requirements for transcriptional insulation in adult liver and intestine are different from those for lung and kidney. In addition, the behavior of the transgenic thymidine kinase gene in testes and brain suggests that the property of transcriptional insulation of the K18 gene may be conferred by the distal flanking sequences of the K18 gene and, additionally, may function for other genes.
A complete, local and parallel reconfiguration algorithm for cube style modular robots (2003)

We present a complete, local, and parallel reconfiguration algorithm for metamorphic robots made up of Telecubes, six degree of freedom cube shaped modules currently being developed at PARC. We show that by using 2 /spl times/ 2 /spl times/ 2 meta-modules we can achieve completeness of reconfiguration space using only local rules. Furthermore, this reconfiguration can be done in place and massively in parallel with many simultaneous module movements. Finally we present a loose quadratic upper bound on the total number of module movements required by the algorithm.
Senescence of rin, rin/rin, rin/+ and +/+ tomato fruits (2004)

Ripening inhibitor (rin) gene is a spontaneous recessive mutant which changes fruit ripening aspects (most important synthesis of carotene, especially lycopene). It also delays fruit senescence. Tomato is a vegetable crop with specific maturing climax (pik). Tomato genotypes homozygote for rin gene does not have this maturing climax, so the ethyl-ene production and red, lycopene colour does not appear. In order to research the maturing process material from the final tomato selection cycle we used: pure line S-49 (genetic constitution u/u, with uniform ripening), line hom 4 (rin/rin, homozygote with ripening inhibitor) and hybrid combination 449 Fl (u/rin, heterozygote for ripening inhibitor). Fruits with uniform ripening and hybrids ripened simultaneously, while homozygote with rin gene did not ripe at all. Ethylene stimulates the appearance of yellow colour in rin fruits and the lycopene production. After treatment with ETEPHONE (0.1%) (Ethylene) fruits with uniform ripening, senescence more quickly, while hybrids senescence slowly. Rin homozygotes did not change colors, but the fruits senescence more quickly comparing to control. Ethylene treatment speeded the maturing and senescence process in tomato fruits. Extended maturing process as a result influence of rin gene, makes the new created hybrids a late maturing ones. On the other hand, the firmness of fruits is improved as well as the "shelf life", which enables longer transportation and storing, coordinated maturing according to market demands. The aim was to research the maturing according to market demands. The aim was to research the maturing process of rin heteroyzgote, and the reaction of some genotypes to treatment with RT-REL (Ethzlene) in order to decrease extremely late maturing.
Comparison and assessment of semi‐automatic image segmentation in computed tomography scans for image‐guided kidney surgery (2011)

Use of the algorithm shortened user interaction time and provided results which were comparable to the gold standard of hand segmentation. Further, the use of the algorithm's resultant surfaces in image registration provided comparable transformations to surfaces produced by hand segmentation. These data support the applicability and utility of such an algorithm as part of an image guidance workflow.
Tissue-Type Imaging for Ultrasound-Prior Microwave Inversion (2018)

In this paper we show results of applying the composite tissue-type imaging method to reconstructions of ultrasound-guided microwave inversions. Structural prior information about the object-of-interest undergoing quantitative microwave imaging is provided to the microwave inversion algorithm via an ultrasound ray-based imaging technique that utilizes a qualitative delay-and-sum method followed by K-means segmentation. The resulting segmented image is utilized as an inhomogeneous numerical background for the microwave finite-element Contrast Source Inversion algorithm. This prior information improves the reconstruction of the complex permittivity. Subsequently, the recently derived composite tissue-type imaging technique, which produces a tissue-type map along with a corresponding probability image, is applied to the reconstructed complex permittivity images.
The Incidence and Risk Factors for Hypotension After Spinal Anesthesia Induction: An Analysis with Automated Data Collection (2002)

By using automated data collection, 5 (chronic alcohol consumption, history of hypertension, body mass index, sensory block height, and urgency of surgery) of 29 variables could be detected as having an association with hypotension after spinal anesthesia induction. The knowledge of these risk factors should be useful in increasing vigilance in those patients most at risk for hypotension, in allowing a more timely therapeutic intervention, or even in suggesting the use of alternative methods of spinal anesthesia, such as titrated continuous or small-dose spinal anesthesia.
Soluble HLA‐G and HLA‐A,‐B,‐C serum levels in patients with allergic rhinitis (2008)

The present study provides the first evidence that both sHLA-G and sHLA-A,-B,-C serum levels are significantly increased in AR patients with pollen allergy.
<scp>l</scp>‐Cysteine metabolism and its nutritional implications (2015)

L-Cysteine is a nutritionally semiessential amino acid and is present mainly in the form of L-cystine in the extracellular space. With the help of a transport system, extracellular L-cystine crosses the plasma membrane and is reduced to L-cysteine within cells by thioredoxin and reduced glutathione (GSH). Intracellular L-cysteine plays an important role in cellular homeostasis as a precursor for protein synthesis, and for production of GSH, hydrogen sulfide (H(2)S), and taurine. L-Cysteine-dependent synthesis of GSH has been investigated in many pathological conditions, while the pathway for L-cysteine metabolism to form H(2)S has received little attention with regard to prevention and treatment of disease in humans. The main objective of this review is to highlight the metabolic pathways of L-cysteine catabolism to GSH, H(2)S, and taurine, with special emphasis on therapeutic and nutritional use of L-cysteine to improve the health and well-being of animals and humans.
Self-induced transparency in InGaAs quantum-dot waveguides (2003)

We report the experimental observation and the theoretical modeling of self-induced-transparency signatures such as nonlinear transmission, pulse retardation and reshaping, for subpicosecond pulse propagation in a 2-mm-long InGaAs quantum-dot ridge waveguide in resonance with the excitonic ground-state transition at 10 K. The measurements were obtained by using a cross-correlation frequency-resolved optical gating technique which allows us to retrieve the field amplitude of the propagating pulses.
Green-emitting Silicate Phosphor Under Long Wavelength Ultraviolet Prepared by High Temperature FlameSpray Pyrolysis (2008)

Green-emitting <TEX>$Ba_{1.468}Sr_{0.5}SiO_4\;:\;Eu_{0.012},\;Y_{0.02}$</TEX> phosphor powders under long-wavelength ultraviolet light were prepared via high-temperature flame spray pyrolysis from spray solutions with and without <TEX>$NH_4Cl$</TEX> flux. The effects of the temperature of the diffusion flame and the <TEX>$NH_4Cl$</TEX> flux on the morphologies, crystal structures and photoluminescence intensities of the <TEX>$Ba_{1.468}Sr_{0.5}SiO_4\;:\;Eu_{0.012},\;Y_{0.02}$</TEX> phosphor powders were investigated. The phosphor powders obtained from the spray solution with the <TEX>$NH_4Cl$</TEX> flux had higher photoluminescence intensities compared to phosphor powders obtained from the spray solution without the flux. The photoluminescence intensity of the phosphor powders obtained from the spray solution without the flux decreased as the flow rate of the fuel gas increased. On the other hand, the photoluminescence intensity of the phosphor powders obtained from the spray solution with the flux increased as the flow rate of the fuel gas increased. The difference of in the phase purity and morphology of the powders affected the photoluminescence intensities of the phosphor powders.
Measuring Marketing Productivity: Current Knowledge and Future Directions (2004)

For too long, marketers have not been held accountable for showing how marketing expenditures add to shareholder value. As time has gone by, this lack of accountability has undermined marketers’ credibility, threatened the standing of the marketing function within the firm, and even threatened marketing's existence as a distinct capability within the firm. This article proposes a broad framework for assessing marketing productivity, cataloging what is already known, and suggesting areas for further research. The authors conclude that it is possible to show how marketing expenditures add to shareholder value. The effective dissemination of new methods of assessing marketing productivity to the business community will be a major step toward raising marketing's vitality in the firm and, more important, toward raising the performance of the firm itself. The authors also suggest many areas in which further research is essential to making methods of evaluating marketing productivity increasingly valid, reliable, and practical.
Router Placement in Wireless Sensor Networks (2006)

In this paper we propose and evaluate algorithms for placement of routers in a wireless sensor network. There are two major requirements on router placement. First, a placement must guarantee connectivity, i.e. every sensor must be able to communicate through routers with a predefined computer-connected gateway node. Second, a placement must provide robust communication in the case of router failures. This is achieved by placing redundant routers that increase the number of possible routes. Both requirements should be met by placing as few routers as possible. The proposed algorithms compute placement in an efficient and reasonably fast way
A New Family of Cyanobacterial Penicillin-binding Proteins (2008)

It is largely accepted that serine beta-lactamases evolved from some ancestral DD-peptidases involved in the biosynthesis and maintenance of the bacterial peptidoglycan. DD-peptidases are also called penicillin-binding proteins (PBPs), since they form stable acyl-enzymes with beta-lactam antibiotics, such as penicillins. On the other hand, beta-lactamases react similarly with these antibiotics, but the acyl-enzymes are unstable and rapidly hydrolyzed. Besides, all known PBPs and beta-lactamases share very low sequence similarities, thus rendering it difficult to understand how a PBP could evolve into a beta-lactamase. In this study, we identified a new family of cyanobacterial PBPs featuring the highest sequence similarity with the most widespread class A beta-lactamases. Interestingly, the Omega-loop, which, in the beta-lactamases, carries an essential glutamate involved in the deacylation process, is six amino acids shorter and does not contain any glutamate residue. From this new family of proteins, we characterized PBP-A from Thermosynechococcus elongatus and discovered hydrolytic activity with synthetic thiolesters that are usually good substrates of DD-peptidases. Penicillin degradation pathways as well as acylation and deacylation rates are characteristic of PBPs. In a first attempt to generate beta-lactamase activity, a 90-fold increase in deacylation rate was obtained by introducing a glutamate in the shorter Omega-loop.
Feed and Animal Factors Influencing Milk Fat Composition (1993)

Genetic selection for increased milk fat percentage leads to increased proportions of short-chain fatty acids in milk fat and decreased proportions of long-chain fatty acids. Milk fat composition is strongly influenced by stage of lactation; proportion of short chains (de novo synthesis) is low initially and increases until at least 8 to 10 wk into lactation. Milk fat composition is changed more by the amount and composition of dietary fat than any other dietary component. Seasonal and regional differences in milk fat composition are measurable, most likely because of local differences in feed supplies. Milk fat composition can be modified readily by changing the feeding regimen. The most significant changes in milk fat quality relate to rheological (melting) properties, which influence numerous aspects of character and quality of manufactured dairy products. Dietary fat fed to change milk fat composition may also influence contents of protein, urea, citrate, and soluble calcium in milk and influence oxidative stability and flavor. It is important for both dairy nutritionists and dairy food chemists to understand the consequences of feeding programs on milk quality.
Em busca de uma prática baseada em evidências : surgimento e crescimento das abordagens comportamentais e cognitivo-comportamentais no Brasil (2020)

Revista de Psicologia da Criança e do Adolescente. - ISSN 1647-4120. - V. 10, n. 2 (2019). - p. 12-29.
Incisionless Pubovaginal Fascial Sling Using Transvaginal Bone Anchors for the Treatment of Stress Urinary Incontinence (2004)

Early results for the incisionless sling compare favorably with the long term results for the AVWS. This minimally invasive approach has thus far not been associated with any significant complications. Elimination of the vaginal and suprapubic incisions has not compromised efficacy, and appears to reduce the incidence of urge incontinence. Long term follow-up will establish the lasting efficacy of this novel surgical technique.
Placebo controlled trial of nicotine chewing gum in general practice. (1984)

Of 2110 adult cigarette smokers originally recruited to a study of the effect of antismoking advice in general practice, 429 who reported at follow up after one year that they had tried unsuccessfully to stop smoking were offered "a special antismoking chewing gum," either nicotine gum or a placebo gum, in a double blind study. Of 200 who were willing to try the gum, 101 were randomly allocated to the nicotine gum and 99 to the placebo gum. They were followed up at six months by an unannounced home visit, at which they were interviewed and asked to provide a breath sample for analysis of carbon monoxide. Twenty five claimed that they had stopped smoking, but, of them, seven exhaled levels of carbon monoxide indicative of continued smoking. Of the 18 in whom giving up smoking was validated, 10 had received active gum and eight placebo gum, a difference which was not significant (odds in favour of nicotine gum = 1.25, 95% confidence limits 0.47-3.31). The value of nicotine chewing gum, if any, can be quite small when it is used in general practice.
Results of the Brugge Benchmark Study for Flooding Optimization and History Matching (2010)

Summary In preparation for the SPE Applied Technology Workshop (ATW) held in Brugge in June 2008, a unique benchmark project was organized to test the combined use of waterflooding-optimization and history-matching methods in a closed-loop workflow. The benchmark was organized in the form of an interactive competition during the months preceding the ATW. The goal set for the exercise was to create a set of history-matched reservoir models and then to find an optimal waterflooding strategy for an oil field containing 20 producers and 10 injectors that can each be controlled by three inflow-control valves (ICVs). A synthetic data set was made available to the participants by TNO, consisting of well-log data, the structure of the reservoir, 10 years of production data, inverted time-lapse seismic data, and other information necessary for the exercise. The parameters to be estimated during the history match were permeability, porosity, and net-to gross- (NTG) thickness ratio. The optimized production strategy was tested on a synthetic truth model developed by TNO, which was also used to generate the production data and inverted time-lapse seismic. Because of time and practical constraints, a full closed-loop exercise was not possible; however, the participants could obtain the response to their production strategy after 10 years, update their models, and resubmit a revised production strategy for the final 10 years of production. In total, nine groups participated in the exercise. The spread of the net present value (NPV) obtained by the different participants is on the order of 10%. The highest result that was obtained is only 3% below the optimized case determined for the known truth field. Although not an objective of this exercise, it was shown that the increase in NPV as a result of having three control intervals per well instead of one was considerable (approximately 20%). The results also showed that the NPV achieved with the flooding strategy that was updated after additional production data became available was consistently higher than before the data became available.
Quasi‐solid‐State Electrolytes for Low‐Grade Thermal Energy Harvesting using a Cobalt Redox Couple (2018)

Thermoelectrochemical cells, also known as thermocells, are electrochemical devices for the conversion of thermal energy directly into electricity. They are a promising method for harvesting low-grade waste heat from a variety of different natural and manmade sources. The development of solid- or quasi-solid-state electrolytes for thermocells could address the possible leakage problems of liquid electrolytes and make this technology more applicable for wearable devices. Here, we report the gelation of an organic-solvent-based electrolyte system containing a redox couple for application in thermocell technologies. The effect of gelation of the liquid electrolyte, comprising a cobalt bipyridyl redox couple dissolved in 3-methoxypropionitrile (MPN), on the performance of thermocells was investigated. Polyvinylidene difluoride (PVDF) and poly(vinylidene fluoride-co-hexafluoropropene) (PVDF-HFP) were used for gelation of the electrolyte, and the influence of the different polymers on the mechanical properties was studied. The Seebeck coefficient and diffusivity of the cobalt redox couple were measured in both liquid and gelled electrolytes, and the effect of gelation on the thermocell performance is reported. Finally, the cell performance was further improved by optimizing the concentration of the redox couple and the separation between the hot and cold electrodes, and the stability of the device over 25 h of operation is demonstrated.
Ortho-Planar Mechanisms (2000)

Abstract This paper proposes a new class of mechanisms called ortho-planar mechanisms. Ortho-planar mechanisms have links that can be simultaneously located in a single plane with motion out of that plane. Advantages of ortho-planar mechanisms include that they can be very compact, compliant ortho-planar mechanisms can be fabricated from a single sheet of material, and micro mechanical devices can be fabricated using surface micromachining methods. The potential impact of this class of mechanism is demonstrated by discussing them in the context of compliant mechanisms, metamorphic mechanisms, and micro-electromechanical systems.
Results of a Screening Method Used in a 12-Month Stool Survey for Escherichia coli 0157:H7 (1985)

Escherichia coli serotype O157:H7 has been epidemiologically linked to outbreaks of hemorrhagic colitis associated with fast-food restaurants and nursing homes. Sporadic cases now exceed those associated with outbreaks. The incidence of the organism in patients with common diarrhea syndromes and in asymptomatic persons is unknown. Routine serotyping of E. coli isolates is impractical for most clinical microbiology laboratories. We developed a screening plate by utilizing sorbitol fermentation as a biochemical marker to identify organisms for serotyping. A total of 2,552 stool samples were screened. In 106 (4.1%), sorbitol-negative E. coli were identified. Of these, two were serotype O157:H7, and both produced a Vero cell toxin. One patient had hemorrhagic colitis and the other a mild, febrile, self-limited diarrhea with no other bacterial pathogen identified. This plate provides an easy, effective method of screening for sorbitol-negative E. coli, a process facilitating the selection of organisms for serotyping and one that may help clarify this organism's role in human disease.
Truth discovery and copying detection in a dynamic world (2009)

Modern information management applications often require integrating data from a variety of data sources, some of which may copy or buy data from other sources. When these data sources model a dynamically changing world ( e.g. , people's contact information changes over time, restaurants open and go out of business), sources often provide out-of-date data. Errors can also creep into data when sources are updated often. Given out-of-date and erroneous data provided by different, possibly dependent, sources, it is challenging for data integration systems to provide the true values. Straightforward ways to resolve such inconsistencies ( e.g. , voting) may lead to noisy results, often with detrimental consequences. In this paper, we study the problem of finding true values and determining the copying relationship between sources, when the update history of the sources is known. We model the quality of sources over time by their coverage, exactness and freshness . Based on these measures, we conduct a probabilistic analysis. First, we develop a Hidden Markov Model that decides whether a source is a copier of another source and identifies the specific moments at which it copies. Second, we develop a Bayesian model that aggregates information from the sources to decide the true value for a data item, and the evolution of the true values over time. Experimental results on both real-world and synthetic data show high accuracy and scalability of our techniques.