gebhart/patrepeval huggingface dataset:
Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction (2005)

Erectile dysfunction (ED) affects up to 50% of men, between 40 and 70 years of age. In the first major trial of sildenafil in ED, at 24 weeks, improved erections were reported by 77 and 84% of men taking sildenafil 50 and 100mg, respectively. Subsequently, sildenafil has been reported to be effective in men with ED associated with diabetes and prostate cancer, and in psychogenic ED. Sildenafil is safe in men with coronary artery disease, provided it is not used with the nitrates (a contraindication). The most commonly reported adverse effects with sildenafil are headache, flushing and dyspepsia. Vardenafil is more potent and more selective than sildenafil at inhibiting phosphodiesterase-5. Vardenafil is similarly effective to sildenafil in the treatment of ED. The only advantage that vardenafil has over sildenafil is that it does not inhibit phosphodiesterase-6 to alter colour perception, a rare side effect which sometimes occurs with sildenafil. Tadalafil has a longer duration of action than sildenafil and vardenafil. Tadalafil is similarly effective as sildenafil in the treatment of ED. In comparison studies, tadalafil is preferred to sildenafil (50/100mg) by men with ED, possibly because of its longer duration of action. Of the phosphodiesterase inhibitors, tadalafil may displace sildenafil as the drug of choice among men with ED.
Apparent power and power factor in unbalanced and distorted systems. Applications in three phase load compensations (2017)

The apparent power and the derived power factor are two of the quantities of the biggest use and application inside the Electric Engineering. However, nowadays it continues staying the controversy on their definitions and more appropriate meaning in the most general situations in unbalance and distortion, and unequal resistances in the distribution lines. In the last years they have been distinguished two focuses concerning the functional definitions of apparent power: the European approach, more theoretical and better developed, and the American approach, more practical focus but with smaller rigor. Although from the point of view of their practical application, the use of a definition or another doesn't suppose important numeric differences, if present differ from the conceptual point of view. This is made notice in applications that suppose the use of modern equipments of static compensation. The apparent power of the European approach in its conception only permits parallel compensation, while the apparent power of the American approach admits the series-parallel compensation. This paper introduces the definitions of apparent power of both approaches and it establishes a discussion on its application in the three-phases loads compensation.
A practical method of image enhancement by interactive digital filtering. (1985)

A generalized form of the Wiener digital filter is described in which the user interactively varies two filter parameters to produce any desired number of filtered versions of a given image with differing blends of sharpening and smoothing qualities. Filtering is performed sufficiently rapidly, even without use of an array processor, to make application of the filter truly interactive. Use of the filter is illustrated with typical nuclear medicine images.
Hydroxyurea Accelerates the Loss of Epidermal Growth Factor? Receptor Genes Amplified As Double-minute Chromosomes in Human Glioblastoma Multiforme (1996)

These studies suggest the potential use of low-dose hydroxyurea in the treatment of GBMs.
Australian Electricity Market (2002)

A neurofuzzy methodology for online nodal load prediction is introduced that exploits the power of artificial neural networks (ANN) and fuzzy logic. ANNs are used to capture the power consumption patterns specific to a customer, while a fuzzy logic module detects departures from equilibrium (that is, previously established consumption patterns). The fuzzy-logic-based (FL) module (called PROTREN) performs signal trend identification. The proposed methodology improves the adaptability of the forecasting system to sudden changes or special events that may influence the load by temporarily distorting the general pattern and thus rendering the load signal highly unpredictable. Experiments have been performed to verify the effectiveness of the new methodology. Results show that the methodology has a better performance than those using traditional forecasting methodologies, especially when special events influencing the load occur.
Use of Minimal Free Energy and Self-Assembly To Form Shapes (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleUse of Minimal Free Energy and Self-Assembly To Form ShapesEnoch Kim and George M. WhitesidesCite this: Chem. Mater. 1995, 7, 6, 1257–1264Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/cm00054a028https://doi.org/10.1021/cm00054a028research-articleACS PublicationsRequest reuse permissionsArticle Views457Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Caloric restriction and brain function (2008)

It is now well established that caloric restriction could be used to promote successful brain aging. Data from randomized controlled trials in humans are limited. No positive effect on cognitive impairment was found probably due to methodological limitations. The long-term effects of caloric restriction in adults must be clarified before engaging in such preventive strategy. Additional animal studies must be conducted in the future to test the effects of 'multidomain' interventions (caloric restriction plus regular exercise) on age-related cognitive decline.
Ascorbate is consumed stoichiometrically in the uncoupled reactions catalyzed by prolyl 4-hydroxylase and lysyl hydroxylase. (1984)

The hydroxylation of proline and lysine residues by the collagen hydroxylases is coupled with a stoichiometric decarboxylation of 2-oxoglutarate. Ascorbate is virtually a specific requirement for these enzymes, but previous studies have demonstrated that it is not consumed during most catalytic cycles. Prolyl 4-hydroxylase and lysyl hydroxylase are known also to catalyze an uncoupled decarboxylation of 2-oxoglutarate in the absence of the peptide substrate. It is shown here that, unlike the complete hydroxylation reaction, the uncoupled decarboxylation reaction involves stoichiometric ascorbate consumption. This stoichiometric ascorbate consumption was also seen when the rate of the uncoupled prolyl 4-hydroxylase reaction was enhanced by the addition of poly(L-proline). Since collagen hydroxylases may catalyze occasional uncoupled reaction cycles even in the presence of the peptide substrates, the main function of ascorbate in these reactions in vivo is suggested to be that of reactivating the enzymes after such uncoupled cycles.
Retrotransposable elements R1 and R2 interrupt the rRNA genes of most insects. (1991)

A large number of insect species have been screened for the presence of the retrotransposable elements R1 and R2. These elements integrate independently at specific sites in the 28S rRNA genes. Genomic blots indicated that 43 of 47 insect species from nine orders contained insertions, ranging in frequency from a few percent to greater than 50% of the 28S genes. Sequence analysis of these insertions from 8 species revealed 22 elements, 21 of which corresponded to R1 or R2 elements. Surprisingly, many species appeared to contain highly divergent copies of R1 and R2 elements. For example, a parasitic wasp contained at least four families of R1 elements; the Japanese beetle contained at least five families of R2 elements. The presence of these retrotransposable elements throughout Insecta and the observation that single species can harbor divergent families within its rRNA-encoding DNA loci present interesting questions concerning the age of these elements and the possibility of cross-species transfer.
Estudo da dose excipiente: fármaco com avaliação da hiperplasia neointimal por tomografia de coerência óptica e histopatologia em artérias coronárias porcinas após o emprego do balão eluidor de sirolimus (2012)

INTRODUÇÃO: Magic TouchTM é um balão recoberto com nanopartículas carreadoras de sirolimus. Objetivamos encontrar a dose excipiente:fármaco com a maior capacidade de inibição da proliferação neointimal 28 dias após o uso desse balão pós-implante de stent não-farmacológico em artérias coronárias porcinas. MÉTODOS: Foram avaliados 14 porcos com implante coronário de stent não-farmacológico seguido por dilatação (60 segundos) com balões com relação excipiente:sirolimus 1:1, 0,5:1, 0,25:1 e 1:0 ou balão controle. Após 28 dias a hiperplasia neointimal foi estudada por tomografia de coerência óptica e histopatologia. RESULTADOS: A hiperplasia neointimal porcentual (%) avaliada pela tomografia de coerência óptica e pela histomorfometria foi de 32,2 e 35,1, 28,1 e 33,4, 17,3 e 20,9, 28,6 e 30,2, e 37,9 e 42,3 nos grupos excipiente:sirolimus 0,25:1, 0,5:1, 1:1, 1:0 e balão controle, respectivamente (P = 0,03 para excipiente:sirolimus 1:1 vs. balão controle). A espessura (mm) da neoíntima inter-hastes foi de 0,23, 0,30, 0,16, 0,24 e 0,30 nos grupos excipiente:sirolimus 0,25:1, 0,5:1, 1:1, 1:0 e balão controle, respectivamente (P < 0,01 para excipiente:sirolimus 1:1 vs. balão controle). Os escores de inflamação, injúria e deposição de fibrina foram baixos e sem diferenças significantes entre os grupos. CONCLUSÕES: Ocorreu gradual aumento da eficácia inibitória da proliferação neointimal à medida que a concentração do excipiente aumentou; a menor eficácia ocorreu com a formulação excipiente:sirolimus 0,25:1 e a mais intensa inibição foi observada com a formulação excipiente:sirolimus 1:1, a qual reduziu significantemente a proliferação neointimal em comparação com o grupo controle, com baixos índices de inflamação e injúria.
The dynamics of narrative writing in primary grade children: writing process factors predict story quality (2015)

In this study of third grade school children, we investigated the association between writing process measures recorded with key stroke logging and the final written product. Moreover, we examined the cognitive predictors of writing process and product measures. Analyses of key strokes showed that while most children spontaneously made local online revisions while writing, few revised previously written text. Children with good reading and spelling abilities made more online revisions than their peers. Two process factors, transcription fluency and online revision activity, contributed to explaining variance in narrative macrostructural quality and story length. As for cognitive predictors, spelling was the only factor that gave a unique contribution to explaining variance in writing process factors. Better spelling was associated with more revisions and faster transcription. The results show that developing writers' ability to make online revisions in creative writing tasks is related to both the quality of the final written product and to individual literacy skills. More generally, the findings indicate that investigations of the dynamics of the writing process may provide insights into the factors that contribute to creative writing during early stages of literacy.
Amperometric monitoring of sulphur dioxide in liquid and air samples of low conductivity by electrodes supported on ion-exchange membranes (1991)

An amperometric sensor is described for the determination of sulphur dioxide in both gaseous atmospheres and solutions of low conductivity. It consists of a porous Pt electrode (facing the sample) supported on one face of an ion-exchange membrane (Nafion 417) which serves as a solid polymer electrolyte. The other side of the membrane faces an internal electrolyte solution (1 mol dm–3 aqueous perchloric acid) containing the counter and reference electrodes. This sensor is inserted into a flow cell in which gaseous or electrolyte-free aqueous samples are fed by a peristaltic pump placed in a closed-loop path and SO2 is oxidized at an applied potential of 0.65 V versus Ag–AgCl. The device is found to be characterized by a high current sensitivity and a short response time, 24 A cm–2 mol–1 dm3 and 1 s respectively for gaseous samples; (0.4 A cm–2 mol–1 dm–3 and 4 s, respectively, for water solutions), and by good stability and low background noise. The dynamic range extends up to 2 × 10–4 mol dm–3(gaseous samples) and 1 × 10–3 mol dm–3(water samples) with good linearity, and detection limits of 8 × 10–9 mol dm–3(gaseous samples) and 4 × 10–7 mol dm–3(water samples) are predicted for a signal-to-noise ratio of 3. The advantages offered by this type of sensor over conventional gas-permeation membrane electrodes are discussed.
Sperm preservation in children: a prescription for consistency with both child protection and the criminal law (2011)

People under the age of 18 with cancer sometimes require treatments that render them infertile. It may therefore be necessary, during the brief interval between diagnosis and the commencement of cancer treatment, to offer them the opportunity to produce sperm, through masturbation, for cryopreservation. The article provides a framework for justifying this as a clinical activity, and avoiding it being construed as a sexual activity under the terms of the criminal law. Of equal importance, the article puts into place measures to ensure that this clinical activity is entirely consistent with the safeguarding principles of child protection.
Compressing RNNs for IoT devices by 15-38x using Kronecker Products (2019)

Recurrent Neural Networks (RNN) can be difficult to deploy on resource constrained devices due to their size.As a result, there is a need for compression techniques that can significantly compress RNNs without negatively impacting task accuracy. This paper introduces a method to compress RNNs for resource constrained environments using Kronecker product (KP). KPs can compress RNN layers by 15-38x with minimal accuracy loss. By quantizing the resulting models to 8-bits, we further push the compression factor to 50x. We show that KP can beat the task accuracy achieved by other state-of-the-art compression techniques across 5 benchmarks spanning 3 different applications, while simultaneously improving inference run-time. We show that the KP compression mechanism does introduce an accuracy loss, which can be mitigated by a proposed hybrid KP (HKP) approach. Our HKP algorithm provides fine-grained control over the compression ratio, enabling us to regain accuracy lost during compression by adding a small number of model parameters.
Feasibility study of IP Multimedia Subsystem (IMS) based Push-to-Talk over Cellular (PoC) for public safety and security communications (2006)

Feasibility of IMS based PoC over public cellular network, specifically over commercial GPRS network, has been studied for public safety and security communication. Both day-to-day routine work and emergency operation handling capability of the PoC service as well as of the network have been considered. The requirements of PSS communication have been taken as the basis for analysing the technical viability of PoC service for PSS communication. The study is based on publicly available specification documents and related literature. The technical data and factual information have been collected from technical papers, reports and news articles posted into the Internet. The thesis also included a case study comparing over-aged analogue PMR systems and possible PoC service over a nationwide commercial GSM/GPRS network for PSS communication. The key findings in favour of using PoC over commercial GPRS networks include already existed nation-wide radio coverage and roaming across the nation boarder, ease of use, special group call functionality, advanced IMS based multimedia services. The study has identified some challenges of using PoC for PSS communication, which are mainly due to the inherent latency of GPRS access network and lack of prioritisation of special groups of users in commercial networks. Though the PoC service over commercial network does not fulfil all the requirements strictly but taking into account the suggested measures, it can be a good alternative to PMR networks. Use of PoC for PSS communication requires zero initial as well as less operational expenses for the respective PSS organizations. At the same time PSS sector is a potential revenue generating market segment for the operator as well.
Highly reliable switching via phase transition using hydrogen peroxide in homogeneous and multi-layered GaZnO<sub>x</sub>-based resistive random access memory devices (2015)

Here, we propose an effective method for improving the resistive switching characteristics of solution-processed gallium-doped zinc oxide (GaZnO(x)) resistive random access memory (RRAM) devices using hydrogen peroxide. Our results imply that solution processed GaZnO(x) RRAM devices could be one of the candidates for the development of low cost RRAM.
RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab (B) for first-line treatment of HER2-negative locally recurrent or metastatic breast cancer (MBC) (2009)

1005 Background: B in combination with weekly paclitaxel or docetaxel (D) as 1st-line therapy for MBC has improved progression-free survival (PFS) compared with the respective taxane alone in two large Phase III trials. This study investigated the addition of B to standard 1st-line chemotherapy regimens for MBC. Methods: Patients were randomized in 2:1 ratio to receive B + chemotherapy or placebo (pl) + chemotherapy. Prior to randomization, investigators chose capecitabine (Cap) (2000 mg/m 2 x 14d), taxane (T) (nab-paclitaxel [260 mg/m 2 ] or D [75 or 100 mg/m 2 ], q3wk), or anthracycline (Ant)-based chemotherapy (q3wk). B or pl was administered at 15 mg/kg q3wk. Key eligibility criteria included MBC or locally-recurrent disease, no prior cytotoxic treatment, ECOG PS 0 or 1, HER2-negative disease and no CNS metastases. The primary endpoint was investigator-assessed PFS. Secondary endpoints included overall survival (OS), objective response rate (ORR), independent review of PFS, and safety. At progression, all patients were eligible for B with 2nd line chemotherapy. The Cap cohort and the pooled T or Ant (T + Ant) cohort were independently powered and analyzed in parallel using two-sided stratified log-rank test (Cap: 80% power to detect HR=0.75; T + Ant: 90% power to detect HR=0.7). Results: RIBBON-1 enrolled 1237 patients (Cap, 615; T, 307; Ant, 315) from 12/05 to 8/07 in 22 countries with a median follow-up of 15.6 months in the Cap cohort and 19.2 months in the T + Ant cohort. The results are summarized below. OS data are limited with only 33% of events. Safety was consistent with results of prior B trials. Conclusions: The addition of B to Cap, T; or Ant-based chemotherapy regimens used in 1st-line treatment of MBC resulted in statistically-significant improvement in PFS with a safety profile comparable to prior Phase III studies. [Table: see text] [Table: see text]
Characterization of a Novel Close-to-Root Papillomavirus from a Florida Manatee by Using Multiply Primed Rolling-Circle Amplification: <i>Trichechus manatus latirostris</i> Papillomavirus Type 1 (2004)

By using an isothermal multiply primed rolling-circle amplification protocol, the complete genomic DNA of a novel papillomavirus was amplified from a skin lesion biopsy of a Florida manatee (Trichechus manatus latirostris), one of the most endangered marine mammals in United States coastal waters. The nucleotide sequence, genome organization, and phylogenetic position of the Trichechus manatus latirostris papillomavirus type 1 (TmPV-1) were determined. TmPV-1 is the first virus isolated from the order of Sirenia. A phylogenetic analysis shows that TmPV-1 is only distantly related to other papillomavirus sequences, and it appears in our phylogenetic tree as a novel close-to-root papillomavirus genus.
SmCo<sub>5</sub>/Fe nanocomposite magnetic powders processed by magnetic field-assisted ball milling with and without surfactant (2007)

A magnetic field-assisted ball milling has been employed for the preparation of SmCo5 + 10 wt% Fe nanocomposite powders in the presence of oleic acid as surfactant. Milling experiments were also carried out without using surfactant and the nanocomposite powders so obtained, with and without surfactant, were investigated for their structural and magnetic properties using SEM, XRD, VSM and Mössbauer spectrometry. The field-milled SmCo5/Fe nanopowders in the presence of surfactant display a possible grain orientation and possess relatively high coercivity as compared with that of SmCo5/Fe powders obtained with field-milling or conventional milling. Mössbauer studies revealed that the formation of α-Fe(Co) (soft magnetic phase) is more pronounced for the powders milled without surfactant.
CD28 costimulation independence of target organ versus circulating memory antigen-specific CD4+ T cells (2003)

T cell receptor engagement with CD28 costimulation is generally required for naive T cell activation, whereas reactivation of memory cells is less dependent on CD28 costimulation. We studied this process in chronic beryllium disease, in which the frequency of antigen-specific CD4+ T cells in the lung is large and circulating antigen-specific cells are also detectable. In the lung, a large fraction of CD4+ T cells stopped expressing CD28 mRNA and protein, and this change in phenotype correlated with lung inflammation. In the presence of concentrations of CTLA-4Ig that inhibited the CD28-B7 interaction, beryllium-specific CD4+ T cells in lung were still able to proliferate and secrete IFN-γ in response to beryllium in culture. This functional independence of CD28 costimulation included lung CD28+ effector cells. Although lung CD4+CD28– cells retained the ability to secrete Th1-type cytokines in response to beryllium, they showed less proliferative capacity and were more susceptible to cell death compared with CD28+ T cells. In contrast to lung cells, inhibition of the CD28-B7 interaction markedly reduced responses of beryllium-specific T cells in blood. Taken together, these findings suggest transition within memory CD4+ T cells from CD28 dependence in central memory cells to functional independence and then loss of CD28 expression in effector cells.
Half-mJ All-Fiber-Based Single-Frequency Nanosecond Pulsed Fiber Laser at 2-$\mu{\rm m}$ (2011)

We report a high energy, high peak power, all-flber-based single-frequency ~15-ns pulsed laser source at ~1918.4 nm in master oscillator-power amplifier configuration. The pulsed fiber laser seed was achieved by directly modulating a continuous- wave single-frequency fiber laser using an electro-optic modulator driven by an arbitrary waveform generator to pre-shape the pulses before amplification to mitigate pulse steepening and dynamic gain saturation. One piece of large (25-μm) core, polarization-maintaining highly thulium-doped germanate glass fiber was used in the power amplifier stage to boost the energy and the peak power of the 15-ns pulses to >;0.5 mj and >;33 kW without any nonlinearities.