gebhart/patrepeval huggingface dataset:
Synthese von Oligo‐ und Polynucleotiden, XIV<sup>1)</sup> Darstellung von Desoxy‐oligonucleotiden mit 2′.3′‐[2.4‐Dimethoxy‐benzyliden]‐uridin als Phosphat‐Schutzgruppe (1968)

Abstract Anhand der Synthese von vier Desoxy‐dinucleotiden (pTpT, pApT, pCpT und pGpT) sowie vier Desoxy‐trinucleotiden (pTpTpT, pApTpT, pCpTpT und pGpTpT), die alle vier die in natürlicher DNS vorkommenden Basen enthalten, wird gezeigt, daß 2′3′‐[2.4‐Dimethoxybenzyliden]‐uridin als Phosphat‐Schutzgruppe zur Synthese beliebiger Desoxy‐oligonucleotide angewendet werden kann.
Sci‐Sat AM(1): Imaging‐05: Analytical scatter estimation for cone‐beam computed tomography (2008)

A significant challenge to the implementation of cone-beam computed tomography (CBCT) for high-resolution imaging is the high scatter to primary ratio. Scatter causes cupping and shading artifacts, increased noise and decreased contrast in reconstructed images. Methods to reduce the impact of scatter in CBCT are thus very desirable. We are investigating methods for computational scatter estimation and compensation for CBCT, with the goal of incorporating a scatter estimator within a statistical reconstruction algorithm. We have developed an analytical method for estimating single scatter, based on Klein-Nishina cross-sections. We have compared scatter estimates generated with this method with the results of high-count EGSnrc Monte Carlo simulations. The analytical estimates compare favorably with the Monte Carlo estimates. The paper will discuss our method for analytical estimation of single scatter, including the assumptions and simplifications required to render it computationally tractable, along with the results of the comparison between the analytical method and Monte Carlo simulations. The paper will extend previous results obtained with small (40 × 40 × 40 voxel) homogeneous computational phantoms to include results for larger, more clinically relevant phantoms (128 × 128 × 128 voxels, simulated 50/50 breast tissue with inserts of varying contrast). The paper will also discuss computational acceleration obtained through the use of parallel processing via the WestGrid High-Performance Computing network.
Universal Primer-Multiplex-Polymerase Chain Reaction (UP-M-PCR) and Capillary Electrophoresis–Laser-Induced Fluorescence Analysis for the Simultaneous Detection of Six Genetically Modified Maize Lines (2011)

To meet the labeling and traceability requirement of genetically modified (GM) maize and their products for trade and regulation, it is essential to develop a specific detection method for monitoring the presence of GM content. In this work, six GM maize lines, including GA21, Bt11, NK603, Bt176, Mir604, and Mon810, were simultaneously detected by universal primer-multiplex-polymerase chain reaction (UP-M-PCR), and the amplicons for the six event-specific genes as well as the endogenous Ivr gene were successfully separated by the method of capillary electrophoresis-laser-induced fluorescence (CE-LIF). The UP-M-PCR method overcame the disadvantages in conventional M-PCR, such as complex manipulation, lower sensitivity, amplification disparity resulting from different primers, etc., and in combination with CE-LIF, it obtained a high sensitivity of 0.1 ng for both single and mixed DNA samples. The established method can be widely used for the qualitative identification of the GM maize lines.
Factors for Osseous Repair and Delivery: Part II (1993)

The healing fracture, autograft, and allograft repair are associated with a panoply of unique biochemical and cellular processes. Temporal harmony between the components of these processes can ensure restoration of form and function to bony deficiencies incurred as a consequence of developmental deformity, traumatic incident, or surgical resection. Part I of this editorial describes the chronobiology of the stages of several types of naturally occurring bone repair materials and the interaction of the component cells and their biochemical products. The emphasis is on growth and inductive factors, which are keys to promoting bone regeneration.
Evaluation of a gene signature to predict single agent dacetuzumab (SGN-40) activity in patients with DLBCL (2009)

11063 Background: Dacetuzumab (SGN-40) is a humanized IgG1 monoclonal antibody that binds to CD40, mediates effector cell functions, and activates downstream apoptosis signaling pathways. Dacetuzumab has shown single-agent activity in relapsed/refractory DLBCL in phase I and phase II trials, with multiple objective responses and 1/3 of patients demonstrating tumor shrinkage, defined as a decrease in tumor volume (SPD) of at least 10%. We previously reported a 14-gene signature (ASH 2008 #1593) that was strongly associated with dacetuzumab sensitivity in DLBCL cell lines. Here, we report an initial evaluation of the gene signature as a classifier of patients likely to demonstrate tumor shrinkage after dacetuzumab therapy. Methods: The original 14 microarray probes were chosen for high correlation with in vitro dacetuzumab sensitivity (IC 25 ) in 31 NHL cell line models. Matching qRT-PCR probes were developed and confirmed to correlate with the microarray probes in paired cell line samples. In this retrospective analysis, archived paraffin blocks from a 26 patient subset of the phase I and II trials, with a diagnosis of DLBCL and available tumor measurements, were assayed by qRT-PCR. Results: Overall, 42% of patients (11/26) exhibited decreased SPD of at least 10%. Of those who were marker +, 10 out of 13 (78%) had 10% or better decreases in SPD, whereas only 1 of 13 patients who were marker - demonstrated tumor shrinkage (8%). The overall accuracy for predicting tumor shrinkage was 85% (one-sided P=0.002, by permutation test). Among the 14 genes contributing to the multivariate signature, CD22 and VNN2 were the most strongly down-regulated in specimens from patients without at least a 10% decrease in SPD (P=0.14 and P=0.10, respectively), while IGF1R and CTSC were the most strongly up-regulated (P=0.05 and P=0.08, respectively). Conclusions: A 14-gene signature appears to predict tumor shrinkage in DLBCL patients receiving dacetuzumab in single-agent clinical trials (P=0.002). A larger clinical data set will be analyzed to further evaluate the correlation of this gene signature with objective clinical response rates.. [Table: see text]
A Gate-Level Method for Transistor-Level Bridging Fault Diagnosis (2006)

The paper addresses the issue of transistor-level bridging fault diagnosis. While most of the previous bridging fault diagnosis work focuses on the gate-level bridging faults, this method provides a solution to intra-gate bridging faults diagnosis for the first time. Instead of using any transistor level simulation tools, we develop a transformation technique that allows transistor-level bridging faults to be diagnosed by the commonly used gate-level bridging faults diagnosis tools. Real diagnosis results from Philips designs are presented.
Inhibition of Cardiac Delayed Rectifier K <sup>+</sup> Current by Overexpression of the Long-QT Syndrome HERG G628S Mutation in Transgenic Mice (1998)

Mutations in the HERG gene are linked to the LQT2 form of the inherited long-QT syndrome. Transgenic mice were generated expressing high myocardial levels of a particularly severe form of LQT2-associated HERG mutation (G628S). Hearts from G628S mice appeared normal except for a modest enlargement seen only in females. Ventricular myocytes isolated from adult wild-type hearts consistently exhibited an inwardly rectifying E-4031-sensitive K+ current resembling the rapidly activating cardiac delayed rectifier K+ current (Ikr) in its time and voltage dependence; this current was not found in cells isolated from G628S mice. Action potential duration was significantly prolonged in single myocytes from G628S ventricle (cycle length=1 second, 26 degrees C) but not in recordings from intact ventricular strips studied at more physiological rates and temperature (200 to 400 bpm, 37 degrees C). ECG intervals, including QT duration, were unchanged, although minor aberrancies were noted in 20% (16/80) of the G628S mice studied, primarily involving the QRS complex and, more rarely, T-wave morphology. The aberrations were more commonly observed in females than males but could not be correlated with sex-based differences in action potential duration. These results establish the presence of IKr in the adult mouse ventricle and demonstrate the ability of the G628S mutation to exert a dominant negative effect on endogenous IKr in vivo, leading to the expected LQT2 phenotype of prolonged repolarization at the single cell level but not QT prolongation in the intact animal. The model may be useful in dissecting repolarization currents in the mouse heart and as a means of examining the mechanism(s) by which the G628S mutation exerts its dominant negative effect on native cardiac cells in vivo.
Molecular biology of <i>Leishmania</i> (1989)

Leishmania is a trypanosomatid protozoa with a digenetic life cycle. Sandflies inject promastigotes, the free living form present in their salivary glands, into mammals where the parasite colonizes macrophages, transforming into intracellular amastigotes. The cycle is completed when during a blood meal the insect ingests infected macrophages, the amastigotes are released in the gut where they transform back into promastigotes. Leishmania has to adapt to the changing life conditions, from free-living forms in the poikilothermic insect vector to obligatory intracellular parasite in the homeothermic mammalian host. It also has to adapt to the acidic pH of the macrophage's phagolysosome where amastigotes multiply. The adaptative response of Leishmania includes morphological, physiological, and biochemical changes. Promastigotes can be grown in culture medium. Studies of changes taking place during adaptation have been facilitated by the establishment of in vitro conditions that allow the transformation of amastigotes into promastigotes and vice versa. The system is well suited for studying regulation of gene expression during adaptative differentiation. Some mechanisms of mRNA processing are unique to these protozoa: trans-splicing and RNA editing. Several genes that are differentially expressed in the two stages have been studied. No obvious cis regulatory motifs have been found in the DNA.
Cigarette Smoking Practices, Perceptions and Awareness of Government Policies among Pharmacy Students in Niger Delta University in South-South Nigeria (2015)

Despite the growing problem of cigarette use, we still do not have accurate information on the prevalence and pattern in Nigerian adolescents. This study evaluated the smoking habits and associated contextual correlates among pharmacy students in a tertiary institution in Bayelsa State, Nigeria. A descriptive cross sectional research was conducted involving 210 students and utilizing pre-tested and validated questionnaires. Data was analyzed with SPSS. 16. Majority of respondents (66.4%) were aged 21-25 years; the male-female ratio was 1:0.9 and 99.3% were Christians. Smoking prevalence was 12.9% and more prevalent among males; age of smoking debut was 16-20yrs; (46.1%); majority (83.3%) smoked 1-5 sticks of cigarette per day; 16.7% and 33.3% respectively of males and females quitted smoking at the time of the study. Reasons given for quitting included knowledge of health hazard (100%), to set a new example (83.3%) and as a result of advice from relations and friends (50%); the students exhibited a very positive perception on smoking and its cessation. There were no correlations of smoking habits with age and gender but withthe level of studies. Respondents demonstrated very low levels of awareness of World No Tobacco Day and the Nigeria Tobacco Control Decree. It is strongly advised that more effective campaign strategies be adopted to reach as many young people as possible. The pharmacy curriculum should contain adequate courses on smoking effects and cessation; programmes of student bodies should incorporate tobacco cessation activities. The existing tobacco smoking restrictions and policies should be strengthened and enforced.
Elucidation of a protease-sensitive site involved in the binding of calcium to C-reactive protein (1989)

C-reactive protein (CRP) is a Ca2+-binding protein composed of five identical 23-kDa subunits arranged as a cyclic pentamer, present in greatly elevated concentration in the blood during the acute phase of processes involving tissue injury and necrosis. In the present work, it was found that treatment of human CRP with Pronase or Nagarse protease produces two major fragments which remain associated in physiological buffers but are separable under denaturing conditions. To localize the cleavage site(s), the fragments were characterized according to molecular mass, amino acid composition, partial amino acid sequence, and reactivity with monoclonal antibodies specific for the fragments and for defined CRP epitopes including residues 147-152 and 199-206. Nagarse protease cleaves the CRP subunit between residues 145 and 146, producing two fragments, 16 and 6.5 kDa (calculated molecular mass). Pronase cleaves the CRP subunit between residues 146 and 147, producing a 16-kDa fragment (A1) and a 6.5-kDa fragment (B); an additional fragment (A2) approximately 1 kDa smaller than fragment A1 is also apparently produced due to a secondary cleavage site in fragment A1. Cleavage appears to be completely inhibited in the presence of 1 mM CaCl2. Ca2+ does not protect cleaved CRP from heat-induced aggregation (i.e., precipitation) as it does the intact protein. Protease-cleaved CRP loses the ability to bind to the Ca2+-dependent ligand phosphorylcholine but remains the ability to bind to the Ca2+-independent ligand arginine-rich histone. Equilibrium dialysis indicates that intact CRP binds 2 mol of Ca2+/mol of subunit with a Kd of 6 X 10(-5) M.(ABSTRACT TRUNCATED AT 250 WORDS)
Alternating fluorene copolymers containing isothianaphthene derivatives: A study of their aggregation properties and small band gap (2008)

Abstract Several fluorene copolymers containing isothianaphthene units ( P1 , P2 , and P3 ) or similar derivatives ( P4 and P5 ) have been synthesized by Pd‐catalyzed Suzuki polymerization. The monomers containing isothianaphthene were prepared by a ring‐closure reaction with Lawesson's reagent. Strong photoluminescence (PL) quenching in the film state was observed for P1 and P2 , which was mainly due to the enhanced quinoid character formed by introducing the isothianaphthene unit. Their energy levels of the compounds were determined using cyclic voltammetry. Among the polymers tested, the polymer containing both an isothianaphthene and a selenophene unit, P2 , showed the smallest band gap of 1.85 eV. The influence of structural variation on the band gap of the polymer chains was further investigated by optimizing the geometries of several model monomers. Our results based on the optical and electrochemical properties combined with theoretical calculations showed that polymers containing isothianaphthene have small band gaps, rigid conformations, and strong tendencies to aggregation. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 3573–3590, 2008
Characterizations of Spherical Luneburg Lens Antennas with Air-gaps and Dielectric Losses (2001)

In this paper, spherical Luneburg lens antennas have been systematically analyzed using the Eigenfunction Expansion Method (EEM), The developed technique has capability of performing a complete 3-D analysis to characterize the multi-layered dielectric spherical lens with arbitrary permittivity and permeability. This paper describes the analysis technique, and presents the results of the parametric study of Luneburg lens antennas by varying design parameters suoh as the diameter of the lens antenna (up to 80 wavelength), number of spherical shells (up to 30 shells), air-gaps between spherical shells, and dielectric loss of the material. Many representative engineering design curves including the far-field patterns, wide-angle sidelobe characterizations, antenna efficiency have been presented.
The Effect of Monomolecular Films on the Evaporation of Ether Solutions. (1927)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Effect of Monomolecular Films on the Evaporation of Ether Solutions.Irving LangmuirIrving LangmuirMore by Irving Langmuir and D. B. LangmuirD. B. LangmuirMore by D. B. LangmuirCite this: J. Phys. Chem. 1927, 31, 11, 1719–1731Publication Date (Print):November 1, 1927Publication History Published online1 May 2002Published inissue 1 November 1927https://doi.org/10.1021/j150281a011RIGHTS & PERMISSIONSArticle Views267Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (724 KB) Get e-Alerts
Breast response to menopausal hormone therapy—aspects on proliferation, apoptosis and mammographic density (2007)

Breast cancer is the major malignancy among women in the Western world. The breast is clearly a target organ for sex steroid hormones and hormonal treatments have been associated with an increased risk of breast cancer. The balance between proliferation and apoptosis is important for breast cell homeostasis. Mammographic breast density has been identified as a strong and independent risk factor for breast cancer. It seems clear that there is a difference between various hormonal treatments with regard to their effects on breast density and cell proliferation. Also, not all women respond similarly to the same treatment. Combined estrogen and progestogen therapy generally will enhance density and proliferation more than treatment with estrogen alone. Certain constitutional and hormonal factors appear to be predictive of breast reactivity. Older women with a low body mass index respond more strongly to treatment. Estrogen levels have a positive and androgens a negative association to increase in density and proliferation. A combination of increased proliferation and decreased apoptosis could be one mechanism to explain the excess risk of breast cancer during combined estrogen/progestogen treatment. Tibolone seems to have less impact on breast response than conventional hormone therapy. Efforts should be made to identify those women with an adverse response to treatment as well as therapeutic principles with the least possible influence on the breast.
A simple and efficient search algorithm for block-matching motion estimation (1997)

The three-step search (TSS) algorithm for block-matching motion estimation, due to its simplicity, significant computational reduction, and good performance, has been widely used in real-time video applications. A new search algorithm is proposed for further reduction of computational complexity for motion estimation. It is shown that the proposed algorithm is simple and efficient and requires about one half of the computation for the TSS while keeping the same regularity and good performance.
Cyclodextrin Dimers as Receptor Molecules for Steroid Sensors (2000)

The dansyl-modified dimer 9 complexes strongly with the steroidal bile salts. Relative to native beta-cyclodextrin, the binding of cholate (1a) and deoxycholate (1b) salts is especially enhanced. These steroids bind exclusively in a 1:1 fashion. For other bile salts (1c-1e) both 1:1 and 1:2 complexes were observed with stabilities similar to those of native beta-cyclodextrin. This indicates that only one cavity is used, with a small contribution from the second. The difference is attributed to the absence of a 12-hydroxy group in the second group of steroids. Comparison with a dimer that lacks the dansyl moiety (6) shows that this group especially hinders the cooperative binding of la and 1b. The smaller interference in the binding of the other steroids indicates that self-inclusion of the dansyl moiety hardly occurs. This weak self-inclusion is supported by fluorescence studies. The dansyl fluorescence of dimer 9 is less blue-shifted than that of other known dansyl-appended cyclodextrin derivatives; this is indicative of a more polar micro-environment. Addition of guests causes a change in fluorescence intensity.
Detecting Filter List Evasion with Event-Loop-Turn Granularity JavaScript Signatures (2021)

Content blocking is an important part of a per-formant, user-serving, privacy respecting web. Current content blockers work by building trust labels over URLs. While useful, this approach has many well understood shortcomings. Attackers may avoid detection by changing URLs or domains, bundling unwanted code with benign code, or inlining code in pages.The common flaw in existing approaches is that they evaluate code based on its delivery mechanism, not its behavior. In this work we address this problem by building a system for generating signatures of the privacy-and-security relevant behavior of executed JavaScript. Our system uses as the unit of analysis each script’s behavior during each turn on the JavaScript event loop. Focusing on event loop turns allows us to build highly identifying signatures for JavaScript code that are robust against code obfuscation, code bundling, URL modification, and other common evasions, as well as handle unique aspects of web applications.This work makes the following contributions to the problem of measuring and improving content blocking on the web: First, we design and implement a novel system to build per-event-loop-turn signatures of JavaScript behavior through deep instrumentation of the Blink and V8 runtimes. Second, we apply these signatures to measure how much privacy-and-security harming code is missed by current content blockers, by using EasyList and EasyPrivacy as ground truth and finding scripts that have the same privacy and security harming patterns. We build 1,995,444 signatures of privacy-and-security relevant behaviors from 11,212 unique scripts blocked by filter lists, and find 3,589 unique scripts hosting known harmful code, but missed by filter lists, affecting 12.48% of websites measured. Third, we provide a taxonomy of ways scripts avoid detection and quantify the occurrence of each. Finally, we present defenses against these evasions, in the form of filter list additions where possible, and through a proposed, signature based system in other cases.As part of this work, we share the implementation of our signature-generation system, the data gathered by applying that system to the Alexa 100K, and 586 AdBlock Plus compatible filter list rules to block instances of currently blocked code being moved to new URLs.