gebhart/patrepeval huggingface dataset:
Cancer of the Uterine Cervix (2004)

HEALTH ISSUE: Cervical cancer is one of the most common malignant diseases of women; it is diagnosed in almost half a million women every year and half as many die from it annually. In Canada and other industrialized countries, its incidence has decreased due to cytology screening. However, invasive cases still occur, particularly among immigrant groups and native Canadian women. Although incidence of squamous cell carcinomas has decreased, the proportion of adenocarcinomas has increased because Pap cytology is ineffective to detect these lesions. KEY FINDINGS: In Canada, cervical cancer will cause an estimated 11,000 person-years of life lost. In most Canadian provinces, early detection is dependent on opportunistic screening. Primary prevention can be achieved through health education (sexual behavior modification) and vaccination to prevent infection from Human Papillomavirus (HPV). The initial results from vaccination trials are encouraging but wide scale use is more than a decade away. DATA GAPS AND RECOMMENDATIONS: Most cases of cervical cancer occur because the Pap smear was either false negative, was not done or not done often enough. Appropriate recommendations and guidelines exist on implementation of cytology-based programs. However, most Canadian women do not have access to organized screening. Further research is needed to 1) evaluate automated cytology systems; 2) define appropriate management of precursor lesions and 3) deliver definitive evidence of HPV testing efficacy in long-term follow-up studies with invasive cancer as an outcome and 4) provide Canadian data to justify augmenting or modifying current programs to use HPV testing in secondary triage of equivocal Pap smears.
[Health inequalities: metropolitan region and southeast and west metropolitan health services]. (1995)

Based on an inquiry that yielded national socioeconomic information, health inequalities among different quintiles of per capita income were explored in southeast and west health services of the metropolitan region. Inequalities were assessed establishing the type of health plan (state or private), occurrence of disease, access to medical attention and medications and use of health services. Fifty-eight percent of individuals living in the southeast health service and 74% of those living in the west health service had state funded health plans. This proportion was higher among subjects with lower earnings. One third of the population studied had a disease in the last three months. Ninety percent of these had medical attention. Most subjects that did not receive professional care, medicated them and felt that they did not require it. Subjects with lower earnings had greater difficulties to obtain medical attention or medications. Primary care comprises 62% of health actions and state funded sector is used by 88% of subjects of subjects of the first quintile of per capita income.
Benzoyl cellulose beads in the pure polymeric form as a new powerful sorbent for the chromatographic resolution of racemates (1991)

Abstract Cellulose‐based stationary phases are known to be very efficient and versatile chiral sorbents for the chromatographic resolution of racemates. Except for microcrystalline cellulose triacetate (CTA I), basically all other cellulose‐based phases have been prepared by coating of ca. 20% weight polymer on a wide pore silica gel used as a carrier. In this work we describe the preparation of benzoylcellulose (TBC) beads in the pure polymeric form (without inorganic carrier) from an emulsion of the organic polymer. The new material has been fully characterized and used as a chiral stationary phase for the resolution of various classes of racemic compounds such as benzylic alcohols or acetate derivatives of aliphatic alcohols and diols. The structural variety of the separated solutes as well as the irrational influence of the aromatic substituent in different classes of aryl compounds suggest that multiple interaction sites are involved in the complexation, making a prediction of the separation difficult. The benzoyl cellulose beads exhibit a very high loading capacity, which is particularly useful for preparative purposes as demonstrated for selected examples.
Transglycosylation of L-ascorbic acid (2007)

Cyclodextrin glucanotransferases (CGTase, EC 2.4.1.19) produced by mesophilic, thermophilic, and halophilic bacilli, as well as maltase (EC 3.2.1.20) produced by various strains of Saccharomyces cerevisiae have been applied for transglycosylation of L-ascorbic acid using starch, maltodextrin, gamma-cyclodextrin, and maltose as donors of glucosyl residue. The CGTases produced by thermophilic strains are the most efficient. The degree of transglucosylation is more than 60%.
Back to basics: the untreated rabbit reticulocyte lysate as a competitive system to recapitulate cap/poly(A) synergy and the selective advantage of IRES-driven translation (2007)

Translation of most eukaryotic mRNAs involves the synergistic action between the 5' cap structure and the 3' poly(A) tail at the initiation step. The poly(A) tail has also been shown to stimulate translation of picornavirus internal ribosome entry sites (IRES)-directed translation. These effects have been attributed principally to interactions between eIF4G and poly(A)-binding protein (PABP) but also to the participation of PABP in other steps during translation initiation. As the rabbit reticulocyte lysate (RRL) does not recapitulate this cap/poly(A) synergy, several systems based on cellular cell-free extracts have been developed to study the effects of poly(A) tail in vitro but they generally exhibit low translational efficiency. Here, we describe that the non-nuclease-treated RRL (untreated RRL) is able to recapitulate the effects of poly(A) tail on translation in vitro. In this system, translation of a capped/polyadenylated RNA was specifically inhibited by either Paip2 or poly(rA), whereas translation directed by HCV IRES remained unaffected. Moreover, cleavage of eIF4G by FMDV L protease strongly stimulated translation directed by the EMCV IRES, thus recapitulating the competitive advantage that the proteolytic processing of eIF4G confers to IRES-driven RNAs.
The effects of source polarization in CSAMT data over two massive sulfide deposits in Australia (1993)

Abstract Since the advent of the controlled-source audio-magnetotelluric method it has been recognized that the location and orientation of the bipole source is important in determining the response of the earth at the receiver. In this study, two-dimensional (2-D) far-field modeling has been used to illustrate the frequency-domain electromagnetic response of a simple conductive dike for two orthogonal polarizations of the source field. The current gathered from the surrounding media by the dike, when the electric field is parallel to the strike direction (E-polarization), produces a strong anomaly not seen in the perpendicular H-polarization. This model response has been identified in real data sets over the Rosebery and Flying Doctor orebodies of eastern Australia. In the case of Rosebery the E-polarization data yielded little structural information because the penetration of the signal was reduced by strong current channeling in the orebody and adjacent black shales. At the Flying Doctor prospect the model predictions held but changes in the extent of the near-field zone, for the two bipole locations, dominate the data. The changes in the source field observed over the Flying Doctor prospect are interpreted as evidence for anisotropy in the regional resistivity structure. The controlled-source is a fundamental component of the CSAMT system, and the choice of the bipole location and orientation must be made considering the geology of the target region and the surrounding regional resistivity structure.
Suppression of a double missense mutation by a mutant Phe tRNA<sup>Phe</sup>in<i>Escherichia coli</i> (1991)

We report here the isolation of a mutant tRNAPhe that suppresses a double missense auxotrophic mutation in trpA of Escherichia coli, trpA218. The doubly mutant protein product differs from wild-type TrpA by the replacements of Phe22 by Leu and Gly211 by Ser. A partial revertant TrpA phenotype can be obtained from trpA218 by changing either Leu22 back to Phe or Ser211 back to Gly. Translational suppressors were previously obtained that act at codon 211, replacing the Ser211 in the TrpA218 protein, presumably with Gly. In the present study, we selected for trpA218 suppressors caused by mutation of a cloned tRNAPhe gene, pheV. DNA sequence analysis of the suppressor isolated reveals a singular structural alteration, changing the anticodon from 5'-GAA-3' to 5'-GAG-3'. Sequencing of trpA218 confirmed the likely identity of Leu22 as CUC. The new missense suppressor, designated pheV(SuCUC), is lethal to the cell when highly expressed, as from a high copy number plasmid. This may be due to efficient replacement of Leu by Phe at CUC (and, probably, CUU) codons throughout the genome. We anticipate that pheV(SuCUC) will prove, like other missense suppressors, to be extremely useful in studies on the specificity and accuracy of decoding.
A Study on Health Belief and Health Behaviors of the Elderly (2003)

This paper focused on providing the groundwork for the development of proper nursing interventions to enhance the quality of life for the elderly by identifying the factors that may affect their health beliefs and behaviors. A survey was conducted on a group of people aged between 60 and 86 years residing in S and K cities from January to March of 2003, who agreed to participate in the research. Data was collected using instruments measuring health beliefs and health behaviors, and was analyzed by using SPSS. The results of this study are as follow. 1) Those in the group were aged between60 and 86 years, and the age was 66.94 years old. Most of them were living together with their spouses. From the survey, 83.5% replied above average on the question regarding their current health condition, whereas, 46.0% mentioned that they had some sort of diseases. 2) Overall score of the health belief was 516.05, with a mean . This indicates that the studied group held a high level of health belief, which affects their attitude and intention to lead a healthy life by placing the present life under control in harmony with nature. 3) Overall score of the health behaviors was 392.24 with a mean . For health purposes, the behaviors that the elderly people were taking were mostly static ones requiring a low level of activity. The analysis showed that they generally were involved in self-trained, individualized health care. Thus, the elderly place a higher priority on regular dietary behaviors than on physical activity. 4) The correlation between health belief, a cognitive aspect on health, and health behaviors, a behavioral aspect showed a very high linear relationship (r=.520, p
Cortisol in diabetic retinopathy. (1983)

Plasma cortisol levels and its metabolite-17-hydroxycorticosteroids from the urine of 53 patients were evaluated. These 53 patients had early and late stages of diabetic retinopathy. Values were compared with 30 cases of a control group. Plasma cortisol was found to be raised significantly in early as well as in advanced stages of retinopathy, while 17-hydroxycorticosteroid was significantly raised in earlier stages of diabetic retinopathy only. The findings suggest that increased plasma cortisol levels may take some part in the production of diabetic retinopathy.
Nucleotide sequence and gene organization of the 3'-terminal region of chrysanthemum virus B genomic RNA (1991)

DNA clones complementary to the 3'-terminal 3426 nucleotides of the genomic RNA of the carlavirus chrysanthemum virus B (CVB) have been sequenced. The sequence contains six open reading frames (ORFs) which encode putative proteins (in the 5'----3' direction) of Mr 25,749 (ORF2), Mr 11,435 (ORF3), Mr 6984 (ORF4), the triple gene block proteins, a protein Mr 34,638 (ORF5); the coat protein, and a protein of Mr 12,609 (ORF6). The latter protein is basic and contains a putative zinc finger motif. The 5'-proximal ORF1 encodes a product with substantial homology to the C-terminal portions of the putative RNA replicases of two other carlaviruses, potato viruses M and S. The analysis of the minus-sense sequence shows one ORF which encodes a polypeptide of Mr 16,817. The sequenced portion of the CVB genomic RNA contains three short internal non-coding regions, two of which are typical for carlaviruses (those between ORFs 1 and 2, and between ORFs 4 and 5), and one (between ORFs 5 and 6) is unusual. There is significant similarity in the amino acid sequences of the CVB RNA-encoded proteins and the corresponding proteins of other carlaviruses.
Synthesis, Antitumor Evaluation, and Apoptosis-Inducing Activity of Hydroxylated (<i>E</i>)-Stilbenes (2005)

The parallel solution-phase synthesis of a series of 30 monohydroxylated (E)-stilbene analogues is described. In vitro screening revealed low micromolar activity (GI(50)) against the MDA MB 468 breast cancer cell line. Activity in MDA MB 468 cells correlated with the ability to induce apoptosis following drug treatment by the most potent agents in the series, e.g., 5dy and 5jy, an observation further reinforced by AnnexinV-FITC analysis and fluorescence microscopy.
Using String Matching for Deep Packet Inspection (2008)

String matching has sparked renewed research interest due to its usefulness for deep packet inspection in applications such as intrusion detection, virus scanning, and Internet content filtering. Matching expressive pattern specifications with a scalable and efficient design, accelerating the entire packet flow, and string matching with high-level semantics are promising topics for further study.
Influence of Lung Stretch Receptors on the Cough Reflex in Rabbits (1984)

The cough reflex in anaesthetized rabbits was elicited by irritation of the larynx with ammonia, inhalation of ammonia into the lungs, and mechanical stimulation of the tracheobronchial tree with a catheter. After block of lung stretch receptors with sulphur dioxide and virtual abolition of the Breuer-Hering inflation reflex, the cough response to all three stimuli was far less frequent and, when it occurred, was weaker especially with respect to the expiratory efforts. It is concluded that the Breuer-Hering reflex enhances the cough reflex, although modification of the sensitivity of tracheobronchial cough and irritant receptors by sulphur dioxide may also influence the cough.
Ultra-wideband technology and random signal radar: an ideal combination (2003)

Ultra-wideband radar and random signal radar are two types of newly-developed radar systems. This paper introduces the special advantages of the combination of ultra-wideband technology and random signal radar to the international radar community. It shows that these two radar systems have a very close relationship in nature and can gain significant benefits from each other. It can be anticipated that the random signal modulated waveform will open many potential possibilities for the applications of ultra-wideband radar systems to civilian operating environments.
Self-Healing Glass Fibres with Carbon Nanotube-Epoxy Nanocomposite Coating (2007)

This paper reports a study based on a novel concept of ‘self-healing’ coatings applied onto the brittle fibre surface to reduce the stress concentrations and thus to improve the reinforcing efficiency in a composite. The individual E-glass fibres as well as rovings were coated with a carbon nanotube (CNT) reinforced epoxy composite. The tensile strengths were measured for the individual and bundle fibres, which were treated statistically to determine the Weibull parameters and thus to evaluate the notch sensitivity of the fibres with and without coating. The results indicate that the tensile strength of the individual fibre increased by 10% after coating with neat epoxy. Coating with epoxy nanocomposite containing 0.3wt% MWNT further improved the tensile strength. However, increasing the nanotube content was not necessarily beneficial due to the formation of nanotube agglomerates within the matrix. The tensile tests on fibre roving also showed a clear trend of beneficial effect of nanocomposite impregnation on tensile strength. The rovings impregnated with nanocomposite exhibited a more uniform strength distribution and higher strengths than those impregnated with neat epoxy. Changes in prevailing failure mechanisms influenced by the epoxy and nanocomposite coatings are identified.
Effects of Reaction Conditions on the Plasma Polymerization of Ethylene (1974)

Abstract Ehylene can be polymerized at low pressures in a radio-frequency glow discharge. The form of the resulting polymer may be a powder at low pressure (1 to 2 Torr) and low monomer feed rate (10 to 40 cc/min), a colorless film at low pressure and high feed rate (70 to 90 cc/min), or an oil at high pressure (4 to 5 Torr) and high feed rate. The powder and film forms of plasma-polymerized ethylene are insoluble in common organic solvents, indicating a highly cross-linked structure. The oily products, however, are soluble in acetone and xylene. Chemical evidence indicates that the oil is most likely composed of highly branched oligomers of ethylene. Mass spectrometric analysis of the gaseous effluents show that under film-forming conditions the only hydrocarbon species observable are those derived from ethylene. The powder- and oil-forming conditions, on the other hand, yielded oligomeric species. On the basis of this evidence, a mechanism for the plasma-polymerization of ethylene is proposed.
Ultrasonic velocity measurement for the determination of density in polyethylene (1984)

Abstract An ultrasonic immersion method is presented for the rapid and accurate measurement of longitudinal sound velocity (v) in polyethylene (PE). The method is based solely on the measurement of time delays and can be automated. The samples are the same press‐molded plaques that are prepared for the standard‐density (ρ) determination using a density‐gradient column, Our measurements on a representative group of various types of PE with densities in the range 0.92 to 0.96 g/cm 3 show without ambiguity that v is proportional to ρ. The degree of correlation is such that we come to suggest that the acoustic method be used for the characterization of density. We show that the accuracy is good and compares with that of the density‐gradient column and we then conclude on the practical advantages of the ultrasonic method.
Towards Quantum Key Distribution System using Homodyne Detection with Differential Time-Multiplexed Reference (2007)

In this work we present the principles and experimental demonstration of a BB84 quantum key distribution (QKD) one way system using fainted pulses and a quadrature phase-shift-keying (QPSK) format including a time- multiplexed unmodulated carrier reference at Alice's end, and a differential homodyne reception at Bob's end. We also describe the secure electronics interface subsystem concept for the interaction with upper layers in an IP application.
Adaptive precision in texture mapping (1986)

We introduce an adaptive, iterative technique for obtaining texture samples of arbitrary precision when synthesizing a computer-generated image. The technique is an improvement on the sum table texturing method. To motivate the technique we analyze the error properties of the sum-table method. Based on that analysis we propose using a combination of tables independently or together to obtain a better estimate, and analyze the error properties of such methods. We then propose a new technique for obtaining texture samples whose accuracy is a function of the texture and the image. As part of this technique we propose the use of an auxiliary table which contains local estimates of the texture variance. We show how the iteration of a given sample may be controlled by values from this table. We then analyze the error in this method, and present images which demonstrate the improvement.
Experiences with networked parallel computing (1995)

Abstract The performance and proliferation of workstations continues to increase at a rapid rate. However, the practical utilization of workstation networks for parallel computing is still in its infancy. This is due to the relative immaturity of programming tools, low bandwidth networks such as Ethernet, and high message latencies. However, programming tools are becoming more mature and network bandwidths are increasing rapidly. Hence, networks of commodity workstations may prove to be practical for certain classes of parallel applications. This paper describes our experiences with two applications parallelized on a network of Sun workstations. The first application is from Shell's petroleum engineering department. This program quantitatively derives rock and porefill composition from well‐log data, using a compute‐intensive iterative optimization procedure. The second application is time filtering, which is a fundamental operation performed on seismic traces. Through our experiments we identify the limits of networked parallel computing based on the current state of network technology. We also provide a discussion on the possible impact of future high speed networks on networked parallel computing.
Hydrophobic interaction chromatography: harnessing multivalent protein-surface interactions for purification procedures. (2005)

Hydrophobic interaction chromatography (HIC) is one of the basic purification procedures in the biosciences. However, because of its complexity, it has not gained the same foothold in the methodological repertoire of protein chemistry as has affinity chromatography or ion exchange chromatography. This is mainly a result of the lack of a general optimization procedure for the reversible adsorption and elution of a novel protein to be purified. Further problems arise from the fact that most commercial hydrophobic adsorbents are inadequate for an ideal performance in downstream processing procedures, because these media are too hydrophobic and elution of proteins in their native state is often impossible. Therefore, as in the 1970s, a bioscientist of today has to be capable of synthesizing a small library of hydrophobic gels from which he or she can then select and optimize the ideal matrix for their special needs. In addition, a general optimization method employing the critical hydrophobicity concept has now been devised that should allow the application of HIC methodology to many hitherto unpurified proteins. In this chapter, the reader is first introduced to the theoretical background (multivalence, negative cooperativity, adsorption hysteresis) of the binding of protein ligands to hydrophobic supports, so that they will be capable of independently adapting HIC to a novel protein. Then a simple nontoxic method is described for the synthesis of HIC-gel libraries consisting of a homologous series of uncharged alkyl-Sepharoses of three chain lengths (butyl, pentyl, and hexyl Sepharose) prepared with different degrees of separation. From this series a critical hydrophobicity gel can then be selected and employed for critical hydrophobicity HIC. A detailed example for the chromatography of human fibrinogen is given that has been employed as a one-step procedure for the purification of fibrinogen from human plasma.