gebhart/patrepeval huggingface dataset:
Strain-dependent sequence heterogeneity in the nuclear group I introns and large subunit ribosomal RNA in<i>Physarum polycephalum</i> (1991)

The DNA sequence of an internal EcoRI fragment in the large subunit ribosomal RNA gene from the myxomycete Physarum polycephalum, strain M3C, has been determined. This ribosomal DNA fragment contain two group I introns. Sequence heterogeneity in the two introns and in the coding region of the ribosomal RNA were identified upon comparison to the strain PPO-1 sequence. The nature of the sequence variations is discussed.
Soil Mechanics for Unsaturated Soils (1993)

Keywords: Mecanique des sols ; Sols non satures Reference Record created on 2004-09-07, modified on 2016-08-08
Digital Signal Processing Methods for Pixelated 3-D Position Sensitive Room-Temperature Semiconductor Detectors (2012)

CdZnTe detectors have been developed since 1990s cite{CZTHistory1, CZTHistory2, CZTHistory3, CZTHistory4, IEEE:CoplanarGrid, newsemi4}. They have shown great potential to be one of the room-temperature substitutes of traditional HPGe detectors. Many efforts have been made to make CdZnTe detectors to approach the theoretical 0.2 % FWHM energy resolution at 662 keV. The 3-D position-sensitive pixelated CdZnTe detectors have demonstrated 0.48 % energy resolution when the electronic noise is low, which is close to the theoretical limit. However, current ASICs that only read out the signal amplitude and timing information have several limitations, which placed obstacles on further improvement of the performance of CdZnTe detectors, especially for multi-pixel and high-energy events. In order to overcome those limitations, a new digital ASIC, which is capable of read out pre-amplifier pulse waveforms is developed. This thesis presents several signal processing techniques base on this digital ASIC. First, the electronic noise and its characteristics is studied and discussed. A new fitting method utilizing the characteristics of noise is presented and its performance is demonstrated. Then, a new position sensing technique that presents sub-pixel lateral position resolution is discussed. The improvement of angular resolution of Compton imaging from 37 degree to 34 degree for polar angle and 23 degree to 17 degree for azimuthal angle after employing such an algorithm is achieved. The potential of using sub-pixel position sensing to further improve energy resolution is depicted. Finally, a new energy and position reconstruction algorithm based on the concept of system response function is described. The method to generate system response function is presented. Several benefits of the system response function fitting algorithm is demonstrated.
Application of improved artificial immune network algorithm to optimization (2008)

Tabu search artificial immune algorithm (TS-aiNet) is proposed based on aiNet inspired by mechanism of tabu search algorithm. It introduced a tabu list that taboos cells whose affinities didnpsilat increase no longer in the network. In some phrase the tabooed excellent cells were released according to aspiration criteria. It added a memory table applied to save mature memory cells. Moreover it improved the expression of Gauss mutation for diversity search in the process of global optimization. Markov chain was applied to prove global convergence. Convergence analysis was based on random simulation of some typical systems and compared with that of CLONALG and aiNet algorithms. The simulation results show that the presented approach has preferable global convergent ability and stability in multi-modal search space, and can avoid prematurity effectively. So it is demonstrated a global optimized algorithm with feasible and high efficiency.
Comparative Study of the In Vitro Antibacterial Activity of Cefoxitin, Cefuroxime, and Cephaloridine (1976)

The in vitro antibacterial effects of cefoxitin, a semisynthetic cephamycin, cefuroxime, a new cephalosporin antibiotic, and cephaloridine were compared. With gram-positive bacteria, marked differences were found only in the effects against Streptococcus faecalis, where cephaloridine and cefuroxime were superior to cefoxitin. With gram-negative aerobic bacteria, cefoxitin, which is known to be more resistant to beta-lactamases from gram-negative bacteria than any cephalosporin, was found to be more effective than cefuroxime and cephaloridine against ampicillin-resistant strains of Escherichia coli and indole-positive strains of Proteus. Haemophilus influenzae was found to be more susceptible to cefuroxime than to cefoxitin and cephaloridine. When ampicillin-resistant strains of H. influenzae were tested, markedly higher minimal inhibitory concentration values were obtained with cephaloridine in comparison to those obtained with ampicillin-susceptible strains. These increases in the minimal inhibitory concentration values were not observed with cefoxitin and cefuroxime, probably due to the resistance of these two compounds to beta-lactamases. Strains of Bacteroides fragilis were found to be much more susceptible to cefoxitin than to cefuroxime, which in turn was superior to cephaloridine. The results obtained indicate that cefoxitin and cefuroxime both are superior in their antibacterial spectra to the cephalosporins that are now in clinical use.
Constructing hierarchies for triangle meshes (1998)

We present a method to produce a hierarchy of triangle meshes that can be used to blend different levels of detail in a smooth fashion. The algorithm produces a sequence of meshes M/sub 0/, M/sub 1/, M/sub 2/..., M/sub n/, where each mesh M/sub i/ can be transformed to mesh M/sub i+1/ through a set of triangle-collapse operations. For each triangle, a function is generated that approximates the underlying surface in the area of the triangle, and this function serves as a basis for assigning a weight to the triangle in the ordering operation and for supplying the points to which the triangles are collapsed. The algorithm produces a limited number of intermediate meshes by selecting, at each step, a number of triangles that can be collapsed simultaneously. This technique allows us to view a triangulated surface model at varying levels of detail while insuring that the simplified mesh approximates the original surface well.
Isolation and Characterization of a Phenolic Antioxidant from the Pacific Oyster (Crassostrea gigas) (2011)

Using an oxygen radical absorbance capacity (ORAC) assay, antioxidant activity was detected in the ethanol extract of the Pacific oyster, which was purified by sequential extraction with organic solvents. The ethyl acetate fraction showed the strongest antioxidant activity and was further purified, yielding a single compound [as assessed by thin-layer chromatography (TLC) and reverse-phase high-performance liquid chromatography (HPLC)]. This compound was identified as 3,5-dihydroxy-4-methoxybenzyl alcohol on the basis of (1)H and (13)C nuclear magnetic resonance (NMR), heteronuclear multiple-bond correlation (HMBC), and electrospray ionization-mass spectrometry (ESI-MS) spectral analyses, a conclusion that was confirmed by chemical synthesis. The concentration of the compound was 6.7 mg/100 g of whole oyster meat wet weight. This amphiphilic antioxidant retarded the copper-mediated oxidation of low-density lipoproteins (LDLs) and the generation of thiobarbituric acid reactive substances. Furthermore, the compound showed substantial antioxidant activity using the ORAC and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays compared to natural antioxidants. Although the same compound was previously found in brown algae, its presence in other organisms and antioxidant activity are reported here for the first time.
In-place versus re-build versus re-merge: Index maintenance strategies for text retrieval systems (2004)

Attempts to categorise music by extracting audio features from a sample have had mixed results. Some categories such as classical are easy to identify but attempts to distinguish between various types of popular music yield poor results. Part of the difficulty is that humans also disagree with each other when classifying music. We report on experiments that compare human classification of music samples to that based on audio feature extraction and machine learning techniques. We extracted a set of audio features and applied a range of machine learning techniques to a set of 128 pieces of music. Our work demonstrates that a single feature and a simple machine learning approach achieve results that are almost as consistent as humans for the same task. Further experiments revealed an even greater inconsistency amongst humans in selecting categories for music. Using a self-organising map on the same set of pieces and features produced some meaningful song clusters, that is, pieces by the same artist or composer, or of the same genre, were grouped together. It also showed some of the same cross-genre relationships shown by the human-based classifications
Microchannel fluid behavior using micropolar fluid theory (2002)

In this paper, we describe microchannel fluid behavior using a numerical model based on micropolar fluid theory and experimentally verify the model using micromachined channels. The micropolar fluid theory augments the laws of classical continuum mechanics by incorporating the effects of fluid molecules on the continuum. The behavior of fluids was studied using surface micromachined rectangular metallic pipette arrays. A downstream port for static pressure measurement was used to eliminate entrance effects. The numerical model of the micropolar fluid theory compares favorably with the experimental data.
Theophylline-induced protection in myoglobinuric acute renal failure: further characterization (1987)

We have reported previously that aminophylline has an ameliorating effect on the course and severity of glycerol-induced myoglobinuric acute renal failure in rats. Since aminophylline dissociates into theophylline in biological fluids and since theophylline is an adenosine receptor antagonist, we attributed the ameliorating effects to antagonism of the hemodynamic effects of endogenous adenosine. However, theophylline blocks tubuloglomerular feedback and produces natriuresis, and either of these effects might have accounted for the beneficial effects in acute renal failure. Therefore, this study was designed to further characterize the effects of theophylline in glycerol-induced acute renal failure in rats. Aminophylline had dose-dependent beneficial effects, as judged by the peak serum creatinine during the 3 days following induction of acute renal failure, by the number of animals with peak serum creatinine greater than 1 mg/dL, and by the mortality rate. Both furosemide and theophylline block tubuloglomerular feedback and produce natriuresis, but aminophylline had protective effects, whereas furosemide actually increased mortality, compared with aminophylline, following induction of myoglobinuric acute renal failure. Therefore, aminophylline's protective effects are independent of tubuloglomerular feedback and natriuresis. These results offer further support for the hypothesis that adenosine-induced hemodynamic changes play a pathogenic role in glycerol-induced acute renal failure in rats.
Search engines tackle the desktop (2005)

As PC hard drives get bigger and new information sources become available, users will have much more data of different types, including multimedia, on their computers. This makes it increasingly difficult to find documents, e-mail messages, spreadsheets, audio clips, and other files. Current desktop-based search capabilities, such as those in Windows, are inadequate to meet this challenge. Desktop search features built into current operating systems, e-mail programs, and other applications have far fewer capabilities than Web search engines. They generally offer only simple keyword searches of a set of files, usually of a single file type. However, desktop search engines face the additional challenge of recognizing which of the many file types it is dealing with. The engines also must derive whatever metadata authors have chosen to include in e-mail notes, database files, and other document types. Desktop engines must be efficient and avoid imposing a substantial processing or memory load on the computer. Integrating desktop and Web search capabilities into the same application presents security and privacy challenges.
Effect of Acute Sympathectomy on Responses to Angiotensin and Norepinephrine (1962)

The vasopressor response to angiotensin administered intra-arterially to the perfused hindquarters of the dog was reduced significantly after acute sympathectomy. Responses to norepinephrine and tyramine remained unchanged. Similar results were obtained following gangliouic blockade with hexamethonium and cervical spinal transection. After the response to augiotensin was reduced following sympathectomy, the cut lumbar sympathetic nerves were stimulated electrically. During the period of stimulation, an increase in the vasoconstrictor effect to angiotensin was obtained, but complete restoration to the control magnitude was not seen consistently. Possible mechanisms for the reduction in the response to angiotensin following sympathectomy are discussed. The present evidence suggests that the tonic discharge of normally functioning sympathetic nerves is capable of facilitating the response to angiotensin and that sympathectomy results in an abolition of this effect.
Welding thermoplastic elastomers to polypropylene with a diode laser (2002)

The process of welding thermoplastic elastomers to polypropylene using scanning transmission laser welding was studied. Thermoplastic rubber plaques of various durometers were welded to 30% glass-filled polypropylene using a 150 W diode laser. In transmission laser welding, one of the materials is transmissive to the laser and one absorbs the laser. In this study the elastomers were used as the transmissive material in some trials and as the absorbing material in others. Hence the polypropylene plaque was the absorbing material in the former trials and as the transmissive material in the latter. The effect of the laser welding parameters on weld quality, width and strength was studied. The laser welding parameters investigated were power, scanning speed, beam spot size, and clamp pressure. Weld strength was determined by tensile testing of the resulting shear lap samples. Implications of the effects of parameter changes on weld quality and on failure mode are discussed.
Use of a Macrocyclic Antibiotic as the Chiral Selector for Enantiomeric Separations by TLC (1994)

Abstract The macrocyclic antibiotic, vancomycin, was used as a chiral mobile phase additive for the thin layer chromatographic (TLC) resolution of 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) derivatized amino acids, racemic drugs and dansyl-amino acids. Excellent separations were achieved for most of these compounds in the reversed phase mode. Both the nature of the stationary phase and the composition of the mobile phase strongly influenced enantiomeric resolution. The best results were obtained using diphenyl stationary phases. Acetonitrile was the organic modifier that produced the most effective separations with the shortest development times. It is highly likely that macrocyclic antibiotics will play a major role in future enantiomeric separations.
Amino Acid Limitation and Flow to the Duodenum at Four Stages of Lactation. 2. Extent of Lysine Limitation (1992)

Four multiparous Holstein cows with ruminal and duodenal cannulas were assigned to 4 x 4 Latin squares at peak (wk 4), early (wk 14 to 16), mid (wk 21 to 23), and late (wk 29 to 31) lactation to determine, in the presence of supplemental Met, the extent of Lys limitation and its required contribution to total essential AA in duodenal digesta. Treatments were duodenal infusions of 1) water alone or water with 2) 10 g/d of DL-Met plus 10 g/d of L-Lys, 3) 10 g/d of Met plus 20 g/d of Lys, and 4) 10 g/d of Met plus 30 g/d of Lys; quantities were reduced by 20% in late lactation. Rations were corn based (corn and grass-legume silages, corn meal, wheat middlings, soybean meal, and distillers dried grains with solubles) and most limiting in Lys and Met. Intakes of ruminally degraded and undegraded intake protein (percentage of NRC requirements) were (peak) 115, 97; (early) 112, 83; (mid) 113, 87; and (late) 127, 96. Contribution of Lys to passage of total essential AA to the duodenum without infusions were 13.2, 12.4, 13.8, and 14.8% at the four respective stages of lactation. Extent of Lys limitation determined from responses in content and yield of milk protein approximated 25, 20, and 10 g/d during peak, early, and midlactation.(ABSTRACT TRUNCATED AT 250 WORDS)
It's Time to Think About an Operating System for Near Data Processing Architectures (2017)

research-article Share on It's Time to Think About an Operating System for Near Data Processing Architectures Authors: Antonio Barbalace Huawei German Research Center Huawei German Research CenterView Profile , Anthony Iliopoulos Huawei German Research Center Huawei German Research CenterView Profile , Holm Rauchfuss Huawei German Research Center Huawei German Research CenterView Profile , Goetz Brasche Huawei German Research Center Huawei German Research CenterView Profile Authors Info & Claims HotOS '17: Proceedings of the 16th Workshop on Hot Topics in Operating SystemsMay 2017 Pages 56–61https://doi.org/10.1145/3102980.3102990Published:07 May 2017Publication History 17citation1,298DownloadsMetricsTotal Citations17Total Downloads1,298Last 12 Months108Last 6 weeks13 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Single compound forming a lyotropic liquid crystal at room temperature (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSingle compound forming a lyotropic liquid crystal at room temperatureStig E. Friberg, Paul Liang, Frances E. Lockwood, and Maher TadrosCite this: J. Phys. Chem. 1984, 88, 5, 1045–1046Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://pubs.acs.org/doi/10.1021/j150649a039https://doi.org/10.1021/j150649a039research-articleACS PublicationsRequest reuse permissionsArticle Views184Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Apolipoprotein E forms stable complexes with recombinant Alzheimer's disease <i>β</i>-amyloid precursor protein (1997)

Apolipoprotein E (apoE), a protein genetically linked to the incidence of Alzheimer's disease, forms SDS-stable complexes in vitro with beta-amyloid peptide (Abeta), the primary component of senile plaques. In the present study, we investigated whether apoE was able to bind full-length Abeta precursor protein (APP). Using a maltose-binding-protein-APP fusion protein and human very-low-density lipoprotein (VLDL), we detected an interaction of apoE with APP that was inhibited by Abeta or anti-apoE antibody. Saturation-binding experiments indicated a single binding equilibrium with an apparent 1:1 stoichiometry and a dissociation constant of 15 nM. An interaction was also observed using apoE from cerebrospinal fluid or delipidated VLDL, as well as recombinant apoE. APP.apoE complexes were SDS-stable, and their formation was not inhibited by reducing conditions; however, they were dissociated by SDS under reducing conditions. ApoE.APP complexes formed high-molecular-mass aggregates, and competition experiments suggested that amino acids 14-23 of Abeta are responsible for complex-formation. Finally, no differences were found when studying the interaction of APP with apoE3 or apoE4. Taken together, our results demonstrate that apoE may form stable complexes with the Abeta moiety of APP with characteristics similar to those of complexes formed with isolated Abeta, and suggest the intriguing possibility that apoE-APP interactions may be pathologically relevant in vivo.
Genomic instability of microsatellite repeats in prostate cancer: relationship to clinicopathological variables. (1995)

Sixty-six patients with prostatic adenocarcinoma were screened for somatic instability at 8 microsatellite marker loci on 5 chromosomes. Differences in unrelated microsatellites for tumor and normal DNA were detected in 13 (19.7%) patients. Only extraglandular spread (nodal involvement and distant metastasis) was found to show significant association with somatic instability after controlling for other clinicopathological variables (P < 0.05). Microsatellite instability may possibly occur during the early stages of neoplastic transformation in a subset of prostate cancer rather than as a late event. This may be related to a phenotype with growth advantage. The frequency of this mutator phenotype is much higher in the United States than Japan, reflecting racial differences in the molecular tumorigenesis of this malignancy.