gebhart/patrepeval huggingface dataset:
Interaction of Human Arp2/3 Complex and the <i>Listeria monocytogenes</i> ActA Protein in Actin Filament Nucleation (1998)

Actin filament assembly at the cell surface of the pathogenic bacterium Listeria monocytogenes requires the bacterial ActA surface protein and the host cell Arp2/3 complex. Purified Arp2/3 complex accelerated the nucleation of actin polymerization in vitro, but pure ActA had no effect. However, when combined, the Arp2/3 complex and ActA synergistically stimulated the nucleation of actin filaments. This mechanism of activating the host Arp2/3 complex at the L. monocytogenes surface may be similar to the strategy used by cells to control Arp2/3 complex activity and hence the spatial and temporal distribution of actin polymerization.
Computer search for binary cyclic UEP codes of odd length up to 65 (1990)

Exhaustive computation by a computer was used to find the unequal error protection capabilities of all binary cyclic codes of odd length up to 65 that have minimum distances of at least 3. For those codes for which upper bounds can only be computed on their unequal error protection capabilities, an analytic method developed by V.N. Dynkin and V.A. Togonidze (1976) is used to show that the upper bounds meet the exact unequal error protection capabilities.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Vector-beam solutions of Maxwell’s wave equation (1996)

The Hermite-Gauss and Laguerre-Gauss modes are well-known beam solutions of the scalar Helmholtz equation in the paraxial limit. As such, they describe linearly polarized fields or single Cartesian components of vector fields. The vector wave equation admits, in the paraxial limit, of a family of localized Bessel-Gauss beam solutions that can describe the entire transverse electric field. Two recently reported solutions are members of this family of vector Bessel-Gauss beam modes.
A Critical Role for Ceramide Synthase 2 in Liver Homeostasis (2010)

Ceramide is an important lipid signaling molecule that plays critical roles in regulating cell behavior. Ceramide synthesis is surprisingly complex and is orchestrated by six mammalian ceramide synthases, each of which produces ceramides with restricted acyl chain lengths. We have generated a CerS2 null mouse and characterized the changes in the long chain base and sphingolipid composition of livers from these mice. Ceramide and downstream sphingolipids were devoid of very long (C22-C24) acyl chains, consistent with the substrate specificity of CerS2 toward acyl-CoAs. Unexpectedly, C16-ceramide levels were elevated, and as a result, total ceramide levels were unaltered; however, C16-ceramide synthesis in vitro was not increased. Levels of sphinganine were also significantly elevated, by up to 50-fold, reminiscent of the effect of the ceramide synthase inhibitor, fumonisin B1. With the exceptions of glucosylceramide synthase and neutral sphingomyelinase 2, none of the other enzymes tested in either the sphingolipid biosynthetic or degradative pathways were significantly changed. Total glycerophospholipid and cholesterol levels were unaltered, although there was a marked elevation in C18:1 and C18:2 fatty acids in phosphatidylethanolamine, concomitant with a reduction in C18:0 and C20:4 fatty acids. Finally, differences were observed in the biophysical properties of lipid extracts isolated from liver microsomes, with membranes from CerS2 null mice displaying higher membrane fluidity and showing morphological changes. Together, these results demonstrate novel modes of cross-talk and regulation between the various branches of lipid metabolic pathways upon inhibition of very long acyl chain ceramide synthesis.
Tracking Variable Number Of Targets Using Sequential Monte Methods (2005)

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005
Forward telescoping bias in reported age of onset: an example from cigarette smoking (2005)

Age at the onset of a disorder is one of its key descriptive characteristics. Early onset may indicate increased risk of a severe course and increased genetic liability. However, retrospectively reported onset in surveys is subject to forward telescoping, a bias in which respondents report events closer to the time of interview than is true. We examined the effect of this bias on age of onset for smoking initiation and daily smoking. Data came from the 1966-77 birth cohorts interviewed in the cross-sectional National Household Surveys on Drug Abuse (NHDSA) 1979-98 (N = 82,122). An association between age at onset and age at interview, within birth year, was found for experimenters and for daily smokers. This was indicative of forward telescoping. As age at interview increased from 12 to 25 the probability of reporting early onset dropped by half. An association was also found between early onset of daily smoking and age at interview. This response bias differed significantly by sex and race, created significant misclassification of smokers as late instead of early onset cases, and biased cohort comparisons from cross-sectional data. These results suggest efforts need to be made to limit the effect of forward telescoping in epidemiological studies by survey question and sampling design.
Screen printed PZT/PZT thick film bimorph MEMS cantilever device for vibration energy harvesting (2011)

We present a MEMS-based PZT/PZT thick film bimorph vibration energy harvester with an integrated silicon proof mass. The most common piezoelectric energy harvesting devices utilize a cantilever beam of a non piezoelectric material as support beneath or in-between the piezoelectric material. It provides mechanical support but it also reduces the power output. Our device replaces the support with another layer of the piezoelectric material, and with the absence of an inactive mechanical support all of the stresses induced by the vibrations will be harvested by the active piezoelectric elements.
[Wettability of whole milk powder and the free fat content]. (1974)

Eine Analyse an 24 Proben frischen Spruhmilchpulvers mit 25% Fett (je 4 Proben aus 6 ausgewahlten Herstellungsbetrieben, entnommen im Winter 1972/73) ergab, das zwischen der sog. Benetzbarkeit des Pulvers (bestimmt nach Radema u. a.) und der Menge an freiem Fett (freie Glyzeride in Prozent des Gesamt-Fettgehalts) eine deutliche, umgekehrt proportionale Beziehung von hyperbolischem Typ besteht. Die „Benetzbarkeit” des Pulvers lag zwischen 4,0 und 37,7%, der Gehalt an freiem Fett zwischen 3,4 und 51,0%. In 2 Betrieben wies das Milchpulver eine im allgemeinen relativ hohe „Benetzbarkeit” und einen niedrigen Gehalt an freiem Fett auf, wahrend bei den Proben aus den ubrigen 4 Betrieben ein umgekehrtes Verhaltnis festgestellt wurde.
Optimization of<i>Salmonella enterica</i>Serovar Typhi Δ<i>aroC</i>Δ<i>ssaV</i>Derivatives as Vehicles for Delivering Heterologous Antigens by Chromosomal Integration and In Vivo Inducible Promoters (2004)

Novel candidate live oral vaccines based on a Salmonella enterica serovar Typhi ZH9 (Ty2 DeltaaroC DeltassaV) derivative that directed the expression of either the B subunit of Escherichia coli heat-labile toxin or hepatitis B virus core antigen from the bacterial chromosome using the in vivo inducible ssaG promoter were constructed. The levels of attenuation of the two S. enterica serovar Typhi ZH9 derivatives were similar to that of the parent as assessed by measuring the replication of bacteria within human macrophage-like U937 cells. The expression of heterologous antigen in the respective S. enterica serovar Typhi ZH9 derivatives was up-regulated significantly within U937 cells compared to similar S. enterica serovar Typhi ZH9 derivative bacteria grown in modified Luria-Bertani broth supplemented with aromatic amino acids. Immunization of mice with these S. enterica serovar Typhi ZH9 derivatives stimulated potent antigen-specific serum immunoglobulin G responses to the heterologous antigens.
Properties of dephosphorylated α<sub>s1</sub>-casein. Precipitation by calcium ions and micelle formation (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProperties of dephosphorylated αs1-casein. Precipitation by calcium ions and micelle formationElizabeth W. Bingham, Harold M. Farrell, and Robert J. CarrollCite this: Biochemistry 1972, 11, 13, 2450–2454Publication Date (Print):June 20, 1972Publication History Published online1 May 2002Published inissue 20 June 1972https://pubs.acs.org/doi/10.1021/bi00763a010https://doi.org/10.1021/bi00763a010research-articleACS PublicationsRequest reuse permissionsArticle Views341Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sensor head development for mid-infrared fibre-optic underwater sensors (2002)

In the process of developing a mid-infrared fibre-optic sensor for operation in the marine environment, a number of parameters influencing the sensor performance have to be taken into consideration. Optical engineering and spectroscopy are the key sciences when designing an optical sensor. Other disciplines strongly influencing the design considerations for this application are marine engineering and hydrodynamics.
THE INTRODUCTION OF HIER ARCHICAL STRUCTURE AND APPLICATION SECURITY TO J AVA WEB START DEPLOYMENT (2005)

The Beam Diagnostics and Instrumentation software section is responsible for providing all the software necessary to develop, test, diagnose and maintain the different instruments produced for the CERN accelerator complex. Almost all graphical user interface applications are nowadays written in Java and the Java Web Start architecture is used to launch these applications. Java Web Start provides a solid basis for application deployment, but lacks several key features essential for ensuring a proper and easily manageable working environment (for example the lack of configuration templates and a security mechanism). This paper describes an internally developed tool, which extends the Java Web Start functionality in order to provide these missing features.
Hot Filament Chemical Vapor Deposition of Polyoxymethylene as a Sacrificial Layer for Fabricating Air Gaps (2001)

A method for synthesizing polyoxymethylene (POM) film at high deposition rates was achieved via hot filament chemical vapor deposition (HFCVD). Nuclear magnetic resonance spectra show that the structure of the polymer is linear, rather than cross-linked (which plasma enhanced CVD would have produced). The linear structure is responsible for its ease of decomposition at less than 300°C and leaving behind negligible residue. Thus, the HFCVD POM film is proposed as a novel sacrificial layer for fabricating air gaps, as it could offer the advantages of shorter removal time, decreased heat load, and ease of process integration over conventional methods and materials. © 2001 The Electrochemical Society. All rights reserved.
Alkynes as Stille Reaction Pseudohalides:  Gold- and Palladium-Cocatalyzed Synthesis of Tri- and Tetra-Substituted Olefins (2008)

A Stille-type reaction that employs alkynes as pseudohalides provides access to the catalytic chemistry of palladium−carbon σ-bonds starting from π-systems. The synthesis of a variety of tri- and tetra-substituted olefins by addition of sp2- and sp-hybridized stannanes across mono- and diester alkynes was accomplished with complete regioselectivity and high stereoselectivity. The reaction is proposed to proceed via a bimetallic mechanism where the Lewis acidic Au(I) activates the alkyne toward oxidative addition across Pd(0).
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. (2002)

We examined the relationship between aberrant DNA hypermethylation and key histone code components at a hypermethylated, silenced tumor suppressor gene promoter in human cancer. In lower eukaryotes, methylated H3-lysine 9 (methyl-H3-K9) determines DNA methylation and correlates with repressed gene transcription. Here we show that a zone of deacetylated histone H3 plus methyl-H3-K9 surrounds a hypermethylated, silenced hMLH1 promoter, which, when unmethylated and active, is embedded in methyl-H3-K4 and acetylated H3. Inhibiting DNA methyltransferases, but not histone deacetylases, leads first to promoter demethylation, second to gene reexpression, and finally to complete histone code reversal. Our findings suggest a new paradigm-DNA methylation may directly, or indirectly by inhibiting transcription, maintain key repressive elements of the histone code at a hypermethylated gene promoter in cancer.
Serum Lipoprotein in Active Rheumatoid Arthritis and Other Chronic Inflammatory Arthritides (1987)

Serum lipids and lipoprotein patterns were prospectively analyzed in 33 previously untreated patients with active chronic inflammatory arthritides during different anti-inflammatory and disease-modifying drug regimens. Before treatment the lipoprotein pattern was characterized by low cholesterol concentrations in all lipoprotein fractions and low triglyceride concentrations in the very-low-density lipoprotein fraction as well as in the high-density lipoprotein fraction. During treatment with prednisolone combined with azathioprine or cyclophosphamide (n = 10), a reduction of the disease activity was achieved and the lipoprotein pattern was normalized; similar results were noted in a small group of patients (n = 4) treated with prednisolone alone while nonsteroidal anti-inflammatory drug therapy (n = 9) neither significantly affected the lipoprotein pattern nor the inflammatory activity measured by the acute-phase reactants. The long-term treatment with penicillamine (n = 4) and chloroquine (n = 6) induced both a clinical remission of the disease and a reduction of the inflammatory activity. The lipoprotein concentrations started to reverse to the normal values during penicillamine treatment. In contrast, in the chloroquine-treated group the alterations in lipoprotein lipid concentrations were further pronounced, ie, the cholesterol and triglyceride concentrations in serum and the very-low-density lipoprotein fraction decreased.
Ferroverdins, Inhibitors of Cholesteryl Ester Transfer Protein Produccd by Streptomyces sp. WK-5344. I. Production, Isolation and Biological Properties. (1999)

Streptomyces sp. WK-5344, a soil isolate, was found to produce structurally related inhibitors of cholesteryl ester transfer protein (CETP). New active compounds, designated ferroverdins B and C, were isolated along with known ferroverdin A from the fermentation broth by solvent extraction, ODS column chromatography and silica gel column chromatography. All ferroverdins showed a dose-dependent inhibitory activity against human CETP. The IC50 values were 21, 0.62 and 2.2 microM for ferroverdins A, B and C, respectively, indicating that ferroverdin B is one of the most potent CETP inhibitors of microbial origin.
Investigation of Contact Metallization Systems for Solar Cells (1980)

In conventional solar cells, evaporated Ti‐Pd‐Ag metallization system has been found reliable. However, for low cost terrestial applications, its cost effectiveness may be questioned. Electroplated Ag and Cu have been investigated as replacements for evaporated Ag and have given results comparable to the evaporated Ti‐Pd‐Ag system.
Recycling and Disposal Methods for Polyurethane Foam Wastes (2012)

With the wide application of polyurethane foam materials, a large number of polyurethane foam wastes need to be disposed. There are mainly three types of disposal technology, landfill, incineration and recycling in the world. In this paper, through comprehensive comparison, recycling is the most desirable way. Physical recycling method, due to the simple operation and relatively active application, in the short term is an effective means. Chemical recycling method, due to its higher technical difficulty, is difficult to realize large-scale industrialized production in the short term. And in the future, recovery utilization is the ultimate method.
General Method for Functionalized Polyaryl Synthesis via Aryne Intermediates (2014)

A method for base-promoted arylation of arenes and heterocycles by aryl halides and aryl triflates is described. Additionally, in situ electrophilic trapping of ArLi intermediates generated in the reaction of benzyne with deprotonated arenes or heterocycles has been developed, providing rapid and easy access to a wide range of highly functionalized polyaryls. Base-promoted arylation methodology complements transition-metal-catalyzed direct arylation and allows access to structures that are not easily accessible via other direct arylation methods. The reactions are highly functional-group tolerant, with alkene, ether, dimethylamino, trifluoromethyl, ester, cyano, halide, hydroxyl, and silyl functionalities compatible with reaction conditions.
Robust Filtering Under Randomly Varying Sensor Delay With Variance Constraints (2004)

This paper deals with a new filtering problem for linear uncertain discrete-time stochastic systems with randomly varying sensor delay. The norm-bounded parameter uncertainties enter into the system matrix of the state space model. The system measurements are subject to randomly varying sensor delays, which often occur in information transmissions through networks. The problem addressed is the design of a linear filter such that, for all admissible parameter uncertainties and all probabilistic sensor delays, the error state of the filtering process is mean square bounded, and the steady-state variance of the estimation error for each state is not more than the individual prescribed upper bound. We show that the filtering problem under consideration can effectively be solved if there are positive definite solutions to a couple of algebraic Riccati-like inequalities or linear matrix inequalities. We also characterize the set of desired robust filters in terms of some free parameters. An illustrative numerical example is used to demonstrate the usefulness and flexibility of the proposed design approach.
Efficient use of the grammar scale factor to classify incorrect words in speech recognition verification (2002)

The goal of verification in speech recognition systems is to detect words in the hypothesized sentence that are likely to have been misrecognized. This decision can be based on the persistence of the different words in the output of the speech recognizer when some recognition parameter is varied. To this end, a parameter that proves particularly adequate is the so called grammar scale factor (which balances acoustic and language model scores). The main disadvantage of this method is that it needs to repeat the recognition process many times. In the paper, after formulating it as a statistical pattern classification problem, we show how to speed-up this method, so that less than two average repetitions of the recognition process are enough to achieve essentially the same verification performance as with the many more repetitions needed by the original proposal.
Vaccination against the Forkhead Family Transcription Factor Foxp3 Enhances Tumor Immunity (2007)

Depletion of CD4+CD25+ regulatory T cells (Treg) by treatment with alphaCD25 antibody synergizes with vaccination protocols to engender protective immunity in mice. The effectiveness of targeting CD25 to eliminate Treg is limited by the fact that CD25, the low-affinity interleukin-2 receptor, is up-regulated on conventional T cells. At present, foxp3 is the only product known to be exclusively expressed in Treg of mice. However, foxp3 is not expressed on the cell surface and hence cannot be targeted with antibodies. In this study, we tested the hypothesis that vaccination of mice against foxp3, a self-antigen expressed also in the thymus, is capable of stimulating foxp3-specific CTL that will cause the depletion of Treg and enhanced antitumor immunity. Vaccination of mice with foxp3 mRNA-transfected dendritic cells elicited a robust foxp3-specific CTL response and potentiated vaccine-induced protective immunity comparably with that of alphaCD25 antibody administration. In contrast to alphaCD25 antibody treatment, repeated foxp3 vaccination did not interfere with vaccine-induced protective immunity. Importantly, foxp3 vaccination led to the preferential depletion of foxp3-expressing Treg in the tumor but not in the periphery, whereas alphaCD25 antibody treatment led to depletion of Treg in both the tumor and the periphery. Targeting foxp3 by vaccination offers a specific and simpler protocol for the prolonged control of Treg that may be associated with reduced risk of autoimmunity, introducing an approach whereby specific depletion of cells is not limited to targeting products expressed on the cell surface.
The NON-VON Supercomputer (1982)

NON-VON is a highly parallel, non-von Neumann supercomputer, portions of which are now being implemented in the Computer Science Department at Columbia University. The machine is intended to support the extremely rapid execution of large scale data manipulation tasks, including relational database operations and many other functions relevant to commercial data processing. The NON-VON architecture includes a tree-structured Primary Processing Subsystem (PPS), which we are implementing using custom nMOS VLSI circuits, along with a Secondary Processing Subsystem (SPS) based on a bank of intelligent disk drives. A high-bandwidth parallel interface provides for rapid data transfer between the two subsystems. This paper describes the organization of the NON-VON machine, with particular emphasis on the structure and function of the PPS. Some of the most important NON-VON programming techniques are then outlined, and their application to typical data processing applications illustrated with simple examples.