gebhart/patrepeval huggingface dataset:
The Luteal Phase after GnRHa Trigger-Understanding An Enigma. (2014)

The luteal phase of all stimulated in vitro fertilization/intra-cytoplasmic sperm injection (IVF/ICSI) cycles is disrupted, which makes luteal phase support (LPS) mandatory. The cause of the disruption is thought to be the multifollicular development achieved during ovarian stimulation which results in supraphysiological concentrations of steroids se- creted by a high number of corpora lutea during the early luteal phase. This will directly inhibit luteinizing hormone (LH) secretion by the pituitary via negative feedback at the level of the hypothalamic-pituitary axis, leading to a luteal phase defect. With the intro- duction of the gonadotropin-releasing hormone (GnRH) antagonist protocol, it became feasible to trigger final oocyte maturation and ovulation with a single bolus of GnRH agonist (GnRHa) as an alternative to human chorionic gonadotropin (hCG). GnRHa trig- gering presents several advantages, including the reduction in or even elimination of ovarian hyperstimulation syndrome. Despite the potential advantages of GnRHa trig- gering, previous randomized controlled trials reported a poor clinical outcome with high rates of early pregnancy losses, despite supplementation with a standard LPS in the form of progesterone and estradiol. Following these disappointing results, several studies now report a luteal phase rescue after modifications of the LPS, resulting in a reproductive outcome comparable to that seen after hCG triggering. We herein review luteal phase dif- ferences between the natural cycle, hCG trigger and GnRHa trigger and present the most recent data on handling the luteal phase after GnRHa triggering.
The Meerkat multicomputer: tradeoffs in multicomputer architecture (1995)

The Meerkat Multicomputer: Tradeoffs in Multicomputer Architecture by Robert C. Bedichek Co-Chairpersons of Supervisory Committee: Professor Henry M. Levy Professor Edward D. Lazowska Department of Computer Science and Engineering A central problem preventing the wide application of distributed memory multicomputers has been their high price, especially for small installations. High prices are due to long design times, support for scaling to thousands of nodes, and high production costs. This thesis demonstrates a new approach that combines some carefully chosen restrictions on scaling with a software-intensive methodology. We used a concrete design, Meerkat, as a vehicle for exploring the multicomputer design space. Meerkat is a distributed memory multicomputer architecture effective in the range from several to hundreds of processors. It uses a two-dimensional, passive backplane to connect nodes composed of processors, memory, and I/O devices. The interconnect is conceptually simple...
Bias current generators with wide dynamic range (2004)

This paper describes CMOS circuits that generate a wide-ranging set of fixed bias currents, spanning at least 6 decades down to picoamperes. A master current generated by a bootstrapped current reference is successively divided by a current splitter to generate the desired references. An unpublished startup circuit and a power control mechanism are described. Measurements from a 0.35/spl mu/m implementation are presented and non-idealities are investigated. Readers are directed to a design kit that makes it simple to generate the layout for a bias generator with a set of desired currents for scalable MOSIS CMOS processes.
Occupational Skin Hazards from Synthetic Plastics (1993)

Epoxy and acrylic resins have numerous industrial applications but are also widely used in the household environment. These compounds are presently one of the most important sources of occupational contact dermatitis. Contact sensitization to epoxy resins is usually caused by the resin itself but hardeners or other additives, such as reactive diluents, plasticizers, fillers and pigments, can occasionally be responsible. Since completely cured epoxy resins are not sensitizers, epoxy resin sensitization is always due to the presence, in the final polymer, of uncured allergenic low molecular weight oligomers. Acrylates are now considered the fourth most common cause of contact sensitization due to resins. Unpolymerized monomers of acrylic compounds are known to be responsible for the contact allergy. Accelerators, inhibitors and catalysts, which are usually added to the acrylates to promote the polymerization process, can also sensitize. Both allergic and irritant contact dermatitis may be caused by exposure to epoxy or acrylic resins and their additives. Contact urticaria, allergic or irritant airborne contact dermatitis caused by volatile compounds, onychia and paronychia can also occur. From January of 1984 to May of 1992 we detected 39 cases of occupational allergic contact dermatitis to epoxy resin system substances and 11 cases of occupational contact sensitization to acrylic compounds. In our experience, the electronics industry as well as paint and glue related activities were the most important sources of epoxy sensitization. Dental materials and anaerobic sealants were found to be the most frequent acrylate sensitizers.
Combining heterogenous features for 3D hand-held object recognition (2014)

Object recognition has wide applications in the area of human-machine interaction and multimedia retrieval. However, due to the problem of visual polysemous and concept polymorphism, it is still a great challenge to obtain reliable recognition result for the 2D images. Recently, with the emergence and easy availability of RGB-D equipment such as Kinect, this challenge could be relieved because the depth channel could bring more information. A very special and important case of object recognition is hand-held object recognition, as hand is a straight and natural way for both human-human interaction and human-machine interaction. In this paper, we study the problem of 3D object recognition by combining heterogenous features with different modalities and extraction techniques. For hand-craft feature, although it reserves the low-level information such as shape and color, it has shown weakness in representing hiconvolutionalgh-level semantic information compared with the automatic learned feature, especially deep feature. Deep feature has shown its great advantages in large scale dataset recognition but is not always robust to rotation or scale variance compared with hand-craft feature. In this paper, we propose a method to combine hand-craft point cloud features and deep learned features in RGB and depth channle. First, hand-held object segmentation is implemented by using depth cues and human skeleton information. Second, we combine the extracted hetegerogenous 3D features in different stages using linear concatenation and multiple kernel learning (MKL). Then a training model is used to recognize 3D handheld objects. Experimental results validate the effectiveness and gerneralization ability of the proposed method.
Modeling and Simulation of Various Hybrid-Electric Configurations of the High-Mobility Multipurpose Wheeled Vehicle (HMMWV) (2007)

Although hybrid-electric vehicles have been studied mainly with the aim of increasing fuel economy, little has been done in order to improve both fuel economy and performance. However, vehicular-dynamic-performance characteristics such as acceleration and climbing ability are of prime importance in military vehicles such as the high-mobility multipurpose wheeled vehicle (HMMWV). This paper concentrates on the models that describe hybridized HMMWV vehicles and the simulation results of those models. Parallel and series configurations have been modeled using the advanced-vehicle-simulator software developed by the National Renewable Energy Laboratory. Both a retrofit approach and a constant-power approach have been tested, and the results are compared to the conventional model results. In addition, the effects of using smaller engines than the existing ones in hybrid HMMWV drive trains have been studied, and the results are compared to the data collected from an actual implementation of such a vehicle. Moreover, the integrated-starter/alternator (ISA) configuration has been considered, and the results were encouraging
Kir4.1 Potassium Channel Subunit Is Crucial for Oligodendrocyte Development and<i>In Vivo</i>Myelination (2001)

To understand the cellular and in vivo functions of specific K(+) channels in glia, we have studied mice with a null mutation in the weakly inwardly rectifying K(+) channel subunit Kir4.1. Kir4.1-/- mice display marked motor impairment, and the cellular basis is hypomyelination in the spinal cord, accompanied by severe spongiform vacuolation, axonal swellings, and degeneration. Immunostaining in the spinal cord of wild-type mice up to postnatal day 18 reveals that Kir4.1 is expressed in myelin-synthesizing oligodendrocytes, but probably not in neurons or glial fibrillary acidic protein-positive (GFAP-positive) astrocytes. Cultured oligodendrocytes from developing spinal cord of Kir4.1-/- mice lack most of the wild-type K(+) conductance, have depolarized membrane potentials, and display immature morphology. By contrast, cultured neurons from spinal cord of Kir4.1-/- mice have normal physiological characteristics. We conclude that Kir4.1 forms the major K(+) conductance of oligodendrocytes and is therefore crucial for myelination. The Kir4.1 knock-out mouse is one of the few CNS dysmyelinating or demyelinating phenotypes that does not involve a gene directly involved in the structure, synthesis, degradation, or immune response to myelin. Therefore, this mouse shows how an ion channel mutation could contribute to the polygenic demyelinating diseases.
The 2.3-Angstrom Structure of Porcine Circovirus 2 (2011)

Porcine circovirus 2 (PCV2) is a T=1 nonenveloped icosahedral virus that has had severe impact on the swine industry. Here we report the crystal structure of an N-terminally truncated PCV2 virus-like particle at 2.3-Å resolution, and the cryo-electron microscopy (cryo-EM) image reconstruction of a full-length PCV2 virus-like particle at 9.6-Å resolution. This is the first atomic structure of a circovirus. The crystal structure revealed that the capsid protein fold is a canonical viral jelly roll. The loops connecting the strands of the jelly roll define the limited features of the surface. Sulfate ions interacting with the surface and electrostatic potential calculations strongly suggest a heparan sulfate binding site that allows PCV2 to gain entry into the cell. The crystal structure also allowed previously determined epitopes of the capsid to be visualized. The cryo-EM image reconstruction showed that the location of the N terminus, absent in the crystal structure, is inside the capsid. As the N terminus was previously shown to be antigenic, it may externalize through viral "breathing."
Prescribed Text: Rosalie Gascoigne in Melbourne (2009)

The distinct aspects of Rosalie Gascoigne's artworks exhibited at the National Gallery of Victoria (NGV) are discussed. It is suggested that her capability for pattern recognition as evident in her arrangements such as 'Monaro' (1989), 'Feathered Fence' (1979) and 'Suddenly the Lake' (1995) are being highly appreciated by the public and art house curators.
User-network policer: a new approach for ATM congestion control (2002)

In currently proposed asynchronous transfer mode (ATM) congestion control schemes, the policing function is carried out at the network edge, which opens the possibility of cells being discarded or marked without reference to the actual message. This can lead to degradation of the service quality in the voice service or multiplication of the cell loss probability in the data service. The authors propose an approach to the policing function, called user-network policer, to resolve these problems. The scheme consists of a service-dependent user policer and a service-independent network policer. Users are responsible for policing and marking their traffic appropriately before sending them into the network. The network is only responsible for verifying the correctness of user policing and for transporting cells transparently across the network.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Large Scale Online Learning (2003)

We consider situations where training data is abundant and computing resources are comparatively scarce. We argue that suitably designed online learning algorithms asymptotically outperform any batch learning algorithm. Both theoretical and experimental evidences are presented. 1
Efficiency of the transfer of a pSAM2-derivative plasmid between two strains of Streptomyces lividans in conditions ranging from agar slants to non-sterile soil microcosms (1996)

The aim of this work was to determine the efficiency of the conjugative plasmid pTS130 to transfer in various environmental conditions between two strains of Streptomyces lividans. This plasmid is a derivative of the conjugative and integrative plasmid pSAM2 isolated originally from Streptomyces ambofaciens and capable of transfer to a large range of bacteria. Our results demonstrate the high frequency of the conjugation mechanism since more than 60% of the recipient cells developed on agar slants harbored the plasmid pTS130 (as evidenced by Southern hybridization with a pSAM2 derivative plasmid probe). When donor and recipient strains were inoculated into sterile and non-sterile soil microcosms, transconjugants were detected after two days of incubation in both cases. However, the number of donor, recipient and transconjugant cells were established at a lower level in the non-sterile soil than in the sterile soil experiments. Moreover, nutrient amendment of the sterile soil was found to increase the population levels of parental strains and transfer frequencies both significantly and simultaneously. On the other hand, modifying water potential of the soil microcosms did not result in affecting the establishment of the Streptomyces lividans cells or the transfer rate.
Expression of Human Choriogonadotropin-Like Material Correlates with Metastatic Phenotype of R3230 AC Rat Adenocarcinoma (1987)

Human choriogonadotropin (hCG)-like material has been found in variable amounts on the surface of cells of human and animal tumors. Intravenous injection of R3230 AC rat adenocarcinoma cells, one of the models investigated, results in multiple lung foci seeding. We analyzed the phenotypic diversity of this tumor by cloning and culturing two distinct cell subpopulations from a cell culture of this tumor, hereafter called OR or original cell culture. One was obtained after repeated exposure of the OR to increasing concentrations of concanavalin A and wheat germ agglutinin. A single clone was isolated and was named lectin-resistant (LR) cell line. The LR cells did not metastasize but maintained stable tumorigenicity and morphology over at least 10 passages. A second cell line was obtained by repeated passage and injection of cells from a single metastatic node. After repeating the process five times, a single clone of cells was selected from the final variant and was called lung metastatic (LM) cell line. The LM cultured cells maintained stable tumorigenicity, morphology, and metastatic properties for no more than 10 passages. OR, LR, and LM cells were assessed by their doubling time (DT), chromosome counts, and hCG immunocytochemistry. The results demonstrated that the LM cell line had a higher chromosome count than the LR and the OR cell lines, and its DT was the shortest. Immunocytochemistry of the transplanted OR neoplasm showed scattered expression of the hCG-like material. By the same techniques a complete lack of reactivity of the LR cells was found. However, almost all cells of the LM line were strongly positive for hCG-like material. After a few passages, the great majority of the LM cells also became unreactive. Our data demonstrate: (i) the existence of marked heterogeneity of the expression of hCG-like material in the primary tumor cell population; (ii) that the expression of hCG-like material correlates with the metastasizing capacity of the cells; and (iii) that there is a phenotypic instability for the expression of hCG-like material by tumor cells when maintained in vitro.
Cyclic Sulfides. I. Ultraviolet Spectra of Ethylene Sulfides (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclic Sulfides. I. Ultraviolet Spectra of Ethylene SulfidesROBERT EARL DAVISCite this: J. Org. Chem. 1958, 23, 2, 216–218Publication Date (Print):February 1, 1958Publication History Published online1 May 2002Published inissue 1 February 1958https://pubs.acs.org/doi/10.1021/jo01096a017https://doi.org/10.1021/jo01096a017research-articleACS PublicationsRequest reuse permissionsArticle Views77Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Rubiscolytics: fate of Rubisco after its enzymatic function in a cell is terminated (2007)

Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the predominant protein in photosynthesizing plant parts and the most abundant protein on earth. Amino acids deriving from its net degradation during senescence are transported to sinks (e.g. developing leaves, fruits). Rubisco catabolism is not controlled only by the overall sink demand. An accumulation of carbohydrates may also accelerate senescence and Rubisco degradation under certain conditions. Amino acids produced by proteolysis are rapidly redistributed in plants with proper source-sink relationships. In leaves of wheat plants with reduced sink capacity (e.g. sink removal, phloem interruption by steam girdling at the leaf base), Rubisco is degraded and free amino acids accumulate. They may be washed out in the rain during late senescence. In leaves of depodded soybeans, Rubisco is degraded and amino acids can be reutilized in these leaves for the synthesis of special vacuolar proteins in the paraveinal mesophyll (vegetative storage proteins). Nitrogen deriving from Rubisco degradation in older (senescing) leaves of annual crops is integrated to some extent again in newly synthesized Rubisco in younger leaves or photosynthesizing tissues of fruits. Finally, a high percentage of this nitrogen is accumulated in protein bodies (storage proteins). At the subcellular level, Rubisco can be degraded in intact chloroplasts. Reactive oxygen species may directly cleave the large subunit or modify it to become more susceptible to proteolysis. A metalloendopeptidase may play an important role in Rubisco degradation within intact chloroplasts. Additionally, the involvement of vacuolar endopeptidase(s) in Rubisco catabolism (at least under certain conditions) was postulated by various laboratories.
Bone morphogenetic proteins: An unconventional approach to isolation of first mammalian morphogens (1997)

It is conventional to identify morphogens from fly and frog embryos during morphogenesis using gene-screens, subtractive hybridizations, differential displays and expression cloning. This information is then extended to mice and men. The bone morphogenetic proteins (BMPs) are a family of pleiotropic morphogens/cytokines isolated and cloned from the demineralized extracellular matrix of adult bone. Thus, BMPs were isolated from mammalian bone by an unconventional approach. BMPs initiate the sequential developmental cascade of bone morphogenesis in ectopic sites. The pleiotropic effects of BMPs on chemotaxis, mitosis and differentiation are based on concentration-dependent thresholds. Recent work has demonstrated the critical role of BMPs in pattern formation in amphibian and chick limb development. Targeted disruption of gene function by homologous recombination has demonstrated the actions of BMPs beyond bone in such disparate tissues as kidney, eye, testis, teeth, skin and heart. The successful isolation of first mammalian morphogens has laid the foundation for the elucidation of molecular signalling during morphogenesis in bones and beyond.
Compact, low-dispersion coupling between silicagrin ® lensed fiber and nonlinear optical waveguide (2011)

We report compact graded refractive index lens which can be fusion-spliced to optical fibers by using sol-gel method. We developed optical fiber condenser which can make beam-waist diameter smaller than mode field diameter of simgle-mode fiber, and the condenser has low chromatic dispersion, difference of focal distance is only 6.5 microns between 785nm and 1550nm. We also manufactured a wavelength conversion module and SHG normalized conversion efficiency was 478%/W.
Electrochemical Continuous Decomposition of Chloroform and Other Volatile Chlorinated Hydrocarbons in Water Using a Column Type Metal Impregnated Carbon Fiber Electrode (1999)

Trihalomethane and other chlorinated hydrocarbons are known to be toxic to human health. However, removal of these compounds from water is not easy. We attempted continuous electrochemical decomposition of chloroform that is the main compound of trihalomethanes and some toxic chlorinated hydrocarbons in water using a metal-impregnated carbon fiber electrode (CFE). At Ag- and Zn-impregnated CFE, concentration of chloroform in 0.5 M K2SO4 (the supporting electrolyte) solution was decreased from 0.25 m mol/L to below the limit of detection of our analysis system (1 ppm) at a flow rate of 1 mL/min. The main product of electrolysis was methane. This high efficiency, determined by the chemical yield, hardly changed at a flow rate of 20 mL/min at a Ag-impregnated CFE. At a flow rate of 1 mL/min, chloroform was degraded with a decomposition efficiency of almost 100% even in the solution without the supporting electrolyte, whereas at a higher flow rate, the efficiency for the decomposition of chloroform decreased with a decrease in the concentration of the supporting electrolyte. Tetrachloroethylene, 1,1,1-trichloroethane, and 1,1,2-trichloroethane were also decomposed at a Ag-impregnated CFE with an efficiency of almost 100%.