gebhart/patrepeval huggingface dataset:
Radiative performance of rare earth garnet thin film selective emitters (1995)

In this paper we present the first emitter efficiency results for the thin film 40% Er‐1.5% Ho YAG (Yttrium Aluminum Garnet, Y3Al5O12) and 25% Ho YAG selective emitter at 1500 K with a platinum substrate. Spectral emittance and emissive power measurements were made (1.2<λ<3.2 μm). Emitter efficiency and power density are significantly improved with the addition of multiple rare earth dopants. Predicted efficiency results are presented for an optimized (equal power density in the Er, 4I15/2−4I13/2@ 1.5 μm, and Ho, 5I7−5I8@ 2.0 μm emission bands) Er‐Ho YAG thin film selective emitter. © 1995 American Institute of Physics.
The distribution of phosphatic facies in the Georgina, Wiso and Daly River Basins, Northern Australia (1990)

Abstract The lithological logging and chemical testing of cuttings from some 600 water bores and Bureau of Mineral Resources stratigraphic holes, together with the modelling of aeromagnetic, gravity and elevation data, have defined a carbonate-siltstone-chert phosphatic lithofacies of Middle Cambrian age. This in turn has led to the recognition of two new phosphorite deposits, the deposition of which was related to the basement configuration and its depth. The phosphatic lithofacies, which have been followed entirely in the subsurface, occur as belts peripheral to and within the Georgina, Wiso and Daly River Basins. These phosphatic belts have an average width of 32 km, a thickness of 10 to 190 m, and have been traced over a distance of 2,100 km. Of the newly discovered phosphorite deposits, the Lady Judith in the Wiso Basin rests on volcanic rocks and interdigitates with carbonates of the Montejinni Limestone, while the Ammaroo belt in the southwestern portion of the Georgina Basin is contained within a depression bounded by limestones of the Arthur Creek Formation. The phosphatic sediments are believed to have been deposited primarily as an Ordian Middle Cambrian event in the west with a ‘younging’ transition through Ordian and/or Early Templetonian to Late Templetonian in the southeast. The basins are extensional, exhibiting a series of broad downwarps crossed by peripheral aulacogens, grabens, half grabens formed in the Late Proterozoic and modified subsequently by the development of plateaux, narrow horst blocks and adjacent deeps during the Middle Cambrian along basin-dividing arches. The basement to the shallow-water phosphatic lithofacies consists of Proterozoic sediment or Early Cambrian volcanic plateaux or peripheral sloping platforms which in the Brunette Sub-basin have present elevations of 0–300 m ASL.
Control of avian mycoplasmoses by vaccination (1996)

Vaccination is an option for controlling Mycoplasma gallisepticum or M. synoviae when biosecurity measures fail to prevent the infection of poultry flocks with these mycoplasmas. Both killed vaccines (bacterins) and living vaccines are currently in commercial use. Bacterins usually contain an oil emulsion adjuvant and are administered by subcutaneous or intramuscular injection. They can reduce the decline in egg production associated with M. gallisepticum, although they do not prevent infection. Newer adjuvants, such as immune stimulating complexes, may provide effective immunity without the tissue lesions caused by oil emulsion adjuvants. Living M. gallisepticum vaccines include the F strain and attenuated strains ts-11 and 6/85. F strain is administered in drinking water or by aerosol. This strain reduces the decline in egg production and has been used to displace endemic strains in multiple-age flocks. The major disadvantage is the inherent virulence of F strain. Strain ts-11 is less virulent and less infectious than F strain and provides a somewhat weaker, but usually effective, long-term protective immunity, which is vaccine-dose dependent. This strain is administered by eye drop, persists in the chicken for long periods and stimulates a detectable although variable systemic antibody response. Strain ts-11 can be used safely in combination with respiratory virus vaccines. Strain 6/85 also stimulates a weaker protective immune response than F strain and is of low virulence and infectivity. This strain is administered by aerosol, appears not to persist in vaccinated birds and may fail to stimulate a detectable systemic antibody response. Strain MS-H is currently being evaluated as a live vaccine against M. synoviae in meat chicken breeder flocks and is often used in conjunction with strain ts-11.
Population Pharmacokinetic Modeling After Repeated Administrations of RBP-6000, a New, Subcutaneously Injectable, Long-Acting, Sustained-Release Formulation of Buprenorphine, for the Treatment of Opioid Use Disorder (2015)

RBP-6000 is a novel sustained-release formulation of buprenorphine for the treatment of opioid use disorder, which has been designed for once-monthly (28 days) subcutaneous (SC) injections. A population pharmacokinetic (PK) model was developed to describe the time course of buprenorphine plasma concentrations after repeated SC injections of RBP-6000 at 50 mg, 100 mg, 200 mg, or 300 mg in treatment-seeking opioid-dependent subjects previously on sublingual buprenorphine (Subutex(®) ) treatment. The μ-opioid receptor occupancy was predicted using a previously developed PK/PD Emax model. The results of the population PK analysis jointly with the predicted level of μ-opioid receptor occupancy provided quantitative criteria for clinical dose selection for RBP-6000: the dose of 300 mg every 28 days seems appropriate for immediately achieving an effective exposure after the first SC injection and to maintain effective levels of exposure during chronic treatment. Furthermore, simulations conducted to evaluate the potential impact of a holiday in drug intake indicated that in the unexpected event of a 2-week holiday, levels of μ-opioid receptor occupancy remained consistently above 70% with no significant loss of drug efficacy. This analysis indicated that RBP-6000 has the potential for becoming an effective treatment for opioid-dependent subjects by addressing compliance issues associated with the current once-a-day treatments.
pMSE Mechanism: Differentially Private Synthetic Data with Maximal Distributional Similarity (2018)

We propose a method for the release of differentially private synthetic datasets. In many contexts, data contain sensitive values which cannot be released in their original form in order to protect individuals' privacy. Synthetic data is a protection method that releases alternative values in place of the original ones, and differential privacy (DP) is a formal guarantee for quantifying the privacy loss. We propose a method that maximizes the distributional similarity of the synthetic data relative to the original data using a measure known as the pMSE, while guaranteeing epsilon-differential privacy. Additionally, we relax common DP assumptions concerning the distribution and boundedness of the original data. We prove theoretical results for the privacy guarantee and provide simulations for the empirical failure rate of the theoretical results under typical computational limitations. We also give simulations for the accuracy of linear regression coefficients generated from the synthetic data compared with the accuracy of non-differentially private synthetic data and other differentially private methods. Additionally, our theoretical results extend a prior result for the sensitivity of the Gini Index to include continuous predictors.
Dielectric Charging of RF MEMS Capacitive Switches under Bipolar Control-Voltage Waveforms (2007)

Bipolar control-voltage waveforms have been proposed to mitigate dielectric charging in RF MEMS capacitive switches. In this work, for the first time, dielectric charging under bipolar waveforms is modeled and characterized quantitatively. In general, the experimental results agree with predictions based on the superposition of charging models that are extracted under either positive or negative voltage only. The present analysis indicates that, while bipolar waveforms can reduce charging, it is difficult to fine tune the waveforms to completely eliminate charging.
Profibrillin‐1 maturation by human dermal fibroblasts: Proteolytic processing and molecular chaperones (2003)

Fibrillin-1 is synthesized as a proprotein that undergoes proteolytic processing in the unique C-terminal domain by a member of the PACE/furin family of endoproteases. This family of endoproteases is active in the trans-Golgi network (TGN), but metabolic labeling studies have been controversial as to whether profibrillin-1 is processed intracellularly or after secretion. This report provides evidence that profibrillin-1 processing is not an intracellular event. Bafilomycin A(1) and incubation of dermal fibroblasts at 22 degrees C were used to block secretion in the TGN to confirm that profibrillin-1 processing did not occur in this compartment. Profibrillin-1 immunoprecipitation studies revealed that two endoplasmic reticulum-resident molecular chaperones, BiP and GRP94, interacted with profibrillin-1. To determine the proprotein convertase responsible for processing profibrillin-1, a specific inhibitor of furin, alpha-1-antitrypsin, Portland variant, was both expressed in the cells and added to cells exogenously. In both cases, the inhibitor blocked the processing of profibrillin-1, providing evidence that furin is the enzyme responsible for profibrillin-1 processing. These studies delineate the secretion and proteolytic processing of profibrillin-1, and identify the proteins that interact with profibrillin-1 in the secretory pathway.
Face Recognition in Unrestricted Posture using Invariant Image Information (2004)

In face recognition (face verification, face expression etc.), a full face or near full face is used and the face image is about fixed size in general. Especially, eyes, nose and mouth are usually located from the upper part to the lower part in the input image. But, in order to recognize the face in any posture, it is important to remove an influence caused by the position and three-dimensional turning of the face. The authors propose a method for detecting the face position in unknown posture, using an invariant image information. First, we show that the spectrum, which is obtained by polar transform and Fourier transform of the image, is shift-invariant and rotation-invariant, and is shift-invariant toward depth. Next, we describe on the detection of the face position in unrestricted posture, using the calculation of correlation of the spectrum. In this paper, the proposal method is explained and the experimental result, which is performed to verify the efficacy of the method, is demonstrated.
DIGITAL FILTER DESIGN TECHNIQUES (1965)

Abstract : Digital filtering is the process of spectrum shaping using digital components as the basic elements. Increasing speed and decreasing size and cost of digital components make it likely that digital filtering, already used extensively in the computer simulation of analog filters, will perform, in real- time devices, the functions which are now performed almost exclusively by analog components. In this paper, using the z-transform calculus, several digital filter design techniques are reviewed, and new ones are presented. One technique can be used to design a digital filter whose impulse response is like that of a given analog filter; another technique is suitable for the design of a digital filter meeting frequency response criteria. A third technique yields digital filters with linear phase, specified frequency response, and controlled impulse response duration. The effect of digital arithmetic on the behavior of digital filters is also considered.
Contact Stress and Deformation of Blade Bearing in Wind Turbine (2010)

Slewing ring with negative clearance is used as blade bearing in wind turbine. Negative clearance dramatically increase contact forces between balls and raceways. Existing methods for calculating loads between raceway and balls in four contact-point slewing ring suppose that the raceways are rigid and only assume elastic deformations of rolling elements. Experiments show that negative clearance dramatically increase contact forces between balls and raceways, and these forces make elastic deformations in rings of blade bearing. This paper investigates the relation between negative clearance and contact stress. A computation model for blade bearing without external load but considering elasticity of rings in computation is established and solve methods are discussed.
Identification of Three Immunologic Correlates for HIV Type 1 Pathogenesis in Youth (2010)

To evaluate the stability and heterogeneity of cytokine and chemokine profiles in 80 youth with and without HIV-1 infection, we tested plasma samples at repeated visits without antiretroviral therapy. Among nine analytes that were quantified using multiplexing assays, interleukin 10 (IL-10), IL-18, and soluble CD30 persistently showed a positive correlation with HIV-1 viral load (Spearman ρ = 0.40-0.59, p < 0.01 for all). A negative correlation with CD4(+) T cell counts (ρ = -0.40 to -0.60, p < 0.01 for all) was also persistent for the three analytes. Analyses restricted to 48 AIDS-free youth (96 visits) yielded similar findings, as did multivariable models in which race, sex, age, body mass index, and time interval between visits were treated as covariates. These relationships reflected two novel features observed for all three analytes. First, their presence in plasma was relatively stable between visits (ρ = 0.50-0.90, p < 0.03), regardless of HIV-1 infection status. Second, pairwise correlation was strong and persistent in HIV-1-seropositive youth (ρ = 0.40-0.59, p < 0.01), but not in HIV-1, seronegatives (p > 0.13). Additional analytes, especially eotaxin/CCL11 and SDF-1β/CXCL12, had no correlation with HIV-1-related outcomes despite their stability between visits. Overall, circulating IL-10, IL-18, and soluble CD30 could partially track unfavorable responses to HIV-1 infection in youth. These markers of persistent immune activation are individually and collectively indicative of HIV-1 pathogenesis.
Multi-Stage Beamforming for Coded OFDM with Multiple Transmit and Multiple Receive Antennas (2007)

Conventionally, subcarrier based beamforming was used in an OFDM (orthogonal frequency division multiplexing) system under MIMO (multiple-input and multiple-output) channels to achieve optimal performance, where many DFT/IDFT (discrete Fourier transform/inverse DFT) blocks, each corresponding to one antenna, are required. To reduce the complexity induced by the DFT/IDFT processing, symbol based beamforming was recently proposed with only one IDFT block at the transmitter and one DFT block at the receiver. However, this approach results in a significant performance loss especially when the number of distinct paths in the channel is large. In this paper, we propose a multi-stage beamforming (MSB) scheme for MIMO-OFDM systems employing both the principles of subcarrier level beamforming and symbol level beamforming to effectively tradeoff system performance and complexity. Using the proposed MSB scheme and with a little complexity increase compared with the symbol based beamforming, system performance can be significantly improved. Under some channel conditions, the proposed MSB scheme can achieve a performance close to the optimal subcarrier based beamforming scheme but with much lower complexity. For the MSB scheme, we propose an iterative algorithm to jointly optimize the symbol level and subcarrier level weighting coefficients. To reduce the complexity of the joint weighting coefficients calculation algorithm, we propose a reduced complexity algorithm to first obtain the symbol level weighting coefficients and then the subcarrier level weighting coefficients. Simulation results show that good performance can be achieved using the proposed weighting coefficients calculation algorithms with reasonable complexity
The wound healing, chronic fibrosis, and cancer progression triad (2014)

For decades tumors have been recognized as "wounds that do not heal." Besides the commonalities that tumors and wounded tissues share, the process of wound healing also portrays similar characteristics with chronic fibrosis. In this review, we suggest a tight interrelationship, which is governed as a concurrence of cellular and microenvironmental reactivity among wound healing, chronic fibrosis, and cancer development/progression (i.e., the WHFC triad). It is clear that the same cell types, as well as soluble and matrix elements that drive wound healing (including regeneration) via distinct signaling pathways, also fuel chronic fibrosis and tumor progression. Hence, here we review the relationship between fibrosis and cancer through the lens of wound healing.
PET Imaging of Liposomal Glucocorticoids using <sup>89</sup>Zr-oxine: Theranostic Applications in Inflammatory Arthritis (2020)

The encapsulation of Glucocorticoids (GCs) into long-circulating liposomes (LCLs) is a proven strategy to reduce the side effects of glucocorticoids and improve the treatment of inflammatory diseases, such as rheumatoid arthritis (RA). With the aim of supporting the development of GC-loaded LCLs, and potentially predict patient response to therapy clinically, we evaluated a direct PET imaging radiolabelling approach for preformed GC-LCLs in an animal model of human inflammatory arthritis. <b>Methods:</b> A preformed PEGylated liposomal methylprednisolone hemisuccinate (NSSL-MPS) nanomedicine was radiolabelled using [<sup>89</sup>Zr]Zr(oxinate)<sub>4</sub> (<sup>89</sup>Zr-oxine), characterised and tracked <i>in vivo</i> using PET imaging in a K/BxN serum-transfer arthritis (STA) mouse model of inflammatory arthritis and non-inflamed controls. Histology and joint size measurements were used to confirm inflammation. The biodistribution of <sup>89</sup>Zr-NSSL-MPS was compared to that of free <sup>89</sup>Zr in the same model. A therapeutic study using NSSL-MPS using the same time points as the PET/CT imaging was carried out. <b>Results:</b> The radiolabelling efficiency of NSSL-MPS with [<sup>89</sup>Zr]Zr(oxinate)<sub>4</sub> was 69 ± 8 %. PET/CT imaging of <sup>89</sup>Zr-NSSL-MPS showed high uptake (3.6 ± 1.5 % ID; 17.4 ± 9.3 % ID/mL) at inflamed joints, with low activity present in non-inflamed joints (0.5 ± 0.1 % ID; 2.7 ± 1.1 % ID/mL). Importantly, a clear correlation between joint swelling and high <sup>89</sup>Zr-NSSL-MPS uptake was observed, which was not observed with free <sup>89</sup>Zr. STA mice receiving a therapeutic dose of NSSL-MPS showed a reduction in inflammation at the time points used for the PET/CT imaging compared with the control group. <b>Conclusions:</b> PET imaging was used for the first time to track a liposomal glucocorticoid, showing high uptake at visible and occult inflamed sites and a good correlation with the degree of inflammation. A subsequent therapeutic response matching imaging time points in the same model demonstrated the potential of this radiolabeling method as a theranostic tool for the prediction of therapeutic response - with NSSL-MPS and similar nanomedicines - in the treatment of inflammatory diseases.
Real-Time PCR Assay for Quantitative Mismatch Detection (2003)

We describe here a quantitative real-time PCR assay for the detection of single-base-pair differences that does not require fluorescently labeled gene-specific probes or complicated primer combinations. Following PCR or RT-PCR of a gene segment that may contain allele-specific differences, 100 pg amplified product are used for a real-time PCR with allele-specific primers and SYBR Green. The use of HEPES buffer at a pH of 6.95 together with AmpliTaq DNA polymerase results in a threshold difference between the correct template and the mismatched template of as many as 20 cycles, depending on the mismatch. Correct matches can be detected in an excess of mismatched template at least at the 0.01 level for the six primer-template matches versus mismatches tested: GC vs. A.C, AT vs. G.T, GC vs. C.C, GC vs. G.G, AT vs. C.T, and GC vs. G.A. Because the initial amplification is separate from real-time detection, conditions can be independently optimized for each step, making the assay particularly suitable for the detection of allele-specific expression in single cells.
Feasibility, Motivation, and Selective Motor Control: Virtual Reality Compared to Conventional Home Exercise in Children with Cerebral Palsy (2006)

Children with cerebral palsy (CP) have difficulty controlling and coordinating voluntary muscle, which results in poor selective control of muscle activity. Children with spastic CP completed ankle selective motor control exercises using a virtual reality (VR) exercise system and conventional (Conv) exercises. Ankle movements were recorded with an electrogoniometer. Children and their parents were asked to comment on their interest in the exercise programs. Greater fun and enjoyment were expressed during the VR exercises. Children completed more repetitions of the Conv exercises, but the range of motion and hold time in the stretched position were greater during VR exercises. These data suggest that using VR to elicit or guide exercise may improve exercise compliance and enhance exercise effectiveness.
Amino acid residues 1101-1105 of the isotypic region of human C4B is important to the covalent binding activity of complement component C4 (1991)

The C4A and C4B isotypes of human C4 show certain functional differences that stem from their relative preference for transacylation to amino (-NH2) vs hydroxyl (-OH) nucleophiles, respectively, on complement-activating surfaces. Comparison of amino acid sequences of the alpha-chain fragment of C4, C4d, has shown C4A- and C4B-specific sequences at residues 1101-1106 are the only consistent structural difference between isotype, i.e., Pro, Cys, Pro, Val, Leu, Asp in C4A and Leu, Ser, Pro, Val Ile, His in C4B. These residues may be responsible either in part or entirely for properties associated with isotype. To examine the functional role of residues 1101-1106 in C4B-mediated hemolysis, whole serum or immunopurified human C4 with allotypes, A3B1, A3, B2B1, or B1 were preincubated in the presence or absence of an antipeptide mAb (BII-1) specific for amino acid residues 1101-1105 of C4B. Sensitized sheep E and C4-deficient guinea pig serum was then added and lysis measured by absorbance at 415 nm. Our results show lysis of antibody-sensitized sheep E is inhibited by antibody and C4B2B1, C4B1, or C4A3B1 but not antibody and C4A3. The interference of hemolysis by BII-1 could not be explained by inhibition of activation of C4B or inhibition of C3 or C5 convertase activity. Furthermore, results from uptake experiments show that BII-1 interferes with the covalent binding activity of C4B, indicating residues 1101-1105 play a role in the covalent binding reaction of C4B to the target E-antibody complex.