gebhart/patrepeval huggingface dataset:
Development of a HOM-damped cavity for the KEK B-factory (KEKB) (2002)

This paper describes a high-power test model of the normal conducting RF cavity for the KEK B Factory, KEKB. This cavity is loaded with a large coaxial waveguide for higher order mode (HOM) damping. The waveguide is equipped with a notch filter designed to block the TEM wave at the accelerating frequency of 509 MHz. Other waves coupled with the cavity HOMs are guided through the filter and absorbed by bullet-shape sintered SiC ceramics. This prototype model has been designed and built to demonstrate the performance in high power operation and the fabrication technologies involved. The results of the high-power test is reported together with the cavity structure and its RF properties.
3-Cyano-4,6-disubstituted-2(1<i>H</i>)-imino or oxopyridines: New Antineoplastic Agents with High Selectivity Towards Leukemia Cell Lines (1998)

Two series of 3-cyano-2(1H)-oxopyridine and 3-cyano-2(1H)-iminopyridine derivatives carrying various aryl substituents at position 4 and (4-((7-chloro or trifluoromethylquinol-4-yl)amino)phenyl) substituent at position 6 were synthesized and evaluated for their antitumor activity. Compounds 3f and 6d showed high selectivity towards leukemia cell lines with full panel median growth inhibition GI50 average sensitivity towards all cell lines (MG-MID) at 7.9 and 19.7 μM and leukemia subpanel GI50 average sensitivity towards leukemia cell lines (MG-MID) at 1.74 and 2.9 μM, respectively, also they exhibited full panel total growth inhibition TGI (MG-MID) at 34.8 and 59.0 μM and leukemia subpanel TGI (MG-MID) at 5.3 and 13.5 μM, respectively.
Differential Effects of Immunisation with Mycobacterial 65 kD Heat Shock Protein on Two Models of Autoimmunity (1993)

The effects of preimmunisation with the 65 kD mycobacterial heat shock protein (hsp65) on 2 murine models of autoimmunity were compared. Experimental autoimmune haemolytic anaemia (AIHA) can be provoked in mice by repeated injection with rat red blood cells (RBC). In this model, preimmunisation with hsp65 10 days before induction of disease resulted in a partial, but significant, reduction in RBC-bound autoantibody levels measured by Coombs' test. However, preimmunisation with human IgG (hIgG) was associated with a similar suppressive effect. Administration of neither hsp65 nor hIgG affected the direct or indirect anti-rat agglutinin titres of mice subsequently injected with rat RBC. Injection of hsp65 or hIgG prior to induction of AIHA elicited the production of IgG antibodies against the respective immunogen, as judged by enzyme-linked immunosorbent assays. In contrast to the results in experimental AIHA, pristane-induced arthritis (PIA) was effectively prevented by preimmunisation with hsp65, but not with hIgG. It is considered that, whilst hsp65 injection may slightly reduce subsequent anti-RBC autoantibody production in AIHA by antigenic competition, such a mechanism cannot account for the substantial protection against PIA afforded by hsp65 preimmunisation. We suggest that the high, sustained production of anti-hsp65 antibodies observed in mice given hsp65 and pristane may play a role in specifically suppressing arthritogenic immune responses in PIA.
Glutathione reductase from Escherichia coli: cloning and sequence analysis of the gene and relationship to other flavoprotein disulfide oxidoreductases (1986)

A glutathione reductase negative strain of Escherichia coli K-12 was isolated as a thermoresistant survivor when a gor::MuctsAp lysogen was subjected to elevated temperature. It was found that in addition to being ampicillin sensitive this mutant was hypersensitive to arsenate, which may be connected with the fact that the gor gene maps between 77 and 78 min on the E. coli genome, close to the pit locus encoding the major arsenate transport system of E. coli. A derivative of this mutant was used as the recipient in a screen of the Clarke and Carbon hybrid plasmid bank of E. coli DNA. A plasmid, pGR, was isolated that encodes both an arsenate-resistance element and glutathione reductase. Restriction mapping of this plasmid showed that the insert DNA is approximately 10 kilobase pairs in length, and a fragment of the gor gene was identified that allowed the gor gene to be accurately mapped on pGR by a combination of restriction analysis and Southern blotting. The DNA sequence of the gor gene was determined and found to encode a protein of 450 amino acid residues. The glutathione reductase of E. coli is very homologous to the human enzyme and is also related (though less closely) to other flavoprotein disulfide oxidoreductases whose sequences are available. These enzymes have retained a common mechanism while evolving different specificities.
Compiler-Directed Dynamic Frequency and Voltage Scheduling (2000)

Dynamic voltage and frequency scaling has been identified as one of the most effective ways to reduce power dissipation. This paper discusses a compilation strategy that identifies opportunities for dynamic voltage and frequency scaling of the CPU without significant increase in overall program execution time. The paper introduces a simple, yet effective performance model to determine an efficient CPU slow-down factor for memory bound loop computations. Simulation results of a superscalar target architecture and a program kernel compiled at different optimizations levels show the potential benefit of the proposed compiler optimization. The energy savings are reported for a hypothetical target machine with power dissipation characteristics similar to Transmeta’s Crusoe TM5400 processor.
The Influence of Age and Electrical Nerve Stimulation on Motor Function (2018)

This dissertation comprises five experimental studies that investigated changes in manual dexterity across the lifespan and the effects of electrical nerve stimulation on motor function and muscle activity. Three studies evaluated associations between neuromuscular characteristics and performance on the NIH Toolbox measures of manual dexterity, and two studied the effects of electrical nerve stimulation on changes in motor function and muscle activity.\nThe first two studies measured neuromuscular differences in middle-aged and older adults, and used performance metrics to identify age-specific associations with manual dexterity. The first study provided a tractable framework to identify latent variables underlying age-associated differences in time to complete the 9-hole and grooved pegboard tests. Mechanisms of interest included neuromuscular characteristics, cognitive function, and cutaneous sensation. The second study expanded these measures to include assessments of risk behavior and muscle activation characteristics. Significant associations were unique for each age group and pegboard test with features derived from force-matching tasks and utility of the reward providing the greatest explanatory power.\nThe third study assessed grooved pegboard timing and force characteristics of peg manipulation for persons with multiple sclerosis and age-and sex-matched healthy adults. Results from this study showed that grooved pegboard time for individuals with multiple sclerosis was most associated with the time to select a peg, whereas times for healthy controls were most related to peg transportation and selection.\nThe last two studies examined the effects of electrical nerve stimulation on force production, muscle activation characteristics, and functional outcomes. The fourth study showed that the immediate effects of electrical nerve stimulation on force and motor unit activity of the contralateral limb were present after stimulation. Lastly, an intervention of electrical nerve stimulation applied to the calf muscled improved mobility, where motor unit discharge characteristics during steady contractions partially explained differences in mobility among older adults.\nThis dissertation explored the changes in motor function and muscle activity with advancing age and the modulation of motor function with electrical nerve stimulation.
Thermodynamic Modeling for Organic Solid Precipitation (1992)

Abstract A generalized predictive model which is based on thermodynamic principle for solid-liquid phase equilibrium has been developed for organic solid precipitation. The model takes into account the effects of temperature, composition, and activity coefficient on the solubility of wax and asphaltenes in organic solutions. The solid-liquid equilibrium K-value is expressed as a function of the heat of melting, melting point temperature, solubility parameter, and the molar volume of each component in the solution. All these parameters have been correlated with molecular weight. Thus the model can be applied to crude oil systems. The model has been tested with experimental data for wax formation and asphaltene precipitation. The predicted wax appearance temperature is very close to the measured temperature. The model not only can match the measured asphaltene solubility data but also can be used to predict the solubility of asphaltene in organic solvents or crude oils. The model assumes that asphaltenes are dissolved in oil in a true liquid state, not in colloidal suspension, and precipitation-dissolution process is reversible by changing thermodynamic conditions. The model is thermodynamically consistent and has no ambiguous assumptions.
Investigations on the Toxicity of Bile Salt Solutions, Capmul 8210 and a Bile Salt-EDTA Solution for Common Bile Duct Perfusion in Dogs (1984)

The following perfusion media for dissolving bile duct calculi were infused via a cutaneobiliary tube into the biliary tract of 12 mongrel dogs: 4.3% cholate solution, 0.34% chenodeoxycholate solution, Capmul, GMOC (special formulation of Capmul), BA-EDTA and 0.9% saline. Infusion lasted 50 h. Postmortem examination revealed hemorrhagic, partly phlegmonous cholangitis, acute duodenitis, necrosis and abscesses in the liver. The lesions were most pronounced after the cholate solution and with Capmul and GMOC, but were only detected to a slight extent after BA-EDTA and the chenodeoxycholate solution. 0.9% saline had no side effects. The investigations could demonstrate that it is the very irrigation media that today are recommended for treatment of bile duct stones in patients, that cause considerable morphologic side effects. The alternating administration of an EDTA solution with a Capmul preparation may diminish local toxicity of the latter.
Analysis of Medium Access Protocols for Power Line Communication Realizing In-Car Networks (2014)

The number of electronic control units in today's vehicles is permanently increasing. The complexity of the in-car communication also increases because of the growing demand for information exchange. In the past decades rising demands have been countered with adding bus-segments. In order to reduce the complexity and the costs for the future in-car communication infrastructure, power line communication (PLC) provides an alternative. In this paper, we focus on PLC which can reduce the cabling to a minimum. After summarizing the requirements for future in-car systems, the HomePlug Green PHY standard, originally designed for Smart Grid applications, is analyzed according to its applicability to the in-car communication. Due to the availability of standard components, also cost reasons motivate the use of the HomePlug Green PHY standard. To cope with the small message size of in-car communication, we propose a concept for data transfer inside the Frame Control to reduce protocol overhead. In addition to CSMA/CA based medium access, we evaluate and compare two further collision-free variants requiring only slight protocol modifications. As one evaluation result, a priority-based access scheme shows the most promising results.
Multidisciplinary and Historical Perspectives for Developing Intelligent and Resource-Efficient Systems (2018)

As communication and computation systems become more complex and target at higher performance, the fundamental limits of nature can be expected to constrain their development and optimization. This calls for intelligent use of basic resources, that is, materials, energy, information, time, frequency, and space. We present a multidisciplinary and historical review on the body of knowledge that can be applied in researching, such as intelligent and resource-efficient systems. We review general system theory, decision theory, control theory, computer science, and communication theory. While multidisciplinarity has been recognized as important, there are no earlier reviews covering all these five disciplines. Based on the review, we build a chronology of intelligent systems and identify connections between the disciplines. Optimization, decision-making, open- and closed-loop control, hierarchy, and degree of centralization turn out to be recurring themes in these disciplines, which have converged to similar solutions that are based on remote control, automation, autonomy, and self-organization. We use future wireless networks as an example to illustrate the open questions and how they can be addressed by applying multidisciplinary knowledge. This paper can help researchers to use knowledge outside their own field and avoid repeating the work done already. The resulting consolidated view can speed up research and is especially important when the fundamental limits of nature are approached and new insights are required to overcome the challenges. The general, long-standing problem to be tackled is multiobjective optimization with autonomous and distributed decision-making in an uncertain, dynamic, and nonlinear environment where the objectives are mutually conflicting.
The Nation's Health Information Network: History of the Regional Medical Library Program, 1965-1985. (1987)

Les avancees technologiques laissent entrevoir l'eclatement des bibliotheques: d'un cote, institution sociale pour les besoins culturels de la population, tres proche de nos actuelles bibliotheques; de l'autre ensemble de services d'information delocalises pour des utilisateurs specialises utilisant les technologies de pointe
Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis (2015)

This third edition of the biomedical optics classic Tissue Optics covers the continued intensive growth in tissue optics-in particular, the field of tissue diagnostics and imaging-that has occurred since 2007. As in the first two editions, Part I describes fundamentals and basic research, and Part II presents instrumentation and medical applications. However, for the reader's convenience, this third edition has been reorganized into 14 chapters instead of 9. The chapters covering optical coherence tomography, digital holography and interferometry, controlling optical properties of tissues, nonlinear spectroscopy, and imaging have all been substantially updated. The book is intended for researchers, teachers, and graduate and undergraduate students specializing in the physics of living systems, biomedical optics and biophotonics, laser biophysics, and applications of lasers in biomedicine. It can also be used as a textbook for courses in medical physics, medical engineering, and medical biology.
Occurrence of DNA Sequences Specifically Recognized by Drugs in Human Promoters (2002)

Several DNA-binding drugs are being developed to create tailored molecules which can discriminate among the different sequences of the whole genome. By discriminating among specific sites in DNA, these molecules may provide optimal drug therapy. The complete sequencing of the human genome offers a wealth of DNA targets to be analyzed as potential drug-binding sites. To increase our understanding of DNA-drug interactions and their selectivity, we have studied the relative and absolute occurrence of CG-rich sequences, of various lengths, in human gene promoters. In several promoters, including those of oncogenes, cell cycle regulation factors, tumor suppressors and housekeeping genes, the presence of potential binding sites containing CpG steps (in which many drugs are known to intercalate) is variable, but in many cases these sites are not randomly distributed. Sequences 6-7 base pairs in length, like CGCCCG or CGCCCCG, occur only once in some promoters, thus they may be potentially specific therapeutic targets.
[Sequencing of hepatitis B virus DNA fragment coding major HBsAg of escape mutant]. (1994)

We amplificated a HBV DNA fragment coding the major HBsAg from a chronic HBsAg carrier's serum with high titer of HBsAg and anti-HBs using polymerase chain reaction (PCR). The direct sequencing of PCR products revealed a single mutation from adnosine to guanosine at the nucleotide position 532 of HBV DNA of the escape mutant. This mutation might result in an amino acid substitution from threonine to alanime at the amino acid position 126 of HBsAg. Since this amino acid is located in the first loop of the "a" determinant of HBsAg, the mutation might result in an alteration of the structural antigenicity of the "a" determinant and induce escape mutant of HBV.
FB-Diff: A Feature Based Difference Detection Algorithm for Process Models (2017)

Detecting difference between process models is important for many business process management scenarios, such as process version control and process merging. However, it is far from trivial to detect the process difference. Existing work suffers from drawbacks like inappropriate data structure support or expensive computation. In this paper, we propose FB-Diff, a feature-based difference detection approach. Firstly, a semi-ordered tree model called task based process structure tree (TPST) is used to represent a process model, which can correctly describe the structure as well as the behavior (the execution sequence of task nodes). Then FB-Diff adopts a divide and conquer strategy to find the similar parts of two TPSTs. Specifically, we divide the TPST into fragments that are represented by feature vectors. A feature vector consists of six features, and each feature describes a key characteristic of the fragment. Based on the similar parts, the edit script that can transform one TPST into the other is generated. The extensive experimental evaluation shows that our method can meet the real requirements in terms of precision and efficiency.
A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection (2017)

Interleukin-22 (IL-22) plays an important role in host immunity and tissue homeostasis in infectious and inflammatory diseases. However, the function and regulation of IL-22 in viral infection remain largely unknown. Here, we report that viral infection triggered early IL-22 production from the liver and lymphoid organs. γδ T cells are the main immune cells to produce IL-22 in the liver, a process mediated by the IL-23/phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway. In the presence of IL-23, IL-22 production is independent of aryl hydrocarbon receptor (AhR) signaling. In acute and persistent viral infections, IL-22 deficiency resulted in thymic and splenic hypertrophy, while excessive IL-22 induced atrophy in these lymphoid organs. Moreover, IL-22 deficiency enhanced T cell responses to promote viral clearance, but increased IL-22 in vivo decreased T cell numbers and functions in the liver and lymphoid tissues. Together, our findings reveal a significant effect of the IL-23/PI3K/mTORC1 axis on regulating IL-22 production and also identify a novel role of IL-22 in controlling antiviral T cell responses in the non-lymphoid and lymphoid organs during acute and persistent viral infections.
Norfloxacin and silver norfloxacin in the treatment of Pseudomonas corneal ulcer in the rabbit. (1984)

Norfloxacin is a new synthetic antibiotic with a broad spectrum of activity against gram-positive and gram-negative bacteria, and is more effective than the aminoglycosides against P aeruginosa. In this study norfloxacin was particularly effective in treatment of P aeruginosa infection of the rabbit cornea, and caused no toxicity in normal rabbit eyes after prolonged administration. The addition of silver to norfloxacin enhances its antipseudomonal activity, and broadens its spectrum to include antifungal activity. In this study, silver norfloxacin appears to be the most effective antibiotic against P aeruginosa corneal ulcer in the rabbit. Because of its broad antibacterial spectrum, silver norfloxacin may be useful in the initial treatment of bacterial corneal ulcer before the identity of the bacteria is known. Because of its low toxicity in topical administration, and its antifungal and antibacterial activity, silver norfloxacin may be helpful in prophylaxis against infection in chronic corneal ulcers.
A beacon navigation method for autonomous vehicles (1989)

A method for navigating autonomous vehicles is presented. Based on the three-point problem from land surveying, this navigational technique makes use of angular measurements between fixed beacon pairs. Extremely accurate position information can be obtained over a large area with simple trigonometric or analytic geometry calculations. Typical worst-case errors are of the order of 10 cm throughout a 2500 m/sup 2/ workspace. An experimental position-measuring system has been built and tested, and it demonstrated the ability of this technique to function as a key element in a navigation system for autonomous vehicles.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Thyrotropin releasing hormone stimulates transient phosphorylation of the tissue-specific transcription factor, Pit-1. (1994)

The hypothalamic hormone, thyrotropin releasing hormone (TRH), stimulates prolactin (PRL) secretion and gene transcription in the GH3 pituitary cell line. Several studies have provided indirect evidence that phosphorylation of the pituitary-specific transcription factor Pit-1 may mediate TRH effects on PRL transcription. In the present study we have investigated the ability of TRH to alter the phosphorylation of Pit-1. In vivo 32P labeling experiments demonstrated that TRH stimulated a transient phosphorylation of Pit-1, reaching a maximum in 5 min and returning to basal levels within 30 min. Phosphopeptide mapping experiments demonstrated that TRH induced the transient phosphorylation of specific sites in Pit-1. TRH-stimulated phosphorylation of Pit-1 was blocked by treatments that deplete the cellular content of protein kinase C. Metabolic labeling and Western blot analysis demonstrate that TRH does not alter the total cellular content or nuclear concentration of Pit-1. TRH-mediated stimulation of a PRL promoter-luciferase fusion gene occurred under conditions that blocked the transient phosphorylation of Pit-1. These studies suggest that phosphorylation of Pit-1 may not be necessary for TRH mediated enhancement of PRL gene transcription.