gebhart/patrepeval huggingface dataset:
Development of Hematopoietic Stem and Progenitor Cells From Human Pluripotent Stem Cells (2015)

Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), provide a new cell source for regenerative medicine, disease modeling, drug discovery, and preclinical toxicity screening. Understanding of the onset and the sequential process of hematopoietic cells from differentiated hPSCs will enable the achievement of personalized medicine and provide an in vitro platform for studying of human hematopoietic development and disease. During embryogenesis, hemogenic endothelial cells, a specified subset of endothelial cells in embryonic endothelium, are the primary source of multipotent hematopoietic stem cells. In this review, we discuss current status in the generation of multipotent hematopoietic stem and progenitor cells from hPSCs via hemogenic endothelial cells. We also review the achievements in direct reprogramming from non-hematopoietic cells to hematopoietic stem and progenitor cells. Further characterization of hematopoietic differentiation in hPSCs will improve our understanding of blood development and expedite the development of hPSC-derived blood products for therapeutic purpose.
Managers in Senegal Facing the Challenges of Ethics and CSR (2018)

CSR has always fed on the mainstream of Business Ethics, which invites organizations to take on moral responsibilities towards society.Indeed, ethics has become a new structuring paradigm in the current context of defiance of modern firms.This article attempts to provide some necessary answers to the clarification of the concept in the dynamics of CSR.It seeks to model the managerial ethical posture of the leaders in Senegal.The modeling methods by the structural equations specifically the PLS will be mobilized.
Nanocrystal quantum dots, second edition (2010)

Soft Chemical Synthesis and Manipulation of Semiconductor Nanocrystals, J.A. Hollingsworth and V.I. Klimov Electronic Structure in Semiconductor Nanocrystals: Optical Experiment, D.J. Norris Fine Structure and Polarization Properties of Band-Edge Excitons in Semiconductor Nanocrystals, A.L. Efros Intraband Spectroscopy and Dynamics of Colloidal Semiconductor Quantum Dots, P. Guyot-Sionnest, M. Shim, and C. Wang Multiexciton Phenomena in Semiconductor Nanocrystals, V.I. Klimov Optical Dynamics in Single Semiconductor Quantum Dots, K.T. Shimizu and M.G. Bawendi Electrical Properties of Semiconductor Nanocrystals, N.C. Greenham Optical and Tunneling Spectroscopy of Semiconductor Nanocrystal Quantum Dots, U. Banin and O. Millo Quantum Dots and Quantum Dot Arrays: Synthesis, Optical Properties, Photogenerated Carrier Dynamics, Multiple Exciton Generation, and Applications to Solar Photon Conversion, A. J. Nozik and O.I. Micic Potential and Limitations of Luminescent Quantum Dots in Biology, H. Mattoussi Colloidal Transition-Metal-Doped Quantum Dots, R. Beaulac, S.T. Ochsenbein, and D.R. Gamelin Index
Extracellular Vesicle Profiling and Their Use as Potential Disease Specific Biomarker (2014)

Cell-derived vesicles in particular extracellular vesicles (EVs) such as microparticles (MPs) and microvesicles besides exosomes are raising more and more attention as a novel and unique approach to detect diseases. It has recently become apparent that disease specific MP signatures or profiles might be beneficial to differentiate chronic liver diseases such as non-alcoholic fatty liver disease and chronic hepatitis C, to monitor their progression or possibly to assess treatment outcome. Therefore EVs might serve as a novel inexpensive and minimally invasive method to screen risk patients for the outbreak of a disease even before the initial symptoms, to follow up treatment complications and disease relapse. The purpose of the current review is to summarize already published EVs signatures for a limited number of exemplary diseases and to discuss their possible impact. Additionally, it will be discussed if the combination of EV profiling and miRNA profiling could be a future joint tool for the purpose of detecting cancer and from far larger interest to ultimately distinguish among various tumor entities. EVs might increase the chance of early detection of chronic diseases or cancers especially if applied as part of yearly health screenings in the future.
A gas-cooled reactor surface power system (1999)

A human outpost on Mars requires plentiful power to assure survival of the astronauts. Anywhere from 50 to 500 kW of electric power (kWe) will be needed, depending on the number of astronauts, level of scientific activity, and life-cycle closure desired. This paper describes a 250-kWe power system based on a gas-cooled nuclear reactor with a recuperated closed Brayton cycle conversion system. The design draws upon the extensive data and engineering experience developed under the various high-temperature gas cooled reactor programs and under the SP-100 program. The reactor core is similar in power and size to the research reactors found on numerous university campuses. The fuel is uranium nitride clad in Nb1%Zr, which has been extensively tested under the SP-I 00 program. The fuel rods are arranged in a hexagonal array within a BeO block. The BeO softens the spectrum, allowing better use of the fuel and stabilizing the geometry against deformation during impact or other loadings. The system has a negative temperature feedback coefficient so that the power level will automatically follow a variable load without the need for continuous adjustment of control elements. Waste heat is removed by an air-cooled heat exchanger using cold Martian air. The amount of radioactivity in the reactor at launch is very small (less than a Curie, and about equal to a truckload of uranium ore). The system will need to be engineered so that criticality cannot occur for any launch accident. This system is also adaptable for electric propulsion or life-support during transit to and from Mars.
Utilization capability of sucrose, raffinose and inulin and its less-sensitiveness to glucose repression in thermotolerant yeast Kluyveromyces marxianus DMKU 3-1042 (2011)

Kluyveromyces marxianus possesses a useful potential to assimilate a wide variety of substrates at a high temperature, but the negative effect by coexisting glucose is critical for utilization of biomass containing various sugars. Such a negative effect on the activity of inulinase, which is the sole enzyme to hydrolyze sucrose, raffinose and inulin, has been demonstrated in K. marxianus without analysis at the gene level. To clarify the utilization capability of sucrose, raffinose and inulin and the glucose effect on inulinase in K. marxianus DMKU 3-1042, its growth and metabolite profiles on these sugars were examined with or without glucose under a static condition, in which glucose repression evidently occurs. Consumption of sucrose was not influenced by glucose or 2-deoxyglucose. On the other hand, raffinose and inulin consumption was hampered by glucose at 30°C but hardly hampered at 45°C. Unlike Saccharomyces cerevisiae, increase in glucose concentration had no effect on sucrose utilization. These sugar-specific glucose effects were consistent with the level of inulinase activity but not with that of the KmINU1 transcript, which was repressed in the presence of glucose via KmMig1p. This inconsistency may be due to sufficient activity of inulinase even when glucose is present. Our results encourage us to apply K. marxianus DMKU 3-1042 to high-temperature ethanol fermentation with biomass containing these sugars with glucose.
An extended set of FORTRAN basic linear algebra subprograms (1988)

This paper describes an extension to the set of Basic Linear Algebra Subprograms. The extensions are targeted at matrix-vector operations that should provide for efficient and portable implementations of algorithms for high-performance computers.
A switched-capacitor interface for capacitive pressure sensors (2002)

A switched-capacitor interface of a capacitive pressure sensor is developed which provides linear digital outputs. It consists of a sample/hold circuit followed by a charge-balancing analog-to-digital converter. Two linearization methods based on the hyperbolic relation between the sensor capacitance and pressure are investigated in order to accommodate them to the basic interface configuration. In either method, linear digital outputs with an accuracy higher than 8-b are obtained. Because of its high accuracy and compatible fabrication process, the interface described is best suited for a smart silicon capacitive pressure sensor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Initiation Pathways in the Polymerization of Alkyl Methacrylates with tert-Butoxy Radicals (1982)

Abstract Tert-butoxy radicals, derived from the thermal decomposition of di-tert-butyl peroxalate at 60°C, react with methyl, ethyl, and n-butyl methacrylate by double-bond addition and by hydrogen abstraction from the α-methyl and ester alkyl functions. The proportion of each of these processes, as well as the fraction of tert-butoxy radicals that fragment to give methyl radicals, has been determined by analysis of the products that result on trapping the transient carbon-centered radicals with 1,1,3,3-tetramethylisoindoline-2-oxyl.
Design considerations in single-channel MOS analog integrated circuits-a tutorial (1978)

The design of single-channel MOS analog integrated circuits is discussed. Simple models are presented and approximate design equations are given for basic analog cells. The emphasis is on first-order analysis as a starting point for computer-aided design.
Bentonite Rods Assure Ground Rod Installation In Problem Soils (1980)

Ground rods are an effective means of obtaining and maintaining a low resistance to remote ground. However, present methods of installation fail in rocky or hardpan soils. A technique has been developed that assures installation regardless of the subsoil conditions and offers a reduction in resistance of up to 36% per rod.
Immunological Properties of Extraembryonic Human Mesenchymal Stromal Cells Derived from Gestational Tissue (2013)

Mesenchymal stromal cells (MSCs) have been isolated from many tissues, including gestational tissue. To date, a study comparing the properties and suitability of these cells in cell-based therapies is lacking. In this study, we compared the phenotype, proliferation rate, migration, immunogenicity, and immunomodulatory capabilities of human MSCs derived from umbilical cord lining (CL-MSCs), umbilical cord blood (CB-MSCs), placenta (P-MSCs), and Wharton's jelly (WJ-MSCs). Differences were noted in differentiation, proliferation, and migration, with CL-MSCs showing the highest proliferation and migration rates resulting in prolonged survival in immunodeficient mice. Moreover, CL-MSCs showed a prolongation in survival in xenogeneic BALB/c mice, which was attributed to their ability to dampen TH1 and TH2 responses. Weaker human cellular immune responses were detected against CL-MSCs and P-MSCs, which were correlated with their lower HLA I expression. Furthermore, HLA II was upregulated less substantially by CL-MSCs and CB-MSCs after IFN-γ stimulation. MSC types did not differ in indolamine 2,3-dioxygenase (IDO) expression after IFN-γ stimulation. Despite their lower IDO, HLA-G, and TGF-β1 expression, only CL-MSCs were able to reduce the release of IFN-γ by lymphocytes in a mixed lymphocyte reaction. In summary, CL-MSCs showed the best characteristics for cell-based strategies, as they are hypo-immunogenic and show high proliferation and migration rates. In addition, these studies show for the first time that although immunomodulatory molecules HLA-G, HLA-E, and TGF-β play an important role in MSC immune evasion, basal and induced HLA expression seems to be decisive in determining the immunogenicity of MSCs.
Performance analysis and improvement of na&#x00EF;ve Bayes in text classification application (2013)

Naive Bayes classifier is widely used in machine learning for its simplicity and efficiency. However, most of the existing work on naïve Bayes focused on improving the Bayes model itself or whether the “naïve assumption” is satisfied. In this paper, the performance of naïve bayes in text classification is analyzed and the corresponding results from different points of view is proposed, then an improving way for text classification with highly asymmetric misclassification costs is provided. Finally the related experiments proved the above proposed method were efficient.
Present state and prospect of the DHEA substitution therapy. (2005)

副腎ステロイドのDHEAは加齢とともに直線的低下を認め,老化指標,長生き指標としての有用性が報告されている.またDHEAには抗糖尿病,抗肥満,抗動脈硬化,抗骨粗鬆症などの有益な作用が報告されており,抗加齢療法としてのDHEA補充療法が試みられている.健康感,性欲,骨代謝,糖質代謝,体脂肪,血管内皮機能といった指標にある程度の有用性は認められているが,わが国独自のデータの集積が乏しく,今後の課題である.
Derivatives of Purinethiols. Purine Thiolcarbonates and Related Compounds<sup>1</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDerivatives of Purinethiols. Purine Thiolcarbonates and Related Compounds1Elizabeth Dyer and Howard S. BenderCite this: J. Med. Chem. 1964, 7, 1, 10–14Publication Date (Print):January 1, 1964Publication History Published online1 May 2002Published inissue 1 January 1964https://pubs.acs.org/doi/10.1021/jm00331a003https://doi.org/10.1021/jm00331a003research-articleACS PublicationsRequest reuse permissionsArticle Views94Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Critical Constants, Boiling Points, Triple Point Constants, and Vapor Pressures of the Six Isotopic Hydrogen Molecules, Based on a Simple Mass Relationship (1951)

First Page
RF Response of Superconducting-GMR Mixed Sensors, Application to NQR (2007)

When coupled to a Giant Magneto-Resistive (GMR) sensor, a superconducting loop containing a constriction can be a very sensitive device for magnetic field detection . The bandwidth of a GMR sensor is wide with only a limitation in the GHz regime mainly due to the ferromagnetic resonances of the free layer. We have studied the radiofrequency response of this mixed sensor and we present femtotesla-range sensitivity obtained up to 10 MHz. An application of this kind of sensor is Nuclear Quadrupolar Resonance (NQR) and low field Nuclear Magnetic Resonance (NMR). We present results showing that mixed sensors can be better than optimized resonant coils for frequencies below 10 MHz opening new possibilities not only for magnetic imaging and low field Nuclear Magnetic Resonance but also for a lot of applications of magnetic sensing in the RF domain.
Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase Fet3p: An unexpected role for intracellular chloride channels (1998)

GEF1 is a gene in Saccharomyces cerevisiae, which encodes a putative voltage-regulated chloride channel. gef1 mutants have a defect in the high-affinity iron transport system, which relies on the cell surface multicopper oxidase Fet3p. The defect is due to an inability to transfer Cu+ to apoFet3p within the secretory apparatus. We demonstrate that the insertion of Cu into apoFet3p is dependent on the presence of Cl-. Cu-loading of apoFet3p is favored at acidic pH, but in the absence of Cl- there is very little Cu-loading at any pH. Cl- has a positive allosteric effect on Cu-loading of apoFet3p. Kinetic studies suggest that Cl- may also bind to Fet3p and that Cu+ has an allosteric effect on the binding of Cl- to the enzyme. Thus, Cl- may be required for the metal loading of proteins within the secretory apparatus. These results may have implications in mammalian physiology, as mutations in human intracellular chloride channels result in disease.
Antioxidant ability of squid ink polysaccharides as well as their protective effects on deoxyribonucleic acid DNA damage in vitro (2013)

Squid ink polysaccharides (SIPS) were isolated from squid ink, a plentiful and multifunctional marine material, and were demonstrated to have amelioratory effects on cyclophosphamide-induced damage in internal organs of model animals by our previous reports. To further investigate the protective effects of SIPS on chemotherapeutic damage caused by cyclophosphamide, this paper evaluated the bioactivities of the marine polysaccharides with a view to their antioxidant ability and their protective effects on deoxyribonucleic acid (DNA) damage using tests such as hydroxyl radicals, reducing power assay and 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radicals, and pEGFP-N1 plasmid DNA treated with ultra violet (UV) plus H2O2. Data revealed that SIPS not only quenched hydroxyl radicals and 1,1-Diphenyl-2-picrylhydrazyl radicals, but showed its strong reducing power and also suppressed oxidative scission on plasmid DNA strand caused by hydroxyl radicals which originated from H2O2shown by UV.   Key words: Squid ink polysaccharides (SIPS), antioxidant ability, deoxyribonucleic acid (DNA) damage.
E2s: structurally economical and functionally replete (2010)

Ubiquitination is a post-translational modification pathway involved in myriad cellular regulation and disease pathways. The Ub (ubiquitin) transfer cascade requires three enzyme activities: a Ub-activating (E1) enzyme, a Ub-conjugating (E2) enzyme, and a Ub ligase (E3). Because the E2 is responsible both for E3 selection and substrate modification, E2s function at the heart of the Ub transfer pathway and are responsible for much of the diversity of Ub cellular signalling. There are currently over 90 three-dimensional structures for E2s, both alone and in complex with protein binding partners, providing a wealth of information regarding how E2s are recognized by a wide variety of proteins. In the present review, we describe the prototypical E2-E3 interface and discuss limitations of current methods to identify cognate E2-E3 partners. We present non-canonical E2-protein interactions and highlight the economy of E2s in their ability to facilitate many protein-protein interactions at nearly every surface on their relatively small and compact catalytic domain. Lastly, we compare the structures of conjugated E2~Ub species, their unique protein interactions and the mechanistic insights provided by species that are poised to transfer Ub.
Radiation Rescue: Mesenchymal Stromal Cells Protect from Lethal Irradiation (2011)

Our data revealed that systemically administered MSCs provoke a protective mechanism counteracting the inflammatory events and also supporting detoxification and stress management after radiation exposure. Further our results suggest that MSCs, their release of trophic factors and their HSC-niche modulating activity rescue endogenous hematopoiesis thereby serving as fast and effective first-line treatment to combat radiation-induced hematopoietic failure.
Handbook of Environmental Fate and Exposure Data: For Organic Chemicals, Volume III Pesticides (1991)

This 5-volume set allows you to assess the health and environmental effects of chemicals by determining the routes of exposure of the chemical to sensitive organisms. Environmental Fate and Exposure of Organic Chemicals provides relevant facts on how individual chemicals behave in the environment and how humans and environmental organisms are exposed to the chemicals during their production, rise, transport, and disposal.Each chemical is prepared by one of the best-known organizations in environmental fate and exposure and is peer-reviewed by a panel of expert scientists. The information on each chemical includes all experimental values and references for physical properties, all chemical fate studies, and all available monitoring data and interpretative summaries.
Quantum memory and gates using a <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi mathvariant="normal">Λ</mml:mi></mml:math>-type quantum emitter coupled to a chiral waveguide (2018)

By coupling a $\mathrm{\ensuremath{\Lambda}}$-type quantum emitter to a chiral waveguide, in which the polarization of a photon is locked to its propagation direction, we propose a controllable photon-emitter interface for quantum networks. We show that this chiral system enables the swap gate and a hybrid-entangling gate between the emitter and a flying single photon. It also allows deterministic storage and retrieval of single-photon states with high fidelities and efficiencies. In short, this chirally coupled emitter-photon interface can be a critical building block toward a large-scale quantum network.
Asterogynins: Secondary Metabolites from a Costa Rican Endophytic Fungus (2010)

An endophytic fungus isolated from the small palm Asterogyne martiana produced two unusual steroid-like metabolites, asterogynin A (1) and asterogynin B (2), along with the known compounds viridiol (3) and viridin (4). Asterogynins A and B were characterized by NMR and MS spectroscopic analysis.
Persistent <i>Campylobacter jejuni</i> Infection in an Immunocompromised Patient (1984)

Recurrent bacteremia and enteritis due to a specific serotype of Campylobacter jejuni occurred over a 12-month period in a patient on hemodialysis with systemic lupus erythematosus who was also deficient in serum IgA and IgM. A bactericidal defect in the patient's sera for C. jejuni was shown. A role for immunoglobulins in the host response to C. jejuni is suggested, in that the IgA deficiency may have predisposed the patient to chronic gastrointestinal carriage and because the resolution of the bacteremia corresponded with the delayed appearance in the blood of IgG specific for the infecting strain.
Characterization of a mouse strain expressing Cre recombinase from the 3′ untranslated region of the dopamine transporter locus (2006)

Dopamine (DA) neurotransmission has been implicated in several neurological and psychiatric disorders. The dopamine transporter (DAT) is highly expressed in dopaminergic neurons of the ventral mesencephalon and regulates neurotransmission by transporting DA back into the presynaptic terminals. To mediate restricted DNA recombination events into DA neurons using the Cre/loxP technology, we have generated a knockin mouse expressing Cre recombinase under the transcriptional control of the endogenous DAT promoter. To minimize interference with DAT function by preservation of both DAT alleles, Cre recombinase expression was driven from the 3' untranslated region (3'UTR) of the endogenous DAT gene by means of an internal ribosomal entry sequence. Crossing this murine line with a LacZ reporter showed colocalization of DAT immunocytochemistry and beta-galactosidase staining in all regions analyzed. This knockin mouse can be used for generating tissue specific knockouts in mice carrying genes flanked by loxP sites, and will facilitate the analysis of gene function in dopaminergic neurons.
PHYTOCHELATINS (1990)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More