gebhart/patrepeval huggingface dataset:
Protective Effect of JTV519, A New 1,4-Benzothiazepine Derivative, on Prolonged Myocardial Preservation (1999)

As an adjunct to cardioplegia, JTV519 showed a significant protective effect on myocardium undergoing 6 hours of ischemia. The beneficial protective effects of JTV519 are correlated with its ability to inhibit the postischemic rise in intracellular calcium.
Synthesis, Crystal Structures and Properties of Three New Tetrathiomolybdates with Organic Ammonium Cations (2004)

Abstract Three new tetrathiomolybdates (pipH 2 )[MoS 4 ] (1), (trenH 2 )[MoS 4 ]·H 2 O (2) and [(prop) 4 N] 2 - [MoS 4 ] (3) (pip = piperazine, tren = tris(2-aminoethyl)amine and prop = n-propyl) were synthesized and characterized by elemental analysis, infrared spectroscopy, single crystal X-ray crystallography, and thermoanalysis. All compounds were prepared by the base promoted cation exchange method, i.e. by the reaction of the ammonium salt of [MoS 4 ] 2− with the corresponding organic amine or organic ammonium hydroxide. In the compounds 1 and 2 the organic amines pip and tren are diprotonated and they are linked to the tetrahedral [MoS 4 ] 2− dianions through weak hydrogen bonding interactions. The strength and number of these hydrogen bonds affect the Mo-S bond lengths and a relatively long Mo-S bond of 2.2114(8) Å is observed in 1 while the longest Mo-S bond in 2 is 2.1951(5) Å . In compound 3 no S···H-N interactions are possible and the Mo-S bond lengths scatter in a more narrow range compared to those in compounds 1 and 2. The thermal behavior was investigated using differential thermal analysis and thermogravimetry. On heating compound 1 decomposes in two closely related steps while 2 loses first the crystal water followed by the decomposition of the tetrathiomolybdate. The final products are amorphous molybdenum sulfides. The decomposition of compound 3 yields a very porous material with sponge-like morphology.
Selective photothermolysis of the sebaceous glands for acne treatment (2002)

ICG and diode laser treatment is a new approach for the treatment of acne based on experimentally observed selective photothermolysis of the sebaceous glands.
Near field optics and its application to optical memory (1998)

This paper explains the principle of near field optics and lists the problem of high density optical memory for which a storage density of 1 Tbit/inch2 is expected as an application. Furthermore, the possibility of tracking avoidance is introduced in storage and read out, especially the latter, by using a planar probe array. The present status of probe array fabrication discussed. © 1998 Scripta Technica, Electron Comm Jpn Pt 2, 81(8): 41–48, 1998
Pt‐IrO<sub>2</sub>nanorod array electrode for oxygen evolution in PEM water electrolysis cell (2012)

ABSTRACT Pt‐IrO 2 nanorod arrays supported on the carbon paper were fabricated directly using the dip‐coating/calcination method. The nanorod arrays and ordering were characterized by scanning electron microscope. Pt‐IrO 2 /carbon paper directly used as catalyst layer and support layer with the united structure on the anode side is demonstrated to have excellent electrocatalytic activity for oxygen evolution in proton exchange membrane (PEM) water electrolysis cell. By employing the Pt‐IrO 2 (Pt:Ir = 3:7) at anode and commercial 20% Pt/C catalysts at cathode, a cell voltage as low as 1.86 V was achieved under high current density with the total noble metal loading of 0.8 mg cm −2 . The Pt‐IrO 2 electrocatalysts with uniform nanorod arrays structure, good conductivity are supposed to play a key role for their enhanced catalytic activity toward oxygen evolution reaction. The study in this work might open an opportunity for the efficient utilization of valuable catalytic materials in PEM water electrolysis by decreasing the catalyst loading and provide a facile route to fabricate electrode based on direct calcination of noble metal and metal oxide nanoparticles onto carbon paper. © 2012 Curtin University of Technology and John Wiley & Sons, Ltd.
Natural Heat-Sinking Control Method for High-Speed Actuation of the SMA (2006)

This paper describes two methodologies for increasing the actuation speed of the shape memory alloy (SMA) actuator in ambient environment. The first method involves the implementation of a simple, light-weight heat sink, which consists only of a combination of an outer metal tube with the silicone grease, but able to cool the heated alloy effectively. The second method describes a high current pulse actuation that actuates the alloy fastly using pulses in the milliseconds order. We hypothesize that a fast actuation of the SMA results in small increase in temperature, due to energy transformation from heat energy to the kinetic energy in the SMA. This new heating method revolutionizes the actuation of the alloy for a significantly faster response.
Construction of a Highly Dependable Operating System (2006)

It has been well established that most operating system crashes are due to bugs in device drivers. Because drivers are normally linked into the kernel address space, a buggy driver can wipe out kernel tables and bring the system crashing to a grinding halt. We have greatly mitigated this problem by reducing the kernel to an absolute minimum and running each driver as a separate, unprivileged user-mode process. In addition, we implemented a POSIX-conformant operating system, MINIX 3, as multiple user-mode servers. In this design, a server or driver failure no longer is fatal and does not require rebooting the computer. This paper discusses how we designed and implemented the system, which problems we encountered, and how we solved these problems. We also discuss the performance effects of our changes and evaluate how our multiserver design improves operating system dependability over monolithic designs
Open-ended coaxial-line technique for the measurement of the microwave dielectric constant for low-loss solids and liquids (1993)

A system which enables fast and reliable measurements of the dielectric constant over continuous microwave frequency ranges for both solid and liquid low-loss materials is described. The main thrust of this work is the application of the open-ended coaxial-line probe technique, which has been used previously for soft biological materials, to low-loss solid samples. Using the instrumentation and procedure presented here, the dielectric constant for low-loss solids can be measured absolutely to ±2%–3% with routine care. The uncertainty can be reduced by about a factor of 2 by averaging several measurements. It is also smaller for liquid samples. This application features the use of relatively simple and readily available microwave components. Also, it is shown that a simple empirical relationship can be used to obtain the bulk dielectric constant from samples of a material in the form of thin slabs. The experimental results which are presented here for kapton, Teflon, Corning glass No. 0211, soda lime glass, magnesium oxide, sapphire, silicon, alumina, and lanthanum aluminate, as well as carbon tetrachloride, compare favorably with existing literature values.
On the use of pitch power spectrum in the evaluation of vocal tremor (1988)

A point process model of the speech excitation wave for sustained vowels has been formulated, where the pitch is modulated by a physiological disturbance (vocal tremor). It has been demonstrated that the power spectrum of an impulse train, representing the glottal pulses, is composed of a periodic replication of the spectrum of the modulating signal, accompanied by an impulse train at the carrier frequency. Hence, the power spectrum of the vocal tremor can be estimated from the pitch. A trend location algorithm has been developed to locate and remove local trends from the signal prior to the evaluation of the pitch power spectrum. Thus, spectral representation of the speech excitation enables estimation of vocal tremor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Troponin Levels Help Predict New-Onset Atrial Fibrillation in Ischaemic Stroke Patients: A Retrospective Study (2009)

Moderately elevated troponin levels in acute ischaemic stroke are independently associated with NAF.
Interference Channels With Arbitrarily Correlated Sources (2011)

Communicating arbitrarily correlated sources over interference channels is considered in this paper. A sufficient condition is found for lossless transmission of a pair of correlated sources over a discrete memoryless interference channel. With independent sources, the sufficient condition reduces to the Han-Kobayashi achievable rate region for interference channels. For sources with a special correlation structure, the proposed region reduces to the known achievable region for interference channels with common information. Moreover, the proposed coding scheme is optimal for transmitting such set of correlated sources over a class of deterministic interference channels as defined in El Gamal and Costa, 1982.
Physiologically Based Pharmacokinetic Modeling: A Tool for Understanding ADMET Properties and Extrapolating to Human (2013)

Physiologically Based Pharmacokinetic Modeling: A Tool for Understanding ADMET Properties and Extrapolating to Human
A theory of catadioptric image formation (2002)

Conventional video cameras have limited fields of view which make them restrictive for certain applications in computational vision. A catadioptric sensor uses a combination of lenses and mirrors placed in a carefully arranged configuration to capture a much wider field of view. When designing a catadioptric sensor, the shape of the mirror(s) should ideally be selected to ensure that the complete catadioptric system has a single effective viewpoint. In this paper, we derive the complete class of single-lens single-mirror catadioptric sensors which have a single viewpoint and an expression for the spatial resolution of a catadioptric sensor in terms of the resolution of the camera used to construct it. We also include a preliminary analysis of the defocus blur caused by the use of a curved mirror.
Regulation of plant defense responses in Arabidopsis by EDR2, a PH and START domain‐containing protein (2005)

We have identified an Arabidopsis mutant that displays enhanced disease resistance (edr2) to the biotrophic powdery mildew pathogen Erysiphe cichoracearum. Inhibition of fungal growth on edr2 mutant leaves occurred at a late stage of the infection process and coincided with formation of necrotic lesions approximately 5 days after inoculation. Double-mutant analysis revealed that edr2-mediated resistance is suppressed by mutations that inhibit salicylic acid (SA)-induced defense signaling, including npr1, pad4 and sid2, demonstrating that edr2-mediated disease resistance is dependent on SA. However, edr2 showed normal responses to the bacterial pathogen Pseudomonas syringae pv. tomato strain DC3000. EDR2 appears to be constitutively transcribed in all tissues and organs and encodes a novel protein, consisting of a putative pleckstrin homology (PH) domain and a steroidogenic acute regulatory protein-related lipid-transfer (START) domain, and contains an N-terminal mitochondrial targeting sequence. The PH and START domains are implicated in lipid binding, suggesting that EDR2 may provide a link between lipid signaling and activation of programmed cell death mediated by mitochondria.
Motion information based adaptive block classification for fast motion estimation (2008)

An object based fast search motion estimation algorithm is considered to be efficient since the computation of motion search can concentrate on blocks with moving object. However, the computational complexity of object segmentation is still too high to be applied on fast search motion estimation. In this paper, we propose an adaptive block classification algorithm. With this method, the fast search algorithm for motion estimation can make use of characteristics of motion information of the sequence being coded efficiently. In our approach, the statistical information which features the motion activities of the blocks in the previous frame is used to predict the characteristics of the motion activities of the blocks in the current frame. This is to re-assign the computation of motion search to locations that deserve to be searched more than others. Extensive experimental work has been done, results of which show that the adaptive block classification approach can accelerate the current fast search motion estimation algorithm with little decrease (0.01dB to 0.09dB for 8 standard test sequences) or sometimes, even increase (0.01dB to 0.17dB for 10 other standard test sequences) on resultant video quality, the peak signal-to-noise ratio (PSNR), while our fast algorithm is 150 times over the exhaustive full search algorithm on average.
Combination of low‐dose mirtazapine and ibuprofen for prophylaxis of chronic tension‐type headache (2007)

Chronic headaches are difficult to treat and represent the biggest challenge in headache centres. Mirtazapine has a prophylactic and ibuprofen an acute effect in tension-type headache. Combination therapy may increase efficacy and lower side effects. We aimed to evaluate the prophylactic effect of a combination of low-dose mirtazapine and ibuprofen in chronic tension-type headache. Ninety-three patients were included in the double-blind, placebo-controlled, parallel trial. Following a 4-week run-in period they were randomized to four groups for treatment with a combination of mirtazapine 4.5 mg and ibuprofen 400 mg, placebo, mirtazapine 4.5 mg or ibuprofen 400 mg daily for 8 weeks. Eighty-four patients completed the study. The primary efficacy parameter, change in area under the headache curve from run-in to the last 4 weeks of treatment, did not differ between combination therapy (190) and placebo (219), P = 0.85. Explanatory analyses revealed worsening of headache already in the third week of treatment with ibuprofen alone. In conclusion, the combination of low-dose mirtazapine and ibuprofen is not effective for the treatment of chronic tension-type headache. Moreover, the study suggests that daily intake of ibuprofen worsens headache already after few weeks in chronic tension-type headache.
Comparison of Subcutaneous Sumatriptan with Usual Acute Treatments for Migraine (1995)

246 migraine patients (International Headache Society definition, 1-6 severe attacks per month) were randomised into a multicentre, cross-over study comparing subcutaneous (s.c.) sumatriptan 6 mg administered by an auto-injector (Glaxo device) with usual acute migraine treatments. Patients were treated for 2 months or up to 12 attacks, and then crossed over to the alternative treatment for the same duration. Usual treatments were: analgesics (including combinations), 49%; ergotamine, 24%; NSAIDs 19%; DHE, 7%. Rescue medication was allowed 2 h after the first dose. Headache was assessed on a 4-point self-rating scale (0: none, 1: mild, 2: moderate, 3: severe). Other migraine symptoms were assessed as present or absent. Quality of life was assessed before the study and at the end of each treatment period. Two hundred and seventeen patients were eligible for the cross-over analysis. At 2 h post-dosing, an average of 78% of attacks per patient were successfully relieved (grade 3 or 2 to 1 or 0) by s.c. sumatriptan, compared with 34% for the usual treatments (p < 0.001) and 63% of attacks per patient were completely relieved (grade 0) by s.c. sumatriptan compared with 15% for the usual treatments (p < 0.001). Sumatriptan-treated patients used rescue medication for 19% of their attacks, compared to 59% for comparator drugs (p = 0.001). Results for patient preference were: s.c. sumatriptan, 85%; usual treatments, 10%; no preference, 5% (p < 0.001). Sumatriptan was significantly superior to comparator drugs for all other efficacy end-points (p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
Comparison of Selegiline and Rasagiline Therapies in Parkinson Disease: A Real-life Study (2016)

The similarity in time to levodopa in both groups suggests no differences between selegiline and rasagiline in their effect on the natural history of PD. A possible interaction effect between rasagiline and DA might exist. A better symptomatic profile of selegiline more than that of rasagiline in the earlier stages of PD may explain the difference between the 2 groups in time to DA initiation.
Fractional administration of adriblastin and modified route of ara-C administration for the treatment of acute leukaemia. (1985)

Two groups of AML patients (n1 = 63, n2 = 20) and two groups of ALL patients (n1 = 33, n2 = 15) were treated using polychemotherapy protocols which in each leukaemia subtype differed mainly in adriblastin administration being either in bolus form (30 mg/m2/day i.v.) or fractional form at the beginning 20 mg i.v., then 6 mg/m2 every 6 h. The fractional method of administration was elaborated on experimental data indicating the superiority of continuous infusion of anthracyclines. In AML additional ara-C was given in continuous infusion only on 1 to 3 days, on 4 to 8 days duplicated dose was administered subcutaneously (i.e. 100 mg/m2 every 12 h). In patients given fractional doses of adriblastin and in AML also ara-C in the modified way the statistical analysis revealed a higher CR (ALL - 67%/93%, AML - 46%/60%) and CR + PR rates, a lower rate of infections as the cause of death in the AML group, lower rates of nausea and vomiting as well a lower increase of infections in the course of the induction treatment in the AML group. Another advantage was a lower total dose of adriblastin for remission induction treatment as well as an elevated cumulative dose which allows anthracyclines to be longer used. The efficacy of the modified ara-C administration confirms our earlier observation.
Removal of fluoride ions from aqueous solutions by multivalent metal compounds (1995)

The removal of fluoride ions by Al(III) ion, Ca(II) ion and solid compounds of multivalent metal elements such as Al(III), Y(III), La(III), Ce(III), Nd(III), Sm(III), Gd(III), Si(IV), Ti(IV), Zr(IV) and Ce(IV) in the form of oxides, hydrous oxides and basic carbonates is studied. With an excess amount (20 mM) of Ca or Al ion, fluoride was removed from 5.0 to < 0.02 mM by precipitation (pH 4‐) and coprecipitation (pH 5.5–7.5), respectively. With a small dose, the solid trivalent metal compounds were effective in decreasing the fluoride concentration to < 0.02 mM below a certain pH. The dissolution of the material became appreciable at a pH where the lowest fluoride concentration was attained. Among the tetravalent metal compounds, only hydrous cerium(IV) oxide was effective in removing fluoride ions without a significant dissolution even at pH 2. It is suggested that fluoride ions are removed mainly by an ion exchange process with surface hydroxide groups in a neutral pH range, but by both ion exchange and precipitation processes in the lower pH range. These solid multivalent metal compounds can be used for the treatment of fluoride‐containing wastewater from industries, such as those manufacturing semiconductors, and fluoride can be reduced to the permissible level.
Studies on Benzoheterocyclic Derivatives. XIII. Synthesis and Pharmacological Actions of Indoline Derivatives.(4) (1973)

Thirty one derivatives of 3-alkoxy-1[ω-(N-substituted amino)-3-phenylindolin-2-one and related compounds were synthesized for pharmacological testing. As a preliminary screening test compounds were tested for analgetic-antiphlogistic activity by anti-writhing test in mice. Acute toxicity and gross behavioral changes in mice were also determined. The majority of the compounds produced anti-writhing activity.
Total synthesis of (.+-.)-fawcettimine (Burnell's base A) (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (.+-.)-fawcettimine (Burnell's base A)Clayton H. Heathcock, Karl M. Smith, and Todd A. BlumenkopfCite this: J. Am. Chem. Soc. 1986, 108, 16, 5022–5024Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/ja00276a062https://doi.org/10.1021/ja00276a062research-articleACS PublicationsRequest reuse permissionsArticle Views1561Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Site-dependent differences in transmittance and UV-B-absorbing capacity of isolated leaf epidermes and mesophyll in Urginea maritima (L.) Baker (1999)

The spectral transmittance of isolated ‘intact’ upper and lower epidermes as well as the extractable UV-B-absorbing capacity of epidermes and mesophyll were studied in the leaves of exposed and deeply shaded, field-grown plants of Urginea maritima (L.) Baker. Epidermal transmittance in the visible part of the spectrum was high (>80%) in all cases. Transmittance in the UV-B (280–320 nm) was comparatively high (c. 14%) in both the upper and lower epidermes of shaded plants, but more than an order of magnitude lower in exposed plants, with the lowest values observed on the upper leaf epidermis. UV-B transmittance was negatively correlated with the methanol extractable UV-B-absorbing capacity of the epidermes, but was independent of epidermal thickness. The UV-B-absorbing capacity of the mesophyll, when expressed on an area basis, was not affected by exposure. However, it was significantly higher in shaded plants, when expressed on a dry mass basis. The results indicate that although the concentrations of the UV-B-absorbing components of the whole leaf or its epidermis fluctuate according to the site-dependent radiation stress, the opposite is evident for the mesophyll. Therefore, high irradiance in U. maritima, apart from inducing an increase in UV-B-absorbing compounds on a whole leaf basis, also caused a change in the distribution of these compounds between epidermis and mesophyll.
International advances in outcome measurement in palliative care: One step closer to cross-national comparisons of routinely collected outcome data in palliative care (2015)

The Palliative Care Outcomes Collaboration (PCOC), Australia, and the Outcome Assessment and Complexity Collaborative (OACC), UK, are initiatives that support the routine use of outcome measures in specialist palliative care. Both initiatives follow a sophisticated implementation approach, facilitating routine clinical assessment tools that can be used to measure and benchmark patient outcomes. Both projects also provide feedback to participating services and encourage the use of outcomes data for service development.
Risk stratification of periprocedural myocardial infarction after percutaneous coronary intervention: Analysis based on the <scp>SCAI</scp> definition (2017)

Age, multivessel treatment, at least one bifurcation treatment, and total treated lesion length are predictive of PMI. The PMI score could help identify patients at high risk of PMI after PCI. © 2017 Wiley Periodicals, Inc.
Géographie humaine et économie politique (1951)

George Pierre. Géographie humaine et économie politique. In: Revue économique, volume 2, n°1, 1951. pp. 103-108.