gebhart/patrepeval huggingface dataset:
IntervenÃ§Ã£o de O.V.P (2018)

Essa pesquisa investiga questAµes relacionadas A  adolescAancia e sua temporalidade frente A  intervenA§Aµes aplicadas com o  objetivo de criar um espaA§o temporal transicional perpassado por elementos de holding para a situaA§A£o da escolha profissional de adolescentes, sob o ponto de vista winnicottiano ,na modalidade de â€œworkshopâ€, com estudantes do Curso Especial PrA©- Vestibular da UEL(CEPV).O local :Uel . PopulaA§A£o envolvida: equipe de 2 graduandos, bolsistas do curso de Psicologia, 1 colaboradora externa psicA³loga e o coordenador docente. Do total de vestibulandos convidados, participaram 68 adolescentes, sendo 25 do sexo masculino e 43 do sexo feminino. Metodologia aplicada, palestra ministrada, com o tema. â€œSonhos e carreiras profissionaisâ€, para respostas livres em formulAirio sobre sonhos e profissA£o; testes psicolA³gicos de avaliaA§A£o sobre interesses e amadurecimento sobre a escolha profissional. Os resultados atenderam as premissas teA³ricas e tA©cnicas, com elementos de holding durante todo o processo. Ainda em fase de avaliaA§A£o, jAi podemos concluir previamente que, cumpriu uma funA§A£o psicoprofilAitica muito importante, atA© a situaA§A£o temporal atual. Bem como a comprovaA§A£o eficaz de um espaA§o temporal transicional.
A liquid perfluorochemical decreases the in vitro production of reactive oxygen species by alveolar macrophages (1995)

Exposure of alveolar macrophages to perfluorooctylbromide in vitro decreases the responsiveness of macrophages to potent stimuli. This finding may partially explain the decrease in pulmonary inflammation seen in animals treated with partial liquid ventilation during experimentally induced lung injury.
Designing mega-ASICs in nanogate technologies (2003)

This paper discusses challenges the designer faces in integrating entire system product designs, containing tens or even hundreds of millions of logic gates, into single chip solutions now within reach using circuit densities possible in the latest silicon technologies. Managing designs of this size presents a new dimension of issues, and managing the physical and electrical effects of these high density device geometries presents another; solutions in both these areas are presented. Lastly, this paper discusses the integration of multiple functional components (previously organized as systems of multiple chips from multiple design sources and technologies) into a single chip product.
Ex Vivo Renal Surgery and Autotransplantation: A Preliminary Report (1974)

No AccessJournal of Urology1 Feb 1974Ex Vivo Renal Surgery and Autotransplantation: A Preliminary Report Robert W. Taylor, Lynn H. Banowsky, and Thomas A. Borden Robert W. TaylorRobert W. Taylor More articles by this author , Lynn H. BanowskyLynn H. Banowsky Current address: Cleveland Clinic, Cleveland, Ohio. More articles by this author , and Thomas A. BordenThomas A. Borden More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)59912-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1974 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByMcLoughlin M and Williams G (2018) Renal Aneurysmectomy in the Ex Vivo SettingJournal of Urology, VOL. 118, NO. 1 Part 1, (15-16), Online publication date: 1-Jul-1977.McLoughlin M (2018) The Treatment of Bilateral Synchronous Renal Pelvic Tumors with Bench SurgeryJournal of Urology, VOL. 114, NO. 3, (463-465), Online publication date: 1-Sep-1975.Williams G (2018) CommentJournal of Urology, VOL. 114, NO. 3, (465-465), Online publication date: 1-Sep-1975. Volume 111Issue 2February 1974Page: 148-150 Advertisement Copyright & Permissions© 1974 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Robert W. Taylor More articles by this author Lynn H. Banowsky Current address: Cleveland Clinic, Cleveland, Ohio. More articles by this author Thomas A. Borden More articles by this author Expand All Advertisement PDF DownloadLoading ...
Event Detection Challenges, Methods, and Applications in Natural and Artificial Systems (2009)

A system is a combination of elements whose collaborative actions produce results generally not attainable by the elements acting alone, and an event is a significant occurrence or large-scale activity that is unusual relative to normal patterns of behavior. Event detection, or the process of identifying the occurrence of an event, within both natural and artificial (or man-made) systems has long been a topic of research, and a variety of techniques have been developed to address event detection problems. This article is a treatise on the topic of event detection and a prequel to research previously conducted by the authors regarding the application of robust metamodels to uncertainty quantification and event detection within a geophysical system. The article explores the most common difficulties and challenges in event detection problems, describes the event detection methods most frequently employed, and provides example event detection applications in both natural and artificial systems. It incorporates the discoveries of and lessons learned by multiple researchers and authors over many combined years of experience in event detection theory and application; this rather broad study has never been previously published within a single volume. the article concludes with an examination of the intimate relationship and indivisible link between event detection and modeling and simulation.
Neuromuscular disorders : clinical and molecular genetics (1998)

Molecular genetics of muscular disorders congenital muscular dystrophies Duchenne & Becker muscular dystrophies Emery-Dreifuss muscular dystrophy facioscapulohueral muscular dystrophy limb girdle muscular dystrophies oculo-pharyngeal muscular dystrophy distal myopathies and related disorders mitochondrial myopathies central core disease desminopathies nemaline myopathy myotubular myopathy fibrodysplasia ossificans progressiva myotonic dystrophy non-dystrophic myotonias spinal muscular atrophy familial ALS congenetial myasthenic syndromes hereditary neuropathies post-polio muscle dysfunction.
Open label trial of tamoxifen in scleroderma. (2003)

Based on these results, we would not recommend tamoxifen for further large scale studies in scleroderma.
Phorbol ester modulation of integrin-mediated cell adhesion: a postreceptor event. (1989)

Chinese hamster ovary (CHO) suspension culture cells adhere readily to substrata coated with extracellular matrix proteins such as fibronectin, vitronectin, or laminin. In the case of fibronectin, it is known that adhesion is mediated by an integrin-type, cell surface fibronectin receptor (FnR). We demonstrate here that treatment of CHO cells with submicromolar concentrations of phorbol ester produces a remarkable increase in the ability of these cells to adhere to fibronectin. Both the rate of adhesion and the efficiency of adhesion are enhanced about four- to fivefold. Further, phorbol ester treatment renders the fibronectin-mediated adhesion process less sensitive to inhibitors, including GRGDSP peptide and PB1, a monoclonal anti-FnR antibody. By contrast, nonspecific adhesion processes, for example cell attachment to substrata coated with polylysine or concanavalin A, are not affected by phorbol ester treatment. Thus integrin-mediated adhesion is modulated by phorbol esters, but nonspecific adhesion is not. Neither the number of cell surface FnRs nor the receptor affinity, as measured by 125I-fibronectin and 125I-anti-FnR antibody binding, is altered by phorbol ester treatment. Thus, the effect of phorbol ester on cell adhesion seems to occur at a step subsequent to initial ligand-receptor binding events. Since phorbol ester is a potent activator of protein kinase C, we examined phosphorylation patterns in control and phorbol-treated cells. In immunoprecipitates of lysates from suspension culture cells, there was no evidence of phorbol ester-stimulated phosphorylation of FnR or of talin, a protein thought to interact with FnR. These results suggest that phorbol ester effects on fibronectin-dependent adhesion are not due to phosphorylation of the FnR itself but rather may be due to postreceptor events, possibly the phosphorylation of cytoskeletal proteins involved in integrin-mediated adhesion.
Isolation of the non-glycosylated proteins of desmosomes and immunolocalization of a third plaque protein: desmoplakin III. (1985)

The cytoplasmic plaque of the spot desmosome or macula adhaerens mediates the attachment of bundles of intermediate filaments to the plasma membrane. We have isolated from a bovine epidermal desmosome preparation a fraction that is highly enriched in the non-glycosylated desmosomal proteins. Plastic-embedded and thin-sectioned high-speed pellets of this fraction reveal closely packed filaments that resemble plaque regions of the low pH whole desmosome preparation from which they are derived. NaDodSO4/polyacrylamide gel electrophoresis reveals four major, non-glycosylated proteins of 240, 210, 81, and 77 kDa. In agreement with a previous study, we find the 240- and 210-kDa proteins (desmoplakins I and II) to be closely related, whereas the 81- and 77-kDa proteins are unique. This is shown both immunologically and by one-dimensional proteolytic peptide mapping. Monospecific, polyclonal rabbit antibodies were prepared against the 81-kDa protein and used, in conjunction with protein A-complexed colloidal gold particles (PAG), to immunolocalize this antigen on ultrathin sections of bovine muzzle epidermis. On antibody-labeled sections, PAG particles were associated principally with the desmosomal cytoplasmic plaque. Sections exposed to preimmune serum showed little or no labeling. We conclude that the 81-kDa protein, like the 240/210-kDa protein family, is one of the major components of the desmosomal plaque. We designate it as "desmoplakin III." The location of the 77-kDa protein remains to be definitively established.
6β-Acetoxynortropane:  A Potent Muscarinic Agonist with Apparent Selectivity toward M<sub>2</sub>-Receptors (1998)

A series of tropane derivatives, related in structure to baogongteng A (1), an alkaloid from a Chinese herb, were synthesized. 6beta-Acetoxynortropane (5) had weak affinity (Ki 22 microM) for central (M1) muscarinic receptors in a [3H]quinuclidinyl benzilate binding assay but had extremely high affinity (Ki 2.6 nM) and selectivity for M2-muscarinic receptors expressed in CHO cells. It had 13-fold lower affinity for M4-receptors, 260-fold lower affinity for M3-receptors, and 8200-fold lower affinity for M1-receptors expressed in CHO cells. The 6beta-carbomethoxy analogue (14) of baogongteng A had only weak affinity for M2-muscarinic receptors, as did 6beta-carbomethoxynortropane (13) and 6beta-acetoxytropane (4). In transfected CHO cells, 6beta-acetoxynortropane (5) was an agonist at M2-receptors, based on a GTP-elicited decrease in affinity, and a full agonist with an IC50 of 11 nM at M4-receptors, based on inhibition of cyclic AMP accumulation, while being a full agonist at M1-receptors with an EC50 of 23 nM and a partial agonist at M3-receptors with an EC50 of 3.6 nM, based in both cases on stimulation of phosphoinositide breakdown. All of the 16 tropane derivatives had weak affinities for central alpha4beta2-nicotinic receptors with 6beta-carbomethoxynortropane (13) having the highest affinity, which was still 150-fold less than that of nicotine. 6beta-Acetoxynortropane (5) represents a potent muscarinic agonist with apparent selectivity toward M2-receptors.
An electronic device for accelerating bone formation in tissues surrounding a dental implant (2009)

A dental implant is a unique structure which can be used with a noninvasive method because it is inserted into the bone in part and extended extracorporally. This study presents an electronic device that is temporarily connected with the dental implant, and reports its effect on accelerating bone formation in the surrounding tissues in a canine mandibular model. A small sized and low power consumption biphasic electrical current (BEC) stimulator ASIC was developed and the surrounding tissue was exposed to continuous BEC stimulation for 7 days with the parameters of 20 microA/cm(2), 125 micros duration, and 100 pulses/s. After 2 (n = 5) and 5 weeks (n = 5), animals were sacrificed and the specimens were histomorphometrically evaluated. The newly formed bone area (BA) was 1.30 times (3 weeks, P < 0.05) and 1.35 times (5 weeks, P < 0.05) higher in the experimental group compared to the control group, respectively. Bone-implant contact (BIC) in 3-week specimens was 1.62 times (P < 0.05) greater in the experimental group, while there was no statistically significant difference in 5-week specimens. Based on these results showing accelerated bone formation on and around the dental implant, it could be suggested that the latent time for osseointegration in dental implants can be reduced, and the success rate of implants in poor quality bone can be increased by using our device with BEC.
Fast and Scalable Minimal Perfect Hashing for Massive Key Sets (2017)

Minimal perfect hash functions provide space-efficient and collision-free hashing on static sets. Existing algorithms and implementations that build such functions have practical limitations on the number of input elements they can process, due to high construction time, RAM or external memory usage. We revisit a simple algorithm and show that it is highly competitive with the state of the art, especially in terms of construction time and memory usage. We provide a parallel C++ implementation called BBhash. It is capable of creating a minimal perfect hash function of $10^{10}$ elements in less than 7 minutes using 8 threads and 5 GB of memory, and the resulting function uses 3.7 bits/element. To the best of our knowledge, this is also the first implementation that has been successfully tested on an input of cardinality $10^{12}$. Source code: https://github.com/rizkg/BBHash
A Double Mutant of Sperm Whale Myoglobin Mimics the Structure and Function of Elephant Myoglobin (1995)

The functional, spectral, and structural properties of elephant myoglobin and the L29F/H64Q mutant of sperm whale myoglobin have been compared in detail by conventional kinetic techniques, infrared and resonance Raman spectroscopy, 1H NMR, and x-ray crystallography. There is a striking correspondence between the properties of the naturally occurring elephant protein and those of the sperm whale double mutant, both of which are quite distinct from those of native sperm whale myoglobin and the single H64Q mutant. These results and the recent crystal structure determination by Bisig et al. (Bisig, D. A., Di Iorio, E. E., Diederichs, K., Winterhalter, K. H., and Piontek, K. (1995) J. Biol. Chem. 270, 20754-20762) confirm that a Phe residue is present at position 29 (B10) in elephant myoglobin, and not a Leu residue as is reported in the published amino acid sequence. The single Gln64(E7) substitution lowers oxygen affinity approximately 5-fold and increases the rate of autooxidation 3-fold. These unfavorable effects are reversed by the Phe29(B10) replacement in both elephant myoglobin and the sperm whale double mutant. The latter, genetically engineered protein was originally constructed to be a blood substitute prototype with moderately low O2 affinity, large rate constants, and increased resistance to autooxidation. Thus, the same distal pocket combination that we designed rationally on the basis of proposed mechanisms for ligand binding and autooxidation is also found in nature.
An efficient and rapid protocol for plant nuclear DNA preparation suitable for next generation sequencing methods (2010)

The method presented here is fast and economical. The DNA obtained is of high quality, with a low level of cytoplasmic DNA contamination, and very efficient for the construction of sequencing libraries.
Mechanisms of Monocyte Recruitment in Vascular Repair After Injury (2005)

The inflammatory response to acute vessel wall injury has been increasingly recognized to play a decisive role in neointima formation. In particular, the exuberant infiltration with monocytes aggravates neointimal growth and can thereby promote restenosis. The adhesion of circulating monocytes to the site of mechanical injury represents the key event in monocyte recruitment, and this review highlights recent insights into the molecular mechanisms of monocyte adhesion throughout the course of neointimal growth. An acute and a chronic phase of monocyte recruitment after vascular injury can be discerned. The adhesion of platelets to the denuded subendothelial matrix is the hallmark of the acute phase providing an adhesive substrate for monocytes, whereas chronic monocyte recruitment is regulated by the interaction with neointimal smooth muscle cells and recovering endothelial cells. Clearly, the mechanisms of monocyte rolling and adhesion differ considerably between these diverse substrates. This review is particularly focused on the contribution of chemokines and adhesion molecules to monocyte recruitment to injured vessels according to the different stages of neointimal growth, and on closely related functions of the chemokine-like molecule macrophage migration inhibitory factor. Understanding the complex molecular interactions of the injured vessel wall with circulating monocytes may enable therapeutic targeting to prevent the development of restenosis.
Monolithic MEMS quadrupole mass spectrometers by deep silicon etching (2005)

A wafer-scale, batch fabrication process for constructing quadrupole mass spectrometers using microelectromechanical systems (MEMS) technology is described. The device is formed from two bonded silicon-on-insulator (BSOI) substrates, which are attached together to form a monolithic block. Deep etched features and springs formed in the outer silicon layers are used to locate cylindrical metal electrode rods, while similar features formed in the inner silicon layers are used to define integrated ion entrance and exit optics. The precision of the assembly is determined by lithography and deep etching, and by the mechanical definition of the bonded silicon layers. Mass filtering is demonstrated, with a mass range of /spl ap/ 400 a.m.u. and a mass resolution of 1 a.m.u. at 219 a.m.u., using quadrupoles with rods of 500 /spl mu/m diameter and 30 mm length, operating at 6 MHz RF frequency.
Automated Data Validation Testing Tool for Data Migration Quality Assurance (2014)

Abstract: Data migration has become one of the most demanding proposals for IT company managers. Even though these projects earn high business benefits, such as reduced costs, improved productivity, and data manageability, they likely to involve a high level of risk due to the huge volume and criticalness of moved data. In order to reduce risk and guarantee that the data has been migrated and transformed successfully, it is essential to employ a thorough Quality Assurance (QA) strategy in migration projects. Testing is a key phase of migration project for delivering a successful migrated data and addressing any issues prior and after the migration process. Manual testing for data validation process is time consuming and inaccurate; so automated data validation assure data quality with highly reduced time, cost and maintaining good data quality. The paper proposed automation of data migration validation testing process for quality assurance and risk control across industries.
Physiological Signals That Induce Flowering. (1993)

The timing of the transition from vegetative growth to flowering is of paramount importance in agriculture, horticulture, and plant breeding because flowering is the first step of sexual reproduction. Studies to understand how this transition is controlled have occupied countless physiologists during the past half century and have produced an almost unmanageably large amount of information (Bernier et al., 1981a; Halevy, 1985-1989; Bernier, 1988; Kinet, 1993). A majority of plants use environmental cues to regulate the transition to flowering because all individuals of a species must flower synchronously for successful outcrossing and because all species must complete their sexual reproduction under favorable externa1 conditions. Any environmental variables exhibiting regular seasonal changes are potential factors that control the transition to flowering. The major factors are photoperiod, temperature, and water availability. Plants that do not require a particular photoperiod or temperature to flower, i.e., the so-called “autonomous-flowering” plants, are usually sensitive to irradiance. The environmental factors are perceived by different parts of the plant. Photoperiod and irradiance are perceived mainly by mature leaves in intact plants. Temperature is perceived by all plant parts, although low temperature (vernalization) is often perceived mainly by the shoot apex. Water availability is perceived by the root system. There are strong interactions between these different factors, so that each factor can change the threshold value for the effectiveness of the others. Plants, as opportunists, will thus make use of a different critical factor in different environments. Melilotus officinalis, for example, is a biennial with a vernalization requirement in temperate zones and an annual long-day (LD) plant with no cold requirement in arctic regions. In photoperiodic species, such as the short-day (SD) plant Pharbitis nil and the LD plant Silene armeria, flowering in unfavorable photoperiods can be caused by changing temperature, irradiance, or nutrition or by removing the roots. Similarly, in some late-flowering mutants of Arabidopsis, vernalization and an increase in the proportion of far-red light in the light source can substitute for one another in promoting the transition to flowering (Martinez-Zapater and Somerville, 1990; Bagnall, 1992). Clearly, there are alternate pathways to flowering in most, if
Preparation and Properties of IPN Materials Containing Bisphenol A Acrylate and an Epoxide Hybrid Unit (2009)

Interpenetrating polymer networks (IPNs) were prepared by photo and thermal polymerizations of diacrylate, diepoxide and hybrid monomer mixtures, in which the functional groups in each monomer were linked by bisphenol A hard segment.Dynamic mechanical analysis, tensile tests, thermogravimetric analysis, hardness analysis and visible spectrometry were performed to evaluate the properties of the IPNs and their precursors.The IPNs obtained, containing a small amount of diepoxide, indicated the highest mechanical properties at a ratio of hybrid/diacrylate of around 1:2.This composition also agreed with the composition showing highest surface hardness and transparency.In addition, the influence of microwave irradiation on curing time was also studied.
Local structure study of Co-doped indium oxide and indium-tin oxide thin films using x-ray absorption spectroscopy (2009)

We have studied the local structural environment of Co in Co-doped indium oxide and indium-tin oxide films, obtained by magnetron sputtering. The $\text{Co}\text{ }K$-edge x-ray absorption spectroscopic studies have been correlated with the x-ray photoelectron spectroscopy, magnetic, and electrical transport measurements performed on the same films. Different contributions of oxidized $({\text{Co}}^{2+})$ and metallic $({\text{Co}}^{0})$ cobalt to the observed ferromagnetism in these films are found depending on the host semiconductor and Co content. Homogeneous substitution of Co atoms for the In sites is found in indium-tin oxide films with less than $7\text{ }\text{at}\text{.}\text{ }%$ of Co, obtained preferably by direct, not sequential, cosputtering. In indium oxide films with similar Co content, obtained by sequential deposition, substitution of Co for the In site is accompanied by a larger static local disorder. As the Co content increases, Co-metal clusters are formed.