gebhart/patrepeval huggingface dataset:
RB1CC1 Together with RB1 and p53 Predicts Long-Term Survival in Japanese Breast Cancer Patients (2010)

RB1-inducible coiled-coil 1 (RB1CC1) plays a significant role in the enhancement of the retinoblastoma tumor suppressor (RB1) pathway and is involved in breast cancer development. However, RB1CC1's role in clinical progression of breast cancer has not yet been evaluated, so, as a first step, it is necessary to establish its usefulness as a tool to evaluate breast cancer patients. In this report, we have analyzed the correlation between abnormalities in the RB1CC1 pathway and long-term prognosis, because disease-specific death in later periods (>5 years) of the disease is a serious problem in breast cancer. Breast cancer tissues from a large cohort in Japan were evaluated by conventional immunohistochemical methods for the presence of the molecules involved in the RB1CC1 pathway, including RB1CC1, RB1, p53, and other well-known prognostic markers for breast cancer, such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. The correlation between the immunohistochemical results and clinical outcomes of 323 breast cancer patients was analyzed using a Kaplan-Meier log-rank test and a multivariate Cox proportional hazards regression analysis. Absence of nuclear RB1CC1 expression was associated with the worst prognosis (Log-rank test, Chi-Square value = 17.462, p<0.0001). Dysfunction of either one of RB1CC1, RB1, or p53 was associated with the highest risk for cancer-specific death, especially related to survival lasting more than 5 years (multivariate Cox proportional hazard ratio = 3.951, 95% Confidence Interval =1.566-9.967, p = 0.0036). Our present data demonstrate that the combined evaluation of RB1CC1, RB1 and p53 by conventional immunohistochemical analysis provides an accurate prediction of the long-term prognoses of breast cancer patients, which can be carried out as a routine clinical examination.
Infantile Spasms Due to Unilateral Cerebral Infarcts (1987)

Infantile spasms are an age-specific seizure disorder that occur in infants with no known underlying disorder or prior neurologic insult (cryptogenic group) as well as in infants with a variety of genetic disorders or known prior neurologic insult (symptomatic group).1-8 The presence of infantile spasms is associated with a high incidence of developmental retardation (87%)3 even in previously normal infants.3,5-7 Although there are many contradictory studies, it is generally believed that the infants in the symptomatic group, especially those with abnormal findings on neurologic examination prior to the onset of the seizures, have a significantly higher incidence of mental retardation and epilepsy than the infants in the cryptogenic group.1-9
Heart Sound Measurement and Analysis System with Digital Stethoscope (2009)

This paper focuses on the heart sound measurement and analysis system for in-home use of heart condition monitoring. The heart sound acquiring system includes a traditional chest-piece, an earphone, a microphone and an IC recorder. The recorded data transmitted into a computer by USB interface are analyzed by the analytical model of single degree-offreedom(SDOF) for extracting cardiac sound characteristic waveform(CSCW). Furthermore, the 4 characteristic parameters [T1, T2, T11, T12] related to the first heart sound (SI) and the second heart sound (S2) are defined by the time intervals between the crossed points of the CSCW and the threshold value (THV) line in order to discriminate normal and abnormal heart sounds. Meanwhile, an easy understanding graphical representation for these parameters is considered, so that inexperienced users are able to monitor their heart condition easily. Finally, the case study on 40 normal and 20 abnormal heart sounds from 10 healthy volunteers and 5 patients with heart disorders is carried out, the higher discrimination performances are achieved 92.5%, 95% in accuracy, respectively. The usefulness and efficiency of this proposed system and the CSCW method are demonstrated.
Dietary Management of Feline Chronic Renal Failure: Where are We Now? In What Direction are We Headed? (2000)

Dietary modification is of primary importance in managing cats with chronic renal failure. Diets designed for cats with chronic renal failure are typically formulated to be pH neutral and contain reduced quantities of protein, phosphorus and sodium and an increased quantity of potassium. These changes in diet formulation are designed to ameliorate clinical signs of renal failure by adapting dietary intakes to meet the limited ability of failing kidneys to adapt to the normal range of dietary intakes. Important recent clinical trials support the therapeutic value of dietary therapy in cats with chronic renal failure.
The NFY Transcription Factor Mediates Induction of the von Willebrand Factor Promoter by Irradiation (2001)

Ionizing irradiation in patients is proposed to cause thrombus formation. An increase in von Willebrand factor secretion in response to irradiation is a major contributing factor to thrombus formation. We have previously reported that the increased VWF secretion in response to irradiation is mediated at the transcriptional level. The VWF core promoter fragment (sequences -90 to +22) was shown to contain the necessary cis-acting element(s) to mediate the irradiation response of the VWF gene. Here we report that a CCAAT element in the VWF promoter is the cis-acting element necessary for irradiation induction and that the NFY transcription factor interacts with this element. These analyses demonstrate that inhibition of NFY's interaction with the CCAAT element abolishes the irradiation induction of the VWF promoter. These results provide a novel role for NFY and add this factor to the small list of irradiation-responsive transcription factors. Coimmunoprecipitation experiments demonstrated that NFY is associated with the histone acetylase P/CAF in vivo and that irradiation resulted in an increased association of NFY with coactivator P/CAF. We propose that irradiation induction of the VWF promoter involves a mechanism resulting in increased recruitment of the coactivator P/CAF to the promoter via the NFY transcription factor.
Introduction: Destination or Journey (2007)

Dramatic Psychological Storytelling (DPS) presents a flexible seven-step model for insight and change. Anchored by Expressive Art and the action method, Psychotheatrics, DPS combines drama (expression through seven different Expressive Art types), with psychology (experiences of the individual and the collective), and storytelling (the content, the expression of an experience or situation). DPS creates a visual phenomenological, intersubjective framework as it depicts challenges, strategies and outcomes, whilst developing a dynamic storybook.KeywordsCollective SettingWitness ProcessPersonal TraumaNarrative FilmRational IntellectThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
On the Production and Use of the Optical-Contact Bond (1964)

The production and use of optical contact bonds including glass to glass and glass to fragile evaporated thin films is discussed. These bonds have freedom from chemical contamination and from uncertainty in mechanical location; they are permanent under normal conditions but may be dismantled for maintenance if necessary.
Two related but distinct forms of the Mr 36,000 tyrosine kinase substrate (calpactin) that interact with phospholipid and actin in a Ca2+-dependent manner. (1986)

A method was devised that allows the identification of proteins related to the Mr 36,000 tyrosine kinase substrate calpactin based on their ability to interact with actin and phospholipid in a calcium-dependent manner. Two distinct proteins, detected in human A431 cells and fibroblasts, were resolved by two-dimensional gel electrophoresis. One of these proteins (calpactin I) appears identical to the Mr 34,000-39,000 substrate of the pp60src tyrosine kinase and the second (calpactin II) reacts with antibodies to the Mr 35,000 substrate of the epidermal growth factor receptor. Both proteins interact with phospholipid and actin, are rather basic, and share structural and antigenic determinants. A major difference between the two proteins is noted in their state of association with the Mr 10,000 light chain; i.e., calpactin I is associated with the light chain while calpactin II is not.
Synthesis of lithium-manganese oxide spinel in hydrothermal conditions (2001)

Abstract Lithium-manganese oxide spinel LiMn2O4 was synthesized in hydrothermal conditions (400°C, 20 MPa) in the course of thermovaporous treatment mixtures of MnO2 and LiOH/or Li2CO3. The conditions of synthesis of the spinel as monophase product were determined. The obtained product has been characterized by means of various physical and chemical methods. The spinel has been used for manufacturing cathodes of rechargeable lithium cells. The cells discharged in the potential range 2.8-3.5 V. The specific capacity was 100-140mAh/g.
The use of prednisolone in the treatment of disseminated breast carcinoma (1958)

HE percentage of patients with dissemi-T nated breast carcinoma reported to have tumor regression from bilateral adrenalectomy varies from 15 per cent to 45 per cent.'. 4* 6* ' *
Improved digital backward propagation for the compensation of inter-channel nonlinear effects in polarization-multiplexed WDM systems (2011)

An improved split-step method (SSM) for digital backward propagation (DBP) applicable to wavelength-division multiplexed (WDM) transmission with polarization-division multiplexing (PDM) is presented. A coupled system of nonlinear partial differential equations, derived from the Manakov equations, is used for DBP. The above system enables the implementation of DBP on a channel-by-channel basis, where only the effect of phase-mismatched four-wave mixing (FWM) is neglected. A novel formulation of the SSM for PDM-WDM systems is presented where new terms are included in the nonlinear step to account for inter-polarization mixing effects. In addition, the effect of inter-channel walk-off is included. This substantially reduces the computational load compared to the conventional SSM.
<b>Imidazole-containing Polymers. Synthesis and Polymerization of the Monomer 4(5)-Vinylimidazole</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImidazole-containing Polymers. Synthesis and Polymerization of the Monomer 4(5)-VinylimidazoleC. G. Overberger and N. VorchheimerCite this: J. Am. Chem. Soc. 1963, 85, 7, 951–955Publication Date (Print):April 1, 1963Publication History Published online1 May 2002Published inissue 1 April 1963https://pubs.acs.org/doi/10.1021/ja00890a026https://doi.org/10.1021/ja00890a026research-articleACS PublicationsRequest reuse permissionsArticle Views1961Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fas Ligand-Mediated Lysis of Self Bystander Targets by Human Papillomavirus-Specific CD8<sup>+</sup>Cytotoxic T Lymphocytes (1998)

ABSTRACT Mouse cytotoxic T lymphocytes (CTL) reactive with a H-2D b -presented 9-mer peptide of the human papillomavirus type 16 protein E7 49-57 (RAHYNIVTF) were generated from the spleen cells of wild-type C57BL/6 (B6) or B6 perforin-deficient (B6.P 0 ) mice. CD8 + B6 CTL displayed peptide-specific perforin- and Fas-mediated lysis of E7-transfected mouse RMA lymphoma cells (RMA-E7), while CD8 + CTL from B6.P 0 mice lysed RMA-E7 cells via Fas ligand (FasL) exclusively. Rapid and efficient lysis of syngeneic bystander B6 blasts or RMA cells by either B6 or B6.P 0 Ag-activated CTL was mediated by a FasL-Fas mechanism. Fas-resistant bystanders were not lysed, nor were allogeneic Fas-sensitive C3H/HeJ ( H-2 k ) or BALB/c ( H-2 d ) bystander blasts. Interestingly, however, phorbol myristate acetate-ionomycin preactivation of B6.P 0 effectors enabled lysis of allogeneic H-2 k and H-2 d bystanders even in the absence of antigenic stimulation. Lysis of syngeneic bystander cells was always FasL-Fas dependent and required effector-bystander contact and, in particular, an interaction between CTL LFA-1 and bystander ICAM-1. Thus, in the context of major histocompatibility complex class I molecule-peptide ligation of the T-cell receptors of CD8 + CTL, neighboring bystander cells that are syngeneic and Fas sensitive and express the adhesion molecule ICAM-1 are potential targets of CTL attack.
Transdisciplinary science applied to the evaluation of treatments for tobacco use (2003)

Transdisciplinary research involves the integration of measures and methods across diverse response systems and levels of analysis, with that integration occurring via a synthesis of theories and models of different scientific disciplines. This paper first discusses the need for transdisciplinary research. The paper then articulates a model to guide the comprehensive evaluation of treatments for tobacco use and discusses how transdisciplinary research might be integrated into this treatment evaluation model. The potential benefits and costs of a transdisciplinary approach are discussed, along with selected research projects from the Transdisciplinary Tobacco Use Research Centers.
Long fiber Bragg grating sensor interrogation using discrete-time microwave photonic filtering techniques (2013)

A novel technique for interrogating photonic sensors based on long fiber Bragg gratings (FBGs) is presented and experimentally demonstrated, dedicated to detect the presence and the precise location of several spot events. The principle of operation is based on a technique used to analyze microwave photonics (MWP) filters. The long FBGs are used as quasi-distributed sensors. Several hot-spots can be detected along the FBG with a spatial accuracy under 0.5 mm using a modulator and a photo-detector (PD) with a modest bandwidth of less than 1 GHz. The proposed interrogation system is intrinsically robust against environmental changes.
Adaptive directional region growing segmentation of the hepatic vasculature (2008)

Accurate analysis of the hepatic vasculature is of great importance for many medical applications, such as liver surgical planning and diagnosis of tumors and/or vascular diseases. Vessel segmentation is a pivotal step for the morphological and topological analysis of the vascular systems. Physical imaging limitations together with the inherent geometrical complexity of the vessels make the problem challenging. In this paper, we propose a series of methods and techniques that separate and segment the portal vein and the hepatic vein from CT images, and extract the centerlines of both vessel trees. We compare the results obtained with our iterative segmentation-and-reconnection approach with those obtained with a traditional region growing method, and we show that our results are substantially better.
Domain Adaptation for Machine Translation by Mining Unseen Words (2011)

We show that unseen words account for a large part of the translation error when moving to new domains. Using an extension of a recent approach to mining translations from comparable corpora (Haghighi et al., 2008), we are able to find translations for otherwise OOV terms. We show several approaches to integrating such translations into a phrasebased translation system, yielding consistent improvements in translations quality (between 0.5 and 1.5 Bleu points) on four domains and two language pairs. 1
Functional elements associated with hepatic regeneration in living donors after right hepatic lobectomy (2012)

We quantified the rates of hepatic regeneration and functional recovery for 6 months after right hepatic lobectomy in living donors for liver transplantation. Twelve donors were studied pre-donation (baseline); 8 were retested at a mean ± SD of 11±3 days after donation (T1), 10 were retested at a mean of 91±9 days after donation (T2), and 10 were retested at a mean of 185±17 days after donation (T3). Liver and spleen volumes were measured with computed tomography (CT) and single-photon emission computed tomography (SPECT). Hepatic metabolism was assessed with caffeine and erythromycin, and hepatic blood flow (HBF) was assessed with cholates, galactose, and the perfused hepatic mass (PHM) by SPECT. The regeneration rates (mL kg(-1) of body weight day(-1)) by CT were 0.60±0.22 mL from the baseline to T1, 0.05±0.02 mL from T1 to T2, and 0.01±0.01 from T2 to T3; by SPECT they were 0.54±0.20, 0.04±0.01, and 0.01±0.02, respectively. At T3, the liver volumes were 84%±7% of the baseline according to CT and 92%±13% of the baseline according to SPECT. Changes in the hepatic metabolism did not achieve statistical significance. At T1, the unadjusted clearance ratios with respect to the baseline were 0.75±0.07 for intravenous cholate (P<0.001), 0.88±0.15 for galactose (P=0.07), 0.84±0.08 for PHM (P=0.002), and 0.83±0.19 for the estimated HBF (P=0.06). At T1, these ratios adjusted per liter of liver were up to 50% greater than the baseline values, suggesting recruitment of HBF by the regenerating liver. Increased cholate shunt, increased spleen volume, and decreased platelet count, were consistent with an altered portal circulation. In conclusion, initial hepatic regeneration is rapid, accounts for nearly two-thirds of total regeneration, and is associated with increases in HBF and cholate uptake. Right lobe donation alters the portal circulation of living donors, but the long-term clinical consequences, if there are any, are unknown.
Evolutionary relationships among Aspergillus oryzae and related species based on the sequences of 18S rRNA genes and internal transcribed spacers. (1998)

The mold Aspergillus oryzae is widely used in Japan as a koji mold for the fermentation of sake, miso, and soy sauce and belongs to the genus Aspergillus section Flavi Aspergillus sojae is also used as a koji mold for soy sauce fermentation. On the other hand, A. flavus, A. parasiticus, and A. nomius are known to commonly infect cereal grains and peanuts; it is also kwown that many of their isolates produce aflatoxins, the carcinogenic secondary metabolites. Many taxonomical studies on these species have been carried out (Gams et al.,
Regulation of epithelial chloride channels by protein phosphatase (1991)

A combination of planar bilayer and patch-clamp techniques was used to determine whether apical membrane Cl- channels of shark (Squalus acanthias) rectal gland (SRG) were regulated by a phosphorylating and dephosphorylating cycle. In channel reconstitution studies, apical membrane vesicles of SRG were purified, incubated in ATP-Mg2+ and the presence or absence (control) of catalytic subunit of adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase (cAMP-PK) and incorporated into planar lipid bilayers. In the presence of cAMP-PK, two distinct Cl- channels were found when imposing either 450/50 or 300/50 mM KCl (cis/trans) gradients. The most frequently observed channels (G beta 1) were open greater than 80% at all potentials between -60 and +20 mV (trans ground) and were inactivated by alkaline phosphatase added to the cis chamber. The single-channel conductance of G beta 1 was 42 pS between -60 and +20 mV with a 300/50 mM KCl gradient. The second channel (G beta 2) was always observed in pairs of 62-pS subchannels and was not affected by alkaline phosphatase, but the open probability increased with depolarizing potentials. G beta 2 was observed once, but G beta 1 was never observed in the absence of cAMP-PK. In parallel patch-clamp studies of the apical membrane of cultured SRG, a 50-pS channel similar to G beta 1 was noted after incubating cells with either forskolin, an activator of adenylate cyclase, or okadaic acid, an inhibitor of protein phosphatases 1 and 2A. It is concluded that G beta 1 of SRG can be studied in both patch-clamp and bilayer preparations and that G beta 1 is regulated by reversible phosphorylation by cAMP-PK and dephosphorylation by a protein phosphatase.
The flanking amino acids of the human follitropin beta-subunit 33-53 region are involved in assembly of the follitropin heterodimer (1993)

Previous analyses of the topology of human follitropin (hFSH) with monoclonal antibodies and antipeptide antibodies have led to a current operating hypothesis that some amino acids within the hFSH beta 33-53 region are surface oriented, and others participate in subunit contact. Protein structural analysis predicts beta-turns within this region, and the immunochemical studies indicate that the ends may be involved in subunit contact. In this study, hFSH beta was mutagenized to change 34TRDL37 to 34AAAA37 or 48QKTCT52 to 48AAACA52, allowing us to study the ends of the hFSH beta 33-53 sequence contiguous with the hFSH beta sequence. Wild-type and mutant cDNAs were coexpressed with alpha-subunit cDNA in CHOPro-5 cells. Wild-type hFSH was secreted from cells cotransfected with wild-type hFSH alpha and hFSH beta cDNAs, as expected. However, heterodimeric hFSH was minimally detected in the medium from cells transfected with the 34TRDL37 mutant and was not detected in the case of the 48QKTCT52 mutant. Analysis of cell lysates (intracellular FSH) by immunoprecipitation and polyacrylamide gel electrophoresis showed that wild-type and mutant beta-subunits were indistinguishable and recoverable intact from each cell line. Additionally, analysis of lysates with a conformation-specific monoclonal antibody 3G3 revealed that similar levels of properly folded beta-subunit were produced in cells expressing wild-type or either mutated beta-subunit. These data indicate that the flanking amino acids of the hFSH beta 33-53 region, in particular 48QKTCT52, are critical for assembly of hFSH heterodimer.
The Fitting of Straight Lines when Both Variables are Subject to Error (1959)

Abstract Consider the situation where X and Y are related by Y = α + βX, where α and β are unknown and where we observe X and Y with error, i.e., we observe x = X + u and y = Y + v. Assume that Eu = Ev = 0 and that the errors (u and v) are uncorrelated with the true values (X and F). We survey and comment on the solutions to the problem of obtaining consistent estimates of α and β from a sample of (x, y)'s, (1) when one makes various assumptions about properties of the errors and the true values other than those mentioned above, and (2) when one has various kinds of “additional information” which aids in constructing these consistent estimates. The problems of obtaining confidence intervals for β and of testing hypotheses about β are not discussed, though approximate variances of some of the estimates of β are given.