gebhart/patrepeval huggingface dataset:
Brief advice to stop drinking for adults with high GGT levels reduced alcohol consumption at 1 year (1992)

TherapeuticsJanuary 1, 1992Brief advice to stop drinking for adults with high GGT levels reduced alcohol consumption at 1 yearWilliam D. Clark, MDWilliam D. Clark, MDAddiction Resource Center, Bath, Maine, USA (W.D.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-1992-116-1-006 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinkedInRedditEmail Source CitationNilssen O. The Tromsø study: identification of and a controlled intervention on a population of early-stage risk drinkers. Prev Med. 1991 May-Jun;20:518-28.References1 Barbor T, Grant M. From clinical research to secondary prevention. Alcohol Health Res World. 1989;13:371-4. Google Scholar2 Wallace P, Cutler S, Haines A. Randomized controlled trial of general practitioner intervention in patients with excessive alcohol consumption. BMJ. 1988;297:663-9. Google Scholar3 Graham A. Screening for alcoholism by life-style risk assessment in a community hospital. Arch Intern Med. 1991;151:958-64. Google Scholar Author, Article, and Disclosure InformationAffiliations: Addiction Resource Center, Bath, Maine, USA (W.D.C.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails January 1, 1992Volume 116, Issue 1Page: 6KeywordsAlcohol consumptionAlcoholismAlcoholsAnticonvulsantsBeveragesBloodMotivationPrevention, policy, and public healthQuestionnairesWine ePublished: 9 March 2020 Issue Published: January 1, 1992 Copyright & PermissionsCopyright © 1992 by American College of Physicians. All Rights Reserved.Loading ...
Fabrication and Investigation of Drawn Fiber Tapers with Spherical Microlenses (1985)

Methodes fabrication simples et reproductibles de coupleurs constitues d'une extremite etiree conique d'une fibre optique avec une microlentille spherique fusionnee. On obtient des rendements de couplage avec un laser semiconducteur de plus de 55%
Highly sensitive enzyme immunoassay for beta-nerve growth factor (NGF): a tool for measurement of NGF level in rat serum. (1990)

A sensitive two-site enzyme immunoassay (EIA) system was established for mouse beta nerve growth factor (NGF) isolated from mouse submaxillary gland. Our EIA system is based on the sandwiching of antigen between anti-mouse beta NGF antibody IgG coated on a polystyrene plate and biotinylated anti-mouse beta NGF antibody IgG. The bound antibody complex was quantified with streptavidin linked-beta-D-galactosidase (beta-D-galactosidase, EC 3.2.1.23). With this system NGF concentrations as low as 0.02 pg/well (corresponding to 8 x 10(-19) mol) could be measured reproducibly. The sensitivity of this EIA system permitted the quantification of endogenous immunoreactive beta NGF in rat serum. The mean level in serum of male rats (153.2 pg/ml) was found to be almost the same as that of female rats (127.6 pg/ml).
Effect of Temperature on the Low-velocity Impact Behavior of Composite Sandwich Panels (2005)

Composite sandwich panels constructed from glass-fiber-reinforced facesheets surrounding both foam-filled and nonfilled honeycomb cores are impacted using a drop-weight impactor at three energy levels and three temperatures. The effects of core material, temperature, and impact velocity on the absorbed energy, peak impact force, and damage mechanisms were studied. The foam-filled samples were subsequently subjected to four-point bend tests to investigate the effect of impact velocity and temperature on the damage tolerance and residual strength of the composites. It was found that the temperature can have a significant effect on the energy absorbed and maximum force encountered during impact, although the effect of the impact temperature on the residual bending stiffness and strength of the composites was mixed. In addition, the nature of the core material greatly influenced the damage mechanisms and impact force transfer in the honeycomb sandwich composites.
Inhibiting Effect of Surfactants and Heavy Metal Ions on the Denitrification Process (2005)

The effect of selected surfactants and heavy metal ions on the kinetics of the process of denitrification taking place with the involvement of Bacillus licheniformis bacteria has been studied. The limiting concentrations of the compounds studied and the coefficients of inhibition have been determined. A kinetic model of denitrification was carried out in a lactate medium with the addition of a quaternary ammonium salt APDA has been proposed. The process has been shown to occur according to the autocatalytic model of the second order with respect to nitrates (V) and proteins and first order with respect to nitrates (III) for the subseguent irreversible reaction.
Calcium Signaling Mediated by P2Y Receptors in Mouse Taste Cells (2003)

Evidence implicates a number of neuroactive substances and their receptors in mediating complex cell-to-cell communications in the taste bud. Recently, we found that ATP, a ubiquitous neurotransmitter/neuromodulator, mobilizes intracellular Ca2+ in taste cells by activating P2Y receptors. Here, P2Y receptor-cellular response coupling was characterized in detail using single cell ratio photometry and the inhibitory analysis. The sequence of underlying events was shown to include ATP-dependent activation of PLC, IP3 production, and IP3 receptor-mediated Ca2+ release followed by Ca2+ influx. Data obtained favor SOC channels rather than receptor-operated channels as a pathway for Ca2+ influx that accompanies Ca2+ release. Intracellular Ca2+ mobilized by ATP is apparently extruded by the plasma membrane Ca2+-ATPase, while a contribution of the Na+/Ca2+ exchange and other mechanisms of Ca2+ clearance is negligible. Cyclic AMP-dependent phosphorylation is likely to control a gain of the phosphoinositide cascade involved in ATP transduction. ATP-responsive taste cells are abundant in circumvallate, foliate, and fungiform papillae. Taken together, our observations point to a putative role for ATP as a neurotransmitter operative in the taste bud.
Role of Text Mining in Information Extraction and Information Management (2005)

This article deals with the definitions of text mining and the need for it. The components of text mining are explained as information retrieval, information processing and information integration. The powerful technique that helps to identify the relevant S&T literature is enumerated with five primary conditions for information extraction. The three stages of Knowledge Discovery in Data and Data Mining (KDD) process is given with the applications of text mining. Applications of text mining vary from Information retrieval, bioinformatics, patent analysis, sorting gene expression, mining hospital records and multilingual approach to cross-lingual text retrieval (CLTR), analysis of e-mails, etc. Also explained the current status like new methods for text analysis in biology and medicine, the software viz. TextAnalyst meant for semantic analysis, navigation and search of unstructured texts with the 'Linking Information for Novel Discovery and Insight' (LINDI) project at Berkeley for helping the researchers. The internationally leading consortium for text mining viz. National Centre for Text Mining at UMIST with four UK partner institutions has been given. The limitations and benefits of text mining are given and concluded that library and information science professionals should implement the same for providing the relevant information from the vast amount of information. http://dx.doi.org/10.14429/dbit.25.4.3663
Exchange rates and water content of a cation exchange membrane in aprotic solvents (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExchange rates and water content of a cation exchange membrane in aprotic solventsMaria. Lopez, Brian. Kipling, and Howard L. YeagerCite this: Anal. Chem. 1976, 48, 8, 1120–1122Publication Date (Print):July 1, 1976Publication History Published online1 May 2002Published inissue 1 July 1976https://pubs.acs.org/doi/10.1021/ac50002a014https://doi.org/10.1021/ac50002a014research-articleACS PublicationsRequest reuse permissionsArticle Views298Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improving Web Search Using Contextual Retrieval (2009)

Contextual retrieval is a critical technique for todaypsilas search engines in terms of facilitating queries and returning relevant information. This paper reports on the development and evaluation of a system designed to tackle some of the challenges associated with contextual information retrieval from the World Wide Web (WWW). The developed system has been designed with a view to capturing both implicit and explicit user data which is used to develop a personal contextual profile. Such profiles can be shared across multiple users to create a shared contextual knowledge base. These are used to refine search queries and improve both the search results for a user as well as their search experience. An empirical study has been undertaken to evaluate the system against a number of hypotheses. In this paper, results related to one are presented that support the claim that users can find information more readily using the contextual search system.
The influence of patient centering on CT dose and image noise (2007)

Although x-ray intensity shaping filters (bowtie filters) have been used since the introduction of some of the earliest CT scanner models, the clinical implications on dose and noise are not well understood. To achieve the intended dose and noise advantage requires the patient to be centered in the scan field of view. In this study we explore the implications of patient centering in clinical practice. We scanned various size and shape phantoms on a GE LightSpeed VCT scanner using each available source filter with the phantom centers positioned at 0, 3, and 6 cm below the center of rotation (isocenter). Surface doses were measured along with image noise over a large image region. Regression models of surface dose and noise were generated as a function of phantom size and centering error. Methods were also developed to determine the amount of miscentering using a scout scan projection radiograph (SPR). These models were then used to retrospectively evaluate 273 adult body patients for clinical implications. When miscentered by 3 and 6 cm, the surface dose on a 32 cm CTDI phantom increased by 18% and 41% while image noise also increased by 6% and 22%. The retrospective analysis of adult body scout SPR scans shows that 46% of patients were miscentered in elevation by 20-60 mm with a mean position 23 mm below the center of rotation (isocenter). The analysis indicated a surface dose penalty of up to 140% with a mean dose penalty of 33% assuming that tube current is increased to compensate for the increased noise due to miscentering. Clinical image quality and dose efficiency can be improved on scanners with bowtie filters if care is exercised when positioning patients. Automatically providing patient specific centering and scan parameter selection information can help the technologist improve workflow, achieve more consistent image quality and reduce patient dose.
The interaction of tube waves with borehole fractures; Part II, Analytical models (1998)

Abstract We develop a series of analytical models that can be used to interpret Stoneley-wave reflections from fractures intersecting a borehole, thus facilitating the determination of effective fracture apertures from logs. The first model considers the combined effects of borehole enlargements (e.g., washouts) and fractures on the reflection coefficient of Stoneley waves. The result is expressed in terms of the washout volume, which can be obtained from a caliper log, as well as the fracture width. The predictions of this model are in excellent agreement with finite-difference calculations. Next we develop an analytical elastic model that generalizes the rigid formation model. It also agrees with finite-difference calculations. Finally, we establish the equivalence between a closely spaced multiple fracture and a permeable medium. In all the examples, the generalization of the result for the single fracture in a rigid formation can be accomplished with standard logging measurements.
Photodynamic Therapy of Subfoveal Choroidal Neovascularization in Age-related Macular Degeneration With Verteporfin (1999)

The visual acuity benefits of verteporfin therapy for AMD patients with predominantly classic CNV subfoveal lesions are safely sustained for 2 years, providing more compelling evidence to use verteporfin therapy for these cases. For AMD patients with subfoveal lesions that are minimally classic, there is insufficient evidence to warrant routine use of verteporfin therapy.
Nocturnal asthma monitoring by chest wall electromyography (2011)

Nocturnal respiratory effort is increased in those with asthma and neural respiratory drive is more variable in patients with poorly controlled asthma. Changes in the EMG(para) inversely reflect changes in pulmonary function tests. Measuring the EMG(para) offers a method to monitor asthma breath-by-breath while subjects are asleep, which could be adapted for home use.
FDTD analysis of a metal-strip-loaded dielectric leaky-wave antenna (1997)

The finite-difference time-domain (FDTD) method is used to analyze a dielectric leaky-wave antenna comprising metal strips etched on a rectangular dielectric rod. The radiation patterns of the leaky-wave antenna with and without the transition are determined by using FDTD. The effects of the launching discontinuity on the performance of the antenna are discussed. In addition, the application of the perfectly matched layer (PML) technique to the three-dimensional (3-D) dielectric waveguide and its performance, compared to those of the Mur's (1981) first-order and super-absorbing Mur's first-order absorbing boundary conditions (ABCs) are described. In addition, the effects caused by perturbation on the wave propagation characteristics of dielectric waveguide are also discussed. The FDTD results are verified by a W-band experiment and found to be in good agreement.
A progestagen-dependent endometrial protein in human amniotic fluid (1980)

A protein was detected in human amniotic fluid that had properties identical to those of the progestagen-dependent endometrial protein. The concentration of the amniotic fluid protein was maximal during Weeks 15-18 of pregnancy and then declined rapidly. The protein was not detected in immature and mature placentae, ovary, Fallopian tube, myometrium and cervix. We conclude that a specific protein synthesized by the human uterine decidua is transported to the amniotic sac.
Diagnosis and Treatment of Cluster Headache (2006)

Cluster headache is an uncommon yet distinctive neurovascular syndrome occurring in either episodic or chronic patterns. The most unique feature of cluster headache is the unmistakable circadian and circannual periodicity. The attacks are stereotypical, that is, of extreme intensity, of short duration, occurring unilaterally, and associated with robust signs and symptoms of autonomic dysfunction. Unlike migraine, during an attack the patient with cluster headache often paces about. Attacks frequently occur at night, awakening the patient from sleep. Although the pathophysiology of cluster headache remains to be fully elucidated, several seminal observations have recently been made. The medical treatment of cluster headache includes acute, transitional, and maintenance prophylaxis. Agents used for acute therapy include inhalation of oxygen and triptans, such as sumatriptan, and dihydroergotamine. Transitional prophylaxis refers to the short-term use of fast-acting agents. This typically involves either corticosteroids or ergotamine derivatives. The mainstay of prophylactic therapy is verapamil. Lithium, divalproex sodium, or topiramate may also be useful. As the sophistication of functional neuroimaging increases, so too will our ability to better understand the anatomic and metabolic perturbations that underlie cluster headache.
The final deprotection step in oligonucleotide synthesis is reduced to a mild and rapid ammonia treatment by using labile base-protecting groups (1987)

Phenoxyacetyl (pac) and methoxyacetyl (mac) for adenine and guanine, isobutyryl for cytosine, were successfully applied as amino protecting groups both in phosphotriester and phosphoramidite approaches. As shown by N.M.R. and H.P.L.C. analysis, they are completely deblocked in less than four hours in 29% ammonia at room temperature allowing the preparation of modified DNA containing alkali labile bases such as saturated pyrimidines. The stability of N6-phenoxyacetyl-deoxyadenosine versus depurination in acidic conditions used in the detritylation step was favorably compared with that of the classic N6-benzoyl protected adenine.
Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in <i>in vitro</i> and <i>in vivo</i> models of Alzheimer's disease (2015)

Objectives: The pathogenesis of Alzheimer's disease (AD) is strongly correlated with the aggregation and deposition of the amyloid beta (Aβ1–42) peptide in fibrillar form, and many studies have shown that plant-derived polyphenols are capable of attenuating AD progression in various disease models. In this study, we set out to correlate the effects of anthocyanoside extracts (Vaccinium myrtillus anthocyanoside (VMA)) obtained from bilberry on the in vitro progression of Aβ fibril formation with the in vivo effects of this compound on AD pathogenesis.Methods: Thioflavin T fluorescence assays and atomic force microscopy were used to monitor Aβ amyloid formation in in vitro assays. Effects of Aβ amyloids on cellular viability were assayed using cultured Neuro2a cells. Cognitive effects were probed using mice that simultaneously expressed mutant human Aβ precursor and mutant presenilin-2.Results: Addition of VMA inhibited the in vitro formation of Aβ peptide fibrils and also reduced the toxicity of these aggregates toward Neuro2a cells. A diet containing 1% VMA prevented the cognitive degeneration in AD mice. Curiously, this diet-derived retention of cognitive ability was not accompanied by a reduction in aggregate deposition in brains; rather, an increase in insoluble deposits was observed compared with mice raised on a control diet.Discussion: The paradoxical increase in insoluble deposits caused by VMA suggests that these polyphenols divert Aβ aggregation to an alternate, non-toxic form. This finding underscores the complex effects that polyphenol compounds may exert on amyloid deposition in vivo.
Hardware-sensitive optimization for intensity modulated radiotherapy (2000)

The multileaf collimator (MLC) hardware constraints are usually neglected in the process of intensity-modulated beam optimization. Consequently, it is not always possible to deliver planned beam modulation using dynamic MLC. Beam optimization is significantly diminished if the results must be approximated due to limitations imposed by the delivery device. To overcome this problem, an inverse beam optimization method which incorporates the hardware constraints has been developed. The hardware constraints, including the leaf velocity, the dose rate and the minimum required gap between opposing and adjacent leaves, were considered. An iterative search for feasible modulation was conducted alternately in the dosimetric space and the MLC position-time space. The optimization algorithm was designed for a unidirectional leaf trajectory and a constant dose rate. A scheme to reduce tongue-and-groove underdosage during optimization was also implemented. Comparisons were made between the solutions produced by this method and conventional optimization disregarding the hardware restrictions. The beam profiles generated by the conventional method were modified to satisfy the hardware specifications. The results indicate that inclusion of MLC constraints during optimization can improve the degree of conformity that is deliverable.
Embedded Driver-Assistance System Using Multiple Sensors for Safe Overtaking Maneuver (2012)

Advanced driver-assistance systems have recently become one of the most active topics related to intelligent vehicles. Such assistance facilitates vehicular operation by allowing drivers increased control and an enhanced driving experience, and it even comes in the form of automated assistance for autonomous vehicle operation. This paper presents a driver-assistance system that uses a low-cost embedded digital signal processor, with the overall system installed in a commercial vehicle. Based on driving information supplied by multiple sensors, such as a real-time vision system, a vehicle-to-vehicle communication system, and in-vehicle sensors, the proposed system can facilitate decision making and the performing of driving tasks while executing overtaking maneuvers. This paper developed a data fusion stage based on a collision warning algorithm in which the overtaken vehicle and other vehicles in the neighboring lane are accounted for to avoid collisions. The system employs fuzzy control in the steering and speed automation to emulate the driving tasks performed by humans. The applicability of the proposed system was examined in a real-road environment, and a set of experimental results demonstrate the feasibility of using the involved coordination strategies while conducting various driving maneuvers.
A propos de la compétence pour les litiges intéressant les magistrats ou les auxiliaires de justice : procédures collectives et surprises de la cassation sans renvoi. (2009)

International audience
IFN Unresponsiveness in LNCaP Cells Due to the Lack of <i>JAK1</i> Gene Expression (2005)

We reported previously that 23% of human lung adenocarcinoma cell lines were unresponsive to IFN-gamma. To extend this finding to cancer cells derived from distinct tissues of origin, we assessed IFN-gamma receptor signaling in the LNCaP human prostate adenocarcinoma cell line, which in previous experiments by others failed to induce a range of IFN-dependent biological responses. In this report, we show that LNCaP cells fail to respond to either IFN-gamma or IFN-alpha because of an impairment in the proximal signaling events downstream of both IFN-gamma and IFN-alpha/beta receptors that lead to the activation of STAT1. Furthermore, we show that LNCaP insensitivity to the IFNs is a result of the absence of expression of the JAK1 kinase, an obligate component shared by both IFN-gamma and IFN-alpha/beta receptors. JAK1 was undetectable in LNCaP cells at both protein and message levels. Treatment of LNCaP cells with a combination of inhibitors of DNA methyltransferases and histone deacetylases induced expression of JAK1 message. These results identify the molecular basis for IFN insensitivity in the LNCaP cell line and suggest that epigenetic silencing of key immunologic signaling components may be one mechanism by which tumor cells evade immune detection and elimination.