gebhart/patrepeval huggingface dataset:
A quantitative performance evaluation of SCI memory hierarchies (1994)

The Scalable Coherent Interface (SCI) is an IEEE standard that defines a hardware platform for scalable shared-memory multiprocessors. SCI consists of three parts. The first is a set of physical interfaces that defines board sizes, wiring and network clock rates. The second is a communication protocol based on unidirectional point to point links. The third defines a cache coherence protocol based on a full directory that is distributed amongst the cache and memory modules. The cache controllers keep track of the copies of a given datum by maintaining them in a doubly linked list. SCI can scale up to 65520 nodes. This dissertation contains a quantitative performance evaluation of an SCIconnected multiprocessor that assesses both the communication and cache coherence subsystems. The simulator is driven by reference streams generated as a by-product of the execution of “real” programs. The workload consists of three programs from the SPLASH suite and three parallel loops. The simplest topology supported by SCI is the ring. It was found that, for the hardware and software simulated, the largest efficient ring size is between eight and sixteen nodes and that raw network bandwidth seen by processing elements is limited at about 80Mbytes/s. This is because the network saturates when link traffic reaches 600–700Mbytes/s. These levels of link traffic only occur for two poorly designed programs. The other four programs generate low traffic and their execution speed is not limited by interconnect nor cache coherence protocol. An analytical model of the multiprocessor is used to assess the cost of some frequently occurring cache coherence protocol operations. In order to build large systems, networks more sophisticated than rings must be used. The performance of SCI meshes and cubes is evaluated for systems of up to 64 nodes. As with rings, processor throughput is also limited by link traffic for the same two poorly designed programs. Cubes are 10–15% faster than meshes for programs that generate high levels of network traffic. Otherwise, the differences are negligible. No significant relationship between cache size and network dimensionality was found.
Engineered Recombinant Peanut Protein and Heat-Killed <i>Listeria monocytogenes</i> Coadministration Protects Against Peanut-Induced Anaphylaxis in a Murine Model (2003)

Peanut allergy (PNA) is the major cause of fatal and near-fatal anaphylactic reactions to foods. Traditional immunotherapy using peanut (PN) protein is not an option for PNA therapy because of the high incidence of adverse reactions. We investigated the effects of s.c. injections of engineered (modified) recombinant PN proteins and heat-killed Listeria monocytogenes (HKLM) as an adjuvant on anaphylactic reactions in a mouse model of PN allergy. PN-allergic C3H/HeJ mice were treated s.c. with a mixture of the three major PN allergens and HKLM (modified (m)Ara h 1-3 plus HKLM). The effects on anaphylactic reactions following PN challenge and the association with Ab levels and cytokine profiles were determined. Although all mice in the sham-treated groups exhibited anaphylactic symptoms with a median symptom score of 3, only 31% of mice in the mAra h 1-3 plus HKLM group developed mild anaphylaxis, with a low median symptom score of 0.5. Alterations in core body temperature, bronchial constriction, plasma histamine, and PN-specific IgE levels were all significantly reduced. This protective effect was markedly more potent than in the mAra h 1-3 protein alone-treated group. HKLM alone did not have any protective effect. Reduced IL-5 and IL-13, and increased IFN-gamma levels were observed only in splenocytes cultures from mAra h 1-3 plus HKLM-treated mice. These results show that immunotherapy with modified PN proteins and HKLM is effective for treating PN allergy in this model, and may be a potential approach for treating PNA.
가상 커뮤니티 유형별 커뮤니티 충성도에 미치는 영향 연구 (2006)

최근 공통된 관심사로 형성된 가상 커뮤니티의 영향력은 단순한 정보교류나 친목도모의 차원을 넘어 기업의 수익창출에 거대한 영향력을 발휘하고 있으며 중요한 공간으로의 영역을 형성하게 되었다. 이에 많은 문헌연구를 통하여 가상 커뮤니티에 대한 영향력이 입증되면서 수많은 기업들은 커뮤니티의 중요성에 대해 주목하기 시작하였다....
Tamoxifen and CYP2D6: A Contradiction of Data (2012)

Tamoxifen is an effective antiestrogen used in the treatment of hormone receptor-positive breast cancer. Bioconversion of tamoxifen to endoxifen, its most abundant active metabolite, is primarily dependent on the activity of cytochrome P450 2D6 (CYP2D6), which is highly polymorphic. Over 20 published studies have reported on the potential association between CYP2D6 polymorphism and tamoxifen treatment outcome, with highly inconsistent results. The purpose of this review is to explore differences among 17 independent studies to identify factors that may have contributed to the discrepant findings. This report discusses six putative factors that are grouped into two categories: (a) clinical management criteria: hormone receptor classification, menopausal status, and tamoxifen combination therapy; (b) pharmacologic criteria: genotyping comprehensiveness, CYP2D6 inhibitor coadministration, and tamoxifen adherence. Comparison of these factors between the positive and negative studies suggests that tamoxifen combination therapy, genotyping comprehensiveness, and CYP2D6 inhibitor coadministration may account for some of the contradictory results. Future association studies on the link between CYP2D6 genotype and tamoxifen treatment efficacy should account for combination therapy and CYP2D6 inhibition, and interrogate as many CYP2D6 alleles as possible.
Design of potent oxytocin antagonists featuring D-tryptophan at position 2 (1991)

We prepared nine analogues (1-9) of MCPA-D-Phe-Phe-Ile-Asn-Cys-Pro-Arg-Gly-NH2, [MCPA1, D-Phe2, Phe3, Ile4, Arg8]oxytocin (MCPA = beta-mercapto-beta,beta-pentamethylenepropionic acid), a potent antagonist of the rat uterotonic action of oxytocin (OT). We replaced D-Phe with D-Trp and made [MCPA1,D-Trp2,Phe3,Ile4,Arg8]OT (1), which had OT pA2 of 7.51, somewhat higher than that of the D-Phe2 antagonist which has OT pA2 = 7.35 in our rat uterotonic assay. Both compounds are equipotent as antagonists of [Arg8]vasopressin in the rat antidiuretic assay, with pA2 = 8.1. Other substitutions gave [MCPA1,D-Trp2,4-Cl-Phe3,Ile4,Arg8]OT, (2), OT pA2 7.44; [MCPA1,D-Trp2,Phe3,Ile4,3,4-dehydro-Pro7,Arg8]OT (3), OT pA2 = 7.42; [MCPA1,D-Trp2,Phe3,Arg8]OT (4), OT pA2 = 7.58; [MCPA1,D-Trp2,Phe3,Arg8,Gly9-NHEt]OT (5), OT pA2 = 7.49; [MCPA1,D-Trp2,Ile4,Arg8]OT (6), OT pA2 = 7.46; [MCPA1,D-Trp2,Val4,Arg8]OT (7), OT pA2 = 7.58; [MCPA1,D-Trp2,Thr4,Arg8]OT (8), OT pA2 = 7.48; and finally, [MCPA1,D-Trp2,Arg8]OT (9), which was a more potent and more selective OT antagonist, with OT pA2 = 7.77 in the uterotonic assay and ADH pA2 less than 5.9 in the antidiuretic assay and hence is an important lead for the design of OT antagonists.
On random rotations diversity and minimum MSE decoding of lattices (2000)

We establish a simple relation between high-diversity multidimensional rotations obtained from totally complex cyclotomic fields and the discrete Fourier transform. The diversity distribution of an Hadamard-like random rotation is derived analytically. It is shown that a random multidimensional rotation exhibits an excellent diversity distribution and can be combined to quadrature amplitude modulation (QAM) constellations to combat channel fading. We also describe a mean-square error (MSE) universal lattice decoder suitable for large dimensions up to 1024. The MSE criterion treats the lattice structure as intersymbol interference. The universal decoder is applied to both Gaussian and Rayleigh fading channels to decode dense lattice sphere packings and rotated cubic constellations, respectively.
High‐Speed Near Infrared Optical Receivers Based on Ge Waveguide Photodetectors Integrated in a CMOS Process (2008)

We discuss our approach to monolithic intergration of Ge photodectors with CMOS electronics for high‐speed optical transceivers. Receivers based on Ge waveguide photodetectors achieve a sensitivity of −14.2 dBm (10 −12 bit error rate (BER)) at 10 Gbps and 1550 nm.
Improved weight management using genetic information to personalize a calorie controlled diet (2007)

Addition of nutrigenetically tailored diets resulted in better compliance, longer-term BMI reduction and improvements in blood glucose levels.
Specificity in the Factor VIII Response to Vasopressin Infusion in Man (1979)

Structural requirements of the systemic factor VIII response to intravenous vasopressin in man has been investigated using vasopressin analogues. With the analogues available the receptor specificity of this phenomenon could not be distinguished from those associated with the previously described plasminogen activator release or antidiuretic effects of this hormone. Further studies using 1-desamino-[8-D-arginine]vasopressin showed a dose-related release of both procoagulant and antigenic components of the factor VIII complex. The newly released factor VIII could not be distinguished from circulating factor VIII on the basis of molecular size, electrophoretic mobility or in vitro stability despite apparent differences in the duration of response of the procoagulant and antigenic components in vivo.
TNFRSF25 Agonistic Antibody and Galectin-9 Combination Therapy Controls Herpes Simplex Virus-Induced Immunoinflammatory Lesions (2012)

Ocular infection with herpes simplex virus 1 (HSV-1) results in a chronic immunoinflamammtory reaction in the cornea, which is primarily orchestrated by CD4(+) T cells. Hence, targeting proinflammatory CD4(+) T cells or increasing the representation of cells that regulate their function is a relevant therapeutic strategy. In this report, we demonstrate that effective therapeutic control can be achieved using a combination of approaches under circumstances where monotherapy is ineffective. We use a convenient and highly effective monoclonal antibody (MAb) approach with MAbT25 to expand cells that express the tumor necrosis factor receptor superfamily member 25 (TNFRSF25). In naïve animals, these are predominantly cells that are Foxp3-positive regulatory T cells. MAbT25 treatment before or at the time of initial HSV infection was an effective means of reducing the severity of subsequent stromal keratitis lesions. However, MAbT25 treatment was not effective if given 6 days after infection since it expanded proinflammatory effector T cells, which also express TNFRSF25. Therefore, the MAbT25 procedure was combined with galectin-9 (Gal-9), an approach that compromises the activity of T cells involved in tissue damage. The combination therapy provided highly effective lesion control over that achieved by treatment with one of them. The beneficial outcome of the combination therapy was attributed to the expansion of the regulatory T cell population that additionally expressed activation markers such as CD103 needed to access inflammatory sites. Additionally, there was a marked reduction of CD4(+) gamma interferon-producing effector T cells responsible for orchestrating the tissue damage. The approach that we describe has potential application to control a wide range of inflammatory diseases, in addition to stromal keratitis, an important cause of human blindness.
Numerical algorithms and results for SC-cut quartz plates vibrating at the third harmonic overtone of thickness shear (1994)

Finite element matrix equations, derived from two-dimensional piezoelectric high frequency plate theory are solved to study the vibrational behavior of the third overtone of thickness shear in square and circular SC-cut quartz resonators. The mass-loading and electric effects of electrodes are included. A perturbation method which reduces the memory requirements and computational time significantly is employed to calculate the piezoelectric resonant frequencies. A new storage scheme is introduced which reduces memory requirements for mass matrix by about 90% over that of the envelope storage scheme. Substructure techniques are used in eigenvalue calculation to save storage. Resonant frequency and the mode shapes of the harmonic third overtone thickness shear vibrations for square and circular plates are calculated. A predominant third overtone thickness shear displacement, coupled with the third overtone of thickness stretch and thickness twist, is observed. Weak coupling between the third order thickness shear displacement and the zeroth-, first-, and second-order displacements is noted. The magnitudes of the lower order displacements are found to be about two orders smaller than that of the third overtone thickness shear displacement.
Anti-PcrV antibody in cystic fibrosis: A novel approach targeting <i>Pseudomonas aeruginosa</i> airway infection (2013)

Pseudomonas aeruginosa (Pa) airway infection is associated with increased morbidity and mortality in cystic fibrosis (CF). The type III secretion system is one of the factors responsible for the increased virulence and pro-inflammatory effects of Pa. KB001 is a PEGylated, recombinant, anti-Pseudomonas-PcrV antibody Fab' fragment that blocks the function of Pa TTSS. We studied the safety, pharmacokinetic (PK), and pharmacodynamic properties of KB001 in CF subjects with chronic Pa infection. Twenty-seven eligible CF subjects (≥12 years of age, FEV1 ≥40% of predicted, and sputum Pa density >10(5) CFU/g) received a single intravenous dose of KB001 (3 mg/kg or 10 mg/kg) or placebo. Safety, PK, Pa density, clinical outcomes, and inflammatory markers were assessed. KB001 had an acceptable safety profile and a mean serum half-life of 11.9 days. All subjects had Pa TTSS expression in sputum. There were no significant differences between KB001 and placebo for changes in Pa density, symptoms, or spirometry after a single dose. However, compared to baseline, at Day 28 there was a trend towards a dose-dependent reduction in sputum myeloperoxidase, IL-1, and IL-8, and there were significant overall differences in change in sputum neutrophil elastase and neutrophil counts favoring the KB001 10 mg/kg group versus placebo (-0.61 log(10) and -0.63 log(10) , respectively; P < 0.05). These results support targeting Pa TTSS with KB001 as a nonantibiotic strategy to reduce airway inflammation and damage in CF patients with chronic Pa infection. Repeat-dosing studies are necessary to evaluate the durability of the anti-inflammatory effects and how that may translate into clinical benefit. (NCT00638365).
Technique for Liposuction Fat Reimplantation and Long-Term Volume Evaluation by Magnetic Resonance Imaging (1991)

Injection with one's own fat tissue remains controversial due to a lack of objective data pertaining to postoperative volume control. Facial defects in a total of 53 patients were repaired using autogenous fat tissue. The fatty tissue was obtained from the lower abdomen, buttocks, or inner portion of the upper thigh and then suspended before injection in a solution of 250 ml Ringer's solution, 50 ml distilled water, and 0.7 ml hyaluronidase. The fatty tissue was collected by a filter integrated within the suction system and subsequently prepared, as follows: (1) Cell detritus, blood constituents, and local anesthetic were flushed away by using a physiological Ringer's solution. (2) The defects were filled by using a finely calibrated, locked injection, whereby the desired amount of fatty tissue could be accurately instilled. (3) Injection was carefully performed directly under the cutis through a large lumen cannula and under close observation to avoid the injection of any fatty tissue intracutaneously. Before the procedure, the augmented areas had been evaluated by using magnetic resonance imaging (in T1-weighted images). Postoperatively, the sites were once again documented for volume at control intervals of 6 days, and 3, 6, 9, and 12 months. The volumes were computer-calculated integrally from the sum of the area of all the layers according to the following formula:v = (d + g).E(ai). Despite the use of hyaluronidase as well as an atraumatic liposuction technique, microscopic examination revealed 40% of the aspirated cells to have defective cell membranes. Without hyaluronidase, this figure rose to 50%. One-year follow-up in 10 patients showed that through the break-down of these damaged cells, a particularly high volume loss of 49% was documentable at 3 months after the procedure. Further follow-up at 6 months showed that average volume decline had risen to a total of 55%, whereas, at 9 months as well as 12 months, no further loss could be detected. Autogenous fat transplantation after liposuction is a procedure only suitable for the repair of small, soft-tissue defects, especially of the face. The individual deposits should not be any larger than 1 ml, whereby intact fat cells are guaranteed sufficient diffusion up to the point of neovascularization. It is essential that the fatty tissue injection be exactly administered subcutaneously. Together with basic clinical observation, magnetic resonance imaging provides an objective evaluation of volume loss with an average error of only 5%.
Parametric Modeling of Narrowband UV-B Phototherapy for Vitiligo Using a Novel Quantitative Tool (2004)

The VASI is a quantitative clinical tool that can be used to evaluate vitiligo parametrically. Patients treated with NB-UV-B can be expected to achieve approximately 42.9% repigmentation of their vitiligo after 6 months of treatment, with the greatest response being achieved over the trunk and nonacral portions of the extremities.
Oxygen free radicals in acute renal failure. (1991)

Renal ischemia injures the renal tubular cell by disrupting the vital cellular metabolic machinery. Further cell damage is caused by restoration of blood flow when oxygen free radicals are produced. Cellular sources of oxygen free radicals include the electron transport chain, the microsomal electron transport chain, oxidant enzymes (xanthine oxidase, cyclo-oxygenase), phagocytes, and cellular auto-oxidation of Fe2+ and epinephrine. Oxygen radicals cause lipid peroxidation of cell and organelle membranes, disrupting the structural integrity and capacity for cell transport and energy production. Studies in models of acute renal failure have yielded convincing evidence that oxygen free radical production occurs during ischemia/reperfusion. More than a dozen reports have demonstrated the ability of exogenous antioxidants to ameliorate renal injury in vivo. Direct demonstration of increased oxygen free radical production during reoxygenation following hypoxia has been shown in cultured renal epithelial cells. Oxygen free radicals also play a role in toxic acute renal failure. The therapeutic usefulness of free radical scavengers remains to be tested.
Micro-kinetic generator: Modeling, energy conversion optimization and design considerations (2010)

This article focuses on a micro-kinetic generator, which is used in Autoquartz watches designed by the Swiss manufacturer ETA (part of the Swatch Group). This original electromechanical system, incorporating an intermediate energy storage located in a spring, is based on harnessing the energy from movement. We have built an electromechanical model using the Matlab Simulink application and proceeded with its experimental validation on various movement profiles. Our research has highlighted the existence of an optimal transfer of energy (obtained by either influencing generator design or regulating output voltage of the active rectifier connected to the generator) that helps maximize energy recovery. Finally, this paper presents the results of a system resizing study for the purpose of studying potential system productivity at other scales, and highlights the existence of an optimal set of parameters maximizing energy recovery.
Control Algorithm for Coordinated Reactive Power Compensation in a Wind Park (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The penetration level of wind energy is continuously growing, and it is especially relevant in European countries such as Denmark, Germany, and Spain. For this reason, grid codes in different countries have been recently revised, or are now under revision in order to integrate this energy in the network taking into account the security of supply. This paper is related to reactive compensation, which is one aspect usually included in these codes. On the other hand, a great number of installed wind parks are formed by fixed speed wind turbines equipped with induction generators. The typical scheme for reactive compensation in this kind of wind parks is based on capacitor banks locally controlled in each machine. This configuration makes very difficult to follow the requirements of the new grid codes. To overcome this problem, a configuration with a central controller that coordinates the actuation over all the capacitor steps in the wind park is proposed in this paper. A central controller algorithm that is based on a dynamic programming is presented and evaluated by means of simulation. At this time, the proposed scheme has been installed at the Sotavento Experimental Wind Park (Spain) and it is currently being tested. </para>
Very Fast Short Circuit Protection for Gallium-Nitride Power Transistors Based on Printed Circuit Board Integrated Current Sensor (2018)

Gallium-Nitride power transistors have a limited short-circuit withstand time, which can be as low as 200 ns. Typical short-circuit detection methods such as the desaturation detection method and current based methods present difficulties when they are applied to Gallium Nitride devices. The former requires a blanking time and therefore can detect a short-circuit at a relatively late stage, this method also reacts slowly under high-inductive short circuits. Current based methods require either a special transistor with a current mirror or a special package with a Kelvin connection. This work presents the use of a current sensor integrated into a printed circuit board to perform a very fast short-circuit detection. Two detection methods using the integrated current sensor were implemented, which neither use a blanking time nor require a special transistor package. The functioning under both Hard Switch Fault and Fault Under Load types of short circuit was experimentally tested and a resulting short circuit detection time as low as 30 ns is demonstrated.
Optical Cavity Effects in ZnO Nanowire Lasers and Waveguides (2003)

Wide band gap semiconductor nanostructures with near-cylindrical geometry and large dielectric constants exhibit two-dimensional ultraviolet and visible photonic confinement (i.e., waveguiding). Combined with optical gain and suitable resonant feedback, the waveguiding behavior facilitates highly directional lasing at room temperature in controlled-growth nanowires. We have characterized the nanowire emission in detail with high-resolution optical microscopy. The waveguiding behavior of individual zinc oxide (ZnO) nanowires depends on the wavelength of the emitted light and the directional coupling of the photoluminescence (PL) to the emission dipoles of the nanowire. Polarization studies reveal two distinct regimes of PL characterized by coupling to either guided (bound) or radiation modes of the waveguide, the extent of which depends on wire dimensions. Pumping with high pulse energy engenders the transition from spontaneous to stimulated emission, and analysis of the polarization, line width, and line spacing of the laser radiation facilitates identification of the transverse and longitudinal cavity modes and their gain properties. Interpretation of the lasing spectra as a function of pump fluence, with consideration of ZnO material properties and ultrafast excitation dynamics, demonstrates a transition from exciton (fluence < 1 μJ/cm2) to electron−hole plasma dynamics (fluence > 1 μJ/cm2) and gain saturation behavior (fluence > 3 μJ/cm2) modified by the constraints of the nanoscale cylindrical cavity.