gebhart/patrepeval huggingface dataset:
Robot Path Planning with Avoiding Obstacles in Known Environment Using Free Segments and Turning Points Algorithm (2018)

Currently, the path planning problem is one of the most researched topics in autonomous robotics. That is why finding a safe path in a cluttered environment for a mobile robot is an important requirement for the success of any such mobile robot project. In this work, a developed algorithm based on free segments and a turning point strategy for solving the problem of robot path planning in a static environment is presented. The aim of the turning point approach is to search a safe path for the mobile robot, to make the robot moving from a starting position to a destination position without hitting obstacles. This proposed algorithm handles two different objectives which are the path safety and the path length. In addition, a robust control law which is called sliding mode control is proposed to control the stabilization of an autonomous mobile robot to track a desired trajectory. Finally, simulation results show that the developed approach is a good alternative to obtain the adequate path and demonstrate the efficiency of the proposed control law for robust tracking of the mobile robot.
myo-Inositol Monophosphatase Is an Activated Target of Calbindin D28k (2002)

Calbindin D(28k) (calbindin) is a member of the calmodulin superfamily of Ca(2+)-binding proteins. An intracellular target of calbindin was discovered using bacteriophage display. Human recombinant calbindin was immobilized on magnetic beads and used in affinity purification of phage-displayed peptides from a random 12-mer peptide library. One sequence, SYSSIAKYPSHS, was strongly selected both in the presence of Mg(2+) and in the presence of Ca(2+). Homology search against the protein sequence data base identified a closely similar sequence, ISSIKEKYPSHS, at residues 55-66 in myo-inositol-1(or 4)-monophosphatase (IMPase, EC ), which constitute a strongly conserved and exposed region in the three-dimensional structure. IMPase is a key enzyme in the regulation of the activity of the phosphatidylinositol-signaling pathway. It catalyzes the hydrolysis of myo-inositol-1(or 4)-monophosphate to form free myo-inositol, maintaining a supply that represents the precursor for inositol phospholipid second messenger signaling systems. Fluorescence spectroscopy showed that isolated calbindin and IMPase interact with an apparent equilibrium dissociation constant, K(D), of 0.9 microm. Both apo and Ca(2+)-bound calbindin was found to activate IMPase up to 250-fold, depending on the pH and substrate concentration. The activation is most pronounced at conditions that otherwise lead to a very low activity of IMPase, i.e. at reduced pH and at low substrate concentration.
Multiple Description Coding for H.264/AVC With Redundancy Allocation at Macro Block Level (2011)

In this paper, a novel multiple description video coding scheme is proposed to insert and control the redundancy at macro block (MB) level. By analyzing the error propagation paths, the relative importance of each MB is determined. The paths, in practice, depend on both the video content and the adopted video coder. Considering the relative importance of the MB and the network status, an unequal protection for the video data can be realized to exploit the redundancy effectively. In addition, a simple and effective approach is introduced to tune the quantization parameter for the variable rate coding case. The whole scheme is implemented in H.264/AVC by employing its coding options, thus generating descriptions that are compatible with the baseline profile and extended profile of H.264/AVC. Due to its general property, the proposed approach can be employed for other hybrid video codecs. The results demonstrate the advantage of the proposed approach over other H.264/AVC multiple description schemes.
DNA methylation and sensitivity to antimetabolites in cancer cell lines (2008)

The prediction of the cellular direction of metabolic pathways toward either DNA synthesis or DNA methylation is crucial for determining the susceptibility of cancers to anti-metabolites such as fluorouracil (5-FU). We genotyped the methylenetetrahydrofolate reductase (MTHFR) gene in NCI-60 cancer cell lines, and identified the methylation status of 24 tumor suppressor genes using methylation-specific multiplex ligation-dependent probe amplification. The susceptibility of the cancer cell lines to seven antimetabolites was then determined. Cells homozygous for CC at MTHFR-A1298C were significantly more sensitive to cyclocytidine, cytarabine (AraC) and floxuridine than those with AA or AC (p=0.0215, p=0.0166, and p=0.0323, respectively), and carried more methylated tumor suppressor genes (p=0.0313). Among the 12 tumor suppressor genes which were methylated in >25% of cancer cell lines, the methylation status of TIMP3, APC and IGSF4 significantly correlated with sensitivity to pyrimidine synthesis inhibitors. In particular, cells with methylated TIMP3 had reduced mRNA levels and were significantly more sensitive to aphidicolin-glycinate, AraC and 5-FU than cells with unmethylated TIMP3. We speculate that MTHFR-A1298C homozygous CC might direct the methylation rather than the synthesis of DNA, and result in the methylation of several tumor suppressor genes such as TIMP3. These genes could be useful biological markers for predicting the efficacy of antimetabolites.
The architectural costs of streaming I/O: A comparison of workstations, clusters, and SMPs (2002)

We investigate resource usage while performing streaming I/O by contrasting three architectures, a single workstation, a cluster, and an SMP, under various I/O benchmarks. We derive analytical and empirically-based models of resource usage during data transfer, examining the I/O bus, memory bus, network, and processor of each system. By investigating each resource in detail, we assess what comprises a well-balanced system for these workloads. We find that the architectures we study are not well balanced for streaming I/O applications. Across the platforms, the main limitation to attaining peak performance is the CPU, due to lack of data locality. Increasing processor performance (especially with improved block operation performance) will be of great aid for these workloads in the future. For a cluster workstation, the I/O bus is a major system bottleneck, because of the increased load placed on it from network communication. A well-balanced cluster workstation should have copious I/O bus bandwidth, perhaps via multiple I/O busses. The SMP suffers from poor memory-system performance; even when there is true parallelism in the benchmark, contention in the shared-memory system leads to reduced performance. As a result, the clustered workstations provide higher absolute performance for streaming I/O workloads.
Vancomycin‐Resistant<i>Staphylococcus aureus</i>in the Absence of Vancomycin Exposure (2004)

We report findings from our investigation of the world's second clinical isolate of vancomycin-resistant Staphylococcus aureus (VRSA). An elderly man was hospitalized with an infected chronic heel ulcer and osteomyelitis. Before hospital admission, he received multiple courses of antibiotic therapy but, notably, no vancomycin. Numerous cultures of ulcer specimens (performed on an outpatient basis) grew methicillin-resistant, vancomycin-susceptible S. aureus and vancomycin-resistant Enterococcus species. At admission, an additional culture of a specimen from the heel ulcer grew S. aureus that was identified as VRSA (minimal inhibitory concentration for vancomycin [by broth-microdilution], 32 microg/mL). Further evaluation confirmed the presence of the vanA gene mediating vancomycin resistance. To assess VRSA transmission, we performed a carriage study of 283 identified contacts and an environmental survey of the patient's home; no VRSA isolates were recovered. This case illustrates that recent exposure by patients to vancomycin is not necessary for development of vanA-containing VRSA. For clinical and public health reasons, it is essential that microbiology laboratories adequately test for vancomycin-resistance in S. aureus.
THE STIMULATORY EFFECT OF CYCLIC ADENOSINE 3′5′-MONOPHOSPHATE ON DNA-DIRECTED SYNTHESIS OF β-GALACTOSIDASE IN A CELL-FREE SYSTEM (1969)

A cell-free system allowing for synthesis of beta-galactosidase enzymatic activity has been developed. This system requires DNA containing the beta-galactosidase gene, a cell-free extract of Escherichia coli bacteria, and the low-molecular-weight components necessary for transcription of the DNA and translation of the resulting messenger RNA. Such a system is useful for studying enzyme synthesis, as well as its regulation. The gene for beta-galactosidase is part of the lac operon whose expression is under the control of the lac repressor. In whole cells the lac repressor inhibits almost all of the gene expression for beta-galactosidase. In the cell-free system, we had previously been able to repress about half the gene expression. Adding cyclic adenosine 3'5'-monophosphate to the cell-free system improved the yield of beta-galactosidase enzymatic activity by 8 to 30 times and the efficiency of repression from 50 to 95 per cent.
3GPP LTE-Assisted Wi-Fi-Direct: Trial Implementation of Live D2D Technology (2015)

<p>This paper is a first-hand summary on our comprehensive live trial of cellular-assisted device-todevice (D2D) communications currently being ratified by the standards community for next-generation mobile broadband networks. In our test implementation, we employ a full-featured 3GPP LTE network deployment and augment it with all necessary support to provide realtime D2D connectivity over emerging Wi-Fi-Direct (WFD) technology. As a result, our LTE-assisted WFD D2D system enjoys the required flexibility while meeting the existing standards in every feasible detail. Further, this paper provides an account on the extensive measurement campaign conducted with our implementation. The resulting real-world measurements from this campaign quantify the numerical effects of D2D functionality on the resultant system performance. Consequently, they shed light on the general applicability of LTE-assisted WFD solutions and associated operational ranges.</p>
Cholesteric liquid crystal laser with wide tuning capability (2005)

This letter examines a planar cholesteric cell (CLC) doped with two collocated laser dyes as a one-dimensional photonic crystal. Adding phototunable chiral material (AzoB) allows the CLC photonic crystal to be lased at the band edges of the photonic band gap with a tuning range of over 100nm. Tuning is performed by irradiating the chiral AzoB material with UV light, causing the material to undergo trans-cis isomerization in the CLC film. The tuning range is the visible region from 563to667nm. Moreover, the tuning is reversible.
Anticoagulation for stroke prevention in elderly patients with non-valvular atrial fibrillation: what are the obstacles? (2016)

The elderly with atrial fibrillation are more prone to stroke. Oral anticoagulants such as warfarin are effective in the prevention of atrial fibrillation-associated stroke and systemic embolism. The CHADS<sub>2</sub> or CHA<sub>2</sub>D<sub>2</sub>-VASc score and HAS-BLED score were developed to stratify stroke risk associated with atrial fibrillation and bleeding risk in a patient with atrial fibrillation, respectively, to facilitate the decision for and safe use of oral anticoagulant. Nonetheless, the decision for anticoagulation is not straightforward and the elderly with non-valvular atrial fibrillation are often precluded from anticoagulant prescription. Advanced age and disadvantages associated with the elderly such as fall, comorbidities, cognitive impairment, and polypharmacy contribute to the over-concern of physicians about bleeding risk. Various treatment options such as low-intensity warfarin and aspirin plus clopidogrel have been suggested but are inferior to dose-adjusted warfarin. Novel oral anticoagulants with promising efficacy and convenience hold great appeal. Optimal management of underlying medical conditions and modifiable stroke risk factors, together with intervention to improve the safe use of oral anticoagulants, are useful.
Tritium Separation by CO<sub>2</sub>Laser Multiphoton Dissociation of Trifluoromethane (1980)

KEYWORDS: isotope separationlaser isotope separationhydrogen isotopestritiuminfrared lasercarbon dioxide lasermultiphoton dissociationtrifluoromethaneradio gas chromatography
Leukocyte complement: a possible role for C5 in lymphocyte stimulation. (1983)

The results presented here show that Fab' antibody fragments directed to complement proteins C5, C6, and C7 inhibit lymphocyte stimulation in mixed lymphocyte culture (MLC) by up to 65%, as determined by decreased incorporation of 3H-thymidine. Lymphocyte stimulation induced by PHA-mitogen was also inhibited up to 100% by anti-C5 Fab'. Specificity of these reactions was established by the findings that goat anti-C5 or murine hybridoma anti-C5 both inhibited MLC; the inhibitory activity of anti-C5 Fab' was absorbed with highly purified C5 (but not with C3), and antibody directed to C3 did not inhibit lymphocyte stimulation by MLC or PHA. The effects of anti-C5 were exerted in a nontoxic manner. Cleavage of lymphocyte associated C5 with factor B (Bb) or with trypsin resulted in stimulation of lymphocyte thymidine incorporation. Purified C5a was found to induce lymphocyte stimulation in serum-free medium in pulse-chase types of experiments. Anti-C6 and C7 Fab' also inhibited lymphocyte stimulation induced in one-way MLC. These results suggest that C5, C5a, and/or C6 and C7 may play a role in triggering of lymphocyte blastogenesis.
Doublet frequencies in evolutionary distinct groups (1984)

We analyze the dinucleotide frequencies of occurrence and preferences separately within the vertebrates, nonvertebrates, DNA viruses, mitochondria, RNA viruses, bacteria and phage sequences. Over half a million nucleotides from more than 400 sequences were used in this study. Distinct patterns are observed. Some of the patterns are common to all sequences, some to either eukaryotes or prokaryotes and others to the subgroups within them. Doublets are the most basic ingredient of order in nucleotide sequences. We suggest that their preferences and the arrangement of nucleotides in the DNA in general is determined to a large extent by the conformational and packaging considerations of the double helix. Some principles of DNA conformation are viewed in light of our results.
Secondary ion quadrupole mass spectrometer for depth profiling—design and performance evaluation (1978)

A quadrupole-based secondary ion mass spectrometer designed for depth profiling is described which combines ultrahigh vacuum construction with high sputtering rate, detection sensitivity, depth resolution, mass spectral purity, and abundance sensitivity. Impurities such as B and Al implanted in Si can be profiled to levels below one part per million atomic (ppma), at a depth resolution equal to that obtained by commercial ion microprobes. The primary beam consists of 5-keV, mass-analyzed (40)Ar(+) ions, focused to about 70 microm in diameter. Its high current density (>25mA/cm(2)) permits adequate beam rastering and electronic signal-gating to optimize depth resolution. A secondary ion extraction lens and spherical energy filter are responsible for achieving abundance sensitivities of five to six orders of magnitude on the low mass side of a matrix peak. The ultrahigh vacuum environment of the sample dramatically reduces molecular peaks containing H, C, and O, allowing even hydrogen to be profiled to concentrations below 10 ppma. Because large amounts of data are generated by multi-element depth profiling, means for automated instrument control and data acquisition have been developed.
First step to combining control and data speculation (2005)

Recently there are many studies of data value prediction for increasing instruction level parallelism, and it is found that data speculation affects branch prediction accuracy. Even when data dependences are speculated successfully, processor performance would be degraded if branch prediction accuracy were decreased. On the other hand, branch prediction studies are nearly matured. While it becomes very difficult to increase the accuracy, there is still a vast gap between actual and ideal processor performance. From these considerations, we investigate to combine control and data speculation. Here, we evaluate the correlation between control speculation and data speculation and then propose to predict branch outcomes using data value prediction. Keywords: instruction level parallelism, speculative execution, branch prediction, value prediction, speculative verification.
Light-induced Dissociation of an Antenna Hetero-oligomer Is Needed for Non-photochemical Quenching Induction (2009)

PsbS plays a major role in activating the photoprotection mechanism known as "non-photochemical quenching," which dissipates chlorophyll excited states exceeding the capacity for photosynthetic electron transport. PsbS activity is known to be triggered by low lumenal pH. However, the molecular mechanism by which this subunit regulates light harvesting efficiency is still unknown. Here we show that PsbS controls the association/dissociation of a five-subunit membrane complex, composed of two monomeric Lhcb proteins (CP29 and CP24) and the trimeric LHCII-M. Dissociation of this supercomplex is indispensable for the onset of non-photochemical fluorescence quenching in high light, strongly suggesting that protein subunits catalyzing the reaction of heat dissipation are buried into the complex and thus not available for interaction with PsbS. Consistently, we showed that knock-out mutants on two subunits participating to the B4C complex were strongly affected in heat dissipation. Direct observation by electron microscopy and image analysis showed that B4C dissociation leads to the redistribution of PSII within grana membranes. We interpreted these results to mean that the dissociation of B4C makes quenching sites, possibly CP29 and CP24, available for the switch to an energy-quenching conformation. These changes are reversible and do not require protein synthesis/degradation, thus allowing for changes in PSII antenna size and adaptation to rapidly changing environmental conditions.
217 (2012)

Introduction: The aim of our study was to determine the degree of edema in the organs of patients who died with severe sepsis. Hypothesis: In severe sepsis, alterations in vascular permeability result in organ edema. The increase in weight may vary according to the organ considered. Methods: Autopsies are still routinely performed in patients who die in our 35 bed Multidisciplinary Department of Intensive Care. We reviewed the data and the organ weights of all patients who had a postmortem examination in the years 2008- 2011. We extracted a group (n=171) of patients with severe sepsis and a control group of patients who died without evidence of infection (n=54). Results: Total lung weight was significantly greater in septic than in non-infected patients (1591 ± 541 vs. 1306 ± 417 g, p<.001). These differences remained when only septic patients without pulmonary infection (n=74) were kept in the analysis (1509 ± 570 g, p=.028). The spleens were heavier in the sepsis group than in the control group (262 ± 175 vs. 180 ± 83 g, p<0.001) and changes in kidney weight almost reached statistical significance (346 ± 116 vs. 312 ± 100 g, p=.058). No significant difference was found in the weight of heart, liver, brain and thyroid gland. Septic patients with cirrhosis (n=59) had particularly heavy lung, spleen and kidney weight. Conclusions: Among non-survivors, septic patients have more edema in their lungs and spleen and perhaps kidneys than non-infected patients. However, their heart, liver, and brain are not heavier than in other ICU patients.
The <i>katX</i> Gene, Which Codes for the Catalase in Spores of <i>Bacillus subtilis</i> , Is a Forespore-Specific Gene Controlled by ς <sup>F</sup> , and KatX Is Essential for Hydrogen Peroxide Resistance of the Germinating Spore (1998)

Previous work has shown that the katX gene encodes the major catalase in dormant spores of Bacillus subtilis but that this enzyme has no role in dormant spore resistance to hydrogen peroxide. Expression of a katX-lacZ fusion began at approximately h 2 of sporulation, and >75% of the katX-driven beta-galactosidase was packaged into the mature spore. A mutation in the gene coding for the sporulation-specific RNA polymerase sigma factor sigmaF abolished katX-lacZ expression, while mutations in genes encoding sigmaE, sigmaG, and sigmaK did not. Induction of sigmaF synthesis in vegetative cells also resulted in katX-lacZ expression, while induction of sigmaG expression did not; the katX-lacZ fusion was also not induced by hydrogen peroxide. Upstream of the in vivo katX transcription start site there are sequences with good homology to those upstream of known sigmaF-dependent start sites. These data indicate that katX is an additional member of the forespore-specific sigmaF regulon. A mutant in the katA gene, encoding the major catalase in growing cells, was sensitive to hydrogen peroxide during sporulation, while a katX mutant was not. However, outgrowth of katX spores, but not katA spores, was sensitive to hydrogen peroxide. Consequently, a major function for KatX is to protect germinating spores from hydrogen peroxide.
Novel antibodies targeting immune regulatory checkpoints for cancer therapy (2013)

Cancers must evade or suppress the immune system in order to develop. Better understanding of the molecular regulation governing tumour detection and effective activation of the immune system (so called immune regulatory checkpoints) has provided new targets for cancer immunotherapy. Therapeutic monoclonal antibodies against these targets are currently undergoing clinical evaluation with more in pre-clinical development; buoyed by the recent licence approval of the anti-CTLA-4 antibody, ipilumumab, for use in melanoma. This article will review the current status of the various antibodies and target molecules being investigated.
Release of Hydrophobic Substances from Polystyrene-Methacrylic Acid Block Copolymer Micelles into Aqueous Media (1995)

Abstract Block copolymer micelles are potential carriers for controlled-release drug delivery. In this study, the fundamental aspects of the release of a model compound from the micelles into the surrounding media were explored. A fluorescence-based technique was developed for following the release of the model compound from the cores of block copolymer micelles into aqueous media. The experimental release curves were compatible with theoretical dependences for diffusion controlled release from spherical particles. The diffusion coefficients found were of the order of 1018 cm2/s, which was expected for molecules with sizes of our probes and glassy polystyrene. The partition coefficients are also of the expected order of 105 magnitude. The fraction of the probe present outside of the cores at the start of the experiment may serve to characterize the efficiency of various procedures for the loading of various agents into the core.
A current-controlled quasi-resonant converter for switched-reluctance motor (1991)

A current-controlled quasi-resonant power converter suitable for switched-reluctance motor (SRM) feeding is presented. The converter operation is analyzed and its characteristics are determined in terms of the system parameters. The converter control strategy is studied for different operating conditions. Current control operation is considered and discussed. Theoretical predictions are verified and validated by experimental results obtained with a prototype SRM drive.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>