gebhart/patrepeval huggingface dataset:
Synthesis and characteristics of polyelectrolyte complexes composed of chitosan and hyaluronic acid (2004)

Abstract Polyelectrolyte complexes (PEC) composed of various weight ratios of chitosan and hyaluronic acid (HA) were prepared. The PECs were formed by a reaction of the oppositely charged polymers. The characterizations of the PEC films were investigated by using Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The PECs were found to swell rapidly, reaching equilibrium within 30 min, and exhibited relatively high swelling ratios of 250–325% at room temperature. The swelling ratio increased when the pH of the buffer was below pH 6, as a result of the dissociation of the ionic bonds, and with increments of temperature. Therefore, the swelling ratios of the films were pH and temperature dependent. DSC was used to determine the amount of free water in the PEC films, which increased with increasing chitosan content. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 91: 2908–2913, 2004
Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer (2016)

Scleroderma is a chronic autoimmune rheumatic disease associated with widespread tissue fibrosis and vasculopathy. Approximately two-thirds of all patients with scleroderma present with three dominant autoantibody subsets. Here, we used a pair of complementary high-throughput methods for antibody epitope discovery to examine patients with scleroderma with or without known autoantibody specificities. We identified a specificity for the minor spliceosome complex containing RNA Binding Region (RNP1, RNA recognition motif) Containing 3 (RNPC3) that is found in patients with scleroderma without known specificities and is absent in unrelated autoimmune diseases. We found strong evidence for both intra- and intermolecular epitope spreading in patients with RNA polymerase III (POLR3) and the minor spliceosome specificities. Our results demonstrate the utility of these technologies in rapidly identifying antibodies that can serve as biomarkers of disease subsets in the evolving precision medicine era.
Mortality Associated with Nosocomial Urinary-Tract Infection (1982)

In a prospective study, 131 of 1458 patients acquired 136 urinary-tract infections (defined as greater than 10(5) colony-forming units per milliliter) during 1474 indwelling bladder catheterizations. Seventy-six patients (25 infected and 51 noninfected) died during hospitalization; death rates were 19 per cent in infected patients and 4 per cent in noninfected patients. Multiple logistic regression analysis demonstrated that seven of 21 prospectively monitored variables were associated with mortality among the catheterized patients. The adjusted odds ratio for mortality between those who acquired infection and those who did not was 2.8 (95 per cent confidence limits, 1.5 to 5.1). The acquisition of infection as not associated with the severity of underlying disease; among patients who died, infections occurred in 38 per cent of those classified as having nonfatal underlying disease (15 of 39) and in 27 per cent of those classified as having fatal disease (10 of 37). Twelve deaths may have been caused by acquired urinary-tract infections. Two patients had urinary-tract pathogens in premortem blood cultures. Another 10 died with clinical pictures compatible with serious infection, but no diagnostic cultures were performed. We conclude that the acquisition of urinary-tract infection during indwelling bladder catheterization is associated with nearly a threefold increase in mortality among hospitalized patients, but the reason for this association is not yet clear.
Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke (2012)

Brain repair involves a compendium of natural mechanisms that are activated following stroke. From a therapeutic viewpoint, reparative therapies that encourage cerebral plasticity are needed. In the last years, it has been demonstrated that modulatory treatments for brain repair such as trophic factor- and stem cell-based therapies can promote neurogenesis, gliogenesis, oligodendrogenesis, synaptogenesis and angiogenesis, all of which having a beneficial impact on infarct volume, cell death and, finally, and most importantly, on the functional recovery. However, even when promising results have been obtained in a wide range of experimental animal models and conditions these preliminary results have not yet demonstrated their clinical efficacy. Here, we focus on brain repair modulatory treatments for ischaemic stroke, that use trophic factors, drugs with trophic effects and stem cell therapy. Important and still unanswered questions for translational research ranging from experimental animal models to recent and ongoing clinical trials are reviewed here.
Synthesis of new earthy odorants. (1992)

Several derivatives of cyclohexanol and fenchol have been synthesized, as structural models of geosmin, with the aim to provide easy to make and cheap earthy odorants. 1,2,2,6-Tetramethylcyclohexanol and I-ethyl-2,2,6-trimethylcyclohexanol had odors very similar to that of geosmin. All of the compounds were synthesized in one step from cheap and readily available ketones, by reaction with Grignard or lithium derivatives. In some cases diastereoisomers were separated and the odors found to be markedly different. The products obtained from the two enantiomeric forms of fenchone also exhibited different odors.
Placental Interferons (1996)

Trophectoderm of ruminant conceptuses (embryo and associated membranes) secrete tau interferons (IFN tau) as the pregnancy recognition signal. Secretion of IFN tau on gestational days 12-13 for sheep and gestation days 14-17 for cows and goats is critical for pregnancy recognition. IFN tau acts on uterine epithelium to suppress estrogen receptor and oxytocin receptor gene expression, which prevents uterine release of luteolytic pulses of prostaglandin F2 alpha (PGF). Expression of the progesterone receptor (PR) gene in uterine endometrium is not affected by oIFN tau. Maintenance of progesterone secretion by the corpus luteum (CL) ensures establishment of pregnancy. Pig conceptuses secrete both IFN alpha and IFN gamma between days 15-21 of gestation, but their role(s) in early pregnancy is unknown. Estrogen secreted by pig trophoblast between gestational days 11-13 and 15-25 increases endometrial receptors for prolactin and causes exocrine secretion of PGF into the uterine lumen to prevent luteolysis. Shared cell-signaling mechanisms by IFNs and lactogenic hormones through Janus kinases (JAK) 1 and 2 may provide a common pathway to abrogate luteolytic mechanisms to ensure establishment of pregnancy. The role(s) of IFNs produced by human and rodent placentae is not known.
Modified pseudo LRU replacement algorithm (2006)

Although the LRU replacement algorithm has been widely used in cache memory management, it is well-known for its inability to be easily implemented in hardware. Most of primary caches employ a simple block replacement algorithm like pseudo LRU to avoid the disadvantages of a complex hardware design. In this paper, we propose a novel block replacement scheme, MPLRU (modified pseudo LRU), by exploiting second chance concept in pseudo LRU algorithm. A comprehensive comparison is made between our algorithm and both true LRU and other conventional schemes such as FIFO, random and pseudo LRU. Experimental results show that MPLRU significantly reduces the number of cache misses compared to the other algorithms. Simulation results reveal that in average our algorithm can provide a value of 8.52% improvement on the miss ratio compared to the pseudo LRU algorithm. Moreover, it provides 7.93% and 11.57%performance improvement compared to FIFO and random replacement policies respectively
Cathepsin Inhibition Induces Apoptotic Death in Human Leukemia and Lymphoma Cells (2000)

We examined the effects of cathepsin inhibitor 1 (CATI-1), a selective inhibitor of cysteine cathepsins, on human leukemia and lymphoma cells. CATI-1 induced apoptosis in all 12 cell lines tested. Apoptosis of CATI-1-treated leukemia/lymphoma cells was caspase-independent, p53-independent, BAX-independent as well as MAP kinase-independent. Our findings provide unprecedented experimental evidence that cathepsins play a pivotal role for the survival of human leukemia/lymphoma cells. Therefore, cathepsin inhibitors may provide the basis for new treatment programs against leukemia and lymphoma.
Ethanol‐mediated suppression of <scp>IL</scp>‐37 licenses alcoholic liver disease (2017)

We provide evidence for an exogenous noxae that suppresses Interleukin 37 expression which limits its anti-inflammatory effects in alcoholic liver disease.
Elastin Degradation by Human Alveolar Macrophages: A Prominent Role of Metalloproteinase Activity (1989)

Macrophages are thought to play an important role in the turnover of extracellular matrix, but the capacity of human macrophages to degrade elastin, and the elastolytic mechanisms of these cells, have been controversial. Particular difficulty has been encountered in efforts to establish whether human macrophages secrete a metalloelastase that is analogous to the enzyme secreted by rodent macrophages. We studied elastin degradation by human alveolar macrophages cultured directly in contact with radiolabeled elastin using media containing 10% fetal bovine serum, and for comparison performed parallel studies of P388D1 murine macrophagelike cells that are known to secrete metalloelastase. With both cell types, we observed elastin degradation and the following: (1) direct contact between the cells and elastin substrate was required for elastin degradation; (2) elastin degradation was inhibited by the tissue inhibitor of metalloproteinases, but minimally or not at all by inhibitors of cysteine proteinases (E-64, CBZ-phe-phe-CHN2, CBZ-phe-ala-CHN2, and cystatin C), or by the serine proteinase inhibitor eglin-c; (3) elastin degradation increased sharply after the cells were in contact with elastin for 24 h, and required new protein synthesis as indicated by sensitivity to cycloheximide; (4) inclusion of dexamethasone (10(-6) to 10(-8) M) in the cultures led to decreased elastin degradation. Also, with both cell types, elastin degradation occurred despite the finding that cell-conditioned media did not contain elastase activity and could inhibit P388D1-derived metalloproteinase elastase. These results indicate a prominent role for metalloproteinase activity in elastin degradation by both human and murine macrophages and support the concept that events at the cell-substrate interface are critically important to macrophage-mediated elastin degradation.
El pinball proteico (2015)

Fil: Ferreiro, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Performance of LTE Release 8 and Release 10 in wireless communications (2012)

LTE-Advanced (Release 10) is a preliminary mobile communication standard formally submitted as a candidate 4G systems to the ITU-T. It is being standardized by the 3rd Generation Partnership Project (3GPP) as a major enhancement of the 3GPP Long Term Evolution (LTE-Release 8) standard, which proved to be sufficient to satisfy market's demand. The 3GPP group has been working on different aspects to improve LTE performance, where the purpose of the framework provided by LTE-Advanced, includes higher order MIMO, carrier aggregation (carriers with multiple components), and heterogeneous networks (relays, picos). This paper presents a study on evolution LTE toward LTE-Advanced in terms of LTE enabling technologies (Orthogonal Frequency Division Multiplexing (OFDM) and Multiple-Input Multiple-Output (MIMO)). This paper also focuses on LTE-Advanced technologies MIMO enhancements for LTE-Advanced, Coordinated Multi Point transmission (CoMP), repeaters and relays.
Orthodontic scanners: what’s available? (2015)

The popularity and availability of virtual technology in orthodontics for the replacement of hard-copy records with electronic records is growing rapidly, with a move towards a 'digital' patient for diagnosis, treatment planning, monitoring of treatment progress and outcome. As part of this ongoing development, three-dimensional digital models of the dental arches have the potential to replace traditional plaster models and their associated limitations for treatment planning, appliance construction and simulated treatment outcomes. This article provides the reader with a summary of the currently available benchtop model scanners and intraoral scanners. It is likely that this technology will become increasingly common-place within the orthodontic profession over the next decade.
Observation of strong bulk oxidation effects in amorphous germanium by ultraviolet reflectance spectroscopy (1974)

The effect of air exposure on the reflectance of evaporated amorphous and crystalline germanium for photon energies 2.5 ≤ h ν ≤ 11.7 eV has been studied in order to compare their oxidation rates. For h ν ≳ 4 eV, much larger changes in reflectance are observed in the amorphous films than are found in the crystalline films.
Improved Procedures for Converting Higher α-Olefins to Methyl Ketones with Palladium Chloride (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImproved Procedures for Converting Higher α-Olefins to Methyl Ketones with Palladium ChlorideWilliam H. Clement and Charles M. SelwitzCite this: J. Org. Chem. 1964, 29, 1, 241–243Publication Date (Print):January 1, 1964Publication History Published online1 May 2002Published inissue 1 January 1964https://pubs.acs.org/doi/10.1021/jo01024a517https://doi.org/10.1021/jo01024a517research-articleACS PublicationsRequest reuse permissionsArticle Views1107Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Poster abstract (2008)

We propose a Scalable and Collaborative Internet Access approach, called SCIA, for mobile web surfing. Unlike traditional approaches, the proposed scheme implements a Collaborative Forwarding algorithm that takes advantage of opportunistic wireless connections, and thus improves network capacity by exploiting the diversity of network mobility. Moreover, using the Layered Multiple Description Coding (LMDC) algorithm, the SCIA scheme allows the end user to 'preview' the web content, even before the data has been completely transferred. Using simulations as well as realistic opportunistic people network scenarios, we demonstrate that the SCIA scheme provides a better web surfing service than traditional schemes, and thus facilitates more effective web surfing on the go.
Biomonitoring with Wireless Communications (2003)

Wireless biomonitoring, first used in human beings for fetal heart-rate monitoring more than 30 years ago, has now become a technology for remote sensing of patients' activity, blood pulse pressure, oxygen saturation, internal pressures, orthopedic device loading, and gastrointestinal endoscopy. Technical advances in miniaturization and wireless communications have enabled development of monitoring devices that can be made available for general use by individuals/patients and caregivers. New methods for short-range wireless communications not encumbered by radio spectrum restrictions (e.g., ultra-wideband) will enable applications of wireless monitoring without interference in ambulatory subjects, in home care, and in hospitals.
Public-Key Encrypted Bloom Filters with Applications to Supply Chain Integrity (2011)

Bloom filters provide a space- and time-efficient mean to check the inclusion of an element in a set. In some applications it is beneficial, if the set represented by the Bloom filter is only revealed to authorized parties. Particularly, operations data in supply chain management can be very sensitive and Bloom filters can be applied to supply chain integrity validation. Despite the protection of the represented set, Bloom filter operations, such as the verification of set inclusion, need to be still feasible. In this paper we present privacy-preserving, publicly verifiable Bloom filters which offer both: privacy for the represented set and public Bloom filter operations. We give security proofs in the standard model.
Detection, separation and recognition of speech from continuous signals using spectral factorisation (2012)

In real world speech processing, the signals are often con-tinuous and consist of momentary segments of speech over non-stationary background noise. It has been demonstrated that spectral factorisation using multi-frame atoms can be suc-cessfully employed to separate and recognise speech in ad-verse conditions. While in previous work full knowledge of utterance endpointing and speaker identity was used for noise modelling and speech recognition, this study proposes spec-tral factorisation and sparse classification techniques to de-tect, identify, separate and recognise speech from a continu-ous noisy input. Speech models are trained beforehand, but noise models are acquired adaptively from the input by us-ing voice activity detection without prior knowledge of noise-only locations. The results are evaluated on the CHiME cor-pus, containing utterances from 34 speakers over highly non-stationary multi-source noise. Index Terms — Spectral factorization, speech recogni-tion, speaker recognition, voice activity detection, speech separation 1.
Dielectric and pyroelectric studies of TGS, TGFB and TGS-TGFB system (1981)

Abstract Dielectric permittivity and pyroelectric coefficient of mixed crystals of TGS and TGFB are reported. It has been shown that L-alanine doped mixed crystals can be good elements for IR detectors.
A multi-function ISDN home communication system (1990)

An integrated services digital network (ISDN)-based home communication system (IHCS) is proposed. It is designed to accommodate the ISDN central office based services as well as the home information products. The architecture, featuring functional message signaling and intelligent station set, allows call processing and feature enhancements. The IHCS architecture adapts to various types of home equipment offered by different vendors and ensures future system expansion. With its expandable messaging capability, the proposed IHCS will provide: a substantial improvement in the control of house functions such as continuous monitoring and surveillance of home security, energy management, and appliance control; enhanced data services, e.g. home automation and interactive information access; and enhanced voice services, e.g. intercom and call management features.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Throughput-optimal random access with order-optimal delay (2011)

In this paper, we consider CSMA policies for scheduling packet transmissions in multihop wireless networks with one-hop traffic. The main contribution of the paper is to propose a novel CSMA policy, called Unlocking CSMA (U-CSMA), that enables to obtain both high throughput and low packet delays in large wireless networks. More precisely, we show that for torus interference graph topologies with one-hop traffic, U-CSMA is throughput optimal and achieves order-optimal delay. For one-hop traffic, the delay performance is defined to be order-optimal if the delay stays bounded as the network-size increases. Simulations that we conducted suggest that (a) U-CSMA is throughput-optimal and achieves order-optimal delay for general geometric interference graphs and (b) that U-CSMA can be combined with congestion control algorithms to maximize the network-wide utility and obtain order-optimal delay. To the best of our knowledge, this is the first time that a simple distributed scheduling policy has been proposed that is both throughput/utility optimal and achieves order-optimal delay.
Second-Mode Tuning Forks for High Frequencies: Finite Element Analysis and Experiments (1980)

Absmcr-Modified tuning forks are considered, with possible applications to second-mode quartz crystal tuning forks having a high effective mechanical quality factor Q, in the 100-6OO-Mlz frequency range. In order to use the quartz crystal tuning fork while maintaining a high Qe, which is inversely proportional to the square of displacements at the support, it is preferable to make a small dimensional modification of the inside arm end of the fork so that the displacements of the base end of the fork are greatly reduced. Some modifications are suggested and their effects proved for a high Q, by calculating the base displacements of tuning forks with use of the fiiite-element method. Calculated results are verified experimentally by measuring Q, of mounted tuning forks proportionately enlarged from the practical quartz tuning forks. In addition, an electrode configuration is shown that will drive the second mode and suppress the unwanted fundamental.
Increased Binding of Concanavalin A to Interferon-Treated Murine Leukemia L 1210 Cells (1974)

Cultivation of mouse lymphoid leukemia L 1210 cells with mouse interferon preparations resulted in an increased binding of radioactive Concanavalin A (Con A). No increase in Con A binding was observed when L 1210 cells were cultivated with control preparations, inactivated mouse interferon preparations, or heterologous interferon preparations, nor when a subline of interferon resistant L 1210 cells was cultivated with mouse interferon. Electron microscopic examination of control or interferon-treated L 1210 cells using peroxidase-labeled Con A showed that all the label was seen at the cell surface. Interferon-treated L1210 cells exhibiting an increased binding of Con A were far less tumorigenic for DBA/2 mice than untreated L 1210 cells. We conclude that interferon treatment of L 1210 cells is accompanied by modifications of the cell surface which can be detected by an increased binding of Con A to the cell surface.