gebhart/patrepeval huggingface dataset:
Antineoplastic Agents, 105. Zephyranthes grandiflora (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntineoplastic Agents, 105. Zephyranthes grandifloraGeorge R. Pettit, Venkatswamy Gaddamidi, and Gordon M. CraggCite this: J. Nat. Prod. 1984, 47, 6, 1018–1020Publication Date (Print):November 1, 1984Publication History Published online1 July 2004Published inissue 1 November 1984https://pubs.acs.org/doi/10.1021/np50036a020https://doi.org/10.1021/np50036a020research-articleACS PublicationsRequest reuse permissionsArticle Views353Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
3.4 A 0.01mm<sup>2</sup> 25µW 2MS/s 74dB-SNDR Continuous-Time Pipelined-SAR ADC with 120fF Input Capacitor (2019)

The kT/C noise poses a fundamental SNR limit for discrete-time (DT) ADCs with front-end sampling operations. To achieve a high resolution, the sampling capacitor needs to be sufficiently large (e.g., 3pF for 80dB SNR assuming 2V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> swing) and it has to be quadrupled for every 1b increase in the resolution. A large sampling capacitor poses critical challenges for both the ADC input buffer and the reference buffer (Fig. 3.4.1). To meet the stringent linearity requirement of high-resolution ADCs, these buffers consume a significant amount of power, which can be comparable or even higher than the ADC itself. In addition, a large capacitor makes it difficult to design the ADC front-end S/H circuit, leading to considerable power/area costs and increased design complexity.
Comparative Pharmacodynamic Analysis of Q-T Interval Prolongation Induced by the Macrolides Clarithromycin, Roxithromycin, and Azithromycin in Rats (2000)

In order to evaluate the arrhythmogenic potency of macrolide antibiotics in a quantitative manner, we analyzed the influence of clarithromycin (CAM), roxithromycin (RXM), and azithromycin (AZM) on Q-T intervals from pharmacokinetic and pharmacodynamic points of view and in comparison with the potency of erythromycin (EM) previously reported by us for rats. Male Sprague-Dawley rats were anesthetized, and CAM (6.6, 21.6, and 43.2 mg/kg of body weight/h), RXM (20 and 40 mg/kg/h), and AZM (40 and 100 mg/kg/h) were intravenously injected for 90 min to obtain the time courses of drug concentrations in plasma and the changes in the Q-T intervals during and after the drug injections. Distinct Q-T interval prolongation of up to 10 ms was observed with CAM at its clinical concentrations. RXM and AZM evoked Q-T interval prolongation at concentrations higher than their clinical ranges. The potencies for Q-T interval prolongation, assessed as the slope of the concentration-response relationship, were 6.09, 0.536, and 0.989 ms. ml/microg for CAM, RXM, and AZM, respectively. There was hysteresis between the change in the Q-T intervals and the time course of the plasma concentration of each drug. The rank order of clinical arrhythmogenicity was estimated to be EM > CAM > RXM > AZM, as assessed from the present results and our previous report for EM. In conclusion, RXM and AZM were estimated to be less potent at provoking arrhythmia than EM and CAM. These results should be useful for making a safer choice of an appropriate agent for patients with electrocardiographic risk factors.
Economics of Product Development by Users: The Impact of 'Sticky' Local Information (1998)

Another version of this paper is available in the Sloan Working Papers collection at https://dspace.mit.edu/handle/1721.1/2712.
Epithelial-to-Mesenchymal Transition and Ovarian Tumor Progression Induced by Tissue Transglutaminase (2009)

Tissue transglutaminase (TG2), an enzyme that catalyzes Ca(2+)-dependent aggregation and polymerization of proteins, is overexpressed in ovarian cancer cells and tumors. We previously reported that TG2 facilitates tumor dissemination using an i.p. xenograft model. Here we show that TG2 modulates epithelial-to-mesenchymal transition (EMT), contributing to increased ovarian cancer cell invasiveness and tumor metastasis. By using stable knockdown and overexpression in epithelial ovarian cancer cells, we show that TG2 induces a mesenchymal phenotype, characterized by cadherin switch and invasive behavior in a Matrigel matrix. This is mediated at the transcriptional level by altering the expression levels and function of several transcriptional repressors, including Zeb1. One mechanism through which TG2 induces Zeb1 is by activating the nuclear factor-kappaB complex. The effects of TG2 on ovarian cancer cell phenotype and invasiveness translate into increased tumor formation and metastasis in vivo, as assessed by an orthotopic ovarian xenograft model. Highly expressed in ovarian tumors, TG2 promotes EMT and enhances ovarian tumor metastasis by activating oncogenic signaling.
Ultrasonic wave-based structural health monitoring embedded instrument (2013)

Piezoelectric sensors and actuators are the bridge between electronic and mechanical systems in structures. This type of sensor is a key element in the integrity monitoring of aeronautic structures, bridges, pressure vessels, wind turbine blades, and gas pipelines. In this paper, an all-in-one system for Structural Health Monitoring (SHM) based on ultrasonic waves is presented, called Phased Array Monitoring for Enhanced Life Assessment. This integrated instrument is able to generate excitation signals that are sent through piezoelectric actuators, acquire the received signals in the piezoelectric sensors, and carry out signal processing to check the health of structures. To accomplish this task, the instrument uses a piezoelectric phased-array transducer that performs the actuation and sensing of the signals. The flexibility and strength of the instrument allow the user to develop and implement a substantial part of the SHM technique using Lamb waves. The entire system is controlled using configuration software and has been validated through functional, electrical loading, mechanical loading, and thermal loading resistance tests.
Activity and therapeutic potential of ORI-1001 antisense oligonucleotide on human papillomavirus replication utilizing a model of dysplastic human epithelium. (2005)

Human Papillomaviruses (HPVs) are small double-stranded DNA viruses that infect the cutaneous or mucosal epithelium. The high-risk genital HPVs are associated with squamous intraepithelial lesions of the anogenital region that can progress to cancer. Cervical cancer is the third leading cause of cancer death in women worldwide, yet there are no specific therapeutic treatments for HPV-associated malignancies. Development of specific antisense oligonucleotides as antiviral agents is an alternative therapeutic strategy. We utilized the organotypic raft culture system which recapitulates the entire HPV life cycle, including the production of infectious virions. We studied the effect of the ORI-1001 antisense phosphorothioate oligonucleotide designed against the E1 mRNA translation start site of low-risk HPV6 and HPV11, and tested it against high-risk HPV31b and HPV16 vegetative replication and oncogene promoter activity. ORI-1001 significantly inhibited HPV31b genome amplification. In contrast, HPV16 genome amplification was unaffected. In addition, ORI-1001 significantly downregulated transcriptional activity from a HPV31b p99 early promoter luciferase reporter construct, and inhibited E1 and E6E7 transcript expression from the wild-type genome. Our results support the idea that the antisense activity of OR-1001 can target HPV31b functional activities in the differentiation dependent life cycle of this virus. Our results predict that binding stability between antisense oligonucleotides with partial homology to HPV genes may mediate targeting of multiple HPV types. Our studies also highlight the utility of the raft culture system in defining the parameters for testing antisense oligonucleotides against HPV.
Taking stock: career planning for isolated, middle‐level professionals (1996)

Middle‐level professionals working in one‐person library or information units, usually women, frequently experience obstacles to career progression, which are seen as insurmountable. Examines some of these obstacles, and suggests a possible approach to career planning incorporating a number of different strategies for change.
How Neuroscience Relates to Hearing Aid Amplification (2014)

Hearing aids are used to improve sound audibility for people with hearing loss, but the ability to make use of the amplified signal, especially in the presence of competing noise, can vary across people. Here we review how neuroscientists, clinicians, and engineers are using various types of physiological information to improve the design and use of hearing aids.
Influence of pH, H2S and Ferrous Ions on Localized Corrosion of Iron by Sulfate-Reducing Bacteria (2006)

Abstract not Available.
Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells (2005)

Macrolide antibiotics decrease proinflammatory cytokine production in airway cells from subjects with chronic airway inflammation. However, in subjects with chronic obstructive pulmonary disease, short-term azithromycin (AZM) therapy causes a transient early increase in the blood neutrophil oxidative burst followed by a decrease in inflammatory markers with longer administration. We studied the effects of clarithromycin (CAM) and AZM on proinflammatory cytokine production from normal human bronchial epithelial (NHBE) cells. CAM decreased IL-8 over the first 6 h and then significantly increased interleukin (IL)-8 at 12-72 h after exposure (P < 0.0001). AZM also increased IL-8 at 24 and 48 h, and CAM increased granulocyte-macrophage colony-stimulating factor at 48 h. In the presence of LPS, both CAM and AZM dose-dependently increased IL-8 secretion over 24 h, but after 5 days of exposure to 10 microg/ml CAM there is suppression of IL-8 (P < 0.001). PD-98059, an inhibitor of MAP kinase/ERK kinase, inhibited CAM-induced IL-8 (P < 0.0001) and GM-CSF (P < 0.01) release. The p38 MAP kinase inhibitor SB-203580 increased CAM-induced IL-8 release (P < 0.001), and the c-jun NH2-terminal kinase inhibitor SP-600125 had no effect on IL-8. At 120 min and 6 h, CAM increased phospho-ERK1/2 (pERK) but not phospho-p38 or phospho-JNK. Over the first 90 min, CAM at 10 microg/ml inhibited pERK and then increased pERK in parallel with measured IL-8 secretion. After daily CAM exposure for 5 days, both IL-8 and pERK returned to baseline. The p38 MAP kinase inhibitor, SB-203580 increased ERK phosphorylation and IL-8 secretion. These results suggest that macrolide antibiotics can differentially modulate proinflammatory cytokine secretion in NHBE cells, in part through ERK.
Hydroxylamine, Oxime and Hydroxamic Acid Derivatives of Nucleic Acids (2010)

Abstract Hydroxylamines directly react with nucleobases in genomic DNA, and the damaged nucleobases induce genetic mutations by forming non‐canonical base pairs with natural bases. In contrast, some nucleoside analogues containing hydroxylamine and its related derivatives are known to possess antiviral and anticancer activities by mimicking natural nucleosides. In addition, oligonucleotides with phosphate backbones modified with hydroxylamines show nuclease resistance required for oligonucleotide therapeutics. This chapter provides the fundamental functions and the applications of hydroxylamine, oxime and hydroxamic acid groups on nucleic acids, consisting of four contents (1. Reactions of hydroxylamine and O ‐methylhydroxylamine with nucleobases, 2. Nucleoside and nucleotide analogues consisting of hydroxylamine, oxime and hydroxamic acid groups, 3. A series of oligonucleotides modified at backbone and sugar moieties with these functional groups, and 4. Application for the detection and quantification of DNA lesions by aminooxy probes). Novel nucleic acids will be developed by understanding potential functions of hydroxylamine and its related derivatives.
Hypoglycemic Effect of a<i>Lentinus edodes</i>Exo-polymer Producedfrom a Submerged Mycelial Culture (2002)

The hypoglycemic effect of an exo-polymer produced from a submerged mycelial culture of Lentinus edodes was investigated in streptozotocin-induced diabetic rats. The administration of the exo-polymer (200 mg/kg BW) reduced the plasma glucose level by as much as 21.5%, and increased plasma insulin by 22.1% as compared to the control group. It also lowered the plasma total cholesterol and triglyceride levels by 25.1 and 44.5%, respectively. Gel chromatography of the exo-polymer revealed a single peak which is likely to have been a glycoprotein with a molecular weight of 52 kDa and was found to contain 83.5% carbohydrate and 16.5% protein. The Sugar and amino acid compositions of the exo-polymer were analyzed in detail.
On the Probability of Error of Antenna-Subset Selection With Space–Time Block Codes (2005)

Orthogonal space-time block codes (OSTBCs) can obtain full diversity advantage with a simple, but optimal, receiver. Unfortunately, OSTBCs lack in array gain compared with beamforming techniques and suffer a rate loss for more than two transmit antennas. One simple method for improving the array gain and adapting OSTBCs to any number of transmit antennas is antenna-subset selection, where the OSTBC is transmitted on a subset of the transmit antennas. In this letter, we analyze the symbol-error rate performance of antenna-subset selection combined with OSTBCs.
X-ray Studies on the Hydrous Oxides. VI. Alumina Hydrates (1934)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTX-ray Studies on the Hydrous Oxides. VI. Alumina HydratesHarry B. WeiserHarry B. WeiserMore by Harry B. Weiser and W. O. MilliganW. O. MilliganMore by W. O. MilliganCite this: J. Phys. Chem. 1934, 38, 9, 1175–1182Publication Date (Print):September 1, 1934Publication History Published online1 May 2002Published inissue 1 September 1934https://doi.org/10.1021/j150360a006RIGHTS & PERMISSIONSArticle Views70Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (363 KB) Get e-Alerts
Molecular strategy for ‘serotyping’ of human enteroviruses (2001)

To explore further the phylogenetic relationships between human enteroviruses and to develop new diagnostic approaches, we designed a pair of generic primers in order to study a 1452 bp genomic fragment (relative to the poliovirus Mahoney genome), including the 3' end of the VP1-coding region, the 2A- and 2B-coding regions, and the 5' moiety of the 2C-coding region. Fifty-nine of the 64 prototype strains and 45 field isolates of various origins, involving 21 serotypes and 6 strains untypable by standard immunological techniques, were successfully amplified with these primers. By determining the nucleotide sequence of the genomic fragment encoding the C-terminal third of the VP1 capsid protein we developed a molecular typing method based on RT-PCR and sequencing. If field isolate sequences were compared to human enterovirus VP1 sequences available in databases, nucleotide identity score was, in each case, highest with the homotypic prototype (74.8 to 89.4%). Phylogenetic trees were generated from alignments of partial VP1 sequences with several phylogeny algorithms. In all cases, the new classification of enteroviruses into five identified species was confirmed and strains of the same serotype were always monophyletic. Analysis of the results confirmed that the 3' third of the VP1-coding sequence contains serotype-specific information and can be used as the basis of an effective and rapid molecular typing method. Furthermore, the amplification of such a long genomic fragment, including non-structural regions, is straightforward and could be used to investigate genome variability and to identify recombination breakpoints or specific attributes of pathogenicity.
Gestational trophoblastic disease. Molecular and genetic studies. (1998)

For a geneticist, the gestational trophoblastic diseases are a particularly interesting group of diseases. Hydatidiform moles were one of the first of a growing number of human disorders shown to result from the phenomenon of genomic imprinting, while gestational trophoblastic tumors are unusual neoplasms in that they derive not from the patients' own tissue but from a genetically distinct pregnancy. We review here the development of our understanding of the genetics of gestational trophoblastic disease and describe how modern molecular genetic techniques can be used to aid in the management of these conditions and further our understanding of their unusual biology.
Characterization of the gene for a protein kinase which phosphorylates the sporulation-regulatory proteins Spo0A and Spo0F of Bacillus subtilis (1989)

The kinA (spoIIJ) locus contains a single gene which codes for a protein of 69,170 daltons showing strong homology to the transmitter kinases of two component regulatory systems. The purified kinase autophosphorylates in the presence of ATP and mediates the transfer of phosphate to the Spo0A and Spo0F sporulation regulatory proteins. Spo0F protein was a much better phosphoreceptor for this kinase than Spo0A protein in vitro. Mutants with deletion mutations in the kinA gene were delayed in their sporulation. They produced about a third as many spores as the wild type in 24 h, but after 72 h on solid medium, the level of spores approximated that found for the wild-type strain. Such mutations had no effect on the regulation of the abrB gene or on the timing of subtilisin expression and therefore did not impair the repression function of the Spo0A protein. Placement of the kinA locus on a multicopy vector suppressed the sporulation-defective phenotype of spo0B, spo0E, and spo0F mutations but not of spo0A mutations. The results suggest that the spo0B-, spo0E-, and spo0F-dependent pathway of activation (phosphorylation) of the Spo0A regulator may be by-passed through the kinA gene product if it is present at sufficiently high intracellular concentration. The results suggest that multiple kinases exist for the Spo0A protein.
Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells (2007)

TGF-beta is a pluripotent cytokine that is capable of inducing the expression of Foxp3 in naive T lymphocytes. TGF-beta-induced cells are phenotypically similar to thymic-derived regulatory T cells in that they are anergic and suppressive. We have examined the cytokine and costimulatory molecule requirements for TGF-beta-mediated induction and maintenance of Foxp3 by CD4(+)Foxp3(-) cells. IL-2 plays a non-redundant role in TGF-beta-induced Foxp3 expression. Other common gamma-chain-utilizing cytokines were unable to induce Foxp3 expression in IL-2-deficient T cells. The role of CD28 in the induction of Foxp3 was solely related to its capacity to enhance the endogenous production of IL-2. Foxp3 expression was stable in vitro and in vivo in the absence of IL-2. As TGF-beta-induced T regulatory cells can be easily grown in vitro, they may prove useful for the treatment of autoimmune diseases, for the prevention of graft rejection, and graft versus host disease.
On the SER analysis of A-law companded OFDM system (2002)

Orthogonal frequency division multiplexing (OFDM) has established itself as a very appealing technique for high-rate data transmission over dispersive channels. The main disadvantage of OFDM is that the signal exhibits Gaussian-like time-domain waveform with high peak-to-average power ratio, which limits the efficiency of the transmitter amplifier and degrades the received signal to noise ratio. The companding technique can be employed to mitigate quantization noise and the peak-to-average-power ratio of OFDM system. The symbol error rate of the companded OFDM systems is investigated. The performances of the systems with and without companding are compared.
Bluetooth Technology: Link Performance and Networking Issues (2001)

Bluetooth has recently obtained an unprecedented success in gaining a wide industry support. The main aim of Bluetooth is to eliminate interconnection cables and to connect one device to another via a universal radio link. First generation Bluetooth chipsets are limited in range to approximately 10 meters under typical line-of-sight conditions. Future implementations will provide roughly ten times that range. In the present paper, a performance assessment of Bluetooth, for both the long range and short range cases, is presented. In particular, the performance of the point-topoint link and the effectiveness of the error correcting codes mentioned in Bluetooth’s specifications will be carried out by means of Monte Carlo simulations. Moreover, some networking issues that may limit Bluetooth applicability in some environments will be pointed out. In addition, piconet throughput analysis is also provided. TM Telcordia is a trademark of Telcordia Technologies, Inc.