gebhart/patrepeval huggingface dataset:
Antibody Response and Tumor Growth in Syngeneic Mice Immunized to Partially Purified B16 Melanoma-Associated Antigens (1978)

Soluble murine melanoma-associated antigens (MAA), partially purified from the media of B16 melanoma cells in culture by ammonium sulfate precipitation and Sephadex G-200 chromatography, were tested for their effect on tumor growth. MAA were immunogenic in syngenic mice as evidenced by their ability to induce anti-melanoma antibodies and partial protective tumor immunity. The level of immunity was variable. It ranged from retardation of tumor development to almost complete suppression of tumor growth. The results were influenced by the nature of the control group, since immunization to either normal tissue antigens or complete Freund's adjuvant enhanced tumor growth. Overall, 46 of 91 MAA immunized mice, but none of 114 control mice, survived over 6 weeks (p less than 0.001). The protective immunity was specific since MAA immunized mice were not resistant to challenge with an unrelated syngeneic tumor (BW 10232 ADENOCARCINOMA). Partially purified normal tissue antigens were also immunogenic in syngeneic mice. They induced low levels of antibodies to, and enhanced the growth of, melanoma. These findings indicate that the culture media of melanoma cells contains tumor antigens that retain their biologic activity after partial purification, and that can induce specific, although only partial, protective immunity to melanoma.
Double conversion tuner: a must for the future? (1992)

A new approach to a tuner technique, the double conversion tuner, is presented, and the test results based on such a concept are shown. The issues considered are problem areas such as IM2, IM3, the noise figure, signal-to-noise ratio at larger RF input signals affected by the automatic gain control (AGC) starting point, local oscillator (LO) phase jitter, beat problems between the LO1 and LO2, and crosstalk between the mixer and the oscillator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Thulium-doped tellurite glasses for S-band amplification (2002)

The advantages of tellurite glass hosts for Tm-doped S-band gain media are investigated. Comparisons are made with fluoride hosts and the ability to control bandwidth. by choice of tellurite glass composition is demonstrated.
[Bronchiolo-alveolar carcinoma complicating systemic scleroderma under long-term treatment with factor XIII]. (1987)

A 52-year old woman with systemic scleroderma had been treated since 1978 with factor XIII. The skin lesions had improved, and respiratory lesions had become stabilized. In 1984, she developed a bronchiolo-alveolar carcinoma which was treated by surgery. The authors emphasize that factor XIII is well tolerated and has beneficial effects on the skin and probably also on the lungs, without tachyphylaxis; however, the possibility of a bronchioloalveolar carcinoma occurring cannot be ruled out.
Gender bias: Representations of work in history museums (1990)

(1990). Gender bias: Representations of work in history museums. Continuum: Vol. 3, Space, Meaning, Politics, pp. 70-83.
Temporal masking for unsupervised minimum Bayes risk speaker adaptation (2007)

The minimum Bayes risk (MBR) criterion has previously been applied to the task of speaker adaptation in large vocabulary continuous speech recognition. The success of unsupervised MBR speaker adaptation, however, has been limited by the accuracy of the estimated transcription of the acoustic data. This paper addresses this issue not by improving the accuracy of the estimated transcription but via temporal masking of its erroneous regions.
Numerical Simulation of Liquid Jet Holding a Cylinder (1998)

Abstract The time-dependent nonlinear problem on a cylinder suspension by a thin inviscid liquid jet is solved numerically. A new conservative free-lagrange method has been applied. The stable oscillating motion of a cylinder was obtained in a range of problem parameters. Keywords: Jetcylindersuspensionfree lagrangenumerical modelling Additional informationNotes on contributorsA. M. FRANK Tel.: +7-3912-444120, Fax: + + 7-3912-439830, e-mail: frank@cc.krascience.rssi.ru
The 1979 Energy Crisis Symposium: Introduction (1980)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Soft nanotubes from amphiphilic ABA triblock macromonomers (2004)

Soft, water-filled polymer nanotubes of several tens of microm in length have been prepared via self-assembly of amphiphilic ABA-triblock macromonomers in aqueous media; the tubes are mechanically and chemically stable and can be loaded with water-soluble substances.
<title>Portable virtual environment generator: InterFACE</title> (1994)

The relationship between people and computers is currently undergoing a rapid transformation. What was once an inert, complex tool is becoming a natural extension of the user. In order to complete the transformation, the computer must become functionally transparent to the user. Ubiquitous computing holds promise toward this end but has severe limitations in terms of installation and upgrade costs. Virtual environment technology provides a viable alternative, if properly implemented, by seamlessly integrating the user's senses with the growing global information network. This paper is an overview of the InterFACE project at Future Vision Technologies, Inc. InterFACE is a new type of computing device which merges portable computing, wireless communications, synthetic environments and telepresence into a wearable package. The technology is introduced in contrast to existing systems in terms of form, flexibility and ease of use and thereby a framework for market justification is formed. The evolution of the system is also described and major application types are detailed.
TNFα‐induced glutathione depletion lies downstream of cPLA<sub>2</sub> in L929 cells (2001)

Both glutathione (GSH) depletion and arachidonic acid (AA) generation have been shown to regulate sphingomyelin (SM) hydrolysis and are known components in tumor necrosis factor alpha (TNFalpha)-induced cell death. In addition, both have hypothesized direct roles in activation of N-sphingomyelinase (SMase); however, it is not known whether these are independent pathways of N-SMase regulation or linked components of a single ordered pathway. This study was aimed at differentiating these possibilities using L929 cells. Depletion of GSH with L-buthionin-(S,R)-sulfoximine (BSO) induced 50% hydrolysis of SM at 12 h. In addition, TNF induced a depletion of GSH, and exogenous addition of GSH blocked TNF-induced SM hydrolysis as well as TNF-induced cell death. Together, these results establish GSH upstream of SM hydrolysis and ceramide generation in L929 cells. We next analyzed the L929 variant, C12, which lacks both cytosolic phospholipase A(2) (cPLA(2)) mRNA and protein, in order to determine the relationship of cPLA(2) and GSH. TNF did not induce a significant drop in GSH levels in the C12 line. On the other hand, AA alone was capable of inducing a 60% depletion of GSH in C12 cells, suggesting that these cells remain responsive to AA distal to the site of cPLA(2). Furthermore, depleting GSH with BSO failed to effect AA release, but caused a drop in SM levels, showing that the defect in these cells was upstream of the GSH drop and SMase activation. When cPLA(2) was restored to the C12 line by expression of the cDNA, the resulting CPL4 cells regained sensitivity to TNF. Treatment of the CPL4 cells with TNF resulted in GSH levels dropping to levels near those of the wild-type L929 cells. These results demonstrate that GSH depletion following TNF treatment in L929 cells is dependent on intact cPLA(2) activity, and suggest a pathway in which activation of cPLA(2) is required for the oxidation and reduction of GSH levels followed by activation of SMases.
Effects of gas distribution on polysilicon etch rate uniformity for a low pressure, high density plasma (1998)

The geometry of low pressure inductively coupled plasma sources is usually considered to be a main factor in determining both the plasma and processing uniformity over large area wafers. We demonstrate experimentally that the gas flow distribution can have a major impact on both the plasma density and etch rate uniformity at low pressures where one might expect diffusion to make gas flow distribution less important. 150 mm polysilicon on oxide wafers were etched in SF6/Ar (1:1) plasmas between 6 and 20 mTorr. Using a single gas inlet produced polysilicon etch rates that varied by 30% along the gas flow direction, but were highly uniform perpendicular to the gas flow direction. A gas distribution ring, on the other hand, produced highly uniform etch rates with variations less than 4% overall using the same source. Langmuir probe measurements of the ion saturation current spatial profiles in argon and SF6 discharges demonstrated significant gradients across the reactor for a single gas inlet with the largest current density near the inlet.
On recording virtual environments (1993)

Documentation is fundamental to science. For virtual reality to be an effective scientific visualization tool, it must be recordable. This position statement outlines the benefits of image-based recording of virtual environments and introduces the VR-VCR, a device for immersive playback of recorded virtual environments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Calgranulin expression and association with the keratinocyte cytoskeleton (1990)

The molecules calgranulin A and B are two intracellular calcium-binding proteins which are expressed by the lesional keratinocytes of inflammatory dermatoses. We have investigated the induction of the calgranulin proteins in an in vitro system and characterized the epidermal form of calgranulin. Using calgranulin-specific monoclonal antibodies, we have shown that these proteins are expressed within the epidermis of skin explants after 12-24 h culture in vitro. The induction of calgranulin-specific staining on culture was prevented, however, by the inclusion of cycloheximide in the culture medium, in sufficient quantities to prevent de novo protein synthesis. Indirect immunofluorescence staining was used to analyse the subcellular localization of the calgranulin proteins. The specific staining pattern with antibodies which recognize the individual calgranulin proteins was retained in detergent insoluble cytoskeletal preparations of epidermis. In Western blotting experiments epidermal calgranulins could be solubilized only by using a urea-based protein extraction buffer. After sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis of the epidermal extracts a single antigen, with a molecular weight of 13.0 kD was detected with the calgranulin-specific antibody MAC 387. The expression of calgranulins, similar to other members of the same protein family, may regulate cytoskeletal changes in skin disease.
An apparatus for the continuous production of triple distilled water (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn apparatus for the continuous production of triple distilled waterJay E. Taylor Cite this: J. Chem. Educ. 1960, 37, 4, 204Publication Date (Print):April 1, 1960Publication History Received3 August 2009Published online1 April 1960Published inissue 1 April 1960https://doi.org/10.1021/ed037p204RIGHTS & PERMISSIONSArticle Views128Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
A comparative study of the cytotoxicity of silver‐based dressings in monolayer cell, tissue explant, and animal models (2007)

Over the past decade, a variety of advanced silver-based dressings have been developed. There are considerable variations in the structure, composition, and silver content of these new preparations. In the present study, we examined five commercially available silver-based dressings (Acticoat, Aquacel Ag, Contreet Foam, PolyMem Silver, Urgotul SSD). We assessed their cytotoxicity in a monolayer cell culture, a tissue explant culture model, and a mouse excisional wound model. The results showed that Acticoat, Aquacel Ag, and Contreet Foam, when pretreated with specific solutes, were likely to produce the most significant cytotoxic effects on both cultured keratinocytes and fibroblasts, while PolyMem Silver and Urgotul SSD demonstrated the least cytotoxicity. The cytotoxicity correlated with the silver released from the dressings as measured by silver concentration in the culture medium. In the tissue explant culture model, in which the epidermal cell proliferation was evaluated, all silver dressings resulted in a significant delay of reepithelialization. In the mouse excisional wound model, Acticoat and Contreet Foam indicated a strong inhibition of wound reepithelialization on the postwounding-day 7. These findings may, in part, explain the clinical observations of delayed wound healing or inhibition of wound epithelialization after the use of certain topical silver dressings. Caution should be exercised in using silver-based dressings in clean superficial wounds such as donor sites and superficial burns and also when cultured cells are being applied to wounds.
Linear Analog Hyperabrupt Varactor Diode Phase Shifters (2005)

Design and performance of analog phase shifters using hyperabrupt varactors with linear phase versus voltage is presented. Phase linearity of 22 degrees per volt +-8 percent was achieved for a 100 degree S-band device with a phase deviation of 1 degree from linearity. At X-band, linear phase control of 270 degrees was achieved. The selection of the varactor diode capacitance versus voltage and matching circuits for linear performance are presented.
Isolation and Detection of Human IgA Using a Streptococcal IgA-Binding Peptide (2002)

Bacterial proteins that bind to the Fc part of IgG have found widespread use in immunology. A similar protein suitable for the isolation and detection of human IgA has not been described. Here, we show that a 50-residue synthetic peptide, designated streptococcal IgA-binding peptide (Sap) and derived from a streptococcal M protein, can be used for single-step affinity purification of human IgA. High affinity binding of IgA required the presence in Sap of a C-terminal cysteine residue, not present in the intact M protein. Passage of human serum through a Sap column caused depletion of >99% of the IgA, and elution of the column allowed quantitative recovery of highly purified IgA, for which the proportions of the IgA1 and IgA2 subclasses were the same as in whole serum. Moreover, immobilized Sap could be used for single-step purification of secretory IgA of both subclasses from human saliva, with a recovery of approximately 45%. The Sap peptide could also be used to specifically detect IgA bound to Ag. Together, these data indicate that Sap is a versatile Fc-binding reagent that may open new possibilities for the characterization of human IgA.
A network architecture for reliable distributed computing (1988)

A reliable distributed environment (RDE) is proposed that is based on an efficient and reliable extension to datagram communications. The concept of coupled relation is introduced to measure the degree to which distributed environments are reliable. View sections, a programming construct that protects against changes in node status (available or not), as support for distributed computing tasks, are presented. Simulation results are given for coupled relations based on different algorithms, node failure rate, recovery rate, message sending rate, and data missing rate to illustrate the behavior of distributed systems constructed using the view section model on top of RDE.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A great potential for using mesh networks in indoor navigation (2016)

Navigation has always been important to people. Thus, it is hard to succeed in navigation without Global Positioning System. Although, Global Positioning System can be efficiently used in outdoor environments the indoor navigation is still in its infancy. Nevertheless, the indoor navigation is one of many open challenges in the 21 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> century that affects to the major technological advances. However, several indoor positioning solutions have been built over the last decade, but they are still neither accurate enough nor inexpensive for consumer use. Therefore, this paper proposes a novel suggestion that should have a great potential for applying mesh technology in the indoor navigation systems in order to improve the accuracy and the computational capabilities of devices.
Oral feedings in the cancer patient (1979)

The importance of maintaining the cancer patient's nutritional status is now recognized as a major part of the medical care. It is necessary for the oncology team to be aware of the psychological and physiological factors that interfere with food acceptance so that the correct food can be offered at the right time in the most palatable form. The oral route is the preferred method of feeding, and nutritional supplements, chosen according to the individual patient's needs, are of great value in assuring an adequate oral intake. Diagnostic tests and therapy are frequent causes of disruption of the meal schedule and the dietary service must be flexible in providing the patient an opportunity to make up for missed meals. Taste disturbance, nausea, vomiting and mucositis caused by therapy may necessitate periods of intravenous hyperalimentation. Food aversions due to therapy can frequently be prevented by avoiding new or unusual foods in the hours before chemotherapy or irradiation. Regular nutrition counseling during clinic visits and/or hospitalization permits diet modification for specific therapeutic needs. The ultimate goal is the prevention of wasting and debilitation due to malnutrition in the cancer patient.
Synthesis and polymerization of polyacrylic esters (1961)

Abstract The method of telomerization has been employed in the synthesis of the telomer homologs of polyacrylate esters with successively increasing degrees of polymerization ( n ) and of telomers differing in the nature of the polyester chain. Compounds have been synthesized of the general formula magnified image where R and R 1 are alkyl or aryl radicals and n = 2, 4, 8, and 20. With changes in ( n ) from 2 to 20 the structural viscosity of the polyacrylate esters increased from 150 to 8000 centistokes (at 20°), the specific gravity from 1.213 to 1.308, and n D 20 from 1.515 to 1.5479. The presence of double bonds in the molecules of the polyacrylate esters synthesixed made it possible to carry out their polymerization (hardening) in the presence of radical chain initiators with the formation of glassy or elastic, insoluble, nonmelting polymers of sufficient thermal stability and endowed with a number of valuable properties so as to be of considerable practical potentiality. The changes in physical properties of the reaction system (gelation, gradual increase in density and finally the formation of a glass structure) in the course of the polymerization beginning from the very early stages (the gelation point is reached at 5–10% conversion) are responsible for a number of specificities in the kinetics of the hardening of polyacrylate esters. Owing to this we undertook a detailed investigation of the polymerization kinetics under widely varying conditions. Polymerization in bulk takes place autocatalytically, since with increasing degree of structuration in the course of polymerization the rate of diffusion of free radical diminished, leading to a decrease in rate of chain termination. The rate of reaction begins to diminish markedly only at large extents of polymerization. A study has been made of the effect of diluting the reaction mixture with an inert solvent, of the initiation rate, nature of the initiating agent, temperature, chemical structure of the initial polyacrylate ester, as well as of the addition of inhibiting agents on the polymerization kinetics. The results obtained have been discussed from the standpoint of the capacity of the system for structuration under the various conditions of reaction. The heats of hardening of the polyacrylate esters with successively increasing distance between their values have been discussed with respect to the reaction mechanism.
Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells (1996)

Cucurbitacin E has been identified by an empiric screening strategy as a sterol with potent growth inhibitory activity in vitro directed against prostate carcinoma explants (IC50 of 7-50 nM in 2- to 6-day exposures). The mechanism of cucurbitacin cytoxicity has not been elucidated previously. In the present study, we observed that cucurbitacin E caused marked disruption of the actin cytoskeleton, and in a series of cucurbitacin analogues, anti-proliferative activity correlated directly with the disruption of the F-actin cytoskeleton. The distribution of vimentin was also altered in cells exposed to cucurbitacin E, as vimentin associated with drug-induced membrane blebs. The appearance of microtubules was unaffected. Western blot analysis of intracellular actin in cells exposed to cucurbitacins and quantitation of rhodamine-phalloidin binding support the hypothesis that cucurbitacin treatment leads to an inappropriate increase in the filamentous or polymerized actin fraction in prostate carcinoma cells. We conclude that cucurbitacins are potent disruptors of cytoskeletal integrity. Prostate carcinoma cells appear notably sensitive to growth inhibition by cucurbitacin E.
An advanced 0.5- mu m CMOS disposable TiN LDD/salicide spacer process (1990)

An advanced 0.5- mu m CMOS technology which features disposable TiN spacers to define both lightly doped drain (LDD) implantation and self-aligned silicided source, drain, and gate regions is discussed. Since the LDD implantation sequences are reversed using the disposable TiN spacers, this process results in CMOS devices with low salicided junction leakage, reduced source/drain lateral diffusion, and shallow phosphorus N/sup -/ and boron P/sup -/ regions for improved short-channel behavior.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>