gebhart/patrepeval huggingface dataset:
Synthesis of some N-arylazole acetamide derivatives and their anticonvulsant and antimicrobial activities. (1994)

Some new N-arylazole acetamide derivatives have been prepared by the reaction of alpha-bromo-N-arylacetamide with imidazole, pyrazole and 1,2,4-triazole. The structures of these compounds have been confirmed by UV, IR, 1H-NMR and elementary analysis. Their anticonvulsant activities were determined by maximal electroshock (MES) and subcutaneous metrazol (Scmet) tests. Most of the compounds showed anticonvulsant activity with significantly low neurotoxicity according to Phase I tests. Compound 6 carrying alpha-naphthyl and 1,2,4-triazole was found active in the MES test with ED50 = 64.9 mg/kg and TD50 = 221.0 mg/kg but it was not active in corneally stimulated rats. Antibacterial and antifungal activities of the compounds were determined against S. aureus, E. coli, P. aeruginosa, C. albicans, C. parapsilosis, C. pseudotropicalis and C. stellatoidea by using the microdilution broth method. Compounds 8 and 10 showed significant activity (MIC < 32 micrograms/ml) against various Candida species.
Real-Time Highway Traffic Condition Assessment Framework Using Vehicle–Infrastructure Integration (VII) With Artificial Intelligence (AI) (2009)

This paper presents a framework for real-time highway traffic condition assessment using vehicle kinetic information, which is likely to be made available from vehicle-infrastructure integration (VII) systems, in which vehicle and infrastructure agents communicate to improve mobility and safety. In the proposed VII framework, the vehicle onboard equipment and roadside units (RSUs) collaboratively work, supported by an artificial intelligence (AI) paradigm, to determine the occurrence and characteristics of an incident. Two AI paradigms are examined: 1) support vector machines (SVMs) and 2) artificial neural networks (ANNs). Each RSU then assesses the traffic condition based on the information from multiple vehicles traveling on its supervised highway segment. As a case study, this paper developed a model of the VII-SVM framework and evaluated its performance in a microscopic traffic simulation environment for a highway network in Spartanburg, SC. The performance of the VII-SVM was compared with the performance of the corresponding VII-ANN framework, and both frameworks were found to be capable of classifying the travel experience using the kinetic data generated by each vehicle. The performance of the VII-SVM framework, in terms of its detection rate, false-alarm rate, and detection times, was also found to be superior to a baseline California-type incident-detection algorithm. Moreover, the framework provided additional information, including an estimate of the incident location and the likely number of lanes blocked, which will be helpful for implementing an appropriate response strategy. The proposed VII-AI framework thus provides a reliable alternative to traditional traffic sensors in assessing traffic conditions.
Interpretation of a dipole shear anisotropy log in a thrust belt setting (1995)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1995Interpretation of a dipole shear anisotropy log in a thrust belt settingAuthors: Michael C. MuellerMichael C. MuellerAmoco Exploration and Production Companyhttps://doi.org/10.1190/1.1887347 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1887347FiguresReferencesRelatedDetailsCited ByPrediction of coal mine water hazards: a case study from the Huainan Coalfield25 January 2019 | Arabian Journal of Geosciences, Vol. 12, No. 3 SEG Technical Program Expanded Abstracts 1995ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1995 Pages: 1566 publication data© 1995 Copyright © 1995 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Michael C. Mueller, (1995), "Interpretation of a dipole shear anisotropy log in a thrust belt setting," SEG Technical Program Expanded Abstracts : 484-487. https://doi.org/10.1190/1.1887347 Plain-Language Summary PDF DownloadLoading ...
Mushroom Response to Postharvest Hyperbaric Storage (1981)

ABSTRACT Vessels suitable for storing mushrooms [ Agaricus bisporus (Lange) Singe] at absolute pressures to 35 atm were constructed from 43 liter (1A) gas cylinders and plumbed for conducting static or continuous‐flow experiments. Neither pressurization nor gradual depressurization over 6 hr injured mushrooms. Pressure did not affect respiration, but significantly reduced moisture loss during storage. Mushrooms depleted O 2 to very low levels and showed high tolerance to CO 2 . Pressure was used to safely increase CO partial pressure (p) 35‐fold. At 0.035p, CO reduced mushroom browning but not respiration. A completely autonomous storage system with CO 2 removal and automatic O 2 , replenishment was developed.
Very, very fast wetting (2002)

Just after formation, optical fibres are wetted stably with acrylate at capillary numbers routinely exceeding 1000. It is hypothesized that this is possible because of dissolution of air into the liquid coating. A lubrication/boundary integral analysis that includes gas diffusion and solubility is developed. It is applied using conservatively estimated solubility and diffusivity coefficients and solutions are found that are consistent with industry practice and with the hypothesis. The results also agree with the claim of Deneka, Kar & Mensah (1988) that the use of high-solubility gases to bathe a wetting line allows significantly greater wetting speeds. The solutions indicate a maximum speed of wetting which increases with gas solubility and with reduction in wetting-channel diameter.
2D pseudo-array using an ultrasonic one channel time-reversal mirror (2005)

Focusing and beam forming is achieved using a time-reversal process and a unique transducer coupled to a solid cavity. This technique allows one to focus acoustic energy anywhere on a 3D domain with a spatio-temporal resolution comparable to a multiple transducer array. We first record the signal emitted by the transducer and detected by a hydrophone needle at a reference point. The signal received is then time-reversed and remitted using the same transducer. At the reference point, one can observe a spatio-temporal recompression. Moreover, it is shown how the experimental Green's functions at the surface of the cavity can be used to control the emitting ultrasonic field. The solid cavity becomes a 2D pseudo-array. A careful study of this phenomenon leads to a better understanding of the resolution of the focusing system; according to diffraction theory, the focal width is no longer dependent on the transducer aperture but on the dimensions of the solid cavity. The signal-to-noise ratio of such a system is then explained by a modal theory and leads to four influencing parameters being defined: frequency bandwidth; number of transducers; cavity geometry; time reversed signal duration. Finally, a one channel inverse filter based on the frequency analysis is defined; its efficiency is compared to the time reversal one and linked to the modal theory.
An Implementation of the Broadband Home Gateway supporting Multi-Channel IPTV Service (2006)

Home Gateway(HG), called residential gateway(RG) in other words, is a device that interconnects various home electronic devices to one another as well as connects these private home network devices to exterior public network. There are various types of digital home services in IP(Internet Protocol)-based home network system; data service, entertainment service, security service, home automation service and so on. Multimedia related service, especially IPTV(Internet Protocol Television) service, is the attractive one to customer in these home network services. In this paper, we show the implementation of the broadband home gateway supporting multi-channel IPTV service. The proposed and implemented home gateway has an architecture that can provide multi-channel, more than three channels, HD(High Definition) class IPTV service with 20Mbps(megabits per second) bandwidth for each channel. For the improved IPTV service using IP multicast, the proposed HG uses Internet Group Multicast Protocol(IGMP) proxy and IGMP snooping protocol. The proposed HG consists of two main components, system processor for NAT(Network Address Translation) processing and system software functions and an L2(Layer 2) Ethernet switch to interface access network and network distribution in intra-home network. The multicast packets for the multi channel IPTV service go from ingress port for access network interface to egress ports for home network directly based on L2 multicast MAC(Medium Access Control) table in L2 Ethernet switch without via the system processor of the HG. This paper specifies in detail the system structure and implementation of hardware, firmware and software for the proposed HG.
Structure of an α-Helical Peptide and Lipopeptide Bound to the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule CD1d (2016)

Mouse CD1d is a nonclassical MHC molecule able to present lipids and glycolipids to a specialized subset of T cells known as natural killer T cells. The antigens presented by CD1d have been shown to cover a broad range of chemical structures and to follow precise rules determining the potency of the antigen in the context of T cell activation. Together with lipids, initial reports suggested that CD1d can also bind and present hydrophobic peptides with (F/W)XX(I/L/M)XXW. However, the exact location of peptide binding and the molecular basis for the required motif are currently unknown. Here we present the crystal structure of the first peptide identified to bind CD1d, p99, and show that it binds in the antigen-binding groove of CD1d in a manner compatible with its presentation to T cell receptors. Interestingly, the peptide adopts an α-helical conformation, which orients the motif residues toward its deep binding groove, therefore explaining the molecular requirements for peptide binding. Moreover, we demonstrate that a lipopeptide version of the same peptide is able to bind CD1d in a similar conformation, identifying another class of molecules binding this antigen-presenting molecule.
An ASIC for Hartmann-Shack wavefront detection (2002)

An analog VLSI circuit facilitating the focal point position detection in a Hartmann-Shack wavefront sensor for optical wavefront measurements is presented. Detecting the lateral deviation of each focal point of the Hartmann-Shack sensor's lens array caused by the partial distortion of the aberrated wavefront within the according lens, the phase information of the light beam can be retrieved. With the future aim of measuring optical distortions of the human eye, the ASIC is optimized to process an optical incident power of 1 nW per focal point. To prevent spatial aliasing of the focal point positions due to the eye's inherent movements during measurement, the signal processing circuits are designed to allow frame repetition rates of wavefront measurement of several hundred hertz. Experimental measurements of optical lenses show the capability of the prototype ASIC of measuring focal point position deviations relating to spherical and cylindrical wavefront aberrations with a dynamic range of /spl plusmn/1 diopters at an accuracy of /spl plusmn/0.15 diopters. The incident power of 1 nW per focal point thereby allows integration periods of 1 ms for position detection.
Current data and strategy in glioblastoma multiforme. (2010)

Glioblastoma multiforme (GBM) or astrocytoma grade IV on WHO classification is the most aggressive and the most frequent of all primary brain tumors. Glioblastoma is multiforme, resistant to therapeutic interventions illustrating the heterogeneity exhibited by this tumor in its every aspect, including clinical presentation, pathology, genetic signature. Current data and treatment strategy in GBM are presented focusing on basic science data and key clinical aspects like surgery, including personal experience; adjuvant modalities: radiotherapy, chemotherapy, but also for experimental approaches. Therapeutic attitude in recurrent GBM is also widely discussed.
The Preparation of Thiophene AppeNded Vinylogous Iminium Salts and Their Application to the Regioselective Synthesis of Thienylpyrimidines and Thienylpyrroles (1994)

The synthesis of two, vinylogous iminium salts, which contain an appended thiophene group, are described along with their conversion to thiophene substituted pyrimidines and pyrroles
Designer's Workbench: The Programmer Environment (1980)

Designer's Workbench, based on the PWB/UNIX <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∗</sup> operating system, is a software system that provides a high level interface to the circuit design aids used within Bell Laboratories. As well as providing a convenient environment for the use of these applications, a primary goal in the design of DWB was to provide a convenient and versatile environment in which programmers could work. This paper describes the objectives that were defined to reach this goal. The approach was to simplify the addition of new capabilities to the system, realizing that a viable design-aids system must be able to expand with the increased demand for and complexity of the applications it supports. We discuss in detail the methods and mechanisms used in the development and implementation of the system. Although some of these are specific to the functions required by DWB, the general philosophies that are emphasized can be applied to provide a programming environment for any software system.
Evaluation of a New Aerodynamic Particle Sizer <sup>®</sup> Spectrometer for Size Distribution Measurements of Solution Metered Dose Inhalers (2003)

The ability of the Model 3320 and newer Model 3321 Aerodynamic Particle Sizer Spectrometer (APS) to make accurate mass-weighted size distribution measurements of solution metered dose inhalers (MDIs) was evaluated. Measurements of experimental HFA-134a beclomethasone dipropionate MDIs were made with both the APS 3320 and APS 3321 and compared to the Andersen Cascade Impactor (ACI). The mass-weighted size distribution measurements from the ACI and APS 3321 agreed well but were very different than the APS 3320 measurements. Evaluation of the APS 3320 size distribution measurements indicated that the presence of a few erroneous particle measurements caused a gross overestimation of the mass median aerodynamic diameter (MMAD) and geometric standard deviation (GSD). When a previously described technique was used to eliminate erroneous particle size measurements from the size distribution calculation, the MMAD and GSD from the APS 3320 agreed well with those from the ACI and APS 3321. The GSD from the APS 3321 and the APS 3320 after a mask was applied were slightly larger than from the ACI. It is believed that both APS instruments slightly underestimate the GSD while the ACI slightly overestimates the GSD. Further experiments were conducted using the APS 3321 to examine the influence of drug concentration and cosolvent level on the size distribution of solution formulation MDIs. The MMAD was shown experimentally and theoretically to be proportional to drug concentration to the one-third power. Cosolvent concentration had minimal influence on MMAD over the range examined. The measurements reported in this paper demonstrate that it is possible to obtain accurate mass-weighted size distribution measurements with the APS 3320 and APS 3321. These instruments allow for accurate size distribution measurements to be made in minutes as opposed to the hours required to conduct and analyze size distribution measurements from cascade impactors.
Resistance and polarization losses in aqueous buffer–membrane electrolytes for water-splitting photoelectrochemical cells (2012)

The recent development of inexpensive catalysts for the oxygen evolution reaction has suggested that efficient photoelectrochemical cells (PECs) might be constructed from terrestrially abundant materials. Because these catalysts operate in aqueous buffer solutions at neutral to slightly basic pH, it is important to consider whether electrolytic cells can have low series loss under these conditions. Water-splitting or fuel-forming PECs will likely require porous separators or electrolyte membranes to separate the cathode products from oxygen produced at the anode. For this reason we analyze the individual potential losses in electrolytic systems of buffer solutions and commercially available anion- and cation-exchange membranes. Potentiometric analysis and pH measurements were employed to measure the potential losses associated with solution resistance, membrane resistance, and pH gradient formation at the current density (25 mA cm−2) expected for efficient PECs. The membrane pH gradient is the most problematic source of loss in these systems, but monoprotic buffers can minimize the pH gradient by diffusion of the neutral acidic or basic form of the buffer across the membrane. These results suggest that water-splitting PECs can be viable with properly chosen membrane–buffer combinations.
The effect of Haemophilus influenzae type b and pneumococcal conjugate vaccines on childhood pneumonia incidence, severe morbidity and mortality (2010)

The findings indicated that radiologically confirmed pneumonia, as a severe morbidity proxy for mortality, provided better estimates for the LiST model of effect of interventions on mortality reduction than did other outcomes evaluated. The LiST model will use this to estimate the pneumonia mortality reduction which might be observed when scaling up Hib and PC conjugate vaccination in the context of an overall package of child health interventions.
Quantitative Trait Loci Analysis for Five Milk Production Traits on Chromosome <i>Six</i> in the Dutch Holstein-Friesian Population (1996)

Twenty Dutch Holstein-Friesian families, with a total of 715 sires, were evaluated in a granddaughter experiment design for marker-QTL associations. Five traits-milk, fat and protein yield and fat and protein percent-were analyzed. Across-family analysis was undertaken using multimarker regression principles. One and two QTL models were fitted. Critical values for the test statistic were calculated empirically by permuting the data. Individual trait distributions of permuted test statistics differed and, thus distributions, had to be calculated for each trait. Experimentwise critical values, which account for evaluating marker-QTL associations on all 29 autosomal-bovine chromosomes and for five traits, were calculated. A QTL for protein percent was identified in one, and two QTL models and was significant at the 1 and 2% level, respectively. Extending the multimarker regression approach to an analysis including two QTL was limited by families not being informative at all markers, which resulted in singularity. Below average heterozygosity for the first and last marker lowered information content for the first and last marker bracket. Highly informative markers at the ends of the mapped chromosome would overcome the decrease in information content in the first and last marker bracket and singularity for the two QTL model.
Role of thyroid hormones in human and laboratory animal reproductive health (2003)

The highly conserved nature of the thyroid gland and the thyroid system among mammalian species suggests it is critical to species survival. Studies show the thyroid system plays a critical role in the development of several organ systems, including the reproductive tract. Despite its highly conserved nature, the thyroid system can have widely different effects on reproduction and reproductive tract development in different species. The present review focuses on assessing the role of thyroid hormones in human reproduction and reproductive tract development and comparing it to the role of thyroid hormones in laboratory animal reproduction and reproductive tract development. The review also assesses the effects of thyroid dysfunction on reproductive tract development and function in humans and laboratory animals. Consideration of such information is important in designing, conducting, and interpreting studies to assess the potential effects of thyroid toxicants on reproduction and development.
Surface roughness of stainless-steel mirrors for focusing soft x rays (2006)

We have used polished stainless steel as a mirror substrate to provide focusing of soft x rays in grazing-incidence reflection. The critical issue of the quality of the steel surface, polished and coated with gold, is discussed in detail. A comparison is made to a polished, gold-coated, electroless nickel surface, which provides a smoother finish. We used the surface height distributions, measured with an interferometric microscope and complemented by atomic-force microscope measurements, to compute power spectral densities and then to evaluate the surface roughness. The effects of roughness in reducing the specular reflectivity were verified by soft-x-ray measurements.
Anabaptist genealogy database (2003)

In late 1996 we set out to build a computer-searchable genealogy of the Old Order Amish of Lancaster County, Pennsylvania, for use by geneticists. The goals of the project included: 1) using the genealogy to expedite the mapping of genes mutated in three rare recessive disorders under study at the National Institutes of Health (NIH); 2) building a freely available software package, PedHunter, to answer genetically relevant queries on our database and other similar databases; and 3) providing genealogy assistance to researchers outside NIH. All of these scientific goals had to be accomplished while maintaining the confidentiality of the persons in the database and the confidentiality of preliminary research results. We expanded the project to include complementary data sources that contained many individuals who were Anabaptist, but not Amish, and many individuals who never lived in Lancaster County. For this reason, the project was renamed Anabaptist Genealogy Database (AGDB). All of the initial goals of the project have been accomplished, and we recently marked the 5-year anniversary of answering the first of over 100 queries by researchers outside NIH. Thus, it is an opportune time to review the construction of AGDB, summarize its usage to date, and speculate on future projects it might stimulate and facilitate.