gebhart/patrepeval huggingface dataset:
Mortalidad por infarto del miocardio en Guantánamo (2001)

Se realiza un estudio analitico con el objetivo de precisar  aspectos relacionados con los fallecidos por infarto agudo del miocardio (IMA) durante los anos 1991 – 1998 (n = 1011) en Guantanamo. Se establece una panoramica de la magnitud del problema en la provincia, y se reflexiona sobre su comportamiento en el Hospital ¨Dr. Agostinho Neto¨. Se analizan las  causas directas y complementarias de muerte y se valora la influencia de variables de interes en esta mortalidad, (edad, sexo, localizacion y tamano del infarto e indice pronostico de Peel). Se concluye que la letalidad es superior en aquellos con 60 - 69 anos, en hombres, con infarto anterior y con area de infarto superior al 40 % o indice de Peel mayor de 16 puntos. Las fundamentales causas directas y complementarias de muerte son la fibrilacion ventricular primaria y la disfuncion ventricular isquemica, respectivamente. En general, se clasifican las causas directas de muerte como evitables (94,7%). Se establecen otras consideraciones.
Face verification using adapted generative models (2004)

It has been shown previously that systems based on local features and relatively complex generative models, namely 1D hidden Markov models (HMMs) and pseudo-2D HMMs, are suitable for face recognition (here we mean both identification and verification). Recently a simpler generative model, namely the Gaussian mixture model (GMM), was also shown to perform well. In this paper we first propose to increase the performance of the GMM approach (without sacrificing its simplicity) through the use of local features with embedded positional information; we show that the performance obtained is comparable to 1D HMMs. Secondly, we evaluate different training techniques for both GMM and HMM based systems. We show that the traditionally used maximum likelihood (ML) training approach has problems estimating robust model parameters when there is only a few training images available; we propose to tackle this problem through the use of maximum a posteriori (MAP) training, where the lack of data problem can be effectively circumvented; we show that models estimated with MAP are significantly more robust and are able to generalize to adverse conditions present in the BANCA database.
Regulation of basement membrane heparan sulfate proteoglycan, perlecan, gene expression in glomerular epithelial cells by high glucose medium (1996)

Proteinuria in diabetic nephropathy has been correlated with reduction in heparan sulfate proteoglycan (HSPG) content of the glomerular basement membrane. We have previously shown that the underlying mechanism probably involves reduction in the synthesis by glomerular epithelial cells. In this study we explored whether high glucose medium regulates basement membrane HSPG gene expression. Northern analysis demonstrated that rat glomerular epithelial cells in vitro constitutively express mRNA for basement membrane HSPG, similar to that observed in rat kidney glomerulus. RNase protection assay showed that incubation of glomerular epithelial cells with 30 mM glucose for 24 h and 7 days resulted in reduction in HSPG mRNA abundance. The decrease in mRNA abundance correlated with reduction in the synthesis of 35SO4-labeled basement membrane HSPG as measured by immunoprecipitation. Reduction in synthesis of HSPG could not be entirely accounted for by decrease in mRNA abundance, suggesting both transcriptional and posttranscriptional mechanisms may be involved in reduction of glomerular basement membrane HSPG synthesis by glomerular epithelial cells in diabetic nephropathy.
Role of the Seeding Promoter in MoS<sub>2</sub> Growth by Chemical Vapor Deposition (2014)

The thinnest semiconductor, molybdenum disulfide (MoS2) monolayer, exhibits promising prospects in the applications of optoelectronics and valleytronics. A uniform and highly crystalline MoS2 monolayer in a large area is highly desirable for both fundamental studies and substantial applications. Here, utilizing various aromatic molecules as seeding promoters, a large-area, highly crystalline, and uniform MoS2 monolayer was achieved with chemical vapor deposition (CVD) at a relatively low growth temperature (650 °C). The dependence of the growth results on the seed concentration and on the use of different seeding promoters is further investigated. It is also found that an optimized concentration of seed molecules is helpful for the nucleation of the MoS2. The newly identified seed molecules can be easily deposited on various substrates and allows the direct growth of monolayer MoS2 on Au, hexagonal boron nitride (h-BN), and graphene to achieve various hybrid structures.
Gene Transfer to Freshly Isolated Human Respiratory Epithelial Cells <i>In Vitro</i> Using a Replication-Deficient Adenovirus Containing the Human Cystic Fibrosis Transmembrane Conductance Regulator cDNA (1994)

Cystic fibrosis (CF) results from mutations of the CF transmembrane conductance regulator (CFTR) gene and subsequent defective regulation of cAMP-stimulated chloride (Cl-) permeability across the apical membrane of epithelial cells. In vitro transfer of normal CFTR cDNA corrects this defect, and studies in experimental animals have shown successful gene transfer to airway epithelium in vivo using a recombinant adenoviral vector containing the human CFTR cDNA (AdCFTR), supporting the feasibility of in vivo AdCFTR-mediated gene therapy for the respiratory manifestations of CF. One step in applying this therapy to CF patients is to evaluate the safety and efficacy of AdCFTR-mediated gene transfer in the actual target for human gene therapy, human airway epithelium. The present study demonstrates that AdCFTR restores cAMP-stimulated Cl- permeability in human CF bronchial epithelial cells. In addition, the study utilizes freshly isolated human airway epithelial cells from the nose and/or bronchi of normal individuals and/or individuals with CF to demonstrate that after in vitro AdCFTR-mediated gene transfer: (i) AdCFTR DNA does not replicate as a function of dose and time; (ii) CF epithelial cells express AdCFTR-mediated normal human CFTR mRNA; and (iii) CF epithelial cells, including terminally differentiated ciliated cells (the most common airway epithelial cell type), express the normal human CFTR protein. Together, these data support the use of AdCFTR in human gene therapy trials and suggest that biologic efficacy should be achievable in vivo.
Coordinated Control and Energy Management of Distributed Generation Inverters in a Microgrid (2013)

This paper presents a microgrid consisting of different distributed generation (DG) units that are connected to the distribution grid. An energy-management algorithm is implemented to coordinate the operations of the different DG units in the microgrid for grid-connected and islanded operations. The proposed microgrid consists of a photovoltaic (PV) array which functions as the primary generation unit of the microgrid and a proton-exchange membrane fuel cell to supplement the variability in the power generated by the PV array. A lithium-ion storage battery is incorporated into the microgrid to mitigate peak demands during grid-connected operation and to compensate for any shortage in the generated power during islanded operation. The control design for the DG inverters employs a new model predictive control algorithm which enables faster computational time for large power systems by optimizing the steady-state and the transient control problems separately. The design concept is verified through various test scenarios to demonstrate the operational capability of the proposed microgrid, and the obtained results are discussed.
EF6265, a novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor, protects against sepsis-induced organ dysfunction in rats* (2009)

These results clearly suggest that TAFI plays an important role in the deterioration of organ dysfunction in sepsis and the inhibitor of TAFIa protects against sepsis-induced tissue damage through regulation of fibrinolysis and inflammation.
TOTAL INVERSE SOLUTIONS FOR THE GEODESIC AND GREAT ELLIPTIC (1996)

The inverse problem for all possible geodesics on the spheroid is solved in ways that are selected by the programme in a manner appropriate to any two given end positions. The comparatively simple total inverse solution for the great elliptic is also given.
Vortex formation in magnetic narrow rings: The role of magneto-crystalline anisotropy (2001)

Hysteresis loops in mesoscopic narrow rings with cubic anisotropy have been computed. A two-step switching process is found. The first transition corresponds to vortex formation and has been studied in detail. Starting from a well defined remanent state with two opposite head-to-head walls, the vortex is created when, due to any asymmetry, one wall depins first, propagates, reaches the other and they annihilate one another. It is also found that, in this geometry, the crystallographic hard axis becomes the global easy axis due to the combined action of the magneto-crystalline anisotropy and the magnetostatic dipolar fields.
A policy based framework for governing Future networks (2012)

Future Internet will constitute a complex and dynamic environment, the requirements of which cannot be handled by traditional management schemes. The alternative is the approach of autonomic service and network management, which targets at guidance and orchestration of the behavior of autonomic and contemporary network entities based on specific service requirements and business goals. In this context, policies can constitute a means for accomplishing the desired high level control in autonomic management. In order to achieve this objective, an advanced policy framework, confronting the challenges of the highly miscellaneous, decentralized and dynamic Future Internet, is needed. To this effect, this paper presents the main challenges of policy-based management in the context of governing the autonomic Future Internet, and based on their elaboration, the focus is placed on existing concepts that can constitute the basis for the design of a proper policy management framework. The paper also describes the functional specification of the policy management framework, deriving from the presented challenges, and instantiation of the policy framework on an illustrative scenario.
Cutting Edge: Nonglycosidic CD1d Lipid Ligands Activate Human and Murine Invariant NKT Cells (2008)

Invariant NKT cells (iNKT cells) recognize CD1d/glycolipid complexes. We demonstrate that the nonglycosidic compound threitolceramide efficiently activates iNKT cells, resulting in dendritic cell (DC) maturation and the priming of Ag-specific T and B cells. Threitolceramide-pulsed DCs are more resistant to iNKT cell-dependent lysis than alpha-galactosylceramide-pulsed DCs due to the weaker affinity of the human iNKT TCR for CD1d/ threitolceramide than CD1d/alpha-galactosylceramide complexes. iNKT cells stimulated with threitolceramide also recover more quickly from activation-induced anergy. Kinetic and functional experiments showed that shortening or lengthening the threitol moiety by one hydroxymethylene group modulates ligand recognition, as human and murine iNKT cells recognize glycerolceramide and arabinitolceramide differentially. Our data broaden the range of potential iNKT cell agonists. The ability of these compounds to assist the priming of Ag-specific immune responses while minimizing iNKT cell-dependent DC lysis makes them attractive adjuvants for vaccination strategies.
Kinetics of Manganese Lipoxygenase with a Catalytic Mononuclear Redox Center (2000)

Manganese lipoxygenase was isolated from the take-all fungus, Gaeumannomyces graminis, and the oxygenation mechanism was investigated. A kinetic isotope effect, k(H)/k(D) = 21-24, was observed with [U-(2)H]linoleic acid as a substrate. The relative biosynthesis of (11S)-hydroperoxylinoleate (11S-HPODE) and (13R)-hydroperoxylinoleate (13R-HPODE) was pH-dependent and changed by [U-(2)H]linoleic acid. Stopped-flow kinetic traces of linoleic and alpha-linolenic acids indicated catalytic lag times of approximately 45 ms, which were followed by bursts of enzyme activity for approximately 60 ms and then by steady state (k(cat) approximately 26 and approximately 47 s(-1), respectively). 11S-HPODE was isomerized by manganese lipoxygenase to 13R-HPODE and formed from linoleic acid at the same rates (k(cat) 7-9 s(-1)). Catalysis was accompanied by collisional quenching of the long wavelength fluorescence (640-685 nm) by fatty acid substrates and 13R-HPODE. Electron paramagnetic resonance (EPR) of native manganese lipoxygenase showed weak 6-fold hyperfine splitting superimposed on a broad resonance indicating two populations of Mn(II) bound to protein. The addition of linoleic acid decreased both components, and denaturation of the lipoxygenase liberated approximately 0.8 Mn(2+) atoms/lipoxygenase molecule. These observations are consistent with a mononuclear Mn(II) center in the native state, which is converted during catalysis to an EPR silent Mn(III) state. We propose that manganese lipoxygenase has kinetic and redox properties similar to iron lipoxygenases.
Effect of acetyl groups on enzymatic hydrolysis of cellulosic substrates (2006)

Abstract Evidence showed that acetyl groups introduced during acetic acid delignification was a primary cause of the poor enzymatic digestibility of acetic acid pulp. The inhibition by acetyl groups could be removed by saponification. Acetyl groups might inhibit the enzymes by interfering with the productive binding (hydrogen bonds) between cellulose and the catalytic domain of cellulases, by affecting the binding of CBD to cellulose, or by increasing the diameter of the cellulose chain.
Rational Design and Assembly of a New Series of Cyanide-Bridged Fe<sup>III</sup>−Mn<sup>II</sup>One-Dimensional Single Chain Complexes: Synthesis, Crystal Structures, and Magnetic Properties (2009)

Two mononuclear seven-coordinated macrocycle manganese(II) compounds and three dicyanide-containing precursors have been employed as building blocks to assemble cyanide-bridged heterobimetallic complexes, resulting in five new cyanide-bridged single chain complexes {[Mn(L(1))][Fe(bpb)(CN)(2)]}ClO(4) x 0.5 H(2)O (2), {[Mn(L(2))][Fe(bpb)(CN)(2)]}ClO(4) x 0.5 H(2)O (3), {[Mn(L(1))][Fe(bpClb)(CN)(2)]}ClO(4) x H(2)O (4), {[Mn(L(2))][Fe(bpClb)(CN)(2)]}ClO(4) x 0.5 H(2)O (5), and {[Mn(L(1))][Fe(bpdBrb)(CN)(2)]}ClO(4) x H(2)O (6). Single X-ray diffraction analysis reveals their one-dimensional (1D) single cyanide-bridged cationic polymeric chain structure consisting of alternating units of [Mn(L)](2+) (L = L(1) or L(2)) and [Fe(L')(CN)(2)](-) (L' = bpb(2-), bpClb(2-) or bpdBrb(2-)) with free ClO(4)(-) as balanced anion. Similar to the mononuclear macrocyclic manganese(II) precursor {[Mn(L(2))(H(2)O)Cl]ClO(4)}.CH(3)OH (1), the coordination geometry of manganese(II) ion in all the 1D complexes is a slightly distorted pentagonal-bipyrimidal with two cyanide nitrogen atoms at the trans positions and N(5) or N(3)O(2) coordinating mode at the equatorial plane from ligand L(1) or L(2). Investigation of the magnetic properties of these five 1D single chain cyanide-bridged Fe(III)-Mn(II) complexes reveals the antiferromagnetic magnetic coupling between neighboring Fe(III) and Mn(II) ions through the bridging cyanide group. A best-fit to the magnetic susceptibilities of these complexes based on the 1D alternating chain model leads to the magnetic coupling constants J(1) = -1.16(2) and J(2) = -0.10(3) cm(-1) for 2, J(1) = -3.10(1) and J(2) = -0.25(1) cm(-1) for 3, J(1) = -1.10(1) and J(2) = -0.139(8) cm(-1) for 4, J(1) = -1.99(6) and J(2) = -0.57(1) cm(-1) for 5, and J(1) = -1.23(1) and J(2) = -0.13(5) cm(-1) for 6, respectively. This work will provide valuable information for the rational design and synthesis of low-dimensional, in particular, single chain, cyanide-bridged magnetic complexes.
Measurements of Beam Divergence of Q-Switched Ruby Laser Rods (1967)

A method of measuring beam divergence is reported that provides simultaneous variable intensity multiple exposures of the laser output on Polaroid film, and does not require densitometer tracings of the exposures to establish the beam divergence. Using this technique, beam divergence as a function of power output of 12 ``Q-switched'' ruby rods is reported. Inference is made that the active divergence of a ruby rod is the sum of the passive beam divergence of that rod plus the divergence due to radial mode structure. Thermal distortion probably contributes very little to the beam divergence.
Multidirmensional gas chromatography – isotope ratio mass spectrometry (MDGC‐IRMS). Part A: System description and technical requirements (1992)

Abstract A system is presented which combines multidimensional GC with isotope ratio mass spectrometry. The performance of the system is demonstrated with an application from the field of flavor analysis. Potentials and limitations of the technique are also discussed.
The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers (2013)

Histone H3 lysine 4 (H3K4) can be mono-, di-, and trimethylated by members of the COMPASS (complex of proteins associated with Set1) family from Saccharomyces cerevisiae to humans, and these modifications can be found at distinct regions of the genome. Monomethylation of histone H3K4 (H3K4me1) is relatively more enriched at metazoan enhancer regions compared to trimethylated histone H3K4 (H3K4me3), which is enriched at transcription start sites in all eukaryotes. Our recent studies of Drosophila melanogaster demonstrated that the Trithorax-related (Trr) branch of the COMPASS family regulates enhancer activity and is responsible for the implementation of H3K4me1 at these regions. There are six COMPASS family members in mammals, two of which, MLL3 (GeneID 58508) and MLL4 (GeneID 8085), are most closely related to Drosophila Trr. Here, we use chromatin immunoprecipitation-sequencing (ChIP-seq) of this class of COMPASS family members in both human HCT116 cells and mouse embryonic stem cells and find that MLL4 is preferentially found at enhancer regions. MLL3 and MLL4 are frequently mutated in cancer, and indeed, the widely used HCT116 cancer cell line contains inactivating mutations in the MLL3 gene. Using HCT116 cells in which MLL4 has also been knocked out, we demonstrate that MLL3 and MLL4 are major regulators of H3K4me1 in these cells, with the greatest loss of monomethylation at enhancer regions. Moreover, we find a redundant role between Mll3 (GeneID 231051) and Mll4 (GeneID 381022) in enhancer H3K4 monomethylation in mouse embryonic fibroblast (MEF) cells. These findings suggest that mammalian MLL3 and MLL4 function in the regulation of enhancer activity and that mutations of MLL3 and MLL4 that are found in cancers could exert their properties through malfunction of these Trr/MLL3/MLL4-specific (Trrific) enhancers.
Maintaining a Reputation Against A Long-Lived Opponent (1993)

The authors are grateful for financial support from NSF Grants SBR-9223320, SBR-9223175,\n\t\t\t\t SBR-9409180, DGICYT PB92-0245, Human Capital Mobility Programme ERBCHBICT940975, and\n\t\t\t\t the VCLA Academic Senate
A low-cost, optical feedback laser range-finder with chirp-control (2002)

A new laser range finder using optical feedback interferometry and wavelength sweep has been developed. Our aim was to design a high-accuracy sensor for operation on short distances, using a low-cost Mach-Zender interferometer to separately measure the chirp of the laser. Experimentally, on a plain diffusing target, at a 10-cm distance, we were able to demonstrate an accuracy of 100 /spl mu/m. Projected accuracy is down to 20-50 /spl mu/m.
Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta [Erratum to document cited in CA113(9):75187b] (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleDiscodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta [Erratum to document cited in CA113(9):75187b]Sarath P. Gunasekera, Malika Gunasekera, Ross E. Longley, and Gayle K. SchulteCite this: J. Org. Chem. 1991, 56, 3, 1346Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/jo00003a090https://doi.org/10.1021/jo00003a090research-articleACS PublicationsRequest reuse permissionsArticle Views204Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Advanced Laser Imaging Diagnostics in Combustion (2005)

Abstract Laser-based imaging diagnostics allow the quantitative determination of scalar fields (concentrations, temperature) in combustion environments. Beyond instantaneous two-dimensional distributions, multi-dimensional imaging can provide simultaneous information about concentration of more than one species and temperature, about three-dimensional concentration and temperature distributions as well as the temporal evolution of reactions, flows and evaporation processes. Various examples in combustion environments are presented.
Optimal Electrode Configurations for External Cardiac Pacing and Defibrillation: An Inhomogeneous Study (1987)

We have developed an inhomogeneous two-dimensional finite element computer model of the human torso, and have used it to study electrode performance in defibrillation and external cardiac pacing. Gross individual organ effects were assessed first for different electrode configurations by creating models which included one organ at a time, and comparing the results to those obtained with a homogeneous body. Electrode placement on the body was varied in order to determine, within the limitations of the model, optimal electrode configurations for external cardiac pacing and defibrillation. Finally, the electrical and geometric parameters of a previously proposed plate electrode design were optimized for the selected external pacing position. It was found that organs of extreme resistivity, close to the body surface, and within the direct current path between two electrodes, tended to have dominant effects on the surface current density distributions. The optimum pacing position is to place the driven electrode directly over the heart and the receiving electrode on the left lateral chest wall. For defibrillation, the driven electrode is moved to the right of the sternum.
Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa‐2 cell line (1985)

A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line (MIA PaCa-2). Binding of somatostatin to this membrane receptor activates dephosphorylation of a phosphotyrosyl-membrane protein whose phosphorylation was promoted by epidermal growth factor (EGF). Vanadate, a purported inhibitor of dephosphorylation, interferes with the action of somatostatin. These findings suggest a possible biochemical mechanism by which somatostatin may inhibit the growth of human pancreatic cancers.