gebhart/patrepeval huggingface dataset:
Antiinflammatory actions of inorganic nitrate stabilize the atherosclerotic plaque (2017)

Reduced bioavailable nitric oxide (NO) plays a key role in the enhanced leukocyte recruitment reflective of systemic inflammation thought to precede and underlie atherosclerotic plaque formation and instability. Recent evidence demonstrates that inorganic nitrate (NO<sub>3</sub><sup>-</sup>) through sequential chemical reduction in vivo provides a source of NO that exerts beneficial effects upon the cardiovascular system, including reductions in inflammatory responses. We tested whether the antiinflammatory effects of inorganic nitrate might prove useful in ameliorating atherosclerotic disease in Apolipoprotein (Apo)E knockout (KO) mice. We show that dietary nitrate treatment, although having no effect upon total plaque area, caused a reduction in macrophage accumulation and an elevation in smooth muscle accumulation within atherosclerotic plaques of ApoE KO mice, suggesting plaque stabilization. We also show that in nitrate-fed mice there is reduced systemic leukocyte rolling and adherence, circulating neutrophil numbers, neutrophil CD11b expression, and myeloperoxidase activity compared with wild-type littermates. Moreover, we show in both the ApoE KO mice and using an acute model of inflammation that this effect upon neutrophils results in consequent reductions in inflammatory monocyte expression that is associated with elevations of the antiinflammatory cytokine interleukin (IL)-10. In summary, we demonstrate that inorganic nitrate suppresses acute and chronic inflammation by targeting neutrophil recruitment and that this effect, at least in part, results in consequent reductions in the inflammatory status of atheromatous plaque, and suggest that this effect may have clinical utility in the prophylaxis of inflammatory atherosclerotic disease.
A PAF antagonist blocks antigen-induced airway hyperresponsiveness and inflammation in sheep (1989)

We studied the effects of WEB-2086, a specific antagonist of platelet-activating factor (PAF), on the development of antigen-induced airway hyperresponsiveness and inflammation in sheep (n = 8). For these studies, airway responsiveness was determined from slopes of carbachol dose-response curves (DRC) performed at base line (prechallenge) and 2 h after Ascaris suum antigen challenges in the following three protocols: 1) antigen challenge alone (control trial), 2) WEB-2086 (1 mg/kg iv) given 30 min before antigen challenge (WEB pretreatment), and 3) WEB-2086 given 2 h after antigen challenge, immediately before the postchallenge DRC (WEB posttreatment). Airway inflammation was assessed by bronchoalveolar lavage (BAL) before antigen challenge and after the postchallenge DRC for each trial. A. suum challenge resulted in acute increases in specific lung resistance that were not different among the three trials. Antigen challenge (control trial) caused a 93% increase (P less than 0.05) in the slope of the carbachol DRC when compared with the prechallenge value. WEB pretreatment (1 mg/kg) reduced (P less than 0.05) this antigen-induced hyperresponsiveness, whereas pretreatment with a 3-mg/kg dose completely prevented it. WEB posttreatment was ineffective in blocking this hyperresponsiveness. BAL neutrophils increased after antigen challenge in the control trial and when WEB-2086 was given after antigen challenge (P less than 0.05). Pretreatment with WEB-2086 (1 or 3 mg/kg) prevented this neutrophilia. This study provides indirect evidence for antigen-induced PAF release in vivo and for a role of endogenous PAF in the modulation of airway responsiveness and airway inflammation after antigen-induced bronchoconstriction in sheep.
Lieu et intentionnalité (2005)

L’intentionnalité n’est pas la subjectivité, elle est une visée de conscience, une idée adaptée à un projet. Elle convie à penser l’action comme un moyen de donner suite dans la réalité à l’idée qu’une personne ou un groupe de personnes se fait de sa raison d’être dans un contexte social et culturel donné. L’intérêt d’une telle approche pour la géographie est qu’elle nous permet de sortir d’un débat stérile entre la géographie culturelle et la géographie sociale. L’intentionnalité n’est en de...
On giving up on the mental health system (2000)

This chapter describes how the author, who at the time was a practicing psychologist, became personally involved in advocacy for persons with mental illness. He also gives an overview of the activities of several organizations that are, or should be, advocating for this vulnerable population. He describes several specific programs that he sees as exemplary. Finally, the author argues for an approach for improving care, which he feels family and consumer advocates can be particularly effective in implementing.
Preparation and properties of phenyl carbamates with phosphoryl and carbamyl substituents (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and properties of phenyl carbamates with phosphoryl and carbamyl substituentsBogumil Hetnarski and Richard D. O'BrienCite this: J. Agric. Food Chem. 1972, 20, 3, 543–546Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://pubs.acs.org/doi/10.1021/jf60181a055https://doi.org/10.1021/jf60181a055research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[A case of gall bladder cancer with high level alpha-fetoprotein]. (1989)

A case of primary gall bladder tumor with high level AFP were demonstrated, which showed hepatocellular carcinoma like pattern with trabecular proliferation histologically, positive AFP stain of cancer cells by a peroxidase conjugated antibody method immunohistochemically. This case was no metastasis with liver and lymph nodes.
FFT scaling in Domino CMOS gates (1985)

The switching delay of a Domino CMOS gate can be reduced by up to 30% by scaling the NFET chain so that th FET closest to the ground is the largest, with FET size decreasing monotonically from ground to output. The technique is most effective when applied to complex gates, such as those found in a carry look-ahead circuit. The same technique has application to other MOS circuits including NMOS circuits.
Crowd creativity through combination (2011)

The goal of this research is to perform large-scale experiments to see if the crowd, mediated by technology, produces creative designs by combining designs. To fulfill this goal, a sequential combination system is built. The system is a variant on a human based genetic algorithm, through which the crowd participates in an iterative process of design, evaluation, and combination. The study will provide a way of creatively solving problems in a number of different domains. It will also shed light on the mechanisms of social creativity: how individuals can build on each other's work and how technology can facilitate design by encouraging collaboration through shared designs.
A simple guide to determine elastic properties of films on substrate from nanoindentation experiments (2007)

This submission has been removed by arXiv administration because it was submitted in violation of copyright by HAL.
Reconstitution of the Myxothiazol Biosynthetic Gene Cluster by Red/ET Recombination and Heterologous Expression in <i>Myxococcus xanthus</i> (2006)

Although many secondary metabolites exhibiting important pharmaceutical and agrochemical activities have been isolated from myxobacteria, most of these microorganisms remain difficult to handle genetically. To utilize their metabolic potential, heterologous expression methodologies are currently being developed. Here, the Red/ET recombination technology was used to perform all required gene cluster engineering steps in Escherichia coli prior to the transfer into the chromosome of the heterologous host. We describe the integration of the complete 57-kbp myxothiazol biosynthetic gene cluster reconstituted from two cosmids from a cosmid library of the myxobacterium Stigmatella aurantiaca DW4-3/1 into the chromosome of the thus far best-characterized myxobacterium, Myxococcus xanthus, in one step. The successful integration and expression of the myxothiazol biosynthetic genes in M. xanthus results in the production of myxothiazol in yields comparable to the natural producer strain.
Multiple search engines in database merging (1997)

A database merging technique is a strategy for combining the results of multiple independent searches into a single cohesive response. While a variety of techniques have been developed to address a range of problem characteristics, our work focuses on environments in which search engines work in isolation. This paper shows that the behavior of two previously developed isolated techniques is indeed independent of the particular search engines that participate in the search. Two very different search engines, SMART and TOPIC@, were each used to retrieve documents from five subcollections. The relative effectiveness of the merged result compared to the effectiveness of a corresponding single collection run is comparable for both engines.
Chemoenzymatic synthesis of a novel ligand for rhodium-catalysed asymmetric hydrogenation (1997)

The hydrogenation of alkenes 7a–g using a chiral rhodium catalyst 6 (based on a bicyclo[3.2.0]heptane framework) takes place to give the phenylalanine derivatives 8a–g with remarkably high stereoselectivity (59–92% ee).
Syntheses of (14<i>β</i>,17<i>α</i>)-14-Hydroxy- and (14<i>β</i>,17<i>α</i>)-2,14-Dihydroxyestradiols and Their Activities (1996)

Structure 1 is proposed for the Inagami-Tamura endogenous digitalis-like factor (EDLF), and (14β,17α)-14-hydroxy- and (14β, 17α)-2,14-dihydroxyestradiols (2 and 3) were synthesized as models for studies on 1. The latter compound was remarkably potent in inducing a contractile response in isolated rat aorta and guinea pig left atrium.
Long RNA hairpins that contain inosine are present in <i>Caenorhabditis elegans</i> poly(A) <sup>+</sup> RNA (1999)

Adenosine deaminases that act on RNA (ADARs) are RNA-editing enzymes that convert adenosine to inosine within double-stranded RNA. In the 12 years since the discovery of ADARs only a few natural substrates have been identified. These substrates were found by chance, when genomically encoded adenosines were identified as guanosines in cDNAs. To advance our understanding of the biological roles of ADARs, we developed a method for systematically identifying ADAR substrates. In our first application of the method, we identified five additional substrates in Caenorhabditis elegans. Four of those substrates are mRNAs edited in untranslated regions, and one is a noncoding RNA edited throughout its length. The edited regions are predicted to form long hairpin structures, and one of the RNAs encodes POP-1, a protein involved in cell fate decisions.
Dysbiosis in inflammatory bowel disease: a role for bacteriophages? (2008)

International audience
Education review: Crossing borders--delivering health information management education across state lines. (1996)

Since its inception in 1992, the associate degree program in health information management (HIM) of the University of Alaska Southeast has been distance delivered across the state; it was the first distance degree program to be approved by the university's Board of Regents. In the spring of 1995, the HIM program was selected to be part of a pilot brokering project of the Western Interstate Consortium on Higher Education, in which member institutions would offer programs to or receive programs from other member institutions. The university's HIM program was selected by New Mexico and Wyoming, and classes for two groups of Wyoming students were initiated in the fall of 1995. The article summarizes the results of the project for the HIM program and future plans. It also provides an overview of some of the challenges facing institutions with out-of-state or multistate program delivery.
Pathfinders and trailblazers: a prokaryotic targeting system for transport of folded proteins (2005)

The twin-arginine (Tat) protein translocase is a highly unusual protein transport machine that is dedicated to the movement of folded proteins across the bacterial cytoplasmic membrane. Proteins are targeted to the Tat pathway by means of N-terminal signal peptides harbouring a distinctive twin-arginine motif. In this minireview, we describe our current knowledge of the Tat system, paying particular attention to the function of the TatA protein and to the often overlooked step of signal peptide cleavage.
Cavitation dynamics: II. Free pulsations and models for cavitation bubbles (1975)

A mathematical formalism developed for investigating the dynamics of cavitation bubbles has been used to obtain numerical solutions describing the behavior of bubbles of different initial radii that are damped by heat conduction, viscosity, and compressibility. Calculations have been made to determine two measures of damping, the maximum temperatures, the maximum pressures, and the resonance frequencies of bubbles set into pulsations by a pressure pulse. In general, these quantities are controlled by heat conduction and viscosity at small amplitudes and mainly by compressibility at large amplitudes of motion. One measure of damping—the energy dissipation modulus—has a peak at a well-defined maximum radius. This peak serves to define a transition radius; for pulsations with amplitudes greater than this transition radius, the fraction of available energy dissipated in a cycle decreases and hence very large internal energy densities may occur. A second transition occurs at a radius called the critical radius; for pulsations with amplitudes greater than this critical radius, inertial forces control the collapse of a bubble and very large kinetic energy densities may occur in the liquid at the interface. The transition radius and the critical radius, which are functions of the initial size of a cavity, have been used to define a dynamical threshold for cavitation. In a motion where the maximum radius exceeds this proposed threshold, the characteristic phenomena of cavitation may be expected to appear. The dynamical threshold has in turn been used as the basis for models of cavitation bubbles useful in interpreting such phenomena. Subject Classification: 30.70, 30.60.
A 1.6-nA quiescent current bandgap reference in 130-nm CMOS technology (2015)

This paper presents an ultra-low quiescent current bandgap reference. The BGR is based on a resistor-less topology to reduce area and current consumption. The proposed design was implemented in TSMC 130-nm CMOS technology. It only consumes 1.6 nA from a 1.8-V supply. The BGR provides about 770-mV reference voltage and has power supply rejection ratio (PSRR) of 57 dB at DC. The temperature coefficient (TC) is 5 ppm/°C from -40 to 125 °C. Process variation and mismatches are kept as low as 1.4% per sigma.
Skin-to-skin (kangaroo) holding of the intubated premature infant. (1993)

Skin-to-skin holding has been reported to be a useful technique for helping mothers feel close to their nonintubated infants hospitalized in the NICU. This article describes our experience with skin-to-skin holding of 25 intubated infants in the NICU. We found this technique was safe for the intubated infant and promoted parental attachment, even in parents who were at high risk for attachment impairments. Our experience suggests that skin-to-skin holding with small intubated infants may offer some parents an effective method to overcome some of the barriers to attachment imposed by the infant's hospitalization. In addition, our observations raise several questions regarding parent-infant interaction.
New double wire technique to stent ostial lesions (1997)

We describe a new fast technique to precisely deploy J&J Stents in ostial lesions using two guide wires. The second guide wire is inserted through the proximal stent strut and simultaneously advanced together with the stent on the balloon serving as a position marker that guides stent placement. This technique has been applied in 10 cases with 100% success and with no major complications.
Analogy of Promising Wireless Technologies on Different Frequencies: Bluetooth, WiFi, and WiMAX (2007)

The explosive growth of the Internet over the last decade has led to an increasing demand for high-speed, ubiquitous Internet access. Broadband wireless technologies are increasingly gaining popularity by the successful global deployment of the wireless personal area networks (Bluetooth-IEEE 802.15.1), wireless local area networks (WiFi- IEEE 802.lln), and wireless metropolitan area networks (WiMAX- IEEE 802.16). New ICT and e-Learning strategies and advances in wireless standards and technologies- particularly in the areas of Bluetooth, WiFi (wireless fidelity), WiMAX (worldwide interoperability for microwave access) and mobile computing can help to bridge the digital divide in education and research. Using open broadband Wireless technologies and implementing mobile computing architectures, one can overcome the challenges of ground, infrastructure, and finance to increase access; deploy broadband quickly and cost-effectively to areas currently not served; and extend the benefits of digital revolution to previously unreachable populations. These technologies aim to provide low-cost, high-performance Wireless access to residential and business applications. As technology evolves to address portable and mobile applications, the required features and performance of the system will increase. Evolution toward the phase called "full mobility" provides incremental support for low latency, low packet loss and real-time handoff of subscriber terminals operating at high speeds. This paper presents the analogy of promising wireless technologies on different frequencies: Bluetooth, WiFi, and WiMAX. This paper is organised into four parts: part I describes the functionality and usage of Bluetooth in the wireless personal area networks, part II presents the WiFi- IEEE 802.1 In strategies for users considering higher-bandwidth alternatives to existing wireless personal area networks, part III discusses how the WiMAX is used as a current standard for Wireless data transmission technology, which is optimized to deliver high, bursty data rates to mobile subscribers, and to support real-time multimedia and Voice over IP (VoIP) applications, and part-TV explores how these emerging Wireless technologies differ from one another.
Towards a framework for comparing automatic term recognition methods (2009)

Abstract. Automatic Term Recognition focuses on the extraction of words and multi-word expressions that are significant for a given domain. There is a considerable interest in using ATR for automatic metadata generation, creation of thesauri and terminological glossaries, keyword extraction, ontology building, etc. In this paper, we build upon the work done at the University of Sheffield, where a library with a few algorithms for ATR was recently developed. We enrich this library with new ATR algorithms and tools for evaluation. Our aim is to perform an experimental study comparing the base ATR methods as well as their combinations under various conditions. The results of the study indicate that better precision can be usually reached by combining ATR methods using foreground and ATR methods using background knowledge. The created platform is freely available and prepared for extensions by other researchers. 1 1
Multicolor FISH with improved sensitivity and specificity in the diagnosis of malignant melanoma (2012)

The diagnosis of malignant melanoma remains a challenging aspect in the field of pathology. In the last years, FISH has become an important tool for the diagnosis of melanocytic tumors in addition to conventional microscopy. Benign and malignant melanomas can be discriminated using a four-probe FISH assay targeting 6p25, 6q23, Cep6 and 11q13. Gerami et al. proposed to refine this current probe set with the incorporation of chromosome 8q24 and 9p21 probes into the FISH assay, and hereby increase sensitivity and specificity for distinguishing between benign and malignant melanoma and improve the detection of spitzoid melanomas. In this article, the authors evaluate this newly-defined multicolor FISH probe set for the diagnosis of malignant melanoma. Optimizing diagnostic tests in malignant melanoma are important for current and future management of patients with melanocytic proliferations.
Myocardial beta-adrenergic receptor expression and signal transduction after chronic volume-overload hypertrophy and circulatory congestion. (1992)

Biochemical findings occurred in the absence of myocardial inflammation or fibrosis and without pharmacological interventions, suggesting that circulatory congestion, with attendant elevation in plasma norepinephrine, may be a sufficient stimulus to induce such changes. The data are compatible with a catecholamine-driven beta AR pathway desensitization. Thus, a primary defect in intrinsic contractile function is not a necessary component for abnormalities of the myocardial beta AR-responsive adenylyl cyclase pathway.
<title>Focusing and steering of ultrasonic waves generated by a sixteen-laser source array</title> (1992)

A set of sixteen rectilinear thermoelastic sources, equivalent to a phased array of ultrasonic transducers has been implemented on the surface of an isotropic solid from a multiple beam YAG laser. Introducing a time delay between each laser pulse, the elastic waves were focused in the sample. The ultrasonic beam is detected either by classical piezoelectric transducers or by a compact optical heterodyne probe which is sensitive to the normal displacement of the sample surface. Neglecting heat diffusion in the solid and considering the thermoelastic source as a surface center of expansion, the directivity patterns of laser generated longitudinal acoustic waves have been computed. Experiments performed on duraluminum samples in the thermoelastic regime are presented and compared with this analysis. It is shown that a high focusing and a very good sensitivity for longitudinal waves were achieved with this technique.