gebhart/patrepeval huggingface dataset:
Global Transcriptomic and Proteomic Responses of Dehalococcoides ethenogenes Strain 195 to Fixed Nitrogen Limitation (2011)

Bacteria of the genus Dehalococcoides play an important role in the reductive dechlorination of chlorinated ethenes. A systems-level approach was taken in this study to examine the global transcriptomic and proteomic responses of exponentially growing cells of Dehalococcoides ethenogenes strain 195 to fixed nitrogen limitation (FNL), as dechlorination activity and cell yield both decrease during FNL. As expected, the nitrogen-fixing (nif) genes were differentially upregulated in the transcriptome and proteome of strain 195 during FNL. Aside from the nif operon, a putative methylglyoxal synthase-encoding gene (DET1576), the product of which is predicted to catalyze the formation of the toxic electrophile methylglyoxal and is implicated in the uncoupling of anabolism from catabolism in bacteria, was strongly upregulated in the transcriptome and could potentially play a role in the observed growth inhibition during FNL. Carbon catabolism genes were generally downregulated in response to FNL, and a number of transporters were differentially regulated in response to nitrogen limitation, with some playing apparent roles in nitrogen acquisition, while others were associated with general stress responses. A number of genes related to the functions of nucleotide synthesis, replication, transcription, translation, and posttranslational modifications were also differentially expressed. One gene coding for a putative reductive dehalogenase (DET1545) and a number of genes coding for oxidoreductases, which have implications in energy generation and redox reactions, were also differentially regulated. Interestingly, most of the genes within the multiple integrated elements were not differentially expressed. Overall, this study elucidates the molecular responses of strain 195 to FNL and identifies differentially expressed genes that are potential biomarkers to evaluate environmental cellular nitrogen status.
Acute Occlusion of the Left Circumflex Coronary Artery During Mitral Isthmus Linear Ablation (2005)

Occlusion of LCX During RF Catheter Ablation. We report a case of acute occlusion of the left circumflex coronary artery during catheter ablation in the coronary sinus to complete the linear lesion between the postero-lateral mitral annulus and the left inferior pulmonary vein for the treatment of atrial fibrillation.
Low Exposure X-ray Transmission Measurements for Contrast Media Detection with Filtered X-rays (2003)

A feasibility study of X-ray transmission measurements for contrast media with less exposure using filtered X-rays and their energy information is described. Based on measurements of the energy spectra of La-filtered X-rays, sensitivity to the contrast media and the relative quantity of dose exposure of filtered X-rays as the ratio to white X-rays are shown. The dose exposure for the measurement of iodine contrast media is reduced by more than 50% with a 400/xm thick La filter. By using a filter with atomic number close to that of iodine such as Cs and Ba, a greater reduction in dose exposure with a smaller increase in the current of the X-ray tube is expected.
Metallacycles of the imidoylamidinato compounds HNC(R)NC(R)NH and Group 13 elements. Crystal structure of the complex  [GaMe2{HNC(CF3)NC(CF3 )NH}] (1997)

Reaction of trimethylgallium with trifluoroacetamidine [H 2 NC(CF 3 )NH] resulted in an unusual elimination reaction, and yielded the air-stable volatile metallacycle [GaMe 2 {HNC(CF 3 )NC(CF 3 )NH}] which shows a planar six-membered (GaNCNCN) ring; a related aluminium system [AlMe 2 {HNC(Ph)NC(Ph)NH}] was formed using benzamidine [H 2 NC(Ph)NH].
Study on active steering control of vehicle for safe driving in highway with GPS information (2012)

In recent days, vehicles have become equipped with electric system that assist and help drivers driving safe in highway. Lane Departure Warning and Lane Keeping Assistant System are one of those safe system. Sudden and inattentive lateral motion of vehicle due to drivers' fatigue, illness, inattention, and drowsiness are major causes of accidents in highway. In order to prevent and minimize any possible accidents due to lateral motion of vehicle, active steering control system is designed and simulated in this study. Activation and warning areas are defined for the control system with respect to the location of vehicle and parameters for vehicle dynamics. The current location of vehicle is obtained by Differential Global Positioning System (DGPS) and it can detect DGPS-based lanes then determine whether activates or not.
Integrating Enterprise Communications into Google Wave (2010)

This paper proposes our approach of integrating enterprise telecommunication functions into Google Wave. Our approach can monitor communication events and utilize Google Wave functions to enhance call handling.
The Synthesis and Characterization of Chemically Bonded Silica-Based Zwitterion-Exchangers for HPLC (1986)

The synthesis and characterization of a zwitterionic stationary phase bonded onto microparticulate silica is described. The bonded zwitterionic phase was characterized by elemental analysis, diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), and quantitative analysis of the ligands by high performance liquid chromatography (HPLC) following chemical cleavage from the silica backbone. Chromatographic evaluation of this novel bonded phase indicates that it functions as a weak cation exchanger at pH values above 4.5, an anion exchanger at pH values below 7, and as a zwitterionic phase between these two values. The simultaneous separation of a mixture of cationic, anionic and zwitterionic solutes with this novel bonded phase is shown. Using nucleotides as model compounds, a correlation was developed between maximum solute retention and the pH values corresponding to maximum solute/stationary phase zwitterion overlap. The possibility for a quadrupolar retention mechanism of the bonded zwitterionic phase for zwitterionic solutes is explored.
Asynchronous analogue-to-digital converter for single-electroncircuits (1998)

An analogue-to-digital conversion scheme based on the e-periodic transfer characteristics of an SET inverter is proposed. The authors demonstrate the 4 bit analogue-to-digital converter performance using Monte-Carlo simulation in which an SET inverter implements a binary quantiser and encoder for one significant bit. This scheme can be easily extended to higher order bits.
T Cell Receptor-induced Activation and Apoptosis In Cycling Human T Cells Occur throughout the Cell Cycle (1999)

Previous studies have found conflicting associations between susceptibility to activation-induced cell death and the cell cycle in T cells. However, most of the studies used potentially toxic pharmacological agents for cell cycle synchronization. A panel of human melanoma tumor-reactive T cell lines, a CD8+ HER-2/neu-reactive T cell clone, and the leukemic T cell line Jurkat were separated by centrifugal elutriation. Fractions enriched for the G0-G1, S, and G2-M phases of the cell cycle were assayed for T cell receptor-mediated activation as measured by intracellular Ca(2+) flux, cytolytic recognition of tumor targets, and induction of Fas ligand mRNA. Susceptibility to apoptosis induced by recombinant Fas ligand and activation-induced cell death were also studied. None of the parameters studied was specific to a certain phase of the cell cycle, leading us to conclude that in nontransformed human T cells, both activation and apoptosis through T cell receptor activation can occur in all phases of the cell cycle.
P4‐316: The dual lsd1/maob inhibitor ory2001 prevents the development of the memory deficit in samp8 mice through induction of neuronal plasticity and reduction of neuroinflammation (2015)

ORY2001 is a novel orally bioavailable and brain penetrable inhibitor of Lysine Specific Demethylase 1 (LSD1) and Monoamine oxidaseB (MAOB). MAOB activity is abundant in astrocytes and increases with age and neuroinflammation and degeneration. Modulating MAOB activity, we aim to reduce deleterious MAO activity and GABA production in reactive astrocytes in Alzheimer's disease (AD). LSD1 demethylates H3K4me2/1 and is a transcription modulator. By reducing LSD1 activity, we aim to correct or circumvent transcriptional imbalances that characterize neurodegenerative diseases. Using the NORT test we found ORY2001 completely prevents the development of memory deficit in SAMP8 mice, a model for accelerated aging and AD, at doses between 0.3 and 3 mg/kg administered from 5 months of age. The MAOB inhibitor Rasagiline (3 mg/kg) revealed a trend for improvement which did not reach significance, underscoring the relevance of the LSD1 component in ORY2001. Here we report on our efforts to unravel the mechanism of action underlying ORY2001’s effects on memory. Genomewide expression surveys were performed on mRNA obtained from hippocampal samples from vehicle and ORY2001 treated SAMP8 and of SAMR1 mice. Selected biomarkers were validated by qRTPCR. Microarray analysis on pooled hippocampal samples of female SAMP8 vs SAMR1 samples identified less than 50 genes up or down regulated by > 2 fold (data consistent with Carter et al.). Treatment of SAMP8 mice with ORY2001potently down regulated the expression of genes related to immune reaction and inflammation, including S100A9. Changes in S100A9 expression were validated by Qrtpcr on individual samples and found to be down regulatedin a dose dependent fashion in males and females at 0.96 and 3.2mg/kg (p<0.001). ORY2001also up regulated genes associated with improved cognitive function, neuroplasticity and memory. Down regulation of S100A9 by ORY2001 was particularly interesting since it is emerging as an important contributor to inflammation related neurodegeneration. S100A9 was found to be increased in patients with AD, postoperative cognitive dysfunction and traumatic brain injury; and knockout or knockdown was beneficial to memory in other models of Alzheimer's disease. ORY2001is currently in regulatory toxicology studies and is expected to reach Phase I by the end of 2015.
Betamethasone and the Hormonal Status of the Pregnant Diabetic Woman (1980)

A case is presented illustrating the complicating effects of antepartum steroids on a pregnant diabetic woman. The possible rapid deterioration of the diabetic state and the temporary suppression of estriol production are discussed.
Energy transmission across intact skin for powering artificial internal organs. (1981)

The prototype for a transcutaneous energy transmission system (TETS) meets the engineering goals of high efficiency, limited heating of surrounding tissues due to losses in implanted components, and excellent resistance to misalignment and uncoupling of the coils. Higher efficiencies, reduced thermal generation, and lighter implanted components are the goals of future designs. Improvements will be made based on the findings of a complete in vitro electrical characterization of the present system, varying operating frequency, the number of turns in the 2 coils, and the voltages and currents in the 2 coils. The results of short-term in vivo studies indicate that the temperature rise in tissues surrounding the implanted components is not excessive, that the layer of cutaneous tissue covering the secondary coil is viable and that the thickness of the tissue separating the 2 coils stabilizes after about 2 wks. Definitive statements await the results of in vivo studies lasting longer than 6 mos. Similarly, an evaluation of the effectiveness of butyl as a moisture barrier awaits the results of long-term in vivo, and in vitro immersion test.
Storage Practices of US Gun Owners in 2016 (2018)

Public health campaigns to promote safe gun storage should consider partnering with groups that garner respect among gun owners for their experience with safe use of guns.
Modeling Trust in Online Social Networks to Improve Adolescent Health Behavior (2010)

One of the major public health findings in recent years has been the discovery of the strong impact of an individual's social network on the individual's health as well as habits. A number of studies have shown that physical health factors such as obesity, emotional health factors such as happiness, and habits such as smoking and exercise are significantly impacted by the individual's social network. Based on this, there has been increasing interest in the application of network theory and system dynamics to the study of public health.\n\nAmong a range of public health issues, adolescent health is particularly important for a number of reasons. First, given their developmental stage, adolescents are particularly sensitive to, and impacted by, their social networks. Second, many lifelong health habits or risk behaviors are established during adolescence (e.g. cigarette smoking, alcohol use). Third, adolescents represent the future workforce of the nation, thus their long-term health is critically important for the economy. This makes it especially important to study the impact of social networks on adolescent health.\n\nWhile the invention of the Internet, Web, mobile phones and personal digital assistants have revolutionized many walks of life, the most relevant to our present discussion is the creation of various online social networking sites (e.g. Facebook, MySpace, Twitter). These sites allow new forms of person-to-person interactions, with negligible cost, low latency, and high bandwidth; with the overall effect being one of dramatically increasing the intensity and continuity of communication between people. Many end up spending more attention on online social networks, often at the expense of face-to-face interaction. While this 'attention displacement' from the physical world to the online world potentially raises interesting socio-psychological questions on its own, the fact that the online world is having a significant impact on our lives is unquestioned. Given that usage of online social networking sites is growing at a very rapid rate among adolescents, essentially having become a de facto socialization mechanism in this age group, its impact on adolescent health is expected to be commensurately high, and thus a correspondingly important area of inquiry.\n\nWhile on the one hand the new information and communication technologies have created the tools for new means (and kinds) of socialization, as a complement, the tremendous data collection abilities of these very same technologies provide a perfect opportunity to study these socializations at a granularity which was previously unimaginable. Use of advanced computational methods to analyze detailed behavioral data is bringing about a revolution in the way social science questions can be studied, and has led to the rapid emergence of the discipline of computational social science.\n...<br />[NOTE - Abstract continues in actual report]
Non-specific inhibitors of influenza viruses in normal sera. (1960)

The presence of non-specific inhibitors in immune influenza sera may falsify the antibody pattern as shown by the haemagglutination-inhibition test, and it is consequently often necessary to pre-treat sera in order to inactivate these inhibitors. A number of different methods are in use for this purpose. It was therefore thought useful to compare the efficacy of the various methods with different representative influenza strains and normal sera from eight animal species and acute-phase human sera. Tests were carried out with simple heating at 56 degrees C, the use of receptor-destroying enzyme, the use of potassium periodate, and two methods involving the use of trypsin. No one technique was found to be universally applicable for all types of serum against all strains, and further testing with larger numbers of sera is advocated. It is felt that a combination of potassium periodate and trypsin with a change in concentration and times of action may be found advantageous.
Evaluation of Strength Properties of Sand Modified with Organic Polymers (2018)

Due to weak physical properties of sand, chemical reinforcement methods are widely used to improve sand properties to meet the engineering requirements. However, most of the traditional additives cause environmental problems. Therefore, non-traditional additives such as liquid polymers, enzymes, ions, and lignin derivatives have been studied extensively. In this study, organic polymer is used as a soil stabilizer to reinforce the sand. To evaluate the effectiveness of the organic polymer as soil stabilizer, a series of unconfined compression strength (UCS) tests, direct shear tests, and tensile tests were carried out on reinforced sand with different polymer concentrations and dry densities of sand. The reinforcement mechanism was analysed with scanning electron microscopy (SEM) images. The results indicated that the polymer concentration and dry density of sand had significant effects on the strength characteristics of reinforced sand specimens. The unconfined compressive strength, cohesion, and tensile strength of specimens with the same dry density increased with the increasing polymer concentration. The polymer membranes-formed by the mixture of polymer and water-enwrap the sand particles and interlink them to form a stable structure. The efficiency of this stabilization changed with dry sand density.
Design, Synthesis, and Preliminary Pharmacological Evaluation of <i>N</i>-Acyl-3-aminoglutarimides as Broad-Spectrum Chemokine Inhibitors in Vitro and Anti-inflammatory Agents in Vivo (2001)

A series of N-substituted 3-aminoglutarimides have been synthesized and tested for inhibitory activity against a range of chemokines in vitro and for suppression of lipopolysaccharide-induced inflammation in vivo. The results show that they represent the first class of small molecules with broad-spectrum chemokine inhibitory effects. Among the compounds studied, 10 (NR58,4) was the most potent, being active at doses between 5 and 15 nM in vitro and at 0.3 mg kg(-1) in vivo.
Methyl Bromide Emissions from Agricultural Fields:  Bare-Soil, Deep Injection (1997)

The environmental fate and transport of methyl bromide (MeBr) in an agricultural field after deep injection (68 cm) is described and compared to a recent experiment where MeBr was injected at a shallow (25 cm) depth, and the surface was covered with high-density polyethylene plastic. Three independent methods were used to estimate the total MeBr lost after application, i.e., the appearance of soil Br-, the flux chamber, and micrometeorological methods. Peak MeBr volatilization rates occurred during the first 24 h, but relatively high rates continued for more than 7 days after application. Diurnally, the largest volatilization rates oc curred from midnight to early morning during periods of decreasing barometric pressure, and the volatilization rate decreased when the barometric pressure was increasing. Due to deep injection, cooler temperatures, and smaller thermal gradients, the total MeBr mass emitted from the field was significantly less than a previous experiment. The total emissions estimate obtained from the Br- data was 239 kg or 21%. The estimates obtained from the direct flux measurements were found to range from 1.9% to 4.9%. The percent mass recovery ranged from 81% to 84% of the applied mass, with an average value of 82%. The discrepancy between Br- and direct flux measurements was attributed to losses from the shank fracture during or immediately after injection. It is important to understand how deep injection affects MeBr emissions so that the total fumigant loss from agricultural fields can be minimized.
The human T-cell leukemia-lymphoma virus in the southeastern United States (1983)

The human T-cell leukemia-lymphoma virus (HTLV) is a recently described RNA tumor virus associated with human T-cell malignant neoplasms. In two geographic areas, Japan and the Caribbean basin, clusters of adult T-cell leukemia-lymphoma are "sentinel diseases" and have suggested an underlying prevalence of HTLV infection in both family members of the index cases and in the population. Four cases of lymphoma from the United States are described as illustrative of the sentinel disease. Serological studies of families and of a small population sample suggest that HTLV infection is endemic in certain parts of the southeastern United States at rates similar to those seen in Caribbean blacks but at a lower rate than that observed in southwestern Japan. (<i>JAMA</i>1983;250:1048-1052)
What Lies Beneath: The Linguistic Traces of Deception in Online Dating Profiles (2012)

This article investigates whether deceptions in online dating profiles correlate with changes in the way daters write about themselves in the free-text portion of the profile, and whether these changes are detectable by both computerized linguistic analyses and human judges. Computerized analyses (Study 1) found that deceptions manifested themselves through linguistic cues pertaining to (a) liars' emotions and cognitions and (b) liars' strategic efforts to manage their self-presentations. Technological affordances (i.e., asynchronicity and editability) affected the production of cognitive cues more than that of emotional cues. Human judges (Study 2) relied on different and nonpredictive linguistic cues to assess daters' trustworthiness. The findings inform theories concerned with deception, media, and self-presentation, and also expound on how writing style influences perceived trustworthiness.
Probabilistic programming in Python using PyMC3 (2016)

Probabilistic programming allows for automatic Bayesian inference on user-defined probabilistic models. Recent advances in Markov chain Monte Carlo (MCMC) sampling allow inference on increasingly complex models. This class of MCMC, known as Hamiltonian Monte Carlo, requires gradient information which is often not readily available. PyMC3 is a new open source probabilistic programming framework written in Python that uses Theano to compute gradients via automatic differentiation as well as compile probabilistic programs on-the-fly to C for increased speed. Contrary to other probabilistic programming languages, PyMC3 allows model specification directly in Python code. The lack of a domain specific language allows for great flexibility and direct interaction with the model. This paper is a tutorial-style introduction to this software package.
MEMS microswitch arrays for reconfigurable distributed microwave components (2002)

A novel MEMS switch design for use in microwave circuits is presented. The microswitch is capable of being configured in a multi-element X-Y array for use in tunable distributed circuits. Circuit design concepts using microswitch arrays and measurements of single microswitch performance are given.
Board Recommendation in Pinterest. (2013)

Abstract. In this paper we describe preliminary approaches for contentbased recommendation of Pinterest boards to users. We describe our representation and features for Pinterest boards and users, together with a supervised recommendation model. We observe that features based on latent topics lead to better performance than features based on userassigned Pinterest categories. We also find that using social signals (repins, likes, etc.) can improve recommendation quality.