gebhart/patrepeval huggingface dataset:
TL1A Induces TCR Independent IL-6 and TNF-α Production and Growth of PLZF+ Leukocytes (2014)

An elevated level of the cytokine TL1A is known to be associated with several autoimmune diseases, e.g. rheumatoid arthritis and inflammatory bowel disease. However, the mode of action of TL1A remains elusive. In this study, we investigated the role of TL1A in a pro-inflammatory setting, using human leukocytes purified from healthy donors. We show that TL1A, together with IL-12, IL-15 and IL-18, directly induces the production of IL-6 and TNF-α from leukocytes. Interestingly, TL1A-induced IL-6 was not produced by CD14⁺ monocytes. We further show that the produced IL-6 is fully functional, as measured by its ability to signal through the IL-6 receptor, and that the induction of IL-6 is independent of TCR stimulation. Furthermore, the transcription factor PLZF was induced in stimulated cells. These results offer a substantial explanation for the role of TL1A, since TNF-α and IL-6 are directly responsible for much of the inflammatory state in many autoimmune diseases. Our study suggests that TL1A is a possible target for the treatment of autoimmune diseases.
Neutron Powder Diffraction Study of Molybdenum and Tungsten Dioxides (1995)

Neutron powder diffraction data for MoO2 [P21/c, a 5.6102(3), b 4.8573(2), c 5.6265(3) ?, ß 120.915(2)°] and WO2 [P21/c, a 5.5769(2), b 4.8986(1), c 5.6644(2) ?, ß 120.678(1)] have been employed to refine structural parameters by the Rietveld method. The results confirm previous studies but have considerably greater precision.
Adaptive IIR filtering (1989)

An overview is presented of several methods, filter structures, and recursive algorithms used in adaptive infinite-impulse response (IIR) filtering. Both the equation-error and output-error formulations are described, although the focus is on the adaptive algorithms and properties of the output-error configuration. These parameter-update algorithms have the same generic form, and they are based on a prediction-error performance criterion. A direct-form implementation of the adaptive filters is emphasized, but alternative realizations such as the parallel and lattice forms are briefly discussed. Several important issues associated with adaptive IIR filtering, including stability monitoring, the SPR condition, and convergence, are addressed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Unsaturated Synthetic Glycerides. II. Unsymmetrical Dioleo-monosaturated Triglycerides<sup>1</sup> (1943)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnsaturated Synthetic Glycerides. II. Unsymmetrical Dioleo-monosaturated Triglycerides1B. F. Daubert, C. J. Spiegl, and H. E. LongeneckerCite this: J. Am. Chem. Soc. 1943, 65, 11, 2144–2145Publication Date (Print):November 1, 1943Publication History Published online1 May 2002Published inissue 1 November 1943https://pubs.acs.org/doi/10.1021/ja01251a036https://doi.org/10.1021/ja01251a036research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Validation of hand and foot anatomical feature measurements from smartphone images (2018)

A smartphone mobile medical application, previously presented as a tool for individuals with hand arthritis to assess and monitor the progress of their disease, has been modified and expanded to include extraction of anatomical features from the hand (joint/finger width, and angulation) and foot (length, width, big toe angle, and arch height index) from smartphone camera images. Image processing algorithms and automated measurements were validated by performing tests on digital hand models, rigid plastic hand models, and real human hands and feet to determine accuracy and reproducibility compared to conventional measurement tools such as calipers, rulers, and goniometers. The mobile application was able to provide finger joint width measurements with accuracy better than 0.34 (±0.25) millimeters. Joint angulation measurement accuracy was better than 0.50 (±0.45) degrees. The automatically calculated foot length accuracy was 1.20 (±1.27) millimeters and the foot width accuracy was 1.93 (±1.92) millimeters. Hallux valgus angle (used in assessing bunions) accuracy was 1.30 (±1.29) degrees. Arch height index (AHI) measurements had an accuracy of 0.02 (±0.01). Combined with in-app documentation of symptoms, treatment, and lifestyle factors, the anatomical feature measurements can be used by both healthcare professionals and manufacturers. Applications include: diagnosing hand osteoarthritis; providing custom finger splint measurements; providing compression glove measurements for burn and lymphedema patients; determining foot dimensions for custom shoe sizing, insoles, orthotics, or foot splints; and assessing arch height index and bunion treatment effectiveness.
Content-addressability and learning in neural networks (1988)

The content-addressability of patterns stored in Ising-spin neural network models with symmetric interactions is studied. Numerical results from simulations on the ICL distributed array processor (DAP) involving systems with up to 2048 neurons are presented. Behaviour consistent with finite-size scaling, characteristic of a first-order phase transition, is shown to be exhibited by the basins of attraction of the stored patterns both in the case of the Hopfield model and for systems using a local iterative learning algorithm designed to optimise the basins of attraction. Estimates are obtained for the critical minimum overlaps which an input pattern must have with a stored pattern in order to successfully retrieve it.
Library Services to the Visually Handicapped in Korea : Changes in the Information Environment and Role of Braille Library(Lifelong and Continuing Education in Libraries) (2005)

Information (retrieval) environment for the blind has been extended from Braille library to web pages for the blind.And Braille libraries have also responded to the change.First, the main role of Braille libraries is to process printed materials into accessible units, and make them available to the blind.In addition, Braille libraries provide new types of services through the internet.Braille libraries now produce information specific to the blind and assist them in navigating the internet to retrieve precisely the desired information out of the mass of general information.Thus they remain important even while changing the form of their services in response to the new information environment.
Dopamine-induced dissociation between renal metabolic rate and sodium reabsorption (1976)

The stimulatory effect of dopamine on renal energy metabolism and its relationship to changes in tubular sodium reabsorption and plasma concentration of free fatty acids (FFA) were examined in anesthetized dogs. Dopamine infused intravenously at 25 mug/kg body wt-min for 30-60 min increased renal oxygen consumption (Rvo2) by 28 +/- 3%; glomerular filtration rate rose from 37 +/- 3 to 40 +/- 2 ml/min without significant changes in sodium excretion. Plasma FFA increased about 6 times. Total-body metabolic rate increased to 152 +/- 7% and fell to 119 +/- 5% of control after normalizing plasma FFA by beta-pyridylcarbinol; Rvo2 remained unchanged. Cortical and outer medullary heat accumulation rated increased to 137 +/- 6 and 133 +/- 10% after 1 h and to 163 +/- 18 and 179 +/- 26% of control after 2 h of dopamine infusion without further changes in sodium reabsorption. Furosemide reduced cortical and outer medullary metabolic rates as much as in control experiments (14 +/- 8 and 69 +/- 7%, respectively). Hence, dopamine exerts a renal calorigenic effect which cannot be accounted for by increased sodium reabsorption or attributed to increased supply of FFA.
[Purification and some characteristics of germins G and psiG from wheat]. (2004)

By affinity chromatography, germins G and psiG were purified from roots of wheat seedling and wheat embryos imbibition for 4 h. Characterization of the germins G and psiG were studied. The results showed that G and psiG were stable at temperatures lower than 60 degrees C, and had an optimum pH at 3.5. The Km value of G for oxalate was 0.084 mmol/L, while that of psiG was 0.053 mmol/L. Oxalate showed substrate inhibition effect above 0.2 mmol/L on G and psiG. EDTA, NH(+)(4), Mn(2+), Mg(2+), Na(+) and K(+) at a concentration of 0.1 mmol/L had no effect on OxO activity. CO(2-)(3), NO(-)(3) and SO(2-)(4) at a concentration of 0.1 mmol/L inhibited partially the activities of G and psiG, 0.1 mmol/L Cu(2+), Fe(2+), Al(3+) completely inhibited the activities of G and psiG, but addition of 0.1 mmol/L EDTA partially relieved the inhibition, which indicated that metal cations may make the oxalate unavailable by chelating it. H(2)PO(-)(4) and HPO(2-)(4) inhibited the activity of G, but had no effect on psiG. Riboflavin, FMN and FAD inhibited psiG, but FMN and FAD had no effect on G.
Continuous activation of Li2MnO3 component upon cycling in Li1.167Ni0.233Co0.100Mn0.467Mo0.033O2 cathode material for lithium ion batteries (2012)

Li-rich layered cathode materials are very promising candidates for next generation high energy lithium ion batteries. One of the Li-rich layered cathode materials, Li1.167Ni0.233Co0.100Mn0.467Mo0.033O2 is prepared by a co-precipitation method. In this report, we focus on anomalous changes upon cycling in Li1.167Ni0.233Co0.100Mn0.467Mo0.033O2 cathode material in a voltage range of 2.0–4.55 V at room temperature. The structural transitions upon cycling are analyzed by ex situ X-ray diffraction. In addition, the changes in local structure during cycling are studied by X-ray absorption near edge structure. With differential capacity plots by controlling the cut-off voltage, the voltage decay during cycling is intensively studied. The continuous activation process of the residual Li2MnO3 component during cycling is correlated with voltage decay during cycling, and increasing capacity during the initial several cycles. Also, the electrochemical performance in Li1.167Ni0.233Co0.100Mn0.467Mo0.033O2 cathode material below 4.4 V is discussed. Furthermore, cycle performance is improved by reassembling Li1.167Ni0.233Co0.100Mn0.467Mo0.033O2 into another cell after washing.
An internet based RFID library management system (2013)

Radio Frequency IDentification (RFID) is the wireless non-contact system that uses radio-frequency waves to transfer data from a tag attached to an object, for the automatic identification and tracking. An internet based concept is incorporated with RFID technology to form an internet based application for the library management. The RFID reader Motorola MC9090 is used for the entire process which is carried inside the library. This reader is a compatible reader that can read any kind of tag of frequencies like Low, High & Ultra High. Every user and every book is provided with a RFID Tag which has a dedicated, unique EPC (Electronic Product Code) which is made in relation to the database for the further details. Internet concepts are put forward with the help of Internet of Things architectural layer. The idea of monitoring and sensing the library environment from a location and to identify the materials, books, CD's, etc present inside the library for easy access of the library which was observed to be the most common issue. In this paper the problems & issues faced in the library environment like locating the mis-placed or mis-shelved book or materials, reducing the manual work & ease access of the books are done and a solution is developed that could overcome these problems with the better enhanced work.
A comparative analysis of machine learning methods for classification type decision problems in healthcare (2014)

Abstract Advanced analytical techniques are gaining popularity in addressing complex classification type decision problems in many fields including healthcare and medicine. In this exemplary study, using digitized signal data, we developed predictive models employing three machine learning methods to diagnose an asthma patient based solely on the sounds acquired from the chest of the patient in a clinical laboratory. Although, the performances varied slightly, ensemble models (i.e., Random Forest and AdaBoost combined with Random Forest) achieved about 90% accuracy on predicting asthma patients, compared to artificial neural networks models that achieved about 80% predictive accuracy. Our results show that non-invasive, computerized lung sound analysis that rely on low-cost microphones and an embedded real-time microprocessor system would help physicians to make faster and better diagnostic decisions, especially in situations where x-ray and CT-scans are not reachable or not available. This study is a testament to the improving capabilities of analytic techniques in support of better decision making, especially in situations constraint by limited resources.
Multiresponsive Square Hybrid Nanosheets of POSS-Ended Hyperbranched Poly(ether amine) (hPEA) (2012)

We demonstrated a novel square hybrid nanosheet with a ultrathin thickness for the first time, which was fabricated by self-assembly of hyperbranched poly(ether amine) (hPEA526) containing anthracene (AN) moieties and heptaisobutyl polyhedral oligomeric silsesquioxane (POSS). TEM and AFM images reveal that the average edge length and thickness of the hybrid nanosheets formed by HP1 is 1.2 ± 0.2 μm and 4.5 ± 0.5 nm, respectively. POSS prefers the ordered crystallized aggregation in the formation of the regular square nanosheets, which is confirmed by WAXD and DSC studies. Moreover, these nanosheets are cross-linked through dimerization of anthracene moieties which makes the nanosheets more stable. The other functional moieties such as naphthalene, pyrene, and dodecane can also be easily introduced into the hybrid nanosheets through the same way. The obtained hybrid nanosheets exhibit the multiresponses to temperature and pH, and their dispersion in water can be controlled by temperature. The fluorescence of the hybrid nanosheets decreases with the increasing temperature and pH. The discovery of the hybrid nanosheets is believed to provide a potential guiding significance on the preparation of the functional nanosheets by self-assembly of polymers.
Formation of a Guanidinate-Supported Titanium Imido Complex:  A Catalyst for Alkyne Hydroamination (2002)

The reaction of [{(Me2N)C(NiPr)2}2TiMe2] with 1 equiv of 2,6-dimethylphenyl isocyanide yields the terminal Ti imido complex [{(Me2N)C(NiPr)2}2TiNAr‘] (Ar‘ = 2,6-Me2C6H3) (4). Complex 4 is an effective catalyst for the hydroamination of alkynes and reacts with H2NAr‘ to yield a complex with a transformed guanidinate ligand, [{(iPr(H)N)C(NiPr)(NAr‘)}2TiNAr‘] (5).
Antiulcer activity of dehydroabietic acid derivatives. (1985)

Derivatives of dehydroabietic acid (1) having a hydrophilic moiety (such as amino, carbamoyl, carbamoyloxy, ureido, sulfamoyl, or sulfo) at positions 12 and/or 18 of the dehydroabietane nucleus were prepared and tested for antiulcer activity by means of antisecretory and antipepsin assays in rats. Among these compounds, the salts of 12-sulfodehydroabietic acid (62, 63, and 64) were found to exhibit remarkably high antipepsin activity without aldosterone-like activity.
Cecilia Payne-Gaposchkin: An Autobiography and Other Recollections (1984)

Katherine Haramundanis (ed) 1984 Cambridge: Cambridge University Press vi + 269 pp price £19.50 ISBN 0 521 25752 2
Peptide and carbohydrate vaccines in relapsed prostate cancer: immunogenicity of synthetic vaccines in man--clinical trials at Memorial Sloan-Kettering Cancer Center. (1999)

Men with rising prostate-specific antigen (PSA) levels after primary therapies such as prostatectomy or radiotherapy represent a unique group for whom no standard treatment option exists. A variety of approaches including expectant monitoring, dietary modification, hormonal therapy, and alternative medicines have shown an impact on the rate of increase in PSA, but the overall effect on survival remains controversial. At Memorial Sloan-Kettering Cancer Center, we have focused our treatment approach on this cohort of patients in a series of phase I monovalent carbohydrate and glycoprotein-conjugate vaccine trials using the patients' immune system to generate an antitumor response. These synthetic vaccines are conjugated to keyhole limpet hemocyanin (KLH) and given with the immunologic adjuvant QS21 as five subcutaneous vaccines over 26 weeks. All patients generated specific high-titer immunoglobulin M (IgM) and/or IgG antibodies, some of which were able to mediate complement lysis. Preliminary data suggest that these vaccines may impact on the rate of increase in posttreatment PSA slopes compared with pre-PSA values. The impact of vaccine therapy on the PSA slope and its effect on the time to radiographic progression are the current focus of a forthcoming phase II trial. Vaccines may offer an alternative treatment option for the patient who has relapsed early following primary therapies.
Artifacts in spine magnetic resonance imaging due to different intervertebral test spacers: an in vitro evaluation of magnesium versus titanium and carbon-fiber-reinforced polymers as biomaterials (2009)

Our results suggest that spinal implants made with magnesium alloys will behave more like CFRP devices in MRI scans. Given its osseoconductive potential as a metal, implant alloys made with magnesium would combine the advantages to the two principal spacer materials currently used but without their limitations, at least in terms of MRI artifacting.
Synthesis of amphiphilic block–graft copolymers [poly(styrene‐<i>b</i>‐ethylene‐<i>co</i>‐butylene‐<i>b</i>‐styrene)‐<i>g</i>‐poly(acrylic acid)] and their aggregation in water (2002)

Abstract Novel block–graft copolymers [poly(styrene‐ b ‐ethylene‐ co ‐butylene‐ b ‐styrene)‐ g ‐poly( tert ‐butyl acrylate)] were synthesized by the atom transfer radical polymerization (ATRP) of tert ‐butyl acrylate (tBA) with chloromethylated poly(styrene‐ b ‐ethylene‐ co ‐butylene‐ b ‐styrene) (SEBS) as a macromolecular initiator. The copolymers were composed of triblock SEBS as the backbone and tBA as grafts attached to the polystyrene end blocks. The macromolecular initiator (chloromethylated SEBS) was prepared by successive hydrogenation and chloromethylation of SEBS. The degree of chloromethylation, ranging from 1.6 to 36.5 mol % according to the styrene units in SEBS, was attained with adjustments in the amount of SnCl 4 and the reaction time with a slight effect on the monodispersity of the starting material (SEBS). The ATRP mechanism of the copolymerization was supported by the kinetic data and the linear increase in the molecular weights of the products with conversion. The graft density was controlled with changes in the functionality of the chloromethylated SEBS. The average length of the graft chain, ranging from a few repeat units to about two hundred, was adjusted with changes in the reaction time and alterations in the initiator/catalyst/ligand molar ratio. Incomplete initiation was detected at a low conversion; moreover, for initiators with low functionality, sluggish initiation was overcome with suitable reaction conditions. The block–graft copolymers were hydrolyzed into amphiphilic ones containing poly(acrylic acid) grafts. The aggregation behavior of the amphiphilic copolymers was studied with dynamic light scattering and transmission electron microscopy, and the aggregates showed a variety of morphologies. © 2002 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 40: 1253–1266, 2002
Speech/gesture interface to a visual computing environment for molecular biologists (1996)

Recent progress in 3-D, immersive display and virtual reality (VR) technologies has made possible many exciting applications, for example interactive visualization of complex scientific data. To fully exploit this potential there is a need for "natural" interfaces that allow the manipulation of such displays without cumbersome attachments. In this paper we describe the use of visual hand gesture analysis and speech recognition for developing a speech/gesture interface for controlling a 3-D display. The interface enhances an existing application, VMD, which is a VR visual computing environment far molecular biologists. The free hand gestures are used for manipulating the 3-D graphical display together with a set of speech commands. We describe the visual gesture analysis and the speech analysis techniques used in developing this interface. The dual modality of speech/gesture is found to greatly aid the interaction capability.
Antimicrobial Activity of Novel Furanonaphthoquinone Analogs (1998)

Analogs of furanonaphthoquinone (FNQ) from Tecoma ipe Mart had MICs ranging from 1.56 to 25 microg/ml against gram-positive bacteria. FNQ showed significantly lower MICs against methicillin-resistant Staphylococcus aureus than against methicillin-sensitive S. aureus. FNQ inhibited Helicobacter pylori with an MIC of 0.1 microg/ml. Fungi, including pathogenic species, were sensitive to FNQ with MICs similar to those of amphotericin B.
Study on synthesis of n-butyl acetate using inorganic salt as catalyst (2002)

The catalytic behaviors of FeCl 3·6H 2O, CuCl 2·2H 2O, CuSO 4·5H 2O, CuSO 4, FeSO 4·7H 2O, ZnSO 4·7H 2O in esterification of n butyl alcohol with acetic acid are studied. It is shown that FeCl 3 CuCl 2 has better catalytic properties; in a continuous esterifying-distillating system the catalyst has good stability and activity after 150 hours reacted.
The RISC II micro-architecture (1984)

Le projet RISC etudie les implications des simplifications d'un ensemble d'instructions d'un ordinateur de propos general. Presentation de la microarchitecture d'une seconde implementation NMOS, RISC II. Presentation de l'organisation de la section de controle. On donne les metriques de conception de RISC II
Nonlamellar Liquid Crystalline Phases and Their Particle Formation in the Egg Yolk Phosphatidylcholine/Diolein System (2003)

The phase behavior of fully hydrated egg yolk phosphatidylcholine (EPC)/diolein (DO) mixtures was investigated by small-angle X-ray scattering and 31P NMR. EPC formed a lamellar phase, whereas DO gave a negative curvature to the lipid membranes, leading to nonlamellar phase formation. At an EPC/DO molar ratio of 8:2, the mixture formed a bicontinuous cubic phase of primitive type. A bicontinuous cubic phase of diamond type was also observed at the ratio of 7:3, but it coexisted with an inverted hexagonal (HII) phase. The mixture with higher DO fractions formed the HII phase. We further investigated if these nonlamellar phases could be dispersed by high-pressure emulsification with Pluronic F127, to form cubosomes or hexosomes, as have been obtained in monoolein-based cubic and HII phases (Langmuir 2001, 17, 3917−3922; Langmuir 2002, 18, 9283−9288). As a result, cubosomes could not be obtained and vesicles were formed instead, presumably due to the existence of F127, which gave a positive curvature to the negatively curved membranes. However, the HII phase, which was less compatible with F127, could be dispersed to form hexosomes.