gebhart/patrepeval huggingface dataset:
Research and Application of Warehouse Receipt Transaction Based on Smart Contract on the Blockchain (2018)

To solve the credibility and supervision lacking problem in the OTC warehouse receipt trading system, a scheme of using smart contract on the blockchain to implement the OTC warehouse receipt trading system is presented. As a distributed ledger, blockchain has the advantages of decentralization, irreversibility and trustworthiness. The warehouse receipt transaction data is recorded on the blockchain, ensuring its safety and credibility. Smart contract is automatically executed code stored on the blockchain, it can directly control the transaction of digital assets. No participant can control and tamper it before the contract is lapsed. In the process of using the Ethereum smart contract to realize warehouse receipt transactions, consensus is reached by the PBFT consensus algorithm, Since the trusted third-party is not needed, the lack of supervision problem is solved. This paper introduces the application of blockchain and smart contract to the OTC warehouse receipt trading system. It includes the design of smart contracts, the verification of smart contracts security. This paper also verifies the feasibility of designing smart contracts by using the instance of listed transactions.
Synthetic studies on nucleoside antibiotics. 13. Inhibitors of protein synthesis. 4. Structure-activity relation of gougerotin and some of its analogs (1975)

Seventeen structural analogs of gougerotin have been compared with the parent compound as inhibitors of the growh of E. coli B and as inhibitors of N-acetylphenylalanylpuromycin formation. The analogs comprise compounds with (1) an intact sarcosyl-D-seryl moiety and modifications at various positions of the carbohydrate moiety, (2) compounds which lack the peptidyl residue, and (3) compounds in which the sarcosyl-D-seryl moiety has been replaced by other aminoacyl or peptidyl moieties and in which various sites in the carbohydrate moiety have been modified in addition. These comparisons revealed that (1) the 3'-hydroxyl group makes a strong contribution to inhibitory activity, (2) the introduction of a double bond between the 2' and 3' positions of the carbohydrate moiety causes a marked decrease in activity; however, if in addition the sarcosyl-D-seryl moiety is replaced by the epsilon-N-methyl-beta-L-arginyl side chain, full activity is restored, (3) there is a marked degree of stereospecificity around the alpha carbon of the seryl moiety (replacement of the sarcosyl-D-seryl residue with the sarcosyl-L-seryl residue results in greatly reduced activity), and (4) replacement of the carboxamide group at position 5' with a hydroxymethyl function resulsts in reduced activity which is further decreased by alterations in the sarcosyl-D-seryl moiety. These alterations include (a) replacement of the D-seryl residue of the sarcosyl-D-seryl moiety by the D-alanyl or the D-phenylalanyl residues and (b) replacement of the whole sarcosyl-D-seryl side chain by the D-seryl, D-alanyl, D-phenylalanyl, p-methoxy-D-phenylalanyl, or p-methoxy-L-phenylalanyl moieties; the replacement of the sarcosyl-D-seryl side chain with the various aminoacyl residues did not lead to acceptor (puromycin-like) activity with N-Ac-Phe-tRNA as the donor.
Rapid, Facile Microwave-Solvothermal Synthesis of Graphene Nanosheets and Their Polyaniline Nanocomposites for Energy Strorage (2009)

We report here a rapid, microwave-solvothermal synthesis of graphene nanosheets within few minutes at <300 °C without requiring highly toxic chemicals with strong reducing properties or reducing gas atmospheres at elevated temperatures. The graphene nanosheets produced are decorated with polyaniline nanocomposites and exhibit high charge storage capacity in lithium ion batteries and electrochemical capacitors.
Homogeneous Acetylation of Cellulose in a New Ionic Liquid (2004)

Acetylation of cellulose has been accomplished in a new room-temperature ionic liquid, 1-allyl-3-methylimidazolium chloride, in the absence of any catalysts, and cellulose acetates with a wide range of degree of substitution have been obtained directly under homogeneous reaction conditions.
Phosphorylation of glycerol and dihydroxyacetone in Acetobacter xylinum and its possible regulatory role (1976)

Extracts of Acetobacter xylinum catalyze the phosphorylation of glycerol and dihydroxyacetone (DHA) by adenosine 5'-triphosphate (ATP) to form, respectively, L-alpha-glycerophosphate and DHA phosphate. The ability to promote phosphorylation of glycerol and DHA was higher in glycerol-grown cells than in glucose- or succinate-grown cells. The activity of glycerol kinase in extracts is compatible with the overall rate of glycerol oxidation in vivo. The glycerol-DHA kinase has been purified 210-fold from extracts, and its molecular weight was determined to be 50,000 by gel filtration. The glycerol kinase to DHA kinase activity ratio remained essentially constant at 1.6 at all stages of purification. The optimal pH for both reactions was 8.4 to 9.2. Reaction rates with the purified enzyme were hyperbolic functions of glycerol, DHA, and ATP. The Km for glycerol is 0.5 mM and that for DHA is 5 mM; both are independent of the ATP concentration. The Km for ATP in both kinase reactions is 0.5 mM and is independent of glycerol and DHA concentrations. Glycerol and DHA are competitive substrates with Ki values equal to their respective Km values as substrates. D-Glyceraldehyde and l-Glyceraldehyde were not phosphorylated and did not inhibit the enzyme. Among the nucleotide triphosphates tested, only ATP was active as the phosphoryl group donor. Fructose diphosphate (FDP) inhibited both kinase activities competitively with respect to ATP (Ki= 0.02 mM) and noncompetitively with respect to glycerol and DHA. Adenosine 5'-diphosphate (ADP) and adenosine 5'-monophosphate (AMP) inhibited both enzymic activities competitively with respect to ATP (Ki (ADP) = 0.4 mM; Ki (AMP) =0.25 mM). A. xylinum cells with a high FDP content did not grow on glycerol. Depletion of cellular FDP by starvation enabled rapid growth on glycerol. It is concluded that a single enzyme from A. xylinum is responsible for the phosphorylation of both glycerol and DHA. This as well as the sensitivity of the enzyme to inhibition by FDP and AMP suggest that it has a regulatory role in glycerol metabolism.
Recursive Star-Tree Parallel Data Structure (1993)

This paper introduces a novel parallel data structure called the recursive star-tree (denoted “${}^ * $-tree”). For its definition a generalization of the $ * $ functional is used (where for a function $f * f(n) = \min \{ {i|f^{(i)} (n) \leqslant 1} \}$ and $f^{(i)} $ is the ith iterate of f). Recursive ${}^ * $-trees are derived by using recursion in the spirit of the inverse Ackermann function. The recursive ${}^ * $-tree data structure leads to a new design paradigm for parallel algorithms. This paradigm allows for extremely fast parallel computations, specifically, $O(\alpha (n))$ time (where $\alpha (n)$ is the inverse of the Ackermann function), using an optimal number of processors on the (weakest) concurrent-read, concurrent-write parallel random-access machine (CRCW PRAM). These computations need only constant time, and use an optimal number of processors if the following nonstandard assumption about the model of parallel computation is added to the CRCW PRAM: an extremely small number of processors each can write simultaneously into different bits of the same word. Applications include finding lowest common ancestors in trees by a new algorithm that is considerably simpler than the known algorithms for the problem, restricted domain merging, parentheses matching, and a new parallel reducibility.
A Four-Layers Hierarchical Clustering Topology Architecture with Sleep Mode in a Wireless Sensor Network (2013)

In this paper, our proposed architecture involve new four-layer clustering topology architecture based on LEACH architecture. We propose four-layer clustering topology architecture: the Random Cluster Head and Maximum Energy Sub-cluster Head with Relay node and Sleep mode (RCHMESHR-S) architecture, the aim is to improve energy efficiency and extend the lifetime of wireless sensor networks. The RCHMESHR-S architecture considers the residual energy of wireless sensor nodes when selecting the sub-cluster head and relay node, in order to increase the energy efficiency of a wireless sensor network. Furthermore, the RCHMESHR-S architecture uses correlations among sensor data within wireless sensor nodes to develop a sleep mode that can effectively reduce energy consumption. Simulation results show that the performances of our proposed RCHMESHR-S architecture is better than that of the LEACH architecture in terms of initial node death and the number of nodes alive.
Activated Epidermal Growth Factor Receptor–Stat-3 Signaling Promotes Tumor Survival<i>In vivo</i>in Non–Small Cell Lung Cancer (2005)

Early-stage NSCLC tumors have activated EGFR-Stat3 signaling with low apoptosis. Our findings suggest that pStat3 expression may be helpful in identifying patients appropriate for treatment with EGFR tyrosine kinase inhibitors.
X-ray Photoelectron Spectroscopy Analysis of Solid-Phase Reactions Using 3-Brominated Wang Resin (1999)

ADVERTISEMENT RETURN TO ISSUEReportNEXTX-ray Photoelectron Spectroscopy Analysis of Solid-Phase Reactions Using 3-Brominated Wang ResinSung-eun Yoo, Young-Dae Gong, Jin-soo Seo, Myung M. Sung, Sun Sook Lee, and Yunsoo KimView Author Information The Bio-Organic Division and the Advanced Materials Division, Korea Research Institute of Chemical Technology, Yusong, P.O. Box 107, Taejon 305-600, Korea Cite this: J. Comb. Chem. 1999, 1, 3, 177–180Publication Date (Web):March 13, 1999Publication History Received27 October 1998Published online13 March 1999Published inissue 1 May 1999https://pubs.acs.org/doi/10.1021/cc980029nhttps://doi.org/10.1021/cc980029nbrief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views289Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Elements,Organic polymers,Polymers,X-ray photoelectron spectroscopy,X-rays Get e-Alerts
Range Resampling in the Polar Format Algorithm for Spotlight SAR Image Formation Using the Chirp $z$-Transform (2007)

Besides an inverse two-dimensional (2-D) Fourier transform, the polar format algorithm (PFA) for the spotlight synthetic aperture radar (SAR) image formation can be normally divided into two cascaded processing stages, which are called the range and azimuth resampling, respectively. This paper focuses on a new implementation of the first stage, i.e., the range resampling, using the chirp z-transform (CZT). The presented algorithm requires no interpolation. It works for the SAR system directly digitizing the echo signal, as well as that employing the dechirp-on-receive approach. The parameters of the CZT, including the frequency spacing and the start frequency, are derived to accommodate the PFA in both cases. Related filtering and compensation procedures are developed for the chirp z-transformed range signal with and without dechirp, respectively, in order to achieve a signal format entirely suitable for the azimuth resampling. Furthermore, incorporating the new algorithm with the existing CZT-based azimuth resampling and focusing algorithm, we can achieve a PFA totally free of interpolation. The presented approach has been validated by point target simulation, and the test is carried out with a very critical relative bandwidth of 30%
ISIS (2004)

ISIS (Intelligent Speech for Information Systems) is a trilingual spoken dialog system (SDS) for the stocks domain. It handles two dialects of Chinese (Cantonese and Putonghua) as well as English---the predominant languages in our region. The system supports spoken language queries regarding stock market information and simulated personal portfolios. The conversational interface is augmented with a screen display that can capture mouse-clicks as well as textual input by typing or stylus-writing. Real-time information is retrieved directly from a dedicated Reuters satellite feed. ISIS provides a system test-bed for our work in multilingual speech recognition and generation, speaker authentication, language understanding and dialog modeling. This article reports on our new explorations within the context of ISIS, including: (i) adaptivity to knowledge scope expansion; (ii) asynchronous human-computer interaction by task delegation to software agents; (iii) multi-threaded online interaction and offline delegation dialogs with interruptions for task switching.
Learning sparsifying transforms for image processing (2012)

The sparsity of signals and images in a certain analytically defined transform domain or dictionary such as discrete cosine transform or wavelets has been exploited in many applications in signal and image processing. Recently, the idea of learning a dictionary for sparse representation of data has become popular. However, while there has been extensive research on learning synthesis dictionaries, the idea of learning analysis sparsifying transforms has received only little attention. We propose a novel problem formulation and an alternating algorithm for learning well-conditioned square sparsifying transforms from data. We show the superiority of our approach for image representation over analytical sparsifying transforms such as the DCT. We also show promise in image denoising. Denoising using the learnt analysis transforms is not only better than by synthesis dictionaries learnt using the K-SVD algorithm but also faster.
THE CARDIOVASCULAR EFFECTS OF CRANIALLY-IMPRESSED ELECTRIC CURRENTS OF ANESTHETIC INTENSITY (1964)

WOOD, WILLIAM B. Ph.D.; POWERS, MARVIN F. Ph.D.; DORNETTE, W. H. L. M.D.; PRICE, JAMES M.D. Author Information
Myristoylation Restricts Orientation of the GRASP Domain on Membranes and Promotes Membrane Tethering (2014)

The mammalian Golgi reassembly stacking protein (GRASP) proteins are Golgi-localized homotypic membrane tethers that organize Golgi stacks into a long, contiguous ribbon-like structure. It is unknown how GRASPs undergo trans pairing given that cis interactions between the proteins in the plane of the membrane are intrinsically favored. To test the hypothesis that myristoylation of the self-interacting GRASP domain restricts its orientation on the membrane to favor trans pairing, we established an in vitro assay that recapitulates GRASP-dependent membrane tethering and used neutron reflection under similar conditions to determine the orientation of the GRASP domain. In vivo, the membrane association of GRASP proteins is conferred by the simultaneous insertion of an N-terminal myristic acid and binding to a Golgi-associated binding partner. In our assay, the latter contact was replaced using a C-terminal hexa-His moiety, which bound to Ni(2+)-conjugated lipids incorporated into a substrate-supported bilayer lipid membrane. Nonmyristoylated protein lacked a fixed orientation on the membrane and inefficiently tethered liposomes. In contrast, myristoylated GRASP promoted tethering and exhibited a unique membrane complex. Thus, myristoylation restricts the membrane orientation of the GRASP domain favoring interactions in trans for membrane tethering.
Targeted <i>ex vivo</i> reduction of CD64‐positive monocytes in chronic myelomonocytic leukemia and acute myelomonocytic leukemia using human granzyme B‐based cytolytic fusion proteins (2014)

CMML (chronic myelomonocytic leukemia) belongs to the group of myeloid neoplasms known as myelodysplastic and myeloproliferative diseases. In some patients with a history of CMML, the disease transforms to acute myelomonocytic leukemia (AMML). There are no specific treatment options for patients suffering from CMML except for supportive care and DNA methyltransferase inhibitors in patients with advanced disease. New treatment strategies are urgently required, so we have investigated the use of immunotherapeutic directed cytolytic fusion proteins (CFPs), which are chimeric proteins comprising a selective domain and a toxic component (preferably of human origin to avoid immunogenicity). The human serine protease granzyme B is a prominent candidate for tumor immunotherapy because it is expressed in cytotoxic T lymphocytes and natural killer cells. Here, we report the use of CD64 as a novel target for specific CMML and AMML therapy, and correlate CD64 expression with typical surface markers representing these diseases. We demonstrate that CD64‐specific human CFPs kill CMML and AMML cells ex vivo , and that the mutant granzyme B protein R201K is more cytotoxic than the wild‐type enzyme in the presence of the granzyme B inhibitor PI9. Besides, the human CFP based on the granzyme B mutant was also able to kill AMML or CMML probes resistant to Pseudomonas exotoxin A.
The human brain: localized H-1 MR spectroscopy at 1.0 T. (1990)

Localized H-1 magnetic resonance (MR) spectroscopy of the human brain in vivo was performed at a field strength of 1.0 T. Investigations with the stimulated echo acquisition mode included studies in the right frontoparietal area, occipital lobe, cerebellum, and pons of healthy volunteers, as well as studies in two patients with astrocytomas. Prior to the acquisition of the H-1 MR spectra, all examinations included fast low angle shot MR imaging in three orientations to select the volumes of interest. The tumor spectra confirmed previous findings at higher field strengths by producing characteristic alterations from the spectra of normal brain tissue: markedly reduced resonances of N-acetyl-aspartate and creatine, increased signal intensities of cholines, and a strong resonance from lactate. The authors conclude that the results of this study clearly demonstrate the feasibility of H-1 MR spectroscopy at 1.0 T without significant losses in relative spectral resolution and signal-to-noise ratio of major metabolites with singlet resonances, compared with previous studies at 1.5 and 2.0 T.
Multiple Cutaneous Myxomas Coinciding with Repeated Cardiac Myxomas. A Syndrome (1989)

We report on a 31-year-old woman who underwent surgery for two metachronous cardiac myxomas - 7 and 9 years after excision of several cutaneous myxomas. Our observation is a further case of a syndrome-like complex of cardiac and cutaneous myxoma(s), pigmentation anomalies and endocrine disorders described only recently. As modern investigative methods and the development of cardiovascular surgery have brought about an essential improvement in diagnostics and prognosis of cardiac myxomas, the knowledge of this syndrome-like complex is of great therapeutic importance. Therefore, in our opinion, echocardiographic investigations are strongly recommended even in asymptomatic patients, once several cutaneous myxomas are diagnosed histologically.
Polymer-Additive Extraction via Pressurized Fluids and Organic Solvents of Variously Cross-Linked Poly(methylmethacrylates) (2002)

Variously cross-linked poly(methylmethacrylates) (PMMAs) are synthesized with three additives incorporated at theoretically 1000 microg of the additive per gram of prepared polymer. The additives are Irganox 1010, Irganox 1076, and Irgafos 168. The in-house" synthesized polyacrylates are then subjected to supercritical fluid extraction (SFE) to determine if additive recovery is a function of percent cross-linking. Although considerable work in this regard has been performed with non-cross-linked polyolefins, the literature is lacking regarding polyacrylates. Some additive degradation apparently occurs during the synthesis, as judged by the increased complexity of the extract high-performance liquid chromatographic trace and the low percent recoveries observed especially for the Irganoxes. For low polymer cross-linking (1%), it appears that both PMMA synthetic reproducibility and readily observed polymer swelling during SFE are serious issues that adversely affect additive percent recovery and precision of results. Higher percent cross-linking yields more consistent analytical data than low percent cross-linking, even though the amount of additive extracted in all PMMA samples (regardless of cross-linking percentage) is essentially the same whether the extraction is via SFE or liquid-solid extraction with methylene chloride. Results for comparably cross-linked poly(ethylmethacrylate) and poly(butylmethacrylate) are similar to PMMA.
Practical Guide to Modern Hematology Analyzers (1995)

History of Cell Counting Cell Counting Technology Fundamentals Description of Modern Systems Standardization Performance of Modern Systems Integration into the Laboratory Future Developments.
Lentiviral Vectors for Gene Therapy of Cystic Fibrosis (1997)

A replication-defective vector based on human immunodeficiency virus (HIV) was evaluated for gene transfer directed to the lung. The tropism of this vector has been expanded through the incorporation of the vesticular stomatitis virus G protein into its envelope. The HIV vector effectively transduced nondividing airway epithelial cells in vitro whereas a murine-based retroviral vector did not. Experiments in a human bronchial xenograft model demonstrated high-level gene transduction with a cystic fibrosis transmembrane conductance regulator (CFTR) HIV vector into undifferentiated, cystic fibrosis (CF)-derived cells of the xenograft. CFTR expression was stable and capable of functional correction of the CF defect after the graft matured. The HIV vector did not effectively transduce cells of the xenograft when instilled after the epithelium had differentiated. This block to transduction appears to be at the level of entry, although post entry restrictions cannot be ruled out. Further development of this vector system for CF gene therapy should focus on a better understanding of potential entry and post entry blocks.
Notch3 marks clonogenic mammary luminal progenitor cells in vivo (2013)

The identity of mammary stem and progenitor cells remains poorly understood, mainly as a result of the lack of robust markers. The Notch signaling pathway has been implicated in mammary gland development as well as in tumorigenesis in this tissue. Elevated expression of the Notch3 receptor has been correlated to the highly aggressive "triple negative" human breast cancer. However, the specific cells expressing this Notch paralogue in the mammary gland remain unknown. Using a conditionally inducible Notch3-CreERT2(SAT) transgenic mouse, we genetically marked Notch3-expressing cells throughout mammary gland development and followed their lineage in vivo. We demonstrate that Notch3 is expressed in a highly clonogenic and transiently quiescent luminal progenitor population that gives rise to a ductal lineage. These cells are capable of surviving multiple successive pregnancies, suggesting a capacity to self-renew. Our results also uncover a role for the Notch3 receptor in restricting the proliferation and consequent clonal expansion of these cells.