gebhart/patrepeval huggingface dataset:
Online capacitance estimation of DC-link electrolytic capacitors for three-phase AC/DC/AC PWM converters using recursive least squares method (2005)

A novel online capacitance estimation method for a DC-link capacitor in a three-phase AC/DC/AC PWM converter is prepared. At no load, a controlled AC current with a lower frequency than the line frequency is injected into the input side, which then causes AC voltage ripples at the DC output side. By extracting the AC voltage and current components on the DC output side using digital filters, the capacitance can then be calculated using the recursive least squares method. The proposed method can be simply implemented with only software and no additional hardware. Experimental results confirm that the estimation error is less than 0.26%.
Functional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptides (2012)

These findings suggest that Aβ modulation of cholinergic signaling in hippocampal GABAergic interneurons via α7β2-nAChRs could be an early and critical event in Aβ-induced functional abnormalities of hippocampal function, which may be relevant to learning and memory deficits in AD.
Viable adenovirus vaccine prototypes: High-level production of a papillomavirus capsid antigen from the major late transcriptional unit (2005)

Safe, effective, orally delivered, live adenovirus vaccines have been in use for three decades. Recombinant derivatives of the live adenovirus vaccines may prove an economical alternative to current vaccines for a variety of diseases. To explore that possibility, we constructed a series of recombinants that express the major capsid protein (L1) of canine oral papillomavirus (COPV), a model for mucosal human papillomavirus (HPV) infection. Vaccination with virus-like particles (VLPs) composed of recombinant HPV L1 completely prevents persistent HPV infection [Koutsky, L. A., Ault, K. A., Wheeler, C. M., Brown, D. R., Barr, E., Alvarez, F. B., Chiacchierini, L. M. & Jansen, K. U. (2002) N. Engl. J. Med. 347, 1645-1651], suggesting that L1 expressed from recombinant adenoviruses might provide protective immunity. In our recombinants, COPV L1 is incorporated into adenovirus late region 5 (Ad L5) and is expressed as a member of the adenoviral major late transcriptional unit (MLTU). COPV L1 production by the most prolific recombinant is comparable to that of the most abundant adenoviral protein, hexon. COPV L1 production by recombinants is influenced by Ad L5 gene order, the specific mRNA processing signals associated with COPV L1, and the state of a putative splicing inhibitor in the COPV L1 gene. Recombinant COPV L1 protein assembles into VLPs that react with an antibody specific for conformational epitopes on native COPV L1 protein that correlate with protection in vivo. The designs of these recombinants can be applied directly to the production of recombinants appropriate for assessing immunogenicity and protective efficacy in animal models and in human trials.
Analysis and comparison of nucleotide sequences encoding the genes for [NiFe] and [NiFeSe] hydrogenases from Desulfovibrio gigas and Desulfovibrio baculatus (1989)

The nucleotide sequences encoding the [NiFe] hydrogenase from Desulfovibrio gigas and the [NiFeSe] hydrogenase from Desulfovibrio baculatus (N.K. Menon, H.D. Peck, Jr., J. LeGall, and A.E. Przybyla, J. Bacteriol. 169:5401-5407, 1987; C. Li, H.D. Peck, Jr., J. LeGall, and A.E. Przybyla, DNA 6:539-551, 1987) were analyzed by the codon usage method of Staden and McLachlan. The reported reading frames were found to contain regions of low codon probability which are matched by more probable sequences in other frames. Renewed nucleotide sequencing showed the probable frames to be correct. The corrected sequences of the two small and large subunits share a significant degree of sequence homology. The small subunit, which contains 10 conserved cysteine residues, is likely to coordinate at least 2 iron-sulfur clusters, while the finding of a selenocysteine codon (TGA) near the 3' end of the [NiFeSe] large-subunit gene matched by a regular cysteine codon (TGC) in the [NiFe] large-subunit gene indicates the presence of some of the ligands to the active-site nickel in the large subunit.
Safeguards against pathogens in danish biogas plants (1994)

A veterinary research project is organized in Danish biogas plants (BGP) to study the ‘pathogen reducing effect’ (PRE) of the treatment in digestion tanks and sanitation tanks, and the ‘pathogen reducing capacity’ (PRC) of the entire plant. In addition the feasibility of measures to prevent spread of animal and human pathogens is studied. Ten BGPs are currently in operation closely related to the agricultural sector. Slurry constitutes 80-85% of the biomass treated, various industrial by-products and urban waste the rest. Rules have been issued to prevent spread of pathogens between animal holdings during the collection, transport and distribution of biomass. Criteria for the treatment in digestion tanks and sanitation tanks have been introduced to ensure removal of pathogens. Official regulations on hygienic measures and conditions for treatment of biomass which is spread on agricultural land are included in Danish legislation. An indicator method based on faecal enterococci (streptococci) (FE) has proven its practical value for checking the functions, detecting leakage or wrong management, and for evaluating the PRE at temperatures below 55 to 60°C. Studies of the persistence of pathogens in biomass at higher temperatures are in progress. The role of the competent central, regional and local authorities for approval, regular supervision and inspection of the BGPs is described. The Veterinary Service takes action when outbreaks of serious diseases occur.
Defect centers in a-SiNx: electronic and structural properties (2002)

By combining ab initio methods and interatomic potentials, we investigated the electronic and the structural properties of amorphous silicon nitride. Our results show the trends on the electronic band structure of SiNx (0.5 < x < 1.8) as the nitrogen content changes, and are in good agreement with the experimental data.Hydrogenation of the systems was found to considerably reduce the number of energy levels in the gap. The energy levels which appeared in the materials band gap were compared to the electrically active centers, which have been identified by electron-paramagnetic resonance experiments.
Interferon Induction by Glycyrrhizin and Glycyrrhetinic Acid in Mice (1982)

Licorice extract is an herbal drug which has long been used as a demulcent and elixir in Chinese medicine. One of the main active components of licorice extract is glycyrrhizin (GL), a kind of saponin. The biological effects of GL and its aglycone, glycyrrhetinic acid (GA), have been extensively studied. Their anti-inflammatory (5), anti-ulcerous (3), and antiviral ( Moreover, a preparation of GL combined with glycine and cysteine (SNMC), has been widely and successfully used in Japan as an antihepatitis drug (6, II, 19), although its mechanism of pharmacological action remains unclear.
Genomic analysis identifies association of <i>Fusobacterium</i> with colorectal carcinoma (2011)

The tumor microenvironment of colorectal carcinoma is a complex community of genomically altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each of these components may contribute to carcinogenesis; however, the role of the microbiota is the least well understood. We have characterized the composition of the microbiota in colorectal carcinoma using whole genome sequences from nine tumor/normal pairs. Fusobacterium sequences were enriched in carcinomas, confirmed by quantitative PCR and 16S rDNA sequence analysis of 95 carcinoma/normal DNA pairs, while the Bacteroidetes and Firmicutes phyla were depleted in tumors. Fusobacteria were also visualized within colorectal tumors using FISH. These findings reveal alterations in the colorectal cancer microbiota; however, the precise role of Fusobacteria in colorectal carcinoma pathogenesis requires further investigation.
Strict Requirement for Vector-Induced Type I Interferon in Efficacious Antitumor Responses to Virally Encoded IL12 (2014)

Host responses are increasingly considered important for the efficacious response to experimental cancer therapies that employ viral vectors, but little is known about the specific nature of host responses required. In this study, we investigated the role of host type I interferons (IFN-I) in the efficacy of virally delivered therapeutic genes. Specifically, we used a Semliki Forest virus encoding IL12 (SFV-IL12) based on its promise as an RNA viral vector for cancer treatment. Intratumoral injection of SFV-IL12 induced production of IFN-I as detected in serum. IFN-I production was abolished in mice deficient for the IFNβ transcriptional regulator IPS-1 and partially attenuated in mice deficient for the IFNβ signaling protein TRIF. Use of bone marrow chimeric hosts established that both hematopoietic and stromal cells were involved in IFN-I production. Macrophages, plasmacytoid, and conventional dendritic cells were each implicated based on cell depletion experiments. Further, mice deficient in the IFN-I receptor (IFNAR) abolished the therapeutic activity of SFV-IL12, as did a specific antibody-mediated blockade of IFNAR signaling. Reduced efficacy was not caused by an impairment in IL12 expression, because IFNAR-deficient mice expressed the viral IL12 transgene even more strongly than wild-type (WT) hosts. Chimeric host analysis for the IFNAR involvement established a strict requirement in hematopoietic cells. Notably, although tumor-specific CD8 T lymphocytes expanded robustly after intratumoral injection of WT mice with SFV-IL12, this did not occur in mice where IFNAR was inactivated genetically or pharmacologically. Overall, our results argued that the antitumor efficacy of a virally based transgene therapeutic relied strongly on a vector-induced IFN-I response, revealing an unexpected mechanism of action that is relevant to a broad array of current translational products in cancer research.
2270. Initial Treatment Selection Among Patients with Recurrent Pseudomonas aeruginosa (PSA) Infections (Infxs): Does Prior PSA Antibiotic Susceptibility Results Effect Subsequent Empiric Treatment Decisions? (2019)

Abstract Background Resistance to commonly used anti-pseudomonal β-lactams (AP-BLs) like piperacillin/tazobactam (TZP), meropenem (MER) and cefepime (CEF) among patients (patients) with PSA infx is increasing. To minimize receipt of DAT among patients with PSA infxs, clinicians need to consider the patient’s risk of having a PSA infx that is NS to commonly used AP-BLs. A well-described risk factor for having a NS AP-BL PSA infx is recent history of an NS AP PSA infx. This study evaluates the likelihood that a patient with a PSA infx receives an AP-BL that was found to be NS on a prior PSA culture. Methods This was a multi-center (n = 239), retrospective cohort analysis using the 2018 data from the BD Insights Research Database (Becton, Dickinson and Company). Inclusion criteria: age ≥ 18 years; hospitalized; PSA infx (index PSA infx); occurrence of a PSA infx ≤ 1 year of index PSA infx (post-index PSA infx); and received treatment for the post-index PSA infx for ≥ 24 hours. Frequency of NS to ≥ 1 AP-BL (MER, TZP, or CEF) for the index PSA infxs was calculated. Among patients with an index PSA infx that was NS ≥ 1 AP-BL, the number of patients who received an AP-BL for the post-index PSA infx that was NS on the index PSA infx was determined. Results During study period, 16,062 patients had a PSA infx and 2,386 (14.9%) of patients had a post-index PsA infx. The most common culture sites for the index and post-index PSA infxs were respiratory and urine. The most commonly prescribed AP-BL for the post-index PSA infx were TZP (41.9%), CEF (40.3%), and MER (30.8%). In total, 1,026 (43%) of patients had an index PSA infx that was NS to ≥1 AP-BL. Among the 1,026 patients with an index PSA infx that was NS to ≥1 AP-BL, 902 (88%) patients received an AP-BL as initial therapy for the post-index PSA infx and 558 (62%) patients received an AP-BL that was reported as NS on the index PSA culture. Conclusion The findings highlight the importance of considering prior PSA culture and susceptibility data when selecting initial antibiotic therapy for patients who present with a suspected or documented PSA infx and have a history of a prior PSA infx. Patients with history of a PsA infx that was NS to ≥1 AP-BL may benefit from initial use of novel AP-BL therapies. Disclosures All authors: No reported disclosures.
Surface-acoustic-wave devices with low sensitivity to mechanical and thermoelastic stresses. (1992)

Surface-acoustic-wave (SAW) devices with a low sensitivity to both temperature and stresses effects are presented and experimentally tested. Devices are built on SAW quartz cuts with zero first-order temperature coefficient and zero sensitivity to planar isotropic stresses. In comparison with similar devices built on conventional (ST, X) cuts, two kinds of experiments are reported. First, devices built on circular quartz plates are submitted to in-plane diametrical compressions. The force-frequency effect is measured and results are compared to theoretical predictions either by analytical models or using finite element analysis. In a second experiment, the same devices are submitted to in-plane thermoelastic stresses in a dynamical thermal regime. It is shown that the sensitivity of the new cuts to dynamical thermal effects is one order of magnitude lower than the conventional (ST, X) cut, an attractive potentiality for fast-warm-up high-stability SAW oscillators in severe environmental conditions.
A test battery of bacterial toxicity assays and comparison with LD<sub>50</sub> values (1989)

Abstract The toxicity of some mycotoxins, lactones and dicarboxylic anhydrides, insecticides, herbicides, and fungicides can be detected by means of bacterial assays. In addition, the order of magnitude of the toxicity can also be evaluated. Fifty‐eight chemicals as well as extracts of peanuts, apple juices, and grains have been investigated in a test battery of three different kinds of assays. In cup plate diffusion assays a minimal amount of approximately 0. 1 mg/mL of mycotoxin may be detected by means of growth inhibition assays with Bacillus thuringiensis on one hand, and pigment synthesis inhibition assays with mutants of Serratia marcescens on the other hand. Swarming inhibition assays with the motile strains Azospirillum brasilense and Proteus mirabilis show the same sensitivity. Comparisons of our test battery with other bioassays, as well as with mammalian toxicity tests (LD 50 values), reveal correlations between these kinds of assays in regard to the test substances.
Quantification of coronary artery Stenosis by Area Stenosis from cardiac CT angiography (2015)

Non-invasive cardiac computed tomography angiography (CTA) is widely used to assess coronary artery stenosis and give clinical decision-making support to clinicians. The severity of stenosis lesion is commonly graded by a range of percent Diameter Stenosis (DS), which can introduce false positive diagnoses or over-estimation, triggering unnecessary further procedures. In this paper, a system and the associate methods to quantify stenosis by the percent Area Stenosis (AS) from cardiac CTA is presented. In the process, coronary artery tree is segmented and the centerline is extracted by Hessian filtering and the minimal path method. After a serial of 2D cross-sectional artery images along the artery centerline are obtained, lumen areas are segmented by ellipse-fitting with deformable models, and consequently to compute the lesion's AS. Experimental results on 5 CTA data sets show that compared to DS, AS better correlates to the reference standard for stenosis quantification, suggesting the efficacy of the proposed system.
Physical stability of dry powder inhaler formulations (2019)

<b>Introduction</b>: Dry powder inhalers (DPIs) are popular for pulmonary drug delivery. Various techniques have been employed to produce inhalation drug particles and improve the delivery efficiency of DPI formulations. Physical stability of these DPI formulations is critical to ensure the delivery of a reproducible dose to the airways over the shelf-life.<b>Areas covered</b>: This review focuses on the impact of solid-state stability on aerosolization performance of DPI drug particles manufactured by powder production approaches and particle-engineering techniques. It also highlights the different analytical tools that can be used to characterize the physical instability originating from production and storage.<b>Expert opinion</b>: A majority of the DPI literature focuses on the effects of physico-chemical properties such as size, morphology, and density on aerosolization. While little has been reported on the physical stability, particularly the stability of engineered drug particles for use in DPIs. Literature data have shown that different particle-engineering methods and storage conditions may cause physical instability of dry powders for inhalation and can significantly change the aerosol performance. A systematic examination of physical instability mechanisms in DPI formulations is necessary during formulation development in order to select the optimum formulation with satisfactory stability. In addition, the use of appropriate characterization tools is critical to detect and understand physical instability during the development of DPI formulations.
Pentacoordinate Silicon Derivatives. II.<sup>1</sup> Salts of Bis(<i>o</i>-arylenedioxy) organosiliconic Acids (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPentacoordinate Silicon Derivatives. II.1 Salts of Bis(o-arylenedioxy) organosiliconic AcidsCecil L. FryeCite this: J. Am. Chem. Soc. 1964, 86, 15, 3170–3171Publication Date (Print):August 1, 1964Publication History Published online1 May 2002Published inissue 1 August 1964https://pubs.acs.org/doi/10.1021/ja01069a054https://doi.org/10.1021/ja01069a054research-articleACS PublicationsRequest reuse permissionsArticle Views773Altmetric-Citations90LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Small Molecule Activation of Procaspase-2 for the Selective Induction of Apoptotic Death in Breast Cancer Cells (2007)

Abstract : We have synthesized a library of compounds based on a previously identified procaspase-2 activator. These compounds were then tested for their ability to activate procaspase-2 in vitro. The results from these tests indicated that several of the compounds did indeed activate procaspase-2. Testing of these active compounds against a panel of enzymes then revealed, surprisingly, that the compounds are general enzyme activators. We have now explored this phenomena of general enzyme activation more thoroughly and have submitted a manuscript on the topic. The data and knowledge acquired through this work now allows us to move confidently to a high-throughput screen to identify truly specific procaspase-2 activators.
The Formation of Chlorine Pentafluoride in an Electrochemical Cell (1969)

Coulometric experiments undertaken with chlorine trifluoride in anhydrous hydrogen fluoride resulted in the formation of chlorine pentafluoride in a divided or an undivided electrolytic cell. The yields of chlorine pentafluoride, based on current, in the undivided and the divided cell were of the order of 25 and 50% respectively. Fluorine, nickel fluoride, and small quantities of chlorine‐oxygen‐fluorine compounds were also formed at the anode. At the cathode, hydrogen, hydrogen chloride, and chlorine were formed depending on the degree of mixing of anolyte and catholyte. Nickel electrodes were used almost exclusively; however, chlorine pentafluoride was also formed at a Glassy Carbon anode. The rate of formation of chlorine pentafluoride was found to be a function of the concentration of chlorine trifluoride in the electrolyte. From an analysis of polarization data, it was concluded that the mechanism involved the anodic oxidation of fluoride ion to some form of active fluorine, followed by its reaction with chlorine trifluoride to form chlorine pentafluoride.
Light Scattering By Polystyrene Spheres On A Mirror (1987)

Three models have been developed to describe light scattering from a sphere positioned on a mirror. The actual system is modeled as a two-sphere system consisting of a real and an imaginary sphere. Light scattering from each sphere is assumed to follow Mie theory. No further interaction is assumed between the sphere and the mirror. The models differ in their consideration of the interaction of scattered fields from the spheres. The results of the models are compared with experimental values with the size parameter 4.88 and 7.00 with s- and p-polarization. The comparison indicates that a best fit can be obtained by assuming the two spheres are coherent light sources with a phase difference ofπ.
Structure-Function Relationships of the Yeast Cyclin-Dependent Kinase Pho85 (1995)

The PHO85 gene of Saccharomyces cerevisiae encodes a cyclin-dependent kinase involved in both transcriptional regulation and cell cycle progression. Although a great deal is known concerning the structure, function, and regulation of the highly homologous Cdc28 protein kinase, little is known concerning these relationships in regard to Pho85. In this study, we constructed a series of Pho85-Cdc28 chimeras to map the region(s) of the Pho85 molecule that is critical for function of Pho85 in repression of acid phosphatase (PHO5) expression. Using a combination of site-directed and ethyl methanesulfonate-induced mutagenesis, we have identified numerous residues critical for either activation of the Pho85 kinase, interaction of Pho85 with the cyclin-like molecule Pho80, or substrate recognition. Finally, analysis of mutations analogous to those previously identified in either Cdc28 or cdc2 of Schizosaccharomyces pombe suggested that the inhibition of Pho85-Pho80 activity in mechanistically different from that seen in the other cyclin-dependent kinases.
Inland river ship supervision system based on ZigBee and RFID technology (2013)

In view of the current conditions that the network of rivers and the inland waterway in southeast coastal area are dense and numerous, a kind of inland ship monitoring system based on ZigBee networking system and RFID recognition technology is proposed by the author. Several advantages of nRF24LE1 SCM are given full play in this system, such as good anti-interference capability, high transmission stability and bulk-storage memory. By the high speed communication between the ZigBee network system and monitoring center, and also through the advantage of infinite extension of ZigBee network, several inland river ways can be covered. Many functions of inland river ways such as ship positioning and ship control are achieved through the comprehensive utilizations of RFID and ZigBee technology. The hardware management scheme of this system and the design flow of RFID and other related programs are described in detail in this paper.