gebhart/patrepeval huggingface dataset:
Macrophage Inflammatory Protein-2 Is Required for Neutrophil Passage Across the Epithelial Barrier of the Infected Urinary Tract (1999)

IL-8 is a major human neutrophil chemoattractant at mucosal infection sites. This study examined the C-X-C chemokine response to mucosal infection, and, specifically, the role of macrophage inflammatory protein (MIP)-2, one of the mouse IL-8 equivalents, for neutrophil-epithelial interactions. Following intravesical Escherichia coli infection, several C-X-C chemokines were secreted into the urine, but only MIP-2 concentrations correlated to neutrophil numbers. Tissue quantitation demonstrated that kidney MIP-2 production was triggered by infection, and immunohistochemistry identified the kidney epithelium as a main source of MIP-2. Treatment with anti-MIP-2 Ab reduced the urine neutrophil numbers, but the mice had normal tissue neutrophil levels. By immunohistochemistry, the neutrophils were found in aggregates under the pelvic epithelium, but in control mice the neutrophils crossed the urothelium into the urine. The results demonstrate that different chemokines direct neutrophil migration from the bloodstream to the lamina propria and across the epithelium and that MIP-2 serves the latter function. These findings suggest that neutrophils cross epithelial cell barriers in a highly regulated manner in response to chemokines elaborated at this site. This is yet another mechanism that defines the mucosal compartment and differentiates the local from the systemic host response.
State Regionalism in New Mexico (1937)

Journal Article State Regionalism in New Mexico Get access John C. Russell John C. Russell Syracuse University Search for other works by this author on: Oxford Academic Google Scholar Social Forces, Volume 16, Issue 2, December 1937, Pages 268–271, https://doi.org/10.2307/2570531 Published: 01 December 1937
Intra-operation Dynamic Voltage Scaling (2015)

Embedded peripheral devices are often specified with a range of performance characteristics that are determined by their supply voltage. Recent research explored the benefits of modulating peripheral supply voltage with task-level granularity. With Intra-Operation Dynamic Voltage Scaling (IODVS), we further reduce the energy consumption of peripheral devices by modulating the peripheral supply voltage at critical states occurring during operation of the peripheral device. IODVS is designed to have minimal impact on CPU utilization through the use of a lookup table that designates an ideal voltage on a per-state basis. IODVS is unique in that during high-performance states such as data-transmission, peripherals can have the high supply voltage required to reduce overall energy-delay product. Likewise, during low-performance states such as mandatory delays, the system decreases peripheral domain voltage thus reducing energy consumption without adversely affecting performance or correctness. We demonstrate this method on various peripherals common to wireless sensor nodes and have found total energy savings of up to 40%.
Biotransformation and Clearance of 3-(Phenylamino)propane-1,2-diol, a Compound Present in Samples Related to Toxic Oil Syndrome, in C57BL/6 and A/J Mice (1999)

In May 1981, a massive food-borne intoxication occurred in Spain. The so-called toxic oil syndrome (TOS) was associated with the consumption of aniline-denatured and refined rapeseed oil that was illegally sold as edible olive oil. Fatty acid anilides and fatty acid derivatives of 3-(phenylamino)propane-1,2-diol were detected in oils and implicated as potential toxic agents and markers of toxic oil batches. Epidemiological evidence points to 3-(phenylamino)propane-1,2-diol derivatives as the putative toxic agents, which were generated during the refining process at the ITH refinery. Here we present the biotransformation and clearance of 3-(phenylamino)propane-1,2-diol (PAP) administered intraperitoneally to A/J and C57BL/6 mice that have been proposed as a murine model for the immunological features of TOS. Mice eliminated 6 microCi of [U-(14)C]PAP during a 24 h period, mostly in urine. Animals exhibited urine elimination rates of 70 and 36% in A/J and C57BL/6 strains, respectively. A/J mice exhibited no increase in the elimination rate when induced with beta-naphthoflavone, whereas C57BL/6 did increase the rate of elimination to 57%. Feces contributed to a lesser extent to the elimination rate (0.6 and 3.3% in A/J and C57BL/6 mice, respectively). Radioactivity remaining in organ tissues was lower than 1% (liver, lung, kidney, spleen, heart, and muscle). Metabolic species in urine were identified by HPLC coupled to UV and radioisotope detectors and further GC/MS analyses. 2-Hydroxy-3-(phenylamino)propanoic acid metabolite was the major chemical species excreted in urine in both strains, in both control and induced animal groups. This compound was the main urinary metabolite of PAP, and unmetabolized PAP excreted in urine constituted less than 1% of the total administered dose. Two additional highly polar metabolites also detected in urine were identified as 3-[(4'-hydroxyphenyl)amino]propane-1,2-diol and 2-hydroxy-3-[(4'-hydroxyphenyl)amino]propanoic acid. These findings are the first reported on PAP metabolism and clearance in mice strains and suggest that PAP can be extensively metabolized in vivo and potential reactive species can be generated.
How Do Emulsions Evaporate? (2002)

Evaporation rates of water and oil from creamed oil-in-water emulsions have been measured under conditions of controlled gas flow. The continuous water phases of the emulsions evaporate at rates equal to that for pure water under the same conditions. The evaporation rates of dispersed oil drops are retarded, relative to nonemulsified oil, by factors ranging from 1 to 20. Rates for different emulsified oils are all consistent with a mechanism in which the oil drops remain separated from the vapor phase by a thin water film at the emulsion surface. Oil transport from the drops to the vapor occurs by diffusion of dissolved oil across this water film. Measured evaporation rates show good agreement with model calculations based on this proposed mechanism.
Acetoin production by wild-type strains and a lactate dehydrogenase-deficient mutant of Streptococcus mutans (1987)

Eleven different laboratory strains of Streptococcus mutans representing the various serogroups were found to produce an average of 6.0 +/- 4.8 mM acetoin when grown in glucose-containing medium under aerobic conditions. None of the strains produced detectable acetoin when grown anaerobically. A lactate dehydrogenase-deficient mutant produced acetoin both aerobically and anaerobically and in substantially greater amounts than the wild-type strains did. Substitution of mannitol for glucose resulted in decreased acetoin production by wild-type strains and the lactate dehydrogenase-deficient mutant, indicating a role for NADH2 in the regulation of the acetoin pathway. Pyruvate incorporated into the growth medium of a wild-type strain caused acetoin to be produced anaerobically and stimulated acetoin production aerobically. Cell extracts of a wild-type S. mutans strain were capable of producing acetoin from pyruvate and were (partly) dependent on thiamine PPi. Extracts prepared from aerobically grown cells had approximately twice the acetoin-producing activity as did extracts prepared from anaerobically grown cells. The results indicate that acetoin production by S. mutans may represent an auxiliary reaction of pyruvate dehydrogenase in this organism.
The enhancement of radiotherapy verification images by an automated edge detection technique (1992)

Adaptive histogram equalization techniques are known to be effective for the enhancement of contrast in portal images acquired during radiotherapy treatments. A significant drawback is the loss of definition on the edges of the treatment field. Analysis of this problem shows that it can be remedied by separating the treatment field from the background prior to the enhancement, and using only the pixels within the field boundary in the enhancement procedure. An edge extraction algorithm has been developed for delineating the treatment field in portal images, and consists of four modules that are applied to the original portal image in sequence. In the first step, edges are enhanced with a derivative of Gaussian operator that assures high response to the field edges relative to anatomical or other edges in the image. Pixels for which the response of the edge operator was the strongest are subsequently connected by an edge following algorithm to produce a raw contour of the field. In the last two steps the contour is refined by converting it into straight line segments and appending to the contour any parts of the field edge that might have been missed out during the initial edge following. The final contour encloses exclusively those pixels that belong to the treatment field, and the adaptive histogram equalization is applied selectively to this region. The combination of edge detection and selective enhancement was shown to produce images of superior contrast on the patient's anatomical features as well as accurate definition of treatment field edges.
10.1016/s0967-0653(98)84760-1 (2000)

The sedimentation of spheres in a Newtonian fluid is experimentally studied under creeping flow conditions. The mean particle settling velocity and the particle velocity fluctuations are measured across the width of the sedimentation cell. We show that there can be a global intrinsic convection of the suspension superimposed on the settling motion of the particles. Unlike the predictions of the dilute theories of intrinsic convection, this effect is found to be small and even to disappear with increasing concentrations. We also find that there is an ordering of the suspension near the wall, which may be responsible for the observed small magnitude of the convection.
Pyrrolidine Sugars. Synthesis of 4'-Acetamidoadenosine and Other Derivatives of 4-Amino-4-deoxy-D-ribose<sup>1</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrrolidine Sugars. Synthesis of 4'-Acetamidoadenosine and Other Derivatives of 4-Amino-4-deoxy-D-ribose1Elmer J. Reist, Donald E. Gueffroy, Robert W. Blackford, and Leon GoodmanCite this: J. Org. Chem. 1966, 31, 12, 4025–4030Publication Date (Print):December 1, 1966Publication History Published online1 May 2002Published inissue 1 December 1966https://doi.org/10.1021/jo01350a033RIGHTS & PERMISSIONSArticle Views217Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (910 KB) Get e-Alerts Get e-Alerts
γ-Secretase Activity Is Associated with a Conformational Change of Nicastrin (2003)

Gamma-secretase is a high molecular weight multicomponent protein complex with an unusual intramembrane-cleaving aspartyl protease activity. Gamma-secretase is intimately associated with Alzheimer disease because it catalyzes the proteolytic cleavage, which leads to the liberation of amyloid beta-peptide. At least presenilin (PS), Nicastrin (Nct), APH-1, and PEN-2 are constituents of the gamma-secretase complex, with PS apparently providing the active site of gamma-secretase. Expression of gamma-secretase complex components is tightly regulated, however little is known about the assembly of the complex. Here we demonstrate that Nct undergoes a major conformational change during the assembly of the gamma-secretase complex. The conformational change is directly associated with gamma-secretase function and involves the entire Nct ectodomain. Loss of function mutations generated by deletions failed to undergo the conformational change. Furthermore, the conformational alteration did not occur in the absence of PS. Our data thus suggest that gamma-secretase function critically depends on the structural "activation" of Nct.
THE REACTIVITY OF PARA-FLUORINE IN TRIARYLMETHYL CHLORIDES (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleTHE REACTIVITY OF PARA-FLUORINE IN TRIARYLMETHYL CHLORIDESFRANK BACON and JOHN H. GARDNERCite this: J. Org. Chem. 1938, 03, 3, 281–286Publication Date (Print):July 1, 1938Publication History Published online1 May 2002Published inissue 1 July 1938https://pubs.acs.org/doi/10.1021/jo01220a011https://doi.org/10.1021/jo01220a011research-articleACS PublicationsRequest reuse permissionsArticle Views121Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Determination of quality in surface water and open well water around industrial park Special Economic Zone of Mambattu (SPSR Nellore District), A.P. India. (2012)

This study was conducted to analysis various water samples of SEZ of Mambattu, Tada mandal, SPSR Nello re district and assess the possible impacts of such e ffluents on quality of open well water and surface water. A total of 10 samples including 5 from surface water (surround ing industries leather ,power, steel, electronics, chemical, matrices, etc.), and 5 from open well water of all bore wells in the vicinity of the SEZ were collect ed in November 2011, the samples in the SEZ of mambattu, the indus try like leather, Power, Steel, Electronics, Chemic als, Matrices are located were analyzed for various physico chemi cal parameters like temperature, pH, EC,DO, Total H ardness, BOD,COD,TDS, Sulphates, Nitrates, Chloridres and he avy metals like Fe, Pb, Zn, Mn, Cd .The results wer e compared with US EPA and WHO standards for both su rface and open well water collected from above said area. All physicochemical parameters are within the permi ssible limit except Fe concentrations which were fo und above the permissible limit.
Investigation of SSR in Practical DFIG-Based Wind Farms Connected to a Series-Compensated Power System (2014)

Subsynchronous resonance (SSR) was observed in wind farms located in North China. These wind farms prevailingly consist of doubly-fed induction generators (DFIGs) and are connected to series-compensated transmission lines. The observed resonant frequency is about 6 ~ 8 Hz, which is much lower than that of the reported SSR occurred in Texas. The frequency varies during the occurrence and this phenomenon is observed for the first time. The output power is usually within a certain range, when SSR occurs. Based on the practical system, an equivalent simulation system has been established, in which wind farms are modeled as many identical low rating DFIGs. Then, the SSR event is reproduced by simulations. Analysis results indicate that SSR happens even when the equivalent transmission system compensation level seen from wind farms is only 6.67%. Eigenvalue analysis shows that this phenomenon is an electrical resonance, and could be affected considerably by wind speed, number and control of DFIGs. The number of in-service DFIGs has a nonlinear impact on the damping of SSR. An equivalent electric circuit is deduced to intuitively explain why SSR happens and how the above factors affect it. Considering its features, this phenomenon is recognized as DFIG control participated induction generator effect.
Multianalyte profiling of serum cytokines for detection of pancreatic cancer (2005)

Early detection of pancreatic cancer might improve clinical outcome. Significant alterations in the levels of individual serum cytokines have been reported in pancreatic cancer. We hypothesized that a multicytokine panel could serve as biomarkers for pancreatic cancer. To evaluate the diagnostic utility of such a panel, we have utilized a novel multianalyte LabMAP profiling technology that allows simultaneous measurement of multiple markers. In this study, a panel of 31 serological markers including cytokines, chemokines, growth and angiogenic factors in combination with CA 19-9 was analyzed in sera of pancreatic cancer patients, patients with chronic pancreatitis, and matched control healthy subjects. Statistical analysis identified a multicytokine panel that was able to distinguish pancreatic cancer from healthy controls with a sensitivity of 85.7% and specificity of 92.3%, which was superior to performance of CA 19-9 alone. Importantly, a multicytokine panel allowed the discrimination of pancreatic cancer from chronic pancreatitis with high sensitivity of 98% and specificity of 96.4%. In conclusion, we demonstrated that analysis of multiple serum cytokines using a novel LabMAP technology is a promising approach for development of a diagnostic assay for pancreatic cancer.
Rat brain vascular distribution of interleukin‐1 type‐1 receptor immunoreactivity: Relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli (2004)

Interleukin-1 beta (IL-1 beta) is thought to act on the brain to induce fever, neuroendocrine activation, and behavioral changes during disease through induction of prostaglandins at the blood-brain barrier (BBB). However, despite the fact that IL-1 beta induces the prostaglandin-synthesizing enzyme cyclooxygenase-2 (COX-2) in brain vascular cells, no study has established the presence of IL-1 receptor type 1 (IL-1R1) protein in these cells. Furthermore, although COX inhibitors attenuate expression of the activation marker c-Fos in the preoptic and paraventricular hypothalamus after administration of IL-1 beta or bacterial lipopolysaccharide (LPS), they do not alter c-Fos induction in other structures known to express prostaglandin receptors. The present study thus sought to establish whether IL-1R1 protein is present and functional in the rat cerebral vasculature. In addition, the distribution of IL-1R1 protein was compared to IL-1 beta- and LPS-induced COX-2 expression. IL-1R1-immunoreactive perivascular cells were mostly found in choroid plexus and meninges. IL-1R1-immunoreactive vessels were seen throughout the brain, but concentrated in the preoptic area, subfornical organ, supraoptic hypothalamus, and to a lesser extent in the paraventricular hypothalamus, cortex, nucleus of the solitary tract, and ventrolateral medulla. Vascular IL-1R1-ir was associated with an endothelial cell marker, not found in arterioles, and corresponded to the induction patterns of phosphorylated c-Jun and inhibitory-factor kappa B mRNA upon IL-1 beta stimulation, and colocalized with peripheral IL-1 beta- or LPS-induced COX-2 expression. These observations indicate that functional IL-1R1s are expressed in endothelial cells of brain venules and suggest that vascular IL-1R1 distribution is an important factor determining BBB prostaglandin-dependent activation of brain structures during infection.
Spatial operator approach to flexible manipulator inverse and forward dynamics (2002)

This study extends to flexible multibody manipulators the recent results of the author (1989) on the use of spatially recursive filtering and smoothing techniques for robot arm dynamics. The configuration analyzed is that of a mechanical system of flexible bodies joined together by articulated joints. The inverse and forward dynamics problems are solved using the techniques of spatially recursive Kalman filtering and smoothing. The algorithms are easily developed using a set of identities associated with mass matrix factorization and inversion. The identities are easily derived using a spatial operator algebra developed by the author.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Motion-induced error compensation for phase shifting profilometry (2018)

This paper proposes a novel method to substantially reduce motion-introduced phase error in phase-shifting profilometry. We first estimate the motion of an object from the difference between two subsequent 3D frames. After that, by leveraging the projector's pinhole model, we can determine the motion-induced phase shift error from the estimated motion. A generic phase-shifting algorithm considering phase shift error is then utilized to compute the phase. Experiments demonstrated that proposed algorithm effectively improved the measurement quality by compensating for the phase shift error introduced by rigid and nonrigid motion for a standard single-projector and single-camera digital fringe projection system.
Caspase Substrates and Inhibitors (2013)

Caspases are proteases at the heart of networks that govern apoptosis and inflammation. The past decade has seen huge leaps in understanding the biology and chemistry of the caspases, largely through the development of synthetic substrates and inhibitors. Such agents are used to define the role of caspases in transmitting life and death signals, in imaging caspases in situ and in vivo, and in deconvoluting the networks that govern cell behavior. Additionally, focused proteomics methods have begun to reveal the natural substrates of caspases in the thousands. Together, these chemical and proteomics technologies are setting the scene for designing and implementing control of caspase activity as appropriate targets for disease therapy.
Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome (2007)

The hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment. Genetic studies demonstrate that heterozygous mutations of membrane cofactor protein (MCP;CD46) predispose to atypical HUS (aHUS), which is not associated with exposure to Shiga toxin (Stx). Among the initial 25 MCP mutations in patients with aHUS were 2, R69W and A304V, that were expressed normally and for which no dysfunction was found. The R69W mutation is in complement control protein module 2, while A304V is in the hydrophobic transmembrane domain. In addition to 3 patients with aHUS, the A304V mutation was identified in 1 patient each with fatal Stx-HUS, the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome, and glomerulonephritis with C3 deposits. A major goal was to assess if these putative mutations lead to defective complement regulation. Permanent cell lines expressing the mutated proteins were complement "challenged," and membrane control of C3 fragment deposition was monitored. Both the R69W and A304V MCP mutations were deficient in their ability to control the alternative pathway of complement activation on a cell surface, illustrating the importance of modeling transmembrane proteins in situ.