gebhart/patrepeval huggingface dataset:
On the electrical conductivity of microbial nanowires and biofilms (2011)

Dissimilatory metal-reducing bacteria (DMRB), such as Geobacter and Shewanella spp., occupy a distinct metabolic niche in which they acquire energy by coupling oxidation of organic fuels with reduction of insoluble extracellular electron acceptors (i.e., minerals). Their unique extracellular electron transfer (EET) capabilities extend to reduction of anodes (electrodes maintained at sufficiently positive potentials) on which they form persistent, electric current generating biofilms. One hypothesis describing the mechanism of EET by Geobacter and Shewanella spp. involves superexchange in which electrons are conducted by a succession of electron transfer reactions among redox proteins associated with the outer cell membranes, aligned along pilus-like filaments (e.g.pili), and/or throughout the extracellular matrix. Here we present theory, previously developed to describe superexchange within abiotic redox polymers, to describe superexchange within DMRB biofilms grown on anodes. We show that this theory appears to apply to recent ex situ measurements of electrical conductivity by individual pilus-like filaments of S. oneidensis MR-1 and G. sulfurreducensDL1, referred to as microbial nanowires. Microbial nanowires have received much recent attention because they are thought by some to impart electrical conductivity to DMRB biofilms and because of the prospect of microbe-produced conductive nanomaterials. We also show that this theory appears to apply to preliminary in situ demonstration of electrical conductivity of an anode-grown G. sulfurreducensDL1 biofilm. Based on these results we suggest a role for nanowires of S. oneidensis and G. sulfurreducens in biofilm conductivity.
The Display Text Editor TED: A Case Study in the Design and Implementation of Display-Oriented Interactive Human Interfaces (1982)

We present the criteria used in designing the human interface of the display text editor TED and explain how the design tradeoffs were made. Although discussed in the context of a text editor, these criteria are applicable to the design of human interfaces in general. We present a critical evaluation of the TED human interface in hindsight, and suggest modifications to overcome the shortcomings thus uncovered. The new interface is judged to be less obtrusive and more flexible than its earlier version. This process of design-implementation-evaluation is essential to learning how to build good human interfaces in the future. We describe the software architecture of TED and point out how the use of sound software engineering principles has yielded a program that is easy to modify and interface to a variety of I/O devices, namely, screens, keyboards, cursor pointing devices, and voice recognition units.
Recruitment of N-CoR/SMRT–TBLR1 Corepressor Complex by Unliganded Thyroid Hormone Receptor for Gene Repression during Frog Development (2004)

The corepressors N-CoR (nuclear receptor corepressor) and SMRT (silencing mediator for retinoid and thyroid hormone receptors) interact with unliganded nuclear hormone receptors, including thyroid hormone (T(3)) receptor (TR). Several N-CoR/SMRT complexes containing histone deacetylases have been purified. The best studied among them are N-CoR/SMRT complexes containing TBL1 (transducin beta-like protein 1) or TBLR1 (TBL1-related protein). Despite extensive studies of these complexes, there has been no direct in vivo evidence for the interaction of TBL1 or TBLR1 with TR or the possible involvement of such complexes in gene repression by any nuclear receptors in any animals. Here, we used the frog oocyte system to demonstrate that unliganded TR interacts with TBLR1 and recruits TBLR1 to its chromatinized target promoter in vivo, accompanied by histone deacetylation and gene repression. We further provide evidence to show that the recruitment of TBLR1 or related proteins is important for repression by unliganded TR. To investigate the potential role for TBLR1 complexes during vertebrate development, we made use of T(3)-dependent amphibian metamorphosis as a model. We found that TBLR1, SMRT, and N-CoR are recruited to T(3)-inducible promoters in premetamorphic tadpoles and are released upon T(3) treatment, which induces metamorphosis. More importantly, we demonstrate that the dissociation of N-CoR/SMRT-TBLR1 complexes from endogenous TR target promoters is correlated with the activation of these genes during spontaneous metamorphosis. Taken together, our studies provide in vivo evidence for targeted recruitment of N-CoR/SMRT-TBLR1 complexes by unliganded TR in transcriptional repression during vertebrate development.
The November Leonids, 1901 (1901)

Search Bar to Enter New Query quick field: Author First Author Abstract Year Fulltext Select a field or operator abstract abstract only acknowledgements affiliation arXiv category author count author bibcode bibliographic group bib abbrev, e.g. ApJ body of article data archive collection citation count doctype doi entdate first author fulltext identifier inst keyword object orcid page property publication full name date published title volume year citations() pos() references() reviews() similar() topn() trending() useful() single wildcard: ? wildcard: * exact match: = All Search Terms Your search returned 0 results Your search returned 0 results
FACADE (2015)

The past decade has witnessed the increasing demands on data-driven business intelligence that led to the proliferation of data-intensive applications. A managed object-oriented programming language such as Java is often the developer's choice for implementing such applications, due to its quick development cycle and rich community resource. While the use of such languages makes programming easier, their automated memory management comes at a cost. When the managed runtime meets Big Data, this cost is significantly magnified and becomes a scalability-prohibiting bottleneck. This paper presents a novel compiler framework, called Facade, that can generate highly-efficient data manipulation code by automatically transforming the data path of an existing Big Data application. The key treatment is that in the generated code, the number of runtime heap objects created for data types in each thread is (almost) statically bounded, leading to significantly reduced memory management cost and improved scalability. We have implemented Facade and used it to transform 7 common applications on 3 real-world, already well-optimized Big Data frameworks: GraphChi, Hyracks, and GPS. Our experimental results are very positive: the generated programs have (1) achieved a 3%--48% execution time reduction and an up to 88X GC reduction; (2) consumed up to 50% less memory, and (3) scaled to much larger datasets.
Effect of Sequence in Extraction of Trace Metals from Soils (1986)

Abstract While many workers have utilized various reagents for sequential extraction of soil trace metals, few studies have examined the order of extraction for key steps in the sequential procedure. In this study, several sequences involving both adsorbed and structural (occluded) metal extractants were evaluated to determine the most appropriate sequential methodology for extracting different forms of Cu, Fe, and Mn. For “specifically adsorbed” metals, Pb(NO 3 ) 2 and CH 3 COOH were used. The results showed that the former reagent extracted less Cu, Mn, and Fe and was probably more specific in replacing metals covalently bound to adsorption sites. Lead nitrate was therefore placed before CH 3 COOH extraction in the sequence. Chao's NH 2 OH·HCl reagent and K 4 P 2 O 7 , used for Mn oxide and organic metal removal, respectively, were found to solubilize significantly different amounts of Cu and Mn depending on sequence, with K 4 P 2 O 7 extracting more metal when used first. As NH 2 OH·HCl has little effect on organic metals, it should be used before K 4 P 2 O 7 . Noncrystalline and crystalline Fe compounds are solubilized next, using a variety of reagents, and residual (silicate lattice) metals are dissolved in the final step. A nine‐step sequential method is proposed to characterize trace metals in agricultural, polluted, and waste‐amended soils.
LA REFORMA DE LA EDUCACIÓN SUPERIOR ESPAÑOLA: ALGUNAS CONSIDERACIONES EN TORNO AL INFORME UNIVERSIDADES 2000 (2000)

El presente articulo se propone analizar el Informe Universidades 2000, documento elaborado por un grupo de universitarios espanoles, en el que se hace un exhaustivo diagnostico de la situacion actual de la educacion superior de ese pais. Asimismo, presenta una serie de recomendaciones para reformar la ensenanza superior, inspiradas, claramente, en la perspectiva de la llamada calidad total, fundamento teorico del modelo de lo que podemos llamar la universidad globalizada, tan en boga durante los ultimos tiempos. En estas paginas se subrayan los elementos centrales del debate actual sobre las universidades espanolas y los principales desafios que estas enfrentan. En particular, se analizan las principales recomendaciones de dicho Informe, sobre todo de aquellas que procuran hacer pasar a las universidades de un modelo colegiado a otro de gestion profesional, mas agil, eficiente y con capacidad de realizar rapidamente los cambios que lasociedad exige.
ChemInform Abstract: A DEVELOPMENT OF PICTET‐SPENGLER REACTION IN APROTIC MEDIA USING CHLOROFORMATES; A SHORT SYNTHESIS OF BORRERINE (1984)

Abstract Tryptamin (I) kondensiert mit den Aldehyden (II) zu den lminen (III), die mit Tosylchlorid (IV) zu den tricyclischen Tosylamiden (V) reagieren, mit Chlorameisensäureestern (VI) und (III) werden N‐(′arboalkoxy‐ 1,5‐earboline (VII) erhalten, die sich mit Zn/Essigsäure zu Aminen (VIII) verseifen lassen.
A wireless motion sensing system using ADXL MEMS accelerometers for sports science applications (2004)

An acceleration-based wireless motion sensing system (WMOSS) was developed for sports science applications. It is able to provide real-time information on human motions other than the conventional vision-based motion sensing systems. In this paper, we will present the working principles and system integration issues of the device. The initial calibration, signal processing and 3D self-calibration functions for the device algorithm were developed to optimize the system performance. Experiments were also conducted to analyze human motions using the WMOSS. The results from these experiments are also discussed in this paper.
Landslide Risk Analysis and Reduction for Sustainable Disaster Management:Components and Requests (2009)

Landslides continue to be a major natural disaster causing loss of life,extensive human suffering and economic losses,despite advances in understanding of mechanisms,monitoring and mitigation technologies related to landslides.However,landslides characteristics differ according to climatic,geological and
Application of computer vision in the automatic identification and classification of woven fabric weave patterns (2010)

Traditionally, fabric texture identification is based on visual inspection. Recent studies have proposed automatic recognition, which utilizes computer vision to recognize the texture of different fabrics. In the recognition process, the fabric weave patterns are identified by the warp and weft floats. However, due to the optical environments and the appearance differences of fabrics and yarns, the stability and fault-tolerance of the computer vision method are yet to be improved. By using the fabric weave patterns image identification system, this study analyzed the fabric image to find out the warp and weft by the pixel gray-level cumulative values. It then cut out the image of the warp and weft floats to obtain the texture feature values, and used the Fuzzy C-Means (FCM) algorithm to identify the warp and weft floats. The identification results can derive the black-white digital image and the digital matrix of the fabric weave patterns. Finally, weaves classification is conducted based on the successfully trained two-stage Back-Propagation Neural Network. This two-stage neural network can be used to construct the computer vision system to recognize fabric texture, and to increase the system reliability and accuracy. This study used the first-order and second-order co-occurrence matrix, and confirmed that fabric patterns can be identified and classified accurately with this method.
HANDLING AND DISPOSAL OF OILY WASTE FROM OIL SPILLS AT SEA (1995)

ABSTRACT Disposal of recovered oil and debris following an oil spill at sea can present a real challenge to the spill response team: many technical issues and options are involved. The mainly oil component should be kept separate from the mainly debris component of the waste as far as possible. This not only reduces handling problems, but also provides a better opportunity to wash or aerate the debris to allow it to be classified as nonhazardous. Nonhazardous waste landfill remains a potentially cheap option where regulations allow it. Solidification or stabilization techniques may be useful in the future to convert waste oil and debris to a suitable form for landfill. Reclamation of recovered oil is attractive in principle, particularly for large spills; but the presence of contaminants makes it difficult, in practice, for the oil to be recovered. Incineration is technically feasible and mobile/transportable systems are potentially attractive, provided permits can be obtained. A number of biological methods including land farming appear to have promise. Further development work is needed to determine possible techniques for this application.
Self‐Powered Microscale Pumps Based on Analyte‐Initiated Depolymerization Reactions (2012)

Pump it up: Insoluble polymer films that depolymerize to release soluble monomeric products when exposed to a specific analyte act as a microscale pump. Products formed as a result of depolymerization amplify the signal and create a concentration gradient that pumps fluids and insoluble particles away from the bulk polymer by a diffusiophoretic mechanism. These pumps can respond to a variety of analytes, from small molecules to enzymes. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Erlotinib is effective in pancreatic cancer with epidermal growth factor receptor mutations: a randomized, open-label, prospective trial (2015)

Gemcitabine plus erlotinib is more effective than gemcitabine alone for treating metastatic pancreatic cancer patients, especially those with EGFR mutations. ClinicalTrials.gov number, NCT01608841.
Serpentine superlattice nanowire-array lasers (1995)

We report characterization and modeling of serpentine superlattice nanowire-array lasers. These samples were grown by molecular beam epitaxy on (100) n/sup +/-GaAs vicinal substrates. In-plane ridge-waveguide lasers with ridge stripes either parallel or perpendicular to the nanowire arrays have been characterized at low temperatures. The measured net gain spectra at 1.4 K showed strong optical gain anisotropy such that the TM mode gain became greater than the TE mode gain when the optical cavity was placed along the nanowire direction. This provides strong evidence that the lateral quantum confinement in the serpentine superlattice is stronger than the vertical quantum confinement. Optical gain spectra in the serpentine superlattice are calculated with consideration of coupling between wires and homogeneous line broadening. A good fit to the measured polarization-dependent gain spectra is achieved when the lateral Al segregation and the homogeneous line broadening are chosen to be 8% and 7 meV, respectively. This small but finite Al segregation in the serpentine superlattice provides lateral quantum confinement for holes, which results in significant anisotropy in the relation between net gain and injection current density,.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Circulated-liquid calorimeter for the detection of high-power and high-energy pulsed laser signals (1977)

The design, construction, calibration, and testing of a circulated-liquid volume absorption calorimeter are described. The device is designed to operate at input irradiance/energy combinations at which surface absorption calorimeters are damaged. It has been tested with pulsed laser signals at the several-hundred-joule input level at two widely separated wavelengths and should function well at the multikilojoule level.
α-Ketocarbonyl Peptides:  A General Approach to Reactive Resin-Bound Intermediates in the Synthesis of Peptide Isosteres for Protease Inhibitor Screening on Solid Support (2001)

alpha-Ketocarbonyl peptides were generated from peptide precursors on solid support via a metal-ion-catalyzed transamination. The reaction proceeded to completion within 2 h with glyoxylate as electrophile and copper(II) ions as catalyst in an aqueous acetate buffer at pH 5.5-6.0. The variety of naturally occurring alpha-amino acid substrates gave rise to a diverse set of differentially functionalized ketones. The highly reactive terminal ketocarbonyls were prone to aldol-type dimerization and could be transferred into stable moieties by oxime formation, reduction to the alcohol, or reductive amination, respectively. The alpha-ketocarbonyl peptides were efficient in nucleophilic addition of C-nucleophiles such as phosphono-ylides and allylsilanes.
Fuzzy logic-based supervisory control of household appliances (2002)

There has been a significant change in appliance control technology in the direction of incorporating improved sensing and controls, brought about by a variety of regulatory and market forces. Cost constraints, however, continue to play a dominant role in limiting the sophistication of sensors that can be used in appliances. The challenge is to improve the control technology while adhering to the cost constraints. Techniques that extract the maximum possible information from the existing sensor suite, using a combination of conventional and heuristic methods, are required. This paper proposes a supervisory control architecture consisting of (i) rule-based parameter estimation algorithms, (ii) a method to sequentially improve parameter estimates during the course of the process via sensor integration, and (iii) a process optimization algorithm.
The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase (1992)

The gene (cefG) encoding the acetyl coenzyme A:deacetylcephalosporin C acetyltransferase of Cephalosporium acremonium (synonym Acremonium chrysogenum) C10 has been cloned. It contains two introns and encodes a protein of 444 amino acids with an M(r) of 49,269 that correlates well with the M(r) deduced by gel filtration. The cefG gene is linked to the cefEF gene (encoding the bifunctional deacetoxycephalosporin C synthase/hydroxylase), but it is expressed in an orientation opposite that of the cefEF gene. Two transcripts of 1.2 and 1.4 kb were found in C. acremonium that correspond to the cefEF and cefG genes, respectively; the degree of expression of the cefG gene was clearly lower than that of the cefEF gene in 48-h cultures. The cloned cefG complemented the deficiency of deacetylcephalosporin acetyltransferase in the nonproducer mutant C. acremonium ATCC 20371 and restored cephalosporin biosynthesis in this strain. Heterologous expression of the cefG genes took place in Penicillium chrysogenum. The deacetylcephalosporin acetyltransferase showed a much higher degree of homology with the O-acetylhomoserine acetyltransferases of Saccharomyces cerevisiae and Ascobolus immersus than with other O-acetyltransferases. The cefEF-cefG cluster of genes encodes the enzymes that carry out the three late steps of the cephalosporin biosynthetic pathway and is not linked to the pcbAB-pcbC gene cluster that encodes the first two steps of the pathway.
Dynamics and Performance of Flying Discs (2011)

The study of dynamics and performance of flying discs is motivated by how variations in their design features influence the aerodynamic characteristics and flight performance, particularly range. Reviews in the literature focus on the development of fundamental research in flying discs and on the performance of sports projectiles. Theoretical background on disc dynamics, range and sensitivity are given. This work investigates disc aerodynamics by performing wind tunnel experiments to measure aerodynamic loads on a set of generic parametric discs and a set of commercial golf discs. The parametric discs isolate various geometrical features such as thicknesses, cavities, leading edge curvatures and cambers to study the influence of these parameters on aerodynamic characteristics. The commercial golf discs consist of three different categories known as putter, mid-range and driver: these discs are used for short, medium and long flight range, respectively. To study the performance, aerodynamic data of the golf discs are used as inputs in numerical simulations to predict their flight trajectories and range. Effects of launch attitude on range are assessed to study the optimal initial launch conditions to achieve maximum range. Further, the simulation provides a direct approach to analyse range sensitivity on launch parameters.Results from the experiments show a number of significant findings on disc geometry. First, a cavity is fundamentally important for a disc to have satisfactory flying qualities: the presence of the cavity produces a significant aft shift in the aerodynamic position to minimize the pitching moment about the centre of the disc. Hence, the disc will have a minimal tendency to roll about the flight axis. Second, the thickness of a disc has a significant effect on its profile drag: increasing the thickness increases the profile drag. Third, a disc with a positive camber produces a relatively higher lift-to-drag ratio (CL/CD) compared to one with no camber. Fourth, the effect of tapering a flat leading or trailing edge of a disc leads to a reduction in its lift (within the angles of attack tested in the study) with a significant reduction in its drag. Fifth, it is shown that peak lift-to-drag ratio of a free flying disc is not necessarily a good indicator of performance because the angle of attack (and hence, lift-to-drag ratio) varies widely through a typical flight. Furthermore, a disc with a significant pitching moment will roll significantly about the flight path direction, further reducing the achievable range for a given lift or drag characteristic. Finally, a novel method to quantify disc sensitivity with respect to changes in launch conditions has been developed. The simulations show that the range sensitivity of each disc with respect to launch pitch angle varies significantly, with discs design for long range being much more sensitive (and therefore harder to throw accurately) than discs designed for short range.