gebhart/patrepeval huggingface dataset:
New advances in the treatment of Friedreich ataxia: promises and pitfalls (2011)

Friedreich ataxia (FRDA) is an autosomal recessive, neurodegenerative disease. It affects primarily the nervous system and the heart. Progressive gait and limb ataxia, dysarthria, loss of vibration and proprioceptive sense are characteristic neurological symptoms in FRDA. In approximately 96% of patients FRDA is caused by a triplet guanine-adenine-adenine expansion within the first intron of the FXN gene on chromosome 9q13. Increased numbers of guanine-adenine-adenine repeats are suggested to interfere with FXN transcription via heterochromatin-mediated silencing and result in frataxin deficiency in FRDA. Genetic and biological studies support the role of frataxin as a multifunctional protein in iron-dependent mitochondrial pathways. Multicenter, randomized-controlled Phase III trials in FRDA failed to prove disease modifying properties of candidate substances until to date. Phase II studies attributed idebenone, a synthetic short chain quinine analogue of co-enzyme Q10, some clinical benefit. Recent Phas...
Socio-Economic Factors and Their Effects on the Nutrition and Dietary Habits of the Black Aged (1982)

Abstract A review of selected literature was conducted to examine the socio-economic and nutritional status of the black elderly. Strong evidence that links adverse dietary habits to socio-economic factors is presented. The authors relate these to the group that is most affected by this - the elderly black poor. They discuss what needs to be done to develop processes and programs that promote and protect the nutritional health of the nation's black elderly.
A new look at yield of integrated circuits (1970)

Expressions are derived for integrated-circuit yield as a function of active circuit area, using as a model random distributions of indistinguishable spot defects. Previous attempts to calculate integrated-circuit yield have used a nonrandom distribution of distinguishable spot defects as their model.
A Modular Framework for Versatile Conversational Agent Building (2011)

This paper illustrates a web-based infrastructure of an architecture for conversational agents equipped with a modular knowledge base. This solution has the advantage to allow the building of specific modules that deal with particular features of a conversation (ranging from its topic to the manner of reasoning of the chatbot). This enhances the agent interaction capabilities. The approach simplifies the chatbot knowledge base design process: extending, generalizing or even restricting the chatbot knowledge base in order to suit it to manage specific dialoguing tasks as much as possible.
Processing Effects on Lycopene Content and Antioxidant Activity of Tomatoes (2001)

Consumption of tomato products has been associated with decreased risk of some cancer types, and the tomato antioxidant, lycopene, is thought to play an important role in the observed health effects. In this study, four carotenoids, trans-lycopene, phytofluene, phytoene, and zeta-carotene, were quantified in tomato products. Samples of raw tomatoes, tomato juice after hot break scalder, and final paste were obtained from two different processing plants over two years. Comparison of carotenoid levels throughout processing indicated that lycopene losses during processing of tomatoes into final paste (25-30 degrees Brix) ranged from 9 to 28%. The initial Brix level of the raw tomatoes appeared to influence the amount of lycopene loss that occurred, possibly due to the differences in processing time required to achieve the final desired Brix level of the paste. In general, no consistent changes in the other carotenoids were observed as a function of processing. The antioxidant activity of fresh tomatoes, tomato paste, and three fractions obtained from these products (i.e., aqueous, methanol, and hexane fractions) was also determined. In both a free radical quenching assay and a singlet oxygen quenching assay, significant antioxidant activity was found in both the hexane fraction (containing lycopene) and the methanol fraction, which contained the phenolic antioxidants caffeic and chlorogenic acid. The results suggest that in addition to lycopene, polyphenols in tomatoes may also be important in conferring protective antioxidative effects.
Oxidized Low Density Lipoprotein Potentiation of Fas-Induced Apoptosis Through Lectin-Like Oxidized-Low Density Lipoprotein Receptor-1 in Human Umbilical Vascular Endothelial Cells (2002)

Under normal conditions, vascular endothelial cells are resistant to Fas-mediated apoptosis, although they express detectable Fas on their cell surface. Because oxidized Low density lipoprotein (Ox-LDL) is thought to promote atherogenesis, the potential role that Ox-LDL may play in Fas-mediated apoptosis was investigated in human umbilical vascular endothelial cells (HUVECs), focusing particularly on the involvement of the lectin-like Ox-LDL receptor-1 (LOX-1). HUVECs were treated with agonistic anti-Fas antibody (CH11) and Ox-LDL and then the degree of apoptosis was determined by cell death ELISA. Ox-LDL concentration-dependently sensitized Fas-mediated apoptosis. Flow cytometry demonstrated that Ox-LDL dose-dependently up-regulated cell surface Fas expression. On the other hand, treating HUVECs with Ox-LDL did not lead to any significant change in the expression of death mediators, including Fas, Fas ligand (FasL), FADD, and FLICE as assessed by multiplex polymerase chain reaction amplification. More importantly, these effects of Ox-LDL on Fas-mediated apoptosis were significantly blocked by a neutralizing LOX-1 monoclonal antibody, which can block LOX-1-mediated cellular uptake of Ox-LDL. Ox-LDL may be an important factor involved in the regulation of Fas-induced apoptosis via Ox-LDL/LOX-1 interaction in vascular endothelial cells. The results may provide insights into the pathogenesis of accelerated atherosclerosis in patients with hyperlipidemia.
A 0.12&#x003BC;m CMOS Comparator Requiring 0.5V at 600MHz and 1.5V at 6GHz (2007)

This comparator has 2 active-load PMOS transistors that can be used to reset the output nodes to the supply level. An NMOS transistor added in the clock line controls the active loads to avoid additional reset switches and continuously biased load transistors. Two NMOSTs added in the input differential amplifier reduce the power consumption, which is 18μW at 0.5V and 600MHz, and 2.65mW at 1.5V and 6GHz
Liquid crystalline macrocycles: Novel glass‐forming nematic materials that can undergo charge transfer induced phase transitions (1997)

Macrocyclic liquid crystals incorporating two different rigid cores are reported for the first time. The synthesis of polyethercyclophanes such as that shown in the Figure is described, together with their phase behavior as investigated by differential scanning calorimetry and polarizing microscopy. The synthesis of macrocycles that combine non‐identical building blocks is describe in order to obtain materials with tailor‐made properties. magnified image
Temperature dependence of polarization characteristics in buried facet semiconductor laser amplifiers (1990)

The temperature dependence of gain and amplified spontaneous power for both TE and TM modes in semiconductor laser amplifiers are measured. Experiments are performed on three selected amplifier types, with higher TE, higher TM, and equal TE-TM gains, respectively. The gain differences are significantly reduced at higher temperature for the TE-dominant and TM-dominant amplifiers. For amplifiers with equal TE-TM gains, the TE and TM gains remain equal at high temperature. The measurements of the amplified spontaneous power show similar similar characteristics. More importantly, less polarization-sensitive gain characteristics can be obtained with some decrease in maximum gain by raising the operating temperature. The experimental results are explained by using the gain equations of the semiconductor laser amplifier.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy. (2001)

HIF-1alpha protein overexpression alone has no impact on the prognosis of ovarian cancer. The combination of HIF-1alpha protein overexpression with nonfunctional p53, however, indicates a dismal prognosis.
Autonomous mine detection system (AMDS) incorporating SFCW GPR and CWMD sensors for discrimination (2010)

Landmines have been laid in conflicts around the world and continue to maim or kill civilians and soldiers. Metal detectors (MD) have been used successfully to detect mines, but have difficulty detecting mines with little or no metal content. Ground penetrating radar (GPR) systems have successfully been used to supply detection capabilities where metal detectors fail. Handheld devices using such sensors have historically been used in battle but they can put the user at high risk under direct fire from the enemy while exposed during some operations. We describe a robotic, explosive hazard, anti-personnel/anti-tank mine detection system featuring dual-sensor GPR/MD capability for enhanced mine detection and for removing the soldier from the mine field. The MD is a broadband electromagnetic induction sensor to help discriminate between buried landmines and metal clutter. The sensor operates in the frequency domain and collects data at 21 logarithmically spaced frequencies from 300 Hz to 90 kHz. The GPR is a broadband stepped frequency continuous wave (SFCW) sensor operating from 700 MHz to 4 GHz in 10 MHz steps. The GPR employs an array of low cross section inverted V-dipoles swept over the scene. The GPR data will also support 3D synthetic aperture radar (SAR) imagery to aid in user target verification.
DialSQL: Dialogue Based Structured Query Generation (2018)

The recent advance in deep learning and semantic parsing has significantly improved the translation accuracy of natural language questions to structured queries. However, further improvement of the existing approaches turns out to be quite challenging. Rather than solely relying on algorithmic innovations, in this work, we introduce DialSQL, a dialoguebased structured query generation framework that leverages human intelligence to boost the performance of existing algorithms via user interaction. DialSQL is capable of identifying potential errors in a generated SQL query and asking users for validation via simple multi-choice questions. User feedback is then leveraged to revise the query. We design a generic simulator to bootstrap synthetic training dialogues and evaluate the performance of DialSQL on the WikiSQL dataset. Using SQLNet as a black box query generation tool, DialSQL improves its performance from 61.3% to 69.0% using only 2.4 validation questions per dialogue.
Phase-shifting errors in interferometric tests with high-numerical-aperture reference surfaces (1994)

The errors introduced by moving a spherical reference surface to generate a phase shift between the beams in a Fizeau interferometer are discussed.
Various heat-treated nickel–titanium rotary instruments evaluated in S-shaped simulated resin canals (2016)

Amongst heat-treated NiTi instruments, the CM-wire based instruments created the most favorable preparations in S-shaped resin canals.
Spontaneous Pelletization in Fine Powders (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpontaneous Pelletization in Fine PowdersH. P. Meissner, A. S. Michaels, and Robert KaiserCite this: Ind. Eng. Chem. Process Des. Dev. 1964, 3, 3, 197–201Publication Date (Print):July 1, 1964Publication History Published online1 May 2002Published inissue 1 July 1964https://pubs.acs.org/doi/10.1021/i260011a002https://doi.org/10.1021/i260011a002research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Comprehensive statistical study of 452 BRCA1 missense substitutions with classification of eight recurrent substitutions as neutral (2005)

The methods combined here can classify as neutral about 50% of missense substitutions that have been observed with two or more clearly deleterious mutations. Furthermore, odds ratios estimated for sets of substitutions grouped by A-GVGD scores are consistent with the hypothesis that most unclassified substitutions that are within the cross-species range of variation at their position in BRCA1 are also neutral. For most of these, clinical reclassification will require integrated application of other methods such as pooled family histories, segregation analysis, or validated functional assay.
Automated physical activity monitoring: Validation and comparison with physiological and self‐report measures (1993)

Physical activity can be assessed via self-report, via physiological measures such as heart rate and oxygen uptake, or via automated monitor. An electronic accelerometer-based physical activity device (Actigraph) has been reported as an improvement over other activity measurement techniques in terms of utility and accuracy. Four studies provide systematic validation and reliability testing for this device and comparisons with other techniques for assessing daily activities. In the first study, the sensitivity of the Actigraph was determined for differentiating physical activities (walking, running, stair climbing, knee bends) versus sedentary activities (reading, typing, playing video games, and performing a mental arithmetic task). Fifteen healthy adults wore the Actigraph on their wrist during activities; oxygen uptake and heart rate were simultaneously recorded. Results revealed that the Actigraph significantly differentiated between the physical activities (p < .0001) and the sedentary activities (p < .0001). Actigraph counts also correlated significantly with oxygen uptake (r = .73) and heart rate (r = .71) during physical activities (r = .46) and sedentary activities (r = .35), respectively. Test-retest reliability was very high for 12 activities (r = .98). The high level of activity differentiation and strong relationship to oxygen uptake and heart rate suggest the usefulness of this device for behavioral and biomedical studies. However, these studies also indicate that the wrist may not always be the most adequate placement for indexing rate and intensity of daily activities and that further studies are needed to determine the optimal site of monitor attachment. Advantages and disadvantages of self-report, physiological, and automated measures of activity are discussed.
[(CH<sub>3</sub>)<sub>2</sub>NH<sub>2</sub>]<sub>7</sub>Pb<sub>4</sub>X<sub>15</sub> (X = Cl<sup>–</sup> and Br<sup>–</sup>), 2D-Perovskite Related Hybrids with Dielectric Transitions and Broadband Photoluminiscent Emission (2018)

We have prepared two new lead halides with the novel general formula of DMA<sub>7</sub>Pb<sub>4</sub>X<sub>15</sub> (DMA = [(CH<sub>3</sub>)<sub>2</sub>NH<sub>2</sub>]<sup>+</sup> and X = Cl<sup>-</sup> or Br<sup>-</sup>) by using an easy route under mild conditions at room temperature. These compounds exhibit an unprecedented crystal structure, are formed by layers of distorted [PbX<sub>6</sub>] octahedra, which share corners and faces, and contain intercalated DMA cations. Very interestingly, they display dielectric transitions, which are related to a partial order-disorder process of the DMA cations between 160 and 260 K. Additionally, these new layered hybrids exhibit a broadband photoluminiscent emission, which is related to the structural distortions of the [PbX<sub>6</sub>] octahedra. These findings not only open up large possibilities for future optoelectronic applications of these materials, but they also offer a novel playground for an easy modulation of electrical and optical properties of hybrid organic-inorganic materials. We anticipate that this novel A<sub>7</sub>Pb<sub>4</sub>X<sub>15</sub> formula can be adequate to tune the family of the hybrid lead halides using other alkylammonium cations, such as methylammonium, formamidinium, or ethylammonium, to improve their photoelectronic properties.
Adaptive tone-reservation PAPR technique with optimal subcarriers allocation awareness for multi-user OFDMA systems (2011)

In this paper, an adaptive tone reservation technique with optimal subcarrier allocation awareness for multi-user OFDMA systems is investigated. In general, a variety of approaches have been proposed to cope with the PAPR problem in OFDM systems. A tone reservation (TR) is an effective technique for reducing PAPR, in which it does not need to transmit any side information and there is no distortion on the data-transmitting carriers. However, there is no rule to reserve the tone in the TR technique. In this paper, we propose to use a non-selected tone resulted from the optimal subcarrier allocation algorithm, based on the subcarrier's channel gain approach, as a reserved tone. This proposed technique could enhance the throughput while reducing PAPR of the OFDMA systems. Simulation results show that the proposed TR method with optimal subcarrier allocation in OFDMA systems achieves better PAPR reduction and throughput performance than the conventional TR without subcarrier allocation systems.
Ultraviolet‐B light treatment increases antioxidant capacity of carrot products (2012)

UV-B treatment has the potential to increase the nutritional value of carrots and offers an exciting opportunity to increase consumer accessibility to dietary choices that are rich in antioxidants.
Field analysis of a ultra broadband wide scan dual polarized array of ridge elements (2002)

A field analysis method for an infinite periodic dual polarized array of ridge elements in a square lattice is presented. Such arrays are found to possess very broadband and wide scan properties. With just nominal element spacing to avoid grating lobes, an array was designed to operate over a 5:1 frequency band and /spl plusmn/22.5/spl deg/ conical scan with an active VSWR/spl les/2.
Bionomics of Micromus posticus (Walker) (Neuroptera: Hemerobiidae) with descriptions of the immature stages (1987)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Prestack migration deconvolution (2000)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2000Prestack migration deconvolutionAuthors: Jianxing HuGerard T. SchusterJianxing HuUniversity of Utah and Gerard T. SchusterUniversity of Utahhttps://doi.org/10.1190/1.1816243 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1816243FiguresReferencesRelatedDetailsCited byLeast-squares migration of multisource data with a deblurring filterWei Dai, Xin Wang, and Gerard T. Schuster22 November 2011 | GEOPHYSICS, Vol. 76, No. 5Accelerating migration deconvolution using a nonmonotone gradient methodYanfei Wang and Changchun Yang18 August 2010 | GEOPHYSICS, Vol. 75, No. 4Simulating high resolution inversion: Decomposing the resolution functionGerrit Toxopeus, Steen Petersen, Jan Thorbecke, and Kees Wapenaar3 January 2005Poststack migration deconvolutionJianxing Hu, Gerard T. Schuster, and Paul A. Valasek7 February 2012 | GEOPHYSICS, Vol. 66, No. 3 SEG Technical Program Expanded Abstracts 2000 ISSN (print):1052-3812 ISSN (online):1949-4645 Copyright: 2000 Pages: 2484 publication data© 2000 Copyright © 2000 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 04 Jan 2005 CITATION INFORMATION Jianxing Hu and Gerard T. Schuster, (2000), "Prestack migration deconvolution," SEG Technical Program Expanded Abstracts : 984-987. https://doi.org/10.1190/1.1816243 Plain-Language Summary PDF DownloadLoading ...
Identification of Rab25 interacting molecules by a novel proteomic approach. (2008)

3521 We have recently demonstrated that RAB25 gene is overexpressed in the breast cancer and increased RAB25 gene expression correlated with a poor prognosis in breast cancer patients. In addition, enforced expression of Rab25 protein in breast cancer cells increases proliferation and decreases apoptosis. Together, these data suggest a pathological role of Rab25 proteins in the development and progression of breast tumors. Nevertheless, the relationship between Rab25 protein and breast cancer development and progression remain unknown. As the function of Rab GTPase can be controlled through recruiting specific interacting protein and activating downstream signaling molecules, it is of interest to identify associated partners mediating Rab25 function in breast cancer. We proposed to identify Rab25 interacting proteins in breast cancer cells utilizing a novel proteomic approach, retrovirus-based molecular two hybrid screen (ReMTH). ReMTH utilizes the technical advantages of two emerging technologies, the enhanced retroviral mutagen exon trap (ERM) and protein-fragment complementation assays (PCAs). ERM efficiently traps and tags endogenous genes by integration into the host genome occur upstream or inside of a host gene. This provides a facile approach to trap host proteins without the need to develop cDNA libraries providing a more readily applicable, sensitive, and unbiased screening for protein-protein interactions. In PCA, a green fluorescent protein homolog, improved fluorescent protein (IFP), was split into 2 halves N-terminal half of IFP (IFPN) and C-terminal half of IFP (IFPC). The two separated halves will not reconstitute or fluoresce spontaneously. When each half of GFP is fused to one of a pair of interacting protein partners, the subsequent protein interaction can bring the halves into proximity creating a stable complex and restoring fluorescence. In an attempt to isolate Rab25 interacting molecular in breast cancer cells, a MCF-7 Tet-off IFPN-Rab25 cell was established, infected with ReMTH-IFPC1 virus and selected with puromycin. Multiple fluorescence cells were selected through Fluorescence-Activated Cell Sorting flow cytometry core facility of the MD Anderson Cancer Center. The identity of the target genes interact with IFPN-Rab25 was determined using PCR followed by directly sequencing. Up to date, we have identified 5 putative Rab25-interacting molecules from the screening. This study was supported by Department of Defense Breast Cancer Idea Award W81XWH-06-1-0488.
Enabling high-data-rate imaging applications with Grating Light Valve technology (2004)

The Grating Light Valve diffractive MOEMS device has been successfully used in imaging applications (lithography and display) requiring image data-rates of 1-5 giga-bits per second (Gb/s). However, new applications such as maskless photolithography and high performance displays require larger pixel counts and finer control of gray-scale. This paper discusses the suitability of the GLV device for high data-rate applications. It discusses the factors governing GLV device switching speed and illustrates how these properties are optimized relative to other requirements of the imaging system.