gebhart/patrepeval huggingface dataset:
Ion implanted standards for secondary ion mass spectrometric determination of the Group IA-VIIA elements in semiconducting matrixes (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIon implanted standards for secondary ion mass spectrometric determination of the Group IA-VIIA elements in semiconducting matrixesD. P. Leta and G. H. MorrisonCite this: Anal. Chem. 1980, 52, 3, 514–519Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/ac50053a032https://doi.org/10.1021/ac50053a032research-articleACS PublicationsRequest reuse permissionsArticle Views127Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Regiocontrolled Synthesis of 1,2-Di(organo)fullerenes via Copper-Assisted 1,4-Aryl Migration from Silicon to Carbon (2011)

A concise and efficient way to generate fullerene cationic species through the oxidation of a fullerene radical or a fullerene anion with a Cu(II) salt has been developed. It was demonstrated that the cationic fullerene is useful for functionalization of fullerene, in particular, for the synthesis of noncyclic 1,2-di(organo)[60]fullerene derivatives that can be selectively prepared through intramolecular 1,4-aryl migration of an aryl group from a silicon atom to the fullerene core.
Update on Acute Lung Injury and Critical Care Medicine 2009 (2010)

This article reviews selected contributions published in 2009 regarding the epidemiology, clinical course, pathogenesis, and treatment of acute lung injury (ALI). Articles in critical care medicine that relate to multiorgan failure are also included. Research on epidemiology and genetic contributions to ALI have opened several promising areas for future studies to establish the environmental and genetic factors that influence its development and outcomes. Novel discoveries have been made on the likely role of platelets and lymphocytes in the pathogenesis and resolution of ALI. Animal and clinical studies have provided new insights regarding the mechanisms that initiate and sustain ALI and the value of both biological and clinical factors for predicting outcome in ALI. Based on preclinical studies, cell-based treatment for ALI, acute renal failure, and septic shock represents a new direction that may eventually have clinical value for therapy of critically ill patients with organ failure. The results of a multicenter randomized trial demonstrated that mortality in critically ill patients was not altered by high- compared with low-intensity renal replacement therapy. In another large randomized trial, tight glucose control worsened mortality in critically ill patients compared with conventional control.

Because the topic is broad, our comments are restricted to a subset of a number of highly meritorious publications, although we included citations for several other articles published in 2009. We primarily focused on discoveries regarding epidemiology, definitions, genetics, clinical course, pathogenesis, and new treatments, including publications from both clinical and experimental studies.
Epstein‐Barr virus specific T‐cell response in nasopharyngeal carcinoma patients (1983)

There is a substantial body of evidence suggesting an association between Epstein-Barr virus (EBV) and undifferentiated nasopharyngeal carcinoma (NPC). The present study has compared a group of NPC patients (newly diagnosed and long-term survivors) and controls for EBV-specific T-cell immunity using the regression of transformation assay. Newly diagnosed patients (17 tested) when compared with either long-term survivors (20 tested) or controls (30 tested) showed a significant impairment in virus-specific T-cell immunity (p = 0.036, p = 0.043 respectively). Furthermore, donors with IgA antibody to EBV showed a significant depression in virus-specific T-cell immunity compared with donors without IgA antibody (19 IgA-positive, 48 IgA-negative; p = 0.0025). These results may be important in explaining the postulated role of EBV in the aetiology of NPC.
Thick Film Heaters Made From Dielectric Tape Bonded Stainless Steel Substrates (1995)

Low temperature tape and thick film materials for use on stainless steel substrates in domestic appliance applications were developed. The insulating glass-ceramic coatings were applied to stainless steel bases using screen printing and tape processing. Heaters and heat regulators using PTC and other 850íC firing thick film materials were designed and built. Properties of the coated metal substrates and the heater devices are presented including initial and aged data demonstrating properties and reliability in low profile heater applications.
Role of Syk in B-cell development and antigen-receptor signaling (2000)

Antigen receptors (BCRs) on developing B lymphocytes play two opposing roles-promoting survival of cells that may later bind a foreign antigen and inhibiting survival of cells that bind too strongly to self-antigens. It is not known how these opposing outcomes are signaled by BCRs on immature B cells. Here we analyze the effect of a null mutation in the Syk tyrosine kinase on maturing B cells displaying a transgene-encoded BCR that binds hen egg lysozyme (HEL). In the absence of HEL antigen, HEL-specific BCRs are expressed normally on the surface of Syk-deficient immature B-lineage cells, but this fails to promote maturation beyond the earliest stages of B-lineage commitment. Binding of HEL antigen, nevertheless, triggers phosphorylation of CD79alpha/beta BCR subunits and modulation of receptors from the surface in Syk-deficient cells, but it cannot induce an intracellular calcium response. Continuous binding of low- or high-avidity forms of HEL, expressed as self-antigens, fails to restore the signal needed for maturation. Compared with the effects in the same system of null mutations in other BCR signaling elements, such as CD45 and Lyn kinase, these results indicate that Syk is essential for transmitting a signal that initiates the program of B-lymphocyte maturation.
Quantized Double-Layer Charging of Highly Monodisperse Metal Nanoparticles (2002)

We describe unprecedented resolution of electrochemically observed quantized double layer (QDL) charging, attained with use of reduced solution temperatures and with an annealing procedure that produces hexanethiolate monolayer protected gold clusters (C6 MPCs) with a high level of monodispersity in charging capacitance, C(CLU). The spacing DeltaV = e/C(CLU) on the electrochemical potential axis between one electron changes in the electronic charge of nanoscopic metal particles is determined by their effective capacitance C(CLU). The high monodispersity of the C6 MPCs with Au(140) cores facilitates (a) detailed rotated disk and cyclic voltammetric measurements, (b) simulation of QDL waveshapes based on assumed reversible, multivalent redox-like behavior, (c) determination of nanoparticle diffusion rates, and (d) observation of as many as 13 changes in the MPC charge state, from MPC(6-) to MPC(7+). The single electron QDL charging peaks are quite evenly spaced (DeltaV constant) at potentials near the MPC potential of zero charge, but are irregularly spaced at more positive and negative potentials. The irregular spacing is difficult to rationalize with classical double layer capacitance ideas and is proposed to arise from a correspondingly structured (e.g., not smooth) density of electronic states of the nanoparticle core, resulting from its small HOMO/LUMO gap and incipiently molecule-like behavior.
Enzymes for N-Glycan Branching and Their Genetic and Nongenetic Regulation in Cancer (2016)

N-glycan, a fundamental and versatile protein modification in mammals, plays critical roles in various physiological and pathological events including cancer progression. The formation of N-glycan branches catalyzed by specific N-acetylglucosaminyltransferases [GnT-III, GnT-IVs, GnT-V, GnT-IX (Vb)] and a fucosyltransferase, Fut8, provides functionally diverse N-glycosylated proteins. Aberrations of these branches are often found in cancer cells and are profoundly involved in cancer growth, invasion and metastasis. In this review, we focus on the GlcNAc and fucose branches of N-glycans and describe how their expression is dysregulated in cancer by genetic and nongenetic mechanisms including epigenetics and nucleotide sugar metabolisms. We also survey the roles that these N-glycans play in cancer progression and therapeutics. Finally, we discuss possible applications of our knowledge on basic glycobiology to the development of medicine and biomarkers for cancer therapy.
Synthesis of Fluorene-containing Photosensitive Polymer and Its Application to the Carbon Black-based Photoresist for LCD Color-Filter (2011)

본 연구에서는 LCD 컬러필터 레지스트용 fluorene 단위 구조를 가지는 다기능 바인더 고분자를 개발하여 카본블랙 기반 감광성 레지스트(CBR)를 제조하고 블랙 매트릭스(BM)에 적용하였다. 다기능 바인더 고분자를 얻기 위해 bisphenol fluorene epoxy acrylate를 함유한 불포화 폴리에스터(BFEA-polyester)를 합성하였으며 이는 1H NMR, GPC 및 FTIR을 이용하여 분석하였다. 합성된 BFEA-polyester 바인더 고분자를 상업용 아크릴 바인더와 비교 평가하기 위하여 각각 CBR 제조 후 BM 리소그래피 테스트를 수행하였다. 그 결과, 본 연구에서 합성된 BFEA-polyester 바인더 고분자는 적합한 광경화 반응성과 알칼리 용해성을 가질 뿐만 아니라 기존 아크릴 바인더보다 더 우수한 공정 마진, 패턴 특성 및 유리 기판에 대한 접착력을 나타내었다.
A perturbation-based balance training program for older adults: study protocol for a randomised controlled trial (2007)

This study will determine whether perturbation-based balance training can help to reverse specific age-related impairments in balance-recovery reactions. These results will help to guide the development of more effective falls prevention programs, which may ultimately lead to reduced health-care costs and enhanced mobility, independence and quality of life.
A smart sensor with hyperspectral/range fovea and panoramic peripheral view (2009)

We propose an adaptive and effective multimodal peripheral-fovea sensor design for real-time targets tracking. This design is inspired by the biological vision systems for achieving real-time target detection and recognition with a hyperspectral/range fovea and panoramic peripheral view. A realistic scene simulation approach is used to evaluate our sensor design and the related data exploitation algorithms before a real sensor is made. The goal is to reduce development time and system cost while achieving optimal results through an iterative process that incorporates simulation, sensing, processing and evaluation. Important issues such as multimodal sensory component integration, region of interest extraction, target tracking, hyperspectral image analysis and target signature identification are discussed.
Treatment With Growth Hormone and Dexamethasone in Mice Transgenic for Human Islet Amyloid Polypeptide Causes Islet Amyloidosis and β-Cell Dysfunction (1996)

Islet amyloid derived from islet amyloid polypeptide (IAPP) is a well-recognized feature of type II diabetes. However, the mechanism of islet amyloidogenesis is unknown. In vitro studies suggest that amino acid residues 20-29 in human, but not mouse, IAPP confer amyloidogenicity consistent with the absence of spontaneous islet amyloidosis in mice. Several clinical and in vitro studies suggest that increased synthetic rates of IAPP predispose to IAPP-amyloidosis. In the present study, we sought to test the hypothesis that pharmacological induction of insulin resistance in a mouse transgenic (TG) for human IAPP would induce islet amyloid and beta-cell dysfunction. TG and non-transgenic (N-TG) control mice were treated with both rat growth hormone (12 micrograms/day) and dexamethasone (0.24 mg/day) (dex/GH) or received no treatment for 4 weeks, after which animals were killed to examine islet morphology. Treatment with dex/GH caused hyperglycemia (7.3 +/- 0.4 vs. 5.2 +/- 0.1 mmol/l, TG vs. N-TG, P < 0.001) associated with a decreased plasma insulin concentration (595 +/- 51 vs. 996 +/- 100 pmol/l, TG vs. N-TG, P < 0.05) in TG versus control mice. Islet amyloid was induced in treated TG mice but not in control mice. Islet amyloid was identified in both intra- and extracellular deposits, the former being associated with evidence of beta-cell degeneration. We conclude that dex/GH treatment in mice TG for human IAPP induces IAPP-derived islet amyloid, hyperglycemia, and islet dysfunction. The present model recapitulates the islet morphology and phenotype of type II diabetes.
Expression of <i>ykdA</i> , Encoding a <i>Bacillus subtilis</i> Homologue of HtrA, Is Heat Shock Inducible and Negatively Autoregulated (2000)

ABSTRACT There are three members of the HtrA family of serine proteases, YkdA, YvtA, and YyxA, encoded in the chromosome of Bacillus subtilis . In this study, we report on the promoter structure and regulation of ykdA expression. The ykdA gene is heat inducible, exhibiting a biphasic pattern of expression during a 60-min interval after heat shock. Increased expression after heat shock occurs at the transcriptional level. The heat-shock-inducible promoter has a single mismatch with a SigA-type −10 motif, but does not exhibit similarity to a SigA −35 region. There are six octamer repeats with a consensus TTTTCACA positioned at, and upstream of, the normal position of a −35 region. While repeats V and VI appear dispensable, repeat IV is essential for normal thermoinducible expression. This promoter structure is also found in the control region of yvtA , encoding a second member of this family of proteases. Expression of ykdA is negatively autoregulated both during the growth cycle and during heat shock. Our evidence suggests that YkdA protease activity is not required for this form of regulation. Null mutants of ykdA display increased tolerance to heat and are 80-fold more resistant to 10 mM hydrogen peroxide than wild-type cells. However, ykdA expression is not induced by hydrogen peroxide. These results indicate that the regulon to which YkdA belongs is linked to the oxidative stress response in B. subtilis .
Growth and Characterization of Nocardiophages for Nocardia canicruria and Nocardia erythropolis Mating Types (1967)

Two nocardiophages were isolated from soil samples: one, called ⊘C, was specific for the Nocardia canicruria mating type; the other, called ⊘C, proliferated in N. canicruria and N. erythropolis mating types. Inactivation of phage ⊘C was rapid in NaCl solutions, with chloroform, 0–3% hydrogen peroxide and 30% (v/v) ethanol in water. Phage ⊘C behaved similarly but was less labile in NaCl solutions. Both phages were resistant to diethyl ether. Phage ⊘C could be propagated to titres of 1010 plaque-forming units/ml. on a medium containing peptone, yeast extract and calcium nitrate; the highest observed titres of phage ⊘C were also produced in this medium. A chemically defined medium for proliferation of phage ⊘C consisted of inorganic salts, valine, isoleucine, leucine, nicotinamide, glycerol. Other variables which affected the growth of these phages were the amount of phage and host inocula and the age of the host before infection. Phage ⊘C was distinct from other nocardiophages in its ability to attach quickly and efficiently to its host; 95% of the phage attached, and attachment was time and temperature dependent. Attachment of phage ⊘EC was slow and inefficient, reaching only 34%. The latent period for phage ⊘C was about 25 min., the increase period was 35 min. and the burst size about 60 particles/infective centre. The latent period of phage ⊘EC was 180 min. and the burst size about 20 particles. Both these nocardiophages possessed the typical actinophage morphology.
GaN blue light emitting diodes prepared by metalorganic chemical vapor deposition (1984)

The epitaxial layers of GaN have been grown on (0001)-oriented sapphire substrates using metalorganic chemical vapor deposition. The layers with good quality and relatively smooth surface morphology were obtained by enforcing growth in H2 after adherence of nuclei to the substrates in N2 atmosphere. Using this technique, GaN light emitting diodes with metal-insulating n-type structure were fabricated. Two kinds of blue electroluminescence were observed at room temperature with exciting voltage of 4–8 V with emission wavelength of 430 and 488 nm. The external efficiency is about 0.005%.
The Adamantyl Group in Medicinal Agents. II. Anabolic Steroid 17β-Adamantoates (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Adamantyl Group in Medicinal Agents. II. Anabolic Steroid 17β-AdamantoatesRichard T. Rapala, Russell J. Kraay, and Koert GerzonCite this: J. Med. Chem. 1965, 8, 5, 580–583Publication Date (Print):September 1, 1965Publication History Published online1 May 2002Published inissue 1 September 1965https://pubs.acs.org/doi/10.1021/jm00329a007https://doi.org/10.1021/jm00329a007research-articleACS PublicationsRequest reuse permissionsArticle Views188Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Read disturb fault detection in STT-MRAM (2014)

Spin Transfer Torque Magnetic Random Access Memory (STT-MRAM) has potential to become a universal memory technology because of its various advantageous features such as high density, non-volatility, scalability, high endurance and CMOS compatibility. However, read disturb is a major reliability issue in which a read operation can lead to a bitflip, because read and write current share the same path. This major reliability challenge is growing with technology scaling as read to write current ratio decreases. In this paper, we propose a circuit-level technique to detect read disturb by sensing the current during the read operation. Experimental results show that the proposed technique can effectively detect read disturb at the cost of negligible power and area overhead.
A simple breathing rate-sensing method exploiting a temporarily condensed water layer formed on an oxidized surface (2015)

We describe a very simple breathing rate-sensing method that detects a significant electric current change between two metal electrodes on an oxidized surface. The current change is caused by the formation of a water layer from exhaled breath. We discovered that breathing onto the oxidized surface causes instant water condensation, and it generates 20 times increased current than that measured in the inhalation period. The condensed water quickly evaporates, enabling us to detect dynamic human breathing in real time. We also investigated the breathing rate sensor by varying the relative humidity, temperature, and breathing frequency and confirmed its potential for practical applications.
Structure-activity relationships for metal-labeled blood flow tracers: comparison of keto aldehyde bis(thiosemicarbazonato)copper(II) derivatives (1990)

Radiocopper-labeled pyruvaldehyde bis(N4-methylthiosemicarbazonato)copper(II), Cu[PTSM], is under investigation as a radiopharmaceutical for evaluation of regional blood flow in the brain, heart, and kidneys because it affords relatively high levels of radioactivity in these organs upon intravenous injection, followed by prolonged tissue retention of the radiolabel. To probe and differentiate the physicochemical properties that are critical for blood-brain barrier (BBB) penetration and tissue retention in complexes of this type, 17 67Cu-labeled copper(II) bis(thiosemicarbazone) derivatives of Cu[PTSM] have been prepared and characterized, focusing on the bis(thiosemicarbazone), bis(N4-methylthiosemicarbazone), bis(N4-dimethylthiosemicarbazone), and bis(N4-ethylthiosemicarbazone) derivatives of several alkylglyoxals (R(1) = Me, Et, n-Pr, i-Pr, n-Bu, or Me(EtO)CH) and phenylglyoxal. The compounds studied varied in lipophilicity from log P = 0.75 to log P = 3.5 (where P is the octanol/water partition coefficient). In rat biodistribution studies the N4-methylthiosemicarbazone (R(1)TSM) and N4-dimethylthiosemicarbazone (R(1)TSM2) complexes always show comparable cerebral uptake at 1 min postinjection (iv) for any given R(1) group, while the thiosemicarbazone (R(1)TS) complex always penetrates the BBB less efficiently. Comparison of the various Cu[R(1)TS] derivatives shows that their brain uptake does tend to increase with increasing lipophilicity over the range 0.75 less than log P less than 2.4, although it never reaches that of the N4-alkylated derivatives. The Cu[R(1)TS] and Cu[R(1)TSM] complexes are found to exhibit prolonged cerebral retention of activity, consistent with their known susceptibility to reductive decomposition by intracellular sulfhydryl groups, while the more inert Cu[R(1)TSM2] complexes clear from the brain relatively rapidly. Tracer clearance kinetics in the heart and kidney are similar to those observed for the brain with each of the tracers examined.
Text nailing (2017)

column Share on Text nailing: an efficient human-in-the-loop text-processing method Author: Uri Kartoun IBM Research IBM ResearchView Profile Authors Info & Claims InteractionsVolume 24Issue 6November + December 2017 pp 44–49https://doi.org/10.1145/3139488Published:25 October 2017Publication History 5citation651DownloadsMetricsTotal Citations5Total Downloads651Last 12 Months148Last 6 weeks24 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access