gebhart/patrepeval huggingface dataset:
People - The Core Resource of Knowledge Management in Indian IT Scenario (2007)

Information technology (IT) has a crucial role in knowledge management (KM), as the facilitator or enabler. With the advent and increasing use of enterprise wide IT architectures, such as work flow systems and integrated packages such as ERP software (JD-Edward, SAP, Oracle, Ram Co and Microsoft Dynamics) narrow view of training will prove inadequate in preparing the future of learning human resources in organizations. While all spheres of business management today are a people technology combination in some form, knowledge management brings certain peculiarities. Knowledge is like magnificence it lies in the eyes of the beholder. Knowledge management brings three core resources-people, technologies and process. The objective of this paper is to present the case for importance of learning in the organization, and to encourage research in this area. Learning will become the key differentiator between organizations that survive and those that win.
Artificial pinning centres in YBCO thin films induced by substrate decoration with gas-phase-prepared Y<sub>2</sub>O<sub>3</sub>nanoparticles (2007)

Y2O3 nanoparticles prepared by an inert gas phase condensation process were used to introduce artificial pinning centres in YBa2Cu3O7−δ thin films. The areal density of the particles was varied between 120 and 4200 particles µm−2 without changing the mean particle diameter of approximately 9 nm. Y2O3 particles were deposited on TiO2 terminated SrTiO3 (100) single-crystal substrates with areal densities up to 1654 particles µm−2 and subsequently covered with YBa2Cu3O7−δ by off-axis pulsed laser deposition (PLD). The areal density of the room temperature deposited particles is not changed by the substrate heating during PLD although their height on the substrate decreases. An influence on Jc is demonstrated for particle densities above 1588 particles µm−2, indicating that the substrate decoration with Y2O3 nanoparticles from the gas phase affects the formation of artificial pinning centres in the YBa2Cu3O7−δ films and can be applied to further study of the effect of particle size and areal density on defect formation in YBa2Cu3O7−δ.
Asynchronous Shear Stress and Circumferential Strain Reduces Endothelial NO Synthase and Cyclooxygenase-2 but Induces Endothelin-1 Gene Expression in Endothelial Cells (2004)

Together, these data suggest that highly asynchronous mechanical force patterns (SPA=-180 degrees ) can elicit proatherogenic vasoactive responses in endothelial cells at the gene expression level, indicating a novel mechanism that induces cardiovascular pathology.
Data-driven neural network methodology to remaining life predictions for aircraft actuator components (2004)

Actuators are complex electro-hydraulic or mechanical mechanisms utilized in aircraft to drive flight control surfaces, landing gear, cargo doors, and weapon systems. Impact has developed a prognostic and health management (PHM) methodology for these critical systems that includes signal processing and neural network tracking techniques, along with automated reasoning, classification, knowledge fusion, and probabilistic failure mode progression algorithms. The processing utilizes the command/response signal and hydraulic pressure data from the actuators and provides a real-time assessment of the current/future actuator health state. This methodology was applied to F/A-18 stabilator electro-hydraulic servo valves (EHSVs) using test stand data provided by Boeing Phantom works. The automated module demonstrated excellent health state classification results. The prognosis was also successfully performed however no data was available to validate the prediction. These algorithms were developed with consideration to sensor/processing limitations for potential onboard implementation. Many of the PHM elements presented here could also be adapted for other actuator types and applications.
Tablet‐based Interactive Distraction (<scp>TBID</scp>) vs oral midazolam to minimize perioperative anxiety in pediatric patients: a noninferiority randomized trial (2014)

A TBID tool reduces perioperative anxiety, emergence delirium, and time-to-discharge and increases parental satisfaction when compared to midazolam in pediatric patients undergoing ambulatory surgery.
Fiber-Optic Surface Plasmon Resonance Sensors in the Near-Infrared Spectral Region (2006)

The sensitivity of fiber-optic surface plasmon resonance (SPR) sensors was improved by a factor of at least thirteen for aqueous solutions by modifying the tip geometry to allow interrogation of the surface plasmon (SP) band in the near-infrared (NIR) region. This was achieved by tuning the angle at the distal end of the SPR sensor to a dual taper of 71 degrees and 19 degrees . Using a low numerical aperture (NA) fiber-optic sensor, NA = 0.12, is necessary to obtain a functional SPR sensor working in the NIR region. Theoretical simulations using the Maxwell equations demonstrated that even higher enhancement is theoretically possible while maintaining a narrow spectral feature upon the excitation of the SP bands on gold surfaces. The manufacture of the SPR sensors yields good agreement between theoretical simulations and experimental observations. To investigate the properties of these fiber-optic SPR-NIR sensors, sucrose solutions ranging from 0 to 15 x 10(-3) in mole fraction were utilized. The increased sensitivity of the fiber-optic SPR sensors, when used to monitor biomarkers, would yield lower detection limits. The smaller sensing area, compared to planar or other fiber-optic SPR sensors, combined with an improvement of the sensitivity, would yield a dramatic reduction of the absolute amount detected by biosensors.
Rayleigh Scattering in Fluorine-Doped Silica Glass (2003)

The Rayleigh scatterings of fluorine-doped silica glasses as a function of fictive temperature were examined. The scattered intensity of pure silica glass increases proportionally to fictive temperature, implying that density fluctuation increases proportionally to fictive temperature. While the Rayleigh scattering caused by concentration fluctuation increases with increasing fluorine concentration, the scattering due to the density fluctuation does not seem to depend significantly on fluorine concentration.
Mediating negotiations in a virtual enterprise via mobile agents (2002)

In this paper, we propose a systematisation of the monitoring and control aspects in a virtual enterprise (VE). As an instrument, we use the mobile agent paradigm, defining the concept of a mobile agent Web (MA-Web). One of the roles of the agents in this environment is to mediate negotiations between the parties of the VE. We make some assumptions about the new behaviour and code of conduct in the MA-Web, such as the willingness to share data and knowledge.
Direct and indirect activation of nerve cells by electrical pulses applied extracellularly. (1976)

1. The mode of activation of nerve cells by extracellular stimuli was investigated while recording from a selected cell with one electrode, and applying current pulses around this cell with another electrode. The analysis was done on motoneurones and on spinal border cells from lower lumbar segments in the cat. 2. Directly evoked action potentials were defined by their appearance in an all-or-none fashion with stable latencies of less than 0-5 ms. The lowest thresholds for their generation were 0-15-0-20 muA in the spinal border cells and 0-35-0-40 muA in the motoneurones. In the main series on motoneurones a correlation has been established between different positions of the extracellular stimulating electrode in relation to the cells and the thresholds for the direct excitation of these cells. The position of the electrode were defined on the basis of an analysis of the IS and SD components of the action potentials recorded extracellularly around the cell when evoked by current pulses applied through the intracellular electrode; both the amplitudes of these IS and SD components and their timing with the IS and SD spikes, which were simultaneously recorded with the intracellular electrode, were then taken into account. The lowest thresholds (less than 2 muA) for the direct activation of cells were found nearest the initial segment of the axon. Their values increased to about 5 mu A at near-soma positions and to greater than 10 muA at near-dendrites positions about 150 mum away. 3. Transsynaptically evoked action potentials which were clearly set up by the preceding e.p.s.p.s appeared with latencies greater than 0-7 ms. When single current pulses were used, the lowest thresholds for transsynaptic spike activation were usually greater than 5-10 muA but they considerably decreased with repetitive stimuli. These thresholds were higher than the thresholds for the direct activation of cells within the region of the initial segment, of the same order of magnitude near the soma, and lower when the stimulating electrode was nearer the dendrites than the soma and generally at all larger distances from the cells. 4. All the observations on direct excitation of cells by extracellular stimuli (generation of the IS spike before the SD spike, lowest thresholds near the region of the initial segment of the axon, similar rates of increase in these thresholds with distance as for fibres) lead to the conclusion that the effects of the extracellular stimuli are exerted primarily via spread of current to the initial segment of the axon and its depolarization. 5. Late extracellular negativities presumably related to dendritic activation were observed in a few cells. These negativities were synchronous with late components of the intracellulary recorded action potentials.
Service Platform and Social Networking Service Based on Peer-to-Peer Networking (2009)

We designed and developed a virtual home platform based on peer-to-peer (P2P) based networking service. Also, we designed a P2P based social networking service method and apparatus capable of appropriately providing a social networking service under P2P environments. This paper proposed a method for easily providing a social networking service, which will be used as an application programming interface (API) on the basis of a universal P2P platform irrelevant to application characteristics.
Specific Cognitive Impairment in Sons of Early Onset Alcoholics (1989)

Cognitive and behavioral functioning in school-aged sons of early onset alcoholics, late onset alcoholics, normal social drinking fathers, and depressed fathers were compared on a battery of neuropsychological measures. Sons of early onset alcoholics performed more poorly than offspring of the normal fathers on tests measuring attention and verbal intellectual capacity, but were not significantly different from sons of late onset alcoholic fathers. Sons of normal and late onset alcoholics were not distinguishable from each other.
The Linearization of the Prebuckling State and Its Effect on the Determined Instability Loads (1969)

The effect of the linearization of the prebuckled state upon the determined buckling loads is studied first on an elastic system of two degrees of freedom and then on a shallow arch subjected to a uniform lateral load; structures that exhibit a nontrivial state of stress, an upper buckling load, a lower buckling load, and a bifurcation load. For each case the exact solution of the nonlinear formulation is discussed first. Then, using the perturbation analysis, the instability loads are determined again using the exact and the linearized prebuckled state, respectively. The paper concludes with a comparison of the obtained buckling loads and a discussion of relevant problems. It was found that the usual “adjacent equilibrium” argument presented in the literature, according to which only the displacements are perturbed, is not applicable for the determination of the bifurcation pressures of the shallow arch. A proper argument is presented and then used to determine the bifurcation and limit points.
Automatic Logic Synthesis Techniques for Digital Systems (1992)

Recent advances in microelectronics technology have led to the increasing utilisation of integrated circuit components in virtually all sectors of society. One particular component is the Application-Specific Integrated Circuit, ASIC, which is employed in such diverse products as washing machines, car engines and mainframe computers. The successful use of ASICs in products is due to the exploitation of computer-aided design tools, especially automatic synthesis tools, which reduce design time and cost. This book reviews the state-of-the-art in logic synthesis techniques, which have recently been developed for ASIC components
Effect of Phloretin on Water and Solute Movement in the Toad Bladder (1973)

It is generally believed that urea crosses the cell membrane through aqueous channels, and that its movement across the membrane is accelerated in the direction of net water flow (solvent drag effect). The present report presents evidence for a vasopressin-sensitive pathway for the movement of urea, other amides, and certain non-amides, which is independent of water flow. Phloretin, when present at 10(-4) M concentration in the medium bathing the luminal surface of the toad bladder, strongly inhibits the movement of urea, acetamide, and propionamide across the toad bladder, both in the absence and presence of vasopressin. The vasopressin-stimulated movement of formaldehyde and thiourea is also reduced. Osmotic water flow, on the other hand, is not affected; nor is the movement of ethanol and ethylene glycol, or the net transport of sodium. On the basis of these studies we would conclude that the movement of many, if not all, solutes across the cell membrane is independent of water flow, and that a vasopressin-sensitive carrier may be involved in the transport of certain solutes across the cell membrane.
Reversible Alkalinization by <i>Manduca Sexta</i> Midgut (1990)

ABSTRACT Midguts of the larva of the tobacco hornworm larva, Manduca sexta, were isolated, pinned out and double perfused on the stage of an inverted microscope. The pH gradients across the anterior, middle and posterior regions of the gut were measured with a double-barrelled pH microelectrode, simultaneously with electrical potentials and the transepithelial potential difference (TEP). The microenvironment surrounding the apical surface is more alkaline, and that surrounding the basal surface more acid, than either the perfusion medium or the intracellular pH. Under double perfusion, a stable gradient of 1.4 pH units is observed across the middle midgut. A similar gradient is found across the anterior midgut, but no significant pH difference occurs across the posterior midgut. The pH gradient across the middle midgut is reversibly and symmetrically collapsed by anoxia, implying that it is sustained by a process requiring oxidative phosphorylation. The time course of decay and reconstitution of the pH gradient matches closely the activity of electrogenic K+ pumping, as measured by the TEP. These results are consistent with a model for high pH generation which links electrogenic K+ transport into the goblet cavities with net alkalinization of the lumen of the anterior and middle midgut regions.
Levels of 5-hydroxymethyl-2′-deoxyuridine in DNA from blood as a marker of breast cancer (1996)

These results indicate that the levels of 5-hydroxymethyl-2'-deoxyuridine in DNA from peripheral nucleated blood may be potentially useful as a marker of breast cancer.
PNSOFT: a menu-driven software package for Petri-net modeling and analysis (2003)

A discussion is presented of PNSOFT, a user-friendly, menu-driven software package for Petri-net modeling and analysis of real-time systems. It aids in the design, management and analysis of Petri-net models. PNSOFT runs in an automated programming environment that provides both a graphical and a matrix interface for the creation and modification of Petri-net models in different environments. The proposed software package is written in the C programming language and is efficient with respect to both time and space. It can easily be upgraded to perform a variety of other functions. The data structures created by PNSOFT's editing facilities can be used by other application programs. Various functions and programs used for analytical operations can be directly accessed by the user, using a menu-driven interface, at different levels.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Classifying means of transportation using mobile sensor data (2010)

Mobile phone sensors have the ability to provide significant information about environmental conditions as well as about different activities of persons. This paper deals with the acceleration sensor of a commercial mobile phone that makes it possible to identify and classify the user's means of transportation. The needed pre-processing of the sensor data is described as well as the used classification algorithms, i.e. Naive Bayes classifier and Support Vector Machine (SVM). Their performance for solving the classification problem in combination with the different pre-processings is analyzed. It is shown that both classifiers are able to solve the classification task with high accuracy given a proper preprocessing. Support Vector Machines outperform Naive Bayes classifiers and achieve a classification accuracy of over 97% on an unknown test data set.
Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53 (2014)

Auranofin is a gold-containing compound classified by the World Health Organization as a clinically established rheumatoid arthritis therapeutic agent. Through drug screening for novel anticancer therapeutics, we unexpectedly identified auranofin as a potent anticancer agent against a p53-null ovarian carcinoma SKOV3 cell line. However, the molecular mechanism underlying auranofin-mediated anticancer activity in ovarian cancer cells is basically unknown. Here, we show that auranofin inhibits proliferation and survival of SKOV3 cells in a dose‑ and time‑dependent manner. Auranofin treatment activates the pro-apoptotic caspase-3, increases protein levels of apoptosis-inducing proteins Bax and Bim and reduces the expression of the anti-apoptotic mediator Bcl-2 in SKOV3 cells. Moreover, auranofin downregulates IκB kinase (IKK)-β and promotes nuclear localization and the activation of FOXO3 tumor suppressor, leading to cellular apoptosis in SKOV3 cells. In contrast, silencing FOXO3 diminishes the pro-apoptotic signaling of auranofin in SKOV3 cells. These results suggest that auranofin may induce caspase-3-mediated apoptosis in a FOXO3-dependent manner. The observed upregulation of pro-apoptotic genes and apoptosis in cancer cells without p53 in response to auranofin suggests a novel p53-independent mechanism underlying auranofin-induced apoptosis in ovarian cancer cells.
Metabolic enzymes as potential drug targets in Plasmodium falciparum. (1997)

Plasmodium falciparum causes the most severe form of malaria that is fatal in many cases. Emergence of drug resistant strains of P. falciparum requires that new drug targets be identified. This review considers in detail enzymes of the glycolytic pathway, purine salvage pathway, pyrimidine biosynthesis and proteases involved in catabolism of haemoglobin. Structural features of P. falciparum triosephosphate isomerase which could be exploited for parasite specific drug development have been highlighted. Utility of P. falciparum hypoxanthine-guanine-phosphoribosyltransferase, adenylosuccinate synthase, dihydroorotate dehydrogenase, thymidylate synthase-dihydrofolate reductase, cysteine and aspartic proteases have been elaborated in detail. The review also briefly touches upon other potential targets in P. falciparum.
The identification of specific antigens in circulating immune complexes by an enzyme‐linked immunosorbent assay: detection of bovine x‐casein IgG complexes in human sera (1981)

Circulating immune complexes have been implicated in the development of tissue injury in many chronic disease states, but in most instances the inciting antigens have not been identified. This report describes the development of a sensitive enzyme-linked immunosorbent assay which can be used to screen rapidly and simultaneously the immune complexes of numerous sera for the presence of a suspected antigen. The prototype antigen sought here was kappa-casein, a frequent participant in immune complex formation in IgA deficiency and in atopic diseases. The enzyme-antibody conjugate described here can detect as little as 0.11 ng/ml of kappa-casein; for immune complexes formed in vivo or in vitro, one can distinguish circulating complexes containing casein from complexes not containing this antigen. Using this reagent, a major antigen in the immune complexes of hypogamma-globulinemic patients treated with intravenous gamma-globulin was unexpectedly identified as kappa-casein. This method of specific immune complex analysis is suggested as a practical and effective approach to the elucidation of the antigenic constituents of immune complexes found in many diseases.
Hemodynamic Impact of Dexmedetomidine Administration in 15,656 Noncardiac Surgical Cases (2013)

Klinger, Rebecca Y.; White, William D.; Hale, Betsy; Habib, Ashraf S.; Bennett-Guerrero, Elliott Author Information
Farm organizations and farm profits in Tama County, Iowa (1925)

To learn in detail how farmers in Tama County, Iowa, have combined the elements of their businesses into going concerns, and the financial results which have attended their attempt to secure the most profitably organized farm, is the purpose of this study. It seeks not only to learn the" anatomy" or organization, but also, as far as possible, the" physiology", or operation, of the farming business as found in this area. It compares the organization of these farms in 1921 with that in 1918 and in 1913. These three years, for which data have been secured, represent pre-war conditions, war-time prosperity at its height, and post-war depression at its worst. They provide a critical test for the economic principles which have been laid down for the guidance of farmers in the organization and management of their farms.
Nucleophile Substitutionen am (<i>Z</i>)‐Perchlor‐1,3‐butadien‐1‐carbonitril mit Natriumphenolat und sekundären aliphatischen Aminen (1982)

Abstract Die Titelverbindung 1 liefert mit Natriumphenolat in Dioxan bei 70°C oder mit sek. aliphatischen Aminen in Ether bei Raumtemperatur die merocyaninartigen Trisubstitutionsprodukte 3 oder 2a – d . Die Konstitution 2 wird durch UV‐spektroskopische Untersuchungen und den Salzsäure‐Abbau zu 6 gestützt. Ringschlußreaktionen von 2 unter Amin‐Eliminierung führen mit Schwefelsäure zu den 2(1 H )‐Pyridinonen 7 und mit trockenem Chlorwasserstoff zu dem Pyridinderivat 8a .
A Biosynthetic Strategy for Re-engineering the <i>Staphylococcus aureus</i> Cell Wall with Non-native Small Molecules (2010)

Staphylococcus aureus (S. aureus) is a Gram-positive bacterial pathogen that has emerged as a major public health threat. Here we report that the cell wall of S. aureus can be covalently re-engineered to contain non-native small molecules. This process makes use of endogenous levels of the bacterial enzyme sortase A (SrtA), which ordinarily functions to incorporate proteins into the bacterial cell wall. Thus, incubation of wild-type bacteria with rationally designed SrtA substrates results in covalent incorporation of functional molecular handles (fluorescein, biotin, and azide) into cell wall peptidoglycan. These conclusions are supported by data obtained through a variety of experimental techniques (epifluorescence and electron microscopy, biochemical extraction, and mass spectrometry), and cell-wall-incorporated azide was exploited as a chemical handle to perform an azide-alkyne cycloaddition reaction on the bacterial cell surface. This report represents the first example of cell wall engineering of S. aureus or any other pathogenic Gram-positive bacteria and has the potential for widespread utility.