gebhart/patrepeval huggingface dataset:
Differential Expression of <b><i>SLC9A9</i></b> and Interacting Molecules in the Hippocampus of Rat Models for Attention Deficit/Hyperactivity Disorder (2012)

SLC9A9 [solute carrier family 9, member 9, also known as Na(+)/H(+) exchanger member 9 (NHE9)], has been implicated in human attention deficit/hyperactivity disorder (ADHD), autism, and rat studies of hyperactivity and inattentiveness. SLC9A9 is a membrane protein that regulates the luminal pH of the recycling endosome. We recently reported the interactions of SLC9A9 with two molecules: calcineurin homologous protein (CHP) and receptor for activated C-kinase 1 (RACK1). We also reported two novel SLC9A9 mutations and abnormal gene expression profiles in the brains of an inattentive type rat model of ADHD (WKY/NCrl rat). In this study, we further examined the expression and relationship of SLC9A9 and 9 additional genes (CHP, RACK1, CaM, PPP3R1, PPP1R10, PKCm, CaMKI, NR2B, PLCb1) that may directly or indirectly interact with SLC9A9 in the hippocampus of the WKY/NCrl rat and the spontaneously hypertensive rat (SHR) model of the combined type of ADHD. We found that the expression levels of these genes were significantly correlated, suggesting that they may be coregulated. Principal component analysis identified two main factors that accounted for 94% of the expression variance of the 10 genes. Significant differences were found for both factors across the 3 different rat strains. The two ADHD rat models (WKY/NCrl and SHR), although different from each other in adulthood, showed similar profiles in adolescence. Both models were significantly different from WKY/NHsd control rats at both ages. The expression abnormalities of each gene were evaluated and their roles in cell signaling processes such as calcium signaling and protein phosphorylation are discussed. Our results suggest that abnormalities in SLC9A9-mediated signaling pathways could contribute to the ADHD phenotype of two rat models (WKY/NCrl and SHR/NCrl), and that the perturbation of the SLC9A9 network is age-dependent.
Theophylline option for attenuating contrast media-induced nephrotoxicity in patients on metformin (1997)

Journal Article Theophylline option for attenuating contrast media-induced nephrotoxicity in patients on metformin Get access Don B. Nolan Don B. Nolan Staff Pharmacist Santa Rosa Health Care 519 W. Houston Street San Antonio, TX 78207 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 54, Issue 5, 1 March 1997, Pages 587–588, https://doi.org/10.1093/ajhp/54.5.587 Published: 01 March 1997
Differential etoposide sensitivity of cells deficient in the Ku and DNA- PKcs components of the DNA-dependent protein kinase (1998)

Etoposides block cell division by interfering with the action of topoisomerase II, leaving enzyme-DNA double-strand breaks. We found that certain components of the trimeric DNA-dependent protein kinase influence cell survival following etoposide damage. Interestingly, either Ku70- or Ku80-deficient cell lines, but not mutant cell lines of the DNA-PK catalytic sub-unit (DNA-PKcs), were found to be hypersensitive to the effects of etoposide VP16. Ku70- and Ku80-deficient cells can be complemented to an etoposide resistant phenotype by introducing wildtype Ku70 or Ku80 cDNAs. Mutational analysis of introduced Ku70 cDNAs into murine embryonic stem cells deleted for Ku70 (-/-) showed that mutants where heterodimerization and DNA binding functions of Ku were disrupted, also blocked the restoration of etoposide resistance. In contrast with the differential etoposide sensitivity of DNA-PK mutants, both Ku- and DNA-PKcs-deficient cell lines showed G2 ionizing radiation-induced delays, a cell cycle phase where topoisomerase II function is critical. Thus, the topoisomerase II cleaved complexes may be an example of DNA lesions requiring the Ku heterodimer, but not DNA-PK for DNA repair.
Biodiversity conservation and natural resources management in NSW: complexity, coordination and common sense (2007)

Most environmental lawyers, like ecologists, wish to see broad scale landscape change, better management of land and improved protection of remnant vegetation and threatened species. Incorporating scientific knowledge into effective strategic planning is one step. Implementing strategic planning is another, necessitating the flow of priorities into statutory planning and regulation. The translation of broad landscape scale conservation objectives on to the ground requires not only improved understanding but also active use of the legal system. The law relating to the regulation of land use and vegetation clearing, threatened species conservation and catchment management is complex, inter-dependent and dynamic. While planning was once the exclusive domain of local government, now state government natural resource agencies and catchment management bodies routinely use it to determine priorities for both regulation and investment. In this paper we explore the potential of the current system for conservation. We consider the potential of the land use planning system and argue that its role has been constrained by its history. While there is significant reform in coastal and growth areas, rural areas continue to be neglected by this system. This gap would appear to be being filled in NSW by catchment management, which has a key planning role and is grappling with the management of existing uses; and native vegetation legislation which focuses on new development.
Experimental realization of an O-band compact polarization splitter and rotator (2017)

We experimentally realize a compact wideband polarization splitter and rotator (PSR) with CMOS compatibility. The fabricated PSR is then tested by utilizing a fabrication-tolerant TE-pass on-chip polarizer we propose to practically solve the issue of accurately aligning the polarizations in fiber and modes on chip. Both of these polarization handling devices take the advantage of bend structure that confines TE mode better than TM mode. The fabricated PSR has a high TM-TE and TE-TE mode conversion efficiency of -0.4 dB and -0.2 dB at 1310 nm, while the extinction ratio is better than 18 dB and the broad bandwidth exceeds 100 nm.
PWMDS: A system supporting provenance-based matching and discovery of workflows in proteomics data analysis (2012)

Provenance plays a fundamental role in e-science to keep track of the data processing execution, evaluate the data quality, reproduce the analysis results, and especially share and re-use workflows. How to take full advantage of provenance to help scientists discover, match and select scientific workflows is a challenging work. Although some studies have been done to model, store, and query scientific workflows, little is done to build practical systems to support workflow matching and discovery. In this paper, we devise and implement a Provenance-Based Workflow Matching and Discovery System (PWMDS) for task-based pipelines in a proteomics data analysis platform called CoPExplorer to address the above challenge. With the proposed novel provenance model and workflow matching & discovery algorithms, PWMDS can provide scientists a ranked list of suitable service candidates for their specified workflows, and initial experiments demonstrate its effectiveness.
Studies on the Decomposition of Alkyl Hydroperoxides by different catalysts (1988)

Abstract The catalytic decomposition of cumene, 1‐methylcyclohexyl and cyclohexyl hydroperoxides was studied in cyclohexane, cis‐ and trans‐1,4‐dimethylcyclohexane and cis‐pinane as the solvents. The stearates and the acetylacetonates of manganese, cobalt and chromium, the acetylacetonates of molybdenum and vanadium, n‐butyl orthoborate and n‐butyl metaborate were used as the catalysts. The chromium‐, vanadium‐, molybdenum‐ and boron‐containing catalysts brought about some Hock‐type decomposition of cumene hydroperoxide and thus proved to be acidic. Of these more of less acidic catalysts only molybdenyl acetylacetonate effected a partially stereospecific hydroxylation of the tertiary CH‐bonds in cis‐ and trans‐1,4‐dimethylcyclohexane. The well‐known selectivity of chromium catalysts for the ketone formation during the decomposition of secondary hydroperoxides is caused by the catalytic oxidatio of secondary alcohols by hydroperoxides in the presence of chromium compounds. In the presence of all the catalysts used the free‐radical pathways of the hydroperoxide decomposition predominated, and the attack of the intermediate radicals on the starting hydroperoxide was more important than the attack on the solvent molecules.
Evaluation of Inducible Nitric Oxide Synthase in Glaucomatous Optic Neuropathy and Pressure-Induced Optic Nerve Damage (2005)

As demonstrated by several independent methods, glaucomatous optic neuropathy was not associated with a significant change in the expression of NOS-2 in the retina, ONH, or optic nerve.
Primary health care in Somalian refugee camps. (1982)

The convergence of thousands in Somalia's refugee camps has created an emergency in health care provision. To tackle this problem, the Ministry of Health, in conjunction with UNICEF, recruited a small group of Somali professionals to draw up a plan for the training of community health workers to serve in the camps. A 2nd objective was to make an assessment of the nutritional status of the refugees, and provision of maternal and child health care. At the end of a 2 week workshop a plan was drawn up which emphasized the teaching of preventive medicine, particularly in the control of communicable diseases. It was decided that students in the postbasic training program in administration and teaching in the health service would serve as teachers. Teaching was kept basic and simple, mostly concentrating on topics related to hygiene and food preparation, for example. During program implementation inspection visits were carried out at intervals by a health educator and tutor from the nursing school. At the same time further briefing was given to as many concerned people in the camps as possible. Preliminary feedback suggested that the program was proceeding successfully. After 3 months an evaluation was carried out by teachers in the program. The evaluation showed a great deal to have been accomplished in spite of the disinterest of some parts of the population. The success was attributed to the involvement of Somalis in the camp communities. As of September 1981, the pace of the programs has increased, with the inclusion of health services from expatriate sources within Ministry of Health guidelines.
ISOLATION AND CHARACTERIZATION OF TWO ß1-GLYCOPROTEINS OF HUMAN SERUM (1960)

Two immunoelectrophoretically defined, heretofore unidentified beta(1)-globulins of human serum, provisionally designated beta(1C)- and beta(1A)-globulin, were isolated by means of preparative electrophoresis and chromatography on anion exchange cellulose. The sedimentation coefficient S(0) (20, w) of beta(1C)-globulin was shown to be 9.5 S, and that of beta(1A)-globulin, 6.9 S. Both proteins were found to contain similar amounts of carbohydrate, to be devoid of lipids, and to possess the solubility characteristics of euglobulins. In the Ouchterlony double diffusion test they gave the reaction of partial identity, which revealed beta(1A)-globulin to be anti-genically deficient as compared to beta(1C)-globulin. beta(1A)-globulin could not be detected in fresh sera and beta(1C)-globulin was absent from aged sera. Highly purified beta(1C)-globulin stored at 1 degrees C. was converted to beta(1A)-globulin within 4 to 6 weeks, and at 37 degrees C. was converted within 6 days. The likelihood of a dimer-monomer relationship between these two proteins was discussed.
<title>Linearity and effective optical pathlength of liquid waveguide capillary cells</title> (1999)

The validity of using Beer's Law to describe liquid waveguide capillary cells (LWCC) as absorption cells with increased optical pathlength was investigated. Experimental and theoretical results for two types of LWCC are presented. 'Type I' LWCCs are constructed with solid TEFLON AF tubing. 'Type II' LWCCs consist of quartz tubing with an outer coating of TEFLON AF. UV/Vis absorbance spectra versus chromophore concentration were found to be linear for both LWCC types within the wavelength range and absorbance accuracy of the spectrophotometer used. The ratio between 'effective' and 'physical' pathlength, EPLR was determined experimentally for both LWCC types. Type I cells had an effective optical pathlength that was statistically indistinguishable from the physical pathlength on a 95 percent probability basis. Type II cells had an effective optical pathlength that was slightly shorter than the physical pathlength, dependent on the cell's inner diameter and wall thickness. A theoretical model explaining Type I LWCC result is presented. Our results indicate that Beer- Lambert's Law can be applied to both types of LWCCs for UV/Vis absorption spectroscopy.
A administración única e o dereito laboral (1992)

Electron tomography (ET) has been used for quantitative measurement of shape and size of objects in three dimensions (3D) for many years. However, systematic investigation of repeatability and reproducibility of ET has not been evaluated in detail. To assess the reproducibility and repeatability of a protocol for measuring size and three-dimensional (3D) shape parameters for nanoparticles (NPs) by ET, an inter-laboratory comparison (ILC) has been performed. The ILC included six laboratories and six instruments models from three instrument manufacturers following a standard measurement protocol. A technical specification describing the normative steps of the protocol is published by the International Standards Organization (ISO). Gold NPs with 30 nm nominal diameter contained within a rod-shaped carbon support were measured. The use of a rod-shaped sample support eliminated the missing wedge effect in the experimental tilt series of projected images for improved quantification. A total of 443 NPs were initially measured by NRC-NANO and then 115 out of the 443 NPs were measured by five other labs to compare measurands such as the Volume (V), maximum Feret diameter (F<sub>max</sub>), minimum Feret diameter (F<sub>min</sub>), volume-equivalent diameter (D<sub>eq</sub>) and aspect ratio (F<sub>rat</sub>) of the NPs. The results of the five labs were compared with the results obtained at NRC-NANO. The maximum disagreement in measurements of F<sub>min</sub> and F<sub>max</sub> obtained by the participating labs did not exceed 7 %. The measured D<sub>eq</sub> was between 27.5 nm and 30.3 nm in agreement with the NP manufacturer's specification (28 nm-32 nm). In addition to the above, the influence of the missing wedge effect and beam-induced NP movement was quantified based on the differences of the results between labs.
Practical Anonymous Password Authentication and TLS with Anonymous Client Authentication (2016)

Anonymous authentication allows one to authenticate herself without revealing her identity, and becomes an important technique for constructing privacy-preserving Internet connections. Anonymous password authentication is highly desirable as it enables a client to authenticate herself by a human-memorable password while preserving her privacy. In this paper, we introduce a novel approach for designing anonymous password-authenticated key exchange (APAKE) protocols using algebraic message authentication codes (MACs), where an algebraic MAC wrapped by a password is used by a client for anonymous authentication, and a server issues algebraic MACs to clients and acts as the verifier of login protocols. Our APAKE construction is secure provided that the algebraic MAC is strongly existentially unforgeable under random message and chosen verification queries attack (suf-rmva), weak pseudorandom and tag-randomization simulatable, and has simulation-sound extractable non-interactive zero-knowledge proofs (SE-NIZKs). To design practical APAKE protocols, we instantiate an algebraic MAC based on the q-SDH assumption which satisfies all the required properties, and construct credential presentation algorithms for the MAC which have optimal efficiency for a randomize-then-prove paradigm. Based on the algebraic MAC, we instantiate a highly practical APAKE protocol and denote it by APAKE, which is much more efficient than the mechanisms specified by ISO/IEC 20009-4. An efficient revocation mechanism for APAKE is also proposed.
Prognostic Factors for Outcome in Patients With Aneurysmal Subarachnoid Hemorrhage (2007)

Although most prognostic factors for outcome after SAH are present on admission and are not modifiable, a substantial contribution to outcome is made by factors developing after admission and which may be more easily influenced by treatment.
Dynamic high pressure–induced gelation in milk protein model systems (2010)

The structure-functional properties of milk proteins are relevant in food formulation. Recently, there has been growing interest in dynamic high-pressure homogenization effects on the rheological-structural properties of food macromolecules and proteins. The aim of this work was to evaluate the effects of different homogenization pressures on rheological properties of milk protein model systems. For this purpose, sodium caseinate (SC) and whey protein concentrate (WPC) were dispersed at different concentrations (1, 2, and 4%), pasteurized, and then homogenized at 0, 18MPa (conventional pressure, CP), 100MPa (high pressure, HP), and 150MPa (HP+). Differences in viscosity were observed between WPC and casein dispersions according to concentration, heat treatment, and homogenization pressure. Mechanical spectra described the characteristic behavior of solutions except for the WPC 4% pasteurized sample, in which a network formed but was broken after homogenization. Dispersions with different ratios of WPC and SC were also made. In these systems, pasteurization alone did not determine network formation, whereas homogenization alone promoted cold gelation. A total concentration of at least 4% was required for homogenization-induced gelation in pasteurized and unpasteurized samples. Gels with higher elastic modulus (G') were obtained in more concentrated samples, and a bell-shaped behavior with the maximum value at HP was observed. The HP treatment produced stronger gels than the CP treatment. Similar G' values were obtained when different concentrations, pasteurization conditions, and homogenization pressures were combined. Therefore, by setting appropriate process conditions, systems or gels with tailored characteristics may be obtained from dispersions of milk proteins.
Graphene Imaging Using REELS Spectra by Auger Electron Spectroscopy (2018)

Detection of thin film such as graphene is important technology for application to industrial products. Auger electron spectroscopy (AES) is well known for analyzing the surface of solid samples with thickness less than 6 nm. AES has been developed as a useful technique for chemical state analysis. However, the chemical state analysis of AES can be performed on limited elements. In this report, we examine the use of Reflection Electron Energy Loss Spectroscopy (REELS) obtained by AES instrument for chemical state analysis of carbon.
Matched Filter Based Algorithm for Blind Recognition of OFDM Systems (2008)

In the cognitive radio context, sensing process is a crucial task. The cognitive devise has to be able to detect and to identify several radio systems. As more standards are now based on OFDM modulation the paper aims with the parameters estimation of such a modulation. All actual OFDM-based standards differ from their subcarrier spacing therefore it will be ingenious to focus on this parameter to identify these systems in a non data aided context. We propose a new efficient algorithm based on the matched filter principle. The behavior of the proposed approach will be studied in the context of practical impairments like frequency and/or time offsets and a multi-paths fading channel. Finally, the performance of the proposed algorithm will be evaluated in contrast with the state of art methods by means of computer simulations.
Comparative analysis between impulsive detection methods applied on partial discharge acoustic signals (2014)

Partial discharges (PD) plays an important role on power transmission lines and equipment failures therefore previously detect this high-voltage phenomena can prevent severe damages and avoid further outlay. Spark gaps discharges are among the most common PD in power transformers and other efficiency energy equipments. And in order to detect this effect optical and acoustic sensors are normally employed into monitoring systems. However optical sensors are expensive for transmission power lines and detecting acoustical signals from PD can be difficult since they are normally followed by other background sounds. In order to improve detection sound systems in this work we compare two methods that are regularly used on impulsive signal processing, the Variance Method (VM) and the Conditional Median Filter (CMF), to detect PD acoustic signals. From the presented results it is observed that the CMF is more appropriated for detecting impulsive PD although the VM detected less false positive discharge and can still be further optimized.
Rating Computer-Generated Questions with Mechanical Turk (2018)

We use Amazon Mechanical Turk to rate computer-generated reading comprehension questions about Wikipedia articles. Such application-specific ratings can be used to train statistical rankers to improve systems’ final output, or to evaluate technologies that generate natural language. We discuss the question rating scheme we developed, assess the quality of the ratings that we gathered through Amazon Mechanical Turk, and show evidence that these ratings can be used to improve question generation.
Age, Sex and Anxiety Affect Locomotor Activity in Rats (2012)

The main objective of study was to investigate the effects of age, sex and anxiety differences on locomotor activity in rats. Locomotor activity was assessed in open field (OF). Repeated anxiety tests were performed in elevated plus maze (EPM). All behavioral tests were recorded online and analyzed offline with analytical software. In conclusion, age, sex and anxiety affect locomotor activity in different aspects.
Fire! (1875)

Journal Article Fire! Get access A. G. A. A. G. A. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s5-IV, Issue 81, 17 July 1875, Pages 58–59, https://doi.org/10.1093/nq/s5-IV.81.58g Published: 17 July 1875