gebhart/patrepeval huggingface dataset:
Intraplaque Hemorrhage (2006)

Intraplaque hemorrhage is a common feature of atherosclerotic plaques and is considered one of the identifying features of complex lesions preceding acute ischemic events. The cause of intraplaque hemorrhage is most often secondary to rupture of neovessels, which have invaded the plaque. However, inflammation and metabolic factors such as diabetes may also precipitate hemorrhage from mature microvessels by damaging the endothelium. The mechanism by which hemorrhage destabilizes the plaque is in large part secondary to the action of hemoglobin released from red blood cells at the site of the hemorrhage. Hemoglobin is a potent pro-inflammatory agent by virtue of its ability to promote formation of ROS. The major defense mechanism against the toxic effects of extracorpuscular hemoglobin is the protein haptoglobin, which tightly binds to hemoglobin and prevents it from catalyzing oxidative reactions. There exists a common allelic polymorphism in the haptoglobin gene, which has recently been strongly associated with the risk of cardiovascular disease in multiple independent cohorts. The protein products of the two different haptoglobin alleles differ in their ability to serve as an antioxidant against hemoglobin and also to activate the CD163 receptor. This review presents a unifying hypothesis whereby the haptoglobin genotype is proposed to modulate the response to intraplaque hemorrhage and thereby play a fundamental role in determining the morphological and metabolic features of complex plaques preceding acute ischemic events.
Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. (1995)

Amyloid beta-protein (A beta), the principal constituent of senile plaques seen in Alzheimer's disease (AD), is derived by proteolysis from the beta-amyloid precursor protein (beta PP). The mechanism of A beta production in neurons, which are hypothesized to be a rich source of A beta in brain, remains to be defined. In this study, we describe a detailed localization of cell surface beta PP and its subsequent trafficking in primary cultured neurons. Full-length cell surface beta PP was present primarily on perikarya and axons, the latter with a characteristic discontinuous pattern. At growth cones, cell surface beta PP was inconsistently detected. By visualizing the distribution of beta PP monoclonal antibodies added to intact cultures, beta PP was shown to be internalized from distal axons or terminals and retrogradely transported back to perikarya in organelles which colocalized with fluid-phase endocytic markers. Retrograde transport of beta PP was shown in both hippocampal and peripheral sympathetic neurons, the latter using a compartment culture system that isolated cell bodies from distal axons and terminals. In addition, we demonstrated that beta PP from distal axons was transcytotically transported to the surface of perikarya from distal axons in sympathetic neurons. Indirect evidence of this transcytotic pathway was obtained in hippocampal neurons using antisense oligonucleotide to the kinesin heavy chain to inhibit anterograde beta PP transport. Taken together, these results demonstrate novel aspects of beta PP trafficking in neurons, including retrograde axonal transport and transcytosis. Moreover, the axonal predominance of cell surface beta PP is unexpected in view of the recent report of polarized sorting of beta PP to the basolateral domain of MDCK cells.
Discovery of Imidacloprid and Further Developments from Strategic Molecular Designs (2010)

The invention of imidacloprid, the most important neonicotinoid insecticide, was initiated by replacement of the framework of nithiazine with an imidazolidine ring. Through the finding of 1-(6-chloro-3-pyridylmethyl)-2-nitromethyleneimidazolidine, imidacloprid was invented. At the same time cyanoiminothiazolidinyl neonicotinoid thiacloprid was discovered. These products possess pronounced systemic properties and improved photostability in addition to supreme insecticidal ability. Crystal structure analysis led to the drug-receptor interaction model consisting of the guanidine (amidine) part conjugated to a powerful electron-withdrawing group bearing an H-bond accepting tip such as NO(2) or CN, and the chloronicotinyl group enhances the binding to the receptor. The QSAR study not only supports the key pharmacophore but also clarifies the crucial involvement of the phamacokinetic factors in the insecticidal activity. A concept for strategic and rational design led to the discovery of alkylene-tethered bis-imidacloprid derivatives with unexpected systemic insecticidal property and the unique binding mechanism revealing the second cavity in the neonicotinoid receptor.
Effects of short‐term oral dosing of polychlorotrifluoroethylene (polyCTFE) on the rhesus monkey (1991)

Polychlorotrifluoroethylene (polyCTFE--primarily oligomers with 3-4 monomer units), a non-flammable hydraulic fluid for aircraft, was given daily for 15 days by oral gavage to four Rhesus monkeys at a concentration of 0.725 g kg-1. The administered dose was at a level that had caused toxicity in rats. Steady-state blood and liver concentrations reached were the same in both species. In monkeys, polyCTFE did not cause the electrolyte, serum protein, liver enzyme and anemic disturbances previously seen in rats. Liver sections taken at 15 days, analyzed for palmitoyl Co-A beta-oxidation rates or by electron microscopy, showed no significant indication of peroxisomal proliferation. An increased blood urea nitrogen (BUN) at 15 days was the only clinical pathological abnormality seen in both monkeys and rats. Previously unobserved effects were increased triglycerides and glycogen depletion.
Identification, Typing, and Insecticidal Activity of <i>Xenorhabdus</i> Isolates from Entomopathogenic Nematodes in United Kingdom Soil and Characterization of the <i>xpt</i> Toxin Loci (2006)

Xenorhabdus strains from entomopathogenic nematodes isolated from United Kingdom soils by using the insect bait entrapment method were characterized by partial sequencing of the 16S rRNA gene, four housekeeping genes (asd, ompR, recA, and serC) and the flagellin gene (fliC). Most strains (191/197) were found to have genes with greatest similarity to those of Xenorhabdus bovienii, and the remaining six strains had genes most similar to those of Xenorhabdus nematophila. Generally, 16S rRNA sequences and the sequence types based on housekeeping genes were in agreement, with a few notable exceptions. Statistical analysis implied that recombination had occurred at the serC locus and that moderate amounts of interallele recombination had also taken place. Surprisingly, the fliC locus contained a highly variable central region, even though insects lack an adaptive immune response, which is thought to drive flagellar variation in pathogens of higher organisms. All the X. nematophila strains exhibited a consistent pattern of insecticidal activity, and all contained the insecticidal toxin genes xptA1A2B1C1, which were present on a pathogenicity island (PAI). The PAIs were similar among the X. nematophila strains, except for partial deletions of a peptide synthetase gene and the presence of insertion sequences. Comparison of the PAI locus with that of X. bovienii suggested that the PAI integrated into the genome first and then acquired the xpt genes. The independent mobility of xpt genes was further supported by the presence of xpt genes in X. bovienii strain I73 on a type 2 transposon structure and by the variable patterns of insecticidal activity in X. bovienii isolates, even among closely related strains.
Band Inversion and the Electrical Properties of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Pb</mml:mi></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Sn</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn><mml:mo>−</mml:mo><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mi mathvariant="normal">Te</mml:mi></mml:math> (1968)

The electrical resistivity and Hall coefficient of ${\mathrm{Pb}}_{x}{\mathrm{Sn}}_{1\ensuremath{-}x}\mathrm{Te}$ alloys were determined as a function of temperature from 4 to 300\ifmmode^\circ\else\textdegree\fi{}K. The measurements were intended as a test of Dimmock, Melngailis, and Strauss's band-inversion model in the immediate region of band crossing. The resistivity is characterized by a predominantly linear dependence upon $T$, and by the distinct breaks which occur in this dependence. The linearity is attributed to degenerate lattice scattering. The temperatures at which the breaks occur depend upon alloy composition, and are relatively independent of carrier concentration and carrier mobility. These break temperatures are in excellent agreement with band-crossing temperatures predicted on the basis of the band-inversion model. This fact, along with several other features of the results, strongly supports the band-inversion model.
Nature-Inspired Optimization Techniques in Communication Antenna Designs (2012)

This paper summarizes the primary features inherent in current optimization methods typically applied to antenna designs and demonstrates their effectiveness by applying particle swarm optimization (PSO), a nature-inspired global optimization technique, to novel antenna design solutions in wireless communications. The concept of the PSO technique is briefly introduced and an outline of the important parameters that are utilized is summarized. Next, an implementation strategy combining PSO with numerical algorithms for electromagnetic solutions, namely the finite element method (FEM) and the method of moments (MoM), is discussed. In both realizations (PSO-FEM and PSO-MoM), the PSO technique drives the design variables, such as the antenna dimensions, geometrical features, etc., and the full-wave electromagnetic analysis engines evaluate the fitness function for the optimizer. Optimized antenna designs including a multiband handset antenna and an E-shaped patch antenna for circularly polarized (CP) applications are presented. Measurement results of prototype optimized designs are shown to demonstrate the functionality and effectiveness of the methodologies presented in this paper.
A 0.5-V sub-mW wireless magnetic tracking transponder for radiation therapy (2011)

As the position of the tumor in a patient moves during radiation therapy, real-time knowledge of the position of the tumor is necessary in order to allow the maximum amount of radiation to be focused on the tumor and the minimum damage on the surrounding healthy tissues. A 0.5-V sub-mW wireless active transponder for a magnetic tracking system is designed in 130-nm CMOS technology to track the position of the tumor. The transponder consumes only 912 µW and an error of less than 5 mm is achieved with the tracking system.
The effect of cryopreservation on canine menisci: A biochemical, morphologic, and biomechanical evaluation (1988)

This study evaluated the effect of cryopreservation on the structural organization, biosynthetic activity, and material properties of canine menisci. The menisci were cryopreserved by incubating them in a 4% solution of dimethyl sulfoxide (DMSO) in physiologic media and freezing them to -100 degrees C using a controlled rate freezing system. The menisci were then stored for varying periods of time from zero to 12 weeks in liquid nitrogen (-196 degrees C). Following rapid thawing, changes in the histological appearance and biosynthetic activity of the menisci were evaluated as functions of storage time. In addition, the effects of the cryopreservation process on the tensile strength and modulus of the meniscal tissue were assessed. Although cryopreservation and short-term storage did not appear to affect the morphological appearance or biomechanical character of the menisci, biosynthetic activity, as determined by Na2S35SO4 incorporation, was diminished to less than 50% of normal control values immediately following cryopreservation and thawing. Autoradiographic examination of these tissues revealed that only approximately 10% of the meniscal cells were metabolically active, however, indicating that a marked increase in the metabolic activity of individual cells occurs following the freeze-thaw cycle. Total metabolic activity continued to decline with storage time.
[Effect of escharectomy during burn shock stage on bacterial and endotoxic translocation from the gut]. (1996)

120 SPF rats (Wistar) were randomly divided into 3 groups (1) simple skin grafting group (Group A). (2) Escharectomy during burn shock group (Group B). (3) Routine escharectomy group (Group C) Full-thickness burn of 30% TBSA was produced in Group B and Group C. One hour after scald intravenous fluid replacement was instituted. First stage escharectomy has been performed 24 hours after burn and 5 days postburn. The results demonstrated that the contents of both plasma LPS and TNF in Group B were significantly lower as compared with these in Group C. Our data indicated escharectomy during burn shock would effectively eliminate the effects of the endotoxemia. Endotoxin play an important role in the bacterial and endotoxic translocation.
Radiative recombination in type-II GaSb/GaAs quantum dots (1995)

Strained GaSb quantum dots having a staggered band lineup (type II) are formed in a GaAs matrix using molecular beam epitaxy. The dots are growing in a self-organized way on a GaAs(100) surface upon deposition of 1.2 nm GaSb followed by a GaAs cap layer. Plan-view transmission electron microscopy studies reveal well developed rectangular-shaped GaSb islands with a lateral extension of ∼20 nm. Intense photoluminescence (PL) is observed at an energy lower than the GaSb wetting layer luminescence. This line is attributed to radiative recombination of 0D holes located in the GaSb dots and electrons located in the surrounding regions. The GaSb quantum dot PL dominates the spectrum up to high excitation densities and up to room temperature.
In vitro activities of PS-15, a new dihydrofolate reductase inhibitor, and its cyclic metabolite against Mycobacterium avium complex (1995)

PS-15, a new dihydrofolate reductase inhibitor, and its cyclic metabolite were evaluated for in vitro activity against 31 clinical Mycobacterium avium complex isolates. Broth dilution MICs of PS-15 ranged from 16 to 64 micrograms/ml. The cyclic metabolite was three to five times more active than the parent compound. Further evaluation of these compounds in an M. avium-infected murine test system will be of interest.
NAD‐dependent lactate dehydrogenase catalyses the first step in respiratory utilization of lactate by <i>Lactococcus lactis</i> (2013)

Lactococcus lactis can undergo respiration when hemin is added to an aerobic culture. The most distinctive feature of lactococcal respiration is that lactate could be consumed in the stationary phase concomitantly with the rapid accumulation of diacetyl and acetoin. However, the enzyme responsible for lactate utilization in this process has not yet been identified. As genes for fermentative NAD-dependent l-lactate dehydrogenase (l-nLDH) and potential electron transport chain (ETC)-related NAD-independent l-LDH (l-iLDH) exist in L. lactis, the activities of these enzymes were measured in this study using crude cell extracts prepared from respiratory and fermentation cultures. Further studies were conducted with purified preparations of recombinant LDH homologous proteins. The results showed that l-iLDH activity was hardly detected in both crude cell extracts and purified l-iLDH homologous protein while l-nLDH activity was very significant. This suggested that l-iLDHs were inactive in lactate utilization. The results of kinetic analyses and the effects of activator, inhibitor, substrate and product concentrations on the reaction equilibrium showed that l-nLDH was much more prone to catalyze the pyruvate reduction reaction but could reverse its role provided that the concentrations of NADH and pyruvate were extremely low while NAD and lactate were abundant. Metabolite analysis in respiratory culture revealed that the cellular status in the stationary phase was beneficial for l-nLDH to catalyze lactate oxidation. The factors accounting for the respiration- and stationary phase-dependent lactate utilization in L. lactis are discussed here.
Autonomous SLAM technique with stereo vision (2008)

This paper proposes some algorithms integrating grid and topology map and its performance is faster and more stable. The proposed scheme uses an occupancy grid map in representing the environment and then formulate topological information in path finding by A* algorithm. The localization process and the dynamic obstacle avoidance can be accomplished by topological information on grid based map. On simulator mapping process is shown and the shortest path is decided on grid based map. Then topological information such as direction, distance is calculated on simulator program then transmitted to robot hardware devices. Only one stereo camera and electronic compass are implemented on our mobile robot and two DC geared motor wheels are individually controlled by PD control method. Stereo matching was accomplished by image processing from two parallel positioned cameras and new algorithms such as fast object labeling, measuring depth by image overlapping and local information of optical flow. Simulations and experimental results show the performance and efficiency of the proposed scheme.
Effects of glycyrrhizin on UVB-irradiated melanoma cells. (2005)

It is known that liquorice root is rich in compounds which exert several pharmacological actions. In the present study, we evaluated the effect of glycyrrhizin (the main constituent of liquorice root) and of its metabolite aglycone, 18beta-glycyrrhetinic acid, on UVB-irradiated human melanoma cells: SKMEL-2 from metastatic tissue and SKMEL-28 from primary malignant melanoma. Tests performed (Trypan blue exclusion test, MTT and Western blot) showed that glycyrrhizin is not toxic for both types of cells. In SKMEL-28 cells, Bcl-2 expression was low after UVB irradiation, but it was increased when treated with glycyrrhizin. On the contrary, in the SKMEL-2 cell culture, Bcl-2 expression was not modified by the substances under study. The results show that glycyrrhizin treatment might offer protection from the damage induced in humans by UVB radiation, while it seems to be ineffective on metastatic cells. Further studies must be performed to understand the mechanism of the protective effect.
A NEW DRESSING FOR SKIN GRAFT WITH HYDROCOLLOID AND STAPLES (1996)

For more than 70 years Plastic and Reconstructive Surgery® has been the one consistently excellent reference for every specialist who uses plastic surgery techniques or works in conjunction with a plastic surgeon. The journal brings readers up-to-the-minute reports on the latest techniques and follow-up for maxillofacial reconstruction, burn repair, cosmetic reshaping, as well as news on medicolegal issues. The cosmetic section provides expanded coverage on new procedures and techniques.
Interaction of Xenopus Cdc2·Cyclin A1 with the Origin Recognition Complex (2000)

The initiation of DNA replication in eukaryotes is regulated in a minimum of at least two ways. First, several proteins, including origin recognition complex (ORC), Cdc6 protein, and the minichromosome maintenance (MCM) protein complex, need to be assembled on chromatin before initiation. Second, cyclin-dependent kinases regulate DNA replication in both a positive and a negative way by inducing the initiation of DNA replication at G(1)/S transition and preventing further rounds of origin firing within the same cell cycle. Here we characterize a link between the two levels. Immunoprecipitation of Xenopus origin recognition complex with anti-XOrc1 or anti-XOrc2 antibodies specifically co-immunoprecipitates a histone H1 kinase activity. The kinase activity is sensitive to several inhibitors of cyclin-dependent kinases including 6-dimethylaminopurine (6-DMAP), olomoucine, and p21(Cip1). This kinase activity also copurifies with ORC over several fractionation steps and was identified as a complex of the Cdc2 catalytic subunit and cyclin A1. Neither Cdk2 nor cyclin E could be detected in ORC immunoprecipitations. Reciprocal immunoprecipitations with anti-Xenopus Cdc2 or anti-Xenopus cyclin A1 antibodies specifically co-precipitate XOrc1 and XOrc2. Our results indicate that Xenopus ORC and Cdc2 x cyclin A1 physically interact and demonstrate a physical link between an active cyclin-dependent kinase and proteins involved in the initiation of DNA replication.
사례 : 해외 선진기업의 벤치마킹을 통한 글로벌 경쟁력 강화: 효성 중공업 PG의 도요타생산방식 도입 사례를 중심으로 (2011)

국내외 많은 기업들이 글로벌 기업의 성공사례를 조직에 도입하여 변화와 혁신을 시도하였으나 동일한 성과를 획득한 사례는 많지 않다. 타 기업의 사례를 효과적으로 조직 내부로 이전하기 위해서는 보다 구체적인 전략과 실행방법이 고려되어야 하기 때문이다. 이와 같은 상황에서 효성 중공업 PG는 글로벌 경쟁에서 살아남기 위해서 도요타의 핵심역량인 도요타생산방식(Toyota Production System, TPS)을 효율적으로 도입하여 경영혁신을 추구하였다. 본 연구에서 효성 중공업 PG가 글로벌 기업의 성공사례를 벤치마킹하여 도입하고자 전사적인 노력을 기울이고 체계적인 전략을 실행함으로써 TPS를 조직내 체화하여 성과로 연결시키는 과정을 살펴볼 수 있었다. 본 연구를 통해 도전 목표의 구체화, 경영진의 적극적인 참여와 지원, 전담조직 구성 및 외부자문 도입, 직원들의 교육과 훈련 강화 및 평가와 보상제도의 구체화 등이 성공사례의 성공적인 이전과 확산에 중요한 요소임을 알 수 있었다.
Creating consistent scene graphs using a probabilistic grammar (2014)

Growing numbers of 3D scenes in online repositories provide new opportunities for data-driven scene understanding, editing, and synthesis. Despite the plethora of data now available online, most of it cannot be effectively used for data-driven applications because it lacks consistent segmentations, category labels, and/or functional groupings required for co-analysis. In this paper, we develop algorithms that infer such information via parsing with a probabilistic grammar learned from examples. First, given a collection of scene graphs with consistent hierarchies and labels, we train a probabilistic hierarchical grammar to represent the distributions of shapes, cardinalities, and spatial relationships of semantic objects within the collection. Then, we use the learned grammar to parse new scenes to assign them segmentations, labels, and hierarchies consistent with the collection. During experiments with these algorithms, we find that: they work effectively for scene graphs for indoor scenes commonly found online (bedrooms, classrooms, and libraries); they outperform alternative approaches that consider only shape similarities and/or spatial relationships without hierarchy; they require relatively small sets of training data; they are robust to moderate over-segmentation in the inputs; and, they can robustly transfer labels from one data set to another. As a result, the proposed algorithms can be used to provide consistent hierarchies for large collections of scenes within the same semantic class.