gebhart/patrepeval huggingface dataset:
Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation (2005)

Human placenta-derived mononuclear cells (MNC) were isolated by a Percoll density gradient and cultured in mesenchymal stem cell (MSC) maintenance medium.The homogenous layer of adherent cells exhibited a typical fibroblastlike morphology,a large expansive potential,and cell cycle characteristics including a subset of quiescent cells.In vitro differentiation assays showed the tripotential differentiation capacity of these cells toward adipogenic,osteogenic and chondrogenic lineages.Flow cytometry analyses and immunocytochemistry stain showed that placental MSC was a homogeneous cell population devoid of hematopoietic cells,which uniformly expressed CD29,CD44,CD73,CD 105,CD166,laminin,fibronectin and vimentin while being negative for expression of CD31,CD34,CD45 and α-smooth muscle actin.Most importantly,immuno-phenotypic analyses demonstrated that these cells expressed class I major histocompatibility complex (MHC-Ⅰ),but they did not express MHC-Ⅱ molecules.Additionally these cells could suppress umbilical cord blood (UCB) lymphocytes proliferation induced by cellular or nonspecific mitogenic stimuli.This strongly implies that they may have potential application in allograft transplantation.Since placenta and UCB are homogeneous,the MSC derived from human placenta can be transplanted combined with hematopoietic stem cells (HSC) from UCB to reduce the potential graft-versus-host disease (GVHD) in recipients.
Book Reviews (1979)

Book Reviews Get access Droit du Travail . By JEAN-CLAUDE JAVILLIER . [ Paris : Librairie Générale de Droit et de Jurisprudence . vi, 634 p. With Mise à Jour to June 1, 1978 . 170 frs.] O. K.-F. O. K.-F. Search for other works by this author on: Oxford Academic Google Scholar Industrial Law Journal, Volume 8, Issue 1, 1979, Pages 252–253, https://doi.org/10.1093/ilj/8.1.252 Published: 01 June 1979
Report on Phosphoric Acid (1940)

Journal Article Report on Phosphoric Acid Get access William H Ross, William H Ross Associate Referee Bureau of Agricultural Chemistry and Engineering, Washington, D. C Search for other works by this author on: Oxford Academic Google Scholar L F Rader, Jr. L F Rader, Jr. Bureau of Agricultural Chemistry and Engineering, Washington, D. C Search for other works by this author on: Oxford Academic Google Scholar Journal of Association of Official Agricultural Chemists, Volume 23, Issue 2, 1 May 1940, Pages 234–242, https://doi.org/10.1093/jaoac/23.2.234 Published: 21 February 2020
The Chlorine-Sensitized Photochemical Oxidation of Gaseous Chloroform (1935)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chlorine-Sensitized Photochemical Oxidation of Gaseous ChloroformAlan T. ChapmanCite this: J. Am. Chem. Soc. 1935, 57, 3, 416–419Publication Date (Print):March 1, 1935Publication History Published online1 May 2002Published inissue 1 March 1935https://doi.org/10.1021/ja01306a008RIGHTS & PERMISSIONSArticle Views83Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (399 KB) Get e-Alerts Get e-Alerts
Threshold-Based Media Streaming Optimization for Heterogeneous Wireless Networks (2010)

The integration of different wireless access technologies combined with the huge characteristic diversity of supported services in next-generation wireless systems creates a real heterogeneous network. In this paper, we propose a generic practical framework that optimizes media streaming in heterogeneous systems by taking advantage of cost and resource characteristic diversity of the integrated access technologies and the buffering capability of streaming applications. The proposed optimization framework represents a means to compromise the tradeoff between different performance metrics including streaming monetary cost, signaling load, and session quality. Additionally, it accommodates different design challenges including mobility randomness, limited processing capacity, and handoff delay requirements. The simulation results provide important insights on the design of pricing profiles in integrated systems. Additionally, the results show that significant cost savings can be realized using the newly proposed streaming management algorithms and optimization framework.
Preparation of powder cellulose (2009)

Powder cellulose was obtained according to the scheme of hydrolysis-bleaching from the wood technical (unbleached) sulfate cellulose. In the first step, from the crude cellulose lignocellulose material was obtained, which in the second step was subjected to delignification by treating with hydrogen peroxide and chlorine dioxide.
Effects of Visual Elements into the Touch Interaction during the Drag Operation (2014)

The tablet PC or smartphone, that a physical interface is minimized, operating at just the touch panel is increased. Furthermore, the display unit and operation unit are the same positions are common and can be operated by touching the same as the like button reality. However, to tap the screen flat, even or tracing, operation feeling obtained from the haptic of the fingertip is small. It is considered that the visual elements displayed on the screen, which affects the operation feeling, put in when the drag operation on the touch panel, to clarify the relationship between the operational feeling and visual elements.
A Caching NFS Client for Linux (1999)

The Linux NFS client su#ers from poor performance. As Linux has become more popular, its primitive NFS client implementation has outgrown its usefulness. We describe numerous enhancements to the Linux NFS client that improve performance. Specifically, we discuss better lookup and attribute caching, asynchronous writing of data, and local disk caching of data file reads. We describe our implementation, and benchmark its performance against both the existing stable Linux NFS client and the local-disk filesystem, ext2fs. Our implementation outperforms the 2.0.x kernel&apos;s NFS client in all but one benchmark, and improves on the basic client by up to a factor of 14 when reading from files that are cached locally. 1 Introduction Unlike more advanced Network File System (NFS) client implementations, such as those by Sun Microsystems for SunOS and Solaris, the Linux 2.0.x NFS client has few performance features. Only asynchronous read-ahead bu#ering and some rudimentary lookup attribut...
A CMIS-capable scripting language and associated lightweight protocol for TMN applications (1996)

In the absence of standards for the telecommunication management network (TMN) F interface, interoperability of workstation applications can be based on the Q3 interface; Common Management Information System (CMIS)-capable interpreted scripting languages and associated lightweight string-based protocols can support the rapid construction of lightweight, portable TMN workstations.
Protection of Ischemia-Reperfusion Injury by Sydnonimine NO Donors via Inhibition of Neutrophil-Endothelium Interaction (1993)

Ischemia of a vascular bed followed by re-establishment of blood flow results in an accelerated and severe form of tissue injury known as “reperfusion injury.” We have investigated reperfusion injury in cats subjected to either myocardial ischemia-reperfusion or splanchnic ischemia-reperfusion. In both cases, a critical early event after reperfusion is endothelial dysfunction characterized by reduced release of endothelium-derived relaxing factor now known to be nitric oxide (NO). Endothelial dysfunction leads to adherence of polymorphonuclear (PMN) leukocytes to the dysfunctional endothelium. Infusion of a sydnonimine NO donor (C87–3754), but not a similar compound lacking the NO moiety (C88–3934), just before reperfusion protected in both forms of ischemia-reperfusion. In the first case, C87–3754, but not C88–3934, attenuated myocardial necrosis, and in the second case, the NO donor improved survival and moderated the indices of shock. In both cases, C87–3754 preserved the endothelium of the ischemic-reperfused vasculature and exerted anti-PMN effects (i.e., reduced PMN adherence to the endothelium or attenuated PMN release of superoxide radicals). Thus, an NO donor infused at a rate calculated to replace the lost NO from the vascular endothelium of the ischemic region exerts significant protective effects on reperfusion of that ischemic vascular bed.
Perfil pressórico e glicêmico dos funcionários dos postos fiscais da Secretaria de Fazenda do Estado de Mato Grosso (2008)

Objective: To evaluate the plasma glucose and blood pressure of the servers of the Secretary of Finances of Mato Grosso and identify new cases of hypertension and DM. Materials and methods: 125 volunteers between 18 and 68 years participate of the study. We evaluated the Blood Pressure (BP) and capillary glucose level (CGL). The results were statistically treated by a calculation of absolute and relative frequency. It was also, the association between blood glucose and BP with the variables: gender and age by means of tests X2 (gender) and X2 for linear trend (age). Results: There was no statistically significant association between PA and changed gender and age. For Glycemia no significant difference between genders and higher levels of Glucose, but the differences are significant for age. When the age increases the evidence of blood glucose changes is higher. Discussion: The CGL showed higher values in line with increasing age which contradicts the findings of the proposed literature. Already the PA was not influenced by gender, which is confirmed by SBH. While age had no relationship with the increase in the PA, it can be explained by the high level of education, good purchasing power of participants and also for a drug treatment done correctly. We observed the importance of testing periodically the levels of blood glucose and the measurement of the PA for the prevention, treatment and discovery of new cases of hypertension and DM.
Anti-Cancer Activities of 1,4-Naphthoquinones: A QSAR Study (2006)

Quinone moieties are present in many drugs such as anthracyclines, daunorubicin, doxorubicin, mitomycin, mitoxantrones and saintopin, which are used clinically in the therapy of solid cancers. The cytotoxic effects of these quinones are mainly due to the following two factors: (i) inhibition of DNA topoisomerase-II and, (ii) formation of semiquinone radical that can transfer an electron to oxygen to produce super oxide, which is catalyzed by flavoenzymes such as NADPH-cytochrome-P-450 reductase. Both semiquinone and super oxide of quinones can generate the hydroxyl radical, which is the cause of DNA strand breaks. 1,4-naphthoquinone contains two quinone groups that have the ability to accept one or two electrons to form the corresponding radical anion or di-anion species. It is probably dependent on the quinone redox cycling that yields "reactive oxygen species" (ROS) as well as arylation reactions, which is common to quinones for biological relevance. In the present review, an attempt has been made to collect the cytotoxicity data on different series of 1,4-naphthoquinones against four different cancer cell lines that are L1210, A549, SNU-1, and K562, which were acquired by using identical method, and has been discussed in terms of QSAR (quantitative structure-activity relationships) to understand the chemical-biological interactions. QSAR results have shown that the cytotoxic activities of 1,4-naphthoquinones depend largely on their hydrophobicity.
The Discovery and Structure-Activity Relationships of 1,2,3,6-Tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine Autoreceptor Agonists and Potential Antipsychotic Agents (1994)

A novel dopamine (DA) autoreceptor agonist, 1,2,3,6-tetrahydro-4-phenyl-1- [(3-phenyl-3-cyclohexen-1-yl)methyl]pyridine (14), was identified. The structure-activity relationships surrounding this compound were studied by synthesis of analogues and evaluation of their dopaminergic activity. The cyclohexene substitution pattern was varied along with the length of the chain connecting the 1,2,3,6-tetrahydro-4-phenylpyridine to the cyclohexene. Compound 14, having the 1,3-substitution pattern and a single methylene chain, was the most potent. The 1,2,3,6-tetrahydro-4-phenylpyridine could be replaced by other aryl-cyclic amines with a slight loss in activity. The phenyl group on the cyclohexene ring could be para substituted; electron-donating groups were better tolerated than electron-withdrawing groups. Finally, the enantiomers of 14 were resolved via the 1,1'-binaphthyl-2,2'-diyl hydrogen phosphate salts. Although both isomers were partial DA agonists, the (+)-enantiomer had higher intrinsic activity than the (-)-enantiomer. Syntheses were developed that allowed rapid preparation of analogues. An X-ray crystal structure determination of an intermediate identified the (+)-isomer of 14 as having R configuration. This compound, designated CI-1007 (PD 143188), was found to have antipsychotic-like activity in behavioral tests; in particular, it was orally active in the conditioned avoidance test in squirrel monkeys with an ED50 of 0.6 mg/kg. The overall profile suggests that (R)-(+)-14 may be a clinically useful antipsychotic agent.
Preparation and properties of porous microspheres made from borate glass (2008)

Dysprosium lithium-borate glass microspheres and particles, ranging from 45 to 150 microm in diameter, were reacted with a 0.25 M phosphate solution at 37 degrees C, whose pH was either 3 or 8.8. The glass reacted nonuniformly and was converted into a porous, amorphous, hydrated, dysprosium phosphate reaction product. The amorphous product had the same volume and shape (pseudomorphic) as the unreacted glass, and could be dried without cracking. After heating at 300 degrees C for 1 h, the amorphous reaction product had a specific surface area of approximately 200 m(2)/g, a pore size of approximately 30 nm, and nominal crushing strength of approximately 10 MPa. When the reaction product was heated to 600 degrees C for 15 min, the specific surface area decreased to approximately 90 m(2)/g and the nominal crushing strength increased to 35 MPa. Heating above 615 degrees C converted the amorphous dysprosium phosphate product into crystalline DyPO(4), which contained open porosity until heated above 800 degrees C for 15 min. Highly porous materials of different chemical composition can be prepared by chemically reacting a borate-based glass with an aqueous solution at low-temperature (<100 degrees C). These highly porous materials are easy to process, and are considered candidates for controlled drug delivery, catalysis, chromatographic separation, filtration, and as bioactive materials.
Detecting Insulin Resistance in Polycystic Ovary Syndrome: Purposes and Pitfalls (2004)

Approximately 50% to 70% of all women with polycystic ovary syndrome (PCOS) have some degree of insulin resistance, and this hormone insensitivity probably contributes to the hyperandrogenism that is responsible for the signs and symptoms of PCOS. Although uncertainty exists, early detection and treatment of insulin resistance in this population could ultimately reduce the incidence or severity of diabetes mellitus, dyslipidemia, hypertension, and cardiovascular disease. Even if that proves to be the case, there are still several problems with our current approach to insulin sensitivity assessment in PCOS, including the apparent lack of consensus on what defines PCOS and "normal" insulin sensitivity, ethnic and genetic variability, the presence of other factors contributing to insulin resistance such as obesity, stress, and aging, and concern about whether simplified models of insulin sensitivity have the precision to predict treatment needs, responses, and future morbidity. Although the hyperinsulinemic-euglycemic clamp technique is the gold standard for measuring insulin sensitivity, it is too expensive, time-consuming, and labor-intensive to be of practical use in an office setting. Homeostatic measurements (fasting glucose/insulin ratio or homeostatic model assessment [HOMA] value) and minimal model tests (particularly the oral glucose tolerance test [OGTT]) represent the easiest office-based assessments of insulin resistance in the PCOS patient. The OGTT is probably the best simple, office-based method to assess women with PCOS because it provides information about both insulin resistance and glucose intolerance. The diagnosis of glucose intolerance holds greater prognostic and treatment implications. All obese women with PCOS should be screened for the presence of insulin resistance by looking for other stigmata of the insulin resistance syndrome such as hypertension, dyslipidemia, central obesity, and glucose intolerance.
The pathophysiology of hypertension (2001)

There is still much uncertainty about the pathophysiology of hypertension. A small number of patients (between 2% and 5%) have an underlying renal or adrenal disease as the cause for their raised blood pressure. In the remainder, however, no clear single identifiable cause is found and their condition is labelled “essential hypertension”. A number of physiological mechanisms are involved in the maintenance of normal blood pressure, and their derangement may play a part in the development of essential hypertension.

This article has been adapted from the newly published 4th edition of ABC of Hypertension . The book is available from the BMJ bookshop and at http://www.bmjbooks.com/



The relative frequency of primary and secondary hypertension



It is probable that a great many interrelated factors contribute to the raised blood pressure in hypertensive patients, and their relative roles may differ between individuals. Among the factors that have been intensively studied are salt intake, obesity and insulin resistance, the renin-angiotensin system, and the sympathetic nervous system. In the past few years, other factors have been evaluated, including genetics, endothelial dysfunction (as manifested by changes in endothelin and nitric oxide), low birth weight and intrauterine nutrition, and neurovascular anomalies.

#### Physiological mechanisms involved in development of essential hypertension

Maintenance of a normal blood pressure is dependent on the balance between the cardiac output and peripheral vascular resistance. Most patients with essential hypertension have a normal cardiac output but a raised peripheral resistance. Peripheral resistance is determined not by large arteries or the capillaries but by small arterioles, the walls of which contain smooth muscle cells. Contraction of smooth muscle cells is thought to be related to a rise in intracellular calcium concentration, which may explain the vasodilatory …
Stereodivergent Total Synthesis of Δ<sup>9</sup>‐Tetrahydrocannabinols (2014)

All four stereoisomers of Δ(9)-tetrahydrocannabinol (Δ(9)-THC) were synthesized in concise fashion using stereodivergent dual catalysis. Thus, following identical synthetic sequences and applying identical reaction conditions to the same set of starting materials, selective access to the four stereoisomers of THC was achieved in five steps.
Retracted Article: Efficient microwave-promoted acrylonitrile sustainable synthesis from glycerol (2009)

Solvent-free microwave-activation, in the liquid phase using an alumina supported V-Sb-O catalyst, affords highly efficient conversion (47%) of glycerol into acrylonitrile under mild conditions, short reaction times and in the absence of any solvent; in addition, it increases selectivity (>80%) compared to conventional thermal activation.
MILA - A noise mitigation technique for RF power amplifier linearization (2014)

Standard indirect learning architecture (ILA) based methods for estimating the parameters in digital pre-distortion produce biased estimates of the parameters due to noise. This paper proposes using a direct model of the power amplifier to generate a noise-free estimate of the output signal and subsequently use this estimated signal to extract the parameters of the pre-distorter using the ILA. Measurement results shows that this technique improves the performance of the pre-distorter for all signal-to-noise ratios, but especially in the range of 20-30 dB signal-to-noise ratio.
Evaluation of Myocardial Bridge With Multidetector Computed Tomography (2009)

The incidence of MB and its anatomical properties can be evaluated with MDCT, which might be a useful and noninvasive method of detecting this variant. (Circ J 2010; 74: 137 - 141).
Relaxin, a Potent Microcirculatory Effector, Is Not Angiogenic (1996)

The ability of relaxin (RLX), which is a potent microcirculatory effector in many species including the rat, to induce de novo angiogenesis in vascularized mammalian tissue was tested using the rat mesenteric-window angiogenesis assay. RLX was administered intraperitoneally on days 1-5 at doses of 0.33, 3.3 and 33 nM. Controls received the vehicle by the same route. Groups of animals were sacrificed at the end of the 1st, 2nd and 3rd weeks. Using computer-aided microscopic morphometry including image analysis, the response was quantified by sensitive, technically independent, highly reproducible methods in terms of the vascularized area (VA), a measure of microvascular spatial extension, and the microvascular length (MVL), a measure of microvascular density. The total MVL was computed from VA x MVL. The results obtained show that RLX did not cause significant changes in any of the variables tested, regardless of dose and observation time. These findings indicate that RLX is apparently unable to mediate significant de novo angiogenesis in the system used in contrast to previously tested angiogens such as basic fibroblast growth factor, vascular endothelial growth factor, isoform 165, and tumor necrosis factor-alpha. In previous studies, RLX has been shown to exert antitumor activity on breast cancer cells in vitro. In the search for a possible role for RLX as an anticancer agent in vivo, it is important to know that this peptide is not angiogenic, since de novo angiogenesis is known to be a prerequisite for tumor growth and metastatic spread.