gebhart/patrepeval huggingface dataset:
Expression analysis of LC3B and p62 indicates intact activated autophagy is associated with an unfavorable prognosis in colon cancer (2017)

Autophagy is a lysosomal degradation and recycling process implicated in cancer progression and therapy resistance. We assessed the impact of basal autophagy in colon cancer (CC) <i>in vitro</i> and <i>ex vivo</i>. Functional autophagy was demonstrated in CC cell lines (LoVo; HT-29) showing a dose-dependent increase of the autophagy markers LC3B, p62 and autophagic vesciles upon increasing concentrations of the autophagy inhibitor chloroquine, which was demonstrated by immunoblotting, immunofluorescence and electron microscopy. Next, tissue microarrays with 292 primary resected CC, with cores from different tumor regions, and normal mucosa were analyzed by immunohistochemistry for LC3B and p62. CC tissue showed LC3B dot-like, p62 dot-like, cytoplasmic and nuclear staining in various levels without significant intratumoral heterogeneity. Tumoral LC3B and p62 expression was significantly higher than in normal tissue (p<0.001). No associations between staining patterns and pathological features (e.g. TNM categories; grading) were observed. Both low LC3B dot-like and low p62 dot-like-cytoplasmic staining were associated with worse overall survival (p=0.005 and p=0.002). The best prognostic discrimination, however, was seen for a combination of LC3B dot-like/p62 dot-like-cytoplasmic staining: high expression of both markers, indicative of impaired activated autophagy, was associated with the best overall survival. In contrast, high LC3B dot-like/low p62 dot-like-cytoplasmic expression, indicative of intact activated autophagy, was associated with the worst outcome (p<0.001 in univariate and HR=0.751; CI=0.607-0.928; p=0.008 in multivariate analysis). These specific expression patterns of LC3B and p62 pointing to different states of autophagy associated with diverging clinical outcomes highlighte the potential significance of basal autophagy in CC biology.
ACUTE RETROBULBAR NEURITIS AFFECTING THE OPTIC CHIASMA AND TRACT (1925)

IHAr the condition with which ophthalmologists are familiar as acute retrobulbar neuritis may have its site in the chiasma or tract has been established by Roenne(" 2), but up to the present little notice has been taken'in this country of this form of an otherwise common disease. Its recognition is of value in connec- tion with the diagnosis of affections of the subgeniculate visual pathway and the cases which follow are therefore recorded in some detail.
Microvascular integrity indicates myocellular viability in patients with recent myocardial infarction. New insights using myocardial contrast echocardiography. (1994)

In patients studied in the cardiac catheterization laboratory between 1 day and 4 weeks after AMI, an intact microvasculature as identified by MCE indicates myocardial regions that improve function 1 month later. This study demonstrates that microvascular patency is closely associated with myocardial cellular viability after AMI in humans.
It's a bug's life: biosensors for environmental monitoring (2003)

After many years of development, biosensors have begun to move out of the laboratory and into commercial applications. Combining advances in biotechnology, nanotechnology and information processing, these novel devices promise to open the door to many exciting new environmental monitoring solutions.
Immunity to the 6C3HED Ascites Tumor Following Treatment of Tumor-Bearing Mice with <i>Escherichia coli</i> L-Asparaginase (1967)

Summary Long-lived immunity to the 6C3HED ascites lymphosarcoma in C3H/HE mice following treatment of the tumor-bearing animals with Escherichia coli L-asparaginase has been observed. This tumor which had its origin in C3H mice is normally lethal for this strain. Immunity of C3H/HE mice was demonstrated by (1) tumor rejection, (2) neutralization of tumor cells by immune serum and lymphoid extract, and (3) in vitro cytotoxicity of the same preparations. Adsorption experiments with normal C3H/HE lymphatic cells and 6C3HED-OG tumor cells indicate that the immune response in C3H/HE mice is directed against an antigen unique for the tumor cells. This point was underscored by the decrease in cytotoxicity and neutralizing activity of immune C57BL serum following adsorption with normal C3H/HE lymphatic cells. In these mice the immune response was directed primarily against histoincompatibility antigens. When tumor-bearing C3H/HE mice were treated with 6-mercaptopurine and asparaginase, the primary immune response was blocked, and the mice were unable to reject a subsequent implant of 6C3HED cells. C3H/HE mice rendered immune to the 6C3HED-OG tumor following asparaginase therapy were also immune to the asparaginase-resistant 6C3HED-RG1 lymphosarcoma.
Activated Expression of the N- <i>myc</i> Gene in Human Neuroblastomas and Related Tumors (1984)

In neuroblastoma lines in which the N- myc gene is present as a single copy, the expression of N- myc as messenger RNA is increased relative to that in nonneuroblastoma cell lines and tumors. The increase of expression in neuroblastomas with amplified N- myc genes is the result of (i) an increase in the absolute amount of expression of each N- myc gene and (ii) an increase in the copy number of the N- myc gene. A second gene—which is amplified in many of the same lines as N- myc —is expressed to about the same degree in most human cell lines and primary tumors regardless of origin (when normalized to gene copy number). Thus, a change in the regulation of N- myc expression in neuroblastomas and certain other tumors results in greatly increased expression of each N- myc gene copy.
X-ray irradiation effects on fluorine-doped germanosilicate optical fibers (2014)

International audience; We report an experimental investigation on the effects of fluorine codoping on the radiation response of Ge-doped Optical Fibers (OFs) obtained by three different drawing conditions. The OFs were irradiated with 10 keV X-rays up to 300 Mrad and studied by online Radiation-Induced-Attenuation (RIA) measurements. Confocal Micro- Luminescence (CML) and Electron Paramagnetic Resonance (EPR) were also employed to investigate the permanent radiation-induced-defects. The variation of the Germanium-Lone-Pair-Center (GLPC) and Non-Bridging- Oxygen-Hole-Centers (NBOHC) concentration with the radiation dose is investigated by CML, whereas the ones of the induced Ge(1), Ge(2) and Eʹ centers by EPR. No relevant differences are found in the RIA of the three fibers, as well as in the induced concentrations of Ge(1) and Ge(2) and in the decrease of the GLPC, showing minor relevance of changing the drawing conditions. We found that fluorine codoping does not affect the RIA and that, unexpectedly, the fluorine co-doped zones of the OFs show an enhanced photoluminescence of the radiation induced NBOHC enabling to suggest the presence of both Si and Ge variants. Moreover, an overall increase of the radiation induced Eʹ(Ge) centers is registered in relation to the presence of fluorine showing that this codopant has relevant effects.
Quantum Chemical Calculation on the Desulfurization Reactivities of Heterocyclic Sulfur Compounds (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantum Chemical Calculation on the Desulfurization Reactivities of Heterocyclic Sulfur CompoundsXiaoliang Ma, Kinya Sakanishi, Takaaki Isoda, and Isao MochidaCite this: Energy Fuels 1995, 9, 1, 33–37Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/ef00049a005https://doi.org/10.1021/ef00049a005research-articleACS PublicationsRequest reuse permissionsArticle Views451Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sodium Lauryl Sulfate-Induced Irritation in the Human Face: Regional and Age-Related Differences (2006)

The particular sensitivity of the human face to care products prompted us to study irritation induced by sodium lauryl sulfate (SLS) in its various regions. We examined regional and age-related differences, correlating basal transepidermal water loss (TEWL) and capacitance to SLS irritation. SLS (2% aq.) was applied under occlusion for 1 h to the forehead, cheek, nose, nasolabial and perioral areas, chin, neck and forearm to two groups of subjects--one with 10 subjects with an average age of 25.2 +/- 4.7 years and another with 10 subjects with an average age of 73.7 +/- 3.9 years. TEWL was measured before and 1 h and 23 h after patch removal. Baseline stratum corneum hydration was also measured. Irritation was assessed by the changes in TEWL (deltaTEWL = TEWL after patch removal - basal TEWL) after corrections to the control. In the younger group, all areas of the face and the neck reacted to SLS, whereas the forearm did not. In the older group, the nose, perioral area and forearm did not react. In both age groups, some significant differences between the regions of the face were detected. The younger group showed higher changes in TEWL than the older group in all the areas studied, but only in the chin and nasolabial area were the differences statistically significant. Significant correlations were found between basal TEWL and deltaTEWL in 5 of the 7 areas which reacted to SLS. Baseline TEWL is one parameter that correlates with the susceptibility of the face to this irritant.
High-transconductance insulating-gate InP/InGaAs buried p-buffer DH-MODFETs grown by MOVPE (1989)

Buried p-buffer double heterostructure modulation-doped field-effect transistors (BP DH-MODFETs) with an InGaAs quantum-well channel were fabricated with high transconductance and good breakdown voltage, by placing the metal gate directly on Fe-doped InP insulating layer. Excellent extrinsic DC transconductance of 560 mS/mm and a high gate-to-drain diode breakdown voltage (greater than 20 V) were achieved at room temperature with FETs of 1.2- mu m gate length. Unity currently gain cutoff frequency f/sub T/ of 24 GHz and maximum oscillation frequency f/sub max/ of 60 GHz were demonstrated for a drain to source voltage V/sub DS/=4 V, which corresponds to an average electron velocity of 2.2*10/sup 7/ cm/s in the quantum well.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cell wall fragments from major residents of the human intestinal flora induce chronic arthritis in rats. (1989)

To investigate the involvement of human intestinal flora in joint inflammation, cell wall fragments of 9 anaerobic gram positive bacteria of the human fecal flora were prepared and tested for arthropathic properties in the rat. A single intraperitoneal injection of cell wall fragments from Eubacterium aerofaciens or Bifidobacterium species induced persistent chronic arthritis, in contrast to those from Eubacterium rectale, Clostridium species and Lactobacillus leichmanii. The results show that cell wall fragments of major residents from the human fecal flora can induce chronic arthritis in the rat and support the hypothesis that normal human intestinal flora plays a role in the induction of arthritis in man.
IMMUNOMODULATORS: A PHARMACOLOGICAL REVIEW (2012)

Immunology is one of the most rapidly developing areas of medical biotechnology research and has great promises with regard to the prevention and treatment of a wide range of disorders such as the inflammatory diseases of skin, gut, respiratory tract, joints and central organs. In addition, infectious diseases are now primarily considered immunological disorders, while neoplastic diseases and organ transplantation and several autoimmune diseases are involved in an immunosuppressive state. Immunomodulators are natural or synthetic substances that help regulate or normalize the immune system. Immunomodulators correct immune systems that are out of balance. Natural immunomodulators are less potent than prescription immunomodulators and also less likely to cause side effects. Prescription synthetic immunomodulator medications, such as azathioprine, 6-mercaptopurine, methotrexate, and mycophenolate mofetil, work by suppressing the immune system and decreasing inflammation in the digestive tract in people with inflammatory bowel disease, ulcerative colitis, and Crohn's disease. The benefits of immunomodulators stem from their ability to stimulate natural and adaptive defense mechanisms, such as cytokines, which enables the body to help itself. There are two types of immunomodulators: immunosuppressants and immunostimulants. Immunosuppressants are the agents which suppress the immune system and are used for the control of pathological immune response in autoimmune disease, graft rejection etc. Immunostimulants are the agents which are envisaged to enhance body's resistance against infections; they enhance the basal levels of immune response, and in individuals with impairment of immune response as immunotherapeutic agent. A number of disorders such as immunodeficiency state, autoimmune disease, cancer and viral infection can be treated with immunostimulants drugs. Immunomodulators are becoming a viable adjunct to established modalities offering a novel approach for the treatment of infectious disease in the coming decades of 21 st century
Anticandidal activities of terconazole, a broad-spectrum antimycotic (1986)

Terconazole is a new triazole ketal derivative with broad-spectrum in vitro and in vivo antifungal activities. This study further characterizes the effects of terconazole in vitro on yeast cell growth, viability, and morphology. Terconazole inhibited the growth of Candida albicans ATCC 44859 in a concentration-related manner, but with modest effects noted at levels from 10(-8) to 10(-5) M when the yeast was grown on media favoring the cell form. The inhibitory potency of terconazole on yeast cell viability varied with the strain and species of Candida tested. The susceptibility of C. albicans ATCC 44859 to terconazole was markedly enhanced when the yeast was grown on Eagle minimum essential medium, which favors mycelium formation. The effects of terconazole on the morphology of yeast cells (grown on Eagle minimum essential medium) were shown by phase-contrast and electron microscopy. There is a progression of changes, from loss of mycelia formation at 10(-8) M terconazole through complete necrosis at 10(-4) M.
Male‐to‐male transmission of mild Bachmann‐de Lange syndrome (1994)

We report on a father and son with mild Brachmann-de Lange syndrome. Previous reports have documented apparent autosomal dominant transmission; however, only one example of male-to-male transmission of possible Brachmann-de Lange syndrome has been reported. This case provides further evidence of the existence of an autosomal dominant form of Brachmann-de Lange syndrome.
Investigation of the Effect of Target Water Content on a Laser-Induced Plasma (1997)

Because of difficulties with matrix matching in a number of laser solid sampling techniques, plasma diagnostics are often employed directly or indirectly (through internal standardization) as a means of generating working curves. In this study, the effects of water content of CaCO 3 powder on size, shape, excitation temperature, electron number density, continuum emission, and line emission of plasmas generated on the powder are investigated. Although the specific wetting properties of the matrix will determine the magnitude of the water content effects, the observations made for CaCO 3 powder indicate that emission and electron number density are the two parameters affected significantly by water content, both decreasing with increasing weight % water. In laser-induced breakdown spectroscopy of samples that may have an inhomogeneous distribution of water or of samples in which water content can vary significantly, accounting for the effects of this water is essential to an accurate analysis.
Cosmetic Oculoplastic Surgery (1984)

A concise review of oculoplastic techniques for general ophthalmologists by known experts in the field, the book details the latest information on cosmetic surgery of the eyelids, eyebrows, and forehead. It provides thorough documentation of the results, an explanation of complications, pre- and postoperative photographs, and selected references. Also discussed are such issues as history, psychiatry, cosmetology, anesthesia, patient satisfaction and dermapathology.
Molecular cloning of Mus dunni endogenous virus: an unusual retrovirus in a new murine viral interference group with a wide host range (1997)

Mus dunni endogenous virus (MDEV) is activated from cells of the Asian wild mouse M. dunni (also known as Mus terricolor) in response to treatment with either 5-iodo-2'-deoxyuridine or hydrocortisone. MDEV represents a new murine retrovirus interference group and thus appears to use a different receptor for entry into cells than do other murine retroviruses. Here we show that MDEV is also not in the gibbon ape leukemia virus or RD114 virus interference groups. A retroviral vector with an MDEV pseudotype was capable of efficiently infecting a wide variety of cells from different species, indicating that the MDEV receptor is widely expressed. We isolated a molecular clone of this virus which exhibited no hybridization to any cloned retrovirus examined, suggesting that MDEV has an unusual genome. One copy of a possible retrovirus element that weakly hybridized with MDEV was present in the genomes of laboratory strains of mice, while no such elements were present in other species examined. A virus activated by 5-iodo-2'-deoxyuridine from cells of a BALB/c mouse, however, was not related to MDEV by either hybridization or interference analyses.
White light‐emitting diodes: History, progress, and future (2017)

Abstract About twenty years ago, in the autumn of 1996, the first white light‐emitting diodes (LEDs) were offered for sale. These then‐new devices ushered in a new era in lighting by displacing lower‐efficiency conventional light sources including Edison's venerable incandescent lamp as well as the Hg‐discharge‐based fluorescent lamp. We review the history of the conception, improvement, and commercialization of the white LED. Early models of white LEDs already exceeded the efficiency of low‐wattage incandescent lamps, and extraordinary progress has been made during the last 20 years. The review also includes a discussion of advances in blue LED chips, device architecture, light extraction, and phosphors. Finally, we offer a brief outlook on opportunities provided by smart LED technology. image
Influence of 2,4-D and BAP on callus growth and the subsequent regeneration of somatic embryos in long-term cultures of Pelargonium x domesticum cv. Madame Layal (2007)

This long-term study demonstrates for the first time that it is possible to propagate embryogenic cultures in pelargoniums and to subsequently initiate the differentiation of embryos using the cultivar Madame Layal ( Pelargonium x domesticum ). Propagation of callus was only possible with combinations of 2,4-dichlorophenoxyacetic acid (2,4-D) and 6-benzylaminopurine (BAP), which gave rise to embryos from the primary culture stage on. However, the propagation of cells, as well as the differentiation of embryos, was inhibited by a continuous application of these growth regulators. For this reason, a long period on medium lacking growth regulators was necessary before the differentiation of embryos occurred again. The consequences for improving the propagation of embryogenic cultures in pelargoniums are discussed.
Point2SpatialCapsule: Aggregating Features and Spatial Relationships of Local Regions on Point Clouds Using Spatial-Aware Capsules (2020)

Learning discriminative shape representation directly on point clouds is still challenging in 3D shape analysis and understanding. Recent studies usually involve three steps: first splitting a point cloud into some local regions, then extracting the corresponding feature of each local region, and finally aggregating all individual local region features into a global feature as shape representation using simple max-pooling. However, such pooling-based feature aggregation methods do not adequately take the spatial relationships (e.g. the relative locations to other regions) between local regions into account, which greatly limits the ability to learn discriminative shape representation. To address this issue, we propose a novel deep learning network, named Point2SpatialCapsule, for aggregating features and spatial relationships of local regions on point clouds, which aims to learn more discriminative shape representation. Compared with the traditional max-pooling based feature aggregation networks, Point2SpatialCapsule can explicitly learn not only geometric features of local regions but also the spatial relationships among them. Point2SpatialCapsule consists of two main modules. To resolve the disorder problem of local regions, the first module, named geometric feature aggregation, is designed to aggregate the local region features into the learnable cluster centers, which explicitly encodes the spatial locations from the original 3D space. The second module, named spatial relationship aggregation, is proposed for further aggregating the clustered features and the spatial relationships among them in the feature space using the spatial-aware capsules developed in this paper. Compared to the previous capsule network based methods, the feature routing on the spatial-aware capsules can learn more discriminative spatial relationships among local regions for point clouds, which establishes a direct mapping between log priors and the spatial locations through feature clusters. Experimental results demonstrate that Point2SpatialCapsule outperforms the state-of-the-art methods in the 3D shape classification, retrieval and segmentation tasks under the well-known ModelNet and ShapeNet datasets.
Analysis of Degradation Phenomenon Caused by Self-Heating in Low-Temperature-Processed Polycrystalline Silicon Thin Film Transistors (2002)

The reliability of low-temperature-processed (≦425°C) polycrystalline-silicon thin film transistors (poly-Si TFTs) was investigated. For n-channel TFTs, the sub-threshold characteristics shifted in the positive direction when a high voltage stress was applied to them, which is particularly significant in small-size TFTs as well as in wide-channel TFTs. It was verified that the temperature of the TFTs reached over 300°C due to self-heating when this stress was applied. We estimate that the breaking of Si–H bonds and re-generation of dangling bonds in the channel poly-Si layers due to self-heating are responsible for the degradation phenomenon.