gebhart/patrepeval huggingface dataset:
Inverter motor with sinusoidal starting currents, a new solution with 2 DC-links only (2002)

Inverter motors need only simple line and machine commutated power converters and have proven good performance for drives in the MW range. They cause high torque ripple, which is disturbing only at low frequencies, and require additional commutation devices under heavy start-up conditions. The also very economic cycloconverters are only useful for machine frequencies up to 40% of line frequency. The new proposed system combines the advantages of both drives with 2 DC links only. The same circuit operates as a cycloconverter at start-up and low frequencies of the motor, and as a current source inverter at high speeds. A switchover from one operation mode to the other without any transient reaction is shown. The additional expenditure compared to the conventional invertor motor is very small.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hypoxia death stimulus induces translocation of p53 protein to mitochondria (2001)

Evidence suggests that p53 induces cell death by a dual mode of action involving activation of target genes and transcriptionally independent direct signaling. Mitochondria are major signal transducers in apoptosis. We recently discovered that a fraction of induced p53 protein rapidly translocates to mitochondria during p53-dependent apoptosis, but not during p53-independent apoptosis or p53-mediated cell cycle arrest. Importantly, specific targeting of p53 to mitochondria was sufficient to induce apoptosis in p53-deficient tumor cells. This led us to propose a model where p53 exerts a direct apoptogenic role at the mitochondria, thereby enhancing the transcription-dependent apoptosis of p53. Here we show for the first time that mitochondrial localization of endogenous p53 can be visualized by immunofluorescence of whole cells when stressed by hypoxic conditions. Suborganellar localization by limited trypsin digestion of isolated mitochondria from stressed cells suggests that a significant amount of mitochondrial p53 is located at the surface of the organelle. This mitochondrial association can be reproduced in vitro with purified p53. Together, our data provide further evidence for an apoptogenic signaling role of p53 protein in vivo at the level of the mitochondria.
Glycogen synthase kinase-3β phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons (2005)

Recent experiments show that the microtubule-associated protein (MAP) 1B is a major phosphorylation substrate for the serine/threonine kinase glycogen synthase kinase-3beta (GSK-3beta) in differentiating neurons. GSK-3beta phosphorylation of MAP1B appears to act as a molecular switch regulating the control that MAP1B exerts on microtubule dynamics in growing axons and growth cones. Maintaining a population of dynamically unstable microtubules in growth cones is important for axon growth and growth cone pathfinding. We have mapped two GSK-3beta phosphorylation sites on mouse MAP1B to Ser1260 and Thr1265 using site-directed point mutagenesis of recombinant MAP1B proteins, in vitro kinase assays and phospho-specific antibodies. We raised phospho-specific polyclonal antibodies to these two sites and used them to show that MAP1B is phosphorylated by GSK-3beta at Ser1260 and Thr1265 in vivo. We also showed that in the developing nervous system of rat embryos, the expression of GSK-3beta phosphorylated MAP1B is spatially restricted to growing axons, in a gradient that is highest distally, despite the expression of MAP1B and GSK-3beta throughout the entire neuron. This suggests that there is a mechanism that spatially regulates the GSK-3beta phosphorylation of MAP1B in differentiating neurons. Heterologous cell transfection experiments with full-length MAP1B, in which either phosphorylation site was separately mutated to a valine or, in a double mutant, in which both sites were mutated, showed that these GSK-3beta phosphorylation sites contribute to the regulation of microtubule dynamics by MAP1B.
Estrogen Receptor, <i>c‐erb</i>B‐2 and <i>nm</i>23/NDP Kinase Expression in the Intraductal and Invasive Components of Human Breast Cancers (1992)

Expression of the c-erbB-2 oncoprotein (ErbB-2) and the nm23 anti-metastatic gene product (nucleoside diphosphate [NDP] kinase) was examined in the intraductal and invasive components of 63 fresh human breast cancer tissues. The expression of estrogen receptor (ER) as a marker of hormone dependency and the Ki-67 protein as a proliferative cell marker was also examined. ErbB-2 and ER were positive in 77.8% (28/36) and 64.7% (22/34) of the intraductal components, and in 43.6% (27/62) and 57.1% (36/63) of the invasive components, respectively. NDP kinase was positive in 58% (18/31) of intraductal, and in 30.9% (17/55) of invasive areas. The average Ki-67-positive cell rates were 5.9% in the intraductal, and 10.7% in the invasive components. Thus, the cells within the intraductal component of breast cancer appear to have different characteristics from the invasive component, not only in markers of proliferative ability, but also in the expression of oncogenes and hormone receptors.
SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer (2016)

SHP2 upregulates the expression and signaling of multiple RTKs to promote BTBC. These findings provide a mechanistic explanation for the superiority of SHP2 inhibition in BTBC.
A Simple Privacy Protecting Scheme Enabling Delegation and Ownership Transfer for RFID Tags (2007)

RFID (Radio frequency identification) technology raises many privacy concerns among which the potential tracking of an RFID tag bearer and the eventuality of an illegitimate reading device (reader) collecting information about him. To solve these issues, many RFID privacy protecting protocols assume that readers have continuous connectivity with a centralised on-line database in charge of the identification of a certain amount of tags. However such centralised models can raise scalability and latency problems. Moreover, they are not suitable in applications where connectivity is intermittent. As RFID tags may often change hands, it is also necessary to guarantee the privacy of a new tag owner. In this paper, we introduce a privacy protecting scheme based on pseudonyms that allows an online database to delegate temporarily and in a secure manner the capability to identify tags to selected readers. A reader which receives delegation for a given tag can identify this tag without referring to the on-line database, thus solving possible intermittent connectivity issues and making tag identification more scalable. Our protocol also manages tags ownership transfer without threatening the new owner’s privacy.
Failure of intravenous infusions in neonates (1991)

The median life expectancy (survival) of 286 peripheral intravenous infusion sites in 105 babies in a children's intensive care unit was 36 h. Unadjusted univariate survival analysis revealed that dextrose infusions and the initial infusions received by a baby had longer survival than total parenteral nutrition (TPN) infusions and later infusions respectively. Also infusions with cloxacillin and penicillin survived for longer than average while infusions with phenytoin had reduced survival. Gestational age, weight, infusion site, other drugs, co-infusion of Intralipid with TPN solutions and neutralization of TPN did not influence survival of infusions. Multivariate survival analysis confirmed the findings for TPN and penicillin but not for cloxacillin, phenytoin or later infusions. Multivariate analysis also suggested that survival was improved with ampicillin and aminophylline and worse for leg sites, for older babies and for infusions in which the fluids were given at greater rates. It also indicated that neutralization of TPN improved survival.
The Effect of Hoichunyanggyuksan on the Anti-allergic Effect, Analgesic Action, Anti-inflammatory Action and Antipyretic Action. (1994)

The Effects of Hoichunyanggyuksan on the Anti-allergic Effect, Analgesic Action, Anti-inflammatory Action and Antipyretic Action. Experimental studies were done to research the clinical effects of Hoichunyanggyuksan on the Anti-allergic effect, Analgesic action, Anti-inflammatory action and Antipyretic action. The results obtained as follows; 1. On vascular permeability responses to intradermal histamine, Hoichnyanggyuksan showed significant effect. 2. In the homologous PCA provoked by the IgE-like antibody against white egg albumin, Hoichunyanggyuksan showed the decreasing tendency, but was none significant effect. 3. In the delayed type hypersensitivity responses to Picryl chloride, Hoichunyanggyuksan was proved significant effect. 4. In the delayed type hypersensitivity resposes to SRBC, Hoichunyanggyuksan revealed significant effect. 5. In Anti-pyretic action by yeast method, Hoichunyanggyuksan showed significant effect. 6. In Anti-inflammatory action by carrageenin method, Hoichunyanggyuksan showed significant effect. 7. In analgesic action by acetic acid method, Hoichunyanggyuksan was recognized significantly.
Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin (1998)

The gastric aspartic proteinases (pepsin A, pepsin B, gastricsin and chymosin) are synthesized in the gastric mucosa as inactive precursors, known as zymogens. The gastric zymogens each contain a prosegment (i.e. additional residues at the N-terminus of the active enzyme) that serves to stabilize the inactive form and prevent entry of the substrate to the active site. Upon ingestion of food, each of the zymogens is released into the gastric lumen and undergoes conversion into active enzyme in the acidic gastric juice. This activation reaction is initiated by the disruption of electrostatic interactions between the prosegment and the active enzyme moiety at acidic pH values. The conversion of the zymogen into its active form is a complex process, involving a series of conformational changes and bond cleavage steps that lead to the unveiling of the active site and ultimately the removal and dissociation of the prosegment from the active centre of the enzyme. During this activation reaction, both the prosegment and the active enzyme undergo changes in conformation, and the proteolytic cleavage of the prosegment can occur in one or more steps by either an intra- or inter-molecular reaction. This variability in the mechanism of proteolysis appears to be attributable in part to the structure of the prosegment. Because of the differences in the activation mechanisms among the four types of gastric zymogens and between species of the same zymogen type, no single model of activation can be proposed. The mechanism of activation of the gastric aspartic proteinases and the contribution of the prosegment to this mechanism are discussed, along with future directions for research.
A discrete numerical model for granular assemblies (1979)

The distinct element method is a numerical model capable of describing the mechanical behaviour of assemblies of discs and spheres. The method is based on the use of an explicit numerical scheme in which the interaction of the particles is monitored contact by contact and the motion of the particles modelled particle by particle. The main features of the distinct element method are described. The method is validated by comparing force vector plots obtained from the computer program BALL with the corresponding plots obtained from a photoelastic analysis. The photoelastic analysis used for the comparison is the one applied to an assembly of discs by De Josselin de Jong and Verruijt (1969). The force vector diagrams obtained numerically closely resemble those obtained photoelastically. It is concluded from this comparison that the distinct element method and the program BALL are valid tools for research into the behaviour of granular assemblies. La méthode des éléments distincts est un modèle numérique capable de décrire le comportement mécanique de l'assemblage de disques et de sphères. La méthode est basée sur l'utilisation d'un système numérique explicite dans lequel l'interaction des particules est contrôlée contact par contact et le mouvement des particules simulé particule par particule. Les caracteristiques principales de la méthode des eléments distints sont décrites. La méthode est validée en comparant les tracés de vecteur de force obtenus par le programme sur ordicateur BALL avec les tracés correspondants obtanus a l'aide d'une analyse photo-élastique. L'analyse photo-élastique utilisée pour la comparaison est celle appliquée sur un assemblage de disques par De Josselin de Jong et Verruijt (1969). Les diagrammes de vecteur de force obtenus numériquement sont très voisins de ceux obtenus photo-élastiquement. Cette comparaison permet de conclure que la methode des éléments distincts et le programme BALL sont des instruments valables pour la recherche du comportement des assemblages granulaires.
Hadamard transform imager and imaging spectrometer (1976)

An imager and a spectrometric imager, which achieve multiplexing by the use of binary optical encoding masks, have been built and tested. The masks are based on orthogonal, pseudorandom digital codes derived from Hadamard matrices. The spatial (and/or spectral) data are therefore obtained in the form of a Hadamard transform of the spatial (and/or spectral) scene; computer algorithms are used to decode the data and reconstruct images of the original scene. The hardware, algorithms processing and display facility are described. A number of spatial and spatial/spectral images, obtained in the laboratory, are presented. We present an analysis of the situations for which the multiplex advantage may be gained and of the limitations of the technique. Potential applications of the spectrometric imager are discussed. The spectrometric imager is covered by U.S. Patent 3,720,469 assigned to Spectral Imaging Inc., Concord, Mass.
Chemical Modification of ε-Amino Groups in Glutamine Synthetase from Bacillus stearothermophilus with Ethyl Acetimidate (1979)

The activity of glutamine synthetase [EC 6·3·2·1] from Bacillus stearothermophilus decreased slightly on modification with ethyl acetimidate. Acetamidination of 25–26 of the 27 ε-amino groups/subunit of the enzyme affected the maximum velocity, but not the Michaelis constant. The thermostability of the enzyme was considerably increased on acetamidination. Acetamidination of the enzyme did not affect the circular dichroism, the tryptophan fluorescence or the quenching effects of KI and acrylamide on the tryptophan emission. The fluorescence spectrum of p-toluidinylnaphthalene sulfonate bound to the enzyme changed on acetamidination.
<i>Escherichia coli</i> O157:H7 as the Predominant Pathogen Associated With the Hemolytic Uremic Syndrome: A Prospective Study in the Pacific Northwest (1987)

During a 12-month period, 14 patients with the hemolytic uremic syndrome were identified in a prospective study of enteric pathogens associated with this disorder. Of the 12 patients with a diarrheal illness preceding the onset of hemolytic uremic syndrome, fecal Escherichia coli O157:H7 was detected in seven (58%), all of whom had bloody diarrhea. Half of the siblings of these patients had concurrent nonbloody diarrhea. No source for infection with this organism was identified. Enteric infection with E coli O157:H7 occurs in the majority of cases of hemolytic uremic syndrome following diarrheal illness in the Pacific Northwest and may represent a previously overlooked cause of hemolytic uremic syndrome in other locales. Evaluation of all cases of hemolytic uremic syndrome for enteric pathogens should routinely include cultures for E coli O157:H7 until results of additional studies clarify the distribution of agents associated with hemolytic uremic syndrome in different geographic regions. These findings may provide new opportunities for the design of therapeutic and preventive strategies in this disorder.
On-road charging of electric vehicles (2013)

Contactless Power Transfer (CPT) systems are applicable for charging electric vehicles (EVs) without any physical interconnection. These systems can be installed on roadways in order to charge the vehicles while driving. The implementation of such on-road charging systems in order to extend the driving range and decrease the EV battery size is investigated in this paper. The percentage of road that should be covered and the power transfer capability of the system are estimated. Some design considerations, such as the distribution and the length of the CPT segments over the road, are explained. Finally, the total power demand for all the passing-by vehicles using the system is calculated and the possibility of powering the EVs directly from renewable energy sources is discussed.
Solving systems of set constraints with negated subset relationships (2002)

We present a decision procedure, based on tree automata techniques, for satisfiability of systems of set constraints including negated subset relationships. This result extends all previous works on set constraints solving and solves a problem which was left open by L. Bachmair et al. (1993). We prove in a constructive way that a non empty set of solutions always contains a regular solution, that is a tuple of regular tree languages. Moreover, we think that the new class of tree automata described here could be interesting in its own.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Gastrointestinal Complications of Laparoscopic Roux-en-Y Gastric Bypass Surgery: Clinical and Imaging Findings (2002)

Upper GI complications that required intervention occurred in 9.5% of patients. CT and upper GI series can depict most major complications.
Col4a1 mutation causes endoplasmic reticulum stress and genetically modifiable ocular dysgenesis (2007)

Ocular anterior segment dysgenesis (ASD) is a complex and poorly understood group of conditions. A large proportion of individuals with ASD develop glaucoma, a leading cause of blindness resulting from retinal ganglion cell death. Optic nerve hypoplasia is thought to have distinct causes and is a leading cause of blindness in children. Here, we show that a mutation in the type IV collagen alpha 1 (Col4a1) gene can cause both ASD and optic nerve hypoplasia. COL4A1 is a major component of almost all basement membranes. The mutation results in non-secretion of the mutant COL4A1 proteins, which instead accumulate within cells. Basement membrane abnormalities may, therefore, contribute to the phenotype. The mutation also induces endoplasmic reticulum stress and so intracellular stress may contribute to pathogenesis. The overall consequence of the Col4a1 mutation depends on genetic context. In one genetic context, the mutation causes severe ASD with intraocular pressure abnormalities and optic nerve hypoplasia. In a different genetic context, both the ASD and optic nerve hypoplasia are rescued, and we have identified a single dominant locus that confers the phenotypic modification.
Design of regular (2,d/sub c/)-LDPC codes over GF(q) using their binary images (2008)

In this paper, a method to design regular (2, d <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> )- LDPC codes over GF(q) with both good waterfall and error floor properties is presented, based on the algebraic properties of their binary image. First, the algebraic properties of rows of the parity check matrix H associated with a code are characterized and optimized to improve the waterfall. Then the algebraic properties of cycles and stopping sets associated with the underlying Tanner graph are studied and linked to the global binary minimum distance of the code. Finally, simulations are presented to illustrate the excellent performance of the designed codes.
Spatial Learning and Localization in Animals: A Computational Model and Behavioral Experiments (1998)

This paper describes a computational model of spatial learning and localization. The model is based on the suggestion (based on a large body of experimental data) that rodents learn metric spatial representations of their environments by associating sensory inputs with dead-reckoning based position estimates in the hippocampal place cells. Both these sources of information have some uncertainty associated with them because of errors in sensing, range estimation, and path integration. The proposed model incorporates explicit mechanisms for information fusion from uncertain sources. We demonstrate that the proposed model adequately reproduces several key results of behavioral experiments with animals. Keywords: cognitive modeling, cognitive maps, Hippocampus, probabilistic localization. INTRODUCTION Animals display a wide range of complex spatial learning and navigation abilities (Schone, 1984; Gallistel, 1990), far more impressive than the capabilities of contemporary robots. Consider...
Local structure of Pt and Pd ions in Ce1−xTixO2: X-ray diffraction, x-ray photoelectron spectroscopy, and extended x-ray absorption fine structure (2008)

Ce(1-x-y)Ti(x)Pt(y)O(2-delta) (x=0.15; y=0.01) and Ce(1-x-y)Ti(x)Pd(y)O(2-delta) (x=0.25; y=0.02 and 0.05) are found to be good CO oxidation catalysts [T. Baidya et al., J. Phys. Chem. B 110, 5262 (2006); T. Baidya et al., J. Phys. Chem. C 111, 830 (2007)]. A detailed structural study of these compounds has been carried out by extended x-ray absorption fine structure along with x-ray diffraction and x-ray photoelectron spectroscopy. The gross cubic fluorite structure of CeO(2) is retained in the mixed oxides. Oxide ion sublattice around Ti as well as Pt and Pd ions is destabilized in the solid solution. Instead of ideal eight coordinations, Ti, Pd, and Pt ions have 4+3, 4+3, and 3+4 coordinations creating long and short bonds. The long Ti-O, Pd-O, and Pt-O bonds are approximately 2.47 A (2.63 A for Pt-O) which are much higher than average Ce-O bonds of 2.34 A.
Teaming Up to Clarify Communications (2004)

This article describes how the Las Virgenes (California) Municipal Water District (LVMWD) redesigned its structure in order to achieve greater clarity and consistency in customer‐related communications. Going from an organizational structure based on bureaucratic “silos” that separated field and office functions relating to customers, LVMWD decided to combine Public Outreach, Office Customer Service, Billing, Meter Reading, and Field Customer Service into a single department. LVMWD used the method of looking at itself through the eyes of the customer to determine how to reorganize to achieve the greatest efficiency for its customers.
[3H]inositol incorporation into phosphatidyl-inositol in work-induced growth of rat muscle. (1977)

Unilateral tenotomy of the gastrocnemius muscle in normal rats caused rapid hyptertrophy of the soleus and plantaris muscles. The phospholipid content of hypertrophied muscles increased; the increase was proportional to the extent of hypertrophy and was distributed proportionally among the major phospholipid components. During the growth process, the hypertrophying muscles incorporated [3H]inositol into phosphatidyl-inositol more rapidly than did the contralateral, control limb muscles. The increased incorporation was evident 2 h after the operation and cannot be explained solely by an increased uptake of [3H]inositol. After growth had ceased, the incorporation of [3H]inositol into phosphatidyl-inositol gradually returned toward control levels. The increase in incorporation after tenotomy was prevented by simultaneous spinal section to abolish activity in the tenotomized limb muscles. By contrast, in rats that had been forced to swim for prolonged periods of time, there was no increased incorporation of [3H]inositol into phosphatidyl-inositol. It is concluded that the increased incorporation of [3H]inositol into phosphatidyl-inositol is related to increased muscle activity sufficient to produce compensatory hypertrophy.