gebhart/patrepeval huggingface dataset:
[Molecular-genetic characteristics of Mycobacterium tuberculosis strains isolated from patients with tuberculous spondylitis]. (2014)

Molecular-genetic characteristic of M. tuberculosis strains isolated from operation material of patients with tuberculous spondylitis.107 strains of M. tuberculosis isolated in 2007 - 2011 from patients with spine tuberculosis were studied by methods of spoligotyping and MIRU-VNTR by 12 and 24 loci.Strains of genetic family Beijing dominated (n = 80), 78% of those had multiple drug resistance (MDR). Strains of genetic families T, H3 (Ural), LAM, Manu, H4 and S were also detected. Differentiating of 80 strains of Beijing genotype by MIRU-VNTR method by 24 loci revealed 24 variants (HGI = 0.83) including 7 clusters, the largest of those (100-32) included 23 strains (87% MDR).The leading role of Beijing genotype M. tuberculosis strains in development of tuberculous spondylitis with multiple drug resistance of the causative agent is shown.
Incidence of abnormalities of the kidney and ureter in congenital scoliosis. (1974)

The frequent occurrence of urinary tract anomalies which have been observed in patients with congenital scoliosis at the Alfred I. duPont Institute led us to evaluate this group to determine its incidence. We found that 13% of the patients with congenital scoliosis had renal abnormalities of varying types-lesions which may predispose to urinary tract pathology--but only one had any symptoms suggesting urinary tract disease.
Shadow Inspection of 3D Objects in Partially Coherent Light (2011)

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Costs associated with delirium in mechanically ventilated patients* (2004)

Delirium is a common clinical event in mechanically ventilated medical intensive care unit patients and is associated with significantly higher intensive care unit and hospital costs. Future efforts to prevent or treat intensive care unit delirium have the potential to improve patient outcomes and reduce costs of care.
RelB/p50 Complexes Regulate Cytokine-Induced YKL-40 Expression (2015)

The secreted protein, YKL-40, has been proposed as a biomarker of a variety of human diseases characterized by ongoing inflammation, including chronic neurologic pathologies such as multiple sclerosis and Alzheimer's disease. However, inflammatory mediators and the molecular mechanism responsible for enhanced expression of YKL-40 remained elusive. Using several mouse models of inflammation, we now show that YKL-40 expression correlated with increased expression of both IL-1 and IL-6. Furthermore, IL-1 together with IL-6 or the IL-6 family cytokine, oncostatin M, synergistically upregulated YKL-40 expression in both primary human and mouse astrocytes in vitro. The robust cytokine-driven expression of YKL-40 in astrocytes required both STAT3 and NF-κB binding elements of the YKL-40 promoter. In addition, YKL-40 expression was enhanced by constitutively active STAT3 and inhibited by dominant-negative IκBα. Surprisingly, cytokine-driven expression of YKL-40 in astrocytes was independent of the p65 subunit of NF-κB and instead required subunits RelB and p50. Mechanistically, we show that IL-1-induced RelB/p50 complex formation was further promoted by oncostatin M and that these complexes directly bound to the YKL-40 promoter. Moreover, we found that expression of RelB was strongly upregulated during inflammation in vivo and by IL-1 in astrocytes in vitro. We propose that IL-1 and the IL-6 family of cytokines regulate YKL-40 expression during sterile inflammation via both STAT3 and RelB/p50 complexes. These results suggest that IL-1 may regulate the expression of specific anti-inflammatory genes in nonlymphoid tissues via the canonical activation of the RelB/p50 complexes.
Interactions between the interface of titanium and fullerene (1996)

X-ray diffraction, photoemission, and Auger electron spectroscopy studies are reported of the interactions between the interface of titanium and C60 solid film during low-temperature annealing. The structure of C60 at the Ti/C60 interface is disrupted by the Ti atoms when Ti is deposited onto the surface of C60 film. Titanium atoms react with carbon atoms to form amorphous Ti carbide during low-temperature annealing. This interaction is related to the solid state amorphization reaction of the deposited Ti layer with C60 film, which occurs with a driving force of a negative heat of formation in the Ti–C system and a dominant diffusion of carbon into the Ti overlayer.
Understanding Dealumination Mechanisms in Protonic and Cationic Zeolites (2019)

Zeolites can be partially hydrolyzed by steam via Al extraction which leads to the formation of a moiety with four hydroxyl groups. This irreversible dealumination process can decrease the crystallinity of zeolites and effectively modify their acidity, porosity, and catalytic activity. This paper addresses the hydrolysis mechanism of the first Al–O bond in protonic (H+) and cationic (M = Na+, K+, and Ca2+) LTA zeolites. Periodic density functional theory calculations demonstrate that cationic LTA zeolites are more kinetically stable than H-LTA by exhibiting higher reaction barriers. Analysis revealed a H2O dissociation reaction mechanism involving proton transfers and rotations in both protonic and cationic zeolites, which further leads to the Al–O bond breaking. Our results also indicate that a lower Si/Al ratio tends to favor hydrolysis reactions, while the cation identity has a small effect on the reaction barriers. A correlation between the Al–O bond length in the initial adsorbed states and the reaction activation energies is identified.
A microcomputer based system for automated pattern digitization and editing (1978)

Since the first microcomputer was produced in 1969 by Intel Corporation to support the functions of an intelligent terminal, the complexion of digital computers has changed radically. Microcomputers have been successfully applied to a wide variety of dedicated tasks requiring relatively slow calculation speeds and limited numeric accuracy.
Molecular Mechanisms of the Biphasic Effects of Interferon-γ on Osteoclastogenesis (2011)

Although interferon-γ (IFN-γ) potently inhibits osteoclastogenesis, the suppressive effect is significantly reduced when osteoclast precursors are pre-exposed to the receptor activator of NF-κB (RANK) ligand (RANKL). However, the molecular mechanism underlying the biphasic effects of IFN-γ on osteoclastogenesis remains elusive. Here, we recapitulate the biphasic functions of IFN-γ in osteoclastogenesis in both tissue culture dishes and on bone slices. We further demonstrate that IFN-γ markedly suppresses the RANKL-induced expression of nuclear factor of activated T-cells c1 (NFATc1) in normal, but not RANKL-pretreated bone marrow macrophages (BMMs). Similarly, IFN-γ impairs the activation of the nuclear factor-κB (NF-κB) and c-Jun N-terminal kinase (JNK) pathways in normal, but not RANKL-pretreated, BMMs. These findings indicate that IFN-γ inhibits osteoclastogenesis partially by suppressing the expression of NFATc1 and the activation of the NF-κB and JNK pathways. Moreover, IFN-γ inhibits the RANKL-induced expression of osteoclast genes, but RANKL pretreatment reprograms osteoclast genes into a state in which they can no longer be suppressed by IFN-γ, indicating that IFN-γ inhibits osteoclastogenesis by blocking the expression of osteoclast genes. Finally, the IVVY(535-538) motif in the cytoplasmic domain of RANK is responsible for rendering BMMs refractory to the inhibitory effect of IFN-γ. Taken together, these findings provide important mechanistic insights into the biphasic effects of IFN-γ on osteoclastogenesis.
Optimizing Pumped Insulin Delivery (1982)

The use of portable devices for the subcutaneous infusion of insulin may facilitate the attainment of improved glycemic control in selected patients with insulin-dependent diabetes mellitus. Successful use of a program of continuous subcutaneous insulin infusion requires patient cooperation and motivation, routine monitoring of glycemia, and attention to food intake and activity. This article describes an approach by which patients may optimize glycemic control utilizing a set of algorithms based on patientdetermined blood glucose measurements. The algorithms permit programing the insulin infusion device to achieve the desired control.
In Situ Detection of Protein Complexes and Modifications by Chemical Ligation Proximity Assay (2016)

Protein function is often regulated by protein-protein interactions and post-translational modifications. Detection of these important biological phenomena in fixed biological samples could serve as an invaluable tool in biomedical research, drug development, as well as clinical cancer diagnostics and prognostics. We report here a novel methodology which utilizes unique antibody bioconjugates capable of forming proximity induced chemical ligation to enable in situ detection of proximal targets in fixed biological samples. Using this new methodology, we demonstrate in situ visualization of various protein heterodimers/complexes and post-translational modifications such as phosphorylation and ubiquitination. This new method offers high specificity, sensitivity, flexibility, and ease of use. In addition, the assay preserves critical contextual and heterogeneity information on biomarkers in clinically relevant samples.
Initiation of acetylene polymerization by metal carbenes (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInitiation of acetylene polymerization by metal carbenesThomas J. Katz and Steven J. LeeCite this: J. Am. Chem. Soc. 1980, 102, 1, 422–424Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/ja00521a094https://doi.org/10.1021/ja00521a094research-articleACS PublicationsRequest reuse permissionsArticle Views632Altmetric-Citations234LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Synthesis of Silicon Carbide–Silicon Nitride Composite Ultrafine Particles Using a Carbon Dioxide Laser (1993)

The synthesis and the structure of silicon carbide‐silicon nitride (SiC─Si 3 N 4 ) composite ultrafine particles have been studied. SiC─Si 3 N 4 composite ultrafine particles were prepared by irradiating a SiH 4 , C 2 H 4 , and NH 3 gas mixture with a CO 2 laser at atmospheric pressure. The composition of composite powders changed with the reactant gas flow rate. The carbon and nitrogen content of the powder could be controlled in a wide range from 0 to 30 wt%. The composite powder, which contained 25.3 wt%. carbon and 5.8 wt% nitrogen, had a (β‐SiC structure. As the nitrogen con‐ tent increased, SiC decreased and amorphous phase, Si 3 N 4 , Si appeared. The results of XPS and lattice constant measurements suggested that Si, C, and N atoms were intimately mixed in the composite particles.
Vehicle Classification Based on the Radar Measurement of Height Profiles (2007)

The problem of classifying road vehicles according to vehicle type is considered. The proposed solution is based on using vehicle height and length and height profiles obtained by a microwave (MW) radar sensor. We show that if the radar sensor satisfies certain requirements, then a precise feature vector can be extracted, and simple deterministic algorithms can be applied to determine the vehicle class. Field trials using a spread-spectrum MW radar sensor system operating on these principles have been carried out. They confirm that accurate classification of a large number of vehicle classes can be reached
Nonlinear flow phenomena in a symmetric sudden expansion (1990)

The origin of steady asymmetric flows in a symmetric sudden expansion is studied using experimental and numerical techniques. We show that the asymmetry arises at a symmetry-breaking bifurcation and good agreement between the experiments and numerical calculations is obtained. At higher Reynolds numbers the flow becomes time-dependent and there is experimental evidence that this is associated with three-dimensional effects.
An FPGA implementation of a brushless DC motor speed controller (2010)

The spreading of brushless DC (BLDC) motors has imposed the need for efficient and low cost motor control drives. In this paper, a low cost digital controller is presented. For experimental testing, the controller is implemented inside a field programmable gate array (FPGA) device. The developed design is validated in a modular fashion by logic simulation and experimental results are provided. The main contribution is the presented controller design methodology for FPGA implementation.
The Etiology of Syncope in Patients With Negative Tilt Table and Electrophysiological Testing (1995)

Unexplained syncope in patients with negative investigations has a broad spectrum of etiologies, the most common of which is bradycardia. An implantable long-term monitoring device is useful for establishing a diagnosis when symptoms are recurrent but too infrequent for conventional monitoring techniques.
Aptamer and Antisense-Mediated Two-Dimensional Isolation of Specific Cancer Cell Subpopulations (2016)

Cancer cells, and in particular those found circulating in blood, can have widely varying phenotypes and molecular profiles despite a common origin. New methods are needed that can deconvolute the heterogeneity of cancer cells and sort small numbers of cells to aid in the characterization of cancer cell subpopulations. Here, we describe a new molecular approach to capturing cancer cells that isolates subpopulations using two-dimensional sorting. Using aptamer-mediated capture and antisense-triggered release, the new strategy sorts cells according to levels of two different markers and thereby separates them into their corresponding subpopulations. Using a phenotypic assay, we demonstrate that the subpopulations isolated have markedly different properties. This system provides an important new tool for identifying circulating tumor cell subtypes.
Adverse Work and Environmental Conditions Predict Occupational Injuries: The Israeli Cardiovascular Occupational Risk Factors Determination in Israel (CORDIS) Study (1999)

This study was designed to test whether the total objective adverse work and environmental conditions, expressed as the ergonomic stress level (ESL), would predict occupational injuries over a 2-year period. The study population consisted of 4,096 men from 21 factories in six industrial sectors who were studied as part of the Israeli Cardiovascular Occupational Risk Factors Determination in Israel (CORDIS) Study, 1985-1987. The ESL (assigned four levels, 1-4) was based on an ergonomic assessment which covered 17 risk factors pertaining to safety hazards, overcrowding, cognitive and physical demands, and environmental stressors. The ESL was found to be a highly reliable measure and stable over a period of 2-4 years. The incidence of injuries among workers in low ESL conditions (level 1) was 10.3%. It increased with higher ESL's: 11.7% in level 2 (relative risk (RR) = 1.13, 95% confidence interval (CI) 0.86-1.50); 21.6% in level 3 (RR = 2.09, 95% CI 1.68-2.62); and 23.8% in level 4 (RR = 2.31, 95% CI 1.85-2.88). After adjustment for age, job experience, educational level, managerial status, and occupational status (white/blue collar), injury occurrence was significantly elevated for those at level 3 (adjusted odds ratio (OR) = 1.46, 95% CI 1.12-1.91) and level 4 (adjusted OR = 1.81, 95% CI 1.39-2.37) but not for level 2 (adjusted OR = 0.87, 95% CI 0.65-1.18). The authors conclude that adverse work and environmental conditions, objectively assessed, can predict occurrence of occupational injuries.
Prediction of Lobar Collateral Ventilation in 25 Patients With Severe Emphysema by Fissure Analysis With CT (2013)

Reducing pulmonary volume through implantation of endobronchial valves is a major interest to improve exercise tolerance and survival in patients with severe emphysema. The primary aim of this study was to evaluate how well CT-determined fissure integrity predicts interlobar collateral ventilation. The secondary objective was to show whether there is a relationship between the size of fissural defects and the presence of collateral ventilation.Thirty patients with heterogeneous emphysema (postbronchodilator forced expiratory volume in 1 second [FEV1] = 20-50% predicted and > 50% of emphysema in a lobe) underwent collateral ventilation measurements with a catheter through an occlusive balloon within this target lobe during flexible endoscopy. Two senior thoracic radiologists studied the fissures on thoracic high-resolution CT.Collateral ventilation was successfully measured in 37 target lobes in 25 patients. The fissures surrounding the 37 target lobes were evaluated on CT. For the detection of collateral ventilation, the presence of a fissural defect on CT has a sensitivity, specificity, positive predictive value, and negative predictive value of 95%, 44%, 69%, and 88%, respectively. There was a statistically significant difference in the area of the defect between patients with collateral ventilation and those without collateral ventilation (p = 0.04).Analysis of pulmonary fissures using CT is useful before endoscopic volume reduction because results are well correlated to endoscopic measurements of collateral ventilation. Further study with clinical outcomes is mandatory to determine if and when one test or the other or both should be used in patient selection.
Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells. (1992)

The formation and persistence of O6-ethylguanine, O4-ethylthymine, and O2-ethylthymine were quantitated in the genomic DNA of human lymphoblasts exposed to 1.0 mM N-ethyl-N-nitrosourea using immunoslot-blot. The three cell lines used included one which lacks O6-alkylguanine-DNA alkyltransferase, one deficient in nucleotide excision repair, and a third which is competent in both of these repair pathways. The activity of O6-alkylguanine-DNA alkyltransferase was further modulated with O6-benzylguanine, a specific inhibitor of this protein. Repair of the O-ethylated thymines was slow and not related to either DNA repair phenotype. O6-Ethylguanine was repaired with a half-life of about 8 h in cells which expressed both O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair functions. Cells expressing O6-alkylguanine-DNA alkyltransferase activity but lacking nucleotide excision repair showed only slow repair of O6-ethylguanine (half-life of O6-ethylguanine, 43 h), while cells lacking the alkyltransferase showed little or no repair of O6-ethylguanine regardless of nucleotide excision repair activity (half-lives of O6-ethylguanine, 53 to greater than 100 h). We conclude that O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair cooperate in the repair of O6-ethylguanine in human cells.
A modular approach for high Q microwave CMOS active inductor design (2002)

In this paper, a modular approach for the L-band CMOS Active Inductor (AI) is proposed and designed based upon a connection in series of conventional low Q-factor gyrator-C basic cells. The Q-factor can then be tuned by the number of AI cells in order to offer simplicity in terms of pole/zero cancellation, while maintaining in each gyrator-C inductor cell low values of Q. In order to demonstrate the proposed architecture's usefulness, a prototype L-band active inductor is designed in a 0.6 /spl mu/m CMOS process. The simulated results show that a high Q value of 972 is obtained at 2 GHz and an average Q-factor value of 200 is also achieved in the frequency range of 1-2 GHz.
Operative Procedure and Results of Expansive Open-Door Laminoplasty (1988)

From the Department of Orthopaedic Surgery, School of Medicine, Keio Gijuku University Tokyo, Japan
Recent Advances in the Development of Semiconducting DPP‐Containing Polymers for Transistor Applications (2012)

This progress report summarizes the numerous DPP-containing polymers recently developed for field-effect transistor applications including diphenyl-DPP and dithienyl-DPP-based polymers as the most commonly reported materials, but also difuranyl-DPP, diselenophenyl-DPP and dithienothienyl-DPP-containing polymers. We discuss the hole and electron mobilities that were reported in relation to structural properties such as alkyl substitution patterns, polymer molecular weights and solid state packing, as well as electronic properties including HOMO and LUMO energy levels. We moreover consider important aspects of ambipolar charge transport and highlight fundamental structure-property relations such as the relationships between the thin film morphologies and the charge carrier mobilities observed for DPP-containing polymers.
Measuring Semantic Similarity in Wordnet (2007)

Semantic similarity between words is a generic problem for many applications of computational linguistics and artificial intelligence. The difficulty of this task lies in how to find an effective way to simulate the process of human judgment of word similarity by combining and processing a number of information sources. This paper presents a novel model to measure semantic similarity between words in the WordNet, using edge-counting techniques. The fundamental idea of this model is based on the assumption that human judgment process for semantic similarity can be simulated by the ratio of common features to the total features between words. According to the experiment against a benchmark set by human similarity judgment, our measure achieves a better result. The correlation is 0.926 with average human judgment on a standard 28 word-pair dataset, which outperforms other previous reported methods.
Low-noise CMOS integrated sensing electronics for capacitive MEMS strain sensors (2004)

This paper describes a high-performance strain sensing microsystem. A MEMS capacitive strain sensor converts an input strain to a capacitance change with a sensitivity of 26.5 aF per 0.1 /spl mu//spl epsiv/. Low-noise integrated sensing electronics, employing a continuous time synchronous detection architecture, convert the capacitive signal to an output voltage for further signal processing. The prototype microsystem achieves a minimum detectable strain of 0.09 /spl mu//spl epsiv/ over a 10 kHz bandwidth with a dynamic range of 81 dB. The sensing electronics consume 1.5 mA from a 3 V supply.
Network Design and Architectures for Highly Dynamic Next-Generation IP-over-Optical Long Distance Networks (2009)

We present initial network architectures and capacity-efficient design for an IP/Optical network with highly dynamic IP and wavelength services, restoration against up to 3 failures, and aggregate traffic levels that represent a 10-fold increase over today’s network traffic.