gebhart/patrepeval huggingface dataset:
Efficient Neural Network Compression (2018)

Network compression reduces the computational complexity and memory consumption of deep neural networks by reducing the number of parameters. In SVD-based network compression, the right rank needs to be decided for every layer of the network. In this paper, we propose an efficient method for obtaining the rank configuration of the whole network. Unlike previous methods which consider each layer separately, our method considers the whole network to choose the right rank configuration. We propose novel accuracy metrics to represent the accuracy and complexity relationship for a given neural network. We use these metrics in a non-iterative fashion to obtain the right rank configuration which satisfies the constraints on FLOPs and memory while maintaining sufficient accuracy. Experiments show that our method provides better compromise between accuracy and computational complexity/memory consumption while performing compression at much higher speed. For VGG-16 our network can reduce the FLOPs by 25% and improve accuracy by 0.7% compared to the baseline, while requiring only 3 minutes on a CPU to search for the right rank configuration. Previously, similar results were achieved in 4 hours with 8 GPUs. The proposed method can be used for lossless compression of a neural network as well. The better accuracy and complexity compromise, as well as the extremely fast speed of our method makes it suitable for neural network compression.
ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis (2015)

The ORM1 (Saccharomyces cerevisiae)-like proteins (ORMDLs) and their yeast orthologs, the Orms, are negative homeostatic regulators of the initiating enzyme in sphingolipid biosynthesis, serine palmitoyltransferase (SPT). Genome-wide association studies have established a strong correlation between elevated expression of the endoplasmic reticulum protein ORMDL3 and risk for childhood asthma. Here we test the notion that elevated levels of ORMDL3 decrease sphingolipid biosynthesis. This was tested in cultured human bronchial epithelial cells (HBECs) (an immortalized, but untransformed, airway epithelial cell line) and in HeLa cells (a cervical adenocarcinoma cell line). Surprisingly, elevated ORMDL3 expression did not suppress de novo biosynthesis of sphingolipids. We determined that ORMDL is expressed in functional excess relative to SPT at normal levels of expression. ORMDLs and SPT form stable complexes that are not increased by elevated ORMDL3 expression. Although sphingolipid biosynthesis was not decreased by elevated ORMDL3 expression, the steady state mass levels of all major sphingolipids were marginally decreased by low level ORMDL3 over-expression in HBECs. These data indicate that the contribution of ORMDL3 to asthma risk may involve changes in sphingolipid metabolism, but that the connection is complex.
Crystal Growth of the Perovskite Semiconductor CsPbBr<sub>3</sub>: A New Material for High-Energy Radiation Detection (2013)

The synthesis, crystal growth, and structural and optoelectronic characterization has been carried out for the perovskite compound CsPbBr3. This compound is a direct band gap semiconductor which meets most of the requirements for successful detection of X- and γ-ray radiation, such as high attenuation, high resistivity, and significant photoconductivity response, with detector resolution comparable to that of commercial, state-of-the-art materials. A structural phase transition which occurs during crystal growth at higher temperature does not seem to affect its crystal quality. Its μτ product for both hole and electron carriers is approximately equal. The μτ product for electrons is comparable to cadmium zinc telluride (CZT) and that for holes is 10 times higher than CZT.
La creación de exponentes continuos: un estudio sobre los métodos y la epistemología de John Wallis (2000)

El siguiente es un trabajo de investigación histórica que se enfoca en momentos matemáticos específicos donde los métodos, conceptos y definiciones experimentaron profundos cambios. Hay dos metas principales. Primero, bosquejar la historia del desarrollo de un concepto de exponentes continuos y segundo, examinar cuidadosamente el escenario epistemológico en el que este desarrollo se llevo a cabo. Puesto de manera más simple, qué fue lo que convenció a ciertos matemáticos de que sus conceptos eran viables. No pretende ser una discusión histórica completa, sino más bien una serie de instantáneas. Los detalles matemáticos de estos momentos se dan en la medida en que sean necesarios para entender la epistemología.
A Pipeline-Based Scheduler for Optimizing Latency of Convolution Neural Network Inference over Heterogeneous Multicore Systems (2020)

Parallelization is a common design practice for throughput improvement on multicore systems. However, the existing operating systems' schedulers for CNN inference essentially divide the computational tasks of each convolution layer onto different CPU cores and cause significant inter-core feature-map data movement. Therefore, the overall performance is often degraded. In this paper, we propose a pipeline-based scheduler for convolution neural network inference parallelization with minimal feature-map data movement requirements. The experimental results show that our approach can achieve 73% performance improvement on throughput compared to the existing multi-thread scheduler.
The role of kallikreins in inflammatory skin disorders and their potential as therapeutic targets (2020)

The skin is a vital organ of the human body, serving numerous protective and functional roles that are essential for survival. Residing in the epidermis are various epidermal proteases responsible for the establishment and regulation of barrier function. The human tissue kallikrein-related peptidase family conserves homeostasis of the skin barrier through their roles in desquamation, antimicrobial defense, innate immune response, and barrier maintenance. The activity of kallikreins is tightly regulated and dysregulation of kallikrein activity is seen to contribute to the formation of several inflammatory skin disorders. This review highlights the roles of kallikreins in skin homeostasis and pathologies. Due to their part in these skin disorders, inhibitors of the skin kallikreins have become attractive therapeutics. Over the past few years, both natural and synthetic inhibitors of several kallikreins have been identified and are undergoing further development as treatments to restore compromised barrier function. This review summarizes the kallikrein inhibitors under development for this purpose. These inhibitors remain promising therapeutics in cases of severe skin inflammation not well managed by current therapies.
341. Investigations in the diphenylene oxide series. Part III (1932)

N. M. Cullinane, J. Chem. Soc., 1932, 2365 DOI: 10.1039/JR9320002365
The effects of phosphatidic acid supplementation on strength, body composition, muscular endurance, power, agility, and vertical jump in resistance trained men (2016)

The results of this eight week trial suggest that the addition of MaxxTOR® to a 3-day per week resistance training program can positively impact LBM and strength beyond the results found with exercise alone.
Astrocytic Swelling Due to Hypotonic or High K<sup>+</sup> Medium Causes Inhibition of Glutamate and Aspartate Uptake and Increases Their Release (1995)

Astrocytic swelling occurs readily in ischemia and traumatic brain injury (TBI) as part of the cytotoxic or cellular edema response. Ischemia is known to produce large extracellular increases in both [K+] and excitatory amino acids (EAA) in vivo, and astrocytic swelling in vitro leads to marked release of EAA. In this study we compared the effect of swelling due to hypotonic media and high K+ medium on the uptake and release of EAA by rat primary astrocyte cultures in vitro. In both cases, there was a significant inhibition of uptake of [3H]L-glutamate and [3H]D-aspartate, and increased release of preloaded [3H]D-aspartate. The kinetics of the increased efflux was very different in response to hypotonic or high K+ media. In hypotonic medium there was a rapid initial release followed by a decline in the rate of release over time. This release was independent of whether Na+ was present. Upon exposure to high K+ medium there was a slow progressive increase in release of [3H]D-aspartate, which never showed any subsequent decline until the media was returned to normal [K+]. In high K+ media there was also an initial transient increase in [3H]D-aspartate release, which we attribute to reversal of the amino acid uptake system. The increased release due to hypotonic medium was not affected by a drop in temperature from 37 to 26 degrees C, while the increased release due to high K+ medium was completely inhibited.(ABSTRACT TRUNCATED AT 250 WORDS)
Identifying discriminatory information content within the iris (2008)

The iris contains fibrous structures of various sizes and orientations which can be used for human identification. Drawing from a directional energy iris identification technique, this paper investigates the size, orientation, and location of the iris structures that hold stable discriminatory information. Template height, template width, filter size, and the number of filter orientations were investigated for their individual and combined impact on identification accuracy. Further, the iris was segmented into annuli and radial sectors to determine in which portions of the iris the best discriminatory information is found. Over 2 billion template comparisons were performed to produce this analysis.
Data Management and applications at SOCIB (2013)

Trabajo presentado en la International Conference on Marine Data and Information Systems, celebrado en Lucca, Italia, del 23 al 25 de septiembre de 2013
Contacts between Escherichia coli RNA polymerase and a lac operon promoter. (1978)

The chemical alkylating agent dimethyl sulfate can probe the interaction between Escherichia coli RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) and the purine bases of a promoter. This agent methylates the N7 position on guanine or the N3 position on adenine; the bound protein can either protect these positions or affect the reactivity to produce an enhanced methylation. The pattern of DNA residues in the lactose promoter protected from, or enhanced to, methylation by a specifically bound polymerase shows that the enzyme covers a region of at least 38 base pairs, stretching upstream from the origin of transcription. These protein-DNA contacts occur predominantly in the major groove of the DNA helix. Furthermore, this pattern of methylation shows that the polymerase unwinds the helix at the origin of transcription. The relationship between polymerase-DNA contacts defined by dimethyl sulfate and known features of promoter structure is discussed. To facilitate these experiments I have constructed a plasmid that permits a unique 5'-end labeling of each strand of a 95-base-pair fragment containing a lac operon promoter. This plasmid contains two copies of the lac promoter-operator region.
Iturin AL - A new long chain iturin a possessing an unusual high content of C16-.BETA.-amino acids. (1983)

From a strain of Bacillus subtilis a new antifungal peptidolipid complex of the iturin group was isolated. This antibiotic complex contained six lipophilic beta-amino acids with 3-amino-14-methylpentanoic acid as the predominant component. Iturin AL contains: 2 D-Asp, 1 L-Asp, 1 L-Glu, 1 L-Pro, 1 L-Ser, 1 D-Tyr and a mixture of 2.9% iso-C14-beta-amino acid, 30.7% n-C14-beta-amino acid, 15% iso-C15-beta-amino acid, 9% anteiso-C15-beta-amino acid, 35.3% iso-C-16-beta-amino acid and 4.5% n-C16-beta-amino acid. The structures of the beta-amino acids were determined by combined GLC/MS. FAB mass spectroscopy revealed three M+H+ peaks (1,043, 1,057, 1,071). Iturin AL could be resolved into six components by HPLC whose structures confirm the high amount of long chain beta-amino acids.
The long‐term survival of mice protected from 8MeV electron irradiation by combined treatment with cysteamine, hypoxia, syngeneic bone marrow and antibiotics (1966)

A number of blue-green algae and photosynthetic bacteria synthesize arginine from glutamate via acetylated intermediates. Cell-free extracts of these photosynthetic microorganisms contain an N-acetyl glutamate phosphokinase, which is specifically inhibited by arginine. They also contain a transacetylase which forms ornithine from aN-acetyl ornithine and glutamate. The transacetylase appears to be specific for L-glutamate. Arginine synthesis and its regulation by feedback inhibition in photosynthetic microorganisms differ from that in Escherichia coli and other Enterobacteriaceae.
SAMI: Service-based arbitrated multi-tier infrastructure for Mobile Cloud Computing (2012)

Mobile Cloud Computing (MCC) is the state-of-the-art mobile computing technology aims to alleviate resource poverty of mobile devices. Recently, several approaches and techniques have been proposed to augment mobile devices by leveraging cloud computing. However, long-WAN latency and trust are still two major issues in MCC that hinder its vision. In this paper, we analyze MCC and discuss its issues. We leverage Service Oriented Architecture (SOA) to propose an arbitrated multi-tier infrastructure model named SAMI for MCC. Our architecture consists of three major layers, namely SOA, arbitrator, and infrastructure. The main strength of this architecture is in its multi-tier infrastructure layer which leverages infrastructures from three main sources of Clouds, Mobile Network Operators (MNOs), and MNOs' authorized dealers. On top of the infrastructure layer, an arbitrator layer is designed to classify Services and allocate them the suitable resources based on several metrics such as resource requirement, latency and security. Utilizing SAMI facilitate development and deployment of service-based platform-neutral mobile applications.
Treatment of HBeAg-Positive Chronic Hepatitis with a Streptococcal Preparation (OK-432) (1985)

Forty-two patients with hepatitis Be antigen (HBeAg)-positive chronic hepatitis were treated by intramuscular injections with OK-432, an immunopotentiator possessing interferon-inducing activity. They were monitored with serial measurements of virological parameters to evaluate therapeutic effectiveness, and compared with a group of seventy-five untreated patients (natural course group). In the group receiving OK-432 therapy, twenty-seven patients (64.3% of the forty-two patients) became negative for HBeAg in an average observation period of 20.1 months. Of these, fourteen patients (33.3% of the forty-two patients) underwent seroconversion from HBeAg to anti-HBe antibody (anti-HBe). In the natural course group, twenty-three patients (30.7% of the seventy-five patients) lost HBeAg reactivity in a mean follow-up period of 32.3 months, and thirteen patients (17.3% of the seventy-five patients) became seroconverted. Thus, the drug group showed significantly higher percentages of patients with disappearance of HBeAg and seroconversion, notwithstanding the shorter duration of the follow-up. Young males and females, females generally, or patients with high serum GPT levels were more likely to respond to the therapy. The serum GPT level tended to stabilize more in patients receiving OK-432.
Expansion of CD133+ colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery (2010)

Our data suggest that ex vivo-expanded colon CSCs isolated from clinical specimens can be maintained in culture enabling the identification of CSC cell surface-associated proteins.
A New Digital Audio and Data Transmission System Using the CATV Network (1984)

CATV networks have great potential for high- speed data transmission owing to their excellent C/N and wide bandwidth. Their rapid proliferation makes them very attractive as data transmission media but there are still many problems in implementing the system-the incompatibility of much of the present CATV equipment and the interference of CATV services.
The synthetic retinoid fenretinide lowers plasma insulin-like growth factor I levels in breast cancer patients. (1993)

We studied the effect of fenretinide [N-(4-hydroxyphenyl)retinamide (4-HPR)], a synthetic analogue of retinoic acid, on plasma insulin-like growth factor I (IGF-I) levels in a consecutive cohort of stage I breast cancer patients belonging to a randomized phase III trial of breast cancer chemoprevention. Thirty-two women receiving 4-HPR 200 mg/daily and 28 untreated controls entered the study. IGF-I levels were determined after acid-ethanol extraction, on plasma obtained at randomization and after a mean time of 10.8 +/- 0.3 months. At baseline, there was no difference in IGF-I levels between the two groups [152.9 +/- 9.4 versus 159.2 +/- 7.0 ng/ml in treated and control group (P = 0.59), respectively]. After follow-up time, while plasma IGF-I levels were unchanged in control patients (163.3 +/- 7.4 ng/ml; P = 0.5), they were significantly reduced to 134.6 +/- 8.1 ng/ml in the patients treated with 4-HPR (P = 0.003 and P = 0.011 versus baseline and control values, respectively). Multiple regression analysis showed that treatment was the only determinant of IGF-I decline. Moreover, the interaction between treatment and age was significant, in that the decrease of IGF-I levels induced by 4-HPR administration was much more pronounced in younger patients, while an age-related decline was observed in controls. We conclude that the synthetic retinoid 4-HPR lowers circulating IGF-I levels in early breast cancer patients. Although the importance of this observation for the clinical prevention of breast cancer remains to be established, it further substantiates the rationale of the combination of 4-HPR with tamoxifen, which is known to decrease IGF-I as well and to act synergistically with the retinoid in preclinical models.
Design Scheme of Copyright Management System Based on Digital Watermarking and Blockchain (2018)

In the past, the improvement of digital copyright protection system based on digital watermarking mainly focused on algorithms, while generation and storage of the watermark information was ignored. In this paper, a new design scheme of copyright management system based on digital watermarking and its information, such as blockchain, is proposed, which combines digital watermarking, blockchain, perceptual hash function, Quick Response(QR) code, and InterPlanetary File System(IPFS). Among them, blockchain is used to securely store watermark information and provide timestamp authentication for multiple watermarks (multiple copyrights) to confirm the creation order. Perceptual hash function is used to generate hash value based on the structure information of images, that watermark information can be confirmed without the original image. QR code is used to generate QR code images containing image hash and copyright information as watermark images to improve robustness and capacity of digital watermarking; IPFS is used to store and distribute watermarked images without a centralized server. This scheme can enhance the effectiveness of digital watermarking technology in the field of copyright protection. In this way, use P2P network to integrate and complete copyright management and distribution of copyrighted works without requiring a trusted third party. Nodes rely on cryptography to confirm the identity of each other and ensure the security of information. It can reduce information leakage, data destruction and other risks caused by collapse of the centralized system in the past. This improves the security and transparency of information, and speeds up the distribution of copyrighted works to facilitate circulation in the network. This scheme can also improve copyright protection of multiple creations. Combine blockchain and multiple digital watermarks to record copyright information of every copyright owner in the authoring process and fully prove this information. In order to protect the legitimate rights and interests of each copyright owner.
Properties of a reconstituted vitamin D3 25-hydroxylase from rat liver mitochondria. (1980)

In a recent work we reported that a preparation of cytochrome P-450 from rat liver mitochondria was able to catalyze 25-hydroxylation of vitamin DI when combined with NADPH, adrenal ferredoxin, and ferredoxin reductase (Pedersen, J.-I., Holmberg, I., and Bjorkhem, I. (1979) FEBS Lett.98, 394).Optimal assay conditions have now been worked out for this conversion using a method based on isotope dilution-mass fragmentography.It was shown that a l l three components of the reconstituted system were required for the hydroxylation activity.The rate of conversion (about 0.02 nmol/nmol of cytochrome P-
Electronic-photonic integration in the helios project (2013)

Different ways of integrating of integrating photonics and electronics at the wafer level scale are reviewed: Monolithic, Back-Side, and Front-Side integration. Type and volume applications are selection criteria.
CEPM 4: comparison of simulation-driven construction operations visualization and 4D CAD (2002)

Several recent research efforts in visualizing construction are rooted in scheduling. They involve linking activity-based construction schedules and 3D CAD models of facilities to describe discretely-evolving construction product visualizations called 4D CAD. The focus is on communicating what component(s) are built where and when. The construction processes or operations actually involved in building them are usually implied. Ongoing research at Virginia Tech focuses on designing automated, simulation-driven methods to visualize, in addition to evolving construction products, the operations and processes that are performed in building them. In addition to what is built where and when, the effort is concerned with visualizing who builds it and how by depicting the interaction between involved machines, resources, and materials. This paper expounds the differences in concept, form, and content between 4D CAD and dynamic 3D visualization of operations simulations. An example of a structural steel framing operation is presented to elucidate the comparison.