gebhart/patrepeval huggingface dataset:
Host Resistance Mechanisms to Newcastle Disease Virus in Immunodeficient Chickens (1975)

In order to assess the mechanisms of host resistance to Newcastle disease virus (NDV), the susceptibility of young adult normal, T cell deficient and agammaglobulinemic chickens to an avirulent live vaccine (Bl) and a mesogenic strain of NDV was studied. All animals, regardless of immunological status resisted the vaccine strain. Most normal birds resisted mesogenic NDV, HOWEVER T cell deficient birds were much more susceptible and agammaglobulinemic chickens were extremely susceptible. There was no difference in the kinetics and levels of hemmagglutination-inhibition activity of plasma between normal, control-irradiated and T cell deficient birds nor between dying and surviving birds. Agammaglobulinemic chickens could be partially protected against an otherwise lethal challenge following immunization with avirulent NDV, low doses of mesogenic NDV inoculated intranasally or im injection of beta-propriolactone inactivated NDV mixed in complete Freund's adjuvant. The possible mechanisms for this protection together with the relative roles of humoral, cell mediated and non-specific immunity are discussed.
Gene Therapy for Hemophilia A (2022)

Hemophilia A is an X-linked bleeding disorder caused by defective coagulation Factor VIII (FVIII). Although the efficacies of existing treatment using purified or recombinant FVIII are good, there remain shortcomings in using this particular form of treatment. A few FVIII gene therapy clinical trials have been initiated with modest improvements recorded, but these are no longer being continued due to insufficient efficacy. However, with the progress in the development of gene delivery vectors and the availability of mouse and canine hemophilia A models, gene therapy of hemophilia A remains an area of hot pursuit.
Possible target components for the inhibitory effect of N‐ethylmaleimide on the activation of neutrophil NADPH oxidase (1998)

Potential target components for the inhibitory effect of covalent sulfhydryl-modifying reagent N-ethylmaleimide (NEM) on the activation of NADPH oxidase in human neutrophils was studied in a cell-free system. The capacity of both cytosol and membrane fractions to induce the translocation of cytosolic components and O2-generation in the cell-free activation system was affected by NEM. The phosphorylation of p47phox, which mediates the translocation of cytosolic complex, by protein kinase C was not inhibited by NEM and NEM-treated p47phox was as effective as untreated p47phox both in the kinase-dependent and in the amphiphile-dependent cell-free activation systems. In addition, phosphatidic acid-dependent phosphorylation of cytosol including p47phox was not affected by NEM. The inhibition of cytosol's capacity to activate NADPH oxidase was partially reversed by an addition of the fraction containing G-protein rac. Taken together, the data suggest that membrane component cytochrome b558 and cytosolic component rac may be the potential targets for the NEM effect on the activation of NADPH oxidase.
Microstructure and tribological performance of nanocomposite Ti–Si–C–N coatings deposited using hexamethyldisilazane precursor (2010)

Thick nanocomposite Ti–Si–C–N coatings (20–30 μm) were deposited on Ti–6Al–4V substrate by magnetron sputtering of Ti in a gas mixture of Ar, N2, and hexamethyldisilazane (HMDSN) under various deposition conditions. Microstructure and composition of the coatings were studied using scanning electron microscopy, x-ray diffraction, and energy dispersive x-ray spectroscopy, while the mechanical and tribological properties of these coatings were studied using Rc indentation, and micro- and nanoindentations, solid particle erosion testing, and ball-on-disk wear testing. It has been observed that the Si concentration of these coatings is varied from 0% (TiN) to 15% (Ti–Si–C–N), while the structure of these coatings is similar to the nanocomposite Ti–Si–N coatings and consists of nanocrystalline B1 structured Ti(C,N) in an amorphous matrix of SiCxNy with the grain size of 5−&gt;100 nm, depending on the coating preparation process. These coatings exhibit excellent adhesion when subjected to Rc indentation tests. The microhardness of these coatings varies from 1200 to 3400 HV25, while the nanohardness varies from 10 to 26 GPa. Both the microhardness and nanohardness are slightly lower than those of similar coatings prepared using trimethylsilane. However, the erosion test using a microsand erosion tester at both 30° and 90° incident angles shows that these coatings have very high erosion resistance and up to a few hundred times of improvement has been observed. These coatings also exhibit very high resistance to sliding wear with a low coefficient of friction of about 0.2 in dry sliding. There are a few advantages of using the HMDSN precursor to prepare the Ti–Si–C–N coatings over conventional magnetron sputtered deposition of Ti–Si–N coatings including composition uniformity, precursor handling safety, and high deposition rate. The coatings can be applied to protect gas turbine compressor blades from solid particle erosion and steam turbine blades from liquid droplet erosion, as well as other mechanical components that experience severe abrasion. These coatings may also be used in areas where both high wear resistance and low friction are required.
Hepatitis B Virus Antibody in Blood Donors and the Occurrence of Non-A, Non-B Hepatitis in Transfusion Recipients (1984)

Patients who received transfusions and nontransfused control patients were followed to assess the incidence and cause of post-transfusion hepatitis and to identify donor factors that might relate to risk of hepatitis. We evaluated as risk factors in donors the presence of antibody to hepatitis B virus compared with elevated alanine aminotransferase (ALT) level. Units of blood that were positive for antibody to hepatitis B core antigen (anti-HBc) were associated with a twofold to threefold greater risk of non-A, non-B hepatitis in the recipients than were units without anti-HBc. In the absence of specific serologic tests for non-A, non-B agents, screening of donors for anti-HBc might be considered. Our data suggest that the incidence of non-A, non-B hepatitis might have been reduced by about one third by such screening. However, elevated ALT levels in donors had a similar association with non-A, non-B hepatitis in recipients but would have resulted in fewer units of blood being discarded than would screening for anti-HBc.
Perception and production of /i:/, /i@/ and /e:/ in australian English (2008)

The progressive offglide reduction of / / and /e / or onglide reduction of /i / in Australian English is the major focus of this study. This paper examines, using synthetic speech tokens, the patterns of vowel perception of female and male speakers of Australian English in (approximately) 1990 and 2007. The relationship between production and perception in 2007 is also examined. This paper provides evidence that monophthongisation of /e / precedes that of / /. Females show a stronger pattern, than males, of offglide production for / / and /e / (in hV context) and onglide production for /i / (in hVd context). Females, but not males, show a significant negative correlation between /e / perception and production patterns. Females also show significantly stronger degrees of / / monophthong perception in hVd contexts than males, and there was evidence for a significant change in this pattern between 1990 and 2007.
Fourier-transform spectral imaging: retrieval of source information from three-dimensional spatial coherence (1986)

A method is described for efficiently obtaining the comprehensive information of a polychromatic radiator. Under certain conditions both the spatial and spectral details of the radiative object can be recovered simultaneously from the three-dimensional spatial coherence function in the diffraction region. The recovery of object information is based on a Fourier-transform relationship derived from the basic formula [ WolfE.CarterW. H., J. Opt. Soc. Am.68, 953– 964 ( 1978)] describing the field correlation function in terms of the source correlation function. A new type of interferometer is proposed for the efficient collection of the spatial coherence data. Experimental results of the spectral-image recovery are also presented.
“Click” methodologies: efficient, simple and greener routes to design dendrimers (2010)

Designing dendrimers that are monodisperse hyperbranched macromolecules and offer significant potential in numerous scientific fields, is becoming a major topical area in modern research. Among the challenges of the 21st century, synthetic methodologies that increase efficiency of conversion and a greener chemistry approach, are expected to lead the way in the quest to build novel nanomaterials. The recent entry of so-called "click" reactions that include Diels-Alder, Cu(I)-catalyzed Huisgen cycloaddition and thiol-ene coupling, have generated real stimulus not only in developing elegant materials of choice, but also in making the leap to industrial scale build-up of dendritic macromolecules. This tutorial review takes on the task of demonstrating the simplicity of these "click" reactions and the advantages they offer from a synthetic view point in developing mono- to multifunctional dendrimers. A brief introduction to "click" chemistry is followed by a chronological survey of developments in the field, and the impact these have had in designing novel dendritic macromolecules. The review is intended to introduce scientists to these highly efficient methodologies with demonstrated potential, and provide impetus for further growth of the area.
Photoproduction of halogens using platinized TiO2 (1981)

Unlike electrolysis of halide salt solutions, technique using powdered titanium dioxide catalyst requires no external power other than ultraviolet radiation source. Semiconductor powders photocatalyze and photosynthesize many useful reactions; applications are production of halogen molecules, oxidation of hazardous materials in wastewater, and conversion of carbon monoxide to carbon dioxide.
countries in the Middle East (1997)

~~~~~~~~~~~~~and North Afrlca wvith :a comparative advantageln in agriculture.' 8t high levels of Recent Developments and Prospects protection In 'many ofth ~~~~~~~~~~~~~~~overvalued exchange atSI Dean~~~~~~~~~~~~~~~~~~~~~~~~~~~, A. DeRosa'
SPECT imaging of dopamine and serotonin transporters with [<sup>123</sup>I]β‐CIT: Pharmacological characterization of brain uptake in nonhuman primates (1993)

Single photon emission computed tomography (SPECT) studies of regional kinetic uptake and pharmacological specificity of [123I]methyl 3 beta-(4-iodophenyl) tropane-2 beta-carboxylate ([123I]beta-CIT) were performed in nonhuman primates (n = 41). In control experiments, activity was concentrated in striatum and in hypothalamic/midbrain regions. Striatal uptake increased for 140-180 min and displayed stable levels thereafter. Striatal to cerebellar activity ratios were 7.3 +/- 0.9 (mean +/- SEM) at 300 min. About 75% of striatal uptake was displaceable by injection of nonradioactive beta-CIT. Hypothalamic/midbrain activity reached maximal levels at approximately 45 min. A slow washout phase followed this peak activity. Activities in frontal, occipital, and cerebellar regions were characterized by an early peak (20-30 min), followed by rapid washout. Displacement studies demonstrated that striatal uptake was associated with dopamine (DA) transporters, as it was displaced by GBR 12909, a selective DA uptake inhibitor, but not by citalopram, a selective serotonin (5-HT) uptake inhibitor. The inverse was true in the hypothalamic/midbrain area, suggesting that the uptake in this area was associated primarily with 5-HT transporters. Maprotiline, a selective norepinephrine uptake inhibitor, did not affect [123I]beta-CIT uptake. In vivo site occupancy ED50 values of cocaine, 2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane (CFT), and beta-CIT were measured in the striatum with a stepwise displacement paradigm. In vivo ED50 values correlated strongly with in vitro IC50 values for binding to DA transporters. Infusion of high dose of L-DOPA (250 mumol/kg) failed to displace striatal [123I]beta-CIT binding, suggesting that the binding would not be affected by L-DOPA administration in Parkinsonian patients. However, studies performed with injection of d-amphetamine indirectly suggested that high synaptic levels of DA may compete with [123I]beta-CIT binding. These studies suggest that [123I]beta-CIT will be a useful SPECT tracer of DA and 5-HT transporters in living human brain.
Effect of acute inhibition of nitric oxide synthesis by<scp>l</scp>‐NAME on cardiovascular responses following peripheral autonomic blockade in rabbits (2006)

The pressor and chronotropic responses to acute inhibition of nitric oxide synthase enzyme by N(G)-nitro-L-arginine methyl ester (L-NAME) were studied in anaesthetized rabbits with intact autonomic nervous system (ANS) activity. Also, they were investigated when administration of L-NAME was preceded by peripheral autonomic blockade. Autonomic blockade had different forms: ganglionic (hexamethonium-induced), post-ganglionic beta-adrenergic blockade (propranolol induced), parasympathetic blockade (atropine induced), and complete autonomic blockade by coadministration of hexamethonium and atropine simultaneously. L-NAME injected intravenously (10 mg/kg) in animals with intact and blocked autonomic activity induced a pressor response. This pressor response was accompanied by bradycardia in rabbits with either intact autonomic activity or hexamethonium-induced ganglionic blockade. L-NAME exerted no effect on heart rate in animals with beta-adrenergic blockade or parasympathetic blockade. In rabbits with complete autonomic blockade, L-NAME evoked tachycardia. These experiments indicate that L-NAME-induced hypertension is not relying only on ANS. Also, L-NAME-induced tachycardia in rabbits treated with atropine plus hexamethonium suggests other humoral mechanisms that may be involved in the L-NAME induced chronotropic response.
<i>The</i>UNIX<i>System</i>: A Stream Input-Output System (1984)

In a new version of the UNIX™ operating system, a flexible-coroutine-based design replaces the traditional rigid connection between processes and terminals or networks. Processing modules may be inserted dynamically into the stream that connects a user's program to a device. Programs may also connect directly to programs, providing interprocess communication.
Treatment of BXSB‐<i>Yaa</i> Mice with IL‐21R‐Fc Fusion Protein Minimally Attenuates Systemic Lupus Erythematosus (2007)

Interleukin-21 (IL-21) is a pleiotropic cytokine whose function is only now being unraveled. Abundant evidence indicates that activated CD4 T cells are the primary, if not the only, source of IL-21. While it is clear that IL-21 is actively transcribed by naïve activated T cells, recent studies have shown that IL-21 potentially promotes a developmental shift of naïve T cells toward the Th2 phenotype. BXSB-Yaa mice develop an autoimmune syndrome similar to systemic lupus erythematosus (SLE), affecting males earlier than females on account of the presence of the Yaa (Y-linked autoimmune acceleration) locus. Previous results indicate the elevation of IL-21 expression by BXSB-Yaa mice at an age when the early characteristics of autoimmune processes first become evident. We set out to determine whether IL-21 was necessary for disease progression in BXSB-Yaa mice. Mice were treated for 24 weeks with soluble IL-21R-Fc in order to therapeutically neutralize the IL-21 present. The results overall suggest a biphasic effect of IL-21, negatively influencing survival early on and positively influencing survival at later stages. We propose that IL-21 exerts a pleiotropic effect in which it promotes the protective effects of CD8+ suppressor cells in the early disease phase and then promotes the humoral components of SLE in the later disease stages. This experiment provides preliminary evidence for a role of IL-21 in modulating the severity of SLE in BXSB-Yaa mice.
Interleukin‐1β induces interleukin‐6 mRNA expression and protein production in synovial cells from human temporomandibular joint (2002)

IL-1 beta increased IL-6 production in synovial cells resulting from an increase in IL-6 mRNA expression. Enhanced production of IL-6, which is associated with bone resorption and inflammatory response, seems to be related to the progression of TMJ disorders.
Surfactant enhancement of polyethyleneglycol‐induced cell fusion (1989)

B16 mouse melanoma cells in monolayers may be satisfactorily fused with 50% PEG 1500. However, pre-treatment with detergents in solution at low concentrations significantly increases PEG fusion, up to 8-fold in some instances, without impairing cell viability. The practical and mechanistical implications of this finding are discussed.
Electric-field poling in Mg-doped LiNbO3 (2004)

We report on electric-field poling of MgO:LiNbO3 (MgLN) using patterned electrodes. Investigation of electric properties of MgLN reveals that polarization switching causes reversible resistance change and that this phenomenon can explain the physical mechanism of random domain growth. Based on these results, we propose a domain-control method in MgLN single crystals by suppressing resistance reduction during the poling process. Using this method, short periodic structures consisting of submicron domain geometries have been achieved in X-, Y-, and Z-cut MgLN crystals. High performances of these periodic domain-inverted structures are also demonstrated by evaluating their potentials as second-harmonic generation devices.
Environmental Issues in the la Plata Basin (1998)

Abstract The la Plata River basin is one of the largest in the world, with an area of about 3 million km2. It includes parts of five countries (Argentina, Bolivia, Brazil, Paraguay and Uruguay) and the water resources of the la Plata basin are essential for their economic development. The main tributaries are the rivers Parana, Paraguay and Uruguay. Some of the main developments having environmental impacts that influence the basin have been the following: (1) developments of many hydropower reservoirs in the Upper Parana River, in Brazil, from 1960-90; (2) deforestation in the Parana, Uruguay and Paraguay basins from 1950-90; (3) introduction of intensive agricultural practice after 1970; (4) urban developments with change to flood regimes; and (5) navigation and conservation of the Upper Paraguay River. Since 1970, flow increases have been observed which may have been caused by changes in vegetation cover, or by climate variation. The changes have raised important issues for both water resource development and environmental conservation. This paper discusses the water management and environmental issues, taking account of climate patterns and the development of the five countries sharing the basin.
Erythrocyte storage in hypertonic (SAGM) or isotonic (PAGGSM) conservation medium: influence on cell properties (2008)

The isotonic PAGGSM prevented the initial RBC swelling caused by citrate-phosphate-dextrose less than hypertonic SAGM, but reduced the spontaneous haemolysis rate and osmotic fragility after 42 days of storage. All other parameters, such as echinocytosis, decreased RBC deformability and aggregability, and increased blood viscosity was similar for both additive solutions and remained a major problem of blood banking.
Vacuum-Assisted Stereotactic Breast Biopsy (2000)

In summary, 11-gauge vacuum-assisted core breast biopsy accurately predicts the degree of disease in the majority of malignant lesions; however, understaging still occurs in 11% to 13% of lesions showing atypical hyperplasia or DCIS.
3D metrology system using an active triangulation with high dynamic range (2011)

We build up a new type of 3D metrology system for measuring the 3D shape of micro-structures and for reverse engineering techniques. The measurement principle is an active triangulation with a high dynamic range. The optical imaging is realized with a stereomicroscope. This features a field of view from square-centimeters down to square-millimeters at a constant triangulation angle. One port of the stereomicroscope is used to project measurement labels onto a measurement object and the second port to observe them by a camera. A calibration enables the assignment of 3D coordinates to the position of a measurement label in the camera image. To generate measurement labels we use a projection device that consists of a collimated, white light power LED illuminating a digital mirror device (DMD). The use of a DMD features the quick generation of user definable measurement labels with high brightness and contrast. Due to working with different magnifications and examining surfaces with different properties, the size and the spacing of projected measurement labels has to be adaptable. During a measurement as many measurement labels as possible should be visible in the camera image. Therefore the acquisition of measurement data from bright and dark surface areas requires a high dynamic range. The measurement labels in the camera image are distinguished with a temporal coding. This identification enables the adaption of the brightness of each measurement label in the projection pattern. As a result the dynamic of the measurement system is expanded by the dynamic of the projection device.
Sigma-delta (/spl Sigma//spl Delta/) quantization and finite frames (2006)

The K-level Sigma-Delta (/spl Sigma//spl Delta/) scheme with step size /spl delta/ is introduced as a technique for quantizing finite frame expansions for /spl Ropf//sup d/. Error estimates for various quantized frame expansions are derived, and, in particular, it is shown that /spl Sigma//spl Delta/ quantization of a unit-norm finite frame expansion in /spl Ropf//sup d/ achieves approximation error where N is the frame size, and the frame variation /spl sigma/(F,p) is a quantity which reflects the dependence of the /spl Sigma//spl Delta/ scheme on the frame. Here /spl par//spl middot//spl par/ is the d-dimensional Euclidean 2-norm. Lower bounds and refined upper bounds are derived for certain specific cases. As a direct consequence of these error bounds one is able to bound the mean squared error (MSE) by an order of 1/N/sup 2/. When dealing with sufficiently redundant frame expansions, this represents a significant improvement over classical pulse-code modulation (PCM) quantization, which only has MSE of order 1/N under certain nonrigorous statistical assumptions. /spl Sigma//spl Delta/ also achieves the optimal MSE order for PCM with consistent reconstruction.