gebhart/patrepeval huggingface dataset:
Three-Phase Oil Relative Permeability Models (1976)

American Institute of Mining, Metallurgical, and Petroleum Engineers, Inc. Abstract Two variations of an indirect technique for predicting three-phase oil relative permeability are described in this paper. permeability are described in this paper. Relative permeabilities and the dependence of waterflood residual oil saturation on trapped gas saturations predicted by these two models are compared with the three-phase experimental data available in the literature. Both models provide acceptable schemes for interpolating in the three-phase region, and qualitatively match the curvature of isoperms generated in the more carefully conducted (and previously published) threephase experiments. Limitations of each model are described, including the need for establishing derivative constraints to prevent calculation of relative permeabilities greater than unity. Guidelines are also presented for determining which model should be used in specific applications. Introduction Thorough analysis of a displacement process in which three-phase flow predominates process in which three-phase flow predominates (viz. steam drive and alternate gas/water) requires three-phase relative permeability data. The effort involved in determining these data experimentally suggests that indirect methods should be investigated. The difficulty in direct experimental work lies mainly in determination of saturation distributions along the length of the core. Electrical resistance circuits and either gamma-ray or x-ray absorption techniques are required to measure two of the three saturations in a three-phase system. Only nine experiments concerning three-phase relative permeability have been found in the literature. As an alternative to the direct methods, Stone has suggested that more easily measured two-phase data can be used to predict relative permeability to both the predict relative permeability to both the wetting and nonwetting fluids in three-phase flow. Then an indirect approach involving a technique which uses two sets of two-phase data-water/oil and gas/liquid - can be used to predict the relative permeability of the predict the relative permeability of the intermediate wettability phase. THE TWO RELATIVE PERMEABILITY MODELS Two variations of the indirect technique are described here. The first is a three-phase oil relative permeability expression developed by Hirasaki. This is a modification of a model originally proposed by Stone in 1970. The second model was presented in a paper by Stone during 1973, as a revision paper by Stone during 1973, as a revision of his first technique. Model I It has been observed experimentally in water-wet systems that the water relative permeability is approximately only a function of permeability is approximately only a function of the water saturation, and that the gas relative permeability is approximately only a function of permeability is approximately only a function of the gas saturation.
Effect of long-term electrical stimulation on vascular supply and fatigue in chronically ischemic muscles (1994)

Fast skeletal muscles of Sprague-Dawley rats [tibialis anterior (TA) and extensor digitorum longus (EDL)] were subjected to ischemia by unilateral ligation of the common iliac artery. In some animals, ischemia was combined with indirect electrical stimulation at 10 Hz either for 3 x 2 h (strenuous activity) or for 7 x 10-min bouts/day (mild activity). After 2 wk, muscle blood flow and fatigue were measured during 5-min isometric supramaximal twitch contractions at 4 Hz. Terminal arteriole diameters were assessed in TA by intravital microscopy at rest and during contractions. Vascular perfusion pressure in the muscles was estimated from measurements in the carotid and saphenous arteries below the site of ligation. Capillary supply was expressed in TA and EDL as capillary-to-fiber ratio on the basis of histochemical staining for capillaries. Strenuous stimulation of ischemic muscles increased their atrophy, failed to restore blood flow, and actually worsened fatigue. In contrast, mild stimulation improved perfusion pressure, increased capillary-to-fiber ratio in the glycolytic part of TA, restored dilatation of terminal arterioles during muscle contractions, and improved blood flow and muscle fatigue so that they were no longer significantly different from control muscles. Thus, an attenuated intermittent protocol may be indicated in the treatment of muscle ischemia.
LsaA, an Antigen Involved in Cell Attachment and Invasion, Is Expressed by<i>Lawsonia intracellularis</i>during Infection In Vitro and In Vivo (2002)

Lawsonia intracellularis has been identified recently as the etiological agent of proliferative enteropathies, which are characterized by intestinal epithelial hyperplasia and associated moderate immune responses. This disease complex has been reported in a broad range of animals, prevalently in pigs, and L. intracellularis has been linked with ulcerative colitis in humans. L. intracellularis is an obligate intracellular bacterium, and the pathogenic mechanisms used to cause disease are unknown. Using in vitro-grown organisms as a source of genomic DNA, we identified a Lawsonia gene which encodes a surface antigen, LsaA (for Lawsonia surface antigen), associated with attachment to and entry into cells. The deduced amino acid sequence of this protein showed some similarity to members of a novel protein family identified in a number of other bacterial pathogens but for which roles are not fully defined. Transcription of this gene was detected by reverse transcription-PCR in L. intracellularis grown in vitro in IEC18 cells and in bacteria present in ileal tissue from infected animals. Immunohistochemistry with specific monoclonal antibody and immunoblotting with sera from infected animals demonstrated that LsaA protein is synthesized by L. intracellularis during infection. Expression of this gene during infection in vitro and in vivo suggests that this surface antigen is involved during infection, and phenotypic analysis indicated a role during L. intracellularis attachment to and entry into intestinal epithelial cells
Investigation of the Photochemical Behaviour of ZnS Single Crystals (1964)

Abstract The photochemical effects of uv irradiation on ZnS single crystals are investigated. The crystals are exposed to short‐wavelength uv irradiation, in both high vacuum and a water vapour atmosphere. Certain crystals show weak photochemical decomposition even when irradiated in vacuum. An analysis of the experimental results shows that this is due to the water molecules, bound to the Cl or ZnCl 2 in the surface layers of the crystal. For the case of crystals irradiated in water vapour, studies are made of the degree of darkening as a function of irradiation time, also the dispersion of darkening on the crystal surface, and bleaching effects, are studied.
MicroRNA Expressions in PMBCs, CD4+, and CD8+ T-Cells from Patients Suffering from Autoimmune Addison's Disease (2013)

Autoimmune Addison's disease (AD) is a rare but potentially life threatening disease. The exact etiology of the immune response to the adrenal gland is still unknown. MicroRNAs (miRNAs) critically control gene-expression and play an important role in regulating the immune response. The aim of this study was to determine key immunoregulatory miRNAs influencing autoimmune adrenal insufficiency. For this purpose selected miRNAs were amplified by a semiquantitative SYBR Green PCR from blood mononuclear cells and after purification from CD4+ and CD 8+ cells of 6 patients with autoimmune adrenal insufficiency and 10 healthy controls. In CD4+ T-cells miRNA 181a*_1 (18.02 in AD vs. 11.99 in CG, p=0.0047) is significantly increased whereas miRNA 200a_1 (12.48 in AD vs. 19.40 in CG, p=0.0003) and miRNA 200a_2* (8.59 in AD vs. 17.94 in CG, p=0.0160) are significantly decreased. miRNA 200a_1 (12.37 in AD group vs. 18.12 in control group, p=0.001) and miRNA 200a_2* (10.72 in AD group vs. 17.84 in control group, p=0.022) are also significantly decreased in CD8+ T-cells. This study could show for the first time a significant change of three defined miRNAs in PBMCs, CD4+, and CD8+ T-cells of autoimmune AD patients in vivo. These data may help to better understand the cause of the autoimmune processes leading to autoimmune AD. They extend our very limited knowledge concerning miRNAs in autoimmune Addison's disease.
Effect of thrombopoietin on the development of megakaryocytes and platelets: an ultrastructural analysis (1996)

Megakaryocytopoiesis and platelet production can be assessed with reasonable accuracy by quantitative and functional analyses of circulating platelets. The evaluation of megakaryocytopoiesis in culture has remained unsatisfactory, particularly because platelet production is rarely observed. In mouse culture systems, megakaryocytes have been identified almost entirely by measurements of acetyl cholinesterase, size, and ploidy without concomitant assessment of maturation based on such criteria as the formation of granules, demarcation membranes, and cytoplasmic fragmentation. The availability of various thrombopoietic cytokines, in particular thrombopoietin (TPO), and their imminent clinical use has made a more detailed understanding of their effect on differentiation and maturation of the MK lineage more urgent. Therefore, ultrastructural analyses were performed on megakaryocyte-depleted serum-free mouse bone marrow cultures in the presence of TPO alone, TPO plus other cytokines, or under conditions in which TPO and/or other cytokines were blocked with neutralizing agents. These studies show that, while cytokines that use the gp130 receptor subunit may function synergistically with TPO, in the absence of TPO, such cultures do not yield morphologically recognizable MK. On the other hand, TPO alone is able to drive MK to full maturation as evidenced by the generation of granules, demarcation membranes, and cytoplasmic fragmentation into platelets.
Graph-based Isometry Invariant Representation Learning (2017)

Learning transformation invariant representations of visual data is an important problem in computer vision. Deep convolutional networks have demonstrated remarkable results for image and video classification tasks. However, they have achieved only limited success in the classification of images that undergo geometric transformations. In this work we present a novel Transformation Invariant Graph-based Network (TIGraNet), which learns graph-based features that are inherently invariant to isometric transformations such as rotation and translation of input images. In particular, images are represented as signals on graphs, which permits to replace classical convolution and pooling layers in deep networks with graph spectral convolution and dynamic graph pooling layers that together contribute to invariance to isometric transformations. Our experiments show high performance on rotated and translated images from the test set compared to classical architectures that are very sensitive to transformations in the data. The inherent invariance properties of our framework provide key advantages, such as increased resiliency to data variability and sustained performance with limited training sets.
Acute Reactogenicity after Intramuscular Immunization with Recombinant Vesicular Stomatitis Virus Is Linked to Production of IL-1β (2012)

Vaccines based on live viruses are attractive because they are immunogenic, cost-effective, and can be delivered by multiple routes. However, live virus vaccines also cause reactogenic side effects such as fever, myalgia, and injection site pain that have reduced their acceptance in the clinic. Several recent studies have linked vaccine-induced reactogenic side effects to production of the pro-inflammatory cytokine interleukin-1β (IL-1β) in humans. Our objective was therefore to determine whether IL-1β contributed to pathology after immunization with recombinant vesicular stomatitis virus (rVSV) vaccine vectors, and if so, to identify strategies by which IL-1β mediated pathology might be reduced without compromising immunogenicity. We found that an rVSV vaccine induced local and systemic production of IL-1β in vivo, and that accumulation of IL-1β correlated with acute pathology after rVSV immunization. rVSV-induced pathology was reduced in mice deficient in the IL-1 receptor Type I, but the IL-1R-/- mice were fully protected from lethal rechallenge with a high dose of VSV. This result demonstrated that IL-1 contributed to reactogenicity of the rVSV, but was dispensable for induction of protective immunity. The amount of IL-1β detected in mice deficient in either caspase-1 or the inflammasome adaptor molecule ASC after rVSV immunization was not significantly different than that produced by wild type animals, and caspase-1-/- and ASC-/- mice were only partially protected from rVSV-induced pathology. Those data support the idea that some of the IL-1β expressed in vivo in response to VSV may be activated by a caspase-1 and ASC-independent mechanism. Together these results suggest that rVSV vectors engineered to suppress the induction of IL-1β, or signaling through the IL-1R would be less reactogenic in vivo, but would retain their immunogenicity and protective capacity. Such rVSV would be highly desirable as either vaccine vectors or oncolytic therapies, and would likely be better tolerated in human vaccinees.
A Knowledge-Grounded Neural Conversation Model (2018)

Neural network models are capable of generating extremely natural sounding conversational interactions. However, these models have been mostly applied to casual scenarios (e.g., as “chatbots”) and have yet to demonstrate they can serve in more useful conversational applications. This paper presents a novel, fully data-driven, and knowledge-grounded neural conversation model aimed at producing more contentful responses. We generalize the widely-used Sequence-to-Sequence (Seq2Seq) approach by conditioning responses on both conversation history and external “facts”, allowing the model to be versatile and applicable in an open-domain setting. Our approach yields significant improvements over a competitive Seq2Seq baseline. Human judges found that our outputs are significantly more informative.
Metabolic control via nutrient-sensing mechanisms: role of taste receptors and the gut-brain neuroendocrine axis (2019)

Nutrient sensing plays an important role in ensuring that appropriate digestive or hormonal responses are elicited following the ingestion of fuel substrates. Mechanisms of nutrient sensing in the oral cavity have been fairly well characterized and involve lingual taste receptors. These include heterodimers of G protein-coupled receptors (GPCRs) of the taste receptor type 1 (T1R) family for sensing sweet (T1R2-T1R3) and umami (T1R1-T1R3) stimuli, the T2R family for sensing bitter stimuli, and ion channels for conferring sour and salty tastes. In recent years, several studies have revealed the existence of additional nutrient-sensing mechanisms along the gastrointestinal tract. Glucose sensing is achieved by the T1R2-T1R3 heterodimer on enteroendocrine cells, which plays a role in triggering the secretion of incretin hormones for improved glycemic and lipemic control. Protein hydrolysates are detected by Ca<sup>2+</sup>-sensing receptor, the T1R1-T1R3 heterodimer, and G protein-coupled receptor 92/93 (GPR92/93), which leads to the release of the gut-derived satiety factor cholecystokinin. Furthermore, several GPCRs have been implicated in fatty acid sensing: GPR40 and GPR120 respond to medium- and long-chain fatty acids, GPR41 and GPR43 to short-chain fatty acids, and GPR119 to endogenous lipid derivatives. Aside from the recognition of fuel substrates, both the oral cavity and the gastrointestinal tract also possess T2R-mediated mechanisms of recognizing nonnutrients such as environmental contaminants, bacterial toxins, and secondary plant metabolites that evoke a bitter taste. These gastrointestinal sensing mechanisms result in the transmission of neuronal signals to the brain through the release of gastrointestinal hormones that act on vagal and enteric afferents to modulate the physiological response to nutrients, particularly satiety and energy homeostasis. Modulating these orally accessible nutrient-sensing pathways using particular foods, dietary supplements, or pharmaceutical compounds may have therapeutic potential for treating obesity and metabolic diseases.
Tunable microstructures and mechanical deformation in transparent poly(urethane urea)s (2010)

Abstract Transparent poly(urethane urea) (TPUU) materials offer an avenue to enable material designs with potential to achieve simultaneous enhancements in both physical and mechanical properties. To optimize the performance required for each application, the molecular features that influence the microstructure, the glass transition temperature ( T g ), the deformation mechanisms, and the mechanical deformation behavior must be understood and exploited. In this work, a comprehensive materials characterization of select model PUUs with tunable microstructures is addressed. Increasing the hard segment (HS) content increases the stiffness and flow stress levels, whereas altering the soft segment (SS) molecular weight from 2000 to 1000 g/mol leads to an enhanced phase mixing with a SS T g shifted ∼17 °K toward higher temperatures as well as broadening of the SS relaxation closer to room temperature. As a result, the 1K TPUU materials display greater rate‐dependent stiffening and strain hardening on mechanical deformation over the broad range of strain rates covered in this work (10 −3 to 10 4 s −1 ). In such case of similar urea‐based HS content, the molar content of the urethane linkages, per stoichiometric requirements, is much higher in the 1K TPUUs than the 2K TPUUs. These additional urethane moieties lead to an increase in the extent of intermolecular interactions, via hydrogen bonding between the HS and the SS, providing not only further phase mixing and stronger rate sensitivity but also provide 1K TPUUs with drastically improved barrier properties. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2011
Cyclophilin a as a Mediator of Tissue Injure and Nephrotoxicity (2012)

Cyclophilin A (CypA) belongs to the peptidyl-prolil isomerase (PPlase) family of proteins and it is also known as the cellular receptor for cyclosporine A (CsA). CsA binds to CypA and inhibits the PPIase activity, but the CypA-CsA complex also binds to calcineurin that promotes the expression of genes encoding cytokines and other proteins required for immune response. In addition, the polymorphism variation of CypA promoter seems to have an influence on the expression of CypA in in vitro studies. CypA was also implicated in inflammatory processes (such as, among others, those observed in rheumatoid arthritis, atherosclerotic disease, nephrotoxicity) and it can be secreted by cells in response to inflammatory stimuli. CypA can also have a role in the molecular mechanisms by which CsA induces nephroxicity but these remain poorly understood. Recent studies suggest that CsA inhibition of CypA PPlase activity is a possible mechanism of this drug toxicity. In addition, CypA overexpression could be protective against CsA nephrotoxicity. Finally, the putative common mechanism by which CypA could be involved in CsA nephrotoxicity and tissue injury is related to its proinflammatory effects in cells.
Direct-Sequence Spread-Spectrum Receiver for Communication on Frequency-Selective Fading Channels (1987)

The reception of direct-sequence spread-spectrum signals on frequency-selective fading communication channels is considered. The fading statistics are described using the wide-sense-stationary uncorrelated-scattering (WSSUS) channel model. It is shown that, under certain assumptions about this channel such as time-invariance over the duration of a data symbol, an orthogonal representation for the received distorted signal can be found. The optimum incoherent receiver can then be realized with reasonable complexity. The analysis shows that exploiting the inherent diversity of a frequency-selective channel can reduce the receiver error probability by several orders of magnitude. The optimum selective channel and the jamming susceptibility of the receiver are discussed.
Transcutaneous nerve stimulation in rheumatoid arthritis. (1982)

This study of the effects of transcutaneous nerve stimulation (TNS) on 20 wrists of 11 men with rheumatoid arthritis was designd to make an objective assessment of pain and also to evaluate placebo effects. Following determinations of the length of time each wrist could support a small weight before pain began or increased (loading time), a 3-part test was conducted using the same weight in each case. (1) Each wrist was treated by TNS for 15 minutes and then, with the stimulator still on, loading time was determined (TNS-1). (2) With the stimulator working on the same wrist as for TNS-1, the loading time of the opposite wrist was determined (TNS-2). (3) To study placebo effect, loading time was again determined with the same adjustment on the stimulator but with the battery removed (TNS-3). If the loading time doubled or more, the pain relief was considered to be 100%. From the results (70% of the TNS-1 wrists had 50 to 100% pain relief; 10% of the TNS-2 and 15% of the TNS-3 wrists had some improvement), TNS appears to reduce joint pain and to offer a supplement to antiinflammatory drugs.
Role of Salicylic Acid and Fatty Acid Desaturation Pathways in <i>ssi2</i>-Mediated Signaling (2005)

Stearoyl-acyl carrier protein desaturase-mediated conversion of stearic acid to oleic acid (18:1) is the key step that regulates the levels of unsaturated fatty acids (FAs) in cells. Our previous work with the Arabidopsis (Arabidopsis thaliana) ssi2/fab2 mutant and its suppressors demonstrated that a balance between glycerol-3-phosphate (G3P) and 18:1 levels is critical for the regulation of salicylic acid (SA)- and jasmonic acid-mediated defense signaling in the plant. In this study, we have evaluated the role of various genes that have an impact on SA, resistance gene-mediated, or FA desaturation (FAD) pathways on ssi2-mediated signaling. We show that ssi2-triggered resistance is dependent on EDS1, PAD4, EDS5, SID2, and FAD7 FAD8 genes. However, ssi2-triggered defects in the jasmonic acid pathway, morphology, and cell death phenotypes are independent of the EDS1, EDS5, PAD4, NDR1, SID2, FAD3, FAD4, FAD5, DGD1, FAD7, and FAD7 FAD8 genes. Furthermore, the act1-mediated rescue of ssi2 phenotypes is also independent of the FAD2, FAD3, FAD4, FAD5, FAD7, and DGD1 genes. Since exogenous application of glycerol converts wild-type plants into ssi2 mimics, we also studied the effect of exogenous application of glycerol on mutants impaired in resistance-gene signaling, SA, or fad pathways. Glycerol increased SA levels and induced pathogenesis-related gene expression in all but sid2, nahG, fad7, and fad7 fad8 plants. Furthermore, glycerol-induced phenotypes in various mutant lines correlate with a concomitant reduction in 18:1 levels. Inability to convert glycerol into G3P due to a mutation in the nho1-encoded glycerol kinase renders plants tolerant to glycerol and unable to induce the SA-dependent pathway. A reduction in the NHO1-derived G3P pool also results in a partial age-dependent rescue of the ssi2 morphological and cell death phenotypes in the ssi2 nho1 plants. The glycerol-mediated induction of defense was not associated with any major changes in the lipid profile and/or levels of phosphatidic acid. Taken together, our results suggest that glycerol application and the ssi2 mutation in various mutant backgrounds produce similar effects and that restoration of ssi2 phenotypes is not associated with the further desaturation of 18:1 to linoleic or linolenic acids in plastidal or extraplastidal lipids.