gebhart/patrepeval huggingface dataset:
Synthesis and <i>in Vitro</i> Evaluation of the Antitubercular and Antibacterial Activity of Novel Oxazolidinones Bearing Octahydrocyclopenta[<i>c</i>]pyrrol-2-yl Moieties (2014)

A novel series of oxazolidinone-class antimicrobial agents with 5-substituted octahydrocyclopenta[c]pyrrole moieties at the C-ring of linezolid and an acetamide or 1,2,3-triazole ring as the C-5 side chain of the oxazolidinone ring were prepared. The resulting series of compounds were evaluated for in vitro antimicrobial activity against Mycobacterium tuberculosis and a panel of clinically important resistant Gram-positive and -negative bacteria. Among them, endo-alcohol 2a and exo-alcohol 2b showed potent inhibitory activity against M. tuberculosis H37Rv, which was superior to that of linezolid. Several analogues in this series showed potent in vitro antibacterial activity against the clinically important vancomycin-resistant bacteria and showed similar or better potency against linezolid-resistant methicillin-resistant Staphylococcus aureus (MRSA) strains. The hydroxyl group in the azabicyclic C-ring interacted with the same hydrophobic pocket as linezolid based on a docking study. Selected compounds with high antimicrobial activity showed good human microsomal stability and low CYP isozyme and monoamine oxidase (MAO) inhibition.
Integrated browsing and querying for image databases (2000)

The image database system El Nino uses a new interaction model that aims to overcome the problem of the semantic gap where the meaning that the user has in mind for an image is at a higher semantic level than the features on which the database operates. To solve this problem, we replaced the usual query paradigm with a more active exploration process and developed an interface based on these premises.
On the challenges of establishing disjoint QoS IP/MPLS paths across multiple domains (2006)

MPLS is being actively adopted as the core switching infrastructure at the intradomain level. This trend is mainly attributable to the undeniable potential of MPLS in terms of virtual private networks (VPNs) management, traffic engineering (TE), QoS delivery, path protection, and fast recovery from network failures. However, little progress has been made to attain the expected extension of MPLS label-switched paths (LSPs) across domain boundaries. Among the problems that remain unsolved is how to efficiently find and establish primary and protection interdomain LSPs for mission-critical services subject to QoS constraints. This article explores the major limitations hindering the deployment of these kinds of LSPs across multiple domains, in the context of the current interdomain network model. We describe the critical problems faced by the research community, and present our vision on how to rationally overcome some of the problems exposed. Our perspective is that we should be prepared for rather coarse-grained solutions as long as we need to coexist with the current interdomain network model
4‐Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading (2013)

Bromodomains are acetyllysine epigenetic mark reader proteins. Small molecules inhibiting them have potential as anti-inflammatory, antiviral, and anticancer agents. A 4-acyl pyrrole derivative (see yellow structure in recognition pocket) has been identified that potently inhibits specific bromodomains and exhibits antiproliferative activity against leukemia cell lines. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Age-Specific Prevalence of Antibody to Rotavirus, <i>Escherichia coli</i> Heat-Labile Enterotoxin, Norwalk Virus, and Hepatitis A Virus in-a Rural Community in Thailand (1983)

A serological survey in rural Thailand demonstrated that inhabitants acquired antibody to rotavirus between the ages of 6 months and 6 years, to Norwalk virus between the ages of 4 and 5 years, and to hepatitis A between the ages of 6 and 35 years. Antibody of Escherichia coli heat-labile toxin was most prevalent between 1 and 4 years and 18 and 25 years of age.
Thickness and polarity dependence of intrinsic breakdown of ultra-thin reoxidized-nitride for DRAM technology applications (2002)

This paper discusses the charge-trapping and intrinsic breakdown characteristics of ultra-thin reoxidized nitride with deep-trench capacitor structures for a range of thickness, voltages, and temperatures. Strong polarity dependence of charge-trapping and time-dependent dielectric breakdown (TDDB) is reported. For the first time, a physical model is proposed to relate the asymmetric charge injection and trapping to this intrinsic breakdown characteristic in thin reoxidized nitride. The thickness dependence of TDDB is also investigated and used for a reliability projection of the oxide equivalent thickness down to 2.9 nm.
关于“安全”的新概念 (1990)

今年是北大西洋公约组织成立40周年。各成员国对此当然感到高兴,但没人敢高枕无忧。在现代史上,他们花去了大量的时间为自己在自由中寻求和平。他们历尽艰辛才赢得两次世界大战的胜利。他们总结出的经验及教训是:第一,要防止战争,自己必须强大,有能力抵御任何潜在敌人的袭击,而且必须清醒地认识到侵略扩张是不负任何责任的;第二,防止战争不仅要有军事措施,也还要有
Creation and Application of Immortalized Bait Libraries for Targeted Enrichment and Next-Generation Sequencing (2012)

Since the introduction of next-generation sequencing, several techniques have been developed to selectively enrich and sequence specific parts of the genome at high coverage. These techniques include enzymatic methods employing molecular inversion probes, PCR based approaches, hybrid capture, and in-solution capture. In-solution capture employs RNA probes transcribed from a pool of DNA template oligos designed to match regions of interest to specifically bind and enrich genomic DNA fragments. This method is highly efficient, especially if genomic target regions are large in size or quantity. Diverse in-solution capture kits are available, but are costly when large sample numbers need to be analyzed. Here we present a cost-effective strategy for the design of custom DNA libraries, their transcription into RNA libraries, and application for in-solution capture. We show the efficacy by comparing the method to a commercial kit and further demonstrate that emulsion PCR can be used for bias free amplification and virtual immortalization of DNA template libraries.
Mechanism of the Current Doubling Effect. I. The ZnO Photoanode in Aqueous Solution of Sodium Formate (1981)

Abstract Current doubling mechanism of the photoanodic reaction of sodium formate at the ZnO electrode is re-examined. Quantitative analysis of the reaction products revealed that ZnO electrode corroded during the current doubling reaction, which has not been previously reported. However, zinc ions were formed with about 50% of current efficiency. Carbon dioxide, instead of oxygen, was formed during the reaction. These experimental observations strongly suggested mechanism proposed by earlier workers were incorrect. A new mechanism is proposed.
Contribution à la conception et à la réalisation d'interfaces tactiles portables pour les déficients visuels (2006)

Ce travail de thèse porte sur la conception et la réalisation d'un nouveau concept d'interface tactile compacte, portable, légère, à faible coût et à haute résolution. Cette interface, dédiée aux personnes aveugles et malvoyantes, est à la base d'une nouvelle approche d'aide à la mobilité basée sur la substitution/suppléance visuo-tactile. En s'appuyant sur la psychophysiologie du sens du toucher associée à une technologie d'actionnement de type Alliages à Mémoire de Forme (AMF), un dispositif mécatronique a été conçu et réalisé pour générer, via le toucher, des sensations de contact à l'extrémité des doigts. Le prototype est constitué d'une matrice de 64 micro-actionneurs en AMF de 1,5 mm de diamètre offrant des courses maximales de 1,4 mm chacun. L'espacement entre les actionneurs est de 2,6 mm. Les efforts développés par chaque actionneur sont de l'ordre de 300 mN. Enfin, la bande passante maximale sans dégradation des performances est de 1,5 Hz. Le dispositif réalisé est compact et ne pèse que 200 g. Ses faibles dimensions (un cube de 8 cm de côté) le rendent facilement portable par l'utilisateur. Des études psychophysiques conduites sur des sujets voyants montrent la pertinence de l'information transmise via l'interface et démontrent l'intérêt du dispositif réalisé pour l'assistance aux personnes aveugles et malvoyantes.
[Role of nitric oxide in heart failure]. (2000)

The benefit effects of nitric oxide (NO) donors in acute heart failure have led to the development of vasodilators as treatment of chronic heart failure. However, the mechanisms involved in the effects of NO are complex and still discussed. In chronic heart failure, the eNOS downregulation in vascular endothelium explains the alteration of endothelial function. In addition, in the myocardium, cytokines induce the expression of inducible nitric oxide synthase (iNOS) which increase NO production by myocytes and surrounding cells. This excess of NO production, associated with anion superoxide synthesis, limits the inotropic properties of catecholamines and exert proapoptotic effects. The role of NO donors in heart failure treatment is still controversial but by reducing preload they improve patient's symptoms. Beside blockade of the renin-angiotensin system, the angiotensin converting enzyme inhibitors act via the inhibition of bradykinin degradation which increase NO levels. Finally, vascular endothelial NO expression is improved by exercise training and participates in the improvement of exercise capacity in patients with chronic heart failure involved in cardiac readaptation program.
Catabolite repression of α amylase gene expression in <i>Bacillus subtilis</i> involves a trans‐acting gene product homologous to the <i>Escherichia coli lacl and galR</i> repressors (1991)

Expression of the alpha-amylase gene of Bacillus subtilis is controlled at the transcriptional level, and responds to the growth state of the cell as well as the availability of rapidly metabolizable carbon sources. Glucose-mediated repression has previously been shown to involve a site near the transcriptional start-point of the amyE gene. In this study, a transposon insertion mutation was characterized which resulted in loss of glucose repression of amyE gene expression. The gene affected by this mutation, which was localized near 263 degrees on the B. subtilis chromosomal map, was isolated and its DNA sequence was determined. This gene, designated ccpA, exhibited striking homology to repressor genes of the lac and gal repressor family. The ccpA gene was found to be allelic to alsA, previously identified as a regulator of acetoin biosynthesis, and may be involved in catabolite regulation of other systems as well.
Efficient Collision Detection between 2D Polygons (2004)

Collision detection between moving objects is an open question which raises major problems concerning its\nalgorithmic complexity. In this paper we present a polygon collision detection algorithm which uses polygon\ndecomposition through triangle coverings and polygon influence areas (implemented by signs of barycentric\ncoordinates). By using influence areas and the temporal and spatial coherence property, the amount of time\nneeded to detect a collision between objects is reduced. By means of these techniques, a valid representation for\nany kind of polygon is obtained, whether concave or convex, manifold or non-manifold, with or without holes, as\nwell as a collision detection algorithm for this type of figures. This detection algorithm has been compared with\nthe well-known PIVOT2D [Hof01] one and better results have been achieved in most situations. This\nimprovement together with its possible extension to 3D makes it an attractive method because pre-processing of\nthe polygons is no longer necessary. Besides, since this method uses sign operations, it proves to be a simple,\nmore efficient and robust method.
A default extension to description logics for use in an intelligent search engine (2002)

In companies a large amount of information is maintained that is accessible via network communication tools. This makes searching for a particular piece of information a difficult task. We identified two major difficulties that are experienced using existing search engines. These difficulties are that many of the existing search engines only take syntactic information into account and therefore do not find all relevant documents, and that many of the retrieved documents do not contain relevant information. We present a search engine that tackles both of these problems. The system, Dwebic, is based on a description logic knowledge base that deals with strict taxonomic information as well as with default information. We define this description logic and introduce a new kind of inference. Dwebic has a World Wide Web interface, but our approach does not depend on the World Wide Web.
ChemInform Abstract: Preparation of (.+‐.)‐[1,2‐<sup>13</sup>C<sub>2</sub>]Abscisic Acid for Use as a Stable and Pure Internal Standard (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Ethics of Migrant Welfare (2011)

International migration poses a dilemma for capitalist welfare states. This paper considers the ethical dimensions of that dilemma. It begins by addressing two questions associated with the provision of social rights for migrants: first, the extent to which differential forms of social citizenship may be associated with processes of civic stratification; second, the ambiguous nature of the economic, social and cultural rights components of the international human rights framework. It then proceeds to discuss, on the one hand, existing attempts to classify or taxonomise different kinds of immigration/incorporation and welfare regime and, on the other, the different ways in which migrants may be socially constructed. Building on this analysis the paper develops an alternative taxonomy that is concerned with the different ethical premises from which the social rights of migrants may be constructed or justified. The paper concludes by applying the ideal of ‘Migration without Borders’ as a means to critique existing constructions of social rights.
Utilities and Quality-Adjusted Life Years (1989)

Utilities and quality-adjusted life years (QALYs) are reviewed, with particular focus on their use in technology assessment. This article provides a broad overview and perspective on these two techniques and their interrelationship, with reference to other sources for details of implementation. The historical development, assumptions, strengths/weaknesses, and applications of each are summarized. Utilities are specifically designed for individual decision-making under uncertainty, but, with additional assumptions, utilities can be aggregated across individuals to provide a group utility function. QALYs are designed to aggregate in a single summary measure the total health improvement for a group of individuals, capturing improvements from impacts on both quantity of life and quality of life--with quality of life broadly defined. Utilities can be used as the quality-adjustment weights for QALYs; they are particularly appropriate for that purpose, and this combination provides a powerful and highly useful variation on cost-effectiveness analysis known as cost-utility analysis.
Las causas estructurales de la democracia local en México, 1989-1998 (2000)

The literature on democratic transition and consolidation has used the nation-states as its unit of analysis, leaving aside democratizing processes that take place at the subnational level using Mexico's federal states as its units of analysis. One of the most important findings of this article shows that civic-culture variables at the subnational level have little significance in explaning the current processes of democratization in Mexico's federal states.
Substrate Activation and Substrate Inhibition of Trypsin-like Enzymes from Three Strains of Streptomyces Species (1972)

Journal Article Substrate Activation and Substrate Inhibition of Trypsin-like Enzymes from Three Strains of Streptomyces Species Get access Hiroyasu NAKATA, Hiroyasu NAKATA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nobuo YOSHIDA, Nobuo YOSHIDA *Shionogi Research Laboratory, Shionogi and Co., Ltd.Fukushima-ku, Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar Yoshiko NARAHASHI, Yoshiko NARAHASHI **Polymer Chemistry Laboratory, Institute of Physical and Chemical ResearchWako, Saitama Search for other works by this author on: Oxford Academic PubMed Google Scholar Shin-ichi ISHII Shin-ichi ISHII Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 71, Issue 6, June 1972, Pages 1085–1088, https://doi.org/10.1093/oxfordjournals.jbchem.a129859 Published: 01 June 1972 Article history Received: 13 January 1972 Published: 01 June 1972
A Privacy Primer for the Web (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Secondary hyperalgesia and perceptual wind-up following intradermal injection of capsaicin in humans (1998)

Wind-up and secondary hyperalgesia both are related to central sensitization, but whereas the former is explained by homosynaptic facilitation, the latter is due to heterosynaptic facilitation. To investigate possible interactions between both types of facilitation, we tested for alterations of perceptual wind-up in the secondary hyperalgesic skin zone adjacent to a capsaicin injection with light touch (by a cotton wisp) and punctate stimuli (calibrated von Frey hairs and pin pricks). Temporal summation of pain sensation (perceptual wind-up) was only observed with a clearly noxious stimulus (pin prick) presented at a repetition frequency of 0.6 s(-1), but not 0.2 s(-1). Pain ratings to trains of pin pricks reached a plateau after 3-4 repetitions, which was 1.65 times the initial rating ('wind-up ratio'). Injection of capsaicin induced a tenderness to mechanical stimuli in adjacent uninjured skin (secondary hyperalgesia), including hyperalgesia to light touch (allodynia) and hyperalgesia to punctate stimuli. Hyperalgesia to punctate stimuli was characterized by a leftward shift of the stimulus response function, corresponding to a decrease in pain threshold and an increase of painfulness of suprathreshold stimuli by a factor of 3-4. After capsaicin, the difference between the ratings of the first and last stimuli of trains of pin pricks was increased, but the ratio was unchanged. This behavior is equivalent to an increase in effective stimulus intensity, and could be mimicked by increasing the pin prick force from 20 mN to 40 and 80 mN in normal skin. Thus, the leftward shift of the stimulus response function fully accounts for all alterations of pain sensitivity to punctate stimuli in the zone of secondary hyperalgesia. We conclude that when the gain of spinal transmission was changed in secondary hyperalgesia, the gain of wind-up remained unchanged. These findings indicate that secondary hyperalgesia (heterotopic facilitation) and wind-up of pain sensation (homotopic facilitation) are independent phenomena.
Mitigating Multi-Tenancy Risks in IaaS Cloud Through Constraints-Driven Virtual Resource Scheduling (2015)

A major concern in the adoption of cloud infrastructure-as-a-service (IaaS) arises from multi-tenancy, where multiple tenants share the underlying physical infrastructure operated by a cloud service provider. A tenant could be an enterprise in the context of a public cloud or a department within an enterprise in the context of a private cloud. Enabled by virtualization technology, the service provider is able to minimize cost by providing virtualized hardware resources such as virtual machines, virtual storage and virtual networks, as a service to multiple tenants where, for instance, a tenant's virtual machine may be hosted in the same physical server as that of many other tenants. It is well-known that separation of execution environment provided by the hypervisors that enable virtualization technology has many limitations. In addition to inadvertent misconfigurations, a number of attacks have been demonstrated that allow unauthorized information flow between virtual machines hosted by a hypervisor on a given physical server. In this paper, we present attribute-based constraints specification and enforcement as a mechanism to mitigate such multi-tenancy risks that arise in cloud IaaS. We represent relevant properties of virtual resources (e.g., virtual machines, virtual networks, etc.) as their attributes. Conflicting attribute values are specified by the tenant or by the cloud IaaS system as appropriate. The goal is to schedule virtual resources on physical resources in a conflict-free manner. The general problem is shown to be NP-complete. We explore practical conflict specifications that can be efficiently enforced. We have implemented a prototype for virtual machine scheduling in OpenStack, a widely-used open-source cloud IaaS software, and evaluated its performance overhead, resource requirements to satisfy conflicts, and resource utilization.
An adaptive error correction scheme for computer memory system (1972)

Many of the modern computer memories contain single-error correction capability in order to enhance reliability. In a large scale memory, an even more powerful error correction code may be desirable. In particular, a double-error correction capability can reduce the maintenance cost significantly, while keeping the unscheduled system interruptions within tolerable limits. Since most faults are effectively masked and logged out, the permanent failures can be replaced at the time of scheduled maintenance, thus leaving the user unaffected. The cost and complexity of the known double error correcting code, however, seems to outweigh the advantages. The long decoding time and large amount of redundancy in double error correction cannot be justified in every fetch instruction for the sake of correcting an occasional double error.