gebhart/patrepeval huggingface dataset:
Pharmacological Characterization of BR-A-657, a Highly Potent Nonpeptide Angiotensin II Receptor Antagonist (2013)

The pharmacological profile of BR-A-657, 2-n-butyl-5-dimethylamino-thiocarbonyl-methyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}-pyrimidin-4(3H)-one, a new nonpeptide AT1-selective angiotensin receptor antagonist, has been investigated in a variety of in vitro and in vivo experimental models. In the present study, BR-A-657 displaced [(125)I][Sar(1)-Ile(8)]angiotensin II (Ang II) from its specific binding sites to AT1 subtype receptors in membrane fractions of HEK-293 cells with an IC50 of 0.16 nM. In a functional assay using isolated rabbit thoracic aorta, BR-A-657 inhibited the contractile response to Ang II (pD'2: 9.15) with a significant reduction in the maximum. In conscious rats, BR-A-657 (0.01, 0.1, 1 mg/kg; intravenously (i.v.)) dose-dependently antagonized Ang II-induced pressor responses. In addition, BR-A-657 dose-dependently decreased mean arterial pressure in furosemide-treated rats and renal hypertensive rats. Moreover, BR-A-657 given orally at 1 and 3 mg/kg reduced blood pressure in conscious renal hypertensive rats. Taken together, these findings indicate that BR-A-657 is a potent and specific antagonist of Ang II at the AT1 receptor subtype, and reveal the molecular basis responsible for the marked lowering of blood pressure in conscious rats.
Production of Canola Protein Materials by Alkaline Extraction, Precipitation, and Membrane Processing (1990)

ABSTRACT A process designed for the characteristics of rapeseed and canola proteins was developed, consisting of extraction of oil‐free meal at pH 10.5–12.5, isoelectric precipitation to recover proteins and ultrafiltration followed by diafiltration to concentrate and purify the remaining acid‐soluble proteins. These steps complement one another to yield three products with excellent protein recovery. Isoelectric and soluble protein isolates containing 87–104% protein (N × 6.25) and a meal residue were obtained from canola meal. All five types of fractions were free of glucosinolates. The two isolates were low in phytate, light in color, and bland in taste. The isolate yield depended on the starting meal. The process is simple and has good potential for commercial application.
Performance of shared cache for parallel-pipelined computer systems (1983)

Shared-cache memory organizations for parallel-pipelined multiple instruction stream processors avoid the cache coherence problem of private caches by sharing single copies of common blocks. A shared cache may have a higher hit ratio, but suffers performance degradation due to access conflicts. Effective shared cache organizations are proposed which retain the cache coherency advantage and which have very low access conflict even with very high request rates. Analytic expressions for performance based on a Markov model have been found for several important cases. Performance of shared cache organizations and design tradeoffs are discussed.
Depressed contractile state and increased myocardial consumption for non-mechanical work in patients with heart failure due to old myocardial infarction (1994)

These results suggest that the VO2 for non-mechanical work in group F is disproportionately high relative to the reduced contractility. An abnormality of excitation-contraction coupling rather than of crossbridge cycling may be responsible for the impaired mechanoenergetics in patients with heart failure due to old myocardial infarction.
Run-time adaptive cache hierarchy management via reference analysis (1997)

Improvements in main memory speeds have not kept pace with increasing processor clock frequency and improved exploitation of instruction-level parallelism. Consequently, the gap between processor and main memory performance is expected to grow, increasing the number of execution cycles spent waiting for memory accesses to complete. One solution to this growing problem is to reduce the number of cache misses by increasing the effectiveness of the cache hierarchy. In this paper we present a technique for dynamic analysis of program data access behavior, which is then used to proactively guide the placement of data within the cache hierarchy in a location-sensitive manner. We introduce the concept of a macroblock, which allows us to feasibly characterize the memory locations accessed by a program, and a Memory Address Table, which performs the dynamic reference analysis. Our technique is fully compatible with existing Instruction Set Architectures. Results from detailed simulations of several integer programs show significant speedups.
A 16-bit, 125 MS/s, 385 mW, 78.7 dB SNR CMOS Pipeline ADC (2009)

A 16-bit 125 MS/s pipeline analog-to-digital converter (ADC) implemented in a 0.18 ¿m CMOS process is presented in this paper. A SHA-less 4-bit front-end is used to achieve low power and minimize the size of the input sampling capacitance in order to ease drivability. The ADC includes foreground factory digital calibration to correct for capacitor mismatches and dithering that can be optionally enabled to improve small-signal linearity. This ADC achieves an SNR of 78.7 dB, an SNDR of 78.6 dB and an SFDR of 96 dB with a 30 MHz input signal, while maintaining an SNR > 76 dB and an SFDR > 85 dB up to 150 MHz input signals. Further, with dithering enabled the worst spur is <-98 dB for inputs below -4 dBFS at 100 MHz IF. The ADC consumes 385 mW from a 1.8 V supply.
Dimethylsilanone (Me2Si:O) generation by retroene decomposition of allyloxysilanes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDimethylsilanone (Me2Si:O) generation by retroene decomposition of allyloxysilanesThomas J. Barton and Sukhamaya. BainCite this: Organometallics 1988, 7, 2, 528–531Publication Date (Print):February 1, 1988Publication History Published online1 May 2002Published inissue 1 February 1988https://pubs.acs.org/doi/10.1021/om00092a046https://doi.org/10.1021/om00092a046research-articleACS PublicationsRequest reuse permissionsArticle Views113Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oral absorption of cephalosporin antibiotics. 1. Synthesis, biological properties and oral bioavailability of 7-arylacetamido-3-chloro cephalosporins in animals (1988)

A number of 7-(arylacetamido)-3-substituted cephalosporins were prepared and tested in animals for oral absorbability. Bioavailability in mice, rats, dogs, and monkeys was determined after oral or parenteral administration. Oral bioavailability of five compounds selected for more intensive study was generally higher than that of penicillin V in all species tested. The results of ED50 testing against experimental infections in mice generally supported the bioavailability studies. Antibiotic activities were evaluated against Gram-positive and Gram-negative organisms with some derivatives expressing in vitro activity similar to cefaclor. The plasma half-life in rats was relatively short and the plasma curves were strongly influenced by probenecid, indicating rapid renal secretion. Some 7-(arylacetamido)-3-chloro cephalosporins are orally absorbed in animals to a greater extent than penicillin V, and antibacterial agent of proven clinical utility.
The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy (2010)

This work clearly indicates a protective role of Nrf2 in diabetic nephropathy, suggesting that dietary or therapeutic activation of Nrf2 could be used as a strategy to prevent or slow down the progression of diabetic nephropathy.
Homogeneous biosensor based on optical detection of the rotational dynamics of anisotropic nanoparticles (2010)

We introduce a novel biosensor concept, which employs hybrid nanoparticles consisting of magnetic nanorods encapsulated by noble metal shells. These nanoparticles have the potential to directly signal the presence of analyte molecules in the sample solution via inducing a change in their rotational dynamics on analyte binding, thus circumventing the need of extensive sample preparation. While the nanoparticles’ magnetic cores enable rotation in an external magnetic field, their shells are used to monitor their rotational dynamics through the excitation and observation of longitudinal plasmon resonances. We present model calculations on the aspired properties of suitable core-shell nanorods and first experimental results proofing the principle of this measurement method for plain Co-nanorods excited by a rotating magnetic field.
FIR parity check codes (2000)

This paper describes a method for packet synchronization and error detection for use in a synchronous digital communications system. The method relies upon a class of linear block codes that have parity checks that are expressed in terms of a finite-impulse response (FIR) filter. This system is incorporated in the newly established ITU standard of digital cable television standard, J.83 appendix B, which is based on an MPEG 2 transport packet data stream. This technique is also the basis for cable modem downstream transmission defined in the IEEE 802.14 and MCNS standards. The parity check structure is based on a pseudonoise sequence generated by a (binary) primitive polynomial. This structure allows for a computationally efficient implementation of the parity check FIR filter, in a recursive manner, that is none the less self-synchronizing. The FIR parity check codes that are described are characterized as the dual of a CRC-type, shortened cyclic code. The theory and computational structure of these codes are presented here; the J.83R code is used as an example of the general theory.
Evaluating the levels of <scp>CSF</scp> and serum factors in <scp>ALS</scp> (2017)

We demonstrated that a factor profile of ALS patients is distinct from control subjects and may be useful in clinical practice and therapeutic trials.
Hydrodynamics of the Permian Basin<xref ref-type="fn" rid="ch12fn1"><sup>1</sup></xref> (1965)

Sourced from a 1964 symposium on The Geology of Fluids, this publication brings together an array of papers dealing with many aspects of the subject. Included are 18 papers covering basin-specific research as well as basic research on fluids in subsurface environments.
A Method for Seat Occupancy Detection for Automobile Seats with Integrated Heating Elements (2009)

Abstract − Seat occupancy detection systems based on a capacitive or an electric field principle, developed for an automobile seat, may not work well for seats with integrated electric heating systems. A new detection method, suitable for this type of automobile seats, is presented in this paper. In the proposed scheme, the heating element is a part of the sensor system while its operation as a heating element is kept unaffected. Results obtained from a prototype system demonstrate the practical validity of the method.
Microstructural analysis of non-woven fabrics using scanning electron microscopy and image processing. Part 1: Development and verification of the methods (2002)

This paper reports image analysis methods that have been developed to study the microstructural changes of non-wovens made by the hydroentanglement process. The validity of the image processing techniques has been ascertained by applying them to test images with known properties. The parameters in preprocessing of the scanning electron microscope (SEM) images used in image processing have been tested and optimized. The fibre orientation distribution is estimated using fast Fourier transform (FFT) and Hough transform (HT) methods. The results obtained using these two methods are in good agreement. The HT method is more demanding in computational time compared with the Fourier transform (FT) method. However, the advantage of the HT method is that the actual orientation of the lines can be concluded directly from the result of the transform without the need for any further computation. The distribution of the length of the straight fibre segments of the fabrics is evaluated by the HT method. The effect of curl of the fibres on the result of this evaluation is shown.
Stereocontrolled Synthesis of ψ[CH(CF<sub>3</sub>)NH]Gly-Peptides (2003)

[reaction: see text] A novel class of peptidomimetics having a stereogenic [CH(CF(3))NH] replacement for a [CONH] peptide bond has been synthesized. The new compounds have been obtained in a stereocontrolled fashion using a kinetically controlled aza-Michael addition of chiral alpha-amino acid esters to trans-3,3,3-trifluoro-1-nitropropene. The stereoselectivity is strongly influenced by the solvent, the base, its stoichiometry, and the R side-chain. Diastereomeric ratios higher than 11:1 were achieved using H-Val-OtBu.HCl in toluene with 1.1 equiv of DIPEA.
Improved resolution in the detection of oligonucleotides up to 60-mers in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using pulsed-delayed extraction with a simple high voltage transistor switch (1997)

Pulsed-delayed extraction using a simple high voltage transistor switch together with various sample purification approaches were used to enhance the resolution in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) of oligonucleotides up to 60 bases long. This switch can provide a 0-3 kV voltage pulse with a 75 ns fall time. A resolution of 500-900 was typically observed for samples from 5-mers to 60-mers using pulsed-delayed extraction (PDE) with the switch described herein. The resolution deteriorated to < 100 for oligonucleotides of > or = 65-mers. With the TOF acceleration region configuration used in this work, the resolution was found not to vary significantly over a delay range of 2-5 mus. As the DNA size increased to over 35-mer, HPLC purification was required to retain the enhancement in resolution provided by PDE MALDI-MS.
Josephson Junction Detectors (1974)

How can I measure a voltage of 10 V? Can I detect the magnetic field generated by the human brain?What is the most sensitive detector of far infrared signals reaching us from distant galaxies?The answers to these seemingly unconnected problems, and to others requiring very sensitive instrumentation, are being provided to an increasing extent by devices based on Josephson junctions (1).These devices offer unprecedented sensitivity in certain applications, and enable us to measure incredibly small signals that are totally inaccessible to other instruments.The Josephson effect is a superconducting phenomenon, and occurs only at temperatures below a few degrees Kelvin.Consequently, until recently operation of Josephson devices was restricted to the low-temperature physics laboratory.However, with the advent of robust and portable cryostats, these instruments are now being used in the field in a variety of applications.In this article, I will explain the principles of the Josephson effect, describe how practical devices have been made, and discuss some of the applications.I have divided the applications into two broad classes.The first involves the measurement of voltages, magnetic fields, magnetic field gradients, and magnetic susceptibilities at or below audio frequencies (2).In these areas, the Josephson devices have no competitors.The second class is concerned with the detection of high frequency (microwave and far infrared) electromagnetic radiation (2).In this application, the Josephson devices appear to be comparable in performance with other detectors, but improvements are likely to be made in the reasonably near future.In this short review, I have not been able to even mention a great
Multiple Secret Keys based Security for Wireless Sensor Networks (2012)

We propose a security approach that uses secret key cryptography and key management along with re-keying support. A salient feature of our approach is that a secret key is embedded in the source code of every node to protect the other keys in its non-volatile memory. Even the node is captured physically; the sensitive information cannot be retrieved. Our key selection protocol uses the node ID and some basic rotate and multiplication function to select the key for current data transmission. Because of this dynamic key selection, our approach identifies the replay attack, DoS attack and Sybil attack. Our simulation results shows that our security mechanism efficiently controls various attacks with lower resource requirements and the network resilience against node capture is substantially improved.
AutoEDES: a model-based Bayesian framework for automatic end-diastolic and end-systolic frame selection in angiographic image sequence (2008)

This paper presents a novel approach to automatically detect the end-diastolic (ED) and end-systolic (ES) frames from an X-ray left ventricular angiographical image sequence. ED and ES image detection is the first step for widely used left ventricular analysis in catheterization lab. However, due to the inherent difficulties of X-ray angiographical image, automatic ED and ES frame selection is a challenging task and still remains unsolved. The current clinical practice uses manual selection, which is not only time consuming but also sensitive to different persons at different time. In this paper, we propose to formulate the X-ray angiogram by a dynamical graphical model. Then the posterior density of the left ventricular state is estimated by using Bayesian probability density propagation and adaptive background modeling. Preliminary experimental results have demonstrated the superior performance of the proposed algorithm on clinical data.
Purification and characterization of a thermostable, haloalkaliphilic extracellular serine protease from the extreme halophilic archaeon <i>Halogeometricum borinquense</i> strain TSS101 (2006)

A novel haloalkaliphilic, thermostable serine protease was purified from the extreme halophilic archaeon, Halogeometricum borinquense strain TSS101. The protease was isolated from a stationary phase culture, purified 116-fold with 18% yield and characterized biochemically. The molecular mass of the purified enzyme was estimated to be 86 kDa. The enzyme showed the highest activity at 60 degrees C and pH 10.0 in 20% NaCl. The enzyme had high activity over the pH range from 6.0 to 10.0. Enzymatic activity was strongly inhibited by 1 mM phenyl methylsulfonyl fluoride, but activity was increased 59% by 0.1% cetyltrimethylammonium bromide. The enzyme exhibited relatively high thermal stability, retaining 80% of its activity after 1 h at 90 degrees C. Thermostability increased in the presence of Ca2+. The stability of the enzyme was maintained in 10% sucrose and in the absence of NaCl.
<i>In vitro</i> Sensitivity Test of Breast Cancer Cells to Hormonal Agents in a Radionucleotide‐incorporation Assay (1990)

Breast cancer cell lines (MCF-7, T47D, BT-20 and STT-11) and fresh cells from malignant effusions of eight breast cancer patients were examined for their in vitro sensitivity to 17 beta-estradiol (E2), tamoxifen and toremifene in a miniaturized, improved nucleic acid precursor incorporation assay (MINI assay). Seven of the eight patients received either tamoxifen or toremifene following a MINI assay and the correlation was examined between in vitro sensitivity and clinical responses to the hormonal agents. In cell lines, E2 stimulated thymidine incorporation by estrogen receptor (ER)-rich cells, MCF-7 and T47D, but not by ER-poor cells, BT-20 and STT-11. Tamoxifen induced both ER-mediated and -unmediated effects in ER-rich cells. The latter effect was also observed in ER-poor cells. Toremifene had less ER-unmediated effect in all of the cells tested than tamoxifen did. The ER-mediated effect of toremifene was weaker than that of tamoxifen in cell lines but was equipotent to tamoxifen in fresh cells. E2 affected thymidine incorporation by cells withdrawn from patients who showed a partial response to the anti-estrogens. No clear correlation was demonstrated between in vitro sensitivity to anti-estrogens of fresh cells and clinical response to these agents. The present results suggest that 1) the MINI assay is a useful system to investigate hormonal effects on breast cancer cell lines; 2) clinical responses to anti-estrogens are not predicted by in vitro response to the agents but might be predicted by the in vitro response to E2; and 3) toremifene has a smaller non-specific effect on breast cancer cells than tamoxifen and is equipotent to tamoxifen in the ER-mediated effect in vitro.
Mica-Loaded Paper for EHV Power Cable (1969)

The paper deals with mica-loaded kraft paper developed with the aim of applying it to the extra-high-voltage oil-filled (OF) cable and pipe-type OF cable and an outline of an experimental 275-kV OF cable containing mica-loaded kraft paper.
Mechanisms of endotoxin tolerance. The role of the spleen. (1975)

Splenectomy markedly impaired the production of circulating anti-endotoxin antibodies during the initial 10 days after .v. administration of a Boivin preparation of Escherichia coli endotoxin (ET) in both rabbit and man. Increase in antibodies with secondary (flocculating and bactericidal) activities were virtually abolished, whereas increases in antibodies with primary (binding) activity were significantly reduced. On the basis of these findings, splenectomized rabbit and man were employed to test the hypothesis that the early phase (less than 72 h) of pyrogenic tolerance to endotoxin is independent of anti-endotoxin antibody but that such antibody contributes significantly to the later phase (less than or equal to 72 h) of tolerance. In the splenectomized rabbit, the initial pyrogenic reponses to ET and the subsequent tolerant responses at 24 and 48 h were comparable to sham-operated controls...
DINA Model and Parameter Estimation: A Didactic (2008)

Cognitive and skills diagnosis models are psychometric models that have immense potential to provide rich information relevant for instruction and learning. However, wider applications of these models have been hampered by their novelty and the lack of commercially available software that can be used to analyze data from this psychometric framework. To address this issue, this article focuses on one tractable and interpretable skills diagnosis model—the DINA model—and presents it didactically. The article also discusses expectation-maximization and Markov chain Monte Carlo algorithms in estimating its model parameters. Finally, analyses of simulated and real data are presented.