gebhart/patrepeval huggingface dataset:
Low-phytate protein concentrate and isolate from sesame seed (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLow-phytate protein concentrate and isolate from sesame seedF. S. Taha, M. Fahmy, and M. A. SadekCite this: J. Agric. Food Chem. 1987, 35, 3, 289–292Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://doi.org/10.1021/jf00075a001RIGHTS & PERMISSIONSArticle Views184Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (459 KB) Get e-Alerts Get e-Alerts
Ferromagnetism in hexagonal-close-packed elements (1989)

The Stoner theory of ferromagnetism has been applied to 3d transition metals in the hexagonal-close-packed (hcp) phase. The elements Co and Ni (and possibly Cr) are found to be ferromagnetic. A self-consistent calculation of the band structure of paramagnetic hcp Ni revealed the highest-known density of states at the Fermi level of any transition metal in any structure, providing strong evidence for ferromagnetism. A first-principles, spin-polarized band-structure calculation for hcp Ni yielded a stable magnetic moment of 0.76${\ensuremath{\mu}}_{B}$ per atom and an average spin splitting of 0.1 Ry.
Antipneumocystis activity of 17C91, a prodrug of atovaquone (1995)

The prophylactic efficacy of 17C91, a carbamate prodrug of atovaquone (ATQ), was investigated in a severe combined immunodeficient mouse model of Pneumocystis carinii pneumonia (PCP). At an oral dosage equivalent to 100 mg of ATQ per kg of body weight per day, 17C91 protected 9 of 10 mice from PCP and had a prophylactic efficacy comparable to that of co-trimoxazole (at 250 mg of sulfamethoxazole plus 50 mg of trimethoprim per kg per day orally). The intensity of P. carinii infection (infection score) of mice treated with 17C91 correlated with the concentration of ATQ in the plasma, with clearance of the infection associated with plasma ATQ levels of >35 micrograms/ml. 17C91 given orally provided enhanced levels of ATQ in the plasma compared with the conventional ATQ formulation. Additional studies reported in this paper demonstrate that the prophylactic activity of 17C91 against PCP in severe combined immunodeficient mice is comparable to that of a new oral microparticulate formulation of ATQ.
Electronics as an Academic Subject (1993)

Electronics as an academic subject This paper decribes the philosophy of a broad course in electronics based on a precise definition of the subject. The main themes and structure of such courses are discussed. Links between the themes show the unity of the subject. Breadth is particularly useful in education for a long-term career in electronics.
Recent developments in superconducting tunnel junctions forultraviolet, optical & near infrared astronomy (1998)

Some recent results associated with the development of tantalum based photon counting superconducting tunnel junctions (STJ) suitable for use as broad-band low resolution spectrometers for optical and ultraviolet astronomy are presented. A m square tantalum based STJ, operated at a temperature of 0.3 K, has demonstrated a limiting resolution of nm at 200 nm and nm at 1000 nm. The device is extremely linear in response with photon energy, and covers the waveband from 200 nm to while measuring the individual photon wavelength and arrival time. The short wavelength limit is currently constrained by the current experimental configuration (a fibre optic) as well as to some extent the sapphire substrate. The estimated quantum efficiency for single photons is over between 200 and 700 nm with a maximum of at 550 nm. Such an STJ when packaged into an array could contribute significantly to many fields of near infrared, optical and ultraviolet astronomy being able to provide efficiently and simultaneously the broad band spectrum and photon arrival time history of every single object in the field over a very wide dynamic range.
ABCB8 Mediates Doxorubicin Resistance in Melanoma Cells by Protecting the Mitochondrial Genome (2009)

Despite their initial effectiveness in the treatment of melanoma, chemotherapeutic agents are ultimately futile against this most aggressive form of skin cancer, and patients inevitably succumb to the disease. One of the mechanisms by which residual melanoma cells become chemoresistant is via the decreased efficiency of chemotherapeutics through the action of ATP-binding cassette (ABC) proteins that are variably expressed by the tumor cells. The clinical relevance of the ABC transporters in the context of cancer is paramount. Inhibitors of these transporters have been shown to increase the efficacy of standard therapy in experimental systems. Their clinical application requires better understanding of the role individual transporters play in the mechanism and the development of more specific inhibitors with minimal off target effects. ABC transporters in tumor cells have been shown to confer multidrug resistance in many solid tumors. However, their role in melanomas is far from clear. Here, we prospectively identify ABCB8 as a specific and major player in the chemoresistance of several melanoma cell lines. ABCB8 knockdown with shRNA reduced doxorubicin resistance approximately 3- to 4-fold in these cells. Furthermore, we show that this reversal is specific to doxorubicin and not to other commonly used chemotherapeutics. Our results also provide evidence that ABCB8 conferred resistance through the protection of mitochondrial DNA from doxorubicin-induced DNA damage.
Mechanism of the Susceptibility of Remodeled Pulmonary Vessels to Drug‐Induced Cell Killing (2014)

These results suggest that antitumor drugs can specifically kill cells in remodeled pulmonary vascular walls and may be useful for improving the efficacy of current therapeutic strategies to treat pulmonary arterial hypertension.
Cross-lingual Entity Alignment via Joint Attribute-Preserving Embedding (2017)

Entity alignment is the task of finding entities in two knowledge bases (KBs) that represent the same real-world object. When facing KBs in different natural languages, conventional cross-lingual entity alignment methods rely on machine translation to eliminate the language barriers. These approaches often suffer from the uneven quality of translations between languages. While recent embedding-based techniques encode entities and relationships in KBs and do not need machine translation for cross-lingual entity alignment, a significant number of attributes remain largely unexplored. In this paper, we propose a joint attribute-preserving embedding model for cross-lingual entity alignment. It jointly embeds the structures of two KBs into a unified vector space and further refines it by leveraging attribute correlations in the KBs. Our experimental results on real-world datasets show that this approach significantly outperforms the state-of-the-art embedding approaches for cross-lingual entity alignment and could be complemented with methods based on machine translation.
Health, Inequality, and Economic Development (2003)

I explore the connection between income inequality and health in both poor and rich countries. I discuss a range of mechanisms, including nonlinear income effects, credit restrictions, nutritional traps, public goods provision, and relative deprivation. I review the evidence on the effects of income inequality on the rate of decline of mortality over time, on geographical pattens of mortality, and on individual-level mortality. Much of the literature needs to be treated skeptically, if only because of the low quality of much of the data on income inequality. Although there are many puzzles that remain, I conclude that there is no direct link from income inequality to ill-health; individuals are no more likely to die if they live in more unequal places. The raw correlations that are sometimes found are likely the result of factors other than income inequality, some of which are intimately linked to broader notions of inequality and unfairness. That income inequality itself is not a health risk does not deny the importance for health of other inequalities, nor of the social environment. Whether income redistribution can improve population health does not depend on a direct effect of income inequality and remains an open question.
C4NP technology: Manufacturability, yields and reliability (2008)

As a part of IBM movement from Pb-rich solders to Pb-free solder, a new low cost process has been developed to deposit the solder to a capture, or under bump metal (UBM) pad, with Suss MicroTech Inc as the equipment partner. The controlled collapsed chip connection new process (C4NP) has moved, over the last 2 years, from development into manufacturing for 300 mm wafers. During this transition, a great number of process improvements have resulted in high fabrication yields. Manufacturing robustness has been achieved by clearly identifying the processes which affect the C4 structural integrity. The solder composition has been optimized to improve its mechanical properties as well as low alpha emission rate requirement. Sector partitioning methodology was used to obtain root cause for various defects which then, through replication studies, were confirmed. Key process improvements in the capture pad build, mold fabrication, and mold fill tool have been accomplished as the process has matured. Thermal undercut was identified as a mechanism of Cu seed consumption when no top Cu was available on top of the Ni UBM. C4NP technology can produce yields comparable to that of electroplated C4 Bumps. Yield learning model shows a 15% defect reduction per month since the start of the C4NP program. Technology qualification for 300 mm wafers with 200um and 150 um pitch Pb-free C4 bumps has been successfully completed.
Sampling and Reconstruction Using Bloom Filters (2017)

In this paper, we address the problem of sampling from a set and reconstructing a set stored as a Bloom filter. To the best of our knowledge our work is the first to address this question. We introduce a novel hierarchical data structure called BloomSampleTree that helps us design efficient algorithms to extract an almost uniform sample from the set stored in a Bloom filter and also allows us to reconstruct the set efficiently. In the case where the hash functions used in the Bloom filter implementation are partially invertible, in the sense that it is easy to calculate the set of elements that map to a particular hash value, we propose a second, more space-efficient method called HashInvert for the reconstruction. We study the properties of these two methods both analytically as well as experimentally. We provide bounds on run times for both methods and sample quality for the BloomSampleTree based algorithm, and show through an extensive experimental evaluation that our methods are efficient and effective.
Little Points of Light (2011)

The article discusses several approaches in determining the spectroscopic aspects of the stars and the galaxy formulated by various astronomer. It notes that astronomer Norman Robert Pogson created a magnitude system to analyzes the perceived brightness of the stars by differentiating between the apparent magnitude and the absolute magnitude. It mentions on the development of the Hubble's law by astronomer Edwin Hubble and Milton Humason to determine the spectra of a collection of galaxies.
Cardiac resynchronization therapy in combination with implantable cardioverter-defibrillator (2009)

Device therapy for heart failure has a spectacular development during the last 10 years. Patients with chronic heart failure might benefit from electrical therapy with a view to: (i) resynchronize the failing and dyssynchronized heart and improve its mechanical performance or (ii) prevent the risk of sudden death by automatic defibrillation. These two therapies can be applied together with a combined device, the biventricular implantable cardioverter-defibrillator (CRT-D). Today, the proportion of CRT-D devices among all CRT devices implanted around the world is more than 75% and more than 85% in the USA. This review article will try to answer some important questions for clinical practice: is the growing use of CRT-D devices supported by clinical evidence? Is the risk-benefit profile of CRT-D favourable in particular in mildly symptomatic patients?
On the Mechanism of Homogeneous Decomposition of the Chlorinated Silanes. Chain Reactions Propagated by Divalent Silicon Species (1998)

A mechanism for the homogeneous gas-phase decomposition of SiHCl3, SiH2Cl2, and SiH3Cl in hydrogen is derived from the results of ab initio molecular-orbital studies. It consists of 39 reversible elementary reactions among 25 species, including pressure-dependent unimolecular decomposition of the chlorinated silanes and secondary chemistry due to reactions of SiH2, SiHCl, and SiCl2 with one another and with the chlorinated silanes. Rate parameters in the mechanism have been calculated based on results of ab initio studies using transition-state theory and unimolecular rate theories. This allows us to construct a reasonably complete mechanism that provides qualitative explanations for several features of dichlorosilane decomposition that have been presented in the literature, including observations on the presence and concentrations of SiCl2, SiHCl, and Si atoms. Several chain reactions in which the chain carriers are divalent silicon species have been identified.
Use of Frequency-Selective Surface for Suppressing Radio-Frequency Interference from Wireless Charging Pads (2013)

Wireless charging is an emerging technology that involves multidisciplinary research. Power converters driving the planar wireless charging pads generate radio-frequency interference (RFI) that can degrade the signal transmission and reception of portable communication devices such as mobile phones. In this paper, the practical evidence of the RFI arising from the switching electronics in a wireless charging pad is provided and the use of a frequency-selective surface (FSS) is proposed for reducing the RFI. The basic principle of using the FSS design, previously used for stealth applications, is explained and practically verified for suppressing the RFI in wireless charging pads. The FSS structures show good RFI blocking performance with negligible effect on the charging energy efficiency. Practical tests have confirmed that the maximum sensitivity of the phone can be improved by 6.5–8.4 dB in GSM900 and by 2.3–6.3 dB in GSM850 when a double-sided FSS is employed. Moreover, the total isotropic sensitivity is improved by 3.3–5.6 dB in GSM900 and 0.2–3.3 dB in GSM850. The proposed FSS can become a low-cost accessory to the wireless charging pads for portable electronics.
MMW mobile terminal positioning using remote receivers (2017)

This paper mentioned the function of mobile terminal positioning for beam forming to millimeter-wave terminals in high-density user environment. The positioning method discussed in this paper is hyperbolic positioning using time differences of arrival of the millimeter wave signals from mobile terminals. Some preliminary time measurement experiments of millimeter wave have been executed with RoF connection remote receivers developed for this positioning purpose. In addition, simulation study also has been made to estimate the positioning accuracy. As a result, high accuracy positioning of millimeter wave mobile terminal seemed to be achieved.
A Circle Has No End: Role of Cyclic Topology and Accompanying Structural Reorganization on the Hole Distribution in Cyclic and Linear Poly-<i>p</i>-phenylene Molecular Wires (2015)

π-Conjugated organic oligomers/polymers hold great promise as long-range charge-transfer materials for modern photovoltaic applications. However, a set of criteria for the rational design of functional materials is not yet available, in part because of a lack of understanding of charge distribution in extended π-conjugated systems of different topologies, and concomitant effects on redox and optical properties. Herein we demonstrate the role of cyclic versus linear topology in controlling the redox/optical properties and hole distribution in poly-p-phenylenes (PPs) with the aid of experiment, computation, and our recently developed multistate parabolic model (MPM). It is unequivocally shown that the hole distribution in both cyclic and linear poly-p-phenylene (n ≥ 7) cation radicals is limited to seven p-phenylene units, despite the very different topologies. However, the effect of topology is evidenced in the very different trends in oxidation potentials of cyclic versus linear PPs, which are shown to originate largely from the geometrical distortion of individual p-phenylene units in cyclic PPs. The presence of additional pairwise electronic coupling element in cyclic PPs, absent in linear PPs, plays a significant role only in smaller cyclic PP5 and PP6. This study provides a detailed conceptual description of cyclic and linear poly-p-phenylene cation radicals and demonstrates the versatility and predictive power of MPM, an important new tool for the design and synthesis of novel and efficient charge-transfer materials for molecular electronics and photovoltaic applications, an area of widespread interest.
Cloning and Functional Expression of a Human Kidney Na+:HCO3−Cotransporter (1997)

Several modes of HCO3- transport occur in the kidney, including Na+-independent Cl/HCO3- exchange (mediated by the AE family of Cl-/HCO3- exchangers), sodium-dependent Cl-/HCO3- exchange, and Na+:HCO3- cotransport. The functional similarities between the Na+-coupled HCO3- transporters and the AE isoforms (i.e. transport of HCO3- and sensitivity to inhibition by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid) suggested a strategy for cloning the other transporters based on structural similarity with the AE family. An expressed sequence tag encoding part of a protein that is related to the known anion exchangers was identified in the GenBankTM expressed sequence tag data base and used to design an oligonucleotide probe. This probe was used to screen a human kidney cDNA library. Several clones were identified, isolated, and sequenced. Two overlapping cDNA clones were spliced together to form a 7.6-kilobase cDNA that contained the entire coding region of a novel protein. Based on the deduced amino acid sequence, the cDNA encodes a protein with a Mr of 116,040. The protein has 29% identity with human brain AE3. Northern blot analysis reveals that the 7.6-kilobase mRNA is highly expressed in kidney and pancreas, with detectable levels in brain. Functional studies in transiently transfected HEK-293 cells demonstrate that the cloned transporter mediates Na+:HCO3- cotransport.
Anti-cancer Drug Response Prediction Using Neighbor-Based Collaborative Filtering with Global Effect Removal (2018)

Patients of the same cancer may differ in their responses to a specific medical therapy. Identification of predictive molecular features for drug sensitivity holds the key in the era of precision medicine. Human cell lines have harbored most of the same genetic changes found in patients' tumors and thus are widely used in the research of drug response. In this work, we formulated drug-response prediction as a recommender system problem and then adopted a neighbor-based collaborative filtering with global effect removal (NCFGER) method to estimate anti-cancer drug responses of cell lines by integrating cell-line similarity networks and drug similarity networks based on the fact that similar cell lines and similar drugs exhibit similar responses. Specifically, we removed the global effect in the available responses and shrunk the similarity score for each cell line pair as well as each drug pair. We then used the K most similar neighbors (hybrid of cell-line-oriented and drug-oriented) in the available responses to predict the unknown ones. Through 10-fold cross-validation, this approach was shown to reach accurate and reproducible outcomes of drug sensitivity. We also discussed the biological outcomes based on the newly predicted response values.
Preparation and Characterization of Temperature-Sensitive Poly(<i>N</i>-isopropylacrylamide)-<i>b</i>-poly(<scp>d</scp>,<scp>l</scp>-lactide) Microspheres for Protein Delivery (2003)

Temperature-sensitive diblock copolymers, poly(N-isopropylacrylamide)-b-poly(D,L-lactide) (PNIPAAm-b-PLA) with different PNIPAAm contents were synthesized and utilized to fabricate microspheres containing bovine serum albumin (BSA, as a model protein) by a water-in-oil-in-water double emulsion solvent evaporation process. XPS analysis showed that PNIPAAm was a dominant component of the microspheres surface. BSA was well entrapped within the microspheres, and more than 90% encapsulation efficiency was achieved. The in vitro degradation behavior of microspheres was investigated using SEM, NMR, FTIR, and GPC. It was found that the microspheres were erodible, and polymer degradation occurred in the PLA block. Degradation of PLA was completed after 5 months incubation in PBS (pH 7.4) at 37 degrees C. A PVA concentration of 0.2% (w/v) in the internal aqueous phase yielded the microspheres with an interconnected porous structure, resulting in fast matrix erosion and sustained BSA release. However, 0.05% PVA produced the microspheres with a multivesicular internal structure wrapped with a dense skin layer, resulting in lower erosion rate and a biphasic release pattern of BSA that was characterized with an initial burst followed by a nonrelease phase. The microspheres made from PNIPAAm-b-PLA with a higher portion of PNIPAAm provided faster BSA release. In addition, BSA release from the microspheres responded to the external temperature changes. BSA release was slower at 37 degrees C (above the LCST) than at a temperature below the LCST. The microspheres fabricated with PNIPAAm-b-PLA having a 1:5 molar ratio of PNIPAAm to PLA and 0.2% (w/v) PVA in the internal aqueous phase provided a sustained release of BSA over 3 weeks in PBS (pH 7.4) at 37 degrees C.