gebhart/patrepeval huggingface dataset:
Normal trophoblasts resist induction of class I HLA. (1987)

Very few types of normal cells fail entirely to express class I human leukocyte antigens (HLA), and many of those cells (sperm, fetal amnion epithelial cells, and fetal trophoblasts) are related to the process of reproduction. Susceptibility of sperm to modulation of class I antigens has not been examined, but it has recently been demonstrated that amnion cells respond to exposure to IFN-gamma with readily detectable levels of class I antigens. In addition, one of two trophoblast cell lines (BeWo) has been shown to exhibit enhanced expression of class I HLA in response to IFN-gamma. Expression by a second trophoblast cell line (Jar) was not inducible. Findings in the present study included demonstration of IFN-gamma-enhanced class I-specific mRNA synthesis in JEG-3 cells, which are derived from BeWo, and failure of synthesis by Jar cells. Those results eliminated trivial explanations for the preceding findings and confirmed the responsiveness of some but not all cells of trophoblast origin to IFN-gamma. When successful modulating conditions for amnion and malignant trophoblast cells were applied to normal tissues, third trimester term chorionic cytotrophoblasts and first trimester villous syncytial and cytotrophoblasts failed to exhibit class I HLA. Neither malignant nor normal trophoblasts expressed class II HLA under any condition of testing. Failure of induction of HLA expression by normal trophoblasts could not be attributed to either loss of viability by tissue explants or failure of modulating reagents to reach the trophoblasts. The results demonstrate that regulation of expression of histocompatibility antigens by major populations of normal trophoblasts and one of two choriocarcinoma cell lines differs markedly from that of other fetal and adult cells. Uncommon regulatory mechanisms may be essential to maintenance of the trophoblast as an immunologically inert barrier between the mother and her antigenically disparate fetus.
Identification of roofs perimeter from aerial and satellite images (2011)

The computer-driven extraction of roofs perimeter is a very important step in 3D reconstruction of buildings as it allows to reduce human interactions. In this context, very high resolution optical images, from airborne surveys or from satellites, were used in this paper with the aim of extracting such information. The proposed method is based on a color image segmentation algorithm. The seed-growing approach has been considered, thanks to its capability and sensitivity in local analysis. A multi-seed method is presented, characterized by an adaptive growing mechanism and able to estimate internal parameters on the basis of the image under analysis. A further simplification to the user is given, since an automatic extraction of seed points has been introduced, that is fundamental for a complete image segmentation. Different images have been tested and experimental results prove the effectiveness of the proposed method.
Pyloric Campylobacter infection and gastroduodenal disease (1985)

In 1982, a new spiral Gram-negative bacterium which was similar to those of the genus Campylobacter was isolated from the gastric mucosa of 11 patients with gastritis. From then on, the organism was isolated in a further 114 of 267 patients who underwent antral biopsy in Fremantle Hospital between January 1983 and September 1984. During 1984, the bacterium was cultured from 88% of patients in whom it was detected histologically, and was not cultured from any patient with histologically normal gastric mucosa. The new bacterium, pyloric campylobacter, grew in three days on brain-heart infusion blood-agar at 37 degrees C in an atmosphere with added CO2. All isolates tested were sensitive to penicillin, erythromycin, tetracycline, cephalosporins, gentamicin and bismuth citrate; 80% of isolates were sensitive to metronidazole or tinidazole. It is suggested that pyloric campylobacter infection is a major factor in the causation of dyspeptic disease and peptic ulceration. Antibacterial regimens directed against the bacterium may provide a permanent cure for these chronic disorders.
Trajectory Planning for Saving Energy of 3-Link Manipulator (2000)

It is important to save the dissipated energy of manipulators for improving the environment of the earth which is being warmed up by CO2 gas emitted from thermal power plants. This paper describes an optimal trajectory which minimizes the dissipated energy in PTP motion of a 3-link manipulator. The two-point boundary-value problem is derived to get the optimal trajectory from Euler canonical equation. A generalized Newton-Raphson method is time-consuming to converge the optimal solution because the manipulator has many links and strong non-linearity. After using the method one time for short operating time which is liable to converge, a shooting method is applied to solve the optimal trajectory with various operating times. It is important for these iteration methods to select the starting velocity functions so as not to fall into a local optimal solution. In order to attain to a globally optimal path, this paper proposes a starting velocity function which the heavier link is accelerated toward gravitational direction and decelerated toward anti-gravitation. It is shown from simulation that the proposed optimal path can lessen the dissipated energy in comparison to conventional path.
Direct-detection optical cdma receiver with interference estimation and double optical hardlimiters (2003)

This paper proposes a new channel interference cancellation technique using interference estimation and double optical hardlimiters (DHLs) for direct-detection optical code-division multiple-access systems. In the proposed system, when the output of the DHL is "0", the proposed system outputs "0". When the output of the DHL is "1", the proposed system reconstructs the interference and estimates whether the output "1" is owing to the interference or the transmitted signal. It is shown that the proposed system is effective to reduce the effects of the channel interference. Moreover, it is shown that the proposed system can improve the error floor of the systems with DHL.
Chemosensing of 1,4-dinitrobenzene using bisfluorene dendrimer distributed feedback lasers (2009)

We report the trace vapor detection of the molecule 1,4-dinitrobenzene, a model analyte for the explosive substance 2,4,6-trinitrotoluene, via fluoresence quenching of a first generation conjugated dendrimer containing a 2,2′-bis[9,9-di-n-hexylfluorene] core. We show that much greater sensitivity can be obtained by using the material as a surface emitting distributed feedback laser. We find that the slope efficiency of the laser is a convenient and sensitive indicator of the presence of the analyte. The slope efficiency decreases by a factor 50 in the presence of 1,4-dinitrobenzene.
Design of Low Voltage Low Power ADC for WSN Node (2013)

This paper presents a low power low voltage 7bit 16MS/s SAR ADC (successive approximation register analog-to-digital converter) for the application of ZigBee receiver. The proposed 7-bit ADC is designed and simulated in 180nm RF CMOS technology. Post simulation results show that at 1.0-V supply and 16 MS/s, the ADC achieves a SNDR (signal-to-noise-and-distortion ratio) and SFDR (Spurious Free Dynamic Range) are 43.6dB, 57.4dB respectively. The total power dissipation is 228μW, and it occupies a chip area of 0.525 mm 2 . It results in a figure-of-merit (FOM) of 0.11pJ/step.
Quantum Dot Photon Statistics Measured by Three-Dimensional Particle Tracking (2007)

We present an instrument for performing correlation spectroscopy on single fluorescent particles while tracking their Brownian motion in three dimensions using real-time feedback. By tracking CdSe/ZnS quantum dots in water (diffusion coefficient approximately 20 microm2/s), we make the first measurements of photon antibunching (at approximately 10 ns) on single fluorophores free in solution and find fluorescence lifetime heterogeneity within a quantum dot sample. In addition, we show that 2-mercaptoethanol suppresses short time-scale intermittency (1 ms to 1 s) in quantum dot fluorescence by reducing time spent in the off-state.
Personal exposure monitoring of PM 2.5 in indoor and outdoor microenvironments (2014)

Adverse health effects from exposure to air pollution are a global challenge and of widespread concern. Recent high ambient concentration episodes of air pollutants in European cities highlighted the dynamic nature of human exposure and the gaps in data and knowledge about exposure patterns. In order to support health impact assessment it is essential to develop a better understanding of individual exposure pathways in people's everyday lives by taking account of all environments in which people spend time. Here we describe the development, validation and results of an exposure method applied in a study conducted in Scotland. A low-cost particle counter based on light-scattering technology — the Dylos 1700 was used. Its performance was validated in comparison with equivalent instruments (TEOM-FDMS) at two national monitoring network sites (R2 = 0.9 at a rural background site, R2 = 0.7 at an urban background site). This validation also provided two functions to convert measured PNCs into calculated particle mass concentrations for direct comparison of concentrations with equivalent monitoring instruments and air quality limit values. This study also used contextual and time-based activity data to define six microenvironments (MEs) to assess everyday exposure of individuals to short-term PM2.5 concentrations. The Dylos was combined with a GPS receiver to track movement and exposure of individuals across the MEs. Seventeen volunteers collected 35 profiles. Profiles may have a different overall duration and structure with respect to times spent in different MEs and activities undertaken. Results indicate that due to the substantial variability across and between MEs, it is essential to measure near-complete exposure pathways to allow for a comprehensive assessment of the exposure risk a person encounters on a daily basis. Taking into account the information gained through personal exposure measurements, this work demonstrates the added value of data generated by the application of low-cost monitors.
Real-time 3D Motion Capture (1998)

We describe a real-time 3D computer vision system for detecting and tracking human movement and providing a person with control over the movement of a virtual puppet. Multiple cameras observe a person; silhouette analysis and template matching achieve real-time 3D estimation of human posture. A dynamics/kinematics model of human body and Kalman filter are utilized to help the tracking process as well as to interpolate some joint locations. All estimation and rendering processes run in real-time on a PC based system.
Magnetic detection of photogenerated currents in semiconductor wafers using superconducting quantum interference devices (1999)

A completely noninvasive method is presented for the investigation of semiconductor wafers with high spatial resolution utilizing a superconducting quantum interference device (SQUID) magnetometer system. The method is based on the detection of the magnetic field caused by photocurrents generated in the semiconductor sample using a sensitive SQUID magnetometer. The photocurrents arise when laser light with a photon energy exceeding the band gap of the semiconductor is focused onto the sample surface in a region of a doping gradient. The spatial resolution of this detection method is mainly determined by the size of the excitation focus of about 20 μm. We report on measurements of silicon wafers with small growth-related doping fluctuations.
Homologous piperazine-alcanols: chiral pool synthesis and pharmacological evaluation (2012)

Starting with the proteinogenic amino acids (S)-aspartate and (S)-glutamate the homologous piperazine-alcanols 3 and 4 were prepared in a five step synthesis. The diversity was introduced by N-1 alkylation of the piperazinediones 5 and 6 with various alkyl halides. Subsequent LiAlH4 reduction of the dioxopiperazine-esters 7 and 8 provided the alcohols 3 and 4. The ethanol derivatives 3 show similar σ1 affinity as the methanol derivatives 2, but increased selectivity over the σ2 subtype. The corresponding propanol derivatives 4 are considerably less potent. A benzyl or dimethylallyl residue at N-1 appears to be optimal for high σ1 affinity.
Induction of Suppression of Delayed Type Hypersensitivity to Herpes Simplex Virus by Epidermal Cells Exposed to UV-Irradiated Urocanic Acid <i>In Vivo</i> (1987)

Urocanic acid (UCA), the putative photoreceptor for ultraviolet radiation (UV)-induced suppression, undergoes a UV-dependent trans to cis isomerisation. Epidermal cells from mice painted with UCA, containing a known proportion of the cis-isomer, generate suppression of the delayed type hypersensitivity response to herpes simplex virus type 1 (HSV-1) when transferred to naive syngeneic recipients at the same time and site as infection with HSV-1. One T suppressor cell subset, of phenotype (Thy1+, L3T4+, Ly2-), is induced by the cis-UCA modified epidermal cell transfer. Flow cytometric analysis of the epidermal cells from skin treated with UV or cis-UCA indicates an overall reduction from normal in the number of cells expressing MHC Class II antigens, but no alteration in the number expressing I-J antigens.
Prevalence of suicide attempts in individuals with schizophrenia: a meta-analysis of observational studies (2019)

Suicide attempts are common in individuals with schizophrenia, especially those with an early age of onset and living in high-income countries and regions. Regular screening and effective preventive measures should be implemented as part of the clinical care.
Reaction of Rosmarinic Acid with Nitrite Ions in Acidic Conditions: Discovery of Nitro- and Dinitrorosmarinic Acids as New Anti-HIV-1 Agents (2008)

Rosmarinic acid was reacted with nitrite ions under acidic conditions to give 6'-nitro- and 6',6''-dinitrorosmarinic acids according to the reaction time. Both compounds were active as HIV-1 integrase inhibitors at the submicromolar level. They also inhibited the viral replication in MT-4 cells with modest and similar selectivity indexes. The nitration of rosmarinic acid strongly improves the anti-integrase inhibition and the antiviral activity without increasing the cellular toxicity.
Severe generalized glutathione reductase deficiency after antitumor chemotherapy with BCNU" [1,3-bis(chloroethyl)-1-nitrosourea]. (1977)

Perovskite solar cells attract a lot attention as alternative energy sources for the future energy market. With the remarkable lab-scale achievements, the investigations into a high-throughput large-scale production of perovskite devices are now on the agenda. The first step towards mass manufacturing should be a replacement of toxic solvents used in the manufacturing of perovskite layer. In this study, a non-toxic and up-scaling compatible solvent system is developed. The impact of the solvent properties on the perovskite crystallization kinetics has been systematically investigated, which is found to be crucial in controlling the surface coverage and layer crystallinity. By optimizing the processing conditions, a stabilized efficiency of 16.0% is achieved with the developed non-toxic solvent system.
Novel detection system of flow injection analysis (1). The existence of significant relation between secondary structure of DNA and sensitivity in signal detection. (1997)

Polymerase Chain Reaction (PCR) products was detected quantitatively using a flow injection type sensor, based on Surface Plasmon Resonance (SPR). We used asymmetric PCR to amplify the two kinds of products; their DNA lengths are different. This novel design permitted us not only to detect PCR products with high-sensitivity, but also to develop a rapid DNA detection system for the sense of the genetic pathogen.
RIBBON-1: Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Chemotherapy With or Without Bevacizumab for First-Line Treatment of Human Epidermal Growth Factor Receptor 2–Negative, Locally Recurrent or Metastatic Breast Cancer (2011)

The combination of BV with Cape, Tax, or Anthra improves clinical benefit in terms of increased PFS in first-line treatment of metastatic breast cancer, with a safety profile comparable to prior phase III studies.
Reversible optical computing circuits (1987)

Planar optical implementations of binary adders are developed using a three-port nonlinear interface device as the single computing primitive. The device is bit-conserving and both optically and logically reversible.
Time-dependent density-functional theory for open systems (2007)

With our proof of the holographic electron density theorem for time-dependent systems, a first-principles method for any open electronic system is established. By introducing the self-energy density functionals for the dissipative interactions between the reduced system and its environment, we develop a time-dependent density-functional theory formalism based on an equation of motion for the Kohn-Sham reduced single-electron density matrix of the reduced system. Two approximate schemes are proposed for the dissipative interactions, the complete second-order approximation and the wide-band limit approximation. A numerical method based on the wide-band limit approximation is subsequently developed and implemented to simulate the steady and transient current through various realistic molecular devices. Simulation results are presented and discussed.
Crosslinked Cationic Cotton via Ethoxylated Quaternaries (1988)

Ethoxylated quaternaries were found to be useful reactive additives for durable press finishing. Durable press fabrics with these quaternary grafts can be dyed subse quent to finishing, thus providing an attractive route to garment dyeable smooth drying fabrics. These glycol additives can be used as components of a finish to yield smooth drying cotton fabrics with enhanced strength retention.
Errata: Second-order statistics of laser-speckle patterns (1976)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. G. Miller, A. M. Schneiderman, and P. F. Kellen, "Errata: Second-order statistics of laser-speckle patterns," J. Opt. Soc. Am. 66, 79_1-79 (1976) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Melatonin and insomnia (1996)

The hypnotic action of melatonin 5 mg p.o. was explored in 15 subjects with psychophysiological insomnia in a double-blind controlled self-report questionnaire study. Melatonin or placebo was taken at 20.00 hours for a 1-week period in random order. Effects on sleep and wakefulness were monitored by visual analogue scale and structured interview. Bedtime, sleep onset time, estimated total sleep and wake time, as well as self-rated sleep quality, were not altered by melatonin, and estimates of next-day function did not change. The period of melatonin, treatment was retrospectively correctly identified by 8 of 15 subjects. Despite unchanged ratings of night sleep quality on the last night of each treatment, 7 of 15 subjects reported that sleep had subjectively improved to a minor extent in the week of active treatment. Side-effects attributed to melatonin included headache and an odd taste in the mouth. These data indicate that melatonin is probably of no clinical value in the management of psychophysiological insomnia.
10 kV, 120 A SiC half H-bridge power MOSFET modules suitable for high frequency, medium voltage applications (2011)

The majority carrier domain of power semiconductor devices has been extended to 10 kV with the advent of SiC MOSFETs and Schottky diodes. The devices exhibit excellent static and dynamic properties with encouraging preliminary reliability. Twenty-four MOSFETs and twelve Schottky diodes have been assembled in a 10 kV half H-bridge power module to increase the current handling capability to 120 A per switch without compromising the die-level characteristics. For the first time, a custom designed system (13.8 kV to 465/√3 V solid state power substation) has been successfully demonstrated with these state of the art SiC modules up to 855 kVA operation and 97% efficiency. Soft-switching at 20 kHz, the SiC enabled SSPS represents a 70% reduction in weight and 50% reduction in size when compared to a 60 Hz conventional, analog transformer.
Differential Inhibition of <i>Staphylococcus aureus </i>PBP2 by Glycopeptide Antibiotics (2005)

The glycopeptide antibiotics prevent maturation of the bacterial cell wall by binding to the terminal d-alanyl-d-alanine moiety of peptidoglycan precursors, thereby inhibiting the enzymes involved in the final stages of peptidoglycan synthesis. However, there are significant differences in the biological activity of particular glycopeptide derivatives that are not related to their affinity for d-Ala-d-Ala. We compare the ability of vancomycin and a set of clinically relevant glycopeptides to inhibit Staphylococcus aureus PBP2 (penicillin binding protein), the major transglycosylase in a clinically relevant pathogen, S. aureus. We report experiments suggesting that activity differences between glycopeptides against this organism reflect a combination of substrate binding and secondary interactions with key enzymes involved in peptidoglycan synthesis.
Fast and Robust High Dynamic Range Image Generation with Camera and Object Movement (2006)

High dynamic range (HDR) images play an impor-tant role in todays computer graphics: Typical ap-plications are the improved display of a photograph with a tone mapper and the relighting of a virtual object in a natural environment using an HDR en-vironment map. Generating an HDR image usually requires a sequence of photographs with different exposure times which are combined to a single im-age. In practice two problems occur when taking an image sequence: The camera is moving or ob-jects are moving during the sequence. This results in a blurry HDR image due to the camera move-ment and moving objects appear multiple times as ghost images in the combined image. In this paper,
“Clicked” fluoropolymer elastomers as robust materials for potential microfluidic device applications (2011)

We report the design and synthesis of a new perfluoropolyether-based material, which has liquid-like viscosity and can be cured into a tough, highly durable elastomer when “clicked” with selected tri-pod organic small molecules. This highly fluorinated elastomer exhibits remarkable resistance to a variety of organic solvents, water, heat and even harsh acidic and basic conditions. Whereas PDMS-based microfluidic devices are commonly used for aqueous based applications, their limited chemical resistance and high swellability in many common organic solvents make it unfeasible for microfluidic applications involving organic solvents and/or harsh conditions. With excellent chemical resistance and low swellability, our newly synthesized fluoro-elastomers will hopefully provide an alternative material for organic based microfluidic devices. Furthermore, the alkyne–azide “click” chemistry employed in curing not only provides high efficiency of synthesis and ease of device fabrication, but, more importantly, produces 1,2,3-triazole linkages that are very stable against harsh acidic or basic conditions. This work has great potential to expand microfluidics to a series of novel applications especially in organic and medicinal chemistry.