gebhart/patrepeval huggingface dataset:
Is exocrine pancreatic cancer a hormone-dependent tumor? A study of the existence of sex hormone receptors in normal and neoplastic pancreas. (1991)

The 5-year survival rate of patients with exocrine pancreatic cancer after surgery is less than 5%, in patients treated with radical surgery, with or without adjuvant therapy. It has been well documented clinically and experimentally that sex hormones influence the physiology of the exocrine pancreas. Hormone manipulation inhibits the growth of human pancreatic cancer in nude mice. Several nonrandomized studies have suggested the efficacy of antihormone therapy in the treatment of advanced pancreatic cancer. However, the existence of sex hormone receptors in exocrine pancreatic cancer has been a matter of controversy. This study was designed to investigate the presence of sex hormone receptors (estrogens, progesterone and androgens in normal pancreas and exocrine pancreatic cancer, using two different methods: immunohistochemistry and enzyme immunoassay. Twenty-eight biopsies of normal pancreas and 15 biopsies of exocrine pancreatic cancer were studied. Estrogen receptors and progesterone receptors were measured by enzyme immunoassay, using specific monoclonal antibodies. Androgen receptors were determined by radioligand assay. Sixteen biopsies of normal pancreas and 12 biopsies of exocrine pancreatic cancer were studied by immunohistochemistry. In exocrine pancreatic cancer we could not detect estrogen receptors or progesterone receptors, either by enzyme immunoassay or immunohistochemistry. Androgen receptors were always negative (less than 2 fm/mg). In the normal pancreas, 5 out of 28 cases showed increased levels of progesterone receptors (greater than 10 fm/mg) as measured by enzyme immunoassay. Immunohistochemistry revealed progesterone receptors in the pancreatic islets of 16 normal pancreases studied. Nuclear staining was observed in more than 70% of the cells. Estrogen receptors were always negative by immunohistochemistry and enzyme immunoassay in the normal pancreas.2+n
Perinatal Infection with Human Immunodeficiency Virus (1987)

INFANTS born to mothers infected with the human immunodeficiency virus (HIV) are at risk for exposure to HIV in utero, during delivery, and after birth in breast milk or through other close contact.1 2 3 4 The diagnosis of HIV infection in the offspring of an infected mother may be difficult. Mothers infected with HIV produce IgG antibodies; these are transferred to the fetus transplacentally, and cord blood is thus positive for antibody when tested by enzyme-linked immunosorbent assay (ELISA) or Western blot techniques. Because of their physiologically depressed immune response, newborns generally produce a less vigorous and more limited antibody response to . . .
The Image chip for high performance 3D rendering (1992)

The Image chip, which accelerates 3D rendering algorithms base on Bresenham's line drawing and Pineda's parallel polygon drawing algorithms, is discussed. With these algorithms, Image can directly draw lines, spans, and triangles in wireframe, hidden-line, and Gouraud-shading modes. Image also directly antialiases vectors or provides antialiasing information to enhance antialiasing of vectors or triangles. Image's operation, separation into layers to maximize performance and simplify the input and output interfaces, and support of advanced rendering effects such as Phong shading and texture mapping are described. The designs of Image's internal architecture, host interface, and memory interface are also described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hypertext Transfer Protocol (HTTP) over QUIC (2018)

The QUIC transport protocol has several features that are desirable in
a transport for HTTP, such as stream multiplexing, per-stream flow
control, and low-latency connection establishment. This document
describes a mapping of HTTP semantics over QUIC. This document also
identifies HTTP/2 features that are subsumed by QUIC, and describes
how HTTP/2 extensions can be ported to QUIC.
Antireflection coatings with Chebyshev or Butterworth response: design (1986)

Approximations are developed for the refractive indices of nonabsorbing layers with equal optical thickness producing an antireflection coating for a dielectric substrate that has a Chebyshev spectral response.
Short-Chain Fatty Acid Fermentation Products of Plant Fiber Affect Glucose Metabolism of Isolated Rat Hepatocytes (1984)

Short-chain fatty acids (SCFA) produced during fermentation of plant fibers and absorbed from the colon may affect hepatic glucose metabolism. We examined the effects of different fatty acids on rates of glucose production and glycolysis in isolated rat hepatocytes. Acetate, butyrate, and long-chain fatty acids significantly increased glucose production from lactate. However, propionate and valerate significantly decreased glucose production from lactate. Whereas 5 mM butyrate increased the incorporation of [14C]lactate into [14C]glucose by 80%, 5 mM propionate produced a 67% decrease. Glycolysis was significantly decreased by acetate, butyrate, and long-chain fatty acids. However, propionate and valerate significantly increased glycolysis. Thus propionate, which inhibits hepatic acetate metabolism, acts to increase glucose use and decrease glucose production. Plant fibers may influence hepatic glucose metabolism via their SCFA metabolites.
Cell Type‐specific Effects of the Neural Adhesion Molecules L1 and N‐CAM on Diverse Second Messenger Systems (1992)

We have previously shown that the neural adhesion molecules L1 and N-CAM influence second messenger systems when triggered with specific antibodies at the surface of the phaeochromocytoma PC12 cell line (Schuch et al., Neuron, 3, 13 - 20, 1989). To determine whether the two molecules are linked to the same intracellular signalling cascades, independent of the cell type expressing them, or whether different neural cell types respond with different signal transduction mechanisms, we have investigated the effects of antibodies to L1 and N-CAM, and the isolated molecules themselves, on second messenger systems in different neural cell types. We have investigated cultures of cerebellar and dorsal root ganglion neurons and transformed Schwann cells and related these results to those obtained with the PC12 cell line. Here we show that addition of L1 and N-CAM antibodies and the isolated molecules themselves elicit cell type-specific responses that can be modulated by the substrate on which the cells are maintained. Depending on the cell type, cells respond to the triggering of L1 and N-CAM with antibodies, or addition of the purified molecules, by either up-regulation or down-regulation of inositol phosphate turnover, by a rise in intracellular Ca2+ levels dependent on or independent of the opening of voltage-gated Ca2+ channels, or by an increase or decrease in intracellular pH. Moreover, cerebellar neurons expressing N-CAM respond to addition N-CAM, but not to N-CAM antibodies, in contrast to the other neural cell types studied, which respond to both triggers. Furthermore, cerebellar neurons were the only cells to show a rise in cAMP levels in response to any of the ligands tested. This stimulation of cAMP production by L1 antibodies depended on the cross-linking of L1 molecules at the cell surface, whereas the other responses did not depend on clustering of L1. Simultaneous addition of L1 and N-CAM antibodies either elicited an additive or more than additive effect on the intracellular responses which, for cerebellar neurons, depends on the substrate on which the cells are maintained. These observations indicate that L1 and N-CAM or their antibodies activate cell type-specific intracellular signalling systems and that the two molecules can act interdependently or independently of each other.
Si FinFET based 10nm technology with multi Vt gate stack for low power and high performance applications (2016)

10nm logic technology using Si FinFET is developed for low power and high performance applications. Power-speed gain of 27% compared to 14nm technology node was obtained using four key developments: 1) advanced gate stack engineering enabling 4 multi-Vt devices, 2) 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> generation Fin technology, 3) highly doped source/drain (S/D), and 4) contact resistance optimization. CVD liner for BEOL process was also applied for better metal fill capability. Finally yield of the smallest ever SRAM with 0.04um <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> SRAM bit-cell size was demonstrated.
Benzyl diethyl phosphite as a coke inhibitor during naphtha pyrolysis. tubular reactor studies (1993)

Abstract The effectiveness of benzyl diethyl phosphite as a coke inhibitor during naphtha pyrolysis was investigated in a tubular reactor at 1073 K and atmospheric pressure. Significant reduction in the coking rate was achieved by adding benzyl diethyl phosphite to the feed. The effect of toluene, methylcyclohexane, l‐octene and carbon disulfide on the rate of coke formation was also investigated. Toluene enhanced the rate of coke formation significantly, whereas with methylcyclohexane and l‐octene the increase was less appreciable. Carbon disulphide decreased the amount of coke deposited initially, but with increasing run time the asymptotic coking rates were found to be higher than for straight‐run naphtha. The yields of propylene, 1,3‐butadiene and butenes increased on addition of carbon disulphide.
A low profile UWB antenna for wearable applications: The tripod kettle antenna (TKA) (2013)

A new low profile ultra-wideband (UWB) antenna for wearable applications is presented.Its structure is derived from the quadripod kettle antenna (QKA) [1], and is called tripod kettle antenna (TKA).The proposed antenna is very well suited for wearable applications due to its miniature size and low profile.Moreover, the antenna is completely encapsulated in a Polydimethylsiloxane (PDMS) substrate enabling a certain level of flexibility and a good robustness against different external influences (e.g.different weather conditions).The TKA is a broadband antenna with 70% coverage of the fractional UWB bandwidth (Federal Communications Commission, FCC).The antenna has a polarization perpendicular to the body surface with a quasi-omnidirectional radiation pattern in the plane orthogonal to the polarization.An antenna prototype has been built and characterized, and measured results are in a good compliance with the simulations. Index Terms-Low profile and
TGF-β1 induces bone marrow reticulin fibrosis in hairy cell leukemia (2004)

The mechanisms that lead to reticulin fibrosis of bone marrow (BM) in hairy cell leukemia (HCL) are not fully understood. We therefore investigated the involvement of TGF-beta1, a potent fibrogenic cytokine, in this process. Immunoassays revealed that TGF-beta1 is present at higher concentrations in BM, serum, and plasma of HCL patients in comparison with healthy donors (P < 0.001). RT-PCR and immunofluorescence studies showed that TGF-beta1 is overexpressed at the mRNA and protein levels in peripheral blood, spleen, and BM mononuclear cells and that hairy cells (HCs) are the main source of TGF-beta1. Active TGF-beta1 correlated significantly with grades of BM fibrosis, infiltration with HCs, and serum procollagen type III aminoterminal propeptide (PIIINP). Ex vivo studies demonstrated that TGF-beta1 significantly enhances the production and deposition of reticulin and collagen fibers by BM fibroblasts. In addition, BM plasma of HCL patients increased the synthesis of type I and type III procollagens, the main components of reticulin fibers, at the mRNA and protein levels. This fibrogenic activity of BM plasma was abolished by neutralizing anti-TGF-beta1 antibodies. These results show, for the first time to our knowledge, that TGF-beta1 is highly expressed in HCs and is directly involved in the pathogenesis of BM reticulin fibrosis in HCL.
Powerful beneficial effects of macrophage colony-stimulating factor on  -amyloid deposition and cognitive impairment in Alzheimer's disease (2008)

Alzheimer's disease is a major cause of dementia in humans. The appearance of cognitive decline is linked to the overproduction of a short peptide called beta-amyloid (Abeta) in both soluble and aggregate forms. Here, we show that injecting macrophage colony-stimulating factor (M-CSF) to Swedish beta-amyloid precursor protein (APP(Swe))/PS1 transgenic mice, a well-documented model for Alzheimer's disease, on a weekly basis prior to the appearance of learning and memory deficits prevented cognitive loss. M-CSF also increased the number of microglia in the parenchyma and decreased the number of Abeta deposits. Senile plaques were smaller and less dense in the brain of M-CSF-treated mice compared to littermate controls treated with vehicle solution. Interestingly, a higher ratio of microglia internalized Abeta in the brain of M-CSF-treated animals and the phagocytosed peptides were located in the late endosomes and lysosomes. Less Abeta(40) and Abeta(42) monomers were also detected in the extracellular protein enriched fractions of M-CSF-treated transgenic mice when compared with vehicle controls. Finally, treating APP(Swe)/PS1 mice that were already demonstrating installed Abeta pathology stabilized the cognitive decline. Together these results provide compelling evidence that systemic M-CSF administration is a powerful treatment to stimulate bone marrow-derived microglia, degrade Abeta and prevent or improve the cognitive decline associated with Abeta burden in a mouse model of Alzheimer's disease.
Differential Instant Radiosity for mixed reality (2010)

In this paper we present a novel plausible realistic rendering method for mixed reality systems, which is useful for many real life application scenarios, like architecture, product visualization or edutainment. To allow virtual objects to seamlessly blend into the real environment, the real lighting conditions and the mutual illumination effects between real and virtual objects must be considered, while maintaining interactive frame rates (20-30fps). The most important such effects are indirect illumination and shadows cast between real and virtual objects. Our approach combines Instant Radiosity and Differential Rendering. In contrast to some previous solutions, we only need to render the scene once in order to find the mutual effects of virtual and real scenes. The dynamic real illumination is derived from the image stream of a fish-eye lens camera. We describe a new method to assign virtual point lights to multiple primary light sources, which can be real or virtual. We use imperfect shadow maps for calculating illumination from virtual point lights and have significantly improved their accuracy by taking the surface normal of a shadow caster into account. Temporal coherence is exploited to reduce flickering artifacts. Our results show that the presented method highly improves the illusion in mixed reality applications and significantly diminishes the artificial look of virtual objects superimposed onto real scenes.
The NAD<sup>+</sup>/NADH redox state in astrocytes: Independent control of the NAD<sup>+</sup> and NADH content (2011)

The intracellular redox state is established by several redox pairs, such as NAD(+) /NADH and NADP(+) /NADPH and glutathione. This redox state is a crucial determinant of cellular metabolism and function. Astrocytes are an important cell population contributing to brain metabolism and brain energy supply, so a careful control of these redox pairs is essential for proper brain function. Despite this, little is known about control of the NAD(+) and NADH content within the brain or in astrocytes. Therefore, we here analyzed the NAD(+) and NADH content of mouse tissue and cultured cortical astrocytes. The NAD(+) /NADH ratio increased in most tissues during development from newborn to adult mice. The basal redox ratio of cultured astrocytes was about 3.8 and similar to the redox ratio of the cortex of newborn mice. Although the NADH content of these cells was highly sensitive to the concentration of energy substrates and to modulation of energy metabolism, the NAD(+) content was surprisingly constant under these conditions. In contrast, application of nicotine amide or nicotinamide mononucleotide, which are precursors for NAD(+) biosynthesis, slowly increased NAD(+) content while leaving NADH levels unaffected. Finally, inhibiting the NAD(+) -degrading enzyme poly-(ADP-ribose)-polymerase increased NAD(+) content slightly without affecting NADH levels, whereas inhibition of sirtuins had no effect. These results indicate that, in addition to converting NAD(+) to NADH and vice versa during redox reactions, the content of both partners of this redox pair is additionally controlled by other mechanisms.
The combination of an electrospray ion source and an electrostatic storage ring for lifetime and spectroscopy experiments on biomolecules (2002)

An electrospray ion source has been coupled to an accelerator that injects ions into an electrostatic heavy-ion storage ring. Since the dc ion current produced by electrospray ionization is low (∼106 ions/s), ions are accumulated in a cylindrical ion trap filled with a helium buffer gas. The ions are collisionally damped in the buffer gas and confined to the central trap region by a rf field. Extraction from the trap occurs within a few microseconds and after acceleration through 22 kV, the ions of interest are selected by a magnet according to their mass to charge ratio. The ion bunch is subsequently injected into the ring. Both positive and negative ions have been stored, with masses ranging over 3 orders of magnitude (∼102–104 Da). From a pickup signal in the ring, the number of ions in a bunch is estimated to be of the order of 103–104 when the accumulation time is 0.1 s. Our first measurements show that we can store a sufficient number of ions to study the decay of metastable ions and to determine relative destruction cross sections. The technique could be useful to probe conformers differing only in size. Furthermore, our setup can be used for spectroscopic measurements of the ion-photon interaction such as the excitation of [Cytochrome c+17H]17+ protein ions with 532 nm photons.
One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy (2012)

To access useful heterocycles in medicinal chemistry such as pyridazinones, dihydropyrimidinones, and dihydropyrimidinthiones, a “green” mild and highly efficient one-pot triple cascade was developed involving a Claisen–decarboxylation, electrophilic reaction, and subsequent heterocyclization. In addition, indazoles and benzofurans could also be constructed via a double cascade. To develop the cascade process, a direct Claisen–decarboxylation reaction was firstly optimized. This reaction can then couple with electrophilic reactions including alkylation, Michael addition or aldol reaction to enable the preparation of various aryl ketones in a one-pot fashion.
Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain (2013)

Chronic pain affects billions of lives globally and is a major public health problem in the United States. However, pain management is still a challenging task due to a lack of understanding of the fundamental mechanisms of pain. In the past decades transient receptor potential (TRP) channels have been identified as molecular sensors of tissue damage and inflammation. Activation/sensitization of TRP channels in peripheral nociceptors produces neurogenic inflammation and contributes to both somatic and visceral pain. Pharmacological and genetic studies have affirmed the role of TRP channels in multiple forms of inflammatory and neuropathic pain. Thus pain-evoking TRP channels emerge as promising therapeutic targets for a wide variety of pain and inflammatory conditions.
Some basic features of the beam emittance (2003)

Some general features of the beam emittance are discussed. The significance of rms values for the emittance calculation and emittance measurements is emphasized and it is shown that the emittance of a beam is not necessarily constant in a drift space.
Carbohydrase hydrolysis of canola to enhance oil extraction with hexane (1988)

Abstract Hydrolysis of three canola cultivars with carbohydrase reduced oil extraction time and increased oil yield. The optimum pretreatment before hexane extraction of oil was flaking, autoclaving, adjustment to 30% seed moisture including 0.12% enzyme concentration (g enzyme protein/100 g flakes), and incubation for 12 hr at 50 C, followed by drying to 4% moisture. Hexane extraction was enhanced by grinding the flakes. The relative order of enzyme efficiency in enhancement of oil extraction was mixed activity enzyme >β‐glucanase>pectinase>hemicellulase>cellulase.
Loss of heterozygosity on chromosome 1q in human breast cancer. (1989)

Cytogenetic markers involving the long arm of chromosome 1 are the most frequently observed karyotypic changes seen in breast cancer. Based on cytogenetic data, we have used polymorphic DNA markers to search for allelic losses at this chromosome region among 48 breast carcinomas. For SPTA1, allelic losses were seen in 6 of 26 (23%) informative carcinomas, while 3 of 13 (23%) and 5 of 19 (26%) informative patients showed losses at AT3 and D1S53, respectively. The background frequency of allelic loss was obtained from data using 3 other loci on the 1q arm and 2 on the p arm of chromosome 1. With these markers, only 6 of 62 informative patients (8%) showed an allelic loss, with the range being 0-13%. The allelic losses seen on 1q, which were found in 9 carcinomas, comprised an overlapping set; the common region deleted was approximately 26 centimorgans on the q arm of chromosome 1 (bands q23-32 between AT3 and D1S53). These results suggest that inactivation of a gene(s) located on 1q23-32 might contribute to the genesis of breast cancer.
Regulation of Leishmania populations within the host. I. the variable course of Leishmania donovani infections in mice. (1977)

The course of infection with Leishmania donovani was followed in seven strains of laboratory mice with measurement of the liver parasite burdens over 20 weeks. The acute parasite population growth rate varied greatly between, but not within, strains. Four strains were relatively resistant with less than an eight-fold increase while the three acutely susceptible strains showed over an eight-fold increase in the first month. Thereafter, one initially susceptible strain showed a dramatic fall in parasite numbers with histological liver damage while another strain maintained an immense parasite load for up to 2 years involving mononuclear phagocytes throughout the body. The system provides a model for studying genetic control of resistance to intracellular infection and the range of responses is compared with human leprosy and cutaneous leishmaniasis.