gebhart/patrepeval huggingface dataset:
Inhibition of clot lysis and decreased binding of tissue-type plasminogen activator as a consequence of clot retraction (1992)

Tissue-type plasminogen activator (t-PA) is less active in vivo and in vitro against clots that are enriched in platelets, even at therapeutic concentrations. The release of radioactivity from 125I-fibrin-labeled clots was decreased by 47% 6 hours after the addition of t-PA 400 U/mL when formed in platelet-rich versus platelet-poor plasma. This difference was not due to the release of plasminogen activator inhibitor-1 (PAI-1) by platelets. Thus, the fibrinolytic activity of t- PA in the supernatant was similar in the two preparations and fibrin autography demonstrated only a minor degree of t-PA-PAI-1 complex formation. Furthermore, a similar platelet-dependent reduction in clot lysis was seen with a t-PA mutant resistant to inhibition by PAI-1. The reduction in t-PA activity correlated with a decrease in t-PA binding to platelet-enriched clot (60% +/- 3% v platelet-poor clot, n = 5). This reduction in binding was also shown using t-PA treated with the chloromethylketone, D-Phe-Pro-Arg-CH2Cl (PPACK) (36% +/- 13%, n = 3), and with S478A, a mutant t-PA in which the active site serine at position 478 has been substituted by alanine (43% +/- 6%, n = 3). In contrast, fixed platelets and platelet supernatants had no effect on the binding or lytic activity of t-PA. Pretreatment with cytochalasin D 1 mumol/L, which inhibits clot retraction, also abolished the platelet- induced inhibition of lysis and t-PA binding by platelets. These data suggest that platelets inhibit clot lysis at therapeutic concentrations of t-PA as a consequence of clot retraction and decreased access of fibrinolytic proteins.
Preparation and Conductivity Measurements of SiS2 ‐ Li2 S  ‐ LiBr Lithium Ion Conductive Glasses (1985)

Etude de l'influence d'un dopage par LiBr sur la conductivite et l'etendue de la vitrification du systeme SiS 2 −Li 2 S, en faisant varier la concentration molaire de LiBr en maintenant constant le rapport molaire SiS 2 /Li 2 S a 1/1
TRACKING VEHICLE IN GSM NETWORK TO SUPPORT INTELLIGENT TRANSPORTATION SYSTEMS (2012)

Abstract. The penetration of GSM capable devices is very high, especially in Europe. To exploit the potential of turning these mobile devices into dynamic data acquisition nodes that provides valuable data for Intelligent Transportation Systems (ITS), position information is needed. The paper describes the basic operation principles of the GSM system and provides an overview on the existing methods for deriving location data in the network. A novel positioning solution is presented that rely on handover (HO) zone measurements; the zone geometry properties are also discussed. A new concept of HO zone sequence recognition is introduced that involves application of Probabilistic Deterministic Finite State Automata (PDFA). Both the potential commercial applications and the use of the derived position data in ITS is discussed for tracking vehicles and monitoring traffic flow. As a practical cutting edge example, the integration possibility of the technology in the SafeTRIP platform (developed in an EC FP7 project) is presented.
Association of SWAP-70 with the B cell antigen receptor complex (2000)

SWAP-70 is a component of an enzyme complex that recombines Ig switch regions in vitro. We report here the cloning of the human cDNA and its B lymphocyte-specific expression. Although its sequence contains three nuclear localization signals, in small resting B cells, SWAP-70 is mainly found in the cytoplasm. On stimulation, SWAP-70 translocates to the nucleus. In activated, class-switching B cell cultures, it is associated with membrane IgG, but not IgM. The membrane Ig association requires a functional pleckstrin homology domain and is controlled by the C terminus. We suggest that SWAP-70 is involved not only in nuclear events but also in signaling in B cell activation.
Differential transcriptional activation by v-myb and c-myb in animal cells and Saccharomyces cerevisiae. (1993)

The v-myb oncogene and its cellular homolog c-myb encode sequence-specific DNA-binding proteins which regulate transcription from promoters containing Myb-binding sites in animal cells. We have developed a Saccharomyces cerevisiae system to assay transcriptional activation by v-Myb and c-Myb. In yeast strains containing integrated reporter genes, activation was strictly dependent upon both the Myb DNA-binding domain and the Myb recognition element. BAS1, an endogenous Myb-related yeast protein, was not required for transactivation by animal Myb proteins and by itself had no detectable effect on a Myb reporter gene. Deletion analyses demonstrated that a domain of v-Myb C terminal to the previously mapped Myb transcriptional activation domain was required for transactivation in animal cells but not in S. cerevisiae. The same domain is also required for the efficient transformation of myeloid cells by v-Myb. In contrast to results in animal cells, in S. cerevisiae the full-length c-Myb was a much stronger transactivator than a protein bearing the oncogenic N- and C-terminal truncations of v-Myb. These results imply that negative regulation of c-Myb by its own termini requires an additional animal cell protein or small molecule that is not present in S. cerevisiae.
Development of a Polymerase Chain Reaction Test to Confirm <i>Mycobacterium Avium</i> Subsp. <i>Paratuberculosis</i> in Culture (2004)

A polymerase chain reaction (PCR) assay for confirmation of Mycobacterium avium subsp. paratuberculosis was developed using the primer set derived from ISMav2. The PCR product was 494 base pairs (bp) and could be digested with ClaI, which produced 311- and 183-bp fragments. No amplification of 494-bp DNA fragment was detected from DNA of other Mycobacterium spp., including Mycobacterium avium complex, other bacteria, including Escherichia coli, Pseudomonas aeruginosa, Actinobacillus pleuropneumoniae, Leptospira interrogans serovar pomona, Corynebacterium pseudotuberculosis, Salmonella typhimurium, Borrelia burgdorferi, and Staphylococcus aureus, and the Scedosporium sp. This PCR assay could detect 5-8 genome equivalents.
AA amyloidosis due to chronic oxalate arthritis and vasculitis in a patient with secondary oxalosis after jejunoileal bypass surgery (2008)

We report a case of a woman with secondary oxalosis after jejunoileal bypass surgery for obesity, who presented with oxalate stone disease and renal insufficiency requiring dialysis. Thirty years after surgery, longstanding osteoarticular symptoms were recognized as oxalate arthritis. Eventually, she also developed oxalate vasculitis, which improved with corticoid treatment and intensification of dialysis. Work-up for kidney transplantation revealed AA amyloidosis on gastric and colonic biopsies. Since no other cause of chronic inflammation could be identified, it was concluded that the amyloidosis was secondary to oxalate arthritis and vasculitis. To our knowledge, this is the first report on this association.
Detection of reactive free radicals derived from nucleosides by liquid chromatography coupled to tandem mass spectrometry of DMPO spin trapping adducts (2006)

In this study, reactive free radicals derived from several nucleosides were spin trapped by 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and then detected by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC/ESI-MS/MS). This method provides a specific detection of spin trapping adducts derived from nucleosides with a very high sensitivity: quantities as low as 0.5 picomoles of spin trapping adducts corresponding to concentrations of 2.5 10(-8) mol . L(-1) were detected. Different spin trapping adducts were characterized by HPLC/ESI-MS/MS in three well-known systems producing free radicals photochemically: the photolysis of 5-halo-2'-deoxyuridines, the photolysis of 5-thiophenylmethyl-2'-deoxyuridine and the photolysis of thymidine with menadione bisulfite as a photosensitizer. A new radical photoreactivity of uridine derivatives was also detected by this method both at the nucleoside and at the RNA level, showing that the method is also relevant for studying spin trapping adducts derived from DNA and RNA strands.
Effect of water potential on sol–gel transition and intermolecular interaction of gelatin near the transition temperature (2003)

The sol-gel transition of gelatin, measured by thermal analysis and viscosity measurement, was analyzed in terms of the change in hydration state of polymer molecules. A new thermodynamic model was proposed in which the effect of water potential is explicitly taken into account for the evaluation of the free energy change in the sol-gel transition process. Because of the large number of water molecules involved and the small free energy change in the transition process, the contribution of water activity, a(W), was proved to be not negligible in the sol-gel transition process in solutions containing such low-molecular cosolutes as sugars, glycerol, urea, and formamide. The gel-stabilization effect of sugars and glycerol was linear with a(W), which seemed consistent with the contribution of water potential in the proposed model. The different stabilization effect among sugars and glycerol was explained by the difference in solvent ordering, which affects hydrophobic interaction among protein molecules. The gel-destabilization effect of urea and formamide could be explained only by the direct binding of them to protein molecules through hydrogen bonding. On the contrary, the polymer-polymer interaction, measured by the viscosity analysis, in polyethyleneglycol and dextran solutions was not sensitive to the change in a(W), suggesting that no substantial change in hydration state with a(W) occurred in these polymer solutions.
Nepheline Syenite‐Talc Mixtures as a Flux in Low‐Ternperature Vitrified Bodies (1950)

A study was made of the use of nepheline syenite‐talc combinations as a flux for producing vitrified bodies at low temperatures. It was found that a mixture of 85% nepheline syenite and 15% talc had a lower deformation temperature than either of these materials alone, indicating a eutectic in the system. Bodies were compounded by adding nepheline syenite and talc, in the ratio found to be the most fusible, to clays and flint. Bodies were developed that had less than 0.3% absorption in the firing range cone 02 to cone 2. These bodies had good color. Their modulus of rupture values ranged from 7000 to 10,000 lb. per sq. in.
Maximum Allowed Solvent Accessibilites of Residues in Proteins (2013)

The relative solvent accessibility (RSA) of a residue in a protein measures the extent of burial or exposure of that residue in the 3D structure. RSA is frequently used to describe a protein's biophysical or evolutionary properties. To calculate RSA, a residue's solvent accessibility (ASA) needs to be normalized by a suitable reference value for the given amino acid; several normalization scales have previously been proposed. However, these scales do not provide tight upper bounds on ASA values frequently observed in empirical crystal structures. Instead, they underestimate the largest allowed ASA values, by up to 20%. As a result, many empirical crystal structures contain residues that seem to have RSA values in excess of one. Here, we derive a new normalization scale that does provide a tight upper bound on observed ASA values. We pursue two complementary strategies, one based on extensive analysis of empirical structures and one based on systematic enumeration of biophysically allowed tripeptides. Both approaches yield congruent results that consistently exceed published values. We conclude that previously published ASA normalization values were too small, primarily because the conformations that maximize ASA had not been correctly identified. As an application of our results, we show that empirically derived hydrophobicity scales are sensitive to accurate RSA calculation, and we derive new hydrophobicity scales that show increased correlation with experimentally measured scales.
Towards Subband-Based Speech Recognition (1996)

Publication in the conference proceedings of EUSIPCO, Trieste, Italy, 1996
A parameter tracking servo for adaptive control systems (1959)

This paper describes one very general approach to the design of adaptive control systems. The particular systems considered are process adaptive. The dynamic characteristics of the physical process are determined by the parameter tracking servo. The parameters thus determined are used to program the process' controller. The parameter tracking servo is a closed loop self-adjusting system. It consists of the following elements; 1) the physical process, 2) the learning model, 3) the adjusting mechanism. The learning model and the physical process are subjected to the same input signals. Their outputs are compared and the resultant error is fed to the adjusting mechanism where some function of this error is used to adjust the parameters of the learning model. The mechanism will continuously track the parameters of the physical process as they change with time in some unknown manner. The adjusting mechanism operates on an approximation to the method of steepest descent. These equations are derived for a first order process and the over-all systems is analyzed. The equations describing the tracking servo's operation are both non-linear and non-autonamous. System response as a function of input signal, gain, and error function are described analytically. Experimental results are included to demonstrate the validity of the analytic solutions.
A new query processing technique for XML based on signature (2001)

XML is represented as a tree and the query as a regular path expression. The query is evaluated by traversing each node of the tree. Several indexes are proposed for regular path expressions. In same cases these indexes may not cover all possible paths because of storage requirements. We propose a signature-based query optimization technique to minimize the number of nodes retrieved from the database when the indexes cannot be used. The signature is a hint attached to each node, and is used to prune unnecessary sub-trees as early as possible when traversing nodes. For this goal, we propose a signature-based DOM(s-DOM) as a storage model and a signature-based query executor(s-NFA). Our experimental results show that the signature method outperforms the original.
Reversible dimerization of avian pancreatic polypeptide (1980)

The dimerization of avian pancreatic polypeptide (PP) was studied by large-zone gel chromatography using integral boundary analysis. The association constant has been determined as a function of temperature and pH. The dimerization is endothermic and entropically driven, which suggests hydrophobic interactions, and is enhanced with increasing pH. Analysis of the pH dependence indicates the involvement of ionizable groups. with pKa values of 4.5-5.5. In the avian PP molecule, there are six groups which are potentially titratable in this pH range. A comparison of the amino acid sequence of avian PP with that of the bovine and canine homologues, which also exhibit pH-dependent dimerization [Noelken, M.E., Chang, P.J. & Kimmel, J.R. (1980) Biochemistry (preceding paper in this issue)], shows that they have three carboxylate and two guanidinium groups in common. It is suggested that salt linkages involving these groups participate in dimerization. In the avian peptide, histidine-34 may also be involved.
Design of a Weakly-Coupled Ring-Core FMF and Demonstration of 6-mode 10-km IM/DD Transmission (2018)

We design and fabricate a weakly-coupled ring-core 6-mode fiber with a minimum Δneff of 1.49×10-3, based on which 6-mode 10-km MDM transmission with OOK modulation and direct detection is experimentally demonstrated.
Retinal Nerve Fiber Layer Thickness is Decreased in Patients With Hematologic Malignancy (2015)

The RNFL defect was frequently observed, and the RNFL was thinner in severe anemic patients with hematologic malignancy. These results suggest that chronic anemia may be a factor of RNFL loss.
Effect of Lyxoflavin on Growth of Baby Pigs Fed a Synthetic Diet (1952)

1. The addition of 4 μg of synthetic 1-lyxoflavin per g of dry matter consumed in 3 experiments significantly increased the rate of gain and efficiency of feed utilization of baby pigs fed a low fat basal ration including 0.01% protamine. 2. Using a differential assay procedure for lyxoflavin it was found that approximately 67% of the lyxoflavin intake was excreted in the urine. 3. In vitro studies of heart and liver tissue did not indicate any conversion of riboflavin into lyxoflavin.
The Influence of Met Receptor Level on HGF-Induced Glycolytic Reprogramming in Head and Neck Squamous Cell Carcinoma (2020)

Head and neck squamous cell carcinoma (HNSCC) is known to overexpress a variety of receptor tyrosine kinases, such as the HGF receptor Met. Like other malignancies, HNSCC involves a mutual interaction between the tumor cells and surrounding tissues and cells. We hypothesized that activation of HGF/Met signaling in HNSCC influences glucose metabolism and therefore substantially changes the tumor microenvironment. To determine the effect of HGF, we submitted three established HNSCC cell lines to mRNA sequencing. Dynamic changes in glucose metabolism were measured in real time by an extracellular flux analyzer. As expected, the cell lines exhibited different levels of Met and responded differently to HGF stimulation. As confirmed by mRNA sequencing, the level of Met expression was associated with the number of upregulated HGF-dependent genes. Overall, Met stimulation by HGF leads to increased glycolysis, presumably mediated by higher expression of three key enzymes of glycolysis. These effects appear to be stronger in Met<sup>high</sup>-expressing HNSCC cells. Collectively, our data support the hypothesized role of HGF/Met signaling in metabolic reprogramming of HNSCC.
Rectilinear block placement using B*-trees (2003)

Due to the layout complexity in modern VLSI designs, integrated circuit blocks may not be rectangular. However, literature on general rectilinear block placement is still quite limited. In this article, we present approaches for handling the placement for arbitrarily shaped rectilinear blocks using B*-trees [Chang et al. 2000]. We derive the feasibility conditions of B*-trees to guide the placement of rectilinear blocks. Experimental results show that our algorithm achieves optimal or near-optimal block placement for benchmarks with various shaped blocks.
Parametric imaging of myocardial blood flow with 15O-water and PET using the basis function method. (2005)

The basis function method produces parametric images of MBF, perfusable tissue fraction, and Va with 15O-water and PET. These images will be useful in detecting regional myocardial perfusion abnormalities.
Genetic disruption of <i>PPAR</i> δ decreases the tumorigenicity of human colon cancer cells (2001)

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that have been implicated in a variety of biologic processes. The PPARdelta isotype was recently proposed as a downstream target of the adenomatous polyposis coli (APC)/beta-catenin pathway in colorectal carcinogenesis. To evaluate its role in tumorigenesis, a PPARdelta null cell line was created by targeted homologous recombination. When inoculated as xenografts in nude mice, PPARdelta -/- cells exhibited a decreased ability to form tumors compared with PPARdelta +/- and wild-type controls. These data suggest that suppression of PPARdelta expression contributes to the growth-inhibitory effects of the APC tumor suppressor.
Device and Piezoelectric Characteristics of Pb(Mn 1/3 Sb 2/3 )O₃-PZT Ceramics for Piezoelectric Transformer (1999)

In the (Pb 1-x M x )[(Mn 1/3 Sb 2/3 ) 0.05 Zr y Ti 0.95?y ]O₃ system, where M=Ca and Sr, the piezoelectric properties were evaluated to examine the possibility of application to piezoelectric transformer. A Rosen-type piezoelectric transformer was formed, then the electrical properties of voltage step-up ratio, frequency characteristics etc. were analysed. The morphotropic phase boundary was determined to be y=0.475 in Pb[(Mn 1/3 Sb 2/3 ) 0.05 Zr y Ti 0.95?y ]O₃ system, and the piezoelectric properties of this composition was k p =0.59, Q m =1600 and e r =1150. Moreover, when 1-2 ㏖% of Sr are substituted, enhanced piezoelectric properties of k p =0.61, Q m =1600 and ? r =1400 were shown. The temperature rising (ΔT) of a piezoelectric transformer with Pb[(Mn 1/3 Sb 2/3 ) 0.05 Zr 0.475 Ti 0.475 )]O₃ composition was 10℃, and the voltage step-up ratio was 500 when the output voltage was 4000 V, whereas the △T was below 3℃ and the resonant frequency variation (△f r ) as a function of load resistance was below 5% when the output voltage was 2000 V. These characteristics are superior to the properties of materials, which were substituted by Ca or without substitution.
Exploiting group communication for reliable high volume data distribution (2002)

The design and implementation of a protocol to provide reliable and efficient distribution of large quantities of data to many hosts on a local area network or internetwork is described. By exploiting the one-to-many transmission capabilities of multicast and broadcast, it is possible to transmit data to multiple hosts simultaneously, using less bandwidth and thus obtaining greater efficiency than repeated unicasting. Although performance measurements indicate the superiority of multicast, we dynamically select from available transmission modes so as to maximize efficiency and throughput while providing reliable delivery of data to all hosts. Our results demonstrate that file-distribution programs based on this protocol can benefit from a linear speed-up over TCP-based programs such as rdist.
Finding faces in photographs (2002)

Two new schemes are presented for finding human faces in a photograph. The first scheme approximates the unknown distributions of the face and the face-like manifolds wing higher order statistics (HOS). An HOS-based data clustering algorithm is also proposed. In the second scheme, the face to non-face and non-face to face transitions are learnt using a hidden Markov model (HMM). The HMM parameters are estimated corresponding to a given photograph and the faces are located by examining the optimal state sequence of the HMM. Experimental results are presented on the performance of both the schemes.
The Autonomous Detection of Clock Problems in Satellite Timekeeping Systems (1999)

Military satellite communications (milsatcom) systems require precise timekeeping in order to take advantage of spread-spectrum communication techniques. Though the level of precise timekeeping in milsatcom is typically not as stringent as that in satellite navigation, milsatcom nevertheless poses its own unique timekeeping problems. Specifically, milsatcom timekeeping must be robust, with the ability to autonomously detect and correct timekeeping problems during protracted periods when the ground control station is either not available or burdened with other pressing tasks. Here, we consider the ability of three different space-segment timekeeping subsystems to autonomously detect the failure of a single satellite clock and to then take appropriate action to remedy the situation. These systems include a Master/Slave system, an Ensembling system, and a Kalman-Filter system. Employing Monte Carlo simulation, we consider four types of 'soft' clock failure: a time-jump failure, a frequency-jump failure, a failure arising from a sudden change in the clock's frequency aging rate, and a failure arising from an abrupt increase in the clock's random-walk frequency noise. Our results demonstrate that the performance of the three space-segment timekeeping subsystems can be enhanced by adding general 'clock failure rules' to the basic algorithms that are associated with each system. Once in place, these rules provide for robust, autonomous space-segment timekeeping,even in the presence of satellite clock failures.