gebhart/patrepeval huggingface dataset:
Transglutaminase-catalysed Formation of Coenzymatically Active NAD<sup>+</sup>Analog • Casein Conjugates (1982)

Journal Article Transglutaminase-catalysed Formation of Coenzymatically Active NAD+ Analog • Casein Conjugates Get access Masaaki Yoshikawa, Masaaki Yoshikawa Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Masaaki Goto, Masaaki Goto Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Koji Ikura, Koji Ikura Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Ryuzo Sasaki, Ryuzo Sasaki Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideo Chiba Hideo Chiba Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 46, Issue 1, 1 January 1982, Pages 207–213, https://doi.org/10.1080/00021369.1982.10865026 Published: 01 January 1982 Article history Received: 06 July 1981 Published: 01 January 1982
Laminin molecular domains which alter metastasis in a murine model. (1984)

Human and murine tumor cells contain cell surface receptors for the basement membrane glycoprotein laminin. Since a biologic role for the receptor had not previously been demonstrated, we explored the possibility that the laminin receptor may be involved in hematogenous metastases formation. Preincubation of metastatic murine melanoma cells with syngeneic whole laminin followed by tail vein injection increased tumor cell retention in the lung and strongly stimulated metastases formation. The domain of the laminin molecule responsible for stimulating metastases was identified. Laminin is a cross-shaped molecule with three short arms and one long arm. All arms have globular end regions. Purified protease-derived fragments of laminin were prepared which (a) lacked only the long arm of the molecule (alpha fragment) or, (b) lacked both the long arm and the globular end regions of the short arms (C1 fragment). Both types of fragments contained the laminin receptor binding region. The fragments had opposite effects on metastases. The alpha fragment stimulated metastases formation to the same extent as whole laminin. In contrast, the C1 fragment greatly reduced or abolished metastases formation in a dose-dependent manner. The C1 fragment also inhibited tumor cell attachment to whole amnion basement membrane in vitro. We conclude that intact globular end regions on the short arms (but not the long arm) of the cell surface receptor-bound laminin molecule are necessary for stimulating metastases by the intravenous route.
Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency (2013)

Non-synonymous mutations affecting both alleles of PCSK1 (proprotein convertase 1/3) are associated with obesity and impaired prohormone processing. We report a proband who was compound heterozygous for a maternally inherited frameshift mutation and a paternally inherited 474kb deletion that encompasses PCSK1, representing a novel genetic mechanism underlying this phenotype. Although pro-vasopressin is not a known physiological substrate of PCSK1, the development of central diabetes insipidus in this proband suggests that PCSK1 deficiency can be associated with impaired osmoregulation.
Alkyl halides, super hydrogen production and the pathogenesis of pneumatosis cystoides coli (1997)

Chloral and trichloroethylene are alkyl halides chemically similar to chloroform, a potent inhibitor of H2 consumption by methanogens and acetogens. These bacteria are the most important H2-consuming species in the colon. It is postulated that exposure to these alkyl halides increases net H2 production, which sets the scene for "counterperfusion supersaturation" and the formation of gas cysts. In recent times, very low prescribing rates for chloral have caused primary pneumatosis cystoides to become extremely rare. As with primary pneumatosis, secondary pneumatosis cystoides, which occurs if there is small bowel bacterial overgrowth distal to a proximally located gut obstruction, is predicted by counterperfusion supersaturation. "Inherent unsaturation" due to metabolism of O2 is a safety factor, which could explain why gas bubbles do not form more often in tissue with high H2 tension.
Morphology of Elastomeric Alloys (1991)

Abstract The field of thermoplastic elastomers has shown an explosive growth with the successful commercialization of elastomeric alloys (EAs) in 1981, based on the original work of Coran, Das, and Patel on dynamic vulcanization and the discovery of preferred cure system by Abdou-Sabet and Fath. These discoveries have led to the development of commercial products having true elastomeric properties while maintaining excellent thermoplastic processing. The success of EAs in the marketplace has led to the introduction of new products by Monsanto and others at a rate of 60 products per year in the last half of the eighties. Elastomeric alloys have been characterized as compositions containing rubber particulate domains approximately 1–2 µm in diameter in a matrix of thermoplastic resin. Such dispersed phase morphology has not been widely accepted, especially when it came to explaining the true elastomeric properties of the soft elastomeric products, i.e. 64 and 55 Shore A hardness products. Interaction among the rubber particles leading to a network of vulcanized elastomer phase that gave the appearance of two continuous networks has been proposed. In this paper, the morphology of EPDM/polypropylene elastomeric alloys is examined with some detail, and evidence leading to dispersed phase morphology is provided. There are several variables to such an investigation which can be grouped under the following headings: 1. Molecular weight of EPDM and polypropylene (PP). 2. Ratio of EPDM to PP. 3. Crosslinked or uncrosslinked blend. 4. Degree of crosslinking. 5. Type of crosslinks. 6. Typical and commercial products. It is not the subject of this paper to review the morphology of different binary polymer blends, which have been extensively covered in the literature. It can be concluded that a variety of morphologies can be obtained, however, depending on the mixing conditions, polymer ratios, relative surface energies of the polymer pair, and viscosities and molecular weights of the two polymers. In this study, the mixing conditions were kept similar as much as possible to eliminate the possibility of morphological changes as a function of the applied mixing intensity as influenced by shear rate, mixing time, and temperature.
Cellular Targeting for Cochlear Gene Therapy (2009)

Gene therapy has considerable potential for the treatment of disorders of the inner ear. Many forms of inherited hearing loss have now been linked to specific locations in the genome, and for many of these the genes and specific mutations involved have been identified. This information provides the basis for therapy based on genetic approaches. However, a major obstacle to gene therapy is the targeting of therapy to the cells and the times that are required. The inner ear is a very complex organ, involving dozens of cell types that must function in a coordinated manner to result in the formation of the ear, and in hearing. Mutations that result in hearing loss can affect virtually any of these cells. Moreover, the genes involved are active during particular times, some for only brief periods of time. In order to be effective, gene therapy must be delivered to the appropriate cells, and at the appropriate times. In many cases, it must also be restricted to these cells and times. This requires methods with which to target gene therapy in space and time. Cell-specific gene promoters offer the opportunity to direct gene therapy to a desired cell type. Moreover, conditional promoters allow gene expression to be turned off and on at desired times. Theoretically, these technologies offer a mechanism by which to deliver gene therapy to any cell, at any given time. This chapter will examine the potential for such targeting to deliver gene therapy to the inner ear in a precisely controlled manner.
Experimental models of gastric ulceration and injury (1988)

There are inumerable experimental models of gastric mucosal epithelial injury. Many of these currently in wide use can be regarded as unphysiological and severe, rarely encountered in humans. An analysis of more physiological and simple models indicates that little is known of the events that ultimately cause cellular death, even in simple and easily controllable systems. A review of acceptable measures of gastric mucosal injury is presented. It is suggested that studies of subtle physiological injuries at the cellular level are more likely to yield meaningful insights into the causation of gastric mucosal ulceration.
A New Approach to the Blocking of Alloreactive T Cell-Mediated Graft-versus-Host Disease by In Vivo Administration of Anti-CXCR3 Neutralizing Antibody (2008)

Chemokines and chemokine receptors play critical roles in directing the migration of alloreactive donor T cells into graft-vs-host disease (GVHD) target organs. However, blockade of GVHD by antagonist Ab against chemokine receptors remains an elusive goal. Using a mouse model of human GVHD, we demonstrate that in vivo administration of anti-CXCR3 Ab for 21 days (long-term), but not for 7 days (short-term), inhibits alloreactive CD8(+) T cell-mediated GVHD. During a graft-vs-host reaction, infused donor CD8(+) T cells generate two subsets of potent inducers of GVHD: CXCR3(+)CD8(+) and CXCR3(-)CD8(+) T cells. Compared with CXCR3(+)CD8(+) T cells, CXCR3(-)CD8(+) T cells produce less granzyme B, Fas ligand, IFN-gamma, and TNF-alpha. Interestingly, stimulation with either dendritic cells or IL-2 induces a dynamic conversion between CXCR3(+)CD8(+) and CXCR3(-)CD8(+) T cells. Short-term anti-CXCR3 Ab treatment inhibits only CXCR3(+)CD8(+) T cell-mediated GVHD, but not the disease induced by CXCR3(-)CD8(+) T cells. Prolonged in vivo administration of anti-CXCR3 Ab significantly reduces the infiltration of alloreactive CD8(+) T cells into GVHD target organs and inhibits GVHD mediated by either CXCR3(+)CD8(+) or CXCR3(-)CD8(+) T cells. Thus, we have established a novel and effective approach with the potential to give rise to new clinical methods for preventing and treating GVHD after allogeneic hematopoietic stem cell transplantation.
Constant Infusions vs. Intermittent Doses of Gentamicin Against Pseudomonas aeruginosa in Vitro (1982)

Comparative studies were performed in vitro to test the advocated superiority of infusion over intermittent injection of aminoglycosides. Pseudomonas aeruginosa was exposed to constant and to continuously decreasing (simulating in vivo kinetics) concentrations of gentamicin. In comparing the effect with similar area-under-the-concentration-vs.-time curves, a substantial difference in killing and regrowth could not be demonstrated. Regrowth occurred only when the gentamicin concentration had continuously decreased below one fourth of the minimal inhibitory concentration for greater than 2 hr. Exposure of P. aeruginosa to gentamicin for 30 min was followed by persistent suppression of bacterial regrowth for 1.4-1.9 hr. Thus, intermittent exposure of P. aeruginosa to gentamicin is as effective as constant exposure in vitro. The demonstrated persistent postantibiotic effect might cover in part the periods between intermittent doses of gentamicin in vivo as well as in vitro.
Audible Noise Reduction Method in IPMSM Position Sensorless Control Based on High-Frequency Current Injection (2015)

Methods for sensorless control involving the injection of a high-frequency signal into the low-speed range of an interior permanent-magnet synchronous motor (IPMSM) have been proposed. However, audible noise is a concern for these methods. We propose a method to reduce the audible noise due to a high-frequency current by minimizing the injection-signal amplitude suitable for IPMSM driving states.
Stochastic last-mile delivery problems with time constraints (2015)

<p>When a package is shipped, the customer often requires the delivery to be made within a particular time window or by a deadline. However, meeting such time requirements is difficult, and delivery companies may not always know ahead of time which customers will need a delivery. In this thesis, we present models and solution approaches for two stochastic last-mile delivery problems in which customers have delivery time constraints and customer presence is known in advance only according to a probability distribution. Our solutions can help reduce the operational costs of delivery while improving customer service.</p> <p>The first problem is the probabilistic traveling salesman problem with time windows (PTSPTW). In the PTSPTW, customers have both a time window and a probability of needing a delivery on any given day. The objective is to find a pre-planned route with an expected minimum cost. We present computational results that characterize the PTSPTW solutions. We provide insights for practitioners on when solving the PTSPTW is beneficial compared to solving the deterministic analogue of the problem.</p> <p>The second problem is the same-day delivery problem (SDDP). The SDDP is a dynamic and stochastic pick-up and delivery problem. In the SDDP, customers make delivery requests throughout the day and vehicles are dispatched from a warehouse or brick and mortar store to serve the requests. Associated with each request is a request deadline or time window. In order to make better-informed decisions, our solution approach incorporates information about future requests into routing decisions by using a sample scenario planning approach with a consensus function. We also introduce an analytical result that identifies when it is beneficial for vehicles to wait at the depot. We present a wide range of computational experiments that demonstrate the value of our approaches.</p>
Knock Detector System Controlling Turbocharger Boost Pressure (1980)

<div class="htmlview paragraph">In order to improve fuel economy and available power, a knock detector system has been developed which controls the maximum charge pressure in the Saab 2-litre Otto Cycle Turbo engine.</div> <div class="htmlview paragraph">Compared to ignition retard knock control, the charge pressure control offers advantages in tolerance to variations in fuel octane number, full throttle fuel economy, hot spot auto ignition control, exhaust gas temperature and sensitivity to electrical noise and interference.</div> <div class="htmlview paragraph">Further, the system allows a significant temporary increase in available engine power when accelerating in normal traffic conditions.</div> <div class="htmlview paragraph">The turbocharger wastegate setting for maximum charge pressure is achieved through an integrated electronic system. The charge pressure knock control system is to a great extent “fail-safe”.</div>
Regulation of Myeloid Cell Function through the CD200 Receptor (2006)

Myeloid cells play pivotal roles in chronic inflammatory diseases through their broad proinflammatory, destructive, and remodeling capacities. CD200 is widely expressed on a variety of cell types, while the recently identified CD200R is expressed on myeloid cells and T cells. CD200 deletion in vivo results in myeloid cell dysregulation and enhanced susceptibility to autoimmune inflammation, suggesting that the CD200-CD200R interaction is involved in immune suppression. We demonstrate in this study that CD200R agonists suppress mouse and human myeloid cell function in vitro, and also define a dose relationship between receptor expression and cellular inhibition. IFN-gamma- and IL-17-stimulated cytokine secretion from mouse peritoneal macrophages was inhibited by CD200R engagement. Inhibitory effects were not universal, as LPS-stimulated responses were unaffected. Inhibition of U937 cell cytokine production correlated with CD200R expression levels, and inhibition was only observed in low CD200R expressing cells, if the CD200R agonists were further cross-linked. Tetanus toxoid-induced human PBMC IL-5 and IL-13 secretion was inhibited by CD200R agonists. This inhibition was dependent upon cross-linking the CD200R on monocytes, but not on cross-linking the CD200R on CD4+ T cells. In all, we provide direct evidence that the CD200-CD200R interaction controls monocyte/macrophage function in both murine and human systems, further supporting the potential clinical application of CD200R agonists for the treatment of chronic inflammatory diseases.
Bandwidth-efficient continuous media streaming through optimal multiplexing (1999)

article Bandwidth-efficient continuous media streaming through optimal multiplexing Share on Authors: Wei Zhao Mobile Computing and Multimedia Lab, Department of Computer Science, University of Maryland, College Park, MD Mobile Computing and Multimedia Lab, Department of Computer Science, University of Maryland, College Park, MDView Profile , Satish K. Tripathi Bourns College of Engineering, University of California, Riverside, CA Bourns College of Engineering, University of California, Riverside, CAView Profile Authors Info & Claims ACM SIGMETRICS Performance Evaluation ReviewVolume 27Issue 1June 1999 pp 13–22https://doi.org/10.1145/301464.301476Online:01 May 1999Publication History 12citation530DownloadsMetricsTotal Citations12Total Downloads530Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Representing and comparing shapes using shape polynomials (2003)

The problem of multiresolution 2-D and 3-D shape representation is addressed. Shape is defined as a probability measure with compact support. Both object representations, typically sets of curves and/or surface patches, and observations, sets of scattered data, can be represented in this way. Global properties of shapes are defined as expectations (statistical averages) of certain functions. In particular, the moments of the shapes are global properties. To any shape S and every integer d>0 is associated a shape polynomial of degree 2d, whose coefficients are functions of the moments of S. These polynomials are related to the shape S in an affine-invariant way. They yield small values near S and large values far away, and their level sets approximate S. The shape polynomials define two distances between shapes. As asymmetric measures how well one shape fits as a subset of another one; a symmetric version indicates how equal two shapes are. The evaluation of these distance measures is determined by a sequence of computationally very fast matrix operations. The distance measures are used for recognition and positioning of objects in occluded environments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Commercialisation autrement ? Le cas du cacao dans la filière " bio - équitable " en Equateur (2004)

Le cacao fait partie des produits de base, dont les zones de production sont situees dans les pays du Sud et la consommation dans les pays du Nord. Le mecanisme de fixation du prix du cacao est base sur un prix de reference qui est celui de la Bourse. Depuis le debut des annees 1990, on assiste a d'importants changements dans les filieres d'approvisionnement, qui n'ont pas echappe au phenomene de globalisation dans l'agro-alimentaire. Les faits les plus marquants sont: la perte d'influence des caisses de stabilisation dans les pays africains et une segmentation des metiers. De grands groupes de broyage pour la fabrication de produits semi elabores, souvent decentralises dans les principaux pays producteurs, sont apparus. Cet article demontre comment il est possible, au sein d'une entreprise ayant une politique de developpement, de commercialiser du cacao de maniere rentable, tout en garantissant par contrat sur le long terme de meilleures conditions aux differents acteurs de la filiere dans les pays producteurs et en ayant une politique de respect de l'environnement. L'evaluation des couts montre qu'il semble effectivement possible de commercialiser du cacao differencie avec plus d'equite, tout en restant competitif et dans le cadre d'un developpement durable. (Resume d'auteur)
Nickel catalysis in halogen exchange with aryl and vinylic halides (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNickel catalysis in halogen exchange with aryl and vinylic halidesT. T. Tsou and J. K. KochiCite this: J. Org. Chem. 1980, 45, 10, 1930–1937Publication Date (Print):May 1, 1980Publication History Published online1 May 2002Published inissue 1 May 1980https://pubs.acs.org/doi/10.1021/jo01298a035https://doi.org/10.1021/jo01298a035research-articleACS PublicationsRequest reuse permissionsArticle Views1198Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Low voltage SC circuit design with low -V/sub t/ MOSFETs (2002)

In this paper, low threshold voltage (V/sub t/) "natural" transistors, available in some n/sup +//p/sup +/ dual poly gate CMOS/BiCMOS processes, are proposed for low voltage switched capacitor circuit design. The impact of the subthreshold off-current of these low V/sub t/ devices on the performance of analog switched-capacitor (SC) circuits is analyzed. Methods for reducing the subthreshold off-current in analog switches are discussed and two new switch topologies (series transmission gate and composite switch) addressing this problem are presented.