gebhart/patrepeval huggingface dataset:
Determination of Pepsin-Susceptible and Pepsin-Resistant Epitopes in Native and Heat-Treated Peanut Allergen Ara h 1 (2008)

This study was aimed at the determination of the pepsin-susceptible and pepsin-resistant epitopes in native and heat-treated Ara h 1, a major allergen from peanuts. Both the oligomeric structure and the trimeric structure of the allergen were investigated. Under the in vitro conditions applied, oligomeric Ara h 1, either unheated or preheated, was hydrolyzed by pepsin at a lower rate than trimeric Ara h 1. Peptides with relatively high molecular masses were shown to be able to bind IgE, whereas peptides with lower molecular masses (<2 kDa) did not. In these latter fractions, fragments of 15 previously published epitopes of mature Ara h 1 were identified. As a result, these epitopes are not likely responsible for the induction of systemic food allergic reactions to peanuts. Using sequential chymotrypsin digestion, the pepsin-resistant IgE-binding peptides were deduced to contain the previously identified intact epitopes EDWRRPSHQQ (amino acids 50-59) and PRKIRPEG (amino acids 60-67). The presence of four additional earlier published intact epitopes (covering amino acids 6-13, 14-21, 24-31, and 40-47) on the pepsin-resistant peptides could be neither deduced nor ruled out. The two deduced and four possible pepsin-resistant epitopes are all situated in the N-terminal part of Ara h 1, which does not show homology with other vicilin proteins. Consequently, this unique N-terminal part of Ara h 1 is proposed to be responsible for the allergen's ability to induce systemic allergic reactions.
The Failure of Solanezumab — How the FDA Saved Taxpayers Billions (2017)

The failure of solanezumab offers a window into the U.S. drug regulatory system, particularly in the context of the 21st Century Cures Act and the national debate about the role of the FDA. The solanezumab story is an important case of a regulatory system that worked.
Determinants of the Cost of Health Services Used by Veterans With HIV (2011)

Patients receiving combination ART had higher medication costs but lower acute hospital cost. Poor control of HIV was associated with higher cost. The cost of psychiatric, substance abuse, rehabilitation, and long-term care and medications other than ART, often overlooked in HIV studies, was substantial.
40.4: Optimization of Light‐Valve Mirrors (1998)

Abstract A mirror structure for reflective Si based light valves was fabricated using chemical mechanical polishing and a thin 150 nm Al(Cu)/Ti mirror to minimize hillock formation. The use of chemical‐mechanical polishing planarization resulted in only a 1% loss in reflectivity from topography under the mirrors. The reflectivity for pixel sizes from 7.5–40 μm and 0.7 or 0.5 μm gaps were measured and the performance of TN LC pixels with different sizes and inversion methods are reported.
Segmentation of Color Textures Using K-Means Cluster Based Wavelet Image Fusion (2010)

This paper develops a new method for cluster segmentation of color texture image. At first, a color texture image has been decomposed three sub-bands that R (red), G (green), B (blue) channel. Second, each sub-bands channel has been decomposed by discrete wavelet transform (DWT) to the same resolution. Third, fusion operation is performed on the transformed images according to PCA- based (Principal Component Analysis) weighted average rule to choose the reconstructed coefficients. Then all the decomposed sub-bands images are reconstructed using inverse discrete wavelet transform (IDWT) that becoming a fusion image. Finally, k-means cluster segmentation algorithm has been applied for this fusion image, the segmentation results has been obtained. A number of experiments are performed to demonstrate the efficacy of the proposed method.
Elderly Homeless in the UK: Lessons from Abroad (2011)

Issues around elderly homelessness have received increased attention as elderly homelessness numbers have increased. There has been significant policy innovation in social services in the United Kingdom over recent years. Last year, I was able to visit a number of UK organisations to learn about their experiences and approaches to elderly homelessness.
Force impedance control of a robot manipulator using a Neuro-Fuzzy controller (2011)

This article addresses the problem of enabling a robot manipulator to interact with the environment using the concept of impedance control. As the performance of the Position-Based Impedance Control is highly dependent on the accuracy of the position controller first a time-varying integral plus proportional-derivative controller is applied to the system which is capable of both regulating and tracking of input signals. The proposed impedance controller is used in a task including an interrupted trajectory tracking to check the ability of the Position-Based Impedance Control in tracking and regulating of the position and the force. To enable the impedance controller to track a desired force a Neuro-Fuzzy controller is proposed in the presence of unknown environment dynamic. Results obtained from various tests demonstrate the feasibility and effectiveness of the proposed strategy.
Homogeneous Green's functions as a dictionary for wavefield reconstruction (2014)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2014Homogeneous Green's functions as a dictionary for wavefield reconstructionAuthors: Paolo Terenghi*Paolo Terenghi*PGShttps://doi.org/10.1190/segam2014-1212.1 SectionsSupplemental MaterialAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Abstract Techniques for wavefield interpolation, extrapolation and regularization often rely on general-purpose dictionaries originating in the discipline of signal or image processing. However, the linearity of the Helmholtz equation suggests that a dictionary composed of homogeneous Green's functions may be specifically suitable for the reconstruction of the acoustic wavefields relevant to seismic exploration. Through such dictionary, data can be linearly mapped into a dual domain interpreted as an equivalent source distribution. The theoretical argument behind this mapping operation is constructed from first principles in this document. The scheme is then applied to the interpolation of a set of simple synthetic data. Keywords: interpolation, migration, scattering, wave equation, reconstructionPermalink: https://doi.org/10.1190/segam2014-1212.1FiguresReferencesRelatedDetailsCited byWavefield reconstruction using a Stolt-based asymptote and apex shifted hyperbolic Radon transformAmr Ibrahim, Mauricio D. Sacchi, and Paolo Terenghi19 August 2015 SEG Technical Program Expanded Abstracts 2014ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2014 Pages: 5183 publication data© 2014 Published in electronic format with permission by the Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 05 Aug 2014 CITATION INFORMATION Paolo Terenghi*, (2014), "Homogeneous Green's functions as a dictionary for wavefield reconstruction," SEG Technical Program Expanded Abstracts : 3627-3631. https://doi.org/10.1190/segam2014-1212.1 Plain-Language Summary Keywordsinterpolationmigrationscatteringwave equationreconstructionPDF DownloadLoading ...
The effects of recombinant human DNase on neutrophil elastase activity and interleukin-8 levels in the sputum of patients with cystic fibrosis (1996)

In cystic fibrosis (CF), neutrophil-dominated airway inflammation results in high levels of neutrophil elastase (NE). Some of these proteases are sequestered by the large amounts of deoxyribonucleic acid (DNA) present in purulent sputum. Recombinant human deoxyribonuclease (rhDNase), a new treatment in CF, depolymerizes DNA. Our concerns were that this might release proteases bound to DNA, which could be potentially harmful. The in vitro and in vivo effects of rhDNase on NE and interleukin-8 (IL-8) were evaluated. The acute effects of rhDNase were evaluated in CF patients during the first 6 days of treatment. Medium-term effects were evaluated in stable CF patients observed in rhDNase over 6 months. Sputum samples were collected at regular intervals and NE activity was measured by a fluorimetric assay and IL-8 with a radioimmunoassay. In vitro addition of rhDNase resulted in a twofold increase in protease activity and this was reflected in an acute transient rise on initiation of treatment with rhDNase. Medium-term treatment was associated with a decline in NE activity and IL-8. These in vivo results are encouraging, since the increase in protease activity was transient and the trend over 6 months was a reduction in both inflammatory markers.
Phylogenetic analyses and comparative genomics of vitamin B6 (pyridoxine) and pyridoxal phosphate biosynthesis pathways. (2001)

Vitamin B6 in its active form pyridoxal phosphate is an essential coenzyme of many diverse enzymes. Biochemistry, enzymology and genetics of de novo vitamin B6 biosynthesis have been primarily investigated in Escherichia coli. Database searches revealed that the key enzymes involved in ring closure of the aromatic pyridoxin ring (PdxA; PdxJ) are present mainly in genomes of bacteria constituting the gamma subdivision of proteobacteria. The distribution of DXS, a transketolase-like enzyme involved in vitamin B6 biosynthesis as well as in thiamine and isoprenoid biosynthesis and the distribution of vitamin B6 modifying enzymes (PdxH: oxidase; PdxK: kinase) was also analyzed. These enzymes are also present in the genomes of animals. Two recent papers (Ehrenshaft et al., 1999, Proc. Natl. Acad. Sci. USA. 96: 9374-9378; Osmani et al., 1999, J. Biol. Chem. 274: 23565-23569) show the involvement of an extremely conserved protein (a member of the UPF0019 or SNZ family) found in all three domains of life (bacteria, archaea, eukarya) in an alternative vitamin B6 biosynthesis pathway. Members of this family were previously identified as a stationary phase inducible protein in yeast, as an ethylene responsible protein in plants and in a marine sponge, as a singlet oxygen resistance protein in Cercospora nicotianae and as a cumene hydroperoxide and H2O2 inducible protein in Bacillus subtilis. In yeast, the SNZ protein interacts with another protein called SNO which also represents a member of a highly conserved protein family (called UPF0030 or SNO family). Phylogenetic trees for the DXS, PdxA, PdxJ, PdxH, PdxK, SNZ and SNO protein families are presented and possible implications of the two different vitamin B6 biosynthesis pathways in cellular metabolism are discussed. A radically different view of bacterial evolution (Gupta, 2000, Crit. Rev. Microbiol. 26: 111-131) which proposes a linear rather than a treelike evolutionary relationship between procaryotic species indicates that the gamma subdivision of proteobacteria represents the most recently evolved bacterial lineage. This proposal might help to explain why the PdxA/PdxJ pathway is largely restricted to this subdivision.
Flexible Microfluidic Circuit With Embedded In-plane Valve (2007)

Recent developments in Microfluidic systems have demonstrated many potential applications related to biology, chemistry and medical sciences. Fluidic manipulation with precise volume control is a basic function in these systems, and microvalves play an important role in control and delivery of the fluid sample. One of the key issues in such valve design is to make large membrane deflections compared to the channel dimension. This thesis reports a flexible microfluidic chip with embedded in-plane valves for fluid manipulation. Silicone elastomer (Polydimethylsiloxane - PDMS) is one of the most suitable materials to fabricate microvalve membranes, because of its low Young's modulus, excellent sealing property and rapid prototyping procedures. The proposed in-plane control valve utilizes pneumatic pressure source to squeeze the channel and restrict the flow through channel. These in-plane valves can be fabricated in a single layer with a plane top covering layer, hence reduces the multiple layers and alignment issues related to layer stacking. The experimental results show a membrane deflection of 25m with an applied pressure of 70psi. The prototype valves have a leakage ratio ranging between 0.4 and 0.2. These valves can be used for transportation of continuous and discrete volume flow.
Effect of nanosilica on the properties of polyester‐based polyurethane (2003)

Abstract Polyester‐based polyurethanes with embedded nanosilica particles were prepared. The viscosity of polyester resins without and with nanosilica was determined by rheoviscometry. The morphology and mechanical and optical properties of the polyurethane coatings were studied intensively with a transmission electron microscope, a pendulum hardness tester, a scanning probe microscope, an Instron testing machine, an abrader and an ultraviolet–visible spectrophotometer. The viscosity of the polyester resins increased as the nanosilica content increased. Nanosilica could basically be dispersed into the polyester and its polyurethane on a nanoscale. The addition of a small amount of nanosilica increased the hardness, abrasion resistance, and tensile properties of the polymer films. However, these mechanical properties could be worsened at higher nanosilica contents. The ultraviolet–visible spectra showed that the absorbance and reflection of ultraviolet–visible light by the polyurethane films increased as the nano‐SiO 2 content increased, especially at wavelengths of 290–400 nm. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 189–193, 2003
The Carbonation of Organoalkali Compounds (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Carbonation of Organoalkali CompoundsHenry Gilman and H. A. PacevitzCite this: J. Am. Chem. Soc. 1940, 62, 5, 1301–1302Publication Date (Print):May 1, 1940Publication History Published online1 May 2002Published inissue 1 May 1940https://pubs.acs.org/doi/10.1021/ja01862a502https://doi.org/10.1021/ja01862a502research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Formation of three-dimensional structure in proteins. I. Rapid nonenzymic reactivation of reduced lysozyme (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of three-dimensional structure in proteins. I. Rapid nonenzymic reactivation of reduced lysozymeDonald B. Wetlaufer and V. P. SaxenaCite this: Biochemistry 1970, 9, 25, 5015–5023Publication Date (Print):December 8, 1970Publication History Published online1 May 2002Published inissue 8 December 1970https://pubs.acs.org/doi/10.1021/bi00827a028https://doi.org/10.1021/bi00827a028research-articleACS PublicationsRequest reuse permissionsArticle Views697Altmetric-Citations308LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Eye Movement Desensitization and Reprocessing: Basic Principles, Protocols, and Procedures (1995)

Preface. Background. Adaptive Information Processing: The Model as a Working Hypothesis. Components of EMDR Treatment and Basic Treatment Effects. Phase One: Client History. Phases Two and Three: Preparation and Assessment. Phases Four to Seven: Desensitization, Installation, Body Scan, and Closure. Working with Abreaction and Blocks. Phase Eight: Re-evaluation and the Use of the EMDR Standard Three-Pronged Protocol. Protocols and Procedures for Special Situations. The Cognitive Interweave: A Proactive Strategy for Working with Challenging Clients. Selected Populations. Theory, Research, and Clinical Implications. Appendices: A. Clinical Aids. B. Client Safety. C. EMDR Resources.
In situ compatibilization of maleated thermoplastic starch/polyester melt‐blends by reactive extrusion (2008)

Abstract This article concerns the utilization of maleated thermoplastic starch (MTPS) in the reactive extrusion melt‐blending with poly(butylene adipate‐ co ‐terephthalate) (PBAT) in blown film applications. First, MTPS was prepared from cornstarch with glycerol (plasticizer) and maleic anhydride (MA; esterification agent). MTPS was then melt‐blended with PBAT in a subsequent downstream extrusion operation. The effects of both polyester and MA contents were studied on the physicochemical parameters of melt‐blends. For high polyester fractions (>60 wt%), PBAT‐ g ‐MTPS graft copolymers were obtained through transesterification reactions. They were promoted by the MA‐derived acidic moieties grafted onto the starch backbone as shown by selective Soxhlet extraction experiments and FTIR analyses. At lower polyester content, no significant reaction occurred more likely due to an inversion in the phase morphology between both components. Tensile properties of PBAT‐ g ‐MTPS graft copolymer containing 70 wt% polyester were much higher as the TPS/PBAT melt‐blend modified with MA. This can be explained by a finer morphology of the dispersed phase in the continuous PBAT matrix, and an increased interfacial area for the grafting reaction as attested by morphological studies. POLYM. ENG. SCI., 2008. © 2008 Society of Plastics Engineers.
Importance of bacteriophages in fermentation processes (1989)

Abstract Any bacterial strain can be infected by virulent phages or harbour one or more prophages. Therefore, bacteria‐phage interactions are to be regarded as fundamental properties of bacteria. In current industrial fermentation processes phages can be advantageously employed for the identification of bacterial production strains (phage typing). In some cases phages are involved in the production of enzymes and special substances. The fundamental importance of phages in any technical fermentation process, however, is based on the peculiarities of their obligately parasitic life cycle. The propagation of phages in fermentation processes can cause complete (or at least partial) lysis of the production strains and, consequently, serious disturbances in the production process and considerable economic losses. The phage problem in the fermentation industry has not yet been completely solved. For the protection of technical processes against virulent phages five measures are discussed: phage‐protected sterile fermentation, employment of alternative cultures, employment of phage‐resistant mutants, employment of phage inhibitors, and employment of immobilized bacterial cells. The problem of the protection of bacterial production strains from prophage induction is more difficult and practically unsolved. Two possibilities to minimize the process risk due to temperate phages, the elimination of inducing factors during the fermentation process, and the selection of production strains which are difficult to induce, are discussed.
Stool Microbiota and Vaccine Responses of Infants (2014)

Bifidobacterium predominance may enhance thymic development and responses to both oral and parenteral vaccines early in infancy, whereas deviation from this pattern, resulting in greater bacterial diversity, may cause systemic inflammation (neutrophilia) and lower vaccine responses. Vaccine responsiveness may be improved by promoting intestinal bifidobacteria and minimizing dysbiosis early in infancy.
Synthetic Routes to 3-Pyrrolidinol (1983)

Abstract Short, convenient routes to 3-pyrrolidinol are described.
Simulation of friction variation in hot strip rolling by 3D rigid plastic finite element method (2003)

In both rolling theory and practice, the important factor that must be considered is friction on the surface of the roll-strip. In order to improve the accuracy of on-line controlling models for hot strip rolling, in this paper, the rigid plastic finite element method is employed, considering constant friction, friction variation and mixed friction models to simulate this strip rolling. The results of simulation, such as rolling pressure and forward slip, taking into account the friction variation with suitable models in the roll bite are in good agreement with the experimental values. The modelling of friction variation with suitable models and mixed friction in the roll bite is stable and applicable, which can improve the accuracy of on-line control models.
High responsivity a-Si:H bottom-electrodemetal-semiconductor-metal photodetector (BMSM-PD) (1996)

A novel simple bottom-electrode metal-semiconductor-metal photodetector (BMSM-PD) with an i-a-Si:H barrier layer and a phosphorus-doped n-a-Si:H light-absorbing layer was used to improve the responsivity of MSM-PD. At a bias of 10 V and an He-Ne laser incident power of 10 µW, the obtained n-a-Si:H BMSM-PD had a high responsivity of 10 A/W, a low dark current density of 2.35 pA/µm2, and a spectral response peaked at 605 nm.
Review of Hydrogels and Aerogels Containing Nanocellulose (2017)

Naturally derived cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs) are emerging nanomaterials that display high strength, high surface area, and tunable surface chemistry, allowing for controlled interactions with polymers, nanoparticles, small molecules, and biological materials. Industrial production of nanocelluloses is increasing rapidly with several companies already producing on the tons-per-day scale, intensifying the quest for viable products across many sectors. While the hydrophilicity of the nanocellulose interface has posed a challenge to the use of CNCs and CNFs as reinforcing agents in conventional plastics, it is a significant benefit for creating reinforced or structured hydrogel composites (or, when dried, aerogels) exhibiting both mechanical reinforcement and a host of other desirable properties. In this context, this Review describes the quickly growing field of hydrogels and aerogels incorporating nanocelluloses; over 200 references are summarized in comprehensive tables covering the chemistry, preparation, properties, and applications of "nanocellulose-only" and "nanocellulose-containing" gels. Physical and chemical cross-linking strategies, postmodification steps, and routes to control gel structure are discussed, along with key developments and ongoing challenges in the field. Nanocellulose hydrogels and aerogels show great promise in a wide range of biomedical, energy storage, construction, separations, cosmetic, and food applications.