gebhart/patrepeval huggingface dataset:
High-dimensional regression with noisy and missing data: Provable guarantees with nonconvexity (2011)

Although the standard formulations of prediction problems involve fully-observed and noiseless data drawn in an i.i.d. manner, many applications involve noisy and/or missing data, possibly involving dependence, as well. We study these issues in the context of high-dimensional sparse linear regression, and propose novel estimators for the cases of noisy, missing and/or dependent data. Many standard approaches to noisy or missing data, such as those using the EM algorithm, lead to optimization problems that are inherently nonconvex, and it is difficult to establish theoretical guarantees on practical algorithms. While our approach also involves optimizing nonconvex programs, we are able to both analyze the statistical error associated with any global optimum, and more surprisingly, to prove that a simple algorithm based on projected gradient descent will converge in polynomial time to a small neighborhood of the set of all global minimizers. On the statistical side, we provide nonasymptotic bounds that hold with high probability for the cases of noisy, missing and/or dependent data. On the computational side, we prove that under the same types of conditions required for statistical consistency, the projected gradient descent algorithm is guaranteed to converge at a geometric rate to a near-global minimizer. We illustrate these theoretical predictions with simulations, showing close agreement with the predicted scalings.
Microbial attachment and feed digestion in the rumen (1994)

Direct microscopic examination of the rumen and its contents shows microbial populations largely attached to feed particles in the digesta. Most feeds contain a surface layer that is resistant to attachment and therefore to digestion. Infiltration of these recalcitrant epidermal layers through damage sites or through focused enzymatic attack is essential for initiation of the digestive process. Proliferation of primary colonizing cells produces glycocalyx-enclosed microcolonies. Secondary colonizers from the ruminal fluid associate with microcolonies, resulting in the formation of multispecies microbial biofilms. These metabolically related organisms associate with their preferred substrates and produce the myriad of enzymes necessary for the digestion of chemically and structurally complex plant tissues. Upon accessing the internal, enzyme-susceptible tissues, microbial "digestive consortia" attach to a variety of nutrients, including protein, cellulose, and starch and digest insoluble feed materials from the inside out. Substances that prevent microbial attachment or promote detachment (e.g., condensed tannins, methylcellulose) can completely inhibit cellulose digestion. As the microbial consortium matures and adapts to a particular type of feed, it becomes inherently stable and its participant microorganisms are notoriously difficult to manipulate due to the impenetrable nature of biofilms. Properties of feed that place constraints on microbial attachment and biofilm formation can have a profound effect on both the rate and extent of feed digestion in the rumen. Developments in feed processing (i.e., chemical and physical), plant breeding, and genetic engineering (both of ruminal microorganisms and plants) that overcome these constraints through the promotion of microbial attachment and biofilm formation could substantially benefit ruminant production.
Detecting Learning Moment-by-Moment (2011)

Intelligent tutors have become increasingly accurate at detecting whether a student knows a skill, or knowledge component (KC), at a given time. However, current student models do not tell us exactly at which point a KC is learned. In this paper, we present a machine-learned model that assesses the probability that a student learned a KC at a specific problem step (instead of at the next or previous problem step). We use this model to analyze which KCs are learned gradually, and which are learned in “eureka” moments. We also discuss potential ways that this model could be used to improve the effectiveness of cognitive mastery learning.
Industrial High Pressure Applications (2012)

Industrial High Pressure Applications, Processes, Equipment and Safety , Industrial High Pressure Applications, Processes, Equipment and Safety , کتابخانه الکترونیک و دیجیتال - آذرسا
The Opportunity To Eradicate Peste des Petits Ruminants (2016)

Peste des petits ruminants (PPR) is a highly infectious disease of sheep and goats that is caused by PPR virus, a member of the genus Morbillivirus that includes the viruses that cause rinderpest (RP) in cattle. RP was the first animal disease to be globally eradicated in 2011 and is only the second disease, after smallpox, to have ever been eradicated. PPR is one of the principal constraints to small ruminant production in Africa, Asia, and the Middle East. The epidemiology of PPR and RP as well as the technologies available for their diagnosis and control are similar. The conditions that favored the eradication of RP are also largely present for PPR. In this work, we outline the evolving strategy for eradication in light of current opportunities and challenges, as well as the lessons from other eradication programs in animal and human health. The global PPR situation and technology for its control are summarized. A strategy based on the lessons from previous eradication efforts that integrate epidemiology, social science, and economics as tools to target and motivate vaccination is summarized. Major aspects of the cost and benefit-cost analysis of the indicated program are presented. The overall undiscounted cost of eradication was estimated as $3.1 billion, and the benefit-cost ratio for the most likely scenario was estimated at 33.8. We close with a discussion of the possible next steps.
SCOP database in 2002: refinements accommodate structural genomics (2002)

The SCOP (Structural Classification of Proteins) database is a comprehensive ordering of all proteins of known structure, according to their evolutionary and structural relationships. Protein domains in SCOP are grouped into species and hierarchically classified into families, superfamilies, folds and classes. Recently, we introduced a new set of features with the aim of standardizing access to the database, and providing a solid basis to manage the increasing number of experimental structures expected from structural genomics projects. These features include: a new set of identifiers, which uniquely identify each entry in the hierarchy; a compact representation of protein domain classification; a new set of parseable files, which fully describe all domains in SCOP and the hierarchy itself. These new features are reflected in the ASTRAL compendium. The SCOP search engine has also been updated, and a set of links to external resources added at the level of domain entries. SCOP can be accessed at http://scop.mrc-lmb.cam.ac.uk/scop.
Glottic Closing Force Versus Laryngeal Adductory Pressure in the Canine Larynx (2016)

This method for measuring GCF appears valid. The high Pearson's correlation coefficient indicates strong covariance between GCF and LAP, demonstrating that they are both measures of the same physical property. The LAP is easier to perform and more consistently obtained.
Neoplastic Transformation of Fetal Rat Brain Cells in Culture After Exposure to Ethylnitrosourea In Vivo23 (1975)

A single, transplacental pulse of N-ethyl-N-nitrosourea (ENU; 75 mug/g body wt) to the fetal (18th day of gestation) BD IX rat led to death with malignant tumors of the central and peripheral nervous system after a median time of approximately 195 days. In contrast to untreated control cells, dissociated brain cells transferred to long-term cell culture 20-90 hours after the ENU pulse became tumorigenic after approximately 200 days, as assayed by reimplantation into baby BD IX rats. This was preceded by a characteristic sequence of phenotypic alterations (termed "stages I-IV"). During early primary culture (stage I), both ENU and control cultures exhibited stationary glia-like cells on a growing layer of epithelioid (possibly glia precursors) and few fibroblast-like cells. Stage II (approximately 10th-40th day) was characterized by a constant proportion of glia-like cells in the ENU cultures and by their disappearance in the controls. During stage III (approximately 40th-100th day), slowly proliferating glia-like cells in the ENU cultures formed "piled-up" foci. They could then be removed from the underlying cell layer and cultured separately. Transition to stage IV (approximately 100th-200th day) was marked by proliferation of morphologically altered cells, which subsequently acquired the capacity of form colonies in semisolid agar and finally became tumorigenic (stage V). This system may represent a model for the study of malignant transformation.
An Animal Model for Coexisting Tardive Dyskinesia and Tardive Parkinsonism (1993)

There is now ample evidence for long-term malfunctioning within five different brain GABAergic pathways in a monkey model for tardive dyskinesia (TD). Three of these GABA connections (GPe-STN, CP-SNr, and CP-GPi) are chronically downregulated during neuroleptic treatment and after some years they do not seem to regain their normal activity, even when the neuroleptics are discontinued. The persistent downregulation of these three GABA connections, evidenced by depressions of terminal GAD activity and GABA levels, appears to be a conceivable mechanism behind tardive parkinsonism (TP), often reported to coexist with TD in the clinic. The TD patients' well-known lack of awareness of their symptoms may be due to their parkinsonian "sensory neglect." Another two GABA malfunctioning connections were found in our monkey model: SNr-VA/VL and GPi-VA/VL. These pathways are upregulated during chronic neuroleptic treatment, partly due to an elevated glutamate release within subthalamofugal pathways. This chronic glutamatergic hyperactivity may have acted via an excitotoxic mechanism and consequently both GPi and VA/VL had a low synaptic activity in our dyskinetic monkeys, as measured by 2-deoxyglucose uptake, even 4 months after the last neuroleptic dose. It is hypothesized that TD may be due to an excitotoxic lesion of the inhibitory GABAergic VA/VL afferents, while TP has to do with persistent malfunctioning of downregulated SNr and GPi afferents.
Challenging Drug Resistance in Cancer Therapy: Review of the First Nordic Conference on Chemoresistance in Cancer Treatment, October 9th and 10th, 1997 (1998)

The First Nordic Conference on Chemoresistance in Cancer Treatment was held in the Danish town of Helsingør on October 9th and 10th, 1997, under the auspices of the Nordic Cancer Chemoresistance Group (NCCG). The meeting focused on biochemical chemoresistance in a multidisciplinary approach. There were 19 oral and 15 poster presentations documenting recent advances in experimental and clinical research of drug transport mechanisms, DNA repair systems, detoxifying enzymes, drug target regulation, in vitro sensitivity tests, apoptosis inhibition, and strategies to circumvent chemoresistance. In the present paper we review the main issues that were addressed and discuss the findings with reference to the current literature in the field. The meeting demonstrated the plurality and the complexity of chemoresistance, which is a major obstacle to successful chemotherapy in cancer patients. The new insights to mechanisms of drug resistance and sensitization represent a useful basis for further development of strategies to circumvent chemoresistance in clinical practice.
Modifying Aluminum Reactivity with Poly(Carbon Monofluoride) via Mechanical Activation (2013)

Abstract Modification of the reactivity of micrometer‐sized aluminum through inclusion of low levels of poly(carbon monofluoride) (PMF) using mechanical activation (MA) is reported. Resulting composite particle combustion enthalpy, average particle size, and specific surface area depend on MA intensity, duration, and inclusion level, and range from 18.9 to 28.5 kJ g −1 , 23.0 to 67.5 μm, and 5.3 to 34.8 m 2 g −1 , respectively. Differential scanning calorimetry experiments in O 2 /Ar indicate that MA reduces the exotherm onset from 555 to 480 °C (70/30 wt‐%). Particles are sensitive to electrostatic discharge stimulus (11.5–47.5 mJ) but not to impact (>213 cm) or friction (>360 N) and some low energy MA particles are ignitable by optical flash. With their altered reactivity and high combustion enthalpy, these nanofeatured, micrometer‐sized particles may have use as replacements for aluminum in energetic applications.
SOME PSYCHOLOGICAL METHODS FOR EVALUATING THE QUALITY OF TRANSLATIONS (1956)

The excellence of a translation should be measured by the extent to which it preserves the exact meaning of the original. But so long as we have no accepted definition of meaning, much less of exact meaning, it is difficult to use such a measure. As a practical alternative, therefore, we must search for more modest, yet better defined, procedures. The present article attempts to survey some of the possible methods: One can ask the opinion of several competent judges. Or, given a translation of granted excellence, one can compare test translations with this criterion by a variety of statistical indices. Or a person who has read only the translation may be required to answer questions based on the original. The characteristic advantages and disadvantages of each method are illustrated by examples.
Black Box Chimera Check (B2C2): a Windows-Based Software for Batch Depletion of Chimeras from Bacterial 16S rRNA Gene Datasets (2010)

The existing chimera detection programs are not specifically designed for "next generation" sequence data. Technologies like Roche 454 FLX and Titanium have been adapted over the past years especially with the introduction of bacterial tag-encoded FLX/Titanium amplicon pyrosequencing methodologies to produce over one million 250-600 bp 16S rRNA gene reads that need to be depleted of chimeras prior to downstream analysis. Meeting the needs of basic scientists who are venturing into high-throughput microbial diversity studies such as those based upon pyrosequencing and specifically providing a solution for Windows users, the B2C2 software is designed to be able to accept files containing large multi-FASTA formatted sequences and screen for possible chimeras in a high throughput fashion. The graphical user interface (GUI) is also able to batch process multiple files. When compared to popular chimera screening software the B2C2 performed as well or better while dramatically decreasing the amount of time required generating and screening results. Even average computer users are able to interact with the Windows .Net GUI-based application and define the stringency to which the analysis should be done. B2C2 may be downloaded from http://www.researchandtesting.com/B2C2.
A Blockchain Based Decentralized Computing And NFT Infrastructure For Game Networks (2020)

The market value of the Gaming industry was said to be over 138 Billion USD in 2019. Competitive Gaming or eSports was already included in the Asian Games 2020, and the Olympic committee is considering including eSports into Olympics 2024. The online gaming segment amounts up to 7 quintillion bytes of internet traffic every month. Most of this data is controlled by centralized gatekeepers like cloud agencies and game creators. This is causing many issues ranging from privacy concerns to latency. The game makers have complete rights over the game to arbitrarily change the rules, set prices for the assets, and control over game servers. Even the reward mechanisms in most of the games, including eSports, are controlled by the game producers, and these rewards have no real-world value. The motivation behind this research is to create a decentralized computation and token management infrastructure for game networks. This paper focuses on using Ethereum Blockchain, IPFS and ERC - Ethereum Request for Comment 1155 architecture to build a gaming-oriented public decentralized network.
Is a Thymine Dimer Replicated via a Transient Abasic Site Intermediate? A Comparative Study Using Non-Natural Nucleotides (2007)

UV light causes the formation of thymine dimers that can be misreplicated to induce mutagenesis and carcinogenesis. This report describes the use of a series of non-natural indolyl nucleotides in probing the ability of the high-fidelity bacteriophage T4 DNA polymerase to replicate this class of DNA lesion. Kinetic data reveal that indolyl analogues containing large pi-electron surface areas are incorporated opposite the thymine dimer almost as effectively as an abasic site, a noninstructional lesion. However, there are notable differences in the kinetic parameters for each DNA lesion that indicate distinct mechanisms for their replication. For example, the rate constants for incorporation opposite a thymine dimer are considerably slower than those measured opposite an abasic site. In addition, the magnitude of these rate constants depends equally upon contributions from pi-electron density and the overall size of the analogue. In contrast, binding of a nucleotide opposite a thymine dimer is directly correlated with the overall pi-electron surface area of the incoming dXTP. In addition to defining the kinetics of polymerization, we also provide the first reported characterization of the enzymatic removal of natural and non-natural nucleotides paired opposite a thymine dimer through exonuclease degradation or pyrophosphorolysis activity. Surprisingly, the exonuclease activity of the bacteriophage enzyme is activated by a thymine dimer but not by an abasic site. This dichotomy suggests that the polymerase can "sense" bulky lesions to partition the damaged DNA into the exonuclease domain. The data for both nucleotide incorporation and excision are used to propose models accounting for polymerase "switching" during translesion DNA synthesis.
A Piecewise Linear Interface-Capturing Volume-of-Fluid Method Based on Unstructured Grids (2012)

A piecewise linear interface calculation (PLIC) technique on triangular unstructured grids is proposed for the volume-of-fluid (VOF) method. For an interface cell, a straight line segment is set to approximate the actual interface by the gradient of the volume fraction function. Three gradient models are discussed, and the results show that the gradient model introduced from the moving particle semi-implicit method is of the highest accuracy. Mass flux is calculated in a Eulerian scheme depending on the relationship between the line segment and each boundary of the cell. It is proved that the combination of geometric and algebraic methods is most precise, because both geometric interface position and algebraic mass conservation are considered. Numerical experiments are conducted on unstructured grids generated by the traditional Delaunay triangulation method and the bubble packing method (BPM), which can produce much more regular triangular cells than the Delaunay method (see Wu and Chen, Numerical Heat T...
Effect of lidocaine on lens epithelial cells (2004)

We commend Vargas and coauthors for their excellent work evaluating the effect of lidocaine on lens epithelial cells (LECs). By using lidocaine 1% for hydrodissection, they found that LECs were virtually eliminated from the anterior capsule. We certainly concur that lidocaine can be used effectively for hydrodissection. We would like to raise a word of caution, however. When using higher dosages of lidocaine (as would be required for hydrodissection), the risk for toxic anterior segment syndrome (TASS) may increase. Three of our patients who received 1.5 cc of preservative-free lidocaine 1% experienced TASS. Although other factors have been implicated as causes of TASS,1–3 we believe lidocaine was the culprit among our patients for the following reasons: TASS occurred only in patients who received topical anesthesia supplemented with intraocular lidocaine. One case involved a toric rotation procedure in which lidocaine was the only intraocular fluid introduced. In each incident, the patient received a higher dosage than is normally administered during cataract surgery. We therefore recommend judicious use of lidocaine for hydrodissection and limiting the amount administered to 1.0 cc. James P Gills MD Tampa, FL, USA
Low-complexity channel estimation in large-scale MIMO using polynomial expansion (2013)

This paper considers pilot-based channel estimation in large-scale multiple-input multiple-output (MIMO) communication systems, also known as “massive MIMO”. Unlike previous works on this topic, which mainly considered the impact of inter-cell disturbance due to pilot reuse (so-called pilot contamination), we are concerned with the computational complexity. The conventional minimum mean square error (MMSE) and minimum variance unbiased (MVU) channel estimators rely on inverting covariance matrices, which has cubic complexity in the multiplication of number of antennas at each side. Since this is extremely expensive when there are hundreds of antennas, we propose to approximate the inversion by an L-order matrix polynomial. A set of low-complexity Bayesian channel estimators, coined Polynomial ExpAnsion CHannel (PEACH) estimators, are introduced. The coefficients of the polynomials are optimized to yield small mean square error (MSE). We show numerically that near-optimal performance is achieved with low polynomial orders. In practice, the order L can be selected to balance between complexity and MSE. Interestingly, pilot contamination is beneficial to the PEACH estimators in the sense that smaller L can be used to achieve near-optimal MSEs.
Guiding Extractive Summarization with Question-Answering Rewards (2019)

Kristjan Arumae, Fei Liu. Proceedings of the 2019 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 1 (Long and Short Papers). 2019.
On the fractal nature of heart rate variability in humans: effects of vagal blockade (1995)

The purpose of the present study was to investigate the effects of the vagal blocker atropine on the fractal nature of human heart rate variability (HRV) at rest. Approximately 10-min segments of beat-to-beat heartbeat intervals, i.e., HRV, of 10 normal subjects and 11 cardiac disease patients were measured before and after intravenous injection of 0.5-0.75 mg atropine sulfate. HRV data were analyzed by coarse graining spectral analysis (Y. Yamamoto and R. L. Hughson, Physica 68D: 250-264, 1993) to break down their total power into harmonic and nonharmonic (fractal) components. The harmonic component was used to calculate the contribution of high (> 0.15 Hz)-frequency components to total HRV power (%HF). From the fractal component, the contribution of the fractal component to total HRV power (%fractal), the spectral exponent beta, and Hurst scaling exponent (H) were calculated. For both normal subjects and cardiac patients, atropine resulted in significantly (P < 0.05) less mean HRV and significantly (P < 0.05) greater beta compared with control, whereas mean values for %fractal were as high as 70% and were not significantly (P > 0.05) different between atropine and control. The mean value of H with atropine was significantly (P < 0.05) greater than that for control. Directional changes in %HF and beta were consistent with only one exception for a patient who had the smallest change in log %HF by atropine. The normally irregular fractal pattern of resting HRV was decreased by atropine as shown by the decrease in %HF and the increase in beta.(ABSTRACT TRUNCATED AT 250 WORDS)