gebhart/patrepeval huggingface dataset:
Perpendicular magnetic anisotropy in chemically disordered FePd–FeV(100) alloy thin films (2006)

We find that the use of V(100) buffer layers on MgO(001) substrates for the epitaxy of FePd binary alloys yields to the formation at intermediate and high deposition temperatures of a FePd–FeV mixed phase due to strong V diffusion accompanied by a loss of layer continuity and strong increase of its mosaic spread. Contrary to what is usually found in this kind of systems, these mixed phase structures exhibit perpendicular magnetic anisotropy (PMA) which is not correlated with the presence of chemical order, almost totally absent in all the fabricated structures, even at deposition temperatures where it is usually obtained with other buffer layers. Thus the observed PMA can be ascribed to the V interdiffusion and the formation of a FeV alloy, being the global sample saturation magnetization also reduced.
Dopamine D2 receptor availability is linked to hippocampal–caudate functional connectivity and episodic memory (2016)

D1 and D2 dopamine receptors (D1DRs and D2DRs) may contribute differently to various aspects of memory and cognition. The D1DR system has been linked to functions supported by the prefrontal cortex. By contrast, the role of the D2DR system is less clear, although it has been hypothesized that D2DRs make a specific contribution to hippocampus-based cognitive functions. Here we present results from 181 healthy adults between 64 and 68 y of age who underwent comprehensive assessment of episodic memory, working memory, and processing speed, along with MRI and D2DR assessment with [(11)C]raclopride and PET. Caudate D2DR availability was positively associated with episodic memory but not with working memory or speed. Whole-brain analyses further revealed a relation between hippocampal D2DR availability and episodic memory. Hippocampal and caudate D2DR availability were interrelated, and functional MRI-based resting-state functional connectivity between the ventral caudate and medial temporal cortex increased as a function of caudate D2DR availability. Collectively, these findings indicate that D2DRs make a specific contribution to hippocampus-based cognition by influencing striatal and hippocampal regions, and their interactions.
Exposure to ozone reduces postharvest quality loss in red and green chilli peppers (2016)

The effect of continuous exposure to ozone at 0.45, 0.9 and 2μmolmol(-1) on quality changes during the storage of red and green chilli peppers at 10°C was investigated. Ozone at 0.45 and 0.9μmolmol(-1) reduced disease incidence in red peppers, with no further benefits at 2μmolmol(-1). Ozone at 0.9μmolmol(-1) reduced weight loss during storage and improved firmness maintenance. Skin colour was bleached in red peppers exposed to ozone at 2μmolmol(-1), and in green ones at all tested doses. Total phenolic content was not affected by ozone but antioxidant activity was reduced in green chilli peppers exposed to ozone at 2μmolmol(-1), due to lower ascorbic acid content in those samples. Ozone at 0.9μmolmol(-1) extended the shelf-life of chilli peppers.
Summary: Viral Studies of Chronic Fatigue Syndrome (1994)

Journal Article Summary: Viral Studies of Chronic Fatigue Syndrome Get access Dharam V. Ablashi Dharam V. Ablashi From the National Cancer Institute, Bethesda, Maryland; and the Georgetown University School of Medicine, Washington, D.C. Reprints or correspondence: Dr. Dharam V. Ablashi, 4117 Barnsley Lane, Olney, Maryland 20832. Search for other works by this author on: Oxford Academic PubMed Google Scholar Clinical Infectious Diseases, Volume 18, Issue Supplement_1, January 1994, Pages S130–S133, https://doi.org/10.1093/clinids/18.Supplement_1.S130 Published: 01 January 1994
IoT-based real time signature authentication and transfer from document to document with DNA encryption (2016)

The main idea of this paper is to suggest a way in which, by using the Internet of Things (IoT), a person can sign a document in a particular place, and have it reflect simultaneously on a similar document elsewhere, in real time. The primary user (authenticator) uses a digital pen to sign the paper document. The signature area of the document contains a particular dot pattern which helps the digital pen track the movements as the signature is created. While the paper is being signed, the digital pen also records the user's fingerprint for later verification. The obtained information is then converted to binary bits and is encoded using DNA encryption. This cipher data is transmitted to the secondary user (receiver) where the cipher is decoded and printed on the second copy of the document. Thus, the signature is securely transferred from one paper to the other.
VCTA: A Via-Configurable Transistor Array regular fabric (2010)

Layout regularity is introduced progressively by integrated circuit manufacturers to reduce the increasing systematic process variations in the deep sub-micron era. In this paper we focus on a scenario where layout regularity must be pushed to the limit to deal with severe systematic process variations in future technology nodes. With this objective, we propose and evaluate a new regular layout style called Via-Configurable Transistor Array (VCTA) that maximizes regularity at device and interconnect levels. In order to assess VCTA maximum layout regularity tradeoffs, we implement 32-bit adders in the 90 nm technology node for VCTA and compare them with implementations that make use of standard cells. For this purpose we study the impact of photolithography proximity and coma effects on channel length variations, and the impact of shallow trench isolation mechanical stress on threshold voltage variations. We demonstrate that both variations, that are important sources of energy and delay circuit variability, are minimized through VCTA regularity.
Built-in field electroabsorption spectroscopy of polymer light-emitting diodes incorporating a doped poly(3,4-ethylene dioxythiophene) hole injection layer (1999)

We report electroabsorption measurements of polymer light-emitting diodes, (LEDs), fabricated with poly(4-4′-diphenylene diphenylvinylene), PDPV, as the emissive layer, Ca–Al cathodes, and indium tin oxide (ITO) anodes, with and without a doped conducting polymer hole injection/transport layer, namely poly(3,4-ethylene dioxythiophene), PEDOT, doped with poly(styrene sulfonate), PSS−. In these structures, the bias at which the electroabsorption signal is null corresponds to the difference between the electrodes’ work functions. We find that such a built-in voltage increases by 0.5 V when a PEDOT:PSS film is incorporated between the ITO electrode and the emissive layer. This leads to a marked reduction of the anode barrier height at the hole-injecting interface, and accounts for a variety of improvements brought about by the PEDOT insertion, namely: (a) the increase of luminescence efficiency, (b) the reduction of the turn-on voltage, and (c) the increase of the device lifetime.
In Vitro and In Vivo Laboratory Evaluation of Cephaloglycin and Cephaloridine (1965)

Two new antibiotics, structurally related to cephalothin, have been given the generic names cephaloglycin and cephaloridine. Cephaloglycin is the dipolar ion of 7-(d-alpha-aminophenylacetamido)-cephalosporanic acid. Cephaloridine is 7-[alpha-(2-thiophene)acetamido]-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid betaine. These new compounds were evaluated simultaneously. The broad spectrum of activity observed in vitro and in vivo with both antibiotics, the good oral absorption obtained with cephaloglycin, and the stability of cephaloridine are emphasized. The data suggest that both antibiotics merit clinical trial in humans.
The outline of EAGLE Project (Coal Energy Application for Gas, Liquid, and Electricity) (2002)

The purpose of the EAGLE (coal Energy Application for Gas, Liquid and Electricity) Project is to develop the technology to produce coal gas for fuel cells. The EAGLE system applies an oxygen blown, entrained flow type gasifier, in which the spiral flow is formed. Oxygen is produced with an ASU (Air Separation Unit) and supplied to the gasifier. The produced coal gas is cooled through the radiant section of the gasifier and a syngas cooler. Impurities in raw syngas are removed with water scrubbers, a COS converter and an MDEA (Methyl Di-Ethanol Amine) absorber. Part of the syngas is further desulfurized with iron oxides for fuel cells. The EAGLE Project is subsidized by METI (Ministry of Economy, Trade and Industry) and NEDO (New Energy and Industrial Technology Development Organization). In 1995,a feasibility study of IGFC (Integrated coal Gasification Fuel Cell combined cycle) systems was conducted. In 1996 and 1997,a basic design and a detailed design were carried out, respectively. Its construction work was started at Wakamatsu Operations & General Management Office in August 1998. A pilot plant test has continuing since July 2001.
Carrying PWE3 Pseudo Wires over Provider Backbone Transport (2007)

Provider Backbone Transport (PBT, known as well as PBB-TE and
progressed in IEEE as 802.1Qay [802.1Qay]) provides a mechanism where
native Ethernet point-to-point tunnels can be configured or signaled
across a provider-based Ethernet network [FEDYK]. PWE3 architecture
defines a mechanism, called pseudowires, that emulates the essential
attributes of a layer-2 and layer-1 service over a Packet Switched
Network (PSN). This draft describes the architecture and procedures
where Pseudowires are carried across PBT tunnels. In this proposal PBT
tunnels are used as the PSN.
A non-radioactive method to detect RNA or DNA using an oligonucleotide probe with bromodeoxyuridine free ends, a monoclonal antibody against bromodeoxyuridine and immunogold silver staining (1989)

A non radioactive method for probing RNA or DNA on dot and Northern blots using a synthetic oligonucleotide with bromodeoxyuridine free ends is described. The present experiment was carried out with human testis and placental RNA's. The probe was the 21 base long sequence coding for the amino acids 18 to 24 of the insulin-like growth factor I (IGF-I) with two bromodeoxyuridine dinucleotides added at the 5' and 3' ends. The probe was detected with a monoclonal antibody against bromodeoxyuridine and immunogold silver staining (IGSS). Our method was compared to the peroxydase (HRP) revelation of the same probe. The results obtained show a lower background with IGSS than with HRP revelation. A sensitivity similar to that of 32P labelling was found with the advantages of an increase in the rapidity of the procedure (24 hours instead of 9 days exposure) and the absence of handling radioactive substances. Moreover, as the monoclonal antibody against BrdU detects single stranded DNA only, the use of BrdU free ends-labelled oligonucleotide allows the development of the revelation procedure without any previous denaturation of the hybrid. This particular point is an indisputable advantage for detecting hybridization in situ.
Weak Localization of Seismic Waves (2004)

We report the observation of weak localization of seismic waves in a natural environment. It emerges as a doubling of the seismic energy around the source within a spot of the width of a wavelength, which is several tens of meters in our case. The characteristic time for its onset is the scattering mean-free time that quantifies the internal heterogeneity.
6.2: A High‐Performance Novel Polarizer Based on Dyestuff (1998)

Abstract The polarizer based on dyestuff has advanced remarkably in performance. With its high durability, the optical performance of the newly developed polarizer has been extremely improved as compared with the conventional one on the market, and has become similar to that of the high contrast polarizer based on iodine. Characteristics of the new polarizer will be described.
Patient‐reported outcomes from EMILIA, a randomized phase 3 study of trastuzumab emtansine (T‐DM1) versus capecitabine and lapatinib in human epidermal growth factor receptor 2–positive locally advanced or metastatic breast cancer (2013)

Together with the EMILIA primary data, these results support the concept that T-DM1 has greater efficacy and tolerability than capecitabine plus lapatinib, which may translate into improvements in health-related quality of life.
Clopidogrel, Genetics, and Drug Responsiveness (2009)

Despite great progress in the diagnosis and treatment of unstable coronary syndromes, it is estimated that 785,000 Americans will have new acute cardiac events and 470,000 will have recurrent events this year.1 Central to the pathogenesis of acute coronary syndromes is the adhesion and activation of platelets leading to aggregation, thrombus formation, and vessel occlusion. Unfortunately, the absolute risk of recurrent vascular events among patients taking platelet inhibitors remains relatively high.1 The observation that platelet-dependent thrombosis occurs despite treatment with platelet inhibitors has led to a large number of studies assessing the cause of these treatment failures. Often termed “resistance,” . . .
Barrier and Antibacterial Properties of 2-Octyl Cyanoacrylate-Derived Wound Treatment Films (2003)

Background: Besides enhancing healing, an ideal dressing should prevent invasion of pathogens and control the number of bacteria already present in the wounds. Objective: To evaluate the barrier and antimicrobial properties of a cyanoacrylate-based bandage (LAB) against Staphylococcus aureus or Pseudomonas aeruginosa on partial thickness wounds in swines. Methods: Barrier study: Bacteria were inoculated over test materials (LAB, standard bandage, air-exposed) that were placed over wounds. The bacteria from wounds were quantitated at 24, 48, and 72 hours postinoculation. Antimicrobial study: Wounds inoculated with bacteria were covered with LAB, standard bandage, or hydrocolloid bandage or left air-exposed. The bacteria recovered from wounds were quantitated at 24 and 72 hours after treatment. Results: Barrier study: No bacteria were recovered from LAB-treated wounds. Antimicrobial study: LAB reduced the number of inoculated bacteria in comparison to all other groups. Conclusion: LAB is effective in protecting wounds from external bacterial invasion and reducing bacterial contamination.
Two More Clint Eastwood Masterpieces (2009)

Changeling is supposed to have missed out by two votes on the Golden Palm at last year's Cannes Film Festival because some of the jury found the story far too incredible even for an American movie. It is easy to see why. A boy disappears from the home of his working-class single mother. After some months the police return a different child. Nevertheless they insist the mother keep the boy. When she demands they look for her real son the officer in charge of the case commits her to an insane asylum. If this were not sufficiently melodramatic, the film includes a major subplot about the hunting down of a serial killer of young boys portrayed in imagery that seems to have come straight from The Texas Chainsaw Massacre.
Doubly-Differential Coherent 100G Transmission: Multi-Symbol Decision-Directed Carrier Phase Estimation with Intradyne Frequency Offset Cancellation (2010)

The proposed novel carrier phase and frequency recovery system automatically cancels LO frequency offsets, outperforming conventional schemes in mean square phase error, with low complexity linear processing, using a low number of complex-multiply-adds.
Use of drains in foot surgery. (1988)

The purpose of this article is to describe how drains can be effective for foot surgeons. Emphasis is placed upon the closed-wound drainage system which was designed for outpatient surgery. Removing transudative or exudative fluids will promote the healing time of a wound that would otherwise delay tissue granulation. These drains eliminate dead space by exerting a negative pressure by means of a perforated catheter, tube, and reservoir. Edema is decreased, and layers of tissue are allowed to adhere faster. The portable closed wound drainage system removes drainage against gravity to allow faster rehabilitation.
Optimal Placement of Wind Turbines in Wind Farm Layout Using Particle Swarm Optimization (2021)

An optimal geographical location of wind turbines can ensure the optimum total energy output of a wind farm. This study introduces a new solution to the optimization of wind farm layout (WFLO) problem based on a three-step strategy and particle swarm optimization as the main method. The proposed strategy is applied to a certain WFLO to generate highly efficient optimal output power. Three case scenarios are considered to formulate the non-wake and wake effects at various levels. The required wind turbine positions within the wind farm are determined by the particle swarm optimization method. The rule of thumb, which determines the wind turbine spacing, is thoroughly considered. The MATLAB simulation results verify the proposed three-step strategy. Moreover, the results are compared with those of existing research works, and it shows that the proposed optimization strategy yields a better solution in terms of total output power generation and efficiency with a minimized objective function. The efficiencies of the three case studies considered herein increase by 0.65%, 1.95%, and 1.74%, respectively. Finally, the simulation results indicate that the proposed method is robust in WFLO design because it further minimizes the objective function.
Reduction of Advanced-Glycation End Products Levels and Inhibition of RAGE Signaling Decreases Rat Vascular Calcification Induced by Diabetes (2014)

Advanced-glycation end products (AGEs) were recently implicated in vascular calcification, through a process mediated by RAGE (receptor for AGEs). Although a correlation between AGEs levels and vascular calcification was established, there is no evidence that reducing in vivo AGEs deposition or inhibiting AGEs-RAGE signaling pathways can decrease medial calcification. We evaluated the impact of inhibiting AGEs formation by pyridoxamine or elimination of AGEs by alagebrium on diabetic medial calcification. We also evaluated if the inhibition of AGEs-RAGE signaling pathways can prevent calcification. Rats were fed a high fat diet during 2 months before receiving a low dose of streptozotocin. Then, calcification was induced with warfarin. Pyridoxamine was administered at the beginning of warfarin treatment while alagebrium was administered 3 weeks after the beginning of warfarin treatment. Results demonstrate that AGEs inhibitors prevent the time-dependent accumulation of AGEs in femoral arteries of diabetic rats. This effect was accompanied by a reduced diabetes-accelerated calcification. Ex vivo experiments showed that N-methylpyridinium, an agonist of RAGE, induced calcification of diabetic femoral arteries, a process inhibited by antioxidants and different inhibitors of signaling pathways associated to RAGE activation. The physiological importance of oxidative stress was demonstrated by the reduction of femoral artery calcification in diabetic rats treated with apocynin, an inhibitor of reactive oxygen species production. We demonstrated that AGE inhibitors prevent or limit medial calcification. We also showed that diabetes-accelerated calcification is prevented by antioxidants. Thus, inhibiting the association of AGE-RAGE or the downstream signaling reduced medial calcification in diabetes.
Pharmacological classification of adenosine receptors in the sinoatrial and atrioventricular nodes of the guinea‐pig (1998)

1. The effects of seven agonist and three antagonist adenosine receptor ligands were compared on the guinea-pig sinoatrial (SA) node (isolated right atrium) and atrioventricular (AV) node (perfused whole heart). Single agonist concentration-effect curves were obtained to 5'-N-ethylcarboxamidoadenosine (NECA), R(-)-N6-(2-phenylisopropyl)adenosine (R-PIA), N6-cyclohexyladenosine (CHA), 2-chloroadenosine (CADO),),S(+)-N6-(2-phenylisopropyl)adenosine (L-PIA), 2-phenylaminoadenosine (CV 1808) and N6-aminoadenosine (MeAdo). Adenosine and/or NECA curves were obtained in the absence and presence of the antagonists 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), 9-chloro-2 (2-furanyl)-5,6-dihydro-1,2,4-triazolo[1,5-c]quinazolin-5-imine (CGS15943) and N6-(endonorbornan-2-yl)-9-methyladenine (N-0861). 2. A formal comparison of the agonist and antagonist potency data was made by fitting the data to a straight line using a least squares procedure based on principal components analysis to account for the variance on both axes. The antagonist affinity estimates made on the two assays did not deviate significantly from the line of identity. 3. The agonist p[A]50 data obtained on the two assays did not deviate from the line of identity, indicating that there were no significant differences in potencies between the two assays. The p[A]50 ratio of R-PIA and S-PIA was 1.24+/-0.09 in the SA node and 1.36+/-0.11 in the AV node, indicating no difference in the stereoselectivity of the PIA isomers between the two tissues. 4. The agonist potency and antagonist affinity data obtained are consistent with previous findings showing that the AV and SA node data are pharmacologically indistinguishable and belong to the adenosine A1-receptor class. No evidence for the reported A3-receptor was found.
Waveguide Zeeman interferometry for thin-film chemicalsensors (1997)

The authors demonstrate a highly sensitive chemical sensor scheme based on Si3N4 channel waveguides, species-selective surface coatings and Zeeman interferometry. The relative phase change between the TE and TM modes under exposure to toluene vapour is measured. The measurements demonstrate the real-time and reversible response with good sensitivity at low concentrations.
RTA 1701 is an oral RORγt inhibitor that suppresses the IL-17A response in non-human primates (2018)

Abstract RTA 1701 is an orally-bioavailable, selective RORγt inhibitor. RORγt orchestrates the differentiation of Th17 cells and contributes to autoimmune disease pathogenesis. Inhibition of RORγt suppresses Th17 cells and the associated secretion of the effector pro-inflammatory cytokine IL-17A. As such, RTA 1701 is highly efficacious in rodent models of rheumatoid arthritis and multiple sclerosis. This study was conducted to evaluate the pharmacokinetics of RTA 1701 and its effects on ex vivo stimulation of IL-17A production in whole blood after oral administration to naïve healthy cynomolgus monkeys. Monkeys received a single administration of RTA 1701 (0.3, 3, 30, or 300 mg/kg). After a one-week washout, monkeys received the same doses of RTA 1701 once daily for 14 consecutive days. Blood was collected after a single dose and after 14 days of dosing for analysis of plasma RTA 1701 concentrations through 72 hours post-dose and for evaluation of RTA 1701 effects on ex vivo stimulation of IL-17A at 24, 30, and 72 hours post-dose. RTA 1701 exhibited oral bioavailability in monkeys with dose-dependent increases in exposure over the wide range of doses evaluated. Further, oral administration produced systemic exposure to RTA 1701 at sufficient levels to produce significant and dose-dependent suppression of ex vivo stimulation of IL-17A secretion in whole blood at 24 and 30 hours after single and repeat dosing, with IL-17A levels returning to baseline within 72 hours after a single dose. Collectively, these data demonstrate that RTA 1701 is orally bioavailable in non-human primates and significantly suppresses the IL-17A response. These data also support the future clinical development of RTA 1701 for the potential treatment of autoimmune diseases.