gebhart/patrepeval huggingface dataset:
The ultrastructure of the anterior end of male<i>Onchocerca volvulus</i>: papillae, amphids, nerve ring and first indication of an excretory system in the adult filarial worm (1996)

A detailed morphological investigation of the anterior sensory organs, the nerve ring and a glomerulus-like structure in male Onchocerca volvulus was performed by means of electron microscopy. The 8 head papillae are arranged in the common 4 + 4 pattern of most filarial worms in circles around the mouth opening. The amphidial openings are found between the circles of inner and outer papillae on both sides of the mouth. Inside, several additional nerve axons are seen in the tissue of the anterior tip not related to one of the identified papillar structures. The inner and outer papillae exhibit a remarkably different fine structure, and are part of a complex system of at least 2 different receptor cell types at the anterior tip of the worm. The amphidial channel contains 8 modified cilia; accessory axons are associated with the cytoplasm of the sheath cell. The anterior nerve ring of male worms is located about 150 micrometers posterior from the outermost tip of the head region. It consists of several fibres coiled around the oesophagus. The comparison of the fine structure of the central nervous system did not show the expected morphological differences associated with the heterogeneous age distribution in the natural worm population. This was in contrast to previous findings with respect to tissues in different parts of the worm. The study also provides the first evidence that suggests the existence of an excretory organ in a filarial worm in the region of the anterior nerve ring. Paired glomerulus-like structures in the lateral chords and a canal formed by a projection of the basal zone of the cuticles were identified.
KICKING A VIRTUAL TIRE - THE INTERNET IS CHANGING HOW CARS ARE MADE AND SOLD (1999)

This article discusses the purchasing of motor vehicles online, through the Internet. It presents cases, web sites, and car dealers reactions to Internet purchases. It lists web sites by the following classifications - information only, referrals, middlemen, direct purchases, and reverse auctions.
A 60GHz 1V +12.3dBm Transformer-Coupled Wideband PA in 90nm CMOS (2008)

The opening up of the mm-wave band has created opportunities for high-data-rate communication, radar and medical imaging. The cost and size advantages of CMOS have motivated research on 60GHz CMOS front-end design [1]. However, very few CMOS mmwave power amplifiers (PAs) have been reported so far. Furthermore, most of the mm-wave PAs reported use bulky transmission lines [2, 3], increasing silicon area and incurring higher substrate losses. We demonstrate a fully integrated 60GHz transformer-coupled two-stage differential power amplifier with single-ended input and output in 90nm digital CMOS with no RF process options. This work uses on-chip transformers for a 60GHz PA as an integrated CMOS solution. Operating from a 1V supply, it achieves a 1dB compressed output power of +9dBm and saturated power of +12.3dBm. The chip occupies an area of only 660×380µm2 by taking
Rapid radiofrequency field mapping in vivo using single‐shot STEAM MRI (2008)

Higher field strengths entail less homogeneous RF fields. This may influence quantitative MRI and MRS. A method for rapidly mapping the RF field in the human head with minimal distortion was developed on the basis of a single-shot stimulated echo acquisition mode (STEAM) sequence. The flip angle of the second RF pulse in the STEAM preparation was set to 60 degrees and 100 degrees instead of 90 degrees , inducing a flip angle-dependent signal change. A quadratic approximation of this trigonometric signal dependence together with a calibration accounting for slice excitation-related bias allowed for directly determining the RF field from the two measurements only. RF maps down to the level of the medulla could be obtained in less than 1 min and registered to anatomical volumes by means of the T(2)-weighted STEAM images. Flip angles between 75% and 125% of the nominal value were measured in line with other methods.
Fiber-optic evanescent wave sensor for gas detection (1994)

A novel fiber-optic evanescent wave sensor is presented. The sensor, composed of a lead salt tunable infrared laser and a multimode uncladded silver halide infrared optic fiber, was used for rapid measurement of sulfur hexafluoride pressures at a few-percent detection limit. High-precision detection and identification of a large variety of gases are possible.
Effects of ileal resection on biliary lipids and bile acid composition in patients with Crohn's disease. (1991)

Biliary lipid composition, cholesterol saturation, and bile acid pattern were determined in fasting duodenal bile of 10 patients (four men and six women, mean age 41 years) with Crohn's disease and a history of ileal resection (mean 64 cm). The data were compared with corresponding values in a group of healthy subjects. None of the patients with Crohn's disease had supersaturated bile. Cholesterol saturation was significantly lower in the patients with Crohn's disease than in the healthy subjects. The molar percentage of cholesterol was also lower among the patients but there was no significant difference. The molar percentages of phospholipids and bile acids were normal. Bile acid composition in the patients with ileal resection was characterised by a significant decrease in the deoxycholic acid fraction and a pronounced increase in the ursodeoxycholic acid fraction compared with the healthy subjects. The surprisingly high percentage of ursodeoxycholic acid may contribute to the low degree of cholesterol saturation in bile. Based on these results patients with Crohn's disease should not have an increased risk of cholesterol gall stone formation.
Shrinking microbubbles with microfluidics: mathematical modelling to control microbubble sizes (2017)

Microbubbles have applications in industry and life-sciences. In medicine, small encapsulated bubbles (<10 μm) are desirable because of their utility in drug/oxygen delivery, sonoporation, and ultrasound diagnostics. While there are various techniques for generating microbubbles, microfluidic methods are distinguished due to their precise control and ease-of-fabrication. Nevertheless, sub-10 μm diameter bubble generation using microfluidics remains challenging, and typically requires expensive equipment and cumbersome setups. Recently, our group reported a microfluidic platform that shrinks microbubbles to sub-10 μm diameters. The microfluidic platform utilizes a simple microbubble-generating flow-focusing geometry, integrated with a vacuum shrinkage system, to achieve microbubble sizes that are desirable in medicine, and pave the way to eventual clinical uptake of microfluidically generated microbubbles. A theoretical framework is now needed to relate the size of the microbubbles produced and the system's input parameters. In this manuscript, we characterize microbubbles made with various lipid concentrations flowing in solutions that have different interfacial tensions, and monitor the changes in bubble size along the microfluidic channel under various vacuum pressures. We use the physics governing the shrinkage mechanism to develop a mathematical model that predicts the resulting bubble sizes and elucidates the dominant parameters controlling bubble sizes. The model shows a good agreement with the experimental data, predicting the resulting microbubble sizes under different experimental input conditions. We anticipate that the model will find utility in enabling users of the microfluidic platform to engineer bubbles of specific sizes.
High‐mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair (2017)

A single protein, HMGB1, directs the triggering of inflammation, innate and adaptive immune responses, and tissue healing after damage. HMGB1 is the best characterized damage-associated molecular pattern (DAMP), proteins that are normally inside the cell but are released after cell death, and allow the immune system to distinguish between antigens that are dangerous or not. Notably, cells undergoing severe stress actively secrete HMGB1 via a dedicated secretion pathway: HMGB1 is relocated from the nucleus to the cytoplasm and then to secretory lysosomes or directly to the extracellular space. Extracellular HMGB1 (either released or secreted) triggers inflammation and adaptive immunological responses by switching among multiple oxidation states, which direct the mutually exclusive choices of different binding partners and receptors. Immune cells are first recruited to the damaged tissue and then activated; thereafter, HMGB1 supports tissue repair and healing, by coordinating the switch of macrophages to a tissue-healing phenotype, activation and proliferation of stem cells, and neoangiogenesis. Inevitably, HMGB1 also orchestrates the support of stressed but illegitimate tissues: tumors. Concomitantly, HMGB1 enhances the immunogenicity of mutated proteins in the tumor (neoantigens), promoting anti-tumor responses and immunological memory. Tweaking the activities of HMGB1 in inflammation, immune responses and tissue repair could bring large rewards in the therapy of multiple medical conditions, including cancer.
Investigation by Enzyme-Linked Immunosorbent Assay of <i>Salmonella</i> H Antigen-Antibody Reactions (1985)

An indirect enzyme-linked immunosorbent assay has been used for the detection of Salmonella group H antibodies.
Pharmacological small molecules for the treatment of lysosomal storage disorders (2010)

pharmacological small molecules are a new class of agents that show great promise for the treatment of lysosomal storage disorders.
Extending Sensing Capabilities and Modalities of Mobile Devices (2014)

Thesis (Ph.D.)--University of Washington, 2014
Pharmacokinetics of ibuprofen following a single administration of a suspension containing enteric-coated microcapsules. (1995)

The relative bioavailability of ibuprofen (CAS 15687-27-1) was investigated following a single administration of a suspension containing enteric-coated microcapsules (A) in comparison to a rapid-release film-coated tablet (B) and a sustained-release tablet (C). The study was carried out in a three-way crossover design in 9 healthy male volunteers. Each formulation contained 800 mg ibuprofen. Plasma concentrations of ibuprofen were determined with a specific HPLC method. A mean relative bioavailability of 0.96 (B) and 1.01 (C) was determined for the test formulation. Since the corresponding 90% confidence intervals were within the recommended limits, bioequivalence for the extent of bioavailability of the test formulation can be concluded. Differences in pharmacokinetics were observed for the rate-dependent parameters. For the test formulation, the highest mean maximum plasma concentration (54.3 micrograms/ml) was measured with a corresponding tmax of 1.9 h. For the reference formulations, mean peak plasma concentrations of 45.2 micrograms/ml after 2.6 h (B) and 25.7 micrograms/ml after 5.6 h (C) were observed. Despite the enteric coating of the microcapsules, a very short lagtime of 0.03 h was determined for the suspension. For the other rapid release formulation (B), the lagtime was in a similar magnitude (0.11 h), while the absorption from the sustained-release tablet was clearly decelerated (tlag = 0.97 h). In comparison to the other rapid-release formulation (B), significant higher amounts of the drug were absorbed from the test formulation (A) within the first hour.
Percent Free Base Nicotine in the Tobacco Smoke Particulate Matter of Selected Commercial and Reference Cigarettes (2003)

The available evidence suggests that most of the nicotine in mainstream tobacco smoke is in the smoke particle matter (PM) phase. Nicotine can exist in protonated and free base forms in the smoke PM, and alpha(fb) is the fraction of the PM nicotine that is in the free base form. Because only the free base form can volatilize from the smoke PM phase to the gas phase of an inhaled aerosol and because gaseous nicotine deposits rapidly in the respiratory tract (RT), the magnitude and rate of nicotine deposition in the RT will depend on alpha(fb). The types of values that alpha(fb) can assume in the PM of cigarette smoke aerosols have not been well-known. The conventional view has been that mainstream cigarette smoke PM contains relatively little free base nicotine so that the cigarette smoker must absorb nicotine mostly from deposited particles. A prior study concluded that because cigarette smoke is at "pH 5.3", there is very little free base nicotine in such smoke. A 1994 internal tobacco company document discusses the view that "smoke pH" values for cigarette smoke are "approximately 6.0". This work uses volatility-based measurements to provide determinations of equilibrium nicotine alpha(fb) values for mainstream smoke PM from selected cigarettes. The effective pH (i.e., pH(eff)) of the smoke PM from selected brands of commercial cigarettes was found to span a range of 6.0-7.8 (nicotine alpha(fb) = 0.01-0.36), with all pH(eff) values much larger than 5.3 and most larger than 6.0.
State of the art in parallel search techniques for discrete optimization problems (1999)

Discrete optimization problems arise in a variety of domains, such as VLSI design, transportation, scheduling and management, and design optimization. Very often, these problems are solved using state space search techniques. Due to the high computational requirements and inherent parallel nature of search techniques, there has been a great deal of interest in the development of parallel search methods since the dawn of parallel computing. Significant advances have been made in the use of powerful heuristics and parallel processing to solve large-scale discrete optimization problems. Problem instances that were considered computationally intractable only a few years ago are routinely solved currently on server-class symmetric multiprocessors and small workstation clusters. Parallel game-playing programs are challenging the best human minds at games like chess. In this paper, we describe the state of the art in parallel algorithms used for solving discrete optimization problems. We address heuristic and nonheuristic techniques for searching graphs as well as trees, and speed-up anomalies in parallel search that are caused by the inherent speculative nature of search techniques.
Lean-Agile Software Development: Achieving Enterprise Agility (2009)

Agile techniques have demonstrated immense potential for developing more effective, higher-quality software. However,scaling these techniques to the enterprise presents many challenges. The solution is to integrate the principles and practices of Lean Software Development with Agiles ideology and methods. By doing so, software organizations leverage Leans powerful capabilities for optimizing the whole and managing complex enterprise projects. A combined Lean-Agile approach can dramatically improve both developer productivity and the softwares business value.In this book, three expert Lean software consultants draw from their unparalleled experience to gather all the insights, knowledge, and new skills you need to succeed with Lean-Agile development. Lean-Agile Software Development shows how to extend Scrum processes with an Enterprise view based on Lean principles. The authors present crucial technical insight into emergent design, and demonstrate how to apply it to make iterative development more effective. They also identify several common development anti-patterns that can work against your goals, and they offer actionable, proven alternatives. Lean-Agile Software Development shows how to Transition to Lean Software Development quickly and successfully Manage the initiation of product enhancements Help project managers work together to manage product portfolios more effectively Manage dependencies across the software development organization and with its partners and colleagues Integrate development and QA roles to improve quality and eliminate waste Determine best practices for different software development teams The books companion Web site, www.netobjectives.com/lasd, provides updates, links to related materials, and supportfor discussions of the books content.
Routing without routes (2010)

Current data collection protocols for wireless sensor networks are mostly based on quasi-static minimum-cost routing trees. We consider an alternative, highly-agile approach called backpressure routing, in which routing and forwarding decisions are made on a per-packet basis. Although there is a considerable theoretical literature on backpressure routing, it has not been implemented on practical systems to date due to concerns about packet looping, the effect of link losses, large packet delays, and scalability. Addressing these concerns, we present the Backpressure Collection Protocol (BCP) for sensor networks, the first ever implementation of dynamic backpressure routing in wireless networks. In particular, we demonstrate for the first time that replacing the traditional FIFO queue service in backpressure routing with LIFO queues reduces the average end-to-end packet delays for delivered packets drastically (75% under high load, 98% under low load). Further, we improve backpressure scalability by introducing a new concept of floating queues into the backpressure framework. Under static network settings, BCP shows a more than 60% improvement in max-min rate over the state of the art Collection Tree Protocol (CTP). We also empirically demonstrate the superior delivery performance of BCP in highly dynamic network settings, including conditions of extreme external interference and highly mobile sinks.
A Robust, Blind and Imperceptible Watermarking of 3D Mesh Models Base on Redundancy Information (2012)

This paper proposes a robust, blind and imperceptible watermarking algorithm of 3D mesh models using redundancy information. The basic idea is to embed watermarks into a 3D mesh model by adjusting the order of vertexes in each triangle. Furthermore, we need to keep the normal vertex of each triangle unchanged. The algorithm is applied to many mesh models. Experimental results show no distortion will be caused and the imperceptibility of the watermark is very good. And its robustness against the common attacks, such as translation, rotation, scaling, noising, smoothing.
Glyphosate-Resistant Crops and Weeds: Now and in the Future (2009)

Glyphosate-resistant (GR) crops represent more than 80% of the 120 million ha of transgenic crops grown annually worldwide. GR crops have been rapidly adopted in soybean, maize, cotton, canola, and sugarbeet in large part because of the economic advantage of the technology, as well as the simple and superior weed control that glyphosate delivers. Furthermore, the GR crop/glyphosate technology is generally more environmentally benign than the weed management technologies that it replaced. In the Americas, except for Canada, adoption has meant continuous and intense selection pressure with glyphosate, resulting in evolution of GR weeds and shifts to weed species that are only partially controlled by glyphosate. This development is jeopardizing the benefits of this valuable technology. New transgenic crops with resistance to other herbicide classes -- in some cases coupled with glyphosate resistance -- will be introduced soon. If used wisely, these tools can be integrated into resistance management and prevention strategies. Greater diversity in weed management technologies is badly needed to preserve the utility of the GR crop/ glyphosate technology.
Wireless Mesh Networks for In-Home IPTV Distribution (2008)

IPTV is considered to be the next killer application. A key, challenging issue is in-home IPTV distribution with affordable deployment cost and sufficient flexibility, scalability, and reliability. In this article, we first survey and compare the emerging wired and wireless communication technologies for broadband home networks, including transmission over power lines, phone lines, coaxial cables or Ethernet cables, and IEEE 802.1 In, ultra wideband and millimeter wave wireless technologies. Considering these promising candidates for future broadband home networks, we propose three wireless mesh network architectures. These enable consumers to enjoy anywhere, anytime IPTV services without rewiring their homes. We compare the cost, reliability, and scalability of the three architectures. We further study their admission regions for IPTV, that is, the number of IPTV connections that can be supported simultaneously with satisfactory QoS. Analytical and simulation results with H.264 HDTV sources over wired, single hop wireless, and multi-hop wireless paths are given. These results can provide important guidelines for future broadband home network design supporting IPTV services.
Cradle Image Correction Method for CT Scout Scan Based on Image Registration (2006)

In scout scan of computer tomography(CT),the limited cradle quality imposes a limit on the clinical CT scan.For this reason,a digital subtraction method based on image registration technology was presented.First,the cradle only image was projected to the plane at the height of object image through affine transformation.Second,the vertical characteristics of cradle in both cradle only and cradle with patient images were extracted by using Sobel operator and then registrated.Finally,the cradle image was subtracted from the cradle with patient images.The results of simulation demonstrate the efficiency of this method.
The elastic modulus of columnar-grain fresh-water ice (1994)

An analysis is presented of stress and strain measurements made during an investigation of the characteristics of cracks formed in columnar-grain, type S2 fresh-water ice, during uniaxial, compressive loading at the nominal strain rates of 10 −3 , 10 −4 and 10 −5 s −1 , and temperatures of −5°, −10°, −20° and −30°C. The analysis shows that for this range of strain rate and temperature, ice behaves as an anelastic solid. Results are given for the time, grain-size and temperature dependence of the elastic modulus in the plane perpendicular to the long direction of the grains. They are shown to be in reasonable agreement with results of an earlier study of the anelastic behaviour of the same type of ice. It is suggested that the grain-size and temperature dependence of the elastic moduli of ice for this range of strain rate and temperature may be due, in part, to the dependence of the relaxation time on these variables.
Tourette's syndrome: a cross sectional study to examine the PANDAS hypothesis (2003)

The results support a role of group A streptococcal infection and basal ganglia autoimmunity in a subgroup of patients with Tourette's syndrome and suggest a pathogenic similarity between Sydenham's chorea and some patients with Tourette's syndrome.