gebhart/patrepeval huggingface dataset:
Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinico-pathological parameters (2004)

Increased COX-2 expression in the endometriotic ovarian cyst wall was observed with respect to other extraovarian localizations. No relevant correlations between COX-2 positivity and clinico-pathological characteristics and symptoms of patients were observed.
Distribution of the hematozoa of Neotropical birds. (1978)

The literature pertaining to the prevalence of avian hematozoa in the Neotropics, together with unpublished records from the files of the International Reference Centre for Avian Haematozoa, has been examined with respect to the distribution of parasite genera by host family and region. The blood parasites of 35555 birds of 955 species (80 families) occurring in the Neotropics formed the basis for the comparisons. Only 3743 (10.5%) individuals harbored one or more species of hematozoa. Haemoproteus was the most commonly observed form exhibiting a 7.4% prevalence, followed by Plasmodium (1.9%), microfilaria (1.2%), Trypanosoma (0.6%), and Leucocytozoon (0.2%). Hematozoan prevalence varied markedly from region to region and among families. In comparison with a similar review of Nearctic avian hematozoan distribution, the Neotropics demonstrated a much lower prevalence and a near absence of Leucocytozoon.
Recognition of Arabic Sign Language Alphabet Using Polynomial Classifiers (2005)

Building an accurate automatic sign language recognition system is of great importance in facilitating efficient communication with deaf people. In this paper, we propose the use of polynomial classifiers as a classification engine for the recognition of Arabic sign language (ArSL) alphabet. Polynomial classifiers have several advantages over other classifiers in that they do not require iterative training, and that they are highly computationally scalable with the number of classes. Based on polynomial classifiers, we have built an ArSL system and measured its performance using real ArSL data collected from deaf people. We show that the proposed system provides superior recognition results when compared with previously published results using ANFIS-based classification on the same dataset and feature extraction methodology. The comparison is shown in terms of the number of misclassified test patterns. The reduction in the rate of misclassified patterns was very significant. In particular, we have achieved a 36% reduction of misclassifications on the training data and 57% on the test data.
Estrogenicity of the Isoflavone Metabolite Equol on Reproductive and Non-Reproductive Organs in Mice1 (2004)

Equol, a metabolite of the phytoestrogen daidzein, is present at significant levels in some humans who consume soy and in rodents fed soy-based diets. Equol is estrogenic in vitro, but there have been limited studies of its activity in vivo. We evaluated equol effects on reproductive and non-reproductive endpoints in mice. Ovariectomized age-matched (30-day-old) female C57BL/6 mice were fed phytoestrogen-free diets and given a racemic mixture of equol by daily injections (0, 4, 8, 12, or 20 mg [kg body weight](-1) day(-1)) or in the diet (0, 500, or 1,000 ppm) for 12 days. Mice were killed, and serum concentrations of total and aglycone equol were measured. Total serum equol concentrations ranged from 1.4 to 7.5 microM with increasing doses of injected equol, but uterine weight increased significantly only at 12 and 20 mg (kg body weight)(-1) day(-1). Dietary equol at 500 or 1,000 ppm produced total serum equol concentrations of 5.9 and 8.1 microM, respectively, comparable with those in rodents consuming certain high-soy chows; the proportion of equol present as the free aglycone was much lower with dietary administration than injections, which may be a factor in the greater biological effects induced by injections. Dietary equol did not significantly increase uterine weight. Increasing dietary and injected equol doses caused a dose-dependent increase in vaginal epithelial thickness. Uterine epithelial proliferation was increased by equol injections at 8-20 mg (kg body weight)(-1) day(-1) and 1,000 ppm dietary equol. Neither dietary nor injected equol decreased thymic or adipose weights. In conclusion, equol is a weak estrogen with modest effects on endpoints regulated by estrogen receptor alpha when present at serum levels seen in rodents fed soy-based diets, but quantities present in humans may not be sufficient to induce estrogenic effects, although additive effects of equol with other phytoestrogens may occur.
Efficient PA Modeling Using Neural Network and Measurement Setup for Memory Effect Characterization in the Power Device (2005)

This paper proposes a new artificial neural network (ANN) model for power amplifiers (PAs), which exhibits memory effects. This model is based on a complex-valued multilayered perceptron (MLP) time delay neural network (TDNN). The developed PA models are based on TDNN with unity and non-uniform time delay taps between instantaneous and previous input signal of the PA. Modeling results for both types of PA models will be compared to show the advantage of the newly developed model. Furthermore, a new measurement setup for analyzing and measuring the nonlinearity and memory effects in GaN active power device is also proposed.
Maximization of conversion efficiency based on global normal irradiance using hybrid concentrator photovoltaic architecture (2016)

Abstract Maximization of module conversion efficiency based on global normal irradiance (GNI) rather than direct normal irradiance (DNI) was experimentally demonstrated using a hybrid concentrator photovoltaic (CPV) architecture in which a low‐cost solar cell (a bifacial crystalline silicon cell) was integrated with a high‐efficiency concentrator solar cell (III–V triple‐junction cell) to harvest diffuse sunlight. The results of outdoor experiments showed that the low‐cost cell enhanced the generated power by factors of 1.39 and 1.63 for high‐DNI and midrange‐DNI conditions, respectively, and that the resultant GNI‐based module efficiencies were 32.7% and 25.6%, respectively. © 2016 The Authors. Progress in Photovoltaics: Research and Applications published by John Wiley & Sons Ltd.
Isolation and characterization of iron-independent positive dominant mutants of the diphtheria toxin repressor DtxR (1998)

It is well known that the functional activity of the diphtheria toxin repressor DtxR is controlled by iron, which serves as an essential cofactor necessary for activation of target DNA binding by this regulatory element. In this communication, we describe the isolation and characterization of a unique series of DtxR mutants that are constitutively active and repress the expression of beta-galactosidase from a diphtheria tox promoter/operator-lacZ transcriptional fusion, even in the absence of iron. These self-activating mutants of DtxR (SAD) were isolated through the use of a positive selection system for the cloning of functional dtxR alleles and target DNA operator sites. Of the four independently isolated SAD mutants that were characterized, two (SAD2 and SAD11) were found to carry a single missense mutation (E175K) in their respective C-terminal SH3-like domains. In contrast, the mutant allele encoding SAD3 was found to carry a total of six missense mutations distributed throughout the N- and C-terminal domains of the repressor. Partial diploid analysis of strains carrying both native dtxR and alleles encoding either SAD2 or SAD3 demonstrate that these iron-independent mutants possess a positive dominant phenotype in the regulation of beta-galactosidase expression from a diphtheria tox promoter/operator-lacZ transcriptional fusion.
Deposition of bioactive human epidermal growth factor in the egg white of transgenic hens using an oviduct‐specific minisynthetic promoter (2015)

Currently, transgenic animals have found a wide range of industrial applications and are invaluable in various fields of basic research. Notably, deposition of transgene-encoded proteins in the egg white (EW) of hens affords optimal production of genetically engineered biomaterials. In the present study, we developed a minisynthetic promoter modulating transgene transcription specifically in the hen's oviduct, and assayed the bioactivity of human epidermal growth factor (hEGF) driven by that promoter, after partial purification of epidermal growth factor (EGF) from transgenic hen eggs. Our minisynthetic promoter driving expression of chicken codon-optimized human epidermal growth factor (cEGF) features 2 consecutive estrogen response elements of the ovalbumin (OV) promoter, ligated with a 3.0 kb OV promoter region carrying OV regulatory elements, and a 5'-UTR. Subsequently, a 3'-UTR carrying the poly-A tail sequence of the OV gene was added after incorporation of the cEGF transgene. Finally, we partially purified cEGF from transgenic hen eggs and evaluated the biofunctional activities thereof in vitro and in vivo. In the in vitro assay, EW-derived hEGF exhibited a proliferative effect on HeLa cells similar to that of commercial hEGF. In the in vivo assay, compared to the nontreated control, transgenic hen egg-derived EGF afforded slightly higher levels of re-epithelialization (via fibroplasia) and neovascularization of wounded skin of miniature pigs than did the commercial material. In conclusion, transgenic hens may be used to produce genetically engineered bioactive biomaterials driven by an oviduct-specific minisynthetic promoter.
Modeling and simulation of folding-boom aerial platform vehicle based on the flexible multi-body dynamics (2010)

Folding-boom aerial platform vehicle is a type of construction vehicle used to hoist personnel to the appointed location in the aerial. As for aerial platform vehicle, the flexible deformations of the arm system cannot be neglected. Therefore, the flexible multi-body dynamics equations of the arm system of folding-boom aerial platform vehicle are established based on flexible multi-body dynamics theory and Lagrange's equation. Following, the simulation is carried out. The simulation results show that the moving beams exist high frequency vibrations, which caused by the elastic deformations of them. As a result, the vibrations cause the work platform of aerial platform vehicle to shake, and at the same time, the deflections of the beams lead to small deviations of the trajectory of the work platform. Therefore, the establishment of the equations lays the basis of vibration controlling and accurately controlling the trajectory of the work platform of aerial platform vehicle.
Cardiovascular prognosis of sustained and white-coat hypertension in patients with type 2 diabetes mellitus (2008)

The cardiovascular prognosis for diabetic WCH was better than that for diabetic SH during 4 years of follow-up.
Stereocorrelation of Landsat TM images (1987)

A digital elevation model (DEM) developed from Landsat TM images of a rugged terrain area in north Georgia by automated stereocorrelation techniques yielded an rms error (z), RMSE(z), value of + or - 42 m. Based on the B/H ratio of 0.18 for the Landsat data, this Z-error corresponds to a planimetric correlation accuracy of about + or - 0.3 pixels, confirming that precise correlation can be achieved with operational satellite data. Contours at a 100-m interval interpolated from the DEM show a deviation of + or - 33 m from reference contours obtained from existing 1:24,000-scale maps. The 28.5-m pixel resolution and the weak B/H ratio impose limitations on the accuracy that can be achieved with Landsat TM data. However, it is anticipated that RMSE(z) values of + or - 10 m or less can be achieved with SPOT-1 panchromatic stereo images of 10-m resolution recorded at B/H ratios of 0.5 to 1.0. DEMs generated by stereocorrelation techniques can be used to create orthoimages, perspective views, and topographic map products.
Electron-event representation data enable efficient cryoEM file storage with full preservation of spatial and temporal resolution (2020)

Direct detector device (DDD) cameras have revolutionized electron cryomicroscopy (cryoEM) with their high detective quantum efficiency (DQE) and output of movie data. A high ratio of camera frame rate (frames per second) to camera exposure rate (electrons per pixel per second) allows electron counting, which further improves the DQE and enables the recording of super-resolution information. Movie output also allows the correction of specimen movement and compensation for radiation damage. However, these movies come at the cost of producing large volumes of data. It is common practice to sum groups of successive camera frames to reduce the final frame rate, and therefore the file size, to one suitable for storage and image processing. This reduction in the temporal resolution of the camera requires decisions to be made during data acquisition that may result in the loss of information that could have been advantageous during image analysis. Here, experimental analysis of a new electron-event representation (EER) data format for electron-counting DDD movies is presented, which is enabled by new hardware developed by Thermo Fisher Scientific for their Falcon DDD cameras. This format enables the recording of DDD movies at the raw camera frame rate without sacrificing either spatial or temporal resolution. Experimental data demonstrate that the method retains super-resolution information and allows the correction of specimen movement at the physical frame rate of the camera while maintaining manageable file sizes. The EER format will enable the development of new methods that can utilize the full spatial and temporal resolution of DDD cameras.
Comparing Policy-Gradient Algorithms (2001)

We present a series of formal and empirical results comparing the efficiency of various policy-gradient methods—methods for reinforcement learning that directly update a parameterized policy according to an approximation of the gradient of performance with respect to the policy parameter. Such methods have recently become of interest as an alternative to value-function-based methods because of superior convergence guarantees, ability to find stochastic policies, and ability to handle large and continuous action spaces. Our results include: 1) formal and empirical demonstrations that a policy-gradient method suggested by Sutton et al. (2000) and Konda and Tsitsiklis (2000) is no better than RE-INFORCE, 2) derivation of the optimal baseline for policy-gradient methods, which differs from the widely used V π (s) previously thought to be optimal, 3) introduction of a new all-action policy-gradient algorithm that is unbiased and requires no baseline, and demonstrating empirically and semi-formally that it is more efficient than the methods mentioned above, and 4) an overall comparison of methods on the mountain-car problem including value-function-based methods and bootstrapping actor-critic methods. One general conclusion we draw is that the bias of conventional value functions is a feature, not a bug; it seems required is order for the value function to significantly accelerate learning.
Leaf Proteins as Foodstuffs, Amino Acid Composition of Leaf Protein Concentrates (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLeaf Proteins as Foodstuffs, Amino Acid Composition of Leaf Protein ConcentratesE. D. Gerloff, I. H. Lima, and M. A. StahmannCite this: J. Agric. Food Chem. 1965, 13, 2, 139–143Publication Date (Print):March 1, 1965Publication History Published online1 May 2002Published inissue 1 March 1965https://pubs.acs.org/doi/10.1021/jf60138a012https://doi.org/10.1021/jf60138a012research-articleACS PublicationsRequest reuse permissionsArticle Views377Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of acute carnitine administration on glucose insulin metabolism in healthy subjects. (1997)

The authors evaluated the effect of carnitine on glucose insulin metabolism. Twenty-five subjects free from metabolic disorders or serious functional alterations in the liver, kidneys or myocardium were studied. All were infused with a 5% glucose-enriched solution (Group A); 48 h later the same subjects were infused with a 5% glucose solution containing 2g carnitine (Group B). Variations in blood glucose and insulin levels and range were measured at different times during and after infusion. Study results showed that the administration of carnitine lead to an improvement in glucose metabolism, as demonstrated by a saving in insulin secretion accompanied, at least on a temporary basis, by a corresponding decrease in blood glucose which, however, remained within normal parameters.
Module generator of data recovery for serial link receiver (2004)

A module generator for the all-digital data recovery of a highspeed serial link, using an oversampling method, is proposed. The architecture of the proposed method is very regular and hence very suitable for standard cell implementation flow, which also makes it very suitable as a soft silicon intellectual property. This module generator can automatically generate the design parameters to deal with the oversampling architecture to meet different specifications. A design example, generated by the module generator, is implemented by using the TSMC 0.35 /spl mu/m 1P4M cell library. The maximum performance of the design (without extra pipelining stages) can reach 2.09 Gbps with power consumption of 112.2 mW at 3.3 V.
Different Changes in Protein and Phosphoprotein Levels Result from Serum Starvation of High-Grade Glioma and Adenocarcinoma Cell Lines (2009)

Tumor cells undergoing serum starvation in vitro partially mimic metabolically stressed cells trying to adjust to a changed environment in vivo by inducing signal transduction and gene expression so that the tumor continues to grow. Our hypothesis is that the changes in protein and phosphoprotein levels after serum starvation may reflect the adapted phenotype of the tumor, which could be targeted for therapy. We used reverse-phase protein microarrays to interrogate five high-grade glioma cell lines and seven adenocarcinoma cell lines for differences in the level of 81 proteins and 25 phosphoproteins. All cell lines were studied in the well-fed condition of growth with 10% FBS and the starved condition of 0.5% FBS. Protein expression levels were normalized to beta-actin and trichotomized as increased (+1, upper 75th quartile), decreased (-1, lowest 25th quartile), or unchanged (0, others) to focus on the patterns of the biggest (and hopefully most robust) changes in protein and phosphoprotein levels. We examined these trichotomized values to better understand Starved-Fed differences among the cell lines and thereby gain better/clearer insight into the effects of serum starvation on potential cellular responses. In general, the expression of proteins and phosphoproteins 24 h after FBS starvation increased more often in glioma lines than in adenocarcinoma lines, which appeared to have fewer increased protein scores and more decreased scores. Many of the proteins increased in gliomas were downstream targets of the PTEN-PI-3 kinase-AKT, EGFR-MAPK-Stat, and transcription activator-polyamine signaling pathways. In adenocarcinomas, the expression of proteins and phosphoproteins generally increased in apoptosis pathways, while there were minor fluctuations in the other pathways above. Contrawise, gliomas become resistant to apoptosis after 24 h of serum starvation and upregulate transcription activators and polyamines more so than adenocarciomas.
Scheduling periodic and aperiodic tasks in hard real-time computing systems (1991)

Scheduling periodic and aperiodic tasks to meet their time constraints has been an important issue in the design of real-time computing systems. Usually, the task scheduling algorithms in such systems must satisfy the deadlines of periodic tasks and provide fast response times for aperiodic tasks. A simple and efficient approach to scheduling real-time tasks is the use of a periodic server in a static preemptive scheduling algorithm. Periodic tasks, including the server, are scheduled at priori to meet their deadlines according to the knowledge of their periods and computation times. The scheduling of aperiodic tasks is then managed by the periodic server during its service time. In this paper, a new scheduling algorithm is proposed. The new algorithm creates a periodic server which will have the highest priority but not necessarily the shortest period. The server is suspended to reduce the overhead if there are no aperiodic tasks waiting, and is activated immediately upon the arrival of the next aperiodic task. After activated, the server performs its duty periodically until all waiting aperiodic tasks are completed. For a set of tasks scheduled by this algorithm, the deadlines of periodic tasks are guaranteed by a deterministic feasibility check, and the mean response time of aperiodic tasks are estimated using a queueing model. Based on the analytical results, we can determine the period and service time of the server producing the minimum mean response time for aperiodic tasks. The analytical results are compared with simulation results to demonstrate the correctness of our model.
Activation of reducing agents. Sodium hydride containing complex reducing agents. 20. Pdc, a new, very selective heterogeneous hydrogenation catalyst (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTActivation of reducing agents. Sodium hydride containing complex reducing agents. 20. Pdc, a new, very selective heterogeneous hydrogenation catalystJean Jacques Brunet and Paul CaubereCite this: J. Org. Chem. 1984, 49, 21, 4058–4060Publication Date (Print):October 1, 1984Publication History Published online1 May 2002Published inissue 1 October 1984https://doi.org/10.1021/jo00195a037Request reuse permissionsArticle Views447Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (423 KB) Get e-Alertsclose Get e-Alerts