gebhart/patrepeval huggingface dataset:
Intracoronary KAI-9803 as an Adjunct to Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction (2008)

KAI-9803 had an acceptable safety and tolerability profile when delivered via intracoronary injection during primary percutaneous coronary intervention for ST-segment elevation MI. Signs of potential drug activity were demonstrated with biomarker end points in this small exploratory study, indicating that further testing of KAI-9803 as an adjunctive therapy for ST-segment elevation MI is warranted.
Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of <i>Schistosoma mansoni</i> . (1993)

Granulomas induced by parasite eggs are the primary lesions in mice infected with Schistosoma mansoni. Temporal analysis of cytokine mRNA expression in lung tissue containing synchronized granulomas demonstrated a Th0-like pattern of lymphokine expression. IFN-gamma, IL-1 beta, and IL-6 were the primary cytokines induced by day 1 in developing lung granulomas initiated by i.v. egg injection. These changes were followed by increases in expression of IL-2, IL-4, and IL-10 mRNA on day 3 and TNF-alpha and IL-5 mRNA on day 6. Nearly all cytokine mRNA reached maximal levels by day 6, which preceded the peak in granuloma size seen on day 14. In vivo treatment of egg-injected mice with either anti-IL-2 or anti-IL-4 antibodies significantly diminished the size of circumoval granulomas in the lungs. Both groups of antibody-treated animals displayed a marked reduction in IL-4 as well as IL-5 mRNA expression, although IFN-gamma and IL-2 mRNA levels were unchanged or slightly increased. These findings confirm previous observations suggesting a role for IL-2 in egg-induced pathology via the generation of Th2-associated responses, and also indicate a primary function for IL-4 in granuloma formation. Analysis of responses after injection of eggs into nude mice demonstrated that only the Th2 cytokines IL-4 and IL-5 are exclusively dependent on T cells for their induction. Taken together, these data suggest that Th2 cells producing IL-4 play a major role in egg granuloma formation, and that the induction and ultimate down-modulation of Th2-like responses may be influenced by non-T-cell-derived cytokines.
Randomization tests for distinguishing social influence and homophily effects (2010)

Relational autocorrelation is ubiquitous in relational domains. This observed correlation between class labels of linked instances in a network (e.g., two friends are more likely to share political beliefs than two randomly selected people) can be due to the effects of two different social processes. If social influence effects are present, instances are likely to change their attributes to conform to their neighbor values. If homophily effects are present, instances are likely to link to other individuals with similar attribute values. Both these effects will result in autocorrelated attribute values. When analyzing static relational networks it is impossible to determine how much of the observed correlation is due each of these factors. However, the recent surge of interest in social networks has increased the availability of dynamic network data. In this paper, we present a randomization technique for temporal network data where the attributes and links change over time. Given data from two time steps, we measure the gain in correlation and assess whether a significant portion of this gain is due to influence and/or homophily. We demonstrate the efficacy of our method on semi-synthetic data and then apply the method to a real-world social networks dataset, showing the impact of both influence and homophily effects.
Feature linking via stimulus-evoked oscillations: experimental results from cat visual cortex and functional implications from a network model (1989)

Until recently, no known physiological mechanism could explain the transient linking of local visual features into global coherent percepts. The authors have found such principles at a 'computational stage' of preattentive processing in the cat's primary visual cortex. The results show that stimulus-evoked oscillations of local processing units, representing local visual features, are transiently locked into a common resonance state by an appropriate global stimulus. The experimental results suggest further that the activities of those neural groups that represent features that are to be linked in the current visual situation become synchronized. Synchronization was found among assemblies in a single cortex column (where similar local features are processed) and, more important, among remote assemblies of the same cortex area and even among assemblies in different areas when the assemblies share some common local visual features. These cortical linking features are considered to be the neural representations of the corresponding perceptual linking features.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Synthesis and biological activity of 6-alkyl/chloro-3-{4-(6-alkyl/chloro-2H-benzo[e][1,3]oxazin-3(4H)-yl)phenyl}-3,4-dihydro-2H-benzo[e][1,3]oxazines (2010)

The efficient synthesis of symmetrical bis-benzoxazines using microwave irradiation is described and the possibility of a multicomponernt approach to the target molecule has also been explored. The antimicrobial studies on the synthesized benzoxazines have been investigated.
Activation of the p21‐activated protein kinases from neutrophils with an antibody that reacts with the N‐terminal region of Pak 1 (1997)

Neutrophils contain two renaturable p21-activated protein kinases (Paks) with molecular masses of ca. 69 and 63 kDa that undergo rapid activation upon stimulation of these cells with the chemoattractant fMet-Leu-Phe. We now report that these kinases undergo a massive, ATP-dependent activation in lysates of unstimulated neutrophils during immunoprecipitation with an antibody generated to residues 2-21 of the N-terminal region of Pak1. This activation was specific as it was completely blocked by a peptide that corresponds to residues 2-21 of Pak1 and was not observed with an antibody generated to the C-terminal region of Pak 1. The properties of the Paks activated with the antibody were virtually identical to those observed for these kinases from stimulated neutrophils, or activated in vitro with Rac-GTPgammaS plus ATP. These data indicate that perturbation of the N-terminal region of Pak can trigger activation of this enzyme, and that both the 69 and 63 kDa kinases may represent forms of Pak 1 that differ in their content of phosphate.
Video segmentation of MPEG compressed data (2002)

An approach for parsing MPEG compressed video into shots and sub-shots based only on the macroblock (MB) and motion vector (MV) information is presented. The system follows a two-pass scheme and has a hybrid rule-based/neural structure. A rough scan over the P frames locates the potential shot boundaries and the solution is then refined by a precise scan over the B frames of the respective neighborhoods. The "simpler" boundaries are recognized by the rule-based module, while the decisions for the "complex" ones are refined by the neural part. The latter is also used to distinguish dissolves from object and camera motions and to break the shots into sub-shots. The experiments demonstrate high speed and accuracy in shot detection and their characterization.
Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice. (1982)

To determine the role of collagen-immunity in the development of collagen-induced arthritis, DBA/1 mice were immunized with type II collagen and observed for the development of polyarthritis. 96% of the mice immunized with native type II collagen developed inflammatory arthritis between 4 and 5 wk after primary immunization. Immunization with denatured type II collagen in exactly the same manner was not effective in inducing arthritis. Cell-mediated immunity in arthritic mice was assessed by measuring [3H]thymidine incorporation by mononuclear cells cultured in the presence of collagen. The maximal proliferative response to collagen occurred at 2 wk after immunization. Equally good incorporation of label occurred when cells were cultured with native or denatured type II collagen or type I collagen. The cellular response of nonarthritic mice immunized with denatured collagen was indistinguishable from that seen in arthritic mice. Humoral immunity was assessed by an ELISA assay for antibodies to collagen. The immunoglobulin M (IgM) response peaked at 2 wk and the IgG response at 5 wk after immunization. Antisera from arthritic mice immunized with native type II collagen were relatively specific for conformational determinants on the native type II molecule although some reactivity with denatured collagen was noted. Antisera from nonarthritic mice immunized with denatured collagen primarily recognized covalent structural determinants. It was concluded that native type II collagen was essential for the induction of arthritis and that an antibody response specific for native type II collagen may be important for the development of arthritis.
Mass Spectrometer Ionization Chamber (1957)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation James A. Rickard; Mass Spectrometer Ionization Chamber. Rev. Sci. Instrum. 1 November 1957; 28 (11): 967–968. https://doi.org/10.1063/1.1715783 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioReview of Scientific Instruments Search Advanced Search |Citation Search
A system of atypical catecholamine-containing nerve fibres in the rat iris present after total superior cervical ganglionectomy. (1980)

A system of hitherto unknown weakly fluorescent fibres was detected in the rat iris by Falck-Hillarp fluorescence histochemistry after superior cervical ganglionectomy. These long smooth winding (SW)-fibres had a scarce and unusual distribution, forming loops and meandering for long distances with limited branching. Pharmacological tests suggest that they store a catecholamine but differ from adrenergic nerves in lacking an efficient uptake mechanism for amines. SW-fibres reached all parts of the iris and gave rise to few scattered extremely faint green fluorescent, limited plexuses of irregularly bulgy fibres. Suggestions as to the cellular origin of the SW-fibres include the ciliary ganglion and the central nervous system.
Plasma Homocysteine Concentration and Its Relation to Symptoms of Vascular Disease in Psychogeriatric Patients (2005)

The high frequency of comorbidity of vascular disease and mental illness indicates a possibility to prevent and treat psychogeriatric disease by actively counteracting vascular disease in patients with psychogeriatric symptoms. Routine determination of NT-proBNP is valuable for obtaining information about cardiovascular status.
Incidence of Myopia in High School Students with and without Red-Green Color Vision Deficiency (2009)

Color vision deficiencies appear to influence the development of myopia. The observed lower incidence of myopia in people with CVD may be linked to the reduced functionality of the L/M chromatic mechanism.
CERN-PS Main Power Converter Renovation: How to Provide and Control the Large Flow of Energy for A Rapid Cycling Machine (2006)

The PS accelerator (Proton-Synchrotron) at CERN, which is part of the LHC injector chain, is composed of one hundred magnets connected in series. During a typical acceleration cycle (taking 2.4 seconds), the active power at the magnet terminals varies from plus to minus 40 MW. As this large active power variation was not acceptable to the electrical network, a motor-generator set (M-G) was inserted between the grid and the load. The M-G set (of 1968) acts as a fly-wheel with a stored kinetic energy of 233 MJ and the magnets are fed via two 12-pulse thyristor rectifiers. A renovation or replacement of the installation is planned in the near future as part of the consolidation of the LHC injectors to avoid any major breakdown, to improve overall availability and to reduce operation and maintenance costs. This paper presents a first comparison of technical solutions available to build such a power system and the strategy that will be applied for the up-grade of the system.
Usability testing for a computer skills WBT (Web based training) program (1999)

Web Based Training (WBT) courses are being used more and more to reach end users whose computer literacy skills need updating before using a software application or performing jobrelated tasks. These Internet or intranet computer based training modules can provide just-in-time (JIT) training that is individualized for each user, is highly interactive, and is available any time any place (ATAP.)
Chronic Intracerebroventricular Administration of Recombinant CART(42–89) Peptide Inhibits Food Intake and Causes Weight Loss in Lean and Obese Zucker (<i>fa/fa</i>) Rats (2000)

Due to obvious effects on motor behavior, it is impossible with certainty to conclude that the observed effects on feeding and body weight are primary interference with satiety centers or secondary to effects on locomotor pathways. Also, the present experiments suggest that hypothalamic appetite-regulating neurons are subject to pharmacological desensitization upon prolonged exposure to CART peptide. The underlying mechanism of such desensitization is as yet unknown.
Elevated Waste Anaesthetic Gas Concentration in the Paediatric Post-Anaesthesia Care Unit (2018)

Even in a modern recovery room constructed according to current building standard and code, ambient air levels of WAG exceed the recommendations. Future research and practice standards are needed to reduce this occupational exposure. Disregarding whether chronic exposure to WAG is harmful, we have shown that HCP working in recovery rooms are chronically exposed to concentrations which exceed recommended levels. Strategies are needed to reduce ambient levels of WAG in post-anaesthesia care units.
Zero-voltage switching in high frequency power converters using pulse width modulation (2003)

A zero-voltage switching technique is described that utilizes a resonant transition during a short but finite switching interval. This zero-voltage resonant-transition (ZVRT) switching technique can be applied to conventional buck, boost, and buck-boost power converter topologies that operate with a constant switching frequency and use pulsewidth modulation for output control. Since frequency-dependent losses are greatly reduced in the power transistors, efficient operation at higher switching frequencies (>1 MHz) is allowed. However, conduction losses are increased because ripple currents are increased and synchronous rectification is required. Experimental results are presented for an interleaved flyback converter that operates with ZVRT switching at 1 MHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Dimethyl-Celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-Inhibitory function, potently mimics the anti-tumor effects of celecoxib on burkitt’s lymphoma in vitro and in vivo (2005)

The nonsteroidal anti-inflammatory drug (NSAID) celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor that has shown some promising results as an anti-cancer drug. However, the question arose as to whether or not its COX-2-inhibitory function is required for its anti-tumorigenic properties. We therefore employed dimethyl-celecoxib (DMC), which is a close structural analog of celecoxib that lacks COX-2-inhibitory function, to investigate this question. By performing a combination of in vitro and in vivo studies with Burkitt's lymphoma cells, we found that DMC potently mimics all of the anti-proliferative and anti-tumorigenic effects of celecoxib. In cell culture, DMC effectively inhibits cell proliferation through the down-regulation of cyclins A and B and the ensuing loss of cyclin-dependent kinase activity. This effect appears to take place in vivo as well and results in significantly (p<.002) reduced tumor growth in experimental animals. Thus, our results demonstrate that the anti-proliferative and anti-tumorigenic properties of celecoxib and DMC are indistinguishable, at least in Burkitt's lymphoma cells, and therefore, that the COX-2-inhibitory function is not required for these effects.
Distributed Scalable Multi-player Online Game Servers on Peer-to-Peer Networks (2005)

Today's Multi-player Online Games (MOGs) are challenged by infrastructure requirements because of their server-centric nature. Peer-to-peer overlay networks are an interesting alternative if they can implement the set of functions that are traditionally performed by centric game servers. In this paper, we propose a Zoned Federation Model (ZFM) to adapt MOGs to peer-to-peer overlay networks. We also introduce the concept of zone and zone owner to MOGs. A zone is some part of the whole game world, and a zone owner is a game sever of a specific zone. According to the demands of the game program, each node actively changes its role to a zone owner. By dividing the whole game world into several zones, workloads of the centric game server can be distributed to a federation of zones. In order to reduce response latency overhead on data exchanges between a zone owner and its clients, we limit the use of a Distributed Hash Table(DHT) to the rendezvous point of each zone; actual data exchanges are carried out through direct TCP connection between a zone owner and its members. We also use the DHT as backup storage media to cope with the resignation of a zone owner. We have implemented this zoned federation model as a middle layer between the game program and the DHT, and we evaluate our implementation with a prototypical multi-player game. Evaluation results indicate that our approach enables game creators to design scalable MOGs on the peer-to-peer environment with a short response latency which is acceptable for MOGs.
Review—Recent Trends on the Electrochemical Sensors Used for the Determination of Tartrazine and Sunset Yellow FCF from Food and Beverage Products (2022)

Synthetic dyes were widely used in food industry due to their advantages such as good stability to oxygen, light and pH, reproducibility, bright color, low sensitivity to storage conditions and technological processing, and of course, low cost. Unfortunately, some of them have potential harmful effect to human health (the presence of azo group in the molecular structure of azo dyes has carcinogenic and mutagenic effects in the human health), thus, their detection in various food and beverage products became essential. Therefore, this review presents the latest development in sensors design used for the determination of two commonly used azo dyes—tartrazine and sunset yellow in real food and beverage samples, revealing that there is a variety of efficient sensors with low limits of detection, wide linear concentration ranges, high selectivities and sensitivities.
Design of a wind turbine-generator system considering the conformability to wind velocity fluctuations (1999)

The conformability of the rated power output of the wind turbine-generator system and of the wind turbine type to wind velocity fluctuations are investigated with a simulation model. The authors examine three types of wind turbines: the Darrieus-Savonius hybrid, the Darrieus proper and the Propeller. These systems are mainly operated at a constant tip speed ratio, which refers to a maximum power coefficient points. As a computed result of the net extracting power, the Darrieus turbine proper has little conformability to wind velocity fluctuations because of its output characteristics. As for the other turbines, large-scale systems do not always have an advantage over small-scale systems as the effect of its dynamic characteristics. Furthermore, it is confirmed that the net extracting power of the Propeller turbine, under wind direction fluctuation, is much reduced when compared with the hybrid wind turbine. Thus, the authors conclude that the appropriate rated power output of the system exists with relation to the wind turbine type for each wind condition.
Suppression of Herpes Simplex Virus Infection by Antimitotic Substances in the Rabbit Cornea (1971)

Colchicine, demecolcine, vinblastine, and vincristine were found to suppress infections of the cornea by a strain of herpes simplex virus in rabbits and of rabbit kidney tissue cultures. These agents were applied locally once every 24 hr for 1-4 or 1-10 days. The duration of treatment was limited by the necessity of avoiding the production of a glittering opacity of the cornea as a toxic manifestation of some of these agents. Because of its lower toxicity, deme-colcine was found to be the agent of choice for studies of the antiviral activities of anti-mitotic substances.
Extending Pearl for industrial real-time applications (1993)

High-Integrity Pearl, (HI-Pearl) an extension to the Process and Experiment Automation Real-Time language (Pearl) which incorporates several principles from the real-time Euclid language, is described. The requirements of real-time software and components of a real-time language are reviewed. HI-Pearl's mechanisms for concurrency control, synchronization, allocation, time-bounded loops, surveillance of events, parallelism, timing constraints, overload detection and handling, storage management, run tracing, and error detection and handling are discussed. HI-Pearl's schedulability analyzer, an automated tool to predict whether real-time software will adhere to its critical timing constraints, is also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>