gebhart/patrepeval huggingface dataset:
Cutting-Edge Materials Technology Elevates Drilling Performance in Soft-Formation Applications (2005)

Abstract Drill bits manufactured using the powder forge (PF) process rather than conventional welded hard metal are setting new standards for soft formation drilling. The PF process provides unique advantages in hardmetal placement and metallurgical design thus allowing cutting structures capable of drilling a variety of formations from IADC 11 to 41 and fixed cutter type applications with superior performance. This paper will: Explain the PF manufacturing process, highlighting lessons learned in the development learning curve. Review the benefits of producing bits using this process. Examine actual field results showing the cost savings available through application of cutting edge technologies. Discuss the improved wear characteristics of PF bits that has led to changes in operational variables such as weight on bit, rpm, hydraulic horsepower and monitoring drilling progress based on changes in rate of penetration.
El uso de la Bicicleta como medio de Transporte en el área metropolitana (2018)

En la actualidad, la bicicleta es considerada cada vez mas como un medio de transporte real, en el area metropolitana se evidencia que ya no es solo considerada como una opcion para hacer ejercicio o utilizada para actividades recreativas, es una tendencia que cada vez va creciendo por los grandes beneficios que aporta a la comunidad en general al momento de ahorrar tiempo y dinero en mantenimiento a comparacion de los medios de transporte tradicionales. El objetivo principal de este trabajo es demostrar que la bicicleta es un medio de transporte tambien utilizado por aquellas personas que trabajan y que han optado por esta opcion para llegar a sus lugares de labores cotidianas, mejorando asi su calidad de vida, estado fisico y psicologico; como sabemos el mantenimiento de este medio no es costoso y hace menos tedioso el transporte por las ciudades a la hora de ir al trabajo y ademas es muy bueno para la salud.
Ent cytotoxic system of normal serum. Abstr. (1960)

The dedicated contouring tool allows greater precision and reduction of inter-observer differences in the delineation of the target in SBRT spines. Thus, the evaluated system could be useful in the setting of spinal SBRT to reduce uncertainties of contouring increasing the level of precision on target delivered doses.
Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region (2008)

The interplay between dopamine and alpha-synuclein (AS) plays a central role in Parkinson's disease (PD). PD results primarily from a severe and selective devastation of dopaminergic neurons in substantia nigra pars compacta. The neuropathological hallmark of the disease is the presence of intraneuronal proteinaceous inclusions known as Lewy bodies within the surviving neurons, enriched in filamentous AS. In vitro, dopamine inhibits AS fibril formation, but the molecular determinants of this inhibition remain obscure. Here we use molecular dynamic (MD) simulations to investigate the binding of dopamine and several of its derivatives onto conformers representative of an NMR ensemble of AS structures in aqueous solution. Within the limitations inherent to MD simulations of unstructured proteins, our calculations suggest that the ligands bind to the (125)YEMPS(129) region, consistent with experimental findings. The ligands are further stabilized by long-range electrostatic interactions with glutamate 83 (E83) in the NAC region. These results suggest that by forming these interactions with AS, dopamine may affect AS aggregation and fibrillization properties. To test this hypothesis, we investigated in vitro the effects of dopamine on the aggregation of mutants designed to alter or abolish these interactions. We found that point mutations in the (125)YEMPS(129) region do not affect AS aggregation, which is consistent with the fact that dopamine interacts non-specifically with this region. In contrast, and consistent with our modeling studies, the replacement of glutamate by alanine at position 83 (E83A) abolishes the ability of dopamine to inhibit AS fibrillization.
In Vitro Selection and Characterization of <i>Bacillus anthracis</i> Mutants with High-Level Resistance to Ciprofloxacin (2003)

ABSTRACT Mutants of attenuated Bacillus anthracis with high-level ciprofloxacin resistance were isolated using a three-step in vitro selection. Ciprofloxacin MICs were 0.5 μg/ml for first-step mutants, which had one of two gyrA quinolone resistance-determining region (QRDR) mutations. Ciprofloxacin MICs were 8 and 16 μg/ml for second-step mutants, which had one of three parC QRDR mutations. Ciprofloxacin MICs for third-step mutants were 32 and 64 μg/ml. Mutants for which MICs were 64 μg/ml had one of two additional mutations within the gyrA QRDR or one of two mutations within the gyrB QRDR. Mutants for which MICs were 32 μg/ml had no additional target modifications but showed evidence of enhanced ciprofloxacin efflux.
Simple method for examining sulphur passivation of facets in InGaAs–AlGaAs (λ=0.98 μm) laser diodes (1996)

The effect of (NH4)2Sx treatment of the facet of InGaAs/AlGaAs ridge waveguide (RW) laser diodes on the nonradiative current and catastrophic optical damage (COD) level is reported. Using the power–voltage–current (P–V–I) characteristics of the electroluminescence at low injection levels, changes in the density of surface states at the laser facets are described.
A halothane challenge test to detect turkeys prone to developing pale, soft, and exudative meat (1998)

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item.
Data fusion and collaborative state estimation in wireless sensor networks (2015)

The aim of the thesis is to develop fusion algorithms for data collected from a wireless sensor network in order to locate multiple sources emitting some chemical or biological agent in the air. These sensors detect the concentration of the emitted substance, transported by advection and diffusion, at their positions and communicate this information to a treatment center. The information collected in a collaborative manner is used first to locate the randomly deployed sensors and second to locate the sources. Applications include, amongst others, environmental monitoring and surveillance of sensitive sites as well as security applications in the case of an accidental or intentional release of a toxic agent. However, the application we consider in the thesis is that of landmine detection and localization. In this approach, the land mines are considered as sources emitting explosive chemicals. The thesis includes a theoretical contribution where we extend the Belief Propagation algorithm, a well-known data fusion algorithm that is widely used for collaborative state estimation in sensor networks, to the bounded error framework. The novel algorithm is tested on the self-localization problem in static sensor networks as well as the application of tracking a mobile object using a network of range sensors. Other contributions include the use of a Bayesian probabilistic approach along with data analysis techniques to locate an unknown number of vapor emitting sources.
Effects of <i>L</i>-Threo-3,4-Dihydroxyphenylserine on Orthostatic Hypotension in Hemodialysis Patients (2002)

These results indicate that L-DOPS is effective for improving OH-related interdialytic subjective symptoms in HD patients after short-term as well as after long-term administration.
Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032) (2012)

Asunaprevir (ASV; BMS-650032) is a hepatitis C virus (HCV) NS3 protease inhibitor that has demonstrated efficacy in patients chronically infected with HCV genotype 1 when combined with alfa interferon and/or the NS5A replication complex inhibitor daclatasvir. ASV competitively binds to the NS3/4A protease complex, with K(i) values of 0.4 and 0.24 nM against recombinant enzymes representing genotypes 1a (H77) and 1b (J4L6S), respectively. Selectivity was demonstrated by the absence of any significant activity against the closely related GB virus-B NS3 protease and a panel of human serine or cysteine proteases. In cell culture, ASV inhibited replication of HCV replicons representing genotypes 1 and 4, with 50% effective concentrations (EC(50)s) ranging from 1 to 4 nM, and had weaker activity against genotypes 2 and 3 (EC(50), 67 to 1,162 nM). Selectivity was again demonstrated by the absence of activity (EC(50), >12 μM) against a panel of other RNA viruses. ASV exhibited additive or synergistic activity in combination studies with alfa interferon, ribavirin, and/or inhibitors specifically targeting NS5A or NS5B. Plasma and tissue exposures in vivo in several animal species indicated that ASV displayed a hepatotropic disposition (liver-to-plasma ratios ranging from 40- to 359-fold across species). Twenty-four hours postdose, liver exposures across all species tested were ≥110-fold above the inhibitor EC(50)s observed with HCV genotype-1 replicons. Based on these virologic and exposure properties, ASV holds promise for future utility in a combination with other anti-HCV agents in the treatment of HCV-infected patients.
A portable TPM based on USB key (2010)

Trusted computing technology aims to enhance the security of platform by the TPM. But there are some drawbacks of TCG's Trusted Computing architecture for user-based applications. This paper presents a new concept of portable TPM (PTM) based on USB Key to solve those problems. At first, we use PTM to establish a trusted path between the verifier and the user in remote attestation so as to propagate the trust chain to the end user. Secondly, we design the trust model and platform management mechanism of PTM. In this model the single point failure of TPM and frequent sensitive data migrations between different platforms are avoided based on PTM. At last, we implement the PTM on the USB Key with Java Card Runtime Environment. The test results show that the PTM scheme is feasible for user-based application.
Photosensor Based on an FET Utilizing a Biocomponent of Photosystem I for Use in Imaging Devices (2009)

We have investigated a photosensor that consists of a field emission transistor (FET) utilizing the biocomponent of the photosystem I (PSI) protein complex for use in an imaging device. The PSI was immobilized on a gold electrode via the self-assembling monolayer (SAM) of 3-mercapto-1-propanesulfonic acid sodium salt to obtain a PSI-modified gold electrode. As for the PSI-modified gold electrode, the basic photoresponses originating from the excitation of PSI, including the photocurrent (106 nA) and the photoresponse of the open-circuit voltage (photo-Voc: 28.6 mV), were characterized. Then, the PSI-modified gold electrode was linked to the gate of the FET using a lead line, and the device was successfully driven by the photoelectric signals from the PSI like a voltage follower circuit. Further, we successfully demonstrated that the PSI-based FET acts as a photosensor in imaging devices.
The β-Adrenergic Blocking Agents Pharmacology and Structure-Activity Relationships (1966)

Outside chemical interference with the sympathetic nervous system through the administration of drugs has resulted in major advances in the therapy of respiratory, cardiovascular, and mental diseases. Agents capable of blocking or enhancing the action of epinephrine and norepinephrine, regulating their biosynthesis or metabolism, influencing their uptake or release from storage sites became valuable tools in the study of the etiology of many pathologic processes and in the elucidation of the various functions of these neurohormones.
DIRECT VISUALIZATION OF DORSAL NERVE ROOTS OF THE CAUDA EQUINA BY MEANS OF A MYELOSCOPE (1938)

An instrument has been devised permitting direct visualization of the nerve roots of the cauda equina by means of a small endoscope. The apparatus is sufficiently small to be inserted readily between any of the lumbar spinous processes, in the same manner as an ordinary lumbar puncture needle. Local procaine anesthesia is used for skin and subcutaneous tissues. A view of the arachnoid membrane, the underlying dorsal roots and their accompanying blood vessels may thus be obtained. In addition, it is usually possible to observe the flow of blood through the veins and arteries of the nerve roots. The instrument was first considered about two years ago, and a rather crude preliminary device, consisting of a cannula and suitable trochars, was constructed. With this instrument it was possible to enter the spinal canal of the cadaver and visualize the lumbosacral nerve roots and their vessels. Observation and illumination were achieved
??-BSM??: A Biomimetic Bone Substitute and Drug Delivery Vehicle (1999)

α-BSM® is a biomimetic endothermically setting apatitic calcium phosphate bone substitute material. Its injectability and ability to harden at body temperature in the presence of physiologic saline, and other buffering agents, makes it an attractive clinical bone substitute and delivery vehicle for therapeutic agents in orthopaedic and dental applications. In osseous tissue, α-BSM® alone remodels into bone and promotes bone healing. α-BSM® treatment has been shown in several animal models to be effective in promoting healing of surgically created critical size defects and restoring bone biomechanical strength to values equal to or greater than values achieved with autograft controls. In vitro studies with α-BSM® containing gentamicin show that antibiotics can be incorporated stably into α-BSM® and that the release kinetics can be controlled with the appropriate formulation and preparative procedures. Growth factors and enzymes also are compatible with the α-BSM® setting reaction. The incorporation of recombinant human bone morphogenetic protein-2 with α-BSM® was shown to be effective in stimulating bone formation and accelerating restoration of the differentiated phenotype in an osteotomy model. Clinical trial investigators in Europe currently are using α-BSM® implantations for treatment of fractures and other indications.
Two-layered construction of integrated optical circuits and formation of thin-film prisms, lenses, and reflectors (1974)

We have demonstrated a new form of a two-layered construction of optical circuits. In this method, thin-film optical devices are covered by a single continuous layer of light-guiding film which serves as the interconnections as well as the input and output terminals. We also have demonstrated the construction of thin-film prisms, lenses, and a novel corner reflector in this type of structure.
Threonine Locus of <i>Escherichia coli</i> K-12: Genetic Structure and Evidence for an Operon (1974)

Three genes, thrA, thrB, and thrC, were previously defined and localized in the threonine locus of Escherichia coli K-12. thrA, thrB, and thrC specify the enzymes aspartokinase I-homoserine dehydrogenase I, homoserine kinase, and threonine synthetase, respectively. A complementation analysis of the threonine cluster using derivatives of a lambda phage carrying the threonine genes (lambdadthr(c)) demonstrates that: (i) thrB and thrC each consist of a single cistron; and (ii) thrA is composed of two cistrons, thrA(1) and thrA(2), although it specifies a single polypeptide chain. thrA(1) and thrA(2) correspond to aspartokinase I and homoserine dehydrogenase I, respectively. Their relative order is established. The demonstration of polar effects of mutations (nonsense or induced by phage Mu) in thrA and thrB is taken as evidence for the existence of a thrA thrB thrC operon, transcribed in this order.
Personalized Health Care and Health Information Technology Policy: An Exploratory Analysis (2013)

Personalized healthcare (PHC) is envisioned to enhance clinical practice decision-making using new genome-driven knowledge that tailors diagnosis, treatment, and prevention to the individual patient. In 2012, we conducted a focused environmental scan and informal interviews with fifteen experts to anticipate how PHC might impact health Information Technology (IT) policy in the United States. Findings indicatedthat PHC has a variable impact on current clinical practice, creates complex questions for providers, patients, and policy-makers, and will require a robust health IT infrastructure with advanced data architecture, clinical decision support, provider workflow tools, and re-use of clinical data for research. A number of health IT challenge areas were identified, along with five policy areas including: interoperable clinical decision support, standards for patient values and preferences, patient engagement, data transparency, and robust privacy and security.
One Tesla rare-earth permanent quadrupole magnet for spin separation of metal clusters (1987)

We have constructed a 1.20-T pole tip field quadrupole magnet which is used to separate electrically neutral metal clusters by their spin magnetic moment. The device is magnetically energized with rare-earth samarium cobalt magnets. The use of this material allows for both the low cost and the small size of the device.
The safety and efficacy of different dose schedules of hyaluronic acid in the treatment of painful osteoarthritis of the knee with joint effusion (1995)

Intra-articularly administered hyaluronic acid (HA) has been shown to be effective, in the treatment of knee osteoarthritis (OA). We carried out a double-blind randomised placebo- and arthrocentesis-controlled study to evaluate the efficacy of 3 different dose schedules of HA. One hundred patients with knee OA and at least 3cc of joint effusion were enrolled and randomly assigned to the 5 treatment groups. Pain on movement and at rest, the Lequesne index, joint mobility, volume of joint effusion, intake of analgesic, and overall judment of efficacy were evaluated at baseline and on Days 7, 14, 21, 28, 35, and 60. Recurrence was also evaluated up to six months. The evaluation of these parameters showed a signiicently superior effect of 5 and 3 injections of HA in comparison with placebo, arthrocentesis and one injection of HA. Long-term monitoring of the patients, over a period of six months, provided evidence of the value of repeater injections of HA in terms of maintenance of the results. Only few local adverse reactions, essentially transitory pain after injection, were reported. These reactions were equally distributed between the groups
Significance of the N‐6/N‐3 Ratio for Insulin Action in Diabetes (1993)

This report supplies supportive data for the hypothesis that a high n-6/n-3 dietary fat ratio is a potent, negative variable in NIDDM. Further work is necessary to critically evaluate this hypothesis.
Holophonic Sound in IRCAM's Concert Hall: Technological and Aesthetic Practices (2016)

This article presents a report on technological and aesthetic practices in the variable-acoustics performance hall, Espace de Projection, at the Institut de Recherche et Coordination Acoustique/Musique. The hall is surrounded by a 350-loudspeaker array for sound-field reproduction using holophonic approaches such as wave-field synthesis and higher-order Ambisonics. First we present the design and implementation of the audio system and discuss the challenges of both hardware and software architectures. This is followed by a discussion of spatial composition techniques, aesthetic approaches, and methodologies for composing computer music for high-density loudspeaker arrays, explored through the paradigmatic examples of pieces produced by two artist-in-research residencies.
Measurement of Floc Strength by Particle Counting (1967)

The objective of a conventional treatment plant is to produce floc of such size and density that the major portion will settle out in the allowed settling time, and the amount of remaining turbidity will be removed by the filter. Strength of the floc is one factor that affects the success with which suspended solids are removed from the water in the various unit operations. This paper reviews some of the factors that may affect floc strength, and describes a method for measuring the relative strength of floc formed under various conditions.
Spark Plug Voltage Analysis for Monitoring Combustion in an Internal Combustion Engine (1993)

<div class="htmlview paragraph">The idea to monitor the combustion in an internal combustion engine and using the obtained data to control combustion in the engine has been around for some time now. There are two well-known methods, although in the capacity of lab experiments, which had been developed under this principle. One features the analysis of combustion pressure and the other features the analysis of ionic currents detected in the combustion gas. Although highly precise analysis can be achieved by the former, there are problems in the installation of sensors for detecting combustion pressure, also in the durability and cost of such sensors. As for the latter, there are also problems in installing sensors for detecting the ionic currents and the reliability of obtained data from such sensors is still questionable. For these reasons, no internal combustion engine control systems have been practicalized that use these methods, i.e. for continuously monitoring all cylinders in an internal combustion engine of a car.</div> <div class="htmlview paragraph">The authors carried out research on a method which uses spark plug voltage analysis for monitoring the combustion in an internal combustion engine. By this method, the spark plug voltage becomes measured by voltage sensors, installed (non-contact) on the high voltage zone, in the vicinity of the spark plugs. The monitoring can be easily done in real time by processing the waveform data and measuring the density of ions. This method can be effectively used for continuous monitoring of all cylinders in the internal combustion engine. Such monitoring can also achieve controlling the combustion to be constantly maintained under optimal preset conditions, even when the combustion fluctuates due to effects by the air/fuel ratio, EGR, ignition timing, etc., be it for lean-burn engines or other conventional engines. By being able to control the driving condition to be within the lean limit, the EGR limit, and the retard limit, it has become possible to satisfy the three factors, fuel consumption, exhaust gas emission, and driveability, a feat considered difficult to achieve, in high dimensional terms.</div>
Agricultural Use of Burkholderia (Pseudomonas) cepacia: A Threat to Human Health? (1998)

In the past 2 decades, Burkholderia cepacia has emerged as a human pathogen causing numerous outbreaks, particularly among cystic fibrosis (CF) patients. One highly transmissible strain has spread across North America and Britain, and another between hospitalized CF and non-CF patients. Meanwhile, the organism has been developed as a biopesticide for protecting crops against fungal diseases and has potential as a bioremediation agent for breaking down recalcitrant herbicides and pesticides. However, B. cepacia is inherently resistant to multiple antibiotics; selection of strains "safe" for environmental application is not at present possible phenotypically or genotypically; molecular epidemiology and phylogenetic studies demonstrate that highly transmissible strains emerge randomly; and the organism has a capacity for rapid mutation and adaptation (facilitated by numerous insertion sequences), and a large, complex genome divided into separate chromosomes. Therefore, the widespread agricultural use of B. cepacia should be approached with caution.
Synthesis of the Furanosteroidal Antibiotic Viridin (2004)

A rhodium-catalyzed alkyne cyclotrimerization, domino electrocyclic reactions, and a hydroxy-directed dihydroxylation are key steps in an efficient synthesis of the bioactive furanosteroid viridin (1) from a simple acyclic triyne.