gebhart/patrepeval huggingface dataset:
Vascular and Cellular Targeting for Photodynamic Therapy (2006)

Photodynamic therapy (PDT) involves the combination of photosensitizers (PS) with light as a treatment, and has been an established medical practice for about 10 years. Current primary applications of PDT are age-related macular degeneration (AMD) and several types of cancer and precancer. Tumor vasculature and parenchyma cells are both potential targets of PDT damage. The preference of vascular versus cellular targeting is highly dependent upon the relative distribution of photosensitizers in each compartment, which is governed by the photosensitizer pharmacokinetic properties and can be effectively manipulated by the photosensitizer drug administration and light illumination interval (drug-light interval) during PDT treatment, or by the modification of photosensitizer molecular structure. PDT using shorter PS-light intervals mainly targets tumor vasculature by confining photosensitizer localization within blood vessels, whereas if the sensitizer has a reasonably long pharmacokinetic lifetime, then PDT at longer PS-light intervals can induce more tumor cellular damage, because the photosensitizer has then distributed into the tumor cellular compartment. This passive targeting mechanism is regulated by the innate photosensitizer physicochemical properties. In addition to the passive targeting approach, active targeting of various tumor endothelial and cellular markers has been studied extensively. The tumor cellular markers that have been explored for active photodynamic targeting are mainly tumor surface markers, including growth factor receptors, low-density lipoprotein (LDL) receptors, transferrin receptors, folic acid receptors, glucose transporters, integrin receptors, and insulin receptors. In addition to tumor surface proteins, nuclear receptors are targeted, as well. A limited number of studies have been performed to actively target tumor endothelial markers (ED-B domain of fibronectin, VEGF receptor-2, and neuropilin-1). Intracellular targeting is a challenge due to the difficulty in achieving sufficient penetration into the target cell, but significant progress has been made in this area. In this review, we summarize current studies of vascular and cellular targeting of PDT after more than 30 years of intensive efforts.
Effect of PEEP and Tidal Volume on Ventilation Distribution and End-Expiratory Lung Volume: A Prospective Experimental Animal and Pilot Clinical Study (2013)

Tidal recruitment and end-inspiratory overinflation can be assessed by EIT-based analysis of regional C(RS).
Mutational analysis of the simian immunodeficiency virus SIVmac nef gene (1991)

We are using site-directed mutagenesis of single viral genes to identify and analyze the genetic determinants of human and simian immunodeficiency virus pathogenicity. In a first approach, we have constructed a series of simian immunodeficiency virus SIVmac nef mutants by partial deletion and insertions in the nef gene, as this gene is a candidate gene for the establishment and maintenance of latency. nef insertion mutants replicated faster than wild-type SIVmac, suggesting that the nef gene product acts as a negative factor for replication. Surface phenotyping revealed that cultures permanently infected with nef mutants exhibit an enhanced expression of viral proteins on the outer cell surface. We have analyzed the properties of the mutant viruses in cell culture and intend to use rapidly replicating mutants (putatively unable to undergo latency) as model vaccine viruses in the rhesus monkey.
Developing novel anti-fibrotic therapeutics to modulate post-surgical wound healing in glaucoma: big potential for small molecules (2014)

Ocular fibrosis leads to significant visual impairment and blindness in millions of people worldwide, and is one of the largest areas of unmet need in clinical ophthalmology. The antimetabolites, mitomycin C and 5-fluorouracil, are the current gold standards used primarily to prevent fibrosis after glaucoma surgery, but have potentially blinding complications like tissue damage, breakdown and infection. This review thus focuses on the development of new classes of small molecule therapeutics to prevent post-surgical fibrosis in the eye, especially in the context of glaucoma filtration surgery. We discuss recent advances and innovations in ophthalmic wound healing research, including antibodies, RNAi, gene therapy, nanoparticles, liposomes, dendrimers, proteoglycans and small molecule inhibitors. We also review the challenges involved in terms of drug delivery, duration of action and potential toxicity of new anti-fibrotic agents in the eye.
A Review of Unquestioned Standards in Using Cluster Analysis for Data-Driven Market Segmentation (2002)

Clustering is a highly popular and widely used tool for identifying or constructing databased market segments. Over decades of applying cluster analytical procedures for the purpose of searching for homogeneous subgroups among consumers, questionable standards of utilization have emerged, e.g. the non-explorative manner in which results from cluster analytic procedures are reported, the black-box approach ignoring crucial parameters of the algorithms applied or the lack of harmonization of methodology chosen and data conditions. The purpose of this study is threefold: (1) to investigate whether and which standards of application of cluster analysis have emerged in the academic marketing literature, (2) to compare these standards of application to methodological knowledge about clustering procedures and (3) suggest changes in clustering habits. These goals are achieved by systematically reviewing 243 data-driven segmentation studies that apply cluster analysis for partitioning purposes.
Prolactin receptors on human T and B lymphocytes: antagonism of prolactin binding by cyclosporine. (1985)

Prolactin (PRL) receptors have been identified recently on human peripheral blood mononuclear cells (MNC) and may be involved in the regulation of cell-mediated immunity. Cyclosporine (CsA), an immunosuppressive cyclic endecapeptide utilized to prolong graft survival in human organ transplant patients, affects PRL binding to MNC. At concentrations of CsA from 10(-10) through 10(-8) M, the amount of PRL bound to MNC markedly increased to ca. 400% of controls, whereas CsA concentrations of 10(-6) and 10(-5) M totally inhibited PRL binding to lymphocytes. The ability of low concentrations of CsA to enhance PRL binding was temperature-dependent and did not occur when binding assays were conducted at 4 degrees C. PRL displaced [3H]CsA from lymphocytes with ca. 50% displacement at 10(-9) M PRL and total displacement at concentrations of 10(-7), 10(-6), and 10(-5) M. Growth hormone did not displace [3H]CsA in similar experiments. CsA also did not alter the binding of a beta-receptor antagonist to MNC, again suggesting that CsA was specific in its antagonism of PRL binding. A CsA analog with no immunosuppressive action, cyclosporin H, did not alter PRL binding to MNC. Furthermore, PRL receptors were demonstrated on four cell lines of human and mouse origin. Finally, PRL receptors were identified on purified populations of T and B lymphocytes isolated from human spleens, and CsA again inhibited PRL binding at concentrations of 10(-7) and 10(-6) M. The presence of PRL receptors on T and B lymphocytes suggests that PRL may be involved in the regulation of humoral and cell-mediated immunity, and that one effect of CsA on immune function may be its ability to inhibit the effects of PRL action on these lymphocytes.
Calibration of test fixtures using at least two standards (microwave circuits) (1991)

The determination of the error networks in measurements of microwave circuits with arbitrary test fixtures is studied. A general-purpose deembedding method for known standards is shown. Also, a method for symmetrical test fixtures is described. The method uses only two fixture standards, of which one must be a two-port standard with a transmission not equal to zero. A computer simulation is used to compare the error sensitivities of the different calibration algorithms. The main advantage of the methods described is that the standards can be modeled freely and any idealization or restriction to certain special standards is not necessary. Any kind of standard can be used if the S-parameters are known or if a circuit model for the standard can be determined. Also, the dispersion of the microstrip line standards can easily be taken into account.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Low-noise 8 GHz PIN/FET optical receiver (1987)

An ultrawide-bandwidth, low-noise optical receiver has been designed for use in both multigigabit direct-detection or coherent heterodyne systems at 1.3 and 1.55 μm wavelengths. The receiver consists of a low-capacitance InGaAs PIN photodiode connected to a high-impedance three-stage GaAs FET preamplifier. Inductive peaking at the front end is used to reduce the receiver noise at high frequencies. The receiver has an equivalent input RMS noise current of < 12 pA/√Hz from 4 to 7 GHz. The measured 3 dB bandwidth of 8 GHz is the widest receiver bandwidth reported to date.
Successful treatment with DL-alpha-difluoromethylornithine in established human small cell variant lung carcinoma implants in athymic mice. (1983)

We report that p.o. administration of DL-alpha-difluoromethylornithine (DFMO), a specific inhibitor of polyamine biosynthesis, markedly inhibits the growth of established implants of cultured human small cell lung carcinoma (SCC) in athymic (nude) mice. Human SCC tumor cells, from a cell line which exhibited cell death in culture in the presence of DFMO, were inoculated s.c. into athymic mice. The tumors were permitted to grow until they became palpable (0.05 cu cm, 3- to 5-mm-diameter nodules). The animals were then randomized into control, and early (low tumor burden) and late (high tumor burden) treatment groups which received 3% DFMO in the drinking water (5.0 g/kg/day). The tumors in the untreated control group grew to a size of 29 cu cm by 9 weeks, and these animals had a median survival of 9 weeks. The late treatment group began DFMO treatment 3 weeks after clinical tumor engraftment, when mean tumor size was 1.5 cu cm (1.2- to 1.5-cm-diameter nodules). Tumor growth was inhibited by 60% (11.4 cu cm) by Week 9 and survival was prolonged, with 83% survival at 10 weeks and a 56% increase in median survival to 14 weeks (p less than 0.05). The early treatment group received the same dose of DFMO beginning 1 week after tumor engraftment, when their mean tumor size was 0.1 cu cm (4- to 6-mm-diameter nodules). The early DFMO group had a 99% inhibition in tumor growth (0.3 cu cm) (p less than 0.05). Survival was also prolonged compared to the untreated controls, with 83% survival at 10 weeks and a median survival of 15 weeks (p less than 0.05). In both the early- and late-DFMO-treatment groups, no significant clinical toxicities were observed in the first 10 weeks, during which antitumor therapeutic effects were seen. DFMO may have a potential role in the treatment of sensitive human tumors such as SCC. The data suggest that DFMO may be most useful clinically in patients with SCC who have a low tumor burden. Thus, DFMO might be an important tool to produce long-term maintenance of initial clinical remissions induced by combination chemotherapy.
Influences of gases on the field emission (1993)

Influences of gases on the field emission were measured using the specimens of Spindt-type Mo field emitter array. Gases were introduced into a vacuum chamber where the specimens were driven with pulse and dc voltages to emit electrons. In case of pulse drive, effects of N2 , H2 , Ar, or CO2 on emitter arrays could hardly be observed until the vacuum level reduced to 5×10−6 Torr. When the vacuum level was recovered to the background level, emission showed the recovery to be almost the same value as that before gas introduction. When pulse driven, a small amount of H2 gas reduced the work function of the emitter surface and increase the emission characteristics of emission array. In case of dc drive, on the other hand, emission began decreasing at 10−7 Torr. The introduction of SO2 led to the decrease of emission to ∼70% of the initial value at 5×10−6 Torr because of the contamination of emitter tips caused by SO2 when pulse driven. It was also clarified that CH4 , H2 , and CO adsorbed to emitters to reduce the work function of emitter tips. Particularly with CH4 , emission was doubled or more the initial value at 5×10−5 Torr.
Cardioactive C<sub>19</sub>-Diterpenoid Alkaloids from the Lateral Roots of <i>Aconitum carmichaeli</i> “Fu Zi” (2012)

Bioassay-guided fractionation of an n-BuOH extract of the lateral roots of Aconitum carmichaeli. led to the isolation of 5 cardioactive C(19)-diterpenoid alkaloids: N-deethylaconine (1), beiwutinine (2), hypaconine (3), mesaconine (4), and 15α-hydroxyneoline (5). N-Deethylaconine and beiwutinine are new aconitine-type C(19)-diterpenoid alkaloids. Hypaconine was isolated from this species for the first time. Among them, mesaconine, hypaconine, and beiwutinine showed the strongest cardiac actions on the isolated perfused bullfrog heart. Furthermore, mesaconine has protective effects, including improved inotropic effect and left ventricular diastolic function, on myocardial ischemia-reperfusion injury in rat at a dose of 10(-9) mol/L. However, mesaconine has almost no effect on heart rate.
Polyamides 4.10 and 4.12 and their Isomers (1999)

A series of aliphatic 1, 4-diaminobutane based polyamides 4. y with y = 8, 9, 10 and 12 was synthesized and characterized. For comparison, some 1, 6-diaminohexane based counterparts were also studied. PA 4.12, and in particular PA 4.10, proved to have a very beneficial combination of T m , crystallization rate and physical properties. First indications were obtained, that for a series of aliphatic polyamide isomers, containing 16 carbon atoms in the repeating unit, the melting points are related to the number of ways to make an energetically favourable chain fold upon crystallization: isomers having two possible ways of chain folding have T m s which are 13–15 °C lower than isomers having only one possible way of chain folding upon crystallization.
Plant signal molecules activate the syrB gene, which is required for syringomycin production by Pseudomonas syringae pv. syringae (1991)

The syrB gene is required for syringomycin production by Pseudomonas syringae pv. syringae and full virulence during plant pathogenesis. Strain B3AR132 containing a syrB::lacZ fusion was used to detect transcriptional activation of the syrB gene in syringomycin minimal medium by plant metabolites with signal activity. Among 34 plant phenolic compounds tested, arbutin, phenyl-beta-D-glucopyranoside, and salicin were shown to be strong inducers of syrB, giving rise to approximately 1,200 U of beta-galactosidase activity at 100 microM; esculin and helicin were moderate inducers, with about 250 to 400 U of beta-galactosidase activity at 100 microM. Acetosyringone and flavonoids that serve as signal molecules in Agrobacterium and Rhizobium species, respectively, did not induce the syrB::lacZ fusion. All syrB inducers were phenolic glucosides and none of the aglucone derivatives were active, suggesting that the beta-glycosidic linkage was necessary for signal activity. Phenyl-beta-D-galactopyranoside containing galactose substituted for glucose in the beta-glycosidic linkage also lacked inducer activity. Phenolic signal activity was enhanced two- to fivefold by specific sugars common to plant tissues, including D-fructose, D-mannose, and sucrose. The effect of sugars on syrB induction was most noticeable at low concentrations of phenolic glucoside (i.e., 1 to 10 microM), indicating that sugars such as D-fructose increase the sensitivity of P. syringae pv. syringae to the phenolic plant signal. Besides induction of syrB, syringomycin biosynthesis by parental strain B3A-R was induced to yield over 250 U of toxin by the additions of arbutin and D-fructose to syringomycin minimal medium. These data indicate that syringomycin production by most strains of P. syringae pv. syringae is modulated by the perception of two classes of plant signal molecules and transduced to the transcriptional apparatus of syringomycin (syr) genes such as syrB.
Sortase-Catalyzed Peptide−Glycosylphosphatidylinositol Analogue Ligation (2009)

It is demonstrated that sortase A (SrtA) can catalyze efficient coupling of peptides to GPI analogues with a glycine residue attached to the phosphoethanolamine moiety at the nonreducing end to form GPI-linked peptides. This represents the first chemoenzymatic synthesis of GPI-peptide conjugates and is a proof-of-concept for the potential application of SrtA to the synthesis of more complex GPI-anchored peptides/glycopeptides and GPI-anchored proteins/glycoproteins.
Performance comparison of small form factor fiber optic connectors (2000)

A comparison of small form factor (SFF) fiber optic connectors is presented for LC, MT-RJ, SC-DC, and VF-45. Multimode jumper cables were tested using industry standard test procedures and bench marked against the industry standard SC Duplex connector. Initial loss data as well as stress testing was performed. Variations were found in the performance of the connectors types and between connectors of the same type from different suppliers. In some cases the connectors out performed the SC Duplex on some tests but no connectors out performed the SC Duplex on all tests with the mechanical stress tests of axial and off-axial pull being the most difficult to exceed. These connectors are rapidly developing and are at different levels of maturity but none of them tested out to be a fully mature replacement for the SC Duplex connector yet.
Spectral transformations through canonical correlation analysis for speaker adptation in ASR (2005)

This paper describes a technique of spectral transformation for improved adaptation of a knowledge data base or reference templates to new speakers in automatic speech recognition (ASR). Based on a statistical analysis tool (Canonical correlation analysis) the proposed method permits to improve speaker independance in Large vocabulary ASR. Application to an isolated word recognizer improved a 70% correct score to 87%.
A kinetic study of the adiabatic polymerization of acrylamide (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA kinetic study of the adiabatic polymerization of acrylamideR. A. M. Thomson Cite this: J. Chem. Educ. 1986, 63, 4, 362Publication Date (Print):April 1, 1986Publication History Received3 August 2009Published online1 April 1986Published inissue 1 April 1986https://doi.org/10.1021/ed063p362Request reuse permissionsArticle Views166Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alertsclose Get e-Alerts
Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of America (2009)

Guidelines for the management of patients with invasive candidiasis and mucosal candidiasis were prepared by an Expert Panel of the Infectious Diseases Society of America. These updated guidelines replace the previous guidelines published in the 15 January 2004 issue of Clinical Infectious Diseases and are intended for use by health care providers who care for patients who either have or are at risk of these infections. Since 2004, several new antifungal agents have become available, and several new studies have been published relating to the treatment of candidemia, other forms of invasive candidiasis, and mucosal disease, including oropharyngeal and esophageal candidiasis. There are also recent prospective data on the prevention of invasive candidiasis in high-risk neonates and adults and on the empiric treatment of suspected invasive candidiasis in adults. This new information is incorporated into this revised document.
Color matching and illumination estimation for urban scenes (2009)

Photographs taken of the same scene often look very different, due to various conditions such as the time of day, the camera characteristics, and subsequent processing of the image. Prime examples are the countless photographs of urban centers taken throughout history. In this paper we present an approach to match the appearance between photographs that removes effects such as different camera settings, illumination, fading ink and paper discoloration over time, and digitization artifacts. Global histogram matching techniques are inadequate for appearance matching of complex scenes where background, light, and shadow can vary drastically, making correspondence a difficult problem. We alleviate this correspondence problem by registering photographs to 3D models of the scene. In addition, by estimating the calendar date and time of day, we can additionally remove the effect of drastic lighting and shadow differences between the photographs. We present results for the case of urban scenes, and show that our method allows for realistic visualizations by blending information from multiple photographs without color-matching artifacts.
Development of Transparent Ceramic Ce-Doped Gadolinium Garnet Gamma Spectrometers (2013)

Transparent polycrystalline ceramic scintillators based on the garnet structure and incorporating gadolinium for high stopping power are being developed for use in gamma spectrometers. Optimization of energy resolution for gamma spectroscopy involves refining the material composition for high stopping and high light yield, developing ceramics fabrication methodology for material homogeneity, as well as selecting the size and geometry of the scintillator to match the photodetector characteristics and readout electronics. We have demonstrated energy resolution of 4% at 662 keV for 0.05 cm <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$^{3}$</tex></formula> GYGAG(Ce) ceramics with photodiode readout, and 4.9% resolution at 662 keV for 18 cm <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$^{3}$</tex></formula> GYGAG(Ce) ceramics and PMT readout. Comparative gamma spectra acquired with GYGAG(Ce) and NaI(Tl) depict the higher resolution of GYGAG(Ce) for radioisotope identification applications. Light yield non-proportionality of garnets fabricated following different methods reveal that the fundamental shapes of the light yield dependence on energy are not intrinsic to the crystal structure, but may instead depend on trap state distributions. With exposure to 9 MeV Brehmsstrahlung radiation, we also find that GYGAG(Ce) ceramics exhibit excellent radiation hardness.