gebhart/patrepeval huggingface dataset:
A method for implementing dynamic, cloud-based metadata services based on a unified content ID space across a fragmented CE ecosystem (2012)

The number of digital entertainment sources has exploded. However, industry fragmentation makes it hard for consumers to discover and consume content across multiple devices from multiple entertainment service providers. A unified content ID space is one part of the solution. However, as seen from experience with the TV-Anytime CRID standard, unique URIs are not sufficient on their own to solve this problem. This paper sketches an extension to CRID that relies on real-time webservice protocols to dynamically resolve CRIDs across multiple, overlapping content sources (e.g. live TV, DVR, over-the-top content, DLNA servers, etc.). This proposal extends the usefulness of CRIDs outside the PVR use-case and addresses the messiness of the real-world where the same piece of content can be available from many different sources based on license restrictions, device capability and connectivity requirements. The paper also describes how layering dynamic metadata webservices onto the ID space can overcome the traditional problems faced in adopting industry-wide schemas for metadata.
Rapid Inhibition of Cancer Cell Growth Induced by Lentiviral Delivery and Expression of Mutant-Template Telomerase RNA and Anti-telomerase Short-Interfering RNA (2004)

In human cancers, telomeres are commonly maintained by elevated levels of the ribonucleoprotein enzyme telomerase, which contains an intrinsic templating RNA moiety (human telomerase RNA; hTER) and the core protein (human telomerase reverse transcriptase). We developed a lentiviral system for efficient overexpression of mutant-template human telomerase RNA (MT-hTer) to add mutant DNA to telomeres in cancer cells. We show that such MT-hTer overexpression rapidly inhibits cell growth and induces apoptosis in telomerase-positive precancerous or cancer cells but not in telomerase-negative cells. These rapid effects occurred independent of wild-type p53 and telomere length. Tumor growth and progression were significantly decreased in xenografts of human tumor cells overexpressing MT-hTers. Expression of a hairpin short-interfering RNA that specifically targeted the endogenous wild-type hTER template region, but spared the MT-hTers, also caused p53-independent cell growth inhibition and apoptosis, and when coexpressed with MT-hTer, synergistically killed cancer cells. Hence, anti-wild-type-hTER short-interfering RNA and MT-hTers may act through distinct pathways and, particularly in combination, represent a promising approach to anticancer therapies.
Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14. (2002)

We propose that (i) LTA from S. aureus triggers the release of cytokines during staphylococcal infections, and (ii) both monocytes and T cells contribute to cytokine production induced by LTA. TLR2 may mediate cellular activation by LTA, but the functional significance of this receptor during staphylococcal infections remains elusive.
Serum and synovial fluid levels of serum amyloid A protein and C-reactive protein in inflammatory and noninflammatory arthritis. (1988)

Serum and synovial fluid (SF) levels of serum amyloid A (SAA) and C-reactive protein (CRP) were measured in 46 cases of various inflammatory arthritis (Group 1), and in 40 cases of noninflammatory arthritis: 18 cases of osteoarthritis (Group 2) and 22 cases of traumatic arthritis (Group 3). Serum and SF SAA levels were markedly elevated in Group 1: 126.4 micrograms/ml +/- 19.2 SEM and 46.4 micrograms/ml +/- 10.5 SEM, respectively; moderately elevated in Group 2: 10.1 micrograms/ml +/- 2.9 SEM, 4.0 micrograms/ml +/- 1.1 SEM and moderately elevated in Group 3: 10.4 micrograms/ml +/- 1.2 SEM, 4.0 micrograms/ml +/- 1.2 SEM, respectively. Serum/SF SAA ratios were similar in all 3 groups and ranged between 2.52-2.72. In comparison to SAA, the increment of serum and SF CRP above normal levels was moderate. A positive strong correlation was found between serum SAA and serum CRP: r = 0.64 (p less than 0.001) and between SF SAA and SF CRP: r = 0.59 (p less than 0.0001). SF SAA did not correlate with the number of SF white blood cells but did correlate with the percent of SF polymorphonuclear cells: r = 0.23 (p less than 0.05).
Protection against bleomycin-induced lung injury by IL-18 in mice (2005)

The role of interleukin (IL)-18 in the protection from interstitial pneumonia and pulmonary fibrosis induced by bleomycin (BLM) was investigated by comparing the severity of BLM-induced lung injuries between wild-type and C57BL/6 mice with a targeted knockout mutation of the IL-18 gene (IL-18-/- mice). IL-18-/- mice showed much worse lung injuries than wild-type mice, as assessed by the survival rate, histological images, and leukocyte infiltration in the bronchoalveolar lavage fluid and myeloperoxidase activity. In wild-type mice, administration of IL-18 before BLM instillation resulted in suppression of lung injuries, increases in the hydroxyproline content, and decreases in the granulocyte-macrophage colony-stimulating factor content in the lung. Preadministration of IL-18 also resulted in prevention of the reduction of the lung IL-10 content caused by BLM-induced damage of alveolar epithelial. BLM instillation suppressed superoxide dismutase (SOD) activity in IL-18-/- mice to a greater extent than in wild-type mice. Pretreatment of IL-18 augmented Mn-containing superoxide dismutase (Mn-SOD) messenger RNA expression and SOD activity in the lung and prevented the reduction of SOD activity caused by BLM in both wild-type and IL-18-/- mice. These results suggest that IL-18 plays a protective role against BLM-induced lung injuries by upregulating a defensive molecule, Mn-SOD.
A thermoelectric voltage effect in polyethylene oxide (2003)

The conductivity of polyethylene oxide (PEO) is described with a three-dimensional hopping model considering electrostatic interactions between the ions. Ions fluctuate over energy-barriers in a multi-well potential. To decide whether positive or negative charges are responsible for this conductivity, the thermoelectric voltage is measured. The samples are embedded between two aluminium-electrodes. The oxide on the interface between the electrodes and the PEO serves as a blocking layer. The temperature of each electrode is controlled by a Peltier element. A temperature step is applied to one electrode by changing the temperature of one of the Peltier elements. Due to this temperature gradient, the mobile charges fluctuate thermally activated from the warmer side to the colder side of the sample. The direction of the measured thermoelectric voltage indicates the type of mobile charges. It is found that positive charges are mobile. Further, it is shown that the absolute value of the thermoelectric voltage depends on the energy-barrier heights in the multi-well potential.
Theory and experiment of magnetic bearing combining radial control and thrust control (1987)

A magnetic bearing system combining radial control and thrust control is discussed. The structure proposed in this paper is useful for the simplification of the five axes controlled magnetic bearing. It is, however, more difficult to design the suspension control system. At first, the modeling of the controlled system is made in the form of the state equation. Then, an integral type control system is designed based on the modern control theory, in which the optimization method for a Linear-Quadratic performance index or the In-the-Region Pole Allocation method are used. An experimental machine is produced, the electronic control system is set up, and several experiments are made successfully.
Building Data Warehouses Using The Enterprise Modeling Framework (2004)

This paper proposes an enterprise modeling framework for the deployment of data warehouses. The framework provides the information roadmap coordinating source data and different data warehouses across the business enterprise. The paper introduces a solution to address data warehousing issues at the enterprise level while avoiding the pitfalls of creating enterprise data warehouses and universal data marts. It further proposes a change of paradigm from point solutions focus to a methodology driven by enterprise requirements to meet the challenges of the new economy. The proposed framework emphasizes the separation of the conceptual construct from the physical and operational constructs of an enterprise. It points out the differences and dependencies of analytic and operational processes and how data warehouses and operational data stores respectively support their information requirements. This paper will demonstrate how the enterprise modeling framework for data warehousing can produce business benefits.
Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living (1969)

Journal Article Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living Get access M. Powell Lawton, PhD, M. Powell Lawton, PhD 2Research Psychologist Philadelphia Geriatric Center 5301 Old York RoadPhiladelphia 19141 Search for other works by this author on: Oxford Academic PubMed Google Scholar Elaine M. Brody, ACSW Elaine M. Brody, ACSW Director 3Department of Social WorkPhiladelphia Geriatric Center Search for other works by this author on: Oxford Academic PubMed Google Scholar The Gerontologist, Volume 9, Issue 3_Part_1, Autumn 1969, Pages 179–186, https://doi.org/10.1093/geront/9.3_Part_1.179 Published: 01 October 1969
Synthesis of nitroxides for use as procationic labels and their incorporation into nafion films (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of nitroxides for use as procationic labels and their incorporation into nafion filmsChantal Degrand, Benoit Limoges, and Ronald L. BlankespoorCite this: J. Org. Chem. 1993, 58, 9, 2573–2577Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/jo00061a037https://doi.org/10.1021/jo00061a037research-articleACS PublicationsRequest reuse permissionsArticle Views241Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-α treatment (2012)

COMP-C3b levels are elevated in several rheumatologic diseases and correlate with inflammatory measures in RA. COMP-C3b levels in RA decrease during TNF-α inhibition differently from those of CRP, suggesting that formation of COMP-C3b relates to disease features not reflected by general inflammation measures.
Nuclear Abundances in Metallic Hydride Electrodes of Electrolytic Chemical Cells (2006)

Low energy nuclear transmutations have been reported in experimental chemical electrolytic cells employing metallic hydride electrodes. Assuming that the nuclear transmutations are induced by ultra-low momentum neutron absorption, the expected chemical cell nuclear abundances are discussed on the basis of a neutron optical potential model. The theoretical results are in satisfactory agreement with available experimental chemical cell data. Some implications of these laboratory nuclear transmutations for r- s-process models of the neutron induced solar system and galactic nuclear abundance are briefly explored.
Isolation and Use of a Homologous Histone H4 Promoter and a Ribosomal DNA Region in a Transformation Vector for the Oil-Producing Fungus<i>Mortierella alpina</i> (2000)

Mortierella alpina was transformed successfully to hygromycin B resistance by using a homologous histone H4 promoter to drive gene expression and a homologous ribosomal DNA region to promote chromosomal integration. This is the first description of transformation in this commercially important oleaginous organism. Two pairs of histone H3 and H4 genes were isolated from this fungus. Each pair consisted of one histone H3 gene and one histone H4 gene, transcribed divergently from an intergenic promoter region. The pairs of encoded histone H3 or H4 proteins were identical in amino acid sequence. At the DNA level, each histone H3 or H4 open reading frame showed 97 to 99% identity to its counterpart but the noncoding regions had little sequence identity. Unlike the histone genes from other filamentous fungi, all four M. alpina genes lacked introns. During normal vegetative growth, transcripts from the two histone H4 genes were produced at approximately the same level, indicating that either histone H4 promoter could be used in transformation vectors. The generation of stable, hygromycin B-resistant transformants required the incorporation of a homologous ribosomal DNA region into the transformation vector to promote chromosomal integration.
Human natural killer cells isolated from peripheral blood do not rearrange T cell antigen receptor beta chain genes. (1986)

The lineage of NK cells and their relationship to T lymphocytes have been controversial issues. Since rearrangement of the T cell antigen receptor beta chain genes occurs early in the ontogeny and differentiation of all T cells, this can be used as an unequivocal marker to discriminate T from non-T lymphocytes. Recent studies (16-18) examining T cell antigen receptor gene rearrangement and expression in certain IL-2-dependent NK cell lines and leukemias have revealed that some lines rearrange C beta genes, whereas others do not. However, it is important to establish whether these cell lines are representative of the major population of NK cells freshly derived from the host. Herein, we have purified granulocytes, CD16+ NK cells and T lymphocytes from human peripheral blood, prepared genomic DNA from each cell type, and then examined the organization of their T cell antigen receptor genes by restriction enzyme analysis using a C beta cDNA as probe. The C beta genes were in germline configuration in NK cells and granulocytes. In contrast, peripheral blood T lymphocytes showed rearrangement of the C beta gene. These data support the hypothesis that the majority of human peripheral blood NK cells are fundamentally distinct from T lymphocytes in lineage and nonself recognition.
The Germicidal Properties of Soap (1925)

Journal Article The Germicidal Properties of Soap Get access John E. Walker John E. Walker From the Laboratory Service, Army and Navy General Hospital, Hot Springs, Ark. Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 37, Issue 2, August 1925, Pages 181–192, https://doi.org/10.1093/infdis/37.2.181 Published: 01 August 1925 Article history Received: 07 March 1925 Published: 01 August 1925
In Vivo Tracking of Stem Cells for Clinical Trials in Cardiovascular Disease (2004)

Various stem cells hold promise for the treatment of human cardiovascular disease. Regardless of stem cell origin, future clinical trials will require that the location and number of such cells be tracked in vivo, over long periods of time. The problem of tracking small numbers of cells in the body is a difficult one, and an optimal solution does not yet exist. We review the many contrast agents and detectors that have been proposed for stem cell tracking during clinical trials, define the characteristics of an ideal imaging technology, and suggest future directions for research.
A 6b 3GS/s flash ADC with background calibration (2009)

A 6b 3GS/s flash ADC is implemented in a 90 nm CMOS process. The proposed ADC is based on an interpolating flash architecture without a T/H. To overcome the offset mismatch among comparators, an interleaved offset-calibration system is applied. Each 1-bit interpolating unit consisting of two preamplifiers and three comparators takes turns at offset calibration in the background. The ADC achieves the ENOB of 5.8 bit at 3GS/s and the ERBW of 500 MHz while consuming 90 mW from a 1.2 V supply. The ADC occupies a 0.28 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> area.
Conformational entropy of alanine versus glycine in protein denatured states (2007)

The presence of a solvent-exposed alanine residue stabilizes a helix by 0.4-2 kcal.mol(-1) relative to glycine. Various factors have been suggested to account for the differences in helical propensity, from the higher conformational freedom of glycine sequences in the unfolded state to hydrophobic and van der Waals' stabilization of the alanine side chain in the helical state. We have performed all-atom molecular dynamics simulations with explicit solvent and exhaustive sampling of model peptides to address the backbone conformational entropy difference between Ala and Gly in the denatured state. The mutation of Ala to Gly leads to an increase in conformational entropy equivalent to approximately 0.4 kcal.mol(-1) in a fully flexible denatured, that is, unfolded, state. But, this energy is closely counterbalanced by the (measured) difference in free energy of transfer of the glycine and alanine side chains from the vapor phase to water so that the unfolded alanine- and glycine-containing peptides are approximately isoenergetic. The helix-stabilizing propensity of Ala relative to Gly thus mainly results from more favorable interactions of Ala in the folded helical structure. The small difference in energetics in the denatured states means that the Phi-values derived from Ala --> Gly scanning of helices are a very good measure of the extent of formation of structure in proteins with little residual structure in the denatured state.
Infectivity of<i>Chlamydia trachomatis</i>Serovar LGV but Not E Is Dependent on Host Cell Heparan Sulfate (2001)

The ability of heparan sulfate, heparin, and other glycosaminoglycans to inhibit the infectivity of Chlamydia trachomatis serovars E and LGV was examined using a simple competitive inhibition assay with three cell types from the human female reproductive tract, including primary human endosalpingeal cells. With the majority of the glycosaminoglycans tested, LGV was more significantly inhibited than serovar E. We have compared chlamydial infectivity between a wild-type Chinese hamster ovary cell line and two glycosaminoglycan-deficient cell lines. LGV was shown to be unable to infect heparan sulfate-deficient and GAG-deficient Chinese hamster ovary cell lines, whereas the E serovar infected these cells as efficiently as the control (nondeficient) cells. These two sets of experiments confirmed that serovar LGV is more dependent on a heparan sulfate-related mechanism of infectivity than is serovar E. This is further supported by the fact that attempts to purify a heparan sulfate-like molecule from either serovar cultured in glycosaminoglycan-deficient cell lines were nonproductive. Previous reports have suggested that chlamydia are able to produce a heparan sulfate-like molecule that is important for attachment and infectivity. We have attempted to detect possible binding of a specific heparan sulfate antibody to C. trachomatis by flow cytometry. Results showed no binding of the heparan sulfate antibody to C. trachomatis serovar LGV or E. Our results strongly indicate that chlamydiae do not produce a heparan sulfate-like molecule but rather use host cell heparan sulfate in order to infect cells.
Current Status and Emerging Trends in Wide Bandgap (WBG) Semiconductor Power Switching Devices (2013)

The current state-of-the-art of wide bandgap (WBG) semiconductor material technology is reviewed for the manufacturing of high-performance and reliable power electronics switching devices. In particular, silicon carbide (SiC) and gallium nitride (GaN) material and device technologies are evaluated when compared to conventional silicon power switching devices. For commercial applications above 400 volts, SiC stands out as a viable near-term commercial opportunity especially for single-chip current ratings in excess of 20 amps. For voltage ratings below 900 volts and smaller currents (below 20 amps), lateral GaN power transistors that utilize two-dimensional electron gas (2DEG) are promising candidates. At the time of this writing, field-reliability of WBG power devices is yet to be demonstrated in power converter applications. The exact role of high-density of material defects in both SiC and GaN semiconductors, primarily in the drift-region of the device, is not known from manufacturing and reliability considerations. This fundamental understanding is critical in order for WBG power devices to rapidly penetrate the vast commercial and strategic markets.
Age-specific associations between emotional responses to separation and cognitive performance in infancy. (1997)

Associations between emotional responses to maternal separation and cognitive performance were expected to change with cognitive development over the first year. In this longitudinal study of 39 infants, measures of separation and reunion distress at 2, 6, and 10 months were interleaved with measures of sensorimotor coordination at 4, 8, and 13 months. Separation distress at 2 months predicted lower sensorimotor scores, whereas separation distress at 6 and 10 months corresponded with higher scores. Duration of distress in reunion showed the same pattern of associations, when controlled for general emotionality Infants' positive engagement and physical touch with their mothers at 10 months predicted higher sensorimotor scores as well. Emotional responses and cognitive performance may be linked by individual differences in self-regulation and attentional engagement, as mediated by age-specific developmental issues.
Treatment of Swine Wastewater By Biological and Membrane Separation Technologies (2002)

A lab-scale integrated biological treatment and membrane separation system was studied for treatment of swinewastewater to achieve energy recovery, fertilizer production, and water reclamation. The system consisted ofone Anaerobic sequencing batch reactor (ASBR), two aerobic sequencing batch reactors (SBR1 and SBR2),one sludge settling tank, one sand filter and one reverse osmosis (RO) membrane separation unit. The systemwas tested with swine manure of 1.5% VS. After treatment with the ASBR and SBRs, COD, TS, VS, SS andVSS in the liquid effluent were reduced by 91.7%, 88.6%, 93.0%, 96.4%, and 97.1%, respectively, and therewas close to 3-log reduction in total coliforms and E coli. The ammonia in the liquid was partially oxidized intonitrite and nitrate. The sand filter further reduced COD and suspended solids in the liquid prior to ROtreatment. Two types of spiral wound RO membranes were tested and compared. The membrane separationresults showed that when the volume of concentrate reached 50% and 10% of original feed volume, theconcentrate contained about 90% and 70% of original total nitrogen, respectively, in the liquid effluent thatpassed through the sand filter. The reclamed water had very good quality.