gebhart/patrepeval huggingface dataset:
Design of Dynamically Wind-Loaded Helical Piers for Small Wind Turbines (2010)

The expansion of alternative energy has created a demand for sustainable alternatives for wind turbine foundation design. This study investigates the proposed application of helical piers as foundations for guyed cables of small (1–10-kW) wind towers. Before the foundation system can be implemented, pier response to typical working loads and extreme environmental conditions must be determined. Field conditions were determined by equipping an existing wind tower with accelerometers and load cells while monitoring wind speed to determine tower response. A full-scale testing program was conducted, which simulated dynamic loading conditions based on the tower response. The testing program varied between typical working conditions and extreme load events to determine the critical loading case and creep potential from long-term loading. This paper discusses the effects of dynamic loading on helical pier performance and compares the results to that of uplift prediction methods typically used in helical pier design.
Toll-Like Receptor 8-Mediated Reversal of CD4 <sup>+</sup> Regulatory T Cell Function (2005)

CD4+ regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these cells are regulated. We describe a mechanism linking Toll-like receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function. This effect was independent of dendritic cells but required functional TLR8-MyD88-IRAK4 signaling in Treg cells. Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced anti-tumor immunity. These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases.
The Distributed Mobile Cloud Supporting the Internet of Things (2015)

The Internet of Things (IoT) aims at connecting all communicating "things" that surround us. The acts of addressing billions of heterogeneous devices, interconnecting them and running cost-effective applications on top of them require new architectures, services and protocols. This position paper presents our thoughts on IoT and discusses a distributed cloud model for supporting IoT and its applications.
Investigations Of Iron Adducts Of C-60 - Novel Fec60 In The Solid-State With Fe Inside The C-60 Cage (1992)

By carrying out contact-arc vaporization of graphite in a partial atmosphere of Fe(CO)5, an iron-adduct with C60 has been obtained. The adduct has been characterized by various techniques including mass spectrometry, Fe-57 Mossbauer spectroscopy and Fe K-EXAFS. Properties of this adduct are compared with those of an adduct prepared by solution method where Fe is clearly outside the cage. Results suggest that FeC60 obtained from the gas phase reaction has the Fe atom in the cage.
A 1.3 mW 48 MHz 4 Channel MIMO Baseband Receiver With 65 dB Harmonic Rejection and 48.5 dB Spatial Signal Separation (2016)

A four-channel multi-input multi-output (MIMO) complex baseband receiver for spectrum and space-aware cognitive radio applications is presented. The MIMO baseband receiver comprises a capacitive harmonic-rejection downconverting mixer (HRM) receiver and a signal-separation multi-input multi-output analog core (MAC) on a single integrated circuit. The HRM receiver performs frequency selection of the incoming RF signals by programmable spectral downconversion and filtering with minimal harmonic folding. The subsequent MAC separates the spectrally overlapping but spatially diverse signals by weighted complex matrix multiplication. The entire signal path is implemented using energy-efficient g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> -C analog circuits with digitally controlled capacitive weighting for configurable baseband down-/upconversion ranging from -24 to +24 MHz in the HRM, and programmable spatial filtering with 4×4 complex (8×8 real) 14-bit coefficients in the MAC. Measurements demonstrate greater than 65 dB harmonic-folding rejection by the HRM, and greater than 48.5 dB spatial signal separation by the MAC. The 65 nm CMOS IC occupies 3.27 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> active area, and consumes 480 μW digital power at 45 MHz LO and 840 μW analog power at 3 MHz baseband from a 1.2 V supply.
Mobile robot teleoperation system based on remote reality (2011)

Remote Reality (RR) system was designed based on omni-directional vision, which was used for mobile robot teleoperation. In order to improve the human-computer interaction, Augmented Reality (AR) was introduced to the remote reality to form ARR system. With multiple interactive inputs to control and intervene the mobile robot, and use the principle of 3D registration of AR and a fast approximate algorithm to enhance the man-computer interface with overlaid contextual information. The experimental results show that the ARR improves visual effects of the monitoring interface and has annotation-based assistance information to enhance the capacity of human-computer interaction.
Synthesis of 2-(<i>N</i>-Acetylamino)-2-deoxy-<i>C</i>-glucopyranosyl Nucleosides as Potential Inhibitors of Chitin Synthases (2000)

The C-glucopyranosyl nucleosides (1-4) containing the N-acetyl glucosaminyl and uridine units have been synthesized as nonhydrolyzable substrate analogues of UDP-GlcNAc aimed to inhibit the chitin synthases. The key intermediate, 4-(2'-(N-acetylamino)-3', 4',6'-tri-O-benzyl-2'-deoxy-alpha-D-glucopyranosyl)but-2-enoic acid (5), was prepared from the perbenzylated (N-acetylamino)-alpha-C-allylglucoside (7), by successive oxidative cleavage, Wittig olefination, and ester deprotection. The coupling of the acid 5 with the hydroxyl or amine function of the uridine derivatives (6a or 6b) afforded, respectively, the ester 12 and amide 14. The dihydroxylation of the conjugated double bond in ester 12 or amide 14 was better achieved with osmium tetraoxide/barium chlorate, leading to the expected diols 13 and 15 as a mixture of two diastereoisomers. The desired compounds 1-4 were obtained after catalytic hydrogenation of compounds 12-15.
Optimization of TLM schemes based on the general symmetrical condensed node (1997)

A general symmetrical condensed node (GSCN) for the transmission-line modeling (TLM) method is derived from first principles, based on the establishment of a mapping between field quantities and voltage pulses, averaging at the node centers quantities at the boundaries and differencing of Maxwell's equations. The degrees of freedom offered by this formulation permit the development of adaptable nodes, where the mix of stubs and links can be chosen in a manner to optimize the dispersion characteristics. Results are shown confirming that the adaptable nodes can reduce substantially the dispersion and remove polarization-dependent errors.
Quantitative Determination of BTEX and Total Aromatic Compounds in Gasoline by Comprehensive Two-Dimensional Gas Chromatography (GC×GC) (1999)

Comprehensive two-dimensional gas chromatography (GC×GC) has been applied to the quantitative analysis of benzene, toluene, ethylbenzene, xylenes (BTEX), and all heavier aromatic compounds in gasoline. The two-dimensional chromatographic separation used volatility selection on the first-dimension column and polarity selection on the second-dimension column. In the resulting GC×GC chromatogram, aromatic species were resolved from other compound classes. Moreover, structurally related aromatics were grouped in a manner that facilitated identification and integration. The response of a flame ionization detector to each major aromatic group in gasoline was calibrated using internal standards. Quantitation produced results directly comparable with ASTM standard methods. The present GC×GC method can be expanded to analyze other gasoline components.
Is the Low-Tuition Principle Outmoded? (1960)

Eldon L. Johnson, Is the Low-Tuition Principle Outmoded?, The Review of Economics and Statistics, Vol. 42, No. 3, Part 2. Higher Education in the United States: The Economic Problems (Aug., 1960), pp. 44-47
Activity of C-7 Substituted Cyclic Acetal Derivatives of Mitomycin C and Porfiromycin Against Hypoxic and Oxygenated EMT6 Carcinoma Cells <i>In Vitro</i> and <i>In Vivo</i> (1991)

A series of cyclic acetal derivatives of mitomycin C (MC) and porfiromycin (POR) were tested for their ability to kill hypoxic and oxygenated EMT6 tumor cells. Amino methyl acetal and thioacetal substitutions at C-7 of MC and POR dramatically increased the cytotoxicity of the compounds to hypoxic EMT6 tumor cells in vitro but had little effect on the aerobic toxicities. In contrast, a methyl substitution at N1a markedly decreased the aerobic cytotoxicities of the compounds but did not alter the hypoxic cytotoxicities. The POR acetal, BMY-42355, had the largest differential between hypoxic and aerobic cytotoxicities yet observed among MC analogs. Preliminary studies in mice showed that BMY-42355 had good antineoplastic activity when used alone or in combination with radiation and was less toxic than POR; the therapeutic ratio of this compound in these initial studies was higher than those of either MC or POR.
Synthesis and Characterization of Poly(ethylene glycol)−Insulin Conjugates (2000)

Human insulin was modified by covalent attachment of short-chain (750 and 2000 Da) methoxypoly (ethylene glycol) (mPEG) to the amino groups of either residue PheB1 or LysB29, resulting in four distinct conjugates: mPEG(750)-PheB1-insulin, mPEG(2000)-PheB1-insulin, mPEG(750)-LysB29-insulin, and mPEG(2000)-LysB29-insulin. Characterization of the conjugates by MALDI-TOF mass spectrometry and N-terminal protein sequence analyses verified that only a single polymer chain (750 or 2000 Da) was attached to the selected residue of interest (PheB1 or LysB29). Equilibrium sedimentation experiments were performed using analytical ultracentrifugation to quantitatively determine the association state(s) of insulin derivatives. In the concentration range studied, all four of the conjugates and Zn-free insulin exist as stable dimers while Zn(2+)-insulin was exclusively hexameric and Lispro was monomeric. In addition, insulin (conjugate) self-association was evaluated by circular dichroism in the near-ultraviolet wavelength range (320-250 nm). This independent method qualitatively suggests that mPEG-insulin conjugates behave similarly to Zn-free insulin in the concentration range studied and complements results from ultracentrifugation studies. The physical stability/resistance to fibrillation of mPEG-insulin conjugates in aqueous solution were assessed. The data proves that mPEG(750 and 2000)-PheB1-insulin conjugates are substantially more stable than controls but the mPEG(750 and 2000)-LysB29-insulin conjugates were only slightly more stable than commercially available preparations. Circular dichroism studies done in the far ultraviolet region confirm insulin's tertiary structure in aqueous solution is essentially conserved after mPEG conjugation. In vivo pharmacodynamic assays reveal that there is no loss in biological activity after conjugation of mPEG(750) to either position on the insulin B-chain. However, attachment of mPEG(2000) decreased the bioactivity of the conjugates to about 85% of Lilly's HumulinR formulation. The characterization presented in this paper provides strong testimony to the fact that attachment of mPEG to specific amino acid residues of insulin's B-chain improves the conjugates' physical stability without appreciable perturbations to its tertiary structure, self-association behavior, or in vivo biological activity.
Media Manipulations and the Culture of Beneficial Fungal Root Endophytes (2015)

Fungal endophytes have great potential as biocontrol and biofertilisation agents for food crops, and it is important to understand and optimise the cultural conditions for endophyte emergence and growth. A range of commercial culture media were tested for their effect on endophyte recovery from the roots of their host (Hordeum murinum), and for their subsequent growth and sporulation. Furthermore, a medium composed of sterile or filtered whole plant extract (WPE) was tested at various dilutions both alone and in combination with one of the commercial media. It was found that there were significant differences between the media in endophyte recovery, endophyte mycelial growth and time to sporulation. A significantly greater number of different endophytes were recovered from roots on the malt extract plus WPE medium than any of the other media tested here. Sabouraud medium gave the greatest mean radial growth of endophyte fungal mycelia after 35 days. The cultures growing on the WPE media took over five times longer to sporulate than all other media. Results indicate that different media are suitable either for the initial recovery and isolation of fungal root endophytes or for increasing fungal biomass and inducing earlier sporulation. The experimental endophytes used here have previously been shown to have biocontrol and biofertilisation benefits for barley cultivars, so our findings have important implications for the development and commercialisation of endophyte inocula.
Robust channel estimator for MIMO-OFDM systems with FPGA implementation (2008)

Multiple-input multiple- output (MIMO) and orthogonal frequency division multiplexing (OFDM) are two key techniques for broadband wireless mobile communications. In order to provide accurate channel state information (CSI) to support MIMO-OFDM transmission in doubly-selective fading channels, we propose the robust channel estimator based on two-dimensional enhanced discrete-time Fourier transform interpolation (2D-EDFTI), which needs no channel statistics and can improve the channel estimation accuracy significantly. In order to validate its performance in practice, we implement it into our real-time FPGA testbed of 4-by-4 MIMO-OFDM. Also, channel estimator based on two-dimensional linear interpolation (2D-LI) is implemented for comparison. Experiments demonstrate that our proposed 2D-EDFTI channel estimator is robust to doubly-selective fading channels and its performance is always superior to 2D-LI channel estimator. Therefore, MIMO-OFDM transmission by spatial multiplexing with different kinds of MIMO detector, i.e., zero-forcing (ZF) and dynamic layer-ordering m-path detection (DOM), can be well supported.
Is 60 Days of Ciprofloxacin Administration Necessary for Postexposure Prophylaxis for <i>Bacillus anthracis</i> ? (2008)

Sixty days of ciprofloxacin administration at 500 mg every 12 h is currently recommended for the prophylaxis of inhalational exposure to Bacillus anthracis. We examined Bacillus anthracis (Delta-Sterne strain) in our hollow-fiber infection model. We measured the ciprofloxacin concentrations achieved and the number of organisms present before heat shock (total population) and after heat shock (spore population). We fit a mathematical model to these data. Monte Carlo simulation with differing initial spore burdens (3, 5, and 6.9 log(10) CFU/ml) demonstrated that 35 days of this regimen would completely clear the spore burden in 95% of patients. Durations of 110 days did not achieve 99.9% eradication, irrespective of initial burden, because of between-patient variance in drug pharmacokinetics. Given the absence of person-to-person transmission for Bacillus anthracis, adverse drug effects with long-term ciprofloxacin administration, and the possibility of engendering resistance in bodily flora, shorter prophylaxis duration should be given consideration, along with careful monitoring of all exposed individuals.
Up-regulation of Brain-Derived Neurotrophic Factor Expression by Brimonidine in Rat Retinal Ganglion Cells (2002)

<h3>Objectives</h3> Brimonidine tartrate ophth, an α<sub>2</sub>-adrenergic agonist, is widely used as an antiglaucoma agent for lowering intraocular pressure. Recent studies suggest that brimonidine may be neuroprotective for retinal ganglion cells (RGCs) following optic nerve crush injury. Brain-derived neurotrophic factor (BDNF), a potent neuroprotective factor present in the RGCs, promotes RGC survival in culture and following optic nerve injury. We tested the hypothesis that a possible mechanism of brimonidine neuroprotection is through up-regulation of endogenous BDNF expression in the RGCs. <h3>Methods</h3> A single dosage of brimonidine tartrate ophth solution (0.85-34µM) was injected intravitreally into Sprague-Dawley rat eyes. The fellow eyes of each animal were injected with balanced salt solution (BSS) and used as control eyes. To determine BDNF messenger RNA expression, animal eyes were enucleated and processed for in situ hybridization, or retinas were isolated and processed for Northern blot analysis using rat BDNF radiolabeled riboprobes. <h3>Results</h3> In the control eyes injected with saline, BDNF was present in a minority of the RGCs. Two days after brimonidine injection, the number of BDNF-positive RGCs was increased from 55% to 166%, depending on brimonidine concentrations, when compared with those in the controls. In addition, the BDNF signal intensities in individual RGCs were elevated 50% in brimonidine-injected eyes compared with control eyes. Northern blot revealed a 28% increase of BDNF expression in the brimonidine group compared with the controls (<i>P</i><.003). No significant difference was observed in BDNF receptor,<i>trk</i>B, expression between brimonidine, or BSS control groups. <h3>Conclusions</h3> A single dose of a low concentration of intravitreal brimonidine is sufficient to significantly increase endogenous BDNF expression in RGCs. These results suggest that brimonidine neuroprotection may be mediated through up-regulation of BDNF in the RGCs. The BDNF should be further investigated regarding its role in the neuroprotective effects reported with brimonidine. <h3>Clinical Relevance</h3> Brimonidine may be (potentially) used clinically as a neuroprotective agent in optic neuropathy, including glaucoma, and ischemic and traumatic optic neuropathy.
The Postprocessor Technology of for 5-axis Control Machining (2011)

In order to develop a practical postprocessor for 5-axis machining, the general equations of numerically controlled (NC) data for 5-axis configurations with not only non-orthogonal rotary axes but also orthogonal rotary axes were exactly expressed by the inverse kinematics, and a Windows-based postprocessor written in Visual Basic was developed according to the proposed algorithm. The developed postprocessor is a general system that suitable for all kinds of 5-axis machine tool with orthogonal and non-orthogonal rotary axes. Through implementation of the developed postprocessor and verification by a cutting simulation and machining experiment, the effectiveness of the proposed algorithm is confirmed. Compatibility is improved by allowing exchange of data formats such as rotational tool center position (RTCP) controlled NC data, vector post NC data, and program object file (POF) cutter location (CL)data, and convenience is increased by adding the function of work-piece origin offset. Consequently, the technology of practical post-processor for 5-axis machining is developed.
A test of crystal structure prediction of small organic molecules (2000)

A collaborative workshop was held in May 1999 at the Cambridge Crystallographic Data Centre to test how well currently available methods of crystal structure prediction perform when given only the atomic connectivity for an organic compound. A blind test was conducted on a selection of four compounds and a wide range of methodologies representing, the principal computer programs currently available were used. There were 11 participants who were allowed to propose at most three structures for each compound. No program gave consistently reliable results. However, seven proposed structures were close to an experimental one and were classified as "correct". One compound occurred in two polymorphs, but only one form was predicted correctly among the calculated structures. The basic problem with lattice energy based methods of crystal structure prediction is that many structures are found within a few kJ mol(-1) of the global minimum. The fine detail of the force-field methodology and parametrization influences the energy ranking within each method. Nevertheless, present methods may be useful in providing a set of structures as possible polymorphs for a given molecular structure.
Towards a point-of-care diagnostic system (2011)

Many of the diagnostic tests administered in well-funded clinical laboratories are inappropriate for point-of-care testing in low-resource environments. As a result, inexpensive, portable immunoassay tests have been developed to facilitate the rapid diagnosis of many diseases common to developing countries. However, manually analyzing the test results at the point of care may be complex and error-prone for untrained users reading test results by eye, and providing methods for automatically processing these tests could significantly increase their utility. In this paper, we present a mobile application that automatically quantifies immunoassay test data on a smart phone. The speed and accuracy demonstrated by the application suggest that cell-phone based analysis could aid disease diagnosis at the point of care.
Transition Metal-Catalyzed Silanone Generation (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTransition Metal-Catalyzed Silanone GenerationRoman Goikhman, Michael Aizenberg, Linda J. W. Shimon, and David MilsteinView Author Information Departments of Organic Chemistry and Chemical Services The Weizmann Institute of Science Rehovot 76100, IsraelCite this: J. Am. Chem. Soc. 1996, 118, 44, 10894–10895Publication Date (Web):November 6, 1996Publication History Received29 July 1996Published online6 November 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja9626087https://doi.org/10.1021/ja9626087rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views570Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysis,Elimination reactions,Ketones,Organic reactions,Reductive elimination Get e-Alerts