gebhart/patrepeval huggingface dataset:
Microstructure induced magnetic anisotropy in Fe/Cr (110) superlattices (1993)

A special corrugated microstructure of Fe/Cr(110) superlattices is discovered, which develops spontaneously when grown on Ge(110) substrates. This microstructure was studied using low energy electron diffraction and transmission electron microscopy. Also magnetic and transport properties of these superlattices were measured. We conclude that the microstructure induces a magnetic anisotropy, which has a strong influence on the magnetoresistance curves.
A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea (2013)

Ondansetron relieves some of the most intrusive symptoms of IBS-D, namely loose stools, frequency and urgency.
Chelating NHC Ruthenium(II) Complexes as Robust Homogeneous Hydrogenation Catalysts (2009)

A series of ruthenium(II) complexes have been prepared by using bidentate chelating N-heterocyclic carbene (NHC) ligands that feature different donor groups E (E = olefin, thioether, carboxylate, and NHC). Rigid coordination of all donor sites was concluded from NMR spectroscopy, and the electronic impact of the donor group was evaluated by electrochemical analyses. The chelating donor group had a strong influence on the activity of the metal center in catalyzing direct hydrogenation of styrene. A thioether group or a second NHC donor site essentially deactivates the metal center. Complexes comprising a NHC tethered with an olefin or a carboxylate group showed appreciable activity, though only the carboxylate-functionalized system proved to be a precursor for homogeneous hydrogenation. According to in situ high-pressure NMR analyses, complexes featuring a carboxylate chelating group are remarkably resistant toward reductive elimination even under strongly reducing conditions and may, therefore, be used repeatedly.
New software for searching the Cambridge Structural Database and visualizing crystal structures (2002)

Two new programs have been developed for searching the Cambridge Structural Database (CSD) and visualizing database entries: ConQuest and Mercury. The former is a new search interface to the CSD, the latter is a high-performance crystal-structure visualizer with extensive facilities for exploring networks of intermolecular contacts. Particular emphasis has been placed on making the programs as intuitive as possible. Both ConQuest and Mercury run under Windows and various types of Unix, including Linux.
The Haptic steering Wheel: Vibro-tactile based navigation for the driving environment (2010)

Over the past few years, several studies have been made on haptic devices that help people focus on driving and increase safety. In this paper, we propose a vibro-tactile based display on a steering wheel named “The Haptic Wheel”, which is embedded with 32 linear actuators to present tactile information such as “Alert”, “Turn left” and “Turn right”. This information is coded with spatial and temporal patterns, resulting in the transfer of information regardless of the holding gesture and the number of hands gripping the steering wheel. This noble interface allows users to get information through the physical contact of the driver's palm, a part of the body that is free from objects such as clothes or shoes. We conducted an experiment to evaluate three proposed stimuli modes with no tactile illusion, phantom illusion or sensory saltation. Experimental results show that the influence of design parameters of which had greater differences for transferring navigation information. This study gives a meaningful indication that employing the tactile display on the steering wheel can give directional information to the driver.
Untangling the Web: Toxic and Protective Effects of Neuroinflammation and PGE<sub>2</sub> Signaling in Alzheimer’s Disease (2016)

The neuroinflammatory response has received increasing attention as a key factor in the pathogenesis of Alzheimer's disease (AD). Microglia, the innate immune cells and resident phagocytes of the brain, respond to accumulating Aβ peptides by generating a nonresolving inflammatory response. While this response can clear Aβ peptides from the nervous system in some settings, its failure to do so in AD accelerates synaptic injury, neuronal loss, and cognitive decline. The complex molecular components of this response are beginning to be unraveled, with identification of both damaging and protective roles for individual components of the neuroinflammatory response. Even within one molecular pathway, contrasting effects are often present. As one example, recent studies of the inflammatory cyclooxygenase-prostaglandin pathway have revealed both beneficial and detrimental effects dependent on the disease context, cell type, and downstream signaling pathway. Nonsteroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenases, are associated with reduced AD risk when taken by cognitively normal populations, but additional clinical and mouse model studies have added complexities and caveats to this finding. Downstream of cyclooxygenase activity, prostaglandin E2 signaling exerts both damaging pro-inflammatory and protective anti-inflammatory effects through actions of specific E-prostanoid G-protein coupled receptors on specific cell types. These complexities underscore the need for careful study of individual components of the neuroinflammatory response to better understand their contribution to AD pathogenesis and progression.
Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) <i>n</i>‐butoxyethylpyridylporphyrin‐based redox modifier (2016)

Combinations of radiotherapy (RT) and chemotherapy have shown efficacy toward brain tumors. However, therapy-induced oxidative stress can damage normal brain tissue, resulting in both progressive neurocognitive loss and diminished quality of life. We have recently shown that MnTnBuOE-2-PyP(5+) (Mn(III)meso-tetrakis(N-n-butoxyethylpyridinium -2-yl)porphyrin) rescued RT-induced white matter damage in cranially-irradiated mice. Radiotherapy is not used in isolation for treatment of brain tumors; temozolomide is the standard-of-care for adult glioblastoma, whereas cisplatin is often used for treatment of pediatric brain tumors. Therefore, we evaluated the brain radiation mitigation ability of MnTnBuOE-2-PyP(5+) after either temozolomide or cisplatin was used singly or in combination with 10 Gy RT. MnTnBuOE-2-PyP(5+) accumulated in brains at low nanomolar levels. Histological and neurobehavioral testing showed a drastic decrease (1) of axon density in the corpus callosum and (2) rotorod and running wheel performance in the RT only treatment group, respectively. MnTnBuOE-2-PyP(5+) completely rescued this phenotype in irradiated animals. In the temozolomide groups, temozolomide/ RT treatment resulted in further decreased rotorod responses over RT alone. Again, MnTnBuOE-2-PyP(5+) treatment rescued the negative effects of both temozolomide ± RT on rotorod performance. While the cisplatin-treated groups did not give similar results as the temozolomide groups, inclusion of MnTnBuOE-2-PyP(5+) did not negatively affect rotorod performance. Additionally, MnTnBuOE-2-PyP(5+) sensitized glioblastomas to either RT ± temozolomide in flank tumor models. Mice treated with both MnTnBuOE-2-PyP(5+) and radio-/chemo-therapy herein demonstrated brain radiation mitigation. MnTnBuOE-2-PyP(5+) may well serve as a normal tissue radio-/chemo-mitigator adjuvant therapy to standard brain cancer treatment regimens. Environ. Mol. Mutagen. 57:372-381, 2016. © 2016 Wiley Periodicals, Inc.
Selective Vibration Sensing: A New Concept for Activity‐Sensing Rate‐Responsive Pacing (1988)

A clinically available model of an activity-sensing, rate-responsive pacemaker (Activitrax, Medtronic) utilizes body vibration during exercise as an indicator of the need for a rate increase. Although having the advantage of rapid onset of rate response, this system lacks specificity and the rate response does not closely correlate with the level of exertion. In addition, this pacemaker is susceptible to the effects of extraneous vibration. In this study involving 20 normal subjects fitted with an external Activitrax pacemaker, the rate responses to a variety of exercises were studied and were compared with the corresponding sinus rates. The vibration generated at the level of the pacemaker was also measured by accelerometers in three axes. Only a fair correlation (r = 0.51) was achieved between the pacemaker rate and the sinus rate. The total root mean square value of acceleration in either the anteroposterior or the vertical axes was found to have a better correlation (r = 0.8). As the main accelerations during physical activities were in the lower frequency range (0.1-4 Hz), a low-pass filter was used to reduce the influence of extraneous vibration. Selective sensing of the acceleration level may be usefully implemented in an algorithm for activity pacing.
Nonsteroidal anti-inflammatory drug gastropathy: new avenues for safety (2011)

Chronic oral or systemic nonselective nonsteroidal anti-inflammatory drug (NSAID) therapy, ubiquitously used by physicians to treat osteoarthritis-associated pain, is associated with a wide range of symptomatic adverse events, the most frequent and serious of which is gastropathy. Although cardiovascular and renal problems are a very real concern, they are significantly less frequent. These complications can be life-threatening in at-risk populations such as older adults, who are common users of long-term oral systemic NSAID therapy. Topical NSAID formulations deliver effective doses of analgesics directly to the affected joints, thereby limiting systemic exposure and potentially the risk of systemic adverse events, such as gastropathy and serious cardiovascular events. There are currently two topical NSAIDs approved by the US Food and Drug Administration for osteoarthritis-associated pain, as well as for the signs and symptoms of osteoarthritis. This review discusses the relative safety, and the gastrointestinal, cardiovascular, and renal risks of chronic oral or systemic NSAID therapy and topical NSAID formulations in patients with osteoarthritis.
T.D.M. transmission of programme channels (1965)

A programme channel requires greater bandwidth than a normal telephone speech channel. It can be accommodated in a time-division multiplex (t.d.m.) transmission system by using the pulse trains of several speech channels. The paper shows that, when these pulse trains are not equally spaced, distortion components are produced in the output signal.In general, the distortion components are at the channel pulse-repetition frequency and its harmonics, together with upper and lower sideband components. To obtain a sufficiently low distortion level, the permissible departures from equal pulse spacing are only of the order of ±1° or less. Similar distortion is also introduced if the pulses are not identical in height and shape. To obtain sufficiently low distortion level, the differences in height and length of the pulses used for a programme channel may only be of the order of 1%.Although the analysis is made for t.d.m. systems using pulse-amplitude modulation (p.a.m.), its results are shown to be applicable to some systems using other forms of modulation, such as pulse-code modulation (p.c.m.). It is concluded that p.c.m. systems are unsuitable for programme transmission unless the total number of time slots per frame (including synchronising pulses) is an exact multiple of the number of speech channels required to constitute a programme channel.
Dielectric Properties of 2,3-Dicyano-4-pentyloxyphenyl 4′-pentyloxybenzoate (DPP) Mixtures with Non-polar Liquid Crystals (LC) (1983)

Abstract The static dielectric properties of four binary mixtures of DPP and non-polar LC were investigated. For each system the effective dielectric anisotropy of DPP was calculated by means of linear extrapolation. The essential influence of the polarizability of non-polar LC molecule on the effective value of DPP dielectric anisotropy was shown. The influence of non-polar LC matrix on the effective value of the dielectric permittivity of DPP is discussed.
Mechanical and Thermal Properties of High Density Polyethylene – Dried Distillers Grains with Solubles Composites (2012)

Dried Distillers Grain with Solubles (DDGS) was evaluated as a biobased fiber reinforcement. Composites of high density polyethylene (HDPE) composed of 25% by weight DDGS and either 0% or 5% by weight of maleated polyethylene (MAPE) were produced by twin screw compounding and injection molding. An improved DDGS bio-filler was produced by solvent treating DDGS (STDDGS). Injection-molded test specimens were evaluated for their tensile, flexural, impact, and thermal properties. Composite blends composed of STDDGS were superior to their DDSG counterparts. Composites made with STDDGS and MAPE had significantly improved tensile and flexural properties compared to neat HDPE. Impact strength of all composites was similar and lower than neat HDPE. Soaking of tensile bars of the various PE-DDGS blends in distilled water for 28 days altered their physical, color, and mechanical properties. Differential scanning calorimetery and thermogravimetric analysis were conducted on neat HDPE and DDGS composites to evaluate their thermal properties.
Translating While Parsing (2006)

Translations-unconsciously-rely on the hypothesis that sentences of a certain source language L S can be expressed by sentences of the target language L T .Formal theories of semantics, on the other hand, assume that semantics is computed compositionally: the meaning of an expression is a function of the meaning of its parts.A standard argument for the compositionality of meaning is productivity.Formal semantic compositionality has been formalized by the rule-to-rule hypothesis of Bach (1976).The idea is wellknown from the Montague grammars.The meaning of idioms is, however, not a function of its parts: its meaning has to be learnt as a unit.Combining the basic idea of translation with the rule-to-rule hypothesis, we can express structures of language L S in language L T .These structures of L T -called translations-can also be either computed compositionally or as units: each syntactic rule of L S should have its counterpart expressed-not by semantic rules, but-by syntactic descriptions in language L T .
Implementation of AES S-Boxes using combinational logic (2008)

In this paper, two approaches for implementation of the 8-bit S-Box suitable for FPGA based solutions are considered. These use (a) synthesis of the logic functions using Boolean simplification of the truth table of all the columns and (b) synthesis of the ANF (Algebraic Normal form) logic functions using AND and EXOR gates. The hardware and computation time evaluation for both the options are also presented.
Fabrication of ZnS∕SiC nanocables, SiC-shelled ZnS nanoribbons (and sheets), and SiC nanotubes (and tubes) (2004)

Here we report on the synthesis of ZnS∕SiC nanocables and SiC nanotubes and other relevant structures via a controllable two-stage thermal process using ZnS nanowires, nanoribbons, and sheets as templates. Within the cables, the ZnS cores are polytypes of fcc- and hcp-ZnS with ∼50–130nm diameter, and the SiC shells are polycrystalline β-SiC with ∼15–50nm thickness. SiC nanotubes were formed through simple removal of ZnS cores from the cables. Room-temperature photoluminescence of the SiC nanotubes displays a strong green emission band centered at ∼517nm. The nanostructures described herewith may be valuable in the blocks of advanced semiconducting devices.
A unified version model for configuration management (1995)

article A unified version model for configuration management Share on Author: Andreas Zeller Technische Universität Braunschweig, Abteilung Softwaretechnologie, Gauβstr. 17, D-38092 Braunschweig/Germany Technische Universität Braunschweig, Abteilung Softwaretechnologie, Gauβstr. 17, D-38092 Braunschweig/GermanyView Profile Authors Info & Claims ACM SIGSOFT Software Engineering NotesVolume 20Issue 4Oct. 1995 pp 151–160https://doi.org/10.1145/222132.222151Online:01 October 1995Publication History 19citation704DownloadsMetricsTotal Citations19Total Downloads704Last 12 Months3Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Synthesis and in vitro degradation of poly(alkylene carbonate anhydride) (2000)

A novel degradable poly(alkylene carbonate anhydride) (PACA) was synthesized by the melt polycondensation reaction of the corresponding mixed anhydrides of the dicarboxylic acid derived from oligo(tetramethylene carbonate)diol (OTMCD) and oligo(hexamethylene carbonate)diol (OHMCD). The polymer's structure was confirmed by IR and 1H NMR spectroscopy. DSC analysis showed PACA had a low Tg (< –30°C). In vitro degradation tests indicated that the degradation rate of poly(alkylene carbonate) was more controlled with the incorporation of anhydride groups.
Defucosylation of Tumor-Specific Humanized Anti-MUC1 Monoclonal Antibody Enhances NK Cell-Mediated Anti-Tumor Cell Cytotoxicity (2021)

Antibodies are commonly used in cancer immunotherapy because of their high specificity for tumor-associated antigens. The binding of antibodies can have direct effects on tumor cells but also engages natural killer (NK) cells via their Fc receptor. Mucin 1 (MUC1) is a highly glycosylated protein expressed in normal epithelial cells, while the under-glycosylated MUC1 epitope (MUC1-Tn/STn) is only expressed on malignant cells, making it an interesting diagnostic and therapeutic target. Several anti-MUC1 antibodies have been tested for therapeutic applications in solid tumors thus far without clinical success. Herein, we describe the generation of fully humanized antibodies based on the murine 5E5 antibody, targeting the tumor-specific MUC1-Tn/STn epitope. We confirmed that these antibodies specifically recognize tumor-associated MUC1 epitopes and can activate human NK cells in vitro. Defucosylation of these newly developed anti-MUC1 antibodies further enhanced antigen-dependent cellular cytotoxicity (ADCC) mediated by NK cells. We show that endocytosis inhibitors augment the availability of MUC1-Tn/STn epitopes on tumor cells but do not further enhance ADCC in NK cells. Collectively, this study describes novel fully humanized anti-MUC1 antibodies that, especially after defucosylation, are promising therapeutic candidates for cellular immunotherapy.
Query optimization in distributed logic-oriented object bases (2003)

A logic-oriented object base is defined to be a deductive database based on an object data model. Like conventional databases, logic-orientated object bases can be constructed on top of computer networks in such a way that the distribution of logical and physical components of the system is kept hidden from the users. Objects are organized hierarchically and are retrieved through customized methods. The problem of query optimization in such an environment is investigated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Trends in thrombolytic use for ischemic stroke in the United States (2010)

Although tPA administration for ischemic stroke has increased nationally in recent years, the overall rate of use remains very low. Larger hospitals were more likely to administer tPA. Further efforts to improve appropriate administration of tPA should be encouraged, particularly as the acceptable time-window for using tPA widens.
Neural Rewards Regression for Near-optimal Policy Identification in Markovian and Partial Observable Environments (2007)

Abstract. Neural Rewards Regression (NRR) is a generalisation of Temporal Difference Learning (TD-Learning) and Approximate Q-Iteration with Neural Networks. The method allows to trade between these two techniques as well as between approaching the fixed point of the Bellman iteration and minimising the Bellman residual. NRR explicitly finds a near-optimal Q-function without an algorithmic framework except Back Propagation for Neural Networks. We further extend the approach by a recurrent substructure to Recurrent Neural Rewards Regression (RNRR) for partial observable environments or higher order Markov Decision Processes. It allows to transport past information to the present and the future in order to reconstruct the Markov property. 1
Melatonin synthesis pathway: circadian regulation of the genes encoding the key enzymes in the chicken pineal gland and retina (1999)

The mRNAs encoding three enzymes of the melatonin synthesis pathway (tryptophan hydroxylase (TPH), arylalkylamine-N-acetyltransferase (AANAT) and hydroxyindole-O-methyl-transferase (HIOMT)) are expressed with a day/night rhythm in the chicken pineal gland and retina. TPH and AANAT mRNA levels reach their peak at night. HIOMT mRNA levels peak at night in the retina, but during the day in the pineal gland. In this tissue, the rhythm of TPH, AANAT and HIOMT mRNA levels persisted in constant darkness (DD), both in vivo and in vitro, indicating that the three genes are controlled by the circadian oscillator of the chicken pineal. In the retina, the rhythms of TPH and AANAT mRNA levels also persisted in DD in vivo, suggesting that they are driven by a circadian oscillator. In contrast, the rhythm of HIOMT mRNA in the retina appeared to be controlled only by light. The clones of chicken AANAT and HIOMT genes that we have isolated should help us to understand the molecular mechanisms of: 1) their transcriptional regulation by circadian oscillators and by light; 2) their tissue-specific expression in the pineal gland and the retina.
Analysis and Design of a Double-Quadrature CMOS VCO for Subharmonic Mixing at $Ka$-Band (2008)

In this paper, we analyze the potentials of a four-phase 14-GHz CMOS voltage-controlled oscillator, tailored to a sub-harmonic receiver, for signal processing at Ka-band. When mild phase accuracies between in-phase and quadrature down-converted signals are required, the four-phase oscillator displays roughly the same phase noise figure-of-merit as quadrature oscillator counterparts. However, the operation at half-frequency leads to an improved performance due to a higher quality factor of the tuning varactors, and because the local oscillator circuitry and signal path run at different frequencies, relaxing coupling issues. A detailed time-variant analysis of phase noise in multiphase oscillators is introduced and validated by both simulations and experiments. Prototypes realized in a 65-nm technology occupy an active area of 0.5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and show the following performances: a 26% frequency tuning range (from 12.2 to 15.9 GHz), maximum phase error from pi/4 of 2deg, and a phase noise of -110 dBc/Hz at 1 MHz from 14 GHz, while consuming 18 mA from 0.8-V supply.
Origin of Seeded Endothelial Cells (1989)

This study proposes to evaluate the effectiveness of porcine endothelial cell seeding on the patency rate and the cellular lining of healed grafts. Nonseeded grafts were implanted in a series of 8 dogs while porcine endothelial cell-seeded grafts were used in 15 animals. Aspirin (325 mg) was given daily to all animals. The thirty-two-day patency rate was 25% (2/8) versus 67% (10/15) respectively for the control and seeded grafts (p < .01). All patent grafts were lined with an endothelial surface. Cultures of the thirty-two-day old seeded grafts grew a combination of canine and porcine cells at a ratio of 5/1. The authors conclude that allograft cell seeding increases the patency rate of vena cava grafts and may stimulate growth of host canine cells. No clinical adverse reactions were noted with allograft cell seeding in the present study.