gebhart/patrepeval huggingface dataset:
Affinity-Purified Escherichia Coli J5 Lipopolysaccharide-Specific Igg Protects Neutropenic Rats Against Gram-Negative Bacterial Sepsis (1994)

Antibodies were raised in rabbits by immunization with the heat-killed J5 mutant of Escherichia coli O111 (Rc chemotype). Serum antibodies were separated into purified IgG and IgM by sequential affinity chromatography on protein G-Sepharose and anti-rabbit IgG-Sepharose columns. J5 lipopolysaccharide (LPS)-specific IgG was prepared by affinity chromatography of purified IgG on a J5 LPS-EAH Sepharose 4B affinity column. Purified IgM, IgG, and J5 LPS-specific IgG protected neutropenic rats against lethal challenge with Pseudomonas aeruginosa 12:4:4 (Fisher Devlin immunotype 6). Nine of 16 rats treated with the IgM fraction were protected (P < .001). Thirteen of 20 rats treated with the purified IgG and 6 of 8 treated with J5 LPS-specific IgG were protected compared with none of 25 treated with IgG made from the preimmune serum of the same rabbit (P < .001). These results demonstrate that purified J5 LPS-specific IgG protects against the lethal consequences of gram-negative bacteremia.
Control of Prolonged Drug Release and Compression Properties of Ibuprofen Microsponges with Acrylic Polymer, Eudragit RS, by Changing Their Intraparticle Porosity. (1992)

Prolonged-release spherical micro-matrices of ibuprofen with Eudragit RS were prepared using a novel emulsion-solvent diffusion method. Those particles were termed "microspheres" due to their characteristic sponge-like texture and unique dissolution and compression properties unlike conventional microcapsules or microspheres. The internal porosity of microspheres could be easily controlled by changing the concentration of the drug and the polymer in the emulsion droplet (ethanol). With lower concentration of ibuprofen in the ethanol, the resultant microspheres had a higher porosity, about 50%. The drug release rate from the microspheres was interpreted by the Higuchi model of spherical matrices, which depended only on their internal porosity of the microspheres when size distribution and drug content were the same. The tortuosities in the microspheres were found to be almost constant (3-4) irrespective of porosity, suggesting the same internal texture. Microsphere compressibility was much improved over the physical mixture of the drug and polymer owing to the plastic deformation of their sponge-like structure. The more porous microspheres produced stronger tablets [corrected].
Intraoperative Renal Ultrasonography: A Useful Adjunct to Partial Nephrectomy (1991)

Several evolutionary changes in ultrasonographic instrumentation, including miniaturization of transducers and marked improvement in resolution, have made intraoperative renal ultrasonography a valuable adjunct for intrarenal surgery. We investigated its use in 6 patients undergoing partial nephrectomy for treatment of renal cell carcinoma. In addition, 14 kidneys with renal tumors were scanned immediately after radical nephrectomy and the specimens were subjected to simulated partial nephrectomy. Transverse and longitudinal real-time sonographic images were obtained with a 5 MHz. sector scanner or a 7.5 MHz. convex array transducer. With ultrasonography to define tumor extent and location, negative surgical margins were obtained in all 6 individuals undergoing partial nephrectomy. A negative surgical margin was obtained in 13 of the 14 radical nephrectomy specimens subjected to simulated partial nephrectomy. A small satellite lesion was not identified and not resected in 1 of the radical nephrectomy specimens. We found that intraoperative renal ultrasonography helps to identify the location and extent of deep intraparenchymal lesions. It also provides a guide for a more accurate nephrotomy, which facilitates the attainment of negative resection margins during partial nephrectomy.
Improvement in Open-Circuit Voltage for Organic Solar Cells Based on Subphthalocyanines and C60 (2011)

The open-circuit voltage of organic solar cells from 605 to 858 mV based on subphthalocyanines and C60 by adding a hole transporting layer e.g., poly (3,4-ethylenedioxy-thiophene), poly(styrenesulfonate) between the anode and SubPc. Meanwhile, the fill factor and short-circuit current were also optimized resulting in a grate enhancement in power conversion efficiency from 0.65% to 1.4%. Based on the optical transfer matrix theory and resistance study at short-circuit conditions RJsc, the influences of build-in potential, hole injecting barrier on photovoltaic properties have been discussed.
Inflammation and endothelial dysfunction during aging: role of NF-κB (2008)

One of the major conceptual advances in our understanding of the pathogenesis of age-associated cardiovascular diseases has been the insight that age-related oxidative stress may promote vascular inflammation even in the absence of traditional risk factors associated with atherogenesis (e.g., hypertension or metabolic diseases). In the present review we summarize recent experimental data suggesting that mitochondrial production of reactive oxygen species, innate immunity, the local TNF-alpha-converting enzyme (TACE)-TNF-alpha, and the renin-angiotensin system may underlie NF-kappaB induction and endothelial activation in aged arteries. The theme that emerges from this review is that multiple proinflammatory pathways converge on NF-kappaB in the aged arterial wall, and that the transcriptional activity of NF-kappaB is regulated by multiple nuclear factors during aging, including nuclear enzymes poly(ADP-ribose) polymerase (PARP-1) and SIRT-1. We also discuss the possibility that nucleophosmin (NPM or nuclear phosphoprotein B23), a known modulator of the cellular oxidative stress response, may also regulate NF-kappaB activity in endothelial cells.
Metal-Protein Attenuating Compounds (MPACs) for the Treatment of Alzheimers Disease (2004)

Aberrant metal protein interactions leading to the generation of toxic reactive oxygen species and protein denaturation have been implicated in a number of neurodegenerative diseases. A breakdown in metal homeostasis plays a critical role in these disorders including Alzheimers disease (AD), where abnormal interactions of copper and zinc ions with ß-amyloid (Aß) may underlie the pathogenesis. We have developed metal-protein attenuating compounds (MPACs) as a novel class of therapeutic agent that target pathogenic interactions of metals with proteins. The prototype for this class of compound is clioquinol (CQ), a small hydrophobic molecule capable of crossing the blood brain barrier. This compound has been shown to have beneficial effects in both a transgenic mouse model of AD and a recently completed small-scale phase II clinical trial.
Bacteria in milk destroys botulism poison (1928)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBacteria in milk destroys botulism poisonScience Service Cite this: J. Chem. Educ. 1928, 5, 1, 2Publication Date (Print):January 1, 1928Publication History Received3 August 2009Published online1 January 1928Published inissue 1 January 1928https://doi.org/10.1021/ed005p2.2RIGHTS & PERMISSIONSArticle Views34Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (734 KB) Get e-Alerts Get e-Alerts
Effective integration of object tracking in a video coding scheme for multisensor surveillance systems (2003)

This paper deals with the interaction and integration of two important elements of most video surveillance systems: object tracking and video coding. Both elements are open research topics and in general they are studied separately. In the domain of video surveillance the convergence of the two subjects can be extremely important to build viable applications in a number of emerging security scenarios. In this context we propose a spatio-temporal filter based on object tracking that improves coding performances and post-coding analysis. The filter is an alternative to complex object-based video codecs in many video surveillance scenarios. It increases the spatio-temporal redundancies of input signal discarding noise and unwanted moving objects. We demonstrate that the compression performances of successive codecs are increased. Moreover, the decoded stream implicitly represents the regions of interest detected on the original signal.
Phonetic typewriter for Finnish and Japanese (2003)

A microprocessor-based real-time speech recognition system is described. It is able to produce orthographic transcriptions for arbitrary words or phrases uttered in Finnish or Japanese. It can also be used as a large-vocabulary isolated word recognizer. The acoustic processor of the system transcribing speech into phonemes is based on neural network principles. The so-called phonotopic maps constructed by a self-organizing process are employed. The coarticulation effects in phonetic transcriptions are compensated by means of automatically derived rules which describe the morphology of errors at the acoustic processor output. Without applying any language model, the recognition result is correct up to 92 or even 97 per cent referring to individual letters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Fusing Imagery and 3D Point Clouds for Reconstructing Visible Surfaces of Urban Scenes (2007)

The automatic reconstruction of urban scenes from sensory input data is a daunting task. By and large the task remains unresolved, although a considerable amount of research has been devoted to its solution. Many of the proposed methods are either too application dependent, or address only some aspects of the general problem. Moreover it appears that solutions based on a single sensor source, for example intensity images or laser point clouds, lead to partial solutions. In this paper we propose the reconstruction of visible surfaces from multi-sensor data, embedded in a fusion framework. We postulate that the reconstructed surface is an intermediate and application independent representation of the scene, similar to the 2.5 D sketch proposed by Marr in his vision paradigm. In contrast to the viewer based 2.5 D sketch, our reconstructed surface is represented in a suitable 3D Cartesian reference system. It contains explicit surface information, including shape and surface discontinuities. We argue that such an explicit description greatly benefits applications, such as object recognition, populating or updating GIS, change detection, city modeling, and true orthophoto generation. This is because the 3D object space enables more powerful reasoning methods to aid object recognition and image understanding as opposed to the traditional approach of reasoning in the 2D image space. Another strong motivation for the proposed application independent surface reconstruction scheme is the multi-source scenario with imaging and laser point data, and possibly hyperspectral data. These widely disparate data sets contain common (redundant), complementary and occasionally conflicting information about the surface. The paper discusses the notion of different surfaces and their relationships. Major emphasis is placed on the development of a general, true 3D surface representation scheme that copes with the problem of multi layer surfaces (e.g. multiple overpass).
Three-Dimensional Hydrogen Microscopy in Diamond (2004)

A microprobe of protons with an energy of 17 million electron volts is used to quantitatively image three-dimensional hydrogen distributions at a lateral resolution better than 1 micrometer with high sensitivity. Hydrogen images of a <110>-textured undoped polycrystalline diamond film show that most of the hydrogen is located at grain boundaries. The average amount of hydrogen atoms along the grain boundaries is (8.1 +/- 1.5) x 10(14) per square centimeter, corresponding to about a third of a monolayer. The hydrogen content within the grain is below the experimental sensitivity of 1.4 x 10(16) atoms per cubic centimeter (0.08 atomic parts per million). The data prove a low hydrogen content within chemical vapor deposition-grown diamond and the importance of hydrogen at grain boundaries, for example, with respect to electronic properties of polycrystalline diamond.
pH-dependent modulation of Kv1.3 inactivation: role of His399 (2004)

The Kv1.3 K(+) channel lacks N-type inactivation, but during prolonged depolarized periods it inactivates via the slow (P/C type) mechanism. It bears a titratable histidine residue in position 399 (equivalent of Shaker 449), a site known to influence the rate of slow inactivation. As opposed to several other voltage-gated K(+) channels, slow inactivation of Kv1.3 is slowed when extracellular pH (pH(o)) is lowered under physiological conditions. Our findings are as follows. First, when His399 was mutated to a lysine, arginine, leucine, valine or tyrosine, extracellular acidification (pH 5.5) accelerated inactivation reminiscent of other Kv channels. Second, inactivation of the wild-type channel was accelerated by low pH(o) when the ionic strength of the external solution was raised. Inactivation of the H399K mutant was also accelerated by high ionic strength at pH 7.35 but not the inactivation of H399L. Third, after the external application of blocking barium ions, recovery of the wild-type current during washout was slower in low pH(o). Fourth, the dissociation rate of Ba(2+) was pH insensitive for both H399K and H399L. Furthermore, Ba(2+) dissociation rates were equal for H399K and the wild type at pH 5.5 and were equal for H399L and the wild type at pH 7.35. These observations support a model in which the electric field of the protonated histidines creates a potential barrier for potassium ions just outside the external mouth of the pore that hinders their exit from the binding site controlling inactivation. In Kv1.3, this effect overrides the generally observed speeding of slow inactivation when pH(o) is reduced.
Polycrystalline silicon thin-film transistors fabricated by defect reduction methods (2002)

Fabrication of n-channel polycrystalline silicon thin-film transistors (poly-Si TFTs) at a low temperature is reported. 13.56 MHz-oxygen plasma at a 100 W, 130 Pa at 250/spl deg/C for 5 min, and heat treatment at 260/spl deg/C with 1.3/spl times/10/sup 6/-Pa-H/sub 2/O vapor for 3 h were applied to reduction of the density of defect states in 25-nm-thick silicon films crystallized by irradiation of a 30 ns-pulsed XeCl excimer laser. Defect reduction was numerically analyzed. Those treatments resulted in a high carrier mobility of 830 cm/sup 2//Vs and a low threshold voltage of 1.5 V at a laser crystallization energy density of 285 mJ/cm/sup 2/.
Co-implantation of Be+O and Mg+O into GaN (2001)

Beryllium and magnesium were co-implanted with oxygen into GaN at precise donor-to-acceptor ratios of 0.5–2. High activation efficiency was achieved for Be+O co-implants at a donor–acceptor ratio of 2 and anneal temperatures of 1050–1100 °C. The activation process was not a simple, single-step mechanism. Hall data indicated a relatively low (⩽100 meV) ionization energy for Be in the co-implanted samples. This process may have application in improving p-ohmic contact resistance by selective area Be+O implantation. By sharp contrast Mg+O co-implants produced n-type conductivity under all conditions.
Uropathogenic Escherichia coli Metabolite-Dependent Quiescence and Persistence May Explain Antibiotic Tolerance during Urinary Tract Infection (2016)

In the present study, it is shown that although Escherichia coli CFT073, a human uropathogenic (UPEC) strain, grows in liquid glucose M9 minimal medium, it fails to grow on glucose M9 minimal medium agar plates seeded with ≤10(6) CFU. The cells on glucose plates appear to be in a "quiescent" state that can be prevented by various combinations of lysine, methionine, and tyrosine. Moreover, the quiescent state is characteristic of ~80% of E. coli phylogenetic group B2 multilocus sequence type 73 strains, as well as 22.5% of randomly selected UPEC strains isolated from community-acquired urinary tract infections in Denmark. In addition, E. coli CFT073 quiescence is not limited to glucose but occurs on agar plates containing a number of other sugars and acetate as sole carbon sources. It is also shown that a number of E. coli CFT073 mini-Tn5 metabolic mutants (gnd, gdhA, pykF, sdhA, and zwf) are nonquiescent on glucose M9 minimal agar plates and that quiescence requires a complete oxidative tricarboxylic acid (TCA) cycle. In addition, evidence is presented that, although E. coli CFT073 quiescence and persistence in the presence of ampicillin are alike in that both require a complete oxidative TCA cycle and each can be prevented by amino acids, E. coli CFT073 quiescence occurs in the presence or absence of a functional rpoS gene, whereas maximal persistence requires a nonfunctional rpoS. Our results suggest that interventions targeting specific central metabolic pathways may mitigate UPEC infections by interfering with quiescence and persistence. IMPORTANCE Recurrent urinary tract infections (UTIs) affect 10 to 40% of women. In up to 77% of those cases, the recurrent infections are caused by the same uropathogenic E. coli (UPEC) strain that caused the initial infection. Upon infection of urothelial transitional cells in the bladder, UPEC appear to enter a nongrowing quiescent intracellular state that is thought to serve as a reservoir responsible for recurrent UTIs. Here, we report that many UPEC strains enter a quiescent state when ≤10(6) CFU are seeded on glucose M9 minimal medium agar plates and show that mutations in several genes involved in central carbon metabolism prevent quiescence, as well as persistence, possibly identifying metabolic pathways involved in UPEC quiescence and persistence in vivo.
A reliability-aware RF power amplifier design for CMOS radio chip integration (2008)

For significant cost reduction in Wi-Fi platforms, the power amplifier must be integrated into the CMOS radio RFIC. This paper surveys how this most challenging circuit was carefully engineered to mitigate aging effects, ESD, and thermal issues for deployment into our product platforms. Experimental results are also presented here.
Prepubertal chronic stress and ketamine administration to rats as a neurodevelopmental model of schizophrenia symptomatology (2013)

Increased vulnerability to psychiatric disorders, such as schizophrenia, has been associated with higher levels of stress. In the early development of the central nervous system, changes in function of glutamatergic N-Methyl-D-aspartate (NMDA) receptors can possibly result in the development of psychosis, cognitive impairment and emotional dysfunction in adulthood. Thus, in this study we examined the behavioural consequences of the exposure of male rats to chronic stress (postnatal days 30-60) and ketamine administration (postnatal days 41-45); both during a sensitive developmental time window. We found that the locomotor activity of both ketamine and ketamine+chronic stress groups was significantly higher compared with that of the control rats. In contrast, the locomotor activity of the chronic stress group was significantly lower compared with all other groups. Examining anhedonia in the sucrose preference test we found a significantly decreased sucrose intake in both ketamine+chronic stress and the chronic stress groups compared with the control rats. No significant differences were observed in sucrose intake between the control and the ketamine group. The object recognition test revealed that the attention to the novel object was significantly impaired in the ketamine+chronic stress group. Similarly, the ketamine+chronic stress group showed the poorest learning ability in the eight-arm radial maze, starting on the 8th day. Finally, throughout the different pre-pulse intensities, the ketamine+chronic stress group showed impaired PPI compared with all other groups. The results indicate that the combination of prepubertal onset of chronic stress and ketamine may serve as a valid novel animal model for schizophrenia-like symptoms.
Preparation of monodispersed metal particles (1998)

This review article deals with the preparation, characterization and mechanisms of formation of uniform simple and composite metal particles of different modal diameters and shapes. In principle, such dispersions can be obtained by reduction of metal ions, in uncomplexed or complexed state, with suitable reducing agents and appropriate additives. The effect of the redox potential in a given oxidation/reduction system on the nature of the final particles is discussed in some detail. In another approach monodispersed particles of metal compounds are prepared first and then reduced to pure metals either in a liquid or a gaseous medium. In doing so, one can produce powders of a given morphology by selecting the precursor particles of the desired shape. A special case is represented by coated particles, consisting of cores and shells of different chemical composition. Depending on the materials, it is possible to reduce either one or both components by appropriate chemical reactions.
“Kiss-and-Run” Glutamate Secretion in Cultured and Freshly Isolated Rat Hippocampal Astrocytes (2005)

Under physiological conditions, astrocytes not only passively support and nourish adjacent neurons, but also actively modulate neuronal transmission by releasing "glial transmitters," such as glutamate, ATP, and D-serine. Unlike the case for neurons, the mechanisms by which glia release transmitters are essentially unknown. Here, by using electrochemical amperometry and frequency-modulated single-vesicle imaging, we discovered that hippocampal astrocytes exhibit two modes of exocytosis of glutamate in response to various stimuli. After physiological stimulation, a glial vesicle releases a quantal content that is only 10% of that induced by nonphysiological, mechanical stimulation. The small release event arises from a brief (approximately 2 ms) opening of the fusion pore. We conclude that, after physiological stimulation, astrocytes release glutamate via a vesicular "kiss-and-run" mechanism.
Tuning the Dirac Point in CVD-Grown Graphene through Solution Processed n-Type Doping with 2-(2-Methoxyphenyl)-1,3-dimethyl-2,3-dihydro-1<i>H</i>-benzoimidazole (2013)

Controlling the Dirac point of graphene is essential for complementary circuits. Here, we describe the use of 2-(2-methoxyphenyl)-1,3-dimethyl-2,3-dihydro-1H-benzoimidazole (o-MeO-DMBI) as a strong n-type dopant for chemical-vapor-deposition (CVD) grown graphene. The Dirac point of graphene can be tuned significantly by spin-coating o-MeO-DMBI solutions on the graphene sheets at different concentrations. The transport of graphene can be changed from p-type to ambipolar and finally n-type. The electron transfer between o-MeO-DMBI and graphene was additionally confirmed by Raman imaging and photoemission spectroscopy (PES) measurements. Finally, we fabricated a complementary inverter via inkjet printing patterning of o-MeO-DMBI solutions on graphene to demonstrate the potential of o-MeO-DMBI n-type doping on graphene for future applications in electrical devices.