gebhart/patrepeval huggingface dataset:
Single-accelerometer-based daily physical activity classification (2009)

In this study, a single tri-axial accelerometer placed on the waist was used to record the acceleration data for human physical activity classification. The data collection involved 24 subjects performing daily real-life activities in a naturalistic environment without researchers' intervention. For the purpose of assessing customers' daily energy expenditure, walking, running, cycling, driving, and sports were chosen as target activities for classification. This study compared a Bayesian classification with that of a Decision Tree based approach. A Bayes classifier has the advantage to be more extensible, requiring little effort in classifier retraining and software update upon further expansion or modification of the target activities. Principal components analysis was applied to remove the correlation among features and to reduce the feature vector dimension. Experiments using leave-one-subject-out and 10-fold cross validation protocols revealed a classification accuracy of approximately 80%, which was comparable with that obtained by a Decision Tree classifier.
Conditional Random Fields Feature Subset Selection Based on Genetic Algorithms for Phosphorylation Site Prediction (2009)

Conditional random fields (CRFs) are undirected probabilistic graphical models that were introduced for solving sequence labeling and segmenting problems. CRFs have several advantages compared to other well understood and widely used techniques such as hidden Markov models (HMMs) or maximum entropy Markov models (MEMMs). Being a conditional model, it does not explicitly model the input data sequences but uses feature functions (features) to incorporate the arbitrary interactions and inter-dependencies that exist in the observation sequences. The number of all possible features is extremely large, up to millions, and is usually specified and designed in advance or according to a feature-generating scheme based on domain knowledge. This paper introduces a feature subset selection method for CRFs based on genetic algorithms, in which a population of candidate feature function subsets is evolved to achieve a maximal CRF performance. The method was experimentally validated on the well known bioinformatics problem of protein phosphorylation site prediction, phosphorylation being one of the most important protein modification mechanisms.
A Neuroligin-4 Missense Mutation Associated with Autism Impairs Neuroligin-4 Folding and Endoplasmic Reticulum Export (2009)

Neuroligins (NLs) are postsynaptic cell-adhesion molecules essential for normal synapse function. Mutations in neuroligin-4 (NL4) (gene symbol: NLGN4) have been reported in some patients with autism spectrum disorder (ASD) and other neurodevelopmental impairments. However, the low frequency of NL4 mutations and the limited information about the affected patients and the functional consequences of their mutations cast doubt on the causal role of NL4 mutations in these disorders. Here, we describe two brothers with classical ASD who carry a single amino-acid substitution in NL4 (R87W). This substitution was absent from the brothers' asymptomatic parents, suggesting that it arose in the maternal germ line. R87 is conserved in all NL isoforms, and the R87W substitution is not observed in control individuals. At the protein level, the R87W substitution impaired glycosylation processing of NL4 expressed in HEK293 and COS cells, destabilized NL4, caused NL4 retention in the endoplasmic reticulum in non-neuronal cells and neurons, and blocked NL4 transport to the cell surface. As a result, the R87W substitution inactivated the synapse-formation activity of NL4 and abolished the functional effect of NL4 on synapse strength. Viewed together, these observations suggest that a point mutation in NL4 can cause ASD by a loss-of-function mechanism.
Deploying and Running Enterprise Grade Applications in a Federated Cloud (2012)

The notion of cloud computing is a paradigm shift from local machines and networks to virtualization technologies with services as a technical and business concept. This shift introduces major challenges when using cloud for deploying and running enterprise applications in the current Enterprise ecosystems. For companies, picking and choosing the right cloud to meet requirements is hard, and no solution is likely to provide the end-to-end specific IT services delivery and an end-to-end IT solution. Conversely cloud federation assists in providing flexibility to the customer and enables them to lower their TCO by shifting from one cloud to another while mitigating risks associated with a single cloud approach. In order to create competitive differentiation, small businesses require multiple software systems to both meet minimal data management and creative expectations. At the other end of the enterprise ecosystem spectrum, large companies rely on thousands of services in order to meet the needs of everything from simple departmental database applications to core Enterprise Resource planning and Customer Relationship Management systems on which the enterprise itself is managed. As an optimal adoption decision cannot be established for all individual cases, the authors propose to analyze three different use cases for deployment of enterprise applications such as SAP, on the cloud in order to provide some valuable pointers to navigate the emerging cloud ecosystem: rapid provisioning, elasticity and live migration of enterprise applications.
Stabilization of G-Quadruplex DNA by Highly Selective Ligands via Click Chemistry (2006)

A series of G-quadruplex stabilizing compounds have been prepared via click chemistry employing the Cu(I)-catalyzed Huisgen reaction. These compounds were shown to bind tightly to G-quadruplex DNA even in the presence of competing high concentrations of duplex DNA. Furthermore, a modified TRAP assay has shown that some of these compounds also inhibit telomerase at low micromolar concentration.
Sergeants‐and‐Soldiers Principle in Chiral Columnar Stacks of Disc‐Shaped Molecules with <i>C</i><sub>3</sub> Symmetry (1997)

Extremely effective cooperative effects operate during the formation of chiral stacks of C3-symmetrical molecules in alkane solvents (a molecule is depicted on the right). The sergeants-and-soldiers principles as well as chiral solvation lead to a preferred helical sense in the columnar aggregates. The amplification of chirality in dynamic systems shows the precision in aggregation.
On a Data Structure for Adaptive Finite Element Mesh Refinements (1980)

A general labeled tree structure is introduced for a class of nonuniform two-dimensmnal fimte element meshes After defimtmn of the bamc structure, the fundamental access algomthms on the tree are presented m detail. Then the principal algorithms needed for the fimte element computatmns are discussed, including the refinement of the mesh, the computatmn of the elemental stiffness matrices, and the assembly and decomposltmn of the global stiffness matrices based on nested dlssectmn techniques Various possible extensmns of the structure are also given.
Bisphenol A Effects on the Growing Mouse Oocyte Are Influenced by Diet1 (2009)

Growing evidence suggests that exposure to bisphenol A (BPA) has the ability to disrupt several different stages of oocyte development. To date, most attention has focused on the effects of BPA on the periovulatory oocyte, and considerable variation is evident in the results of these studies. In our own laboratory, variation in the results of BPA studies conducted at different times appeared to correlate with changes in mill dates of animal feed. This observation, coupled with reports by others that dietary estrogens in feed are a confounding variable in studies of endocrine-disrupting chemicals, prompted us to evaluate the effect of diet on the results of BPA studies of the periovulatory oocyte. Genetically identical females were placed on a high- or low-phytoestrogen diet prior to mating. Their female offspring were exposed to BPA, oocytes collected, and meiotic spindle and chromosome characteristics compared between control and BPA-treated females. We observed significant diet-related variation in both the frequency of abnormalities in oocytes from untreated females and in the response to BPA. Our results demonstrate that the impact of BPA on meiosis depends, at least in part, on diet. We suggest that variation in the conclusions of recent BPA studies reflects differences in the diets used, as well as other methodological differences. Because meiotic disturbances are a feature of all studies to date, however, we conclude that low levels of BPA adversely affect the meiotic process.
Out of Zone Injection (2018)

Abstract An oil field can be classified as mature when its production rate is significantly declining and/or when it is close to reaching its economic limit. A field might also be considered mature when it is close to attaining a recovery factor considered acceptable for its reservoir mechanisms. Strategies and methodologies to rejuvenate the field, enhancing production and increasing longevity of life will then commence. One of the most common methods of enhancing oil recovery (EOR) is by means of waterflooding, a device whereby injector wells are drilled in an oil field to inject water or gas into the reservoir to increase pressure and stimulate production. This, however, is a complex process posing its own uncertainty in optimally delivering increased production due to the complexity of reservoir type and well design. Having the ability to listen behind casing and deducing flow allocation of injection in which to increase the sweep and improving reservoir production performance becomes vital to enhancing oil recovery. This paper demonstrates how spectral noise logging has aided in rejuvenating oil fields and enhancing oil recovery. Three different oil field examples are examined and discussed, illustrating the methodology and benefits of better understanding flow allocation behind casing to provide much-needed solutions to aid in field life longevity.
Design and implementation of utility-based radio resource optimization using CAPRI (2011)

In this paper we introduce a utility-based optimization approach for wireless communication based on developed Common Application Requirement Interface (CAPRI). The proposed system allows applications to register their utility functions to a radio resource controller at run-time and in automatic way. This enables the implementation of utility-based optimization and run-time reconfiguration of applications. Specifically, in contrast to traditional utility-based optimization approaches that usually aim at optimizing a single application deployed for the entire system, our approach aims to generalize and express the requirements of multiple applications. To validate our proposed system, we have implemented a prototype of CAPRI using Windows platform. The implementation has been made publicly available under an open source license. We show that the overhead induced by the adoption of the CAPRI framework in terms of memory and processing requirements is small, and additional latencies induced by the framework are negligible. Further, a practical case study of multi-application utility-based optimization has been addressed and the results have been analyzed.
Perspective-Driven Radiosity on Graphics Hardware (2011)

Radiosity is a global illumination algorithm used by artists, architects, and engineers for its realistic simulation of lighting. Since the illumination model is global, complexity and run time grow as larger environments are provided. Algorithms exist which generate an incremental result and provide weighting based on the user's view of the environment. This thesis introduces an algorithm for directing and focusing radiosity calculations relative to the user's point-of-view and within the user's field-of-view, generating visually interesting results for a localized area more quickly than a traditional global approach. \n\nThe algorithm, referred to as perspective-driven radiosity, is an extension of the importance-driven radiosity algorithm, which itself is an extension of the progressive refinement radiosity algorithm. The software implemented during research into the point-of-view/field-of-view-driven algorithm can demonstrate both of these algorithms, and can generate results for arbitrary geometry. Parameters can be adjusted by the user to provide results that favor speed or quality. \n\nTo take advantage of the scalability of programmable graphics hardware, the algorithm is implemented as an extension of progressive refinement radiosity on the GPU, using OpenGL and GLSL. Results from each of the three implemented radiosity algorithms are compared using a variety of geometry.
Single Tree Segmentation Using Airborne Laser Scanner Data in a Structurally Heterogeneous Spruce Forest (2006)

In this study, we present a new method for single tree segmentation and characterization from a canopy surface model (CSM), and its corresponding point cloud, based on airborne laser scanning. The method comprises new algorithms for controlling the shape of crown segments, and for residual adjustment of the canopy surface model (CSM). We present a new criterion that measures the success of locating trees, and demonstrate how this criterion can be used for optimizing the degree of CSM smoothing. From the adjusted CSM segments, we derived tree height and crown diameter, and based on all first laser pulse measurements within the segments we derived crown-base height. The method was applied and validated in a Norway spruce dominated forest reserve having a heterogeneous structure. The number of trees automatically detected varied with social status of the trees, from 93 percent of the dominant trees to 19 percent of the suppressed trees. The RMSE values for tree height, crown diameter, and crown-base height were around 1.2 m, 1.1 m, and 3.5 m, respectively. The method overestimated crown diameter (0.8 m) and crown base height (3.0 m).
Design Characteristics of a Three-Dimensional Geometric Aortic Valve Annuloplasty Ring (2013)

A three-dimensional aortic annuloplasty ring was designed that could prove useful for enhancing applicability and stability of aortic valve repair.
A case of silicosis showing multiple pathological lung changes. (1955)

A research paper on the high rate of silicosis and lung diseases in the mining belt of the Copperbelt, Northern Rhodesia (now Zambia) in the 1950's.
Electrocardiographic Indications of Atrial Puncture during Pericardiocentesis (1970)

PERICARDIOCENTESIS with electrocardiographic monitoring, with the use of the technic suggested by Bishop et al.1 of employing the pericardial needle as an exploring electrode, is widely practiced. Elevation of the ST segment indicates that contact of the needle with the ventricular epicardium or myocardium has been made.The purpose of this report is to emphasize the electrocardiographic manifestations of inadvertent puncture of the right atrium during pericardiocentesis.M.M. (S.U.H. 30–40–16), a 47-year-old Japanese woman, underwent catheterization of the right and, retrograde, of the left sides of the heart that confirmed the diagnosis of endocardial-cushion defect. Left ventricular angiography performed through . . .
Microcirculatory Weak Units—An Alternative Explanation (2000)

Department of Anesthesiology, Academic Medical Center, University of Amsterdam, The Netherlands Address requests for reprints to: Can Ince, PhD, Department of Experimental Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 A2 Amsterdam ZO, The Netherlands.
Anatomical and biomechanical characteristics of human meniscofemoral ligaments (1994)

The meniscofemoral ligaments (MFL) of 26 human cadaver knees were studied to determine their structural importance. The incidence of at least one MFL in each of the specimens studied was 100%, and 46% of the specimens had both MFL ligaments (Humphry and Wrisberg). Another 23% had a single Humphry ligament, and the remaining 31% had a single Wrisberg ligament. A laser micrometer system was used to measure cross-sectional shape and area. The average cross-sectional areas of the Humphry and Wrisberg ligaments were 7.8 +/- 4.7 mm2 and 6.7 +/- 4.1 mm2, respectively. In specimens with both a Humphry and Wrisberg ligament, the larger ligament area was on average 100% greater than the smaller ligament area. The average ratios of the cross sectional areas of Wrisberg and Humphry to that for the PCL within the same knee were 12.0% +/- 7.7% and 11.9% +/- 5.7%, respectively. The structural properties of the MFL bone-ligament-meniscus complex and the mechanical properties of the MFL midsubstance were determined by uniaxial tensile testing. The average stiffness, ultimate load, and energy absorbed at failure were, respectively, 49.0 +/- 18.4 N/mm, 297.4 +/- 141.4 N and 1125.4 +/- 735.8 N/mm. The tangent modulus between 4% and 7% strain was 355.1 +/- 234.0 MPa. Our findings suggest that the MFL is a significant biomechanical structure in the knee because of its size, stiffness, and strength.
JASPAR 2010: the greatly expanded open-access database of transcription factor binding profiles (2009)

JASPAR (http://jaspar.genereg.net) is the leading open-access database of matrix profiles describing the DNA-binding patterns of transcription factors (TFs) and other proteins interacting with DNA in a sequence-specific manner. Its fourth major release is the largest expansion of the core database to date: the database now holds 457 non-redundant, curated profiles. The new entries include the first batch of profiles derived from ChIP-seq and ChIP-chip whole-genome binding experiments, and 177 yeast TF binding profiles. The introduction of a yeast division brings the convenience of JASPAR to an active research community. As binding models are refined by newer data, the JASPAR database now uses versioning of matrices: in this release, 12% of the older models were updated to improved versions. Classification of TF families has been improved by adopting a new DNA-binding domain nomenclature. A curated catalog of mammalian TFs is provided, extending the use of the JASPAR profiles to additional TFs belonging to the same structural family. The changes in the database set the system ready for more rapid acquisition of new high-throughput data sources. Additionally, three new special collections provide matrix profile data produced by recent alternative high-throughput approaches.
Application of power electronics to the distribution transformer (2002)

This paper describes the design and prototype construction of a novel solid state transformer. Replacing distribution transformers with solid state devices provides control over the waveshapes and output voltage and can therefore mitigate many power quality problems. A 10 kVA prototype was constructed to transform 7200 V single phase to 240/120 V and has been tested to one-half design voltage.
Crude Oil Prices : Predicting Price Differentials Based on Quality (2004)

Many developing countries are becoming\n oil exporters, producing crude oils that often differ\n markedly in quality from those principally traded.\n Governments must predict the prices of such crudes, to\n forecast revenue and evaluate the fairness of the price they\n receive from companies selling on their behalf. Oil\n companies, and industry consultants, have models for\n analyzing price differentials with well-known\n "marker" crudes, but these models have not been\n widely known, or adapted to account for increasingly\n important quality characteristics, such as acidity. This\n note explains a methodology for price analysis, and a new\n extension for incorporating acidity, which can have a big\n effect on the price differential.
Attention-aware robotic laparoscope for human-robot cooperative surgery (2013)

Current laparoscopic surgeries suffer from inconvenient, limited visualization due to the small incisions. It normally needs an assistant to hold and readjust a laparoscope to view the surgical set when performing procedures. This assistant can be either a human or a robotic laparoscope holder. However, at the current state, both of them only passively follow the control commands from the surgeon (The human assistant relies on the surgeon's verbal communications and the robotic holder is controlled by the voice or joystick/buttons), whenever the laparoscope needs to be readjusted. The surgeon's explicit intervention in laparoscope readjustment might bring extra mental and physical burdens to him/her. In this paper, the work of granting attention-awareness to a robotic laparoscope holder is presented. The robot can actively observe the surgeon's viewing attention by tracking the surgeon's eye movements and automatically adjust the laparoscope's view correspondingly. Our experimental results demonstrated that this system effectively released the surgeon from the intervention of the laparoscope, which could eliminate the visualization barriers of laparoscopic surgeries, reduce the learning curve in laparoscopic surgeries, and reduce the operation time and cost.
Treatment of L5178Y tumor-bearing BDF1 mice with a nonimmunogenic L-glutaminase-L-asparaginase. (1979)

An L-glutaminase-L-asparaginase from Achromobacter has been rendered nonimmunogenic by the covalent attachment of polyethylene glycol (PEG) to nonessential amine groups of the enzyme. PEG-L-glutaminase-L-asparaginase exhibits a greatly enhanced half-life in the bloodstream compared to the unmodified enzyme in normal mice, and is effective in prolonging the survival of BDF1 mice inoculated ip with L5178Y cells. PEG-L-glutaminase-L-asparaginase appears rapidly in the blood following ip injection.
Diels-Alder reactions of 2-pyrones. Direction of the addition reaction with acetylenes (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiels-Alder reactions of 2-pyrones. Direction of the addition reaction with acetylenesJoe A. Reed, Curtis L. Schilling Jr., R. F. Tarvin, Thomas A. Rettig, and John K. StilleCite this: J. Org. Chem. 1969, 34, 7, 2188–2192Publication Date (Print):July 1, 1969Publication History Published online1 May 2002Published inissue 1 July 1969https://pubs.acs.org/doi/10.1021/jo01259a035https://doi.org/10.1021/jo01259a035research-articleACS PublicationsRequest reuse permissionsArticle Views629Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts