gebhart/patrepeval huggingface dataset:
Semi-interpenetrating polymer networks containing polysaccharides. II. Xanthan/lignin networks: a spectral and thermal characterization (2011)

Polysaccharides are important materials in food, pharmaceutical, cosmetic and related biomedical applications. Xanthan gum is a microbial polysaccharide of great commercial significance. Lignin possesses antioxidant, antimicrobial and stabilizer properties. The aim of this study was to investigate by UV-Vis and infrared spectroscopy, wide angle X-ray scattering, differential scanning calorimetry and thermogravimetric studies, the characteristics of biodegradable superabsorbant hydrogels with high swelling rate in aqueous mediums. These were obtained by crosslinking reaction between xanthan gum and different types of lignin (aspen wood lignin, annual fibre crops lignin and lignin epoxy-modified resin) using epichlorhydrine as crosslinking agent. It is expected an increased in thermal stability, hydrophilicity, biocompatibility of hydrogel-films by lignin incorporation. Applications in the food and medical field were also found.
EXPERIMENTS ON THE TENSILE STRENGTH OF THE ANTERIOR CAPSULAR STRUCTURES OF THE SHOULDER IN MAN (1968)

1. A series of experiments on the tensile strength of the anterior capsular mechanism have been performed. These show that in the young the weakest point is the glenoid labral attachment, whereas in the elderly calcification of tissues makes the capsule and subscapular tendon weaker. 2. It has been shown previously that glenoid labral detachment is the common injury in the young at the time of an acute dislocation, whereas capsular rupture and subscapularis tendon damage occur in the elderly. 3. These findings suggest that in an acute anterior dislocation of the shoulder the shoulder integuments give at their weakest point, and that it is the site of this weakest point and not the mechanism of injury which influences the liability to recurrence.
Targeted Cell Fusion Facilitates Stable Heterokaryon Generation In Vitro and In Vivo (2011)

Induced cell fusion has enabled several important discoveries, including the phenomenon of nuclear reprogramming and may yet be applied as a novel therapy for degenerative diseases. However, existing fusogens lack the efficiency required to enable investigation of the epigenetic modifications underlying nuclear reprogramming and the specificity required for clinical application. Here we present a chimeric measles hemagglutinin, Hα7, which specifically and efficiently mediates the fusion of diverse cell types with skeletal muscle both in vitro and in vivo. When compared directly to polyethylene glycol, Hα7 consistently generated a substantial increase in heterokaryon yield and exhibited insignificant levels of toxicity. Moreover, this increased fusion efficiency enabled detection of chromatin modifications associated with nuclear reprogramming following Hα7-mediated fusion of human fibroblasts and mouse myotubes. Finally, Hα7 was also capable of increasing the contribution of transplanted fibroblasts to skeletal muscle repair in vivo, suggesting that this strategy could be used for therapeutic gene delivery.
Trabeculectomy With Mitomycin (1991)

We conducted a prospective, randomized study to compare mitomycin with fluorouracil for efficacy and safety as an adjunct to trabeculectomy in eyes with glaucoma with poor surgical prognosis. Thirty-two eyes of 32 patients were randomly allocated to either mitomycin (17 eyes) or fluorouracil therapy (15 eyes). Mitomycin (0.2 mg) was applied only once during trabeculectomy, and fluorouracil (5 mg) was subconjunctivally injected 10 times in the 2 weeks after surgery. Fifteen eyes (88%) in the mitomycin group and seven (47%) in the fluorouracil group achieved an intraocular pressure of less than or equal to 20 mm Hg without antiglaucoma medication. The follow-up period was 7 to 12 months. Corneal complications were less common in the group given mitomycin than in that given fluorouracil (12% vs 53%). The incidence of other complications was similar between the two groups.
Alkylation of Thiophene with Olefins<sup>1</sup> (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkylation of Thiophene with Olefins1W. G. Appleby, A. F. Sartor, S. H. Lee Jr., and S. W. KapranosCite this: J. Am. Chem. Soc. 1948, 70, 4, 1552–1555Publication Date (Print):April 1, 1948Publication History Published online1 May 2002Published inissue 1 April 1948https://pubs.acs.org/doi/10.1021/ja01184a077https://doi.org/10.1021/ja01184a077research-articleACS PublicationsRequest reuse permissionsArticle Views364Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Latent TGF-β binding protein LTBP-2 decreases fibroblast adhesion to fibronectin (2003)

We have analyzed the effects of latent TGF-beta binding protein 2 (LTBP-2) and its fragments on lung fibroblast adhesion. Quantitative cell adhesion assays indicated that fibroblasts do not adhere to full-length LTBP-2. Interestingly, LTBP-2 had dominant disrupting effects on the morphology of fibroblasts adhering to fibronectin (FN). Fibroblasts plated on LTBP-2 and FN substratum exhibited less adherent morphology and displayed clearly decreased actin stress fibers than cells plated on FN. These cells formed, instead, extensive membrane ruffles. LTBP-2 had no effects on cells adhering to collagen type I. Fibroblasts adhered weakly to the NH2-terminal fragment of LTBP-2. Unlike FN, this fragment did not augment actin stress fiber formation. Interestingly, the adhesion-mediating and cytoskeleton-disrupting effects were localized to the same NH2-terminal proline-rich region of LTBP-2. LTBP-2 and its antiadhesive fragment bound to FN in vitro, and the antiadhesive fragment associated with the extracellular matrix FN fibrils. These observations reveal a potentially important role for LTBP-2 as an antiadhesive matrix component.
Studies on Phenanthrene Derivatives. I (1959)

Pschorr reaction of sodium 3, 4-methylenedioxyphenylacetate or sodium 3, 4-methylenedioxy-6-bromophenylacetate with o-nitrobenzaldehyde afforded 2, 3-or 3, 4-methylenedioxyphenanthrene. The latter had a slightly different melting point from that of a substance assumed to be 3, 4-methylenedioxyphenanthrene, obtained by the Hofmann degradation of anonaine and roemerine, but the picrates of the two substances melted at the same temperature.
Single step lithography for double-recessed gate pseudomorphic high electron mobility transistors (1997)

An asymmetric double-recessed gate process achieved through a single lithography step and a combination of wet and dry etching techniques is presented. The double-recessed gate process is beneficial in the fabrication of InGaAs/AlGaAs/GaAs pseudomorphic high electron mobility transistors (PHEMTs) because breakdown voltage is enhanced while surface effects on the drain side of the gate are minimized. In contrast to conventional processes that require two lithography steps, the current process requires only a single lithography step for the asymmetric placement of a T-gate in a wide recess trench. The process utilizes a four-layer resist of polymethylmethacrylate (PMMA) and P(MMA-MAA) exposed by electron beam lithography. Upon development of the resist, a wet selective etch (citric acid:H2O2) is used to define the wide recess trench and then a dry selective etch (SiCl4/SiF4) is used to recess a narrow trench (within the wide recess trench) in which the gate foot rests. This technique can achieve gate lengths of 0.15μm and drain-side wide recess dimensions from 0.15 to 0.55μm while the source-side recess width is kept at or below 0.15 μm. Device results show improved breakdown voltages and output conductance with only slight reduction in transconductance and drain current for the PHEMTs fabricated using the technique as compared to PHEMTs fabricated using a trilayer T-gate process.
Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRβ/B-RAF (2010)

Kinases are known to regulate fundamental processes in cancer including tumor proliferation, metastasis, neovascularization, and chemoresistance. Accordingly, kinase inhibitors have been a major focus of drug development, and several kinase inhibitors are now approved for various cancer indications. Typically, kinase inhibitors are selected via high-throughput screening using catalytic kinase domains at low ATP concentration, and this process often yields ATP mimetics that lack specificity and/or function poorly in cells where ATP levels are high. Molecules targeting the allosteric site in the inactive kinase conformation (type II inhibitors) provide an alternative for developing selective inhibitors that are physiologically active. By applying a rational design approach using a constrained amino-triazole scaffold predicted to stabilize kinases in the inactive state, we generated a series of selective type II inhibitors of PDGFRbeta and B-RAF, important targets for pericyte recruitment and endothelial cell survival, respectively. These molecules were designed in silico and screened for antivascular activity in both cell-based models and a Tg(fli1-EGFP) zebrafish embryogenesis model. Dual inhibition of PDGFRbeta and B-RAF cellular signaling demonstrated synergistic antiangiogenic activity in both zebrafish and murine models of angiogenesis, and a combination of previously characterized PDGFRbeta and RAF inhibitors validated the synergy. Our lead compound was selected as an orally active molecule with favorable pharmacokinetic properties which demonstrated target inhibition in vivo leading to suppression of murine orthotopic tumors in both the kidney and pancreas.
Reactions of 1,4-Dihydropyridines (1988)

Recent studies o f chemical r e a c t i v i t y of 1.4-dihydropyridines a r e surveyed 1The chemistry o f dihydropyridines (DHP) up t o the year 1980 was treated i n d e t a i l i n .Recently acquired data r e l a t i n g t o the synthesis o f 1.4-dihydropyridines v i a condensation reactions have been sumnarized too2.The present review analyses the chemical r e a c t i v i t y of 1,4-dihydropyridines cover-
A Study of Pharmacokinetic Interaction Between Buspirone and Alprazolam at Steady State (1993)

The steady-state pharmacokinetic interaction between buspirone and alprazolam was evaluated in a parallel study with two groups of 12 male volunteers each. On days 1 to 7, group I subjects received a 1-mg alprazolam tablet every 8 hours (q8h) (TRT 1) and group II subjects received 2 x 5-mg buspirone tablets q8h (TRT 2). On days 8 through 14, all subjects received a combination of 1-mg alprazolam and 2 x 5-mg buspirone tablets q8h (TRT 3). Plasma samples, collected 0 to 8 hours after the morning dose on days 7 and 14, were analyzed for buspirone, alprazolam and their metabolites, 1-PP, and alpha-HO-alprazolam, respectively. Additional samples were collected before the morning dose on days 5 and 6 of each session to monitor the attainment of steady state. Steady-state pharmacokinetic parameters Cmax, Tmax, AUC0-8, and Cmin were calculated. The results indicated that for alprazolam, there was a small (< 10%) increase in Cmax and AUC when coadministered with buspirone. For buspirone, there was a 10% and 29% increase in Cmax and AUC, when coadministered with alprazolam. These values were within the normal variability observed with this class of drugs. Except for a 14% decrease in Cmin for alpha-HO-alprazolam, coadministration of buspirone and alprazolam did not affect the parameters for the metabolites. The results of this study suggest that coadministration of buspirone and alprazolam did not markedly affect the steady-state pharmacokinetics of either drug.
Phosphorylation of Ser <sup>1928</sup> mediates the enhanced activity of the L-type Ca <sup>2+</sup> channel Ca <sub>v</sub> 1.2 by the β <sub>2</sub> -adrenergic receptor in neurons (2017)

The L-type Ca<sup>2+</sup> channel Ca<sub>v</sub>1.2 controls multiple functions throughout the body including heart rate and neuronal excitability. It is a key mediator of fight-or-flight stress responses triggered by a signaling pathway involving β-adrenergic receptors (βARs), cyclic adenosine monophosphate (cAMP), and protein kinase A (PKA). PKA readily phosphorylates Ser<sup>1928</sup> in Ca<sub>v</sub>1.2 in vitro and in vivo, including in rodents and humans. However, S1928A knock-in (KI) mice have normal PKA-mediated L-type channel regulation in the heart, indicating that Ser<sup>1928</sup> is not required for regulation of cardiac Ca<sub>v</sub>1.2 by PKA in this tissue. We report that augmentation of L-type currents by PKA in neurons was absent in S1928A KI mice. Furthermore, S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP), a form of synaptic plasticity that requires Ca<sub>v</sub>1.2 and enhancement of its activity by the β<sub>2</sub>-adrenergic receptor (β<sub>2</sub>AR)-cAMP-PKA cascade. Thus, there is an unexpected dichotomy in the control of Ca<sub>v</sub>1.2 by PKA in cardiomyocytes and hippocampal neurons.
Animal experiments for the evaluation of laserspectroscopy in the fetus during labor (1991)

Laserspectroscopy with near-infrared light is newly available for clinical application. The equipment consists of a near-infrared data collection unit (NIRDCU) and a personal computer. Emission of laser light at wavelengths of 775, 805, 845 and 904 nm is provided by the four laser diodes of the NIRDCU. By analyzing changes of optical density during laser radiation, information is obtained regarding the intracellular redox state and relative changes of blood volume. During measurement with the system on the fetal scalp during delivery we were able to get a first impression of the method's potential. While the application of the laser sensors is still cumbersome, signals providing information of the relative changes of hemoglobin concentration, relative changes of blood volume and cytochrome aa3 seems achievable. Laserspectrophotometric monitors may become safe, low cost and portable instruments for the non-invasive assessment of the biochemical and biophysical status in the fetus.
Periodic mesoporous organosilica mesophases are versatile precursors for the direct preparation of mesoporous silica/carbon composites, carbon and silicon carbide materials (2006)

We report the direct preparation of mesoporous silica/carbon composites, mesoporous silica, and nanostructured carbon and silicon carbide materials from mesoporous ethyl-bridged organosilica/surfactant mesophases. Well ordered mesoporous silica/carbon composites, with surface area of ca. 820 m2 g−1 and pore volume of 0.4 cm3 g−1, were obtained via pyrolysis of organosilica mesophases under argon flow at between 800–950 °C. Higher pyrolysis temperature (1100 °C) generated composites with lower porosity. Well ordered mesoporous or super-microporous silicas (with surface area >700 m2 g−1 and pore volume >0.35 cm3 g−1) were readily obtained from calcination (at 550 °C for 8 h in static air) of the silica/carbon composites, while porous carbons (surface area >500 m2 g−1 and pore volume >0.3 cm3 g−1) were generated via silica etching of the composites. The mesoporous silica/carbon composites, mesoporous silica and mesoporous carbon materials retained the particle morphology of the organosilica mesophases. Furthermore, nanostructured and highly crystalline silicon carbide materials with high surface area (380–620 m2 g−1) and pore volume (0.35–0.9 cm3 g−1) were also prepared via pyrolysis of the ethyl-bridged organosilica/surfactant mesophases at suitably high (1300–1350 °C) temperatures followed by calcination in air and silica etching.
WASP: A System and Algorithms for Accurate Radio Localization Using Low-Cost Hardware (2010)

In this paper, we present a low-cost wireless sensor network platform, called wireless ad hoc system for positioning (WASP), that has been developed for high-accuracy localization and tracking. This platform uses the time of arrival (TOA) of beacon signals periodically transmitted by the nodes at known times for localization. The system was designed to have a unique tradeoff between hardware complexity and processing complexity to provide high accuracy at minimal cost in complex radio propagation environments. To enable the system to perform well in realistic environments, it was also necessary to develop novel extensions to existing algorithms for the measurement of TOA, localization, and tracking. In this paper, we describe the architecture, hardware, and algorithms of WASP and present results based on field trials conducted in different radio propagation environments. The results show that WASP achieves a ranging accuracy of 0.15 m outdoors and 0.5 m indoors when around 12 anchor nodes are used. These accuracies are achieved with operating range of up to 200 m outdoors and 30 m indoors. This compares favorably to other published results for systems operating in realistic environments.
A Transmembrane Segment Mimic Derived from Escherichia coli Diacylglycerol Kinase Inhibits Protein Activity (2003)

The function of membrane proteins is inextricably linked to the proper packing and assembly of their independently helical transmembrane (TM) segments. Here we examined whether an externally added TM peptide analogue could specifically inhibit the function of the membrane protein from which it is derived by competing for native TM helix packing sites, thereby producing a non-functional peptide-protein complex. This hypothesis was tested using Lys-tagged peptides synthesized with sequences corresponding to the three TM segments of the homotrimeric Escherichia coli diacylglycerol kinase (DGK). The peptide corresponding to wild-type DGK TM-2 inhibited the protein's enzymatic activity in a dose-dependent manner through formation of an inactive pseudo-complex, whereas peptides derived from TM-1 and TM-3 were benign toward DGK structure/function. Also, substitution of a conserved residue (Glu-69) within the TM-2 peptide abolished these effects, demonstrating the strict sequence requirements for TM-2-mediated association. This strategy, coupled with the practical advantages of the water solubility of Lys-tagged TM peptides, may constitute an attractive approach for the design of therapeutic membrane protein modulators even in the absence of a high resolution structure.
Modulation of Proteasomal Activity Required for the Generation of a Cytotoxic T Lymphocyte–defined Peptide Derived from the Tumor Antigen MAGE-3 (1999)

We have analyzed the presentation of human histocompatability leukocyte antigen-A*0201-associated tumor peptide antigen MAGE-3271-279 by melanoma cells. We show that specific cytotoxic T lymphocyte (CTL)-recognizing cells transfected with a minigene encoding the preprocessed fragment MAGE-3271-279 failed to recognize cells expressing the full length MAGE-3 protein. Digestion of synthetic peptides extended at the NH2 or COOH terminus of MAGE-3271-279 with purified human proteasome revealed that the generation of the COOH terminus of the antigenic peptide was impaired. Surprisingly, addition of lactacystin to purified proteasome, though partially inhibitory, resulted in the generation of the antigenic peptide. Furthermore, treatment of melanoma cells expressing the MAGE-3 protein with lactacystin resulted in efficient lysis by MAGE-3271-279-specific CTL. We therefore postulate that the generation of antigenic peptides by the proteasome in cells can be modulated by the selective inhibition of certain of its enzymaticactivities.
A Novel Dual-Antenna Structure for UHF RFID Tags (2011)

A novel dual-antenna tag structure for UHF radio-frequency identification (RFID) systems is proposed. It is formed by two linearly tapered meander dipole antennas that are perpendicular to each other and connected to the slightly modified tag chip. One of the antennas is for receiving, while the other is for backscattering. The input impedance of the receiving antenna is designed to be conjugate matched to the highly capacitive chip impedance for the maximum power transfer. Meanwhile, the backscattering antenna is alternatively terminated by an open or a short circuit to modulate the backscattered field. By making the input impedance of the backscattering antenna real-valued, the maximum differential RCS may be achieved leading to a longer read range and better reliability. With the aid of the design of experiments (DOE) technique, the proposed dual-antenna structure is designed to fit within a compact area of 32.8 × 32.8 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> while keeping relatively low mutual coupling between the two antennas. The impedance, receiving, and backscattering performances of the proposed dual-antenna structure are measured and simulated, and they agree very well. Also, it is demonstrated that the proposed dual-antenna structure outperforms the conventional single-antenna tag design in every respect.
Perceptual Reinforcement of Speech Signal Based on Partial Specific Loudness (2007)

In the presence of background noise, the perceptual loudness of speech signal significantly decreases, resulting in the deterioration of intelligibility and clarity. In this letter, we propose a novel approach to enhance the perceived quality of the speech signal when the additive noise cannot be directly controlled. Instead of controlling the background noise, we propose to reinforce the speech signal so that it can be heard more clearly in noisy environments. To find a suitable reinforcement rule, the loudness perception model proposed by Moore et al. is adopted. Experimental results show that the loudness of the reinforced signal can be maintained at the level almost the same as that of the original noise-free speech, and the proposed algorithm can enhance the perceived speech quality under various noise environments.