gebhart/patrepeval huggingface dataset:
Studies on the Reactivity of Dicyanodihydroborate with Some Lewis Base Hydrochlorides (1990)

Abstract The reactions of sodium dicyanodihydroborate with various Lewis base hydrochlorides produce mainly the metathesis reaction products in contrast to those of sodium cyanotrihydroborate, which produces cyanoborane adducts. This has been established with the help of IR, 1H and 11B NMR data.
History of the ketogenic diet (2008)

Fasting and other dietary regimens have been used to treat epilepsy since at least 500 BC. To mimic the metabolism of fasting, the ketogenic diet (KD) was introduced by modern physicians as a treatment for epilepsy in the 1920s. For two decades this therapy was widely used, but with the modern era of antiepileptic drug treatment its use declined dramatically. By the end of the twentieth century this therapy was available in only a small number of children's hospitals. Over the past 15 years, there has been an explosion in the use, and scientific interest in the KD. This review traces the history of one of the most effective treatments for childhood epilepsy.
Chronic Multisymptom Illness Affecting Air Force Veterans of the Gulf War (1998)

Among currently active members of 4 Air Force populations, a chronic multisymptom condition was significantly associated with deployment to the GW. The condition was not associated with specific GW exposures and also affected nondeployed personnel.
Channel Equalization in Fast-Convolution Filter Bank based Receivers for Professional Mobile Radio (2014)

Fast convolution processing has recently been pro- posed as an efficient approach for implementing filter bank multicarrier systems with good spectral containment and high flexibility in adjusting the subchannel bandwidths and center frequencies. These features make fast convolution filter banks (FC-FBs) a particularly interesting choice for multicarrier trans- mission in challenging radio scenarios like dynamic spectrum access, cognitive radio, and fragmented spectrum use. In this contribution, the target is to compare the performance of the time-domain equalizer with the frequency-domain equalizer implemented through subcarrier processing in LTE-like multi- carrier systems. It is shown that integrating the equalization functions with the FC-FB processing leads to an efficient overall implementation in terms of performance and computational complexity.
Ultrasensitive aptamer biosensor for arsenic(iii) detection in aqueous solution based on surfactant-induced aggregation of gold nanoparticles (2012)

This paper reports the colorimetric and resonance scattering (RS)-based biosensor for the ultrasensitive detection of As(III) in aqueous solution via aggregating gold nanoparticles (AuNPs) by the special interactions between arsenic-binding aptamer, target and cationic surfactant. Aptamers and the cationic surfactant could assemble to form a supramolecule, which prevented AuNPs from aggregating due to the exhaustion of cationic surfactant. The introduction of As(III) specifically interacted with the arsenic-binding aptamer to form the aptamer-As(III) complex, so that the following cationic surfactant could aggregate AuNPs and cause the remarkable change in color and RS intensity. The results of circular dichroism (CD) and scanning probe microscope (SPM) testified to the formation of the supramolecule and aptamer-As(III) complex, and the observation of transmission electron microscope (TEM) further confirmed that the aggregation of AuNPs could be controlled by the interactions among the aptamer, As(III) and cationic surfactant. The variations of absorbance and RS intensity were exponentially related to the concentration of As(III) in the range from 1 to 1500 ppb, with the detection limit of 40 ppb for the naked eye, 0.6 ppb for colorimetric assay and 0.77 ppb for RS assay. Additionally, the speed of the present biosensor was rapid, and it also exhibited high selectivity over other metal ions with an excellent recovery for detection in real water samples, suggesting that the proposed biosensor will play an important role in environmental detection.
An Introduction to IMS: Your Complete Guide to IBM Information Management System (2011)

IBMs Definitive One-Stop Guide to IMS Versions 12, 11, and 10: for Every IMS DBA, Developer, and System Programmer Over 90% of the top Fortune 1000 companies rely on IBMs Information Management System (IMS) for their most critical IBM System z data management needs: 50,000,000,000+ transactions run through IMS databases every day. Whats more, IBM continues to upgrade IMS: Versions 12, 11, and 10 meet todays business challenges more flexibly and at a lower cost than ever before. In An Introduction to IMS, Second Edition, leading IBM experts present the definitive technical introduction to these versions of IMS. More than a complete tutorial, this book provides up-to-date examples, cases, problems, solutions, and a complete glossary of IMS terminology. Prerequisite reading for the current IBM IMS Mastery Certification Program, it reflects major recent enhancements such as dynamic information generation; new access, interoperability and development tools; improved SOA support; and much more. Whether youre a DBA, database developer, or system programmer, it brings together all the knowledge youll need to succeed with IMS in todays mission critical environments. Coverage includes What IMS is, how it works, how it has evolved, and how it fits into modern enterprise IT architecturesProviding secure access to IMS via IMS-managed application programsUnderstanding how IMS and z/OS work together to use hardware and software more efficientlySetting up, running, and maintaining IMSRunning IMS Database Manager: using the IMS Hierarchical Database Model, sharing data, and reorganizing databasesUnderstanding, utilizing, and optimizing IMS Transaction ManagerIMS application development: application programming for the IMS Database and IMS Transaction Managers, editing and formatting messages, and programming applications in JavaIMS system administration: the IMS system definition process, customizing IMS, security, logging, IMS operations, database and system recovery, and moreIMS in Parallel Sysplex environments: ensuring high availability, providing adequate capacity, and balancing workloads
Liquid crystalline side group polyesters with a systematic variation of main chain and side group spacer length (1999)

To investigate the influence of a systematic variation of the length of main chain and side group spacers on the thermal phase behaviour four homologous series of liquid crystalline side group polyesters with 4-(phenylazo)azobenzene moieties as mesogenic side groups have been prepared and characterized. The polyesters exhibit smectic and/or nematic phases. The mesomorphic properties were studied by using optical polarizing microscopy, differential scanning calorimetry (DSC) and X-ray diffraction. Packing models of the low ordered smectic phases have been derived from X-ray data.
Evaluation of Microvalves Developed for Point-of-Care Testing Devices Using Shape-Memory Polymers (2013)

A temporal change in temperature in an actuating shape-memory polymer (SMP) valve has been measured by analyzing the fluorescence spectrum of sulforhodamine B in the aqueous solution. The SMP microvalve used in this study was recently developed by the authors. It is actuated by the shape recovery of poly(ε-caprolactone) (PCL), which is triggered by heat from a microheater. To obtain information about temperature rise during operation, we measured “temperature quenching” of the fluorescence from sulforhodamine B using laser-induced fluorescence (LIF) spectroscopy. The maximum temperature during valve actuation was approximately 60 °C and was slightly higher than the phase transition temperature 52 °C of the PCL material used in this study. The results indicate that the present microvalve is potentially applicable to practical point-of-care testing devices.
Segmentation Based Sparse Reconstruction of Optical Coherence Tomography Images (2016)

We demonstrate the usefulness of utilizing a segmentation step for improving the performance of sparsity based image reconstruction algorithms. In specific, we will focus on retinal optical coherence tomography (OCT) reconstruction and propose a novel segmentation based reconstruction framework with sparse representation, termed segmentation based sparse reconstruction (SSR). The SSR method uses automatically segmented retinal layer information to construct layer-specific structural dictionaries. In addition, the SSR method efficiently exploits patch similarities within each segmented layer to enhance the reconstruction performance. Our experimental results on clinical-grade retinal OCT images demonstrate the effectiveness and efficiency of the proposed SSR method for both denoising and interpolation of OCT images.
High-Level Biosynthesis of the Anteiso-C <sub>17</sub> Isoform of the Antibiotic Mycosubtilin in <i>Bacillus subtilis</i> and Characterization of Its Candidacidal Activity (2009)

High-level production (880 mg liter(-1)) and isolation of the anteiso-C(17) isoform of the lipopeptide mycosubtilin produced by a genetically engineered Bacillus subtilis strain are reported. Antifungal activity of this isoform, as determined via culture and fluorometric and cell leakage assays, suggests its potential therapeutic use as an antifungal agent, in particular against Candida spp.
Linear induction motors as ‘electromagnetic rivers’ (1974)

Conducting material, in both the solid and the liquid state, can be suspended above a.c. coil systems. It is shown how a rectangular plate, suspended by one such system, may also be propelled by the same system of currents which serve to suspend it, and that lateral guidance is then automatically built into the system. In early experiments which are described, over 90% of the input power to such a system was converted into heat in the process of suspension and guidance. Further inventions are then described, by means of which it is theoretically possible to convert the whole ofthe secondary input power to propulsion. It is concluded that such systems show promise for application to high-speed ground transport.
Microsoft universal data access platform (1998)

Microsoft Universal Data Access defines a platform for developing multi-tier enterprise applications that require efficient access to diverse relational or non-relational data sources across intranets or the Internet. Universal Data Access consists of a collection of software components that interact with each other using system-level interfaces defined by OLE DB and providing an application-level data access model called ActiveX Data Objects (ADO). This talk provides an overview of the platform.
Discovery of a Potent, Orally Active, Nonsteroidal Androgen Receptor Agonist:  4-Ethyl-1,2,3,4-tetrahydro-6- (trifluoromethyl)-8-pyridono[5,6-<i>g</i>]- quinoline (LG121071) (1999)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTDiscovery of a Potent, Orally Active, Nonsteroidal Androgen Receptor Agonist: 4-Ethyl-1,2,3,4-tetrahydro-6- (trifluoromethyl)-8-pyridono[5,6-g]- quinoline (LG121071)Lawrence G. Hamann, Neelakandha S. Mani, Robert L. Davis, Xiao-Ning Wang, Keith B. Marschke, and Todd K. JonesView Author Information Departments of Medicinal Chemistry, Endocrine Research, and New Leads Discovery, Ligand Pharmaceuticals, Inc., 10275 Science Center Drive, San Diego, California 92121. Cite this: J. Med. Chem. 1999, 42, 2, 210–212Publication Date (Web):January 8, 1999Publication History Received24 November 1998Published online8 January 1999Published inissue 1 January 1999https://doi.org/10.1021/jm9806648Copyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1174Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (62 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Agonists,Antagonists,Assays,Quinolines,Receptors Get e-Alerts
NAP Protects against Tau Hyperphosphorylation Through GSK3 (2018)

These results together with the previous findings strongly corroborated Tau's involvement in NAP/ADNP cellular activity.
ABCA1 redistributes membrane cholesterol independent of apolipoprotein interactions (2003)

ATP binding cassette transporter A1 (ABCA1) mediates the transport of phospholipids and cholesterol from cells to lipid-poor HDL apolipoproteins. Cholesterol loading of cells induces ABCA1, implicating cholesterol as its major physiologic substrate. It is believed, however, that ABCA1 is primarily a phospholipid transporter and that cholesterol efflux occurs by diffusion to ABCA1-generated phospholipid-rich apolipoproteins. Here we show that overexpression of ABCA1 in baby hamster kidney cells in the absence of apolipoproteins redistributed membrane cholesterol to cell-surface domains accessible to treatment with the enzyme cholesterol oxidase. The cholesterol removed by apolipoprotein A-I (apoA-I), but not by HDL phospholipids, was derived exclusively from these domains. ABCA1 overexpression also increased cholesterol esterification, which was prevented by addition of apoA-I, suggesting that some of the cell-surface cholesterol not removed by apolipoproteins is transported to the intracellular esterifying enzyme acyl-CoA:cholesterol acyltransferase. ABCA1 expression was essential for cholesterol efflux even when apolipoproteins had already acquired phospholipids during prior exposure to ABCA1-expressing cells. These studies show that ABCA1 redistributes cholesterol to cell-surface domains, where it becomes accessible for removal by apolipoproteins, consistent with a direct role of ABCA1 in cholesterol transport.
The Development and Spread of Some Virus Diseases of Grapevines in California Vineyards (1954)

The symptoms, distribution, and importance of Fanleaf and Yellow Mosaic, two virus diseases of grapevines, are given. Evidence of strains of yellow mosaic and retention of the virus in the soil is also presented.
Clinical Features, Pathogenesis, and Treatment of Large Granular Lymphocyte Leukemias (2017)

Large granular lymphocytes (LGLs) are large lymphocytes with azurophilic granules in their cytoplasm. LGLs are either natural killer (NK) cells or T lymphocytes. Expansions of the LGLs in the peripheral blood are seen in various conditions, including three clonal disorders: T-cell LGL (T-LGL) leukemia, chronic lymphoproliferative disorders of NK cells (CLPD-NK), and aggressive NK-cell leukemia (ANKL). However, the monoclonal and polyclonal expansion of LGLs has been associated with many other conditions. The present article describes these LGL disorders, with special emphasis on the clinical features, pathogenesis, and treatments of the three above-mentioned clonal disorders.
DEMO: SDN-based network slicing in C-RAN (2018)

Network slicing is considered a key technology for the upcoming 5G system, enabling operators to efficiently support multiple services with heterogeneous requirements, over a common shared infrastructure. In this demo, we present a prototype for managing network slices in the Cloud Radio Access Network (C-RAN), which is considered the reference network architecture for 5G. Our prototype deals with the spectrum slicing problematic and aims at efficiently sharing the bandwidth resources among different slices, while considering their requirements. The prototype makes use of the Open Air Interface (OAI) platform and a specific Software Defined Network (SDN) controller, known as FlexRAN. By using real smart-phones, we run experiments on stage to validate the feasibility of the prototype in configuring multiple slices on-demand, driven by the input of a northbound application.
A simple three-terminal IC bandgap reference (1974)

A new configuration for realization of a stabilized bandgap voltage is described. The new two-transistor circuit uses collector current sensing to eliminate errors due to base current. Because the stabilized voltage appears at a high impedance point, the application to circuits with higher output voltage is simplified. Incorporation of the new two-transistor cell in a three-terminal 2.5-V monolithic reference is described. The complete circuit is outlined in functional detail together with analytical methods used in the design. The analytical results include sensitivity coefficients, gain and frequency response parameters, and biasing for optimum temperature performance. The performance of the monolithic circuit, which includes temperature coefficients of 5 ppm//spl deg/C over the military temperature range, is reported.
Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells. (1995)

Dihydropyridine-sensitive voltage-dependent calcium channels (VDCC) play a crucial role in insulin secretion. We recently have cloned a human alpha 1-subunit of the VDCC expressed in pancreatic beta-cells, designated CACN4. In this study we have isolated complementary DNAs encoding two forms of rat CACN4 (rCACN4A and rCACN4B) from a rat insulinoma RINm5F complementary DNA library. Rat CACN4A is a protein of 2203 amino acids and is the rat homolog of human CACN4, whereas rCACN4B lacks 535 amino acids in the carboxyl-terminal region, probably due to alternative splicing. We have found two additional variations, one in the intracellular loop between repeats I and II and the other in the extracellular region between the third and fourth segments of repeat IV. Reverse transcriptase-polymerase chain reaction analysis of rat pancreatic islet messenger RNA reveals that these variants are present in pancreatic islets. In addition, whole-cell voltage-clamp recordings of Chinese hamster ovary cells stably expressing the alpha 1-subunit (rCACN4A or rCACN4B) with or without the calcium channel beta 2-subunit show that coexpression of rCACN4A with the beta 2-subunit or rCACN4B with the beta 2-subunit elicits L-type VDCC currents, whereas expression of the alpha 1-subunit alone does not, indicating that CACN4 can associate functionally with the beta 2-subunit and that the beta-subunit is essential for functional expression of CACN4. These results suggest that there are various subtypes of CACN4 expressed in pancreatic beta-cells, and that both rCACN4A and rCACN4B can function as VDCC. Furthermore, the present study suggests that the expression of the beta-subunit as well as the alpha 1-subunit may participate in the regulation of insulin secretion.
Relief of cholestatic pruritus by a novel class of drugs: 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists: effectiveness of ondansetron (1995)

The objective of the present study was to determine whether ondansetron, a specific serotonin type 3 receptor antagonist (5-HT3), relieves cholestatic pruritus in patients resistant to conventional antipruritic therapy (antihistamines and cholestyramine). In a placebo-controlled study the acute effect of an intravenous injection of ondansetron (4 mg, 8 mg) or placebo (NaCl solution) was tested in 10 patients (41-66 years of age; 4 men, 6 women) with cholestatic itch. A successful treatment was assessed when the intensity of itch was reduced by 50% or more within 2 h after injection of ondansetron. Intensity of itch was determined by the patients on a visual rating scale from 0 to 10. Ondansetron reduced or abolished pruritus within 30-60 min after injection. A 50% reduction of the intensity of itch was observed up to 6 h after injection of 8 mg. The effect was reproducible in the same patient. In conclusion ondansetron is effective in the treatment of cholestatic itch. Serotonin may participate in the generation and/or sensation of cholestatic pruritus.
Sonochemical Treatment of Wastewater Effluent for the Removal of Pathogenic Protozoa Exemplified by <i>Cryptosporidium</i> (2007)

To meet the increasing demand for potable water, reuse and reclamation projects must be developed and implemented to augment water sources. The reuse of treated wastewater could provide a significant portion of the demand for clean water. Although there are many issues concerning the quality and safety of wastewater before it can be reused, the major technical concerns are how to deal with microbial and chemical contamination. Pathogenic organisms such as Cryptosporidium and Giardia pose a potential threat to public health. Cryptosporidium parvum oocysts can withstand many typical disinfection processes, particularly chlorine-based systems. Typically, the chlorine dose can be increased to eliminate the pathogens, but there is a trade-off in treatment strategies. Eliminating the biological contaminants with large doses of chlorine brings about the disinfectant by-product (DBP) problem, while minimizing the DBP formation requires reduced rates of chlorine, leading to a larger population of potentially dangerous microorganisms, e.g., Cryptosporidium and Giardia. The goal of this research was to assess ultrasonic technology for the treatment of wastewaters for possible reuse. As ultrasonic waves travel through a liquid medium, hydroxyl radicals/are produced (OH∙). OH∙ is a powerful oxidation agent that can react with a wide spectrum of soluble organic chemicals and can also render bacteria and protozoan pathogens inactive. Additionally, the extreme temperatures and pressures, along with the shock wave caused during cavitation bubble collapse, can exert great forces on the pathogens and cause impairment. Various factors that may affect the efficiency of the inactivation of Cryptosporidium such as initial microbial density, pH, temperature, and energy intensity were assessed. It was demonstrated that the ultrasonic process is an effective disinfection technology.
The FAIR Guiding Principles for scientific data management and stewardship (2016)

There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse set of stakeholders-representing academia, industry, funding agencies, and scholarly publishers-have come together to design and jointly endorse a concise and measureable set of principles that we refer to as the FAIR Data Principles. The intent is that these may act as a guideline for those wishing to enhance the reusability of their data holdings. Distinct from peer initiatives that focus on the human scholar, the FAIR Principles put specific emphasis on enhancing the ability of machines to automatically find and use the data, in addition to supporting its reuse by individuals. This Comment is the first formal publication of the FAIR Principles, and includes the rationale behind them, and some exemplar implementations in the community.