gebhart/patrepeval huggingface dataset:
Programming with VisualAge for Java (1998)

Note: Includes glossary and index Reference Record created on 2004-09-07, modified on 2011-09-01
Optimal rate allocation in kinematically-redundant manipulators-the dual projection method (2002)

A coordination algorithm for optimal solution of the rate allocation problem in kinematically redundant manipulators is presented. This solution follows from exploring the projection properties of orthogonal surfaces characterized by the velocity kinematics of the redundant system. It is shown that, using the dual projection theorems between the row and the null spaces to be derived, a commonly used, general solution can be reformulated into a computationally efficient form. This method, known as the dual projection method, offers an equivalent but more efficient alternative to the conventional pseudo-inverse based, gradient projection technique, and is applicable to any linear systems with redundancy. To demonstrate its effectiveness, an analytic example using a spatial manipulator with one degree of redundancy is presented. Discussions of computational efficiency based on numbers of arithmetic operations are included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A preliminary screening and characterization of suitable acids for sandstone matrix acidizing technique: a comprehensive review (2018)

Matrix acidizing is a broadly developed technique in sandstone stimulation to improve the permeability and porosity of a bottom-hole well. The most popular acid used is mud acid (HF–HCl). It is a mixture of hydrofluoric acid and hydrochloric acid. However, one of the conventional problems in sandstone acidizing is that mud acid faces significant issues at high temperature such as rapid rate of reaction, resulting in early acid consumption. This downside has given a negative impact to sandstone acidizing as it will result in not only permeability reduction, but can even extend to acid treatment failure. So, the aim of this study is to provide a preliminary screening and comparison of different acids based on the literature to optimize the acid selection, and targeting various temperatures of sandstone environment. This paper has comprehensively reviewed the experimental works using different acids to understand the chemical reactions and transport properties of acid in sandstone environment. The results obtained indicated that fluoroboric acid (HBF4) could be useful in enhancing the sandstone acidizing process, although more studies are still required to consolidate this conclusion. HBF4 is well known as a low damaging acid for sandstone acidizing due to its slow hydrolytic reaction to produce HF. This would allow deeper penetration of the acid into the sandstone formation at a slower rate, resulting in higher porosity and permeability enhancement. Nevertheless, little is known about the effective temperature working range for a successful treatment. Considering the pros and cons of different acids, particularly those which are associated with HF and HBF4, it is recommended to perform a comprehensive analysis to determine the optimum temperature range and effective working window for sandstone acidizing before treatment operation. Prior to sandstone acid stimulation, it is essential to predict the feasibility of acid selected by integrating the effects of temperature, acid concentration and injection rate. Therefore, this manuscript has thrown light into the research significance of further studies.
Mechanisms of ester hydrolysis in aqueous sulfuric acids (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanisms of ester hydrolysis in aqueous sulfuric acidsKeith. Yates and Robert A. McClellandCite this: J. Am. Chem. Soc. 1967, 89, 11, 2686–2692Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 May 1967https://pubs.acs.org/doi/10.1021/ja00987a033https://doi.org/10.1021/ja00987a033research-articleACS PublicationsRequest reuse permissionsArticle Views2514Altmetric-Citations90LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Utilization of Unused Energy. (1993)

未利用エネルギーとしてごみ焼却熱, 工場廃熱, その他の廃熱, 河川水, 海水, 下水をとりあげている。これらをどのように活用できるかについて一般論を述べ, 量的にどれ位期待できるかを近畿地域を例にとって示しでいる。そしてそれぞれの未利用エネルギーがどのように活用されているかを代表的な事例をあげ, 具体的に説明している。最後に未利用エネルギーを活用する上での課題について述べている。
Experimental results of a controllable electrostatic/gecko-like adhesive on space materials (2014)

Many space applications, such as docking, satellite capture, or robotic inspection, could benefit from the use of a controllable (i.e. on-off) adhesive capable of functioning on a wide range of surfaces. This paper focuses on the experimental results of such an adhesive, which combines the benefits of both electrostatic and directional dry adhesives (i.e. gecko-like adhesives). The electrostatic element consists of a conductive electrode pattern embedded inside a soft silicone polymer dielectric. Between the electrodes and the substrate lies a dry adhesive element comprised of directional fibrillar structures. The combination of these two technologies creates a positive feedback cycle in which, depending on surface roughness and material, adhesive levels can be greater than the sum of the two individual technologies. The electrostatic adhesive serves to initially engage the micro-wedges with the surface substrate. As they engage, the micro-wedges bring the electrostatic element closer to the surface, which further increases its adhesion. This consequently allows more of the dry adhesive micro-wedges to engage, particularly on rough surfaces. This paper presents the results of experimental testing of these adhesives over a range of different space-grade materials. These include different paints, composites, and blankets. Results show that the hybrid adhesive performs up to 7.1× greater than electrostatic adhesives alone.
Immunologic and Genetic Relationship between Herpes Simplex Virus and Bovine Herpes Mammillitis Virus (1973)

Herpes simplex virus types land 2 specific immune sera, sera from convalescent and healthy humans, and bovine herpes mammillitis virus-specific hyperimmune sera showed cross-neutralization with the heterologous viruses. The antigenic relationship of these herpes viruses was confirmed with complement fixation, immunodiffusion and immunofluorescence tests. Bovine herpes mammillitis infection of test animals protected them against a fatal herpes simplex virus infection. The DNA of the bovine herpes mammillitis virus (63% guanadine + cytosine; G + C) shared about 14% base sequence homology with that of herpes simplex virus type 1 (66% G + C), whereas the genetic relatedness with the infectious bovine rhinotracheitis and pseudorabies virus was less than 8%.
Fibronectin binds to the C1q component of complement. (1982)

Fibronectin immobilized to plastic tubes binds soluble C1q with a Kd of 82 +/- 2.6 nM. The binding of fibronectin to C1q is relatively insensitive to pH but is sensitive to ionic conditions. C1q covalently bound to Sepharose selectively binds cellular fibronectin produced by a hamster fibroblast cell line. The globular head regions of C1q have no effect on the binding of C1q to fibronectin but the collagenous tails of C1q interfere competitively with a Ki of 59 nM. We conclude that fibronectin binds C1q via its collagen-like tail region and thus the process resembles the binding of fibronectin to gelatin. This is further emphasized by our observation that gelatin binds to fibronectin immobilized on plastic tubes with a Kd of 131 nM. Because fibronectin stimulates endocytosis in several systems and promotes the clearance of particulate material from the circulation, these results suggest the possibility that fibronectin could function in the clearance of C1q-coated material such as immune complexes or cellular debris.
Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes. (1995)

To investigate the genetic component of multifactorial diseases such as type 1 (insulin-dependent) diabetes mellitus (IDDM), models involving the joint action of several disease loci are important. These models can give increased power to detect an effect and a greater understanding of etiological mechanisms. Here, we present an extension of the maximum lod score method of N. Risch, which allows the simultaneous detection and modeling of two unlinked disease loci. Genetic constraints on the identical-by-descent sharing probabilities, analogous to the "triangle" restrictions in the single-locus method, are derived, and the size and power of the test statistics are investigated. The method is applied to affected-sib-pair data, and the joint effects of IDDM1 (HLA) and IDDM2 (the INS VNTR) and of IDDM1 and IDDM4 (FGF3-linked) are assessed with relation to the development of IDDM. In the presence of genetic heterogeneity, there is seen to be a significant advantage in analyzing more than one locus simultaneously. Analysis of these families indicates that the effects at IDDM1 and IDDM2 are well described by a multiplicative genetic model, while those at IDDM1 and IDDM4 follow a heterogeneity model.
The Marketing Environment (1999)

What effect does a changing political climate have on brands? As an issue, ethics has been going up the business and branding agenda for many years. Now, judging by the new Government’s first few weeks in office, its impact on the political agenda will also be palpable.
An efficient error correction coding approach to tolerate soft error (2012)

Soft errors are significant concern for circuit reliability. Among various adopted techniques to mitigate soft errors effects on system functionality, Error Correcting Code (ECC) is one of the dominant approaches since it reduces cost overhead significantly. This paper deals with a new error correcting coding approach to tolerate soft errors at processor, data path, and memory devices of a computer system. To detect soft errors, the proposed approach introduces `modular checking' which in turns, is working (decoding and comparing) with even and/or odd numbers of row and column of a two-dimensional array organization of pre-encoded data set rather than the whole matrix. Hence, it reduces the cost by lessen the circuitry needed to implement the scheme and the detection time is reduced as well if the soft error is detected at early modular checking. The proposed approach is able to detect soft errors at any of bit positions and correct those efficiently with reduced cost as well as detection time in a great context.
Leutropin/beta-adrenergic receptor chimeras bind choriogonadotropin and adrenergic ligands but are not expressed at the cell surface (1991)

In some G-protein-coupled receptors (e.g. beta-adrenergic receptor (beta 2 AR)), the ligand-binding pocket is contained within the hydrophobic transmembrane domain. In others (e.g. luteinizing hormone receptor (LHR)), the relative roles of the extracellular N-terminal domain and the transmembrane region in hormone binding are unknown. To study the roles of these domains, we prepared vectors encoding the rat LHR N-terminal domain alone (L- -), the LHR N-terminal domain fused to the transmembrane and C-terminal domains of the vesicular stomatitis virus-G protein (LVV), the LHR N-terminal domain fused to the transmembrane and C-terminal domains of the hamster beta 2 AR (LAA), and the beta 2 AR N-terminal domain fused to the transmembrane and C-terminal domains of the rat LHR (ALL). Membrane preparations obtained from COS-7 cells expressing the beta 2 AR or LAA bound the beta-adrenergic antagonist 125I-cyanopindolol with equal affinity, confirming the observation that the beta 2 AR transmembrane domain forms the hormone-binding site. Membranes from COS-7 cells transfected with LHR bound 125I-human choriomic gonadotropin (hCG). However, membranes from LAA-, L(- -)-, and LVV-transfected cells had low capacity to bind 125I-hCG unless they were solubilized with Triton X-100. The affinity of the detergent-solubilized receptors for 125I-hCG was similar to that of the LHR. We were unable to detect binding of 125I-hCG to ALL in the presence or absence of detergent. These observations suggest that, whereas the transmembrane region of the beta 2 AR is sufficient to bind adrenergic ligands, the N-terminal region of the LHR is required for binding of hCG. Although the N terminus of the LHR is sufficient to bind hCG, both the N terminus and the transmembrane domains of the LHR are required for receptor expression on the cell surface.
Analysis of the Effect of Source Capacitance and Inductance on $N$ -Path Mixers and Filters (2017)

Switch R-C passive N-path mixers and filters enable interference-robust radio receivers with a flexibly programmable center frequency defined by a digital multi-phase clock. The radio frequency (RF) range of these circuits is limited by parasitic shunt capacitances, which introduce signal loss and degrade noise figure. Moreover, the linear periodically time varying nature of switch R-C circuits results in unwanted signal folding which needs to be suppressed by linear time- invariant (LTI) prefiltering by passive LC filters. This paper analyzes the interaction between capacitive or inductive LTI prefiltering and an N-path mixer or filter, leveraging an analysis technique based on the impulse response of the adjoint network. Previously reported results for an inductive source impedance are derived in a simpler fashion, while providing circuit intuition. Moreover, new results for N-path receivers with a shunt capacitor, and a combination of a series inductor and shunt capacitor are derived, as well as design criteria to minimize loss and frequency shifting in the peak response of these circuits.
The simulcasting technique: An approach to total-area radio coverage (1979)

The simulcasting technique described provides total-area radio coverage on an automatic basis where the use of multiple transmitter and receiver sites is required to achieve acceptable communications coverage over rugged terrain or wide areas. In this technique the same audio information is simultaneously broadcast over several transmitters operating on a single nominal-carrier frequency. Special attention must be given to transmitter-frequency stability and audio envelope characteristics. A master tone-distribution system is essential when incorporating a continuous tone-controlled squelch system (CTCSS). Use of the simulcasting technique reduces effects of fading in a mobile environment through transmitter space diversity. An application of the simulcasting technique to a coordinated FM-UHF law-enforcement communications system in Orange County, CA, is described.
Transparent Conducting Oxides—An Up-To-Date Overview (2012)

Transparent conducting oxides (TCOs) are electrical conductive materials with comparably low absorption of electromagnetic waves within the visible region of the spectrum. They are usually prepared with thin film technologies and used in opto-electrical apparatus such as solar cells, displays, opto-electrical interfaces and circuitries. Here, based on a modern database-system, aspects of up-to-date material selections and applications for transparent conducting oxides are sketched, and references for detailed information are given. As n-type TCOs are of special importance for thin film solar cell production, indium-tin oxide (ITO) and the reasonably priced aluminum-doped zinc oxide (ZnO:Al), are discussed with view on preparation, characterization and special occurrences. For completion, the recently frequently mentioned typical p-type delafossite TCOs are described as well, providing a variety of references, as a detailed discussion is not reasonable within an overview publication.
An advanced IF amplifier and AFT system suitable for HDTV (1990)

A circuit which performs the function of intermediate frequency (IF) amplification AGC (automatic gain control), AFT, and demodulation of a TV IF signal for both positive and negative modulation signals is described. The following techniques were used in developing this device: (a) a new AFT system that eliminates the need for an AFT tuned circuit; (b) a chopper stabilized phase detector which greatly reduces PLL (phase-locked loop) phase offsets and, hence, quadrature distortion; (c) wideband postdetector feedback amplifiers which reduce sound/chroma beat products; (d) a reactance tuned VCO (voltage-controlled oscillator) at half intermediate frequency; and (e) improved demodulation circuits which lower distortion. It is concluded that this system has superior performances and fewer external components and adjustments, requires no shielding, and is much easier to use than existing systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reviewer Acknowledgements for Mechanical Engineering Research, Vol. 5, No. 2 (2015)

<div>Reviewer Acknowledgements for Mechanical Engineering Research, Vol. 5, No. 2, 2015</div>
In vitro and in vivo correlations for I65T and M1V mutations at the phenylalanine hydroxylase locus (1992)

Mutations at the phenylalanine hydroxylase (PAH) locus are the major cause of hyperphenylalaninemia. We have previously described four mutations (M1V, IVS12nt1, R408W, and S349P) at the PAH locus in French Canadians with ancestry in eastern Quebec. Here we report (1) identification of another mutation, on a haplotype 9 chromosome, which converts codon 65 from isoleucine (ATT) to threonine (ACT), (2) expression analysis of the I65T mutation in COS cells demonstrating 75% loss of both immunoreactive protein and enzyme activity, and (3) expression analysis of the most prevalent PKU allele (M1V) in eastern Quebec, showing nondetectable levels of PAH protein and activity, a finding compatible with a mutation in the translation initiation codon. Homozygosity for M1V and codominant inheritance of I65T/R408W were both associated with classical phenylketonuria.
Dietary Fiber for the Treatment of Type 2 Diabetes Mellitus: A Meta-Analysis (2012)

Overall, an intervention involving fiber supplementation for type 2 diabetes mellitus can reduce fasting blood glucose and HbA1c. This suggests that increasing dietary fiber in the diet of patients with type 2 diabetes is beneficial and should be encouraged as a disease management strategy.
Sentence Production and Working Memory (1985)

Previous research has shown that subjects can make up sentences faster from related noun pairs than from unrelated pairs. Two experiments tested the proposal that for the related pairs a subject simply has to access stored information but must make up an appropriate relation for unrelated pairs. In both studies the subjects were asked on some trials to remember a digit preload while they made up their sentences. Contrary to an initial prediction, the latencies were faster rather than slower with a preload. Furthermore, a surprise recall test at the end of Experiment 2 showed that there was no difference in the recall of related and unrelated pairs. The results were interpreted as evidence that semantic work was necessary for both types of noun pairs, and that the subjects did less semantic work with a digit preload. This interpretation was further supported by the finding that with the preload the subjects produced a narrower range of semantic relations between the noun pairs.
Hypolipidemia in a Special Operations Candidate: Case Report and Review of the Literature (2015)

Individuals with presumed or proven heterozygous FHBL seeking clearance for Special Operations duty should be given precautions, undergo careful questioning for history of disease-specific complications, and should have a baseline evaluation. If negative, it seems reasonable to clear the patient for Special Operations and diving.
Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation (2016)

Leucine-rich repeat kinase 2 (LRRK2) kinase activity is increased in several pathogenic mutations, including the most common mutation, G2019S, and is known to play a role in Parkinson's disease (PD) pathobiology. This has stimulated the development of potent, selective LRRK2 kinase inhibitors as one of the most prevailing disease-modifying therapeutic PD strategies. Although several lines of evidence support beneficial effects of LRRK2 kinase inhibitors, many questions need to be answered before clinical applications can be envisaged. Using six different LRRK2 kinase inhibitors, we show that LRRK2 kinase inhibition induces LRRK2 dephosphorylation and can reduce LRRK2 protein levels of overexpressed wild type and G2019S, but not A2016T or K1906M, LRRK2 as well as endogenous LRRK2 in mouse brain, lung and kidney. The inhibitor-induced reduction in LRRK2 levels could be reversed by proteasomal inhibition, but not by lysosomal inhibition, while mRNA levels remained unaffected. In addition, using LRRK2 S910A and S935A phosphorylation mutants, we show that dephosphorylation of these sites is not required for LRRK2 degradation. Increasing our insight in the molecular and cellular consequences of LRRK2 kinase inhibition will be crucial in the further development of LRRK2-based PD therapies.
Cyclophosphamide, Doxorubicin, and Gemcitabine Combination Chemotherapy for Treatment of Metastatic and Locally Advanced Breast Cancer (2002)

Metastatic and locally advanced breast cancer remain a fertile field for investigation of new chemotherapeutic agents and chemotherapy combinations. We administered combination chemotherapy with cyclophosphamide, doxorubicin, and gemcitabine to 20 women with metastatic and/or locally advanced breast cancer. The regimen was well tolerated, although it required granulocyte colony stimulating factor (G-CSF) support. This novel regimen resulted in a complete response rate of 20% and overall response rates of 89% (intent-to-treat response of 80%). Gemcitabine is a highly effective agent that warrants farther evaluation as a component of multidrug chemotherapy.