gebhart/patrepeval huggingface dataset:
Clinical Evaluation of Calcium-Antagonist Drugs (1992)

Calcium-antagonist drugs are therapeutic agents of first choice in patients with coronary artery disease. We have reviewed a number of clinical trials in which the safety and efficacy of calcium blockers have been tested and discuss the established clinical effects of these compounds, which range from relief of angina and improved quality of life (both in patients with ischemia due to reduction in coronary flow and in patients with ischemia due to increased O2 demand) to a favorable effect on the course of coronary atherosclerosis and, finally, (at least for some of these agents) to an improvement in prognosis.
Modal control of cascaded-vehicle systems † (1970)

In this paper, control laws for cascaded-vehicle systems are derived by the application of modal control theory. It is shown that the control laws thus derived lead to much simpler control Systems than alternative systems which have been derived by the application of both continuous-time and discrete-time optimal control theory.
Hybrid CMOS-SET Inverter Design for Improved Performance using Tied Body-backgate Technique (2015)

Single-electron transistors (SETs) are an attractive candidate for future functional elements in LSIs, because of their low-power consumption and small size. Integration of current CMOS technology with the emerging SET devices is an effective approach for improving density of integration in VLSI chips and ensuring ultra low power dissipation along with the advantages of CMOS technology like high gain, current drive, speed and matured fabrication technology. This paper investigates hybrid CMOS-SET-based inverter for its functionality and performance. It then proposes and analyzes the effect of tied body-backgate technique on design metrics (propagation delay and power-delay product (PDP)). The proposed technique offers 2.38× and 4.09× improvement in propagation delay and power-delay product, respectively. Keywords: CMOS, single electron transistors, propagation delay, power delay product  Cite this Article: Gupta P, Ranu SK, Pandey MK, Islam A. Hybrid CMOS-SET Inverter Design for Improved Performance Using Tied Body-Backgate Technique. Journal of VLSI Design Tools and Technology (JoVDTT). 2015; 5(1): 24–29p.
Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats. (1992)

Tirilazad reduces cortical infarction in transient but not permanent ischemia, an effect not related to improvement in regional cerebral blood flow. Tirilazad might prove to be useful as an adjuvant therapy after successful thrombolysis in acute stroke patients.
Differences in taste between three polyethylene glycol preparations: a randomized double-blind study (2011)

Laxtra Orange(®) was most palatable preparation. This may have implications for adherence in patients with chronic constipation.
Using metrics to identify design patterns in object-oriented software (2002)

Object-oriented design patterns are an emergent technology: they are reusable micro-architectures, high level building blocks. This paper presents a conservative approach, based on a multi-stage reduction strategy using OO software metrics and structural properties to extract structural design patterns from OO design or code. Code and design are mapped into an intermediate representation, called Abstract Object Language, to maintain independence from the programming language and the adopted CASE tools. To assess the effectiveness of the pattern recovery process a portable environment written in Java, remotely accessible by means of any Web browser, has been developed. Based on this environment, experimental results obtained on public domain and industrial software are discussed in the paper.
Highly Enantioselective, Low-Temperature Epoxidation of Styrene (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly Enantioselective, Low-Temperature Epoxidation of StyreneMichael Palucki, Paul J. Pospisil, Wei Zhang, and Eric N. JacobsenCite this: J. Am. Chem. Soc. 1994, 116, 20, 9333–9334Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/ja00099a062https://doi.org/10.1021/ja00099a062research-articleACS PublicationsRequest reuse permissionsArticle Views5090Altmetric-Citations256LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Fuzzy logic-based micro power supply for MEMS applications (2002)

A severe limitation on the functional capability of remote, autonomous, microelectromechanical system (MEMS)-based sensors is the lack of a suitable micro power supply to power these devices. Such sensors often have low power requirements that may be provided by the combination of an energy scavenger (e.g., a solar cell) and a rechargeable microbattery made using integrated circuit fabrication methods. While rechargeable /spl mu/batteries and solar cells have been previously demonstrated, the development of a micro-charge/discharge controller has not. In this paper, the authors present a novel fuzzy logic-based solar charge controller that allows control of the charge/discharge of /spl mu/batteries. A breadboard implementation of the controller and its integration with a solar cell and /spl mu/battery are presented. The circuit topology of the /spl mu/battery controller is based on a buck converter design. During charging, the solar cell's operating point is adjusted by modulating the duty cycle of the buck converter's switching MOSFET using a fuzzy logic control algorithm to optimally charge the /spl mu/battery.
Secure Cloud Container: Runtime Behavior Monitoring Using Most Privileged Container (MPC) (2017)

Hypervisor-based virtualization rapidly becomes a commodity, and it turns valuable in many scenarios such as resource optimization, uptime maximization, and consolidation. Container-based application virtualization is an appropriate solution to develop a light weighted partitioning by providing application isolation with less overhead. Undoubtedly, container based virtualization delivers a lightweight and efficient environment, however raises some security concerns as it allows isolated processes to utilize an underlying host kernel. A new security layer with the Most Privileged Container (MPC) is proposed in this article. The proposed MPC layer exhibits three main functional blocks: Access policies, Black list database, and Runtime monitoring. The introduced MPC layer implements privilege based access control and assigns resource access permissions based on policies and the security profiles of containerized application user processes. Furthermore, the monitoring block examines the runtime behavior of containers and black list database is updated if the container violets its policies. The proposed MPC layer provides higher level of application container security against potential threats.
Long‐term Effects of 222‐nm ultraviolet radiation C Sterilizing Lamps on Mice Susceptible to Ultraviolet Radiation (2020)

Germicidal lamps that emit primarily 254 nm ultraviolet radiation (UV) are routinely utilized for surface sterilization but cannot be used for human skin because they cause genotoxicity. As an alternative, 222-nm UVC has been reported to exert sterilizing ability comparable to that of 254-nm UVC without producing cyclobutane pyrimidine dimers (CPDs), the major DNA lesions caused by UV. However, there has been no clear evidence for safety in chronic exposure to skin, particularly with respect to carcinogenesis. We therefore investigated the long-term effects of 222-nm UVC on skin using a highly photocarcinogenic phenotype mice that lack xeroderma pigmentosum complementation group A (Xpa-) gene, which is involved in repairing of CPDs. CPDs formation was recognized only uppermost layer of epidermis even with high dose of 222-nm UVC exposure. No tumors were observed in Xpa-knockout mice and wild-type mice by repetitive irradiation with 222-nm UVC, using a protocol which had shown to produce tumor in Xpa-knockout mice irradiated with broad-band UVB. Furthermore, erythema and ear swelling were not observed in both genotype mice following 222-nm UVC exposure. Our data suggest that 222-nm UVC lamps can be safely used for sterilizing human skin as far as the perspective of skin cancer development.
Haptic display of interaction between textured models (2005)

Surface texture is among the most salient haptic characteristics of objects; it can induce vibratory contact forces that lead to perception of roughness. In this paper, we present a new algorithm to display haptic texture information resulting from the interaction between two textured objects. We compute contact forces and torques using low-resolution geometric representations along with texture images that encode surface details. We also introduce a novel force model based on directional penetration depth and describe an efficient implementation on programmable graphics hardware that enables interactive haptic texture rendering of complex models. Our force model takes into account important factors identified by psychophysics studies and is able to haptically display interaction due to fine surface textures that previous algorithms do not capture.
Tumor Spheres Quantification with Smoothed Euclidean Distance Transform (2018)

Tumor sphere quantification plays an important role in cancer research and drugs screening. Even though the number and size of tumor spheres can be found manually, this process is time-consuming, prone to making errors, and may not be viable when the number of images is very large. This manuscript presents a method for automated quantification of spheres with a novel segmentation technique. The segmentation method relies on initial watershed algorithm which detects the minima of the distance transform and finds a tumor sphere for each minimum. Due to the irregular edges of tumor spheres, the distance transform matrix has often more number of minima than the true number of spheres. This leads to the over segmentation problem. The proposed approach uses the smoothed form of the distance transform to effectively eliminate superfluous minima and then seeds the watershed algorithm with the remaining minima. The proposed method was validated over pancreatic tumor spheres images achieving high efficiency for tumor spheres quantification.
Making microgrids work (2008)

Distributed energy resources including distributed generation and distributed storage are sources of energy located near local loads and can provide a variety of benefits including improved reliability if they are properly operated in the electrical distribution system. Microgrids are systems that have at least one distributed energy resource and associated loads and can form intentional islands in the electrical distribution systems. This paper gives an overview of the microgrid operation. Microgrid testing experiences from different counties was also provided.
Prediction of Properties of Coir Fiber Reinforced Composite by ANN (2013)

In the present study the mechanical properties of coir reinforced epoxy resin composite is predicted by using ANN approach. The experimental study by using short coconut coir fibers reinforced with Epoxy LY556 resin composite is reported in earlier studies. The coir fibers collected from Orissa, India, used in lengths of 5, 20 and 30 mm with 30 % fiber and 70 % matrix are used. Experiments conducted as per ASTM standards, and results of tensile, flexural, and impact strengths are reported. It is also reported that the fiber length is having significant effect on the properties of composites. The traditional experimental methods used in obtaining the properties of composites is expensive, require human resources, time consuming and human errors may occur. To reduce the above drawbacks, the present study is under taken to develop a weighted matrix between input (Fiber Length) and output (properties). ANN’s training and its testing are adopted to fix the appropriate weighted matrix which in turn prognosticates the appropriate mechanical properties of coir fiber reinforced epoxy resin composites. Similar trend in the variation of tensile strength, flexural strength and impact strength were obtained in the prediction using ANN and they compared well with the experimental results reported.
RoadSurf: a modelling system for predicting road weather and road surface conditions (2015)

Forecasting of road surface and traffic conditions is an important aspect of traffic safety and winter road maintenance, especially in the harsh northern climate. The weather conditions can change quickly, for example, with the onset of snowfall or during rapid temperature variations. A prior knowledge of road weather is important from a public road safety standpoint. Proper consideration of upcoming weather events also helps the road maintenance authorities to attend the roads in an effective and economical manner. In Finland, the Finnish Meteorological Institute (FMI) is duty bound to issue warnings of hazardous traffic conditions to the general public. To strengthen these services towards more efficient estimation of rapidly varying conditions of the road surface at a national scale, a simulation model, RoadSurf, has been developed. As input, the model employs numerical weather forecasts, either directly or after modifications made by meteorologists, as well as observations from synoptic or road weather stations and radar precipitation measurement network. As output, the model produces not only road surface temperature, but also road surface condition classification and a traffic index describing the driving conditions in more general terms, as well as road surface friction. The model has been in operational use since 2000. In addition to the original goal of providing road weather forecasts for the national road network, the model has been used in several other applications, for example, in predicting pedestrian sidewalk conditions and in numerous intelligent traffic applications. The present study describes the road weather model RoadSurf and its main applications.
Indirect Competitive ELISA for Determination of Traces of Peanut (<i>Arachis hypogaea </i>L.) Protein in Complex Food Matrices (1999)

An indirect competitive ELISA was developed allowing the detection of hidden peanut protein residues down to 2 ppm (micorgrams per gram) in various foods. The high-titer, peanut-specific polyclonal antiserum used recognized potentially allergenic proteins in both native and roasted peanuts. In the absence of a food matrix, extractable protein from roasted peanuts was detected at 104 +/- 13%. From various food items, peanut protein at > or =13 ppm was recovered between 84 and 126%, and at 2 ppm of peanut protein recovery was 143 +/- 6%. Intra- and interassay precision was <15%. In 5 of 17 commercial food products without declaration of peanut components, between 2 and 18 ppm of peanut protein was detected. This is the first assay based on commercially available reactants that allows the reliable determination of trace amounts of hidden peanut allergens in a variety of complex food matrices.
Wearable, Human‐Interactive, Health‐Monitoring, Wireless Devices Fabricated by Macroscale Printing Techniques (2014)

Wearable human‐interactive devices are advanced technologies that will improve the comfort, convenience, and security of humans, and have a wide range of applications from robotics to clinical health monitoring. In this study, a fully printed wearable human‐interactive device called a “smart bandage” is proposed as the first proof of concept. The device incorporates touch and temperature sensors to monitor health, a drug‐delivery system to improve health, and a wireless coil to detect touch. The sensors, microelectromechanical systems (MEMS) structure, and wireless coil are monolithically integrated onto flexible substrates. A smart bandage is demonstrated on a human arm. These types of wearable human‐interactive devices represent a promising platform not only for interactive devices, but also for flexible MEMS technology.
The Hsp90 chaperone as a promising drug target. (2001)

Geldanamycin and radicicol, antibiotics produced by Streptomycetes and fungi, respectively, were originally discovered many years ago. Only recently was it discovered that they bind with high specificity within the ADP/ATP binding pocket of the Hsp90 molecular chaperone, thereby inhibiting the function of Hsp90. In eukaryotic cells Hsp90 catalyzes the final activation step of many of the most important regulatory proteins. Cells that lose this function are severely compromised and cannot progress through the cell cycle. In cell-culture systems, the administration of geldanamycin induces degradation of several signal transduction proteins of oncological importance. Hsp90 inhibitors are, therefore, now attracting considerable attention as potential antitumor agents; one geldanamycin derivative is already in phase I trials as an anticancer drug. These drugs may also have virucidal, antimalarial and ischemia-protective effects.
Partitioning of Olive Oil Antioxidants between Oil and Water Phases (2002)

The partition coefficient (K(p)) of the natural phenolic antioxidant compounds in the olive fruit between aqueous and olive oil phases was determined. The antioxidants of olive oil are either present in the olive fruit or formed during the olive oil extraction process. The antioxidants impart stability to and determine properties of the oil and are valuable from the nutritional point of view. The olive oil antioxidants are amphiphilic in nature and are more soluble in the water than in the oil phase. Consequently, a large amount of the antioxidants is lost with the wastewater during processing. The determination of antioxidants was performed using HPLC, and the K(p) was estimated to be from as low as 0.0006 for oleuropein to a maximum of 1.5 for 3,4-DHPEA-EA (di-hydroxy-phenyl-ethanol-elenolic acid, oleuropein aglycon). Henry's law fitted very well to the experimental data. The partition coefficients were also estimated by applying the activity coefficients of the antioxidants in the two phases using a predictive group contribution method, the UNIFAC equation. The K(p) values estimated with UNIFAC method were of the same order of magnitude but varied from the experimental values. Nevertheless, this method may be a rough predictive tool for process optimization or design. Because the K(p) values were very low, some changes in the process are recommended in order to achieve a higher concentration of antioxidants in the oil. A temperature increase may lead to increasing the partition coefficient. Also, limiting the quantity of water during oil extraction could be a basis for designing alternative processes for increasing the antioxidant concentration in the olive oil.
Carbon isotope fluctuations in Precambrian carbonate sequences of several localities in Brazil (2000)

Carbon isotope fluctuations in Precambrian sedimentary carbonates between 2.8 Ga and 0.60 Ga in Brazil are examined in this study. The carbonate facies of the BIF of the 2.8 Ga-old Carajás Formation, state of Pará in northern Brazil, has rather homogeneous delta13C (-5 o/ooPDB), compatible with carbonatization of a silicate protolith by a CO2-rich fluid from mantle degassing. The Paleoproterozoic Gandarela Formation, state of Minas Gerais, displays a narrow delta13C variation (-1.5 to +0.5 o/oo) compatible with carbon isotope signatures of carbonates deposited around 2.4 Ga worldwide. The Fecho do Funil Formation has probably recorded the Lomagundi delta13C positive anomaly (+6.4 to +7.1 o/ooPDB). The magnesite-bearing carbonates of the Orós mobile belt, state of Ceará, exhibit carbon isotope fluctuation within the range for carbonates deposited at 1.8 Ga. The C-isotope record of the Frecheirinha Formation, northwestern state of Ceará, shows negative delta13C values in its lower portion (-2 o/oo) and positive values up section (+1 to +3 o/oo), which suggests this sequence is a cap carbonate deposited after a glacial event around 0.95 Ga. The Jacoca and Acauã sedimentary carbonate Formations, state of Sergipe, NE Brazil, show carbon isotope fluctuations very similar to each other (average around -5 o/oo), compatible with a deposition around 0.76 Ga. The younger Olho D'Água carbonate Formation, however, also in the state of Sergipe, displays negative delta13C values at the lower portion of the Formation, changing dramatically up section to positive values as high as +10 o/oo, a characteristic compatible with a Sturtian cap carbonate deposited around 0.69 Ga. On the light of the C isotope data discussed in this study, it seems that delta13C fluctuations in Paleoproterozoic carbonates in Brazil are within the range found globally for metasedimentary carbonates of this age. Carbon isotope data proved to be very useful in establishing relative chronology of Neoproterozoic carbonate formations for which precise radiometric ages are not available.
The Unfinished Measles Immunization Agenda (2003)

Despite achieving and sustaining global measles vaccination coverage of about 80% over the past decade, worldwide measles remains the fifth leading cause of mortality among children aged <5 years. In May 2002, the United Nations Special Session on Children endorsed the goal of reducing measles deaths by half by 2005. Countries and World Health Organization (WHO) regions that adopted aggressive measles control or elimination strategies have shown excellent results. In 2001, countries in the Americas reported an all time low of 537 confirmed measles cases. Substantial progress in measles control has also been achieved in the WHO Western Pacific Region, in seven southern African countries, and in selected countries in WHO European, Eastern Mediterranean, and Southeast Asian regions. The ongoing measles disease burden and availability of safe and effective measles mortality reduction strategies make a compelling case to complete the unfinished agenda of measles immunization.
Cathodic protection of a remote river pipeline (1994)

The 261-km long 500-mm diam Kutubu pipeline, which runs through dense jungle swamps in Papua, New Guinea, was built for Chevron Niugini to transport oil from the remote Kutubu oil production facility in the Southern Highlands to an offshore loading facility. The pipeline was laid with a section in the bed of a wide, fast-flowing river. This section was subject to substantial telluric effects and current density variations from changing water resistivities. The cathodic protection system's effectiveness was monitored by coupon off'' potentials and required an innovative approach.