gebhart/patrepeval huggingface dataset:
Shared Experiences of Technology and Trust: An Experimental Study of Physiological Compliance Between Active and Passive Users in Technology-Mediated Collaborative Encounters (2014)

The aim of this study is to examine the utility of physiological compliance (PC) to understand shared experience in a multiuser technological environment involving active and passive users. Common ground is critical for effective collaboration and important for multiuser technological systems that include passive users since this kind of user typically does not have control over the technology being used. An experiment was conducted with 48 participants who worked in two-person groups in a multitask environment under varied task and technology conditions. Indicators of PC were measured from participants' cardiovascular and electrodermal activities. The relationship between these PC indicators and collaboration outcomes, such as performance and subjective perception of the system, was explored. Results indicate that PC is related to group performance after controlling for task/technology conditions. PC is also correlated with shared perceptions of trust in technology among group members. PC is a useful tool for monitoring group processes and, thus, can be valuable for the design of collaborative systems. This study has implications for understanding effective collaboration.
Statistics and performance under combined impairments induced by polarization-dependent-loss in polarization-division-multiplexing digital coherent transmission (2011)

Two-dimensional statistics and Q-penalty performance under the combination of two major impairments induced by polarization-dependent loss, namely level imbalance and loss of orthogonality between polarization-multiplexed tributaries, for a polarization-division-multiplexing digital coherent transmission at over 100-Gb/s are presented for the first time to estimate the outage probability needed for designing the system.
A Comparative <sup>13</sup>C‐NMR. Study on Various Reduced Flavins (1980)

Abstract Various two‐electron reduced flavin derivatives have been investigated by natural abundance 13 C‐NMR. spectroscopy. Some selectively 13 C‐enriched compounds were synthesized to ensure the assignment of some of the quaternary C‐atoms of the flavin molecule. Addition of two electrons to oxidized flavin leads to upfield shifts of all resonances except for those due to C(5a), C(9) and C(10′α). The largest upfield shift is observed for C(4a). Also some direct and two‐bond coupling constants are reported. Theoretical calculations by INDO show that a rather good correlation exists between the calculated π‐electron densities and the observed chemical shifts of the two‐electron reduced molecule. For the oxidized molecule, the correlation is less satisfactory. Most substitution effects are additive, but some deviations in some compounds are observed indicating structural differences between the compounds in question. The chemical shifts are also discussed in terms of the chemical reactivity of the oxidized and reduced flavin molecule.
Model predictive vehicle control with side slip angle restriction with suppression of modeling error by sliding mode control (2014)

In this paper, we propose a robust model predictive vehicle control with restriction of wheel side-slip angle. The proposed method confines the wheel side slip angle to the range of small value in order to linearize the force model and to avoid tire force saturation which strongly depends on the tire-road coefficient of friction. The linearization greatly helps to improve the computational speed on model predictive control. To cope with both the linearization error and the influence of uncertainty of road surface condition, we introduce sliding mode control and suppress the disturbance due to them. The effectiveness of the proposed method is verified by comparative simulations.
Initial medical management of patients severely irradiated in the Tokai-mura criticality accident (2003)

A nuclear criticality accident occurred in Japan on September 30, 1999, which resulted in severe exposure of three victims to mixed flux of neutrons and gamma-rays. Estimated average doses for the three victims were 5.4 Gy of neutrons and 8.5 Gy of gamma-rays for Patient A, 2.9 Gy of neutrons and 4.5 Gy of gamma-rays for Patient B, and 0.81 Gy of neutrons and 1.3 Gy of gamma-rays for Patient C. They then suffered the consequences of the effects of ionizing radiation resulting in acute radiation syndrome. In Patients A and B, bone marrow failure was so severe that they received haematopoietic stem cell transplantation. The graft initially took successfully in both patients, although in Patient B it was later taken over by his own haematopoietic cells. They also suffered from severe skin lesions, later exhibited gastrointestinal bleeding and eventually died of multiple organ failure 82 and 210 days after the accident, respectively. The survival of these patients beyond the period of agranulocytosis means that bone marrow failure per se caused by exposure to ionizing radiation may now be overcome. Patient C also developed bone marrow failure and was treated with granulocyte colony-stimulating factor as well as supportive care. He recovered without major complications and is now under periodical follow-up. Remarkably, during the prodromal phase, all the patients exhibited hypoxaemia, two of whom also showed interstitial oedema of the lungs. In Patient C these manifestations improved within a week. The circumstances of the accident and the initial medical treatment of the victims are described.
Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. (1996)

Tissue factor (TF) is the cellular receptor for coagulation factor VI/VIIa and is the membrane-bound glycoprotein that is generally viewed as the primary physiological initiator of blood coagulation. To define in greater detail the physiological role of TF in development and hemostasis, the TF gene was disrupted in mice. Mice heterozygous for the inactivated TF allele expressed approximately half the TF activity of wild-type mice but were phenotypically normal. However, homozygous TF-/- pups were never born in crosses between heterozygous mice. Analysis of mid-gestation embryos showed that TF-/- embryos die in utero between days 8.5 and 10.5. TF-/- embryos were morphologically distinct from their TF+/+ and TF+/- littermates after day 9.5 in that they were pale, edematous, and growth retarded. Histological studies showed that early organogenesis was normal. The initial failure in TF-/- embryos appeared to be hemorrhaging, leading to the leakage of embryonic red cells from both extraembryonic and embryonic vessels. These studies indicate that TF plays an indispensable role in establishing and/or maintaining vascular integrity in the developing embryo at a time when embryonic and extraembryonic vasculatures are fusing and blood circulation begins.
Transforming growth factor-alpha expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-alpha complementary DNA leads to transformation. (1990)

MCF-10A cells are a spontaneously immortalized normal human mammary epithelial cell line. MCF-10A cells were transfected with two expression vector plasmids containing either a human point-mutated c-Ha-ras protooncogene or the rat c-neu protooncogene. c-Ha-ras-transfected MCF-10A cells grow as colonies in soft agar, exhibit a 3- to 4-fold increase in their growth rate in serum-free medium, and show a reduced mitogenic response to exogenous epidermal growth factor (EGF) or transforming growth factor-alpha (TGF alpha) as compared to MCF-10A cells. c-Ha-ras-transfected MCF-10A cells express a 4- to 8-fold increase in TGF alpha mRNA levels and secrete 4- to 6-fold more TGF alpha protein as compared to MCF-10A cells. Addition of either an anti-TGF alpha neutralizing monoclonal antibody or an anti-EGF receptor blocking monoclonal antibody to the Ha-ras-transformed MCF-10A cells produces a 50 to 80% inhibition of colony formation of these cells in soft agar. c-neu-transfected MCF-10A cells grown in soft agar and exhibit an increase in their growth rate in serum-free medium at a level comparable to that observed in Ha-ras-transformed MCF-10A cells. Addition of an anti-c-erbB-2 monoclonal antibody inhibits the anchorage-independent growth of these cells in soft agar. However, c-neu-transformed MCF-10A cells show no increase in TGF alpha secretion and no change in their responsiveness to exogenous EGF or TGF alpha. A recombinant retroviral vector containing the human TGF alpha gene was also introduced into MCF-10A cells. TGF alpha-infected MCF-10A cells secrete 15- to 20-fold more TGF alpha protein than MCF-10A cells, form colonies in soft agar, exhibit an enhanced growth rate in serum-free medium, and show a decreased mitogenic response to exogenous EGF or TGF alpha at a level equivalent to Ha-ras-transformed MCF-10A cells. Growth of TGF alpha-infected MCF-10A cells in soft agar is completely inhibited by anti-TGF alpha neutralizing or anti-EGF receptor blocking monoclonal antibodies. These results suggest that TGF alpha is an intermediary in the transformation of human mammary epithelial cells by an activated c-Ha-ras gene, but not by the c-neu gene, and demonstrate that overexpression of this growth factor is able to transform immortalized human mammary epithelial cells which also express a sufficient complement of functional EGF receptors.
CMOS Well drive-In in NH<sub>3</sub>for reduced lateral diffusion and heat cycle (1985)

CMOS n-well drive-in performed in an NH <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> ambient is described. Experimental results on the reduction of heat cycle and lateral diffusion as well as the effects on device characteristics and latch-up are discussed.
Recording Strategies, Reference Issues, and Dipole Localization (2006)

Abstract Every EEG measurement depends on the locations of the recording and so-called reference electrode. The measured potential difference is a property of the path between electrode pairs. This applies to any reference including the linked-ears (or linked-mastoid) reference. The physical linked-ears reference provides an unbalanced “random” reference. The mathematical linked-ears reference offers no obvious advantages over other references. The average reference can be used to approximate reference independent potentials if used with a large number of electrodes, but is still biased by the limited sampling of potentials over the lower surface of the head. Regardless of source, the EEG is a low-pass spatially filtered signal, making discrete sampling of the potential distribution feasible without spatial aliasing. Modern EEG systems have facilitated spatial mapping of EEG potentials. Any potential distribution on the scalp can be fit (in a least-squared sense) by an equivalent dipole distribution by solving the inverse problem.
Service selection algorithms for Web services with end-to-end QoS constraints (2004)

Web services are new forms of Internet software that can be universally deployed and invoked using standard protocol. Services from different providers can be integrated to provide composite services. In this paper, we study the end-to-end QoS issues of composite service by utilizing a QoS broker that is responsible for coordinating the individual service component to meet the quality constraint. We design the service selection algorithms used by QoS brokers to meet end-to-end QoS constraints. The objective of the algorithms is to maximize the user-defined utility while meeting the end-to-end delay constraint. We model the problem as the multiple choice knapsack problem (MCKP) and provide efficient solutions. The algorithms are tested for their performance.
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation (2013)

Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy of Lsd1, genome-wide analysis of its substrates H3K4 monomethylation and dimethylation, and gene expression profiling, reveals that Lsd1 represses hematopoietic stem and progenitor cell (HSPC) gene expression programs during hematopoietic differentiation. We found that Lsd1 acts at transcription start sites, as well as enhancer regions. Loss of Lsd1 was associated with increased H3K4me1 and H3K4me2 methylation on HSPC genes and gene derepression. Failure to fully silence HSPC genes compromised differentiation of hematopoietic stem cells as well as mature blood cell lineages. Collectively, our data indicate that Lsd1-mediated concurrent repression of enhancer and promoter activity of stem and progenitor cell genes is a pivotal epigenetic mechanism required for proper hematopoietic maturation. DOI:http://dx.doi.org/10.7554/eLife.00633.001.
Structure and In Vitro Antiviral Activity of Sesquiterpene Glycosides from Calendula arvensis (1990)

Previous research on the aerial parts of Calendula arvensis led to the isolation of the epicubebol glycoside 1 and of the sesquiterpene glycosides 2-5 based on the alloaromadendrane skeleton. A further investigation has revealed two new glycosides, 6 and 7, derived from the same sesquiterpene, the structures of which were elucidated by spectral studies. Furthermore a series of antiviral tests has been performed on glycosides 1-7 by examining their ability to interfere with rhinovirus 1B and vesicular stomatitis virus infection in vitro. Only glycoside 1 slightly reduced rhinovirus multiplication. All the compounds were able to inhibit vesicular stomatitis virus infection, 1 and 2 being the most effective.
A putative vacuolar cargo receptor partially colocalizes with AtPEP12p on a prevacuolar compartment in <i>Arabidopsis</i> roots (1998)

Targeting of protein cargo to the vacuole/lysosome is a multistep process that appears to have conserved features between mammalian, yeast, and plant cells. In each case, some soluble vacuolar/lysosomal proteins are believed to be bound by transmembrane cargo receptors in the trans-Golgi network (TGN) that redirect these proteins into clathrin-coated vesicles. These vesicles then appear to be transported to the prevacuole/endosome by a trafficking machinery that requires components identified in other vesicle-targeting steps such as N-ethylmaleimide-sensitive factor (NSF), soluble NSF attachment protein (SNAP), SNAP receptors (SNAREs), rab-type GTPases, and Sec1p homologs. Two likely members of this trafficking machinery have been characterized from Arabidopsis thaliana: AtPEP12p, a t-SNARE that resides on a what we now call a prevacuolar compartment, and AtELP, a protein that shares many common features with mammalian and yeast transmembrane cargo receptors. Here, we have further investigated the intracellular distribution of AtELP. We have found that AtELP is located at the trans-Golgi of Arabidopsis root cells, and that its C terminus can preferentially interact in vitro with the mammalian TGN-specific AP-1 clathrin-adapter complex, suggesting a likely role in clathrin-coated, vesicle-directed trafficking at the TGN. Further, consistent with a role in trafficking of vacuolar cargo, we have found that AtELP partially colocalizes with AtPEP12p on a prevacuolar compartment.
A new sensitive determination method of estradiol in plasma using peroxyoxalate ester chemiluminescence combined with an HPLC system (2000)

A new sensitive determination method of estradiol in a plasma sample using peroxyoxalate ester chemiluminescence was developed. Estradiol, which was extracted by liquid-liquid extraction using ethyl acetate from plasma, was derivatized with dansyl-chloride (DNS-Cl) and separated by reverse-phase HPLC. The performance of four oxalates, bis(trichlorophenyl)oxalate (TCPO), bis(2,4-dinitrophenyl)oxalate (DNPO), bis(pentafluorophenyl)oxalate (PFPO), and bis[4-nitro-2-(3,6, 9-trioxadecyloxycarbonyl)phenyl] oxalate (TDPO), were evaluated using the static system, and DNPO was found to have the most sensitive and stable chemiluminescence at a H(2)O(2) concentration of 30 mM. HPLC-chemiluminescence system using DNPO for the determination of estradiol was established. The detection limit of dansylated-estradiol (DNS-E2) was 15 fmol (4 pg) in the standard solution and 44 fmol (12 pg) in the rat plasma sample at S/N = 3.
3D seismic volume visualization and interpretation: An integrated workflow with case studies (2008)

Abstract One of the major problems in subsurface seismic exploration is the uncertainty (nonuniqueness) in geologic interpretation because of the complexity of subsurface geology and the limited dimension of the data available. Case studies from worldwide exploration projects indicate that an integrated, three-dimensional (3D) seismic volume visualization and interpretation workflow contributes to resolving the problem by mining and exposing critical geologic information from within seismic data volumes. Following 3D seismic data acquisition and processing, the interpretation workflow consists of four integrated phases from data selection and conditioning, to structure and facies characterization, to prospect evaluation and generation, to well-bore planning. In the data selection and conditioning phase, the most favored and frequently used data are the full-angle, limited-angle, and limited-azimuth stack amplitude with significant structure and facies enhancements. Signal-to-noise ratio, color scheme, dynamic range, bit resolution, and visual contrast all affect thevisibility of features of interest. In the structure and facies characterization phase, vertical slicing along arbitrary traverses demonstrates structure styles, stratigraphic architecture, and reservoir geometry in the cross-sectional view. Time/depth slicing defines lateral and vertical variability in the structural trend and areal extent in the map view. Stratal slicing and fault slicing map chronostratigraphic seismic facies and cross-stratal, along-fault seismic signature. Volume flattening and structure restoration aid in unraveling paleostructural framework and stratigraphic architecture and their growth histories. In the prospect evaluation and generation phase, a combination of volume trimming, co-rendering, transparency, attribute analysis, and attribute-body detection is instrumental in delineating volumetric extent and evaluating spatial connectivity of critical seismic features. Finally, in the well-bore planning phase, informed decision-making relies on the integration of all the information and knowledge interrogated from 3D seismic data. Most importantly, interpreters’ geologic insight and play concept are crucial to optimal well-bore planning with high geologic potential and low economic risk.
Radio Frequency Ablation in the Rabbit Lung Using Wet Electrodes: Comparison of Monopolar and Dual Bipolar Electrode Mode (2006)

Using a wet electrode, dual electrode bipolar RFA can create a larger ablation zone more efficiently than monopolar RFA.
使用光学聚合物微透镜实现高速亚微米显微镜 (2009)

We report the high speed scanning submicronic microscopy (SSM) using a low cost polymer microlens integrated at the extremity of an optical fiber. These microlenses are fabricated by a free-radical photopolymerization method. Using a polymer microlens with a radius of curvature of 250 nm, a sub-micrometric gold pattern is imaged experimentally by SSM. Different distances between the tip and the sample are used with a high scanning speed of 200 cm/s. In particular, metallic absorption contrasts are described with an optical spatial resolution of 250 nm at the wavelength of 532 nm. Moreover, finite-difference time-domain (FDTD) simulations concerning the focal lengths of microlenses with different geometries and heights support the experimental data.
Recent concepts in thermoelectric power generation (2003)

The development of economic thermoelectric generators for waste heat recovery has become an increasing research focus over the past a few years. Traditionally, attempts to improve their economic viability have concentrated primarily on improving the conversion efficiency by increasing the figure-of-merit of thermoelectric materials, with only marginal successes. This paper explores the possibilities and implications of alternative approaches in an attempt to improve the economic competitiveness of thermoelectric generators based on currently available materials (i.e., with ZT/spl sim/1). Novel concepts which provide alternative approaches to overcome low efficiency drawback are discussed and examples presented, typical of which include high-power-density thermoelectric generating modules; symbiotic systems for co-generation of heat and power; high efficiency heat-recirculating thermoelectric-combustion systems and thermoelectric microgenerators.
Compact image stabilization system using camera posture information (2008)

Abstract A teleoperated robot that works in unstructured environments such as disaster sites is mainly controlled based on images obtained from cameras mounted on the robot. Because the robot runs on rough terrains, the images from the mounted camera are nonsteady ones. These nonsteady images will make it difficult for the operator to understand the surrounding information and will cause the camera motion sickness. We have developed an image stabilization system using camera posture information for a mobile robot that moves on uneven terrains. Because the camera posture information is detected by a three‐dimensional‐motion sensor separately from the camera image, this system works even in bad light condition environments and is robust for light condition changes. The wide‐field‐of‐view images obtained by the fish‐eye‐lens camera are used to handle a large‐amplitude disturbance. The sphere mapping and the image shifting of a region of © 2008 Wiley Periodicals, Inc.
Virtual Reality Exposure Therapy for the Treatment of Posttraumatic Stress Disorder Following September 11, 2001 (2007)

Our preliminary data suggest that VR is an effective treatment tool for enhancing exposure therapy for both civilians and disaster workers with PTSD and may be especially useful for those patients who cannot engage in imaginal exposure therapy.
Synthesis and Evaluation of New Hsp90 Inhibitors Based on a 1,4,5-Trisubstituted 1,2,3-Triazole Scaffold (2014)

Ruthenium catalyzed 1,3-cycloaddition (click chemistry) of an azido moiety installed on dihydroxycumene scaffold with differently substituted aryl propiolates gave a new family of 1,4,5-trisubstituted triazole carboxylic acid derivatives that showed high affinity toward Hsp90 associated with cell proliferation inhibition, both in nanomolar range. The 1,5 arrangement of the resorcinol, the aryl moieties, and the presence of an alkyl (secondary) amide in position 4 of the triazole ring were essential to get high activity. Docking simulations suggested that the triazoles penetrate the Hsp90 ATP binding site. Some 1,4,5-trisubstituted triazole carboxamides induced dramatic depletion of the examined client proteins and a very strong increase in the expression levels of the chaperone Hsp70. In vitro metabolic stability and in vivo preliminary studies on selected compounds have shown promising results comparable to the potent Hsp90 inhibitor NVP-AUY922. One of them, (compound 18, SST0287CL1) was selected for further investigation as the most promising drug candidate.