gebhart/patrepeval huggingface dataset:
DO Get Technical! Using Technology in Library Instruction WILU 2011, Regina, SK (2011)

Today’s post-secondary students are digital natives. Much has been said and written about how to reach this generation, and the consensus seems to be that we need to meet them on their turf. In this session, presented at WILU 2011 in Regina, SK, two librarians from the University of Lethbridge shared their experiences with using technology to engage students in library instruction. The hands-on session introduced some simple tools librarians can learn quickly and apply to spice up their instruction with technology. These include creating online animated videos using Xtranormal, a lowcost way to create polished and humorous videos to introduce or summarize key information literacy concepts; and adding interactive polling to PowerPoint presentations using a tool called Poll Everywhere, which is an effective way to instantly engage students in instruction using the web or web-enabled devices. Interactive polling eliminates many of the challenges of using clickers which are prevalent in many postsecondary library instruction environments. The presenters also discussed how they have experimented with wikis to encourage active learning and student collaboration in a series of library instruction sessions. Wikis allow for free and paperless student participation in knowledge creation in an online forum. Finally, they demonstrated how they have used Skype to deliver library instruction at a distance, including the use of the screen sharing feature. The presenters stressed the ease of use of these free or lowcost tools to improve classroom engagement and add interest to sessions.
Effects of simvastatin, a cholesterol synthesis inhibitor, on phosphatidylcholine synthesis in HepG2 cells. (1994)

The effects of the addition of a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, simvastatin, to the medium on sterol synthesis and phosphatidylcholine (PC) synthesis were studied in HepG2 cells. The cells were cultured with simvastatin at concentrations of 10(-7) and 10(-6) mol/L for 6 hours, and radioactive lipid precursors were added 1 hour before harvesting. Simvastatin inhibited cholesterol synthesis from [14C]acetate in a dose-dependent manner. It also decreased the incorporation of [14C]choline into PC by 30%; this decrease was accompanied by a decrease in phosphocholine cytidylyltransferase activity in cell homogenates. Simvastatin had no significant effects on the incorporation of [3H]glycerol into phospholipids. These data indicate that simvastatin has two different functions: inhibition of HMG-CoA reductase and depression of de novo synthesis of PC via the cytidine diphosphate-choline pathway, which, in turn, may result in a decrease in plasma lipid levels.
Source-Bias Dependent Charge Accumulation in P<sup>+</sup>-Poly Gate SOI Dynamic Random Access Memory Cell Transistors (1998)

In this paper, we report the dynamic data retention problems caused by the transient leakage current in a cell transistor during the bit-line pull down operation in p + -poly gate fully depleted silicon-on-insulator (FD-SOI) dynamic random access memories (DRAMs) due to the source-induced charge accumulation (SICA) effect in the silicon thin film. Due to the inherent floating body effect in the FD-SOI transistor, charge accumulation in the silicon thin film becomes inevitable when the gate-to-source voltage ( V GS ) is smaller than the flat-band voltage ( V FB ). In order to eliminate the transient leakage current problem in p + -poly gate FD-SOI cell transistor, the ground-precharged bit-line (GPB) sensing method is introduced.
On Optimum Methods in Quickest Detection Problems (1963)

In this paper optimum methods are developed for observing a process (1), in which the moment when a “disorder” $\theta$ appears is not known. The basic quantity characterizing the quality of this observation method is the mean time delay ${\boldsymbol \tau}$ for detection of a disorder. After making assumption (4) it is shown that for a given false alarm probability $\omega$ or for a given ${\bf N}$ — mathematical expectation of false alarm numbers occurring up to the moment the disorder appears — the observation method minimizing ${\boldsymbol \tau } = {\boldsymbol \tau } (\omega)$ or ${\boldsymbol \tau} = {\boldsymbol \tau} ({\boldsymbol N})$ is based on an observation of a posteriors probability (23). In § 3 a case is considered, wherein, the disorder appears on the background of steadystate conditions arising when the disorder is absent. A method is found for minimizing ${\boldsymbol \tau} = {\boldsymbol \tau} ({\bf T})$ for a set ${\bf T}$ — mathematical expectation of the time between two false alarms. The dependence ${\boldsymbol \tau} = {\boldsymbol \tau} ({\bf T})$ is given by formula (36).
Identification of 12 novel mutations in the alpha-N-acetylglucosaminidase gene in 14 patients with Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB). (1998)

Sanfilippo syndrome type B or mucopolysaccharidosis type IIIB (MPS IIIB) is one of a group of lysosomal storage disorders that are characterised by the inability to breakdown heparan sulphate. In MPS IIIB, there is a deficiency in the enzyme alpha-N-acetylglucosaminidase (NAGLU) and early clinical symptoms include aggressive behaviour and hyperactivity followed by progressive mental retardation. The disease is autosomal recessive and the gene for NAGLU, which is situated on chromosome 17q21, is approximately 8.5 kb in length and contains six exons. Primers were designed to amplify the entire coding region and intron/exon boundaries of the NAGLU gene in 10 fragments. The PCR products were analysed for sequence changes using SSCP analysis and fluorescent DNA sequencing technology. Sixteen different putative mutations were detected in DNA from 14 MPS IIIB patients, 12 of which have not been found previously. The mutations include four deletions (219-237del19, 334-358del25, 1335delC, 2099delA), two insertions (1447-1448insT, 1932-1933insGCTAC), two nonsense mutations (R297X, R626X), and eight missense mutations (F48C, Y140C, R234C, W268R, P521L, R565W, L591P, E705K). In this study, the Y140C, R297X, and R626X mutations were all found in more than one patient and together accounted for 25% of mutant alleles.
IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution. (1994)

We have isolated a new human cDNA, named IFP 35, whose expression is regulated by interferons (IFN). Induction of IFP 35 mRNA in HeLa cells by IFN is due, at least in part, to increased transcription. In response to IFN treatment, the expression of IFP 35 mRNA is seen in a wide range of different cell types, including fibroblasts, macrophages, and epithelial cells. The cDNA sequence encodes a 282-amino acid protein with a deduced molecular mass of 31,130 Da. In vitro translation of mRNA obtained by both in vitro transcription and hybrid selection resulted in the synthesis of a 35-kDa protein. Antisera raised against IFP 35 recognized a protein with an apparent molecular mass of 35 kDa in HeLa cells. Amino acid sequence analysis revealed a leucine zipper motif in an alpha-helical configuration at the extreme amino terminus of IFP 35. Notable IFP 35 is a unique novel leucine zipper protein in that it lacks a basic domain critical for DNA binding. IFP 35 can specifically form homodimers in vitro. Western blot analysis of fractionated cell extracts indicates increased nuclear localization following IFN treatment.
The architecture of replica (1984)

REPLICA is a special-purpose computer architecture to support active multi-sensory perception of 3-D objects. The system is partitionable, reconfigurable, and highly parallel. In this paper, we present the design of a set of interconnection networks which form the core of the REPLICA architecture. This set of interconnection networks consists of a capability-enhanced cross-bar switch and multiple fast shift-register rings. The capability-enhanced cross-bar switch supports rapid set-up of partitions, point-to-point communication and broadcasting communication between the controller and processors in a partition. The multiple rings support high bandwidth communications among the processors and also provide the partitionability and reconfigurability required by the system. The cost of these interconnection networks can also be kept low. The communication delay in the ring network is analyzed by deriving an upper bound on the maximum communication delay in a partition. A set of performance attributes for evaluating the performance of reconfigurable, partitionable, and highly parallel computer systems is proposed. Based on this set of attributes, the design of the REPLICA architecture is evaluated and compared with the other reconfigurable, partitionable, and highly parallel computer architectures in the literature.
Low Voltage High Gain Linear Class Ab Cmos Ota With Dc Level Input Stage (2011)

This paper presents a low-voltage low-power differential linear transconductor with near rail-to-rail input swing. Based on the current-mirror OTA topology, the proposed transconductor combines the Flipped Voltage Follower (FVF) technique to linearize the transconductor behavior that leads to class- AB linear operation and the virtual transistor technique to lower the effective threshold voltages of the transistors which offers an advantage in terms of low supply requirement. Design of the OTA has been discussed. It operates at supply voltages of about ±0.8V. Simulation results for 0.18μm TSMC CMOS technology show a good input range of 1Vpp with a high DC gain of 81.53dB and a total harmonic distortion of -40dB at 1MHz for an input of 1Vpp. The main aim of this paper is to present and compare new OTA design with high transconductance, which has a potential to be used in low voltage applications.
Learning a similarity-based distance measure for image database organization from human partitionings of an image set (2002)

In this paper we employ human judgments of image similarity to improve the organization of an image database. We first derive a statistic, /spl kappa//sub B/ which measures the agreement between two partitionings of an image set. /spl kappa//sub B/ is used to assess agreement both amongst and between human and machine partitionings. This provides a rigorous means of choosing between competing image database organization systems, and of assessing the performance of such systems with respect to human judgments. Human partitionings of an image set are used to define a similarity value based on the frequency with which images are judged to be similar. When this measure is used to partition an image set using a clustering technique, the resultant partitioning agrees better with human partitionings than any of the feature-space-based techniques investigated. Finally, we investigate the use of multilayer perceptrons and a distance learning network to learn a mapping from feature space to this perceptual similarity space. The distance learning network is shown to learn a mapping which results in partitionings in excellent agreement with those produced by human subjects.
Soft-Chemistry of Garnet-Type Li<sub>5+<i>x</i></sub>Ba<sub><i>x</i></sub>La<sub>3–<i>x</i></sub>Nb<sub>2</sub>O<sub>12</sub> (<i>x</i> = 0, 0.5, 1): Reversible H<sup>+</sup> ↔ Li<sup>+</sup> Ion-Exchange Reaction and Their X-ray, <sup>7</sup>Li MAS NMR, IR, and AC Impedance Spectroscopy Characterization (2011)

Garnet-type Li5+xBaxLa3–xNb2O12 (x = 0, 0.5, 1) was prepared using the ceramic method. The H+/Li+ exchange was found to be most successful for x = 0, with ∼89% exchange, while x = 0.5 showed ∼46% exchange, and x = 1 showed ∼20% exchange in water at room temperature. For Li5La3Nb2O12, where more of the Li ions occupy tetrahedral sites (ca. 80%), the H+/Li+ exchange occurs readily. The population of octahedral-site Li ions increases as the amount of Li in Li5+xBaxLa3–xNb2O12 increases and the ion-exchange proceeds to a lesser extent in water at room temperature. The Li+/H+ ion-exchange of the proton-based garnet was found to be reversible, using 5 M LiNO3. The electrical conductivity of as-prepared Li5+xBaxLa3–xNb2O12, the proton-exchanged product, and reverse-ion-exchanged “Li5La3Nb2O12” were measured using AC impedance spectroscopy. The Li-ion conductivities of the reverse-ion-exchanged and as-prepared Li5La3Nb2O12 were found to exhibit comparable values and are consistent with literature reports. The proton-exchanged sample showed a moderate electrical conductivity of <10–6 S cm–1 at 125–250 °C, which may be attributed to the poor density of samples.
Rnr4p, a Novel Ribonucleotide Reductase Small-Subunit Protein (1997)

Ribonucleotide reductases catalyze the formation of deoxyribonucleotides by the reduction of the corresponding ribonucleotides. Eukaryotic ribonucleotide reductases are alpha2beta2 tetramers; each of the larger, alpha subunits possesses binding sites for substrate and allosteric effectors, and each of the smaller, beta subunits contains a binuclear iron complex. The iron complex interacts with a specific tyrosine residue to form a tyrosyl free radical which is essential for activity. Previous work has identified two genes in the yeast Saccharomyces cerevisiae, RNR1 and RNR3, that encode alpha subunits and one gene, RNR2, that encodes a beta subunit. Here we report the identification of a second gene from this yeast, RNR4, that encodes a protein with significant similarity to the beta-subunit proteins. The phenotype of rnr4 mutants is consistent with that expected for a defect in ribonucleotide reductase; rnr4 mutants are supersensitive to the ribonucleotide reductase inhibitor hydroxyurea and display an S-phase arrest at their restrictive temperature. rnr4 mutant extracts are deficient in ribonucleotide reductase activity, and this deficiency can be remedied by the addition of exogenous Rnr4p. As is the case for the other RNR genes, RNR4 is induced by agents that damage DNA. However, Rnr4p lacks a number of sequence elements thought to be essential for iron binding, and mutation of the critical tyrosine residue does not affect Rnr4p function. These results suggest that Rnr4p is catalytically inactive but, nonetheless, does play a role in the ribonucleotide reductase complex.
Antiproliferative effect of isopentenylated coumarins on several cancer cell lines. (2001)

33 coumarins, mainly the simple isopentenylated coumarins and derived pyrano- and furanocoumarins, were examined for their antiproliferative activity towards several cancer and normal human cell lines. The pyrano- and furanocoumarins showed strong activity against the cancer cell lines, whereas they had weak antiproliferative activity against the normal human cell lines. The decreasing rank order of potency was osthenone (10), clausarin (25), clausenidin (26), dentatin (24), nordentatin (23), imperatorin (29), seselin (27), xanthyletin (21), suberosin (17), phebalosin (8) and osthol (12). The structure-activity relationship established from the results revealed that the 1,1-dimethylallyl and isopentenyl groups have an important role for antiproliferative activity.
The City in History: Its Origins, Its Transformations, and Its Prospects (1961)

The city s development from ancient times to the modern age. Winner of the National Book Award. One of the major works of scholarship of the twentieth century (Christian Science Monitor). Index; illustrations.
Hole Blocking Layer-Free Perovskite Solar Cells with over 15% Efficiency (2017)

8th International Conference on Applied Energy, ICAE 2016, Beijing, China, 8-11 October 2016
Estimating the unseen (2011)

We introduce a new approach to characterizing the unobserved portion of a distribution, which provides sublinear--sample estimators achieving arbitrarily small additive constant error for a class of properties that includes entropy and distribution support size. Additionally, we show new matching lower bounds. Together, this settles the longstanding question of the sample complexities of these estimation problems, up to constant factors. Our algorithm estimates these properties up to an arbitrarily small additive constant, using O(n/log n) samples, where n is a bound on the support size, or in the case of estimating the support size, 1/n is a lower bound on the probability of any element of the domain. Previously, no explicit sublinear--sample algorithms for either of these problems were known. Our algorithm is also computationally extremely efficient, running in time linear in the number of samples used.
Discovery and Preclinical Studies of (<i>R</i>)-1-(4-(4-Fluoro-2-methyl-1<i>H</i>-indol-5-yloxy)-5- methylpyrrolo[2,1-<i>f</i>][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an In Vivo Active Potent VEGFR-2 Inhibitor (2006)

A series of substituted 4-(4-fluoro-1H-indol-5-yloxy)pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of vascular endothelial growth factor receptor-2 kinase is reported. Structure-activity relationship studies revealed that a methyl group at the 5-position and a substituted alkoxy group at the 6-position of the pyrrolo[2,1-f][1,2,4]triazine core gave potent compounds. Biochemical potency, kinase selectivity, and pharmacokinetics of the series were optimized and in vitro safety liabilities were minimized to afford BMS-540215 (12), which demonstrated robust preclinical in vivo activity in human tumor xenograft models. The l-alanine prodrug of 12, BMS-582664 (21), is currently under evaluation in clinical trials for the treatment of solid tumors.
Lactobacilli isolated from kefir grains: evidence of the presence of S-layer proteins (2004)

In the present study we report for the first time the presence of S-layer proteins in Lactobacillus kefir and Lactobacillus parakefir isolated from kefir grains. Soluble whole-cell protein profile obtained either by mechanical disruption (X-press) or by a combined treatment with lysozyme and SDS on whole cells, showed a significant band of apparent molecular mass of 66-71 kDa as measured by SDS-PAGE. The intensity of this band was considerably reduced when cells were treated with 5 M-LiCl. The above mentioned proteins were recovered in the LiCl extracts. After dialysis and concentration, the proteins extracted were able to reassemble in a regular array. Negative staining of these protein preparations were analysed by transmission electron microscopy and a paracrystalline arrangement was seen. Thin sections of bacteria analysed by transmission electron micrographs showed an outermost layer over the bacterial cell wall, that was lost after the LiCl treatment. The production of this surface structure under different culture conditions was also evaluated. Finally, the relationship between the presence of S-layer proteins and surface properties (e.g. adhesion to Caco-2 cells, autoaggregation, and hemagglutination) was investigated.
Templateassisted selfassembly of macro–micro bifunctional porous materials (2001)

The preparation of macro–micro bifunctional porous materials has been accomplished by a well-controlled, vacuum-assisted technique. Monodisperse polystyrene latex spheres were ordered into close-packed arrays by slow sedimentation, allowing a high flux of water through the interstices between latex spheres. Zeolite LTA, FAU, LTL, BEA, MFI and Si-MFI nanocrystals, synthesized by hydrothermal procedures, permeated the interstices of latex spheres under the driving force of flowing water. After drying and calcination at 500 °C, both the latex spheres and zeolite structure-directing molecules were removed, followed by the formation of products consisting of both crystalline micropores and periodic, interconnected networks of submicron macropores. XRD, SEM, TEM, IR, TG/DTA, ICP and N2 adsorption–desorption measurements were performed to monitor the preparation and to characterize the properties of the macro–micro bifunctional porous materials. The materials presented in this paper combine the benefits of both the micropore and macropore regimes. They could potentially improve the efficiency of both separation and catalysis of zeolites.
Reduction of Endogenous GRP78 Levels Improves Secretion of a Heterologous Protein in CHO Cells (1988)

GRP78 is localized in the endoplasmic reticulum and associates with improperly folded or underglycosylated proteins. The role of GRP78 in secretion was studied in Chinese hamster ovary cells expressing a tissue plasminogen activator (tPA) variant which lacks potential N-linked glycosylation site sequences because of mutagenesis. The expression of variant tPA resulted in elevated levels of GRP78 and its stable association with tPA. The introduction of antisense GRP78 genes resulted in a two- to threefold reduction in GRP78 levels compared with those of the original cells. Cells with reduced levels of GRP78 secreted two- to threefold-higher levels of tPA activity. tPA expressed in these cells displayed reduced association with GRP78, and a greater proportion was processed to the mature form and secreted. These results demonstrate that reduction of GRP78 level can improve the secretion of an associated protein.
Addition of Ethyl Tribromoacetate to Butadiene Induced by Ultraviolet Radiation (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition of Ethyl Tribromoacetate to Butadiene Induced by Ultraviolet RadiationMarilyn F. Leto and Catherine S. Hsia ChenCite this: J. Org. Chem. 1962, 27, 10, 3708–3710Publication Date (Print):October 1, 1962Publication History Published online1 May 2002Published inissue 1 October 1962https://doi.org/10.1021/jo01057a522RIGHTS & PERMISSIONSArticle Views36Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (349 KB) Get e-Alerts Get e-Alerts
Routing subject to quality of service constraints in integrated communication networks (1995)

With increasingly diverse QOS requirements, it is impractical to continue to rely on conventional routing paradigms that emphasize the search for an optimal path based on a predetermined metric, or a particular function of multiple metrics. Modern routing strategies must not only be adaptive to network changes but also offer considerable economy of scope. We consider the problem of routing in networks subject to QOS constraints. After providing an overview of prior routing work, we define various QOS constraints. We present a call architecture that may be used for QOS matching and a connection management mechanism for network resource allocation. We discuss fallback routing, and review some existing routing frameworks. We also present a new rule-based, call-by-call source routing strategy for integrated communication networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>