gebhart/patrepeval huggingface dataset:
An infrastructure for web-agent-based service providing (1997)

. Mobile agents are a new paradigm in distributed computing. In this paper we describe a platform, which supports Web agents --- mobile agents that live in web servers and communicate with users through web browsers. Our belief is that this World Wide Web scenario identifies an application area for which the mobile agent abstraction which is well-suited. We present the state of implementation, and we give an outlook on our future work. Keywords: mobile agents, service providing, World Wide Web, security, infrastructure, mobile agents application 1 Introduction `Mobile Agents&apos; are programs that can move from computer to computer to fulfill a task on behalf a user. To overcome the problem of heterogeneity, mobile agents are mostly programmed in an interpreted language for which an interpreter is available for a wide range of computer systems. Using an interpreted language also solves, to a certain extent, one of the most important problems for mobile agent systems: security. Since the i...
The critical role of Krüppel-like factors in kidney disease (2016)

Krüppel-like factors (KLFs) are a family of zinc-finger transcription factors critical to mammalian embryonic development, regeneration, and human disease. There is emerging evidence that KLFs play a vital role in key physiological processes in the kidney, ranging from maintenance of glomerular filtration barrier to tubulointerstitial inflammation to progression of kidney fibrosis. Seventeen members of the KLF family have been identified, and several have been well characterized in the kidney. Although they may share some overlap in their downstream targets, their structure and function remain distinct. This review highlights our current knowledge of KLFs in the kidney, which includes their pattern of expression and their function in regulating key biological processes. We will also critically examine the currently available literature on KLFs in the kidney and offer some key areas in need of further investigation.
Flow noise reduction techniques for a planar array of hydrophones (1992)

This paper presents techniques for reducing turbulent boundary layer pressure fluctuations using wave-number filters. Reduction of flow noise can be achieved by filtering wave numbers using a finite hydrophone or an array of hydrophones, or by filtering wave numbers using a layer of elastomer. The baseline turbulent wall pressure spectrum that represents the flow excitation function is based on the Corcos model modified to fit a realistic estimate at the low wave-number region. The occurrence of the convective ridge wave number is estimated by using a convective flow speed that is a function of frequency. Major results presented are numerically calculated noise reductions compared to the calculated noise level for a flush-mounted point hydrophone.
Named Data Networking of Things (Invited Paper) (2016)

The Internet of Things (IoT) is a vision for interconnecting all of the world's "things" -- from vehicles to diet scales, smart homes and electrical grids -- through a common set of networking technologies. Realizing this vision using a host-to-host communication paradigm, such as that of the Internet Protocol (IP), is challenging in the context of highly heterogeneous, constrained devices that connect intermittently to one or more networks, often using multiple interfaces, communicate within various security regimes, and require both local and global communication capability. Using IP and similar protocols as the narrow waist of interoperability for IoT requires managing data exchange and security in terms that are largely orthogonal to application semantics, while simultaneously needing to minimize resource usage. This paper explores how Named Data Networking (NDN), a proposed future Internet architecture, addresses the root causes of these challenges and can help achieve the IoT vision in a more secure, straightforward, and innovation-friendly manner. NDN's data-centric communication model aligns network and application semantics, enabling developers to work with "things" and their data directly, and for IoT networks to be deployed and configured easily. To substantiate the high-level discussion, we give examples of ongoing design and implementation work in IoT over NDN and compare the architecture to well-known existing protocols and frameworks. Finally, we discuss short-and long-term scenarios for employing NDN to enable the Internet of Things.
What is cryptography? (2006)

Cryptography's aim is to construct schemes or protocols that can still accomplish certain tasks even in the presence of an adversary. A basic task in cryptography is to enable users to communicate securely over an insecure channel in a way that guarantees their transmissions' privacy and authenticity. Providing privacy and authenticity remains a central goal for cryptographic protocols, but the field has expanded to encompass many others, including e-voting, digital coins, and secure auctions. This paper explains what cryptography is about and how we can scientifically justify a cryptographic scheme's security.
Droplet formation at megahertz frequency (2016)

Droplet formation has been a fascinating subject to scientists for centuries due to its natural beauty and importance to both scientific and industrial applications, such as inkjet printing, reagent deposition, and spray cooling. However, the droplet generation frequency of common drop‐on‐demand (DOD) jetting techniques is mostly limited to ∼10 kHz. This article presents an investigation of the possibility of jetting at megahertz frequencies to boost the productivity of DOD material deposition by ∼100 times. The focus of this article is to understand the limitations of generating droplets at a megahertz frequency and to explore possible solutions for overcoming these limitations. A numerical model is first developed for the simulation of droplet formation dynamics. The numerical model is validated against available experimental data from the literature. Aided by insights gained from scaling analysis, the validated model is then used to study the effects of different parameters on high frequency jetting. The study finds energy density input to the nozzle is the key to achieve megahertz frequency droplet breakup. © 2016 American Institute of Chemical Engineers AIChE J , 63: 2367–2377, 2017
Identification of LEM-14 inhibitor of the oncoprotein NSD2 (2018)

The NSD family (NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1) are histone lysine methyltransferases (HMTases) essential for chromatin regulation. The NSDs are oncoproteins, drivers of a number of tumors and are considered important drug-targets but the lack of potent and selective inhibitors hampers further therapeutic development and limits exploration of their biology. In particular, MMSET/NSD2 selective inhibition is being pursued for therapeutic interventions against multiple myeloma (MM) cases, especially in multiple myeloma t(4;14)(p16.3;q32) translocation that is associated with a significantly worse prognosis than other MM subgroups. Multiple myeloma is the second most common hematological malignancy, after non-Hodgkin lymphoma and remains an incurable malignancy. Here we report the discovery of LEM-14, an NSD2 specific inhibitor with an in vitro IC<sub>50</sub> of 132 μM and that is inactive against the closely related NSD1 and NSD3. LEM-14-1189, a LEM-14 derivative, differentially inhibits the NSDs with in vitro IC<sub>50</sub> of 418 μM (NSD1), IC<sub>50</sub> of 111 μM (NSD2) and IC<sub>50</sub> of 60 μM (NSD3). We propose LEM-14 and derivative LEM-14-1189 as tools for studying the biology of the NSDs and constitute meaningful steps toward potent NSDs therapeutic inhibitors.
Steam pressure processing of milo for growing-finishing pigs (1967)

Two trials, using a total of 40 pigs to compare ground milo with milo processed at 20 psi steam pressure for 11/2 minutes before grinding, showed no significant differences in rate of gain, feed conversion, or carcass characteristics.
Transfection of wild-type deoxycytidine kinase (dck) cDNA into an AraC- and DAC-resistant rat leukemic cell line of clonal origin fully restores drug sensitivity (1995)

The AraC-resistant rat leukemic cell line RO/1-A has been shown to have a typical deoxycytidine kinase (DCK)-deficient phenotype and cannot metabolize the antileukemic drugs cytarabine (AraC) and decitabine (DAC). To investigate the relative contribution of mutations in the dck gene to the development of in vitro-induced AraC-resistance, a neomycin selectable plasmid construct harboring the wild-type dck coding region was transfected into RO/1-A. Polymerase chain reaction analysis confirmed the presence of vector DNA in the target cells (RO/1-ADCK) that were stably transfected and monitored over a period of 14 weeks. Northern and Western blot analysis showed restoration of dck mRNA and protein expression. Initial rate measurements of DCK activity showed that Km values for dck were only slightly altered as a result of transfection, whereas strongly increased Vmax values were observed, resulting in a 12-fold increased phosphorylation efficiency for both dC and AraC, compared with the AraC-sensitive parental cell line RO/1 from which the RO/1-A was originally derived. In vitro sensitivity to AraC- and DAC-mediated cytotoxicity was fully restored in RO/1-ADCK. The data pinpoint acquired DCK deficiency caused by mutations of the dck gene as the major cause of AraC resistance in this model.
Ly-1 (CD5), a membrane glycoprotein of mouse T lymphocytes and a subset of B cells, is a natural ligand of the B cell surface protein Lyb-2 (CD72) (1992)

CD5 is a 67-kDa glycoprotein expressed on the cell surface membrane of all T lymphocytes and on a small proportion of B lymphocytes. The physiologic role of this Ag is still unknown. Structural and functional studies of CD5 suggest that it might act as a receptor for a positive signal. CD5-specific mAb augment CD3- or mitogen-induced T cell proliferation, IL-2 secretion, and IL-2R expression and induce a rise in intracellular [Ca2+]. In this report, we describe the purification of mouse CD5 protein (mCD5) and its use as a probe to search for the ligand of CD5. We demonstrate that mCD5 specifically interacts with the mouse B cell differentiation Ag CD72/Lyb-2. Three serologically defined allelic forms of mouse CD72/Lyb-2 can all interact with mCD5. We further show that mCD5 can interact with human CD72/Lyb-2, and similarly, that human CD5 can interact with mouse CD72/Lyb-2. These studies may have major implications for the mechanisms of T-B cell communication.
On-board 22 kW fast charger &#x201C;NLG6&#x201D; (2013)

With NLG6, BRUSA enters a new dimension of charging! BRUSA Elektronik AG is the first company to produce a battery charger for electric vehicles that is capable of operating on a three-phase current with a power of up to 22 kW. Thereby, the fast charger will be able to fully charge a typical electric car in less than one hour, this is six time faster than the former technology (one-phase with 3.3 kW). Cars from a major European car manufacturer equipped with this charger are already available; other manufacturers have started the evaluation of the new charger in their vehicles [7]. It can be expected that the immense reduction of the charging time will influence the acceptance of e-mobility, as the charging time now corresponds to the duration of a shopping visit or just the time for taking a meal.
Scalp Flaps in the Treatment of Baldness (1996)

Scalp flaps, when performed properly with anticipation of further hair loss, are an effective treatment of male pattern baldness in the appropriately selected patient.
Nucleotide sequence, chromosomal localization and developmental expression of the mouse<i>int-1</i>-related gene (1989)

cDNA clones encoding the murine int-1-related protein (m-irp) were isolated from an 8.5-day mouse embryo library. m-irp and its human counterpart, h-irp, share extensive nucleotide homology in coding (92%) and 3' untranslated (69%) regions. At the amino acid level, m-irp and h-irp share 97% of amino acids including all 24 cysteine residues, which are highly conserved among members of the int-1 family. However, in contrast to h-irp and int-1, the predicted m-irp protein sequence did not contain a signal peptide sequence. Analysis of polymerase chain reaction, amplified cDNA, and genomic sequences strongly suggests that a single-base substitution has created a new 5' splice site 17 bp 5' of a highly conserved splice site. Splicing at this new site generates a mRNA-encoding an amino-terminal truncated protein. Splicing at the conserved splice site generates a mRNA species encoding a protein with a signal peptide sequence similar to h-irp. Close linkage between m-irp and the met oncogene maps m-irp sequences to proximal mouse chromosome 6. Adult and fetal expression of m-irp was examined by RNA blot analysis. Adult expression of m-irp is restricted to lungs and heart, and fetal expression, to placental tissue and to all stages of fetal development examined. In situ hybridization localized early fetal m-irp expression to the pericardium of the heart, to the umbilicus and associated allantoic mesoderm, and to the ventral lateral mesenchyme tissue surrounding the umbilical vein in the fetus. These results suggest a role for m-irp in the development of fetal allantoic communication.
Voltage instability: mechanisms and control strategies [power systems] (1995)

One of the main objectives in operating an electric power system is to maintain a proper voltage level throughout the system. Failure to do so can lead to equipment damage and blackouts. The article discusses the nonlinear aspects of power systems, with emphasis on voltage instability. It provides an overview of the state-of-the-art on the analysis and control of voltage dynamics. Dynamic mechanisms and control strategies are discussed from both theoretical and practical standpoints. The remedial controls implemented in the Puget Sound region of the Pacific Northwest indicate the practical significance of the research area.
Synergistic profiles of chain‐breaking antioxidants with phosphites and hindered amine light stabilizers in styrene–ethylene–butadiene–styrene (SEBS) block copolymer (2006)

Abstract The photostabilization of poly(styrene‐ b ‐ethylene‐ co ‐butylene‐ b ‐styrene) (SEBS) by phosphite/ p ‐hydroxybenzoate antioxidants and hindered phenol/hindered amine light stabilizers (HALS) was studied by using a variety of spectroscopic methods, including FTIR, UV, and luminescence spectroscopy coupled with crosslinking and hydroperoxide analysis. The results were compared with those obtained for hindered phenols and their combinations with phosphite antioxidants. All the stabilizing packages stabilized the SEBS in terms of the inhibition of discoloration and the formation of hydroperoxides, acetophenone, and oxidation products, as well as chain scission and disaggregation of the styrene units. Although phosphite/ p ‐hydroxybenzoate combinations appeared to reduce the formation of oxidation products, they did not show any remarkable enhancement in long‐term stabilization with respect to phenolic/phosphite antioxidants. On the other hand, strong synergistic profiles were found with the HALS. Mobility and diffusion impediments in the polymeric material appeared to play an important role in the stabilizing activity of the HALS. J. VINYL. ADDIT. TECHNOL. 12:8–13, 2006. © 2006 Society of Plastics Engineers
Genomic Imprinting of <i>Dopa decarboxylase</i> in Heart and Reciprocal Allelic Expression with Neighboring <i>Grb10</i> (2007)

By combining a tissue-specific microarray screen with mouse uniparental duplications, we have identified a novel imprinted gene, Dopa decarboxylase (Ddc), on chromosome 11. Ddc_exon1a is a 2-kb transcript variant that initiates from an alternative first exon in intron 1 of the canonical Ddc transcript and is paternally expressed in trabecular cardiomyocytes of the embryonic and neonatal heart. Ddc displays tight conserved linkage with the maternally expressed and methylated Grb10 gene, suggesting that these reciprocally imprinted genes may be coordinately regulated. In Dnmt3L mutant embryos that lack maternal germ line methylation imprints, we show that Ddc is overexpressed and Grb10 is silenced. Their imprinting is therefore dependent on maternal germ line methylation, but the mechanism at Ddc does not appear to involve differential methylation of the Ddc_exon1a promoter region and may instead be provided by the oocyte mark at Grb10. Our analysis of Ddc redefines the imprinted Grb10 domain on mouse proximal chromosome 11 and identifies Ddc_exon1a as the first example of a heart-specific imprinted gene.
Speech Recognition and Spoken Language Understanding for Mobile Personal Assistants: A Case Study of &#x0022;Shabette Concier&#x0022; (2013)

Recent success of mobile personal assistants deeply relies on the advancement in statistical automatic speech recognition (ASR) and spoken language understanding (SLU) technologies. This article describes practical design of ASR and SLU systems for "Shabette Concier", a voice-based personal assistant application commercially released by NTT docomo in Japan in March 2012. Utilization of a large amount of field speech data gathered from the actual service is focused and the potential of big data is discussed.
Click Modulation (1984)

In this paper we show how one may determine a sequence of equal intensity impulses or clicks <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$$\pi \sum^{\infty}_{-\infty} \delta (t-t_k)$$</tex> such that a desired bandpass signal, f'(t), may be obtained by filtering the clicks; i.e. <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$$f^{'}(t) = \pi \sum^{\infty}_{-\infty} K(t-t_k),$$</tex> where K(t) is the impulse response of a suitable bandpass filter. The {t <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</inf> } are found as the zeros of a bandlimited signal s(t), where if f(t), the bandpass signal whose derivative is f'(t), is sufficiently small, we also have <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$$f(t) = \int^{\infty}_{-\infty} q(x)K(t-x)dx,$$</tex> where q(x) is a square wave simply related to s(t).
Two-Step Desorption Process of Au Nanoparticles in D<sub>2</sub>O Suspension on Amino-Terminated SiO<sub>2</sub>/Si Substrate Induced by Small Thiol Molecules (2007)

We investigated the desorption process of Au nanoparticles immobilized on an amino-terminated SiO2/Si surface in a D2O environment by in situ attenuated total reflection surface enhanced infrared absorption spectroscopy. The advantages of IR spectroscopy over other methods were demonstrated; the IR spectra are not only sensitive to the changing particle density at the surface, but also to chemical environmental changes. Therefore, the gained information obtained by IR spectroscopy and scanning electron microscopy allows us to propose a microscopic model for the desorption process of the Au nanoparticles from the substrate.
Current issues in developing a strategy for dealing with the acquired immunodeficiency syndrome. (1986)

A number of current issues exist that must be taken into account in the development of a strategy for dealing with the problem of the acquired immunodeficiency syndrome (AIDS) in the United States and throughout the world. Given the complexity of the problem and the fact that the epidemic is still in its evolving stages, such issues must be considered individually and as a group. The present discussion focuses on several of these critical issues and outlines approaches that might be useful in the formulation of basic scientific and public health strategies for dealing with the currently appreciated and projected problems in AIDS.
Induced optical aberrations following formation of a laser in situ keratomileusis flap (2002)

Flap formation during LASIK can modify the eye's existing natural higher-order aberrations (especially spherical and coma-like aberrations along the axis of the flap's hinge), while visual acuity and refractive error remain unaffected.
<title>Application of liquid-crystal-display modeling to improve the optical performance of LCD panels (Invited Paper)</title> (1992)

Modeling of a liquid crystal display (LCD) includes two parts: one is the calculation of the LC director deformation profile inside the cell the other is the LCD optics computation. For the LC director deformation profile calculation, it is usually assumed all the LC molecules within a pixel respond together uniformly to a driving voltage. This one-dimensional (1-D) simulation is a good approximation for most cases. However, due to the finite size of the pixel, the pixel fringe field may drive the LC molecules near the pixel edge to tilt in a direction different from those in the center of the pixel. To understand the detailed LC director structures inside the pixel and their effect on the display performances (especially for the small sized pixel), the two-dimensional (2-D) or sometimes three dimensional (3-D) simulation is required. The 1-D, 2-D and 3-D simulations of the LC director deformation profile will be discussed. For the LCD optics, besides the 4 X 4 matrix method, another alternative method will also be discussed. Finally, examples using the 1-D, 2-D and 3-D LCD simulations to improve the display optical performances will be illustrated.
Characterization of genetic defects of hemophilia A in patients of Chinese origin. (1993)

The molecular characterization of hemophilia A of Chinese origin was carried out by the polymerase chain reaction (PCR) and direct sequencing of patients' factor VIII genes. Single-strand conformation polymorphism (SSCP) and dideoxy fingerprinting (ddF) were used as screening methods to detect mutated DNAs. A total of 102 individuals from 87 different families, including 10 patients (10 families) with mild-to-moderate and 92 patients (77 families) with severe hemophilia A, were analyzed by PCR-SSCP and PCR-ddF. Of the 87 independent cases, 40 revealed a single mutation in the coding regions of their factor VIII genes. These mutations include 21 with single base changes resulting in 8 nonsense and 13 missense codons, 16 with deletion or insertion of 1-11 nucleotides, and 3 with deletion of large DNA fragments. The frequency of 8 of the identified factor VIII polymorphisms or silent mutations was also determined among Chinese. The frequencies for codons 1241, 1269, and 2223 (the numbering system follows J. Gitschier et al., 1984, Nature 312: 326-330) were found to be different from those reported for other populations. As for the 47 severe cases whose mutational events were not readily detected by PCR-SSCP and PCR-ddF, the reverse transcriptase PCR method was applied. In 24 such cases analyzed, 17 were found to be of the "intron 22 mutations" as described by Naylor et al. (1992, The Lancet, 342: 1066-1067), accounting for 39% of Chinese patients with hemophilia A.
Mapping the fine specificity of a cytolytic T cell response to HIV-1 <i>nef</i> protein. (1990)

Epitope mapping of a MHC class I-restricted cytotoxic T cell response to nef, a regulatory protein of HIV, was performed with fresh PBMC from HIV-seropositive donors and target cells pulsed with a panel of overlapping peptides of the nef protein. These nef-specific CTL recognized a synthetic peptide of 10 residues derived from a nonamphipathic, highly conserved region of the nef protein in association with the HLA A3.1 molecule. Using human cell transfectants expressing mutations of the A3 molecule, we demonstrated that the amino acid at position 152 of the A3.1 molecule appears to be critical for detection of this response. Thus, rapid analysis of the epitopes of HIV proteins stimulating CTL responses can be achieved using a combination of fresh donor PBMC and target cells pulsed with synthesized peptides.