gebhart/patrepeval huggingface dataset:
Induction of sensitivity to the cytotoxic action of tumor necrosis factor alpha by adenovirus E1A is independent of transformation and transcriptional activation (1990)

We have previously shown that expression of the adenovirus E1A 12S or 13S products in NIH 3T3 fibroblasts induces susceptibility to the cytotoxic actions of tumor necrosis factor alpha (TNF alpha). A large number of studies have mapped the multiple biological functions of the 12S and 13S products to three highly conserved regions (CR) within the E1A sequence. Here we used plasmids coding for E1A deletion and point mutants in these regions to generate target cell lines for TNF alpha cytotoxicity assays to determine which regions and functions are necessary for the induction of TNF alpha sensitivity. Expression of CR1 was required for the induction of TNF alpha sensitivity. This finding did not reflect a requirement for transforming or transcriptional repression activity, since some mutants that were defective in both of these properties were able to induce TNF alpha sensitivity. CR2 transformation-defective point mutants, but not a CR2/3 region deletion mutant, were also able to induce sensitivity. In addition, NIH 3T3 cells expressing the retroviral transcription activators tat from human immunodeficiency virus type 1 and tax from human T-lymphotropic virus type I were not sensitive to TNF alpha. However, the possibility that E1A-mediated transcriptional activation can augment the induction of TNF alpha sensitivity is not excluded. Comparison of data from previous biological studies with the TNF alpha cytotoxicity assays presented here suggested that the mechanism by which E1A induces sensitivity to TNF alpha in NIH 3T3 cells is independent of many of the known E1A biological functions, including transformation in cooperation with ras, immortalization, induction of DNA synthesis in quiescent cells, and transcriptional repression. A novel E1A-mediated effect may be involved, although our data do not exclude the possibility that sensitization to TNF alpha is mediated through E1A binding to cellular proteins.
A Flexible Architecture for Feature-Based Image Editing (2006)

This paper presents a scheme for feature-based image editing. In the proposed method, an image is decomposed into a skeleton component and a residual component. The skeleton component is obtained by performing iterative linear interpolation based on high-curvature points, which are extracted from the image surface using a Hessian tensor. The residual component is obtained by subtracting the skeleton component from the original image. By manipulating the skeleton component and the residual component, several applications, such as adaptive contrast enhancement, sharpness enhancement, and shape editing, can be achieved. Experimental results are provided to verify the versatility and flexibility of this proposed architecture.
Evaluation of Compound Interference in Immobilized Metal Ion Affinity-Based Fluorescence Polarization Detection with a Four Million Member Compound Collection (2003)

IMAP is a non-separation-based, antibody-independent, FP assay that can be applied to many types of protein kinases and phosphatases. This technology is currently being used in many high-throughput screening campaigns throughout the industry. In this technology, a fluorescently labeled peptide substrate is phosphorylated and then captured on immobilized metal (M(III)) nanoparticles, an interaction that is enhanced at low pH (pH 5.5). The binding of the phosphorylated peptide to the nanoparticles is detected using FP. IMAP differs from other FP formats in that the polarization signal is antibody-independent and involves metal coordination complexes detected at low pH. Here, this technology is evaluated against a 4000000-member compound collection using a 1536-well assay design that is devoid of enzymes so that only interference of the compounds with the detection system is measured. Miniaturization of the assay to 1536-well plates is discussed. Compound interference due to inhibition of phosphopeptide binding to the M(III) nanoparticles is not observed. Additionally, it is concluded that the level of fluorescence compound interference is similar to typical FP formats for the majority of the compound collection.
High-Dose Ketoconazole Therapy in Patients with Metastatic Prostate Cancer (1986)

High-dose ketoconazole, 400 mg orally every 8 h, was administered in two groups of patients with metastatic prostate cancer. Group A consisted of 10 patients who had not undergone orchiectomy and Group B, eight patients who had orchiectomy prior to the study. Significant declines in testosterone, androstenedione, and dehydroepiandrosterone levels, reciprocal elevation of the gonadotropin levels (FSH and LH), and a persistent fall in serum acid phosphatase levels were observed in Group A patients. Three Group A patients achieved a partial objective remission (duration 9, 41 +, and 69 weeks); four patients, stabilization of their disease for a median of 33.5 weeks (range 16–40+ weeks); and two progressed (The National Prostatic Cancer Project Criteria). Stable disease in two Group B patients (7 and 20 weeks) and progression in four patients were observed. Gastrointestinal irritation was the main toxicity and was similar in both groups. Two Group A patients developed symptomatology consistent with adrenal insufficiency. Ketoconazole can suppress androgen production and has a beneficial role in the hormonal therapy of patients with prostate cancer who have not undergone orchiectomy.
Sediment Porewater Partitioning of Polycyclic Aromatic Hydrocarbons in Three Cores from Boston Harbor, Massachusetts (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSediment Porewater Partitioning of Polycyclic Aromatic Hydrocarbons in Three Cores from Boston Harbor, MassachusettsSusan E. McGroddy and John W. FarringtonCite this: Environ. Sci. Technol. 1995, 29, 6, 1542–1550Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/es00006a016https://doi.org/10.1021/es00006a016research-articleACS PublicationsRequest reuse permissionsArticle Views768Altmetric-Citations259LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spectral mismatch due to preemphasis in LPC analysis/Synthesis (1980)

The standard first-order preemphasis approach used in linear prediction analysis results in an undesirable low-frequency boost in the synthesis spectrum. A solution is obtained by mismatching the preemphasis and postemphasis factors or by using a particular second-order preemphasis filter.
Comparison of Tissue Injury from Focused Ultrasonic Propulsion of Kidney Stones Versus Extracorporeal Shock Wave Lithotripsy (2013)

Focused ultrasonic propulsion produced no detectable morphological injury to the renal parenchyma when using clinical treatment parameters but produced injury comparable in size to that of extracorporeal shock wave lithotripsy when using excessive treatment parameters.
Inversion-Type Enhancement-Mode InP Mosfets with ALD High-K Al2O3 and HFO2 as Gate Dielectrics (2008)

Enhancement-mode (E-mode) n-channel InP metal-oxide-semiconductor field-effect-transistors (MOSFETs) with 0.75 to 40 mum gate length fabricated on semi-insulating substrates and p-type doped InP epi-layers with atomic-layer-deposited (ALD) Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> and HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> as gate dielectrics are demonstrated. The ALD process on III-V compound semiconductors enables the formation of high- quality gate oxides and unpinning of Fermi-level on compound semiconductors. A 1-mum gate-length E-mode n- channel MOSFET with a HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gate oxide thickness of 10 nm shows a maximum drain current of 130 mA/mm and a trans- conductance of 40 mS/mm at the highest gate bias of 6 V.
Recognition and Classification of Human Behavior in Intelligent Surveillance Systems using Hidden Markov Model (2015)

Shadows are physical phenomena that appear on a surface when direct light from a source is unable to reach the surface due to the presence of an object between the source and the surface. The formation of shadows and their various features has evolved as a topic of discussion among researchers. Though the presence of shadows can aid us in understanding the scene model, it might impair the performance of applications such as object detection. Hence, the removal of shadows from videos and images is required for the faultless working of certain image processing tasks. This paper presents a survey of notable shadow removal techniques for single image available in the literature. For the purpose of the survey, the various shadow removal algorithms are classified under five categories, namely, reintegration methods, relighting methods, patch-based methods, color transfer methods, and interactive methods. Comparative study of qualitative and quantitative performances of these works is also included. The pros and cons of various approaches are highlighted. The survey concludes with the following observations-(i) shadow removal should be performed in real time since it is usually considered as a preprocessing task, (ii) the texture and color information of the regions underlying the shadow must be recovered, (iii) there should be no hard transition between shadow and nonshadow regions after removing the shadows.
Direct method for TDS stability analysis (1987)

A direct approach to the analysis of systems with single, or commensurate delays is presented, and compared with other recently proposed methods. The finite polynomials arising in this direct method are shown to have useful sensitivity properties. Remarks are given concerning systems stable independent of delay.
Experimental Organic Chemistry (1986)

Experimental organic chemistry , Experimental organic chemistry , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
INITIATION VIA HALOBORATION IN LIVING CATIONIC POLYMERIZATION. 6. A NOVEL METHOD FOR THE SYNTHESIS OF PRIMARY AMINE FUNCTIONAL POLYISOBUTYLENES (1999)

Polyisobutylene (PIB) benzyl amine was synthesized by reacting benzyl azide with the dichloroboron head group of PIB obtained by polymerization of isobutylene (IB) via haloboration-initia-tion with boron trichloride. The facile, one-pot reaction at room temperature resulted in quantitative conversion of the PIB dichloroboron head groups into benzyl amine functionality, determined by 1H NMR spectroscopy and titration with per-chloric acid. The hydrogenation of the secondary amine was attempted with various hydrogenation catalysts, of which only palladium yielded primary amine functional PIB. Pt and PtO hydrogenated the benzene ring resulting in PIB cyclohexyl methylene amine. With Pd only about 80% of the chain ends carried the primary amine functional group, apparently due to a side reaction. The side reaction was studied by 1H NMR spectroscopy using PIB benzyl amine prepared from deuterated IB. Although direct evidence was not obtained, the 1H NMR spectrum of the debenzylated product indicates that elimination of the amine group from the α carbon and elimination of a methyl group from the β carbon take place simultaneously, presumably due to the crowded nature of the neopentyl-type structure. The primary amine functional PIB was converted into PIB acetyl amide and imide via acylation with acetyl chloride. The products were analyzed by IR, 1H NMR, and 13C NMR spectroscopy.
Cellular imunity in neoplasia: <i>Antigen and mitogen responses in patients with bronchiogenic carcinoma</i> (1975)

Cellular immune responses of patients with histologically confirmed lung carcinoma were assessed in vivo using cutaneous response and in vitro with a microlymphocyte blastogenic transformation (LBT) assay. In addition, correlation of the cutaneous response with the migration inhibitory factor (MIF) assay and LBT response was examined. The results indicated that cutaneous responses seen in patients with cancer of the lung were consistently lower than similar responses in normal controls (p less than 0.001). Similarily, the percentage of positive cutaneous responses seen with patients included in this study was lower than the frequencies reported by others. Stimulation of cells from lung cancer patients by PHA-M was also depressed when compared to similar lymphocytic responses in normal volunteers (p less than 0.001). The correlation between cutaneous response to tuberculin and the in vitro assays was high. The few instances of disparity demonstrate the need to utilize more than one assay in evaluating cellular immune functions. These data would support the work of others that indicate a depression of cellular immunity in advanced malignancy.
Stated Choice Methods (2000)

Understanding and predicting the behaviour of decision makers when choosing among discrete goods has been one of the most fruitful areas of applied research over the last thirty years. An understanding of individual consumer behaviour can lead to significant changes in product or service design, pricing strategy, distribution channel and communication strategy selection, as well as public welfare analysis. This graduate and practitioner guide, first published in 2000, deals with the study and prediction of consumer choice behaviour, concentrating on stated preference (SP) methods - placing decision makers in controlled experiments that yield hypothetical choices - rather than revealed preferences (RP) - actual choices in the market. It shows how SP methods can be implemented, from experimental design to econometric modelling, and suggests how to combine RP and SP data to get the best from each type. The book also presents an update of econometric approaches to choice modelling.
GPS time synchronization system for K2K (2000)

The K2K (KEK E362) long-baseline neutrino oscillations experiment requires synchronization of clocks with 100 nsec accuracy at the near and far detector sites (KEK and Super-Kamiokande, respectively), which are separated by 250 km. The Global Positioning System (GPS) provides a means for satisfying this requirement at very low cost. In addition to low-resolution time data (day of year, hour, minute, second), commercial GPS receivers output a 1 pulse per sec (1PPS) signal whose leading edge is synchronized with GPS seconds rollovers to well within the required accuracy. For each beam spill trigger at KEK, and each event trigger at Super-Kamiokande, 50 MHz free-running Local Time Clock (LTC) modules at each site provide fractional-second data with 20 nsec ticks. At each site, two GPS clocks run in parallel, providing hardware backup as well as data quality checks.
An Improved Harmony Search Algorithm for Constrained Multi-Objective Optimization (2013)

An improved harmony search algorithm for constrained multi-objective optimization problems is proposed in this paper. Inspired by Particle Swarm Optimization, an inductor particle is introduced to speed up the convergence rate of the CMOHS. Two populations are adopted to increase the opportunity of finding the optimal solutions. Numerical experiments are divided into two parts: the first one compares the CMOHS with NSGA-II, and the other one compares the CMOHS with the algorithm without the inductor individual. The results show that the CMOHS is more effective than NSGA-II, and the induction mechanism improved the convergence and diversity of the algorithm.
Amino acid sequence of a prothoracicotropic hormone of the silkworm <i>Bombyx mori</i> (1986)

We have determined the complete amino acid sequence of 4K-PTTH-II, one of three forms of the M(r) 4400 prothoracicotropic hormone of the silkworm Bombyx mori, active to brainless pupae of Samia cynthia ricini. Like vertebrate insulin, it consists of two nonidentical peptide chains (A and B chains). The A chain consists of 20 amino acid residues. The B chain is a mixture of four microheterogeneous peptides, two of which consist of 28 residues, and the other two, of 26 residues. 4K-PTTH-II has considerable sequence homology (40%) with human insulin, and it resembles porcine relaxin both in the carboxyl-terminal cysteine residue of the A chain and in the amino-terminal pyroglutamic acid residue of the B chain. The identical distribution of the six cysteine residues also indicates that 4K-PTTH-II belongs to the insulin family.
Imaging of extreme ultraviolet lithographic masks with programmed substrate defects (1994)

Extreme ultraviolet lithographic masks with programmed defects on the mask substrates have been imaged to study substrate defects printability. The imaging was performed with a 2-aspherical-mirror system operating at 14 nm wavelength. Results showed that 25 nm thick substrate defects caused observable distortions of resist patterns. Defects of sizes approximately half the minimum resolvable features resulted in 15%–20% variations in resist linewidths. However, since the imaging system was operating at a reduced resolution due to misalignments of the optics, the effect of the defects may have been partially concealed by the phase front distortions caused by mirror misalignments. The defects are difficult to observe under a scanning electron microscope.
Power consumption of multiplexed liquid-crystal displays (1982)

Display power consumption is calculated as a function of the physical display parameters for a five-voltage, line-at-a-time drive scheme. It is found that at high multiplexing levels the power varies as the product of the number of columns and the square of the number of rows, assuming that the rows are strobed. Typical power for a small 128 character display multiplexed at 1/28 duty cycle is expected to be 140 µW.
Trace analysis and mining for smart cities: issues, methods, and applications (2013)

Traces of moving objects in a city, which depict lots of semantics concerning human mobility and city dynamics, are becoming increasingly important. In this article, we first give a brief introduction to trace data; then we present six research issues in trace analysis and mining, and survey the state-of-the-art methods; finally, five promising application domains in smart cities are discussed.
Implementação de um sistema em linha para medida de concentrações de biomassa e metabolitos primários (2002)

Dado os inúmeros processos industriais que tem por base istemas fermentativos, é fundamental monitorizar as concentrações de biomassa e/ou dos respectivos produtos de fermentação. Esta monitorização é tanto mais eficaz quanto mais rápida e precisa for, pelo que é necessário estudar métodos para a sua implementação em linha de introdução. Neste artigo, pretende-se relacionar a quantidade consumida de reagente regulador do pH com a quantidade de uma enzima extracelular produzida, de modo a permitir o controlo dessa produção em linha. O sistema utilizado como modelo foi a fermentação de uma estirpe floculante da levedura Kluyveromyces marxíanus, utilizando glucose como fonte de carbono e energia. Esta estirpe produz uma enzima associada ao crescimento, a endopoligalacturonase. For
Flight of the Earls (1913)

I. A n-ainm Dhe.Ag so pairt; 4? sceloib 7 d' imthechtoib Ui Neill on uair f orfhagoip se Eire
Online Academic Support Peer Groups for Medical Undergraduates. (2012)

As advances in information and communication technologies give way to more innovative opportunities for teaching and learning at a distance, the need to provide supporting structures for online students similar to those offered to on-campus students is becoming more significant. Although a range of support services has been proposed in the past, there is a need for a comprehensive system which education specialists can use to provide online academic support for medical students working in peer groups. The goal of the investigation was to provide such a system, which has the potential to foster knowledge construction, through high levels of sociocognitive processing, ultimately resulting in enhanced academic achievement. The multi-dimensional approach to investigating this problem necessitated utilizing a combination of qualitative and quantitative methods. The design and development of the system were guided by results of a review of the relevant literature which revealed the necessary considerations for supporting students online. Implementation followed instructional design principles geared at success for online environments. To assess the impact of the use of the system, the following analyses were carried out: to assess the level of sociocognitive processing that took place, discourse analysis and group interaction analysis were carried out; to assess impact on academic achievement, a quasi-experimental approach was carried out, controlling for select variables between the two groups which were used; and to garner the lessons which were learned, observation and survey methodology were employed. The results revealed that students did not interact at high levels of sociocognitive processing and that there was no significant difference in the academic achievement between the treatment and control groups. Survey results provided reasons for lack of participation/interaction and recommendations were proposed for alternative implementations to encourage participation in this particular group which is medical students. The recent developments in social and mobile technologies have provided education specialists with a rich evolving field in which to harvest innovative methods of supporting students in online learning environments. It would be interesting to investigate how these new technologies can encourage active participation in support groups and the impact this support structure would have on academic achievement.
Effect of Shredding Alfalfa on Cellulolytic Activity, Digestibility, Rate of Passage, and Milk Production (1988)

A series of trials was performed with sheep and goats to compare mechanically shredded with conventionally (control) harvested alfalfa hay. Shredded hay tended to contain less CP and more cell wall constituents than the control; digestibility of NDF in vitro also was increased by shredding. Intake of DM and digestibilities of NDF and ADF were increased in sheep fed shredded hay. Digestibilities of DM and CP were similar between treatments. Total tract digestibilities determined using acid detergent lignin and Yb as internal and external markers were similar to those obtained by total collection. There was no effect of shredding on rate of passage and total mean retention time of hay in the digestive tract of sheep. Ruminal pH and VFA were not altered by shredding of hay. However, production of 4% FCM and milk protein content was increased in goats fed shredded hay. Shredded hay suspended in the rumen in situ had higher particle-associated carboxymethylcellulase activity throughout the incubation period than did control hay. The enzyme activity was maximal at 6 h and declined thereafter for both hays. The pattern of particle-associated carboxymethylcellulase activity was similar to that of NDF digestion in vitro.