gebhart/patrepeval huggingface dataset:
Software development issues for parallel processing (2003)

Parallel architectures for computers give rise to several issues with respect to software development. The issue to be resolved depends on the life-cycle phase in which the problem appears. During problem analysis and program design, the issue is best resolved by using an intelligent language environment, exemplified by the Rational R1000 Ada machine. During the post-implementation phase, an existing program can be restructured by using an expert tool that generates directed graph models of the program, analyzes the models and the source to identify potentially parallelizable code sequences, and through workstation window-oriented displays guides the user through the process of restructuring a program to run efficiently on a parallel architecture machine. An eight-step methodology for reworking existing Fortran programs for more efficient execution on parallel architecture machines is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
High throughput slotted ALOHA packet radio networks with adaptive arrays (1993)

The authors consider the use of a multiple-beam adaptive array (MBAA) in a packet radio system. In an MBAA, a given set of antenna elements is used to form several antenna patterns simultaneously. When it is used in a packet radio system, an MBAA can successfully receive two or more overlapping packets at the same time. Each beam captures a different packet by automatically pointing its pattern toward one packet while nulling other, contending packets. It is shown how an MBAA can be integrated into a single-hop slotted ALOHA packet radio system, and the resulting throughput is analyzed for both finite- and infinite-user populations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
EGFR-dependent migration of glial cells is mediated by reorganisation of N-cadherin (2008)

Receptor tyrosine kinases of the EGFR family exert their various effects on cellular function through the formation of different dimeric receptor complexes. To investigate the functional impact of EGFR-HER2 heterodimers on migration of glial tumour cells, we stably transfected different HER2 constructs, including a constitutively active (HER2VE) and a dominant-negative (HER2VEKA) receptor, in the EGFR-overexpressing human glioma cell line LN18. Interference of EGFR activation through HER2VEKA inhibited cellular migration, whereas EGFR activation through HER2VE increased migration. These results were corroborated by inhibition of EGFR-HER2 signalling with tyrosine kinase inhibitors, because only the blocking of both receptors in HER2VE-cells with the bi-specific inhibitor AEE788 downregulated migration to levels comparable with those in HER2VEKA cells. The non-migratory phenotype was mediated through upregulation of N-cadherin and its recruitment to the cell membrane in HER2VEKA cells; downregulation of N-cadherin by RNAi restored migration in HER2VEKA cells and N-cadherin was also downregulated in migrating HER2VE-cells. Downregulation of N-cadherin levels in the plasma membrane was accompanied by a direct interaction of the EGFR-HER2 and N-cadherin-beta-catenin complexes, leading to tyrosine phosphorylation of beta-catenin. These results indicate that HER2 affects glial-cell migration by modulating EGFR-HER2 signal transduction, and that this effect is mediated by N-cadherin.
Role Classification of Hosts within Enterprise Networks Based on Connection Patterns (2026)

Role classification involves grouping hosts into related roles. It exposes the logical structure of a network, simplifies network management tasks such as policy checking and network segmentation, and can be used to improve the accuracy of network monitoring and analysis algorithms such as intrusion detection. This paper defines the role classification problem and introduces two practical algorithms that group hosts based on observed connection patterns while dealing with changes in these patterns over time. The algorithms have been implemented in a commercial network monitoring and analysis product for enterprise networks. Results from grouping two enterprise networks show that the number of groups identified by our algorithms can be two orders of magnitude smaller than the number of hosts and that the way our algorithms group hosts highly reflects the logical structure of the networks.
Efficient Resource Allocation for Multiclass Services in Multiuser OFDM Systems (2009)

Although each application has its own quality of service (QoS) requirements, the resource allocation for multiclass services has not been studied adequately in multiuser orthogonal frequency division multiplexing (OFDM) systems. In this paper, a total transmit power minimization problem for downlink transmission is examined while satisfying multiclass services consisting of different data rates and target bit-error rates (BER). Lagrangian relaxation is used to find an optimal subcarrier allocation criterion in the context of subcarrier time-sharing by all users. We suggest an iterative algorithm using this criterion to find the upper and lower bounds of optimal power consumption. We also propose a prioritized subcarrier allocation (PSA) algorithm that provides low computation cost and performance very close to that of the iterative algorithm. The PSA algorithm employs subcarrier selection order (SSO) in order to decide which user takes its best subcarrier first over other users. The SSO is determined by the data rates, channel gain, and target BER of each user. The proposed algorithms are simulated in various QoS parameters and the fading channel model. Furthermore, resource allocation is performed not only subcarrier by subcarrier but also frequency block by frequency block (comprises several subcarriers). These extensive simulation environments provide a more complete assessment of the proposed algorithms. Simulation results show that the proposed algorithms significantly outperform existing algorithms in terms of total transmit power consumption.
Full-Scale System for Quantifying Loads and Leak Rates of Seals for Space Applications (2010)

NASA is developing advanced space-rated vacuum seals in support of future space exploration missions to low-Earth orbit and other destinations. These seals may be 50 to 60 in. (127 to 152 cm) in diameter and must exhibit extremely low leak rates to ensure that astronauts have sufficient breathable air for extended missions to the International Space Station or the Moon. Seal compression loads must be below prescribed limits so as not to overload the mechanisms that compress them during docking or mating, and seal adhesion forces must be low to allow two mated systems to separate when required. NASA Glenn Research Center has developed a new test apparatus to measure leak rates and compression and adhesion loads of candidate full-scale seals under simulated thermal, vacuum, and engagement conditions. Tests can be performed in seal-on-seal or seal-on-flange configurations at temperatures from -76 to 140 F (-60 to 60 C) under operational pressure gradients. Nominal and off-nominal mating conditions (e.g., incomplete seal compression) can also be simulated. This paper describes the main design features of the test apparatus as well as techniques used to overcome some of the design challenges.
Room-Temperature Triggered Single Photon Emission from a III-Nitride Site-Controlled Nanowire Quantum Dot (2014)

We demonstrate triggered single photon emission at room temperature from a site-controlled III-nitride quantum dot embedded in a nanowire. Moreover, we reveal a remarkable temperature insensitivity of the single photon statistics, and a g((2))[0] value at 300 K of just 0.13. The combination of using high-quality, small, site-controlled quantum dots with a wide-bandgap material system is crucial for providing both sufficient exciton confinement and an emission spectrum with minimal contamination in order to enable room temperature operation. Arrays of such single photon emitters will be useful for room-temperature quantum information processing applications such as on-chip quantum communication.
Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA (2016)

CagA, encoded by cytotoxin-associated gene A (cagA), is a major virulence factor of Helicobacter pylori, a gastric pathogen involved in the development of upper gastrointestinal diseases. Infection with cagA-positive H. pylori may also be associated with diseases outside the stomach, although the mechanisms through which H. pylori infection promotes extragastric diseases remain unknown. Here, we report that CagA is present in serum-derived extracellular vesicles, known as exosomes, in patients infected with cagA-positive H. pylori (n = 4). We also found that gastric epithelial cells inducibly expressing CagA secrete exosomes containing CagA. Addition of purified CagA-containing exosomes to gastric epithelial cells induced an elongated cell shape, indicating that the exosomes deliver functional CagA into cells. These findings indicated that exosomes secreted from CagA-expressing gastric epithelial cells may enter into circulation, delivering CagA to distant organs and tissues. Thus, CagA-containing exosomes may be involved in the development of extragastric disorders associated with cagA-positive H. pylori infection.
Modification of bovine pancreatic ribonuclease A with the site-specific reagent 4-arsono-2-nitrofluorobenzene. Spectrophotometric titration of arsononitrophenyl ribonuclease A derivatives (1981)

The 4-arsono-2-nitrophenyl chromophore can serve as a versatile spectrophotometric probe of the surface structure of proteins. Values of pK1' and pK2' for the arsonic acid ionizations are near 3 and 8, respectively, and the presence of nearby positive and negative charges produces substantial alterations in the spectral response of the probe. Changes in the extinction at the wavelength of maximum difference are 30-50% of the extinction coefficients, epsilonmax, for each ionization of the arsonic acid moiety. The titration of 41-(4-arsono-2-nitrophenyl)ribonuclease A indicates that the arsonate dianion binds near the active-site histidine residues. With protonation of a carboxylate side chain in the acidic region, presumably aspartic acid-121, the active site is disrupted. The 41-(4-arsono-2-nitrophenyl) group interacts to a greater degree with the histidine-119 side chain than it does with the histidine-12 residue. Interactions of uridine or 3'-cytidylic acid with the ligand-binding region of 41-(4-arsono-2-nitrophenyl) ribonuclease A modify the spectrophotometric response extensively. 3'-Cytidylic acid binds 41-(4-arsono-2-nitrophenyl) ribonuclease A with an affinity 300 times less than that for native ribonuclease A and 17 times lower than that for 41-(2,4-dinitrophenyl) ribonuclease A. The arsononitrophenyl chromophore is responsive to changes in the active site of ribonuclease A induced by such perturbants as ligand binding, chemical modification, and both acid and thermal denaturation.
Somatotopic Activation in the Human Trigeminal Pain Pathway (2002)

Functional magnetic resonance imaging was used to image pain-associated activity in three levels of the neuraxis: the medullary dorsal horn, thalamus, and primary somatosensory cortex. In nine subjects, noxious thermal stimuli (46 degrees C) were applied to the facial skin at sites within the three divisions of the trigeminal nerve (V1, V2, and V3) and also to the ipsilateral thumb. Anatomical and functional data were acquired to capture activation across the spinothalamocortical pathway in each individual. Significant activation was observed in the ipsilateral spinal trigeminal nucleus within the medulla and lower pons in response to at least one of the three facial stimuli in all applicable data sets. Activation from the three facial stimulation sites exhibited a somatotopic organization along the longitudinal (rostrocaudal) axis of the brain stem that was consistent with the classically described "onion skin" pattern of sensory deficits observed in patients after trigeminal tractotomy. In the thalamus, activation was observed in the contralateral side involving the ventroposteromedial and dorsomedial nuclei after stimulation of the face and in the ventroposterolateral and dorsomedial nuclei after stimulation of the thumb. Activation in the primary somatosensory cortex displayed a laminar sequence that resembled the trigeminal nucleus, with V2 more rostral, V1 caudal, and V3 medial, abutting the region of cortical activation observed for the thumb. These results represent the first simultaneous imaging of pain-associated activation at three levels of the neuraxis in individual subjects. This approach will be useful for exploring central correlates of plasticity in models of experimental and clinical pain.
The use of high aspect ratio photoresist (SU-8) for super-hydrophobic pattern prototyping (2004)

In this work we present a reliable technique for the production of large areas of high aspect ratio patterns and their use as model super-hydrophobic systems. The high thickness and straight sidewalls possible with SU-8 were used to generate dense patterns of small pillars. The photoresist patterns could be used directly, without the need for micromoulding. A method is given allowing resist thickness to be varied over a wide range and a bottom antireflective layer was used to ease patterning on reflective substrates. This patterning technique allows rapid testing of wetting theories, as pattern size and depth can be varied simply and samples can be produced in sufficient numbers for laboratory use. We show how the static contact angle of water varies with pattern height for one sample-pattern and how static and dynamic contact angles vary with dimension using high aspect-ratio patterns.
The effect of lubrication on friction, wear and abrasion (1951)

The lubrication of a grinding surface is one of the most important items in abrasive processes, and experimental work on it is reported. Recent tests, in which the coefficient of friction was measured by an electronic dynamometer, employed a cast-iron disk in contact with a lubricated diamond surface. Using various oils, the coefficient of friction was generally below 0.08 without diamond powder and about 0.11 with the powder.
Green branding effects on attitude: functional versus emotional positioning strategies (2005)

Abstract Purpose – Proposes a set of strategic options for green brand positioning, based either on functional brand attributes or on emotional benefits. The aim of the study is to test the suggested green positioning strategies against one another, assessing their effect on perceived brand positioning and brand attitude. Design/methodology/approach – A theoretical model of the dimensionality and attitudinal effects of green brand positioning was developed. Both suggested alternatives to green brand positioning, along with a combined functional and emotional strategy, were tested in an experimental online setting. The hypothesized model was tested in the scope of exploratory factor analysis and structural equation modelling. Findings – Results indicate an overall positive influence of green brand positioning on brand attitude. Further findings suggest distinct functional and emotional dimensions of green brand positioning with the interaction of both dimensions in the formation of brand attitude. Highest perceptual effects were achieved through a green positioning strategy that combined functional attributes with emotional benefits. Research limitations/implications – The measures used, while providing good reliability and validity, have their limitations, especially in the case of the emotional dimension of green brand associations. Future research should concentrate on the further development of the constructs used in the study, particularly that of the emotional dimension of green brand associations and replicate the study under "real‐life" conditions within different product categories and with a representative sample. Practical implications – A well implemented green positioning strategy can lead to a more favourable perception of the brand, giving support to the green marketing approach in general. This study supports significant attitude effects of both functional and emotional green positioning strategies. Thus, brand managers should deliver emotional benefits through the brand, at the same time making sure that target groups perceive real environmental benefits. Originality/value – Although green marketing has been an important research topic for more than three decades, hardly any research has been conducted that focuses specifically on green branding. This paper analyses the dimensionality of green brand positioning, offers green branding insight and suggests strategic tools for brand managers.
Etched Colloidal LiFePO<sub>4</sub>Nanoplatelets toward High-Rate Capable Li-Ion Battery Electrodes (2014)

LiFePO4 has been intensively investigated as a cathode material in Li-ion batteries, as it can in principle enable the development of high power electrodes. LiFePO4, on the other hand, is inherently "plagued" by poor electronic and ionic conductivity. While the problems with low electron conductivity are partially solved by carbon coating and further by doping or by downsizing the active particles to nanoscale dimensions, poor ionic conductivity is still an issue. To develop colloidally synthesized LiFePO4 nanocrystals (NCs) optimized for high rate applications, we propose here a surface treatment of the NCs. The particles as delivered from the synthesis have a surface passivated with long chain organic surfactants, and therefore can be dispersed only in aprotic solvents such as chloroform or toluene. Glucose that is commonly used as carbon source for carbon-coating procedure is not soluble in these solvents, but it can be dissolved in water. In order to make the NCs hydrophilic, we treated them with lithium hexafluorophosphate (LiPF6), which removes the surfactant ligand shell while preserving the structural and morphological properties of the NCs. Only a roughening of the edges of NCs was observed due to a partial etching of their surface. Electrodes prepared from these platelet NCs (after carbon coating) delivered a capacity of ∼ 155 mAh/g, ∼ 135 mAh/g, and ∼ 125 mAh/g, at 1 C, 5 C, and 10 C, respectively, with significant capacity retention and remarkable rate capability. For example, at 61 C (10.3 A/g), a capacity of ∼ 70 mAh/g was obtained, and at 122 C (20.7 A/g), the capacity was ∼ 30 mAh/g. The rate capability and the ease of scalability in the preparation of these surface-treated nanoplatelets make them highly suitable as electrodes in Li-ion batteries.
BARRIER LOWERING AND FIELD PENETRATION AT METAL-DIELECTRIC INTERFACES (1966)

We report here photoemission measurements on\nSi-SiO_2-Al structures in which the metal-SiO_2\nbarrier energy has been determined as a function\nof the electric field strength E in the dielectric. The\nexpected barrier lowering is the sum of two terms:\na) the Schottky term, proportional to E^(1/2) and b)\na term due to the penetration of the electric field\ninto the metal electrode, proportional to E. The\nexperimental results are in good agreement with\nthe model, where the Schottky effect involves the\noptical value of the dielectric constant of the oxide\nand the Thomas-Fermi screening distance in the\nmetal is 1 Å. To our knowledge this represents the\nfirst unambiguous quantitative determination of either effect in a polar dielectric, although the\nSchottky effect alone has been observed in silicon.
Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket (2016)

Janus kinases (JAKs) are a family of cytoplasmatic tyrosine kinases that are attractive targets for the development of anti-inflammatory drugs given their roles in cytokine signaling. One question regarding JAKs and their inhibitors that remains under intensive debate is whether JAK inhibitors should be isoform selective. Since JAK3 functions are restricted to immune cells, an isoform-selective inhibitor for JAK3 could be especially valuable to achieve clinically more useful and precise effects. However, the high degree of structural conservation makes isoform-selective targeting a challenging task. Here, we present picomolar inhibitors with unprecedented kinome-wide selectivity for JAK3. Selectivity was achieved by concurrent covalent reversible targeting of a JAK3-specific cysteine residue and a ligand-induced binding pocket. We confirmed that in vitro activity and selectivity translate well into the cellular environment and suggest that our inhibitors are powerful tools to elucidate JAK3-specific functions.
A Combination Of Amoxicillian And Clavulanic Acid In The Treatment Of Impetigo In Children (1998)

Amoxicillin plus clavulanic acid (ACA) a combination of potentially effective antibiotic against beta-lactamase producing bacteria was compared with that of amoxicillin, erythomycin and co-trimoxazole in an open label, randomized trial in 100 children with mild to severe impetigo. 22% children had mild, 25% had moderate and 53% children had severe impetigo. Pure growth of S. aureus was isolated in 68% children, S.pyogenes in 26% and both staphyto and streptococci in 6% children. In mild to moderate infection 100% children receiving ACA were cured clinically after first week, whereas 7 out of 15(46.6%) children in amoxicillin group, 7 out of 13(53.1%) children in erythromycin group and 4 out 12 (33.3%) children in co-trimoxazole group showed clinical cure after first week. In severe impetigo 46.1% children receiving ACA, 20% children in amoxicillin group, 16.6% children inerythromycin group and 7.6% in co-trimoxazole group showed clinical cure on therapy after one week. ACA was well tolerated in children.
Stereoselective Preparation of Protected Thymine Polyoxin C and Approaches Towards Synthesis of Its C2′-Modified Analogues (2001)

Polyoxins form an important class of pyrimidine peptide antifungal agents. The preparation of thymine polyoxin C, which is the nucleosidic component of some polyoxins, is reported, together with attempts to synthesize C2′-fluoro analogues. Epimeric 3-hydroxyazidolactones 2a and 2b, obtained from diastereoisomeric epoxy hydroxy esters, were dehydrated to afford butenolide 3. Dihydroxylation and further functional manipulation yielded thymine polyoxin C. Attempts to form the 2,2′-anhydronucleoside and to direct nucleophilic fluorination with DAST on a monoprotected nucleoside were unsuccessful. Electrophilic fluorination of azidolactone with NFSI permitted the formation of an α-fluorolactone, which is an interesting intermediate for the preparation of a C2′-fluoro analogue.
Élaboration d'un balanced scorecard en milieu hospitalier (2011)

Cet article, fonde sur une recherche-intervention realisee aupres d’equipes mobiles de geriatrie, propose une methodologie constructiviste d’elaboration d’un balanced scorecard pour le controle strategique de ces organisations. Le contexte hospitalier et le caractere atypique de ces equipes, en quete de legitimite au sein des hopitaux, justifient cette approche non normative de deploiement d’un outil strategique de controle.
Two‐Component Polymer Scaffolds for Controlled Three‐Dimensional Cell Culture (2011)

Two-component 3D polymer scaffolds with distinct mechanical and protein-binding properties are fabricated using direct laser writing. With this method, full control over the formation of cell adhesion sites and, consequently, cell shape in three dimensions can be achieved. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.