gebhart/patrepeval huggingface dataset:
Transferring functional grasps through contact warping and local replanning (2012)

We present a method for transferring grasps between objects of the same functional category. This transfer is intended to preserve the functionality of a grasp constructed for one of the objects, thus enabling the analogous action to be performed on a novel object for which no grasp has been specified. Manipulation knowledge is hence generalized from a single example to a class of objects with a significant amount of shape variability. The transfer is achieved through warping the surface geometry of the source object onto the target object, and along with it the contact points of a grasp. The warped contacts are locally replanned, if necessary, to ensure grasp stability, and a suitable grasp pose is computed. We present extensive results of experiments with a database of four-finger grasps, designed to systematically cover variations on grasping the mugs of the Princeton Shape Benchmark.
Low Pt Alloyed Nanostructures for Fuel Cells Catalysts (2018)

Low-noble metal electrocatalysts are attracting massive attention for anode and cathode reactions in fuel cells. Pt transition metal alloy nanostructures have demonstrated their advantages in high performance low-noble metal electrocatalysts due to synergy effects. The basic of designing this type of catalysts lies in understanding structure-performance correlation at the atom and electron level. Herein, design threads of highly active and durable Pt transition metal alloy nanocatalysts are summarized, with highlighting their synthetic realization. Microscopic and electron structure characterization methods and their prospects will be introduced. Recent progress will be discussed in high active and durable Pt transition metal alloy nanocatalysts towards oxygen reduction and methanol oxidation, with their structure-performance correlations illustrated. Lastly, an outlook will be given on promises and challenges in future developing of Pt transition metal alloy nanostructures towards fuel cells catalysis uses.
Tomato Lycopene and Inflammatory Cascade: Basic Interactions and Clinical Implications (2010)

Lycopene, a natural carotenoid found in tomato, has been reported to possess various health benefits, such as cardiovascular and cancer preventive properties. However, the experimental basis for such health benefits is not fully understood. One of the possible mechanisms for its protective activities is by down-regulation of the inflammatory response. That includes the inhibition of pivotal pro-inflammatory mediators, such as the reduction of reactive oxygen species, the inhibition of synthesis and release of pro-inflammatory cytokines, changes in the expression of cyclooxygenase and lipoxygenase, modifications of eicosanoid synthesis, and modulation of signal transduction pathways, including that of the inducible nitric oxide synthase via its inhibitory effects on Nuclear Factor-kB (NF-kB), Activated protein-1 (AP-1) and mitogen-activated protein kinase (MAPK) signaling. Recent data suggest that lycopene also exhibits anti-inflammatory activity through induction of programmed cell death in activated immune cells. This review will discuss recent data on the control of inflammatory signaling exerted by tomato lycopene in isolated cells, in animal models and in clinical trials, focusing on the dose of the carotenoid and the biological environment in which it acts. A clear understanding of the molecular mechanisms of action of lycopene is crucial in the valuation of this molecule as a potential preventive and therapeutic agent.
Detecting eye contact using wearable eye-tracking glasses (2012)

We describe a system for detecting moments of eye contact between an adult and a child, based on a single pair of gaze-tracking glasses which are worn by the adult. Our method utilizes commercial gaze tracking technology to determine the adult's point of gaze, and combines this with computer vision analysis of video of the child's face to determine their gaze direction. Eye contact is then detected as the event of simultaneous, mutual looking at faces by the dyad. We report encouraging findings from an initial implementation and evaluation of this approach.
Hormonal indicators of pregnancy in llamas and alpacas (1996)

The first increase in estrone sulfate concentration over basal values may indicate early interaction between mother and embryo, whereas the second increase may reflect fetal viability. Use of estrone sulfate concentration to diagnose pregnancy in llamas and alpacas is highly dependent on time of sampling. Relaxin concentration in serum is a superior indicator of pregnancy after the second month in the Ilama and alpaca because its existence is suggestive of interaction between mother and fetus, and concentrations are greater than basal values for a long period of pregnancy. Progesterone is not a direct product of the embryo or fetus and only indirectly confirms a diagnosis of pregnancy.
Left ventricular dysfunction, natriuretic peptides, and mortality in an urban population (2001)

OBJECTIVE To report the mortality of left ventricular systolic dysfunction (LVD), assessed objectively by echocardiography, and its association with natriuretic peptide hormones in a random sample of 1640 men and women aged 25–74 years from a geographical, urban population. METHODS Left ventricular function was measured by echocardiography in 1640 attendees studied in 1992–3. LVD was defined as a left ventricular ejection fraction (LVEF) ⩽ 30%. Plasma concentrations of N-terminal atrial natriuretic peptide (N-ANP) and brain natriuretic peptide (BNP) were measured by standard radioimmunoassays. Mortality was documented at four years. RESULTS The four year all cause mortality rate in the whole cohort was 4.9% (80 deaths). It was 21% (nine deaths) in those with an LVEF ⩽ 30% and 4% in those whose LVEF was > 30% (p < 0.001). The median (interquartile range) BNP concentration in those who died was 16.9 pg/ml (8.8–27) and 7.8 pg/ml (3.4–13) in survivors (p < 0.0001). Similarly, N-ANP had a median concentration of 2.35 ng/ml (1.32–3.36) in those with a fatal outcome and 1.27 ng/ml (0.9–2.0) in those alive at four years (p < 0.0001). Subjects with an LVEF ⩽ 40% also had a significant mortality rate of 17% if they also had a BNP concentration ⩾ 17.9 pg/ml compared with 6.8% if their BNP was below this concentration (p = 0.013). Multivariate analysis revealed the independent predictors of four year all cause mortality to be increasing age (p < 0.001), a BNP concentration ⩾ 17.9 pg/ml (p = 0.006), the presence of ischaemic heart disease (p = 0.03), and male sex (p = 0.04). CONCLUSIONS LVD is associated with a considerable mortality rate in this population. BNP also independently predicts outcome. In addition to its role as a diagnostic aid in chronic heart failure and LVD, it provides prognostic information and clarifies the meaning of a given degree of LVD.
Antiulcerogenic Activities of the Extracts and Isolated Flavonoids of <i>Euphorbia cuneata</i> Vahl (2012)

The total alcohol extracts of Euphorbia cuneata Vahl.(Euphorbiaceae) were screened for antiulcerogenic activity using an ethanol-induced ulcer model at doses of 125, 250 and 500 mg/kg. The extracts possessed antiulcerogenic activity in a dose-dependent manner. Four flavonoidal compounds were isolated and identified as naringenin, aromadendrin, apigenin and 4'-O-methoxy-luteolin-7-O-rhamnoglucoside, each demonstrating antiulcerogenic activity with curative ratios ranging from 75.78% to 88.23%. In addition, the alcohol extracts and isolated compounds were shown to scavenge the 1,1-diphenyl,2-picrylhydrazyl radical by different ratio, with the most effective being 4'-O-methoxy-luteolin-7-O-rhamnoglucoside (91.14%). The antioxidant activity of the alcohol extracts and the isolated compounds may explain the antiulcerogenic properties. No side effects were observed on either liver or kidney functions.
Basic Research Needs for Electrical Energy Storage. Report of the Basic Energy Sciences Workshop on Electrical Energy Storage, April 2-4, 2007 (2007)

To identify research areas in geosciences, such as behavior of multiphase fluid-solid systems on a variety of scales, chemical migration processes in geologic media, characterization of geologic systems, and modeling and simulation of geologic systems, needed for improved energy systems.
Interchain and intrachain disulphide bonds in human platelet glycoprotein IIb. Localization of the epitopes for several monoclonal antibodies (1989)

The single interchain disulphide bond in platelet glycoprotein IIb (GPIIb) is accessible to extracellular reductants, and selective cleavage does not liberate GPIIb alpha from platelet plasma membrane, confirming that non-covalent interactions contribute to maintaining attachment of this subunit to the membrane. Eosin-maleimide labelling of isolated GPIIb after selective cleavage of this interchain disulphide bond, followed by full reduction and alkylation, CNBr cleavage, and analysis of the cleavage products allowed us to establish that this interchain disulphide bridge is formed between GPIIb beta (GPIIb beta-subunit) Cys-9 and GPIIb alpha Cys-826, and this conclusion was confirmed by independent routes. The other two cysteines of GPIIb beta (Cys-14 and Cys-19) form the single intrachain disulphide bond in this subunit. Last, the intrachain disulphides in GPIIb alpha (GPIIb alpha-subunit) are distributed in four main peptide domains which are not disulphide-bonded among themselves. The linear epitope for monoclonal antibody M1 is localized between Pro-4 and Met-24 (or Met-31) of GPIIb beta. The linear epitope for M3 is situated between Cys-826 and the C-terminus of GPIIb alpha. The M4 epitope is also linear and localized somewhere between residues 115 and 285 of GPIIb alpha. Finally, the epitopes for M5 and M6 are somewhere between Cys-608 and Met-704, within a 35 kDa membrane-bound chymotryptic product of digestion of GPIIb in whole platelets. The N-terminal amino acid sequences determined for eight different cleavage products of GPIIb alpha and GPIIb beta agree with the corresponding amino acid sequences predicted by cDNA sequence for human-erythroleukaemic-cell GPIIb [Poncz, Eisman, Heindenreich, Silver, Vilaire, Surrey, Schwartz & Bennett (1987) J. Biol. Chem. 262, 8476-8482].
Increasing the Dissolution Rate of some Benzothiadiazine Derivatives by Solid and Liquid Dispersion Techniques (1982)

Dissolution rates of water-insoluble drugs such as Chlorothiazide, Hydrochlorothiazide, Flumethiazide and Cyclopenthiazide were markedly increased when dispersed in polyethylene glycol 6000. The increased dissolution rate was believed to be attributed to the molecular and for the colloidal dispersion of the drug in the matrix of PEG 6000. Bendroflumethiazide and Methylclothiazide were found to be decomposed by either of dispersion techniques.
ANALYSIS OF TWO-FLUID MODEL USING GPS DATA (2005)

It is difficult to macroscopically characterize urban transportation network with various traffic operation components. Two-fluid model that was suggested by Herman and Prigogine (1979) is well known as a predominant method based on traffic flow theory, which provides a macroscopic measure of the quality of traffic service in an urban transportation network. The two-fluid model needs individual probe vehicle data such as total travel time, stop and running time per unit distance. Therefore, it is very difficult to collect these input data for practical applications. This paper presents the application of GPS data to the two-fluid model for the Kangnam supernetwork in Seoul. The result shows that the GPS data is reliable to estimate the two-fluid model parameters. There are many applications of two-fluid model to urban transportation network in the world, and if more researches are conducted, it is obvious that the two-fluid model would be a useful method to analyze urban transportation network theoretically.
Volume control of erythrocytes during storage (1988)

When red cells are stored as suspensions in artificial preservative solutions such as those consisting of saline, adenine, and glucose, increased hemolysis of the red cells occurs in vitro, a phenomenon that is readily prevented by the addition of mannitol. The mechanism by which mannitol prevents hemolysis is unknown. The authors have examined the possibility that mannitol prevents hemolysis by prevention of osmotic swelling of red cells that might otherwise increase their volume beyond their critical hemolytic volume. Storage in artificial media does, indeed, result in swelling of the red cells, which is prevented by mannitol and is increased by the addition of nystatin, an agent that greatly increases the sodium-potassium permeability of the cells. Swelling and hemolysis are correlated at different concentrations of mannitol, but the correlation breaks down when the case of nystatin-treated cells is considered; even with marked swelling, there is relatively little hemolysis. Moreover, increasing the volume of the stored red cells acutely by osmotic means results in relatively little additional hemolysis. These findings make it appear unlikely that simple osmotic lysis is the cause of hemolysis in stored cells. Some other stabilizing effect of mannitol that may or may not be related to its osmotic effect must play a role.
Enones with strained double bonds. 4. Bicyclo[5.3.1]undecane system (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnones with strained double bonds. 4. Bicyclo[5.3.1]undecane systemHerbert O. House, Ronald F. Sieloff, Thomas V. Lee, and Marvin B. DeTarCite this: J. Org. Chem. 1980, 45, 10, 1800–1806Publication Date (Print):May 1, 1980Publication History Published online1 May 2002Published inissue 1 May 1980https://pubs.acs.org/doi/10.1021/jo01298a012https://doi.org/10.1021/jo01298a012research-articleACS PublicationsRequest reuse permissionsArticle Views569Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Topical application of analgesics: a clinical option in day case anaesthesia? (2010)

A variety of targets for peripherally applied analgesics exists, some of which can be accessed using currently available drugs, whereas others may need development of new formulations before they can be clinically targeted.
A System for Robotic Heart Surgery that Learns to Tie Knots Using Recurrent Neural Networks (2006)

Tying suture knots is a time-consuming task performed frequently during minimally invasive surgery (MIS). Automating this task could greatly reduce total surgery time for patients. Current solutions to this problem replay manually programmed trajectories, but a more general and robust approach is to use supervised machine learning to smooth surgeon-given training trajectories and generalize from them. Since knottying generally requires a controller with internal memory to distinguish between identical inputs that require different actions at different points along a trajectory, it would be impossible to teach the system using traditional feedforward neural nets or support vector machines. Instead we exploit more powerful, recurrent neural networks (RNNs) with adaptive internal states. Results obtained using LSTM RNNs trained by the recent Evolino algorithm show that this approach can significantly increase the efficiency of suture knot tying in MIS over preprogrammed control
Mouse inbred strain differences in ethanol drinking to intoxication (2006)

Recently, we described a simple procedure, Drinking in the Dark (DID), in which C57BL/6J mice self-administer ethanol to a blood ethanol concentration (BEC) above 1 mg/ml. The test consists of replacing the water with 20% ethanol in the home cage for 4 h early during the dark phase of the light/dark cycle. Three experiments were conducted to explore this high ethanol drinking model further. In experiment 1, a microanalysis of C57BL/6J behavior showed that the pattern of ethanol drinking was different from routine water intake. In experiment 2, drinking impaired performance of C57BL/6J on the accelerating rotarod and balance beam. In experiment 3, 12 inbred strains were screened to estimate genetic influences on DID and correlations with other traits. Large, reliable differences in intake and BEC were detected among the strains, with C57BL/6J showing the highest values. Strain means were positively correlated with intake and BEC in the standard (24 h) and a limited (4 h) two-bottle ethanol vs. water test, but BECs reached higher levels for DID. Strain mean correlations with other traits in the Mouse Phenome Project database supported previously reported genetic relationships of high ethanol drinking with low chronic ethanol withdrawal severity and low ethanol-conditioned taste aversion. We extend these findings by showing that the correlation estimates remain relatively unchanged even after correcting for phylogenetic relatedness among the strains, thus relaxing the assumption that the strain means are statistically independent. We discuss applications of the model for finding genes that predispose pharmacologically significant drinking in mice.
Google Maps Hacks: Tips & Tools for Geographic Searching and Remixing (Hacks) (2006)

Want to find every pizza place within a 15-mile radius? Where the dog parks are in a new town? The most central meeting place for your class, club or group of friends? The cheapest gas stations on a day-to-day basis? The location of convicted sex offenders in an area to which you may be considering moving? The applications, serendipitous and serious, seem to be infinite, as developers find ever more creative ways to add to and customize the satellite images and underlying API of Google Maps. Written by Schuyler Erle and Rich Gibson, authors of the popular Mapping Hacks, Google Maps Hacks shares dozens of tricks for combining the capabilities of Google Maps with your own datasets. Such diverse information as apartment listings, crime reporting or flight routes can be integrated with Google's satellite imagery in creative ways, to yield new and useful applications.The authors begin with a complete introduction to the standard features of Google Maps. The adventure continues with 60 useful and interesting mapping projects that demonstrate ways developers have added their own features to the maps. After that's given you ideas of your own, you learn to apply the techniques and tools to add your own data to customize and manipulate Google Maps. Even Google seems to be tacitly blessing what might be seen as unauthorized use, but maybe they just know a good thing when they see one.With the tricks and techniques you'll learn from Google Maps Hacks, you'll be able to adapt Google's satellite map feature to create interactive maps for personal and commercial applications for businesses ranging from real estate to package delivery to home services, transportation and more. Includes a foreword by Google Maps tech leads, Jens and Lars Rasmussen.
A 1-GS/s 6-Bit Two-Channel Two-Step ADC in 0.13-$\mu$m CMOS (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> In this paper, a 6-bit 1-GS/s 49 mW two-channel two-step analog-to-digital converter (ADC) without calibration is implemented in 0.13-<formula formulatype="inline"> <tex Notation="TeX">$\mu{\hbox {m}}$</tex></formula> CMOS process. The proposed multiplying digital-to-analog converter (MDAC) processes the analog signal with two clock periods for one conversion: half for sampling, half for Coarse ADC (CADC) resolving, and one for residue amplification. A self-timing technique is used to prevent disturbance at the beginning of the residue amplification. The reduction of the MDAC output swing by enhancing the accuracy of CADC increases the output devices' over-drive voltage and decreases output loading. The proposed design methods allow closed-loop MDAC to operate at high speed while maintaining low power consumption. The measured SFDR, SNR, and SNDR are 40.7 dB, 33.8 dB, and 33.7 dB, respectively, at the Nyquist rate input. The ADC power dissipation is 49 mW and corresponds to a figure-of-merit (FoM) of 1.24 pJ/conv.-step. The active area occupies 0.16<formula formulatype="inline"><tex Notation="TeX">$~{\hbox {mm}}^{2}$</tex></formula>. </para>
Scanning the human genome at kilobase resolution (2008)

Normal genome variation and pathogenic genome alteration frequently affect small regions in the genome. Identifying those genomic changes remains a technical challenge. We report here the development of the DGS (Ditag Genome Scanning) technique for high-resolution analysis of genome structure. The basic features of DGS include (1) use of high-frequent restriction enzymes to fractionate the genome into small fragments; (2) collection of two tags from two ends of a given DNA fragment to form a ditag to represent the fragment; (3) application of the 454 sequencing system to reach a comprehensive ditag sequence collection; (4) determination of the genome origin of ditags by mapping to reference ditags from known genome sequences; (5) use of ditag sequences directly as the sense and antisense PCR primers to amplify the original DNA fragment. To study the relationship between ditags and genome structure, we performed a computational study by using the human genome reference sequences as a model, and analyzed the ditags experimentally collected from the well-characterized normal human DNA GM15510 and the leukemic human DNA of Kasumi-1 cells. Our studies show that DGS provides a kilobase resolution for studying genome structure with high specificity and high genome coverage. DGS can be applied to validate genome assembly, to compare genome similarity and variation in normal populations, and to identify genomic abnormality including insertion, inversion, deletion, translocation, and amplification in pathological genomes such as cancer genomes.
Rationale for a Phase I Trial of Erlotinib and the Mammalian Target of Rapamycin Inhibitor Everolimus (RAD001) for Patients with Relapsed Non–Small Cell Lung Cancer (2007)

Everolimus has an appropriate rationale for therapeutic use in combination with erlotinib for patients with NSCLC. This manuscript will review the preclinical rationale for undertaking a study of erlotinib combined with everolimus for patients with relapsed NSCLC.