gebhart/patrepeval huggingface dataset:
Bone marrow transplantation for autoimmune diseases (1999)

Autoimmune diseases afflict approximately 2% of the US population and span virtually every medical specialty. Most patients with autoimmune diseases have a normal life expectancy and are managed conservatively; however, a subset of patients have a progressive disease course associated with significant morbidity and mortality. High-dose cytotoxic therapy followed by autologous stem cell transplantation has been proposed as a novel treatment for severe autoimmune diseases. This review will focus on recent advances in the immunopathogenesis of autoimmunity and will review preliminary results of clinical trials employing hematopoietic stem cell transplantation for the treatment of autoimmunity.
Comparative Metaproteomics and Diversity Analysis of Human Intestinal Microbiota Testifies for Its Temporal Stability and Expression of Core Functions (2012)

The human intestinal tract is colonized by microbial communities that show a subject-specific composition and a high-level temporal stability in healthy adults. To determine whether this is reflected at the functional level, we compared the faecal metaproteomes of healthy subjects over time using a novel high-throughput approach based on denaturing polyacrylamide gel electrophoresis and liquid chromatography-tandem mass spectrometry. The developed robust metaproteomics workflow and identification pipeline was used to study the composition and temporal stability of the intestinal metaproteome using faecal samples collected from 3 healthy subjects over a period of six to twelve months. The same samples were also subjected to DNA extraction and analysed for their microbial composition and diversity using the Human Intestinal Tract Chip, a validated phylogenetic microarray. Using metagenome and single genome sequence data out of the thousands of mass spectra generated per sample, approximately 1,000 peptides per sample were identified. Our results indicate that the faecal metaproteome is subject-specific and stable during a one-year period. A stable common core of approximately 1,000 proteins could be recognized in each of the subjects, indicating a common functional core that is mainly involved in carbohydrate transport and degradation. Additionally, a variety of surface proteins could be identified, including potential microbes-host interacting components such as flagellins and pili. Altogether, we observed a highly comparable subject-specific clustering of the metaproteomic and phylogenetic profiles, indicating that the distinct microbial activity is reflected by the individual composition.
Developing principles of GUI programming using views (2004)

This paper proposes that GUI development is as important as other aspects of programming, such as a sound understanding of control structures and object orientation. Far less attention has been paid to the programming structures for GUIs and certainly there are few cross language principles to aid the programmer. We propose that principles of GUIs can be extracted and learnt, and that they do enhance good programming practice. These principles have been implemented in our Views system which features an XML-based GUI description notation coupled with an engine that shields the programmer from much of the intricate complexity associated with events, listeners and handlers. The system is programmed primarily in C# for .NET, but is available in various forms for Java and for other platforms which support .NET through the SSCLI.
Characterization and Energy Storage Density of BaTiO<sub>3</sub> - Ba(Mg<sub>1/3</sub>Nb<sub>2/3</sub>)O<sub>3</sub> Ceramics (2010)

The energy storage density of (1-x) BaTiO3 – x Ba(Mg1/3Nb2/3)O3 (x = 0, 0.1, 0.2, 0.3) ceramics was investigated. The microstructure of samples was characterized by scanning electron microscopy (SEM). The energy storage density was calculated from the P-E hysteresis loops measured at room temperature. Experimental results show that the energy storage density of 0.9 BaTiO3 – 0.1 Ba(Mg1/3Nb2/3)O3 ceramics is highest among all compositions. At 15.8kV/mm electric field, the energy storage density of the sample can reach up to 1.07J/cm3, which is about 1.5 times higher than pure BaTiO3. The improvement of the energy density can be due to two factors: one is the improved breakdown strength caused by the optimized microstructure, the other is the decreased remnant polarization. This result indicates that bulk 0.9 BaTiO3 – 0.1 Ba(Mg1/3Nb2/3)O3 ceramic has advantages compared with pure BaTiO3 ceramic for energy storage applications, and with further improvements in microstructure and reduction of sintering temperature, could be a good candidate for energy storage capacitors.
H-Ras Modulates N-Methyl-D-aspartate Receptor Function via Inhibition of Src Tyrosine Kinase Activity (2003)

Tyrosine phosphorylation of the NR2A and NR2B subunits of the N-methyl-d-aspartate (NMDA) receptor by Src protein-tyrosine kinases modulates receptor channel activity and is necessary for the induction of long term potentiation (LTP). Deletion of H-Ras increases both NR2 tyrosine phosphorylation and NMDA receptor-mediated hippocampal LTP. Here we investigated whether H-Ras regulates phosphorylation and function of the NMDA receptor via Src family protein-tyrosine kinases. We identified Src as a novel H-Ras binding partner. H-Ras bound to Src but not Fyn both in vitro and in brain via the Src kinase domain. Cotransfection of H-Ras and Src inhibited Src activity and decreased NR2A tyrosine phosphorylation. Treatment of rat brain slices with Tat-H-Ras depleted NR2A from the synaptic membrane, decreased endogenous Src activity and NR2A phosphorylation, and decreased the magnitude of hippocampal LTP. No change was observed for NR2B. We suggest that H-Ras negatively regulates Src phosphorylation of NR2A and retention of NR2A into the synaptic membrane leading to inhibition of NMDA receptor function. This mechanism is specific for Src and NR2A and has implications for studies in which regulation of NMDA receptor-mediated LTP is important, such as synaptic plasticity, learning, and memory and addiction.
Finding your Way in the Fog (2014)

The cloud is migrating to the edge of the network, where routers themselves may become the virtualisation infrastructure, in an evolution labelled as "the fog". However, many other complementary technologies are reaching a high level of maturity. Their interplay may dramatically shift the information and communication technology landscape in the following years, bringing separate technologies into a common ground. This paper offers a comprehensive definition of the fog, comprehending technologies as diverse as cloud, sensor networks, peer-to-peer networks, network virtualisation functions or configuration management techniques. We highlight the main challenges faced by this potentially breakthrough technology amalgamation.
The <i>metD</i> <scp>d</scp> -Methionine Transporter Locus of <i>Escherichia coli</i> Is an ABC Transporter Gene Cluster (2002)

ABSTRACT The metD d -methionine transporter locus of Escherichia coli was identified as the abc - yaeE-yaeC cluster (now renamed metNIQ genes). The abc open reading frame is preceded by tandem MET boxes bracketed by the −10 and −35 boxes of a promoter. The expression driven by this promoter is controlled by the MetJ repressor and the level of methionine.
Clinical presentation of patients with "dyspepsia". Detailed symptomatic study of 360 patients. (1978)

This paper describes the clinical presentation of 360 patients suffering from "dyspepsia" at the time of their initial visit to two hospitals in Yorkshire. Disease categories studied were cholecystitis, duodenal ulcer, gastric ulcer, gastric cancer, and "functional" dyspepsia, with at least 50 patients in each category. The findings of this series are contrasted with "textbook" descriptions of these conditions. Some contrasts are quite surprising-for example, most of the 360 patients claimed that their pain was not aggravated by food. It is suggested that one reason for diagnostic error in this area of medicine is that clinicians have a faulty mental "database" of information with regard to the presentation of the various diseases concerned.
Association between management practices, dairy herd characteristics, and somatic cell count of bulk tank milk (1997)

Important factors associated with bulk tank milk SCC were prevalence of S agalactiae and S aureus mastitis, careful application of particular predip compounds, avoiding a dirty loose housing area, and use of a service to regularly monitor prevalence of mastitis in the herd.
Prevalence and Treatment Outcome of Primary and Secondary Fibromyalgia in Patients With Spinal Pain (1995)

Fibromyalgia is a disorder that occurs in a small proportion of patients with back pain. Fibromyalgia is not frequently recognized by referring physicians. In the authors' limited experience, patients with primary fibromyalgia appear to improve with conservative care. They have been less successful with those diagnosed as having secondary fibromyalgia.
Human mitochondrial tRNA modification and inherited encephalomyopathies (2006)

Mutations in human mitochondrial tRNA genes are responsible for a variety of human inherited diseases. Investigations of the molecular mechanisms of these diseases are of great interest for nowadays scientists. According to the study of post-transcriptional modification patterns of human mitochondrial tRNAs, novel taurine-containing modifications were identified at the anticodon wobble nucleotides of mitochondrial tRNA(Leu) (UUR) and tRNA(Lys). Recently, it was reported that mitochondrial tRNAs harboring one of those encephalomyopathies related mutations, such as A8344G, A3243G, T3271C etc., lacked the normal taurine-containing modification at their anticodon wobble positions. Wobble modification deficiencies of mutant mitochondrial tRNAs were found from cybrid cells, as well as from patient tissues. Molecular surgery experiments showed that the wobble modification is essential for the interaction between the anticodon in tRNA and the codon in mRNA. Furthermore, the enzyme that is responsible for the formation of the modification was identified and characterized. These studies strongly suggested a key molecular factor responsible for the inherited mitochondrial encephalomyopathies and could potentially lead to the development of a gene therapy for these diseases.
Wrangler (2011)

Though data analysis tools continue to improve, analysts still expend an inordinate amount of time and effort manipulating data and assessing data quality issues. Such "data wrangling" regularly involves reformatting data values or layout, correcting erroneous or missing values, and integrating multiple data sources. These transforms are often difficult to specify and difficult to reuse across analysis tasks, teams, and tools. In response, we introduce Wrangler, an interactive system for creating data transformations. Wrangler combines direct manipulation of visualized data with automatic inference of relevant transforms, enabling analysts to iteratively explore the space of applicable operations and preview their effects. Wrangler leverages semantic data types (e.g., geographic locations, dates, classification codes) to aid validation and type conversion. Interactive histories support review, refinement, and annotation of transformation scripts. User study results show that Wrangler significantly reduces specification time and promotes the use of robust, auditable transforms instead of manual editing.
Test-Enhanced Learning (2006)

Taking a memory test not only assesses what one knows, but also enhances later retention, a phenomenon known as the testing effect. We studied this effect with educationally relevant materials and investigated whether testing facilitates learning only because tests offer an opportunity to restudy material. In two experiments, students studied prose passages and took one or three immediate free-recall tests, without feedback, or restudied the material the same number of times as the students who received tests. Students then took a final retention test 5 min, 2 days, or 1 week later. When the final test was given after 5 min, repeated studying improved recall relative to repeated testing. However, on the delayed tests, prior testing produced substantially greater retention than studying, even though repeated studying increased students' confidence in their ability to remember the material. Testing is a powerful means of improving learning, not just assessing it.
Pycnophylactic interpolation revisited: integration with the dasymetric-mapping method (2010)

Dasymetric-mapping and pycnophylactic-interpolation methods have solid theoretical foundations and empirical supports in population-estimation research. Each of the methods has its own strengths, but also suffers obvious shortcomings. Dasymetric mapping makes good use of ancillary information to infer most likely population distribution, whereas it suffers from the unfounded assumption of uniform distribution of population among all eligible locations. Pycnophylactic interpolation warrants a smooth population surface in the study area without any presumption of uniform distribution. However, the method does not draw on information about real population distribution, so that its estimation accuracy cannot benefit from such useful information. In this paper, we develop a hybrid approach that takes advantage of the strengths and remedies the flaws of both methods. The hybrid method is tested with a case study. To evaluate the performance of the proposed hybrid method, this study compares its estimation accuracy with those of other popular methods including areal-weighting interpolation, binary dasymetric mapping and the pycnophylactic-interpolation method. The comparison results prove that the proposed hybrid method significantly outperforms the other methods. In addition, the study conducts a sensitivity analysis to examine the effect of search-radius size, which is the key parameter of the hybrid method, on estimation accuracy. The analysis result shows that the hybrid method can be further improved with appropriate choice of search radius.
Potato Tuber UDP-Glucose:Protein Transglucosylase Catalyzes Its Own Glucosylation (1992)

Potato (Solanum tuberosum L.) tuber UDP-glucose:protein transglucosylase (UPTG) (EC 2.4.1.112) is involved in the first of a two-step mechanism proposed for protein-bound alpha-glucan synthesis by catalyzing the covalent attachment of a single glucose residue to an acceptor protein. The resulting glucosylated 38-kilodalton polypeptide would then serve as a primer for enzymic glucan chain elongation during the second step. In the present report, we describe the fast protein liquid chromatography purification of UPTG from a membrane pellet of potato tuber. An apparently close association of UPTG, phosphorylase, and starch synthase was observed under native conditions during different purification steps. Enrichment of a 38-kilodalton polypeptide was found throughout enzyme purification. It is now shown that the purified UPTG, with an apparent molecular mass of 38 kilodaltons, undergoes self-glucosylation in a UDP-glucose- and Mn(2+)-dependent reaction. Therefore, it is concluded that UPTG is the enzyme and at the same time the priming protein required for the biogenesis of protein-bound alpha-glucan in potato tuber.
Licensed-Assisted Access to Unlicensed Spectrum in LTE Release 13 (2016)

Exploiting the unlicensed spectrum is considered by 3GPP as one promising solution to meet ever-increasing traffic growth. As a result, one major enhancement for LTE in Release 13 has been to enable its operation in the unlicensed spectrum via licensed-assisted access (LAA). In this article, we provide an overview of the Release 13 LAA technology including motivation, use cases, LTE enhancements for enabling the unlicensed band operation, and the coexistence evaluation results contributed by 3GPP participants.
A hierarchical hybrid fuzzy controller for real-time reverse driving support of vehicles with long trailers (1994)

A hierarchical hybrid fuzzy controller, consisting of higher level and lower level knowledge bases, that can be fuzzy or crisp, is employed for supporting continuous reverse driving of vehicles with long trailers. The controller is implemented in a prototype board with a commercially available microcontroller. The usefulness of this novel application could be successfully demonstrated by several experiments performed with a model truck and a long trailer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
3-O-.BETA.-D-Glucosyl-(1.RAR.6)-.BETA.-D-glucosyl-kaempferol Isolated from Sauropus androgenus Reduces Body Weight Gain in Wistar Rats (2006)

The young sticks and leaves of Sauropus androgynus (SA) that had been used as a health food for body weight reduction, led to an outbreak of obliterative bronchiolitis in Taiwan. This study tested the toxicity and anti-obesity features of the SA-isolated compound, 3-O-beta-D-glucosyl-(1-->6)-beta-D-glucosyl-kaempferol (GGK), on male Wistar rats receiving 6 or 60 mg/kg of GGK orally as well as partial purified EtOAc and n-BuOH fractions of SA extract daily for 28 d. Sixty milligrams per kilogram GGK treatment significantly reduced food intake in rats by 15% (p<0.05). The reduced food intake corresponded to decreases in body weight in the high or low dose GGK groups, as compared to the control groups. The serum levels of free triglyceride significantly decreased in GGK-treated rats. GGK treatment led to succesive reductions in daily food intake and body weight without obvious histopathological changes in Wistar rats. Thus, GGK may be potentially to be developed as a safe and novel compound for anti-obesity treatment.
Fatty Acid Composition within Each Structural Part and Section of a Soybean Seed (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFatty Acid Composition within Each Structural Part and Section of a Soybean SeedKeShun Liu, Edward A. Brown, and Frank OrthoeferCite this: J. Agric. Food Chem. 1995, 43, 2, 381–383Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/jf00050a023https://doi.org/10.1021/jf00050a023research-articleACS PublicationsRequest reuse permissionsArticle Views207Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Binding of 5H-Dibenzo[b,e][1,4]diazepine and Chiral 5H-Dibenzo[a,d]cycloheptene Analogs of Clozapine to Dopamine and Serotonin Receptors (1994)

5H-Dibenzo[b,e][1,4]diazepine, dibenz[b,f]oxepin, and 5H-dibenzo[a,d]cycloheptene analogues of clozapine [8-chloro-11-(4-methylpiperazino)-5H- dibenzo[b,e][1,4]diazepine] were evaluated for their binding affinity to dopamine D-1, D-2, and D-4 and serotonin S-2A (5-HT2A), S-2C (5-HT2C) and S-3 (5-HT3) receptors. The diazepine analogues display selective binding to the dopamine D-4 and serotonin S-2A receptors similar to that of clozapine, but none has a dopamine D-4 selectivity (Ki for the dopamine D-2A receptor/Ki for the dopamine D-4 receptor) greater than that of clozapine. All of the oxepin analogues also show substantial binding to the dopamine D-4 and serotonin S-2A receptors with 10-(4-methylpiperazino)dibenz[b,f]oxepin having a dopamine D-4 selectivity greater than that of clozapine. Some of the 5H-dibenzo-[a,d]cycloheptene analogues also show strong binding to both the dopamine D-4 and serotonin S-2A receptors, 5-methyl-10-(4-methylpiperazino)-5H-dibenzo[a,d]cycloheptene having a dopamine D-4 selectivity of 7.8 as compared to 10 for clozapine but a serotonin S-2A selectivity (Ki for the dopamine D-2 receptor/Ki for the serotonin S-2A receptor) of 2.0 as compared to 28 for clozapine. The serotonin S-2A selectivity of 2-chloro-10-(4-methylpiperazino)-5H-dibenzo[a,d]-cycloheptene++ + is 200. As an extension of these studies, chiral 5-substitute 10-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-5H-dibenzo[a,d]cyclohept ene analogues show a substantial enantiospecificity toward dopamine and serotonin receptor subtypes, (R)-(-)-5-methyl compound having a 2-fold higher dopamine D-4 selectivity than its (S)-(+) enantiomer as the result of enhanced binding to the dopamine D-4 receptor rather than diminished binding to the dopamine D-2 receptor. (pRa,pSb)-(+)-5-(2-Propylidene)-10-(1,2,3,6-tetrahydro-1-met hyl- 4-pyridinyl)-5H-dibenzo[a,d]cycloheptene is 17 times more active in binding to the dopamine D-4 receptor than is its pSa,pRb enantiomer while being only 1.5 times more active in binding to the dopamine D-2 receptor.
An olfactory demography of a diverse metropolitan population (2012)

These data provide a comprehensive snapshot of the olfactory sense of a diverse population. Olfactory acuity in the population is most strongly influenced by age, followed by gender. We also show a large number of diverse correlations between demographic factors and the perception of individual odours that may reflect genetic differences as well as different prior experiences with these odours between demographic groups.
Agent communication transfer protocol (2000)

Article Free Access Share on Agent communication transfer protocol Authors: Alexander Artikis Intelligent & Interactive Systems Group, Department of Electrical & Electronic Engineering, Imperial College of Science, Technology and Medicine, Exhibition Road, London, SW7 2BT, UK Intelligent & Interactive Systems Group, Department of Electrical & Electronic Engineering, Imperial College of Science, Technology and Medicine, Exhibition Road, London, SW7 2BT, UKView Profile , Jeremy Pitt Intelligent & Interactive Systems Group, Department of Electrical & Electronic Engineering, Imperial College of Science, Technology and Medicine, Exhibition Road, London, SW7 2BT, UK Intelligent & Interactive Systems Group, Department of Electrical & Electronic Engineering, Imperial College of Science, Technology and Medicine, Exhibition Road, London, SW7 2BT, UKView Profile , Christos Stergiou Intelligent & Interactive Systems Group, Department of Electrical & Electronic Engineering, Imperial College of Science, Technology and Medicine, Exhibition Road, London, SW7 2BT, UK Intelligent & Interactive Systems Group, Department of Electrical & Electronic Engineering, Imperial College of Science, Technology and Medicine, Exhibition Road, London, SW7 2BT, UKView Profile Authors Info & Claims AGENTS '00: Proceedings of the fourth international conference on Autonomous agentsJune 2000 Pages 491–498https://doi.org/10.1145/336595.337577Published:01 June 2000Publication History 6citation824DownloadsMetricsTotal Citations6Total Downloads824Last 12 Months30Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF