gebhart/patrepeval huggingface dataset:
Managing international manufacturing (1989)

Internationalisation of Manufacturing Base. Mapping International Factory Networks (K. Ferdows). International Manufacturing Strategies and Infrastructural Considerations in the Electronics Industry (M.E. McGrath, R.B. Bequillard). Global Manufacturing Rationalization: The Design and Management of International Factory Networks (M.D. Oliff, J.S. Arpan, F.L. Dubois). International Manufacturing and Distribution Networks: A Normative Model Framework (M.A. Cohen, M. Fisher, R. Jaikumar). International Sourcing: Beyond Catalog Shopping and Franchising (T. Flaherty). International Comparisons of Manufacturing Management. Overlapping Problem Solving in Product Development (K.B. Clark, T. Fujimoto). Closing the Competitive Gaps (J.G. Miller, A. Amano, A. De Meyer, K. Ferdows, J. Nakane, A. Roth). International Comparisons of Manufacturing Flexibility (D. Gerwin, J.-C. Tarondeau). International Manufacturing Strategies: A Comparative Analysis (A. Roth, A. De Meyer, A. Amano). Manufacturing and Global Competition. Learning, Productivity, and U.S.-Japan Industrial Competitiveness (M.B. Lieberman). The Money Game: New Pastime for Japanese Manufacturers? (E.W. Davis). Implications of CIM for International Manufacturing (J.D. Goldhar). International Comparisons of Approaches to Adaptation of Automated Manufacturing Technologies (J. Baranson).
The <i>gaf</i> Fimbrial Gene Cluster of <i>Escherichia coli</i> Expresses a Full-Size and a Truncated Soluble Adhesin Protein (2001)

The GafD lectin of the G (F17) fimbriae of diarrhea-associated Escherichia coli was overexpressed and purified from the periplasm of E. coli by affinity chromatography on GlcNAc-agarose. The predicted mature GafD peptide comprises 321 amino acids, but the predominant form of GafD recovered from the periplasm was 19,092 Da in size and corresponded to the 178 N-terminal amino acid residues, as judged by mass spectrometry and amino acid sequencing, and was named DeltaGafD. Expression of gafD from the cloned gaf gene cluster in DegP-, Lon-, and OmpT-deficient recombinant strains did not significantly decrease the formation of DeltaGafD. The peptide was also detected in the periplasm of the wild-type E. coli strain from which the gaf gene cluster originally was cloned. We expressed gafD fragments encoding C-terminally truncated peptides. Peptides GafD1-252, GafD1-224, GafD1-189, and the GafD1-178, isolated from the periplasm by affinity chromatography, had apparent sizes closely similar to that of DeltaGafD. Only trace amounts of truncated forms with expected molecular sizes were detected in spheroplasts. In contrast, the shorter GafD1-157 peptide was detected in spheroplasts but not in the periplasm, indicating that it was poorly translocated or was degraded by periplasmic proteases. Pulse-chase assays using gafD indicated that DeltaGafD was processed from GafD and is not a primary translation product. The DeltaGafD peptide was soluble by biochemical criteria and exhibited specific binding to GlcNAc-agarose. Inhibition assays with mono- and oligosaccharides gave a similar inhibition pattern in the hemagglutination by the G-fimbria-expressing recombinant E. coli strain and in the binding of [(14)C]DeltaGafD to GlcNAc-agarose. DeltaGafD bound specifically to laminin, a previously described tissue target for the G fimbria. Our results show that a soluble, protease-resistant subdomain of GafD exhibits receptor-binding specificity similar to that for intact G fimbriae and that it is formed when gafD is expressed alone or from the gaf gene cluster.
Interactive MRI-Guided Radiofrequency Interstitial Thermal Ablation of Abdominal Tumors: Clinical Trial for Evaluation of Safety and Feasibility (1999)

No AccessJournal of UrologyUrological Survey: Abstracts: Renal Tumors, Retroperitoneum, Ureter, and Urinary Diversion and Reconstruction1 Feb 1999Interactive MRI-Guided Radiofrequency Interstitial Thermal Ablation of Abdominal Tumors: Clinical Trial for Evaluation of Safety and Feasibility J.S. Lewin, C.F. Connell, J.L. Duerk, Y.-C. Chung, M.E. Clampitt, J. Spisak, G.S. Gazelle, and J.R. Haaga J.S. LewinJ.S. Lewin More articles by this author , C.F. ConnellC.F. Connell More articles by this author , J.L. DuerkJ.L. Duerk More articles by this author , Y.-C. ChungY.-C. Chung More articles by this author , M.E. ClampittM.E. Clampitt More articles by this author , J. SpisakJ. Spisak More articles by this author , G.S. GazelleG.S. Gazelle More articles by this author , and J.R. HaagaJ.R. Haaga More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62036-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Interactive MRI-Guided Radiofrequency Interstitial Thermal Ablation of Abdominal Tumors: Clinical Trial for Evaluation of Safety and Feasibility." The Journal of Urology, 161(2), p. 733 Departments of Radiology and Biomedical Engineering, University Hospitals of Cleveland and Case Western University, Cleveland, Ohio, and Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 161Issue 2February 1999Page: 733 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information J.S. Lewin More articles by this author C.F. Connell More articles by this author J.L. Duerk More articles by this author Y.-C. Chung More articles by this author M.E. Clampitt More articles by this author J. Spisak More articles by this author G.S. Gazelle More articles by this author J.R. Haaga More articles by this author Expand All Advertisement PDF downloadLoading ...
A new video laryngoscope (2004)

I read with great interest the correspondence on the use of a video-monitored laryngoscope to facilitate training in the correct method of applying cricoid pressure (Asai et al. Anaesthesia 2003; 58: 602–3). I agree with the assertion that use of a device that enables the view of the glottis to be displayed on a video screen is useful for teaching purposes. The principal drawback using the systems currently available is that the fibreoptics comes into contact with bodily secretions (such arrangements are disclosed in US patent 6354 993, published US patent application 2002/0022769, Japanese patent publication 2000–175867 and US patent application 2001/0023312). These options are expensive and therefore discourage blade disposability. They require sterilisation between uses and this limits the use of the equipment as a teaching adjunct. In more recent times, the use of disposable blades has become common in order to avoid sterilisation procedures between patients (US patent 5879 304). I have designed a novel disposable blade with the object of providing a laryngoscope blade that is capable of being used with a camera and suited to be made in a disposable form (Provisional Patent AU 2003902523). The invention provides a laryngoscope blade, including a blade body; a camera channel extending along the inside of the body of the blade; and a transparent cover located at the distal end of the blade for closing the end of the camera channel (2, 3). Display mounted on handle of laryngoscope. Video-assisted laryngoscopy. The camera channel and the transparent cover provide a sealed channel enabling selective insertion and removal of the camera into and from the channel. The transparent cover provides a window through which the camera may be used to view a region about the distal end of the blade. The camera is mounted in a tube small enough to fit into the camera channel. The camera tube houses a camera chip and a key system to ensure correct orientation of the camera following insertion. The blade includes an illumination means in the form of a bulb, a LED or a light guide. The blade body mounts onto a handle in the traditional manner. A display is mounted onto the handle, for displaying images received from the camera. The prototype used a liquid crystal display. The display is attached to the handle by a pivoting or swing arm, allowing rotation of the screen to increase visibility to the user. The handle houses batteries for powering the camera, the display and the means of illumination. The novel laryngoscope blade functions entirely normally when mounted on a standard laryngoscope handle. I believe that by overcoming the need for sterilizing the camera or fibreoptic element, by the use of a cheap disposable laryngoscope blade, video-monitored laryngoscopy should become a more practical proposition.
Immunogenicity and safety of concomitant administration of a measles, mumps and rubella vaccine (M-M-RvaxPro®) and a varicella vaccine (VARIVAX®) by intramuscular or subcutaneous routes at separate injection sites: a randomised clinical trial (2009)

ClinicalTrials.gov NCT00432523.
Real‐time DNA binding measurements of the ETSl recombinant oncoproteins reveal significant kinetic differences between the p42 and p51 isoforms (1994)

The sequence-specific DNA binding of recombinant p42 and p51 ETS1 oncoprotein was examined quantitatively to determine whether the loss of the Exon VII phosphorylation domain in p42 ETS1 or the phosphorylation of expressed Exon VII in p51 ETS1 had an effect on DNA binding activity. The kinetics of sequence-specific DNA binding was measured using real-time changes in surface plasmon resonance with BIAcore (registered trademark, Pharmacia Biosensor) technology. The real-time binding of p42 and p51 ETS1 displayed significant differences in kinetic behavior. p51 ETS1 is characterized by a fast initial binding and conversion to a stable complex, whereas p42 ETS1 exhibits a slow initial binding and conversion to a stable complex. All of the p51 ETS1 DNA binding states are characterized by rapid turnover, whereas the p42 ETS1 DNA binding states are 4-20 times more stable. A model describing these kinetic steps is presented. Stoichiometric titrations of either p42 or p51 ETS1 with specific oligonucleotides show 1:1 complex formation. The DNA sequence specificity of the p42 and p51 ETS1 as determined by mutational analysis was similar. The in vitro phosphorylation of p51 ETS1 by CAM kinase II obliterates its binding to specific DNA, suggesting that the regulation of p51 ETS1 sequence-specific DNA binding occurs through phosphorylation by a calcium-dependent second messenger. The p42 ETS1 lacks this regulatory domain (Exon VII), and binding to its specific DNA sequence is not sensitive to calcium signaling.
Antisense inhibition of protein phosphatase 2C accelerates cold acclimation in Arabidopsis thaliana (2001)

Two related protein phosphatases 2C, ABI1 and AtPP2CA have been implicated as negative regulators of ABA signalling. In this study we characterized the role of AtPP2CA in cold acclimation. The pattern of expression of AtPP2CA and ABI1 was studied in different tissues and in response to abiotic stresses. The expression of both AtPP2CA and ABI1 was induced by low temperature, drought, high salt and ABA. The cold and drought-induced expression of these genes was ABA-dependent, but divergent in various ABA signalling mutants. In addition, the two PP2C genes exhibited differences in their tissue-specific expression as well as in temporal induction in response to low temperature. To elucidate the function of AtPP2CA in cold acclimation further, the corresponding gene was silenced by antisense inhibition. Transgenic antisense plants exhibited clearly accelerated development of freezing tolerance. Both exposure to low temperature and application of ABA resulted in enhanced freezing tolerance in antisense plants. These plants displayed increased sensitivity to ABA both during development of frost tolerance and during seed germination, but not in their drought responses. Furthermore, the expression of cold-and ABA-induced genes was enhanced in transgenic antisense plants. Our results suggest that AtPP2CA is a negative regulator of ABA responses during cold acclimation.
VROOM: Virtual ROuters On the Move. (2007)

Network management is the proverbial “elephant in the room”—the pressing problem we all know is plaguing the Internet, yet seems intractable to solve. Each new management challenge leads to a new point solution, such as a new configuration script, measurement tool, or protocol extension. In this paper, we argue that many networkmanagement problems stem from the same root cause— the need to maintain consistency between the physical and logical configuration of routers. Instead, we believe that future networks should break this tight coupling by allowing (virtual) routers to freely move from one physical node to another, without changing the IP-layer topology. Our VROOM (Virtual ROuters On the Move) architecture supports live virtual router migration and re-mapping of virtual links, by capitalizing on recent innovations in programmable transport networks, packet-aware access networks, virtual server migration and virtual router technologies. Preliminary experiments with a simple prototype, built using Xen and the Linux routing software, show that VROOM is feasible in practice. We believe that virtual router migration will simplify a variety of networkmanagement tasks, including planned maintenance, service deployment, and minimizing power consumption. 1.
Advanced gate control system for power MOSFET switching losses reduction with complete switching sequence control (2016)

To meet strict EMC requirements for power electronics applications driving an inductive load, it is often necessary to mitigate current and voltage transition slopes. Using the conventional MOSFET control method, slope mitigation is commonly performed by modifying a series gate resistance, which results in high switching losses, long turn-on and turn-off delays and long final gate charging and discharging durations affecting the overall application efficiency. In order to improve this, a novel MOSFET control method is developed and presented in this paper. It enables a complete control over all intervals of the switching sequences utilizing the gate current shaping principle. Switching losses, delays and final gate charging and discharging durations can be kept as low as possible, as the method allows to mitigate only the critical transition. The design of the system allows its implementation in a broad spectrum of applications regardless of the current or voltage rating and with a minimal impact on the application design. The paper first presents the inductive load switching background, followed by the detailed description of the presented system operation and its realization as an integrated circuit. At the end, efficiency measurements of the conventional and the advanced gate control methods are reported, showing significant advantages of the proposed system.
White organic light emitting diodes with enhanced internal and external outcoupling for ultra-efficient light extraction and Lambertian emission (2012)

White organic light emitting diodes (WOLEDs) suffer from poor outcoupling efficiencies. The use of Bragg-gratings to enhance the outcoupling efficiency is very promising for light extraction in OLEDs, but such periodic structures can lead to angular or spectral dependencies in the devices. Here we present a method which combines highly efficient outcoupling by a TiO(2)-Bragg-grating leading to a 104% efficiency enhancement and an additional high quality microlens diffusor at the substrate/air interface. With the addition of this diffusor, we achieved not only a uniform white emission, but also further increased the already improved device efficiency by another 94% leading to an overall enhancement factor of about 4.
Differential effects of CpG‐DNA in Toll‐like receptor‐2/‐4/‐9 tolerance and cross‐tolerance (2005)

Lipopolysaccharide (LPS) tolerance is a state of refractoriness towards a second stimulation by LPS after a preceding stimulation. LPS is recognized by Toll-like receptor-4 (TLR-4), which belongs to a group of pattern recognition receptors mediating activation of innate immunity by microbial components. To date, it is not known in detail to what extent other TLR-dependent stimuli also induce tolerance and whether preceding and challenging stimuli are interchangeable. We have examined tolerance induction in detail for lipoteichoic acid (LTA), LPS and CpG-DNA, which are recognized by TLR-2, -4 and -9, respectively. In RAW264.7 macrophages, all three stimuli induced tolerance towards a subsequent challenge with the same stimulus used for priming, as well as cross-tolerance towards subsequent challenge with other stimuli signalling via different TLRs. However, whereas LPS/LTA cross-tolerance was also functional in an in vivo model of galactosamine (GalN)-primed liver damage, pretreatment with CpG only protected against GalN/CpG challenge and failed to induce cross-tolerance for LPS and LTA. CpG-DNA pretreatment even enhanced tumour necrosis factor (TNF)-alpha production and liver damage upon subsequent challenge with LPS or LTA. Stimulation with CpG-DNA resulted in a peculiar sensitization for interferon (IFN)-gamma secretion. The data indicate that, in contrast to in vitro macrophage desensitization, the in vivo consequences of repeated TLR stimulation greatly differ amongst different TLR ligands.
Modeling Identity in Archival Collections of Email: A Preliminary Study. (2006)

Access to historically significant email archives poses challenges that arise less often in personal collections. Most notably, searchers may need help making sense of the identities, roles, and relationships of individuals that participated in archived email exchanges. This paper describes an exploratory study of identity resolution in the public subset of the Enron collection. Addressname and address-address associations in explicit, embedded and implied email headers are augmented with name and nickname associations discovered from consistent use in salutations and signatures. Limited transitive closure heuristics are employed to extend pair-wise associations to richer representations of identity. Assessment of sampled results indicates that many potentially useful nontrivial associations can be detected. 1.
Inhibition of Membrane-Type Serine Protease 1/Matriptase by Natural and Synthetic Protease Inhibitors (2003)

Membrane-type serine protease 1 (MT-SP1), identical to matriptase, is a recently identified type II transmembrane serine protease. MT-SP1/matriptase is of considerable interest for the development, homeostasis, and cancer invasion and metastasis of epithelial tissues. The administration of inhibitors for MT-SP1/matriptase may be effective to suppress the development of tumors where the enzyme may be involved. In the present study, we produced a secreted form of recombinant MT-SP1/matriptase (ekMT-SP1s) that can be activated by enterokinase in vitro and investigated the inhibitory ability of various protease inhibitors toward the recombinant enzyme. The enterokinase-treated ekMT-SP1s (active ekMT-SP1s) cleaved various peptidyl-4-methylcoumaryl-7-amide (MCA) substrates with arginine (or lysine) residue at position P1, and the best substrate was t-butyloxycarbonyl (Boc)-Gln-Ala-Arg-MCA. The specificity for the synthetic and natural substrates of the active ekMT-SP1s was in good agreement with that of the natural enzyme. Endogenous protease inhibitors tested, except for antithrombin III, showed no or little inhibition on the cleavage of Boc-Gln-Ala-Arg-MCA by the active ekMT-SP1s. Aprotinin showed strong inhibitory activity toward the cleavage. Food-derived inhibitors, such as soybean trypsin inhibitor, Bowman-Birk inhibitor, and lima bean trypsin inhibitor inhibited it, while chicken ovomucoid did not. Synthetic inhibitors tested inhibited it, and among them, the inhibitory effect of FOY-305 was strongest. The present findings provide important information for the suppression of cancer invasion and metastasis for which MT-SP1/matriptase is responsible.
Real-time automatic target tracking based on spatio-temporal gradient method with generalized least square estimation (2003)

The result of a spatio-temporal gradient (STG) method with generalized least square estimation (GLSE) is presented for the detection of an object motion in an image sequence corrupted by additive white noise. The proposed method is applied to an automatic target tracker using a high speed 16-bit microprocessor in order to track one moving target in real time. Experimental results show that the proposed method has much better performance over the conventional one with least square estimation (LSE).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Caracteres da experiência (2001)

Abstract The discrimination between two points of view, or perspectives, in respect to consciousness, one on the first-person other on the third-person, deals with two concepts of consciousness- respectively, phenomenal consciousness and intentional consciousness (sections 1 and 2). I will accept, generally, this idea. However, I will argue that are not two, but three kinds of consciousness and typ of experience, making my point introducing the concept of different characters of experience (section 3). These characters are ‘experience’, ‘signification’ and ‘reference/object’, and when all of them occur I say that we have an intentional experience. If it lacks the last one, we have a meaningful experience, but without reference. Finally, if the only occurrence is ‘experience’, then the type of experience we live is a meaningless or mute experience. This ‘taxonomy’ allows classifying a perceptum as an intentional experience, a quale as a meaningful experience and a sense datum as a mute experience. On the other hand, it represents, as I claim, an approach much more clear, than those usually appears, to the question ‘what qualia really are? ‘ (sections 4 e 5). Moreover: it makes possible talk about objectivity of qualia, an objectivity without object (section 6).
The fractional fourier transform and the wigner distribution (1996)

Abstract The Wigner distribution and many other members of the Cohen class of generalized phase-space distributions of a signal all share certain translation properties and the property that their two marginal distributions of energy density along the time and along the frequency axes equal the signal power and the spectral energy density. A natural generalization of this last property is shown to be a certain relationship through the Radon transform between the distribution and the signal's fractional Fourier transform. It is shown that the Wigner distribution is now distinguished by being the only member of the Cohen class that has this generalized property as well as a generalized translation property. The inversion theorem for the Wigner distribution is then extended to yield the fractional Fourier transforms.