gebhart/patrepeval huggingface dataset:
Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies (2005)

It has been possible to demonstrate that 17-AAG exhibits a tolerable toxicity profile with therapeutic plasma concentrations and target inhibition for 24 hours after treatment and some indications of clinical activity at the dose level 450 mg/m(2)/week. We recommend this dose for phase II clinical trials.
Introduction (2007)

A young woman starts her first period in the school shower and mistakenly thinks she is bleeding to death — her mother having kept her ignorant of female biology in the equally ignorant belief that she can keep her as a 'sinless' child forever. Taunted by the other schoolgirls around her, slapped and shouted at by her gym teacher to 'grow up', she focuses her anger and frustration on making a light bulb explode overhead, causing everyone to hush...KeywordsMoral ResponsibilityFemale CharacterFairy TaleFolk TaleFemale ProtagonistThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Methicillin-resistant<i>Staphylococcus aureus</i>diagnostics: state of the art (2012)

Given the predilection of Staphylococcus aureus to modify its genetic characteristics, thereby enabling the species to stay one step ahead of laboratory detection systems, phenotypic methods for detection of antibiotic resistance mechanisms, especially those directed against the beta-lactam family, will continue to be required, in some situations, for the foreseeable future. Molecular methods are now the gold standard for surveillance, yielding higher sensitivity than the slower, culture-based methods. The newer molecular surveillance methods for detecting methicillin-resistant S. aureus (MRSA) colonization and for rapid and accurate identification of S. aureus from growth in culture systems have revolutionized patient care, enabling rapid interventions that lead to better individual patient outcomes, such as fewer postsurgical site infections, and better overall institutional infection control (fewer healthcare-associated MRSA infections).
Development and validation of stability indicating reversed-phase hplc method for the determination of ezetimibe in pharmaceutical dosage forms (2010)

In the present study, a simple, rapid and precise liquid chromatographic method was developed and validated for the determination of ezetimibe in its dosage form. The Ezetimibe was separated in a 100 x 4.6 mm i.d., C18 column, 3 μm particle sizes, Luna phenomenex, using a mobile phase composition of water and acetonitrile (60:40 v/v). Column oven temperature was kept at 25°C.The flow rate was 1.5 mL/min and the analyte monitored at 225 nm. The retention time of Ezetimibe was 8.47 min. The specificity of the method was determined by assessing interference from the placebo and by stress testing of the drug (forced degradation).The developed method was validated in terms of linearity, accuracy, precision, system suitability, limit of detection, limit of quantitation and solution stability. The proposed method was also applied successfully to the pharmaceutical dosage form self emulsified drug delivery without any interference by excipients.
Fiber Optic Sensor for High-Sensitivity Salinity Measurement (2013)

A highly sensitive salinity sensor based on a two-core optical fiber is demonstrated for both high- and low-concentration regimes. Salinity of several aqueous solutions is measured in the ranges from 0 to 5 mol/L and from 0 to 1 mol/L with sensitivities of 14.0086 and 12.0484 nm/(mol/L), respectively. The achieved sensitivity is ~19 times higher than that recently reported for polymide-coated photonic crystal fibers.
Creating entirely textured 3D models of real objects using surface flattening (2005)

Sexually transmitted diseases (STDs) are the most common infectious diseases worldwide, with over 350 million new cases occurring each year, and have far-reaching health, social, and economic consequences. Failure to diagnose and treat STDs at an early stage may result in serious complications and sequelae. STDs are passed from person to person primarily by sexual contact and are classified into varied groups. Some cause mild, acute symptoms and some are life-threatening. They are caused by many different infectious organisms and are treated in different ways. Syphilis and gonorrhea are ancient afflictions. Now, however, Chlamydia is prevalent and has become the most common bacterial STD. Antimicrobial resistance of several sexually transmitted pathogens is increasing, rendering some regimens ineffective, adding to therapeutic problems. A standardized treatment protocol for STDs is recommended to ensure that all patients receive adequate treatment. Appropriate treatment of STDs is an important public health measure.
Dynamag Ion Source with Open Cylindrical Extractor (1967)

A description is given of a duoplasmatron type ion source which features a novel, open cylindrical extractor electrode, a visible arc chamber and a short-path magnetic circuit. The glass spacer in the arc chamber permits observation of the plasma and filaments. The short magnetic circuit gives high plasma density at low magnet and arc currents. The open extraction geometry provides high pumping speed to the source and reasonable tolerances for anode alignment. Above a critical value of extraction voltage the ion emission is independent of voltage. At 16 kV, a 5 mA beam of mixed hydrogen ions can be obtained through an 0.008 in. anode aperture. Gas consumption is about 5 atm.-cc/ hr. with a conversion efficiency of about 70%. Proton yield is usually better than 50% of the total beam current under these conditions. The emittance (phase space area) is about 3 mrad.-cm. MeV½ at 1.0 mA.
CAD Data Representations for Haptic Virtual Prototyping (1997)

Abstract For many years designers have relied on visual feedback and two-dimensional pointing devices to interact with Computer-Aided Design (CAD) models. The “sense of touch”, that is fundamental to interaction and manipulation in everyday life, is not yet a part of the standard human-computer interface. An on-going project at the Ford Research Laboratory has created an immersive virtual prototyping system with which a designer can not only visualize a CAD model but also “touch” it using a force-feedback device. This paper will briefly introduce human perception of haptic information and then describe the process of haptically rendering an object. Then the issues involved with the correct selection of a data representation for haptic rendering will be addressed. Lastly, a brief description of the experimental system implemented at the Ford Research Laboratory will be given.
Lipid coated chitosan microparticles as protein carriers (2011)

Abstract In this study, a novel protein‐loaded and lipid‐coated drug carrier system for pulmonary application was developed. In a first step, spherically shaped chitosan particles were produced by spray‐drying. The produced particles showed sizes between 2 μm and 3.5 µm and zeta potentials ranged between 1.4 mV and 37.9 mV. Due to the positive charge of the particles, they could easily be loaded with the model protein drug Bovine Serum Albumine (BSA) via electrostatic interaction. In a final step, the prepared BSA loaded chitosan microparticles were coated with a lipid layer to improve drug delivery via the pulmonary and nasal route. This lipid‐based surface modification changed the physico‐chemical characteristics of the drug carrier systems. While unmodified chitosan particles showed a fast burst release of the protein, the lipid coated particles released the protein over a time period of 2 days. In Conclusion, the lipid‐coated particles show characteristics which make them a promising vehicle for pulmonary administration of proteins. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The role of DCN in optical WDM networks (2002)

With the recent advances in WDM networking technology, and the growing deployment of WDM networking equipment, we are now witnessing the establishment of the next generation networking infrastructure. This paper briefly reviews the role of the data communication network (DCN) in transport networks, and describes MONET's DCN architecture. We then describe a new signalling application of the DCN for WDM-based networks.
Multimedia support to stormwater pump operation (2002)

Stormwater pump operation at the time of urban storms is so difficult that it depends on operators' heuristics. For the operators, understanding of the current status is essential. However, current monitoring systems treating restricted areas by conventional numerical sensors, are insufficient. To support secure and reliable pump operation against urban floods, we have applied multimedia technologies to wide-area monitoring with vivid and fine-grained information. In this paper, we describe the features of the multimedia monitoring system for the stormwater pump operation, as follows: (1) wide-area monitoring, (2) automatic alarm using live videos, (3) prediction of inflow into pumping stations, and (4) multimedia playback.
Perioperative dynamics and significance of amino acid profiles in patients with cancer (2015)

PFAA patterns in cancer patients are altered perioperatively. Tumor-related amino acids identified by dynamic study of PFAA patterns may have the potential to be developed as novel biomarkers for diagnosis and prognosis of cancer patients.
LcrV Delivered via Type III Secretion System of Live Attenuated Yersinia pseudotuberculosis Enhances Immunogenicity against Pneumonic Plague (2014)

Here, we constructed a Yersinia pseudotuberculosis mutant strain with arabinose-dependent regulated and delayed shutoff of crp expression (araC P(BAD) crp) and replacement of the msbB gene with the Escherichia coli msbB gene to attenuate it. Then, we inserted the asd mutation into this construction to form χ10057 [Δasd-206 ΔmsbB868::P(msbB) msbB(EC) ΔP(crp21)::TT araC P(BAD) crp] for use with a balanced-lethal Asd-positive (Asd(+)) plasmid to facilitate antigen synthesis. A hybrid protein composed of YopE (amino acids [aa]1 to 138) fused with full-length LcrV (YopE(Nt138)-LcrV) was synthesized in χ10057 harboring an Asd(+) plasmid (pYA5199, yopE(Nt138)-lcrV) and could be secreted through a type III secretion system (T3SS) in vitro and in vivo. Animal studies indicated that mice orally immunized with χ10057(pYA5199) developed titers of IgG response to whole-cell lysates of Y. pestis (YpL) and subunit LcrV similar to those seen with χ10057(pYA3332) (χ10057 plus an empty plasmid). However, only immunization of mice with χ10057(pYA5199) resulted in a significant secretory IgA response to LcrV. χ10057(pYA5199) induced a higher level of protection (80% survival) against intranasal (i.n.) challenge with ~240 median lethal doses (LD50) (2.4 × 10(4) CFU) of Y. pestis KIM6+(pCD1Ap) than χ10057(pYA3332) (40% survival). Splenocytes from mice vaccinated with χ10057(pYA5199) produced significant levels of gamma interferon (IFN-γ), tumor necrosis factor alpha (TNF-α), and interleukin-17 (IL-17) after restimulation with LcrV and YpL antigens. Our results suggest that it is possible to use an attenuated Y. pseudotuberculosis strain delivering the LcrV antigen via the T3SS as a potential vaccine candidate against pneumonic plague.
Spatial database access methods (1991)

In the discussion of research issues in spatial databases (SIGMOD Record vol. 19, no. 4, Dec 1990) we stated the need for a robust framework for analytical comparison of a broad range of spatial access methods. The utility of such a comparison, even of very closely related access methods, was shown in [FALO87]. A necessary precondition for a meaningful analytical comparison is the existence of strong analytical results for individual access methods. In the following paper, Salzberg and Lomet take the worst case analytical results on fan-out and average storage utilization they obtained for their hB-tree [LOME89,LOME90] and extend the analysis to another robust method, Z-order encoding [OREN84]. We think this paper is a start on the comparative assessment of access methods based on analytical results. We hope to see future work extend the framework beyond worst case analysis, and to other access methods as well.
High-speed separation system of randomly suspended single living cells by laser trap and dielectrophoresis (2001)

We developed a new system for random separation of a single microorganism, such as a living cell and a microbe, in the microfluidic device under the microscope by integrating the laser-trapping force and dielectrophoretic (DEP) force. An arbitrarily selected single microbe could be isolated in a microchannel, despite the presence of a large number of microbes in solution. Once the target microbe is trapped at the focal point of the laser, we can easily realize exclusion of excess microbes around the target by controlling the electric field, while keeping the target trapped by the laser at the focal point. To realize an efficient separation system, we proposed a new separation cell and produced it by microfabrication. Flow speed in the microchannel is adjusted and balanced to realize high-speed and high-purity extraction of the target. Some preliminary experiments are conducted to show the effectiveness. The target is trapped by the laser, transported, and is taken out from the extraction port. Total separation time is less than 20 s. Our method is extremely useful in the pure cultivation of the cell and will be a promising method for biologists in screening useful microbes.
Preparation and Photovoltaic Properties of Lead Lanthanum Zirconate Titanate in Design of Multilayers (2005)

In this paper, we report on the formation of multilayer structures and the highly improved photovoltaic output current of the lead lanthanum zirconate titanate (PLZT) film employed. The photovoltaic effect of ferroelectrics has the advantage of simple mechanisms of nonbias applications, which are indispensable for semiconductor p-n junctions. However, the output current of PLZT bulk is too low for use as a device current source. The new design is described using an upper transparent indium tin oxide (ITO) electrode. The PLZT film structure exhibits a µA output current upon light illumination. The photovoltaic current of the PLZT film is more than 10 2 times that of the bulk PLZT. These differences are due to the characteristics of the design of multilayers including the configuration of the electrode. The PLZT film also has the advantages of easy output control and suitability for use on a Si substrate. A simple model is used for an illustrative explanation of the improved photovoltaic effect of the PLZT film. Results show that the photovoltaic effect of the ferroelectric multilayer is useful as the current source for a micro-electro-mechanical system (MEMS).
Tailoring the Separation Behavior of Hybrid Organosilica Membranes by Adjusting the Structure of the Organic Bridging Group (2011)

Abstract Hybrid organically linked silica is a highly promising class of materials for the application in energy‐efficient molecular separation membranes. Its high stability allows operation under aggressive working conditions. Herein is reported the tailoring of the separation performance of these hybrid silica membranes by adjusting the size, flexibility, shape, and electronic structure of the organic bridging group. A single generic procedure is applied to synthesize nanoporous membranes from bridged silsesquioxane precursors with different reactivities. Membranes with short alkylene (CH 2 and C 2 H 4 ) bridging groups show high H 2 /N 2 permeance ratios, related to differences in molecular size. The highest CO 2 /H 2 permeance ratios, related to the affinity of adsorption in the material, are obtained for longer (C 8 H 16 ) alkylene and aryl bridges. Materials with long flexible alkylene bridges have a hydrophobic surface and show strongly temperature‐dependent molecular transport as well as a high n ‐butanol flux in a pervaporation process, which is indicative of organic polymerlike properties. The versatility of the bridging group offers an extensive toolbox to tune the nanostructure and the affinity of hybrid silica membranes and by doing so to optimize the performance towards specific separation challenges. This provides excellent prospects for industrial applications such as carbon capture and biofuel production.
Four-kilobase sequence of the mouse CNP gene directs spatial and temporal expression of lacZ in transgenic mice (1998)

The gene encoding 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin genes to be expressed in the brain. It is expressed at basal levels in some non-neural tissues but at much higher levels in the nervous system, and its relevance and mechanism are unknown. Using transgenic mice, we examined the expression pattern conferred by a 4-kilobase (-kb) 5'-flanking sequence of the mouse CNP gene coupled to the bacterial lacZ reporter gene. Here we report that this 4-kb fragment contains sufficient information to direct expression of the transgene to the tissue and/or cell type, in which CNP is normally expressed. In the central nervous system (CNS), CNP-lacZ expression was regulated in a temporal manner, consistent with endogenous CNP expression. Transgene expression was detected in embryonic brain and spinal cord in immature oligodendrocytes, and it significantly increased with age. In adult mice, beta-galactosidase activity (which appeared to be oligodendrocyte specific) was found essentially in white matter areas of the CNS. Moreover, the transgene was expressed in peripheral nervous system, testis, and thymus-tissues that normally express CNP. Taken together, our results provide strong evidence that cis-acting regulatory elements, necessary to direct spatial and temporal expression of the transgene in oligodendrocytes, are located within the 4-kb 5'-flanking sequence of the mouse CNP gene. This promoter could be a valuable tool to target specific expression of other transgenes to oligodendrocytes, and may provide important new insights into myelination or dysmyelination.
The Influence of Soya Lecithin on Muscular Strength (1951)

(1951). The Influence of Soya Lecithin on Muscular Strength. Research Quarterly. American Association for Health, Physical Education and Recreation: Vol. 22, No. 2, pp. 201-207.
Acritarch Evidence for an Ediacaran Adaptive Radiation of Fungi (2015)

Acritarchs are problematic organic-walled microfossils, traditionally regarded as phytoplankton, but also as cysts of metazoans or mesomycetozoans, and fungi. This review develops criteria for distinguishing these alternatives, and documents fungal features in several Precambrian acritarchs: (1) irregular shape, (2) hyphal attach ment, (3) spherical wall protrusions, (4) septate and fused hyphae, (5) multilayered brittle walls that split and detach, (6) large size (>100 m), and (7) chitin and chitosan composition revealed by FTIR. Large acritarchs with fungal features are common and diverse during the Ediacaran, at the same time as extinct lichenlike Vendobionta. A different assemblage of small acritarchs diver sified with the Cambrian evolutionary explosion of algae and metazoans. A fos sil record of glomeromycotan fungi back to the Paleoproterozoic (2200 Ma) supports the idea of fungal life on land long before land plants, and an amended version of Pirozynski and Malloch's mycotrophic origin of early land plants. K e y w o r d s : acritarch, Ediacaran, Glomeromycota, FTIR, wall ultrastructure .. . - c , , , . : (1) , (2) (3) , (4) (5) (6) (> 100 ) (7) , . , . . (2200 ) , .
Neurologische, psychiatrische und testpsychologische Befunde nach der Behandlung von hirneigenen Tumoren (1968)

46 Patienten wurden im Durchschnitt 4,4 Jahre nach operativer Behandlung eines hirneigenen Tumors in einheitlicher Weise neurologisch, psychiatrisch und testpsychologisch untersucht. Bei keinem Patienten waren zum Zeitpunkt der Befunderhebung Zeichen eines Tumorrezidivs nachweisbar. Die Ergebnisse der Testuntersuchungen wurden mit denen einer nach Alter und Geschlecht vergleichbaren Kontrollgruppe von 86 neuropsychiatrisch unauffälligen Probanden verglichen.
Nanocomposite Coatings: Preparation, Characterization, Properties, and Applications (2018)

Incorporation of nanofillers into the organic coatings might enhance their barrier performance, by decreasing the porosity and zigzagging the diffusion path for deleterious species. Thus, the coatings containing nanofillers are expected to have significant barrier properties for corrosion protection and reduce the trend for the coating to blister or delaminate. On the other hand, high hardness could be obtained for metallic coatings by producing the hard nanocrystalline phases within a metallic matrix. This article presents a review on recent development of nanocomposite coatings, providing an overview of nanocomposite coatings in various aspects dealing with the classification, preparative method, the nanocomposite coating properties, and characterization methods. It covers potential applications in areas such as the anticorrosion, antiwear, superhydrophobic area, self-cleaning, antifouling/antibacterial area, and electronics. Finally, conclusion and future trends will be also reported.
The Effect of Time Limits on Performance of Mental Rotations by Gifted Adolescents (1992)

The mental rotation skill of mathematically talented male and female adolescents was measured with an altered test administration procedure so that students could complete the test after the time limit expired. This procedure was used to compare performance under traditional timed test conditions and conditions in which the effects of time on performance were minimized. A significant difference was found favoring males in both conditions. A comparison between Timed and Composite scores, however, showed that the male advantage decreased substantially when the effect of time was minimized.
Improvements in computing multiple phase flows (1997)

of the Dissertation Improvements in Computing Multiple Phase Flows by Brian James Miller Doctor of Philosophy in Mathematics University of California, Los Angeles, 1997 Professor Stanley Osher, Chair Improvements are made to a level set method for solving the incompressible, immiscible Navier-Stokes equations for fluids separated by an interface. A variable density projection method combined with a TVD Runge-Kutta scheme is used to advance the computed solution in time. The improvements allow the method to be applied in three dimensions without difficulty, give more freedom in choosing boundary conditions, and enable the application of new fast solver techniques. The use of the level set formulation allows easy treatment of merging and breaking flows. We examine typical problems such as air bubbles in water and water drops in air. Comparisons are made with other numerical methods and with theoretical results. ix CHAPTER 1 Introduction In this presentation, we will develop improve...