gebhart/patrepeval huggingface dataset:
MORPHOLOGICAL AND FUNCTIONAL RELATIONS OF GRAAFIAN FOLLICLE GROWTH TO OVULATION IN WOMEN USING ULTRASONIC, LAPAROSCOPIC AND BIOCHEMICAL MEASUREMENTS (1981)

The daily growth rates of ovarian follicles were recorded ultrasonically for five days until ovulation in 56 spontaneously ovulating women and related to endocrine and clinical parameters. Over the 5-day period, the average diameter of the follicle destined to ovulate increased from 12 to 23 mm, the second largest follicle from 6 to 12 mm, the third largest follicle from 5 to 9 mm and the fourth largest follicle from 4 to 8 mm. Similar but lesser growth rates occurred in the follicles in the contralateral ovary. Ovulation occurred within 24 hours of the luteinizing hormone (LH) peak, and the mean peak diameter of the ovulating follicle was 23.2 +/- 0.3 (SEM) mm, (range 18-29 mm) before ovulation, and subsequent luteal function was judged to be normal. Follicular growth was most closely correlated with increasing peripheral blood oestrogen levels. In 16 women who had a laparoscopy within 12 hours of the last ultrasound and following the LH peak, the mean diameter of the largest follicle as measured by ultrasound (23.6 +/- 0.4 mm) was similar to that measured at laparoscopy (22.8 +/- 0.04 mm) and estimated from the volume of follicular fluid aspirated (average 5.8 +/- 0.2 ml), 22.5 mm. The follicular fluid levels of progesterone were high on the day of the LH peak and blood progesterone levels had risen significantly indicating that luteinization of the dominant Graafian follicles had already occurred prior to ovulation. This study confirms that ultrasonic monitoring provides a reliable measure of follicular growth and allows studies correlating morphological changes with both normal and abnormal endocrine function of the human ovary.
The Principal's Duties (1931)

Dividing the principal's activities into organization, social, administrative, and supervisory Mr. Kirby urges that 70 per cent. of the executive's day be given to supervision: He describes a technique for improving instruction.
Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. (1990)

Histamine is a neurotransmitter in the central nervous system and an important modulator of gastric acid secretion, vasomotor control, inflammation, and allergic reactions. In biological systems the formation of histamine from its precursor histidine is catalyzed by the enzyme L-histidine decarboxylase (HDC; L-histidine carboxy-lyase, EC 4.1.1.22). We have cloned HDC-encoding cDNA from a fetal rat liver cDNA library (phage lambda gt11) have deduced the amino acid sequence from the nucleotide sequence. The clone was proven to be HDC cDNA by expression of active recombinant enzyme in COS cells and by chromosomal mapping. The cDNA encodes a protein of Mr 73,450 (655 amino acid residues). The discrepancy between this molecular weight and the size of the purified fetal liver protein subunits [Taguchi, Y., Watanabe, T., Kubota, H., Hayashi, H. & Wada, H. (1984) J. Biol. Chem. 259, 5214-5221] (Mr = 54,000) suggests that HDC may be posttranslationally processed. The 469 amino acid residues from the amino-terminal portion of the protein share 50% identity with rat and Drosophila L-dopa decarboxylases and much less homology with other characterized amino acid decarboxylases.
Recombinant tissue plasminogen activator in patients with pulmonary embolism: correlation of fibrinolytic specificity and efficacy. (1987)

Blood samples from 24 patients who received recombinant human tissue-type plasminogen activator (rt-PA) for angiographically documented acute pulmonary embolism were examined to identify and quantify fibrinolysis. Before and after the intravenous administration of 50 mg rt-PA over a 2 hr period, levels of total fibrinogen, fibrin(ogen) degradation products (FDP), and cross-linked fibrin degradation products (XDP) were measured in each patient. Elevated levels of XDP were found in all patients before treatment (mean 2.0 micrograms/ml, normal less than 0.2 microgram/ml), and these increased 12-fold with treatment. Fibrinogen levels fell 30% and FDP levels increased 24-fold for the entire group of patients. Over this 2 hr period, 10 of 24 patients (responders) demonstrated 25% or greater improvement in the extent of pulmonary artery thrombus as quantified by Urokinase Pulmonary Embolism Trial score, and these patients were found to have a significantly lower XDP/FDP ratio after rt-PA (p less than .04) than those patients who failed to respond. These data suggest that the intravenous administration of pharmacologic doses of rt-PA in patients with pulmonary embolism produces both fibrinolysis and fibrinogenolysis, successful thrombolysis in these patients is associated with a preponderance of fibrinogenolysis over fibrinolysis, the XDP/FDP ratio is a useful indicator of fibrinolytic specificity, and in patients with acute pulmonary embolism the endogenous fibrinolytic pathways are activated, albeit ineffectively, as indicated by the increased circulating XDP levels seen in all 24 patients before the administration of rt-PA.
A single user multiprocessor incorporating processor manipulation facilities (1980)

A single user general purpose multiprocessor computing system developed around a high level language is described. Both the hardware configuration and its relation to the accompanying software are discussed. The multiprocessor presented is designed for the single user; commonly used techniques such as time-sharing, swapping and user protection are discarded. The system provides a mechanism in the language for the separation of process and processor, and enables a description of some characteristics of the latter. A PROCESSOR type is introduced in the language that corresponds exactly to hardware processing elements, and it is shown that by being able to manipulate items of this type, a versatile computer and research tool is developed which enables further investigation into synchronisation protocols and interconnection techniques.
Polyglutamine-mediated dysfunction and apoptotic death of a <i>Caenorhabditis elegans</i> sensory neuron (1999)

The effect of expressing human huntingtin fragments containing polyglutamine (polyQ) tracts of varying lengths was assessed in Caenorhabditis elegans ASH sensory neurons in young and old animals. Expression of a huntingtin fragment containing a polyQ tract of 150 residues (Htn-Q150) led to progressive ASH neurodegeneration but did not cause cell death. Progressive cell death and enhanced neurodegeneration were observed in ASH neurons that coexpressed Htn-Q150 and a subthreshold dose of a toxic OSM-10::green fluorescent protein (OSM-10::GFP) fusion protein. Htn-Q150 huntingtin protein fragments formed protein aggregates in ASH neurons, and the number of ASH neurons containing aggregates increased as animals aged. ASH neuronal cell death required ced-3 caspase function, indicating that the observed cell death is apoptotic. Of interest, ced-3 played a critical role in Htn-Q150-mediated neurodegeneration but not in OSM10::GFP-mediated ASH neurodegeneration. ced-3 function was important but not essential for the formation of protein aggregates. Finally, behavioral assays indicated that ASH neurons, coexpressing Htn-Q150 and OSM10::GFP, were functionally impaired at 3 days before the detection of neurodegeneration, cell death, and protein aggregates.
Berberine Protects against Neuronal Damage via Suppression of Glia-Mediated Inflammation in Traumatic Brain Injury (2014)

Traumatic brain injury (TBI) triggers a series of neuroinflammatory processes that contribute to evolution of neuronal injury. The present study investigated the neuroprotective effects and anti-inflammatory actions of berberine, an isoquinoline alkaloid, in both in vitro and in vivo TBI models. Mice subjected to controlled cortical impact injury were injected with berberine (10 mg·kg(-1)) or vehicle 10 min after injury. In addition to behavioral studies and histology analysis, blood-brain barrier (BBB) permeability and brain water content were determined. Expression of PI3K/Akt and Erk signaling and inflammatory mediators were also analyzed. The protective effect of berberine was also investigated in cultured neurons either subjected to stretch injury or exposed to conditioned media with activated microglia. Berberine significantly attenuated functional deficits and brain damage associated with TBI up to day 28 post-injury. Berberine also reduced neuronal death, apoptosis, BBB permeability, and brain edema at day 1 post-injury. These changes coincided with a marked reduction in leukocyte infiltration, microglial activation, matrix metalloproteinase-9 activity, and expression of inflammatory mediators. Berberine had no effect on Akt or Erk 1/2 phosphorylation. In mixed glial cultures, berberine reduced TLR4/MyD88/NF-κB signaling. Berberine also attenuated neuronal death induced by microglial conditioned media; however, it did not directly protect cultured neurons subjected to stretch injury. Moreover, administration of berberine at 3 h post-injury also reduced TBI-induced neuronal damage, apoptosis and inflammation in vivo. Berberine reduces TBI-induced brain damage by limiting the production of inflammatory mediators by glial cells, rather than by a direct neuroprotective effect.
Microfabricated atomic frequency references (2005)

We describe a design for a microfabricated atomic frequency reference with a volume of several cubic millimetres and a power dissipation in the range of tens of milliwatts. It is anticipated that this frequency reference will be capable of achieving a fractional frequency instability below 10-11 at integration times of hours. 1
Comparison of the sensitivity of culture, PCR and quantitative real-time PCR for the detection of Pseudomonas aeruginosain sputum of cystic fibrosis patients (2009)

In this study, no difference in sensitivity could be found for the detection of P. aeruginosa from sputum between microbiological culture and optimized DNA-extraction and real-time PCR. The results also indicate the importance of the optimization of the DNA-extraction protocol and the PCR format.
Genome search for susceptibility loci of common idiopathic generalised epilepsies (2000)

Genetic factors play a major role in the aetiology of idiopathic generalised epilepsies (IGEs). The present genome scan was designed to identify susceptibility loci that predispose to a spectrum of common IGE syndromes. Our collaborative study included 130 IGE-multiplex families ascertained through a proband with either an idiopathic absence epilepsy or juvenile myoclonic epilepsy, and one or more siblings affected by an IGE trait. In total, 413 microsatellite polymorphisms were genotyped in 617 family members. Non-parametric multipoint linkage analysis, using the GeneHunter program, provided significant evidence for a novel IGE susceptibility locus on chromosome 3q26 (Z(NPL) = 4.19 at D3S3725; P = 0.000017) and suggestive evidence for two IGE loci on chromosome 14q23 (Z(NPL) = 3.28 at D14S63; P = 0.000566), and chromosome 2q36 (Z(NPL) = 2.98 at D2S1371; P = 0.000535). The present linkage findings provide suggestive evidence that at least three genetic factors confer susceptibility to generalised seizures in a broad spectrum of IGE syndromes. The chromosomal segments identified harbour several genes involved in the regulation of neuronal ion influx which are plausible candidates for mutation screening.
Reduction to below Threshold Levels of Glycolate Oxidase Activities in Transgenic Tobacco Enhances Photoinhibition during Irradiation (2000)

The effects of decreased flux in the glycolate pathway on photoinhibition was investigated in transgenic tobacco (Nicotiana tabacum L. cv. SR1) plants. These plants harbored a pumpkin cDNA for glycolate oxidase (GO), an enzyme in the glycolate pathway, under the control of the cauliflower mosaic virus 35S promoter. Some transformants showed both reduced amounts and reduced activities of GO. The decrease of GO was enhanced at a later growth stage of these transformants, whereas no changes were observed in the amounts of other enzymes in the glycolate pathway, such as hydroxypyruvate reductase and serine glyoxylate aminotransferase. The phenotype grown under a low light condition (30 µE s–1 m–2) resembled that of the wild type. Transformants with about 35% lower GO activity than wild type, had a lower Fv/Fm under 500 µE s–1 m–2 irradiation for 8 h. After 60 µE s–1 m–2 irradiation for 8 h, Fv/Fm was lowered in some transformants with less than 20% of the GO activity of the wild type. These results suggest that photosynthesis was susceptible to photoinhibition with reduction to below threshold levels of GO activities and that higher activities of GO are required under a higher irradiation. The increase in the electron transport rate (ETR) with increased irradiation was suppressed only in transformants that had GO activity one-third less than the wild type, suggesting that the regeneration of the substrate for the Calvin cycle was decreased only when there was an extreme reduction of GO. These results also suggest that the photosystem was disturbed when the concentration of the substrate for the Calvin cycle decreased until it became insufficient to receive the excess photon energy generated in each light environment.
A 30-residue-long "export initiation domain" adjacent to the signal sequence is critical for protein translocation across the inner membrane of Escherichia coli. (1991)

Signal sequences serve to target proteins to the secretory pathway in both prokaryotic and eukaryotic cells. However, although necessary, the presence of a signal sequence is not always sufficient to ensure efficient membrane translocation. One feature of the nascent chain that adversely affects secretion, at least in Escherichia coli, is the presence of positively charged amino acids immediately downstream of the signal sequence. We have exploited this sensitivity to positively charged residues to demonstrate the presence of a sharply delimited "export initiation domain" that comprises the signal sequence and its approximately 30 downstream residues. A string of six consecutive lysines completely blocks translocation when placed inside this domain but not when placed only a few residues further away.
Antagonistic Interactions of Kleisins and DNA with Bacterial Condensin MukB (2006)

MukBEF is a bacterial SMC (structural maintenance of chromosome) complex required for faithful chromosome segregation in Escherichia coli. The SMC subunit of the complex, MukB, promotes DNA condensation in vitro and in vivo; however, all three subunits are required for the function of MukBEF. We report here that MukEF disrupts MukB x DNA complex. Preassembled MukBEF was inert in DNA binding or reshaping. Similarly, the association of MukEF with DNA-bound MukB served to displace MukB from DNA. When purified from cells, MukBEF existed as a mixture of MukEF-saturated and unsaturated complexes. The holoenzyme was unstable and could only bind DNA upon dissociation of MukEF. The DNA reshaping properties of unsaturated MukBEF were identical to those of MukB. Furthermore, the unsaturated MukBEF was stable and proficient in DNA binding. These results support the view that kleisins are not directly involved in DNA binding but rather bridge distant DNA-bound MukBs.
Immediate and late results of anal ileostomy after total proctocolectomy for ulcerative colitis (1960)

Summary The various surgical and physiologic problems associated with anal ileostomy after performance of total proctocolectomy are discussed. An opinion is given as to the value of this procedure. It is judged that anal ileostomy can be performed only when “colonization” of the terminal part of the ileum has taken place after performance of abdominal ileostomy. The immediate and late results obtained for five patients thus operated upon are presented.
A simulation efficiency improvement method for simulation-based analog cell synthesis (2003)

This paper presents a new simulation-based analog cell synthesis approach with improved simulation efficiency. For the hierarchical synthesis of analog cell we developed sub-circuit optimizers such as the current mirror and differential input stage. Each sub-circuit optimizer can be used for synthesis of analog cells such as OTA (operational transconductance amplifier), 2-stage op-amp and comparator. To reduce the time spent on the simulation-based synthesis, we propose a two-stage searching scheme and simulation data reuse scheme. With these schemes the synthesis time spent on the OTA was reduced from 301.05 s to 56.52 s, i.e. by 81.1%. Since our synthesis system does not need other additional physical parameters except SPICE parameters, and is independent of the process and its model level, the time spent to port to other process is minimized. We synthesized an OTA and 2-stage op-amp respectively with our approach to show its usefulness.
Hybrid ARQ with selective combining for video transmission over wireless channels (2002)

We investigate hybrid ARQ schemes for low-bit-rate video transmission over wireless channels. We propose and analyze a hybrid ARQ with a selective combining scheme using rate-compatible punctured convolutional (RCPC) codes on Rayleigh fading channels. It is shown that our scheme performs better than the generalized type-II ARQ for bursty error channels. Simulations of a real-time video TDMA transmission system are also performed. A better video quality can be obtained by our proposed scheme with a bounded delay. Analytical results of the throughput and packet error rate are compared to the simulation results. Our analysis based on a finite-state Markov channel model is shown to give very good agreement with simulations.
PERANCANGAN DAN IMPLEMENTASI ANIMATED STICKER SEBAGAI MEDIA EDUKASI MENGENAI COVID-19 DENGAN MENGGUNAKAN METODE MDLC (2021)

Seluruh dunia sedang digemparkan dengan adanya pandemi COVID-19, virus corona yang dikategorikan baru ini membuat panik dan resah masyarakat tidak terkecuali di Indonesia. Kasus yang terkonfirmasi positif covid-19 terus mengalami peningkatan. Sehingga menjalankan protokol kesehatan menjadi hal terpenting yang harus dilakukan. Berbagai cara pencegahan dan penanganan dilakukan untuk menekan penyebaran virus ini, salah satunya yaitu dengan media edukasi dan informasi kepada masyarakat tentang berbagai cara yang bisa dilakukan untuk mencegah penularan virus corona. Studi literatur ini memberikan tahapan mulai dari perancangan hingga implementasi animated stiker sebagai media edukasi mengenai covid-19. Hasil studi literatur ini adalah terbentuknya animated stiker yang dapat digunakan untuk media edukasi dan penyampaian informasi berbagai tindakan â€“ tindakan pencegahan yang dapat dilakukan masyarakat sebagai pemutusan rantai penyebaran virus corona. Dengan menggunakan media visual yang informatif dan menarik, tentunya dapat membuat masyarakat membaca dengan seksama dan memudahkan proses pemahaman masyarakat. Dengan demikian dapat disimpulkan bahwa penggunaan media visual animated stiker dengan metode MDLC dapat mempermudah masyarakat dalam penerimaan informasi yang lebih jelas dan mudah dipahami.
Automated Machine Learning (2020)

This open access book presents the first comprehensive overview of general methods in Automated Machine Learning (AutoML), collects descriptions of existing systems based on these methods, and discusses the first series of international challenges of AutoML systems. The recent success of commercial ML applications and the rapid growth of the field has created a high demand for off-the-shelf ML methods that can be used easily and without expert knowledge. However, many of the recent machine learning successes crucially rely on human experts, who manually select appropriate ML architectures (deep learning architectures or more traditional ML workflows) and their hyperparameters. To overcome this problem, the field of AutoML targets a progressive automation of machine learning, based on principles from optimization and machine learning itself. This book serves as a point of entry into this quickly-developing field for researchers and advanced students alike, as well as providing a reference for practitioners aiming to use AutoML in their work.
Network Forensics Analysis with Evidence Graphs. (2005)

We develop a prototype network forensics analysis tool that integrates presentation, manipulation and automated reasoning of intrusion evidence. We propose the evidence graph as a novel graph model to facilitate the presentation and manipulation of intrusion evidence. For automated evidence analysis, we develop a hierarchical reasoning framework that includes local reasoning and global reasoning. In local reasoning, we apply Rule-based Fuzzy Cognitive Maps (RBFCM) to model the state evolution of suspicious hosts. In global reasoning, we aim to identify group of strongly correlated hosts in the attack and derive their relationships in the attack scenario. Our analysis mechanism effectively integrates analyst feedbacks into the automated reasoning process. Experimental results demonstrate the potential of our proposed techniques.
Magnetic properties and structure of a new multilayer [FeTaN/TaN]<i>n</i> for recording heads (1997)

In this article, the structure and soft magnetic properties of [FeTaN/TaN]n multilayers have been studied. Best multilayer films have coercivity of 1.2 Oe, which is further decreased to 0.5 Oe by annealing up to 400 °C. The saturation magnetization is 19.5 kG. The initial permeability of multilayer films is 1200 and is constant up to 100 MHz. A predominant α-Fe(110) texture is observed by x-ray diffraction patterns and Mössbauer spectra (MS), but a small amount of ferromagnetic ε-FexN (x⩾3) and paramagnetic ε-FexN (2&lt;x&lt;3) phases are identified by MS, which may account for the relatively large magnetostriction (∼5×10−6). The temperature dependence of MS and x ray show good thermal stability up to 430 °C.
Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐<i>lpr/lpr</i> mice by heparin (1990)

Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL-lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL-lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low-dose heparin might be useful in preventing renal damage in patients with lupus nephritis.
Reconfigurable MEMS-enabled LC-tank for multi-band CMOS oscillator (2005)

A wide frequency span reconfigurable MEMS-enabled LC-tank network for a multi-band RF oscillator is implemented, made of ohmic RF-MEMS switches, spiral suspended inductors and metal-insulator-metal (MIM) capacitors all integrated on a high resistivity silicon MEMS substrate. The LC-tank is connected to a differential cross-coupled n-MOS pair on a separate CMOS substrate, by chip-on-chip integration and wire bonding, leading to the complete MEMS-CMOS oscillator prototype. The separate LC-tank and the complete oscillator are both tested on-wafer through RF-probing. Measurement results show two resonance frequencies of 1.375 GHz (Q = 7.2) and 3.605 GHz (Q = 14.4) for the MEMS-enabled LC-tank. The MEMS-CMOS oscillator shows a phase noise of -124.5 dBc at 1MHz frequency offset, with 3mA bias current at 1.2 V power supply. Overall oscillator performances well compare with state-of-the-art non-reconfigurable CMOS oscillator designs.