gebhart/patrepeval huggingface dataset:
Novel anti-EPHA2 antibody, DS-8895a for cancer treatment (2016)

Overexpression of EPHA2 has been observed in multiple cancers and reported to be associated with poor prognosis. Here, we produced an afucosylated humanized anti-EPHA2 monoclonal antibody (mAb), DS-8895a for cancer treatment. The antibody recognizes the extracellular juxtamembrane region of EPHA2 and therefore can bind to both full-length and truncated forms of EPHA2, which are anchored to cell membranes and recently reported to be produced by post-translational cleavage in tumors. DS-8895a exhibited markedly increased antibody dependent cellular cytotoxicity (ADCC) in vitro and also inhibited tumor growth in EPHA2-positive human breast cancer MDA-MB-231 and human gastric cancer SNU-16 xenograft mouse models. Moreover, DS-8895a in combination with cisplatin (CDDP) showed better efficacy than each of the monotherapies did in the human gastric cancer model. These results suggest that a novel antibody, DS-8895a has therapeutic potential against EPHA2-expressing tumors.
Development of pulsed blue light technologies for bacterial biofilm disruption (2019)

In recent studies, we showed that pulsed blue light is more potent in suppressing bacterial growth than continuous wave blue light. The potency of pulsed blue light makes it a viable antimicrobial for suppressing bacteria growth in biofilms, where the protective cover of the biofilm makes it is tougher to suppress bacteria. Consequently, we studied the efficacy of pulsed 450 nm light in suppressing the growth of MRSA and <i>P. acnes</i> biofilms. The results showed 100% bacterial suppression in planktonic cultures of MRSA irradiated with 7.6 J/cm<sup>2</sup> three times a day, using 3 mW/cm<sup>2</sup> irradiance, and in <i>P. acnes</i> planktonic cultures irradiated with 5 J/cm<sup>2</sup> thrice daily for 3 days, using 2 mW/cm<sup>2</sup> irradiance. However, a similar 100% suppression was not attained in MRSA or P. acnes biofilms irradiated thrice daily for 3 days at various fluences; but LIVE/DEAD assay showed a degree of bacterial suppression, with more live cells in controls than irradiated biofilms, and more dead cells in irradiated than control biofilms. In addition, while control biofilms had intact biofilm networks, irradiated biofilms had disrupted biofilm. The higher the dose, the more bacterial suppression and biofilm disruption. These findings confirm our previous reports that 100% bacterial suppression is attainable with pulsed blue light, and suggests further modification of the treatment protocol in order to achieve 100% bacterial suppression in biofilms.
Inflammatory processes and Alzheimer’s disease (2004)

The inflammatory hypothesis of Alzheimer's disease, which states that anti-inflammatory drugs could have beneficial effects on the pathophysiology of Alzheimer's disease, has been extensively investigated in clinical, epidemiological and basic research studies over the last 20 years. However, despite much hope, the hypothesis remains unproven. Although the results from the first small clinical trial with an anti-inflammatory agent in Alzheimer's disease appeared promising, subsequent trials with a variety of anti-inflammatory agents have failed to show beneficial effects. There are many potential reasons for this including drug selection, drug dose, timing and duration of treatment. This article reviews evidence in support of the inflammatory hypothesis in Alzheimer's disease, as well as the progress of clinical trials using specific anti-inflammatory treatment regimens. It is concluded that such treatments should not be recommended, although additional investigation is warranted.
The dimerization of half-molecule fragments of transferrin (1988)

Partial proteolysis was used to prepare half-molecule fragments of hen ovotransferrin. N-Terminal and C-terminal fragments associate to form an N-terminal fragment-C-terminal fragment dimer. Variant forms of the N- and C-terminal fragments can be prepared in which a few amino acid residues are lacking from the C-terminal ends of the fragments. These variant fragments are partially or completely unable to associate; the suggestion that the molecular recognition sites are located in these C-terminal stretches of the N-terminal half-molecule (320-332) and of the C-terminal half-molecule (683-686) is in agreement with X-ray-crystallography data for human lactotransferrin [Anderson, Baker, Dodson, Norris, Rumball, Waters & Baker (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 1769-1773].
Step modeling and safe path planning for a lower limb exoskeleton (2019)

The walking experience in environments with obstacles is a challenge for patients with lower limb pathology. A transparent exoskeleton is an interesting solution since it guarantees the performance of autonomous motion. In this paper, we present a new method to detect and model steps using point cloud data to find a feasible path for the exoskeleton to perform. We use a RGB-D sensor to obtain depth information and perform a scene segmentation strategy. Next, we classify the different detected elements either as a floor, step or obstacle and then use a path planning method to find a collision-free path. Experiments show that the system accomplished satisfactory results for the presented scenarios.
Design Optimization of Mixed-flow Pump Impellers and Diffusers in a Fixed Meridional Shape (2010)

In this paper, design optimization for mixed‐flow pump impellers and diffusers has been studied by using a commercial CFD code and DOE(design of experiments). We also discussed how to improve the performance of the mixed‐flow pump by designing the impeller and diffuser in the mixed‐flow pump. Geometric design variables were defined by the vane plane development which indicates the blade‐angle distributions and length of the impeller and the diffusers. The vane plane development was controlled by using blade‐angle in a fixed meridional shape. First the design optimization of the defined impeller geometric variables was done, and then the flow characteristics were analyzed in the point of incidence angle at the diffuser leading edge for the optimized impeller. Then design optimizations of the defined diffuser shape variables were performed. The importance of the geometric design variables was analyzed by using 2k factorial designs, and the design optimization of the geometric variables were determined using the response surface method. The objective functions are defined as the total head and the total efficiency at the design flow‐rate. From the comparison of CFD results between optimized pump and base design model, the reason for the performance improvement was discussed.
Fast Template Matching Based on Normalized Cross Correlation With Adaptive Multilevel Winner Update (2008)

In this paper, we propose a fast pattern matching algorithm based on the normalized cross correlation (NCC) criterion by combining adaptive multilevel partition with the winner update scheme to achieve very efficient search. This winner update scheme is applied in conjunction with an upper bound for the cross correlation derived from Cauchy-Schwarz inequality. To apply the winner update scheme in an efficient way, we partition the summation of cross correlation into different levels with the partition order determined by the gradient energies of the partitioned regions in the template. Thus, this winner update scheme in conjunction with the upper bound for NCC can be employed to skip unnecessary calculation. Experimental results show the proposed algorithm is very efficient for image matching under different lighting conditions.
Studies on pyrrolidinones. Synthesis of <i>N</i>‐acylpyroglutamic esters with bactericide and fungicide properties (1988)

Abstract The best method to prepare N ‐acylpyroglutamic esters is to react N ‐trimethylsilylpyroglutamic esters with acid chlorides or diketene. These acylesters possess bactericide and fungicide properties against several microorganisms.
The NIDDK Liver Transplantation Database (1997)

The NIDDK Liver Transplantation Database was established to prospectively investigate questions related to the experience of patients evaluated for and undergoing liver transplantation. This article presents the study design, methods, and quality of data collection, along with some of the overall results. Methods: An initial 4-year planning phase was used to develop data collection instruments and quality control procedures regarding assessment for transplantation, liver donors, and the recipients' pre-, peri- and postoperative course. During the 1990-1995 implementation phase, three clinical centers refined the data collection instruments and enrolled and followed consecutive liver transplant candidates who consented to be included in the protocol. Results: The Database contains more than 49,000 data forms from 1563 candidates, 1002 donors, and 916 transplant recipients followed up to 5 years after transplantation. Overall, 95% of protocol forms were completed. The Database includes uniformly defined histology results of liver biopsies performed per protocol and for complications throughout follow-up. In addition, the Database maintains an inventory of available sera for the Serum Bank. All test results of studies performed on the sera are added to the Database. Of 1563 evaluated patients, 59% were deemed eligible for liver transplantation. Of the others who were too well or had contraindications, 15% became eligible later. Characteristics of patients in this study were generally comparable to those of patients nationally. Conclusions: The NIDDK Liver Transplantation Database has yielded comprehensive and high quality data and is a rich resource for extensive analysis about many important clinical aspects of liver transplantation.
??-Adrenoreceptor Antagonists Attenuate Brain Injury After Transient Focal Ischemia in Rats (2006)

Beta-adrenoreceptor antagonists experimentally reduce cardiac and renal injury after ischemia and are also clinically useful for myocardial infarction and severe burns. In addition, beta-adrenoreceptor antagonists provide neuroprotective effects after focal cerebral ischemia in experimental settings. We conducted the present study to compare the neuroprotective effects of several beta-adrenoreceptor antagonists in rat transient focal cerebral ischemia. Halothane-anesthetized normothermic adult male Sprague-Dawley rats were subjected to 2 h of middle cerebral artery occlusion using the intraluminal suture technique confirmed by laser Doppler flowmetry. Rats received an IV infusion of saline 0.5 mL/h, propranolol 100 microg x kg(-1) x min(-1), carvedilol 4 microg x kg(-1) x min(-1), esmolol 200 microg x kg(-1) x min(-1), or landiolol 50 microg x kg(-1) x min(-1) (n = 6 in each group). Infusion was initiated 30 min before middle cerebral artery occlusion and continued for 24 h. Additional rats received esmolol 50 microg x kg(-1) x min(-1) or landiolol 10 microg x kg(-1) x min(-1) intrathecally (IT) via the cisterna magna (n = 5 in each group), according to the same experimental protocol. The neurological deficit score was evaluated at 22 h after reperfusion, and the brains were removed and stained with triphenyltetrazolium chloride for evaluation of infarct volume. Additional rats that received saline, esmolol, and landiolol IV (n = 6 in each group) were allowed to survive for 7 days followed by measurement of infarct size. Neurological deficit scores were smaller in rats treated with propranolol-IV, carvedilol-IV, esmolol-IV, landiolol-IV, esmolol-IT, and landiolol-IT compared with saline-treated rats (P < 0.05). Cortical and striatum infarct volumes were less in the rats receiving beta-adrenoreceptor antagonists via either IV or IT than in saline-treated rats (P < 0.05). We conclude that beta-adrenoreceptor antagonists improve neurological and histological outcomes after transient focal cerebral ischemia in rats independent of administration route.
Synthesis of [S‐[1‐14C]Val7]VALSPODAR application of (+)/(−)‐[13,14Cn]BABS and (+)/(−)‐[13,14Cn]DPMGBS, part 4 (2000)

VALSPODAR 2, a cyclic undecapeptide anticancer drug derived from natural Cyclosporin D 10, was labelled with Carbon-14 in a nine step synthesis. The sequence started from (−)-[1-14C]BABS 1a, a highly versatile two-carbon synthon for a broad spectrum of singly/multiply labelled substance classes, which after conversion to (−)-[1-14C]DPMGBS 1b and subsequent alkylation with isopropyl iodide gave e.p. N-Boc-S[1-14C]valine 7 in 46% yield. Coupling to the respective linear decapeptide P8→6D, followed by cyclization and selective oxidation afforded the labelled drug substance in an overall radiochemical yield of 9%. Copyright © 2000 John Wiley & Sons, Ltd.
A Multirange Vehicle Speed Prediction With Application to Model Predictive Control-Based Integrated Power and Thermal Management of Connected Hybrid Electric Vehicles (2021)

Abstract Connectivity and automated driving technologies have opened up new research directions in the energy management of vehicles which exploit look-ahead preview and enhance the situational awareness. Despite this advancement, the vehicle speed preview that can be obtained from vehicle-to-vehicle/infrastructure (V2V/I) communications is often limited to a relatively short time-horizon. The vehicular energy systems, specifically those of the electrified vehicles, consist of multiple interacting power and thermal subsystems that respond over different time-scales. Consequently, their optimal energy management can greatly benefit from long-term speed prediction beyond that available through V2V/I communications. Accurately extending the look-ahead preview, on the other hand, is fundamentally challenging due to the dynamic nature of the traffic environment. To address this challenge, we propose a data-driven multirange vehicle speed prediction strategy for arterial corridors with signalized intersections, providing the vehicle speed preview for three different ranges, i.e., short-, medium-, and long-range. The short-range preview is obtained by V2V/I communications. The medium-range preview is realized using a neural network (NN), while the long-range preview is predicted based on a Bayesian network (BN). The predictions are updated in real-time based on the current state of traffic and incorporated into a multihorizon model predictive control (MH-MPC) for integrated power and thermal management (iPTM) of connected vehicles. The results of design and evaluation of the performance of the proposed data-informed MH-MPC for iPTM of connected hybrid electric vehicles (HEVs) using traffic data for real-world city driving are reported.
A simulation study of hardware-oriented DSM approaches (1996)

Distributed shared memory (DSM) combines the advantages of shared-memory multiprocessors and distributed computer systems. Evaluations of four experimental or commercial approaches to hardware DSM show its potential for large-scale, high-performance multiprocessor systems. Such an analysis helps in developing guidelines and practical recommendations to further improve existing systems. The four approaches are Dash (Directory Architecture for Shared Memory), SCI (Scalable Coherent Interface), DDM (Data Diffusion Machine) and KSR1 (Kendall Square Research-1).
Synthesis of 2,′:5′,2″-terpyridine and 2,2′:5′,2″:5″,2‴-quaterpyridine and their photocatalysis of the reduction of water (1996)

2,2′:5′,2″-Terpyridine (OPy-3) and 2,2′:5′,2″:5″,2‴-quaterpyridine (OPy-4) are prepared by Ni°complex-catalysed polycondensation of 2,5-dichloropyridine in the presence of an excess of 2chloropyridine. These two compounds show more efficient photocatalysis of H2 evolution by the reduction of water than p-terphenyl and p-quaterphenyl in the presence of triethylamine as an electron donor, and RuCl3 or K2PtCl6 as a source of Ruo or Pto colloids which function as an electron mediator. The primary photochemical processes of OPy-n(n= 3 or 4) and the successive reactions have been investigated by γ-radiolysis, pulse radiolysis and laser flash photolysis. The OPy-n molecules are converted to their anion radicals through reductive quenching of the excited states. A mechanism for the photocatalysis of hydrogen evolution is proposed in which the anion radicals supply electrons to protons on the metal colloids. The anion radicals undergo protonation in competition with electron transfer, resulting in the loss of photocatalytic activity.
Precision Thermostat for High Temperatures (1950)

A precision thermostat has been developed, based upon that of Roberts, for the control of high temperatures (1000°—1550°C). With the instrument described, temperatures are readily maintained constant within ±0.1°C for several hours, and within ±1.0°C for several days. In this method of control a thyratron is used in conjunction with an a.c. bridge and high gain amplifier. The phase angle of the unbalanced bridge regulates the firing of the thyratron. The control is highly sensitive and independent of normal fluctuations in line voltage. The thermostat is convenient to operate, easy to adjust for any temperature, and reliable for periods of continuous operation from a few minutes to several days.
Perioperative Antibiotic Usage by Facial Plastic Surgeons (2006)

Surgical site infection in facial plastic surgery can be reduced by better conformance to currently available evidence-based guidelines. We offer specific recommendations that are supported by the current literature.
Deep level defects in electron-irradiated 4H SiC epitaxial layers (1997)

Deep level defects in electron-irradiated 4H SiC epitaxial layers grown by chemical vapor deposition were studied using deep level transient spectroscopy. The measurements performed on electron-irradiated p+n junctions in the temperature range 100–750 K revealed several electron traps and one hole trap with thermal ionization energies ranging from 0.35 to 1.65 eV. Most of these defects were already observed at a dose of irradiation as low as ≈5×1013 cm−2. Dose dependence and annealing behavior of the defects were investigated. For two of these electron traps, the electron capture cross section was measured. From the temperature dependence studies, the capture cross section of these two defects are shown to be temperature independent.
Development of Amperometric and Microgravimetric Immunosensors and Reversible Immunosensors Using Antigen and Photoisomerizable Antigen Monolayer Electrodes (1997)

Antigen monolayers assembled onto Au-electrodes or Au-electrodes associated with quartz crystals act as active interfaces for the amperometric or microgravimetric analysis of the complementary antibody and provide the grounds for the development of electrochemical and piezoelectric immunosensors. The antigen monolayer of Nε-2,4-dinitrophenyl-l-lysine is assembled on an electrode. The anti-dinitrophenyl antibody, anti-DNP-Ab, is sensed by the antigen monolayer, and the formation of the antigen−antibody complex at the monolayer interface is probed by the insulation of the electrode toward a redox probe in the electrolyte solution. The formation of the antibody−antigen complex is amplified by the application of the anti-antibody or the use of a ferrocene-functionalized redox-enzyme, glucose oxidase, as redox probe. A 3,5-dinitrosalicylic acid antigen monolayer bound to Au-electrodes associated with a quartz crystal is used as active interface for the microgravimetric, quartz-crystal-microbalance analysis of the anti-DNP-Ab. Photoisomerizable antigen monolayer electrodes provide the basis for tailoring reversible immunosensors. The dinitrospiropyran monolayer, SP-state, is assembled on Au-electrodes or quartz crystals. The monolayer exhibits reversible photoisomerizable features, and irradiation of the SP-monolayer, 360 < λ < 380 nm, yields the protonated merocyanine monolayer, MRH+-state. Further irradiation of the MRH+-monolayer electrode, λ > 495 nm, restores the SP-monolayer electrode. The SP-monolayer acts as antigen for anti-DNP-Ab, whereas the MRH+-monolayer lacks antigen properties for anti-DNP-Ab. This enables the amperometric or piezoelectric transduction of the formation of the antigen−anti-DNP-Ab complex at the SP-monolayer interface. By photoisomerization of the monolayer to the MRH+-state, the Ab is washed-off from the sensing interface. Subsequent light-induced isomerization of the monolayer to the SP-state regenerates the electrochemically or piezoelectrically active sensing interfaces.
Identifying Process Variables for a Low Atmospheric Pressure Stunning-Killing System (2007)

Current systems for preslaughter gas stunning and killing of broilers use process gases such as CO2, N2, Ar, or a mixture of these gases with air or O2. These systems, known as controlled-atmosphere stunning-killing systems, work by displacing O2, ultimately to induce hypoxia in the bird, leading to unconsciousness and death. In this study, mechanical removal of O2 by rapidly reducing air pressure was investigated as an alternative to controlled-atmosphere stunning-killing systems. Low atmospheric pressure systems could offer advantages in worker safety and operational gas cost because they operate solely with atmospheric air. This study comprised 2 experiments, one to define the initial range of effective pressures, and the second to determine a recommended process pressure. In experiment 1, 48 female broilers, aged 63 d, were subjected to 6 different pressure treatments, ranging from 70.9 to 17.8 kPa. In experiment 2, 56 male broilers, aged 60 d, were subjected to 7 different pressure treatments, ranging from 35.3 to 17.8 kPa. Birds were individually placed in an airtight vessel and exposed to a pressure treatment for 2 min after the final pressure was attained. Results from experiment 1 showed that the effective range of pressure was between 29.5 and 17.8 kPa, with only 25% of the birds exposed to 29.5 kPa surviving and none of the birds exposed to 17.8 kPa surviving. Experiment 2 used a finer resolution of pressure increments, and the estimated pressure level lethal for 99.99% of the birds was determined to be 19.4 kPa.
Cytologic Features of Primary Adenoid Cystic Carcinoma of the Uterine Cervix (1996)

Although the endocervical brush technique may yield well-preserved cells and tissue fragments morphologically characteristic of adenoid cystic carcinoma of the cervix, confusion with more common tumors, such as endometrial adenocarcinoma, still may create cytologic diagnostic difficulties.
Pro jQuery Mobile (2011)

You need to build an app, and you need it to run everywhere. And you need it now! jQuery Mobile gives you the ability to write once and run everywhere using jQuery and jQuery UI. Pro jQuery Mobile wil