gebhart/patrepeval huggingface dataset:
Fatty acyl chain order in lecithin model membranes determined from proton magnetic resonance (1978)

Proton magnetic resonance (1H NMR) has been used to compare the local orientational order of acyl chains in phospholipid bilayers of multilamellar and small sonicated vesicular membranes of dipalmitoyllecithin (DPL) at 50 degrees C and egg yolk lecithin (EYL) at 31 degrees C. The orientational order of the multilamellar systems was characterized using deuterium magnetic resonance order parameters and 1H NMR second moments. 1H NMR line shapes in the vesicle samples were calculated using vesicle size distributions, determined directly using electron microscopy, and a theory of motional narrowing, which takes into account the symmetry properties of the bilayer systems. The predicted non-Lorentzian line shapes and widths were found to be in good agreement with experimental results, indicating that the local orientational order (called "packing" by many workers) in the bilayers of small vesicles and in multilamellar membranes is substantially the same. This results was found to be true not only for the largest 1H NMR line associated with the nonterminal methylene protons but also for the resolved 1H NMR lines due to the alpha-CH2 and the terminal CH3 positions on the acyl chain. Analysis of the vesicle 1H NMR spectra of EYL taken with different medium viscosities yielded a value of approximately 4 X 10(-8) cm2 s-1 for the lateral diffusion constant of the phospholipid molecules at 31 degrees C.
Nuclear localization signal binding protein from <i>Arabidopsis</i> mediates nuclear import of <i>Agrobacterium</i> VirD2 protein (1997)

T-DNA nuclear import is a central event in genetic transformation of plant cells by Agrobacterium. Presumably, the T-DNA transport intermediate is a single-stranded DNA molecule associated with two bacterial proteins, VirD2 and VirE2, which most likely mediate the transport process. While VirE2 cooperatively coats the transported single-stranded DNA, VirD2 is covalently attached to its 5' end. To better understand the mechanism of VirD2 action, a cellular receptor for VirD2 was identified and its encoding gene cloned from Arabidopsis. The identified protein, designated AtKAPalpha, specifically bound VirD2 in vivo and in vitro. VirD2-AtKAPalpha interaction was absolutely dependent on the carboxyl-terminal bipartite nuclear localization signal sequence of VirD2. The deduced amino acid sequence of AtKAPalpha was homologous to yeast and animal nuclear localization signal-binding proteins belonging to the karyopherin alpha family. Indeed, AtKAPalpha efficiently rescued a yeast mutant defective for nuclear import. Furthermore, AtKAPalpha specifically mediated transport of VirD2 into the nuclei of permeabilized yeast cells.
Thermodynamic studies of the a ? phase transformation in zirconium using a subsecond pulse heating technique (1975)

Measurements of the temperature and energy of the <i>α</i> → <i>β</i> phase transformation, and the electrical resistivity near and at the transformation point of zirconium using a subsecond duration pulse heating technique are described. The results yield 1147 K for the transformation temperature and 3980 J · mol<sup>-1</sup> for the transformation energy. Electrical resistivity is found to decrease by 17 percent during the transformation. Estimated inaccuracies of the measured properties are: 10 K for the transformation temperature, 5 percent for the transformation energy, and 2 percent for the electrical resistivity.
Nasal spray bromocriptine: Effects on serum prolactin in puerperal women (1996)

Nasal route seems to be an effective and probably safe administration route for bromocriptine.
Corrigendum: Extreme expansion of the olfactory receptor gene repertoire in African elephants and evolutionary dynamics of orthologous gene groups in 13 placental mammals. (2015)

Olfactory receptors (ORs) detect odors in the environment, and OR genes constitute the largest multigene family in mammals. Numbers of OR genes vary greatly among species--reflecting the respective species' lifestyles--and this variation is caused by frequent gene gains and losses during evolution. However, whether the extent of gene gains/losses varies among individual gene lineages and what might generate such variation is unknown. To answer these questions, we used a newly developed phylogeny-based method to classify >10,000 intact OR genes from 13 placental mammal species into 781 orthologous gene groups (OGGs); we then compared the OGGs. Interestingly, African elephants had a surprisingly large repertoire (∼ 2000) of functional OR genes encoded in enlarged gene clusters. Additionally, OR gene lineages that experienced more gene duplication had weaker purifying selection, and Class II OR genes have evolved more dynamically than those in Class I. Some OGGs were highly expanded in a lineage-specific manner, while only three OGGs showed complete one-to-one orthology among the 13 species without any gene gains/losses. These three OGGs also exhibited highly conserved amino acid sequences; therefore, ORs in these OGGs may have physiologically important functions common to every placental mammal. This study provides a basis for inferring OR functions from evolutionary trajectory.
False-Positive Colorimetric Capnometry After Ingestion of Carbonated Beverages (2009)

Under proper circumstances, a significant potential exists for false-positive colorimetric capnometric results in the presence of even small amounts of carbonated beverages.
Latent evolutionary potentials under the neutral mutational drift of an enzyme (2007)

Biological systems exhibit mutational robustness, or neutrality, whereby the impact of mutations is minimized. Does neutrality hamper their ability to adapt in the face of changing environments? We monitored changes in genotype and phenotype that occur within a neutral mutational network of an enzyme, experimentally and computationally (see accompanying article). Using the enzyme PON1 as a model, we performed random mutagenesis and purifying selection to purge deleterious mutations. We characterized approximately 300 variants that are apparently neutral, or close to neutral, with respect to PON1's levels of expression and native lactonase activity. Their activities with promiscuous substrates and ligands indicated significant changes in adaptive potentials. Almost half of the variants exhibited changes in promiscuous activities, specificities, or inhibition, and several of these were found to be one or two mutations, closer to potentially new phenotypes: aryl esterase, thiolactonase, phosphotriesterase, or drug resistance. This empirical measure of phenotypic changes under neutrality supports the notion that sequence changes that are neutral, i.e., non-adaptive, in a current context can facilitate adaptation under changing circumstances, by both expanding the activity range of existing enzymes and thus providing an immediate advantage, and by reducing the number of mutations required for divergence of new functions.
Annelid - a Novel Design for Actuated Robots Inspired by Ringed Worm's Locomotion. (2011)

This paper describes the development of a simulation software that advances the idea of a robotic device inspired by ringed worm’s locomotion. Its basic design is made up of an elongated body that is composed of a spring-style skeleton which is coated by a flexible skin. Our principle approach is to choose a shape memory alloy material for the skeleton, resulting in different spring forces exerted by the body under varying temperatures. The overall approach requires the elastic skin to prestress the whole body in its rest position, so that it can spatially extend when thermal energy is induced to the system, and relax when an inbuilt air cooling mechanism dissipates the heat.
Phosphodiesterase 11A Expression in the Adrenal Cortex, Primary Pigmented Nodular Adrenocortical Disease, and other Corticotropin-independent Lesions (2008)

A variety of adrenal tumors and bilateral adrenocortical hyperplasias (BAH) leading to Cushing syndrome (CS) may be caused by aberrant cAMP signaling. We recently identified patients with a micronodular form of BAH that we have called "isolated micronodular adrenocortical disease" (iMAD) in whom CS was associated with inactivating mutations in phosphodiesterase (PDE) 11A ( PDE11A). In the present study, we examined PDE11A expression in normal adrenocortical tissue, sporadic tumors, and hyperplasias without PDE11A mutations, and primary pigmented nodular adrenocortical disease (PPNAD) and adenomas from patients with PRKAR1A and a single tumor with a GNAS mutation. The total number of the tumor samples that we studied was 22. Normal human tissues showed consistent PDE11A expression. There was variable expression of PDE11A in sporadic adrenocortical hyperplasia or adenomas; PPNAD tissues from patients with PRKAR1A mutations expressed consistently high levels of PDE11A in contrast to adenomas caused by GNAS mutations. Phosphorylated CREB was the highest in tissues from patients with iMAD compared to all other forms of BAH and normal adrenal tissue. We conclude that PDE11A is expressed widely in adrenal cortex. Its expression appears to be increased in PPNAD but varies widely among other adrenocortical tumors. PRKAR1A expression appears to be higher in tissues with PDE11A defects. Finally, sequencing defects in PDE11A are associated with a high state of CREB phosphorylation, just like PRKAR1A mutations. These preliminary data suggest that these two molecules are perhaps regulated in a reverse manner in their control of cAMP signaling in adrenocortical tissues.
A systolic array for computing B A&lt;sup&gt;-1&lt;/sup&gt; (1987)

This paper is devoted to the design of a new systolic array of n (n + 1) elementary processors which computes B A <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> within 4n + p - 2 time steps, where A is a dense (nonsingular) n by n matrix, B is a dense p by n matrix. The array can be directly extended to compute the vector Y = B A <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> R, where R is a vector with n components. Such computations arise frequently in signal processing applications.
Schema Conversion Methods between XML and Relational Models. (2003)

In this chapter, three semantics-based schema conversion methods are presented: 1) CPI converts an XML schema to a relational schema while preserving semantic constraints of the original XML schema, 2) NeT derives a nested structured XML schema from a flat relational schema by repeatedly applying the nest operator so that the resulting XML schema becomes hierarchical, and 3) CoT takes a relational schema as input, where multiple tables are interconnected through inclusion dependencies and generates an equivalent XML schema as output.
Viability and histological changes of encapsulated rat hepatocyte after transplantation (2001)

Objective To study the viability and histological change of encapsulated rat hepatocytes after being transplanted into abdominal cavity of rat. Methods The two-step collagenase perfusing method was used to separate hepatocytes from Wistar rat liver. The separated hepatocytes were purified with Percoll density gradient centrifugation and encapsulated by the alginate-barium method. Then the purified hepatocytes were transplanted into abdominal cavity of SD rats (group 1) and the encapsulated hepatocytes were transplanted into abdominal cavity of SD rats (group 2) and Wistar rats (group 3). At different time points post-transplantation, trypan blue stain exclusion was used to determine the viability of recovered hepatocytes. The histological changes of transplanted microencapsulated hepatocytes was examined using HE stain. Results Twenty-four h after transplantation, the viability of hepatocytes between group 1 and group 2 showed significant difference (P 0.05). At day 4 and day 7 after transplantation, the viability of hepatocytes showed significant difference between group 1 and group 2, and group 2 and group 3 (P 0.05). From day 4 post-transplantation, fibrosis overgrowth was found around some microencapsules, and it was more obvious in group 2 than in group 3. Conclusions Microencapsulation can provide protection to transplanted hepatocytes from host immunorejection, and thus increase the viability of hepatocytes post transplantation. The existence of inadequately encapsulated microencapsule cause the fibrosis overgrowth around these capsules, resulting in ischemia and subsequent necrosis of the hepatocytes and decreasing hepatocyte viability.
Dealing with heterogeneous data in pub/sub systems: the concept-based approach (2004)

The event-based approach is well suited for integrating autonomous components or applications into complex systems by means of exchanging events. Event-based systems need an event dissemination mechanism (or notification service) to deliver relevant events to interested consumers. The publish/subscribe interaction paradigm has been gaining relevance for this purpose. One of the main characteristics of publish/subscribe systems is that they decouple producers and consumers so that they are unknown to each other. Therefore, the consideration of data heterogeneity issues is fundamental. However, most pub/sub notification services do not support the interaction among heterogeneous event producers and consumers. In this paper, we describe the concept-based approach as a high-level dissemination mechanism for distributed and heterogeneous event-based applications. It enhances the notification service by enabling it to pass semantic information across through component, institutional or cultural boundaries. It provides a high level abstraction for a meaningful exchange of data within the pub/sub interaction paradigm.
Designing a Dynamic Ramp With an Invariant Inductor in Current-Mode Control for an On-Chip Buck Converter (2013)

Designing a dynamic ramp with an invariant inductor in current-mode control for an on-chip Buck converter is proposed in this paper. This configuration maintains system stability under different input/output voltages without changing the inductor and compensation circuit. The dynamic ramp can be adjusted according to the variation in the output voltage or the voltage droop between the input voltage and the output voltage to maintain bandwidth and phase margin using the invariant inductor and compensation circuit. Finally, 14-V input voltage, 12-V output voltage, and 24-W output power with the dynamic ramp sampling the output voltage is implemented using MathCAD predictions, SIMPLIS simulation results, and experimental results to verify its viability and superiority.
A Survey of Emerging Biometric Technologies (2010)

Computer Security System / technology have passed through several changes. The trends have been from what you know (e.g. password, PIN, etc) to what you have (ATM card, Driving License, etc) and presently to who you are (Biometry) or combinations of two or more of the trios. This technology (biometry) has come to solve the problems identified with knowledge-based and token-based authentication systems. It is possible to forget your password and what you have can as well be stolen. The security of determining who you are is referred to as BIOMETRIC. Biometric, in a nutshell, is the use of your body as password. This paper explores the various methods of biometric identification that have evolved over the years and the features used for each modality.
Microbial Metabolism of Artemisinin by <i>Mucor </i><i>p</i><i>olymorphosporus</i> and <i>Aspergillus </i><i>n</i><i>iger</i> (2002)

Artemisinin (1) was transformed by Mucor polymorphosporus and Aspergillus niger. Five products were identified as 9β-hydroxyartemisinin (2), 3β-hydroxyartemisinin (3), deoxyartemisinin (4), 3β-hydroxydeoxyartemisinin (5), and 1α-hydroxydeoxyartemisinin (6). Products 2, 3, and 6 are new compounds.
A Parking-state-based Transition Matrix of Traffic on Urban Networks (2015)

Abstract The urban parking and the urban traffic systems are essential components of the overall urban transportation structure. The short- term interactions between these two systems can be highly significant and influential to their individual performance. The urban parking system, for example, can affect the searching-for-parking traffic, influencing not only overall travel speeds in the network (traffic performance), but also total driven distance (environmental conditions). In turn, the traffic performance can also affect the time drivers spend searching for parking, and ultimately, parking usage. In this study, we propose a methodology to model macroscopically such interactions and evaluate their effects on urban congestion. The model is built on a transition matrix describing how, over time, vehicles in an urban area transition from one parking-related state to another. With this model it is possible to estimate, based on the traffic and parking demand as well as the parking supply, the amount of vehicles searching for parking, the amount of vehicles driving on the network but not searching for parking, and the amount of vehicles parked at any given time. More importantly, it is also possible to estimate the total (or average) time spent and distance driven within each of these states. Based on that, the model can be used to design and evaluate different parking policies, to improve (or optimize) the performance of both systems. A simple numerical example is provided to show possible applications of this type. Parking policies such as increasing parking supply or shortening the maximum parking duration allowed (i.e., time controls) are tested, and their effects on traffic are estimated. The preliminary results show that time control policies can alleviate the parking-caused traffic issues without the need for providing additional parking facilities. Results also show that parking policies that intend to reduce traffic delay may, at the same time, increase the driven distance and cause negative externalities. Hence, caution must be exercised and multiple traffic metrics should be evaluated before selecting these policies. Overall, this paper shows how a parking-state-based transition matrix, despite its simplicity, can be used to efficiently evaluate the urban traffic and parking systems macroscopically. The proposed model can be used to estimate both, how parking availability can affect traffic performance (e.g., average time searching for parking, number of cars searching for parking); and how different traffic conditions (e.g., travel speed, density in the system) can affect drivers ability to find parking. Moreover, the proposed model can be used to study multiple strategies or scenarios for traffic operations and control, transportation planning, land use planning, or parking management and operations.
<scp>l</scp> -Arginine Induces Nitric Oxide–Dependent Vasodilation in Patients With Critical Limb Ischemia (1996)

We conclude that intravenous L-arginine induces NO-dependent peripheral vasodilation in patients with critical limb ischemia. These effects are paralleled by increased urinary NO3- and cGMP excretion, indicating an enhanced systemic NO production. Increased urinary NO3- excretion may be a sum effect of NO synthase substrate provision (L-arginine) and increased shear stress (PGE1 and L-arginine).
The availability of a home tonometer as a factor that increases therapy compliance in outpatients with arterial hypertension (2012)

The use of technical means, home automatic tonometers in particular, is one of the possible ways of enhancing therapy compliance. Aim: to evaluate the impact of the availability of an automatic tonometer on patient adherence to antihypertensive therapy and its efficiency. Subjects and methods. The investigation included 60 patients aged 45–75 years with grades 1–2 arterial hypertension. The patients were randomized to tonometer Group «OMRON» that was given an OMRON automatic tonometer and control Group that was not given the latter. Compliance-increasing methods, such as giving losartan free of charge, a self-control diary, and written recommendations, were used in all the study participants. General clinical examination, office blood pressure (BP) measurement, biochemical blood testing, and questioning using the hospital anxiety and depression scale (HADS), Morisky-Green test, and a visual analogue scale (VAS) were employed to assess quality of life. Results. Both groups achieved a reduction in systolic and diastolic blood pressures (SBP and DBP). The quality of life was improved only in Group «OMRON» (VAS scores increased from 64,8 to 73,6; p=0,01). At visit 1 (at week 3), the patients in both groups showed an equally high level of compliance. At visit 2 (at week 12) the compliance in Group «OMRON» increased up to 96,4% whereas that in Group «Control» decreased to 81,3% (a 15,1% difference; p
Gonadotropin Promotion of Adventitious Root Production on Cuttings of <i>Begonia semperflorens</i> and <i>Vitis vinifera</i> (1968)

Adventitious rooting of Begonia semperflorens cv. Indian Maid and Vitis vinifera cv. Semillon stem cuttings was significantly promoted by human chorionic gonadotropin (HCG). Basal sections of HCG treated cuttings upon which promoted rooting took place had markedly less endogenous gibberellin (GA) activity than non-treated controls or apical sections of treated ones, while changes in auxin levels were not found. HCG also inhibited GA(3)-induced reducing sugar release from embryoless barley endosperm halves. These findings are discussed in the light of a possible analogy to gonadotropin action in animal systems.
Regulatory Role for a Novel Human Thioredoxin Peroxidase in NF-κB Activation (1997)

Reduction-oxidation (redox) plays a critical role in NF-kappaB activation. Diverse stimuli appear to utilize reactive oxygen species (e.g. hydrogen peroxide) as common effectors for activating NF-kappaB. Antioxidants govern intracellular redox status, and many such molecules can reduce H2O2. However, functionally, it does appear that different antioxidants are variously selective for redox regulation of certain transcription factors such as NF-kappaB. For NF-kappaB, thioredoxin has been described to be a more potent antioxidant than either glutathione or N-acetylcysteine. Thioredoxin peroxidase is the immediate enzyme that links reduction of H2O2 to thioredoxin. Several putative human thioredoxin peroxidases have been identified using recursive sequence searches/alignments with yeast or prokaryotic enzymes. None has been characterized in detail for intracellular function(s). Here, we describe a new human thioredoxin peroxidase, antioxidant enzyme AOE372, identified by virtue of its protein-protein interaction with the product of a proliferation association gene, pag, which is also a thiol-specific antioxidant. In human cells, AOE372 defines a redox pathway that specifically regulates NF-kappaB activity via a modulation of IkappaB-alpha phosphorylation in the cytoplasm. We show that AOE372 activity is regulated through either homo- or heterodimerization with other thiol peroxidases, implicating subunit assortment as a mechanism for regulating antioxidant specificities. AOE372 function suggests thioredoxin peroxidase as an immediate regulator of H2O2-mediated activation of NF-kappaB.
Phase stabilized RF reference signal dissemination over optical fiber employing instantaneous frequency control by VCO (2012)

Stable microwave reference signal transfer systems are required in communication systems, very long baseline interferometer (VLBI) radio astronomy applications, particle accelerators and metrologies. Radio over fiber (RoF) technique is one of candidates which realize precise microwave dissemination without degradation of stability. We developed the precision microwave signal dissemination system in which a fluctuation of phase caused by transmitting optical fiber thermal expansion. This system monitors a phase of the signal reflected at destination, and controls transmitting signal frequency using a voltage controlled oscillator (VCO). The measurement shows that the phase error is 0.098 deg (r.m.s) of the 1.0 GHz microwave signal in 1-km length single mode fiber over 10 hours.