gebhart/patrepeval huggingface dataset:
Can Resveratrol Treatment Control the Progression of Induced Periodontal Disease? A Systematic Review and Meta-Analysis of Preclinical Studies (2019)

Resveratrol is an anti-inflammatory compound found in several foods. Periodontal disease (PD) is associated to other systemic diseases, and inflammation may be responsible for the association. Consequently, controlling inflammation not only may benefit oral health but also may assist with the management of other chronic inflammatory conditions. We aimed to investigate the effects of resveratrol administration on PD control in preclinical studies. A systematic search was performed for scientific articles using both electronic databases and a manual search using combinations of the following keywords: "resveratrol" OR "3,5,4'-trihydroxystilbene" AND "periodontal disease" OR "periodontitis" OR "gingivitis". Only in vivo original studies investigating resveratrol treatment on experimental animal models of PD were selected. A quality assessment of the studies was performed using the Animal Research Reporting In Vivo Experiment (ARRIVE) guidelines, and the risk of bias was assessed using the Syrcle tool. The search returned 570 articles, and 11 matched the inclusion criteria. A meta-analysis showed that resveratrol treatment attenuated alveolar bone loss (τ<sup>2</sup> = 0.0041; 95% CI: -0.14; -0.04). The ARRIVE criteria reported a good quality of studies in general (mean score 28.5 ± 2.5). However, five Syrcle domains indicated a high risk of bias or did not present information clearly. We concluded that, in preclinical studies, resveratrol treatment prevented PD progression.
Newcomer insulin secretory granules as a highly calcium-sensitive pool (2009)

Insulin secretion is biphasic in response to a step in glucose stimulation. Recent experiments suggest that 2 different mechanisms operate during the 2 phases, with transient first-phase secretion due to exocytosis of docked granules but the second sustained phase due largely to newcomer granules. Another line of research has shown that there exist 2 pools of releasable granules with different Ca(2+) sensitivities. An immediately releasable pool (IRP) is located in the vicinity of Ca(2+) channels, whereas a highly Ca(2+)-sensitive pool (HCSP) resides mainly away from Ca(2+) channels. We extend a previous model of exocytosis and insulin release by adding an HCSP and show that the inclusion of this pool naturally leads to insulin secretion mainly from newcomer granules during the second phase of secretion. We show that the model is compatible with data from single cells on the HCSP and from stimulation of islets by glucose, including L- and R-type Ca(2+) channel knockouts, as well as from Syntaxin-1A-deficient cells. We also use the model to investigate the relative contribution of calcium signaling and pool depletion in controlling biphasic secretion.
Immobilization of activated sludge for the degradation of phenol (1999)

Abstract Activated sludge obtained from a phenol treatment plant was immobilized by entrapment in Ca‐alginate, chemical or radiation polymerised polyacrylamide, agarose and hen egg white. All these techniques resulted in immobilized sludge preparations retaining their phenol degrading ability. Comparatively Ca‐ alginate entrapped sludge retained maximum activity. The immobilized sludge could be reused over 12 batches without loss in phenol degrading ability. Immobilization of the sludge provided protection to the micro flora and could efficiently degrade phenol concentrations over 1000 ppm better than the free sludge. Key words: Activated sludgeimmobilizationphenol degradationCa‐alginatepolyacrylamidehen egg white
In Vitro Evaluation of Hepatic and Extra-hepatic Metabolism of Coumarins Using Rat Subcellular Fractions: Correlation of In Vitro Clearance with In Vivo Data (2008)

7-Ethoxycoumarin (7-EC) and 7-hydroxycoumarin (7-HC) were chosen as model compounds to study hepatic and extra-hepatic metabolism in rat tissue subcellular (microsomal and S9) fractions and to scale the observed in vitro clearance to in vivo plasma clearance. 7-EC and 7-HC showed significant metabolic degradation in liver subcellular fractions as compared to subcellular fractions obtained from intestine, kidney, lung and brain. The total in vitro metabolic clearance for 7-EC and 7-HC was determined by adding the individual in vitro organ clearance values obtained in hepatic and extra-hepatic microsomes or S9 fractions. The predicted in vivo clearance for 7-HC was 63.6 and 81.6 ml/min/kg by in vitro scaling from microsomes and S9 fractions, respectively. For 7-EC, the values were 78.5 and 76.8 ml/min/kg, respectively. The predicted clearance was found to be reasonably accurate with slight over- and underprediction. Interestingly, the relative contribution of hepatic and extra-hepatic metabolism to the total clearance of 7-EC and 7-HC was remarkably high, ranging from 62-77% and 22-38%, respectively, of the total metabolic clearance. It is concluded that the model of multi-organ subcellular fractions is a useful in vitro tool for the prediction of in vivo metabolic clearance, as it can provide information about the relative contribution of extra-hepatic and hepatic metabolism to total metabolic clearance.
Resource management and quality of service in third generation wireless networks (2001)

The third generation networks and services present opportunities to offer multimedia applications and services that meet end-to-end quality of service requirements. The key parts of the standards are already in place, and limited 3G services have already been turned on. While the evolution to 3G occurs, many operators will implement 2.5G interim solutions for a good period of time. We discuss the various evolution scenarios from the present 2G networks to 3G networks. Then we present the UMTS QoS architecture and its requirements, followed by a discussion on QoS in 3G air interfaces, radio access network, and core network.
How Effective Are Electronic Reputation Mechanisms? An Experimental Investigation (2004)

Electronic reputation or “feedback” mechanisms aim to mitigate the moral hazard problems associated with exchange among strangers by providing the type of information available in more traditional close-knit groups, where members are frequently involved in one another's dealings. In this paper, we compare trading in a market with online feedback (as implemented by many Internet markets) to a market without feedback, as well as to a market in which the same people interact with one another repeatedly (partners market). We find that while the feedback mechanism induces quite a substantial improvement in transaction efficiency, it also exhibits a kind of public goods problem in that, unlike in the partners market, the benefits of trust and trustworthy behavior go to the whole community and are not completely internalized. We discuss the implications of this perspective for improving feedback systems.
Attempted Disintegration of Calculi by Ultrasonic Vibrations (1953)

No AccessJournal of Urology1 Nov 1953Attempted Disintegration of Calculi by Ultrasonic Vibrations William P. Mulvaney William P. MulvaneyWilliam P. Mulvaney View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)67971-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1953 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByMulvaney W (2018) The Hydrodynamics of Renal Irrigations: With Reference to Calculus SolventsJournal of Urology, VOL. 89, NO. 6, (765-768), Online publication date: 1-Jun-1963.Coats E (2018) The Application of Ultrasonic Energy to Urinary and Biliary CalculiJournal of Urology, VOL. 75, NO. 5, (865-874), Online publication date: 1-May-1956. Volume 70Issue 5November 1953Page: 704-707 Advertisement Copyright & Permissions© 1953 by The American Urological Association Education and Research, Inc.MetricsAuthor Information William P. Mulvaney More articles by this author Expand All Advertisement PDF DownloadLoading ...
Improved speed control of Permanent Magnet Synchronous Machine at overmodulation region (2012)

In Permanent Magnet Synchronous Machine (PMSM) drives, linear region, which is inside the inscribed circle of the voltage hexagon in the voltage plane, is mainly used for the stable operation. To enhance torque capability under the limited input DC link voltage, the region outside the inscribed circle of the voltage hexagon, known as overmodulation region, can be exploited in the flux-weakening operation. However, the operation of drive system in the overmodulation region cannot be free from the degradation of speed control performance. This paper presents investigations on control issues in the overmodulation region and proposes an algorithm for improving the speed control performance in the overmodulation region. The effectiveness of the proposed method is verified by computer simulations and experiments.
Purification and properties of an acid endo-1,4-β-glucanase from Bacillus sp. KSM-330 (1991)

A novel acid cellulase (endo-1,4-beta-glucanase, EC 3.2.1.4) was found in a culture of Bacillus sp. KSM-330 isolated from soil. One-step chromatography on a column of CM-Bio-Gel A yielded a homogeneous enzyme, as determined by silver staining of both sodium dodecyl sulphate (SDS) and nondenaturing gels. The enzyme had a molecular mass of 42 kDa, as determined by SDS-polyacrylamide gel electrophoresis. The isoelectric point was higher than pH 10. The N-terminal amino acid sequence of the enzyme was Val-Ala-Lys-Glu-Met-Lys-Pro-Phe-Pro-Gln-Gln-Val-Asn-Tyr-Ser-Gly-Ile-Leu- Lys-Pro . This enzyme had an optimum pH for activity of 5.2, being active over an extremely narrow range of pH values, from 4.2 to 6.9; below and above these pH values no activity was detectable. The optimum temperature at pH 5.2 was around 45 degrees C. The enzyme efficiently hydrolysed carboxymethylcellulose (CMC) and lichenan, but more crystalline forms of cellulose, curdlan, laminarin, 4-nitrophenyl-beta-D-glucopyranoside and 4-nitrophenyl-beta-D-cellobioside were barely hydrolysed. The enzymic activity was inhibited by Hg2+ but was not affected by other inhibitors of thiol enzymes, such as 4-chloromercuribenzoate. N-ethylmaleimide and monoiodoacetate. N-Bromosuccinimide abolished the enzymic activity, and CMC protected the enzyme from inactivation by this tryptophan-specific oxidant. It is suggested that a tryptophan residue(s) is involved in the mechanism of action of the Bacillus cellulase and that the inhibition of enzymic activity by Hg2+ is ascribable to interactions with the tryptophan residue(s) rather than with thiol group(s).
Randomness and degrees of irregularity. (1996)

The fundamental question "Are sequential data random?" arises in myriad contexts, often with severe data length constraints. Furthermore, there is frequently a critical need to delineate nonrandom sequences in terms of closeness to randomness--e.g., to evaluate the efficacy of therapy in medicine. We address both these issues from a computable framework via a quantification of regularity. ApEn (approximate entropy), defining maximal randomness for sequences of arbitrary length, indicating the applicability to sequences as short as N = 5 points. An infinite sequence formulation of randomness is introduced that retains the operational (and computable) features of the finite case. In the infinite sequence setting, we indicate how the "foundational" definition of independence in probability theory, and the definition of normality in number theory, reduce to limit theorems without rates of convergence, from which we utilize ApEn to address rates of convergence (of a deficit from maximal randomness), refining the aforementioned concepts in a computationally essential manner. Representative applications among many are indicated to assess (i) random number generation output; (ii) well-shuffled arrangements; and (iii) (the quality of) bootstrap replicates.
Numerical Study of the Effects of Hydrocarbon Addition and Corresponding Chemical Kinetics on the Promotion of NO Oxidation in Nonthermal Plasma DeNOx Treatment (2000)

In the present study, a systematic chemical kinetic calculations were made to investigate the augmentation of conversion due to the addition of various hydrocarbons (methane, ethylene, ethane, propylene, propane) in the nonthermal plasma treatment. It is included in the present conclusion that the reaction between hydrocarbon and oxygen radicals induced by electron collision, is believed to be a primarily process for triggering the overall NO oxidation and the eventual NOx reduction. Upon the completion of the initiating step, various radicals (OH, etc.) successively are produced by hydrocarbon decomposition form the primary path of conversion. When the initiating step is not activated, hydrocarbon consumption rate appeared to be very low, thereby the targeted level of NO conversion can only be achieved by the addition of more input energy. Present study showed ethylene and propylene to have higher affinity with O radical under all conditions, thereby both of these hydrocarbons show very fast and efficient oxidation. It was also shown that propylene is superior to ethylene in the aspect of NOx removal.
User interest modeling by labeled LDA with topic features (2011)

As well known, the user interest is carried in the user's web browsing history that can be mined out. This paper presents an innovative method to extract user's inter.ests from his/her web browsing history. We first apply an efficient algorithm to extract useful texts from the web pages in user's browsed URL sequence. We then proposed a Labeled Latent Dirichlet Allocation with Topic Feature (LLDA-TF) to mine user's interests from the texts. Unlike other works that need a lot of training data to train a model to adopt supervised information, we directly introduce the raw supervised information to the procedure of LLDA-TF. As shown in the experimental results, results given by LLDA-TF fit predefined categories well. Furthermore, LLDA-TF model can name the user interests by category words as well as a keyword list for each category.
Whistle-Blowing: Effective and Ineffective Coping Responses (1999)

How do nurses respond when they identify misconduct in patient care settings? The authors used a descriptive survey (N = 95) to identify effective coping strategies of whistle-blowers (n = 70) and non-whistle-blowers (n = 25). Results identified four effective coping strategies used by whistle-blowers. The authors offer recommendations to nurses who encounter misconduct in their workplace.
The temporal distribution of road accidents in adverse weather (1999)

This paper undertakes a preliminary study into the temporal recording of road accidents in adverse weather. Monthly police accident data, by county, have been utilised for England and Wales, and weather-related road accident findings compared with the general weather patterns experienced over the British Isles. The results show that seasonal patterns to weather-related road accidents match the occurrence of hazardous conditions, with regional variations to weather patterns identifiable within the accident data. Copyright © 1999 Royal Meteorological Society
Ultrasound Augmented Thrombolysis (2005)

Recent developments in thrombolysis include transcutaneous ultrasound augmentation of tissue plasminogen activator (tPA) activity and microbubble augmented ultrasound lysis. While standard thrombolytic drugs are well-known, the increased thrombolytic drug activity with the addition of ultrasound is a new clinical tool early in development. The therapeutic thrombolytic action of ultrasonographic microbubble contrast agents and a beam of ultrasound when in contact with clot is also a technique rapidly developing and not widely appreciated. Both augmentation techniques have progressed to early clinical use. The use of directed ultrasound beams to increase lytic activity in a specific target with either technique may lead to fewer hemorrhagic complications, especially in anatomical areas remote from the target. The combination of intravenous tPA and directed ultrasound is very promising in the treatment of ischemic stroke in human trials, and microbubble augmented ultrasound thrombolysis has been proven effective in several animal models of stroke and clotted dialysis grafts, with phase I/II trials in human dialysis grafts, arteries, and veins ongoing. This paper will review the state-of-the-art in this rapidly progressing field.
Medium access control and radio resource management for packet data services over IS-136 channels (2003)

This paper provides an overview of the flexible, high performance packet data channel (PDCH) that has been designed for high rate packet data services over IS-136 TDMA channel. To achieve the highest data rates in the limited 30 kHz channel bandwidth, the packet data channel is designed for adaptive modulation and in addition to a fixed coding mode, permits operation using an incremental redundancy mode.
Ploidy changes and genome stability in yeast (2014)

Eukaryotic organisms maintain karyotypes with constant chromosome number, but polyploid cells that contain more than two sets of chromosomes can frequently be found. On the one hand, polyploidization is likely to provide some beneficial effects, as naturally occurring polyploid cells can be readily found. On the other hand, polyploidization profoundly affects cell physiology, which may be detrimental to cells. Additionally, polyploidy leads often to aneuploidy and diversification of genetic information; therefore, it has always been considered a prominent driving force in evolution. Recently tetraploid-derived aneuploidy was suggested as a possible mechanism for resistance to fungicides. Another prominent example of the effects of tetraploid-derived aneuploidy is cancer, in which up to one-third of tumours likely originate through tetraploid intermediates. Studying the cellular consequences of polyploidization in human cells is challenging. In contrast, polyploid and aneuploid cells can be easily generated and analysed in the budding yeast Saccharomyces cerevisiae as well as in other yeast species. This, together with the naturally occurring yeast polyploids and aneuploids, provides a valuable model to study the effects of abnormal chromosome numbers on cellular physiology. Thus, the yeast model may provide novel insights into the general mechanisms of genomic instability in eukaryotes and improve our understanding of the consequences of ploidy changes and their relevance for disease.
Estimation of Forest Stand Characteristics Using Spectral Histograms Derived from an Ikonos Satellite Image (2008)

The aim of this paper was to examine the potential of Ikonos satellite images for estimating boreal forest stand characteristics using frequency distributions of radiometric values. The spectral features selected for use in the estimation were medians, standard deviations, and the parameters of the two-parametric Weibull distribution derived from the standwise spectral histograms of the Ikonos image. Ancillary map information, such as land-use and peatland classes, was also included. The method of estimation was non-parametric k-most similar neighbors (K-MSN) method. The most accurate results were achieved using spectral features that were derived from the multispectral images. The lowest RMSES for the mean total stem volume, basal area, and mean height were 52.2 m 3 /ha (31.3 percent), 5.6 m 2 /ha (25.3 percent), and 3.1 m (20.6 percent), respectively. When only the panchromatic image was used in the analysis, the RMSEs for the mean total stem volume and basal area were about 3 percentage points higher. No differences in the mean height estimates were observed between the multispectral and panchromatic images. The most efficient predictor variables were the medians and the scale parameters of the Weibull distribution. The use of classified map information did not improve the results. The findings suggest that Ikonos satellite images can be used in to estimate forest stand characteristics giving an accuracy that corresponds to that achieved with aerial photographs.
Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia (1998)

The results support the concept of there being a defect in the fine structure of dendrites of pyramidal neurons, involving loss of spines, in schizophrenia and may help to explain the loss of cortical volume without loss of neurons in this condition, although the effect of neuroleptic drugs cannot be ruled out.
Effects of Cultivation Conditions on Folate Production by Lactic Acid Bacteria (2003)

A variety of lactic acid bacteria were screened for their ability to produce folate intracellularly and/or extracellularly. Lactococcus lactis, Streptococcus thermophilus, and Leuconostoc spp. all produced folate, while most Lactobacillus spp., with the exception of Lactobacillus plantarum, were not able to produce folate. Folate production was further investigated in L. lactis as a model organism for metabolic engineering and in S. thermophilus for direct translation to (dairy) applications. For both these two lactic acid bacteria, an inverse relationship was observed between growth rate and folate production. When cultures were grown at inhibitory concentrations of antibiotics or salt or when the bacteria were subjected to low growth rates in chemostat cultures, folate levels in the cultures were increased relative to cell mass and (lactic) acid production. S. thermophilus excreted more folate than L. lactis, presumably as a result of differences in the number of glutamyl residues of the folate produced. In S. thermophilus 5,10-methenyl and 5-formyl tetrahydrofolate were detected as the major folate derivatives, both containing three glutamyl residues, while in L. lactis 5,10-methenyl and 10-formyl tetrahydrofolate were found, both with either four, five, or six glutamyl residues. Excretion of folate was stimulated at lower pH in S. thermophilus, but pH had no effect on folate excretion by L. lactis. Finally, several environmental parameters that influence folate production in these lactic acid bacteria were observed; high external pH increased folate production and the addition of p-aminobenzoic acid stimulated folate production, while high tyrosine concentrations led to decreased folate biosynthesis.
Inhibition of proliferation of primary avian fibroblasts through expression of histone H5 depends on the degree of phosphorylation of the protein (1991)

International audience
Rotating Disk Electrode Measurements on the CO Tolerance of a High‐Surface Area Pt/Vulcan Carbon Fuel Cell Catalyst (1999)

We examine the electrocatalytic properties of a Pt/Vulcan carbon catalyst toward the electro‐oxidation of CO and mixtures under proton exchange membrane fuel cell (PEMFC) relevant conditions (60 to 80°C, continuous reactant flow), employing rotating disk electrode (RDE) measurements. We demonstrate that our recently introduced thin‐film RDE technique can be applied to predict the performance of real fuel cell anodes operating on CO‐contaminated . The method involves attaching the catalyst particles to a glassy carbon RDE via a thin Nafion film. The thin‐film RDE technique opens the possibility for the mass‐transport‐free determination of the electrode kinetics at 100% catalyst utilization. At identical mass‐specific current densities, the overpotentials for oxidation measured with the thin‐film RDE technique are in excellent agreement with performance data from PEMFC anodes. The kinetics of pure CO oxidation were investigated with mixtures, revealing that the CO oxidation activity increases with decreasing CO partial pressure (negative reaction order). The observed ignition potential for CO oxidation was the same for both the and the mixtures. Two oxidation mechanisms in the presence of CO can be distinguished: (i) a high Tafel slope region at low overpotentials, where oxidation occurs in vacancies of the CO adlayer; and (ii) a low Tafel slope region at high overpotentials where and CO oxidation occur simultaneously. © 1999 The Electrochemical Society. All rights reserved.