gebhart/patrepeval huggingface dataset:
ACID AND BILE TOLERANCE, ADHESION TO EPITHELIAL CELLS OF PROBIOTIC MICROORGANISMS (2010)

Toleranţa faţa de aciditatea gastrica si faţa de sarurile biliare, precum si adeziunea bacteriiloor probiotice la celulele epiteliale sunt considerate condiţii minime necesare pentru un efect benefic asupra starii de sanatate. Rezistenţa tulpinilor Lactobacillus casei 01 si Lactobacillus acidophilus La-5 la pH=2-4 si la o concentraţie de saruri biliare 0,3-1,0%, precum si adeziunea lor la celule IEC-6 a fost verificata in vitro. Capacitatea de adeziune a tulpinilor a fost evidenţiata cu metoda coloraţiei Gram. Tulpina L. casei 01 prezinta o sensibilitate mai ridicata la aciditatea gastrica decât L. acidophilus La-5. L. casei este foarte sensibila faţa de saruri biliare. Ambele tulpini prezinta o capacitate buna de adeziune la celule epiteliale. Tolerance to gastric acidity, bile salts and adhesion of probiotic bacteria to intestinal epithelial cells is regarded as a prerequisite to exert beneficial health effects. Resistance to pH 2–4 and 0,3–1% bile salt concentration of Lactobacillus casei 01, Lactobacillus acidophilus La-5, as well as adhesion of strains to IEC-6 cell line were investigated in vitro. The adhesion ability of the tested strains was quantified with Gram-staining method. L. casei 01 presents increased sensibility to gastric acidity than L. acidophilus La-5. L. casei 01 is very sensitive to action of bile salts. Both strains show good adhesion ability to epithelial cells.
REGULATION OF THE IMMUNE RESPONSE (1973)

The specificity of antigen recognition by thymus-derived helper cells (T cells) and antibody was examined in mice, heterologous erythrocyte antigens from sheep (SRBC), goat (GRBC), burro (BRBC), chicken (CRBC), and toad (TRBC) being used. Antibody specificity was tested by a number of functional assays: hemagglutination, hemolysis, and immune suppression. The specificity of T cells was determined by titrating their ability to help the in vitro antitrinitrophenol (TNP) responses of mouse spleen cultures immunized with the hapten coupled to the various test erythrocytes as carrier. Anti-SRBC antibody cross-reacted with GRBC, but not with BRBC, CRBC, or TRBC. In contrast, SRBC-primed helper T cells cross-reacted with both GRBC and BRBC, but not with CRBC or TRBC, indicating a difference in the specificity of antigen recognition between the cellular and the humoral immune responses.
Application of Agilent 2100 Bioanalyzer in detection of human papilloma virus. (2003)

Agilent 2100 Bioanalyzer combined with PCR is specific, accurate and sensitive for HPV detection and genotyping.
Design verification of an 18-million-transistor digital television and media processor chip (2002)

This paper describes the verification methodology that has been followed in the design of NX-2700 - a digital television and media processor chip from Philips Semiconductors. Targeted at the digital television (DTV) markets, the NX-2700 processor not only supports all of the eighteen ATSC DTV formats, from standard-definition to wide-angle, high-definition video, but has also the power to handle video and audio source decoding (high-level MPEG-2, AC-3 and ProLogic audio, closed captioning, etc.). Featuring a programmable, general-purpose VLIW CPU core (that implements many non-trivial multimedia algorithms, coordinates all on-chip activities, and runs a small real-time operating system), NX-2700 is a true example of a system-on-a-chip; the CPU core, aided by an array of peripheral devices (multimedia co-processors and input-output units) and high-performance buses, facilitates concurrent processing of audio, video, graphics, and communication-data.
A Proposal on Video Editing System Coping with Rights Inheritance Management for Secondary Content (2008)

This paper presents a video editing system based on the proposed rights inheritance framework for generating a secondary content. We propose rights inheritance content editor (RICE) module that provides the editing control with digital rights management (DRM) according to the granted rights during the authoring process, and manages inherited rights generation for derived contents. With our proposed rights inheritance framework and RICE, a secondary content can be generated respecting the rights of original contents.
Substitution of wheat flour with rice flour and rice bran in flake products: effects on chemical, physical and antioxidant properties. (2009)

Abstract: Rice flour and rice bran were used to substitute wheat flour in flake product in order to increase the nutrition value to consumers and add value to rice grain. Mixture design was applied to generate the various
Flexibilidad y el centro corporal: estiramientos dinámicos y estáticos para el centro corporal (2004)

Muchos entrenadores, preparadores y atletas están incorporando algún tipo de entrenamiento para la zona central con la idea de mejorar el rendimiento deportivo. Esos ejercicios trabajan los grandes grupos musculares en el centro del cuerpo (abdominales, oblicuos y erectores espinales entre otros) que conforman lo que llamamos el centro corporal. Estos músculos y muchos otros músculos pequeños con función estabilizadora son los responsables para estabilizar y equilibrar el cuerpo tanto en su función postural (estática) como el movimiento (dinámica). Sin embargo todavía quedan por descubrir muchos aspectos para que los atletas sepan cómo implementar una rutina de estiramientos dinámica para el centro corporal en sus programas de entrenamiento¿ Al realizar una rutina de estiramientos dinámicos en tu programa, disminuirás el riesgo de lesión (ejercicios incluidos)
Importance of microbial natural products and the need to revitalize their discovery (2013)

Microbes are the leading producers of useful natural products. Natural products from microbes and plants make excellent drugs. Significant portions of the microbial genomes are devoted to production of these useful secondary metabolites. A single microbe can make a number of secondary metabolites, as high as 50 compounds. The most useful products include antibiotics, anticancer agents, immunosuppressants, but products for many other applications, e.g., antivirals, anthelmintics, enzyme inhibitors, nutraceuticals, polymers, surfactants, bioherbicides, and vaccines have been commercialized. Unfortunately, due to the decrease in natural product discovery efforts, drug discovery has decreased in the past 20 years. The reasons include excessive costs for clinical trials, too short a window before the products become generics, difficulty in discovery of antibiotics against resistant organisms, and short treatment times by patients for products such as antibiotics. Despite these difficulties, technology to discover new drugs has advanced, e.g., combinatorial chemistry of natural product scaffolds, discoveries in biodiversity, genome mining, and systems biology. Of great help would be government extension of the time before products become generic.
CATALYTICALLY ENCHANCED SYSTEMS FOR HYDROGEN STORAGE (2007)

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Decision Hysteresis Reduces Digital P<sub>e</sub> (1972)

It is shown that the source statistics influence the form of the decision threshold in an optimum receiver. For a first-order Markov source, a simple suboptimum realization is a hysteresis loop. The performance improvement over the single threshold decision rule is modest but in some cases it is possible to cut the P <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">e</inf> in half. One case where decision hysteresis performs best is in a modem that uses split phase or data scrambling to ensure that the transmitted signal tends to alternate. As a practical matter, it turns out that hysteresis can do more damage than good if the signal-to-noise ratio is variable.
Novel KIND1 Gene Mutation in Kindler Syndrome With Severe Gastrointestinal Tract Involvement (2006)

Because of our experience with this and another patient, we propose that gastrointestinal tract involvement should be looked at more frequently in Kindler syndrome.
Cloning, Functional Expression, and Chromosomal Localization of the Human Pancreatic Islet Glucose-Dependent Insulinotropic Polypeptide Receptor (1995)

Glucose-dependent insulinotropic polypeptide (GIP) is a hormone secreted by the endocrine K-cells from the duodenum that stimulates glucose-induced insulin secretion. Here, we present the molecular characterization of the human pancreatic islet GIP receptor. cDNA clones for the GIP receptor were isolated from a human pancreatic islet cDNA library. They encoded two different forms of the receptor, which differed by a 27-amino acid insertion in the COOH-terminal cytoplasmic tail. The receptor protein sequence was 81% identical to that of the rat GIP receptor. When expressed in Chinese hamster lung fibroblasts, both forms of the receptor displayed high-affinity binding for GIP (180 and 600 pmol/l). GIP binding was displaced by < 20% by 1 mumol/l glucagon, glucagon-like peptide (GLP-I)(7-36) amide, vasoactive intestinal peptide, and secretin. However exendin-4 and exendin-(9-39) at 1 mumol/l displaced binding by approximately 70 and approximately 100% at 10 mumol/l. GIP binding to both forms of the receptor induced a dose-dependent increase in intracellular cAMP levels (EC50 values of 0.6-0.8 nmol/l) but no elevation of cytoplasmic calcium concentrations. Interestingly, both exendin-4 and exendin-(9-39) were antagonists of the receptor, inhibiting GIP-induced cAMP formation by up to 60% when present at a concentration of 10 mumol/l. Finally, the physical and genetic chromosomal localization of the receptor gene was determined to be on 19q13.3, close to the ApoC2 gene. These data will help study the physiology and pathophysiology of the human GIP receptor.
Covalent Analogues of DNA Base-Pairs and Triplets VII. Synthesis and Cytostatic Activity of Bis(purin-6-yl)acetylene and -diacetylene Nucleosides (2004)

The title bis(purin-6-yl)acetylene and -diacetylene nucleoside derivatives were prepared as covalent base-pair analogues starting from acyl-protected 6-ethynylpurine and 6-iodopurine nucleosides by the Sonogashira cross-coupling or oxidative alkyne-dimerization reactions followed by deprotection. The key starting acyl-protected 6-ethynylpurine nucleosides were prepared by a sequence of cross-coupling reactions of protected 6-halopurine nucleosides with (trimethylsilyl)acetylene followed by a modified desilylation with TBAF in presence of acetic acid. Surprisingly, the acyl-protected nucleosides exhibited significant cytostatic activity higher than the fully deprotected title compounds.
Chromatin modification and remodelling: a regulatory landscape for the control of Arabidopsis defence responses upon pathogen attack (2012)

Due to their sessile lifestyle, plants have to cope with an ever-changing environment and to defend themselves against a multitude of biotic aggressors that compromise their development and reproduction. Responses to various biotic stresses largely depend on the plant's capacity to modulate rapidly and specifically its transcriptome. In a stress type-dependent manner, external signals are translocated into the nucleus to activate transcription factors, resulting in the increased expression of particular sets of defence-related genes. Among mechanisms of transcriptional regulation, chromatin remodelling accomplished through the activity of histone-modifying enzymes and ATP-dependent chromatin-remodelling complexes is emerging as a key process in the orchestration of plant biotic stress responses. In this review, we summarize and discuss roles that chromatin-remodelling mechanisms may play in regulating Arabidopsis defence responses.
Effect of Level and Solubility of Soybean Protein on Its Utilization by Young Lambs (1969)

Growth, digestibility and nitrogen retention trials were conducted to study the effect of dry heating soybean protein to reduce its solubility on nutrient utilization in sheep. The soybean meal was heated at 149° C. for 4 hr. in a forced-air oven, which reduced protein solubility from 72 to 35%. Growth rate was highest at the 14 % protein level and heating the soybean meal had an inconsistent effect. Feed efficiency was improved significantly (P<.05) by feeding the heated soybean meal. Rumen ammonia concentrations increased with protein level in both trials and showed a slight depression due to heating the soybean meal.
Hormonal regulation of apoptosis and the Fas and Fas ligand system in human endometrial cells (2002)

The process of apoptosis is responsible for normal cellular turnover in numerous tissues throughout the body. The endometrial layer of the uterus shows steroid-dependent cyclic changes in structure and function. After a proliferative and secretory phase, steroid support is withdrawn and the uterine epithelium is shed. We hypothesize that the apoptosis observed in endometrial cells following hormonal withdrawal is mediated by the Fas/Fas ligand (FasL) system. Normal endometrial cells and endometrial cancer cells were cultured in the presence of estrogen and progesterone. In order to mimic physiological hormonal changes, estrogen and progesterone were removed from the media. Apoptosis was determined by 3-[4,5-dimethylthiazol-2-yl]-2,5-dephenyl tetrazolium bromide (MTT) assay and propidium iodide staining, while Fas and FasL expression were evaluated by Western blot analysis. The endometrial cells expressed Fas and low levels of FasL. Withdrawal of estrogen and/or progesterone from the culture induced apoptosis causing an approximately 50% decrease in cell viability. This coincided with increased Fas and FasL expression. Treatment of the cells with anti-FasL antibody prevented cell death following hormonal withdrawal. Estrogen and progesterone therefore represent survival factors which hamper cell death by impeding the expression of apoptotic factors. Our results indicate that Fas-mediated apoptosis is important for endometrial cycling and suggest that dysregulation of the Fas/FasL interactions may have an important role in the development of endometrial cancer.
ChemInform Abstract: NMR Spectroscopy for Chemical Analysis at Low Magnetic Fields (2014)

Abstract Review: 47 refs.
Semantic and object-oriented database support for software environments (2003)

In the database community there is considerable disagreement concerning the definition of 'object-oriented'. The author distinguishes between two very different ways in which this term is used in the database world, and argues that together, these two sorts of object-orientedness form a solid framework for supporting software engineering. Essentially, when database researchers use the word 'object-oriented', they are generally referring to one of two approaches-structural object-orientation or behavioral object-orientation. The former is usually called semantic modeling, after a class of data models that attempt to provide richer constructs for representing the semantics of database applications. The second class of data models is geared toward the behavior of objects and is concerned with the manipulation of data, taking an abstract data type approach of embedding operations (methods) within types.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Fabrication of Carbon-Encapsulated Mono- and Bimetallic (Sn and Sn/Sb Alloy) Nanorods. Potential Lithium-Ion Battery Anode Materials (2009)

Novel carbon-encapsulated mono- and bimetallic (Sn and Sn/Sb alloy) core−shell nanorods were synthesized as potential anode materials for future lithium-ion batteries by a reductive, thermochemical vapor deposition at different acetylene/nitrogen (1:9) gas flow rates (20, 30, and 200 sccm) between 750 and 810 °C over SnO2/Sb2O10 and SnO2 nanopowders. Their morphologies and structures were characterized by SEM and TEM. Nanorod morphologies varied depending on the acetylene flow rate. The outer carbon layer thickened with time. More irregular nonuniform growth occurred at longer growth periods at 810 °C, giving spherical, conical, bulblike, and/or lumpy structures containing various amounts of metal. Sharp powder X-ray diffraction (XRD) peaks proved that well-crystallized Sn metal and Sn/Sb alloy formed within the carbon shells. Certain conditions generated some SnO2 within the carbon shell. X-ray photoelectron spectroscopy (XPS) determined the elements present and their oxidation states. The main carbon peak in all nanorods was graphitic carbon. C1s and O1s high-resolution spectra confirmed a variety of oxygenated carbon species were present on the outer carbon surface region. The metallic core in the carbon-encased Sn nanorods contained Sn metal, SnO2, and possibly SnO (XPS), in good agreement with XRD measurements.
NBTI aware IG-FinFET based SRAM design using adaptable trip-point sensing technique (2014)

The progressive scaling demands effort from both the circuit and the device level, to cope with circuit variability and reliability issues. Advent of FinFET technology has suppresses the short channel effects and variability, but still suffers with self heating problem consequently increases temporal degradations. In this paper, we investigate severity of Negative Bias Temperature Instability (NBTI) and proposes an adaptable trip point sensing based compensation technique to satisfy performance metrics for NBTI aware Independent Gate (IG) FinFET based SRAM. Simulation results are carried out using HSPICE with PTM 32nm IG-FinFET technology demonstrate that threshold voltage deviates from its nominal value by 17%, causing 6% and 13% degradation in SNM and RNM, respectively under NBTI degradation at 125°C for 3 years. The proposed technique yields 42% reduced read failures under NBTI. Thus, proposed approach improves the stability of SRAM array during its operational life and hence, reliability of the system.
Tea pigments inhibit the production of type 1 (T<sub>H1</sub>) and type 2 (T<sub>H2</sub>) helper T cell cytokines in CD4<sup>+</sup> T cells (2002)

Tea pigments are oxidized products of polyphenols derived from tea leaves (Camellia sinensis). Theaflavins are constituents of tea pigments with antioxidant, antineoplastic and antiinflammatory properties similar to their parent compounds. The biological properties of polyphenols and theaflavins have been linked to their capacity to inhibit the activation of nuclear factor-kappaB (NF-kappaB), a transcription factor, which is critically involved in the molecular regulation of a number of proinflammatory cytokines. The current study examines the requirement for NF-kappaB in the immunosuppressive effects mediated by tea antioxidants. Specifically, we tested the hypothesis that cytokines produced by type 1 (T(H1)) CD4(+) T cells which require NF-kappaB for gene expression, such as interleukin-2 (IL-2) and interferon gamma (IFN gamma), are selectively inhibited by tea pigments. We found that tea pigments potently suppress IL-2 secretion, IL-2 gene expression and the activation of NF-kappaB in murine spleens enriched for CD4(+) T cells, as expected. Consistent with our hypothesis, tea pigments also inhibited the induction of IFNgamma mRNA. However, the expression of the T(H2) cytokines IL-4 and IL-5, which lack functional NF-kappaB sites within their promoters was unexpectedly suppressed by tea pigments, as well. The results indicate that NF-kappaB may be only one of multiple transcription factors inhibited by tea pigments.
Decision processes in agent-based automated contracting (2001)

The Magnet system meets many of the challenges of modeling decision making for customer agents in automated contract negotiation. In order to model decision making in the uncertain environment of contract negotiation, we use the Expected Utility Theory. We describe that theory, followed by more detailed descriptions of the customer agents' key decision-making processes and our search algorithm. First, we offer an overview of the Magnet environment.
Surgical tips for type II thyroplasty for adductor spasmodic dysphonia: modified technique after reviewing unsatisfactory cases (2010)

It was found that surgical failures or unsatisfactory results arise most frequently from certain clear mechanical faults. The critical procedures that most affected the results included: (1) incision and separation of the thyroid cartilage at the midline; (2) adjustment of separation width for optimal voice; (3) cartilage-perichondrium separation for holding an appropriate titanium bridge; and (4) installation and fixation of titanium bridges.
Vasopressin in Septic Shock (2011)

In recent years there has been growing interest in the use of vasopressin as an adjunctive vasopressor in septic shock. This review article aims to summarise the rationale for its use, review the evidence of its effects in clinical studies and consider future areas of research.
H∞-Optimal Control and Related Minimax Design Problems (2008)

“I believe that the authors have written a first-class book which can be used for a second or third year graduate level course in the subject... Researchers working in the area will certainly use the
Radiotherapy Promotes Tumor-Specific Effector CD8+ T Cells via Dendritic Cell Activation (2012)

Radiotherapy is an important treatment for cancer. The main mode of action is thought to be the irreversible damage to tumor cell DNA, but there is evidence that irradiation mobilizes tumor-specific immunity, and recent studies showed that the efficacy of high-dose radiotherapy depends on the presence of CD8(+) T cells. We show in this study that the efficacy of radiotherapy given as a single, high dose (10 Gy) crucially depends on dendritic cells and CD8(+) T cells, whereas CD4(+) T cells or macrophages are dispensable. We show that local high-dose irradiation results in activation of tumor-associated dendritic cells that in turn support tumor-specific effector CD8(+) T cells, thus identifying the mechanism that underlies radiotherapy-induced mobilization of tumor-specific immunity. We propose that in the absence of irradiation, the activation status of dendritic cells rather than the amount of tumor-derived Ag is the bottleneck, which precludes efficient anti-tumor immunity.
A GUI software design model and its runtime architecture for digital AV applications (2002)

In the field of digital AV equipment, the size of embedded software for the implementation of the graphical user interface (GUI) has increased. Also, as a remote controller is used as an input device, a GUI different from that of a computer using a mouse is required. We propose an example of applying the MVC model for GUI software design intended for remote controller operation, an efficient runtime architecture in line with this design model, and development tools. We also evaluated the improvement of software productivity when using this design model and its runtime architecture.
Piezoelectric ultrasonic motor using longitudinal-torsional composite vibration of a cylindrical resonator (2003)

A piezoelectric ultrasonic motor, which uses longitudinal and torsional composite vibration of a cylindrical resonator, was investigated. It was found that the resonant frequencies for longitudinal mode and torsional mode could coincide with each other in the cylindrical resonator, according to finite element analysis and experimental measurement. The motor using both resonant vibrations showed good performance. The 20-mm-diameter motor exhibited a 4 kgf-cm maximum torque, a 450-r.p.m maximum rotational speed, and a 40% maximum efficiency.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>