gebhart/patrepeval huggingface dataset:
Anti-Inflammatory and Anti-Allergic Activities of Pentaherb Formula, Moutan Cortex (Danpi) and Gallic Acid (2013)

Pentaherb formula (PHF) has been proven to improve the quality of life of children with atopic dermatitis without side effects. The aim of this study was to elucidate the potential anti-inflammatory and anti-allergic activities of PHF, Moutan Cortex (Danpi/DP) and gallic acid (GA) using human basophils (KU812 cells), which are crucial effector cells in allergic inflammation. PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p < 0.05). With the combined use of dexamethasone (0.01 μg/mL) and GA (10 μg/mL), the suppression of ICAM-1 expression and CCL5 and IL-6 release of IL-33-activated KU812 cells were significantly greater than the use of GA alone (all p < 0.05). The suppression of the IL-33-induced activation of intracellular signalling molecules p38 mitogen activated protein kinase, nuclear factor-kB and c-Jun amino-terminal kinase in GA-treated KU812 cells could be the underlying mechanism for the suppression on ICAM-1, chemokines and cytokines. The combined use of dexamethasone with the natural products PHF or DP or GA might therefore enhance the development of a novel therapeutic modality for allergic inflammatory diseases with high potency and fewer side effects.
Thermal Decomposition of Europium Hydroxide (1964)

The thermal decomposition of europium hydroxide in an air atmosphere was investigated by means of weight‐loss measurements, infrared spectroscopy, X‐ray diffraction analysis, and electron microscopy. These studies showed that EU(OH)° decomposed at temperatures between 225° and 300°C into EuOOH, which was stable up to about 425°C. Between 435° and 465°C this compound decomposed into cubic Eu 2 O 3 , which was stable until its inversion to the high‐temperature monoclinic form. X‐ray diffraction data were collected for Eu(OH) 3 and EuOOH and showed that the trihydroxide has a hexagonal crystal structure and the oxyhydroxide is possibly orthorhombic. The Eu(OH) 2 , EuOOH, and cubic EunOa powders contained particles up to several microns in size consisting of agglomerates of crystallites in the size range 200 to 400 A. The single monoclinic Eu 2 O 3 sample studied contained crystallites whose average size was greater than 2000 A.
p<i>‐Coumaroyltriacetic acid synthase, a new homologue of chalcone synthase, from </i>Hydrangea macrophylla<i> var. </i>thunbergii (1999)

Chalcone synthase and stilbene synthase are plant-specific polyketide synthases. They catalyze three common consecutive decarboxylative condensations and specific cyclization reactions. They are highly homologous to each other, and are likely to fall into a family of polyketide synthases along with acridone synthase and bibenzyl synthase. Two cDNA clones (named HmC and HmS), both of which show high homology to the known chalcone synthases, were obtained from leaves of Hydrangea macrophylla var. thunbergii. They were expressed in Escherichia coli in order to determine their enzyme functions. Detection of chalcone formation clearly indicated that HmC encoded chalcone synthase, while HmS protein catalyzed the formation of neither chalcone nor stilbene. However, a novel pyrone, a lactonization product of a linear tetraketide was detected in reaction products of HmS protein. This proves that HmS encodes a novel polyketide synthase that catalyzes only chain elongation without cyclization.
ANTI-infective Therapeutics from the Lepidopteran Model Host Galleria mellonella (2011)

The larvae of the greater wax moth Galleria mellonella prosper in use both as surrogate alternative model hosts for human pathogens and as a whole-animal-high-throughput-system for in vivo testing of antibiotics or mutant-libraries of pathogens. In addition, a broad spectrum of antimicrobial peptides and proteins has been identified in this insect during past decade among which some appear to be specific for Lepidoptera. Its arsenal of immunity-related effector molecules encompasses peptides and proteins exhibiting potent activity against bacteria, fungi or both, whose potential as new anti-infective therapeutics are presently being explored. Of particular interest is the insect metalloproteinase inhibitor (IMPI) which has been discovered in G. mellonella. The IMPI exhibits a specific and potent activity against thermolysin-like microbial metalloproteinases including a number of prominent virulence and/or pathogenic factors of human pathogens which are responsible for severe symptoms such as septicemia, hemorrhagic tissue bleeding, necrosis and enhancement of vascular permeability. The IMPI and antimicrobial peptides from G. mellonella may provide promising templates for the rational design of new drugs since evidence is available that the combination of antibiotics with inhibitors of pathogen-associated proteolytic enzymes yields synergistic therapeutic effects. The potential and limitations of insect-derived gene-encoded antimicrobial compounds as anti-infective therapeutics are discussed.
Battle for Chicago. By Wayne Andrews. New York: Harcourt, Brace and Company, 1946. Pp. ix, 358. $3.75. (1947)

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Detailed Characterization of a High‐molecular‐weight Glycoprotein Secreted by Lung Cancer Cells (1993)

A cancer-associated, high-molecular-weight glycoprotein antigen (6B3.Ag) recognized by monoclonal antibody 6B3 was purified from culture medium of human large cell lung carcinoma cell line (HLC-2) and characterized biochemically and immunochemically. The 6B3.Ag was purified more than 1,200-fold with a yield of 30% by salting out, precipitation by acidification at pH 4.5, and chromatographies on Sepharose 4B and concanavalin A-Sepharose. The molecular weight of 6B3.Ag is approximately 1,000,000 and the molecule is a homodecamer of 94,000 subunits. The 6B3.Ag is a glycoprotein containing 22.9% sugars, consisting of both N- and O-glycoside chains. The N-terminal 19 amino acids were determined and only 4 out of 19 amino acid residues were different from those of an antigen, L3, secreted by lung carcinoma cell line Calu-1. The serum level of 6B3.Ag was determined in normal adults as well as patients with various diseases by enzyme-linked immunosorbent assay. The mean serum level of 6B3.Ag was 3.1 micrograms/ml, ranging from 1.6 to 6.2 micrograms/ml in 131 healthy adults. When the cut-off value was set at 6.2 micrograms/ml, the incidence of positive values in the sera was elevated not only in malignant diseases such as hepatoma (73%) and leukemia (62%), but also in benign diseases such as chronic hepatitis (42%) and liver cirrhosis (63%). While the incidence of positive values was elevated in advanced liver diseases, namely, chronic hepatitis, liver cirrhosis and hepatoma, the cancer specificity of 6B3.Ag did not appear to be high.
Characterizing Variation of Branch Angle and Genome-Wide Association Mapping in Rapeseed (Brassica napus L.) (2016)

Changes in the rapeseed branch angle alter plant architecture, allowing more efficient light capture as planting density increases. In this study, a natural population of rapeseed was grown in three environments and evaluated for branch angle trait to characterize their phenotypic patterns and genotype with a 60K Brassica Infinium SNP array. Significant phenotypic variation was observed from 20 to 70°. As a result, 25 significant quantitative trait loci (QTL) associated with branch angle were identified on chromosomes A2, A3, A7, C3, C5, and C7 by the MLM model in TASSEL 4.0. Orthologs of the functional candidate genes involved in branch angle were identified. Among the key QTL, the peak SNPs were close to the key orthologous genes BnaA.Lazy1 and BnaC.Lazy1 on A3 and C3 homologous genome blocks. With the exception of Lazy (LA) orthologous genes, SQUMOSA PROMOTER BINDING PROTEIN LIKE 14 (SPL14) and an auxin-responsive GRETCHEN HAGEN 3 (GH3) genes from Arabidopsis thaliana were identified close to two clusters of SNPs on the A7 and C7 chromosomes. These findings on multiple novel loci and candidate genes of branch angle will be useful for further understanding and genetic improvement of plant architecture in rapeseed.
Kinetics of Fe(III) Reduction by Ascorbic Acid in Aqueous Solutions (2000)

The reaction of Fe(III) and ascorbic acid (AA) in food products and digestive tracts affects the efficiency and uptake of these two nutrients. We investigated the kinetics of Fe(III) reduction by AA at pH 5 and 6 in a model system at 25 degrees C. The results indicate that the reduction of Fe(III) by AA is of zero order with respect to AA. The reaction order with respect to Fe(III) cannot be represented by a simple kinetic model at pH 5 or 6. The major stage of the reduction (about 80%, stoichiometrically), however, could be represented by a general equation of -d[Fe(III)]/dt = k[Fe(III)],(1. 811) where k is a rate constant and [Fe(III)] is the total ferric concentration. The rate constant decreased 1 order of magnitude as pH increased from 5 to 6. Aging of Fe(III) solution slows its reduction rate at pH 6 but not at pH 5.
Methods for improving quantitation of putamen uptake constant of FDOPA in PET studies. (1993)

To estimate the striatal uptake constant of [18F]-L-6-fluorodopa (FDOPA) in humans, we studied two methods that can account for the image resolution and the background level of FDOPA. These two methods utilize information obtained from multiple ROIs varying in size around the putamen and from profiles crossing the middle of the putamen. The estimation of the uptake constant was based on a model of one-dimensional activity variation. Simulated data were used to evaluate the adequacy of these two methods. Parametric images of FDOPA uptake constants were generated using Patlak analysis for five studies in normals and were then analyzed with the two methods. Results from the simulated data indicated a good agreement between the estimated values and the true simulated values. Results from studies in normals show stable estimates of the FDOPA uptake constant that are not affected by image resolution. The two methods were not sensitive to the misplacement of ROIs and profiles.
The Mechanism of Aconitase Action (1971)

Abstract Pig heart muscle aconitase has been purified to apparent homogeneity as judged by polyacrylamide gel electrophoresis and sedimentation in the ultracentrifuge. The protein has an s20,w = 6.16, a molecular weight of 89,000, a D20,w value of 6.68 x 10-7 cm2 per sec, a frictional ratio, f/f0, of 1.08, and an isoelectric point of 9.1. The presence of 1.02 ± 0.11 moles of iron per 89,000 g of aconitase is revealed by atomic absorption spectroscopy. At 77°K, the electron spin resonance spectrum of aconitase has a signal at g = 4.1 arising from high spin iron(III). The iron(III) is thought to have a structural rather than a catalytic role since the electron spin resonance spectrum is unchanged upon addition of iron(II), cysteine, or citrate. The optical spectrum of aconitase shows a broad nonspecific absorption from 300 to 600 nm at 25°. Aconitase specifically requires iron(II) for activity and the time-dependent activation by iron(II) is fit by the consecutive combination of 2 iron(II) ions with the enzyme. The transverse relaxation rate, 1/T2, of aconitase-bound iron(III) decreases with increasing temperature and the longitudinal relaxation rate, 1/T1, increases with temperature below 22° and decreases with increasing temperature above 22°, yielding a correlation time τc = 1 x 10-11 sec. The inequality of the longitudinal and transverse relaxation rates indicates that protons are rapidly exchanging (g6 x 105 sec-1) between bulk solvent and the coordination sphere of the iron(III). The molar relaxivity, 1/T1p[Fe], for aconitase (5900 m-1 sec-1) at 22° indicates that aconitase-bound iron(III) is about half as effective as free iron (III) in relaxing the protons of water. From the Solomon-Bloembergen equation and assuming an iron to proton distance of 2.4 ± 0.1 A from crystallographic data, it is calculated that 3 ± 1 water molecules remain in the inner coordination sphere of aconitase-bound iron(III).
Different Levels of T-Cell Receptor Triggering Induce Distinct Functions in Hepatitis B and Hepatitis C Virus-Specific Human CD4<sup>+</sup>T-Cell Clones (2001)

CD4(+) T cells play a major role in the host defense against viruses and intracellular microbes. During the natural course of such an infection, specific CD4(+) T cells are exposed to a wide range of antigen concentrations depending on the body compartment and the stage of disease. While epitope variants trigger only subsets of T-cell effector functions, the response of virus-specific CD4(+) T cells to various concentrations of the wild-type antigen has not been systematically studied. We stimulated hepatitis B virus core- and hepatitis C virus NS3-specific CD4(+) T-cell clones which had been isolated from patients with acute hepatitis during viral clearance with a wide range of specific antigen concentrations and determined the phenotypic changes and the induction of T-cell effector functions in relation to T-cell receptor internalization. A low antigen concentration induced the expression of T-cell activation markers and adhesion molecules in CD4(+) T-cell clones in the absence of cytokine secretion and proliferation. The expression of CD25, HLA-DR, CD69, and intercellular cell adhesion molecule 1 increased as soon as T-cell receptor internalization became detectable. A 30- to 100-fold-higher antigen concentration, corresponding to the internalization of 20 to 30% of T-cell receptor molecules, however, was required for the induction of proliferation as well as for gamma interferon and interleukin-4 secretion. These data indicate that virus-specific CD4(+) T cells can respond to specific antigen in a graded manner depending on the antigen concentration, which may have implications for a coordinate regulation of specific CD4(+) T-cell responses.
Optimizing detection of road furniture (pole-like object) in Mobile Laser Scanner data (2013)

Abstract. Due to the road safety problem is becoming more and more serious recent years, existing road safety assessment by using automatic method is necessary. Meanwhile, since the pole-like objects have large effect on road safety and are in high demand as facilities to be managed, the automatic pole-like objects extraction is becoming a hot issue. As a result, a robust, quick and automatic pole-like object detection algorithm in MLS data is proposed in this paper. Two datasets are tested to show performance of the proposed algorithm, it demonstrates that it is feasible to detect tree with an overall accuracy of over 92% and other pole-like object of 72% in dataset A and 82% of tree points and 75% of other pole points in dataset B.
X-RAY DIFFRACTION STUDIES OF COLD WORK IN METALS SOLID SOLUTIONS AND GRAIN BOUNDARIES TECHNICAL REPORT NO. 1, SCOPE II. Technical Report No. 1 (1950)

The dependence of measured broadening upon and 9 indicates that cold work -broadening is due primarily to distortion rather than fragmentation,, The inte grated intensities of the high order reflections are not decreased by cold work,,The effect is quite different from that of temperature vibration, and the term "frozen heat motion" is an incorrect description of cold work distortion,, Modem techniques allow measuring precisely the shape of a reflection rather than just the widtho A new method of Fourier analysis has been developed to get as much information as is possible from the x-ray data without making any a priori assumptions about cC the nature of cold work distortion.For cold-worked (70-30) a-brass filings the x-ray data indicate that the strains in any direction are inversely as the values of Young's modulus for that direction and hence that stress is roughly isotropic.Stress distribution functions are obtained using all of the powder pattern lines.'The root mean square averaged stress decreases with the distance of averaging, indi cating the non-uniform nature of the stresses and strains in cold-worked metal.A * rough calculation of stored elastic energy for a-brass gives 1.4 cal/gm.1.
Characterization of a new fibrinolytic enzyme from Eisenia foelida (2004)

PurposeTo obtain an effective drug for thrombolysis.MethodsSix components were isolated and purified from earthworm Eisenia foelida and named F1…F6 . The protein concentration of F1 was determined by Lowry method. The purity and M r of F1 were estimated by SDS-poly acrylamide gel deectrophoresis(SDS-PAGE). The fibrinolytic activity was determined by Fibrin plate method. BAEE, Chromozym PL and Chromozym t-PA were used as specific substrate to obtain the ΔA/(min.g) and Km of F1 .The sequence of N-terminus 15 amino acids was determined by Applied Biosystem 491 Protein Sequencer.ResultsThe purity and M r of F1 were 100% and 28 500 respectively. F1 displayed a strong fibrinolytic activity with fibrin plate method but could weakly hydrolyze Chromozym PL and Chromozym t-PA.The Km of Chromozym PL and Chromozym t-PA could'nt be detected .The Km of BAEE decomposed by F1 was 2.808 7×10 -2 mol/L. Its N-terminal amino acid sequence was IIGGSNASPGEFPWQ.ConclusionA new and effective fibrinolytic enzyme is obtained.
Model-Driven Reengineering Legacy Software Systems to Web Services (2005)

The advancement of internet technology enables legacy software systems to be reused across geographical boundaries. Web Services (WS) have emerged as a new component-based software development paradigm in a network-centric environment based on the Service Oriented Architecture (SOA), the open standard description language XML and transportation protocol HTML. Therefore, legacy software systems can incorporate WS technology in order to be reused and integrated in a distributed environment across heterogeneous platforms. In this paper, we present a comprehensive, systematic, automatable approach toward reengineering legacy software systems to WS applications, rather than rewriting the whole legacy software system from scratch in an ad-hoc manner.
A significant impact of host–guest stoichiometry on the extensibility of polyrotaxane gels (2015)

Modification of the guest polymer ends efficiently and substantially decreases the density of the threaded rings. The minimized ring density drastically facilitates chain sliding through the cross-links in polyrotaxane gels. This molecular design is like regulating the "pressure" of the rings confined in the interlocked architecture, which counteracts the sliding.
All solid-state hydrogen ion-selective electrode based on a conducting poly(pyrrole) solid contact (1994)

A potentiometric ion-selective electrode based on a solid conducting poly(pyrrole) contact and neutral carrier tri-n-dodecylamine membrane was developed. The effect of the poly(pyrrole) doping anion on the characteristic of the sensor is presented and discussed. The ion-selective H+ sensitive electrode with a solid poly(pyrrole) contact is characterized by having a good stability over both short and long periods of time. Selectivity coefficients for this electrode are slightly better than those for internal solution electrodes. Stability is also improved especially when compared with coated wire type electrodes. Responses are fast and nearly Nernstian within the pH range 2–12. All solid-state sensors with plastic tri-n-dodecylamine were used for pH determinations in blood serum.
Entrevista con el tenis de élite: Antonio Martínez : entrenador de Juan Carlos Ferrero (2003)

Antonio Martinez Cascales nos recibe en la academia Equelite: Juan Carlos Ferrero, para informar a los suscriptores sobre los cambios en el entrenamiento deportivo en el tenis durante los ultimos anos y profundizar en el entrenamiento de Ferrero. Programacion, psicologia, nutricion y viaje son algunos de los temas que se cubren en esta entrevista.
Voice parade procedures: optimising witness performance (2019)

Unfamiliar voice identification is error-prone. Whilst the investigation of system variables may indicate ways of boosting earwitness performance, this is an under-researched area. Two experiments were conducted to investigate how methods of presenting voices during a parade affect accuracy and self-rated confidence. In each experiment participants listened to a target voice, and were later asked to identify that voice from a nine-person target present or target absent parade. In Experiment 1, accuracy did not vary across parades comprising 15 or 30 s sample durations. Overall, when the target was present, participants correctly identified the target voice with 39% accuracy. However, when the target was absent, participants correctly rejected the parade 6% of the time. There was no relationship between accuracy and confidence. In Experiment 2, performance with a serial procedure, in which participants responded after hearing all nine voices, was compared with a sequential procedure, in which participants made a decision after listening to each voice. Overall accuracy was higher with the sequential procedure. These results highlight the importance of system variable research in voice identification. Different methods of presenting voices have the potential to support higher levels of accuracy than the procedure currently recommended in England and Wales.
Page-reRank: Using Trusted Links to Re-Rank Authority (2005)

Search engines like Google.com use the link structure of the Web to determine whether Web pages are authoritative sources of information. However, the linking mechanism provided by HTML does not allow the Web author to express different types of links, such as positive or negative endorsements of page content. As a consequence, search engine algorithms cannot discriminate between sites that are highly linked and sites that are highly trusted. We demonstrate our claim by running PageRank on a real world data set containing positive and negative links. We conclude that simple semantic extensions to the link mechanism would provide a richer semantic network from which to mine more precise Web intelligence.
Failure to Treat Life-Threatening Ventricular Tachyarrhythmias in Contemporary Implantable Cardioverter–Defibrillators (2017)

Complex and unanticipated interactions between manufacturer-specific features and generic programming can prevent therapy for VF. More data are needed to assess the risks and benefits of translating evidence-based detection parameters from one manufacturer to another.
Pelvic Inflammatory Disease (PID) (1996)

This article has no abstract.
A new descriptive clustering algorithm based on Nonnegative Matrix Factorization (2008)

Nonnegative Matrix Factorization (NMF) provides a way for finding a part-based representation of nonnegative data. An important property of NMF is that it can produce a sparse representation of the data; however, in some applications, especially in text clustering, the sparse representation always consists of separated words, which cannot explicitly express the meaning of the basis vector. This paper presents a new descriptive clustering algorithm based on NMF, called DC-NMF that can avoid this separated word problem. In our proposed method, we embrace the phrase-by-document matrix in addition to the commonly used term-by-document matrix. Then, we use conjunct gradient descent to minimize the mean squared error objective function. Finally, we describe each cluster with the highest weighted element corresponding to one particular phrase. Our experimental results indicate that our method can obtain more “pure” clusters than other methods.