gebhart/patrepeval huggingface dataset:
Robust intonation pattern classification in human robot interaction (2011)

We present a system for the classification of intonation patterns in human robot interaction. The system distinguishes questions from other types of utterances and can deal with additional reverberations, background noise, as well as music interfering with the speech signal. The main building blocks of our system are a multi channel source separation, robust fundamental frequency extraction and tracking, segmentation of the speech signal, and classification of the fundamental frequency pattern of the last speech segment. We evaluate the system with Japanese sentences which are ambiguous without intonation information in a realistic human robot interaction scenario. Despite the challenging task our system is able to classify the intonation pattern with good accuracy. With several experiments we evaluate the contribution of the different aspects of our system.
Adaptive Inflow Control System (2014)

This article presents the idea and realization for the unique Adaptive Inflow Control System being a part of well completion, able to adjust to the changing in time production conditions. This system allows to limit the flow rate from each interval at a certain level, which solves the problem of water and gas breakthroughs. We present the results of laboratory tests and numerical calculations obtaining the characteristics of the experimental setup with dual-in-position valves as parts of adaptive inflow control system, depending on the operating conditions. The flow distribution in the system was also studied with the help of three-dimensional computer model. The control ranges dependences are determined, an influence of the individual elements on the entire system is revealed.
Cytotoxic action mode of a novel porphyrin derivative isolated from harmful red tide dinoflagellate <i>Heterocapsa circularisquama</i> (2008)

Heterocapsa circularisquama is known to cause lethal effect on bivalves, but toxic effect on fish has not been reported yet. Recently, we have found that H. circularisquama has potent light-dependent hemolytic toxins. Based on the chemical structural analysis, one of the hemolytic toxins named H2-a was found to be a novel porphyrin derivative with similar structure to pyropheophorbide a methyl ester (PME), a well-known photoactive hemolytic agent (Miyazaki et al., Aquatic Toxicol. 2005;73:382--393). To clarify the cytotoxic action mode of H2-a, we examined the effects of H2-a on HeLa cells in comparison with PME. The cytotoxicities of both reagents were strictly light dependent, and no significant cytotoxic effects including cellular morphological changes were induced without light illumination. The dose response curves revealed that H2-a showed stronger cytotoxicity to HeLa cells than PME. Fluorescence microscopic observation suggested that H2-a tends to accumulate in the plasma membrane, whereas PME seems to distribute entire cytoplasm. Although PME induced typical apoptotic nuclear morphological changes and DNA fragmentation in HeLa cells, no such apoptosis-inducing ability of H2-a was observed. Among the radical scavengers, histidine significantly inhibited the cytotoxic activity of H2-a, suggesting the involvement of singlet oxygen in the cytotoxicity. These results suggest that the cytotoxic mechanism of H2-a is necrotic rather than apoptosis differing from PME, even though these are structurally quite similar to each other. The relatively high affinity of H2-a to the plasma membrane might result in the potent and quick cytotoxicity without induction of apoptotic signal transduction.
Adenocarcinoma Arising from Barrett's Esophagus after the Operation for Esophageal Achalasia. (2001)

われわれは28年前に食道あからしあに対し胃弁移植術を施行し, 術後2次的に発生したと考えられるBarrett上皮由来の2型噴門部食道腺癌を経験した. 症例は55歳の男性で嚥下困難を訴え, 上部消化管内視鏡にて噴門部に2型進行癌を認めた. 生検では, 腫瘍からは中分化型管状腺癌, 腫瘍周囲のるごーる不染領域からは円柱上皮が得られた. 術前診断で噴門部進行Barrett食道腺癌と診断し, 下部食道・噴門側胃切除脾摘術を施行した. 病理組織学的には, 腫瘍はBarrett上皮に囲まれた乳頭腺癌であり, 胃壁には胃弁移植術による筋層断裂, 食道壁にはあからしあに相当する所見が認められた. 本例においては食道あからしあに対する胃弁移植術に起因する逆流性食道炎がBarrett食道を形成し, さらに腺癌が発症したものと考えられた.
Infraestructuras de comunicaciones y energéticas en Andalucía. Deficiencias, cambios y perspectivas (2015)

Andalucía no ha visto aún terminados los planes de ejecuciones de obras infraestructurales públicas y privadas programadas en años anteriores y cuando aún existen graves deficiencias en ellas, tiene que analizar las nuevas realidades económicas mundiales y adaptar sus viejos y no concluidos proyectos a las nuevas perspectivas.Aquí pretendemos describir de manera breve los cambios que se anuncian, sus consecuencias para el territorio de la comunidad y las nuevas posibilidades que abren. Adelantamos desde este momento la necesidad de comenzar a tomar conciencia de ello porque el algunos casos añaden nuevas deficiencias a las ya existentes.
[P1–270]: A STREAMLINED PCR‐BASED FRAGMENT ANALYSIS ASSAY THAT RESOLVES BOTH SINGLE NUCLEOTIDE AND POLY‐T LENGTH POLYMORPHISMS AT APOE AND TOMM40 SUSCEPTIBILITY LOCI IN ALZHEIMER's DISEASE (2017)

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that progresses slowly over time. Previous studies have identified an AD susceptibility locus in a region that includes APOE and TOMM40. Of the three common APOE alleles, ε4 is the most informative but in only ∼25% of Caucasians. Independently, poly-T polymorphisms at rs10524523 of the TOMM40 gene have been reported to influence both age of onset in late-onset AD (LOAD) and measures of cognitive decline. Here we describe a rapid and reliable PCR-based assay that reports both APOE genotypes and TOMM40 poly-T length in a single workflow. Cell-line gDNA samples were acquired from the Coriell Institute (7 AD, 104 other) and Asuragen (11). Whole blood (72) and matched blood/buccal gDNA (14) was isolated from presumed healthy donors. Sample gDNA was PCR amplified using prototype AmplideX® reagents (Asuragen). Amplicons tagged with FAM (TOMM40) and HEX (APOE) were resolved by capillary electrophoresis (CE) on a 3500 xL (Thermo Fisher) after a 2.5kV injection and 20 min run. Genotypes were determined in separate color channels from peak size patterns (APOE) or the mobility of target amplicon relative to a calibration curve (TOMM40). Both APOE and TOMM40 PCR amplicons could be resolved from a single CE injection, simplifying both the workflow and data analysis. All six possible APOE genotypes could be correctly identified, and results were consistent across different operators and days. Further, APOE genotypes were concordant with reference calls for 207/208 samples. The TOMM40 poly-T repeat number was determined within a single nucleotide for all samples tested to at least 40Ts, enabling the differentiation of similarly-sized alleles and accurate categorization near allele length boundaries. For both markers, inputs as low as 5 ng could be reliably genotyped. PCR genotyping of APOE and TOMM40 is challenged by GC- and AT-rich sequence contexts, respectively. We report the first assay that combines the analysis of both AD markers into a rapid, streamlined, and high-throughput workflow and achieves reproducible, high-resolution and accurate genotypes. This technology has the potential to advance clinical research using a standardized assay that can harmonize results across laboratories.
Coaxial Metal Nano‐/Microcables with Isolating Sheath: Synthetic Methodology and Their Application as Interconnects (2010)

Synthesis of coaxial nano-/microcables has been an intensive research subject due to their heterogeneous structures, tuneable properties, and important applications in nano-/micrometer-scale electronic and optoelectronic devices. Research on the fabrication of nanocables via solution strategies has made great progress in the past few years. In this Research News article, rapidly emerging new solution strategies such as hydrothermal carbonization (HTC) and synergistic soft-hard templates (SSHTs) are highlighted. Unique and flexible coaxial nano-/microcables synthesized by those methods have obvious advantages such as long-term stability and their electrical transport properties, compared with bare counterparts, suggesting that they are potential candidates as interconnects in the future.
An onboard vacuum suction spilled oil recovery system (2005)

A vacuum suction oil skimming system has been studied. The system employs a high power vacuum blower for sucking high viscosity oil. Its applicability to an onboard oil recovery system has been experimentally investigated using small-size models as well as a large-size model. The suction performance has been measured and is given in terms of liquid suction rates, oil and water fraction, friction loss and liquid holdup in the riser pipe in various simulated conditions including wave and current. An emulsified heavy oil whose viscosity is as high as 300,000 mPa.s was used. The results shows that the vacuum suction is a suitable method for recovering the spilled oil on the sea surface since the system has better performance on a wavy surface than a calm water. This work also includes the system overview and a basic design strategy for a real-size onboard oil recovery system which will be installed on a new oil recovery vessel.
p54nrb Is a Transcriptional Corepressor of the Progesterone Receptor that Modulates Transcription of the Labor-Associated Gene, Connexin 43 (Gja1) (2009)

The progesterone receptor (PR) plays important roles in the establishment and maintenance of pregnancy. By dynamic interactions with coregulators, PR represses the expression of genes that increase the contractile activity of myometrium and contribute to the initiation of labor. We have previously shown that PTB-associated RNA splicing factor (PSF) can function as a PR corepressor. In this report, we demonstrated that the PSF heterodimer partner, p54nrb (non-POU-domain-containing, octamer binding protein), can also function as a transcription corepressor, independent of PSF. p54nrb Interacts directly with PR independent of progesterone. In contrast to PSF, p54nrb neither enhances PR protein degradation nor blocks PR binding to DNA. Rather, p54nrb recruits mSin3A through its N terminus to the PR-DNA complex, resulting in an inhibition of PR-mediated transactivation of the progesterone-response element-luciferase reporter gene. PR also repressed transcription of the connexin 43 gene (Gja1), an effect dependent on the presence of an activator protein 1 site within the proximal Gja1 promoter. Mutation of this site abolished PR-mediated repression and decreased the recruitment of PR and p54nrb onto the Gja1 promoter. Furthermore, knockdown p54nrb expression by small interfering RNA alleviated PR-mediated repression on Gja1 transcription, whereas overexpression of p54nrb enhanced it. In the physiological context of pregnancy, p54nrb protein levels decrease with the approach of labor in the rat myometrium. We conclude that p54nrb is a transcriptional corepressor of PR. Decreased expression of p54nrb at the time of labor may act to derepress PR-mediated inhibition on connexin 43 expression and contribute to the initiation of labor.
The structure of a new cyclosporin A solvated form (1996)

Abstract The structure of cyclosporin A dimethyl isosorbide solvate (C 62 H 111 N 11 O 12 · C 8 H 14 O 4 , CsA · DMI) was solved using direct methods and refined anisotropically to the R value of 0.091 for 7120 observed independent reflections. The title compound crystallizes in the monoclinic space group P 2 1 with lattice parameters a = 15.521(2) Å, b = 20.833(3) Å, c = 12.949(3) Å, β = 100.21(1)°, Z = 2. In comparison with the structures of CsA monohydrate or dihydrate, the molecular shape of CsA · DMI differs in the backbone conformation ( ψ 1 , ψ 7 , φ 8 ) and in the opposite MeBmt 1 side-chain orientation ( χ 1 ), which permits to form the new H-bond contact MeBmt 1 OH-Sar 3 CO. The H-bond contact d -Ala 8 NH-MeLeu 6 CO is absent in the structure of CsA · DMI.
Darstellung, Schwingungsspektren und Kristallstrukturanalyse von Di‐ und Trifluor‐tetramethylammonium‐Salzen (1986)

Abstract Ausgehend von den zugehörigen Aminen wurden die fluorsubstituierten Tetramethylammonium‐Salze (CH 3 ) 3 NCH 2 F + ( II ), (CH 3 ) 3 NCHF 2 + ( III ) und (CH 3 ) 3 NCF 3 + ( IV ) durch Quaternierung dargestellt. III bildet sich auch aus (CH 3 ) 3 N und Zn/CF 2 Br 2 /KF in Acetonitril. II, III und IV wurden durch KMR‐Spektroskopie charakterisiert und schwingungsspektroskopisch unter Einschluß einer Normalkoordinatenanalyse für IV untersucht. Von den Iodiden von III und IV wurden Kristallstrukturanalysen durchgeführt. In beiden Kationen sind die NCH 3 ‐Abstände im Schnitt ( III 1,508(2) Å; IV 1,514(5) Å) länger als die NCF‐Bindungen ( III 1,497(4) Å; IV 1,491(6)Å).
Fetal cardiovascular system as influenced by maternal smoking (1979)

Primary prevention of atherosclerosis should be initiated early in life, preferably in childhood. Nevertheless, it tends to be forgotten that a child has existed for nine months before birth, and that the newborn child might already have been exposed to agents capable of causing vessel damage. Studies of the umbilical artery, umbilical vein, and vessels of the placental villi (2, 3, 4, 5, 6) revealed that, in this portion of the fetal cardiovascular system, severe damage to the vessel wall is associated with maternal tobacco smoking during pregnancy. These alterations within the fetal cardiovascular system were never found in the children of non-smoking mothers. If similar changes occur in the other vessels of the newborn child, which it seems reasonable to expect, they might give rise to sequelae later in life. It should therefore strongly be advocated that pregnant women abandon tobacco smoking.
Applied Optimization with MATLAB Programming (2001)

Technology/Engineering/MechanicalProvides all the tools needed to begin solving optimization problems using MATLAB The Second Edition of Applied Optimization with MATLAB Programming enables readers to harness all the features of MATLAB to solve optimization problems using a variety of linear and nonlinear design optimization techniques. By breaking down complex mathematical concepts into simple ideas and offering plenty of easy-to-follow examples, this text is an ideal introduction to the field. Examples come from all engineering disciplines as well as science, economics, operations research, and mathematics, helping readers understand how to apply optimization techniques to solve actual problems. This Second Edition has been thoroughly revised, incorporating current optimization techniques as well as the improved MATLAB tools. Two important new features of the text are:Introduction to the scan and zoom method, providing a simple, effective technique that works for unconstrained, constrained, and global optimization problems New chapter, Hybrid Mathematics: An Application, using examples to illustrate how optimization can develop analytical or explicit solutions to differential systems and data-fitting problemsEach chapter ends with a set of problems that give readers an opportunity to put their new skills into practice. Almost all of the numerical techniques covered in the text are supported by MATLAB code, which readers can download on the text's companion Web site www.wiley.com/go/venkat2e and use to begin solving problems on their own.This text is recommended for upper-level undergraduate and graduate students in all areas of engineering as well as other disciplines that use optimization techniques to solve design problems.
A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies <i>Taq</i>I RFLPs (1993)

A human vesicular monoamine transporter cDNA has been identified by screening a human brainstem library using sequences from the rat brain synaptic vesicle monoamine transporter (SVMT) [(1992) Cell 70, 539-551; (1992) Proc. Natl. Acad. Sci. USA 89, 10993-10997]. The hSVMT shares 92% amino acid identity with the rat sequence, but displays one less consensus site for asparagine N-linked glycosylation and one more consensus site for phosphorylation by protein kinase C. The human SVMT gene maps to chromosome 10q25 using Southern blotting analysis of human/rodent hybrid cell lines and fluorescent in situ hybridization approaches. The cDNA, and a subclone, recognize TaqI polymorphisms that may prove useful to assess this gene's involvement in neuropsychiatric disorders involving monoaminergic brain systems.
Measuring delirium severity in older general hospital inpatients without dementia. The Delirium Severity Scale. (1998)

The authors evaluated the validity, reliability, and sensitivity to change of the Delirium Severity Scale (DSS), a 10-minute assessment consisting of Forward Digit Span and Similarities. Twenty-two older inpatients with delirium but not dementia and 15 control patients were administered the DSS during hospitalization. Scores were significantly inversely correlated with experts' quantitative ratings of severity at all three time-points examined. The DSS showed significant improvement over time (P < 0.001) and significant correlation with improvement in expert ratings (P = 0.026). The DSS shows promise as a valid and reliable measure sensitive to changing symptom severity.
Tailored Nanostructuring of End‐Group‐Functionalized High‐Density Polyethylene Synthesized by an Efficient Catalytic Version of Ziegler’s “Aufbaureaktion” (2012)

Monoguanidinato titanium complexes are efficient catalysts to make OH end-group-functionalized polyethylene (PE-OH) by a catalyzed version of Ziegler's "Aufbaureaktion". This PE-OH can be structured to mesoporous polyethylene or polyethylene nanofibers/ribbons through diblock copolymer synthesis, microphase separation, and etching of the sacrificial polylactide block.
Some properties of the E matrix in two-view motion estimation (1989)

In the eight-point linear algorithm for determining 3D motion/structure from two perspective views using point correspondences, the E matrix plays a central role. The E matrix is defined as a skew-symmetrical matrix (containing the translation components) postmultiplied by a rotation matrix. The authors show that a necessary and sufficient condition for a 3*3 matrix to be so decomposable is that one of its singular values is zero and the other two are equal. Several other forms of this property are presented. Some applications are briefly described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Laboratory Diagnosis of Autoimmune Encephalitis (2016)

Autoimmune encephalitis is a group of encephalitis syndromes that cause altered mentality, memory decline, or seizures in association with the presence of serum and cerebrospinal fluid (CSF) autoantibodies (auto-Abs). An early diagnosis enables early treatments. The detection of auto-Abs is a confirmatory diagnosis. Tissue-based assay, cell-based immunoassay, and immunoblotting are used to detect various autoantibodies. The CSF test for the presence of antibodies is important because it is more sensitive and reflects disease activity in many autoimmune encephalitis, although antibody tests can be negative even in the presence of autoimmune encephalitis. EEG is often abnormal, but nonspecific. A unilateral or bilateral medial temporal T2 high signal is a common finding in MRI. Fludeoxyglucose-positron emission tomography is sometimes useful for diagnosis in patients with normal MRI.
Fast Approximation Algorithms for Fractional Packing and Covering Problems (1995)

This paper presents fast algorithms that find approximate solutions for a general class of problems, which we call fractional packing and covering problems. The only previously known algorithms for solving these problems are based on general linear programming techniques. The techniques developed in this paper greatly outperform the general methods in many applications, and are extensions of a method previously applied to find approximate solutions to multicommodity flow problems. Our algorithm is a Lagrangian relaxation technique; an important aspect of our results is that we obtain a theoretical analysis of the running time of a Lagrangian relaxation-based algorithm. We give several applications of our algorithms. The new approach yields several orders of magnitude of improvement over the best previously known running times for algorithms for the scheduling of unrelated parallel machines in both the preemptive and the nonpreemptive models, for the job shop problem, for the Held and Karp bound for the traveling salesman problem, for the cutting-stock problem, for the network embedding problem, and for the minimum-cost multicommodity flow problem.
Absolute photoabsorption measurements of Mg, Al, and Si in the soft-x-ray region below the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="italic">L</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn><mml:mo>,</mml:mo><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>edges (1994)

Absolute measurements of the photoabsorption coefficient of Mg, Al, and Si from 25 eV up to the ${\mathit{L}}_{3}$ absorption edge are presented. Transmission measurements were performed on free-standing thin films using a laser-produced plasma source. The surface oxide is corrected for by taking the ratio of the absorption for different film thicknesses. The values so obtained are, in general, lower than have been reported in the literature. Structure below the edge is observed for Al and Si. Despite the fact that the absorption below the ${\mathit{L}}_{3}$ edge is due to the valence or conduction electrons, the magnitude of the absorption coefficient for the solid is much higher than is predicted by a simple Drude model and is close to that expected from calculations for the free atom.
Temperature dependence of the conductance and magnetoresistance of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi mathvariant="normal">Cr</mml:mi><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>powder compacts (2001)

${\mathrm{CrO}}_{2}$ cold-pressed powder compacts show different electronic transport property than the single crystals. We have analyzed the temperature dependence of the conductance and magnetoresistance (MR) of cold-pressed compacts of ${\mathrm{CrO}}_{2}$ powders. Our results show that there exist two channels of the conductance $G.$ One is the inter-granular spin-dependent tunneling conductance ${(G}_{\mathrm{SDT}}),$ which is found proportional to $\mathrm{exp}(\ensuremath{-}{1/T}^{1/2}).$ The other is a spin-independent channel ${(G}_{\mathrm{SI}})$ due to the higher-order inelastic hopping through the localized states due to imperfections in the barrier. ${G}_{\mathrm{SI}}$ is found to follow the power law ${T}^{\ensuremath{\gamma}}$ and \ensuremath{\gamma} is related to the number of localized states in the barrier. At low temperatures the conductance is determined essentially by the SDT channel. As the temperature increases, the hopping channel becomes dominant. This spin-independent inelastic hopping conductance is one of the main reasons for the rapid decrease of MR with increasing temperature.
Grain growth and size distribution in ion-irradiated chemical vapor deposited amorphous silicon (1989)

The amorphous to polycrystal transition in chemical vapor deposited (CVD) amorphous silicon has been studied at 450 °C under Kr ion beam irradiation. The average grain size increases linearly with the ion dose, and the grain size distribution is very narrow compared to thermally grown grains. These results are consistent with the presence of crystal seeds in CVD material. All these seeds can grow simultaneously under ion beam irradiation. For layers completely preamorphized by Ge+ implantation, no ion beam induced nucleation is observed.