gebhart/patrepeval huggingface dataset:
Ankyrin Repeat Domain 1, <i>ANKRD1</i>, a Novel Determinant of Cisplatin Sensitivity Expressed in Ovarian Cancer (2008)

These findings suggest that ANKRD1, a gene not previously associated with ovarian cancer or with response to chemotherapy, is associated with treatment outcome, and decreasing ANKRD1 expression, or function, is a potential strategy to sensitize tumors to platinum-based drugs.
Positive Selection Through a Motif in the αβ T Cell Receptor (1998)

The two lineages of T cells, alphabeta and gammadelta, differ in their developmental requirements: only alphabeta T cells require major histocompatibility complex recognition, a process known as positive selection. The alphabeta T cell receptor (TCR), but not its gammadelta counterpart, contains a motif within the alpha-chain connecting peptide domain (alpha-CPM) that has been conserved over the last 500 million years. In transgenic mice expressing an alphabeta TCR lacking the alpha-CPM, thymocytes were blocked in positive selection but could undergo negative selection. Thus, the alpha-CPM seems to participate in the generation of signals required for positive selection.
Utility of a physiologically–based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug–drug–disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice (2012)

These simulations suggest that a drug-drug-disease interaction is possible, which may significantly increase rivaroxaban exposure and increase bleeding risk. These simulations render more mechanistic insights as to the possible outcomes and allow one to reach a decision to add cautionary language to the approved product labeling for rivaroxaban.
Band line-up transition in Al<i>x</i>Ga1−<i>x</i>As/In0.5Ga0.5P from capacitance-voltage analysis (1996)

The conduction-band discontinuity ΔEc of AlxGa1−xAs/In0.5Ga0.5P heterojunctions grown by liquid phase epitaxy on GaAs substrate was studied using the capacitance–voltage (C–V) characterization technique. The C–V measurements were made on a series of samples with x ranging from zero to about 0.3. The carrier profiles for the samples with x=0 and x=0.06 give ΔEc values of 90 and 40 meV, respectively, showing the type I (straddling) band line-up. For x=0.18 and 0.29, the values of ΔEc were 45 and 110 meV, respectively, with the carrier profile characteristic of the type II (staggered) band line-up. From these results, ΔEc of the heterojunction is found to vanish at about x = 0.12. This agrees well with our previous result determined from the photoluminescence measurements.
Resonant and off-resonant two-color Raman solitons in gas filled photonic band-gap fibres (2005)

We report numerical investigation of propagation of two-color temporal solitons supported by Raman nonlinearity in the gas filled hollow-core photonic crystal fibres. We investigate solitons tuned close to and detuned far from the Raman resonance.
Commercial Buck Converters and Custom Coil Development for the Atlas Inner Detector Upgrade (2010)

A new generation of higher gain commercial buck converters built using advanced short channel CMOS processes has the potential to operate in the Atlas Inner Detector at the Super Large Hadron Collider (sLHC). This approach would inherently be more efficient than the existing practice of locating the power conversion external to the detector. The converters must operate in a large magnetic field and be able to survive both high doses of ionizing radiation and large neutron fluences. The presence of a large magnetic field necessitates the use of an air core inductor which is developed and discussed here. Noise measurements will be made to investigate the effect of the high frequency switching of the buck converter on the sensitive front end electronics. Radiation hardness of selected buck converters and mosfets will also be reported.
Rhizoferrin: A complexone type siderophore of the mocorales and entomophthorales (Zygomycetes) (1992)

The present investigation presents evidence that rhizoferrin, a novel polycarboxylate or complexone-type siderophore, originally isolated from Rhizopus microsporus, represents the common siderophore within the Zygomycetes. Thus, rhizoferrin could be detected by HPLC analysis in various families of the Mucorales, e.g., Rhizopus microsporus var. rhizopodiformis, Mucor mucedo and Phycomyces nitens (Mucoraceae), Chaetostylum fresenii and Cokeromyces recurvatus (Thamnidiaceae), Cunninghamella elegans and Mycotypha africana (Choanephoraceae) and Mortierella vinacea (Mortierellaceae) and in Basidiobolus microsporus (Entomophthorales). The function of rhizoferrin as a siderophore in the fungus R. microsporus var. rhizopodiformis was demonstrated by time- and concentration-dependent uptake of [55Fe]-labelled rhizoferrin, yielding saturation kinetics with values of Km= 8 μM and Vmax= 1.2 nmol min−1 (mg dry wt)−1.
Distinct protein tyrosine phosphorylation during mitogenesis induced in quiescent sv40‐transformed 3T3 T cells by insulin or vanadate (1994)

Insulin and vanadate selectively induce mitogenesis in quiescent SV40 large T antigen-transformed 3T3 T cells (CSV3-1) but not in quiescent nontransformed 3T3 T cells. Insulin and vanadate mediate this effect in CSV3-1 cells by distinct signal transduction mechanisms that involve protein tyrosine kinase activity. To further study these processes, changes in protein tyrosine phosphorylation induced by insulin and vanadate were investigated. Using immunoprecipitation and Western blotting techniques with antiphosphotyrosine antibodies, we report distinct protein phosphorylation characteristics in insulin- and vanadate-stimulated CSV3-1 cells. The insulin receptor beta-subunit is phosphorylated within 2 min after insulin stimulation of transformed CSV3-1 cells. Insulin also stimulates a rapid increase in tyrosine phosphorylation of the 170 kDa insulin receptor substrate-1 and complex formation between the phosphorylated insulin receptor substrate-1 and the 85 kDa subunit of phosphatidylinositol 3'-kinase. In contrast, vanadate does not initially increase detectable phosphorylation of any proteins, including neither the insulin receptor nor the insulin receptor substrate-1. After 60 min, however, a marked increase in tyrosine phosphorylation of 55 and 64 kDa proteins is observed in vanadate-treated CSV3-1 cells. Furthermore, treatment of CSV3-1 cells with genistein abolishes the effects of vanadate on protein tyrosine phosphorylation but only minimally inhibits the effects of insulin. Finally, insulin stimulates the phosphorylation of a 33 kDa protein, whereas vanadate does not. By comparison, in nontransformed 3T3 T cells, insulin induces a delayed and weaker tyrosine phosphorylation of the insulin receptor beta-subunit and vanadate does not enhance the tyrosine phosphorylation of the 55 and 64 kDa proteins. These data together indicate that the mitogenic effects of insulin and vanadate are associated with distinct protein phosphorylation patterns that appear to be differentially regulated in SV40-transformed and nontransformed 3T3 T cells.
A skill-based system for object perception and manipulation for automating kitting tasks (2015)

The automation of kitting tasks-collecting a set of parts for one particular car into a kit-has a huge impact in the automotive industry. It considerably increases the automation levels of tasks typically conducted by human workers. Collecting the parts involves picking up objects from pallets and bins as well as placing them in the respective compartments of the kitting box. In this paper, we present a complete system for automated kitting with a mobile manipulator thereby focusing on depalletizing tasks and placing. In order to allow for low cycle times, we present particularly efficient solutions to object perception as well as motion planning and execution. For easy portability to different platforms, all components are integrated into a skill-based framework that is tightly coupled with a task planning component. We present results of experiments at both a research laboratory environment and at the industrial site of PSA Peugeot Citroën serving as a proof of concept for the overall system design and implementation.
Gastric mucosal histamine, histamine formation capacity (HFC) and plasma gastrin after cysteamine administration. (1984)

Cysteamine administration is followed by stomach and duodenal ulcers in rats. We aimed to establish a time relationship between changes in gastric mucosal histamine, histamine formation capacity (HFC) and plasma gastrin after cysteamine administration. Up to 4 h after cysteamine s.c., no ulcers were found. Plasma gastrin rose after cysteamine and was higher than in controls 2h after injection. Mucosal histamine fell after 4h; no other significant changes were found in mucosal histamine and HFC. A direct correlation was found between plasma gastrin and HFC in both controls and after cysteamine. It is suggested that the changes indicate that cysteamine releases gastrin, which increases HFC and thus histamine. The fall in histamine seems to indicate utilization of histamine in acid production.
DNA Polymorphisms in the <i>pepA</i> and PPE18 Genes among Clinical Strains of <i>Mycobacterium tuberculosis</i> : Implications for Vaccine Efficacy (2007)

Tuberculosis continues to be a leading cause of death worldwide. Development of an effective vaccine against Mycobacterium tuberculosis is necessary to reduce the global burden of this disease. Mtb72F, consisting of the protein products of the pepA and PPE18 genes, is the first subunit tuberculosis vaccine to undergo phase I clinical trials. To obtain insight into the ability of Mtb72F to induce an immune response capable of recognizing different strains of M. tuberculosis, we investigated the genomic diversity of the pepA and PPE18 genes among 225 clinical strains of M. tuberculosis from two different geographical locations, Arkansas and Turkey, representing a broad range of genotypes of M. tuberculosis. A combination of single nucleotide polymorphisms (SNPs) and insertion/deletions resulting in amino acid changes in the PPE18 protein occurred in 47 (20.9%) of the 225 study strains, whereas SNPs resulted in amino acid changes in the PepA protein in 14 (6.2%) of the 225 study strains. Of the 122 Arkansas study strains and the 103 Turkey study strains, 32 (26.2%) and 15 (14.6%), respectively, had at least one genetic change leading to an alteration of the amino acid sequence of the PPE18 protein, and many of the changes occurred in regions previously reported to be potential T-cell epitopes. Thus, immunity induced by Mtb72F may not recognize a proportion of M. tuberculosis clinical strains.
Diabetic foot infections: current concept review (2012)

The purpose of this manuscript is to provide a current concept review on the diagnosis and management of diabetic foot infections which are among the most serious and frequent complications encountered in patients with diabetes mellitus. A literature review on diabetic foot infections with emphasis on pathophysiology, identifiable risk factors, evaluation including physical examination, laboratory values, treatment strategies and assessing the severity of infection has been performed in detail. Diabetic foot infections are associated with high morbidity and risk factors for failure of treatment and classification systems are also described. Most diabetic foot infections begin with a wound and once an infection occurs, the risk of hospitalization and amputation increases dramatically. Early identification of infection and prompt treatment may optimize the patient's outcome and provide limb salvage.
Smooth Muscle Relaxants (1985)

The term smooth muscle relaxant encompasses a broad spectrum of agents that relax both vascular and non vascular smooth muscle. Therapeutically these relaxants are used for the treatment of bronchospastic disorders, premature labor, and a variety of cardiovascular disorders (e.g., hypertension, angina pectoris, peripheral vascular disease, arrhythmias, and congestive heart failure). A few of the relaxants have proven to be useful tools for investigational purposes, for example, xanthines (phosphodiesterase inhibition and the role of cyclic 3′,5′-monophosphate in mediating cellular events) and calcium-channel blockers (elucidating the role of calcium in normal cell function and drug action). This chapter attempts to discuss current pharmacodynamics, pharmacokinetics, and clinical pharmacology of smooth muscle relaxants and to give the researcher, clinician, graduate and medical student basic information on these compounds.KeywordsVascular Smooth MuscleSodium NitroprussideSmooth Muscle RelaxantIsosorbide DinitratePeak Plasma LevelThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Rich-Media Tags: Battery-free wireless multichannel digital audio and image transmission with UHF RFID techniques (2013)

In this paper we present the first fully passive (battery-free) wireless transmission of multiple digital audio channels and images via modulated backscatter. We leverage a previously reported single chip, passive transponder that can digitize and uplink up to 10 analog input channels sampled at a rate of 26.1 kHz. Given a base station transceiver operating at a frequency of 915 MHz and a transmit power of +36 dBm EIRP, the transponder has a demonstrated operating range of ≈1.4 m. The transponder data uplink uses binary phase-shift key (BPSK) modulated backscatter operating at a total link throughput rate of 5 Mbps, with an uplink energy consumption of only 3.7 pJ/bit. The transponder was initially designed for biomedical telemetry of neural and EMG signals. We present a new application of this tag for multichannel, high fidelity digital audio recording, as well as color image transfer using a slow-scan television (SSTV) modulation (PD290) with a resolution of 640 by 493 pixels. Additionally, we demonstrate fully-passive digital recording of ambient sound using a microphone powered by the chip's harvested energy at an operating range of 0.72 m. The passive, digital microphone is sensitive enough to record human speech within approximately 5 m of the device. We believe these results will serve as a first step toward media-rich battery-free (wirelessly powered) devices that take advantage of the high speed, low power nature of modulated backscatter communication links.
Unobtrusive measurement of daily computer use to detect mild cognitive impairment (2013)

Computer use change can be monitored unobtrusively and indicates individuals with MCI. With 79% of those 55 to 64 years old now online, this may be an ecologically valid and efficient approach to track subtle, clinically meaningful change with aging.
Observation of mode selection in a radially anisotropic cylindrical waveguide with liquid-crystal cladding (1994)

Observation of mode selection in an optical fiber with nematic liquid-crystal cladding is reported. The TE01 mode is guided, while the TM01 mode leaks out. This behavior is achieved by radially oriented liquid-crystal directors in the cladding of an optical fiber with isotropic core. A theory which quantitatively accounts for the results is given.
Modification of arginine in proteins by oligomers of 2,3-butanedione (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModification of arginine in proteins by oligomers of 2,3-butanedioneJohn A. Yankeelov, Jr.Cite this: Biochemistry 1970, 9, 12, 2433–2439Publication Date (Print):June 9, 1970Publication History Published online1 May 2002Published inissue 9 June 1970https://pubs.acs.org/doi/10.1021/bi00814a007https://doi.org/10.1021/bi00814a007research-articleACS PublicationsRequest reuse permissionsArticle Views372Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modulation of gene expression by drugs affecting deoxyribonucleic acid gyrase (1979)

Nalidixic acid (Nal), a drug which affects deoxyribonucleic acid gyrase activity, inhibits the expression of catabolite-sensitive genes: the three maltose operons, the lactose and galactose operons, and the tryptophanase gene. A correlation between the degree of sensitivity to Nal and that to catabolite repression has been observed. The expression of the threonine and tryptophan operons, insensitive to catabolite repression, is insensitive to Nal. The expression of the lacZ gene under the control of the IQ promoter is activated by Nal. Strains carrying a mutation in the nalA locus are resistant to these effects. Novobiocin, which inhibits the negative supercoiling activity of deoxyribonucleic acid gyrase, affects expression of the operons similarly to Nal. The involvement of promoters in Nal and novobiocin action, as well as a possible role of in vivo negative supercoiling in the selectivity of gene expression, are discussed.
Integration of seismic and well-log data using statistical and neural network methods (2017)

In the last two to three decades, the use of seismic attributes for reservoir characterization and modeling has grown exponentially. Now, a dozen or more attributes are often extracted from seismic data to predict reservoir properties. Meanwhile, an increasing trend of acquiring more wireline logs provides more and more data to describe reservoir properties. Both statistical methods and artificial neural networks (ANNs) are often used to extract information and make predictions. Although statistical methods and ANNs provide powerful tools for geoscience data integration, they also have pitfalls. We present principal component analysis (PCA) and ANNs for facies classifications and porosity prediction. We also show the use and limitations of these methods and the importance of integrating the geologic and petrophysical knowledge.
TP53 and progression from Barrett’s metaplasia to oesophageal adenocarcinoma in a UK population cohort (2006)

Immunohistochemical detection of TP53 expression is a biomarker of malignant progression in Barrett's oesophagus but sensitivity is too low to act as a criterion to inform endoscopic surveillance strategies. Additional biomarkers are required which when combined with TP53 will identify, with adequate sensitivity and specificity, Barrett's patients who are at risk of developing cancer.
Kinetics of 18-Carbon Carboxylate Adsorption at the Fluorite Surface (1997)

In this study the kinetics of oleate and linoleate adsorption at the fluorite surface have been examined, in-situ, by Fourier transform infrared internal reflection spectroscopy. Data obtained in this study show that the adsorption process is not controlled by convective diffusion. Other results from this study indicate that oleate adsorbs to approximately the same monolayer coverage level when given sufficient time over a variety of temperature and solution conditions. This study also shows that competitive anions such as OH-, CO32-, and F- can severely restrict the rate of oleate adsorption; furthermore, proper control of such species will result in maximum oleate adsorption kinetics.
A Comparative Efficacy and Safety Study of Long-Acting Risperidone Injection and Risperidone Oral Tablets Among Hospitalized Patients: 12-Week Randomized, Single-Blind Study (2006)

The results indicated that with optimal controlling of drug compliance among hospitalized patients, RLAI showed no benefit of efficacy over oral risperidone, but with advantages of improved side-effect profiles, social life ratings, and reduced prolactin levels.
BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain (2012)

The bromodomain protein, BRD4, has been identified recently as a therapeutic target in acute myeloid leukemia, multiple myeloma, Burkitt's lymphoma, NUT midline carcinoma, colon cancer, and inflammatory disease; its loss is a prognostic signature for metastatic breast cancer. BRD4 also contributes to regulation of both cell cycle and transcription of oncogenes, HIV, and human papilloma virus (HPV). Despite its role in a broad range of biological processes, the precise molecular mechanism of BRD4 function remains unknown. We report that BRD4 is an atypical kinase that binds to the carboxyl-terminal domain (CTD) of RNA polymerase II and directly phosphorylates its serine 2 (Ser2) sites both in vitro and in vivo under conditions where other CTD kinases are inactive. Phosphorylation of the CTD Ser2 is inhibited in vivo by a BRD4 inhibitor that blocks its binding to chromatin. Our finding that BRD4 is an RNA polymerase II CTD Ser2 kinase implicates it as a regulator of eukaryotic transcription.
Analysis of 20 pregnant women complicated with malignant ovarian tumor (2010)

Objective To investigate the clinical characteristics, management and prognosis of ovarian malignant tumor in pregnancy. Methods A retrospective analysis was conducted on the clinical data of 20 women with ovarian malignancies during pregnancy between July 2001 and December 2008. Results The incidence of ovarian malignant tumor in pregnancy was 0. 311/1000 deliveries in the past 8 years and 14 (70.0%) were diagnosed through ultrasound during the index pregnancy. Most of the pathological results were ovarian epithelial tumors (n= 15,75. 0%). Fourteen (70. 0%) were diagnosed as low grade malignant tumors (including epithelial borderline tumor and sertoli-leydig cell tumor). Nineteen (95. 0%) of the patients were diagnosed in stage I (FIGO). Sixteen (80. 0%) were treated by conservative operation, and second ovarian carcinomectomy were performed for four (20. 0%) women. Chemotherapy was administered to 30. 0% (6 cases) of the patients, one of which during pregnancy. Totally, 15 neonates were born. One premature newborn died from severe asphyxia, and the rest 4 preterm and 10 full term babies are healthy. The tumor free survival rate of these 20 women was 95.0% (19 cases) during a follow-up of 6-80 months. Conclusions Ovarian carcinoma has a lower incidence during pregnancy and mostly are in early stage. Proper treatment may ensure a better maternal and fetal outcomes.

Key words: 
Pregnancy complications, neoplastic;  Ovarian neoplasms;  Prognosis