gebhart/patrepeval huggingface dataset:
Synthesis and Characterization of a Blue Light Emitting Polymer Containing Both Hole and Electron Transporting Units (1999)

A luminescent bipolar polymer 7, consisting of a Ar3N−stilbene moiety and an oxadiazole moiety, has been synthesized. A smooth and dense thin film of polymer 7 is easily obtained by spin-coating from its chloroform solution. This film exhibits a strong fluorescence in the blue. More importantly, polymer 7 possesses an extremely high thermal stability with a 5% weight loss temperature of 480 °C under nitrogen, and a relatively high glass transition temperature (Tg) of 239 °C. Single-layer EL devices fabricated with this polymer emitted low intensity blue light after a turn-on voltage of 5 V. The brightness, luminance, and apparent quantum efficiency of these devices are drastically improved by adding, between polymer 7 and the Al cathode, another spin-coated polymer layer containing an oxadiazole derivative.
Genetic relationship between the 53- and 49-kilodalton forms of exoenzyme S from Pseudomonas aeruginosa (1996)

Exoenzyme S is an ADP-ribosylating extracellular protein of Pseudomonas aeruginosa that is produced as two immunologically related forms, a 49-kDa enzymatically active form and a 53-kDa inactive form. The postulated relationship between the two proteins involves a carboxy-terminal proteolytic cleavage of the 53-kDa precursor to produce an enzymatically active 49-kDa protein. To determine the genetic relationship between the two forms of exoenzyme S, exoS (encoding the 49-kDa form) was used as a probe in Southern blot analyses of P. aeruginosa chromosomal digests. Cross-hybridizing bands were detected in chromosomal digests of a strain of P. aeruginosa in which exoS had been deleted by allelic exchange. A chromosomal bank was prepared from the exoS deletion strain, 388deltaexoS::TC, and screened with a probe internal to exoS. Thirteen clones that cross-hybridized with the exoS probe were identified. One representative clone contained the open reading frame exoT; this open reading frame encoded a protein of 457 amino acids which showed 75% amino acid identity to ExoS. The exoT open reading frame, cloned into a T7 expression system, produced a 53-kDa protein in Escherichia coli, termed Exo53, which reacted to antisera against exoenzyme S. A histidine-tagged derivative of recombinant Exo53 possessed approximately 0.2% of the ADP-ribosyltransferase activity of recombinant ExoS. Inactivation of exoT in an allelic-replacement strain resulted in an Exo53-deficient phenotype without modifying the expression of ExoS. These studies prove that the 53- and 49-kDa forms of exoenzyme S are encoded by separate genes. In addition, this is the first report of the factor-activating-exoenzyme-S-dependent ADP-ribosyltransferase activity of the 53-kDa form of exoenzyme S.
A high-speed, programmable, CSD coefficient FIR filter (2002)

A new high-speed, programmable FIR filter is present, which is a multiplierless filter with CSD encoding coefficients. With this encoding scheme, the speed of filter is improved and the area is optimized. In order to make this filter more applicable, we employ a new programmable CSD encoding structure to make CSD coefficients programmable. In the end of this paper, we design a 10-bits, 18 taps video luminance filter with the filter structure we present. The completed filter core occupies 6.8/spl times/6.8 mmm/sup 2/ of silicon area in Wu-Xi Shanghua 0.6 /spl mu/m 2P2M CMOS technology, and its maximum work frequency is 100 MHz.
CEP‐1347/KT‐7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Aβ‐induced cortical neuron apoptosis (2001)

Although the mechanism of neuronal death in Alzheimer's disease (AD) has yet to be elucidated, a putative role for c-jun in this process has emerged. Thus, it was of interest to delineate signal transduction pathway(s) which regulate the transcriptional activity of c-jun, and relate these to alternate gene inductions and biochemical processes associated with beta-amyloid (Abeta) treatment. In this regard, the survival promoting activity of CEP-1347, an inhibitor of the stress-activated/c-jun N-terminal (SAPK/JNK) kinase pathway, was evaluated against Abeta-induced cortical neuron death in vitro. Moreover, CEP-1347 was used as a pharmacologic probe to associate multiple biochemical events with Abeta-induced activation of the SAPK/JNK pathway. CEP-1347 promoted survival and blocked Abeta-induced activation of JNK kinase (MKK4, also known as MEK-4, JNKK and SEK1) as well as other downstream events associated with JNK pathway activation. CEP-1347 also blocked Abeta-induction of cyclin D1 and DP5 genes and blocked Abeta-induced increases in cytoplasmic cytochrome c, caspase 3-like activity and calpain activation. The critical time window for cell death blockade by CEP-1347 resided within the peak of Abeta-induced MKK4 activation, thus defining this point as the most upstream event correlated to its survival-promoting activity. Together, these data link the SAPK/JNK pathway and multiple biochemical events associated with Abeta-induced neuronal death and further delineate the point of CEP-1347 interception within this signal transduction cascade.
Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes (2007)

Mutations in MECP2 cause the autism-spectrum disorder Rett syndrome. MeCP2 is predicted to bind to methylated promoters and silence transcription. However, the first large-scale mapping of neuronal MeCP2-binding sites on 26.3 Mb of imprinted and nonimprinted loci revealed that 59% of MeCP2-binding sites are outside of genes and that only 6% are in CpG islands. Integrated genome-wide promoter analysis of MeCP2 binding, CpG methylation, and gene expression revealed that 63% of MeCP2-bound promoters are actively expressed and that only 6% are highly methylated. These results indicate that the primary function of MeCP2 is not the silencing of methylated promoters.
Pathological heterogeneity in progressive supranuclear palsy and corticobasal degeneration (2004)

Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are sporadic neurodegenerative disorders of late adult life. Focal asymmetric cortical atrophy with ballooned neurons, nigral degeneration, and tau-positive neuronal and glial lesions in both the gray and white matter, especially astrocytic plaques in the affected cerebral cortex, are characteristic features of CBD. While cortical involvement may occur in PSP, ballooned neurons are sparse and limited to the limbic system, and tufted astrocytes are abundant in the precentral gyrus and striatum. The present findings suggest that PSP and CBD are distinct pathological entities. However, there exist 'atypical' cases of PSP and CBD. Severe cortical involvement or asymmetric cortical atrophy can be seen in PSP. Ballooned neurons are sparse or difficult to detect in some cases of CBD, in spite of typical cortical tau pathology. Cortical symptoms are absent or only mild in 'minimal change' CBD. Moreover, several neurodegenerative disorders can underlie CBD. This pathological heterogeneity leads to difficulty in the clinical and pathological diagnosis of both disorders.
Sequence, expression, and function of the gene for the nonphosphorylating, NADP-dependent glyceraldehyde-3-phosphate dehydrogenase of Streptococcus mutans (1995)

We report the sequencing of a 2,019-bp region of the Streptococcus mutans NG5 genome which contains a 1,428-bp open reading frame (ORF) whose putative translation product had 50% identity to the amino acid sequences of the nonphosphorylating, NADP-dependent glyceraldehyde-3-phosphate dehydrogenases (GAPN) from maize and pea. This ORF is located approximately 200 bp downstream of the ptsI gene coding for enzyme I of the phosphoenolpyruvate:sugar phosphotransferase transport system. Mutant BCH150, in which the putative gapN gene had been inactivated, lacked GAPN activity that was present in the wild-type strain, thus positively identifying the ORF as the S. mutans gapN gene. Another strain of S. mutans, DC10, which contains an insertionally inactivated ptsI gene, still possessed GAPN activity, as did S. salivarius ATCC 25975, which contains an insertion element between the ptsI and gapN genes. Since the wild-type S. mutans NG5 lacks both glucose-6-phosphate dehydrogenase and NADH:NADP oxidoreductase activities, the NADP-dependent glyceraldehyde-3-phosphate dehydrogenase is important as a means of generating NADPH for biosynthetic reactions.
Risperidone in the Treatment of Disorders with a combined Psychotic and Depressive Syndrome - A Functional Approach (1992)

In vitro receptor-binding profiles and in vivo pharmacological studies have shown risperidone to be a potent mixed serotonin-S2 dopamine-D2-like receptor antagonist. While anti-D2 activity may relate to the antipsychotic potency of neuroleptic drugs, an antidepressive efficacy of substances with anti-S2 activity has been suggested. In an open pilot-study, ten patients with schizodepressive disorders or a DSM-III-R diagnosis of psychotic major depressive episodes were treated with risperidone (2-10 mg/d) for six weeks. Weekly psychopathological evaluation was performed, including BPRS, SANS, SAPS, VAS scales, and AIMS and UKU for the assessment of side-effects. Generally, the psychotic syndrome (BPRS, SANS and SAPS) decreased markedly in all patients; seven patients also showed a clinically significant improvement of depressive symptoms (BPRS). Except for two patients who needed biperiden because of extrapyramidal side-effects, the tolerance of risperidone was good. The antipsychotic and antidepressive properties of risperidone shown in our pilot study are promising enough to merit full double-blind controlled trials for further evaluation of its therapeutic value in this broad spectrum of psychiatric disorders.
Foldable Containers: a New Perspective on Reducing Container-Repositioning Costs (2001)

There is little doubt that the requirement to reposition empty containers is one of the more persistent problems in the container transport industry, and is a key factor in cutting operating costs. Empty container transport involves high costs, particularly for shipping lines, since they generally bear these container management costs. Not surprisingly, shipping lines try to reduce the costs of moving empty containers as much as they can. Most strategies are focussed on improving the instruments to match cargo with empty containers. However, due to trade imbalances transport movements of empty containers remain to some extent unavoidable. Therefore, foldable containers seem an attractive option from the point of view of saving transport costs as well as handling and storage costs. So far, however, these containers have not been introduced successfully. In this paper we analyse why previous initiatives for foldable containers failed and discuss the conditions required for successful commercial applications. Although the economic advantages of foldable containers seem evident, we explain that these types of boxes have to cope with scepticism about technical performance, the complexity of the folding and unfolding process in particular, as well as logistical and organisational problems with using foldable containers.
Investigation of advanced thermal-chemical concepts for obtaining improved MSW-derived products. Final report. [MSW = municipal wastes] (1978)

Although a number of resource recovery from refuse programs have been effective, the quality of the products recovered could be enhanced to improve their marketability. The purpose of this study was to investigate the potential of known processes that could improve the quality of the fuels or other products derived from the organic fraction in refuse. Possible processes for improving the quality of products from the organic fraction derived from municipal solid waste (MSW) were determined, and descriptions were developed for each process. An analytical framework for technical and economic assessment was developed to serve as a guide for analysis. Major thermal and chemical processes used in the pulp and paper, wood, textile, and resource recovery industries were identified. This study concentrated on those processes designed to produce a carbon char, a powdered fuel, and liquid and gaseous fuels from the municipal solid waste. The chemical and thermal treatments of most interest were the Worcester Polytechnic's hydrogenation-liquefaction process, Wright-Malta's steam injection pyrolysis process, and cellulose embrittlement. Basic requirements were defined for producing a fine powdered fuel from the organic faction of MSW. More quantitative measurements of the embrittlement process parameters are recomended.
A gateway-based solution for remote accessing to residential UPnP services networks (2010)

Home networks comprise very heterogeneous devices interconnected through the residential gateway. They deploy complex services networks within the home environment using technologies such as Universal Plug and Play (UPnP). This technology provides the home network clients with a standard for device auto-discovery and transparent interoperability. However, the UPnP standard has an important constraint. It is designed to be used in local networks, so it is not suitable for service sharing among home networks. This article solves this limitation proposing a small footprint, low latency and non intrusive solution, capable of deploying a common UPnP services network between several residential environments. The proposed system consists of a software module installable over OSGi-based gateways, which applies identity theft and NAT techniques to allow the interoperation between UPnP devices from different subnets. It is based on SIP and UPnP IGD technologies, as well as on an extension of the UPnP standard fully described in this article. As a result, a prototype has been implemented, in order to check the successful operation of the complete system.
Iontophoresis of gentamicin into aphakic rabbit eyes. Sustained vitreal levels. (1984)

The authors evaluated the intraocular penetration of gentamicin (50 mg/ml) into aphakic rabbit eyes following anodal iontophoresis (0.75 mA for 10 min). Gentamicin levels were determined at 0.5, 4, 8, 16, and 24 hrs after iontophoresis (n = 6 eyes for each time) using an agar diffusion bioassay. Peak levels of 72.04 +/- 6.1 (means +/- SE) micrograms/ml for the corneas and 77.8 +/- 3.0 micrograms/ml for the aqueous humor were obtained at 30 min after iontophoresis. The peak vitreous level was 10.4 +/- 0.4 micrograms/ml, which was found at 16 hrs after iontophoresis. Therapeutic levels of 6.2 +/- 3.0 micrograms/ml were still present in the vitreous humor 24 hrs after iontophoresis. Iontophoresis appears to be an effective noninvasive method for delivering therapeutic levels of gentamicin into ocular tissues and fluids of the aphakic rabbit eye.
General score tests for associations of genetic markers with disease using cases and their parents (1996)

Association studies of genetic markers with disease play a critical role in the dissection of genetically complex traits because they are relatively easy to conduct and are useful for fine-scale mapping of genetic traits. The advantage of family-based controls has recently received much attention because spurious associations caused by population structure can be controlled for, and marker genotype information on diseased cases and their parents can be used to test the compound hypothesis of both linkage and linkage disequilibrium. However, debate still exists regarding the statistical methods of analysis. Herein are presented statistical methods to test for linkage (in the presence of linkage disequilibrium) between multiallelic genetic markers and disease when diseased subjects (cases) and their parents are sampled. Theoretical considerations for the development of general statistical tests are presented as well as asymptotic formulas to compute their power when planning a study. Furthermore, simulation results for nine specific statistics are used to contrast the power of these methods under different genetic mechanisms leading to disease (dominant vs. recessive, one vs. two high-risk alleles). These results demonstrate substantial gains in power for specific statistical tests designed to detect specified genetic mechanisms. However, without a priori knowledge of the likely genetic mechanism, it is desirable to rely on a fairly robust statistical method, robust so that power is not drastically lost when either dominant or recessive mechanisms are acting, and when either one or more than one marker alleles are associated with disease. Based on both theoretical and simulation results, a general score statistic, which generalizes the transmission/disequilibrium test, tends to offer sufficient power for a variety of genetic mechanisms, so that it is worth considering for broad use in studies which use genetic marker information from both diseased cases and their parents.
To Join the Feminist Blogosphere, Click Here! (2006)

The article discusses the use of Web logging in teaching women's studies in classrooms. Aside from Web logging, the author also integrated message boards and other Web technologies into the teaching process. The use of these technologies afford the students to participate in online dialogues, express themselves freely on the Web and they can be assessed objectively based on their actual insight into various subjects. Most importantly, the use of these technologies effectively connect feminism with students in digital means.
Welcome to Silverlight 2 (2009)

This chapter introduces Silverlight, a Microsoft cross-browser, cross-platform plug-in that allows you to create rich interactive (or Internet) applications (RIAs) for the Web. It begins with a brief look at the evolution of user interfaces, and then provides an overview of Silverlight. You’ll learn how Silverlight fits into RIA solutions, the benefits it brings to developers, and the tools involved in developing Silverlight-enabled applications.KeywordsVisual StudioDesktop ApplicationIntegrate Development EnvironmentClient MachineRich Internet ApplicationThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Temporal correlation in cat striate-cortex neural spike trains (1996)

The authors draw on point-process theory and wavelet analysis to examine the variability and correlation properties of spike trains from single neurons in the cat striate cortex, under conditions of spontaneous and stimulated (driven) firing. It is not possible to infer the long-term correlation properties of a spike train from measures that reset at short times; thus, often-used spike-train measures, such as the interevent-interval histogram (IIH) and post-stimulus time (PST) histogram, cannot serve this purpose. Rather, the authors make use of the event-number histogram (ENH), also called the spike-number or spike-count distribution. This measure affords the experimenter the opportunity of externally controlling the counting time, T, and therefore the duration over which spike correlations can be viewed. A useful and relatively simple gauge of the correlation properties is obtained from the first two moments of the ENH. In particular, the Fano factor (FF), defined as the ratio of the spike-count variance to the spike-count mean: F(T)=var(N)|N, plotted as a function of the counting time, T, serves this purpose quite well. The FF is a special case of the wavelet Fano factor (WFF) implemented using the Haar wavelet basis.
Image processing based indoor localization system (2014)

In this study, image processing based low cost indoor localization system was developed. Image processing algorithm was developed in C programming language and Open CV image processing library. Frames were captured by a USB camera which was designed for operating at 850 nm wave length to eliminate environmental disturbances. A narrow band pass filter was integrated to camera in order to detect retro reflective labels only. Retro reflective labels were placed ceiling of indoor area with pre-determined equal spaced grids. Approximate location of mobile robot was obtained by label identity and exact location of mobile robot was obtained with detected label's position at image coordinate system. Developed system was tested on a mobile robot platform and it was observed that system is operating successfully in real time.
Wideband planar monopole antennas with dual band-notched characteristics (2006)

Wideband planar monopole antennas with dual band-notched characteristics are presented. The proposed antenna consists of a wideband planar monopole antenna and the multiple /spl cup/-, /spl cap/-, and inverted L-shaped slots, producing band-notched characteristics. In order to generate dual band-notched characteristic, we propose nine types of planar monopole antennas, which have two or three /spl cap/ (/spl cup/ or inverted L)-shaped slots in the radiator. This technique is suitable for creating ultra-wideband antenna with narrow frequency notches or for creating multiband antennas.
Plasmonic Sensing of Oncoproteins without Resonance Shift Using 3D Periodic Nanocavity in Nanocup Arrays (2017)

A sensor design and sensing method based on plasmonic–photonic interactions that occur when a nanocavity array is embedded in a 3D tapered nanocup plasmonic substrate are reported. This device enables highly sensitive detection of refractive index changes based on changes to the transmission peak intensity without shift in the resonance wavelength. Unlike conventional plasmonic sensors, there is a consistent and selective change in the transmission intensity at the resonance peak wavelength with no spectral shift. In addition, there are wavelength ranges that show no intensity change, which can be used as reference regions. The fabrication and characterization of the plasmonic nanocavity sensor are described and also advanced biosensing is demonstrated. Simulations are carried out to better understand the plasmon–photonic coupling mechanism. This nanocavity plasmonic sensor design has a limit of detection of 1 ng mL −1 (5 × 10 −12 m ) for the cancer biomarker carcinoembryonic antigen (CEA), which is a significant improvement over current surface plasmon resonance systems, and a dynamic range that is clinically relevant for human CEA levels.
Drug evaluation: rivaroxaban, an oral, direct inhibitor of activated factor X. (2007)

Bayer AG and Ortho-McNeil Pharmaceutical Inc are developing rivaroxaban, an oral Factor Xa inhibitor, for the potential prevention and treatment of thrombosis. In December 2005 and December 2006, phase III trials were initiated for the prevention of venous thromboembolism (VTE) following major orthopedic surgery and in patients with atrial fibrillation, respectively. By January 2007, a phase III trial for the prevention of VTE following total knee replacement surgery had commenced. In November 2006, a phase II trial for the reduction of VTE in patients with acute coronary syndrome was initiated.