gebhart/patrepeval huggingface dataset:
Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis (2005)

Immune mediated heparin induced thrombocytopenia (HIT) is a prothrombotic adverse effect of heparin. However, only a subgroup of patients with HIT develops thromboembolic complications. We aimed to identify risk factors for developing HITassociated thrombosis. We analyzed a registry of patients with clinical suspicion of HIT who tested positive using a sensitive functional assay. Patient information was obtained by a standardized questionnaire. By multivariate analysis the association of age, gender, type of patient population, and magnitude of the platelet count decline with the frequency, type (venous or arterial), and temporal pattern of thrombotic events was assessed. In 408 HIT patients we observed predominance of venous thrombosis (2.4:1), with 40% of patients developing a pulmonary embolism. However, in the subgroup of post-cardiovascular surgery patients there was predominance of arterial thrombosis (1:8.5). The type of arterial thrombosis (limb artery thrombosis > thrombotic stroke > myocardial infarction) was the converse of that observed with typical atherothrombotic clots in non-HIT populations. In 59.8% of patients HIT-related thrombosis manifested either on the same day a platelet count decrease >50% was documented (26.3%) or before the decrease in platelet counts (33.5%). The most important risk factors for thrombosis were orthopedic/trauma surgery and the magnitude of platelet count decrease. HIT-associated thrombosis occurs in a considerable proportion of patients before platelet counts decrease by more than 50%.
Design and Synthesis of<i>bis</i>-carbamate Analogs of Cyclic<i>bis</i>-(3′-5′)-Diguanylic Acid (c-di-GMP) and the Acyclic Dimer PGPG (2008)

The bacterial second messenger cyclic bis-(3'-5')-diguanylic acid (c-di-GMP) regulates diverse Gram-negative bacterial virulence functions. The pathways that control, or are controlled by, c-di-GMP suggest that c-di-GMP signaling systems may encompass potential drug targets. It is presently undetermined, however, whether up- or down-modulation of c-di-GMP signaling would be the desired therapeutic state. We addressed potential drug target validation by synthesizing nonhydrolysable carbamate analogs of both the cyclic dinucleotide and the acyclic (seco) dinucleotide. A molecular docking simulation of the carbamate isostere suggests that this analog is capable of assuming the correct conformation and pose at a c-di-GMP binding site.
<i>In vivo</i> measurement of water diffusion in the human heart (1994)

Existing magnetic resonance methods for diffusion imaging, including echo planar, are ineffective in the beating heart due to motion-induced signal attenuation. To overcome this problem, we used a diffusion-weighted stimulated echo-echo planar magnetic resonance imaging sequence. The two lobes of the diffusion-sensitizing gradient were synchronized to the same point in successive cardiac cycles in order to fix the cardiac position and avoid bulk motion effects. The apparent diffusion coefficients (ADCs) of the interventricular septum in 12 healthy subjects for diffusion gradients along the x-, y-, and z-directions were 1.40 +/- 0.27, 1.48 +/- 0.35, and 1.78 +/- 0.27 x 10(-3) mm2/s. The ADCs of the interventricular septum in a second group of 15 healthy subjects for diffusion gradients along the short axis, horizontal and vertical long axes were 0.92 +/- 0.15, 1.50 +/- 0.15, and 1.10 +/- 0.24 x 10(-3) mm2/s. Because the ADCs were less than the measured values for skeletal muscle and their standard deviations were low, it seems unlikely that bulk motion effects made the dominant contribution to the measured myocardial ADC for the interventricular septum, although motion and/or susceptibility artifacts frequently degraded measurements in the free wall of the left ventricle. Additional evidence that ADC was not predominantly determined by wall motion was obtained in a third group of patients with various cardiac abnormalities, in whom there was only a weak correlation between ADC and ejection fraction.(ABSTRACT TRUNCATED AT 250 WORDS)
Association of the Est1 protein with telomerase activity in yeast. (1996)

The est1 mutant was previously identified because it is defective in telomere maintenance and displays a senescent phenotype. To see if Est1 might be a component of yeast telomerase, we examined immunoprecipitated Est1. The yeast telomerase RNA Tlc1 specifically coprecipitated with Est1. Furthermore, the Est1 immunoprecipitates contained a telomerase-like activity. As expected for yeast telomerase, the activity elongated telomeric primers, it required dGTP and dTTP but not dATP or dCTP, and it was sensitive to RNase A. Further evidence suggesting that the activity was telomerase was obtained from experiments using a TLC1-1 mutant strain, which has a mutant telomerase template containing dG residues. The activity immunoprecipitated from TLC1-1 mutant strains incorporated 32P-labeled dCTP, while activity from TLC1 strains did not. Use of different telomeric primer substrates revealed two distinguishable telomerase-like activities: one was dependent on TLC1, and one was not. The TLC1-independent activity may be due to a second yeast telomerase RNA, or it may be some other kind of activity.
Modulation of Double‐Stranded RNAs <i>in Vivo</i> by RNA Duplex Unwindasea (1992)

The double-stranded RNA (dsRNA) unwinding/modifying activity is a recently discovered cellular activity capable of unwinding or denaturing dsRNAs by modifying multiple adenosine residues to inosines and creating I-U mismatched base-pairings. The biological functions of this activity, which can potentially mutate the coding capacity of messenger RNAs (mRNAs), are presently not known. However, this unwinding/modifying activity is likely to affect the secondary structures, processing, and turn-over of various eukaryotic as well as viral transcripts. Although the activity was originally found and proposed as a cellular factor that interfered with the use of antisense RNA, it now appears more likely that the activity in fact may participate in antisense RNA suppression of target genes, either by altering the coding capacity of the sense mRNAs or by accelerating the degradation of duplex RNAs. Further understanding of this novel enzymatic activity, and thus, in turn, of the metabolism of dsRNAs in vivo, should allow us to derive a better strategy for designing antisense RNA.
Scanning tunneling microscopy studies of structural disorder and steps on Si surfaces (1989)

Scanning tunneling microscopy observations of several forms of disorder on Si surfaces are presented. These include dimer vacancies on Si(001), step bunches associated with a morphological phase transition on vicinal Si(111), and step structure on vicinal Si(001). A recipe for cleaning of Si surfaces to produce a minimum amount of disorder is presented.
Multi-view and pause-view in a Second Life client (2010)

3D virtual worlds provide rich environments for collaborative work and social networking. The design of these spaces is largely confined by the classical time and space properties that we find in our own physical world. In some cases, some non-physical capabilities like teleportation are provided, but in general, most of the limits that we experience physically such as time linearity, gravity, orientation, and single location, are also experienced in these computer-based virtual worlds. In this paper, we review our activities to bend the time and space limits in a 3D virtual world. In particular, we explore extensions that we have made to a Second Life (a 3D virtual world) viewer to bend the time and space barriers from conventional limits. We present two main extensions, namely: multi-view which allows the viewer to monitor multiple locations in the virtual world (allowing a user to observe and switch quickly between multiple virtual locations), and pause-view which allows the user to pause and then continue (possibly in faster than real-time) a meeting stream (sort of like the pausing of a TV program made possible by digital video recorders). Providing faster than real-time playback allows the viewer to catch up (from a pause or late meeting arrival) so that they can, for example, participate in a closing Q&A session. By using Second Life to mold space and time, we are adding new dimensions and possibilities into the Second Life community.
The <i>Arabidopsis</i> Transcription Factor MYB77 Modulates Auxin Signal Transduction (2007)

Auxin is a key plant hormone that regulates plant development, apical dominance, and growth-related tropisms, such as phototropism and gravitropism. In this study, we report a new Arabidopsis thaliana transcription factor, MYB77, that is involved in auxin response. In MYB77 knockout plants, we found that auxin-responsive gene expression was greatly attenuated. Lateral root density in the MYB77 knockout was lower than the wild type at low concentrations of indole-3-acetic acid (IAA) and also under low nutrient conditions. MYB77 interacts with auxin response factors (ARFs) in vitro through the C terminus (domains III and IV) of ARFs and the activation domain of MYB77. A synergistic genetic interaction was demonstrated between MYB77 and ARF7 that resulted in a strong reduction in lateral root numbers. Experiments with protoplasts confirmed that the coexpression of MYB77 and an ARF C terminus enhance reporter gene expression. R2R3 MYB transcription factors have not been previously implicated in regulating the expression of auxin-inducible genes. Also it was previously unknown that ARFs interact with proteins other than those in the Aux/IAA family via conserved domains. The interaction between MYB77 and ARFs defines a new type of combinatorial transcriptional control in plants. This newly defined transcription factor interaction is part of the plant cells' repertoire for modulating response to auxin, thereby controlling lateral root growth and development under changing environmental conditions.
An SRAM-Based Radiation Monitor With Dynamic Voltage Control in 0.18-<inline-formula> <tex-math notation="LaTeX">$\mu$ </tex-math> </inline-formula>m CMOS Technology (2018)

This paper presents a novel radiation monitor that is based on a custom static random access memory (SRAM) application-specified integrated circuit. Its sensitivity is adjustable through its core supply voltage and the radiation monitoring is based on the upset rate that is measured during a measurement interval in the memory. The sensor has different supply voltages for the SRAM core and the interface logic to prevent incorrect digital signals during the measurement cycle. The memory was processed in a 0.18-μm CMOS technology and was tested with heavy ions with an linear energy transfer from 1.8-60 MeV · cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /mg, 24-GeV protons, and a mixed radiation field. The memory cells were also verified with a two-photon absorption laser. Furthermore, an analysis was made on single-event upsets and multibit upsets.
Nuclear spectroscopy of astrophysical sources (1988)

These proceedings contain papers on the following topics: gamma radiation from supernovae, the galactic plane and center, and the sun; gamma ray bursts; discrete sources; future and proposed satellite experiments; balloon experiments; and instrumentation. Separate abstracts have been prepared for each contribution.
Thyrotropin (TSH) interacts with multiple discrete regions of the TSH receptor: polyclonal rabbit antibodies to one or more of these regions can inhibit TSH binding and function (1994)

As a means of identifying functional regions of the TSH receptor (TSHr), we immunized four rabbits with recombinant extracellular TSHr (ETSHr) protein and systematically evaluated their antibody response. The antibody response was characterized by testing serial serum samples for immunoglobulin G (IgG) against ETSHr protein and 26 synthetic peptides which span the entire ETSHr. Sera were also tested for their ability to block TSH binding to native TSHr. All four rabbits developed high serum IgG titers (>1:100,000) to ETSHr. None of the rabbits developed significant IgG titers against 11 of the peptides, but each showed persistent high titers against several of the others. After multiple inoculations of antigen, sera from 3 rabbits showed significant ability to block TSH binding. Based on the ability of peptides to reverse this blocking activity, we identified 3 regions of the TSHr (i.e. amino acids 292-311, 367-386, and 397-415) through which antibodies can block TSH binding. Moreover, antibodies purified on either peptide 292-311 or peptide 367-386 affinity columns could block both TSH binding and TSH-mediated activation of thyroid cells in culture. These studies show ETSHr protein is sufficient to induce production of functionally relevant antibodies. Furthermore, we have identified several sites on the TSHr through which antibodies can inhibit TSH binding, thus leading to identification of several potential TSH-binding regions.
From Semantic Search & Integration to Analytics (2005)

Semantics is seen as the key ingredient in the next phase of the Web infrastructure as well as the next generation of enterprise content management. Ontology is the centerpiece of the most prevalent semantic technologies and provides the basis of representing, acquiring, and utilizing knowledge. With the availability of several commercial products and many research tools, specifications and increasing adoption of Semantic Web standards such as RDF for metadata and OWL for ontology representation, ontology-driven techniques and systems have already enabled a new generation of industry strength semantic applications. In particular, Semagix’s Freedom has powered applications in leading verticals such as, financial services, government & intelligence, pharmaceuticals, and media & entertainment. In this paper, we portray some of the requirements of high-end enterprise applications requiring search to integration, and more advanced analytical capabilities, discuss the enterprise scale capabilities expected of a semantic technology, and how Semagix has put an ontology-driven approach to use.
Motion noise cancellation in seismocardiogram of ambulant subjects with dual sensors (2016)

This paper presents a dual-sensor method of extracting seismocardiographic (SCG) data from moving adult subjects using chest-worn wireless MEMS accelerometers. A digital signal processing (DSP) system including a normalized least means square (NLMS) adaptive filter is designed and tested in MATLAB. Data results from 10 subjects indicate a detection rate of 98.72% which outperforms our previously-proposed single-sensor scheme. Various sensor positons and possible failure mechanisms are also investigated to further evaluate the system performance. The results reveal that the quality of the SCG signal from moving subjects could be improved by integrating information from multiple sensors at the cost of increasing system complexity.
Best Practices on HVAC Design to Minimize the Risk of COVID-19 Infection within Indoor Environments (2020)

The spread of Coronavirus is causing in the society all around the world a considerable degree of fear, worry and concern and particularly among healthcare workers that are at increased risk for infection. This paper gathers the strategy/guidelines to reduce the contamination in Intensive care unit (ICU) and in all the hospital environment. The ASHRAE and REHVA guidelines applied the UV-C Lamps, Pressure control filtration, Restroom actions and Humidity control to reduce the coronavirus disease (Covid-19) in ICU. The role of infection control in the design of hospitals is increasing every day. This paper highlights the role of heating, ventilating and air-conditioning minimizing the risk of infection from airborne transmission within the built environment through the application of best practices.
Dedicated module access in dynamically reconfigurable systems (2006)

Modern FPGAs, such as the Xilinx Virtex-II series, offer the feature of partial and dynamic reconfiguration, allowing to load various hardware configurations (i.e., HW modules) during run-time. To enable communication with these modules and for controlling purposes, dedicated access to each module as well as dedicated signals to control the global communication are required. This paper discusses several ways of implementing dedicated signals and addresses the impact on dynamically reconfigurable systems. Two new approaches are introduced, which allow a permanent access to the modules and to the communication infrastructure even during reconfiguration
A 800 V Hybrid IGBT Having a High-Speed Internal Diode for Power-Supply Applications (2007)

A new lateral 800 V hybrid IGBT with a high-speed internal diode is proposed for switch-mode power supply (SMPS) applications. The hybrid IGBT operates as a MOS only when the collector/drain current is small. Then, the device shifts to IGBT operation with an RonA of 72mΩcm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> when the collector voltage is 6V. The switching speed of the device is made fast enough to turn off in around 100 nsec, achieved through several methods such as a shorted anode structure, a lightly- doped collector, and electron irradiation. Besides that, the hybrid IGBT has a high-speed internal diode which achieves around 100 nsec of reverse recovery time (trr). The device can be fabricated easily without any expensive or complicated processes like epitaxial growth or trench etching. A 70 W flyback SMPS application using the hybrid IGBT is experimentally demonstrated.
Dimerization of two novel apoptosisinducing proteins and its function in regulating cell apoptosis (2003)

Asy (apoptosis/saibousi Yutsudo) is a novel apoptosis-inducing gene found in 1999 by Yutsudo group in Japan. In 2000, Qi Bing et al. cloned another novel gene, named hap (homologue of ASY protein), which encoded the ASY interacting protein, from human lung cell line (WI-38) cDNA library by using yeast two-hybrid system. It has been proved that ASY formed homodimer in yeast and human cell line, ASY and HAP formed heterodimer in yeast cells, and both induced cell apoptosis in human tumor cell lines Sao2 and CGL4. This paper showed that HAP could form homodimer in yeast cells by yeast two-hybrid system; HAP and ASY could produce heterodimer in human cell line by cross-immunoprecipitation test; by using apoptosis-testing technologies such as AnnexinV, TUNEL, DNA ladder and Flow Cytometry, the cell apoptosis in human normal or tumor cell lines transfected with hap or asy individually or cotransfected by the both was qualified or quantified. It was firstly demonstrated that ASY or HAP induced cell apoptosis not only in human tumor cell lines, but also in human normal cell lines. Moreover, we proved that the heterodimer between ASY and HAP decreased apoptosis-inducing activity from the homodimer of ASY or HAP. It revealed that by choosing to form heterodimer or homodimer between ASY and / or HAP is an important mechanism of regulating apoptosis in human cell lines.
Specific contribution of human T‐type calcium channel isotypes (α<sub>1G</sub>, α<sub>1H</sub> and α<sub>1I</sub>) to neuronal excitability (2002)

In several types of neurons, firing is an intrinsic property produced by specific classes of ion channels. Low-voltage-activated T-type calcium channels (T-channels), which activate with small membrane depolarizations, can generate burst firing and pacemaker activity. Here we have investigated the specific contribution to neuronal excitability of cloned human T-channel subunits. Using HEK-293 cells transiently transfected with the human alpha(1G) (Ca(V)3.1), alpha(1H) (Ca(V)3.2) and alpha(1I) (Ca(V)3.3) subunits, we describe significant differences among these isotypes in their biophysical properties, which are highlighted in action potential clamp studies. Firing activities occurring in cerebellar Purkinje neurons and in thalamocortical relay neurons used as voltage clamp waveforms revealed that alpha(1G) channels and, to a lesser extent, alpha(1H) channels produced large and transient currents, while currents related to alpha(1I) channels exhibited facilitation and produced a sustained calcium entry associated with the depolarizing after-potential interval. Using simulations of reticular and relay thalamic neuron activities, we show that alpha(1I) currents contributed to sustained electrical activities, while alpha(1G) and alpha(1H) currents generated short burst firing. Modelling experiments with the NEURON model further revealed that the alpha(1G) channel and alpha(1I) channel parameters best accounted for T-channel activities described in thalamocortical relay neurons and in reticular neurons, respectively. Altogether, the data provide evidence for a role of alpha(1I) channel in pacemaker activity and further demonstrate that each T-channel pore-forming subunit displays specific gating properties that account for its unique contribution to neuronal firing.
Role of Oxidative Modifications in Atherosclerosis (2004)

This review focuses on the role of oxidative processes in atherosclerosis and its resultant cardiovascular events. There is now a consensus that atherosclerosis represents a state of heightened oxidative stress characterized by lipid and protein oxidation in the vascular wall. The oxidative modification hypothesis of atherosclerosis predicts that low-density lipoprotein (LDL) oxidation is an early event in atherosclerosis and that oxidized LDL contributes to atherogenesis. In support of this hypothesis, oxidized LDL can support foam cell formation in vitro, the lipid in human lesions is substantially oxidized, there is evidence for the presence of oxidized LDL in vivo, oxidized LDL has a number of potentially proatherogenic activities, and several structurally unrelated antioxidants inhibit atherosclerosis in animals. An emerging consensus also underscores the importance in vascular disease of oxidative events in addition to LDL oxidation. These include the production of reactive oxygen and nitrogen species by vascular cells, as well as oxidative modifications contributing to important clinical manifestations of coronary artery disease such as endothelial dysfunction and plaque disruption. Despite these abundant data however, fundamental problems remain with implicating oxidative modification as a (requisite) pathophysiologically important cause for atherosclerosis. These include the poor performance of antioxidant strategies in limiting either atherosclerosis or cardiovascular events from atherosclerosis, and observations in animals that suggest dissociation between atherosclerosis and lipoprotein oxidation. Indeed, it remains to be established that oxidative events are a cause rather than an injurious response to atherogenesis. In this context, inflammation needs to be considered as a primary process of atherosclerosis, and oxidative stress as a secondary event. To address this issue, we have proposed an "oxidative response to inflammation" model as a means of reconciling the response-to-injury and oxidative modification hypotheses of atherosclerosis.