gebhart/patrepeval huggingface dataset:
An ATR−FTIR Study of Glyphosate and Its Fe(III) Complex in Aqueous Solution (1998)

An ATR−FTIR study of the vibrational spectrum of glyphosate (N-phosphonomethylglycine) in aqueous solution 1 M in NaCl is reported. Band assignments are given in the 1800−850 cm-1 range based on the analysis of the spectral changes from low to high pH values (2−11). Potentiometric titrations of glyphosate are performed at 0.1, 0.5, and 1 M ionic strengths in NaCl and the pKa2, pKa3, and pKa4 values determined. A chemometric analysis of the spectral data has been carried out to support the assignments and reproduce the pKa values. In addition, the ATR−FTIR spectrum of the 1:1 Fe(III)/glyphosate complex in aqueous solution is analyzed by comparison with that of the free ligand.
Co<sub>3</sub>O<sub>4</sub> Nanowire@MnO<sub>2</sub> Ultrathin Nanosheet Core/Shell Arrays: A New Class of High‐Performance Pseudocapacitive Materials (2011)

A smart hybrid nanowire array consisting of Co3O4 porous nanowire core and a MnO2 ultrathin nanosheet shell is fabricated using a general 3D interfacial carbon-assisted hydrothermal method. The array exhibits a high capacitance with good cycle performance and remarkable rate capability that is ranging among the best reported to date for hybrid metal oxide systems in the absence of a conducting matrix. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Isolation and characterization of rabbit anti-m<sup>7</sup>G-5′-P antibodies of high apparent affinity (1979)

Antibodies highly specific for intact pm7G (7methylguanosine-5'-mono-phosphate) were induced by immunization of rabbits with a pm7G-BSA conjugate. Since the nucleotide is six-fold more stable than m7G (7-methylguanosine) to alkali-catalyzed fission of the imidazole ring, it is a more desirable antigen for obtaining antibodies capable of binding caps on eukaryotic mRNA. UV spectra demonstrated that the nucleotide in the conjugate was predominantly the intact form. Competition radioimmunoassay showed 1) high apparent affinities for pm7G, on the order of 10(-8)M, 2) low competition by the ring-opened form of the homologous hapten (*pm7G), and by m7G, 3) little or no competition by AMP, GMP, CMP, UMP or m6A, and 4) high apparent affinities for m7GpppAm, m7GpppN6MAm, m7GpppGm, m7GpppA.
Fast DNA isolation from Histoplasma capsulatum: methodology for arbitrary primer polymerase chain reaction-based epidemiological and clinical studies (1993)

The arbitrary primer polymerase chain reaction (also called random amplified polymorphic DNA, or RAPD) is a DNA fingerprinting method that provides an efficient, sensitive way of discriminating between independent isolates of Histoplasma capsulatum, but its widespread application has been hampered by the arduous 2-day procedure traditionally used to extract DNA from H. capsulatum. We present here a quick (approximately 2-h) extraction method and show that the resultant DNA is suitable for sensitive and reproducible identification of individual strains of this pathogenic fungus.
L'acetoxy-1 dodecene 3 E, composant principal de la pheromone sexuelle de la Teigne de la betterave, Scrobipalpa ocellatella Boyd (Lepidoptera Gelechiidae) (1980)

National audience
Rodent reservoirs of future zoonotic diseases (2015)

The increasing frequency of zoonotic disease events underscores a need to develop forecasting tools toward a more preemptive approach to outbreak investigation. We apply machine learning to data describing the traits and zoonotic pathogen diversity of the most speciose group of mammals, the rodents, which also comprise a disproportionate number of zoonotic disease reservoirs. Our models predict reservoir status in this group with over 90% accuracy, identifying species with high probabilities of harboring undiscovered zoonotic pathogens based on trait profiles that may serve as rules of thumb to distinguish reservoirs from nonreservoir species. Key predictors of zoonotic reservoirs include biogeographical properties, such as range size, as well as intrinsic host traits associated with lifetime reproductive output. Predicted hotspots of novel rodent reservoir diversity occur in the Middle East and Central Asia and the Midwestern United States.
An Improved Description of Separation and Performance Capabilities of Liquid Scintillation Counters Used in Dual Isotope Studies. (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Improved Description of Separation and Performance Capabilities of Liquid Scintillation Counters Used in Dual Isotope Studies.P. D. Klein and W. J. EislerCite this: Anal. Chem. 1966, 38, 11, 1453–1457Publication Date (Print):October 1, 1966Publication History Published online1 May 2002Published inissue 1 October 1966https://pubs.acs.org/doi/10.1021/ac60243a003https://doi.org/10.1021/ac60243a003research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Diagnostics of asymmetrically coated semiconductor lasers (1991)

The authors present a simple diagnostic procedure for lasers that have a priori unknown facet reflectivities. The most important laser parameters that can be extracted are the cavity decay rate Gamma /sub c/ (equal to the inverse of the photon lifetime), the mirror loss coefficient alpha /sub m/ identical to -1/2 L In R/sub 1/R/sub 2/, the internal loss coefficient alpha /sub i/, the facet reflection coefficients R/sub 1/ and R/sub 2/, the spontaneous emission factor n/sub sp/, and the differential gain xi /sub l/. The authors have verified the procedure by applying it to lasers with a priori known facet reflection coefficients, these lasers were weakly index guided (VSIS and CSP types).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity (2006)

Hypoxia is a feature of the microenvironment of a growing tumor. The transcription factor NFκB is activated in hypoxia, an event that has significant implications for tumor progression. Here, we demonstrate that hypoxia activates NFκB through a pathway involving activation of IκB kinase-β (IKKβ) leading to phosphorylation-dependent degradation of IκBα and liberation of NFκB. Furthermore, through increasing the pool and/or activation potential of IKKβ, hypoxia amplifies cellular sensitivity to stimulation with TNFα. Within its activation loop, IKKβ contains an evolutionarily conserved LxxLAP consensus motif for hydroxylation by prolyl hydroxylases (PHDs). Mimicking hypoxia by treatment of cells with siRNA against PHD-1 or PHD-2 or the pan-prolyl hydroxylase inhibitor DMOG results in NFκB activation. Conversely, overexpression of PHD-1 decreases cytokine-stimulated NFκB reporter activity, further suggesting a repressive role for PHD-1 in controlling the activity of NFκB. Hypoxia increases both the expression and activity of IKKβ, and site-directed mutagenesis of the proline residue (P191A) of the putative IKKβ hydroxylation site results in a loss of hypoxic inducibility. Thus, we hypothesize that hypoxia releases repression of NFκB activity through decreased PHD-dependent hydroxylation of IKKβ, an event that may contribute to tumor development and progression through amplification of tumorigenic signaling pathways.
Cardiovascular calcification in end‐stage renal disease (2002)

Cardiovascular diseases are common in patients with end-stage renal disease (ESRD) and cardiovascular morbidity and mortality among dialysis patients are substantially higher than in the general population. The reasons for this high incidence are multiple. They include traditional factors such as hypertension, diabetes, dyslipidaemia, sodium overload, and elevated homocysteine levels as well as disturbances of mineral metabolism, specifically abnormalities in phosphorus and calcium homeostasis. This review will describe the specific cardiovascular complications related to calcifications in ESRD, the implications of the abnormalities of mineral metabolism in its pathogenesis and the current imaging techniques available for the detection of cardiovascular calcifications. Excess of calcium load contributes to the development of cardiac calcifications; therefore, alternative strategies to diminish exogenous calcium load should be considered in patients with ESRD.
Introduction (2011)

The rationale behind this book is to provide a practitioner’s insider perspective on a convert community’s approach to tackling violent extremism during the early 1990s and up until 2009. The significance of conducting this research can best be illustrated by reference to practitioner authors in another field of study, namely, education, and their attempts to gain credibility by articulating theoretical frameworks that inform successful and established practices. Whitehead and McNiff observe: while practitioner research is generally held in high regard for its contributions to quality practice, it is not held in equal regard for its potential contributions to quality theory. Part of the reason is that its methods for assessing quality have not yet been fully worked out, and in some cases not even addressed. (Whitehead and McNiff 2009: 1)
Carotid to femoral pulse wave velocity (2011)

The tape measure distance from CA-FA, multiplied by 0.8, corresponds best with the real travelled aortic path length. This distance is moderately (yet statistically significantly) influenced by age and minimally by BMI.
Preliminary safety and efficacy of IPI-145, a potent inhibitor of phosphoinositide-3-kinase-δ,γ, in patients with relapsed/refractory CLL. (2013)

7070 Background: Phosphoinositide-3-kinases (PI3Ks) are pivotal in cell signaling and regulate a variety of cellular functions relevant to oncogenesis. IPI-145, a potent oral inhibitor of the PI3KEδ and PI3K-γ isoforms, is in clinical development for patients (pts) with hematologic malignancies. Early results in pts with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) from an ongoing Phase I study are reported here. Methods: This dose-escalation study evaluates the safety, maximum tolerated dose (MTD), clinical activity, and pharmacokinetics (PK) of IPI-145. Expansion cohorts (EC) < MTD are allowed. IPI-145 is given orally twice daily (BID) in 28-day cycles. Tumor response is based on modified IWCLL guidelines criteria. Results: 55 pts have been dosed with IPI-145. PK, available through 50 mg BID, are linear with continuous 24 hr inhibition of pAKT (Ser473) in primary pt CLL cells after a single dose of 25 mg. In the 16 pts with CLL (5 pts in dose escalation < 25 mg BID and 11 pts in a 25 mg BID EC), the median [range] number of cycles was 2.7 [1–14] and 81% remain on study. Treatment-related adverse events (TRAEs) occurred in 10 (63%) pts with CLL, a similar incidence as seen in the total study population (56%). The most common > Grade 3 TRAE in pts with CLL was neutropenia (25%). No > Grade 3 ALT elevations occurred in pts with CLL. Among evaluable pts with CLL (n=11), 82% (n=9) had a PR or nodal response after 2 cycles of IPI-145, with a best response to date of 6 PR, 4 SD (all nodal responses), and 1 PD. Conclusions: IPI-145 appeared well tolerated and has shown clinical activity at the doses examined in pts with relapsed/refractory advanced CLL. The single agent MTD has not been determined and dose escalation continues. Updated safety and efficacy data from pts with CLL enrolled in dose escalation and ECs evaluating 25 mg BID and a higher dose (<MTD) of IPIE145 will be presented. Clinical trial information: NCT01476657.
Cholesterol-based anchors and tethers for phospholipid bilayers and for model biological membranes (2010)

This review covers the range of cholesterol-based anchors and tethers and the ways in which they are being used. These cholesterol conjugates provide us with a very flexible ‘tool-box’ that can be used to tether phospholipid bilayers to surfaces, to join bilayers together (bilayer-to-bilayer, bilayer-to-vesicle, vesicle-to-vesicle, etc.) or to anchor molecules, biomolecules, macromolecules or particulate species to the surface of the bilayer. Model biomembranes tethered to a solid support provide a stable platform for addressing membrane components in vitro using force field and spectroscopic methods and since these membranes generally remain fluid and retain much of their biological activity, solid-supported membranes can also be use to study aspects of membrane biology and biochemistry. Potential medical applications are developing out of our ability to anchor ‘markers’ and antibodies to phospholipid vesicles. Compared to anchors in which the anchoring group is a phospholipid (or phospholipid-like) moiety, cholesterol-based anchors are generally easier to make and purify but the anchoring is less strong and this can be an issue when the ‘payload’ is large and water-soluble. In the case of nucleic acid functionalised systems this problem has been addressed by anchoring each oligonucleotide through two cholesteryl end-groups.
A Portable Image Overlay Projection Device for Computer-Aided Open Liver Surgery (2011)

Image overlay projection is a form of augmented reality that allows surgeons to view underlying anatomical structures directly on the patient surface. It improves intuitiveness of computer-aided surgery by removing the need for sight diversion between the patient and a display screen and has been reported to assist in 3-D understanding of anatomical structures and the identification of target and critical structures. Challenges in the development of image overlay technologies for surgery remain in the projection setup. Calibration, patient registration, view direction, and projection obstruction remain unsolved limitations to image overlay techniques. In this paper, we propose a novel, portable, and handheld-navigated image overlay device based on miniature laser projection technology that allows images of 3-D patient-specific models to be projected directly onto the organ surface intraoperatively without the need for intrusive hardware around the surgical site. The device can be integrated into a navigation system, thereby exploiting existing patient registration and model generation solutions. The position of the device is tracked by the navigation system's position sensor and used to project geometrically correct images from any position within the workspace of the navigation system. The projector was calibrated using modified camera calibration techniques and images for projection are rendered using a virtual camera defined by the projectors extrinsic parameters. Verification of the device's projection accuracy concluded a mean projection error of 1.3 mm. Visibility testing of the projection performed on pig liver tissue found the device suitable for the display of anatomical structures on the organ surface. The feasibility of use within the surgical workflow was assessed during open liver surgery. We show that the device could be quickly and unobtrusively deployed within the sterile environment.
M-Views: A System for Location-Based Storytelling (2003)

M-Views is a system for creating and participating in context-sensitive, mobile cinematic narratives. A Map Agent detects participant location in 802.11 enabled space and triggers a location appropriate video message which is sent context -aware systems, participatory media, wireless indoor location awareness, mobile cinema, storytelling
Palladium-Catalyzed Synthesis of Arylamines from Diphenyliodonium Tetrafluoroborate and Secondary Amine (1996)

Abstract The hetero-cross coupling reaction of diphenyliodonium tetrafluoro-borate with secondary amine in the presence of LiNTMS2 or NaOtBu as base, Pd2(dba)3°CHCl3 as catalyst, and tri-o-tolylphosphine as ligand afforded arylamines at room temperature under mild conditions.
Plastic phases in globular phosphorus compounds. A new structural criterion for plastic behavior (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPlastic phases in globular phosphorus compounds. A new structural criterion for plastic behaviorMichele Postel and Jean G. RiessCite this: J. Phys. Chem. 1977, 81, 26, 2634–2637Publication Date (Print):December 1, 1977Publication History Published online1 May 2002Published inissue 1 December 1977https://pubs.acs.org/doi/10.1021/j100541a011https://doi.org/10.1021/j100541a011research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Multiplexed ferroelectric liquid crystal display (1988)

Abstract The studies on the fundamental requirements for realization of a multiplexed ferroelectric liquid crystal (FLC) display have been presented as follows: (1) The new classes of 2,5-diphenylpyrimidine FLCs are useful as a blending component for broadening the Sc temperature range and improving the switching response time. (2) A FLC material with the Iso-N-SA-Sc phase transition sequence as well as the long Sc and N helical pitches is required to achieve the homogeneous alignment in a Sc phase. (3) Among the FLC cells with various alignment layers, the PI/PI coated cell exhibits the symmetric and steep bistability threshold behavior. (4) The parameters to evaluate the multiplexing capability of a FLC cell are introduced and applied to select a suitable combination of alignment layers for highly multiplexing. (5) The parameters are also used to evaluate a favorable drive method among the drive schemes proposed so far for multiplexing a FLC cell. On the basis of the above studies, a multicolor ferroelectric LCD with 639x400 pixels in an A4 size has been developed.
Modification of a Household Microwave Oven for Continuous Temperature and Weight Measurements During Drying of Foods (2000)

The main objective of this study was to modify a conventional household microwave oven for recording temperature and weight measurements continuously during microwave drying of foods. A household microwave oven with digital control was equipped with an electronic balance and a set of standard thermocouples that were connected to a PC for continuous data collection. The efficiency of the modified thermocouples was tested against the built-in probe of the oven. It was found that this microwave oven dryer set-up could be used for drying kinetics studies of foods since both the temperature and weight of the sample could be recorded continuously during the microwave drying operation.
Temperature Dependence of Microwave Phonon Attenuation (1965)

Measurements of the temperature dependence of the attenuation of 9-Gc/sec phonons are presented. They include measurements on crystals of quartz, CdS, GaAs, Ge, Si, Ca${\mathrm{F}}_{2}$, ${\mathrm{Al}}_{2}$${\mathrm{O}}_{3}$, and MgO in several directions and modes of polarization. The attenuation in most of the materials is proportional to ${T}^{n}$, where the average value of $n=4.1\ifmmode\pm\else\textpm\fi{}1.2$ for the fast transverse waves, 4.0\ifmmode\pm\else\textpm\fi{}1.7 for the slow transverse waves, 4.8\ifmmode\pm\else\textpm\fi{}1.4 for the longitudinal waves. For MgO and ${\mathrm{Al}}_{2}$${\mathrm{O}}_{3}$ the attenuation is proportional to the frequency of the sound between 3 and 9 Gc/sec. An empirical correlation of the data is that the attenuation of 9-Gc/sec phonons is 3 dB/cm when $(\frac{T}{\ensuremath{\Theta}})\ensuremath{\approx}0.1$, where $\ensuremath{\Theta}=\mathrm{Debye}\mathrm{temperature}\mathrm{of}\mathrm{the}\mathrm{crystal}$. Values of the third-order elastic constants are used to make absolute comparisons of the theory of attenuation by three-phonon processes with the data. The agreement is good in some cases but not in others.
Physiological properties of a Pseudomonas strain which grows with p-xylene in a two-phase (organic-aqueous) medium (1992)

Pseudomonas putida Idaho utilizes toluene, m-xylene, p-xylene, 1,2,4-trimethylbenzene, and 3-ethyltoluene as growth substrates when these hydrocarbons are provided in a two-phase system at 5 to 50% (vol/vol). Growth also occurs on Luria-Bertani medium in the presence of a wide range of organic solvents. The ability of the organism to grow in the presence of organic solvents is correlated with the logarithm of the octanol-water partition coefficient, with dimethyl-phthalate (log P(OCT) = 2.3) being the most polar solvent tolerated. During growth with p-xylene (20% [vol/vol]), there was an initial lag period accompanied by cell death, which was followed by a period of exponential growth. The stationary phase of growth was characterized by a dramatic decrease in cell viability, although cell dry weight and turbidity measurements slowly increased. Electron micrographs revealed that during growth in the presence of p-xylene, the outer cell membrane becomes convoluted and membrane fragments are shed into the culture medium. At the same time, the cytoplasmic membrane invaginates, forming vesicles, and becomes disorganized. Electron-dense intracellular inclusions were observed in cells grown with p-xylene (20% [vol/vol]) and p-xylene vapors, which are not present in cells grown with succinate. Attempts to demonstrate the presence of plasmid DNA in P. putida Idaho were negative. However, polarographic studies indicated that the organism utilizes the same pathway for the degradation of toluene, m-xylene, and p-xylene as that used by P. putida mt-2 which contains the TOL plasmid pWWO.(ABSTRACT TRUNCATED AT 250 WORDS)