gebhart/patrepeval huggingface dataset:
Dynamic recovery for survivable virtual network embedding (2014)

网络虚拟化是克服因特网的当前的骨化的一个有希望的方法。发现有效、有效、柔韧为恢复虚拟网络嵌入算法是必要挑战。基于是的整数编程印射算法的虚拟网络以前建议了月。但是它确实认为物理网络资源的差错，它是那么把 survivable 称为嵌入的虚拟网络(VNE ) 问题。为在集中于为物理网络提供保护或由提供提高虚拟网络的网络虚拟化的创新 survivability 的以前的策略预先备份物理资源，并且把所有物理失败当作了连接 failures.In 文章，一个动态恢复方法被建议解决 survivable 基于整数编程 VNE 算法嵌入问题的虚拟网络。动态恢复方法不需要备份物理资源，它做能在嵌入被使用的更多的底层资源。仅仅当物理失败发生时，动态恢复过程将被激活。不同算法习惯于恢复节点和连接失败。没有考虑物理失败，方法帮助由发现代用品节点和路径物理失败恢复几乎所有的模拟表演，和它的表演离纯 VNE 方法的很靠近。
Demodectic Rosaceae in a Diabetic Patient (2013)

Sebotropic mites have been implicated in the pathogenesis of several dermatoses in humans. A 46 year old male diabetic patient presented with painful, erythematous, papular, rosacea-like eruptions over bilateral cheeks and a rhinophyma of the nasal tip. The lesions were persistent for two years, with negative slit skin smears and unresponsive to treatment attempts. A skin biopsy revealed demodex mite with superadded dermatophyte infection. This case is a testament to the view that demodex mites are pathogenetic in certain circumstances.
Targeted Site-Specific Gas-Phase Cleavage of Oligoribonucleotides. Application in Mass Spectrometry-Based Identification of Ligand Binding Sites (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTargeted Site-Specific Gas-Phase Cleavage of Oligoribonucleotides. Application in Mass Spectrometry-Based Identification of Ligand Binding SitesRichard H. Griffey, Michael J. Greig, Haoyun An, Henri Sasmor, and Sherilynn ManaliliView Author Information Ibis Therapeutics, a division of Isis Pharmaceuticals 2292 Faraday Ave., Carlsbad, California 92008 Cite this: J. Am. Chem. Soc. 1999, 121, 2, 474–475Publication Date (Web):December 29, 1998Publication History Received1 September 1998Published online29 December 1998Published inissue 1 January 1999https://pubs.acs.org/doi/10.1021/ja983131xhttps://doi.org/10.1021/ja983131xrapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views156Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cytosine,Dissociation,Genetics,Ions,Ligands Get e-Alerts
Using ecological criteria to design plant collection strategies for drug discovery (2003)

Tropical forests are one of the most diverse and endangered habitats on earth. They have also been portrayed as a source of future pharmaceuticals, yet finding useful compounds can be both scientifically and politically challenging. Increasingly, over the past decade, the potential value of medicinal compounds derived from plants, microorganisms, and animals has been proposed as a tangible benefit of biodiversity, and therefore a basis for promoting its preservation. Ecological theories of plant defense can increase the probability of discovering compounds with activity in bioassays against human disease targets. In addition, conducting research in tropical countries with local scientists provides immediate and lasting benefits for the sustainable use of biodiversity. This new approach to drug discovery has been effective in identifying bioactive leads. It is both an important step towards understanding the medicinal value of biodiversity, and a practical way to link drug discovery with conservation.
Arachidonic acid metabolism by human monocytes. Studies with platelet-depleted cultures. (1983)

Purified human monocytes release and metabolize endogenous arachidonic acid (20:4) from phospholipid stores when challenged with particulate inflammatory stimuli or the calcium ionophore A23187. Using radiolabeled cultures, the percentage of total [3H]20:4 released was similar with each type of stimulus. However, the spectrum of 20:4 metabolites differed. With opsonized zymosan (OpZ) or Sephadex beads coated with IgG immune complexes (Ig-beads), the predominant product was thromboxane (25% of the total) together with smaller amounts of other cyclo-oxygenase products and lipoxygenase metabolites. Levels of thromboxane synthesis by monocytes were comparable to those by platelets, as measured by radioimmunoassay. In contrast, exposure to the nonspecific agent A23187 led to mainly lipoxygenase products (70% of the total). Monocytes isolated from mononuclear cell fractions of peripheral blood contain platelets specifically rosetted to their surfaces. These platelet contaminants were removed by sequential incubations of monocytes in serum and EDTA followed by adherence and detachment from tissue culture vessels. The presence of platelets in routinely isolated monocytes presented a major difficulty in the study of human monocyte 20:4 metabolism since platelets also synthesize thromboxane. Loss of 12-HETE synthesis (16-fold reduction relative to 5-HETE) in A23187-stimulated cultures provided a convenient measure of platelet depletion. This together with the response to monocyte-specific stimuli (OpZ and Ig-beads) allowed for the distinction between monocyte and platelet 20:4 metabolism.
Cloning and expression of a human gene encoding an N-acetylgalactosamine- 2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens (1999)

The sialyl-Tn (sTn) antigen is a well known cancer-associated antigen, the expression of which is related to the prognosis of cancer patients. We aimed to isolate a human gene encoding an N -acetylgalactosamine alpha2,6-sialyltransferase which synthesizes sTn antigen, and to characterize the enzyme. Degenerate primers encoding sialyl motifs were used for the polymerase chain reaction to amplify complementary DNAs prepared from RNAs of human pyloric mucosae with intestinal metaplasia, which abundantly expressed sTn antigen, followed by screening of full-length cDNAs using the amplified DNA fragment as a probe. We isolated two human cDNA clones, long-form (2.46 kb) and short-form (2.23 kb) cDNAs. The former encodes an active enzyme with a predicted 600 amino acid sequence. The latter, a splice-variant of the long-form, encodes an inactive enzyme. HCT15 human colorectal cancer cells stably expressing the long-form cDNA expressed sTn epitopes on O -glycans. The long form cDNA was considered to encode a human homologue of chick ST6GalNAc I for the following reasons: (1) the putative amino acid sequence showed greater homology to that of chick ST6GalNAc I (55%) compared to other sialyltransferases, (2) it encodes the extraordinarily long stem region that is a typical feature of chick ST6GalNAc I, and (3) the substrate specificity was very similar to that of chick ST6GalNAc I. In situ hybridization demonstrated that the localization of transcripts correlated well with that of sTn antigen in gastric cancer cells and Goblet cells in intestinal metaplastic glands. Thus, we determined that the long-form cDNA of the human ST6GalNAc I gene encodes the probable candidate for the human sTn synthase(s).
The implementation of hardware subroutines on field programmable gate arrays (2002)

The dynamically reconfigurable Plessey ERA (electrically reconfigurable array), by supporting the paging of full and partial sets of configuration data at system clock speed, allows silicon multitasking and introduces the concept of the hardware subroutine. The ERA requires 2.5 times less data per equivalent gate as compared to the established industry standard devices. In addition, loading the data in parallel bytes at clock speeds up to 25 MHz reduces the time taken for the complete configuration of a 10000 equivalent gate array to less than 140 mu s.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Viscoelastic Computational Modeling of Extruded Micro-textured Polymeric Films (2014)

The feasibility of the production of reduced-coefficient-of-friction micro-textured polymeric films by continuous extrusion using micro-patterned dies made by nonconventional meso-scale micromachining methods has been reported in our previous study [1]. During continuous manufacturing of such polymeric films, the viscoelastic effects of polymeric melts (e.g., die swell) lead to a film micro-texture that is different from the micro-patterned die. Thus, computational studies based on viscoelastic models solved by finite elements methods (FEM) were conducted to predict the die micro-geometries that develop desirable micro-texture shapes. ANSYS Polyflow® was used in conjunction with Cross and Giesekus models to predict the pressure drop and shape/die- swell of isotactic polypropylene films for a rectangular-semicircular micro-pattern. An isothermal, 3-parameter Cross model led to accurate estimation of the pressure drop through the dies, but led to poor estimations of the dimensions of the extrudate. In contrast, a unimodal Giesekus model resulted in over-prediction of the pressure drop (∼ two-fold), but led to accurate prediction of the extrudate shape and size (within an error of 15%) due to the incorporation of viscoelastic effects.
Beneficial Effects of Tumor Necrosis Factor-alpha Inhibition by Pentoxifylline on Clinical, Biochemical, and Metabolic Parameters of Patients with Nonalcoholic Steatohepatitis (2004)

In patients with NASH, pentoxifylline therapy effectively achieved significant clinical and biochemical improvement with reduction in HOMA(IR). These benefits are possibly mediated through suppression of TNF-alpha.
RF multiple-input multiple-output switchless front-end (2006)

RF multiple-input multiple-output circuits are normally implemented with the beam-forming network between the amplifier and antenna. Here the amplifier is placed between the beam-forming network and antenna, thus improving the performance in terms of power loss and noise figure as well as allowing operation for beam steering or spatial diversity.
Calibration and Measurement Procedures for a High Magnification Thermal Camera (2016)

Infrared thermography is a relatively mature measurement technology, however systematic evaluation of measurement uncertainty for multi-point measurement (an infrared focal plane array) is very limited, or, does not follow uncertainty evaluation guidelines outlined in the Bureau International des Poids et Mesures Guide to the Expression of Uncertainty in Measurement (BIPM-GUM). In order to approach uncertainty evaluation of thermographic measurements, a new thermographic calibration and measurement procedure was developed at the National Institute of Standards and Technology (NIST). This method takes from procedures used with single-point radiation pyrometers, which have a more developed background in uncertainty evaluation stemming from their use as calibration transfer instruments. This report details a methodology for calibrating a thermal camera and obtaining temperature measurements, including measurement of emissivity and point spread function. This procedure is performed as a 'post-processing' technique which does not require the camera operating software to convert camera signal to temperature values. In-camera or manufacturer provided calibrations and temperature conversion algorithms may provide sufficiently low measurement uncertainty, however these results are often 'hidden' within the camera operating software and are not readily available for thorough uncertainty analysis, or, these algorithms are known but their form inhibits analytical means for uncertainty analyses.
Leukocyte Activation Detected by Increased Plasma Levels of Inflammatory Mediators in Patients With Ischemic Cerebrovascular Diseases (1996)

Our study demonstrated that markers for systemic leukocyte activation, ie, plasma levels of cytokines and proteases, were higher in patients with acute ischemic cerebrovascular disease than in healthy control subjects. Activated leukocytes and leukocytic mediators may have an important role in acute cerebrovascular ischemia and its consequences.
Quantification of Major Royal Jelly Protein 1 in Fresh Royal Jelly by Indirect Enzyme-Linked Immunosorbent Assay (2013)

Rabbit polyclonal antibody produced by a major royal jelly protein 1 (MRJP1) specific peptide reacted only with a MRJP1. Indirect ELISA with the antibody revealed a MRJP1 level of 4.12-4.67 g/100 g in different company's royal jelly, which almost agreed with that of a hexametric form of MRJP1 (apisin) measured by high performance liquid chromatography. These results suggest that MRJP1 exists mainly as apisin in royal jelly.
Microbial phosphorylation of compactin (ML-236B) and related compounds. (1985)

Several fungal strains were found to convert compactin (ML-236B) to 5'-phosphocompactic acid. The product was isolated by solvent extraction and column chromatography, and identified by IR, UV, 1H NMR, 13C NMR and 31P NMR spectroscopy. Related structures (monacolin K, L and X) were also transformed to their corresponding phosphorylated analogues. The products were re-converted back to respective parental compounds by treatment with alkaline phosphatase of calf intestine.
Tunable graphene quantum point contact transistor for DNA detection and characterization (2015)

A graphene membrane conductor containing a nanopore in a quantum point contact geometry is a promising candidate to sense, and potentially sequence, DNA molecules translocating through the nanopore. Within this geometry, the shape, size, and position of the nanopore as well as the edge configuration influences the membrane conductance caused by the electrostatic interaction between the DNA nucleotides and the nanopore edge. It is shown that the graphene conductance variations resulting from DNA translocation can be enhanced by choosing a particular geometry as well as by modulating the graphene Fermi energy, which demonstrates the ability to detect conformational transformations of a double-stranded DNA, as well as the passage of individual base pairs of a single-stranded DNA molecule through the nanopore.
Perceptual Issues in the Use of Head-Mounted Visual Displays (2006)

Consideration of the basic vision literature will provide insight for future design solutions for HMDs.
Specific visible spectral changes induced by guanine binding to cytosine-derivatized porphyrin (2002)

The interaction of the free nucleic acid bases adenine, cytosine, and thymidine with meso-tri(4-sulfonatophenyl) meso 4-phenyl porphyrin cytosine amide (TPSC) trisodium salt at pH 5.9, 7.4, and 9.3 results is a decrease in the absorbance of the Soret (B-band) at 413 nm of TPSC. A decrease in Soret band absorbance is observed with guanine below pH 8; at higher pH values a new absorbance band at 424 nm is observed. The appearance of the band is consistent with hydrogen bonding between the cytosine-functionalized porphyrin and guanine and the resulting perturbation of the electron orbitals of the porphyrin.
Optische Komponenten (1993)

In diesem Kapitel werden die Wirkungen optischer Komponenten auf das Licht in Form von Reflexion und Brechung zunächst allgemein beschrieben, um dann einige ausgewählte vorzustellen. Im dritten Teil wird ausführlich auf die Aberrationen eingegangen, die im Zusammenhang mit Hochleistungs-CO2-Lasern von Relevanz sind und die Korrelation von Strahldurchmesser, Dejustage, Wellenfrontfehler und der daraus resultierenden Verschlechterung der Fokussierbarkeit hergeleitet. Dabei wird auch der Einfluß des Lasermodes, der sich in der in Kapitel 2 diskutierten Strahlqualität ausdrückt, aufgezeigt und für die wichtigsten Moden exemplarisch dargestellt.
Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A (2009)

The thrombin mutant W215A/E217A (WE) is a potent anticoagulant both in vitro and in vivo. Previous x-ray structural studies have shown that WE assumes a partially collapsed conformation that is similar to the inactive E* form, which explains its drastically reduced activity toward substrate. Whether this collapsed conformation is genuine, rather than the result of crystal packing or the mutation introduced in the critical 215-217 beta-strand, and whether binding of thrombomodulin to exosite I can allosterically shift the E* form to the active E form to restore activity toward protein C are issues of considerable mechanistic importance to improve the design of an anticoagulant thrombin mutant for therapeutic applications. Here we present four crystal structures of WE in the human and murine forms that confirm the collapsed conformation reported previously under different experimental conditions and crystal packing. We also present structures of human and murine WE bound to exosite I with a fragment of the platelet receptor PAR1, which is unable to shift WE to the E form. These structural findings, along with kinetic and calorimetry data, indicate that WE is strongly stabilized in the E* form and explain why binding of ligands to exosite I has only a modest effect on the E*-E equilibrium for this mutant. The E* --> E transition requires the combined binding of thrombomodulin and protein C and restores activity of the mutant WE in the anticoagulant pathway.
Photonic FDM multichannel selector using coherent optical transversal filter (1994)

This paper describes a photonic frequency-division-multiplexing (FDM) multichannel selector using a coherent optical transversal filter and discusses its application to a photonic FDM highway switch. The selector can select several arbitrary channels out of several multiplexed frequency channels. The selector function takes advantage of the fact that the filter can express arbitrary frequency characteristics. An experimental 16-tap filter is fabricated according to silica-based-waveguide technology, which can monolithically integrate a variety of optical components. Arbitrary channel selection and signal transmission characteristics are confirmed by measuring the frequency characteristics of the selector and the bit-error-rate performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Understanding Traffic Density from Large-Scale Web Camera Data (2017)

Understanding traffic density from large-scale web camera (webcam) videos is a challenging problem because such videos have low spatial and temporal resolution, high occlusion and large perspective. To deeply understand traffic density, we explore both optimization based and deep learning based methods. To avoid individual vehicle detection or tracking, both methods map the dense image feature into vehicle density, one based on rank constrained regression and the other based on fully convolutional networks (FCN). The regression based method learns different weights for different blocks of the image to embed road geometry and significantly reduce the error induced by camera perspective. The FCN based method jointly estimates vehicle density and vehicle count with a residual learning framework to perform end-to-end dense prediction, allowing arbitrary image resolution, and adapting to different vehicle scales and perspectives. We analyze and compare both methods, and get insights from optimization based method to improve deep model. Since existing datasets do not cover all the challenges in our work, we collected and labelled a large-scale traffic video dataset, containing 60 million frames from 212 webcams. Both methods are extensively evaluated and compared on different counting tasks and datasets. FCN based method significantly reduces the mean absolute error (MAE) from 10.99 to 5.31 on the public dataset TRANCOS compared with the state-of-the-art baseline.
Non-Linear Transport and Switching Properties of Transition Metal Oxides (1974)

Repetitive switching from the high to the low resistance state in thin crystalline and amorphous films of transition metal oxides such as NiO, NiO(Li), CoO, Nb2O5 and TiO2 is investigated. The switching processes are associated with four conduction states. The transitions among the first three states are reversible and cyclic, exhibiting switching times from 0.1 µsec to 2.5 nsec. The fourth state represents a final and irreversible step in the dielectric breakdown. Transport and dielectric data as a function of doping, voltage, frequency and temperature are used to interpret the nature of the non-linear conduction and switching processes.
A double-sampled path-coupled single-loop &#x03A3;&#x0394; modulator using noise-shaped integrating quantizer (2010)

A single-loop delta-sigma modulator based on path-coupling and double-sampling is proposed. This modulator employs a noise-shaped integrating quantizer which by itself increases the order of noise shaping by one. The integrating quantizer used in this structure holds its quantization error at the end of the evaluation phase, and hence this voltage is available in purely analog form and eliminates the need for extra DACs. This enables to utilize local path-coupling which adds another order of noise shaping. A third order example is provided and simulated to demonstrate the efficiency of this structure.
A Novel Video Tracking Method to Evaluate the Effect of Influenza Infection and Antiviral Treatment on Ferret Activity (2015)

Ferrets are the preferred animal model to assess influenza virus infection, virulence and transmission as they display similar clinical symptoms and pathogenesis to those of humans. Measures of disease severity in the ferret include weight loss, temperature rise, sneezing, viral shedding and reduced activity. To date, the only available method for activity measurement has been the assignment of an arbitrary score by a 'blind' observer based on pre-defined responsiveness scale. This manual scoring method is subjective and can be prone to bias. In this study, we described a novel video-tracking methodology for determining activity changes in a ferret model of influenza infection. This method eliminates the various limitations of manual scoring, which include the need for a sole 'blind' observer and the requirement to recognise the 'normal' activity of ferrets in order to assign relative activity scores. In ferrets infected with an A(H1N1)pdm09 virus, video-tracking was more sensitive than manual scoring in detecting ferret activity changes. Using this video-tracking method, oseltamivir treatment was found to ameliorate the effect of influenza infection on activity in ferret. Oseltamivir treatment of animals was associated with an improvement in clinical symptoms, including reduced inflammatory responses in the upper respiratory tract, lower body weight loss and a smaller rise in body temperature, despite there being no significant reduction in viral shedding. In summary, this novel video-tracking is an easy-to-use, objective and sensitive methodology for measuring ferret activity.