gebhart/patrepeval huggingface dataset:
Designing the user interface for speech recognition applications (1996)

article Designing the user interface for speech recognition applications Share on Authors: Amir Mane View Profile , Susan Boyce View Profile , Demetrios Karis View Profile , Nicole Yankelovich View Profile Authors Info & Claims ACM SIGCHI BulletinVolume 28Issue 4Oct. 1996 pp 29–34https://doi.org/10.1145/242417.242436Published:01 October 1996 6citation35DownloadsMetricsTotal Citations6Total Downloads35Last 12 Months6Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
First-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer (2017)

Purpose Endoxifen is a tamoxifen metabolite with potent antiestrogenic activity. Patients and Methods We performed a phase I study of oral Z-endoxifen to determine its toxicities, maximum tolerated dose (MTD), pharmacokinetics, and clinical activity. Eligibility included endocrine-refractory, estrogen receptor-positive metastatic breast cancer. An accelerated titration schedule was applied until moderate or dose-limiting toxicity occurred, followed by a 3+3 design and expansion at 40, 80, and 100 mg per day. Tumor DNA from serum (circulating cell free [cf); all patients] and biopsies [160 mg/day and expansion]) was sequenced. Results Of 41 enrolled patients, 38 were evaluable for MTD determination. Prior endocrine regimens during which progression occurred included aromatase inhibitor (n = 36), fulvestrant (n = 21), and tamoxifen (n = 15). Patients received endoxifen once daily at seven dose levels (20 to 160 mg). Dose escalation ceased at 160 mg per day given lack of MTD and endoxifen concentrations > 1,900 ng/mL. Endoxifen clearance was unaffected by CYP2D6 genotype. One patient (60 mg) had cycle 1 dose-limiting toxicity (pulmonary embolus). Overall clinical benefit rate (stable > 6 months [n = 7] or partial response by RECIST criteria [n = 3]) was 26.3% (95% CI, 13.4% to 43.1%) including prior tamoxifen progression (n = 3). cfDNA mutations were observed in 13 patients ( PIK3CA [n = 8], ESR1 [n = 5], TP53 [n = 4], and AKT [n = 1]) with shorter progression-free survival ( v those without cfDNA mutations; median, 61 v 132 days; log-rank P = .046). Clinical benefit was observed in those with ESR1 amplification (tumor; 80 mg/day) and ESR1 mutation (cfDNA; 160 mg/day). Comparing tumor biopsies and cfDNA, some mutations ( PIK3CA, TP53, and AKT) were undetected by cfDNA, whereas cfDNA mutations ( ESR1, TP53, and AKT) were undetected by biopsy. Conclusion In endocrine-refractory metastatic breast cancer, Z-endoxifen provides substantial drug exposure unaffected by CYP2D6 metabolism, acceptable toxicity, and promising antitumor activity.
Prostatitis/Chronic Pelvic Pain Syndrome (2005)

We review the diagnosis, categorization, and treatment of prostatitis/chronic pelvic pain syndrome based on the National Institutes of Health (NIH) classification. Prostatitis is an extremely common syndrome that afflicts 2%-10% of men. Formerly a purely clinical diagnosis, prostatitis is now classified within a complex series of syndromes (NIH category I-IV prostatitis) that vary widely in clinical presentation and response to treatment. Acute bacterial prostatitis (category I) and chronic bacterial prostatitis (category II) are characterized by uropathogenic infections of the prostate gland that respond well to antimicrobial treatment. In contrast, chronic prostatitis/chronic pelvic pain syndrome (category III), which accounts for 90%-95% of prostatitis cases, is of unknown etiology and is marked by a mixture of pain, urinary, and ejaculatory symptoms with no uniformly effective therapy. Asymptomatic inflammatory prostatitis (category IV) is an incidental finding of unknown clinical significance. This review describes the current status of prostatitis syndromes and explores the future prospects of new diagnostic tools and therapies.
Does an electronic circuit breaker need electrical contacts? (2004)

Conventional mechanical circuit breakers protect AC and DC circuits from overload and short circuit conditions, and also meet the required physical isolation criteria after contact separation. They are limited in life because of mechanical degradation. Existing RCCB's are hybrid devices that combine the advantages of mechanical circuit breakers that offer lower contact resistance and power loss with electronic remote control functions. Electronic circuit breakers are capable of offering features such as almost unlimited short circuit capacity, programmability of rated current and trip time curve characteristics, wire break indication, and millions of operating cycles without any degradation. Protection against field induced electromagnetic pulses need additional shielding. For this reason, electronic circuit breakers often use an electrical contact in series with the power semiconductor which stays open and in the "OFF"-state, thus withstanding the required isolation voltages. Differences between both types of circuit breakers are discussed in detail based on specific test results and applications. For high DC voltage applications conventional circuit breakers need large air gaps, a sophisticated arc extinguishing method or they use expensive technologies like vacuum or gas filled switching chambers. SSRCCB can meet the requirements in size and performance, but they also need an electrical contact for isolation. We must conclude therefore, that electronic circuit breakers often need electrical contacts.
A Double‐Blind Study on Acupuncture Sensations with Japanese Style of Acupuncture: Comparison between Penetrating and Placebo Needles (2018)

To investigate the acupuncture sensations elicited by the Japanese style of acupuncture, penetrating acupuncture and skin-touch placebo needles were randomly administered at various insertion depths (5 and 10 mm for the penetrating needles and 1 and 2 mm for the placebo needles) at LI4 to 50 healthy subjects. Among the 12 acupuncture sensations in the Massachusetts General Hospital Acupuncture Sensation Scale (MASS), "heaviness" was the strongest and most frequently reported sensation with the 10 mm needles, but not with the 5 mm needles. There were no significant differences in number of sensations elicited, MASS index, range of spreading, and intensity of needle pain for 5 mm penetration versus 1 mm skin press and 10 mm penetration versus 2 mm skin press. The MASS index with 2 mm skin-touch needles was significantly larger than that with 1 mm skin-touch and 5 mm penetrating needles. The factor structures in the 12 acupuncture sensations between penetrating and skin-touch needles were different. The acupuncture sensations obtained in this study under satisfactorily performed double-blind (practitioner-patient) conditions suggest that a slight difference in insertion depth and skin press causes significant differences in quantity and quality of acupuncture sensations.
Highly Efficient and Stable Hybrid White Organic Light Emitting Diodes with Controllable Exciton Behavior by a Mixed Bipolar Interlayer (2016)

Highly efficient and stable hybrid white organic light-emitting diodes (HWOLEDs) with a mixed bipolar interlayer between fluorescent blue and phosphorescent yellow emitting layers are demonstrated. The bipolar interlayer is a mixture of p-type diphenyl (10-phenyl-10H-spiro [acridine-9,9'-fuoren]-3'-yl) phosphine oxide and n-type 2',2''-(1,3,5-benzinetriyl)-tris(1-phenyl-1-H-benzimidazole). The electroluminance and Commission Internationale de l'Eclairage (CIE1931) coordinates' characteristics can be modulated easily by adjusting the ratio of the hole-predominated material to the electron-predominated material in the interlayer. The hybrid WOLED with a p-type:n-type ratio of 1:3 shows a maximum current efficiency and power efficiency of 61.1 cd/A and 55.8 lm/W, respectively, with warm white CIE coordinates of (0.34, 0.43). The excellent efficiency and adaptive CIE coordinates are attributed to the mixed interlayer with improved charge carrier balance, optimized exciton distribution, and enhanced harvesting of singlet and triplet excitons.
Towards a Virtual Garment Fitting Model for Male Upper Body for Online Marketplace (2018)

In online apparel market, there is a high return rate mainly due to the size mismatches. As a solution, Virtual garment technologies have been introduced for finding apparels with precise fit whereas most of these technologies are categorized under commercial 3D applications. Therefore, suitability of these 3D applications to check the fitness of selected garment item to a particular user in online marketplace is less due to network latency issues, the need of high user intervention and computational power albeit to the ability of providing highly accurate fitness for a selected garment. Within this paper, a lightweight solution is presented which assists the decision making process of end users in the online market to select perfectly fitted garment by considering human body measurements and garment measurements. The suggested fitting model is consolidated with 2D patterns of human body and finished garments which has the ability of identifying the fitness and manifesting it using seven predefined areas along with user preference and distance ease values. This research has only concerned on generating the fitting model for short sleeve men's shirts due to the limited time frame. The procedure of generating the 2D block pattern from a finished short sleeve shirt has been discerned through an experiment and standard error values which are associated with aforementioned conversion has been recognized using the experiment results. The implemented model was endeavoured on 20 participants and qualitative approaches were used to evaluate the implemented model resulting an accuracy of 81.2%. A survey was conducted to evaluate the visualization of the system output, and received 76% positive responses
Constant-Current Stressing of SiCr-Based Thin-Film Resistors: Initial “Wearout” Investigation (2007)

We have started an investigation of the ldquowearoutrdquo characteristics of two of our thin-film resistor processes as a part of a product and process transfer. Our goals are the following: 1) to find out what happens to these resistors under accelerated stress and define ldquofailure;rdquo 2) to compare results between ldquoequivalentrdquo resistor films that are independently developed in two of our internal fabs; and 3) to generate better reliability-based design rules as a function of current density, temperature, and resistor geometry. We have characterized the changes in resistance and temperature coefficient of resistivity as a result of accelerated to highly accelerated test conditions, using thermal and constant-current stresses, and determined activation energies for some of these changes. We have found that we can produce resistance increases and resistance decreases, depending on resistor process and stress levels, with an activation energy of about 1 eV for resistance increase for one of the resistor process types at one fabrication site and an activation energy of about 3 eV for the resistance decrease for the other three process type and fabrication-site combinations.
Electron avalanche and surface charging on alumina insulators during pulsed high-voltage stress (1974)

This paper describes a model for insulator surface charging in high-voltage ceramic vacuum diodes. The model involves electron emission from the insulator-cathode-vacuum junction followed by electron avalanches on the insulator surface which leave the wall positively charged. Experiments were performed to measure (i) the triple-junction (cathode-vacuum-insulator interface) emission and its relation to the initiation of the avalanche, (ii) the dynamic current in the avalanche, and (iii) the saturated surface charge resulting from the avalanche. The experimental results were interpreted by computer simulation in terms of the model and were found to be in close agreement with the predictions.
Securing cloud infrastructure against co-resident DoS attacks using game theoretic defense mechanisms (2012)

Evolution in cloud services and infrastructure has been constantly reshaping the way we conduct business and provide services in our day to day lives. Tools and technologies created to improve such cloud services can also be used to impair them. By using generic tools like nmap, hping and wget, one can estimate the placement of virtual machines in a cloud infrastructure with a high likelihood. Moreover, such knowledge and tools can also be used by adversaries to further launch various kinds of attacks. In this paper we focus on one such specific kind of attack, namely a denial of service (DoS), where an attacker congests a bottleneck network channel shared among virtual machines (VMs) coresident on the same physical node in the cloud infrastructure. We evaluate the behavior of this shared network channel using Click modular router on DETER testbed. We illustrate that game theoretic concepts can be used to model this attack as a two-player game and recommend strategies for defending against such attacks.
Apoptosis, proliferation, and angiogenesis in oral tissues. Possible relevance to tumour progression (2000)

Experimental animal models have demonstrated that angiogenesis is essential for tumour progression, whilst sustained tumour growth requires a positive balance between tumour cell proliferation and cell death (apoptosis). The aim of this study was to determine the relative contribution of apoptosis, proliferation, and angiogenesis to disease progression in the oral mucosa. Histological sections of 47 archival specimens were examined; these included four groups of oral tissues: normal mucosa (n=12), moderate dysplasia (n=11) severe dysplasia (n=6), and squamous cell carcinoma (n=18). Apoptotic cells were visualized by in-situ end-labelling of DNA, proliferative cells by staining with Ki-67 antibody, and blood vessels with von Willebrand factor (vWF) antibody. One-way analysis of variance showed that indices of apoptosis (AI), proliferation (PI), and angiogenesis (vascularity) increased significantly with disease progression from normal oral mucosa, through dysplasia, to carcinoma (p<0.0001 for every index). The increase from normal mucosa to moderate dysplasia was significant for PI and vascularity, but not for AI. In contrast, the increase from dysplasia to carcinoma was significant for AI and vascularity, but not for PI. These data suggest that disease progression in the oral mucosa is accompanied by angiogenesis and increases in both epithelial proliferation and apoptosis. Net epithelial growth results from proliferation starting earlier and proceeding at a higher rate than apoptosis.
The S100A4 Metastasis Factor Regulates Cellular Motility via a Direct Interaction with Myosin-IIA (2006)

S100A4, a member of the Ca(2+)-dependent S100 family of proteins, is a metastasis factor that is thought to regulate the motility and invasiveness of cancer cells. Previously, we showed that S100A4 specifically binds to nonmuscle myosin-IIA and promotes the unassembled state. S100A4, thus, provides a connection between the actomyosin cytoskeleton and the regulation of cellular motility; however, the step or steps in the motility cycle that are affected by S100A4 expression have not been investigated. To examine how the biochemical properties of S100A4 affect cell motility, we determined the effect of S100A4 expression on protrusive behavior during chemoattractant-stimulated motility. Our studies show that S100A4 modulates cellular motility by affecting cell polarization, with S100A4 expressing cells displaying few side protrusions and extensive forward protrusions during chemotaxis compared with control cells. To establish a direct link between S100A4 and the regulation of myosin-IIA function, we prepared an antibody to the S100A4 binding site on the myosin-IIA heavy chain that has comparable effects on myosin-IIA assembly as S100A4. Microinjection experiments show that the antibody elicits the same effects on cell polarization as S100A4. Our studies show for the first time that S100A4 promotes directional motility via a direct interaction with myosin-IIA. These findings establish S100A4 as a critical regulator of myosin-II function and metastasis-associated motility.
Modulation of the Microenvironment Surrounding the Active Site of Penicillin G Acylase Immobilized on Acrylic Carriers Improves the Enzymatic Synthesis of Cephalosporins (2013)

The catalytic properties of penicillin G acylase (PGA) from Escherichia coli in kinetically controlled synthesis of β-lactam antibiotics are negatively affected upon immobilization on hydrophobic acrylic carriers. Two strategies have been here pursued to improve the synthetic performance of PGA immobilized on epoxy-activated acrylic carriers. First, an aldehyde-based spacer was inserted on the carrier surface by glutaraldehyde activation (immobilization yield = 50%). The resulting 3-fold higher synthesis/hydrolysis ratio (vs/vh1 = 9.7 ± 0.7 and 10.9 ± 0.7 for Eupergit® C and Sepabeads® EC-EP, respectively) with respect to the unmodified support (vs/vh1 = 3.3 ± 0.4) was ascribed to a facilitated diffusion of substrates and products as a result of the increased distance between the enzyme and the carrier surface. A second series of catalysts was prepared by direct immobilization of PGA on epoxy-activated acrylic carriers (Eupergit® C), followed by quenching of oxiranes not involved in the binding with the protein with different nucleophiles (amino acids, amines, amino alcohols, thiols and amino thiols). In most cases, this derivatization increased the synthesis/hydrolysis ratio with respect to the non derivatized carrier. Particularly, post-immobilization treatment with cysteine resulted in about 2.5-fold higher vs/vh1 compared to the untreated biocatalyst, although the immobilization yield decreased from 70% (untreated Eupergit® C) to 20%. Glutaraldehyde- and cysteine-treated Eupergit® C catalyzed the synthesis of cefazolin in 88% (±0.9) and 87% (±1.6) conversion, respectively, whereas untreated Eupergit® C afforded this antibiotic in 79% (±1.2) conversion.
Sigma-delta modulator with spectrally shaped feedback (2003)

This paper explores the use of finite-impulse response (FIR) filters in the feedback path of a low-pass sigma-delta modulator in order to combat some nonideal effects encountered in an analog implementation. In this approach, the filter corresponding to the first integrator is a lowpass filter which smoothes out the feedback waveform by attenuating the high-frequency quantization noise. This lowpass filtering decreases the power consumption of a switched-capacitor implementation and alternatively reduces the sensitivity to clock jitter in a continuous-time structure. A design methodology ensuring the stability of the system is presented. Theoretical analysis and simulations show that the FIR filters allow a continuous-time single-bit modulator to achieve the jitter performance of a comparable multibit modulator.
Tumor-infiltrating B cells and T cells (2012)

We recently reported a novel cooperative relationship between tumor-infiltrating B cells and CD8(+) T cells in ovarian cancer, leading to increased patient survival. Here, we discuss the mechanisms whereby B cells might enhance cellular immunity, including serving as antigen-presenting cells, organizing tertiary lymphoid structures and secreting polarizing cytokines. The enhancement of both B and T-cell responses may result in more potent and sustained antitumor immunity.
Hybrid magnetic tunnel junction/vertical cavitysurface emittinglaser field sensor device (2001)

A hybrid magneto-optoelectronic device is demonstrated, composed of a magnetic tunnel junction and a vertical cavity surface emitting diode laser. External magnetic field changes are translated into amplitude modulation of the laser output power with sensitivity that suggests applications in wireless and remote sensing of magnetic fields.
Epitaxial growth of YBa2Cu3O7−<i>x</i> thin films by a laser evaporation process (1988)

Thin films of YBa2 Cu3 O7−x have been grown epitaxially in c-axis orientation on 〈100〉 SrTiO3 by pulsed excimer laser evaporation from a stoichiometric 1-2-3 target. The substrate temperature was adjusted between 720 and 780 °C, and the oxygen partial pressure during the deposition was chosen in the range 0.1–0.3 mbar. Cooled to ambient temperature in situ for 1 h in flowing oxygen gas, the films showed complete diamagnetism and zero resistance at 90 K with a transition width of 2 K. Critical current densities of 2.2×106 A/cm2 in zero magnetic field and 1.5×105 A/cm2 at 2 T were measured at 77 K. The resistivity at 100 K was about 60 μΩ cm.
Stereo Odometry – A Review of Approaches (2007)

Abstract — Estimating its ego-motion is one of the most important capabilities for an autonomous mobile platform. Without reliable ego-motion estimation no long-term navigation is possible. Besides odometry, inertial sensors, DGPS, laser range finders and so on, vision based algorithms can contribute a lot of information. Stereo odometry is a vision based motion estimation algorithm that estimates the ego-motion of a stereo camera through its environment by evaluating the captured images. In this paper, we want to give an integrated overview of stereo odometry and the accompanying literature. We want to emphasize the fact that stereo odometry is a chain of several single subprocesses where each relies on its predecessor’s results. A variety of exchangable methods for each of these subprocesses is available. The key to a more accurate and efficient stereo odometry lies in an integrated analysis of its single subprocesses and the many algorithms available. I.
Generating Metadata from Acoustic and Speech Data in Live Broadcasting (2006)

This paper describes a method to generate metadata for TV programs in real-time by utilizing acoustic and speech data in live broadcasting. Various styles of watching TV programs can be provided by using metadata related to the content of the program. The acoustic data to be processed in our case is crowd noise in a football (soccer) stadium, and the speech data is an announcer's voice. The crowd noise is closely related to not only spectator emotions but also their attention and expectations. In other words, a part in which the crowd noise rises corresponds to an important event in the game. Because the crowd noise conveys no further information about what happened in the scene, the announcer's voice, after speech-to-text conversion, is processed to extract further meaning. By combining these two processes of identifying and extracting, content-based segment metadata is generated automatically. This method was applied to generating metadata for six professional football games, by which its effectiveness was verified.
Continuous Motion Picture Projector for Use in Television Film Scanning (1952)

The projector used for this equipment drives a 35mm motion picture film at the standard (nonintermittent) speed of 24 frame/sec and produces a television signal of 525 lines and 30 frames interlaced 2 to 1. The projector utilizes a system of movable plane mirrors mounted on a rotating drum and controlled by a single stationary cam. Vertical jitter in the television image is minimized by means of an electronic servo system operating on the film sprocket holes, resulting in a residual vertical motion of about 1/2000 of a picture height. A second electronic servo system is incorporated to suppress flicker. The combination of this scanner and a high-grade monitor is capable of producing a television picture with a resolution corresponding to about 8 me and with good tone rendition over a range up to 200 to 1.