gebhart/patrepeval huggingface dataset:
Open-path, quantum cascade laser-based sensor for high resolution atmospheric ammonia measurements (2013)

Abstract. We demonstrate a compact, open-path, quantum cascade laser-based atmospheric ammonia sensor operating at 9.06 μm for high sensitivity, high temporal resolution, ground-based measurements. Atmospheric ammonia (NH3) is a gas-phase precursor to fine particulate matter, with implications for air quality and climate change. Currently, NH3 sensing challenges have led to a lack of widespread in-situ measurements. Our open-path sensor configuration avoids sampling artifacts associated with NH3 surface adsorption onto inlet tubing and reduced pressure sampling cells, as well as condensed-phase partitioning ambiguities. Multi-harmonic wavelength modulation spectroscopy allows for selective and sensitive detection of atmospheric-pressure broadened absorption features. An in-line ethylene reference cell provides real-time calibration (±20% accuracy) and normalization for instrument drift under rapidly changing field conditions. The sensor has a sensitivity and minimum detection limit of 0.15 ppbv NH3 at 10 Hz, a mass of ~ 5 kg and consumes ~ 50 W of electrical power. In-situ field performance of this open-path NH3 sensor is demonstrated, with 10 Hz time resolution and a large dynamic response for in-situ NH3 measurements. This sensor provides the capabilities for improved in-situ gas phase NH3 sensing relevant for emission source characterization and flux measurements.
DYSBOT: A single‐blind, randomized parallel study to determine whether any differences can be detected in the efficacy and tolerability of two formulations of botulinum toxin type A—Dysport and Botox—assuming a ratio of 4:1 (1997)

Using a 4:1 conversion ratio for Dysport and Botox, similar results were obtained for the two treatments in an appropriately powered study, suggesting that this conversion factor is a good estimate of their comparative clinical potencies.
GeneX: An Open Source gene expression database and integrated tool set (2001)

Because gene expression profiles are highly sensitive to sample and processing conditions, it is crucial to accurately represent these conditions along with the numeric data in a way that allows the conditions to be part of a query. The GeneX™ project is intended to provide an Open Source database and integrated tool set that will allow researchers to store and evaluate their gene expression data and, moreover, such evaluation will be independent of the technology used to obtain the data.
lnterleukin-1β Converting Enzyme: Biology and the Chemistry of Inhibitors (1995)

Interleukin-1&#946; converting enzyme (ICE) catalyzes processing of biologically inactive pro IL-1&#946; to mature II-1&#946;. IL-1&#946; is implicated in the pathogenesis of a number of inflammatory diseases, suggesting that compounds which inhibit ICE and reduce levels of the mature cytokine may have therapeutic utility. ICE and related homologs also appear to play a role in the pathway leading to apoptosis (programmed cell death), raising the possibility that inhibitors of ICE may be useful in/ &#039; diseases resulting from inappropriate regulation of apoptosis. ICE defines a new class of cysteine protease as confirmed through X-ray crystal structure determination of peptide inhibitor-ICE complexes. The enzyme exists as a (p20)2/(p10)2 tetramer and binds its peptide inhibitors via an extended P-sheet. A variety of strategies for the discovery of inhibitors of ICE have been successfully explored. Peptidyl aspartyl aldehydes and phenylalkyl ketones are potent reversible inhibitors of the enzyme, in analogy with the classic results obtained with other cysteine proteases. Selective irreversible inhibition of ICE is provided by compounds such as aspartyl diazomethyl ketones and aspartyl (arylacyloxy)methyl ketones, which appear to inactivate the enzyme through alkylation of the side chain thiol of Cys285. Several structurally distinct functional groups can replace the (arylacyl)oxy- moiety as a leaving group, including diphenylphosphinic acid and 5-hydroxy-1-phenyl 3- trifluoromethyl-pyrazole. Non-peptidic 3-chloropyridazines have also been described as irreversible inactivators of ICE.
"Hellenisten" in der Apostelgeschichte: Historische und exegetische Untersuchungen zu Apg 6,1; 9,29; 11,20 (2010)

Book Review| January 01 2010 "Hellenisten" in der Apostelgeschichte: Historische und exegetische Untersuchungen zu Apg 6,1; 9,29; 11,20 "Hellenisten" in der Apostelgeschichte: Historische und exegetische Untersuchungen zu Apg 6,1; 9,29; 11,20Zugmann, Michael Joel R. White Joel R. White Search for other works by this author on: This Site Google Bulletin for Biblical Research (2010) 20 (4): 603–604. https://doi.org/10.2307/26424739 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Joel R. White; "Hellenisten" in der Apostelgeschichte: Historische und exegetische Untersuchungen zu Apg 6,1; 9,29; 11,20. Bulletin for Biblical Research 1 January 2010; 20 (4): 603–604. doi: https://doi.org/10.2307/26424739 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All Scholarly Publishing CollectivePenn State University PressBulletin for Biblical Research Search Advanced Search The text of this article is only available as a PDF. Copyright © 2010 by The Pennsylvania State University. All rights reserved.2010The Pennsylvania State University Article PDF first page preview Close Modal You do not currently have access to this content.
Ca<sup>2+</sup>Released During Enzymatic Isolation of Pea Mesophyll Protoplasts Could Enhance Spontaneous Aggregation and Fusion (1992)

The ability of isolated pea (Pisum sativum cv. Ran 1) mesophyll protoplasts to aggregate and fuse spontaneously was examined. Aiming to define whether Ca2+ released during enzymatic isolation of protoplasts and residual in the purified suspension is important for aggregation and fusion, different isolating media were used: Ca2+—free medium, buffered Ca2+—free medium, Ca2 +—free medium containing 2.5 mM EGTA, and medium containing 10 mM CaCl2. Light scattering was measured to assess aggregation and/or fusion and Arsenazo III was used to evaluate free Ca2+. Binding of Ca2+ to plasmalemma was characterized by 9-Aminoac ridine fluorescence. Since light scattering of purified suspensions of protoplasts isolated in the presence of 2.5 mM EGTA was lower as compared to the other variants, a Ca2+—dependent fusion during isolation was suggested. Binding of Ca2+ by 100 μM EGTA slightly reduced the light scattering of suspension of protoplasts isolated without EGTA, indicating existence of Ca2+ dependent aggregation. Titration with CaCl2 (up to 100 mM) completely reduced protoplasts surface potential but failed to increase the aggregation significantly. The results suggested that protoplasts fuse spontaneously in the presence of Ca2+ released by the tissue during isolation. In purified suspensions residual micromolar amount of Ca2+ is sufficient for aggregation.
Health Impact Modelling of Active Travel Visions for England and Wales Using an Integrated Transport and Health Impact Modelling Tool (ITHIM) (2013)

Methods to estimate the health impacts from transport related physical activity and injury risk are in their infancy; this study has demonstrated an integration of transport and health impact modelling approaches. The findings add to the case for a move from car transport to walking and cycling, and have implications for empirical and modelling research.
<i>In Vitro</i> Stem Cell Cultures from Human Dental Pulp and Periodontal Ligament: New Prospects in Dentistry (2007)

In spite of the vast knowledge of tooth development and of the various kinds of specialized bone/tooth-associated cells, the characteristics and properties of their precursor cell populations present in the postnatal organism are little known, as is their possible therapeutic use. Taken together dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs) possess stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation. Regenerative medicine is based on stem cells, signals and scaffolds. Transplantation of those cells, which can be obtained from an easily accessible tissue resource and expanded in vitro, holds promise as a therapeutic approach for reconstruction of tissues and bone in vivo.
Cloning and Characterization of a Novel Kruppel-associated Box Family Transcriptional Repressor That Interacts with the Retinoblastoma Gene Product, RB (2000)

The retinoblastoma gene product, RB, seems to function as a key tumor suppressor by repressing the expression of genes activated by members of the E2F family of transcription factors. In order to accomplish this, RB has been proposed to interact with a transcriptional repressor. However, no genuine transcriptional repressors have been identified by virtue of interaction with RB. By using the yeast two-hybrid system, we have identified a novel member of a known family of transcriptional repressors that contain zinc fingers of the Kruppel type and a portable transcriptional repressor motif known as the Kruppel-associated box (KRAB). The mouse and human forms of the novel RB-associated KRAB protein (RBaK) are widely expressed. The amino acid motif that links the KRAB domain and zinc fingers appears to be required for interaction with RB in vitro. Human RBaK ectopically expressed in fibroblasts is an 80-kDa protein that is localized to the nucleus. The expression of either RB or RBaK in 10T1/2 fibroblasts represses the activation of an E2F-dependent promoter and decreases DNA synthesis to a similar degree. However, a mutant form of RBaK that cannot interact with RB in vitro is unable to prevent DNA synthesis. We present a model in which RB physically interacts with the novel transcriptional repressor RBaK to repress E2F-dependent genes and prevent DNA synthesis.
Physical properties of the quaternary yttrium barium copper oxide superconductor (YBa2Cu3O7) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhysical properties of the quaternary yttrium barium copper oxide superconductor (YBa2Cu3O7)Gary F. Holland and Angelica M. StacyCite this: Acc. Chem. Res. 1988, 21, 1, 8–15Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ar00145a002https://doi.org/10.1021/ar00145a002research-articleACS PublicationsRequest reuse permissionsArticle Views1058Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Low Cost Visual Hull based Markerless System for the Optimization of Athletic Techniques in Outdoor Environments (2013)

We propose a low cost 3D markerless motion analysis system for the optimization of athletic performance during training sessions. The system utilizes eight calibrated and synchronized High Definition (HD) cameras in order to capture a video of an athlete from different viewpoints. An improved kernel density estimation (KDE) based background segmentation algorithm is proposed to segment the athlete’s silhouettes from their background in each video frame. The silhouettes are then reprojected to reconstruct the 3D visual hull (VH) of the athlete. The center of the VH as an approximate representation of the body center of mass is then tracked over a number of frames. A set of motion analysis parameters are finally estimated and compared to the ones obtained by an outdoor state of the art marker-based system (Vicon). The proposed system is aimed at sports such as javelin, pole vault, and long jump and was able to provide comparable results with the Vicon system.
Anti‐tumor efficacy of an anti‐epidermal‐growth‐factor‐ receptor monoclonal antibody and its F(ab′)<sub>2</sub> fragment against high‐ and low‐egfr‐expressing carcinomas in nude mice (1995)

Monoclonal antibody (MAb) MINT5 specifically detects the epidermal-growth-factor receptor (EGFR). In vitro analyses of intact MINT5 (IgG1) and its F(ab')2 fragment indicated that both forms of the MAb inhibited binding of 125I-mEGF to EGFR, induced receptor internalization and blocked EGF-induced EGFR tyrosine-kinase activation in A431 cells. Both forms of the MAb also inhibited to the same extent the proliferation of the carcinoma cell lines A431 and IGROVI, despite the difference in EGFR levels on the cells. The detection of TGF alpha mRNA and the inhibition of cell growth in EGF-free conditions by anti-EGFR MAb indicated the involvement of an EGFR/TGF alpha autocrine/paracrine pathway in the in vitro growth of both cell lines. Analysis of mice xenotransplanted s.c. with A431 cells and treated with MINT5 revealed a block in A431 tumor take in 6 of 10 animals when intact MAb was administered from day 0 to day 11. On a molar basis, F(ab')2 at the same dose was ineffective, although at a 7-fold higher dose F(ab')2 reduced s.c. tumor growth by 80%. At the same dose, intact MINT5 MAb reduced s.c. growth of the EGFR-negative MeWo cell line by 5%. Survival of mice bearing IGROVI i.p. xenotransplants and treated locally with either form of MAb was significantly prolonged even when treatment was initiated on day 3. Corrected doses of intact and F(ab')2 fragment, which accounted for the difference in serum half-lives of the MAb forms, resulted in similar survival rates in the tumor-bearing mice. These pre-clinical results suggest that MINT5 MAb might be safely used for systemic therapy of EGFR-over-expressing tumors. Loco-regional therapy might be contemplated in the case of tumors with moderate/low EGFR expression.
Search as News Curator (2019)

This paper presents an algorithm audit of the Google Top Stories box, a prominent component of search engine results and powerful driver of traffic to news publishers. As such, it is important in shaping user attention towards news outlets and topics. By analyzing the number of appearances of news article links we contribute a series of novel analyses that provide an in-depth characterization of news source diversity and its implications for attention via Google search. We present results indicating a considerable degree of source concentration (with variation among search terms), a slight exaggeration in the ideological skew of news in comparison to a baseline, and a quantification of how the presentation of items translates into traffic and attention for publishers. We contribute insights that underscore the power that Google wields in exposing users to diverse news information, and raise important questions and opportunities for future work on algorithmic news curation.
High Efficiency Finishing of Biomaterial Titanium Alloy by Wide-area Electron Beam Irradiation (2004)

A new surface finishing process for biomaterial titanium alloy products by wide-area electron beam irradiation is proposed. In the wide-area EB irradiation equipment, high energy density EB can be irradiated without concentrating the beam. Therefore, wide-area EB with a maximum diameter of 60mm can be used for instantaneous melting or evaporating metal surface. Experimental results made it clear that the surface roughness becomes smaller and the glossiness becomes higher with increasing energy density of beam. Under a proper irradiating condition, the surface roughness of titanium alloy machined with end mill could be decreased from lOumRz to less than lumRz in just a few minutes. Moreover, the corrosion resistance could be improved simultaneously. Therefore, wide-area EB irradiation method has a possibility of high efficient surface smoothing and surface modification process instead of hand finishing.
The measurement of the fluorescence detected circular dichroism (FDCD) from a chiral Eu(iii) system (2005)

The first measurement of the fluorescence detected circular dichroism (FDCD) from a chiral Eu(III) system, made possible by use of a variable liquid crystal circular polarizer, is reported.
Production of Anthocyanins, Carotenoids, and Proanthocyanidins by Cultured Cells of Rabbiteye Blueberry (<i>Vaccinium ashei</i>Reade) (1993)

Two types of cell lines, a red-cell predominant line and a yellow-cell predominant one, were selected from secondary callus of rabbiteye blueberry (Vaccinium ashei Reade) leaf, and subcultured in the light and in the dark, respectively. Cultures of the red-cell line produced anthocyanins and the composition was simple as compared with that of the parent plant. The yellow-cell line produced carotenoids which had a visible absorption spectrum similar to that of neochrome. Both cell lines produced proanthocyanidins at the same levels. Proanthocyanidins were detected as red pigment (anthocyanidins) upon incubation of cells with 1% HCI-methanol at 50°C for 18 h. Composition of the, anthocyanidins was simple as compared with that of those formed from proanthocyanidins in leaves during incubation. The anthocyanidins showed a retention time very closely related to that of authentic cyanidin by high performance liquid chromatography and comprised about 64% of the total peak area. Amounts of anthocyanins and proanthocyanidins (as anthocyanidins) in cultured cells didn't exceed those in the parent plant.
High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma (2006)

The tumor microenvironment plays an important role in the biologic behavior of follicular lymphoma (FL), but the specific cell subsets involved in this regulation are unknown. To determine the impact of FOXP3-positive regulatory T cells (Tregs) in the progression and outcome of FL patients, we examined samples from 97 patients at diagnosis and 37 at first relapse with an anti-FOXP3 monoclonal antibody. Tregs were quantified using computerized image analysis. The median overall survival (OS) of the series was 9.9 years, and the FL International Prognostic Index (FLIPI) was prognostically significant. The median Treg percentage at diagnosis was 10.5%. Overall, 49 patients had more than 10% Tregs, 30 between 5% to 10%, and 19 less than 5%, with a 5-year OS of 80%, 74%, and 50%, respectively (P = .001). Patients with very low numbers of Tregs (< 5%) presented more frequently with refractory disease (P = .007). The prognostic significance of Treg numbers was independent of the FLIPI. Seven transformed diffuse large B-cell lymphomas (DLBCLs) had lower Treg percentages (mean: 3.3%) than FL grades 1,2 (mean: 12.1%) or 3 (mean: 9%) (P < .02). In conclusion, high Treg numbers predict improved survival of FL patients, while a marked reduction in Tregs is observed on transformation to DLBCL.
MEIOTIC IRREGULARITY IN SPECIES AND INTERSPECIFIC HYBRIDS OF PINUS (1966)

This paper describes a comparative analysis of meiotic conditions in 61 individual trees representing 21 species and 22 interspecific hybrid combinations of the genus Pinus . Material was collected during three successive growing seasons at the Eddy Arboretum of the Institute of Forest Genetics at Placerville, California. Meiotic irregularity occurred in all species and hybrids examined; mean irregularity frequencies of individual trees ranged from 0 to 47.2 percent. Abnormalities in chromosome movement and their consequences, (1) precocious disjunction associated with the occurrence of univalents and (2) the failure of chiasma terminalization leading to lagging chromosomes and to chromosome breakage and fragments, account for most of the observed irregularity. The same kinds of irregularity occur both in the species and in the hybrids, but they were considerably more frequent in certain of the hybrids than in the related species. These abnormalities in chromosome movement seem to be characteristic of Pinus and are attributed primarily to rrechanical difficulties which attend the large pine chromosomes in meiosis. The most spectacular meiotic irregularities were the characteristic bridge‐fragment configurations considered to be the result of crossing‐over in heterozygous paracentric inversions. Inversion bridges were observed in 59 of the 61 trees and were as frequent in the species as in the hybrids. They apparently do not result from interspecific differentiation in chromosome structure but from spontaneous intra‐specific rearrangements. The literature and work now in progress provide increasing evidence that introgression has been an important factor in the evolution of pine populations. The cytological study of pine chromosomes has failed to produce qualitative evidence of introgression, but the quantitative measurement of meiotic irregularity may serve as a useful criterion for recognizing the results of past hybridization.
Current Status of Sentinel Lymph Node Surgery for Breast Cancer (1999)

The purpose of this review is to critically evaluate the collective epidemiologic evidence that a history of breastfeeding may decrease the risk of breast cancer. Original data for inclusion were identified through a MEDLINE search of the English language literature from 1966 through 1998. To date, virtually all epidemiologic data regarding breastfeeding and breast cancer risk are derived from case-control studies, which vary according to classification of breastfeeding history. Overall, the evidence with respect to "ever" breast-feeding remains inconclusive, with results indicating either no association or a rather weak protective effect against breast cancer. An inverse association between increasing cumulative duration of breast-feeding and breast cancer risk among parous women has been reported in some, but not all, studies; the failure to detect an association in some Western populations may be due to the low prevalence of prolonged breast-feeding. It appears that the protective effect, if any, of long-term breast-feeding is stronger among, or confined to, premenopausal women. It has been hypothesized that an apparently protective effect of breast-feeding may be due to elevated breast cancer risk among women who discontinue breast-feeding or who take medication to suppress lactation; however, the evidence is limited and should be interpreted with caution. The biology underlying a protective effect of breast-feeding and why this should be restricted to premenopausal women remain unknown, although several mechanisms have been postulated (hormonal changes, such as reduced estrogen; removal of estrogens through breast fluid; excretion of carcinogens from breast tissue through breast-feeding; physical changes in the mammary epithelial cells, reflecting maximal differentiation; and delay of the re-establishment of ovulation). While breastfeeding is a potentially modifiable behavior, the practical implication of reduced breast cancer risk among premenopausal women with prolonged durations of breast-feeding may be of marginal importance, particularly in Western societies. [
Hypermethylation of the somatostatin promoter is a common, early event in human esophageal carcinogenesis (2007)

SST promoter hypermethylation is a common event in human esophageal carcinomas and is related to early neoplastic progression in Barrett esophagus.