gebhart/patrepeval huggingface dataset:
Identification of Human MHC Class I Binding Peptides using the iTOPIA™− Epitope Discovery System (2009)

CD8+ T cells recognize antigenic peptides presented in the context of MHC class I. They play a key role in cellular immunity and are crucial for longterm protective immunity to many infectious diseases. The quest for new and enhanced vaccines requires improved means for identification of relevant antigens and the epitopes present within these. While there are several algorithms available for epitope prediction (all of which work to differing degrees of success), the definition of actual MHC class I-binding epitopes is very reliant on time-consuming and difficult to perform functional assays using often very limited biological material. The iTOPIA assay is quick and easy to perform and determines real-binding to MHC class I molecules. It provides an excellent platform for screening and elimination of potential epitopes and identification of novel epitopes prior to validation with a relevant functional assay.
Ontology based automatic speech recognition and generation for human-agent interaction (2005)

In this paper, we present a system that support an automatic speech recognition and generation between users and an agent based application on the basis of the ontologies used in the application domain. The system is realized taking advantage of the JADE agent development framework and of the IBM Via Voice Tool and has been experimented in different applications fields testing agent-user interaction both in Italian and English. In particular, the paper introduces a short description of the use of the system for banking applications.
Thymidine and deoxyuridine accumulate in tissues of patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) (2007)

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disease due to ECGF1 gene mutations causing thymidine phosphorylase (TP) deficiency. Analysis of post-mortem samples of five MNGIE patients and two controls, revealed TP activity in all control tissues, but not in MNGIE samples. Converse to TP activity, thymidine and deoxyuridine were absent in control samples, but present in all tissues of MNGIE patients. Concentrations of both nucleosides in the tissues were generally higher than those observed in plasma of MNGIE patients. Our observations indicate that in the absence of TP activity, tissues accumulate nucleosides, which are excreted into plasma.
Columns for Modern Analytical Liquid Chromatography (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTColumns for Modern Analytical Liquid ChromatographyJ. J. KIRKLANDCite this: Anal. Chem. 1971, 43, 12, 36A–48APublication Date (Print):October 1, 1971Publication History Published online23 May 2012Published inissue 1 October 1971https://pubs.acs.org/doi/10.1021/ac60306a704https://doi.org/10.1021/ac60306a704research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterization of Health-Related Quality of Life in Heart Failure Patients with Preserved Versus Low Ejection Fraction in CHARM (2006)

In symptomatic HF patients, HRQL is equally impaired in both preserved and low LVEF populations. Targeting improvement in symptoms and HRQL is an important treatment objective in all HF patients.
Safety, pharmacokinetics, and preliminary activity of the α-specific PI3K inhibitor BYL719: Results from the first-in-human study. (2013)

2531 Background: BYL719 is an oral small-molecule inhibitor of the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K), which is encoded by the PIK3CA gene, one of the most commonly mutated genes in human cancers. BYL719 inhibits proliferation of PI3Kα-driven cancer cell lines in vitro and causes regression of PIK3CA-mutant tumor models in vivo. Methods: This Ph I study was performed in patients (pts) with advanced solid tumors carrying a somatic mutation of PIK3CA. Dose escalation used an adaptive Bayesian logistic regression model with overdose control. Following determination of the maximum tolerated dose (MTD), an expansion cohort was opened at the MTD to evaluate safety, pharmacokinetics (PK), and clinical activity in pts with PIK3CA-mutant advanced solid tumors, including estrogen receptor-positive (ER+) metastatic breast cancer (mBC). Results: During dose escalation 36 pts received doses up to 450 mg/d, where 4/9 pts had dose-limiting toxicities (DLTs). The MTD for once-daily dosing was declared as 400 mg/d. As of Nov 20 2012, DLTs were hyperglycemia, nausea, vomiting, and diarrhea. The most common BYL719-related adverse events (all grades, all cohorts, >25%) were hyperglycemia (49%), nausea (45%), diarrhea (40%), decreased appetite (38%), vomiting (30%), and fatigue (27%). 39 pts are enrolled in the MTD dose-expansion cohort. Investigation of a twice-daily regimen is also ongoing. BYL719 has a favorable, approximately dose-proportional PK profile with a T max of 2h and a T ½ of 11h at the MTD. Partial responses were seen in 7 pts (in ER+ breast [2], cervical, trichilemmal, endometrial, ovarian, and head &neck cancer [1 each]); 17 pts stayed on study for >24 weeks. For 67 pts (76%) treated at doses of ≥270 mg/d, the median progression-free survival (mPFS) was 3.6 months (mo; 95% CI: 3.5–5.5 mo). mPFS in 15 ER+ HER2– mBC pts treated at ≥270 mg/d was 5.5 mo (95% CI: 3–7 mo). Conclusions: BYL719 displays dose-proportional and predictable PK. The safety profile is favorable, with mostly manageable on-target toxicities. At doses of ≥270 mg/d, tumor regression and prolonged disease control were observed in heavily pretreated pts with various tumor types carrying a PIK3CA mutation. Clinical trial information: NCT01219699.
Development of smartphone-based public vigilance systems (2008)

We present several implementations of public information collection systems. September 11th tragedy, acts of mass terrorism like DC sniper case, and suicide bombings in Europe force authorities to seek the most effective surveillance technique. It is common consensus that a common bystander does see the potentially dangerous events unwrap, and making it possible for him to notify the appropriate personal about his observations is vital to the public safety and the structural integrity of the municipal property. Cell phones are ubiquitous and most of them are equipped with a camera. The paper presents applications, both client-side and server-side, that handle the notification process. It makes it convenient and reliable.
Elevated Serum Titers of Proinflammatory Cytokines and CNS Autoantibodies in Patients with Chronic Spinal Cord Injury (2002)

This study characterized the proinflammatory cytokines, interleukin-2 (IL-2) and tumor necrosis factor alpha (TNFalpha), the antiinflammatory cytokines, IL-4 and IL-10, autoantibodies specific for GM1 ganglioside (anti-GM1), IgG and IgM, and myelin-associated glycoprotein (anti-MAG), in the sera of infection-free, chronic (>12 months), traumatically injured SCI patients (n = 24). Healthy able-bodied subjects (n = 26) served as controls. The proinflammatory cytokines and anti-GM1 antibodies were of particular interest as they have been implicated in an autoimmune "channelopathy" component to central and peripheral conduction deficits in various chronic neuroinflammatory diseases. Antibody and cytokine titers were established using enzyme-linked immunosorbent assays (ELISA). The mean anti-GM(1) (IgM) titer value for the SCI group was significantly higher (p < 0.05) than controls. The SCI group also demonstrated significantly higher titers (p < 0.05) of IL-2 and TNF alpha than controls. No differences were found between the SCI group and control group mean levels of IL-4 or IL-10. Overall, the serum of 57% of SCI patients contained increased levels of autoantibodies or proinflammatory cytokines relative to control values. These results provide preliminary support for the hypothesis that chronic immunological activation in the periphery occurs in a subpopulation of chronic SCI patients. It remains to be established whether elevated serum titers of proinflammatory cytokines and autoantibodies against GM1 are beneficial to the patients or whether they are surrogate markers of a channelopathy that compounds the neurological impairment associated with traumatic axonopathy or myelinopathy.
Mechanical Testing Methodology for Ceramic Design and Reliability (1998)

Describing the theoretical aspects of chemistry and microstructure that affect mechanical properties, this work offers coverage of ceramic mechanical property measurement techniques for use in component design as well as lifetime and reliability predictions. It presents procedures from both room- and elevated-temperature applications.
STRUCTURE-PRESERVING ALGORITHMS FOR DYNAMICAL SYSTEMS (2002)

We study structure-preserving algorithms to phase space volume for linear dynamical systems y = Ly for which arbitrarily high order explicit symmetric structure-preserving schemes,i.e. the numerical solutions generated by the schemes satisfy det( ) =ehtrL, where trL is the trace of matrix L, can be constructed. For nonlinear dynamical systems y = f(y) Feng-Shang first-order volume-preserving scheme can be also constructed starting from modified θ- methods and is shown that the scheme is structure-preserving to phase space volume.
Beta(3) integrin expression increases breast carcinoma cell responsiveness to the malignancy-enhancing effects of osteopontin. (2003)

Osteopontin (OPN) is a secreted phosphoprotein that has been associated with malignancy of breast and other cancers. OPN binds to several cell surface integrins including alpha(v)beta(3), alpha(v)beta(5), and alpha(v)beta(1). Although the relative contribution of these integrins to breast cancer cell malignancy is uncertain, correlative studies suggest that alpha(v)beta(3) may be particularly associated with increased tumor aggressiveness. Previously, we reported that tumorigenic, nonmetastatic 21NT mammary carcinoma cells respond to OPN through alpha(v)beta(5) and alpha(v)beta(1) but not alpha(v)beta(3). Here, we determined that 21NT cells lack beta(3) expression, and we asked whether expression of alpha(v)beta(3) could enhance the ability of breast cancer cells to respond to the malignancy-promoting effects of OPN both in vitro and in vivo. 21NT cells stably transfected with beta(3) showed significantly increased adhesion, migration, and invasion to OPN in vitro compared with vector control. To determine if beta(3) could also enhance the response of breast epithelial cells to OPN in vivo, cells stably transfected with both beta(3) and OPN (NT/Obeta(3)) were injected into the mammary fat pad of female nude mice and primary tumor growth was assessed relative to controls. Mice injected with NT/Obeta(3) cells demonstrated a significantly increased primary tumor take (75% of mice) compared with controls (0-12.5% of mice) as well as a decreased tumor doubling time and a decreased tumor latency period. These results suggest that increased expression of the alpha(v)beta(3) integrin during breast cancer progression can make tumor cells more responsive to malignancy-promoting ligands such as OPN and result in increased tumor cell aggressiveness.
Spectral Karyotyping Analysis of Head and Neck Squamous Cell Carcinoma (2001)

Spectral karyotyping analysis reveals the true complexity of chromosomal aberrations in cell lines derived from head and neck squamous cell carcinomas. The use of SKY, in combination with other techniques, may allow for a more complete assessment of the genetic abnormalities of head and neck cancers and serve as a starting point for gene identification.
Nitrous oxide production by Alcaligenes faecalis under transient and dynamic aerobic and anaerobic conditions (1996)

Nitrous oxide can be a harmful by-product in nitrogen removal from wastewater. Since wastewater treatment systems operate under different aeration regimens, the influence of different oxygen concentrations and oxygen fluctuations on denitrification was studied. Continuous cultures of Alcaligenes faecalis TUD produced N2O under anaerobic as well as aerobic conditions. Below a dissolved oxygen concentration of 5% air saturation, the relatively highest N2O production was observed. Under these conditions, significant activities of nitrite reductase could be measured. After transition from aerobic to anaerobic conditions, there was insufficient nitrite reductase present to sustain growth and the culture began to wash out. After 20 h, nitrite reductase became detectable and the culture started to recover. Nitrous oxide reductase became measurable only after 27 h, suggesting sequential induction of the denitrification reductases, causing the transient accumulation of N2O. After transition from anaerobic conditions to aerobic conditions, nitrite reduction continued (at a lower rate) for several hours. N2O reduction appeared to stop immediately after the switch, indicating inhibition of nitrous oxide reductase, resulting in high N2O emissions (maximum, 1.4 mmol liter-1 h-1). The nitrite reductase was not inactivated by oxygen, but its synthesis was repressed. A half-life of 16 to 22 h for nitrite reductase under these conditions was calculated. In a dynamic aerobic-anaerobic culture of A. faecalis, a semisteady state in which most of the N2O production took place after the transition from anaerobic to aerobic conditions was obtained. The nitrite consumption rate in this culture was equal to that in an anaerobic culture (0.95 and 0.92 mmol liter-1 h-1, respectively), but the production of N2O was higher in the dynamic culture (28 and 26% of nitrite consumption, respectively).
Anion Effects on Solid Polymer Electrolytes Containing Sulfur Based Ionic Liquid for Lithium Batteries (2012)

Solid polymer electrolytes for lithium batteries possess increased safety over traditional carbonate electrolytes, but have not been shown effective at temperatures close to ambient. The inclusion of triethyl sulfonium based ionic liquids (IL) into poly(ethylene oxide) (PEO) homopolymers has demonstrated the ability to reach the necessary figures of merit for use in a lithium battery below physiological temperature. The effect of the anion for the IL and the lithium salt was measured for bis(perfluoroethylsulfonyl) imide, bis(oxalato) borate, perchlorate, hexafluorophosphate (PF6) and bis(trifluorosulfonyl) imide (TFSI), and all showed ionic conductivity on the order of 1 mS/cm at physiological temperature. TLi+ ranged from 0.19–0.31 for the systems and some anions demonstrated stability exceeding 5 V vs. Li/Li+. The ability to reversibly plate and strip lithium was also measured and was largely influenced by the resistance of the electrolyte-electrode interface. This research demonstrated that TFSI is the best choice of anions for the solid polymer electrolyte system, while PF6 is the worst. The other anions demonstrated a range of properties that depending on the needed properties could potentially be favored relative to TFSI.
A Novel Active Filter for Mitigation of EMI and Other Adverse Effects of PWM Inverter-Fed AC Motor (2009)

This paper presents novel active filter for mitigation electromagnetic interference (EMI) and other adverse effects of pulse width modulation (PWM) inverter-fed AC motor system. An active filter proposed and devised for this system is characterized by sophisticated connection of two small separate filters, capable of mitigating all the adverse effects. This paper provides high frequency models of PWM inverter, rectifier, DC link, induction motor and long cable. The configuration and design procedure of the proposed filter is presented. The whole system is modeled and simulated by commercially available simulation software. A practical system with EMI measurement system have been suggested to test designed equipment ability in emitting EMI and other adverse effects to comply with electromagnetic compatibility (EMC) standards. The simulation results are verified by experimental results, which show the reduction characteristics of the shaft voltage, bearing current, common mode current, leakage current and EMI.
The Efficacy of Emphasizing a Legal System Approach to Computer Security (2006)

Computer security is increasingly relying on legal remedies. But is the legal system capable and ready to handle the complexities of security issues? This study surveys various members of legal institutions to identify readiness and potential shortcomings that need to be addressed to make the legal system an effective component of computer security.
Hyphal Elongation of <i>Glomus fasciculatus</i> in Response to Root Exudates (1987)

The spore germination rates on water agar of the vesicular-arbuscular mycorrhizal fungus Glomus fasciculatus were highest at water potentials of −4 to −6 bars. Root exudates from plants grown in a sterile nutrient solution, with or without phosphorus, did not affect germination. Root exudates collected from 2-, 4-, and 6-week-old Trifolium repens cv. `Ladino' seedlings that were deprived of P enabled hyphal growth from germinated Glomus fasciculatus spores of 21.4, 14.7, and 7.6 mm, respectively. Hyphal elongation in the presence of exudates from plants grown with P, or in the absence of exudates, was negligible (<1 mm). Root P at 2 weeks was not significantly different between plants grown with and without P. There were no significant differences between the quantities of exudates from plants grown with or without P at 2, 4, and 6 weeks. The data suggest that it is the quality of exudates from plants experiencing P deprivation that is important in stimulating vesicular-arbuscular mycorrhizal hyphal elongation.
Privacy Requirements: Present & Future (2017)

Software systems are increasingly open, handle large amounts of personal or other sensitive data and are intricately linked with the daily lives of individuals and communities. This poses a range of privacy requirements. Such privacy requirements are typically treated as instances of requirements pertaining to compliance, traceability, access control, verification or usability. Though important, such approaches assume that the scope for the privacy requirements can be established a priori and that such scope does not vary drastically once the system is deployed. User data and information, however, exists in an open, hyper-connected and potentially "unbounded" environment. Furthermore, "privacy requirements - present"and "privacy requirements - future" may differ significantly as the privacy implications are often emergent a posteriori. Effective treatment of privacy requirements, therefore, requires techniques and approaches that fit with the inherent openness and fluidity of the environment through which user data and information flows. This paper surveys state of the art and presents some potential directions in the way privacy requirements should be treated. We reflect on the limitations of existing approaches with regards to unbounded privacy requirements and highlight a set of key challenges for requirements engineering research with regards to managing privacy in such unbounded settings.
Design and Field Testing of Manufacturable Advanced Low-Cost Receiver for Parabolic Trough Solar Power (2019)

This project addresses the 30-yr service life, ease of manufacturability for low cost, and low Operations and Maintenance (O&M) costs for our novel parabolic trough receiver, SunTrap. Current trough-based commercial power plants operate at 400°C or below, in part due to poor performance and lifetime of existing receivers at higher temperatures. Thermal losses from such receivers are dominated by radiation; by the Stefan- Boltzmann law, radiative losses have a component that scales as T4, challenging high-temperature efficiency. Our novel SunTrap receiver offers increased reliability by eliminating the need to operate in a vacuum, while improving performance at higher temperatures by using high-performance insulation on exposed sections of the receiver that absorb negligible solar flux. As a result, SunTrap offers comparable optical efficiency to currently available technology while reducing thermal losses at higher temperatures. In this project, our novel receiver and all subcomponents have been designed to be compatible with molten salts to enable operation at next generation trough-based exit temperatures between 500 and 550°C. Norwich Technologies, with collaborators from Creare, Thermodyne, Solar Dynamics (previously Abengoa Solar), and the University of Louisiana – Lafayette successfully iterated the design of the SunTrap receiver through a series of modelling efforts, cost analyses, prototype builds, and performance and lifetime tests to minimize the levelized cost of energy (LCOE). The final design (1) realized predicted receiver performance in a series of field optical efficiency, laboratory thermal efficiency and freeze/thaw recovery tests, (2) optimized the receiver with respect to integration with standard collector systems, receiver-to-receiver connections, and receiver-to-mirror connections, (3) demonstrated 30-yr service life of receiver and all components of the receiver, (4) developed commercialization and manufacturing plans to enable rapid deployment, and (5) demonstrated durability of an air-stable solar-selective coating. NT’s disruptive technology marshals diverse advances in design, materials and coatings to revolutionize key aspects of the CSP trough solar field. By enabling significant operational and cost advances, this technology offers potential decreases in LCOE of over 20% compared to traditional parabolic trough systems.
Advanced coordination between a traffic control center and its supporting units (2002)

This paper describes a new Central Traffic Control System (CTCS), implemented in several sites in Europe, and also in Haifa, Israel. The CTCS implemented in Haifa contains enhanced capabilities. While it incorporates the general philosophy of on- and off-line traffic signalization control, the CTCS also coordinates its control strategies with supporting units, namely, electronic signs for drivers, closed-circuit TV system, priority for transit vehicles, and for emergency vehicles. In addition, this CTCS allows for coordination with advanced optimization software aimed at optimal online traffic signalization control, for both congested and uncongested traffic flow situations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>