gebhart/patrepeval huggingface dataset:
Range requirements in radar cross-section measurements (1965)

The conditions for radar cross-section measurement are given in terms of permissible variations in the amplitude and phase of the incident field at the target. A number of minimum range conditions are listed and discussed. The minimum range associated with the uniform square aperture antenna is analyzed and its relationship to the sensitivity of measurement is determined. Measurements of small targets in the near zones of focused and unfocused apertures are examined. The substantial range reduction possible with the use of a suitable microwave lens, when measuring large and medium size targets, is indicated.
Optimization with constraints, 2nd ed. (2025)

Let c i be an inequality constraint.Assume that c i is concave on IR n .If c i (x) 0, c i (y) 0 and [0, 1], then Definition 1.14 implies thatThus, the set of points where c i is satisfied is a convex set.This means that the feasible domain P is convex if all equality constraints are linear and all inequality constraints are concave.
A continuous-time ripple reduction technique for spinning-current Hall sensors (2013)

The intrinsic offset of Hall sensors can be reduced with the help of the spinning-current technique, which modulates this offset away from the signal band. The resulting offset ripple can then be removed by a low-pass filter, which, however, limits the sensor's bandwidth. This paper presents a ripple-reduction technique that does not require a low-pass filter. Measurements on a Hall sensor system implemented in a 0.18µm CMOS process show that the technique can reduce the residual ripple by at least 40dB - to the same level as the sensor's noise.
A brief history of the development of sound intensity measurement (2010)

The advent of instruments capable of measuring sound intensity, which represents the flow of energy in sound fields, has revolutionised audio-frequency acoustical metrology. Since publication of the first edition, two International Standards for the use of sound intensity for sound source power determination, and one International Standard for sound intensity instrumentation, have also been published. A number of International Standards have also been developed.
Sensitivity of 2DEG-based Hall-effect sensors at high temperatures (2020)

The magnetic sensitivity of Hall-effect sensors made of InAlN/GaN and AlGaN/GaN heterostructures was measured between room temperature and 576 °C. Both devices showed decreasing voltage-scaled magnetic sensitivity at high temperatures, declining from 53 mV/V/T to 8.3 mV/V/T for the InAlN/GaN sample and from 89 mV/V/T to 8.5 mV/V/T for the AlGaN/GaN sample, corresponding to the decreasing electron mobility due to scattering effects at elevated temperatures. Alternatively, current-scaled sensitivities remained stable over the temperature range, only varying by 13.1% from the mean of 26.3 V/A/T and 10.5% from the mean of 60.2 V/A/T for the InAlN/GaN and AlGaN/GaN samples, respectively. This is due to the minimal temperature dependence of the electron sheet density on the 2-dimensional electron gas (2DEG). Both devices showed consistency in their voltage- and current-scaled sensitivity over multiple temperature cycles as well as nearly full recovery when returned to room temperature after thermal cycling. Additionally, an AlGaN/GaN sample held at 576 °C for 12 h also showed nearly full recovery at room temperature, further suggesting that GaN-based Hall-effect sensors are a good candidate for use in high temperature applications.
Use of Ketoconazole in the Treatment of Cushing’s Syndrome (1986)

The therapeutic value of ketoconazole for long term treatment of patients with Cushing's syndrome was studied. Seven patients with Cushing's disease and one with an adrenal adenoma received 600-800 mg/day ketoconazole for 3-13 months. Plasma ACTH, cortisol, and dehydroepiandrosterone sulfate levels and urinary cortisol, 17-ketosteroid, and tetrahydro-11-deoxycortisol excretion were determined periodically during the treatment period. Plasma ACTH and cortisol responses to CRH stimulation were determined before and during treatment. Rapid and subsequently persistent clinical improvement occurred in each patient; plasma dehydroepiandrosterone sulfate and urinary 17-ketosteroid and cortisol excretion decreased soon after the initiation of treatment, subsequently remaining normal or nearly so throughout the treatment period. Urinary tetrahydro-11-deoxycortisol excretion increased significantly. Plasma cortisol levels decreased. Plasma ACTH levels did not change, and individual plasma ACTH and cortisol increments in response to CRH were comparable before and during treatment. The cortisol response to insulin-induced hypoglycemia improved in one patient and was restored to normal in another. The seven patients tested recovered normal adrenal suppressibility in response to a low dose of dexamethasone during ketoconazole treatment. Ketoconazole is effective for long term control of hypercortisolism of either pituitary or adrenal origin. Its effect appears to be mediated by inhibition of adrenal 11 beta-hydroxylase and 17,20-lyase, and it, in some unknown way, prevents the expected rise in ACTH secretion in patients with Cushing's disease.
InP monolithically integrated coherent transmitter (2015)

A novel InP monolithically integrated coherent transmitter has been designed, fabricated and tested. The photonic integrated circuit consists of a distributed Bragg reflector laser and a modified nested Mach-Zehnder modulator having tunable input power splitters. Back-to-back coherent transmission for PDM-QPSK signals is reported up to 10 Gbaud (40 Gb/s) using the integrated laser and up to 32Gbaud (128 Gb/s) using an external low phase noise laser.
The chemotherapy of rodent malaria. XLIX. The activities of some synthetic 1,2,4-trioxanes against chloroquine-sensitive and chloroquine-resistant parasites. Part 2: Structure-activity studies on <i>cis</i> -fused cyclopenteno-1,2,4-trioxanes (fenozans) against drug-sensitive and drug-resistant lines of <i>Plasmodium berghei</i> and <i>P.yoelii</i> ssp. NS <i>in vivo</i> * (1993)

The activity of 51 synthetic cis-fused cyclopenteno-1,2,4-trioxanes has been examined against drug-sensitive and chloroquine-resistant malaria parasites in vivo. Some of them display high levels of blood schizontocidal activity when administered orally or subcutaneously. They retain their activity against lines of parasites that are resistant to widely differing antimalarials such as 4-aminoquinolines, aminoalcohols, dihydrofolate reductase inhibitors and artemisinin. The most potent compound of the present series is cis-(+/-)-4a,7a-dihydro-6,7a-di(p-fluorophenyl)spiro [cyclopentane-3,3'-7H-cyclopenta-1,2,4-trioxin], otherwise known as Fenozan-50F.
Biosynthesis of Anisotropic Silver Nanoparticles by <i>Bhargavaea indica</i> and Their Synergistic Effect with Antibiotics against Pathogenic Microorganisms (2015)

The strain Bhargavaea indica DC1 isolated from four‐year‐old P. ginseng rhizospheric soil was used to perform rapid and extracellular biosynthesis of anisotropic silver nanoparticles. The ultraviolet‐visible (UV‐vis) spectra of the reaction mixture containing silver nanoparticles showed a peak at 460 nm, corresponding to the surface plasmon absorbance of silver nanoparticles. Field‐emission transmission electron microscopy (FE‐TEM) structural characterization revealed the nanobar, pentagon, spherical, icosahedron, hexagonal, truncated triangle, and triangular nanoparticles, with the size range from 30 to 100 nm. The energy‐dispersive X‐ray (EDX) analysis and elemental mapping results also confirmed that the silver was the predominant component of isolated nanoparticles. The X‐ray diffraction (XRD) results correspond to the purity of silver nanoparticles and dynamic light scattering (DLS) result indicated that the average diameter of particles was 111.6 nm. In addition, enhancement in antimicrobial activity of commercial antibiotics was observed against various pathogenic microorganisms such as Vibrio parahaemolyticus, Salmonella enterica, Staphylococcus aureus, Bacillus anthracis, Bacillus cereus, Escherichia coli , and Candida albicans .
CRYSTALLIZABLE POLYSTYRENE (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCRYSTALLIZABLE POLYSTYRENEJack L. R. Williams, John Van Den Berghe, William J. Dulmage, and Kenneth R. DunhamCite this: J. Am. Chem. Soc. 1956, 78, 6, 1260Publication Date (Print):March 1, 1956Publication History Published online1 May 2002Published inissue 1 March 1956https://pubs.acs.org/doi/10.1021/ja01587a051https://doi.org/10.1021/ja01587a051research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification of Amino Acid Residues in APOBEC3G Required for Regulation by Human Immunodeficiency Virus Type 1 Vif and Virion Encapsidation (2007)

The human immunodeficiency virus type-1 (HIV-1) accessory protein Vif serves to neutralize the human antiviral proteins apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G [A3G]) and A3F. As such, the therapeutic blockade of Vif function represents a logical objective for rational drug design. To facilitate such endeavors, we have employed molecular genetics to define features of A3G that are required for its interaction with Vif. Using alanine-scanning mutations and multiple different substitutions at key residues, we confirm the central role played by the aspartic acid at position 128 and identify proline 129 and aspartic acid 130 as important contributory residues. The overall negative charge of this 3-amino-acid motif appears critical for recognition by Vif, as single lysine substitutions are particularly deleterious and a double alanine substitution at positions 128 and 130 is far more inhibitory than single-residue mutations at either position. Our analyses also reveal that the immediately adjacent 4 amino acids, residues 124 to 127, are important for the packaging of A3G into HIV-1 particles. Most important are tyrosine 124 and tryptophan 127, and mutations at these positions can ablate virion incorporation, as well as the capacity to inhibit virus infection. Thus, while pharmacologic agents that target the acidic motif at residues 128 to 130 have the potential to rescue A3G expression by occluding recognition by Vif, care will have to be taken not to perturb the contributions of the neighboring 124-to-127 region to packaging if such agents are to have therapeutic benefit by promoting A3G incorporation into progeny virions.
Sodium Acetate as a Source of Fixed Base. (1949)

SummaryStudies in dogs and in man demonstrate that sodium acetate is an easily prepared and a rapidly available non-toxic source of fixed base suitable for parenteral administration when alkalinization is indicated.
Liquid Hydrogen Bubble Chambers (1955)

Chambers 2½ inches and 4 inches in diameter have been constructed of brass with pyrex ports and sealed with lead-wire gaskets. Metal walls and a copper heat leak eliminate the need for a surrounding pressurized bath. The required fast-pulsing techniques and use of a heat regenerator are described in detail. Schematic diagrams show the chambers, pressure- and temperature-monitoring devices, and illumination method, and photographs of typical tracks and events are included.
SERUM LEVELS OF UNCONJUGATED AETIOCHOLANOLONE, ANDROSTENEDIONE, TESTOSTERONE, DEHYDROEPIANDROSTERONE, ALDOSTERONE, PROGESTERONE AND OESTROGENS DURING THE NORMAL MENSTRUAL CYCLE (1976)

The results of daily determination of the levels of gonadotrophins, oestradiol, oestrone, progesterone, aldosterone, dehydroepiandrosterone, androstenedione, testosterone, and aetiocholanolone in the serum of 6 normal, ovulating women are reported and discussed. A pre-ovulatory aldosterone peak and rising values in the luteal phase of the cycle were found. Androstenedione, testosterone, and aetiocholanolone levels were significantly elevated from 3 days before until 3 days after ovulation. Since the mean androstenedione/aetiocholanolone ratio in the individual cycles in this period was similar to the ratio found during the rest of the cycle, we think it unlikely that aetiocholanolone is produced by the ovaries. No correlation was found between the aetiocholanolone patterns and the basal body temperature. In a case of conception followed for 20 days after ovulation, the steroid patterns remained unchanged until the presumed day of implantation, after which the aldosterone, androstenedione, testosterone, and aetiocholanolone levels started to rise. The mean androstenedione/aetiocholanolone ratio during the 10 days after implantation did not differ from the values obtained in the foregoing periods, so direct aetiocholanolone production by the ovaries after implantation seems unlikely.
An update on current and future treatment options for chondrosarcoma (2019)

<b>Introduction</b>: Human chondrosarcomas (CS; a malignant cartilage-forming bone tumor) respond poorly to chemotherapy and radiation treatment, resulting in high morbidity and mortality rates. Expanded treatment options are urgently needed. <b>Areas covered</b>: This article updates our 2014 review, in which we evaluated the CS treatments available at that time and potential treatment options under investigation. Since then, advances in research findings, particularly from Chinese herbal medicines, may be bringing us closer to more effective therapies for CS. In particular, promising findings have been reported from research targeting platelet-derived growth factor receptor. <b>Expert opinion</b>: Few treatment options exist for CS; chemotherapy is not even an option for unresectable disease, in which 5-year survival rates are just 2%. New information about the multitude of genes and signaling pathways that encourage CS growth, invasion and metastasis are clarifying how certain signaling pathways and plant-derived active compounds, especially molecularly-targeted therapies that inhibit the PDGF receptor, interfering with these biological processes. This review summarizes discoveries from the last 5 years and discusses how these findings are fueling ongoing work into effectively dealing with the disease process and improving the treatment of CS.
Efficacy of Leukadherin-1 in the Prevention of Hyperoxia-Induced Lung Injury in Neonatal Rats (2015)

Lung inflammation plays a key role in the pathogenesis of bronchopulmonary dysplasia (BPD), a chronic lung disease of premature infants. The challenge in BPD management is the lack of effective and safe antiinflammatory agents. Leukadherin-1 (LA1) is a novel agonist of the leukocyte surface integrin CD11b/CD18 that enhances leukocyte adhesion to ligands and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Its functional significance in preventing hyperoxia-induced neonatal lung injury is unknown. We tested the hypothesis that administration of LA1 is beneficial in preventing hyperoxia-induced neonatal lung injury, an experimental model of BPD. Newborn rats were exposed to normoxia (21% O2) or hyperoxia (85% O2) and received twice-daily intraperitoneal injection of LA1 or placebo for 14 days. Hyperoxia exposure in the presence of the placebo resulted in a drastic increase in the influx of neutrophils and macrophages into the alveolar airspaces. This increased leukocyte influx was accompanied by decreased alveolarization and angiogenesis and increased pulmonary vascular remodeling and pulmonary hypertension (PH), the pathological hallmarks of BPD. However, administration of LA1 decreased macrophage infiltration in the lungs during hyperoxia. Furthermore, treatment with LA1 improved alveolarization and angiogenesis and decreased pulmonary vascular remodeling and PH. These data indicate that leukocyte recruitment plays an important role in the experimental model of BPD induced by hyperoxia. Targeting leukocyte trafficking using LA1, an integrin agonist, is beneficial in preventing lung inflammation and protecting alveolar and vascular structures during hyperoxia. Thus, targeting integrin-mediated leukocyte recruitment and inflammation may provide a novel strategy in preventing and treating BPD in preterm infants.
Biosynthetic response of cartilage explants to dynamic compression (1989)

The biosynthetic response of calf articular cartilage explants to dynamic compression was examined over a wide range of amplitudes, waveforms, and frequencies. Glycosaminoglycan synthesis was assessed by 35S-sulfate incorporation, and amino acid uptake and protein synthesis were assessed by 3H-proline incorporation. Two culture chambers were designed to allow uniaxial radially unconfined compression and mechanical testing of cartilage disks: one chamber was used inside a standard incubator; the other was used with a mechanical spectrometer and allowed load and displacement to be monitored during compression. Dynamic stiffness measurements of 3-mm diameter disks identified a characteristic frequency [0.001 Hz (cycles/sec)] that separated low- and high-frequency regimes in which different flow and deformation phenomena predominated; e.g., at 0.0001-0.0001 Hz, significant fluid was exuded from cartilage disks, whereas at 0.01-1 Hz, hydrostratic pressure increased within disks. At the higher frequencies, oscillatory strains of only approximately 1-5% stimulated 3H-proline and 35S-sulfate incorporation by approximately 20-40%. In contrast, at the lower frequencies (a) compressions of less than 5% had no effect, consistent with the dosimetry of biosynthetic inhibition by static compression (approximately 25% compression caused a approximately 20% inhibition of radiolabel incorporation), and (b) higher amplitudes (cycling between disk thicknesses of 1.25 and 0.88-1.00 mm) stimulated 3S-sulfate incorporation by approximately 20-40%, consistent with the kinetics of response to a single 2-h compression and release. None of the compression protocols was associated with detectable alterations in (e.g., compression-induced depletion of) total glycosaminoglycan content. This study provides a framework for identifying both the physical and biological mechanisms by which dynamic compression can modulate chondrocyte biosynthesis. In addition, the culture and compression methodology potentially allows in vitro evaluation of clinical strategies of continuous passive motion therapy to stimulate cartilage remodeling.
Hölder Eşitsizliğiyle Tabakalı Tesadüfi Örneklemede En Uygun Paylaştırma (2003)

Bilindigi gibi tabakali tesadufi orneklemede en uygun paylastirma yontemi uc farkli yaklasimla ele alinir. Bu yontemler Lagrange Carpanlar teknigi, dogrusal yada dogrusal-olmayan optimizasyon teknikleri ve esitsizlikler olarak bilinir. Bu calismamizda her zaman kullanilan toplam ornekleme maliyeti fonksiyonunu daha esnek bir fonksiyonla tanimlayarak ve Holder esitsizligi ile en uygun paylastirma icin ornek hacmini ve tabaka ornek hacimlerini belirleyen formulleri gosterdik. Goruldugu gibi bu formuller hesaplama kolayligi saglar.
Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human (2016)

The role of sphingosine 1-phosphate (S1P) in liver fibrosis or inflammation was not fully examined in human. Controversy exists which S1P receptors, S1P1 and S1P3 vs S1P2, would be importantly involved in its mechanism. To clarify these matters, 80 patients who received liver resection for hepatocellular carcinoma and 9 patients for metastatic liver tumor were enrolled. S1P metabolism was analyzed in background, non-tumorous liver tissue. mRNA levels of sphingosine kinase 1 (SK1) but not SK2 were increased in livers with fibrosis stages 3-4 compared to those with 0-2 and to normal liver. However, S1P was not increased in advanced fibrotic liver, where mRNA levels of S1P transporter spinster homolog 2 (SPNS2) but not S1P-degrading enzymes were enhanced. Furthermore, mRNA levels of S1P2 but not S1P1 or S1P3 were increased in advanced fibrotic liver. These increased mRNA levels of SK1, SPNS2 and S1P2 in fibrotic liver were correlated with α-smooth muscle actin mRNA levels in liver, and with serum ALT levels. In conclusion, S1P may be actively generated, transported to outside the cells, and bind to its specific receptor in human liver to play a role in fibrosis or inflammation. Altered S1P metabolism in fibrotic liver may be their therapeutic target.
Performance analysis of distributed search in open agent systems (2004)

In open multi-agent systems agents need resources provided by other agents but they are not aware of which agents provide the particular resources. Most solutions to this problem are based on a central directory that maintains a mapping between agents and resources. However, such solutions do not scale well since the central directory becomes a bottleneck in terms of both performance and reliability. In this paper, we introduce a different approach: each agent maintains a limited size local cache in which it keeps information about k different resources, that is, for each of k resources, it stores the contact information of one agent that provides it. This creates a directed network of caches. We address the following fundamental problem: how can an agent that needs a particular resource find an agent that provides it by navigating through this network of caches? We propose and analytically compare the performance of three different algorithms for this problem, flooding, teeming and random paths, in terms of three performance measures: the probability to locate the resource, the number of steps and the number of messages to do so. Our analysis is also applicable to distributed search in unstructured peer-to-peer networks.