gebhart/patrepeval huggingface dataset:
Effects of Protein and Gene Transfer of the Angiopoietin-1 Fibrinogen-like Receptor-binding Domain on Endothelial and Vessel Organization (2005)

The vessel-stabilizing effect of angiopoietin-1 (Ang1)/Tie2 receptor signaling is a potential target for pro-angiogenic therapies as well as anti-angiogenic inhibition of tumor growth. We explored the endothelial and vascular specific activities of the Ang1 monomer, i.e. dissociated from its state as an oligomer. A truncated monomeric Ang1 variant (i.e. DeltaAng1) containing the isolated fibrinogen-like receptor-binding domain of Ang1 was created and recombinantly produced in insect cells. DeltaAng1 ligated the Tie2 receptor without triggering its phosphorylation. Moreover, monomeric DeltaAng1 was observed to bind alpha(5)beta(1) integrin with similar affinity compared with Tie2. Unexpectedly, in vitro treatment of endothelial cells with DeltaAng1 showed some of the known effects of full-length Ang1, including inhibition of basal endothelial cell permeability and stimulation of cell adhesion as well as activation of MAPKs. Local treatment of the microvasculature of the developing chicken chorioallantoic membrane with the DeltaAng1 protein led to profound reduction of the mean vascular length density, thinning of vessels, and reduction of the number of vessel branching points. Similar effects were observed in side-by-side experiments with the recombinant full-length Ang1 protein. These effects of simplification of the vessel branching pattern were confirmed through local gene transfer with lentiviral particles encoding DeltaAng1 or full-length Ang1. Together, our findings suggest a potential use for exogenous Ang1 in reducing rather than increasing vascular density. Furthermore, we show that the isolated receptor-binding domain of Ang1 is capable of mediating some effects of full-length Ang1 independently of Tie2 phosphorylation, possibly through integrin ligation.
Segmentation of Low-Level Temporal Plume Patterns From IR Video (2019)

In this paper, a method to segment out gas or steam plumes in IR videos collected from fixed cameras is presented. We propose a spatio-temporal U-Net architecture that captures deforming blobs of gas/steam plumes that have a unique temporal signature. In this task, the blob shapes are not semantically meaningful and change from frame to frame with no consistency across different exemplar plumes; however, there is spatial and temporal continuity in the way blobs deform suggesting a need for a low-level spatio-temporal segmentation network. The proposed method is compared to an LSTM-based segmentation network on a challenging IR video dataset collected in a controlled environment. In the controlled dataset there is motion due to steam plumes with deforming blob patterns as well as due to walking people with more structured high-level patterns. The experiments show that plume patterns are successfully segmented out with no confusion to moving people and the proposed spatiotemporal U-Net outperforms LSTM-based network in terms of pixelwise accuracy of output masks.
Clinical Decisions In Glaucoma (1993)

This text provides a practical and expert problem-solving approach to the diagnosis and management of the glaucoma patient. The authors place emphasis on an approach to chronic, year-in, year-out care of the glaucoma patient - one of the most challenging management issues of the general ophthalmologists' practice. The first section of the book reviews the differential diagnosis of the patients who present with signs and symptoms suggestive of glaucoma, such as elevated pressure, abnormal optic nerve head, abnormal visual field and abnormal anterior chamber angle. The second section focuses on the chronic management of glaucoma. The authors describe the thought process/clinical decisions used to formulate and monitor treatment. In particular, they describe: how to determine the vigour with which to treat and monitor the individual patient; and how to determine if treatment is adequate and/or successful.
An Indoor Mobile Localization Strategy for Robot in NLOS Environment (2013)

This paper deals with the problem of localization of mobile robot in indoor environment with mixed line-of-sight/nonline-of-sight (LOS/NLOS) conditions. To reduce the NLOS errors, a prior knowledge-based correction strategy (PKCS) is proposed to locate the robot. This strategy consists of two steps: NLOS identification and mitigation. We propose an NLOS identification method by applying the statistical theory. Then we correct the NLOS errors by subtracting the expected NLOS errors. Finally, the residual weighting algorithm is employed to estimate the location of the robot. Simulation results show that the proposed strategy significantly improves the accuracy of localization in mixed LOS/NLOS indoor environment.
SLEEPNET: Automated Sleep Staging System via Deep Learning (2017)

Sleep disorders, such as sleep apnea, parasomnias, and hypersomnia, affect 50-70 million adults in the United States (Hillman et al., 2006). Overnight polysomnography (PSG), including brain monitoring using electroencephalography (EEG), is a central component of the diagnostic evaluation for sleep disorders. While PSG is conventionally performed by trained technologists, the recent rise of powerful neural network learning algorithms combined with large physiological datasets offers the possibility of automation, potentially making expert-level sleep analysis more widely available. We propose SLEEPNET (Sleep EEG neural network), a deployed annotation tool for sleep staging. SLEEPNET uses a deep recurrent neural network trained on the largest sleep physiology database assembled to date, consisting of PSGs from over 10,000 patients from the Massachusetts General Hospital (MGH) Sleep Laboratory. SLEEPNET achieves human-level annotation performance on an independent test set of 1,000 EEGs, with an average accuracy of 85.76% and algorithm-expert inter-rater agreement (IRA) of kappa = 79.46%, comparable to expert-expert IRA.
A PULSATILE BIOREACTOR FOR CONDITIONING TISSUE ENGINEERED HEART VALVES (2009)

Tissue engineered constructs with autologous adult stem cells capable of self-repair and growth are highly desired replacements for diseased heart valves. However, the current approaches have inadequate mechanical properties to withstand in vivo implantation. Therefore, our group hypothesized that an in vitro environment of physiological intra-cardiac pressures and flow will stimulate stem cells to differentiate and remodel valvular scaffold constructs before implantation. The group developed a pneumatic-driven conditioning system (Aim I) consisting of a three-chambered heart valve bioreactor, a pressurized compliance tank, a reservoir tank, one-way valves, pressure-retaining valves, and pressure transducers. The system can be sterilized using conventional autoclaving and ethylene oxide gas. The most novel feature is its ability to accommodate all clinically relevant sizes of stented or stentless biological, mechanical, or tissue engineered substitutes. A tissue derived heart valve substitute was used to test the bioreactor's functional capabilities (Aim II) at 60 beats per minute. The tests resulted in excellent opening and closing of the valve, pulsatile flows reaching 1400 mL per minute, and aortic pressures reaching 100 mmHg. The bioreactor then tested tissue engineered heart valves (Aim III) made from decellularized and lightly cross-linked tissues. Two stentless porcine aortic heart valves were conditioned in the bioreactor for 21 days. The first was seeded with adipose-derived stem cells (valve 1) and the second with aortic endothelial cells (valve 2). The third valve was made of valve-shaped fibrous sheets encasing a spongy collagen scaffold. It was seeded with human bone marrow-derived stem cells (valve 3) and conditioned in the bioreactor for 8 days. After progressive adaptation, valves were tested at 60 beats per minute and 10 mL per stroke. Each experiment also included a static control. The bioreactor created proper closing and opening of the heart valves and allowed for multiple mounting methods. Results indicated successful cell seeding and attachment in valves 1, 2, and 3; noticeable intercellular alignment in valves 2 and 3; and stem cell differentiation in valve 3. Overall, the conditioning system provides a dynamic three-dimensional cell culture setting designed to provide optimal physiological conditions for tissue engineered heart valve development over extended time periods. The group will continue to develop this approach to study multiple aspects of tissue engineered heart valve development and heart valve pathology.
Targeting Fibroblast Growth Factor Pathways in Prostate Cancer (2013)

Advanced prostate cancer carries a poor prognosis and novel therapies are needed. Research has focused on identifying mechanisms that promote angiogenesis and cellular proliferation during prostate cancer progression from the primary tumor to bone-the principal site of prostate cancer metastases. One candidate pathway is the fibroblast growth factor (FGF) axis. Aberrant expression of FGF ligands and FGF receptors leads to constitutive activation of multiple downstream pathways involved in prostate cancer progression including mitogen-activated protein kinase, phosphoinositide 3-kinase, and phospholipase Cγ. The involvement of FGF pathways in multiple mechanisms relevant to prostate tumorigenesis provides a rationale for the therapeutic blockade of this pathway, and two small-molecule tyrosine kinase inhibitors-dovitinib and nintedanib-are currently in phase II clinical development for advanced prostate cancer. Preliminary results from these trials suggest that FGF pathway inhibition represents a promising new strategy to treat castrate-resistant disease.
Oxidized lipids in the diet are a source of oxidized lipid in chylomicrons of human serum. (1994)

We examined whether oxidized lipids in the diet determine the levels of oxidized lipid in human postprandial serum chylomicrons. After we fed subjects control corn oil containing low quantities of oxidized lipid, the levels of conjugated dienes in the chylomicron fraction were low (9.67 +/- 0.92 nmol/mumol triglyceride), and no thiobarbituric acid-reactive substances (TBARS) could be detected. However, when subjects were fed a highly oxidized oil, the conjugated diene content in chylomicrons was increased 4.7-fold to 46 +/- 5.63 nmol/mumol triglyceride, with 0.140 +/- 0.03 nmol TBARS/mumol triglyceride. When subjects were fed medium-oxidized oil, the degree of oxidation of the chylomicron lipids was moderately increased (21.86 +/- 2.03 nmol conjugated dienes/mumol triglyceride). Additionally, we found that chylomicrons isolated after ingestion of oxidized oil were more susceptible to CuSO4 oxidation than chylomicrons isolated after ingestion of the control oil. The lag time for oxidation decreased from 4.30 +/- 0.40 to 3.24 +/- 0.51 hours (P < .05). These data demonstrate that in humans dietary oxidized lipids are absorbed by the small intestine, incorporated into chylomicrons, and appear in the bloodstream, where they contribute to the total body pool of oxidized lipid.
AUTOMATED SOFTWARE METRICS, REPOSITORY EVALUATION AND SOFTWARE ASSET MANAGEMENT: NEW TOOLS AND PERSPECTIVES FOR MANAGING INTEGRATED COMPUTER AIDED SOFTWARE ENGINEERING (I-CASE) (1991)

Automated collection of software metrics in computer aided software engineering (CASE) environments opens up new avenues for improving the management of software development operations, as well as shifting the focus of management's control efforts from "software projectâ to "software assets" stored in a centralized repository. Repository evaluation, a new direction for software metrics research in the 1990s, promises a fresh view of software development performance for a range of responsibility levels. We discuss the automation of function point and code reuse analysis in the context of an integrated CASE (I-CASE) environment deployed at a large investment bank in New York City. The development of an automated code reuse analysis tool prompted us to re-think how to measure and interpret code reuse in the I-CASE environment. The metrics we propose describe three dimensions of code reuse -- leverage, value and classification -- and we examine the value of applying them on a project and a repository-wide basis.
Measurements of Thermophysical Properties of Molten Materials from Oscillating and Rotating Drops (2000)

Certain physical properties of a molten drop, levitated, for example, in a high temperature eletrostatic levitator can be determined by inducing appropriate mechanical excitations on the drop.
Kinetics of volatile product evolution in coal pyrolysis: experiment and theory (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of volatile product evolution in coal pyrolysis: experiment and theoryMichael A. Serio, David G. Hamblen, James R. Markham, and Peter R. SolomonCite this: Energy Fuels 1987, 1, 2, 138–152Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://pubs.acs.org/doi/10.1021/ef00002a002https://doi.org/10.1021/ef00002a002research-articleACS PublicationsRequest reuse permissionsArticle Views3143Altmetric-Citations306LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The Extracellular Matrix Molecule Janusin Regulates Neuronal Morphology in a Substrate‐ and Culture Time‐dependent Manner (1994)

Janusin is an extracellular matrix glycoprotein with structural homology to tenascin. In search of extracellular matrix components which govern the differentiation of neurons in the central nervous system, we have investigated the influence of janusin on the differentiation of hippocampal neurons in vitro. Janusin coated onto nitrocellulose was a good substrate for attachment of cell bodies and neurite outgrowth after 21 h of culture. Most cells exhibited a polarized morphology with one long major neurite and one or two short minor neurites. When janusin was coated onto a polyornithine-conditioned plastic surface, it increased the polarity of neurons in that the length of major neurites was increased and the length and number of minor neurites were decreased when compared with the control polyornithine-conditioned plastic without janusin. As we have shown before for tenascin, laminin and fibronectin, polarization was preceded by an increase in the number and length of all neurites during the first hours after cell plating. This study therefore adds janusin to the increasing number of extracellular matrix glycoproteins which promote axonal but not dendritic growth.
Fluoranthene studies. III. A synthesis of 3-bromo-6-nitrofluorenone (1968)

A synthesis of 3-bromo-6-nitrofluorenone has been accomplished by the diazotization and Pschorr cyclization of 2-amino-4-bromo-4′-nitrobenzophenone, the synthesis of which is described. The identity of the above bromonitrofluorenone with the degradative oxidation product of 9-bromo-2-nitrofluoranthene establishes unequivocally the structure of the latter substance.
All-silicon carrier accumulation modulator based on a lateral metal-oxide-semiconductor capacitor (2018)

In silicon photonics, the carrier depletion scheme has been the most commonly used mechanism for demonstrating high speed electro-optic modulation. However, in terms of phase modulation efficiency, carrier accumulation based devices potentially offer almost an order of magnitude improvement over those based on carrier depletion. Previously reported accumulation modulator designs only considered vertical metal-oxide-semiconductor (MOS)-capacitors, which imposes serious restrictions on the design flexibility and integratability with other photonic components. In this work, for the first time we report experimental demonstration of an all-silicon accumulation phase modulator based on a lateral MOS-capacitor. Using a Mach-Zehnder interferometer (MZI) modulator with a 500-µm-long phase-shifter, we demonstrate high speed modulation up to 25 Gbit/s with a modulation efficiency (VπLπ) of 1.53 V-cm.
Synthetic peptides derived from E7 region of human papillomavirus type 16 used as antigens in ELISA (1990)

Nine overlapping peptides (20 amino acid) covering the entire sequence of early antigen E7 of human papillomavirus type 16 (HPV-16) were synthesized and tested as antigens with human sera in ELISA. Five of these peptides (no. 1 to 5 counting from the N terminus of the E7 protein) reacted with a pool of sera from HPV-16-infected individuals (as determined by molecular hybridization with their biopsy specimens); one (no. 5) was also reactive with pools of HPV-18- and HPV-6- or 11-infected individuals. Sera from 24 patients with cervical intraepithelial neoplasia (CIN) and from 29 invasive cervical carcinoma (INCA) patients were tested for the presence of antibodies reactive with peptides, no. 1 to 4 covering amino acids 1 to 50 and with peptide no. 5 covering amino acids 41 to 60. Only one of the sera from CIN patients was reactive with peptides no. 1 (amino acids 1 to 20) and no. 4 (amino acids 31 to 50). However, the majority of these sera reacted with peptide no. 5. The occurrence of this antibody was only slightly less frequent in sera from healthy subjects compared to CIN patients. On the other hand, sera from the INCA patients were reactive with the peptides no. 1 to 3 more frequently than the sera from matched control subjects. Positive reactions of sera from INCA patients were most frequently seen with no. 2; 24% of these sera but only 7% of the controls were reactive with no. 2 peptide. The present data suggest that no. 1 to 3 are HPV-16-specific, whereas no. 5 is broadly cross-reactive.
<title>Commercial machine vision system for traffic monitoring and control</title> (1992)

Traffic imaging covers a range of current and potential applications. These include traffic control and analysis, license plate finding, reading and storage, violation detection and archiving, vehicle sensors, and toll collection/enforcement. Experience from commercial installations and knowledge of the system requirements have been gained over the past 10 years. Recent improvements in system component cost and performance now allow products to be applied that provide cost effective solutions to the requirements for truly intelligent vehicle/highway systems (IVHS). The United States is a country that loves to drive. The infrastructure built in the 1950s and 1960s along with the low price of gasoline created an environment where the automobiles became an accessible and intricate part of American life. The United States has spent $DLR103 billion to build 40,000 highway miles since 1956, the start of the interstate program which is nearly complete. Unfortunately, a situation has arisen where the options for dramatically improving the ability of our roadways to absorb the increasing amount of traffic is limited. This is true in other countries as well as in the United States. The number of vehicles in the world increases by over 10,000,000 each year. In the United States there are about 180 million cars, trucks, and buses and this is estimated to double in the next 30 years. Urban development, and development in general, pushes from the edge of our roadways out. This leaves little room to increase the physical amount of roadway. Americans now spend more than 1.6 billion hours a year waiting in traffic jams. It is estimated that this congestion wasted 3 billion gallons of oil or 4% of the nation's annual gas consumption. The way out of the dilemma is to increase road use efficiency as well as improve mass transportation alternatives.
Inhibition of macrophage phagosome-lysosome fusion by Salmonella typhimurium (1991)

Salmonella typhimurium-infected macrophages were examined by electron microscopy to determine whether intracellular survival of S. typhimurium is associated with failure of bacteria containing phagosomes to fuse with secondary lysosomes. S. typhimurium 14028 actively inhibited phagosome-lysosome fusion and appeared to preferentially divide within unfused phagocytic vesicles. In comparison with Escherichia coli, S. typhimurium inhibited phagosome-lysosome fusion in peritoneal macrophages, J774 macrophages, and bone marrow-derived macrophages from both BALB/c (itys) and SWR/J (ityr) mice. The mechanism responsible for Salmonella inhibition of phagosome-lysosome fusion is unknown but requires viable salmonellae, is not blocked by opsonization with fresh normal mouse serum, and is not due to lipopolysaccharide. Inhibition of phagosome-lysosome fusion may play a critical role in survival of salmonellae within macrophages and in virulence.
Adaptive Modulation and Coding Based on Reinforcement Learning for 5G Networks (2019)

We design a self-exploratory reinforcement learning (RL) framework, based on the Q-learning algorithm, that enables the base station (BS) to choose a suitable modulation and coding scheme (MCS) that maximizes the spectral efficiency while maintaining a low block error rate (BLER). In this framework, the BS chooses the MCS based on the channel quality indicator (CQI) reported by the user equipment (UE). A transmission is made with the chosen MCS and the results of this transmission are converted by the BS into rewards that the BS uses to learn the suitable mapping from CQI to MCS. Comparing with a conventional fixed look-up table and the outer loop link adaptation, the proposed framework achieves superior performance in terms of spectral efficiency and BLER.
<title>Optoelectronic approach to optical parallel processing based on the photonic parallel memory</title> (1991)

A photonic parallel memory (PPM), an array of optoelectronic bistable switches, was proposed for application to optical parallel processing. Each of the switch consists of a heterojunction phototransistor (HPT) and a light-emitting diode (LED). In addition to the electrically erased PPM having only switches, an optically erasable PPM (OE-PPM) with functions of optical write-in, read-out and erasing was fabricated. The optical reset function was attained by an additional HPT connected to the switch electrically in parallel. The PPM can be used not only as a memory but as a logic gate. An optical parallel logic gate executing exclusive OR (EOR) was proposed as an application of the OE-PPM. The EOR operation with optical input and output was implemented.