gebhart/patrepeval huggingface dataset:
Effect of antiserum to human chorionic gonadotropin on growth and function of choriocarcinoma in vivo and in vitro. (1974)

The effects of antiserum to human chorionic gonadotropin (HCG) on growth and endocrine function of human choriocarcinoma serially transplanted in the cheek pouch of the hamster and maintained in tissue culture were examined. Anti-HCG serum given in amounts sufficient to neutralize the biological effect of the HCG secreted by the tumor significantly reduced tumor size. Since tumor growth was not enhanced by HCG administration or by ovariectomy, the antitumor effect could not be attributed to neutralization of the hormonal effects of the HCG. Anti-HCG serum had no effect on the growth of choriocarcinoma cells in vitro , suggesting that a host factor was required for the in vivo effect of the antiserum on tumor growth.
Silk Raising in Colonial Mexico. By Woodrow Borah. [Ibero-Americana: 20.] Berkeley and Los Angeles: University of California Press, 1943. Pp. vii, 169. Paper, $2.00. (1945)

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A novel nitrate ester reverses the cognitive impairment caused by scopolamine in the Morris water maze (2000)

The objective of this study was to test the hypothesis that activation of soluble guanylyl cyclase and increased cGMP formation in the brain would improve task acquisition in cognitively impaired animals. We evaluated the effects of a novel nitrate ester, GT 715 (2,3-dinitrooxy-(2,3-bis-nitrooxypropyldisulfanyl)-propane), in scopolamine-induced impairment of task acquisition in the Morris water maze. GT 715 improved task acquisition in scopolamine-pretreated animals in a time- and dose-dependent manner, whereas the prototypical nitrate ester, glyceryl trinitrate (GTN), was ineffective. GT 715 also was more effective and more potent than GTN for activation of hippocampal guanylyl cyclase. The results of this study therefore suggest that stimulation of cerebral soluble guanylyl cyclase activity may be an effective strategy to improve learning and memory performance in individuals in whom cognitive abilities are impaired by injury, disease, or ageing.
A PARALLELIZATION STRATEGY FOR THE DISCRETE TRANSFER RADIATION MODEL (1998)

Abstract An efficient strategy for the implementation of the discrete transfer radiation model on a parallel computer architecture is presented. The parallel version of the radiation model is evaluated by analyzing timing data for the computation of four test problems where the major parameters controlling numerical accuracy and computational cost are systematically varied. A semiempirical model for the parallel run time, calibrated using the timing data, is described. The model's range of application is restricted to the IBM SP2 computer architecture; however, it could be recalibrated for any parallel computer.
TIEMPO: an authoring and presentation system for interactive multimedia (1995)

The composition of interactive multimedia titles is a challenge for all advanced multimedia authoring tools. When non-interactive titles were specified by aligning the media items on a temporal axis such as time lines or tracks, now interactive multimedia titles require a non-linear temporal model. Thus, authoring becomes more complex, and the structure of a title is more difficult to visualize. TIEMPO addresses two areas: First, a temporal model satisfying the specification needs of interactive multimedia; Secondly, an interface for easy and rapid authoring of multimedia titles. This paper presents the architecture and design principles of the TIEMPO authoring and presentation environment.
Determination of carbohydrates in foods II.—Unavailable carbohydrates (1969)

Abstract A fractionation and analytical procedure is described for the measurement of the unavailable carbohydrates in foods. The scheme provides values for water‐soluble polysaccharides, hemicellulose, cellulose and lignin. Tests used to investigate the reliability of the methods are reported and the results obtained with a range of foodstuffs are presented. From the results obtained it is possible to derive values for the composition of the cell‐wall material of these foods. The results are in agreement with more detailed studies of the composition of the cell walls of plants.
Ueber die neuesten Fortschritte in der Lehre vom antiseptischen Wundverbande. Vortrag geh, am 14 (1884)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Exploring MicroRNA Biomarkers for Parkinson’s Disease from mRNA Expression Profiles (2018)

Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease characterized by both motor and nonmotor features. The diagnose of PD is based on a review of patients' signs and symptoms, and neurological and physical examinations. So far, no tests have been devised that can conclusively diagnose PD. In this study, we explore both microRNA and gene biomarkers for PD. Microarray gene expression profiles for PD patients and healthy control are analyzed using a principal component analysis (PCA)-based unsupervised feature extraction (FE). 244 genes are selected to be potential gene biomarkers for PD. In addition, we implement these genes into Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and find that the 15 microRNAs (miRNAs), hsa-miR-92a-3p, 16-5p, 615-3p, 877-3p, 100-5p, 320a, 877-5p, 23a-3p, 484, 23b-3p, 15a-5p, 324-3p, 19b-3p, 7b-5p and 505-3p, significantly target these 244 genes. These miRNAs are shown to be significantly related to PD. This reveals that both selected genes and miRNAs are potential biomarkers for PD.
Absence of oats toxicity in adult coeliac disease: Table 1 (1996)

Incidence of acute lymphoblastic leukaemia in young children increased with the "entropy" attributable to migration into their districts of resi- dence * Population mixing even at relatively low levels may be important in the aetiology of childhood leukaemia * The results provide further epidemiological evi- dence that childhood leukaemia might be a rare response to infection * Previous studies finding increased incidence in more affluent areas may have been indirectly observing a population mixing effect SOCIOECONOMIC STATUSWe are grateful to regional cancer registries, regional children's tumour registries, the UK Children's Cancer Study Group, the Clinical Trial Service Unit, and OPCS for providing notifications of cases of childhood leukaemia.We thank the many people who have worked on the National Registry of Childhood Tumours, particularly
Tryptophan fluorescence in hair-examination of contributing factors. (2011)

Various types of hair, including white (unpigmented), Piedmont (yellow-colored), blonde, brown, curly black of African origin, straight black of Chinese origin, and chemically processed (bleached) hair, were studied by using fluorescence spectroscopy. Fluorescence measurements were obtained by using a single- or double-grating fluorescence spectrophotometer and a bifurcated fiber optics accessory to measure the spectra directly from the surface of the hair. The results have shown that all types of hair share similar fluorescence characteristics, as recorded by excitation at 290 nm, 320 nm, 350 nm, and 380 nm, with emissions that could be ascribed to chromophores such as tryptophan (Trp), N-formylkynurenine, kynurenine, and 3-hydroxykynurenine. The relative intensities of fluorophore emissions were found to be dependent on factors such as melanin content and the history of UV light or thermal exposure. Trp fluorescence was also found to be dependent upon the state of the hair matrix. Softening of hair keratin by chemical reduction (breakage) of disulfide bonds or by hydration, leads to a 50%-100% increase in Trp emission intensity. Conversely, stiffening of the hair matrix by re-oxidation of reduced hair with hydrogen peroxide, or drying of wet hair, produces a decrease in fluorescence intensity. The results were interpreted by invoking the behavior of certain enzymes, which demonstrate Trp quenching by neighboring disulfide bonds or by hydrogen bonding with alanine residues, or with certain side-chain amino acids.
Evolution of the Functional Human β-Actin Gene and Its Multi-Pseudogene Family: Conservation of Noncoding Regions and Chromosomal Dispersion of Pseudogenes (1985)

We have assigned six members of the human beta-actin multigene family to specific human chromosomes. The functional gene, ACTB, is located on human chromosome 7, and the other assigned beta-actin-related sequences are dispersed over at least four different chromosomes including one locus assigned to the X chromosome. Using intervening sequence probes, we showed that the functional gene is single copy and that all of the other beta-actin related sequences are recently generated in evolution and are probably processed pseudogenes. The entire nucleotide sequence of the functional gene has been determined and is identical to cDNA clones in the coding and 5' untranslated regions. We have previously reported that the 3' untranslated region is well conserved between humans and rats (Ponte et al., Nucleic Acids Res. 12:1687-1696, 1984). Now we report that four additional noncoding regions are evolutionarily conserved, including segments of the 5' flanking region, 5' untranslated region, and, surprisingly, intervening sequences I and III. These conserved sequences, especially those found in the introns, suggest a role for internal sequences in the regulation of beta-actin gene expression.
Detection of New Antigenic Proteins in Japanese Cedar Pollen (2006)

In Japan, an increasing number of people suffer from pollenosis, a typical atopic disease. Japanese cedar (Cryptomeria japonica) pollen is the most common allergen that causes pollenosis. Although Cry j 1 and Cry j 2 are the common allergenic proteins contained in the pollen, there is a small population of patients who exhibit positive skin reactions to the pollen extract but are negative for both Cry j 1 and Cry j 2. This suggests that the pollen may contain other antigenic proteins besides these two molecules. In this study, we used sodium dodecyl sulfate-polyacrylamide gel electrophoresis to examine partially purified pollen extract (PPPE) and determine if there were other proteins that reacted to anti-PPPE sera collected from sensitized guinea pigs, mice and rabbits. Subsequently, we detected four bands of proteins with molecular weights around 7, 15, 20 and 31 kDa, which were different from those normally seen for Cry j 1 and Cry j 2. Among these, the 7, 15 and 20 kDa proteins could not be detected when anti-Cry j 1 monoclonal anti-body (mAb) and anti-Cry j 2 mAb were used as antibodies for Western blotting. Therefore, these three proteins may differ from Cry j 1 and Cry j 2 not only in molecular weight but also in antigenicity. In conclusion, three new antigenic proteins that are not identical to Cry j 1 and Cry j 2 have been shown to exist in Japanese cedar pollen. Structural analyses of these proteins may be useful in the development of new therapeutic methods, including specific immunotherapy for pollenosis.
A Tunable Polarization Beam Splitter Based on Magnetic Fluids-Filled Dual-Core Photonic Crystal Fiber (2017)

A tunable polarization beam splitter (PBS) is proposed based on a dual-core photonic crystal fiber (DCPCF). The DCPCF is filled with magnetic fluids in the air holes, whose refractive index varies with the magnetic field strength. The two polarized modes are separated into the two cores at the output ports in a magnetic-free condition. When magnetic field is applied, the output intensities of the two polarized modes would fluctuate. The polarized modes can be ported out with arbitrary proportion by adjusting the magnetic field intensity. Moreover, the polarized mode would be completely converted at some magnetic field strength. The properties of the DCPCF are investigated by the finite element method (FEM), including mode-conversion magnetic field strength, extinction ratio, fabrication tolerance of the PBS, and the performance of PBS at various temperatures. The numerical results show that at 1550-nm wavelength, the length of the tunable PBS is 8.13 mm. The polarized mode converts at a magnetic intensity of 25 mT with a high extinction ratio greater than -100 dB. In addition, the tunable PBS sustains a fabrication tolerance of at least 0.5% and works well at temperatures in the range of 0-55 °C by adjusting the magnetic field strength.
Expression profile of histone deacetylases 1, 2 and 3 in ovarian cancer tissues (2008)

HDACs1-3 are over expressed in ovarian cancer tissues and probably play a significant role in ovarian carcinogenesis.
Novel Scale Squeeze Technology and Treatment Designs for Improving Scale Inhibitor Retention and Treatment Lifetimes - Use of Ionic Polymers in the Overflush (2012)

Abstract A common method to prevent scale forming in oil production wells is to inject scale inhibitor into the formation in so called squeeze treatments. Conventional scale inhibitor treatments with a brine pre-flush, main scale inhibitor pill and brine over flush stages are often not considered to be economically efficient as a large proportion of the scale inhibitor introduced into the squeeze treatment is returned almost immediately and therefore does not serve to provide long term scale protection. Various techniques have been used successfully to increase the proportion of scale inhibitor retention in the well during squeeze treatments. For example, it has been reported previously in many papers where poly amino acids and poly quaternary amines have been injected into a well as part of the pre flush process and have significantly improved scale inhibitor retention and scale squeeze lifetimes. It has now been found that scale inhibitor treatment lifetimes can be improved by incorporating an ionic polymer such as a poly amino acid or poly quaternary amine in the over flush stage of the squeeze treatment. Indeed this method has been found to further extend the treatment lifetimes when combined with the same additives in the pre-flush stage of the scale squeeze treatment. The new scale squeeze design technology can be considered very flexible as it can be applied with most scale inhibitor chemistries including both phosphonates and polymers with minimal formation damage potential compared to most precipitation scale squeeze treatments. It should be applicable over a wide temperature range from 30°C to 200°C and, in addition, the treatment strategy also lends itself to both aqueous and non-aqueous deployment and hybrid treatments and could provide extra protection against fines production in water sensitive wells depending upon the ionic polymer deployed. Initial field treatments have demonstrated the potential to extend treatment lifetimes by retaining up to 20 to 50% more useful chemical in the treatment reservoir. This paper will highlight the proposed mechanisms of how the ionic polymer additives can improve squeeze treatment lifetimes as part of the over flush and will present field data for treatments on two wells in an HP/HT field at 165°C that demonstrated improved chemical retention and scale inhibitor returns compared to treatments without the ionic polymer additive in the over flush.
Perceptual multistability predicted by search model for Bayesian decisions (2008)

Perceptual multistability refers to the phenomenon of spontaneous perceptual switching between two or more likely interpretations of an image. Although frequently explained by processes of adaptation or hysteresis, we show that perceptual switching can arise as a natural byproduct of perceptual decision making based on probabilistic (Bayesian) inference, which interprets images by combining probabilistic models of image formation with knowledge of scene regularities. Empirically, we investigated the effect of introducing scene regularities on Necker cube bistability by flanking the Necker cube with fields of unambiguous cubes that are oriented to coincide with one of the Necker cube percepts. We show that background cubes increase the time spent in percepts most similar to the background. To characterize changes in the temporal dynamics of the perceptual alternations beyond percept durations, we introduce Markov Renewal Processes (MRPs). MRPs provide a general mathematical framework for describing probabilistic switching behavior in finite state processes. Additionally, we introduce a simple theoretical model consistent with Bayesian models of vision that involves searching for good interpretations of an image by sampling a posterior distribution coupled with a decay process that favors recent to old interpretations. The model has the same quantitative characteristics as our human data and variation in model parameters can capture between-subject variation. Because the model produces the same kind of stochastic process found in human perceptual behavior, we conclude that multistability may represent an unavoidable by-product of normal perceptual (Bayesian) decision making with ambiguous images.
Hughlings Jackson's rejection of the unconscious<sup>1</sup> (1993)

(1993). Hughlings Jackson's rejection of the unconscious. Journal of the History of the Neurosciences: Vol. 2, No. 1, pp. 65-78.
Localization of the alpha 1A-Adrenoceptor in the Human Prostate (1995)

To our knowledge, our study represents the first cellular localization of the alpha 1-adrenoceptor subtypes in the human prostate using highly selective alpha 1-adrenoceptor antagonists and is consistent with the physiological observation that the activity of prostatic smooth muscle is mediated by the alpha 1a-adrenoceptor.
BIENESTAR PSICOLOGICO Y ACTIVIDAD FÍSICA EN POBLACIONES CIEGAS Y CON DEFICIENCIAS VISUALES (1969)

Con el presente trabajose intenta detectar la percepción, que tienen las personas con deficiencia visual, de los beneficios producidospor la actividad física y/o el deporte. Estos beneficios percibidos por los sujetos han sido estudiados atendiendoa la edad, sexo, tipo de deficiencia y momento de aparición de la deficiencia en los mismos. El estudio decarácter eminentemente descriptivo se realizó con una muestra 130 sujetos ciegos y/o con deficiencia visual.Los resultados sugieren que los beneficios percibidos son valorados muy positivamente y representan unaamplia gama. Igualmente se aprecian ciertas diferencias atendiendo a la edad, sexo, tipo de deficiencia (total oparcial) y momento de aparición de la misma (desde el nacimiento o adquirida posteriormente). Como aspectosmás concretos destacan la capacidad física, sentirse bien consigo mismo, la diversión y la relajación que supone para los sujetos.
Ram-Based Neural Networks (1998)

From the Publisher:
RAM-based networks are a class of methods for building pattern recognition systems. Unlike other neural network methods, they learn very quickly and as a result are applicable to a wide variety of problems. This important book presents the latest work by the majority of researchers in the field of RAM-based networks.
Unified extensible firmware interface: An innovative approach to DRAM power control (2011)

As computing becomes more pervasive across an ever-increasing array of devices and as more complex solutions are integrated in silicon, the role of intelligent firmware is becoming ever more critical for enabling and unleashing advanced platform capabilities. Furthermore, since enterprise servers rarely operate at their peak capacity, efficient power capping is deemed as a critical component of modern enterprise computing environments. In this paper we present the role of platform firmware in DRAM power estimation, optimization and control. We develop firmware assisted smarts that optimizes the DRAM locality as well as enhances the accuracy of the DRAM power limiting (RAPL).
Fabrication and characterization of nanoresonating devices for mass detection (2000)

We report on a novel fabrication process and preliminary characterization of a nanomechanical resonating device, which is to be used for mass detection. The fabrication of the device is based on laser lithography on Al coated SiO2/p++Si/SiO2/Si structures, followed by dry and wet etching. We have fabricated highly doped polysilicon free-hanging cantilevers and anchored drivers for lateral cantilever vibration, where the motion of the cantilever is parallel to the substrate. The cantilevers are actuated electrically by applying an ac voltage between the cantilever and driver. The laterally vibrating cantilever structures are approximately 30–50 μm in length, 1.8 μm in height, and 500 nm in width. The characterization of the resonators was performed by direct observation of the cantilever through an optical microscope. An electrical measuring technique is also presented and discussed. Typical values of resonant frequency and quality factor, at 1 atm, are approximately 500 kHz and 50, respectively. Moreover, a dependence of the resonant frequency on the applied dc voltage between the cantilever and driver has been found.
Temporo-spatial analysis of cortical activation by phasic innocuous and noxious cold stimuli – a magnetoencephalographic study (2002)

Clinical findings and recent non-invasive functional imaging studies pinpoint the insular cortex as the crucial brain area involved in cold sensation. By contrast, the role of primary (SI) and secondary (SII) somatosensory cortices in central processing of cold is controversial. So far, temporal activation patterns of cortical areas involved in cold processing have not been examined. Using magnetoencephalography, we studied, in seven healthy subjects, the temporo-spatial dynamics of brain processes evoked by innocuous and noxious cold stimulation as compared to tactile stimuli. For this purpose, a newly designed and magnetically silent cold-stimulator was employed. In separate runs, cold and painful cold stimuli were delivered to the dorsum of the right hand. Tactile afferents were stimulated by pneumatic tactile stimulation.Following innocuous cold stimulation (DeltaT=5+/-0.3 degrees C in 50+/-2ms), magnetic source imaging revealed an exclusive activation of the contra- and ipsilateral posterior insular cortex. The mean peak latencies were 194.3+/-38.1 and 241.0+/-31.7ms for the response in the ipsi- and contralateral insular cortex, respectively. Based on the measurement of onset latencies, the estimated conduction velocity of peripheral nerve fibres mediating cold fell in the range of Adelta-fibres (7.4+/-0.8 m/s). Noxious cold stimulation (DeltaT=35+/-5 degrees C in 70+/-12ms) initially activated the contra- and ipsilateral insular cortices in the same latency ranges as innocuous cold stimuli. Additionally, we found an activation of the contra- and ipsilateral SII areas (peak latencies 304+/-22.7 and 310.1+/-19.4ms, respectively) and a variable activation of the cingulate cortex. Notably, neither cold- nor painful cold stimulation produced an activation of SI. By contrast, the evoked cortical responses following tactile stimulation could be located to the contralateral SI cortex and bilateral SII. In conclusion, this study strongly corroborates the posterior insular cortex as the primary somatosensory area for cortical processing of cold sensation. Furthermore, it supports the role of SII and the cingulate cortex in mediating freeze-pain. Therefore, these results suggest different processing of cold, freeze-pain and touch in the human brain.