gebhart/patrepeval huggingface dataset:
Vascular responses of the spleen to nerve stimulation during normal and reduced blood flow (1968)

1. The splenic artery flow, the splenic weight and the arterial blood pressure were recorded in cats anaesthetized with sodium pentobarbitone.2. Oscillations in splenic artery flow and splenic weight were observed. Following occlusion and release of the splenic artery, there was a brief increase in flow to above the pre-occlusion level and the oscillations in flow were greatly increased in amplitude. It is suggested that the brief increase is a consequence of the reduction of arterial pressure and that the oscillations are due to synchronization of rhythmic activity of smooth muscle within the spleen.3. Stimulation of the splenic nerves resulted in decreases in splenic artery flow and splenic weight. The size of the responses varied with the frequency of stimulation and maximum responses in both flow and weight were obtained at about 3 impulses/sec.4. After stimulation for 10 min, the splenic weight response was maintained while the flow response showed some recovery towards the control level.5. When the splenic artery flow was reduced to about half the control level for periods up to 2 hr, the flow and weight responses to stimulation of the splenic nerves remained unchanged; the significance of this after a haemorrhage is discussed.6. Intravenous administration of atropine or propranolol did not affect the responses to nerve stimulation. After phenoxybenzamine, nerve stimulation caused a smaller decrease in splenic weight, while the splenic artery flow increased to above the control level. This increase was unaffected by atropine but abolished by propranolol.
Chemical composition, antioxidant capacity, and mineral extractability of <scp>S</scp>udanese date palm (<i><scp>P</scp>hoenix dactylifera</i> L.) fruits (2014)

The aim of the present work was to investigate the chemical composition, mineral extractability, and antioxidant capacity of six date palm varieties grown in Sudan. The results showed that Sudanese date varieties contained significantly different (P < 0.05) amounts of moisture, ash, fiber, oil, and carbohydrates, but have almost similar amounts of protein. Moreover, results revealed that date varieties contained significantly varied (P < 0.05) amounts of total polyphenols and total flavonoids, which ranged between 35.82 and 99.34 mg gallic acid equivalent/100 g and 1.74-3.39 mg catechin equivalent/100 g, respectively. The antioxidant activities of the studied date varieties were as follows: ferric-reducing antioxidant power (FRAP) was within the range of 2.82-27.5 mmol/100 g, chelation of Fe(2+) ion ranged from 54.31% to 94.98%, and scavenging of H2O2 ranged from 38.48% to 49.13%. There were many correlations (positive, negative, and weak) between antioxidant and mineral extractability of Sudanese date fruits.
Data-Driven Methods for the Detection of Causal Structures in Process Technology (2014)

In modern industrial plants, process units are strongly cross-linked with eachother, and disturbances occurring in one unit potentially become plant-wide. This can leadto a flood of alarms at the supervisory control and data acquisition system, hiding the originalfault causing the disturbance. Hence, one major aim in fault diagnosis is to backtrackthe disturbance propagation path of the disturbance and to localize the root cause of thefault. Since detecting correlation in the data is not sufficient to describe the direction of thepropagation path, cause-effect dependencies among process variables need to be detected.Process variables that show a strong causal impact on other variables in the process comeinto consideration as being the root cause. In this paper, different data-driven methods areproposed, compared and combined that can detect causal relationships in data while solelyrelying on process data. The information of causal dependencies is used for localization ofthe root cause of a fault. All proposed methods consist of a statistical part, which determineswhether the disturbance traveling from one process variable to a second is significant, and aquantitative part, which calculates the causal information the first process variable has aboutthe second. The methods are tested on simulated data from a chemical stirred-tank reactorand on a laboratory plant.
Reconstruction of In-Cylinder Pressure in a Diesel Engine from Vibration Signal Using a RBF Neural Network Model (2011)

<div class="section abstract"><div class="htmlview paragraph">This study aims at building an efficient and robust radial basis function (RBF) artificial neural network (ANN), to reconstruct the in-cylinder pressure of a diesel engine starting from the signal of a low-cost accelerometer placed on the engine block. The accelerometer is a perfect non-intrusive replacement for expensive probes and is prospectively suitable for production vehicles. The RBF network is trained using measurements from different engine operating conditions. Training data are composed of time series from the accelerometer and corresponding measured in-cylinder pressure signals. The RBF network is then validated using data not included in training and the results show good correspondence between measured and reconstructed pressure signal. Various network parameters are used to optimize the network quality. The accuracy of the predicted pressure signals is analyzed in terms of mean square error and of a number of parameters, such as maximum pressure, peak location, and mass burned fraction (MBF). Robustness is sought with respect to changes in the engine parameters as well as with respect to changes in the nature of the fuel. The encouraging results indicate that the prediction model based on RBF neural network can be incorporated in the design of fuel-independent real-time control of diesel engines.</div></div>
Resource provisioning with budget constraints for adaptive applications in cloud environments (2010)

Utility computing was a vision stated more than 40 years ago. It refers to the idea that computing resources and services can be delivered, utilized, and paid for as utilities such as water or electricity. The recent emergence of cloud computing is making this vision realizable. Examples of efforts in this area include Infrastructure as a Service (IaaS) providers like Amazon EC2 and Software as a Service (SaaS) providers like Google AppEngine and Microsoft Azure. More recently, there is a growing interest in the use of cloud computing for scientific computing, as evidenced by a large-scale funded project like Magellan, and new workshops.
Synthesis of d- and 1-sirenin and their absolute configurations (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of d- and 1-sirenin and their absolute configurationsHenry Rapoport and Jacob J. PlattnerCite this: J. Am. Chem. Soc. 1971, 93, 7, 1758–1761Publication Date (Print):April 1, 1971Publication History Published online1 May 2002Published inissue 1 April 1971https://doi.org/10.1021/ja00736a030RIGHTS & PERMISSIONSArticle Views619Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (539 KB) Get e-Alerts Get e-Alerts
Test structures for characterising a damascene CMP interconnect process (2002)

This paper presents some test structures that can be used to help characterize interconnect fabricated using a CMP damascene process. Electrical measurements of the test structures are compared with those obtained using an AFM and surface profiling.
Some Effects of Fluid Jet Dynamics on Ink Jet Printing (1976)

Synchronous ink jet printing systems use a small fluid ink stream, as produced by a pressurized ink through a small orifice, to produce ink images on a recording surface. The initial stream breaks up into a uniform sequence of similar droplets as a result of velocity variations injected by the orifice assembly. As the droplets form, individual droplets receive charges by induction. The charges imparted to droplets determine their flight path through an orthogonal deflection field to the recording surface or, alternatively, to an ink dump. The mechanism of drop formation, drop charging, drop deflection, and aerodynamic interactions between drops, and how these influence an ink jet printer's performance, are discussed. In addition, since the fluid dynamics limit the range of applications for ink jet printing, some limiting factors are described.
Integrated Voltage Regulators with Thin-Film Magnetic Power Inductors (2013)

Integration of alternative materials and devices with CMOS will expand functionality and improve performance of established applications in the era of diminishing returns from Moore's Law scaling. In particular, integration of thin-film magnetic materials will enable improvements in energy efficiency of digital computing applications by enabling integrated power conversion and management with on-chip power inductors. Integrated voltage reg- ulators will also enable fine-grained power management, by providing dynamic scaling of the supply voltage in concert with the clock frequency of synchronous logic to throttle power consumption at periods of low computational demand. Implementation of integrated power conversion requires high capacity energy storage devices. This is best achieved with integration of thin-film magnetic materials for high quality on-chip power inductors. This thesis describes a body of work conducted to develop integrated switch-mode voltage regulators with thin-film magnetic power inductors. Soft-magnetic materials and inductor topologies are selected and optimized, with intent to maximize efficiency and current density of the integrated regulators. Custom integrated circuits are designed and fabricated in 45nm-SOI to provide the control system and power-train necessary to drive the power inductors. A silicon interposer is designed and fabricated in collaboration with IBM Research to integrate custom power inductors by 2.5D chip stacking, enabling power conversion with current density greater than 10A/mm2. The concepts and designs developed from this work will enable significant improvements in performance-per-watt of future microprocessors.
Extended scaled neural predictor for improved branch prediction (2013)

A perceptron-based scaled neural predictor (SNP) was implemented to emphasize the most recent branch histories via the following three approaches: (1) expanding the size of tables that correspond to recent branch histories, (2) scaling the branch histories to increase the weights for the most recent histories but decrease those for the old histories, and (3) expanding most recent branch histories to the whole history path. Furthermore, hash mechanisms, and saturating value for adjusting threshold were tuned to achieve the best prediction accuracy in each case. The resulting extended SNP was tested on well-known floating point and integer benchmarks. Using the SimpleScalar 3.0 simulator, while different features have different impact depending on whether the test is floating point or integer, overall such a well-tuned predictor achieves an improved prediction rate compared to prior approaches.
Association amongEPHB2, TrkA, andMYCN expression in low-stage neuroblastomas (2001)

This observation points to the possibility that MYCN expression might contribute to favorable outcome of low-stage NBs.
Capillary-Scale Frontal Affinity Chromatography/MALDI Tandem Mass Spectrometry Using Protein-Doped Monolithic Silica Columns (2005)

Frontal affinity chromatography (FAC) interfaced with electrospray mass spectrometry (ESI-MS) has been reported as a potential method for screening of compound mixtures against immobilized target proteins. However, the interfacing of bioaffinity columns to ESI-MS requires that the eluent that passes through the protein-loaded column have a relatively low ionic strength to produce a stable spray. Such low ionic strength solvents can cause serious problems with protein stability and may also affect binding constants and lead to high nonspecific binding to the column. Herein, we report on the interfacing of bioaffinity columns to matrix-assisted laser desorption/ionization (MALDI) MS/MS as a new platform for FAC/MS studies. Capillary columns containing a monolithic silica material with entrapped dihydrofolate reductase were used for frontal affinity chromatography of small-molecule mixtures. The output from the column was combined with a second stream containing alpha-cyano-hydoxycinnamic acid in methanol and was deposited using a nebulizer-assisted electrospray method onto a conventional MALDI plate that moved relative to the column via a computer-controlled x-y stage, creating a semipermanent record of the FAC run. The use of MALDI MS/MS allowed for buffers with significantly higher ionic strength to be used for FAC studies, which reduced nonspecific binding of ionic compounds and allowed for better retention of protein activity over multiple runs. Following deposition, MALDI analysis required only a fraction of the chromatographic run time, and the deposited track could be rerun multiple times to optimize ionization parameters and allow signal averaging to improve the signal-to-noise ratio. Furthermore, high levels of potential inhibitors could be detected via MALDI with limited ion suppression effects. Both MALDI- and ESI-based analysis showed similar retention of inhibitors present in compound mixtures when using identical ionic strength conditions. The results show that FAC/MALDI-MS should provide advantages over FAC/ESI-MS for high-throughput screening of compound mixtures.
Curling-PCM: Application-specific wear leveling for phase change memory based embedded systems (2013)

Phase change memory (PCM) has been used as NOR flash replacement in embedded systems with its attractive features. However, the endurance of PCM keeps drifting down and greatly limits its adoption in embedded systems. As most embedded systems are application-oriented, we can better utilize PCM by exploring application-specific features such as fixed access patterns and update frequencies to prolong the lifetime of PCM. In this paper, we propose an application-specific wear leveling technique, called Curling-PCM, to evenly distribute write activities across the PCM chip in order to improve the endurance of PCM. The basic idea is to exploit application-specific features in embedded systems and periodically move the hot region across the whole PCM chip. To further reduce the overhead of moving the hot region and improve the performance of PCM-based embedded systems, a fine-grained partial wear leveling policy is proposed in Curling-PCM, by which only part of the hot region is moved during each request handling period. The experimental results show that Curling-PCM can effectively evenly distribute write traffic in PCM chips compared with previous work. We expect this work can serve as a first step towards the full exploration of application-specific features in PCM-based embedded systems.
Design and Fabrication of Broad-Band EMC Filter for Power Line (2002)

제안된 EMC 필터는 높은 투자율의 페라이트 비드와 관통형 콘덴서로 구성하여 제작하였고, 10 MHz ~ 1.5 GHz에서 전원선에서 광대역 노이즈 신호에 대한 EMC 요구를 만족시킨다. 최적의 필터를 설계하기 위하여 페라이트 비드의 임피던스를 계산하여 찾았다. 그 결과, 광대역 EMC 필터는 차동모드 노이즈와 공통모드 노이즈에 대해 10 MHz ~ 1.5 GHz대역에서 30 dB 이상의 필터 특성을제안된 EMC 필터는 높은 투자율의 페라이트 비드와 관통형 콘덴서로 구성하여 제작하였고, 10 MHz ~ 1.5 GHz에서 전원선에서 광대역 노이즈 신호에 대한 EMC 요구를 만족시킨다. 최적의 필터를 설계하기 위하여 페라이트 비드의 임피던스를 계산하여 찾았다. 그 결과, 광대역 EMC 필터는 차동모드 노이즈와 공통모드 노이즈에 대해 10 MHz ~ 1.5 GHz대역에서 30 dB 이상의 필터 특성을 나타내었다. 그리고, DC ~ 1.8 GHz 주파수 대역에서 10 ~ 30 dB이상의 내성 특성을 향상시켰다. 나타내었다. 그리고, DC ~ 1.8 GHz 주파수 대역에서 10 ~ 30 dB이상의 내성 특성을 향상시켰다. The proposed EMC filter composed with feed-through capacitors and ferrite beads of high permeability was prepared which satisfy the EMC standard for a wide-band noise signal in the frequence of 10 MHz to 1.5 GHz in power supply line. The optimum structure of ferrite bead was found by calculating the load effect of ferrite beads. As a result, the filter showed excellent differential- and common-mode noises filtering characteristics above 30dB in the frequency band from 10 MHz to 1.5 GHz. The immunity characteristics are improved more than 10 to 30 dB over the frequency band from DC to 1.8GHz.
<title>A Flat Plate Multiple Pass Solar Collector Using Aqueous Optical Properties</title> (1978)

This paper describes a flat plate multiple pass solar collector which is believed to be new to the subject and gaps the need between concentrators (which typically are associated with high cost of manu-facture and vulnerability to the elements) and the conventional flat plate collectors (which typically reradiate as much energy as received on reaching a temperature level less than suitable for air conditioning. This new multiple pass flat plate collector performs optically by taking advantage of two fortuitous characteristics of plain water; one, high transparency in the visible spectrum, and two, near total opacity in the infrared. As solar energy heats the water, its potential radiative escape is via the infrared. A simple multiple pass system impacts the solar energy sequentially as it is blocked by opacity of the water in the earlier passages. The design is also such that it minimizes air convection losses by virtue of the layers of the multipass system. The function of the design has been confirmed by computer analysis. A model has been built and tests are in progress.
Hexafluoroisopropanol-Mediated Domino Reaction for the Synthesis of Thiazolo-androstenones: Potent Anticancer Agents (2018)

A cascade reaction of thioamides with 6β-bromoandrostenedione in hexafluoroisopropanol formed substituted thiazolo-androstenones. This is a simple and mild protocol to synthesize novel molecules by using readily available reagents and substrates. Feasibility of the reaction has been rationalized by density functional theory calculations. Moreover, these compounds are potent growth inhibitors of colon, central nervous system, melanoma, ovarian, and renal cancer cell lines with 50% growth inhibition values as low as 1.04 μM.
Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in<i>Escherichia coli</i> (2014)

Crystallography has advanced our understanding of G protein-coupled receptors, but low expression levels and instability in solution have limited structural insights to very few selected members of this large protein family. Using neurotensin receptor 1 (NTR1) as a proof of principle, we show that two directed evolution technologies that we recently developed have the potential to overcome these problems. We purified three neurotensin-bound NTR1 variants from Escherichia coli and determined their X-ray structures at up to 2.75 Å resolution using vapor diffusion crystallization experiments. A crystallized construct was pharmacologically characterized and exhibited ligand-dependent signaling, internalization, and wild-type-like agonist and antagonist affinities. Our structures are fully consistent with all biochemically defined ligand-contacting residues, and they represent an inactive NTR1 state at the cytosolic side. They exhibit significant differences to a previously determined NTR1 structure (Protein Data Bank ID code 4GRV) in the ligand-binding pocket and by the presence of the amphipathic helix 8. A comparison of helix 8 stability determinants between NTR1 and other crystallized G protein-coupled receptors suggests that the occupancy of the canonical position of the amphipathic helix is reduced to various extents in many receptors, and we have elucidated the sequence determinants for a stable helix 8. Our analysis also provides a structural rationale for the long-known effects of C-terminal palmitoylation reactions on G protein-coupled receptor signaling, receptor maturation, and desensitization.
Correction of spatial distortion in EPI due to inhomogeneous static magnetic fields using the reversed gradient method (2004)

The correction was improved by the application of a nonlinear interpolation scheme. The correction requires that two EP images be acquired at each slice position. This increases the acquisition time, but an improved signal-to-noise ratio (SNR) is seen in the corrected image. The local SNR gain decreases with increasing distortion. In many EPI acquisition schemes, multiple images are averaged at each slice position to increase the SNR; in such cases the reversed gradient correction method can be applied with no increase in acquisition duration.
Signaling Through Rho GTPase Pathway as Viable Drug Target (2009)

Signaling through the Rho family of small GTPases has been increasingly investigated for their involvement in a wide variety of diseases such as cardiovascular, pulmonary, and neurological disorders as well as cancer. Rho GTPases are a subfamily of the Ras superfamily proteins which play essential roles in a number of biological processes, especially in the regulation of cell shape change, cytokinesis, cell adhesion, and cell migration. Many of these processes demonstrate a common theme: the rapid and dynamic reorganization of actin cytoskeleton of which Rho signaling has now emerged as a major switch control. The involvement of dynamic changes of Rho GTPases in disease states underscores the need to produce effective inhibitors for their therapeutic applications. Fasudil and Y-27632, with many newer additions, are two classes of widely used chemical compounds that inhibit Rho kinase (ROCK), an important downstream effector of RhoA subfamily GTPases. These inhibitors have been successful in many preclinical studies, indicating the potential benefit of clinical Rho pathway inhibition. On the other hand, except for Rac1 inhibitor NSC23766, there are few effective inhibitors directly targeting Rho GTPases, likely due to the lack of optimal structural information on individual Rho-RhoGEF, Rho-RhoGAP, or Rho-RhoGDI interaction to achieve specificity. Recently, LM11A-31 and other derivatives of peptide mimetic ligands for p75 neurotrophin receptor (p75(NTR)) show promising effects upstream of Rho GTPase signaling in neuronal regeneration. CCG-1423, a chemical compound showing profiles of inhibiting downstream of RhoA, is a further attempt for the development of novel pharmacological tools to disrupt Rho signaling pathway in cancer. Because of a rapidly growing number of studies deciphering the role of the Rho proteins in many diseases, specific and potent pharmaceutical modulators of various steps of Rho GTPase signaling pathway are critically needed to target for therapeutic intervention in cardiovascular disease, neurological disorders, and cancer progression.