gebhart/patrepeval huggingface dataset:
Adrenocorticosteroid receptor blockade and excitotoxic challenge regulate adrenocorticosteroid receptor mRNA levels in hippocampus (2001)

The mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) are glucocorticoid-activated transcription factors essential for maintenance of cellular homeostasis. Differential activation of these adrenocorticosteroid receptors (ACR) is thought to influence neuronal viability, particularly under challenging cellular conditions. The present study is designed to determine the effects of receptor blockade and excitotoxic insult on MR and GR mRNA expression and neuronal viability in hippocampus. Male Sprague--Dawley rats were pretreated for 48 hr with vehicle, MR antagonist spironolactone (SPIRO) (50 mg/kg, twice daily, s.c.), or GR antagonist RU486 (25 mg/kg, twice daily, s.c.) and subsequently injected with saline or the glutamate analog kainic acid (KA) (12 mg/kg i.p.). Twenty-four hr post-insult, MR and GR mRNA levels were assessed by in situ hybridization analysis, and hippocampal neurons were counted to assess KA-induced cell loss. MR blockade with SPIRO increased basal MR mRNA levels in hippocampal subregions CA1, CA3, and dentate gyrus (DG) and increased basal GR mRNA levels in CA3. GR blockade with RU486 increased basal GR mRNA levels in CA3. The excitotoxin KA decreased MR mRNA levels in CA1 and CA3, decreased GR mRNA levels in DG, and negated all antagonist-induced increases of ACR mRNAs. Cell counts quantifying KA damage indicated increased CA3 vulnerability to KA insult after treatment with MR antagonist spironolactone but demonstrated no significant cell loss in any other group or region. These results demonstrate dynamic regulation of hippocampal MR and GR mRNAs after ACR antagonist treatment and kainate toxicity, underscoring the potential importance of MR and GR availability to neuronal viability after insult.
Dialytic ascitic ultrafiltration in refractory ascites. (1982)

Nine patients with hepatic cirrhosis and refractory ascites underwent dialytic ascitic ultrafiltration with intraperitoneal reinfusion of the concentrated ascites. Ascites was removed via a peritoneal catheter and ultrafiltered using a hemodialyzer. The concentrate was continuously returned to the peritoneal space. A mean of 4.8 l of protein-free ascitic ultrafiltrate was removed without adverse effects over the course of the 3- to 5-h procedure. Preliminary evidence indicates a potential role for dialytic ascitic ultrafiltration in the management of refractory ascites.
Broadband High Directivity Multibeam Emission Through Transformation Optics-Enabled Metamaterial Lenses (2012)

A new broadband two- and three-dimensional, polarization independent coordinate transformation is introduced that is capable of mapping the radiation from an embedded omnidirectional source into any desired number of highly directive beams pointed in arbitrary directions. This transformation requires anisotropic materials, yet is spatially invariant and thereby can be readily implemented by currently existing metamaterial technologies. Moreover, the performance of the transformation is not sensitive to small material parameter variations, thus enabling a broad operational bandwidth. To validate the concept, a broadband 3-D coordinate transformation metamaterial lens fed by a simple monopole antenna was designed, fabricated and characterized, achieving a quad-beam radiation pattern over a 1.26:1 bandwidth with approximately 6-dB realized gain improvement in the <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$H$</tex></formula> -plane. In addition, the near-field coupling between the monopole and the lens was carefully tuned to accomplish a remarkable 70% broadening of the impedance bandwidth compared to the monopole antenna operating alone. It is also shown from the field simulations that the realized metamaterial lens provides both near-field and far-field 3-D collimating effects.
Submerged liquid plasma – low energy synthesis of nitrogen-doped graphene for electrochemical applications (2014)

In this study, micro-plasma discharge is produced by applying a high electric potential between graphite and Pt electrodes in acetonitrile solvent.
A poly-algorithm for parallel dense matrix multiplication on two-dimensional process grid topologies (1997)

In this paper, we present several new and generalized parallel dense matrix multiplication algorithms of the form C = αAB + β C on two-dimensional process grid topologies. These algorithms can deal with rectangular matrices distributed on rectangular grids. We classify these algorithms coherently into three categories according to the communication primitives used and thus we offer a taxonomy for this family of related algorithms. All these algorithms are represented in the data distribution independent approach and thus do not require a specific data distribution for correctness. The algorithmic compatibility condition result shown here ensures the correctness of the matrix multiplication. We define and extend the data distribution functions and introduce permutation compatibility and algorithmic compatibility. We also discuss a permutation compatible data distribution (modified virtual 2D data distribution). We conclude that no single algorithm always achieves the best performance on different matrix and grid shapes. A practical approach to resolve this dilemma is to use poly-algorithms. We analyze the characteristics of each of these matrix multiplication algorithms and provide initial heuristics for using the poly-algorithm. All these matrix multiplication algorithms have been tested on the IBM SP2 system. The experimental results are presented in order to demonstrate their relative performance characteristics, motivating the combined value of the taxonomy and new algorithms introduced here. © 1997 by John Wiley & Sons, Ltd.
SBAR filter monolithically integrated with HBT amplifier (2002)

The authors describe the successful monolithic integration of bulk acoustic filters with gallium arsenide integrated circuits. Data are presented for a filter-amplifier chip with a center frequency of 1023 MHz, a 4 MHz bandwidth, and +14 dB gain. The size of the filter-amplifier chip is 1.6*3.2 mm. The monolithic filter is an SBAR (semiconductor bulk acoustic resonator) stacked crystal filter. The filter was fabricated with sputtered aluminum nitride piezoelectric films. The active circuit is a gallium arsenide HBT amplifier. The amplifier is a two-stage design and has biasing resistors and coupling capacitors on-chip. The integration process for the monolithic SBAR-HBT filter-amplifier is outlined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mitogen-activated protein kinase phosphatase-1 in rat arterial smooth muscle cell proliferation. (1996)

Smooth muscle cell proliferation and migration is important in arteriosclerosis. In this process, cytokines and growth factors are upregulated and bind to their respective receptors, which in turn stimulate mitogen-activated protein (MAP) kinases. MAP kinases then relay signals to the nucleus that activate quiescent smooth muscle cells. Phosphatases downregulate MAP kinases. We investigated the role of a dual-specificity tyrosine phosphatase, MAP kinase phosphatase-1 (MKP-1), in smooth muscle cell proliferation. MKP-1 expression was high in arterial tissue by Northern analysis, and MKP-1 message was detected mainly in the arterial smooth muscle layer by in situ hybridization. After balloon injury of the rat carotid artery, expression of MKP-1 decreased greatly, whereas that of MAP kinases, especially p44 MAP kinase, increased. The time course of the reduction in MKP-1 message correlated with increased tyrosine phosphorylation and elevated p44 MAP kinase enzymatic activity. In rat arterial smooth muscle cells overexpressing MKP-1, growth was arrested in the G1 phase and entry into the S phase was blocked. A reduction in MKP-1 expression may contribute in part to proliferation of smooth muscle cells after vascular injury, possibly through a decrease in dephosphorylation of p44 MAP kinase.
Induced translocation of glycosylphosphatidylinositol‐anchored proteins from lipid droplets to adiposomes in rat adipocytes (2009)

GPI proteins are translocated from DIGs to LD prior to their release into adiposomes, which is regulated by cholesterol, LD content and LD biogenesis. This detour may serve to transfer information about the LD content and to control lipolysis/esterification between large and small adipocytes via GPI protein-harbouring adiposomes.
Comparison of 4 and 6 French catheters for coronary angiography: real-world modeling. (2007)

Patients catheterized with 4F have fewer complications compared with 6F diagnostic catheters even when ambulated earlier. Although 4F had a reduced quality compared to 6F angiographies, they were evaluated as satisfactory or excellent in quality 85% of the time. 4F catheters have a potential for reduced hospitalization stay and are a good option for primary catheterization in patients not anticipated to undergo coronary intervention.
A Decade in the Life of EXO 2030+375: A Multiwavelength Study of an Accreting X‐Ray Pulsar (2002)

Using BATSE and RXTE observations from 1991 April to 2001 August, we have detected 71 outbursts from 82 periastron passages of EXO 2030+375, a 42 s transient X-ray pulsar with a Be star companion, including several outbursts from 1993 August to 1996 April, when the source was previously believed to be quiescent. Combining BATSE, RXTE, and EXOSAT data, we have derived an improved orbital solution. Applying this solution results in a smooth profile for the spin-up rate during the giant outburst and results in evidence for a correlation between the spin-up rate and observed flux in the brighter BATSE outbursts. Infrared and Hα measurements show a decline in the density of the circumstellar disk around the Be star. This decline is followed by a sudden drop in the X-ray flux and a turnover from a spin-up trend to spin-down in the frequency history. This is the first Be/X-ray binary that shows an extended interval, about 2.5 yr, in which the global trend is spin-down, but the outbursts continue. In 1995 the orbital phase of EXO 2030+375's outbursts shifted from peaking about 6 days after periastron to peaking before periastron. The outburst phase slowly recovered to peaking at about 2.5 days after periastron. We interpret this shift in orbital phase followed by a slow recovery as evidence of a global one-armed oscillation propagating in the Be disk. This is further supported by changes in the shape of the Hα profile, which are commonly believed to be produced by a reconfiguration of the Be disk. The truncated viscous decretion disk model provides an explanation for the long series of normal outbursts and the evidence of an accretion disk in the brighter normal outbursts. Long-term multiwavelength observations such as these clearly add considerably to our knowledge of Be/X-ray binaries and the relationship among optical, infrared, and X-ray observations.
Characterization of the genetic locus responsible for the production of ABP-118, a novel bacteriocin produced by the probiotic bacterium Lactobacillus salivarius subsp. salivarius UCC118 The GenBank accession number for the sequence reported in this paper is AF408405. (2002)

ABP-118, a small heat-stable bacteriocin produced by Lactobacillus salivarius subsp. salivarius UCC118, a strain isolated from the ileal-caecal region of the human gastrointestinal tract, was purified to homogeneity. Using reverse genetics, a DNA fragment specifying part of ABP-118 was identified on a 10769 bp chromosomal region. Analysis of this region revealed that ABP-118 was a Class IIb two-peptide bacteriocin composed of Abp118alpha, which exhibited the antimicrobial activity, and Abp118beta, which enhanced the antimicrobial activity. The gene conferring strain UCC118 immunity to the action of ABP-118, abpIM, was identified downstream of the abp118beta gene. Located further downstream of abp118beta, several ORFs were identified whose deduced proteins resembled those of proteins involved in bacteriocin regulation and secretion. Heterologous expression of ABP-118 was achieved in Lactobacillus plantarum, Lactococcus lactis and Bacillus cereus. In addition, the abp118 locus encoded an inducing peptide, AbpIP, which was shown to play a role in the regulation of ABP-118 production. This novel bacteriocin is, to the authors' knowledge, the first to be isolated from a known human probiotic bacterium and to be characterized at the genetic level.
High-Performance Polymers from Lignin Degradation Products (1989)

High-performance polymers having 4-hydroxyphenyl, guaiacyl and syringyl groups were synthesized from lignin degradation products. Physical properties of the polymers were investigated by differential scanning calorimetry (DSC), thermogravimetry (TG), gel permeation chromatography (GPC), viscosity measurement, etc. The relationship between the chemical structure and physical properties of polymers was analyzed from the viewpoint of molecular design. It was found that physical properties such as molecular weight, solubility for solvents, crystallinity, relaxation in glassy state, thermal decomposition temperature, etc., could be controlled by the appropriate arrangements of chemical bonds and functional groups such as phenylene group, methoxyl group, alkylene group, etc.
Cell Death Pathways in Acute Ischemia/Reperfusion Injury (2011)

The consequence of myocardial ischemia is energetic stress, while reperfusion is accompanied by abrupt ionic shifts and considerable oxidative stress. Cells die by apoptotic and necrotic pathways. After the acute injury, the healing myocardium is subject to biomechanical stress and inflammation, which can trigger a smaller but more sustained wave of cell death, as well as changes in the metabolic and functional characteristics of surviving cells. The goal of cardioprotection is to prevent cell death during the acute injury as well as to modulate the detrimental processes that ensue during remodeling. This review will focus on acute injury, and the central premise is that mitochondria are the key determinant of cardiomyocyte fate.
Surface Treatment of Ti6Al4V Parts Made By Powder Bed Fusion Additive Manufacturing Processes using Electropolishing (2014)

This paper investigated the use of electropolishing on the surface treatment of the Ti6Al4V parts made by the powder bed fusion processes including direct metal laser sintering (DMLS) and electron beam melting (EBM). A non‐aqueous alcohol based electrolyte was used, and the relationship between the process and surface roughness was evaluated. Based on the results, the feasibility of electropolishing as a potential alternative post‐surface treatment for additive manufactured metal parts was discussed.
Internal passivation for suppression of device instabilities induced by backend processes (1992)

The concept of internal passivation has been introduced as a means of suppressing device degradation due to backend processes. The proposed concept has been demonstrated by tailoring the composition of a PECVD (plasma-enhanced chemical vapor deposition) oxide film to achieve such an internal passivation, resulting in a process with built-in reliability. Specifically, field inversion and hot carrier degradation induced by backend processing have been suppressed. The results have been duplicated on two different commercially available PECVD systems, establishing that neither the problem nor the solution was related to a specific deposition system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modular cryogenic interconnects for multi-qubit devices (2014)

We have developed a modular interconnect platform for the control and readout of multiple solid-state qubits at cryogenic temperatures. The setup provides 74 filtered dc-bias connections, 32 control and readout connections with -3 dB frequency above 5 GHz, and 4 microwave feed lines that allow low loss (less than 3 dB) transmission 10 GHz. The incorporation of a radio-frequency interposer enables the platform to be separated into two printed circuit boards, decoupling the simple board that is bonded to the qubit chip from the multilayer board that incorporates expensive connectors and components. This modular approach lifts the burden of duplicating complex interconnect circuits for every prototype device. We report the performance of this platform at milli-Kelvin temperatures, including signal transmission and crosstalk measurements.
Mapping the Density of Scattering Centers Limiting the Electron Mean Free Path in Graphene (2011)

Recently, giant carrier mobility μ (>10(5) cm(2) V(-1) s(-1)) and micrometer electron mean free path (l) have been measured in suspended graphene or in graphene encapsulated between inert and ultraflat BN layers. Much lower μ values (10000-20000 cm(2) V(-1) s(-1)) are typically reported in graphene on common substrates (SiO(2), SiC) used for device fabrication. The debate on the factors limiting graphene electron mean free path is still open with charged impurities (CI) and resonant scatterers (RS) indicated as the most probable candidates. As a matter of fact, the inhomogeneous distribution of such scattering sources in graphene is responsible of nanoscale lateral inhomogeneities in the electronic properties, which could affect the behavior of graphene nanodevices. Hence, high resolution two-dimensional (2D) mapping of their density is very important. Here, we used scanning capacitance microscopy/spectroscopy to obtain 2D maps of l in graphene on substrates with different dielectric permittivities, that is, SiO(2) (κ(SiO2) = 3.9), 4H-SiC (0001) (κ(SiC) = 9.7) and the very-high-κ perovskite strontium titanate, SrTiO(3) (001), briefly STO (κ(STO) = 330). After measuring l versus the gate bias V(g) on an array of points on graphene, maps of the CI density (N(CI)) have been determined by the neutrality point shift from V(g) = 0 V in each curve, whereas maps of the RS density (N(RS)) have been extracted by fitting the dependence of l on the carrier density (n). Laterally inhomogeneous densities of CI and RS have been found. The RS distribution exhibits an average value ∼3 × 10(10) cm(-2) independently on the substrate. For the first time, a clear correlation between the minima in the l map and the maxima in the N(CI) map is obtained for graphene on SiO(2) and 4H-SiC, indicating that CI are the main source of the lateral inhomogeneity of l. On the contrary, the l and N(CI) maps are uncorrelated in graphene on STO, while a clear correlation is found between l and N(RS) maps. This demonstrates a very efficient dielectric screening of CI in graphene on STO and the role of RS as limiting factor for electron mean free path.
Auction-based effective bandwidth allocation mechanism (2003)

A bandwidth allocation system is proposed by using GVA (Generalized Vickrey Auction), which can be used for leasing lines, reselling lines, or allocating bandwidth to individual users. In the proposed system, network resources, which are composed of many links at various bandwidths, are regarded as multiple units. The application of GVA protocol to bandwidth allocation among multiple users is also described. Algorithmic and accounting issues are investigated inside multiple nodes in an end-to-end approach. Then, the performance of the proposed method is analyzed by using a computer simulation. In the simulation, the proposed method is compared with the other method in the conventional study of simple first come first served method. This analysis shows the effectiveness of the proposed system. By adopting the proposed system, the total utility of users can be maximized and the utilization rate of network resources can also be improved.
Synthesis of Prostaglandin-Fl Related Compounds (1972)

Synthesis of several prostaglandin-F1, related compounds utilizing bicyclo(2, 2, 1) heptene derivatives as key intermediates were investigated.
Communicative Competences and the Use of ICT for Foreign Language Learning within the European Student Exchange Programme ERASMUS (2011)

This article presents the results from a mainly statistical and comparative analysis regarding the communicative competences and the use of information and communication technologies (ICTs) of German exchange students. The data was extracted from two exhaustive, rigorous and methodical questionnaires related to communicative and ICT competences, which were completed by 20 exchange students from the Romanisches Seminar at the University of Bonn, Germany, their native language being German, whilst learning Spanish as a foreign language. Generally, the results confirm that a six-month stay in a foreign country increases the use of ICT and widely improves language skills, which can also be referred to as communicative competences in Spanish for native speakers of German.
Regulating Mammalian Target of Rapamycin To Tune Vaccination-Induced CD8+ T Cell Responses for Tumor Immunity (2012)

Vaccine strategies aimed at generating CD8(+) T cell memory responses are likely to show augmented efficacy against chronic challenges like tumor. The abundance in variety of memory CD8(+) T cells behooves development of vaccine strategies that generate distinct memory responses and evaluate them for tumor efficacy. In this study, we demonstrate the ability of a variety of rapamycin treatment regimens to regulate virus vaccination-induced CD8(+) T cell memory responses and tumor efficacy. Strikingly, a short course of high-dose, but not low-dose, rapamycin treatment transiently blocks viral vaccination-induced mammalian target of rapamycin activity in CD8(+) T cells favoring persistence and Ag-recall responses over type 1 effector maturation; however, prolonged high-dose rapamycin administration abrogated memory responses. Furthermore, a short course of high-dose rapamycin treatment generated CD8(+) T cell memory responses that were independent of IL-15 and IL-7 and were programmed early for sustenance and greater tumor efficacy. These results demonstrate the impact a regimen of rapamycin treatment has on vaccine-induced CD8(+) T cell responses and indicates that judicious application of rapamycin can augment vaccine efficacy for chronic challenges.
Bots Coordinating Work in Open Source Software Projects (2019)

Increasingly, bots are being used to coordinate work in open source software projects. As mechanisms that ensure the smooth functioning of open source software projects, bot activity influences how scholars and practitioners understand open source software development.
Data, Data Everywhere (2013)

As individuals living in a rich technology and communication ecosystem we capture, encode and publish more data than ever before. This trend toward greater amounts of data is set to increase as technology is woven ever more into the fabric of our everyday lives, says Ben Banks MBCS, European Information Security Manager, RR Donnelley.