gebhart/patrepeval huggingface dataset:
PN Ranging Based on Noncommensurate Sampling: Zero-Bias Mitigation Methods (2017)

This paper proposes two methods to mitigate the zero bias of noncommensurate sampling based code-tracking loops to significantly improve the pseudonoise ranging accuracy. For the compensation-based method, a set of algorithms is developed to directly calculate the zero bias which is then removed from the range measurement. For the compensation-free method, a special category of sampling ratios are selected such that the zero bias is self-cancelled. Simulations validate the effectiveness of the proposed methods.
The Occurrence of GM4 and GM2 in Erythrocytes from Inbred Strains of Mice1 (1982)

Glycolipids of erythrocytes from inbred mice, C3H/He and CDF1, were analyzed. Galactosylceramide, glucosylceramide, GM4 and GM2 were separated and their structures were established. Sialic acid of GM4 was exclusively N-acetylneuraminic acid, while GM2 contained only N-glycolylneuraminic acid. The fatty acid composition of GM4 was very similar to that of galactosylceramide, and a similarity was also found between that of GM2 and glucosylceramide. These results suggest that erythroid cells of mice have two separate biosynthetic pathways of gangliosides. One is the pathway to GM4 (NeuAc) from galactosylceramide, and the other is that for synthesizing GM2 (NeuGc) from glucosylceramide.
Signal transduction and gene regulation: the nuclear response to cAMP (1994)

Transcription factors are recognized to be important nuclear targets for intracellular signal transduction systems.An increase in the intracellular levels of cyclic 3',5'-adenosine monophosphate (CAMP) is generated by the activation of adenylyl cyclase.This membrane-associated enzyme is stimulated upon the binding of specific receptors to their ligands via coupling with GTP-binding proteins (1).CAMP, in turn, binds cooperatively to two sites on the regulatory subunit of protein kinase A (PKA),l releasing the active catalytic subunit (2).This is translocated from its cytoplasmic and Golgi complex anchoring sites (3, 4) and phosphorylates its substrate (the serine in the context X-Arg-Arg-X-Ser-X) present in a number of cytoplasmic and nuclear proteins.It is remarkable that the elevation of intracellular CAMP levels can result in either stimulation or repression of specific gene expression (1, 5, 6), suggesting that complex, cell-specific molecular mechanisms must operate in the nucleus.The purpose of this review is to summarize the molecular aspects of the nuclear response to CAMP by connecting the biochemical and structural features of the regulatory factors with their physiological function.Activated PKA appears to modulate the function of nuclear factors that bind to DNA sequences present in the promoter regions of CAMP-inducible genes.Most of these genes contain one or a few CAMP-responsive elements (CREs) (1, 5, 6).The consensus CRE is constituted by the palindromic sequence TGACGTCA, which is strikingly similar to the binding site of the transcription factor AP-1 (1).Variations from the consensus CRE are common (1).The first nuclear factor to be cloned that binds to a CRE was CRE-binding protein (CREB) (7).CREB has been followed by many other proteins, which can be classified into several groups.They all belong to the basic region/ leucine zipper (bZip) transcription factor class (Fig. 1).In these proteins the DNA-binding domain is composed of a conserved region of about 30 amino acids, rich in basic residues.Immediately C-terminal to this basic region lies a region with a heptad leucine repeat.This can form a n amphipathic a-helix with the leucine residues aligned along one ridge, two of these helices associating in a coiled-coil conformation (leucine zipwhich will be available in December, 1994.Work in our laboratory is
Effect of Detergent on “Promiscuous” Inhibitors (2003)

The term "promiscuous" inhibitors has been coined for compounds whose inhibition mechanism involves the interaction of aggregates of many compound molecules with the target protein, rather than the binding of individual molecules. This paper demonstrates that promiscuous inhibitors can be differentiated from classical 1:1 inhibitors by the judicious use of detergents, making it possible to configure assays that significantly reduce this undesirable mechanism of inhibition without compromising assay performance.
Effect of image interactivity technology on consumer responses toward the online retailer (2005)

The present study empirically examined whether image interactivity technology (IIT), which enables the creation and manipulation of product images on a retailer's Web site, affects experiential value and instrumental value.This study also examined whether IIT affects telepresence (i.e., simulated experience with the product in a store) and how IIT, telepresence, and value variables affect consumer responses toward an online retailer. A proposed model was supported using an experimental design with 206 subjects and Analysis of Moment Structures. Significant hypothesized paths were found between level of IIT, telepresence, and value variables. In addition, telepresence, experiential value, and instrumental value produced significant hypothesized paths with consumer response variables (attitude, willingness to purchase, and willingness to patronize). Implications for Web site development and marketing apparel online are provided.
Modification of the platelet binding domain of von Willebrand Factor (vWF) (1986)

Bovine vWF has been modified with /sup 125/I-Bolton Hunter reagent (I/sup */-BHR) with a concomittant loss of its platelet agglutinating activity and a reduction in its ability to bind to platelets. BHR labels free alpha and epsilon amino groups. The I/sup */-BHR-vWF migrated as a single band of M/sub r/ = 210kD on reduced SDS polyacrylamide gels. Its multimeric composition on SDS agarose gels was identical to unlabeled vWF. Incorporation of an average of 1.2 moles of I/sup */-BHR/subunit vWF at pH 8.5 caused a 50% loss of platelet agglutinating activity. This represents less than 2% of the 118 lysine residues in each subunit vWF. No I/sup */-BHR was released after treatment with 1M hydroxylamine which would cleave O-acylated tyrosines. Digestion of both unlabeled and I/sup */-BHR-vWF with Protease 1, a metalloprotease from the venom of western diamondback rattlesnake, produces two fragments which have an M/sub r/ of 250kD and 200kD. The 250kD fragment contains the platelet binding site and is composed of 3 peptide chains with M/sub r/ 125kD, 78kD and 45kD. Gels of the 250kD fragment from I/sup */-BHR-vWF revealed radioactivity predominantly in the 125kD fragment, suggesting that the platelet binding site resides on the 125kD fragment.
Human chorionic gonadotropin (hCG) inhibits cisplatin-induced apoptosis in ovarian cancer cells: Possible role of up-regulation of insulin-like growth factor-1 by hCG (1998)

Gonadotropins have been suggested to play a role in the development or progression of ovarian cancer, and we have previously reported the expression of luteinizing hormone/ human chorionic gonadotropin (LH/hCG) receptor in 40% of epithelial ovarian carcinomas. To examine the biological effect of LH/hCG on ovarian cancer cells, apoptosis induced by cisplatin with or without hCG treatment was investigated in 2 ovarian cancer cell lines, OVCAR-3 and SK-OV-3. Stimulation of cell proliferation by hCG was also studied. In addition, to analyze further the mechanism of hCG signaling involved in apoptosis-inhibition, we examined the expression of LH/hCG receptors and the regulation by hCG for apoptosis-inhibitory pathways, such as the bcl-2/bax system and the insulin-like growth factor-1 (IGF-1)/IGF-1 receptor (IGFR) system. hCG did not increase cell proliferation in either cell line. However, hCG treatment suppressed cisplatin-induced apoptosis by 58% in the OVCAR-3 cells, as shown by immunofluorescent staining and quantitation of DNA fragmentation. LH/hCG receptor mRNA was expressed only in OVCAR-3, and no apoptosis-inhibitory effect of hCG was observed in the SK-OV-3 cells that did not express the receptor. In the OVCAR-3 cells, hCG significantly increased mRNA expression of IGF-1, but did not change mRNA levels of bcl-2/bax. Our findings suggest that LH/hCG influences the chemosensitivity of ovarian cancer cells through an apoptosis-inhibitory signal possibly via up-regulation of IGF-1 expression.
<i>In vivo</i> Molecular Imaging of Cancer with a Quenching Near-Infrared Fluorescent Probe Using Conjugates of Monoclonal Antibodies and Indocyanine Green (2009)

Near-infrared (NIR) fluorophores have several advantages over visible fluorophores, including improved tissue penetration and lower autofluorescence; however, only indocyanine green (ICG) is clinically approved. Its use in molecular imaging probes is limited because it loses its fluorescence after protein binding. This property can be harnessed to create an activatable NIR probe. After cell binding and internalization, ICG dissociates from the targeting antibody, thus activating fluorescence. ICG was conjugated to the antibodies daclizumab (Dac), trastuzumab (Tra), or panitumumab (Pan). The conjugates had almost no fluorescence in PBS but became fluorescent after SDS and 2-mercaptoethanol, with a quenching capacity of 10-fold for 1:1 conjugates and 40- to 50-fold for 1:5 conjugates. In vitro microscopy showed activation within the endolysosomes in target cells. In vivo imaging in mice showed that CD25-expressing tumors were specifically visualized with Dac-ICG. Furthermore, tumors overexpressing HER1 and HER2 were successfully characterized in vivo by using Pan-ICG(1:5) and Tra-ICG(1:5), respectively. Thus, we have developed an activatable NIR optical probe that "switches on" only in target cells. Because both the antibody and the fluorophore are Food and Drug Administration approved, the likelihood of clinical translation is improved.
Design, synthesis and biological evaluation of CB1 cannabinoid receptor ligands derived from the 1,5-diarylpyrazole scaffold (2010)

The CB1 receptor belongs to the G-protein-coupled receptor superfamily. CB1 antagonism has been considered as a new therapeutic target for the treatment of obesity. In this study, we report the synthesis and in vitro binding affinity assay of some 1,5-diarylpyrazole scaffold compounds. The binding results showed that some of the target compounds had an excellent potency toward the CB1 receptor with IC₅₀ values lying at the nanomole level.
Two compounds in bed bug feces are sufficient to elicit off‐host aggregation by bed bugs, <i>Cimex lectularius</i> (2016)

Bed bug aggregation is mediated by semi-volatile compounds derived from fecal extracts, and two compounds are sufficient to elicit aggregation. The two compounds identified here could be used to enhance the effectiveness of insecticidal applications or improve monitoring techniques. © 2016 Society of Chemical Industry.
Lighting the fat furnace without SFRP5 (2012)

WNT signaling plays a central role in the regulation of cellular growth and differentiation. In this issue of the JCI, Mori et al. link WNT signaling to the oxidative capacity of adipocytes during obesity. They show that secreted frizzled-related protein 5 is an extracellular matrix-residing protein that is highly induced during obesity and inhibits oxidative phosphorylation in a tissue-autonomous manner, possibly by sequestering WNT3a. These results implicate local WNT signaling as an attractive target for combating obesity.
STABILIZATION OF THE ALCOHOLIC POTASSIUM HYDROXIDE IN COLORIMETRIC 17-KETOSTEROID DETERMINATIONS<sup>1</sup> (1947)

The 2.5 normal potassium hydroxide in absolute ethanol employed in the Callow modification of the Zimmermann reaction (Callow et ah, 1938), cannot be used for more than a few days after preparation. A marked increase in the color developed in reagent blank mixtures indicates deterioration even before the solution turns yellow. Various observations suggested that these changes are primarily oxidative. It therefore appeared probable that a suitable reducing agent would stabilize the solution. Experimental findings described below reveal that incorporation of ascorbic acid in the reagent, and maintenance of an atmosphere of nitrogen, yield preparations which remain stable for at least 3 months. Preparation of 2.5 N Alcoholic Potassium Hydroxide Protected with Ascorbic Acid and Nitrogen.—One hundred ml. of absolute alcohol are measured into a glass stoppered Pyrex bottle chilled in crushed ice. Two lots of 15 mg. each of ascorbic acid are weighed.
Factors Affecting Isolation and Propagation of Bovine Coronavirus in Human Rectal Tumor-18 Cell Line (1996)

Bovine coronavirus (BCV) is an important cause of calf enterocolitis and respiratory disease. It is the second major cause of viral diarrhea in calves, with rotavirus being the first. At the Wisconsin Animal Health Laboratory during 1993-1994, BCV was detected in 93 cases of calf scours out of 1,058 bovine fecal samples examined by direct electron microscopy. Electron microscopy is used commonly for the diagnosis of enteric viruses, including BCV. The advantages of electron microscopy are that diagnosis can be made rapidly and multiple pathogens, a common feature in enteritis, can be detected simultaneously. Using electron microscopy, more than a dozen novel enteric viruses have been described in the last 2 decades. However, electron microscopy has some limitations; approximately 1 million viral particles should be present to detect a virus by electron microscopy. Thus, it lacks sensitivity and can lead to false-negative results. In addition, some viruses, especially coronaviruses, can be confused morphologically with nonviral particles such as intestinal brush border epithelium and with other morphologically similar viruses, leading to false-positive results. Virus isolation is not commonly used for the diagnosis of BCV. However, 1 advantage is that the virus propagated in cell culture can be used for further antigenic and genomic characterization. To improve BCV isolation from clinical samples, factors affecting its isolation and propagation in human rectal tumor18 (HRT18) cell line were investigated. In a previous study, 10 HRT-18 was found to be a suitable cell line for BCV isolation. In this study, BCV propagated in vitro showed a change in hemagglutination pattern from that of the BCV from the original clinical samples. It is not known if this change correlates with changes in antigenicity and immunogenicity of the virus. HRT-18 and human colon tumor-8 (HCT-8) cells are derived from adenocarcinomas of human rectum and colon, respectively. 16 The 51 samples included in this study were provided by the Wisconsin Animal Health Laboratory (WAHL), Madison (n = 27), the California Veterinary Diagnostic Laboratory (CVDL), San Bernardino (n = 6), and another diagnostic laboratory (referred to as VDL for confidentiality) (n = 18). Samples were obtained as 20% fecal suspensions in phosphate-buffered saline (PBS) (pH 7.2), as
Liquid Ammonia Mediated Metathesis:  Synthesis of Binary Metal Chalcogenides and Pnictides (2001)

Addition of stoichiometric amounts of low valent metal halides to liquid ammonia solutions of disodium chalcogenide (Na(2)E; E = S, Se, Te) afforded a range of both crystalline (PbE (E = S, Se, Te), TlE (E = S, Se), Tl(5)Te(3), Ag(2)E (E = S, Se, Te)) and X-ray amorphous (MS (M = Ni, Cu, Zn, Cd, Hg), M(2)E(3) (M = Ga, In; E = S, Se, Te), HgE (E = Se, Te), CuE (E = S, Se, Te), Cu(2)S) metal chalcogenides in good yield (95%). Reactions between metal halides and sodium pnictides (Na(3)Pn; Pn = As, Sb) in liquid ammonia also afforded X-ray amorphous material (M(3)Pn(2), M = Zn, Cd; MPn, M = Fe, Co, Ni) in good yield (95%). Isolation of the metal chalcogenides and pnictides was achieved through washing with CS(2) and distilled water. All reactions were complete within 36 h. Products were characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDXA), electron probe analysis, FT-IR spectroscopy, Raman spectroscopy, microanalysis, and band gap measurements. Annealing amorphous material at 250-300 degrees C for 48 h induced sufficient crystallinity for analysis by X-ray powder diffraction.
Automatic keystone correction using a single camera (2015)

In this paper, we introduce an algorithm for removing keystone distortion, which frequently occurs when the projector is not precisely aligned to the screen, For this purpose, we generate a pre-warp image from the transformation between the projector and the screen using a single camera while automatically computing homography from the pattern and screen images and determining a scaled rigid body transform. Thus our method is useful for multi-projector-based applications.
Touch Your Heart: A Tone-aware Chatbot for Customer Care on Social Media (2018)

Chatbot has become an important solution to rapidly increasing customer care demands on social media in recent years. However, current work on chatbot for customer care ignores a key to impact user experience - tones. In this work, we create a novel tone-aware chatbot that generates toned responses to user requests on social media. We first conduct a formative research, in which the effects of tones are studied. Significant and various influences of different tones on user experience are uncovered in the study. With the knowledge of effects of tones, we design a deep learning based chatbot that takes tone information into account. We train our system on over 1.5 million real customer care conversations collected from Twitter. The evaluation reveals that our tone-aware chatbot generates as appropriate responses to user requests as human agents. More importantly, our chatbot is perceived to be even more empathetic than human agents.
Hepatitis B vaccines. On the threshold. (1978)

Experimental hepatitis B vaccines have recently been developed and are undergoing preliminary evaluation. These vaccines are unique in that they are prepared from viral antigen purified from the plasmas of human chronic carriers because hepatitis B virus has not been cultivated in vitro. They appear to be safe and antigenic, but care must be exercised in their evaluation because of the potential risks inherent in all vaccines.
A Meta-Analysis of the Effect of Glucagon-Like Peptide-1 (7–36) Amide on Ad Libitum Energy Intake in Humans (2001)

Seven studies have now been published pertaining to the acute effect of iv administration of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake. In four of these studies energy intake was significantly reduced following the glucagon-like peptide-1 infusion compared with saline. In the remaining studies, no significant effect of glucagon-like peptide-1 could be shown. Lack of statistical power or low glucagon-like peptide-1 infusion rate may explain these conflicting results. Our aim was to examine the effect of glucagon-like peptide-1 on subsequent energy intake using a data set composed of subject data from previous studies and from two as yet unpublished studies. Secondly, we investigated whether the effect on energy intake is dose dependent and differs between lean and overweight subjects. Raw subject data on body mass index and ad libitum energy intake were collected into a common data set (n = 115), together with study characteristics such as infusion rate, duration of infusion, etc. From four studies with comparable protocol the following subject data were included if available: plasma concentrations of glucagon-like peptide-1, subjective appetite measures, well-being, and gastric emptying rate of a meal served at the start of the glucagon-like peptide-1 infusion. Energy intake was reduced by 727 kJ (95% confidence interval, 548-908 kJ) or 11.7% during glucagon-like peptide-1 infusion. Although the absolute reduction in energy intake was higher in lean (863 kJ) (634-1091 kJ) compared with overweight subjects (487 kJ) (209-764 kJ) (P = 0.05), the relative reduction did not differ between the two groups (13.2% and 9.3%, respectively). Stepwise regression analysis showed that the glucagon-like peptide-1 infusion rate was the only independent predictor of the reduction in energy intake during glucagon-like peptide-1 (7-36) amide infusion (r = 0.4, P < 0.001). Differences in mean plasma glucagon-like peptide-1 concentration on the glucagon-like peptide-1 and placebo day (n = 43) were related to differences in feelings of prospective consumption (r = 0.40, P < 0.01), fullness (r = 0.38, P < 0.05), and hunger (r = 0.26, P = 0.09), but not to differences in ad libitum energy intake. Gastric emptying rate was significantly lower during glucagon-like peptide-1 infusion compared with saline. Finally, well-being was not influenced by the glucagon-like peptide-1 infusion. Glucagon-like peptide-1 infusion reduces energy intake dose dependently in both lean and overweight subjects. A reduced gastric emptying rate may contribute to the increased satiety induced by glucagon-like peptide-1.
Processing and interpretational aspects of spectral decomposition (1997)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1997Processing and interpretational aspects of spectral decompositionAuthors: James GridleyGreg PartykaJames GridleyAmoco Exploration and Production Technology Group and Greg PartykaAmoco Exploration and Production Technology Grouphttps://doi.org/10.1190/1.1885566 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1885566FiguresReferencesRelatedDetailsCited byAN OVERVIEW OF SEISMIC ATTRIBUTES1 July 2022References26 September 2016The Identification of the Strike-Slip Faults in Central Abdomen Junggar Basin and Its Petroleum Geological SignificancesAdvances in Geosciences, Vol. 04, No. 06The Wolf ramp: Reflection characteristics of a transition layerChristopher L. Liner and Bernhard G. Bodmann5 October 2010 | GEOPHYSICS, Vol. 75, No. 5Quantitative prediction of channel sand bodies based on seismic peak attributes in the frequency domain and its application10 June 2010 | Applied Geophysics, Vol. 7, No. 1Thin-bed thickness calculation formula and its approximation using peak frequency22 October 2009 | Applied Geophysics, Vol. 6, No. 3The Wolf Ramp: Early work on reflectivity dispersionChristopher L. Liner, Bernhard Bodman, and Gennady Goloshubin15 December 2008Spectral decomposition of 3‐D ground penetrating radar data from the Norman landfillIsabel C. Geerdes and Roger A. Young7 December 2005Thin‐bed AVO: Compensating for the effects of NMO on reflectivity sequencesAlessandro Castoro, Roy E. White, and Rhodri D. Thomas7 February 2012 | GEOPHYSICS, Vol. 66, No. 6Structural–formational interpretation tools for seismic stratigraphy4 January 2002 | Geophysical Prospecting, Vol. 48, No. 6 SEG Technical Program Expanded Abstracts 1997 ISSN (print):1052-3812 ISSN (online):1949-4645 Copyright: 1997 Pages: 2067 publication data© 1997 Copyright © 1997 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION James Gridley and Greg Partyka, (1997), "Processing and interpretational aspects of spectral decomposition," SEG Technical Program Expanded Abstracts : 1055-1058. https://doi.org/10.1190/1.1885566 Plain-Language Summary PDF DownloadLoading ...
FLOQUET MODAL ANALYSIS TO MODELIZE AND STUDY 2-D PLANAR ALMOST PERIODIC STRUCTURES IN FINITE AND INFINITE EXTENT WITH COUPLED MOTIFS (2015)

International audience
2,6-Diamino-3,5-Dinitropyridine-1-Oxide-A New Insensitive Explosive. (1995)

Abstract : A new insensitive explosive named 2,6,-diamino-3,5-dinitropyridine-1-oxide. modified abstract. jg