gebhart/patrepeval huggingface dataset:
Bone marrow transplantation using unrelated and family related donors: the impact of HLA-C disparity. (1996)

The clinical outcomes of unrelated and of family related allogeneic bone marrow transplantation (BMT) were correlated with HLA disparity in a study in which molecular phenotyping of HLA-C was performed for unrelated donor-recipient pairs. The study included 30 patients who underwent BMT from unrelated donors and 43 patients who underwent BMT from family related donors. The unrelated group included 14 full match pairs, 12 class-I-C (molecular HLA-C) mismatched pairs, and 4 haploidentical pairs. The family related group included 9 full match pairs, 19 class-I mismatched pairs, and 15 haploidentical pairs. In the unrelated BMT group, the transplant-related complications of mortality, graft-versus-host disease (GVHD), and graft rejection, were significantly higher in molecular HLA-C mismatched than matched patients (67% vs 14%, P < 0.02; 50% vs 7%, P < 0.02; 42% vs 0, P < 0.02). The actuarial survival and the disease free survival (DFS) at 18 months was better for molecular HLA-C matched than for HLA-C mismatched unrelated transplants: 33% vs 18% (P = 0.065, NS), and 29% vs 16%, respectively. For the family related BMT group, the actuarial survival at 18 months was significantly higher for patients who were fully matched compared to those who were class-I mismatched, or those who were haploidentical pairs: 67%, 37%, and 13% respectively (P < 0.02). The actuarial DFS at 18 months of patients who were fully matched and of those who were class-I mismatched was similar, and better than that of haploidentical patients 45%, 37% (NS) and 13% respectively (P < 0.045). A lower incidence of transplant-related mortality occurred in class-I mismatched, family related (37%) than in locus-C mismatched unrelated patients (67%), and no difference was observed in the fully matched family related and unrelated patients. We conclude that a mismatch in locus C may be detrimental to BMT outcome and should therefore be included as a risk factor in the routine pre-BMT HLA phenotyping.
La nueva regulación notarial de los títulos ejecutivos (2008)

En los ultimos anos, el notariado ha experimentado una profunda transformacion legislativa que ha trastocado la tecnica documental y, con ello, el sistema de algunos titulos ejecutivos previstos en el art. 517 de la LEC, tales como las escrituras publicas, las polizas mercantiles y el documento fehaciente de liquidacion, del art. 573 de la LEC . Toda esta nueva normativa notarial plantea ahora un grave problema de coordinacion con la legislacion procesal y convierte en una tarea compleja enjuiciar la regularidad formal del titulo ejecutivo, a los efectos de despachar ejecucion.
A Web Service Platform dedicated to building mixed reality solutions (2010)

While many attempts have been done towards creating mixed reality platforms for mobile client devices, there have not been any significant efforts at the server/infrastructure side. We demonstrate our Mixed Reality Web Service Platform (MRS-WS) dedicated to enabling rapid creation of mixed reality solutions, those being either desktop or mobile. Focusing on common interfaces and functions across user generated and commercial geo-content, we provide an appealing developer offering, which we are currently evaluating via a closed set of university partners. Our plan is to gradually expand the developer API access to more partners, before deciding if it is ready for fully public developer access.
Determination of the stoicheiometry of uranium dioxide by differential-pulse polarography (1984)

Uranium dioxide is widely used as a nuclear fuel and usually it exists as a non-stoicheiometric hyperstate UO2+x because of the oxygen interstitial arrangement. The proposed method for determining the oxygen to uranium ratio in uranium oxides is based on the dissolution of the nuclear fuel in concentrated phosphoric acid under an inert atmosphere, to preserve the uranium oxidation states. After complete dissolution, sulphuric acid is added in order to obtain a 1.47 M H3PO4–1.5 M H2SO4 supporting electrolyte. Differentialpulse polarographic determination of uranium(VI) directly follows at –0.09 V versus S.C.E. An aliquot of this solution is then oxidised with an almost equivalent amount of cerium(IV) sulphate solution, converting all uranium(IV) into uranium (VI); the total uranium content is then determined in the same way. The proposed method permits determinations of uranium(VI) levels as low as 0.2 µg ml–1 with a relative standard deviation of about 2%.The oxygen to uranium ratio is calculated by the equation O/U = 2.000 0 + U(VI)/total U and a result of 0.001 unit is obtainable with a coefficient of variation of about ±0.1%.
Growth abnormalities in Hfr Derivatives of Escherichia coli Strain c (1965)

SUMMARY From Escherichia coli strain c, made F+ by infection with the sex factor F normally carried by E. coli strain k-12, several Hfr (‘high frequency of recombination’) strains were derived. Among these, four were found which exhibited a defective growth pattern on minimal media at 37°. Reversion to the F+ state was accompanied by re-establishment of normal growth habit. In the case best studied (strain c-132) the Hfr bacteria form colonies smaller than normal, acquire a rough surface upon prolonged incubation, and are unable to grow at 42°. Growth is normal at room temperature and on rich media; it can be improved by the addition of methionine to minimal media. The rate of reversion from the Hfr to the F+ state (i.e. from defective to normal growth) is of the order of 1/20,000 per generation. Defective growth is not due to a genetic peculiarity of the F factor, nor is it dependent on the map location of the ‘ origin’ or leading end of the particular Hfr strain, or on its direction of chromosome transfer; possibly it results from the manner in which the F factor is integrated at any given chromosomal site.
Extraordinary Reinforcement Effect of Three-Dimensionally Nanoporous Cellulose Gels in Poly(ε-caprolactone) Bionanocomposites (2014)

Three-dimensionally nanoporous cellulose gels (NCG) were prepared by dissolution and coagulation of cellulose from aqueous alkali hydroxide-urea solution, and used to fabricate NCG/poly(ε-caprolactone) (PCL) nanocomposites by in situ ring-opening polymerization of ε-CL monomer in the NCG. The NCG content of the NCG/PCL nanocomposite could be controlled between 7 and 38% v/v by changing water content of starting hydrogel by compression dewatering. FT-IR and solid-state (13)C NMR showed that the grafting of PCL onto cellulose are most likely occurred at the C6-OH groups and the grafting percentage of PCL is 25 wt % for the nanocomposite with 7% v/v NCG. (1)H NMR, XRD, and DSC results indicate that the number-average molecular weight and crystal formation of PCL in the nanocomposites are remarkably restricted by the presence of NCG. AFM images confirm that the interconnected nanofibrillar cellulose network structure of NCG are finely distributed and preserved well in the PCL matrix after polymerization. DMA results show remarkable increase in tensile storage modulus of the nanocomposites above glass transition and melting temperatures of the PCL matrix. The percolation model was used to evaluate the mechanical properties of the nanocomposites, in which stress transfer among the interconnected nanofibrillar network is facilitated through strong intermolecular hydrogen bonding and entanglement of cellulose nanofibers.
Aggregation of steroidal lariat ethers: the first example of nonionic liposomes (niosomes) formed from neutral crown ether compounds (1988)

N-(3-Dihydrocholesteryloxycarbonylmethyl)-(1) and N-(3-cholesteryloxycarbonylmethyl)-1-aza-4,7,10,13-tetraoxa-cyclopentadecane (2) aggregate in water to from the first examples of niosomes based on amphiphiles having an uncomplexed crown ether residue as the head group.
Effects of an opiate on cold-induced pain and the CNS in healthy volunteers (1985)

The analgesic activity of an opiate was studied in 12 healthy volunteers using a cold-induced pain (CP) model. Effects on the central nervous system (CNS) were also measured. According to a double-blind, randomised, balanced, cross-over design with an interval of 7 days between occasions, subjects received single oral doses of 2, 4 and 8 mg dipipanone (D2, D4, D8) and a placebo. The CP test and a battery of measurements of CNS function were performed 3 times on each study day, once before and again 1.5 h and 3.0 h after treatment. Mean pain cores on a computerised visual analogue scale were significantly higher after placebo than those after 4 mg (P less than 0.05) and 8 mg (P less than 0.01) dipipanone and a dose-response relationship was evident. The opiate did not affect baseline blood pressure before the CP test but the hypertensive response to the painful cold stimulus was diminished 3 h after D8. Scores on scales for subjective assessment of alertness were significantly reduced 3 h after the 8 mg dose and pupil diameters were significantly smaller after all 3 doses of dipipanone. Body sway and visual near points were not significantly altered by the opiate. It is concluded that the CP test is a sensitive model for measurement of opiate-induced analgesia in healthy volunteers. Pupillometry and visual analogue scales are useful for the assessment of central effects of opiates.
Microsatellite Instability Associated with Primary Head and Neck Cancers and Secondary Esophageal Cancers (1998)

The results suggest that microsatellite instability may be implicated in the development of head and neck double cancers and that RER (+) phenotype may serve as a biomarker to predict the development of secondary esophageal cancer in patients with head and neck cancer.
Ballistic Phonon Thermal Transport in Multiwalled Carbon Nanotubes (2005)

We report electrical transport experiments, using the phenomenon of electrical breakdown to perform thermometry, that probe the thermal properties of individual multiwalled carbon nanotubes. Our results show that nanotubes can readily conduct heat by ballistic phonon propagation. We determine the thermal conductance quantum, the ultimate limit to thermal conductance for a single phonon channel, and find good agreement with theoretical calculations. Moreover, our results suggest a breakdown mechanism of thermally activated C-C bond breaking coupled with the electrical stress of carrying approximately 10(12) A/m2. We also demonstrate a current-driven self-heating technique to improve the conductance of nanotube devices dramatically.
Large magnetoelectric response in multiferroic polymer-based composites (2005)

A type of multiferroic polymer-based composite is presented which exhibits a giant magnetoelectric sensitivity. Such a multiferroic composite prepared via a simple low-temperature hot-molding technique for common polymer-based composites has a laminate structure with one lead-zirconate-titanate (PZT)/polyvinylidene-fluoride (PVDF) composite layer sandwiched between two $\mathrm{Tb}\mathrm{Dy}\mathrm{Fe}$ alloy (Terfenol-D)/PVDF composite layers. The PZT/PVDF layer in the middle dominates the dielectric and piezoelectric behavior of the polymer based composites. The coupling elastic interaction between two outer Terfenol-D/PVDF layers and the middle PZT/PVDF layer in such polymer-based composites produces the giant magnetoelectric response as demonstrated by the experimental results, especially at high frequency at which the electromechanical resonance appears. The maximum magnetoelectric sensitivity of the composites can reach up to as high as about $300\phantom{\rule{0.3em}{0ex}}\mathrm{mV}∕\mathrm{cm}\phantom{\rule{0.2em}{0ex}}\mathrm{Oe}$ at frequency below $50\phantom{\rule{0.3em}{0ex}}\mathrm{kHz}$ and about $6000\phantom{\rule{0.3em}{0ex}}\mathrm{mV}∕\mathrm{cm}\phantom{\rule{0.2em}{0ex}}\mathrm{Oe}$ at the resonance frequency of around $80\phantom{\rule{0.3em}{0ex}}\mathrm{kHz}$.
Robust adaptive nonlinear flight control applications using neural networks (1999)

Online neural networks are used to enhance feedback linearizing controllers of uncertain nonlinear systems. These systems may be non-affine with respect to the control. The controller architecture is based on inversion of a linearized plant model. A multi-layer perceptron neural network is added to compensate for the inversion error. Online weight update laws are derived from Lyapunov analysis, which guarantees boundedness of all signals. Robustness with respect to unmodeled input dynamics is provided by the addition of a nonlinear damper. The controller is demonstrated using the full, nonlinear models of the XV-15 tilt-rotor and the Caltech ducted fan. Numerical results demonstrate the effectiveness of the control in response to model inversion error, and degraded actuator performance.
VECTOR QUANTISATION BASED IMAGE ENHANCEMENT (2007)

Abstract: We present a new algorithm for rescaling images inspired by fractal coding. It uses a statistical model of the relationship between detail at different scales of the image to interpolate detail at one octave above the highest spatial frequency in the original image. We compare it with Bspline and bilinear interpolation techniques and show that it yields a sharper looking rescaled image. 1
Effects of implantation temperature on the properties of buried oxide layers in silicon formed by oxygen ion implantation (1984)

The effects of implantation temperature (Ti) on the chemical and physical structure of annealed high-dose oxygen ion implanted layers were investigated by Auger electron spectroscopy (AES) and transmission electron microscopy (TEM). At low Ti (∼400 °C) the buried oxide is bordered by layers of polycrystalline silicon (polysilicon) which, in the top silicon layer, is separated from damaged single crystal Si by a thin band of discontinuous oxide. These polysilicon layers are formed from amorphous regions during high-temperature anneals. At high Ti (∼500 °C) polysilicon was not observed.
Practical Issues in Bispectral Analysis of Electroencephalographic Signals (2001)

The aim of this report was to confirm the methodology of bispectral analysis of electroencephalogram. In developing a software for real-time bispectral analysis, we encountered several practical problems in bispectrum calculation. We settled those and concluded that 3 min of monitoring are required to obtain reliable and reproducible bicoherence values.
Cancellation of four-wave mixing in a single-mode fiber by midway optical phase conjugation (1994)

Cancellation of waves generated by four-wave mixing (FWM) in a single-mode fiber by use of midway optical phase conjugation is proposed and analyzed, and the possible power reduction is estimated. Effective cancellation of FWM is demonstrated with phase-conjugate waves generated by forward FWM in a zero-dispersion single-mode fiber, and a power reduction ratio of -13.9 dB is achieved in experimental three-channel transmission along a 40-km dispersion-shifted fiber.
Passive acoustic knock tracking for interactive windows (2002)

We describe a novel interface that locates and characterizes knocks and taps atop a large glass window. Our current setup uses four contact piezoelectric pickups located near the sheet's corners to record the acoustic wavefront coming from the knocks. A digital signal processor extracts relevent characteristics from these signals, such as amplitudes, frequency components and differential timings, which are used to estimate the location of the hit and provide other parameters, including the rough accuracy of this estimate, the nature of each hit (e.g., knuckle knock, metal tap, or fist bang), and the strike intensity. This system requires only simple hardware, needs no special adaptation of the glass pane, and allows all transducers to be mounted on the inner surface, hence it is quite easy to deploy as a retrofit to existing windows. This opens many applications, such as an interactive storefront, with projected content controlled by knocks on the display window.
Immune Tolerance Negatively Regulates B Cells in Knock-In Mice Expressing Broadly Neutralizing HIV Antibody 4E10 (2013)

A major goal of HIV research is to develop vaccines reproducibly eliciting broadly neutralizing Abs (bNAbs); however, this has proved to be challenging. One suggested explanation for this difficulty is that epitopes seen by bNAbs mimic self, leading to immune tolerance. We generated knock-in mice expressing bNAb 4E10, which recognizes the membrane proximal external region of gp41. Unlike b12 knock-in mice, described in the companion article (Ota et al. 2013. J. Immunol. 191: 3179-3185), 4E10HL mice were found to undergo profound negative selection of B cells, indicating that 4E10 is, to a physiologically significant extent, autoreactive. Negative selection occurred by various mechanisms, including receptor editing, clonal deletion, and receptor downregulation. Despite significant deletion, small amounts of IgM and IgG anti-gp41 were found in the sera of 4E10HL mice. On a Rag1⁻/⁻ background, 4E10HL mice had virtually no serum Ig of any kind. These results are consistent with a model in which B cells with 4E10 specificity are counterselected, raising the question of how 4E10 was generated in the patient from whom it was isolated. This represents the second example of a membrane proximal external region-directed bNAb that is apparently autoreactive in a physiological setting. The relative conservation in HIV of the 4E10 epitope might reflect the fact that it is under less intense immunological selection as a result of B cell self-tolerance. The safety and desirability of targeting this epitope by a vaccine is discussed in light of the newly described bNAb 10E8.
The Effects of Somatostatin Receptor Subtype Specific Agonists on Human Hepatocellular Carcinoma Cell (2011)

Objective To investigate the effect of somatostatin receptor subtype specific agonists on human hepatocellular carcinoma HepG2 cell line.Methods Effects of SSTR agonists on proliferation、apoptosis and migration of HepG2 were assessed by MTS、the TdT-mediated dUTP nick end labelin assay(TUNEL) and transwell,respectively.Results Compared with the controls,none of four SSTR agonists influenced proliferation or apoptosis of HepG2 in experimental group.However,SSTR5 agonist(L-817,818) showed an obvious inhibitory effect on migration when dosage was 1μg/ml and there was a statistical significance when the dosage reached at 5μg/ml(P0.05).Conclusion SSTR agonists have no significant effects on proliferation and apoptosis of HepG2.SSTR5 agonist(L-817,818) shows an obvious inhibitory effect on migration when the dosage is increasing.
Studies on comprehensive utilization technique of spirulina (2002)

Natural edible phycocyanin and palatable plant protein are available by isolating and treating released substances from the broken cell walls of spirulina processed with ultralow temperature and supersonic vibration. The technique also helps to obtain other healthy ingredients from spirulina. The paper discusses how to further process spirulina so as to get high value-added food.
Novel diagnostic features of dysferlinopathies (2010)

Reports of dysferlinopathy have suggested a clinically heterogeneous group of patients. We identified specific novel molecular and phenotypic features that help distinguish dysferlinopathies from other forms of limb-girdle muscular dystrophy (LGMD). A detailed history, physical exam, and protein and mutation analysis of genomic DNA was done for all subjects. Five of 21 confirmed DYSF gene mutations were not previously reported. A distinct "bulge" of the deltoid muscle in combination with other findings was a striking feature in all patients. Six subjects had atypical calf enlargement, and 3 of these exhibited a paradoxical pattern of dysferlin expression: severely reduced by direct immunofluorescence with overexpression on Western blots. Six patients showed amyloid deposits in muscle that extended these findings to new domains of the dysferlin gene, including the C2G domain. Correlative studies showed colocalization of amyloid with deposition of dysferlin. The present data further serve to guide clinicians facing the expensive task of molecular characterization of patients with an LGMD phenotype.
<i>Generalized Hypergeometric Functions</i> (1967)

1. The Gauss Function 2. The Generalized Gauss Function 3. Basic Hypergeometric Functions 4. Hypergeometric Integrals 5. Basic Hypergeometric Integrals 6. Bilateral Series 7. Basic Bilateral Series 8. Appell Series 9. Basic Appell Series.
Stress stimuli increase calcium-induced arachidonic acid release through phosphorylation of cytosolic phospholipase A2 (1999)

Stress stimuli such as free radicals, high osmolarity or arsenite activate stress-activated protein kinases (SAPKs) in a wide variety of cells. In the present study, we have investigated the ability of several stress stimuli to activate SAPKs in platelets and to induce phosphorylation of their substrates. Treatment of human platelets with H(2)O(2) stimulated SAPK2a and its downstream target mitogen-activated protein kinase-activated protein kinase-2 (MAPKAP-K2). Kinase activity reached a maximum after 2-5 min and declined towards basal levels after 15 min. Arsenite caused a steady increase of MAPKAP-K2 activity up to 15 min. The level of maximal kinase activation by H(2)O(2) and arsenite was comparable with the effect caused by the physiological platelet stimulus thrombin. A high osmolarity solution of sorbitol induced comparatively small activation of SAPK2a and MAPKAP-K2. The 42-kDa extracellular signal-regulated kinase (ERK) 2 was not activated by H(2)O(2), sorbitol or arsenite. None of these stimuli triggered significant arachidonic acid release on their own. However, H(2)O(2) and sorbitol enhanced the release of arachidonic acid induced by the calcium ionophore A23187. This effect was reversed by the inhibitor of SAPK2a, 4-(4-fluorophenyl)-2-(4-methylsulphinylphenyl)-5-(4-pyridyl) imidazole (SB 203580), but not by the inhibitor of the ERK2-activating pathway, 2-(2-amino-3-methoxyphenyl)-oxanaphthalen-4-one (PD 98059). Both H(2)O(2) and sorbitol increased phosphorylation of cytosolic phospholipase A(2) (cPLA(2)) and its intrinsic activity; both responses were blocked by SB 203580. Phosphorylation of cPLA(2) by H(2)O(2) occurred on Ser-505, a reaction that is known to increase the intrinsic lipase activity of the enzyme. Our results demonstrate that activation of SAPKs by stress stimuli primes cPLA(2) activation through phosphorylation. In vivo, this mechanism would lead to the sensitization of platelet activation and may be an important risk factor in thrombotic disease.
Energy Provision and Storage for Pervasive Computing (2016)

Soon, pervasive computers will enormously outnumber humans. Devices requiring sufficient energy to operate maintenance-free for periods of years and beyond render today's technologies insufficient. With the gap between energy requirements of embedded systems and achievable levels of harvested power reducing, viable hybrid energy and power management subsystems have emerged that combine harvesting with finite, rechargeable energy buffers. Coupled with advances in wireless power transfer and energy storage, the authors suggest that an energy design space is emerging. There are, as yet, no tools or systematic methods for design space exploration or engineering in this context. It's important to develop such a methodology, and critical to link it with methodologies for system design and verification. The authors discuss key factors such an energy design methodology should incorporate, including size, weight, energy and power densities; mobility; efficiencies of harvesters and buffers; time between charges, (dis)charge speeds, and charge cycles; and availability and predictability of harvestable energy. This article is part of a special issue on energy harvesting.
Organic–inorganic double shell composite microcapsules (2010)

Here we present novel double shell composite microcapsules (melamine formaldehyde (MF) polymer inner shell and ripened CaCO(3) nanoparticle outer shell) prepared using a method based on in situ polymerisation to form a MF polymer shell inside the ripened CaCO(3) nanoparticulate microcapsules wall.