gebhart/patrepeval huggingface dataset:
A Workstation-Based Mixed Mode Circuit Simulator (1986)

A new mixed mode simulator is described, which combines a behavioral timing simulator, a switch level simulator, and a new circuit-level simulator based upon the ADEPT timing simulation algorithm. These simulation algorithms are combined into a single, consistent, interactive MOS simulator. In addition, STAFAN fault simulation is provided at the transistor level to grade vectors to be used in the testing phase of design. In this paper, each algorithm is described as well as the interfacing required between each of the simulation methods. Several examples are presented to demonstrate the utility of the L-Simulator. Circuit simulation is performed on a wide range of CMOS counter sizes, from 2 to 32 bits, showing tremendous reductions in CPU time as compared to SPICE, without loss in accuracy. A novel multi-mode simulation facility is also introduced, further decreasing the CPU time requirements for simulation. A second example shows how the performance and area of a CMOS latch is optimized using circuit modification techniques during simulation. Finally, a 73,200 transistor design of an 8051-like CPU is simulated in behavioral, switch level, and finally in circuit/mixed modes.
Special Edition Using Microsoft Word 2002 (2001)

From the Publisher:

Special Edition Using Microsoft Word 2002 is the most detailed business-focused guide to Microsoft Word 2002 in the marketplace. More than any competitive book, it focuses on maximizing user productivity with real-world documents in real-world environments.
Topics covered include:
Using Word as an Email Editor
Using Word 10's Speech Command, Control and Dictation
Creating Organization Charts
Word Document Privacy and Security Options
Managing Document-Collaboration and Revisions
Creating a Real-World Solution with VBA and Word
Political Boundaries and Political Structure: The Limits of the Teuchitlan Tradition (1996)

Abstract Many social scientists have proposed a relationship between the structure of a boundary and that of the system it delimits. Substantial anthropological and historical research has found the same tendency in analyses of traditional political structure. A model based on these findings was applied to the Teuchitlan tradition of Classic-period West Mexico, a region where the degree of political complexity and unification has been a subject of debate. A focused study of the eastern boundary of the Teuchitlan Valley was undertaken to examine the nature of its political structure. Fieldwork located a number of defensive features forming a well-structured boundary system in the La Venta corridor that connects the Teuchitlan and Atemajac Valleys. Other fortifications ringing the Teuchitlan Valley strongly suggest that a defensive network had been established to monitor access into the core of the Teuchitlan area. A unitary, territorial form of administration (following the work of Southall and Luttwak) is proposed as a model for political dynamics in the core region, but a review of the evidence for the more-distant Teuchitlan architecture suggests that, at most, only a hegemonic form of control more akin to that of the segmentary state was exercised outside of the core valley. A connection with long-distance resource acquisition is possible, but highly speculative at present.
Renal Parenchymal Malakoplakia: Ultrastructural Findings in Different Stages of Morphogenesis (1994)

Light microscopic and ultrastructural findings in five cases of renal parenchymal malakoplakia detected in renal biopsy specimens (four cases) or observed at autopsy (one case) are reported. The spectrum of ultrastructural changes ranging from lamellar and microvesicular phagolysosomal inclusions arranged in a biphasic pattern to fully developed Michaelis-Gutmann bodies is described. In three of the biopsy cases the lesions appeared to represent early stages of malakoplakia lacking classic Michaelis-Gutmann bodies. Especially in this phase of disease, ultrastructural investigation can distinguish between this condition and other histiocytic interstitial renal processes. The findings show that focal cytoplasmic degeneration and autophagolysosomal processes observed in macrophages could precede the disturbance in the process of bacterial breakdown that is responsible for the peculiar granuloma-like inflammatory histiocytic reaction.
Multiple-wave lateral shearing interferometry for wave-front sensing (2005)

Multiple-wave achromatic interferometric techniques are used to measure, with high accuracy and high transverse resolution, wave fronts of polychromatic light sources. The wave fronts to be measured are replicated by a diffraction grating into several copies interfering together, leading to an interference pattern. A CCD detector located in the vicinity of the grating records this interference pattern. Some of these wave-front sensors are able to resolve wave-front spatial frequencies 3 to 4 times higher than a conventional Shack-Hartmann technique using an equivalent CCD detector. Its dynamic is also much higher, 2 to 3 orders of magnitude.
Common radio resource management: functional models and implementation requirements (2005)

Common radio resource management strategies are devoted to achieve an efficient usage of the pool of radio resources available in a heterogeneous radio access network context. This paper describes the functionalities associated with the common vision of radio access technologies, the different possibilities in the functional model split and the corresponding implementation considerations.
Advances in Lipid Nanoparticles for mRNA-Based Cancer Immunotherapy (2020)

Over the past decade, messenger RNA (mRNA) has emerged as potent and flexible platform for the development of novel effective cancer immunotherapies. Advances in non-viral gene delivery technologies, especially the tremendous progress in lipid nanoparticles' manufacturing, have made possible the implementation of mRNA-based antitumor treatments. Several mRNA-based immunotherapies have demonstrated antitumor effect in preclinical and clinical studies, and marked successes have been achieved most notably by its implementation in therapeutic vaccines, cytokines therapies, checkpoint blockade and chimeric antigen receptor (CAR) cell therapy. In this review, we summarize recent advances in the development of lipid nanoparticles for mRNA-based immunotherapies and their applications in cancer treatment. Finally, we also highlight the variety of immunotherapeutic approaches through mRNA delivery and discuss the main factors affecting transfection efficiency and tropism of mRNA-loaded lipid nanoparticles <i>in vivo</i>.
Correlation between rheumatoid factor and IL-6 activity in synovial fluids from patients with rheumatoid arthritis. (1991)

Synovial fluids (SF) and sera (S) from patients with rheumatoid arthritis (RA) were examined for IgM, IgM-rheumatoid factor (IgM-RF), albumin and interleukin-6 (IL-6) activity. The quotient of SF/S IgM-RF was elevated compared with that of SF/S albumin in 7 patients with seropositive RA, although the quotient of SF/S IgM was lower than that of SF/S albumin. SF IL-6 activity was much higher than serum IL-6 activity in all the 7 RA patients. In synovial fluids from 22 seropositive RA patients, SF IL-6 activity was significantly correlated with the SF IgM-RF, IgG-RF and IgA- less than RF, but not with SF IgM, IgG or IgA. Moreover, SF IgM-RF as well as SF IL-6 activity was significantly correlated with the Westergren erythrocyte sedimentation rate (ESR) or the Lansbury articular index. These results indicate that IL-6 and RF might be produced within the rheumatoid joints as a result of abnormal immune system activation, which is associated with the disease activity of RA. Three of the 4 seronegative RA patients, however, showed high SF IL-6 without detectable levels of SF IgM-RF, indicating that IL-6 alone is not sufficient for IgM-RF production.
An assessment of COMPOSER: a rule-based approach to modelling protein structure. (1990)

We describe COMPOSER, a computer program for modelling proteins which uses three-dimensional structures defined by X-ray analysis together with rules defined by their analysis and comparison. We discuss the modelling of phospholipases and serine proteinases of known structure to assess the errors associated with such models.
Rough-set rule induction to build fuzzy time series model in forecasting stock price (2015)

The investment research of stock is an hot issue because it will bring significant returns for investor. The advantages of fuzzy time series can solve the forecast problem in data with linguistic expression. In order to improve fuzzy time-series models, this study direct replaced fuzzy logic relationships with rule-based method to extract fuzzy forecast rules from time series observations. Therefore this paper proposed a rule induction based fuzzy time series model to forecast stock index. In summary, there are four refinements to improve accuracy of forecast: (1) use Miller's magic seven (plus or minus two) to determine the lengths of linguistic intervals, (2) utilize LEM2 algorithm to generate forecast rules, (3) defuzzify the forecast interval based on the generated rules, and (4) use adaptive expectation model to strengthen forecasting performance. For evaluating the proposed model, the practically collected TAIEX stock price from 1998 to 2006 years are used as experimental dataset, and Chen's model, Yu's model, stepwise regression based on ANFIS, and stepwise regression based on support vector regression are compared with the proposed model in RMSE (root mean square error) and profits criteria. The results express that proposed method holds good performance in accuracy.
Commercial Serological Tests for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis: An Updated Systematic Review and Meta-Analysis (2011)

Despite expansion of the literature since 2006, commercial serological tests continue to produce inconsistent and imprecise estimates of sensitivity and specificity. Quality of evidence remains very low. These data informed a recently published World Health Organization policy statement against serological tests. Please see later in the article for the Editors' Summary.
RTMC: an error control protocol for IP-based audio-visual multicast applications (2002)

Transport of audio visual data is becoming an important application of the IP-based best-effort service on the Internet. We present an error control protocol for provision of a real-time reliable multicast transport service. The protocol RTMC (real-time multicast) uses forward error correction (FEC) for protecting first transmissions (i.e. proactive error control) and retransmissions. Results of the performance evaluation show that RTMC error control imposes low latency, and is scalable to a large number of receivers.
Bacterial adherence and biofilm formation on medical implants: A review (2014)

Biofilms are a complex group of microbial cells that adhere to the exopolysaccharide matrix present on the surface of medical devices. Biofilm-associated infections in the medical devices pose a serious problem to the public health and adversely affect the function of the device. Medical implants used in oral and orthopedic surgery are fabricated using alloys such as stainless steel and titanium. The biological behavior, such as osseointegration and its antibacterial activity, essentially depends on both the chemical composition and the morphology of the surface of the device. Surface treatment of medical implants by various physical and chemical techniques are attempted in order to improve their surface properties so as to facilitate bio-integration and prevent bacterial adhesion. The potential source of infection of the surrounding tissue and antimicrobial strategies are from bacteria adherent to or in a biofilm on the implant which should prevent both biofilm formation and tissue colonization. This article provides an overview of bacterial biofilm formation and methods adopted for the inhibition of bacterial adhesion on medical implants.
Does hyaluronic acid stimulate tumor growth after endoscopic mucosal resection? (2008)

We found no evidence that sodium hyaluronate stimulates the growth of remnant tumors after EMR.
Boissier's <i>Tacite</i> - Tacite. Gaston Boissier. Paris : Hachette, 1903. Pp. iv, 343. 3 f. 50. (1904)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
The Rent versus Buy Decision: Investigating the Needed Property Appreciation Rates to be Indifferent between Renting and Buying Property (2012)

This paper investigates the needed property appreciation rates (herein also referred to as hurdle rates, indifference rates, and A's) that make individuals indifferent between owning and renting in 28 markets in the United States. This is done to shed further insight into the buy versus rent decisions currently being faced by consumers of housing. Current hurdle rates are estimated for 23 of the largest metropolitan areas, four directional regions, and the country as a whole. A trend analysis of these hurdle rates is also performed. The findings strongly suggest that with few exceptions U.S. markets are trending towards favoring buying over renting. Said another way, current hurdle rates are below typical property appreciation rates in the markets examined and appear to be trending lower through time.
High-yield manufacturing of InP dual-port coherent receiver photonic integrated circuits for 100G PDM-QPSK application (2011)

We demonstrate a single-chip dual-channel monolithically integrated InP coherent receiver photonic integrated circuit with a shared local oscillator port for application to coherent detection of 100G PDM-QPSK signals. The receiver meets performance specifications for 100G over the entire C-band (1530–1570 nm) measured over a temperature range of 20°C up to 90°C.
An integrated application/service platform to support multimedia applications (2002)

This paper describes a communication support system for multimedia applications relying on the development of an integrated application/service platform. The proposed architecture includes a service platform that provides communication services and their management to multimedia applications and an application platform that provides end-point application services. The former is implemented via an interface re siding at OSI Presentation Service Access Point (PSAP) and the latter via an interface residing at OSI Application Service Access Point (ASAP). It is anticipated that the combination of the proposed integrated application/service platform will ensure the interoperability among existing and future multimedia applications within the broadband environment. It is widely accepted that the key requirement for a multimedia application is the availability of a distributed multimedia environment. Multimedia applications could be distinguished as interactive or non-interactive such as conferencing and video-on-demand, respectively, and impose specific requirements to be met, i.e. synchronization of isochronous streams, end-to-end delay constraints and multicast transmissions. In this paper we propose an enhanced protocol/service structure that overcomes the weaknesses of the conventional OSI Reference Model. The result of this approach is an application/service platform that provides a QoS support throughout all OSI upper layers. Finally, adaptations of OSI elements are proposed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Vascular endothelial growth factor and the <i>in vivo</i> increase in plasma extravasation in the hamster cheek pouch (2001)

1. The purpose of this study in the hamster cheek pouch was to determine whether or not vascular endothelial growth factor (VEGF) induced changes in plasma extravasation and if so, the mechanism(s) involved. 2. The cheek pouch microcirculatory bed of the anaesthetized hamster was directly observed under microscope and the number of vascular leakage sites, as shown by fluorescein isothiocyanate (FITC-dextran, 150 kD) extravasation, was counted. Drugs and VEGF were applied topically. VEGF from 0.05 to 0.5 microg ml(-1) (1.2 to 12 nM) produced a dose-dependent increase in the number of microvascular leakage sites from virtually none in basal conditions to up to 250 in some pouches. The effects of VEGF (0.1 microg ml(-1) or 2.4 nM) were blocked in a concentration-dependent manner by the non-specific heparin growth factor antagonist TBC-1635 (0.1, 1 and 3microM). The placenta growth factor (PlGF-1: 0.1 and 0.5 microg ml(-1) or 3.4 and 17 nM) did not increase plasma extravasation, per se, but abolished the effects of VEGF (2.4 nM). 3. The increases in microvascular leakage produced by VEGF (2.4 nM) were partially but significantly (P<0.05) inhibited by genistein (5 and 10 microM, up to 33% inhibition), LY 294002 (30 microM, 41%), bisindolylmaleimide (1 microM, 65%) and virtually abolished by indomethacin (3 microM, 88%) and L-nitro-arginine (10 microM, 95%), these drugs being inhibitors of tyrosine kinase, phosphatidylinositol-3-kinase, protein kinase C, cyclo-oxygenase and nitric oxide synthase respectively. None of these inhibitors, at the concentration tested, induced alone an increase in plasma extravasation. 4. These results indicate that the VEGF-induced plasma extravasation may involve the stimulation of VEGF-R2 (Flk-1/KDR) and the activation of phosphatidylinositol-3-kinase and protein kinase C. The production of both nitric oxide and prostaglandin is required to observe an increase in vascular leakage.
MATCHING NETWORK USING ONE CONTROL ELEMENT FOR WIDELY TUNABLE ANTENNAS (2012)

A tunable impedance matching network is applied to achieve very widely tunable antennas, whose geometries are indepen- dent and unchanged to simplify the design. The attached matching network as the antenna feeding network enables any unspecifled UWB antenna to tune the operation frequency continuously with high se- lectivity by merely one single control. This is quite difierent from fllter-based concept which is complicated to co-design and implement a tiny narrow band tunable fllter over wide frequency ranges and very di-cult to control with one element. And also the design, adjustment, and optimization of the matching network are much simpler, quicker, and lower cost than geometry-modifled antenna design. The analysis of precise high frequency circuit models is used predict the perfor- mance in simulation. Fabricated prototype antennas are measured by using horn antennas to validate the antenna performance. The tun- able frequency ranges from 1.8GHz to 2.8GHz (155%) and 2.19GHz to 3.86GHz (176%). Moreover, compared to other matching network- based solutions, non-ideal efiects in undesired bands other than the operation frequency band are suppressed, so the performance is im- proved. One wide-tuning antenna using one single element to control can be carried out by tunable matching networks without complicated designs.
Collaborative Study of a Proposed International Standard for Plasma Fibrinogen Measurement (1992)

There is increased interest in the relationship between plasma fibrinogen levels and the incidence of coronary artery disease. The National Institute for Biological Standards and Control (UK) has completed a study to establish an International Standard for plasma fibrinogen. This study was conducted using a recommended assay procedure to measure the clottable material present in the proposed lyophilised Standard (coded 89/644). Twenty-two laboratories from nine countries took part in the study and analysis of the data allowed the calibration of 89/644 at 2.4 mg/ml clottable protein. Agreement with this figure was established in two laboratories using three or more different assays for plasma fibrinogen. Degradation studies of the proposed plasma fibrinogen Standard suggested that no loss of clottable protein was observed when the lyophilised material was stored at 20 degrees C for 1 year. The Fibrinogen Sub-Committee of the ISTH (Amsterdam, The Netherlands, June 1991) supported the establishment of 89/644 as an International Standard. This collaborative study will be presented to the Expert Committee on Biological Standardisation of the World Health Organisation at their 1992 session. In the meantime 89/644 will be distributed as the proposed International Standard for plasma fibrinogen measurement containing 2.4 mg/ml clottable protein.
Isolation and Characterization of Glutathione Biosynthesis-deficient Mutants in<i>Saccharomyces cerevisiae</i> (1990)

Saccharomyces cerevisiae YNN27 (MATα, trp1 ura3 gal2) was mutagenized with ethyl methanesulfonate to isolate mutants deficient in glutathione biosynthesis. After mutants sensitive to 6.5 mm methylglyoxal were screened for, 12 glutathione biosynthesis-deficient mutants were isolated. Complementation tests found that the 12 mutants were classified into two different classes (YH1, YL1), and that each mutant was recessive and had a single mutation in glutathione biosynthesis. The growth of both strains in minimal medium was slower than that of the parent strain and was restored to the wild type level by supplementation with glutathione. They were also more sensitive to some chemicals such as thiol-reactive agents and metal-chelating agents than the parent strain. The mutant strain YL1 lacked activity of glutathione synthetase, while the deficiencies in γ-glutamylcysteine synthetase in mutant strains YH1 and YL1 were equivocal because the activity of the parent strain was very weak. However, supplementation with glutathione component amino acids and γ-glutamylcysteine to the medium showed that strain YH1, but not YL1, was deficient in γ-glutamylcysteine synthetase.
Model Peptides Based on the Binding Loop of the Copper Metallochaperone Atx1:  Selectivity of the Consensus Sequence MxCxxC for Metal Ions Hg(II), Cu(I), Cd(II), Pb(II), and Zn(II) (2006)

The amino acid sequence MxCxxC is conserved in many soft-metal transporters that are involved in the control of the intracellular concentration of ions such as Cu(I), Hg(II), Zn(II), Cd(II), and Pb(II). A relevant task is thus the selectivity of the motif MxCxxC for these different metal ions. To analyze the coordination properties and the selectivity of this consensus sequence, we have designed two model peptides that mimic the binding loop of the copper chaperone Atx1: the cyclic peptide P(C) c(GMTCSGCSRP) and its linear analogue P(L) (Ac-MTCSGCSRPG-NH2). By using complementary analytical and spectroscopic methods, we have demonstrated that 1:1 complexes are obtained with Cu(I) and Hg(II), whereas 1:1 and 1:2 (M:P) species are successively formed with Zn(II), Cd(II), and Pb(II). The complexation properties of the cyclic and linear peptides are very close, but the cyclic compound provides systematically higher affinity constants than its unstructured analogue. The introduction of a xPGx motif that forms a type II beta turn in P(C) induces a preorganization of the binding loop of the peptide that enhances the stabilities of the complexes (up to 2 orders of magnitude difference for the Hg complexes). The affinity constants were measured in the absence of any reducing agent that would compete with the peptides and range in the order Hg(II) > Cu(I) >> Cd(II) > Pb(II) > Zn(II). This sequence is thus highly selective for Cu(I) compared to the essential ion Zn(II) that could compete in vivo or compared to the toxic ions Cd(II) and Pb(II). Only Hg(II) may be an efficient competitor of Cu(I) for binding to the MxCxxC motif in metalloproteins.