gebhart/patrepeval huggingface dataset:
Expanding baculovirus surface display (2000)

To create a tool for eukaryotic surface display, this approach is aimed at demonstrating a direct modification of the native envelope protein gp64 of Autographa californica NPV without disturbing viral infectivity. Short affinity-tag peptides, the biotin mimic streptagII, and the gp41 amino-acid motif ELDKWA of HIV-1, specific for the human monoclonal antibody 2F5, were engineered into the baculovirus major coat protein gp64 and presented on the viral surface. Two different streptag peptides were inserted at the naturally occurring NotI site at amino-acid 278 of gp64. Additionally, the ten-amino-acid peptide GG-ELDKWA-GG, containing the epitope of mAb 2F5, was introduced into gp64 envelope protein at the same position. In all cases we were able to propagate viable virus-achieving infectious titers in the range of wild-type AcMNPV. Streptag and ELDKWA-epitope surface localization on purified virus particles was demonstrated by flow cytometry and Western blot analysis. We could also show selective retention of mutant viruses by specific interaction between chimeric virions and their target counterparts, recognizing the epitope or the streptag peptide in the viral envelope. These data provide evidence that altering the surface properties of the baculovirus virion could be of value in improving baculovirus display technology and developing new applications.
The Role of Exciton Ionization Processes in Bulk Heterojunction Organic Photovoltaic Cells (2015)

To realize efficient photoconversion in organic semiconductors, photogenerated excitons must be dissociated into their constituent electronic charges. In an organic photovoltaic (OPV) cell, this is most often accomplished using an electron donor–acceptor (D–A) interface. Interestingly, recent work on MoO x /C 60 Schottky OPVs has demonstrated that excitons in C 60 may also undergo efficient bulk‐ionization and generate photocurrent as a result of the large built‐in field created by the MoO x /C 60 interface. Here, it is demonstrated that bulk ionization processes also contribute to the short‐circuit current density ( J SC ) and open‐circuit voltage ( V OC ) in bulk heterojunction (BHJ) OPVs with fullerene‐rich compositions. Temperature‐dependent measurements of device performance are used to distinguish dissociation by bulk‐ionization from charge transfer at the D–A interface. In optimized fullerene‐rich BHJs based on the D–A pairing of boron subphthalocyanine chloride (SubPc)–C 60 , bulk‐ionization is found to be responsible for ≈16% of the total photocurrent, and >30% of the photocurrent originating from C 60 . The presence of bulk‐ionization in C 60 also impacts the temperature dependence of V OC , with fullerene‐rich SubPc:C 60 BHJ OPVs showing a larger V OC than evenly mixed BHJs. The prevalence of bulk‐ionization processes in efficient, fullerene‐rich BHJs underscores the need to include these effects when engineering device design and morphology in OPVs.
(−)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic Acid [(−)DRF 2725]:  A Dual PPAR Agonist with Potent Antihyperglycemic and Lipid Modulating Activity (2001)

(-)DRF 2725 (6) is a phenoxazine analogue of phenyl propanoic acid. Compound 6 showed interesting dual activation of PPAR alpha and PPAR gamma. In insulin resistant db/db mice, 6 showed better reduction of plasma glucose and triglyceride levels as compared to rosiglitazone. Compound 6 has also shown good oral bioavailability and impressive pharmacokinetic characteristics. Our study indicates that 6 has great potential as a drug for diabetes and dyslipidemia.
Effects of Silicon Nitride Encapsulation on MOS Device Stability (1980)

A new threshold instability phenomenon has been observed in Sigate MOS transistors encapsulated with plasma deposited silicon nitride films. The saturation mode threshold has been observed to drift as much as -0.5V when the MOSFET is operating with high drain voltage. Through a series of experiments it is concluded that this instability is due to a chemical effect associated with hydrogen in the nitride films. The formation of surface states and fixed charges in the channel region due to the-interaction of hot carriers with hydrogen present at the interface is proposed to be the basic mechanism. Experimental results with respect to voltage, time and device geometry, will be discussed.
ChemInform Abstract: REACTIONS OF SULFOXIDE‐THIOETHER BIDENTATE LIGANDS WITH PLATINUM(II). DETERMINATION OF THE MODE OF BINDING BY CYCLIC VOLTAMMETRY (1985)

Abstract Die cyclische Voltammetrie wird zur Untersuchung der Bindungsart von 1,4‐Dithiacyclohexan‐1‐oxid an Pt(II) benutzt.
The Assessment of Machine Learning Model Performance for Predicting Alluvial Deposits Distribution (2014)

This paper discusses the development and evaluation of distribution models for predicting alluvial mineral potential mapping. A number of existing models includes Weight of Evidence, Knowledge-driven Fuzzy, Data-driven Fuzzy, Neural-Network, Bayesian Classifier and Geostatistical Kriging. We offer classification models developed in our laboratory, where point pattern analysis was used to identify presence or absence of a known secondary alluvial (cassiterite) deposits in the Nigerian Younger Granite Region (NYGR) and the model performance assessed. We focused on the training and testing data split using longitudinal spatial data splitting (strips and halves) to ensure predictive attribute's independence. The spatial data split runs counter to the traditional random sample data selection as a procedure for checking overfitting of models mainly due to spatial data autocorrelation. Specifically, we used classification algorithms such as; Naive Bayes, Support Vector Machine, K-Nearest Neighbour, Decision Tree Bagging and Discriminant Analysis algorithms for training and testing. We analysed the model's performance results using model predictive accuracy and ROC curve values in two different approaches that improve spatial data independence among predictive attributes to give a meaningful model performance.
Grip-Pattern Recognition for Smart Guns (2003)

Abstract — This paper describes the design, implementation and evaluation of a user-verification system for a smart gun, which is based on grip-pattern recognition. An existing pressure sensor consisting of an array of 44 × 44 piezoresistive elements has been used. An interface has been developed to acquire pressure images from the sensor. The values of the pixels in the pressure-pattern images are used as inputs for a verification algorithm, which is currently implemented in software on a computer. The verification algorithm is based on a likelihood-ratio classifier for Gaussian probability densities. First results indicate that it is possible to use grip-pattern recognition for biometric verification, when allowing a certain false-rejection and false-acceptance rate. However, more measurements are needed to give a more reliable indication of the system’s performance. Keywords—biometric verification, likelihood ratio, smart gun, grip-pattern recognition I.
The threat of chemical and biological terrorism: preparing a response (2002)

When a deadly contaminant is released in a city, the window of time for meaningful response is brief. High-performance computing can play a major role in preparing an effective response. This article describes one such effort, which exploits detailed 3D computational fluid dynamics simulations of the airflow in buildings and cities.
Evolution and utility of a Pseudomonas aeruginosa drug resistance factor (1976)

We describe the addition to the Pseudomonas aeruginosa sex factor, FP2, of carbenicillin resistance encoded by the RP1 plasmid. This occurred in a step-wise manner as detected by variations in the characteristics of the FP2-RP1 plasmid aggregate. The addition of the carbenicillin resistance marker to FP2 facilitates estimates of FP2 transfer. Transfer frequencies for the presumed cointegrate plasmid, using carbenicillin selection, approached 10(-1) per donor bacterium. The chromosomal mobilization properties of the derived plasmid, designated pR0271, resembled those of the progenitor plasmid FP2. Plasmid pR0271 was also observed to mobilize a nontransmissible drug resistance plasmid sharing genetic homology at frequencies corresponding to those observed for chromosomal markers proximal to the origin of transfer.
Ultrafast refractive index dynamics in AlGaAs diode laser amplifiers (1991)

Ultrafast refractive index dynamics in AlGaAs diode laser amplifiers were studied using 440 fs optical pulses. Refractive index changes consistent with a free carrier heating model proposed to explain earlier studies of gain dynamics in diode lasers are exhibited. We also observe an apparently instantaneous refractive index change that corresponds to an n2⊥ of −5×10−12 cm2/W.
Differentially Private Mixture of Generative Neural Networks (2017)

Generative models are used in an increasing number of applications that rely on large amounts of contextually rich information about individuals. Owing to possible privacy violations, however, publishing or sharing generative models is not always viable. In this paper, we introduce a novel solution for privately releasing generative models and entire high-dimensional datasets produced by these models. We model the generator distribution of the training data by a mixture of k generative neural networks. These are trained together and collectively learn the generator distribution of a dataset. Data is divided into k clusters, using a novel differentially private kernel k-means, then each cluster is given to separate generative neural networks, such as Restricted Boltzmann Machines or Variational Autoencoders, which are trained only on their own cluster using differentially private gradient descent. We evaluate our approach using the MNIST dataset and a large Call Detail Records dataset, showing that it produces realistic synthetic samples, which can also be used to accurately compute arbitrary number of counting queries.
Si diffusion and intermixing in AlGaAs/GaAs structures using buried impurity sources (1995)

Si diffusion and impurity-induced layer intermixing from a buried impurity source have been studied by transmission electron microscopy and secondary ion mass spectroscopy of isolated, Si-doped GaAs layers in an undoped Al0.4Ga0.6As/GaAs superlattice and by photoluminescence measurements on Si-doped GaAs quantum wells with undoped Al0.4Ga0.6As barriers. In annealed samples, the Si profile suggests a Si diffusion process involving multiply ionized column III vacancies. The width of the resulting Si profile and the spatial extent and completeness of intermixing strongly depend on the initial Si concentration in the doped layer.
Earthquake Prediction by Animals: Evolution and Sensory Perception (2000)

Animals living within seismically active regions are subjected episodically to intense ground shaking that can kill individuals through burrow collapse, egg destruction, and tsunami action. Although anecdotal and retrospective reports of animal behavior suggest that although many organisms may be able to detect an impending seismic event, no plausible scenario has been presented yet through which accounts for the evolution of such behaviors. The evolutionary mechanism of exaptation can do this in a two-step process. The first step is to evolve a vibration-triggered early warning response which would act in the short time interval between the arrival of P and S waves. Anecdotal evidence suggests this response already exists. Then if precursory stimuli also exist, similar evolutionary processes can link an animal's perception of these stimuli to its P-wave triggered response, yielding an earthquake predictive behavior. A population-genetic model indicates that such a seismic-escape response system can be maintained against random mutations as a result of episodic selection that operates with time scales comparable to that of strong seismic events. Hence, additional understanding of possible earthquake precursors that are presently outside the realm of seismology might be gleaned from the study of animal behavior, sensory physiology, and genetics. A brief review of possible seismic precursors suggests that tilt, hygroreception (humidity), electric, and magnetic sensory systems in animals could be linked into a seismic escape behavioral system. Several testable predictions of this analysis are discussed, and it is recommended that additional magnetic, electrical, tilt, and hygro-sensors be incorporated into dense monitoring networks in seismically active regions.
Inside XML DTDs (1999)

From the Publisher:
The Extensible Markup Language (XML) is today's most exciting new format for transferring data across the World Wide Web and other networks.. Focusing on the nuts and bolts of XML, Inside XML DTDs is the first and only complete guide to creating, using, and updating document type definitions (DTDs), which provide a layer of additional power on top of the document structures built into XML and enable documents to share large chunks of information.. Included is a value-packed CD-ROM containing DTDs discussed in the book, sample documents, and browsers.
Steaming multiwalled carbon nanotubes via acid vapour for controllable nanoengineering and the fabrication of carbon nanoflutes (2011)

A new concept of steaming multiwalled carbon nanotubes (MWCNTs) via acid vapour was presented for controllable nanoengineering of the MWCNTs. This method is more simple, effective, precisely-controllable and environmentally-friendly compared to traditional ones. Moreover, novel porous carbon nanotubes, named carbon nanoflutes, were fabricated based on this strategy.
Chapter 24. Magnetism (1994)

A. Harrison and A. S. Wills, Annu. Rep. Prog. Chem., Sect. A: Inorg. Chem., 1994, 91, 437 DOI: 10.1039/IC9949100437
Terpenoids from bark beetles, solitary bees and danaine butterflies (1989)

Abstract
Modulators of the urokinase-type plasminogen activation system for cancer (2010)

The multifunctional potential of the uPA system in cancer has rendered this system an attractive novel target for anticancer therapy. A few novel tumor biology-based therapeutic strategies reported here, opening new ways for patient-optimized and individualized cancer therapy. It may be the right time to evaluate the hypothesis that the uPA system plays a pivotal role in cancer progression and that targeting this system will lead to clinical benefit in cancer patients.
Dynamic resource allocation and power management in virtualized data centers (2010)

We investigate optimal resource allocation and power management in virtualized data centers with time-varying workloads and heterogeneous applications. Prior work in this area uses prediction based approaches for resource provisioning. In this work, we take an alternate approach that makes use of the queueing information available in the system to make online control decisions. Specifically, we use the recently developed technique of Lyapunov Optimization to design an online admission control, routing, and resource allocation algorithm for a virtualized data center. This algorithm maximizes a joint utility of the average application throughput and energy costs of the data center. Our approach is adaptive to unpredictable changes in the workload and does not require estimation and prediction of its statistics.
Anti-hyperlipidemic and hypoglycemic effects of Gynostemma pentaphyllum in the Zucker fatty rat. (2006)

Gynostemma pentaphyllum is a traditional Chinese medicine used for a variety of conditions, including elevated cholesterol. We have examined the pharmacological anti-hyperlipidemic and hypoglycemic effectiveness of Gynostemma pentaphyllum in the obese Zucker fatty diabetic rat model. After treatment for 4 days Gynostemma pentaphyllum 250 mg/kg reduced triglyceride (33%), total cholesterol, (13%) and low density lipoprotein cholesterol levels (33%). These effects were dose-dependent and maintained for at least 5 weeks. Chronic treatment for 3-5 weeks also reduced post-prandial hypertriglyceridemia induced by olive oil 10 mg/kg in the Zucker fatty rats but had no significant effect in lowering sucrose-induced hyperglycemia in Sprague-Dawley rats. A novel regulation by Gynostemma of glucose levels was also observed in the Zucker fatty rat model. In a glucose tolerance test in obese and lean Zucker rats pretreatment with Gynostemma pentaphyllum 250 mg/kg demonstrated glucose levels were significantly less 2 hours post challenge (20%) in the Gynostemma pentaphyllum obese rats compared to the control group. Gynostemma pentaphyllum did not significantly reduce glucose levels at 120 min in the lean strain, in contrast to the 20% decrease seen in the obese rat. In vitro, Gynostemma pentaphyllum inhibited alpha-glucosidase activity (50% inhibition at 42.8), which compared to acarbose (50% at 53.9 microg/mL). The improvement in glucose tolerance at 120 min by Gynostemma pentaphyllum in obese Zucker fatty rats but not lean rats suggests that it may improve insulin receptor sensitivity and together with the significant reduction of hypertriglyceridemia, cholesterol and low density lipoprotein cholesterol suggests that Gynostemma should be examined further by oral hypoglycemic/anti-hyperlipidemic therapy.
Regulation of a Viral Proteinase by a Peptide and DNA in One-dimensional Space (2012)

Late in an adenovirus infection, the viral proteinase (AVP) becomes activated to process virion precursor proteins used in virus assembly. AVP is activated by two cofactors, the viral DNA and pVIc, an 11-amino acid peptide originating from the C terminus of the precursor protein pVI. There is a conundrum in the activation of AVP in that AVP and pVI are sequence-independent DNA-binding proteins with nm equilibrium dissociation constants such that in the virus particle, they are predicted to be essentially irreversibly bound to the viral DNA. Here, we resolve that conundrum by showing that activation of AVP takes place on the one-dimensional contour of DNA. In vitro, pVI, a substrate, slides on DNA via one-dimensional diffusion, D(1) = 1.45 × 10(6) bp(2)/s, until it binds to AVP also on the same DNA molecule. AVP, partially activated by being bound to DNA, excises pVIc, which binds to the AVP molecule that cut it out. pVIc then forms a disulfide bond with AVP forming the fully active AVP-pVIc complex bound to DNA. In vivo, in heat-disrupted immature virus, AVP was also activated by pVI in DNA-dependent reactions. This activation mechanism illustrates a new paradigm for virion maturation and a new way, by sliding on DNA, for bimolecular complexes to form among proteins not involved in DNA metabolism.
PorB2/3 Protein Hybrid in<i>Neisseria meningitidis</i> (2008)

DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.
Scrambling Techniques for CDMA Communications (2002)

Scrambling Techniques for CDMA Communications addresses spreading, scrambling, and synchronization techniques for use in inter-cell synchronous and asynchronous CDMA systems, including the IMT-2000. It provides fundamental background material for sequences and shift register generators, and demonstrates various acquisition techniques in primitive, advanced levels, and in the third generation (3G) DS/CDMA cellular systems. In addition, it introduces the novel acquisition techniques DSA (Distributed Sample Acquisition) and CDMA (Correlation-aided DSA) that enable rapid and robust acquisition of inter-cell synchronous and asynchronous IMT-2000 CDMA systems. Scrambling Techniques for CDMA Communications will be invaluable to wireless communication engineers, and in particular those involved in theoretical and design works related to spreading, scrambling, and synchronization of CDMA communication systems
Benefits of EDC and linear receivers for short reach 40/100GE (2008)

An ongoing trend in datacom switches is to require optical transceivers to be smaller and have lower power dissipation in order to enable greater port densities. The transition from 1 GE to 10 GE was unusually slow for the Ethernet market due in part to the high cost. high power dissipation, and form factor of the optical module. The industry is now overcoming these hurdles with the transition to SFP + modules, which will enable more traditional Ethernet growth. Upcoming 40 GE and 100 GE are multilane protocols, presenting even greater challenges than 10 GE laced at its inception, potentially slowing their adoption. Leveraging SFP+ class technology such as simple EDC capabilities can lower cost and reduce module form factors, thus accelerating the transition to 40/100 GE interlace deployment.
A Decade of Aflatoxin M1 Surveillance in Milk and Dairy Products in Developing Countries (2001-2011): A Review (2013)

A Decade of Aflatoxin M1 Surveillance in Milk and Dairy Products in Developing Countries (2001-2011): A Review
Removal of viable sheets of conjunctival epithelium with dispase II. (1985)

A technique (based on Gipson and Grill, Invest Ophthalmol Vis Sci 23:269, 1982) has been developed to obtain pure, viable, intact sheets of rabbit conjunctival epithelium free of the underlying basement membrane. After preparing a full thickness eye wall resection, Dispase, grade II (neutral protease-Bacillus polymyxa), 1.2 Units/ml MEM is injected intrasclerally. The conjunctiva and sclera are pinned in agar and incubated in the dispase with MEM for 1 hour. A 2 X 3 mm sheet of conjunctival epithelium can be dissected bluntly. Light microscopy shows a two- to three-layered epithelium with many goblet cells. Transmission electron microscopy reveals blebbing at the freed basal epithelial cell membrane, intact desmosomes, and intact goblet cells. The conjunctival sheets were cultured on epithelial-scraped corneal stromal carriers in vitro. Numerous goblet cells were present up to 12 hours on 4-mm carriers and 24 hours on 1-mm carriers. With this technique, pure populations of conjunctival epithelium can be isolated for further characterization and tissue culture.
A theory of withdrawal of cylinders from liquid baths (1966)

Abstract A theory of the amount of liquid entrained by cylinders upon withdrawal from liquid baths is derived for a wide range of cylinder radii. The theory is based on matching curvatures for static and dynamic menisci. Predicted values are expressed as the effect of the dimensionless wire radius (Goucher number) and dimensionless withdrawal speed (capillary number) on the dimensionless flux. The theory was verified experimentally for all wire radii by removing short cylinders from oily fluids and with other information. The fluids used included kerosene, mineral oil, motor oil, and glycerine, with viscosities from 2 to 500 centipoise; Goucher numbers ranged from 0.05 to 1.2. Deviations, which were noted at high capillary numbers where velocity gradients become appreciable, indicated that the theory is a plug flow or low speed theory. Also discussed are differences found with water and the conditions under which films coalesced into droplets.