gebhart/patrepeval huggingface dataset:
A Liquid Calorimeter for High-Energy Lasers (1963)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text E. K. Damon and J. T. Flynn, "A Liquid Calorimeter for High-Energy Lasers," Appl. Opt. 2, 163-164 (1963) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Tumor necrosis factor-α regulation of CD4<sup>+</sup>C25<sup>+</sup>T cell levels in NOD mice (2002)

The mechanism by which tumor necrosis factor-alpha (TNF) differentially modulates type I diabetes mellitus in the nonobese diabetic (NOD) mouse is not well understood. CD4+CD25+ T cells have been implicated as mediators of self-tolerance. We show (i) NOD mice have a relative deficiency of CD4+CD25+ T cells in thymus and spleen; (ii) administration of TNF or anti-TNF to NOD mice can modulate levels of this population consistent with their observed differential age-dependent effects on diabetes in the NOD mouse; (iii) CD4+CD25+ T cells from NOD mice treated neonatally with TNF show compromised effector function in a transfer system, whereas those treated neonatally with anti-TNF show no alteration in ability to prevent diabetes; and (iv) repeated injection of CD4+CD25+ T cells into neonatal NOD mice delays diabetes onset for as long as supplementation occurred. These data suggest that alterations in the number and function of CD4+CD25+ T cells may be one mechanism by which TNF and anti-TNF modulate type I diabetes mellitus in NOD mice.
Distribuição do teor de sólidos solúveis totais no melão (2003)

Determinou-se o teor de sólidos solúveis totais (TSST) em frutos do meloeiro amarelo (Cucumis melo L.). Dois experimentos foram realizados com as mesmas cultivares (AF-646, Gold Mine, Gold Pride, Rochedo, Goldex), em duas épocas. No primeiro, determinou-se o TSST nas porções basal (próxima ao pedúnculo), mediana e apical e no segundo, nas porções ventral (porção do fruto em contato com o solo), lateral e dorsal. Utilizou-se o delineamento de blocos ao acaso com parcelas subdivididas e três repetições. As cultivares constituíram as parcelas e as porções do fruto, as subparcelas. Três frutos de cada parcela foram divididos nas porções mencionadas, descascados e a polpa triturada em processador doméstico. O material foi filtrado em tecido de nylon e três determinações do TSST, em refratômetro digital, foram feitas no suco obtido. No primeiro experimento, houve efeito apenas do fator porção, sendo que os TSST das porções mediana (9,53ºB) e apical (9,48ºB) não diferiram entre si e foram superiores ao da porção basal (8,66ºB). No segundo experimento, houve efeito de cultivares (C) e de porções (P), mas não da interação C x P. A cultivar Goldex apresentou o maior teor (10,03ºB) e a cultivar AF-646, o menor (8,11ºB). As porções ventral (8,94ºB) e dorsal (9,07ºB) não diferiram entre si e foram superiores à lateral (8,69ºB).
Texture analysis of tissue surrounding microcalcifications on mammograms for breast cancer diagnosis (2007)

Diagnosis of microcalcifications (MCs) is challenged by the presence of dense breast parenchyma, resulting in low specificity values and thus in unnecessary biopsies. The current study investigates whether texture properties of the tissue surrounding MCs can contribute to breast cancer diagnosis. A case sample of 100 biopsy-proved MC clusters (46 benign, 54 malignant) from 85 dense mammographic images, included in the Digital Database for Screening Mammography, was analysed. Regions of interest (ROIs) containing the MCs were pre-processed using a wavelet-based contrast enhancement method, followed by local thresholding to segment MCs; the segmented MCs were excluded from original image ROIs, and the remaining area (surrounding tissue) was subjected to texture analysis. Four categories of textural features (first order statistics, co-occurrence matrices features, run length matrices features and Laws' texture energy measures) were extracted from the surrounding tissue. The ability of each feature category in discriminating malignant from benign tissue was investigated using a k-nearest neighbour (kNN) classifier. An additional classification scheme was performed by combining classification outputs of three textural feature categories (the most discriminating ones) with a majority voting rule. Receiver operating characteristic (ROC) analysis was conducted for classifier performance evaluation of the individual textural feature categories and of the combined classification scheme. The best performance was achieved by the combined classification scheme yielding an area under the ROC curve (A(z)) of 0.96 (sensitivity 94.4%, specificity 80.0%). Texture analysis of tissue surrounding MCs shows promising results in computer-aided diagnosis of breast cancer and may contribute to the reduction of unnecessary biopsies.
Development and assessment of a biodegradable solvent cast polyester fabric small‐diameter vascular graft (2013)

Adjusting the mechanical properties of polyester-based vascular grafts is crucial to achieving long-term success in vivo. Although previous studies using a fabric-based approach have achieved some success, a central issue with pure poly(lactic acid) (PLA) or poly(glycolic acid) (PGA) grafts sealed with poly(DL-caprolactone-co-lactic acid) (P(CL/LA)) has been stenosis. Intimal hyperplasia, a leading cause of stenosis, can be caused by the mechanical incompatibility of synthetic vascular grafts. Investigating the performance of poly(glycolic-co-lactic acid) (PGLA) grafts could lead to insight into whether graft stenosis stems from mechanical issues such as noncompliance and unfavorable degradation times. This could be achieved by examining grafts with tunable mechanical properties between the ranges of such properties in pure PGA and PLA-based grafts. In this study, we examined PGLA-based grafts sealed with different P(CL/LA) solutions to determine the PGLA-P(CL/LA) grafts' mechanical properties and tissue functionality. Cell attachment and proliferation on graft surfaces were also observed. For in vivo assessment, grafts were implanted in a mouse model. Mechanical properties and degradation times appeared adequate compared to recorded values of vessels used in autograft procedures. Initial neotissue formation was observed in the grafts and patency maintained during the pilot study. This study presents a ∼1-mm diameter degradable graft demonstrating suitable mechanical properties and in vivo pilot study success, enabling further investigation into the tuning of mechanical properties to reduce complications in degradable polyester fabric-based vascular grafts.
La pena de muerte en el sistema de los fines de la pena (2003)

Tan solo cien de los ciento noventa y cuatro Estados del mundo han suprimido la pena de muerte tras la declaracion de la organizacion de derechos humanos Amnistia Internacional. Por lo que respecta a las democracias occidentales, unicamente en los Estados Unidos de Norteamerica se conserva, todavia, la pena de muerte en treinta y ocho de los cincuenta Estados de la Union en los casos de comision de delitos graves1 . Mexico ocupa ciertamente un lugar especial, ya que el articulo 22 en relacion con el articulo 73, fraccion 21, de la Constitucion Politica de los Estados Unidos Mexicanos conserva la pena de muerte contemplando su regulacion mediante ley ordinaria, es decir, sin reforma consti tucional y LA PENA DE MUERTE EN EL SISTEMA DE LOS FINES DE LA PENA* ** CHRISTIAN JAGER
Cultivation and utilization of aromatic plants (1982)

Cultivation and utilization of aromatic plants , Cultivation and utilization of aromatic plants , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Automated Audio-visual Activity Analysis (2005)

Current computer vision techniques can effectively monitor gross activities in sparse environments. Unfortunately, visual stimulus is often not sufficient for reliably discriminating between many types of activity. In many cases where the visual information required for a particular task is extremely subtle or non-existent, there is often audio stimulus that is extremely salient for a particular classification or anomaly detection task. Unfortunately unlike visual events, independent sounds are often very ambiguous and not sufficient to define useful events themselves. Without an effective method of learning causally-linked temporal sequences of sound events that are coupled to the visual events, these sound events are generally only useful for independent anomalous sounds detection, e.g., detecting a gunshot or breaking glass. This paper outlines a method for automatically detecting a set of audio events and visual events in a particular environment, for determining statistical anomalies, for automatically clustering these detected events into meaningful clusters, and for learning salient temporal relationships between the audio and visual events. This results in a compact description of the different types of compound audio-visual events in an environment. 1.
Searching for the Achilles Heel of FOXP3 (2013)

FOXP3 is a multifaceted transcription factor with a major role in the control of immune homeostasis mediated by T regulatory cells (Treg). The immunoregulatory function of FOXP3 may hinder the induction of immune responses against cancer and infectious agents, and thus, development of inhibitors of its functions might give new therapeutic opportunities for these diseases. But also, FOXP3 is an important tumor suppressor factor in some types of cancers, and therefore, understanding the structure and function of FOXP3 is crucial to gaining insights into the development of FOXP3-targeted therapeutic strategies. FOXP3 homodimerize and likely form supramolecular complexes which might include hundreds of proteins which constitute the FOXP3 interactome. Many of the functions of FOXP3 are clearly regulated by the interactions with these cofactors contributing importantly on the establishment of Treg-cell signature. We summarize here the structural/functional information on this FOXP3 complex, to identify potential opportunities for the development of new strategies to modulate FOXP3 activity.
Improved synthesis of 14-methyl-1-octadecene, the sex pheromone of the peach leafminer moth. (1985)

Recently, 14-methyl-l-octadecene 1 has been isolated and identified1} as the sex pheromone of the peach leafminer moth, Lyonetia clerkella Linne, which is one of the most destructive pests in peach orchards in Japan. The
Molecular cloning and sequence analysis of chum salmon gonadotropin cDNAs. (1989)

cDNAs encoding alpha and beta subunits of salmon gonadotropins, sGTHI and sGTHII, have been isolated from the cDNA library prepared from salmon pituitary mRNA. sGTHI alpha, sGTHI beta, and sGTHII beta cDNAs encode polypeptides of 114, 137, and 142 amino acids, including signal peptides of 22, 24, and 23 amino acids, respectively. The deduced amino acid sequence for sGTHI alpha revealed rather high homology (66-69%) to mammalian alpha chains, whereas sGTHI beta and sGTHII beta show lower homology (30%) to each other and to mammalian beta subunits. The existence of two distinct beta-subunit cDNAs in the teleost suggests that divergence of the GTH gene took place earlier than divergence of teleosts from the main line of evolution leading to tetrapods.
Primary spinal melanoma: illustrative case (2021)

Resection is the treatment of choice, with some authors advocating for postoperative chemotherapy, immunotherapy, and/or radiation. We describe a case of acute quadriplegia from hemorrhagic primary spinal melanoma requiring resection.
The theoretical model of optical waveguide impulse response (2005)

From the known transfer function of optical propagation, its impulse response function has been derived out. The resulted diffraction formula, which needn't be based upon the assumption of the Sommerfeld radiation condition and can then be applied to any infinite wave front case, shows the complete equivalence of the diffraction theory of Fourier optics with the Sommerfeld's scalar diffraction theory. The existence of the general cross radiation condition, which closely depends on the specific Green function employed by Sommerfeld but more general than the Sommerfeld radiation condition for the validity of Sommerfeld's theory, has been verified for a consequent wave field from any infinite wavefront propagating forward.
Targets for gene therapy of vein grafts (1999)

Poor long-term patency and a lack of suitable systemic pharmacologic therapy for the prevention of vein graft failure have prompted the search for effective local gene therapy. Vein grafts are particularly well suited for gene transfer in the clinic because direct access to vein is available during surgical preparation for grafting. In this review, the available animal models are discussed and a new mouse model is highlighted. Recent advances in gene transfer technology are reviewed, including the use of adeno-associated virus and modified adenoviruses that can prolong in vivo transgene expression for months. Gene therapy is intended to reduce early thrombosis, reduce neointima formation, and prevent atherosclerosis in vein grafts. Promising antithrombotic targets include tissue plasminogen activator and thrombomodulin. Nitric oxide synthase, prostacyclin synthase, and tissue inhibitors of metalloproteinases have been used to reduce neointima formation, and vein graft atheroma remains a challenge for the future.
Abstract 4761: The iCD40. MyD88 combo-vector: A new platform for enhanced DC tumor immunotherapy (2010)

Abstract Introduction: Given the pre-eminent role of dendritic cells (DCs) as antigen-presenting cells, their exploitation as natural adjuvants in vaccination protocols for the treatment of various malignancies and infectious diseases is not surprising. Nevertheless, inadequate or unsustained activation has likely limited response rates in clinical trials. We previously reported a potent synthetic dimerizer drug-inducible CD40 (iCD40) receptor that permits temporally controlled DC-specific activation within the context of an immunological synapse (Hanks et al, Nat Med, 2005). We showed that when combined with Toll-like Receptor (TLR) adjuvants, iCD40-modified DCs (iCD40-DCs) have enhanced survival, co-stimulatory marker expression, migration, IL-12 production, antigen (Ag)-specific T cell stimulatory capacity and anti-tumor responses (Lapteva et al, Cancer Res, 2007). A phase I/II clinical trial based on iCD40-DCs to treat castration-resistant, metastatic prostate cancer began enrolling patients in August 2009. Procedures: To simplify this approach, we have developed a unified, inducible DC switch, called “iCD40. MyD88”, which combines signaling elements from costimulatory molecule, CD40, and TLR adapter, MyD88, fused to tandem FK506-binding binding proteins (FKBP12v36). Activation is initiated in vitro or in vivo by lipid-permeable dimerizing ligands (i.e. AP1903 or AP20187). Results: Both murine and human iCD40. MyD88-DCs secrete high (ng) levels of IL-12 and maturation markers in a ligand-dependent fashion without the need for exogenous adjuvants. iCD40. MyD88 activation is associated with synergistic activation of IKK&#945;/&#946; and p38. Moreover, tumor-bearing mice treated with antigen-pulsed, iCD40. MyD88-DCs show a potent anti-tumor immune response, consistent with expansion of antigen-specific CTLs in vivo. Bicistronic vectors combining iCD40. MyD88 along with tumor-associated antigens are underway. Conclusion: This “combo-switch” permits potent, targeted activation of antigen-pulsed DCs in vivo, leading to improved anti-tumor immunity with a high likelihood for reduced side effects. Production of a single vector that combines a potent DC switch with tumor antigen is the first requisite step leading to economically viable, “off-the-shelf”, vaccine therapies for cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4761.
Potent agonists of growth hormone-releasing hormone. II. (1992)

Analogs of the 29-amino acid sequence of growth hormone-releasing hormone (GH-RH) with agmatine (Agm) or Lys-NH2 in position 29 have been synthesized by the solid-phase method, purified, and tested in vitro. Except for one peptide, all analogs contained desaminotyrosine (Dat) in position 1. All contained Nle27 in order to avoid oxidation of Met27. Some peptides contained one or more additional L- or D-amino acid substitutions in positions 2, 12, 15, 21, 27 and/or 28. Analogs [Dat1, Ala15, Nle27, Asn28]GH-RH(1-28)Agm (II, [Asn28]-Mz-2-51); [Dat1, Ala15, D-Lys21, Nle27, Asn28]GH-RH(1-28)Agm (III, MZ-3-125); and [Dat1, D-Asn8, Ala15, D-Lys21, Nl27, Asn28]GH-RH(1-28)Agm(IV, MZ-3-129) were 5.7, 2.8, and 3.9 times more potent in vitro, respectively, than GH-RH(1-29)NH2. However, if we compare the potencies of peptides II and III (analogs of the bovine sequence) with those of the analogs of human GH-RH (XII and XIII) [Dat1, Ala15, Nle27]GH-RH(1-28)Agm; [Dat1, Ala15, D-Lys21, Nle27]GH-RH(1-28)Agm, respectively, the GH-releasing potency was decreased by 50% and 33%, respectively, by the incorporation of Asn28. Our studies indicate that Lys-NH2 at the C-terminus of GH-RH(1-29) and/or beta-Ala, GABA (gamma-aminobutyric acid), and Phe in position 15 are disadvantageous, but potent GH-RH analogs can result from the combination of agmatine in position 29 with other substitutions.
Lectin-induced differentiation of transformed neuroretinal cells in vitro (1992)

The orderly course of chick neuroretinal cell differentiation was disrupted in vitro by infection with a temperature-sensitive strain of the Rous sarcoma virus (LA29). The resulting cell culture LA29NR remained mitotically active at 42 degrees C, yet rapidly adopted a transformed phenotype upon activation of the pp60v-src oncogene product at 37 degrees C. As a further indication of metabolic state, LA29NR cells expressed the protooncogene product c-Fos, as shown by Western blot analysis. Highly proliferative LA29NR cells proved refractory to standard differentiation agents such as cAMP, and prostaglandin E1. In our novel approach, succinylated concanavalin A (SCA), a nontoxic derivative of the lectin concanavalin A, induced dramatic, reversible morphological changes in LA29NR cells, including neurite outgrowth and increased cell-to-cell adhesion. Fluoresceinated SCA appeared to localize to Golgi and lysosomal structures. Cellular response to SCA treatment included decreased growth rate, reversible decrease in the phosphorylation state of a 41-kDa phosphoprotein, and induction of neuron-specific enolase. The glial marker vimentin was also evident in these cultures. These data suggest that SCA is an effective differentiation agent for cells of neuroectodermal origin, permitting neuronal as well as glial phenotypic expression within these cell populations.
Receptor autoimmunity: diagnostic and therapeutic implications (2020)

Receptor autoimmunity is one of the ways in which autoimmune diseases appear in humans. Graves' disease, myasthenia gravis, idiopathic membranous nephropathy, and autoimmune acute encephalitis are the major autoimmune diseases belonging to this particular group. Receptor autoimmune disease are dependent on the presence of autoantibodies directed against cell-surface antigens, namely TSH receptor in thyrocytes, acetylcholine receptor in neuromuscular junction, phospholipase 2 receptor in podocytes, and NMDA receptor in cortical neurons. In this article we outline the distinctive features of receptor autoimmunity and the specific relationship between the autoimmunology laboratory and the presence/concentration of autoantibodies. Some immunological features distinguish receptor autoimmunity. Anti-receptor autoantibody pathologies are considered T cell-dependent, B-cell-mediated autoimmune disorders: the knowledge about the presence of circulating and/or localized autoantibodies to target organs and identification of autoantigens involved in the autoimmune reaction is of paramount importance. Due to the close correlation between the concentration of anti-receptor autoantibodies, the autoimmune target of some cell-surface receptors and the intensity of symptoms, the measurement of these immunoglobulins has become central to diagnose autoimmune diseases in all affected patients, not just in clinically dubious cases. The measurement of autoantibodies is also relevant for differential diagnosis of autoimmune and non-autoimmune forms with similar symptoms. From the methodological point of view, quantitative immunoassay methods of measurement should be preferred over semi-quantitative ones, for the capacity of the first class of methods to define precisely the reference ranges and decision levels overcoming the measurement uncertainty of semi-quantitative methods.
Satan and savior: Mass communication in progressive thought (1989)

This essay probes the contradictory philosophical reception of mass communication in the social thought of progressives such as Cooley, Dewey, Park, and Royce. Mass communication served as a focus for larger anxieties about social order, social evolution, the future of American democracy, and the integrity of the public sphere. The theoretical grapplings of these thinkers with the symbolic mediation of society, however inadequate they are, show us that the relation between society and its self‐representations is a problem for modern society generally, not only for the putatively “postmodern”; climate of the late twentieth century.
Phosphoric Acid and Phosphates (2008)

Abstract The article contains sections titled: 1. Monophosphoric Acid 1.1. Properties 1.2. Production 1.2.1. Thermal Processes 1.2.2. Wet Processes 1.2.3. Concentration of Wet Phosphoric Acid 1.2.4. Purification of Wet Phosphoric Acid 1.3. Uses and Economic Aspects 1.4. Environmental Aspects 2. Condensed Phosphoric Acids 3. Phosphates 3.1. Sodium Monophosphates 3.2. Condensed Sodium Phosphates 3.2.1. Properties 3.2.2. Metal Complexing by Phosphates 3.2.2.1. Introduction 3.2.2.2. Analytical Methods 3.2.2.3. Complexing by Individual Phosphates 3.2.2.4. Other Concepts Besides the Stability Constant 3.2.3. Sodium Diphosphates 3.2.4. Pentasodium Triphosphate 3.2.5. Higher Condensed Sodium Polyphosphates 3.2.6. Sodium Metaphosphates 3.2.7. Uses of Condensed Sodium Phosphates 3.3. Other Phosphates 3.3.1. Potassium Phosphates 3.3.2. Ammonium Phosphates 3.3.3. Magnesium Phosphates 3.3.4. Calcium Phosphates 3.3.5. Boron Phosphate 3.3.6. Aluminum Phosphates 3.4. Economic Aspects 4. Toxicology
Effect of delay mismatch on a feedforward amplifier (1994)

The suitability of feedforward amplifiers for satellite systems has thus far been limited by their poor overall DC to RF conversion efficiency. This is a consequence of the additional power amplifiers required to provide the distortion cancellation. In narrowband systems, other techniques have been used in preference to feedforward because they offer the advantages of improved efficiency, and reduced complexity. If, however, the power efficiency could be improved, and the size reduced, the benefits of feedforward could be more readily exploited. These improvements can be achieved by a reduction of the time delay elements. The paper presents an analysis and practical results of the implementation of shortened delay elements for both satellite (broadband) and narrowband applications.