gebhart/patrepeval huggingface dataset:
Chemiluminescence of lithium phosphides (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemiluminescence of lithium phosphidesRichard A. Strecker, Jonathan L. Snead, and Gilbert P. SollottCite this: J. Am. Chem. Soc. 1973, 95, 1, 210–214Publication Date (Print):January 1, 1973Publication History Published online1 May 2002Published inissue 1 January 1973https://pubs.acs.org/doi/10.1021/ja00782a037https://doi.org/10.1021/ja00782a037research-articleACS PublicationsRequest reuse permissionsArticle Views661Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design and implementation of a configurable hardware profiler supporting path profiling and sampling (2009)

Profiling plays an important role in performance optimization, such as instruction set optimization, dynamic binary translation and so on. Unfortunately, profilers nowadays often lack in efficiency on two key attributes: accuracy and profiling time. In this paper, we introduce a configurable hardware path profiler deriving from previous work, based on the idea of sampling and path profiling. The profiler consists of three modules respectively for identifying branches, detecting paths and storing information. It can work with different processors loosely. It utilizes dynamic path profiling technique on instruction level to accurately obtain sensitive hot information of executing programs while supports multiple sampling policies to reduce profiling overheads. Through configuration, the profiler can perform different profiling policies and profile target programs continuously or discretely. Empirical experiments show that the profiler can reduce hardware timing to 6.4% and keep the accuracy up to 90%.
Performance enhancement of partially- and fufly-depleted strained-SOI MOSFETs and characterization of strained-Si device parameters (2005)

This paper demonstrates the successful fabrication of strained-SOI MOSFETs using SiGe on insulator (SGOI) substrates. 200mm SGOI wafer with Ge content of 30% is fabricated by Ge condensation technique. The performance enhancement over 14% is obtained in gate length of 70 nm. Furthermore, fully-depleted strained-SOI MOSFETs with back gate is demonstrated. Thin strained-Si layer can suppress the abnormal off leakage current due to the enhancement impurity diffusion.
Differences in Fracture Characteristics and Related Production: Mesaverde Formation, Northwestern Colorado (1989)

Summary Reservoirs in the Mesaverde formation in the Piceance Creek basin, northwestern Colorado, consist of naturally fractured, low-permeability sandstones. Permeability along the natural fractures is the primary mechanism of gas production. However, the characteristics of the natural fractures change within the formation at boundaries roughly coincident with changes in depositional environment, as seen in 4,200 ft [1280 m] of core from the U.S. DOE's Multiwell Experiment (MWX) wells. Depositional environment controlled the characteristics of the matrix rock and reservoir heterogeneity as well as the fracture permeability system. Therefore, natural gas production rates from the different zones in the formation can be correlated with the natural fracture characteristics from that zone. The fracture systems consist of unidirectional regional fractures that provide highly anisotropic reservoir permeability trends. Locally, secondary fractures were superimposed on the regional system, and higher production rates resulted. Production rates are low elsewhere, and little well-to-well communication across the fracture trend occurs. Moreover, stimulations of these reservoirs have often been unsuccessful because the hydraulic fractures propagate parallel to the natural fractures.
High level secretion of wild-type and mutant forms of human proapoA-I using baculovirus-mediated Sf-9 cell expression (1996)

To facilitate the investigation of apoA-I structure:function relationships as they relate to LCAT activation and lipid binding, we have developed an apoA-I baculoviral expression and purification system that yields milligram quantities of wild-type or mutant proapoA-I. Baculovirus-infected Sf-9 cells, grown in suspension, were found to secrete high levels of human wild-type (40-50 mg/l) or mutant apoA-I protein (1-38 mg/l), which was determined to be > 95% pure following a two-step purification procedure. In the case of wild-type apoA-I, ELISA showed that approximately 13-18% of the total protein secreted into the culture medium was apoA-I. To isolate pure protein from culture medium, 72 h post-infection medium was subjected to preparative reverse phase high performance liquid chromatography (HPLC), followed by DEAE ion-exchange chromatography. Purity and molecular size determination of wild-type proapoA-I protein was verified by SDS polyacrylamide gel electrophoresis, electrospray mass spectrometry, and N-terminal sequencing. In addition, recombinant discoidal apoA-I:phospholipid complexes prepared from wild-type or plasma apoA-I showed similar particle size and LCAT activation properties. To fully characterize the utility of this expression system, the expression levels of various mutant apoA-I proteins were compared to wild-type. Despite a lower production level seen with selected apoA-I mutants, milligram quantities of these purified mutant proteins were also obtained. In summary, we show that baculovirus-derived wild-type proapoA-I shows properties similar to plasma apoA-I relative to recombinant HDL formation, LCAT reactivity, and alpha-helical content. In addition, we show that a variety of mutant forms of human proapoA-I can be expressed and purified in abundant quantity from baculoviral-infected Sf-9 cells.
On the Mechanism of Thrombin-induced Angiogenesis (1999)

Many of the cellular actions of thrombin may contribute to the angiogenesis-promoting effect of thrombin reported previously. In this study, we investigated the interaction between thrombin and vascular endothelial growth factor (VEGF), the specific endothelial cell mitogen and key angiogenic factor. Exposure of human umbilical vein endothelial cells to thrombin sensitizes these cells to the mitogenic activity of VEGF. This thrombin-mediated effect is specific, dose-dependent and requires the activated thrombin receptor. Quantitative reverse transcription- polymerase chain reaction analysis reveals a time- and dose-dependent up-regulation of mRNA for VEGF receptors (KDR and flt-1). Optimal thrombin concentration for maximal expression of mRNA for KDR is 1.5 IU/ml (170% over controls) and appears 8-12 h after thrombin stimulation. Nuclear run-on experiments demonstrate that the up-regulation of KDR mRNA by thrombin occurred at the transcriptional level. In addition, functional protein of KDR receptor is increased to about 200% over control after 12 h of thrombin treatment. The up-regulation of KDR and flt-1 mRNA is also mimicked by the thrombin receptor activating peptide. These findings could explain at least in part the potent angiogenic action of thrombin.
Sex Hormone–Binding Globulin and the Free Androgen Index Are Related to Cardiovascular Risk Factors in Multiethnic Premenopausal and Perimenopausal Women Enrolled in the Study of Women Across the Nation (SWAN) (2005)

Low SHBG and high FAI are strongly associated with CV risk factors in racially diverse women, and thus, androgens likely play a role in the CV risk profile of perimenopausal women.
A defective cell surface collagen-binding protein in dermatosparactic sheep fibroblasts. (1988)

Fibroblasts from dermatosparactic sheep fail to contract collagen gels and show a reduced attachment to collagenous substrates. By comparing collagen-binding membrane proteins of normal (+/+), homozygote (-/-), and heterozygote (+/-) fibroblasts, we present evidence that the interaction of normal fibroblasts with native type I collagen involves a protein of apparent Mr = 34,000 which is absent from dermatosparactic fibroblasts and seems to be related to anchorin CII. This conclusion was reached from the following experiments: (a) On a blot of membrane proteins from normal fibroblasts radioactively labeled type I collagen bound predominantly to a protein band of 34 kD; dermatosparactic membranes revealed only a small amount of binding to a component with a molecular mass of 47 kD. (b) After separation of normal fibroblast membrane proteins on type I collagen-Sepharose, a collagen-binding component of 34 kD was found which was absent from the corresponding fraction of dermatosparactic membranes. (c) Antibodies to anchorin CII stained the surface of normal (+/+), but not of dermatosparactic (-/-) fibroblasts and labeled a 34-kD component after immunoblotting of normal fibroblast membrane proteins. (d) After metabolic labeling of fibroblasts with [35S]methionine and immunoprecipitation with anti-anchorin CII, 40- and 34-kD components were precipitated from extracts of normal fibroblasts, while the latter component was absent from affected cells. Similar differences were found after immunoblotting of membranes from whole normal or affected skin. These data indicate that dermatosparaxis of sheep involves a molecular defect of a collagen-binding protein. Therefore this disease represents a model to study the complex interaction of cells with the extracellular matrix on a molecular level.
Optically Pumped Intensive Light Amplification from a Blue Oligomer (2019)

We demonstrated the time-resolved dynamics of laser action from the conductive oligomer (CO) 1,4-Bis(9-ethyl-3-carbazo-vinylene)-9,9-dihexyl-fluorene (BECV-DHF). Absorption and fluorescence spectra were studied for BECV-DHF in different solvents under a wide range of concentrations. The Fourier-transform infrared spectroscopy (FTIR) spectrum was measured using simulation and experiments. The Ultraviolet-Visible (UV-VIS) spectra of the BECV-DHF were simulated in two different solutions. This CO formed a dimer and had two vibration bands in nonpolar solvents, partially dissolved in polar protic solvents, and created an H-type aggregate in polar aprotic solvents. BECV-DHF produced amplified spontaneous emission (ASE) at 464 nm in many solvents. The high efficiency of ASE is due to the waveguiding and self-assembly nature of the oligomer, which is very rare for optically pumped systems. However, BECV-DHF did not produce ASE in polar protic solvents. BECV-DHF produced ASE in both longitudinal and transverse pumping, and the full-width half maximum (FWHM) was 4 nm and 8 nm respectively for different solvents, such as toluene and acetone. The CO had a very low threshold pump energy (~0.5 mJ). The ASE efficiency was approximately 20%. The time-resolved spectroscopy (TRS) studies showed a temporal Gaussian-shaped ASE output from this CO. BECV-DHF shows remarkably high stability compare to the conjugated polymer (CP) PFO-co-pX.
FPGA ACCELERATION WINDOW JOINS OVER MULTIPLE DATA STREAMS (2005)

Recently there has been a growing interest in window joins for scenarios in which data streams arrive at very high rates and a DSMS is registered with many simultaneous queries. Most of the algorithms proposed in the literature are implemented by software. In contrast, we present a novel algorithm named M3Join which can be implemented by software or hardware. M3Join is based on a join architecture which contains a join-routing-table and several half-join architectures. The join architecture is initialized or updated according to the simultaneous queries. Each tuple in the data streams extended with a route tag searches the join-routing-table and switches into the proper half-join architecture to perform join operations or return to end users. The generated join tuples whose route tags have been updated iterate the above search and join procedures until there is no join tuples produced. The algorithm needs only one scan over the data streams since different join queries share the intermediate results. The FPGA implementation of M3Join is presented in detail. The experimental results show that the algorithm is effective and hardware can accelerate join processing vastly.
Estimating sampling completeness of lidar datasets using voxel-based geometry (2014)

Advances in LIDAR technology have made sub-meter resolutions from airborne instruments possible, enabling quick capture of fine 3D details over large areas. During collection, occluding objects may prevent a laser pulse from reaching regions where overlapping geometry is present, such as under tree canopies. This is particularly true given the near-nadir angles typically used by airborne LIDAR, since the limited number of unique angles does not ensure that all surfaces can be sensed. These missed surface detections decrease the overall quality of a dataset, but are not normally quantified due to a lack of ground-truth. Using information that is normally discarded about the LIDAR instrument position, we show how these unsampled regions can be identified by tracing the path of each laser pulse. A voxel representation provides the framework for computing the necessary statistics, and also allows for correct representations of overlapping geometry in complex environments. Based on this novel unsampled information we show how the fraction of total surfaces sensed and not sensed by the LIDAR can be estimated, giving a measurement of how completely all surfaces are sampled. Results are demonstrated for a real-world dataset, including the effects of voxel resolution and data density on the sampling completeness metric.
Steroids. III. Alumina-Induced Reactions of Steroidal Oxime Acetates (1973)

An alumina-induced reaction of 6-acetoximino-3β-acetoxycholestan-5α-ol nitrite (I) is examined and affords several kinds of compounds. Among them II, III and IV are belong to the same type of compound. From the spectral data and their reactions, the structures containing 5α, 6α-epoxy and 6β, 7β-isonitrosoimino groups are tentatively assumed for them. V and VI are identified to be another type containing 5α-acetoxy and 6-oxo groups. The formation pathways of both types of compounds are deduced by comparison with the reaction products of the relative compounds.
Detecting carbonate‐karst reservoirs using the directional amplitude gradient difference technique (2011)

Karst‐controlled Ordovician carbonate formations are the main oil‐ and gas‐bearing reservoirs in the Tarim Basin, China. Unlike clastic reservoirs and carbonate reservoirs in other areas, the carbonate‐karst reservoir in the Tarim Basin has its distinct characteristics that make its detection difficult because no pronounced effect can be recovered using conventional techniques and methods. In this paper, a new method, directional‐amplitude‐gradient‐difference, using the least‐squares‐fitting (LSF) algorithm, is presented and used to detect carbonate‐karst reservoirs. The method estimates the rate of change of the seismic amplitude, also known as the gradient, horizontally and vertically and calculates the difference between these directions. Compared with other gradient‐estimation methods, the proposed directional‐amplitude‐gradient‐difference has clear advantages. A field‐data example shows that the method can improve accuracy and efficiency in the detection of carbonate‐karst reservoirs.
Multiwavelength Bragg gratings and their application to optical MUX/DEMUX devices (2003)

A concept of synergetic multiwavelength Bragg gratings as a platform for planar integrated optical devices is proposed and used to make a planar multiplexer/demultiplexer for wavelength-division multiplexing. In first experiments, the devices with 4-16 channels were made on SiON planars with single-layer lithography. Almost flat-top transfer function and 28-dB isolation were achieved for a four-channel device. The gratings with custom designed bandgaps could be also used to connect multiple optical devices in lightwave integrated circuits.
Efficient Synthesis of 2-Vinyl-γ-butyrolactones and 2-Vinyl-γ-butyrolactams by Palladium-Catalyzed Decarboxylative Carbonylation (1992)

Abstract 4-Vinyl-1,3-dioxan-2-ones (cyclic carbonates) undergo decarboxylation-carbonylation by the catalysis of Pd(0) species under CO (in most cases, 1 atm) to provide 2-vinyl-γ-butyrolactones in good yields. The course of the reaction of 6-vinyltetrahydro-2H-1,3-oxazin-2-ones (cyclic carbamates) depends on the substituent on the nitrogen atom. When it is H or Ts (and COPh), 2-vinyl-γ-butyrolactams or 6-amino-3-hexenoic acid esters are obtained. Cyclic N-benzylcarbamates are unreactive. trans-2,3-Disubstituted lactones and lactams arise stereoselectively from carbonates and carbamates, irrespective of their stereochemistry, respectively.
Epidermal growth factor-like domain 7 promotes migration and invasion of human trophoblast cells through activation of MAPK, PI3K and NOTCH signaling pathways (2015)

Epidermal growth factor-like domain 7 (Egfl7) is a gene that encodes a partially secreted protein and whose expression is largely restricted to the endothelia. We recently reported that EGFL7 is also expressed by trophoblast cells in mouse and human placentas. Here, we investigated the molecular pathways that are regulated by EGFL7 in trophoblast cells. Stable EGFL7 overexpression in a Jeg3 human choriocarcinoma cell line resulted in significantly increased cell migration and invasiveness, while cell proliferation was unaffected. Analysis of mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways showed that EGFL7 promotes Jeg3 cell motility by activating both pathways. We show that EGFL7 activates the epidermal growth factor receptor (EGFR) in Jeg3 cells, resulting in downstream activation of extracellular regulated kinases (ERKs). In addition, we provide evidence that EGFL7-triggered migration of Jeg3 cells involves activation of NOTCH signaling. EGFL7 and NOTCH1 are co-expressed in Jeg3 cells, and blocking of NOTCH activation abrogates enhanced migration of Jeg3 cells overexpressing EGFL7. We also demonstrate that signaling through EGFR and NOTCH converged to mediate EGFL7 effects. Reduction of endogenous EGFL7 expression in Jeg3 cells significantly decreased cell migration. We further confirmed that EGFL7 stimulates cell migration by using primary human first trimester trophoblast (PTB) cells overexpressing EGFL7. In conclusion, our data suggest that in trophoblast cells, EGFL7 regulates cell migration and invasion by activating multiple signaling pathways. Our results provide a possible explanation for the correlation between reduced expression of EGFL7 and inadequate trophoblast invasion observed in placentopathies.
Microstructure and Properties of Spark Plasma Sintered Aluminum Containing 1 wt.% SiC Nanoparticles (2015)

The low hardness and strength of aluminum, which limits its use in many industrial applications, could be increased through the addition of nanoparticles. However, the appropriate processing method and parameters should be carefully selected in order to achieve the desired improvement in properties. In this work, aluminum was reinforced with low weight fraction (1 wt.%) of SiC nanoparticles and consolidated through spark plasma sintering. The effect of processing parameters on the densification, microstructure, and properties of the processed material was investigated. Field Emission Scanning Electron Microscope (FE-SEM) equipped with Energy Dispersive X-ray Spectroscopy (EDS) facility was used to characterize the microstructure and analyze the reinforcement’s distribution in sintered samples. Phases present were characterized through X-ray diffraction (XRD). A densimeter and a digital microhardness tester were used to measure the density and hardness, respectively. Compressive tests were performed using universal testing machine. A fully dense Al-1 wt.% SiC sample was obtained. Analysis of density and hardness values showed that the influence of applied pressure was more pronounced than heating rate while the influence of sintering temperature was more significant than sintering time. Within the range of parameters used, the highest values of the characterized properties were obtained at a sintering temperature of 600 °C, sintering time of 10 min, pressure of 50 MPa, and heating rate of 200 °C/min.
Driver assistance: an integration of vehicle monitoring and control (2004)

About 1.17 million people die in road crashes around the world each year. It is estimated that up to 30% of these fatalities are caused by fatigue and inattention. There are systems able to detect what is happening outside of the car, e.g., lane tracking, obstacle detection, pedestrian detection etc. Further on, there are also means for monitoring the actions of the driver. A natural step is to fuse the available data from within and outside of the car, and suggest a suitable response. This paper discusses driver assistance systems, lists a set of necessary core competencies of such a system and in particular presents a system for force-feedback in the steering wheel when crossing lanes. The presented system utilises a robust lane tracker which is experimentally evaluated for the purpose of driver assistance. In addition, preliminary results from simultaneous driver monitoring and lane tracking are presented that indicates a good correlation between the two, i.e. the driver's gaze direction and the structure of the road. These data can in turn be used for more advanced driver assistance systems in the future.
TGF-β Concentration Specifies Differential Signaling Profiles of Growth Arrest/Differentiation and Apoptosis in Podocytes (2005)

Podocyte depletion occurs in most progressive glomerular diseases and is thought to result from podocyte loss while the remaining podocytes are unable to proliferate. The underlying mechanisms for podocyte growth arrest/differentiation and depletion remain poorly understood but may involve TGF-beta, which is typically upregulated in injured glomeruli. The TGF-beta are multifunctional cytokines that regulate growth, differentiation, and apoptosis in most cells. Determinants of functional specificity of TGF-beta signaling in cell-cycle control and apoptosis remain poorly understood. Using a unique system of conditionally immortalized podocytes, it is demonstrated that autocrine TGF-beta2 induces G0/G1 arrest and differentiation under nonpermissive culture through Smad3-dependent induction of the cyclin-dependent kinase inhibitor p15(Ink4b) (Cdkn2b). When exposed to recombinant TGF-beta1 (or TGF-beta2), nonpermissive culture podocytes switch to G2/M arrest and apoptosis, selectively at advanced TGF-beta concentrations and specifically in association with suppression of Cdkn2b and activation of proapoptotic p38 mitogen-activated protein kinase. Thus, distinct signaling profiles activated in a concentration-dependent manner by TGF-beta were identified. Autocrine TGF-beta2/Smad3/Cdkn2b signaling in podocytes specifies G0/G1 arrest associated with podocyte differentiation, whereas increasing TGF-beta concentrations beyond a critical threshold induces G2/M block and apoptosis associated with selective p38 mitogen-activated protein kinase activation and with suppression of Cdkn2b. In summary, the results suggest a new functional requirement of TGF-beta2 in growth arrest and differentiation of murine podocytes in vitro and demonstrate that a critical TGF-beta concentration threshold may specify a molecular switch to proapoptotic signaling profiles and apoptosis.