gebhart/patrepeval huggingface dataset:
Transplantable rat glucagonomas cause acute onset of severe anorexia and adipsia despite highly elevated NPY mRNA levels in the hypothalamic arcuate nucleus. (1998)

We have isolated a stable, transplantable, and small glucagonoma (MSL-G-AN) associated with abrupt onset of severe anorexia occurring 2-3 wk after subcutaneous transplantation. Before onset of anorexia, food consumption is comparable to untreated controls. Anorexia is followed by adipsia and weight loss, and progresses rapidly in severity, eventually resulting in reduction of food and water intake of 100 and 80%, respectively. During the anorectic phase, the rats eventually become hypoglycemic and hypothermic. The tumor-associated anorexia shows no sex difference, and is not affected by bilateral abdominal vagotomy, indicating a direct central effect. The adipose satiety factor leptin, known to suppress food intake by reducing hypothalamic neuropeptide Y (NPY) levels, was not found to be expressed by the tumor, and circulating leptin levels were reduced twofold in the anorectic phase. A highly significant increase in hypothalamic (arcuate nucleus) NPY mRNA levels was found in anorectic rats compared with control animals. Since elevated hypothalamic NPY is among the most potent stimulators of feeding and a characteristic of most animal models of hyperphagia, we conclude that the MSL-G-AN glucagonoma releases circulating factor(s) that overrides the hypothalamic NPY-ergic system, thereby eliminating the orexigenic effect of NPY. We hypothesize a possible central role of proglucagon-derived peptides in the observed anorexia.
Antifungal susceptibility of <i>Candida albicans</i> in biofilms (2011)

Candida albicans are the most common fungi associated with biofilm-related infections. Biofilms are defined as microbial communities encased in a matrix of extracellular polymeric substances. The most important feature of biofilm growth is the high resistance to antimicrobial agents that can be up to 1000-fold greater than that of planktonic cells. This review discusses the factors affecting antifungal resistance as well as activity of mono- and combination therapy of different antifungal classes and antifungal activity in vitro and in vivo against C. albicans biofilms.
Silicon-Based Non Aqueous Anolyte for Li Redox-Flow Batteries (2013)

International audience
Energy band alignment in GaAs:(Al,Ga)As heterostructures: The dependence on alloy composition (1986)

The band alignment in GaAs:(Al,Ga)As heterostructures has been investigated over the full range of alloy composition. The valence-band discontinuity ΔEv is determined by measuring the activation energy for thermionic emission of holes from p-GaAs over an undoped, square (Al,Ga)As barrier. The use of p-type structures to measure ΔEv circumvents a number of complications involved in the measurement of ΔEc. The parameters required for analysis are determined by different measurements on the same structures and the analysis is performed so that the activation energy, extrapolated to zero bias, yields ΔEv directly. It is found that ΔEv is a linear function of the aluminum mole fraction xAl: ΔEv ≂0.55xAl (eV) (0≤xAl≤1). The validity of these data is supported by measurements of ΔEc in the direct band-gap regime, where complementary values of ΔEv and ΔEc add up to the expected band-gap difference. This relationship provides a simple description of the full band alignment in this heterosystem and should prove valuable as a test of the various heterojunction lineup theories. Moreover, these measurements have a number of important consequences, particularly from the viewpoint of heterojunction devices.
Design And Performance Analysis Of A Supersonic Diffuser For Plasma Wing Tunnel (2011)

Plasma Wind Tunnels (PWT) are extensively used for screening and qualification of re-entry Thermel Protection System (TPS) materials. Proper design of a supersonic diffuser for plasma wind tunnel is of importance for achieving good pressurerecovery (thereby reducing vacuum pumping requirement & run time costs) and isolating downstream stream fluctuations from propagating costs) and isolating downstream stream fluctuationnts the details of a rapid design methodology successfully employed for designing supersonic diffuser for high power (several megawatts)plasma wind tunnels and numerical performance analysis of a diffuser configuration designed for one megawatt power rated plasma wind tunnel(enthalpy ~ 30 MJ/kg) using FLUENT 6.3® solver for different diffuser operating sub-atmospheric back-pressures.
Volumetric description of dip solder joints from range data (2002)

Dip solder joints exhibit a variety of complex shapes, making inspection by traditional representation methods difficult. Traditional approaches use various features of 2D images to represent joint shape; however, correct 3-D representation is essential when analyzing joint shape for visual inspection. We present a method of using generalized cylinders (GCs) to obtain a 3-D representation of a solder joint from the joint's range image. This method is based on symmetry detection. B-spline contour representation allows analytical detection of a symmetry axis that is used as a basis for the GC axis. In addition, we present a B-spline fitting method that uses an initial line fitting procedure. The contour of the cross section is expressed as an ellipse using an ellipse-specified conic fitting method. Correct representations for over 53 test sample range images were obtained.
Pathways of Proliferation and Antiapoptosis Driven in Breast Cancer Stem Cells by Stem Cell Protein Piwil2 (2010)

Cancer stem cell studies may improve understanding of tumor pathophysiology and identify more effective strategies for cancer treatment. In a variety of organisms, Piwil2 has been implicated in multiple roles including stem cell self-renewal, RNA silencing, and translational control. In this study, we documented specific expression of the stem cell protein Piwil2 in breast cancer with predominant expression in breast cancer stem cells. In patients who were evaluated, we determined that 90% of invasive carcinomas and 81% of carcinomas in situ exhibited highest expression of Piwil2. In breast cancer cells, Piwil2 silencing suppressed the expression of signal transducer and activator of transcription 3, a pivotal regulator of Bcl-X(L) and cyclin D1, whose downregulation paralleled a reduction in cell proliferation and survival. Our findings define Piwil2 and its effector signaling pathways as key factors in the proliferation and survival of breast cancer stem cells.
Cell-surface plasminogen activation causes a retraction of in vitro cultured human umbilical vein endothelial cell monolayer (1994)

Vascular endothelium forms a dynamic interface between blood and underlying tissues. Endothelial monolayer integrity is required for controlled vascular permeability and to preclude exposure of subendothelial cell matrix to circulating cells. Recent studies have established that cultured human umbilical vein endothelial cells (ECs) express receptors for plasminogen (plg) and urokinase-like plasminogen activator (uPA). In the present study, we provide evidence that in EC, uPA receptor is present in focal contacts and at cell-cell contact sites. In these cells, addition of plg and uPA to confluent EC generates a retraction of the monolayer that is evidenced by loss of cell-cell contacts and increase in monolayer permeability. The phenomenon is reversible even after 6 hours of plg-uPA treatment. Inhibition of plg-uPA effect is obtained with plasmin inhibitors, as well as reagents that block binding of uPA or plg to the cell surface. The retractive effect of plg-uPA is concomitant to surface activation of plasminogen and to the loss of cell-cell activation of plg can induce EC retraction, possibly by causing proteolysis at specific cell-cell contacts and cell-matrix sites. This process may be important in mediating the passage of metastatic tumor cells through an intact EC monolayer as well as in regulating contacts between circulating cells and endothelium.
TGF-beta signaling in atherosclerosis and restenosis (2009)

Current theories suggest that atherosclerotic and restenotic lesions result from imbalances between systems that are proinflammatory/fibroproliferative versus the endogenous inhibitory systems that normally limit inflammation and vascular wound repair. Abnormalities in one of the major regulatory pathways, the transforming growth factor-beta (TGF-beta) system, has been characterized in both animal models and in human lesions and lesion-derived cells. TGF-beta signaling is capable of regulating many of the key aspects of atherosclerosis and restenosis: inflammation, chemotaxis, fibrosis, proliferation, and apoptosis. There are significant decreases in TGF-beta activity in patients with atherosclerosis, and equally important changes in the way cells respond to TGF-beta during atherogenesis. Evidence from multiple sources indicates that experimental modulation of TGF-beta activity, or TGF-beta responses, changes the course of atherosclerosis and intimal hyperplasia. Cells derived from human lesions produce adequate TGF-beta levels, but are resistant to the antiproliferative and apoptotic effects of TGF-beta. An evolving theory describes TGF-beta as a major orchestrator of the vascular repair process, with observable defects in its production, activation, and cellular responses during the atherosclerotic and restenotic processes.
Copper nanoparticles in zeolite Y (1999)

CuCl has been dispersed in the supercages of a Y-type zeolite by heating a mechanical salt/host mixture in vacuo. The occluded salt was subsequently reduced to copper metal in a hydrogen atmosphere. Virtually complete reduction of the salt is achieved at 460 °C. Under the same conditions, extraframework copper(II) ions, exchanged into zeolite NaY, are only partly reduced. The copper forms nanoaggregates of narrow size distribution inside the zeolite pore system; the average particle diameter is 5 nm. Our data suggest that these nanoparticles consist of several interconnected copper assemblies of supercage (diameter 1.2 nm) size. A small fraction of the salt remains at the outer surface of the zeolite crystallites in the inclusion step, and there produces larger copper metal particles upon reduction with H 2 .
SLAC: 3D localization of human based on kinetic human movement capture (2011)

This article introduces a method called SLAC (Simultaneous Localization And Capture) to track the spatial location of a human using wearable inertia sensors without additional external assistive global sensing device (e.g., camera, ultrasound, IR, etc.) The method uses multiple wearable inertia sensors to determine the orientation of the body segments and lower limb joint motions. At the same time, based on human kinematics and locomotion phase detection, the spatial position and trajectory of a reference point on the body can be determined. Preliminary experimental study has shown that the position error of SLAC can be controlled stairs within less than 2% error of the total distance travelled for a person to walk around a rectangle on the floor and climb up and down stairs. A benchmark study on the accuracy of SLAC was carried out using the camera-based Motion Analysis® system. The localization data obtained from SLAC tally well with that from the commercial system. The positioning accuracy obtained from SLAC is at least an order of magnitude better than that of GPS. Since the sensors can be worn on the human at any time and any place, this method has no restriction to indoor and outdoor applications and is complimentary to GPS applications.
Proteomic Analysis of MCF-7 Cell Lines Expressing the Zinc-Finger or the Proline-Rich Domain of Retinoblastoma-Interacting-Zinc-Finger Protein (2006)

To identify a growth-promoting activity related to retinoblastoma-interacting-zinc-finger (RIZ) protein, differential protein expression of MCF-7 cell lines expressing the zinc-finger or the proline-rich domain of RIZ protein was analyzed by a robust bottom-up mass-spectrometry proteomic approach. Spots corresponding to qualitative and quantitative differences in protein expression have been selected and identified. Some of these proteins have been previously reported as being associated with different types of carcinomas or involved in cell proliferation and differentiation. Knowledge of specific differentially expressed proteins by MCF-7-derived cell lines expressing RIZ different domains will provide the basis for identifying a growth-promoting activity related to RIZ gene products.
Identification of target areas for deep brain stimulation in human basal ganglia substructures based on median nerve sensory evoked potential criteria (2003)

Based on SEP criteria, the VIM target but not the STN region can be identified by typical SEP configuration changes, when penetrating the target zone. The approach is independent of the patient's cooperation and vigilance and therefore feasible in general anaesthesia. It provides an easy, reliable, and robust tool for the final assessment of electrode positions at the last instance during electrode implantation when eventual electrode revisions can easily be performed.
Identification of the differentiation-associated p93 tyrosine protein kinase of HL-60 leukemia cells as the product of the human c-fes locus and its expression in myelomonocytic cells. (1988)

A differentiation-associated 93-kDa tyrosine kinase (p93) was purified previously from the human promyelocytic leukemia cell line HL-60. The present study conclusively identifies p93 as the c-fes proto-oncogene product and shows that expression of p93c-fes and its associated tyrosine kinase activity are marked in mature granulocytes, monocytes, and human myeloid leukemia cell lines. Antisera to peptides obtained by expression of c-fes cDNA fragments in Escherichia coli reacted strongly with p93 purified from HL-60 cells. Western blots using one of these antisera demonstrated high levels of p93c-fes protein in normal human granulocytes and monocytes, as well as the cell lines KG-1, THP-1, HEL, and U-937, all of which can be induced to differentiate along the myelomonocytic pathway. Conversely, in cell lines resistant to myeloid differentiation, p93c-fes expression was either very low or absent. Expression of immunoreactive p93c-fes in these cell lines showed a strong positive correlation with p93c-fes tyrosine kinase activity, which was measured in cell extracts using a nondenaturing gel assay. Finally, the expression of p93c-fes, its tyrosine kinase activity, and the binding of 125I-granulocyte-macrophage colony-stimulating factor (GM-CSF) were all coordinately increased in HL-60 cells treated with the granulocytic differentiation inducer dimethyl sulfoxide, while all three parameters were low in untreated or differentiation-resistant HL-60 cells. These results suggest that expression of p93c-fes tyrosine kinase activity may be an essential component of myeloid differentiation and responsiveness to granulocyte-macrophage colony-stimulating factor.
Somatostatin-Receptor Imaging for the Detection of Tumors (1990)

The neuropeptide somatostatin was discovered in Guillemin's laboratory at the Salk Institute 18 years ago.1 From a relatively humble beginning as a hypothalamic growth hormone inhibitor, it has emerged as a major regulatory peptide with an extraordinary range of biologic actions.2 Cells containing somatostatin are typically neurons or endocrine-like cells, found in their highest density in the brain, among peripheral neurons, in the endocrine pancreas and in the gastrointestinal tract, and in small numbers in the thyroid, adrenals, submandibular gland, urinary tract, and placenta. These cells produce various mixtures of the two biologically active somatostatins — somatostatin-14, the form originally . . .
Continuous Palatography (1964)

No AccessJournal of Speech and Hearing DisordersThe Forum1 Nov 1964Continuous Palatography William L. Kydd, and Donald A. Belt William L. Kydd University of Washington Google Scholar and Donald A. Belt University of Washington Google Scholar https://doi.org/10.1044/jshd.2904.489 SectionsAboutPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In Additional Resources FiguresReferencesRelatedDetailsCited by Folia Phoniatrica et Logopaedica72:6 (419-428)Influence of the Covering Area of Major Connectors of Mandibular Dentures on the Accuracy of Speech Production: A Pilot StudyJunichiro Wada, Masayuki Hideshima, Keiichiro Uchikura, Yuka Shichiri, Shusuke Inukai, Hiroshi Matsuura and Noriyuki Wakabayashi Ratree Wayland (2020) Phonetics (2018) Experimental Tools in Articulatory Phonetics Phonetics10.1017/9781108289849.012 Folia Phoniatrica et Logopaedica70:3-4 (138-148)Influence of Oral Morphology on Speech Production in Subjects Wearing Maxillary Removable Partial Dentures with Major ConnectorsJunichiro Wada, Masayuki Hideshima, Shusuke Inukai, Azusa Katsuki, Hiroshi Matsuura and Noriyuki Wakabayashi Journal of Prosthodontic Research55:4 (234-242)1 Oct 2011Influence of the major connector in a maxillary denture on phonetic functionJunichiro Wada, Masayuki Hideshima, Shusuke Inukai, Tomohiro Ando, Yoshimasa Igarashi and Hiroshi Matsuura Second Language Research26:1 (13-41)1 Jan 2010Measuring language-specific phonetic settingsIneke Mennen, James M. Scobbie, Esther de Leeuw, Sonja Schaeffler and Felix Schaeffler Journal of Medical Engineering & Technology16:5 (204-209)1 Jan 1992An intra-oral access deviceC. J. Clayton Language Teaching14:1-3 (73-89)1 Apr 1981Speech ResearchFrancis Nolan The Journal of Prosthetic Dentistry40:1 (60-66)1 Jul 1978Conditioning prostheses viewed from the standpoint of speech adaptationSandra Hamlet, Maureen Stone and Thomas McCarty The Journal of Prosthetic Dentistry27:4 (364-376)1 Apr 1972Dynamic palatography—A study of linguopalatal contacts during the production of selected consonant soundsWilliam T. Harley Volume 29Issue 4November 1964Pages: 489-492 Get Permissions Add to your Mendeley library HistoryReceived: Jan 23, 1964 Published in issue: Nov 1, 1964PubMed ID: 14257051 Metrics Topicsasha-article-typesCopyright & PermissionsCopyright © 1964 American Speech-Language-Hearing AssociationPDF downloadLoading ...
Repulsive interactions between magnetic bubbles: Consequences for bubble devices (1971)

Experiments and calculations are reported about some aspects of the repulsive interactions of cylindrical magnetic bubble domains. Experiments were done on hexagonal lattices of bubbles in which, for one case, the stable positions of the bubbles were determined by a Permalloy overlay. The calculations refer to different structures and Show that from a point of view of bubble interactions the maximum bubble density for a square lattice is almost the same as for a hexagonal lattice. It is also shown that a preferred thickness of the bubble material sheet exists.
Microbiological status of root‐filled teeth with apical periodontitis (1998)

The present study examined the microbiological status of 100 root-filled teeth with radiographically verified apical periodontitis--the pathology (P) group--and of 20 teeth without signs of periapical pathosis--the technical (T) group. In the P group 117 strains of bacteria were recovered in 68 teeth. In most of the cases examined one or two strains were found. Facultative anaerobic species predominated among these isolates (69% of identified strains). Growth was classified as 'sparse' or 'very sparse' in 53%, and as 'heavy' or 'very heavy' in 42%. Enterococci were the most frequently isolated genera, showing 'heavy' or 'very heavy' growth in 25 out of 32 cases (78%). In 11 teeth of the T group no bacteria were recovered, whilst the remaining nine yielded 13 microbial strains. Eight of these grew 'very sparsely'. It is concluded that the microflora of the obturated canal differs from that found normally in the untreated necrotic dental pulp, quantitatively as well as qualitatively. Nonsurgical retreatment strategies should be reconsidered.
Stimulated Growth and Innate Immunity in Brook Charr (Salvelinus fontinalis) Treated with a General Probiotic (Bactocell®) and Two Endogenous Probiotics That Inhibit Aeromonas salmonicida In Vitro (2019)

<i>Aeromonas salmonicida</i> subsp. <i>salmonicida</i> is a Gram-negative bacterium causing furunculosis, an opportunistic infection of farmed salmonid fish. Current treatment methods against furunculosis rely heavily on antibiotherapy. However, strains of this opportunistic fish pathogen were found to possess genes that confer resistance to major antibiotics including those used to cure furunculosis. Therefore, dispensing bacterial symbionts as probiotics to susceptible hosts appears to be a promising alternative. Here, we present the genomic characterization and in vivo safety assessment of two brook charr (<i>Salvelinus fontinalis</i>) bacterial symbionts that inhibited <i>A.</i> <i>salmonicida</i> subsp. <i>salmonicida</i> growth in vitro (<i>Pseudomonas fluorescens</i> ML11A and <i>Aeromonas sobria</i> TM18) as well as a commercialized probiotic, <i>Pediococcus acidilactici</i> MA18/5M (Bactocell<sup>®</sup>). The genomic sequences of ML11A and TM18 obtained by whole-genome shotgun sequencing lack key virulence factor genes found in related pathogenic strains. Their genomic sequences are also devoid of genes involved in the inactivation (or target modification of) several key antimicrobial compounds used in salmonid aquaculture. Finally, when administered daily to live brook charr fingerlings, ML11A, TM18 and Bactocell<sup>®</sup> helped improve several physiological condition metrics such as mean body weight, Fulton's condition factor and blood plasma lysozyme activity (an indicator for innate immune activity).
Angiomyolipoma arising in the colon. (1996)

Extrarenal angiomyolipomas are very rare. Here we report the first case of surgically resected angiomyolipoma of the descending colon that developed in a 50-yr-old man. The patient had no signs of or family history of tuberous sclerosis. He underwent a partial colectomy because the tumor obstructed the colon. Histologically, the tumor consisted of three components: mature fat cells, blood vessels, and smooth muscle cells, and was thereby diagnosed as an angiomyolipoma. Immunohistochemically, the proliferating smooth muscle cells were positive for vimentin, alpha-smooth muscle actin, and desmin. The tumor cells were negative for HMB-45, which is consistently expressed in renal angiomyolipomas.