gebhart/patrepeval huggingface dataset:
High-pressure form of palladium disulfide (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh-pressure form of palladium disulfideRonald A. Munson and John S. KasperCite this: Inorg. Chem. 1969, 8, 5, 1198–1199Publication Date (Print):May 1, 1969Publication History Published online1 May 2002Published inissue 1 May 1969https://doi.org/10.1021/ic50075a041RIGHTS & PERMISSIONSArticle Views136Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (243 KB) Get e-Alerts Get e-Alerts
Endolysins of <i>Bacillus anthracis</i> Bacteriophages Recognize Unique Carbohydrate Epitopes of Vegetative Cell Wall Polysaccharides with High Affinity and Selectivity (2012)

Bacteriophages express endolysins which are the enzymes that hydrolyze peptidoglycan resulting in cell lysis and release of bacteriophages. Endolysins have acquired stringent substrate specificities, which have been attributed to cell wall binding domains (CBD). Although it has been realized that CBDs of bacteriophages that infect Gram-positive bacteria target cell wall carbohydrate structures, molecular mechanisms that confer selectivity are not understood. A range of oligosaccharides, derived from the secondary cell wall polysaccharides of Bacillus anthracis, has been chemically synthesized. The compounds contain an α-d-GlcNAc-(1→4)-β-d-ManNAc-(1→4)-β-d-GlcNAc backbone that is modified by various patterns of α-d-Gal and β-d-Gal branching points. The library of compounds could readily be prepared by employing a core trisaccharide modified by the orthogonal protecting groups N(α)-9-fluorenylmethyloxycarbonate (Fmoc), 2-methylnaphthyl ether (Nap), levulinoyl ester (Lev) and dimethylthexylsilyl ether (TDS) at key branching points. Dissociation constants for the binding the cell wall binding domains of the endolysins PlyL and PlyG were determined by surface plasmon resonance (SPR). It was found that the pattern of galactosylation greatly influenced binding affinities, and in particular a compound having a galactosyl moiety at C-4 of the nonreducing GlcNAc moiety bound in the low micromolar range. It is known that secondary cell wall polysaccharides of various bacilli may have both common and variable structural features and in particular differences in the pattern of galactosylation have been noted. Therefore, it is proposed that specificity of endolysins for specific bacilli is achieved by selective binding to a uniquely galactosylated core structure.
An intellectual property module for auto-calibration of time-interleaved pipelined analog-to-digital converters (2004)

A flexible digital intellectual property (IP) module that controls the auto-calibration of time interleaved pipelined ADCs is presented. It takes advantage of a judicious combination of classical calibration techniques to determine, in an adaptive way, the adequate compensation of gain and offset for each stage of interleaved pipelined ADCs. A novel built-in self-test (BIST) is also included in the IP. Preliminary simulation results confirm the expected behavior of the calibration method. This soft IP was designed and synthesized.
Evaluating maximum photovoltaic integration in district distribution systems considering optimal inverter dispatch and cloud shading conditions (2016)

As photovoltaic (PV) integration increases in distribution systems, to investigate the maximum allowable PV integration capacity for a district distribution system becomes necessary in the planning phase, an optimisation model is thus proposed to evaluate the maximum PV integration capacity while guaranteeing the entire system operating constraints (e.g. network voltage magnitude) within reasonable ranges in this study. Meanwhile, optimal inverter dispatch is employed to further improve the PV integration by ensuring the optimal set‐points of both active power and reactive power for the PV inverters. However, the intermittency of solar PV energy (e.g. due to passing clouds) may affect the PV generation in the district distribution network. To address this issue, the voltage magnitude constraints under the cloud shading conditions should be taken into account in the optimisation model, which can be formulated as a mixed integer non‐linear non‐convex programming. Furthermore, a sequential interior‐point method is utilised to solve this problem. Case studies on the IEEE 33‐bus, 69‐bus distribution networks and two practical distribution networks in China demonstrate the effectiveness of the proposed method.
Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase (2013)

All positive-stranded RNA viruses with genomes>∼7 kb encode helicases, which generally are poorly characterized. The core of the nidovirus superfamily 1 helicase (HEL1) is associated with a unique N-terminal zinc-binding domain (ZBD) that was previously implicated in helicase regulation, genome replication and subgenomic mRNA synthesis. The high-resolution structure of the arterivirus helicase (nsp10), alone and in complex with a polynucleotide substrate, now provides first insights into the structural basis for nidovirus helicase function. A previously uncharacterized domain 1B connects HEL1 domains 1A and 2A to a long linker of ZBD, which further consists of a novel RING-like module and treble-clef zinc finger, together coordinating three Zn atoms. On substrate binding, major conformational changes were evident outside the HEL1 domains, notably in domain 1B. Structural characterization, mutagenesis and biochemistry revealed that helicase activity depends on the extensive relay of interactions between the ZBD and HEL1 domains. The arterivirus helicase structurally resembles the cellular Upf1 helicase, suggesting that nidoviruses may also use their helicases for post-transcriptional quality control of their large RNA genomes.
Mutations of the Drosophila myosin heavy-chain gene: effects on transcription, myosin accumulation, and muscle function. (1986)

Mutations of the myosin heavy-chain (MHC) gene of Drosophila melanogaster were identified among a group of dominant flightless and recessive lethal mutants (map position 2-52, 36A8-B1,2). One mutation is a 0.1-kilobase deletion in the 5' region of the MHC gene and reduces MHC protein in the leg and thoracic muscles of heterozygotes to levels found in 36AC haploids. Three mutations are insertions of 8-to 10-kilobase DNA elements within the MHC gene and produce truncated MHC transcripts. Heterozygotes of these insertional mutations possess levels of MHC intermediate between those of haploids and diploids. An additional mutation has no gross alteration of the MHC gene or its RNA transcripts. Although leg and larval muscles function normally in each mutant heterozygote, indirect flight muscles are defective and possess disorganized myofibrils. Homozygous mutants die during embryonic or larval development and display abnormal muscle function prior to death. These findings provide direct genetic evidence that the MHC gene at 36B (2L) is essential for both larval and adult muscle development and function. The results are consistent with the previous molecular evidence that Drosophila, unlike other organisms, has only a single muscle MHC gene per haploid genome. Quantitative expression of both copies of the MHC gene is required for function of indirect flight muscle, whereas expression of a single MHC gene is sufficient for function of larval muscles and adult tubular muscles.
The Effect of the 3.3.5.5 Walking Club Program to Health Promotion of the Elderly (2008)

Purpose: We had executed the 3 3 5 5 walking club program for 12 weeks for one hour three times per week to evaluate the effect of the program on health of the elderly. Methods: A pre and post measurement tool of the program was applied to measure obesity, rate of body fat, blood pressure, vital capacity, standard vital capacity, intake capacity of maximum oxygen, grasping power, reaction of whole body, pulse, body mass index (BMI), total bodily score, age of bodily strength, age of health. Data collected from this tool was analyzed by SPSS in paired t-test. Results: The 3 3 5 5 walking club program has affected the weight control of the participants. The participants of 3 3 5 5 walking club program reduced their weight from 61.7 kg to 61.25 kg, rate of body fat from 21.89 kg to 21.22 kg, standard vital capacity from 2,393.56 ml to 2,380.44 ml, reaction of whole body from 475.38 msec to 439.33 msec, and increased grasping power from 22.06 to 23.16 ml (p
Diagnosis of Endolymphatic Hydrops by Low-Frequency Masking (1996)

Low-frequency masking is a new method for the diagnosis of endolymphatic hydrops. A short acoustic stimulus and a low-frequency masker tone are applied to the same ear in an adjustable phase relationship. We recorded phase-dependent masked thresholds from normal-hearing subjects, and patients with Ménière's disease and sensory hearing loss without vertigo. In normal hearing, there is a mean maximal difference in masking (modulation depth) of 28 dB between the phase delays of 0 degree and 270 degrees. In patients with sensory hearing loss without vertigo, modulation depth is reduced due to recruitment. In Ménière cases, the phase dependence may be totally absent and varies as the disease progresses. Therefore, repeated measurements of masking are required: patients and subjects with normal hearing were tested for a period of 1 year. Also, modulation depth is significantly reduced in the contralateral nonsymptomatic ears of Ménière patients. The results indicate that low-frequency masking is a quick, noninvasive and relevant method for the diagnosis of endolymphatic hydrops.
Cytosolic phospholipase A2 and its mode of activation in human neutrophils by opsonized zymosan: Correlation between 42/44 kDa mitogen-activated protein kinase, cytosolic phospholipase A2 and NADPH oxidase (1997)

The role of cytosolic phospholipase A2 (cPLA2) and its mode of activation by opsonized zymosan (OZ) was studied in human neutrophils in comparison with activation by PMA. The activation of cPLA2 by 1 mg/ml OZ or 50 ng/ml PMA is evidenced by its translocation to the membrane fractions on stimulation. This translocation is consistent with dithiothreitol (DTT)-resistant phospholipase A2 (PLA2) activity detected in the membranes of activated cells. Neutrophils stimulated by either OZ or PMA exhibited an immediate stimulation of extracellular-signal-regulated kinases (ERKs). The inhibition of ERKs, DTT-resistant PLA2 and NADPH oxidase activities by the MAP kinase kinase inhibitor PD-98059 indicates that ERKs mediate the activation of cPLA2 and NADPH oxidase stimulated by either OZ or PMA. The protein kinase C (PKC) inhibitor GF-109203X inhibited epidermal growth factor receptor peptide kinase activity, the release of [3H]arachidonic acid, DTT-resistant PLA2 activity and superoxide generation induced by PMA, but did not inhibit any of these activities induced by OZ. PKC activity was similarly inhibited by GF-109203X in membrane fractions separated from neutrophils stimulated by either PMA or OZ. In the presence of the tyrosine kinase inhibit orgenistein, ERKs, PLA2 and NADPH oxidase activities were inhibited in cells stimulated by OZ, whereas they were hardly affected in cells stimulated by PMA. The results suggest that the activation of cPLA2 by PMA or OZ is mediated by ERKs. Whereas PMA stimulates ERKs activity through a PKC-dependent pathway, signal transduction stimulated by OZ involves tyrosine kinase activity leading to activation of ERKs via a PKC-independent pathway.
A method to account for window birefringence effects on ellipsometry analysis (1993)

Accurate knowledge of ellipsometric parameters of material surfaces is important for determination of optical properties of bare surfaces, thickness and refractive index of thin films and for study of transport phenomena in ultra-thin films. In this study an analytical framework, in the context of Fourier coefficients, is presented that allows window birefringence to be incorporated in the analysis of ellipsometric measurements. The method is applied to analysis of data obtained on an amorphous carbon sample in the wavelength range 400-700 nm at temperature 25 degrees C. It is demonstrated that the inferred refractive indices of the sample may be in error by 28% or more when birefringence effects are not included in the analysis. Thus, when ellipsometry is to be used for inference of refractive indices, film thickness and/or transport properties of thin films deposited on solid surfaces, window birefringence effects may not be neglected.
Silicon VLSI/ferroelectric liquid crystal technology for micropower optoelectronic computing devices (1990)

Optoelectronic computing devices with high circuit complexity and a favorable speed-power product can be realized by fabricating a liquid crystal light modulating layer atop a conventional silicon die.
Is a mechanism such as the NCI's Clinical Alert ever an appropriate alternative to journal peer review? (1991)

Responsibly handled, a mechanism such as a Clinical Alert can provide physicians with enough information to deal with the early release of data to the public. The journal peer review system was established primarily as an academic tool to allow publication of scientific work for the purpose of communicating information among scientists and physicians. Since both the number of papers published by an investigator and the quality of the journal publishing them are important to academic advancement, bypassing this system naturally threatens many physicians and scientists. The Clinical Alert, however, served its purpose and was well received by the majority of practicing physicians and the public. In fact, a second Alert was issued by NCI in October 1989 when data became available on the effectiveness of a new adjuvant drug therapy for a common stage of colon cancer (Appendix B) and, at a workshop convened by the National Cancer Advisory Board, where the mechanism of the Clinical Alerts was discussed, it was apparent that most participants felt that maintaining this process was important. In light of the current revolution in biology, the public's interest in receiving the benefits of its financial support of the national research enterprise, and access by the press to both scientific literature and meetings, it seems appropriate for public officials, especially when mandated by Congress, to take the responsibility of releasing some types of data to the public before traditional peer review. Some visible public decision-making process must, however, be used where the pros and cons of early release of a particular data set can be discussed, as was done with the original NCI Clinical Alert.(ABSTRACT TRUNCATED AT 250 WORDS)
Nitric oxide inhibits steroidogenesis in cultured porcine granulosa cells (1997)

Recent evidence suggested that nitric oxide (NO) acts as an important factor in a variety of physiological and pathological roles, including reproductive functions. The purpose of the present study was to investigate whether NO might significantly induce any change in steroidogenesis in cultured porcine granulosa cells (PGC). An NO donor, NOC18, significantly suppressed the oestradiol release from basal (unstimulated) and gonadotrophin-stimulated PGC in a 2 h culture. NOC18 also significantly inhibited the aromatase activity of basal and gonadotrophin-stimulated PGC as measured by a modified tritiated water method. However, the cGMP analogue, 8-bromo-cGMP, had no significant effect on the accumulation of oestradiol and progesterone in basal and gonadotrophin-stimulated PGC during 24 h culture. An NO synthase (NOS) inhibitor, NG-monomethyl-L-arginine (LNMMA), significantly stimulated the basal oestradiol release and dose-dependently enhanced the oestradiol and progesterone release from follicle stimulating hormone (FSH)-stimulated PGC in a 24 h culture. However, NG-monomethyl-D-arginine, which does not inhibit NOS, did not enhance the release of oestradiol and progesterone under the same experimental conditions. LNMMA also significantly suppressed the nitrite concentrations in the media as measured by chemiluminescence. These results demonstrate for the first time that NO inhibits oestradiol secretion independent of cGMP by inhibiting P450 aromatase activity in moderately mature PGC.
Cyclic [6]‐ and [8]Paraphenylacetylenes (1996)

The belt-shaped, conjugated molecules 1 and 2 were synthesized by bromination–dehydrobromination of the corresponding hexaene and octaene. The air-sensitive but isolable compounds show appreciable strain in the triple bonds and large Stokes shifts in the emission spectra.
BladeCenter systems management software (2005)

The management software for the IBM eServer™ BladeCenter® platform combines multiple management tools and technologies to create an integrated solution for managing, configuring, and deploying the chassis components and attached storage area networks. The IBM software also integrates BladeCenter platform management capabilities with other enterprise system management tools. This paper describes the architecture and capabilities of the IBM Director, Cluster Systems Manager, and Virtualization Engine™ tools, which enable customers to configure, manage, and provision the BladeCenter system. These tools configure and monitor the chassis using out-of-band communications with the BladeCenter management module. Management agents installed on each processor blade provide in-band operating system monitoring and integration into enterprise management applications, such as IBM Tivoli® software. This paper includes a description of the management technologies and design innovations that assist the system administrator with management tasks such as discovery, blade and switch module configuration, asset inventory, out-of-band control, alerting and event actions, storage configuration, operating system installation, application deployment, and provisioning.
Sequences Downstream of the Translation Initiation Codon Are Important Determinants of Translation Efficiency in Chloroplasts (2001)

The objective of this study was to determine if mRNA sequences downstream of the translation initiation codon are important for translation of plastid mRNAs. We have employed a transgenic approach, measuring accumulation of the neomycin phosphotransferase (NPTII) reporter enzyme translationally fused with 14 N-terminal amino acids encoded in the rbcL or atpB plastid genes. NPTII accumulation from wild-type and mutant rbcL and atpB segments was compared. We report that silent mutations in the rbcL segment reduced NPTII accumulation 35-fold. In contrast, mutations in the atpB mRNA reduced NPTII accumulation only moderately from approximately 7% (w/w) to approximately 4% (w/w) of the total soluble cellular protein, indicating that the importance of sequences downstream of the translation initiation codon are dependent on the individual mRNA. Information provided here will facilitate transgene design for high-level expression of recombinant proteins in chloroplasts by translational fusion with the N-terminal segment of highly expressed plastid genes or by introduction of silent mutations in the N-terminal part of the coding region.
Emerging drugs to treat squamous cell carcinomas of the head and neck (2010)

The head and neck cancer drug market is rapidly evolving. Coordination between drug and biomarker development efforts may soon yield targeted therapies that can achieve the promise of personalized cancer medicine.
Apoptosis is induced by curcumin in synergism with 5FU in human colorectal cancer cell line. (2014)

Background: Curcumin, a phenolic derived from the rhizome of the Curcuma longa linn ( Zingi-beraceae ), has been recognized as a promising anti-cancer drug due to its multiple properties, including anti-inflammatory,antioxidant and anti-angiogenic. Also some evidences show its' anti-cancer effect in some malignancies as in colon, prostate and breast cancer. To show better, the role of curcumin in colon cancer and apoptosis in comparison with 5flurouracil (5-FU) we have planned this project. Material and methods: For Proliferation test we used MTT assay and for apoptosis study we used TUNEL assay. Also 5FU has been provided as positive control Results: Our experiment has shown that curcumin, in a dose-dependent manner, reduces cell viability and increases apoptosis in HT29, SW480 and SW742 colorectal cancer cell lines as analyzed by MTT and TUNEL assay, respectively. Moreover, combined with 5FU synergistically increased the number of hypodiploid cells and DNA fragmentation and decreased cell viability in all colorectal cancer cell lines. This study demonstrates that adding curcumin to 5FU have a synergic anti-mitogenic and apoptotic effect on colorectal cancer cell lines. These results suggest a potential use of serotonin 5-HT 2A receptor antagonist in co-treatment with curcumin in colon cancer therapy.
논문 ; 축산물 가공 : 축육제품의 유통구조 및 저장성 개선에 관한 연구 ; 1 . 유통구조 개선 (1991)

This studies was carried out to study a current status of Korean meat product market and thereby to suggest reasonable modifications for marketing system of meat products. The following modifications are strongly demanded to improved current marketing scheme of the processed meat products. 1. Different pricing system of raw meat, based on their part and grade, should be practised as soon as possible to improve qualities of both raw meat and meat product. 2. Supply contract between meat producer and processor should be established through integrated production scheme and therefore it make it possible to get a complete quality improvement from raw meat to final product. 3. Any quality deterioration should be prevented through a modernization of slaughter house and good sanitation practice. 4. Both meat processors and marketing industry primarily should cooperate to practice and stabilize the cold chain system. 5. Sound competition through an improvement in technology and advertisement for the consumer should be encouraged.
Movement artefact rejection in impedance pneumography using six strategically placed electrodes (2000)

In this paper, we have proposed a technique for reducing movement artefacts in impedance pneumography by placing six electrodes at appropriate locations and suitably combining the measurements obtained. The strategy for electrode placement was based on the observation that the electrodes appeared to slide over the rib cage along with the skin, during movement. A volume conductor model of the thoracic cavity was developed and movement artefacts were simulated by shifting the electrodes to a different location on the surface. The impedance changes due to movement in one of the measurements of a 'symmetrical pair' were 180 degrees out of phase with respect to those observed in the other measurement of that pair. However, the impedance changes due to breathing were in phase in both these measurements. Thus, it was possible to reduce movement artefacts by taking a mean of these measurements without affecting the breathing related changes. The six electrodes could be configured into two such symmetrical pairs. The same observation was made in experimental data recorded from human subjects. This indicated that movement artefacts were caused by sliding of electrodes along with the skin and could be reduced by using the six-electrode configuration.