gebhart/patrepeval huggingface dataset:
El entorno histórico económico de la evolución contable colegiada en Sonora, México. (1925-1994) (2016)

La vida colegiada de los contadores públicos, es una fuente importante de la historia moderna de la contabilidad en México, ya que el análisis y recapitulación de su trayectoria manifiesta momentos históricos de la profesión, a la vez que acumula acciones y comportamientos que hablan de la vida económica de su contexto en un tiempo y momento. Durante años México, ha tenido una fuerte influencia cultural y de inversión de su vecino norteamericano: EUA, en ello la contabilidad no ha permanecido ajena, de forma que el modelo continental anglosajón (Choi citado por De la Rosa, 2000: 15), que distingue a EUA es seguido históricamente por México en una adaptación ad hoc con una relación teórica permanente, que enfrenta un dilema dual por un lado el beneficio inmediato de modernización y actualización de su estructura teórica contable; y por otro la diferencia cultural y de tipo de negocios que operan en México, que en algunos momentos hace inoperable conceptos contables sajones. No obstante, se observa en la policromía cultural de México, como la tendencia del ejercicio profesional contable con lleva importantes grados de especialización y sofisticación tecnológica, en busca de generar información contable de la imagen fiel basada en normas reguladas por organismos profesionales exprofeso, en particular los Colegios de Contadores y el Instituto Mexicano de Contadores Públicos. En este trabajo, utilizando un análisis biográfico, documental y de caso, se presenta un extracto del hallazgo histórico de correlación entre el desarrollo contable del estado de Sonora en México y los distintos momentos económicos que los enmarcaron, comentando en cada periodo los cambios y especializaciones que se dieron. A fin de permitir conocer un panorama del camino, circunstancias, condiciones y peculiaridades de la contabilidad regional en una historia contemporánea.
Programmable CRISPR-responsive smart materials (2019)

Stimuli-responsive materials activated by biological signals play an increasingly important role in biotechnology applications. We exploit the programmability of CRISPR-associated nucleases to actuate hydrogels containing DNA as a structural element or as an anchor for pendant groups. After activation by guide RNA-defined inputs, Cas12a cleaves DNA in the gels, thereby converting biological information into changes in material properties. We report four applications: (i) branched poly(ethylene glycol) hydrogels releasing DNA-anchored compounds, (ii) degradable polyacrylamide-DNA hydrogels encapsulating nanoparticles and live cells, (iii) conductive carbon-black-DNA hydrogels acting as degradable electrical fuses, and (iv) a polyacrylamide-DNA hydrogel operating as a fluidic valve with an electrical readout for remote signaling. These materials allow for a range of in vitro applications in tissue engineering, bioelectronics, and diagnostics.
Traitor tracing schemes for protected software implementations (2011)

This paper considers the problem of converting an encryption scheme into a scheme in which there is one encryption process but several decryption processes. Each decryption process is made available as a protected software implementation (decoder). So, when some digital content is encrypted, a legitimate user can recover the content in clear using its own private software implementation. Moreover, it is possible to trace a decoder in a black-box fashion in case it is suspected to be an illegal copy. Our conversions assume software tamper-resistance.
Versatile Graphene Oxide Putty‐Like Material (2016)

Versatile graphene oxide putty-like material (GOP) with excellent processability is developed by mediating a graphene oxide suspension with aniline. Arbitrarily predesigned architectures on both microscopic and macroscopic scales can be molded easily. GOP cannot only be used as starting material for direct 3D printing of particular configurations, but also can be tailored into the patterned structures on various substrates for large-scale production of device arrays.
Copper and Its Complexes in Medicine: A Biochemical Approach (2011)

The fundamental role of copper and the recognition of its complexes as important bioactive compounds in vitro and in vivo aroused an ever-increasing interest in these agents as potential drugs for therapeutic intervention in various diseases. The vast array of information available for their bioinorganic properties and mode of action in several biological systems, combined with the new opportunities offered by the flourishing technologies of medicinal chemistry, is creating an exciting scenario for the development of a novel generation of highly active drugs with minimized side effects which could add significantly to the current clinical research and practice. In this paper we attempt to summarize all the available-to-date information on these issues.
Directional Invariance of Co-occurrence Matrices within the Liver (2008)

Co-occurrence matrices are one of three texture algorithms commonly used on computed tomography (CT) images. In this paper we analyze the directional invariance of Co-occurrence matrices for the purpose of reducing their runtime by reducing the number of directions analyzed without negatively affecting the quality of the texture data extracted.
<title>Fiber optic interferometry for industrial process monitoring and control applications</title> (2002)

Over the past few years we have been developing applications for a high-resolution (sub-micron accuracy) fiber optic coupled dual Michelson interferometer-based instrument. It is being utilized in a variety of applications including monitoring liquid layer thickness uniformity on coating hoppers, film base thickness uniformity measurement, digital camera focus assessment, optical cell path length assessment and imager and wafer surface profile mapping. The instrument includes both coherent and non-coherent light sources, custom application dependent optical probes and sample interfaces, a Michelson interferometer, custom electronics, a Pentium-based PC with data acquisition cards and LabWindows CVI or LabView based application specific software. This paper describes the development evolution of this instrument platform and applications highlighting robust instrument design, hardware, software, and user interfaces development. The talk concludes with a discussion of a new high-speed instrument configuration, which can be utilized for high speed surface profiling and as an on-line web thickness gauge.
Self-Assembly of Ibuprofen and Bovine Serum Albumin−Dextran Conjugates Leading to Effective Loading of the Drug (2009)

A simple and green process of simultaneous formation of albumin nanoparticles and encapsulation of hydrophobic drugs in aqueous solution was developed. Bovine serum albumin (BSA)-dextran conjugates were prepared through the Maillard reaction. Ibuprofen was used as a drug model. The solubility of protonated ibuprofen decreases, and then precipitation occurs when the pH of saturated ibuprofen solution is changed from alkali to acidic value. In the presence of the conjugates, a binding of ibuprofen with BSA through hydrophobic and electrostatic interactions can suppress the precipitation of ibuprofen. After a heat treatment, the gelation of BSA results in the formation of nanoparticles and fixing of the ibuprofen in the core. The nanoparticles were characterized with dynamic and static light scattering, zeta-potential, and transmission electron microscopy. The nanoparticles are of spherical shape having a hydrodynamic diameter of about 70 nm. As much as 0.7 unit weight of ibuprofen can be loaded into one unit weight of the conjugates. The dextran conjugated to BSA stabilizes the nanoparticles in aqueous solution.
Enhanced Recovery of Injury-Caused Downregulation of Paxillin Protein by eNOS Gene Expression in Rat Carotid Artery (1999)

Injury-caused dedifferentiation accompanied by proliferation and migration of smooth muscle cells (SMCs) is an important process in the development of the neointima. Nitric oxide (NO) stimulates differentiation and inhibits proliferation and migration of SMCs. Paxillin has been found to play an important role in cell differentiation, and its phosphorylation is regulated by NO in cultured SMCs. However, the regulation of paxillin by NO in the injured artery has not been investigated. Therefore, the aim of this study was to study the effects of in vivo endothelial NO synthase (eNOS) gene transfection on paxillin expression and intimal hyperplasia. A catheter balloon-denuded rat carotid artery was transfected in vivo with the replication-deficient adenovirus Ad5/RSVeNOS or with Ad5/RSVLacZ as the control. Transfected eNOS gene expression was determined by immunostaining, Western blot analysis, and citrulline assay. The expression of paxillin and its associated proteins was determined in injured arteries by Western blot analysis. The area of the intima and the ratio of intima to media were examined on cross sections by morphometry. The data showed that the expression of paxillin was significantly downregulated after injury. eNOS gene transfer showed no effect on paxillin downregulation 2 days after injury but significantly enhanced the recovery of paxillin protein 5 days and 2 weeks after injury. Vinculin, a paxillin-binding protein, was not altered by vascular injury or by eNOS gene transfer. eNOS gene transfer significantly inhibited intimal hyperplasia for up to 4 weeks. These results suggest that NO inhibition of intimal hyperplasia may be mediated by enhancing the recovery of injury-caused downregulation of paxillin.
Collaborative processing of data-intensive algorithms with CPU, intelligent SSD, and GPU (2016)

The graphic processing unit (GPU) is a computing resource to process graphics-related applications. The intelligent SSD (iSSD) is a solid state device (SSD) that is provided with data processing power. These days, CPU, GPU, and SSD are equipped together in most processing environment. If SSD is replaced with iSSD later on, we have a new processing environment where three computing resources collaborate one another to process a huge volume of data (so called big data) quite effectively. In this paper, we address how to exploit all these computing resources for efficient processing of data-intensive algorithms.Through extensive experiment, we verify the effectiveness and potential of the proposed collaborative processing environment by processing data concurrently with multiple computing resources. The results reveal that processing in the our environment outperforms that in the traditional one by up to 3.5 times.
Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein. (1992)

The human Pur factor binds strongly to a sequence element repeated within zones of initiation of DNA replication in several eukaryotic cells. The protein binds preferentially to the purine-rich single strand of this element, PUR. We report here the cloning and sequencing of a cDNA encoding a protein with strong affinity for the PUR element. Analysis with a series of mutated oligonucleotides defines a minimal single-stranded DNA Pur-binding element. The expressed Pur open reading frame encodes a protein of 322 amino acids. This protein, Pur alpha, contains three repeats of a consensus motif of 23 amino acids and two repeats of a second consensus motif of 26 amino acids. Near its carboxy terminus, the protein possesses an amphipathic alpha-helix and a glutamine-rich domain. The repeat region of Pur cDNA is homologous to multiple mRNA species in each of several human cell lines and tissues. The HeLa cDNA library also includes a clone encoding a related gene, Pur beta, containing a version of the 23-amino-acid consensus motif similar, but not identical, to those in Pur alpha. Results indicate a novel type of modular protein with capacity to bind repeated elements in single-stranded DNA.
Enteric Microflora in IBD: Pathogens or Commensals? (1997)

Both pathogenic and normal enteric microflora can induce and perpetuate chronic intestinal inflammation with systemic manifestations in genetically susceptible hosts. At the present time, there is no convincing indication that the majority of cases of ulcerative colitis or Crohn's disease is caused by persistent infection by Mycobacterium paratuberculosis, measles, Listeria monocytogenes, or Helicobacter species, but this possibility remains a valid hypothesis. Transient infection with any of a number of pathogens including upper respiratory tract infections and common enteric pathogens could provide one of the environmental triggers that initiate or reactivate IBD, which is then perpetuated in susceptible hosts by resident (not pathogenic) commensal luminal bacteria. Recent results in animal models demonstrate the absence of colitis, gastritis, and arthritis in a sterile (germ-free) environment, showing the importance of resident bacteria as persistent antigenic stimuli in the genetically susceptible hosts. Furthermore, there is an indication that not all normal luminal bacteria have equal capacities to induce mucosal injury, since some species can induce inflammation (Bacteroides), some are neutral (E. coli) and others may be protective (Lactobacilli). These observations have important therapeutic implications, such that altering luminal bacterial components and thereby decreasing the persistent antigenic drive offer alternative or adjuvant approaches to ongoing efforts to block mucosal immune responses to these stimuli.
Regulation of translation initiation factor gene expression during human T cell activation. (1992)

Activation of quiescent T cells leads to a dramatic increase in the rate of protein synthesis. It is believed that this pronounced increase of protein synthesis is regulated primarily at the level of translational initiation. Although considerable evidence demonstrates that translational initiation can be regulated at the post-translational level by the phosphorylation/dephosphorylation of translation initiation factors (eIFs) such as eIF-4E and eIF-2 alpha, additional mechanisms of eIF gene expression may also play a role in the regulation of translation in quiescent cells and/or during their subsequent induction to enter the cell cycle. To address this issue, gene expression of eIF-2 alpha, -4E, and -4A was studied in quiescent human peripheral blood T cells following stimulation through the T cell receptor-CD3 complex. Quiescent T cells expressed low levels of eIF-2 alpha, -4E, and -4A mRNAs and proteins as compared to proliferating T cells. Activation of resting T cells resulted in a rapid increase (20-50-fold) in the levels of these three mRNAs. This increase did not require new protein synthesis. Furthermore, transcription rates of these three eIF genes showed only minor increase over the induction period as measured by nuclear run-on assays. Despite the rapid increase in initiation factor mRNA levels, increases in eIF protein levels lagged significantly behind. Western blot analysis also showed that the protein levels of the three eIFs were differentially increased. eIF-4A protein levels increased in proportion to the observed increase in cellular protein synthetic activity while the increases in eIF-4E and eIF-2 alpha proteins were proportionately less. The low levels of eIF proteins in quiescent T cells appear to correlate with low protein synthesis rate in such cells. The induction of eIF proteins by post-transcriptional/translational mechanisms appears to contribute to the pronounced stimulation of protein synthesis that occurs during T cell activation.
HLA Mismatch Is Associated with Worse Outcomes after Unrelated Donor Reduced-Intensity Conditioning Hematopoietic Cell Transplantation: An Analysis from the Center for International Blood and Marrow Transplant Research (2015)

Over the past 2 decades, reduced-intensity conditioning allogeneic hematopoietic cell transplantation (RIC HCT) has increased substantially. Many patients do not have fully HLA-matched donors, and the impact of HLA mismatch on RIC HCT has not been examined in large cohorts. We analyzed 2588 recipients of 8/8 HLA-high resolution matched (n = 2025) or single-locus mismatched (n = 563) unrelated donor (URD) RIC HCT from 1999 to 2011. Overall survival (OS) was the primary outcome. Secondary endpoints included treatment-related mortality (TRM), relapse, disease-free survival (DFS), and acute/chronic graft-versus-host disease (GVHD). Adjusted 1- and 3-year OS was better in 8/8- versus 7/8-matched recipients (54.7% versus 48.8%, P = .01, and 37.4% versus 30.9%, P = .005, respectively). In multivariate models 7/8 URD RIC HCT recipients had more grades II to IV acute GVHD (RR = 1.29, P = .0034), higher TRM (RR = 1.52, P < .0001), and lower DFS (RR = 1.12, P = .0015) and OS (RR = 1.25, P = .0001), with no difference in relapse or chronic GVHD. In subgroup analysis, inferior transplant outcomes were noted regardless of the HLA allele mismatched. Previously reported permissive mismatches at HLA-C (C*03:03/C*03:04) and HLA-DP1 (based on T cell-epitope matching) were not associated with better outcomes. Although feasible, single-locus mismatch in RIC URD HCT is associated with inferior outcomes.
Studies on Persicae Semen. III. Oxygen Radical Scavenging Activity of PR-B, an Anti-inflammatory Protein of Persicae Semen (1985)

PR-B is a protein composition of Persicae semen (mol. wt.=about 10000) ; and its antiinflammatory activity is comparable to that of indomethacin in the carrageenin-induced hind paw edema test. In order to explore the mode of anti-inflammatory action of PR-B, inhibitory activities of PR-B on kinin-release by kallikrein and superoxide anion production were investigated in vitro. PR-B produced a dose-related inhibition of kinin-release by kallikrein at concentrations of 10-5-10-3M, and its potency (IC50=1.4×10-4M) was comparable to that of soybean trypsin inhibitor (SBTI) ; superoxide dismutase (SOD) and N-α-p-tosyl-L-lysine-chrolomethylketone, a synthetic trypsin inhibitor were inactive. The potency of PR-B as a trypsin inhibitor (IC50=3.2×10-4 M or more than 104- M) was much weaker than that of SBTI (IC50=7.2 or 7.4×10-8M) ; SOD was inactive. In contrast to those activities, PR-B had comparatively strong SOD-like activity ; i.e., PR-B inhibited dose-relatedly the superoxide anion production by peritoneal macrophages of guinea pigs at concentrations of 10-6-5×10-5M, and its potency (IC50=5.7×10-6M) was approximately equivalent to that of SBTI while much weaker than that of SOD (IC50=5.7×10-9M). Lysozyme and egg albumin as reference proteins lacked the SOD-like activity. The anti-edema activity of PR-B given intravenously was stronger than that of SBTI and SOD in the carrageenininduced hind paw edema test in rats. These results were discussed in connection with the mode of anti-inflammatory action of PR-B.
Hepatocellular carcinoma associated with a rare combination of polycythemia and chronic thyroiditis. (1988)

A case of hepatocellular carcinoma associated with polycythemia and chronic thyroiditis, is reported in a 76-year-old female. At autopsy, the liver tumor was shown to be co-existent with liver cirrhosis. A series of hematological studies including the determination of plasma erythropoietin levels, led to the conclusion that this patient's polycythemia was most likely due to an excessive production of erythropoietin by the liver tumor. Chronic thyroiditis, another combined disease, might be related to liver cirrhosis, if the formerly advocated "hepato-thyroidal syndrome" is accepted. The author reports on this patient, since prior to this case there has been no documented case report of hepatocellular carcinoma accompanying both polycythemia and chronic thyroiditis.
Comparative Ultrastructural Features of Secreting and Nonsecreting Glandular Trichomes of Two Genotypes of Nicotiana tabacum L. (1991)

A genotypic difference in Nicotiana tabacum L. for the secreting capability of glandular trichomes was used to determine if the secretory function had an ultrastructural basis. Ultrastructural features of young expanding leaves of two genotypes that differ in the secreting capability of their glandular trichomes were determined. The secreting glandular trichomes of T.I. 1068 and the nonsecreting glandular trichomes of T.I. 1406 had multicellular stalks and six- to eight-celled heads. The secreting type had well-developed chloroplasts and other cytoplasmic organelles, but no secretory pathway was evident. Nonsecreting trichomes lacked chloroplasts but did have unusual inclusions in the cytoplasm. These inclusions, which were either membrane-bound or free in the cytoplasm, appeared to develop from the aggregation of membranous material. We hypothesize that the gene responsible for the lack of secreting capability interrupted normal chloroplast development and that chloroplasts in N. tabacum trichomes are necessary for the synthesis of certain exudate compounds.
Extent of Pyrolysis Impacts on Fast Pyrolysis Biochar Properties (2012)

A potential concern about the use of fast pyrolysis rather than slow pyrolysis biochars as soil amendments is that they may contain high levels of bioavailable C due to short particle residence times in the reactors, which could reduce the stability of biochar C and cause nutrient immobilization in soils. To investigate this concern, three corn ( L.) stover fast pyrolysis biochars prepared using different reactor conditions were chemically and physically characterized to determine their extent of pyrolysis. These biochars were also incubated in soil to assess their impact on soil CO emissions, nutrient availability, microorganism population growth, and water retention capacity. Elemental analysis and quantitative solid-state C nuclear magnetic resonance spectroscopy showed variation in O functional groups (associated primarily with carbohydrates) and aromatic C, which could be used to define extent of pyrolysis. A 24-wk incubation performed using a sandy soil amended with 0.5 wt% of corn stover biochar showed a small but significant decrease in soil CO emissions and a decrease in the bacteria:fungi ratios with extent of pyrolysis. Relative to the control soil, biochar-amended soils had small increases in CO emissions and extractable nutrients, but similar microorganism populations, extractable NO levels, and water retention capacities. Corn stover amendments, by contrast, significantly increased soil CO emissions and microbial populations, and reduced extractable NO. These results indicate that C in fast pyrolysis biochar is stable in soil environments and will not appreciably contribute to nutrient immobilization.
Barriers to Glucose Control in the Intensive Care Unit (2006)

Despite published evidence supporting glycemic control in critically ill patients, achieving euglycemia remains a problem in the intensive care units (ICUs) of many institutions. Clinicians seeking to implement the findings of published evidence in their practice face many potential barriers that make euglycemia difficult to achieve in patients in the ICU. Developing a comprehensive understanding of the many barriers to ICU glucose control can aide clinicians in attempting to change practice and improve patient outcomes. Barriers to ICU glucose control include the role of different health professionals in glucose management, communication among health care professionals, guidelines, protocols, ICU culture, fear of hypoglycemia, glucose monitoring, education, systems analysis, health care resources, nutritional needs, and drug utilization. By ensuring compliance, changing ICU culture, developing guidelines and protocols, and incorporating a multidisciplinary approach, clinicians can achieve glycemic control in the critically ill population and improve patient outcomes.