gebhart/patrepeval huggingface dataset:
Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5–Dependent Expression of Bcl-XL (2000)

Bcr-Abl-expressing leukemic cells are highly resistant to apoptosis induced by chemotherapeutic drugs. Although a number of signaling molecules have been shown to be activated by the Bcr-Abl kinase, the antiapoptotic pathway triggered by this oncogene has not been elucidated. Here, we show that the interleukin 3-independent expression of the antiapoptotic protein, Bcl-xL, is induced by Bcr-Abl through activation of signal transducer and activator of transcription (Stat)5. Inhibition of the Bcr-Abl kinase activity in Bcr-Abl-expressing cell lines and CD34(+) cells from chronic myelogenous leukemia (CML) patients induces apoptosis by suppressing the capacity of Stat5 to interact with the bcl-x promoter. Interestingly, after inhibition of the Bcr-Abl kinase, the expression of Bcl-xL is downregulated more rapidly in chronic phase than in blast crisis CML cells, suggesting an involvement of this protein in disease progression. Overall, we describe a novel antiapoptotic pathway triggered by Bcr-Abl that may contribute to the resistance of CML cells to undergo apoptosis.
A Virtual Ecosystem (2005)

Just as e-business began as a specialized and separate operating and delivery model in companies and has since become a standard way of doing business, virtual teams, organizations, and business models will be the way that things are done. Once we reach a fully virtual business ecosystem, we see two major roles emerging: (1) highly specialized, efficient, and optimized content providers, and (2) customer focused, value-added integrators.
Chiral Ammonium Betaines as Ionic Nucleophilic Catalysts (2010)

Catalyst debut: The chiral ammonium betaine 1 has been successfully applied to the asymmetric Steglich rearrangement as an ionic nucleophilic catalyst. The catalyzed reaction results in record levels of product enantioselectivity, and has a broad substrate scope. M.S.=molecular sieves, Troc=2,2,2-trichloroethoxycarbonyl.
Observational study of surface ozone at New Delhi, India (2005)

Surface ozone has been measured over New Delhi, an urban site, a region of intensive anthropogenic activity since 1997. Seasonal variations in ozone concentration show pronounced maxima in the summer and autumn seasons and minima in monsoon and winter seasons. Diurnal patterns in ozone concentration show daytime in situ photochemical production throughout the year. The high ozone episode days were associated with meteorological parameters such as sunny and warm weather, stagnant wind patterns and low relative humidity. The monthly average maximum concentration in summer was found to be in the range of 62–95 ppb whereas, it was found to be 50–82 ppb in the autumn (October and November). The analysis of hourly averaged surface ozone data illustrates that on a large number of days the surface ozone values at Delhi exceed the World Health Organization (WHO) ambient air quality standards (hourly average of 80 ppb) for ozone. On some occasions, night‐time increases of surface ozone concentration have been observed under stable boundary layer conditions and during thunderstorms.
Rapid Laser Forming of Titanium Near Shape Articles: LaserCast (2018)

An ongoing collaborative program sponsored by the DoD Advanced Research Projects\nAgency (DARPA) and the Office ofNaval Research (ONR) continues to show promising results in\nthe development of a new laser based manufacturing process. The program's goals are to develop\nand demonstrate a laser based, rapid manufacturing system (LaserCastTM) for titanium and its\nalloys. Economical precursor powders are being laser formed into integral, 100% dense, nearshape\narticles by sequentially fusing multiple metal-powder layers in a controlled environment.\nA CO2 continuous wave (CW) high energy laser has been used to form commercially pure (CP)\ntitanium, Ti-6AI-4V, and Ti-5AI-2.5Sn in varied geometries from I-inch square bars to a 4-inch\ndiameter (I-inch wall ) cylinder. Materials characterization tests, revealing excellent chemistry\ncontrol and mechanical properties, are presented. Large near-shape structures may be formed\ndirectly from metal powders, without using molds or dies, by direct download and postprocessing\nfrom a Computer Aided Design (CAD) database. Economic projections indicate\nsignificant reductions in manufacturing costs and "time to market" production cycles when the\nLaserCast process is used instead of conventional casting and forging processes.
Combined carrier status of prothrombin 20210A and factor XIII-A Leu34 alleles as a strong risk factor for myocardial infarction: evidence of a gene-gene interaction (2003)

Studies associating the prothrombin 20210G>A (FII 20210A), factor V Leiden (FVL), and factor XIII Leu34 (FXIII-A Leu34) alleles with myocardial infarction (MI) have yielded conflicting results. Complicated gene-gene interactions, small sample sizes, and heterogeneous genetic and environmental backgrounds may contribute to opposing findings. Simultaneous analysis of multiple gene variants in a large sample size from a genetically isolated population may overcome these weaknesses. Genotyping was performed in 500 MI patients and 500 control subjects from the genetically isolated Newfoundland population to determine the prevalence of the FII 20210A, FVL, and FXIII-A Leu34 variants and their association with MI. Gene-gene interactions were also analyzed. The prevalence of the FII 20210A allele was higher in MI patients (3.2%) than in control subjects (1.0%; P =.015). The FII 20210A allele was also 5.6-fold higher in MI patients younger than 51 years than in age-matched control subjects (P =.04). FVL showed 3.9-fold higher prevalence in young patients than in patients older than 50 years (P =.004) and 2.7-fold higher than in age-matched control subjects (P =.007). Furthermore, the prevalence of combined carriers of the FXIII-A L34 and FII 20210A alleles was 12-fold higher in MI patients than in control subjects (P =.002) and with 92% penetrance. There was disequilibrium of the FXIII-A Leu34 allele to MI patients carrying the FII 20210A allele as a genetic background. Based on our data, we determined that (1) the FII 20210A allele is a risk factor for MI, possibly important for early onset; (2) FVL may predispose for early-onset MI; (3) the FXIII-A Leu34 allele predisposes for MI in males only; however, (4) interaction between the FII 20210A and FXIII-A Leu34 alleles forms a synergistic coeffect that strongly predisposes for MI, placing combined carriers at high risk for MI.
[Detection methods and occurrence of Cryptosporidium sp. in selected surface waters]. (1991)

Cryptosporidium, a small coccidian parasite, is accepted as an important cause of severe diarrheal illness in man and animals; in immunocompromised persons illness may be life-threatening. Cryptosporidium is transmitted by oocysts, passed in the faeces. These oocysts are remarkable resistant to common disinfectants and they can survive for several months. Person-to-person, animal-to-person and faecal contaminations of the environment are proven routes of transmission. Also waterborne disease outbreaks caused by Cryptosporidium are well documented. This paper represents a modification of a method for the detection of Cryptosporidium in water, developed by Musial et al. and Rose et al. The method includes steps for filtration, elution, centrifugation, flotation and microscopic detection of Cryptosporidium oocysts in sediments using an indirect immunofluorescence technique and a native contrast-technique. With this modified method efficiency of recovery ranged from 8.1% to 27.1%. In addition, selected surface waters in Northrhine-Westphalia were examined. The finding of Cryptosporidium oocysts in 7 of 9 water samples (78%) demonstrates the occurrence of Cryptosporidium oocysts in surface waters in Western-Germany. These results suggest that more detailed studies are needed to assess the risk of this new pathogen in water, especially in removal and disinfection in water treatment plants.
An analog adaptive feedforward amplifier linearizer (2004)

Feedforward is a wideband linearization method capable for third generation mobile communication systems. However, it requires automatic adaptation of key parameters for reliable distortion cancellation as operating conditions vary. This paper presents a novel time-continuous adaptive compensation technique for the amplitude and phase imbalances of feedforward amplifiers. In contrast to algorithm-based digital techniques, the proposed method can be implemented entirely with analog circuitry and, consequently, enables a fully integrated low-cost analog adaptive feedforward linearizer. The functionality of the proposed analog adaptive feedforward amplifier is verified by means of simulations. Results for a WCDMA signal demonstrate that the adaptation is sufficiently fast and accurate with the out-of-hand power being suppressed to below -50 dBc.
Asymptotically optimum radar detection in compound-Gaussian clutter (1995)

An asymptotically optimum receiver designed for detecting coherent pulse trains in compound-Gaussian clutter is introduced and assessed. The proposed receiver assumes knowledge of the structure of the clutter covariance matrix, but does not require that of its amplitude probability density function (apdf). Performance is analytically evaluated, showing that the loss, as measured with respect to the corresponding optimum structure, is kept within a few dBs even for a relatively small number of integrated pulses and that it largely outperforms the matched-filter detector under all instances of practical interest. Interestingly, the proposed detector achieves constant false alarm rate (CFAR), regardless of the clutter envelope distribution and, consequently, its power.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Dynamic Performance Testing of Single-Element Unbalanced Gas-Lift Valves (1987)

Summary Reliable predictions of injection gas passage through gas-lift valves are important for unloading and lifting high-capacity wells. This paper outlines the procedure for conducting static and dynamic tests required to evaluate gas-lift valve performance. Limited test results are presented for the 1- and 1½in. [25.4-and 38.1-mm] unbalanced bellows-charged gas-lift valves with three-ply monel bellows.
Highly Efficient Low-Level Feature Extraction For Video Representation And Retrieval (2004)

Witnessing the omnipresence of ever complex yet so intuitive digital video media, research community has raised the question of its meaningful use and management. Stored in immense multimedia databases, digital videos need to be retrieved and structured in an intelligent way, relying on the content and the rich semantics involved. Therefore, the third generation of Content Based Video Indexing and Retrieval systems faces the problem of the semantic gap between the simplicity of the available visual features and the richness of user semantics. This work focuses on the issues of efficiency and scalability in video indexing and retrieval to facilitate a video representation model capable of semantic annotation. A highly efficient algorithm for temporal analysis and key-frame extraction is developed. It is based on the prediction information extracted directly from the compressed-domain features and the robust scalable analysis in the temporal domain. Furthermore, a hierarchical quantisation of the colour features in the descriptor space is presented. Derived from the extracted set of low-level features, a video representation model that enables semantic annotation and contextual genre classification is designed. Results demonstrate the efficiency and robustness of the temporal analysis algorithm that runs in real time maintaining the high precision and recall of the detection task. Adaptive key-frame extraction and summarisation achieve a good overview of the visual content, while the colour quantisation algorithm efficiently creates hierarchical set of descriptors driven by the perceptual image degradation. Finally, the video representation model, supported by the genre classification algorithm, achieves excellent results in an automatic annotation system by linking the video clips with a limited lexicon of related keywords.
Cloning and Characterization of a Novel Membrane-associated Lymphocyte NAD:Arginine ADP-ribosyltransferase (1996)

Mono-ADP-ribosylation is a post-translational modification of proteins in which the ADP-ribose moiety of NAD is transferred to proteins and is responsible for the toxicity of some bacterial toxins (e.g. cholera toxin and pertussis toxin). NAD:arginine ADP-ribosyltransferases cloned from human and rabbit skeletal muscle and from mouse lymphoma (Yac-1) cells are glycosylphosphatidylinositol-anchored and have similar enzymatic and physical properties; transferases cloned from chicken heterophils and red cells have signal peptides and may be secreted. We report here the cloning and characterization of an ADP-ribosyltransferase (Yac-2), also from Yac-1 lymphoma cells, that differs in properties from the previously identified eukaryotic transferases. The nucleotide and deduced amino acid sequences of the Yac-1 and Yac-2 transferases are 58 and 33% identical, respectively. The Yac-2 protein is membrane-bound but, unlike the Yac-1 enzyme, appears not to be glycosylphosphatidylinositol-anchored. The Yac-1 and Yac-2 enzymes, expressed as glutathione S-transferase fusion proteins in Escherichia coli, were used to compare their ADP-ribosyltransferase and NAD glycohydrolase activities. Using agmatine as the ADP-ribose acceptor, the Yac-1 enzyme was predominantly an ADP-ribosyltransferase, whereas the transferase and NAD glycohydrolase activities of the recombinant Yac-2 protein were equivalent. The deduced amino acid sequence of the Yac-2 transferase contained consensus regions common to several bacterial toxin and mammalian transferases and NAD glycohydrolases, consistent with the hypothesis that there is a common mechanism of NAD binding and catalysis among ADP-ribosyltransferases.
Seed Size Effects Upon Seedling Vigor of Three Forage Legumes<sup>1</sup> (1972)

Seed size‐seedling vigor relationships were studied with birdsfoot trefoil ( Lotus corniculatus L.), alfalfa ( Medicago sativa L.), and sainfoin ( Onobrychis viciaefolia Scop.). Differences in seed size were separated into those among plants and within plants. Seed weight distribution patterns were measured for each plant. An additional study measured the effect of varying number of seeds per raceme upon seed size of sainfoin. Correlations among clones of seed size with seedling vigor were significant in birdsfoot trefoil, were not significant in alfalfa, and approached a significant level in sainfoin. Differences in seed size within plants were highly correlated with seedling vigor in all legume species. The degree to which seed size can be affected by regulating seed number per raceme was shown for five sainfoin plants. Seed weight distribution patterns varied widely among plants within a species. The importance of these patterns in selecting for seedling vigor and in obtaining genetic equality in the contribution of plants to a composite variety is discussed.
NTIRE 2017 Challenge on Single Image Super-Resolution: Methods and Results (2017)

This paper reviews the first challenge on single image super-resolution (restoration of rich details in an low resolution image) with focus on proposed solutions and results. A new DIVerse 2K resolution image dataset (DIV2K) was employed. The challenge had 6 competitions divided into 2 tracks with 3 magnification factors each. Track 1 employed the standard bicubic downscaling setup, while Track 2 had unknown downscaling operators (blur kernel and decimation) but learnable through low and high res train images. Each competition had ∽100 registered participants and 20 teams competed in the final testing phase. They gauge the state-of-the-art in single image super-resolution.
Rule-based service composition and service-oriented business rule management (2008)

As business processes change constantly, there is a growing need for adaptive composite services. Unfortunately, existing service composition languages and techniques result in rather brittle and rigid processes, whose services live in a straitjacket. In this paper, we propose a rule-driven approach for service composition that is purely declarative, highly adaptive and integrated in a truly service-oriented approach to business rule management.
Microwave-Induced Esterification Using Heterogeneous Acid Catalyst in a Low Dielectric Constant Medium (2000)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTMicrowave-Induced Esterification Using Heterogeneous Acid Catalyst in a Low Dielectric Constant MediumKonrad G. Kabza, Brian R. Chapados, Jason E. Gestwicki, and Jessica L. McGrathView Author Information Department of Chemistry, State University of New York College at Fredonia, Fredonia, New York 14063 Cite this: J. Org. Chem. 2000, 65, 4, 1210–1214Publication Date (Web):February 3, 2000Publication History Received23 March 1999Published online3 February 2000Published inissue 1 February 2000https://pubs.acs.org/doi/10.1021/jo990515chttps://doi.org/10.1021/jo990515cbrief-reportACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1352Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Electromagnetic radiation,Organic polymers,Organic reactions,Radiation,Reaction rates Get e-Alerts
DBTG: Demand-Driven Backtracking Test Generation (2008)

Test generation techniques are still weak, especially to large or complex programs. This paper presents a new test generation method, which can automatically generate inputs triggering bugs with greatly mitigating the path explosion problem. The method performs intraprocedural analysis to find potential bugs using a combined symbolic and concrete execution with simplifying callee functions; then backtracks from the bug statement to program entry to find interprocedural paths with pruning infeasible paths in due course; finally expands callee functions of these paths to prune infeasible paths again. Demand-driven means that as few paths as possible are explored in order to find feasible paths triggering bugs. We have implemented a tool based on Phoenix framework and Z3 solver. To the best of our knowledge, it is the first security analysis tool working on intermediate representation between source and binary using a combined symbolic and concrete execution. Preliminary experiments on real code of nbsmtp SMTP client are promising.
Toxic and DNA‐damaging activities of the fungicides mancozeb and thiram (TMTD) on human lymphocytes in vitro (1989)

The cytotoxic and mutagenic effects of the fungicides mancozeb and thiram were studied using human peripheral blood lymphocytes cultured in vitro with or without an S-9 mix microsomal metabolizing system. The results obtained suggested that the chemicals caused dose-dependent inhibition of thymidine uptake and unscheduled DNA synthesis on both resting and proliferating lymphocytes in the absence of the S-9 mix. In the presence of the S-9 mix, only thiram showed mutagenic activity by eliciting unscheduled DNA synthesis and a significantly higher frequency of sister chromatid exchanges than did controls.
Measurement of aliasing distortions and quantization noise in multirate systems (2003)

A method to measure linear and nonlinear distortions in implemented digital multirate systems is presented. The system to be measured is modeled as a parallel connection of a linear system, described by its bifrequency system function, and a nonlinear system producing the observed deviations from linearity. The output signal of the latter system, being cyclostationary in general, is described by a bifrequency spectral density, a generalization of the power spectral density. The bifrequency system function includes both the linear time-invariant transfer function of the system and further transmissions from the input to the output which result from aliasing and/or imaging distortions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8<sup>+</sup>T cells (2012)

Successful cancer immunotherapy is thought to require de novo priming of tumor specific CD8(+) T cells in lymphatic organs. Contrasting these beliefs, cancer therapy based on interleukin-10 (IL-10) results in tumor rejection without a requirement for T-cell trafficking from lymphatic organs. Rather, IL-10 directly activates autochthonous, tumor-resident CD8(+) T cells.
The Basis of the Kalvar System of Photography<sup>*</sup> (1962)

In the Kalvar process image formation is accomplished by light scattering rather than by light absorption. A compound which will undergo photolysis to yield volatile products is dispersed in a polymeric vehicle which can be relaxed by heat. Upon exposure to light,internal pressures are produced within the vehicle resulting in a “latent image” of internal stresses. Upon subsequent exposure to heat, reorientation and an ordered recrystallization of the polymer result from the force of these internal pressures. Thereoriented and recrystallized portions of the polymer scatter light strongly to produce the developed photographic image.
Inverse problem solver for multiple light scattering using modified Born series (2022)

The inverse scattering problem, whose goal is to reconstruct an unknown scattering object from its scattered wave, is essential in fundamental wave physics and its wide applications in imaging sciences. However, it remains challenging to invert multiple scattering accurately and efficiently. Here, we exploit the modified Born series to demonstrate an inverse problem solver that efficiently and directly computes inverse multiple scattering without making any assumptions. The inversion process is based on a physically intuitive approach and can be easily extended to other exact forward solvers. We utilize the proposed method in optical diffraction tomography and numerically and experimentally demonstrate 3D reconstruction of optically thick specimens with higher fidelity than those obtained using conventional methods based on the weak scattering approximation.