gebhart/patrepeval huggingface dataset:
Albumin Microspheres II: Applications in Drug Delivery (1989)

Albumin microspheres are colloidal particles which are known to sustain the release of entrapped therapeutic agent(s). The rate at which these particles metabolise in vivo can be manoeuvred by varying their synthetic conditions. These particles alter the in vivo distribution of included drugs and hence this carrier has been extensively investigated for drug delivery and targeting in laboratory animals. Attempts have also been made to use this carrier for the delivery of anti-cancer agents in patients with liver cancer. This review is focused on the experimental and clinical applications of albumin microspheres in drug delivery. An account of the toxicological properties of these particles is also presented.
Influence of pressure on the equilibrium of hydration of aliphatic aldehydes (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of pressure on the equilibrium of hydration of aliphatic aldehydesCharles A. Lewis and Richard. WolfendenCite this: J. Am. Chem. Soc. 1973, 95, 20, 6685–6688Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/ja00801a026https://doi.org/10.1021/ja00801a026research-articleACS PublicationsRequest reuse permissionsArticle Views371Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Losing functions without gaining data (2009)

We describe a transformation which takes a higher-order program, and produces an equivalent first-order program. Unlike Reynolds-style defunctionalisation, it does not introduce any new data types, and the results are more amenable to subsequent analysis operations. We can use our method to improve the results of existing analysis operations, including strictness analysis, pattern-match safety and termination checking. Our transformation is implemented, and works on a Core language to which Haskell programs can be reduced. Our method cannot always succeed in removing all functional values, but in practice is remarkably successful.
Speaker diarization using PLDA-based speaker clustering (2011)

This paper investigates application of the Probabilistic Linear Discriminant Analysis (PLDA) for speaker clustering within a speaker diarization framework. Factor analysis is employed to extract low-dimensional representation of a sequence of acoustic feature vectors - so called i-vectors - and these i-vectors are modeled using the PLDA. Experiments were carried out using the COST278 broadcast news database. We achieved 33.7% relative improvement of the Diarization Error Rate (DER) and 43.8% relative improvement of the speaker error rate compared to the baseline system using clustering based on the Bayesian Information Criterion (BIC).
Position Estimation of Access Points in 802.11 Wireless Networks (2003)

We developed a technique to locate wireless network nodes using multiple time-of-flight range measurements in a position estimate. When used with communication methods that allow propagation through walls, such as Ultra-Wideband and 802.11, we can locate network nodes in buildings and in caves where GPS is unavailable. This paper details the implementation on an 802.11a network where we demonstrated the ability to locate a network access point to within 20 feet.
Minimal-Size, Constrained Corticotropin-Releasing Factor Agonists with<i>i</i>−(<i>i</i>+3) Glu−Lys and Lys−Glu Bridges (1998)

In three earlier publications (Miranda et al. J. Med. Chem. 1994, 37, 1450-1459; 1997, 40, 3651-3658; Gulyas et al. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 10575-10579) we have hypothesized that covalent constraints such as side-chain-to-side-chain lactam rings would stabilize an alpha-helical conformation shown to be important for the recognition and binding of the CRF C-terminus 30 residues, to CRF receptors. These studies led to the discovery of useful CRF antagonists such as alpha-helical CRF (alpha-hel-CRF) and Astressin both in vitro and in vivo. To test the hypothesis that such lactam rings may also be modulating activation of the receptor when introduced at the N-terminus of CRF, we studied the influence of the successive introduction from residues 4 to 14 of a cyclo(i, i+3)[Lysi-Glu(i+3)] and a cyclo(i,i+3)[Glui-Lys(i+3)] bridge on the in vitro potency of the agonist [Ac-Pro4,dPhe12,Nle21,38]hCRF(4-41) and related compounds. We have also introduced the favored cyclo(Glu30-Lys33) substitution found to be remarkable in several families of antagonists (such as Astressin) and in a number of CRF agonists and investigated the role of residues 4-8 on receptor activation using successive deletions. Earlier studies had shown that in both oCRF and alpha-helical CRF, deletion of residues 1-6, 1-7, and 1-8 led to gradual loss of intrinsic activity (IA) (from 50% IA to <10% IA) resulting in alpha-hel-CRF being a potent competitive antagonist. We show that acetylation of the N-terminus of these fragments generally increases potency by a factor of 2-3 with no influence on IA. While cyclo(30-33)[Ac-Leu8,dPhe12,Nle21, Glu30,Lys33,Nle38]hCRF(8-41) (30) is the shortest reported analogue of CRF to be equipotent to CRF (70% IA), the corresponding linear analogue (31) is 120 times less potent (59% IA). Addition of one amino acid at the N-terminus ¿cyclo(30-33)[Ac-Ser7,dPhe12,Nle21, Glu30,Lys33,Nle38]hCRF(7-41) (28)¿ results in a 5-fold increase in agonist potency and full intrinsic activity (113%). The most favored modifications were also introduced in other members of the CRF family including sauvagine (Sau), urotensin (Utn), urocortin (Ucn), and alpha-hel-CRF. Parallel and consistent results were obtained suggesting that the lactam cyclization at residues 29-32 and 30-33 (for the members of the CRF family with 40 and 41 amino acid residues, respectively) will induce (in the shortened agonists) a structural constraint (alpha-helix) that stabilizes a bioactive conformation similar to that shown in the Astressin family of CRF antagonists and that residue 8 (leucine or isoleucine) bears the sole responsibility for activation of the receptor since deletion of that residue leads to potent antagonists (Gulyas et al. Proc. Natl. Acad.Sci. U.S.A. 1995, 92, 10575-10579).
Secondary relaxation motion in bisphenol A polycarbonate (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSecondary relaxation motion in bisphenol A polycarbonateJae Y. Jho and Albert F. YeeCite this: Macromolecules 1991, 24, 8, 1905–1913Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://doi.org/10.1021/ma00008a031Request reuse permissionsArticle Views620Altmetric-Citations96LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alertsclose Get e-Alerts
기업내 e-learning의 반응, 학습성과 및 전이성과간 관계: 교육참가자의 개인특성 및 조직환경의 조절효과를 중심으로 (2004)

This study explores the relationship between reaction/learning performance and transfer performance, and analyzes the moderating effect of organizational characteristics on training effectiveness in e-learning settings. Based on the previous literature conducted on the traditional training environme...
Créer des cerveaux grâce à la recherche opérationnelle ? (2018)

Résumé de présentation du projet en cours 2017-2018
An Unnatural Hydrophobic Base Pair with Shape Complementarity between Pyrrole-2-carbaldehyde and 9-Methylimidazo[(4,5)-b]pyridine (2003)

An unnatural hydrophobic base, pyrrole-2-carbaldehyde (denoted as Pa), was developed as a specific pairing partner of 9-methylimidazo[(4,5)-b]pyridine (Q). The Q base is known to pair with 2,4-difluorotoluene (F) as an isostere of the A-T pair, and F also pairs with A efficiently in replication. In contrast, the Q-Pa pair showed specific selectivity in replication, and the five-membered-ring base Pa paired efficiently with Q but paired poorly with A. In addition, the interaction of Pa with DNA polymerases was superior, in comparison to that of F. The aldehyde group of Pa was recognized well by the Klenow fragment of Escherichia coli DNA polymerase I and the reverse transcriptase of Avian myeloblastosis virus. The structural features of the Q-Pa pair in a DNA duplex were analyzed by NMR, showing the shape complementarity of the Pa fitting with Q. The structurally unique base Pa provides valuable information for the development of unnatural base pairs toward the expansion of the genetic alphabet.
Syntactic simplification for improving content selection in multi-document summarization (2004)

In this paper, we explore the use of automatic syntactic simplification for improving content selection in multi-document summarization. In particular, we show how simplifying parentheticals by removing relative clauses and appositives results in improved sentence clustering, by forcing clustering based on central rather than background information. We argue that the inclusion of parenthetical information in a summary is a reference-generation task rather than a content-selection one, and implement a baseline reference rewriting module. We perform our evaluations on the test sets from the 2003 and 2004 Document Understanding Conference and report that simplifying parentheticals results in significant improvement on the automated evaluation metric Rouge.
Carbanions. III. Cleavage of Tetraalkylammonium Halides by Sodium in Liquid Ammonia<sup>1</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbanions. III. Cleavage of Tetraalkylammonium Halides by Sodium in Liquid Ammonia1Erling Grovenstein Jr. and Robert W. StevensonCite this: J. Am. Chem. Soc. 1959, 81, 18, 4850–4857Publication Date (Print):September 1, 1959Publication History Published online1 May 2002Published inissue 1 September 1959https://pubs.acs.org/doi/10.1021/ja01527a024https://doi.org/10.1021/ja01527a024research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-resolution optical measurement of fiber optics transmission line length (2009)

This paper studies a frame-loss-free shunt system for broadband optical fiber transmission lines. This system switches transmitting optical pulses between duplicated optical fibers to avoid any interruption to communication. A high-resolution measurement technique is necessary to evaluate the optical fiber length. We applied an interferometry technique to adjust 15 km duplicated optical lines at a resolution of 10 mm. An optical line switching system and procedure are designed for use in replacing in-service optical lines. A free space optics (FSO) system adjusts the length of an in-service optical line by up to 100 m. A gigabit ether-passive optical network (GE-PON) line is successfully replaced with an extended line while maintaining transmission.
Characterization of the methanotrophic bacterial community present in a trichloroethylene-contaminated subsurface groundwater site (1993)

Groundwater, contaminated with trichloroethylene (TCE) and tetrachloroethylene (PCE), was collected from 13 monitoring wells at Area M on the U.S. Department of Energy Savannah River Site near Aiken, S.C. Filtered groundwater samples were enriched with methane, leading to the isolation of 25 methanotrophic isolates. The phospholipid fatty acid profiles of all the isolates were dominated by 18:1 omega 8c (60 to 80%), a signature lipid for group II methanotrophs. Subsequent phenotypic testing showed that most of the strains were members of the genus Methylosinus and one isolate was a member of the genus Methylocystis. Most of the methanotroph isolates exhibited soluble methane monooxygenase (sMMO) activity. This was presumptively indicated by the naphthalene oxidation assay and confirmed by hybridization with a gene probe encoding the mmoB gene and by cell extract assays. TCE was degraded at various rates by most of the sMMO-producing isolates, whereas PCE was not degraded. Savannah River Area M and other groundwaters, pristine and polluted, were found to support sMMO activity when supplemented with nutrients and then inoculated with Methylosinus trichosporium OB3b. The maximal sMMO-specific activity obtained in the various groundwaters ranged from 41 to 67% compared with maximal rates obtained in copper-free nitrate mineral salts media. This study partially supports the hypothesis that stimulation of indigenous methanotrophic communities can be efficacious for removal of chlorinated aliphatic hydrocarbons from subsurface sites and that the removal can be mediated by sMMO.
Sintering of a Mixed Phase Y-Ba-Cu-O in a Pulsed Electric Field (1987)

We treated the samples of a mixed phase of nominal composition Y1.2Ba0.8CuO4 in a pulsed electric field (PEF) during the course of sintering. The field was effective in the temperature range (20 ÷ 500) °C and the superconducting (SC) properties reveal an enhancement the of SC transition temperature (Tc). Temperature dependence of the resistance above Tc obeys ∼ exp [Q/T]1/4 law. The enhancement of Tc was correlated to Q, a localization parameter inversely proportional to the density of states on the Fermi surface.
[Comparative study on the expression and interaction of oncogene c-fos/c-jun and three opioid genes induced by low and high frequency electroacupuncture]. (1996)

The present work was designed (a) to study comparatively the effect of 2Hz and 100Hz electroacupuncture (EA) on the expression of oncogene c-fos/c-jun and three opioid (preproenkephalin-PPE; preprodynorphin-PPD; proopiomelanocortin-POMC) genes in the rat brain; (b) to clarify the role of Fos/Jun (AP-1) on opioid genes expression induced by EA stimulation through specific blockade of EA-induced Fos/Jun expression using antisense oligodeoxynucleotides (ODNs) of c-fos/c-jun. The results were: (a) 2Hz and 100Hz EA induced differential Fos expression in different brain areas; (b) EA of both frequencies accelerated PPE gene transcription, but 2Hz EA was more effective than 100Hz EA; (c) PPD expression was accelerated by 100Hz EA, but not by 2Hz EA; (d) the blockade of Fos/Jun expression by c-fos/c-jun antisense ODNs prevented EA from accelerating PPD but not PPE mRNA expression.
Polyphosphoinositides and the shape of mammalian erythrocytes (1985)

Abstract The relationship between polyphosphoinositide and phosphatidic acid (PA) metabolism and Mg‐ATP dependent shape and viscosity changes in erythrocyte ghosts from four mammalian species was examined. Ghosts prepared from rabbit, dog, human and guinea pig erythrocytes were transformed from echinocytes to discocytes within 15 min in the presence of 1 mM Mg‐ATP at 25 C. In all species these Mg‐ATP shape transformations were associated with a 30–45% decrease in the specific viscosity of the ghost suspensions. Mg‐ATP induced a second transformation of discocytic ghosts to cup shape forms without a further decrease in viscosity. A considerable species variation in the rates of Mg‐ATP dependent viscosity and shape changes and incorporation of 32 P into phosphatidylinositol‐4′ phosphate (PIP), phosphatidylinositol‐4′5′bisphosphate (PIP 2 ) and especially PA form MG‐[ γ 32 P]‐ATP in ghosts was found. However, the rates of Mg‐ATP dependent synthesis of PIP and PIP 2 and shape and viscosity changes in each species were of the same magnitude. Ca 2+ or neomycin strongly inhibited PIP labeling and Mg‐ATP shape and viscosity changes in ghosts of the different species. Ca 2+ or neomycin usually increased or had little effect on 32 P incorporation into PA and PIP 2 . The possibility that Mg‐ATP‐induced changes in erythrocyte membrane shape and deformability are dependent on increases in membrane PIP and PIP 2 is discussed.
A Straightforward Synthesis of N-Substituted Ureas from Primary Amides (2020)

A direct and convenient method for the preparation of N-substituted ureas is achieved by treating primary amides with phenyliodine diacetate (PIDA) in the presence of an ammonia source (NH3 or ammonium carbamate) in MeOH. The use of 2,2,2-trifluoroethanol (TFE) as the solvent increases the electrophilicity of the hypervalent iodine species and allows the synthesis of electron-poor carboxamides. This transformation involves a nucleophilic addition of ammonia on the isocyanate intermediate generated in situ by a Hofmann rearrangement of the starting amide.
Economic and Synergistic Pedestrian Tracking System for Indoor Environments (2009)

We describe an indoor pedestrian tracking system that can economically improve the tracking performance and the quality and value of services by incorporating other services synergistically. Our tracking system utilizes existing infrastructures to be used for security services such as surveillance cameras and active RFID tags which are sparsely put in place and generally used in plants, offices, and commercial facilities for estimating user's walking parameters and correction of tracking errors without significantly increasing costs, and realizes the improvement of the tracking performance by them. Furthermore, by sharing not only surveillance videos and RFID signals from security services but also the tracking information and models from 3D environment modeling services among services, each service can enhance the quality and value of the service and relatively reduce the costs for creating the data and realizing functions.
Discovery of 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1<i>H</i>-1,2,4-triazole, a Novel in Vivo Cannabinoid Antagonist Containing a 1,2,4-Triazole Motif (2004)

A new series of 1,2,4-triazoles have been prepared and the evaluation of their cannabinoid properties have been carried out. Compound 8 showed cannabinoid silent antagonist activity in mouse vas deferens and guinea pig ileum preparations and in vivo assays (cannabinoid tetrad) in mouse. It did not have intrinsic activity in these bioassays, and therefore, it did not behave as a partial agonist or an inverse agonist.
Scalable multi-dimensional user intent identification using tree structured distributions (2011)

The problem of identifying user intent has received considerable attention in recent years, particularly in the context of improving the search experience via query contextualization. Intent can be characterized by multiple dimensions, which are often not observed from query words alone. Accurate identification of Intent from query words remains a challenging problem primarily because it is extremely difficult to discover these dimensions. The problem is often significantly compounded due to lack of representative training sample. We present a generic, extensible framework for learning the multi-dimensional representation of user intent from the query words. The approach models the latent relationships between facets using tree structured distribution which leads to an efficient and convergent algorithm, FastQ, for identifying the multi-faceted intent of users based on just the query words. We also incorporated WordNet to extend the system capabilities to queries which contain words that do not appear in the training data. Empirical results show that FastQ yields accurate identification of intent when compared to a gold standard.
Millimeter-wave bandstop filter with absorptive stopband (2014)

This paper presents a new application of absorptive bandstop filter for absorbing the LO-to-RF leakage of mixer in a Q-band heterodyne receiver. The proposed absorptive bandstop filter (ABSF) is achieved by introducing lossy quarter-wavelength resonator to a conventional narrowband bandstop filter. In order to facilitate the receiver system integration, the proposed ABSF is implemented in commercial GaAs pHEMT process. It is designed with a stopband from 31 to 33 GHz, which is the LO frequency range. The measured stopband rejection is better than 35 dB at the stopband center frequency f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> = 32 GHz. Especially, more than 93.4% of the power within the stopband can be dissipated by the ABSF. In this way, by introducing the proposed ABSF between the image rejection filter and the mixer, the impact of LO-to-RF leakage on the conversion gain of mixer can be minimized.
Software phase-locked loop applied to dynamic voltage restorer (DVR) (2002)

In this paper, the analytical and practical design issues of a software phase-locked loop (SPLL) for DVR are presented. A SPLL model that uses a lag/lead loop controller, is derived in order to analyse the system performance and filtering characteristic by the use of bode diagrams and root-locus methods. In DVR applications, parameters of the design of the SPLL controller are not only dependent on the steady state and dynamic state, but also on practical conditions such as utility unbalance, voltage sag/swell magnitude, voltage harmonics, phase jumps and frequency variations. Therefore, the practical aspect of the SPLL implementation has also been discussed. Experimental results demonstrate its phase tracking capability.