gebhart/patrepeval huggingface dataset:
Recruitment of Ikaros to Pericentromeric Heterochromatin Is Regulated by Phosphorylation (2008)

Ikaros encodes a zinc finger protein that is involved in heritable gene silencing. In hematopoietic cells, Ikaros localizes to pericentromeric heterochromatin (PC-HC) where it recruits its target genes, resulting in their activation or repression via chromatin remodeling. The function of Ikaros is controlled by post-translational modifications. CK2 kinase has been shown to phosphorylate Ikaros at its C terminus, affecting cell cycle progression. Using in vivo labeling of murine thymocytes followed by phosphopeptide mapping, we identified four novel Ikaros phosphorylation sites. Functional analysis of phosphomimetic mutants showed that the phosphorylation of individual amino acids determines the affinity of Ikaros toward probes derived from PC-HC. In vivo experiments demonstrated that targeting of Ikaros to PC-HC is regulated by phosphorylation. The ability of Ikaros to bind the upstream regulatory elements of its known target gene terminal deoxynucleotidyltransferase (TdT) was decreased by phosphorylation of two amino acids. In thymocytes, Ikaros acts as a repressor of the TdT gene. Induction of differentiation of thymocytes with phorbol 12-myristate 13-acetate plus ionomycin results in transcriptional repression of TdT expression. This process has been associated with increased binding of Ikaros to the upstream regulatory element of TdT. Phosphopeptide analysis of in vivo-labeled thymocytes revealed that Ikaros undergoes dephosphorylation during induction of thymocyte differentiation and that dephosphorylation is responsible for increased DNA binding affinity of Ikaros toward the TdT promoter. We propose a model whereby reversible phosphorylation of Ikaros at specific amino acids controls the subcellular localization of Ikaros as well as its ability to regulate TdT expression during thymocyte differentiation.
EPR Imaging at a Few Megahertz Using SQUID Detectors (2010)

An apparatus being developed for electron paramagnetic resonance (EPR) imaging operates in the resonance-frequency range of about 1 to 2 MHz well below the microwave frequencies used in conventional EPR. Until now, in order to obtain sufficient signal-to-noise radios (SNRs) in conventional EPR, it has been necessary to place both detectors and objects to be imaged inside resonant microwave cavities. EPR imaging has much in common with magnetic resonance imaging (MRI), which is described briefly in the immediately preceding article. In EPR imaging as in MRI, one applies a magnetic pulse to make magnetic moments (in this case, of electrons) precess in an applied magnetic field having a known gradient. The magnetic moments precess at a resonance frequency proportional to the strength of the local magnetic field. One detects the decaying resonance-frequency magnetic- field component associated with the precession. Position is encoded by use of the known relationship between the resonance frequency and the position dependence of the magnetic field. EPR imaging has recently been recognized as an important tool for non-invasive, in vivo imaging of free radicals and reduction/oxidization metabolism. However, for in vivo EPR imaging of humans and large animals, the conventional approach is not suitable because (1) it is difficult to design and construct resonant cavities large enough and having the required shapes; (2) motion, including respiration and heartbeat, can alter the resonance frequency; and (3) most microwave energy is absorbed in the first few centimeters of tissue depth, thereby potentially endangering the subject and making it impossible to obtain adequate signal strength for imaging at greater depth. To obtain greater penetration depth, prevent injury to the subject, and avoid the difficulties associated with resonant cavities, it is necessary to use lower resonance frequencies. An additional advantage of using lower resonance frequencies is that one can use weaker applied magnetic fields: For example, for a resonance frequency of 1.4 MHz, one needs a magnetic flux density of 0.5 Gauss approximately the flux density of the natural magnetic field of the Earth.
Developments in and applications of fibre optic intrusion detection sensors (2002)

For many years optical fibre was the answer looking for the question. Now, after years of product applications and continued development, a range of fibre optic sensors are used in intrusion detection where the natural benefits of the material are matched by parallel developments in support technologies and applications experience. This paper describes some developments and applications in sensors and systems.
I band (8-10 GHz) TRAPATT-diode sources (1973)

The feasibility of a high-pulsed-power I band source using both n-type and p-type TRAPATT diodes has been demonstrated. Deep-diffused n-type diodes have generated more than 100 W in the I band.
A Real-time Rollover ThreatIndexforSportsUtilityVehicles (1999)

In this paper, the methodology capable of computing a Time-To-Rollover (TT’R) index in real-time [1] is verified by using test data of two Sports-Utility Vehicles (S W)-a 1988 Suzuki Samurai and a 1997 Jeep Cherokee. First, simple yaw-roll models are constructed based on the test data. The TTR is computed from the simple model and then corrected by using an Artificial Neural Network. The TT’R generated by the Neural Network is then verified against the data for the two test vehicles. 1.
The Lone Cypress, Monterey, California (2008)

The “Imagery” section of Spine is devoted to the artistic and imaginative qualities of our readers. Spine invites you to submit your drawings, illustrations, or photographs, along with appropriate explanatory information, for consideration of publication within this section. Please forward two 5" × 7" copies of your work to: Dr. William A. Abdu, Coordinating Editor “Imagery,” c/o Spine, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756. Tel: 603-653-9052 or 800-934-9379; Fax 603-653-9056.Figure: The Lone Cypress, Monterey, CaliforniaValorie Thomas, Raymore, Missouri
Deuxième partie. Les institutions (2002)

Le grand antagonisme entre capitalisme et communisme n’est plus. Le communisme s’est effondré ; le capitalisme a gagné. C’est du moins ce que nous pensons. Mais si nous regardons de plus près la structure des nations capitalistes victorieuses, nous avons du mal à dire jusqu’où elles sont « capitalistes ». Au Canada, les dépenses gouvernementales comptent pour bien au-delà de 40 %
State-space optimization of ETL workflows (2005)

Extraction-transformation-loading (ETL) tools are pieces of software responsible for the extraction of data from several sources, their cleansing, customization, and insertion into a data warehouse. In this paper, we derive into the logical optimization of ETL processes, modeling it as a state-space search problem. We consider each ETL workflow as a state and fabricate the state space through a set of correct state transitions. Moreover, we provide an exhaustive and two heuristic algorithms toward the minimization of the execution cost of an ETL workflow. The heuristic algorithm with greedy characteristics significantly outperforms the other two algorithms for a large set of experimental cases.
Robust Visual Tracking and Vehicle Classification via Sparse Representation (2011)

In this paper, we propose a robust visual tracking method by casting tracking as a sparse approximation problem in a particle filter framework. In this framework, occlusion, noise, and other challenging issues are addressed seamlessly through a set of trivial templates. Specifically, to find the tracking target in a new frame, each target candidate is sparsely represented in the space spanned by target templates and trivial templates. The sparsity is achieved by solving an l1-regularized least-squares problem. Then, the candidate with the smallest projection error is taken as the tracking target. After that, tracking is continued using a Bayesian state inference framework. Two strategies are used to further improve the tracking performance. First, target templates are dynamically updated to capture appearance changes. Second, nonnegativity constraints are enforced to filter out clutter which negatively resembles tracking targets. We test the proposed approach on numerous sequences involving different types of challenges, including occlusion and variations in illumination, scale, and pose. The proposed approach demonstrates excellent performance in comparison with previously proposed trackers. We also extend the method for simultaneous tracking and recognition by introducing a static template set which stores target images from different classes. The recognition result at each frame is propagated to produce the final result for the whole video. The approach is validated on a vehicle tracking and classification task using outdoor infrared video sequences.
The effect of environmental conditions on the start of dawn singing of blackbirds (Turdus merula) and bulbuls (Pycnonotidae). (2010)

Environmental pollution is known to influence bird behavior in many ways. In this study, the effect of noise, street lighting, moon light and weather conditions on the start of dawn singing of the two most common bird species in the area, bulbuls (Pycnonotus barbatus) and blackbirds (Turdus merula) is studied in a filed environment over a period of three autumn months. Results show that streetand moon lighting and the call for prayers by mosque loud speakers did not affect the start of singing compared to sunrise. Weather conditions (wind and rain) are the main factors that influenced the onset of singing in these two species. A relationship between sunrise and start of singing is established for blackbirds and bulbuls. Results show that sunlight,but not moonlight, affected the onset of dawn chorus in bulbuls and blackbirds. This study could serve as a record for similar future investigations on the influence of environmental conditions on birds behavior in the region. ﺮﺛﺄﺘﻳ ﻲﻓ ﺮﻴﻴﻐ ﺘﻟا ﺎﻬﻨﻣ قﺮﻃ ةﺪﻌﺑ ﻲﺧﺎﻨﻤﻟاو ﻲﺌﻴﺒﻟا ﺮﻴﻴﻐﺘﻟﺎﺑ رﻮﻴﻄﻟا كﻮﻠﺳ
Simultaneous measurement of strain and temperature using interferometrically interrogated fiber Bragg grating sensors (2000)

The potential of different fiber Bragg grating pairs for simultaneous sensing of strain and temperature is analyzed. We demonstrate that interferometric interrogation of a fiber grating written in bow-tie fiber enables strain and temperature to be simultaneously determined. This is achieved by independent measurement of the shift in the wavelengths of the reflected light from the grating components along the fast and the slow axes of the hi-bi fiber. A detailed theoretical analysis is presented that includes the basic sensing principle, sensor design and demodulation scheme. The performance of the proposed technique in simultaneous measurement of temperature and strain is experimentally demonstrated and resolutions of ± 2.5° c/?Hz and ± 26 ??/?Hz are obtained for a fiber with birefringence of B = 5.5x 10-4.
Maintaining high bandwidth under dynamic network conditions (2005)

The need to distribute large files across multiple wide-area sites is becoming increasingly common, for instance, in support of scientific computing, configuring distributed systems, distributing software updates such as open source ISOs or Windows patches, or disseminating multimedia content. Recently a number of techniques have been proposed for simultaneously retrieving portions of a file from multiple remote sites with the twin goals of filling the client&apos;s pipe and overcoming any performance bottlenecks between the client and any individual server. While there are a number of interesting tradeoffs in locating appropriate download sites in the face of dynamically changing network conditions, to date there has been no systematic evaluation of the merits of different protocols. This paper explores the design space of file distribution protocols and conducts a detailed performance evaluation of a number of competing systems running in both controlled emulation environments and live across the Internet. Based on our experience with these systems under a variety of conditions, we propose, implement and evaluate Bullet&apos; (Bullet prime), a mesh based high bandwidth data dissemination system that outperforms previous techniques under both static and dynamic conditions.
INVERSE RADIATION THERAPY PLANNING: A MULTIPLE OBJECTIVE OPTIMISATION APPROACH (1999)

AbstractFor some decades radiation therapy - external beam radiation therapy as well as brachytherapy - has been proved successful in cancer treatment. It is the major task of clinical radiation treatment planning to realise on the one hand a high level dose of radiation in the cancer tissue in order to obtain maximum tumour control. On the other hand it is obvious that it is absolutely necessary to keep in the tissue outside the tumour, particularly in organs at risk, the unavoidable radiation as low as possible. No doubt, these two objectives of treatment planning – high level dose in the tumour, low radiation outside the tumour – have a basically contradictory nature. Therefore, it is no surprise that inverse mathematical models with prescribed dose distributions tend to be infeasible in most cases. Thus, there is need for approximations compromising between overdosing the organs at risk and underdosing the target volume. Differing from the currently used time consuming iterative approach, which measures deviation from an ideal (non-achievable) treatment plan using recursively trial-and-error weights for the organs of interest, we go a new way trying to avoid a priori weight choices and consider the treatment planning problem as a multiple objective linear programming problem: with each organ of interest, target tissue as well as organs at risk, we associate an objective function measuring the maximal deviation from the prescribed doses. We build up a data base of relatively few efficient solutions representing and approximating the variety of Pareto solutions of the multiple objective linear programming problem. This data base can be easily scanned by physicians looking for an adequate treatment plan with the aid of an appropriate online tool.
Methodological Aspects of Prophylactic Drug Trials in Migraine (1981)

The purpose of this paper is to analyse methodological aspects of prophylactic drug trials in migraine. A study of ferrum quartz in 33 patients provided the necessary data base. Migraine definitions, relation between interval headache and migraine, and a number of other clinical problems are discussed. A headache diary is presented which to a certain extent allows a separation of internal headache and migraine attacks. Virtually all patients with frequent migraine attacks have interval headaches. A statistical model which allows a separation of time effects and treatment effects is presented. The inter-patient variability was much greater than intra-patient variability. This indicates that it will be difficult to obtain sufficient power with a non-crossover design. The relation between duration of treatment periods and the necessary number of patients is shown to be inversely related.
Concentration of antibiotics by reverse osmosis (1977)

Abstract Reverse osmosis is shown to be a viable process for the concentration of highly labile antibiotic solutions. Mathematical n10deJs of antibiotic inactivation by chemical and biological contamination are proposed and correlated with experimental data. Procedures for obtaining high antibiotic recoveries are discussed.
Robust Fisher's Test for Periodicity Detection in Noisy Biological Time Series (2007)

Periodicity detection in time series measurements is a usual application of signal processing in studying biological data. The reasons for detecting periodically behaving biological events are many, e.g. periodicity in gene expression time series could suggest cell cycle control over the gene expression. In this paper we present a robust version of the Fisher's test for detecting hidden periodicities in uniformly sampled time series data. The robust test performs better than the original test in case the data is not truly Gaussianly distributed. The proposed robust method is nearly as fast to evaluate as the original Fisher's test.
Experiments in algorithmic governance (2017)

This chapter describes a short-lived experiment in organizational governance that attempted to utilize algorithmic authority through cryptocurrency and block-chain technologies to create a social and political world quite unlike anything we have seen before. It details the governance structures that were promised by the developers and community members involved in the making of The decentralised autonomous organisation (DAO), and in contrast, those that were observed in its discourses before, during, and after the “exploit.” The DAO was a decentralized, crowdfunded, direct-management organization and investment platform. In the original vision of decentralized autonomous organizations, as proposed by Vitalik Buterin, founder and member of the Ethereum Foundation, a DAO is a pseudo-legal organization run by an assemblage of human and “robot” participants. From the earliest days of The DAO, many community members acknowledged that the enormous complexity of decentralized and algorithmic governance required a new kind of experimental “science” to map the “uncharted territory” The DAO was entering.
Hydrogenolysis of Ketals (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogenolysis of KetalsWILLIAM L. HOWARD and JOHN H. BROWN Jr.Cite this: J. Org. Chem. 1961, 26, 4, 1026–1028Publication Date (Print):April 1, 1961Publication History Published online1 May 2002Published inissue 1 April 1961https://pubs.acs.org/doi/10.1021/jo01063a010https://doi.org/10.1021/jo01063a010research-articleACS PublicationsRequest reuse permissionsArticle Views328Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oracle Certified Professional Financial Applications Consultant Exam Guide (2000)

Unit I: Preparing for OCP Exam I: Financial Management. 1: Introduction. 2: Financial Management Setup. 3: Basic Journal entries and Reporting. 4: Multiple-Currencies Accounting. 5: Oracle Assets Fundamentals. 6: Oracle Applications Integration. 7: Consolidation and Advanced Assets Functionality. Unit II: Preparing for OCP Exam 2: Applied Technology. 8: System Administration. 9: Flexfields. 10: Alerts. 11: Workflow. Unit III: Preparing for OCP Exam 3: Procurement. 12: Basic Purchasing and Receipts. 13: Document Approval and Invoice Entry. 14: Cash Management. 15: Advanced Purchasing. 16: Advanced Payables. Unit IV: Preparing for OCP Exam 4: Order Fulfillment. 17: Customer and Orders. 18: Basic Order Fulfillment. 19: Advanced Order Fulfillment. 20: Cash Management II.
Photoemission study of the existence of a valence-band satellite in Fe (1985)

The photon-energy dependence of the angle-resolved photoemission of Fe(110) has been measured to investigate the existence of a valence-band satellite. Contrary to the earlier observation of a satellite at about 6 eV below the Fermi edge, no satellite feature is found in the spectra measured on the clean surface, even for excitations around the 3p threshold. In spectra measured after exposing the surface to oxygen, a feature appears at about 6 eV. Such an oxygen-induced feature could spuriously be regarded as a valence-band satellite. The plot of the intensity of the main 3d band versus the excitation energy shows a profile with only a dip near the 3p threshold, while the similar plot for the ${M}_{23}$VV super Coster-Kronig emission has a profile with a single peak.
Interfacial force microscopy: Application to polymer surfaces (2000)

Scanning-probe microscopies (SPM) are presently widely used in remarkably diverse applications and, as evidenced by this symposium these techniques are rapidly expanding into the important areas of polymer surfaces and interfaces. The Atomic Force Microscope (AFM) is presently the most widely used of the scanning-probe techniques. However, the AFM's range of application suffers from an inherent mechanical instability in its deflection force sensor. The instability problem has been overcome by the development of the Interfacial Force Microscope (IFM), which utilizes a force-feedback sensor concept. In the following, the authors present several examples of polymer applications to illustrate the utility of the IFM sensor concept.
Vibration of the Abdomen in Non-Pregnant Sheep: Effect of Dynamic Force and Surface Area of Vibrator (1991)

Vibration exposure is a growing concern for increasing numbers of working pregnant women. The coupling between vibrating machines and the body determines to a great extent the degree of exposure and thus any maternal or foetal morbidity. In the present experiments we determined the effect of dynamic force and surface area of a vibrator on intraabdominal sound pressure level (SPL). Intraabdominal SPL was measured with a miniature hydrophone during mechanical vibration between 1–5000 Hz. Three different dynamic forces: 0.07, 0.14 and 0.42 newtons (N), and actuator head sizes: 2, 8 and 32 cm 2 were used with a constant static force of 9 N. Increasing the applied dynamic force increased the generated SPL (p<0.0001). The different actuator head sizes did not meaningfully affect sound transmissibility across frequencies.
Development of CPU module test device based on the virtual instrument (2011)

The current method for test CPU module is to load the Built-in-Test program in IDE 386 software, which is used to test all the performance of CPU module, and must run under Windows 98 operation system. But now because the most computers install the windows XP operation system, if the above method is used, so it's needed to install two operation systems on test computers. In order to realize the automatic test, CPU Module Test Device (CMTD) is designed and developed, which is used to test CPU module with various types and buses automatically. The virtual instrument PXI architecture is used to design the CMTD and simulate CPU bus signals, designed adapter is used to connect CPU signals with PXI bus module. Test-Item configuration file is used to describe the Test-Flow, and the Intel command is sent to CPU through RS-232 interface, the open-circuit and short-circuit test of all the CPU signals is realized using the propose of matrix switch and multimeter. Test software is designed under the graphical LabVIEW platform, and which realized the functions of system self-test, system calibration, Built-in-Test, covering test, test result query and report generation. Now the device is in use on CPU module production line, which improves the detection efficiency of CPU modules.