gebhart/patrepeval huggingface dataset:
ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models (2018)

Advances in oral SERDs development so far have been confined to nonsteroidal molecules such as those containing a cinnamic acid moiety, which are in earlystage clinical evaluation. ZB716 was previously reported as an orally bioavailable SERD structurally analogous to fulvestrant. In this study, we examined the binding details of ZB716 to the estrogen receptor alpha (ERα) by computer modeling to reveal its interactions with the ligand binding domain as a steroidal molecule. We also found that ZB716 modulates ERα-coregulator interactions in nearly identical manner to fulvestrant. The ability of ZB716 to inhibit cell growth and downregulate ER expression in endocrine resistant, ERα mutant breast cancer cells was demonstrated. Moreover, in both the MCF-7 xenograft and a patient derived xenograft model, orally administered ZB716 showed superior efficacy in blocking tumor growth when compared to fulvestrant. Importantly, such enhanced efficacy of ZB716 was shown to be attributable to its markedly higher bioavailability, as evidenced in the final plasma and tumor tissue concentrations of ZB716 in mice where drug concentrations were found significantly higher than in the fulvestrant treatment group.
Inhibition of Calcium Pyrophosphate Dihydrate Crystal Formation in Articular Cartilage Vesicles and Cartilage by Phosphocitrate (1996)

Articular cartilage vesicles (ACV), isolated by differential centrifugation of adult hyaline articular cartilage collagenase digests, mineralized in the presence of calcium and ATP. Mineral analysis by microscopy, chemical analysis, energy-dispersive analysis, and infrared spectroscopy revealed crystals resembling calcium pyrophosphate dihydrate (CPPD). Adult articular cartilage also underwent ATP-dependent mineralization, supporting the contention that vesicles in situ fostered adult articular cartilage mineralization. Phosphocitrate (PC) is a recognized in vitro inhibitor of hydroxyapatite and calcium oxalate monohydrate crystal formation, but it is not known whether PC can similarly restrict CPPD crystal development. In the present study we examine the effect of PC, citrate, and n-sulfo-2-amino-tricarballylate (SAT, a PC analogue) on the ATP-induced CPPD crystal formation in both ACV and articular cartilage models. Only PC (10-1000 microM) blocked both the ATP-dependent and -independent mineralization in ACV in a dose-dependent fashion. At 1 mM, SAT and citrate blocked the ATP-independent mineralization. Similarly, only PC blocked both the ATP- and non-ATP-dependent mineralization in native articular cartilage slices. PC, SAT, and citrate had no effect on ACV nucleoside triphosphate pyrophosphohydrolase activity, suggesting that none of these agents blocked mineralization through the inhibition of nucleoside triphosphate pyrophosphohydrolase activity, which generates inorganic pyrophosphate from ATP.
Forming Lipid Bilayer Membrane Arrays on Micropatterned Polyelectrolyte Film Surfaces (2013)

A novel method of forming lipid bilayer membrane arrays on micropatterned polyelectrolyte film surfaces is introduced. Polyelectrolyte films were fabricated by the layer-by-layer technique on a silicon oxide surface modified with a 3-aminopropyltriethoxysilane (APTES) monolayer. The surface pK(a) value of the APTES monolayer was determined by cyclic voltammetry to be approximately 5.61, on the basis of which a pH value of 2.0 was chosen for layer-by-layer assembly. Micropatterned polyelectrolyte films were obtained by deep-UV (254 nm) photolysis though a mask. Absorbed fluorescent latex beads were used to visualize the patterned surfaces. Lipid bilayer arrays were fabricated on the micropatterned surfaces by immersing the patterned substrates into a solution containing egg phosphatidylcholine vesicles. Fluorescence recovery after photobleaching studies yielded a lateral diffusion coefficient for probe molecules of 1.31±0.17 μm(2) s(-1) in the bilayer region, and migration of the lipid NBD PE in bilayer lipid membrane arrays was observed in an electric field.
The Fatigue Severity Scale (1989)

Fatigue is a prominent disabling symptom in a variety of medical and neurologic disorders. To facilitate research in this area, we developed a fatigue severity scale, subjected it to tests of internal consistency and validity, and used it to compare fatigue in two chronic conditions: systemic lupus erythematosus and multiple sclerosis. Administration of the fatigue severity scale to 25 patients with multiple sclerosis, 29 patients with systemic lupus erythematosus, and 20 healthy adults revealed that the fatigue severity scale was internally consistent, correlated well with visual analogue measures, clearly differentiated controls from patients, and could detect clinically predicted changes in fatigue over time. Fatigue had a greater deleterious impact on daily living in patients with multiple sclerosis and systemic lupus erythematosus compared with controls. The results further showed that fatigue was largely independent of self-reported depressive symptoms and that several characteristics could differentiate fatigue that accompanies multiple sclerosis from fatigue that accompanies systemic lupus erythematosus. This study demonstrates (1) the clinical and research applications of a scale that measures fatigue severity and (2) helps to identify features that distinguish fatigue between two chronic medical disorders.
Ultrashort laser pulse ablation of copper, silicon and gelatin: effect of the pulse duration on the ablation thresholds and the incubation coefficients (2016)

In this paper, the influence of the pulse duration on the ablation threshold and the incubation coefficient was investigated for three different types of materials: metal (copper), semiconductor (silicon) and biopolymer (gelatin). Ablation threshold values and the incubation coefficients have been measured for multiple Ti:sapphire laser pulses (3 to 1000 pulses) and for four different pulse durations (10, 30, 250 and 550 fs). The ablation threshold fluence was determined by extrapolation of curves from squared crater diameter versus fluence plots. For copper and silicon, the experiments were conducted in vacuum and for gelatin in air. For all materials, the ablation threshold fluence increases with the pulse duration. For copper, the threshold increases as τ 0.05, for silicon as τ 0.12 and for gelatin as τ 0.22. By extrapolating the curves of the threshold fluence versus number of pulses, the single-shot threshold fluence was determined for each sample. For 30 fs pulses, the single-shot threshold fluences were found to be 0.79, 0.35, and 0.99 J/cm2 and the incubation coefficients were found to be 0.75, 0.83 and 0.68 for copper, silicon and gelatin, respectively.
Polyunsaturated fatty acids in plasma, red blood cells and mononuclear cell phospholipids of patients with atopic dermatitis (1992)

Recent studies of polyunsaturated fatty acids (PUFA) in plasma and blood cell components of patients with atopic diseases have indicated disordered fat metabolism as linoleic acid (18:2n-6) tends to be increased while the more unsaturated fatty acids, such as gamma-linolenic acid (18:3n-6) and arachidonic acid (20:4n-6) are present in decreased amounts. To further clarify these abnormalities, we examined the PUFA content in phospholipids derived from plasma, red blood cells and mononuclear cells (MNC) in patients with atopic dermatitis. In plasma no significant differences were found between patients and controls. In red blood cells dihomo-gamma-linolenic acid (20:3n-6) was reduced in eczema patients, as compared with controls. The most significant findings in eczema patient MNC were reduced ratios of 20:4n-6/20:3n-6 in total lipids and in phosphatidyl ethanolamine (PE) and of 20:4n-6/18:2n-6 in both total lipids, phosphatidyl choline (PC) and PE. These findings indicate a disordered fatty acid metabolism in MNC of patients with atopic dermatitis. It is possible that these changes in the fatty acid profile of MNC may account for some of the immunological abnormalities seen in these patients.
Color Atlas of Endourology (1999)

This full-color surgical atlas focuses on normal endourologic anatomy and its variants. Every essential aspect is given clear, in-depth examination, offering expert guidance through this complex subject. Divided into two sections -- one focusing on endoscopic/ureteroscopic views, the other on laparoscopic views -- the text presents a range of structures, enabling the reader to more easily differentiate normal from abnormal appearances. An abundance of full-color illustrations, accompanied by brief descriptive captions, help to clarify key features
Coincident cold urticaria in a married couple: case report and a literature review. (1997)

We describe an interesting coincidence in which a woman developed acquired idiopathic cold urticaria and her husband systemic cold urticaria eight months later. The occurrence of cold urticaria in a tropical country like Singapore is rare. Each case illustrates the typical features of that particular type of cold urticaria, including the appropriate response to the challenge test and its self-limited nature.
Detection of Micrometastatic Tumor Cells in pN0 Lymph Nodes of Patients With Completely Resected Nonsmall Cell Lung Cancer (2002)

The detection of lymph nodal micrometastasis by cytokeratin and p53 protein immunohistochemical staining will be helpful to predict the recurrence and prognosis of patients with completely resected stage 1 NSCLC.
Automated classification of alternative splicing and transcriptional initiation and construction of visual database of classified patterns (2006)

The data detected by this system are available through ASTRA (http://alterna.cbrc.jp/), a database equipped with a Java-based browser that can interactively reorganize the order of displayed splicing patterns on demand.
Present and Future Capabilities of the Online Journal (1995)

traditional paper journals offer a number of VERSIONS OF advantages, most of which have been more than offset by the electronic journals' disadvantages.Advances in computing developed primarily for the office environment are reducing the technical disadvantages to the point where electronic formats are rapidly approaching parity of ease of use and convenience with paper.Electronic journals are currently being developed in three main formats: simple text, page image, and structured text.Each of these formats has its own strengths and weaknesses, and there are some combinations of the three that offer interesting capabilities.Automation is often described as automating what we currently do, which in turn changes what we do, resulting in another generation of automation.In many ways, changing what we do occurs simultaneously with the automation of an activity as users of information develop new ways to use the electronic medium.The role traditional journals play is changing as it becomes much easier for individuals to publish articles directly.
Resonant frequencies of a rectangular cantilever beam immersed in a fluid (2006)

The resonant frequencies of cantilever beams can depend strongly on the fluid in which they are immersed. In this article, we expand on the method of Elmer and Dreier [J. Appl. Phys. 81, 7709 (1997)] and derive explicit analytical formulas for the flexural and torsional resonant frequencies of a rectangular cantilever beam immersed in an inviscid fluid. These results are directly applicable to cantilever beams of macroscopic size, where the effects of viscosity are negligible, and are valid for arbitrary mode number. In contrast to low mode numbers, in all cases it is found that the fluid has no effect on the resonant frequencies in the limit of infinite mode number.
The Devil in the Bioethics Classroom (1985)

Research Article| February 01 1985 The Devil in the Bioethics Classroom Newtol Press Newtol Press Search for other works by this author on: This Site PubMed Google Scholar The American Biology Teacher (1985) 47 (2): 94–95. https://doi.org/10.2307/4447959 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Newtol Press; The Devil in the Bioethics Classroom. The American Biology Teacher 1 February 1985; 47 (2): 94–95. doi: https://doi.org/10.2307/4447959 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe American Biology Teacher Search This content is only available via PDF. Copyright 1984 The National Association of Biology Teachers Article PDF first page preview Close Modal You do not currently have access to this content.
An Algorithm for Generation of Attack Signatures Based on Sequences Alignment (2008)

This paper presents a new algorithm for generation of attack signatures based on sequence alignment. The algorithm is composed of two parts: a local alignment algorithm-GASBSLA (Generation of Attack Signatures Based on Sequence Local Alignment) and a multi-sequence alignment algorithm-TGMSA (Tri-stage Gradual Multi-Sequence Alignment). With the inspiration of sequence alignment used in Bioinformatics, GASBSLA replaces global alignment and constant weight penalty model by local alignment and affine penalty model to improve the generality of attack signatures. TGMSA presents a new pruning policy to make the algorithm more insensitive to noises in the generation of attack signatures. In this paper, GASBSLA and TGMSA are described in detail and validated by experiments.
Indoor Air Monitoring System Based on Internet of Things and Its Prediction Model (2019)

Urban residents work indoors for a long time, and indoor air quality is becoming an important indicator that residents care about in their work and life. Based on the Internet of Things, this paper designs an indoor air monitoring system, which can monitor and collect various parameters of indoor air in real time, upload them to the data center for analysis, and push them to the user end for display. Meanwhile, a prediction model is established to predict the air quality indicator in the next few hours by taking CO2 as an example, and construct a complete air quality evaluation to provide to users, so that other intelligent terminals or users can adjust the doors and windows, to make ensure the excellent indoor air quality.
The amidase activity of human tissue kallikrein is significantly higher in the urine of patients with either type 1 or gestational diabetes mellitus (2010)

The levels of tissue kallikrein are reduced in humans with hypertension, cardiovascular and renal diseases. There is little information on the participation of human tissue (renal/urinary) kallikrein (hK1) in type 1 diabetes mellitus (DM), and, no information concerning the role of hK1 was reported in gestational diabetes mellitus (GDM). The present study evaluated the roles of insulin and hyperglycemia on urinary hK1 activity in type 1 DM and in GDM. Forty three type 1 DM patients (535 years, disease duration  5 years, receiving insulin, HbA1c &gt; 7.6%) were selected. Forty three healthy individuals, paired according to gender and age, were used as controls. Thirty GDM patients (18−42 years, between the 24th and 37th weeks of pregnancy, recently diagnosed, not under insulin therapy) were also selected. Thirty healthy pregnant and thirty healthy non−pregnant women (18−42 years) were selected as controls. A random midstream urine was used. hK1 amidase activity was estimated with D-Val-Leu-Arg-Nan substrate. Albumin was determined with Coomassie Brilliant Blue reagent. Creatinine was determined by Jaffe's method. hK1 specific amidase activity was expressed as μM/(min/mg creatinine to correct for differences in urine flow rate. hK1 specific amidase activity was significantly higher in the urine of type 1 DM and GDM patients, respectively, than in controls. These findings suggest that hyperglycemia rather insulin is involved in the mechanism of increased hK1 specific amidase activity in the urine of both type 1 DM and GDM patients. Albumin/creatinine ratio was increased in type 1 DM, GDM and healthy pregnant women.
Repetitive sequences involved in the recombination leading to deletion of exon 5 of the low‐density‐lipoprotein receptor gene in a patient with familial hypercholesterolemia (1991)

Alu sequences in the low-density-lipoprotein (LDL) receptor gene are suspected of being of importance for the creation of gene defects leading to familial hypercholesterolemia (FH). One potential mechanism is that Alu sequences undergo homologous recombination, producing deletions or duplications of DNA segments on genomic DNA. In at least four cases (FH626, PO, JA and FH-DK3), a deletion of exon 5 of the LDL receptor gene has been reported. Only one of these (FH626) have so far been characterized in detail by sequence analysis and shown to involve two of the Alu repeated sequences, which are present in introns 4 and 5. We here report the complete characterization of FH-DK3 and show that the cross-over break points involve sequences similar, but not at identical positions in the 5' end, to those reported for FH626. The recombinations in both FH-DK3 and FH626 are suggested to have occurred within a 22-bp repeated sequence found in both junction alleles.
Multiple Criteria Rainfall-Runoff Model Calibration Using a Parallel Genetic Algorithm in a Cluster of Computers (2006)

Abstract Genetic algorithms are among of the global optimization schemes that have gained popularity as a means to calibrate rainfall–runoff models. However, a conceptual rainfall–runoff model usually includes 10 or more parameters and these are interdependent, which makes the optimization procedure very time-consuming. This may result in the premature termination of the optimization process which will prejudice the quality of the results. Therefore, the speed of optimization procedure is crucial in order to improve the calibration quality and efficiency. A hybrid method that combines a parallel genetic algorithm with a fuzzy optimal model in a cluster of computers is proposed. The method uses the fuzzy optimal model to evaluate multiple alternatives with multiple criteria where chromosomes are the alternatives, whilst the criteria are flood performance measures. In order to easily distinguish the performance of different alternatives and to address the problem of non-uniqueness of optimum, two fuzzy rati...
Influence of Microstructural Bias on the Hugoniot Elastic Limit and Spall Strength of Two-Phase TiB2+Al2O3 Ceramics (2002)

The influence of microstructural bias on the Hugoniot Elastic Limit and spall strength of two‐phase TiB2+Al2O3 ceramics was investigated in this study. The microstructural bias includes differences in phase (grain) size and phase distribution such that in one case a continuous (interconnected) TiB2 network surrounds the Al2O3 phase, and in another case the TiB2 and Al2O3 phases are interdispersed and uniformly inter‐twined with each other. Dynamic compression and tension (spall) properties were measured using plate‐impact gas‐gun experiments. The measurements used piezoelectric PVDF stress gauges to obtain the loading profile and determine the Hugoniot Elastic Limit, and VISAR interferometry to obtain the spall signal and determine tensile properties. The experimental results reveal that while the strength under dynamic compression (HEL) is more dominantly dependent on the phase size, the tensile spall strength scales with the connectivity of the TiB2 phase.
Improvement of the Micromethod for the Limulus Lysate Test (1978)

Frauch's micro-slide method was improved to facilitate the endpoint-determination of the Limulus test. Two precise observations, by inverted phase contrast microscopy and with a staining procedure, were newly performed as additions to the slide test. The staining procedure was proposed as an improved method for the Limulus test since it is simple and convenient. In the staining method, bromophenol blue (BPB) solution was used as the staining solution. A negative (-), a strong positive (++) and a weak positive reaction (+) were characterized by a "ring" formation, a "cloud-like" spread of gel and a "spot" in the "cloud" respectively. Since the distinction between (-) and (+) reactions was obvious in the proposed method, determination of the endpoint was easier than in the ordinary tube and Frauch's method. The sensitivity of the present method was equal to or higher than that of other methods. Inverted phase contrast microscopy was utilized to confirm the findings obtained by the staining method. The volume of the lysate used in this method was as little as 1/10 of that used in the tube method.
High electron and hole mobility enhancements in thin-body strained Si/strained SiGe/strained Si heterostructures on insulator (2005)

Fully depleted MOSFETs were fabricated on strained Si/strained SiGe (46% Ge)/strained Si heterostructures on insulator (HOI) for the first time, demonstrating both high electron and hole mobility enhancements while maintaining excellent subthreshold characteristics. The total thickness of the heterostructure on insulator is less than 25 nm. At an inversion charge density of 1.5/spl times/10/sup 13/ cm/sup -2/, mobility enhancements of 90% and 107% are obtained for electrons and holes respectively. The mobility increases as the cap thickness is reduced to 2 nm. HOI offers superior hole mobility than 40% strained silicon directly on insulator at all vertical fields, when the cap thickness is below 5 nm.
Superoxide in organic synthesis: a new mild method for the oxidation of amines to carbonyls via N-chloramines (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuperoxide in organic synthesis: a new mild method for the oxidation of amines to carbonyls via N-chloraminesFrank E. Scully Jr. and Richard C. DavisCite this: J. Org. Chem. 1978, 43, 7, 1467–1468Publication Date (Print):March 1, 1978Publication History Published online1 May 2002Published inissue 1 March 1978https://pubs.acs.org/doi/10.1021/jo00401a041https://doi.org/10.1021/jo00401a041research-articleACS PublicationsRequest reuse permissionsArticle Views405Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A comparative study of extraction techniques for maximum recovery of glutamate decarboxylase (GAD) from Aspergillus oryzae NSK (2013)

Of the techniques used to extract GAD from A. oryzae NSK, sonication was found to be the best. Under optimized conditions, about 176% of GAD was recovered compared to recovery under non optimized conditions. The high production level of GAD in this strain offers an opportunity to conduct further studies on GABA production at a larger scale.