gebhart/patrepeval huggingface dataset:
Compressibility and Fractal Dimension of Fine Coal Particles in Relation to Pore Structure Characterisation Using Mercury Porosimetry (1999)

Mercury porosimetry has been applied to characterize the pore structure of fine coals particles. Interparticle voids and compressibility effects on the mercury intrusion data were examined. It is found that coal compressibility has a significant effect on mercury porosimetry data when pressure P>20 MPa. The compressibility of the two coals used was determined to be 3.13×10−10 m2 N−1 and 2.50×10−10 m2 N−1 for CA and GO coals, respectively. Fractal dimension analysis provides a “fingerprint” to distinguish the effect of coal compression from the pore filling process during mercury intrusion. It is shown that fractal dimension can be evaluated from the compressibility corrected pore volume data. Results from the present study suggest that statistic self-similarity of the fractal dimension perspective is limited by certain artificial effects, such as crushing and grinding. Different surface irregularities exist over different pore size ranges, and a single fractal dimension value can only be used to describe the surface irregularity within a limited pore size range. The average fractal dimensions in the pore size range of 6–60 nm were found to be 2.71 and 2.43 for CA and GO coals, respectively.
Epac Mediates β-Adrenergic Receptor–Induced Cardiomyocyte Hypertrophy (2008)

Cardiac hypertrophy is promoted by adrenergic overactivation and can progress to heart failure, a leading cause of mortality worldwide. Although cAMP is among the most well-known signaling molecules produced by beta-adrenergic receptor stimulation, its mechanism of action in cardiac hypertrophy is not fully understood. The identification of Epac (exchange protein directly activated by cAMP) proteins as novel sensors for cAMP has broken the dogma surrounding cAMP and protein kinase A. However, their role and regulation in the mature heart remain to be defined. Here, we show that cardiac hypertrophy induced by thoracic aortic constriction increases Epac1 expression in rat myocardium. Adult ventricular myocytes isolated from banded animals display an exaggerated cellular growth in response to Epac activation. At the molecular level, Epac1 hypertrophic effects are independent of its classic effector, Rap1, but rather involve the small GTPase Ras, the phosphatase calcineurin, and Ca(2+)/calmodulin-dependent protein kinase II. Importantly, we find that in response to beta-adrenergic receptor stimulation, Epac1 activates Ras and induces adult cardiomyocyte hypertrophy in a cAMP-dependent but protein kinase A-independent manner. Knockdown of Epac1 strongly reduces beta-adrenergic receptor-induced hypertrophic program. Finally, we report for the first time that Epac1 is mainly expressed in human heart as compared with Epac2 isoform and is increased in heart failure. Taken together, our data demonstrate that the guanine nucleotide exchange factor Epac1 contributes to the hypertrophic effect of beta-adrenergic receptor in a protein kinase A-independent fashion and may, therefore, represent a novel therapeutic target for the treatment of cardiac disorders.
A double-blind randomized trial of nicotine nasal spray as an aid in smoking cessation (1997)

The objective of the study was to evaluate the therapeutic efficacy of nicotine nasal solution (NNS) for smoking cessation from the stopping day up to 3 months. We also followed the participants for 2 yrs after ceasing smoking to assess what happens after stopping using NNS. In a placebo-controlled, double-blind, 2 yr prospective study, 157 smokers were given either NNS, one dose containing 1 mg of nicotine per 100 microL (n=79), or placebo (n=78). Treatment was continued for up to 1 yr. One day after quitting smoking, the average number of daily doses was 11 in the group assigned NNS and 14 in the group assigned the placebo, and after 6 weeks, 14 and 6 doses, respectively, among abstinent participants still using spray. After 3 months, 65% of the abstainers in the nicotine group were still using the NNS. The abstinence rates were 51, 39 and 29% after 6 weeks, 3 and 6 months, respectively, as compared to 24, 19 and 18% in the placebo group (p=0.0003; p=0.003; p=0.050). The proportion abstinent at the 1 yr (25 vs 17%) and 2 yr follow-ups (19 vs 14%) was higher among those assigned to the nicotine than to the placebo group, but not significantly so for the numbers used in the study. In conclusion, the use of nicotine nasal spray significantly increased the abstinence rate during the first 6 months following the quitting day.
The modes of an axially slotted coaxial waveguide (1979)

By using a quasi‐static integral equation technique a transcendental equation for the propagation constants of an axially slotted, dielectric‐filled coaxial waveguide is obtained. The equation is solved on the computer, and curves of the propagation constants versus various line parameters are presented. Also calculated are expressions for the transfer impedance and field quantities.
An Electrothermal Carbon Nanotube Gas Sensor (2007)

We show both gas pressure and species sensing capabilities based on the electrothermal effect of a multiwalled carbon nanotube (MWCNT). Upon exposure to gaseous environments, the resistance of a heated MWCNT is found to change following the conductive heat-transfer variances of gas molecules. To realize this mechanism, a suspended MWCNT is constructed by synthesis and assembly in localized chemical vapor deposition that is accomplished within seconds via real-time electrical feedback control. Vacuum pressure sensitivity and gas species differentiability are observed and analyzed. Such MWCNT electrothermal sensors are compact, fast and reversible in responses, and fully integratable with microelectronics.
Turn-taking phenomena in incremental dialogue systems (2015)

In this paper, a turn-taking phenomenon taxonomy is introduced, organised according to the level of information conveyed. It is aimed to provide a better grasp of the behaviours used by humans while talking to each other, so that they can be methodically replicated in spoken dialogue systems. Five interesting phenomena have been implemented in a simulated environment: the system barge-in with three variants (resulting from either an unclear, an incoherent or a sufficient user message), the feedback and the user barge-in. The experiments reported in the paper illustrate that how such phenomena are implemented is a delicate choice as their impact on the system's performance is variable.
Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous<i>in vitro</i>fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study (2011)

The treatment with myo-inositol and melatonin improves ovarian stimulation protocols and pregnancy outcomes in infertile women with poor oocyte quality.
A fast image matching technique for the panoramic-based localization (2016)

This paper proposes a novel image tracking technique for the image-based positioning study on the mobile device. The study uses the panorama as the indoor map to localize the user. Since the number of feature points of the panorama is much larger than feature points from the image of the mobile device, the performance of matching mobile device image with the panorama will significantly affect the efficiency of the positioning. Hence, a Sorting Hat approach is proposed to filter out uncorrelated feature pairs as early as possible. The Sorting Hat is designed according to the characteristic of BRISK which is adopted as feature detection technique in this study. However, since the coordinates of the panorama is not the same as that of mobile device image, a coordinates unification is proposed to improve the effectiveness of image matching. To further improve the image matching speed during the positioning process, a Reckon-View mechanism on the panorama is also proposed. Our experiments show that the Sorting Hat approach can decide if two feature points are correlated within 0.824ms at 99.6% confidence. Furthermore, the experiment also prove that the Reckon-View mechanism can reduce the number of feature pairs computation to two-thirds of the original.
An introduction to buildings cybersecurity framework (2017)

This paper presents an introduction to the Buildings Cybersecurity Framework (BCF). The BCF provides the organizations with a set of cybersecurity best practices, policies and procedures to improve their cybersecurity posture; defines structured methodologies to interact cybersecurity activities and outcomes from the executive to operations levels. The foundation of the BCF core is based on five core elements defined by the National Institute of Standards and Technology (NIST) Cybersecurity Framework: Identify, Protect, Detect, Respond and Recover. Those five core elements were crafted to address evolving cybersecurity threats and vulnerabilities. With the BCF, an organization will be able to: assess their target cybersecurity state and current cybersecurity posture; identify and prioritize improvement opportunities and necessary actions by continuous and repeatable process; assess progress towards the target state; and communicate cybersecurity risk among internal and external stakeholders. This paper is a miniature of the ∼100-page Buildings Cybersecurity Framework, and the goal of this paper is to explicate the applicability of BCF in different types of buildings such as Residential, Small Commercial, Large Commercial, and Federal buildings. Note that the framework itself is a detailed version of the various aspects discussed in this paper.
Negative Refractive Index in Left-Handed Materials (2000)

The real part of the refractive index n(omega) of a nearly transparent and passive medium is usually taken to have only positive values. Through an analysis of a current source radiating into a 1D "left-handed" material (LHM)-where the permittivity and permeability are simultaneously less than zero-we determine the analytic structure of n(omega), demonstrating frequency regions where the sign of Re[n(omega)] must, in fact, be negative. The regime of negative index, made relevant by a recent demonstration of an effective LHM, leads to unusual electromagnetic wave propagation and merits further exploration.
Attachments, reasons, and desires (2006)

… & is he honest who resists his genius or conscience only for the sake of present ease or gratification?William Blake
HIV Infection, Immune Suppression, and Uncontrolled Viremia Are Associated With Increased Multimorbidity Among Aging Injection Drug Users (2011)

HIV-infected participants experienced increased numbers of multimorbid conditions; risk increased with advanced immunosuppression and higher viremia. These results underscore the heavy burden of multimorbidity associated with HIV and highlight the need for incorporating routine assessment and integrated management of chronic diseases as part of comprehensive healthcare for aging, HIV-infected persons.
A case study of the ERP system application in the aviation maintenance department of H company (2008)

This paper takes the system implementation of an enterprise as an example, through the analysis of the business process of an aviation maintenance enterprise, the demand of enterprise, and actual system structure, we analyze how the enterprise to implement a standard customized system in the actual business activities through the analysis of their internal needs and system investigation. We mainly discuss two questions about the implementation of ERP system: First, how to make the business and the system coincident. Secondly, how the enterprises success by implementing ERP system through adjusting the ERP system according to their reality.
Baron Corvo (1955)

Journal Article Baron Corvo Get access A. C. E. A. C. E. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CC, Issue jan, 1 January 1955, Page 42, https://doi.org/10.1093/nq/CC.jan.42c Published: 01 January 1955
A Fully Digital Delay Line Based GHz Range Multimode Transmitter Front-End in 65-nm CMOS (2012)

This paper presents a fully digital polar up-converter for wireless transmission in the GHz range. The system is designed to drive two class-E power amplifiers (PAs) with a power combiner. It uses baseband pulse width modulation (PWM) for the amplitude modulation (AM), whereas phase modulation (PM) is implemented by shifting the RF carrier in time. Both the PWM and the PM are implemented using asynchronous delay lines which allow time resolutions down to 10 ps without the need for any reference frequencies higher than the carrier frequency. The system supports a continuous range of carrier frequencies from 946 MHz up to 2.4 GHz. It also supports a continuous range of sampling frequencies, which allows trading off signal quality for PA efficiency. The modulator has been implemented in 65-nm low-power CMOS. Measurements using 64-QAM OFDM signals show error vector magnitude (EVM) values ranging from 1.90% (-34.4 dB) for 5-MHz bandwidth signals at 946 MHz to 6.08% (-24.3 dB) for 20-MHz bandwidth signals at 2.4 GHz.
Particle swarm optimization for nonlinear spectral unmixing: A case study of generalized bilinear model (2016)

Spectral unmixing is a key procedure of hyperspectral remote sensing analysis. Recently, nonlinear unmixing becomes a hotspot in this research field. However, due to the complexity of the nonlinear mixing models (nonLMM), it is trivial to develop an algorithm for nonlinear unmixing. Particle Swarm Optimization (PSO) is a classical algorithm of natural computation, which presents a great potential of nonlinear unmixing. Specially, it employs only a fitness value directly determined by the nonLMM, and does not need any information concerning about the gradient, hessian matrix, or probability distributions. Thus, it can be easily applied to characterize complex nonLMMs. In this paper, we develop a biswarm (double swarm) PSO algorithm for nonlinear unmixing, with a case study of generalized bilinear model (GBM). The experimental results indicate that the proposed algorithm outperforms other traditional algorithms for hyperspectral images. As a result, we can conclude that the PSO algorithm is an excellent method for addressing nonlinear unmixing problem.
Design for Social Sustainability at Seattle's Central Library (2007)

Abstract As a culture we hold dear social values such as public good, health and well-being, quality of life, diversity, and equity. The focus of this article is how Seattle's Central Library, a Silver LEED™ project, integrates social benefit into its design. While LEED provides credit opportunities for some social issues, many are not addressed by the LEED System. The Seattle project provides a rich example of how to integrate a broader range of social sustainability into green design thinking. Issues for consideration include: design to encourage social interaction, accessibility, economic development, cultural arts, and improved staff efficiency and ergonomics. This discussion searches for lessons learned that might inspire the emergence of new LEED credits.
Gel electrophoresis of human tears reveals various forms of tear lactoferrin (1989)

Lactoferrin is a metal binding protein, which is present in high concentrations in human tears. Little is known concerning the exact molecular shape of lactoferrin in tears. Sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting experiments showed that this protein is present in multiple forms in tear fluid. SDS-PAGE analysis of human tears under non reducing conditions and pretreatment of tears in sample buffer at room temperature revealed lactoferrin in a major form of 60 kD, a minor form of 64 kD and a third form of 52 kD. Pretreatment of tears at elevated temperatures prior to sample application resulted in the loss of this third form. Disruption of intrachain disulfide bridges prior to SDS-PAGE analysis resulted in a shift in the apparent molecular weight of lactoferrin to 78 kD and 83 kD for the major and minor form, respectively. Chromatography of human tears on ConA-Sepharose as well as enzymatic deglycosylation showed that the difference in molecular weight of the major and minor lactoferrin form was not due to a variation in the carbohydrate side chains. The presence of the minor form could also not be ascribed to iron saturation. Instead we found that addition of iron ions to human tears resulted in a shift of tear lactoferrin to a lower molecular weight species of about 52 kD, coinciding with the third lactoferrin form mentioned above and a small protein band of approximately 57 kD, representing the iron saturated minor lactoferrin form. Similar findings were observed using purified milk lactoferrin. Increasing the temperature prior to sample application or disruption of disulfide bridges dissociated the iron-lactoferrin complex.(ABSTRACT TRUNCATED AT 250 WORDS)
[Distribution of individuals by spontaneous frequencies of lymphocytes with micronuclei. Particularity and consequences]. (2011)

By micronucleus (MN) assay with cytokinetic cytochalasin B block, the mean frequency of blood lymphocytes with MN has been determined in 76 Moscow inhabitants, 35 people from Obninsk and 122 from Chelyabinsk region. In contrast to the distribution of individuals on spontaneous frequency of cells with aberrations, which was shown to be binomial (Kusnetzov et al., 1980), the distribution of individuals on the spontaneous frequency of cells with MN in all three massif can be acknowledged as log-normal (chi2 test). Distribution of individuals in the joined massifs (Moscow and Obninsk inhabitants) and in the unique massif of all inspected with great reliability must be acknowledged as log-normal (0.70 and 0.86 correspondingly), but it cannot be regarded as Poisson, binomial or normal. Taking into account that log-normal distribution of children by spontaneous frequency of lymphocytes with MN has been observed by the inspection of 473 children from different kindergartens in Moscow we can make the conclusion that log-normal is regularity inherent in this type of damage of lymphocytes genome. On the contrary the distribution of individuals on induced by irradiation in vitro lymphocytes with MN frequency in most cases must be acknowledged as normal. This distribution character points out that damage appearance in the individual (genomic instability) in a single lymphocytes increases the probability of the damage appearance in another lymphocytes. We can propose that damaged stem cells lymphocyte progenitor's exchange by information with undamaged cells--the type of the bystander effect process. It can also be supposed that transmission of damage to daughter cells occurs in the time of stem cells division.
Role of inflammatory cytokines in peripheral nerve injury (2012)

Inflammatory events occurring in the distal part of an injured peripheral nerve have, nowadays, a great resonance. Investigating the timing of action of the several cytokines in the important stages of Wallerian degeneration helps to understand the regenerative process and design pharmacologic intervention that promotes and expedites recovery. The complex and synergistic action of inflammatory cytokines finally promotes axonal regeneration. Cytokines can be divided into pro- and anti-inflammatory cytokines that upregulate and downregulate, respectively, the production of inflammatory mediators. While pro-inflammatory cytokines are expressed in the first phase of Wallerian degeneration and promote the recruitment of macrophages, anti-inflammatory cytokines are expressed after this recruitment and downregulate the production of all cytokines, thus determining the end of the process. In this review, we describe the major inflammatory cytokines involved in Wallerian degeneration and the early phases of nerve regeneration. In particular, we focus on interleukin-1, interleukin-2, interleukin-6, tumor necrosis factor-β, interleukin-10 and transforming growth factor-β.
Human Colostrum and Serum Contain Antibodies Reactive to the Intimin-Binding Region of the Enteropathogenic Escherichia coli Translocated Intimin Receptor (2000)

The intimin-binding region of Tir (Tir-M) is the immunodominant region of the polypeptide in humans. Both serum IgG-class and colostrum IgA-class antibodies reacted predominantly with the Tir-M domain.
Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate (2016)

DMF activates Nrf2, enhances antioxidant defenses, and inhibits inflammation and vaso-occlusion in SCD mice. Antioxid. Redox Signal. 26, 748-762.
Synthesis and Photovoltaic Effect of Electron-Withdrawing Units for Low Band Gap Conjugated Polymers Bearing Bi(thienylenevinylene) Side Chains (2019)

A novel (<i>E</i>)-5-(2-(5-alkylthiothiophen-2-yl)vinyl)thien-2-yl (TVT)-comprising benzo[1,2-b:4,5-b']dithiophene (BDT) derivative (BDT-TVT) was designed and synthetized to compose two donor-acceptor (D-A) typed copolymers (PBDT-TVT-ID and PBDT-TVT-DTNT) with the electron-withdrawing unit isoindigo (ID) and naphtho[1,2-c:5,6-c']bis[1,2,5]thiadiazole (NT), respectively. PBDT-TVT-ID and PBDT-TVT-DTNT showed good thermal stability (360 °C), an absorption spectrum from 300 nm to 760 nm and a relatively low lying energy level of Highest Occupied Molecular Orbital (<i>E</i><sub>HOMO</sub>) (-5.36 to -5.45 eV), which could obtain a large open-circuit voltage (<i>V</i><sub>oc</sub>) from photovoltaic devices with PBDT-TVT-ID or PBDT-TVT-DTNT. The photovoltaic devices with ITO/PFN/polymers: PC<sub>71</sub>BM/MoO<sub>3</sub>/Ag structure were assembled and exhibited a good photovoltaic performance with a power conversion efficiency (PCE) of 4.09% (PBDT-TVT-ID) and 5.44% (PBDT-TVT-DTNT), respectively. The best PCE of a PBDT-TVT-DTNT/PC<sub>71</sub>BM-based device mainly originated from its wider absorption, higher hole mobility and favorable photoactive layer morphology.
Management of Acute Sulfide Poisoning (1976)

Oxygen (100% at 1 atmosphere) did not protect mice against death from acute sulfide poisoning as compared with animals maintained under air at 1 atmosphere. Sodium thiosulfate had a small, but statistically significant (P less than .05) protective effect against death due to sodium sulfide, whether the mice were maintained under air or oxygen. Pretreatment with sodium nitrite, however, increased the acute intraperitoneal lethal dose for 50% survival of the group (LD50) of sodium sulfide 2.5 times. Neither oxygen, thiosulfate, nor the combination potentiated the protective effects of nitrite against sulfide poisoning. Antidotal effects of nitrite in acute sulfide poisoning were demonstrated in rats. The therapeutic efficacy of nitrite in acute poisoning is clearly superior to that of oxygen, which is the more widely recommended antidote.
Automatic source identification of monophonic musical instrument sounds (2002)

A system has been developed which automatically identifies the source of monophonic musical instrument sounds. Preprocessing of sound recordings includes calculation of the short term RMS energy envelope, principal component analysis and ratio/product transformations of the resultant principal components. An artificial neural network and a nearest neighbour classifier were compared to determine which one provided optimum classification ability. The system performance was tested on sounds recorded from four musical instruments chosen to represent each of the major musical instrument families and playing notes over the range of one octave under varying volume conditions. Classification accuracies in the range 93.8-100% were achieved.