gebhart/patrepeval huggingface dataset:
Role of Platelets in Tumor Cell Metastases (1981)

Platelets may have a role in the development of animal tumor metastases. Ultrastructural studies in vivo have shown arrested tumor emboli surrounded by platelets. Several tumor cell lines induce thrombocytopenia in vivo. Certain tumor cells aggregate platelets in vitro. Correlations exist between the ability of some tumor cells to aggregate platelets in vitro and their metastatic potential in vivo. Antiplatelet agents have impaired or altered the spread of certain tumor metastases. It is suggested that platelets have a role in the sequestration, adherence, and penetration of tumor cells through the blood vessel endothelial cell barrier, thus preventing their rapid clearance from the circulation and allowing extravascular formation of nests of cells. Antiplatelet agents, particularly prostaglandins, may prove useful in preventing experimental animal metastases when administered before the inoculation of tumor cells. Their potential in human malignancy, where the patient presents with an established tumor, remains to be established.
A Survey of Advance Reservation Routing and Wavelength Assignment in Wavelength-Routed WDM Networks (2011)

Traditionally, research on routing and wavelength assignment over wavelength-routed WDM networks is concerned with immediate reservation (IR) demands. An IR demand typically does not specify a holding time for data transmission and the start time of the data transmission is assumed to be immediate (i.e. when the connection request arrives). The concept of advance reservation (AR) has recently been gaining attention for optical networks. An AR demand typically specifies information about the start of the data transmission or a deadline, as well as the holding time of the transmission. AR has several important applications for both wide-area networks and Grid networks. For example, AR can be used for adjusting virtual topologies to adapt to predictable peak hour traffic usage. It can be used to provide high-bandwidth services such as video conferencing and in Grid applications requiring the scheduled distribution of large files and for co-allocation of network and grid resources. AR can also be beneficial to the network by allowing the network operator to better plan resource usage and therefore increase utilization. Knowledge of the holding time can lead to more optimal decisions for resource allocation. This translates to better quality of service for users. In this paper we provide a comprehensive survey of the past and current work on advance reservation for optical networks. There have been many variations of the advance reservation concept proposed, so we will also provide a broad classification. In addition to the survey, we will discuss what we believe are important areas of future work and open challenges for advance reservation on optical networks.
Acetylative cleavage of (arylsulfonyl)ureas to N-acetylarenesulfonamides and isocyanates (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcetylative cleavage of (arylsulfonyl)ureas to N-acetylarenesulfonamides and isocyanatesHerbert T. Nagasawa, William E. Smith, Chul Hoon Kwon, and David J. W. GoonCite this: J. Org. Chem. 1985, 50, 24, 4993–4996Publication Date (Print):November 1, 1985Publication History Published online1 May 2002Published inissue 1 November 1985https://pubs.acs.org/doi/10.1021/jo00224a077https://doi.org/10.1021/jo00224a077research-articleACS PublicationsRequest reuse permissionsArticle Views361Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Continuous scanning laser Doppler vibrometer for mode shape analysis (2003)

The vibration mode shape measurement technique utilizing a continuous scanning laser Doppler vibrometer (SLDV) is addressed. Continuous scanning capability is added to the conventional discrete laser Doppler vibrometer by reflecting the laser beam on the surface of the object using two oscillating mirrors. Bow scanning resulting from the proposed scanning mechanism is compensated by controlling the two mirrors. If a continuous sinusoidal scanning method is used, it can be shown that the velocity output signal from the SLDV is modulated to give the spatial velocity distribution in terms of coefficients that are obtained from the Fourier transformation of the time-dependent velocity signal. Using the Chebyshev series form, the analysis of vibration mode shape techniques for 2-D scanning is presented and discussed. The performance of the proposed SLDV is presented using the experimental results of the vibration mode shape of a plate.
Direct Binding and Characterization of Lipase onto Magnetic Nanoparticles (2003)

Lipase was covalently bound onto Fe(3)O(4) magnetic nanoparticles (12.7 nm) via carbodiimide activation. The Fe(3)O(4) magnetic nanoparticles were prepared by coprecipitating Fe(2+) and Fe(3+) ions in an ammonia solution and treating under hydrothermal conditions. The analyses of transmission electron microscopy (TEM) and X-ray diffraction (XRD) showed that the size and structure of magnetic nanoparticles had no significant changes after enzyme binding. Magnetic measurement revealed the resultant lipase-bound magnetic nanoparticles were superparamagnetic with a saturation magnetization of 61 emu/g (only slightly lower than that of the naked ones (64 emu/g)), a remanent magnetization of 1.0 emu/g, and a coercivity of 7.5 Oe. The analysis of Fourier transform infrared (FTIR) spectroscopy confirmed the binding of lipase onto magnetic nanoparticles. The binding efficiency of lipase was 100% when the weight ratio of lipase bound to Fe(3)O(4) nanoparticles was below 0.033. Compared to the free enzyme, the bound lipase exhibited a 1.41-fold enhanced activity, a 31-fold improved stability, and better tolerance to the variation of solution pH. For the hydrolysis of pNPP by bound lipase at pH 8, the activation energy within 20-35 degrees C was 6.4 kJ/mol, and the maximum specific activity and Michaelis constant at 25 degrees C were 1.07 micromol/min mg and 0.4 mM, respectively. It revealed that the available active sites of lipase and their affinity to substrate increased after being bound onto magnetic nanoparticles.
ACE: A Circuit Extractor (1983)

This paper describes the design, implementation and performance of a fiat edge-based circuit extractor for NMOS circuits. The extractor is able to work on large and complex designs, it can handle arbitrary geometry, and outputs a comprehensive wirelist. Measurements show that the run time of the edge-based algorithm used is linear in size of the circuit, with low implementation overheads. The extractor is capable of analyzing a circuit with 20,000 transistors in less than 30 minutes of CPU time on a VAX 11/780. The high performance of the extractor has changed the role that a circuit extractor played in the design process, as it is now possible to extract a chip a number of times during the same session.
MU2A—reconciling the genome and transcriptome to determine the effects of base substitutions (2010)

Next-generation sequencing technologies enable the identification of sequence variation in the genome and transcriptome. Differences between the reference genome and transcript libraries complicate the determination of the effect of genomic sequence variants on protein products; similarly, these differences complicate the mapping of sequence variants found in transcripts to their respective genomic position. We have developed MU2A, a publicly available web service for variant annotation that reconciles differences between the genome and transcriptome, enabling the rapid and accurate determination of the effects of genomic variants on protein products, and the mapping of variants detected in transcripts to genomic coordinates. The MU2A web service is available at http://krauthammerlab.med.yale.edu/mu2a. We have released MU2A as open source, available at http://code.google.com/p/mu2a/.
Surface enhanced ellipsometric contrast (SEEC) basic theory and λ/4 multilayered solutions (2007)

The fundamentals of a new high contrast technique for optical microscopy, named "Surface Enhanced Ellipsometric Contrast" (SEEC), are presented. The technique is based on the association of enhancing contrast surfaces as sample stages and microscope observation between cross polarizers. The surfaces are designed to become anti-reflecting when used in these conditions. They are defined by the simple equation r(p) + r(s) = 0 between their two Fresnel coefficients. Most often, this equation can be met by covering a solid surface with a single lambda/4 layer with a well defined refractive index. A higher flexibility is obtained with multilayer stacks. Solutions with an arbitrary number of all-dielectric lambda/4 layers are derived.
Fast, real-time monitoring of rotating machines using digital motion control coprocessors (2003)

This paper describes the use of methods and techniques that have been developed for high-performance control of relatively small and slow turning industrial machines and extend these techniques to the more demanding regime of AC machines used for kinetic energy storage and fast AC servos for military applications. In particular this paper describes a technique for fast monitoring of the output voltage of AC generators. To accomplish fast monitoring, the (sinusoidal) AC output voltage is converted to a DC quantity that represents the instantaneous amplitude. This is achieved through the use of a rotational transformation. This transformation, also called "vector rotation," can be used for very fast observation of the momentary amplitudes of all electrical machine quantities, such that averaging of the AC value (to determine "momentary average" rms amplitude) is not necessary. The procedure is implemented by tightly integrating a digital motion control coprocessor into the memory map of a 16-bit microcontroller.
Plasma-Enhanced Atomic Layer Deposition of Silver Thin Films (2011)

Thermal properties of various silver precursors known in the literature were evaluated in order to discover which precursor is the most suitable one for plasma-enhanced atomic layer deposition (PEALD) of silver thin films. Ag(fod)(PEt3) (fod = 2,2-dimethyl-6,6,7,7,8,8,8-heptafluorooctane-3,5-dionato) was found to be the best choice. Using Ag(fod)(PEt3) together with plasma-activated hydrogen, silver thin films were deposited at growth temperatures of 120–150 °C, and ALD-type saturative growth was achieved at 120–140 °C. At 120 °C, the growth rate was 0.03 nm per cycle. The plasma exposure time had also an effect on the growth rate: with shorter exposure times, the growth rate was lower over the whole deposition area. The films deposited at 120 °C contained relatively small amounts of impurities, but these still affected the electrical properties of the films. The resistivities were relatively low: about 20 nm thick films had a resistivity of 6–8 μΩ·cm. The morphology and the crystal structure of the films were analyzed as well.
Detachment of Descemet's membrane from grafts following wound separation: light and scanning electron microscopic study. (1975)

Examination of 4 specimens of failed grafts following wound rupture shows that separation of Descement's membrane from the periphery of the graft in the area of dehiscence is followed by morphological changes in endotelial cells and by the development of fibrous membranes. Defective wound healing after repair is probably caused by persistent edema of graft stroma. With sudden decompression of the globe, rupture and total detachment of Descemet's membrane may occur. Changes in Descemet's membrane and eventual failure of the graft may occur mostly on the basis of anatomical changes in the endothelium of the graft and not necessarily by inflammation which was not present in these 4 specimens.
E-Tax Invoice System Using Web Services Technology: A Case Study of the Revenue Department of Thailand (2008)

This research project proposed an "e-Tax Invoice System" using Web Services (WS) technology for the Revenue Department of Thailand (RD). This system uses four WS technologies namely XML, WSDL, UDDI and SOAP, hence the system is able to communicate with several applications on heterogeneous platforms. In addition, the proposed e-Tax Invoice System applies two security technologies: SSL as a secure channel for data exchange and Hash Function for transforming a plain password into an unreadable password. The proposed system is able to collect tax invoice data from taxpayers especially Business. Through the system, Business can send tax invoice data immediately to the RD once the payment occurs. Therefore, the proposed system can provide up-to-date data to generating reports for the RD Official. The report can help improve the RDpsilas work processes especially tax payment auditing. Moreover, the proposed system allows Customer and Business to search tax invoice data online. The research also performed comparative analysis which indicates that the e-Tax Invoice System can solve problems in the current system and enhance the RDpsilas work processes concerning the tax invoice systems.
Ubiquitinylation Is Not an Absolute Requirement for Degradation of c-Jun Protein by the 26 S Proteasome (1995)

Degradation of rapidly turned over cellular proteins is commonly thought to be energy dependent, to require tagging of protein substrates by multi-ubiquitin chains, and to involve the 26 S proteasome, which is the major neutral proteolytic activity in both the cytosol and the nucleus. The c-Jun oncoprotein is very unstable in vivo. Using cell-free degradation assays, we show that ubiquitinylation, along with other types of tagging, is not an absolute prerequisite for ATP-dependent degradation of c-Jun by the 26 S proteasome. This indicates that a protein may bear intrinsic structural determinants allowing its selective recognition and breakdown by the 26 S proteasome. Moreover, taken together with observations by different groups, our data point to the notion of the existence of multiple degradation pathways operating on c-Jun.
Flutter simulations of a T‐tail configuration using non‐linear aerodynamics (2007)

Abstract A numerical flutter simulation of a T‐tail configuration in the transonic region is presented. A code for aeroelastic simulations based on the multi‐block and overset grid concept was developed and has been applied to a T‐tail configuration. Flutter simulations are performed at Mach numbers in the range 0.70–0.95, and the obtained results correspond to experimental results. The effect of varying the angle of attack on the flutter boundary is also presented. Copyright © 2007 John Wiley & Sons, Ltd.
<b>AUTORADIOGRAPHIC EVIDENCE OF ANGIOTENSIN II BINDING SITES IN THE HUMAN ADRENAL </b><b>GLAND </b> (1988)

Angiotensin II binding sites in human adrenal glands obtained at autopsy were investigated. The tissue sections were incubated with 125I-angiotensin II and analyzed using [3H]-Ultrofilm autoradiography with image analysis coupled to computerized microdensitometry. In addition, a comparison was made with 125I-standards. A single type of specific, high affinity binding sites was found in the zona glomerulosa and medulla. The rank order for inhibition of the binding in the zona glomerulosa and medulla was [Sar1, Ile8]-angiotensin II and Des-Asp1-[Ile8]angiotensin II > native angiotensin II = angiotensin III >>> angiotensin I, αhuman atrial natriuretic polypeptide (ANP-(99-126)), substance P and methionineenkephalin. The possibility that angiotensin II plays a significant role in function of the human adrenal zona glomerulosa and medulla by interacting with specific, high affinity receptors, Warrants further attention.
A Statistical Analysis of Telephone Circuit Error Data (1966)

Berger and Mandelbrot in 1963 proposed a particular renewal process as a model for the occurrence of errors in data transmitted over telephone circuits. Besides the assumed independence between the successive intervals between errors, they assume that the intervals have a Pareto distribution. Their graphical analyses of large amounts of data indicated departures from the model which Mandelbrot proposed in 1964 to account for in an extended model. Some simple formal statistical procedures are given for analyzing this sort of data, procedures that are not affected by the possibility that the population mean-interval-between-errors is infinite. The departures from independence of intervals noted by Berger and Mandelbrot are formally verified from the analysis of data from a single data transmission test. A separate analysis of another set of data is also made and the results are compared to see what features of the error patterns are general, and what features are particular to different transmission conditions. In both sets of data analyzed, the outstanding feature detected is the strong positive correlation between successive long intervals between errors. Evidence is also found which indicates that the upper tail of the marginal distribution of intervals between errors does not follow a hyperbolic law.
Chronology of Fabry-Perot Interferometer Fiber-Optic Sensors and Their Applications: A Review (2014)

Optical fibers have been involved in the area of sensing applications for more than four decades. Moreover, interferometric optical fiber sensors have attracted broad interest for their prospective applications in sensing temperature, refractive index, strain measurement, pressure, acoustic wave, vibration, magnetic field, and voltage. During this time, numerous types of interferometers have been developed such as Fabry-Perot, Michelson, Mach-Zehnder, Sagnac Fiber, and Common-path interferometers. Fabry-Perot interferometer (FPI) fiber-optic sensors have been extensively investigated for their exceedingly effective, simple fabrication as well as low cost aspects. In this study, a wide variety of FPI sensors are reviewed in terms of fabrication methods, principle of operation and their sensing applications. The chronology of the development of FPI sensors and their implementation in various applications are discussed.
Internal quantum efficiency of laser diodes (1992)

The internal quantum efficiency of laser diodes is determined from a consideration of current flow at threshold, and the corresponding quasi-Fermi level separation is used to evaluate the magnitude of all current components. The internal quantum efficiency is shown to be a strong function of temperature and cavity length. The results for single, multiple and strained quantum well structures are compared.
Optimal SHE-PWM switching patterns for an HVDC system built with eight conventional three-phase VSC modules (2008)

This paper discusses optimal selective harmonic elimination (SHE) pulse-width modulation (PWM) patterns derived from a pre-calculated 9-level waveform. The patterns are suitable for a high-voltage direct-current (HVDC) power transmission system based on eight conventional three-phase voltage-source converter (VSC) modules. The switching frequency of each module is maintained very low and is used as a measure to derive the optimal patterns. Both the switching losses of each module and of the overall HVDC system are kept to a minimum level. The theoretical findings are verified through simulation studies using PSCAD/EMTDC and results are presented in the paper to confirm the effectiveness of the proposed approach.
P66<sup>ShcA</sup> interacts with MAPKAP kinase 2 and regulates its activity (2004)

Three mitogen activated protein kinase-activated protein kinase 2 (MAPKAP kinase 2, MK2) interacting proteins were identified using a yeast two-hybrid approach. ShcA, a signaling phospho-protein, human polyhomeotic 2 (HPH2), a transcriptional regulator, and highly similar to smoothelin (HSTS), which is related to the cytoskeletal associated protein smoothelin, interact specifically with MK2. The interaction of MK2 with the 66 kDa isoform of ShcA, p66(ShcA), and HPH2 was confirmed using co-immunoprecipitation. MK2 is activated with p66(ShcA) co-expression and p66(ShcA) is an in vitro substrate for MK2, further demonstrating their association and suggesting a biological role for p66(Shc) in MK2 activation.
Neural network models of the tactile system develop first-order units with spatially complex receptive fields (2017)

Abstract First-order tactile neurons have spatially complex receptive fields. Here we use machine learning tools to show that such complexity arises for a wide range of training sets and network architectures, and benefits network performance, especially on more difficult tasks and in the presence of noise. Our work suggests that spatially complex receptive fields are normatively good given the biological constraints of the tactile periphery.
Designing a coprocessor for recurrent computations (2002)

We present the design of an application-specific coprocessor for algorithms that can be modeled as uniform recurrences or "uniformized" affine recurrences. The coprocessor has a regular array of processors connected to an access-unit for intermediate storage of data. The distinguishing feature of our approach is that we assume the coprocessor to be interfaced to a standard, slow (single-ported) memory with low bandwidth. Hence, good performance is achieved by effectively exploiting data locality in the applications by the compiler, and the final architecture is chosen by a tradeoff analysis driven by the mapping process. Preliminary results indicate that the coprocessor has significantly lower clock rates or higher performance than that of existing RISC processors and is cost-effective for executing loop computations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Antiproliferative Activity of Human Interferons Against Ovarian Cancer Cells Grown in Human Tumor Stem Cell Assay (1984)

Fresh biopsies from 14 of 22 (64%) ovarian carcinomas cultivated in the human tumor stem cell assay (HTSCA) were sensitive (greater than 70% inhibition in cell growth) to human interferons (HuIFNs). To achieve 70% inhibition of colony growth, 500 units/ml of a naturally produced IFN-alpha or IFN-alpha A were required in 71% of the sensitive specimens. The antiproliferative potencies of five IFNs were evaluated including two native alpha IFNs, two highly purified cloned subtypes of IFN-alpha, IFN-alpha D and IFN-alpha A, and one native fibroblast-derived beta interferon (IFN-beta). The antiviral activity of the IFN-alpha as determined by a human cell target correlated with their relative antiproliferative action. IFN-alpha D had minimal inhibitory effect at the highest concentration tested, while three IFN-alpha with high antiviral activities were equivalent with respect to growth inhibition in the HTSCA. Although instability could not be eliminated as a contributing factor, IFN-beta had significantly less growth inhibitory potency for cells from ovarian cancers when compared simultaneously with native IFN-alpha in the human tumor stem cell assay (HTSCA). Assuming direct antiproliferative effects are primary, future clinical trials evaluating IFN-alpha in ovarian cancer may require high titers of IFN.