gebhart/patrepeval huggingface dataset:
Action phases and mind-sets (1990)

The focus of this chapter is on the course of action, which is understood to be a temporal, horizontal path starting with a person's desires and ending with the evaluation of the achieved action outcome. The phenomena of choosing an action goal, initiating the appropriate actions, and executing these actions are assumed to be situated in between. This comprehensive perspective conceives of the course of action as a number of consecutive, distinct segments or phases. It raises questions concerning how people choose action goals, plan and enact their execution, and eaaluate thek efforts. The concept of mind-set is employed to find answers to these questions in terms of the cognitive processes or orientations that allow for easy completion of the different action phases.
WRS-85D: A Tryptophanyl-tRNA Synthetase Expressed to High Levels in the Developing<i>Drosophila</i>Salivary Gland (1999)

In a screen for genes expressed in the Drosophila embryonic salivary gland, we identified a tryptophanyl-tRNA synthetase gene that maps to cytological position 85D (WRS-85D). WRS-85D expression is dependent on the homeotic gene Sex combs reduced (Scr). In the absence of Scr function, WRS-85D expression is lost in the salivary gland primordia; conversely, ectopic expression of Scr results in expression of WRS-85D in new locations. Despite the fact that WRS-85D is a housekeeping gene essential for protein synthesis, we detected both WRS-85D mRNA and protein at elevated levels in the developing salivary gland. WRS-85D is required for embryonic survival; embryos lacking the maternal contribution were unrecoverable, whereas larvae lacking the zygotic component died during the third instar larval stage. We showed that recombinant WRS-85D protein specifically charges tRNATrp, and WRS-85D is likely to be the only tryptophanyl-tRNA synthetase gene in Drosophila. We characterized the expression patterns of all 20 aminoacyl-tRNA synthetases and found that of the four aminoacyl-tRNA synthetase genes expressed at elevated levels in the salivary gland primordia, WRS-85D is expressed at the highest level throughout embryogenesis. We also discuss the potential noncanonical activities of tryptophanyl-tRNA synthetase in immune response and regulation of cell growth.
Oxidative Modification of Low-Density Lipoprotein and Atherogenetic Risk in β-Thalassemia (1998)

We investigated the oxidative state of low-density lipoprotein (LDL) in patients with β-thalassemia to determine whether there was an association with atherogenesis. Conjugated diene lipid hydroperoxides (CD) and the level of major lipid antioxidants in LDL, as well as modified LDL protein, were evaluated in 35 β-thalassemia intermedia patients, aged 10 to 60, and compared with age-matched healthy controls. Vitamin E and β-carotene levels in LDL from patients were 45% and 24% of that observed in healthy controls, respectively. In contrast, the mean amount of LDL-CD was threefold higher and lysil residues of apo B-100 were decreased by 17%. LDL-CD in thalassemia patients showed a strong inverse correlation with LDL vitamin E (r = −0.784; P < .0001), while a negative trend was observed with LDL-β–carotene (r = −0.443; P = .149). In the plasma of thalassemia patients, malondialdehyde (MDA), a byproduct of lipid peroxidation, was increased by about twofold, while vitamin E showed a 52% decrease versus healthy controls. LDL-CD were inversely correlated with plasma vitamin E (r = −0.659; P < .0001) and correlated positively with plasma MDA (r = 0.621; P < .0001). Plasma ferritin was positively correlated with LDL-CD (r = 0.583; P =.0002). No correlation was found between the age of the patients and plasma MDA or LDL-CD. The LDL from thalassemia patients was cytotoxic to cultured human fibroblasts and cytotoxicity increased with the content of lipid peroxidation products. Clinical evidence of mild to severe vascular complications in nine of the patients was then matched with levels of LDL-CD, which were 36% to 118% higher than the mean levels of the patients. Our results could account for the incidence of atherogenic vascular diseases often reported in β-thalassemia patients. We suggest that the level of plasma MDA in β-thalassemia patients may represent a sensitive index of the oxidative status of LDL in vivo and of its potential atherogenicity.
Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review (2018)

Wound healing is a well-tuned biological process, which is achieved via consecutive and overlapping phases including hemostasis, inflammatory-related events, cell proliferation and tissue remodeling. Several factors can impair wound healing such as oxygenation defects, aging, and stress as well as deleterious health conditions such as infection, diabetes, alcohol overuse, smoking and impaired nutritional status. Growing evidence suggests that reactive oxygen species (ROS) are crucial regulators of several phases of healing processes. ROS are centrally involved in all wound healing processes as low concentrations of ROS generation are required for the fight against invading microorganisms and cell survival signaling. Excessive production of ROS or impaired ROS detoxification causes oxidative damage, which is the main cause of non-healing chronic wounds. In this context, experimental and clinical studies have revealed that antioxidant and anti-inflammatory strategies have proven beneficial in the non-healing state. Among available antioxidant strategies, treatments using mitochondrial-targeted antioxidants are of particular interest. Specifically, mitochondrial-targeted peptides such as elamipretide have the potential to mitigate mitochondrial dysfunction and aberrant inflammatory response through activation of nucleotide-binding oligomerization domain (NOD)-like family receptors, such as the pyrin domain containing 3 (NLRP3) inflammasome, nuclear factor-kappa B (NF-κB) signaling pathway inhibition, and nuclear factor (erythroid-derived 2)-like 2 (Nrf2).
Michael reaction of acrylate salts (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMichael reaction of acrylate saltsHenry E. Fritz, David W. Peck, and Kenneth E. AtkinsCite this: J. Org. Chem. 1968, 33, 6, 2577–2580Publication Date (Print):June 1, 1968Publication History Published online1 May 2002Published inissue 1 June 1968https://pubs.acs.org/doi/10.1021/jo01270a112https://doi.org/10.1021/jo01270a112research-articleACS PublicationsRequest reuse permissionsArticle Views160Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterization of Signals Promoting Gene Expression on the <i>Staphylococcus aureus</i> Plasmid pUB110 and Development of a Gram-Positive Expression Vector System (1986)

The transcriptional and translational initiation signals of a portion of the Staphylococcus aureus plasmid pUB110 were analyzed. An Mbo I-Pvu II fragment was sequenced and the site of transcriptional initiation was determined by in vitro mapping. To convert the plasmid into a cloning vector, a multilinker was introduced in different positions relative to a detected reading frame. The Gram-negative beta-galactosidase gene and the Gram-positive chloramphenicol acetyltransferase (cat) gene were fused and the level of expression was determined in Bacillus subtilis. Hybrid proteins consisting of corresponding CAT polypeptides were produced in each translational reading frame. Therefore this vector system can be used to express cloned DNA in the Gram-positive host Bacillus subtilis. Furthermore a derived lacZ fusion plasmid may be used for rapid screening of inserts.
The Sunflower Spiral and the Fibonacci Metric (2010)

The sunflower spiral is a well known and attractive pattern often seen in the arrangement of leaves or other features in plants (phyllotaxis), with close connections to the Fibonacci sequence. We describe an interesting colouring of the points of the sunflower spiral, involving a “metric ” on the positive integers which counts the number of distinct non-consecutive Fibonacci numbers needed to sum to a given number. We also explain some initially surprising features of the resulting coloured pattern.
THE EFFECT OF PHYSICIAN'S ADVICE ON ADOLESCENT EXERCISE BEHAVIOR AND FITNESS (1998)

551 To evaluate the advice of an office-based physician as a mean of increasing fitness in adolescent patients (12 to 21 years old), something that has not been proved as yet: patients were randomly asigned to a case or a control group matched by sex and age, after visiting the offices of 3 different physicians for a period of 6 months. Both groups were given a questionnaire recording exercise (type, duration (D), frequency (F) and intensity (I) at and outside school and the following measurements were taken: resting blood pressure (RBP) and heart rate (RHR), percent body fat (PBF), flexibility (FX)(“sit and reach” test), strength (ST) (handgrip dinamometry) and cardiorespiratory endurance (CRE) (modified step test). Cases were provided with counseling to maintain (active adolescents), increase (partially active adolescents) or start (inactive adolescents) exercise at the first and six months visits. Questionnaires and measurements were again evaluated after 12 months. A sample of 94 cases and 94 controls (63% males and 37% females) was gathered. At the first visit, there were 36,2% active adolescents in both groups, with no significant differences in fitness measurements between groups. At 12 months, cases had increased the number of active adolescents(43%; p<0,01) and ST (28 to 31 units; p<0,01) and decreased RBP (113/68 to 110/65 mmHg; p<0,01) and PBF (18% to 17%; p<0,04), whereas controls had decreased the number of active adolescents (31%; p<0,01) and increased RHR (71 to 74 bpm; p<0,03) and ST (29 to 30 units; p<0,03). However, there were no significant differences between the groups. Cases significantly increased only in F (1,7 to 2,3 days/week; p<0,02) and in spite of increasing also D and I, and controls decreasing D, F and I, there were important differences at 12 months but they did not reach statistic significance. Physician counseling about exercise was followed by 52% of adolescents cases. Based-office physician's advice about exercise to adolescent patients is of use to increase their exercise levels to a degree resulting in short fitness improvement after a year.
From Real Time Data to Production Optimization (2004)

Abstract A new way of reservoir management is dawning at the horizon – intelligent reservoir management utilizing continuous data from intelligent wells and/or smart fields. Even though there are many different buzz words for this new technology, they all lead to the same – managing a reservoir in REAL TIME or close to REAL TIME. Real time usually means to react to an event as it happens or within a short time lag. In the petroleum industry real time is for sure different. This "short time lag" can be hours, days or even weeks, which of course depends highly on the objective itself. Integrating real-time data into a reservoir management work flow and turn the data into value is a complex task. The bottle neck for the data flow right now is the transfer of the real time data - measured with a secondly and minutely time increment and stored on real time server – to the engineers’ desktops in a clean and timely useful fashion. This paper will show ways how to provide a continuous (24/7) flow of clean data to the engineers’ desktop as a first step for the intelligent reservoir management. It will be shown that the implementation of a smart field rises or falls with the ability to provide the data to the knowledge worker – the petroleum engineer. Since the data is coming into the database, let’s say every hour or every other day, the engineer is not able to check this data for discrepancies. Therefore, intelligent reservoir management needs an alarm system to inform the engineers about any under performing or critical condition of a well or the reservoir itself. Another important aspect is the integration of the standard petroleum engineering tools, like Decline Curve Analysis, Material Balance, IPR curves, Reservoir Simulation, etc., into this work process. Now an Inflow Performance Relationship Curve does not only get data every other month, but every other day. This gives the engineer completely new opportunities, e.g. monitoring the permeability impairment over time. Well tests are usually a snapshot in time, but with a continuous surveillance of the reservoir parameters, the development of, e.g., the skin can be followed over time and actions can be taken in time – predictive maintenance. Neural Networks and Genetic Algorithms are other powerful tools in the real time environment, handling such a large amount of data. A Neural Network learns on the gathered data and detects their underlying relationships – the more data, the better. Afterwards, the Neural Networks can be used for predictions (predictive data mining) – for instance predicting sand production. This approach gives the engineer time to react, and prevents the equipment from harm. This work and the methodology it implies, provides a straight forward way of integrating real time data into a reservoir management process and how to gain value from the information provided by a continuous data stream.
Validating discrete event simulations using event pattern mappings (1992)

The authors introduce a new concept for the validation of discrete event simulations, based on recursively detecting and naming patterns of events. In this methodology, simulation results are presented as a small set of easy-to-understand high-level events. This hierarchical presentation of simulation results greatly reduces the designer's work in browsing through simulation results and detecting errors. Language constructs are introduced for defining event patterns that are VAL+ mappings. A software tool based on mappings is described and results of using the debugger on three large examples are included. >
Application of an <i>in vitro</i> assay for serum thymidine kinase: Results on viral disease and malignancies in humans (1984)

Abstract An improved method for the detection of deoxythymidine kinase (TK) in human sera is reported. The method which utilizes 125 I‐iododeoxyuridine (IdUrd) as a substrate was used to measure TK in sera from patients with different diseases. Sera collected during the acute stage of infectious mononucleosis were found to contain elevated levels of TK, in most cases 10–40 times the normal value. The serum TK activity disappeared gradually and reached a normal level within 4 weeks. Sera from patients with other viral infections contained in most cases normal serum TK levels except in connection with measles, rubella, varicella, herpes simplex virus and cytomegalovirus infections. Additional studies revealed that sera from patients with different types of advanced lymphomas, acute leukemias, chronic granulocytic leukemia and lung cancer of the small‐cell type with metastases, contained high TK level which fluctuated in parallel with alterations in activity of the disease. The TK activity in sera from patients with both mononucleosis and tumor disease was characterized by electrophoresis and by its ability to utilize cytidine triphosphate as the phosphate donor. The results showed that the serum TK has the same properties as the human cytosolar TK1, except in connection with varicella.
The Pseudokinase Domain Is Required for Suppression of Basal Activity of Jak2 and Jak3 Tyrosine Kinases and for Cytokine-inducible Activation of Signal Transduction (2002)

Janus (Jak) tyrosine kinases contain a tyrosine kinase (JH1) domain adjacent to a catalytically inactive pseudokinase domain (JH2). The JH2 domain has been implicated in regulation of Jak activity, but its function remains poorly understood. Here, we found that the JH2 domain negatively regulates the activity of Jak2 and Jak3. Deletion of JH2 resulted in increased tyrosine phosphorylation of the Jak2- and Jak3-JH2 deletion mutants as well as of coexpressed STAT5. In cytokine receptor signaling, the deletion of the Jak2- and Jak3-JH2 domains resulted in interferon-gamma and interleukin-2-independent STAT activation, respectively. However, cytokine stimulations did not further induce the JH2 deletion mutant-mediated STAT activation. The deletion of the Jak2 JH2 domain also abolished interferon-gamma-inducible kinase activation, although it did not affect the reciprocal Jak1-Jak2 interaction in 293T cells. Chimeric constructs, where the JH2 domains were swapped between Jak2 and Jak3, retained low basal activity and cytokine inducible signaling, indicating functional conservation between the two JH2 domains. However, the basal activity of Jak2 was significantly lower than that of Jak3, suggesting differences in the regulation of Jak2 and Jak3 activity. In conclusion, we found that the JH2 domain has a conserved function in Jak2 and Jak3. The JH2 domain is required for two distinct functions in cytokine signaling: (i) inhibition of the basal activity of Jak2 and Jak3, and (ii) cytokine-inducible activation of signaling. The Jak-JH2 deletion mutants are catalytically active, activate STAT5, and interact with another Jak kinase, but the JH2 domain is required to connect these signaling events to receptor activation. Thus, we propose that the JH2 domain contributes to both the uninduced and ligand-induced Jak-receptor complex, where it acts as a cytokine-inducible switch to regulate signal transduction.
Comparison of Cellular Accumulation, Tissue Distribution, and Anti-HIV Activity of Free and Liposomal 2′,3′-Dideoxycytidine (1994)

We have investigated the cellular accumulation, tissue distribution, and antihuman immunodeficiency virus activity of free dideoxycytidine (ddC) and liposomal ddC (L-ddC). We have found that L-ddC was more efficiently taken up than its free form by RAW 264.7 cells (a monocyte-macrophage cell line) (p < 0.01) while a comparable uptake was seen in U937 cells (a promonocytic cell line). In the rat, L-ddC accumulated preferentially in liver and spleen when injected intravenously (p < 0.01), and mostly in spleen when given intraperitoneally (p < 0.01). In contrast, free ddC was rapidly eliminated out of the body. Liposomal ddC showed a similar anti-HIV activity in comparison with free ddC in U937 cells. Given the fact that encapsulation of ddC in liposomes does not affect its anti-HIV activity but enhances its in vitro cellular accumulation and its in vivo distribution in reticuloendothelial system (RES) tissues, we conclude that ddC in liposomal formulation is a promising anti-HIV agent with a targeted action on the RES, which is considered a reservoir for dissemination of virus to other cells, tissues, and organs.
Can we surgically remove swell noise? (1995)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1995Can we surgically remove swell noise?Authors: Guillaume CamboisJacques FreletGuillaume CamboisCGG, France and Jacques FreletCGG, Francehttps://doi.org/10.1190/1.1887228 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1887228FiguresReferencesRelatedDetailsCited ByRobust f - x projection filtering for simultaneous random and erratic seismic noise attenuation25 August 2016 | Geophysical Prospecting, Vol. 65, No. 3Seismic velocity analysis method based on chaotic systemBo Wang, Yang Liu, and Cai Liu5 August 2014High-amplitude noise detection by the expectation-maximization algorithm with application to swell-noise attenuationMaïza Bekara and Mirko van der Baan26 May 2010 | GEOPHYSICS, Vol. 75, No. 3 SEG Technical Program Expanded Abstracts 1995ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1995 Pages: 1566 publication data© 1995 Copyright © 1995 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Guillaume Cambois and Jacques Frelet, (1995), "Can we surgically remove swell noise?," SEG Technical Program Expanded Abstracts : 1381-1384. https://doi.org/10.1190/1.1887228 Plain-Language Summary PDF DownloadLoading ...
FINITE ELEMENT PROCEDURES FOR FATIGUE ASSESSMENT OF SHIP STRUCTURAL DETAILS (2003)

The design of welded structures is mostly based on guidelines and rules,\nsuggesting simplified procedures based on tests carried out on standard\nstructural details. Such S-N curves procedures are a practical tool for the\nevaluation of the fatigue strength of a ship structural detail. The basic\nassumption of them is that the captioned detail has the same fatigue behavior of\na class of standard details. The reference structural details presented by the\nguidelines are necessarily limited. From this point of view designers are\nimplicitly driven to use mainly standard structural solutions.\nA way to generalize fatigue strength assessment is the adoption of a local\napproach, which requires the determination of the stresses in way of the crack\nstarting location to be compared with their critical value at a given cycles\nnumber.\nIn this paper different finite element techniques have been used and\ncompared in evaluating the stress concentration factors. A calibration of finite\nelement techniques is achieved involving knowledge of parameters sensitivity\nbased on the experimental results of a typical ship structural detail tested in the\nShip Structures Laboratory of DINAV.
Volatility in Tax-Exempt Bonds: A Theoretical Model (1981)

(1981). Volatility in Tax-Exempt Bonds: A Theoretical Model. Financial Analysts Journal: Vol. 37, No. 6, pp. 31-52.
Fetal pulse oximetry (1998)

Within the last ten years several groups adapted pulse oximetry to be used in the fetus. The obvious advantage of this technology is the fact that a biochemical parameter--the arterial oxygen saturation--can be measured continuously during delivery. Nevertheless, the continuous information about the fetal oxygenation during delivery has a couple of obstacles to surmount. It is well known that fetal reflectance pulse oximetry may be influenced by a number of artifacts. In addition, severe physiological considerations should remind us of the limited diagnostic value of saturation monitoring alone in order to predict fetal acidosis. Some recent articles deal with the predictive value of fetal pulse oximetry for fetal compromise. While it appears that the fetal wellbeing is more likely to be in accordance with a normal saturation measured by current pulse oximetry systems, the number of fetuses detected by pulse oximetry suffering from hypoxia seems to be low. Different authors describe a poor sensitivity to predict fetal compromise. One reason therefore may be the reduced precision of the oxysensor in the low saturation range. Therefore, we conclude that the current generation of fetal pulse oximetry sensors is not improving the quality of combined fetal monitoring of fetal heart rate and fetal scalp blood analysis.