gebhart/patrepeval huggingface dataset:
Production of Gamma-Linolenic Acid in Pichia pastoris by Expression of a Delta-6 Desaturase Gene from Cunninghamella echinulata (2009)

Gamma-linolenic acid (GLA, C18:3 delta(6,9,12)) is synthesized by a delta-6 fatty acid desaturase using linoleic acid (LA, C18:2 delta(9,12)) as a substrate. To enable the production of GLA in the conventional yeast Pichia pastoris, we have isolated a cDNA encoding the delta-6 fatty acid desaturase from Cunninghamella echinulata MIAN6 and confirmed its function by heterogeneous expression in P. pastoris. Sequence analysis indicated that this cDNA sequence has an open reading frame of 1,404 bp, which encodes a 52 kDa peptide of 468 amino acids. This sequence has 64% identity to the previously reported delta-6 fatty acid desaturase from Rhizopus oryzae. The polypeptide has a cytochrome b5 domain at the N-terminus including the HPGG motif in the heme-binding region, as reported for other delta-6 fatty acid desaturases. In addition, this enzyme differs from other desaturases by the presence of three possible N-linked glycosylation sites. Analysis of the fatty acid composition demonstrated the accumulation of GLA to the level of 3.1% of the total fatty acids. Notably, the amounts of ginkgolic acid (C17:1) and palmitic acid (C16:0) were increased from 1.3% to 29.6% and from 15% to 33%, respectively. These results reveal that the modification of the fatty acid biosynthetic pathway by genetic manipulation in order to produce specific polyunsaturated fatty acids in P. pastoris is a promising technique.
Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma. (2003)

Expression profiling has demonstrated that transcriptomes of primary malignancies differ from those in normal tissue. It is unknown, however, whether there exist "surrogate" transcriptional markers in peripheral blood mononuclear cells (PBMCs) of patients with solid tumors. We identified transcripts expressed differentially between PBMCs from renal cell carcinoma patients and normal subjects, some of which appear to reflect specific immune responses of circulating cells. We also identified small sets of predictor genes distinguishing PBMCs from renal cell carcinoma patients and normal volunteers with high accuracy. The present findings have important implications for diagnosis and future clinical pharmacogenomic studies of antitumor therapies.
Risk contributions and performance measurement (2000)

Risk adjusted performance measurement for a portfolio involves calculating the risk contribution of each single asset. We show that there is only one definition for the risk contributions which is suitable for performance measurement, namely as derivative of the underlying risk measure in direction of the considered asset. We also compute the derivatives for some popular risk measures including the quantile-based value at risk (VaR) in a rather general context. As a consequence we obtain a mean-quantile CAPM. Keywords: Performance measurement, portfolio selection, value at risk (VaR), quantile, shortfall, capital asset pricing model (CAPM).
Creation of a Monomeric Ru Species on the Surface of Hydroxyapatite as an Efficient Heterogeneous Catalyst for Aerobic Alcohol Oxidation (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTCreation of a Monomeric Ru Species on the Surface of Hydroxyapatite as an Efficient Heterogeneous Catalyst for Aerobic Alcohol OxidationKazuya Yamaguchi, Kohsuke Mori, Tomoo Mizugaki, Kohki Ebitani, and Kiyotomi KanedaView Author Information Department of Chemical Science and Engineering Graduate School of Engineering Science Osaka University, 1-3 Machikaneyama Toyonaka, Osaka 560-8531, Japan Cite this: J. Am. Chem. Soc. 2000, 122, 29, 7144–7145Publication Date (Web):July 11, 2000Publication History Received17 April 2000Published online11 July 2000Published inissue 26 July 2000https://pubs.acs.org/doi/10.1021/ja001325ihttps://doi.org/10.1021/ja001325irapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views5272Altmetric-Citations405LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Catalysts,Heterogeneous catalysts,Oxidation,Pharmaceuticals Get e-Alerts
Strongly anisotropic media: the THz perspectives of left-handed materials (2005)

We demonstrate that non-magnetic (μ≡1) left-handed materials can be effectively used for waveguide imaging systems. We also propose a specific THz realization of a non-magnetic left-handed material based on homogeneous, naturally occurring media.
Traps and Trapping Techniques for Adult Mosquito Control (2006)

An overview is presented of the recent advancements in research activities conducted to evaluate mosquito traps, insecticide-impregnated targets baited with combinations of attractants, and strategies for using mass trapping techniques for adult mosquito population management. Technologies that use semiochemicals (attractants), traps and targets, and mass trapping are relatively new for management of adult mosquito populations. To date, emphasis has been placed primarily on developing barriers of attractant-baited and insecticide-impregnated targets. The most successful continuous use of this type of technology has been at Stevens' Landing, Collier County, Florida. Recently, commercially available traps have been evaluated for their ability to reduce nuisance populations of mosquitoes. Whereas use of Mosquito Magnet Pro (MM-Pro) traps along a nature trail on an isolated island (Atsena Otie) in the Gulf of Mexico resulted in a significant reduction in annoyance caused by the black salt-marsh mosquito, Ochlerotatus taeniorhynchus (Wied.), a perimeter of the same traps did not result in the same level of mosquito reduction in a residential area in Gainesville, FL.
Hydrogenolysis of glycerol to 1,2‐propanediol catalyzed by Cu‐H<sub>4</sub>SiW<sub>12</sub>O<sub>40</sub>/Al<sub>2</sub>O<sub>3</sub> in liquid phase (2010)

Abstract BACKGROUND: Crude glycerol will increase to over 400 million L year −1 , and the market is likely to become saturated due to the limited demand for glycerol. The main aim of this work is to develop a novel process for the sustainable conversion of glycerol to 1,2‐propanediol (l,2‐PD). RESULTS: Cu‐H 4 SiW 12 O 40 /Al 2 O 3 catalysts with different H 4 SiW 12 O 40 (STA) loadings were prepared for the hydrogenolysis of glycerol to produce l,2‐PD in liquid phase. At 513 K, 6 MPa and LHSV of 0.9 h −1 in 10% (w/w) glycerol aqueous solutions, the catalyst with 5% (w/w) STA showed the best performance with 90.1% of glycerol conversion and 89.7% selectivity to l,2‐PD. More important, both the initial glycerol conversion and l,2‐PD selectivity were maintained over 250 h. CONCLUSION: l,2‐PD can be continuously produced with high yields via the liquid phase hydrogenolysis of glycerol over Cu‐H 4 SiW 12 O 40 /Al 2 O 3 . Furthermore, the characterization indicated that catalyst acidity could be greatly modified by STA, which promoted Cu reducibility. It was also found that hydrogenolysis could be favored by a bi‐functional catalyst with the appropriate amount of both acid and metal sites. Copyright © 2010 Society of Chemical Industry
Increasing enrollment for the Medicare Savings Programs. (2001)

Financial assistance for people with Medicare with low or moderate incomes is available through the Medicare Savings Programs. Yet many people who could use these benefits are unaware that they exist or are reluctant to apply for them. This brief describes efforts that you can undertake to increase awareness about the Medicare Savings Programs and to help your clients apply for these programs.
Localized induction heating solder bonding for wafer level MEMS packaging (2004)

This paper reports a new solder bonding method for the wafer level packaging of MEMS devices. Electroplated magnetic film was heated using induction heating causing the solder to reflow. The experiment results show that it took less than 1 min to complete the bonding process. In addition, the MEMS devices experienced a temperature of only 110 °C during bonding, thus thin film materials would not be damaged. Moreover, the bond strength between silicon and silicon wafer was higher than 18 MPa. The step height of the feed-through wire (acting as the electrical feed-through of the bonded region) is sealed by the electroplated film. Thus, the flatness and roughness of the electroplated surface are recovered by the solder reflow, and the package for preventing water leakage can be achieved. The integration of the surface micromachined devices with the proposed packaging techniques was demonstrated.
Defect reduction in strained In<i>x</i>Ga1−<i>x</i>As via growth on GaAs (100) substrates patterned to submicron dimensions (1990)

The misfit dislocation (MD) behavior of InxGa1−xAs (x≤0.15) grown via molecular beam epitaxy on GaAs(100) substrates containing parallel mesas of ultrasmall widths (0.6–1.3 μm) is examined via cross-sectional transmission electron microscope studies. A virtual absence of MDs running perpendicular to the mesa widths is found even though the film thicknesses are significantly larger than the so-called critical thickness for growth on nonpatterned substrates. In the nonpatterned regions of the substrate the mean separation of such MDs is ∼1500 Å and ∼940 Å for x=0.11 and x=0.15, respectively. The defect reduction observed is discussed in light of intrinsic effects relating to growth kinetics and strain relief at mesa edges and/or reduced dislocation multiplication occurring on the mesas.
Aluminum-nitrogen isoelectronic trap in silicon (1990)

The A, B, C luminescence system from silicon is believed to originate with the radiative decay of an exciton bound to an isoelectronic trap. It was shown previously by Sauer, Weber, and Zulehner [Appl. Phys. Lett. 44, 440 (1984)] that nitrogen is one of the trap constituents. We present experimental evidence that confirms that aluminum is also a trap constituent, suggesting that the trap is an aluminum-nitrogen pair.
The System‐Maintenance Role of the White Psychologist (1973)

A practicing investigator cognizant of the limitations of science claims that the white psychologist cannot help but maintain the current social system since he is rewarded quite well by it for his current activities. If he were to radically change his current activities, he would no longer be rewarded by the system in which he functions. The common dimension characteristic of white psychologists, justification for the status quo, manifests itself in three distinct orientations: (a) bio‐asocial‐ism which justifies traditional instrumentation, (b) cultural pathologism which justifies traditional paradigms, and (c) integrationism which justifies traditional policies. A further two‐fold dimension common to these orientations is a belief that black people are similar enough to white people to permit measurement by common instruments, and different enough from white people to justify scientific research into the causes of the differences.
A design approach to socially adaptive lighting environments (2011)

Historically light has been a catalyst for social life to emerge. In recent years of lighting research the social effect of light has been underexposed. The environments we occupy on a daily basis are used for a wider variety of activities. Consequently, lighting conditions need to become sensitive to adapt to the variety of activities being performed. We argue that the effect of light on the social relations between people needs to be considered in order to make adaptive lighting environments viable. To design a socially adaptive lighting environment an approach needs to be used that is iterative, experiential and involves multiple users in an actual context. The design process is described in three stages (Interactive Sketching, a Design Experiment and Socially Situated Adaptive Experience); for each stage the aims, the setup, results and lessons learned are provided. In this process an experimental environment is used, named Incubation environment, which is set up as a dining environment and equipped with computer controllable lighting armatures. In the final design stage the Socially Situated Adaptive Experience technique is described and is found a suitable technique to design socially adaptive lighting environments.
Reuse of software in distributed embedded automotive systems (2004)

Until recently, in the automotive industry, reuse of software has entirely been a typical activity of suppliers. They try to reduce the increasing software development costs that stem from rising complexity and size of software in the modern automobile. Lately, also the automotive manufacturers began to develop specific software with competitive relevance. Now they have to deal with the problem of reuse, too. Nevertheless, there is a difference between the manufacturers' and the suppliers' point of view because the manufacturers have to integrate the networked hardware components to one automotive system. Therefore, the manufacturers have to deal with additional problems compared to the supplier. At the beginning of this paper, the specific problems of reuse of software in the automotive domain are shown from the perspective of automotive manufacturers. After that, a framework is proposed to deal with these problems. Moreover, the application of this framework is shown in a realistic application example.
The efficacy of pregabalin and benzodiazepines in generalized anxiety disorder presenting with high levels of insomnia (2009)

The objective of this study was to assess the impact of high levels of insomnia on response to pregabalin (PGB) in patients with generalized anxiety disorder (GAD). Pooled data were analyzed from six double-blind, placebo-controlled, 4- to 6-week trials of outpatients who met the Diagnostic and Statistical Manual of Mental Disorders (fourth edition) criteria for GAD with a minimum Hamilton Rating Scale for Anxiety (HAM-A) score = 18. Response was evaluated for three fixed-dose PGB groups (150, 300-450, 600 mg/day), and for a benzodiazepine group (alprazolam or lorazepam). A 'high-insomnia' subgroup was defined by a baseline HAM for Depression (HAM-D) insomnia factor score greater than 3 (maximum = 6). At baseline, 1002 (54%) patients met the criteria for the high-insomnia subgroup, and 852 (46%) for the low-insomnia subgroup. Mean baseline HAM-A scores were 1-2 points higher in high-insomnia versus low-insomnia patients. In high-insomnia patients, PGB produced significantly greater improvement in HAM-A total scores at last observation carried forward endpoint on 300-450 mg (-13.1+/-0.6) and 600 mg (-11.2+/-0.5) dose groups compared with placebo (-8.3+/-0.5; P<0.0001 for both comparisons); the improvement on PGB 150 mg was not significant (-9.9+/-0.7; P = 0.051). Improvement was significant in the benzodiazepine group (-11.0+/-0.6; P<0.0001). In the high-insomnia subgroup, treatment with PGB significantly (P<0.001) improved the HAM-D insomnia factor scores on both the 300-450 mg (-2.73) and 600 mg (-2.35) doses, and on benzodiazepines (-2.52) compared with placebo (-1.51); improvement on PGB 150 mg (-1.69) was not significant. Rates of treatment-emergent insomnia were lower on PGB compared with placebo in both the high- and low-insomnia subgroups. In conclusion, PGB was well tolerated, and improved overall anxiety symptoms, while specifically improving insomnia in patients with GAD presenting with high levels of concurrent insomnia.
Differentiation of bone and soft tissues in formalin-fixed, paraffin-embedded tissue by using methylene blue/acid fuchsin stain. (2004)

In addition to the superior staining properties of methylene blue/acid fuchsin, other benefits of this stain include its stability, ease of use and low cost. This stain has many potential applications in the study of erosive bone disease in humans and also in animal models for research.
Direct Quantification of Gold along a Single Si Nanowire (2008)

The presence of gold on the sidewall of a tapered, single silicon nanowire is directly quantified from core-level nanospectra using energy-filtered photoelectron emission microscopy. The uniform island-type partial coverage of gold determined as 0.42+/-0.06 (approximately 1.8 ML) is in quantitative agreement with the diameter reduction of the gold catalyst observed by scanning electron microscopy and is confirmed by a splitting of the photothresholds collected from the sidewall, from which characteristic local work functions are extracted using a model of the full secondary electron distributions.
The efficacy of thymosin in the treatment of chronic hepatitis B virus infection: a meta‐analysis (2001)

Thymosin is effective in suppressing viral replication in chronic hepatitis B virus infection, but the effect is delayed until 12 months after the cessation of treatment.
Influence on electrical characteristics of the design of 4H-SiC ultraviolet photodetectors: Theoretical analysis and simulations (2012)

This paper deals with the simulation of the reverse current density of 4H-SiC ultraviolet- (UV) photodetector devices based on p-i-n diodes. Simulations using the finite-element method presented in this paper lead to an understanding of the photodetector current density levels in dark field, as well as under UV exposure. The theoretical study coming from these simulations allows us to propose some UV-photodetector performance enhancements. A way to improve the UV-photodetector performance is to increase the current density at reverse bias. This study demonstrates the improvement in electrical characteristics achievable by either optical or electrical means. Optical simulations prove that an increase in photon harvesting is possible by using a specific patterned surface, a surface grating which behaves as a photonic crystal. In addition to the absorption enhancement achieved caused by this kind of surface, we point out wavelength selectivity. Nevertheless, the electrical simulation confirms that the electric field placement is of primary importance. To ensure that the photon absorption is carried out inside the space-charge region, the simulation study leads us to propose a UV-photodetector comprising a “flat-top pyramid” surface.
Binary Stereo Matching (2013)

In this paper, we propose a novel binary-based cost computation and aggregation approach for stereo matching problem. The cost volume is constructed through bitwise operations on a series of binary strings. Then this approach is combined with traditional winner-take-all strategy, resulting in a new local stereo matching algorithm called binary stereo matching (BSM). Since core algorithm of BSM is based on binary and integer computations, it has a higher computational efficiency than previous methods. Experimental results on Middlebury benchmark show that BSM has comparable performance with state-of-the-art local stereo methods in terms of both quality and speed. Furthermore, experiments on images with radiometric differences demonstrate that BSM is more robust than previous methods under these changes, which is common under real illumination. 1.
Circumferential stretching of saphenous vein smooth muscle enhances vasoconstrictor responses by Rho kinase-dependent pathways (2002)

The circumferential deformations imposed by simulated arterial perfusion alter the vasomotor responses of saphenous vein smooth muscle. These effects are independent of new protein synthesis or the activation of stretch activated cation channels. The Rho kinase pathway appears to mediate the signalling mechanisms leading to increased agonist-induced tension and the increased sensitivity to vasoconstrictors.
Left Ventricular Contractility Varies Directly with Blood Ionized Calcium (1988)

Variations in Ca2+ are directly correlated with clinically significant changes in myocardial contractility.
AUTOMATIC STEREO MATCHING USING OPTICAL FLOW FOR 3D OBJECT MODELING (2000)

In order to acquire 3D spatial data for objects using stereo image, stereo matching such as SSDA, area based matching and so on have been proposed. However, there are some issues for efficient 3D object modeling. In particular, efficient line matching for reconstruction of the objects such as buildings is needed to be resolved. With this objective, this paper investigates automatic stereo matching method using optical flow estimation. Furthermore, this paper investigates a 3D spatial data acquisition method using coplanarity condition, and shows 3D modeling of a building which was performed automatically.
Sympathetic responses to vestibular activation in humans (2008)

Activation of sympathetic neural traffic via the vestibular system is referred to as the vestibulosympathetic reflex. Investigations of the vestibulosympathetic reflex in humans have been limited to the past decade, and the importance of this reflex in arterial blood pressure regulation is still being determined. This review provides a summary of sympathetic neural responses to various techniques used to engage the vestibulosympathetic reflex. Studies suggest that activation of the semicircular canals using caloric stimulation and yaw rotation do not modulate muscle sympathetic nerve activity (MSNA) or skin sympathetic nerve activity (SSNA). In contrast, activation of the otolith organs appear to alter MSNA, but not SSNA. Specifically, head-down rotation and off-vertical axis rotation increase MSNA, while sinusoidal linear accelerations decrease MSNA. Galvanic stimulation, which results in a nonspecific activation of the vestibule, appears to increase MSNA if the mode of delivery is pulse trained. In conclusion, evidence strongly supports the existence of a vestibulosympathetic reflex in humans. Furthermore, attenuation of the vestibulosympathetic reflex is coupled with a drop in arterial blood pressure in the elderly, suggesting this reflex may be important in human blood pressure regulation.
Dry age-related macular degeneration: A currently unmet clinical need (2012)

Age-related macular degeneration (AMD) is a leading cause of severe visual impairment and disability in older people worldwide. Although considerable advances in the management of the neovascular form of AMD have been made in the last decade, no therapy is yet available for the advanced dry form of AMD (geographic atrophy). This review focuses on current trends in the development of new therapies targeting specific pathophysiological pathways of dry AMD. Increased understanding of the complex mechanisms that underlie dry AMD will help to address this largely unmet clinical need.