gebhart/patrepeval huggingface dataset:
POLAR MICRO STRUCTURES OF THE <font>B</font><sub>2</sub>- AND <font>B</font><sub>4</sub>-PHASES OF BENT-SHAPED LC-MOLECULES RESOLVED BY NONLINEAR OPTICAL MICROSCOPY (2006)

A nonlinear optical (NLO) microscope has been developed based on recording the second harmonic generation (SHG) signals of the B 2 - and B 4 -phases of bent shaped liquid crystalline (LC) materials. We observed that the microstructures of the polar order can be accurately characterized by 2D scanned images implementing this device. Specifically, we have investigated two bent-core compounds, which have either B 4 or B 2 phases at room temperature and exhibit SHG activity. The NLO microscope was calibrated according to the Maker-fringes method allowing the in situ evaluation of the relative SHG efficiency. The developed NLO microscopy device may serve as an important tool to characterize liquid crystalline features at a microscopic scale for both fundamental and applied research.
Sex Discrimination and Geography: The Case of Ellen Churchill Semple (1974)

Click to increase image sizeClick to decrease image size Notes ∗I wish to thank William A. Koelsch, Associate Professor of History and Geography and Archivist of Clark University, for calling the relevant contents of Ellen Churchill Semple's will to my attention.
GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice (2011)

Tregs not only keep immune responses to autoantigens in check, but also restrain those directed toward pathogens and the commensal microbiota. Control of peripheral immune homeostasis by Tregs relies on their capacity to accumulate at inflamed sites and appropriately adapt to their local environment. To date, the factors involved in the control of these aspects of Treg physiology remain poorly understood. Here, we show that the canonical Th2 transcription factor GATA3 is selectively expressed in Tregs residing in barrier sites including the gastrointestinal tract and the skin. GATA3 expression in both murine and human Tregs was induced upon TCR and IL-2 stimulation. Although GATA3 was not required to sustain Treg homeostasis and function at steady state, GATA3 played a cardinal role in Treg physiology during inflammation. Indeed, the intrinsic expression of GATA3 by Tregs was required for their ability to accumulate at inflamed sites and to maintain high levels of Foxp3 expression in various polarized or inflammatory settings. Furthermore, our data indicate that GATA3 limits Treg polarization toward an effector T cell phenotype and acquisition of effector cytokines in inflamed tissues. Overall, our work reveals what we believe to be a new facet in the complex role of GATA3 in T cells and highlights what may be a fundamental role in controlling Treg physiology during inflammation.
Phasor dynamics of thyristor-controlled series capacitor systems (1997)

This paper develops simple but accurate continuous-time, large-signal dynamic models for a thyristor-controlled series capacitor (TCSC). The models are based on the representation of voltages and currents as time-varying Fourier series, and focus on the dynamics of the short-term Fourier coefficients. Truncating the series to keep only the fundamental components provides a natural dynamic generalization of the familiar quasi-static phasor representation. Systematic simplifications or refinements of their fundamental phasor dynamics model yield a variety of other models. The authors establish that even the simplest of these models predicts the dynamic behavior of the TCSC very accurately. Their phasor models provide a powerful basis for simulation, more than an order of magnitude faster than detailed time-domain circuit simulation. The phasor models present an attractive alternative to sampled-data models, having the advantages of simpler representation, modularity and direct compatibility with the phasor models that are routinely used to represent the dynamics of generators and other power system components.
On the morphology of polymer‐based photovoltaics (2012)

Abstract We review the morphologies of polymer‐based solar cells and the parameters that govern the evolution of the morphologies and describe different approaches to achieve the optimum morphology for a BHJ OPV. While there are some distinct differences, there are also some commonalities. It is evident that morphology and the control of the morphology are important for device performance and, by controlling the thermodynamics, in particular, the interactions of the components, and by controlling kinetic parameters, like the rate of solvent evaporation, crystallization and phase separation, optimized morphologies for a given system can be achieved. While much research has focused on P3HT, it is evident that a clearer understanding of the morphology and the evolution of the morphology in low bad gap polymer systems will increase the efficiency further. While current OPVs are on the verge of breaking the 10% barrier, manipulating and controlling the morphology will still be key for device optimization and, equally important, for the fabrication of these devices in an industrial setting. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2012
Nucleotide sequence and regulation of the Escherichia coli gene for ferrienterobactin transport protein FepB (1989)

The Escherichia coli fepB gene encodes a periplasmic protein required for ferrienterobactin transport; four fepB-related polypeptides are resolved by standard sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In vitro DNA-directed protein-synthesizing systems and experiments with the inhibitors dinitrophenol, carbonyl cyanide m-chlorophenylhydrazone, and ethanol demonstrated that the initial fepB translation product is processed. The nucleotide sequence of fepB and neighboring regions was determined. The predicted proFepB has a molecular weight of 34,255, consists of 318 amino acids, and is devoid of cysteine residues. A leader peptide is present, as are three possible leader peptidase cleavage sites after positions 22, 23, and 26. The upstream regulatory region included a Fur box, indicating that fepB is iron regulated, which was verified by RNA dot blot experiments. The regulatory region included a 68-amino-acid open reading frame (ORF) that encompassed a sequence capable of forming a large stem-and-loop structure. Indirect evidence indicated that this ORF must be translated for fepB transcription to occur. Six copies of the nonomer CCCTC(A/T)CCC or its invert were present in the stem-and-loop region. An ORF of unknown significance was found downstream from fepB; its product would have a molecular weight of 18,036 and be rich in proline and alanine. Processing of proFepB remains unclear, but the appearance of the three smaller members of the FepB family required the action of leader peptidase and the presence of the entire fepB gene.
Molecular Design Principle of All‐organic Dyes for Dye‐Sensitized Solar Cells (2013)

Abstract All‐organic dyes have shown promising potential as an effective sensitizer in dye‐sensitized solar cells (DSSCs). The design concept of all‐organic dyes to improve light‐to‐electric‐energy conversion is discussed based on the absorption, electron injection, dye regeneration, and recombination. How the electron‐donor–acceptor‐type framework can provide better light harvesting through bandgap‐tuning and why proper arrangement of acceptor/anchoring groups within a conjugated dye frame is important in suppressing improper charge recombination in DSSCs are discussed. Separating the electron acceptor from the anchoring unit in the donor–acceptor‐type organic dye would be a promising strategy to reduce recombination and improve photocurrent generation.
Essential roles of 70kDa heat inducible proteins (1989)

The 70 kDa heat inducible proteins (hsp70s) are a highly conserved family of proteins found in every organism examined. Some hsp70 proteins are essential for cell viability. Recent work has revealed that these proteins are involved in the movement of proteins into and through various compartments of the eukaryotic cell.
Synthesis and Metabolism of 6-Hydroxycatecholamines<sup>*</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Metabolism of 6-Hydroxycatecholamines*J. W. Daly, J. Benigni, R. Minnis, Y. Kanaoka, and B. WitkopCite this: Biochemistry 1965, 4, 11, 2513–2525Publication Date (Print):November 1, 1965Publication History Published online1 May 2002Published inissue 1 November 1965https://pubs.acs.org/doi/10.1021/bi00887a035https://doi.org/10.1021/bi00887a035research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Herd prevalence and geographic distribution of, and risk factors for, bovine paratuberculosis in Wisconsin. (1994)

A random sample of Wisconsin dairy herds, stratified by herd size, were tested for paratuberculosis by use of an absorbed ELISA procedure. The ELISA was optimized for overall accuracy by means of receiver operating characteristic curve analysis, and had a sensitivity and specificity of 50.9 and 94.9%, respectively. Herd prevalence was analyzed for correlation with responses to a management practices questionnaire completed by the herd owners. One hundred and fifty-eight herds and 4,990 cattle were tested. Of these, 50% of herds and 7.29% of cattle had positive test results. Calculation of true prevalence from the apparent prevalence indicated that 4.79% of cattle and 34% of the Wisconsin dairy herds tested had serologic evidence of paratuberculosis. Among the 54 herds classified as positive on the basis of true prevalence estimation, the mean number of test positive cattle was 20.3%. The geographic distribution of herds with positive results was not uniform. More infected herds were found in the southern and western districts of Wisconsin than in the eastern district. The west-central district had a larger number of infected herds than did other districts. By use of chi 2 analysis, the only management factor found to be significantly associated with herd prevalence was housing of calves after weaning (P = 0.03). Specifically, in herds with higher prevalence, calves were separated after weaning into calf barns and hutches rather than into pens in the cow barn more often than in herds with lower prevalence. This factor was also considered significant by use of logistic regression analysis.(ABSTRACT TRUNCATED AT 250 WORDS)
Interconnection between thyroid hormone signalling pathways and parvovirus cytotoxic functions (1993)

Nonstructural (NS) proteins of autonomous parvoviruses can repress expression driven by heterologous promoters, an activity which thus far has not been separated from their cytotoxic effects. It is shown here that, in transient transfection assays, the NS-1 protein of the parvovirus minute virus of mice (MVMp) activates the promoter of the human c-erbA1 gene, encoding the thyroid hormone (T3) receptor alpha. The endogenous c-erbA1 promoter is also a target for induction upon MVMp infection. Moreover, T3 was found to up-modulate the level of cell sensitivity to parvovirus attack. These data suggest an interconnection between T3 signalling and NS cytotoxic pathways.
Comparative Effects of Telmisartan in the Treatment of Hypertension (2002)

Three separate randomized, double-blind, parallel-group, 12-week trials compared telmisartan with enalapril, lisinopril, and amlodipine for treating mild to moderate hypertension. Telmisartan 80 mg was associated with a significantly greater mean decrease in trough systolic and diastolic blood pressure than enalapril 20 mg (p<0.05). Mean decreases in trough systolic and diastolic blood pressure with telmisartan (40, 80, and 160 mg) and lisinopril (10, 20, and 40 mg) were similar. Telmisartan (40, 80, and 120 mg) provided greater decreases in mean hourly systolic and diastolic blood pressure throughout the 24-hour dosing interval, including the last 4 hours of the dosing period, than amlodipine (5 and 10 mg). Telmisartan was associated with a lower incidence of treatment-related cough than lisinopril and enalapril and less treatment-related angioedema than amlodipine. These data suggest that for treating mild to moderate hypertension, telmisartan has efficacy similar to lisinopril, greater efficacy than enalapril and amlodipine throughout the 24-hour dosing interval, and better tolerability than these angiotensin-converting enzyme inhibitors and amlodipine.
Reducing power while increasing performance with supercisc (2006)

Multiprocessor Systems on Chips (MPSoCs) have become a popular architectural technique to increase performance. However, MPSoCs may lead to undesirable power consumption characteristics for computing systems that have strict power budgets, such as PDAs, mobile phones, and notebook computers. This paper presents the super-complex instruction-set computing (SuperCISC) Embedded Processor Architecture and, in particular, investigates performance and power consumption of this device compared to traditional processor architecture-based execution. SuperCISC is a heterogeneous, multicore processor architecture designed to exceed performance of traditional embedded processors while maintaining a reduced power budget compared to low-power embedded processors. At the heart of the SuperCISC processor is a multicore VLIW (Very Large Instruction Word) containing several homogeneous execution cores/functional units. In addition, complex and heterogeneous combinational hardware function cores are tightly integrated to the core VLIW engine providing an opportunity for improved performance and reduced energy consumption. Our SuperCISC processor core has been synthesized for both a 90-nm Stratix II Field Programmable Gate Aray (FPGA) and a 160-nm standard cell Application-Specific Integrated Circuit (ASIC) fabrication process from OKI, each operating at approximately 167 MHz for the VLIW core. We examine several reasons for speedup and power improvement through the SuperCISC architecture, including predicated control flow , cycle compression , and a reduction in arithmetic power consumption, which we call power compression . Finally, testing our SuperCISC processor with multimedia and signal-processing benchmarks, we show how the SuperCISC processor can provide performance improvements ranging from 7X to 160X with an average of 60X, while also providing orders of magnitude of power improvements for the computational kernels. The power improvements for our benchmark kernels range from just over 40X to over 400X, with an average savings exceeding 130X. By combining these power and performance improvements, our total energy improvements all exceed 1000X. As these savings are limited to the computational kernels of the applications, which often consume approximately 90% of the execution time, we expect our savings to approach the ideal application improvement of 10X.
Accuracy and Criteria for Localizing Arterial Occlusion With Transcranial Doppler (2000)

The authors determined transcranial Doppler (TCD) accuracy for the proximal internal carotid artery (ICA), distal ICA, proximal middle cerebral artery (MCA), distal MCA, anterior cerebral artery (ACA), posterior cerebral artery (PCA), terminal vertebral artery (tVA), and basilar artery (BA) occlusion in cerebral ischemia patients. Detailed diagnostic criteria were prospectively applied for TCD interpretation independent of angiographic findings. Of 320 consecutive patients referred to the neurosonology service with symptoms of cerebral ischemia, 190 (59%) patients also underwent angiography (MRA or DSA). 48 of those 190 patients had angiographic occlusion and 12 of those 48 patients had involvement of multiple vessels. Median time from TCD until angiography was performed was 1 hour (41 patients had angiography before TCD). TCD showed 40 true positive, 8 false negative, 8 false positive, and 134 true negative studies with sensitivity 83.0%, specificity 94.4%, positive predictive value 83.0%, negative predictive value 94.4%, and accuracy 91.6% to determine all sites of occlusion. Sensitivity for each individual occlusion site was: proximal ICA 94%, distal ICA 81%, MCA 93% tVA 56%, BA 60%. Specificity ranged from 96% to 98%. TCD is sensitive and specific in determining the site of the arterial occlusion using detailed diagnostic criteria, including proximal ICA and distal MCA lesions. TCD has the highest accuracy for ICA and MCA occlusions. If the results of TCD are normal, there is at least a 94% chance that angiographic studies will be negative.
<i>N-tert</i>-Butanesulfinyl Imines:  Versatile Intermediates for the Asymmetric Synthesis of Amines (2002)

N-tert-Butanesulfinyl aldimines 3 and ketimines 4 are exceedingly versatile intermediates for the asymmetric synthesis of amines. The N-tert-butanesulfinyl imines are prepared in high yields by condensing enantiomerically pure tert-butanesulfinamide 1, which is readily available in either configuration, with a wide range of aldehydes and ketones. The tert-butanesulfinyl group activates the imines for the addition of many different classes of nucleophiles, serves as a powerful chiral directing group, and after nucleophilic addition is readily cleaved by treatment of the product with acid. A wide range of highly enantioenriched amines, including alpha-branched and alpha,alpha-dibranched amines, alpha- and beta-amino acids, 1,2- and 1,3-amino alcohols, and alpha-trifluoromethyl amines, are efficiently synthesized using this methodology. In addition, N-tert-butanesulfinyl imine derivatives provide a new family of ligands for asymmetric catalysis.
Copy number variations independently induce autism spectrum disorder (2017)

The examination of copy number variation (CNV) is critical to understand the etiology of the CNV-related autism spectrum disorders (ASD). DNA samples were obtained from 64 ASD probands, which were genotyped on an Affymetrix CytoScan HD platform. qPCR or FISH were used as a validation for some novel recurrent CNVs. We further compared the clinical phenotypes of the genes in the Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources (DECIPHER) database with these overlapping genes. Using vast, readily available databases with previously reported clinically relevant CNVs from human populations, the genes were evaluated using Enrichment Analysis and GO Slim Classification. By using the Ploysearch2 software, we identified the interaction relationship between significant genes and known ASD genes. A total of 29 CNVs, overlapping with 520 genes, including 315 OMIM genes, were identified. Additionally, myocyte enhancer factor 2 family (MEF2C) with two cases of CNV overlapping were also identified. Enrichment analysis showed that the 520 genes are most likely to be related to membrane components with protein-binding functions involved in metabolic processes. In the interaction network of those genes, the known ASD genes are mostly at the core position and the significant genes found in our samples are closely related to the known ASD genes. CNVs should be an independent factor to induce autism. With the strategy of our study, we could find the ASDs candidate genes by CNV data and review certain pathogenesis of this disorder. Those CNVs were associated with ASD and they may contribute to ASD by affecting the ASD-related genes.
Internal and external alkali ion complexes of enniatin B: an empirical force field analysis (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInternal and external alkali ion complexes of enniatin B: an empirical force field analysisShneior Lifson, Clifford E. Felder, and Abraham ShanzerCite this: Biochemistry 1984, 23, 12, 2577–2590Publication Date (Print):June 1, 1984Publication History Published online1 May 2002Published inissue 1 June 1984https://doi.org/10.1021/bi00307a007Request reuse permissionsArticle Views50Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Biological Degradation of Pesticide Wastes in the Root Zone of Soils Collected at an Agrochemical Dealership (1994)

Evidence for enhanced microbial degradation of xenobiotic chemicals in the rhizosphere, a zone of increased microbial activity at the root-soil interface, continues to accrue, suggesting that vegetation may play an important role in facilitating bioremediation of contaminated surface soils. For sites tainted with pesticide wastes, such as at agrochemical dealerships, establishing vegetation may be problematic because of the presence of herbicide mixtures at concentrations severalfold above field application rates. Nonetheless, herbicide-tolerant plants exist that can survive in these environments, and they are ideal candidates for testing the influence of rhizosphere microbial communities on the degradation of pesticide wastes. Experiments in this laboratory have tested whether a commodity plant such as soybean could survive in soil from a pesticide-contaminated site containing a mixture of three predominant herbicides, atrazine, metolachlor, and trifluralin, and if its presence could enhance biodegradation. Although soybean survival in this soil was high, its presence did not enhance the degradation of the chemicals. Tests with nonvegetated soils and rhizosphere soils from Kochia sp., a herbicide-tolerant plant, showed enhanced degradation of these chemicals in rhizosphere soil. Also, Kochia sp. seedlings have emerged from rhizosphere soils spiked with additional concentrations of the three test chemicals, indicating the ability of these plants to survive in soils containing high concentrations of herbicide mixtures.