gebhart/patrepeval huggingface dataset:
False-negative serological HLA-B27 typing results may be due to altered antigenic epitopes and can be detected by polymerase chain reaction (1997)

Serological typing with the microlymphocytotoxicity test (MLCT) and flow cytometry (FC) using HLA-B27 antisera is commonly used for the determination of HLA-B27. However, in some patients tested more than once, negative results have turned out to be positive at following investigations. We retested by polymerase chain reaction (PCR) samples from 20 randomly selected patients with reactive arthritis or Reiter's syndrome who had now been followed for 20 yr. Ten of the patients were originally tested to be HLA-B27 positive and 10 HLA-B27 negative by the MLCT. All 10 serologically HLA-B27 positive individuals were also positive in the PCR. However, 2/10 patients interpreted as being HLA-B27 negative were positive by PCR. At this time, the same two patients were also positive in the routine MLCT and FC using four different monoclonal antibodies against HLA-B27. PCR is superior to serological techniques to determine HLA-B27 positivity unequivocally, since it is based on the detection of HLA-B27 gene sequences.
High mortality in Nipah encephalitis is associated with presence of virus in cerebrospinal fluid (2000)

During the outbreak of Nipah virus encephalitis in Malaysia, stored cerebrospinal fluid (CSF) samples from 84 patients (27 fatal and 57 nonfatal cases) were cultured for the virus. The virus was isolated from 17 fatal cases and 1 nonfatal case. There were significant associations between CSF virus isolation and mortality as well as clinical features associated with poor prognosis. In addition, there was a positive linear correlation of CSF virus isolation with age. There was no significant association between CSF virus isolation and the character of the CSF, presence of Nipah-specific antibody in the serum or CSF, duration of illness before collection of samples, or sex or ethnicity of the patients. This study suggests that high viral replication in the central nervous system may be an important factor for high mortality. Ann Neurol 2000;48:802–805
An ESD-protection-free monolithic harmonic filter for WLAN applications (2010)

Modern multi-band and multi-mode handheld wireless devices require novel approaches for the integration of passive elements into the radio front-end. In this paper, we present the design of an electrostatic discharge (ESD)-protection-free harmonic filter using an improved high-resistivity silicon copper technology for the monolithic integration of active and passive devices. Typical metal-isolator-metal (MIM) capacitors are replaced by inter-digital metal capacitors which provide a high breakdown voltage of up to 800 V. As the machine-mode ESD voltage is lower than 500 V, this filter can operate without ESD protection. In this design, electromagnetic (EM) simulation was used extensively for inductor and filter optimization. The fabricated device has an insertion loss of less than 0.3 dB and 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> and 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> harmonic attenuations of more than 30 dB for the WLAN 2.4 GHz frequency band and features a size of 0.75×0.67 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Identification and Characterization of Four Chrysanthemum MADS-Box Genes, Belonging to the <i>APETALA1/FRUITFULL</i> and <i>SEPALLATA3</i> Subfamilies (2004)

Four full-length MADS-box cDNAs from chrysanthemum, designated Chrysanthemum Dendrathema grandiflorum MADS (CDM) 8, CDM41, CDM111, and CDM44, have been isolated and further functionally characterized. Protein sequence alignment and expression patterns of the corresponding genes suggest that CDM8 and CDM41 belong to the FRUITFULL (FUL) clade, CDM111 is a member of the APETALA1 (AP1) subfamily, and CDM44 is a member of the SEPALLATA3 (SEP3) subfamily of MADS-box transcription factors. Overexpression of CDM111 in Arabidopsis plants resulted in an aberrant phenotype that is reminiscent of the phenotype obtained by ectopic expression of the AP1 gene. In addition, CDM111 was able to partially complement the ap1-1 mutant from Arabidopsis, illustrating that CDM111 is the functional equivalent to AP1. Yeast two- and three-hybrid studies were performed to investigate the potential protein interactions and complexes in which these chrysanthemum MADS-box proteins are involved. Based on these studies, we conclude that CDM44 is most likely the SEP3 functional equivalent, because the CDM44 protein interacts with CDM proteins of the AP1/FUL and AG subfamilies, and as a higher order complex with the heterodimer between the presumed B-type CDM proteins.
Hexagons, Kinks, and Disorder in Oscillated Granular Layers (1995)

Experiments on vertically oscillated granular layers in an evacuated container reveal a sequence of well-defined pattern bifurcations as the container acceleration is increased. Period doublings of the layer center of mass motion and a standing wave instability interact to produce hexagons and more complicated patterns composed of distinct spatial domains of different relative phase separated by kinks (phase discontinuities). A simple model displays quantitative agreement with the observed transition sequence.
Review: <i>The Chinese Kinship System</i>, by Han-yi Fêng (1949)

Book Review| April 20 1949 Review The Chinese Kinship SystemHan-yi Fêng L. K. R. L. K. R. Search for other works by this author on: This Site PubMed Google Scholar Far Eastern Survey (1949) 18 (8): 95. https://doi.org/10.2307/3021303 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation L. K. R.; Review. Far Eastern Survey 20 April 1949; 18 (8): 95. doi: https://doi.org/10.2307/3021303 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAsian Survey Search This content is only available via PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
Coordination in software agent systems (1996)

The objective of this paper is to examine the crucial area of co-ordination in multi-agent systems. It does not attempt to provide a comprehensive overview of the co-ordination literature; rather, it highlights the necessity for co-ordination in agent systems and overviews briefly various co-ordination techniques. It critiques these techniques and presents some conclusions and challenges drawn from this literature.
Comparison of real-time, and qualitative polymerase chain reaction assays in detection of cytomegalovirus DNA in clinical specimens. (2007)

A good level of concordance between RT-PCR and Q-PCR assays for CMV DNA detection has been found.
Enabling fast preemption via Dual-Kernel support on GPUs (2017)

To consider QoS for resource-limited mobile systems, we introduce a fast preemption mechanism on GPUs. First, we involve a dual-kernel execution model to support fine-grained preemption, and a resource allocation policy to avoid resource fragmentation problem. Second, we propose a preemption victim selection scheme to reduce the throughput overhead while satisfying a required preemption latency. Evaluations show that we can reach very close to the ideal preemption scheme within 2% difference in terms of deadline violations. Furthermore, on average we improve GPU resource utilization by 2.93× over prior technique during preemption.
Mutagenicity of Nitroaromatic Compounds (2000)

ADVERTISEMENT RETURN TO ISSUEReviewNEXTMutagenicity of Nitroaromatic CompoundsVandana Purohit and Ashis K. BasuView Author Information Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269 Cite this: Chem. Res. Toxicol. 2000, 13, 8, 673–692Publication Date (Web):July 20, 2000Publication History Received7 January 2000Published online20 July 2000Published inissue 1 August 2000https://pubs.acs.org/doi/10.1021/tx000002xhttps://doi.org/10.1021/tx000002xreview-articleACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views2267Altmetric-Citations369LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Adducts,Genetics,Metabolism,Peptides and proteins,Rodent models Get e-Alerts
Nonlinear photon localization for high-intensity laser protection systems for photodetectors and eyes (1991)

A multilayer system of alternating high and low nonlinear materials can be designed to respond actively to the radiation intensity, whereby it transmits ambient light but rejects high-intensity light over a broad spectral region. The transmission of the low-intensity light is determined by the linear refractive indices of the multi-layer system, which can be designed to transmit the ambient light totally. The high-intensity laser radiation induces a change in the refractive indices through the nonlinear index, which changes the interface reflectance and randomizes the phase shift of each layer. This induced random one-dimensional system will totally reflect the high-intensity laser over a broad spectrum.
Dystrophin Expression in Muscles of mdx Mice After Adenovirus-Mediated <i>In Vivo</i> Gene Transfer (1996)

We have generated high-titer adenoviral recombinants (AVR) expressing a 6.3-kb partial dystrophin cDNA insert under the control of either the Rous sarcoma virus (RSV) or cytomegalovirus (CMV) promoter. These AVR preparations were free of both E1-containing AVR and AVR with a nonfunctional dystrophin expression cassette. With these optimal AVR preparations, we have obtained a high degree of short-term (10 days) expression of a truncated (approximately 200 kD) dystrophin in dystrophin-deficient mdx muscles injected in the neonatal period; a lesser degree of expression of dystrophin was found in muscles injected in the young adult age and in old animals. Microscopic indices of muscle damage revealed that the truncated dystrophin provided a significant protection of the transduced muscle fibers. However, by 60 days post-injection, a substantial reduction of the number of dystrophin-positive fibers was noted, even in the neonatally injected muscles, and near-total elimination of dystrophin-positive fibers occurred in muscles injected in the adult age. These effects appeared to be brought about by the activity of CD8+ cytotoxic lymphocytes directed against the transduced cells, leading to their eventual elimination. In severe combined immunodeficiency (SCID) mice, lacking both humoral and cellular immune competence, muscles transduced (either in the neonatal or adult age) by AVR containing a CMV-LacZ expression cassette maintained the early (10 day) transduction level up to 30 days post-injection. Systemic administration of AVR (i.e., into the left ventricle of the heart) led in 5 days to a high number of dystrophin-positive fibers in heart, diaphragm, and intercostal muscles but not in limb muscles.
PCS support in IS-54C (2002)

With the digital control channel for IS-54 that is being specified in TIA it is possible to use D-AMPS to provide personal communication services (PCS). Some of the key features of IS-54C are described and some of the new functionality is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mobile peer-to-peer frequency-hopping communications (2002)

The potential performance of mobile peer-to-peer frequency-hopping communication systems in multiple-access networks is studied. Through analysis and simulation, the effects of Rayleigh fading, shadowing, spectral splatter, the number of frequency channels, spatial diversity, and thermal noise are examined.
??9-THC induced hyperphagia and tolerance assessment: interactions between the CB1 receptor agonist ??9-THC and the CB1 receptor antagonist SR-141716 (rimonabant) in rats (2005)

This study examined effects of the CB1 receptor antagonist/inverse agonist SR-141716 and the CB1 receptor agonist delta9-tetrahydrocannabinol (delta9-THC) on feeding behavior in male Sprague-Dawley rats. Rats were housed individually with free access to regular pelletized laboratory chow [after a 2 weeks handling phase, animals had access to regular chow for 21 h (Study 1) or 22 h (Study 2); high-fat powder food for 3 h in Study 1 and 2 h in Study 2, respectively], and free access to water. Animals were maintained on a reversed 12-h light/dark cycle (dark beginning at noon). Rats were habituated to this type of feeding and light/dark schedule for 3 weeks until a stable baseline for food intake was achieved. In Study 1, animals were examined after administration of delta9-THC alone (dose range 0.1-1.8 mg/kg), SR-141716 alone (dose range 0.03-0.3 mg/kg), and the two drugs combined; injections were given i.p. at the beginning of the second hour after presenting the high-fat diet and drugs were given twice weekly. There was a dose-related increase in high-fat diet intake, peaking at 0.56-1 mg/kg delta9-THC. SR-141716 alone suppressed the high-fat diet intake below control levels. A combination of 0.3 mg/kg SR-141716 and 0.56 mg/kg delta9-THC counteracted the effects on consumption of either drug alone. In Study 2, experimental rats were treated initially with 0.56 mg/kg delta9-THC for six consecutive days; controls received vehicle. Attenuation of the hyperphagia (high-fat diet) was evident after the second injection. Increasing doses of delta9-THC (1 and 1.8 mg/kg, for two and three consecutive days, respectively) did not reinstate the initial hyperphagia. In conclusion, low-to-moderate doses of delta9-THC produced hyperphagia (to a high-fat food source), which was antagonized by SR-141716. SR-141716 singly suppressed intake of the high-fat diet. Delta9-THC-induced hyperphagia dissipated rapidly upon chronic treatment; however, it is unclear whether this reflects pharmacological tolerance or the emergence of a conditioned taste aversion in Study 2.
New 3-level submodules for a modular multilevel converter based HVDC system with advanced features (2013)

Modular multilevel converters have emerged as a viable solution over conventional voltage source converters (VSC) for applications in high voltage direct current (HVDC) transmission. Due to modular structure, the converter can reach high number of voltage levels resulting in low switching frequency and near sinusoidal voltage waveforms. This paper proposes new submodule topologies which can result in even higher voltage levels with reduced voltage stress across some switches and lower semiconductor losses. A modified modulation scheme and voltage balancing algorithm is proposed for the new topology and is validated by MATLAB/Simulink simulations. A comprehensive comparative analysis with other available submodule topologies is presented to show the added benefits.
Properties of an R Factor Which Originated in <i>Pseudomonas aeruginosa</i> 1822 (1972)

RP1, a group of genes specifying resistance to carbenicillin, neomycin, kanamycin, and tetracycline and originating in a strain of Pseudomonas aeruginosa, was freely transmissible between strains of P. aeruginosa, Escherichia coli, and Proteus mirabilis. Acquisition of the multiple drug resistance specified by RP1 by these strains was accompanied by acquisition of an extrachromosomal satellite of covalently closed circular deoxyribonucleic acid of molecular weight about 40 million daltons and of buoyant density 1.719 g/cm(3) (60% guanine plus cytosine).
Preparation and Application of Bacterial Cellulose Sphere: A Novel Biomaterial (2011)

This paper explores preparation of spherical bacterial cellulose (BC), a novel biomaterial, and its adsorption capacity is charaterized. The effect of shaking speed and culture duration on fermentation production of BC spheres is analyzed; BC spheres are produced after 72 h fermention at 30°C with a shaking speed of 160 rpm. The spheres have a diameter range of 3–5 mm. The scanning electron micrograph photograph shows that BC spheres have a loose and porous structure. Repetition using tests on adsorption of Bovine serum albumin (BSA) and Pb2+ had been carried out. The results indicated that BC spheres can be recovered from BSA-BC complex and Pb-BC complex by eluting with NaOH and sodium citrate solution, respectively. So BC spheres have a vast potential for application in the fields of biomaterial bioseparation and sewage treatment.
The Formation of Strong Intermolecular Interactions in Immiscible Blends of Poly(vinyl alcohol) (PVA) and Lignin (2003)

The intermolecular interactions of lignin with a hydrophilic polymer, poly(vinyl alcohol) (PVA), were studied using thermal analyses and FT-IR spectroscopy of a series of PVA/hardwood kraft lignin blend fibers prepared by thermal extrusion. Although two phases are observed in this blend system, some of the lignin was closely associated with the PVA in the PVA-rich phase. The crystallinity of the PVA fraction was reduced with increasing lignin content. An interaction energy density of -9.34 cal cm(-1), calculated from melting point depression data, suggests that strong intermolecular interactions exist between PVA and lignin. FT-IR analysis indicates the formation of strong intermolecular hydrogen bonds between the hydroxyl groups of PVA and lignin. Although the PVA/lignin blend system is immiscible in the bulk, the results herein show the existence of some specific intermolecular interaction between PVA and lignin.
Differential effects of <scp>BDNF</scp> and neurotrophin 4 (<scp>NT</scp>4) on endocytic sorting of TrkB receptors (2016)

Neurotrophins are a family of growth factors playing key roles in the survival, development, and function of neurons. The neurotrophins brain-derived neurotrophic factor (BDNF) and NT4 both bind to and activate TrkB receptors, however, they mediate distinct neuronal functions. The molecular mechanism of how TrkB activation by BDNF and NT4 leads to diverse outcomes is unknown. Here, we report that BDNF and NT4 lead to differential endocytic sorting of TrkB receptors resulting in diverse biological functions in cultured cortical neurons. Fluorescent microscopy and surface biotinylation experiments showed that both neurotrophins stimulate internalization of TrkB with similar kinetics. Exposure to BDNF for 2-3 h reduced the surface pool of TrkB receptors to half, whereas a longer treatment (4-5 h) with NT4 was necessary to achieve a similar level of down-regulation. Although BDNF and NT4 induced TrkB phosphorylation with similar intensities, BDNF induced more rapid ubiquitination and degradation of TrkB than NT4. Interestingly, TrkB receptor ubiquitination by these ligands have substantially different pH sensitivities, resulting in varying degrees of receptor ubiquitination at lower pH levels. Consequently, NT4 was capable of maintaining longer sustained downstream signaling activation that correlated with reduced TrkB ubiquitination at endosomal pH. Thus, by leading to altered endocytic trafficking itineraries for TrkB receptors, BDNF and NT4 elicit differential TrkB signaling in terms of duration, intensity, and specificity, which may contribute to their functional differences in vivo. The neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), both bind to and activate TrkB receptors, however, they mediate distinct neuronal functions. Here, we propose that BDNF and NT4 lead to differential endocytic sorting of TrkB receptors resulting in diverse biological functions. BDNF induces more rapid ubiquitination and degradation of TrkB than NT4. Consequently, NT4 is capable of maintaining more sustained signaling downstream of TrkB receptors.
SOMATIC EMBRYOGENESIS AND PLANT REGENERATION FROM IMMATURE ZYGOTIC EMBRYOS OF MUSCADINE GRAPE (VITIS ROTUNDIFOLIA) CULTIVARS (1992)

Embryogenic cell lines of Vitis rotundifolia were produced from immature zygotic embryo explants obtained by culturing ovules, harvested at 20 d postanthesis, for 8 wk and then dissecting embryos from them. Ovules cultured on Nitsch and Nitsch medium with naphthoxyacetic acid and benzyladenine (BA) produced a brown exudate, necessitating three transfers to fresh medium at 2‐wk intervals during the 8‐wk culture cycle. Zygotic embryos that were subsequently isolated from cultured ovules and placed on the same medium produced a heterogenous callus from which eventually emerged embryogenic cell lines. A higher percentage of ovules from cultivars ‘Dixie’, ‘Fry’, ‘Nesbitt’, and ‘Welder’ produced zygotic embryos (31%–39%) than did those from ‘Carlos’ (3%). A higher percentage of ‘Fry’ ovules produced embryogenic lines from cultured zygotic embryos (6.3%) than did those of the other four cultivars (1%–1.6%). Embryogenic cell lines were white and composed of variably sized cell clusters, somatic embryos, and embryonic tissue embedded in a watery matrix. These lines were maintained for over 1 yr on modified Murashige and Skoog (MS) medium lacking growth regulators by transfer of selected cell clusters every 6 wk. White, opaque somatic embryos grew directly from cell clusters and passed through recognizable developmental stages. Germination was induced by transfer of somatic embryos to MS medium with BA. Although 80%–100% of embryos germinated, plant recovery was low due to poor shoot development.
Evaluation of the Specificities of Five DNA Amplification Methods for the Detection of <i>Neisseria gonorrhoeae</i> (2003)

The intragenus specificities of five molecular diagnostic methods for Neisseria gonorrhoeae were determined. Three assays were considered suboptimal. Molecular detection of N. gonorrhoeae from sites where other Neisseria spp. commonly occur or from any site in low-prevalence settings should be confirmed by a test targeting a different genetic locus.
Massively parallel implementation of character recognition systems (1992)

A massively parallel character recogniuon system has been implemented. The system is designed to study the feasibility of the recogniuon of handprinted text in a loosely constrained environment The NIST handprint database,NIST Special Database 1, is used to provide test data for the recogniuon system.
Making Sense of Student Written Comments (2001)

Abstract Written comments from students frustrate most faculty who read them. There are ways to interpret the information and use it to improve teaching.