gebhart/patrepeval huggingface dataset:
Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice (2008)

As 5-lipoxygenase (5-LO) is an emerging target in obesity and insulin resistance, we have investigated whether this arachidonate pathway is also implicated in the progression of obesity-related fatty liver disease. Our results show that 5-LO activity and 5-LO-derived product levels are significantly elevated in the liver of obese ob/ob mice with respect to wild-type controls. Treatment of ob/ob mice with a selective 5-LO inhibitor exerted a remarkable protection from hepatic steatosis as revealed by decreased oil red-O staining and reduced hepatic triglyceride (TG) concentrations. In addition, 5-LO inhibition in ob/ob mice downregulated genes involved in hepatic fatty acid uptake (i.e., L-FABP and FAT/CD36) and normalized peroxisome proliferator-activated receptor alpha (PPARalpha) and acyl-CoA oxidase expression, whereas the expression of lipogenic genes [i.e., fatty acid synthase (FASN) and SREBP-1c] remained unaltered. Furthermore, 5-LO inhibition restored hepatic microsomal TG transfer protein (MTP) activity in parallel with a stimulation of hepatic VLDL-TG and apoB secretion in ob/ob mice. Consistent with these findings, 5-LO products directly inhibited MTP activity and triggered cytosolic TG accumulation in CC-1 cells, a murine hepatocyte cell line. Taken together, these findings identify a novel steatogenic role for 5-LO in the liver through mechanisms involving the regulation of hepatic MTP activity and VLDL-TG and apoB secretion.
Bcl-xL controls a switch between cell death modes during mitotic arrest (2014)

Antimitotic agents such as microtubule inhibitors (paclitaxel) are widely used in cancer therapy while new agents blocking mitosis onset are currently in development. All these agents impose a prolonged mitotic arrest in cancer cells that relies on sustained activation of the spindle assembly checkpoint and may lead to subsequent cell death by incompletely understood molecular events. We have investigated the role played by anti-apoptotic Bcl-2 family members in the fate of mitotically arrested mammary tumor cells treated with paclitaxel, or depleted in Cdc20, the activator of the anaphase promoting complex. Under these conditions, a weak and delayed mitotic cell death occurs that is caspase- and Bax/Bak-independent. Moreover, BH3 profiling assays indicate that viable cells during mitotic arrest are primed to die by apoptosis and that Bcl-xL is required to maintain mitochondrial integrity. Consistently, Bcl-xL depletion, or treatment with its inhibitor ABT-737 (but not with the specific Bcl-2 inhibitor ABT-199), during mitotic arrest converts cell response to antimitotics to efficient caspase and Bax-dependent apoptosis. Apoptotic priming under conditions of mitotic arrest relies, at least in part, on the phosphorylation on serine 62 of Bcl-xL, which modulates its interaction with Bax and its sensitivity to ABT-737. The phospho-mimetic S62D-Bcl-xL mutant is indeed less efficient than the corresponding phospho-deficient S62A-Bcl-xL mutant in sequestrating Bax and in protecting cancer cells from mitotic cell death or yeast cells from Bax-induced growth inhibition. Our results provide a rationale for combining Bcl-xL targeting to antimitotic agents to improve clinical efficacy of antimitotic strategy in cancer therapy.
The Effect of Fuel Composition and Engine Operating Parameters on Injector Deposits in a High-Pressure Direct Injection Gasoline (DIG) Research Engine (1999)

<div class="htmlview paragraph">The effects of fuel composition and engine operating parameters on high-pressure, direct injection gasoline (DIG) injector plugging and deposit formation have been studied. The engine used was a conventional dual-sparkplug, 2.2-liter Nissan engine modified for direct injection using one of the spark plug holes. The engine was run under 20% rich conditions to accelerate deposit formation. A ten-fuel test matrix was designed around T90, sulfur level, and olefin levels indicated in the European gasoline specifications for year 2000. The gasolines, containing no detergents, were formulated using refinery stream blends to match the specified targets. Injector flow loss was monitored by fuel flow to the engine and monitoring oxygen sensors on each of the four cylinders. The impact of fuel composition on deposit formation and injector plugging is discussed. Injector flow loss was strongly influenced by injector tip temperature. Possible causes of deposit formation were investigated through analysis of injector deposits.</div>
Activation of AMP-activated Protein Kinase Inhibits Protein Synthesis Associated with Hypertrophy in the Cardiac Myocyte (2004)

A necessary mediator of cardiac myocyte enlargement is protein synthesis, which is controlled at the levels of both translation initiation and elongation. Eukaryotic elongation factor-2 (eEF2) mediates the translocation step of peptide-chain elongation and is inhibited through phosphorylation by eEF2 kinase. In addition, p70S6 kinase can regulate protein synthesis by phosphorylating eEF2 kinase or via phosphorylation of ribosomal protein S6. We have recently shown that eEF2 kinase is also controlled by phosphorylation by AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis. Moreover, the mammalian target of rapamycin has also been shown to be inhibited, indirectly, by AMPK, thus leading to the inhibition of p70S6 kinase. Although AMPK activation has been shown to modulate protein synthesis, it is unknown whether AMPK could also be a regulator of cardiac hypertrophic growth. Therefore, we investigated the role of AMPK activation in regulating protein synthesis during both phenylephrine- and Akt-induced cardiac hypertrophy. Metformin and 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside were used to activate AMPK in neonatal rat cardiac myocytes. Activation of AMPK significantly decreased protein synthesis induced by phenylephrine treatment or by expression of constitutively active Akt. Activation of AMPK also resulted in decreased p70S6 kinase phosphorylation and increased phosphorylation of eEF2, suggesting that inhibition of protein synthesis involves the eEF2 kinase/eEF2 axis and/or the p70S6 kinase pathway. Together, our data suggest that the inhibition of protein synthesis by pharmacological activation of AMPK may be a key regulatory mechanism by which hypertrophic growth can be controlled.
Design of a High Temperature Workstation for the Selective Laser Sintering Process (2018)

The Selective Laser Sintenng ProcesshassuccessfuUy proven its viability for sinteringlow meltin~iPointmeta1s,polymers, and.ceramic binder mixtures.A High'femperatureWorkstation utilizing a high-power laser.iscurrently beingdesignedtQstudythefeasibilityof this process for highmelting-point>lllaterials.Aworkingqhamberand powder handlin~system were designedtoacceptpowerfrollla 1.1 kW laser.A powder preheating systelll.andgasflOWCOlltr01.systemregulate.the chamber.environment.A process control computeraut01l1ates all aspects of the High Temperature Workstation.At the cOlllpletiQnoftheproject, we expect to have an automated academic test-bed to control and monitor all process parameters associated.with high-temperature Selective LaserSintering.
The Macular Photostress Test in Diabetic Retinopathy and Age-Related Macular Degeneration (1990)

We propose the macular photostress test for the evaluation of macular function in the office setting. Eighty eyes were tested and divided into four diagnostic categories: background diabetic retinopathy, diabetic macular edema, age-related macular degeneration, and normal. The recovery times for the eyes with age-related macular degeneration were longer than for eyes with macular edema (P = .03). Age-matched patients with age-related macular degeneration had longer recovery times than did those without age-related macular degeneration (P = .0001). A possible explanation is that the prolonged recovery time in the eyes with age-related macular degeneration reflects that the anatomic lesion is located in the retinal pigment epithelium-photoreceptor complex. In comparison, the eyes with macular edema, whose lesion is in the inner retina and not the retinal pigment epithelium, show a less-prolonged recovery time than the eyes with age-related macular degeneration.
<title>Relative variation of stress-optic coefficient with wavelength in fused silica and calcium fluoride</title> (1999)

Birefringence in refractive components such as lenses has become an increasingly serious problem in semiconductor lithography as exposure wavelength decreases. Most measurements of birefringence are made with visible light but the light used for photolithography is in the UV and deep UV spectral regions. Measurements of the relative variation of stress-optic constants have been made for fused silica and calcium fluoride, the two primary transmissive optical materials used by this industry.
Urea-Formaldehyde Film-Forming Compositions (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUrea-Formaldehyde Film-Forming CompositionsT. S. Hodgins and A. G. HoveyCite this: Ind. Eng. Chem. 1941, 33, 4, 512–515Publication Date (Print):April 1, 1941Publication History Published online1 May 2002Published inissue 1 April 1941https://pubs.acs.org/doi/10.1021/ie50376a016https://doi.org/10.1021/ie50376a016research-articleACS PublicationsRequest reuse permissionsArticle Views92Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Male and Female Flowers of the Dioecious Plant Sorrel Show Different Patterns of MADS Box Gene Expression (1995)

Charles Ainsworth, Susan Crossley, Vicky Buchanan-Wollaston, Madan Thangavelu, John Parker, Male and Female Flowers of the Dioecious Plant Sorrel Show Different Patterns of MADS Box Gene Expression, The Plant Cell, Vol. 7, No. 10 (Oct., 1995), pp. 1583-1598
[Antiinflammatory activity of extracts and fractions obtained from Physalis peruviana L. calyces]. (2007)

The antiinflammatory activity attributed to Physalis peruviana calyces was confirmed and validated its use in folk medicine. Fractions responsible for the antiinflammatory action were identified and seem promising for phytomedicinal development. Further studies are needed to isolate and identify the active constituents of these fractions as well as to ascertain the mechanisms involved in the antiinflammatory effect.
European Court of Human Rights (1997)

European Court of Human Rights Get access Ahmed v. Austria Ahmed v. Austria Search for other works by this author on: Oxford Academic Google Scholar International Journal of Refugee Law, Volume 9, Issue 2, April 1997, Pages 279–291, https://doi.org/10.1093/ijrl/9.2.279 Published: 01 April 1997
Preventing Nephropathy Induced by Contrast Medium (2006)

A 71-year-old man with type 2 diabetes and hypertension is referred for coronary angiography. Medications include metformin and a thiazide. Before the angiogram, his serum creatinine level is 1.8 mg per deciliter (160 μmol per liter), yielding an estimated glomerular filtration rate of 40 ml per minute per 1.73 m2 of body-surface area. What can be done to reduce the risk that an angiographic contrast agent will worsen his kidney function?
Permutation Tests for Linear Models (2001)

Several approximate permutation tests have been proposed for tests of partial regression coefficients in a linear model based on sample partial correlations. This paper begins with an explanation and notation for an exact test. It then compares the distributions of the test statistics under the various permutation methods proposed, and shows that the partial correlations under permutation are asymptotically jointly normal with means 0 and variances 1. The method of Freedman & Lane (1983) is found to have asymptotic correlation 1 with the exact test, and the other methods are found to have smaller correlations with this test. Under local alternatives the critical values of all the approximate permutation tests converge to the same constant, so they all have the same asymptotic power. Simulations demonstrate these theoretical results.
GazeDirector: Fully Articulated Eye Gaze Redirection in Video (2018)

Abstract We present GazeDirector, a new approach for eye gaze redirection that uses model‐fitting. Our method first tracks the eyes by fitting a multi‐part eye region model to video frames using analysis‐by‐synthesis, thereby recovering eye region shape, texture, pose, and gaze simultaneously. It then redirects gaze by 1) warping the eyelids from the original image using a model‐derived flow field, and 2) rendering and compositing synthesized 3D eyeballs onto the output image in a photorealistic manner. GazeDirector allows us to change where people are looking without person‐specific training data, and with full articulation, i.e. we can precisely specify new gaze directions in 3D. Quantitatively, we evaluate both model‐fitting and gaze synthesis, with experiments for gaze estimation and redirection on the Columbia gaze dataset. Qualitatively, we compare GazeDirector against recent work on gaze redirection, showing better results especially for large redirection angles. Finally, we demonstrate gaze redirection on YouTube videos by introducing new 3D gaze targets and by manipulating visual behavior.
Cell Biology of T Cell Receptor Expression and Regulation (2017)

T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains that recognize peptide antigens associated with major histocompatibility complex molecules expressed on the surface of antigen-presenting cells. TCRαβ subunits are associated with the CD3 complex formed by the γ, δ, ε, and ζ subunits, which are invariable and ensure signal transduction. Here, we review how the expression and function of TCR complexes are orchestrated by several fine-tuned cellular processes that encompass (a) synthesis of the subunits and their correct assembly and expression at the plasma membrane as a single functional complex, (b) TCR membrane localization and dynamics at the plasma membrane and in endosomal compartments, (c) TCR signal transduction leading to T cell activation, and (d) TCR degradation. These processes balance each other to ensure efficient T cell responses to a variety of antigenic stimuli while preventing autoimmunity.
Robust Controller Design for IG Driven by Variable-Speed in WECS Using μ-Synthesis (2013)

This paper presents robust controller design for a wind-driven induction generator system using structured singular value ( -synthesis) method. The controller was designed for a static synchronous compensator (STATCOM) and a variable blade pitch angle in a wind energy conversion system (WECS) in order to achieve the required voltage and mechanical power control. The results indicated that this controller offers satisfactory damping characteristics for closed loop systems. Effects of various system disturbances on dynamic performance of the WECS were evaluated in this study by a time domain nonlinear simulation and compared with the output feedback controller. The proposed designed controller showed to be more effective in regulating the load voltage and stabilizing the generator rotating speed for WECS.
Use of an adjustable, transportable, radiolucent spinal immobilization device in the comprehensive management of cervical spine instability (1996)

In this report the authors describe a device that consists of a transportable, radiolucent board that couples to a standard halo head ring. The board provides continuous cervical spine immobilization during all phases of acute medical treatment of cervical spine instability, including closed reduction, transport, radiographic imaging, and operative procedures. By combining the advantages of several existing systems, this immobilization device facilitates and improves the safety of comprehensive acute management of cervical spinal instability by eliminating the need for patient transfer from stretcher to radiography machine to operating table. Its radiolucent construction and its compatibility with standard operating tables allow unencumbered surgical access and ample room for biplanar fluoroscopy, thereby also facilitating operative procedures, particularly the placement of internal spinal fixation.
Differences in carcass grading schemes used in the USA, Japan and Australia (2004)

Over the past 30 years there has been increasing pressure for the establishment of a beef, quality grading system in Australia. During this time, many and varied options have been proposed and comparisons have often been made with the United States Department of Agriculture (USDA) and the Japanese Meat Grading Association (JMGA) systems. Australia has now developed a grading system that is driven by the consumer — Meat Standards Australia (MSA). Although some years (70+) behind the USDA, the Australian model has been scientifically proven to identify product that can achieve a guaranteed level of satisfaction to the consumer. While this paper evaluates the 3 systems and their specific operations, both the USDA and JMGA systems are compared with the potential performance of the MSA system applied on a cut by grade by cooking method basis.
Nanoparticles (2011)

This Chapter reports on the advances in 2010 in the field of nanoparticles.
Perinatal chronic hypoxia induces cortical inflammation, hypomyelination, and peripheral myelin-specific T cell autoreactivity (2015)

pCH is an important risk factor for brain injury and long-term morbidity in children, occurring during the developmental stages of neurogenesis, neuronal migration, and myelination. We show that a rodent model of pCH results in an early decrease in mature myelin. Although pCH does increase progenitor oligodendrocytes in the developing brain, BrdU labeling revealed a loss in dividing progenitor oligodendrocytes, indicating a defect in mature cell replacement and myelinogenesis. Mice continued to exhibited hypomyelination, concomitant with long-term impairment of motor function, weeks after cessation of pCH. The implication of a novel neuroimmunologic interplay, pCH also induced a significant egress of infiltrating CD4 T cells into the developing brain. This pCH-mediated neuroinflammation included oligodendrocyte-directed autoimmunity, with an increase in peripheral myelin-specific CD4 T cells. Thus, both the loss of available, mature, myelin-producing glial cells and an active increase in autoreactive, myelin-specific CD4 T cell infiltration into pCH brains may contribute to early pCH-induced hypomyelination in the developing CNS. The elucidation of potential mechanisms of hypoxia-driven autoimmunity will expand our understanding of the neuroimmune axis during perinatal CNS disease states that may contribute to long-term functional disability.
GDOP and the Cramer-Rao bound (2002)

The GDOP is frequently thought of as a number signifying the effect of satellite geometry on computed position. More generally, it is well known that the GDOP matrix is the covariance of the linearized least squares errors in estimating position and bias from pseudoranges with unit variances. However a much stronger statistical interpretation is possible. In this paper we explore the relationship between the GDOP matrix and the Cramer-Rao bound of classical statistical point estimation. We also detail an interpretation of GDOP made in earlier work. In the first part of the paper we show that the GDOP matrix is actually the Cramer-Rao lower bound on estimates of position and bias given that the pseudorange errors are Gaussian distributed. In light of recent work indicating that pseudoranges not affected by SA are likely not Gaussian, we discuss generalization of this result to symmetric non-Gaussian pseudorange errors. In the second part of the paper, the GDOP is interpreted in terms of covariance about the average line of sight vector. This interpretation is used to compare ranging systems with pseudoranging systems. It is demonstrated that ranging systems are inherently more accurate, given the same geometry and measurement variances. Conditions under which the two systems are equivalent are derived. The role of the clock bias in this relationship is detailed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Smart$^2$ Speaker Blocker: An Open-Source Privacy Filter for Connected Home Speakers (2019)

The popularity and projected growth of in-home smart speaker assistants, such as Amazon's Echo, has raised privacy concerns among consumers and privacy advocates. Notable questions regarding the collection and storage of user data by for-profit organizations include: what data is being collected and how is it being used, who has or can obtain access to such data, and how can user privacy be maintained while providing useful services. In addition to concerns regarding what the speaker manufacturer will do with your data, there are also more fundamental concerns about the security of these devices, third-party plugins, and the servers where they store recorded data. To address these privacy and security concerns, we introduce an intermediary device to provide an additional layer of security, which we call the \textit{smart, smart speaker blocker} or Smart\textsuperscript{2} for short. By intelligently filtering sensitive conversations, and completely blocking this information from reaching a smart speaker's microphone(s), the Smart$^2$ Speaker Blocker is an open-source, network-local (offline) smart device that provides users with decisive control over what data leaves their living room.
ARTIFICIAL SUNLIGHT (1931)

Director Nela Park Research Laboratories. Published by D. Van Nostrom & Co., Inc., New York City. 254 pages, 65 illustrations. Price, $3.75. 1930.