gebhart/patrepeval huggingface dataset:
Characterization of Polyurethane Foam Dielectric Strength (2008)

Internal flashovers in hollow insulation systems can produce serious damage. Frequently, SF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> or N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> is used to eliminate this problem, but possible gas leakage may endanger the insulation. This paper proposes the use of polyurethane foams to fill the hollow spaces in insulation systems. Thus far, few publications deal with the dielectric properties of foams. This paper demonstrates the dielectric strength of three different foams which are investigated using ac and lightning impulse voltages under different humidity and temperature conditions. The results show that polyurethane foams have 2-3 times better dielectric strength than air. The breakdown strength decreases with the thickness of the foam; temperature and humidity have negligible effects on the breakdown voltage. The major parameter is the size of the voids in the foam. Reducing the size of the voids increases the breakdown strength. This can be achieved by improving the manufacturing technology.
Comparative analysis of the sequences and structures of HIV‐1 and HIV‐2 proteases (1991)

The different isolates available for HIV-1 and HIV-2 were compared for the region of the protease (PR) sequence, and the variations in amino acids were analyzed with respect to the crystal structure of HIV-1 PR with inhibitor. Based on the extensive homology (39 identical out of 99 residues), models were built of the HIV-2 PR complexed with two different aspartic protease inhibitors, acetylpepstatin and a renin inhibitor, H-261. Comparison of the HIV-1 PR crystal structure and the HIV-2 PR model structure and the analysis of the changes found in different isolates showed that correlated substitutions occur in the hydrophobic interior of the molecule and at surface residues involved in ionic or hydrogen bond interactions. The substrate binding residues of HIV-1 and HIV-2 PRs show conservative substitutions of four residues. The difference in affinity of HIV-1 and HIV-2 PRs for the two inhibitors appears to be due in part to the change of Val 32 in HIV-1 PR to Ile in HIV-2 PR.
Influence of Stationary Phase Chemistry on Shape Recognition in Liquid Chromatography (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of Stationary Phase Chemistry on Shape Recognition in Liquid ChromatographyLane C. Sander and Stephen A. WiseCite this: Anal. Chem. 1995, 67, 18, 3284–3292Publication Date (Print):September 15, 1995Publication History Published online1 May 2002Published inissue 15 September 1995https://pubs.acs.org/doi/10.1021/ac00114a027https://doi.org/10.1021/ac00114a027research-articleACS PublicationsRequest reuse permissionsArticle Views729Altmetric-Citations157LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Selected Public Health Bibliography (1937)

A Selected Public Health Bibliography Raymond S. Patterson CopyRight https://doi.org/10.2105/AJPH.27.4.423 Published Online: August 29, 2011
A phase I study of a yeast-based therapeutic cancer vaccine, GI-6301, targeting brachyury in patients with metastatic carcinoma. (2014)

e14026 Background: Saccharomyces cerevisiae has been genetically modified to express Brachyury (Br) protein and developed under a CRADA with GlobeImmune/NCI as a heat-killed therapeutic cancer vaccine (GI-6301). Br is a member of the T-box family of transcription factors, characterized by a highly conserved DNA-binding domain designated as T-domain. Expression of Br confers on epithelial tumor cells a mesenchymal phenotype, as well as migratory and invasive abilities and enhances treatment resistance. Preclinical work has demonstrated Br specific T cells can lyse human cancer cells expressing Br in an MHC restricted fashion. Methods: This phase I study (NCT01519817) enrolled 27 patients with advanced cancers. Patients received escalating doses of vaccine every 2 weeks x 7 and then monthly with restaging scans every 2 months while on study. The primary endpoint was safety. Tumor-associated antigen immune responses were also analyzed. Immune response was measured by flow-cytometry intracellular staining (ICS) of CD4 and CD8 T lymphocytes for the cytokines interferon gamma, tumor necrosis factor, and interleukin 2. Results: Treatment was well tolerated with 191 vaccine cycles given. There were no grade 3 or greater adverse events related to therapy. Only 7 cycles were associated with transient grade 2 adverse events. PBMC were available from 21 pts for immune response analysis with 7 demonstrating a Br-specific CD8+ and/or CD4+ T cell response post vs. pre-vaccination. Median time on study was 74 days (range). A patient with metastatic colon cancer had stable disease for 15 months. Conclusions: A phase I study with GI-6301 vaccine demonstrated safety and generated immune response in some patients. These results demonstrate, for the first time in humans, that a transcription factor can be targeted immunologically via vaccination. Clinical trial information: NCT01519817.
Cholinesterase Inhibition by Derivatives of 2-Amino-4,6-Dimethylpyridine (1997)

Derivatives of 2-amino-4,6-dimethylpyridine, aryl(alkyl)carboxamides, thiocarbamides and amidra-zones, already known for their anti-inflammatory properties, were found to be moderately active inhibitors of acetyl and butyrylcholinesterase. Quantitative structure-activity relationships showed that the binding affinity was enhanced by the following structural modifications: (1) increase in molecular volume, (2) decrease in the energy of the lowest unoccupied molecular orbital, (3) insertion of a methylene group between the amide carbonyl and the aromatic ring, (4) replacement of the amide oxygen by sulfur. The affinity remained, however, weaker than that of the specific inhibitor 9-amino-1,2,3,4-tetrahydroacridine (tacrine). The association of anti-inflammatory and cholinesterase inhibiting activities within the same compound may prove useful for the treatment of Alzheimer's disease.
Metabolic profiling of pteridines for determination of potential biomarkers in cancer diseases (2011)

Cancer disease is the second leading cause of death in the world. Epidemiology data indicate that early diagnosis of a tumour increases a patient's chance of recovery. Biomarkers are effective instruments which can potentially lead to precancer screening or precancer diagnosis and may provide useful information on the cancer type and the disease's stage of progression. The analysis of new biomarkers for cancer is currently a popular area of study in clinical and cancer research. Pteridines are a class of potential cancer biomarkers. The monitoring levels of pteridines may have prospective value for controlling the course of the malignant process. This review describes the functional employment of pteridines, as biomarkers, in cancer diagnosis. It also contains the description of application of analytical techniques such as high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) used for pteridine analysis.
Modeling and Simulation of Two-Dimensional MOEMS Scanning Mirror (2008)

Two-dimensional scanning mirror is a new kind of deflection scanning device based on micro-optical-electro-mechanical system (MOEMS) technology, which has great advantages over the conventional scanning mechanisms with small volume, low power consumption and high scanning frequency. A two-dimensional MOEMS scanning mirror is presented and the dynamic model of the two degrees of freedom (DOF) vibration system is established. Equations of stiffnesses and scanning frequencies of the system are deduced, as well as the maximum deflection angles of the two DOF. The operational modes, harmonic response and stress distribution of the system are simulated using the finite element method and the results all meet the requirement of design. It is concluded that the design and modeling of the two-dimensional MOEMS scanning mirror are correct and effective.
Differential biotransformation of the enantiomers of isoidide dinitrate in isolated rat aorta (1989)

Previous studies have demonstrated that the D-enantiomer of isoidide dinitrate (IIDN) is 10-fold more potent than the L-enantiomer for relaxation and cyclic GMP accumulation in isolated rat aorta. To test whether preferential biotransformation of D-IIDN to a species that activates guanylate cyclase is the basis for this observed enantioselectivity, paired segments of rat aorta were exposed to D- and L-IIDN and the tissue accumulation of the parent compound and the formation of their respective metabolites (D- and L-isoidide mononitrate, IIMN) were determined. The extent of relaxation of rat aorta following exposure to 2 microM D-IIDN was greater than that by L-IIDN over a 5-minute time course, and this was associated with a higher rate of D-IIDN biotransformation to D-IIMN at all time points. In addition, the rate of D-IIDN biotransformation was greater than that of L-IIDN at most IIDN concentrations tested. By contrast, the amount of D- and L-IIDN in the tissue was the same at all time points and concentrations tested, indicating that selective uptake of D-IIDN into blood vessels did not occur. When tissues were made tolerant to organic nitrate-induced relaxation by treatment with a high concentration of glyceryl trinitrate, the biotransformation of both D- and L-IIDN was attenuated. This suggests that mechanism-based biotransformation may be affected during tolerance development. Furthermore, the association of preferential D-IIDN biotransformation with its greater potency for vasodilation and cyclic GMP accumulation suggests than an enantioselective site for biotransformation is an important component of organic nitrate-induced vasodilation.
Fundamentals of cone beam computed tomography for a prosthodontist (2015)

Cone beam computed tomography (CBCT, also referred to as C-arm computed tomography [CT], cone beam volume CT, or flat panel CT) is a medical imaging technique of X-ray CT where the X-rays are divergent, forming a cone.[1] CBCT systems have been designed for imaging hard tissues of the maxillofacial region. CBCT is capable of providing sub-millimeter resolution in images of high diagnostic quality, with short scanning times (10-70 s) and radiation dosages reportedly up to 15-100 times lower than those of conventional CT scans. Increasing availability of this technology provides the dental clinician with an imaging modality capable of providing a three-dimensional representation of the maxillofacial skeleton with minimal distortion. The aim of this article is to sensitize the Prosthodontist to CBCT technology, provide an overview of currently available maxillofacial CBCT systems and review the specific application of various CBCT display modes to clinical Prosthodontic practice. A MEDLINE search for relevant articles in this specific area of interest was conducted. The selected articles were critically reviewed and the data acquired were systematically compiled.
Body axis determination during early development in amphibians (1992)

The specification of the main axes of the body is a phenomenon based on cell communication and is among the early crucial events of embryonic development. Upon fertilization, the amphibian egg reorganizes its cytoplasmic content, leading to the establishment of the future dorsal-ventral axis of the body. Heterogeneous distribution of maternal components confers cellular regionalization after only a few mitoses. Development up to the 4000-cell stage proceeds almost entirely on maternal materials, and during this period there is remodeling of the chromatin to set up specific gene expression in various regions of the embryo. The zygote at this stage has already undertaken cellular interactions leading to mesoderm formation and regionalization. Dorsal mesodermal components then induce the formation of the Spemann's organizer, a structure directly involved in the specification of the anterior-posterior axis of the embryo (head to tail). Molecular analysis of these phenomena has allowed the identification of growth-factor-like and transcription-factor-like proteins that have characteristics typical of specification factors. We will review the recent advances on these molecules and will also discuss the putative role of retinoic acid as a posteriorizing agent.
Quantification of endotoxin inhibition in serum and plasma using a turbidimetric LAL assay. (1985)

A modified Limulus amebocyte lysate (LAL) test was developed which quantifies the inhibition associated with lipopolysaccharide (LPS) in serum and plasma. The assay utilized the LR50 value to determine relative inhibition. The LR50, measured in ng/ml, represented the concentration of endotoxin needed to elicit a turbidimetric response equal to 50% of the maximum above the control (no added endotoxin). The LR50 concept was used to compare plasma and serum from a normal donor population. Plasma LR50 values ranged from 115 to 5000 ng/ml, while serum samples ranged from 48 to 615 ng/ml. Endotoxin in saline measured in a similar manner yielded values averaging 0.07 ng/ml (LAL sensitivity). Various means to remove inhibition were also tested by this method. Heating, dilution, and chloroform extraction of serum were all found to be efficient in removing inhibition. Although no direct attempt was made to elucidate the biochemical nature of the inhibitor(s) present in serum and plasma, the results presented were consistent with other studies and indicate the involvement of a heat labile component(s). The LR50 may provide a tool for the elaboration of these components. It also was suggested that LR50 may be the best in vitro indicator of the overall ability of serum or plasma to neutralize endotoxin.
Differences in regenerated silk fibroin prepared with different solvent systems: From structures to conformational changes (2015)

ABSTRACT Dissolution is an important part of silk fibroin (SF) reprocessing, and it is the only way to process it into films, gels, porous scaffold materials, and electrostatic spinning silk fibers. There are a variety of dissolution systems used to dissolve SF. However, few studies have focused on the differences between these different solvent systems. The dissolution of SF with different solvent systems was investigated in this study. Regenerated silk fibroin (RSF) solutions and films were characterized by dynamic light scattering, Fourier transform infrared spectroscopy, differential scanning calorimetry, X‐ray diffraction, and scanning electron microscopy. The results show that the RSF film structures changed with the solvent system, especially LiBr–H 2 O. The characterization proved that the random coil did not change into a β‐sheet structure during film formation, and this indicated that its crystal structure and thermal stability was different from others. Interestingly, the differences in the morphologies of all of the RSF films prepared with different solvents were outstanding. Because the mechanism and force of the ion in the solvent systems were different, the SF molecule was hydrolyzed differently in individual solvent systems and produced different hydrolyzed SF molecular chains. These chains had different self‐assembly processes and would lead to RSF products with different microstructures and properties. This suggests that a suitable solvent should be chosen for different uses. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41959.
Myogenic differentiation of mesenchymal stem cells co-cultured with primary myoblasts (2010)

TE (tissue engineering) of skeletal muscle is a promising method to reconstruct loss of muscle tissue. This study evaluates MSCs (mesenchymal stem cells) as new cell source for this application. As a new approach to differentiate the MSCs towards the myogenic lineage, co-cultivation with primary myoblasts has been developed and the myogenic potential of GFP (green fluorescent protein)-transduced rat MSC co-cultured with primary rat myoblasts was assessed by ICC (immunocytochemistry). Myogenic potential of MSC was analysed by ICC, FACS and qPCR (quantitative PCR). MSC-myoblast fusion phenomena leading to hybrid myotubes were evaluated using a novel method to evaluate myotube fusion ratios based on phase contrast and fluorescence microscopy. Furthermore, MSC constitutively expressed the myogenic markers MEF2 (myogenic enhancer factor 2) and α-sarcomeric actin, and MEF2 expression was up-regulated upon co-cultivation with primary myoblasts and the addition of myogenic medium supplements. Significantly higher numbers of MSC nuclei were involved in myotube formations when bFGF (basic fibroblast growth factor) and dexamethasone were added to co-cultures. In summary, we have determined optimal co-culture conditions for MSC myogenic differentiation up to myotube formations as a promising step towards applicability of MSC as a cell source for skeletal muscle TE as well as other muscle cell-based therapies.
Biohashing with fingerprint spectral minutiae (2013)

Abstract: In recent years, the interest in human authentication has been increasing. Biometrics are one of the easy authentication schemes, however, security and privacy problems limit their widespread usage. Following the interest in privacy protecting biometric authentication, template protection schemes for biometric modalities has in-creased significantly in order to cope with security and privacy issues. BioHashing, which is based on transforming the biometric template using pseudo-random projec-tions that are generated using a user-specified key or token, has received much atten-tion as it improves verification accuracies over using only the biometric data, allows template revocation and preserves privacy. In our work, we develop a new BioHashing scheme for fingerprints. A fixed-length feature vector is required in order to design a BioHashing scheme. In the literature, most of the studies on fingerprint BioHashing uses features extracted from fingerprint texture. On the other hand, our new BioHash-ing scheme is based on minutia based feature vectors. We use the spectral minu-tiae representation for obtaining a fixed-length feature vector for a fingerprint sample. Then, we use a random projection matrix, which is generated from user’s key/token, in order to generate a BioHash vector. We propose to randomly project each column of the spectral minutiae feature matrix via a single matrix which allows fast bit string extraction and adaptive quantization. Experiments on FVC2002 databases show the promise of the proposed system for fast and secure verification. 1
The antimicrobial potential of honey from United Arab Emirates on some microbial isolates. (2005)

Honey prevents growth of the isolates and inhibits their growth when honey was added to growing culture. The therapeutic period of honey and recovery growth of inhibited isolates necessitates adjustment of honey doses according to type of isolate and grade of growth.
Contact dermatitis from propolis: role of gastrointestinal absorption (1987)

Contact DermatitisVolume 16, Issue 1 p. 48-48 Contact dermatitis from propolis: role of gastrointestinal absorption G. Trevisan, G. Trevisan Department of Dermatology, Cattinara Hospital, Strada di Fiume, 34149 Trieste, ItalySearch for more papers by this authorF. Kokelj, F. Kokelj Department of Dermatology, Cattinara Hospital, Strada di Fiume, 34149 Trieste, ItalySearch for more papers by this author G. Trevisan, G. Trevisan Department of Dermatology, Cattinara Hospital, Strada di Fiume, 34149 Trieste, ItalySearch for more papers by this authorF. Kokelj, F. Kokelj Department of Dermatology, Cattinara Hospital, Strada di Fiume, 34149 Trieste, ItalySearch for more papers by this author First published: January 1987 https://doi.org/10.1111/j.1600-0536.1987.tb02626.xCitations: 8AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume16, Issue1January 1987Pages 48-48 RelatedInformation
Identification and characterization of mitochondria autoantigens in progressive systemic sclerosis: identity with the 72,000 dalton autoantigen in primary biliary cirrhosis. (1986)

Sera from eight out of 62 (14.5%) patients with progressive systemic sclerosis (PSS) reacted by immunoblotting with a 72,000 dalton antigen and one, a patient with concomitant primary biliary cirrhosis (PBC), reacted with the 72,000 dalton and a 47,000 dalton antigen. Reactivity with these antigens was not seen with any of 111 control sera. The antigens with minor variations in m.w. were present in a variety of cultured cells and tissue homogenates from different species. Subcellular fractionation studies localized the antigens to the mitochondria. Of 19 sera from patients with other diseases selected for immunofluorescence staining for anti-mitochondria autoantibody, nine reacted with the 72,000 dalton antigen, seven reacted with both the 72,000 and 47,000 dalton antigens, and three reacted with the 47,000 dalton antigen. These results show that serum reactivity with the 72,000 dalton and 47,000 dalton mitochondria autoantigens is found with some patients with PSS. Because mitochondria autoantibodies that are reactive with the 72,000 dalton and 47,000 dalton polypeptides are also found in patients with PBC, the present finding provides additional support for the association of PSS with PBC. Prior absorption of rat liver homogenate with PBC sera removed PSS serum reactivity with a 63,000 dalton antigen, the equivalent 72,000 dalton antigen in rodents, and vice versa, showing that both PBC and PSS sera recognize the same antigen.