gebhart/patrepeval huggingface dataset:
Reducing Qubit Requirements while Maintaining Numerical Precision for the Variational Quantum Eigensolver: A Basis-Set-Free Approach (2021)

We present a basis-set-free approach to the variational quantum eigensolver using an adaptive representation of the spatial part of molecular wave functions. Our approach directly determines system-specific representations of qubit Hamiltonians while fully omitting globally defined basis sets. In this work, we use directly determined pair-natural orbitals on the level of second-order perturbation theory. This results in compact qubit Hamiltonians with high numerical accuracy. We demonstrate initial applications with compact Hamiltonians on up to 22 qubits where conventional representation would for the same systems require 40-100 or more qubits. We further demonstrate reductions in the quantum circuits through the structure of the pair-natural orbitals.
Developing new neurophysiological signatures of general anesthesia induced loss of consciousness (2009)

General anesthesia is currently defined in the context of its use in clinical care [1]. The mechanism by which anesthetic drugs induce general anesthesia is not well understood. There is therefore a need to incorporate neurophysiological characterizations into the definition and understanding of anesthesia. Distinct patterns in the electroencephalogram have been associated with anesthesia-induced loss of consciousness [2-4] and are used as part of protocols to monitor integrity of brain function [5]. However, the transition to unconsciousness during a gradual induction of general anesthesia has not been studied systematically.
Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site (2000)

CTL directed against the Moloney murine leukemia virus (MuLV) epitope SSWDFITV recognize Moloney MuLV-induced tumor cells, but do not recognize cells transformed by the closely related Friend MuLV. The potential Friend MuLV epitope has strong sequence homology with Moloney MuLV and only differs in one amino acid within the CTL epitope and one amino acid just outside the epitope. We now show that failure to recognize Friend MuLV-transformed tumor cells is based on a defect in proteasome-mediated processing of the Friend epitope which is due to a single amino acid substitution (N-->D) immediately flanking the C-terminal anchor residue of the epitope. Proteasome-mediated digestion analysis of a synthetic 26-mer peptide derived from the Friend sequence shows that cleavage takes place predominantly C-terminal of D, instead of V as is the case for the Moloney MuLV sequence. Therefore, the C terminus of the epitope is not properly generated. Epitope-containing peptide fragments extended with an additional C-terminal D are not efficiently translocated by TAP and do not show significant binding affinity to MHC class I-Kb molecules. Thus, a potential CTL epitope present in the Friend virus sequence is not properly processed and presented because of a natural flanking aspartic acid that obliterates the correct C-terminal cleavage site. This constitutes a novel way to subvert proteasome-mediated generation of proper antigenic peptide fragments.
Frequency‐modulated radiofrequency pulses in spin‐echo and stimulated‐echo experiments (1987)

Abstract Frequency‐modulated of pulses based on a linear frequency sweep are studied experimentally in spin‐echo and stimulated‐echo sequences. It turns out that these FM pulses generate a quadratic phase perpendicular to the selected slice and that the quadratic phases of the FM pulses in a spin‐echo or stimulated‐echo sequence may compensate each other if sweep velocity and gradients are suitably chosen. For a complete rephasing, a formula is given and supported by measured slice profiles. Slice profiles of excellent rectangularity are obtained. Finally, it is shown that with this technique images can be obtained using pulses of increased bandwidth and reduced peak power compared with the AM situation. © 1987 Academic Press, Inc.
3-Fluoroazetidinecarboxylic Acids and <i>trans,trans-</i>3,4-Difluoroproline as Peptide Scaffolds: Inhibition of Pancreatic Cancer Cell Growth by a Fluoroazetidine Iminosugar (2015)

Reverse aldol opening renders amides of 3-hydroxyazetidinecarboxylic acids (3-OH-Aze) unstable above pH 8. Aze, found in sugar beet, is mis-incorporated for proline in peptides in humans and is associated with multiple sclerosis and teratogenesis. Aze-containing peptides may be oxygenated by prolyl hydroxylases resulting in potential damage of the protein by a reverse aldol of the hydroxyazetidine; this, rather than changes in conformation, may account for the deleterious effects of Aze. This paper describes the synthesis of 3-fluoro-Aze amino acids as hydroxy-Aze analogues which are not susceptible to aldol cleavage. 4-(Azidomethyl)-3-fluoro-Aze and 3,4-difluoroproline are new peptide building blocks. trans,trans-2,4-Dihydroxy-3-fluoroazetidine, an iminosugar, inhibits the growth of pancreatic cancer cells to a similar degree as gemcitabine.
Formation of concentration gradient and its application to DNA capillary electrophoresis (2000)

A new method to introduce the concentration gradient into the capillary has been developed and its application to DNA capillary electrophoresis is presented. The concentration gradient produced by mixing 5% w/v polyacrylamide-co-poly(N-dimethylacrylamide) (PAM-co-PDMA) solution and 1 x Tris/N-tris(hydroxymethyl)methyl-3-amino-propanesulfonic acid/EDTA (TT) + 5 M urea buffer was successfully achieved by using two programmable syringe pumps with strict control of dead volume, flow rate, and pressure balance. This method has the advantages of high stability, reproducibility, and versatility. The column with concentration gradient greatly improved the resolution, especially for the large DNA fragments, due to a decrease in band width broadening with time. A column containing 2-4% w/v gradient in four steps had a longer read length, shorter separation time and better resolution (after 380 base) than that of 4% w/v single concentration polymer solution. The number of steps in the gradient had almost no effect on the performance. The change in the average concentration by relocating the position of the same step gradient, i.e., a combination of different low concentration to high concentration polymer solution ratios, resulted in a different migration time, read length and resolution.
Digestion and Absorption of Protein (1978)

Postpartum depression (PPD) is common, disabling, and treatable. The strongest risk factor is a history of mood or anxiety disorder, especially having active symptoms during pregnancy. As PPD is one of the most common complications of childbirth, it is ...Read More
Beiträge zur Keramik hochfeuerfester Stoffe. l. Die Formen des Zirkondioxyds (1929)

Abstract 1. Bezüglich der verschiedenen Formen des ZrO 2 wird durch Verwendung von Spezialröntgenkameras festgestellt, daß das handelsübliche, bei 1200° C vorgeglühte Oxyd bei etwa 1000° C einen reversiblen Modifikationswechsel von monokliner Symmetrie in tetragonale durchmacht.
<i>ESCHERICHIA COLI</i> RHO FACTOR IS INVOLVED IN LYSIS OF BACTERIOPHAGE T4-INFECTED CELLS (1985)

A Rid (Rho interaction deficient) phenotype of bacteriophage T4 mutants was defined by cold-sensitive restriction (lack of plaque formation) on rho+ hosts carrying additional polar mutations in unrelated genes, coupled to suppression (plaque formation) in otherwise isogenic strains carrying either a polarity-suppressing rho or a multicopy plasmid expressing the rho+ allele. This suggests that the restriction may be due to lower levels of Rho than what is available to T4 in the suppressing strains.--Rid394 X 4 was isolated upon hydroxylamine mutagenesis and mapped in the t gene; other t mutants (and mot, as well as dda dexA double mutants) also showed a Rid phenotype. In liquid culture in strains that restricted plaque formation Rid394 X 4 showed strong lysis inhibition (a known t- phenotype) but no prolonged phage production (another well-known t- phenotype). This implies that when Rho is limiting the t mutant shuts off phage production at the normal time. Lysis inhibition was partially relieved, and phage production prolonged to varying extents depending on growth conditions in strains that allowed plaque formation. No significant effect on early gene expression were found. Apparently, both mutant (polarity-suppressing) and wild-type Rho can function in prolonging phage production and partially relieving lysis inhibition of Rid394 X 4 when present at a sufficiently high level, and Rho may play other role(s) in T4 development than in early gene regulation.
Effects of combined mechanical stimulation on the proliferation and differentiation of pre-osteoblasts (2011)

We observed how combined mechanical stimuli affect the proliferation and differentiation of pre-osteoblasts. For this research, a bioreactor system was developed that can simultaneously stimulate cells with cyclic strain and ultrasound, each of which is known to effectively stimulate bone tissue regeneration. MC3T3-E1 pre-osteoblasts were chosen for bone tissue engineering due to their osteoblast-like characteristics. 3-D scaffolds were fabricated with polycaprolactone and poly-L-lactic acid using the salt leaching method. The cells were stimulated by the bioreactor with cyclic strain and ultrasound. The bioreactor was set at a frequency of 1.0 Hz and 10 % strain for cyclic strain and 1.0 MHz and 30 mW/cm(2) for ultrasound. Three experimental groups (ultrasound, cyclic strain, and combined stimulation) and a control group were examined. Each group was stimulated for 20 min/day. Mechanical stimuli did not affect MC3T3-E1 cell proliferation significantly up to 10 days when measured with the cell counting kit-8. However, gene expression analysis of collagen type-I, osteocalcin, RUNX2, and osterix revealed that the combined mechanical stimulation accelerated the matrix maturation of MC3T3-E1 cells. These results indicate that the combined mechanical stimulation can enhance the differentiation of pre-osteoblasts more efficiently than simple stimuli, in spite of no effect on cell proliferation.
Linear scalable space-time codes: tradeoff between spatial multiplexing and transmit diversity (2003)

Using a class of recently proposed linear scalable space-time codes, we demonstrate the tradeoff between spatial multiplexing and transmit diversity for Rayleigh and Ricean flat fading. The codes are able to use transmit diversity jointly in combination with spatial multiplexing, and they achieve spatial and temporal diversity in Rayleigh and Rice fading environments. The frequency diversity of frequency selective channels can be utilized by combining the considered codes and OFDM. Simulation results for different scenarios show that a system consisting of the considered codes and decoder meets the requirements of future communication systems, e.g. it is possible to exploit high diversity factors and handle high rates with a reasonable and scalable complexity.
High Yield Chip-on-wafer Low Temperature Plasma Activated Bonding for III-V/Si Hybrid Photonic Integration (2019)

The bonding strength dependence on stress by the bowing of chips was investigated for the InP/Si chip-on-wafer plasma activated bonding. The high bonding strength of 20 MPa was achieved with tensile stress occurred by the strain-controlled interlayer between InP chips and Si substrates.
Impact of uniaxial strain and doping on oxygen diffusion in CeO2 (2014)

Doped ceria is an important electrolyte for solid oxide fuel cell applications. Molecular dynamics simulations have been used to investigate the impact of uniaxial strain along the <100> directions and rare-earth doping (Yb, Er, Ho, Dy, Gd, Sm, Nd, and La) on oxygen diffusion. We introduce a new potential model that is able to describe the thermal expansion and elastic properties of ceria to give excellent agreement with experimental data. We calculate the activation energy of oxygen migration in the temperature range 900-1900 K for both unstrained and rare-earth doped ceria systems under tensile strain. Uniaxial strain has a considerable effect in lowering the activation energies of oxygen migration. A more pronounced increase in oxygen diffusivities is predicted at the lower end of the temperature range for all the dopants considered.
Wisconsin and Other Instrumentation for Posterior Spinal Fusion (1988)

In idiopathic scoliosis, the Wisconsin system is as safe as a Harrington rod and nearly as strong as a Luque construct. The installation is relatively easy. Sagittal curves can be preserved while correcting the scoliosis by contouring the rods and fixing them to the spine in a segmental fashion. The Wisconsin system is currently the instrumentation of choice at the authors' clinic for routine idiopathic scoliosis. The quest for the ideal spinal instrumentation system will probably never end. Further improvements on the current systems will inevitably appear, and new concepts will be developed. Spine surgeons will continue to be faced with the need to compare the advantages and disadvantages of different systems.
Polymer Nanowrinkles with Continuously Tunable Wavelengths (2013)

This paper describes a parallel method to generate polymer nanowrinkles over large areas with wavelengths that were continuously tuned down to 30 nm. Reactive ion etching using fluorinated gases was used to chemically treat thermoplastic polystyrene films, which resulted in a stiff skin layer. Upon heating, the treated thermoplastic, microscale, and nanoscale wrinkles were formed. We used variable-angle spectroscopic ellipsometry to characterize the thickness of the skin layer; this thickness could then be used to predict and control the nanowrinkle wavelength. Because the properties of these nanotextured polymer surfaces can be tuned over a large range of wrinkle wavelengths, they are promising for a broad range of applications, especially those that require large-area and uniform surface patterning.
Fast Third-Order Texture Filtering (2005)

Current programmable graphics hardware makes it possible to implement general convolution filters in fragment shaders for high-quality texture filtering, such as cubic filters (Bjorke 2004). However, several shortcomings are usually associated with these approaches: the need to perform many texture lookups and the inability to antialias lookups with mipmaps, in particular. We address these issues in this chapter for filtering with a cubic B-spline kernel and its first and second derivatives in one, two, and three dimensions.
Simplification and Generalization of Large Scale Data for Roads: A Comparison of Two Filtering Algorithms (1995)

This paper reports the results of an in-depth study which investigated two algorithms for line simplification and caricatural generalization (namely, those developed by Douglas and Peucker, and Visvalingam, respectively) in the context of a wider program of research on scale-free mapping. The use of large-scale data for man-designed objects, such as roads, has led to a better understanding of the properties of these algorithms and of their value within the spectrum of scale-free mapping. The Douglas-Peucker algorithm is better at minimal simplification. The large-scale data for roads makes it apparent that Visvalingam's technique is not only capable of removing entire scale-related features, but that it does so in a manner which preserves the shape of retained features. This technique offers some prospects for the construction of scale-free databases since it offers some scope for achieving balanced generalizations of an entire map, consisting of several complex lines. The results also suggest that it may be easier to formulate concepts and strategies for automatic segmentation of in-line features using large-scale road data and Visvalingam's algorithm. In addition, the abstraction of center lines may be facilitated by the inclusion of additional filtering rules with Visvalingam's algorithm.
Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice (2014)

The PTP4A3 gene is highly expressed in human colon cancer and often associates with enhanced metastatic potential. Genetic disruption of the mouse Ptp4a3 gene reduces the frequency of colon tumor formation in mice treated in a colitis-associated cancer model. In the current study, we have examined the role of Ptp4a3 in the tumor-initiating cell population of mouse colon tumors using an in vitro culture system. Tumors generated in vivo following AOM/DSS treatment were isolated, dissociated, and expanded on a feeder layer resulting in a CD133(+) cell population, which expressed high levels of Ptp4a3. Tumor cells deficient for Ptp4a3 exhibited reduced clonogenicity and growth potential relative to WT cells as determined by limiting dilution analysis. Importantly, expanded tumor cells from WT mice readily formed secondary tumors when transplanted into nude mice, while tumor cells without Ptp4a3 expression failed to form secondary tumors and thus were not tumorigenic. These results demonstrate that Ptp4a3 contributes to the malignant phenotype of tumor-initiating cells and supports its role as a potential therapeutic target to inhibit tumor self-renewal and metastasis.
An all-digital smart temperature sensor with auto-calibration in 65nm CMOS technology (2010)

A novel fully digital CMOS smart temperature sensor with auto-calibration circuit in 65nm CMOS technology is presented. The proposed auto-calibration circuit can greatly reduce the temperature calibration efforts, and therefore it is very suitable for on-chip dynamic thermal management applications. The power consumption of the proposed circuit is 55μW with 1.0V supply.
3D printed tricalcium phosphate bone tissue engineering scaffolds: effect of SrO and MgO doping on in vivo osteogenesis in a rat distal femoral defect model (2013)

The presence of interconnected macro pores is important in tissue engineering scaffolds for guided tissue regeneration. This study reports <i>in vivo</i> biological performance of interconnected macro porous tricalcium phosphate (TCP) scaffolds due to the addition of SrO and MgO as dopants in TCP. We have used direct three dimensional printing (3DP) technology for scaffold fabrication followed by microwave sintering. Mechanical strength was evaluated by scaffolds with 500 µm, 750 µm, and 1000 µm interconnected designed pore sizes. Maximum compressive strength of 12.01 ± 1.56 MPa was achieved for 500 µm interconnected designed pore size Sr-Mg doped scaffold. <i>In vivo</i> biological performance of the microwave sintered pure TCP and Sr-Mg doped TCP scaffolds was assessed by implanting 350 µm designed interconnected macro porous scaffolds in rat distal femoral defect. Sintered pore size of these 3D printed scaffolds were 311 ± 5.9 µm and 245 ± 7.5 µm for pure and SrO-MgO doped TCP scaffolds, respectively. These 3D printed scaffolds possessed multiscale porosity, i.e., 3D interconnected designed macro pores along with intrinsic micro pores. Histomorphology and histomorphometric analysis revealed a significant increase in osteoid like new bone formation, and accelerated mineralization inside SrO and MgO doped 3D printed TCP scaffolds as compared to pure TCP scaffolds. An increase in osteocalcin and type I collagen level was also observed in rat blood serum with SrO and MgO doped TCP scaffolds compared to pure TCP scaffolds. Our results show that these 3D printed SrO and MgO doped TCP scaffolds with multiscale porosity contributed to early healing through accelerated osteogenesis.
Demonstration of wavelength conversion at 40 Gb/s data rate in silicon waveguides (2006)

We report an efficient wavelength conversion via four-wave-mixing in reverse biased silicon-on-isolator p-i-n rib waveguides and demonstrate, for the first time, the conversion of a high-speed optical pseudo-random bit sequence data at 40 Gb/s. Results give a wavelength conversion efficiency of -8.6dB using a 8cm long waveguide with clear open eye on the wavelength converted signal . Conversion efficiency as functions of pump power and bias voltages has also been investigated. We show a slope efficiency close to 2 as predicted by theory.
Vacuum Tubes as High-Frequency Oscillators* (1935)

Vacuum tubes as oscillators and amplifiers at frequencies greater than 100 megacycles (3 m.) are considered in this paper. The type of construction used in a large number of different tubes, and the characteristics of the tubes, are presented. Circuits for operating the tubes also are considered and the theory of operation and the factors limiting ultra-high frequencies are discussed. Principal attention is given to the tubes as oscillators, with brief consideration of the problem of amplification.
Design and Implementation of a Central-Controllable and Secure Multicast System Based on Universal Identifier Network (2018)

With the rapid increase of network users and services, the breadth and depth of Internet have greatly changed. The mismatch between current network requirements and original network architecture design has spurred the evolution or revolution of Internet to remedy this gap. Lots of research projects on future network architecture have been launched, in which Universal Identifier Network (UIN) architecture that is based on the identifier/location separation, access/core separation and control/forwarding separation can provide better mobility, security and reliability. On the other hand, the demand of group communication has increased due to the fine-grained network services and successive booming of new applications such as IoT (Internet of Things). Most of current multicast schemes are based on the open group model with open group membership (multicast only care the multicast group state, not the group member) and open access to send/receive multicast data, which are beneficial to multicast routing for its simplification. However, the open group membership makes the group member management difficult to be realized, and open access may result in lots of security vulnerabilities such as Denial of service (DoS), eavesdropping and masquerading, which make deployment more difficult. Therefore, in this paper we propose a Central-Controllable and Secure Multicast (CCSM) system based on the UIN architecture, and redesign the multicast service procedures including registration, join/leave, multicast routing construction and update with objective to achieve better mobility support, security, scalability and controllable. More specifically, we design a new group management scheme to perform the multicast members join/leave with authentication and a central-controllable multicast routing scheme to provide a secure way to set up multicast entries on routers. The CCSM inherits the characteristics of UIN in terms of mobility and security, and it can provide the centralized multicast routing computation and distributes the multicast routing into forwarders. We compare CCSM with Protocol Independent Multicast-Sparse Mode (PIM-SM), and the results show that CCSM reduces the multicast join delay, and performs better than PIM-SM in term of reconstruction cost under low multicast density.
Fast-response electrooptic deflectors and their use in the control of time parameters of laser pulses in the range 10<sup>−11</sup>–10<sup>−8</sup>sec (1982)

deflectors operated in the pulsed regime for periods ranging from few nanoseconds to tens of nanoseconds. A study was made of reflecting deflectors made of