gebhart/patrepeval huggingface dataset:
Skinning cubic Bézier splines and Catmull-Clark subdivision surfaces (2014)

Smooth space deformation has become a vital tool for the animation and design of 2D and 3D shapes. Linear methods, under the umbrella term of "linear blend skinning", are the de facto standard for 3D animations. Unfortunately such approaches do not trivially extend to deforming vector graphics , such as the cubic Bézier splines prevalent in 2D or subdivision surfaces in 3D. We propose a variational approach to reposition the control points of cubic Bézier splines and Catmull-Clark subdivision surfaces---or any linear subdivision curves or surfaces---to produce curves or surfaces which match a linear blend skinning deformation as closely as possible. Exploiting the linearity of linear blend skinning, we show how this optimization collapses neatly into the repeated multiplication of a matrix per handle. We support C 0 , C 1 , G 1 , and fixed-angle continuity constraints between adjacent Bézier curves in a spline. Complexity scales linearly with respect to the number of input curves and run-time performance is fast enough for real-time editing and animation of high-resolution shapes.
Partitioned signature files: design issues and performance evaluation (1989)

A signature file acts as a filtering mechanism to reduce the amount of text that needs to be searched for a query. Unfortunately, the signature file itself must be exhaustively searched, resulting in degraded performance for a large file size. We propose to use a deterministic algorithm to divide a signature file into partitions, each of which contains signatures with the same “key.” The signature keys in a partition can be extracted and represented as the partition's key. The search can then be confined to the subset of partitions whose keys match the query key. Our main concern here is to study methods for obtaining the keys and their performance in terms of their ability to reduce the search space. Owing to the reduction of search space, partitioning a signature file has a direct benefit in a sequential search (single-processor) environment. In a parallel environment, search can be conducted in parallel effectively by allocating one or more partitions to a processor. Partitioning the signature tile with a deterministic method (as opposed to a random partitioning scheme) provides intraquery parallelism as well as interquery parallelism. In this paper, we outline the criteria for evaluating partitioning schemes. Three algorithms are described and studied. An analytical study of the performance of the algorithms is provided and the results are verified with simulation.
Preconditioning with Lipopolysaccharide or Lipoteichoic Acid Protects against Staphylococcus aureus Mammary Infection in Mice (2017)

<i>Staphylococcus aureus</i> is one of the most causative agents of mastitis and is associated with chronic udder infections. The persistency of the pathogen is believed to be the result of an insufficient triggering of local inflammatory signaling. In this study, the preclinical mastitis model was used, aiming to evaluate if lipopolysaccharide (LPS) or lipoteichoic acid (LTA) preconditioning could aid the host in more effectively clearing or at least limiting a subsequent <i>S. aureus</i> infection. A prototypic Gram-negative virulence factor, i.e., LPS and Gram-positive virulence factor, i.e., LTA were screened whether they were able to boost the local immune compartment. Compared to <i>S. aureus</i>-induced inflammation, both toxins had a remarkable high potency to efficiently induce two novel selected innate immunity biomarkers i.e., lipocalin 2 (LCN2) and chitinase 3-like 1 (CHI3L1). When combining mammary inoculation of LPS or LTA prior to a local <i>S. aureus</i> infection, we were able to modulate the innate immune response, reduce local bacterial loads, and induce either LCN2 or CHI3L1 at 24 h post-infection. Clodronate depletion of mammary macrophages also identified that macrophages contribute only to a limited extend to the LPS/LTA-induced immunomodulation upon <i>S. aureus</i> infection. Based on histological neutrophil influx evaluation, concomitant local cytokine profiles and LCN2/CHI3L1 patterns, the macrophage-independent signaling plays a major role in the LPS- or LTA-pretreated <i>S. aureus</i>-infected mouse mammary gland. Our results highlight the importance of a vigilant microenvironment during the innate immune response of the mammary gland and offer novel insights for new approaches concerning effective immunomodulation against a local bacterial infection.
Vulnerabilities Of Ieee 802.11I Wireless Lan Ccmp Protocol (2007)

IEEE has recently incorporated CCMP protocol to provide robust security to IEEE 802.11 wireless LANs. It is found that CCMP has been designed with a weak nonce construction and transmission mechanism, which leads to the exposure of initial counter value. This weak construction of nonce renders the protocol vulnerable to attacks by intruders. This paper presents how the initial counter can be pre-computed by the intruder. This vulnerability of counter block value leads to pre-computation attack on the counter mode encryption of CCMP. The failure of the counter mode will result in the collapse of the whole security mechanism of 802.11 WLAN.
Practical comprehensive bounds on surreptitious communication over DNS (2013)

DNS queries represent one of the most common forms of network traffic, and likely the least blocked by sites. As such, DNS provides a highly attractive channel for attackers who wish to communicate surreptitiously across a network perimeter, and indeed a variety of tunneling toolkits exist [7, 10, 13–15]. We develop a novel measurement procedure that fundamentally limits the amount of information that a domain can receive surreptitiously through DNS queries to an upper bound specified by a site’s security policy, with the exact setting representing a tradeoff between the scope of potential leakage versus the quantity of possible detections that a site’s analysts must investigate. Rooted in lossless compression, our measurement procedure is free from false negatives. For example, we address conventional tunnels that embed the payload in the query names, tunnels that repeatedly query a fixed alphabet of domain names or varying query types, tunnels that embed information in query timing, and communication that employs combinations of these. In an analysis of 230 billion lookups from real production networks, our procedure detected 59 confirmed tunnels. For the enterprise datasets with lookups by individual clients, detecting surreptitious communication that exceeds 4 kB/day imposes an average analyst burden of 1–2 investigations/week. 1
Controlled Release of Isoproturon, Imidacloprid, and Cyromazine from Alginate−Bentonite-Activated Carbon Formulations (2006)

Different alginate-based systems of isoproturon, imidacloprid, and cyromazine have been investigated in order to obtain controlled release (CR) properties. The basic formulation [sodium alginate (1.50%), pesticide (0.30%), and water] was modified using different amounts of bentonite and activated carbon. The higher values of encapsulation efficiency corresponded to those formulations prepared with higher percentages of activated carbon, showing higher encapsulation efficiency values for isoproturon and imidacloprid than for cyromazine, which has a higher water solubility. The kinetic experiments of imidacloprid/isoproturon release in water have shown us that the release rate is higher in imidacloprid systems than in those prepared with isoproturon. Moreover, it can be deduced that the use of bentonite and/or activated carbon sorbents reduces the release rate of the isoproturon and imidacloprid in comparison with the technical product and with alginate formulation without modifying agents. The highest decrease in release rate corresponds to the formulations prepared with the highest percentage of activated carbon. The water uptake, permeability, and time taken for 50% of the active ingredient to be released into water, T50, were calculated to compare the formulations. On the basis of a parameter of an empirical equation used to fit the pesticide release data, the release of isoproturon and imidacloprid from the various formulations into water is controlled by a diffusion mechanism. The sorption capacity of the sorbents and the permeability of the formulations were the most important factors modulating pesticide release. Finally, a linear correlation of the T50 values and the content of activated carbon in formulations were obtained.
A Versatile Memristor Model With Nonlinear Dopant Kinetics (2011)

The need for reliable models that take into account the nonlinear kinetics of dopants is nowadays of paramount importance, particularly with the physical dimensions of electron devices shrinking to the deep nanoscale range and the development of emerging nanoionic systems such as the memristor. In this paper, we present a novel nonlinear dopant drift model that resolves the boundary issues existing in previously reported models that can be easily adjusted to match the dynamics of distinct memristive elements. With the aid of this model, we examine switching mechanisms, current-voltage characteristics, and the collective ion transport in two terminal memristive devices, providing new insights on memristive behavior.
Determination of protein-ligand equilibriums by difference spectroscopy. Hemerythrin-ligand thermodynamic studies (1981)

A difference spectrophotometric method for the rapid determination of equilibrium constants for protein--ligand interactions has been developed. The method requires no knowledge of the extinction coefficient of either reactants or products. Furthermore the method allows rapid determination of the temperature dependence of a reaction and thus leads to rapid determination of thermodynamic parameters. The method has been tested by following the interactions of ligands with hemerythrin, the nonheme iron, oxygen storage protein isolated from Phasocolopsis gouldii. The reactions were studied at various temperatures and ionic strengths, and standard thermodynamic parameters were determined. The standard thermodynamic parameters for the conversion of metaquohemerythrin to methydroxyhemerythrin were found to be delta H degrees = 5.8 +/- 1.3 kcal mol-1 and delta S degrees = -11.5 +/- 1.5 cal mol-1 deg-1. For the reaction of metaquohemerythrin with thiocyanate ion to produce metthiocyanatohemerythrin delta H degrees = --13.0 +/- 1.6 kcal mol-1 and delta S degrees - --25.3 +/- 5.5 cal mol-1 deg-1. For the reaction of thiocyanate ion with methydroxy-hemerythrin delta H degrees = --6.6 +/- 0.8 kcal mol-1 and delta S degrees = --38.3 +/- 4.0 cal mol-1 deg-1. Perchlorate ion decreases the affinity of metaquohemerhythrin for thiocyanate ion. This is reflected in both the entropy and enthalpy being more unfavorable for the reaction in the presence of perchlorate ion.
The pathogenic mechanisms of Shiga toxin and the Shiga‐like toxins (1991)

Summary It is now well documented that some enteric bacteria which cause diarrhoeal and/or dysenteric disease produce, at high levels, one or more of a family of protein toxins referred to as Shiga toxin and Shiga‐like toxins (SLTs; alternatively called verocytotoxins or VTs). Within the past few years, there have been considerable advancements made in our understanding of the biochemistry and molecular biology of Shiga toxin and SLTs. However, the precise role of the toxins in mediating colonic disease, as well as their contribution to the development of extra‐intestinal sequelae (e.g. the haemolytic uraemic syndrome and neurological disorders), remain less clear. In this MicroReview , we will briefly summarize recent progress in Shiga toxin‐ and SLT‐related research and present evidence supporting the concept that these toxins contribute to pathogenesis by directly damaging vascular endothelial cells, thereby disrupting the homeostatic properties of these cells. We will also discuss data which suggest that toxin‐mediated damage in the kidney may not be limited to glomerular endothelial cells but may include tubular epithelial cells. Thus, the role of the toxins in renal disease may not be limited to the glomeruli, as was initially hypothesized when the association of infection with toxin‐producing strains and the development of acute renal failure was established.
Broad-band networks for LAN and radio applications (2003)

Two versions of broadband networks are proposed. These versions, multichannel and sequential multichannel, both use a CSMA/CA protocol for medium-access control, which makes them suitable for LANs as well as for radio applications. The system description highlights the main differences between the two versions. Throughput calculations for the multichannel system using the two cases of nonpersistent and slotted nonpersistent CSMA/CA protocols show that in each case a higher throughput can be achieved with better reliability compared to single-channel operation. A sequential multichannel system is also proposed and its mode of operation and limitations are discussed. A comparison of the desirable features of the two proposed versions with other possible systems is given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Translocation of Manganese in Subterranean Clover ( <i>Trifolium subterraneum</i> L. Cv. Seaton Park). II. Effect of Leaf Senescence and of Restricting Supply of Manganese to Part of a Split Root System (1984)

Split root systems were used to examine the hypothesis that manganese is not mobile in the phloem of subterranean clover plants during vegetative growth. The effect of senescence on manganese mobility was also examined by shading mature leaves. Plants given a luxury supply of radioactive manganese to one half of a split root system failed to translocate any more than a trace of manganese to the other half. Shading and subsequent senescence of a large number of leaves did not cause movement of manganese from them. Omitting an external supply of manganese depressed growth of roots but produced no visual abnormalities even though Mn concentrations decreased to 5 µg/g dry matter of root.
Mutational analysis of repression and activation of the tyrP gene in Escherichia coli (1991)

In a previous report it had been suggested that the tyrP gene of Escherichia coli may be expressed from two separate promoters. We have endeavored to confirm this suggestion by primer extension studies and the separate subcloning of each of these promoters. In these studies, we found a single promoter whose expression was repressed by TyrR protein in the presence of tyrosine and activated by TyrR protein in the presence of phenylalanine. Two adjacent TYR R boxes, with the downstream one overlapping the tyrP promoter, are the likely targets for the action of TyrR protein. Mutational analysis showed that both TYR R boxes were required for tyrosine-mediated repression but that only the upstream box was required for phenylalanine-mediated activation. In vitro DNase protection studies established that whereas in the absence of tyrosine TyrR protein protected the region of DNA represented by the upstream box, at low TyrR protein concentrations both tyrosine and ATP were required to protect the region of DNA involving the downstream box and overlapping the RNA polymerase binding site.
Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer (2008)

The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics.
Über enantiomere Lokalanästhetica vom Typ des N‐Aminoacyl‐2,6‐dimethylanilins (1968)

Abstract Enantiomere N‐Aminoacyl‐2,6‐dimethylaniline hemmen die Geschwindigkeit der Erregungsleitung im Ventrikelstreifen des Froschherzens in unterschiedlichem Ausmaß. Dieser Befund wird auf eine Wechselwirkung der optisch aktiven Lokalanästhetica‐Moleküle mit asymmetrischen Strukturen der Zellmembran zurückgeführt.
Minimally privacy-violative human location sensor by ultrasonic radar embedded on ceiling (2006)

A system observing human daily activities that may violate privacy is unacceptable in our society. This paper proposes a minimally privacy-violative system for locating a person using ultrasonic radar embedded in the ceiling of a room. One of the presumable applications is a system for preventing aged people suffering from Alzheimer's disease from accidents. The proposed system can determine the 3D position of a person's head by assuming that the human head is an object that will move at a relatively high vertical position in a living area. The system does not input unnecessarily rich information such as images using a camera so that it can reduce the possibility for violating privacy. The authors constructed an experimental system that consists of 18 ultrasonic transmitters and 32 receivers which are embedded in the ceiling of a room. Experimental results confirmed the feasibility of the proposed system.
Reduction of DABS-L-methionine-dl-sulfoxide by protein methionine sulfoxide reductase from polymorphonuclear leukocytes: stereospecificity towards the l-sulfoxide. (1995)

A new synthetic substrate for protein methionine sulfoxide reductase is proposed. We show that extracts from human polymorphonuclear leukocytes can reduce 4-dimethylaminoazobenzene-4'-sulfonyl-L-methionine-dl-sulfoxide [DABS-L-Met-dl-(O)] to the corresponding methionine derivative, in the presence of dithiothreitol or dithioerythritol. The product of the reaction (DABS-Met) was separated by reversed-phase HPLC and detected by reading the absorbance at 436 nm. Due to the chirality of the sulfur atom in the sulfoxide, two diastereomers of Met(O) exist, namely Met-l-sulfoxide and Met-d-sulfoxide. After separation of the two forms and preparation of the DABS-derivatives, we observed a preferential reduction of the l-sulfoxide by polymorphonuclear leukocytes extracts. We discuss the possibility that the observed stereospecificity might have physiological relevance in the field of the oxidative modifications of proteins.
A simple method to obtain a swollen PVA gel crosslinked by hydrogen bonds (2009)

Abstract A simple method to obtain a physically crosslinked poly(vinyl alcohol) (PVA) hydrogel is reported. In this technique, the PVA solution in pure water was simply cast at room temperature without using any additional chemical. The gelation proceeded during the dehydration after casting the PVA solution into a mold. After the completion of gelation, the swelling ratio of the gel in its equilibrium was measured whenever the solvent water was repeatedly exchanged. The weight gradually decreased due to the elution of non‐crosslinked polymers into the solvent, and became constant after sufficient water exchange. The measurements using a Fourier Transform infrared spectroscopy and an X‐ray diffraction suggested that the crosslinks due to hydrogen bonds and microcrystals were formed during the dehydration process of the PVA solution. We concluded that the sample obtained by the present method is a physically crosslinked polymer network, insoluble in water, i.e., a swollen gel in water. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Characterization and analysis of scFv-IgG bispecific antibody size variants (2018)

Bispecific antibodies are an emergent class of biologics that is of increasing interest for therapeutic applications. In one bispecific antibody format, single-chain variable fragments (scFv) are linked to or inserted in different locations of an intact immunoglobulin G (IgG) molecule to confer dual epitope binding. To improve biochemical stability, cysteine residues are often engineered on the heavy- and light-chain regions of the scFv to form an intrachain disulfide bond. Although this disulfide bond often improves stability, it can also introduce unexpected challenges to manufacturing or development. We report size variants that were observed for an appended scFv-IgG bispecific antibody. Structural characterization studies showed that the size variants resulted from the engineered disulfide bond on the scFv, whereby the engineered disulfide was found to be either open or unable to form an intrachain disulfide bond due to cysteinylation or glutathionylation of the cysteines. Furthermore, the scFv engineered cysteines also formed intermolecular disulfide bonds, leading to the formation of highly stable dimers and aggregates. Because both the monomer variants and dimers showed lower bioactivity, they were considered to be product-related impurities that must be monitored and controlled. To this end, we developed and optimized a robust, precise, and accurate high-resolution size-exclusion chromatographic method, using a statistical design-of-experiments methodology.
Performance evaluation of simple linear iterative clustering algorithm on medical image processing (2014)

Simple Linear Iterative Clustering (SLIC) algorithm is increasingly applied to different kinds of image processing because of its excellent perceptually meaningful characteristics. In order to better meet the needs of medical image processing and provide technical reference for SLIC on the application of medical image segmentation, two indicators of boundary accuracy and superpixel uniformity are introduced with other indicators to systematically analyze the performance of SLIC algorithm, compared with Normalized cuts and Turbopixels algorithm. The extensive experimental results show that SLIC is faster and less sensitive to the image type and the setting superpixel number than other similar algorithms such as Turbopixels and Normalized cuts algorithms. And it also has a great benefit to the boundary recall, the robustness of fuzzy boundary, the setting superpixel size and the segmentation performance on medical image segmentation.
Robust rank aggregation for gene list integration and meta-analysis (2012)

All the methods are implemented as a GNU R package RobustRankAggreg, freely available at the Comprehensive R Archive Network http://cran.r-project.org/.
Escherichia Coli in Domestic Animals and Poultry (1965)

Escherichia coli in domestic animals and poultry , Escherichia coli in domestic animals and poultry , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Igreja católica e ecumenismo/inculturação: da revisão conceitual ao impasse com o advento das estratégias de marketing (2012)

Este artigo apresenta a evolução do pensamento e da prática de ecume­nismo e inculturação adotados pela Igreja Católica até sua história mais recente no Brasil, quando o contexto pluralista, a disputa religiosa (sobretudo com as Igrejas neopentecostais) pela conquista de fiéis, notadamente por meio de estratégias de marketing, colocam em suspensão - se não, em crise - o projeto ecumênico oficialmente assumido por essa instituição. Nesse sentido, o esforço de diálogo, de aproximação e cooperação recíproca entre católicos e cristãos de outras denominações está em flagrante conflito com a luta pela hegemonia religiosa na sociedade brasileira.