gebhart/patrepeval huggingface dataset:
Identification of a Crucial Residue Required for Staphylococcus aureus LukAB Cytotoxicity and Receptor Recognition (2013)

ABSTRACT The bicomponent leukotoxins produced by Staphylococcus aureus kill host immune cells through osmotic lysis by forming β-barrel pores in the host plasma membrane. The current model for bicomponent pore formation proposes that octameric pores, comprised of two separate secreted polypeptides (S and F subunits), are assembled from water-soluble monomers in the extracellular milieu and multimerize on target cell membranes. However, it has yet to be determined if all staphylococcal bicomponent leukotoxin family members exhibit these properties. In this study, we report that leukocidin A/B (LukAB), the most divergent member of the leukotoxin family, exists as a heterodimer in solution rather than two separate monomeric subunits. Notably, this property was found to be associated with enhanced toxin activity. LukAB also differs from the other bicomponent leukotoxins in that the S subunit (LukA) contains 33- and 10-amino-acid extensions at the N and C termini, respectively. Truncation mutagenesis revealed that deletion of the N terminus resulted in a modest increase in LukAB cytotoxicity, whereas the deletion of the C terminus rendered the toxin inactive. Within the C terminus of LukA, we identified a glutamic acid at position 323 that is critical for LukAB cytotoxicity. Furthermore, we discovered that this residue is conserved and required for the interaction between LukAB and its cellular target CD11b. Altogether, these findings provide an in-depth analysis of how LukAB targets neutrophils and identify novel targets suitable for the rational design of anti-LukAB inhibitors.
SAR Studies of Sesquiterpene Lactones as <i>Orobanche cumana</i> Seed Germination Stimulants (2002)

Studies of the structure-activity relationship (SAR) directed to evaluate the effect of several sesquiterpene lactones (SL) as germination stimulants of three Orobanche spp. (O. cumana, O. crenata, and O. ramosa) have been achieved. Results are compared with those obtained in the same bioassay with an internal standard, the synthetic analogue of strigol GR-24. A high specificity in the germination activity of SL on the sunflower parasite O. cumana has been observed, and a relationship between such activity and the high sunflower SL content is postulated. Molecular properties of the natural and synthetic germination stimulants (GR-24, GR-7, and Nijmegen-1) and SL have been studied using MMX and PM3 calculations. Consequently, comparative studies among all of them and their activities have been made. SL tested present similarities in molecular properties such as the volume of the molecule and the spatial disposition of the carbon backbone to the natural germination stimulant orobanchol. These properties could be related to their biological activity.
Growth of Diamond Thin Films by dc Plasma Chemical Vapor Deposition and Characteristics of the Plasma (1990)

Diamond thin films have been formed by dc plasma chemical vapor deposition from a gaseous mixture of methane and hydrogen (gas ratio (CH 4 /H 2 ); 2/100, total gas pressure; 2.66×10 4 Pa) with a growth rate of ∼20 µm/h. During the course of diamond growth, characteristics of the plasma were measured by the Langmuir single probe method and also by emission spectrometry. From the characterization of the plasma, it was found that the degree of ionization was rather low (∼10 -7 ), and the statistical temperature of hydrogen gas was ∼5×10 3 K. By a thermodynamic investigation at the gas temperature around 5×10 3 K, it was revealed that the source gases (H 2 and CH 4 ) of over 99% are decomposed to neutral atomic hydrogen and atomic carbon.
United States v. Parke Davis (1960)

The leadership of the US's most complex academic health centers (AHCs)/medical centers requires individuals who possess a high level of clinical, organizational, managerial, and interpersonal skills. This paper first outlines the major attributes desired in a dean/vice president of health affairs before then summarizing the educational opportunities now generally available to train for such leadership and management roles. For the most part, the masters in health administration (MHA), the traditional MBA, and the numerous alternatives primarily available at universities are considered far too general and too lacking in emotional intelligence tutoring to be particularly relevant for those who aspire to these most senior leadership positions. More appropriate educational options for these roles are discussed: (a) the in-house leadership and management programs now underway at some AHCs for those selected early on in their career for future executive-type roles as well as for those who are appointed later on to a chair, directorship or similar position; and (b) a more controversial approach of potentially establishing at one or a few universities, a mid-career, professional program (a maximum of 12 months and therefore, being completed in less time than an MBA) leading to a masters degree in academic health center administration (MHCA) for those who aspire to fill a senior AHC leadership position. The proposed curriculum as outlined herein might be along the lines of some carefully designed masters level on-line, self-teaching modules for the more technical subjects, yet vigorously emphasizing integrate-type courses focused on enhancing personal and professional team building and leadership skills.
Sudden infant death syndrome: hypothesis of causation. (1975)

The airway of the young infant is anatomically vulnerable at the oropharyngeal level between the soft palate and the base of the skull. Airway occlusion at this level might occur during the muscle relaxation which occurs during REM sleep, facilitated by a hypermobile mandible, by the hypotonia of infection, perhaps by an enlarged tongue with a strong backwards sucking action which might be the result of the artificial feeding of the infant. It is possible that "cot deaths" (SIDS) may be precipitated by such oropharyngeal airway occlusion, cardiac arrest following variable periods of partial or complete oxygen deprivation.
SEEPAGE FLOW INTO FLORIDA LAKES<sup>1</sup> (1980)

ABSTRACT: Direct measurements indicate that subsurface seepage in the littoral zone contributed 17.5 and 2.0 percent of the total hydraulic inputs, respectively, to Lakes Conway and Apopka, Florida. Two variations of seepage measuring devices were evaluated and gave relative standard deviations of 7 and 24 percent. Measurement inaccuracies were minimized by using large diameter (0.9 cm ID) plastic tubing. For a given transect perpendicular to shore, flow patterns were reproducible over time. Seepage flows ranged from 0 to 112 1/m 2 ‐day and most were between 4 and 30 1/m 2 ‐day. The detection limit was about 0.2 1/m 2 ‐day for a one‐hour collection period. Seepage occured primarily within 30 m of shore and generally decreased exponentially with distance from shore. The shape of the bottom profile influenced flow patterns; lake bottoms with steeper slopes had higher flows that were compressed within a narrower zone. After a short‐term rain event at Lake Conway, seepage flows increased rapidly to 2.4 times the prerain flow for 1 h and decreased to near background within about 6 h.
Growth factor requirements of childhood acute T-lymphoblastic leukemia: correlation between presence of chromosomal abnormalities and ability to grow permanently in vitro (1991)

Cells from 10 cases of childhood acute T-lymphoblastic leukemia (T-ALL) were cultured in the presence of recombinant human interleukins (rhIL) or colony-stimulating factors (CSF) to analyze their growth factor requirements and differentiative potential. Although cells from most leukemic samples displayed a short-term proliferative response to several hematopoietic growth factors, only the ones featuring chromosomal translocations could be established as permanent cell lines. Two cell lines could be initiated only in the presence of IL-3 (TALL-103 and TALL-106), one in granulocyte-macrophage CSF (GM-CSF) (TALL-101), and one in IL-2 (TALL-104); only one cell line (TALL-105) was originated in the absence of growth factors. The TALL-101 and TALL-103 cell lines, derived from very immature T-ALL cases, underwent growth factor-dependent phenotypic conversion (lymphoid to myeloid). However, the T-cell receptor rearrangement and karyotype of the original leukemic clones were retained. In contrast, the TALL-104, -105, and -106 cell lines which originated from more mature T-ALL cases, maintained a T-lymphoblastic phenotype regardless of the growth factors in which they were expanded. These data demonstrate in vitro the aggressive nature of T-ALL cases bearing chromosomal abnormalities, and indicate that the lineage commitment of the malignant clone depends on its stage of maturation in T-cell ontogeny.
An Efficient Interval Type-2 Fuzzy CMAC for Chaos Time-Series Prediction and Synchronization (2013)

This paper aims to propose a more efficient control algorithm for chaos time-series prediction and synchronization. A novel type-2 fuzzy cerebellar model articulation controller (T2FCMAC) is proposed. In some special cases, this T2FCMAC can be reduced to an interval type-2 fuzzy neural network, a fuzzy neural network, and a fuzzy cerebellar model articulation controller (CMAC). So, this T2FCMAC is a more generalized network with better learning ability, thus, it is used for the chaos time-series prediction and synchronization. Moreover, this T2FCMAC realizes the un-normalized interval type-2 fuzzy logic system based on the structure of the CMAC. It can provide better capabilities for handling uncertainty and more design degree of freedom than traditional type-1 fuzzy CMAC. Unlike most of the interval type-2 fuzzy system, the type-reduction of T2FCMAC is bypassed due to the property of un-normalized interval type-2 fuzzy logic system. This causes T2FCMAC to have lower computational complexity and is more practical. For chaos time-series prediction and synchronization applications, the training architectures with corresponding convergence analyses and optimal learning rates based on Lyapunov stability approach are introduced. Finally, two illustrated examples are presented to demonstrate the performance of the proposed T2FCMAC.
A phospholipid complex to improve the oral bioavailability of flavonoids (2014)

The oral absorption of isorhamnetin, kaempferol, and quercetin was significantly improved in TFH-PC, mainly due to increased solubility and dissolution rate. This phospholipid complex shows potential for oral delivery of the flavonoids in TFH.
Mesenchymal stem cells promote leukaemic cells aberrant phenotype from B-cell acute lymphoblastic leukaemia (2013)

Lymphoid cell maintenance, at early stages of differentiation, was significantly promoted by BM-MSC in normal and leukaemic cells. Co-cultures also modulated the expression of antigens associated with the B-ALL asynchronous phenotype as CD10 co-expressed with CD19 and CD20. To our knowledge, this is the first time that CD10, CD19 and CD20 leukaemic antigens have been reported as being regulated by BM-MSC.
Personalised evaluation of self-hypnosis as a treatment of chronic pain: a repertory grid analysis (1988)

Self-hypnosis was taught to 5 highly hypnotisable patients referred to Auckland Hospital Pain Clinic. Evaluation included the Illness Self-Concept Repertory Grid (ISCRG) and follow-up was at 1 and 6 months post treatment. Consensus grids indicated the subjects initially identified with physical illness but this association decreased over the course of the study. There appeared, therefore, to be a shift in self-concept away from physical illness, in association with the learning and practice of self-hypnosis. This change was especially evident in the grids of those subjects who experienced the most pain relief. An association between pain reduction and self-concepts is thus noted. This study does not identify whether self-concepts merely reflect therapeutic change or whether strong self-identification with physical illness indicates a poor prognosis for pain relief. This is a question which deserves further study.
Determination of the hemoglobin F program in human progenitor-derived erythroid cells. (1985)

The absolute adult and fetal hemoglobin (HbF) contents of the erythroid cells derived from the differentiation of normal human and simian erythroid progenitors and of the peripheral blood erythroid burst-forming units (BFU-E) of patients with nondeletion hemoglobinopathies have been measured with a sensitive radioligand immunoassay. The HbF content varied between 0.13 and 2.96 pg/cell, representing between 0.7% and 19.6% of the total hemoglobin with a mean value of 7.0%. The absolute content of HbF was indistinguishable in the well-hemoglobinized progeny of marrow erythroid colony-forming units, marrow or blood BFU-E, or of mixed colony-forming units. The term HbF program refers to this inherent capacity to produce fetal hemoglobin (HbF) in the erythroid cells derived from these progenitors in vitro. The HbF content of marrow erythroblasts as determined by the same radioligand immunoassay was similar to that found in the peripheral blood, suggesting that the switch off of gamma-chain production occurs after the erythroid colony-forming unit stage of maturation. Increasing concentrations of a crude erythropoietin-containing preparation induced higher numbers of erythroid colonies, which were larger in size, but the HbF program was unaffected. In contrast to the hemoglobin accumulation in human progenitor-derived colonies, simian progenitor-derived colonies produced considerably more HbF, and the amount of HbF was strongly influenced by progenitor maturity. Assays of the HbF content of erythroblasts derived from culture of the peripheral blood BFU-E of patients with nondeletion hemoglobinopathies and their parents showed that the HbF program in the progenitors of such patients is highly variable. Some produce only a slight excess of HbF in progenitor-derived erythroblasts, whereas others have extraordinarily high HbF programs. The molecular basis of this variability is presently unknown.
Electrically Induced Gait Changes Post Stroke, Using an FNS System with Intramuscular Electrodes and Multiple Channels (1993)

This study investigated the feasibility and benefit of using a multichannel functional neuromuscular stimulation (FNS) system with intramuscular electrodes for stroke rehabilitation. The subject was 46 years old and four years post-left CVA, with right hemiparesis resulting in multiple gait deficits that were unchanged for two years prior to entry into the study. Ten muscles were implanted with intramuscular electrodes. The stimulator controlled each channel separately, providing adjustable stimulation patterns for FNS exercise and gait training. Outcome measures were gait swing phase kinematics: knee flexion at toe-off ; peak swing knee flexion; and knee extension prior to heelstrike. Tests were conducted during voluntary walking (no FNS), before and after nine months of FNS treatment. Following treatment, the gait pattern was significantly improved for knee flexion at toe-off, peak swing knee flexion, and knee extension prior to heelstrike. Former right swing phase compensatory movements were resolved. With the intramuscular electrodes, it was possible to stimulate specific muscles, obtain consistent muscle response from day to day, and use sufficient stimulus intensity within comfort to obtain a useful therapeutic effect. The microprocessor-based stimulator made possible a well-coordinated movement pattern. These results support the merit of further study of this FNS system for exercise and gait training treatment post-stroke.
Electromagnetic absorption in the human head and neck for mobile telephones at 835 and 1900 MHz (1996)

The authors have used the finite-difference time-domain method and a new millimeter-resolution anatomically based model of the human to study electromagnetic energy coupled to the head due to mobile telephones at 835 and 1900 MHz. Assuming reduced dimensions characteristic of today's mobile telephones, the authors have obtained SAR distributions for two different lengths of monopole antennas of lengths /spl lambda//4 and 3/spl lambda//8 for a model of the adult male and reduced-scale models of 10- and 5-year-old children and find that peak one-voxel and 1-g SARs are larger for the smaller models of children, particularly at 835 MHz. Also, a larger in-depth penetration of absorbed energy for these smaller models is obtained. The authors have also studied the effect of using the widely disparate tissue properties reported in the literature and of using homogeneous instead of the anatomically realistic heterogeneous models on the SAR distributions. Homogeneous models are shown to grossly overestimate both the peak 1-voxel and 1-g SARs. Last, the authors show that it is possible to use truncated one-half or one-third models of the human head with negligible errors in the calculated SAR distributions. This simplification will allow considerable savings in computer memory and computation times.
Acetylfurans as Bio-Isosteres for 3-Methylisoxazole. The Effect of Acetylfuran Positional Isomers on Antirhinoviral Activity (1996)

A panel of four isomeric acetylfuran analogues of disoxaril were prepared. Using a 96-well tissue culture inhibitory dose assay (TCID), these acetylfuran isomers were screened against 15 rhinovirus serotypes. Comparison of the results obtained suggested that antiviral activity was related to hydrogen bond participation by the carbonyl oxygen within the viral pocket. Modelling acetylfuran conformations using an X-ray crystal structure template of 1 in HRV-14 demonstrates that three of the four isomers can adopt the desired conformation for this hydrogen bonding, and the fourth isomer 15 is prohibited by steric constraints from achieving the necessary conformation. These observations are consistent with the hypothesis that broad-spectrum antirhinoviral activity may require a hydrogen bond acceptor at that region of the inhibitor.
A novel numerical technique for dielectric measurement of generally lossy dielectrics (1992)

A method for determining the dielectric properties of infinite half-space of generally lossy dielectric materials is described. This method utilizes the measurement of the admittance of a rectangular waveguide radiating into such dielectrics. It is shown that the real part of the admittance is relatively insensitive to the variations of the imaginary part of the dielectric constant. A numerical procedure is initiated which provides a simple and fast-converging approach for calculating the dielectric properties. This numerical procedure lends itself to implementation by personal computers. The theoretical formulation for the expression of the admittance of an open-ended waveguide and the numerical procedure are discussed in detail. Results of several measurements of freespace and lossy dielectric samples (rubber with carbon black) to verify the theory and the numerical scheme are given. The results give good agreement with other measurement schemes. Comments on the accuracy of the results are also provided.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Inversion of gravity data with an exponential density contrast model (1992)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1992Inversion of gravity data with an exponential density contrast modelAuthors: Jianghai XiaDonald R. SprowlJianghai XiaKansas Geological Survey and Donald R. SprowlUniv. of Kansashttps://doi.org/10.1190/1.1822137 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1822137FiguresReferencesRelatedDetailsCited byGeothermal field interpretation in south‐central Kansas for parts of the Nemaha Anticline and flanking Cherokee and Sedgwick basins6 November 2007 | Basin Research, Vol. 5, No. 4 SEG Technical Program Expanded Abstracts 1992 ISSN (print):1052-3812 ISSN (online):1949-4645 Copyright: 1992 Pages: 1410 publication data© 1992 Copyright © 1992 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Jianghai Xia and Donald R. Sprowl, (1992), "Inversion of gravity data with an exponential density contrast model," SEG Technical Program Expanded Abstracts : 525-528. https://doi.org/10.1190/1.1822137 Plain-Language Summary PDF DownloadLoading ...
Strength enhancement of concrete containing MSW incinerator ash (1995)

In previous work pretreatment of fresh municipal solid waste (MSW) incinerator ash with a novel type of additive, which was not identified chemically in that paper, was shown to markedly increase the compressive strength of portland cement concrete using the MSW ash as fine aggregate. A recent study has shown that, at lower levels of additive, aged MSW ash does not demonstrate the same enhancement. This presentation will provide additional information concerning the previous study, give the results of the current one and discuss the implications of both.
You're Only as Old as Your Arteries: Translational Strategies for Preserving Vascular Endothelial Function with Aging (2014)

Endothelial dysfunction develops with age and increases the risk of age-associated vascular disorders. Nitric oxide insufficiency, oxidative stress, and chronic low-grade inflammation, induced by upregulation of adverse cellular signaling processes and imbalances in stress resistance pathways, mediate endothelial dysfunction with aging. Healthy lifestyle behaviors preserve endothelial function with aging by inhibiting these mechanisms, and novel nutraceutical compounds that favorably modulate these pathways hold promise as a complementary approach for preserving endothelial health.
Room for improvement: unmet needs in postoperative pain management (2012)

Postoperative pain treatment is an important healthcare issue. However, the management of pain in patients after surgery remains insufficient. In the present review, several key areas important for postoperative pain management are discussed. New findings about efficacy and side effects of nonopioid analgesics, such as paracetamol, NSAIDs and COX-2 inhibitors, are presented and discussed in light of acute, short-term application in the perioperative period. Second, new findings about postoperative pain management in patients with preoperative pain and chronic opioid consumption are reported. Third, feasibility of the transversus abdominal plane block as a new and promising regional anesthesia technique is discussed. Finally, potential predictors, mechanisms and preventive treatment strategies of persistent chronic pain after surgery are presented.