gebhart/patrepeval huggingface dataset:
DNA-dependent RNA polymerases I and II from kidney. Effect of polyamines on the in vitro transcription of DNA and chromatin (1975)

DNA-dependent RNA polymerases I and II were purified from pig kidney nuclei by chromatography on DEAE-Sephadex and phosphocellulose. When nonlimiting amounts of double-stranded DNA were used as the template, the in vitro transcription was markedly stimulated by spermidine and spermine. Maximal stimulation of RNA polymerase I occurred at 2-5 mM spermidine and 0.5-2 mM spermine, whereas optimal polyamine concentrations for RNA polymerase II were 5-10 and 1-5 mM for spermidine and spermine, respectively. DNA transcription by polymerase II was stimulated to a greater extent than that of polymerase I. Higher spermine (5-10 mM) concentrations were strong inhibitors of both polymerases under these conditions. The apparent Km of RNA polymerases I and II for UTP was unchanged at optimal polyamine concentration; under the same conditions the maximal reaction velocity was increased two- to three-fold and was essentially due to an increase in the rate of chain elongation. Thus, in a typical experiment the average chain length as determined by the UMP/uridine ratio increased from 570 to 1330 and the chain elongation rate increased from 0.64 to 1.44 nucleotides times sec-1 in the presence of spermine. When limiting quantities of native DNA were employed as the template, both RNA polymerases I and II were inhibited by 1-2 mM spermine. Kidney chromatin could be transcribed by homologous RNA polymerases with an efficiency ranging from 2 to 10% of that with native DNA. When chromatin was used in nonlimiting amounts instead of DNA, RNA polymerase II activity was again stimulated about two-fold at 2 mM spermine. Under these conditions, RNA polymerase I activity was inhibited by spermine. The inhibition of RNA synthesis in vitro at limiting quantities of templates (DNA or chromatin) could be overcome by preincubation of the enzyme with templates before polyamines were added. This inhibition thus appears to be due to a block in the initiation of RNA chains. Similar inhibition of transcription by RNA polymerase II was also observed with limiting quantities of chromatin as the template.
Semantic Matching in Search (2014)

Relevance is the most important factor to assure users’ satisfaction in search and the success of a search engine heavily depends on its performance on relevance. It has been observed that most of the dissatisfaction cases in relevance are due to term mismatch between queries and documents (e.g., query “ny times” does not match well with a document only containing “New York Times”), because term matching, i.e., the bag-of-words approach, still functions as the main mechanism of modern search engines. It is not exaggerated to say, therefore, that mismatch between query and document poses the most critical challenge in search. Ideally, one would like to see query and document match with each other, if they are topically relevant. Recently, researchers have expended significant effort to address the problem. The major approach is to conduct semantic matching, i.e., to perform more query and document understanding to represent the meanings of them, and perform better matching between the enriched query and document representations. With the availability of large amounts of log data and advanced machine learning techniques, this becomes more feasible and significant progress has been made recently. This survey gives a systematic and detailed introduction to newly developed machine learning technologies for query document matching (semantic matching) in search, particularly web search. It focuses on the fundamental problems, as well as the state-of-the-art solutions of query document matching on form aspect, phrase aspect, word sense aspect, topic aspect, and structure aspect. The ideas and solutions explained may motivate industrial practitioners to turn the research results into products. The methods introduced and the discussions made may also stimulate academic researchers to find new research directions and approaches. Matching between query and document is not limited to search and similar problems can be found in question answering, online advertising, cross-language information retrieval, machine translation, recommender systems, link prediction, image annotation, drug design, and other applications, as the general task of matching between objects from two different spaces. The technologies introduced can be generalized into more general machine learning techniques, which is referred to as learning to match in this survey.
Fully Automatic Analysis of Engagement and Its Relationship to Personality in Human-Robot Interactions (2016)

Engagement is crucial to designing intelligent systems that can adapt to the characteristics of their users. This paper focuses on the automatic analysis and classification of engagement based on humans' and robot's personality profiles in a triadic human-human-robot interaction setting. More explicitly, we present a study that involves two participants interacting with a humanoid robot, and investigate how participants' personalities can be used together with the robot's personality to predict the engagement state of each participant. The fully automatic system is first trained to predict the Big Five personality traits of each participant by extracting individual and interpersonal features from their nonverbal behavioural cues. Second, the output of the personality prediction system is used as an input to the engagement classification system. Third, we focus on the concept of “group engagement”, which we define as the collective engagement of the participants with the robot, and analyze the impact of similar and dissimilar personalities on the engagement classification. Our experimental results show that: 1) using the automatically predicted personality labels for engagement classification yields an F-measure on par with using the manually annotated personality labels, demonstrating the effectiveness of the automatic personality prediction module proposed; 2) using the individual and interpersonal features without utilizing personality information is not sufficient for engagement classification, instead incorporating the participants and robots personalities with individual/interpersonal features increases engagement classification performance; and 3) the best classification performance is achieved when the participants and the robot are extroverted, while the worst results are obtained when all are introverted.
Modification of phenol–formaldehyde resol resins by lignin, starch, and urea (2003)

Abstract Lignin‐based chemicals, starch, and urea were used as modifiers for phenol–formaldehyde resol resins. The effects of the addition stage of the modifiers used in the synthesis of the resins and the type of modification reagent on the structures of the resins and their molar masses and reactivities were investigated. The modifications with corn starch and lignin promoted condensation; this was verified by increased molar masses and high ratios of methylene bridges to the sum of free ortho and para aromatic groups with respect to the corresponding reference resin without a modification reagent. The later the modifier was added to the resin condensation mixture, the more methylene bridges were formed with respect to the amounts of free ortho and para aromatic groups. In addition, when urea or wheat starch was added in the later condensation stage, the final condensation also reached high stages. The modifications with lignosulfonate and starch, as well as the early addition of urea, enhanced p – p ′ bridge structures. The lowest condensation stage and, therefore, the highest reactivity were found when wheat starch was added with the starting reagents. The curing heat of the wheat‐starch‐modified resins decreased according to the deferred addition point of starch. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 582–588, 2003
Aging Changes in CD®-1 HaM/ICR Mice Reared Under Standard Laboratory Conditions 2 (1975)

Three hundred CD-1 HaM/ICR mice were observed for 2 years, and useful necropsies were done on 99 males and 102 females. Mortality was 50% at 16 months in the males and 18 months in the females. Among mice that came to autopsy, total tumor incidence was 54% for males and 75% for females, with most neoplasms occurring after 18 months. Adenomas or adenocarcinomas of the lung were the most frequent, followed by lymphoreticular tumors, vascular tumors, hepatomas, subcutaneous fibrosarcomas, and adenocarcinomas of the mammary glands. Some degree of amyloidosis was seen in half the mice of both sexes, beginning at 8 months in males and 12 months in females. Variability in tumor incidence among small groups if mice emphasized the need for adequate samples.
Implications of Active Site Constraints on Varied DNA Polymerase Selectivity (2002)

DNA polymerase selectivity often varies significantly depending on the DNA polymerase. The origin of this varying error propensity is elusive. It is assumed that DNA polymerases form nucleotide binding pockets that differ in properties such as shape and tightness. We tested this prediction and studied HIV-1 RT by employment of size-augmented nucleotides and site-directed mutagenesis of the enzyme. New valuable insights into the mechanism of DNA polymerase fidelity were obtained. The presented study provides experimental evidence that variations of steric constraints within the nucleotide binding pocket of at least two DNA polymerases cause variations in nucleotide incorporation selectivity. Thus, our results support the concept of active site tightness as a causative in differential fidelity among DNA polymerases.
<title>New generation control system for ultra-low-jitter satellite tracking</title> (1991)

The design of a new, all-digital control system for sub-arc second satellite tracking is described. This design is currently being reduced to practice for a large ground-based tracking telescope. Topics discussed include selection of overall control system architecture, the use of auxiliary inertial feedback elements for jitter reduction, sensor noise characterization, selection of bandwidth, hardware selection, and performance prediction. Experimental work is being conducted to support the development of this control system on a Contraves KINETO tracking system. A comparison of results (primarily tracking jitter and pointing accuracy) between a standard KINETO and the new control system is provided, as well as extrapolation of these results to the final system.
Prolastin aerosol therapy and sputum taurine in cystic fibrosis. (2006)

Aerosol therapy with Prolastin in patients with cystic fibrosis leads to a progressive decrease in sputum taurine. This suggests that even in the absence of sustained elastase inhibition, Prolastin aerosol therapy may have a beneficial effect on airway inflammation in patients with cystic fibrosis.
Flexible OLEDs for Automobiles using SiNx/CNx:H Multi-layer Barrier Films and Epoxy Substrates (2006)

Organic light emitting diodes (OLEDs) with thin-film passivation and plastic substrates are expected to provide a means of producing next-generation flat-panel displays that are thin, lightweight, and flexible. Thick silicon nitride (SiNx) films fabricated by a plasma-CVD method are already recognized as being a practical passivation film for OLEDs, but these are not suitable for flexible applications for automobiles as cracks are generated in the films as a result of the bending or thermal stress. To overcome this problem, we have developed plasma-CVD SiNx/ plasma-polymerized hydrogenated carbon nitride (CNx:H) multi-layer films and epoxy substrates that increase the longevity of passivated OLEDs in flexible applications for automobiles. The films exhibit a high barrier performance against moisture even in high stress conditions, because the stress in the films is released by the soft CNx:H layers and no cracks are produced. The epoxy substrates also show good stability at high temperatures because of their high glass transition temperature. Indeed, the OLED thus formed lasted over 1000 hours in driving tests at 85oC, that is the temperature which can arise in automobiles.
On the Application of Probability Theory to Agricultural Experiments. Essay on Principles. Section 9 (1990)

In the portion of the paper translated here, Neyman introduces a model for the analysis of field experiments conducted for the purpose of comparing a number of crop varieties, which makes use of a double-indexed array of unknown potential yields, one index corresponding to varieties and the other to plots. The yield corresponding to only one variety will be observed on any given plot, but through an urn model embodying sampling without replacement from this doubly indexed array, Neyman obtains a formula for the variance of the difference between the averages of the observed yields of two varieties. This variance involves the variance over all plots of the potential yields and the correlation coefficient $r$ between the potential yields of the two varieties on the same plot. Since it is impossible to estimate $r$ directly, Neyman advises taking $r = 1$, observing that in practice this may lead to using too large an estimated standard deviation, when comparing two variety means.
Distinct Expression Pattern of Cytokines in Semen of Men with Genital Infection and Oligo‐Terato‐Asthenozoospermia (2002)

The measurement of each cytokine separately in the SP of men with INF-OTA, in spite of the existing significant differences, does not have a diagnostic value in male infertility. However, a combined determination of IL-6, IL-8, IL-11 in the SP of men with genital infection and oligo-terato-asthenozoospermia may provide clinically useful information for the diagnosis of male accessory gland infection.
CD40 signaling induces B cell responsiveness to multiple members of the γ chain-common cytokine family (1999)

CD40 signaling induces B cell proliferative and differentiation responses that can be modulated by many different cytokines. Cytokines in the IL-2 receptor gamma chain (gammac)-common family are known to play an integral role in B cell development. Therefore, we investigated the possibility that CD40 signaling induced B cell responsiveness to multiple gammac-common cytokines and that individual gammac-common cytokines induced distinct B cell responses. B cells were isolated from lymphoid follicles of sheep Peyer's patches (PP) and co-cultured with murine CD40 ligand (mCD40L). CD40 signaling induced PP B cell responsiveness to recombinant human IL-2, IL-4, IL-7 and IL-15. mCD40L-induced B cell growth was enhanced by combining IL-4 with a second gammac-common cytokine and sustained B cell growth required co-stimulation with IL-4 plus IL-2, IL-7 and IL-15. gammac-common cytokine responsiveness remained dependent upon CD40 signaling, and removal of mCD40L resulted in B cell differentiation and cell death. Similar proliferative responses to mCD40L and gammac-common cytokines were observed for both immature (ileal) and mature (jejunal) PP B cells. Finally, the capacity of CD40-activated B cells to respond to multiple gammac-common cytokines was analyzed with individual PP B cell clones. All B cell clones displayed similar proliferative responses to IL-2 but quantitatively different responses to IL-4, IL-7 and IL-15. The biological significance of B cell responsiveness to multiple gammac-common cytokines is discussed.
Diagnostic Usefulness of the ABCD <sup>2</sup> Score to Distinguish Transient Ischemic Attack and Minor Ischemic Stroke From Noncerebrovascular Events (2009)

The ABCD(2) score had significant diagnostic usefulness for discrimination of true TIA and MIS from noncerebrovascular events, which may contribute to its predictive usefulness.
Exploration Of Prehospital Vital Sign Trends For The Prediction Of Trauma Outcomes (2010)

Our findings add to a growing body of evidence that prehospital vital sign trends over 21 minutes or less are unlikely to be diagnostically useful because of substantial nondirectional fluctuations in vital signs that would obscure any subtle, progressive temporal trends. SBP, RR, and SI values were significantly different for high-acuity patients, and had more variability. Taken together, these findings suggest that higher-acuity patients experience episodes of instability rather than gradual, steady decline. Measures that account for data variability, such as taking the average of multiple measurements, may improve the diagnostic utility of prehospital vital signs.
Acute Cytotoxic Effects of Photoimmunotherapy Assessed by <sup>18</sup>F-FDG PET (2013)

Immediate cytotoxic effects induced by photoimmunotherapy were clearly detected by decreased glucose uptake using (18)F-FDG PET even before changes in tumor size became evident. (18)F-FDG allows the clinical assessment of the therapeutic effects of photoimmunotherapy earlier than anatomic methods that rely on tumor size.
Homozygosity for a Novel Missense Mutation in the Prothrombin Gene Causing a Severe Bleeding Disorder (1994)

A patient with a severe bleeding tendency and hypoprothrombinemia (Factor II activity 2%, Factor II antigen 5%) was screened for the presence of alterations in his prothrombin gene. Direct sequencing of PCR fragments derived from the coding and flanking regions of the prothrombin gene, revealed that the patient was homozygous for an A-->G substitution in exon 3. This substitution predicts the replacement of Tyr44 (TAC) by Cys (TGC) in the prothrombin molecule. Both parents were found to be heterozygous for the same mutation. Further family studies revealed complete cosegregation of the mutation with the prothrombin deficiency. Only the five homozygous brothers and sisters of the propositus were clinically affected (severe hemorrhages including epistaxis, soft tissue, muscle and joint bleedings in all, and severe hemorrhages in the two women). The bleeding tendency therefore seems to inherit as an autosomal recessive trait.
Two-dimensional programmable optical neural network (1989)

A 2-D hybrid optical neural network using a high resolution video monitor as a programmable associative memory is proposed. Experiments and computer simulations of the system have been conducted. The high resolution and large dynamic range of the video monitor enable us to implement a hybrid neural network with more neurons and more accurate operation. The system operates in a high speed asynchronous mode due to the parallel feedback loop. The programmability of the system permits the use of orthogonal projection and multilevel recognition algorithms to increase the robustness and storage capacity of the network.
Attracted by Long-Range Electron Correlation: Adenine on Graphite (2005)

The adsorption of adenine on graphite is analyzed from first-principles calculations as a model case for the interaction between organic molecules and chemically inert surfaces. Within density-functional theory we find no chemical bonding due to ionic or covalent interactions, only a very weak attraction at distances beyond the equilibrium position due to the lowering of the kinetic energy of the valence electrons. Electron exchange and correlation effects are much more important for the stabilization of the adsystem. They are modeled by the local density or generalized gradient approximation supplemented by the London dispersion formula for the van der Waals interaction.
Terrain Analysis by Electromagnetic Means Technical Report, Nov. 1964 - Apr. 1965 (1966)

Radar sensor tests of effects of vegetation on detection and measurement of subsurface properties
pH-Dependent Single-Step Rapid Synthesis of CuO and Cu<sub>2</sub>O Nanoparticles from the Same Precursor (2014)

A single-step protocol to prepare Cu2O and CuO nanocrystalline particles from the same precursor by microwave irradiation has been developed using the pH of the solution as the only variable parameter. The utility of different bivalent Cu-precursors for synthesis of CuO and Cu2O nanoparticles was also investigated. The morphology, phase purity, and optical properties of these nanoparticles were analyzed using TEM, SEM, XRD, and optical spectroscopy. The band edges were determined using cyclic voltammetry. Field effect transistors based on CuO nanoparticles showed a hole mobility of 3.5 × 10–2 cm2 V–1 s–1, making them a suitable candidate for energy-related applications. The effect of hydrazine vapor exposure on the IV-characteristics of CuO nanoparticles was also investigated. This revealed a decrease in source current with respect to time.
APC/C-Mediated Degradation in Early Mitosis: How to Avoid Spindle Assembly Checkpoint Inhibition (2006)

The APC/C is an E3 ubiquitin ligase that, by targeting substrates for proteasomal degradation, plays a major role in cell cycle control. In complex with one of two WD40 activator proteins, Cdc20 or Cdh1, the APC/C is active from early mitosis through to late G1 and during this time targets many critical regulators of the cell cycle for degradation. However, this destruction is carefully ordered to ensure that cell cycle events are executed in a timely fashion. Recent studies have begun to shed light on how the APC/C selects different substrates at different times in the cell cycle. One particular problem is how the APC/C recognizes its first set of substrates, Nek2A and cyclin A, in early mitosis when, at this time, the spindle assembly checkpoint (SAC) inhibits most APC/C-dependent degradation. The answer may lie in how substrates are recruited to the APC/C. While checkpoint-dependent substrates appear to require Cdc20 for recruitment, experiments on the early mitotic substrate Nek2A demonstrate that it can bind the APC/C in the absence of Cdc20. The direct interaction of substrates with core subunits of the APC/C could allow their degradation to proceed unhindered even when the SAC is active.
Drug analysis at the 1988 Olympic Winter Games in Calgary. (1991)

A comprehensive drug testing program was carried out during the 16 days of the 1988 Olympic Winter Games in Calgary, Canada. State-of-the-art technology was applied, involving high-resolution gas chromatography, high-performance liquid chromatography, gas chromatography/mass spectrometry, fluorescence polarization immunoassay, and radioimmunoassay. Samples from selected athletes were screened for five drug classes: stimulants, narcotic analgesics, anabolic steroids, beta-blockers, and diuretics. In addition, samples were also screened for local anesthetics, corticosteroids, beta-human choriogonadotropin, and cannabinoids. During the 16-day event, 428 urine samples were processed and 3090 screening procedures performed. We describe the methods for analysis at the Olympic Games and present the results.
Synergistic effect of functionalized graphene oxide and carbon nanotube hybrids on mechanical properties of epoxy composites (2018)

Epoxy resin was grafted to graphene oxide (GO) <i>via</i> esterification reaction and 3D structure hybrids were prepared by combining 1D carbon nanotube (CNT) and 2D functionalized GO through π-stacking interaction. Epoxy composites filled with 3D structure hybrids were fabricated. The results show that functionalized GO effectively improves the dispersibility of CNTs in epoxy matrix due to good compatibility. Excellent mechanical properties were achieved by epoxy composites filled with 3D structure hybrids. The fracture surface analysis indicated improved interfacial interaction between 3D structure hybrids and epoxy matrix, which may due to the covalent bonding formed between the epoxy molecular chain grafted on EGO and the hardener agent during the curing process. In the 3D structure filler network, the mechanisms of crack deflection/bifurcation induced by functionalized GO make the crack path tortuous, which causes the cracks to encounter more CNTs and then promote the mechanisms of CNT fracture and crack bridging, resulting in more energy dissipation. This is the key mechanism for its excellent reinforcing and toughening effects.