gebhart/patrepeval huggingface dataset:
Contribution of CAF-I to Anaphase-Promoting-Complex-Mediated Mitotic Chromatin Assembly in <i>Saccharomyces cerevisiae</i> (2005)

The anaphase-promoting complex (APC) is required for mitotic progression and genomic stability. Recently, we demonstrated that the APC is also required for mitotic chromatin assembly and longevity. Here, we investigated the role the APC plays in chromatin assembly. We show that apc5(CA) mutations genetically interact with the CAF-I genes as well as ASF1, HIR1, and HIR2. When present in multiple copies, the individual CAF-I genes, CAC1, CAC2, and MSI1, suppress apc5(CA) phenotypes in a CAF-1- and Asf1p-independent manner. CAF-I and the APC functionally overlap, as cac1delta cac2delta msi1delta (caf1delta) cells expressing apc5(CA) exhibit a phenotype more severe than that of apc5(CA) or caf1delta. The Ts- phenotypes observed in apc5(CA) and apc5(CA) caf mutants may be rooted in compromised histone metabolism, as coexpression of histones H3 and H4 suppressed the Ts- defects. Synthetic genetic interactions were also observed in apc5(CA) asf1delta cells. Furthermore, increased expression of genes encoding Asf1p, Hir1p, and Hir2p suppressed the apc5(CA) Ts- defect in a CAF-I-dependent manner. Together, these results suggest the existence of a complex molecular mechanism controlling APC-dependent chromatin assembly. Our data suggest the APC functions with the individual CAF-I subunits, Asf1p, and the Hir1p and Hir2p proteins. However, Asf1p and an intact CAF-I complex are dispensable for CAF-I subunit suppression, whereas CAF-I is necessary for ASF1, HIR1, and HIR2 suppression of apc5(CA) phenotypes. We discuss the implications of our observations.
Wireless screenning of degradation kinetics in pharmaceutical gelatin films (2015)

We have developed a wireless sensing scheme for rapid screening of gelatin film physical degradation. The technique presents a new method for delineating the initial swelling (capacitive change) and subsequent dissolution (inductive change) phases. This is accomplished by incorporating super-paramagnetic nanoparticles into a gelatin film that is immobilized on top of a planar inductor. The degradation kinetics are measured wirelessly to identify the swelling and dissolution phases with sensitivities of 2313.4 kHz per absorbance unit during the first 60 minutes and 2214.2 kHz per absorbance unit from 60 minutes to 540 minutes.
Convolutional coding for direct sequence multicarrier CDMA (2002)

This paper presents a multicarrier asynchronous direct sequence (DS) code division multiple access (CDMA) system which, through the use of linear convolutional codes, achieves frequency diversity of an order above and beyond that realized by path diversity in a conventional RAKE DS-CDMA system. A frequency selective Rayleigh fading channel is decomposed into M frequency non-selective channels, based on the channel coherence bandwidth. Then, a rate 1/M convolutional code is used to modulate the M DS-CDMA waveforms. Diversity gains on the order of the code free distance may now be achieved. This system exhibits robust performance in the presence of narrowband interference and jamming, yet preserves the natural multiple access interference rejection properties inherent in the standard DS-CDMA model. Significant capacity gains over the single carrier system are demonstrated, while holding overall system bandwidth and information rates constant.
A Simple Laboratory Experiment for the Measurement of Single Phase Permeability (2007)

A simple experiment for measuring single-phase permeability of fully saturated porous medium is introduced. The experiment utilizes radial flow of a non-volatile wetting fluid through a porous medium such as ceramic tile, concrete or sand. The radial position of flow front is measured as a function of time and the collected data are analyzed using Darcy's Law to determine the permeability. In addition, the phenomenon of the multiphase flow through the medium with a broad pore size distribution is demonstrated.
The Role of IGF-1 Receptor and Insulin Receptor Signaling for the Pathogenesis of Alzheimers Disease: From Model Organisms to Human Disease (2009)

In different clinical studies, an association of type 2 diabetes and Alzheimer's disease (AD) has been described. However, the underlying mechanisms are still unclear. One explanation could be that vascular complications of diabetes result in neurodegeneration. Alternatively, the mechanism might be directly related to insulin and insulin-like growth factor(IGF)-1 signaling, leading to the proposal that AD is a "brain-type diabetes". Furthermore, postmortem analyses of brains from patients with AD revealed a markedly downregulated expression of insulin receptor (IR), IGF-1 receptor (IGF-1R), insulin receptor substrate (IRS)-1 and IRS-2, and these changes progress with severity of neurodegeneration. These findings raise the question, whether this phenomenon is cause or consequence of neurodegeneration. Recently, Cohen and coworkers have show that knocking down DAF-2 in C. elegans, the homolog of the mammalian IR/IGF-1R, reduces beta-amyloid(Abeta)(1-42) toxicity. Cell based experiments suggest a specific role for the IGF 1/IRS-2 signaling pathway in regulating alpha-/beta-secretase activity. Moreover circulating IGF-1 might influence Abeta clearance from the brain by promoting Abeta transport over the blood brain barrier. Interestingly, brain specific deletion of IRS-2 increases life span, suggesting that long term neuronal IGF-1R signaling might be harmful. Taken together, the data from humans and different model organisms indicate a role of IR/IGF-1R signaling in Abeta metabolism, and clearance as well as longevity. Since more studies are needed to elucidate the impact of insulin and/or IGF-1 treatment in AD, the time to propose these hormones as a potential treatment option for AD has not come yet.
First-principles study of intrinsic point defects in ZnO: Role of band structure, volume relaxation, and finite-size effects (2006)

Density-functional theory (DFT) calculations of intrinsic point defect properties in zinc oxide were performed in order to remedy the influence of finite-size effects and the improper description of the band structure. The generalized gradient approximation (GGA) with empirical self-interaction corrections $(\mathrm{GGA}+U)$ was applied to correct for the overestimation of covalency intrinsic to GGA-DFT calculations. Elastic as well as electrostatic image interactions were accounted for by application of extensive finite-size scaling and compensating charge corrections. Size-corrected formation enthalpies and volumes as well as their charge state dependence have been deduced. Our results partly confirm earlier calculations but reveal a larger number of transition levels: (1) For both the zinc interstitial as well as the oxygen vacancy, transition levels are close to the conduction band minimum. (2) The zinc vacancy shows a transition rather close to the valence band maximum and another one near the middle of the calculated band gap. (3) For the oxygen interstitials, transition levels occur both near the valence band maximum and the conduction band minimum.
A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia (2017)

GPR15 is an orphan G protein-coupled receptor (GPCR) that is found in lymphocytes. It functions as a co-receptor of simian immunodeficiency virus and HIV-2 and plays a role in the trafficking of T cells to the lamina propria in the colon and to the skin. We describe the purification from porcine colonic tissue extracts of an agonistic ligand for GPR15 and its functional characterization. In humans, this ligand, which we named GPR15L, is encoded by the gene <i>C10ORF99</i> and has some features similar to the CC family of chemokines. <i>GPR15L</i> was found in some human and mouse epithelia exposed to the environment, such as the colon and skin. In humans, <i>GPR15L</i> was also abundant in the cervix. In skin, <i>GPR15L</i> was readily detected after immunologic challenge and in human disease, for example, in psoriatic lesions. Allotransplantation of skin from <i>Gpr15l</i>-deficient mice onto wild-type mice resulted in substantial graft protection, suggesting nonredundant roles for GPR15 and GPR15L in the generation of effector T cell responses. Together, these data identify a receptor-ligand pair that is required for immune homeostasis at epithelia and whose modulation may represent an alternative approach to treating conditions affecting the skin such as psoriasis.
Uniform‐scale chromaticity diagrams: Opponent‐chromatic responses as logarithms of the cone‐activation ratios (1998)

Chromatic-response functions and a uniform-scale chromaticity diagram are derived by assuming that normal trichromatic vision is obtained by combining tritanopic and deuteranopic vision. Two different opponent-chromatic mechanisms can be related to these two dichromatic visions. The chromatic-response functions obtained are the logarithms of proper cone-activation ratios (CAR). Each opponent-chromatic mechanism consists of two parts separated by a properly defined neutral point that depends on the surround chromaticity. The Abney-hue shift, the wavelength discrimination for trichomats, deuteranopes, and tritanopes, and the threshold purity are well reproduced. © 1998 John Wiley & Sons, Inc. Col Res Appl, 23, 27–38, 1998
Flat-plate drag measurements with vortex generators in turbulent boundary layer (1983)

Direct drag measurements were obtained on a flat plate with a spanwise row of vortex generators near the leading edge, to produce an array of stream wise vortices within the approaching turbulent boundary layer. The object was to explore the possibility of modifying the large scale structure of the boundary layer through embedded longitudinal vortices with a view to obtaining a reduction in wall shear. Both obstacle and vane type vortex generators were tested at free stream velocities 40 ft/sec to 130 ft/sec corresponding to plate length Reynolds no. 0.3 million to 0.8 million with a nominal boundary layer thickness of approximately 0.6 in. at the leading edge. A few vortex generator configurations were tested both on and off the plate to measure the total drag as well as the plate drag alone. The obstacle type devices reduced the plate drag, indicating that the wake momentum defect predominated even in the presence of streamwise vortices. The vane type vortex generators however always increased the plate drag.
Assessment of the quality of the childhood physical abuse measure in the National Population Health Survey. (2015)

Despite some limitations, the NPHS question on childhood physical abuse allows researchers to investigate long-term health consequences of abuse.
Significant improvement in crystalline quality of molecular beam epitaxially grown GaAs on Si (100) by rapid thermal annealing (1986)

Rapid thermal annealing (RTA) has been found to significantly improve the crystalline quality of epitaxial GaAs grown on Si (100) substrates. After RTA at 900 °C for 10 s, the percentage of displaced atoms near the GaAs/Si interface, as estimated by Rutherford backscattering/channeling, decreased from 20 to 7%. Photoluminescence intensity (PL) after RTA increased significantly (as much as sixfold in some cases), with the actual increase varying from sample to sample and with annealing conditions. In some cases, the PL intensity after RTA was comparable to the PL intensity obtained from GaAs grown on GaAs substrate under similar conditions. Rapid thermal annealing at 940 °C resulted in a degradation of the PL intensity as compared to annealing at 900 °C. Also, the PL peaks after RTA were found to shift to lower energies by 2–5 meV at low temperatures.
`피동접미사 + -아/어지-`구성에 대하여 (2017)

The purpose of the present study is to elucidate the characteristics of the construction where both a passive suffix and “-a/eoji-” combine with a transitive verb, which is commonly called the double passive construction. If discussions in earlier research premised the identity of data-sets and explored their semantic functions, this study sought to go inside the sets and to reveal the differences among expressions. In order to be able to use these data for research, it is first necessary to distinguish what has gained force and what has not. Based on newspaper data, the present study confirmed the frequency and patterns of the appearance of the “-hi- + -eoji-” construction, specifically which expressions could be seen as having secured currency, and whether the grammaticality of expressions that appear with comparative frequency was of a level that Korean speakers could agree as natural. In addition, this study examined the contexts in which the major expressions appeared and the semantic functions of these expressions.
A Fully-Integrated High-Power Linear CMOS Power Amplifier With a Parallel-Series Combining Transformer (2012)

In this paper, a linear CMOS power amplifier (PA) with high output power (34-dBm saturated output power) for high data-rate mobile applications is introduced. The PA incorporates a parallel combination of four differential PA cores to generate high output power with good efficiency and linearity. To implement an efficient on-chip power combiner in a small form-factor, we propose a parallel-series combining transformer (PSCT), which mitigates drawbacks and limitations of conventional power-combining transformers such as a series combining transformer (SCT) and a parallel combining transformer (PCT). Using the proposed PSCT, a two-stage class-AB PA is designed and fabricated in a 0.18-μm CMOS technology. The PA achieves a P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1dB</sub> of 31.5 dBm , a P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sat</sub> of 34 dBm, and a P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">linear</sub> of 23.5 dBm with a peak PAE of 34.9% (peak drain efficiency of 41%) at the operating frequency of 2.4 GHz . A detailed analysis of the proposed PSCT is introduced along with comparisons to the conventional monolithic power-combining transformers. A design methodology of the integrated CMOS PA is also presented.
Reference (1991)

Research Article| October 01 1991 Reference Don Willis, Don Willis Search for other works by this author on: This Site PubMed Google Scholar Ernest Callenbach Ernest Callenbach Search for other works by this author on: This Site PubMed Google Scholar Film Quarterly (1991) 45 (1): 49–51. https://doi.org/10.2307/1212679 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Don Willis, Ernest Callenbach; Reference. Film Quarterly 1 October 1991; 45 (1): 49–51. doi: https://doi.org/10.2307/1212679 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentFilm Quarterly Search This content is only available via PDF. Copyright 1991 The Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.
Design of a Temporary Optical Coupler Using Fiber Bending for Traffic Monitoring (2017)

We design a temporary optical coupler that extracts 1.25-Gbps optical signals for traffic monitoring. The temporary optical coupler employs a fiber bending technique that uses a receiving fiber to receive leaked signal light from a bent fiber. We optimize the bending condition and the receiving fiber to obtain a high extraction efficiency while keeping the bending loss below 2 dB. We also measure the bit error rates for the 1.25-Gbps signals and reveal that our temporary optical coupler extracts the 1.25-Gbps optical signals without any deterioration in signal quality. Finally, we confirm experimentally that we achieved traffic monitoring using a traffic monitoring system and our temporary optical coupler in a fiber-to-the-home access network system based on a gigabit Ethernet passive optical network.
Facile one‐pot/one‐step technique for preparation of side‐chain functionalized polymers: Combination of SET‐RAFT polymerization of azide vinyl monomer and click chemistry (2011)

Abstract An azido‐containing functional monomer, 11‐azido‐undecanoyl methacrylate, was successfully polymerized via ambient temperature single electron transfer initiation and propagation through the reversible addition–fragmentation chain transfer (SET‐RAFT) method. The polymerization behavior possessed the characteristics of “living”/controlled radical polymerization. The kinetic plot was first order, and the molecular weight of the polymer increased linearly with the monomer conversion while keeping the relatively narrow molecular weight distribution ( M w / M n ≤ 1.22). The complete retention of azido group of the resulting polymer was confirmed by 1 H NMR and FTIR analysis. Retention of chain functionality was confirmed by chain extension with methyl methacrylate to yield a diblock copolymer. Furthermore, the side‐chain functionalized polymer could be prepared by one‐pot/one‐step technique, which is combination of SET‐RAFT and “click chemistry” methods. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Photoreflectance characterization of ultrashallow junction activation in millisecond annealing (2010)

Photoreflectance (PR) provides an optical means for rapid and precise measurement of near-surface electric fields in semiconductor materials. This article details the use of PR to characterize dopant activation in ultrashallow junction (USJ) structures formed using millisecond annealing processes. USJ structures were formed in silicon using 500eV B implantation with a dose of 1015∕cm2, followed by flash anneals at 1250–1350°C. Reference metrology was performed using secondary ion mass spectrometry and various sheet resistance (Rs) methods. Methods to calibrate PR signals to active carrier concentration in USJ structures, including halo-doped samples, are described. PR is shown to be highly sensitive to active dopant concentrations in USJ structures formed by millisecond annealing.
Plasma adenosine deaminase<sub>2</sub>, is a marker for human immunodeficiency virus‐1 seroconversion (1991)

Plasma adenosine deaminase2 (ADA2) has recently been proposed to be a marker for human immunodeficiency virus-1 (HIV) infection. We measured ADA2 levels in plasma from two groups of white homosexual males at 6-month intervals for a total of 2.5 years. One group consisted of 6 subjects who seroconverted for HIV, and the other consisted of 8 HIV seropositive patients who progressed from asymptomatic (CDC Groups II/III) to symptomatic (CDC Group IV) disease. Seroconversion was associated with a significant increase in plasma ADA2 which persisted throughout follow-up of 1.5 years. However, disease progression in HIV seropositive patients was not associated with any significant change in plasma ADA2. In conclusion, ADA2 may represent a unique marker for HIV seroconversion which does not change with later progression to symptomatic disease.
Radiation characteristics of zeroth-order resonators composed of 2-D dielectric-based composite right/left handed metamaterial structures (2009)

Zeroth-order resonators composed of 2-D dielectric-based composite right/left handed (CRLH) metamaterial structures and their radiation characteristics are investigated. The balanced CRLH structures are designed and fabricated to excite the zeroth-order resonance for the large scale size. The radiation characteristics of the resonators for several configurations with different number of unit cells are numerically simulated and measured. The measurement results are in good agreement with the numerical results, and validate the enhancement of the radiation directivity and gain with the increase in the number of the unit cells.
Synchronous Generator Modelling and Analysis for a Microgrid in Autonomous and Grid Connected Mode (2011)

Distributed generation is constructed on the basis of decentralized generation of electricity close to consumption sites using Distributed Generation (DG) sources. An optimized way to utilize the emerging potential of the distributed generation is to consider generation and its associated loads as a subsystem called "microgrid". A microgrid comprises of multiple DG units in close electrical proximity to one another. During disturbances the generation and the corresponding loads can separate from the distribution system to isolate the microgrid"s loads from the disturbance and thereby maintaining the service without harming the integrity of transmission grid. This work elaborates in detail the modeling and analysis of the Synchronous Generator that is connected to the microgrid which is the considered as one of the DGs. The modeling has been done in MATLAB/SIMULINK by integrating all the sub-models which include exciter, turbine and governor and the electrical part.
Prolonging Small Feeding Volumes Early in Life Decreases the Incidence of Necrotizing Enterocolitis in Very Low Birth Weight Infants (2003)

Given that advancing feeding volumes increase the risk of NEC without providing benefits for motor function or feeding tolerance, neonatologists should consider using minimal feeding volumes until future trials assess the safety of advancing feeding volumes.
Devitrified Barium Titanate Dielectrics (1966)

Pure barium titanate was made into a glass by flame‐spraying and after sufficient comminution was processed into specimens and fired. During this firing the glass devitrified to tetragonal barium titanate and contained crystals of sizes from 0.5 to below 0.2μ. The small crystals exhibit Curie temperatures from 120° to above 185°C. The dielectric Curie temperature of the devitrified ceramic is 150° to 155°C.
Folate Receptor Beta Designates Immunosuppressive Tumor-Associated Myeloid Cells That Can Be Reprogrammed with Folate-Targeted Drugs (2020)

Although immunotherapies of tumors have demonstrated promise for altering the progression of malignancies, immunotherapies have been limited by an immunosuppressive tumor microenvironment (TME) that prevents infiltrating immune cells from performing their anticancer functions. Prominent among immunosuppressive cells are myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM) that inhibit T cells via release of immunosuppressive cytokines and engagement of checkpoint receptors. Here, we explore the properties of MDSCs and TAMs from freshly isolated mouse and human tumors and find that an immunosuppressive subset of these cells can be distinguished from the nonimmunosuppressive population by its upregulation of folate receptor beta (FRβ) within the TME and its restriction to the TME. This FRβ<sup>+</sup> subpopulation could be selectively targeted with folate-linked drugs. Delivery of a folate-targeted TLR7 agonist to these cells (i) reduced their immunosuppressive function, (ii) increased CD8<sup>+</sup> T-cell infiltration, (iii) enhanced M1/M2 macrophage ratios, (iv) inhibited tumor growth, (v) blocked tumor metastasis, and (vi) improved overall survival without demonstrable toxicity. These data reveal a broadly applicable strategy across tumor types for reprogramming MDSCs and TAMs into antitumorigenic immune cells using a drug that would otherwise be too toxic to administer systemically. The data also establish FRβ as the first marker that distinguishes immunosuppressive from nonimmunosuppressive subsets of MDSCs and TAMs. Because all solid tumors accumulate MDSCs and TAMs, a general strategy to both identify and reprogram these cells should be broadly applied in the characterization and treatment of multiple tumors. SIGNIFICANCE: FRβ serves as both a means to identify and target MDSCs and TAMs within the tumor, allowing for delivery of immunomodulatory compounds to tumor myeloid cells in a variety of cancers.