gebhart/patrepeval huggingface dataset:
Drilling Optimization Using Bit Selection Expert System and ROP Prediction Algorithm Improves Drilling Performance and Enhances Operational Decision Making by Reducing Performance Uncertainties (2004)

Abstract A rule based drill bit selection expert software system and Rate of Penetration (ROP) prediction algorithm has been recently applied in the optimization process of a 4500 m vertical foothills well in Western Canada. Post well analysis shows that when the expert system recommendations were followed by the operator, increases in ROP and run length over the local pacesetter well were experienced in each hole section. ROP increases of 15% in the 311.1mm section, 52% in the 215.9mm section and 60% in the 142.9mm section were achieved, as well as bit life increases up to 33% with TCI bits. Although the operator did not follow all of the expert system recommendations through the entire well, these increases did contribute to savings in drilling time below AFE of 15 days over the entire well. Comparison with the actual drilling performance showed close agreement in trend to the predicted ROP through most lithological intervals, which helped to confirm the accuracy of the process of geological / pore pressure predictions and the ROP prediction algorithm. The expert system is a rule based bit selection system that uses a detailed description of the drilling environment, including meter based lithology, synthetic wireline logs, predicted pore pressures and anticipated operating parameters of the well or hole interval being analyzed to produce a bit selection recommendation including IADC bit type and bit features. The ROP algorithm has been developed as a drilling optimization tool and attempts to model the technical limit ROP that can be expected through a given hole interval. The ROP algorithm uses as its inputs detailed lithological descriptions of the anticipated formations, hole size, mud weight, predicted pore pressure, bit type, and anticipated operating parameters to calculate an accurate meter based ROP prediction. The ROP algorithm has been applied in several drilling environments worldwide and comparisons with actual drilling performance have been used to modify the calculations and improve predictions. The ROP algorithm improves drilling decisions, and provides performance analysis while guiding financial planning. The ROP algorithm can be applied in the planning phase of a project to develop time curves based on expected performance and to compare and contrast potential bit/BHA types based on performance predictions. Furthermore, the ROP algorithm can be used in post-well analysis to identify areas where potential drilling performance was not achieved, and help in identifying improvements for future projects.
A Multitechnique Study of Liposome Adsorption on Au and Lipid Bilayer Formation on SiO<sub>2</sub> (2006)

We have used a new setup for parallel quartz crystal microbalance with dissipation (QCM-D) and surface plasmon resonance (SPR) measurements to measure the detailed kinetics of vesicle-to-bilayer transformation on SiO2 and vesicle adsorption on Au, respectively. The combination of SPR and QCM-D, complemented by atomic force microscopy measurements, has enabled a complete, time-resolved separation of vesicle and bilayer coverages, and thus, for the first time, allowed precise quantification of the critical surface coverage of vesicles needed for rupture. We furthermore demonstrate and quantify a previously undetected vesicle-size- and concentration-dependent loss of lipid material during the later stages of the process.
Survival of Hatchery-Reared Cutthroat Trout in an Alberta Stream (1952)

Gorge Creek, a typical small mountain trout stream in southwestern Alberta, was divided by fish-tight screens into two sections, each about three-quarter miles in length. The number of native trout in these was determined by marking and recapture. One section was left as a control. Into the other, 199 3-year-old and 201 2-year-old hatchery-reared cutthroat trout were liberated. Each of the planted trout was weighed and given a numbered Petersen tag before planting. Fish that died were removed daily and weighed. Daily angling was carried on to recapture, weigh, and again release as many as possible. One-third of the 3-year-old fish died, mainly in the first 2 weeks following planting. All lost weight for 40 days, apparently through inability to compete with the native population. By fall (about 100 days after planting) the survivors had regained their planted weights. All, or nearly all, of the 2-year-old fish died, apparently from a combination of shock and starvation. The native trout in the experimental section gained weight all summer and, by fall, were in as good condition as the native trout in the control section. Plans for planting hatchery-reared trout in sections of stream free of native trout, and for transplanting native trout into sections containing native trout are described.
Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin (2004)

Chemotherapeutic agents induce apoptosis in cancer cells through effects on multiple intracellular targets. Recent observations suggest that a consistent cellular response to chemotherapeutic agents of disparate classes is down-regulation of glycolytic metabolism. Inhibition of glycolytic activity has been linked to apoptotic induction in several models. The serine/threonine kinase Akt (protein kinase B) promotes both glycolytic metabolism and survival, and these functions have been shown to be linked. Because of its key role in both glycolysis and survival, we examined the function of Akt in the cellular response to cytotoxic agents. Following exposure to any of several chemotherapeutic agents, an initial up-regulation in endogenous Akt activity is rapidly suppressed. Using cells containing constitutively active myristoylated Akt, dominant-negative kinase-dead Akt, or an empty vector control, we show here that Akt activation markedly increases resistance to microtubule-directed agents, including vincristine, colchicine, and paclitaxel. Akt also maintains increased glycolytic rate in response to antimicrotubule treatment. Rapamycin inhibits Akt-mediated maintenance of glycolysis and therapeutic resistance, indicating that these effects are dependent on mammalian target of rapamycin (mTOR). Furthermore, an activated mTOR mutant confers resistance to antimicrotubule agents. Taken together, these observations suggest that activation of the Akt-mTOR signaling pathway can augment glucose utilization and promote resistance to chemotherapeutic agents that do not directly target metabolic regulation. These data provide insight into potentially synergistic combinations of anticancer therapies.
Variations of the dielectric constant of pzt ferroelectric ceramics with electric field (1973)

The electric field dependence of the dielectric constant and loss of PZT perovskite-type ceramics have been investigated. Measurements were performed at frequencies of 1, 10 and 100 kHz, and 1 MHz, at several temperatures below the Curie temperature. The bias characteristics of the dielectric constant have two peaks, related to the 180° domain reversal and the 90° domain rotations, and show a temperaturedependent asymmetry in the electric field direction. A dielectric relaxation is observed in the frequency dependence of the dielectric constant. A discussion of the results in terms of domain switching processes is presented.
Spark Plasma Sintering of Alumina (2002)

A systematic study of various spark plasma sintering (SPS) parameters, namely temperature, holding time, heating rate, pressure, and pulse sequence, was conducted to investigate their effect on the densification, grain‐growth kinetics, hardness, and fracture toughness of a commercially available submicrometer‐sized Al 2 O 3 powder. The obtained experimental data clearly show that the SPS process enhances both densification and grain growth. Thus, Al 2 O 3 could be fully densified at a much lower temperature (1150°C), within a much shorter time (minutes), than in more conventional sintering processes. It is suggested that the densification is enhanced in the initial part of the sintering cycle by a local spark‐discharge process in the vicinity of contacting particles, and that both grain‐boundary diffusion and grain‐boundary migration are enhanced by the electrical field originating from the pulsed direct current used for heating the sample. Both the diffusion and the migration that promote the grain growth were found to be strongly dependent on temperature, implying that it is possible to retain the original fine‐grained structure in fully densified bodies by avoiding a too high sintering temperature. Hardness values in the range 21–22 GPa and fracture toughness values of 3.5 ± 0.5 MPa·m 1/2 were found for the compacts containing submicrometer‐sized Al 2 O 3 grains.
Accelerating Deep Convolutional Networks using low-precision and sparsity (2016)

We explore techniques to significantly improve the compute efficiency and performance of Deep Convolution Networks without impacting their accuracy. To improve the compute efficiency, we focus on achieving high accuracy with extremely low-precision (2-bit) weight networks, and to accelerate the execution time, we aggressively skip operations on zero-values. We achieve the highest reported accuracy of 76.6% Top-1/93% Top-5 on the Imagenet object classification challenge with low-precision network\footnote{github release of the source code coming soon} while reducing the compute requirement by ~3x compared to a full-precision network that achieves similar accuracy. Furthermore, to fully exploit the benefits of our low-precision networks, we build a deep learning accelerator core, dLAC, that can achieve up to 1 TFLOP/mm^2 equivalent for single-precision floating-point operations (~2 TFLOP/mm^2 for half-precision).
The L-type calcium channel in the heart: the beat goes on (2005)

Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.
Designer Self‐Assembling Peptide Materials (2007)

Understanding of macromolecular materials at the molecular level is becoming increasingly important for a new generation of nanomaterials for nanobiotechnology and other disciplines, namely, the design, synthesis, and fabrication of nanodevices at the molecular scale from bottom up. Basic engineering principles for microfabrication can be learned through fully grasping the molecular self-assembly and programmed assembly phenomena. Self- and programmed-assembly phenomena are ubiquitous in nature. Two key elements in molecular macrobiological material productions are chemical complementarity and structural compatibility, both of which require weak and non-covalent interactions that bring building blocks together during self-assembly. Significant advances have been made during the 1990s at the interface of materials chemistry and biology. They include the design of helical ribbons, peptide nanofiber scaffolds for three-dimensional cell cultures and tissue engineering, peptide surfactants for solubilizing and stabilizing diverse types of membrane proteins and their complexes, and molecular ink peptides for arbitrary printing and coating surfaces as well as coiled-coil helical peptides for multi-length scale fractal structures. These designer self-assembling peptides have far reaching implications in a broad spectrum of applications in biology, medicine, nanobiotechnology, and nanobiomedical technology, some of which are beyond our current imaginations. [image: see text]
Hyperspectral video restoration using optical flow and sparse coding (2012)

Hyperspectral video acquisition is a trade-off between spectral and temporal resolution. We present an algorithm for recovering dense hyperspectral video of dynamic scenes from a few measured multispectral bands per frame using optical flow and sparse coding. Different set of bands are measured in each video frame and optical flow is used to register them. Optical flow errors are corrected by exploiting sparsity in the spectra and the spatial correlation between images of a scene at different wavelengths. A redundant dictionary of atoms is learned that can sparsely approximate training spectra. The restoration of correct spectra is formulated as an ℓ1 convex optimization problem that minimizes a Mahalanobis-like weighted distance between the restored and corrupt signals as well as the restored signal and the median of the eight connected neighbours of the corrupt signal such that the restored signal is a sparse linear combination of the dictionary atoms. Spectral restoration is followed by spatial restoration using a guided dictionary approach where one dictionary is learned for measured bands and another for a band that is to be spatially restored. By constraining the sparse coding coefficients of both dictionaries to be the same, the restoration of corrupt band is guided by the more reliable measured bands. Experiments on real data and comparison with an existing volumetric image denoising technique shows the superiority of our algorithm.
The camKK2/camKIV relay is an essential regulator of hepatic cancer (2015)

The CaMKK2/CaMKIV relay is an upstream regulator of the oncogenic mammalian target of rapamycin/ribosomal protein S6 kinase, 70 kDa, pathway, and the importance of this CaMKK2/CaMKIV axis in HCC growth is confirmed by the potent growth inhibitory effects of genetically or pharmacologically decreasing CaMKK2 activity; collectively, these findings suggest that CaMKK2 and CaMKIV may represent potential targets for hepatic cancer.
Identification of Selective Inhibitors for Human Neuraminidase Isoenzymes Using C4,C7-Modified 2-Deoxy-2,3-didehydro-<i>N</i>-acetylneuraminic Acid (DANA) Analogues (2013)

In the past two decades, human neuraminidases (human sialidases, hNEUs) have been found to be involved in numerous pathways in biology. The development of selective and potent inhibitors of these enzymes will provide critical tools for glycobiology, help to avoid undesired side effects of antivirals, and may reveal new small-molecule therapeutic targets for human cancers. However, because of the high active site homology of the hNEU isoenzymes, little progress in the design and synthesis of selective inhibitors has been realized. Guided by our previous studies of human NEU3 inhibitors, we designed a series of C4,C7-modified analogues of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) and tested them against the full panel of hNEU isoenzymes (NEU1, NEU2, NEU3, NEU4). We identified inhibitors with up to 38-fold selectivity for NEU3 and 12-fold selectivity for NEU2 over all other isoenzymes. We also identified compounds that targeted NEU2 and NEU3 with similar potency.
New NO‐Donors with Antithrombotic and Vasodilating Activities, XI: 2‐Nitrosiminobenzimidazoles (1995)

Thirteen 1,3-disubstituted title compounds were synthesized and tested for their antiplatelet activity (Born test, collagen). Three derivatives inhibited the platelet aggregation halfmaximally in concentrations < 20 mumol/L.
Streptococcus pneumoniae Serogroups 15 and 33 (2006)

Pneumococcal disease in children caused by penicillin-susceptible clones of serogroups 15 and 33 is increasing in the United States. Clinicians should consider replacement serotypes when encountered with invasive pneumococcal disease in vaccinated children.
Safety belt effectiveness versus crash types (1994)

Based on Fatal Accident Reporting System (FARS) data, safety belt effect- tiveness in preventing fatalities is investigated for the following five types of crashes: frontal, left, rear, right, and rollover. Passenger cars containing two occupants, a driver and a right front passenger, are included in this analysis. For each crash type, these cars containing the two occupants are classified into four categories according to the safety belt usage categories for the two front seat occupants, namely, both belted, both unbelted, and either one was belted but not both. Relative risks of driver and right front passenger fatalities are compared among these four cases. For each crash type, two independent estimates of safety belt effectiveness are obtained for drivers and for right front passengers. The weighted average of the two estimates is calculated for drivers and for right front passengers for the five crash types. Using FARS data starting 1978 throught 1983, safety belts are more effective in rollover accidents than in frontal collisions. In rollover accidents, safety belt effectiveness estimate for drivers is and that for right front passengers is , in which the error limits indicate one standard error. Sfety belt effectiveness estimates for drivers and right front passengers involved in frontal collisions are and , respectively. For left and right sided collisions and for both drivers and right-front-passengers, none of the four estimates are significantly different from 0%, statistically : however, when left and right sided collisions are combined with far sided occupants(drivers involved in right sided collisions and right front passengers involved in left sided collisions) safety belt effectiveness is significant, . For rear collisions, the estimate for drivers shows statistically significant positive effect, . while for right-front-passengers the estimate is not significantly different from 0%. These results show that a safety belt is an effective restraint system not only in frontal crashes but also in a variety of crashes.
Correspondence and Short Communications: Cerebral Metastases from Multiple Myeloma (1991)

Click to increase image sizeClick to decrease image sizeKey Words: Myelomaintracerebral lesionsradiotherapy
Optimal control of AlAs oxidation via digital alloy heterostructure compositions (2009)

A thorough study of wet thermal oxidation in AlAs/AlxGa1−xAs superlattices is presented. The results shown here demonstrate that the final oxidation depth can be finely tuned via the composition and thickness of AlxGa1−xAs into the digital alloy. A complete model of oxidation in these structures is proposed, relying on diffusion through the AlAs layer, its oxidation and an additional effect due to the AlxGa1−xAs intermediate barriers. This barrier contribution is shown to further improve the control of the oxidation rate, and thereby fabrication of sophisticated AlOx/GaAs integrated optoelectronic devices.
Permeability of silicone polymers to hydrogen (1991)

Abstract Permeability coefficients, P̄ , for H 2 in 10 different types of silicone polymer membranes were measured in the temperature range of 10.0–55.0°C and at pressures up to 100 psig (∼6.8 atm). The values of P̄ decrease slightly with increasing Δ p , the pressure difference across the membranes. The permeability of silicone polymers to H 2 increases with an increase in temperature; the values of the energy of activation for permeation are in the range of 1.4–4.3 kcal/mol. The substitution of different functional groups in the backbone and side chains of silicone polymers has similar effects on the permeability of the polymers to H 2 as observed in earlier studies with other light gases. P̄ for H 2 decreases with an increase in the bulkiness of the substituted functional groups. The substitution of SiO bonds with stiffer SiC bonds in the backbone chains also results in a considerable decrease in permeability.
MR Fingerprinting with chemical exchange (MRF-X) to quantify subvoxel T1 and extracellular volume fraction (2015)

Background MR Fingerprinting (MRF) [1] offers a novel approach for quantifying extracellular volume (ECV) in a single scan without contrast agent. Whereas conventional parameter mapping assumes chemical exchange occurs much faster than the experiment time scale, usually on the order of T1, MRF measurements are acquired every TR (less than 12ms). This project investigates the feasibility of a new MRF acquisition termed MRF-X, which takes chemical exchange effects into account, to generate voxel-wise maps of ECV and T1.
Expansion<i>in vitro</i>of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability (1997)

Elucidation of mechanisms that regulate hematopoietic stem cell self-renewal and differentiation would be facilitated by the identification of defined culture conditions that allow these cells to be amplified. We now demonstrate a significant net increase (3-fold, P < 0.001) in vitro of cells that are individually able to permanently and competitively reconstitute the lymphoid and myeloid systems of syngeneic recipient mice when Sca-1 + lin − adult marrow cells are incubated for 10 days in serum-free medium with interleukin 11, flt3-ligand, and Steel factor. Moreover, the culture-derived repopulating cells continued to expand their numbers in the primary hosts at the same rate seen in recipients of noncultured stem cells. In the expansion cultures, long-term culture-initiating cells increased 7- ± 2-fold, myeloid colony-forming cells increased 140- ± 36-fold, and total nucleated cells increased 230- ± 62-fold. Twenty-seven of 100 cultures initiated with 15 Sca-1 + lin − marrow cells were found to contain transplantable stem cells 10 days later. This frequency of positive cultures is the same as the frequency of transplantable stem cells in the original input suspension, suggesting that most had undergone at least one self-renewal division in vitro . No expansion of stem cells was seen when Sca-1 + TER119 − CD34 + day 14.5 fetal liver cells were cultured under the same conditions. These findings set the stage for further investigations of the mechanisms by which cytokine stimulation may elicit different outcomes in mitotically activated hematopoietic stem cells during ontogeny and in the adult.
Spatial chemical distance based on atomic property fields (2010)

Similarity of compound chemical structures often leads to close pharmacological profiles, including binding to the same protein targets. The opposite, however, is not always true, as distinct chemical scaffolds can exhibit similar pharmacology as well. Therefore, relying on chemical similarity to known binders in search for novel chemicals targeting the same protein artificially narrows down the results and makes lead hopping impossible. In this study we attempt to design a compound similarity/distance measure that better captures structural aspects of their pharmacology and molecular interactions. The measure is based on our recently published method for compound spatial alignment with atomic property fields as a generalized 3D pharmacophoric potential. We optimized contributions of different atomic properties for better discrimination of compound pairs with the same pharmacology from those with different pharmacology using Partial Least Squares regression. Our proposed similarity measure was then tested for its ability to discriminate pharmacologically similar pairs from decoys on a large diverse dataset of 115 protein-ligand complexes. Compared to 2D Tanimoto and Shape Tanimoto approaches, our new approach led to improvement in the area under the receiver operating characteristic curve values in 66 and 58% of domains respectively. The improvement was particularly high for the previously problematic cases (weak performance of the 2D Tanimoto and Shape Tanimoto measures) with original AUC values below 0.8. In fact for these cases we obtained improvement in 86% of domains compare to 2D Tanimoto measure and 85% compare to Shape Tanimoto measure. The proposed spatial chemical distance measure can be used in virtual ligand screening.