gebhart/patrepeval huggingface dataset:
Automatic babble recognition for early detection of speech related disorders (1998)

We have developed a program, the Early Vocalization Analyzer (EVA), that automatically analyxes digitized recordings of infant vocalizations. The purpose of such a system is to automatically and reliably screen infants who may be at risk for later communication problems. Applying the landmark detection theory of Stevens et al., for the recognition of features in adult speech, EVA detects syllables in vocalixations produced by typically developing six to thirteen month old infants. We discuss the differences between adult-specific code and code written to analyxe infant vocalixations and present the results of validity-testing.
Knowledge bases and agents for domain knowledge representation (2005)

This paper focuses on the implementation of domain models for problem solving. We assume that the implementation should preserve the form of the domain models, and particularly the division between the knowledge structure and its role toward the solving process. We propose therefore to implement domain models with both knowledge bases and domain agents. We define a domain agent model which is linked to a knowledge base. We describe the various abilities of this agent and how it has been implemented in a multi-agent system with the YAFOOL language.
Sequencing and analysis of the <i>Methylococcus capsulatus</i> (Bath) soluble methane monooxygenase genes (2000)

The soluble methane monooxygenase (sMMO) hydroxylase is a prototypical member of the class of proteins with non-heme carboxylate-bridged diiron sites. The sMMO subclass of enzyme systems has several distinguishing characteristics, including the ability to catalyze hydroxylation or epoxidation chemistry, a multisubunit hydroxylase containing diiron centers in its alpha subunits, and the requirement of a coupling protein for optimal activity. Sequence homology alignment of known members of the sMMO family was performed in an effort to identify protein regions giving rise to these unique features. DNA sequencing of the Methylococcus capsulatus (Bath) sMMO genes confirmed previously identified sequencing errors and corrected two additional errors, each of which was confirmed by at least one independent method. Alignments of homologous proteins from sMMO, phenol hydroxylase, toluene 2-, 3-, and 4-monooxygenases, and alkene monooxygenase systems revealed an interesting set of absolutely conserved amino-acid residues, including previously unidentified residues located outside the diiron active site of the hydroxylase. By mapping these residues on to the M. capsulatus (Bath) sMMO hydroxylase crystal structure, functional and structural roles were proposed for the conserved regions. Analysis of the active site showed a highly conserved hydrogen-bonding network on one side of the diiron cluster but little homology on the opposite side, where substrates are presumed to bind. It is suggested that conserved residues on the hydroxylase surface may be important for protein-protein interactions with the reductase and coupling ancillary proteins and/or serve as part of an electron-transfer pathway. A possible way by which binding of the coupling protein at the surface of the hydroxylase might transfer information to the diiron active site at the interior is proposed.
A Meta Model for Process Mining Data. (2005)

Abstract. Modern process-aware information systems store detailed information about processes as they are being executed. This kind of information can be used for very different purposes. The term process mining refers to the techniques and tools to extract knowledge (e.g., in the form of models) from this. Several key players in this area have developed sophisticated process mining tools, such as Aris PPM and the HP Business Cockpit, that are capable of using the information available to generate meaningful insights. What most of these commercial process mining tools have in common is that installation and maintenance of the systems requires enormous effort, and deep knowledge of the underlying information system. Moreover, information systems log events in different ways. Therefore, the interface between process-aware information systems and process mining tools is far from trivial. It is vital to correctly map and interpret event logs recorded by the underlying information systems. Therefore, we propose a meta model for event logs. We give the requirements for the data that should be available, both informally and formally. Furthermore, we back our meta model up with an XML format called MXML and a tooling framework that is capable of reading MXML files. Although, the approach presented in this paper is very pragmatic, it can be seen as a first step towards and ontological analysis of process mining data. 1
Relation of Cigarette Smoking to 25-Year Mortality in Middle-aged Men with Low Baseline Serum Cholesterol : The Chicago Heart Association Detection Project in Industry (2002)

It has been suggested that smoking does not influence risk of cardiovascular diseases in populations with low serum cholesterol levels. To determine whether cigarette smoking is an independent risk factor among men with low levels of serum cholesterol, data on 25-year coronary, cardiovascular, and all-cause mortality for 8,816 middle-aged men screened between 1967 and 1973 by the Chicago Heart Association Detection Project in Industry were examined. With Cox multivariate proportional hazards regression, relative risks of coronary heart disease and cardiovascular disease mortality associated with smoking for the two subcohorts with favorable levels of serum total cholesterol, that is, less than 180 and 180-199 mg/dl, were of the same magnitude as those for men with elevated serum cholesterol, that is, 200-239 and 240 mg/dl. In the two lower strata of cholesterol, the absolute risk and absolute excess risk of mortality for current smokers at baseline were substantially higher compared with men who never smoked, with all-cause death rates of 423.0 and 428.0 per 1,000 and absolute excess rates of 209.8 and 225.7 per 1,000. These translate to estimated shorter life expectancies of 5.3 and 5.7 years, respectively. Adverse effects of smoking on risk of coronary, cardiovascular, and all-cause mortality prevail for men with lower as well as higher serum cholesterol levels.
Two Distinct Mechanisms Cause Heterogeneity of 16S rRNA (1999)

To investigate the frequency of heterogeneity among the multiple 16S rRNA genes within a single microorganism, we determined directly the 120-bp nucleotide sequences containing the hypervariable alpha region of the 16S rRNA gene from 475 Streptomyces strains. Display of the direct sequencing patterns revealed the existence of 136 heterogeneous loci among a total of 33 strains. The heterogeneous loci were detected only in the stem region designated helix 10. All of the substitutions conserved the relevant secondary structure. The 33 strains were divided into two groups: one group, including 22 strains, had less than two heterogeneous bases; the other group, including 11 strains, had five or more heterogeneous bases. The two groups were different in their combinations of heterogeneous bases. The former mainly contained transitional substitutions, and the latter was mainly composed of transversional substitutions, suggesting that at least two mechanisms, possibly misincorporation during DNA replication and horizontal gene transfer, cause rRNA heterogeneity.
Dielectric post resonances in a rectangular waveguide (1990)

Dielectric post resonances are investigated using a combination of the finite and boundary element methods (CFBEM). A substructure method is adopted in the finite-element method (FEM), so the dimension of the matrix equation to be solved can be reduced. Some of the lossless dielectric post resonances in a rectangular waveguide can be physically realised by a lattice circuit, and it is found that there are two types of dielectric post resonances. Moreover, the variations of the post location are related to the variations of the branch reactances of the lattice circuit.
A statistical error detection technique for low bit-rate video (2002)

Multimedia services requiring image and video compression are now widely available over fixed telecommunications networks such as cable television networks and the Internet. In the future, these services will also be provided over wireless networks similar to those currently used for digital mobile telephony. As a consequence of the high bit error rates associated with these channels, special error-resilient coding techniques are required to achieve a satisfactory picture quality. An error detection scheme based on the detection of statistically incorrect information, is introduced. The new technique calculates statistical information about the video sequence currently being decoded and uses this information to detect and conceal macroblocks which have been incorrectly decoded. Simulation results show this technique provides a significant improvement in the decoded image quality while requiring no additional information to be transmitted to the decoder.
Pagination of B*-trees with variable-length records (1977)

A strategy is presented for pagination of B * -trees with variable-length records. If records of each length are uniformly distributed within the file, and if a wide distribution of record lengths exists within the file, then this strategy results in shallow trees with fast access times. The performance of this strategy in an application is presented, compared with that of another strategy, and analyzed.
Bayesian video matting using learnt image priors (2004)

Video matting, or layer extraction, is a classic inverse problem in computer vision that involves the extraction of foreground objects, and the alpha mattes that describe their opacity, from a set of images. Modem approaches that work with natural backgrounds often require user-labelled "trimaps" that segment each image into foreground, background and unknown regions. For long sequences, the production of accurate trimaps can be time consuming. In contrast, another class of approach depends on automatic background extraction to automate the process, but existing techniques do not make use of spatiotemporal consistency, and cannot take account of operator hints such as trimaps. This paper presents a method inspired by natural image statistics that cleanly unifies these approaches. A prior is learnt that models the relationship between the spatiotemporal gradients in the image sequence and those in the alpha mattes. This is used in combination with a learnt foreground colour model and a prior on the alpha distribution to help regularize the solution and greatly improve the automatic performance of such systems. The system is applied to several real image sequences that demonstrate the advantage that the unified approach can afford.
CMOS-MEMS multiple resonant vibration energy harvester for wireless sensor network (2015)

This paper presents the design, modeling, and simulation of a multiple resonant MEMS vibration energy harvester (VEH) suitable for wireless sensor network (WSN) applications. Since ambient vibration has a frequency of 100 Hz and below, a multiple resonant harvester will be an advantage to increase the vibration frequency and hence the output voltage produced by the device. The high frequency harvester is designed using CMOS technology capable of monolithically integration with any CMOS circuits. For a standard button battery size (16 × 16 × 5 mm3) harvester, simulation result shows that the harvester can provide peak voltage of 3.0 Volts at 20 Hz and 1 g vibration with a single high frequency oscillator. The series configuration of high frequency structures can provide multiple of 3.0 Volts output voltage.
[CPP32 expression and its significance in multidrug-resistant tumor cells and their parent cells]. (2002)

The apoptosis resistance of mdr cells is not related to the abnormality of CPP32 but the upstream of caspase, the fact of which indicates promising prospect of the research on reversion of mdr cells using CPP32 as target.
Flow-Motion and Depth Network for Monocular Stereo and Beyond (2020)

We propose a learning-based method <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> that solves monocular stereo and can be extended to fuse depth information from multiple target frames. Given two unconstrained images from a monocular camera with known intrinsic calibration, our network estimates relative camera poses and the depth map of the source image. The core contribution of the proposed method is threefold. First, a network is tailored for static scenes that jointly estimates the optical flow and camera motion. By the joint estimation, the optical flow search space is gradually reduced resulting in an efficient and accurate flow estimation. Second, a novel triangulation layer is proposed to encode the estimated optical flow and camera motion while avoiding common numerical issues caused by epipolar. Third, beyond two-view depth estimation, we further extend the above networks to fuse depth information from multiple target images and estimate the depth map of the source image. To further benefit the research community, we introduce tools to generate realistic structure-from-motion datasets such that deep networks can be well trained and evaluated. The proposed method is compared with previous methods and achieves state-of-the-art results within less time. Images from real-world applications and Google Earth are used to demonstrate the generalization ability of the method.
High-Quality Planar Alignment of Discotic Liquid Crystals Using Oscillating Shear (2013)

High-quality planar alignment was achieved in the hexagonal columnar phase of 2,3,6,7,10,11-hexahexyloxytriphenylene by applying an oscillating shear using a piezoelectric actuator. Discotic liquid crystals with thicknesses up to 38 µm could be aligned using this technique, with the molecular columns aligning parallel to the direction of the shear. The quality of the alignment was also found to be higher in this technique than in previously proposed alignment methods, since a higher retardation and a higher dichroic ratio were obtained.
Generation and characterization of monoclonal antibodies to 28-, 35-, and 65-kilodalton proteins of Mycobacterium tuberculosis (1988)

Three monoclonal antibodies (H60.15, H61.3, and H105.10) directed to protein antigens of Mycobacterium tuberculosis were obtained and characterized. H60.15 recognizes a protein with a molecular mass of 28 kilodaltons (kDa) with broad cross-reactivity on a panel of 12 species and strains of mycobacteria. H61.3 reacts with a 35-kDa protein present in M. tuberculosis, Mycobacterium bovis BCG, and M. africanum. On the basis of the antigen molecular masses and competition experiments with other monoclonal antibodies, H60.15 and H61.3 seem to be the first described monoclonal antibodies to these M. tuberculosis proteins. H105.10 binds to the cross-reactive 65-kDa protein present in mycobacteria. Epitope mapping of H105.10 was performed by using the M. leprae DNA sublibrary available in bacteriophage lambda gt11 for this antigen and revealed that its epitope resides in the region from amino acids 20 to 54. The 28-, 35-, and 65-kDa antigens isolated by immunoblotting and presented on nitrocellulose to pleural effusion T cells from tuberculosis patients induced a proliferative response, indicating the presence of T-cell epitopes. These observations indicate that two protein antigens should be added to the list of antigens detectable in M. tuberculosis by monoclonal antibodies. The common feature of such proteins, the elicitation of an immune response of limited or broad cross-reactivity for mycobacteria, encourages the search for their role in the pathogenesis of mycobacterioses.
<i>Arabidopsis</i> mutants with reduced response to NaCl and osmotic stress (1995)

We isolated 6 mutant lines of Arabidopsis thaliana that expressed reduced sensitivity to salt and osmotic stress during germination. All 6 lines cum recessive mutations in a single gene, designated reduced salt sensitivity (rss), linked to the ADH marker on chromosome 1. The rss mutants are less sensitive than wild type for NaCl and osmotic stress inhibition of germination, tolerating approximately 150 mM higher concentrations of NaCl and about 250 mM higher concentrations of sorbitol in the media. Germination assays on media containing various salts indicate that the rss mutations reduce sensitivity lo Na + and Rh + but also, to a much lesser degree, to K + and Cs s+ . However, the rss mutation does not improve plant growth when plantlets are transferred to high salt or high osmotic pressure media after germination. The rss plantlets accumulate praline to a significantly lesser degree than wild type when they are exposed to either salt or osmotic stress. Thus, the rss mutants differ from wild type both at germination and during vegetative growth indicating that the rss mutations are pleiotropic and might affect perception of solutes or some aspect of stress‐induced signaling. The rss mutations do not alter ABA sensitivity and therefore probably do not affect ABA‐mediated signaling.
Lack of Pharmacokinetic Drug Interaction between Tenofovir Disoproxil Fumarate and Nelfinavir Mesylate (2005)

A study explored the pharmacokinetics of tenofovir (300 mg administered once daily) and nelfinavir (1,250 mg twice daily) when coadministered in 29 healthy volunteers. Tenofovir, nelfinavir, and M8 pharmacokinetics was unaltered when tenofovir and nelfinavir were coadministered, and tenofovir administration did not affect the M8/nelfinavir area under the concentration-versus-time curve over the dosing interval (AUC(tau)) ratio. No interaction between tenofovir and nelfinavir was observed.
Fast subword permutation instructions based on butterfly networks (2000)

Many contemporary microprocessor architectures incorporate multimedia extensions to accelerate media-rich applications using subword arithmetic. While these extensions signicantly improve the performance of most multimedia applications, the lack of subword rearrangement support potentially limits performance gain. Several means of adding architectural support for subword rearrangement were proposed and implemented but none of them provide a fully general solution. In this paper, a new class of permutation instructions based on the buttery interconnection network is proposed to address the general subword rearrangement problem. It can be used to perform arbitrary permutation(without repetition) of n subwords within log n cycles regardless of the subword size. The instruction coding and the low-level implementation for the instructions are quite simple. An algorithm is also given to derive an instruction sequence for any arbitrary permutation. 1. INTRODUCTION The rapid growth of mult...
Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin alpha IIb beta 3. (1994)

PAC1 is an IgM kappa murine monoclonal antibody that, like the Arg-Gly-Asp-containing ligand fibrinogen, binds to integrin alpha IIb beta 3 only on activated platelets. The unique binding properties of PAC1 may be determined by its large size, its multivalency, and by variable region sequences, including an Arg-Tyr-Asp at residues 100A-C in H-CDR3. To study the molecular determinants of PAC1 function, baculoviruses containing cloned cDNA for the Fd heavy and kappa light chains of PAC1 were used to co-infect Sf9 insect cells. Infected cells secreted a soluble, monovalent, 50-kDa Fab fragment that bound saturably to agonist-stimulated platelets but not to resting cells. Fab binding was inhibited > 85% by 10 mM EDTA, 1 mM RGDS, 1 mM fibrinogen gamma 397-411, or 12 microM fibrinogen, but not by 1 mM RGES. Compared to PAC1 IgM, a 60-fold higher molar concentration of PAC1 Fab was required for half-maximal binding to platelets or for half-maximal inhibition of fibrinogen binding. PAC1 Fab bound to an activated form of alpha IIb beta 3 expressed in Chinese hamster ovary cells, but not to the resting form of the receptor in these cells or to alpha v beta 3 in human endothelial cells. Conversion of Asp100C to Glu by site-directed mutagenesis rendered the antibody inactive, indicating that the Arg-Tyr-Asp sequence in H-CDR3 is essential for PAC1 recognition of alpha IIb beta 3. Binding of fibrinogen or PAC1 IgM to platelets induced tyrosine phosphorylation of a 140-kDa platelet protein, but binding of PAC1 Fab did not. These studies demonstrate that the specificity of PAC1 for activated alpha IIb beta 3 is determined by an integrin recognition sequence within H-CDR3. However, the strength of this binding interaction and the ability of PAC1 to trigger signaling in platelets also depend on antibody valency.
Mechanisms in Insect Olfaction (1986)

V G Dethier: Chemoreception and behaviour from an evolutionary and comparative perspective BEHAVIOURAL MECHANISMS: J S Kennedy: Some current issues in orientation to odour sources J Murlis: The structure of odour plumes T C Baker: Pheromone-modulated movements of flying moths C T David: Mechanisms of directional flight in wind E Kramer: Turbulent diffusion and pheromone-triggered anemotaxis R Preiss & E Kramer: Pheromone-induced anemotaxis in simulated free flight R J Prokopy: Visual and olfactory stimulus interaction in resource finding by insects J N Perry & C Wall: The effect of habitat on the flight of moths orienting to pheromone sources J H Borden, D W A Hunt, D R Miller, & K N Slessor: Orientation in forest Coleoptera: an uncertain outcome of responses by individual beetles to variable stimuli T L Payne: Olfaction and vision in host finding by a bark beetle C J Sanders: The role of pheromone concentration on male moth flight behaviour J L fqvist: Species specificity in response to pheromone substances in diprionid sawflies J M Pasteels, J L Deneubourg, J-C Verhaeghe, J L Boev 'e, & U Quinet: Orientation along terrestrial trails by ants W J Bell: Responses of arthropods to temporal chemical stimulus changes: simulation of a humidity differential and a pheromone plume R L Jones: Orientation by insect parasitoids P E Howse, J C Lisk, & J W S Bradshaw: The role of pheromones in the control of behavioural sequences in insects J R McLaughlin: Manipulation of orientation to pheromones R J Bartell & E R Rumbo: Correlations between electrophysiological and behavioural responses elicited by pheromone R T Card 'e: Epilogue: behavioural mechanisms PHYSIOLOGICAL MECHANISMS: D Schneider: Physiology of insect olfaction - reflections on the last 30 years K E Kaissling: Temporal characteristics of pheromone receptor cell responses in relation to orientation behaviour of moths R G Vogt & L M Riddiford: Pheromone reception: a kinetic equilibrium C E Linn & W L Roelofs: Neuropharmacological effects on olfactory perception R J O'Connell: Electrophysiological responses to pheromone blends in single olfactory receptor neurones E Priesner: Correlating sensory and behavioural responses in multi-chemical pheromone systems of Lepidoptera J N C Van Der Pers & C L ofstedt: Signal-response relationship in sex pheromone communication E E Davis: Peripheral chemoreceptors and regulation of insect behaviour J C Dickens: Specificity in perception of pheromones and host odours in Coleoptera H Mustaparta: Allelochemical effects of pheromones: receptor responses F E Hanson, S Kogge, & C Cearley: Computer analysis of chemosensory signals J G Hildebrand & R A Montague: Functional organization of olfactory pathways in the central nervous system of Manduca sexta D M Light: Central integration of sensory signals: an exploration of processing of pheromonal and mult