gebhart/patrepeval huggingface dataset:
Dynamic video playout smoothing method for multimedia applications (2002)

Multimedia applications including video data require the smoothing of video playout to prevent potential playout discontinuity. In this paper, we propose a dynamic video playout smoothing method, called the video smoother, which dynamically adopts various playout rates in an attempt to compensate for high delay variance of networks. Specifically, if the number of frames in the buffer exceeds a given threshold (TH), the smoother employs a maximum playout rate. Otherwise, the smoother uses proportionally reduced rates in an effort to eliminate playout pauses resulting from the emptiness of the playout buffer. To determine THs under various loads, we present an analytic model assuming the Poisson process arrival correspondent with a network with a traffic shaper. Based on the analytic results, we establish a paradigm of determining THs and playout rates for achieving different playout qualities under various loads of networks. Finally, to demonstrate the viability of the video smoother, we have implemented a prototyping system including a multimedia teleconferencing application and the video smoother performing as a part of the transport layer. The prototyping results show that the video smoother achieves smooth playout incurring only unnoticeable delays.
Collagenase for Enzymatic Debridement (2009)

Debridement is an essential component of wound bed preparation. Various techniques of debridement are commonly used in clinical practice. This systematic review summarizes and ranks evidence concerning the safety and efficacy of the selective enzymatic debriding agent collagenase. Studies were identified comparing collagenase to inactive (sham) ointment and to alternate techniques for debridement including autolytic and surgical. A preponderance of evidence from this systematic review confirms that collagenase ointment is a safe and effective choice for debridement of cutaneous ulcers and burn wounds.
Solid Mechanics Based Design and Optimization for Support Structure Generation in Stereolithography Based Additive Manufacturing (2015)

Support structures are typically required to hold parts in place in various additive manufacturing processes. Design of support structure includes identifying both anchor locations and geometries. Extensive work has been done to optimize the anchor locations to reliably keep part in position, and minimize the contacting area as well as the total volume of the support structures. However, relatively few studies have been focused on the mechanical property analysis of the structure. In this paper, we proposed a novel design optimization method to identify the anchor geometry based on solid mechanics theory. Finite element analysis method is utilized to study the stress distribution on both the support structure and main part. Particle Swarm Optimization (PSO) algorithm with a novel constraining handling strategy is employed to optimize the design model. A gradient descent local search algorithm is utilized to quickly locate the global solution in the vicinity explored by PSO. The developed optimization framework is deployed on a bottom-up projection based Stereolithography process. The experimental results show that the optimized design can efficiently reduce the material used on support structure and marks left on the part.
T‐cell dynamics after high‐dose chemotherapy in adults: elucidation of the elusive CD8<sup>+</sup> subset reveals multiple homeostatic T‐cell compartments with distinct implications for immune competence (2002)

Recovery of total T cell numbers after in vivo T-cell depletion in humans is accompanied by complex perturbation within the CD8+ subset. We aimed to elucidate the reconstitution of CD8+ T cells by separate analysis of putative naïve CD95- CD28+, memory CD95+ CD28+ and CD28- T cell compartments after acute maximal depletion by high-dose chemotherapy (HD-ChT) in women with high-risk breast cancer. We found that recovery of putative naïve CD8+ CD95- CD28+ and CD4+ CD95- CD28+ T cells, was compatible with a thymus-dependent regenerative pathway since their recovery was slow and time-dependent, their values were tightly related to each other, and their reconstitution patterns were inversely related to age. By analysing non-naïve T cells, a striking diversion between putative memory T cells and CD28- T cells was found. These latter increased early well beyond normal values, thus playing a pivotal role in total T-cell homeostasis, and contributed to reduce the CD4 : CD8 ratio. In contrast, putative memory T cells returned to values not significantly different from those seen in patients at diagnosis, indicating that this compartment may recover after HD-ChT. At 3-5 years after treatment, naïve T cells persisted at low levels, with expansion of CD28- T cells, suggesting that such alterations may extend further. These findings indicate that CD28- T cells were responsible for 'blind' T-cell homeostasis, but support the notion that memory and naïve T cells are regulated separately. Given their distinct dynamics, quantitative evaluation of T-cell pools in patients undergoing chemotherapy should take into account separate analysis of naïve, memory and CD28- T cells.
Fatty acid bioconversions by <i>Pseudomonas aeruginosa</i> PR3 (1998)

Abstract The bioconversions of oleic acid, linoleic acid, and ricinoleic acid by Pseudomonas aeruginosa PR3 were investigated. The conversion of oleic acid to 7,10‐dihydroxy‐8( E )‐octadecenoic acid (DOD) was improved to better than 80% yields by modifying the culture medium and reaction parameters. The microbial cultures were stable and retained the same level of DOD production capacity for up to 6 mon as examined herewith. Strain PR3 did not bioconvert linoleic acid. However, strain PR3 converted ricinoleic acid to a novel compound, 7,10,12‐trihydroxy‐8( E )‐octadecenoic acid (TOD), with a yield of about 35%. The product was further metabolized by strain PR3. TOD was purified by thin‐layer chromatography, and its structure was determined by 1 H and 13 C nuclear magnetic resonance and mass spectrometry. This is the first report on the production of 7,10,12‐trihydroxy unsaturated fatty acid by microbial transformation.
SurfNet: Generating 3D Shape Surfaces Using Deep Residual Networks (2017)

3D shape models are naturally parameterized using vertices and faces, i.e., composed of polygons forming a surface. However, current 3D learning paradigms for predictive and generative tasks using convolutional neural networks focus on a voxelized representation of the object. Lifting convolution operators from the traditional 2D to 3D results in high computational overhead with little additional benefit as most of the geometry information is contained on the surface boundary. Here we study the problem of directly generating the 3D shape surface of rigid and non-rigid shapes using deep convolutional neural networks. We develop a procedure to create consistent `geometry images' representing the shape surface of a category of 3D objects. We then use this consistent representation for category-specific shape surface generation from a parametric representation or an image by developing novel extensions of deep residual networks for the task of geometry image generation. Our experiments indicate that our network learns a meaningful representation of shape surfaces allowing it to interpolate between shape orientations and poses, invent new shape surfaces and reconstruct 3D shape surfaces from previously unseen images. Our code is available at https://github.com/sinhayan/surfnet.
QoS negotiation for IPTV service using SIP (2007)

This paper addresses QoS negotiation algorithm for IPTV services by using SIP. IPTV is defined as multimedia services such as television/video/audio/text/graphics/data delivered over IP based networks managed to provide the required level of QoS/QoE, security, interactivity and reliability by the ITU-T IPTV FG. As stated in its definition, IPTV provides the required level of QoS/QoE. To achieve this, IPTV service frameworks should be able to negotiate QoS/QoE with users or customers and SIP is one of the most proper methods for the SLA negotiation.
Capillary Gas Chromatographic Introduction of Environmental Compounds into a Trochoidal Electron Monochromator/Mass Spectrometer (1994)

A gas chromatograph was interfaced to an electron monochromator/quadrupole mass spectrometer. The new system was tested for the analysis of environmental compounds. Detection sensitivity for hexachlorobenzene (HCB) through the gas chromatograph was 5 pg or better, and a mass-resolved molecular ion cluster for this compound on the fly was achieved with 10.8 ng of sample. An ion chromatogram was obtained using 45 ng of Aroclor 1254, and the extract from a trout muscle sample recently collected in the Arctic yielded a chromatographic profile similar to that observed using negative ion chemical ionization mass spectrometry. A mixture of HCB and 2,4,6-trinitrotoluene (TNT) were shown to be distinguishable at 2.4-eV electron energy. The energetics of regioselective fragmentation of [4-15NO2]TNT by dissociative electron capture can be determined on the fly. Complete negative ion gas chromatography/mass spectrometry (GC/MS) spectra were obtained for hexafluorobenzene and TNT by simultaneously ramping the electron energy from -2 to 15 eV and scanning the mass over a 200-Da range.
Utility of pre-treatment neutrophil–lymphocyte ratio and platelet–lymphocyte ratio as prognostic factors in breast cancer (2015)

Both the NLR and PLR are independently associated with an increased risk of mortality in breast cancer. Their added value in the prognostication of breast cancer in clinical practice warrants investigation.
Design and Evaluation of a Novel Short Prototype Filter for FBMC/OQAM Modulation (2018)

Filter-bank multi-carrier with offset quadrature amplitude modulation (FBMC/OQAM) is considered by recent research projects as one of the key enablers for the future 5G air interface. It exhibits better spectral shape and improves mobility support compared to orthogonal frequency-division multiplexing (OFDM) thanks to the use of a time and frequency localized prototype filter. The choice of this filter is crucial for FBMC/OQAM, due to its substantial impact on achieved performance and complexity levels. In the context of 5G, short frame sizes are foreseen in several communication scenarios to reduce system latency, and therefore short filters are preferred. In this context, a novel short filter allowing for near perfect reconstruction and having the same size as one OFDM symbol is proposed. Using frequency-spread (FS) implementation for the FBMC/OQAM receiver, analytical analysis and simulation results show that the proposed filter exhibits better robustness to several types of channel impairments when compared to state-of-the-art prototype filters and OFDM modulation. In addition, FS-based hardware architecture of the filtering stage is proposed, showing lower complexity than the classical polyphase network-based implementation.
Effect of Growth Factors on Bovine Retinal Pigment Epithelial Cell Migration and Proliferation (2004)

The peptide growth factors PDGF, bFGF, aFGF, IGF-1, and EGF play an important role in initiating RPE cell migration. Basic FGF, PDGF, aFGF, and EGF stimulate RPE cell DNA synthesis.
System Life Expectancy and the Maintenance Effort: Exploring Their Equilibration1 (2000)

Aging information systems are expensive to maintain and most are eventually retired and replaced. But what determines (in the choices made by managers) whether and when a system reaches end-of-life? What shapes managers’ judgements about a system’s remaining life expectancy and do these judgments influence the maintenance effort itself? System maintenance and prospective replacement are examined here in new terms, positing that managers “equilibrate” (balance) their allocation of maintenance effort with their expectations of a system’s remaining life. Drawing from data on 758 systems among 54 organizations, support is found for an exploratory structural equation model in which the relationship between maintenance effort and remaining life expectancy is newly explained. A “portfolio effect,” reflecting a system’s familial complexity, is also found to be directly and positively related to the maintenance effort. A further finding is that a system’s size is directly and positively associated with its remaining life expectancy. Notwithstanding normative research suggesting the contrary, larger systems may tend to be longer-lived than smaller systems. Practically, the suggestion is made that better documented and monitored portfolios, together with regular, periodic performance assessments, can lead to better management of systems’ life cycles.
Distributed Service-Based Approach for Sensor Data Fusion in IoT Environments (2014)

The Internet of Things (IoT) enables the communication among smart objects promoting the pervasive presence around us of a variety of things or objects that are able to interact and cooperate jointly to reach common goals. IoT objects can obtain data from their context, such as the home, office, industry or body. These data can be combined to obtain new and more complex information applying data fusion processes. However, to apply data fusion algorithms in IoT environments, the full system must deal with distributed nodes, decentralized communication and support scalability and nodes dynamicity, among others restrictions. In this paper, a novel method to manage data acquisition and fusion based on a distributed service composition model is presented, improving the data treatment in IoT pervasive environments.
RIOT: I/O-Efficient Numerical Computing without SQL (2009)

R is a numerical computing environment that is widely popular for statistical data analysis. Like many such environments, R performs poorly for large datasets whose sizes exceed that of physical memory. We present our vision of RIOT (R with I/O Transparency), a system that makes R programs I/O-efficient in a way transparent to the users. We describe our experience with RIOT-DB, an initial prototype that uses a relational database system as a backend. Despite the overhead and inadequacy of generic database systems in handling array data and numerical computation, RIOT-DB significantly outperforms R in many large-data scenarios, thanks to a suite of high-level, inter-operation optimizations that integrate seamlessly into R. While many techniques in RIOT are inspired by databases (and, for RIOT-DB, realized by a database system), RIOT users are insulated from anything database related. Compared with previous approaches that require users to learn new languages and rewrite their programs to interface with a database, RIOT will, we believe, be easier to adopt by the majority of the R users.
Nucleotide sequence of chicken dystrophin cDNA (1988)

Journal Article Nucleotide sequence of chicken dystrophin cDNA Get access C. Lemaire, C. Lemaire Unité INSERM 184, LGME du CNRS, Faculté Médecine11 rue Humann, 67085 Strasbourg, France Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Heilig, R. Heilig Unité INSERM 184, LGME du CNRS, Faculté Médecine11 rue Humann, 67085 Strasbourg, France Search for other works by this author on: Oxford Academic PubMed Google Scholar J.L. Mandel J.L. Mandel Unité INSERM 184, LGME du CNRS, Faculté Médecine11 rue Humann, 67085 Strasbourg, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 24, 23 December 1988, Pages 11815–11816, https://doi.org/10.1093/nar/16.24.11815 Published: 23 December 1988 Article history Accepted: 21 November 1988 Published: 23 December 1988
Analogy Estimation Based on Particle Swarm Optimization and Bootstrap Inference for Software Effort (2010)

Wide attention has been attracted on software effort estimation by both software industry and academic community owing to its high ability in controlling software schedule,reducing software risk and guaranteeing software quality.This paper investigates the improvement effects of estimation accuracy in analogy-based model when particle swarm optimization method is adopted to optimize the feature weights.Meanwhile,nonparametric bootstrap was employed to generate samples for calibrating the number of the most similar projects and the project adaptation in PSO analogy model.Reliability of estimated value and confidence interval were calculated by nonparametric bootstrap too.Experiments were carried out using software projects from Desharnais dataset in order to verify the effectiveness of PSO analogy model and bootstrap inference method.Estimation accuracy of the PSO analogy model was compared with ordinary Analogy,SVR,ANN,RBF and CART in terms of the error measure which is MMRE and Pred(0.25).The empirical results show that applying particle swarm optimization method to optimize the feature weights is a feasible approach to improve the accuracy of software effort estimation.Moreover,nonparametric bootstrap can calibrate the variables in PSO analogy model and calculate estimation accuracy and confidence interval effectively.Results of the proposed model are beneficial to assess estimation accuracy,analyze risk and plan project.
Integral field unit for the echellette spectrograph and imager at Keck II (2003)

We present the design and status report on the development of an Integral Field Unit (IFU) for the Echellette spectrograph and imager (ESI), a recently developed R=13000, Cassegrain spectrograph at Keck II. We have designed a family of IFU’s for the spectrograph, providing a range of field-coverages and dispersions. The optical designs are based on the Advanced Image Slicer concept of Content. We describe the completely monolithic, passive, and modular implementation of this design as an IFU head. Each IFU head resides in an ESI slit mask holder, so that it is completely selectable/deselectable as an observing mode during a nights observing run.
Luciferase Fragment Complementation Imaging of Conformational Changes in the Epidermal Growth Factor Receptor (2009)

Crystal structures of the epidermal growth factor (EGF) receptor suggest that its activation is associated with extensive conformational changes in both the extracellular and intracellular domains. However, evidence of these structural dynamics in intact cells has been lacking. Here we use luciferase complementation imaging to follow EGF-induced conformational changes in its receptor in real time in live cells. When the luciferase fragments are fused to the C terminus of an EGF receptor lacking the cytoplasmic domain, EGF stimulates a rapid increase in luciferase activity, consistent with ligand-induced receptor dimerization. However, when the luciferase fragments are fused to the C terminus of the full-length receptor, EGF induces a rapid but transient decrease in luciferase activity. The decrease requires tyrosine kinase activity, whereas the subsequent recovery requires MAP kinase activity. Our data demonstrate the utility of the luciferase system for in vivo imaging changes in EGF receptor dimerization and conformation. They also identify two sequential ligand-induced conformational changes in the EGF receptor.
<i>W-sash</i> affects positive and negative elements controlling c-<i>kit</i> expression: ectopic c-<i>kit</i> expression at sites of kit-ligand expression affects melanogenesis (1993)

ABSTRACT The receptor tyrosine kinase c-kit and its cognate ligand KL are encoded at the white spotting (W) and steel (Sl) loci of the mouse, respectively. Mutations at both the W and the Sl locus cause deficiencies in gametogenesis, melanogenesis and hematopoiesis (erythrocytes and mast cells). The W-sash mutation differs from most W mutations in that it affects primarily mast cells and melanogenesis but not other cellular targets of W and Sl mutations. Thus, Wsh/Wsh mice are fertile and not anemic, but they lack mast cells in their skin and intestine and are devoid of coat pigment. Heterozygotes are black with a broad white sash/belt in the lumbar region. In order to determine the basis for the phenotypes of W-sash mice, we investigated c-kit RNA and protein expression patterns in adult Wsh/Wsh mice and during embryonic development. We show that c-kit expression is absent in bone-marrow-derived Wsh/Wsh mast cells, the fetal and the adult lung, and the digestive tract at embryonic day , tissues that normally express c-kit. Unexpectedly, in and Wsh/Wsh embryos, we found c-kit expression in the dermatome of the somites, the mesenchyme around the otic vesicle and the floorplate of the neural tube, structures known to express the c-kit ligand in wild-type embryos. The ectopic c-kit expression in Wsh homozygous embryos does not affect c-kit ligand expression. The presumed Wsh/Wsh melanoblasts appeared to be normal and, at similar numbers were found in normal and homozygous mutant embryos. At embryos had a graded distribution of melanoblasts from cranial to caudal with a minimum in the lumbar region. Whereas homozygous Wsh/Wsh embryos essentially lacked c-kit-positive cells in the skin, heterozygous Wsh/+ embryos had reduced numbers of melanoblasts compared to +/+ with few or none in the lumbar region (future sash). It is proposed that ectopic c-kit expression in the somitic dermatome affects early melanogensis in a dominant fashion. Molecular analysis of Wsh chromosomal DNA revealed a deletion or rearrangement in the vicinity of the c-kit gene. These results provide an explanation for the Wsh phenotype and have implications for the control of c-kit expression.
The history of external ventricular drainage (2013)

External ventricular drainage (EVD) is one of the most commonly performed neurosurgical procedures. It was first performed as early as 1744 by Claude-Nicholas Le Cat. Since then, there have been numerous changes in technique, materials used, indications for the procedure, and safety. The history of EVD is best appreciated in 4 eras of progress: development of the technique (1850-1908), technological advancements (1927-1950), expansion of indications (1960-1995), and accuracy, training, and infection control (1995-present). While EVD was first attempted in the 18th century, it was not until 1890 that the first thorough report of EVD technique and outcomes was published by William Williams Keen. He was followed by H. Tillmanns, who described the technique that would be used for many years. Following this, many improvements were made to the EVD apparatus itself, including the addition of manometry by Adson and Lillie in 1927, and continued experimentation in cannulation/drainage materials. Technological advancements allowed a great expansion of indications for EVD, sparked by Nils Lundberg, who published a thorough analysis of the use of intracranial pressure (ICP) monitoring in patients with brain tumors in 1960. This led to the application of EVD and ICP monitoring in subarachnoid hemorrhage, Reye syndrome, and traumatic brain injury. Recent research in EVD has focused on improving the overall safety of the procedure, which has included the development of guidance-based systems, virtual reality simulators for trainees, and antibiotic-impregnated catheters.