gebhart/patrepeval huggingface dataset:
Reversible and irreversible monoamine oxidase inhibitors in other psychiatric disorders (1990)

In addition to being effective in depressive disorders, monoamine oxidase inhibitors (MAOIs) have been shown to be effective in controlled studies of patient with panic disorder with agoraphobia, social phobia, atypical depression or mixed anxiety and depression, bulimia, posttraumatic stress disorder (PTSD) and borderline personality disorder. Uncontrolled case reports have noted MAOI efficacy in obsessive-compulsive disorder (OCD), trichotillomania, dysmorphophobia and avoidant personality disorder. Reversible inhibitors of MAO-A (RIMAs) appear safer than the classical irreversible MAOIs since they have less potential to increase blood pressure. They have not been studied as yet, however, in most of the conditions responsive to MAOIs. If RIMAs are found effective in these disorders, they would probably achieve wider use than MAOIs because they are safer and tend to cause fewer side effects.
Metathesis of Functionalized Alkenes. Synthesis of Insect Pheromones (1988)

The ability of substituted phenoxy complexes of tungsten to effect metathesis of both functionalized and non-functionalized terminal alkenes has been investigated. This methodology has been applied to the synthesis of the insect pheromones tetradec-9-en-1-yl acetate, dodec-7- en-1-yl acetate and tricos-9-ene.
Retinal Function and Morphology in the Rabbit Eye after Intravitreal Injection of the TNF Alpha Inhibitor Adalimumab (2014)

Injection of adalimumab into the vitreous body of healthy rabbits, at doses up to 2.5 mg, does not appear to be toxic to the rabbit retina.
Synthetic Studies of Cobalt Carbonyl by Noble Metal Catalysts. I. The Effects of the Form of Cobalt Feed and Noble Metal Catalysts (1969)

Abstract A novel method of synthesizing cobalt carbonyl was investigated by using noble metal catalysts. It has been observed that the materials containing palladium, i. e., palladium black, palladium chloride, palladium acetylacetonate, bistriphenylphosphine dichloropalladium, and palladium-on-carriers, have a catalytic effect on the cobalt carbonylation reaction, and that palladium-on-carbon (Pd-C) is the most active catalyst. The reactivity of cobalt compounds in the cobalt carbonylation reaction catalyzed by noble metals increases in this order: CoSO4&lt;&lt;CoO\lesssimCo(OAc)2\lesssimCo-oleate&lt;Co(OH)2. When the Pd-C catalyst is used, cobalt hydroxide reacts with synthesis gas of 150 kg/cm2 to give cobalt carbonyl almost quantitatively, even at from 50 to 55°C. The catalytic activities of noble metals were shown to be, in the order of decreasing activity: Pd&gt;Au&gt;Pt&gt;&gt;Ag. The effect of the catalyst concentration and the activity of noble-metal catalysts were also compared with those in the case of dicobalt octacarbonyl, as an autocatalyst.
Semantic locality and context-based prefetching using reinforcement learning (2015)

Most modern memory prefetchers rely on spatio-temporal locality to predict the memory addresses likely to be accessed by a program in the near future. Emerging workloads, however, make increasing use of irregular data structures, and thus exhibit a lower degree of spatial locality. This makes them less amenable to spatio-temporal prefetchers.
Constitutive expression of the cold-regulated <i>Arabidopsis thaliana COR15a</i> gene affects both chloroplast and protoplast freezing tolerance (1996)

Cold acclimation in plants is associated with the expression of COR (cold-regulated) genes that encode polypeptides of unknown function. It has been widely speculated that products of these genes might have roles in freezing tolerance. Here we provide direct evidence in support of this hypothesis. We show that constitutive expression of COR15a, a cold-regulated gene of Arabidopsis thaliana that encodes a chloroplast-targeted polypeptide, enhances the in vivo freezing tolerance of chloroplasts in nonacclimated plants by almost 2 degrees C, nearly one-third of the increase that occurs upon cold acclimation of wild-type plants. Significantly, constitutive expression of COR15a also affects the in vitro freezing tolerance of protoplasts. At temperatures between -5 and -8 degrees C, the survival of protoplasts isolated from leaves of nonacclimated transgenic plants expressing COR15a was greater than that of protoplasts isolated from leaves of nonacclimated wild-type plants. At temperatures between -2 and -4 degrees C, constitutive expression of COR15a had a slight negative effect on survival. The implications of these data regarding possible modes of COR15a action are discussed.
A C-based RTL design verification methodology for complex microprocessor (1997)

As the complexity of high-performance microprocessor increases,functional verification becomes more and more difficultand RTL simulation emerges as the bottleneck of thedesign cycle.In this paper, we suggest C language-based designand verification methodology to enhance the simulationspeed instead of the conventional HDL-based methodologies.RTL C model (StreC) describes the cycle-based behaviors ofsynchronous circuits and is followed by model refining andoptimization using LifeTime Analyzer (LTA) and Cleaner.The simulation speed of cycle-based C model makes it possibleto test the RTL design with the "real-world" applicationprograms in the order-of-magnitude faster speed thanthe commercial event-driven simulators.Using the proposedfunctional verification methodology, HK486, an intel 80486 - compatiblemicroprocessor was successfully designed and verified.
Moral conflict for the film librarian (2002)

The goal is to understand the basis of the moral dilemma for the film librarian (conflict between maintaining the collection's balance of perspectives and adhering only to the parent company's often singular point of view) and to attempt to resolve dilemma. An effort will be made to briefly compare Merleau-Ponty's theroy to other theoretical approaches. The essay will conclude by suggesting the following ways to avoid the dilemma of balance versus company loyalty: 1) film librarians should promote niche marketing to counterbalance the popular mass marketing to ensure the continued production of a variety of films; 2) the National Endowment for the Arts should fund a variety of films and filmmakers; and 3) government agencies should play a role in regulating the concentration of control in a wide variety of industries
All-Fiber Acousto-Optic Phase Modulators Using Zinc Oxide Films on Glass Fiber (1988)

This project is directed at developing high frequency phase modulators for use in all-fiber sensing and communication systems. These modulators are designed to be spliced directly into single mode fiber systems, as they are constructed with standard single mode glass fiber. They utilize the inherent acousto-optic effect in the glass. This is an alternative to the more usual approach to high frequency phase modulators using the electro-optic effect, which does not exist in glass fiber. This effect requires single crystal material, typically lithium niobate, on which devices are made using planar integrated optics waveguides.
Fast reference frame selection method for motion estimation in JVT/H.264 (2004)

The three main reasons why the new H.264 (MPEG-4 AVC) video coding standard has a significant performance better than the other standards are the adoption of variable block sizes, multiple reference frames, and the consideration of rate distortion optimization within the codec. However, these features incur a considerable increase in encoder complexity. As for the multiple reference frames motion estimation, the increased computation is in proportion to the number of searched reference frames. In this paper, a fast multi-frame selection method is proposed for H.264 video coding. The proposed scheme can efficiently determine the best reference frame from the allowed five reference frames. Simulation results show that the speed of the proposed method is over two times faster than that of the original scheme adopted in JVT reference software JM73 while keeping the similar video quality and bit-rate.
Clinical Application of Oligonucleotide Probe Array for Full-Length Gene Sequencing of <i>TP53</i> in Colon Cancer (2002)

The GeneChip p53 assay is sufficiently sensitive to detect TP53 mutations in surgical specimens from colon cancers and may be applicable to screening examination in clinical laboratories as a routine procedure.
The Role of the MAP Kinase Pathway in Breast Cancer. (1995)

Abstract : Growth factors may play an important role in the pathogenesis of breast cancer. The MAP kinase pathway may be essential for transformation caused growth factors. Thus, the purpose of this study is to determine if MAP kinases may be overexpressed or activated in breast cancer. About one-third of the breast cancer cell lines tested contained changes in the amounts of MAP kinases, although there was not one consistent pattern of alteration from the normal expression. An alteration in amount of any of the enzymes may be an indication of altered regulation of the pathway in the affected cells. Future experiments to further address this issue will focus on analyzing activation state and correlating changes in amounts of MAP kinases with stage of tumor. Newly available antibodies allow measurement of activated MAP kinases directly in cell lysates. These antibodies are being evaluated for use in immunocytochemistry of normal mammary epithelial cells and breast cancer cell lines. If these antibodies prove useful for immunocytochemistry, in the future tumors will be obtained from Dr. Gazdar of this institution so that activation state of MAP kinases can be measured in situ.
The effects of weak magnetic fields on radical pairs (2014)

It is proposed that radical concentrations can be modified by combinations of weak, steady and alternating magnetic fields that modify the population distribution of the nuclear and electronic spin state, the energy levels and the alignment of the magnetic moments of the components of the radical pairs. In low external magnetic fields, the electronic and nuclear angular momentum vectors are coupled by internal forces that outweigh the external fields' interactions and are characterized in the Hamiltonian by the total quantum number F. Radical pairs form with their unpaired electrons in singlet (S) or triplet (T) states with respect to each other. At frequencies corresponding to the energy separation between the various states in the external magnetic fields, transitions can occur that change the populations of both electron and nuclear states. In addition, the coupling between the nuclei, nuclei and electrons, and Zeeman shifts in the electron and nuclear energy levels can lead to transitions with resonances spanning frequencies from a few Hertz into the megahertz region. For nuclear energy levels with narrow absorption line widths, this can lead to amplitude and frequency windows. Changes in the pair recombination rates can change radical concentrations and modify biological processes. The overall conclusion is that the application of magnetic fields at frequencies ranging from a few Hertz to microwaves at the absorption frequencies observed in electron and nuclear resonance spectroscopy for radicals can lead to changes in free radical concentrations and have the potential to lead to biologically significant changes.
Comparison of liver progenitor cells in human atypical ductular reactions with those seen in experimental models of liver injury (1998)

The ultrastructural characteristics of liver progenitor cell types of human atypical ductular reactions seen in chronic cholestasis, in regenerating human liver after submassive necrosis, in alcoholic liver disease, and in focal nodular hyperplasia are compared with liver progenitor cell types seen during experimental cholangiocarcinogenesis in hamsters; during hepatocarcinogenesis in rats; and in response to periportal liver injury induced by allyl alcohol in rats. Three types of progenitor cells have been identified in human atypical ductular reactions: type I: primitive, has an oval shape, marginal chromatin, few cellular organelles, rare tonofilaments, and forms desmosomal junctions with adjacent liver cells; type II: bile duct-like, is located within ducts, has few organelles, and forms lateral membrane interdigitations with other duct-like cells; and type III: hepatocyte-like, is located in hepatic cords, forms a bile canaliculus, has tight junctions with other hepatocyte-like cells, prominent mitochondria and rough endoplasmic reticulum, and some have lysosomes and a poorly developed Golgi apparatus. Each type is seen during cholangiocarcinogenesis in hamsters, but the most prominent cell type is type II, duct-like. A more primitive cell type ("type 0 cell"), as well as type I cells, are seen in the intraportal zone of the liver within 1 to 2 days after carcinogen exposure or periportal injury in the rat, but both type II and type III are seen later as the progenitor cells expand into the liver lobule. After allyl alcohol injury, type 0 cells precede the appearance of type I and type III cells, but most of the cells that span the periportal necrotic zone are type III hepatocyte-like cells showing different degrees of hepatocytic differentiation. Some type II cells are also seen, but these are essentially limited to ducts. It is concluded that there is a primitive stem cell type in the liver (type 0) that may differentiate directly into type I and then into type II, duct-like or or type III hepatocyte-like cells. The terms oval cell, transitional hepatocyte, biliary hepatocyte, hepatocyte-like cell, atypical ductular cell, neocholangiole, etc., are used to describe these cells. Although these terms are useful as general descriptive terms for liver precursor cells at the light microscopic level, the cells included in these descriptive categories may be very different from one another biologically and ultrastructurally.
Synthesis of Imidazo[2, 1-a]phthalazines, Potential Inhibitors of p38 MAP Kinase. Prediction of Binding Affinities of Protein Ligands (2002)

Based upon molecular modeling, the pharmacophore of potential inhibitors of p38 MAPK (mitogen-activated protein kinases) is discussed and the predictive binding affinities are calculated. Syntheses of original diarylimidazo[2,1-a]phthalazines obtained by Suzuki coupling are described.
A CONFIGURABLE SECURED IMAGE ENCRYPTION TECHNIQUE USING 3D ARRAY BLOCK ROTATION (2012)

Security of the information was the exclusive domain of the multimedia applications and transfer of the data over the insecure mode of communication. A few years after the necessity of information security was invented researchers became aware of encryption/decryption techniques development by various agencies.In this paper a new technique of enciphering data which enables good diffusion for obscuring the redundancies in a plaintext messages. Image encryption is achieved using 3D array block rotation implementation.
A Recruitment and Human Resource Management Technique Using Blockchain Technology for Industry 4.0 (2018)

Application of Information Technology (IT) in the domain of Human Resource Management (HRM) systems is a sine qua non for any organization for successfully adopting and implementing Fourth Industrial Revolution (Industry 4.0). However, these systems are required to ensure non-biased, efficient, transparent and secure environment. Blockchain, a technology based on distributed digital ledgers, can help facilitate the process of successfully effectuating these specifications. A detailed literature review has been conducted to identify the current status of usage of Information Technology in the domain of Human Resource Management and how Blockchain can help achieve a smart, cost-effective, efficient, transparent and secure factory management system. A Blockchain based Recruitment Management System (BcRMS) as well as Blockchain based Human Resource Management System (BcHRMS) algorithm have been proposed. From the analysis of the results obtained through the case study, it is evident that the proposed system holds definite advantages compared to the existing recruitment systems. Future research directions have also been identified and advocated.
A role for metabolism in Rett syndrome pathogenesis (2013)

Rett syndrome (RTT), an X-linked neurological disorder caused by mutations in MECP2, may have a metabolic component. We reported a genetic suppressor screen in a Mecp2-null mouse model to identify pathways for therapeutic improvement of RTT symptoms. Of note, one suppressor mutation implied that cholesterol homeostasis was perturbed in Mecp2 null mice; indeed, cholesterol synthesis was elevated in the brain and body system. Remarkably, the genetic effect of downregulating the cholesterol pathway could be mimicked chemically by statin drugs, improving motor symptoms, and increasing longevity in the mouse. Our work linked cholesterol metabolism to RTT pathology for the first time. Both neurological and systemic effects of perturbed cholesterol homeostasis overlap with many RTT symptoms. Here we show in patients that peripheral cholesterol, triglycerides, and/or LDLs may be elevated early in RTT disease onset, providing a biomarker for patients that could be aided by therapeutic interventions that modulate lipid metabolism.
THE GENOME CONSTITUTIONS OF EASTERN NORTH AMERICAN <i>PHLOX</i> AMPHIPLOIDS (1968)

EvolutionVolume 22, Issue 3 p. 612-632 ArticleFree Access THE GENOME CONSTITUTIONS OF EASTERN NORTH AMERICAN PHLOX AMPHIPLOIDS Donald A. Levin, Donald A. Levin Department of Biological Sciences, University of Illinois at Chicago Circle, Chicago, IllinoisSearch for more papers by this author Donald A. Levin, Donald A. Levin Department of Biological Sciences, University of Illinois at Chicago Circle, Chicago, IllinoisSearch for more papers by this author First published: September 1968 https://doi.org/10.1111/j.1558-5646.1968.tb03996.xCitations: 19AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume22, Issue3September 1968Pages 612-632 ReferencesRelatedInformation
Total Synthesis of the Furaquinocins (1998)

A viable synthetic route to the furaquinocin-class antibiotics is described. The key steps include (1) Co-complex mediated stereospecific 1,2-shift of an alkynyl group (9 → 6) to establish the C(2)−C(3) stereochemical relationship, (2) efficient construction of furanonaphthalene 20 from the sodium carboxylate derived from ester 19, and (3) stereoselective methylene transfer reaction to aldehyde 21 to establish the three contiguous stereogenic centers, C(2), C(3), and C(10). The stereodefined epoxide 23, thus obtained, served as a versatile intermediate in divergent syntheses of four congeners of this class of natural products, furaquinocins A (1a), B (1b), D (1d), and H (1h), by changing the vinylic nucleophiles.
GeoCast---geographic addressing and routing (1997)

In the near future GPS will be widely used, thus al-lowing a broad variety of location dependent services such as direction giving, navigation, etc. In this pa-per we propose and evaluate a Touting and address-ing method to integrate geographic coordinates into the Internet Protocol to enable the creation of lo-cation dependent services. The main challenge is to integrate the concept of physical location into the current design of the Internet which relies on logical addressing. 1
Computing Camera Viewpoints in an Active Robot Work Cell (1999)

This paper presents a dynamic sensor-planning system that is capable of planning the locations and settings of vision sensors for use in an environment containing objects moving in known ways. The key component of this research is the computation of the camera position, orientation, and optical settings to be used over a time interval. A new algorithm is presented for viewpoint computation which ensures that the feature-detectability constraints of focus, resolution, field of view, and visibility are satisfied. A five-degree-of-freedom Cartesian robot carrying a CCD camera in a hand/eye configuration and surrounding the work cell of a Puma 560 robot was constructed for performing sensor-planning experiments. The results of these experiments, demonstrating the use of this system in a robot work cell, are presented.
Optimization of repeated‐batch transcription for RNA production (2000)

A major obstacle to large-scale RNA production is the high raw material cost. This work focuses on reducing the cost of RNA produced by in vitro transcription. RNA can be produced by transcription from DNA templates immobilized on solid supports such as agarose beads, with yields comparable to traditional solution-phase transcription. The advantage of immobilized DNA is that the templates can be recovered from the reaction and reused in multiple rounds, eliminating unnecessary disposal. Additionally, approximately 50% of the original RNA polymerase added to the reaction is also recovered in active form with the DNA and can be used for further rounds of repeated-batch transcription. Thus, adding only a fraction of the first-round enzyme concentration to subsequent rounds is sufficient for maintaining yields comparable to batch reactions for many rounds, with lowered cost. Results for two different DNA templates support a simplified model for repeated-batch transcription, based on the previous work of Davis and Breckenridge (J Biotechnol 1999;71:25–37). The model successfully predicts the yields for several of rounds of repeated-batch transcription using various enzyme addition schemes, and it was used to optimize the process by reducing the cost of raw materials per amount of RNA produced by 40–70%. © 2000 John Wiley & Sons, Inc. Biotechnol Bioeng 69: 679–687, 2000.
[Antithrombotic and antiplatelet effects of rosmarinic acid, a water-soluble component isolated from radix Salviae miltiorrhizae (danshen)]. (1993)

Wistar rats of both sex were used. Ros A was intravenously injected 5-10 min before blood collection or the ligation of vena cava. 1. Stasis-induced venous thrombosis: A tight ligature was applied to inferior vena cava below the left renal vein in anesthetized rats. The abdominal walls were closed and then reopened two hours later. The vena cava was clamped 2 cm below the ligature. This segment was cut to remove the thrombus. The dry weight of the thrombus was determined. 2. Platelet aggregation: Using Born's method the platelet aggregation induced by collagen or ADP was studied. 3. Blood coagulation times: Blood recalcium time (RT), kaolin partial thromboplastin time (KPTT) and prothrombin time (PT) were estimated. 4. Plasma fibrinolytic activity was observed by the determination of euglobulinolytic time (ELT). Plasma fibrinogen content was estimated based on the biuret reaction. The venous thrombosis was inhibited by 41.9% and 54.8% (P < 0.05) when Ros A was injected at the dosages of 50 and 100 mg/kg. The blood platelet aggregation elicited by collagen was suppressed by 30.4% (P < 0.05) and 46.4% (P < 0.01) after the injection of Ros A at doses of 100 and 150 mg/kg respectively. The ELT was shortened after the injection of Ros A (100 and 150 mg/kg) as compared with the control value (P < 0.05), while the plasma fibrinogen content remained unchanged. The results that Ros A showed mild antithrombotic effect. The mechanism of this effect might be related to its inhibition of platelet aggregation and promotion of fibrinolytic activity.