gebhart/patrepeval huggingface dataset:
Degree of branching of hyperbranched polystyrenes via a controlled radical mechanism of an inimer: Determination by a kinetic approach (2005)

Abstract We studied, with a kinetic approach, the living nature and degree of branching (DB) of the formation of hyperbranched polystyrene by the free‐radical photopolymerization of 2‐( N,N ‐diethyldithiocarbamyl)methylstyrene in benzene. The free‐radical polymerization proceeded with a living radical mechanism. Subsequently, we treated the kinetics of the initiation and propagation steps of the active A* and B* (side‐group) sites with model compounds. The degradation rates of two types of dithiocarbamate groups at the A and B sites agreed well with theoretical trends for CS bond dissociation energies predicted by the density functional theory for model compounds. The reactivity of the initiating B* groups was greater than that of the propagating A* groups. DB of the hyperbranched polymers was estimated to be 0.31 with both reaction rates in terms of Müller's equation. This result supported the DB value (0.39) estimated from NMR data. The hyperbranched molecules obtained in this work were not perfectly dendritic but had somewhat defective structures. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 1810–1815, 2005
Angiotensin II increases matrix metalloproteinase 2 expression in human aortic smooth muscle cells via AT1R and ERK1/2 (2015)

Increased levels of angiotensin II (Ang II) and activated matrix metalloproteinase 2 (MMP-2) produced by human aortic smooth muscle cells (human ASMCs) have recently been implicated in the pathogenesis of thoracic aortic aneurysm (TAA). Additionally, angiotensin II type 1 receptor (AT1R)-mediated extracellular signal-regulated kinase (ERK)1/2 activation contributes to TAA development in Marfan Syndrome. However, there is scant data regarding the relationship between Ang II and MMP-2 expression in human ASMCs. Therefore, we investigated the effect of Ang II on MMP-2 expression in human ASMCs and used Western blotting to identify the Ang II receptors and intracellular signaling pathways involved. Reverse transcription polymerase chain reaction (RT-PCR) and immunofluorescence data demonstrated that Ang II receptors were expressed on human ASMCs. Additionally, Ang II increased the expression of Ang II type 2 receptor (AT2R) but not AT1R at both the transcriptional and translational levels. Furthermore, Western blotting showed that Ang II increased MMP-2 expression in human ASMCs in a dose- and time-dependent manner. This response was completely inhibited by the AT1R inhibitor candesartan but not by the AT2R blocker PD123319. In addition, Ang II-induced upregulation of MMP-2 was mediated by the activation of ERK1/2, whereas p38 mitogen-activated protein kinase (p38 MAPK) and c-Jun N-terminal kinase (JNK) had no effect on this process. In conclusion, these results indicate that Ang II can increase the expression of MMP-2 via AT1 receptor and ERK1/2 signaling pathways in human ASMCs and suggest that antagonists of AT1R and ERK1/2 may be useful for treating TAAs.
Comparison of Baroreflex Sensitivity and Cardiac Autonomic Function Between Adolescent Athlete and Non-athlete Boys – A Cross-Sectional Study (2019)

<b>Introduction:</b> It is well known that regular physical activity improves cardiovascular health, and higher baroreflex sensitivity and heart rate variability are associated with cardiovascular health. Adolescence is the age when an individual's behavior is easily modified; early intervention at this stage in terms of physical conditioning or training prevents future cardiovascular risk. Hence, we conceived the present study to assess and compare the baroreflex sensitivity and autonomic function between adolescent athletes and non-athletes. <b>Methods:</b> We recruited school going athletes (<i>n</i> = 30) and non-athlete boys (<i>n</i> = 30) in the 10-19 age group after obtaining their assent and consent from their parents. We assessed height, weight, heart rate, blood pressure, baroreflex sensitivity, and cardiac autonomic function. Comparison between groups was made using the unpaired <i>t</i>-test for height, weight, body mass index, heart rate, blood pressure, and baroreflex sensitivity and using Mann-Whitney U test for cardiac autonomic function parameters. <b>Results:</b> There was a trend for higher baroreflex sensitivity in athletes. Heart rate variability (total power and SDNN) was higher in athletes. The parasympathetic tone was higher in terms of higher RMSSD, and higher HF power. Parasympathetic reactivity was higher in athletes in terms of higher 30:15 ratio and EI ratio. <b>Conclusion:</b> Athletic level physical conditioning has a positive influence on baroreflex function and autonomic function that may prove beneficial to the adolescents' cardiovascular health.
Acylation of alkenes generated in situ by hydride transfer from isoalkanes. Synthesis of pentalenones, hydrindenones, and cyclopentenones (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcylation of alkenes generated in situ by hydride transfer from isoalkanes. Synthesis of pentalenones, hydrindenones, and cyclopentenonesChristophe Morel-Fourrier, Jean Pierre Dulcere, and Maurice SantelliCite this: J. Am. Chem. Soc. 1991, 113, 21, 8062–8069Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/ja00021a036https://doi.org/10.1021/ja00021a036research-articleACS PublicationsRequest reuse permissionsArticle Views889Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pharmacokinetics of ciprofloxacin in pediatric cystic fibrosis patients (1996)

The pharmacokinetic characteristics of ciprofloxacin were studied in 10 children with cystic fibrosis, aged from 6 to 16 years, who had completed the standard regimen of intravenous ceftazidime and amikacin. The aim of the investigation was to derive dosing guidelines for young cystic fibrosis patients to be treated with ciprofloxacin. Each child received ciprofloxacin given as two 30-min infusions (10 mg/kg of body weight each) 12 h apart; this was followed by the administration of oral ciprofloxacin (15 mg/kg every 12 h). Blood samples were taken after both infusions and after the first oral dose. A total of 232 ciprofloxacin concentrations (203 concentrations in plasma and 29 concentrations in urine) were analyzed by use of NONMEM and a two-compartment body model with seven parameters: total body clearance (CL), volume of the central compartment (V2), volume of the peripheral compartment (V3), intercompartmental clearance, renal clearance, absorption rate constant, and bioavailability. The influences of weight (range, 18 to 42 kg) and age (range, 6 to 16 years) were investigated. CL (in liters per hour) was found to be linearly correlated with weight (typical value of CL = 8.8 + 0.396. WT, where WT is weight; (interindividual coefficient of variation, 7.8%). V2 and V3 were directly proportional to weight, with slopes of 0.7 and 1.3 liters/kg, respectively. Interindividual variabilities were calculated to be 22.6 and 14.9% for V2 and V3, respectively. No dependency of the other pharmacokinetic parameters on age or weight was seen. Because of the high correlations between age and weight, only one covariable was necessary. Weight had the strongest effect. Bioavailability (population mean) was estimated to be 61.8%, and renal clearance (population mean) was estimated to be 11.4 liters/h. The residual (intraindividual) variability was 31.9%. The protein binding was about 34%, which is similar to the results obtained for adults. In order to define the appropriate dosage regimen for children suffering from cystic fibrosis, a formula was derived so that steady-state concentrations, similar to those obtained in adults after the administration of dosages of 400 mg three times daily intravenously and 750 mg twice daily orally, could be reached. The calculated total daily dose increased with increasing body weight. Given as milligrams per kilogram of body weight, the calculated dosage regimens suggest that for younger children (weight range, 14 to 28 kg), 28 to 20 mg/kg orally twice daily should be given, and for older children (weight range, 28 to 42 kg), 20 to 15 mg/kg orally twice daily should be given. For intravenous administration, dosages of 15 to 10 mg/kg twice daily are sufficient.
A System for automatic weight determination of individual grain kernels: Principles and evaluation (1974)

Our objective was to develop an automatic system for weighing individual kernel of grain. The system is controlled by a minicomputer which counts the kernels and calculates the welght distribution...
Genomic Diversity in<i>Campylobacter jejuni</i>: Identification of<i>C. jejuni</i>81-176-Specific Genes (2005)

Since the publication of the complete genomic sequence of Campylobacter jejuni NCTC 11168 in February 2000, evidence has been compiling that suggests C. jejuni strains exhibit high genomic diversity. In order to investigate this diversity, the unique genomic DNA sequences from a nonsequenced Campylobacter strain, C. jejuni 81-176, were identified by comparison with C. jejuni NCTC 11168 by using a shotgun DNA microarray approach. Up to 63 kb of new chromosomal DNA sequences unique to this pathogen were obtained. Eighty-six open reading frames were identified by the presence of uninterrupted coding regions encoding a minimum of 40 amino acids. In addition, this study shows that the whole-plasmid shotgun microarray approach is effective and provides a comprehensive coverage of DNA regions that differ between two closely related genomes. The two plasmids harbored by this Campylobacter strain, pTet and pVir, were also sequenced, with coverages of 2.5- and 2.9-fold, respectively, representing 72 and 92% of their complete nucleotide sequences. The unique chromosomal genes encode proteins involved in capsule and lipooligosaccharide biosynthesis, restriction and modification systems, and respiratory metabolism. Several of these unique genes are likely associated with C. jejuni 81-176 fitness and virulence. Interestingly, the comparison of C. jejuni 81-176 unique genes with those of C. jejuni ATCC 43431 revealed a single gene which encodes a probable TraG-like protein. The product of this gene might be associated with the mechanism of C. jejuni invasion into epithelial cells. In conclusion, this study extends the repertoire of C. jejuni genes and thus will permit the construction of a composite and more comprehensive microarray of C. jejuni.
Design of Compact Air-Vias-Perforated SIW Horn Antenna With Partially Detached Broad Walls (2016)

A novel substrate-integrated waveguide (SIW) horn antenna with partially detached broad walls is designed and analyzed. The conventional SIW horn antenna suffers from narrow-operating bandwidth, which mainly results from the mismatch at the horn aperture between the substrate and the free space. However, the detachment of the broad walls makes the left substrate not only act as wave-guiding structure but also impedance transformer, which brings much size reduction in comparison with conventional SIW horn antenna. Moreover, the substrate with graded dielectric constants distributed in the propagating direction is realized through perforating air-vias with different diameters to further improve the radiation performance. Results indicate that the proposed antenna operates from 17.7 to 26.7 GHz with a nearly constant peak-radiating gain between 8 and 9 dBi at end-fire direction. Stable end-fire radiation patterns can be realized in the whole operating band. Above all, the proposed technology makes it compact to design SIW horn antenna of high performance without extra extension after the aperture of the radiating horn.
Postmodernists, Marxists and the poor science in the modernity (2013)

Based on the discussions about modernity, rationality and science, this article intends to broach the debate, within the field of Social Sciences, among postmodernists and Marxists about the validity of modern science and the criterion to determinate, or not, a new historical stage. To situate this debate, we sought an analysis of the Michel Meffesoli’s postmodern thought and the Marxist critique of Ellen Wood Meiksins. As a result, this article intends to clarify key points of the theoretical debate and present a critical analysis about the validity, and the problems, of Marxist and post-modern’s approaches.
Peripheral kappa‐opioid agonists for visceral pain (2004)

Kappa (kappa)-opioid receptor agonists are particularly effective analgesics in experimental models of visceral pain. Their analgesic effects are mediated in the periphery. The molecular targets involved include peripherally located kappa-receptors and possibly, at least for some nonpeptidic kappa-agonists, additional nonopioid molecular targets such as sodium channels located on primary sensory afferents. Overall, these properties are expected to be of therapeutic interest in various visceral pain conditions, including abdominal surgery associated with postoperative pain and ileus, pancreatitis pain, dysmenorrhea, labor pain and functional disorders such as irritable bowel syndrome or dyspepsia. The first kappa-agonists to be developed were brain-penetrating organic small molecules. Their development was eventually discontinued due to central side effects such as sedation and dysphoria attributed to kappa-receptors located behind the blood-brain barrier. New drug discovery programs are now geared towards the design of peripherally-selective kappa-agonists. So far, most of the organic molecule-based peripheral kappa-agonists have achieved limited peripheral selectivity and a practically insufficient therapeutic window to justify full development. These compounds have been used in a small number of clinical pilot studies involving visceral pain. Although encouraging, the clinical data available so far with this class of compounds are too limited and fragmented to fully validate the therapeutic utility of kappa-agonists in visceral pain. Additional clinical studies with safer kappa-agonists (i.e. with higher peripheral selectivity) are still required. The most suitable tools to address this question in the future appear to be the newly discovered class of tetrapeptide-based kappa-agonists, which have shown unprecedented levels of peripheral selectivity.
Engine flame imaging using electrical capacitancetomography (1994)

First results of engine flame imaging using electrical capacitance tomography (ECT) are described. A six-electrode capacitance sensor fabricated as part of a research engine provides 15 capacitance measurements per scan. A transputer-based ECT system is used to reconstruct the cross-sectional images of flames in the engine from successive sets of capacitance measurements. The prototype system is capable of capturing flame images at 315 frames per second and has potential for monitoring engine performance.
DETERMINATION OF DIFFUSIVITY AND HYDRAULIC CONDUCTIVITY IN SOILS AT LOW WATER CONTENTS FROM NONDESTRUCTIVE TRANSIENT FLOW OBSERVATIONS (1986)

We present an experimental method that nondestructively, relatively quickly, and reproducibly develops data necessary for finite-difference calculations of liquid-vapor diffusivities for water contents between approximately 1% and any intermediate value of interest. Diffusivity functions for five different soils, ranging in texture from fine sands to a clay loam, were determined. Vapor adsorption and transport mechanisms are discussed in the context of the liquid-vapor diffusivity function, using experimentally measured vapor adsorption isotherms. Conductivities calculated from results of experiments conducted using thermocouple psychrometers to nondestructively measure suction heads in a clay loam during the flow process are also presented.
Computer-Assisted Preoperative Planning for Reduction of Proximal Femoral Fracture Using 3-D-CT Data (2008)

This paper describes procedures for repositioning calculations of fractured bone fragments using 3-D-computed tomography (CT), aimed at preoperative planning for computer-guided fracture reduction of the proximal femur. Fracture boundaries of the bone fragments, as "fracture lines (FLs)," and the mirror-transformed contralateral femur shape extracted from 3-D-CT were used for repositioning of the fragments. We first describe a method for extracting FLs based on 3-D curvature analysis and then formulate repositioning methods based on registration of bone fragments using the following three constraints: 1) contralateral (CL) femur shape; 2) FLs; and 3) both CL femur shape and fracture lines, as "both constraints". We performed experiments using CT datasets from five simulated and four real patients with proximal femoral fracture. We evaluated the rotation error in reposition calculations and the contact ratio between repositioned fragment boundaries, which are crucial for the recovery of proper functional axes and bone adhesion of fragments, respectively. Experimental results showed that good accuracy and stability were attainable when registration using both constraints was performed after registration using the fracture-line constraint. On average, 6.0 degrees +/-0.8 degrees in rotation error and 89%+/-3 % in contact ratio were obtained without providing precise initial values.
Denaturing gradient gel electrophoresis analysis for the detection of point mutations in the Chlamydia trachomatis major outer-membrane protein gene (1995)

Fifty clinical strains of Chlamydia trachomatis were studied by denaturing gradient gel electrophoresis (DGGE) of bacterial DNA amplified by the polymerase chain reaction (PCR). The strains belonged to the three most commonly encountered serovars in developed countries--D, E and F. Six reference strains, including the serovar Da strain, were also studied. The DNA sequences explored encompassed the four variable domains (VDs) of omp1, the gene encoding the major outer-membrane protein (MOMP). The corresponding regions in the MOMP contain the species-, subspecies- and serovar-specific epitopes. The four distinct serovars were clearly differentiated by specific migration pattern. No sequence variations were observed among strains of serovar F. However, variant strains within serovars D and E were found, which exhibited migration patterns different from those of the reference strains and these were sequenced directly. According to the observed sequence variations, serovar D strains could be divided into three stable representative groups (D, D1 and D2). Two variants were identified among serovar E strains. No biological differences were observed for the variant strains in terms of growth properties, ecology or pathogenicity. All the nucleotide substitutions detected in the VDs were non-synonymous at the protein level and, for the serovar D strains, could account for differences identified by specific monoclonal antibodies. These substitutions could be involved in antigenic drift, driven by the immune pressure of the host, leading to the emergence of serovariants. The data may explain, in part, chlamydial infection recurrences and could have critical implications for developing rational vaccine strategies.
Efficient anomaly intrusion detection system in adhoc networks by mobile agents (2010)

Networks are protected using many firewalls and encryption software's. But many of them are not sufficient and effective. Most intrusion detection systems for mobile ad hoc networks are focusing on either routing protocols or its efficiency, but it fails to address the security issues. Some of the nodes may be selfish, for example, by not forwarding the packets to the destination, thereby saving the battery power. Some others may act malicious by launching security attacks like denial of service or hack the information. The ultimate goal of the security solutions for wireless networks is to provide security services, such as authentication, confidentiality, integrity, anonymity, and availability, to mobile users. This paper incorporates agents and data mining techniques to prevent anomaly intrusion in mobile adhoc networks. Innuendo, presenting an anomaly detection system comprises of detection modules for detecting anomalies in each layer. Home agents present in each system collects the data from its own system and using data mining techniques to observed the local anomalies. The Mobile agents monitoring the neighboring nodes and collect the information from neighboring home agents to determine the correlation among the observed anomalous patterns before it will send the data. This system was able to stop all of the successful attacks in an adhoc networks and reduce the false alarm positives.
Total synthesis of (.+-.)-ilicicolin H (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (.+-.)-ilicicolin HDavid R. Williams, Martin L. Bremmer, David L. Brown, and Joseph D'AntuonoCite this: J. Org. Chem. 1985, 50, 15, 2807–2809Publication Date (Print):July 1, 1985Publication History Published online1 May 2002Published inissue 1 July 1985https://pubs.acs.org/doi/10.1021/jo00215a053https://doi.org/10.1021/jo00215a053research-articleACS PublicationsRequest reuse permissionsArticle Views673Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts