gebhart/patrepeval huggingface dataset:
Polarized Distribution of Endogenous Rac1 and RhoA at the Cell Surface (1999)

Rac1 and RhoA regulate membrane ruffling and stress fiber formation. Both molecules appear to exert their control from the plasma membrane. In fibroblasts stimulated with platelet-derived growth factor or lysophosphatidic acid, the reorganization of the cytoskeleton begins at specific sites on the cell surface. We now report that endogenous Rac1 and RhoA also have a polarized distribution at the cell surface. Cell fractionation and immunogold labeling show that in quiescent fibroblasts both of these molecules are concentrated in caveolae, which are plasma membrane domains that are associated with actin-rich regions of the cell. Treatment of these cells with platelet-derived growth factor stimulated the recruitment of additional Rac1 and RhoA to caveolae fractions, while lysophosphatidic acid only caused the recruitment of RhoA. We could reconstitute the recruitment of RhoA using either whole cell lysates or purified caveolae. Surprisingly, pretreatment of the lysates with exoenzyme C3 shifted both resident and recruited RhoA from caveolae to noncaveolae membranes. The shift in location was not caused by inactivation of the RhoA effector domain. Moreover, chimeric proteins containing the C-terminal consensus site for Rac1 and RhoA prenylation were constitutively targeted to caveolae fractions. These results suggest that the polarized distribution of Rho family proteins at the cell surface involves an initial targeting of the protein to caveolae and a mechanism for retaining it at this site.
The Conversion of Codeinone to Codeine (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Conversion of Codeinone to CodeineMarshall GatesCite this: J. Am. Chem. Soc. 1953, 75, 17, 4340–4341Publication Date (Print):September 1, 1953Publication History Published online1 May 2002Published inissue 1 September 1953https://pubs.acs.org/doi/10.1021/ja01113a511https://doi.org/10.1021/ja01113a511research-articleACS PublicationsRequest reuse permissionsArticle Views474Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Overcoming Glitches and Dissipation Timing Skews in Design of DPA-Resistant Cryptographic Hardware (2007)

Cryptographic embedded systems are vulnerable to differential power analysis (DPA) attacks. This paper propose a logic design style, called as pre-charge masked Reed-Muller logic (PMRML) to overcome the glitch and dissipation timing skew (DTS) problems in design of DPA-resistant cryptographic hardware. Both problems can significantly reduce the DPA-resistance. To our knowledge, the DTS problem and its countermeasure have not been reported. The PMRML design can be fully realized using common CMOS standard cell libraries. Furthermore, it can be used to implement universal functions since any Boolean function can be represented as the Reed-Muller form. An AES encryption module was implemented with multi-stage PMRML. The results show the efficiency and effectiveness of the PMRML design methodology
Interleukin-13–induced MUC5AC Is Regulated by 15-Lipoxygenase 1 Pathway in Human Bronchial Epithelial Cells (2009)

Epithelial 15LO1 expression increases with increasing asthma severity. IL-13 induction of 15-HETE-PE enhances MUC5AC expression in human airway epithelial cells. High levels of 15LO1 activity could contribute to the increases of MUC5AC observed in asthma.
Size-Dependent Dissociation of Carbon Monoxide on Cobalt Nanoparticles (2013)

In situ soft X-ray absorption spectroscopy (XAS) was employed to study the adsorption and dissociation of carbon monoxide molecules on cobalt nanoparticles with sizes ranging from 4 to 15 nm. The majority of CO molecules adsorb molecularly on the surface of the nanoparticles, but some undergo dissociative adsorption, leading to oxide species on the surface of the nanoparticles. We found that the tendency of CO to undergo dissociation depends critically on the size of the Co nanoparticles. Indeed, CO molecules dissociate much more efficiently on the larger nanoparticles (15 nm) than on the smaller particles (4 nm). We further observed a strong increase in the dissociation rate of adsorbed CO upon exposure to hydrogen, clearly demonstrating that the CO dissociation on cobalt nanoparticles is assisted by hydrogen. Our results suggest that the ability of cobalt nanoparticles to dissociate hydrogen is the main parameter determining the reactivity of cobalt nanoparticles in Fischer-Tropsch synthesis.
Method of phase-dispersion introscopy (1997)

A method is described for studying the internal structure of noncrystalline objects which are weak x-ray absorbers. The method uses the conventional arrangement of plane-wave topography. The object to be investigated is immersed in a monochromatic pseudoplane wave formed by a highly asymmetric reflection off a perfect crystal or several crystals and introduces phase disruptions at the wave front. A perfect single crystal mounted behind the object in a Laue arrangement reveals these disturbances, forming a contrast image of the boundaries of the structural components of the object. The possibilities of the method are illustrated by photographs of objects of various natures. The features of the image contrasts are discussed and confirmed by experiments on test objects.
Rhizosphere Concentrations of Zinc and Cadmium in a Metal Contaminated Soil After Repeated Phytoextraction By<i>Sedum Plumbizincicola</i> (2011)

A growth chamber pot experiment and a field plot experiment were conducted with the installation of rhizobags to study the effects of repeated phytoextraction by Sedum plumbizincicola on the bioavailability of Cd and Zn in the rhizosphere and bulk soil Repeated phytoextraction gave significantly lower Cd and Zn concentrations in both rhizosphere and bulk soil solutions compared with soil without repeated phytoextraction. The depletion rates of NH40Ac-extractable Zn in rhizosphere soil in each treatment (L-PS, L-NPS, H-PS, and H-NPS) were 59.7, 18.0, 16.3, and 18.6%, respectively. For NH40Ac-extractable Cd, the depletion rates in treatments L-PS, L-NPS, H-PS, and H-NPS were 6.67, 29.4, 40.3, and 41.4%, respectively. Plant shoot biomass decreased in the order H-PS > H-NPS > L-PS > L-NPS, with dry weights of 0.56, 0.42, 1.43, and 1.21 g pot(-1), respectively. Plant Cd uptake increased with increasing aqua-regia extractable metal concentrations. The NH4OAc extraction procedure was satisfactory to predict the bioavailability of Cd and Zn in rhizosphere soil in terms of shoot uptake by S. plumbizincicola with positive correlation coefficients of 0.545 (p < 0.05) and 0.452 (p < 0.05), respectively. The field study results show a slight decrease in water soluble and NH4OAc-extractable metals, a trend similar to that found in the pot experiment.
Isolation of Specific Genomic Regions and Identification of Their Associated Molecules by Engineered DNA-Binding Molecule-Mediated Chromatin Immunoprecipitation (enChIP) Using the CRISPR System and TAL Proteins (2015)

Comprehensive understanding of genome functions requires identification of molecules (proteins, RNAs, genomic regions, etc.) bound to specific genomic regions of interest in vivo. To perform biochemical and molecular biological analysis of specific genomic regions, we developed engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP) to purify genomic regions of interest. In enChIP, specific genomic regions are tagged for biochemical purification using engineered DNA-binding molecules, such as transcription activator-like (TAL) proteins and a catalytically inactive form of the clustered regularly interspaced short palindromic repeats (CRISPR) system. enChIP is a comprehensive approach that emphasizes non-biased search using next-generation sequencing (NGS), microarrays, mass spectrometry (MS), and other methods. Moreover, this approach is not restricted to cultured cell lines and can be easily extended to organisms. In this review, we discuss applications of enChIP to elucidating the molecular mechanisms underlying genome functions.
Quantum Dots in Semiconductor Optoelectronic Devices (2006)

Nanoscale materials such as semiconductor quantum dots (SQDs) have electronic and optical properties between those of much larger macro and microscale bulk semiconductor crystals, and much smaller atoms and molecules.
Lipid peroxidation and glutathione levels after cortical injection of ferric chloride in rats: effect of trimetazidine and deferoxamine. (2000)

Intracortical injection of iron salts causes seizures. Oxidation of lipids in neural membranes by reactive oxygen species is involved in the mechanism responsible for iron-induced seizures as a model of posttraumatic epilepsy. In this study, we examined the effect of trimetazidine (TMZ) and deferoxamine (DFO) on lipid peroxidation after cortical injection of 5 microliters of an aqueous solution containing 100 mM of ferric chloride (FeCl3) in rats. Animals were divided into four groups (n = 7 each) and treated as follows: group 1, saline injection into the cortex (control group); group 2, iron injection into the cortex (injury group); group 3, iron injection into the cortex plus TMZ; group 4, iron injection into the cortex plus DFO. The animals were killed 3 h after injections, and the levels of malondialdehyde (MDA), a lipid peroxidation product, and reduced glutathione (GSH) were measured. A significant elevation of MDA was observed in group 2 (P < 0.05). MDA levels were found to be lower in both the TMZ-treated (P < 0.05) and DFO-treated (P < 0.05) groups than in the injury group. Tissue GSH levels were significantly decreased in group 2 (P < 0.05). GSH levels were increased in the TMZ-treated (P < 0.05) and DFO-treated (P < 0.05) groups compared to the injury group. The results of our study suggest that lipid peroxidation is a critical event in iron-induced epilepsy and that treatment with TMZ and DFO is effective in preventing the formation of free radicals and reducing lipoperoxides in brain tissue.
Use of Solvents To Improve the Productivity of Gas Condensate Wells (2000)

Abstract Experiments have been done with a retrograde gas condensate fluid to measure the decrease in gas relative permeability due to liquid dropout below the dew point and to evaluate the use of methanol to restore the gas relative permeability. The methanol was found to increase the end-point gas relative permeability by a factor of 1.2 to 2.5 depending on the initial water saturation. A likely reason for the increased gas permeability is the miscible displacement of the condensate and water phases by the methanol. The use of an inexpensive solvent such as methanol to improve the productivity of gas wells that have been damaged by production below the dew point due to condensate and/or water blocking presents an attractive approach deserving further investigation.
Heterogeneous Acid Hydrolysis of Native Cellulose Fibers (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHeterogeneous Acid Hydrolysis of Native Cellulose FibersE. A. Immergut and B. G. RånbyCite this: Ind. Eng. Chem. 1956, 48, 7, 1183–1189Publication Date (Print):July 1, 1956Publication History Published online1 May 2002Published inissue 1 July 1956https://pubs.acs.org/doi/10.1021/ie50559a027https://doi.org/10.1021/ie50559a027research-articleACS PublicationsRequest reuse permissionsArticle Views249Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A practical approach of memory access parallelization to exploit multiple off-chip DDR memories (2008)

3D stacked memory enables more off-chip DDR memories. Redesigning existing IPs to exploit the increased memory parallelism will be prohibitively costly. In our work, we propose a practical approach to exploit the increased bandwidth and reduced latency of multiple off-chip DDR memories while reusing existing IPs without modification. The proposed approach is based on two new concepts: transaction id renaming and distributed soft arbitration. We present two on-chip network components, request parallelizer and read data serializer, to realize the concepts. Experiments with synthetic test cases and an industrial strength DTV SoC design show that the proposed approach gives significant improvements in total execution cycle (21.6%) and average memory access latency (31.6%) in the DTV case with a small area overhead (30.1% in the on-chip network, and less than 1.4% in the entire chip).
Using Flow Electrodes in Multiple Reactors in Series for Continuous Energy Generation from Capacitive Mixing (2014)

Efficient conversion of “mixing energy” to electricity through capacitive mixing (CapMix) has been limited by low energy recoveries, low power densities, and noncontinuous energy production resulting from intermittent charging and discharging cycles. We show here that a CapMix system based on a four-reactor process with flow electrodes can generate constant and continuous energy, providing a more flexible platform for harvesting mixing energy. The power densities were dependent on the flow-electrode carbon loading, with 5.8 ± 0.2 mW m–2 continuously produced in the charging reactor and 3.3 ± 0.4 mW m–2 produced in the discharging reactor (9.2 ± 0.6 mW m–2 for the whole system) when the flow-electrode carbon loading was 15%. Additionally, when the flow-electrode electrolyte ion concentration increased from 10 to 20 g L–1, the total power density of the whole system (charging and discharging) increased to 50.9 ± 2.5 mW m–2.
95.29 The order of elements in SL (2, <i>p</i> ) (2011)

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An improved neural ensemble framework for accurate PV output power forecast (2016)

A significant role of renewable energy resource such as solar photovoltaic (PV) is substantially important for the smart grid. One of a major challenge for large scale integration of PV into the grid is intermittent and uncertain nature of solar PV. Therefore, developing a framework for accurate PV output power forecast is utmost important. In this research, a novel ensemble forecast framework is purposed. A novel feed forward neural network (FNN) ensemble based forecast framework is proposed and trained with particle swarm optimization (PSO). The wavelet transform (WT) technique is applied to handle the sharp spikes and fluctuations in historical PV output data. Correlated variables such as PV output power data, solar irradiance, temperature, humidity and wind speed are applied as inputs to forecast the PV output power precisely. The performance of proposed framework was analyzed for one day ahead load PV output power forecast of summer (S), autumn (A), winter (W) and spring (SP) days. The selected days from each season are a clear day (CD), partial cloudy day (PCD) and cloudy day (CLD). The proposed forecast framework provides higher forecast accuracy compared to persistence and backpropagation neural network (BPNN) model.
Transport of Na+ and HCO3- Out of Red Blood Cells Is Simultaneous with a Chloride Shift in Canine and Human Whole Blood Exposed to CO2-Rich Gas. (1993)

To study the release of Na+ from erythrocytes, arterial whole blood obtained from anesthetized and heparinized dogs (n = 8), or human (n = 9) venous blood was aerated with a CO2-rich gas mixture (15% CO2, 25% O2, 60% N2) at a rate of 1 l/min. To examine possible mechanisms involved in the release of sodium ions into plasma, CO2-rich gas was also passed through whole blood in the presence of acetazolamide (n = 8), SITS (n = 8), or furosemide (n = 8). The changes in blood gas parameters, plasma protein concentration, hematocrit, and plasma sodium, chloride, and bicarbonate ion concentrations were examined. When CO2-rich gas was passed through treated and untreated canine or human whole blood, PCO2 and plasma sodium and bicarbonate contents per ml of blood increased, while pH and plasma chloride content per ml of whole blood decreased. After 0 to 5 min of CO2-rich gassing, the mean rates of change in plasma ion contents per ml of whole blood per min were related by the following equations: (1) delta MCI- = a (delta MNa+), (2) delta MHCO3- = b(delta MNa+), (3) delta MHCO3- approximately equal to delta MNa+ + delta MCl-, (4) b approximately equal to 1 + a. These results suggest that the release of Na+ and HCO3- from erythrocytes into plasma in canine and human whole blood occurred in a one-to-one ratio simultaneously with, and probably independently of, the well-known chloride shift during a period of 0 to 5 min after the start of CO2-rich gassing.
Electron beam modeling and commissioning for Monte Carlo treatment planning (2000)

A hybrid approach for commissioning electron beam Monte Carlo treatment planning systems has been studied. The approach is based on the assumption that accelerators of the same type have very similar electron beam characteristics and the major difference comes from the on-site tuning of the electron incident energy at the exit window. For one type of accelerator, a reference machine can be selected and simulated with the Monte Carlo method. A multiple source model can be built on the full Monte Carlo simulation of the reference beam. When commissioning electron beams from other accelerators of the same type, the energy spectra in the source model are tuned to match the measured dose distributions. A Varian Clinac 2100C accelerator was chosen as the reference machine and a four-source beam model was established based on the Monte Carlo simulations. This simplified beam model can be used to generate Monte Carlo dose distributions accurately (within 2%/2 mm compared to those calculated with full phase space data) for electron beams from the reference machine with various nominal energies, applicator sizes, and SSDs. Three electron beams were commissioned by adjusting the energy spectra in the source model. The dose distributions calculated with the adjusted source model were compared with the dose distributions calculated using the phase space data for these beams. The agreement is within 1% in most of cases and 2% in all situations. This preliminary study has shown the capability of the commissioning approach for handling large variation in the electron incident energy. The possibility of making the approach more versatile is also discussed.
Controller for Urban Intersections Based on Wireless Communications and Fuzzy Logic (2009)

A major research topic in intelligent transportation systems (ITSs) is the development of systems that will be capable of controlling the flow of vehicular traffic through crossroads, particularly in urban environments. This could significantly reduce traffic jams, since autonomous vehicles would be capable of calculating the optimal speed to maximize the number of cars driving through the intersection. We describe the use of vehicle-to-vehicle (V2V) communications to determine the position and speed of the vehicles in an environment around a crossroad. These data are used to estimate the intersection point, and a fuzzy controller then modifies the speed of the cars without right of way according to the speed of the car with right of way. Experimental tests conducted with two mass-produced cars on a real circuit at the facilities of the Instituto de Automa¿tica Industrial, Consejo Superior de Investigaciones Cienti¿ficas, Madrid, Spain, gave excellent results.
Interworking internet telephony and wireless telecommunications networks (2001)

Internet telephony and mobile telephony are both growing very rapidly. Directly interworking the two presents significant advantages over connecting them through an intermediate PSTN link. We propose three novel schemes for the most complex aspect of the interworking: call delivery from an Internet telephony (SIP) terminal to a mobile telephony (UMTS) terminal. We then evaluate the proposals both qualitatively and quantitatively. However, existing equipment may not support packet interfaces needed for such interworking. Therefore, we also consider techniques for backward compatibility, and analyze their performance as well.
The Preparation of N-Dialkylphosphorylated Glycine (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of N-Dialkylphosphorylated GlycineT. Lies, R. E. Plapinger, and T. Wagner-JaureggCite this: J. Am. Chem. Soc. 1953, 75, 22, 5755–5756Publication Date (Print):November 1, 1953Publication History Published online1 May 2002Published inissue 1 November 1953https://doi.org/10.1021/ja01118a523RIGHTS & PERMISSIONSArticle Views61Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (313 KB) Get e-Alerts Get e-Alerts