gebhart/patrepeval huggingface dataset:
Java RMI: Remote Method Invocation (1998)

From the Publisher:
Building distributed applications in Java has never been easier. Java RMI: Remote Method Invocation is a new how-to guide that supplies you with all the information you need to create advanced network applications like databases, Chat servers, and more.

Java RMI: Remote Method Invocation is also the consummate reference for every Java programmer interested in RMI. This book offers a complete overview of Java RMI, including classes, interfaces, and RMI Name Service. And it provides in-depth explanations of advanced Java RMI concepts, real-world applications, and a quick reference for RMI packages and classes.

The CD-ROM features the Java Development Kit 1.1.4 as well as the source code for all the examples in this book.
Serum soluble transferrin receptor and the prediction of marrow aspirate iron results in a heterogeneous group of patients (1999)

Serum soluble transferrin receptor (sTfR) concentration has been evaluated in the diagnosis of iron deficiency in otherwise healthy individuals and in patients with rheumatoid arthritis, but has not been studied in a general population of patients with complicated clinical presentations. In this study, 145 anaemic patients with a variety of medical conditions undergoing diagnostic bone marrow aspiration for any reason were tested by a complete blood count, a panel of biochemical tests to evaluate iron status, bone-marrow aspirate iron stain, and serum sTfR concentration. Sixteen per cent lacked stainable iron in the marrow aspirate. All biochemical parameters differed significantly between patients with or without stainable marrow iron. The sTfR assay was significantly more sensitive but less specific than other iron status assays in identifying the absence of stainable iron. Logistic regression analysis demonstrated that only sTfR and ferritin contributed independently to the prediction of marrow iron status. Serum ferritin alone was highly specific but insensitive. A decision algorithm combining serum ferritin and sTfR was as sensitive as TfR and as specific as serum ferritin. The measurement of serum sTfR, especially in conjunction with serum ferritin, is a valuable addition to the existing methods for predicting the results of marrow aspirate iron stains.
Hg0.7Cd0.3Te charge-coupled device shift registers (1978)

Eight-bit CCD shift registers with 10-μm-long electrodes have been successfully fabricated on n-type Hg0.7Cd0.3Te and operated between temperaures of 77 and 140 K. At 77 K, a charge transfer efficiency of 0.996 was obtained under four-phase operation between 1 and 100 kHz clock frequencies. The input signal was provided by pulsing an input gate beyond the tunnel breakdown limit during the on-time of the phase-one potential well. Signal was detected using a floating-gate output followed by correlated double sampling. The size of the signal is in agreement with predictions.
Effects of Isoflavone Dietary Supplementation on Cardiovascular Risk Factors in Type 2 Diabetes (2007)

A diet supplemented with soy protein and isoflavones has been shown to reduce cardiovascular risk factors in postmenopausal women with type 2 diabetes. However, it remains unclear which component is responsible for these effects. Our aim was to determine whether the addition of isoflavones alone modifies cardiovascular disease risk markers in this group of patients. Cardiovascular disease (CVD) is the leading cause of mortality in women in developed countries (1), and women with diabetes are four times more likely to die from CVD than men (2). Among other factors, postmenopausal estrogen depletion, greater insulin resistance, and dyslipidemia (3,4) may contribute to high risk of accelerated CVD.

Modification of lifestyle is important to reduce CVD risk factors and delay progression of type 2 diabetes–associated complications. In particular, the addition of oral supplements, such as soy products, as part of a healthy diet has attracted recent interest because of their beneficial effects on lipid profiles (5–10). However, scant information is available on the effects of soy in individuals with type 2 diabetes (11–13), who are at higher risk due to hyperlipidemia, lower HDL levels, and abnormalities in LDL/lipoprotein composition (14). It also remains unclear whether a beneficial effect can be attributed to the soy protein or isoflavones. …
Oxidative Stress–Mediated Down–Regulation of Rat Hydroxyacid Oxidase 1, A Liver–Specific Peroxisomal Enzyme (2003)

Hydroxyacid oxidase 1 (Hao1) is a liver-specific peroxisomal enzyme that oxidizes glycolate to glyoxylate with concomitant production of H2O2. In Hao1 messenger RNA (mRNA), an iron-responsive element (IRE) homologous to the sequence recognized by iron regulatory proteins (IRP), key regulators of iron homeostasis, is present, but the involvement of iron in Hao1 regulation remains unclear. In this study, we found a reduction of Hao1 mRNA content in livers of rats with chronic dietary iron overload, which showed decreased IRP activity and higher ferritin expression as expected, but also induction of heme oxygenase (HO-1), a marker of oxidative damage, and lipid peroxidation. Hao1 mRNA levels were not altered significantly in livers of rats administered doses of iron sufficient to induce ferritin expression and to repress IRP activity, but not to activate HO-1 and to promote lipid peroxidation, as well as in the liver of iron-deficient rats. These observations were not consistent with a post-transcriptional down-regulation of Hao1 by iron through the IRE/IRP pathway and suggested an effect of reactive oxygen species (ROS). Indeed, a marked decrease of Hao1 mRNA was observed in the liver of rats subjected to oxidative stress induced by either glutathione depletion or postischemic reperfusion. Nuclear run-on analysis showed an effect of ROS at the transcriptional level. In conclusion, down-regulation of Hao1 expression during oxidative stress may provide a mechanism to prevent excessive H2O2 formation in liver peroxisomes and may represent the prototype of a poorly recognized but potentially relevant response to oxidative injury involving down-regulation of ROS-producing enzymes.
Stereospecific Total Syntheses of Sphingosine and Its Analogues from <scp>l</scp>-Serine (2000)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTStereospecific Total Syntheses of Sphingosine and Its Analogues from l-SerineHideki Azuma, Seizo Tamagaki, and Kenji OginoView Author Information Department of Bioapplied Chemistry, Faculty of Engineering, Osaka City University, Sugimoto 3-3-138, Sumiyoshi-ku, Osaka 558-8585, Japan Cite this: J. Org. Chem. 2000, 65, 11, 3538–3541Publication Date (Web):May 4, 2000Publication History Received14 September 1999Published online4 May 2000Published inissue 1 June 2000https://pubs.acs.org/doi/10.1021/jo991447xhttps://doi.org/10.1021/jo991447xbrief-reportACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1001Altmetric-Citations83LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Column chromatography,Ethers,Mixtures,Reaction products,Solvents Get e-Alerts
Expression and significance of Lgr5 in colorectal carcinoma (2011)

Objective To investigate the expression of leucine-rich-repeat-containing G-protein-coupled receptor 5 (Lgr5) and its significance in colorectal carcinoma. Methods The expression of Lgr5 was examined by immunohistochemistry in 139 cases of colorectal cancer, and its relationship with clinical characteristics was analyzed. Results In 139 colorectal carcinoma samples, the Lgr5 expression rate in tubular adenocarcinoma, mucinous adenocarcinoma, papillary adenocarcinoma was 87.1%, 100.0% and 75.0% respectively. The Lgr5 expression rate in mucous layer, muscular layer, and membrane serosa was 50.0%, 82.6%, 93.9% respectively. High expression levels of Lgr5 were detected in 53 of 56 (94.6%) patients with lymph node metastasis and in 68 of 83 (81.9%) patients without lymph node metastasis. The expression of Lgr5 protein was higher in the tissues with deeper infiltration, advanced Dukes stage, or lymph node or remote metastasis. Conclusion The expression of Lgr5 is significantly correlated with invasion and lymph node metastasis, and may play an important role in the occurrence and development of epithelial colorectal carcinoma. Overexpression of Lgr5 provides an important implication of malignancy and prognosis for colorectal carcinoma.

Key words: 
Colorectal neoplasms;  Lgr5;  Stem cell makers
Estimation of the noise correlation matrix (2011)

To harvest the potential of multi-channel noise reduction methods, it is crucial to have an accurate estimate of the noise correlation matrix. Existing algorithms either assume speech absence and exploit a voice activity detector (VAD), or make use of additional assumptions like a diffuse noise field. Therefore, these algorithms are limited with respect to their tracking speed and the type of noise fields for which they can estimate the correlation matrix. In this paper we present a new method for noise correlation matrix estimation that makes no assumptions about the type of noise field, nor uses a VAD. The presented method exploits the existence of accurate single-channel noise PSD estimators, as well as the avail ability of one noise reference per microphone pair. For spatially and temporally non-stationary noise fields, the proposed method leads to improved performance compared to widely used state-of-the-art reference methods in terms of both segmental SNR and beamformer response error.
[PSD-007 luminescence in the diagnosis of exfoliative cells from malignant tumors]. (1987)

This paper presents the first report in China on the use of luminescence method with hematoporphyrin derivative PSD-007 in the analysis of the exfoliative malignant cells. By this method, pleurorrhea and ascites from 226 suspicious patients were detected. The results showed that its positive rate was 42.23% higher than that of Wright's stain and its positive conformation rate to HE stain could reach as high as 90.2%. Especially, cancer cells could be distinguished from various kinds of non-cancer cells by an objective quantitative analysis of the cellular fluorescent intensity using microfluorophotometer. This new method, being simple, economical and highly specific, is used not only in the qualitative study of the exfoliative tumor cells, but also in the quantitative analysis.
Rouen Conference (1953)

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On Search Engine Evaluation Metrics (2013)

The search engine evaluation research has quite a lot metrics available to it. Only recently, the question of the significance of individual metrics started being raised, as these metrics' correlations to real-world user experiences or performance have generally not been well-studied. The first part of this thesis provides an overview of previous literature on the evaluation of search engine evaluation metrics themselves, as well as critiques of and comments on individual studies and approaches. The second part introduces a meta-evaluation metric, the Preference Identification Ratio (PIR), that quantifies the capacity of an evaluation metric to capture users' preferences. Also, a framework for simultaneously evaluating many metrics while varying their parameters and evaluation standards is introduced. Both PIR and the meta-evaluation framework are tested in a study which shows some interesting preliminary results; in particular, the unquestioning adherence to metrics or their ad hoc parameters seems to be disadvantageous. Instead, evaluation methods should themselves be rigorously evaluated with regard to goals set for a particular study.
Potential Antitumor <i>N</i>-Carbamoyl-<i>N</i>′-methyl-<i>N</i>′-nitroso Derivatives of Amino Acids (1975)

Abstract N-Carbamoyl-N′-methyl-N′-nitroso derivatives of amino acids have been prepared by treating the amino acids with methyl isocyanate followed by nitrosation with sodium nitrite in dilute acetic acid solution.
Self-assembled monolayer molecular devices (2005)

Recent progress in the understanding of nanoscale molecular devices is presented. A control standard is developed and presented, and methods for extracting "band offsets" are presented. The observed peak intensities and peak widths are in good agreement with theoretical predictions.
Side Effects of Hemodialysis (1984)

Long-term hemodialysis for the therapy of endstage kidney disease has dramatically altered the otherwise fatal outcome of progressive renal disease. Clinical experience and technologic advances have reduced many of the difficulties and hazards associated with the procedure. As a result, some 10 per cent of the 55,000 patients on maintenance hemodialysis in the United States are able to perform the procedure at home, and many others undergo dialysis in centers with only limited medical supervision. These creditable achievements notwithstanding, sporadic cases of technical failure and serious complications continue to occur. More distressing to patients, however, are some of the recurrent . . .
Extending the Immediate Buckling Model to Triangular Meshes for Simulating Complex Clothes (2003)

The immediate buckling model is an essential element for simulating realistic cloth animations without introducing buckling instability. The original model is restricted to structured regular quad meshes, by which its use is severely limited. This paper extends the immediate buckling model from its original formulation in terms of regular quad meshes to irregular triangular meshes, thereby significantly increasing the applicability of the technique. Using a model that included cloth-specific buckling and anisotropy, we produced realistic animations of quite complex clothes.
Brain circuit–gene expression relationships and neuroplasticity of multisensory cortices in blind children (2017)

Sensory deprivation reorganizes neurocircuits in the human brain. The biological basis of such neuroplastic adaptations remains elusive. In this study, we applied two complementary graph theory-based functional connectivity analyses, one to evaluate whole-brain functional connectivity relationships and the second to specifically delineate distributed network connectivity profiles downstream of primary sensory cortices, to investigate neural reorganization in blind children compared with sighted controls. We also examined the relationship between connectivity changes and neuroplasticity-related gene expression profiles in the cerebral cortex. We observed that multisensory integration areas exhibited enhanced functional connectivity in blind children and that this reorganization was spatially associated with the transcription levels of specific members of the cAMP Response Element Binding protein gene family. Using systems-level analyses, this study advances our understanding of human neuroplasticity and its genetic underpinnings following sensory deprivation.
SDM: a server for predicting effects of mutations on protein stability (2017)

Here, we report a webserver for the improved SDM, used for predicting the effects of mutations on protein stability. As a pioneering knowledge-based approach, SDM has been highlighted as the most appropriate method to use in combination with many other approaches. We have updated the environment-specific amino-acid substitution tables based on the current expanded PDB (a 5-fold increase in information), and introduced new residue-conformation and interaction parameters, including packing density and residue depth. The updated server has been extensively tested using a benchmark containing 2690 point mutations from 132 different protein structures. The revised method correlates well against the hypothetical reverse mutations, better than comparable methods built using machine-learning approaches, highlighting the strength of our knowledge-based approach for identifying stabilising mutations. Given a PDB file (a Protein Data Bank file format containing the 3D coordinates of the protein atoms), and a point mutation, the server calculates the stability difference score between the wildtype and mutant protein. The server is available at http://structure.bioc.cam.ac.uk/sdm2.
A submicron aerosol mode in flue gas from a pulverized coal utility boiler (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleA submicron aerosol mode in flue gas from a pulverized coal utility boilerG. R. Markowski, D. S. Ensor, R. G. Hooper, and R. C. CarrCite this: Environ. Sci. Technol. 1980, 14, 11, 1400–1402Publication Date (Print):November 1, 1980Publication History Published online1 May 2002Published inissue 1 November 1980https://pubs.acs.org/doi/10.1021/es60171a008https://doi.org/10.1021/es60171a008research-articleACS PublicationsRequest reuse permissionsArticle Views216Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Phoneme (2011)

The concept of the phoneme was central to the development of phonological theory. In the early twentieth century, phonological theory was all about the phoneme: how to define it, how to recognize it, how to discover it (see, for example, the articles selected for inclusion in Joos 1957 and Makkai 1972). The American structuralist term for phonology, phonemics, indicates to what extent the field was considered to be about the phoneme.
<title>Pseudorandom encoding of fully complex modulation to biamplitude phase modulators</title> (1996)

Pseudorandom encoding is a statstica11ybased, pixel-by-pixel mapping of complex valued modulations Auto modul6tors that do not produce a!! comp1e values.' The resulting far-field 1iffraction pattern closely approximates that from the desired, but unimplementabic, complex modulation. Since the methed is point-oriented, the desired complex modulation can be synthesized and encoded without resorting to time consuming constrained global optimizations e.g. simulated anneding,4 genetic,3 and Gerchberg Saxton4 algorithms. In addition to reducing design time, the resulting diffraction patterns can have reasonably high diffraction efficiencies and low levels of background noise.
Video Error Concealment Using Spatio-Temporal Boundary Matching and Partial Differential Equation (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Error concealment techniques are very important for video communication since compressed video sequences may be corrupted or lost when transmitted over error-prone networks. In this paper, we propose a novel two-stage error concealment scheme for erroneously received video sequences. In the first stage, we propose a novel spatio-temporal boundary matching algorithm (STBMA) to reconstruct the lost motion vectors (MV). A well defined cost function is introduced which exploits both spatial and temporal smoothness properties of video signals. By minimizing the cost function, the MV of each lost macroblock (MB) is recovered and the corresponding reference MB in the reference frame is obtained using this MV. In the second stage, instead of directly copying the reference MB as the final recovered pixel values, we use a novel partial differential equation (PDE) based algorithm to refine the reconstruction. We minimize, in a weighted manner, the difference between the gradient field of the reconstructed MB in current frame and that of the reference MB in the reference frame under given boundary condition. A weighting factor is used to control the regulation level according to the local blockiness degree. With this algorithm, the annoying blocking artifacts are effectively reduced while the structures of the reference MB are well preserved. Compared with the error concealment feature implemented in the H.264 reference software, our algorithm is able to achieve significantly higher PSNR as well as better visual quality. </para>
Solar Energy Technologies Program Peer Review: Center for Nanoscale Energy (2010)

The purpose of this project is to develop plant-derived polymers with high potential for replacing petroleum-derived polymers. Important considerations include reduced swelling, lower price, equal or greater strength, and improved processability. Polymer precursors and other high value chemicals are derived by selective oxidation of renewable resources including oil seeds and cellulosics. High throughput combinatorial methods were applied to optimize oxidative catalysis as well as to formulate polymer families. Long chain dicarboxylic acids have been derived in >80% yields from fatty acids found in oil seeds by selective oxidative cleavage using tungsten-based and other catalysts. Furan dicarboxylic acids have been synthesized in high yields by selective catalytic oxidation of cellulosic materials. This product is a precursor to a new class of polyamide polymers. A series terephthalamide/adipamide copolymers have been prepared from long-chain dicarboxylic acids derived from renewable feedstocks. Compositions have been identified that exhibit significant processing advantages over commercial nylons.
TRIM72 is required for effective repair of alveolar epithelial cell wounding (2014)

The molecular mechanisms for lung cell repair are largely unknown. Previous studies identified tripartite motif protein 72 (TRIM72) from striated muscle and linked its function to tissue repair. In this study, we characterized TRIM72 expression in lung tissues and investigated the role of TRIM72 in repair of alveolar epithelial cells. In vivo injury of lung cells was introduced by high tidal volume ventilation, and repair-defective cells were labeled with postinjury administration of propidium iodide. Primary alveolar epithelial cells were isolated and membrane wounding and repair were labeled separately. Our results show that absence of TRIM72 increases susceptibility to deformation-induced lung injury whereas TRIM72 overexpression is protective. In vitro cell wounding assay revealed that TRIM72 protects alveolar epithelial cells through promoting repair rather than increasing resistance to injury. The repair function of TRIM72 in lung cells is further linked to caveolin 1. These data suggest an essential role for TRIM72 in repair of alveolar epithelial cells under plasma membrane stress failure.