gebhart/patrepeval huggingface dataset:
Fluorescent Probes in Studies of Proteases (1993)

Proteases are involved in a wide spectrum of biological functions, including regulatory, catabolic, metabolic and pathologic processes. We have designed and synthesized internally quenched fluorogenic protease substrate probes that enable enzymology of purified, characterized proteases such as HIV protease and renin, which are targets for therapeutic intervention in AIDS and hypertension, respectively. We have also developed fluorogenic substrate probes that permit the search for unknown or uncharacterized proteases with putative cleavage functions that may be associated with particular disease processes, such as β/A4 amyloid formation in Alzheimer's disease. In this chapter, applications of these substrate probes in studies pertaining to HIV protease, renin, and putative Alzheimer's disease associated proteases are described.
Collective phenomena in volume and surface barrier discharges (2010)

Barrier discharges are increasingly used as a cost-effective configuration to produce non-equilibrium plasmas at atmospheric pressure. This way, copious amounts of electrons, ions, free radicals and excited species can be generated without significant heating of the background gas. In most applications the barrier is made of dielectric material. Major applications utilizing mainly dielectric barriers include ozone generation, surface cleaning and modification, polymer and textile treatment, sterilization, pollution control, CO2 lasers, excimer lamps, plasma display panels (flat TV screens). More recent research efforts are devoted to biomedical applications and to plasma actuators for flow control. Sinusoidal feeding voltages at various frequencies as well as pulsed excitation schemes are used. Volume as well as surface barrier discharges can exist in the form of filamentary, regularly patterned or diffuse, laterally homogeneous discharges. The physical effects leading to collective phenomena in volume and surface barrier discharges are discussed in detail. Special attention is paid to self-organization of current filaments and pattern formation. Major similarities of the two types of barrier discharges are elaborated.
Inhibitory effect of capsaicin on mouse lung tumor development. (1992)

The modification potentials of capsaicin on the development of pulmonary adenoma in newborn NIH (GP) mice were examined. Mice were given a single subcutaneous injection of 1 mg of benzo(a)pyrene (BP) or 40 micrograms of 9,10-demethyl-1,2-benzanthracene (DMBA) within 24 hours after birth and then 0.01% capsaicin (CAP) in the diet (Groups 1 and 2) for 6 weeks after weaning. Mice of groups 3, 4, 5 and 6 were given capsaicin, BP, DMBA and vehicle alone. All mice were sacrificed at week 9. Capsaicin caused a significant inhibitory effect on the frequency of tumor-bearing mice (BP-treated group) and the mean number of tumor (DMBA-treated group). The inhibitory activity is most profound in the group of female mice given DMBA combined with capsaicin. These results showed that capsaicin has inhibitory potential in the mouse lung tumor development induced by polycyclic aromatic hydrocarbons (BP and DMBA).
On Extendable Software Architecture for Spam Email Filtering (2007)

The research community and the IT industry have invested significant effort in fighting spam emails. There are many different approaches, ranging from white listing, black listing, reputation ranking, postage, legislation, and content scanning etc. Until every ISP obeys the same rules, content scanning based spam email filters still have a significant role to play in fighting spam emails. There are many content scanning based spam email filters available and also in operation. Yet we are still inundated with spam emails everyday. This is not because the filters are not powerful enough, but because the filtering systems are not flexible enough to adapt the new development of spam techniques, such as HTML tagging, image based spam, and keyword obfuscating etc. In this paper, we propose to use dynamic multiple normalizers as the preprocessors for spam filters. The normalizers convert an email to its plain text format, called normalization. With the help of the normalizers, spam filters only need to deal with plain text format, which is what the filters are good at. The flexibility of the proposed architecture does not only make the adoption to the new creations of spammers easier but also makes the integration to the other spam fighting technologies easier.
Assay and Properties of Serum Inhibitor of C'1-Esterase (1959)

An assay is described for measurement of a serum inhibitor of an esterase derived from preparations of the first component of complement (C'1-esterase). Esterolysis of N-acetyl-L-tyrosine ethyl ester by C'1-esterase is inhibited instantaneously and stoichiometrically by fresh human serum. Units of C'1-esterase and of serum inhibitor are defined. The inhibitor in human serum is stable at 45 for at least 4 months, at 37° for at least 24 hr. and at 48° for at least 30 min. It is completely inactivated during 30 min. incubation at 60° and is labile at 0° at pH values below 6. The inhibitor is inactivated at —5 in the presence of methanol concentrations of 15° or greater but is recovered quantitatively in a 40° ammonium sulfate supernatant fraction. These data are being applied to purification of the inhibitor from human serum. Purification procedures and properties of the purified inhibitor will be reported elsewhere.
Lecture notes on C*-algebras, Hilbert C*-modules, and quantum mechanics (1998)

This is a graduate-level introduction to C*-algebras, Hilbert C*-modules, vector bundles, and induced representations of groups and C*-algebras, with applications to quantization theory, phase space localization, and configuration space localization. The reader is supposed to know elementary functional analysis and quantum mechanics.
A Recommendation System to Facilitate Business Process Modeling (2016)

This paper presents a system that utilizes process recommendation technology to help design new business processes from scratch in an efficient and accurate way. The proposed system consists of two phases: 1) offline mining and 2) online recommendation. At the first phase, it mines relations among activity nodes from existing processes in repository, and then stores the extracted relations as patterns in a database. At the second phase, it compares the new process under construction with the premined patterns, and recommends proper activity nodes of the most matching patterns to help build a new process. Specifically, there are three different online recommendation strategies in this system. Experiments on both real and synthetic datasets are conducted to compare the proposed approaches with the other state-of-the-art ones, and the results show that the proposed approaches outperform them in terms of accuracy and efficiency.
Microwave tumor detection using a flexible UWB elliptical slot antenna with a tuning uneven U-shape stub on LCP (2007)

In this paper, we investigate tumor detection capabilities of the CPW-fed Elliptical Slot Antenna with a Tuning Uneven U-shape Stub on flexible liquid crystal polymer (LCP) in the UWB Microwave range of frequencies. The software “Microstripes” (based on FDTD) is used in our work to develop a realistic breast model and to analyze the tumor response of several tumors with different sizes and orientations.
TRPV1 Potentiates TGFβ-Induction of Corneal Myofibroblast Development through an Oxidative Stress-Mediated p38-SMAD2 Signaling Loop (2013)

Injuring mouse corneas with alkali causes myofibroblast expression leading to tissue opacification. However, in transient receptor potential vanilloid 1 channel (TRPV1-/-) knockout mice healing results in transparency restoration. Since TGFβ is the primary inducer of the myofibroblast phenotype, we examined the mechanism by which TRPV1 affects TGFβ-induced myofibroblast development. Experiments were performed in pig corneas and human corneal fibroblasts (HCFs). Immunohistochemical staining of α-smooth muscle actin (α-SMA) stress fibers was used to visualize myofibroblasts. Protein and phosphoprotein were determined by Western blotting. siRNA transfection silenced TRPV1 gene expression. Flow cytometry with a reactive oxygen species (ROS) reporting dye analyzed intracellular ROS. [Ca2+]I was measured by loading HCF with fura2. In organ cultured corneas, the TRPV1 antagonist capsazepine drastically reduced by 75% wound-induced myofibroblast development. In HCF cell culture, TGF-β1 elicited rapid increases in Ca2+ influx, phosphorylation of SMAD2 and MAPKs (ERK1/2, JNK1/2 and p38), ROS generation and, after 72 hrs myofibroblast development. SMAD2 and p38 activation continued for more than 16 h, whereas p-ERK1/2 and p-JNK1/2 waned within 90 min. The long-lived SMAD2 activation was dependent on activated p38 and vice versa, and it was essential to generate a > 13-fold increase in α-SMA protein and a fully developed myofibroblast phenotype. These later changes were markedly reduced by inhibition of TRPV1 or reduction of the ROS generation rate. Taken together our results indicate that in corneal derived fibroblasts, TGFβ- induced myofibroblast development is highly dependent on a positive feedback loop where p-SMAD2-induced ROS activates TRPV1, TRPV1 causes activation of p38, the latter in turn further enhances the activation of SMAD2 to establish a recurrent loop that greatly extends the residency of the activated state of SMAD2 that drives myofibroblast development.
Preparation of Polyborazylene-Derived Bulk Boron Nitride with Tunable Properties by Warm-Pressing and Pressureless Pyrolysis (2010)

The polymer-derived ceramics (PDCs) route has been combined with a warm-pressing process to synthesize for the first time boron nitride workpieces avoiding the conventional sintering process. A polyborazylene was synthesized with a controlled degree of cross-linking suitable to be warm-pressed into cylindrical green bodies which were pressureless pyrolyzed into disk-shaped boron nitride workpieces. On the basis of elemental analyses, differential scanning calorimetry (DSC), and thermomechanical analyses (TMA), the best polyborazylene candidates are those prepared by self-condensation of borazine (B3N3H6) at 60 °C under static argon in an autoclave. They displayed a chemical formula of [B3.0N3.5H4.5]n, a glass transition in the temperature range 88−120 °C, a controlled dimensional change upon heating under load and a high ceramic yield. Such properties provided (i) adjusted viscoelastic properties and sufficient plasticity to be warm-pressed under 74 MPa at 60 °C into disk-shaped bodies with 13 mm in diameter in a stable operation and (ii) retention of the polymer shape during the further pyrolysis at 1450 °C in a nitrogen atmosphere. Disk-shaped B3.0N2.95 workpieces with a relative density of 86.3% were obtained. Solid-state 11B NMR has been used to investigate the polyborazylene-to-BN conversion while XRD, SEM, and He-pycnometry have been performed on workpieces pyrolyzed between 1450 and 1800 °C. Densification occurred in this range to generate bulk boron nitride (B3.0N2.9) with a relative density as high as ∼93%.
First field trial of fox vaccination against rabies using a vaccinia-rabies recombinant virus (1988)

A field trial of fox vaccination against rabies using a vaccinia-rabies recombinant virus was carried out in Belgium on October 24, 1987. Each vaccine capsule contained a suspension of 10(8) TCID50 of the recombinant virus and was introduced into a chicken head. Each chicken head contained 150 mg of tetracycline as a marker of uptake. Two hundred and fifty heads were distributed in an area of 6 km2 situated within a military zone. The bait uptake was monitored for 15 days after the distribution. Sixty-three per cent of the chicken heads were taken by wild animals within that period. The trial was controlled according to the rules defined by the World Health Organisation.
Toward High-Performance Polymer Solar Cells:  The Importance of Morphology Control (2007)

Polymer solar cells have the potential to become a major electrical power generating tool in the 21st century. R&D endeavors are focusing on continuous roll-to-roll printing of polymeric or organic compounds from solutionlike newspapersto produce flexible and lightweight devices at low cost. It is recognized, though, that besides the functional properties of the compounds the organization of structures on the nanometer levelforced and controlled mainly by the processing conditions applieddetermines the performance of state-of-the-art polymer solar cells. In such devices the photoactive layer is composed of at least two functional materials that form nanoscale interpenetrating phases with specific functionalities, a so-called bulk heterojunction. In this perspective article, our current knowledge on the main factors determining the morphology formation and evolution is introduced, and gaps of our understanding on nanoscale structure−property relations in the field of high-performance polymer solar cells are addressed. Finally, promising routes toward formation of tailored morphologies are presented.
Parallel Comparison of Sandwich and Direct Label Assay Protocols on Cytokine Detection Protein Arrays (2003)

This study describes a systematic comparison of the preparation, sensitivity, and response of direct label and sandwich fluoroimmunoassay protein arrays for parallel detection of cytokines and growth factors. Five model analytes were examined, IL-1β, TNF-α, VEGF, MIP-1β, and TGF- β1, as well as four different array printing slides. Each slide was printed with four identical anti-cytokine arrays, two arrays employed for direct labeling and two for sandwich assays. All five target cytokines assayed using the sandwich format significantly outperformed the corresponding direct label assays in terms of background-subtracted fluorescent intensity, although the extent varied for different cytokines, growth factors, and slides examined. Binding of target protein by immobilized capture antibody was examined by Biacore surface plasmon resonance with and without labeling of the target protein. A major explanation for the superior performance of the sandwich assay protocol was the dilution of the labeled target cytokine in the size exclusion gel filtration column during labeling procedure. Other possible explanations included that binding of the detection antibody-induced signal amplification, and labeling of target cytokine reduced efficiency of cytokine binding to immobilized capture antibody.
Excursion ENS - Problèmes agraires en Norvège centrale (1961)

Estienne Pierre, Moreau Jean-Paul. Excursion ENS - Problèmes agraires en Norvège centrale. In: Annales de Géographie, t. 70, n°381, 1961. Le XIXe congrès international de géographie Stockholm, août 1960, sous la direction de Max Sorre. pp. 546-548.
Debating Thailand's September 2006 military coup d'état (2007)

Introduktion til tema nummer om baggrunden for og følgerne af militærkuppet i Thailand i September 2006.<br /> Udgivelsesdato: December
Radiopharmaceutical Chemistry between Imaging and Endoradiotherapy (2015)

The fields of molecular biology, immunology and genetics have generated many important developments that advance the understanding of the induction and progression of oncological, cardiological and neurological diseases as well as the identification of disease-associated molecules and drugs that specifically target diseased cells during therapy
Diverse, High-Quality Test Set for the Validation of Protein−Ligand Docking Performance (2007)

A procedure for analyzing and classifying publicly available crystal structures has been developed. It has been used to identify high-resolution protein-ligand complexes that can be assessed by reconstructing the electron density for the ligand using the deposited structure factors. The complexes have been clustered according to the protein sequences, and clusters have been discarded if they do not represent proteins thought to be of direct interest to the pharmaceutical or agrochemical industry. Rules have been used to exclude complexes containing non-drug-like ligands. One complex from each cluster has been selected where a structure of sufficient quality was available. The final Astex diverse set contains 85 diverse, relevant protein-ligand complexes, which have been prepared in a format suitable for docking and are to be made freely available to the entire research community (http://www.ccdc.cam.ac.uk). The performance of the docking program GOLD against the new set is assessed using a variety of protocols. Relatively unbiased protocols give success rates of approximately 80% for redocking into native structures, but it is possible to get success rates of over 90% with some protocols.
Titration of Tetanal Toxins, Toxoids and Antitoxins with the Flocculative Test (1942)

Journal Article Titration of Tetanal Toxins, Toxoids and Antitoxins with the Flocculative Test Get access Horace Goldie, Horace Goldie From the Lederle Laboratories, Pearl River, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Carr H. Parsons, Carr H. Parsons From the Lederle Laboratories, Pearl River, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Myrtle Scott Bowers Myrtle Scott Bowers From the Lederle Laboratories, Pearl River, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 71, Issue 3, November 1942, Pages 212–219, https://doi.org/10.1093/infdis/71.3.212 Published: 01 November 1942 Article history Received: 18 February 1942 Published: 01 November 1942
Karyological Studies on Seven Cephalopods (1990)

Karyological studies were made on the embryos of seven cephalopods using chopping method. Two sepiids (Sepia esculenta and Sepia lycidas) and three loliginids (Sepioteuthis lessoniana, Heterololigo bleekeri and Photololigo edulits) were all 2n = 92). Their karyotypes and total length of chromosomes were slightly different from each other. Two octopuses (Octopus ocellatus and O. vulgaris) were both 2n=60. Their karyotypes and total length of chromosomes were, however, remarkably different from each other.
1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo (1997)

N-(3-(Aminomethyl)benzyl)acetamidine (1400W) was a slow, tight binding inhibitor of human inducible nitric- oxide synthase (iNOS). The slow onset of inhibition by 1400W showed saturation kinetics with a maximal rate constant of 0.028 s-1 and a binding constant of 2.0 microM. Inhibition was dependent on the cofactor NADPH. L-Arginine was a competitive inhibitor of 1400W binding with a Ks value of 3.0 microM. Inhibited enzyme did not recover activity after 2 h. Thus, 1400W was either an irreversible inhibitor or an extremely slowly reversible inhibitor of human iNOS with a Kd value </= 7 nM. In contrast, inhibition of human neuronal NOS and endothelial NOS (eNOS) was relatively weaker, rapidly reversible, and competitive with L-arginine, with Ki values of 2 microM and 50 microM, respectively. Thus, 1400W was at least 5000-fold selective for iNOS versus eNOS. This selectivity was similar to that observed in rat aortic rings, in which 1400W was greater than 1000-fold more potent against rat iNOS than eNOS. Finally, 1400W was greater than 50-fold more potent against iNOS than eNOS in a rat model of endotoxin-induced vascular injury. Thus, the potency and selectivity of 1400W inhibition of iNOS both in vitro and in vivo were far greater than of any previously described iNOS inhibitor.
Synthesis and Characterization of Ru(II) Tris(1,10-phenanthroline)-Electron Acceptor Dyads Incorporating the 4-Benzoyl-<i>N</i>-methylpyridinium Cation or <i>N</i>-Benzyl-<i>N</i>‘-methyl Viologen. Improving the Dynamic Range, Sensitivity, and Response Time of Sol−Gel-Based Optical Oxygen Sensors (2004)

The title compounds were synthesized by Sonogashira coupling reactions of appropriate Ru(II) complexes with the electron acceptors. Characterization was conducted in solution and in frozen matrixes. Finally, the title compounds were evaluated as dopants of sol−gel materials. It was found that the intramolecular quenching efficiency of 4-benzoyl-N-methylpyridinium cation in solution depends on the solvent: photoluminescence is quenched completely in CH3CN, but not in methanol or ethanol. On the other hand, intramolecular emission quenching by 4-benzyl-N-methyl viologen is complete in all solvents. The difference between the two quenchers is traced electrochemically to the solvation of the 4-benzoyl-N-methylpyridiniums by alcohol. In frozen matrixes or adsorbed on the surfaces of silica aerogel, both Ru(II) complex/electron acceptor dyads of this study are photoluminescent, and the absence of quenching has been traced to the environmental rigidity. When doped aerogels are cooled at 77 K, the emission intensity increases by ∼4×, and the spectra shift to the blue, analogous to what is observed with Ru(II) complexes in solutions undergoing fluid-to-rigid transition. However, in contrast to frozen solutions, the luminescent moieties in the bulk of aerogels kept at low temperatures are still accessible to gas-phase quenchers diffusing through the mesopores, leading to more sensitive platforms for sensors than other room-temperature configurations. Thus, the photoluminescence of our Ru(II) complex dyads adsorbed on aerogel is quenchable by O2 both at room temperature and at 77 K. Furthermore, it was also found that O2 modulates the photoluminescence of aerogels doped with 4-benzoyl-N-methylpyridinium -based dyads over a wider dynamic range compared with aerogels doped with either our viologen-based dyads or with Ru(II) tris(1,10-phenanthroline) itself.
Practical synthesis of BINAP-ruthenium(II) dicarboxylate complexes (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPractical synthesis of BINAP-ruthenium(II) dicarboxylate complexesMasato Kitamura, Makoto Tokunaga, and Ryoji NoyoriCite this: J. Org. Chem. 1992, 57, 14, 4053–4054Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/jo00040a068https://doi.org/10.1021/jo00040a068research-articleACS PublicationsRequest reuse permissionsArticle Views1087Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prevalence of Cardiac Amyloidosis in Patients Referred for Transcatheter Aortic Valve Replacement (2018)

Valve ReplacementAortic stenosis (AS) is the most common valve disease in the developed world.Symptomatic severe