gebhart/patrepeval huggingface dataset:
Clinical Gene Transfer Studies for Hemophilia A (2004)

The recent advances in gene transfer technology have expedited the development of gene therapy for the treatment of hemophilia A. Three different U.S. Food and Drug Administration-approved phase I clinical trials had been initiated using different gene therapy approaches each with their own advantages and limitations. In the first gene therapy trial for hemophilia A, a non-viral approach was being explored for patients with severe hemophilia A using ex vivo transfected dermal fibroblast expressing B-domain-deleted factor VIII ( BDD-FVIII). There were no serious adverse events and some patients appeared to have experienced fewer bleeding episodes with very low levels of FVIII near baseline. In the second trial, onco-retroviral vectors expressing BDD-FVIII were injected by peripheral intravenous infusion in adult patients suffering from severe hemophilia A. The procedure was safe and in some patients FVIII-transduced cells were detectable in the peripheral blood for more than a year. Although no sustained FVIII expression was detectable, occasional modest changes in FVIII levels were apparent, and in some cases a reduced bleeding frequency occurred compared with historical rates. In another trial, one patient suffering from severe hemophilia A has been treated with a high-capacity (or gutless) adenoviral vector expressing full-length FVIII, which appeared to have resulted in 1% of normal FVIII levels for several months. However, a transient inflammatory response with hematologic and liver abnormalities was observed. In conclusion, although modest improvements in clinical end points have been detected in some patients in these early phase I trials, further improvements in gene delivery technologies are warranted to bring hemophilia A gene therapy one step closer to reality.
Role of Caveolin-1 in the Regulation of Pulmonary Endothelial Permeability (2011)

Endothelial permeability measurements of intact vascular beds and monolayer cultures are used to describe transport of small molecules (ions, water, and nutrients), macromolecules and plasma protein across the vascular endothelia. Disruption of the endothelial barrier leads to vascular hyper-permeability and protein-rich edema which is a key hallmark of inflammation. Transport of the most abundant plasma protein, albumin, occurs by means of transcellular and paracellular pathways. In healthy, noninflamed vessels, endothelial cell-cell contacts significantly restrict the paracellular permeability of albumin, whereas its transcellular transport from the blood to the abluminal perivascular interstitium occurs via caveolae. Thus, caveolae-mediated transport is a primary determinant of the basal endothelial permeability properties. Increased paracellular permeability induced during inflammation is thought to be due to the opening of interendothelial cell-cell junctions and disruption of endothelial cell-matrix contacts within the vasculature. We recently demonstrated that caveolae-mediated transendothelial transport (transcytosis) of macromolecules through the microvascular endothelial barrier is also an important mechanism responsible for inflammation-evoked pulmonary vascular hyperpermeability and protein-rich edema formation. Moreover, caveolin-1, a structural and scaffolding protein required for caveolae formation and transcellular transport, also plays an important role in oxidant-induced paracellular hyperpermeability. This review highlights the methods used to assess transcellular and paracellular permeability properties of the intact mouse lung and cultured endothelial cell monolayers.
A novel cell‐adhesive scaffold material for delivering keratinocytes reduces granulation tissue in dermal wounds (2009)

Novel peptide-conjugated chitosan membranes were fabricated and used to deliver keratinocytes to dermal wounds in mice. Three active peptides of 12 or 13 amino acids each, RLVSYNGIIFFLK (A5G27), ASKAIQVFLLAG (A5G33), and AGTFALRGDNPQG (A99) were selected from a cell-adhesive peptide library of laminin, a major constituent of basement membrane. The peptides were synthesized and coupled to chitosan membranes, and the resulting peptide-chitosan membranes were tested for keratinocyte attachment. Two of the peptides that bind to cell surface heparin-like receptors (A5G27 and A5G33) were found to promote strong keratinocyte attachment, whereas the one that binds to integrin (A99) was inactive. Subsequently, A5G27- and A5G33-chitosan membranes were tested as vehicles for keratinocyte delivery in a wound model. We found that keratinocytes were delivered into the full-thickness wound with either membrane. Using the A5G33-chitosan membrane, we further evaluated the activity of the delivered keratinocytes in wound healing. Immunohistochemistry for granulation tissue markers, including tenascin and alpha-smooth muscle actin, showed that keratinocyte delivery by the present peptide-chitosan membranes in the wound bed provided a favorable condition for keratinocyte migration along the wound surface and reduced granulation tissue formation.
Experimental investigations of oxygen-separating ion transport membranes for clean fuel synthesis (2015)

Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2015.
Growth of host cells and Chlamydia trachomatis in medium containing serum from 16-week-old calves (1983)

We compared fetal bovine serum with five batches of serum from calves of various ages. HeLa and McCoy cells grown in only one batch of calf serum (from 16-week-old calves) had morphology, growth kinetics, and cloning efficiency similar to those of cells grown in fetal bovine serum. Cells maintained in calf serum from this batch supported the growth of two laboratory strains of Chlamydia trachomatis, a genital strain (E/UW-5/Cx) in McCoy cells and a lymphogranuloma venereum strain (440L) in HeLa cells. McCoy cells maintained in calf serum also supported the growth of C. trachomatis from clinical specimens. The batch of serum from 16-week-old calves was an effective alternative to fetal bovine serum for the growth of cells and of C. trachomatis. Other laboratories may be able to use calf serum for the maintenance of cells and for the isolation of Chlamydia spp. Before use, however, each batch of calf serum will have to be carefully evaluated to ensure that it is equivalent to fetal bovine serum.
Chemical Durability of Silicon Oxycarbide Glasses (2002)

Silicon oxycarbide (SiOC) glasses with controlled amounts of Si—C bonds and free carbon have been produced via the pyrolysis of suitable preceramic networks. Their chemical durability in alkaline and hydrofluoric solutions has been studied and related to the network structure and microstructure of the glasses. SiOC glasses, because of the character of the Si—C bonds, exhibit greater chemical durability in both environments, compared with silica glass. Microphase separation into silicon carbide (SiC), silica (SiO 2 ), and carbon, which usually occurs in this system at pyrolysis temperatures of >1000°–1200°C, exerts great influence on the durability of these glasses. The chemical durability decreases as the amount of phase separation increases, because the silica/silicate species (without any carbon substituents) are interconnected and can be easily leached out, in comparison with the SiOC phase, which is resistant to attack by OH − or F − ions.
Grain Protectant Efficacy of Makabuhay, Tinospora rumphii Extract Against Maize Weevil, Sitophilus zeamais M. (2015)

The grain protectant efficacy of Makabuhay, Tinospora rumphii stem extract was tested on adult maize weevil, Sitophilus zeamais M. Evaluation of phytochemicals present in the extract was conducted to identify its bioactive compounds. The ethanolic stem extract of T. rumphii contains the following phytochemicals: alkaloids, flavonoids, steroids and tannins. These phytochemicals are known to possess pesticidal activities against insects and other pests. The grain protectant efficacy of T. rumphii against corn weevils was manifested by the percentage of mortality of weevils, number of corn seed holes; weight loss and percentage corn germination. Results revealed that the corn weevils treated with the highest concentration (18%) of T. rumphii manifest the highest percentage of weevils’ mortality and significantly higher (p =0.000) as compared to the negative control and the other treatment concentrations. In addition, the mortality of corn weevils treated with the plant extract is concentration-dependent. The average number of corn seed holes treated the T. rumphii extract is statistically lower as compared to the negative control. Moreover, the highest concentration (18%) of the plant extract showed the lowest average number of holes. This implies that T. rumphii is responsible for the inhibition of the weevils from infesting the corn seeds. Furthermore, result revealed significant decrease (p =0.000) on the average weight loss of corn seeds previously treated with the plant extract. The highest concentration of T. rumphii manifest the lowest percentage weight loss. Result also showed a significant increase (p = 0.000) of percentage germination of corn seeds randomly selected from the control and the treated groups. The highest concentration of the plant extract reveals the highest percentage of germination. T. rumphii stem extract therefore is an effective grain protectant against maize weevis, S. zeamis due to the presence of phytochemicals flavonoids, alkaloids, steroids and tannins which showed synergistic effects in terms of insecticidal action to maize weevil.
Note on the text (2005)

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Protrusio After Medial Acetabular Wall Breach in Total Hip Arthroplasty. (2015)

Osteoporotic patients with a medial wall defect after hip arthroplasty may be susceptible to fracture during activities of daily living. Protected weight bearing with an assistive device may be reasonable in order to minimize fall risk until cup ingrowth is achieved.
경찰직,일반 행정직 공무원의 직무스트레스 및 직무만족에 대한 비교 연구 (2016)

본 연구는 상사리더십과 조직공정성이 직무스트레스 및 직무만족에 미치는 영향에 대해 살펴보고, 경찰조직 및 일반 행정조직간에 이러한 구조와 영향성에 차이가 있는지에 대해 검증하고자한다. 변수간 영향정도의 분석결과, 직무스트레스는 직무만족에 부(-)적, 리더십·조직공정성은 직무만족에 각각 정(+)적, 리더십·조직공정성은 직무스트레스에 각각 부(-)적으로 유의미한 영향을 주고 있음을 확인하였다. 경찰조직과 일반 행정조직 간의 차이를 살펴보면, 먼저 변수들의 평균값에서 조직공정성을 제외한 모든 변수에서 두 집단 간의 유의미한 차이가 있었다. 다중집단분석을 통한 검증에서도 두 집단 간의 경로계수와 영향정도에 차이가 있음이 확인되었다. 구체적으로 일반 행정조직에 비해 경찰조직에서 상사리더십과 조직공정성이 직무스트레스 및 직무만족에 미치는 영향이 유의미하게 크다는 것이 확인되었다. 이상의 연구결과를 바탕으로 일반 행정조직과 구별되는 경찰조직의 특수성을 고려하여 학술적, 실제적 차원에서 경찰 조직에 효용성 있는 해석과 활용에 대해 논의하였다.
ISTA-Net: Interpretable Optimization-Inspired Deep Network for Image Compressive Sensing (2018)

With the aim of developing a fast yet accurate algorithm for compressive sensing (CS) reconstruction of natural images, we combine in this paper the merits of two existing categories of CS methods: the structure insights of traditional optimization-based methods and the speed of recent network-based ones. Specifically, we propose a novel structured deep network, dubbed ISTA-Net, which is inspired by the Iterative Shrinkage-Thresholding Algorithm (ISTA)for optimizing a general ℓ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> norm CS reconstruction model. To cast ISTA into deep network form, we develop an effective strategy to solve the proximal mapping associated with the sparsity-inducing regularizer using nonlinear transforms. All the parameters in ISTA-Net (e.g. nonlinear transforms, shrinkage thresholds, step sizes, etc.) are learned end-to-end, rather than being hand-crafted. Moreover, considering that the residuals of natural images are more compressible, an enhanced version of ISTA-Net in the residual domain, dubbed ISTA-Net+, is derived to further improve CS reconstruction. Extensive CS experiments demonstrate that the proposed ISTA-Nets outperform existing state-of-the-art optimization-based and networkbased CS methods by large margins, while maintaining fast computational speed. Our source codes are available: http://jianzhang.tech/projects/ISTA-Net.
An efficient algorithm for computation of manipulator inertia matrix (1990)

Abstract In this article an efficient algorithm for computation of the manipulator inertia matrix is presented. The algorithm is derived based on Newton's and Euler's laws governing the motion of rigid bodies. Using spatial notations, the algorithm leads to the definition of the composite rigid‐body spatial inertia which is a spatial representation of the notion of augmented body. The equations resulting from this algorithm are derived in a coordinate‐free form. The choice of the coordinate frame for projection of the coordinate‐free equations, that is, the intrinsic equations, is discussed by analyzing the vectors and the tensors involved in the final equations. Previously proposed algorithms, the physical interpretations leading to their derivation, and the redundancy in their computations are analyzed. The developed algorithm achieves a greater efficiency by eliminating the redundancy in the intrinsic equations as well as by a suitable choice of coordinate frame for projection of the intrinsic equations.
Response of an optical cavity to phase-controlled incomplete power switching of nearly resonant incident light (2018)

The response of an optical cavity to incomplete extinction of nearly resonant incident light was experimentally examined. Measurements were performed using a Pound-Drever-Hall-locked frequency-stabilized cavity ring-down spectrometer (CRDS) that allowed the laser frequency detuning from the cavity resonance center to be controlled at Hz-level resolution. It is shown that an insufficient laser light extinction ratio combined with a phase shift and frequency detuning may lead to non-exponential cavity pumping and decay signals. The experimental results can be explained with a simple analytical model. The non-exponential decay can lead to a systematic shift as high as 0.5% in the ring-down time constants, dependent on the laser frequency detuning from the cavity mode center and on the extinction ratio. This can lead to appreciable systematic errors in the absorption coefficients determined with the CRDS technique.
The Electromotive Force of the Cell H<sub>2</sub>, HCl(g), AgCl(s), Ag(s) at 25°. Derived Values from 0 to 40°<sup>2</sup> (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Electromotive Force of the Cell H2, HCl(g), AgCl(s), Ag(s) at 25°. Derived Values from 0 to 40°2J. G. Aston and Frank L. GittlerCite this: J. Am. Chem. Soc. 1955, 77, 12, 3173–3174Publication Date (Print):June 1, 1955Publication History Published online1 May 2002Published inissue 1 June 1955https://pubs.acs.org/doi/10.1021/ja01617a001https://doi.org/10.1021/ja01617a001research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Molecular control of angiopoietin signalling (2011)

The angiopoietins act through the endothelial receptor tyrosine kinase Tie2 to regulate vessel maturation in angiogenesis and control quiescence and stability of established vessels. The activating ligand, Ang1 (angiopoietin-1), is constitutively expressed by perivascular cells, and the ability of endothelial cells to respond to the ligand is controlled at the level of the Ang1 receptor. This receptor interacts with the related protein Tie1 on the cell surface, and Tie1 inhibits Ang1 signalling through Tie2. The responsiveness of endothelium to Ang1 is determined by the relative levels of Tie2 and the inhibitory co-receptor Tie1 in the cells. Tie1 undergoes regulated ectodomain cleavage which is stimulated by a range of factors including VEGF (vascular endothelial growth factor), inflammatory cytokines and changes in shear stress. Ectodomain cleavage of Tie1 relieves inhibition of Tie2 and enhances Ang1 signalling. This mechanism regulates Ang1 signalling without requiring changes in the level of the ligand and allows Ang1 signalling to be co-ordinated with other signals in the cellular environment. Regulation of signalling at the level of receptor responsiveness may be an important adaptation in systems in which an activating ligand is normally present in excess or where the ligand provides a constitutive maintenance signal.
Femtosecond laser fabricated nanostructures in silica glass (2003)

A femtosecond laser beam focused inside fused silica and other glasses can modify the refractive index of the glass. Chemical etching and atomic-force microscope studies show that the modified region can have a sharp-tipped cone-shaped structure with a tip diameter as small as 100 nm. Placing the structure near the bottom surface of a silica glass sample and applying a selective chemical etch to the bottom surface produces clean, circular, submicrometer-diameter holes. Holes spaced as close to one another as 1.4 mm are demonstrated. © 2003 Optical Society of America OCIS codes: 320.7110, 140.3330, 140.3440.
Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells. (1989)

Lymphocytes isolated from human fetal liver and expanded in vitro in IL-2-containing media reveal the existence of CD4+ gamma, delta T cells. These cells display differential features of double-negative and CD8+ gamma, delta T cells as well as of CD4+ alpha, beta T cells. Thus, they failed to lyse targets in lectin-mediated killing assays and to perform classical helper functions. These results add new information necessary for a better understanding of the physiological role of the gamma, delta T cells.
Data-driven situation awareness algorithm for vehicle lane change (2016)

A good level of situation awareness is critical for vehicle lane change decision making. In this paper, a Data-Driven Situation Awareness (DDSA) algorithm is proposed for vehicle environment perception and projection using machine learning algorithms in conjunction with the concept of multiple models. Firstly, unsupervised learning (i.e., Fuzzy C-Mean Clustering (FCM)) is drawn to categorize the drivers' states into different clusters using three key features (i.e., velocity, relative velocity and distance) extracted from Intelligent Driver Model (IDM). Statistical analysis is conducted on each cluster to derive the acceleration distribution, resulting in different driving models. Secondly, supervised learning classification technique (i.e., Fuzzy k-NN) is applied to obtain the model/cluster of a given driving scenario. Using the derived model with the associated acceleration distribution, Kalman filter/prediction is applied to obtain vehicle states and their projection. The publicly available NGSIM dataset is used to validate the proposed DDSA algorithm. Experimental results show that the proposed DDSA algorithm obtains better filtering and projection accuracy in comparison with the Kalman filter without clustering.
Coherent Optical Techniques for Diagnostics of Retinal Blood Flow (1999)

Up to now, a variety of coherent optical techniques have been proposed and extensively studied for diagnostics of the retinal blood flow. These techniques are mainly based on dynamic laser light-scattering phenomena such as the laser Doppler effect and the laser speckle fluctuation. This paper reviews, first, spectral reflectance properties of the ocular fundus tissue layers and, then, principles of the techniques with the comparison of the Doppler and the speckle methods. Some physical phenomena are also discussed in the origin of the techniques such as heterodyne and homodyne beatings, and time-varying speckles. Developing processes of each technique are briefly outlined. Peculiarities of blood flow measurements at the retina are finally examined from the methodological point of view. © 1999 Society of Photo-Optical Instrumentation Engineers.
Cyclical strain increases monocyte chemotactic protein-1 secretion in human endothelial cells (1996)

The effects of mechanical strain on monocyte chemotactic protein-1 (MCP-1) secretion were examined on human endothelial cells (ECs) grown on a flexible membrane base. MCP-1 release into culture medium from strained ECs was demonstrated to be time and strain dose dependent. Northern blot analysis demonstrated a mainly serum-independent 1.8-fold induction of MCP-1 mRNA levels in ECs strained at 15 kPa compared with unstrained controls. ECs treated with actinomycin D abolished this strain-induced expression. Strained ECs at the periphery of wells showed higher MCP-1 gene expression than ECs at the center. Pretreatment of ECs with either cytochalasin D or phalloidin did not abolish strain-induced gene expression. ECs pretreated with stretch-activated ion channel blocker gadolinium or with ryanodine to deplete intracellular stored Ca2+ strongly inhibited the strain-induced MCP-1 levels. We conclude that 1) cyclical strain can modulate the secretion of MCP-1 in a dose-dependent manner, 2) strain-induced MCP-1 production is mediated by increasing MCP-1 mRNA levels via transcription, 3) cytoskeletal rearrangement is not essential for this strain-induced MCP-1 expression, and 4) both Ca2+ influx via stretch-activated ion channels and intracellular Ca2+ release contribute to the strain-induced effect. Such strain-induced MCP-1 secretion might contribute to the trapping of monocytes in the subendothelial space to initiate atherogenesis.
Transmission Dynamics and Control of Severe Acute Respiratory Syndrome (2003)

Severe acute respiratory syndrome (SARS) is a recently described illness of humans that has spread widely over the past 6 months. With the use of detailed epidemiologic data from Singapore and epidemic curves from other settings, we estimated the reproductive number for SARS in the absence of interventions and in the presence of control efforts. We estimate that a single infectious case of SARS will infect about three secondary cases in a population that has not yet instituted control measures. Public-health efforts to reduce transmission are expected to have a substantial impact on reducing the size of the epidemic.
Haworth Memorial Lecture. Synthesis of complex oligosaccharide chains of glycoproteins (1984)

H. Paulsen, Chem. Soc. Rev., 1984, 13, 15 DOI: 10.1039/CS9841300015
Service creation and execution domain concept for the intelligent network (2002)

The service creation and execution domain concept for INs (intelligent networks) is proposed. This concept defines the scope for interactions and accesses between services, functions, and data. Furthermore, the authors clarify the functional requirements for IN service creation and execution processes, as well as the roles of the proposed service creation and execution domain concept. A discussion is also presented of the hierarchical domain types in relation to the identified IN participants, and the general rules for the proposed domain concept are identified.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>