gebhart/patrepeval huggingface dataset:
Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts (2000)

Osteoclasts express the alphavbeta3 integrin, an adhesion receptor that has been implicated in bone resorption and that is therefore a potential therapeutic target. To assess the role of this heterodimer in skeletal development in vivo, we engineered mice in which the gene for the beta3 integrin subunit was deleted. Bone marrow macrophages derived from these mutants differentiate in vitro into numerous osteoclasts, thus establishing that alphavbeta3 is not necessary for osteoclast recruitment. Furthermore, the closely related integrin, alphavbeta5, does not substitute for alphavbeta3 during cytokine stimulation or authentic osteoclastogenesis. beta3 knockout mice, but not their heterozygous littermates, develop histologically and radiographically evident osteosclerosis with age. Despite their increased bone mass, beta3-null mice contain 3.5-fold more osteoclasts than do heterozygotes. These mutant osteoclasts are, however, dysfunctional, as evidenced by their reduced ability to resorb whale dentin in vitro and the significant hypocalcemia seen in the knockout mice. The resorptive defect in beta3-deficient osteoclasts may reflect absence of matrix-derived intracellular signals, since their cytoskeleton is distinctly abnormal and they fail to spread in vitro, to form actin rings ex vivo, or to form normal ruffled membranes in vivo. Thus, although it is not required for osteoclastogenesis, the integrin alphavbeta3 is essential for normal osteoclast function.
Tau binding to microtubules does not directly affect microtubule‐based vesicle motility (2007)

Tau protein is a major microtubule (MT)-associated brain protein enriched in axons. Multiple functional roles are proposed for tau protein, including MT stabilization, generation of cell processes, and targeting of phosphotransferases to MTs. Recently, experiments involving exogenous tau expression in cultured cells suggested a role for tau as a regulator of kinesin-1-based motility. Tau was proposed to inhibit attachment of kinesin-1 to MTs by competing for the kinesin-1 binding site. In this work, we evaluated effects of tau on fast axonal transport (FAT) by using vesicle motility assays in isolated squid axoplasm. Effects of recombinant tau constructs on both kinesin-1 and cytoplasmic dynein-dependent FAT rates were evaluated by video microscopy. Exogenous tau binding to endogenous squid MTs was evidenced by a dramatic change in individual MT morphologies. However, perfusion of tau at concentrations approximately 20-fold higher than physiological levels showed no effect on FAT. In contrast, perfusion of a cytoplasmic dynein-derived peptide that competes with kinesin-1 and cytoplasmic dynein binding to MTs in vitro rapidly inhibited FAT in both directions. Taken together, our results indicate that binding of tau to MTs does not directly affect kinesin-1- or cytoplasmic dynein-based motilities. In contrast, our results provide further evidence indicating that the functional binding sites for kinesin-1 and cytoplasmic dynein on MTs overlap.
Joint optimization of radio and computational resources for multicell mobile cloud computing (2014)

We consider a MIMO multicell system wherein several Mobile Users (MUs) ask for computation offloading to a common cloud server through their femto-access points. We formulate the computation offloading problem as a joint optimization of the radio resources??the transmit precoding matrices of the MUs??and the computational resources??the CPU cycles/second assigned by the cloud to each MU??in order to minimize the overall users' energy consumption while meeting the latency constraints imposed by the applications running on the MUs. The resulting optimization problem is nonconvex (in the objective function and the constraints), and there are constraints coupling all the optimization variables. To cope with the nonconvexity, we hinge on successive convex approximation techniques and propose an iterative algorithm converging to a local optimal solution of the original nonconvex problem. The algorithm is also suitable for a parallel implementation across the access point, with limited coordination/signaling with the cloud. Numerical results show that the proposed joint optimization yields significant energy savings with respect to more traditional schemes performing a separate optimization of the radio and computational resources.
cDNA sequence and deduced amino acid sequence of the precursor of the 37‐kDa inner envelope membrane polypeptide from spinach chloroplasts (1991)

We present the nucleotide sequence and the deduced amino acid sequence of a cDNA clone that encodes the entire precursor of the 37-kDa inner envelope membrane protein from spinach chloroplasts. The precursor protein consists of 344 amino acids (Mr 38,976). In vitro processing followed by radiosequence analysis of the in vitro transcribed and translated precursor protein revealed that its transit peptide consists of only 21 amino acid residues. The transit peptide has the potential to form an amphiphilic alpha-helix with a strong hydrophobic moment. It is speculated that this structural element represents an ancestral envelope-targeting domain. The in vitro synthesized precursor protein is directed to the chloroplasts and it is inserted into the envelope membrane in an ATP-dependent manner. The mature protein (323 amino acid residues, Mr 36,830) has a moderate hydrophobicity and contains only one membrane-spanning segment which is located at the C-terminus and possibly anchors the protein within the envelope membrane.
Multiplexing and double band filtering with common-multimode cavities (1990)

A novel multiplexing and double band filtering (DBF) method is established. DBF refers to two-port equipment which serves two transmit frequency channels simultaneously. The methods build on frequency-independent resonance modes, excited within a common multimode cavity (CMC), which are assigned to different channel filters. The design principles are presented for cylindrical CMCs by way of example. It is shown that combining CMCs with advanced coupling methods produces a multitude of new design variants. Initial experimental results are presented for a diplexer and DBF equipment that are both realized with only two double-dual TE/sub 112//TM/sub 110/ CMCs and a novel iris-providing four intercavity couplings-to perform two four-pole elliptic function filter responses.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Synthesis and Conductivity of Indium-Doped Tin Pyrophosphates (2007)

We have synthesized indium-doped tin pyrophosphates as high-temperature anhydrous proton conductors. The ratio of tin to indium was varied using two different synthetic methods. The first is a high-temperature reaction in which a paste containing the reactants in excess phosphoric acid was heated for various amounts of time at various temperatures. The second method is a solution precipitation procedure followed by calcination, which offers several advantages over traditional synthetic techniques. These advantages include better stoichiometric control, lower temperature requirements, and chemically uniform products. Several phosphate sources were investigated, including phosphoric acid, pyrophosphoric acid, and potassium pyrophosphate. The resulting indium-doped tin pyrophosphates had good proton conductivity over a wide temperature range with no humidification.
Nematic main-chain elastomers: Coupling and orientational behavior (2008)

We summarize investigations on four different nematic main-chain elastomer systems. In the first part, the synthetic approaches towards nematic elastomers with clearing temperatures suitable for mechanical investigations are described. In the second part, the coupling between the liquid crystalline order and the chain conformation is quantified by the Landau-de Gennes coefficient U . Comparing different types of elastomers shows that the coupling depends on the type of mesogens forming the polymer backbone, and on the elastic modulus of the polymer network. In the third part, we compare the orientation behavior of the different systems under strain.
<title>Method for extracting camera operations in order to describe subscenes in video sequences</title> (1994)

Numerous attempts have been made to detect scene changes in video sequences and to treat scenes as units, to allow handling of very large amounts of video data. But less attention has been given to the structure of scenes themselves. In this study, we define a `sub-scene' as a structural component of a scene in terms of camera operations. In other words, sub-scenes are subsets of scenes, and consist of successive frames in which the movements of the contents are almost identical. The advantage of sub-dividing scenes into sub-scenes is that it gives added power to description of objects and motion information. In order to describe sub-scenes, the estimation of camera operations need not be very accurate, but it must be resistant to noise. The technique proposed in this paper for extracting camera operations, which processes more than two frames at a time by using a 2D spatio-temporal image, meets the above requirement. It is also faster than conventional frame-by-frame analysis. The results of experiments indicate that the technique is both feasible and useful.
Inhibition of Protein Glycation by Skins and Seeds of the Muscadine Grape (2006)

The formation of advanced glycation end (AGE) products, mediated in part by oxidative processes, has been linked to the pathogenesis of diabetic complications. In this study, the effect of the seed and skin extracts of the muscadine grape on AGE product formation was examined. Seeds and skins were extracted (10% w/v) with 50% ethanol and incubated at 37°C with a solution containing 250 mM fructose and 10 mg/ml albumin in 200 mM potassium phosphate buffer, pH 7.4. After 4 days, fluorescence was measured at the wavelength pair of 370 and 440 nm as an index of the formation of AGE products. Both seed and skin extracts were found to be efficacious inhibitors of AGE product formation. A 1:300 dilution of the seed extract decreased fluorescence by approximately 90% while muscadine grape skin extract produced a 75 % lowering. This difference correlates with the greater antioxidant activity found in muscadine seeds in comparison to skins. The three major polyphenols in the seeds, gallic acid, catechin and epicatechin all decreased the AGE product related fluorescence by 85% at a concentration of 100 uM. These results suggest that consumption of the muscadine grape may provide beneficial, protective effects against the development of diabetic complications.
New iridoid glucosides from Harpagophytum procumbens DC. (1983)

Three new iridoid glucosides, 8-O-(p-coumaroyl)-harpagide, 6'-O-(p-coumaroyl)-procumbide and procumboside, have been isolated from the roots of Harpagophytum procumbens DC., together with three known iridoid glucosides, harpagide, harpagoside, and procumbide. Procumboside is a novel iridoid glucoside having an ether linkage between C-3 and C-6.
Alternating Copolymerization of Butadiene-1,3 with Acrylonitrile (Special Issue on Polimar Chemistry, VI) (1968)

This review deals with the alternating copolymerization of several kinds of binary monomers such as olefins, conjugated dienes and polar vinyl monomers using Lewis acid type catalyst.Mainly, alternating copolymerization of butadiene with acrylonitrile using the binary catalyst of organoaluminum compound and transition metal compound, and the feature of the physical properties of the copolymer will be described.We succeeded to prepare the new alternating copolymer of butadiene with acrylonitrile, which is superior in toughness, elasticity and oil resistance to conventional nitrile rubber.
Living cationic polymerization of vinyl monomers by organoaluminum halides. 4. Polymerization of isobutyl vinyl ether by ethylaluminum dichloride (EtAlCl2) in the presence of ether additives (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiving cationic polymerization of vinyl monomers by organoaluminum halides. 4. Polymerization of isobutyl vinyl ether by ethylaluminum dichloride (EtAlCl2) in the presence of ether additivesYasuhisa Kishimoto, Sadahito Aoshima, and Toshinobu HigashimuraCite this: Macromolecules 1989, 22, 10, 3877–3882Publication Date (Print):October 1, 1989Publication History Published online1 May 2002Published inissue 1 October 1989https://pubs.acs.org/doi/10.1021/ma00200a010https://doi.org/10.1021/ma00200a010research-articleACS PublicationsRequest reuse permissionsArticle Views558Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel solid state proton-conductors based on polymeric non-oxy acids. Final report (1992)

Objectives of this project were to prepare and characterize novel solid state proton-conductors and to evaluate these compounds as fuel cell electrolytes. The thrust was on the synthesis of new proton-conducting ``model`` and ``polymeric`` compounds, based on acid functions of the type (R{sub f}SO{sub 2}){sub 2}NH and (R{sub f}SO{sub 2}){sub 2}CH{sub 2} in appropriate fluorinated carbon structures, their physics-chemical characterization (Infra-red, Nuclear Magnetic Resonance, Differential Scanning Calorimetry, and X-ray Diffraction), and is pro. evaluation as candidate fuel cell electrolytes for use at elevated temperatures. This project consisted of four tasks (i) Synthesis of Proton-Conducting Polymer Electrolytes; (ii) Physical and Chemical Characterization of Proton-Conducting Polymer Electrolytes; (iii) Electrochemical Characterization of Proton-Conducting Polymer Electrolytes; and (iv) Evaluation of Proton-Conducting Polymer Electrolytes for Fuel Cells.
Plagiarizing Plants: Amino Sugars as a Class of Glycosidase Inhibitors (2007)

Many polyhydroxylated alkaloids from plants are specific inhibitors of glycosidases. Information about these has led to the development of a wide range of both naturally occurring and synthetic inhibitors which may be used for mechanistic studies and for the purification of these enzymes. Sugar lactones are starting materials for highly efficient syntheses of deoxymannojirimycin and deoxyfuconojirimycin and of a number of their iminoheptitol analogues. This has allowed an investigation of the relationship between mannosidase and fucosidase inhibition.
Concurrent and distributed programming using constraint logic programs (2004)

We describe a coordination language for high-level distributed programming. Its roots are in concurrent constraint programming where there is a shared constraint store and synchronization is achieved via constraint entailment. A system is modeled as: (a) a set of processes, and (b) a set of constraints which capture the concurrent behavior of the system. The key advantages are that (1) there is a clear separation of the concurrency and the functionality aspects of the system, (2) processes are coordinated explicitly by a declarative formalism, i.e. constraints, and (3) the processes-agents are programming language independent.
Regulation of Parathyroid Hormone Secretion* (1991)

Calcium is the most important physiological regulator of PTH secretion. Peak PTH secretion occurs at an intracellular calcium concentration of about 200 nM, regardless of the extracellular calcium concentration. We suggest, therefore, that intracellular calcium concentration is a regulator of PTH secretion that maintains calcium homeostasis. Other factors may be responsible for modulation of the intracellular calcium concentration, ultimately modulating PTH secretion. The "paradoxical" nature of the dependence of PTH secretion on the calcium concentration may be explained by considering PTH secretion to be unusual in a quantitative, rather than a qualitative, fashion. A possible mechanism for the control of PTH secretion by intracellular calcium, which involves calcium-activated potassium channels, is proposed. The parathyroid cell plasma membrane contains several sensors or channels by means of which the cell senses extracellular calcium. It is not clear whether these entities are coupled to each other or whether they function independently. Guanine nucleotide regulatory proteins are transducers of extracellular signals, including calcium. Several other second messengers that influence PTH secretion have also been described, but possible interactions between these messengers have not yet been determined.
DCSim: Design Analysis on Virtualization Data Center (2012)

Virtualization has become a core technique to support a data center, which usually consists of hardware, virtual machine(VM), and operating system(OS) etc. With virtualization, users can make good use of resources provided in a data center with resource protection and efficient hardware utilization. However, as data amount has increased very rapidly, many issues such as low power and resource sharing have become very critical. To resolved these issues, this paper presents a novel simulation environment based on a tiny OS, Hard Disk Drive (HDD), and Solid State Drive(SSD) to help users and designers understand a data center via simulation and analysis. Compared with the previous work, our tool can simulate and analyze homogeneous and heterogeneous systems with a multi-layer approach. Although each part of a data center has been studied by researchers, the analysis for data centers with multiple layers or heterogeneous devices is still an important issue. If programmers cannot analyze a data center, they are not easy to handle resources efficiently or understand cross-layer influence. They may encounter unpredictable challenges arising from the integration of various components. To address these challenges, programmer and system designer will be need thorough understanding of multi-layer heterogenous system. We propose a new simulation tool called Data Center Simulator(DCSim). We have used small-scale os and storage simulation to achieve multi-layer system simulation to help us to understand multi-layer heterogenous system. Therefore, programmer can simulate and analysis the system that we will analysis the parallel program and different storage deices on DCSim.
Improvement of Sensitivity in Long-Wavelength Range in Organic Thin-Film Solar Cell with Interpenetrating Semilayered Structure (2006)

Photovoltaic cells with interpenetrating interfaces between codeposited layers of small-molecular-weight materials and conducting polymer layers fabricated by the solvent corrosion method have been investigated. In order to improve photosensitivity in the long-wavelength range of the cells, the codeposited layers of C60:metal-free phthalocyanine (H2Pc) and C60:3,4,9,10-perylene tetracarboxylic bis-benzimidazole (PTCBI) have been fabricated instead of the monodeposited layer of C60. The short-circuit current under a white light and the energy conversion efficiency of the cell using the codeposited layer have been enhanced compared to the C60 monodeposited cell because of its high sensitivity in the long-wavelength range.
Low-Level Drug Release-Rate Testing of Ocular Implants Using USP Apparatus 4 Dissolution and HPLC End Analysis (2010)

o develop a method for the determination of drug-release rate in low-level ocular implants using USP Apparatus 4 dissolution and HPLC end analysis.
Bacterial Degradation of Quinoline and Derivatives—Pathways and Their Biocatalysts (1998)

A series of interesting enzymes were discovered during investigations on the degradation of quinoline by microorganisms. These include the molybdenum-containing hydroxylases that catalyze the transformation 1→2 and the unusual 2,4-dioxygenases that catalyze the reaction 3→4. The application of the hydroxylases may even be interesting in industry, because several quinoline derivatives are used as pharmaceuticals or agrochemicals.
Advances in Target Detection and Tracking in Forward-Looking InfraRed (FLIR) Imagery (2014)

Here we give context to the Special Issue on "Detection and Tracking of Targets in Forward-Looking InfraRed (FLIR) Imagery" in Sensors. We start with an introduction to the role of infrared images in today's vision-based applications, by outlining the specific challenges that characterize detection and tracking in FLIR images. We then illustrate why selected papers have been chosen to represent the domain of interest, by summarizing their main contributions to the state-of-the-art. Lastly, we sum up the main evidence found, and we underline some of the aspects that are worthy of further investigation in future research activities.
Application mapping in NoC-Based many-cores (2012)

Many-core platforms based on Network-on-Chip (NoC [Benini and De Micheli 2002]) present an emerging technology in the real-time embedded domain. Although the idea to group the applications previously executed on separated single-core devices, and accommodate them on an individual many-core chip offers various options for power savings, cost reductions and contributes to the overall system flexibility, its implementation is a non-trivial task. In this paper we address the issue of application mapping onto a NoCbased many-core platform when considering fundamentals and trends of current many-core operating systems, specifically, we elaborate on a limited migrative application model encompassing a message-passing paradigm as a communication primitive. As the main contribution, we formulate the problem of real-time application mapping, and propose a three-stage process to efficiently solve it. Through analysis it is assured that derived solutions guarantee the fulfilment of posed time constraints regarding worst-case communication latencies, and at the same time provide an environment to perform load balancing for e.g. thermal, energy, fault tolerance or performance reasons.We also propose several constraints regarding the topological structure of the application mapping, as well as the inter- and intra-application communication patterns, which efficiently solve the issues of pessimism and/or intractability when performing the analysis.