gebhart/patrepeval huggingface dataset:
1. Reservoir Management and Field Life Cycle (2010)

Elements of reservoir management have been practiced for years, particularly if a major expenditure was planned for a field. However, the formalism of reservoir management as a process is a relatively recent concept in the petroleum industry. Wiggins and Startzman (1990) define reservoir management as “that set of operations and decisions by which a reservoir is identified, measured, produced, developed, monitored and evaluated from its discovery through depletion and final abandonment.”
Colloidal lithography with crosslinkable particles: fabrication of hierarchical nanopore arrays (2005)

We demonstrate that colloidal lithography with self-assembled monolayers of crosslinkable polymeric particles can be used to create hierarchical arrays of nanopores on substrates.
Locating causes of program failures (2005)

Which is the defect that causes a software failure? By comparing the program states of a failing and a passing run, we can identify the state differences that cause the failure. However, these state differences can occur all over the program run. Therefore, we focus in space on those variables and values that are relevant for the failure, and in time on those moments where cause transitions occur---moments where new relevant variables begin being failure causes: "Initially, variable argc was 3; therefore, at shell_sort(), variable [2] was 0, and therefore, the program failed." In our evaluation, cause transitions locate the failure-inducing defect twice as well as the best methods known so far.
SUCCESSFUL ALLOGENEIC BONE MARROW TRANSPLANTATION IN A 2.5-YEAR-OLD BOY WITH ONGOING CYTOMEGALOVIRUS VIREMIA AND SEVERE APLASTIC ANEMIA AFTER ORTHOTOPIC LIVER TRANSPLANTATION FOR NON-A, NON-B, NON-C HEPATITIS (1997)

This case report shows that allogeneic bone marrow transplantation is feasible and well tolerated in a patient with severe aplastic anemia after liver transplantation for acute fulminant viral hepatitis.
The Development Role of the University of Norrland (1988)

Implementation analysis appears to promise that rare combination of rigorous methodology and social relevance often sought in policy analysis. In theory, implementation analysis seems to offer not simply evaluation techniques for the assessment of public program performance but also guidance, if not rules, for the successful attainment of policy objectives. In a seminal article, typical of the state of implementation analysis, Sabatier and Mazmanian (1979) ventured to state conditions for the accomplishing of policy objectives or ‘effective implementation’. Implementation analysis would, if its potential is realized, take policy analysis further than evaluation research (ER) or social impact analysis (SIA); contrary to the narrow focus of traditional public administration on program execution, implementation analysis would not only highlight the extent to which the policy objectives have been attained but also come up with directives for planners and policy makers as to how they should mould their program in order to achieve ‘effective implementation’. A warning against excessive optimism about implementation analysis may result in a realistic understanding of the difficulties involved, and may rescue the concept from the narrowly pessimistic notion that implementation analysis cannot be anything but evolution analysis.
Differential expression of ribosome‐inactivating protein genes during somatic embryogenesis in spinach (<i>Spinacia oleracea</i>) (2008)

Root segments from spinach (Spinacia oleracea L. cv. Jiromaru) seedlings form embryogenic callus (EC) that responded to exogenous GA(3) by accumulating a 31-kDa glycoprotein [BP31 or S. oleracea ribosome-inactivating protein (EC 3.2.2.22) (SoRIP1)] in association with the expression of embryogenic potential. Microsequencing of this protein revealed significant similarity with type 1 RIPs. We identified cDNAs for SoRIP1 and S. oleracea RIP2 (SoRIP2), a novel RIP having a consensus shiga/ricin toxic domain and performed a comparative analysis of the expression of SoRIPs during somatic embryogenesis. Western blotting and quantitative polymerase chain reaction analyses revealed that the expression of SoRIP1 in calli increased remarkably in association with the acquisition of embryogenic potential, although the expression in somatic embryos decreased moderately with their development. However, the expression of SoRIP2 in calli remained low and constant but increased markedly with the development of somatic embryos. Treatment of callus with GA(3) and/or ABA for 24 h, or with ABA for a longer period, failed to stimulate the expression of either gene. Immunohistochemistry showed that SoRIP1 preferentially accumulated in the proembryos and peripheral meristem of somatic embryos early in development. Appreciable expression of SoRIP2 was not detected in the callus, but intense expression was found in the epidermis of somatic embryos. These results suggest that the expression of spinach RIP genes is differentially regulated in a development-dependent fashion during somatic embryogenesis in spinach.
Synthesis of acrylamide/olefin copolymers by a diimine nickel catalyst (2000)

Nickel precursor [bis(N,N ′-dimesitylimino)acenaphthene]dibromonickel ((MesBIAN)NiBr2, 1) and MAO were used to catalyse the copolymerisation of acrylamide (AA) and ethylene (E) by passivating AA with triisobutylaluminium (TIBA), trimethylaluminium (TMA) or Et2AlCl (DEAC). The activity with TIBA is as high as 1.04×106 g/(mol Ni·[E]·h). Acrylamide-ethylene copolymerisation activity of 2.5×105 g/(mol Ni·[E]·h) was achieved using MgBu2/Et2AlCl as cocatalyst for 1 in the absence of MAO. Acrylamide was also terpolymerised with ethylene and propylene.
A 5 V-only virtual ground flash cell with an auxiliary gate for high density and high speed application (2002)

A 5 V-only virtual ground flash EEPROM cell with an auxiliary gate is proposed for high-density and high-speed application. The virtual ground auxiliary gate structure achieves a cell area of 2.59 mu m/sup 2/ with a 0.5- mu m technology and enables a fast programming of less than 1 mu s with a drain voltage of 5 V. It also provides a read-out current higher than 100 mu A and a soft-write lifetime greater than 10 years in read operation. The cell is suitable for high-density flash memories beyond 16 M bits.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Contact Allergy to Topical Corticosteroids: Update and Review on Cross- Sensitization (2009)

Contact allergy to topical corticosteroids (TCs) is an emerging problem, whose diagnosis can be complex owing to the peculiar characteristics of steroid allergens and the possible inadequacy of current diagnostic methods, including concentration and vehicle used in patch testing. The occurrence of cross-reactions among different TCs is not rare, but prediction of these is not sufficiently reliable. Moreover, the distinction between true cross-reactivity and concomitant sensitization may be difficult. The original classification proposed by Coopman et al. has been distinguished corticosteroids into four groups according to their molecular structure. These authors hypothesized that allergic contact reactions were more frequent with corticosteroids belonging to the same group. However, the clinical practice has evidenced that cross reactivity exists also among corticosteroids belonging to different groups. The potential to cross-react among corticosteroids is thought to be related not only to the structural homology but also to the stereoisomerism and metabolism of these drugs. Recent evidence suggests that mechanisms responsible for cross-reactivity may occur at T lymphocyte level during antigen presentation. Further investigations are needed to gain a more complete understanding of this important topic. This article also reviews some patents related to the treatment of contact dermatitis and other inflammatory skin diseases.
Nanoparticle-Assisted Transcutaneous Delivery of a Signal Transducer and Activator of Transcription 3-Inhibiting Peptide Ameliorates Psoriasis-like Skin Inflammation (2018)

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in psoriatic skin inflammation and acts as a key player in the pathogenesis and progression of this autoimmune disease. Although numerous inhibitors that intervene in STAT3-associated pathways have been tested, an effective, highly specific inhibitor of STAT3 has yet to be identified. Here, we evaluated the in vitro and in vivo biological activity and therapeutic efficacy of a high-affinity peptide specific for STAT3 (APTstat3) after topical treatment via intradermal and transcutaneous delivery. Using a preclinical model of psoriasis, we show that intradermal injection of APTstat3 tagged with a 9-arginine cell-penetrating peptide (APTstat3-9R) reduced disease progression and modulated psoriasis-related cytokine signaling through inhibition of STAT3 phosphorylation. Furthermore, by complexing APTstat3-9R with specific lipid formulations led to formation of discoidal lipid nanoparticles (DLNPs), we were able to achieve efficient skin penetration of the STAT3-inhibiting peptide after transcutaneous administration, thereby effectively inhibiting psoriatic skin inflammation. Collectively, these findings suggest that DLNP-assisted transcutaneous delivery of a STAT3-inhibiting peptide could be a promising strategy for treating psoriatic skin inflammation without causing adverse systemic events. Moreover, the DLNP system could be used for transdermal delivery of other therapeutic peptides.
Pruning Classification Rules with Instance Reduction Methods (2015)

Generating classification rules from data often leads to large sets of rules that need to be pruned. A new pre-pruning technique for rule induction is presented which applies instance reduction before rule induction. Training three rule classifiers on datasets that have been reduced earlier with instance reduction methods leads to a statistically significant lower number of generated rules, without adversely affecting the predictive performance. The search strategies used by the three algorithms vary in terms of both type (depth-first or beam search) and direction (general-to-specific or specific-to-general).
Electromechanical and physicochemical properties of connective tissue. (1983)

This review has dealt primarily with the electromechanical and transport properties of the extracellular matrix, which generally contains ionized charged groups under physiological conditions. Connective tissues are not electrically "active" in the sense of nerve or muscle; that is, electrical signals do not propagate as waves within the tissue. However, we have attempted to show the importance of "passive" electromechanical coupling and the coupling of passive transport mechanisms to the functional health of connective tissues. The effect of mechanical and electrical stresses on cell growth and biosynthesis is a relatively new and exciting area of research that should provide important clues concerning the interactions between cells and the extracellular matrix. While the role of cells in connective tissues is beyond the scope of this review, it is well known that environmental stresses have a direct effect on the structure and composition of connective tissues. Studies have shown that changes in the chemical and mechanical environment of cells can significantly alter cell synthesis of polysaccharide and protein components of the matrix. For example, Gillard et al. studied the glycosaminoglycan and collagen composition of the flexor digitorium profundus tendon of the rabbit. In regions where the tendon is subject to tensile forces, the tissue GAG content is approximately 0.2% of the dry weight, a value not unlike other tendons. However, in the small sesamoid region where the tendon hooks around the heel bone, the tendon is subjected to high compressional stresses. In this region, the GAG concentration is 15 to 20 times higher and the GAG composition is similar to that of articular cartilage. Gillard et al. found that manipulation of the tendon so as to release the compressional forces lead to a decrease in GAG content by more than 60%. Subsequent replacement of the tendon to its original position caused a concomitant increase in the GAG content. These results can be interpreted to be directly linked to the influence of mechanical forces on cell synthesis. The recent finding that cell synthesis is also affected by imposed electrical fields may suggest that electrical, mechanical and chemical signals are somehow interpreted by the cells along common pathways. The fact that electrical potentials are naturally produced near cells by deformation of the extracellular matrix provides additional support for such hypotheses.
Treatment With Gonadotrophin Releasing Hormone Analogue in Advanced Prostatic Cancer (1983)

No AccessJournal of Urology1 Nov 1983Treatment With Gonadotrophin Releasing Hormone Analogue in Advanced Prostatic Cancer J.H. Waxman, J.A.H. Wass, W.F. Hendry, H.N. Whitfield, G.M. Besser, J.S. Malpas, and R.T.B. Oliver J.H. WaxmanJ.H. Waxman More articles by this author , J.A.H. WassJ.A.H. Wass More articles by this author , W.F. HendryW.F. Hendry More articles by this author , H.N. WhitfieldH.N. Whitfield More articles by this author , G.M. BesserG.M. Besser More articles by this author , J.S. MalpasJ.S. Malpas More articles by this author , and R.T.B. OliverR.T.B. Oliver More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)51634-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Treatment With Gonadotrophin Releasing Hormone Analogue in Advanced Prostatic Cancer." The Journal of Urology, 130(5), p. 1019 © 1983 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 130 Issue 5 November 1983 Page: 1019 Advertisement Copyright & Permissions© 1983 by The American Urological Association Education and Research, Inc.Metrics Author Information J.H. Waxman More articles by this author J.A.H. Wass More articles by this author W.F. Hendry More articles by this author H.N. Whitfield More articles by this author G.M. Besser More articles by this author J.S. Malpas More articles by this author R.T.B. Oliver More articles by this author Expand All Advertisement PDF downloadLoading ...
Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: A randomized, double-blind six-week trial with eighteen-week extension (1999)

Dose-loading with HCQ increased the degree of response at 6 weeks in this group of patients with early, predominantly seronegative RA. Adverse GI events were dose related, while adverse ocular events were not.
Efficient Trajectory Pattern Mining for both Sparse and Dense Dataset (2010)

The comprehension of phenomena related to movementnot only of people and vehicles but also of animals and other moving objectshas always been a key issue in many areas of scientific investigation or social analysis. Many applications track the movement of mobile objects, using location-acquisition technologies such as Global Positioning System (GPS), Global System for Mobile Communications (GSM) etc., and it can be represented as sequences of time stamped locations. In this paper, we analyze the trajectories of moving vehicles and we develop an algorithm for mining the frequent patterns of Trajectory data. We use the extensions of sequential pattern mining to spatiotemporal annotated sequential patterns. The description of frequent behaviors in terms of both space (i.e., the regions of space visited during movements) and time (ie, the duration of movements). In this paper an efficient trajectory pattern mining is proposed by incorporating three key techniques. In this paper we have examined ways of partitioning data for trajectory pattern discovery. Our aim has been to identify methods that will enable efficient counting of frequent sets in cases where the data is much too large to be contained in primary memory, and also where the density of the data means that the number of candidates to be considered becomes very large. Our starting point was a method which makes use of an initial preprocessing of the data into a tree structure (the P-tree) which incorporates a partial counting of support totals
Tensile Bond Strength Between Aggregate and Cement Paste or Mortar (1963)

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I.—<i>Report on the Schizopods collected by Mr. George Murray, F.R.S., during the Cruise of the ‘Oceana’ in</i> 1898 (1905)

by comparisons of the contents of the different
Development of High-Definition TV Displays (1982)

Since 1970 NHK(Japan Broadcasting Corp.) has been progressing research and development on high-definition displays for a high-definition TV (HD-TV).
[Effectiveness of a lactobacillus vaccine on trichomonas infections in women. Preliminary results]. (1980)

This is the report on a multi-centre study of the treatment of 444 women with trichomoniasis vaginalis using Solcotrichovac, a vaccine containing at least 7 x 10(9) inactivated microorganisms of various strains of lactobacillus acidophilus in each 0.5 ml dose. One year after the first vaccination 427 of the patients (96.2%) were followed up, and 92.5% of them were found to be cured of clinical symptoms; the remaining 7.5% must be considered as not cured, as either the slide or the culture was positive. We are convinced by these results that vaccination with Solcotrichovac represents an enhancement of therapeutic opportunities for the treatment of trichomoniasis vaginalis.
Porous silicon microspheres: synthesis, characterization and application to photonic microcavities (2010)

Porous silicon microspheres have been synthesized by chemical vapour deposition of disilane gas. Their spectral signatures are similar to those of electrochemically grown porous silicon, in particular they yield photoluminescence and they show an oxidation behaviour upon their exposure to the open air. The particles are highly spherical and poly-disperse in size with diameters of approximately 0.5 to 5 micrometres, and they have a very smooth surface. Because of these reasons they work as optical microcavities with well defined resonating Mie modes. These modes have been identified in the near-infrared range. They blue-shift considerably whenever the microspheres are in contact with air because of the aforementioned oxidation process.
A validated facial grading scale: The future of facial ageing measurement tools? (2010)

Validated, standardized scales for measurement of ageing and response to cosmetic procedures are lacking. Numerous scales have been published and, while they allow intra-study comparisons, almost all remain non-validated, and their heterogeneity makes comparisons across studies impossible. A set of validated, objective, quantitative scales has been developed in association with experts from different specialties within aesthetic medicine. These scales allow evaluation of the key signs of ageing that cause individuals to seek cosmetic procedures. Each scale is a five-point photonumeric scale based on computer-simulated photographs incorporating each aspect to be evaluated in a stepwise manner. Validation studies show that these scales have good intra- and inter-rater reliability, with intra-class correlation coefficients generally in the range 0.85-0.95, and similar test-retest correlations.
Blowing the whistle (1999)

The public interest disclosure act may protect those who are willing to speak out against patient abuse
Sulfoquinones in the hydrolysis of aryl esters of o- and p-hydroxyarenesulfonic acids in alkaline aqueous solutions of dioxane (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfoquinones in the hydrolysis of aryl esters of o- and p-hydroxyarenesulfonic acids in alkaline aqueous solutions of dioxaneSergio Thea, Giorgio Cevasco, Giuseppe Guanti, Andrew Hopkins, Nasrin Kashefi-Naini, and Andrew WilliamsCite this: J. Org. Chem. 1985, 50, 12, 2158–2165Publication Date (Print):June 1, 1985Publication History Published online1 May 2002Published inissue 1 June 1985https://pubs.acs.org/doi/10.1021/jo00212a032https://doi.org/10.1021/jo00212a032research-articleACS PublicationsRequest reuse permissionsArticle Views670Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
AlMe<sub>3</sub>-Promoted Oxidative Cyclization of η<sup>2</sup>-Alkene and η<sup>2</sup>-Ketone on Nickel(0). Observation of Intermediate in Methyl Transfer Process (2005)

AlMe3 can promote the oxidative cyclization of eta2-alkene and eta2-ketone on nickel(0) to give an intriguing nickel-aluminum dinuclear complex having a bridging methyl group, which might be an intermediate for the nickel-catalyzed cycloisomerization of o-allylacetophenone or o-allylbenzophenone.
Improving system reliability with automatic fault tree generation (2002)

Usually, fault tree analyses are performed manually. They are based on documents that describe the system. Considerable knowledge, system insight, and overview is necessary to consider many failure modes, and dependencies between system components and their functionality at a time. Often, the behavior is too complicated to fully comprehend all possible failure consequences. Manual fault tree analysis is error-prone, costly and not necessarily complete. Formal risk analysis, an approach for automatically generating a fault tree from finite state machine-based descriptions of a system, is presented. The generated fault tree is complete with respect to all failures assumed possible. It is the basis for subsequent improvements of the system design and quantitative analysis of safety and liveness requirements in the presence of failures. A case study of formal risk analysis, the automatic generation of a fault tree for all sensor failures of a production cell's elevating rotary table, is discussed.
Fading statistics on an over-the-sea transhorizon link (2002)

A wideband experimental system designed to analyse an 11.647 GHz transhorizon channel subject to troposcatter and anomalous propagation conditions is described. The evolution of the channel during multipath fading condition is presented with the aid of the estimated channel impulse response. The fading statistics of wideband and narrow band signals for a period of 8 months is presented.
TECHNOLOGY IN TEACHER EDUCATION: PROGRESS ALONG THE CONTINUUM (2016)

Schools, colleges, and departments of education (SCDEs) may be placed along a continuum in their integration of technology. The 1995 Office of Technology Assessment (OTA) report, Teachers & Technology: Making the Connection, spoke to one end of the continuum when it raised two important points—that “technology is not central to the teacher preparation experience” and that “most technology instruction . . . is teaching about technology . . . not teaching with technology across the curriculum”.