gebhart/patrepeval huggingface dataset:
Iodinated Analogs of Trimetoquinol as Highly Potent and Selective β<sub>2</sub>-Adrenoceptor Ligands (1996)

A series of trimetoquinol (1, TMQ) analogs were designed and synthesized based on the lead compound 2, a diiodinated analog of trimetoquinol which exhibits improved selectivity for beta 2-versus beta 1-adrenoceptors (AR). To determine the influence of 1-benzyl substituents of trimetoquinol on beta 2-AR binding affinity and selectivity, we replaced and/or removed the 3'-, 4'-, and 5'-methoxy substituents of trimetoquinol. Replacement of the 4'-methoxy group of 2 with an amino (21c) or acetamido (15) moiety did not significantly alter beta 2-AR and thromboxane A2/prostaglandin H2 (TP) receptor affinity. Substitution with a 4'-hydroxy (18) or -iodo (21b) group did not significantly alter beta 2-AR affinity, but greatly reduced TP receptor affinity (380- and 1200-fold, respectively). Further, the beta 2-AR can accommodate larger substituents such as a benzamide at the 4'-position (26b). Other monoiodo derivatives (24, 26a) have similar or slightly lower affinity to both beta 2-AR and TP receptor compared to their diiodo analogs. Interestingly, removal of the 4'-substituent of 3',5'-diiodo analogs increased beta 2-AR affinity with little or no effect on beta 1-AR and TP binding. Thus, analog 21a displayed highly potent (pKi 9.52) and selective (beta 2/beta 1 = 600) binding affinity for beta 2-AR. On the other hand, trifluoromethyl substituents at the 3'- and 5'-positions (27) essentially abolished binding affinity at beta 2-AR and TP receptors. The differential binding effects of the aforementioned trimetoquinol modifications on the receptor systems may reflect differences in the binding pocket that interacts with the benzyl portion of trimetoquinol analogs. Thus, manipulation of the 1-benzyl moiety of trimetoquinol (1) has resulted in analogs that exhibit potent beta 2-AR binding affinity and significantly lower beta 1-AR and TP receptor affinities.
The effects of saline or albumin resuscitation on acid-base status and serum electrolytes* (2006)

When comparing albumin and saline, the choice and amount of resuscitation fluid are independent predictors of acid-base status and serum electrolytes. When large volumes are given, albumin administration leads to a higher chloride concentration. However, overall differences between the types of fluid are minor, whereas the volume of fluid administered is a much stronger predictor of such changes, which are also influenced by illness severity and the passage of time.
Life, service and the cost of service of farm machines on 400 Iowa farms (1941)

That farmers of Iowa make an extensive use of farm machines is indicated by the 16th Census of the United States which gives the value of farm implements and machinery on Iowa farms, April 1, 1940, as $242,047,158. This is about one-twelfth of the total for the United States and represents an investment of $1,134 for each Iowa farm. Under these circumstances it is recognized that the use of farm machines occupies an important role in the agricultural practices of the state. Farm machines not only give the farm workers control over large units of power, thus making possible large individual productive capacity, but they also make farm labor less arduous. For these reasons the cost of farm-machine service or use as discussed in this bulletin should be of general interest.
Realization and Dissemination of the Second (1986)

The PTB work in the field of primary time and frequency standards is described. The dissemination of the PTB time scales via DCF 77, Loran-C and GPS is discussed.
Hybrid electro-optic polymer and selectively buried sol-gel waveguides (2003)

An approach to utilizing electro-optically (EO) active polymers in hybrid waveguide structures is described and demonstrated. Buried sol-gel waveguides provide a robust basis for planar integrated circuitry, suitable for coupling with optical fibers. By selectively exposing the core of a buried channel guide, overcoating with an EO polymer, and using appropriately tapered transition zones, a guided mode can be made to undergo adiabatic transitions from sol-gel waveguide up into the EO polymer and back. Such a single-mode device was constructed. These transitions were proven via modulation of the emerging wave’s polarization ellipse by application of voltage to the EO polymer.
Direct Activation of Mitochondrial Apoptosis Machinery by c-Jun N-terminal Kinase in Adult Cardiac Myocytes (2002)

Although oxidative stress causes activation of c-Jun N-terminal kinase (JNK) and apoptosis in many cell types, how the JNK pathway is connected to the apoptosis pathway is unclear. The molecular mechanism of JNK-mediated apoptosis was investigated in adult rat cardiac myocytes in culture as a model system that is sensitive to oxidative stress. Oxidative stress caused JNK activation, cytochrome c release, and apoptosis without new protein synthesis. Oxidative stress-induced apoptosis was abrogated by dominant negative stress-activated protein kinase/extracellular signal-regulated kinase kinase-1 (SEK1)-mediated inhibition of the JNK pathway, whereas activation of the JNK pathway by constitutively active SEK1 was sufficient to cause apoptosis. Inhibition of caspase-9, an apical caspase in the mitochondrial apoptosis pathway, suppressed oxidative stress-induced apoptosis, whereas inhibition of caspase-8 had no effect, indicating that both the JNK pathway and the mitochondrial apoptosis machinery are central to oxidative stress-induced apoptosis. Both JNK and SEK1 localized on mitochondria where JNK was activated by oxidative stress. Furthermore, active JNK caused the release of apoptogenic factors such as cytochrome c from isolated mitochondria in a cell-free assay. These findings indicate that the JNK pathway is a direct activator of mitochondrial death machinery without other cellular components and provide a molecular linkage from oxidative stress to the mitochondrial apoptosis machinery.
On the Role of Calpain and Rho Proteins in Regulating Integrin-induced Signaling (1999)

Integrin-induced adhesion of cells activates intracellular signaling pathways that lead to cytoskeletal reorganizations and altered cell behavior. One of the signaling molecules that is activated as a consequence of integrin-induced signaling is calpain. Much of the understanding of calpain's importance in signaling has come from the study of platelets. Studies on platelets have demonstrated that the major substrates for calpain are proteins present in the complexes of integrin, cytoskeletal proteins, and signaling molecules that form as a consequence of integrin engagement. We have now shown that calpain is also active in cultured adherent cells and that the calpain-induced cleavage of proteins in these cells is required for integrin-induced changes in cell morphology and spreading. Investigation of the mechanisms involved has revealed that calpain induces integrin-induced formation of focal adhesions and actin filament reorganizations and that it does so by inducing the activation of both Rac1 and RhoA.
Enzymes of Phosphatidylcholine Synthesis in <i>Lemna</i>, Soybean, and Carrot (1988)

Cell-free extracts from Lemna and suspension cultured carrot (Daucus Carota L.) catalyze S-adenosylmethionine-dependent N-methylations of phosphoethanolamine, phosphomethylethanolamine, and phosphodimethylethanolamine; extracts of suspension cultured soybean (Glycine max), of phosphoethanolamine only. Material pelleted from each tissue between 15,000 and 100,000g catalyzes S-adenosylmethionine-dependent N-methylations of phosphatidylmethylethanolamine and phosphatidyl-dimethylethanolamine, but not phosphatidylethanolamine. Extracts from each tissue catalyze CTP-dependent cytidylyltransfers to each of the three methylated phosphoethanolamine derivatives, forming the corresponding CDP derivatives. Some of the properties of the activities investigated are reported. On the basis of in vivo labeling experiments, we have proposed (AH Datko, SH Mudd 1988 Plant Physiol 88: 854-861) differing pathways for phosphatidylcholine synthesis in which, after a common committing step, N-methylation of phosphoethanolamine, subsequent methylations occur in Lemna almost exclusively at the phospho-base level; in soybean, at the phosphatidyl-base level; and in carrot, at both levels. Thus, among the activities investigated, at least those required for the operation of the proposed pathways have been positively demonstrated. The extent to which the present results explain the differences between these pathways is discussed, and a speculation offered as to how these differences may have arisen phylogenetically.
Automated example oriented REST API documentation at Cisco (2017)

Generating and maintaining an up-to-date API documentation is a challenging problem for evolving REST APIs. At Cisco, we've used SpyREST, an automated REST API documentation tool, via our functional tests to solve this problem with one of our APIs for a cyber security application over the past eighteen months. Using this approach, we've avoided the need for extensive manual effort by leveraging our test code to also generate a continuously updated API documentation as the API evolved. Our always-updated API documentation has helped creating a fast feedback loop between the developers and QA engineers. The findings from this paper can be used by practitioners to introduce automation to reduce the manual effort associated to their REST API documentation process.
Digital high-resolution high-performance CCD camera with 2048 x 2048 pixels for dynamic applications (1997)

A modular, multi-channel digital camera system has been designed.It provides a platform for the investigation of high-speed, high-resolution CCD sensors that are suited for dynamic medical x-ray imaging. The system supports frame rates from 30 frames per second (fps) for images with 1024 X 1024 pixels and 6-8 fps for images with 2048 X 2048 pixels. The complete system comprises camera head and correction circuits and yields a consecutive output stream of data. The camera electronics permits the testing of sensors with up to four parallel readout channels. It offers a variable bandwidth of up to 25 MHz per channel with a digitization resolution of 12 bits. The modulatory and programmability allow the adaptation of the camera system to a wide range of interesting applications. The camera electronics consists of a majority of sensor independent and a relatively small section of sensor dependent components. A detailed description of the camera, methods for performance analysis, measurement results, images, and a noise analysis are presented and discussed. As an example, linearity, MTF and noise of the camera system equipped with the FTF2020, a 2k X 2k CCD sensor from Phillips Professional Imaging have ben measured. The noise contains fixed pattern and random components. The developed camera architecture is capable of fulfilling the high requirements of dynamic, high-resolution medical imaging.
Applications of Hydrogen Flux Monitoring to Pre-Weld Bakeouts of Steel (2004)

Abstract During a pre-weld bakeout, hydrogen efflux was monitored in real time using the hydrogen collection method at high temperatures. A circular section of a 50 mm thickness alkylation unit acid storage vessel dome which had developed severe hydrogen blistering was removed, and pre-weld bake-out applied using heat pads placed within twelve inches of the cut-away section perimeter, on the dome’s exterior face. A ring of eight hydrogen collection probes were placed under the heat pads, about six inches from the cut-away perimeter. One probe became blocked and failed to deliver measurement. The remaining seven delivered flux values indicating effective bake-out at five sites, and the need for extended bake-out at two neighbouring sites. The efflux trend at these sites strongly indicated initially high concentrations of hydrogen liberated by the bake-out. Corresponding efflux measurements at corresponding positions on the dome’s interior face were much lower. A model of hydrogen diffusion for the bake-out, incorporating a high density of trapping sites located at depths of 5-15 mm beneath the monitored exterior face provided model flux transients consistent with field flux transients and spot measurements. The work demonstrated that pre-weld heat treatment can be assessed, extended or reduced in real time, on evidence provided by spot high temperature hydrogen efflux measurements at a small number of sites. An additional bake-out is presented in which near zero hydrogen effluxed.
Subcellular Compartmentation of Uridine Nucleotides and Nucleoside-5′ -Diphosphate Kinase in Leaves (1990)

The subcellular compartmentation of nucleoside diphosphate kinase (EC 2.7.4.6) and the uridine nucleotides has been studied in leaves. Membrane filtration of barley (Hordeum vulgare L.) leaf mesophyll protoplasts and differential centrifugation of spinach (Spinacia oleracea L.) leaf extracts showed that about half the nucleoside diphosphate kinase is present in the cytosol. The activity is adequate to account for the turnover of UTP and UDP during photosynthetic sucrose synthesis. Nonaqueous density gradient centrifugation of freeze-stopped, lyophilized spinach leaf material showed that the uridine nucleotides are predominantly located in the cytosol and that the cytosolic UDP-glucose pool is considerably larger than the UTP or UDP pools.
Effect of off-axis implant on the characteristics of advanced self-aligned bipolar transistors (1987)

This letter discusses the effect of off-axis implant on the characteristics of advanced self-aligned bipolar transistors utilizing a sidewall-spacer technology. Experimental results are presented to show that as a result of offsetting the base profile with respect to the emitter profile due to the sidewall shadowing effect, the 7° off-axis implant causes orientation-dependent perimeter punchthrough at one of the emitter edges and orientation-dependent perimeter tunneling at the other emitter edge.
Ecient Regression Tests for Database Applications (2005)

If you browse through the articles of www.junit.org, you will find only one article that contains the word database in its abstract. This observation is shocking because, of course, testing is just as important for database applications as for any other application. The sad truth is that JUnit simply does not work for database applications, and there are no alternatives on the market place. The reason is that there are some fundamental issues in automatizing regression tests for database applications. This paper addresses one particular issue that arises from the fact that you change the state of a database application while you test it.
The structure of bis(dimethylamino)silane in the gas phase, determined by electron diffraction (1987)

We have studied the molecular structure of bis(dimethylamino)silane in the gas phase by electron diffraction. The molecule has no symmetry, the two dimethylamino groups having different CNC angles and conformations. Both nitrogens are non-planar, with the methyl groups displaced away from the other nitrogen in one case, towards it in the other case. The major structural parameters are r(SiN) 170.8 pm (both assumed equal), r(CN) 146.0 pm (all four assumed equal), and NSiN angle 112°. The asymmetry does not produce observable effects in the vibrational spectra, probably because the effects of coupling between dimethylamino groups are larger than any frequency differences due to the inequivalence. The vibrational spectra of the annealed solid are very similar to the i.r. spectrum of the gas, showing that no specific intermolecular association occurs on crystallisation.
ABSTRACT: Oil and Shale Gas from the Barnett Shale, Ft. Worth Basin, Texas (2001)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Floating gate MOSFET with reduced programming voltage (1994)

A floating gate MOSFET has been designed to minimise the tunnelling current density injected through the oxide between two polysilicon layers by using local field enhancement provided from a bump structure. Compared to the floating gate device introduced by Thomsen, the modified floating gate which is fabricated in the same standard 2 µm double-polysilicon CMOS technology, reduces the programming voltage by 2.4 V and the erasing voltage by 1.4 V.
Isotropic Coordinates, Circularity, and Bezout Numbers: Planar Kinematics From a New Perspective (1996)

Abstract It is commonly recognized that a convenient formulation for problems in planar kinematics is obtained by considering links to be vectors in the complex plane. However, scant attention has been paid to the natural interpretation of complex vectors as isotropic coordinates. These coordinates, often considered a special trick for analyzing four-bar motion, are in fact uniquely suited to two new techniques for analyzing polynomial systems: the BKK bound and the product-decomposition bound. From this synergistic viewpoint, a fundamental formulation of planar kinematics is developed and used to prove several new results, mostly concerning the degree and circularity of the motion of planar linkages. Useful for both analysis and synthesis of mechanisms, the approach both simplifies theoretical proofs and facilitates the numerical solution of mechanism problems.
Optical Quality and Intraocular Scattering in the Diabetic Eye without Diabetic Retinopathy (2019)

This pilot study suggests that optical quality was reduced, and intraocular scattering increased in the diabetic eye without diabetic retinopathy compared with controls.
Influence of Balloon Pressure During Stent Placement in Native Coronary Arteries on Early and Late Angiographic and Clinical Outcome (1999)

The systematic use of high-balloon-pressure inflation (15 to 20 atm) during coronary stent placement is not associated with any significant influence on the 1-year outcome of patients undergoing this intervention.
Edible Packaging Films Based on Fish Myofibrillar Proteins: Formulation and Functional Properties (1995)

ABSTRACT Biopackaging materials based on fish myofibrillar proteins have been developed. The effects of protein concentration, pH, temperature and storage time before casting on the apparent viscosity of the film forming solution (FFS) were evaluated using experimental design methodology. The first objective was to determine a feasible experimental range for film‐forming. The pH and protein concentration had strong interactive effects on FFS viscosity. During FFS storage before casting, partial degradation of high molecular weight protein components led to decreased viscosity, allowing thin layer casting. In the experimental range for film‐forming, none of the conditions affected film functional properties. Standard conditions were determined at: pH 3.0, 2.0g protein/100g FFS, 25°C and 6 hr storage. The functional properties of the standard biopackaging were slightly better than those that determined for known protein‐based films, with tensile strength close to those of low density polyethylene films.
Platelets Present Antigen in the Context of MHC Class I (2012)

Platelets are most recognized for their vital role as the cellular mediator of thrombosis, but platelets also have important immune functions. Platelets initiate and sustain vascular inflammation in many disease conditions, including arthritis, atherosclerosis, transplant rejection, and severe malaria. We now demonstrate that platelets express T cell costimulatory molecules, process and present Ag in MHC class I, and directly activate naive T cells in a platelet MHC class I-dependent manner. Using an experimental cerebral malaria mouse model, we also demonstrate that platelets present pathogen-derived Ag to promote T cell responses in vivo, and that platelets can be used in a cell-based vaccine model to induce protective immune responses. Our study demonstrates a novel Ag presentation role for platelets.
Isolation and characterization of protein A24, a "histone-like" non-histone chromosomal protein. (1975)

In earlier studies, the nucleolar levels of protein A24 were found to be markedly decreased in the nucleolar hypertrophy induced by thioacetamide or during liver regeneration (Ballal, N.R., Goldknopf, I.L., Goldberg, D.A., and Busch, H. (1974) Life Sci. 14, 1835-1845; Ballal, N.R., Kang, Y.-J., Olson, M.O.-J., and Busch, H.J. Biol. Chem. 250, 5921-5925). To determine the role of protein A24, methods were developed for its isolation in highly purified form. Milligram quantities of highly purified protein A24 were isolated from the 0.4 N H2SO4-soluble proteins of calf thymus chromatin by exclusion chromatography on Sephadex G-100, followed by preparative polyacrylamide gel electrophoresis. Protein A24 was highly purified as shown by its migration as a single spot on two-dimensional polyacrylamide gel electrophoresis, its single NH2-terminal amino acid, methionine, and the production of approximately 50 peptides by tryptic digestion. Like histones 2A, 2B, 3, and 4. A24 was extractable from chromatin with 0.4 N H2SO4 or 3 M NaCl/7 M urea, but unlike most non-histone proteins or histone 1, protein A24 was not extracted with 0.35 M NaCl, 0.5 M HClO4, or 0.6 M NaCl. Protein A24 was present in only 1.9% of the total amount of histones 2A, 2B, 3 and 4; its molecular weight is 27,000.
Finding Emotion from Multi-lingual Voice Data (2020)

Human-Machine interaction through audio or speech is always challenging because of the difficulties in emotion detection from audio data. Emotion is a natural way to express the individual's mental state. When a person is in an unusual mental state, the voice changes accordingly in his or her subconsciousness. Emotion detection from continuous speech with multi-lingual platform is more difficult due to complicated feature extraction and feature modeling process. Voice features change due to physical, background and channel noise or sue to other articulatory obstacles. In spite of all these uncertainties, researchers find that among glottal wave forms (consists of glottal excitation and vocal tract filters), glottal pulses carry basic information of voice because these pulses are out of articulatory effects or inner-mouth changes. In this research, we capture real-time speech signal, separate the glottal pulses and buffer the signal into specified frames to identify the phonemes those are affected mostly in emotionally unstable conditions. In these frames, we identify the basic voice controlling features like pitch, intensity, jitter to get these phonemes. For this scheme, we use a real-life continuous dataset which is a multilingual corpus of emotional speech. After feature extraction from the dataset, different classification methodologies have been applied to predict the emotional state and we find our prediction model with around 83% accuracy.
Expression of pertussis toxin in Bordetella bronchiseptica and Bordetella parapertussis carrying recombinant plasmids (1989)

Pertussis toxin is produced only by strains of Bordetella pertussis. Cloned genes encoding pertussis toxin from B. pertussis were transferred into Bordetella bronchiseptica and Bordetella parapertussis by conjugation. These transconjugants expressed pertussis toxin at levels comparable to those expressed by B. pertussis. The toxin made by these strains was biologically active in the Chinese hamster cell clumping assay, contained all five subunits, and was mostly periplasmic. Toxin expression appeared to be modulated in the same way as are the vir-regulated genes of B. pertussis. Introduction of these plasmids into B. pertussis failed to produce hypertoxigenic strains. Instead, these transconjugants underwent plasmid loss, gene deletions, or conversion to the avirulent phase.