gebhart/patrepeval huggingface dataset:
Phospholipid scramblase 3 is the mitochondrial target of protein kinase C delta-induced apoptosis. (2003)

Protein kinase C (PKC) delta translocates to mitochondria during apo-ptosis,but its mitochondrial target remains unclear. We found that PKC-delta physically interacted with and phosphorylated phospholipid scramblase 3 (PLS3) after UV irradiation. PLS3 is a high-affinity substrate for PKC-delta in vitro with the K(m) at 10.5 nM. Cells expressing wild-type PLS3 became apoptotic on phorbol ester stimulation, whereas the control cells did not. Expression of a mitochondrial-targeted PKC-delta enhanced apoptosis more prominently in HeLa-PLS3 cells than control HeLa cells and HeLa cells expressing an inactive PLS3 mutant. These results indicate that PLS3 is a downstream effector of PKC-delta in the mitochondria.
Magnetic photonic band-gap material at microwave frequencies based on ferromagnetic nanowires (2003)

We present an experimental investigation of a class of microwave photonic band-gap (PBG) materials, in which the magnetic permeability μ varies periodically within the material. This material is fabricated using a periodic arrangement of arrays of magnetic nanowires. As for dielectric or metallic PBG, the band-gap behavior varies with the geometrical parameters fixing the spatial periodicity of the magnetic structure. The magnetic photonic band gap is induced by the presence of a ferromagnetic resonance effect in the vicinity of the band gap.
Acute Effects of Radiofrequency Ablation upon Atrial Conduction in Proximity to the Lesion Site (1998)

The electrophysiological effects of RF ablation upon the areas in proximity to the lesioned zones have not yet been well characterized. An experimental model is used to investigate atrial conduction in the boundaries of RF damaged zones. In 11 isolated and perfused rabbit hearts, endocardial atrial electrograms were recorded using an 80-lead multiple electrode positioned in the left atrium. Both before and after the RF application (5 W, 8 s, 1-mm diameter unipolar epicardial electrode) in the mid-portion of the free left atrial wall, measurements were made of conduction time from the pacing zone (posterior wall of the left atrium) to three points between 7.5 and 7.9 mm distal to the damaged zone. Conduction velocity and the direction of the activation propagation vector were determined in ten groups of four electrodes positioned around the damaged zone, and at the left atrial appendage. The mean diameter (+/- SEM) of the transmural lesions produced by RF ablation and defined by macroscopic examination was 4.2 +/- 0.2 mm. The conduction times to the three points distal to the lesion site were significantly prolonged as a result of RF ablation; 7.6 +/- 0.4, 7.4 +/- 0.5, and 6.9 +/- 1.0 ms (control); and 11.3 +/- 1.0 (P < or = 0.01), 11.1 +/- 1.3 (P < 0.01), 10.6 +/- 1.4 ms (P < 0.05) (post-RF). The differences between the conduction velocities determined in the areas surrounding the lesion, before and after RF application, failed to reach statistical significance: 86.2 +/- 6.5 cm/s (control) versus 75.5 +/- 5.7 cm/s (post-RF) (NS). After RF, significant variations were only observed in the direction of impulse propagation in the proximal-inferior quadrant adjacent to the lesion site, the difference being -61 degrees +/- 18 degrees (P < 0.02). In 2 of 4 experiments in which the lesion size was increased by a second RF application (5 W, 16 s), tachycardias with activation sequence around the lesion could be induced, with cycle lengths of 56 and 50 ms, respectively. In the atrial wall, the conduction times to the regions distal to the RF lesion are significantly prolonged. No significant changes are observed in conduction velocity in the areas in proximity to the lesion. Prolonged conduction to the areas distal to the ablation site is due to the lengthened pathway traveled by the impulses in reaching these areas. Tachycardias with activation patterns that suggest reentry around the RF damaged zone may be induced.
Synthesis and Reactions of Molybdenum Triamidoamine Complexes Containing Hexaisopropylterphenyl Substituents (2003)

We have synthesized a triamidoamine ligand ([(RNCH(2)CH(2))(3)N](3)(-)) in which R is 3,5-(2,4,6-i-Pr(3)C(6)H(2))(2)C(6)H(3) (hexaisopropylterphenyl or HIPT). The reaction between MoCl(4)(THF)(2) and H(3)[HIPTN(3)N] in THF followed by 3.1 equiv of LiN(SiMe(3))(2) led to formation of orange [HIPTN(3)N]MoCl. Reduction of MoCl (Mo = [HIPTN(3)N]Mo) with magnesium in THF under dinitrogen led to formation of salts that contain the ((Mo(N(2)))(-) ion. The (Mo(N(2)))(-) ion can be oxidized by zinc chloride to give Mo(N(2)) or protonated to give MoN=NH. The latter was found to decompose to yield MoH. Other relevant compounds that have been prepared include (Mo=N-NH(2))(+) (by protonation of MoN=NH), M=1;N, (Mo=NH)(+) (by protonation of M=N), and (Mo(NH(3)))(+) (by treating MoCl with ammonia). (The anion is usually (B(3,5-(CF(3))(2)C(6)H(3))(4))(-) = (BAr'(4))(-).) X-ray studies were carried out on (Mg(DME)(3))(0.5)[Mo(N(2))], MoN=NMgBr(THF)(3), Mo(N(2)), M=N, and (Mo(NH(3)))(BAr'(4)). These studies suggest that the HIPT substituent on the triamidoamine ligand creates a cavity that stabilizes a variety of complexes that might be encountered in a hypothetical Chatt-like dinitrogen reduction scheme, perhaps largely by protecting against bimolecular decomposition reactions.
Evasion-resistant malware signature based on profiling kernel data structure objects (2012)

Malware authors attempt in an endless effort to find new methods to evade the malware detection engines. A popular method is the use of obfuscation technologies that change the syntax of malicious code while preserving the execution semantics. This leads to the evasion of signatures that are built based on the code syntax. In this paper, we propose a novel approach to develop an evasion-resistant malware signature. This signature is based on the malware's execution profiles extracted from kernel data structure objects and neither uses malicious code syntax specific information code execution flow information. Thus, proposed signature is more resistant to obfuscation methods and resilient in detecting malicious code variants. To evaluate the effectiveness of the proposed approach, a prototype signature generation tool called SigGENE is developed. The effectiveness of signatures generated by SigGENE evaluated using an experimental root kit-simulation tool that employs techniques commonly found in rootkits. This simulationtool is obfuscated using several different methods. In further experiments, real-world malware samples that have different variants with the same behavior used to verify the real-world applicability of the approach. The experiments show that the proposed approach is effective, not only in generating a signature that detects the malware and its variants and defeats different obfuscation methods, but also, in producing an execution profiles that can be used to characterize different malicious attacks.
The essential 65-kilodalton DNA-binding protein of herpes simplex virus stimulates the virus-encoded DNA polymerase (1989)

The 65-kilodalton DNA-binding protein (65KDBP) of herpes simplex virus type 1 (HSV-1), the product of the UL42 gene, is required for DNA replication both in vitro and in vivo, yet its actual function is unknown. By two independent methods, it was shown that the 65KDBP stimulates the activity of the HSV-1-encoded DNA polymerase (Pol). When Pol, purified from HSV-1-infected cells, was separated from the 65KDBP, much of its activity was lost. However, addition of the 65KDBP, purified from infected cells, stimulated the activity of Pol 4- to 10-fold. The ability of a monoclonal antibody to the 65KDBP to remove the Pol-stimulating activity from preparations of the 65KDBP confirmed that the activity was not due to a trace contaminant. Furthermore, the 65KDBP did not stimulate the activity of other DNA polymerases derived from T4, T7, or Escherichia coli. The 65KDBP gene transcribed in vitro from cloned DNA and translated in vitro in rabbit reticulocyte lysates also was capable of stimulating the product of the pol gene when the RNAs were cotranslated. The product of a mutant 65KDBP gene missing the carboxy-terminal 28 amino acids exhibited wild-type levels of Pol stimulation, while the products of two large deletion mutants of the gene could not stimulate Pol activity. These experiments suggest that the 65KDBP may be an accessory protein for the HSV-1 Pol.
Rare concurrent infection with scrub typhus, dengue and malaria in a young female (2014)

Tropical infections due to dengue, malaria, leptospira, scrub typhus and many other vector borne diseases are commonly seen in South Asia including Indian subcontinent. These infections have overlapping clinical manifestations and season of presentation. Scrub typhus or tsutsugamushi disease is a febrile illness caused by bacteria Orientia tsutsugamushi of the family Rickettsia. It is being reported from all parts of the Indian subcontinent though it is more prevalent in sub-Himalayan regions of north India 1–2 . Malaria is highly endemic in India 3 . Dengue is prevalent throughout India and outbreaks of dengue have been seen from months of October to December 4 . Although concurrent infections are reported, they are not very common 5–6 . These infections being vector borne diseases, the reason for simultaneous infection can be the same breeding period of the vectors in post-monsoon season. Diagnosis of concurrent infections becomes difficult for a physician leading to delay in institution of appropriate treatment. We hereby report a rare case of a patient having concurrent infection with dengue, malaria and scrub typhus. Case report A 25-yr old female presented with complaints of high grade fever associated with chills and rigors of seven days duration during post-monsoon season. She also complained of headache and generalized myalgias. She noticed yellowish discolouration of eyes and reported progressively worsening shortness of breath over three days before admission to the hospital. Investigations done in outside hospital revealed anaemia with thrombocytopenia. Peripheral blood smear showed asexual forms of Plasmodium vivax and her rapid malaria antigen (QDx, Piramal Healthcare) test was positive for P. vivax. She was started on injection artesunate. Patient didn’t show significant improvement after 48 h of
Specificities and characteristics of beta 2 glycoprotein I-induced antiphospholipid antibodies. (1995)

Autoimmune antiphospholipid antibodies are associated with thrombosis, thrombocytopenia, and recurrent fetal death. These antibodies are thought to be directed against an epitope formed by phospholipids complexed with beta 2 glycoprotein I (beta 2GPI), a plasma protein with affinity for phospholipids. By immunizing mice and rabbits with heterologous beta 2GPI, we produced antibodies that bind strongly to acidic phospholipids in addition to binding to beta 2GPI. To evaluate the specificities of these antibodies, we passed the serum of a rabbit immunized with beta 2GPI through a cardiolipin (CL) affinity column and studied the bound and fall-through antibodies for binding to CL and beta 2GPI by ELISA. The results demonstrated the presence of two populations of antibodies, one with specificity for beta 2GPI alone without binding to phospholipids and the other with specificities for both CL and beta 2GPI. These dual-specificity antibodies are similar to the antiphospholipid antibodies present in autoimmune diseases because they bind to other acidic phospholipids in addition to CL and because their binding to phospholipids is enhanced by beta 2GPI and blocked by placental anticoagulant protein I (annexin V).
<i>Technical Note:</i> Improving Corrosion Resistance of Magnesium by Nonequilibrium Alloying with Yttrium (1993)

Significant improvements were achieved in the anodic polarization behavior of magnesium (Mg) by nonequilibrium alloying with 9 at% to 22 at% yttrium (Y). Alloys were fabricated using the nonequilibrium technique of magnetron cosputter deposition. Anodic potentiodynamic polarization experiments were conducted at various scan rates and pH values to assess the corrosion resistance of several MgY alloys. These alloys exhibited significantly enhanced corrosion behavior compared to pure Mg. Differences included higher breakdown potentials and lower passive current densities. X-ray diffraction of each alloy revealed the Y was retained in solid solution.
The Substituted‐Cysteine Accessibility Method (<scp>SCAM</scp>) to Elucidate Membrane Protein Structure (1999)

The substituted-cysteine accessibility method (SCAM) provides an approach to identifying the residues in the membrane-spanning segments that line a channel, transporter, or binding-site crevice. SCAM can also be used to determine differences in the structures of the membrane-spanning segments in different functional states of the proteins, to map electrostatic potential in the membrane-spanning domains, and to size a channel or binding-site crevice. The protocol in this unit describes the use of SCAM to map the binding-site crevice of a G-protein coupled receptor (GPCR) which binds ligand within the transmembrane portion of the receptor.
Calibration and use of plate meter regressions for pasture mass estimation in an Appalachian silvopasture (2011)

A plate meter for measuring pasture mass was calibrated at Agroforestry Research Site in Blacksburg, Virginia, USA, using six ungrazed plots of established tall fescue overseeded with orchardgrass. Each plot was interplanted with bare root honey locust and black walnut seedlings spaced along a gradient ranging from 1.8 to 11.0 m. Plate height (PH) of forage between trees was measured by placing a 46 mm × 46 mm × 5.6-mm-thick acrylic plastic plate meter on pasture canopy at six locations four times a season. PH was measured between ground and plate as it rested on pasture canopy. To calibrate the plate meter against a known dry matter yield, 50 × 50-cm clip plots followed each PH measurement. The resulting regression slope was 421 kg ha−1 cm−1, with an r 2 value of 0.86. Unique research investigating the response of forage mass to site elevation is presented using the developed equation. The field-calibrated regression slope of ruler height (RH) to PH was 1.71 cm cm−1, with an r 2 value of 0.87, showing good correlation between RH and PH. A comparable regional regression equation was found to adequately predict independent calibration clip plot data reported at this site. The results support the application of regression equations for estimating pasture mass in areas having similar climates and pasture composition.
Inhibition of clonal growth of <i>Giardia lamblia</i> and <i>Entamoeba histolytica</i> by metronidazole, quinacrine, and other antimicrobial agents (1981)

A convenient new method has facilitated precise determination of the susceptibility of the parasitic protozoa Giardia lamblia and Entamoeba histolytica to a number of antimicrobial agents. Inhibition of clonal growth in semisolid media was used to quantitate killing of parasites as a function of drug concentration and exposure time. The minimum lethal concentration of metronidazole for G. lamblia (2–4 mg/l) was similar to that determined by microscopic observation and subculture of organisms in liquid medium. Both parasites were killed rapidly by metronidazole: 50% in 5–7 h at 2 mg/l or in 1 h at 10 mg/l. L-Cysteine decreased the susceptibility of both parasites to metronidazole and exerted a lesser protective effect on Giard. lamblia with quinacrine, emetine, and chloramphenicol. When metronidazole and quinacrine were tested in combination, no strong synergistic or antagonistic interactions were observed. The susceptibilities of these unrelated intestinal pathogens to a variety of drugs were similar. However, Giard, lamblia was more sensitive to quinacrine and less sensitive to several inhibitors of protein synthesis.
Management Forecasts: What Do We Know? (1998)

Empirical research has addressed several issues related to management forecasts of earnings, including the motivations management may have to release forecasts voluntarily, bias in and accuracy of forecasts, and reactions to management forecasts. These issues are important to consider in order to interpret management forecasts properly. This article summarizes this body of research and concisely describes the findings. The discussion is intended to help analysts seeking to use the information in management forecasts in making their own assessments of a firm's future.
CAPA—An integrated computer-assisted personalized assignment system (1993)

A new integrated computer-assisted personalized assignment (CAPA) system that creates individual assignments for each student has been developed and found to be a powerful motivator. The CAPA system allows students to enter their answers to personalized assignments directly via networked terminals, gives immediate feedback and hints (allowing challenging questions), while providing the instructor with on-line performance information. The students are encouraged to study together which is known to be an effective learning strategy, but each must still obtain his/her own correct answers. Students are allowed to re-enter solutions to the problems before the due date without penalty, thus providing students with different skills levels the opportunity and incentive to understand the material without being judged during the learning process. The features and operation of the system are described, observations on its use in an introductory general physics class are reported, and some of the highly favorable student reactions are included.
A New Approach to the Problem of Carbon Monoxide Poisoning in Fuel Cells Operating at Low Temperatures (1988)

On resout le probleme de l'empoisonnement du catalyseur platine par la presence de CO a 100 ppm dans le gaz d'alimentation par l'injection d'O 2 a 4,5% dans le gaz d'alimentation constitue d'hydrogene
60‐Hz electric and magnetic fields generated by a distribution network (1987)

From a mobile unit, 60-Hz electric and magnetic fields generated by Hydro-Québec's distribution network were measured. Nine runs, representative of various human environments, were investigated. Typical values were 32 V/m and 0.16 microT. The electrical distribution networks investigated were major contributors to the electric and magnetic environments.
Secondary Chemoprevention of Barrett's Esophagus With Celecoxib: Results of a Randomized Trial (2007)

Administration of 200 mg of celecoxib twice daily for 48 weeks of treatment does not appear to prevent progression of Barrett's dysplasia to cancer.
Fiber type of optical coherence tomography with auto-focus design (2005)

Optical coherence tomography (OCT) is a novel technique for noninvasive imaging based on low coherence interferometer. In order to get image with high resolution, the highly precise scanning and sample stages are essential. In this study, we develop a new optical fiber type of OCT with a commercial auto-focus device to simultaneously measure refractive index and thickness of a single-layer for demonstration. In order to diminish the measurement error resulting from the slight vibration of the sample or sample stage, we design an auto-focus device into the new OCT system. As compared to the conventional one, the new OCT setup is simpler and processes the data speedily. It is found that the conventional OCT with an auto-focus device would be extremely difficult in controlling stages.
Amphiphilic Trithiols RC(CH<sub>2</sub>SH)<sub>3</sub> (2005)

We report on the synthesis of the amphiphilic molecules 1,1,1-tris(mercaptomethyl)undecane and 1,1,1-tris(mercaptomethyl)dec-9-ene starting from the corresponding tris(hydroxymethyl) compounds. In addition we describe the synthesis of an amphiphilic phosphite ligand possessing only one alkyl chain. These compounds are potential substrates for the monolayer protection of 2D surfaces and nanoparticles.
The Effects of Adopting and Using a Brand's Mobile Application on Customers’ Subsequent Purchase Behavior (2015)

Mobile applications (apps) have become an important platform for brands to interact with customers, but few studies have tested their effects on app adopters’ subsequent brand purchase behavior. This paper investigates whether adopters’ spending levels will change after they use a brand's app. Using a unique dataset from a coalition loyalty program with implementations of propensity score matching and difference-in-difference-in-difference methods, we compare the spending levels of app adopters with those of non-adopters. Specifically, we examine whether the use of the app's two main interactive features—information lookups and check-ins—influences adopters’ spending levels. We find that app adoption and continued use of the branded app increase future spending. Furthermore, customers who adopt both features show the highest increase. However, we also observe “the recency effect” – when customers discontinue using the app, their spending levels decrease. Our findings suggest that sticky apps which attract continuing uses can be a persuasive marketing tool because they provide portable, convenient, and interactive engagement opportunities, allowing customers to interact with the brand on a habitual basis. We recommend that firms should prioritize launching a mobile app to communicate with their customers, but they should also keep in mind that a poorly designed app, which customers abandon after only a few uses, may in fact hurt their brand experience and company revenues.
EVALUATION OF PRESERVATION CONDITIONS AND VARIOUS SOLUTIONS FOR SMALL BOWEL PRESERVATION (1994)

The aim of the study was to delineate the most optimal preservation conditions for small bowel grafts. Established preservation solutions such as EuroCollins, University of Wisconsin, histidine-tryptophane-ketoglutarate-Brettschneider, phosphate-buffered sucrose (PBS 140), and 3 new solutions--extracellular fluid (ECF), lactobionate fructose, and a modified lactobionate fructose solution--were compared with saline to determine the most optimal solution for the intestine. Recipient survival, standard histology, and glutaminase activity were used to assess the degree of injury encountered after 12 hr of preservation followed by transplantation. To evaluate the various preservation conditions, ECF was used at pH 6.8 (original ECF). Grafts were preserved most optimally when a vascular washout after the cold storage period was omitted and when topical rewarming of the graft with 37 degrees C saline before reperfusion was performed. Graft survival was not significantly different after preservation with any solution tested (50-83%). Highest graft survival (83%) was achieved with lactobionate fructose and PBS140. Histologic evaluation 20 min after reperfusion revealed minor differences between most groups; a slight advantage was observed for PBS140-preserved grafts. Mucosal glutaminase activity of PBS140-preserved grafts was significantly higher 20 min after reperfusion compared with any other solution evaluated, indicating a superior graft function. These data indicate that different preservation conditions have a great impact on postoperative graft survival and that PBS140 might be preferable to any of the other preservation solutions tested.
High-Frequency Soft-Switching DC-DC Converters for Voltage and Current DC Power Sources (2007)

The paper presents soft switching PWM DC-DC converters using power MOSFETs and IGBTs. The attention is focused mainly on the full-bridge converters suitable for high power applications. The properties of the PWM converters are described in comparison to other categories of soft switching converters. An overview of the switching techniques using in the DC-DC converters is included. Considerations are also given to the control methods. The principles of the switching and conduction losses reduction in the PWM converters are illustrated. Various types of snubber circuits are mentioned and their operation and limitations are discussed.