gebhart/patrepeval huggingface dataset:
Expression of interleukin-11 during the human menstrual cycle: coincidence with stromal cell decidualization and relationship to leukaemia inhibitory factor and prolactin (2000)

Interleukin-11 (IL-11) is crucial in the decidualization response of the uterine stroma to the implanting blastocyst in the mouse. This study examined the localization and expression of IL-11 in human endometrium throughout the menstrual cycle and of prolactin and leukaemia inhibitory factor (LIF) in secretory phase endometrium. The mRNA expression of IL-11 receptor alpha and the signalling component, gp130, in endometrial tissue were also determined. Immunoreactive IL-11 was highest in the secretory phase and present in decidualized stromal cells, glandular epithelial cells, endothelial and smooth muscle cells, and the mRNA expression was verified by in-situ hybridization. Decidual cells showed the most intense staining. IL-11 receptor alpha and gp130 mRNA were detected throughout the cycle with minimal variation. Expression of IL-11 mRNA and protein preceded that of prolactin. While immunoreactive prolactin was found in stromal, decidual and glandular epithelial cells, prolactin mRNA was confined to decidual cells. In contrast, endometrial LIF expression preceded IL-11 but was largely confined to the glandular epithelium. The sequence of appearance of LIF, IL-11 and prolactin suggests a synchronized role for each in the differentiation of the endometrium. The cyclical changes and cell type specific expression of IL-11 suggests a potential role in the decidualization of stromal cells.
ChemInform Abstract: Exploratory Studies of the Transition Metal Catalyzed Intramolecular Cyclization of Unsaturated α,α‐Dichloro Esters, Acids, and Nitriles. (1988)

Abstract Transition metal promoted intramolecular radical cyclizations of olefinic and acetylenic dichloro compounds such as (I), (V), (IX) or (XIII) (Kharasch‐type reactions) yield products such as (II), (VI), (X) or (XIV).
High mobility group box chromosomal protein 1 as a nuclear protein, cytokine, and potential therapeutic target in arthritis (2003)

High mobility group box chromosomal protein 1 (HMGB-1), a DNA binding protein, is an intracellular protein that facilitates DNA bending, stabilizes nucleosome formation, and modulates the interactions of regulatory molecules with their targets. Recent evidence has revealed that HMGB-1 is also a cytokine, because it 1) is released from activated monocyte/macrophages, 2) mediates delayed endotoxin lethality, 3) activates macrophages, 4) stimulates inflammation in vivo, and 5) is a therapeutic target in diverse animal models of inflammatory disease (1–4). Our review accompanies the report by Taniguchi and colleagues (5), in this issue of Arthritis & Rheumatism, of a new study of HMGB-1 in the pathogenesis of arthritis. We summarize here the history of research on HMGB-1 as an intracellular protein and discuss in more detail a rapidly growing body of evidence that implicates HMGB-1 as a cytokine that can mediate inflammation and arthritis. Some important new findings are highlighted, and a series of observations that warrant additional study are raised. The molecular basis of the cytokine activity of HMGB-1 and the biochemistry of this potentially important therapeutic target are discussed.
Induction of Urokinase-Type Plasminogen Activator Receptor by IL-1 β (1997)

Extensive tissue remodeling occurs in survivors of acute lung injury, leading to nearly normal histology and physiology in the majority of individuals, whereas others suffer significant impairment due to the development of pulmonary fibrosis. Alveolar epithelial cells play a central role in the repair process. They are strategically located to directly participate in the solubilization of intraalveolar fibrin deposits, and have the capacity to promote fibrinolysis. We have previously reported that interleukin-1 beta (IL-1 beta), an important inflammatory mediator in acute lung injury, upregulates urokinase-type plasminogen activator expression by human A549 cells (1). In this work, we show that IL-1 beta increases cell-surface plasmin generation, mediated in part by increased expression of urokinase receptor (u-PAR). Northern blot analyses demonstrated that IL-1 beta rapidly induces accumulation of u-PAR messenger RNA (mRNA) in a dose-dependent fashion, and that this effect is blocked by actinomycin. The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway. Okadaic acid, an inhibitor of serine/threonine phosphatases, markedly potentiates the effect of IL-1 beta on u-PAR mRNA levels. In contrast, dexamethasone, in concentrations as low as 10(-8) M, completely blocks the IL-1 beta-mediated increase in u-PAR mRNA. Half-life experiments show that dexamethasone has no effect on u-PAR mRNA stability. Aldosterone, at concentrations in which it binds primarily to the mineralocorticoid receptor, has no effect on u-PAR expression, suggesting that the glucocorticoid effect is due to a transrepressive mechanism. In summary, IL-1 beta increases cell-surface plasmin generation in A549 cells by coordinately upregulating urokinase and u-PAR expression. Transcriptional activation of the u-PAR gene involves PKC-dependent mechanisms, and glucocorticoid suppression is probably due to interactions between the glucocorticoid receptor and another transcriptional activating system such as activator protein-1 (AP-1) and/or nuclear factor-kB (NF-kB).
Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox (1996)

On neutrophil stimulation, the cytosolic components of NADPH oxidase, p67phox, p47phox, p40phox, as well as the Ras-related G-proteins Rac1 and Rac2, are translocated from the cytosol to cell membranes where they associate with a flavocytochrome b, forming a functional complex responsible for the production of oxygen radicals in phagocytes. In this paper we show that (a) in neutrophils from a patient with a form of chronic granulomatous disease (CGD) in which p67phox is absent, p47phox and Rac2, but not p40phox and Rac1 were translocated from the cytosol to the membrane on stimulation with formylmethionyl-leucylphenylalanine (fMLP) or phorbol 12-myristate 13-acetate (PMA); (b) in neutrophils from a patient with a form of CGD in which p47phox is absent, p67phox, p40phox and Rac1 failed to associate with the membrane on stimulation with fMLP or PMA, whereas Rac2 was translocated as in normal neutrophils. We also show that in neutrophils from a patient lacking p67phox, the amount of cytosolic p40phox was decreased by about 40%. These findings indicate that, on neutrophil stimulation, p67phox mediates the translocation of p40phox and Rac1 from the cytosol to cell membranes and that Rac2 associates with the membranes independently of p47phox and p67phox.
Privacy Infusion in Ubiquitous Computing (2007)

In recent years, ubiquitous computing applications span such areas as telemedicine, banking, and transportation that require user privacy protection. The realization of context-aware ubiquitous computing exasperates existing privacy concerns. Ubiquitous computing applications demand new privacy enhancing technologies for the information and communication environments where the users are equipped with flexible and portable applications to support the capture, communication, recall, organization and reuse of diverse information. In this paper, we develop a novel scheme for the infusion of privacy into context-aware ubiquitous computing. We present Precision, a system for privacy enhanced context-aware information fusion in ubiquitous computing environments. In our scheme, privacy is defined as a set of parameters encapsulated in composite data entities called privons, through which, we aim at infusing privacy into Precision. We evaluate our proposed scheme through real interactions in implementation of privons.
Fixed-bed catalytic process to produce synthetic lubricants from decene-1 (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFixed-bed catalytic process to produce synthetic lubricants from decene-1Ajay M. Madgavkar and Harold E. SwiftCite this: Ind. Eng. Chem. Prod. Res. Dev. 1983, 22, 4, 675–680Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/i300012a030https://doi.org/10.1021/i300012a030research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Optimal multi-content video decomposition for efficient video transmission over low-bandwidth networks (2003)

In this paper, an interactive framework for navigating video sequences over Internet protocol (IP)-based networks is presented using an optimal content-based video decomposition scheme. In particular, each video sequence is analyzed at different "content resolution levels", creating a hierarchy from the lowest (coarse) to the highest (fine) resolution. This content hierarchy is represented as a tree structure, each level of which corresponds to a particular content resolution, while the tree-nodes indicate the regions that the sequence content is partitioned at a given resolution. Optimal content-based video decomposition is performed by minimizing a cross correlation criterion so that the most representative shots from a video sequence or frames from a video shot are extracted. Experimental results on real-life video sequences show a sufficient representation of the visual content at each resolution level and a significant reduction of the transmission information, compared to the traditional sequential video scanning.
The synthesis and chemiluminescence of stable 1,2-dioxetane: An organic chemistry laboratory experiment (1982)

An expt. for the synthesis of adamantylideneadamantane-1,2-dioxetane illustrating the concepts of the singlet O reaction and chemiluminescence, is described. All intermediates and products can be identified by undergraduate students using routine spectroscopic anal. [on SciFinder (R)]
Minority-carrier characteristics of InGaAs metal-oxide-semiconductor structures using atomic-layer-deposited Al2O3 gate dielectric (2006)

Atomic layer deposition (ALD) provides a unique opportunity to integrate high-quality gate dielectrics on III-V compound semiconductors. ALD Al2O3 is a high-quality gate dielectric on III-V compound semiconductor with low interface trap density, low gate leakage, and high thermal stability. The authors study the minority-carrier response of Al2O3∕InGaAs metal-oxide-semiconductor (MOS) structures, which sheds light on the device physics for realizing high-performance inversion-type metal-oxide-semiconductor field-effect-transistor. The minority carriers in InGaAs do not respond to a small ac signal down to 100Hz at 300K, while they respond to up to 100kHz at 500K. Temperature dependent capacitance-voltage (C-V) measurement on the InGaAs MOS structure reveals the activation energy (Ea) of the minority-carrier recombination to be about 0.62eV.
Characterization of the proteases involved in the N‐terminal clipping of glucagon‐like‐peptide‐1‐antibody fusion proteins (2010)

In an attempt to develop high producing mammalian cell lines expressing glucagon-like-peptide-1-antibody fusion proteins (GLP-1), we have noted that the N-terminal GLP-1 portion of the fusion protein was susceptible to proteolytic degradation during cell culture, which resulted in an inactive product. The majority of the N-terminal clipped product appeared to be due to the removal of the entire biologically active peptide (30 amino acids) from the intact molecule. A number of parameters that influenced the degradative process were investigated. Additionally, protease inhibitors specific for each class of protease were tested. Results suggested that one or more serine-threonine class of protease(s) were involved in this process and inhibitors that are specific for this class of protease, including benzamidine hydrochloride could significantly inhibit the proteolytic degradation of the fusion proteins. Identification of the specific proteases involved in this process by shotgun proteomics methodology will pave the way for engineering the CHOK1SV cell line which will serve as a superior host for the production of future fusion protein products.
A Convenient Solid-Phase Synthesis of Coumarins by TMSOTf-Catalyzed Intramolecular Seleno-Arylation of Tethered Alkenes (2012)

TMSOTf-catalyzed intramolecular seleno-arylation of tethered alkenes was performed using polystyrene-supported succinimidyl selenide as the selenium source. This catalytic process provides an efficient method for the regioselective synthesis of dihydrocoumarins possessing a seleno functionality, followed by syn elimination of selenoxides to provide coumarins in good yields and purities. Suzuki cross-coupling reaction of the resin-bound bromodihydrocoumarin was also performed, and biphenyl coumarin was obtained by subsequent cleavage of selenium linker.
Communication- New Synthesis of 4-Hydroxycoumarins (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCommunication- New Synthesis of 4-HydroxycoumarinsV Shah, J Bose, and R ShahCite this: J. Org. Chem. 1960, 25, 4, 677–678Publication Date (Print):April 1, 1960Publication History Published online14 March 2003Published inissue 1 April 1960https://pubs.acs.org/doi/10.1021/jo01074a630https://doi.org/10.1021/jo01074a630research-articleACS PublicationsRequest reuse permissionsArticle Views1421Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lyme borreliosis–from tick bite to diagnosis and treatment (2017)

Lyme borreliosis is caused by certain genospecies of the Borrelia burgdorferi sensu lato complex, which are transmitted by hard ticks of the genus Ixodes. The most common clinical manifestation is erythema migrans, an expanding skin redness that usually develops at the site of a tick bite and eventually resolves even without antibiotic treatment. The infecting pathogens can spread to other tissues and organs, resulting in manifestations that can involve the nervous system, joints, heart and skin. Fatal outcome is extremely rare and is due to severe heart involvement; fetal involvement is not reliably ascertained. Laboratory support-mainly by serology-is essential for diagnosis, except in the case of typical erythema migrans. Treatment is usually with antibiotics for 2 to 4 weeks; most patients recover uneventfully. There is no convincing evidence for antibiotic treatment longer than 4 weeks and there is no reliable evidence for survival of borreliae in adequately treated patients. European Lyme borreliosis is a frequent disease with increasing incidence. However, numerous scientifically questionable ideas on its clinical presentation, diagnosis and treatment may confuse physicians and lay people. Since diagnosis of Lyme borreliosis should be based on appropriate clinical signs, solid knowledge of clinical manifestations is essential.
Interaction Between Finite Helical Axes and Facet Joint Forces Under Combined Loading (2008)

For clinical practice, patients immediately after the operation, or patients with facet joint arthritis should reduce or avoid axial rotation alone or in combination with other load applications, especially axial rotation plus lateral bending or flexion.
Postprandial metabolic events and fruit-derived phenolics: a review of the science (2010)

There is increasing evidence that the postprandial state is an important contributing factor to chronic disease. The role of fruit phenolic compounds to protect health and lower disease risk through their actions in mitigating fed-state metabolic and oxidative stressors is of interest and the topic of the present paper. Two main questions are posed: first, what is the role of plant foods, specifically fruits rich in complex and simple phenolic compounds in postprandial metabolic management; and second, does the evidence support consuming these fruits with meals as a practical strategy to preserve health and lower risk for disease? This review provides an overview of the postprandial literature, specifically on the effect of fruits and their inherent phenolic compounds in human subjects on postprandial lipaemia, glycaemia/insulinaemia and associated events, such as oxidative stress and inflammation. Among the identified well-controlled human trials using a postprandial paradigm, >50 % of the trials used wine or wine components and the remaining used various berries. Notwithstanding the need for more research, the collected data suggest that consuming phenolic-rich fruits increases the antioxidant capacity of the blood, and when they are consumed with high fat and carbohydrate 'pro-oxidant and pro-inflammatory' meals, they may counterbalance their negative effects. Given the content and availability of fat and carbohydrate in the Western diet, regular consumption of phenolic-rich foods, particularly in conjunction with meals, appears to be a prudent strategy to maintain oxidative balance and health.
Using Chatbots for Network Management Training through Problem-based Oriented Education (2007)

This work presents an investigation of the use of ChatBots as a tool for network management training, through the use of the problem-based oriented (PBO) approach. Network management can be defined as the act of initializing, monitoring and modifying the operation of the functions that directly support the user requirements. Managing the current heterogeneous networks requires the collection of large quantities of data from the network; data that must then be analyzed before a management activity is initiated. Due to this fact, this domain represents an opportunity for using the PBO approach in education. In our approach, we have created Dorothy, a network management-aware ChatBot that is able to interact not only with the user, but also with the managed network via management protocols.
Randomised trial of cranberry-lingonberry juice and <i>Lactobacillus</i> GG drink for the prevention of urinary tract infections in women (2001)

Abstract Objective: To determine whether recurrences of urinary tract infection can be prevented with cranberry-lingonberry juice or with Lactobacillus GG drink. Design: Open, randomised controlled 12 month follow up trial. Setting: Health centres for university students and staff of university hospital. Participants: 150 women with urinary tract infection caused by Escherichia coli randomly allocated into three groups. Interventions: 50 ml of cranberry-lingonberry juice concentrate daily for six months or 100 ml of lactobacillus drink five days a week for one year, or no intervention. Main outcome measure: First recurrence of symptomatic urinary tract infection, defined as bacterial growth ≥10 5 colony forming units/ml in a clean voided midstream urine specimen. Results: The cumulative rate of first recurrence of urinary tract infection during the 12 month follow up differed significantly between the groups (P=0.048). At six months, eight (16%) women in the cranberry group, 19 (39%) in the lactobacillus group, and 18 (36%) in the control group had had at least one recurrence. This is a 20% reduction in absolute risk in the cranberry group compared with the control group (95% confidence interval 3% to 36%, P=0.023, number needed to treat=5, 95% confidence interval 3 to 34). Conclusion: Regular drinking of cranberry juice but not lactobacillus seems to reduce the recurrence of urinary tract infection. What is already known on this topic Up to 60% of women will have a urinary tract infection and a third of them will have several recurrences Vaccinium berries and products containing lactobacilli may affect the coliform bacteria that cause urinary tract infection What this study adds 50 ml of cranberry-lingonberry juice concentrate daily reduced recurrences of symptomatic urinary tract infection by about half compared with the control group Lactobacillus GG drink had no effect on recurrence Self treatment with cranberry juice may reduce the need for antimicrobials for recurrent urinary tract infection
TorsinA immunoreactivity in brains of patients with <i>DYT1</i> and non- <i>DYT1</i> dystonia (2002)

A mutation of the DYT1 gene, which codes for torsinA, has been identified as the cause of one form of autosomal dominantly inherited dystonia. TorsinA immunohistochemistry was used to examine a case of DYT1, and several cases of non-DYT1, dystonia. No evidence was found for alterations of immunoreactivity at the light microscopic level, specifically neither cytoplasmic aggregations nor colocalization of torsinA immunoreactivity with a marker for endoplasmic reticulum. These findings contrast with results of recent cell culture studies of torsinA.