gebhart/patrepeval huggingface dataset:
Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines (2016)

Lactic acid bacteria (LAB) can produce a huge amount of bioactive compounds. Since their elective habitat is food, especially dairy but also vegetal food, it is frequent to find bioactive molecules in fermented products. Sometimes these compounds can have adverse effects on human health such as biogenic amines (tyramine and histamine), causing allergies, hypertensive crises, and headache. However, some LAB products also display benefits for the consumers. In the present review article, the main nitrogen compounds produced by LAB are considered. Besides biogenic amines derived from the amino acids tyrosine, histidine, phenylalanine, lysine, ornithine, and glutamate by decarboxylation, interesting peptides can be decrypted by the proteolytic activity of LAB. LAB proteolytic system is very efficient in releasing encrypted molecules from several proteins present in different food matrices. Alpha and beta-caseins, albumin and globulin from milk and dairy products, rubisco from spinach, beta-conglycinin from soy and gluten from cereals constitute a good source of important bioactive compounds. These encrypted peptides are able to control nutrition (mineral absorption and oxidative stress protection), metabolism (blood glucose and cholesterol lowering) cardiovascular function (antithrombotic and hypotensive action), infection (microbial inhibition and immunomodulation) and gut-brain axis (opioids and anti-opioids controlling mood and food intake). Very recent results underline the role of food-encrypted peptides in protein folding (chaperone-like molecules) as well as in cell cycle and apoptosis control, suggesting new and positive aspects of fermented food, still unexplored. In this context, the detailed (transcriptomic, proteomic, and metabolomic) characterization of LAB of food interest (as starters, biocontrol agents, nutraceuticals, and probiotics) can supply a solid evidence-based science to support beneficial effects and it is a promising approach as well to obtain functional food. The detailed knowledge of the modulation of human physiology, exploiting the health-promoting properties of fermented food, is an open field of investigation that will constitute the next challenge.
Morpholine Condensations (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMorpholine CondensationsChester B. Kremer, M. Meltsner, and L. GreensteinCite this: J. Am. Chem. Soc. 1939, 61, 9, 2552Publication Date (Print):September 1, 1939Publication History Published online1 May 2002Published inissue 1 September 1939https://pubs.acs.org/doi/10.1021/ja01878a503https://doi.org/10.1021/ja01878a503research-articleACS PublicationsRequest reuse permissionsArticle Views120Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The evidence for antidepressant use in bipolar depression. (2006)

Mood elevation, which includes mania, hypomania, and mixed states, was previously considered the defining symptom of bipolar disorder, but bipolar depression by comparison is actually a much more substantial challenge to diagnose and treat. Recent studies, including research by the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), found that patients with bipolar disorder spend longer periods of time in depressive episodes and are more likely to relapse to depression compared with mania or hypomania. However, the treatment of bipolar depression is hampered by the limited number and varying quality of available studies of pharmacologic treatments to guide clinical decision making. Clinicians should rely on studies with the highest level of evidence (category A) when prescribing appropriate antidepressant treatments. The standard care pathways outlined by STEP-BD to aid clinicians in treating varying phases of bipolar disorder provide data on the use of various treatments for bipolar depression and their outcomes. While some treatments have the potential to induce mania, others appear to have some efficacy without inducing mania.
Efficacy of ticarcillin-clavulanic acid for treatment of experimental Staphylococcus aureus endocarditis in rats (1992)

The efficacy of ticarcillin-clavulanic acid was compared with the efficacies of standard antistaphylococcal agents (flucloxacillin, oxacillin, nafcillin, and vancomycin) and ticarcillin in an experimental model of Staphylococcus aureus endocarditis. Therapy was either initiated soon (8 h) after infection, when numbers of bacteria in aortic valve vegetations were relatively low (approximately 6 to 8 log10 CFU/g), or delayed until 24 h after infection, when the vegetations usually contained greater than 9 log10 CFU/g. Doses of the antibiotic were selected to produce peak concentrations in rat serum similar to those achievable in humans after administration of parenteral therapeutic doses. Ticarcillin-clavulanic acid was more effective overall than ticarcillin alone against endocarditis caused by beta-lactamase-producing strains of S. aureus, illustrating the beta-lactamase-inhibitory activity of clavulanic acid in vivo. Ticarcillin-clavulanic acid was as effective as the standard antistaphylococcal beta-lactam agents flucloxacillin, oxacillin, and nafcillin in these infections, whereas vancomycin was generally less active. These results illustrate the clinical potential of ticarcillin-clavulanic acid in the prophylaxis or therapy of severe staphylococcal infections.
Erythema multiforme bullosum associated with Trichomonas infection (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Vegetable Cultivar Descriptions for North America List 27 2013 (2013)

This list of the North American vegetable cultivars was developed using the database of cultivars registered with the American Seed Trade Association, as well as published descriptions from scientific journals, seed catalogs, and websites of seed companies. Assistant editors responsible for each crop were instructed to obtain as much information as possible about the cultivars available to North American growers. The crop species are listed alphabetically, with cultivars listed alphabetically within each of those.
Billion-Fold Increase in Tip-Enhanced Raman Signal (2014)

A billion-fold increase in the Raman signal over conventional tip-enhanced Raman spectroscopy/microscopy (TERS) is reported. It is achieved by introducing a stimulating beam confocal with the pump beam into a conventional TERS setup. A stimulated TERS spectrum, closely corresponding to its spontaneous TERS counterpart, is obtained by plotting the signal intensity of the strongest Raman peak of an azobenzene thiol self-assembled monolayer versus the stimulating laser frequency. The stimulated TERS image of azobenzene thiol molecules grafted onto Au ⟨111⟩ clearly shows the surface distribution of the molecules, whereas, when compared to the simultaneously recorded surface topography, it presents an image contrast of different nature. The experimentally obtained stimulated gain is estimated at 1.0 × 10(9), which is in reasonable agreement with the theoretically predicted value. In addition to the signal increase, the signal-to-noise ratio was 3 orders of magnitude higher than in conventional spontaneous TERS. The proposed stimulated TERS technique offers the possibility for a substantially faster imaging of the surface with respect to normal TERS.
Dehydrogenation and coupling reactions in the presence of iodine and molten salt hydrogen iodide acceptors (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDehydrogenation and coupling reactions in the presence of iodine and molten salt hydrogen iodide acceptorsCharles T. Adams, Stanley G. Brandenberger, J. B. DuBois, George S. Mill, M. Nager, and Davis B. RichardsonCite this: J. Org. Chem. 1977, 42, 1, 1–6Publication Date (Print):January 1, 1977Publication History Published online1 May 2002Published inissue 1 January 1977https://pubs.acs.org/doi/10.1021/jo00421a001https://doi.org/10.1021/jo00421a001research-articleACS PublicationsRequest reuse permissionsArticle Views407Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Unveiling the mechanisms of dressed-photon–phonon etching based on hierarchical surface roughness measure (2013)

Dressed-photon–phonon (DPP) etching is a disruptive technology in planarizing material surfaces because it completely eliminates mechanical contact processes. However, adequate metrics for evaluating the surface roughness and the underlying physical mechanisms are still not well understood. Here, we propose a two-dimensional hierarchical surface roughness measure, inspired by the Allan variance, that represents the effectiveness of DPP etching while conserving the original two-dimensional surface topology. Also, we build a simple physical model of DPP etching that agrees well with the experimental observations, which clearly shows the involvement of the intrinsic hierarchical properties of dressed photons, or optical near-fields, in the surface processing.
Antioxidant strategies for neurodegenerative diseases (2001)

A very large body of evidence supports the involvement of oxidative stress in neurodegenerative pathologies. Therefore, therapies based on administration of antioxidant and reactive oxygen species (ROS) scavenging substances have been widely proposed for treatment of both acute and chronic neuropathological diseases. In the present review, several recent patents (mostly from 1998 - 2000) based on the proposed use of antioxidant strategies to treat neurodegenerative diseases are considered. In particular, the following classes of patents are examined: patents for novel antioxidant and ROS scavengers, pharmaceutical compositions in which antioxidant and ROS scavengers are claimed together with other pharmacological tools, patents based on new biotechnological and gene therapy approaches, and patents based on enzymatic manipulation of ROS production and elimination. In the comment, the most promising perspectives stemming from these patents are discussed; in particular: (i.) the usefulness of pharmaceutical compositions able to counteract the deleterious effects of excessive amounts of free radicals originating from different cellular process, without blocking the physiological beneficial action of their controlled production; (ii.) the potential beneficial effects of combining antioxidant treatments with modulation of the activity of receptors for excitatory amino acid and modulation of calcium levels; (iii.) the tremendous future impact of biotechnological and gene therapy techniques.
Fully-automatic Translation of Open Workflow Net Models into Simple Abstract BPEL Processes (2008)

Abstract: On the one hand, Petri net models have a successful history in the modeling, simulation, and verification of workflows and business processes. On the other hand, BPEL is the de facto standard for describing and implementing Web service-based business processes. With abstract BPEL processes, BPEL can also be used as modeling language. However, being a complicated language with many syntactic constraints, abstract BPEL processes impede a straightforward modeling. BPEL processes which can be easily refined to executable BPEL processes. This approach combines strengths of Petri nets in modeling and verification with the ability to execute and port BPEL processes. Furthermore, it completes the Tools4BPEL framework to synthesize BPEL processes which are correct by design. 1
Modular Multilayer Perceptron for WLAN Based Localization (2006)

Location Awareness is key capability of Context-Aware Ubiquitous environments. Received Signal Strength (RSS) based localization is increasingly popular choice especially for in-building scenarios after pervasive adoption of IEEE 802.11 Wireless LAN. Fundamental requirement of such localization systems is to estimate location from RSS at a particular location. Multipath propagation effects make RSS to fluctuate in unpredictable manner, introducing uncertainty in location estimation. Moreover, in real life situations RSS values are not available at some locations all the time making the problem more difficult. We employ Modular Multi Layer Perceptron (MMLP) approach to effectively reduce the uncertainty in location estimation system. It provides better location estimation results than other approaches and systematically caters for unavailable signals at estimation time.
The Anomalous Behavior of m-Trifluoromethylnitrosobenzene Dimer<sup>1</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Anomalous Behavior of m-Trifluoromethylnitrosobenzene Dimer1L. A. Errede and H. R. DavisCite this: J. Org. Chem. 1963, 28, 5, 1430–1431Publication Date (Print):May 1, 1963Publication History Published online1 May 2002Published inissue 1 May 1963https://doi.org/10.1021/jo01040a534RIGHTS & PERMISSIONSArticle Views50Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (295 KB) Get e-Alerts Get e-Alerts
Hydrophobic Shell Loading of Biopolyelectrolyte Capsules (2011)

A versatile method to selectively encapsulate water-insoluble molecules in the nanoshell of layer-by-layer capsules made exclusively of polysaccharides is described. This relies on the very high affinity of hydrophobic molecules for an alkylated hyaluronic acid used as a polyanionic partner of a chitosan derivative for the capsule synthesis. The hydrophobic molecules entrapped in the nanoshell can be delivered intracellularly in dendritic cells. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Realtime Structured Light Vision with the Principle of Unique Color Codes (2007)

To date, several successful structured light vision systems for accurate 3D measurement in machine vision have been set up. However, these are usually limited to scanning stationary objects or static environments since tens of images have to be captured for recovering one 3D scene, which results in the industry largely avoiding this technology. This paper presents a method of grid-pattern design based on the principles of uniquely color-encoded structured light, to improve the reconstruction efficiency for real-time processing. For a live scene, the 3D measurement is desired to only capture a single image. To realize this, an important problem for the color-encoded projection is the unique indexing of the color codes in the image. It is essential that each light grid be uniquely identified by incorporating the local neighborhoods in the pattern so that 3D reconstruction can be performed with only local analysis of a single image. This paper describes such a method in the design of the special grid patterns and its corresponding 3D reconstruction method for fast vision perception.
An Advanced-Architectur CMOS/SOS Microprocessor (1982)

A language-directed stack architecture, implemented in two-micrometer CMOS/SOS, yields a 16-bit microprocessor having high throughput and high compiled code density.
Fault detection and management system for fault-tolerant switched reluctance motor drives (1991)

The superior fault tolerance characteristics of the switched reluctance motor (SRM) have been proved in a working laboratory drive system. The program started by defining the performance effects of various types of motor winding faults. Motor winding fault detection devices were developed, along with control circuitry, to isolate a faulted winding by blocking the gating signals to the semiconductor power switches of the affected phase. The developments were implemented on a laboratory demonstration drive to determine the efficacy of the various fault detectors. The laboratory drive demonstrates that winding faults can be applied to the running drive and can be immediately detected and isolated without causing damage to the inverter circuitry and without causing drive misoperation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A High-Field / High-Frequency Electron Paramagnetic Resonance Spectrometer (360 GHz / 14 T) (2000)

# Abstract Electron paramagnetic resonance (EPR) has traditionally been carried out at microwave frequencies between 9 and 10 GHz (X-band) and magnetic fields around 0.3 T. In the last twenty years, however, a strong trend has evolved to expand the range of microwave frequency and magnetic field to higher values. The origin of this development lies in the fact that high field / high frequency EPR offers several great advantages when compared to conventional X-band EPR. The most important of these advantages are the increased spectral resolution, a gain in sensitivity for samples of limited size or quantity, the accessibility of zero-field fine structure transitions that are ´EPR-silent´ at lower frequencies and the sensitivity to different motional frequency regimes. In the course of the work presented here, a spectrometer operating at a frequency of 360 GHz and at magnetic fields up to 14 T was built up. In conjunction with the existing X-band (9.5 GHz) and W-band (95 GHz) spectrometers this considerably expands the scope of measurement frequencies accessible in our workgroup. As has become obvious already from the experiences gained from the extension to W-band spectroscopy, performing EPR experiments at multiple frequencies provides a better insight into physical and chemical processes than can be achieved by observations at a single frequency only. Considering the limited number of working spectrometers, it is easily understandable that so far no single best way of dealing with the technical problems encountered when working with frequencies above 200 GHz has evolved. With the strong focus of our workgroup on the elucidation of the structure and functioning principles of bioorganic systems it was of particular interest to see whether the chosen spectrometer configuration would provide a sufficiently high sensitivity and resolution to observe well resolved spectra of paramagnetic biomolecules. One of the goals of this work therefore was to characterize the performance of the spectrometer and to get a better idea about which parts should be optimized. This thesis is structured as follows: Chapter 3 will give a motivation for the extension of EPR to higher microwave frequencies and magnetic fields. In chapter 4, an overview of the theory of Gaussian optics will be given to the extent needed to describe the resonator and transmission line of the spectrometer. The experimental setup of the spectrometer will then be described, followed by the description of the numerical simulation routines developed for the interpretation of the observed spectra. Subsequently, the first experimental results obtained with the spectrometer will be presented. In a final discussion, the main results will be summed up and the most imminent future projects will be plotted out.
A Bayesian Nonparametric Approach to Modeling Mobility Patterns (2010)

Constructing models of mobile agents can be difficult without domain-specific knowledge. Parametric models flexible enough to capture all mobility patterns that an expert believes are possible are often large, requiring a great deal of training data. In contrast, nonparametric models are extremely flexible and can generalize well with relatively little training data. We propose modeling the mobility patterns of moving agents as a mixture of Gaussian processes (GP) with a Dirichlet process (DP) prior over mixture weights. The GP provides a flexible representation for each individual mobility pattern, while the DP assigns observed trajectories to particular mobility patterns. Both the GPs and the DP adjust the model's complexity based on available data, implicitly avoiding issues of over-fitting or under-fitting. We apply our model to a helicopter-based tracking task, where the mobility patterns of the tracked agents — cars — are learned from real data collected from taxis in the greater Boston area.