gebhart/patrepeval huggingface dataset:
Gene therapy in transplantation. (2001)

In transplantation, gene therapy strategies to prolong graft survival involve gene transfer and expression of immunomodulatory or graft-protecting molecules. The local production of immunosuppressive molecules has the potential to reduce their systemic side effects, and to increase their bioavailability and hence their therapeutic efficiency. Ex vivo gene transfer enables manipulation prior to engraftment. Vectors have now been developed that can optimally transfer the relevant genes to various cells, tissues and organs. The elimination of genetically modified cells can even be time-controlled by prodrug administration in suicide gene therapy systems. Gene transfer to stem cells may eventually lead to accelerated tissue repair and regeneration. In addition, xenotransplantation and organ cloning techniques have the potential to resolve the current shortage of donor organs.
Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells (2015)

Accumulating epidemiologic evidence has revealed that metabolic syndrome is an independent risk factor for psoriasis development and is associated with more severe psoriasis. Adiponectin, primarily recognized as a metabolic mediator of insulin sensitivity, has been newly drawing attention as a mediator of immune responses. Here we demonstrate that adiponectin regulates skin inflammation, especially IL-17-related psoriasiform dermatitis. Mice with adiponectin deficiency show severe psoriasiform skin inflammation with enhanced infiltration of IL-17-producing dermal Vγ4+γδ-T cells. Adiponectin directly acts on murine dermal γδ-T cells to suppress IL-17 synthesis via AdipoR1. We furthermore demonstrate here that the adiponectin level of skin tissue as well as subcutaneous fat is decreased in psoriasis patients. IL-17 production from human CD4- or CD8-positive T cells is also suppressed by adiponectin. Our data provide a regulatory role of adiponectin in skin inflammation, which would imply a mechanism underlying the relationship between psoriasis and metabolic disorders.
LETTERS TO THE EDITOR (1950)

LETTERS TO THE EDITOR Get access H. FAIRFIELD SMITH H. FAIRFIELD SMITH The Rubber Institute of MalayaP.O. Box 150, Kuala Lumpur, Malaya Search for other works by this author on: Oxford Academic Google Scholar Forestry: An International Journal of Forest Research, Volume 23, Issue 1, 1950, Pages 56–58, https://doi.org/10.1093/oxfordjournals.forestry.a062974 Published: 01 April 1950
Multiplier-free decimator algorithms for superresolution oversampled converters (2002)

A class of efficient linear-phase finite impulse response (FIR) decimators for attenuating the out-of-band noise generated by a high-order sigma-delta analog-to-digital modular is introduced. The stopband attenuation of these decimators is more than 120 dB. The decimators contain no general multipliers and a few data memory locations, thereby making them easily VLSI-realizable. This is achieved by using several decimation stages, with each stage containing a small number of delays and arithmetic operations. Some of the stages are constructed using low-order building blocks which are combined to give a selective filter using a few additional tap coefficients and adders. The output sampling rate of these decimators is the minimum possible one, and the proposed decimators can be used, with very slight changes, for many oversampling ratios. These decimators highly attenuate the undesired out-of-band signal components of the input signal, thus significantly relaxing the antialiasing prefilter requirements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Characterization of grafting in the emulsion polymerization of vinyl acetate using poly(vinyl alcohol) as stabilizer (2001)

Emulsion polymerizations of vinyl acetate (VAc) with polyvinyl alcohol (PVA) as emulsifier were carried out by both batch and semicontinuous processes. The extent of grafting of vinyl acetate onto the PVA chains was investigated by a new method for separating the various polymer fractions in high solids content latexes. The quantification was carried out by a three-step separation and selective solubilization of the PVAc latexes. After the separation, the water-soluble PVA and the solvent-soluble PVAc components were characterized by gel permeation chromatography and 13C–NMR, from which the accuracy of this method was verified. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 82: 1739–1747, 2001
A randomized, double-blind, placebo-controlled study of the efficacy and safety of MNK-795, a dual-layer, biphasic, immediate-release and extended-release combination analgesic for acute pain (2013)

OC/APAP ER was efficacious and generally well tolerated in an established model of moderate to severe acute pain, providing an onset of analgesia in approximately 30 minutes and sustained pain relief over the 12 hour dosing period.
Stiffness-distortion sarcomere model for muscle simulation (1999)

A relatively simple method is presented for incorporating cross-bridge mechanisms into a muscle model. The method is based on representing force in a half sarcomere as the product of the stiffness of all parallel cross bridges and their average distortion. Differential equations for sarcomeric stiffness are derived from a three-state kinetic scheme for the cross-bridge cycle. Differential equations for average distortion are derived from a distortional balance that accounts for distortion entering and leaving due to cross-bridge cycling and for distortion imposed by shearing motion between thick and thin filaments. The distortion equations are unique and enable sarcomere mechanodynamics to be described by only a few ordinary differential equations. Model predictions of small-amplitude step and sinusoidal responses agreed well with previously described experimental results and allowed unique interpretations to be made of various response components. Similarly good results were obtained for model reproductions of force-velocity and large-amplitude step and ramp responses. The model allowed reasonable predictions of contractile behavior by taking into account what is understood to be basic muscle contractile mechanisms.
Neuroendocrine changes in heart failure and their clinical relevance (1995)

The pathophysiology of heart failure is closely associated with neuroendocrine changes. Activation of these humoral systems apparently serves as a compensatory mechanism for the failing circulation. However, overshoot of such mechanisms may further depress cardiac function by increasing afterload, resulting in a vicious cycle of reflex neuroendocrine activation. Corollary decreases in renal function activate the renin-angiotensin-aldosterone system as well, which further contributes to the cycle of downward-spiralling cardiac function. Many hormonal factors are increased in congestive heart failure. While some influences are vasodilatory, the net effect is marked vasoconstriction. The level of activation of these systems apparently corresponds to the severity of heart failure. Furthermore, elevated levels of these hormones, including norepinephrine, atrial natriuretic factor, plasma renin, and plasma arginine vasopressin, may play a more direct role in worsening heart failure. In fact, elevated catecholamine levels are directly related to prognosis. Catecholamines increase myocardial oxygen demand and are also arrhythmogenic. Oral catecholamines and phosphodiesterase inhibitors, which work by similar mechanisms, have yielded increased mortality rates in heart failure trials. In contrast, mortality rates are reduced in patients treated with angiotensin-converting enzyme inhibitors. Thus, it is clear that neuroendocrine changes are not only a marker of the severity of heart failure, but also directly worsen it. Interventions that antagonize or diminish these neuroendocrine changes apparently benefit patients with heart failure.
Derivation and Characterization of Hematopoietic Cells From Human Embryonic Stem Cells (2006)

In vitro, the aggregation of pluripotent human embryonic stem cells (hESC) into cell clusters termed embryoid bodies (EB) allows for the spontaneous differentiation of hESC into progeny representing endoderm, mesoderm, and ectoderm lineages. During human EB (hEB) differentiation, stochastic emergence of hematopoietic cells can be enhanced by a combination of hematopoietic cytokines and the ventral mesoderm inducer bone morphogenetic protein (BMP)-4. Dependent on the presence of hematopoietic cytokines and BMP-4, vascular endothelial growth factor (VEGF-A165) selectively promotes erythropoietic development toward the primitive lineage. The effects of VEGF-A165 can be augmented by erythropoietin (EPO). Hematopoietic cells are derived from a rare subpopulation of hemogenic precursors during hEB development. These hemogenic precursors lack CD45, but express PECAM-1, Flk-1, and VE-cadherin (hereinafter CD45(neg)PFV) and are solely responsible for hematopoietic cell fate. Human ESC-derived hematopoietic cells have similar colony and cellular morphologies to those derived from committed adult hematopoietic tissues, and also show repopulating capacity in immune deficient mice after intrabone marrow transplantation. In this chapter, we describe methods that have been successfully applied in our laboratory, including (1) generation of hematopoietic cells by EB formation; (2) augmentation of hematopoiesis by use of hematopoietic cytokines and BMP-4; (3) promotion of erythropoietic development by addition of VEGF-A165 and EPO; (4) isolation of CD45(neg)PFV hemogenic precursors and generation of hematopoietic cells from these precursors; and (5) characterization of hESC-derived hematopoietic cells in vitro and in vivo.
Organic molecules as mediators and catalysts for photocatalytic and electrocatalytic CO<sub>2</sub>reduction (2012)

Reduction of CO(2) by electrochemical and photoelectrochemical methods to produce carbon-rich fuels is a heavily pursued research theme. Most of the current efforts are focused on the development of transition-metal-based catalysts. In this tutorial review, we present an overview of the development of organic molecules as mediators and catalysts for CO(2) reduction. Four classes of organic molecules are discussed: tetraalkylammonium salts, aromatic esters and nitriles, ionic liquids, and pyridinium derivatives. It is shown that reactions mediated or catalyzed by these organic molecules can be competitive compared to their metal-catalyzed counterparts, both in terms of product selectivity and energy efficiency.
Abnormal Serotonergic Stimulation of Cortisol Production in Obstructive Sleep Apnea (1995)

Because serotonin (5-HT) precursor or reuptake inhibitors improve obstructive sleep apnea (OSA), we hypothesized that brain serotonergic activity may be decreased in OSA. To test this hypothesis, we measured the cortisol response to the ingestion of L-5-hydroxytryptophan (L-5-HTP), a 5-HT precursor that is decarboxylated to 5-HT in the brain. Either L-5-HTP or an identical-looking placebo was administered at 0800, and blood was obtained over the following 4 h for serum cortisol determination. A placebo-controlled ACTH stimulation test was performed to evaluate adrenal function. We found that a group of 11 OSA patients had significantly higher cortisol production after L-5-HTP administration compared with a group of 11 control nonapneic subjects. The pretest cortisol levels and ACTH stimulation test results were not different between the two groups. We conclude that the cortisol response to L-5-HTP was elevated in the OSA patients studied, most likely as a result of increased hypophyseal 5-HT activity. We speculate that the 5-HT postsynaptic receptors that induce corticotropin releasing factor production and release are upregulated, or supersensitized, as a result of a brain 5-HT-deficient state that exists during sleep in OSA. We anticipate that medullary serotonergic neurons that affect ventilation would be altered similarly.
Advanced channel coding techniques using bit-level soft information (2007)

In this dissertation, advanced channel decoding techniques based on bit-level soft information are studied. Two main approaches are proposed: bit-level probabilistic iterative decoding and bit-level algebraic soft-decision (list) decoding (ASD). \nIn the ﬁrst part of the dissertation, we ﬁrst study iterative decoding for high density parity check (HDPC) codes. An iterative decoding algorithm, which uses the sum product algorithm (SPA) in conjunction with a binary parity check matrix adapted in each decoding iteration according to the bit-level reliabilities is proposed. In contrast to the common belief that iterative decoding is not suitable for HDPC codes, this bit-level reliability based adaptation procedure is critical to the conver-gence behavior of iterative decoding for HDPC codes and it signiﬁcantly improves the iterative decoding performance of Reed-Solomon (RS) codes, whose parity check matrices are in general not sparse. We also present another iterative decoding scheme for cyclic codes by randomly shifting the bit-level reliability values in each iteration. The random shift based adaptation can also prevent iterative decoding from getting stuck with a significant complexity reduction compared with the reliability based parity check matrix adaptation and still provides reasonable good performance for short-length cyclic codes. \nIn the second part of the dissertation, we investigate ASD for RS codes using bit-level soft information. In particular, we show that by carefully incorporating bit¬level soft information in the multiplicity assignment and the interpolation step, ASD can significantly outperform conventional hard decision decoding (HDD) for RS codes with a very small amount of complexity, even though the kernel of ASD is operating at the symbol-level. More importantly, the performance of the proposed bit-level ASD can be tightly upper bounded for practical high rate RS codes, which is in general not possible for other popular ASD schemes. \nBit-level soft-decision decoding (SDD) serves as an eﬃcient way to exploit the potential gain of many classical codes, and also facilitates the corresponding per-formance analysis. The proposed bit-level SDD schemes are potential and feasible alternatives to conventional symbol-level HDD schemes in many communication sys-tems.
Conclusion The Meanings of ‘Enter’ and ‘Exit’/‘Exeunt’ (2002)

I began this book by questioning the Elizabethan theatrical meanings of 'enter' and 'exit'/'exeunt'. The entries in Alan C. Dessen and Leslie Thomson's Dictionary of Stage Directions, of course, include these most frequently used stage directions, and the explanations of their usages are enlightening, illustrating several types of common locutions attached to 'enter' or 'exit'/'exeunt'. 1 But, regrettably, the Dictionary does not define the meanings of these terms themselves. I should like to close this book by giving a brief summary of what we have found about the basic meanings and matters of 'enter' and 'exit'/'exeunt'. KeywordsPlaying SpaceEntry DirectionBasic MeaningStage PostOrdinary MannerThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
The Surface Tension of Crude Oils. (1925)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Surface Tension of Crude Oils.Ellery H. HarveyCite this: Ind. Eng. Chem. 1925, 17, 1, 85Publication Date (Print):January 1, 1925Publication History Published online1 May 2002Published inissue 1 January 1925https://doi.org/10.1021/ie50181a042RIGHTS & PERMISSIONSArticle Views928Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (157 KB) Get e-Alerts
Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride. (1990)

Andrographolide, a diterpenoid lactone, was isolated (yield 0.78% w/w) from A. paniculata (whole plant). Its LD50 in male mice was 11.46 g/kg, ip. Antihepatotoxic activity of andrographolide (100 mg/kg, ip) was compared with 861.33 mg/kg, ip, of the methanolic extract (equivalent to 100 mg/kg of andrographolide) and 761.33 mg/kg ip, of the andrographolide-free methanolic extract (equivalent to 861.33 mg/kg of the methanolic extract) of the plant, using CCl4-intoxicated rats. Biochemical parameters like serum transaminases--GOT and GPT, serum alkaline phosphatase, serum bilirubin and hepatic triglycerides were estimated to assess the liver function. Overall inhibition of CCl4-induced increase in the five biochemical parameters was found to be 48.6 per cent (andrographolide), 32.0 per cent (methanolic extract) and 15.0 per cent (andrographolide-free methanolic extract). These biochemical observations were supplemented by histopathological examination of the liver slices. Further, andrographolide (100 mg/kg, ip) was found to normalize completely the CCl4-induced increase in the pentobarbitone induced sleep time of mice. The results suggest that andrographolide is the major active antihepatotoxic principle present in A. paniculata.
GSK3β is a new therapeutic target for myotonic dystrophy type 1 (2013)

Myotonic dystrophy type 1 (DM1), an incurable, neuromuscular disease, is caused by the expansion of CTG repeats within the 3' UTR of DMPK on chromosome 19q. In DM1 patients, mutant DMPK transcripts deregulate RNA metabolism by altering CUG RNA-binding proteins. Several approaches have been proposed for DM1 therapy focused on specific degradation of the mutant CUG repeats or on correction of RNA-binding proteins, affected by CUG repeats. One such protein is CUG RNA-binding protein (CUGBP1). The ability of CUGBP1 to increase or inhibit translation depends on phosphorylation at Ser302, which is mediated by cyclin D3-CDK4. The mutant CUG repeats increase the levels of CUGBP1 protein and inhibit Ser302 phosphorylation, leading to the accumulation of CUGBP1 isoforms that repress translation (i.e., CUGBP1(REP)). Elevation of CUGBP1(REP) in DM1 is caused by increased GSK3β kinase, which reduces the cyclin D3-CDK4 pathway and subsequent phosphorylation of CUGBP1 at Ser302. In this review, we discuss our recent discovery showing that correction of GSK3β activity in the DM1 mouse model (i.e., HSA(LR) mice) reduces DM1 muscle pathology. These findings demonstrate that GSK3β is a novel therapeutic target for treating DM1.
AIDS as immune system activation: a model for pathogenesis. (1988)

Epidemiological evidence has implicated the human immunodeficiency virus (HIV) as the etiological agent of the acquired immunodeficiency syndrome (AIDS) (Barré-Sinoussi et al., 1983; Sarngadharan et al., 1984; Kitchen et al., 1984; Levy et al., 1984). Primary infection with HIV is accompanied by an acute flu-like illness followed by a relatively long period of asymptomatic infection, the delayed appearance of lymphadenopathy and a progressive decline in immune responsiveness. Eventually, significant reduction in T4 cell number occurs along with susceptibility to a variety of opportunistic infections. It is generally accepted that this lymphotropic retrovirus causes the depletion of the helper class of T lymphocytes (T4) by direct cytopathic effects and/or the induction of autoimmune killing of T cells (Fauci, 1987). Few objections have been raised to this model despite abundant experimental evidence that viraemia and the number of infected T cells are limited and constant throughout disease progression (Levy et al., 1985; Shaw et al., 1984; Harper et al., 1986; Duesberg, 1987). We believe that the current model for HIV-induced pathology is unsatisfactory. A hypothesis is advanced in which progressive immunodeficiency is caused by indirect mechanisms without widespread T cell infection, direct virus-mediated cytopathic effects, or autoimmunity. We propose that the latency of AIDS is not due to delayed viral expression and growth but rather to the accumulation of insults to an immune system with abnormal regulatory mechanisms induced by HIV infection of macrophages.
Thermogenic response to epinephrine in the forearm and abdominal subcutaneous adipose tissue (1992)

Whole body energy expenditure, thermogenic and metabolic changes in the forearm, and intercellular glucose concentrations in subcutaneous adipose tissue on the abdomen determined by microdialysis were measured during epinephrine infusion in healthy subjects. After a control period, epinephrine was infused at rates of 0.2 and 0.4 nmol.kg-1 x min-1. Whole body resting energy expenditure was 4.36 +/- 0.56 (SD) kJ/min. Energy expenditure increased to 5.14 +/- 0.74 and 5.46 +/- 0.79 kJ/min, respectively (P < 0.001), during the epinephrine infusions. Respiratory exchange ratio was 0.80 +/- 0.04 in the resting state and did not change. Local forearm oxygen uptake was 3.9 +/- 1.3 mumol.100 g-1 x min-1 in the basal period. During epinephrine infusion, it increased to 5.8 +/- 2.1 (P < 0.03) and 7.5 +/- 2.3 mumol.100 g-1 x min-1 (P < 0.001). Local forearm glucose uptake was 0.160 +/- 0.105 mumol.100 g-1 x min-1 and increased to 0.586 +/- 0.445 and 0.760 +/- 0.534 mumol.100 g-1 x min-1 (P < 0.025). The intercellular glucose concentration in the subcutaneous adipose tissue on the abdomen was equal to the arterial concentration in the basal period but did not increase as much during infusion of epinephrine, indicating glucose uptake in adipose tissue in this condition. If it is assumed that forearm skeletal muscle is representative for the average skeletal muscle, it can be calculated that on average 40% of the enhanced whole body oxygen uptake induced by infusion of epinephrine is taking place in skeletal muscle. It is proposed that adipose tissue may contribute to epinephrine-induced thermogenesis.
Immunobinding assay for detection of Mycoplasma bovis in milk. (1990)

An immunobinding dot-blot assay (IBA) was developed for the detection of mycoplasma in milk. The test was highly species specific when monoclonal antibody preparations were employed in the assay system. Reactions were obtained with all mycoplasma species tested when polyclonal antisera preparations were used. Preincubation for 48-72 hours was necessary with milk samples containing only a few mycoplasma. Time from sample receipt to diagnosis in most positive samples could be reduced from several days by culture to a few hours by the IBA, thus enabling control procedures to be quickly initiated.