gebhart/patrepeval huggingface dataset:
Attenuation of Acute Graft-versus-Host Disease in the Absence of the Transcription Factor RORγt (2012)

Graft-versus-host disease (GVHD) remains the most significant complication after allogeneic stem cell transplantation. Previously, acute GVHD had been considered to be mediated predominantly by Th1-polarized T cells. Recently, investigators have identified a second proinflammatory lineage of T cells termed Th17 that is critically dependent on the transcription factor retinoic acid-related orphan receptor (ROR)γt. In this study, we have evaluated the role of Th17 cells in murine acute GVHD by infusing donor T cells lacking RORC and as a consequence the isoform RORγt. Recipients given donor CD4(+) and CD8(+) T cells lacking RORC had significantly attenuated acute GVHD and markedly decreased tissue pathology in the colon, liver, and lung. Using a clinically relevant haploidentical murine transplantation model, we showed that RORC(-/-) CD4(+) T cells alone diminished the severity and lethality of acute GVHD. This was not found when CD4(+) T cells from RORC(-/-) mice were given to completely mismatched BALB/c mice, and it was correlated with absolute differences in the generation of TNF in the colon after transplant. Thus, CD4(+) T cell expression of RORC is important in the pathogenesis of acute GVHD.
Content-based Video Information Retrieval and Streaming System using Viewpoint Invariant Regions (2009)

This paper caters the need of acquiring the principal objects, characters, and scenes from a video in order to entertain the image based query. The movie frames are divided into frames with 2D representative images called frames. Various regions in a key frame are marked as key objects according to their textures and shapes. These key objects serve as a catalogue of regions to be searched and matched from rest of the movie, using viewpoint invariant regions calculation, providing the location, size, and orientation of all the objects occurring in the movie in the form of a set of structures collaborating as video profile. The profile provides information about occurrences of every single key object from every frame of the movie it exists in. This information can further ease streaming of objects over various network-based viewing qualities. Hence, the method provides an effective reduced profiling approach of automatic logging and viewing information through query by example (QBE) procedure, and deals with video streaming issues at the same time.
Accurate small-signal model for an automotive bidirectional Dual Active Bridge converter (2008)

The derivation of an accurate small-signal model for a galvanically isolated, bidirectional DC-DC converter and the implementation of a corresponding controller on a digital signal processor (DSP) as well as key methods and functions required for the digital implementation are detailed in this paper. The investigated DC-DC converter, an automotive Dual Active Bridge (DAB) system enables power transfer between a low voltage port (ranging from 11 V to 16 V) and a high voltage port (240 V to 450 V). The nominal power rating is 2 kW. The developed small-signal model yields highly accurate results for the DAB system, but the proposed modelling procedure could also be applied to arbitrary resonant power converters with unidirectional or bidirectional power transfer.
The Effects of Different Culture Media on Human Corneal Endothelial Cells (2014)

Culture medium D was superior to the other media with regard to the expression of stem cell-associated proteins, proliferation, and cell migration. However, medium N was more appropriate than the other three media with regard to maintaining the proper cell shape and function.
Modalidades de transición profesional, mercado de trabajo y condiciones de empleo. (1997)

Sin resumen
Molecular Mechanisms of DNA Damage and Repair: Progress in Plants (2001)

Despite stable genomes of all living organisms, they are subject to damage by chemical and physical agents in the environment (e.g., UV and ionizing. radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. The DNA lesions produced by these damaging agents could be altered base, missing base, mismatch base, deletion or insertion, linked pyrimidines, strand breaks, intra- and inter-strand cross-links. These DNA lesions could be genotoxic or cytotoxic to the cell. Plants are most affected by the UV-B radiation of sunlight, which penetrates and damages their genome by inducing oxidative damage (pyrimidine hydrates) and cross-links (both DNA protein and DNA-DNA) that are responsible for retarding the growth and development. The DNA lesions can be removed by repair, replaced by recombination, or retained, leading to genome instability or mutations or carcinogenesis or cell death. Mostly organisms respond to genome damage by activating a DNA damage response pathway that regulates cell-cycle arrest, apoptosis, and DNA repair pathways. To prevent the harmful effect of DNA damage and maintain the genome integrity, all organisms have developed various strategies to either reverse, excise, or tolerate the persistence of DNA damage products by generating a network of DNA repair mechanisms. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. The direct reversal and photoreactivation require single protein, all the rest of the repair mechanisms utilize multiple proteins to remove or repair the lesions. The base excision repair pathway eliminates single damaged base, while nucleotide excision repair excises a patch of 25- to 32-nucleotide-long oligomer, including the damage. The double-strand break repair utilizes either homologous recombination or nonhomologous endjoining. In plant the latter pathway is more error prone than in other eukaryotes, which could be an important driving force in plant genome evolution. The Arabidopsis genome data indicated that the DNA repair is highly conserved between plants and mammals than within the animal kingdom, perhaps reflecting common factors such as DNA methylation. This review describes all the possible mechanisms of DNA damage and repair in general and an up to date progress in plants. In addition, various types of DNA damage products, free radical production, lipid peroxidation, role of ozone, dessication damage of plant seed, DNA integrity in pollen, and the role of DNA helicases in damage and repair and the repair genes in Arabidopsis genome are also covered in this review.
Eupatilin Inhibits Gastric Cancer Cell Growth by Blocking STAT3-Mediated VEGF Expression (2011)

Our results indicate that eupatilin inhibits angiogenesis in gastric cancer cells by blocking STAT3 and VEGF expression, suggesting its therapeutic potential in the treatment of gastric cancer.
[n]Staffanes: a molecular-size "Tinkertoy" construction set for nanotechnology. Preparation of end-functionalized telomers and a polymer of [1.1.1]propellane (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT[n]Staffanes: a molecular-size "Tinkertoy" construction set for nanotechnology. Preparation of end-functionalized telomers and a polymer of [1.1.1]propellanePiotr. Kaszynski and Josef. MichlCite this: J. Am. Chem. Soc. 1988, 110, 15, 5225–5226Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/ja00223a070https://doi.org/10.1021/ja00223a070research-articleACS PublicationsRequest reuse permissionsArticle Views987Altmetric-Citations120LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hardware-Assisted Two-Party Secure Computation on Mobile Devices (2013)

This thesis focuses on the practical realization of general two-party Secure Function Evaluation\nin a mobile environment and the possibility of enhancing these techniques by the use of a\ntrusted hardware token.\nSecure function evaluation allows multiple mutually distrusting parties to jointly compute\na function on their private inputs without revealing anything but the function output. This\ntechnique is particularly interesting in the context of mobile electronics, such as smartphones,\nwhere typically highly sensitive user data is stored and processed. The protection of this\ndata is desirable but very costly, due to the high complexity of secure computation protocols.\nImplementing Secure Function Evaluation schemes on smartphones is a challenging task due\nto their limitations in processing power, memory and battery-life.\nTo address these issues, we extended an existing two-party secure function evaluation scheme\nby a trusted hardware token that allows to securely pre-generate data, used in the actual\nfunction evaluation phase for masking sensitive values. For the purpose of securely distributing\ndata generated by the token, we designed and implemented a communication protocol based\non TLS on the smart card. We present working demonstrators for managing the hardware\ntoken and running secure two-party function evaluation on Android smart phones making\nuse of a microSD smart card. The use cases we implemented are private set intersection to\nfind shared contacts and securely scheduling a meeting. Our implementation is benchmarked\nand its performance is analyzed.
Transcervical embryo transfer in mice. (2014)

Although efficient transcervical transfer of embryos in mice would provide many advantages over a surgical method, the low success rate of transcervical transfer has hampered its acceptance and use. Here, we describe a novel device and protocol for transcervical embryo transfer in mice. Blastocysts from CD1 female mice were transferred into the uteri of 2.5-d pseudopregnant CD1 mice by using this method resulted in the successful development of 66.7% to 73.5% of the transferred blastocysts into live-born fetuses. Our method is as efficient as surgical embryo transfer yet is much simpler, easier, and markedly less traumatic to the recipient. In addition, our method provides hygienic and economic advantages and conforms to the principles of humane experimental technique. More importantly, our method provides a model for studying transcervical embryo transfer in cattle, other large animals, and humans.
Mushrooms as therapeutic agents (2011)

Mushrooms have been known for their nutritional and culinary values and used as medicines and tonics by humans for ages. In modern terms, they can be considered as functional foods which can provide health benefits beyond the traditional nutrients. There are monographs that cover the medicinal and healing properties of some individual traditional mushrooms. There has been a recent upsurge of interest in mushrooms not only as a health food which is rich in protein but also as a source of biologically active compounds of medicinal value which include complementary medicine/dietary supplements for anticancer, antiviral, hepatoprotective, immunopotentiating and hypocholesterolemic agents. However the mechanisms of the various health benefits of mushrooms to humans still require intensive investigation, especially given the emergence of new evidence of their health benefits. In the present paper the medicinal potential of mushrooms is being discussed.
<scp>PD</scp>‐1 as a potential target in cancer therapy (2013)

Recently, an improved understanding of the molecular mechanisms governing the host response to tumors has led to the identification of checkpoint signaling pathways involved in limiting the anticancer immune response. One of the most critical checkpoint pathways responsible for mediating tumor-induced immune suppression is the programmed death-1 (PD-1) pathway, normally involved in promoting tolerance and preventing tissue damage in settings of chronic inflammation. Many human solid tumors express PD ligand 1 (PD-L1), and this is often associated with a worse prognosis. Tumor-infiltrating lymphocytes from patients with cancer typically express PD-1 and have impaired antitumor functionality. Proof-of-concept has come from several preclinical studies in which blockade of PD-1 or PD-L1 enhanced T-cell function and tumor cell lysis. Three monoclonal antibodies against PD-1, and one against PD-L1, have reported phase 1 data. All four agents have shown encouraging preliminary activity, and those that have been evaluated in larger patient populations appear to have encouraging safety profiles. Additional data are eagerly awaited. This review summarizes emerging clinical data and potential of PD-1 pathway-targeted antibodies in development. If subsequent investigations confirm the initial results, it is conceivable that agents blocking the PD-1/PD-L1 pathway will prove valuable additions to the growing armamentarium of targeted immunotherapeutic agents.
Intention Detecting (1993)

Journal Article Intention Detecting Get access Richard Holton Richard Holton Monash University Search for other works by this author on: Oxford Academic Google Scholar The Philosophical Quarterly, Volume 43, Issue 172, July 1993, Pages 298–318, https://doi.org/10.2307/2219896 Published: 01 July 1993
Three-dimensional integration of optical multi-chips using surface-activated bonding for high-density microsystems packaging (2008)

The hybrid integration of multiple chips in three dimensions is an important technology for realizing highly functional, compact optoelectronic microsystems. In this study, three-dimensional integration of optical chips was successfully performed using Au-Au surface-activated bonding (bonding temperature: 150degC). The fabricated microsystem consists of two elements: i) a micromachined silicon optical bench incorporating a bonded laser diode, micromirrors, and through-hole electrodes; and ii) a glass substrate incorporating bonded photodiodes, electrical interconnections, and refractive microlenses. The silicon optical bench and the glass substrate were vertically stacked by surface-activated bonding. The size of the fully integrated microsystem is only 2.6 mm times 2.6 mm times 1 mm thick. The design and fabrication process allow chip-scale and wafer-level packaging. In addition, application for laser Doppler velocimeter sensor is discussed.
Industrial Light & Magic: Into the Digital Realm (1996)

A new decade at Industrial Light and Magic has brought us such movies as Terminator 2, Jurassic Park, The Mask, and Forrest Gump. Lavishly illustrated in full color throughout, this successor and companion to the bestselling ILM: The Art of Special Effects re-creates all the magic and technology of ILM's second groundbreaking decade.
Drilling with Rotary Steerable System Reduces Wellbore Tortuosity (2001)

Abstract Wellbore tortuosity can be defined as any unwanted deviation from the planned well trajectory. As wells become more complex, oil companies increasingly perceive wellbore tortuosity as a concern in the process of drilling, completing and producing wells. Tortuosity is a potential source of additional torque/drag and can lead to problems while running casing, liners and completions. In specific applications, excessive tortuosity in horizontal wells can even impair productivity. Due to the conceptual difference in steering principle between conventional directional drilling systems, utilizing steerable bent housing motor technology, and rotary steerable systems, it has been claimed that rotary steerable systems produce a less tortuous wellbore. This effect has so far not been quantified, mainly due to the absence of a sufficient body of comparative data. In this paper, results of a tortuosity analysis of a number of North Sea wells drilled with rotary steerable systems, and offset wells drilled with steerable motors systems is presented. Various mathematical definitions of wellbore tortuosity and their implications are also discussed. The analysis shows that drilling with rotary steerable systems significantly reduces tortuosity. In tangent sections drilled with the rotary steerable system, superior inclination hold performance was observed and in areas of the wellbore where deviation changes were planned, more continuous curve sections were drilled. In order to illustrate potential benefits this may have with respect to drilling conditions, results from the evaluation were used to carry out torque/drag simulations. Levels of tortuosity produced by steerable motor systems and rotary steerable systems were calculated from the well data studied. These values were superimposed on a generic well profile. It was found that the torque reducing effect of the lower tortuosity delivered by the rotary steerable system is quantifiable and in some cases significant.
A Convolutional Neural Network Fully Implemented on FPGA for Embedded Platforms (2017)

Convolutional Neural Networks (CNNs) allow fast and precise image recognition. Nowadays this capability is highly requested in the embedded system domain for video processing applications such as video surveillance and homeland security. Moreover, with the increasing requirement of portable and ubiquitous processing, power consumption is a key issue to be accounted for.In this paper, we present an FPGA implementation of CNN designed for addressing portability and power efficiency. Performance characterization results show that the proposed implementation is as efficient as a general purpose 16-core CPU, and almost 15 times faster than a SoC GPU for mobile application. Moreover, external memory footprint is reduced by 84% with respect to a standard CNN software application.
Regulatory T cells in human allergic disease (2004)

Allergic diseases are frequent and rising in prevalence, and result from activation of T-helper (Th) 2 cells by common environmental antigens (allergens).CD4+CD25+ regulatory T cells prevent pathology in many animal models of disease and human CD4+CD25+ regulatory T cells suppress T cell activation in vitro.However, at the commencement of this project there were few reports of suppression of Th2 responses by CD4+CD25+ regulatory T cells.This thesis therefore investigated the suppression of Th2-type T cell responses to allergen by human CD4+CD25+ regulatory T cells in vitro.The ability of regulatory T cells from atopic and non-atopic donors, to suppress allergen driven T cell responses was then compared.Finally, the effect of allergen immunotherapy treatment on the suppression of allergen driven T cell responses was investigated.Results from this thesis are among the first to describe the suppression of allergen driven T cell responses by human CD4+CD25+ regulatory T cells and fiirthermore were the first to relate suppression by CD4+CD25+ T cells with expression of allergic disease in humans.Such cells from non-atopic donors were able to suppress both proliferation and cytokine production by the allergen stimulated CD4+CD25-T cell subset.Inhibition of proliferation by CD4+CD25+ T cells from atopic donors was significantly reduced.Suppression was further diminished when CD4+CD25+ T cells were isolated from grass pollen allergic patients during the hayfever season.Data from this thesis has also shown that effective allergen immunotherapy treatment is not associated with an increase in the ability of CD4+CD25+ T cells to suppress Th2 responses.However, a separate novel population of IL-10 secreting T cells within the CD4+CD25-subset did suppress Th2 responses more effectively when isolated from atopic donors who had received allergen immunotherapy treatment compared to those from untreated atopic individuals.The data presented here suggests that allergic disease may result in part from an inbalance between allergen activation of regulatory CD4+CD25+ T cells and effector Th2 cells.Treatment to enhance regulatory T-cell responses, in concert with reducing Th2 cell activation, may be beneficial in the prevention and treatment of allergic disease.Chapter 3 -The suppression of in vitro allergen stimulated T cell responses by human CD4+CD25+ regulatory T cells 4.3.4.The suppression by CD4+CD25+ T cells from atopic donors of T cell responses to antigens which drive a Thl response and allergens to which they do not make specific IgE 4.3.5.ConclusionChapter 5 -The role of regulatory T cells in allergen immunotherapy treatment....
Overexpression of factor VIII after AAV delivery is transiently associated with cellular stress in hemophilia A mice (2016)

Factor VIII (FVIII) is a large glycoprotein that is challenging to express both <i>in vitro</i> and <i>in vivo</i>. Several studies suggest that high levels of FVIII expression can lead to cellular stress. After gene transfer, transgene expression is restricted to a subset of cells and the increased FVIII load per cell may impact activation of the unfolded protein response. We sought to determine whether increased FVIII expression in mice after adeno-associated viral liver gene transfer would affect the unfolded protein response and/or immune response to the transgene. The FVIII gene was delivered as B-domain deleted single chain or two chain (light and heavy chains) at a range of doses in hemophilia A mice. A correlation between FVIII expression and anti-FVIII antibody titers was observed. Analysis of key components of the unfolded protein response, binding immunoglobulin protein (BiP), and C/EBP homologous protein (CHOP), showed transient unfolded protein response activation in the single chain treated group expressing >200% of FVIII but not after two chain delivery. These studies suggest that supraphysiological single chain FVIII expression may increase the likelihood of a cellular stress response but does not alter liver function. These data are in agreement with the observed long-term expression of FVIII at therapeutic levels after adeno-associated viral delivery in hemophilia A dogs without evidence of cellular toxicity.
Polarography of Copper (II)-(I) Cysteamine-Cystamine Systems (1971)

Abstract The polarography of copper(II) and copper(I) in acetonitrile-water mixtures, to which cysteamine or cystamine was added, has been studied. Copper(II) is rapidly reduced to copper(I) by cysteamine. Copper(I) forms several complexes with cystamine and cysteamine including Cu2(S-CH2-CH2-NH2).
ChemInform Abstract: Peptides That Contain Unnatural Amino Acids: Toward Artificial Proteins (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Herpes simplex virus oncolytic vaccine therapy in melanoma (2010)

JSI/34.5-/47-/GM-CSF is a new generation herpes simplex virus-1 oncolytic vaccine that demonstrates direct tumor lysis and systemic immune responses. Early clinical studies have yielded preliminary evidence of activity.