gebhart/patrepeval huggingface dataset:
Functional Domains of the Transcription Factor USF2: Atypical Nuclear Localization Signals and Context-Dependent Transcriptional Activation Domains (1996)

USF is a family of basic helix-loop transcriptional factors that recognizes DNA-binding sites similar to those of the Myc oncoproteins. Here, various functional domains in the mouse USF2 protein were identified and characterized. Indirect immunofluorescence studies with transiently transfected cells revealed that both the basic region and the highly conserved USF-specific region (USR) are involved in the nuclear localization of USF2. Cotransfection assays with deletion mutants containing the DNA-binding domain of either USF2 or GAL4 identified two distinct transcriptional activation domains in USF2, the USR and the exon 5-encoded region. Activity of the exon 5 activation domain was detectable in both assay systems. Within USF2, however, its potency varied with the conformation induced by the surrounding regions, especially that encoded by alternatively spliced exon 4. In contrast, the USR activated transcription only in its natural context upstream of the USF2 basic region and only with reporter constructs containing the adenovirus major late minimal promoter but not the E1b minimal promoter. However, insertion of an initiator element downstream of the TATA box rescued the activity of the USR on the E1b-driven reporters. The USR therefore represents a new type of activation domain whose function depends very strongly on the core promoter context.
A novel low complexity multichannel Cosine Modulated Filter Bank using IFIR technique for Nearly Perfect Reconstruction (2012)

This paper presents a design of low-complexity multichannel Nearly Perfect Reconstruction (NPR) Cosine Modulated Filter Bank (CMFB). CMFBs are used extensively because of the ease implementation and they have the advantage of high stopband attenuation. But this leads to certain limitations because it would require large number of filter coefficients and longer delays when the number of channels is more e.g. 32-band or 64-band CMFB. Large number of filter coefficients would imply that increased computational complexity. Here the prototype filter is designed using interpolated finite impulse response (IFIR) technique. The stretched factor is chosen in such a way so that computational cost will be reduced and minimizes the value of error parameters. The IFIR approach leads to reduction in stopband energy as well as Side-Lobe-Fall-off-Rate (SLFOR) in magnitude response of the prototype filter. One example has been included to illustrate the effectiveness of the proposed technique over the existing design methods. Here, an earlier approach to prototype filter design based on the Kaiser window is implemented using an IFIR approach. Savings in computational complexity and improvement in performance with respect to the previous works are shown.
Copy Number Variants in Extended Autism Spectrum Disorder Families Reveal Candidates Potentially Involved in Autism Risk (2011)

Copy number variations (CNVs) are a major cause of genetic disruption in the human genome with far more nucleotides being altered by duplications and deletions than by single nucleotide polymorphisms (SNPs). In the multifaceted etiology of autism spectrum disorders (ASDs), CNVs appear to contribute significantly to our understanding of the pathogenesis of this complex disease. A unique resource of 42 extended ASD families was genotyped for over 1 million SNPs to detect CNVs that may contribute to ASD susceptibility. Each family has at least one avuncular or cousin pair with ASD. Families were then evaluated for co-segregation of CNVs in ASD patients. We identified a total of five deletions and seven duplications in eleven families that co-segregated with ASD. Two of the CNVs overlap with regions on 7p21.3 and 15q24.1 that have been previously reported in ASD individuals and two additional CNVs on 3p26.3 and 12q24.32 occur near regions associated with schizophrenia. These findings provide further evidence for the involvement of ICA1 and NXPH1 on 7p21.3 in ASD susceptibility and highlight novel ASD candidates, including CHL1, FGFBP3 and POUF41. These studies highlight the power of using extended families for gene discovery in traits with a complex etiology.
Adapt-a-ride (2011)

Solo driving is the number one commuting choice for a majority of the people in the United States despite its high costs, stressful traffic congestions, and impact on environment. Existing industry attempting to bring alternative transportation choices, fall short reaching critical mass to survive. In this work, we focus both on the issues of solo driving and why industry might be falling short understanding the dynamics of commuting preferences. We followed an innovative experience design framework to shape our user centered design processes and identified the underlying dynamics of flexibility, cost and personal preference as three driving themes affecting people's commuting choices. We have then designed and evaluated a concept design for an interactive system that manifested these themes, and reported our findings and design implications on how to facilitate behavioral change through design. Our primary finding is that people's flexibility preferences change when a system offers them concrete scenarios.
Behavior of Halogenated Nitrobenzenes with β-Diketones. II. 6-Nitroanthranil from 2,4-Dinitrophenylacetone (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBehavior of Halogenated Nitrobenzenes with β-Diketones. II. 6-Nitroanthranil from 2,4-DinitrophenylacetoneS. S. JOSHI and I. R. GAMBHIRCite this: J. Org. Chem. 1961, 26, 10, 3714–3717Publication Date (Print):October 1, 1961Publication History Published online1 May 2002Published inissue 1 October 1961https://pubs.acs.org/doi/10.1021/jo01068a023https://doi.org/10.1021/jo01068a023research-articleACS PublicationsRequest reuse permissionsArticle Views73Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sol–gel epitaxial growth of La1−<i>x</i>Ca<i>x</i>MnO3 with colossal magnetoresistance effect (1996)

The successful sol–gel growth of colossal magnetoresistive La-Ca-Mn-O powder and epitaxial thin film is reported. Homogeneous powders were prepared at a temperature of 315 °C and epitaxial thin films were obtained on MgO(100) and LaAlO3(100) through heat treatment at 700–950 °C. A transition from semiconductor (negative dρ/dT) to metal (positive dρ/dT) was observed at 225 K, which was located in proximity to the magnetic transition temperature (Tc) of 228 K. A peak magnetoresistance ratio of ∼900% occurred at 220 K.
Isolation and Characterization of New Fission Yeast Cytokinesis Mutants (1998)

Schizosaccharomyces pombe is an excellent organism in which to study cytokinesis as it divides by medial fission using an F-actin contractile ring. To enhance our understanding of the cell division process, a large genetic screen was carried out in which 17 genetic loci essential for cytokinesis were identified, 5 of which are novel. Mutants identifying three genes, rng3(+), rng4(+), and rng5(+), were defective in organizing an actin contractile ring. Four mutants defective in septum deposition, septum initiation defective (sid)1, sid2, sid3, and sid4, were also identified and characterized. Genetic analyses revealed that the sid mutants display strong negative interactions with the previously described septation mutants cdc7-24, cdc11-123, and cdc14-118. The rng5(+), sid2(+), and sid3(+) genes were cloned and shown to encode Myo2p (a myosin heavy chain), a protein kinase related to budding yeast Dbf2p, and Spg1p, a GTP binding protein that is a member of the ras superfamily of GTPases, respectively. The ability of Spg1p to promote septum formation from any point in the cell cycle depends on the activity of Sid4p. In addition, we have characterized a phenotype that has not been described previously in cytokinesis mutants, namely the failure to reorganize actin patches to the medial region of the cell in preparation for septum formation.
Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man. (1976)

The conjugation of glycine to benzoates and the conjugation of L-glutamine to certain arylacetates are catalyzed by two different acyl-CoA:amino acid N-acyltransferases which can be purified separately from liver mitochondrial fractions of either rhesus monkey or man. In both species, one transferase is specific for glycine and the other for L-glutamine. The glycine enzyme utilizes either butyryl-CoA or benzoyl-CoA as acyl donors while the glutamine enzyme uses either phenylacetyl-CoA or indoleacetyl-CoA. Acyl-CoA substrates for one transferase do not serve as substrates for the other. Additional studies with the monkey liver enzymes revealed that acyl-CoA substrates for one transferase inhibit the other, that the apparent Km value is low (10(-6) to 10(-5) M range) for the preferred acyl-CoA substrate as compared to the amino acid acceptor (greater than 10(-2) M) and that both transferases have a molecular weight of approximately 24,000. Hippuric acid and either phenylacetylglutamine or indoleacetylglutamine were characterized as the products formed by the separate enzymes.
Interleaved frequency division multiple access for upstream transmission of next-generation PON (2011)

Interleaved frequency division multiple access (IFDMA) for upstream transmission of next-generation passive optical network is experimentally demonstrated. The scheme has low PAPR and low computation complexity for ONU transmitters.
General Methods of Synthesis of Indole Alkaloids. IV. A Synthesis of dl-Eburnamonine<sup>1,2</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneral Methods of Synthesis of Indole Alkaloids. IV. A Synthesis of dl-Eburnamonine1,2Ernest Wenkert and Börje WickbergCite this: J. Am. Chem. Soc. 1965, 87, 7, 1580–1589Publication Date (Print):April 1, 1965Publication History Published online1 May 2002Published inissue 1 April 1965https://pubs.acs.org/doi/10.1021/ja01085a029https://doi.org/10.1021/ja01085a029research-articleACS PublicationsRequest reuse permissionsArticle Views1138Altmetric-Citations147LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Job‐Shop Scheduling Problems (1996)

This chapter contains sections titled: Introduction Classical Job-Shop Model Conventional Heuristics Genetic Algorithms for Job-Shop Scheduling Problems Gen, Tsujimura, and Kubota's Approach Cheng, Gen, and Tsujimura's Approach Falkenauer and Bouffouix's Approach Dorndorf and Pesch's Approach Computational Results and Discussion
An integrated high availability computing platform (2005)

Purpose – To recommend an integrated server platform and demonstrate a real‐world example that provides high availability (HA) and better data management to meet various systems' computing needs.
Evaluation of layered structures for micromachines by means of ultrasonic micro-spectroscopy (1994)

Elastic properties of Si-B-O glass layers fabricated on (100) Si substrates by the flame hydrolysis deposition method were measured. Thicknesses of the layers were about 20 μm. The longitudinal velocity of the layers was measured by ultrasonic spectroscopy of normal incidence covering the frequency range from 100 MHz to 300 MHz. Frequency dispersion of the Rayleigh wave velocity was also measured by means of an ultrasonic microspectrometer. It was found that the Young's modulus decreased with the boron dopant concentration, while the Poisson's ratio was about 0.26 regardless of the boron dopant concentration. The measured elastic properties will be used in the design of micromachines fabricated with Si substrates and glass layers
Mercury Binding Sites in Thiol-Functionalized Mesostructured Silica (2005)

Thiol-functionalized mesostructured silica with anhydrous compositions of (SiO(2))(1)(-)(x)()(LSiO(1.5))(x)(), where L is a mercaptopropyl group and x is the fraction of functionalized framework silicon centers, are effective trapping agents for the removal of mercuric(II) ions from water. In the present work, we investigate the mercury-binding mechanism for representative thiol-functionalized mesostructures by atomic pair distribution function (PDF) analysis of synchrotron X-ray powder diffraction data and by Raman spectroscopy. The mesostructures with wormhole framework structures and compositions corresponding to x = 0.30 and 0.50 were prepared by direct assembly methods in the presence of a structure-directing amine porogen. PDF analyses of five mercury-loaded compositions with Hg/S ratios of 0.50-1.30 provided evidence for the bridging of thiolate sulfur atoms to two metal ion centers and the formation of chain structures on the pore surfaces. We find no evidence for Hg-O bonds and can rule out oxygen coordination of the mercury at greater than the 10% level. The relative intensities of the PDF peaks corresponding to Hg-S and Hg-Hg atomic pairs indicate that the mercury centers cluster on the functionalized surfaces by virtue of thiolate bridging, regardless of the overall mercury loading. However, the Raman results indicate that the complexation of mercury centers by thiolate depends on the mercury loading. At low mercury loadings (Hg/S < or = 0.5), the dominant species is an electrically neutral complex in which mercury most likely is tetrahedrally coordinated to bridging thiolate ligands, as in Hg(SBu(t))(2). At higher loadings (Hg/S 1.0-1.3), mercury complex cations predominate, as evidenced by the presence of charge-balancing anions (nitrate) on the surface. This cationic form of bound mercury is assigned a linear coordination to two bridging thiolate ligands.
From federated learning to federated neural architecture search: a survey (2021)

Abstract Federated learning is a recently proposed distributed machine learning paradigm for privacy preservation, which has found a wide range of applications where data privacy is of primary concern. Meanwhile, neural architecture search has become very popular in deep learning for automatically tuning the architecture and hyperparameters of deep neural networks. While both federated learning and neural architecture search are faced with many open challenges, searching for optimized neural architectures in the federated learning framework is particularly demanding. This survey paper starts with a brief introduction to federated learning, including both horizontal, vertical, and hybrid federated learning. Then neural architecture search approaches based on reinforcement learning, evolutionary algorithms and gradient-based are presented. This is followed by a description of federated neural architecture search that has recently been proposed, which is categorized into online and offline implementations, and single- and multi-objective search approaches. Finally, remaining open research questions are outlined and promising research topics are suggested.
디지털원주민 Z세대에 대한 대학선교방안 모색 (2020)

본 논문의 목적은 기술발전으로 인한 기독교 대학교육의 변화된 환경에서 Z세대 대학생들에 대한 선교 방안을 탐구하는 것이다. 즉 Z세대는 누구이고 이들의 문화에 대응하는 선교는 어떻게 추구되어야 하는가를 살펴보는 것이다. 이를 위해 본 논문은 현대 사회과학에서 통용되고 있는 세대 분류연구에서 Z세대의 위치 및 문화적 특징을 살펴보고 이에 대응하는 선교방안을 모색했다. 본 논문은 Z세대 문화의 특징으로 부모와의 좋은 관계, 또래의 영향력이 큰 세대, 평등과 공정의 가치관을 추구하는 세대라 규정했다. 즉, 젊은 세대로서 평등과 공정, 다양성 등 진보적인 가치관을 선호하고 타 세대에 비해 또래의 영향력이 크지만 양육과정에서 부모의 긍정적 영향도 크기 때문에 노력을 통한 성공추구 등 보수적인 사고도 가지고 있다는 것이다. 대학선교는 이러한 Z세대 문화를 고려하여 선교의 방법을 추구하고 Z세대가 기독교 복음을 통해 새로운 가능성과 희망을 찾을 수 있도록 도와주어야 한다.
Age-dependent decrease of synaptic plasticity in the neocortex of αCaMKII mutant mice (1997)

Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking alpha-calcium/calmodulin-dependent protein kinase II (alphaCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial LTD and LTP were induced in 4- to 5-week-old mutants. Thus, the reduction in cortical plasticity in alphaCaMKII (-/-) mice is conditional, with the relevant condition being postnatal age.
Pressure swing adsorption: An experimental study of diffusion‐induced separation (1988)

Abstract Gas separation based on differences in intraparticle diffusion rates was achieved by four‐step pressure swing adsorption (PSA) process. The application studied was the separation of nitrogen from air using molecular sieve type RS‐10. Systematic PSA experiments were conducted in bench‐scale equipment to study several variables, including duration of steps of the cycle, flow rates, pressure ratio, subatmospheric blowdown and purge, and column geometry. The test results were compared with predictions of a mathematical model (Shin and Knaebel, 1987). In all cases, the trends of product purity and net recovery of both theory and experiment were in close agreement. Since the theory accurately portrays the overall behavior of the process, the transport mechanisms embodied in the theory may provide insight into diffusion‐induced separation by PSA. In addition, by reviewing the results of the parametric studies of the variables, it has been possible to gain an intuitive understanding of the relations between factors that affect each step, and hence overall performance.
Controlled External Powering of Miniaturized Chronically Implanted Biotelemetry Devices (1976)

Radio frequency energizing of implanted transmitters presents an interesting possibility to make feasible comparative measurements from sites within the body over very long periods of time. Disturbances in the energy transport may, however, cause the implant carrier frequency to change, which is seen as artifacts or drift at the demodulator end. Here, this problem was solved by feeding back the demodulator output level to control the amplitude of the external energizing oscillator. The closed loop modifies the frequency characteristic of the transmitter-receiver system in a predictable way. The artifacts due to implant movements can be minimized by careful application and by analysis of the field characteristics inside and outside the energizing solenoid, thus positioning the implant adequately.
Influence of caffeine on development of benign and carcinomatous mammary gland tumors in female rats treated with the carcinogens 7,12-dimethylbenz(a)anthracene and N-methyl-N-nitrosourea. (1991)

The effect of chronic caffeine consumption (500 mg/liter of drinking water) on the initiation and promotion stages of 7,12-dimethylbenz(a)anthracene (DMBA) (a low dose, 0.5 mg/100 g body weight, i.v.) and N-methyl-N-nitrosourea (MNU) (a standard dose, 2.5 mg/100 g body weight, i.v.) induced mammary gland tumorigenesis in female Sprague-Dawley rats was determined. In the initiation studies, caffeine was administered for 30 days prior to and for 3-4 days after carcinogen treatment (carcinogens administered at 55-57 days of age); in the promotion studies, caffeine was administered beginning 3-4 days after carcinogen treatment and until experiment termination (DMBA study and MNU study, 48 and 26 weeks after carcinogen treatment, respectively). In the DMBA study, there were 62-73 rats/group, in the MNU study, 40 rats/group. Eighty-nine % of the mammary tumors induced by DMBA were benign (adenomas, fibroadenomas, often with cystic secretory activity), 11% were carcinomas (intraductal and invasive); virtually all of the MNU-induced mammary tumors were carcinomas (approximately 99%). Caffeine consumption during the initiation stage in the DMBA-treated rats resulted in a significant decrease in the mean number of mammary carcinomas per rat (50% reduction, P less than 0.01) and mean number of benign mammary tumors per rat (28% reduction, P less than 0.05); caffeine consumption during the promotion stage significantly decreased the mean number of benign mammary tumors per rat (57% reduction, P less than 0.001) while not significantly influencing mammary carcinoma number. In contrast, caffeine consumption during either the initiation or promotion stages of MNU-treated rats did not significantly influence this tumorigenic process. The influence of caffeine on urinary and fecal excretion of tritiated DMBA and on rat mammary gland development at the time of carcinogen treatment also was determined. Slightly reduced levels of tritium in 24-h urinary samples were observed in caffeine-treated animals (P = 0.06). No significant effect of caffeine on 24- to 96-h fecal or 48- to 96-h urinary excretion of the isotope was observed. No apparent effect of caffeine on rat mammary gland development (number of ducts, degree of lobuloalveolar development) was observed. That caffeine significantly suppresses the initiation stage of DMBA-induced rat mammary gland tumorigenesis, while not influencing this stage when MNU is used as a carcinogen, suggests that caffeine acts via an alteration in carcinogen (DMBA) activation. The lack of a pronounced effect of caffeine on tritiated DMBA excretion, however, does cast some doubt on this mechanism.(ABSTRACT TRUNCATED AT 400 WORDS)
Progression and effect of cognitive-behavioral changes in patients with amyotrophic lateral sclerosis (2017)

Cognitive-behavioral change is a key aspect of disease heterogeneity in ALS. Executive function in ALS overall remains stable over 7 months as detected by an administered screening tool. However, patients may develop caregiver-reported behavioral symptoms in that time period. Screening for caregiver-reported symptoms has a particular utility in predicting future clinical decline, increased caregiver burden, and worsening patient QOL.
Five‐year lung cancer survival (2010)

Despite aggressive multimodality therapy, 5-year survival in patients with advanced stage NSCLC was very poor and limited to small pathological subsets. Patients with advanced stage NSCLC who did not belong to 1 of these subsets had a small chance of long-term survival.
An automatic and sterilizable sampler for laboratory fermentors: Application to the on‐line control of glucose concentration (1986)

Abstract No Absract.