gebhart/patrepeval huggingface dataset:
Platelet activation by thrombin can be directly measured in whole blood through the use of the peptide GPRP and flow cytometry (1994)

The role of platelet activation in clinical settings is controversial, partly because the methods used to detect platelet activation (e.g. platelet aggregation and radioimmunoassays of plasma beta-thromboglobulin and platelet factor 4) are plagued by major methodological problems. Clinical studies that utilize flow cytometric assays of washed platelets are also susceptible to artefactual in vitro platelet activation. Whole blood flow cytometry circumvents many of these methodological problems. However, a major limitation in previously described whole blood flow cytometric assays is their inability to study the effect on platelet activation of thrombin, the most important platelet agonist in vivo. This article reviews the method and clinical applications of a new flow cytometric assay in which platelet activation by thrombin is directly measured in whole blood through the use of the peptide Gly-Pro-Arg-Pro (GPRP). GPRP inhibits thrombin-induced fibrin clot formation and platelet aggregation, but not thrombin-induced platelet activation. The presently described assay of platelet activation by thrombin in the physiological milieu of whole blood should be widely applicable to the many clinical settings (e.g. arterial thrombosis) in which platelet activation by thrombin is postulated to play an important role.
The NMR Structure of Human β-Defensin-2 Reveals a Novel α-Helical Segment<sup>,</sup> (2001)

Human beta-defensin-2 (HBD-2) is a member of the defensin family of antimicrobial peptides. HBD-2 was first isolated from inflamed skin where it is posited to participate in the killing of invasive bacteria and in the recruitment of cells of the adaptive immune response. Static light scattering and two-dimensional proton nuclear magnetic resonance spectroscopy have been used to assess the physical state and structure of HBD-2 in solution. At concentrations of < or = 2.4 mM, HBD-2 is monomeric. The structure is amphiphilic with a nonuniform surface distribution of positive charge and contains several key structural elements, including a triple-stranded, antiparallel beta-sheet with strands 2 and 3 in a beta-hairpin conformation. A beta-bulge in the second strand occurs at Gly28, a position conserved in the entire defensin family. In solution, HBD-2 exhibits an alpha-helical segment near the N-terminus that has not been previously ascribed to solution structures of alpha-defensins or to the beta-defensin BNBD-12. This novel structural element may be a factor contributing to the specific microbicidal or chemokine-like properties of HBD-2.
Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial (2005)

Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 x 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated.
Chain transfer in ethylene polymerization. IV. Additional study at 1360 atm and 130°C (1970)

Abstract The previously reported chain‐transfer studies were extended to include chain transfer to esters, amides, amines, phosphines, and other compounds containing functional groups. Phosphines are very reactive, amines are moderately reactive, and amides and esters are quite unreactive. Most other functional groups give moderate reactivity. Halogens and compounds containing a nitrogen‐oxygen bond were all found to be inhibitors for ethylene polymerization.
Palladium-Catalyzed C,N-Cross Coupling Reactions of 3<i>-</i>Halo-2-aminopyridines (2011)

A simple approach toward N(3)-substituted-2,3-diaminopyridines is presented, based on Pd-catalyzed C,N-cross coupling. The use of RuPhos- and BrettPhos-precatalysts in combination with LiHMDS allows for C,N-cross coupling reactions of unprotected 3-halo-2-aminopyridines with primary and secondary amines.
Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer (2016)

The successes achieved by chimeric antigen receptor-modified T (CAR-T) cells in hematological malignancies raised the possibility of their use in non-small lung cancer (NSCLC). In this phase I clinical study (NCT01869166), patients with epidermal growth factor receptor (EGFR)-positive (>50% expression), relapsed/refractory NSCLC received escalating doses of EGFR-targeted CAR-T cell infusions. The EGFR-targeted CAR-T cells were generated from peripheral blood after a 10 to 13-day in vitro expansion. Serum cytokines in peripheral blood and copy numbers of CAR-EGFR transgene in peripheral blood and in tissue biopsy were monitored periodically. Clinical responses were evaluated with RECIST1.1 and immune- related response criteria, and adverse events were graded with CTCAE 4.0. The EGFR-targeted CAR-T cell infusions were well-tolerated without severe toxicity. Of 11 evaluable patients, two patients obtained partial response and five had stable disease for two to eight months. The median dose of transfused CAR(+) T cells was 0.97×10(7) cells kg(-1) (interquartile range (IQR), 0.45 to 1.09×10(7) cells kg(-1)). Pathological eradication of EGFR positive tumor cells after EGFR-targeted CAR-T cell treatment can be observed in tumor biopsies, along with the CAR-EGFR gene detected in tumor-infiltrating T cells in all four biopsied patients. The EGFR-targeted CAR-T cell therapy is safe and feasible for EGFR-positive advanced relapsed/refractory NSCLC.
Diradical polymerization of acrylonitrile initiated by ethyl 1-cyano-2-(p-methoxyphenyl)cyclopropanecarboxylate (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiradical polymerization of acrylonitrile initiated by ethyl 1-cyano-2-(p-methoxyphenyl)cyclopropanecarboxylateTong Li, T. J. Willis, Anne Buyle Padias, and H. K. Hall Jr.Cite this: Macromolecules 1991, 24, 9, 2485–2487Publication Date (Print):April 29, 1991Publication History Published online1 May 2002Published inissue 29 April 1991https://pubs.acs.org/doi/10.1021/ma00009a053https://doi.org/10.1021/ma00009a053research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Perfluoroalkylzinc Compounds. I. The Preparation and Properties of Perfluoroalkylzinc Halides<sup>1,2</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPerfluoroalkylzinc Compounds. I. The Preparation and Properties of Perfluoroalkylzinc Halides1,2William T. Miller Jr., Elliot Bergman, and Arnold H. FainbergCite this: J. Am. Chem. Soc. 1957, 79, 15, 4159–4164Publication Date (Print):August 1, 1957Publication History Published online1 May 2002Published inissue 1 August 1957https://doi.org/10.1021/ja01572a048Request reuse permissionsArticle Views386Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (884 KB) Get e-Alertsclose Get e-Alerts
Application of Social Network Analysis in Information Science (2008)

There are different levels to apply social network analysis(SNA)in information science.By analysing co-author papers,author cooperation degree of areas or institutes can be found.Through tracking a team work,stability and change can be found.In comparing co-words between researchers,we can mine deep relational network behind real relational network.Using citations network,we can track the processes of knowledge accumulate and discovery,evaluate paper and author.In this paper, Chinese information science is analysed by using SNA.Some rules and phenomena,that difficuh to be found by traditional methods,are found in the paper cooperation network.
Identification of the gp67 gene of a baculovirus pathogenic to the spruce budworm, Choristoneura fumiferana multinucleocapsid nuclear polyhedrosis virus (1994)

The baculovirus gp67 gene encodes a pH-dependent membrane fusion protein and has been identified in both Autographa californica multinucleocapsid nuclear polyhedrosis virus (AcMNPV) and Orygia pseudotsugata MNPV (OpMNPV). We have identified a homologous gene in the spruce budworm virus, Choristoneura fumiferana MNPV (CfMNPV). The CfMNPV gp67 gene is 79% identical to AcMNPV gp67 at the level of nucleotide sequence and 82% identical at the level of predicted amino acid sequence. As with OpMNPV and AcMNPV gp67, the CfMNPV gp67 protein is found exclusively in the budded virus phenotype of the baculovirus.
Assessment of Scoliosis Using Three-Dimensional Analysis (1981)

A computerized radiographic method is described for assessing scoliosis. Three radiographs of the spine are exposed using a specially constructed device to fix the positions of the films and the patient. Computer-generated color graphics displays are utilized to present objective and subjective information to the user. The system was validated by using phantoms and it is currently implemented in the clinic, where it is being used to obtain reconstructions of the spine and other spinal data.
Elastic, silk-cardiac extracellular matrix hydrogels exhibit time-dependent stiffening that modulates cardiac fibroblast response (2016)

Heart failure is the leading cause of death in the United States and rapidly becoming the leading cause of death worldwide. While pharmacological treatments can reduce progression to heart failure following myocardial infarction, there still exists a need for new therapies that promote better healing postinjury for a more functional cardiac repair and methods to understand how the changes to tissue mechanical properties influence cell phenotype and function following injury. To address this need, we have optimized a silk-based hydrogel platform containing cardiac tissue-derived extracellular matrix (cECM). These silk-cECM hydrogels have tunable mechanical properties, as well as rate-controllable hydrogel stiffening over time. In vitro, silk-cECM scaffolds led to enhanced cardiac fibroblast (CF) cell growth and viability with culture time. cECM incorporation improved expression of integrin an focal adhesion proteins, suggesting that CFs were able to interact with the cECM in the hydrogel. Subcutaneous injection of silk hydrogels in rats demonstrated that addition of the cECM led to endogenous cell infiltration and promoted endothelial cell ingrowth after 4 weeks in vivo. This naturally derived silk fibroin platform is applicable to the development of more physiologically relevant constructs that replicate healthy and diseased tissue in vitro and has the potential to be used as an injectable therapeutic for cardiac repair. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 3058-3072, 2016.
A new PWM strategy for common mode voltage reduction in neutral-point clamped inverter-fed AC motor drives (2000)

In this paper, the relationship between common mode voltage and switching states in neutral-point clamped (NPC) inverters is clarified, and a new pulse-width modulation (PWM) strategy for reducing the common mode voltage in NPC inverter-fed AC motor drives is proposed. Among total twenty seven switching states in NPC inverter, the proposed PWM uses only nineteen switching states that generates common mode voltage of which magnitude is same or less than one-sixth of DC bus voltage. Moreover, the proposed PWM strategy satisfies the constraint such that the output voltage vector should be changed by only one switching action. Not requiring extra hardware, the NPC inverter with the proposed PWM results in the remarkable reduction in peak-to-peak of common mode voltage, compared to two-level inverter and NPC inverter controlled by conventional PWM. The proposed PWM strategy can be easily implemented in software without degradation of control performance in AC motor drives.
Bayesian Network Models for Adaptive Testing (2015)

Computerized adaptive testing (CAT) is an interesting and promising approach to testing human abilities. In our research we use Bayesian networks to create a model of tested humans. We collected data from paper tests performed with grammar school students. In this article we first provide the summary of data used for our experiments. We propose several different Bayesian networks, which we tested and compared by cross-validation. Interesting results were obtained and are discussed in the paper. The analysis has brought a clearer view on the model selection problem. Future research is outlined in the concluding part of the paper.
Cross-protection against Microvariants of Influenza Virus Type B by Vaccinia Viruses Expressing Haemagglutinins from Egg- or MDCK Cell-derived Subpopulations of Influenza Virus Type B/England/222/82 (1989)

B/Singapore/222/79-like influenza viruses isolated from three patients during the winter of 1981 to 1982 and cultured in either embryonated hens' eggs or MDCK cells were studied. Sequence analysis indicated that the haemagglutinin (HA) genes of the six virus preparations contained at least four distinct HA1 sequences which differed by up to six amino acids. Only one pair of viruses had amino acid differences between the egg- and MDCK cell-derived viral subpopulations and this change did not affect a glycosylation site. Mice infected with previously described recombinant vaccinia viruses expressing either the egg- or MDCK cell-derived HA of B/England/222/82 developed neutralizing antibodies against all of the 1982 type B viruses and were protected against intranasal challenge with these viruses. Therefore, in this model system, the minor sequence variation between the HAs of egg- and MDCK cell-derived influenza B/England/222/82 virus had no detectable effect on the induction of cross-protection.
An integrated workflow to perform reservoir and completion parametric study on a shale gas reservoir (2020)

Abstract The main objectives of this paper are to assess the long-term and short-term production based on both reservoir parameters and completion parameters of shale gas reservoirs. The effects of the reservoir parameters (permeability and the initial reservoir pressure) and completion parameters (fracture geometry, stimulated reservoir volume, etc.) on the short-term and long-term production of shale gas reservoirs were investigated. The currently used approach relies mainly on the decline curve analysis or analogs from a similar shale play to forecast the gas production from shale gas reservoirs. Both these approaches are not satisfactory because they are calibrated on short production history and do not assess the impact of uncertainty in reservoir and well data. For the first time, this study integrates initial production analysis, probabilistic evaluation, and sensitivity analysis to develop a robust workflow that will help in designing a sustainable production from shale gas plays. The reservoir and completion parameters were collected from different available resources, and the probability distributions of gathered uncertain data were defined. Then analytical models were used to forecast the production. Two well evaluation results are presented in this paper. Based on the results, completion parameters affected the short-term and long-term production, while the reservoir parameters controlled the long-term production. Long-term well performance was mainly controlled by the fracture half-length and fracture height, whereas other completion and reservoir parameters have an insignificant effect. Stimulation treatment design defines the initial well performance, while well placement decision defines well long-term performance. The findings of this study would help in better understanding the production performance of shale gas reservoirs, maximizing production by selecting effective completion parameters and considering the governing reservoir parameters. Moreover, it would help in accomplishing more effective stimulation treatments and define the potentiality of the basin.
Geometric Simplification for Efficient Occlusion Culling in Urban Scenes (2001)

Most occlusion culling algorithms select a subset of suitable occluder planes or geometries to exclude invisible objects from further\nvisualization processing. Preferably these occluders are large and simple. For complex scenes it is worthwhile to generate virtual\noccluders to replace complex occluder geometries by simple polygonal structures. In urban scenes, the facade of buildings\ncomprises most of the occlusion potential. In this paper we present an algorithm to extract simplified facades from complex building\nmodels, exploiting the fact that, in most cases, buildings have a 2.5D structure.
Heat Transfer Characteristics of Fluidized Beds (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHeat Transfer Characteristics of Fluidized BedsHarold S. Mickley and Charles A. TrillingCite this: Ind. Eng. Chem. 1949, 41, 6, 1135–1147Publication Date (Print):June 1, 1949Publication History Published online1 May 2002Published inissue 1 June 1949https://pubs.acs.org/doi/10.1021/ie50474a007https://doi.org/10.1021/ie50474a007research-articleACS PublicationsRequest reuse permissionsArticle Views487Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Migratory nonparenchymal cells after organ allotransplantation: with particular reference to chimerism and the liver. (1994)

Evidence has been summarized that the migration from organ allografts of donor leukocytes of bone marrow origin and their ubiquitous persistence in recipient tissues is the previous unrecognized seminal explanation for allograft acceptance, and the first stage in the development of donor-specific nonreactivity (tolerance). The unusual immunologic privilege of the liver (called hepatic tolerogenicity) has been explained by its heavy content of leukocytes and its diverse lineage profile that includes precursor dendritic cells. In a direct extension of this new and generically applicable paradigm of transplantation immunology, unconditioned patients have been infused with donor bone marrow cells on the day of cadaveric liver, renal, and heart transplantation and treated otherwise with standard FK506-prednisone immunosuppression. All of the first 16 patients on this protocol have good whole organ function 2.5 to 13 months later. Using flow cytometry and qualitative or quantitative PCR techniques to detect donor HLA alleles, and with study of Y chromosomes in female recipients of male organs, persistent multilineage leukocyte chimerism was regularly found in the blood of these recipients. Rejection was diagnosed and successfully treated in 9 (56%) of these first 16 patients and transient GVHD in 2 (12.5%). Sustained donor-specific hyporeactivity as early as 40 days postoperatively was demonstrable with in vitro tests in the majority of these recipients.
A Ten-Year Plan for Formosa (1935)

Other| December 04 1935 A Ten-Year Plan for Formosa H. M. H. M. Search for other works by this author on: This Site PubMed Google Scholar Far Eastern Survey (1935) 4 (24): 195–196. https://doi.org/10.2307/3022550 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation H. M.; A Ten-Year Plan for Formosa. Far Eastern Survey 4 December 1935; 4 (24): 195–196. doi: https://doi.org/10.2307/3022550 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAsian Survey Search This content is only available via PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
Numerical simulation of a silicon-on-insulator waveguide Fabry-Perot interferometer for intensity light modulators at 1.3 μm (1997)

We present a new silicon-on-insulator (SOI) integrated optics structure to be used as an intensity light modulator at 1.3 /spl mu/m. The device consists of a waveguide Fabry-Perot interferometer. In association with a grating coupler this device could function as a spatial light modulator or a reflective-mode modulator. The Fabry-Perot reflectivity is tuned by free-carrier injection from a forward-biased lateral P/sup +//N/sup -//N/sup +/ diode. Consequently, the reflected back guided-mode has an intensity that is a function of the effective index modulation in the central waveguide of the Fabry-Perot. Our numerical simulation reveals that such a structure could function for current densities not exceeding 500 A/cm/sup 2/ with a cutoff frequency of 100 MHz. This new type of device is compatible with the mature silicon technology and could replace in applications the standard liquid-crystal spatial light modulators or for fiber-to-the-home intensity modulators.