gebhart/patrepeval huggingface dataset:
A tapered channel microfluidic device for comprehensive cell adhesion analysis, using measurements of detachment kinetics and shear stress-dependent motion (2012)

We have developed a method for studying cellular adhesion by using a custom-designed microfluidic device with parallel non-connected tapered channels. The design enables investigation of cellular responses to a large range of shear stress (ratio of 25) with a single input flow-rate. For each shear stress, a large number of cells are analyzed (500-1500 cells), providing statistically relevant data within a single experiment. Besides adhesion strength measurements, the microsystem presented in this paper enables in-depth analysis of cell detachment kinetics by real-time videomicroscopy. It offers the possibility to analyze adhesion-associated processes, such as migration or cell shape change, within the same experiment. To show the versatility of our device, we examined quantitatively cell adhesion by analyzing kinetics, adhesive strength and migration behaviour or cell shape modifications of the unicellular model cell organism Dictyostelium discoideum at 21 °C and of the human breast cancer cell line MDA-MB-231 at 37 °C. For both cell types, we found that the threshold stresses, which are necessary to detach the cells, follow lognormal distributions, and that the detachment process follows first order kinetics. In addition, for particular conditions' cells are found to exhibit similar adhesion threshold stresses, but very different detachment kinetics, revealing the importance of dynamics analysis to fully describe cell adhesion. With its rapid implementation and potential for parallel sample processing, such microsystem offers a highly controllable platform for exploring cell adhesion characteristics in a large set of environmental conditions and cell types, and could have wide applications across cell biology, tissue engineering, and cell screening.
Internal consistency and short-term test-retest reliability of the University of Pennsylvania Smell Identification Test (1985)

Measures of internal consistency and short-term test-retest reliability of the University of Pennsylvania Smell Identification Test (UPSIT) were determined in 69 people who showed a broad range of test scores at an earlier test administration. In addition, two procedures for releasing the microencapsulated odorants were compared. The split-half reliability coefficients for the two administrations were r = 0.930 and r = 0.957, respectively ( p <0.001). The test-retest (– 2-week interval) coefficient was r = 0.949 ( p <0.001). Release of the odorants by the tip of a #2 lead pencil resulted in scores equivalent to those obtained by releasing them with #120 sandpaper. These data, along with those collected previously on the long-term test-retest reliability ( r = 0.918), indicate that the UPSIT is a highly reliable and internally consistent test of smell function.
The Glove of Indolence (1971)

THERE dwelt in the land of Burigupp, beyond the known -*- latitudes, a Prince of Frogs. Mlagum he was called, the the Just One. Throughout the lands he cared for all; where there was no food, he fed; no shelter, he built. His name brought honor to every lip, and the Frogs were content...
SaaS Anonymous Cloud Service Consumption Structure (2012)

The contribution of this research focus on enhancing the privacy of cloud consumer enterprises while accessing cloud service providers in SaaS interactions. This is motivated by the fact that, during SaaS service consumption, providers have disproportionate access to consumers' information. Therefore, in the way of balancing the scenario, an anonymity technology approach is employed at the different layers of cloud service transactions. This results in a multi-layered privacy protection approach. Contracts, credentials and network-level communications are analyzed and treated with customized anonymity techniques. A complete framework is, then, proposed and a service consumption scheme is presented making use of group signatures as the mechanism for implementing anonymous credentials.
An algorithm for sampling descent graphs in large complex pedigrees efficiently (2003)

No exact method for determining genotypic and identity-by-descent probabilities is available for large complex pedigrees. Approximate methods for such pedigrees cannot be guaranteed to be unbiased. A new method is proposed that uses the Metropolis-Hastings algorithm to sample a Markov chain of descent graphs which fit the pedigree and known genotypes. Unknown genotypes are determined from each descent graph. Genotypic probabilities are estimated as their means. The algorithm is shown to be unbiased for small complex pedigrees and feasible and consistent for moderately large complex pedigrees.
Optical absorption in polymer glasses by laser calorimetry (1980)

Optical absorption in polystyrene and poly(methyl methacrylate) was measured in the visible region of radiation. Two methods of data evaluation yield consistent results to indicate that near λ=500 nm, the absorption coefficient is approximately 2×10−4 cm−1, or less than 100 dB/km, for both materials.
Abschlußbericht über die Durchführung des Maßnahmesystems im Rahmen der Intervallstudie "Junge Arbeiter" (1970)

Der vorliegende Bericht informiert über die Ermittlung und Überprüfung von ausgewählten Formen und Methoden der Leistungstätigkeit bei der Anwendung der sozialistischen Jugendpolitik im Bereich der Berufsausbildung in zwei volkseigenen Betrieben. Dazu wurde in vier Ausbildungsklassen von zwei Leipziger Betrieben ein Maßnahmeprogramm vorbereitet, eingesetzt und ausgewertet, das die Verbesserung der Einbeziehung der Lehrlinge des ersten Lehrjahres in die Planung und Leitung betrieblicher Aufgabenstellungen, die Festigung "klassenmäßiger Einstellungen und Verhaltensweisen" der Lehrlinge sowie die Erhöhung ihrer Betriebsverbundenheit vorsah. Gemessen wurden die Einstellung der Lehrlinge zur Arbeiterklasse und zur SED, die Einstellung zur Perspektive der sozialistischen Gesellschaftsordnung, zur DDR und zum Wehrdienst, politische Urteilsbildung und Aktivität, der Kontakt der Funktionäre und Leiter zu den Lehrlingen, die Einstellung der Lehrlinge zum Jugendverband, Einstellungen zum Beruf, zu wichtigen Bedingungen der Arbeit, das Verhältnis der Jugendlichen zum Lehrausbilder, die Beziehungen innerhalb des Arbeitskollektivs und Betriebsverbundenheit. (ICC)
HEAT TRANSFER IN MICROCHANNELS (2001)

Abstract In this article an attempt has been made to review the literature regarding heat transfer and pressure drop in one- and two-phase flow in microchannels. The emphasis has been on reports presented during the last few years. For single-phase flow, channels with hydraulic diameters less than 1 mm have been considered. For two-phase flow, very little information is available for such small channels. Also, for two-phase flow, deviations from largetube behavior start at diameters of a few millimeters. For these reasons a slightly larger diameter range has been considered in this case. As a conclusion, it can be stated that the understanding of flow in microchannels is increasing steadily, but that there are still many questions to be answered concerning the reasons for deviations from classical theory developed for larger channels.
Role of the Prostanoid EP4 Receptor in Iloprost-mediated Vasodilatation in Pulmonary Hypertension (2008)

Iloprost mediates vasodilatory functions via the EP4 receptor in the case of low IP receptor expression associated with pulmonary arterial hypertension. This is a previously unrecognized mechanism for iloprost, and illustrates that the EP4 receptor may be a novel therapeutic approach for the treatment of pulmonary arterial hypertension.
Optimization of Spray-Drying Process with Response Surface Methodology (RSM) for Preparing High Quality Graphene Oxide Slurry (2021)

The “Drying-redissolution” method is promising for the industrial production of high-concentration well-dispersed graphene oxide slurry (GOS). As the potential key step in this method, the spray drying process requires a statistical investigation which guides the large-scale preparation of graphene oxide powder (GOP). This work systematically studies the effects of operating parameters, including nozzle airflow rate (439–895 L·h−1), atomization pressure (0.5–0.7 MPa), and liquid feed rate (3.0–9.0 mL·min−1), by using the response surface methodology integrated Box–Behnken design (RSM–BBD), aiming to produce GOP with high yield and easy re-dispersion. The optimized spray drying condition is predicted to be 439 L·h−1, 0.59 MPa, and 9.0 mL·min−1, at which a powder yield of 70.45% can be achieved. The experimentally obtained GOP has an average particle size of 11.65 μm and the low crumpling degree of the particle morphology results in the good re-dispersibility (97.95%) and excellent adsorption performance (244.1 mg·g−1) of GOP. The GOS prepared by the spray-dried GOP possess low viscosity and high exfoliation efficiency with a single-layer fraction up to 90.8%, exhibiting good prospects for application. This work first applied the RSM–BBD model on the spray drying process of GO, and evidenced the possibility of producing high-quality GO slurry with the “drying-redissolution” method.
Sitka Magnetic Observatory, January to March 1938 (1938)

( Latitude 57° 03′.0 N., longitude 135° 20′.1 or 9 h 01 m . 3 W. of Gr .) January 4 —A small disturbance began gradually at about 10 h GMT and gradually increased in intensity to a maximum at 13 h 30 m . Thereafter the disturbance subsided; the trace had gradually returned to about normal values at 24 h January 24. Ranges: D , 74′; H , 799 gammas; Z , 608 gammas.
A low oversampling ratio 14-b 500-kHz ΔΣ ADC with a self-calibrated multibit DAC (1996)

Delta-sigma (/spl Delta//spl Sigma/) analog-to-digital converters (ADC's) rely on oversampling to achieve high-resolution. By applying multibit quantization to overcome stability limitations, a circuit topology with greatly reduced oversampling requirements is developed. A 14-bit 500-kHz /spl Delta//spl Sigma/ ADC is described that uses an oversampling ratio of only 16. A fourth-order embedded modulator, four-bit quantizer, and self-calibrated digital-to-analog converter (DAC) are used to achieve this performance. Although the high-order embedded architecture was previously thought to be unstable, it is shown that with proper design, a robust system can be obtained. Circuit design and implementation in a 1.2-/spl mu/m CMOS process are presented. Experimental results give a dynamic range of 84 dB with a sampling rate of 8 MHz and oversampling ratio of 16. This is the lowest oversampling ratio for this resolution and bandwidth achieved to date.
Development of a lipoprotein profile using capillary electrophoresis and mass spectrometry (1997)

A new program for lipoprotein characterization is outlined where capillary electrophoresis (CE) plays a central role in the analysis of intact lipoprotein serum components and the apoprotein domains. The first characterization step involves separation and particle density analysis of very low-, low-, and high-density lipoprotein fractions (VLDL, LDL, HDL) by ultracentrifugation and image analysis. VLDL, HDL, and LDL fractions are analyzed by capillary electrophoresis. Sodium dodecyl sulfate (SDS) at low concentrations in the background electrolyte used in the CE analysis is incorporated into the lipoprotein particle without appreciable delipidation, as determined by ultracentrifuge particle density analysis. Increasing the concentration of SDS results in extensive delipidation, resulting in the release of apoproteins (apo) which are detected as components of the electropherogram. Apo B-100 is detected in the delipidated VLDL and LDL fractions along with micelles of the lipids. Micelles from LDL delipidation have uniform charge densities. Apo A-I and A-II are detected in the HDL fraction. A new method for lipoprotein delipidation is introduced where the lipoprotein fraction is adsorbed on a reversed-phase hydrophobic cartridge. Delipidation and recovery of the apoprotein fractions is made by serial elutions with acetonitrile. CE of the lipid-free apoprotein mixture shows the presence of apoC-I,II,III and apoE in the VLDL fraction, and apoA-I,II apoC-I and apoE in the HDL fraction. Electrospray ionization mass spectrometry analysis gives the isoform distribution for each apoprotein. The identification of the apoproteins in the electropherograms is the first step in developing a CE-based quantitation method for measuring serum levels of these apoproteins and their distribution between the lipoprotein fractions. The assay described in this paper is being used as a level 2 and 3 cardiac risk profile analysis for individuals with normal lipid profiles who have a documented or family history of cardiovascular disease.
A Look Inside the San Andreas fault at Parkfield Through Vertical Seismic Profiling (2003)

The San Andreas Fault Observatory at Depth pilot hole is located on the southwestern side of the Parkfield San Andreas fault. This observatory includes a vertical seismic profiling (VSP) array. VSP seismograms from nearby microearthquakes contain signals between the P and S waves. These signals may be P and S waves scattered by the local geologic structure. The collected scattering points form planar surfaces that we interpret as the San Andreas fault and four other secondary faults. The scattering process includes conversions between P and S waves, the strengths of which suggest large contrasts in material properties, possibly indicating the presence of cracks or fluids.
Up-regulation of Cyclooxygenase-2 and Apoptosis Resistance by p38 MAPK in Hypericin-mediated Photodynamic Therapy of Human Cancer Cells (2003)

Photodynamic Therapy (PDT) is an approved anticancer therapy that kills cancer cells by the photochemical generation of reactive oxygen species following absorption of visible light by a photosensitizer, which selectively accumulates in tumors. We report that hypericin-mediated PDT of human cancer cells leads to up-regulation of the inducible cyclooxygenase-2 (COX-2) enzyme and the subsequent release of PGE2. Dissection of the signaling pathways involved revealed that the selective activation of p38 MAPK alpha and beta mediate COX-2 up-regulation at the protein and messenger levels. The p38 MAPK inhibitor, PD169316, abrogated COX-2 expression in PDT-treated cells, whereas overexpression of the drug-resistant PD169316-insensitive p38 MAPK alpha and beta isoforms restored COX-2 levels in the presence of the kinase inhibitor. Transcriptional regulation by nuclear factor-kappaB was not involved in COX-2 up-regulation by PDT. The half-life of the COX-2 messenger was drastically shortened by p38 MAPK inhibition in transcriptionally arrested cells, suggesting that p38 MAPK mainly acts by stabilizing the COX-2 transcript. Overexpression of WT-p38 MAPK increased cellular resistance to PDT-induced apoptosis, and inhibiting this pathway exacerbated cell death and prevented PGE2 secretion. Hence, the combination of PDT with pyridinyl imidazole inhibitors of p38 MAPK may improve the therapeutic efficacy of PDT by blocking COX-2 up-regulation, which contributes to tumor growth by the release of growth- and pro-angiogenic factors, as well as by sensitizing cancer cells to apoptosis.
Immunobiology of CR2, the B Lymphocyte Receptor for Epstein-Barr Virus and the C3d Complement Fragment (1988)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Mobile augmented reality interaction techniques for authoring situated media on-site (2006)

We present a set of mobile augmented reality interaction techniques for authoring situated media: multimedia and hypermedia that are embedded within the physical environment. Our techniques are designed for use with a tracked hand-held tablet display with an attached camera, and rely on "freezing" the frame for later editing.
Synthesis of tracer labelled [11,12‐<sup>3</sup>H]‐β‐carotene (2003)

Abstract The synthesis of tracer labelled [11,12‐ 3 H]‐β‐carotene is described. The procedure uses Wittig condensation of tracer labelled 3 H‐retinal (retinal spiked with [11,12‐ 3 H]‐retinal) with retinyl triphenylphosphonium bromide. The preparation of tracer labelled[ 3 H]‐β‐carotene is suitable for studies involving bioavailability and bioconversion of β‐carotene to vitamin A. Copyright © 2003 John Wiley & Sons, Ltd.
e-Learning and Social Networking Handbook: Resources for Higher Education (2008)

@contects:Table of Contents Chapter One: Social Networking as an Educational Tool Chapter Two: Design for a Distributed Environment Chapter Three: Selecting the Media Palette Chapter Four: The Tools in Practice Chapter Five: Constraints on Course Design Chapter Six: Evaluating Course Design and Understanding its Implications References Index
Cloning, Expression and Biological Activity of VEGI(151), a Novel Vascular Endothelial Cell Growth Inhibitor. (2000)

VEGI(vascular endothelial cell growth inhibitor) is a novel cytokine which belongs to the TNF super-family. In this study, the VEGI gene from ECV304 cells was cloned. A truncated form of VEGI, where 23 amino acids from N-terminal were deleted and named VEGI(151), was expressed in E.coli with 25.5% of expression rate. The purity of VEGI(151) reached 92.5% after purification. VEGI(151) showed significant inhibitory effect on endothelial cells. IC(50) of VEGI151 was 10 mg/L at 24 h. At the concentration of 0.613 mg/L, VEGI(151) induced apoptosis of endothelial cells within 36 h. However, neither stimulatory effect nor inhibitory effect of VEGI(151) was detected on tumor cells(A549 HepG2 Hela)cultured in vitro. These results suggest that endothelial cells was the main target cells of VEGI(151). Our findings indicate that VEGI(151) is a potential therapeutic drug on angiogenic disease and cancer.
Macrocycles, 8. Multiblock copoly(ether-esters) of poly(THF) andε-caprolactone via macrocyclic polymerization (1999)

It has been demonstrated that the “polycondensation” of poly(tetrahydrofuran)-diols with dibutlytin dimethoxide in bulk yields tin-containing poly(THF) macrocycles and not linear polycondensates. These macrocycles were characterized by 1H and 119Sn NMR spectroscopy, by elemental analyses, viscosity measurements and mass spectroscopy. Furthermore, the stoichiometric insertion of γ-thiobutyrolactones was studied. The tin-containing macrocyclic poly(THF)-2 000 was used as macrocyclic initiator for the polymerization of ε-caprolactone. The resulting macrocyclic block copoly(ether-esters) were reacted in situ with terephthaloyl chloride, succinyl chloride, or sebacoyl chloride. High temperatures proved to be advantageous for this polycondensation step. Number-average molecular weights (Mn's) up to 50 000 were obtained with polydispersity indices in the range of 1.6–1.7. The resulting tin-free multiblock copoly(ether-ester)s have the properties of thermoplastic elastomers and show good film-forming properties.
A novel experimental study on the fabrication and biological characteristics of canine bone marrow mesenchymal stem cells sheet using vitamin C (2015)

The aim of this study was to fabricate canine bone marrow mesenchymal stem cell sheet through the use of vitamin C, to identify the biological characteristics of the resulting cell sheets, and to reveal the potential mechanism of cell-sheet promotion by vitamin C. This study used vitamin C to induce bone marrow mesenchymal stem cells to proliferate. The resulting cells secreted large amounts of collagen, thereby shortening the construction time of the cell-sheet layer. In addition to these aims, we identified biological microcharacteristics of the cell sheet through histological observation, transmission electron microscopy, real-time PCR detection, immunohistochemical detection, and osteogenesis-induction experiments on the cell sheet. We were able to stably and rapidly construct bone marrow mesenchymal stem cell sheet, effectively harvest it, and transfer the seed cells for tissue engineering. This study indicates that the use of vitamin C for harvesting mesenchymal stem cell sheets from bone marrow may provide an easy and practical approach for bone tissue regeneration.
Measurement Of Thermospheric Temperatures And Winds By Remote Fabry-Perot Spectrometry (1980)

The measurement and analysis of thermospheric temperatures and winds with Fabry-Perot spectrometers are reviewed. It is shown how these measurements have been used to establish and define the dynamic behavior of the thermosphere.
Effects of a nonuniform current distribution on the kinetic inductance of a thin superconducting film (1974)

Kinetic inductance measurements were used to probe the current uniformity in thin amorphous Bi0.97 Tl0.03 films. Measurements were made on films having widths of 0.5 and 0.2 mm with thick thicknesses ranging from 300 to 2000 Å condensed on both quartz plates and Nb shield planes. The results for films without shield planes are compared to predictions based on approximate expressions for the current density in a thin film. The Nb shield plane appears to produce considerable smoothing of the current distribution. Measurements of the kinetic inductance of films on such a shield plane appear to provide a good method for the determination of the penetration depth in a-Bi.
Analysis and study of the influence of the geometrical parameters of mini unmanned quad-rotor helicopters to optimise energy saving (2017)

The article discusses lift force generated by mini UAVs (Unmanned Aerial Vehicles). CFD (Computational Fluid Dynamics) simulations were made on the base of a 3D scanned propeller model. Influence of some geometrical parameters of propeller (like velocity or pitch) and quadcopter (like gap) on lifting force was considered. Different propeller pitches were used and pitch influence on propeller lift force was analysed. Normally, lifting force will increase with the increasing of propeller pitch but for different rotation velocities, this increasing is different and in all cases, it can be approximated by a linear relationship. To obtain dependency functions, an equation for calculation of lift force given took into account the correction coefficients. This equation gave reliable results at pitch values equal to 0.3 -0.7 of the propeller diameter and at rotation velocities of 2000 min -1 -8000 min -1 .
Acid hydrolases and tryptase from secretory granules of dispersed human lung mast cells. (1981)

beta-Hexosaminidase, beta-glucuronidase, arylsulfatase, and tryptase were each released along with histamine from dispersed purified human lung mast cells of 40 to 80% purity by rabbit IgG anti-human IgE. The net per cent release ratio of each enzyme to histamine was determined over all doses of antibody employed to activate the mast cells and over all time points after activation, and indicated the per cent of each enzyme stored in secretory granules along with histamine. By multiplying the net per cent release ratio of each enzyme to histamine by total enzyme content in a preparation of 10(6) mast cells, values for secretory granule content per 10(6) mast cells were found to be 3.8 U for beta-hexosaminidase, 0.03 U for beta-glucuronidase, 0.03 U for arylsulfatase, and 0.9 U for tryptase. Subtype analysis of beta-hexosaminidase by diethylaminoethyl- (DEAE) cellulose chromatography revealed that the B isomer predominates in human mast cell secretory granules, whereas the A isomer predominates in secretory granules of the rat mast cell. Tryptase, the predominant neutral protease of the human mast cell secretory granule, has a m.w. of 130,000 by gel filtration chromatography, whereas the major neutral protease of the rat mast cell is chymotryptic and of 25,000 m.w. The presence of acid hydrolases, a tryptase, and histamine in human mast cell secretory granules suggests that the activated mast cell plays a direct role in the production of acute and subacute inflammation.