gebhart/patrepeval huggingface dataset:
Phosphorylation of RelA/p65 on Serine 536 Defines an IκBα-independent NF-κB Pathway (2005)

The association of the NF-kappaB p65/p50 dimer with IkappaBalpha plays a pivotal role in regulating its nuclear translocation and gene transcription. In addition, serine phosphorylation at various sites of the p65 subunit has been shown to be important in initiating transcription. Here we demonstrate that the regulation of nuclear translocation of p65 phosphorylated at serine 536 is not dependent on IkappaBalpha. Stimulation of either Jurkat or normal human T cells resulted in the nuclear translocation of phospho-p65 (Ser(536)). In addition, the phospho-p65 (Ser(536)) was not associated with either IkappaBalpha or p50, and the nuclear translocation of phospho-p65 (Ser(536)), but not total p65, was unaffected by the proteosome inhibitor MG-132, which blocks IkappaB protein degradation and prevents p65/p50 dimer nuclear translocation. Accordingly, the co-expression of a dominant negative mutant of IkappaBalpha blocked the transcriptional activity mediated by wild type but not the dominant positive p65 mutant (S536D). Furthermore, the transfection of the S536D form of p65 led to the induction of interleukin-8 transcription following stimulation, whereas the S536A form, which cannot be phosphorylated at this site, did not. Together, the findings suggest that p65 phosphorylated on serine 536 is not associated with or regulated by IkappaBalpha, that it has a distinct set of target genes, and that it may represent a noncanonical NF-kappaB pathway that is independent of IkappaBalpha regulation.
DKN: Deep Knowledge-Aware Network for News Recommendation (2018)

Online news recommender systems aim to address the information explosion of news and make personalized recommendation for users. In general, news language is highly condensed, full of knowledge entities and common sense. However, existing methods are unaware of such external knowledge and cannot fully discover latent knowledge-level connections among news. The recommended results for a user are consequently limited to simple patterns and cannot be extended reasonably. Moreover, news recommendation also faces the challenges of high time-sensitivity of news and dynamic diversity of users' interests. To solve the above problems, in this paper, we propose a deep knowledge-aware network (DKN) that incorporates knowledge graph representation into news recommendation. DKN is a content-based deep recommendation framework for click-through rate prediction. The key component of DKN is a multi-channel and word-entity-aligned knowledge-aware convolutional neural network (KCNN) that fuses semantic-level and knowledge-level representations of news. KCNN treats words and entities as multiple channels, and explicitly keeps their alignment relationship during convolution. In addition, to address users' diverse interests, we also design an attention module in DKN to dynamically aggregate a user's history with respect to current candidate news. Through extensive experiments on a real online news platform, we demonstrate that DKN achieves substantial gains over state-of-the-art deep recommendation models. We also validate the efficacy of the usage of knowledge in DKN.
X-ray diffraction study of laser deposited high Tc thin films on (001) SrTiO3 (1988)

We present a detailed x‐ray diffraction structural study of a YBa2Cu3O7−x superconducting film, deposited by a pulsed laser technique on (001) SrTiO3. The film was found to be polycrystalline with c‐axis preferential orientation normal to the substrate plane. We have also performed in‐plane diffraction experiments where we find that these grains are aligned along the substrate crystallographic axes in the plane in the film. From the x‐ray line widths, we observe residual strain broadening which we attribute to macroscopic compositional inhomogeneity.
Group communication in Amoeba and its applications (1993)

Unlike many other operating systems, Amoeba is a distributed operating system that provides group communication (i.e. one-to-many communication). The authors discuss design issues for group communication, Amoeba's group system calls, and the protocols to implement group communication. To demonstrate that group communication is a useful abstraction, they describe a design and implementation of a fault-tolerant directory service. They discuss two versions of the directory service: one with non-volatile RAM (NVRAM) and one without NVRAM. They give performance figures for both implementations.
The Reference Genome Sequence of<i>Saccharomyces cerevisiae</i>: Then and Now (2014)

The genome of the budding yeast Saccharomyces cerevisiae was the first completely sequenced from a eukaryote. It was released in 1996 as the work of a worldwide effort of hundreds of researchers. In the time since, the yeast genome has been intensively studied by geneticists, molecular biologists, and computational scientists all over the world. Maintenance and annotation of the genome sequence have long been provided by the Saccharomyces Genome Database, one of the original model organism databases. To deepen our understanding of the eukaryotic genome, the S. cerevisiae strain S288C reference genome sequence was updated recently in its first major update since 1996. The new version, called "S288C 2010," was determined from a single yeast colony using modern sequencing technologies and serves as the anchor for further innovations in yeast genomic science.
SCRIPTGARD: Preventing Script Injection Attacks in Legacy Web Applications with Automatic Sanitization (2010)

The primary defense against cross site scripting attacks in web applications is the use of sanitization, the practice of filtering untrusted inputs. We analyze sanitizer use in a shipping web application with over 400,00 lines of code, one of the largest applications studied to date. Our analysis reveals two novel problems: inconsistent sanitization and inconsistent multiple sanitization. We formally define these problems and propose SCRIPTGARD: a system for preventing such problems automatically matching the correct sanitizer with the correct browser context. While command injection techniques are the subject of intense prior research, none of the previous approaches consider both server and browser context, none of them achieve the same degree of precision, and many other mitigation techniques require major changes to server side code. Our approach, in contrast, can be incrementally retrofitted to legacy systems. We show how to provide an aid to testers during development. Finally we sketch how SCRIPTGARD can be used as a runtime mitigation technique. 1.
Notes (1931)

J. H. Quastel and Jas. Gibson, Analyst, 1931, 56, 311 DOI: 10.1039/AN9315600311
Functional Hepatocyte-Like Cells Derived from Human Bone Marrow Mesenchymal Stem Cells on a Novel 3-Dimensional Biocompatible Nanofibrous Scaffold (2008)

Overall data suggest that the engineered nanofibrous scaffold is a conductive matrix for functional hBMSC-derived hepatocyte-like cells and is promising for maintenance of hepatocytes suitable for implantation.
Therapeutic Trends (1964)

Journal Article Therapeutic Trends Get access William Johnson William Johnson Bronson Methodist Hospital, Kalamazoo, Michigan Search for other works by this author on: Oxford Academic Google Scholar American Journal of Hospital Pharmacy, Volume 21, Issue 3, 1 March 1964, Pages 129–130, https://doi.org/10.1093/ajhp/21.3.129 Published: 01 March 1964
Doxycycline in the treatment of falciparum malaria among aborigine children in West Malaysia (1981)

Doxycycline in a single dose was found to be a valuable drug in the treatment of chloroquine-resistant falciparum malaria. It was less effective in a single daily dose of 4 mg/kg body-weight for four days, when it cured only five out of nine patients, while a dosage of 4 mg/kg body-weight for seven days cured 23 out of 26 patients.
Controlled Thermocoagulation of Trigeminal Ganglion and Rootlets for Differential Destruction of Pain Fibers: Facial Pain other than Trigeminal Neuralgia (1976)

I describe the results of retrogasserian differential lidocaine block to aid in the selection of patients for a differential thermal lesion in the trigeminal ganglion and rootlets. This procedure temporarily duplicates the state of analgesia without anesthesia one seeks to make permanent with the radiofrequency heating. The results of this heating procedure are described in the treatment of 71 patients with facial pain of cancer, postherpetic, periodic migrainous neuralgia, acromegaly, trigeminal neuropathy, central pain, post-traumatic facial neuralgia, and atypical facial neuralgia.
Exploiting Heterogeneity in P2P Video Streaming (2010)

In this paper, we investigate the impact of peer bandwidth heterogeneity on the performance of a mesh-based P2P system for live streaming. We show that bandwidth heterogeneity constitutes an important resource for P2P live streaming systems. Indeed, by effectively exploiting it, the overall performance of the system is significantly improved. This requires the adoption of smart schemes for both the overlay topology construction and chunk scheduling mechanisms that discriminate among peers based on their bandwidth.
A monolithic visible, infrared and terahertz 2D detector (2010)

A monolithic multispectral detector for imaging in the visible (VIS), infrared (IR) and terahertz (THz) ranges has been designed for operation at room temperature. This sensor is composed of a CMOS readout integrated circuit (ROIC) housing visible photodiodes and of IR and THz microbolometer pixels processed above the CMOS wafer. Without package- and system-level issues, targeted individual pixel sensitivities are respectively an 80dB dynamic range for VIS photodiodes, a NETD=50mK @f/1 for IR and a THz NEP smaller than 10pW. Prototyping chips will be integrated in tri-spectral imaging and THz spectroscopy demonstration systems.
Das Gefüge der Realität (1990)

Es wird erzählt, daß ein Farmer ein Team von Wissenschaftlern damit beauftragt hatte, ihm eine Empfehlung zur Verbesserung seiner Milchproduktion auszuarbeiten. (Unterbrechen Sie mich, wenn Sie die Geschichte schon gehört haben.) Nach sechs Monaten Arbeit legten sie ihre Studie vor. Der Farmer fing an, sie zu lesen, und blieb gleich am ersten Satz hängen: «Betrachten Sie eine kugelförmige Kuh.»
<b>New Heteroaromatic Compounds. XVI.<sup>1</sup> Compounds with Heteroatoms at Bridgeheads</b><sup>2</sup> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Heteroaromatic Compounds. XVI.1 Compounds with Heteroatoms at Bridgeheads2Michael J. S. Dewar, Chikara. Kaneko, and M. K. BhattacharjeeCite this: J. Am. Chem. Soc. 1962, 84, 24, 4884–4887Publication Date (Print):December 1, 1962Publication History Published online1 May 2002Published inissue 1 December 1962https://pubs.acs.org/doi/10.1021/ja00883a050https://doi.org/10.1021/ja00883a050research-articleACS PublicationsRequest reuse permissionsArticle Views733Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
From structured documents to novel query facilities (1994)

Structured documents (e.g., SGML) can benefit a lot from database support and more specifically from object-oriented database (OODB) management systems. This paper describes a natural mapping from SGML documents into OODB's and a formal extension of two OODB query languages (one SQL-like and the other calculus) in order to deal with SGML document retrieval. Although motivated by structured documents, the extensions of query languages that we present are general and useful for a variety of other OODB applications. A key element is the introduction of paths as first class citizens. The new features allow to query data (and to some extent schema) without exact knowledge of the schema in a simple and homogeneous fashion.
Noninvasive Imaging of the Immune Checkpoint LAG-3 Using Nanobodies, from Development to Pre-Clinical Use (2019)

Immune checkpoint inhibition (ICI) is a promising cancer therapy, which has progressed rapidly from a preclinical concept to clinical implementation. Commonly considered targets in ICI are CTLA-4, PD-1/PD-L1, and LAG-3, and the list grows. As ICI is generally only beneficial for a subset of patients, there is a need to select patients that are eligible for therapy as well as to monitor therapy response. There is growing interest to do this noninvasively, by molecular imaging with target-specific tracers. To this day, noninvasive imaging has focused on CTLA-4 and PD-1/PD-L1, while there is no noninvasive tool available to accurately assess LAG-3 expression in vivo. In this proof-of-concept study, we developed nanobodies, the smallest functional fragments from camelid heavy chain-only antibodies, to noninvasively evaluate mouse LAG-3 expression using single photon emission computed tomography (SPECT)/CT imaging. The in vitro characterization of 114 nanobodies led to the selection of nine nanobodies binding to mouse LAG-3. The injection of <sup>99m</sup>Technetium-labeled nanobodies in healthy mice showed specific uptake in immune peripheral organs like the spleen and lymph nodes, which was not observed in LAG-3 gene knock-out mice. Moreover, nanobody uptake could be visualized using SPECT/CT and correlated to the presence of LAG-3 as assessed in flow cytometry and immunohistochemistry. SPECT/CT scans of tumor bearing mice further confirmed the diagnostic potential of the nanobodies. These findings substantiate the approach to use nanobodies as a tool to image inhibitory immune checkpoints in the tumor environment.
ChemInform Abstract: Efficient, Low Temperature Reformatsky Reactions of Extended Scope. (1986)

Abstract In Gegenwart von in situ aus Kaliumgraphit CgK, Zinkchlorid und Silberacetat erzeugtem Zink/Silber‐beschichtetem Graphit bilden Bromessigsäureethylester (II) und das cyclische Keton (I) in schneller Reaktion das Reformatskii‐Produkt (III).
Achievement of low-resistivity <i>p</i>-type ZnSe and the role of twinning (1989)

Past literature is replete with reports of well-conducting p-type ZnSe; however, such reports have either been poorly reproducible and/or have shown puzzling features which are incompatible with accepted semiconductor theory (e.g., p-type behavior via n-type dopants, better light emitting diodes from high-resistivity material, etc.). We have recently noted that ‘‘good’’ p-type material available to us has been heavily twinned, and moreover has shown ‘‘nonstandard’’ electrical behavior such as a negative differential resistivity. In the present paper the earlier literature is reanalyzed based on the concept that to date such p-type material has probably always been heavily twinned. A far improved understanding of the earlier work is obtained via the insight gained from these recent (twinning) results.
An outbreak of acute gastroenteritis associated with contaminated bottled water in a university – Jiangxi, China, 2012 (2012)

This gastroenteritis outbreak was most likely caused by contaminated bottled water. The company in question has been shut down and no further cases have been reported. Increased regulation of bottled water plants and better coordination between different investigators for future outbreaks is recommended.
Primary structure and developmental expression of <i>Bufo arenarum</i> cellular nucleic acid‐binding protein: Changes in subcellular localization during early embryogenesis (2001)

A Bufo arenarum cellular nucleic acid-binding protein (bCNBP) full-length cDNA was cloned. bCNBP is a 19.4 kDa protein containing seven CCHC zinc finger motifs, an RGG box and a Ser-rich region. Amino acid comparisons showed high values of homology in vertebrates and smaller values in insects or inferior eukaryotes. Northern blot analysis during oogenesis and early development revealed two transcripts with different expressions of pattern behavior. One of them is present in all stages analyzed, whereas the other is only detected from the beginning of zygotic transcription. Immunocytochemistry assays carried out on sections of ovary and early embryos showed that there was no specific staining of previtellogenic oocytes. In early vitellogenic oocytes, in oocytes at stages V/VI and in embryos at early blastula stage, reaction was observed inside the cytoplasm. At mid-blastula stage, CNBP was mainly detected in the epiblast. At the late gastrula stage, two layers of cells were stained in the archenteron roof, in which the internal one presented as strong staining. Nuclei in this layer were stained even stronger than the cytoplasm. Changes in mRNA expression patterns, accompanied by changes in subcellular localization, suggest that CNBP might interact with both nuclear and cytoplasmic nucleic acids.
The Preparation of β-Nitropropanoic Acid (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of β-Nitropropanoic AcidH. B. Hass, H. Feuer, and S. M. PierCite this: J. Am. Chem. Soc. 1951, 73, 4, 1858Publication Date (Print):April 1, 1951Publication History Published online1 May 2002Published inissue 1 April 1951https://pubs.acs.org/doi/10.1021/ja01148a521https://doi.org/10.1021/ja01148a521research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Histomorphometric assessment of the mechanisms for rapid ingrowth of bone to HA/TCP coated implants (1993)

The purpose of this work is to use dynamic histomorphometry to evaluate the basic biological mechanisms by which hydroxyapatite/tricalcium phosphate (HA/TCP) implant coatings accelerate bone formation rates. Twenty-five rabbits had an HA/TCP coated cylindrical titanium fiber metal mesh implant surgically placed in the subchondral bone of the proximal tibia and a noncoated implant placed in the contralateral tibia. Twenty-two of these animals had HA/TCP coated cylindrical solid titanium implants placed in the distal femur and an uncoated implant placed in the contralateral femur. The animals were double labeled with vital stains, and sacrificed at 3, 6, 16, or 26 weeks after surgery. Histomorphometric analyses were done of the bone implant interfaces. Both static and dynamic histomorphometric parameters indicate that HA/TCP coatings stimulate faster bone ingrowth to coated fiber metal implants through the early production of woven bone and by subsequent rapid lamellar bone formation rates. Coated fiber metal implants demonstrated significantly more bone ingrowth than noncoated implants through 16 weeks postimplantation, but not by 26 weeks. In solid implants, the differences between coated and noncoated implants are less pronounced and not statistically significant, although there is a trend toward increased bone apposition to the surface of the implants over the first 16 weeks following implantation. The clinical significance of these results is that coated implants may allow earlier return to normal weightbearing.
Development of a convenient spectrophotometric assay for peptide phosphorylation catalyzed by adenosine 3',5'-monophosphate dependent protein kinase (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDevelopment of a convenient spectrophotometric assay for peptide phosphorylation catalyzed by adenosine 3',5'-monophosphate dependent protein kinaseH. Neal Bramson, Nancy Thomas, William F. DeGrado, and E. T. KaiserCite this: J. Am. Chem. Soc. 1980, 102, 23, 7156–7157Publication Date (Print):November 5, 1980Publication History Published online1 May 2002Published inissue 5 November 1980https://pubs.acs.org/doi/10.1021/ja00543a068https://doi.org/10.1021/ja00543a068research-articleACS PublicationsRequest reuse permissionsArticle Views185Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Packaged thermo-optic polymer 1×2 switch (1995)

Thermo-optic components are advantageous for fiber management and bypass applications where high switching speeds are not required.1 We report on packaged and pigtailed single-mode polarization-independent thermo-optic 1×2 switches based on organic polymer waveguides. These switches are digital and require only that the drive signal exceed the switching threshold. Furthermore, the switches are solid state, have no moving parts, exhibit switching times an order of magnitude faster than mechanical switches, and can be operated with a high duty cycle.
Preparation and in vivo evaluation of two bovine hemoglobin‐based plasma expanders (1990)

A hemoglobin (Hb)-based oxygen carrier was successfully transfused into rats. An ultrapure lipid-free bovine Hb was prepared by hypotonic dialysis and ultrafiltration. The Hb was polymerized with glutaraldehyde and the P50 was 24.3 mm Hg. On the basis of immunological analysis, immuno-dot blot, the Hb preparations were not antigenic. A second transfusion produced no adverse immunological side effects. A right shift in P50 was obtained by further treatment of polymerized Hb with inositol hexaphosphate; however, this Hb preparation was unsuitable for transfusion as all animals died within a few minutes. A 30% exchange transfusion in rats with the polymerized bovine Hb resulted in a 100% survival of all animals. P50 values of treated animals were reduced by about 2 mm Hg for 14 days. The Hb product circulated for 14 days as determined by 51Cr labeling. Ultrapure bovine Hb has the potential to circulate and carry oxygen in rats and causes no immunological side effects.