gebhart/patrepeval huggingface dataset:
Identification of N-acetyl-d-glucosamine-specific lectins from rat liver cytosolic and nuclear compartments as heat-shock proteins (2001)

Cytosolic and nuclear O-linked N-acetylglucosaminylation has been proposed to be involved in the nuclear transport of cytosolic proteins. We have isolated nuclear and cytosolic N-acetyl-d-glucosamine (GlcNAc)-specific lectins from adult rat liver by affinity chromatography on immobilized GlcNAc and identified these lectins, by a proteomic approach, as belonging to the heat-shock protein (HSP)-70 family (one of them being heat-shock cognate 70 stress protein). Two-dimensional electrophoresis indicated that the HSP-70 fraction contained three equally abundant proteins with molecular masses of 70, 65 and 55kDa. The p70 and p65 proteins are phosphorylated and are themselves O-linked GlcNAc (O-GlcNAc)-modified. The HSP-70 associated into high molecular mass complexes that dissociated in the presence of reductive and chaotropic agents. The lectin(s) present in this complex was (were) able to recognize cytosolic and nuclear ligands, which have been isolated using wheat germ agglutinin affinity chromatography. These ligands are O-GlcNAc glycosylated as demonstrated by [3H]galactose incorporation and analysis of the products released by reductive β-elimination. The isolated lectins specifically recognized ligands present in both the cytosol and the nucleus of human resting lymphocytes. These results demonstrated the existence of endogenous GlcNAc-specific lectins, identified as HSP-70 proteins, which could act as a shuttle for the nucleo-cytoplasmic transport of O-GlcNAc glycoproteins between the cytosol and the nucleus.
Gβγ Isoforms Selectively Rescue Plasma Membrane Localization and Palmitoylation of Mutant Gαs and Gαq (2001)

Mutation of Galpha(q) or Galpha(s) N-terminal contact sites for Gbetagamma resulted in alpha subunits that failed to localize at the plasma membrane or undergo palmitoylation when expressed in HEK293 cells. We now show that overexpression of specific betagamma subunits can recover plasma membrane localization and palmitoylation of the betagamma-binding-deficient mutants of alpha(s) or alpha(q). Thus, the betagamma-binding-defective alpha is completely dependent on co-expression of exogenous betagamma for proper membrane localization. In this report, we examined the ability of beta(1-5) in combination with gamma(2) or gamma(3) to promote proper localization and palmitoylation of mutant alpha(s) or alpha(q). Immunofluorescence localization, cellular fractionation, and palmitate labeling revealed distinct subtype-specific differences in betagamma interactions with alpha subunits. These studies demonstrate that 1) alpha and betagamma reciprocally promote the plasma membrane targeting of the other subunit; 2) beta(5), when co-expressed with gamma(2) or gamma(3), fails to localize to the plasma membrane or promote plasma membrane localization of mutant alpha(s) or alpha(q); 3) beta(3) is deficient in promoting plasma membrane localization of mutant alpha(s) and alpha(q), whereas beta(4) is deficient in promoting plasma membrane localization of mutant alpha(q); 4) both palmitoylation and interactions with betagamma are required for plasma membrane localization of alpha.
A low-voltage low-power CMOS 5-GHz oscillator based on active inductors (2003)

A high-frequency, low-voltage, low-power tunable oscillator using active inductors as resonators is designed and simulated in TSMC 0.20-/spl mu/m CMOS technology. The oscillation frequency of the small and compact transistor-only circuit is 4.95 GHz with THD/spl ap/-80 dB. Phase noise is approximately -81 dBc/Hz at 500-kHz offset. For a 1.8-V supply voltage, the power consumption is less than 1.16 mW.
Die Synthese von <i>o</i>‐Acylamino‐β‐dimethylamino‐propiophenonen. 4. Mitt.: Synthese der primären Mannich‐Basen (1972)

Abstract Das durch Umsetzung von 2‐Acetamino‐β‐dimethylamino‐propiophenon (IVb) mit Dibenzylamin darstellbare 2‐Acetamino‐β‐dibenzylamino‐propiophenon (XXVII) kann hydrogenolytisch mit tels Palladium‐Aktivkohle in die entsprechende, nur am aromatischen Stickstoff acetylierte primäre Mannich‐Base übergeführt werden. In analoger Weise sind auch in 5‐Stellung substituierte Derivate des 2‐Acetamino‐β‐amino‐propiophenons (XXVIII) zugänglich.
Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells (2013)

Exosomal transfer of miR-214 is a paradigm for the regulation of CCN2-dependent fibrogenesis and identifies fibrotic pathways as targets of intercellular regulation by exosomal miRs.
Optical fibre transmission of multiplexed video signal using PWM (1989)

Optical-fibre technology is the key to the introduction of video and other related broadband services into any subcarrier network. This paper reports the design, construction and performance of a twin-channel multiplexed video transmission system using pulse width modulation (PWM) operating over 1 km of fibre suitable for use in such a network. The results indicate that overall the performance meets, and in many cases exceed, the spcifications laid down for transmission of broadast-quality TY signals. PWM is shown to be a vaiable low-cost alternative to the predominantly more complex and expensive digital systems requiring far greater bandwidth.
Active Learning With Gaussian Process Classifier for Hyperspectral Image Classification (2014)

Gaussian process (GP) classifiers represent a powerful and interesting theoretical framework for the Bayesian classification of hyperspectral images. However, the collection of labeled samples is time consuming and costly for hyperspectral data, and the training samples available are often not enough for an adequate learning of the GP classifier. Moreover, the computational cost of performing inference using GP classifiers scales cubically with the size of the training set. To address the limitations of GP classifiers for hyperspectral image classification, reducing the label cost and keeping the training set in a moderate size, this paper introduces an active learning (AL) strategy to collect the most informative training samples for manual labeling. First, we propose three new AL heuristics based on the probabilistic output of GP classifiers aimed at actively selecting the most uncertain and confusing candidate samples from the unlabeled data. Moreover, we develop an incremental model updating scheme to avoid the repeated training of the GP classifiers during the AL process. The proposed approaches are tested on the classification of two realworld hyperspectral data. Comparison with random sampling method reveals a better accuracy gain and faster convergence with the number of queries, and comparison with recent active learning approaches shows a competitive performance. Experimental results also verified the efficiency of the incremental model updating scheme.
A Stereoselective Entry to Tetrasubstituted Quinolizidines and the Puzzling Structural Assignment of the Lupin Alkaloid Plumerinine (2004)

A thermodynamically controlled stereoselective synthesis of quinolizidinone (+/-)-13 via α-amidoalkylation of an intermediate N-acyliminium ion derived from α-ethoxy piperidine 9, followed by intramolecular Michael addition is described. Based on their NMR data, quinolizidine alcohols 14 and 15 were ruled out as possible structures of the lupin alkaloid plumerinine.
State-space dimensionality in short-memory hidden-variable theories (2011)

Recently we have presented a hidden-variable model of measurements for a qubit where the hidden-variable state-space dimension is one-half the quantum-state manifold dimension. The absence of a short memory (Markov) dynamics is the price paid for this dimensional reduction. The conflict between having the Markov property and achieving the dimensional reduction was proved by Montina [A. Montina, Phys. Rev. A 77, 022104 (2008)] using an additional hypothesis of trajectory relaxation. Here we analyze in more detail this hypothesis introducing the concept of invertible process and report a proof that makes clearer the role played by the topology of the hidden-variable space. This is accomplished by requiring suitable properties of regularity of the conditional probability governing the dynamics. In the case of minimal dimension the set of continuous hidden variables is identified with an object living an $N$-dimensional Hilbert space whose dynamics is described by the Schr\"odinger equation. A method for generating the economical non-Markovian model for the qubit is also presented.
Systematic Review and Meta-Analysis of the Efficacy of Appropriate Empiric Antibiotic Therapy for Sepsis (2010)

Quantifying the benefit of early antibiotic treatment is crucial for decision making and can be assessed only in observational studies. We performed a systematic review of prospective studies reporting the effect of appropriate empirical antibiotic treatment on all-cause mortality among adult inpatients with sepsis. Two reviewers independently extracted data. Risk of bias was assessed using the Newcastle-Ottawa score. We calculated unadjusted odds ratios (ORs) with 95% confidence intervals for each study and extracted adjusted ORs, with variance, methods, and covariates being used for adjustment. ORs were pooled using random-effects meta-analysis. We examined the effects of methodological and clinical confounders on results through subgroup analysis or mixed-effect meta-regression. Seventy studies were included, of which 48 provided an adjusted OR for inappropriate empirical antibiotic treatment. Inappropriate empirical antibiotic treatment was associated with significantly higher mortality in the unadjusted and adjusted comparisons, with considerable heterogeneity occurring in both analyses (I(2) > 70%). Study design, time of mortality assessment, the reporting methods of the multivariable models, and the covariates used for adjustment were significantly associated with effect size. Septic shock was the only clinical variable significantly affecting results (it was associated with higher ORs). Studies adjusting for background conditions and sepsis severity reported a pooled adjusted OR of 1.60 (95% confidence interval = 1.37 to 1.86; 26 studies; number needed to treat to prevent one fatal outcome, 10 patients [95% confidence interval = 8 to 15]; I(2) = 46.3%) given 34% mortality with inappropriate empirical treatment. Appropriate empirical antibiotic treatment is associated with a significant reduction in all-cause mortality. However, the methods used in the observational studies significantly affect the effect size reported. Methods of observational studies assessing the effects of antibiotic treatment should be improved and standardized.
A Water Model Study on Molten Metal Flow in Die Cavity of Die Casting (1994)

Water modeling experiments and computer simulation for the predictions of defects of die castings are very important to produce high quality castings with less cost. The relation between the variable air vent system and the characteristics of the fluid flow in the die cavity is studied by using water modeling tests, which give ideas on reasonable designing of die cavity, vent arrangement and gating system. In order to test the water modeling, injection is done by using water containing NaCl. Flow behaviors in cavities are visualized by high speed camera and video tape recorder, and local filling time is measured with electrode sensors. Special attention is paid to the configuration of die cavity. Simulated results by computer are examined and compared with the results of water modeling experiments. There are close correlations between the simulated results and water modeling ones.
Exact computation of time and call blocking probabilities in multi-traffic circuit-switched networks (2002)

Studies a model of a network of links with the capacity of an integer number of bandwidth units that are shared amongst calls subdivided in K classes. A class is typified by the bandwidth requirement on each link and the average holding time of its calls. Calls arrive according to a Bernoulli-Poisson-Pascal process. The joint PDF of the number of bandwidth units in use, is found using a known recursion formula that is amenable to numerically instability. An algorithm that fixes the instability is proposed. Previous articles concentrated on time blocking probabilities. Those discussing call blocking probabilities suggest algorithms that are either approximative or time consuming. The present paper proposes a new one, that is shown to be superior in terms of accuracy and computation and storage overhead to the best exact algorithm available so far.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Crystallization from hydrochloric acid affords the solid-state structure of croconic acid (175 years after its discovery) and a novel hydrogen-bonded network (2001)

The structure of croconic acid is determined on single crystals grown from a solution of HCl 1 M; it is shown that O–H⋯O interactions organize the H2C5O5 molecules in an ‘accordion’ type supramolecular arrangement of hydrogen-bonded molecules; the stacking of [Cl]−·H2C5O5 units in the organometallic co-crystal [(η5-C5H5)2Co][Cl]·H2C5O5 is also analysed.
Improved single-round protocols for remote file synchronization (2005)

Given two versions of a file, a current version located on one machine and an outdated version known only to another machine, the remote file synchronization problem is how to update the outdated version over a network with a minimal amount of communication. In particular, when the versions are very similar, the total data transmitted should be significantly smaller than the file size. File synchronization problems arise in many application scenarios such as Web site mirroring, file system backup and replication, and Web access over slow links. An open source tool for this problem, called rsync and included in many Linux distributions, is widely used in such scenarios, rsync uses a single round of messages between the two machines. While recent research has shown that significant additional savings in bandwidth consumption are possible through the use of optimized multi-round protocols, there are many scenarios where multiple rounds are undesirable. In this paper, we study single-round protocols for file synchronization that offer significant improvements over rsync. Our main contribution is a new approach to file synchronization based on the use of erasure codes. Using this approach, we design a single-round protocol that is provably efficient with respect to common measures of file distance, and another optimized practical protocol that shows promising improvements over rsync on our data sets. In addition, we show how to obtain moderate improvements by engineering the rsync approach.
The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. (1994)

The expression of TS is an important independent prognosticator of disease-free survival and survival in patients with rectal cancer. Adjuvant fluorouracil (5-FU)-based chemotherapy demonstrated significant improvement in disease-free and overall survival for patients with high TS levels. Prospective studies measuring TS levels will be needed to understand further the role of TS as a prognosticator of survival and chemotherapeutic benefit.
Emerging Circulating Tumor Markers (2004)

Current tumor markers are limited in their clinical utilities. They are only useful for monitoring cancer patients during treatment and for detecting recurrence. Because of the lack of specificity and sensitivity, currently used tumor markers are not recommended for screening or diagnosis. Therefore, new tumor markers are being sought to improve the sensitivity for cancer detection and to improve the specificity for diagnosis. In this chapter we introduce several new tumor markers to complement currently used tumor markers. These new tumor markers may provide specificity and improved sensitivity for cancer management. Recently the importance of using tumor markers for target therapy, prognosis, and early detection has been emphasized (1). Therefore, there is a need to discover new circulating tumor markers for use in these areas. Introduced in this chapter are several new tumor markers that appear to have improved clinical utilities. In addition, a new group of circulating tumor markers are also described in this chapter relating to the signal transduction pathway, cell cycle, apoptosis, angiogenesis, and adhesion. This addition is largely owing to the recent change of emphasis on tumor markers. Instead of stressing diagnosis, monitoring and early detection of recurrence, the emphasis is placed at early tumor detection, prognosis, and target therapy. Note that these new tumor markers are also detectable in blood circulation. Because their appearance in the circulation are associated with various stages of growth regulation of cells, their detection could be correlated with prognosis and to be detectable in early neoplasm, and to be identifiable as target for target therapy. As will be shown below, these new markers involve not only oncoproteins and mutated suppressor proteins but also enzymes and various factors. Although not yet fully verified, these new tumor markers described here should greatly improve the use of circulating tumor markers in cancer management.
Identifying the Use of Data/Voice/Video-Based P2P Traffic by DNS-Query Behavior (2009)

There are more and more P2P applications in the Internet, with or without encrypted content. The P2P applications can be classified into three categories: file sharing (BT, eMule), VoIP (Skype, MSN), and video streaming (PPStream, PPLive). By observing the common communication nature among the peers, this paper proposes a simple but efficient way to identify the P2P traffic by the DNS query behavior. Experimental results illustrate that the proposed mechanism is able to accurately identify if a host is using data/voice/video-based P2P traffic, even the packet content is encrypted. The proposed mechanism is also capable of detecting future unknown P2P applications as long as they perform the common P2P behaviors.
The November Meeting of the Allegheny Mountain Section (1937)

"The November Meeting of the Allegheny Mountain Section." The American Mathematical Monthly, 44(5), pp. 278–279
OntoNav: a semantic indoor navigation system (2005)

In this paper we discuss issues related to the underlying information infrastructure needed in order to support location services and routing in indoor environments. Location based services are typically encountered in outdoor environments and rely on Geographical Information Systems (GIS) in order to correlate a wealth of data to the present location of a mobile terminal. We discuss the very interesting issue of routing within a building environment. Existing approaches are based exclusively on geometric information and neglect important aspects like semantics bound to building areas and user profiles. Hence, the derived applications do not reach the intelligence level anticipated by modern users. We extend the existing approaches through the introduction of user profiles and the adoption of an ontological framework for handling routing requests. We discuss all the algorithmic background used by the proposed system for resolving this interesting problem of mobile information services.
A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus (1997)

We developed a novel in vitro method for making nested deletions and applied it to a large-scale DNA sequencing. A DNA fragment to be sequenced (up to 15 kb long) was cloned with a new vector possessing two unique Sfi I sites, digested by Sfi I and ligated to generate a large head-to-tail concatemer. The large concatemer was randomly fragmented by sonication and then redigested by Sfi I to separate insert and vector DNAs. The fragments of various length were then cloned into the other vector(s) specifically designed for selective cloning of insert-derived DNA fragments to generate a library of nested deletions. This method allowed a single person to generate >20 nested deletion libraries sufficient to cover 100 kb in a few days. We applied the method for sequencing of P1 clones and successfully determined the complete sequence of approximately 300 kb of the human amyloid precursor protein (APP) locus on chromosome 21 with a redundancy of 3.8, reasonably low cost and very few gaps remaining to be closed. Development of some new instruments and software is also described which makes this method more applicable for large-scale sequencing.
Metal ion and metal chelate catalyzed oxidation of ascorbic acid by molecular oxygen. II. Cupric and ferric chelate catalyzed oxidation (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal ion and metal chelate catalyzed oxidation of ascorbic acid by molecular oxygen. II. Cupric and ferric chelate catalyzed oxidationM. M. Taqui. Khan and Arthur E. MartellCite this: J. Am. Chem. Soc. 1967, 89, 26, 7104–7111Publication Date (Print):December 1, 1967Publication History Published online1 May 2002Published inissue 1 December 1967https://pubs.acs.org/doi/10.1021/ja01002a046https://doi.org/10.1021/ja01002a046research-articleACS PublicationsRequest reuse permissionsArticle Views1060Altmetric-Citations134LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Improving comprehensiveness of information given to pediatric cardiac surgery patients prior to surgery]. (2012)

This intervention effectively increased the completion rate of preoperative instructions for pediatric patients scheduled for cardiac surgery and improved clinical pediatric nursing care practicability and efficiency.
Atomes à I’Intérieur d’un Interféromètre Perot-Fabry (1962)

In the optical masers realized so far a Perot-Fabry device is used as a multimode cavity. It may be interesting to investigate the general properties of such a device when the emitting or the absorbing atoms are put inside the reflecting mirrors. Even in the case when this device works below the threshold of maser action it shows remarkable properties which are worthwhile studying experimentally. The following aspects are considered in the paper: In the case of external illumination, the distribution of light intensity inside a Perot-Fabry interferometer is calculated. It is shown that the local light intensity in the stationary waves inside can be much higher than the intensity of the incident light beam. The properties of light emitted by atoms inside the Perot-Fabry and emerging from it are investigated. Narrow fringes of very strong intensity can be obtained. If the emitting atoms are located in an atomic beam the central fringe has natural line width, the Doppler broadening being suppressed. The realization of a fluorescent medium of lamellar structure is discussed. This structure favors one special mode of emission fringes. Finally, the absorption of atoms inside the interferometer is studied. It is shown that this device is equivalent to a long absorption path in an ordinary light beam.