gebhart/patrepeval huggingface dataset:
Palladium-catalysed enantiodivergent synthesis of cis- and trans-4-aminocyclohex-2-enols (1997)

Enantiomerically pure cis- and trans-4-aminocyclohex-2-enols are prepared from cyclohexa-1,3-diene via (-)-cis-(1R,4S )-4-acetoxycyclohex-2-enol (-)-2a using palladium(0) chemistry. Benzylamine and diethylamine are tested in the Pd0-catalysed allylic amination reactions. Since acetate is too slow as a leaving group and gave considerable amounts of side products, a number of leaving groups have been investigated. Of these phosphinate and 2,4-dichlorobenzoate are excellent leaving groups and result in efficient and highly stereoselective reactions; chloride as allylic leaving group also gives good results. By variation of the leaving group and proper choice of the protecting group it is possible to synthesise all four stereoisomers of 4-aminocyclohex-2-enol in good yield and high enantiomeric excess.
Expression and Functional Characterization of a pHis-Tagged Human Bradykinin B2 Receptor in COS-7Cells (2000)

A polyHis-tagged bradykinin (BK) B2 receptor (pHis-BKR) cDNA was constructed and expressed in COS-7 cells. The pHis-BKR is suitable for both immunoprecipitation and immunoblotting with anti-polyHis antibodies and can be easily purified using Ni-NTA columns. Immunochemical detection revealed a molecular mass of approximately 66 kDa. The pHis-BKR is capable of mediating BK-induced stimulation of inositol phosphate formation as well as of mitogen-activated protein kinase (MAPK) activity. Compared with the wild-type receptor (WT-BKR) the tagged receptor showed a slightly enhanced affinity towards BK but a reduced expression level. Despite these modified pharmacological properties the pHis-tagged BKR may be a useful tool for studying BKR modifications and signaling.
Sensitivity of elastic wave velocities to reservoir stress path (2005)

The change in pore pressure due to the production of hydrocarbons leads to changes in the stresses acting on the reservoir. Reservoir stress path is defined as the ratio of the change in effective horizontal stress to the change in effective vertical stress from the initial reservoir conditions, and strongly influences the depletion‐induced compaction behavior of the reservoir. The change in elastic wave velocities due to production is shown to be sensitive to reservoir stress path. This suggests that measurements of elastic wave velocities, amplitude versus offset, etc., may be used to monitor the reservoir stress path. Sensitivity of elastic wave velocities to reservoir stress path.
Predisposition for breast cancer in carriers of constitutional translocation 11q;22q. (1994)

A translocation between the long arms of chromosomes 11 and 22, t(11;22)(q23;q11), is the most frequent constitutional reciprocal translocation in man. This chromosome abnormality has not previously been reported to be associated with an increased risk for neoplasia. The observation of one patient with a constitutional translocation t(11q;22q) and breast cancer prompted us to study the relationship between these two conditions. The incidence of breast cancer was determined in carriers of t(11q;22q). The karyotypes were determined by QFQ-banding, and the breakpoints were then further characterized by fluorescent in situ hybridization. Eight families with a total of 22 balanced carriers were found. In five of these families there was one case of breast cancer each. In another family a case of an unknown malignancy was reported in one member. No other malignancies were found among these patients. The number of breast cancer cases was significantly higher than expected among the translocation carriers (P < .001). The chromosomal breakpoints showed the same localization with the markers used, in the seven families studied. The association of constitutional translocation t(11q;22q) and breast cancer identifies a subset of patients with a highly increased risk for breast cancer who would benefit from counseling and screening. It also suggests the involvement of genes on 11q and/or 22q, in the tumorigenesis of breast cancer.
TCR Trafficking in Resting and Stimulated T Cells (2004)

Dynamic regulation of TCR expression levels plays important roles in modulating T-cell responses during T-cell development and in mature T cells. TCR expression levels are determined by the rate constants for synthesis, endocytosis, recycling, and degradation. This review examines the rate constants, the molecular mechanisms, and the proposed physiological roles of TCR trafficking in resting and stimulated T cells. In resting T cells, the TCR slowly and constitutively cycles between the plasma membrane and the intracellular compartment. Constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif in the TCR subunit CD3g and might play a role in quality control of the TCR. TCR triggering induces an enhancement in the endocytic rate constant leading to TCR down-regulation. At least two pathways exist for endocytosis of triggered TCR. One is dependent on protein tyrosine kinase activity leading to ubiquitination of the TCR, whereas the other is dependent on protein kinase C (PKC)-mediated activation of the diL motif. In addition, nontriggered TCR are endocytosed (co-modulated) by the PKC/CD3g-dependent pathway. TCR down-regulation might attenuate signaling and/or might ensure an internal store of TCR that can be rerouted to the immunological synapse during the encounter with an antigen-presenting cell.
Poly-<i>p</i>-phenylene Phosphine/Polyaniline Alternating Copolymers:  Electronic Delocalization through Phosphorus (2005)

Phosphorus-containing poly(N-arylaniline)s and related polymer model compounds have been prepared. The spectroscopic and electronic properties of the materials were investigated via UV-vis-NIR spectroscopy and cyclic voltammetry. PPPP-PANI copolymers containing p-phenylene diamine units in the polymer backbone have electronic and spectroscopic properties characteristic of aromatic substituted p-phenylene diamines. Copolymers containing -(-C(6)H(4)-P-C(6)H(4)-P-C(6)H(4)-)- linkages between nitrogen centers show evidence for weak electronic delocalization along the polymer chain. The electrochemical and spectroscopic properties support strong electronic delocalization in copolymers containing -(-P-C(6)H(4)-N-C(6)H(4)-)- repeat units. The presence of a single diphenylphosphine bridge between nitrogen centers provides an efficient mode of electronic delocalization between nitrogen centers. PPPP oxide-PANI copolymers and related polymer model compounds were also prepared and investigated. The resemblance of PPPP oxide-PANI copolymers to isolated p-phenylene diamines or triarylamines suggests electronic isolation of the amine fragments in the polymer. The conversion of phosphorus(III) phosphines to phosphorus(V) phosphine oxides inhibits electronic delocalization through phosphorus, further supporting delocalization of the lone pair of electrons on phosphorus in PPPP-PANI copolymers. PPPP-PANI copolymers are a new type of pi-conjugated polymer with low oxidation potentials and electronic delocalization through phosphorus along the polymer chain.
A Comparison Of Leadership Styles And Gender Role Internalization Among Female Managers In The United States (2010)

The current research study examined the relationship between gender role internalization andtransformational and transactional leadership style in female managers. This researcher intended todiscover whether the internalization of messages that society presents about female behaviorcorrelates with the adoption of transformational leadership by women in management positions.Specifically, the researcher wanted to find out whether there was a higher level of gender roleinternalization among female transformational leaders than in female transactional leaders.
Multi-Hundred-Fiber Cable Composed of Optical Fiber Ribbons Inserted Tightly into Slots, (1986)

Abstract : A new type of cable assembly with a multitude of optical fibers is proposed and developed for use in subscriber loops. Optical fiber ribbons are tightly inserted into helically shaped rectangular slots on a polyethylene rod. Optical fiber ribbon and slot structures are investigated to minimize optical loss increase. Fiber coating and ribbon stranding structure design methods are presented. Fiber strains, especially a residual strain, are investigated. It is found that a residual strain is restricted to less than 0.05 % by selecting helical pitch of the slots as 700 mm or more to guarantee a required fiber life-time. Based on the design, 600-fiber cables are manufactured. It is demonstrated that the cables have excellent transmission properties through the mechanical and thermal tests and field trials. (Author)
9-V Algorithm for Test Pattern Generation of Combinational Digital Circuits (1978)

An algorithm for generating test patterns for combinational circuits has been developed and programmed. The algorithm is definitive and finds a test for all faults including those that require multiple paths to be sensitized, by sensitizing a single path at a time and trying at most each single path. This is achieved by using a new calculus based on nine values (0,1,D,D̄,0/D,0/D̄, 1/D,1/D̄,U). One path is deliberately sensitized while the alternative paths are assigned values which permit the option of desensitizing or sensitizing them as the sensitized path is developed. Experimental results are presented for a variety of cases.
Influence of plasma chemistry on impurity incorporation in AlN prepared by plasma enhanced atomic layer deposition (2013)

Impurities in aluminum nitride films prepared by plasma enhanced atomic layer deposition using NH3-, N2/H2- and N2-based plasmas are investigated by combining time-of-flight elastic recoil detection analysis (ERDA) and Fourier transform infrared spectroscopy. Different atomistic growth mechanisms are found to exist between the plasma chemistries. N2-plasma is shown as not suitable for the low-temperature deposition of AlN. Films deposited by NH3- and N2/H2-based processes are nitrogen rich and heavily hydrogenated. Carbon impurities exist at higher concentrations for the N2/H2-processes. The discovery of nitrile groups in the films indicates that carbon impurities can be partially attributed to an undesirable reaction occurring during the plasma step between nitrogen species and CH groups. Unremoved ligands from the metal precursor are the other source of carbon. A comparison of the hydrogen content within the films as determined by infrared absorption spectroscopy and ERDA suggests the NH3-based films have large quantities of unbonded hydrogen, whereas hydrogen in the N2/H2-based films is mostly in the form NHx. For the N2/H2-based processes, the addition of argon into the plasma mixture is shown to enhance amine formation.
Aflatoxin-induced tumors in mice (1974)

Mice were given a mixture of aflatoxins B and G subcutaneously ( 100 µg/day), by force feeding ( 100 µg/day) or by aerosol ( 1 mg/ml) for up to one year. Those given the aflatoxins subcutaneously developed local sarcomas in dose-related fashion. Those given aflatoxins by any route showed an incidence of lymphatic leukaemia significantly greater than age-matched control mice.
The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial (2013)

ClinicalTrials.gov NCT00711620.
Fully Automated Echocardiogram Interpretation in Clinical Practice (2018)

Our pipeline lays the groundwork for using automated interpretation to support serial patient tracking and scalable analysis of millions of echocardiograms archived within healthcare systems.
Two-year inhalation study of carcinogenicity and chronic toxicity of 1,4-dioxane in male rats (2009)

Carcinogenicity and chronic toxicity of 1,4-dioxane were examined by inhalation exposure of 50 male F344 rats to 1,4-dioxane vapor at 0 (clean air), 50, 250, or 1250 ppm (v/v) for 6 h/day, 5 days/wk, and 104 wk. Survival rates of 250 and 1250 ppm-exposed groups were decreased near the end of the 2-yr exposure period, due probably to the occurrence of malignant tumors. A statistically significant but marginal decrement of terminal body weight (<10%) was found in the 1250 ppm-exposed group, suggesting slight systemic toxicity. Significant changes in plasma levels of AST, ALT, ALP, and gamma-GTP and relative weight of the liver occurred in the 1250 ppm-exposed group. Dose-dependent and statistically significant increases in incidences of nasal squamous cell carcinomas, hepatocellular adenomas, and peritoneal mesotheliomas were found primarily in the 1250 ppm-exposed group. The incidences of renal cell carcinomas, fibroadenomas in the mammary gland, and adenomas in the Zymbal gland were also increased dose-dependently. Preneoplastic lesions occurred in the nasal cavity and liver of the 1,4-dioxane-exposed groups. As nonneoplastic lesions, the significantly increased incidences of nuclear enlargement, atrophy, and respiratory metaplasia in the nasal cavity were noted at 50 ppm and above. A LOAEL (lowest observed adverse effect level) was determined at 50 ppm for the nasal endpoint of general chronic toxicity. This study provides clear evidence of carcinogenicity for 1,4-dioxane in male rats. A cytotoxic-proliferative and in vivo genotoxic mode of action is suggested to operate in 1,4-dioxane-induced carcinogenesis.
Formal transfers of hydride from carbon-hydrogen bonds. Attempted generation of molecular hydrogen by intramolecular reduction of protons bound by 2,3-dihydro-1,3-dimethyl-2-(8-quinolinyl)-1H-benzimidazole (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormal transfers of hydride from carbon-hydrogen bonds. Attempted generation of molecular hydrogen by intramolecular reduction of protons bound by 2,3-dihydro-1,3-dimethyl-2-(8-quinolinyl)-1H-benzimidazoleBenoit Bachand, Socorro M. Ramos, and James D. WuestCite this: J. Org. Chem. 1987, 52, 24, 5443–5446Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November 1987https://pubs.acs.org/doi/10.1021/jo00233a026https://doi.org/10.1021/jo00233a026research-articleACS PublicationsRequest reuse permissionsArticle Views240Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Histone deacetylases: salesmen and customers in the post‐translational modification market (2009)

HDACs (histone deacetylases) are enzymes that remove the acetyl moiety from N-epsilon-acetylated lysine residues in histones and non-histone proteins. In recent years, it has turned out that HDACs themselves are also subject to post-translational modification. Such structural alterations can determine the stability, localization, activity and protein-protein interactions of HDACs. This subsequently affects the modification of their substrates and the co-ordination of cellular signalling networks. Intriguingly, physiologically relevant non-histone proteins are increasingly found to be deacetylated by HDACs, and aberrant deacetylase activity contributes to several severe human diseases. Targeting the catalytic activity of these enzymes and their post-translational modifications are therefore attractive targets for therapeutical intervention strategies. To achieve this ambitious goal, details on the molecular mechanisms regulating post-translational modifications of HDACs are required. This review summarizes aspects of the current knowledge on the biological role and enzymology of the phosphorylation, acetylation, ubiquitylation and sumoylation of HDACs.
Loopless Rop:  Structure and Dynamics of an Engineered Homotetrameric Variant of the Repressor of Primer Protein (2006)

The repressor of primer (Rop) protein has become a steady source of surprises concerning the relationship between the sequences and the structures of several of its mutants and variants. Here we add another piece to the puzzle of Rop by showing that an engineered deletion mutant of the protein (corresponding to a deletion of residues 30-34 of the wild-type protein and designed to restore the heptad periodicity at the turn region) results in a complete reorganization of the bundle which is converted from a homodimer to a homotetramer. In contrast (and as previously shown), a two-residue insertion, which also restores the heptad periodicity, is essentially identical with wild-type Rop. The new deletion mutant structure is a canonical, left-handed, all-antiparallel bundle with a completely different hydrophobic core and distinct surface properties. The structure agrees and qualitatively explains the results from functional, thermodynamic, and kinetic studies which indicated that this deletion mutant is a biologically inactive hyperstable homotetramer. Additional insight into the stability and dynamics of the mutant structure has been obtained from extensive molecular dynamics simulations in explicit water and with full treatment of electrostatics.
2001年:心理学领域的一部著作——评《二十世纪九十年代的心理学》 (1986)

由芬兰教授K.M.J.拉盖斯佩茨等人编著的《二十世纪九十年代的心理学》(1984,阿姆斯特丹)一书可以说是献给芬兰认识心理学家J.M.冯·赖特的60寿辰礼品.冯·赖特的国内外心理学同行和朋友们应约撰写论文,并对二十世纪九十年代的心理学发展趋势提出自己的看法.本书为心理学家们提供了思考和探讨今后10年心理学发展势趋的绝好机会.判断心理学的未来同确定研究范围和人员培训等方面的问题,都是密切有关的.大部分文章
The operation of a aluminium-air reserve power systems (2002)

Alupower-Chloride have developed a practical aluminium-air reserve battery which will provide over 150 Wh/dm/sup 3/ and 250 Wh/kg on discharge. The author describes both the principles and practicalities of operation of the reserve battery and techniques for incorporating them into power systems. The battery is intended to be used in conjunction with conventional, rechargeable, standby batteries and DC/DC power conversion equipment to provide cost-effective short- and long-term regulated power backup to key electrical installations. Two designs of the product are available capable of meeting electrical load requirements from 200 W to 2 kW for periods up to 72 h.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Power-Aware Run-Time System for High-Performance Computing (2005)

For decades, the high-performance computing (HPC) community has focused on performance, where performance is defined as speed. To achieve better performance per compute node, microprocessor vendors have not only doubled the number of transistors (and speed) every 18-24 months, but they have also doubled the power densities. Consequently, keeping a large-scale HPC system functioning properly requires continual cooling in a largemachine room, thus resulting in substantial operational costs. Furthermore, the increase in power densities has led (in part) to a decrease in system reliability, thus leading to lost productivity. To address these problems, we propose a power-aware algorithm that automatically and transparently adapts its voltage and frequency settings to achieve significant power reduction and energy savings with minimal impact on performance. Specifically, we leverage a commodity technology called "dynamic voltage and frequency scaling" to implement our power-aware algorithm in the run-time system of commodity HPC systems.
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of an Anti-Influenza B Virus Monoclonal Antibody, MHAB5553A, in Healthy Volunteers (2017)

ABSTRACT Influenza B can cause significant morbidity and mortality. MHAB5553A, a human monoclonal immunoglobulin G1 (IgG1) antibody that binds to a highly conserved region of the hemagglutinin protein of influenza B virus, is being examined as a novel therapeutic for the treatment of influenza B patients with severe disease. This phase 1, randomized, double-blind, placebo-controlled, single-ascending-dose study was conducted to assess the safety, tolerability, and pharmacokinetics (PK) of MHAB5553A. Twenty-six healthy male and female volunteers of >18 years of age were randomized into five cohorts receiving a single intravenous (i.v.) dose of 120, 1,200, 3,600, 8,400, or 10,800 mg MHAB5553A or placebo (four active:one placebo, except for the 120-mg cohort [4:2]). Subjects were followed for 120 days after dosing. No subject discontinued the study, no dose-limiting adverse events or serious adverse events were reported, and a maximum tolerated dose (MTD) was not defined. The most commonly reported adverse events were cold symptoms and headache; most were mild and occurred at a similar rate across all cohorts. MHAB5553A showed no relevant time- or dose-related changes in laboratory values or vital signs compared to the placebo. The observed serum PK was linear and generally dose proportional, and the observed nasal PK was nonlinear and generally non-dose proportional. MHAB5553A is generally well tolerated in healthy volunteers up to at least a single i.v. dose of 10,800 mg and demonstrated linear serum PK consistent with those of a human IgG1 antibody lacking known endogenous targets in humans. (This study has been registered at ClinicalTrials.gov under registration no. NCT02528903.)
RETRACTED ARTICLE: Inhibitors of apoptosis proteins in experimental benign prostatic hyperplasia: effects of serenoa repens, selenium and lycopene (2014)

The results indicate that IAPs may represent interesting targets for drug therapy of BPH.
Sno/scaRNAbase: a curated database for small nucleolar RNAs and cajal body-specific RNAs (2006)

Small nucleolar RNAs (snoRNAs) and Cajal body-specific RNAs (scaRNAs) are named for their subcellular localization within nucleoli and Cajal bodies (conserved subnuclear organelles present in the nucleoplasm), respectively. They have been found to play important roles in rRNA, tRNA, snRNAs, and even mRNA modification and processing. All snoRNAs fall in two categories, box C/D snoRNAs and box H/ACA snoRNAs, according to their distinct sequence and secondary structure features. Box C/D snoRNAs and box H/ACA snoRNAs mainly function in guiding 2'-O-ribose methylation and pseudouridilation, respectively. ScaRNAs possess both box C/D snoRNA and box H/ACA snoRNA sequence motif features, but guide snRNA modifications that are transcribed by RNA polymerase II. Here we present a Web-based sno/scaRNA database, called sno/scaRNAbase, to facilitate the sno/scaRNA research in terms of providing a more comprehensive knowledge base. Covering 1979 records derived from 85 organisms for the first time, sno/scaRNAbase is not only dedicated to filling gaps between existing organism-specific sno/scaRNA databases that are focused on different sno/scaRNA aspects, but also provides sno/scaRNA scientists with an opportunity to adopt a unified nomenclature for sno/scaRNAs. Derived from a systematic literature curation and annotation effort, the sno/scaRNAbase provides an easy-to-use gateway to important sno/scaRNA features such as sequence motifs, possible functions, homologues, secondary structures, genomics organization, sno/scaRNA gene's chromosome location, and more. Approximate searches, in addition to accurate and straightforward searches, make the database search more flexible. A BLAST search engine is implemented to enable blast of query sequences against all sno/scaRNAbase sequences. Thus our sno/scaRNAbase serves as a more uniform and friendly platform for sno/scaRNA research. The database is free available at http://gene.fudan.sh.cn/snoRNAbase.nsf.