gebhart/patrepeval huggingface dataset:
A Novel Hybrid Amplitude Modulated/Frequency Modulated Halftoning Based on Multilevel Halftoning (2006)

A digital gray scale image generally consists of 256 different gray tones. Printers and image setters normally generate much fewer levels and mostly only two levels. Therefore, in order to be able to display a digital cone-tone image by a multilevel device it has to be transformed into an image with fewer levels. The technique doing this transformation is called multi-level halftoning, and in the case of bilevel devices it is simply called halftoning. In this paper we propose a novel (bilevel) halftoning technique that is based on multilevel halftoning. The proposed method can also be categorized as belonging to hybrid amplitude modulated (AM)/ frequency modulated (FM) techniques. In this method the original digital image is firstly halftoned by a multilevel FM halftoning. Each level in the multilevel halftoned image is then replaced by a halftone table (microcell). An approach for extending any bilevel FM halftoning method to a multilevel method is also presented in this paper. The performance of the proposed method is examined by a number of illustrations where nonmodified error diffusion and our FM method are used. The problem with maze-like artifacts that occur when our FM halftoning, or similar methods such as DBS, are used as the macroscreen is discussed and a simple solution is introduced. An approach for extending the proposed method to be used in situations where the halftone dots cannot be produced smaller than a specific size is also proposed and examined. This modified version of the method can be useful for flexography, where the dots normally cannot be produced smaller than a critical size.
Proteomic identification of differentially expressed plasma membrane proteins in renal cell carcinoma by stable isotope labelling of a von Hippel‐Lindau transfectant cell line model (2009)

The von Hippel-Lindau (VHL) tumour suppressor gene plays a central role in development of clear cell renal cell carcinoma (RCC). Using a cell line pair generated from the VHL-defective RCC cell line UMRC2 by transfection with vector control or VHL (-/+VHL) and stable isotope labelling with amino acids in cell culture (SILAC) followed by enrichment of plasma membrane proteins by cell surface biotinylation/avidin-affinity chromatography and analysis by GeLC-MS/MS, VHL-associated changes in plasma membrane proteins were analysed. Comparative analysis of -/+VHL cells identified 19 differentially expressed proteins which were confirmed by reciprocal SILAC labelling. These included several proteins previously reported to be VHL targets, such as transferrin receptor 1 and the alpha 3 and beta1 integrin subunits and novel findings including upregulation of CD166 and CD147 in VHL-defective cells. Western blotting confirmed these changes and also revealed VHL-dependent alterations in protein form for CD147 and CD166, which in the case of CD166 was shown to be due to differential glycosylation. Analysis of patient-matched normal and malignant renal tissues confirmed these differences were also present in vivo in a subset of clear cell RCCs. These results illustrate the potential of this approach for identifying VHL-dependent proteins that may be important in tumorigenesis.
SHORT COMMUNICATION: Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers (1996)

Allelism in glutathione S-transferase GSTM1 and GSTT1 has been suggested as a risk factor in various cancers. Accordingly, we describe a group of case-control studies carried out to identify associations between GSTT1 genotypes and susceptibility to lung, oral, gastric and colorectal cancers. The frequencies of the putatively high risk GSTT1 null genotype were not increased in the lung, oral or gastric cancer cases compared with controls but the frequency of this genotype was significantly increased (P = 0.0011, odds ratio = 1.88) in the colorectal cancer cases. No significant interactions between the GSTT1 and GSTM1 null genotypes types were identified in the cancer groups studied. Indeed, no significant associations between GSTM1 genotypes and susceptibility were identified though further evidence was obtained that the protective effect of GSTM1*A and GSTM1*B is not equal. The data complement studies showing that GSTT1 null is associated with an increased susceptibility to total ulcerative colitis and suggests that this enzyme is important in the detoxification of unidentified xenobiotics in the large intestine.
Children With Congenital Intracardiac Defects (1977)

This 266-page atlas is divided into two parts. The first section provides an overall view of the changes in somatic growth, neurologic status, and psychological and psychiatric development of more than 300 children who underwent cardiac surgery between 1962 and 1967. In the second part of the book, data on 33 patients are presented in an atlas format, giving details of physical findings, laboratory procedures, and growth patterns, as well as neurological, psychological, and psychiatric observations. Anthropometric comparisons between boys and girls within broad categories of 1 to 9 and 9 to 10 years of age showed growth lag and delay of skeletal maturation in the preoperative patient. Although patients within the diagnostic subgroups of semilunar valve stenosis, left-to-right shunts, and right-to-left shunts were shown to have similar growth patterns, no attempt was made to correlate growth with the presence or degree of cyanosis or congestive heart failure or both.
American literature (1915)

American literature. By John Calvin Metcalf, Litt. D., professor of English, Richmond College. Atlanta, Richmond, and Dallas: B. F. Johnson Publishing Company and American literature. A study of the men and the books that in the earlier and later times reflect the American spirit. By William J. Long. Boston, New York, Chicago, and London Get access Journal of American History, Volume 2, Issue 1, June 1915, Pages 125–126, https://doi.org/10.2307/1889112 Published: 01 June 1915
Detection of the Stable Isotopes of Carbon Using a 3-Mv Van De Graaff and the Application to Environmental and Biological Studies (1974)

The proton radiative capture reactions, 12C(p, y)13N and 13C(p, y)14N, have been studied to determine their applicability for assaying materials for their 13C enrichment. This technique for determining carbon isotopic ratios compares favorably with the more classical analysis techniques for 13C tracer experiments.
Thermospray enhanced inductively coupled plasma atomic emission-spectroscopy detection for liquid chromatography (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermospray enhanced inductively coupled plasma atomic emission-spectroscopy detection for liquid chromatographyS. B. Roychowdhury and John A. KoropchakCite this: Anal. Chem. 1990, 62, 5, 484–489Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/ac00204a012https://doi.org/10.1021/ac00204a012research-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Molecular Score by Quantitative PCR as a New Prognostic Tool at Diagnosis for Chronic Lymphocytic Leukemia Patients (2010)

In our hands, this score is the most powerful tool for CLL risk stratification at the time of diagnosis.
C35 is overexpressed in colorectal cancer and is associated tumor invasion and metastasis (2015)

The aim of this study was to investigate the expression of C35, an oncogene previously found in breast and prostate cancers, and its clinicopathological significance in colorectal cancer (CRC). Qualitative and quantitative detection of C35 mRNA expression was performed using reverse transcription-PCR (RT-PCR) and real-time PCR. C35 protein expression was determined using immunohistochemistry. C35 mRNA was detected in none of 10 normal colorectal tissue samples, 55 of 65 (84.6%) CRC tissue samples, and 43 of 55 (78.2%) adjacent non-cancerous tissue samples. In addition, the level of C35 mRNA in CRC tissue samples was markedly higher than that in tumor adjacent non-cancerous tissue samples. C35 protein expression was detected in 58 of 80 (72.5%) CRC tissue samples and was closely associated with tumor serosal invasion, lymphnode metastasis, and an advanced Dukes stage. These results suggest that C35 might serve as a biomarker or therapeutic target for management of CRC.
Effects of sour cherry juice on blood glucose and some cardiovascular risk factors improvements in diabetic women (2008)

Purpose Some studies on anthocyanins have revealed their antioxidant activity and beneficial effects for diabetes control and reducing the risk of coronary heart diseases. It has been found that sour cherries contain high levels of anthocyanins that possess insulin‐releasing stimulatory properties on pancreatic β‐cells in vitro. The purpose of this paper is to investigate whether concentrated sour cherry juice (CSCJ) beneficially alters serum glucose and some cardiovascular risk factors in diabetes type 2 subjects. Design/methodology/approach In this quasi‐experimental study, 19 diabetic women with FBS ≥ 110 mg/dl were recruited from patients referred to the Diabetes Clinic of Shariati Hospital. Subjects were asked to consume 40 g of CSCJ daily for 6 weeks. Before the onset of the study (week 0) and after 6 weeks, weight and blood pressure measurements were done and fasting blood samples were drawn. FBS, hemoglobin A1c (HbA1c) and blood lipid profiles were measured. In addition, a 24‐hour food record was taken from all of the individuals in both stages. The Wilcoxon signed test was used for statistical analysis. Findings After six weeks' consumption of CSCJ, significant reductions in body weight ( p < 0.01), blood pressure and HbA1c ( p < 0.05) was seen. Total cholesterol and LDL‐C decreased significantly in a sub‐group of patients ( n = 12) with LDL‐C ≥ 100 mg/dl as well. Originality/value Based on the results of this study, consuming 40 g/day of CSCJ decreases body weight, blood pressure and HbA1c in diabetes type 2 women after 6 weeks and improves blood lipids in diabetic patients with hyperlipidemia.
Edge computing enabling the Internet of Things (2015)

Mobile Edge Computing (MEC), a new concept that emerged about a year ago, integrating the IT and the Telecom worlds will have a great impact on the openness of the Telecom market. Furthermore, the virtualization revolution that has enabled the Cloud computing success will benefit the Telecom domain, which in turn will be able to support the IaaS (Infrastructure as a Service). The main objective of MEC solution is the export of some Cloud capabilities to the user's proximity decreasing the latency, augmenting the available bandwidth and decreasing the load on the core network. On the other hand, the Internet of Things (IoT), the Internet of the future, has benefited from the proliferation in the mobile phones' usage. Many mobile applications have been developed to connect a world of things (wearables, home automation systems, sensors, RFID tags etc.) to the Internet. Even if it is not a complete solution for a scalable IoT architecture but the time sensitive IoT applications (e-healthcare, real time monitoring, etc.) will profit from the MEC architecture. Furthermore, IoT can extend this paradigm to other areas (e.g. Vehicular Ad-hoc NETworks) with the use of Software Defined Network (SDN) orchestration to cope with the challenges hindering the IoT real deployment, as we will illustrate in this paper.
Security and privacy for mobile healthcare networks: from a quality of protection perspective (2015)

With the flourishing of multi-functional wearable devices and the widespread use of smartphones, MHN becomes a promising paradigm of ubiquitous healthcare to continuously monitor our health conditions, remotely diagnose phenomena, and share health information in real time. However, MHNs raise critical security and privacy issues, since highly sensitive health information is collected, and users have diverse security and privacy requirements about such information. In this article, we investigate security and privacy protection in MHNs from the perspective of QoP, which offers users adjustable security protections at fine-grained levels. Specifically, we first introduce the architecture of MHN, and point out the security and privacy challenges from the perspective of QoP. We then present some countermeasures for security and privacy protection in MHNs, including privacy- preserving health data aggregation, secure health data processing, and misbehavior detection. Finally, we discuss some open problems and pose future research directions in MHNs.
Multi-Terminal VSC-HVDC System for Integration of Offshore Wind Farms and Green Electrification of Platforms in the North Sea (2008)

Abstract—This paper discusses a multi-terminal VSC-HVDC system proposed for integration of deep sea wind farms and offshore oil and gas platforms in to the Norwegian national grid onshore. An equivalent circuit of the VSC in synchronous d-q reference frame has been established and decoupled control of active and reactive power was developed. A three terminal VSC-HVDC was modeled and simulated in EMTDC/PSCAD software. Voltage margin method has been used for reliable operation of the HVDC system without the need of communication. Simulation results show that the proposed multi-terminal VSC-HVDC was able to maintain constant DC voltage operation during load switchings, step changes in power demand and was able to secure power to passive loads during loss of a DC voltage regulating VSC-HVDC terminal with out the use of communication between terminals.
Comparative Performance Analysis of Aided Carrier Tracking Loop Algorithms in High Noise/High Dynamic Environments (2004)

Five different approaches to GPS carrier tracking loops were compared in a simulated environment for their performance against a high dynamic/high noise environment. The loops tested were a second order loop, a third order loop, an aided second order loop, a Kalman filter, and an adaptive order loop. The simulation varied the jammer-to-signal (J/S) while holding inertial quality and acceleration profile constant. Similarly, the acceleration profile was varied with other factors constant. In a final test, the quality of inertial measurements was varied such as to resemble various qualities of available sensors and the other parameters held constant. Under high dynamics and high noise, the aided second order tracking loop provided the least amount of phase error. The adaptive order provides a good measured response under these configurations and does not requiring highly accurate accelerometer measurements.
Effect of nelfinavir on insulin metabolism, proteasome activity and protein degradation in HepG2 cells (2006)

HIV-1 protease inhibitors have revolutionized the treatment of HIV infection, but their use has been associated with lipodystrophy and insulin resistance. One suggestion for this has been the inhibition of insulin-degrading enzyme (IDE). We have previously demonstrated that insulin, through IDE, can inhibit the proteasome, thus decreasing cytosolic protein degradation. We examined whether the protease inhibitor nelfinavir inhibited IDE and its effect on protein degradation both in vitro and in whole cells. 125I-Insulin degradation was measured by trichloroacetic acid precipitation. Proteasome activities were measured using fluorogenic peptide substrates. Cellular protein degradation was measured by prelabelling cells with 3H-leucine and determining the release of TCA-soluble radioactivity. Nelfinavir inhibited IDE in a concentration-dependent manner with 50% inhibition at the maximal concentration tested, 100 microm. Similarly, the chymotrypsin-like and trypsin-like activities of the proteasome were decreased with an IC50 of approximately 3 microm. The ability of insulin to inhibit the proteasome was abrogated by nelfinavir. Treatment of HepG2 cells with 50 microm nelfinavir decreased 125I-insulin degradation and increased cell-associated radioactivity. Insulin alone maximally decreased protein degradation by 15%. Addition of 50 microm nelfinavir inhibited cellular protein degradation by 14% and blunted the effect of insulin. These data show that nelfinavir inhibits IDE, decreases insulin's ability to inhibit protein degradation via the proteasome and provides another possible mechanism for the insulin resistance seen in protease inhibitor-treated HIV patients.
A HIGHLY SELECTIVE INHIBITOR OF IκB KINASE, BMS-345541, AUGMENTS GRAFT SURVIVAL MEDIATED BY SUBOPTIMAL IMMUNOSUPPRESSION IN A MURINE MODEL OF CARDIAC GRAFT REJECTION (2004)

These results indicate that inhibition of IKK may serve as novel adjunctive therapy for the prevention of graft rejection.
Phase I trial of methotrexate-albumin in a weekly intravenous bolus regimen in cancer patients. Phase I Study Group of the Association for Medical Oncology of the German Cancer Society. (1999)

Methotrexate-albumin conjugate (MTX-HSA) is a novel human albumin-based prodrug conjugate of methotrexate (MTX). A low MTX loading rate provided optimal tumor targeting and therapeutic efficacy during preclinical testing. The objectives of this first Phase I study of MTX-HSA were to determine dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) in a weekly regimen. Seventeen cancer patients who were no longer amenable to standard treatment were enrolled and were evaluable for DLT. Up to eight injections were performed in weekly intervals. Dose escalation was as follows: 20, 40, 50, and then 60 mg/m2 MTX-HSA (based on the amount of MTX bound to albumin). Additional MTX-HSA courses were feasible in case of tumor response. DLT (mainly stomatitis, Common Toxicity Criteria grade 3) occurred, beginning at the 50 mg/m2 dose level after repeated administrations; in one case, thrombocytopenia was dose-limiting. Two events of DLT occurred at the 60 mg/m2 dose level within the first two administrations. Mild anemia, transaminitis, and one case of skin toxicity were found. No significant leukopenia, nausea, renal toxicity, or other toxicities were observed. MTX-HSA was well tolerated. Drug accumulation occurred on the weekly schedule. The half-life of the drug was estimated to be up to 3 weeks. Tumor responses were seen in three patients: (a) a partial response was seen in one patient with renal cell carcinoma (response duration, 30 months, ongoing); (b) a minor response was seen in one patient with pleural mesothelioma (response duration, 31 months, ongoing); and (c) a minor response was seen in one patient with renal cell carcinoma (response duration, 14 months until progression). Poststudy treatment was administered at 2-4-week intervals. No signs of toxicity or drug accumulation were seen. Altered pharmacological properties of MTX-HSA such as plasma half-life, tumor targeting, or intracellular metabolism might have contributed to these responses. The MTD for weekly administration was 4 x 50 mg/m2 MTX-HSA during short-term treatment. A regimen with MTX-HSA injections of 50 mg/m2 every 2 weeks was recommended for a further clinical Phase I study.
Fault diagnosis of nonlinear systems using higher order sliding mode technique (2009)

This paper presents a synthesis of fault diagnosis method for nonlinear systems through the parameter estimation using higher order sliding modes. Initially the uncertain parameters of nonlinear system using robust exact differentiator are estimated. Then residual signal is reconstructed using the estimated parameters, inputs, outputs and their estimated derivatives. The novelty of the method is the determination of unknown, uncertain system parameters by calculating accurate derivatives of the measured system inputs and outputs. To validate the technique, simulations have been performed for a uncertain nonlinear Three Tank System. The convergence in this approach is shown to be faster than similar existing techniques by an order of magnitude even in the presence of measurement noise. The proposed fault diagnosis technique requires no prior information about uncertain/unknown process parameters and statistical knowledge of process.
The Isolation of an Ion, a Precision Measurement of its Charge, and the Correction of Stokes's Law (1911)

In a preceding paper [2] a method for measuring the elementary electrical charge was presented which differed essentially which had been used by earlier observers only in that all of the measurements from which the charge was deduced were made upon one individual charged carrier. This modification eliminated the chief sources of uncertainty which inhered in preceding determinations by similar methods such as those made by Sir Joseph Thomson [3], H.A. Wilson [4], Ehrenhaft [5] and Broglie [6], all of whom had deduced the elementary charge from the average behavior in electrical and gravitational fields of swarms of charged particles.
MATHEMATICAL PROGRAMMING MODELS AND LOCAL SEARCH ALGORITHMS FOR THE OFFSHORE RIG SCHEDULING PROBLEM (2018)

This dissertation could not be possible without the support of several people
Arimetamycin A: Improving Clinically Relevant Families of Natural Products through Sequence‐Guided Screening of Soil Metagenomes (2013)

Sequence-tag-guided screening of soil environmental DNA libraries can be used to guide the discovery of new compounds with improved properties. In heterologous expression experiments the eDNA-derived arm cluster encodes arimetamycin A, an anthracycline that is more potent than clinically used natural anthracyclines and retains activity against multidrug-resistant (MDR) cancer cells.
[VII. Photodynamic therapy of Herpex simplex diseases]. (1977)

<p>Telecommunication networks make extensive use of power amplifiers (PAs) to broaden the coverage from transmitter to receiver. Achieving high power efficiency is challenging and comes at a price: the wanted linear performance is degraded due to nonlinear effects. To compensate for these nonlinear disturbances, existing techniques compute the preinverse of the PA by the estimation of a nonlinear model. However, the extraction of this nonlinear model is involved and requires advanced system identification techniques. The plant inversion iterative learning control (ILC) algorithm is used here in combination with the best linear approximation to investigate whether the nonlinear modeling step can be simplified. This paper introduces the ILC framework for the preinverse estimation and predistortion of PAs. The ILC algorithm is used to obtain a high quality predistorted input for the PA under study without requiring a nonlinear model of the PA. In a second step, a nonlinear preinverse model of the amplifier is obtained. Both the nonlinear and memory effects of a PA can be compensated by this approach. The convergence of the iterative approach and the predistortion results are illustrated on a simulation of a Motorola LDMOS transistor-based PA and a measurement example using the Chalmers RF WebLab measurement setup.</p>