gebhart/patrepeval huggingface dataset:
Schiff bases of pyridoxal phosphate with active center lysines of ribonuclease A (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSchiff bases of pyridoxal phosphate with active center lysines of ribonuclease AC. R. H. Raetz and D. S. AuldCite this: Biochemistry 1972, 11, 12, 2229–2236Publication Date (Print):June 6, 1972Publication History Published online1 May 2002Published inissue 6 June 1972https://doi.org/10.1021/bi00762a004RIGHTS & PERMISSIONSArticle Views152Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (956 KB) Get e-Alerts Get e-Alerts
Mobile computing application for industrial field service engineering: A case for ABB service engineers (2013)

The increasing digitalization of our daily lives is gaining a new momentum recently in what is called the post-desktop era of computing. This wide spread in digitalization is made possible by the introduction of handy devices specifically of mobile phones, laptop computers, Smartphones, and tablets. This new trend in shaping up technological advancement presents new opportunities for mobile information presentation, processing, and synthesis in different spheres of application such as providing industrial field services engineering support. Industrial field service engineers execute sets of work orders on daily basis plans. These work order executions demand the availability of digital information anywhere anytime to process them faster. This paper presents a scenario where the newly emerging Smartphone features such as augmented reality, audio / video processing, and near field communication sensing can be used to develop a prototype that supports industrial field service engineers in the contemporary field service engineering taskforces. It employs real world use-cases and carrying out quantitative prototype usability test analysis.
Synthesis and NMR of RNA with Selective isotopic enrichment in the bases (1995)

Efficient syntheses of pyrimidine and purine nucleosides and nucleotides with selective 13C enrichment in the base moieties are described. Uridine and cytidine are labeled at position C6 and adenosine and guanosine are labeled at position C8. The selectively labeled nucleosides were converted to nucleoside triphosphates and used with in vitro transcription to synthesize labeled RNA. Isotope-edited 12C and 13C sub-spectra of a omega 1-1/2-X-filtered NOESY experiment are demonstrated to be useful for making resonance assignments and for deriving structural information in large (> 20 nt) RNA molecules. The labeled RNAs also allow heteronuclear J-couplings and relaxation parameters to be measured without complications from 13C-13C J-couplings.
CHF Detection with LSTM Neural Network (2018)

Heart rate variability has been proven to be an effective prediction of risk of heart failure. The tradition method required manual feature extraction, thus may lead to potential error. In order to improve the robustness, a deep learning method based on long short-term memory has been presented in this paper. Three RR interval length (N) for detection are used. Without pre-processing, this method obtain 82.47%, 85.13% and 84.91% accuracy for N=50 (average time length is 37. 8s), N=100 (average time length is 73. 9s), N=500 (average time length is 369. 5s), respectively. This method makes it possible to detect CHF through intelligent hardware or mobile application.
Software-based GIC/GNSS compatible GPS receiver architecture using TMS320C30 DSP processor (1996)

The Global Navigation Satellite System (GNSS) refers to a world wide position and time determining system that uses satellite ranging signals to determine user position. It encompasses all satellite ranging technologies including GPS and additional satellites. The GNSS integrity channel (GIC) uses a network of ground stations at known locations to determine the status of every GNSS satellite in view of the network. Satellite health is then broadcast to GNSS users in real time via geostationary satellites. The paper describes the architecture of a software based GIC/GNSS compatible GPS receiver using the TMS320C30 DSP processor. The architecture is compatible with GPS, INM-3 GIC, the US WAAS GSO satellites and takes into account the future GNSS lightsats with GPS compatible architecture and carrier frequency offset from GPS L/sub 1/ frequency by approximately 1.023 MHz. The processor is used for correlation, filtering, decimation, demodulation, Viterbi decoding and navigation. The paper emphasises the Viterbi (k=7, r=1/2) decoder implementation in software for the WAAS and GIC satellites.
Fast conventional Fmoc solid‐phase peptide synthesis with HCTU (2007)

1H-Benzotriazolium 1-[bis(dimethyl-amino)methylene]-5-chloro-hexafluorophosphate (1-),3-oxide (HCTU) is a nontoxic, nonirritating and noncorrosive coupling reagent. Seven biologically active peptides (GHRP-6, (65-74)ACP, oxytocin, G-LHRH, C-peptide, hAmylin(1-37), and beta-amyloid(1-42)) were synthesized with reaction times reduced to deprotection times of 3 min or less and coupling times of 5 min or less using HCTU as the coupling reagent. Expensive coupling reagents or special techniques were not used. Total peptide synthesis times were dramatically reduced by as much as 42.5 h (1.8 days) without reducing the crude peptide purities. It was shown that HCTU can be used as an affordable, efficient coupling reagent for fast Fmoc solid-phase peptide synthesis.
A geometric parametrization for the virtual Euler characteristics of the moduli spaces of real and complex algebraic curves (2001)

We determine an expression $\xi ^s_g(\gamma )$ for the virtual Euler characteristics of the moduli spaces of $s$-pointed real $(\gamma =1/2$) and complex ($\gamma =1$) algebraic curves. In particular, for the space of real curves of genus $g$ with a fixed point free involution, we find that the Euler characteristic is $(-2)^{s-1}(1-2^{g-1})(g+s-2)!B_g/g!$ where $B_g$ is the $g$th Bernoulli number. This complements the result of Harer and Zagier that the Euler characteristic of the moduli space of complex algebraic curves is $(-1)^{s}(g+s-2)!B_{g+1}/(g+1)(g-1)!$ The proof uses Strebel differentials to triangulate the moduli spaces and some recent techniques for map enumeration to count cells. The approach involves a parameter $\gamma$ that permits specialization of the formula to the real and complex cases. This suggests that $\xi ^s_g(\gamma )$ itself may describe the Euler characteristics of some related moduli spaces, although we do not yet know what these spaces might be.
Context Tree Switching (2012)

This paper describes the Context Tree Switching technique, a modification of Context Tree Weighting for the prediction of binary, stationary, n-Markov sources. By modifying Context Tree Weighting's recursive weighting scheme, it is possible to mix over a strictly larger class of models without increasing the asymptotic time or space complexity of the original algorithm. We prove that this generalization preserves the desirable theoretical properties of Context Tree Weighting on stationary n-Markov sources, and show empirically that this new technique leads to consistent improvements over Context Tree Weighting as measured on the Calgary Corpus.
Efficient and Expressive Knowledge Base Completion Using Subgraph Feature Extraction (2015)

We explore some of the practicalities of using random walk inference methods, such as the Path Ranking Algorithm (PRA), for the task of knowledge base completion. We show that the random walk probabilities computed (at great expense) by PRA provide no discernible benefit to performance on this task, so they can safely be dropped. This allows us to define a simpler algorithm for generating feature matrices from graphs, which we call subgraph feature extraction (SFE). In addition to being conceptually simpler than PRA, SFE is much more efficient, reducing computation by an order of magnitude, and more expressive, allowing for much richer features than paths between two nodes in a graph. We show experimentally that this technique gives substantially better performance than PRA and its variants, improving mean average precision from .432 to .528 on a knowledge base completion task using the NELL KB.
The Use of Proteomics in Diagnostics: Liver Fibrosis Biomarkers (2016)

Proteomics can help to discover and quantify novel biomarkers and we show how this is achieved using liver fibrosis as an example. Liver biopsy is the reference standard for assessing liver fibrosis and serum biomarkers are less invasive. The severity of liver fibrosis can be determined using immunoassays. However biomarkers may be degraded due to sample storage conditions and therefore may not be detected using these antibody-based assays. Detection of biomarkers by mass spectrometry overcomes this disadvantage and the approach can be applied to all diseases. Two dimensional gel electrophoresis (2DE) was used to find differences in proteins in plasma samples from patients with varying liver fibrosis stages. The identified proteins were potential liver fibrosis biomarkers. Mass spectrometry can assay for biomarkers by detecting their tryptic peptides and fragments and was used to develop an antibody-free assay. We are the first and only lab in the UK to use a novel absolute quantitation method which is the only biomarker assay using a universal calibration mix. Using 2DE, we identified several potential biomarkers for liver fibrosis which were analysed by Western blotting using plasma samples from patients with varying stages of liver fibrosis. Our novel biomarkers were promising when compared to the markers used in current liver fibrosis tests. A mass spectrometry assay was developed for the best novel liver fibrosis biomarker. We are working towards the first ever antibody-free biomarker assay for liver fibrosis. Our assay is nine times faster than conventional quantitation by mass spectrometry making our approach for absolute biomarker quantitation applicable for clinical use. This is also the only assay which can analyse all points of the calibration curve and determine the absolute concentration of the biomarker in a single acquisition. Our assay may help reduce the need for invasive liver biopsies and the approach could be used for any other disease.
17-Allylamino-17-Demethoxygeldanamycin Synergistically Potentiates Tumor Necrosis Factor–Induced Lung Cancer Cell Death by Blocking the Nuclear Factor-κB Pathway (2006)

Nuclear factor-kappaB (NF-kappaB), a survival signal induced by tumor necrosis factor (TNF), contributes substantially to the resistance to TNF-induced cell death. Previous studies suggest that heat shock protein 90 (Hsp90) regulates the stability and function of receptor-interaction proteins (RIP) and IkappaB kinase beta (IKKbeta), the key components of the TNF-induced NF-kappaB activation pathway. In this study, we showed that the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17AAG) was synergistic with TNF to induce apoptotic cell death in a panel of lung tumor-derived cell lines. Treatment with 17AAG caused degradation of RIP and IKKbeta that, in turn, blocked TNF-induced NF-kappaB activation and antiapoptotic gene expression. The synergistic cytotoxicity was detected only when TNF treatment followed 17AAG preexposure. Importantly, the potentiation of cell death was abolished in NF-kappaB-disabled cells that express a nondegradable IkappaBalpha mutant (IkappaBalphaAA). These results suggest that the cytotoxicity seen with 17AAG and TNF treatment results from blocking TNF-induced NF-kappaB activation. The other components of the TNF receptor I signaling cascade were not altered, whereas TNF-induced c-Jun NH(2)-terminal kinase activation and apoptosis were potentiated. A similar synergism for inducing apoptosis was also observed in 17AAG-treated and TNF-related apoptosis-inducing ligand (TRAIL)-treated cancer cells. Our results suggest that NF-kappaB plays a key role in the resistance of lung cancer cells to TNF and TRAIL and that disabling this survival signal with 17AAG followed by TNF or TRAIL treatment could be an effective new therapeutic strategy for lung cancer.
Efficient and robust multicast routing in mobile ad hoc networks (2005)

We present the protocol for unified multicasting through announcements (PUMA) in ad-hoc networks, which establishes and maintains a shared mesh for each multicast group, without requiring a unicast routing protocol or the preassignment of cores to groups. PUMA achieves a high data delivery ratio with very limited control overhead, which is almost constant for a wide range of network conditions. Using simulations in Qualnet 3.5, we compare PUMA with ODMRP and MAODV, which are representatives of mesh-based and tree-based multicast routing in ad hoc networks. The results from a wide range of scenarios of varying mobility, group members, number of senders, traffic load, and number of multicast groups show that PUMA attains higher packet delivery ratios than ODMRP and MAODV, while incurring far less control overhead.
New space-time block codes for high throughput efficiency (2002)

Most current space-time block codes are designed based on an orthogonality principle. By relaxing the orthogonality requirement, it is possible to construct new codes with higher throughput efficiency. In this paper, new non-orthogonal space-time block codes for three transmit antennas are proposed, achieving throughput rates larger than those of currently known orthogonal designs. The proposed codes are found through a code search based on the rank criterion, determinant criterion and rank distribution. Performance results through Monte Carlo simulations demonstrate that there is a trade-off between the error-rate, diversity order and throughput rate.
Autologous bone marrow transplantation in acute leukemia with marrow purged with alkyl-lysophospholipid (1992)

Alkyl-lysophospholipids are anticancer agents that are selectively toxic to leukemic cells and relatively sparing of normal bone marrow cells. Thus, they would be likely candidates for purging remission marrows before autologous bone marrow transplant. One of the more promising agents is edelfosine, which could be safely used for purging without prolonging marrow recovery. Assays for marrow progenitor cells were performed before and after purging and cryopreservation in 64 patients. There was no significant reduction in colony formation after purging when compared with unpurged cryopreserved marrow, but there was a significant reduction after cryopreservation. Twenty-four patients with acute leukemia in second (16 patients) or third remission (3 patients), early relapse (3 patients), or in first remission with successfully treated extramedullary relapse (2 patients) received marrow-ablative chemotherapy and total body irradiation followed by infusion of marrow purged for 4 hours with 50 to 100 micrograms/mL of edelfosine. There were 9 lymphoblastic and 15 myelogenous leukemia patients. The median time to granulocyte recovery to 500/microL was 26 and 33 days for the 50 and 75 microgram/mL doses, respectively. The patient whose marrow was purged at the dose of 100 micrograms/mL failed to engraft. The median time to platelet recovery to 25,000/microL was 45 and 37 days for the 50 and 75 micrograms/mL doses, respectively. Twenty-nine percent of the patients remain disease free from 131 to 1,291 days, with a median of 356 days. These results have established that purging with 75 micrograms/mL of edelfosine is a safe dose and is recommended for a phase II trial.
Distributed threshold querying of general functions by a difference of monotonic representation (2010)

The goal of a threshold query is to detect all objects whose score exceeds a given threshold. This type of query is used in many settings, such as data mining, event triggering, and top- k selection. Often, threshold queries are performed over distributed data . Given database relations that are distributed over many nodes, an object's score is computed by aggregating the value of each attribute, applying a given scoring function over the aggregation, and thresholding the function's value. However, joining all the distributed relations to a central database might incur prohibitive overheads in bandwidth, CPU, and storage accesses. Efficient algorithms required to reduce these costs exist only for monotonic aggregation threshold queries and certain specific scoring functions. We present a novel approach for efficiently performing general distributed threshold queries. To the best of our knowledge, this is the first solution to the problem of performing such queries with general scoring functions. We first present a solution for monotonic functions, and then introduce a technique to solve for other functions by representing them as a difference of monotonic functions. Experiments with real-world data demonstrate the method's effectiveness in achieving low communication and access costs.
Inorganic engineered nanoparticles in drinking water treatment: a critical review (2015)

This review summarizes the recent research in the field of inorganic engineered nanoparticle development with direct or potential interest for drinking water treatment.
Online placement for dynamically reconfigurable devices (2005)

Reconfigurable hardware components such as FPGAs are used more and more in embedded systems, since such components offer a sufficient capacity for a complete SoC(System on a Chip) or even NoC(Network on a Chip). In order to use efficiently the dynamic and partial reconfiguration possibility on such components, one needs a support in the form of operating systems to manage both software and reconfigurable hardware. Online placement is one of these management issues that is investigated in this paper. Here we present a new approach for online placement of modules on reconfigurable devices. Also an optimisation of communication between running modules themselves and outside of the chip is proposed. The experimental results show a considerable decrease in communication and routing costs. Also task scheduling between hardware and software is investigated and a communication infrastructure for online placement has been proposed and implemented.
Cerebellum and Speech Perception: A Functional Magnetic Resonance Imaging Study (2002)

A variety of data indicate that the cerebellum participates in perceptual tasks requiring the precise representation of temporal information. Access to the word form of a lexical item requires, among other functions, the processing of durational parameters of verbal utterances. Therefore, cerebellar dysfunctions must be expected to impair word recognition. In order to specify the topography of the assumed cerebellar speech perception mechanism, a functional magnetic resonance imaging study was performed using the German lexical items "Boden" ([bodn], Engl. "floor") and "Boten" ([botn], "messengers") as test materials. The contrast in sound structure of these two lexical items can be signaled either by the length of the wordmedial pause (closure time, CLT; an exclusively temporal measure) or by the aspiration noise of wordmedial "d" or "t" (voice onset time, VOT; an intrasegmental cue). A previous study found bilateral cerebellar disorders to compromise word recognition based on CLT whereas the encoding of VOT remained unimpaired. In the present study, two series of "Boden - Boten" utterances were resynthesized, systematically varying either in CLT or VOT. Subjects had to identify both words "Boden" and "Boten" by analysis of either the durational parameter CLT or the VOT aspiration segment. In a subtraction design, CLT categorization as compared to VOT identification (CLT - VOT) yielded a significant hemodynamic response of the right cerebellar hemisphere (neocerebellum Crus I) and the frontal lobe (anterior to Broca's area). The reversed contrast ( VOT - CLT) resulted in a single activation cluster located at the level of the supratemporal plane of the dominant hemisphere. These findings provide first evidence for a distinct contribution of the right cerebellar hemisphere to speech perception in terms of encoding of durational parameters of verbal utterances. Verbal working memory tasks, lexical response selection, and auditory imagery of word strings have been reported to elicit activation clusters of a similar location. Conceivably, representation of the temporal structure of speech sound sequences represents the common denominator of cerebellar participation in cognitive tasks acting on a phonetic code.
Flexible high gain complementary inverter using n-ZnO and p-pentacene channels on polyethersulfone substrate (2008)

We report on the fabrication of complementary inverters that have ZnO and pentacene as n-type and p-type channels on a polyethersulfone substrate operating under 7V. Patterned Al and AlOx thin film were deposited at room temperature on the plastic as a common gate electrode and dielectric, respectively. After initial gate instability between ZnO channel and AlOx dielectric was controlled, our n-type thin-film transistors (TFTs) displayed quite a similar drain current level to that of p-type TFTs. Our flexible complementary device showed much high voltage gain of ∼100 even under a bent condition (56mm radius of curvature). Our complementary inverter also demonstrates a promising dynamic behavior of ∼20ms.
The histogenesis of cartilage and bone in the long bones of the embryonic fowl (1925)

Abstract The development and cytology of cartilage and bone in the limbs from the fifty‐second hour of incubation to the first day after hatching are described. The chief points of interest arising from this study are: (1) Chondroblasts when liberated during cartilage resorption die and disintegrate. (2) All the long bones possess structures which, though not undergoing independent ossification, are homologous with the mammalian epiphyses. (3) Endochondral ossification occurs only in the epiphyses and ends of the diaphyses. (4) The marrow cavity contains multinucleated giant cells which appear to be formed by the fusion of degenerating cells.
Improved design of CMOS multiple-input Muller-C-elements (1993)

The Muller-C-element is a basic building block for selftimed digital circuits. It is used to realise the AND function for events (signal transitions). This Letter presents an improved n-input Muller C-element design which provides tighter conditions for hazard-free operation with reduced hardware cost.
Synthesis and inhibitory activity of acetamidophosphonic acids against metallo-β-lactamases (2016)

GRAPHICAL ABSTRACT Synthesis and inhibitory activity of acetamidophosphonic acids against metallo-β-lactamasesAll authorsYi-Lin Zhang, Yue-Juan Zhang, Wen-Ming Wang & Ke-Wu Yanghttps://doi.org/10.1080/10426507.2016.1225741Published online:14 November 2016
Watching Night Come (1988)

Watching Night ComeOutside the fields nibble the strands of last light.Dusk clusters about fence posts, licking the pores of hard wood.In the pasture, horses wait for nightfall, for the ghost-flute of bones numbing.Night ambles through my kitchen, hanging its coat by the door, crawling under my bed sheets, slow, like a lazy woman who comes for nothing but sleep.