gebhart/patrepeval huggingface dataset:
Modeling and analysis of a wide speed range induction motor drive based on electronic pole changing (2002)

It has been previously demonstrated that an induction machine drive with contactorless pole changing can be achieved by reversing current directions of certain stator coil groups. This paper compares power and torque capability of this with conventional four pole and two pole induction machine drives. Based on the technique of vector space decomposition the machine coupled circuit model is transformed to a reference frame model. As a result of this transformation the coupled coil group variables can be replaced by equivalent decoupled four pole and two pole dq0 variables. This reference frame model facilitates the analysis and control of the machine drive especially during transients such as the pole changing transition.
Extinction of a Long A-C. Arc (1930)

The extinction of an a-c. arc is analyzed as depending on two factors, the rate of recovery of dielectric strength of the arc space after current zero, and the rate at which voltage tending to reignite the arc is applied by the external circuit. In the short arc, most of the recovered dielectric strength resides in a deionized layer next to the cathode but in the long arc the rest of the arc space contributes largely to the dielectric strength. The breakdown gradient of the still ionized arc space is defined, and using a thermal ionization theory, a formula for growth of breakdown gradient is derived. The extinction of long a-c. arcs in the open is greatly influenced by the sectional area which the arc stream has at current zero. By confining arcs to slots and holes, the rate of deionization at current zero is greatly increased, and so large voltages per cm. of arc can be interrupted. A gas blast passing turbulently through an arc stream greatly accelerates deionization at current zero and so is effective in increasing the capacity of the a-c. arc to interrupt high-voltage circuits. The expulsion fuse is an example of a gas blast circuit interrupter, the gas blast resulting from the decomposition of the fiber fuse case. The oil circuit breaker is also a gas blast circuit interrupter, the blast arising from the gases produced by the decomposition of the oil.
Cutting Edge: IL-6 Is a Marker of Inflammation with No Direct Role in Inflammasome-Mediated Mouse Models (2012)

IL-6 is a known downstream target of IL-1β and is consistently increased in serum from patients with NLRP3 inflammasome-mediated conditions. Therefore, IL-6 could be a therapeutic target in the treatment of IL-1β-provoked inflammation. IL-6 was increased in serum with accompanying neutrophilia in tissues of an inducible mouse model of Muckle-Wells syndrome. However, an IL-6-null background failed to provide phenotypic rescue and did not significantly impact inflammatory cytokine levels. In a second model of IL-1β-driven inflammation, NLRP3 activation by monosodium urate crystals similarly increased IL-6. Consistent with our Muckle-Wells syndrome model, ablation of IL-6 did not impact an acute neutrophilic response in this in vivo evaluation of gouty arthritis. Taken together, our results indicate that IL-6 is a reliable marker of inflammation, with no direct role in inflammasome-mediated disease.
Domain analysis for the reuse of software development experiences (1994)

We need to be able to learn from past experiences so we can improve our software processes and products. The Experience Factory is an organizational structure designed to support and encourage the effective reuse of software experiences. This structure consists of two organizations which separates project development concerns from organizational concerns of experience packaging and learning. The experience factory provides the processes and support for analyzing, packaging, and improving the organization's stored experience. The project organization is structured to reuse this stored experience in its development efforts. However, a number of questions arise: What past experiences are relevant? Can they all be used (reused) on our current project? How do we take advantage of what has been learned in other parts of the organization? How do we take advantage of experience in the world-at-large? Can someone else's best practices be used in our organization with confidence? This paper describes approaches to help answer these questions. We propose both quantitative and qualitative approaches for effectively reusing software development experiences.
OBT: Optical Burst Transport in Metro Area Networks (2007)

For the past few years, the evolution of electro-optical technology has driven change in optical networks in the access and backbone areas. Optical bypassing and traffic aggregation mitigate the scalability problem in backbone networks, and burst mode transmission can provide a cost-efficient solution for access networks. Using those technologies, a new solution can be found for metro area networks, which interconnect access and backbone networks. In this article, we introduce a new solution for metro area networks, called optical burst transport (OBT). OBT is designed to use the promising technologies of backbone and access networks so that it provides all benefits, such as dynamic bandwidth provisioning, scalability, and robustness for unbalanced traffic. The performance evaluation of OBT also is verified by means of a testbed implementation.
Novel laser intersatellite communication system employing optically preamplified PPM receivers (1995)

An original scheme for the utilisation of optically preamplified (EDFA) PPM receivers in intersatellite laser communications is presented. In order to facilitate high bit rate operation an analysis is presented for a PPM system employing threshold detection. When operating at the STM-1 bit rate of 155 Mbit/s and using conservative parameters the authors' model demonstrates a possible receiver sensitivity of 13.5 photons/bit (at a BER of 10-6) in the presence of background noise, thus indicating the impressive potential of the proposed receiver formation for use in satellite communications. The authors further demonstrate that their threshold detection PPM scheme can obtain receiver sensitivities up to 12.3 dB-better than an equivalent EDFA OOK NRZ satellite receiver, for which new results are also presented. Furthermore the results indicate that the PPM system may perform at sensitivities beyond the fundamental optically preamplified OOK NRZ limit of 27.3 photons/bit.
On the Emergence of an Application-Oriented Network Architecture (2007)

There is much debate today on what should be the architecture of the next generation of networks. In this paper, we address this question from the perspective of applications. We examine current and emerging applications to identify the factors that lead to a successful deployment. In addition to new computing models, we also examine trends in the mainstream information technology and telecom service provider industry, namely, Service Oriented Architecture and IP Multimedia Subsystem. We identify requirements of, and then present some views on what constitutes the future application-oriented networks architecture, and finally we propose a new model for future application-oriented networks and we discuss the research challenges.
Specificity, phenotype, and precursor frequency of primary cytolytic T lymphocytes specific for class II major histocompatibility antigens. (1985)

Most cytolytic T lymphocytes (CTL) recognize class I rather than class II MHC determinants, and relatively little is known about those CTL that do recognize class II MHC determinants. The present study was undertaken to document the specificity, phenotype, and precursor frequency of primary class II allospecific CTL. It was found that class II-allospecific CTL could be consistently generated in vitro from unprimed spleen or thymus populations in the presence of exogenously added helper factors. The class II MHC specificity of both the precursor and CTL effectors activated in primary cultures by Ia-disparate stimulator cells was documented both by blocking experiments with anti-Ia mAb and by the use of L cell transfectants. The mechanism by which primary allospecific CTL effectors lysed their targets appeared to involve direct cell-cell contact, because they failed to lyse bystander target cells. The frequency in unprimed spleen populations of precursor CTL specific for class II alloantigens was examined by limiting dilution analysis and was found to be as high as 1/15,000 splenocytes and approximately 10% of the frequency reported for primary class I allospecific CTL. Finally, the Lyt phenotype of primary class II allospecific CTL precursors and effectors was determined. It was found that anti-class II CTL derive from at least two distinct precursor subpopulations that are either L3T4+Lyt-2- or L3T4-Lyt-2+, and that the Lyt phenotype expressed by the CTL effectors are concordant with that of their precursors. No correlation was found between the I subregion gene products recognized by CTL effectors and the Lyt phenotype they expressed in that both I-A- and I-E-specific CTL were both L3T4+Lyt-2- and L3T4-Lyt-2+.
Dynamic Page Mapping Policies for Cache Conflict Resolution on Standard Hardware. (1994)

In computer systems with large, physically-indexed, direct-mapped caches, a poor mapping from virtual to physical pages causes excessive cache conflict misses. In a previous paper we proposed a simple hardware device, the Cache Miss Lookaside (CML) Buffer, which identifies pages that are suffering from conflict misses. The operating system can use this information to implement a dynamic page mapping policy that resolves conflicts by performing an in-memory copy of one of the conflicting pages, and updating the virtual to physical mappings. In this paper, we propose several dynamic page mapping policies that detect and resolve cache conflicts using hardware available in existing systems, such as a TLB and cache miss counter, to locate possible cache conflicts. We evaluate the simulated performance of a variety of mapping policies, and show that a dynamic page mapping policy using standard hardware can improve upon the performance of a static policy, but is not as effective as special-pu...
Stretchable Electrodes with High Conductivity and Photo‐Patternability (2007)

Electrically conductive materials that are elastomeric and photopatternable are presented. They are capable of achieving strains of up to 150% and thousands of cycles while retaining a low Young's modulus and low resistance. These compliant electrodes are made by mixing platinum salt into an elastomeric photo-polymer, exposing the film to UV light and developing, and then chemically reducing the Pt.
Physics-based RTD current-voltage equation (1996)

An analytic expression for the current-voltage characteristics of resonant tunneling diodes is derived from basic principles. The form is ideal for insertion into circuit simulation models. It is demonstrated for a conventional InGaAs-AlAs RTD and for an InAs-AlSb-GaSb RIT diode. The expression is based on the quantum tunneling formalism and contains parameters that originate from physical quantities, but which can also be treated as empirical. Empirical fitting is straightforward and results in an excellent match to the data. Additional levels of physical realism can be incorporated in a natural way.
Contribution of Ethylene Biosynthesis for Resistance to Blast Fungus Infection in Young Rice Plants (2006)

The role of ethylene (ET) in resistance to infection with blast fungus (Magnaporthe grisea) in rice (Oryza sativa) is poorly understood. To study it, we quantified ET levels after inoculation, using young rice plants at the four-leaf stage of rice cv Nipponbare (wild type) and its isogenic plant (IL7), which contains the Pi-i resistance gene to blast fungus race 003. Small necrotic lesions by hypersensitive reaction (HR) were formed at 42 to 72 h postinoculation (hpi) in resistant IL7 leaves, and whitish expanding lesions at 96 hpi in susceptible wild-type leaves. Notable was the enhanced ET emission at 48 hpi accompanied by increased 1-aminocyclopropane-1-carboxylic acid (ACC) levels and highly elevated ACC oxidase (ACO) activity in IL7 leaves, whereas only an enhanced ACC increase at 96 hpi in wild-type leaves. Among six ACC synthase (ACS) and seven ACO genes found in the rice genome, OsACS2 was transiently expressed at 48 hpi in IL7 and at 96 hpi in wild type, and OsACO7 was expressed at 48 hpi in IL7. Treatment with an inhibitor for ACS, aminooxyacetic acid, suppressed enhanced ET emission at 48 hpi in IL7, resulting in expanding lesions instead of HR lesions. Exogenously supplied ACC compromised the aminooxyacetic acid-induced breakdown of resistance in IL7, and treatment with 1-methylcyclopropene and silver thiosulfate, inhibitors of ET action, did not suppress resistance. These findings suggest the importance of ET biosynthesis and, consequently, the coproduct, cyanide, for HR-accompanied resistance to blast fungus in young rice plants and the contribution of induced OsACS2 and OsACO7 gene expression to it.
Inhibitory Activity on Amyloid-β Aggregation and Antioxidant Properties of<i>Crocus sativus</i>Stigmas Extract and Its Crocin Constituents (2006)

Crocus sativus stigmas are one of the widely known spices (saffron) and consist of unusually polar carotenoids. Alzheimer's disease is characterized pathologically by deposition of amyloid beta-peptide (Abeta) fibrils. Oxidation is thought to promote Abeta fibril formation and deposition. To identify agents inhibiting the pathogenesis of Alzheimer's disease, we examined in vitro the antioxidant properties of extract of C. sativus stigmas and its effect on Abeta(1-40) fibrillogenesis. The antioxidant properties were determined by measuring the ferric-reducing antioxidant power and Trolox-equivalent antioxidant capacity, while its effects on Abeta-aggregation and fibrillogenesis were studied by thioflavine T-based fluorescence assay and by DNA binding shift assay. The water:methanol (50:50, v/v) extract of C. sativus stigmas possesses good antioxidant properties, higher than those of tomatoes and carrots, and inhibited Abeta fibrillogenesis in a concentration and time-dependent manner. The main carotenoid constituent, trans-crocin-4, the digentibiosyl ester of crocetin, inhibited Abeta fibrillogenesis at lower concentrations than dimethylcrocetin, revealing that the action of the carotenoid is enhanced by the presence of the sugars. Our findings suggest the possible use of C. sativus stigma constituents for inhibition of aggregation and deposition of Abeta in the human brain.
Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption (2015)

Antiretroviral therapy (ART) suppresses HIV replication in most individuals but cannot eradicate latently infected cells established before ART was initiated. Thus, infection rebounds when treatment is interrupted by reactivation of virus production from this reservoir. Currently, one or a few latently infected resting memory CD4 T cells are thought be the principal source of recrudescent infection, but this estimate is based on peripheral blood rather than lymphoid tissues (LTs), the principal sites of virus production and persistence before initiating ART. We, therefore, examined lymph node (LN) and gut-associated lymphoid tissue (GALT) biopsies from fully suppressed subjects, interrupted therapy, monitored plasma viral load (pVL), and repeated biopsies on 12 individuals as soon as pVL became detectable. Isolated HIV RNA-positive (vRNA+) cells were detected by in situ hybridization in LTs obtained before interruption in several patients. After interruption, multiple foci of vRNA+ cells were detected in 6 of 12 individuals as soon as pVL was measureable and in some subjects, in more than one anatomic site. Minimal estimates of the number of rebounding/founder (R/F) variants were determined by single-gene amplification and sequencing of viral RNA or DNA from peripheral blood mononuclear cells and plasma obtained at or just before viral recrudescence. Sequence analysis revealed a large number of R/F viruses representing recrudescent viremia from multiple sources. Together, these findings are consistent with the origins of recrudescent infection by reactivation from many latently infected cells at multiple sites. The inferred large pool of cells and sites to rekindle recrudescent infection highlights the challenges in eradicating HIV.
Polycystic Ovary Syndrome (2006)

Polycystic ovary syndrome (PCOS), one of the most common causes of ovulatory infertility, affects 4-7% of women. Although it was considered that PCOS may have some genetic component and that clinical features of this disorder may change throughout a life span, starting from adolescence to postmenopausal age, no effort has been made to define differences in the phenotype and clinical presentation according to age. Indeed, it has been widely recognized in the last decade that several features of metabolic syndrome (MS), particularly insulin resistance and hyperinsulinemia, are inconsistently present in the majority of women with PCOS. This represents an important factor in the evaluation of PCOS throughout life, which implies that PCOS by itself may not be a hyperandrogenic disorder exclusively related to young and fertile-aged women, but may also have some health implications later in life. In young women with PCOS, hyperandrogenism, menses irregularities, and insulin resistance may occur together, emphasizing the pathophysiological role of excess androgen and insulin on PCOS. Hyperandrogenism and infertility represent the major complaints of PCOS in adult fertile age. In addition, obesity and MS may affect more than half these women. Later in life, it becomes clear that the association of obesity (particularly the abdominal phenotype) and PCOS renders affected women more susceptible to develop type 2 diabetes mellitus (T2DM), with some difference in the prevalence rates among countries, suggesting that environmental factors are important in determining individual susceptibility. Little is known about ovarian morphology and androgen production in women with PCOS after menopause. Some studies found that morphological ultrasonographic features consistent with polycystic ovaries are very common in postmenopausal women, and that these features are associated with higher than normal testosterone levels and metabolic alterations. There is an obvious need for further research in this area. Identification of major complaints and features of PCOS during the different ages of an affected woman may help, in fact, to plan individual therapeutic strategies, and, possibly, prevent long-term chronic metabolic diseases.
FOXO1 is a tumor suppressor in classical Hodgkin lymphoma (2012)

The FOXO transcription factors control proliferation and apoptosis in different cell types. Their activity is regulated by posttranslational modifications, mainly by the PI3K-PKB pathway, which controls nuclear export and degradation. We show that FOXO1 is highly expressed in normal germinal center B cells as well as in non-Hodgkin lymphomas, including follicular lymphoma, diffuse large B-cell lymphoma, mucosa-associated lymphoid tissue non-Hodgkin lymphoma, B-cell chronic lymphocytic leukemia, and mantle cell lymphoma. In contrast, in 31 of 32 classical Hodgkin lymphoma (cHL) cases, Hodgkin and Reed-Sternberg cells were FOXO1 negative. Neoplastic cells of nodular lymphocyte-predominant Hodgkin lymphoma were negative in 14 of 20 cases. FOXO1 was down-regulated in cHL cell lines, whereas it was expressed in non-Hodgkin lymphoma cell lines at levels comparable with normal B cells. Ectopic expression of a constitutively active FOXO1 induced apoptosis in cHL cell lines and blocked proliferation, accompanied with cell-cycle arrest in the G(0)/G(1) phase. We found that, in cHL cell lines, FOXO1 is inactivated by multiple mechanisms, including constitutive activation of AKT/PKB and MAPK/ERK kinases and up-regulation of microRNAs miR-96, miR-182, and miR-183. These results suggest that FOXO1 repression contributes to cHL lymphomagenesis.
Reducing acquisition costs with random sampling and multidimensional interpolation (2011)

By combining random sampling in 3D survey design with multidimensional interpolation in processing, we can reduce acquisition costs without unduly sacrificing spatial resolution. We demonstrate this on a densely acquired data set.
Growth Mechanism of Indium Tin Oxide Whiskers Prepared by Sputtering (2007)

Whisker structures of indium tin oxide were prepared on a glass substrate by conventional sputtering using an indium-tin alloy target. Whisker structures grew well at higher temperatures than the crystallization temperature of In2O3 and the melting temperature of the In–Sn alloy, and also under the sputtering conditions of comparatively scarce oxygen and a high sputtering rate. These sputtering conditions correspond to the transition mode of reactive sputtering. The whisker structures were categorized into a structure consisting of many needles and a structure consisting of many trunks with side branches. Each whisker was a bcc single crystal growing along the <222> direction and had a spherical droplet-like structure on the tip. Consequently, it was revealed that In–Sn droplets acted as important cores of whisker growth. The indium tin oxide (ITO) whiskers were grown by a self-catalytic vapor–liquid–solid mechanism promoted by the supersaturation of indium vapor.
Preparation and properties of sol-gel derived PZT thin films for decoupling capacitor applications (1994)

Abstract The use of ceramic thin films as decoupling capacitors offers the possibility of capacitor integration within the integrated circuit (IC) package, and potentially, directly onto the IC itself. Since these configurations minimize series inductance, higher operational speeds are possible. In the present study we have investigated the dielectric and leakage characteristics of sol-gel PZT films. For compositions near the morphotropic phase boundary, dielectric constants of 1000, and loss tangents of about 0.02, were observed. The current-voltage behavior of the capacitors was characterized by a non-linear response, and significant asymmetry in both the leakage and breakdown characteristics as a function of bias sign was observed. Breakdown fields for PZT 53/47 thin films were typically ∼800 kV/cm at 25°C. We have also studied the effects of La and Nb dopant additions and alternate firing strategies on film leakage characteristics. Donor doping at 2–5 mol% lowered leakage currents by a factor of 103 For films prepared by a multilayering approach, firing each layer to crystallization resulted in leakage currents that were a factor of 102 lower than films prepared by the standard process.