gebhart/patrepeval huggingface dataset:
El aprendizaje relevante en la formación didáctica de los futuros maestros (1997)

Promover el aprendizaje relevante en la formacion inicial de los profesores es una de las aspiraciones mas extendidas entre los responsables de dicha formacion. En esta linea, la comunicacion presenta un proyecto que tiene como objeto identificar las creencias que los futuros profesores tienen acerca de la ensenanza para provocar la reconstruccion de su conocimiento.
Self-Assembly for Semiconductor Industry (2007)

Fabrication technologies for the semiconductor industry have enabled ever-smaller devices but now face fundamental limits in creating nanoscale products. Self-assembly has recently emerged as a promising alternative fabrication technology for functional nanoscale systems. Such processes can be made parallel and are capable of producing three-dimensional structures with ~10 nm precision. This paper reviews developments, applications and challenges of self-assembly methods for the semiconductor industry. Although a fully self-assembled nanoscale system has not yet been commercially achieved, the work reviewed and discussed here demonstrates a solid scientific foundation in pursuing this goal.
The <i>in vitro</i> effect of different PRP concentrations on osteoblasts and fibroblasts (2005)

PRP preparations exert a dose-specific effect on oral FBs and OBs. Optimal results were observed at a platelet concentration of 2.5 x, which was approximately half of the maximal concentrate that could be obtained. Increased concentrations resulted in a reduction in proliferation and a suboptimal effect on OB function. Hence, different PRP concentrations may have an impact on the results that can be obtained in vivo.
Functional Characteristics of a Protective Monoclonal Antibody against Serotype A and C Lipooligosaccharides from <i>Moraxella catarrhalis</i> (2001)

A monoclonal antibody (MAb), designated MAb 8E7 (immunoglobulin G3), specific for Moraxella catarrhalis lipooligosaccharide (LOS) was evaluated for its functional activity in vitro and in a mouse model of colonization. Enzyme-linked immunosorbent assay (ELISA) demonstrated that the MAb 8E7 could be prepared to a high titer against LOS of the homologous strain 035E, and that it had bactericidal activity. MAb 8E7 reacted with M. catarrhalis serotype A and C LOSs but not serotype B LOS, as measured by ELISA and Western blotting. On the basis of published structures of LOSs, this suggests that the epitope recognized by MAb 8E7 is directed to a common sequence of either alpha-GlcNAc-(1-->2)-beta-Glc-(1--> at the branch substituting position 4 of the trisubstituted Glc residue or a terminal tetrasaccharide alpha-Gal-(1-->4)-beta-Gal-(1-->4)-alpha-Glc-(1-->2)-beta-Glc-(1--> at the branch substituting position 6 of the trisubstituted Glc residue. In a whole-cell ELISA, MAb 8E7 reacted with 70% of the 30 wild-type strains and clinical isolates tested. Immuno-electron microscopy demonstrated that MAb 8E7 reacted with a cell surface-exposed epitope of LOS on strain O35E. MAb 8E7 inhibited the adherence of strain O35E to Chang conjunctival epithelial cells by 90%. Passive immunization with MAb 8E7 could significantly enhance the clearance of strain O35E from mouse lungs in an aerosol challenge mouse model. This enhanced bacterial clearance was inhibited when MAb 8E7 was absorbed by M. catarrhalis serotype A LOS, indicating that the M. catarrhalis LOS-directed antibody may play a major role in the enhancement of M. catarrhalis clearance from lungs. These data suggest that MAb 8E7, which recognizes surface-exposed LOS of M. catarrhalis, is a protective antibody against M. catarrhalis.
Repeated use of GAL1 for gene disruption in Candida albicans. (1991)

A technique which has the potential to allow repeated use of the same selectable marker to create gene disruptions in Candida albicans has been developed. In this approach, originally described for Saccharomyces cerevisiae, the selectable marker is flanked by direct repeats. Mitotic recombination between these repeats leads to elimination of the selectable marker. A module in which the GALq1 gene is flanked by direct repeats of the bacterial CAT gene was constructed and used to disrupt one copy of the URA3 gene in a gal1 mutant. Gal- revertants were selected by plating on 2-deoxy-D-galactose (2DOG). The frequency of 2DOG-resistant colonies recovered was 20 times higher than that obtained with a similar construct not flanked by direct repeats. Of these, 20% had lost the GAL1 gene by recombination between the direct repeats. The GAL1 gene was used again to disrupt the remaining wild-type copy of the URA3 gene of one of these gal1 isolates, resulting in a stable ura3 mutant. This technique should be generally applicable to derive homozygous gene disruptions in this diploid organism.
Adaptive Scale Robust Segmentation for 2D Laser Scanner (2006)

This paper presents a robust algorithm for segmentation and line detection in 2D range scans. The described method exploits the multimodal probability density function of the residual error. It is capable of segmenting the range data in clusters, estimate the straight segments parameters, and estimate the scale of inliers error noise successfully, despite of high level of spurious data. No prior knowledge about the sensor and object properties is given to the algorithm. The mode seeking is based on mean shift algorithm, which has been widely used and tested in 3D laser scan segmentation, machine learning and pattern recognition applications. We show the reliability of the technique with experimental indoor and outdoor manmade environment. Compared with classical methods, a good compromise between false positive, false negative, wrong segment split and wrong segment merge is achieved, with improved accuracy in the estimated parameters.
Heart Preservation Using Continuous Ex Vivo Perfusion Improves Viability and Functional Recovery (2006)

Low-grade tissue acidosis and energy depletion occur during CS and are associated with oxidative injury and apoptosis during reperfusion. CP attenuates these biochemical and pathologic manifestations of tissue injury, together with improved myocardial recovery, despite mild, transient edema.
Association between exposure to farming, allergies and genetic variation in <i>CARD4</i> / <i>NOD1</i> (2006)

Polymorphisms in CARD4 significantly modify the protective effect of exposure to a farming environment.
Filling the Light Pipe (2010)

As data transmission rates continue to increase, optoelectronic engineers are developing techniques to deal with the approaching “capacity crunch.”
Identification of a Novel, Recurrent <scp>SLC44A1‐PRKCA</scp> Fusion in Papillary Glioneuronal Tumor (2012)

Mixed neuronal-glial tumors are rare and challenging to subclassify. One recently recognized variant, papillary glioneuronal tumor (PGNT), is characterized by prominent pseudopapillary structures and glioneuronal elements. We identified a novel translocation, t(9;17)(q31;q24), as the sole karyotypic anomaly in two PGNTs. A fluorescence in situ hybridization (FISH)-based positional cloning strategy revealed SLC44A1, a member of the choline transporter-like protein family, and PRKCA, a protein kinase C family member of serine/threonine-specific protein kinases, as the 9q31 and 17q24 breakpoint candidate genes, respectively. Reverse transcription-polymerase chain reaction (RT-PCR) analysis using a forward primer from SLC44A1 exon 5 and a reverse primer from PRKCA exon 10 confirmed the presence of a SLC44A1-PRKCA fusion product in both tumors. Sequencing of each chimeric transcript uncovered an identical fusion cDNA junction occurring between SLC44A1 exon 15 and PRKCA exon 9. A dual-color breakpoint-spanning probe set custom-designed for interphase cell recognition of the translocation event identified the fusion in a third PGNT. These results suggest that the t(9;17)(q31;q24) with the resultant novel fusion oncogene SLC44A1-PRKCA is the defining molecular feature of PGNT that may be responsible for its pathogenesis. The FISH and RT-PCR assays developed in this study can serve as valuable diagnostic adjuncts for this rare disease entity.
Evidential reasoning for object recognition (2003)

The authors present a framework to guide development of evidential reasoning in object recognition systems. Principles of evidential reasoning processes for open-world object recognition are proposed and applied to build evidential reasoning capabilities. The principles summarize research and findings by the authors up through the mid-1990s, including seminal results in object-centered computer vision, figure-ground discrimination, and the application of hierarchical Bayesian inference, Bayesian networks, and decision graphs to evidential reasoning for object recognition.
Enhancing Presentation Skills (1986)

“Presentation skills” often conjures up the picture of large groups, and the use, during training of peer group assessment via either live presentations or the use of closed circuit television. In this article the focus is on the presentation of a case to one person or a very small group, which is a more frequently needed skill by managers and professional staff.
Step-size selection for split-step based nonlinear compensation with coherent detection in 112-Gb/s 16-QAM transmission (2012)

Non-uniform step-size distribution is implemented for split-step based nonlinear compensation in singlechannel 112-Gb/s 16 quadrature amplitude modulation (QAM) transmission. Numerical simulations of the system including a 2080 km uncompensated link are performed using logarithmic step size distribution to compensate signal distortions. 50% of reduction in number of steps with respect to using constant step sizes is observed. The performance is further improved by optimizing nonlinear calculating position (NLCP) in case of using constant step sizes while NLCP optimization becomes unnecessary when using logarithmic step sizes, which reduces the computational effort due to uniformly distributed nonlinear phase for all successive steps.
Ring Transformation of Fused Pyridazines. III. 1-Substituted Phthalazines with Ynamines. (1995)

In the reaction of 1-substituted phthalazines with ynamines, there are three patterns of ring transformation, giving naphthalene derivatives through addition-cyclization-denitrogenation (type A), giving benzodiazocine derivatives through addition-cyclization-ring expansion (type B), and giving penta-substituted pyridine derivatives through N-N bond cleavage of the pyridazine ring (type C). In these reactions, it is considered that the substituent group at the 1-position of the phthalazine ring is a significant factor determining the outcome.
Nitroethylene yields (N,N-dihydroxyiminium)methylium dication in trifluoromethanesulfonic acid. Dications stabilized by Y delocalization (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitroethylene yields (N,N-dihydroxyiminium)methylium dication in trifluoromethanesulfonic acid. Dications stabilized by Y delocalizationTomohiko Ohwada, Akiko Itai, Toshiharu Ohta, and Koichi ShudoCite this: J. Am. Chem. Soc. 1987, 109, 23, 7036–7041Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November 1987https://pubs.acs.org/doi/10.1021/ja00257a022https://doi.org/10.1021/ja00257a022research-articleACS PublicationsRequest reuse permissionsArticle Views437Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Genetic Evidence for p75<sup>NTR</sup>-Dependent Tetraploidy in Cortical Projection Neurons from Adult Mice (2013)

A subpopulation of chick retinal projection neurons becomes tetraploid during development, an event prevented by blocking antibodies against p75 neurotrophin receptor (p75 NTR ). We have used an optimized flow cytometric assay, based on the analysis of unfixed brain cell nuclei, to study whether p75 NTR -dependent neuronal tetraploidization takes place in the cerebral cortex, giving rise to projection neurons as well. We show that 3% of neurons in both murine neocortex and chick telencephalic derivatives are tetraploid, and that in the mouse ∼85% of these neurons express the immediate early genes Erg-1 and c-Fos, indicating that they are functionally active. Tetraploid cortical neurons (65–80%) express CTIP2, a transcription factor specific for subcortical projection neurons in the mouse neocortex. During the period in which these neurons are born, p75 NTR is detected in differentiating neurons undergoing DNA replication. Accordingly, p75 NTR -deficient mice contain a reduced proportion of both NeuN and CTIP2-positive neocortical tetraploid neurons, thus providing genetic evidence for the participation of p75 NTR in the induction of neuronal tetraploidy in the mouse neocortex. In the striatum tetraploidy is mainly associated with long-range projection neurons as well since ∼80% of tetraploid neurons in this structure express calbindin, a marker of neostriatal-matrix spiny neurons, known to establish long-range projections to the substantia nigra and globus pallidus. In contrast, only 20% of tetraploid cortical neurons express calbindin, which is mainly expressed in layers II–III, where CTIP2 is absent. We conclude that tetraploidy mainly affects long-range projection neurons, being facilitated by p75 NTR in the neocortex.
CONTRIBUTION OF THE SURFACE LAYER TO THE SEEING AT SAN PEDRO M ARTIR: SIMULTANEOUS MICROTHERMAL AND DIMM MEASUREMENTS (2003)

Reportamos medidas de la contribucion de la capa supercial al seeing en el Observatorio Astronomico Nacional de San Pedro Martir (OAN{SPM). Utilizamos un mastil instrumentado con sensores de temperatura microdiferenciales localizados en 7 niveles para medir la constante de estructura del indice de refraccion C2 n en los primeros 15-m. El parametro de distorsion de la imagen (llamado comunmente seeing) integrado se determino utilizando un Monitor Diferencial de Movimiento de Imagen durante 23 noches. Se encontro una estadstica log{normal con valores promedio de 0.9800 y de mediana 0.8400. La contribucion de la capa supercial (2.3 a 15-m) a la turbulencia optica total tiene un valor promedio de 16%, lo cual corresponde a una degradacion de 10% del seeing total. Estos valores son similares a los encontrados en otros observatorios en el mundo, lo que sugiere que la presencia de arboles en el sitio del OAN{SPM no afecta de manera considerable el seeing debido a la capa supercial. Se requieren mas estudios para conrmar esta tendencia.
A single amino acid substitution in rhodopsin (lysine 248—-leucine) prevents activation of transducin. (1988)

In structure-function studies on bovine rhodopsin by in vitro site-specific mutagenesis, we have prepared three mutants in the cytoplasmic loop between the putative transmembrane helices E and F. In each mutant, charged amino acid residues were replaced by neutral residues: mutant 1, Glu239----Gln; mutant 2, Lys248----Leu; and mutant 3, Glu247----Gln, Lys248----Leu, and Glu249----Gln. The mutant rhodopsin genes were expressed in monkey kidney (COS-1) cells. After the addition of 11-cis-retinal to the cells, the rhodopsin mutants were purified by immunoaffinity adsorption. Each mutant gave a wild-type rhodopsin visible absorption spectrum. The mutants were assayed for their ability to stimulate the GTPase activity of transducin in a light-dependent manner. While mutants 1 and 3 showed wild-type activity, mutant 2 (Lys248----Leu) was inactive.
Atomic structure of the interface between SrTiO3 thin films and Si(001) substrates (2008)

The structure of the SrTiO3/Si interface is determined by high-angle annular dark field imaging in combination with a recently developed technique based on aberration-corrected high-resolution transmission electron microscopy. At the interface, a monolayer of SrO faces the terminating plane of silicon. In this monolayer, the strontium atoms lie above the face-center of four silicon atoms in the terminating plane, and the oxygen atoms are located directly above the terminating silicon atoms. This structure, which is the dominant type of interface structure observed in this system, agrees with one of the interface structures predicted by first-principles calculations.
Personalized Handling of Semantic Data with MIG (2009)

This paper shows a semantically-enabled Web application named MIG used to create user profiles which enhances users accessibility by allowing the creation of an user interface adapted to the user needs, the device used, and its preferences. This approach exploits the Semantic Web technologies and the infrastructure and applications created in previous work.
Lineage Selection of Functional and Cryopreservable Human Embryonic Stem Cell-Derived Neurons (2008)

A major prerequisite for the biomedical application of human embryonic stem cells (hESC) is the derivation of defined and homogeneous somatic cell types. Here we present a human doublecortin (DCX) promoter-based lineage-selection strategy for the generation of purified hESC-derived immature neurons. After transfection of hESC-derived neural precursors with a DCX-enhanced green fluorescent protein construct, fluorescence-activated cell sorting enables the enrichment of immature human neurons at purities of up to 95%. Selected neurons undergo functional maturation and are able to establish synaptic connections. Considering that the applicability of purified hESC-derived neurons would largely benefit from an efficient cryopreservation technique, we set out to devise defined freezing conditions involving caspase inhibition, which yield post-thaw recovery rates of up to 83%. Combined with our lineage-selection procedure this cryopreservation technique enables the generation of human neurons in a ready-to-use format for a large variety of biomedical applications.
Predicting the risk of readmission of diabetic patients using MapReduce (2014)

From the banking to retail, many sectors have already embraced big data regardless of whether the information comes from public or private sources. In the clinical sphere, the amount of patient data has grown exponentially because of computer based information systems. E-Health monitoring applications have some particularities concerning the importance on data quality. This paper presents a novel solution using Hadoop Mapreduce to analyze large datasets and extract useful insights from the dataset which helps doctors to effectively allocate resources. The successful healthcare delivery and planning strongly rely on data (e.g. sensed data, diagnosis, administration information); the higher quality of the data, the better will be the patient assistance. The applications are also particularly exposed to a contextual environment (i.e., patient's mobility, communication technologies, performance, information heterogeneity, etc.) that has an important impact on information management and application achievement. The main objective of our system is to predict the risk of diabetic patients for readmission in the next 30 days by measuring the probability using MapReduce. This risk score helps the physicians in recommending appropriate care for the patients.
New Building Blocks for Fluorinated Imidazole Derivatives:  Preparation of β-Fluoro- and β,β-Difluorohistamine (2001)

We demonstrate that "FBr" addition to 1-trityl-4-vinyl-1H-imidazole (7) provides a convenient route to side-chain-fluorinated histamines. Thus, addition of "FBr" to the double bond of 7 occurs with Markovnikov regioselectivity to produce 4-(2-bromo-1-fluoroethyl)-1-trityl-1H-imidazole (8). Substitution with azide, reduction, and removal of the trityl group provide beta-fluorohistamine (1) as the dihydrochloride. Elimination of HBr from 8 followed by a second addition of "FBr" gives 4-(2-bromo-1,1-difluoroethyl)-1-trityl-1H-imidazole (15). This was similarly converted to beta,beta-difluorohistamine (2) as the dihydrochloride.
Scene-library-based video coding scheme exploiting long-term temporal correlation (2017)

In movies and TV shows, it is common that several scenes repeat alternately. These videos are characterized with the long-term temporal correlation, which can be exploited to improve video coding efficiency. However, in applications supporting random access (RA), a video is typically divided into a number of RA segments (RASs) by RA points (RAPs), and different RASs are coded independently. In such a way, the long-term temporal correlation among RASs with similar scenes cannot be used. We present a scene-library-based video coding scheme for the coding of videos with repeated scenes. First, a compact scene library is built by clustering similar scenes and extracting representative frames in encoding video. Then, the video is coded using a layered scene-library-based coding structure, in which the library frames serve as long-term reference frames. The scene library is not cleared by RAPs so that the long-term temporal correlation between RASs from similar scenes can be exploited. Furthermore, the RAP frames are coded as interframes by only referencing library frames so as to improve coding efficiency while maintaining RA property. Experimental results show that the coding scheme can achieve significant coding gain over state-of-the-art methods.
Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway (2011)

Arctigenin is a dibenzylbutyrolactone lignan isolated from Bardanae fructus, Arctium lappa L, Saussureamedusa, Torreya nucifera, and Ipomea cairica. It has been reported to exhibit anti-inflammatory activities, which is mainly mediated through its inhibitory effect on nuclear transcription factor-kappaB (NF-κB). But the role of arctigenin in JAK-STAT3 signaling pathways is still unclear. In present study, we investigated the effect of arctigenin on signal transducer and activator of transcription 3 (STAT3) pathway and evaluated whether suppression of STAT3 activity by arctigenin could sensitize cancer cells to a chemotherapeutic drug cisplatin. Our results show that arctigenin significantly suppressed both constitutively activated and IL-6-induced STAT3 phosphorylation and subsequent nuclear translocation in cancer cells. Inhibition of STAT3 tyrosine phosphorylation was found to be achieved through suppression of Src, JAK1, and JAK2, while suppression of STAT3 serine phosphorylation was mediated by inhibition of ERK activation. Pervanadate reversed the arctigenin-induced downregulation of STAT3 activation, suggesting the involvement of a protein tyrosine phosphatase. Indeed, arctigenin can obviously induce the expression of the PTP SHP-2. Furthermore, the constitutive activation level of STAT3 was found to be correlated to the resistance of cancer cells to cisplatin-induced apoptosis. Arctigenin dramatically promoted cisplatin-induced cell death in cancer cells, indicating that arctigenin enhanced the sensitivity of cancer cells to cisplatin mainly via STAT3 suppression. These observations suggest a novel anticancer function of arctigenin and a potential therapeutic strategy of using arctigenin in combination with chemotherapeutic agents for cancer treatment. J. Cell. Biochem. 112: 2837–2849, 2011. © 2011 Wiley-Liss, Inc.