gebhart/patrepeval huggingface dataset:
MDA-7/IL-24-Based Cancer Gene Therapy: Translation from the Laboratory to the Clinic (2006)

Despite recent advances in treatment strategies, the overall 5-year survival rate for patients with common epithelial cancers is poor largely because of the difficulty in treating metastatic cancers. Therefore, therapeutic agents are urgently needed that can effectively inhibit both primary epithelial tumors and their metastases. One such agent that has shown promise in preclinical studies is the tumor suppressor/cytokine, melanoma differentiation associated gene-7 also known as interleukin-24 (mda-7/IL-24). Preclinical studies from our and other laboratories have shown that overexpression of MDA-7/IL-24 causes a strong tumor- suppressive effect in many human cancer cells but spares normal cells. This gene therapy also enhances the tumor-suppressive activity of radiotherapy and chemotherapy. Secreted MDA-7 protein that is glycosylated also has been shown to have potent antiangiogenic activity both in vitro and in vivo. Studies examining the immune properties of mda-7 have shown that MDA-7/IL-24 unlike the related IL-10, functions as a Th1 cytokine. Recently, an MDA-7 protein-mediated "bystander effect" on tumor cells has been documented. Building on these findings we successfully completed a Phase I clinical trial of adenovirus-based mda-7 cancer therapy that confirmed the safety of this gene therapy. Phase II trials evaluating the efficacy of mda-7-based gene therapy are warranted. The outcome of such ongoing mda-7-based gene therapy trials will allow us to better understand this therapy's clinical utility.
The impact of lot-to-lot and wafer-to-wafer variations on SPC (2002)

In this paper we point out that the application of standard SPC charts for process control during wafer fabrication could lead to errors due to the presence of the lot-to-lot and wafer-to-wafer variations. We illustrate that the error could increase the "lots-at-risk" by as much as 17%. We present a new SPC model which accounts for the lot-to-lot and wafer-to-wafer variations. Then, we present an adaptive sequential two-lot control policy, where we sample the successive lot when there is an out-of-control signal, and investigate for the process shift only when the successive lot also gives an out-of-control signal. This adaptive method outperforms the static policy as long as the lot-to-lot variance is smaller than the wafer-to-wafer variance. However, when the wafer-to-wafer variance is higher than the lot-to-lot variance, the information from a successive lot is less variance than the information from additional wafers in the same lot.
Preparation of 3‐hydroxy‐ and 3‐methoxy‐<i>N</i>‐heteroaryl‐2‐methyl‐4‐pyridones (1993)

Abstract A number of new 3‐hydroxy‐ and 3‐methoxy‐2‐methyl‐4‐pyridones substituted on the nitrogen atom with selected heterocycles has been prepared. Novel chelating properties of the hydroxy‐compounds are expected.
Phase-plane analysis of left ventricular chamber filling and midwall fiber lengthening in patients with left ventricular hypertrophy. (1987)

Echocardiographic measurements of the left ventricle were used to define rates of circumferential fiber lengthening at the endocardium and midwall in 12 normal subjects and six patients with concentric left ventricular hypertrophy (wall thickness 11 to 16 mm). There was no difference in chamber size and systolic shortening in the two groups, but peak normalized lengthening rate [endocardial (+) VCF] was less than normal in the group with hypertrophy (4.8 +/- 1.4 and 3.1 +/- 0.9 sec-1, respectively, p less than .05). These results were contrasted with midwall (+) VCF data derived from two models that take into account nonuniform thickening across the left ventricular wall. Both models assume a constant left ventricular mass. The first allows changes in long axis and muscle cross-sectional area; the second assumes a constant cross-sectional area. Peak midwall (+) VCF with the first model was 2.1 +/- 0.5 sec-1 in the normal group and 1.4 +/- 0.3 sec-1 in the group with hypertrophy (p less than .01); with the second model peak midwall VCF was 2.8 +/- 0.6 and 1.4 +/- 0.4 sec-1 (p less than .01) in the two groups. The time to peak VCF and the dimension at the instant of peak (+) VCF were similar in the two groups. Phase-plane plots of length and velocity (dimension vs dD/dt) allow visual inspection and quantification of the relationships between instantaneous dimension, rate of change of dimension, and time in normal and hypertrophic hearts. These plots indicate abnormal filling of the left ventricular chamber and lengthening of midwall fibers in left ventricular hypertrophy.
Complete regio- and stereospecificity in the Lewis acid catalyzed Diels-Alder reactions of (Z)-2-methoxy-1-(phenylthio)-1,3-butadienes. Conversion of the CS configuration of an adduct to the CC configuration at the allylic position by a [2,3] sigmatropic rearrangement (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplete regio- and stereospecificity in the Lewis acid catalyzed Diels-Alder reactions of (Z)-2-methoxy-1-(phenylthio)-1,3-butadienes. Conversion of the CS configuration of an adduct to the CC configuration at the allylic position by a [2,3] sigmatropic rearrangementTheodore Cohen and Zenyk KosarychCite this: J. Org. Chem. 1982, 47, 20, 4005–4008Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://pubs.acs.org/doi/10.1021/jo00141a047https://doi.org/10.1021/jo00141a047research-articleACS PublicationsRequest reuse permissionsArticle Views850Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Diversity of the Human Allergen-Specific T Cell Repertoire Associated with Distinct Skin Test Reactions: Delayed-Type Hypersensitivity-Associated Major Epitopes Induce Th1- and Th2-Dominated Responses (2001)

Distinct immune responses in humans to the Trichophyton rubrum Ag, Tri r 2, are associated with different patterns of T cell epitope recognition based on in vitro proliferation to peptides derived from this 29-kDa protein. Specifically, the amino-terminal immunodominant epitope, peptide 5 (P5), stimulates strong T cell proliferative responses in subjects with delayed (DTH), but not immediate (IH) hypersensitivity skin tests. Evidence of a role for cytokines or changes in epitope recognition over time was examined in responses to Trichophyton using primary PBMC cultures established from seven IH and seven DTH subjects. Responses stimulated by Tri r 2 were dominated by the Th1 cytokine IFN-gamma (IFN-gamma:IL-5 > or = 4:1) in five DTH subjects, even in the presence of Th2-dominated responses (IFN-gamma:IL-5 < or = 3:1) to a subset of major epitopes. Paradoxically, P5 induced IL-5 and IL-10 production in DTH, but not IH subjects (p = 0.003 (IL-5), p = 0.024 (IL-10)), with no significant difference in IFN-gamma levels between the two groups. In cultures from IH responders, no IL-5 was measurable after stimulation with P6 and P7 (as well as P5); this region of the molecule was shown previously to stimulate markedly reduced T cell proliferation in these individuals. Repeat proliferation assays confirmed no change in the pattern of peptide recognition after > or =20 mo in IH or DTH subjects. We conclude that T cell repertoires associated with distinct immune responses to Tri r 2 can be distinguished based on Th2 cytokine induction by DTH-associated major epitopes localizing to the amino-terminal region of the molecule.
ChemInform Abstract: Applied Chemistry of Natural DNA (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Revenue Management in a Dynamic Network Environment (2003)

We investigate dynamic policies for allocating scarce inventory to stochastic demand for multiple fare classes, in a network environment so as to maximize total expected revenues. Typical applications include sequential reservations for an airline network, hotel, or car rental service. We propose and analyze a new algorithm based on approximate dynamic programming, both theoretically and computationally. This algorithm uses adaptive, nonadditive bid prices from a linear programming relaxation. We provide computational results that give insight into the performance of the new algorithm and the widely used bid-price control, for several networks and demand scenarios. We extend the proposed algorithm to handle cancellations and no-shows by incorporating oversales decisions in the underlying linear programming formulation. We report encouraging computational results that show that the new algorithm leads to higher revenues and more robust performance than bid-price control.
Application of Taguchi methods to propulsion system optimization forSSTO vehicles (1992)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Observations on the mines of oak-feeding species of Phyllonorycter (Lep.: Gracillariidae) (1978)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Host MHC class II+ antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions (2006)

Following bone marrow transplantation, delayed donor leukocyte infusions (DLIs) can induce graft-versus-leukemia (GVL) effects without graft-versus-host disease (GVHD). These antitumor responses are maximized by the presence of host hematopoietic antigen-presenting cells (APCs) at the time of DLI. Using a tumor-protection model, we demonstrate here that GVL activity following administration of DLIs to established mixed chimeras is dependent primarily on reactivity to allogeneic MHC antigens rather than minor histocompatibility or tumor-associated antigens. CD8(+) T-cell-dependent GVL responses against an MHC class II-negative tumor following delayed DLI require CD4(+) T-cell help and are reduced significantly when host APCs lack MHC class II expression. CD4(+) T cells primed by host APCs were required for maximal expansion of graft-versus-host reactive CD8(+) T cells but not their synthesis of IFN-gamma. In contrast, the GVL requirement for CD4(+) T-cell help was bypassed almost completely when DLI was administered to freshly irradiated recipients, indicating that the host environment is a major factor influencing the cellular mechanisms of GVL.
Sacred Space: Where Possibilities Abound and Change Is Engendered (2008)

We begin this article with the premise that "each human being has a wellspring of innate intelligence from which deep qualities like presence, wisdom, common sense, resiliency, and peace of mind emerge." To access that innate intelligence, we coaches learn to create a space for ourselves and for the leaders we coach. We call this sacred space.KeywordsHarvard Business ReviewReflective LearningYoga ClassSacred SpacePopular PracticeThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Effect of ingestion order of the fat component of a solid meal on intragastric fat distribution and gastric emptying assessed by MRI (2005)

Meal ingestion order influences GE and intragastric distribution of fat, which can be assessed by MRI techniques, providing new insights into the physiology of gastric processing and intragastric distribution of different meal phases.
SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis (2017)

Distant metastasis is the main cause of breast cancer-related death; however, effective therapeutic strategies targeting metastasis are still scarce. This is largely attributable to the spatiotemporal intratumor heterogeneity during metastasis. Here we show that protein deacetylase SIRT7 is significantly downregulated in breast cancer lung metastases in human and mice, and predicts metastasis-free survival. SIRT7 deficiency promotes breast cancer cell metastasis, while temporal expression of Sirt7 inhibits metastasis in polyomavirus middle T antigen breast cancer model. Mechanistically, SIRT7 deacetylates and promotes SMAD4 degradation mediated by β-TrCP1, and SIRT7 deficiency activates transforming growth factor-β signaling and enhances epithelial-to-mesenchymal transition. Significantly, resveratrol activates SIRT7 deacetylase activity, inhibits breast cancer lung metastases, and increases survival. Our data highlight SIRT7 as a modulator of transforming growth factor-β signaling and suppressor of breast cancer metastasis, meanwhile providing an effective anti-metastatic therapeutic strategy.Metastatic disease is the major reason for breast cancer-related deaths; therefore, a better understanding of this process and its players is needed. Here the authors report the role of SIRT7 in inhibiting SMAD4-mediated breast cancer metastasis providing a possible therapeutic avenue.
DEBUGGING DISTRIBUTED COMPUTATIONS IN A NESTED ATOMIC ACTION SYSTEM (1984)

Concurrent and distributed programs are hard to debug. This thesis agues that structuring activities as nested atomic actions can make debugging such programs much like debugging traditional sequential programs. To support the argument, the author presents a method for debugging computations in the Argus language and system. Her method is applicable to other action systems since it depends only on the atomicity properties of actions. To debug a computation in our method, the user inspects a serial execution that is equivalent to the original computation. The debugging process involves two phases. In the first phase, the user examines pre- and post- states of actions to isolate the action that exposes the bug. In the second phase, the debugging system re-executes code to reproduce the details of the culprit action. The user can repeat this re-execution and can use standard break-and-examine tools on it to isolate the bug. This debugging system supports the method by saving a partial history when an action runs. This history consists mainly of recovery versions of objects. The system also timestamps the termination of actions so it can determine from the saved versions the values of objects in an action's pre- and post- states. The debugging system itself uses pre-states to repeat actions. This thesis presents the first detailed design that ues recovery versions and timestamps for debugging. (Author)
Data flow analysis of embedded program expressions (2012)

Data flow analysis techniques can be used to help assess threats to data confidentiality and integrity in security critical program code. However, a fundamental weakness of static analysis techniques is that they overestimate the ways in which data may propagate at run time. Discounting large numbers of these false-positive data flow paths wastes an information security evaluator's time and effort. Here we show how to automatically eliminate some false-positive data flow paths by precisely modelling how classified data is blocked by certain expressions in embedded C code. We present a library of detailed data flow models of individual expression elements and an algorithm for introducing these components into conventional data flow graphs. The resulting models can be used to accurately trace byte-level or even bit-level data flow through expressions that are normally treated as atomic. This allows us to identify expressions that safely downgrade their classified inputs and thereby eliminate false-positive data flow paths from the security evaluation process. To validate the approach we have implemented and tested it in an existing data flow analysis toolkit.
A Ratiometric Two-Photon Fluorescent Probe Reveals Reduction in Mitochondrial H<sub>2</sub>S Production in Parkinson’s Disease Gene Knockout Astrocytes (2013)

Hydrogen sulfide (H2S) is a multifunctional signaling molecule that exerts neuroprotective effects in oxidative stress. In this article, we report a mitochondria-localized two-photon probe, SHS-M2, that can be excited by 750 nm femtosecond pulses and employed for ratiometric detection of H2S in live astrocytes and living brain slices using two-photon microscopy (TPM). SHS-M2 shows bright two-photon-excited fluorescence and a marked change in emission color from blue to yellow in response to H2S, low cytotoxicity, easy loading, and minimum interference from other biologically relevant species including reactive sulfur, oxygen, and nitrogen species, thereby allowing quantitative analysis of H2S levels. Molecular TPM imaging with SHS-M2 in astrocytes revealed that there is a correlation between the ratiometric analysis and expression levels of cystathionine β-synthase (CBS), the major enzyme that catalyzes H2S production. In studies involving DJ-1, a Parkinson's disease (PD) gene, attenuated H2S production in comparison with wild-type controls was observed in DJ-1-knockout astrocytes and brain slices, where CBS expression was decreased. These findings demonstrate that reduced H2S levels in astrocytes may contribute to the development of PD and that SHS-M2 may be useful as a marker to detect a risk of neurodegenerative diseases, including PD.
The Effects of GLCM parameters on LAI estimation using texture values from Quickbird Satellite Imagery (2017)

When the leaf area index (LAI) of a forest reaches 3, the problem of spectrum saturation becomes the main limitation to improving the accuracy of the LAI estimate. A sensitivity analysis of the Grey Level Co-occurrence Matrix (GLCM) parameters which can be applied to satellite image processing and analysis showed that the most important parameters included orientation, displacement and moving window size. We calculated the values of Angular Second Moment (ASM), Entropy (ENT), Correlation (COR), Contrast (CON), Dissimilarity (DIS) and Homogeneity (HOM) from Quickbird panchromatic imagery using a GLCM method. Four orientations, seven displacements and seven window sizes were considered. An orientation of 90° was best for estimating the LAI of black locust forest, regardless of moving window size, displacement and texture parameters. Displacements of 3 pixels appeared to be best. The orientation and window size had only a little influence on these settings. The highest adjusted r<sup>2</sup> values were obtained using a 3 × 3 moving window size for ASM and ENT. The tendency of CON, COR, DIS and HOM to vary with window size was significantly affected by orientation. This study can help with parameter selection when texture features from high resolution imagery are used to estimate broad-leaved forest structure information.
A new lease of life for an old enzyme (1996)

We review here some recent data about glucose-6-phosphate dehydrogenase (G6PD), the first and key regulatory enzyme of the pentose phosphate pathway. New evidence has been presented to suggest that malaria is a selective agent for G6PD deficiency, which is the most common enzymopathy in man, and that G6PD deficiency, generally considered to be a mild and benign condition, is significantly disadvantageous in certain environmental conditions. At the molecular level, the enzyme structure has recently been elucidated and mechanisms regulating G6PD gene expression have been determined. A G6PD knock-out mutation introduced in mouse cells makes them exquisitely sensitive to oxidative stress, indicating that this ubiquitous metabolic enzyme has a major role in the defence against oxidative stress, even in eukaryotic nucleated cells, which have several alternative routes for providing the same protection. Because of the high prevalence of G6PD deficiency in many populations, it is expected that these findings will prompt further studies to ascertain the putative role of G6PD deficiency in conditions such as carcinogenesis and ageing.
Highly Enantio‐ and Diastereoselective Construction of 1,2‐Disubstituted Cyclopentane Compounds by Dirhodium(II) Tetrakis[<i>N</i>‐phthaloyl‐(<i>S</i>)‐<i>tert</i>‐leucinate]‐Catalyzed CH Insertion Reactions of α‐Diazo Esters (2005)

Abstract A highly enantio‐ and diastereoselective intramolecular CH insertion reaction of α‐diazo esters has been achieved with the use of dirhodium(II) tetrakis[ N ‐phthaloyl‐( S )‐ tert ‐leucinate] as a catalyst, providing exclusively cis ‐2‐arylcyclopentane‐1‐carboxylates in up to 95% ee with no evidence of alkene formation.
Synthesen in der Reihe der Sexualhormone (1936)

Seite 10.Verseifung des 4-Methyl-4-cyan-heptan-l, 5,7-tricarbonesters und Ver esterung mit Diazomethan 42 11.Cyclisierung des 4-Methyl-4-cyan-heptan-l, 5,7-tricarbonesters mit Natrium 42 12. a-Brom-und a-Jod-adipinsure-dithylester 43 13.Darstellung des Lactones C16H2606 durch Kondensation von a-Brom- adipinester mit y-Acetylbutterester nach Reformatsky 43 14.Aufspaltung des Lactones C16H2606 mit Kaliumcyanid 44 15.Verseifung des Nitriles von Versuch 14 mittels HBr 45 16.Gleichzeitige Nitrilverseifung und Veresterung 45 17.Darstellung von m-Amino-benzyl-alkohol 46 18. Darstellung von m-Oxy-benzyl-alkohol COOR CH
Are there teratogenic risks associated with antidotes used in the acute management of poisoned pregnant women? (2003)

Despite the limited evidence supporting the risk of antidote use during pregnancy, antidotes should be used when there is a clear maternal indication to decrease the morbidity or mortality associated with poisoning. The only exception may be penicillamine, which is a teratogen. Better antidotes exist for most poisonings that penicillamine could potentially treat. At this time, there is no known fetal indication for all antidotes. Reporting the use of an antidote during pregnancy should be encouraged, especially if used during the critical period of organogenesis.
A Study on Thermal Deformation Compensation in the Molding of Aspheric Glass Lenses (2010)

Recently, due to the tremendous growth of media technology, demands of the aspheric glass lens which is a high-performance and miniaturized increase gradually. Generally, the aspheric glass lens is manufactured by Glass Molding Press (GMP) method using tungsten carbide (WC) mold core. In this study, the thermal deformation which was occurred by GMP process was analyzed and applied it to compensate the aspheric glass lens. The compensated lens was satisfied that can be applied to the actual specifications.