gebhart/patrepeval huggingface dataset:
Aerogel Microspheres from Natural Cellulose Nanofibrils and Their Application as Cell Culture Scaffold (2014)

We demonstrated that ultralight pure natural aerogel microspheres can be fabricated using cellulose nanofibrials (CNF) directly. Experimentally, the CNF aqueous gel droplets, produced by spraying and atomizing through a steel nozzle, were collected into liquid nitrogen for instant freezing followed by freeze-drying. The aerogel microspheres are highly porous with bulk density as low as 0.0018 g cm(-3). The pore size of the cellulose aeogel microspheres ranges from nano- to macrometers. The unique ultralight and high porous structure ensured high moisture (~90 g g(-1)) and water uptake capacity (~100 g g(-1)) of the aerogel microspheres. Covalent cross-linking between the native nanofibrils and cross-linkers made the aerogel microspheres very stable even in a harsh environment. The present study also confirmed this kind of aerogel microspheres from native cellulose fibers can be used as cell culture scaffold.
stdchk: A Checkpoint Storage System for Desktop Grid Computing (2007)

Checkpointing is an indispensable technique to provide fault tolerance for long-running high-throughput applications like those running on desktop grids. This paper argues that a dedicated checkpoint storage system, optimized to operate in these environments, can offer multiple benefits: reduce the load on a traditional file system, offer high-performance through specialization, and, finally, optimize data management by taking into account checkpoint application semantics. Such a storage system can present a unifying abstraction to checkpoint operations, while hiding the fact that there are no dedicated resources to store the checkpoint data. We prototype stdchk, a checkpoint storage system that uses scavenged disk space from participating desktops to build a low-cost storage system, offering a traditional file system interface for easy integration with applications. This paper presents the stdchk architecture, key performance optimizations, support for incremental checkpointing, and increased data availability. Our evaluation confirms that the stdchk approach is viable in a desktop grid setting and offers a low cost storage system with desirable performance characteristics: high write throughput and reduced storage space and network effort to save checkpoint images.
Additive effect of three noradrenergic genes (<i>ADRA2A</i>, <i>ADRA2C</i>, <i>DBH</i>) on attention‐deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects (1999)

Halperin et al. (Halperin JM. Newcorn JH, Koda VH, Pick L, McKay KE, Knott P. Noradrenergic mechanisms in ADHD children with and without reading disabilities: a replication and extension. J Am Acad Child Adolesc Psychiatry 1997: 36: 1688 1696) reported a significant increase in plasma norepinephrine (NE) in attention-deficit hyperactivity disorder (ADHD) children with reading and other cognitive disabilities compared to ADHD children without learning disabilities (LD). We examined the hypothesis that ADHD + LD was associated with NE dysfunction at a molecular genetic level by testing for associations and additive effects between polymorphisms at three noradrenergic genes the adrenergic alpha2A receptor (ADRA2A), adrenergic alpha2C receptor (ADRA2C), and dopamine beta-hydroxylase (DBH) genes. A total of 336 subjects consisting of 274 individuals with Tourette syndrome (TS) and 62 normal controls were genotyped. Regression analysis showed a significant correlation between scores for ADHD, a history of LD, and poor grade-school academic performance that was greatest for the additive effect of all three genes. Combined, these three genes accounted for 3.5% of the variance of the ADHD score (p = 0.0005). There was a significant increase in the number of variant NE genes progressing from subjects without ADHD (A-) or learning disorders (LD-) to A + LD - to A - LD + to A + LD + (p = 0.0017), but no comparable effect for dopamine genes. These data support an association between NE genes and ADHD, especially in ADHD + LD subjects.
Giant fusiform intracranial aneurysms: review of 120 patients treated surgically from 1965 to 1992 (1997)

The paucity of information about giant fusiform intracranial aneurysms prompted this review of 120 surgically treated patients. Twenty-five aneurysms were located in the anterior and 95 in the posterior circulation. Six patients suffered from atherosclerosis and only three others had a known arteriopathy. The remaining 111 patients presented with aneurysms resulting from an unknown arterial disorder; these patients were much younger than those harboring atherosclerotic aneurysms. Mass effect occurred in only 50% of cases and hemorrhage in 20%. Eight aneurysms caused transient ischemic attacks. Hunterian proximal occlusion or trapping were dominant among the treatment methods. In contrast to the management of giant saccular aneurysms, the usual thrombotic occlusion of a giant fusiform aneurysm after proximal parent artery occlusion requires the presence of two collateral circulations to prevent infarction, one for the end vessels and another for the perforating vessels that arise from the aneurysm. Although there was some reliance on the circle of Willis and on collateral vessels manufactured at surgery, the extent of natural leptomeningeal and perforating collateral, thalamic, lenticulostriate, and brainstem vessels was astonishing and formerly unknown to the authors. Good outcome occurred in 76% of patients with aneurysms in the anterior circulation; two of the six cases with poor results included patients who were already hemiplegic. Ninety percent of patients with posterior cerebral aneurysms fared well. Only 67% of patients with basilar or vertebral aneurysms had good outcomes, although more (17%) of these patients were in poor condition preoperatively because of brainstem compression.
Extracellular DNA Plays a Key Role in Deep-Sea Ecosystem Functioning (2005)

The ecological role and biogeochemical relevance of extracellular DNA in the oceanic sediments are unknown. Our global estimates indicate that up to 0.45 gigatons of extracellular DNA are present in the top 10 centimeters of deep-sea sediments, representing the largest reservoir of DNA in the world oceans. We demonstrate that extracellular DNA accounts for about one fifth of the total organic phosphorus regeneration and provides almost half of the prokaryotic demand for organic phosphorus. It therefore plays a key role in deep-sea ecosystem functioning on a global scale.
Efficient quasiparticle traps with low dissipation through gap engineering (2019)

Quasiparticles represent an intrinsic source of perturbation for superconducting qubits, leading to both dissipation of the qubit energy and dephasing. Recently, it has been shown that normal-metal traps may efficiently reduce the quasiparticle population and improve the qubit lifetime, provided the trap surpasses a certain characteristic size. Moreover, while the trap itself introduces new relaxation mechanisms, they are not expected to harm state-of-the-art transmon qubits under the condition that the traps are not placed too close to extremal positions where electric fields are high. Here we study a different type of trap, realized through gap engineering. We find that gap-engineered traps relax the remaining constraints imposed on normal metal traps. First, the characteristic trap size, above which the trap is efficient, is reduced with respect to normal metal traps, such that here, strong traps are possible in smaller devices. Second, the losses caused by the trap are now greatly reduced, providing more flexibility in trap placement. The latter point is of particular importance, since for efficient protection from quasiparticles, the traps ideally should be placed close to the active parts of the qubit device, where electric fields are typically high.
Critical Views of Qualification Studies and Pre-Exams for 2009 Korea School Math Teacher Appointment-Proportion of Issued Problems of Probability and Statistics (2008)

2009 year new execution of appointments for secondary school teachers was announced at 2004 year by Ministry of Education. The new school teacher appointment has been developed and studied in various aspects of appropriate qualification for good school teacher. In the results of the studies by Korea School Mathematics Education Association and pre-exams by Korea Institute for Curriculum and Evaluation, the Probability and Statistics chapters are less revaluated as 7.5-10%, but we argue those more than 15% as along with our recent Korean school texts reviews(Lee, et al., 2005).
Order Acceptance with Reinforcement Learning (2001)

Order Acceptance (OA) is one of the main functions in a business control framework. Basically, OA involves for each order a 0/1 (i.e., reject/accept) decision. Always accepting an order when capacity is available could unable the system to accept more convenient orders in the future. Another important aspect is the aV'(tiiability of information to the decisionmaker. We use a stochastic modeling approach using Markov decision theory and learning methods from Artificial Intelligence techniques in order to deal with uncertainty and long-term decisions in Ok Reinforcement Learning (RL) is a quite new approach that already combines this idea of modeling and solution method. Here we report on RL-solutions for some OA models.
Organic spintronics (2007)

We review the emerging field of organic spintronics, where organic materials are applied as a medium to transport and control spin-polarized signals. The contacts for injecting and detecting spins are formed by ferromagnetic metals, oxides, or inorganic semiconductors. First, the basic concepts of spintronics and organic electronics are addressed, and phenomena which are in particular relevant for organic spintronics are highlighted. Experiments using different organic materials, including carbon nanotubes, organic thin films, self-assembled monolayers and single molecules are then reviewed. Observed magnetoresistance points toward successful spin injection and detection, but spurious magnetoresistance effects can easily be confused with spin accumulation. A few studies report long spin relaxation times and lengths, which forms a promising basis for further research. We conclude with discussing outstanding questions and problems.
SEPARATE ROLES OF ANDROGEN AND OESTROGEN IN THE MANIPULATION OF GROWTH AND EFFICIENCY OF FOOD UTILIZATION IN FEMALE RATS (1979)

The roles of androgen and oestrogen in the perinatal and postpubertal stages of development on the masculinization of female patterns of growth have been investigated in several experiments in rats. A stimulatory effect of testosterone on subsequent growth and efficiency of food utilization was only observed when administered perinatally to intact females as the propionate ester. Thus females which were untreated (or androgenized) perinatally and ovariectomized at weaning failed to grow more rapidly or utilize food more efficiently when treated with mixed testosterone esters from 36 to 38 days of age. Also autoimmunity to luteinizing hormone releasing hormone (LH-RH) had little effect on the growth or efficiency of food utilization of male rats, although testicular development was grossly affected. An inhibitory effect of oestrogen on subsequent growth and efficiency of food utilization was demonstrated by surgical ovariectomy and by autoimmunity to LH-RH. Also perinatal administration of oestradiol benzoate to intact female rats depressed growth below that of untreated intact litter-mate females until about 50 days of age. Then oestradiol benzoate-treated female rats grew to a larger size than untreated intact litter-mates but not to a heavier weight than untreated litter-mate females which like the oestradiol benzoate-treated females, were ovariectomized at 18-21 days of age. Both of these groups of female rats differed markedly in weight gain from females which were perinatally androgenized and ovariectomized at weaning. The effects of androgenization and ovariectomy on weight gain were comparable and additive in female rats fed restrictedly or ad libitum. Nevertheless, androgenized + ovariectomized female rats fed restrictedly or ad libitum failed to grow as rapidly as male rats. Some additional factor(s) prevents complete masculinization of the female pattern of development. The stimulatory effects of androgenization and ovariectomy on the growth of females appear to be related to endocrine mechanisms controlling the onset of pubertal changes in somatic development.
Program slicing for codesign (2002)

Program slicing is a software analysis technique that computes the set of operations in a program that may affect the computation at a particular operation. Interprocedural slicing techniques have separately addressed concurrent programs and hardware description languages. However, application of slicing to codesign of embedded systems requires dependence analysis across the hardware-software interface.We extend program slicing for a codesign environment. Hardware-software interactions common in component-based systems are mapped to previously introduced dependences, including the interference and signal dependences. We introduce a novel access dependence that models a memory access side effect that results in activation of a process. A slicing algorithm that incorporates this variety of dependences is described.
Acoustic attenuation, phase and group velocities in liquid-filled pipes: Theory, experiment, and examples of water and mercury (2010)

Del Grosso's [Acustica 24, 299-311 (1971)] formulation, which predicts the phase speed of propagating axisymmetric modes inside a liquid-filled tube, is here extended to the complex domain in order to predict the attenuation, as well as the sound speed, of the modes as a function of frequency. Measurements of the sound speeds and the attenuations of the modes were performed in a water-filled Poly (methyl methacrylate) (PMMA) tube of internal radius, b=4.445 cm, in the range of the wavenumber-radius product, k(1)b, from 2 to 10. Parts of three or four modes were investigated and the measured sound speeds and the damping of the modes were compared with the theoretical predictions. The theory was then used to estimate the modal sound speeds and attenuations in a stainless-steel pipe filled with mercury having the same dimensions as are used in the Spallation Neutron Source at Oak Ridge National Laboratory, Tennessee.
Validation of a fault-tolerant clock synchronization system (1984)

A validation method for the synchronization subsystem of a fault tolerant computer system is investigated. The method combines formal design verification with experimental testing. The design proof reduces the correctness of the clock synchronization system to the correctness of a set of axioms which are experimentally validated. Since the reliability requirements are often extreme, requiring the estimation of extremely large quantiles, an asymptotic approach to estimation in the tail of a distribution is employed.
Modelling the extreme hydrological event of Summer 2007 in the Severn Uplands from gauge and radar rainfall sources (2009)

This paper provides a comparison of gauge interpolated and radar derived precipitation data sources for an upland<br/>catchment in the UK for a time period when extreme hydrological conditions were prevalent. Subsequently,<br/>a performance measure was used to evaluate the accuracy of hydrological simulation of extreme conditions using<br/>the two independent precipitation data sources within a HEC-HMS modelling framework. Discrepancies between<br/>gauge and radar time-series precipitation records were found to coincide with elevation, spatial distribution<br/>of precipitation and distance from the radar source. The Nash-Sutcliffe performance measure indicated that<br/>despite the higher temporal and spatial resolution of the radar data, interpolated gauging station records produced<br/>comparative accuracy when replicating the extreme hydrological event of Summer 2007
Radio-frequency hazards in the VLF to MF band (1982)

The body currents induced in a human in conductive contact with various ungrounded metallic objects like cars, trucks, fences, etc., are calculated for the frequency band 10 kHz to 10 MHz. The calculated incident E-fields required to produce thershold perception and let-go currents indicate that the recently proposed ANSI guideline of 100 mW/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (∼615 V/m) in the frequency band 0.3 to 3.0 MHz may result in a potential for RF burns.
Functional role of internal water molecules in rhodopsin revealed by x-ray crystallography (2002)

Activation of G protein-coupled receptors (GPCRs) is triggered and regulated by structural rearrangement of the transmembrane heptahelical bundle containing a number of highly conserved residues. In rhodopsin, a prototypical GPCR, the helical bundle accommodates an intrinsic inverse-agonist 11-cis-retinal, which undergoes photo-isomerization to the all-trans form upon light absorption. Such a trigger by the chromophore corresponds to binding of a diffusible ligand to other GPCRs. Here we have explored the functional role of water molecules in the transmembrane region of bovine rhodopsin by using x-ray diffraction to 2.6 A. The structural model suggests that water molecules, which were observed in the vicinity of highly conserved residues and in the retinal pocket, regulate the activity of rhodopsin-like GPCRs and spectral tuning in visual pigments, respectively. To confirm the physiological relevance of the structural findings, we conducted single-crystal microspectrophotometry on rhodopsin packed in our three-dimensional crystals and show that its spectroscopic properties are similar to those previously found by using bovine rhodopsin in suspension or membrane environment.
Draft Genome Sequence of Alicyclobacillus hesperidum Strain URH17-3-68 (2012)

Alicyclobacillus hesperidum is a thermoacidophilic bacterium. We isolated strain URH17-3-68 from hot spring sludge in Tengchong, Yunnan province, China. Its extracellular products include heat- and acid-stable enzymes which are important for industrial applications. Here we report the draft genome of this strain.
Mutual influences of pain and emotional face processing (2014)

The perception of unpleasant stimuli enhances whereas the perception of pleasant stimuli decreases pain perception. In contrast, the effects of pain on the processing of emotional stimuli are much less known. Especially given the recent interest in facial expressions of pain as a special category of emotional stimuli, a main topic in this research line is the mutual influence of pain and facial expression processing. Therefore, in this mini-review we selectively summarize research on the effects of emotional stimuli on pain, but more extensively turn to the opposite direction namely how pain influences concurrent processing of affective stimuli such as facial expressions. Based on the motivational priming theory one may hypothesize that the perception of pain enhances the processing of unpleasant stimuli and decreases the processing of pleasant stimuli. This review reveals that the literature is only partly consistent with this assumption: pain reduces the processing of pleasant pictures and happy facial expressions, but does not - or only partly - affect processing of unpleasant pictures. However, it was demonstrated that pain selectively enhances the processing of facial expressions if these are pain-related (i.e., facial expressions of pain). Extending a mere affective modulation theory, the latter results suggest pain-specific effects which may be explained by the perception-action model of empathy. Together, these results underscore the important mutual influence of pain and emotional face processing.
The tetrahedral intermediate from the hydration of <i>N</i>-methylformanilide (1993)

Heats of hydrolysis of N-methylformanilide dimethyl acetal have been measured in basic solution. The heat of formation of N-methylformanilide was obtained by determining the equilibrium constant in aqueous solution for its formation from formic acid and N-methylaniline as a function of temperature:[Formula: see text]. These data permit the calculation of the heat of formation of N-methylformanilide dimethyl acetal, [Formula: see text]. The free energy of formation of the tetrahedral intermediate in the hydrolysis of N-methylformanilide was calculated by methods we have previously reported. Consideration of the energetics of the intermediates and the known rates of reaction leads to the conclusion that the rate-determining step for alkaline hydrolysis is cleavage of the C—N bond.
A Probabilistic Algorithm for Multi-aircraft Collision Detection and Resolution in 3-D (2008)

This paper presents a real-time algorithm for collision detection, collision avoidance and guidance. Three-dimensional point-mass aircraft models are used. For collision detection, conflict probability is calculated by using the Monte-Carlo Simulation. Time at the closest point of approach(CPA) and distance at CPA are needed to determine the collision probability, being compared to certain threshold values. For collision avoidance, one of possible maneuver options is chosen to minimize the collision probability. For guidance to a designated way-point, proportional navigation guidance law is used. Two scenarios on encounter situation are studied to demonstrate the performance of proposed algorithm.
Clinical Pharmacology of Caffeine (1990)

Caffeine is the most widely consumed stimulant drug in the world. This chapter reviews the human pharmacology of caffeine; the evidence for its role in causing human disease, including addiction; and its potential usefulness as a therapeutic agent.
Lamivudine and Glycyrrhizin for Treatment of Chemotherapy-Induced Hepatitis B Virus (HBV) Hepatitis in a Chronic HBV Carrier with Non-Hodgkin Lymphoma (2001)

We report a chronic hepatitis B virus (HBV) carrier with non-Hodgkin lymphoma (NHL) who developed HBV hepatitis following conventional dose chemotherapy and was successfully treated with lamivudine and glycyrrhizin. A 55 year-old male patient with primary testicular NHL (diffuse large B-cell type) relapsed. During the salvage chemotherapy, the patient showed elevated serum levels of transaminase and HBV-DNA due to HBV reactivation. Treatment with lamivudine, an antiviral nucleoside analog, was started at a dose of 100mg/day. Shortly after the treatment the HBV-DNA level was suppressed, and sustained elevation of transaminase levels were normalized after additional treatment with glycyrrhizin. This experience suggests that lamivudine combined with glycyrrhizin may be effective for controlling HBV replication and treating chemotherapy-induced HBV hepatitis in chronic HBV carriers with NHL.
Regulation of water, salinity, and cold stress responses by salicylic acid (2014)

Salicylic acid (SA) is a naturally occurring phenolic compound. SA plays an important role in the regulation of plant growth, development, ripening, and defense responses. The role of SA in the plant-pathogen relationship has been extensively investigated. In addition to defense responses, SA plays an important role in the response to abiotic stresses, including drought, low temperature, and salinity stresses. It has been suggested that SA has great agronomic potential to improve the stress tolerance of agriculturally important crops. However, the utility of SA is dependent on the concentration of the applied SA, the mode of application, and the state of the plants (e.g., developmental stage and acclimation). Generally, low concentrations of applied SA alleviate the sensitivity to abiotic stresses, and high concentrations of applied induce high levels of oxidative stress, leading to a decreased tolerance to abiotic stresses. In this article, the effects of SA on the water stress responses and regulation of stomatal closure are reviewed.