gebhart/patrepeval huggingface dataset:
Binding of Upstream Stimulatory Factor and a Cell-specific Activator to the Calcitonin/Calcitonin Gene-related Peptide Enhancer (1997)

The calcitonin/calcitonin gene-related peptide (CT/CGRP) gene is selectively transcribed in thyroid C cells and neurons. We have previously shown that the rat CT/CGRP cell-specific enhancer is synergistically regulated by a helix-loop-helix (HLH) protein and the OB2 octamer-binding protein. In this report, we show that the HLH-OB2 enhancer is required for full promoter activity, even in the context of other HLH elements. Since this enhancer appears to be a major controlling element, we have characterized the HLH and OB2 DNA binding proteins. We have identified the major HLH complex as a heterodimer of the ubiquitous upstream stimulatory factor (USF)-1 and USF-2 proteins. USF bound the enhancer with a reasonably high affinity (KD 1.6 nM), comparable to other genes. Characterization of a series of mutations revealed that a portion of the HLH motif is also recognized by OB2 and confirmed that HLH activity requires OB2. We have shown that OB2 is a single DNA binding protein based on UV cross-linking studies. The 68-kDa protein-DNA complex was detected only in C cell lines, including a human C cell line that has robust HLH-OB2 enhancer activity. These results suggest that the calcitonin/CGRP gene is controlled by the combinatorial activity of a ubiquitous USF HLH heterodimer and an associated cell-specific activator.
Components of Podophyllin. XIX.<sup>2</sup> Isomorphism in the Podophyllotoxin Series (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComponents of Podophyllin. XIX.2 Isomorphism in the Podophyllotoxin SeriesANTHONY W. SCHRECKER, MARY M. TRAIL, and JONATHAN L. HARTWELLCite this: J. Org. Chem. 1956, 21, 3, 292–294Publication Date (Print):March 1, 1956Publication History Published online1 May 2002Published inissue 1 March 1956https://doi.org/10.1021/jo01109a009RIGHTS & PERMISSIONSArticle Views41Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (295 KB) Get e-Alerts Get e-Alerts
Novel Therapeutics for Schizophrenia: <i>Targeting Glycine Modulation of NMDA Glutamate Receptors</i> (2007)

Currently, a major hypothesis for the pathophysiology of schizophrenia proposes that numerous risk factors converge on the N -methyl-D-aspartate (NMDA) receptor for the neurotransmitter glutamate, resulting in neurodevelopmental abnormalities at glutamate synapses and hypofunction of NMDA receptors.This hypothesis was presented in a previous “Trends in Psychopharmacology” column. Novel treatments are now in development that can theoretically boost the function of NMDA receptors by enhancing actions at the glycine co-transmitter site of this receptor complex. Early studies already indicate that this may lead to improvement in negative and cognitive symptoms of schizophrenia, especially when added as augmenting agents to atypical antipsychotics.
Composite avalanche diode structures for increased power capability (1967)

The possibility of operating several avalanche oscillator wafers in parallel to obtain higher power and/or higher efficiency CW operation is explored analytically and experimentally. Experiments show that over a wide range the efficiency is roughly proportional to the power density in the semiconductor. The power densities required for good efficiency are very high and cannot be achieved in large area junctions without an excessive temperature rise caused by the thermal spreading resistance of the heat-sink material. The scheme delineated herein considers small area wafers spaced sufficiently close electrically that they operate as a single avalanche oscillator whereas their physical separation permits essentially independent heat sinking. It has been found that, as expected, the efficiency for CW operation improves approximately inversely with the diode diameter whereas the power capability for a given size wafer increases directly with the number of such wafers employed. The relative merits of mounting diodes on copper and on diamond are discussed. Experimental work indicates that the present approach is capable of producing 10 to 15 watts CW at 14 GHz in a single oscillator with available silicon diodes.
Fabrication of low cost soft tissue prostheses with the desktop 3D printer (2014)

Soft tissue prostheses such as artificial ear, eye and nose are widely used in the maxillofacial rehabilitation. In this report we demonstrate how to fabricate soft prostheses mold with a low cost desktop 3D printer. The fabrication method used is referred to as Scanning Printing Polishing Casting (SPPC). Firstly the anatomy is scanned with a 3D scanner, then a tissue casting mold is designed on computer and printed with a desktop 3D printer. Subsequently, a chemical polishing method is used to polish the casting mold by removing the staircase effect and acquiring a smooth surface. Finally, the last step is to cast medical grade silicone into the mold. After the silicone is cured, the fine soft prostheses can be removed from the mold. Utilizing the SPPC method, soft prostheses with smooth surface and complicated structure can be fabricated at a low cost. Accordingly, the total cost of fabricating ear prosthesis is about $30, which is much lower than the current soft prostheses fabrication methods.
Remote access tool for Earth science data (2002)

Presents an HTTP-based client/server application prototype that facilitates Internet access to Earth science data. The client consists of a Java applet GUI that allows the user to select spatial/temporal subsets of indexed datasets. The client also includes a MATLAB interface that allows the incoming data to be loaded directly into a MATLAB session. The server provides directory, catalog and data access services and performs the subsetting operations prior to data transmission. An example is presented where data from multiple sources and in multiple formats are combined into a single MATLAB plot. The prototype addresses the lack of common data models in the Earth sciences. It also addresses the need for access to corroborating data by Earth Observation Satellite (EOS) instrument team members for calibration and validation.
Particle collection characteristics of a single-stage dichotomous sampler (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTParticle collection characteristics of a single-stage dichotomous samplerAndrew R. McFarland, Carlos A. Ortiz, and Russell W. Bertch Jr.Cite this: Environ. Sci. Technol. 1978, 12, 6, 679–682Publication Date (Print):June 1, 1978Publication History Published online1 May 2002Published inissue 1 June 1978https://pubs.acs.org/doi/10.1021/es60142a006https://doi.org/10.1021/es60142a006research-articleACS PublicationsRequest reuse permissionsArticle Views162Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electron-diffraction transistors (2003)

The design, fabrication, and applications of QUADFETs (quantum diffraction field effect transistors) are described. The QUADFETs will enable Fraunhofer diffraction to be demonstrated and exploited. These devices are high-electron-mobility transistors (HEMTs), in which the source and a specially formed drain perform the functions of the light source and viewing screen of an analogous optical system, respectively. Experimental results on QUADFETs are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The EMI suppression of Ultra Thin MEMS microphone package (2010)

In this paper, we propose an Ultra Thin Flip-chip Package (UTFP) for MEMS microphone. We analyzed the electromagnetic interference (EMI) noise on the signal trace and E-field strength distribution in the package. To achieve the EMI suppression of MEMS microphone packages, we increased the quantity of the micro bumps, added the ground via in the substrate, and applied the metal coating around the acoustic port. The results show that the metal-coating acoustic port will increase EMI suppression by 14dB.
Flow cytometric kinetic measurements of neutrophil phospholipase A activation. (1992)

The interrelationships between activation of phospholipases and neutrophil stimulus-induced Ca2+ responses remain unclear. We report here that immune complexes activate a phosphatidylcholine-specific phospholipase A in a neutrophil only after the cytoplasmic Ca2+ transient has been initiated in the same cell, while chemotactic peptide activation does not proceed via such a phospholipase A-mediated mechanism. Measurements of [Ca2+] changes and of phosphatidylcholine-specific phospholipase A activity were made by flow cytometry, using Indo-1 for Ca2+ indication, and a new fluorescent probe, bis-BODIPY-phosphatidylcholine, localized in the inner leaflet of the plasma membrane, to measure phospholipase A activation. Both 100 nM formyl-methionyl-leucyl-phenylalanine (with or without cytochalasin B) and 60 micrograms/ml insoluble immune complexes elicited cytoplasmic Ca2+ transients, but only insoluble immune complexes stimulated phospholipase A activation in a subpopulation of cells exhibiting an elevation of [Ca2+]in. Phospholipase A activation followed the Ca2+ transient, starting, in each cell, after [Ca2+]in had begun to decrease as Ca2+ redistributed in the activated cell. The products of this phospholipase activation were confirmed by thin layer chromatography. We conclude that neutrophils respond to immune complexes with an elevated cytoplasmic Ca(2+)-requiring phosphatidylcholine-specific phospholipase A activation and to chemotactic peptides by a different mechanism.
The cylinder switch: an architecture for a manageable VLSI giga-cell switch (1990)

A cell switch architecture is proposed that provides resource allocation and buffer management features in the hardware. The cylinder switch system is specifically designed to take advantage of the properties of VLSI, and high-performance structures only available in VLSI can naturally be applied. The switch fabric is constructed from ring buffer/multiplexer VLSI modules that form a cylinder buffer. The buffers of this system are completely shared among the input channels. Multicasting, slot reservation in the buffer and on the output channel, class and priority control, and packet reordering are some of the feature that can be utilized. Both analog and digital observation and control can be utilized. The switch capacity using current VLSI technology could be in the tens of gigabits for a 100*100-channel switch. In addition to analytical and simulation studies, a prototype VLSI chip is being implemented for testing the ideas.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Introduction (2017)

This introduction presents an overview of the key concepts covered in the subsequent chapters of this book. The book introduces the early framing theories of critical accounting. It documents how researchers have borrowed from the interpretivist tradition to fashion a social scientific paradigm for subsequent accounting research endeavours. The book then identifies the role that Critical Theory has played in shaping critical accounting research from the 1980s through until the present day. It also provides a wide-ranging introduction to the substantial impact that the work of Foucault has had on critical accounting research during the past 30 years. The book documents some of the negativities that have resulted from an increasing process of colonisation by accounting thinking, particularly in the context of public sector organisations. It then provides an explanation of the relatively limited progress that has been made in respect of the travel of critical perspective–informed research from accounting to its near neighbour finance.
Hypoxia-induced enrichment and mutagenesis of cells that have lost DNA mismatch repair. (2001)

Loss of DNA mismatch repair (MMR) increases the risk of spontaneous mutations. We sought to determine whether there was an interaction between hypoxia and MMR deficiency that might contribute to the phenomenon of tumor progression. Human colon carcinoma HCT116+ch2 (MMR-deficient) and HCT116+ch3 (MMR-proficient) sublines were exposed for varying periods of time to an environment of <0.1% O2 and pH as low as 6.1. When a population containing 5% MMR-deficient cells and 95% MMR-proficient cells was subjected to hypoxia for 72 h, the MMR-deficient cells were enriched by a factor of 2-fold in the surviving population, whereas no enrichment was detected in cells maintained under aerobic conditions. The potential of hypoxia to destabilize the genome was determined by measuring the frequency of clones in the surviving population resistant to very high concentrations of 6-thioguanine or cisplatin. A 72-h exposure to hypoxia did not increase the frequency of resistant clones in the MMR-proficient cells but produced a 7.8-fold increase in 6-thioguanine-resistant clones and a 2.5-fold increase in cisplatin-resistant clones in the MMR-deficient cells. Loss of MMR increased the frequency of mutations in a reporter vector sensitive to frameshift mutations in a microsatellite sequence. Exposure to hypoxia for a time period as short as 48 h further increased the number of mutations in both cell types, but the absolute number of mutants was higher in the MMR-deficient cells. These results indicate that hypoxia and its accompanying low pH enrich for MMR-deficient cells and that loss of MMR renders human colon carcinoma cells hypersensitive to the ability of hypoxia to induce microsatellite instability and generate highly drug-resistant clones in the surviving population.
Boundary conditions for Young-van Vliet recursive filtering (2006)

Young and van Vliet have designed computationally efficient methods for approximating Gaussian-based convolutions by running a recursive infinite-impulse-response (IIR) filter forward over the input signal, then running a second IIR filter backward over the first filter's output. To transition between the two filters, they use a suboptimal heuristic that produces significant amplitude and phase distortion for all points within about three standard deviations of the right-hand boundary. In this correspondence, a simple linear transition rule that eliminates this distortion is derived.
THE CASE AGAINST HEPATIC ARTERY LIGATION IN PORTAL HYPERTENSION (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Towards a Technoeconomic Framework for Estimating Cost-Performance Tradeoffs for Power Plants Incorporating Transformative Dry-Cooling Technologies (2016)

Fresh water withdrawal for thermoelectric power generation in the U.S. is approximately 139 billion gallons per day (BGD), or 41% of total fresh water draw, making it the largest single use of fresh water in the U.S. Of the fresh water withdrawn for the power generation sector, 4.3 BGD is dissipated to the atmosphere by cooling towers and spray ponds. Dry-cooled power plants are attractive and sometimes necessary because they avoid significant withdrawal and consumption of freshwater resources that could otherwise be used for other purposes. This could become even more important when considering the potential effects of climate change (1). Additional benefits of dry-cooling include power plant site flexibility, reduced risk of water scarcity, and faster permitting (reducing project development time and cost). However, dry-cooling systems are known to be more costly and larger than their wet-cooling counterparts. Additionally, without the benefit of additional latent heat transfer through evaporation, the Rankine cycle condensing (cold) temperature for dry-cooling is typically higher than that for wet-cooling, affecting the efficiency of power production and the resultant levelized cost of electricity (LCOE). The Advanced Research Projects Agency - Energy (ARPA-E) has developed a technoeconomic analysis (TEA) model for the development of indirect dry-cooling systems employing steam condensation within a natural gas combined cycle power plant. The TEA model has been used to inform the Advanced Research in Dry-Cooling (ARID) Program on the performance metrics needed to achieve an economical dry-cooling technology. In order to assess the relationship between air-cooled heat exchanger (ACHX) performance, including air side heat transfer coefficient and pressure drop, and power plant economics, ARPA-E has employed a modified version of the National Energy Technology Laboratory (NETL) model of a 550 MW natural gas combined cycle (NGCC) plant employing an evaporative cooling system. The evaporative cooling system, including associated balance of system costs, was replaced with a thermodynamic model for an ACHX with the desired improved heat transfer performance and supplemental cooling and storage systems. Monte Carlo simulation determined an optimal ACHX geometry and associated ACHX cost. Allowing for an increase in LCOE of 5%, the maximum allowable additional cost of the supplemental cooling system was determined as a function of the degree of cooling of the working fluid required. This paper describes the methodologies employed in the TEA, details the results, and includes related models as supplemental material, while providing insight on how the open source tool might be used for thermal management innovation.
Clinical and Biological Significance of Vascular Endothelial Growth Factor in Endometrial Cancer (2007)

Increased levels of VEGF and angiogenic markers are associated with poor outcome in endometrioid endometrial cancer patients. Using a novel orthotopic model of endometrioid endometrial cancer, we showed that combination of antivascular therapy with docetaxel is highly efficacious and should be considered for future clinical trials.
Over-Constrained Scheduling using Dynamic Programming (1996)

In this paper, we demonstrate the use of stochastic dynamic programming to solve over-constrained scheduling problems. In particular, we propose a decision method for efficiently calculating, prior to start of execution, the optimal decision for every possible situation encountered in sequential, predictable, overconstrained scheduling domains. We present our results using an example problem from Product Quality Planning. Introduction In this paper, we demonstrate the use of stochastic dynamic programming to solve over-constrained scheduling problems. In particular, we propose a decision method for efficiently calculating, prior to start of execution, the optimal decision for every possible situation encountered in sequential, predictable, overconstrained scheduling domains. Over-constrained scheduling is a problem frequently encountered in the manufacturing industry. The general situation can be described as having a timeconstrained goal that requires the execution of a set...
Autoconfiguration of network services in airborne wireless networks (2005)

In this paper we consider the problem of autoconfiguring nodes in an airborne wireless network. The airborne platforms consist of routers as well as one or more hosts. External links from the airborne platform employ directional transmit beams. We expect the nodes to join or leave the network without pre-planning or manual configuration. Additionally we expect the users and applications of this network to discover available services in an automated manner. In this paper we present protocols that allow autoconfiguration of IPv6 addresses and names, as well as the automated discovery of services within the airborne wireless network.
Modulatory Effect of Dopamine on High‐Affinity Glutamate Uptake in the Rat Striatum (1987)

In vivo electrical stimulation of the frontal cortical areas was found to enhance sodium-dependent high-affinity glutamate uptake (HAGU) measured in rat striatal homogenates. This activating effect was counteracted by in vivo administration of apomorphine and by in vitro addition of dopamine (DA; 10(-8) M) in the incubation medium, and potentiated by in vivo haloperidol administration. At the doses used, the dopaminergic compounds had no effect on basal HAGU. alpha-Methylparatyrosine pretreatment was found to enhance slightly basal HAGU as well as the activating effects of cortical stimulation. Interestingly enough, lesion of dopaminergic neurons by substantia nigra injection of 6-hydroxydopamine (6-OHDA) did not cause any significant change either in basal HAGU or in the effect of cortical stimulation. Measurement of DA effects in vitro in experiments combined with in vivo manipulations of the dopaminergic nigrostriatal and corticostriatal systems showed that the capacity of DA to inhibit striatal HAGU depends directly on the level of the uptake activation reached over basal value. These results suggest that under physiological conditions, the dopaminergic nigrostriatal pathway exerts a modulatory presynaptic action on corticostriatal glutamatergic transmission, counteracting increasing glutamatergic activity. In the case of chronic DA depletion induced by 6-OHDA, striatal adaptations may occur modifying the mechanisms acting at corticostriatal nerve terminal level.