gebhart/patrepeval huggingface dataset:
Pyrimidine-2,4,6-Triones: A New Effective and Selective Class of Matrix Metalloproteinase Inhibitors (2001)

Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that have been implicated in various disease processes. Different classes of MMP inhibitors, including hydroxamic acids, phosphinic acids and thiols, have been previously described. Most of these mimic peptides and most likely bind in a similar way to the corresponding peptide substrates. Here we describe pyrimidine-triones as a completely new class of metalloprotease inhibitors. While the pyrimidine-trione template is used as the zinc-chelating moiety, the substituents have been optimized to yield inhibitors comparable in their inhibition efficiency of matrix metalloproteinases to hydroxamic acid derivatives such as batimastat. However, they are much more specific for a small subgroup of MMPs, namely the gelatinases (MMP-2 and MMP-9).
Fabrication of microlens arrays by gel trapping of self-assembled particle monolayers at the decane–water interface (2004)

A new technique for producing ordered microlens arrays has been developed which is based entirely on self-assembly of charged latex particles spread at an oil–water interface. It includes using a gel trapping technique and replication of the ordered particle monolayers by casting with PDMS. Microlens arrays were fabricated by taking an inverse replica of the PDMS template with a photopolymer.
Germ cell nuclei of male fetal mice can support development of chimeras to midgestation following serial transplantation (1995)

Chimeric embryos between fertilized eggs from F1 (C57BL x CBA) and 15.5-16.5 days post coitum (dpc) male fetal germ cells (FGCs) from CD-1 strain (glucose phosphate isomerase, Gpi-1a/a) mice were produced by nuclear transfer. Briefly, a single FGC was fused with enucleated oocytes and activated, and the reconstituted oocytes were cultured to the 2-cell stage. The nucleus from the reconstituted 2-cell embryos was then transferred into an enucleated blastomere of the same stage embryos derived from F1 mice to produce chimeric embryos. The reconstituted 2-cell embryos, which synchronously divided to the 4-cell stage after treatment with nocodazole, were further cultured in vitro. Compacted morula and blastocysts were transferred to the uteri of pseudopregnant female mice. Some recipients were allowed to develop to term and the others were killed at mid gestation to analyze the contribution of donor FGC-derived cells. Survival to term was low with no chimeric animals. Glucose phosphate isomerase (GPI) analysis at midgestation revealed that some conceptuses had chimerism in the fetuses, trophoblast and yolk sac at day 10.5 of pregnancy. The contribution of donor cells was 37-47%, 19-65% and 12-63%, respectively. It was concluded that the nucleus from 15.5-16.5 dpc male fetal germ cells had the potency to develop into fetus, trophoblast and yolk sac after serial nuclear transfer with oocytes and fertilized embryos. The reason for the low viability of chimeric embryos is discussed.
[The analysis of T cell receptor Vbeta gene usage of cytolytic T-lymphocytes in coxsackievirus B3-induced myocarditis]. (2006)

The TCR Vbeta gene usage of CTLs which result in immune-mediated myocyte injury in Coxsackievirus B3-induced myocarditis is markedly restricted in cells stimulated by specific antigen.
No enlargement of the right internal jugular vein of the dialysis patients in the Trendelenburg position (2013)

In contrast to healthy volunteers, there was no enlargement of the RIJV when dialysis patients were in the Trendelenburg position. The reason for this phenomenon may be multifactorial, with diastolic dysfunction being the most likely cause, and further investigation is required to clarify the cause. Our investigation suggests that the supine position for central venous catheterization in dialysis patients is superior to the Trendelenburg position.
The Links between Transcription, β-catenin/JNK Signaling, and Carcinogenesis (2009)

Interactions between transcription and signaling are fundamentally important for understanding both the structure and function of genetic pathways and their role in diseases such as cancer. The finding that beta-catenin/TCF4 and JNK/c-Jun cooperate has important implications in carcinogenesis. Previously, we found that binding of c-Jun and beta-catenin/TCF4 to the c-jun promoter is dependent upon JNK activity, thus one role for this complex is to contribute to the repression and/or activation of genes that may mediate cell maintenance, proliferation, differentiation, and death, whereas deregulation of these signals may contribute to carcinogenesis. Here we address the functional links reported between activated beta-catenin/JNK signaling pathways, their component genes, and their common targets, and discuss how alterations in the properties of these genes lead to the development of cancer.
Discriminant and Cluster Analysis as Statistical Aids in Stratigraphic Correlation: ABSTRACT (1982)

Stratigraphic interpretation has largely been done by geological, geophysical, and well-logging techniques. Statistical analysis of geophysical and well-logging data has been rather well accepted during the past 10 to 20 years. Analysis of geochemical data has only been recently accepted as a technique that aids in correlation and interpretation of other stratigraphic problems. Two statistical techniques which have proven useful in stratigraphic or other types of geological interpretation have been cluster and discriminant analysis. These techniques are generally regarded as investigative tools. However, they can also be used in a predictive sense. This is particularly true of discriminant analysis. In both techniques, one allows the observed data to describe the similarity of formations, produced fluids, or some other measure of interest. These statistical methods have been applied using oil or water chemistry, well-logging data, and various reservoir parameters to solve stratigraphic problems or support a hypothesis. These techniques have been used successfully to recognize bypassed oil, sedimentary environments of deposition, miscorrelated horizons, and e roneous data. In this paper, several case studies are presented that involve cluster and discriminant analysis to establish or substantiate hypotheses about reservoir continuity. These include one North Sea field, one Middle East field, and one domestic reservoir. A model which was previously proposed is further extended; this model will distinguish whether a produced water has been in contact with either oil or gas. These techniques can be advantageous in planning future exploration strategy. End_of_Article - Last_Page 581------------
Crashworthiness evaluation of composite vehicle side door (2014)

This paper intends to address the crashworthiness, design aspects, and method of analysis with particular reference to the application of composite materials to automotive front door design. The current material solution, steel solution, has been substituted by chosen composite materials on the bases of equal thickness and equal stiffness criteria. Major constraints are dealt with crash resistance and stiffness of door panels and impact beam against side crash, according to exist standards. Finally, the results predicted by the finite element analysis are evaluated and interpreted on the bases of crashworthiness and method of production to insight the effectiveness of the proposed solution. The results revealed that composite door could be better for absorbing energy during the side crash impact if it is designed properly
Effect of Delamination on Moisture Accelerated Failures in Plastic Encapsulated Microcircuits (1997)

This paper presents a study to determine the extent to which delamination at the die to encapsulant interface affects the package moisture content, and electrical failures when subjected to unbiased temperature‐humidity testing. Moisture absorption experiments showed that the presence of delamination did not significantly after the measurable moisture absorption characteristics of packages. Reliability testing indicated that although delamination is generally thought of as a reliability risk, it may not be a sufficient condition to promote damage in packages under dormant storage conditions. Experimental results showed no parametric or functional failures (or visible degradation) in packages with 100% die surface delamination after 1000 hours of unbiased testing at 140°C/85%RH.
RNA‐mediated neurodegeneration in repeat expansion disorders (2009)

Most neurodegenerative disorders are thought to result primarily from the accumulation of misfolded proteins, which interfere with protein homeostasis in neurons. For a subset of diseases, however, noncoding regions of RNAs assume a primary toxic gain-of-function, leading to degeneration in many tissues, including the nervous system. Here we review a series of proposed mechanisms by which noncoding repeat expansions give rise to nervous system degeneration and dysfunction. These mechanisms include transcriptional alterations and the generation of antisense transcripts, sequestration of mRNA-associated protein complexes that lead to aberrant mRNA splicing and processing, and alterations in cellular processes, including activation of abnormal signaling cascades and failure of protein quality control pathways. We place these potential mechanisms in the context of known RNA-mediated disorders, including the myotonic dystrophies and fragile X tremor ataxia syndrome, and discuss recent results suggesting that mRNA toxicity may also play a role in some presumably protein-mediated neurodegenerative disorders. Lastly, we comment on recent progress in therapeutic development for these RNA-dominant diseases.
Characterization of the ros1-gene products expressed in human glioblastoma cell lines. (1989)

Most glioblastoma-derived cell lines express an 8.3 kb ros1 transcript and a 280 kD glycoprotein designated gp280ros1, which can be specifically immunoprecipitated with an anti-ROS antibody. This 280 kD protein possesses in vitro autokinase activity and was observed in four independent glioblastoma cell lines. In a fifth glioblastoma cell line, U-118 MG, a smaller ros1 transcript of 4.0 kb was observed. Immunoprecipitation analysis reveals that the U-118 MG expressed a smaller, 116 kD ros1 gene product. cDNA cloning and sequencing of the U-118 MG ros1 transcript indicates it encodes the entire tyrosine kinase domain and two amino acids of the transmembrane domain of ros1 at its 3' end. Sequences at its 5' end likely arise from another gene.
MPEG++-a robust compression and transport system for digital HDTV (2003)

An overview is presented of the MPEG++ robust compression and transport algorithm used in ADTV (advanced digital television), a recently proposed simulcast digital HDTV (high-definition television) system. MPEG++ achieves robust delivery of compressed video through the addition of media-specific data prioritization and transport layers to a standard MPEG bit-stream. MPEG++ is described, with particular emphasis on video-specific transport features that have been added to mitigate the impact of channel errors. Simulation results using an MPEG++ software model are briefly discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Detailed analysis of secondary ions' effect for the calculation of neutron-induced SER in SRAMs (2001)

A new method of neutron soft error rate calculation derived from device simulations and nuclear physics results is presented. The main inputs are only a critical linear energy transfer, a critical charge, and layout dimensions. No classical sensitive volume size is needed because the extension of the sensitive region is described in terms of the variation of the ion efficacy versus its position with respect to the sensitive drain.
Analysis of Modified β-Lactoglobulins and Ovalbumins Prepared from the Sulfenyl Iodide Intermediates (1960)

In an earlier communication (l), we have described techniques and conditions under which iodine reacts rather specifically with the free sulfhydryl groups of proteins.The initial product of this reaction was presumed to be protein sulfenyl iodide groups.In this communication, we shall present further evidence to substantiate the view that sulfenyl iodide is a relatively stable intermediate in the oxidation of ovalbumin and fi-lactoglobulin with iodine, and describe several modified proteins which may be prepared through these sulfenyl iodide intermediates.EXPERIMENTAL
Chemistry and Pharmacology of Analgesic Indole Alkaloids from the Rubiaceous Plant, Mitragyna speciosa (2004)

The leaves of a tropical plant, Mitragyna speciosa KORTH (Rubiaceae), have been traditionally used as a substitute for opium. Phytochemical studies of the constituents of the plant growing in Thailand and Malaysia have led to the isolation of several 9-methoxy-Corynanthe-type monoterpenoid indole alkaloids, including new natural products. The structures of the new compounds were elucidated by spectroscopic and/or synthetic methods. The potent opioid agonistic activities of mitragynine, the major constituent of this plant, and its analogues were found in in vitro and in vivo experiments and the mechanisms underlying the analgesic activity were clarified. The essential structural features of mitragynines, which differ from those of morphine and are responsible for the analgesic activity, were elucidated by pharmacological evaluation of the natural and synthetic derivatives. Among the mitragynine derivatives, 7-hydroxymitragynine, a minor constituent of M. speciosa, was found to exhibit potent antinociceptive activity in mice.
Synthesis and Structural Characterization of Bis- and Tris(<i>closo</i>-1,2-C<sub>2</sub>B<sub>10</sub>H<sub>11</sub>-1-yl)-Substituted Biphenyl and Benzene (1996)

The synthesis and characterization of di-and tricarborane-substituted biphenyl and benzene derivatives are described. The direct reaction of aromatic alkyne with B10H12(Et2S)2 provides the title compounds in high yields. These molecules are a class of structurally important modular components for the construction of carborane-based supramolecular structures.
X-ray Photoelectron Spectroscopy Evidence for the Covalent Bond between an Iron Surface and Aryl Groups Attached by the Electrochemical Reduction of Diazonium Salts (2003)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTX-ray Photoelectron Spectroscopy Evidence for the Covalent Bond between an Iron Surface and Aryl Groups Attached by the Electrochemical Reduction of Diazonium SaltsKada Boukerma, Mohamed M. Chehimi, Jean Pinson, and Chris BlomfieldView Author Information Interfaces, Traitements, Organisation et Dynamique des Systèmes (ITODYS), Université Paris 7-Denis Diderot, associé au CNRS (UMR 7086), 1 rue Guy de la Brosse, F-75005 Paris, France, Laboratoire d'Electrochimie Moléculaire, Université Paris 7-Denis Diderot, Unité Mixte Université Paris 7-CNRS 7591, 2 Place Jussieu, 75251, Paris Cedex 05, France, and Kratos Analytical Limited, Wharfside, Trafford Wharf Road, Manchester M17 1GP, United Kingdom Cite this: Langmuir 2003, 19, 15, 6333–6335Publication Date (Web):June 26, 2003Publication History Received3 February 2003Revised16 May 2003Published online26 June 2003Published inissue 1 July 2003https://pubs.acs.org/doi/10.1021/la030046ghttps://doi.org/10.1021/la030046gbrief-reportACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views1346Altmetric-Citations157LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Iron,Layers,Oxides,Salts,X-ray photoelectron spectroscopy Get e-Alerts
Crystallization under Strain and Resultant Orientation of Poly(ε-caprolactone) in Miscible Blends (1999)

The crystallization of poly(ε-caprolactone) (PCL) in stretched miscible and amorphous blends containing 25−50 wt % of poly(vinyl chloride) (PVC) was monitored by infrared spectroscopy. It was found that, under most conditions, the crystallization under strain leads to a segmental crystalline orientation perpendicular to the strain direction, whereas a parallel crystalline chain orientation is observed under conditions where the crystallization is more rapid and the draw ratio higher. This orientation behavior was confirmed by X-ray diffraction measurements. The parallel orientation can be explained by an epitaxial growth of folded-chain lamellae from row nuclei. We suggest that the perpendicular orientation is mainly the result of the folding of oriented chains leading to lamellae aligned along the strain direction. Whatever the crystalline orientation direction, the crystallization of PCL under strain gives rise to nonspherulitic morphologies, different from those found when PCL is crystallized in unstretched blends. However, the magnitude of the resultant segmental orientation, both parallel and perpendicular, is similar to the orientation achieved by stretching crystalline PCL in the solid state at room temperature that is known to transform the spherulites into microfibrils.
Gel wax-based tissue-mimicking phantoms for multispectral photoacoustic imaging (2018)

Tissue-mimicking phantoms are widely used for the calibration, evaluation and standardisation of medical imaging systems, and for clinical training. For photoacoustic imaging, tissue-mimicking materials (TMMs) that have tuneable optical and acoustic properties, high stability, and mechanical robustness are highly desired. In this study, gel wax is introduced as a TMM that satisfies these criteria for developing photoacoustic imaging phantoms. The reduced scattering and optical absorption coefficients were independently tuned with the addition of TiO<sub>2</sub> and oil-based inks. The frequency-dependent acoustic attenuation obeyed a power law; for native gel wax, it varied from 0.71 dB/cm at 3 MHz to 9.93 dB/cm at 12 MHz. The chosen oil-based inks, which have different optical absorption spectra in the range of 400 to 900 nm, were found to have good photostability under pulsed illumination with photoacoustic excitation light. Optically heterogeneous phantoms that comprised of inclusions with different concentrations of carbon black and coloured inks were fabricated, and multispectral photoacoustic imaging was performed with an optical parametric oscillator and a planar Fabry-Pérot sensor. We conclude that gel wax is well suited as a TMM for multispectral photoacoustic imaging.
Consistent Replication of Multithreaded Distributed Objects (2006)

Determinism is mandatory for replicating distributed objects with strict consistency guarantees. Multithreaded execution of method invocations is a source of nondeterminism, but helps to improve performance and avoids deadlocks that nested invocations can cause in a single-threaded execution model. This paper contributes a novel algorithm for deterministic thread scheduling based on the interception of synchronisation statements. It assumes that shared data are protected by mutexes and client requests are sent to all replicas in total order; requests are executed concurrently as long as they do not issue potentially conflicting synchronisation operations. No additional communication is required for granting locks in a consistent order in all replicas. In addition to reentrant mutex locks, the algorithm supports condition variables and time-bounded wait operations. An experimental evaluation shows that, in some typical usage patterns of distributed objects, the algorithm is superior to other existing approaches
Effect of a prenylamine analog (MG8926) on spontaneous action potentials in isolated rabbit sinoatrial node. (1996)

Effects of verapamil, prenylamine and a prenylamine analog, MG8926 on the intracellular spontaneous action potentials recorded from the isolated rabbit sinoatrial (SA) node were studied. Verapamil (1 microM), a selective inhibitor for slow Ca2+ channels, prolonged the cycle length, decreased the rate of diastolic depolarization, the rate of rise of action potential, the amplitude of action potential and the maximal diastolic potential, and usually arrested showing subthreshold fluctuation of the membrane potential within several ten min. Prenylamine (10 microM), a nonselective inhibitor for slow Ca2+ channels, tended to prolong the cycle length to decrease the diastolic depolarization, the rate of rise of action potential, the amplitude of action potential. However, these changes were statistically insignificant. Prenylamine at the concentration of 10 microM had no effect on the maximal diastolic potential. MG8926 (10 microM) prolonged the cycle length, decreased the rate of diastolic depolarization, the rate of rise of action potential and tended to decrease the amplitude of action potential. MG8926 at the concentration of 10 microM had almost no effect on the maximal diastolic potential. The present findings may indicate that replacement of phenyl residue of prenylamine by cyclohexyl residue increases the inhibitory action on the slow Ca2+ channels in rabbit SA node.
The Properties of Cotton Reacted with β-Propiolactone (1956)

A number of the textile and chemical properties of cotton reacted with β-propiolactone have been investigated and are reported. Differences in the properties of the products of the reflux and of the alkali methods of treatment are shown. Reaction of cotton with β-propiolactone yields a cellulose derivative with a bound graft polymer. The results of this unusual reaction are shown by optical means with micro scopic cross sections and electron micrographs, by changes in X-ray diffraction patterns, by influence on textile properties, by chemical effects such as saponification to yield car boxyethylcellulose, and by the production of unsaturation in the cellulose derivative.