gebhart/patrepeval huggingface dataset:
Pituitary synaptic protein SNAP-25 sensitive to GnRH is necessary for LH release. (2004)

Our study showed that SNAP-25 is present in adenohypophyses in vitro as well as in vivo and that is involved in LH release and that GnRH can modify its expression.
Using a Transaction Definition Language for the Automated ARMing of Web Services (2002)

Web service technology will provide a platform for next generation dynamic e-business applications. This paper describes a framework for identifying, monitoring and reporting performance data of critical transactions within a web service using the Java ARM standard, a Transaction Definition Language (TDL) and an Automated Instrumentation technique. Gourmet2Go, a demonstrator provided with the IBM web services toolkit, is used as a case study.
Conformation and Microenvironment of the Active Site of Xylose Reductase Inferred by Fluorescent Chemoaffinity Labeling (1997)

Conformation and microenvironment at the active site of xylose reductase (XR) from Neurospora crassa was probed with fluorescent chemoaffinity labeling (FCAL) using o-phthalaldehyde as a chemical initiator. Formation of a single isoindole derivative resulted in complete inactivation of the enzyme as judged by spectroscopic and fluorescence studies. Kinetic analysis of the 2,4,6-trinitrobenzenesulfonic-acid-modified XR implicated the presence of an essential lysine residue at the active site of XR. Modification of lysine in XR abolished the ability of the enzyme to form isoindole derivative, indicating that the lysine residue involved in the reaction with 2,4,6-trinitrobenzenesulfonic acid and o-phthalaldehyde is the same and that the probe o-phthalaldehyde is directed to the active site. Fluorescence studies revealed that inactivation of XR by Gdn/HCl precedes gross conformational change and the possibility of secondary-conformational change was eliminated by acrylamide quenching studies. The enzyme inactivated by low concentrations of Gdn/HCl retained its ability to form the fluorescent XR-isoindole derivative indicating that inactivation is not due to conformational changes at or near the active site of XR. Gdn/HCl also had no effect on the high-affinity and low-affinity NADPH-binding sites of XR. Energy-transfer experiments further revealed structural integrity at the active site of the Gdn/HCl-inactivated XR. Changes in the fluorescence emission maximum of 1-(beta-hydroxyethylthio)-2-beta hydroxyethyl isoindole (EA adduct) in solvents of varying polarity was studied, the data obtained were utilized to interpret the fluorescence behaviour of XR-isoindole derivative and assess the polarity at the active site. Experimental evidence presented here serves to suggest that the inactivation of XR by Gdn/HCl precedes conformational changes at the active site located in a microenvironment of low polarity.
Reinforcement Learning for Tracking Control in Robotics (2015)

For a robot manipulator, an accurate reference tracking capability is one of the most important performance factor. This is especially the case for a robot which is deployed for an industrial use such as welding and laser cutting. Recently, an emerging application of 3D printing also attracts researchers to use robotic manipulators in hope of gaining a higher dimension in the printing process as well as a larger workspace. The conventional method for controlling robot manipulator involves a model based feed-forward controller to eliminate the nonlinearities such as gravity and the coriolis term, combined with a feedback controller to compensate the residual error. This method, however, has a drawback in obtaining a good model of the robot. Furthermore, a robot's physical properties are subject to change over time due to, for instance, degraded gearboxes, etc. Such a problem will require the robot to re-perform a system identification which is often unacceptable due to the time it takes and the possibly dangerous movement the robot must execute. Therefore, this class of controller may not be the best option for such condition. This thesis addresses the aforementioned problem from the point of view of model-free, learning controller which improves the tracking performance safely in an online fashion. The thesis exploits the reinforcement learning (RL) technique which uses the nature of trial and errors to correct the tracking error. Improvement to the control performance is done by feeding an additive compensation signal given by a learned policy function to the robot's nominal controller. Two different compensation methods are proposed in the thesis. Both methods are realized by the so called actor-critic (AC) algorithm in order to cope with the continuous state of a robot arm. The first method compensates the control input of the nominal controller while the second method modifies the reference trajectory. The methods are implemented on a real 6 DoFs 3D printing robotic setup. For the test, three different reference tracking tasks are designed and executed. Furthermore, to provide a comparative study, two conventional control methods namely model predictive control (MPC) and iterative learning control (ILC) are implemented as well. Their results are then analysed and compared to that of the proposed RL-based controllers. The experimental result shows that the RL-based controllers improve the performance of the nominal control significantly. It is also shown that the performance of the learning controller is close to that of the model-based control method. For a circular, smooth trajectory, the experiment even shows that the RL-based controller is able to outmatch both MPC and ILC performance.
Carbon Dioxide Formation From Organic Solutes in Aqueous Suspensions of Ultraviolet-Irradiated TiO2. Effect of Solute Concentration (1987)

The oxidation of a number of aromatic compounds to carbon dioxide by exposure to near U.V. light in aqueous titanium dioxide suspensions has been studied as a function of the solute concentration. In most, the dependence of the rate of CO2 formation follows the simple Langmuir expression: R(CO2)=k1k2[s]/(1+k1[s]) The rate is essentially independent of concentration above 200 µM and becomes progressively more dependent on the concentration as it decreases. Changes in the mineralization rate are most clearly reflected in k2, the parameter determined by the limiting rate at high concentrations. A consequence of the dependence is that total mineralization is strictly never achieved but is approached asymptotically at extended illumination times. The expression and parameters are given which enable the prediction of the extent of mineralization over a wide range of concentrations. The solutes studied were benzene, benzoic acid, benzoate ion, salicylate ion, phenol, chlorobenzene , aniline, anilinium ion, nitrobenzene, chloroform and formic acid. It was confirmed that pH and oxygen concentration affect the rate of carbon dioxide formation but, in the photochemical reactor used, the rate was not significantly affected by the amount of TiO2 suspended for loadings from 0.05 to 0.40 g per 400 ml.
Is This Headache Serious? (1997)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssueArchivesePub Ahead-of-Print Collections Acute/Critical CareArt of Nursing Back to BasicsCase ReportsContinuing EducationDisaster and Emergency PreparednessEnvironmental Health and IssuesEthics Evidence-Based Practice, Step by StepFamily CaregiversGeriatric NursingHolistic NursingIn The CommunityInfectious DiseaseInfluenza Classics from the AJN ArchivesInternational TopicsLegal ClinicMental HealthMilitary and Veterans Health Care New to NursingNursing Research, Step By StepNursing ResourcesPalliative CarePatient SafetyPatient Safety-Safety MonitorPolicy and PoliticsProfessional Development, Leadership and ScholarshipProfessional Partners Supporting Diverse Family Caregivers Across SettingsProfilesPutting Patients First – The Planetree CollectionQI: Quality ImprovementResearchSocial Media and Information TechnologySpecial SupplementsStrip SavvySupporting Family Caregivers: No Longer Home AloneSystematic Reviews Step by StepTeaching For PracticeTransforming Care at the Bedside (TCAB)Uniforms (Nursing)Uniting States, Sharing StrategiesWomen's HealthWriting Resources Multimedia PodcastsVideosHow to Try This VideosNew Look at the Old VideosSupporting Family CaregiversWebinars CE/NCPDFor Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor Permissions Journal Info About the JournalAdvertising and BusinessAJN Photo Exhibit: Faces of CaringAuthor Guidelines - ReflectionsAward WinnersBook of the Year AwardsContact InfoEditorial BoardInformation for FacultyInformation for MediaInformation for Peer ReviewersLetters to the EditorNurse Faculty Scholars / AJN Mentored Writing AwardOpen AccessReprintsRights and PermissionsSubscription ServicesNurses: Submit Your Photos! All Articles Images Videos Podcasts Blogs Advanced Search
Specific cleavage of peptides containing an aspartic acid (.beta.-hydroxamic acid) residue (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpecific cleavage of peptides containing an aspartic acid (.beta.-hydroxamic acid) residueJames K. Blodgett, G. Marc Loudon, and Kim D. CollinsCite this: J. Am. Chem. Soc. 1985, 107, 14, 4305–4313Publication Date (Print):July 1, 1985Publication History Published online1 May 2002Published inissue 1 July 1985https://pubs.acs.org/doi/10.1021/ja00300a039https://doi.org/10.1021/ja00300a039research-articleACS PublicationsRequest reuse permissionsArticle Views488Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Cognitive support for semi-automatic ontology mapping (2009)

Structured vocabularies are often used to annotate and classify data. These vocabularies represent a shared understanding about the terms used within a specific domain. People often rely on overlapping, but independently developed terminologies. This representational divergence becomes problematic when researchers wish to share, find, and compare their data with others. One approach to resolving this is to create a mapping across the vocabularies. Generating these mappings is a difficult, semi-automatic process, requiring human intervention. There has been little research investigating how to aid users with performing this task, despite the important role the user typically plays. Much of the research focus has been to explore techniques to automatically determine correspondences between terms. In this thesis, we explore the user-side of mapping, specifically investigating how to support the user’s decision making process and exploration of mappings. We combine data gathered from theories of human inference and decision making, an observational case study, online survey, and interview study to propose a cognitive support framework for ontology mapping. The framework describes the user information needs and the process users follow during mapping. We also propose a number of design principles, which help guide the development of an ontology mapping tool called COGZ. We evaluate the tool and thus implicitly the framework through a case study and controlled user study. The work presented in this thesis also helps to draw attention to the importance of the user role during the mapping process. We must incorporate a “human in the loop”, where the human is essential to the process of developing a mapping. Helping to establish and harness this symbiotic relationship between human processes and the tool’s automated process will allow people to work more efficiently and effectively, and afford them the time to concentrate on difficult tasks that are not easily automated.
Long-term tolerance of healthy human subjects to high amounts of xylitol and fructose: general and biochemical findings. (1976)

Random copolypeptides are promising and versatile bioinspired macromolecules of minimal complexity for studying their interactions with both living and synthetic matter. They provide the opportunity to investigate the role of, for example, total net charge and hydrophobicity through simply changing the monomer composition, without considering the effect of specific sequences or secondary structure. However, synthesizing large libraries of these polymers so far was prohibited by the time-consuming preparation methods available (ring-opening polymerization (ROP) of amino acid N-carboxyanhydrides and enzymatic polymerization of amino acids). Here we report the automated solid phase synthesis (SPS) of a complete library of polypeptides containing Glu, Lys, and Ala monomers with excellent control over the degree of polymerization and composition and with polydispersity indices (PDIs) between 1.01 and 1.001, which is impossible to achieve by other methods. This method provides access to a library of polymers with a precisely defined total charge that can range from approximately -15 to +15 per chain and with a disordered conformation almost completely devoid of any secondary structure. In solution the polymers are largely present as unimers, with only the most hydrophobic polypeptides showing slight signs of aggregation. Our new approach provides convenient access to libraries of this versatile class of polymers with tunable composition, which can be used in a wide variety of physicochemical studies as a tool that allows systematic variation of charge and hydrophobicity, without the interference of secondary structure or aggregation on their performance.
Depressed Interferon Gamma Production and Monocyte HLA-DR Expression After Severe Injury (1988)

Monocyte HLA-DR antigen expression and mitogen-stimulated interferon gamma production were measured sequentially on days 1, 3, 7, 14, and 21 after admission in 20 multiply injured patients (mean Injury Severity Score, 33). Ten patients recovered uneventfully and ten developed a major infection, three of whom died. Trauma resulted in immediate and profound depression of both interferon gamma production and monocyte HLA-DR antigen expression compared with controls. Interferon gamma remained below control levels for all days on which it was measured in all patients. In uninfected patients, interferon gamma production began to recover after day 7 and interferon gamma levels on day 21 were greater than on all other days. Monocyte HLA-DR antigen expression returned to normal between days 7 and 14 in uninfected patients, despite subnormal production of interferon gamma. Failure to increase interferon gamma production and monocyte HLA-DR antigen expression was associated with an episode of major infection. We postulate that stimulation of the immune system early after injury may reverse the defects reported and decrease the incidence of infection after severe trauma.
Characterization of the Fundal Reflectance of Infants (1991)

Pupillary images recorded by a linear knife-edge photoscreener for infants accommodating more or less within the bounds of chromatic aberration show three smooth offset pupillary irradiance ramps when analyzed with a color video camera and frame-grabbing hardware. Both the shape of the ramps and the lack of a second image in a shadowing experiment support the view that the retina acts as an angularly diffuse partial reflector in photorefraction. We propose a lateral image-spreading characteristic to account for observed color-dependent ramp heights and offsets and consider possible physical mechanisms for lateral spreading.
Evaluation of the impact of sodium lauryl sulfate source variability on solid oral dosage form development (2010)

The observed differences in wetting and solubilization were likely due to the different impurity levels in SLS from two sources. This study demonstrated that SLS from different sources could have significant impact on wet granulation process and dissolution. Therefore, it is critical to evaluate SLS properties from different suppliers, and then identify optimal formulation and process parameters to ensure robustness of drug product manufacture process and performance.
Motor Nerve Sprouting and Acetylcholine Receptors (1978)

Sprouting of motor nerve terminals was evoked by functional denervation of skeletal muscles brought about by presynaptic blockade or disuse. The amount of sprouting, determined by morphometric measurement, was correlated with the level of extrajunctional acetylcholine receptors. Sprouting was inhibited by blockade of acetylcholine receptors with alpha-bungarotoxin. Extrajunctional acetylcholine receptors may play an important role in eliciting motor nerve terminal sprouting.
No nukes is good news for supercomputers [nuclear weapons simulation] (1997)

By the year 2010, the Accelerated Strategic Computing Initiative will develop high performance, full-system high-fidelity predictive codes to support weapons design, production analysis, accident analysis, and certification. It will stimulate the US computer manufacturing industry to create the more powerful high-end supercomputing capability required by these applications and create a computational infrastructure and operating environment that makes these capabilities accessible and usable. The program has four main objectives: Performance-create predictive simulations of nuclear weapon systems to analyse behaviour and assess performance in an environment without nuclear testing; safety - predict with high certainty the behaviour of full weapons systems in complex accident scenarios; reliability - achieve sufficient, validated predictive capabilities to extend the lifetime of the stockpile, predict failure mechanisms, and reduce routine maintenance. renewal - use virtual prototyping to reduce production and testing facilities for stockpile requalification and replacement work.
Bicriterion Shortest Path Problem with a General Nonadditive Cost (2013)

A bicriterion shortest path problem with a general nonadditive cost seeks to optimize a combination of two path costs, one of which is evaluated by a nonlinear function. This paper first identifies a number of emerging transportation applications for which such a shortest path problem might be considered a core subproblem. We propose to first approximate the general nonlinear cost function with a piecewise linear counterpart, and then solve each linear subproblem sequentially. A specialized algorithm is developed to solve the subproblems, which makes use of the efficient path set (or the convex hull) to update upper and lower bounds of the original problem. Conditions under which the solution to a subproblem must belong to the efficient path set are specified. Accordingly, we show that the optimal path must be efficient if the nonlinear cost function is concave. If the optimal path to a subproblem is not efficient, partial path enumeration, implemented using a simple K-shortest path ranking procedure, is conducted to close the gap. The proposed algorithm includes strategies aiming to expedite path enumeration by using upper bounds derived from the efficient path set. Numerical experiments are conducted to demonstrate correctness and effectiveness of the proposed algorithm.
Toward accurate computation of optically reconstructed holograms (1991)

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Architecture, 1991.
Homology Cloning of GTP-cydohydrolase I from Fungi and Plants by Reverse-transcription PCR Using a General Set of Degenerate Primers (1995)

Summary Unconjugated pteridines are present in fungi, algae and plants. However, the functions of pteridines in these organisms are not thoroughly investigated. The biosynthesis follows the same steps as were shown for animals and eubacteria. One possible function of pteridines in these organisms is participation in blue-light reception. To analyze this or other functions of pteridines it would be useful to inhibit pteridine synthesis specifically by genetic engineering. GTP-cyclohydrolase I is the primary enzyme of tetrahydrobiopterin and folic acid biosynthesis. A comparison of amino acid sequences of GTP-cyclohydrolase I (EC 3.5.4.16) previously known from various species allowed the construction of degenerate primers, based on highly conserved regions. The same consensus primers are able to bind to cDNAs of unrelated eukaryotes. By reverse-transcriptase PCR cDNAs of the conserved C-terminal part of the fungi Neurospora and Phycomyces, the phytoflagellate Euglena and the higher plant Mucuna hassjoo were amplified and cloned. Similarities between the sequences agreed with the evolutionary relationship of the investigated organisms. Various regions strictly conserved between unrelated eukaryotes and bacteria were observed, which could be essential for the function of GTP-cyclohydrolase I.
Single- and multiple-dose pharmacokinetics of AM-1155, a new 6-fluoro-8-methoxy quinolone, in humans (1995)

The pharmacokinetics of AM-1155, a new 6-fluoro-8-methoxy quinolone, was examined in healthy male volunteers after the oral administration of a single dose of 100, 200, 400, or 600 mg and multiple doses of 300 mg twice daily for 6.5 days (13 total doses). Throughout the whole study period, AM-1155 was well tolerated in every subject. In the single-dose study, the concentrations in serum reached a peak between 1 and 2 h, and the peak concentrations were 0.873, 1.71, 3.35, and 5.41 micrograms/ml at the doses of 100, 200, 400, and 600 mg, respectively. The elimination half-life was 7 to 8 h, independently of the doses. The unchanged drug was excreted mainly in the urine, with 82 to 88% of the doses appearing for 72 h. The fecal recovery of the unchanged drug amounted to 5.7% for 72 h after a single oral administration of a 400-mg dose. Urinary excretion of metabolites was minimal. The serum protein binding was 20%, independently of the concentrations in serum. The concentrations in saliva were approximately 80% of those in serum. The intake of food had no effect on the pharmacokinetic parameters and urinary excretion of AM-1155 except the slight decrease in area under the concentration-time curve. The concurrent administration of probenecid prolonged the elimination half-life, increased the area under the concentration-time curve, and decreased the apparent total body clearance, renal clearance, urinary recovery of unchanged drug, and the excretion ratio (intrinsic renal clearance of AM-1155/creatinine clearance). This indicated that the tubular secretion contributed to the renal excretion of AM-1155. In the multiple-dose study, the concentrations of AM-1155 in serum and urine reached a steady state within 2 to 3 days. The measured concentrations in serum fitted well the simulation curve, which reflected the persistence of linear pharmacokinetics of AM-1155. In conclusion, AM-1155 is expected to be clinically useful because of its potent antibacterial activity and favorable pharmacokinetics.