gebhart/patrepeval huggingface dataset:
Specific cytotoxic T lymphocytes are involved in in vivo clearance of infectious bronchitis virus (1997)

Cytotoxic T-lymphocyte (CTL) responses to infectious bronchitis virus (IBV) were determined at regular intervals between 3 and 30 days postinfection (p.i.). The maximum response with 82% lysis of labeled target cells was detected at 10 days p.i. The specific CTL response did not begin to decline until the amount of virus, which peaked at day 8 p.i. in both the kidneys and lungs, started to decrease. Clinical respiratory signs of illness also correlated with amount of virus. CTL activity was shown to be major histocompatibility complex (MHC) class restricted because the lysis of MHC-mismatched targets was negligible, and lysis was mediated by CD8+ CD4- T cells, as the CTL response could be abolished with removal of CD8+ CD4- but not CD4+ CD8- lymphocytes. In contrast, immunoglobulin M (IgM) antibody was not detected until day 10 p.i., and levels peaked at day 12 p.i.; IgG antibody levels were minimal until day 15 p.i. but continued to increase exponentially until day 30 p.i., the last day examined. In summary, CTL responses correlated with initial decreases in infection and illness.
Protection from radiation enteritis by an absorbable polyglycolic acid mesh sling. (1987)

Patients with malignant tumors of the pelvis who cannot be cured surgically often are treated with radiation after surgery. A devastating side effect of this treatment is radiation-associated small bowel injury (RASBI). The purpose of this study was to test the hypothesis that removal of the small bowel from the radiation field would protect it against RASBI. Twenty cebus monkeys underwent low anterior resection. In 10 animals an absorbable polyglycolic acid (PGA) mesh was sewn circumferentially around the interior of the abdominal cavity as a supporting apron, which prevented the small bowel's descent into the pelvis. The other 10 monkeys did not receive the mesh. All animals received 2000 rads by linear acceleration in a single dose. Twenty-four-hour stool fat, serum vitamin B12, and other serum values were obtained during the study. Animals were sacrificed after 1, 2, 3, 6, and 12 months, and the small bowel and rectum were examined histologically in a blind manner. Two monkeys who did not undergo surgery, or exposure to radiation served as controls. At all sacrifice periods, the animals with PGA mesh slings demonstrated normal small bowel function and histologic structure. Animals without mesh slings had abnormal stool and blood values at 1 month, and by 2 months all had died of small bowel necrosis. The animals that received the slings had no evidence of infection or obstruction, and by 6 months all evidence of the mesh was gone. Support of the small bowel out of the pelvis by an absorbable PGA mesh sling protects against RASBI and is without apparent complications.
Evaluation of Plasma Insulin-like Growth Factor Binding Protein 2 and Her-2 Extracellular Domain as Biomarkers for 17-Allylamino-17-Demethoxygeldanamycin Treatment of Adult Patients with Advanced Solid Tumors (2007)

As previously reported, IGFBP-2 concentrations in plasma of cancer patients are significantly higher than those in healthy volunteers. In contrast to a mouse model, 17-AAG treatment was not consistently associated with decreases in IGFBP-2 or Her-2 ECD concentrations in patient plasma.
Slow resolution of multifocal weakness and fasciculation (1986)

A 25-year-old man with multifocal weakness and fasciculation was thought to have motor neuron disease. Signs progressed for 1 year, plateaued, and 3 years later resolved almost completely. There was no evidence of paraproteinemia, lymphoproliferative disorder, or vasculitis, and myelography was normal. Electrodiagnostic study disclosed multifocal, acute and chronic denervation that evolved into a picture consistent with residuals of old multifocal radiculopathy without active denervation. Prolongation of F response, absence of H-reflex, and conduction block in a proximal nerve segment suggested multifocal demyelination. A proximal motor neuropathy, perhaps demyelinating, may cause some of the benign motor neuron syndromes that simulate motor neuron disease.
Edible Protein from <i>Parthenium hysterophorus</i> (1978)

SUMMARY Leaf protein concentrate was prepared from the weed Parthenium hysterophorus L. and the nutritional properties of this preparation were studied in relation to its amino acid composition and digestibility. The product and the residual fibre closely resembled similar products made from conventional forage species.
Characterization of filament-assisted chemical vapor deposition diamond films using Raman spectroscopy (1989)

Results are presented on a Raman study of diamond films prepared by the filament-assisted chemical vapor deposition technique from a methane-hydrogen gas mixture. It is shown that Raman spectroscopy is a useful probe of both the phase of carbon present and of the quality of the diamond component in the films. The study entailed varying the total gas pressure, but holding the ratio of CH4 to H2 constant. It is clearly demonstrated that as the pressure is decreased, the density of defects within the diamond phase increases. The increase in defect density as the pressure is lowered leads eventually to disordered forms of carbon. This result can be understood in terms of the relatively higher electron and ion fluxes at the substrate for films prepared at low pressure.
Alpha-1 receptor mediated smooth muscle regulation in benign prostatic hyperplasia. (1994)

Symptoms in benign prostatic hyperplasia (BPH) are partially caused by an increased prostatic smooth muscle tone. This tone depends on extra- and intracellular Ca2+ stores and is regulated by various second messenger pathways. We investigated the role of intracellular Ca2+ stores and cyclic 3'-5' adenosine monophosphate (cAMP) in BPH. Contractions elicited by the specific alpha 1-receptor agonist phenylephrine (PE) were inhibited by the selective alpha 1-receptor antagonists prazosin and YM 617. To elucidate the contribution of intracellular Ca2+ stores to the alpha 1-receptor induced contraction nifedipine, a blocker of voltage dependent L-type Ca2+ channels (VDCC) was applied and found to inhibit the PE induced contractions up to 65%. To further confirm the participation of intracellular Ca2+ stores, we applied ryanodine (10 microM) which reduced the alpha 1-receptor mediated contractions up to 80%. The remaining contraction was sensitive to nifedipine. The cAMP pathway mediating smooth muscle relaxation by regulating intracellular Ca2+ concentrations ([Ca2+]i) was also investigated. Nonspecific phosphodiesterase (PDE) inhibitors such as papaverine (0.5 mM) and theophylline (1 mM) and the specific PDE inhibitor milrinone (0.5 mM), all of which prevent degradation of cAMP, suppressed the PE induced contractions by 82%, 91% and 68%, respectively. Forskolin (50 microM), an activator of adenylylecyclase (AC), inhibited the PE induced contractions by 83%. The membrane permeable cAMP analog, N6-2'-0-dibutyryladenosine derivative (dBcAMP) also reduced the PE induced response by 70%.
Learning to Find Object Boundaries Using Motion Cues (2007)

While great strides have been made in detecting and localizing specific objects in natural images, the bottom-up segmentation of unknown, generic objects remains a difficult challenge. We believe that occlusion can provide a strong cue for object segmentation and "pop-out", but detecting an object's occlusion boundaries using appearance alone is a difficult problem in itself. If the camera or the scene is moving, however, that motion provides an additional powerful indicator of occlusion. Thus, we use standard appearance cues (e.g. brightness/color gradient) in addition to motion cues that capture subtle differences in the relative surface motion (i.e. parallax) on either side of an occlusion boundary. We describe a learned local classifier and global inference approach which provide a frame-work for combining and reasoning about these appearance and motion cues to estimate which region boundaries of an initial over-segmentation correspond to object/occlusion boundaries in the scene. Through results on a dataset which contains short videos with labeled boundaries, we demonstrate the effectiveness of motion cues for this task.
Intramolecular cyclization of N-alkyl-3,3',4,4'-tetrahydro-1,1'-biisoquinolinium salts (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular cyclization of N-alkyl-3,3',4,4'-tetrahydro-1,1'-biisoquinolinium saltsRonald A. Henry and Donald W. MooreCite this: J. Org. Chem. 1972, 37, 12, 2039–2040Publication Date (Print):June 1, 1972Publication History Published online1 May 2002Published inissue 1 June 1972https://pubs.acs.org/doi/10.1021/jo00977a040https://doi.org/10.1021/jo00977a040research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Microfabrication of Optical Components in Synthetic Diamond : Infrared Optics for Applications in Astronomy and Spectroscopy (2018)

Infrared optics is a broad general term, relevant to a range of fields. The manufactured diamond optical components utilized within this thesis were applied to both astronomy, in which direct imagi ...
Spectral shaping of DAC nonlinearity errors through modulation of expected errors (2002)

Traditionally, delta-sigma modulation has been used for shaping of quantization noise. We present a modified version of delta-sigma modulation which also takes into account unwanted nonlinearities by feeding back not only the quantization error, but also the expected physical error. Behavioral-level simulations of a 5th-order structure showing an improvement of up to 4 effective bits are included.
A MEMS microphone interface with force-balancing and charge-control (2008)

This paper presents a low-power CMOS interface for a MEMS capacitive sensor. The interface has embedded force-balancing capability which improves the linearity of the readout for higher sound pressures. The interface also features a bias-charge control functionality to enhance the sensitivity of the microphone. The interface employs boot-strapped preamplifier for active parasitic capacitance compensation, followed by a 3rd-order sigma-delta modulator. The interface is designed in 0.35um CMOS technology and its brief simulation results in Cadence-Spectre are presented.
Organophosphorus Analogues and Derivatives of the Natural <scp>l</scp>-Amino Carboxylic Acids and Peptides. V. Synthesis of Analogues of Plumbemycin A (1988)

Abstract Analogues of antibiotic Plumbemycin A were synthesized by an exchange of d-norvaline residue with 1,2,3,6-tetrahydro-1,2-azaphosphorine and by coupling of alanylaspartic acid with N-terminal norvaline. The protecting groups were released by highly selective enzyme hydrolysis.
EXPERIMENTAL MANGANESE ENCEPHALOPATHY IN MONKEYS (1963)

Journal Article Experimental Manganese Encephalopathy in Monkeys: A Preliminary Report Get access Angel Pentschew, M.D., Angel Pentschew, M.D. Washington, D.C., and Baltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ford F. Ebner, 1st Lt., VC, USA, Ford F. Ebner, 1st Lt., VC, USA Washington, D.C., and Baltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert M. Kovatch, 1st Lt., VC, USA Robert M. Kovatch, 1st Lt., VC, USA Washington, D.C., and Baltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Neuropathology & Experimental Neurology, Volume 22, Issue 3, July 1963, Pages 488–499, https://doi.org/10.1097/00005072-196307000-00010 Published: 01 July 1963
The sarcoglycan complex in the six autosomal recessive limb-girdle muscular dystrophies (1996)

To enhance our understanding of the autosomal recessive limb-girdle muscular dystrophy (LGMD), patients from six genetically distinct forms (LGMD2A to LGMD2F) were studied with antibodies directed against four sarcoglycan subunits (alpha-, beta-, gamma-, delta-SG), dystrophin, beta-dystroglycan (beta-DG) and merosin. All patients with LGMD2A and 2B had a mild clinical course while those with a primary sarcoglycan mutation (LGMD2C to 2F) had a range of clinical severity. Dystrophin and merosin immunofluorescence pattern was positive in patients with all six AR LGMDs. The majority of patients with a severe Duchenne-like phenotype presented total absence of the SG complex. However, some exceptions were found in 13q linked patients, indicating that the presence of a certain labelling for components of the SG may not be prognostic for a milder phenotype. The observation that the primary absence of alpha-SG results in the total absence of beta- and delta-SG but not of gamma-SG suggests that the alpha-, beta- and delta-subunits of sarcoglycan may be more closely associated. A secondary reduction in dystrophin amount was seen in patients with primary sarcoglycan mutations, which was most marked in patients with primary beta-, gamma- and delta-SG deficiencies. In contrast, beta-DG staining was retained in all patients, suggesting that the association between SG and DG subcomplexes is not so strong. Based on the above findings, we have refined the model for the interaction among the known glycoproteins of the sarcoglycan complex, within the DGC.
Power dependence of dispersion-managed solitons for anomalous, zero, and normal path-average dispersion (1998)

We determine the power dependence of dispersion-managed solitons on map strength and average dispersion, using a combination of numerical simulations and the variational approach. In particular, we investigate the behavior near zero dispersion and identify the region of existence of dispersion-managed solitons in the average normal-dispersion regime.
Lazaroids U83836E and U74389G are Potent, Time‐Dependent Inhibitors of Caspase‐1 (2015)

Caspase-1 is involved in inflammatory processes and is overactive in autoimmunity and autoinflammation. Antioxidant small molecules also play a role in the immune response by decreasing inflammation. An 84-membered library of pro- and antioxidant small molecules was screened for potential inhibitors of caspase-1. Thirteen compounds were discovered to reduce the activity of caspase-1 below 30%. The most potent inhibitors were lazaroid antioxidant molecules, U83836E (B8) and U74389G (B9), displaying apparent Ki values of 48.0 and 50.0 nm, respectively. Both demonstrated a time-dependent and reversible inhibition.
Efficient management of memory hierarchies in embedded DRAM systems (1999)

The design and implementation of embedded microprocessors is on the verge of change -with MCM, flip-chip and integrated DRAM/ logic technologies moving from feasible to commercially viable.
Monolithic RF active mixer design (1999)

An overview of monolithic radio-frequency (RF) active mixer design is presented. The paper is divided into two parts. The first part discusses the performance parameters that are relevant to the design of downconversion mixers, and how they affect the system performance. The second part presents three common kinds of mixer topologies, namely, unbalanced, single-balanced, and double-balanced designs. This paper concentrates on active mixers only, The advantages and disadvantages, as well as the design and optimization techniques for the three kinds of mixers, are discussed.
Chemotherapeutic Sensitization of Leptomycin B Resistant Lung Cancer Cells by Pretreatment with Doxorubicin (2012)

The development of novel targeted therapies has become an important research focus for lung cancer treatment. Our previous study has shown leptomycin B (LMB) significantly inhibited proliferation of lung cancer cells; however, p53 wild type lung cancer cells were resistant to LMB. Therefore, the objective of this study was to develop and evaluate a novel therapeutic strategy to sensitize LMB-resistant lung cancer cells by combining LMB and doxorubicin (DOX). Among the different treatment regimens, pretreatment with DOX (pre-DOX) and subsequent treatment with LMB to A549 cells significantly decreased the 50% inhibitory concentration (IC50) as compared to that of LMB alone (4.4 nM vs. 10.6 nM, P<0.05). Analysis of cell cycle and apoptosis by flow cytometry further confirmed the cytotoxic data. To investigate molecular mechanisms for this drug combination effects, p53 pathways were analyzed by Western blot, and nuclear proteome was evaluated by two dimensional-difference gel electrophoresis (2D-DIGE) and mass spectrometry. In comparison with control groups, the levels of p53, phospho-p53 (ser15), and p21 proteins were significantly increased while phospho-p53 (Thr55) and survivin were significantly decreased after treatments of pre-DOX and LMB (P<0.05). The 2D-DIGE/MS analysis identified that sequestosome 1 (SQSTM1/p62) had a significant increase in pre-DOX and LMB-treated cells (P<0.05). In conclusion, our results suggest that drug-resistant lung cancer cells with p53 wild type could be sensitized to cell death by scheduled combination treatment of DOX and LMB through activating and restoring p53 as well as potentially other signaling pathway(s) involving sequestosome 1.
Agonist-induced regulation of mitochondrial and endoplasmic reticulum motility (2005)

Using fluorescently tagged markers for organelles in conjunction with confocal microscopy, we have studied the effects of agonist-induced Ca2+ signals on the motility of mitochondria and the ER (endoplasmic reticulum). We observed that the muscarinic agonist carbachol produced a rapid, simultaneous and reversible cessation of the movements of both organelles, which was dependent on a rise in cytosolic Ca2+. This rise in Ca2+ was shown to cause a fall in cellular ATP levels, and the effect of carbachol on organelle movement could be mimicked by depleting ATP with metabolic inhibitors in the absence of any such rise in Ca2+. However, a Ca2+-sensing process independent of ATP appears also to be involved, because we identified conditions where the ATP depletion was blocked (by inhibitors of the Ca2+ pumps), but the organelle movements still ceased following a rise in cytosolic Ca2+. We conclude that the co-ordinated cessation of mitochondria and ER motility is a process regulated by the cytosolic concentration of both Ca2+ and ATP, and that these two parameters are likely to synergize to regulate the localization of the two organelles, and to facilitate the transfer of Ca2+ between them.
Transient gene expression in shoot apical meristems of sugarbeet seedlings after particle bombardment (1995)

Sugarbeet apices were used as targets for particle bombardment with a microtargeting device. Before examining gene expression, particle penetration experiments were carried out. Transient GUS expression was detected within the first and second cell layers of the meristem. Dividing cells with GUS activity demonstrated that cells survived the bombardment procedure.
Spin-valve read heads for tape applications (1999)

Shielded spin-valve tape heads with permanent magnet stabilization are described. Final MR of 3.5% is shown on heads with trackwidths of 5 and 9 /spl mu/m, and sensor heights of 0.5, 1.0 and 1.5 /spl mu/m. Heads are characterized on 1/2 " DLT-IV tape up to 180 kfci. For isolated transitions the heads show a PW/sub 50/ of 0.8 /spl mu/m (pulse broadening due to partial head saturation) and a baseline shift /spl sim/10% that can be positive or negative, and is related with shield remanence and transfer curve hysteresis. At 120 kfci, head output for a sense current of 3 to 4 mA is /spl sim/1 mV/sub pp/ (up to 30% of the output at 30 kfci). At high linear densities, signal loss is 0.24 dB/kfci for a 0.35 /spl mu/m shield-to-shield spacing (D/sub 50/ of 80/spl sim/100 kfci). At low linear densities the head is partially saturated, and above 60 kfci harmonic distortion is lower than -20 dB.
A faster UDP (user datagram protocol) (1993)

As an experiment in protocol optimizations, the authors undertook to improve the performance of a stateless protocol, namely the user datagram protocol (UDP) in the 4.3 BSD Unix kernel. The authors describe the successful optimizations that were done, along with measurements that shows a UDP performance improvement of between 25-35% on CISC and RISC systems, and overall kernal improvement of between 12% and 18%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Ulexite, NaCaB<5) O<6) (OH)<6) .5H<2) O; structure refinement, polyanion configuration, hydrogen bonding, and fiber optics (1978)

The crystal structure of ulexite, NaCaBsOe(OH)6.5HrO, PT. has been refined to a conventional R:0.046 using least-squares methods, partially block-diagonal, for 49ll reflections collected on a single-crystal diffractometer with graphite-monochromatized Mo radiation. AII l6 hydrogen atoms in the asymmetric unit were located, and all form hydrogen bonds.Refinedcel lconstantsare:d= 8.816(3),b=12.87 0(7),c=6.678(l)A ,a:90.36(2), B : 109.05(2)', 7 = 104.98(4), V : 688.4(4) A3,2 :2, density (calc) = 1.955 g/cm3. The structure contains isolated pentaborate-type polyanions composed of three tetrahedra and two triangles, plus chains of Na octahedra and chains of Ca polyhedra, all cross-linked by polyanion bonds to the cations and by a network of hydrogen bonds. Average bond distances (A) are: B-O, tetrahedrall.4T5,
ANY NEW PROTEOMICS TECHNIQUES OUT THERE? (2001)

RETURN TO ISSUEPREVNewsNEXTANY NEW PROTEOMICS TECHNIQUES OUT THERE?Genome project head says many technologies for a human proteome project are not yet readySTU BORMANView Author Information C&EN WASHINGTONCite this: Chem. Eng. News 2001, 79, 48, 27–29Publication Date (Print):November 26, 2001Publication History Published online13 November 2010Published inissue 26 November 2001https://pubs.acs.org/doi/10.1021/cen-v079n048.p027https://doi.org/10.1021/cen-v079n048.p027newsACS PublicationsCopyright © 2001 American Chemical SocietyArticle Views8Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Genomics,Proteomics Get e-Alerts