gebhart/patrepeval huggingface dataset:
HETERGOGENOUS DEVICE CONTEXT AWARE INFORMATION DISSEMINATION (2013)

Abstract: This paper focus on device aware context delivery with middleware based support for heterogeneous client devices. Data networks are increased tremendously to support heterogeneous devices. There are myriad of new portable computing devices that each have different capabilities with regard to communication platform, communication protocol, computing power, display capabilities etc. Middleware based provisioning of various services based on the device context is proposed in this paper. Our work focuses on identifying different type of handheld devices based on the context of the device. Based on the device context (DC), the necessary services are served from the dynamic web server to the clients. The device identifier object provides the necessary information related to the context of the heterogeneous device (clients). This enables the server to provide the required information as per the context of the device. Our approach is generic in nature to support any kind of device context in an efficient way for different kind of application in a heterogeneous platform. The experimental results provide best solution for the forth-coming devices based on its context. This paper overcomes the deficiencies and limitation of existing device-aware computing by providing a suitable system and mechanism for device aware content delivery. 1.
Comparative study of supported CuOx and MnOx catalysts for the catalytic wet air oxidation of beta-naphthol (2012)

MnO x /nano-TiO 2 , MnO x /Al 2 O 3 -TiO 2 (Al-Ti), CuO x /nano-TiO 2 and CuO x /Al-Ti were prepared and their application in catalytic wet air oxidation (CWAO) of beta-naphthol were investigated. The catalysts had been characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and temperature-programmed reduction (TPR) measurements. Phases of CuO, Cu 2 O, CuAl 2 O 4 , MnO 2 and Mn 2 O 3 could be found on the surface of the aforementioned catalysts. Significant differences in activities were observed among the prepared catalysts. Compared to CuO x /nano-TiO 2 , the combined action of highly dispersed CuO as well as CuAl 2 O 4 of CuO x /Al-Ti helped to achieve higher activity for the CWAO of beta-naphthol, while the Cu 2 O component lead to lower efficiency of CuO x /nano-TiO 2 . On the surface of MnO x /nano-TiO 2 , both the larger amount of highly dispersed MnO 2 and the stronger electron transfer between MnO 2 and Mn 2 O 3 were helpful to promote the activity for the degradation of beta-naphthol. However, the higher amount of bulk MnO 2 and the weaker electron transfer for MnO x /Al-Ti were unfavorable to increase its efficiency. Among the four catalysts as-prepared, MnO x /nano-TiO 2 was identified the highest activity with 93.7% COD removal.
Bis[3,5‐bis(benzylidene)‐4‐oxo‐1‐piperidinyl]amides: A Novel Class of Potent Cytotoxins (2011)

The principal objective of this study was the examination of the theory of cytotoxic synergism. In this exploratory study, we tested the hypothesis that doubling the number of sites available for thiol alkylation in a series of candidate cytotoxins increases potency more than two-fold. This concept was verified in one-third of our comparisons using human Molt 4/C8 and CEM T-lymphocytes and murine L1210 cells. In addition, the significant potencies of various members of our compound series justified further studies. Molecular modeling revealed that relative locations of the amidic groups correlate with cytotoxicity. A potent cytotoxic compound, 1,2-bis(3,5-dibenzylidene-4-oxo-piperidin-1-yl)ethane-1,2-dione (1a) inhibited the growth of a large number of human tumor cell lines and displayed greater toxicity toward certain non-adherent cells than toward adherent neoplasms or fibroblasts. The mode of action of 1a includes induction of apoptosis and necrosis.
Executing loops on a fine-grained MIMD architecture (1991)

We present techniques for exploiting parallelism extracted from loops on an MIMD system. Parallelism is exploited through parallel execution of instructions on multiple processors as well as pipelined nature of individual processors. The processors based upon the load/store architecture read/write operands frotn/to private registers, shared registers, and channel queues. If the communication of a vahte from one processor to another requires synchronization then a channel is used otherwise a shared register is used to communicate the vahte. The reeeiving processor reads the values from a channel queue in the order they are written to the channel by the sending processor. The scheduling of operations is carried out in a manner that reduces interprocessor communication. Such schedules reduce the likelihood of one processor impeding the progress of other processors.
Model-based 2D&3D dominant motion estimation for mosaicing and video representation (2002)

It is fairly common in video sequences that a mostly fixed background (scene) is imaged with or without objects. The dominant background changes in the image plane mostly due to camera operations and motion (zoom, pan, tilt, track etc.). We address the problem of computation of the dominant image transformation over time and demonstrate how this can be effectively used for efficient video representation through video mosaicing and image registration. We formulate the problem of dominant component estimation as that of model based robust estimation using M estimators with direct, multi resolution methods. In addition to 2D affine and plane projective models, that have been used in the past for describing image motion using direct methods, we also employ a true 3D model of motion and scene structure imaged with uncalibrated cameras. This model parameterizes the image motion as that due to a planar component and a parallax component. For rigid 3D scenes imaged under camera motion only, least squares (LS) methods with the plane and parallax parameterization are also presented. Furthermore, in the context of robust estimation, in contrast with previous approaches for similar problems, our algorithm employs an automatic computation of a scale parameter that is crucial in rejecting the non dominant components as outliers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Proposed Hydrogenation/Nitridization Passivation Mechanism for GaAs and Other III–V Semiconductor Devices, Including InGaAs Long Wavelength Photodetectors (1982)

A surface passivation method for , with possible extensions to and , is proposed. For , a correlation between recent device work (on solar cells, field effect transistors, MOS devices, and photodiodes) and the experimental Ga‐As‐O phase diagram provides strong evidence of the role of elemental surface or interface arsenic or arsenic oxide in device performance degradation. On this basis, a hydrogenation/nitridization passivation technique is proposed. The reactions to remove surface As and are
Using the Master's Tools to Dismantle the Master's House:<i>The Fountainhead</i>Reads<i>Doctor Faustus</i> (2018)

Abstract Largely by the use of allegory, Ayn Rand's novel The Fountainhead repurposes and reinterprets the religious morality of Christopher Marlowe's Doctor Faustus to espouse an Objectivist, rather than theist, view of salvation and damnation. The Faustian narrative no longer belongs to Faustus alone, but is read against itself in order to theorize that giving up one's ego and independence, rather than giving up one's membership to the societal collective, is the straightest road to perdition.
Comparison of effectiveness of removal of nuisance anions by metalloligs, metal derivatives of Octolig® (2008)

The present study describes the effectiveness of removal of selected aqueous anions by several metalloligs, i.e., metal derivatives of a commercially available immobilized ligand, IMLIG, Octolig. This material consists of polyethylenediamine moieties covalently bound to a high-surface area silica gel (CAS Registry number = 404899-06-5). The metals involved are copper, cobalt, iron, nickel, manganese, and thorium. The nuisance anions, studied as aqueous solutions, were arsenate, orthophosphate, selenite, sulfate, nitrate, and nitrite. All six metalloligs tested were able to remove arsenate (280 ppb, > 99% removal) effectively. The effectiveness for other anions varied, but all anions were removed by one metallolig or another. For example, for Colbaltilig, in deionized water samples, removal was 96% for 20.9 ppm NO(3)-N, 98% for 29.6 ppm sulfate (as sodium sulfate). For Cuprilig, removal was 98% for 9.82 ppm boron as boric acid, > 99% for Cr as 212 ppm dichromate, 97% for P as 10 ppm HPO(4)-P, and 90% for sulfate as 29 ppm sulfate. Removal of nitrate by Cobaltilig appeared to be adversely affected by the presence of sulfate. Manganilig and Nickelig were able to remove > 97% of 10 ppm P as Na(2)HPO(4). Mechanisms of interaction are proposed that suggest six types of behavior and several classes of materials are represented by these metalloligs.
Investigation of surface roughness characterization using an ART2 neural network (1991)

Surface roughness is an important quality of surfaces. A shortcoming of currently used techniques for characterizing surface roughness is the absence of a single descriptive number that can be used to differentiate the roughness of different surfaces. This paper discusses the development of an Adaptive Resonance Theory (ART2) neural network-based approach for surface roughness analysis. The objective is to develop a unique, more descriptive parameter of surface roughness. ART2 neural networks offer an attractive approach to classify sensory data such as surface roughness profiles, since they have the capability of classifying the data in a self-scaling, unsupervised fashion, and of deciphering the data's invariant properties. In this paper, an ART2 network structure is enhanced to enable the network to address the need of attributing a single numerical value to each classified category. The above methodology was tested on six simulated surfaces and the results obtained showed that the ART2 network is capable of classifying each surface into a distinct category and assigning a roughness index to each category that is more descriptive than the commonly used CLA parameter. However, further work is still needed to obtain the ultimate single number index.
Using the Weibull Distribution: Reliability, Modeling, and Inference (2012)

Understand and utilize the latest developments in Weibull inferential methods While the Weibull distribution is widely used in science and engineering, most engineers do not have the necessary statistical training to implement the methodology effectively. Using the Weibull Distribution: Reliability, Modeling, and Inference fills a gap in the current literature on the topic, introducing a self-contained presentation of the probabilistic basis for the methodology while providing powerful techniques for extracting information from data. The author explains the use of the Weibull distribution
Antimicrobial Activity of 3-<i>O</i>-Acyl-(-)-epicatechin and 3-<i>O</i>-Acyl-(+)-catechin derivatives (2004)

As an exploratory investigation of antimicrobial promoting compounds, 3- O-acyl-(-)-epicatechins and 3- O-acyl-(+)-catechins possessing various aromatic groups and aliphatic chains of varying length from C4 to C16 for increasing lipophilicity were synthesized and tested for antimicrobial activities against Gram-positive, Gram-negative bacteria and fungi. The (-)-epicatechin and (+)-catechin derivatives comprised of aromatic groups increased activity and derivatives with acyl chain groups of carbon atoms in the close vicinity of C8 to C10 showed strong antimicrobial activity (MIC = 2 - 8 microg/ml) against Gram-positive bacteria and weak activity against fungi. However, the activity decreased when the carbon chain length of the substituents was too short (C4 to C6) or too long (C16). These results suggest that the presence of lipophilic substituents with moderate sizes might be crucial for the optimal antimicrobial activity.
Bleomycin-induced pulmonary fibrosis. Effects of steroid on lung collagen metabolism. (1981)

Using bleomycin-induced pulmonary fibrosis as a model, we have set out to study collagen metabolism in the fibrotic process. As was previously shown, intratracheal administration of bleomycin in the rat caused increased deposition and net synthesis of collagen in the lung. This was accompanied by marked increases in the tissue-free proline pool size and less dramatic increases in the pool's radioactivity when lung mince was pulsed with radioactive proline to measure the net collagen synthesis. Using a technique based on the quantitation of the rate of release of hydroxyproline-containing peptides when lung homogenates were incubated in calcium-containing buffer, lung collagenolytic activity was markedly diminished as a result of bleomycin treatment. Concomitant treatment with the steroid methylprednisolone did not affect significantly this decrease in lung collagenolytic activity. Such steroid treatment, however, prevented the increase in bleomycin-induced lung collagen deposition and partially suppressed total lung collagen synthesis, without affecting the net rate of lung collagen synthesis expressed per mg of DNA. Steroid treatment also inhibited the marked increase in tissue-free proline pool size and radioactivity caused by bleomycin. The mechanism of amelioration of the fibrotic response by the steroid is discussed.
Characterization of Ad5 E3–14.7K, an adenoviral inhibitor of apoptosis: Structure, oligomeric state, and metal binding (2002)

The adenovirus E3-14.7K protein, expressed early in the life cycle of human adenoviruses to protect the virus from the antiviral response of host cells, inhibits cell death mediated by TNF-alpha and FasL receptors. To better understand its role in cell death inhibition, we have sought to characterize the biophysical properties of the protein from adenovirus serotype 5 (Ad5 E3-14.7K, or simply 14.7K) through a variety of approaches. To obtain sufficient quantities of recombinantly expressed protein for biophysical characterization, we explored the use of various expression constructs and chaperones; fusion to MBP was by far the most effective at generating soluble protein. Using limited proteolysis, mass spectrometry, and protein-protein interaction assays, we demonstrate that the C-terminal two-thirds of the protein, predicted to be composed of five beta-strands and one alpha-helix, is highly structured and binds its putative cellular receptors. Furthermore, using atomic absorption and ultraviolet/visible spectroscopies, we have studied the metal binding properties of the protein, providing insight into the observation that cysteine/serine mutants of 14.7K lack in vivo antiapoptotic activity. Lastly, results from size exclusion chromatography, dynamic light scattering, sucrose gradient sedimentation, chemical crosslinking, and electron microscopy experiments revealed that 14.7K exists in a stable high-order oligomeric state (nonamer) in solution.
HOXC8 Inhibits Androgen Receptor Signaling in Human Prostate Cancer Cells by Inhibiting SRC-3 Recruitment to Direct Androgen Target Genes (2010)

HOX (homeobox) genes encode homeodomain-containing transcription factors critical to development, differentiation, and homeostasis. Their dysregulation has been implicated in a variety of cancers. Previously, we showed that a subset of genes of the HOXC cluster is upregulated in primary prostate tumors, lymph node metastases, and malignant prostate cell lines. In the present study, we show that HOXC8 inhibits androgen receptor (AR)-mediated gene induction in LNCaP prostate cancer cells and HPr-1 AR, a nontumorigenic prostate epithelial cell line. Mechanistically, HOXC8 blocks the AR-dependent recruitment of the steroid receptor coactivators steroid receptor coactivator-3 (SRC-3), and CREB binding protein to the androgen-regulated prostate-specific antigen gene enhancer and inhibits histone acetylation of androgen-regulated genes. Inhibition of androgen induction by HOXC8 is reversed upon expression of SRC-3, a member of the SRC/p160 steroid receptor cofactor family. Coimmunoprecipitation studies show that HOXC8 expression inhibits the hormone-dependent interaction of AR and SRC-3. Finally, HOXC8 expression increases invasion in HPr-1 AR nontumorigenic cells. These data suggest a complex role for HOXC8 in prostate cancer, promoting invasiveness while inhibiting AR-mediated gene induction at androgen response element-regulated genes associated with differentiated function of the prostate. A greater understanding of HOXC8 actions in the prostate and its interactions with androgen signaling pathways may elucidate mechanisms driving the onset and progression of prostate cancer.
Approximate modified policy iteration and its application to the game of Tetris (2015)

International audience
Biocommodities from photosynthetic microorganisms (2013)

Photosynthetic microorganisms are able to produce a diverse array of renewable biochemical commodities. Although promising platforms for the accumulation of targeted products, these organisms must be optimized in solar energy conversion, carbon capture and utilization, and the partitioning of metabolic flux to the requisite biosynthetic pathways. Metabolic engineering efforts are systematically addressing these obstacles and demonstrate the potential to develop consolidated bioprocessing organisms that are able to efficiently transform the energy in sunlight directly to refined chemicals of economic value. Particularly intriguing are mechanisms to synthesize and secrete bioproducts of interest from cyanobacteria, thereby eliminating the need to dewater and process cellular biomass. Significant advances in more classical approaches to triacylglycerol and carbohydrate accumulation in algae have also recently been realized. Importantly, genetic tools and sequenced genomes are emerging for some of the most biotechnologically relevant strains. © 2013 American Institute of Chemical Engineers Environ Prog, 32: 989–1001, 2013
Contaminated patellar tendon grafts: Incidence of positive cultures and efficacy of an antibiotic solution soak—An in vitro study (1991)

The incidence of positive cultures after contamination of sterile patellar tendon grafts in an operating room environment was studied in 10 specimens. The grafts were dropped on the floor for 3 min and then cultured. Six of the 10 grafts (60%) had a positive culture at 10 days. To test the efficacy of an antibiotic solution on cleansing contaminated grafts, 10 additional grafts were dropped on the floor for 3 min. Before the grafts were cultured they were soaked in a sterile saline solution containing bacitracin (33.33 U/ml) and polymyxin B (333.33 U/ml) for 15 min. Thirty percent of these grafts (3 of 10) cultured positive at 10 days. In each case the bacterial contaminant was found to be sensitive to one of the antibiotic agents used in the cleansing solution. The results of this study suggest that although soaking contaminated grafts in this antibiotic solution for 15 min may reduce the incidence of positive cultures, it still results in a 30% incidence of nonsterile grafts.
Guided region prefetching: a cooperative hardware/software approach (2004)

Despite large caches, main-memory access latencies still cause significant performance losses in many applications. Numerous hardware and software prefetching schemes have been proposed to tolerate these latencies. Software prefetching typically provides better prefetch accuracy than hardware, but is limited by prefetch instruction overheads and the compiler's limited ability to schedule prefetches sufficiently far in advance to cover level-two cache miss latencies. Hardware prefetching can be effective at hiding these large latencies, but generates many useless prefetches and consumes considerable memory bandwidth. We propose a cooperative hardware-software prefetching scheme called guided region prefetching (GRP), which uses compiler-generated hints encoded in load instructions to regulate an aggressive hardware prefetching engine. We compare GRP against a sophisticated pure hardware stride prefetcher and a scheduled region prefetching (SRP) engine. SRP and GRP show the best performance, with respective 22% and 21% gains over no prefetching, but SRP incurs 180% extra memory traffic-nearly tripling bandwidth requirements. GRP achieves performance close to SRP, but with a mere eighth of the extra prefetching traffic, a 23% increase over no prefetching. The GRP hardware-software collaboration thus combines the accuracy of compiler-based program analysis with the performance potential of aggressive hardware prefetching, bringing the performance gap versus a perfect L2 cache under 20%.
T Cell Memory Response to Pneumococcal Protein Antigens in an Area of High Pneumococcal Carriage and Disease (2009)

In this population, T cell-mediated immunological memory potentially capable of pathogen clearance and immune surveillance is common but is not associated with the absolute interruption of pneumococcal carriage. How this naturally acquired immune memory influences pneumococcal vaccine efficacy remains to be determined.
Myosin Phosphatase and Cofilin Mediate cAMP/cAMP-dependent Protein Kinase-induced Decline in Endothelial Cell Isometric Tension and Myosin II Regulatory Light Chain Phosphorylation (2005)

This study determined the effects of increased intracellular cAMP and cAMP-dependent protein kinase activation on endothelial cell basal and thrombin-induced isometric tension development. Elevation of cAMP and maximal cAMP-dependent protein kinase activation induced by 10 microm forskolin, 40 microm 3-isobutyl-1-methylxanthine caused a 50% reduction in myosin II regulatory light chain (RLC) phosphorylation and a 35% drop in isometric tension, but it did not inhibit thrombin-stimulated increases in RLC phosphorylation and isometric tension. Elevation of cAMP did not alter myosin light chain kinase catalytic activity. However, direct inhibition of myosin light chain kinase with KT5926 resulted in a 90% decrease in RLC phosphorylation and only a minimal decrease in isometric tension, but it prevented thrombin-induced increases in RLC phosphorylation and isometric tension development. We showed that elevated cAMP increases phosphorylation of RhoA 10-fold, and this is accompanied by a 60% decrease in RhoA activity and a 78% increase in RLC phosphatase activity. Evidence is presented that it is this inactivation of RhoA that regulates the decrease in isometric tension through a pathway involving cofilin. Activated cofilin correlates with increased F-actin severing activity in cell extracts from monolayers treated with forskolin/3-isobutyl-1-methylxanthine. Pretreatment of cultures with tautomycin, a protein phosphatase type 1 inhibitor, blocked the effect of cAMP on 1) the dephosphorylation of cofilin, 2) the decrease in RLC phosphorylation, and 3) the decrease in isometric tension. Together, these data provide in vivo evidence that elevated intracellular cAMP regulates endothelial cell isometric tension and RLC phosphorylation through inhibition of RhoA signaling and its downstream pathways that regulate myosin II activity and actin reorganization.