gebhart/patrepeval huggingface dataset:
Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines (1995)

CD40 is a member of the nerve growth factor receptor family, showing a significant homology to the Hodgkin's disease (HD)-associated antigen CD30 and is capable of transduce growth signals in a number of cell types. A series of 312 lymphoma samples, including 139 cases of HD, 32 cases of CD30+ anaplastic large cell (ALC) lymphomas, 141 cases of other non-Hodgkin's lymphomas (NHLs), and a panel of HD- or NHL-derived cell lines, were evaluated for CD40 expression by immunostaining of paraffin embedded sections, cell smears and flow cytometry. CD40 was strongly expressed with a highly distinct pattern of staining on Reed-Sternberg (RS) cells and variants in 100% (139/139) of HD cases, irrespective of their antigenic phenotype (T, B, non T-non B) and histologic subtype of HD. Conversely, CD40 was immunodetected on only one third (12/32; 37%) of ALC lymphoma cases and on 105 of 127 B-cell NHLs. The relative cell density of CD40 on HD cell lines (L-428, KM-H2, HDLM-2) as assessed by flow cytometry was significantly higher than on all other lymphoma cells analyzed. Engagement of CD40 by its soluble ligand (CD40L) enhanced both clonogenic capacity and colony cell survival of HD cell lines. Such effect was potentiated by interleukin-9 costimulation in KM-H2 cells. Finally, we have shown that in vitro rosetting of activated CD4+ T cells to HD cells (L-428) is mediated in part by the CD40/CD40L adhesion pathway. Our data indicate that CD40 is a useful antigen for immunodetection and identification of tumor cells in all subtypes of HD, and suggest that it may play a role in the regulation of RS cell expansion and the contact-dependent interactions of these cells with cytokine-producing T lymphocytes.
CorrectDB (2013)

Clients of outsourced databases need Query Authentication (QA) guaranteeing the integrity (correctness and completeness), and authenticity of the query results returned by potentially compromised providers. Existing results provide QA assurances for a limited class of queries by deploying several software cryptographic constructs. Here, we show that, to achieve QA, however, it is significantly cheaper and more practical to deploy server-hosted, tamper-proof co-processors, despite their higher acquisition costs. Further, this provides the ability to handle arbitrary queries. To reach this insight, we extensively survey existing QA work and identify interdependencies and efficiency relationships. We then introduce CorrectDB, a new DBMS with full QA assurances, leveraging server-hosted, tamper-proof, trusted hardware in close proximity to the outsourced data.
Interporous Hydroxyapatite as a Bone Graft Substitute in Tibial Plateau Fractures (1989)

The metaphyseal defects in 40 patients with displaced tibial plateau fractures necessitating surgical repair were filled with either cancellous autograft or interporous hydroxyapatite. Roentgenographic and clinical assessments at follow-up periods averaging 15.4 months (autograft) and 34.5 months (hydroxyapatite) demonstrated no significant differences in the two groups. Interporous hydroxyapatite is a safe, effective alternative to autogenous cancellous bone for the filling of metaphyseal defects associated with tibial plateau fractures.
Reaktionen an Indolderivaten, XXVIII. Alkylierung von Camptothecin‐Vorstufen—/ein neuer Weg zum Camptothecin (1975)

Abstract Unter Verwendung ringoffener Vorstufen gelingt die Einführung der Äthylgruppe des Camptothecins in guter Ausbeute. Über einige Verbesserungen des Synthesewegs wird berichtet.
Cryptography and decoding reed-solomon codes as a hard problem (2005)

Some recent developments in employing Reed-Solomon codes in cryptography are surveyed, including the design of symmetric ciphers and what provable properties one can argue based on suitable hardness assumptions (for parameters where decoding is hard).
Enhanced nitrogen diffusion in 4H-SiC (2002)

Experimental evidence is given for boron (B) enhanced diffusion of nitrogen (N) in ion-implanted 4H silicon carbide (4H-SiC), when a nitrogen implant is co-doped within an existing boron p-type well. The co-implanted nitrogen is shown to diffuse continuously with time when samples are annealed at 1600 °C—with little movement of the boron p-well implant profile. An effective nitrogen in boron diffusivity at 1600 °C is determined to be at least 60 times larger than that of a mono-doped nitrogen implant.
Population pharmacokinetics of melphalan in patients with multiple myeloma undergoing high dose therapy (2010)

Creatinine clearance, fat free mass and haematocrit influence total and unbound melphalan plasma clearance. Melphalan exposure is related to melphalan toxicity while the association with efficacy shows promising trends that will be studied further.
Methods and options for the heterologous production of complex natural products (2010)

This review will detail the motivations, experimental approaches, and growing list of successful cases associated with the heterologous production of complex natural products.
Metodología para la evaluación de la calidad en los modelos UML (2010)

"Este artículo presenta una metodología para la evaluación de la calidad de modelos UML, formada por un conjunto estructurado de procesos, orientada a la relación con el cliente y a la externalización de la evaluación de la calidad, y además pensada para ser unametodología fácilmente adaptable."
Use of ethylaluminum dichloride as a catalyst for the Friedel-Crafts acylation of alkenes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of ethylaluminum dichloride as a catalyst for the Friedel-Crafts acylation of alkenesBarry B. Snider and Andrew C. JacksonCite this: J. Org. Chem. 1982, 47, 27, 5393–5395Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/jo00148a032https://doi.org/10.1021/jo00148a032research-articleACS PublicationsRequest reuse permissionsArticle Views600Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Utility of <i>R</i> ‐Curves for Understanding Fracture Toughness‐Strength Relations in Bridging Ceramics (2008)

The mechanical behavior of four rare earth (RE)‐Mg‐doped Si 3 N 4 ceramics (RE=La, Lu, Y, Yb) with varying grain‐boundary adhesion has been examined with emphasis on materials containing La and Lu (which represent the extremes of RE ionic radius). Fracture‐resistance curves ( R ‐curves) for all ceramics rose very steeply initially, giving them exceptional strength and relative insensitivity to flaw size. The highest strength was seen in the Lu‐doped material, which may be explained by its steeper initial R ‐curve; the highest “apparent” toughness (for fracture from millimeter‐scale micronotches) was seen in the lowest strength La‐doped material, which may be explained by its slowly rising R ‐curve at longer crack lengths. Excellent agreement was found between the predicted strengths from R ‐curves and the actual strengths for failures originating from natural flaws, a result attributed to careful estimation of the early part of the R ‐curve by deducing the intrinsic toughness, K 0 , and the fact that this portion of the R ‐curve is relatively insensitive to sample geometry. Finally, it was found that RE elements with relatively large ionic radius (e.g., La) tended to result in lower grain‐boundary adhesion. This implies that there is a small window of optimal grain‐boundary adhesion which can lead to the fastest rising R ‐curves (for short cracks) and the highest strengths. The importance of this work is that it reinforces the notion that factors which contribute to the early part of the R ‐curve are critical for the design of ceramic microstructures with both high strength and high toughness.
The structure of Eurropean Community R&D policy: opportunities and limits (1993)

Abstract At present the future structure and development of European Community research and development (R&D) policies and programmes are being widely discussed. This paper is intended to assist those following the debate by setting out the background and some of the major issues including those raised by the Maastricht Treaty.
A Dynamic Planning and Control System for Inventories of Raw Materials. (1988)

Interfaces with operational MRP II systems can realize substantial benefits in warehousing management and control. This paper presents the design, development, programming and implementation of an inventory planning system, which, in coordination with MRP II, provides significant potential for increased stock turns, and reduced cash flow and storage space requirements. Finally, it presents a multi-objective ABC class analysis, combined with a method of calculating aggregate stock turns based on the turns of each item class.
Phosphate Homeostasis and Root Development in Arabidopsis Are Synchronized by the Zinc Finger Transcription Factor ZAT6 (2007)

Phosphorus availability is limited in many natural ecosystems. Plants adapt to phosphate (Pi) deficiency by complex molecular processes. There is growing evidence suggesting that transcription factors are key components in the regulation of these processes. In this study, we characterized the function of ZAT6 (zinc finger of Arabidopsis 6), a cysteine-2/histidine-2 zinc finger transcription factor that is responsive to Pi stress. ZAT6 is induced during Pi starvation and localizes to the nucleus. While the RNAi suppression of ZAT6 appeared to be lethal, its overexpression affects root development and retards seedling growth as a result of decreased Pi acquisition. The ZAT6 overexpression also resulted in altered root architecture of older plants, with consequent changes in Pi acquisition. These results indicate that ZAT6 regulates root development independent of the Pi status of the plant, thereby influencing Pi acquisition and homeostasis. In addition, the expression of several Pi starvation-responsive genes was decreased in ZAT6 overexpressing plants, thereby confirming the role of ZAT6 in regulating Pi homeostasis. This study thus indicates that ZAT6 is a repressor of primary root growth and regulates Pi homeostasis through the control of root architecture. To our knowledge, ZAT6 is the first cysteine-2/histidine-2 zinc finger transcription factor reported to regulate root development and nutrient stress responses.
Lipid-Soluble derivatives of 6-mercaptopurine (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLipid-Soluble derivatives of 6-mercaptopurineCarroll Temple Jr., Conrad L. Kussner, and John A. MontgomeryCite this: J. Med. Chem. 1968, 11, 1, 41–44Publication Date (Print):January 1, 1968Publication History Published online1 May 2002Published inissue 1 January 1968https://doi.org/10.1021/jm00307a008Request reuse permissionsArticle Views96Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (400 KB) Get e-Alertsclose Get e-Alerts
Action of single-strand specific nucleases on model DNA heteroduplexes of defined size and sequence (1977)

The sensitivity of the model DNAs containing dA-dG and dtg-dG heteroduplex regions of defined length to S1 and mung bean single-strand specific nucleases was tested by polyacrylamide gel electrophoretic analysis of the distribution of product oligonucleotides. Single-base mismatch heteroduplexes were extremely resistant to these nucleases, although low levels of cleavage at the heteroduplex nucleotide were observed at high nuclease concentrations. The nuclease sensitivity of dA-dtg heteroduplex regions increased gradually as the length of the heteroduplex region increased frome one to six nucleotides. The sensitivity of dG-dG heteroduplexes three to five nucleotides long was considerably greater than that of the single dtg-dG mismatch.
Evidence for control of serotonin secretion from human platelets by hydroxyl ion transport and osmotic lysis. (1977)

Serotonin secretion from human platelets, stimulated either by thrombin or the calcium ionophore A23187, was found to be inhibited by anion transport blocking drugs such as 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid (SITS), pyridoxal phosphate, probenecid, and suramin. These drugs have previously been shown to inhibit ATP-evoked release of epinephrine from isolated chromaffin granules by blocking chloride uptake and subsequent osmotic lysis. However, in contrast to granule release, platelet secretion was insensitive to chloride and, instead, was dependent on OH-. Platelet release was suppressed by low pH, and inhibition by the transport blocking drugs was competitive only with respect to OH-. Serotonin release from platelets was also suppressed by increasing extracellular osmotic strength, and the relationship between suppression and external osmotic strength was quantitatively similar to that observed in the case of chromaffin granules. We conclude that platelet exocytosis could occur when serotonergic granules are closely juxtaposed to the plasma membrane, thus exposing the granule anion transport site to the more alkaline medium. Secretion of serotonin could occur as a consequence of OH- transport and osmotic lysis of the granule-plasma membrane complex, analogous to the chemiosmotic mechanism of chloride-dependent epinephrine release from isolated chromaffin granules.
Iterative RELIEF for Feature Weighting: Algorithms, Theories, and Applications (2007)

RELIEF is considered one of the most successful algorithms for assessing the quality of features. In this paper, we propose a set of new feature weighting algorithms that perform significantly better than RELIEF, without introducing a large increase in computational complexity. Our work starts from a mathematical interpretation of the seemingly heuristic RELIEF algorithm as an online method solving a convex optimization problem with a margin-based objective function. This interpretation explains the success of RELIEF in real application and enables us to identify and address its following weaknesses. RELIEF makes an implicit assumption that the nearest neighbors found in the original feature space are the ones in the weighted space and RELIEF lacks a mechanism to deal with outlier data. We propose an iterative RELIEF (I-RELIEF) algorithm to alleviate the deficiencies of RELIEF by exploring the framework of the expectation-maximization algorithm. We extend I-RELIEF to multiclass settings by using a new multiclass margin definition. To reduce computational costs, an online learning algorithm is also developed. Convergence analysis of the proposed algorithms is presented. The results of large-scale experiments on the UCI and microarray data sets are reported, which demonstrate the effectiveness of the proposed algorithms, and verify the presented theoretical results
Die Farbe der „Fulgensäuren” und „Fulgide”. (7. Abhandlung über Butadiënverbindungen.) (1905)

besteht : 1 .der Bildung von Magnesiumhalogenalkylen und 2. der Urnwandelung dieser Verbindungen in ihre Aethercomplexe.. Die erhalteiien Resultate beweisen,
Rapid in vitro detection of CTX-M groups 1, 2, 8, 9 resistance genes by LAMP assays (2018)

Being sensitive, specific, rapid and standard methods, the LAMP assays developed in this study have a potential to be beneficial tools in molecular epidemiology and surveillance studies of the four prevalent EBSLs CTX-M groups even in low cost laboratory.
From Scatterbrained to Focused: UI Support for Today's Crazed Information Worker (2006)

Today's information workers are characterized by their ability to easily handle interruptions, multi-task, switch tasks quickly, and make sense of enormous amounts of information in high-pressure situations. Current and future technologies, including various wearables and sensing devices, ensure that robust communications and information transmissions can occur almost anywhere, any time. Our ability to log, collect, and visualize event data has become more sophisticated, allowing us to analyze trends and identify patterns across many areas of individual and group behaviors. How do we use these technological trends to ensure that we are designing tools that improve productivity, insight, and an overall sense of user control? In this paper, I discuss our research approach to the usercentered design of advanced user interfaces, and describe a few of our research projects.
Microstrip slow-wave open-loop resonator filters (2002)

Microstrip slow-wave open-loop resonators allow various filter configurations including those of elliptic or quasi-elliptic function response to be realised. The filters are not only compact in size due to the slow-wave effect, but also have a wider upper stopband resulting from the dispersion effects. These attractive features mean the microstrip slow-wave open-loop resonator filters hold promise for mobile communications, superconducting and other applications.
Raman spectroscopy of supported chromium oxide catalysts. Determination of chromium—oxygen bond distances and bond orders (1996)

An empirical correlation is described for relating Raman stretching frequencies of chromium—oxygen (Cr—O) bonds to their bond lengths in chromium oxide reference compounds. An exponential fit of crystallographically determined Cr—O bond lengths to Cr—O Raman symmetric stretching frequencies (800–1300 cm–1) is presented along with a relation between Cr—O bond strengths and Raman stretching frequencies. These empirical correlations have led to a systematic method for determining the coordination and bond lengths of chromates. The developed method is illustrated for chromates with unknown local structure in Bi2O3· K2CrO4 sillenite and for different supported chromium oxide catalysts. The obtained results are compared with those previously obtained by X-ray absorption spectroscopy.
A Private Data Transfer Protocol Based On A New High Secure Computer Architecture (2012)

Focusing on the characteristics of the new high secure architecture of network computer, an operating system with internal network structure is designed. The operating system contains two subkernels: local kernel and network kernel, the two subkernels run individually in two subsystems. In order to communicate between two subsystems securely, an inter-subsystem private data transfer protocol is proposed and implemented in this paper. The private protocol is a connection-oriented protocol, it can provide reliable end-to-end connectivity Protocol format and protocol connection management based on signature verification are elaborated. Combining with shared transit cache which mounted on the shared bus, the private data transfer protocol can ensure data to be transferred safely and inerrably between subsystems. The effectiveness of the private data transfer protocol is verified by the results of final experiments.
Nitric Oxide, Stress, and Depression (2025)

Stress and depression have a significant impact on modern society. Even though their symptomatology is well characterized, little is known about the molecular mechanisms underlying these disturbing disorders. While the role of neurotransmitters such as serotonin, norepinephrine (NE), dopamine (DA), corticotropin-releasing hormone (CRH), and arginine vasopressin (AVP) has been extensively studied, new evidence suggests a role for the unique neurotransmitter nitric oxide (NO). This highly diffusible and reactive molecule is synthesized by at least three enzyme subtypes of NO synthase (NOS). The commonly known neuronal NOS subtype is localized in areas of the brain related to stress and depression. The limbic-hypothalamic-pituitary-adrenal (LHPA) axis is the core of this system. These interrelated pathways have in common the production, and negative feedback, of glucocorticoids. Within these areas, NO is suggested to play a role in modulating the release of other neurotransmitters, acting as a cellular communicator in plasticity and development, and/or acting as a vasodilator in regulation of blood flow. This article summarizes some of the recent advances in the understanding of the role of NO in stress and depression.
Reciprocal role of cyclins and cyclin kinase inhibitor p21WAF1/CIP1 on lymphocyte proliferation, allo-immune activation and inflammation (2005)

Cyclins play a significant role in transplant-induced immune activation and p21 over-expression has potential to inhibit T cell activation and inflammation. The results from this study will permit the design of alternate strategies by controlling cell cycle progression to achieve immunosuppression in transplantation.
High performance ultrafast fiber laser systems (2005)

We will review the achievements, the scaling potential and applications of high average power and high energy ultrafast ytterbium-doped fiber laser systems
A first-line, phase II study with dacarbazine (DTIC) plus thymosin alpha 1 (Ta1) with or without interferon alpha (IFNa) vs. DTIC plus IFNa in stage IV melanoma (2006)

Mackiewicz, A.; Testori, A.; Ferraresi, V.; Maio, M.; Garbe, C.; Guillot, B.; Gascon, P.; Gilde, K.; Camerini, R.; Cognetti, F. Author Information
Thermally induced optical bistability in thin film devices (1985)

A simple theoretical model describing thermally induced optical bistability is discussed. Results of experimental studies of optical bistability in ZnSe interference filters near the band edge are in good agreement with the predictions of this model.
A Highly Active Ylide‐Functionalized Phosphine for Palladium‐Catalyzed Aminations of Aryl Chlorides (2018)

Ylide-functionalized phosphine ligands (YPhos) were rationally designed to fit the requirements of Buchwald-Hartwig aminations at room temperature. This ligand class combines a strong electron-donating ability comparable to NHC ligands with high steric demand similar to biaryl phosphines. The active Pd species are stabilized by agostic C-H⋅⋅⋅Pd rather than by Pd-arene interactions. The practical advantage of YPhos ligands arises from their easy and scalable synthesis from widely available, inexpensive starting materials. Benchmark studies showed that YPhos-Pd complexes are superior to the best-known phosphine ligands in room-temperature aminations of aryl chlorides. The utility of the catalysts was demonstrated by the synthesis of various arylamines in high yields within short reaction times.