gebhart/patrepeval huggingface dataset:
Fast Ray-Axis Aligned Bounding Box Overlap Tests with Plucker Coordinates (2004)

Abstract Fast ray-axis aligned bounding box overlap tests can be performed by utilizing Pliicker coordinates. This method tests the ray against the edges comprising the silhouette of the box instead of testing against individual faces. Projection of the edges onto a two-dimensional plane to generate the silhouette is not necessary, which simplifies the technique. The method is division-free and successive calculations are independent and consist simply of dot product operations, which permits vectorization. The method does not compute an intersection distance along the ray to the box, but this can be added as an additional step. Storage of Pliicker coordinates is unnecessary, permitting integration into existing systems. Test results show the technique's performance is up to 93% faster than traditional methods if an intersection distance is not needed.
[Quadriceps myopathy as dystrophin-associated myopathy]. (1993)

Duchenne and Becker muscular dystrophy are both caused by a deletion in the dystrophin gene. In the past few years, many reports of atypical myopathies have been published where an association with a deletion within the same gene was found. We report one sporadic and one familial case of myopathy where we were able to demonstrate a deletion of the dystrophin locus using DNA analysis.
Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1 (2010)

Epstein-Barr virus (EBV) is associated with human malignancies, especially those affecting the B cell compartment such as Burkitt lymphoma. The virally encoded homolog of the mammalian pro-survival protein Bcl-2, BHRF1 contributes to viral infectivity and lymphomagenesis. In addition to the pro-apoptotic BH3-only protein Bim, its key target in lymphoid cells, BHRF1 also binds a selective sub-set of pro-apoptotic proteins (Bid, Puma, Bak) expressed by host cells. A consequence of BHRF1 expression is marked resistance to a range of cytotoxic agents and in particular, we show that its expression renders a mouse model of Burkitt lymphoma untreatable. As current small organic antagonists of Bcl-2 do not target BHRF1, the structures of it in complex with Bim or Bak shown here will be useful to guide efforts to target BHRF1 in EBV-associated malignancies, which are usually associated with poor clinical outcomes.
Special Articles on Organic and Inorganic Optical Materials. A New Type Monolayered Organic Photoconductor for Positive Charging Xerography. Chemistry and Characteristics. (1992)

今回,著者らが開発した電子写真用正帯電単層有機感光体(以下正帯電単層OPC:organicphoto-conductorと略)は,従来のセレン系感光体,あるいは負帯電積層有機感光体にはない種々の優れた特性を有するとともに,有機高分子材料の優れたフレキシビリティーと成形性を兼ね備え,かつエコロジーに対応した機能性有機電子材料デバイスである。本正帯電単層OPCは,電荷発生材料としてベリレン系顔料,電荷輸送材料としてヒドラゾン誘導体,ヒドラゾン誘導体の光励起一重項エネルギー失活剤としてのフルオレン誘導体等の組成物からなり,優れた電子写真感度,安定性および寿命をもつ。本報では,正帯電単層OPCの技術について,化学的側面を中心に材料設計の考え方や感光体の諸特性などを含め総合的に報告する。
A fully autonomous docking strategy for Intervention AUVs (2007)

The development of effective control architectures for Intervention AUVs (I-AUV) is a very challenging task due to the inherent complexities of the environment and the necessity of the vehicle to come into contact with underwater structures without closed-loop supervision. Despite this, both the scientific and industrial communities are keen supporters of the development of I-AUV technology owing to the relevant cost saving opportunities they are potentially able to offer in a number of applications. In this article we describe a comprehensive control architecture designed to dock an I-AUV on a receiving structure, using sonar and video image processing alongside navigation data from conventional sensors. The approach is based on custom developed sonar and video processing algorithms and the results are validated in real-time conditions by means of Ifremer's experimental underwater vehicle VORTEX.
A Randomised, Placebo-Controlled, Crossover Study Investigating the Effects of Nicotine Gum on Strength, Power and Anaerobic Performance in Nicotine-Naïve, Active Males (2017)

Chewing low-dose (2 mg) nicotine gum 20 min prior to exercise significantly improved leg extensor torque but did not affect counter-movement jump height or Wingate performance compared to a placebo, whilst there were minimal effects of the 4 mg nicotine gum on the performance parameters measured.
Salmonella Contamination in a Commercial Poultry (Broiler) Processing Operation , (1974)

The results of these studies indicate that the number of broiler chickens entering a processing plant that harbor Salmonella is generally low. In the processing operation, mechanical spread of the Salmonella organisms apparently readily occurs so that as much as 90% of the dressed product is contaminated with Salmonella organisms. A limited number of carcasses from the same processing plant but examined at the retail level were all found to be contaminated with Salmonella. The use of chlorine dioxide (ClO2) at levels of less than 8 p.p.m. in the processing plant chill water did not reduce the levels of Salmonella or the number of bacteria on the surface of processed chicken carcasses. Similarly, laboratory studies utilizing chicken skins revealed no effect by ClO2 on the test organism, S. typhimurium.
Writer Identification from Non-uniformly Skewed Handwriting Images (1998)

Many techniques have been reported for handwriting-based writer identification. Most such techniques assume that the written text is fixed (e.g., in signature verification). In this paper we attempt to eliminate this assumption by presenting a novel algorithm for automatic text-independent writer identification from non-uniformly skewed handwriting images. Given that the handwriting of different people is often visually distinctive, we take a global approach based on texture analysis, where each writers’ handwriting is regarded as a different texture. In principle this allows us to apply any standard texture recognition algorithm for the task (e.g., the multi-channel Gabor filtering technique). Results of 96.0% accuracy on the classification of 150 test documents from 10 writers are very promising. The method is shown to be robust to noise and contents.
Interleukin-13 as an important cytokine: A review on its roles in some human diseases (2015)

Interleukin-13 (IL-13) as a pleiotropic cytokine acts through the IL-13Ra1/IL-4Ra complex to induce activation responses which contribute to the inflammatory diseases. Genetic polymorphisms in IL-13 and its receptor components have been proved to be associated with higher disease prevalence rates. Animal models such as in IL-13 deficient mice and transgenic animals also have been confirmed the critical role of this cytokine in the immune responses, mostly by IL-13 neutralization and IL-13/IL-4 dual neutralization strategies. This review highlights IL-13 structure as well as its pivotal roles in the normal physiologic and pathologic states. It is followed by a section on the recent findings on IL-13 receptors and signalling mechanisms to briefly summarize its functions in the immune systems. IL-13 roles in the human diseases such as asthma, systematic sclerosis, and some inflammatory diseases are described concisely. Finally some of the ongoing therapeutic applications are presented to comprehensively review IL-13 mediator roles.
Looking inside the (drop) box (2013)

Dropbox is a cloud based file storage service used by more than 100 million users. In spite of its widespread popularity, we believe that Dropbox as a platform hasn’t been analyzed extensively enough from a security stand-point. Also, the previous work on the security analysis of Dropbox has been heavily censored. Moreover, the exist-ing Python bytecode reversing techniques are not enough for reversing hardened applications like Dropbox. This paper presents new and generic techniques, to re-verse engineer frozen Python applications, which are not limited to just the Dropbox world. We describe a method to bypass Dropbox’s two factor authentication and hijack Dropbox accounts. Additionally, generic techniques to intercept SSL data using code injection techniques and monkey patching are presented. We believe that our biggest contribution is to open up the Dropbox platform to further security analysis and re-search. Dropbox will / should no longer be a black box. Finally, we describe the design and implementation of an open-source version of Dropbox client (and yes, it runs on ARM too). 1
Toll-like receptors as targets in chronic liver diseases (2009)

Toll-like receptors (TLRs) recognise pathogen-associated molecular patterns (PAMPs) to detect the presence of pathogens. In addition to their role in innate immunity, TLRs also play a major role in the regulation of inflammation, even under sterile conditions such as injury and wound healing. This involvement has been suggested to depend, at least in part, on the ability of TLRs to recognise several endogenous TLR ligands termed damage-associated molecular patterns (DAMPs). The liver not only represents a major target of bacterial PAMPs in many disease states but also upregulates several DAMPs following injury. Accordingly, TLR-mediated signals have been implicated in a number of chronic liver diseases. Here, we will summarise recent findings on the role TLRs and TLR ligands in the pathophysiology of liver fibrosis and cirrhosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease and hepatocellular carcinoma, and highlight the potential role of TLR agonists, antagonists and probiotics for the treatment of chronic liver disease.
Forecast Model of TV Show Rating Based on Convolutional Neural Network (2021)

The TV show rating analysis and prediction system can collect and transmit information more quickly and quickly upload the information to the database. The convolutional neural network is a multilayer neural network structure that simulates the operating mechanism of biological vision systems. It is a neural network composed of multiple convolutional layers and downsampling layers sequentially connected. It can obtain useful feature descriptions from original data and is an effective method to extract features from data. At present, convolutional neural networks have become a research hotspot in speech recognition, image recognition and classification, natural language processing, and other fields and have been widely and successfully applied in these fields. Therefore, this paper introduces the convolutional neural network structure to predict the TV program rating data. First, it briefly introduces artificial neural networks and deep learning methods and focuses on the algorithm principles of convolutional neural networks and support vector machines. Then, we improve the convolutional neural network to fit the TV program rating data and finally apply the two prediction models to the TV program rating data prediction. We improve the convolutional neural network TV program rating prediction model and combine the advantages of the convolutional neural network to extract effective features and good classification and prediction capabilities to improve the prediction accuracy. Through simulation comparison, we verify the feasibility and effectiveness of the TV program rating prediction model given in this article.
Regioselective synthesis using the deuterium isotope effect (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegioselective synthesis using the deuterium isotope effectMasateru MiyanoCite this: J. Org. Chem. 1981, 46, 9, 1854–1857Publication Date (Print):April 1, 1981Publication History Published online1 May 2002Published inissue 1 April 1981https://pubs.acs.org/doi/10.1021/jo00322a022https://doi.org/10.1021/jo00322a022research-articleACS PublicationsRequest reuse permissionsArticle Views118Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimizing Web services performance by differential deserialization (2005)

Web services technology has emerged as a key infrastructure that enables business entities to interact with each other without any human inventions. In order for the technology to be widely used, especially in any field where a large volume of transactions may be processed, it is highly desirable that the Web services engine should tolerate such environments. In this paper, we present a novel approach for improving Web services performance. We first focus on the fundamental characteristics of the Web services in that the SOAP messages on the wire are mostly generated by machines and have a lot of similarities among the processed messages. By making use of these features and eliminating the redundant processing, we propose a new deserialization mechanism that reuses matching regions from the previously deserialized application objects from earlier messages, and only performs deserialization for a new region that would not be processed before. Through our experiments in this paper, we observed that our approach obtained a 288% performance gain (maximum) by incorporating the differential deserialization into the Axis SOAP engine.
Suppression of time-varying resonances in the power supply line of AC locomotives by inverter control (1992)

The harmonic currents generated by the line-side converter of an electric locomotive are injected into the overhead supply system. Although low in magnitude, they give rise to traveling waves that start propagating in both directions along the overhead line. The traveling waves are reflected at various electrical discontinuities along the line such as the feeding substations and other traction vehicles, the positions of which are time varying. This produces eigenresonances at multiple frequencies. High resonant currents may be generated that cause problems of electromagnetic interference with railway communication and signaling systems. It is demonstrated that the time-varying eigenresonances can be identified in real time. Methods of optimal adaptive inverter control are employed in order to avoid the excitation of the line resonances.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The acquired immune deficiency syndrome (AIDS): current status and implications for respiratory care practitioners. (1984)

The acquired immune deficiency syndrome (AIDS) has affected more than 2,600 persons since 1981, with the number of reported cases rising exponentially. The disease is characterized by a deficiency in the cell-mediated immune system, which allows entrance to a host of opportunistic infections as well as tumors. The most common infection associated with AIDS is Pneumocystis carinii pneumonia, a previously uncommon infection of immunocompromised hosts. The most common neoplasm associated with AIDS is an otherwise rare skin tumor, Kaposi's sarcoma. AIDS is most often seen in homosexuals and intravenous-drug abusers, but the spectrum of the disease is widening and now includes other high-risk groups. The pulmonary manifestations of AIDS range from a nonproductive cough to acute respiratory failure. Once hospitalized, the AIDS patient may require several diagnostic and therapeutic services from respiratory care personnel. We review the epidemiology of this new syndrome, provide the basic framework for an understanding of the immunologic dysfunction in AIDS victims, review the clinical manifestations, and discuss the implications of the communicability of AIDS for the respiratory care practitioner.
Ultrasonography in Developmental Hip Dysplasia (1995)

With the evolving use of ultrasonography, there has been an increasing emphasis on the technically oriented diagnosis of developmental hip dysplasia. Graf's alpha and beta angles and Harcke's bony rim percentage are two of the more common criteria, but their repeatability and reliability have not been well documented. Fifty-eight hip ultrasounds of 29 infants were measured independently by three physicians, and statistical analysis was performed. It was concluded that Graf's and Harcke's methods could be repeatable with training and frequent use of ultrasonography. Harcke's guidelines have a large equivocal zone, which limited their clinical usefulness. Graf's angles gave a better classification, but their clinical relevance has not been proven.
Hematopoietic stem cells from pluripotent stem cells: Clinical potential, challenges, and future perspectives (2020)

The generation of hematopoietic stem cells (HSCs) from induced pluripotent stem cells (iPSCs) is an active and promising area of research; however, generating engraftable HSCs remains a major obstacle. Ex vivo HSC derivation from renewable sources such as iPSCs offers an experimental tool for studying developmental hematopoiesis, disease modeling, and drug discovery, and yields tremendous therapeutic potential for malignant and nonmalignant hematological disorders. Although initial attempts mostly recapitulated yolk sac primitive/definitive hematopoiesis with inability to engraft, recent advances suggest the feasibility of engraftable HSC derivation from iPSCs utilizing ectopic transcription factor expression. Strategic development for de novo HSC generation includes further investigations of HSC ontogeny, and elucidation of critical signaling pathways, epigenetic modulations, HSC and iPSC microenvironment, and cell-cell interactions that contribute to stem cell biology and function.
Underreporting of Dengue-4 in Brazil Due to Low Sensitivity of the NS1 Ag Test in Routine Control Programs (2013)

We have identified fifty-eight samples that were positive for Dengue-4 among 119 samples with negative diagnoses for dengue via the Platelia™ dengue NS1 Ag in Aracaju, State of Sergipe, Brazil. We determined that the low sensitivity of the NS1 Ag test could be related to secondary dengue infections in the studied population. Therefore, we concluded that the sensitivity and specificity of the Platelia™ dengue NS1 Ag test as a screening method for monitoring circulating dengue serotypes must be reevaluated. In addition, regional endo-epidemic profiles should also be considered due to the prevalence of secondary responses.
A low-cost observatory tape recorder (1973)

abstract A new principle of recording earthquakes on magnetic tape by triggering is described. Utilizing the multiplex FM system, an ordinary tape recorder is run both as memory and as storage equipment. The recorder runs normally forward during a cycle of about 10 min. If no earthquake has triggered the system, the tape is rewound to its initial position; but if a seismic pulse surpasses the trigger level, the “rewind” function of the recorder is postponed, and every time this level is surpassed, a new period of postponement begins. Thus, a continuous and complete record of an earthquake is obtained.
Carnosine as a potential anti-senescence drug. (2000)

The naturally occurring dipeptide carnosine (beta-alanyl-L-histidine) has been found to exert an anti-senescence effect when used as a dietary supplement. Carnosine clearly improved the external appearance of experimental animals and provided beneficial physiological effects, thus maintaining the animals in better condition than control animals receiving no carnosine or a mixture of beta-alanine and L-histidine.
Peripheral Nerve Reconstruction after Injury: A Review of Clinical and Experimental Therapies (2014)

Unlike other tissues in the body, peripheral nerve regeneration is slow and usually incomplete. Less than half of patients who undergo nerve repair after injury regain good to excellent motor or sensory function and current surgical techniques are similar to those described by Sunderland more than 60 years ago. Our increasing knowledge about nerve physiology and regeneration far outweighs our surgical abilities to reconstruct damaged nerves and successfully regenerate motor and sensory function. It is technically possible to reconstruct nerves at the fascicular level but not at the level of individual axons. Recent surgical options including nerve transfers demonstrate promise in improving outcomes for proximal nerve injuries and experimental molecular and bioengineering strategies are being developed to overcome biological roadblocks limiting patient recovery.
HLA antibodies in haematopoietic stem cell transplantation (2019)

The negative impact of donor specific HLA alloantibodies in solid organ transplantation is well known and understood within the histocompatibility and immunogenetics community. However the influence of donor-specific antibodies in the outcome of haematopoietic stem cell transplantation is less well regarded. As donor choices have evolved from HLA matched siblings and extremely well matched unrelated donors to mismatched cord blood and haplo-identical-related donors, we are now identifying more patients with antibodies reactive against their donor mismatches. The clinical significance of the antibodies that can be detected has not yet been fully elucidated.
Skin permeability and pharmacokinetics of diclofenac epolamine administered by dermal patch in Yorkshire-Landrace pigs (2012)

Dermal patch application resulted in low systemic absorption and high tissue penetration of diclofenac compared with oral administration.
The effect of low intensity pulsed ultrasound applied to rabbit tibiae during the consolidation phase of distraction osteogenesis (2002)

The purpose of this study was to determine if low intensity pulsed ultrasound (LIPU) accelerated the maturation of regenerate bone when applied after distraction in a rabbit model. A mid-tibial osteotomy was performed in 26 New Zealand white rabbits and an external fixator applied anteromedially. After a seven day latency period, the tibiae were distracted 0.5 mm every 12 h for 10 days. Thirteen of the rabbits received LIPU for 20 min/day (treatment group) and 13 received sham LIPU (control group) from day 17 until sacrifice on day 37. Radiographs were taken weekly after distraction and the total and mineralized areas of the callus were measured. After sacrifice, dual-energy X-ray absorptiometry, torsional testing to failure, and histomorphometry were performed. Ultrasound-treated tibiae were a mean of 68.8 +/- 3.8% as stiff as and 68.2 +/- 6.0% as strong as the contralateral tibiae. Control tibiae were 78.7 +/- 7.0%, as stiff as and 70.2 +/- 7.9% as strong as the contralateral tibiae. The differences in stiffness and strength were not significant (p = 0.39 and 0.81, respectively) with the number of the animals tested in the study. The treatment group was 91.6% as dense as the contralateral side and the control group was 88.5% as dense as the contralateral side (p = 0.84). Radiographs revealed a significantly larger callus in the LIPU-treated tibiae at 1, 2 and 3 weeks after distraction compared to control tibiae (p < 0.01, 0.008 and 0.05, respectively). Histomorphometry revealed significantly less fibrous tissue in the LIPU-treated tibiae (p < 0.05) and a strong trend towards more bone in the LIPU-treated tibiae compared to controls (p = 0.06). LIPU was found to increase the size of the distraction callus and it might alter the composition of regenerate bone but it did not have a positive effect on the mechanical properties or density of regenerate bone when applied during the consolidation phase of distraction osteogenesis.