gebhart/patrepeval huggingface dataset:
DIRECTIONAL DECONVOLUTION OF MARINE SEISMIC REFLECTION DATA: NORTH SEA EXAMPLE<sup>1</sup> (1990)

A bstract Directional deconvolution of the signature from a marine seismic source array may be achieved in combination with prestack migration or dip moveout (DMO) processing. The benefit is demonstrated using an example profile from the southern North Sea. In particular, shallow, dipping reflectors have improved continuity and frequency content. The method could be extended to 3D data to remove both in‐line and cross‐line directivity effects.
SPICE modeling of hybrid multi-frequency ultrasound transducer (2011)

Whereas ultrasound application has been emerging, the need of reliable transducer to comply with that purpose is also aroused. Multi-resonance transducer using lead zirconate titanate piezoelectric ceramics (PZT) was designed several years ago for dual Doppler and B mode use. As polymer material being popular in medical ultrasound, there are chances to combine it with former piezoelectric material in designing diagnostic transducer to get hybrid characteristics required for multi-frequency application. In this work, SPICE model of ceramic-polymer piezoelectric has been described. Using Leach's approach, the modeled transducer covers triple peaks resonances. Electro-acoustic circuit simulation level shows that by hybridization, characteristics of both materials are providing a satisfying performance for multi-frequency transducer.
Session 3: Second Messengers in the Gastric Gland: A Focus on Calcium (1991)

The rabbit gastric gland model was used to study the nature of the muscarinic cholinergic and gastrin responses of parietal cells. Carbachol (100 microM) stimulation of acid secretion, as measured by the accumulation of aminopyrine, was inhibited by the M1 antagonist pirenzepine with an IC50 of 13 microM; by the M2 antagonist 11,2-(diethylamino)methyl-1-piperidinyl acetyl-5,11-dihydro-6H-pyrido 2,3-b 1,4-benzodiazepin-6-one (AF-DX 116) with an IC50 of 110 microM; and by the M3 antagonist diphenylacetoxy-4-methylpiperidinemethiodide (4-DAMP) with an IC50 of 35nM. The three antagonists displayed similar IC50 values for the inhibition of carbachol-stimulated production of 14CO2 from radiolabeled glucose, which is a measure of the turnover of the H(+)-H(+)-ATPase. Intracellular calcium levels wer measured in gastric glands loaded with FURA2. Carbachol was shown both to release calcium from an intracellular pool and to promote calcium entry across the plasma membrane. The calcium entry was inhibitable by 20 microM La3+. The relative potency of the three muscarinic antagonists for inhibition of calcium entry was essentially the same as for inhibition of acid secretion or metabolism. However, the rise in cell calcium due to release of calcium from intracellular stores was inhibited by 4-DAMP with an IC50 of 1.7 nM. Image analysis confirmed that the effect of carbachol and of the antagonists on intracellular calcium was occurring in the partial cell. In particular, the high-affinity inhibition of calcium release by 4-DAMP occurs in the parietal cell. Accordingly, it appears that the secretory receptor of the parietal cell is of the M3 type, and acid secretion depends on the entry of calcium rather than on calcium release from intracellular stores. In parallel experiments gastrin (G-17-sulfated) produced a dose-dependent increase in intracellular calcium (EC50, 0.14 +/- 0.013 microM). No stimulation of acid secretion was observed, but pepsinogen secretion was stimulated dose-dependently (EC50 = 1.17 +/- 0.21 microM).
Magnetic Carbon Nanotubes:  Synthesis by Electrostatic Self-Assembly Approach and Application in Biomanipulations (2006)

Magnetic multiwalled carbon nanotubes (MWNTs) were facilely prepared by the electrostatic self-assembly approach. Poly(2-diethylaminoethyl methacrylate) (PDEAEMA) was covalently grafted onto the surfaces of MWNTs by MWNT-initiated in situ atom transfer radical polymerization (ATRP) of 2-diethylaminoethyl methacrylate (DEAEMA). The PDEAEMA-grafted MWNTs were quaternized with methyl iodide (CH(3)I), resulting in cationic polyelectrolyte-grafted MWNTs (MWNT-PAmI). Magnetic iron oxide (Fe(3)O(4)) nanoparticles were loaded onto the MWNT surfaces by electrostatic self-assembling between MWNT-PAmI and Fe(3)O(4), affording magnetic nanotubes. The assembled capability of the nanoparticles can be adjusted to some extent by changing the feed ratio of Fe(3)O(4) to MWNT-PAmI. The obtained magnetic nanotubes were characterized with TEM, EDS, STEM, and element mapping analyses. TEM and EDS measurements confirmed the nanostructures and the components of the resulting nanoobjects. The magnetic nanotubes were assembled onto sheep red blood cells in a phosphate buffer solution, forming magnetic cells. The blood cells attached with or without magnetic nanotubes can be selectively manipulated in a magnetic field. These results promise a general and efficient strategy to magnetic nanotubes and the fascinating potential of such magnetic nanoobjects in applications of bionanoscience and technology.
Mechanical bowel preparation versus no preparation in elective colorectal surgery: A prospective randomized study (2016)

ABSTRACT Background: Mechanical bowel preparation (MBP) of gut is routinely done before colorectal surgeries in most surgical departments all over the globe. This gut preparation is aimed at reducing the risk of postoperative infections in patients undergoing colorectal surgery. Even though recent studies are more in favor of operating on gut without bowel preparation, controversies still exist. The aim of our study was to assess whether elective colorectal surgeries can be performed safely without preoperative MBP. Methods: Patients undergoing elective colorectal surgeries were prospectively randomized into two groups with the help of random number table method; Group-1 had mechanical bowel preparation with polyethylene glycol (MBP group) before surgery, and Group-2 had no mechanical bowel preparation (NMBP group) before surgery. All patients in the study groups were followed up for at least 2 months after surgery for wound infection, anastomotic leak and intra-abdominal infections. Results: Two hundred fourteen patients were included in this hospital-based systematic prospective randomized trial: 104 patients in Group-1 and 98 patients in Group-2. Twelve patients were excluded from the study. The type of surgical procedure and type of anastomosis did not significantly differ between two groups. There was no difference in surgical infections between two groups. The overall infection rate was 39.4% in Group-1 and 32.6% in Group-2 (p = 0.31). Wound infection (p = 0.45), anastomotic leak (p = 0.45) and intra-abdominal/pelvic collection (p = 0.62) occurred in 3.8%, 3.8% and 6.7% versus 6.1%, 2% and 5.1% in Group-1 (MBP group) and Group-2 (NMBP group) respectively. Our results showed that MBP does not offer any specific benefit in elective colorectal surgeries but in real sense may add to some problems, which, however, did not achieve a statistical significance. Conclusions: Our study proved that no advantage is gained by pre-operative mechanical bowel preparation in elective colorectal surgery and can be easily avoided in order to save patients from unwanted exhaustion, distress and adverse effects related to it. It is actually the mindset that makes us to believe that MBP will reduce the incidence of infections rather than the evidence from literature. We conclude from our study that all types of elective colorectal surgeries can be performed safely without subjecting patients to mechanical bowel preparation before surgery. Highlights:
Detecting and preventing adverse drug interactions: The potential contribution of computers in pharmacies (1986)

For patients taking two or more medications concurrently, interactions among the drugs can cause undesirable effects or negate desired responses. In modern pharmacy practice, an important role of the pharmacist is to detect potentially harmful interactions and take appropriate action to prevent their occurrence. Pharmacy computer systems offer potential for improving pharmacists' effectiveness in the detection and followup of drug interactions. Based on a survey of southern Michigan pharmacists, relationships between computer use and pharmacists' attitudes and activities in drug interaction monitoring were investigated. Respondents included users of two major computer systems as well as pharmacists who do not use computers. Results suggest that general statements cannot be made about the effect of computer use on drug interaction detection. Users of one of the two computer systems detected and followed up on interactions more frequently and were more likely to report improved knowledge of drug interactions than non-users. Frequencies of drug interaction detection and other related measures reported by users of the second computer system were similar to those for pharmacists not using computers. Computer system characteristics which might lead to these differences are discussed.
Automated W-CDMA microcellular deployment and coverage reconfiguration based on situation awareness (2003)

This paper examines the implementation of an automated W-CDMA microcellular deployment and coverage reconfiguration algorithm based on the concepts of situation awareness (SA). A deterministic microcellular propagation model (Citrus) is used to provide the detailed site-specific propagation data. An initial network deployment is performed over one square kilometre of central Bristol using the combination algorithm for total optimisation (CAT). Buildings are then added or removed from the microcell to represent realistic time variations in the geographic environment. A new situation awareness (SA) algorithm is developed and applied to the modified W-CDMA microcell to automatically reconfigure the network's coverage and capacity based on the new propagation environment. Optimisation of coverage and capacity is achieved through the use of a genetic algorithm (GA). This paper presents the details of the underlying SA algorithm and the results obtained for the above scenario. These new algorithms are shown to automatically sustain a high grade of service as the microcellular environment evolves over time. Gains of up 203% in spectral efficiency were observed for the 144 kbps service.
Inhibitors of Catalase-Amyloid Interactions Protect Cells from β-Amyloid-Induced Oxidative Stress and Toxicity (2010)

Compelling evidence shows a strong correlation between accumulation of neurotoxic β-amyloid (Aβ) peptides and oxidative stress in the brains of patients afflicted with Alzheimer disease (AD). One hypothesis for this correlation involves the direct and harmful interaction of aggregated Aβ peptides with enzymes responsible for maintaining normal, cellular levels of reactive oxygen species (ROS). Identification of specific, destructive interactions of Aβ peptides with cellular anti-oxidant enzymes would represent an important step toward understanding the pathogenicity of Aβ peptides in AD. This report demonstrates that exposure of human neuroblastoma cells to cytotoxic preparations of aggregated Aβ peptides results in significant intracellular co-localization of Aβ with catalase, an anti-oxidant enzyme responsible for catalyzing the degradation of the ROS intermediate hydrogen peroxide (H(2)O(2)). These catalase-Aβ interactions deactivate catalase, resulting in increased cellular levels of H(2)O(2). Furthermore, small molecule inhibitors of catalase-amyloid interactions protect the hydrogen peroxide-degrading activity of catalase in Aβ-rich environments, leading to reduction of the co-localization of catalase and Aβ in cells, inhibition of Aβ-induced increases in cellular levels of H(2)O(2), and reduction of the toxicity of Aβ peptides. These studies, thus, provide evidence for the important role of intracellular catalase-amyloid interactions in Aβ-induced oxidative stress and propose a novel molecular strategy to inhibit such harmful interactions in AD.
New self-bonding wire for deflection yoke coil (2003)

The deflection yoke (DY) coil, which is used in the CRT (cathode ray tube), has to be manufactured exactly as designed for CRT screen accuracy. In the production of the coil, conventional self-bonding wire was coated with polyamide resin because of its good bondability. But the deflection yoke coil with a polyamide self-bonding wire coat was difficult to manufacture as designed; therefore, the accuracy of the CRT screen could not be guaranteed. The authors describe a new self-bonding wire which has good bondability and little coil deformation. This wire has the following properties: the amount of coil deformation is not changed under high temperatures; near-perfect DY coils are manufactured; and the wire is solderable. The new self-bonding wire is expected to shorten the manufacturing process and to improve windability. It is concluded that this new self-bonding wire should be useful in improving the accuracy of the CRT screen.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Olefin Polymerization by Half-Titanocenes Containing η<sup>2</sup>-Pyrazolato Ligands−MAO Catalyst Systems (2011)

A series of half-titanocenes containing pyrazolato ligands, Cp′TiCl2(3,5-R2C3HN2) (1a−d, 2a−c, 3a−c) [Cp′ = Cp (1), Cp* (2), tert-BuC5H4 (tert-BuCp, 3); R = H (a), Me (b), iPr (c), Ph (d)], have been employed as the catalyst precursors for ethylene polymerization, syndiospecific styrene polymerization, and copolymerization of ethylene with 1-hexene, styrene, and norbornene (NBE) in the presence of MAO cocatalyst. The Cp* analogues, especially 2a,b, exhibited high catalytic activities for ethylene polymerization affording the polymer with unimodal molecular weight distributions, whereas the Cp analogue (especially 1b,c) and the tert-BuCp analogues (3a−c) exhibited high catalytic activities for syndiospecific styrene polymerization. The ethylene/styrene copolymerization using the tert-BuCp−diisopropyl analogue (3c) −MAO catalyst system proceeds in a living manner, irrespective of the styrene concentration employed (in toluene at 25 °C), and the same system exhibited relatively high catalytic activity for the ethylene/NBE copolymerization with highly efficient NBE incorporation.
Enantioselective epoxidation of trans-disubstituted alkenes by D2-symmetric chiral dioxoruthenium(VI) porphyrins (1999)

A series of D2-symmetric chiral trans-dioxoruthenium(VI) porphyrins can effect enantioselective epoxidation of trans-β-methylstyrene in up to 70% ee, and 76% ee is attained for the oxidation of cinnamyl chloride; the facial selection for the trans-alkenes epoxidation is explained by a ‘head-on approach’ model.
Roughness-enhanced electroluminescence from metal oxide silicon tunneling diodes (2000)

An approximate two-order increase in magnitude in electroluminescence was observed for the metal-oxide-silicon tunneling diodes with oxide grown at 900/spl deg/C, as compared to 1000/spl deg/C. The X-ray reflectivity revealed that the oxide grown at 900/spl deg/C has rougher interface than that grown at 1000/spl deg/C. The role of interface roughness can be understood in a model composed of phonons and interface roughness. An external quantum efficiency of /spl sim/10/sup -6/ was obtained using Al electrodes.
Comprehensive genetic dissection of the magnetosome gene island reveals the step-wise assembly of a prokaryotic organelle (2010)

Although membrane-bounded compartments are commonly considered a unique eukaryotic characteristic, many species of bacteria have organelles. Compartmentalization is well studied in eukaryotes; however, the molecular factors and processes leading to organelle formation in bacteria are poorly understood. We use the magnetosome compartments of magnetotactic bacteria as a model system to investigate organelle biogenesis in a prokaryotic system. The magnetosome is an invagination of the cell membrane that contains a specific set of proteins able to direct the synthesis of a nanometer-sized magnetite crystal. A well-conserved region called the magnetosome island (MAI) is known to be essential for magnetosome formation and contains most of the genes previously implicated in magnetosome formation. Here, we present a comprehensive functional analysis of the MAI genes in a magnetotactic bacterium, Magnetospirillum magneticum AMB-1. By characterizing MAI deletion mutants, we show that parts of its conserved core are not essential for magnetosome biogenesis and that nonconserved genes are important for crystal formation. Most importantly, we show that the mamAB gene cluster encodes for factors important for magnetosome membrane biogenesis, for targeting of proteins to this compartment and for several steps during magnetite production. Altogether, this genetic analysis defines the function of more than a dozen factors participating in magnetosome formation and shows that magnetosomes are assembled in a step-wise manner in which membrane biogenesis, magnetosome protein localization, and biomineralization are placed under discrete genetic control.
Wideband MIMO channel diagonalization in the time domain (2011)

Methods for spatially diagonalizing wideband multiple-input multiple-output channels using linear finite impulse response (FIR) filters are investigated. The PSVD approach by applying the PQRD-BC algorithm for approximate singular value decomposition (SVD) of polynomial matrices is compared to the approach of performing a set of conventional SVDs in the Discrete Fourier Transform (DFT) domain, in terms of complexity and approximation error. Reduced order filters, based on the DFT-SVDs, are then obtained by optimizing the phases of the filters. Applying the phase optimized filters as linear filters then forms a benchmark on the accuracy attainable for any PSVD factorization, for the given filter length. Simulations show that the DFT-SVD method has significantly lower complexity than the PSVD by PQRD-BC, but results in higher order filters. On the other hand, the PSVD by PQRD-BC yields filters which are close to being perfectly unitary for all frequencies. To achieve good performance, the reduced order filters are around one order of magnitude longer than the channel impulse response length. Therefore there is no gain in performing time domain diagonalization using a polynomial SVD, compared to using a multicarrier solution.
Collagen-coated microparticles in drug delivery (2009)

Advantages of drug-incorporated collagen particles have been described for the controlled delivery system for therapeutic actions. The attractiveness of collagen lies in its low immunogenicity and high biocompatibility. It is also recognized by the body as a natural constituent rather than a foreign body. Our research and development efforts are focused towards addressing some of the limitations of collagen, like the high viscosity of an aqueous phase, nondissolution in neutral pH buffers, thermal instability (denaturation) and biodegradability, to make it an ideal material for drug delivery with particular reference to microparticles. These limitations could be overcome by making collagen conjugates with other biomaterials or chemically modifying collagen monomer without affecting its triple helical conformation and maintaining its native properties. This article highlights collagen microparticles' present status as a carrier in drug delivery.
DNA-based intelligent logic controlled release systems (2012)

DNA assembles that can perform "OR" and "AND" logic gate operations were fabricated. The feasibility of intelligent logic controlled release was demonstrated through the controlled organization of gold nanoparticles on the surface of mesoporous silica by stimuli-induced structural transformation of DNA ensembles.
Efficient wound measurements using RGB and depth images (2015)

This paper presents a highly portable and a cost-effective non-invasive method of finding wound measurement information using depth image from Time-of-Flight (ToF) camera and RGB image from CMOS camera. The aim of paper is to contribute towards non-contact wound measurements, by employing a cheap and readily available RGB and depth sensors as a better alternative to manual wound measurement which is performed quite predominantly even today by most of the clinicians. The application provides the user with threefold information about the wound, its depth, area and volume which are computed and displayed automatically. The user can view these parameters within a minute of capturing the pictures of the wound along with a 3D wound image. The wound depth provided to the user can be used for judging the severity of the wound or for monitoring the healing of the wound. Furthermore, our proposed method for wound measurement can be useful not only in hospitals but also for wound assessment of patients living in remote areas or those unable to visit a doctor.
Plasmodium falciparum polypeptides released during in vitro cultivation. (1983)

Synchronous cultures of Plasmodium falciparum were successively labelled with ((35)S)-methionine and both the supernatants and the pellets of infected red blood cells were collected. The release of TCA-precipitable material in the culture supernatants was low during the development of ring forms and trophozoites, increased during schizogony, and was maximum at the time of schizont rupture and merozoite reinvasion. Analysis of the supernatants by SDS - PAGE and autoradiography showed that both polypeptides common to the various developmental stages of the parasite and schizont/merozoite-specific polypeptides were released. Polypeptides of relative molecular mass 140 000, 82 000 and, to a lower degree, 41 000 were present in high amounts in the culture supernatants. These polypeptides have been shown to be the target of monoclonal antibodies that are able to inhibit the growth of P. falciparum cultures, and may be involved in protective immunity. The released polypeptides may also be used as target antigens in immunodiagnostic tests aiming at the detection of malaria infection.
The RcsCDB Signaling System and Swarming Motility in<i>Salmonella enterica</i>Serovar Typhimurium: Dual Regulation of Flagellar and SPI-2 Virulence Genes (2007)

The Rcs phosphorelay is a multicomponent signaling system that positively regulates colanic acid synthesis and negatively regulates motility and virulence. We have exploited a spontaneously isolated mutant, IgaA(T191P), that is nearly maximally activated for the Rcs system to identify a vast set of genes that respond to the stimulation, and we report new regulatory properties of this signaling system in Salmonella enterica serovar Typhimurium. Microarray data show that the Rcs system normally functions as a positive regulator of SPI-2 and other genes important for the growth of Salmonella in macrophages, although when highly activated the system completely represses the SPI-1/SPI-2 virulence, flagellar, and fimbrial biogenesis pathways. The auxiliary protein RcsA, which works with RcsB to positively regulate colanic acid and other target genes, not only stimulates but also antagonizes the positive regulation of many genes in the igaA mutant. We show that RcsB represses motility through the RcsB box in the promoter region of the master operon flhDC and that RcsA is not required for this regulation. Curiously, RcsB selectively stimulates expression of the flagellar type 3 secretion genes fliPQR; an RcsAB box located downstream of fliR influences this regulation. We show that excess colanic acid impairs swimming and inhibits swarming motility, consistent with the inverse regulation of the two pathways by the Rcs system.