gebhart/patrepeval huggingface dataset:
PATHWAYS OF PROSTAGLANDIN F<sub>2α</sub> METABOLISM IN MAMMALIAN KIDNEYS (1977)

1 High-speed cytoplasmic supernatants of rat, rabbit, pig and guinea-pig kidneys were prepared and the metabolism of 10 mug/ml prostaglandin F(2alpha) labelled with [(3)H(1)-9beta]-prostaglandin F(2alpha) studied by thin layer radiochromatography and bioassay.2 The metabolism of prostaglandin F(2alpha) measured by radiochromatography parallels biological inactivation in all species except the rabbit.3 Kidneys metabolize prostaglandin F(2alpha) by two divergent pathways, yielding a mixture of prostaglandin E and F metabolites.4 15-Hydroxyprostaglandin dehydrogenase and prostaglandin Delta-13 reductase are present in all species in characteristic proportions. Thus prostaglandin F(2alpha) is metabolized sequentially to 15-keto prostaglandin F(2alpha) and 13,14-dihydro-15-keto prostaglandin F(2alpha). The rate and profile of formation of these metabolites is species-dependent.5 13,14-Dihydro-15-keto prostaglandin F(2alpha) is the principal prostaglandin F series metabolite in all species.6 Pig and guinea-pig kidney contain an unidentified enzyme which converts 13,14-dihydro-15-keto prostaglandin F(2alpha) to 13,14-dihydro prostaglandin F(2alpha).7 Rat kidney contains a high concentration of a prostaglandin 9-hydroxy dehydrogenase which converts 13,14-dihydro-15-keto prostaglandin F(2alpha) to 13,14-dihydro-15-keto prostaglandin E(2).8 Rabbit kidney contains a novel 9-hydroxydehydrogenase which oxidises prostaglandin F(2alpha) directly to E(2), thus producing a compound with more potent renal actions. The possible implications of this enzyme for kidney homeostasis are discussed.
High hopes and high honours for cancer immunotherapy (2019)

This issue of the Biomedical Journal honours the laureates of the 2018 Nobel Prize in Physiology and Medicine for their ground-breaking contributions to cancer immunotherapy and unveils the identification of essential intermediates between microtubule-targeting agents and apoptosis. Subsequently, we learn about the hypoglycemic properties of natural phenolic acids, how cone-beam computed tomography assists dental implant surgery and which factors should be taken into account for salvage liver transplantation after recurrent hepatocellular carcinoma. Further readings discuss the negative impact of bismuth shields on computed tomography image quality, the predictive value of warning headaches for aneurysmal subarachnoid haemorrhage and the great long-term performance of zirconia implant abutments.
Novel Molecular Markers for Late Phases of the Growth Cycle of Arabidopsis thaliana Cell-Suspension Cultures Are Expressed during Organ Senescence (1996)

In an Arabidopsis thaliana T87-C3 cell-suspension culture, entry into the growth-arrest phase is rapidly followed by a loss of cell viability. Three cDNA clones, SRG1, SRG2, and SRG3, corresponding to genes with transcripts that accumulate during these late phases, were isolated by the mRNA differential display method. Amino acid sequence analysis shows that the putative SRG1 protein is a new member of the Fe(II)/ascorbate oxidase superfamily, and that SRG2 codes for a protein with significant homology to beta-glucosidases. Significantly, all three SRG genes are expressed in senescing organs of Arbidopsis plants. Two previously characterized genes, SAG2 and SAG4, induced during natural senescence in Arabidopsis, were also found to be expressed in cell-suspension cultures and have expression kinetics similar to those observed for the SRG1 gene. Taken together these finding suggest that certain molecular events are common to both plant senescence and growth arrest in arabidopsis cell suspensions. Both internucleosomal cleavage of nDNA and an apparent compaction of chromatin, two characteristic features of programmed cell death in animal cells, have been observed in Arabidopsis cell cultures at a stage corresponding to loss of cell viability.
Consumer Bankruptcy Reform: Debtors' Prison without Bars or "Just Desserts" For Deadbeats? (2006)

This article provides an overview of current bankruptcy law and filing trends in the United States. It then provides an overview of the major changes to consumer bankruptcy and further analyzes several of the more controversial areas of the new law, placing them in historical context and exploring the possible ramifications of these dramatically sweeping changes. Such changes are illustrated by the journey of hypothetical debtors, Ura and Ima Broke, through the new bankruptcy maze. This illustration shows the complexity and inconsistency of the amended Bankruptcy Code. Examining the reform from the vantage point of hypothetical debtors shows how the reform can be viewed from two very different perspectives: as a return to debtors' prisons and early bankruptcy laws that treated debtors as "offenders" or as just desserts for deadbeat debtors.
On the optimal nesting order for computing <i>N</i> -relational joins (1984)

Using the nested loops method, this paper addresses the problem of minimizing the number of page fetches necessary to evaluate a given query to a relational database. We first propose a data structure whereby the number of page fetches required for query evaluation is substantially reduced and then derive a formula for the expected number of page fetches. An optimal solution to our problem is the nesting order of relations in the evaluation program, which minimizes the number of page fetches. Since the minimization of the formula is NP-hard, as shown in the Appendix, we propose a heuristic algorithm which produces a good suboptimal solution in polynomial time. For the special case where the input query is a “tree query,” we present an efficient algorithm for finding an optimal nesting order.
Derivatives of 4,9-Dihydro-<i>s</i>-indaceno[1,2-<i>b</i>:5,6-<i>b</i>‘]dithiophene-4,9-dione:  Synthesis and Properties (2007)

A new family of organic semiconducting materials (1-4) integrating the structural components of thiophene and fluorene into a single molecular entity was synthesized and characterized. Optical and electrochemical properties of these previously unknown 4,9-dihydro-s-indaceno[1,2-b:5,6-b']dithiophene-4,9-dione derivatives were studied in detail. These materials possess unique optical properties with the longest wavelength absorption maxima around 500-800 nm, which gradually reached a saturation limit with the total number of thiophene units approaching eight. They also display dramatic change in the redox properties with increasing conjugation chain lengths. A thin film of oligomer 3 prepared by a solution-casting method showed a well-ordered solid-state structure according to X-ray diffraction analysis.
Clinical and Muscle Imaging Findings in 14 Mainland Chinese Patients with Oculopharyngodistal Myopathy (2015)

Oculopharyngodistal myopathy (OPDM) is an extremely rare, adult-onset hereditary muscular disease characterized by progressive external ocular, pharyngeal, and distal muscle weakness and myopathological rimmed vacuole changes. The causative gene is currently unknown; therefore, diagnosis of OPDM is based on clinical and histopathological features and genetic exclusion of similar conditions. Moreover, variable manifestations of this disorder are reported in terms of muscle involvement and severity. We present the clinical profile and magnetic resonance imaging (MRI) changes of lower limb muscles in 14 mainland Chinese patients with OPDM, emphasizing the role of muscle MRI in disease identification and differential diagnosis. The patients came from 10 unrelated families and presented with progressive external ocular, laryngopharyngeal, facial, distal limb muscle weakness that had been present since early adulthood. Serum creatine kinase was mildly to moderately elevated. Electromyography revealed myogenic changes with inconsistent myotonic discharge. The respiratory function test revealed subclinical respiratory muscle involvement. Myopathological findings showed rimmed vacuoles with varying degrees of muscular dystrophic changes. All known genes responsible for distal and myofibrillar myopathies, vacuolar myopathies, and muscular dystrophies were excluded by PCR or targeted next-generation sequencing. Muscle MRI revealed that the distal lower legs had more severe fatty replacement than the thigh muscles. Serious involvement of the soleus and long head of the biceps femoris was observed in all patients, whereas the popliteus, gracilis and short head of biceps femoris were almost completely spared, even in advanced stages. Not only does our study widen the spectrum of OPDM in China, but it also demonstrates that OPDM has a specific pattern of muscle involvement that may provide valuable information for its differential diagnosis and show further evidence supporting the conclusion that OPDM is a unique disease phenotype.
Exact solution for the kinetics of the image reversal process (1986)

The model equations describing the image reversal process with positive photoresists have been solved by extending the recently derived analytical solution of Dill's equations for the exposure bleaching of positive photoresists. The solution is presented in a closed form that requires only simple numerical integrations to determine the time-dependent two-dimensional concentration profiles of the photoactive compound (PAC).
Converging Evidence in Support of the Serotonin Hypothesis of Dexfenfluramine-Induced Pulmonary Hypertension With Novel Transgenic Mice (2008)

The results suggest that peripheral serotonin is critical for the development of dexfenfluramine-induced pulmonary arterial hypertension and that dexfenfluramine and SERT overexpression have additive effects on pulmonary vascular remodeling. We propose that dexfenfluramine can also inhibit hypoxia-induced pulmonary vascular remodeling via SERT activity and inhibition of hypoxia-induced p38 mitogen-activated protein kinase.
A mobility model for pedestrian content distribution (2009)

Mobile communication devices may be used for spreading multimedia data without support of an infrastructure. Such a scheme, where the data is carried by people walking around and relayed from device to device by means of short range radio, could potentially form a public content distribution system
[Primary structure of class II human histocompatibility antigens. 1st communication. Amino acid sequence of the N-terminal 198 residues of the beta chain of a HLA-Dw2,2;DR2,2-alloantigen (author's transl)]. (1981)

From a lymphoblastoid homozygous cell-line (HLA-A3,3; B7,7; Dw2,2; DR2,2) the alpha-chain of the HLA-Dw2/DR2 antigen was isolated by an exclusively chemical procedure. The alpha- was separated from the beta-chain by chromatography with hydroxylapatite in Na-dodecyl sulfate. Here we describe the amino acid sequence of the alpha-chain up to Position 179. The molecule is divided into two domains which do not appear homologous to each other but show a significant homology to the beta-chain (21.2%). The similarity is larger in the second (27%) than in the first (15.5%) domain, indicating a different evolutionary relationship for both parts. In contrast to the beta-chain both domains contain an N-glycosidically linked carbohydrate. The methionines are positioned only in the N-terminal, the cysteines exclusively in the C-terminal domain. Only the latter can therefore be stabilized by a disulfide bridge. As with the beta-chain the regions around the cysteines show a remarkable similarity with the constant C-terminal domains of k-, lambda-, alpha-, gamma-, sigma-, epsilon- and mu-chains of immunoglobulins. Although to a considerably lesser extent, the alpha-chain preparation also shows a heterogeneity at the protein level. Since the employed cell-line is homozygous with regard to HLA-D/DR, our results indicate that at least two alpha-chain genes exist in the HLA-D/DR-region. Together with the already published sequence of the beta-chain, the extracellular part of an histocompatibility antigen of the HLA-D type is now known.
Techniques for Improving Engineering Productivity of VLSI Designs (1981)

The ability of the semiconductor industry to produce chips with higher and higher circuit densities has created a challenge for the product designer: to utilize this capacity and still develop chips rapidly at reasonable cost. A multi-faceted approach to VLSI design is described that significantly reduces product development time and resource from those required with existing methods. This approach is based on the use of PLA structures or macros. It consists of a hardware/software modeling technique, use of laser-personalizable PLAs for rapid modeling of PLA macros, and a method for repairing design errors (that may hide other errors) on the actual VLSI wafers with a laser tool. A two-pass VLSI design is therefore highly probable.
Entropy-constrained polar quantization and its application to audio coding (2005)

In this work, we present a new method for quantization of sinusoidal amplitudes and phases, and apply the method to sinusoidal coding of speech and audio signals. The method is based on unrestricted polar quantization, where phase quantization accuracy depends on amplitude. Amplitude and phase quantizers are derived under an entropy (average rate) constraint using high-rate assumptions. First, we derive optimal quantizers for one sinusoid and a mean-squared error distortion measure. We provide a detailed analysis of entropy-constrained unrestricted polar quantization, showing its high performance and practicality even at low rates. Second, we find optimal quantizers for a set of sinusoids that model a short segment of an audio signal. The optimization is performed using a weighted error measure that can account for the masking effect in the human auditory system. We find the optimal rate distribution between sinusoids, as well as the corresponding optimal amplitude and phase quantizers, based on the perceptual importance of sinusoids defined by masking. The new method is used in an audio-coding application and is shown to significantly outperform a conventional sinusoidal quantization method where phase quantization accuracy is identical for all sinusoids.
Regulation of messenger ribonucleic acid for corticotropin releasing hormone receptor in the pituitary during stress (1996)

The mechanism regulating pituitary CRH receptors during stress was studied by analysis of the changes in CRH receptor messenger RNA (mRNA) and CRH binding after acute and repeated stress and CRH and vasopressin (VP) administration in intact and adrenalectomized rats. Acute stress caused time- and stress type-dependent changes in pituitary CRH receptor expression. In situ hybridization studies showed biphasic changes in CRH receptor mRNA after immobilization stress for 1 h and decreases by 2 h (P < 0.01). Increases (P < 0.01) were seen 4 and 8 h after the initiation of the stress, and a return to near basal levels by 12 and 18 h. A different pattern, with a decrease by 4 h (P < 0.01) and levels similar to controls after 12 and 18 h, was observed after a single ip injection of hypertonic saline (1.5 M NaCl). Binding autoradiography showed significant increases in pituitary CRH binding 4, 10, and 12 h after immobilization stress, but significant decreases 4, 12, and 18 h after ip hypertonic saline. In contrast, repeated immobilization or ip hypertonic saline for 8 or 14 days increased pituitary CRH receptor mRNA, and CRH binding was decreased. To determine the role of hypothalamic CRH and VP on these stress-induced changes, rats were injected for 14 days with CRH, VP, or their combination at doses mimicking stress levels in pituitary portal circulation (1 microgram/day sc). Repeated injection of CRH or VP increased CRH receptor mRNA and CRH binding (P < 0.05). CRH receptor mRNA levels further increased after combined administration of CRH and VP (P < 0.01), but CRH binding showed a tendency to decrease. The role of glucocorticoids on CRH receptor regulation was studied by analysis of the effects of stress on CRH receptor mRNA and CRH binding in adrenalectomized (ADX) rats with and without corticosterone replacement in the drinking water. Although in 6-day ADX rats pituitary CRH receptor mRNA levels were markedly reduced after acute immobilization, glucocorticoid replacement restored the stimulatory effect of stress to levels observed in intact rats. Similarly, a single sc injection of CRH (1 microgram) decreased CRH receptor mRNA in ADX rats but not in glucocorticoid-replaced ADX rats. CRH binding showed the expected decrease after ADX and was unchanged after stress or CRH injection. The increased pituitary CRH receptor mRNA after stress suggests that stress-induced CRH receptor down-regulation is due to increased receptor occupancy and internalization rather than to a decrease in receptor synthesis. The data suggest that increased hypothalamic secretion of CRH and VP mediates the delayed up-regulatory effect of stress on CRH receptor mRNA, and that resting levels of glucocorticoids are required for this effect. In addition, increased VP levels are permissive for the down-regulation of CRH binding induced by chronic pituitary exposure to stress levels of CRH.
On Macroblock Partition for Motion Compensation (2006)

In the H.264/AVC video coding standard, motion compensation can be performed by partitioning macroblocks into square or rectangular sub-macroblocks in a quadtree decomposition. This paper studies a motion compensation method using wedges, i.e. partitioning macroblocks or sub-macroblocks into two regions by an arbitrary line segment. This technique allows the shapes of the divided regions to better match the boundaries between moving objects. However, there are a large number of ways to slice a block and searching exhaustively over all of them would be an extremely computer-intensive task. Thus, we propose a fast algorithm which detects the predominant edge orientations within a block in order to pre-select candidate wedge lines. Finally a comparison among macroblock partition methods is performed, which points to the higher performance of the wedge partition method.
Strength and durability of concretes containing 50% Portland cement replacement by fly ash and other materials (1990)

Results are presented from an investigation on the compressive strength and durability of concretes containing substitute materials at a 50% replacement level (by mass) of Portland cement. Seven fly ashes (sub-bituminous, bituminous, and lignitic), together with limestone and an inert material (silica flour), were used as replacement materials. Durability studies included freeze–thaw testing (ASTM C666A), scaling resistance (ASTM C672), and abrasion resistance (ASTM C944). The air void system was assessed using the modified point count method of ASTM C457. The results indicate that although concretes with a 50% replacement level of cementitious material did not perform as well as the control concretes with no replacement, such concretes were able to meet minimum durability requirements. As anticipated, air-entrainment is the overriding factor that allows concrete to meet freeze–thaw durability requirements. In the context of this study, compressive strength does not appear to be a significant factor in freeze–thaw durability. Results indicated that concretes with compressive strengths of less than 10 MPa will still pass the freeze–thaw test, provided an adequate air void system is in place. Abrasion resistance tends to increase with compressive strength but not in all the cases. Key words: concrete, fly ash, compressive strength, durability, mineral admixtures.
Updating Your Phone (2011)

Windows Phone 7 is a full operating system, with a team of designers and programmers constantly working on new features, fixing bugs, and refining the software so that you get the best experience. However, these new features and fixes would mean nothing if there wasn't a way for you to update your phone to get the best possible experience. This chapter covers the Windows Phone 7 update feature, including how to check for an update and install it if one is available for your phone.
Time-scale modification of speech based on a nonlinear oscillator model (2002)

Introduces a new signal model for speech: a nonlinear oscillator with a slowly time-varying state-space representation produces the full speech waveform at its output. Short-time stationary intervals of the waveform are interpreted as (transient) attractors of the underlying dynamical system. The model is adapted by building a 'state-transition codebook' (a table of all possible state transitions) for each speech frame. As a first test for the model the authors have developed a novel time-scale modification method for speech. This method produces high quality output at moderate computational cost.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Liposome-encapsulated aminoglycosides in pre-clinical and clinical studies (2001)

Liposome-encapsulated amikacin has recently entered clinical trials. The rationale for liposome encapsulation of aminoglycosides is the possibility to increase the therapeutic index of this class of antibiotics by increasing aminoglycoside concentrations at the site of infection and/or by reducing the toxicity of these drugs. Three approaches can be distinguished: the use of liposomes as a depot formulation for local drug administration; targeting of (relatively) short circulating conventional liposomes to the cells of the mononuclear phagocyte system (MPS) for treating intracellular bacterial infections; and targeting of long-circulating liposomes to infectious foci localized outside the MPS. This review discusses the pre-clinical and clinical data in connection with recent developments in liposome technology.
Metadata for efficient, secure and extensible access to data in a medical grid (2004)

We present the metadata usage in a medical imaging project grid. Metadata represent data about the data: In our case, the data are medical images and the metadata store relative information on the patient and hospital records, or even data about the image algorithms used in our application platform. Metadata are either static or dynamically constructed after computations on data. We show how the metadata is used, produced and stored to provide a secure and efficient access to medical data (and metadata) through a dedicated architecture. Experiments include times to access data and to secure the transactions.
The effect of DAD timeout period on address autoconfiguration in wireless ad-hoc networks (2011)

The position of any event in time could be in the present, past, or future. This temporal discrimination is vitally important in our daily conversations, but it remains elusive how the human brain distinguishes among the past, present, and future. To address this issue, we searched for neural correlates of presentness, pastness, and futurity, each of which is automatically evoked when we hear sentences such as "it is raining now," "it rained yesterday," or "it will rain tomorrow." Here, we show that sentences that evoked "presentness" activated the bilateral precuneus more strongly than those that evoked "pastness" or "futurity." Interestingly, this contrast was shared across native speakers of Japanese, English, and Chinese languages, which vary considerably in their verb tense systems. The results suggest that the precuneus serves as a key region that provides the origin (that is, the Now) of our time perception irrespective of differences in tense systems across languages.