gebhart/patrepeval huggingface dataset:
Mechanism-Based Inactivation of the Human Prolyl-4-hydroxylase by 5-Oxaproline-Containing Peptides:  Evidence for a Prolyl Radical Intermediate (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTMechanism-Based Inactivation of the Human Prolyl-4-hydroxylase by 5-Oxaproline-Containing Peptides: Evidence for a Prolyl Radical IntermediateMin Wu, Hong-Sik Moon, Tadhg P. Begley, Johanna Myllyharju, and Kari I. KivirikkoView Author Information Department of Chemistry and Chemical Biology Cornell University, Ithaca, New York 14853 Collagen Research Unit Biocenter and Department of Medical Biochemistry University of Oulu, Kajaanintie 52A FIN-90220, Oulu, Finland Cite this: J. Am. Chem. Soc. 1999, 121, 3, 587–588Publication Date (Web):January 6, 1999Publication History Received9 April 1998Published online6 January 1999Published inissue 1 January 1999https://pubs.acs.org/doi/10.1021/ja981193hhttps://doi.org/10.1021/ja981193hrapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views359Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical reactions,Genetics,Oxidation,Peptides and proteins,Reaction products Get e-Alerts
Fuzzy Control of Electrohydraulic Above-Knee Prostheses (1995)

A fuzzy controller is employed to control an electrohydraulic four-bar above-knee prosthesis for the swing phase in level walking. A two-dimensional (sagittal plane)mechanical model of the above-knee amputee is developed and the amputee prosthesis system is simulated for the swing phase. The man-machine system has two fuzzy controllers : a knee fuzzy controller which adjusts the knee damping moment so the prosthetic knee angle trajectory will track that of the patient's sound knee in the previous swing and a hip fuzzy controller utilized to model the way that an amputee will manipulate the prosthesis. From an optimal design procedure, a set of fuzzy controllers is found and an optimal relationship between variations of initial stump velocity and initial artificial shank velocity for the amputee is found. The results showed that the amputee swing gait can be controlled to a near normal one and walking with varied speed is possible.
Neutron angular distributions from fast-neutron-induced fission of<sup>232</sup>Th and<sup>238</sup>U (1977)

The angular distributions of prompt fission neutrons have been measured relative to the incident beam in the reactions 232Th(n,f) and 238U(n,f) using the Harwell 45 MeV electron linac to provide the fast-neutron source. The measurements employed conventional time-of-flight techniques to determine incident neutron energies and prompt neutrons were detected in NE213 organic scintillator counters equipped with pulse-shape discrimination to reject gamma ray events. The results of the measurements were consistent with prompt-neutron emission predominantly from fully accelerated fission fragments, the assumption being made that the neutrons were emitted isotropically in the fragment rest frame.
Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial (2012)

NCT00490802.
Stigmasterol hemihydrate (2002)

The title compound, stigmasta-5,22-dien-3beta-ol hemihydrate, C(29)H(48)O x 0.5H(2)O, previously thought to be the monohydrate, has two sterol molecules and one water molecule in the asymmetric unit. In both sterol molecules, the methyl group of the ethyl substituent at the end of the hydrocarbon chain is disordered over two sites. The OH group of molecule A donates a hydrogen bond to a water molecule and accepts a hydrogen bond from the OH group of molecule B. The OH group of molecule B accepts two hydrogen bonds from water molecules.
An improved embryo-rescue protocol for hybrid progeny from seedless Vitis vinifera grapes × wild Chinese Vitis species (2013)

A highly efficient technique of embryo rescue is critical when using stenospermocarpic <i>Vitis vinifera</i> cultivars (female parents) to breed novel, disease-resistant, seedless grape cultivars by hybridizing with wild Chinese <i>Vitis</i> species (male parents) having many disease-resistance alleles. The effects of various factors on the improvement of embryo formation, germination, and plantlet development for seven hybrid combinations were studied. The results indicated that Beichun and Shuangyou were the best male parents. The best sampling time for ovule inoculation differed among the female parents. When hybrid ovules were cultured on a double-phase medium with five different solid medium types, percent embryo formation was highest (11.3-28.3%) on a modified MM3 medium. Percentages of embryo germination (15.4-55.4%) and plantlet development (11.15-44.6%) were all highest when embryos were cultured on Woody Plant Medium + 5.7 μM indole-3-acetic acid + 4.4 μM 6-benzylaminopurine + 1.4 μM gibberellic acid + 2% sucrose + 0.05% casein hydrolysate + 0.3% activated charcoal + 0.7% agar. In the absence of other amino acids, the addition of proline significantly increased embryo formation (36.1%), embryo germination (64.6%), and plantlet development (90.5%). A highly efficient protocol has been developed for hybrid embryo rescue from seedless <i>V. vinifera</i> grapes × wild Chinese <i>Vitis</i> species that results in a significant improvement in breeding efficiency for new disease-resistant seedless grapes.
COMPARISON OF LIFESTYLE AND STRUCTURED EXERCISE APPROACHES IN GAUGING EXERCISE INTENSITY 827 (1996)

Project Active is a randomized clinical trial (N=237) comparing a 2-yr lifestyle (L) physical activity program with a structured (S) exercise program in sedentary but healthy adults aged 35-60 years. L uses the CDC/ACSM recommendation of accumulating 30 minutes of moderate intensity activity most days of the week and S uses the 1990 Exercise Prescription Guidelines as the basis for increasing physical activity and fitness in their respective groups. S is taught to use the ratings of perceived exertion (RPE) scale and heart rate (HR) to monitor exercise intensity while L is taught that moderate intensity activities are equivalent to brisk walking. Of interest is whether participants in L can adequately gauge exercise intensity by using RPE and whether there is a difference between S and L. Both groups were tested at baseline and at 6 months using the Bruce protocol and assessed on RPE at the end of each stage. Two multiple regression analyses were used to predict HR from RPE adjusted for age, gender, and% body fat in order to compare baseline to 6 months and to compare L to S at 6 months. At baseline and following 6 months intervention, S and L could equally gauge HR from RPE at stages 1, 2, and 3. In both S and L after 6 months of intervention, there was a significant association between HR and RPE at stage 2 (p ≤.05). Further analyses indicate that after 6 months of intervention, both groups tended to improve in ability to gauge HR from RPE. These results suggest that both S and L groups are comparable in their ability to gauge exercise intensity. Furthermore, the HR-RPE association may improve after 6 months of intervention.
Adenosine triphosphate–induced oxygen radical production and CD11b up-regulation: Ca++ mobilization and actin reorganization in human eosinophils (2000)

Eosinophils are major effector cells in cellular inflammatory conditions such as parasitic infections, atopic diseases, bullous dermatoses, and vasculitis. Biological activities of adenosine triphosphate (ATP) were characterized in human eosinophils and compared with those of other eosinophil activators such as complement fragment product C5a, platelet-activating factor (PAF), and eotaxin. ATP initiated production of reactive oxygen metabolites, as demonstrated by lucigenin-dependent chemiluminescence. Furthermore, ATP caused up-regulation of the integrin CD11b. In addition, fluorescence microscope measurements labeled with fura-2 (1-[2-(5-carboxy-oxazol-2-yl)-6-aminobenzofuran-5-oxy]-2-(2' -amino-5' -methyl-phenoxy)-ethane-N, N, N, N'-tetraacetic acid, pentaacetoxymethyl ester) eosinophils in the presence or absence of ethyleneglycotetraacetic acid (EGTA) indicated that there was Ca(++) mobilization from intracellular stores by ATP. Flow cytometric studies showed transient actin polymerization upon stimulation with ATP and its stable analogues adenosine 5'-0-(3-thiotriphosphate) and 2-methylthioadenosine triphosphate tetrasodium (met-ATP). The reactions induced by ATP were comparable to those obtained by C5a, PAF, and eotaxin. Production of reactive oxygen metabolites and actin polymerization after stimulation with ATP was inhibited by pertussis toxin, which indicated involvement of receptor-coupled guanine nucleotide-binding proteins (G(i) proteins). In addition, experiments with oxidized ATP also suggest involvement of P2X receptors in this activation process. The results show that ATP is a strong activator of eosinophils and has biological activity comparable to those of the eosinophil chemotaxins C5a, PAF, and eotaxin. The findings strongly suggest a role of ATP in the pathogenesis of eosinophilic inflammation as an activator of proinflammatory effector functions.
New agents for the selective reduction of the carbon-carbon double bond of .alpha.,.beta.-unsaturated carbonyl compounds (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew agents for the selective reduction of the carbon-carbon double bond of .alpha.,.beta.-unsaturated carbonyl compoundsYutaka Nishiyama, Masanori Yoshida, Shigeo Ohkawa, and Sawako HamanakaCite this: J. Org. Chem. 1991, 56, 23, 6720–6722Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/jo00023a047https://doi.org/10.1021/jo00023a047research-articleACS PublicationsRequest reuse permissionsArticle Views609Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Invited Article Experimental techniques for the investigation of ferroelectric liquid crystals (1987)

Abstract A review is given of several experimental methods for the measurement of the performance parameters of ferroelectric liquid crystals. We discuss (a) the technique for measuring the spontaneous polarization, the elastic modulus and dielectric susceptibility for the tilt of the director (the pyro-electric method), (b) the measurement of the tilt angle and the optical anisotropy (the electro-optical method) and (c) the determination of the non-linear susceptibility of the chiral smectic C∗ phase (the optical second harmonic generation technique).
[The European Union and the migrations of populations. Government logic and human rights]. (1996)

"The first part of this article consists of a summary of the major [immigration] reforms undertaken by the EU [European Union] states over the past decade. The second chapter discusses the ways in which these reforms were drafted, and, in particular, the influence of intergovernmental negotiations on national policy. The third part, relative to the regulation of job markets, underscores the contrast between the tough restrictions on permanent employment of foreigners and flexibility...for administering seasonal immigration or entry visas granted within the context of temporary work contracts. The fourth part, which analyzes the impact of these legislative changes on individual rights, logically leads to a discussion of the foundation of the procedure followed by the wealthy countries, and points out the shortcoming of a strictly punitive or even military solution to what is chiefly a problem of development and democracy." (SUMMARY IN ENG AND SPA)
Automatic Extraction of Publication Time from News Search Results (2006)

The publication time of a page can have a big impact on its relevance to a query, especially for time-sensitive pages such as news items. For news search engines, the publication time of news items can usually be found in the returned search result records. In this paper, we introduce a method that can automatically extract the publication time for each news story returned from news search engines based on several important observations we made. We also introduce a wrapper implementation for the extraction method. The experimental results using data collected from 50 news search engine show that our method is effective and the wrapper implementation can not only improve the extraction accuracy but also the extraction efficiency.
Water-based synthesis of zeolitic imidazolate framework-8 with high morphology level at room temperature (2015)

Additive-free synthesis of ZIF-8 with perfect morphology in water at room temperature involves 3 key reactions and 5 evolutional steps.
Kinetic Monte Carlo study of accelerated optimization problem search using Bose-Einstein condensates (2011)

In a previous work [ArXiv:0909.2530] we proposed a method for accelerating optimization problem search using Bose-Einstein condensation (BEC). The system encodes an optimization problem into an Ising model and cools it down by the process of BEC to find its ground state spin configuration which corresponds to the solution of the problem. The system uses the final state stimulation (FSS) property of bosonic particles, an effect originating from the quantum indistinguishability of bosons, to provide speedups over the classical case. The speedup is typically N, where N is the number of bosons in the system per site. In this article we firstly review the proposed system, and give a more detailed numerical study of the equilibration time with the boson number and the number of sites M in the Ising model. We find that the equilibration time scales as exp(M)/N in agreement with previous arguments based on simulated annealing. A detailed description of the kinetic Monte Carlo method used for the study of the proposed system is also discussed.
Overview of Phase-Change Materials Based Photonic Devices (2020)

Non-volatile storage memory is widely considered to be one of the most promising candidates to replace dynamic random access memory and even static random access memory. It has recently received particular attention because of its great potential for brain-like neuromorphic applications. Phase-change materials, also known as Chalcogenide alloys, exhibit several especially advantageous traits for non-volatile applications. These include scalability, fast switching speeds, low switching energy and outstanding thermal stability. As a result, most research to date has sought to identify electrical applications for phase-change materials in relation to phase-change random access memory, phase-change memristors and phase-change neuro networks, while overlooking their potential for non-volatile photonic applications. To address this issue, we provide a comprehensive review that examines the remarkable physical properties of phase-change materials for photonic applications, together with emerging phase-change photonic devices. The review begins by presenting the atomic structure and physical properties of phase-change materials, followed by an elaboration of the issues that phase-change materials are currently facing and the strategies being developed to overcome them. The current state-of-the-art and technical challenges confronting phase-change materials in relation to non-volatile photonic applications, such as phase-change photonic memory, phase-change photonic neuro-networks, phase-change metasurfaces and phase-change color displays are then considered. The review concludes by discussing the outlook for successfully implementing phase-change materials in emerging photonic domains.
Installation of a hydraulic kiln drive to eliminate a resonant vibration problem (2002)

Large dual electromechanical drive systems have been shown to often experience vibration problems due to both the high inertia of the components of these systems, and the large number of resonant frequencies experienced by these drives. Hydraulic drives, by comparison, are extremely low inertia drives, that have fewer resonant frequencies and benefit from the damping characteristic of the hydraulic oil used to transmit power. Additional benefits include the ability to isolate components while operating the drive and smooth speed control starting at extremely low speeds and full rated torque. This paper outlines the vibration problems that were experienced in a dual drive of a 655' long with 22' and 19' diameter section rotary cement kiln between 1979 and 1993. A number of analytical and empirical studies were performed and various modifications were made or considered to reduce the vibration in the drive train. Finally, in 1994 when the existing drive reached the end of its life, it was replaced with a hydraulic system. The methods both used and considered to reduce the vibration are discussed, as well as the critical elements in deciding on a hydraulic drive and the design issues encountered including questions of drive efficiency, reliability, maintenance and control. Results to date of the hydraulic drive are discussed, including the elimination of the vibration problem and added flexibility in speed control.
Water and Energy Consumption in Domestic Laundering Worldwide – A Review (2016)

Abstract A literature review was executed to collect data on the resource consumption connected to domestic laundering processes. Data from literature on water and energy consumption were collected. The study focussed on Europe, as for Europe enough date could be collected for a thorough analysis. However, the limited data available for Japan and the USA were also included and discussed.
Experiences in implementing an experimental wide-area GMPLS network (2007)

In this article, we describe our experiences in implementing an experimental wide-area GMPLS network called CHEETAH (circuit-switched end-to-end transport architecture). The key concept is to add a complementary end-to-end circuit based service with dynamic call-by-call bandwidth sharing to the connectionless service already available to end hosts via the Internet. The current CHEETAH experimental network consists of off-the-shelf GMPLS-capable SONET switches (with Ethernet interfaces) deployed at three locations, Research Triangle Park, North Carolina, Atlanta, Georgia, and Oak Ridge, Tennessee. We describe our solutions to various problems relating to control-plane design, IP addressing and control-plane security. We designed and implemented a CHEETAH software package to run on Linux end hosts connected to the CHEETAH network. Among other functions, this software package includes an RSVP-TE module to enable end users and applications to dynamically initiate requests for dedicated end-to-end circuits and receive/respond to requests for circuits. We present measurements for typical end-to-end circuit setup delays across this network. For example, end-to-end circuit setup delay from a Linux end host in NC to a host in Atlanta is 166 ms
Design parameters estimations for bubble column reactors (1982)

Abstract Gas‐liquid as well as gas‐liquid‐solid bubble column reactors are extensively used in the chemical industry. This review evaluates the present state of the art for the estimation of “nonadjustable” parameters in bubble column reactors. All the pertinent literature concerning these parameters is discussed and the discussion is followed by relevant recommendations for their predictions. Literature on the modified bubble columns has been incorporated. Finally, the inadeqacies of the data in some areas of practical importance have been pointed out and the recommendations for future work are outlined.
Therapeutic targeting of CD70 and CD27 (2016)

Therapeutic strategies have been developed that either aim to trigger or inhibit CD27 activity or solely use CD70 as a tumor marker. Some of these strategies are currently under consideration in clinical trials and have shown a good safety profile. The identification of biomarkers and stratification concepts is now important to ensure that a chosen CD70/CD27 targeting strategy fits optimally to the dominant function(s) of CD70 and CD27 in the corresponding individual case.
Chloramphenicol Acetyltransferase: Enzymology and Molecular Biology (1983)

Naturally occurring chloramphenicol resistance in bacteria is normally due to the presence of the antibiotic inactivating enzyme chloramphenicol acetyltransferase (CAT) which catalyzes the acetyl-S-CoA-dependent acetylation of chloramphenicol at the 3-hydroxyl group. The product 3-acetoxy chloramphenicol does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase. The synthesis of CAT is constitutive in E. coli and other Gram-negative bacteria which harbor plasmids bearing the structural gene for the enzyme, whereas Gram-positive bacteria such as staphylococci and streptococci synthesize CAT only in the presence of chloramphenicol and related compounds, especially those with the same stereochemistry of the parent compound and which lack antibiotic activity and a site of acetylation (3-deoxychloramphenicol). Studies of the primary structures of CAT variants suggest a marked degree of heterogeneity but conservation of amino acid sequence at and near the putative active site. All CAT variants are tetramers composed in each case of identical polypeptide subunits consisting of approximately 220 amino acids. The catalytic mechanism does not appear to involve an acyl-enzyme intermediate although one or more cysteine residues are protected from thiol reeagents by substrates. A highly reactive histidine residue has been implicated in the catalytic mechanism.
Inhaled corticosteroids in the treatment of respiratory allergy: safety vs. efficacy (2006)

ICS are the main anti-inflammatory agent used to treat persistent asthma. When administered in low doses, they seem to be safe and effective. Patient monitoring allows for early detection of possible side effects associated with ICS.