gebhart/patrepeval huggingface dataset:
In Vitro Anti-Human Immunodeficiency Virus Activities of <i>Z</i> - and <i>E</i> -Methylenecyclopropane Nucleoside Analogues and Their Phosphoro- <scp>l</scp> -Alaninate Diesters (1999)

Nucleoside analogues with a Z- or an E-methylenecyclopropane moiety were synthesized and examined for activity against human immunodeficiency virus type 1 (HIV-1) in vitro. The addition of a methyl phenyl phosphoro-L-alaninate moiety to modestly active analogues resulted in potentiation of their anti-HIV-1 activity. Two such compounds, designated QYL-685 (with 2,6-diaminopurine) and QYL-609 (with adenine), were most potent against HIV-1 in vitro, with 50% inhibitory concentrations of 0.034 and 0.0026 microM, respectively, in MT-2 cell-based assays. Both compounds were active against zidovudine-resistant, didanosine-resistant, and multi-dideoxynucleoside-resistant infectious clones in vitro. Further development of these analogues as potential therapies for HIV-1 infection is warranted.
A high fidelity ungrounded torque feedback device: The iTorqU 2.0 (2009)

This paper discusses the design and operation of the iTorqU 2.0, an ungrounded, handheld torque feedback device for haptic applications. Based upon the gyroscopic effect, the iTorqU 2.0 uses a metal flywheel inside of a two-axis actuated gimbal to create directional torques that are applied to the user's hand. The coupling of angular velocity and angular momentum creates a torque that is orthogonal to the two input angular velocities, giving the user the impression that their hand is being twisted in free air. Following a review of prior work in the field of ungrounded torque feedback devices, we first present our preliminary prototype, the iTorqU 1.0. Building on empirical observations and user feedback from a public demonstration, we revised and augmented this design to create the iTorqU 2.0. This paper covers the major mechanical, electrical, and controls design considerations that went into creating the iTorqU 2.0, along with an analysis of its torque output capabilities.
On-line tests of organic additives for the inhibition of the precipitation of silica from hypersaline geothermal brine II. Tests of nitrogen-containing compounds, silanes, and additional ethoxylated compounds (1979)

Several new classes of organic compounds have been screened as potential geothermal scale control agents by examining their effect on the precipitation of silica from Magmamax No. 1 brine. The substances were tested using the Lawrence Livermore Laboratory Brine Treatment Test System at the Niland, California, Test Site. Solutions of the test substances were injected into flowing brine at 210{sup 0}C, the brine was flashed to 125{sup 0}C, and then the kinetics of solids and silica precipitation from effluent brine held at 90{sup 0}C were measured. Three new types of compounds were shown to have activity as precipitation inhibitors: polyethylene imines, polyethyloxazalines, and quaternary ammonium compounds containing polyoxyethylene. Among the latter, Ethoquad 18/25, which is methyl-polyoxyethylene(15) octadecylammonium chloride, is the leading candidate antiscalant. It is a more powerful inhibitor of silica precipitation than the pure polyoxyethylene polymers, and it apparently has no high temperature solubility limitations. Measurements were made of the concentrations of monomeric silica and the effect of addition of inhibitor at various points in the Brine Treatment Test System. Five different silane compounds showed no activity toward silica.
Digestion of Peptides from Sardine Muscle That Inhibit Angiotensin I Converting Enzyme by Intestinal Enzymes of Pigs. (1992)

Three peptides (I:Leu-Lys-Leu, II:Val-Lys-Ala-Gly-Phe, and III: Lys-Val-Leu-Ala-Gly-Met) from a hydrolyzate of sardine muscle and that inhibited angiotensin I converting enzyme were digested with the intestinal fluid of pigs. The IC50 values of II and III were decreased to 56% and 66% of the original value, respectively, after digestion. Peptide I was not digested. Five peptide fragments were isolated from the peptide digests by high-pressure liquid chromatography. By the Edman procedure, peptide II digest was found to contain the fragments Val-Lys-Ala-Gly and Gly-Phe, and peptide III digest was found to contain the fragments Ala-Gly-Met, Lys-Val-Leu-Ala-Gly, and Lys-Val-Leu.
Zone-Refined Boron (1959)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation F. H. Horn; Zone‐Refined Boron. Journal of Applied Physics 1 October 1959; 30 (10): 1612–1613. https://doi.org/10.1063/1.1735011 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioJournal of Applied Physics Search Advanced Search |Citation Search
Control of rats and mice: Effectiveness requires continuous application of proven methods (1948)

The following article is a condensation of a portion of Circular 142 “Control of Rats and Mice” published by the California Agriculture Extension Service. The complete, illustrated circular may be obtained without cost from the local Farm Advisor or by addressing Publications Ofice, College of Agriculture, University of California, Berkeley 4, California.
Role of Krüppel-like factors in leukocyte development, function, and disease (2010)

The Krüppel-like transcription factor (KLF) family participates in diverse aspects of cellular growth, development, differentiation, and activation. Recently, several groups have identified new connections between the function of these factors and leukocyte responses in health and disease. Gene targeting of individual KLFs in mice has uncovered novel and unexpected physiologic roles among myeloid and lymphocyte cell lineage maturation, particularly in the bone marrow niche and blood. In addition, several KLF family members are downstream targets of stimuli and signaling pathways critical to T-cell trafficking, T regulatory cell differentiation or suppressor function, monocyte/macrophage activation or renewal, and B memory cell maturation or activation. Indeed, KLFs have been implicated in subtypes of leukemia, lymphoma, autoimmunity, and in acute and chronic inflammatory disease states, such as atherosclerosis, diabetes, and airway inflammation, raising the possibility that KLFs and their upstream signals are of therapeutic interest. This review focuses on the relevant literature of Krüppel-like factors in leukocyte biology and their implications in clinical settings.
Facile and Efficient Sulfenylation Method Using Quinone Mono-<i>O,S</i>-Acetals under Mild Conditions (2001)

A novel sulfenylation method induced by aromatization of quinone mono-O,S-acetals is described. These sulfenylation reagents readily react with silyl enolethers or electron rich aromatic compounds to give sulfenylation products under mild conditions. In particular, O,S-acetal 2j, which possesses a pentafluorophenylthio function, is the most effective reagent from the standpoint of the adaptability for various substrates.
Viscoelastic studies of extracellular matrix interactions in a model native collagen gel system (1994)

We describe an in vitro test of the hypothesis that viscoelastic properties of the collagen fiber network of skin are influenced by interactions between the macromolecular components in the extracellular matrix. Native type I collagen gels were investigated as a mechanical analog for connective tissue. A series of gels were formed under physiological conditions via fibril precipitation in the presence of selected matrix macromolecules, including dermatan sulfate (DS), hyaluronic acid (HA), dermatan sulfate proteoglycan (DSPG), fibronectin (FN) and elastin. Viscoelastic measurements and transmission electron microscopy were performed to explore the relationship between mechanical strength and fibril morphology. The results demonstrate that associative interactions of DSPG and HA with collagen fibrils, as well as variations in collagen fibril size distribution and the amount of elastin, can modify the viscoelastic behavior of the model collagen gels. Addition of DSPG, DS and HA increases both storage and loss moduli, G' and G"; morphological examination shows adhesive binding of these species to the collagen fibrils. At 37 degrees C, elastin increases G' by forming elastic coacervate particles. FN has no effect on the gel viscoelasticity. The observed effects are discussed in terms of current clinical observations on age-related changes in the mechanical properties of skin.
Antioxidant activity of tea extracts in lipids and correlation with polyphenol content (2006)

Abstract The present study examined the antioxidative activity of water and ethanol extracts of green and black tea leaves against the oxidation of heated sunflower oil and lard. Oxidation was conducted at 110 °C in the Rancimat test. Total polyphenols and catechin contents in tea extracts were measured. The research showed that the total polyphenol content in green and black tea leaves was 205.2 and 148.7 mg/g, respectively. In tea leaves extracts, it ranged between 245.9 mg/g and 837.7 mg/g and depended on the extraction solvent and the kind of tea used ( p <0.001). The highest polyphenol content was observed in samples extracted with 95% ethanol, lower contents were found with the use of water. Results showed that the highest antioxidant activity, measured as an induction period, with 1000 ppm green tea ethanol extract, was comparable to á‐tocopherol activity in sunflower oil. In lard, the longest induction period was measured with 500 and 1000 ppm of green tea ethanol extract. Other tea extract concentrations were significantly less active. Statistical analysis of the tea extract antioxidant activity in lipids in the Rancimat test showed an essential influence of the catechin contents. Further statistical analysis also showed an influence of (−)‐epicatechin gallate (ECG), (−)‐epicatechin (EC), and (+)‐catechin (C) contents in the tea extracts on the antioxidant activity in lipids. It was stated that the antioxidant activity was higher in tea extracts containing high levels of ECG, EC, and C.
Large-Scale 3D Printing: The Way Forward (2018)

Research on small-scale 3D printing has rapidly evolved, where numerous industrial products have been tested and successfully applied. Nonetheless, research on large-scale 3D printing, directed to large-scale applications such as construction and automotive manufacturing, yet demands a great a great deal of efforts. Large-scale 3D printing is considered an interdisciplinary topic and requires establishing a blended knowledge base from numerous research fields including structural engineering, materials science, mechatronics, software engineering, artificial intelligence and architectural engineering. This review article summarizes key topics of relevance to new research trends on large-scale 3D printing, particularly pertaining (1) technological solutions of additive construction (i.e. the 3D printers themselves), (2) materials science challenges, and (3) new design opportunities.
The Metabolism of Brain and Nerve (1934)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Evaluation of Data Storage Patterns in Microservices Archicture (2020)

A microservice is an architectural style that structures an application as group of loosely-coupled services that are independently deployable and centered around the business capabilities. Since microservices are a shift from the conventional monolithic application which normally uses a relational database backend, it becomes essential that attention be given to data storage structure for Microservices. In this research, we would examine five possible data storage patterns for microservices. The evaluation would include setting up prototypes and evaluating the performance of both RDBMS and document-store enabled data stores for microservice architecture. To carry out the evaluations, the five existing patterns for data persistence in microservice architecture were modeled: shared database, per-service pattern(3 variations) and the CQRS/EV pattern. Then a simplified hypothetical Electronic Medical Record(EMR) was designed and implemented using of the five existing patterns under consideration. The results of the evaluation in terms of performance and resource utilization are presented in this work.
Prostatic Ductal System in Rats: Regional Variation in Morphological and Functional Activities1 (1990)

The rat prostate is a complex ductal system with branches and subbranches extending from one end to another. Owing to the relative distance of various regions of the duct from the urethra, the entire length of the ductal system can be arbitrarily divided into three segments, i.e., the proximal, intermediate, and distal segments. The present study was carried out to assess the regional variation in cellular activities in this ductal system. Ventral prostates from adult Sprague-Dawley rats were dissected so that an individual ductal system was mechanically isolated and longitudinally sectioned to reveal various segments. Epithelial cells lining distal segments were tall-columnar type and were actively engaging in mitotic activity. Cells in intermediate segments were also tall-columnar type. However, they were mitotically quiescent, but able to produce secretory proteins. Evidence of programmed cell death was not observed in either of these two segments. Cells in proximal segments, on the other hand, were low-columnar or cuboidal in shape and were stained heavily for cathepsin D, a marker associated with late manifestation of cell death. Following castration in adult rats, there was a reversal in the site of programmed death in cells lining the ductal system. By Day 4 post-castration, distal segments contained many epithelial cells with intense cytoplasmic staining for cathepsin D while proximal segments showed a reduction in number of positively stained cells. By Day 7 post-castration, cells in proximal segments, though atrophied, were devoid of staining for cathepsin D.(ABSTRACT TRUNCATED AT 250 WORDS)
Grafting Poly(methyl methacrylate) onto Polyimide Nanofibers via “Click” Reaction (2009)

Surface modification of azide-decorated polyimide (PI) nanofibers with well-defined alkyne-terminated poly(methyl methacrylate) (PMMA) was accomplished via the combination of atom transfer radical polymerization (ATRP) and "click" chemistry. In this work, PI nanofibers were prepared via electrospun polyamic acid (PAA), followed by thermal imidization. Grafting of PMMA onto PI nanofibers was accomplished in three steps: (1) choloromethylation and azidization of PI nanofibers; (2) preparation of alkyne-terminated PMMA by ATRP of methyl methacrylate in toluene using propargyl 2-bromopropionate as initiator; (3) click coupling between the azidized PI nanofibers and the alkyne-terminated PMMA under the catalysis of Cu(I)Br/N,N,N',N''-pentamethyldiethylenetriamine (PMDETA). Gel permeation chromatography (GPC), (1)H NMR, and Fourier transform infrared (FT-IR) all confirmed the structure of alkyne-terminated poly(methyl methacrylate). The modified surface was characterized by X-ray photoelectron spectroscopy (XPS) after each modification stage. XPS and scanning electron microscope (SEM) were utilized to confirm PMMA-functionalized PI nanofibers, showing polymer coatings present on the surface of PI nanofibers. PI-g-PMMA nanofibers exhibited a more significant reinforcing effect compared to that with ungrafted PI nanofibers.
Atrial Natriuretic Peptide Suppresses the Transcription of Its Guanylyl Cyclase-linked Receptor (1995)

Atrial natriuretic peptide (ANP) treatment of rat aortic smooth muscle cells suppressed both 125I-ANP binding and ANP-dependent cGMP accumulation, suggesting reductions in the type C (NPR-C) and type A (NPR-A) natriuretic peptide receptor populations, respectively. NPR-A, but not NPR-C, mRNA levels were reduced in a dose-dependent fashion by ANP. The latter effect appeared to be due, at least in part, to suppression of NPR-A gene promoter activity. ANP effected a dose- and time-dependent reduction in a transiently transfected NPR-A luciferase reporter (-1575LUC). Analysis of 5' deletion mutants of the NPR-A promoter demonstrated that the ANP-dependent sequence lies between -1575 and -1290 relative to the transcription start site. Inhibition of the ANP promoter was also effected by brain natriuretic peptide, type C natriuretic peptide, and 8-bromo-cGMP, but not by the NPR-C-selective ligand cANF. In the case of 8-bromo-cGMP, the responsive element(s) was localized to the same 285-base pair region linked to the ANP effect above. These findings indicate that ANP autoregulates its own receptors in these cells and, at least in the case of NPR-A, it does so through suppression of receptor gene expression and receptor synthesis. This suppression may operate through a cGMP-dependent element located more than a kilobase upstream from the transcription start site.
The Interstitial Cells of Cajal and a Gastroenteric Pacemaker System (2002)

In spite of a claim by Kobayashi (1990) that they do not correspond to the cells originally depicted by CAJAL, a particular category of fibroblast-like cells have been identified in the gut by electron microscopy (Faussone-Pellegrini, 1977; Thuneberg, 1980) and by immunohistochemistry for Kit protein (Maeda et al., 1992) under the term of the "interstitial cells of Cajal (ICC)". Generating electrical slow waves, the ICC are intercalated between the intramural neurons and the effector smooth muscular cells, to form a gastroenteric pacemaker system. ICC at the level of the myenteric plexus (IC-MY) are multipolar cells forming a reticular network. The network of IC-MY which is believed to be the origin of electrical slow waves is morphologically independent from but associated with the myenteric plexus. On the other hand, intramuscular ICC (IC-IM) usually have spindle-shaped contours arranged in parallel with the bulk smooth muscle cells. Associated with nerve bundles and blood vessels, the IC-IM possess receptors for neurotransmitters and such circulating hormones as cholecystokinin, suggesting their roles in neuromuscular and hormone-muscular transmissions. In addition, gap junctions connect the IC-MY and IC-IM, thereby realizing the electrically synchronized integrity of ICC as a pacemaker system in the gut. The smooth muscle cells are also coupled with ICC via gap junctions, and the functional unit thus formed enables rhythmically synchronized contractions and relaxations. It has recently been found that a lack of Kit-expressing cells may induce hyper-contractility of the tunica muscularis in vitro, whereas a decrease in Kit expression within the muscle wall causes dysmotility-like symptoms in vivo. The pacemaker system in the gut thus seems to play a critical role in the maintenance of both moderate and normal motility of the digestive tract. A loss of Kit positive cells has been detected in several diseases with an impaired motor activity, including diabetic gastroenteropathy. Pathogenesis of these diseases is thought to be accounted for by impaired slow waves and neuromuscular transmissions; a pacemaker disorder may possibly induce a dysmotility-like symptom called 'gastroenteric arrhythmia'. A knowledge of the structure and function of the ICC and the pacemaker system provides a basis for clarifying the normal mechanism and the pathophysiology of motility in the digestive tract.
Intraductal Meibomian Gland Probing in the Management of Ocular Rosacea (2012)

Intraductal meibomian gland probing is a safe, effective technique to address the ocular surface disease, tearing, and discomfort associated with ocular rosacea, and this intervention results in a dramatic improvement in these symptoms. This study provides the first documentation of these findings and represents the first quantitative demonstration of the use of intraductal meibomian gland probing in the peer-reviewed literature.
An efficient estimation algorithm for the calibration of low-cost SS-OCT systems (2017)

In this paper, we present a real-time instantaneous phase estimation technique for the calibration of swept source optical coherence tomography (SS-OCT) systems. The proposed algorithm is able to accurately estimate both the amplitude and phase content of a swept source signal. The results are robust in the presence of substantial noise. Furthermore, the resulting phase profile is readily unwrapped, allowing for the generation of a k-linear sampling clock by means of a simple comparison step, which enables the SS-OCT system operator to determine the required number of points for accurate image reconstruction without the need for MZI path length modification. Our Simulations exhibit equivalent results with Hilbert transform based calibration techniques and low computational time rendering it suitable for real time applications.
Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli (2000)

CD163, also referred to as M130, a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage. In freshly isolated monocytes the CD14bright CD16+ monocyte subset revealed the highest expression of CD163 among all monocyte subsets. CD163 mRNA and protein expression is up-regulated during macrophage colony-stimulating factor (M-CSF)-dependent phagocytic differentiation of human blood monocytes. In contrast, monocytic cells treated with GM-CSF and interleukin-4 (IL-4) for dendritic differentiation down-regulate this antigen. CD163 expression is also suppressed by proinflammatory mediators like lipopolysaccharide (LPS), interferon-gamma (IFN-gamma), and tumor necrosis factor alpha, whereas IL-6 and the antiinflammatory cytokine interleukin-10 (IL-10) strongly up-regulate CD163 mRNA in monocytes and macrophages. The effects of the immunosuppressants dexamethasone, cyclosporin A (CA), and cortisol differ in their capacity to influence CD163 mRNA levels. Our results demonstrate that CD163 expression in monocytes/macrophages is regulated by proinflammatory and antiinflammatory mediators. This expression pattern implies a functional role of CD 163 in the antiinflammatory response of monocytes.
Proceedings of the fifth international workshop on Mobile cloud computing & services (2014)

We are pleased to welcome you to the fifth ACM Workshop on Mobile Cloud Computing and Services, co-located with ACM MobiSys 2014.

The workshop had an open call for papers; the TPC Co-chairs and TPC members also reached out to their colleagues for potential invited papers. In the end, all authors opted for the open call and all submissions underwent the standard peer review process by the TPC. We received nine submissions. The reviews were double-blind but we allowed the authors to disclose their identities if they so preferred. Each submission received at least four reviews in a single round; most submissions received five. This was followed by on-line and email discussion by the reviewers to reach a consensus. One of the submissions was co-authored by a TPC Co-chair and was therefore handled by the other Co-chair out of the band. The reviewers were instructed that the submission should not be accepted if it was borderline.

We ended up accepting six submissions with half of them being Vision papers. We are very pleased by the quality of the accepted papers. The papers cover a wide range of technological problems about using cloud for mobile services, from networking to novel applications in home automation. The workshop program also includes one keynote and three invited talks that feature speakers from academia, industry, and non-profit organization.