gebhart/patrepeval huggingface dataset:
Intramolecular Interactions between Nonbonded Chromophores. The Spectra of Some Phenylsilanes and Siloxanes (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular Interactions between Nonbonded Chromophores. The Spectra of Some Phenylsilanes and SiloxanesJohn F. Brown and Paul I. PrescottCite this: J. Am. Chem. Soc. 1964, 86, 7, 1402–1409Publication Date (Print):April 1, 1964Publication History Published online1 May 2002Published inissue 1 April 1964https://pubs.acs.org/doi/10.1021/ja01061a028https://doi.org/10.1021/ja01061a028research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pain Management: Expanding the Pharmacological Options (2008)

Foreword. 1 Introduction. 2 Conventional Pain Treatment. 3 Using Drugs Outside Their Licensed Indication. Part 1. 4 Topical Nitrates. 5 Topical Tricyclic Antidepressants. 6 Topical Opioids. 7 Topical Local Anesthetics. 8 Topical Glutamate Receptor Antagonists. 9 Topical, Oral, and Perineural-Adrenoreceptor Agonists. 10 Lamotrigine. 11 5HT3 Antagonists. 12 Cholecystokinin Antagonists. 13 Parenteral Anti-epileptics. 14 Intravenous Lidocaine. 15 L-Carnitine. 16 Other Pharmacological Options (Botulinum, Cimetidine, Glucosamine). Part 2. 17 Neuropathic Pain. 18 Complex Regional Pain Syndrome. 19 Joint Pain. 20 Fracture Pain. 21 Postoperative Pain. 22 Fibromyalgia. 23 Muscle Spasm and Pain. 24 Tendinopathies. 25 Low Back Pain. 26 Cancer Pain. Appendix: Suggested Doses and Modes of Administration of Novel Pharmacological Options. Index.
Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography (2004)

Matrix Gla protein (MGP) is an extracellular matrix protein with wide tissue distribution. It has been demonstrated that the expression of MGP is detected not only in the normal blood vessels but also calcified atherosclerotic plaques, and that MGP deficient mice develop extensive arterial calcification. MGP is thought to be a regulator of vascular calcification. A recent clinical study demonstrates the association between polymorphisms of the MGP gene and increased risk of myocardial infarction. However, there are no reports of the relationship between serum MGP levels and coronary artery calcification (CAC). We evaluated the severity of CAC using electron-beam computed tomography (EBCT), and measured serum MGP levels by enzyme-linked immunosorbent assay in 115 subjects with suspected coronary artery disease. CAC scores were correlated with traditional risk factors, such as age, gender, hyper-tension, diabetes, hyperlipidemia and smoking. The serum MGP levels were lower in patients with CAC than in those without CAC (p<0.001). As the severity of CAC increased, there was a significant decrease in serum MGP levels. Serum MGP levels (U/L) were 116.7 +/- 20.3, 104.9 +/- 19.2, 95.2 +/- 15.2 and 82.2 +/- 19.7, (medians 115.5, 105.0, 94.8, and 81.9) for the subjects with normal (CAC score=0), mild (CAC score=1 to 99), moderate (CAC score=100 to 400), and severe (CAC score >400) coronary calcification, respectively. We found that serum MGP levels are inversely correlated with the severity of CAC. These data suggest a possible role for MGP in the development of vascular calcification.
Seeing the Real World: Sharing Protected Data in Real Time (2012)

We describe a new capability for "owners" of protected data to quickly and securely share real time data among networked decision-support and real-time control devices with whom the "owners" of the data have explicitly decided to "share the data. The service is based upon implementation of a recent formal definition and mathematical result (James et al. 2009) derived from the decades-old Bell-LaPadula information security result (Bell and LaPadula, 1973). The service provides decision makers a means of securely and automatically sharing critical information across security barriers based upon declaration of sharing policies. The declaration and implementation of information sharing policies based upon a need-to-share has been shown to be compatible with information protection policies based upon a need-to-know. Indeed, the implementation of the need-to-share service is based upon extending the mathematical foundations of need-to-know information security systems (the Bell-LaPadula result of 1973).
Holin locus characterisation from lysogenic Xenorhabdus nematophila and its involvement in Escherichia coli SheA haemolytic phenotype (2003)

Lysogeny has previously been described in the entomopathogenic bacteria of the genus Xenorhabdus. Screening of a X. nematophila prophage DNA library on blood agar resulted in the identification of a 5.7-kb locus that caused a haemolytic phenotype when cloned in Escherichia coli, but not in the E. coli sheA null mutant, lacking the SheA cryptic haemolysin. This locus exhibited similarity to lysis genes from lambdoid phages. In particular, it encoded a functional holin able to complement a lambda Sam7 mutant. It is the second time that a locus encoding a functional holin is shown to reveal the SheA haemolytic phenotype in E. coli. The possible role of the holin in extracellular release of SheA is discussed.
Phase-shift tinnitus treatment: an open prospective clinical trial. (2007)

We report on a novel treatment for tinnitus using phase-shift pure tone sound treatment in patients with predominantly pure tone tinnitus. Thirty-five patients with pure tone tinnitus unresponsive to all previous treatment were enrolled in the study. All patients were treated three times in one week. If the patient noticed an improvement, the therapy was continued for six weeks with a home device customised to their specific treatment frequency. Twenty-one of the 35 patients (60%) responded positively to the initial therapy sessions. Tinnitus was assessed before treatment, after three in-office Tinnitus Phase-Out System therapy sessions, and after six weeks of home use of the Patient Treatment Device. The assessment instruments were a VAS loudness scale and the quality of life Tinnitus Questionnaire. Significant tinnitus reduction was obtained on VAS after three office Tinnitus Phase-Out System therapy sessions (before treatment: mean VAS = 6.4; after three therapy sessions: mean VAS = 4.9; p = 0.042) and after six weeks of home use of the Patient Treatment Device (mean VAS = 4.9; p = 0.005). When analysing the mean TQ score over treatment, there was a significant improvement in total score from pretreatment (mean TQ score = 41.9) to six weeks after home use of the Patient Treatment Device use (mean TQ score = 36.4) (p = 0.003). In view of the results obtained, the Phase-Out Treatment for tinnitus may provide the majority of patients with a significant improvement in their symptoms. Further evaluation, comparing this specific Phase-Out Treatment with more general noise stimulation treatment, will further specify the indications for this treatment option.
New Strategies for Prevention and Therapy of Cytomegalovirus Infection and Disease in Solid-Organ Transplant Recipients (2000)

In the past three decades since the inception of human organ transplantation, cytomegalovirus (CMV) has gained increasing clinical import because it is a common pathogen in the immunocompromised transplant recipient. Patients may suffer from severe manifestations of this infection along with the threat of potential fatality. Additionally, the dynamic evolution of immunosuppressive and antiviral agents has brought forth changes in the natural history of CMV infection and disease. Transplant physicians now face the daunting task of recognizing and managing the changing spectrum of CMV infection and its consequences in the organ recipient. For the microbiology laboratory, the emphasis has been geared toward the development of more sophisticated detection assays, including methods to detect emerging antiviral resistance. The discovery of novel antiviral chemotherapy is an important theme of clinical research. Investigations have also focused on preventative measures for CMV disease in the solid-organ transplant population. In all, while much has been achieved in the overall management of CMV infection, the current understanding of CMV pathogenesis and therapy still leaves much to be learned before success can be claimed.
Mini‐pig urinary bladder function: comparisons of <i>in vitro</i> anticholinergic responses and in vivo cystometry with drugs indicated for urinary incontinence (1990)

1. Studies of carbachol-induced contractions on mini-pig bladder tissue strips in vitro demonstrated that antagonist drugs produced a rank order of potency similar to that observed in guinea-pig tissues: propantheline approximately atropine greater than oxybutynin greater than dicyclomine greater than HHSiD greater than imipramine greater than terodiline approximately AF-DX 116. The drugs appeared to show competitive antagonism and the tissues exhibited resistance to complete cholinergic blockade. 2. Cytometry performed in vivo on awake mini-pigs also showed that i.v. cholinergic antagonists produced a dose-dependent depression of peak intravesical bladder pressure (PvesP) during slow filling of the bladder using urethral catheters, with a rank order of potency: atropine greater than oxybutynin approximately propantheline greater than HHSiD approximately dicyclomine greater than terodiline. Other parameters of the cystometrogram were unaffected by the antagonists, except for residual volume, which generally increased after drug treatment. 3. Hexahydrosiladifenidol (HHSiD), an ileal-selective competitive muscarinic antagonist, was about as effective an antagonist as the clinically useful drugs oxybutynin or dicyclomine, both in vitro and in vivo, suggesting that HHSiD may have useful therapeutic effects for the treatment of urinary incontinence. 4. Correlation of the rank order of potency for muscarinic antagonism between mini-pigs and guinea-pigs was very high in vitro (r = 0.97, P less than 0.05), as was the correlation among the drugs for their ability to depress PvesP of the cystometrogram in vivo (r = 0.89, P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Homocysteine metabolism and various consequences of folate deficiency (2006)

Homocysteine is a neurotoxic non-proteinogenic amino acid, an abnormal increase of which in plasma has been implicated in many pathological conditions including cardiovascular diseases, neural tube defects and is now recognized and Alzheimer's disease. Homocysteine elimination is regulated by the transmethylation and the transsulfuration pathways and is modulated by folate, a member of the B-vitamin family. A metabolic product of folate, 5 methyltetrahydrofolate, provides a methyl group that is used to reconvert homocysteine back to methionine through the transmethylation pathway. The efficiency of folate metabolism has an impact on the availability of S-adenosylmethionine (SAM), a compound that is known to activate homocysteine flux through the transsulfuration pathway. SAM is also necessary for utilization of the antioxidant glutathione via glutathione S-transferase. In this review, I will elaborate on different biochemical reactions that are implicated in the regulation of homocysteine elimination through the transmethylation and the transsulfuration pathways and on various consequences of folate deficiency on homocysteine metabolism.
Sugar Detection in Adulterated Honey via Fiber Optic Displacement Sensor for Food Industrial Applications (2015)

A fiber optic displacement sensor (FODS) using a transmission technique was developed to detect sugar contents in honey. This was achieved by measuring the output signal of non- and adulterated honey with different addition percentage volumes of sugar (fructose and glucose). Five types of honey samples were adulterated with different percentages of fructose and glucose ranging from 0% to 10%. Blue diode laser at 435 nm was used as a light source in this FODS. The performance of sensor showed that the voltage signal linearly increased with the concentration of adulteration of sugar. In contrast, the refractive index of the adulterated honey is found decreasing with the concentration of sugar. This means the higher sugar contents in adulterated honey the lower is the refractive index leading to high transmission in FODS. Thus, FODS based on a transmission technique has a potential to detect the sugar content in adulterated honey. The simplicity, faster, and cost effective made FODS as a promising technique for food industry.
Conversion of methanol to hydrocarbons over zeolite ZSM-23 (MTT): exceptional effects of particle size on catalyst lifetime (2017)

A variety of synthetic procedures have been used to obtain zeolite ZSM-23 (MTT) catalysts with crystallite sizes ranging from the micrometer to nanometer scale. When the acidic zeolite is used as a catalyst for the methanol to hydrocarbon (MTH) reaction, the catalytic lifetime is dramatically influenced by the crystallite shape and size.
Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control (2009)

The presented results may help to better understand the interaction of influenza virus with its receptor(s) and to identify new therapeutic targets for drug development.
A Discrete perceptual impact evaluation quality assessment framework for IPTV services (2010)

Network impairments are unpredictable and highly destructive to the perceptual quality of media content in the IPTV content distribution networks. As a result the existing network QoS based assessment methodologies are not adequate for the IPTV QoE assessment which determines the overall acceptability of a service as perceived by the end user. A discrete perceptual impact evaluation quality assessment framework (DEQA) is introduced in this paper. The proposed framework enables a real-time, non-intrusive assessment service by efficiently recognising and assessing the individual IPTV quality violation events in the distribution network. The discrete perceptual impacts to a media session are aggregated for the overall user level quality evaluation. With its deployment scheme, the DEQA framework also facilitates efficient network diagnosis and QoE management. Recent work on realising the functions of the framework is also presented.
Robust vanishing point estimation for driver assistance (2006)

This paper presents an architecture for real-time vanishing point estimation for driver assistance applications. It consists of a data-driven estimation and a model-based filtering module. The data-driven estimation algorithm is based on line-segments that are assumed to be calculated in an independent preprocessing stage. Model-based filtering is achieved by a Kalman filter that operates on the results of the data-driven processing step. The robustness of the overall estimation is significantly increased by online adaptation of the parameters of both, the data-driven as well as the model-driven processing units. The design of the feedback loop assures that no instable system states occur. The resulting architecture provides robust vanishing point estimation in a wide variety of environmental conditions
Spectral analysis of lung cancer serum using fluorescence and Raman spectroscopy (2006)

Spectral changes of lung cancer serum in the process of tumor evolution was investigated in this study. We kept close watch on the tumor progression of a group of patients, and measured their serum spectra using 488.0nm and 514.5nm excitation of an Ar-ion laser once a week. There was no apparent change observed in fluorescence spectrum in different period. However, the relative intensity of three Raman peaks (mode A, B and C) decreased every week later. For quantitative analysis of such changes, a parameter Ir (relative intensity of C Raman peak) was introduced and Ir-value was calculated. Calculation showed that Ir-value was degressive with tumor evolution, but β (Ir5145 /Ir4880) varied irregularly. To the end, no Raman peak was observed. We assumed that three Raman peaks were derived from beta carotene. It indicated that the content of beta carotene decreased with the aggravation of lung cancer.
Conjugated linoleic acid. A powerful anticarcinogen from animal fat sources (1994)

Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers of linoleic acid, which is found preferentially in dairy products and meat. Preliminary studies indicate that CLA is a powerful anticarcinogen in the rat mammary tumor model with an effective range of 0.1-1% in the diet. This protective effect of CLA is noted even when exposure is limited to the time of weaning to carcinogen administration. The timing of this treatment corresponds to maturation of the mammary gland to the adult stage, suggesting that CLA may have a direct effect in reducing the cancer risk of the target organ. Of the vast number of naturally occurring substances that have been demonstrated to have anticarcinogenic activity in experimental models, all but a handful of them are of plant origin. Conjugated linoleic acid is unique because it is present in food from animal sources, and its anticancer efficacy is expressed at concentrations close to human consumption levels.
End-to-End Mobility Management: A Two-Phase Deployment Scheme for Personal Use. (2004)

Abstract-In this paper, we focus on mobility management and its deployment issues. There are many proposed mobility management mechanisms. However, the deployment of such mobility management has been facing difficulties and it is slower than it is initially expected. Therefore, we argue the issues to boost the deployment process. We especially focus on the end-toend approach, which can be mainly achieved by higher-layer implementation. With the end-to-end mobility management approach, we can explicitly separate the concept of session management and location management. Making use of this property of the end-to-end approach, we introduce a two-phase deployment scheme, which intends to avoid the use of static global address and the involvement of the multiple administrative domains to assist the personal use. I.
Distribution and Characteristics of the Catalases of Lactobacillaceae (1965)

Johnston, M. A. (Cornell University, Ithaca, N.Y.), and E. A. Delwiche. Distribution and characteristics of the catalases of Lactobacillaceae. J. Bacteriol. 90:347-351. 1965.-Certain strains of lactobacilli and pediococci incorporated hematin during growth, with the concomitant formation of cyanide- and azide-sensitive catalase. Three of five strains of lactobacilli and five of 25 strains of pediococci were capable of this biosynthesis. The pediococci required the heme component of blood, whereas the lactobacilli could incorporate the heme component in the form of purified and solubilized hemin or from blood. In all cases where inhibitor-sensitive enzyme was produced, it was accompanied by the production of inhibitor-insensitive enzyme. In the absence of hematin, only insensitive enzyme was obtained. Two catalase-positive strains of Streptococcus faecalis were found incapable of the synthesis of a heme-type enzyme, as was one member of the genus Leuconostoc. Iron and manganese in the growth medium stimulated the production of the insensitive catalase, but significant quantities of these metals could not be found in a purified enzyme preparation obtained from Lactobacillus plantarum. Aeration had little or no effect on growth, but it consistently doubled the amount of cyanide- and azide-resistant catalase. By means of conventional enzyme fractionation techniques, it was possible to separate the two different enzymes present in the cell-free extract of a strain of Pediococcus homari which had been grown in the presence of blood.
<i>Rhizobium leguminosarum</i> as a plant growth-promoting rhizobacterium: direct growth promotion of canola and lettuce (1996)

Early seedling root growth of the nonlegumes canola (Brassica campestris cv. Tobin, Brassica napus cv. Westar) and lettuce (Lactuca sativa cv. Grand Rapids) was significantly promoted by inoculation of seeds with certain strains of Rhizobium leguminosarum, including nitrogen- and nonnitrogen-fixing derivatives under gnotobiotic conditions. The growth-promotive effect appears to be direct, with possible involvement of the plant growth regulators indole-3-acetic acid and cytokinin. Auxotrophic Rhizobium mutants requiring tryptophan or adenosine (precursors for indole-3-acetic acid and demonstrate a new facet of the Rhizobium-plant relationship and that Rhizobium leguminosarum can be considered a plant growth-promoting rhizobacterium (PGPR).
Mass production of industrial tunnel oxide passivated contacts (i‐TOPCon) silicon solar cells with average efficiency over 23% and modules over 345 W (2019)

Abstract We present an industrial tunnel oxide passivated contacts (i‐TOPCon) bifacial crystalline silicon (c‐Si) solar cell based on large‐area n ‐type substrate. The interfacial thin SiO 2 is thermally growth and in situ capped by an intrinsic poly‐Si layer deposited by low‐pressure chemical vapor deposition (LPCVD). The intrinsic poly‐Si layer is doped in an industrial POCl 3 diffusion furnace to form the n + poly‐Si at the rear, which shows an excellent surface passivation characteristics with J 0 = 2.6 fA/cm 2 when passivated by a SiN x :H layer deposited by plasma‐enhanced chemical vapor deposition (PECVD). With an industrial fabrication process, the cells are manufactured with screen‐printed front and rear metallization, using large‐area 6‐in. n ‐type Czochralski (Cz) Si wafers. We demonstrate an average front‐side efficiency greater than 23% and an open‐circuit voltage V oc greater than 700 mV. These results are based on more than 20 000 pieces of cells from mass production on a single day, in an old conventional multicrystalline silicon (mc‐Si) Al‐back surface field (BSF) cell workshop, which has been upgraded to i‐TOPCon process. The best cell efficiency reaches 23.57%, as independently confirmed by Fraunhofer CalLab. A median module power greater than 345 W and a best module power greater than 355 W are demonstrated with double‐glass bifacial i‐TOPCon modules consisting of 120 pieces of half‐cut 161.7 mm pseudosquare i‐TOPCon cells with nine busbars.
Histamine-Stimulated Cytokine Secretion from Human Conjunctival Epithelial Cells: Inhibition by the Histamine H<sub>1</sub> Antagonist Emedastine (1998)

The present studies demonstrate that histamine induces the secretion of IL-6, IL-8 and GM-CSF from human conjunctival epithelial cells in a dose- and time-dependent manner. The histamine antagonists emedastine (H1), ranitidine (H2) and thioperamide (H3) were evaluated for their ability to inhibit secretion of these cytokines. Emedastine potently inhibited histamine-induced IL-6, IL-8 and GM-CSF secretion with mean IC50 values of 2.23, 3.42 and 1.50 nM, respectively. Ranitidine and thioperamide failed to inhibit cytokine secretion over a wide dose range. These data suggest that mast cell derived histamine may stimulate inflammatory cytokine production in allergic conjunctivitis via activation of epithelial cell H1 receptors. The histamine H1 antagonist emedastine potently inhibits this response.