gebhart/patrepeval huggingface dataset:
EMLA cream in the treatment of post-herpetic neuralgia. Efficacy and pharmacokinetic profile (1989)

The analgesic efficacy of 5% EMLA cream (5 or 10 g) when applied for 24 h periods was evaluated in 5 female and 7 male patients (mean age 69 years, range 50–85 years) with refractory post-herpetic neuralgia (PHN). Mean visual analogue pain intensity scores for all patients were significantly improved 6 h after application (P < 0.05). In a subgroup of patients with facial PHN receiving EMLA cream, 5 g (n = 4), there were significant improvements in pain intensity scores at 6 h (P < 0.05), 8 h (P < 0.01) and 10 h (P < 0.01) after application. Plasma lignocaine and plasma prilocaine concentrations were well below potentially toxic levels in all patients after application.
Object Detection Using Keygraphs (2013)

We propose a new framework for object detection based on a generalization of the keypoint correspondence framework. This framework is based on replacing keypoints by keygraphs, i.e. isomorph directed graphs whose vertices are keypoints, in order to explore relative and structural information. Unlike similar works in the literature, we deal directly with graphs in the entire pipeline: we search for graph correspondences instead of searching for individual point correspondences and then building graph correspondences from them afterwards. We also estimate the pose from graph correspondences instead of falling back to point correspondences through a voting table. The contributions of this paper are the proposed framework and an implementation that properly handles its inherent issues of loss of locality and combinatorial explosion, showing its viability for real-time applications. In particular, we introduce the novel concept of keytuples to solve a running time issue. The accuracy of the implementation is shown by results of over 800 experiments with a well-known database of images. The speed is illustrated by real-time tracking with two different cameras in ordinary hardware.
A Novel Role for IgG-Fc (1995)

Human type 1 Fc gamma receptors (Fc gamma RI) bind with high affinity (Kd = approximately 10(-9) M) Fc regions of monomeric IgG1 and IgG3. As demonstrated in this report, interaction of IgG-Fc with the ligand binding site on Fc gamma RI alters its capacity for aggregation-dependent signaling. This Fc-dependence was demonstrated in normal monocytes and U937-10.6 cells exposed to monomeric IgG and then to anti-Fc gamma RI F(ab')2 that cross-link the receptor. Using O2- production to measure cell signaling, we found that binding by high affinity IgGs of various species, as well as by murine hybrid IgGs containing only one high affinity heavy chain, resulted in a marked increase in Fc gamma RI-mediated signaling. Preaggregated Fc gamma RI/IgG had a ratio of one. IgG binding after aggregation of unligated Fc gamma RI did not restore signaling. Dose responses indicated that concentrations of IgG that saturated Fc gamma RI optimized transductional activity. The inclusion of unligated with ligated Fc gamma RI in aggregates depressed activity, indicating a lack of trans-activation of unligated Fc gamma RI. Significantly, IgG-binding markedly increased aggregation-dependent tyrosine phosphorylation of Fc gamma RI gamma-chains and the association of tyrosine phosphorylated Syk. Thus, the consequences of IgG-Fc binding were increases in aggregation-dependent phosphorylation of Fc gamma RI gamma-chains, recruitment of pp72Syk to Fc gamma RI, and signaling of the NADPH oxidase pathway.
Poly(amidoamine)s: Past, present, and perspectives (2013)

Poly(amidoamine)s (PAAs) are a family of synthetic polymers obtained by stepwise polyaddition of prim ‐ or sec ‐amines to bisacrylamides. Nearly all conceivable bisacrylamides and prim ‐ or sec ‐amines can be employed as monomers endowing PAAs of a structural versatility nearly unique among stepwise polyaddition polymers. PAAs are degradable in aqueous media, including physiological fluids. Many of them are remarkably biocompatible notwithstanding their cationic character. PAAs are per se highly functional polymers and, in addition, can be further functionalized giving rise to an endless variety of polymeric structures meeting the requisites for applications in such apparently disparate fields as inorganic water pollutants scavengers, sensors, drug and protein intracellular carriers, transfection promoters, peptidomimetic antiviral and antimalarial agents. In this review, the unique chemistry of PAAs is discussed and a vast library of PAA structures and PAA applications from the beginning to the present days reported. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 2319–2353
The evaluation of NIR-absorbing porphyrin derivatives as contrast agents in photoacoustic imaging (2013)

Six free base tetrapyrrolic chromophores, three quinoline-annulated porphyrins and three morpholinobacteriochlorins, that absorb light in the near-IR range and possess, in comparison to regular porphyrins, unusually low fluorescence emission and (1)O2 quantum yields were tested with respect to their efficacy as novel molecular photo-acoustic imaging contrast agents in a tissue phantom, providing an up to ∼2.5-fold contrast enhancement over that of the benchmark contrast agent ICG. The testing protocol compares the photoacoustic signal output strength upon absorption of approximately the same light energy. Some relationships between photophysical parameters of the dyes and the resulting photoacoustic signal strength could be derived.
Myelin basic protein, an autoantigen in multiple sclerosis, is selectively processed by human trypsin 4 (2005)

Demyelination, the proteolytic degradation of the major membrane protein in central nervous system, myelin, is involved in many neurodegenerative diseases. In the present in vitro study the proteolytic actions of calpain, human trypsin 1 and human trypsin 4 were compared on lipid bound and free human myelin basic proteins as substrates. The fragments formed were identified by using N-terminal amino acid sequencing and mass spectrometry. The analysis of the degradation products showed that of these three proteases human trypsin 4 cleaved myelin basic protein most specifically. It selectively cleaves the Arg79-Thr80 and Arg97-Thr98 peptide bonds in the lipid bound form of human myelin basic protein. Based on this information we synthesized peptide IVTPRTPPPSQ that corresponds to sequence region 93-103 of myelin basic protein and contains one of its two trypsin 4 cleavage sites, Arg97-Thr98. Studies on the hydrolysis of this synthetic peptide by trypsin 4 have confirmed that the Arg97-Thr98 peptide bond is highly susceptible to trypsin 4. What may lend biological interest to this finding is that the major autoantibodies found in patients with multiple sclerosis recognize sequence 85-96 of the protein. Our results suggest that human trypsin 4 may be one of the candidate proteases involved in the pathomechanism of multiple sclerosis.
Permanent magnet-assisted omnidirectional ball drive (2016)

We present an omnidirectional ball wheel drive design that utilizes a permanent magnet as the drive roller to generate the contact force. Particularly interesting for novel human-mobile robot interaction scenarios where the users are expected to physically interact with many palm-sized robots, our design combines simplicity, low cost and compactness. We first detail our design and explain its key parameters. Then, we present our implementation and compare it with an omniwheel drive built with identical conditions and similar cost. Finally, we elaborate on the main advantages and drawbacks of our design.
Facile intermolecular activation of carbon-hydrogen bonds in methane and other hydrocarbons and silicon-hydrogen bonds in silanes with the iridium(III) complex Cp*(PMe3)Ir(CH3)(OTf) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile intermolecular activation of carbon-hydrogen bonds in methane and other hydrocarbons and silicon-hydrogen bonds in silanes with the iridium(III) complex Cp*(PMe3)Ir(CH3)(OTf)Peter Burger and Robert G. BergmanCite this: J. Am. Chem. Soc. 1993, 115, 22, 10462–10463Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/ja00075a113https://doi.org/10.1021/ja00075a113research-articleACS PublicationsRequest reuse permissionsArticle Views1945Altmetric-Citations248LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Associations between types of lameness and fertility (1989)

Four hundred and twenty-seven cases of first-reported foot lameness were recorded in 17 dairy herds in Somerset during the winter housing period. Lameness was classified into three categories: sole ulceration, digital disease (white line abscess, foreign bodies in the sole and pricked or punctured sole), and interdigital disease (lesions of the skin between claws and heel including foul in the foot, interdigital fibroma and dermatitis). In addition, a 'clinical effect score' was calculated to take account of the severity of lameness, the structures involved and the time for which the cows were clinically affected. The fertility records of lame cows were compared with those of the healthy cows nearest in parity and stage of lactation. In the lame cows the interval from calving to first service was four days longer, and the interval from calving to conception was 14 days longer than in the control cows, the pregnancy rate to first service was 46 per cent (controls 56 per cent), 2.14 services were required per conception (controls 1.72) and 16 per cent of lame cows were culled (controls 5 per cent). Lameness, first reported in the period 36 to 70 days after calving, was associated with a significant (P less than 0.01) increase in the interval from calving to first service of eight days; and sole ulceration, in the period 71 to 120 days after calving, was associated with an increase of 11 days (P less than 0.05). Lameness in all periods up to 120 days after calving was associated with significantly increased intervals from calving to conception (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Studies on the mechanisms of hypersensitivity phenomena. XV. Enhancement of passive sensitization of human leukocytes by heparin. (1967)

Summary Passive sensitization, in vitro , of human leukocytes with serum from ragweed-sensitive individuals is enhanced by heparin ( ca. 10 -6 M). The potentiating effect of heparin is even more evident in the presence of 4 × 10 -3 M ethylenediaminetetraacetate (EDTA). The synergistic action of the two compounds on passive sensitization suggests different sites or mechanisms of enhancement. A suggested mode of action involves a net increase in negatively charged membrane sites capable of interaction with cationic residues on the immunoglobulin molecules. Unlike EDTA, heparin does not influence the cellular histamine release mechanism. The available data suggest that the enhancing effect of heparin may be independent of the blood clotting mechanism. However, the ability of heparin to augment passive sensitization under in vitro conditions, is shared by other mucopolysaccharides with anticoagulant activity.
Local Plane-Wave Imaging of GPR Data (2003)

Local Plane-Wave processing is used to image synthetic Ground Penetrating Radar (GPR) data in a non-homogeneous background. Numerically calculated Green’s functions are used to back propagate the data down to a Green’s function node in the center of the region to be imaged. From the Green’s function node a plane-wave approximation is used to propagate the data over a local image. The local images are compared with images obtained from diffraction stack processing. The effect of the irregular wavenumber sampling on the point spread function is illustrated. The local image using all corrections shows a great reduction in image distortion compared to diffraction stack processing.
Response to Japanese College EFL Learners' Difficulties in SLA (1996)

journal article
Low dissipation current GaAs prescaler IC (1986)

A 1 GHz variable modulus freqency divider with very low dissipation current has been developed. Using a high-transconductance (200–250 mS/mm) FET by Pt burying technology and series gating source-coupled FET logic, the dissipation current of the fabricated IC was reduced to 3.2 mA at 1 GHz operation.
Relative 3D Reconstruction Using Multiple Uncalibrated Images (1995)

In this article we show how relative 3D reconstruction from point correspondences of multiple uncalibrated images can be achieved through reference points. The original contributions with respect to related works in the field are mainly a direct global method for relative 3D reconstruction and a geometric method to select a correct set of reference points among all im age points. Experimental results from both simulated and real image sequences are presented, and robustness of the method and reconstruction precision of the results are discussed.
Characterization of sub-nm AlO<inf>x</inf> and LaO<inf>x</inf> capping layers on high-k gate stack film systems using VuV (&#x03BB;&#x003D;120 nm) reflectivity (2010)

This paper details the use of vacuum ultraviolet (120 nm <; λ <; 800 nm) spectroscopic reflectivity to simultaneously measure AlO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> and LaO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> capping layers and the underlying high-k film stack system. It is demonstrated that the sensitivity of the method originates in the VuV portion of the spectra where absorption of these materials contributes significantly to the overall optical response. As a result, the reflectivity in the VuV region accurately resolves sub-nm changes in these capping layer thicknesses, while data in the Vis-uV (190 <; λ <; 800 nm) wavelengths show negligible differences. The extracted physical thicknesses are shown to trend consistently with the EOT and V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">fb</sub> data from identically prepared MOSCAP samples, thus highlighting this method as a suitable candidate for in-line metrology of sub-nm capping layers on high-k film stacks.
Population Studies of Formica Exsectoides Forel (1938)

The Eastern mound building ant, Formica exsectoides Forel, has been widely reported over the Northeastern United States, and has been the subject of many studies by Andrews, McCook, Pierson and Wheeler, and scattered accounts from others. Andrews' studies have been largely conducted in Maryland. The insect is present in numbers, in widely separated areas in the State, but no complete survey has been made to ascertain its exact distribution. North of Baltimore, in Baltimore County, there are many mounds. In Prince George's and Montgomery Counties, in the northwestern corner of the former county and adjacent parts of Montgomery County, there is a large area inhabited by this insect. A single colony was located almost at the summit of Round Top, an isolated spur at Hancock, Washington County, with an elevation of approximately 1400 feet.
A tunable bandpass filter based on varactor loaded split‐ring resonators (2009)

Abstract This article presents an electronically tunable varactor‐loaded microstrip bandpass filter based on the planar split ring resonators (SRRs). The varactor is a reverse‐biased semiconductor diode, and is connected between the concentric rings of the SRR. An individual varactor loaded SRR based bandpass tunable filter module is analyzed. Then a third order tunable filter with 2% fractional bandwidth and a tuning range from 2.11 to 2.34 GHz is assembled from basic filter modules. A prototype filter is designed, fabricated and tested. The maximum tuning range of the prototype filter is 10.2% and the size of the filter is reduced by a factor of 3.5 compared to a coupled line filter. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2394–2396, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24641
Supercooperativity in platelet aggregation: Substituted pyridyl isoxazoles, a new class of supercooperative platelet aggregation inhibitors (1994)

The phenomenon of supercooperativity in platelet aggregation is manifested by the occurrence of clear-cut thresholds in dose-response relationships; in such cases the Hill coefficient has unusually high values. Approximation, by the Hill equation, of the relationship of the rate of arachidonate-induced platelet aggregation to the concentrations of either the inducer or inhibitors such as substituted pyridyl isoxazoles (synthesized by us), indomethacin, and pinane thromboxane A2, demonstrated that the Hill coefficients ranged from 30 to 100. 3-(3-Pyridyl)-5-phenylisoxazole, which exhibited maximal anti-aggregatory activity among the synthesized compounds, inhibited neither cyclooxygenase nor thromboxane synthase. The compounds affected the signal transduction pathway at/or posterior to the stage of thromboxane A2 reception.
Dynamic behavior of dislocations in InAs: In comparison with III–V compounds and other semiconductors (1998)

The dynamic behavior of α and β dislocations in both undoped and impurity-doped InAs crystals is investigated as a function of stress and temperature by means of the etch pit technique. Suppression of the generation of dislocations from a surface scratch is found in S doped InAs, which is interpreted in terms of dislocation locking due to impurity clusters and/or impurity-defect complexes as has been observed in other III–V compounds. α dislocations move faster than β dislocations in the undoped and impurity-doped InAs. S donors reduce the velocities of both α and β dislocations. On the other hand, Zn acceptors enhance the velocity of α dislocations and reduce the velocity of β dislocations. Such features are related to an electronic state of the dislocations in the elementary process of the motion. The measured velocities are expressed using a simple empirical equation as a function of stress and temperature in the same manner as for other semiconductors. The linear dependence of the activation energies for dislocation motion on the band gap energy shows a clear distinction dependent on the group of semiconductors, i.e., the elemental and IV–IV compound, III–V compound, and II–VI compound.
<title>"Measurement Of Laser Beam Spreading In Biological Tissue Scattering"</title> (1987)

Attempts to model the thermal response of biological tissue to laser irradiation require an accurate description of the distribution of the light inside the tissue. This is difficult to describe theoretically because multiple scattering causes beam broadening. The Kubelka-Munk model is based on a model of two diffuse fluxes traveling in the forward and backward directions. This is unlike the directional laser source to be modeled. Multiple scattering theories are complex and add little intuitive insight to the light's behavior in the tissue. Our approach is to measure the growth of the beam as it is absorbed and scattered through our principal target, atheromatous plaque. We will describe an optical system that allows quantitative measurement of the 1/e<sup>2</sup> spot size as laser light is scattered in arterial plaque samples. The input beams used were: a) collimated lmm direct output from a laser and b) the diverging output of an optical fiber. The measurement is made by imaging the exit face of the tissue onto a scanning slit detector with unit magnification. By compressing the sample to calibrated thicknesses, readjusting the imaging to retain unit magnification, we obtain plots of exit spot size versus tissue thickness. The data indicate that the spot expands linearly as the sample's thickness is increased. However, the rate of beam expansion varied with different tissue samples. The linear beam expansion seen is in disagreement with the exponential growth previously assumed.
Pneumovirus in Dogs with Acute Respiratory Disease (2010)

To determine which respiratory viruses circulate among confined dogs, we analyzed nasal and pharyngeal swab specimens from shelter dogs with acute respiratory disease. An unknown virus was isolated. Monoclonal antibody testing indicated that it was probably a pneumovirus. PCR and sequence analysis indicated that it was closely related to murine pneumovirus.
Extreme ultraviolet high harmonic generation and spectroscopy in solids (2015)

Dedicated to my
Correction for patient and organ movement in SPECT: application to exercise thallium-201 cardiac imaging. (1988)

We describe a technique for correction of artifacts in exercise 201Tl single photon emission computed tomography (SPECT) images arising from abrupt or gradual translational movement of the heart during acquisition. The procedure involves the tracking of the "center of the heart" in serial projection images using an algorithm which we call "diverging squares". Each projection image is then realigned in the x-y plane so that the heart center conforms to the projected position of a fixed point in space. The shifted projections are reconstructed using the normal filtered backprojection algorithm. In validation studies, the motion correction procedure successfully eliminated movement artifacts in a heart phantom. Image quality was also improved in over one-half of 36 exercise thallium patient studies. The corrected images had smoother and more continuous left ventricular walls, greater clarity of the left ventricular cavity, and reduced streak artifacts. Rest injected or redistribution images, however, were often made worse, due to reduced heart to liver activity ratios and poor tracking of the heart center. Analysis of curves of heart position versus projection angle suggests that translation of the heart is common during imaging after exercise, and results from both abrupt patient movements, and a gradual upward shift of the heart. Our motion correction technique appears to represent a promising new approach for elimination of movement artifacts and enhancement of resolution in exercise 201Tl cardiac SPECT images.