gebhart/patrepeval huggingface dataset:
The Effects of Subdiaphragmatic Vagotomy in Rats With Ventromedial Hypothalamic Obesity (1977)

The present study investigated the effects of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic (VMH) lesions and obesity. Vagotomy or sham-vagotomy was performed two weeks after VMH lesions and rats were observed for 4 more weeks. Complete vagotomy reversed the VMH obesity, lowered serum insulin, lowered basal gastric acid and blocked the secretion of gastric acid after stimulation of the cervical vagus. Pair-feeding of VMH-lesioned rats without vagotomy to the food intake of vagotomized animals also reversed the obesity, lowered serum insulin and lowered basal acid secretion, but it did not prevent the rise in acid after vagal stimulation. These results suggest that subdiaphragmatic vagotomy reversed the obesity of VMH lesioned rats primarily by decreasing food intake. However, there was a positive correlation (r = .70) between the level of serum insulin and basal gastric acid in VMH lesioned rats which remained significant when the effects of food intake were held constant (partial correlation coefficient = 0.449). This supports the possibility that ventromedial hypothalamic injury is followed by enhanced vagal activity and that the vagus may play an important part in the hyperinsulinemia of VMH obesity.
Control of voltage stability using sensitivity analysis (1992)

The effects of static compensation on the voltage stability boundary are investigated. For a class of voltage instabilities which correspond to static bifurcations of load flow equations, minimum singular values of the Jacobian matrix and total generated reactive power are calculated as indicators of stability margin, and sensitivity methods are used for reactive support allocation. Improvement in stability margin under progressive loading was investigated on a 39-bus test system for different allocations and amounts of reactive support with reactive generation capabilities taken into account.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Dual wavelength chirped pulse amplification system (2000)

We demonstrate a Chirped Pulse Amplification system that simultaneously amplifies dual wavelength pulses from a two-colour oscillator in a single regenerative amplifier.
Pre-Clinical Evaluation of a Novel DNA Crosslinking Agent, Bo-1055 in B-Cell Lymphoma (2014)

Abstract Some B-cell lymphoma including mantle cell lymphoma (MCL) and diffuse large B-cell lymphoma (DLBCL) remain incurable using conventional chemotherapeutic approaches. Therefore it is important that new treatment strategies be developed. We have evaluated the efficacy of a number of novel, third generation, DNA-directed alkylating agents that have DNA specific binding domain by linking DNA-affinic molecules to N-mustard pharmacophore via a urea, carbamate or hydrazinecarboxamide linker (Kapuriya et al. Bioorganic & Medicinal Chem. 19:471–485; 2011). One of these, the water-soluble ureidomustine BO-1055, was screened for toxicity against a panel of human lymphoma cell lines including MCL (JEKO-1, Z-138, HBL-2), DLBCL (OCILy10, OCILy19) and a spontaneous murine B-cell lymphoma. We also screened BO1055 against a panel of normal human cells including mesenchymal stromal cells (IC50 >10uM), bone marrow-derived endothelium (IC50 >10uM) lung basal epithelium, bronchial epithelium and myofibroblasts (IC50s >10uM) and purified cord blood CD34+ cells in suspension culture or colony-forming assay (for hematopoietic progenitor cells) (IC50 >10uM) and in cobblestone area-forming assay (for hematopoietic stem cells) (IC50 9.1uM). The mean IC50±SD (uM) in MCL cell lines was JEKO-1 (0.266±0.27), Z-138 (0.182±0.15), HBL2 (0.161±0.34), In DLBCL lines OCILy10 (0.117±0.21), OCILy19 (0.287±0.17) and murine B-cell lymphoma (0.463±0.39). Our results indicated that BO-1055 has a significant therapeutic window (50-100-fold) between its toxicity against human B-cell lymphomas compared to various normal human cell types. We evaluated BO-1055 cardiotoxicity in the HL-1 cardiomyocyte line and observed a 227-fold less cytotoxicity compared to Doxorubicin. Treatment with BO-1055 resulted in accumulation of cells in S-phase and up-regulation of proteins involved in DNA repair [MRE11, p-P95/NBS1 (ser343), RAD50, p-ATR (ser428)] while Bcl-6, an important B-cell lymphoma biomarker, was down-regulated. Xenograft experiments in NSG mice bearing JEKO-1 GFP/luciferase+ tumors treated with BO-1055 (30mg/kg) 3x/week showed complete tumor remission after 2 weeks of treatment as monitored by luciferase image. Our results suggest that BO-1055 has potent activity against B-cell lymphoma and present a strong rationale for its further therapeutic development as an alkylating agent due to his low toxicity against normal tissue and high toxicity against hematopoietic tumors. Disclosures No relevant conflicts of interest to declare.
Cánovas o el hombre de eﬆado (1933)

La Biblioteca Virtual de la Provincia de Málaga, es un proyecto puesto en marcha por la Diputación de Málaga, con el objetivo de reunir, preservar y difundir a través de Internet, las colecciones digitales del patrimonio bibliográfico malagueño.
Balloon Tag: (in)visible marker which tells who's who (2002)

This paper introduces the Balloon Tag, an infrared LED tag whose ID is detected and read by an ordinary video camera. Different from conventional visual tag systems, signal patterns cannot be seen by human eyes and don't annoy the user while the relative position of the tag from the camera can be recognized as the barcode ID tag. The authors combined the idea of the Balloon Tag with wireless communication over Bluetooth which would become widely used with wearable computers. With the proposed algorithm, the Balloon Tag receiver chooses the nearest Bluetooth transmitter. Then, a part of the Bluetooth device address (BD ADDR) is obtained to make a connection. As a result, the receiver can easily select the most important person to communicate with.
Electron Beam Curing of Polymer Matrix Composites - CRADA Final Report (1997)

The major cost driver in manufacturing polymer matrix composite (PMC) parts and structures, and one of the elements having the greatest effect on their quality and performance, is the standard thermal cure process. Thermal curing of PMCs requires long cure times and high energy consumption, creates residual thermal stresses in the part, produces volatile toxic by-products, and requires expensive tooling that is tolerant of the high cure temperatures.
THE PREPARATION OF β-AMINOPROPIOPHENONE. (1919)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE PREPARATION OF β-AMINOPROPIOPHENONE.William J. Hale and Edgar C. BrittonCite this: J. Am. Chem. Soc. 1919, 41, 5, 841–847Publication Date (Print):May 1, 1919Publication History Published online1 May 2002Published inissue 1 May 1919https://pubs.acs.org/doi/10.1021/ja02226a017https://doi.org/10.1021/ja02226a017research-articleACS PublicationsRequest reuse permissionsArticle Views413Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<title>Survey of maneuvering target tracking: dynamic models</title> (2000)

This is the first part of a series of papers that provide a comprehensive and up-to-date survey of the problems and techniques of tracking maneuvering targets in the absence of the so-called measurement-origin uncertainty. It surveys the various mathematical models of target dynamics proposed for maneuvering target tracking, including 2D and 3D maneuver models as well as coordinate-uncoupled generic models for target dynamics. This survey emphasizes the underlying ideas and assumptions of the models. Interrelationships among the models surveyed and insight to the pros and cons of the models are provided. Some material presented here has not appeared elsewhere.
Antidepressant efficacy of high-frequency transcranial magnetic stimulation over the left dorsolateral prefrontal cortex in double-blind sham-controlled designs: a meta-analysis (2008)

These findings show that high-frequency rTMS over the left DLPFC is superior to sham in the treatment of depression. The effect size is robust and comparable to at least a subset of commercially available antidepressant drug agents. Current limitations and future prospects are discussed.
Strained Si Channel MOSFETs with Embedded Silicon Carbon Formed by Solid Phase Epitaxy (2007)

Current drive enhancement is demonstrated in sub-40 nm NFETs with strained silicon carbon (Si:C) source and drain using a novel solid-phase epitaxy (SPE) technique for the first time. The very simple process uses no recess etch or epi deposition steps, adds minimal process cost, and can be easily integrated into a standard CMOS process. With a record high 1.65 at% substitutional C concentration in source and drain, 615 MPa uniaxial tensile stress was introduced in the channel, leading to a 35% improvement in electron mobility and 6% and 15% current drive increase in sub-40 and 200 nm channel length devices respectively.
A new derivation of least-squares-fitting principle for OFDM channel estimation (2006)

Many channel estimation and data detection algorithms of the orthogonal frequency division multiplexing (OFDM) system have been proposed. Some of these algorithms are based on the principle of linear minimum mean-square error (LMMSE) estimation, which is theoretically optimal. There are also some algorithms developed based on the least-squares-fitting (LSF) principle, which finds a regression polynomial to fit a block of tentative channel estimates in the least-squares sense. The LSF principle is a non-statistical approach, while the LMMSE algorithm is statistical and it needs to known or estimate the channel statistics like correlation matrices and signal-to-noise ratio (SNR). This letter proposes a novel viewpoint of the LSF principle. We show that the non-statistical LSF principle can be derived alternatively from the statistical LMMSE principle by eigenvector approximation. This constructs a link between these two principles. The mean-square estimation error (MSEE) analysis shows that there are common terms in the MSEE expressions of these two principles. This further validates the constructed link. Based on the derived link and MSEE analysis, we also give some characteristics and discussions of the LSF principle.
TOWARD AN ECOLOGICAL CLASSIFICATION OF SOIL BACTERIA (2007)

Although researchers have begun cataloging the incredible diversity of bacteria found in soil, we are largely unable to interpret this information in an ecological context, including which groups of bacteria are most abundant in different soils and why. With this study, we examined how the abundances of major soil bacterial phyla correspond to the biotic and abiotic characteristics of the soil environment to determine if they can be divided into ecologically meaningful categories. To do this, we collected 71 unique soil samples from a wide range of ecosystems across North America and looked for relationships between soil properties and the relative abundances of six dominant bacterial phyla (Acidobacteria, Bacteroidetes, Firmicutes, Actinobacteria, alpha-Proteobacteria, and the beta-Proteobacteria). Of the soil properties measured, net carbon (C) mineralization rate (an index of C availability) was the best predictor of phylum-level abundances. There was a negative correlation between Acidobacteria abundance and C mineralization rates (r2 = 0.26, P < 0.001), while the abundances of beta-Proteobacteria and Bacteroidetes were positively correlated with C mineralization rates (r2 = 0.35, P < 0.001 and r2 = 0.34, P < 0.001, respectively). These patterns were explored further using both experimental and meta-analytical approaches. We amended soil cores from a specific site with varying levels of sucrose over a 12-month period to maintain a gradient of elevated C availabilities. This experiment confirmed our survey results: there was a negative relationship between C amendment level and the abundance of Acidobacteria (r2 = 0.42, P < 0.01) and a positive relationship for both Bacteroidetes and beta-Proteobacteria (r2 = 0.38 and 0.70, respectively; P < 0.01 for each). Further support for a relationship between the relative abundances of these bacterial phyla and C availability was garnered from an analysis of published bacterial clone libraries from bulk and rhizosphere soils. Together our survey, experimental, and meta-analytical results suggest that certain bacterial phyla can be differentiated into copiotrophic and oligotrophic categories that correspond to the r- and K-selected categories used to describe the ecological attributes of plants and animals. By applying the copiotroph-oligotroph concept to soil microorganisms we can make specific predictions about the ecological attributes of various bacterial taxa and better understand the structure and function of soil bacterial communities.
Efficient semiclassical approach for time delays (2014)

The Wigner time delay, defined by the energy derivative of the total scattering phase shift, is an important spectral measure of an open quantum system characterising the duration of the scattering event. It is related to the trace of the Wigner-Smith matrix Q that also encodes other time-delay characteristics. For chaotic cavities, these exhibit universal fluctuations that are commonly described within random matrix theory. Here, we develop a new semiclassical approach to the time-delay matrix which is formulated in terms of the classical trajectories that connect the exterior and interior regions of the system. This approach is superior to previous treatments because it avoids the energy derivative. We demonstrate the method's efficiency by going beyond previous work in studying the time-delay statistics for chaotic cavities with perfectly connected leads. In particular, the universality for moment generating functions of the proper time-delays (eigenvalues of Q) is established up to third order in the inverse number of scattering channels for systems with and without time-reversal symmetry. Semiclassical results are then obtained for a further two orders. We also show the equivalence of random matrix and semiclassical results for the second moments and for the variance of the Wigner time delay at any channel number.
Non-destructive testing of through silicon vias by high-resolution X-ray/CT techniques (2012)

Detecting through silicon via (TSV) associated defects non-destructively immediately after the fabrication process, or in failure analysis is of great interest and is a challenge. This paper reports on the inspections of 5 to 30 μm diameter TSVs by the state-of-the-art, commercially available X-ray systems, exemplifying a generally preferred method for non-invasively identifying metallization defects in vias as well as in joining structures. The principle of X-ray imaging for TSV measurement is discussed and illustrated, and three dimensional TSV structures are reconstructed by computed tomography (CT). Methods to achieve high-resolution TSV X-ray imaging are discussed.
Evolution of wireless data services: IS-95 to cdma2000 (1998)

Existing IS-95-based CDMA systems support circuit-mode and packet-mode data services at a data rate limited to 9.6-14.4 kb/s. Fueled by the explosive growth of the Internet, applications and market opportunities are demanding that higher capacity, higher data rates, and advanced multimedia services be supported in the near future. The evolution of the IS-95 CDMA standard to higher data rates and more advanced services occurs in two steps. The first step, IS-95-B, is an enhancement to the IS-95-A standard and offers the highest possible performance without breaking current IS-95-A air interface design characteristics, thereby maintaining strict compatibility with existing base station hardware. The proposed standard will support a high data rate (64 kb/s) in both directions, to and from the mobile device. A new burst mode packet data service is defined to allow better interference management and capacity utilization. The second evolution step, cdma2000, provides next-generation capacity, data rates, and services. The cdma2000 system includes a greatly enhanced air interface supporting CDMA over wider bandwidths for improved capacity and higher data rates while also maintaining backward compatibility with existing IS-95 CDMA end-user devices. The cdma2000 system also includes a sophisticated MAC feature to effectively support very-high-data-rate services (up to 2 Mb/s) and multiple concurrent data and voice services. This article describes the design and performance of the high-data-rate service provided by second- and third-generation CDMA systems.
A Cross-Domain Augmentation-Based AI Learning Framework for In-Network Gesture Recognition (2021)

This article studies the problem of RFID-based gesture recognition, which is practically important in various human-computer interaction scenarios, for example, smart homes, intelligent logistics, and smart cities. However, the existing solutions normally suffer from two major limitations: the model-driven methods are sensitive to specific environmental factors, and usually do not adapt well to a complex scenario that is full of multipath; the data-driven methods normally need the collection of massive RFID training data, and deploying the model in the remote cloud leads to long response delay. To overcome the above limitations, this article proposes a cross-domain augmentation-based AI learning (CAL) framework in the context of cloud-edge computing. In the CAL framework, we can simulate massive RFID phase profiles by converting the computer vision data that contains the gesture movement information, instead of costing lots of manpower to actually collect RFID training data. The simulated RFID phase profiles are used to train an AI model in the high-performance cloud. Note that since many sources of this kind of computer vision data are available online, we actually do not even need any manpower to collect training data. To achieve time-efficient recognition, knowledge distillation is applied to get a light and accurate model, which is deployed at the edge side. Thus, recognition response delay can be significantly reduced because the edge server where the AI model is actually deployed is much closer to users than the cloud server. We use commercial off-the-shelf RFID, Kinect, a high-performance server, and a laptop to implement the CAL framework. Extensive experiments are conducted to evaluate the performance of CAL. The results reveal that gesture recognition accuracy of CAL can reach nearly 90 percent without collection of any RFID training data.
TDP-43 Mediates Degeneration in a Novel<i>Drosophila</i>Model of Disease Caused by Mutations in VCP/p97 (2010)

Inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD) is a dominantly inherited degenerative disorder caused by mutations in the valosin-containing protein (VCP7) gene. VCP (p97 in mouse, TER94 in Drosophila melanogaster, and CDC48 in Saccharomyces cerevisiae) is a highly conserved AAA(+) (ATPases associated with multiple cellular activities) ATPase that regulates a wide array of cellular processes. The mechanism of IBMPFD pathogenesis is unknown. To elucidate the pathogenic mechanism, we developed and characterized a Drosophila model of IBMPFD (mutant-VCP-related degeneration). Based on genetic screening of this model, we identified three RNA-binding proteins that dominantly suppressed degeneration; one of these was TBPH, the Drosophila homolog of TAR (trans-activating response region) DNA-binding protein 43 (TDP-43). Here we demonstrate that VCP and TDP-43 interact genetically and that disease-causing mutations in VCP lead to redistribution of TDP-43 to the cytoplasm in vitro and in vivo, replicating the major pathology observed in IBMPFD and other TDP-43 proteinopathies. We also demonstrate that TDP-43 redistribution from the nucleus to the cytoplasm is sufficient to induce cytotoxicity. Furthermore, we determined that a pathogenic mutation in TDP-43 promotes redistribution to the cytoplasm and enhances the genetic interaction with VCP. Together, our results show that degeneration associated with VCP mutations is mediated in part by toxic gain of function of TDP-43 in the cytoplasm. We suggest that these findings are likely relevant to the pathogenic mechanism of a broad array of TDP-43 proteinopathies, including frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Direct Screening of Blood by PCR and Pyrosequencing for a 16S rRNA Gene Target from Emergency Department and Intensive Care Unit Patients Being Evaluated for Bloodstream Infection (2015)

Here we compared the results of PCR/pyrosequencing to those of culture for detecting bacteria directly from blood. DNA was extracted from 1,130 blood samples from 913 patients suspected of bacteremia (enrollment criteria were physician-ordered blood culture and complete blood count [CBC]), and 102 controls (healthy blood donors). Real-time PCR assays for beta-globin and Universal 16S rRNA gene targets were performed on all 1,232 extracts. Specimens identified by Universal 16S rRNA gene PCR/pyrosequencing as containing staphylococci, streptococci, or enteric Gram-negative rods had target-specific PCR/pyrosequencing performed. Amplifiable beta-globin (melting temperature [Tm], 87.2°C ± 0.2°C) occurred in 99.1% (1,120/1,130) of patient extracts and 100% (102/102) of controls. Concordance between PCR/pyrosequencing and culture was 96.9% (1,085/1,120) for Universal 16S rRNA gene targets, with positivity rates of 9.4% (105/1,120) and 11.3% (126/1,120), respectively. Bacteria cultured included staphylococci (59/126, 46.8%), Gram-negative rods (34/126, 27%), streptococci (32/126, 25.4%), and a Gram-positive rod (1/126, 0.8%). All controls screened negative by PCR/pyrosequencing. Clinical performance characteristics (95% confidence interval [CI]) for Universal 16S rRNA gene PCR/pyrosequencing included sensitivity of 77.8% (69.5 to 84.7), specificity of 99.3% (98.6 to 99.7), positive predictive value (PPV) of 93.3% (86.8 to 97.3), and negative predictive value (NPV) of 97.2% (96.0 to 98.2). Bacteria were accurately identified in 77.8% (98/126) of culture-confirmed sepsis samples with Universal 16S PCR/pyrosequencing and in 76.4% (96/126) with follow-up target-specific PCR/pyrosequencing. The initial PCR/pyrosequencing took ∼5.5 h to complete or ∼7.5 h when including target-specific PCR/pyrosequencing compared to 27.9 ± 13.6 h for Gram stain or 81.6 ± 24.0 h for phenotypic identification. In summary, this molecular approach detected the causative bacteria in over three-quarters of all culture-confirmed cases of bacteremia directly from blood in significantly less time than standard culture but cannot be used to rule out infection.
The Sunset of a Great Life. (1929)

This study emphasizes the difficulty experienced even in ordinary arithmetic and algebra in reaching a common world-language.The only hope for rapid approach of uniformity in mathematical symbolism lies in international co'operation through representative committees.