gebhart/patrepeval huggingface dataset:
Biodistribution of ricin toxin A chain-monoclonal antibody 791T/36 immunotoxin and influence of hepatic blocking agents. (1987)

Immunotoxin constructed by conjugating ricin A chain to monoclonal antibody 791T/36 has a markedly altered biodistribution when compared to unconjugated antibody. This is principally manifest as hepatic uptake of immunotoxin which appears to be controlled by the ricin A chain (RTA) moiety. This was established by comparing the blood survival and organ distribution of immunotoxin with that of ricin A chain and free antibody using preparations in which either the RTA or antibody, alone or as components of the immunotoxin, was radiolabeled. Gel filtration chromatography of sera from immunotoxin treated animals demonstrated a preferential blood clearance of immunotoxin with high RTA-antibody ratio. Hepatic uptake is dependent upon Kupffer cell recognition of mannose-containing oligosaccharide structures on the RTA moiety of immunotoxin. Mannose-containing blocking agents given with immunotoxin were shown to prolong circulation time of the immunotoxin in blood including those species with higher RTA-monoclonal antibody ratios and reduce liver uptake. Effective blocking agents include ovalbumin, ovomucoid, and mannosyl-lysine (Man3Ly2). These studies demonstrate that agents specifically inhibiting hepatic uptake of immunotoxin significantly alter biodistribution and may improve their therapeutic efficacy.
Evaluation and Comparison of a Moist Granulation Technique to Conventional Methods (2000)

In the moist granulation technique (MGT), a minimum amount of liquid is used to activate a binder in a planetary mixer. Then, any excess moisture is absorbed by the addition of a moisture-absorbing substance. In the experiments described below, acetaminophen (APAP) was the model drug; polyvinylpyrrolidone (PVP) and microcrystalline cellulose (MCC) served as the binder and moisture-absorbing material, respectively. Water was used as the granulating fluid. Comparison of the MGT with direct compression (DC) and wet granulation (WG) methods was accomplished by sieve analysis (particle size) and density measurements. Moist granulation yielded an increase in particle size compared to direct compression; these results are comparable to those from the traditional wet granulation after drying and screening. Based only on the particle size, moist granulation appears comparable to conventional wet granulation for this formula. The moist granulation technique appears to have potential for the development of controlled-release formulations.
Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? (2003)

High fat intake is associated with fat mass gain through fatty acid activation of peroxisome proliferator-activated receptors delta and gamma, which promote adipogenesis. We show herein that, compared to a combination of specific agonists to both receptors or to saturated, monounsaturated, and omega-3 polyunsaturated fatty acids, arachidonic acid (C20:4, omega-6) promoted substantially the differentiation of clonal preadipocytes. This effect was blocked by cyclooxygenase inhibitors and mimicked by carbacyclin, suggesting a role for the prostacyclin receptor and activation of the cyclic AMP-dependent pathways that regulate the expression of the CCAAT enhancer binding proteins beta and delta implicated in adipogenesis. During the pregnancy-lactation period, mother mice were fed either a high-fat diet rich in linoleic acid, a precursor of arachidonic acid (LO diet), or the same isocaloric diet enriched in linoleic acid and alpha-linolenic acid (LO/LL diet). Body weight from weaning onwards, fat mass, epididymal fat pad weight, and adipocyte size at 8 weeks of age were higher with LO diet than with LO/LL diet. In contrast, prostacyclin receptor-deficient mice fed either diet were similar in this respect, indicating that the prostacyclin signaling contributes to adipose tissue development. These results raise the issue of the high content of linoleic acid of i) ingested lipids during pregnancy and lactation, and ii) formula milk and infant foods in relation to the epidemic of childhood obesity.
Sequence-Aware Factorization Machines for Temporal Predictive Analytics (2019)

In various web applications like targeted advertising and recommender systems, the available categorical features (e.g., product type) are often of great importance but sparse. As a widely adopted solution, models based on Factorization Machines (FMs) are capable of modelling high-order interactions among features for effective sparse predictive analytics. As the volume of web-scale data grows exponentially over time, sparse predictive analytics inevitably involves dynamic and sequential features. However, existing FM-based models assume no temporal orders in the data, and are unable to capture the sequential dependencies or patterns within the dynamic features, impeding the performance and adaptivity of these methods. Hence, in this paper, we propose a novel Sequence-Aware Factorization Machine (SeqFM) for temporal predictive analytics, which models feature interactions by fully investigating the effect of sequential dependencies. As static features (e.g., user gender) and dynamic features (e.g., user interacted items) express different semantics, we innovatively devise a multi-view self-attention scheme that separately models the effect of static features, dynamic features and the mutual interactions between static and dynamic features in three different views. In SeqFM, we further map the learned representations of feature interactions to the desired output with a shared residual network. To showcase the versatility and generalizability of SeqFM, we test SeqFM in three popular application scenarios for FM-based models, namely ranking, classification and regression tasks. Extensive experimental results on six large-scale datasets demonstrate the superior effectiveness and efficiency of SeqFM.
Ion beam induced damage and superlattice formation in epitaxial YBa2Cu3O7−δ thin films (1989)

We have studied the effect of ion beam irradiation on the microstructure of epitaxial YBa2Cu3O7−δ thin films. The ion beam induced defects are found to cluster in small (&lt;100 Å) disordered areas. The size and density of the disordered areas are found to increase with the ion fluence. The presence of these small disordered areas can lead to the reduction of phase coherence of the electron pair wave function. Ion beam irradiation is also found to reduce the orthorhombicity of the lattice structure. A new incommensurate superlattice phase due to ion beam induced defect ordering has also been observed.
Ultra-fast boriding for improved efficiency and reduced emissions in materials processing industries (2012)

Abstract not provided
Reduction of Iron Oxide Fine Particles from a Converter in a Powder-Particle Fluidized Bed. (1993)

微粒子とガスとの接触操作のために考案した粉粒流動層を用いて, 転炉ダスト (サブミクロン～数十μm径の酸化鉄) の直接還元を行い, 還元鉄微粒子を連続的に得た.転炉ダストの還元率に対する反応温度, 媒体粒子層高, ガス流速, 水素濃度の影響を調べた.本実験における最適運転条件では, 98%の還元率を得ることができた.また, 運転中に焼結が起こる反応条件を明らかにし, 定常な連続操作ができる範囲を確立した.得られた粉鉄は, 空気中で極めて酸化され易い.再酸化防止のための粉鉄の高温処理および低濃度酸素処理の効果を調べた.
Binding of Hydrophobic Peptides to Several Non-catalytic Sites Promotes Peptide Hydrolysis by All Active Sites of 20 S Proteasomes (2002)

The eukaryotic 20 S proteasome contains the following 6 active sites: 2 chymotrypsin-like, 2 trypsin-like, and 2 caspase-like. We previously showed that hydrophobic peptide substrates of the chymotrypsin-like sites allosterically stimulate peptide hydrolysis by the caspase-like sites and their own cleavage. More thorough analysis revealed that these peptides also stimulate peptide hydrolysis by the trypsin-like site. This general activation by hydrophobic peptides occurred even if the chymotrypsin-like sites were occupied by a covalent inhibitor and was highly cooperative, with an average Hill coefficient of 7. Therefore, this stimulation of peptide hydrolysis at all active sites occurs upon binding of hydrophobic peptides to several non-catalytic sites. The stimulation by hydrophobic peptides was not observed in the yeast Delta N alpha 3 mutant 20 S proteasomes, in 20 S-PA26 complexes, or SDS-activated proteasomes and was significantly lower in 26 S proteasomes, all of which appear to have the gated channel in the alpha-rings in an open conformation and hydrolyze peptides at much faster rates than 20 S proteasomes. Also the hydrophobic peptides altered K(m), V(max) of active sites in a similar fashion as PA26 and the Delta N alpha 3 mutation. The activation by hydrophobic peptides was decreased in K(+)-containing buffer, which favors the closed state of the channels. Therefore, hydrophobic peptides stimulate peptide hydrolysis most likely by promoting the opening of the channels in the alpha-rings. During protein breakdown, this peptide-induced channel opening may function to facilitate the release of products from the proteasome.
A new PLL method for resolvers (2010)

This paper describes a novel implementation of the classical PLL closed loop method without using VCO, DAC, counter and look-up tables. The proposed method makes use of the excitation signal of the resolver to estimate the sine/cosine of the estimated angle. The proposed method is simpler than the available techniques, and may be implemented easily using digital or basic analogue electronic circuitry. Beside simplicity of implementation, the proposed scheme offers the advantage of robustness to amplitude fluctuation of the transducer excitation signal. This paper describes the concept of the new method, simulation and experimental results.
Fludarabine phosphate: a synthetic purine antimetabolite with significant activity against lymphoid malignancies. (1991)

Fludarabine phosphate is the 2-fluoro, 5'-monophosphate derivative of vidarabine (ara-A) with the advantages of resistance to deamination by adenosine deaminase (ADA) and improved solubility. The mechanism of cytotoxic action of the compound appears to involve metabolic conversion to the active triphosphate. Fludarabine phosphate has substantial activity against lymphoid malignancies, particularly chronic lymphocytic leukemia (CLL) and low-grade non-Hodgkin's lymphoma (NHL). Its single-agent activity in CLL appears at least comparable to those of other conventional combination regimens. Its activity in Hodgkin's disease, mycosis fungoides, and macroglobulinemia, although suggestive, needs to be further defined and clinical trials are warranted in hairy cell leukemia, prolymphocytic leukemia, and previously untreated myeloma. The compound does not appear active against most common solid tumors. Early clinical trials indicated significant myelosuppression and the potential for severe neurotoxicity. Toxicity on the currently used low-dose schedules includes transient and reversible myelosuppression, nausea and vomiting, diarrhea, somnolence/fatigue, and elevations of liver enzymes and/or serum creatinine. Possible pulmonary toxicity has been suggested in several patients. The currently used low-doses of fludarabine phosphate, even with repeated administration, are well tolerated and appear safe with a negligible risk for severe neurotoxicity. Based on its single-agent activity and tolerability, the Food and Drug Administration recently granted group C designation of the drug for the treatment of patients with refractory CLL outside the clinical trials setting. The use of fludarabine phosphate in combination regimens and its impact on the natural history of the lymphoid malignancies is yet to be determined. Fludarabine phosphate may well occupy a pivotal role in the management of CLL and low-grade NHL.
Morphology and Computation (1992)

This book provides the first broad yet thorough coverage of issues in morphological theory. This book provides the first broad yet thorough coverage of issues in morphological theory. It includes a wide array of techniques and systems in computational morphology (including discussion of their limitations), and describes some unusual applications. Sproat motivates the study of computational morphology by arguing that a computational natural language system, such as a parser or a generator, must incorporate a model of morphology. He discusses a range of applications for programs with knowledge of morphology, some of which are not generally found in the literature. Sproat then provides an overview of some of the basic descriptive facts about morphology and issues in theoretical morphology and (lexical) phonology, as well as psycholinguistic evidence for human processing of morphological structure. He takes up the basic techniques that have been proposed for doing morphological processing and discusses at length various systems (such as DECOMP and KIMMO) that incorporate part or all of those techniques, pointing out the inadequacies of such systems from both a descriptive and a computational point of view. He concludes by touching on interesting peripheral areas such as the analysis of complex nominals in English, and on the main contributions of Rumelhart and McClelland's connectionism to the computational analysis of words. Bradford Books imprint
An unsupervised method for lexical acquisition based on Bootstrapping (2009)

In this paper, we present an unsupervised method called Mutual Screening Graph Algorithm based on Bootstrapping (MSGA-Bootstrapping) for lexical acquisition. Bootstrapping is a weakly supervised algorithm that has been the focus of attention in many Natural Language Processing(NLP) and Information Extraction(IE) fields, especially in learning semantic lexicons. Our approach only needs unannotated corpuses to learn new words for each semantic category. MSGA-Bootstrapping hypothesizes the semantic class of a word based on collective information over a large body of extraction pattern contexts and the extraction patterns and words can mutual reinforced. Although there are some former algorithms on this task, their precision and stability can be enhanced. By counting on the impact of both the quality information and quantity information of words and patterns when scoring the words and patterns created by them, we improve the former bootstrapping algorithm. We also make MSGA-Bootstrapping run as an unsupervised method by changing the order of its processing. Experiments have shown that MSGA can outperform previous bootstrapping algorithm Basilisk and GMR (Graph Mutual Reinforcement based Bootstrapping). And the result of using MSGA-Bootstrapping as an unsupervised method is acceptable.
KOMPSAT-5 SAR data processing: Design drivers and key performance (2011)

A general overview of KOMPSAT-5 SAR Processors chain and Software Infrastructure is provided, focusing on design drivers and key performance, mainly in terms of computation time and image quality parameters. An overview of the SAR Standard Products generated in the frame of KOMPSAT-5 mission is also depicted along with a sketch of the whole SAR Processors chain architecture. The End to End (E2E) test approach relies upon the generation of SAR Payload simulated RAW data combined with final image quality parameter estimation.
Clinical and experimental aspects of interactions between amine oxidase inhibitors and amine re-uptake inhibitors (1983)

Dangerous and even fatal interactions can occur in man following combinations of antidepressants which include non-selective MAO inhibitors. To ascertain the causation, interactions reproducing the clinical phenomena have been elicited in animals with these combinations, and the mechanisms involved have been explored by various pharmacological strategies; 5-HT re-uptake inhibitors proved especially hazardous in combination. Interactions could, however, be avoided even with the 5-HT re-uptake inhibitors, by combination with relatively selective MAO A or B inhibitors, an approach with potential clinical value.
New science and treatment paradigms for atopic dermatitis (2017)

Pediatricians are central to the successful diagnosis and management of atopic dermatitis. Increased basic and clinical research and well published clinical guidelines will lead to improved outcomes for the patients and families affected by this chronic relapsing disorder.
Modular Access to Complex Prodiginines: Total Synthesis of (+)-Roseophilin via its 2-Azafulvene Prototropisomer (2013)

Ansa-bridged prodiginines are bioactive pigments produced by bacteria. Certain of these structures are reported to be antagonists of protein-protein interactions involved in apoptosis. We describe a new entry to alkaloids of this type, demonstrated with a concise asymmetric synthesis of (+)-roseophilin (3). Our route constructs the pyrrolophane motif via phosphoryl transfer-terminated macroaldolization and passes through a previously unexplored prototropic form of the natural product.
High-Performance Flexible a-IGZO TFTs Adopting Stacked Electrodes and Transparent Polyimide-Based Nanocomposite Substrates (2011)

We demonstrated flexible amorphous In-Ga-Zn-O (a-IGZO) thin-film transistors (TFTs) on fully transparent and high-temperature polyimide-based nanocomposite substrates. The flexible nanocomposite substrates were coated on the carrier glass substrates and were debonded after the TFT microfabrication. The adoption of the Ti/IZO stacked electrodes as source/drain/ gain electrodes significantly improved the etching compatibility with other material layers, enabling successful implementation of flexible a-IGZO TFTs onto the transparent nanocomposite substrates by conventional lithographic and etching processes. The flexible a-IGZO TFTs exhibited decent mobility and mechanical bending capability. Field-effect mobility of up to 15.9 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /V · s, a subthreshold swing of 0.4 V/dec, a threshold voltage of 0.8 V, and an on/off ratio of >; 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> were extracted from the TFT characteristics. The devices could be bent down to a radius of curvature of 3 mm and yet remained normally functional. Such successful demonstration of flexible oxide TFTs on transparent flexible substrates using fully lithographic and etching processes that are compatible with existing TFT fabrication technologies shall broaden their uses in flexible displays and electronics.
A monoclonal antibody targeting amyloid β (Aβ) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and Alzheimer’s disease (2018)

Activation of the alternative complement cascade has been implicated in the pathogenesis of age related macular degeneration (AMD) and Alzheimer's disease (AD). Amyloid β (Aβ), a component of drusen, may promote complement activation by inhibiting CFI bioactivity. We determined whether Aβ reduced CFI bioactivity and whether antibodies against Aβ including a monoclonal antibody, GSK933776 could restore CFI bioactivity. We also measured CFI bioactivity in plasma of subjects with AMD and AD. In support of the GSK933776 development program in AMD (geographic atrophy), we developed a quantitative assay to measure CFI bioactivity based on its ability to cleave C3b to iC3b, and repeated it in presence or absence of Aβ and anti-Aβ antibodies. Using this assay, we measured CFI bioactivity in plasma of 194 subjects with AMD, and in samples from subjects with AD that had been treated with GSK933776 as part of the GSK933776 development program in AD. Aβ reduced the CFI bioactivity by 5-fold and pre-incubation with GSK933776 restored CFI bioactivity. In subjects with AMD, plasma CFI levels and bioactivity were not significantly different from non-AMD controls. However, we detected a positive linear trend, suggesting increasing activity with disease severity. In subjects with AD, we observed a 10% and 27% increase in overall CFI bioactivity after treatment with GSK933776 during the second and third dose. Our studies indicate that CFI enzymatic activity can be inhibited by Aβ and be altered in proinflammatory diseases such as AMD and AD, in which deposition of Aβ and activation of the alternative complement cascade are believed to play a key role in the disease process.
Determinants of Confrontation Naming Performance (1999)

Confrontation naming tests are commonly employed in neuropsychological assessment. Surprisingly little work has been done, however, to determine how various demographic, linguistic, and disease status variables influence patterns of performance on these tests. The present study examined data on the Boston Naming Test (BNT) from a total of 1,131 subjects, including 719 normals, 325 patients with Alzheimer's disease, and 87 patients with temporal lobe epilepsy. The effects of age, education, gender, and diagnostic group were examined with respect to overall scores, the influence of phonemic cuing, and performance on individual items. Profiles of scores on individual items were similar across diagnostic groups, suggesting that anomia is characterized by quantitative rather than qualitative changes in naming performance. Age and education systematically influenced scores. There was a significant effect of gender across diagnostic groups (males scoring higher than females), which appears to be due to performance on specific items. Phonemic cuing effects were similar across groups. The results are discussed with respect to the neuropsychological construct of confrontation naming and the clinical interpretation of performance on the BNT.
'Rendez-vous with the End of an Age' (1968)

The effective and successful domination of society through revolution can be seen from the state of France during the May 1968 revolt. It demonstrated the fragility of society and the means that exist with students and industrial workers to control their future and fashion the kind of society they wish to live in.
Genetic Diversity in <i>Bradyrhizobium japonicum</i> Serogroup 123 and Its Relation to Genotype-Specific Nodulation of Soybean (1987)

The genetic diversity among 20 field isolates of Bradyrhizobium japonicum serogroup 123 was examined by using restriction endonuclease digestions, one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis of total cell proteins, Southern hybridization analysis of nif and nod genes, and intrinsic antibiotic resistance profiles. All of the isolates were previously separated into three broad nodulation classes (low, medium, and high) based on their ability to form symbioses with specific soybean genotypes. Results of our studies indicate that there is a relationship between these three genotype-specific nodulation classes and groupings that have been made based on genomic DNA digestion patterns, sodium dodecyl sulfate-protein profiles, and Southern hybridizations to a nifHD gene probe. Intrinsic antibiotic resistance profiles and nodAB gene hybridizations were not useful in determining interrelationships between isolates and nodulation classes. Southern hybridizations revealed that two of the isolates had reiterated nod genes; however, there was no correlation between the presence of extra nodAB genes and the nodulation classes or symbiotic performance on permissive soybean genotypes. Hybridizations with the nif gene probe indicated that there is a relationship among serogroup, nodulation class, and the physical organization of the genome.