gebhart/patrepeval huggingface dataset:
let-7 regulates Dicer expression and constitutes a negative feedback loop (2008)

microRNAs (miRNA) are small, endogenously expressed non-coding RNAs that are sequentially processed by Drosha and Dicer from primary transcripts, by negatively regulating the expression of protein-coding genes through either translational repression or RNA degradation. Their expression patterns are developmentally regulated and/or tissue specific, while altered expressions of certain miRNAs are frequently observed in human cancers, though the underlying regulatory mechanism is largely unknown. Herein, we show that Dicer expression was inversely correlated with expression levels of mature let-7 in a panel of human cancer cell lines, showing association with cell growth and cell cycle phases. Overexpression of let-7 significantly reduced the expression of Dicer at both the protein and messenger RNA levels, whereas antisense-mediated reduction of let-7 expression conversely increased Dicer at both levels. A luciferase assay using a reporter carrying a putative target site in the 3' untranslated region of Dicer revealed that let-7 directly affects Dicer expression. Downregulation of Dicer resulted in a reduced expression of mature let-7. Furthermore, overexpression of let-7 decreased the levels of expression of other mature miRNAs, while knockdown of let-7 increased those levels. Taken together, these findings strongly suggest the possible existence of a novel regulatory loop, in which let-7 may play a role as a key miRNA for implementing the tightly regulated, equilibrated state of Dicer and various miRNAs.
Autonomic Dysfunction and Autism: Subtypes and Clinical Perspectives (2016)

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impaired social communication, restrictive interests and stereotypical repetitive behaviors. It is known that over-activation of the sympathetic branch of the autonomic nerve system (ANS) on a background of deficient parasympathetic tone is related to social, emotional and cognitive behaviors in autistic people. Different autonomic features have been linked to distinct phenotypes of autism. This review demonstrates a novel method to distinguish autism subtypes and comorbidities using autonomic indices combined with neurotransmitters and neuroimaging patterns. The clinical applications and future perspectives of autonomic indices as promising diagnostic and therapeutic biomarkers are also discussed here. [N A J Med Sci. 2016;9(4):172-180.   DOI: 10.7156/najms.2016.0904172] Key Words: autism spectrum disorder, autonomic dysregulation, heart rate variability, electrodermal activity, autistic subtype
Acoustic field characterization of the Duolith: Measurements and modeling of a clinical shock wave therapy device (2013)

Extracorporeal shock wave therapy (ESWT) uses acoustic pulses to treat certain musculoskeletal disorders. In this paper the acoustic field of a clinical portable ESWT device (Duolith SD1) was characterized. Field mapping was performed in water for two different standoffs of the electromagnetic head (15 or 30 mm) using a fiber optic probe hydrophone. Peak positive pressures at the focus ranged from 2 to 45 MPa, while peak negative pressures ranged from -2 to -11 MPa. Pulse rise times ranged from 8 to 500 ns; shock formation did not occur for any machine settings. The maximum standard deviation in peak pressure at the focus was 1.2%, indicating that the Duolith SD1 generates stable pulses. The results compare qualitatively, but not quantitatively with manufacturer specifications. Simulations were carried out for the short standoff by matching a Khokhlov-Zabolotskaya-Kuznetzov equation to the measured field at a plane near the source, and then propagating the wave outward. The results of modeling agree well with experimental data. The model was used to analyze the spatial structure of the peak pressures. Predictions from the model suggest that a true shock wave could be obtained in water if the initial pressure output of the device were doubled.
The price dynamics of common trading strategies (2000)

A deterministic trading strategy can be regarded as a signal processing element that uses external information and past prices as inputs and incorporates them into future prices. This paper uses a market maker based method of price formation to study the price dynamics induced by several commonly used financial trading strategies, showing how they amplify noise, induce structure in prices, and cause phenomena such as excess and clustered volatility.
An investigation of hydraulic-line resonance and its attenuation (1973)

An investigation of fluid resonance in high-pressure hydraulic lines has been made with two types of fluid dampers (or filters) installed in the line. One type involved the use of one or more closed-end tubes branching at right angles from a main line, and the other type was a fluid muffler installed in-line. These devices were evaluated in forced vibration tests with oscillatory disturbances over a 1000-Hz range applied to one end of the line and with oscillatory pressures measured at various stations along the main pipe. Limited applications of acoustic-wave theory to the branched systems are also included. Results show varying attenuations of pressure perturbations, depending on the number and location of branches and the type of muffler. Up to three branches were used in the branch-resonator study, and the largest frequency range with maximum attenuation was obtained for a three-branch configuration. The widest frequency ranges with significant attenuations were obtained with two types of fluid mufflers.
The Electronic Communications Privacy Act: Does the Answer to the Internet Information Privacy Problem Lie in a Fifteen Year Old Federal Statute? A Detailed Analysis, 20 J. Marshall J. Computer & Info. L. 1 (2001) (2001)

In 1986, Congress enacted the Electronic Communications Privacy Act ("ECPA") to update and clarify federal privacy protections and standards in light of changes in new technologies. Since, then, however, the Internet has grown immensely and this article discusses whether a new federal legislation is needed to meet the challenge. The author starts his analysis by defining what is "information privacy right." Then, he discusses how this right is been used and misused on the Internet. Following such definition, he discussed the ECPA Title II in detail. He analyses provisions of the ECPA, including section 2701, the definition of "access," sections 2702, 2703, 2707 and 2712. Consequently, he pointed the loopholes in these provisions such that the ECPA is not adequate to protect an individual's personal information. Hence, he proposes amendments to the ECPA, ranging from new definitions to damages provisions. He cautions readers by quoting: "technology propels us forward, and we react to the social consequences only after the fact … IT may dawn on us too late that privacy should have been saved along the way." One way to stop the erosion of individual's online privacy rights is by amending ECPA Title II to prohibit unlawful disclosure of electronic record.
Further Evidence for Endothelin as an Important Mediator of Pancreatic and Intestinal Ischemia in Severe Acute Pancreatitis (2003)

These results suggest the following: ET-1 is produced in and around the pancreas, mainly by endothelial cells, in severe acute pancreatitis; in the inflammatory setting, cytokines, activated thrombin and trypsin, may stimulate ET-1 production in a paracrine fashion; produced ET-1 may exaggerate the splanchnic microcirculation; and progressive ischemia may lead to necrosis of the pancreas and intestine.
Improvement of hepatic fibrosis by leukotriene inhibition in cholestatic rats (2009)

Chronic liver disease is characterized by inflammation and fibrosis. Angiogenesis which leading to new vasculature may have prognostic value in disease progression. This study examined the implication of 5-lipoxygenase pathway and angiogenic factors in hepatic fibrosis progression and whether, the inhibition of arachidonic acid cascade product (cysteinyl leukotrienes) can represent a potential target for therapy. Cholestasis and subsequent fibrosis was induced by common bile duct ligation and resection (BDL) for 5 weeks in rats. After surgery, Cysteinyl leukotrienes antagonist (montelukast) was orally and daily administrated (10 mg/kg) for 34 days. Sham operated and drug control groups received either saline or montelukast immediately after operation. BDL significantly increased liver hydroxyproline (Hp), nuclear factor kappa B (NF-(k )ss), transforming growth factor beta (TGF-ss), tissue inhibitor metalloproteinase (TIMP-1), vascular endothelial growth factor (VEGF), and reduced the level of matrix metalloproteinase 9 (MMP-9). On the other hand, montelukast treatment reversed all these biochemical parameters and ameliorated histopathological changes which previously induced by BDL. Findings of the present study suggest that montelukast treatment may favor collagenolytic activity through modulating hepatic expression of TGFss-, NF-(k)ss, and MMP-9/TIMP-1 ratio. Amelioration of necroinflammatory liver injury and fibrogenesis may support such assumption.
A 9-10.8 Gb/s Linear Clock and Data Recovery System with Adaptive Loop Gain (2018)

This paper presents a linear high capture range clock and data recovery (CDR) system with adaptive loop gain in 180 nm CMOS. The high capture range of the CDR is achieved by a Hogge phase detector which exploits an adjustable strobe point that varies the control voltage to get locked. The loop bandwidth of the system varies automatically for better jitter transfer without jitter peaking increasement. The proposed system operates from 9 to 10.8 Gb/s and its loop bandwidth varies from 7.5 MHz to 2.7 MHz which improves jitter transfer by 11.87 dB. The random jitter of the recovered data is <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\pmb{0.486 \ \mathbf{ps}_{\mathbf{rms}}}$</tex> at BER of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\pmb{10^{-12}}$</tex> .
Effects of oleate and insulin on the production rates and cellular mRNA concentrations of apolipoproteins in HepG2 cells. (1989)

We have reported previously that, in HepG2 cells, there is a lack of coordinate induction of triglyceride and apolipoprotein (apo) production by oleate and that insulin inhibits the production of triglyceride-rich, apoB-containing lipoproteins. The aim of the present study was to determine whether the effects of oleate and insulin on the net accumulation of apolipoproteins, specifically apoB, were related to their cellular mRNA concentrations. It was first established that the production of triglyceride-rich, apoB-containing lipoproteins and the concentration of mRNA for apolipoproteins A-I, A-II, B, and E were not affected by increasing the glucose concentration of medium from 5.5 to 20 mM. Oleate and insulin had no effect on either the accumulation in the medium or the cellular mRNA concentration of apolipoproteins A-I and A-II. On the other hand, the addition of oleate caused a two- to threefold increase in the accumulation of triglycerides in the medium without significantly affecting either the rates of accumulation or cellular mRNA levels of apolipoproteins B and E. In the presence of insulin, there was a dose-dependent decrease in the net accumulation of triglycerides and apoB and, to a lesser extent, cholesteryl esters and apoE. This inhibitory effect of insulin on the accumulation of triglycerides and apoB was partially abolished after a prolonged exposure of cells to insulin. Under these experimental conditions and at all concentrations tested, insulin had no effect on the cellular concentration of mRNA for either apoB or apoE.(ABSTRACT TRUNCATED AT 250 WORDS)
Estimation of patch array coupling model through radiated field measurements (2004)

In the design process of array antennas, coupling is one of the most important elements to be counted. The real feeding radiated coefficients can be quite different from the theoretical ones because of this effect. A compensation method is presented allowing matching of each clement of the array. The parameters of the array coupling model are obtained through the measurement of the radiation pattern of the elements without the feeding network. An application to a linear patch array is presented as an example.
Ethanolic fermentation of sucrose, sugarcane juice and molasses by Escherichia coli strain ko11 and Klebsiella oxytoca strain P2 (2005)

Escherichia coli KO11 and Klebsiella oxytoca P2 recombinants fermented sucrose to ethanol. In minimal medium with 2% or 12% added sucrose KO11 produced 75% and 41%, respectively, of the maximum theoretical yield (0.54g ethanol/g sucrose). In Luria-Bertani (LB) broth with up to 8% sucrose, KO11 presented a 94-96% yield and with 12% sucrose, KO11 presented about 69% yield (44.5g ethanol/L). P2 presented 55% of the theoretical maximum yield in minimal medium supplemented with 2% sucrose and 47% of the maximum in 12% sucrose. In LB broth with 2 or 4% sucrose, P2 presented 94-95% of the theoretical maximum yield, which fell to 73% with 8% added sucrose (31.4g ethanol/L) and 58% with 12% sucrose (37.5 g/L). Volumetric productivity in LB broth containing 2% sucrose was 0.41 g/L/h for KO11 and 1.1 g/L/h for P2, while in LB broth with 12% added sucrose, productivity was 0.96 g/L/h (KO11) and 1.4 g/L/h (P2). During fermentation of sugar cane juice by E. coli KO11 and K. oxytoca P2 produced 39.4 g/L and 42.1 g/L ethanol when supplemented with 0.5% yeast extract, micronutrients and thiamine. In sugar cane juice supplemented with LB broth ingredients, KO11 ethanol fermentation was inhibited with production of only 23.0 g ethanol/L, while P2 produced 44.2 g/L. Ethanol production by KO11 and P2, respectively, in sugarcane juice was a) 25.3 and 30.2 g/L with 0.2% ammonium sulfate, b) 24.9 and 31.6 g/L with ammonium sulfate and micronutrients, c) 25.6 and 37.5 g/L with ammonium sulfate, micronutrients and thiamine. During molasses fermentation E. coli KO11 presented low ethanol production and high lactic acid production. K. oxytoca P2 produced 25 g ethanol/L in molasses diluted 10-fold in water, with or without addition of 0.5% yeast extract, and 27.8 g/L with addition of LB broth ingredients after 96h. P2 produced 24.5, 26.9, and 28.0 g ethanol/L in molasses diluted 10-fold in vinasse, vinasse with 0.5% added yeast extract and with LB broth ingredients, respectively.
Motion-compensated frame interpolation scheme for H.263 codec (2003)

A fast block-based motion-compensated frame interpolation (FMCI) scheme was proposed in our previous work. FMCI does not require any motion search in the decoder so that the complexity is low enough to achieve frame rate increase in real time. To further improve the visual quality, we propose two add-on schemes to enhance FMCI in this research. They are the adaptive frame skip (AFS) scheme applied at the encoder and the hybrid frame interpolation (HFI) scheme which incorporates both frame repetition and FMCI at the decoder. By adopting these two add-on features, the enhanced FMCI method is made more robust to allow smooth playback.
View image generation in perspective and orthographic projection geometry based on integral imaging (2008)

A novel technique generating arbitrary view images in perspective and orthographic geometry based on integral imaging is proposed. After capturing three-dimensional object using a lens array, disparity estimation is performed for the pixels at the selected position of each elemental image. According to the estimated disparity, appropriate parts of elemental images are mapped to synthesize new view images in perspective or orthographic geometry. As a result, the proposed method is capable of generating new view images at arbitrary positions with high resolution and wide field of view.
Aplicación del método KVA en una unidad estratégica de negocio del Politécnico Colombiano Jaime Isaza Cadavid (2010)

En el presente articulo se presenta la aplicacion del modelo KVA (VALOR AGREGADO DEL CONOCIMIENTO) para la medicion del capital intelectual en las organizaciones, presentando como caso de estudio la aplicacion en una entidad de educacion superior como lo es el caso del Politecnico Colombiano Jaime Isaza Cadavid. Este articulo inicia con la presentacion del modelo KVA, seguido de la descripcion de la aplicacion del modelo y finalmente se muestran los resultados obtenidos asi como algunos elementos a tratar en trabajos futuros ABSTRACT This article presents the KNOWLEDGE VALUE AGGREGATE METHOD – KVA for the intellectual capital measure in companies, presenting specifically its application to a superior education center as it is the Politecnico Colombiano Jaime Isaza Cadavid. This paper stars with the KVA method description, followed by the application of such method in the commented institution, and finally it is presented the obtained results and some future works.
Diagnostic single strand conformational polymorphism, (SSCP): a simplified non-radioisotopic method as applied to a Tay-Sachs B1 variant (1991)

Journal Article Diagnostic single strand conformational polymorphism, (SSCP): a simplified non-radioisotopic method as applied to a Tay-Sachs B1 variant Get access P.J. Ainsworth, P.J. Ainsworth * 1Department of Pediatrics, University of Western Ontario, and Childrens Psychiatric Research InstituteLondon, Ontario3Childrens Psychiatric Research Institute600 Sanatorium Road, London, Ontario, N6H 3W7, Canada * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar L.C. Surh, L.C. Surh 2Department of Medical Genetics, Childrens Hospital of Eastern OntarioOttawa, Ontario, N6H 3W7, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar M.B. Coulter-Mackie M.B. Coulter-Mackie 1Department of Pediatrics, University of Western Ontario, and Childrens Psychiatric Research InstituteLondon, Ontario Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 2, 25 January 1991, Pages 405–406, https://doi.org/10.1093/nar/19.2.405 Published: 25 January 1991 Article history Received: 29 November 1990 Published: 25 January 1991
Biphasic Decay of Latently Infected CD4<sup>+</sup>T Cells in Acute Human Immunodeficiency Virus Type 1 Infection (2000)

Latent infection of resting CD4(+) T cells represents a major barrier to eradication of human immunodeficiency virus type 1 (HIV-1). The establishment and rate of decay of latent HIV-1 in resting CD(+) T cells from 9 acute seroconverters, 7 of whom began to receive highly active antiretroviral therapy (HAART) shortly after presentation, were studied. Before the initiation of therapy, these patients had very high frequencies of latently infected CD4(+) T cells, with a median frequency of 205 infectious units per million resting CD4(+) T cells. These values are > or =1 log higher than those seen in chronically infected patients who are not undergoing HAART. The number of latently infected cells declined dramatically after initiation of HAART but then tended to level off at a low but stable level. The biphasic decay of latent HIV in resting CD4(+) T cells in acute seroconverters supports current models of pre- and postintegration latency.
How to leak on key updates (2011)

In the continual memory leakage model, security against attackers who can repeatedly obtain leakage is achieved by periodically updating the secret key. This is an appealing model which captures a wide class of side-channel attacks, but all previous constructions in this model provide only a very minimal amount of leakage tolerance during secret key updates. Since key updates may happen frequently, improving security guarantees against attackers who obtain leakage during these updates is an important problem. In this work, we present the first cryptographic primitives which are secure against a super-logarithmic amount of leakage during secret key updates. We present signature and public key encryption schemes in the standard model which can tolerate a constant fraction of the secret key to be leaked between updates as well as a constant fraction of the secret key and update randomness to be leaked during updates. Our signature scheme also allows us to leak a constant fraction of the entire secret state during signing. Before this work, it was unknown how to tolerate super-logarithmic leakage during updates even in the random oracle model. We rely on subgroup decision assumptions in composite order bilinear groups.
FAME: Face Authentication for Mobile Encounter (2013)

The use of mobile devices is continuously growing, together with their ability to store and exchange sensitive data. This has spurred the interest, from one side, in exploiting their apparent vulnerabilities, and on the other side, in protecting users from any malfeasance. In this scenario, it has become essential to develop and deploy secure access and identification protocols on mobile platforms. Another emerging aspect that also needs attention bears on the commercial and social use of identity management systems. Towards such ends, this paper proposes using biometrics as the technology of choice, and describes FAME (Face Authentication for Mobile Encounters). FAME is an embedded application for mobile devices that provides both verification and identification, including identity management to support social activities, e.g., finding doubles in a social network. Such functionalities are implemented subject to privacy and security concerns. FAME cascade architecture is modular. The single modules perform image acquisition, anti-spoofing, face detection, face segmentation, feature extraction, and face matching. FAME also provides continuous recognition and best biometric sample selection, that both accommodate varying pose and illumination. All procedures are optimized for mobile use, using low-demanding and computation-light algorithms. Preliminary questionnaires administered to users engaged with using FAME show user acceptance, ease of use, and reliability.
Fiber-optic transducer for blood pressure measurements (1988)

A novel type of fiber-optic pressure transducer has been developed and tested for biomedical application. It consists of two parts: a pressure-sensing membrane and a fiber-optic displacement transducer which is based on the light intensity loss caused by angular misalignment between two fibers. The light intensity change is registered by a photodiode. The pressure transducer is registered by a photodiode. The pressure transducer has been evaluated for static and dynamic pressure measurements. Not only does it have adequate linearity and frequency response, safety, and small size, but also it may be an attractive device for developing multiple-site pressure-detecting catheters.< <ETX>></ETX>
Irradiation-Grafted Polymeric Films. III. Development of Improved Anion-Selective Membranes for Desalting Water (1971)

Abstract Experimental anion-selective membranes have been prepared and evaluated as electrodialysis membranes. The membranes were prepared by grafting tertiary amines onto polyethylene films. After grafting, the membranes were made ionic in character by conversion to the corresponding hydrochloride or by quaternizing with 1-bromobutane. Evaluation demonstrated the feasibility of preparing membranes having acceptable transport numbers, dialysis coefficients, and electrical resistances for use in electrodialysis processes.