gebhart/patrepeval huggingface dataset:
A novel manganese starvation-inducible expression system for<i>Lactobacillus plantarum</i> (2013)

A novel expression system for Lactobacillus plantarum was developed. This system is based on the manganese starvation-inducible promoter from specific manganese transporter of L. plantarum NC8, which was cloned for the first time. The expression of a β-glucosidase from Pyrococcus furiosus (CelB) was achieved by cultivating L. plantarum NC8 at low manganese concentrations with MRS medium and the pmntH2-CelB expression vector. A CelB activity of 8.52 μkatoNPGal L(-1) was produced in a bioreactor (4 L). The advantages of the novel expression system are that no addition of an external inducing agent was required, and additionally, no further introduction of regulatory genes was necessary. The new promoter meets the general demands of a food-grade expression system.
Chrysin and Luteolin Attenuate Diabetes‐Induced Impairment in Endothelial‐Dependent Relaxation: Effect on Lipid Profile, AGEs and NO Generation (2013)

Chrysin and luteolin are two important plant flavonoids. In the present study, we hypothesized that they protect against deleterious vascular effects of diabetes. Diabetes was induced in rats by streptozotocin (STZ) injection, while chrysin and luteolin were administered two weeks after STZ administration for 6 weeks. Then, blood pressure (BP) and serum levels of glucose, advanced glycation end products (AGEs), triglycerides (TGs), total cholesterol and low density lipoprotein-cholesterol (LDL-C) were determined. Concentration response curves for KCl, phenylephrine (PE), acetylcholine (ACh) and ACh-induced NO generation were obtained in isolated aorta. Compared with control, diabetes increased diastolic and systolic BP, while chrysin and luteolin attenuated diastolic BP elevation without affecting the developed hyperglycemia. Diabetes increased contractile response of aorta to KCl, PE, decreased relaxation response to ACh, while chrysin and luteolin prevented the impaired response to ACh. In addition, diabetes was accompanied by elevated levels of TGs, total and LDL cholesterol, while both chrysin and luteolin prevented this dyslipidemia. Furthermore, chrysin decreased the elevated AGEs level in serum of diabetic animals, while luteolin abrogated the impaired NO generation in diabetic aorta. Collectively, chrysin and luteolin attenuate diabetes-evoked impairment in endothelial-dependent relaxation possibly via ameliorating detrimental changes in lipid profile, AGEs and NO generation.
An annexin 1 (ANXA1)‐derived peptide inhibits prototype antigen‐driven human T cell Th1 and Th2 responses <i>in vitro</i> (2001)

In prototype Th1 and Th2-type human T cell responses, ANXA1-derived peptides can inhibit antigen-driven cellular proliferation and cytokine production.
Sorption properties of the iminodiacetate ion exchange resin, amberlite IRC‐718, toward divalent metal ions (2007)

Abstract The sorption properties of the commercially available cationic exchange resin, Amberlite IRC‐718, that has the iminodiacetic acid functionality, toward the divalent metal‐ions, Fe 2+ , Cu 2+ , Zn 2+ , and Ni 2+ were investigated by a batch equilibration technique at 25°C as a function of contact time, metal ion concentration, mass of resin used, and pH. Results of the study revealed that the resin exhibited higher capacities and a more pronounced adsorption toward Fe 2+ and that the metal‐ion uptake follows the order: Fe 2+ > Cu 2+ > Zn 2+ >Ni 2+ . The adsorption and binding capacity of the resin toward the various metal ions investigated are discussed. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
In-Vehicle History Recording of Diesel Engine Performance Parameters (1981)

<div class="htmlview paragraph">Recently developed portable instrumentation has now made feasible and practical the accurate history recording of diesel engine fuel consumption for load factor data along with engine speed and other performance parameters during actual vehicle operation. Engine load factor data is determined by the instantaneous fuel consumption as a percentage of full load fuel consumption and is important in the design and the application of engine components and accessories. The required instrumentation consists of a precision fuel metering system, an electronic tachometer, temperature transducers, and compact integrated circuit histogram data recorders.</div>
[Hyperbaric Bupivacaine 1% (Marcaine, Carbostesine heavy) for hemi-spinal anaesthesia in orthopedic (author's transl)]. (1975)

A report is given on 170 orthopedic operations performed under hemi-spinal anaesthesia. The anaesthetic agent used was hyperbaric bupivacaine 1% (Marcaine, Carbostesine). Of these cases 92 were total hip joint replacements and 78 other operations of the lower extremities. Generally, the patients were classified as category three risks (A.S.A.) Their average age was 63 years. The anaesthetics and postoperative courses were smooth. In the total prosthetic hip joint operations hypotension during the implantation of acelabulum--or femur--cement was not observed. With doses of 1 ml of the local anaesthetic the average duration of analgesia was 3 hours and 10 minutes, and with added vasoconstrictor 4 hours.
Dielectric Properties of Some Alkylsilanes (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDielectric Properties of Some AlkylsilanesAubrey P. Altshuller and Louis RosenblumCite this: J. Am. Chem. Soc. 1955, 77, 2, 272–274Publication Date (Print):January 1, 1955Publication History Published online1 May 2002Published inissue 1 January 1955https://pubs.acs.org/doi/10.1021/ja01607a007https://doi.org/10.1021/ja01607a007research-articleACS PublicationsRequest reuse permissionsArticle Views208Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recursive attitude determination from vector observations Euler angle estimation (1987)

This work presents an algorithm that processes a sequence of pairs of measured vectors to obtain a minimum variance estimate of the Euler angles which describe the attitude between two coordinate systems. The measurement equation is nonlinear and, unlike the direction cosine matrix and the quaternion estimation problems, the dynamics of the estimated angles are nonlinear as well. The algorithm can also handle singular cases, thus extending the use of Euler angles to all-attitude vehicles. Results of Monte-Carlo simulations are presented that demonstrate the efficiency of the algorithm. This work is a natural extension of the algorithms that were recently developed for estimating the direction cosine matrix and the quaternion, therefore it completes the set of recursive minimum variance algorithms for estimating the three common forms of expressing attitude.
Identification and Validation of Evolutionarily Conserved Unusually Short Pre-mRNA Introns in the Human Genome (2015)

According to the length distribution of human introns, there is a large population of short introns with a threshold of 65 nucleotides (nt) and a peak at 85 nt. Using human genome and transcriptome databases, we investigated the introns shorter than 66 nt, termed ultra-short introns, the identities of which are scarcely known. Here, we provide for the first time a list of bona fide human ultra-short introns, which have never been characterized elsewhere. By conducting BLAST searches of the databases, we screened 22 introns (37-65 nt) with conserved lengths and sequences among closely related species. We then provide experimental and bioinformatic evidence for the splicing of 15 introns, of which 12 introns were remarkably G-rich and 9 introns contained completely inefficient splice sites and/or branch sites. These unorthodox characteristics of ultra-short introns suggest that there are unknown splicing mechanisms that differ from the well-established mechanism.
Evaluation of Mechanical Properties of Functionally Graded Materials (1998)

Abstract An experimental technique for evaluating the elastic properties of functionally graded materials (FGMs) is proposed. Ultrasonic pulse-echo measurements in conjunction with elastic impact testing permit determination of Young's modulus, Poisson's ratio, and the mass density of the material and its longitudinal variation. The details of the formulation of the technique and the implementation issues are discussed in this paper. These techniques have been applied successfully to evaluate the properties of a model functionally graded material.
<i>N</i>-Chloroacyl-6-<i>O</i>-triphenylmethylchitosans:  Useful Intermediates for Synthetic Modifications of Chitosan (2005)

An efficient synthetic route was developed for the mild chloroacylation of chitosan with different chloroacyl chlorides. Full N-chloroacylation was obtained with this procedure without any O-acylation, and products having lower degrees of substitution can also be produced. Organo-soluble 6-O-triphenylmethylchitosan was used as a starting material for the acylation reactions. The resulting N-chloroacyl-6-O-triphenylmethylchitosan intermediates were also organo-soluble and characterized by FT-IR. N-Methylpiperazine moieties were attached to make end products that were sufficiently soluble for characterization by NMR and also to prove that the present intermediates could be used for further modifications. The end products were fully characterized by 1H NMR, 13C NMR, and 2D 1H-13C heteronuclear single-quantum correlation NMR spectroscopy. The degrees of substitution were determined by 1H NMR. Molecular weight determination by GPC-LS displayed a significant degradation of the polymer. The weight-average molar masses (M(w)) of the end products ranged from 29.6 to 49.4 kDa, when the M(w) of the starting material was 144.2 kDa.
Clinical applications and value of receptor levels in treatment of prostate cancer (1984)

Factors affecting the validity and interpretation of androgen receptor (AR) assays on prostatic carcinoma tissue are discussed, and attempts to relate AR concentration with response of the patient to hormonal manipulation are reviewed. It is concluded that nuclear AR content may be useful in evaluating prognosis and likely response to hormonal therapy, and that, owing to the heterogeneity of many prostatic carcinoma specimens, a reliable histochemical method for the assessment of androgen sensitivity would be a valuable supplement to the biochemical assay.
Efficient Synthesis of Linear Reversible Circuits (2003)

In this paper we consider circuit synthesis for n-wire linear reversible circuits using the C-NOT gate library. These circuits are an important class of reversible circuits with applications to quantum computation. Previous algorithms, based on Gaussian elimination and LU-decomposition, yield circuits with O(n^2) gates in the worst-case. However, an information theoretic bound suggests that it may be possible to reduce this to as few as O(n^2/log n) gates. We present an algorithm that is optimal up to a multiplicative constant, as well as Theta(log n) times faster than previous methods. While our results are primarily asymptotic, simulation results show that even for relatively small n our algorithm is faster and yields more efficient circuits than the standard method. Generically our algorithm can be interpreted as a matrix decomposition algorithm, yielding an asymptotically efficient decomposition of a binary matrix into a product of elementary matrices.
Neurosteroid Analogues. 4. The Effect of Methyl Substitution at the C-5 and C-10 Positions of Neurosteroids on Electrophysiological Activity at GABA<sub>A</sub> Receptors (1996)

A series of analogues of the neuroactive steroids 3 alpha-hydroxy-5 alpha-pregnan-20-one and 3 alpha-hydroxy-5 beta-pregnan-20-one were studied to elucidate the mode of binding of 5 alpha-and 5 beta-reduced steroids to steroid binding sites on GABAA receptors. Analogues which were either 3 alpha-hydroxy-20-ketosteroids or 3 alpha-hydroxysteroid-17 beta-carbonitriles and which contained various methyl group substitution patterns at C-5 and C-10 were prepared. Evaluations utilized whole-cell patch clamp electrophysiological methods carried out on cultured rat hippocampal neurons, and the results obtained with the rigid 17 beta-carbonitrile analogs were analyzed using molecular modeling methods. The molecular modeling results provide a rationale for the observation that the configuration of the hydroxyl group at C-3 is a greater determinant of anesthetic potency than the configuration of the A,B ring fusion at C-5. The electrophysiological results identify steric restrictions for the space that can be occupied in 5 alpha- and 5 beta-reduced steroid modulators of GABAA receptors in the regions of space proximate to the steroid C-5, C-10, and possibly C-4 positions. This information is useful for the development of nonsteroidal analogues that can modulate GABAA receptors via interactions at steroid binding sites.
Measurement of 200 Gbit/s optical eye diagram byoptical sampling with gain-switched optical pulse (2000)

A 200 Gbit/s optical eye diagram, which was generated by compressing and four-multiplexing a 10 Gbit/s optical signal, has been clearly observed by using an optical sampling system. The time resolution was 1.25 ps and the timing jitter was 160 fs with a timing-jitter reduced gain-switched optical pulse, and the 3 dB bandwidth of the optical frequency was 310 GHz.
Dynamic MRI of the TMJ under physical load (2013)

The feasibility of the golden ratio-based radial MRI technique to dynamically capture the anatomy of the TMJ under physical load was demonstrated in this initial study.
Biosorption of palladium and platinum by sulfate‐reducing bacteria (2003)

Abstract The biosorption capacities of palladium and platinum were studied in three different species of Desulfovibrio: Desulfovibrio desulfuricans, Desulfovibrio fructosivorans and Desulfovibrio vulgaris . The influence of several parameters such as pH, acidic background and competitor anions on biosorption equilibria and biosorption kinetics were evaluated. Differences were observed between the three strains of Desulfovibrio with respect to the optimum biosorption parameters of both metals, suggesting differences in the metal speciation–dependent sorption mechanisms involved. The most promising Pd and Pt biosorption results were obtained using D desulfuricans with rapid achievement of equilibrium (90% of total sorption was achieved in 5–15 min) and a maximum value of 190 mg g −1 dry biomass and 90 mg g −1 dry biomass for Pd and Pt accumulation respectively, at pH 3. Copyright © 2003 Society of Chemical Industry
Evidence of a Reduced Sialic Acid Content in Serum Transferrin in Male Alcoholics (1981)

A qualitative change of the microheterogeneity of serum transferrin, demonstrated by isoelectric focusing, has previously been found to occur frequently and with high specificity in alcoholic patients during current abuse, and has been proposed as a new marker of alcoholism. Certain indirect evidence has supported the assumption that the basis for the altered transferrin heterogeneity would be a reduced sialic acid content. In this investigation serum transferrin from healthy controls and alcoholic patients was purified by affinity chromatography on antitransferrin Sepharose 4B. The sialic acid content in transferrin was thereafter determined directly. Transferrin from alcoholic patients showed a 22% lower sialic acid concentration than control transferrin, which was highly significant. These data together with results from experiments with neuraminidase and galactose-binding lectin provide evidence that in alcoholism at least two sialic acid residues are missing in a significant fraction of serum transferrin. This observation may indicate that sialic acid residues are missing in a significant fraction of serum transferrin. This observation may indicate that sialic acid metabolism is one important target of the biological action of ethanol.
Über die Dehydratisierung von Alkoholen mittels Phthalsäureanhydrids (1. Mitteil.) (1950)

Abstract Siedendes Phthalsäureanhydrid bei Gegenwart von Benzolsulfonsäure dehydratisiert Alkohole leicht zu Alkenen.
Pharmacokinetics, Pharmacodynamics, and Safety of a Lipid-Lowering Adenosine A1 Agonist, RPR749, in Healthy Subjects (2004)

RPR749 and its methylated metabolite are orally active and selective adenosine A(1) agonists that can inhibit lipolysis and lower plasma triglyceride levels in a variety of animal models. RPR749 also appears to lower free fatty acid (FFA) and insulin levels and may have additional lipid-modifying effects. This double-blind, single increasing-dose, placebo-controlled, parallel group, randomized study, the first done in humans, evaluated the safety, pharmacokinetics, and pharmacodynamics (effect on FFA) after a single oral dose of up to 200 mg RPR749 or placebo. Six parallel groups of 8 healthy men (6 active and 2 placebo/group) were enrolled in the study. Plasma samples were collected for up to 72 hours post-dose. RPR749 and its metabolite RPR772 concentrations were measured by a validated LC/MS/MS method with a minimal quantifiable limit of 1 ng/mL. RPR749 was safe and well tolerated as a single oral dose up to 200 mg. The mean plasma concentrations of RPR749 were approximately 30-fold higher than the mean RPR772 plasma concentrations. The mean terminal half-life (t(1/2)) of RPR749 and RPR772 were similar (approximately 16.4 hours). Mean values for serum insulin, triglycerides, glycerol, and blood glucose remained within normal ranges. Mean FFA concentrations in serum decreased in all treatment groups with the maximal decrease in the 200-mg dose group. In conclusion, RPR749 has the ability to reduce circulating levels of FFA that can be related to plasma RPR749 concentrations and thus possesses pharmacological properties that may be beneficial in treating coronary artery diseases and hyperlipidemia.
A Novel Phase Matching Technique for A Poled Polymer Waveguide (1994)

Abstract An electric field induced dynamic phase-matching which can improve the thickness tolerance of waveguide SHG device is first demonstrated using organic nonlinear optical (NLO) materials with low glass transition temperature (Tg). The advantage of this technique is the possibility to control an effective refractive index of NLO waveguide at room temperature. As a result of refractive index variation induced by an external electric field, the effective phase-matching dimension can be controlled from 1.272 μm to 1.260 μm. The phase-matching condition i.e. conversion efficiency of second harmonic light can be easily tuned by changing a poling electric field. The obtained net conversion efficiency of low Tg NLO slab waveguide was found to be 1.5 °. No decay of conversion efficiency for low Tg NLO waveguide is observed in the presence of an electric field.
Synthesis and reactivity of a C3-symmetric trinuclear zinc(ii) hydroxide catalyst efficient at phosphate diester transesterification (2007)

Inspired by trinuclear Zn(II) sites in enzymatic systems, a ligand system containing three preorganized (2-pyridyl)methyl piperazine moieties anchored onto a rigid C3-symmetric triphenoxymethane platform has been developed for preorganizing three zinc ions into an environment conducive to intramolecular interaction. Zinc(II) binding by this ligand has been analyzed by means of potentiometric measurements in 50% (v/v) CH3CN-H2O solutions. Subsequently a C3-symmetric trinuclear Zn(II) hydroxide complex of the C3-symmetric ligand was synthesized and fully characterized using NMR spectroscopy and X-ray crystallography. This complex induces a 16,900-fold rate enhancement in the catalytic cyclization of the RNA model substrate, 2-hydroxypropyl-p-nitrophenyl phosphate (HPNP, pH 6.7, 25 degrees C) over the uncatalyzed reaction with multiple catalyst turnovers. The observed differences in the pH-rate profile can be attributed to the varying concentration of various trinuclear zinc species. The trinuclear Zn(II) catalyst exhibits a higher hydrolytic activity compared to its mononuclear analogue. The reactivity and structural features of this trinuclear Zn(II) complex will be discussed.
Methane Sulphonic Acid is Green Catalyst in Organic Synthesis (2015)

Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry. It publishes standard research papers in almost all thrust areas of current chemistry of academic and commercial importance. It provides a platform for rapid publication of quality research papers, reviews and chemistry letters. Oriental Journal of Chemistry is abstracted and indexed in almost all reputed National and International agencies.
Polyamine biosynthesis in rat prostate. Substrate and inhibitor properties of 7-deaza analogs of decarboxylated S-adenosylmethionine and 5'-methylthioadenosine (1977)

The 7-deaza analogue of 5'-methylthioadenosine, a nucleoside end product in polyamine biosynthesis, has been synthesized. This analogue has been shown to competitively inhibit the hydrolytic cleavage of the purine-ribose bond in methylthioadenosine with Ki congruent to Km. In addition, the 7-deaza analogue of decarboxylated S-adenosylmethionine, a cofactor in the biosynthesis of both spermidine and spermine, has been synthesized. This analogue has been shown to act as a substrate in the reaction catalyzed by spermidine synthase, in which severe substrate inhibition by both the normal nucleoside substrate and the 7-deaza analogue is observed. These results are discussed in terms of possible end product regulation of polyamine biosynthesis and the possible substitution of the nucleoside antibiotic, tubercidin, for adenosine in reactions involving S-adenosylmethionine and its metabolites.
Content Based Microblogger Recommendation (2012)

Micro logs are social networking systems, where users frequently contribute very short (micro) posts. Micro loggers follow others' posts via subscription. However, it is a challenge to determine micro loggers worthy of following, since their contributions are fragmented amidst numerous and various tiny posts. Furthermore, micro posts typically include abbreviations, mispeled words, special tokens, and are not grammatically correct. Consequently, typical NLP techniques are often not very useful in determining what a user posts about. This work proposes a content-based, as opposed to friendship-based, micro blogger recommendation model, where given an user query a ranked list of microbloggers is produced. This paper presents the recommendation model, a prototype implementation, an user evaluation.