gebhart/patrepeval huggingface dataset:
[Dynamic telethermography in dermatology]. (1975)

Dynamic telethermography permits direct observation of the emission of infrared rays from the skin of the human body. A certain number of dermatological diseases are liable to modify this emission and then show more or less localised hypo- or hyperthermia, e. g. malignant melanomas which represent the best indication for this new means of paraclinical investigation which has the advantage of being strictly atraumatic. The other black tumours of the skin, the skin carcinomas, certain hematodermias, cutaneous metastases and pre-cancerous conditions, radiotherapy lesions and burns, and hemangiomas may also benefit from this method. In fact, the latter may give some information on their degree of spread and their extension and response to treatment.
UCB SA (2006)

Pharmaceutical strategic business consultancy involved in partnering, licensing, acquisitions, divestments and new business start-ups. We assist in due diligence and write expert reports for investors. We are experts in business intelligence and markets
Novel plant-derived tumor inhibitors and their mechanisms of action. (1976)

The activity-directed isolation of new tumor inhibitors of plant origin has yielded many novel compounds with significant growth-inhibitory properties. A large proportion of the new compounds contain highly electrophilic functionalities and chemical and biochemical studies are yielding a growing body of evidence to support the view that these compounds may act by selective alkylation of growth-regulatory biologic macromolecules. The selectivity may result from many factors, among which are transport of the tumor inhibitor into the cell and the chemical nature and steric environment of the specific nucleophile to be alkylated. Model studies support the hypothesis that the inhibition of tumor growth by the new agents may be attributable to selective alkylation of key enzymes which control cell division.
Correlations between the Polarization and Strain Induced by Electric field in $\textrm{0.9Pb}\textrm({Mg}_{1/3}\textrm{Nb}_{2/3})\textrm{O}_3$-$\textrm{0.1PbTiO}_3$ Relaxor Ferroelectrics (1999)

Polarization and strain induced by unipolar electric field (P\ulcorner, S\ulcorner), those induced by bipolar electric field (P, S) and remanent polarization (P\ulcorner) were investigated in 0.9Pb(Mg\ulcornerNb\ulcorner)O-relaxor ferroelectric ceramics in the temperature range of ~. From the temperature dependence of polarization and strain, the transition from predominantly paraelectric (electrostrictive) to partially ferroelectric (piezoelectric) is visualized. Under the given temperature, the P\ulcorner/P\ulcorner is always larger than the S\ulcorner/S\ulcorner and the difference between them becomes larger ass the temperature decrease. The S\ulcorner/P\ulcorner increases as the temperature decreased below phase transition temperature. It was suggested that these experimental results might be explained with a simple rigid ion model concentrating on BO\ulcorner octahedron.
Mechanism of Addition Agent Reaction in Bright and Leveling Nickel Deposition (1961)

Organic addition agents synthesized with C‐14 as well as S‐35 have been used in a continuing study of the leveling phenomenon associated with the deposition of bright nickel. Analysis of deposits and the gaseous products of de position have given information concerning the breakdown of addition agents and have led to a model which may account for the synergistic effect on leveling brought about by combinations of addition agents.
Adiabatic coupling in tapered air-silica microstructured optical fiber (2001)

We study adiabatic mode propagation in tapered air-silica microstructured optical fibers and demonstrate efficient coupling into a robust high-delta microstructured fiber. In the waist region of the taper, the core mode is tightly confined by the air holes and exhibits properties similar to a high-delta waveguide such as enhanced peak intensity and widely flattened anomalous dispersion. We exploit these properties to generate tunable self-frequency shifting Raman solitons over the communications window from 1.3 μm to 1.65 μm, with over 60% conversion efficiency These fiber devices are practical for several reasons: they can be fusion spliced to standard single-mode fibers with relatively low loss, they are mechanically strong, due to the supporting cladding, and because the mode is isolated from the surrounding air interface, they can potentially be recoated allowing for packaging.
Deposition of an organic–inorganic hybrid material onto carbon fibers via the introduction of furfuryl alcohol into the atomic layer deposition process of titania and subsequent pyrolysis (2016)

Exposing bundles of carbon and quartz fibers as well as silicon wafers to sequential pulses of gaseous TiCl4/furfuryl alcohol (FFA) and H2O/TiCl4/furfuryl alcohol, respectively gave rise to conformal organic/inorganic coatings on all of these substrates. The deposition during the FFA pulse is self-limiting and the process shows a linear growth per cycle of (0.65 ± 0.05) nm/cycle in the absence of water pulses and (1.68 ± 0.04) nm/cycle in the presence of water pulses. A possible reaction mechanism comprises classic atomic layer deposition steps as well as a polymerization route of furfuryl alcohol, which leads to the release of water during the furfuryl alcohol pulse and further comprises hydrolytic ring opening of furan rings and/or hydrolytic cleavage of Ti–Cl bonds. Since an additional subsequent water pulse significantly enhances the growth, it seems that without additional water pulse these reactions are limited by the amount of water that is formed or desorbed. Oxidizing the coated carbon fibers at 700 °C gave rise to thin-walled titania microtubes with wrinkled tube walls. Titania/carbon-hybrid microtubes were obtained by coating quartz fibers with TiO2/FFA, pyrolysis at 600 °C under nitrogen atmosphere, and subsequent etching with hydrogen fluoride. Energy dispersive x-ray spectroscopy and x-ray photoelectron spectroscopy (of coated silicon wafers) confirm that the coating consists predominantly of titanium, oxygen, carbon, and comprises residual chlorine. The stoichiometry is TiO2C3.5Cl0.1 before and TiO1.8C1.4 after the pyrolysis. According to XPS and thermogravimetric analysis, the molar ratio of titania to furfuryl alcohol is approximately 1.
PDR: physicians' desk reference (1989)

Physicians' Desk Reference has been the authoritative source on prescription drugs for 70 years. Found in virtually every physician's office, pharmacy, clinic, and library, no medical reference is more current, more recognized, or more respected. Now in its 70th edition, PDR contains full, FDA-approved drug label information, including warnings and precautions, drug interactions, and hundreds of full-color pill images. Every label in PDR includes information on dosages, side effects, and safety information, such as contraindications, pregnancy ratings, and interactions with other drugs, food, and alcohol. Data on clinical trials are also included.
3-D model-data correspondence and nonrigid deformation (2002)

Modeling nonrigid moving 3-D objects entails recovery of global motion, global shape, and local shape. The already difficult problem of tracking nonrigid local shape is made worse by the need for a model-data correspondence scheme to make tracking possible. Both problems are addressed. Various methods for establishing 3-D model-data correspondence are discussed, and a correspondence scheme for tessellated data is presented. A force-based method for nonrigid motion tracking is presented. The authors' method does not use complex finite element techniques but follows a residual force-based dynamic model for local deformation. Another novel feature is that the net forces are obtained by an adaptive force distribution scheme which ensures smooth and stable deformation. Results are presented of tracking simulated as well as real 3-D data of the inner wall of the heart ventricle from segmented magnetic resonance images.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Peptide Sequence of Heparin/Heparan Sulfate (HP/HS)-interacting Protein Supports Selective, High Affinity Binding of HP/HS and Cell Attachment (1998)

We previously have identified a novel cell surface heparan sulfate/heparin (HS/HP)-interacting protein (HIP) found in human uterine epithelia and a variety of other human epithelial and endothelial cells and cell lines (Liu, S., Smith, S. E., Julian, J., Rohde, L. H., Karin, N. J., and Carson, D. D. (1996) J. Biol. Chem. 271, 11817-11823; Rohde, L. H., Julian, J., Babaknia, A., and Carson, D. D. (1996) J. Biol. Chem. 271, 11824-11830). The amino acid sequence predicted for HIP revealed a potential HS/HP-binding motif. In the present studies, a synthetic peptide corresponding to this putative HS/HP-binding motif, HIP peptide, was synthesized and examined with regard to its HS/HP binding and cell attachment promoting activity. Results using solid phase binding assays demonstrate that HIP peptide binds HS/HP with high selectivity and has high affinity for bulk HP (50% saturation congruent with 300 nM) and even higher affinity for a subset of polysaccharides found in commercial [3H]HP (half-saturation congruent with 10 nM). Moreover, HIP peptide binds subsets of cell and extracellular matrix-associated HS and dermatan sulfate expressed by RL95 cells, a human uterine adenocarcinoma cell line. HIP peptide also binds a similar fraction of HS as well as dermatan sulfate expressed by JAR cells, a human choriocarcinoma cell line. In contrast to binding of cell- or extracellular matrix-associated HS, HIP peptide does not bind secreted or released forms of HS or DS from either RL95 or JAR cells to a significant extent. HS species that bind to HIP peptide are generally larger, have a higher negative charge density, and have a larger proportion of di- and trisulfated disaccharide units than HS species that do not bind to HIP peptide, demonstrating structural differences among these polysaccharides. This same peptide supports HS-dependent JAR cell attachment. Collectively, these data demonstrate that a linear peptide sequence found within HIP can account, at least in part, for the HS/HP binding and cell adhesion promoting activities of this protein.
Replication of Animal Viruses in Differentiating Muscle Cells: Influenza Virus A (1977)

Cells were cultured from the breast muscle of 11- to 12-day-old chick embryos and were grown under conditions optimal for the development of the cells into terminally differentiated, fused myotubes. Myotubes were infected with influenza virus A/Ann Arbor/6/60(H2N2) at high multiplicity, and synthesis of virus-specific proteins and RNAs was detected by haemadsorption, fluorescence microscopy and/or isotope labelling and electrophoresis techniques. Provided that myotubes were maintained at temperatures below 39 degrees C after infection, production of virus components and yield of infectious virus in these cells was similar to those observed in infected chick kidney cells. However, if cells were maintained at temperatures of 39 degrees to 40 degrees C after infection, virus nucleoprotein was prominent in the nuclei, and synthesis of virus-specific polypeptides and of plus-strand RNA was reduced about fourfold to 20-fold compared to that detected at lower temperatures. Moreover, infectious virus was not produced when temperatures of 39 to 40 degrees C were used during virus replication. The results demonstrate that under suitable conditions avian myotubes formed in culture resemble epithelioid cells in their ability to support the productive replication of influenza virus.
Pipelined Sampled-Delay Focusing in Ultrasound Imaging Systems (1987)

A sampled-delay focusing technique was recently proposed by the authors which completely eliminates the use of analog L-C delay lines for beam focusing in completely eliminates the use of analog L-C delay lines for beam focusing in ultrasound B-mode imaging systems. With this approach, the product of sampling rate and maximum time delay is required to be less than unity. To remove this constraint, we propose in this paper a first-in-first-out pipelining technique. This allows one to perform beam steering and dynamic focusing simultaneously on a resolution-cell basis and in a completely digital fashion without the use of analog L-C delay lines.
Characterisation of CuInS<sub>2</sub>/ Zn(Se,O)/ZnO solar cells as a function of Zn(Se,O) buffer deposition kinetics in a chemical bath (2002)

Abstract Thin‐film solar cells of CuInS 2 /Zn(Se,O)/ZnO configuration have been studied from the point of view of their dependence on the Zn(Se,O) chemical bath deposition (CBD) conditions. The kinetics of deposition of the Zn(Se,O) buffer is followed during cell processing with a quartz crystal microbalance (QCM). Two different CBD growth mechanisms yield buffer layers with different properties. Under a predominant electroless deposition reaction, the resulting buffer layer has mixed ZnSe–ZnO composition. The solar cells with this buffer type show higher fill factor (FF) and lower open‐circuit voltage (V oc ). Under a chemical growth regime, the buffer layer has higher ZnSe proportion, giving rise to cells with higher V OC , but lower FF and stability. The parameters of this second type of cell also show major dependence on illumination effects (light‐soaking effects). Electron‐beam‐induced current (EBIC) and cathodoluminescence (CL) measurements are carried out to characterise the CuInS 2 /Zn(Se,O) junctions formed under the two buffer growth regimes. Cross‐sectional EBIC shows a wider space charge region (SCR) than expected for p‐CuInS 2 in contact with Zn(Se,O), and the p–n junction is driven within the CuInS 2 phase. These results reflect a chemical modification of CuInS 2 , most probably caused by the ammonia of the bath solution. CL shows more defective interfaces when Zn(Se,O) is deposited under the chemical mechanism (slower deposition rate, hence longer contact time of the CuInS 2 with the bath solution) than under the electroless kinetics (faster deposition rate). Copyright © 2002 John Wiley & Sons, Ltd.
Purification and Characterization of <i>Par·</i> I, Major Allergen of Parietaria officinalis Pollen (1991)

Par o I, a major allergen of Parietaria officinalis, was purified from the pollen extract. The purified allergen was obtained by ultrafiltration, Sephadex gel filtration and DE-52 ion exchange chromatography: the purified preparation yields a single band in polyacrylamide gel isoelectric focusing (PAG-IEF), sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting, a single immunoprecipitation arc in crossed immunoelectrophoresis (CIE) and crossed radioimmunoelectrophoresis (CRIE) and a single peak in size exclusion high-performance liquid chromatography (HPLC). Par o I is a glycoprotein with a protein to carbohydrate ratio of 100:21. The molecular weight, determined by SDS-PAGE, Sephadex G-50 gel filtration and size exclusion HPLC, varied between 13.5 and 14.5 kDa according to the method employed. The isoelectric point was 4.6. The amino acid composition and the sequence of the first twelve N-terminal residues were determined. The allergenicity was assayed in vivo and in vitro. 29/29 Parietaria-allergic patients were skin positive to Par o I and possessed high level of specific serum IgE antibody as it determined by radioallergosorbent test (RAST). Par o I contained dominant epitopes for human IgE as inhibited to 85% the pollen extract RAST performed with a pool of sera of allergic patients. The RAST inhibitory activity was not abolished by deglycosylation.
Human Homolog of <b> <i>patched</i> </b> , a Candidate Gene for the Basal Cell Nevus Syndrome (1996)

The basal cell nevus syndrome (BCNS) is characterized by developmental abnormalities and by the postnatal occurrence of cancers, especially basal cell carcinomas (BCCs), the most common human cancer. Heritable mutations in BCNS patients and a somatic mutation in a sporadic BCC were identified in a human homolog of the Drosophila patched (ptc) gene. The ptc gene encodes a transmembrane protein that in Drosophila acts in opposition to the Hedgehog signaling protein, controlling cell fates, patterning, and growth in numerous tissues. The human PTC gene appears to be crucial for proper embryonic development and for tumor suppression.
Phenol Biodegradation by &lt;i&gt;Corynebacterium glutamicum&lt;/i&gt; Encapsulated in Electrospun Fibers (2012)

In Northern Israel, olive mills discharge liquid waste causing contamination of subterranean aquifers with phenol, rendering them albeit temporarily, unfit for both drinking and irrigation. The impact of groundwater pollution due to phenol spillage can be extensive. We developed a model system for the biodegradation of phenol-contaminated wastewater by the bacterium Corynebacterium glutamicum. Experiments consisting of suspended cultures demonstrated the native ability of this organism to utilize phenol for its metabolic pathways enabling degradation, at levels of nearly 100 ppm within 24 hours. With the use of bioinformatic data, a complete degradation pathway was constructed. Quantitative Real Time PCR analysis of the first two enzymes in this pathway revealed very distinct expression patterns and two different regulation mechanisms were postulated. Additionally, an electrospinning core-shell system was used to assemble electrospun microtubes containing bacteria on porous metallic carriers. We used these carriers as a new immobilization technique and demonstrated their significant phenol degrading capacity in a batch bioreactor configuration. This system demonstrates the feasibility of constructing a water treatment system for the management of phenol-contaminated water.
Biosynthesis of a Functional Human Milk Oligosaccharide, 2′-Fucosyllactose, and <scp>l</scp>-Fucose Using Engineered <i>Saccharomyces cerevisiae</i> (2018)

2'-fucosyllactose (2-FL), one of the most abundant human milk oligosaccharides (HMOs), has received much attention due to its health-promoting activities, such as stimulating the growth of beneficial gut microorganisms, inhibiting pathogen infection, and enhancing the host immune system. Consequently, large quantities of 2-FL are on demand for food applications as well as in-depth investigation of its biological properties. Biosynthesis of 2-FL has been attempted primarily in Escherichia coli, which might not be the best option to produce food and cosmetic ingredients due to the presence of endotoxins on the cell surface. In this study, an alternative route to produce 2-FL via a de novo pathway using a food-grade microorganism, Saccharomyces cerevisiae, has been devised. Specifically, heterologous genes, which are necessary to achieve the production of 2-FL from a mixture of glucose and lactose, were introduced into S. cerevisiae. When the lactose transporter (Lac12), de novo GDP-l-fucose pathway (consisting of GDP-d-mannose-4,6-dehydratase (Gmd) and GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase (WcaG)), and α1,2-fucosyltransferase (FucT2) were introduced, the resulting engineered strain (D452L-gwf) produced 0.51 g/L of 2-FL from a batch fermentation. In addition, 0.41 g/L of l-fucose was produced when α-l-fucosidase was additionally expressed in the 2-FL producing strain (D452L-gwf). To our knowledge, this is the first report of 2-FL and l-fucose production in engineered S. cerevisiae via the de novo pathway. This study provides the possibility of producing HMOs by a food-grade microorganism S. cerevisiae and paves the way for more HMO production in the future.
Melatonin replacement corrects sleep disturbances in a child with pineal tumor (1996)

A child with a germ cell tumor involving the pineal region had marked suppression of melatonin secretion associated with severe insomnia. Exogenous melatonin (3 mg in the evening) for 2 weeks restored sleep continuity, as demonstrated by objective monitoring of rest-activity cycles. This case report provides direct evidence of the essential role of melatonin in normal sleep.
High resolution depth reconstruction from monocular images and sparse point clouds using deep convolutional neural network (2017)

Understanding the 3D structure of the environment is advantageous for many tasks in the field of robotics and autonomous vehicles. From the robot’s point of view, 3D perception is often formulated as a depth image reconstruction problem. In the literature, dense depth images are often recovered deterministically from stereo image disparities. Other systems use an expensive LiDAR sensor to produce accurate, but semi-sparse depth images. With the advent of deep learning there have also been attempts to estimate depth by only using monocular images. In this paper we combine the best of the two worlds, focusing on a combination of monocular images and low cost LiDAR point clouds. We explore the idea that very sparse depth information accurately captures the global scene structure while variations in image patches can be used to reconstruct local depth to a high resolution. The main contribution of this paper is a supervised learning depth reconstruction system based on a deep convolutional neural network. The network is trained on RGB image patches reinforced with sparse depth information and the output is a depth estimate for each pixel. Using image and point cloud data from the KITTI vision dataset we are able to learn a correspondence between local RGB information and local depth, while at the same time preserving the global scene structure. Our results are evaluated on sequences from the KITTI dataset and our own recordings using a low cost camera and LiDAR setup.
Analysis of the nucleotide sequence of an invertible controlling element. (1980)

The nucleotide sequence of the inversion region responsible for flagellar phase variation in Salmonella was determined. The inversion region is 995 base pairs (bp) in length and is bounded by a 14-bp inverted repeat sequence. A homologous recombination event between the 14-bp inverted repeat sequences would result in the inversion of the DNA segment between them. Sequence homologies with other systems suggest that the 14-bp inverted repeat sequences may have some general significance as sites for specific recombinational events. The gene which specifies H2 flagellin synthesis begins 16 bp outsie the inversion region. Within the inversion region, an open translational frame exists which could encode a low molecualr weight polypeptide (190 amino acids).
The Impact of Globalization on Agricultural Biotechnology in Iran: A Model for Regional Intellectual Property Rights (2003)

Abstract The increasing population of developing countries, which creates an increasing demand for food, is severely challenging traditional agricultural practices. Recent scientific developments have introduced biotechnology techniques to agriculture. To increase the benefits from implementing biotechnology, countries need both to continuously invest in research and development in their biotechnology sector and to implement a series of complementary policies. Establishing and enforcing the intellectual property rights of plant breeders are among of these policies. The successful institution of plant breeders' rights is influenced by market institutions and the legal system, which together comprise the environmental structure of the economy. Since property rights are not well established in most developing and developed countries, individual research and innovations cannot be protected from intellectual property piracy. As a result, there is little incentive to continue investment in research and development in biotechnology in those markets. This paper proposes a model of regional intellectual property rights for developing countries where individual intellectual property rights are not enforceable.