gebhart/patrepeval huggingface dataset:
Heart rate control of blood pressure variability in children: a study in subjects with fixed ventricular pacemaker rhythm (1998)

1. To investigate the influence of heart rate variability on blood pressure variability, short-term variability in heart rate and blood pressure was studied in 10 children with fixed ventricular pacemaker rhythm (80 beats/min). Ten healthy children, in sinus rhythm, served as a reference population. 2. Arterial blood pressure and heart rate were measured continuously using a finger arterial device and an ECG respectively. Power spectra for heart rate and blood pressure (systolic and diastolic) were calculated in both supine and orthostatic positions. In addition, acute changes in blood pressure and heart rate during active standing were studied. 3. Healthy children exhibited considerable heart rate variability, which was slightly more pronounced in the supine position, while children with a fixed ventricular rate had no heart rate variability in either position. 4. Despite the differences in heart rate variability, mean systolic blood pressure and its variability profiles were poorly affected by the suppression of heart rate variability. The lack of autonomic control on the sinus node was associated with a reduction in magnitude of the changes in systolic blood pressure variability induced by orthostatic posture. 5. The suppression of heart rate fluctuations induced a noticeable decrease in diastolic blood pressure fluctuations, which was most conspicuous in the children with fixed cardiac rhythm when in the supine position. This may be explained by the lack of diastolic blood pressure fluctuations, physiologically due to heart rate fluctuations through the run-off effect: the longer the cardiac cycle, the greater the diastolic pressure decay. These results may challenge the classical theory of baroreflex-mediated diastolic blood pressure control described in adult patients. 6. During active standing, the early drop in systolic blood pressure was greater in subjects with fixed ventricular rhythm. A rise in heart rate of 36 beats/min was observed in the healthy subjects in response to active standing. 7. We conclude that in normal children, heart rate fluctuations increase the blood pressure variability rather than buffering it. However, during acute orthostatic stress, the abrupt baroreflex-mediated heart rate rise may partly compensate for the reduction in blood pressure.
Neuronal and Cognitive Plasticity: A Neurocognitive Framework for Ameliorating Cognitive Aging (2010)

What is the neurocognitive basis for the considerable individual differences observed in functioning of the adult mind and brain late in life? We review the evidence that in healthy old age the brain remains capable of both neuronal and cognitive plasticity, including in response to environmental and experiential factors. Neuronal plasticity (e.g., neurogenesis, synaptogenesis, cortical re-organization) refers to neuron-level changes that can be stimulated by experience. Cognitive plasticity (e.g., increased dependence on executive function) refers to adaptive changes in patterns of cognition related to brain activity. We hypothesize that successful cognitive aging requires interactions between these two forms of plasticity. Mechanisms of neural plasticity underpin cognitive plasticity and in turn, neural plasticity is stimulated by cognitive plasticity. We examine support for this hypothesis by considering evidence that neural plasticity is stimulated by learning and novelty and enhanced by both dietary manipulations (low-fat, dietary restriction) and aerobic exercise. We also examine evidence that cognitive plasticity is affected by education and training. This is a testable hypothesis which could be assessed in humans in randomized trials comparing separate and combined effects of cognitive training, exercise, and diet on measures of cognitive and brain integrity. Greater understanding of the factors influencing the course of cognitive aging and of the mechanisms underlying those factors could provide information on which people could base choices that improve their ability to age successfully.
Electronic Transport Properties of Ruthenium and Ruthenium Dioxide Thin Films (2011)

Resistivities (ρ) and Hall coefficients (RH) of polycrystalline Ru and RuO2 thin films were measured from 293 to 600 K in vacuum, O2, and CO. Differing nanostructures and textures were sputtered at normal, confocal, and glancing incidences to 20–300 nm thickness. For Ru in planar or nanorod morphologies, defects have negligible effect on RH, which is similar to RH in bulk metal. Models of effective thickness are derived for the nanorod morphology. For Ru and RuO 2 films, decreases in ρ on first heating are caused by defect annealing; subsequent heating shows metallic behavior. Changes from n-type to p-type conduction in RuO2 are correlated to grain structures and film strains. For certain RuO2 films, oxygen loss in high vacuum is demonstrated and a RH phase diagram is constructed to reflect the switch in dominant carriers from electrons to holes. Exposure of some RuO 2 films to pure CO is shown to cause an irreversible increase in ρ. Resistivity hysteresis loops after multiple heat cycles with switching from O2 to CO are posited to be consistent with catalysis on Ru rather than RuO2 surfaces. It is shown that switching the gas environment from O2 to CO can change dominant carriers. The physical instability, breakup, and reduction of RuO2 films to Ru metal upon CO exposure is demonstrated.
Phase Noise Characteristics of Fiber Lasers as Potential Ultra-Stable Master Oscillators (2006)

Fourth-generation light sources, such as the European X-Ray Free Electron Laser facility (XFEL), require timing signals distributed over distances of several kilometers with a timing jitter in the order of femtoseconds. The master clock for the proposed optical distribution system must operate with exceptionally low timing jitter. A promising approach is the use of a mode-locked laser that generates ultrastable pulses which are distributed via timing stabilized fiber links. Mode-locked Erbium-doped fiber lasers are attractive candidates, featuring very low noise at high frequencies. In this paper, we present a study of the phase noise of various mode-locked fiber lasers in view of their applicability as laser-based master oscillators for femtosecond-level timing distribution.
Achieving large multiplexing gain in distributed antenna systems via cooperation with pCell technology (2015)

In this paper we present pCellTM technology, the first commercial-grade wireless system that employs cooperation between distributed transceiver stations to create concurrent data links to multiple users in the same spectrum. First we analyze the per-user signal-to-interference-plus-noise ratio (SINR) employing a geometrical spatial channel model to define volumes in space of coherent signal around user antennas (or personal cells, i.e., pCells). Then we describe the system architecture consisting of a general-purpose-processor (GPP) based software-defined radio (SDR) wireless platform implementing a real-time LTE protocol stack to communicate with off-the-shelf LTE devices. Finally we present experimental results demonstrating up to 16 concurrent spatial channels for an aggregate average spectral efficiency of 59.3 bps/Hz in the downlink and 27.5 bps/Hz in the uplink, providing data rates of 200 Mbps downlink and 25 Mbps uplink in 5 MHz of TDD spectrum.
Morphological changes and smooth muscle cell proliferation after experimental excimer laser treatment. (1991)

The proliferative response of SMCs after experimental excimer laser treatment will occur as a dynamic process with a maximum of SMCs undergoing DNA synthesis during 14 days after laser ablation, resulting in an increase of intimal thickening within 4 weeks after laser treatment. The extent of intimal hyperplasia due to SMC proliferation after excimer laser treatment is comparable with the effect of transluminal balloon angioplasty in this experimental model.
Development of Simple Articulated Human Models using Superquadrics for Dynamic Analysis (2011)

Objective: This study is aimed at developing Articulated Human Models(AHM) using superquadrics to improve the geometric accuracy of the body shape. Background: The previous work presents the AHM with geometrical simplification such as ellipsoids to improve analysis efficiency. However, because of the simplicity, their physical properties such as a center of mass and moment of inertia are computed with errors compared to their actual values. Method: This paper introduces a three steps method to present the AHM with superquadrics. First, a 3D whole body scan data are divided into 17 body segments according to body joints. Second, superquadric fitting is employed to minimize the Euclidean distance between body segments and superquadrics. Finally, Fee-Form Deformation is used to improve accuracy over superquadric fitting. Results: Our computational experiment shows that the superquadric models give better accuracy of dynamic analysis than that of ellipsoid ones. Conclusion: We generate the AHM composed of 17 superquadrics and 16 joints using superquadric fitting. Application: The AHM using superquadrics can be used as the base model for dynamics and ergonomics applications with better accuracy because it presents the human motion effectively.
Highly Stable Catalysts for the Stereospecific Polymerization of Styrene (1996)

The synthesis of eight new catalyst precursors is described, and their catalysis of syndiospecific styrene polymerization when activated by methylaluminoxane (MAO) is compared with IndTiCl3. Phenyl substitution increases polymerization activity (A) in the order 1,3-Ph2Ind < 2-PhInd < 1-PhInd; the opposite trend was observed for the yield (SY) of syndiotactic polystyrene (s-PS). The optimum polymerization temperature (Tp) is 50 °C; an increase of Tp decreases A, SY, and molecular weight (MW) of s-PS. Benz[e]IndTiCl3 (6a) as well as the 2-methyl (6b) and 1,2,3-trimethyl (11) derivatives have been synthesized. Complexes 6a/MAO and 6b/MAO have exceedingly high values of A ≈ 1.8 × 108 g of PS/(mol of Ti·mol of styrene·h) for a turnover rate of 450 s-1, SY over 92%, and MW ≈ 5 × 105. These parameters were only slightly lowered at Tp = 100 °C, indicating very thermally stable, catalytically active species. These catalyst precursors are stable in solution toward air and moisture up to 48 h and are indefinitely stable in the solid state. Though 11/MAO has a lower A, it has a higher SY which changes to lesser degrees with increase in Tp than for either 6a or 6b/MAO. Attempts to make benz[f]indenyltrichlorotitanium have so far been unsuccessful.
Investigation of local events of magnetization reversal in a Nd-Fe-B magnet by use of a Hall-effect microprobe (1987)

Magnetization processes in a sintered Nd-Fe-B permanent magnet (NEOMAX-35) were examined on a small scale using a Hall-effect microprobe with an active area 75 μm on a side. Probes were made by evaporating bismuth through a stencil mask onto glass slides. Experiments were performed by placing a probe onto the polished pole face of a Nd-Fe-B magnet and inserting the probe-magnet assembly into an electromagnet. Barkhausen steps, indicating rapid domain wall motion, were observed (superimposed upon the blank probe signal) in the demagnetization of a fully magnetized magnet. Magnetization traces for a thermally demagnetized Nd-Fe-B magnet did not exhibit measurable Barkhausen steps until a field of approximately 1.2 T was applied. The following observations were made for two thermally demagnetized samples which were cycled through minor hysteresis loops (maximum applied field of approximately 2 T). 1) Virgin magnetization traces did not contain measurable Barkhausen steps; however, all other forward and reverse magnetization traces did. 2) The initial reverse magnetization trace exhibited more and larger Barkhausen steps than subsequent traces. 3) Some Barkhausen steps were repeatable, that is, occurring at approximately the same field on each subsequent forward or reverse trace. Hall voltage signals were on the order of millivolts for probe currents of 10 mA.
Application of light-emitting diodes for aerosol fluorescence detection (2003)

We demonstrate a proof-of-concept optical spectroscopic system for bioaerosol-particle fluorescence detection, in which a pulsed high-power laser is replaced by a highly compact linear array of sequentially fired light from blue light-emitting diodes. The results suggest that low-cost, compact optical aerosol detection may be feasible with the contemporary emergence of efficient UV light-emitting diodes.
Laser desorption/ionization mass spectrometry fingerprinting of complex hydrocarbon mixtures: application to crude oils using data mining techniques (2008)

Crude oil fingerprints were obtained from four crude oils by laser desorption/ionization mass spectrometry (LDI-MS) using a silver nitrate cationization reagent. Replicate analyses produced spectral data with a large number of features for each sample (>11,000 m/z values) which were statistically analyzed to extract useful information for their differentiation. Individual characteristic features from the data set were identified by a false discovery rate based feature selection procedure based on the analysis of variance models. The selected features were, in turn, evaluated using classification models. A substantially reduced set of 23 features was obtained through this procedure. One oil sample containing a high ratio of saturated/aromatic hydrocarbon content was easily distinguished from the others using this reduced set. The other three samples were more difficult to distinguish by LDI-MS using a silver cationization reagent; however, a minimal number of significant features were still identified for this purpose. Focus is placed on presenting this multivariate statistical method as a rapid and simple analytical procedure for classifying and distinguishing complex mixtures.
Production of proteinaceous antifungal substances from <i>Lactobacillus brevis</i> NCDC 02 (2009)

Forty standard Lactobacillus cultures were checked for their antifungal properties against nine standard fungi. Yeasts were found to be more resistant than moulds. Lactobacillus brevis NCDC 02 was selected for further studies due to the maximum antifungal activity and proteinaceous nature of antifungal substance production. The optimum production of antifungal substances was at 37°C for 48 h and at the initial pH of 6–7 of the medium. The antifungal substances were heat‐ and pH‐stable. The antifungal substances were found to be hydrophobic and their molecular weight was found to be more than 1 kDa and less than 5 kDa.
Room temperature quantum cascade lasers with 27% wall plug efficiency (2011)

Using the recently proposed shallow-well design, we demonstrate InP based quantum cascade lasers (QCLs) emitting around 4.9 μm with 27% and 21% wall plug efficiencies in room temperature (298 K) pulsed and continuous wave (cw) operations, respectively. The laser core consists of 40 QCL-stages. The highest cw efficiency is obtained from a buried-ridge device with a ridge width of 8 μm and a cavity length of 5 mm. The front and back facets are antireflection and high-reflection coated, respectively. The maximum single facet cw power at room temperature amounts to 5.1 W.
Cure kinetics of biphenyl epoxy resin system using latent catalysts (2001)

Abstract The investigation of the cure kinetics of a biphenyl epoxy–phenol resin system with different kinds of latent catalysts was performed by differential scanning calorimetry using an isothermal approach. All kinetic parameters of the curing reaction including the reaction order, activation energy, and rate constant were calculated and reported. The results indicated that the curing reaction of the biphenyl epoxy resin system in this experiment proceeded through an autocatalytic kinetic mechanism, irrespective of the kind of catalyst. The epoxy resin system with acid/diazabicycloundecene (DBU) salt as the latent catalyst showed a second overall reaction order; however, a third reaction order was represented for microencapsulated triphenylphosphine (TPP). The storage stability tests for these systems were performed, and a good shelf life was observed in the epoxy resin system with pyromellitic acid/DBU salt, trimellitic acid/DBU salt, and microencapsulated TPP as the latent catalyst. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 81: 2711–2720, 2001
Approaches to design non-covalent inhibitors for human granzyme B (hGrB) (2014)

A structure-based design campaign for non-covalent small molecule inhibitors of human granzyme B was carried out by means of a virtual screening strategy employing three constraints and probe site-mapping with FTMAP to identify ligand "hot spots". In addition, new scaffolds of diverse structures were subsequently explored with ROCS shape-based superposition methods, following by Glide SP docking, induced fit docking and analysis of QikProp molecular properties. Novel classes of moderately active small molecule blockers (≥25 μM IC50 values) from commercially available libraries were identified, and three novel scaffolds have been synthesized by multi-step procedures. Furthermore, we provide an example of a comprehensive structure-based drug discovery approach to non-covalent inhibitors that relies on the X-ray structure of a covalently bound ligand and suggest that the design path may be compromised by alternative and unknown binding poses.
Can malaria DNA vaccines on their own be as immunogenic and protective as prime-boost approaches to immunization? (2000)

To develop a multi-stage, multi-antigen, multi-immune response-inducing vaccine against malaria we have focused on DNA vaccines because of their simplicity of construction and modification, ease of mixing, and effectiveness in inducing CD8+ T cell responses. DNA malaria vaccines induce CD8+ T cell dependent protection in mice and CD8+ CTL in rhesus monkeys and humans after intramuscular needle administration. Clinical trials in normal, healthy humans are in progress or planned, assessing alternative methods and routes of administration, and the capacity of a plasmid expressing human GM-CSF to enhance the protective efficacy of a five-gene liver-stage malaria vaccine. In mice, we have demonstrated that priming with the combination of DNA plasmids encoding a Plasmodium yoelii protein and murine GM-CSF and boosting with recombinant poxvirus expressing the same P. yoelii protein induces a 30-fold increase in antigen-specific antibodies, a 10-fold increase in antigen-specific IFN-gamma spot forming cells, a significant (p<0.05) increase in protection, and the capacity to reduce the dosage of DNA by 10-100 fold, compared to immunizing with DNA alone. In Aotus monkeys priming with DNA and boosting with recombinant protein in adjuvant is more protective than homologous priming and boosting with either DNA or recombinant protein in adjuvant. Clinical trials are now planned using these immunization strategies. Because of the complexity and cost of the heterologous regimens, we are working to make DNA vaccination alone as immunogenic and protective as the prime-boost approach. Our most encouraging findings have resulted from altering codon usage from the highly A+T rich P. falciparum native sequence to that more closely resembling mammalian sequences. Although much progress is required for the development of a vaccine that provides sustainable protective immunity against malaria, a strategy using DNA vaccine technology as a core component of such a vaccine is promising.
Multiplexing and demultiplexing with photonic crystals (1999)

International audience
Fast and Accurate Method for Quantitating <i>E. Coli</i> Host-Cell DNA Contamination in Plasmid DNA Preparations (1999)

Plasmid DNA is being used successfully as a gene delivery vector in a variety of clinical applications. Similar to other pharmaceutical products for clinical use, the plasmid vectors must meet rigorous purity standards. One important contaminant is the DNA of the host cell used to produce the plasmids. We have developed a new method to accurately quantitate E. coli host-cell DNA in plasmid preparations. This method is based on kinetic PCR using the ABI PRISM 7700 with 23S rDNA as a target. This precise assay is significantly faster and has a lower limit of quantitation than the currently used Southern-based methods.
Image-based feedback control for real-time sorting of microspheres in a microfluidic device (2010)

We describe a control system to automatically distribute antibody-functionalized beads to addressable assay chambers within a PDMS microfluidic device. The system used real-time image acquisition and processing to manage the valve states required to sort beads with unit precision. The image processing component of the control system correctly counted the number of beads in 99.81% of images (2689 of 2694), with only four instances of an incorrect number of beads being sorted to an assay chamber, and one instance of inaccurately counted beads being improperly delivered to waste. Post-experimental refinement of the counting script resulted in one counting error in 2694 images of beads (99.96% accuracy). We analyzed a range of operational variables (flow pressure, bead concentration, etc.) using a statistical model to characterize those that yielded optimal sorting speed and efficiency. The integrated device was able to capture, count, and deliver beads at a rate of approximately four per minute so that bead arrays could be assembled in 32 individually addressable assay chambers for eight analytical measurements in duplicate (512 beads total) within 2.5 hours. This functionality demonstrates the successful integration of a robust control system with precision bead handling that is the enabling technology for future development of a highly multiplexed bead-based analytical device.
Malware Defense Using Network Security Authentication (2005)

Malware defenses have primarily relied upon intrusion fingerprints to detect suspicious network behavior. While effective for discovering computers that are already compromised, these systems are not designed to stop the spread or damage of malware. Standard gateway firewalls can prevent outside-based attacks; however, they are ineffective in a mobile network where threats originate from inside and administrators have limited control over client machines. This paper introduces a new strategy for malware defense using security authentication which focuses on vulnerabilities rather than exploits. The proposed system uses a remote security scanner to check for vulnerabilities and quarantines machines using logical network segmentation. This maximizes the usefulness of the machine in question while preventing attacks. Furthermore given the unique ability to quarantine machines without any specialized host software, the proposed system can defend against internal malware threats in a mobile network. Positive results have been achieved utilizing a proof-of-concept model and standard networking tools.
Optical frequency tuning by laser-irradiation in silica-based March-Zehnder-type multi/demultiplexers (1991)

Optical frequency tuning due to photoinduced refractive-index changes is described in Mach-Zehnder interferometer-type frequency division multiplexers (FDMs) which are composed of GeO/sub 2-/silica-based waveguides on Si substrates. A maximum refractive-index change of about 4*10/sup -5/ at 1.3 mu m is obtained at an Ar/sup +/ laser power of 20 W and an irradiation time of 1 h. This leads to frequency tuning of more than half a period in FDM with a free spectral range of 25 GHz. In addition, the annealing effects on the refractive-index change are investigated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>