gebhart/patrepeval huggingface dataset:
Problemanregung (2001)

Problembewußtsein wird in der Regel durch Hinweise auf verfehlte Ziele bzw. Soll-Ist-Abweichungen geschaffen.1 Derartige Symptome für Fehlentwicklungen können als Risiko oder als Chance empfunden werden und sind Ausgangspunkt und Voraussetzung für unternehmerische Planungs- und Entscheidungsprozesse.2
Validating Tools for Cell Phone Forensics (2008)

As mobile devices grow in popularity and ubiquity in everyday life, they are often vulnerable in security and privacy. Cell phones, for instance, have been a target of spam and harassment. Sometimes, they become a media or tool in criminal cases or in corporate investigation. Cellular phone forensics is therefore important for law enforcement and private investigators. Cell phone forensics aims at acquiring and analyzing data in the cellular phone, which is similar to computer forensics. However, the forensic tools for cell phones are quite different from those for personal computers. One of the challenges in this area is the lack of a validation procedure for forensic tools to determine their effectiveness. This paper presents our preliminary research in creating a baseline for testing forensic tools. This research was accomplished by populating test data onto a cell phone (either manually or with an Identity Module Programmer) and then various tools effectiveness will be determined by the percentage of that test data retrieved. This study will lay a foundation for further research in this field. This research could be expanded further in several ways: First, while we were using a locked T-Mobile standard SIM card thus the amount of change that can be done is limited, a test SIM card or a Smart card which is unlocked will provide for a greater range of area for data to be written. Second, a SIM card writer or an identity module programmer for direct writing onto a SIM card would also allow for population for a greater range of element files. Third, open source SIM card writers or identity module programmers and SIM card readers would be more ideal for reading/obtaining data and writing data so researchers have the ability to look at as well as modify code.
Advanced Jet Protocols for Directly Engineering Living Cells: A Genesis to Alternative Biohandling Approaches for the Life Sciences (2007)

Processing methodologies possessing the ability to directly handle living cells imply tremendous possibilities for a whole host of applications in the regenerative and therapeutic medicinal themes of R&D. Most cell-handling techniques have, in the past, been unearthed in the physical sciences, which have subsequently undergone rapid development for a plethora of applications within the life sciences. In this review, the author wishes to introduce current and swiftly emerging direct cell-handling jet protocols whilst identifying their advantages and disadvantages in comparison to each approach. The article extends to elucidating their applicability for a few life science-based research themes, where these protocols are currently undergoing intense investigation. It is the opinion of this author that these protocols generate a range of opportunities for the life sciences, which have previously not been explored and hence could have an overwhelming affect in a biological and clinical standpoint. These methods and protocols have evidently bridged the physical with the life sciences during this endeavor.
Mathematics of Derivative Securities (1997)

During 1995 the Isaac Newton Institute for the Mathematical Sciences at Cambridge University hosted a six month research program on financial mathematics. During this period more than 300 scholars and financial practitioners attended to conduct research and to attend more than 150 research seminars. Many of the presented papers were on the subject of financial derivatives. The very best were selected to appear in this volume. They range from abstract financial theory to practical issues pertaining to the pricing and hedging of interest rate derivatives and exotic options in the market place. Hence this book will be of interest to both academic scholars and financial engineers.
Development of an AmpliSeqTM Panel for Next-Generation Sequencing of a Set of Genetic Predictors of Persisting Pain (2018)

<b>Background:</b> Many gene variants modulate the individual perception of pain and possibly also its persistence. The limited selection of single functional variants is increasingly being replaced by analyses of the full coding and regulatory sequences of pain-relevant genes accessible by means of next generation sequencing (NGS). <b>Methods:</b> An NGS panel was created for a set of 77 human genes selected following different lines of evidence supporting their role in persisting pain. To address the role of these candidate genes, we established a sequencing assay based on a custom AmpliSeq<sup>TM</sup> panel to assess the exomic sequences in 72 subjects of Caucasian ethnicity. To identify the systems biology of the genes, the biological functions associated with these genes were assessed by means of a computational over-representation analysis. <b>Results:</b> Sequencing generated a median of 2.85 ⋅ 10<sup>6</sup> reads per run with a mean depth close to 200 reads, mean read length of 205 called bases and an average chip loading of 71%. A total of 3,185 genetic variants were called. A computational functional genomics analysis indicated that the proposed NGS gene panel covers biological processes identified previously as characterizing the functional genomics of persisting pain. <b>Conclusion:</b> Results of the NGS assay suggested that the produced nucleotide sequences are comparable to those earned with the classical Sanger sequencing technique. The assay is applicable for small to large-scale experimental setups to target the accessing of information about any nucleotide within the addressed genes in a study cohort.
Applying Inference Networks for Multiple Collection Searching (1996)

The paper describes how to use inference networks to solve two problems in searching multiple collections: collection selection and result merging. The effectiveness of the approaches is demonstrated with the INQUERY system and 3 gigabyte TREC collections. 1 Introduction As hundreds or even thousands of collections are available on the Internet, the IR community must cope with the problem of searching multiple collection. The simplest approach is to build a single index for all collections. But this approach is practically prohibited by its obvious drawback: it is too slow, because searching such a gigantic index takes a long time to complete. Worse, this search may not complete due to network resource limits, such as limited bandwidth in the case of hundreds of collections. One way to get a quick response is to narrow the search to a portion of the index, which leads to a partition of the index. The natural way to partition is for each partition to correspond to one collection. Heuri...
2010-12: The Market Sensitivity of Australian Superannuation Socially Responsible Investment Funds. Evidence from a Markov Regime Switching Approach (Working paper) (2010)

An increasing proportion of Australian superannuation funds are being placed in socially responsible investments (SRI). However, there is no clarity yet in the literature as regards the risk and return characteristics of these investments. In this paper, we examine the sensitivity of Australian SRI funds to movements in the Australian and US equity markets and SRI sectors under different states of the markets through the application of Markov regime switching analysis. We find that, just like their non- SRI counterparts, Australian superannuation SRI funds are mostly driven by the US equity market and to a lesser extent by the Australian equity market and are also not successful in timing the market. Further, we find that the US, but not the Australian, SRI sector is a source of systematic risk for Australian superannuation SRI funds.
Robust characterization of the DC-conductivity of HVDC insulation materials at high electric fields (2015)

Robust characterization of the DC-conductivity of HVDC insulation materials at high electric fields
Zeno hybrid systems (2001)

Abstract The interacting continuous and discrete dynamics in hybrid systems may lead to Zeno executions, which are solutions of the system having infinitely many discrete transitions in finite time. Although physical systems do not show Zeno behaviour, models of real systems may be Zeno due to modelling abstraction. It is hard to analyse such models with the existing theory. Since abstraction is an important tool in the hierarchical design of hybrid systems, one would like to determine when it may lead to Zeno models. Zeno hybrid systems are studied in detail in the paper. Necessary and sufficient conditions for the existence of Zeno executions are given. The Zeno set is introduced as the ω limit set of a Zeno execution. Properties of the Zeno set are derived for a fairly large class of hybrid systems. Copyright 2001 © John Wiley & Sons, Ltd.
Bradley-Terry Models in<i>R</i>: The<b>BradleyTerry2</b>Package (2012)

This is a short overview of the R add-on package BradleyTerry2, which facilitates the specification and fitting of Bradley-Terry logit, probit or cauchit models to paircomparison data. Included are the standard ‘unstructured’ Bradley-Terry model, structured versions in which the parameters are related through a linear predictor to explanatory variables, and the possibility of an order or ‘home advantage’ effect or other ‘contest-specific’ effects. Model fitting is either by maximum likelihood, by penalized quasi-likelihood (for models which involve a random effect), or by bias-reduced maximum likelihood in which the first-order asymptotic bias of parameter estimates is eliminated. Also provided are a simple and efficient approach to handling missing covariate data, and suitably-defined residuals for diagnostic checking of the linear predictor.
Effects of forage:concentrate ratio and forage type on apparent digestibility, ruminal fermentation, and microbial growth in goats1 (2008)

The effects of forage type and forage:concentrate ratio (F:C) on apparent nutrient digestibility, ruminal fermentation, and microbial growth were investigated in goats. A comparison between liquid (LAB) and solid (SAB)-associated bacteria to estimate microbial N flow (MNF) from urinary purine derivative excretion was also examined. Treatments were a 2 x 2 factorial arrangement of forage type (grass hay vs. alfalfa hay) and high vs. low F:C (70:30 and 30:70, respectively). Four ruminally cannulated goats were fed, at maintenance intake, 4 experimental diets according to a 4 x 4 Latin square design. High-concentrate diets resulted in greater (P < 0.001) nutrient digestibility except for ADF. However, CP digestibility increased (P < 0.001) only for the high-concentrate diets including grass hay. Likewise, N retention, ruminal NH(3)-N concentration, and urinary excretion of purine derivatives increased (P < 0.05) with increasing concentrate in animals fed diets based on grass hay (0.23 vs. 0.13 g of retained N/g of digested N, 30.1 vs. 12.9 mg of NH(3)-N/100 mL, and 11.5 vs. 8.40 mmol/d, respectively), but not (P > 0.05) when diets included alfalfa hay. Total protozoa numbers and holotricha proportion were greater and less (P < 0.001), respectively, in high- than in low-concentrate diets. The F:C affected (P < 0.001) ruminal pH but not total VFA concentration (P = 0.12). Ammonia-N concentration was similar (P = 0.13) over time, whereas pH, VFA concentration, and protozoa numbers differed (P < 0.001) among diets. Estimated MNF was strongly influenced by using either the purine bases:N ratio obtained in our experimental conditions or values reported in the literature for small ruminants. There was a F:C effect (P = 0.006) on MNF estimated from LAB but not from SAB. The effect of F:C shifting from 70:30 to 30:70 in goat diets depends on the type of forage used. The MNF measured in goats fed different diets was influenced by the bacterial pellet (LAB or SAB). In addition, the purine bases:N ratio values found were different from those reported in the literature, which underlines the need for these variables to be analyzed directly in pellets isolated from specific animals and experimental conditions.
Purification of a 60 kDa Nuclear Localization Signal Binding Protein in Rat Liver Nuclear Envelopes and Characterization of Its Properties (1993)

A nuclear localization signal binding protein in nuclear envelope was studied as the first step to determine the mechanism of nuclear protein recognition by nuclear envelope. The rat liver nuclear envelope extract was resolved by SDS-PAGE and ligand blotted with 125I-labeled nucleoplasmin bearing a strong nuclear localization signal. A nuclear localization signal binding protein with molecular mass of 60 kDa (NBP60) was detected in the extract. NBP60 could be extracted with 2% Triton X-100-1 M KCl but not with 1 M KCl, 2 M urea, or 2% Triton X-100. The protein was partitioned to the lower layer in a two phase system using Triton X-114. These results suggested that the protein is an intrinsic membrane protein and has a hydrophobic surface. This protein was bound to not only nucleoplasmin but also the nuclear localization signal peptide of SV 40 large T-antigen (T-peptide) conjugated to human serum albumin. The binding of NBP60 to nucleoplasmin-Sepharose was inhibited by 50% in the presence of 0.12 mM T-peptide. However, a high concentration of 2.1 mM was necessary, when mutant T-peptide in which the essential amino acid lysine was substituted with threonine was used. These results suggested that NBP60 binds specifically to nuclear localization signals. NBP60 extracted from the nuclear envelope was purified by nucleoplasmin-Sepharose affinity chromatography following hydroxyapatite high performance liquid chromatography.
Morphological and Physiological Changes during Thidiazuron-Induced Somatic Embryogenesis in Geranium (Pelargonium x hortorum Bailey) Hypocotyl Cultures (1996)

Somatic embryogenesis in geranium (Pelargonium x hortorum Bailey cv. Scarlet Orbit Improved) was achieved by culturing hypocotyl explants on media supplemented with either thidiazuron (TDZ) or indol-3-yl-acetic acid (IAA) and 6-benzylaminopurine (BAP). The physiological relationships between the morphological changes that lead to complete development of somatic embryos and the endogenous levels of plant growth regulators were studied. TDZ induced similar but more pronounced and earlier morphological changes in cultured tissues than did IAA and BAP, but after 21 d in culture, both treatments promoted the formation of somatic embryos of different developmental stages that were similar to zygotic embryos. TDZ induced a higher number of somatic embryos, with similar but greater increases in the endogenous levels of auxins and cytokinins, than did IAA and BAP. This may indicate that TDZ may be a more potent plant growth regulator in inducing physiological and morphological changes than combined auxin and cytokinin, during the process of somatic embryogenesis in geranium.
Detergent/Nanodisc Screening for High-Resolution NMR Studies of an Integral Membrane Protein Containing a Cytoplasmic Domain (2013)

Because membrane proteins need to be extracted from their natural environment and reconstituted in artificial milieus for the 3D structure determination by X-ray crystallography or NMR, the search for membrane mimetic that conserve the native structure and functional activities remains challenging. We demonstrate here a detergent/nanodisc screening study by NMR of the bacterial α-helical membrane protein YgaP containing a cytoplasmic rhodanese domain. The analysis of 2D [(15)N,(1)H]-TROSY spectra shows that only a careful usage of low amounts of mixed detergents did not perturb the cytoplasmic domain while solubilizing in parallel the transmembrane segments with good spectral quality. In contrast, the incorporation of YgaP into nanodiscs appeared to be straightforward and yielded a surprisingly high quality [(15)N,(1)H]-TROSY spectrum opening an avenue for the structural studies of a helical membrane protein in a bilayer system by solution state NMR.
“Electron/Ion Sponge”-Like V-Based Polyoxometalate: Toward High-Performance Cathode for Rechargeable Sodium Ion Batteries (2017)

One key challenge facing room temperature Na-ion batteries lies in identifying earth-abundant, environmentally friendly and safe materials that can provide efficient Na<sup>+</sup> storage sites in Na-ion batteries. Herein, we report such a material, polyoxometalate Na<sub>2</sub>H<sub>8</sub>[MnV<sub>13</sub>O<sub>38</sub>] (NMV), with entirely different composition and structure from those cathode compounds reported before. Ex-situ XPS and FTIR analyses reveal that NMV cathode behaves like an "electron/Na-ion sponge", with 11 electrons/Na<sup>+</sup> acceptability per mole, which has a decisive contribution to the high capacity. The extraordinary structural features, evidenced by X-ray crystallographic analysis, of Na<sub>2</sub>H<sub>8</sub>[MnV<sub>13</sub>O<sub>38</sub>] with a flexible 2D lamellar network and 1D open channels provide diverse Na ion migration pathways, yielding good rate capability. First-principle calculations demonstrate that a super-reduced state, [MnV<sub>13</sub>O<sub>38</sub>]<sup>20-</sup>, is formed with slightly expanded size (ca. 7.5%) upon Na<sup>+</sup> insertion compared to the original [MnV<sub>13</sub>O<sub>38</sub>]<sup>9-</sup>. This "ion sponge" feature ensures the good cycling stability. Consequently, benefiting from the combinations of "electron/ion sponge" with diverse Na<sup>+</sup> diffusion channels, when revealed as the cathode materials for Na-ion batteries, Na<sub>2</sub>H<sub>8</sub>[MnV<sub>13</sub>O<sub>38</sub>]/G exhibits a high specific capacity (ca. 190 mA h/g at 0.1 C), associates with a good rate capability (130 mA h/g at 1 C), and a good capacity retention (81% at 0.2 C). Our results promote better understanding of the storage mechanism in polyoxometalate host, enrich the existing rechargeable SIBs cathode chemistry, and enlighten an exciting direction for exploring promising cathode materials for Na-ion batteries.
Structure−Activity Investigation on the Gene Transfection Properties of Cardiolipin Mimicking Gemini Lipid Analogues (2008)

A structure-activity relationship has been explored on the gene transfection efficiencies of cardiolipin mimicking gemini lipid analogues upon variation of length and hydrophilicity of the spacer between the cationic ammonium headgroups and lipid hydrocarbon chain lengths. All the gemini lipids were found to be highly superior in gene transfer abilities as compared to their monomeric lipid and a related commercially available formulation. Pseudoglyceryl gemini lipids bearing an oxyethylene (-CH2-(CH2-O-CH2)m-CH2-) spacer were found to be superior gene transfecting agents as compared to those bearing polymethylene (-CH2)m-) spacers. The major characteristic feature of the present set of gemini lipids is their serum compatibility, which is most often the major hurdle in liposome-mediated gene delivery.
The SET Protein Regulates G2/M Transition by Modulating Cyclin B-Cyclin-dependent Kinase 1 Activity (2003)

The SET protein and the cell cycle inhibitor p21(Cip1) interact in vivo and in vitro. We identified here the domain (157)LIF(159) of p21(Cip1) as essential for the binding of SET. We also found that SET contains at least two domains of interaction with p21(Cip1), one located in the fragment amino acids 81-180 and the other one in the fragment including amino acids 181-277. SET and p21(Cip1) co-localize in the cell nucleus in a temporal manner. Overexpression of SET blocks the cell cycle at the G(2)/M transition in COS and HCT116 cells. Moreover, SET inhibits cyclin B-CDK1 activity both in vivo and in vitro in both cell types. This effect is specific for these complexes since SET did not inhibit either cyclin A-CDK2 or cyclin E-CDK2 complexes. SET and p21(Cip1) cooperate in the inhibition of cyclin B-CDK1 activity. The inhibitory effect of SET resides in its acidic C terminus, as demonstrated by the ability of this domain to inhibit cyclin B-CDK1 activity and by the lack of blocking G(2)/M transition when a mutated form of SET lacking this C terminus domain was overexpressed in COS cells. These results indicate that SET might regulate G(2)/M transition by modulating cyclin B-CDK1 activity.
Propionicins, bacteriocins produced by Propionibacterium avidum. (1978)

One hundred strains of Propionibacterium acnes, granulosum and avidum were tested for susceptibility toward bacteriocins produced extracellularly by eight strains of Propionibacterium avidum. Some bacteriocin-producing strains were inhibitory for all strains tested. A name propionicins, is proposed for bacteriocins produced by P. avidum.
Confidentiality and Differential Privacy in the Dissemination of Frequency Tables (2018)

For decades, national statistical agencies and other data custodians have been publishing frequency tables based on census, survey and administrative data. In order to protect the confidentiality of individuals represented in the data, tables based on original data are modified before release. Recently, in response to user demand for more flexible and responsive table publication services, frequency table publication schemes have been augmented with on-line table generating servers such as the US Census Bureau FactFinder and the Australian Bureau of Statistics (ABS) TableBuilder. These systems allow users to build their own custom tables, and make use of automated perturbation routines to protect confidentiality. Motivated by the growing popularity of table generating servers, in this paper we study confidentiality protection for perturbed frequency tables, including the trade-off with analytical utility, focusing on a version of the ABS TableBuilder as a concrete example of a data release mechanism, and examining its properties. Confidentiality protection is assessed in terms of the differential privacy standard, and this paper can be used as a practical introduction to differential privacy, to calculations related to its application, to the relationship between confidentiality protection and utility and to confidentiality in general.
A multistage representation of the Wiener filter based on orthogonal projections (1998)

The Wiener filter is analyzed for stationary complex Gaussian signals from an information theoretic point of view. A dual-port analysis of the Wiener filter leads to a decomposition based on orthogonal projections and results in a new multistage method for implementing the Wiener filter using a nested chain of scalar Wiener filters. This new representation of the Wiener filter provides the capability to perform an information-theoretic analysis of previous, basis-dependent, reduced-rank Wiener filters. This analysis demonstrates that the cross-spectral metric is optimal in the sense that it maximizes mutual information between the observed and desired processes. A new reduced-rank Wiener filter is developed based on this new structure which evolves a basis using successive projections of the desired signal onto orthogonal, lower dimensional subspaces. The performance is evaluated using a comparative computer analysis model and it is demonstrated that the low-complexity multistage reduced-rank Wiener filter is capable of outperforming the more complex eigendecomposition-based methods.