gebhart/patrepeval huggingface dataset:
Regulation of the hepatic microsomal glucose-6-phosphatase enzyme (1992)

Conference Article| August 01 1992 Regulation of the hepatic microsomal glucose-6-phosphatase enzyme HELEN LYALL; HELEN LYALL 1Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, Dundee, DD1 9SY. Search for other works by this author on: This Site PubMed Google Scholar ANGELA GRANT; ANGELA GRANT 1Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, Dundee, DD1 9SY. Search for other works by this author on: This Site PubMed Google Scholar HAZEL M. SCOTT; HAZEL M. SCOTT 1Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, Dundee, DD1 9SY. Search for other works by this author on: This Site PubMed Google Scholar ANN BURCHELL ANN BURCHELL 1Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, Dundee, DD1 9SY. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1992) 20 (3): 271S. https://doi.org/10.1042/bst020271s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation HELEN LYALL, ANGELA GRANT, HAZEL M. SCOTT, ANN BURCHELL; Regulation of the hepatic microsomal glucose-6-phosphatase enzyme. Biochem Soc Trans 1 August 1992; 20 (3): 271S. doi: https://doi.org/10.1042/bst020271s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1992 Biochemical Society1992 Article PDF first page preview Close Modal You do not currently have access to this content.
Regulation of Cell Division, Biofilm Formation, and Virulence by FlhC in Escherichia coli O157:H7 Grown on Meat (2011)

To understand the continuous problems that Escherichia coli O157:H7 causes as food pathogen, this study assessed global gene regulation in bacteria growing on meat. Since FlhD/FlhC of E. coli K-12 laboratory strains was previously established as a major control point in transducing signals from the environment to several cellular processes, this study compared the expression pattern of an E. coli O157:H7 parent strain to that of its isogenic flhC mutant. This was done with bacteria that had been grown on meat. Microarray experiments revealed 287 putative targets of FlhC. Real-time PCR was performed as an alternative estimate of transcription and confirmed microarray data for 13 out of 15 genes tested (87%). The confirmed genes are representative of cellular functions, such as central metabolism, cell division, biofilm formation, and pathogenicity. An additional 13 genes from the same cellular functions that had not been hypothesized as being regulated by FlhC by the microarray experiment were tested with real-time PCR and also exhibited higher expression levels in the flhC mutant than in the parent strain. Physiological experiments were performed and confirmed that FlhC reduced the cell division rate, the amount of biofilm biomass, and pathogenicity in a chicken embryo lethality model. Altogether, this study provides valuable insight into the complex regulatory network of the pathogen that enables its survival under various environmental conditions. This information may be used to develop strategies that could be used to reduce the number of cells or pathogenicity of E. coli O157:H7 on meat by interfering with the signal transduction pathways.
3D nongadolinium‐enhanced ECG‐gated MRA of the distal lower extremities: Preliminary clinical experience (2008)

Our results indicate that when technically successful, noncontrast-enhanced MRA using ECG-gated fast spin echo can provide accurate imaging of the calf and pedal arteries. However, further development and optimization are needed to improve the robustness of the technique.
Design and Implementation of FIR Filters (2006)

This chapter contains sections titled: Introduction to FIR Filters Design of FIR Filters Implementation Considerations Applications: Interpolation and Decimation Filters Experiments and Program Examples References Exercises
Intersection of Inflammation and Herbal Medicine in the Treatment of Osteoarthritis (2012)

Herbal remedies and dietary supplements have become an important area of research and clinical practice in orthopaedics and rheumatology. Understanding the risks and benefits of using herbal medicines in the treatment of arthritis, rheumatic diseases, and musculoskeletal complaints is a key priority of physicians and their patients. This review discusses the latest advances in the use of herbal medicines for treating osteoarthritis (OA) by focusing on the most significant trends and developments. This paper sets the scene by providing a brief introduction to ethnopharmacology, Ayurvedic medicine, and nutrigenomics before discussing the scientific and mechanistic rationale for targeting inflammatory signalling pathways in OA by use of herbal medicines. Special attention is drawn to the conceptual and practical difficulties associated with translating data from in-vitro experiments to in-vivo studies. Issues relating to the low bioavailability of active ingredients in herbal medicines are discussed, as also is the need for large-scale, randomized clinical trials.
An electron beam line probe with variable aspect ratio (1990)

This paper presents a concept for using a line source in combination with quadrupole lenses, operated with a stigmatic focus, to produce a variable aspect ratio line probe. Using a quadrupole doublet and triplet the aspect ratio of a line probe may be varied from 1:1 to 100:1 with high resolution. The quadrupole lenses were considered in two locations: near the source as in conventional shaping optics and as a final lens. The first order optical properties and third order aberrations were calculated to show the feasibility of this concept.
Inducible nitric oxide synthase in T cells regulates T cell death and immune memory (2004)

The progeny of T lymphocytes responding to immunization mostly die rapidly, leaving a few long-lived survivors functioning as immune memory. Thus, control of this choice of death versus survival is critical for immune memory. There are indications that reactive radicals may be involved in this death pathway. We now show that, in mice lacking inducible nitric oxide synthase (iNOS), higher frequencies of both CD4 and CD8 memory T cells persist in response to immunization, even when iNOS(+/+) APCs are used for immunization. Postactivation T cell death by neglect is reduced in iNOS(-/-) T cells, and levels of the antiapoptotic proteins Bcl-2 and Bcl-xL are increased. Inhibitors of the iNOS-peroxynitrite pathway also enhance memory responses and block postactivation death by neglect in both mouse and human T cells. However, early primary immune responses are not enhanced, which suggests that altered survival, rather than enhanced activation, is responsible for the persistent immunity observed. Thus, in primary immune responses, iNOS in activated T cells autocrinely controls their susceptibility to death by neglect to determine the level of persisting CD4 and CD8 T cell memory, and modulation of this pathway can enhance the persistence of immune memory in response to vaccination.
Birch: A Metadata Search File System (2006)

We preset a dynamic file system for Mac OS X that renders Spotlight metadata search results as files and directories, and describe the issues that arose in developing this system, and the lessons learned about the usability and performance of such a system.
Regulation of Chromosome Segregation by Glc8P, a Structural Homolog of Mammalian Inhibitor 2 That Functions as both an Activator and an Inhibitor of Yeast Protein Phosphatase 1 (1995)

The Ipl1 protein kinase is essential for proper chromosome segregation and cell viability in the budding yeast Saccharomyces cerevisiae. We have previously shown that the temperature-sensitive growth phenotype of conditional ipl1-1ts mutants can be suppressed by a partial loss-of-function mutation in the GLC7 gene, which encodes the catalytic subunit (PP1C) of protein phosphatase 1, thus suggesting that this enzyme acts in opposition to the Ipl1 protein kinase in regulating yeast chromosome segregation. We report here that the Glc8 protein, which is related in primary sequence to mammalian inhibitor 2, also participates in this regulation. Like inhibitor 2, the Glc8 protein is heat stable, exhibits anomalous electrophoretic mobility, and functions in vitro as an inhibitor of yeast as well as rabbit skeletal muscle PP1C. Interestingly, overexpression as well as deletion of the GLC8 gene results in a partial suppression of the temperature-sensitive growth phenotype of ipl1ts mutants and also moderately reduces the amount of protein phosphatase 1 activity which is assayable in crude yeast lysates. In addition, the chromosome missegregation phenotype caused by an increase in the dosage of GLC7 is totally suppressed by the glc8-delta 101::LEU2 deletion mutation. These findings together suggest that the Glc8 protein is involved in vivo in the activation of PP1C and that when the Glc8 protein is overproduced, it may also inhibit PP1C function. Furthermore, site-directed mutagenesis studies of GLC8 suggest that Thr-118 of the Glc8 protein, which is equivalent to Thr-72 of inhibitor 2, may play a central role in the ability of this protein to activate and/or inhibit PP1C in vivo.
What is Coordination Theory (1988)

HD28 .M414 no.2051-, 88,
The Scalable Extensions of HEVC for Ultra-High-Definition Video Delivery (2014)

This article presents an overview of SHVC, the scalable extension of H.265/HEVC. SHVC adopts a scalable coding architecture with only high-level syntax changes relative to its base codec, which allows SHVC to be deployed with significantly reduced implementation cost. SHVC supports a rich set of scalability features. It also addresses the increasing market demand for higher quality and higher value video content delivery by providing a set of desired scalability features with high coding efficiency.
Single-Molecule Analysis Reveals Changes in the DNA Replication Program for the <i>POU5F1</i> Locus upon Human Embryonic Stem Cell Differentiation (2010)

Human embryonic stem cells (hESCs), due to their pluripotent nature, represent a particularly relevant model system to study the relationship between the replication program and differentiation state. Here, we define the basic properties of the replication program in hESCs and compare them to the programs of hESC-derived multipotent cells (neural rosette cells) and primary differentiated cells (microvascular endothelial cells [MECs]). We characterized three genomic loci: two pluripotency regulatory genes, POU5F1 (OCT4) and NANOG, and the IGH locus, a locus that is transcriptionally active specifically in B-lineage cells. We applied a high-resolution approach to capture images of individual replicated DNA molecules. We demonstrate that for the loci studied, several basic properties of replication, including the average speed of replication forks and the average density of initiation sites, were conserved among the cells analyzed. We also demonstrate, for the first time, the presence of initiation zones in hESCs. However, significant differences were evident in other aspects of replication for the DNA segment containing the POU5F1 gene. Specifically, the locations of centers of initiation zones and the direction of replication fork progression through the POU5F1 gene were conserved in two independent hESC lines but were different in hESC-derived multipotent cells and MECs. Thus, our data identify features of the replication program characteristic of hESCs and define specific changes in replication during hESC differentiation.
Oxidation of p–xylene to terephthalic acid in benzoic acid and methyl ester of p–toluic acid (1987)

The oxidation of p -xylene to terephthalic acid has been studied at 130 to 190 °C, using benzoic acid and methyl ester of p -toluic acid as the solvent. It was found that the solvent affects strongly the activity of the cobalt catalyst which effect is dependent on the presence of bromide and pyridine ligands. In the methyl ester of p -toluic acid as the solvent, cobalt-bromide catalysts induce also hydrolysis of the methyl ester which proceeds parallelly to the oxidation of p -xylene. The activating effect of bromide and pyridine ligands results from their effect on the rate of the reaction of peroxy radicals with the catalyst in the propagation step and from their effect on the rate of consecutive oxidation of p -toluic acid to terephthalic acid.
Iterative Polynomial Fitting Technique Using Polynomial Coefficients for the Nonlinear Line Array Shape Estimation (2006)

Low frequency towed line array with high array gain and beam resolution is a long range surveillance sensor for anti-submarine warfare. The beam characteristics is however deteriorated due to the distorted line array sensor caused by low towing speed, wind, current, and towing ship maneuvering. An adaptive beamforming method is utilized in this paper to enhance the distorted line array beam performance by estimating and compensating the nonlinear array shape. A polynomial curve fitting in the least square sense is used to estimate the array shape iteratively with the distributed heading sensors data along the array. Real time array shape estimation and nonlinear array beam calculation is applied to a very long towed line array sensor system and the beam performance is evaluated and compared to the linear beamformer for the simulation and sea trial data.
Heterogeneously integrated sub-40nm low-power epi-like Ge/Si monolithic 3D-IC with stacked SiGeC ambient light harvester (2014)

For the first time, we report heterogeneously integrated sub-40nm epi-like Ge/Si monolithic 3D-IC with low-power logic/NVM circuits and efficient photovoltaic energy harvester. Threshold voltage engineering and driving current boosting technologies enable stackable Ge/Si UTB (<;15nm) MOSFETs, CMOS inverter and SRAM (SNM=270mV@0.7V) achieve low operation voltage. Stackable 1-T NVM with high speed (100ns) and low driving-voltage operation provide power-off storage while SRAM serve as power-on working memory. 100% aperture ratio SiGeC ambient light energy harvester with maximum output power of 7mW/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> layered on the monolithic 3D-IC chip envisions a self-powered monolithic 3D-IC technology for advanced low-power wire-less sensor networks, wearable devices, and devices for Internet of Things.
Jenaneane D. Fowler, Thephoric Personal Names in Ancient Hebrew. A Comparative Study, (Journal for the Study of the Old Testament Supplement Series n°49) (1995)

Israel Felice. Jenaneane D. Fowler, Thephoric Personal Names in Ancient Hebrew. A Comparative Study, (Journal for the Study of the Old Testament Supplement Series n°49). In: Syria. Tome 72 fascicule 3-4, 1995. pp. 449-450.
Risk factors of pancreatic fistula after 125I particles implantation for advanced pancreatic carcinoma (2014)

Objective To explore the correlated risk factors of pancreatic fistula after 125I radioactive particles implantation for advanced pancreatic carcinoma.Methods Using pre-determined inclusion and exclusion criteria,we retrospectively studied the clinical data of 55 patients with advanced pancreatic carcinoma who underwent 125I radioactive particles implantation from January 2009 to June 2014.We divided these patients into two groups:the pancreatic fistula group and the non-pancreatic fistula group.We carried out single factor analysis on age,sex,preoperative serum total bilirubin,preoperative serum albumin,diabe-tes,operation time,volume of intro-operative bleeding,size of tumor,implant position,number of particles,postoperative serum albumin and drugs which inhibited secretion of pancreatic juice respectively.If two or more factors showed significant differences between the two groups,we did further Logistic regression analysis of the multifactors.Results There was no peri-operation death in the 55 patients who received 125I radioactive particles implantation.Pancreatic fistula occurred in 9 patients (16.4％).On single factor analysis,there was no correlation in postoperative pancreatic fistula between the two groups in the factors for age,sex,preoperative serum total bilirubin,diabetes,number of particles,operation time,peri-operative serum albumin (P ＞ 0.05).However,the factors of implant position and drugs that inhibited the secretion of pancreatic juice were significantly related to postoperative pancreatic fistula (P ＜ 0.05).On multifactor analysis,the implant position and drugs which inhibited the secretion of pancreatic juice were risk factors of postoperative pancreatic fistula.Conclusions 125I radioactive particles implantation was safe and efficacious for patients with advanced pancreatic carcinoma.Tumors located in the head or neck or uncinate process of pancreas,and drugs that inhibited secretion of pancreatic juice (somatostatin or octreotide acetate) significantly reduced the incidence of pancreatic fistula after operation.

Key words: 
Pancreatic cancer;  Radiotherapy;  Iodine-125 seeds;  Complication;  Pancreatic fistula
Assessment of Cardiovascular Apoptosis in the Isolated Rat Heart by Magnetic Resonance Molecular Imaging (2006)

Apoptosis, an active process of cell self-destruction, is associated with myocardial ischemia. The redistribution of phosphatidylserine (PS) from the inner to the outer leaflet of the cell membrane is an early event in apoptosis. Annexin V, a protein with high specificity and tight binding to PS, was used to identify and localize apoptosis in the ischemic heart.Fluorescein-labeled annexin V has been used routinely for the assessment of apoptosis in vitro. For the detection of apoptosis in vivo, positron emission tomography and single-photon emission computed tomography have been shown to be suitable tools. In view of the relatively low spatial resolution of nuclear imaging techniques, we developed a high-resolution contrast-enhanced magnetic resonance imaging (MRI) method that allows rapid and noninvasive monitoring of apoptosis in intact organs. Instead of employing superparamagnetic iron oxide particles linked to annexin V, a new T1 contrast agent was used. To this effect, annexin V was linked to gadolinium diethylenetriamine pentaacetate (Gd-DTPA)-coated liposomes. The left coronary artery of perfused isolated rat hearts was ligated for 30 min followed by reperfusion. T(1) and T(2)* images were acquired by using an 11.7-T magnet before and after intracoronary injection of Gd-DTP-labeled annexin V to visualize apoptotic cells. A significant increase in signal intensity was visible in those regions containing cardiomyocytes in the early stage of apoptosis. Because labeling of early apoptotic cell death in intact organs by histological and immunohistochemical methods remains challenging, the use of Gd-DTPA-labeled annexin V in MRI is clearly an improvement in rapid targeting of apoptotic cells in the ischemic and reperfused myocardium.
Sorption kinetics of hydrophobic organic compounds to natural sediments and soils (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSorption kinetics of hydrophobic organic compounds to natural sediments and soilsShian Chee. Wu and Philip M. GschwendCite this: Environ. Sci. Technol. 1986, 20, 7, 717–725Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://doi.org/10.1021/es00149a011RIGHTS & PERMISSIONSArticle Views1618Altmetric-Citations468LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts Get e-Alerts
Longterm Followup Assessment of a HER2/ neu Peptide (E75) Vaccine for Prevention of Recurrence in High-Risk Prostate Cancer Patients (2009)

The HER2/neu (E75) vaccine can prevent or delay recurrences in HRPC patients if completed before PSA recurrence. A larger randomized phase II trial in HLA-A2(+) patients will be required to confirm these findings.
Evaluation of the Effect of Low Salinity Waterflooding for 26 Fields in Wyoming (2011)

Abstract This report evaluates the effectiveness of low-salinity waterflooding in the Minnelusa Formation in the Powder River Basin of Wyoming. The Minnelusa sandstone play constitutes a resource of over one-hundred fields with cumulative production of more than 600,000,000 barrels of oil. We conducted initial laboratory screening using Minnelusa oil and rock with synthetic brine, supplemented with geochemical models of low-salinity injection, to evaluate the potential for low-salinity waterflooding in this formation. The laboratory experiments showed little or no incremental recovery from low-salinity injection. Calculation and comparison of recovery factors for 51 Minnelusa reservoirs were used to further evaluate the effectiveness of low-salinity waterfloods at the field scale. There was no increase in recovery for fields that used low salinity injection (26) compared to fields with mixed or formation water injection (25). Since some Minnelusa fields have relatively fresh formation water, the amount of dilution was quantified using the salinity ratio (SR), defined as the ratio of salinity of injected water to salinity of formation water. This analysis showed that while some fields actually had little or any salinity reduction (13), the remaining fields with significant dilution (38) still showed no correlation between dilution and recovery factor. Since some postulated mechanisms involve change in wettability, injection of low-salinity water may produce later water breakthrough. Analysis of water breakthrough timing and watercut evolution for 23 fields found no significant difference between fields with low-salinity injection and mixed-water or saline injection.
Synthesis of Novel Bis(β‐enaminoketonato)titanium Catalyst with High Activity and Excellent Ability to Copolymerize Olefins (2012)

Abstract A new titanium complex [PhN=C(Ph)CHC(CF 3 )O] 2 TiCl 2 (2a), with an asymmetric β‐enaminoketonato [N,O] ligand, has been synthesized and fully characterized. With modified methylaluminoxane as a cocatalyst, the behaviors of ethylene polymerization, and ethylene/α‐olefin and ethylene/norbornene copolymerization have been explored in detail. Relative to its regioisomer 2b ([PhN=C(CF 3 )CHC(Ph)O] 2 TiCl 2 ), the present catalyst exhibits significant predominance. The catalytic activity in 2a‐catalyzed homo‐ and copolymerization are much higher than those in 2b‐catalyzed (co)polymerization. Furthermore, compared with 2b, catalyst 2a possesses an obviously stronger ability towards copolymerization, due to a wide coordination space caused by exchanging the position of the phenyl group and trifluoromethyl group on the framework.