gebhart/patrepeval huggingface dataset:
Jerarquización de una cartera de clientes mediante redes neuronales artificiales (2001)

La evolucion de la organizacion de los sistemas de informacion, los avances que se han producido desde el punto de vista tecnico junto con la gran cantidad de informacion que las La evolucion de la organizacion de los sistemas de informacion, organizaciones manejan de poblaciones muy numerosas conducen a una mayor utilizacion de tecnicas denominadas de mineria de datos. Dentro de estas tecnicas las redes neuronales artificiales tienen una especial relevancia por las potencialidades de utilizacion. Operando con las especificaciones (unidades de procesamiento, numero de capas, funcion de transferencia, regla de aprendizaje, etc.) resultan interesantes para la aplicacion en investigacion de mercados y en marketing. En este trabajo se presenta una aplicacion a la jerarquizacion de una cartera de clientes como ayuda para la accion en promocion u otras variables de marketing-mix.
New Prenylflavones from the Leaves of <i>Epimedium sagittatum</i> (1996)

Five new prenylflavones, yinyanghuo A (1), yinyanghuo B (2), yinyanghuo C (3), yinyanghuo D (4), and yinyanghuo E (5), along with six known flavonoids, chrysoeriol, quercetin, apigenin, apigenin 7,4'-dimethyl ether, kaempferol, and luteolin, were isolated from the leaves of Epimedium sagittatum. Their structures were determined from spectral analysis. Compounds 1 and 2 showed significant antiplatelet induced by arachidonic acid.
Optical polarisation control utilising an optical heterodyne detection scheme (1985)

An optical polarisation control scheme utilising optical heterodyne detection for coherent transmission is proposed and demonstrated at a wavelength of 1.5 μm. It converts an arbitrary polarisation state to a linear state at a received optical power level of less than −70 dBm.
Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and In Vitro Efficacy Analysis (2017)

JAA-F11 is a highly specific mouse monoclonal to the Thomsen-Friedenreich Antigen (TF-Ag) which is an alpha-O-linked disaccharide antigen on the surface of ~80% of human carcinomas, including breast, lung, colon, bladder, ovarian, and prostate cancers, and is cryptic on normal cells. JAA-F11 has potential, when humanized, for cancer immunotherapy for multiple cancer types. Humanization of JAA-F11, was performed utilizing complementarity determining regions grafting on a homology framework. The objective herein is to test the specificity, affinity and biology efficacy of the humanized JAA-F11 (hJAA-F11). Using a 609 target glycan array, 2 hJAA-F11 constructs were shown to have excellent chemical specificity, binding only to TF-Ag alpha-linked structures and not to TF-Ag beta-linked structures. The relative affinity of these hJAA-F11 constructs for TF-Ag was improved over the mouse antibody, while T20 scoring predicted low clinical immunogenicity. The hJAA-F11 constructs produced antibody-dependent cellular cytotoxicity in breast and lung tumor lines shown to express TF-Ag by flow cytometry. Internalization of hJAA-F11 into cancer cells was also shown using a surface binding ELISA and confirmed by immunofluorescence microscopy. Both the naked hJAA-F11 and a maytansine-conjugated antibody (hJAA-F11-DM1) suppressed in vivo tumor progression in a human breast cancer xenograft model in SCID mice. Together, our results support the conclusion that the humanized antibody to the TF-Ag has potential as an adjunct therapy, either directly or as part of an antibody drug conjugate, to treat breast cancer, including triple negative breast cancer which currently has no targeted therapy, as well as lung cancer.
Increased serum level of vascular endothelial growth factor in <i>Mycobacterium avium</i> complex infection (2006)

This study suggests that VEGF may be associated with the pathogenesis of pulmonary MAC infection. Additionally, serum VEGF levels may be a useful surrogate marker for evaluating the extent of disease and of the response to treatment.
Persistent Parasitemia after Acute Babesiosis (1998)

When left untreated, silent babesial infection may persist for months or even years. Although treatment with clindamycin and quinine reduces the duration of parasitemia, infection may still persist and recrudesce and side effects are common. Improved treatments are needed.
Comments on a Secret-Key-Privacy-Preserving Authentication and Key Agreement Scheme (2011)

Lots applications need involved parties to share common session keys for specific requirements. For example, the shared key can be the seed to determine locations to hide secret data into an image. Wang et al. proposed an authentication scheme with key agreement based on the elliptic curve discrete logarithm problem in 2011. They claimed that their scheme had seven advantages. (1) A verification table is not required in the server. (2) The client's password can be changed easily, and the server cannot obtain the client's password. (3) Their scheme could resist all well-known security threats. (4) No time synchronization is needed. (5)The client and the server can share a common session key. (6) Their scheme is efficient and practical. (7) Their scheme can protect the privacy of the client's secret information. After we analyze Wang et al.'s scheme thoroughly, we find that their scheme suffers from three threats. In this paper, we will show the perceived security threats of Wang et al.'s scheme in detail.
High-Molecular-Weight, High-Unsaturation Copolymers of Isobutylene and Conjugated Dienes. I. Synthesis (1976)

Abstract This investigation has provided insight into the critical role of solution properties on the course of cationic polymerization and has led to a technique for reconciling the opposing demands for synthesis of isoolefin-diene copolymers both free from gel and high in molecular weight. By this technique, the synthesis of a broad range of intermediate-unsaturation elastomers of quality has been realized.
Water-Saving Technology and Efficient Tariffs (2010)

Dynamic model of efficient allocation of water with three sources of water supply (groundwater, surface water and the recycling technology with limited capacity) is constructed and analyzed. It is shown that in case of binding capacity constraint we can abandon the use of groundwater at some moment and then revert to it some time in future. Efficient path could be decentralized under suitable water tariffs. Comparative analyses of water tariffs for the two users that differ only in terms of the availability of recycling technology are undertaken.
Collision avoidance of moving obstacles for ship with genetic algorithm (2000)

By use of a path planning method-genetic algorithms (GA), collisions with navigation obstacles and other moving ships can be avoided according to navigation traffic rule (the ship must pass on the right). Navigation obstacles and moving ships are identified by automatic radar plotting aids (ARPA), and then the future danger which is generated by the obstacles is predicted using a stochastic predictor. The stochastic predictor is designed such that the probability density map of the obstacle existence is predicted based on a Markov process model in enough future time. Evaluation of collision danger and efficiency of a path is taken in a cost function of GA. A safe and optimal path is given by this method. In heavy navigation traffic areas, correct selection of ship's speed, when accompanied by necessary path changes, is a crucial element in the safe navigation too. So the speed of own ship is introduced to the cost function of GA, and is modified along environment of navigation and the value of the cost function. The control method is confirmed by an experimental system that is the "Shioji Maru", which is the training ship of Tokyo University of Mercantile Marine. The experimental results are presented.
Synthesis of 7-ethoxy- and 7-fluoro-phenothiazines (2003)

Synthesis of 7-ethoxy- and 7-fluoro-phenothiazines is reported by Smiles rearrangement of 5-ethoxy- and 5-fluoro-2-formamido-2′-nitrodiphenylsulfides. The later were obtained by the formylation of 2-amino-5-ethoxy/5-fluoro-2′-nitrodiphenylsulfides which were prepared by the condensation of 2-amino-5-ethoxy/5-fluoro-benzenethiols with o-halonitrobenzenes.
A Rate Study of the Silanol Condensation Reaction at 25° in Alcoholic Solvents<sup>1</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Rate Study of the Silanol Condensation Reaction at 25° in Alcoholic Solvents1W. T. GrubbCite this: J. Am. Chem. Soc. 1954, 76, 13, 3408–3414Publication Date (Print):July 1, 1954Publication History Published online1 May 2002Published inissue 1 July 1954https://pubs.acs.org/doi/10.1021/ja01642a014https://doi.org/10.1021/ja01642a014research-articleACS PublicationsRequest reuse permissionsArticle Views1550Altmetric-Citations109LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An inland record of the Pacific baza at Tibooburra, far north-western New South Wales (2007)

This note details an immature Pacific Baza Aviceda subcristata observed at Tibooburra, in north-western New South Wales, in July 2005. This bird was in atypically arid habitat 700 km west of the nearest likely breeding population in southern Queensland.
Some Methodological Remarks on Generative Grammar (1961)

(1961). Some Methodological Remarks on Generative Grammar. WORD: Vol. 17, No. 2, pp. 219-239.
Testosterone for schizophrenia (2007)

Results are inconclusive with most outcomes being either non-significant or producing contradictory findings. Currently, adjunctive DHEA should remain an experimental treatment for people with schizophrenia.
Quantitative transient GUS expression in J-104 rice calli through manipulation of in vitro culture conditions. (2009)

Expresión transitoria GUS en callos de arroz (var. J-104) mediante la optimización de las condiciones de cultivo in vitro Resumen This paper purposes suitable conditions for callus induction and co-cultivation with Agrobacterium tumefaciens of J-104 rice cultivar. It was evaluated the effect of different concentrations of 2.4-D and agar, and the inclusion of L-proline and L-glutamine in callus culture medium. The use of 2.5 mg/L 2.4-D and 0.8% agar allowed the highest percentage of embryogenic calli. Callus formation was improved considerably with 500 mg/L of L-proline and L-glutamine in the culture medium. Different factors were studied throughout co-cultivation of calli with A. tumefaciens: inoculation time, co-cultivation temperature, concentration of acetosyringone and co-cultivation period. Transient GUS expression was quantified by fluorometry in all co-cultivated calli. The best results were obtained with the following conditions: 10 min as inoculation time, 100µM acetosyringone in co-cultivation medium, temperature of 20ºC, and 3 days as co-cultivation period. Key words: Agar; callus; co-cultivation; fluorometric GUS activity. Resumen Se describen las condiciones óptimas para la callogénesis y cocultivo de callos con Agrobacterium tume-faciens de la variedad de arroz J-104. Se determinó el efecto de diferentes concentraciones de 2.4-D, agar y de L-prolina y L-glutamina en el medio de cultivo de callos. El uso de 2,5 mg/L de 2.4-D y 0,8% de agar permitió lograr el porcentaje más alto de callos embriogénicos. La formación de callos fue mejorada considerablemente con la adición de 500 mg/L de L-prolina e igual concentración de L-glutamina en el medio de cultivo. Se estudiaron diferentes factores en el cocultivo de los callos con A. tumefaciens: tiempo de inoculación, concentración de acetosiringona, temperatura y tiempo de cocultivo. Para comparar el efecto de cada factor sobre la expresión GUS se cuantificó la actividad transitoria mediante fluorimetría. Los valores más altos de actividad fluorimétrica fueron obtenidos con las siguientes condiciones: 10 min de inoculación, 100µM de acetosiringona en el medio de cocultivo y 3 días de cocultivo a 20 ºC. Palabras clave: agar; callo; cocultivo; actividad fluorimétrica GUS.
Host Determinants of <i>Helicobacter pylori</i> Infection and Its Clinical Outcome (1999)

Greater than one-half of the world's population harbors Helicobacter pylori. The majority of infected individuals, however, remain asymptomatic, with only 10% to 20% developing diseases, including peptic ulcer disease, gastric cancer, and gastric mucosa-associated lymphoid tissue lymphoma. This article reviews host factors that may predispose an individual to both the acquisition of H. pylori infection and subsequent clinical outcome. Individuals with specific blood group antigens and human leukocyte antigen genotypes may be more susceptible to H. pylori infection. Additional factors, such as the age of acquisition, the host immune response, the site of infection, acid secretion, and interactions with nonhost factors (including bacterial virulence factors and environmental influences) may play a role in determining clinical outcome. Further investigation is required to clarify the mechanisms by which these interactions occur and, more critically, to determine their relative importance. This knowledge will enable the identification of individuals at risk of developing clinical disease with H. pylori infection.
Enhancement of Insulin-Like Growth Factor Signaling in Human Breast Cancer: Estrogen Regulation of Insulin Receptor Substrate-1 Expression in Vitro and in Vivo (1999)

Cross-talk between insulin-like growth factor (IGF)- and estrogen receptor (ER)-signaling pathways results in synergistic growth. We show here that estrogen enhances IGF signaling by inducing expression of three key IGF-regulatory molecules, the type 1 IGF receptor (IGFR1) and its downstream signaling molecules, insulin receptor substrate (IRS)-1 and IRS-2. Estrogen induction of IGFR1 and IRS expression resulted in enhanced tyrosine phosphorylation of IRS-1 after IGF-I stimulation, followed by enhanced mitogen-activated protein kinase activation. To examine whether these pathways were similarly activated in vivo, we examined MCF-7 cells grown as xenografts in athymic mice. IRS-1 was expressed at high levels in estrogen-dependent growth of MCF-7 xenografts, but withdrawal of estrogen, which decreased tumor growth, resulted in a dramatic decrease in IRS-1 expression. Finally, we have shown that high IRS-1 expression is an indicator of early disease recurrence in ER-positive human primary breast tumors. Taken together, these data not only reinforce the concept of cross-talk between IGF- and ER-signaling pathways, but indicate that IGF molecules may be critical regulators of estrogen-mediated growth and breast cancer pathogenesis.
High-temperature fracture of composite materials (1990)

The high-temperature fracture of composite materials containing strong particles is discussed on the basis of micromechanical models in which the recovery effect by diffusion of atoms is taken into account. The results of the calculations are compared with experimental results on 21Cr-4Ni-9Mn steels which consist of equiaxed grains containing rod-like M23 C6 carbide particles. The internal stresses acting in the particles and the grains are calculated on the basis of the model. The fracture mode of the material changes from transgranular to grain boundary fracture with increasing temperature, and the elongation of the material increases as a result. These experimental observations can be interpreted in terms of the calculation results of the constant stress model in which non-uniform distribution of plastic strain is assumed, but the calculated results of the constant strain model cannot explain the experimental results.
Melatonin reduces nitric oxide level during ischemia but not blood–brain barrier breakdown during reperfusion in a rat middle cerebral artery occlusion stroke model (2003)

Melatonin is a potent antioxidant and free radical scavenger. Previously, we showed that a single injection of melatonin before ischemia significantly reduced the infarct volume in both permanent and 3-hr middle cerebral artery occlusion (MCAO) rat stroke models. Nitric oxide (NO) and other free radicals play an important role in the pathogenesis of cerebral ischemia, and they have been postulated to mediate the breakdown of the blood-brain barrier (BBB) during ischemia. In this study, we evaluated the influence of melatonin, given at 30 min before MCAO, on brain NO concentration and BBB breakdown. Brain NO concentration was measured at 15 min of MCAO using electron paramagnetic resonance spectroscopy. BBB breakdown at 3 hr of reperfusion following 3 hr of MCAO was assessed using Evans blue extravasation. The relative brain NO concentration was increased to 141.69 +/- 9.71% (mean +/- S.E.M.; n = 9) at 15 min of MCAO. Treatment with melatonin at 1.5, 5, or 50 mg/kg significantly reduced the brain NO concentration to 104.20 +/- 11.20% (n = 8), 55.67 +/- 5.58% (n = 11), and 104.86 +/- 12.56% (n = 9), respectively. Melatonin at 5 mg/kg did not affect Evans blue extravasation. Our results suggest that a single injection of melatonin protects against focal cerebral ischemia partly via inhibition of ischemia-induced NO production and that this regimen does not prevent BBB breakdown following ischemia-reperfusion.
Ontology-guided knowledge discovery in databases (2001)

We present work in progress on a new methodology for leveraging the semantic content of ontologies to guide knowledge discovery in databases. Our system scans new databases to obtain type and constraint information, which users verify. Our system then uses this information in the context of a shared ontology to intelligently guide the potentially combinatorial process of feature construction. Further, our system learns each time it is applied, easing the user's verification task on subsequent runs..
Redefining the Coordination Geometry and Reactivity of Guanidinate Complexes by Covalently Linking the Guanidinate Ligands. Synthesis and Reactivity of [RN{NH(R)}CN(CH<sub>2</sub>)<sub>2</sub>NC{NH(R)}NR]M(CH<sub>2</sub>Ph)<sub>2</sub> (R = <sup>i</sup>Pr; M = Ti, Zr) (2003)

Reaction of the new biguanidine (iPr)HN{NH(iPr)}CN(CH2)2NC{NH(iPr)}N(iPr)H (1) with M(CH2Ph)4 affords the hydrocarbyl complexes [iPrN{NH(iPr)}CN(CH2)2NC{NH(iPr)}NiPr]M(CH2Ph)2 ([L4Pr]M(CH2Ph)4; M = Ti (2), Zr (3)). Structure determinations of 2 and 3 and the reactivity of 3 with 2,6-dimethylphenyl isocyanide indicate that the linked guanidinate ligand system provides a more open metal coordination sphere than do the unlinked analogues.
40GHz Up-conversion in Radio-over-fiber System Using a 10GHz Modulator and Birefringent Fiber Loop (2006)

A novel up-conversion scheme is proposed and demonstrated experimentally for 2.5 Gbit/s ROF system by using a 10 GHz modulator and birefringent fiber loop. The up-conversion signals carried by 40 GHz CSRZ optical pulse are obtained
Epithelial-mesenchymal transition in EGFR-TKI acquired resistant lung adenocarcinoma. (2010)

EMT plays a role in approximately half of the cases of resistance to EGFR-TKI, independent of T790M mutation.
Poly(2,5‐dialkoxy‐<i>p</i>‐phenylene)s—synthesis and properties (1994)

Abstract The synthesis of poly(2,5‐dialkoxy‐ p ‐phenylene)s (PPP) by palladium‐catalyzed polycondensation of 2,5‐dialkoxy‐4‐bromophenylboronic acids is described. Number‐average degrees of polymerization of ca. 30 have been reached at best. The characterization of the polymers by NMR, IR, UV‐VIS and fluorescence spectra, data on the bulk structure obtained by X‐ray methods, melting behavior and thermal stability are reported. PPP's with long alkoxy side chains exhibit a layered phase structure, those with short or branched alkoxy side chains, cylindrical packing. Poly(2,5‐dibutoxy‐ p ‐phenylene) was prepared with chain lengths 7 ≤ P n ≤ 30. The polymer with P n of 30 shows thermal transitions in the bulk phase at 182°C and 227°C. It forms an anisotropic melt above 227°C which only starts decomposing if heated above 300°C. The polymers of shorter chain length show isotropic melts, with the melting point strongly depending on chain length.
Kinetics of the pyrolysis of trimethylarsine, tristrifluoromethylarsine, and related compounds (1954)

P. B. Ayscough and H. J. Emeléus, J. Chem. Soc., 1954, 3381 DOI: 10.1039/JR9540003381
Palladium‐Catalyzed Suzuki–Miyaura, Heck and Hydroarylation Reactions on (–)‐Levoglucosenone and Application to the Synthesis of Chiral γ‐Butyrolactones (2015)

Abstract The chiral pool material (–)‐levoglucosenone (6,8‐dioxabicyclo[3.2.1]oct‐2‐en‐4‐one, LGO) has been substituted by using a series of Pd‐mediated cross‐coupling reactions. Iodination of LGO followed by Suzuki–Miyaura cross‐coupling reaction with boronic acids by employing the Buchwald ligand SPhos with Pd(OAc) 2 afforded 3‐aryl derivatives in excellent yields. Selective Heck arylation reaction at the 2‐position was achieved with aryl iodides with K 3 PO 4 as base and SPhos ligand with Pd(OAc) 2 (1–5 mol‐%). A selective hydroarylation reaction (formal conjugate addition) was developed by using the same aryl iodides, benzyldiethylamine, Pd(OAc) 2 , and P( o ‐tol) 3 . The products were converted, either directly or after alkene reduction, through a Baeyer–Villiger oxidation into chiral 3‐ and 4‐substituted 5‐(hydroxymethyl)dihydrofuran‐2(3 H )‐ones.
Membrane sialic acid on target particles modulates their phagocytosis by a trypsin-sensitive mechanism on human monocytes. (1978)

Monolayers of human peripheral blood monocytes in the absence of exogenous proteins ingest a variety of natural particulate activators of the human alternative complement pathway. Sheep erythrocytes, which do not ordinarily activate the human alternative complement pathway or initiate a direct monocyte phagocytic response, can be modified to exhibit both functions by the deletion or alteration of membrane sialic acid residues. Enzymatic removal of the sialic acid residues with sialidase or their conversion to heptulosonic acid derivatives by limited oxidation with NaIO4 and reduction with BH4- have equivalent dose-response effects on the capacity of the altered sheep erythrocytes to initiate the phagocytic response by human monocytes or to activate the alternative pathway in human serum. The deposition of C3b on native sheep erythrocytes had little effect on their ingestion by human monocytes, whereas the fixation of C3b on desialated sheep erythrocytes had a synergistic effect on the percentage of monocytes ingesting such a particle. The monocyte receptor essential for ingestion of desialated sheep erythrocytes or desialated sheep erythrocytes bearing C3b was inactivated by concentrations of trypsin that also prevented the monocytes from ingesting natural activators of the human alternative complement pathway, but did not alter the receptors for C3b or the Fc portion of IgG. The capacity of the nonimmune host to respond to desialated particles by initiating the monocyte ingestive process and by activating the alternative complement pathway to provide the synergy afforded by C3b deposition on that particle represents a primitive biochemical basis for differentiation of nonself from self.