gebhart/patrepeval huggingface dataset:
Tin- and indium-mediated allylation in aqueous media: application to unprotected carbohydrates (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTin- and indium-mediated allylation in aqueous media: application to unprotected carbohydratesEnoch Kim, Dana M. Gordon, Walther Schmid, and George M. WhitesidesCite this: J. Org. Chem. 1993, 58, 20, 5500–5507Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/jo00072a038https://doi.org/10.1021/jo00072a038research-articleACS PublicationsRequest reuse permissionsArticle Views1325Altmetric-Citations168LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Large-scale detection of non-technical losses in imbalanced data sets (2016)

Non-technical losses (NTL) such as electricity theft cause significant harm to our economies, as in some countries they may range up to 40% of the total electricity distributed. Detecting NTLs requires costly on-site inspections. Accurate prediction of NTLs for customers using machine learning is therefore crucial. To date, related research largely ignore that the two classes of regular and non-regular customers are highly imbalanced, that NTL proportions may change and mostly consider small data sets, often not allowing to deploy the results in production. In this paper, we present a comprehensive approach to assess three NTL detection models for different NTL proportions in large real world data sets of 100Ks of customers: Boolean rules, fuzzy logic and Support Vector Machine. This work has resulted in appreciable results that are about to be deployed in a leading industry solution. We believe that the considerations and observations made in this contribution are necessary for future smart meter research in order to report their effectiveness on imbalanced and large real world data sets.
Synthesis of 2-substituted 2′-deoxyguanosines and 6-O-allylguanines via the activation of C-2 by a trifluoromethanesulfonate group (1997)

A new general synthesis of 2-substituted 2′-deoxyguanosine and 6-O-allylguanine analogues is reported. 2-O-Trifluoromethylsulfonyl-6-O-allyl-3′,5 ′-bis-O-(tert-butyldimethylsilyl)-2′- deoxyxanthosine 8 can be converted into a 2-substituted 2′-deoxyguanosine analogue by substitution of the triflate (trifluoromethanesulfonate) moiety using a selected nucleophile, followed by deprotection. Therefore, a 2′-deoxyguanosine may overall be converted into a 2-substituted 2′-hypoxanthosine analogue in seven steps. Similar methodology has been used to synthesize 2-substituted 6-O-allylguanines which are of particular interest as potential resistance-modifying agents in cancer chemotherapy.
Survey on Machine Learning based scheduling in Cloud Computing (2017)

In the modern era, cloud computing gains a lot of attention due to its various features such as it is simple to use, minimum cost, and mostly low power consumption. Many algorithms and techniques have been proposed for scheduling of virtual machines to provide dynamic load balancing, dynamic scalability and reallocation of resources. Intelligent algorithms are used for the optimization of results and minimizing the makespan scheduling while utilizing the resources efficiently based on dynamic environment. This paper reviews various intelligent scheduling algorithms such as Genetic Algorithm (GA), Simulated annealing (SA), Tabu Search (TS), Ant Colony Optimization (ACO), Particle Swarm Optimization (PSO), Artificial Immune System (AIS), Bacterial Foraging Algorithm (BF), Fish Swarm Optimization Algorithm (FS), Cat Swarm Optimization Algorithm (CS), Firefly Algorithm (FF), Cuckoo Search Algorithm (CS), Artificial Bee Colony (ABC), Bat Algorithm (BA).
GPS III URA and URRA Information for Optimal User Performance (2003)

The GPS III will provide enhanced accuracy and integrity relative to the current GPS. Timely update of broadcast ephemeris and clock parameters will reduce Age-of-Data (AOD) and ranging error associated with Space Vehicle (SV) orbital and clock state prediction. Up-to-date, reliable statistical accuracy information in the form of broadcast User Range Accuracy (URA) and User Range Rate Accuracy (URRA) would enhance the availability of accuracy and integrity for certain operations. The current GPS AOD varies significantly from SV to SV due to staggered upload operations. The Signal in Space (SIS) User Range Error (URE) can vary significantly over time and between SVs due to differences or changes in AOD, uncertainty in SV dynamics, SV clock behavior, geometry/observability, etc. The current URA Index binning structure definition for civilian signals (defined in ICD-GPS-200C) has insufficient resolution to adequately represent the current and projected decrease in SIS errors. Also, the current URA information is not updated frequently enough for applications that require integrity. New, proposed broadcast URA and URRA (or URAdot) information on the modernized signals would provide greater resolution and more closely correspond to the observed SIS accuracy, which would allow user equipment navigation filters to reliably implement weighted Line-of-Sight (LOS) measurement error processing to optimize PVT solutions. Frequent and timely updates would allow this information to be used for applications that require integrity, such as for calculation of protection levels and enhanced Receiver Autonomous Integrity Monitoring (RAIM) performance. Results are presented which show that global performance is significantly enhanced when user equipment implement the above processing approach (e.g. weighted least squares) where the SIS error weighting is given by the reliable, up-to-date broadcast URA information, having sufficient resolution. Global performance statistics are given for the case of the current SV staggered upload operational methodology, for a three-hour AOD for all SV, and for the limiting case of zero AOD for all SV.
Inhibition of PP2A, but not PP5, mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells (2006)

The microbial toxin okadaic acid (OA) specifically inhibits PPP-type ser/thr protein phosphatases. OA is an established tumor promoter with numerous cellular effects that include p53-mediated cell cycle arrest. In T51B rat liver epithelial cells, a model useful for tumor promotion studies, p53 activation is induced by tumor-promoting (low nanomolar) concentrations of OA. Two phosphatases sensitive to these concentrations of OA, PP2A and protein phosphatase 5 (PP5), have been implicated as negative regulators of p53. In this study we examined the respective roles of these phosphatases in p53 activation in non-neoplastic T51B cells. Increases in p53 activity were deduced from levels of p21 (cip1) and/or the rat orthologue of mdm2, two p53-regulated gene products whose induction was blocked by siRNA-mediated knockdown of p53. As observed with 10 nM OA, both phospho-ser15-p53 levels and p53 activity were increased by 10 microM fostriecin or SV40 small t-antigen. Both of these treatments selectively inhibit PP2A but not PP5. siRNA-mediated knockdown of PP2A, but not PP5, also increased p53 activity. Finally, adenoviral-mediated over-expression of an OA-resistant form of PP5 did not prevent increased phospho-ser15-p53, p53 protein, or p53 activity caused by 10 nM OA. Together these results indicate that PP5 blockade is not responsible for OA-induced p53 activation and G1 arrest in T51B cells. In contrast, specific blockade of PP2A mimics p53-related responses to OA in T51B cells, suggesting that PP2A is the target for this response to OA.
Notch 1 Impairs Osteoblastic Cell Differentiation (2003)

Notch receptors are single pass transmembrane receptors activated by membrane-bound ligands with a role in cell proliferation and differentiation. As Notch 1 and 2 mRNAs are expressed by osteoblasts and induced by cortisol, we postulated that Notch could regulate osteoblastogenesis. We investigated the effects of retroviral vectors directing the constitutive expression of the Notch 1 intracellular domain (NotchIC) in murine ST-2 stromal and in MC3T3 cells. NotchIC overexpression was documented by increased Notch 1 transcripts and activity of the Notch-dependent Hairy Enhancer of Split promoter. In the presence of bone morphogenetic protein-2 (BMP-2), ST-2 cells differentiated toward osteoblasts forming mineralized nodules, and Notch 1 opposed this effect and decreased the expression of osteocalcin, type I collagen, and alkaline phosphatase transcripts and Delta2Delta FosB protein. Further, NotchIC decreased Wnt/beta-catenin signaling. As cells differentiated in the presence of BMP-2, they underwent apoptosis, and Notch opposed this event. In the presence of cortisol, NotchIC induced the formation of mature adipocytes and enhanced the effect of cortisol on adipsin, peroxisome proliferator-activated receptor-gamma2 and CCAAT enhancer binding protein alpha and delta mRNA levels. NotchIC also opposed MC3T3 cell differentiation and the expression of a mature osteoblastic phenotype. In conclusion, NotchIC impairs osteoblast differentiation and enhances adipogenesis in stromal cell cultures.
Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins (1997)

Pertussis toxin (PTX) has been widely used as a reagent to characterize the involvement of heterotrimeric G-proteins in signalling. This toxin catalyses the ADP-ribosylation of specific G-protein alpha subunits of the Gi family, and this modification prevents the occurrence of the receptor-G-protein interaction. This review focuses on the biochemical properties and signalling of those G-proteins historically classified as 'PTX-resistant' due to the inability of the toxin to influence signalling through them. These G-proteins include members of the Gq and G12 families and one Gi family member, i.e. Gz. Signalling pathways controlled by these G-proteins are well characterized only for Gq family members, which activate specific isoforms of phospholipase C, resulting in increases in intracellular calcium and activation of protein kinase C (PKC), among other responses. While members of the G12 family have been implicated in processes that regulate cell growth, and Gz has been shown to inhibit adenylate cyclase, the specific downstream targets to these G-proteins in vivo have not been clearly established. Since two of these proteins, G12 alpha and Gz alpha, are excellent substrates for PKC, there is the potential for cross-talk between their signalling and Gq-dependent processes leading to activation of PKC. In tissues that express these G-proteins, a number of guanine-nucleotide-dependent, PTX-resistant, signalling pathways have been defined for which the G-protein involved has not been identified. This review summarizes these pathways and discusses the evidence both for the participation of specific PTX-resistant G-proteins in them and for the regulation of these processes by PKC.
Regulatory B Cell (B10 Cell) Expansion during <i>Listeria</i> Infection Governs Innate and Cellular Immune Responses in Mice (2012)

Pathogens use numerous methods to subvert host immune responses, including the modulation of host IL-10 production by diverse cell types. However, the B cell sources of IL-10 and their overall influence on innate and cellular immune responses have not been well characterized during infections. Using Listeria as a model pathogen, infection drove the acute expansion of a small subset of regulatory B cells (B10 cells) that potently suppress inflammation and autoimmunity through the production of IL-10. Unexpectedly, spleen bacteria loads were 92-97% lower in B10 cell-deficient CD19(-/-) mice, in mice depleted of mature B cells, and in mice treated with CD22 mAb to preferentially deplete B10 cells before infection. By contrast, the adoptive transfer of wild-type B10 cells reduced bacterial clearance by 38-fold in CD19(-/-) mice through IL-10-dependent pathways. B10 cell depletion using CD22 mAb significantly enhanced macrophage phagocytosis of Listeria and their production of IFN-γ, TNF-α, and NO ex vivo. Accelerated bacteria clearance following B10 cell depletion significantly reduced Ag-specific CD4(+) T cell proliferation and cytokine production, but did not alter CD8(+) T cell responses. B10 cell regulatory function during innate immune responses was nonetheless dependent on cognate interactions with CD4(+) T cells because B10 cells deficient in IL-10, MHC-II, or IL-21R expression did not influence Listeria clearance. Thus, Listeria manipulates immune responses through a strategy of immune evasion that involves the preferential expansion of endogenous B10 cells that regulate the magnitude and duration of both innate and cellular immune responses.
Immune responses to the nonglycosylated ectodomain of respiratory syncytial virus attachment glycoprotein mediate pulmonary eosinophilia in inbred strains of mice with different MHC haplotypes (2003)

Development of subunit vaccines against respiratory syncytial virus (RSV) for naive human infants is hindered by concerns that immunization with the fusion or attachment (G) proteins will elicit polarized Type 2 T cell responses and cause immunopotentiation upon subsequent natural infection. We investigated the regions of G protein responsible for inducing a Type 2 T cell phenotype in inbred mice of different MHC haplotype toward development of vaccines with improved safety. As demonstrated by IL-5-dependent pulmonary eosinophilia after challenge and serum anti-G protein IgG1 to IgG2 ratios, highly purified native G protein sensitized all strains for a Type 2 T cell phenotype. Stimulation of G protein-primed splenocytes with synthetic overlapping peptides indicated that the nonglycosylated ectodomain was primarily responsible. Respectively the recall responses of BALB/c (H2(d)), C57BL/6 (H-2(b)), SJL (H-2(s)), and C3H/HeJ (H-2(k)) mice were directed against epitopes within peptides spanning amino acids 184-198 (pep(184-198)), 168-181 (pep(168-181)) or 171-185 (pep(171-185)), 176-190 (pep(176-190)), and 104-118 (pep(104-118)) or 159-173 (pep(159-173)). Injection of pep(184-198) conjugated to KLH (pep(184-198)-KLH) primed H2(d) [BALB/c, B6.C-H2(d)/bBy], but not H-2(b) [C57Bl/6, C.B10-H2(b)/LiMcd] mice for pulmonary eosinophilia. Sensitization with a peptide-KLH conjugate encompassing amino acids 149-200 (pep(149-200)-KLH) further confirmed that Type 2 T cell responses in BALB/c, C57BL/6 and SJL, but not C3H/HeJ mice were induced by the nonglycosylated ectodomain of G protein. These data are important for design of safe and efficacious subunit and attenuated vaccines for RSV.
Certified Monotonic Neural Networks (2020)

Learning monotonic models with respect to a subset of the inputs is a desirable feature to effectively address the fairness, interpretability, and generalization issues in practice. Existing methods for learning monotonic neural networks either require specifically designed model structures to ensure monotonicity, which can be too restrictive/complicated, or enforce monotonicity by adjusting the learning process, which cannot provably guarantee the learned model is monotonic on selected features. In this work, we propose to certify the monotonicity of the general piece-wise linear neural networks by solving a mixed integer linear programming problem.This provides a new general approach for learning monotonic neural networks with arbitrary model structures. Our method allows us to train neural networks with heuristic monotonicity regularizations, and we can gradually increase the regularization magnitude until the learned network is certified monotonic. Compared to prior works, our approach does not require human-designed constraints on the weight space and also yields more accurate approximation. Empirical studies on various datasets demonstrate the efficiency of our approach over the state-of-the-art methods, such as Deep Lattice Networks.
Vertical-cavity surface-emitting laser chip bonding by surface-tension-driven self-assembly for optoelectronic heterogeneous integration (2015)

Twelve-channel vertical-cavity surface-emitting laser (12-ch VCSEL) chips are heterogeneously self-assembled on Si and glass wafers using water surface tension as a driving force. The VCSEL chips have a high length-to-width aspect ratio, that is, 3 mm long and 0.35 mm wide. The VCSEL chips are precisely self-assembled with alignment accuracies within 2 µm even when they are manually placed on liquid droplets provided on the host substrate. After the self-assembly of the VCSEL chips and the subsequent thermal compression, the chips successfully emit 850 nm light and exhibit no degradation of their current–voltage (I–V) characteristics.
Effect of Mg interlayer on perpendicular magnetic anisotropy of CoFeB films in MgO/Mg/CoFeB/Ta structure (2012)

The effects of Mg metallic interlayer on the magnetic properties of thin CoFeB films in MgO/Mg (tMg)/CoFeB (1.2 nm)/Ta structures were studied in this letter. Our experimental result shows that the CoFeB film exhibits perpendicular magnetic anisotropy (PMA) when the CoFeB and MgO layers are separated by a metallic Mg layer with a maximum thickness of 0.8 nm. The origin of PMA was discussed by considering the preferential transmission of the Δ1 symmetry preserved by the Mg interlayer in crystallized MgO/Mg/CoFeB/Ta. In addition, the thin Mg interlayer also contributes to enhancing the thermal stability and reducing the effective damping constant and coercivity of the CoFeB film.
A Three Axis Magnetometer For use in a Small Satellite (2006)

This paper deals with a construction of a three axis magnetometer for use in a small satellite. It is necessary to know the magnetic field around the satellite for an attitude stabilisation and for propulsion. A minimal weight, size and power consumption are the most critical properties of this construction. The magnetic flux has to be measured in an 8-bit resolution. Two small packages with magnetoriesistive sensors from HONEYWELL are used. One package measures magnetic flux in the axis X and Y, and second in the axis Z. The microcontroller is used for data processing, sensors setup and for communication over central bus. Other units in the satellite are able to read the results of the magnetic field measurement over this bus. The software in the microcontroller has to remove any noise and electrical offsets from the data, improves the immunity to an impulse disturbances and a magnetic offsets caused by other electric circuits in the satellite. Construction of this magnetometer is one part of a large project, whose aim is to build Czech amateur satellite compatible with the CubeSat technology.
STRUCTURE AND FUNCTION OF PHOTOSYSTEMS I AND II (2006)

Oxygenic photosynthesis, the principal converter of sunlight into chemical energy on earth, is catalyzed by four multi-subunit membrane-protein complexes: photosystem I (PSI), photosystem II (PSII), the cytochrome b(6)f complex, and F-ATPase. PSI generates the most negative redox potential in nature and largely determines the global amount of enthalpy in living systems. PSII generates an oxidant whose redox potential is high enough to enable it to oxidize H(2)O, a substrate so abundant that it assures a practically unlimited electron source for life on earth. During the last century, the sophisticated techniques of spectroscopy, molecular genetics, and biochemistry were used to reveal the structure and function of the two photosystems. The new structures of PSI and PSII from cyanobacteria, algae, and plants has shed light not only on the architecture and mechanism of action of these intricate membrane complexes, but also on the evolutionary forces that shaped oxygenic photosynthesis.
A Q-Learning-Based Delay-Aware Routing Algorithm to Extend the Lifetime of Underwater Sensor Networks (2017)

Underwater sensor networks (UWSNs) have become a hot research topic because of their various aquatic applications. As the underwater sensor nodes are powered by built-in batteries which are difficult to replace, extending the network lifetime is a most urgent need. Due to the low and variable transmission speed of sound, the design of reliable routing algorithms for UWSNs is challenging. In this paper, we propose a Q-learning based delay-aware routing (QDAR) algorithm to extend the lifetime of underwater sensor networks. In QDAR, a data collection phase is designed to adapt to the dynamic environment. With the application of the Q-learning technique, QDAR can determine a global optimal next hop rather than a greedy one. We define an action-utility function in which residual energy and propagation delay are both considered for adequate routing decisions. Thus, the QDAR algorithm can extend the network lifetime by uniformly distributing the residual energy and provide lower end-to-end delay. The simulation results show that our protocol can yield nearly the same network lifetime, and can reduce the end-to-end delay by 20-25% compared with a classic lifetime-extended routing protocol (QELAR).
Clinical features and outcome in childhood T-cell leukemia-lymphoma according to stage of thymocyte differentiation: a Pediatric Oncology Group Study (1988)

The immunophenotypes of lymphoblasts from children with newly diagnosed T-cell acute lymphoid leukemia (T-ALL, n = 101) or T-cell non-Hodgkin lymphoma (T-NHL, n = 31) were analyzed to correlate stage of thymocyte differentiation with clinical features and outcome. The 67 boys and 34 girls with T-ALL were 1 month to 18 years old (median, 8 years) with leukocyte counts ranging from 2 to 810 x 10(9)/L (median, 55 x 10(9)/L). Eighteen of these patients were black, and 70 had a mediastinal mass. Twenty-six boys and five girls with a median age of 9 years (range, 1 to 20 years) had T-NHL. Seven of these patients were black, and 24 had a mediastinal mass. The distributions of thymocyte developmental stages (early [CD7+], intermediate [CD1+ and/or CD4+ and/or CD8+], and mature [CD3+]) in cases of T-ALL and T-NHL were significantly different: 34%, 43%, and 23% v 6%, 62%, and 32% (P = .02). A comparison of the patients' clinical features according to the maturational stage of thymocytes failed to disclose significant differences in the majority of characteristics studied. However, patients with mature-stage T-NHL, with or without the addition of subjects with mature-stage T-ALL, were less likely to have a mediastinal mass (P = .02 for both comparisons). Those with intermediate-stage T-cell malignancy (T-ALL and T-NHL combined) were the subgroup most likely to have a mediastinal mass (P = .01). Response to remission induction therapy was significantly worse in the T-ALL subgroup with an early-stage phenotype: a failure rate of 21% v 0% and 6% for the two more differentiated phenotypic subgroups (P = .007). Event-free survival was not affected by thymocyte maturational stage in cases of either T-ALL or T-NHL. Despite evidence of clinical heterogeneity among the maturational stages of T-cell malignancies in children, these developmental subdivisions do not appear to be critical determinants of outcome once remission is achieved. We conclude that such phenotypes need not be included in the stratification plans for clinical trials using common induction treatment.