gebhart/patrepeval huggingface dataset:
Bluetooth indoor localization with multiple neural networks (2010)

Over the last years, many different methods have been proposed for indoor localization and navigation services based on Radio frequency (RF) technology and Radio Signal Strength Indicator (RSSI). The accuracy achieved with such systems is typically low, mainly due to the variability of RSSI values, unsuitable for classic localization methods (e.g. triangulation). In this paper, we propose a novel approach based on multiple neural networks. We demonstrate with experimental results that by training and then activating different neural networks, tailored on the user orientation, high definition accuracy is achievable, allowing indoor navigation with a cost effective Bluetooth (BT) architecture.
Ion Flow Crossing Over a Polyelectrolyte Diode on a Microfluidic Chip (2011)

Key evidences are reported for the rectification mechanism of an aqueous ion diode based on polyelectrolytic plugs on a microfluidic chip by monitoring the ion flow crossing over the junction. The ion flow penetrating the polyelectrolyte junction is visualized by employing a fluorescent chemodosimeter, rhodamine B hydrazide and the pH-dependent dye, carboxy-fluorescein. How hysteresis phenomena, exhibited through the nonlinear behavior of the polyelectrolyte diode, are affected by a variety of parameters (e.g., switching potential, scan rate, and electrolyte concentration) is also investigated. The insights and knowledge from this study provide a crucial foundation for ion control at the iontronic diode in the aqueous phase, leading to more advanced aqueous organic computing devices and more diverse applications for microfluidic logic devices.
Sequences of the mouse N-acetylglucosaminyltransferase V (Mgat5) mRNA and an mRNA expressed by an Mgat5-deficient cell line (2002)

N-acetylglucosaminyltransferase V, encoded by the Mgat5 gene, plays an important regulatory role in the synthesis of complex N-glycans, including the Lewis antigens. The elevated expression of this enzyme is regulated during development and is highly associated with cellular transformation and malignancy. In addition, mammary tumors produced in Mgat5 gene knockout mice show markedly reduced metastases, indicating that it plays an important role in this process. The expression of this transferase is important for normal T cell proliferation and function. The amino acid and mRNA sequences for this protein are very highly conserved among the reported species. We report here the sequence of the mouse Mgat5 mRNA. This sequence is very similar to the other mammalian sequences with 95%, 91%, and 87.8% overall sequence identity to rat, hamster, and human mRNAs, respectively. In addition, we have identified a 63-bp insertion mutation, introducing a premature stop codon in the coding region of the Mgat5 mRNA expressed in a N-acetylglucosaminyltransferase V-deficient cell line, PhaR(2.1).
Synthesis and Antifungal Activity of 1,3,2-Benzodithiazole S-Oxides (1994)

The preparation of 1,3,2-benzodithiazole S-oxide analogs exhibiting in vitro antifungal activity against several strains of Candida is described. For the preparation of derivatives bearing aromatic substituents, a novel electrophilic aromatic thiolation reaction was utilized which produced substituted aromatic 1,2-dithiol intermediates. The reactions of nucleophiles with the parent heterocyclic system have led to an efficient transamidation process which allows for the direct production of these analogs. The S-oxide bond exhibits poor stereochemical stability and has been found to epimerize under ambient conditions. The structure-activity data report that a side chain of greater than 10 carbons effects a loss in activity as does the placement of polar groups in this chain.
Safety and Efficacy of Topically Applied Selected Cutibacterium acnes Strains over Five Weeks in Patients with Acne Vulgaris: An Open-label, Pilot Study (2019)

Imbalance in skin microflora, particularly related to certain Cutibacterium acnes strains, may trigger acne. Application of non-acne-causing strains to the skin may modulate the skin microbiome and thereby lead to a reduction in acne. This pilot study evaluates the safety and efficacy of microbiome modulation on acne-prone skin. The study had 2 phases: active induction (5% benzoyl peroxide gel, 7 days) and interventional C. acnes strains treatment (5 weeks). Patients were randomized to either topical skin formulations PT1 (2 strains of C. acnes Single Locus Sequence Typing [SLST] type C3 and K8, 50% each) or PT2 (4 strains of C. acnes SLST type C3 [55%], K8 [5%], A5 [30%] and F4 [10%]). Safety and efficacy was evaluated in 14 patients (PT1=8/14, PT2=6/14). Skin microbiome composition shifted towards study formulations. No untoward adverse events, visible irritation, or significant flare-up were observed. Non-inflamed lesions and skin pH were reduced. Comedone counts improved clinically with no deterioration in inflammatory lesions.
A balanced hierarchical data structure for multidimensional data with highly efficient dynamic characteristics (1993)

A new multidimensional data structure, multidimensional tree (MD-tree), is proposed. The MD-tree is developed by extending the concept of the B-tree to the multidimensional data, so that the MD-tree is a height balanced tree similar to the B-tree. The theoretical worst-case storage utilization is guaranteed to hold more than 66.7% (2/3) of full capacity. The structure of the MD-tree and the algorithms to perform the insertion, deletion, and spatial searching are described. By the series of simulation tests, the performances of the MD-tree and conventional methods are compared. The results indicate that storage utilization is more than 80% in practice, and that retrieval performance and dynamic characteristics are superior to conventional methods.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Computational and Experimental Studies of UV/Titania Photocatalytic Oxidation of VOCs in Honeycomb Monoliths (1998)

Abstract The use of honeycombs as monolith supports for UV/Titania photocatalysis of volatile organic compounds (VOCs) has been investigated theoretically and experimentally. A theoretical model based on analysis of the UV intensity distribution, transport of gaseous contaminants to the catalyzed surface, and surface photocatalytic destruction has been developed. Both diffuse and specular reflection models have been developed for the UV illumination calculations. The model uses measured intrinsic photocatalytic destruction rates determined in a research reactor which gives the concentration-, humidity-, and UV intensity-dependences of the rates. Model predictions have been compared to measurements in a high-flow, staged monolith, demonstration purifier for several gaseous contaminants of interest. Agreement between modeling and experiment is generally quite good. The sensitivity of purifier efficiency to monolith pore size and illuminated contact time is discussed. The performance obtained with honeycombs is comparable to that with porous foams, but with much reduced weight, pressure drop, and cost. The conclusion of this research is that honeycomb monoliths are attractive for use in practical UV/Titania photocatalytic devices, particularly at very high flow rates where pressure drop is a concern, and for those situations where monolith weight is an important design constraint.
Multistep Prediction of Physiological Tremor for Surgical Robotics Applications (2013)

Accurate canceling of physiological tremor is extremely important in robotics-assisted surgical instruments/procedures. The performance of robotics-based hand-held surgical devices degrades in real time due to the presence of phase delay in sensors (hardware) and filtering (software) processes. Effective tremor compensation requires zero-phase lag in filtering process so that the filtered tremor signal can be used to regenerate an opposing motion in real time. Delay as small as 20 ms degrades the performance of human-machine interference. To overcome this phase delay, we employ multistep prediction in this paper. Combined with the existing tremor estimation methods, the procedure improves the overall accuracy by 60% for tremor estimation compared to single-step prediction methods in the presence of phase delay. Experimental results with developed methods for 1-DOF tremor estimation highlight the improvement.
Delta Modulation Technique for Improving the Sensitivity of Monobit Subsamplers in Radar and Coherent Receiver Applications (2014)

This paper introduces a technique for improving the sensitivity of RF subsamplers in radar and coherent receiver applications. The technique, referred to herein as “delta modulation” (DM), feeds the time-average output of a monobit analog-to-digital converter (ADC) back to the ADC input, but with opposite polarity. Assuming pseudostationary modulation statistics on the sampled RF waveform, the feedback signal corrects for aggregate dc offsets present in the ADC that otherwise degrade ADC sensitivity. Two RF integrated circuits (RFICs) are designed to demonstrate the approach. One uses analog DM to create the feedback signal; the other uses digital DM to achieve the same result. A series of tests validates the designs. The dynamic time-domain response confirms the feedback loop's basic operation. Measured output quantization imbalance, under noise-only input drive, significantly improves with the use of the DM circuit, even for large, deliberately induced dc offsets and wide temperature variation from -55 °C to +85 °C. Examination of the corrected versus uncorrected baseband spectrum under swept input signal-to-noise ratio (SNR) conditions demonstrates the effectiveness of this approach for realistic radar and coherent receiver applications. Two-tone testing shows no impact of the DM technique on ADC linearity.
Numerical simulation of porosity‐free titanium dental castings (1999)

The objective of this research was to analyse, predict and control the porosity in titanium dental castings by the use of numerical simulation. A commercial software package (MAGMASOFT) was used. In the first part of the study, a model casting (two simplified tooth crowns connected by a connector bar) was simulated to analyse shrinkage porosity. Secondly, gas pores were numerically examined by means of a ball specimen with a "snake" sprue. The numerical simulation results were compared with the experimental casting results, which were made on a centrifugal casting machine. The predicted shrinkage levels coincided well with the experimentally determined levels. Based on the above numerical analyses, an optimised running and gating system design for the crown model was proposed. The numerical filling and solidification results of the ball specimen showed that this simulation model could be helpful for the explanation of the experimentally indicated gas pores. It was concluded that shrinkage porosity in titanium dental casting was predictable, and it could be minimised by improving the running and gating system design. Entrapped gas pores can be explained from the simulation results of the mould filling and solidification.
Point Mutations in the<i>abl</i>SH2 Domain Coordinately Impair Phosphotyrosine Binding In Vitro and Transforming Activity In Vivo (1992)

We have constructed a series of point mutations in the highly conserved FLVRES motif of the src homology 2 (SH2) domain of the abl tyrosine kinase. Mutant SH2 domains were expressed in bacteria, and their ability to bind to tyrosine-phosphorylated proteins was examined in vitro. Three mutants were greatly reduced in their ability to bind both phosphotyrosine itself and tyrosine-phosphorylated cellular proteins. All of the mutants that retained activity bound to the same set of tyrosine-phosphorylated proteins as did the wild type, suggesting that binding specificity was unaffected. These results implicate the FLVRES motif in direct binding to phosphotyrosine. When the mutant SH2 domains were inserted into an activated abl kinase and expressed in murine fibroblasts, decreased in vitro phosphotyrosine binding correlated with decreased transforming ability. This finding implies that SH2-phosphotyrosine interactions are involved in transmission of positive growth signals by the nonreceptor tyrosine kinases, most likely via the assembly of multiprotein complexes with other tyrosine-phosphorylated proteins.
Detection of Antiviral Antibodies with Predetermined Specificity Using Synthetic Peptide-beta-Lactamase Conjugates: Application to Antibodies Specific for the preS Region of the Hepatitis B Virus Envelope Proteins (1986)

Amino acid sequences coded for by the preS region of the hepatitis B virus (HBV) envelope gene are present both in HBV and in subviral hepatitis B surface antigen (HBsAg) particles. Consequently, anti-preS-specific antibodies are elicited during the course of HBV infection. Such antibodies are virus-neutralizing. Therefore, it is important to determine whether or not vaccination with HBsAg also induces an anti-preS-specific immune response. We describe here an enzyme-linked immunosorbent assay applicable for the screening of sera from vaccinated individuals for anti-preS antibodies. IgG from serum specimens was adsorbed to staphylococcal Protein A on a superparamagnetic support and subsequently mixed with a synthetic peptide analogue [preS(120-145)] covalently linked to beta-lactamase. The presence of anti-preS in serum specimens resulted in binding of the conjugated beta-lactamase to the magnetic support. The adsorbed enzyme was quantified colorimetrically.
Obstructive Sleep Apnea following Treatment of Head and Neck Cancer (2007)

A growing body of literature is suggesting that there is a link between head and neck cancer treated with radiation therapy and the development of obstructive sleep apnea/ hypopnea syndrome (OSAHS). We describe the case of a 54-year-old man with a history of head and neck cancer whose OSAHS had gone undiagnosed for 3 years. After the diagnosis was made on the basis of sleep study data, we determined that the OSAHS was a long-term complication of cervical radiation therapy that had been delivered to treat the patient's laryngeal squamous cell carcinoma 3 years earlier. We also review the literature regarding the association between head and neck cancer and the development of OSAHS.
STANDARD SCALES FOR CRISPNESS, CRACKLINESS AND CRUNCHINESS IN DRY AND WET FOODS: RELATIONSHIP WITH ACOUSTICAL DETERMINATIONS (2008)

ABSTRACT A trained panel developed rating scales for crispness, crunchiness and crackliness for dry and wet foods based on the auditory perception of selected foods. The newly developed scales were then evaluated by 40 untrained panelists and the sound perception of standard foods was assessed through the analysis of the root mean square (RMS) of the 5‐s audio waveforms and multidimensional scaling (MDS). The RMS was highly correlated to auditory sensory perception of crispness ( r = 0.83 and 0.96), crunchiness ( r = 0.99 and 0.99) and crackliness ( r = 0.88 and 0.96) for dry and wet foods, respectively. MDS technique applied for the 40 untrained panelists was instructive in assessing auditory textural differences of naïve panelists and a useful statistical instrument to graphically validate selected scales. Auditory perception of the selected foods were rated similarly using standard auditory texture scales for crispness, crunchiness and crackliness developed by the trained panel (oral evaluation) and MDS results from the untrained panel (recordings). PRACTICAL APPLICATIONS Crispness, crunchiness and crackliness are not only important and useful descriptors of food texture, but are also desirable textural qualities in many foods. The lack of consistency in the procedures used for the evaluation of crunchy, crispy and crackly in sensory studies often results in confusion when training expert panels. Research will benefit textural studies through an improvement of consistent textural definitions and development of standard scales and evaluation techniques. The crispness, crunchiness and crackliness scales developed and applied in the current study represent a new potential standard frame of reference that may be used for training panelists in texture parameters related to food auditory perception. The scales may be considered illustrations demonstrating full and practical ranges for each texture attribute with regard to analyzing auditory parameters of foods and effective objective tools for assessing panelists in descriptive analysis.
Local Smoothness in terms of Variance: the Adaptive GaussianFilter (2000)

Several techniques, such as adaptive smoothing [9, 10] or anisotropic diusion [4, 5] deal with the task of local smoothing. That is, preserv-ing principal discontinuities and smoothing within regions. Unfortu-nately, these types of iterative techniques have as one of their main drawbacks, the determination of the threshold on the luminance gradi-ent. There is no way to control it easily and researchers often fall into a trial-and-error procedure. In this paper an adaptive Gaussian l-ter that computes directly the local amount of Gaussian smoothing in terms of variance is presented. The local variance, (x; y), is selected, in a scale-space framework, through the minimal description length criterion (MDL). The MDL allows us to estimate the local smoothing in such a way that it respects the main discontinuities. The resulting smoothed image, in location x; y, is the intensity given by the convo-lution of the initial point I 0 (x; y) with its appropriate Gaussian kernel
MR endoscopy: preliminary experience in human trials. (1997)

The authors performed local staging of esophageal and rectal cancer (without pathologic correlation) with use of a nonferromagnetic magnetic resonance (MR) endoscope with a 3-cm-long receive-only coil embedded in its tip in 16 patients (eight with esophageal cancer and eight with anorectal cancer). Results with spin-echo sequences were optimal in all cases [corrected].
Genital ulceration as a risk factor for human immunodeficiency virus infection (1988)

Among 115 heterosexual men who presented with genital ulcers to a sexually transmitted disease clinic in Nairobi, Kenya, the prevalence of serum antibody to HIV was 16.5%. A past history of genital ulcers was reported by 12 (63%) of 19 men with antibody to HIV versus 30 (31%) of 96 without antibody (P = 0.008). HIV infection was also positively associated with lack of circumcision, but was not associated with the etiology of the current genital ulcer. Logistic regression analysis (adjusted for age, number of recent sex partners, recent prostitute contact, circumcision, tribal ethnic identity, past history of urethritis, and current diagnoses) confirmed only the association between prior history of genital ulcer disease and HIV infection; (P = 0.04, odds ratio 2.35, 95% confidence limits, 1.01-5.47). The incidence of genital ulcers, particularly chancroid, is much higher in parts of Africa than in Europe or North America. This may contribute to the increased risk of heterosexual transmission of HIV in Africa. Aggressive control of chancroid and syphilis may offer one very feasible approach to reducing transmission of HIV in this region.
Base catalysis by alkali modified zeolites (1989)

The development, characterization, and catalytic application of a novel zeolite with solid base properties has been completed. From isopropanol decomposition to acetone and propylene, the acid/base properties of various alkali exchanged, faujasite-type zeolites are explored. It is found that upon impregnation of CsNaY with cesium hydroxide or cesium acetate, acetone production (normally attributed to base sites) is promoted by an order of magnitude above the untreated (not impregnated) CsNaY zeolite. Furthermore, selectivity to acetone is above 97% and on a surface area basis, acetone activity is found to be comparable to MgO. Impregnation of CsNaX shows little promotion in acetone activity resulting in acetone activity comparable to the untreated CsNaY zeolite and acetone selectivity at 62%. From numerous characterization studies of the impregnated CsNaY zeolite (many in situ) it appears that a highly dispersed intracrystalline cesium oxide is formed from the decomposition of the occluded salt and is believed to be the active site for acetone formation. Evidence is provided also to indicate the presence of an isopropoxide intermediate which is responsible for the acetone and the minor amounts of propylene formed by the acetate impregnated CsNaY zeolite. The cesium acetate impregnated CsNaY catalyst was tested for activity by the base catalyzed alkylation of toluene, acetone, ethane, and methane with methanol. For toluene alkylation, it is determined that little improvement is gained over previous faujasite-type catalysts. This appears to be a result of the rapid decomposition of formaldehyde, i.e., the alkylating agent derived from the dehydrogenation of methanol. MgO is demonstrated to possess base properties similar to the acetate impregnated CsNaY zeolite, yet MgO is found to be inactive in toluene alkylation. Neither ethane or methane is alkylated at 425°C or 465°C by the acetate impregnated zeolites. Acetone is alkylated slightly to methylvinylketone and methylethylketone at 425°C but the majority of the reacted acetone appears to form aldol condensation products.
Fluorine substitution enhanced photovoltaic performance of a D–A1–D–A2 copolymer (2013)

A new alternating donor-acceptor (D-A1-D-A2) copolymer containing two electron-deficient moieties, isoindigo and quinoxaline, was synthesized. The photovoltaic performance of this polymer could be improved by incorporating fluorine atoms into the quinoxaline units, resulting in an efficiency of 6.32%. This result highlights the attractive promise of D-A1-D-A2 copolymers for high-performance bulk heterojunction solar cells.
Natural history of amyotrophic lateral sclerosis in a database population Validation of a scoring system and a model for survival prediction (1995)

Over 1200 patients with motor neuron disease have been carefully diagnosed, followed, and included in a detailed database delineating characteristics of the disease. Of these patients, 831 were identified as exhibiting typical, sporadic amyotrophic lateral sclerosis (ALS). The progression of the disease in these patients has been followed with our scoring system, and the ALS score was verified as a significant covariate of survival. Age at first symptom, delay from first symptom to entering ALS clinic, and rate of change of respiratory function were also identified as significant covariates of survival. These measures, applied to the Cox proportional hazards model, were used to develop a mathematical model for prediction of survival time in ALS, which proved highly accurate for the 80% of patients at intermediate risk. For those patients, a second model was developed which accurately predicts, after an initial period of observation, the time over which ALS patients will decline a set number of points in total ALS score. Such validation permits initial trials for drug therapies in ALS by comparison of relatively small groups of treated patients to this historical control group, based on the model of predicted time to a particular decrement in total ALS score.