gebhart/patrepeval huggingface dataset:
Effect of skin temperature on multifrequency bioelectrical impedance analysis (1996)

This study assessed the effects of changes in skin temperature on multifrequency bioimpedance analysis (MF-BIA) and on the prediction of body water compartments. Skin temperature (baseline 29.3 +/- 2.1 degrees C) of six healthy adults was raised over 50 min to 35.8 +/- 0.6 degrees C, followed by cooling for 20 min to 26.9 +/- 1.3 degrees C, by using an external heating and cooling blanket. MF-BIA was measured at both distal (conventional) and proximal electrode placements. Both distal and proximal impedance varied inversely with a change in skin temperature across all frequencies (5-500 kHz). The change in proximal impedance per degree centigrade change in skin surface temperature was approximately 60% of distal impedance. The change in measured impedance at 50 kHz erroneously increased predicted total body water (TBW) by 2.6 +/- 0.9 liters (P < 0.001) and underpredicted fat mass by 3.3 +/- 1.3 kg (P < 0.0001). Computer modeling of the MF-BIA data indicated changes in predicted water compartments with temperature modifications; however, the ratio of extracellular water (ECW) to TBW did not significantly change (P < 0.4). This change in impedance was not due to a change in the movement of water of the ECW compartment and thus probably represents a change in cutaneous impedance of the skin. Controlled ambient and skin temperatures should be included in the standardization of BIA measurements. The error in predicted TBW is < 1% within an ambient temperature range of 22.3 to 27.7 degrees C (72.1-81.9 degrees F).
Modeling of an acousto-optic laser beam steering system intended for satellite communication (2001)

High data rate of laser communication systems should be matched by wide operational bandwidth of beam positioning. This could be achieved by the application of nonmechanical beam steering technologies utilizing acousto-optic phenomena. Major components of acousto-optic beam steering systems, a Bragg cell, and a quadrant detector are subjected to comprehensive laboratory testing and characterization as components of a control system. A mathematical and computer simulation model of the entire steering system addressing system dynamics, cross coupling of azimuth and elevation channels, and nonlinearity, and facilitating synthesis of advanced control laws is developed.
Transmission of<i>Anaplasma marginale</i>with adult<i>Boophilus microplus</i>ticks fed as nymphs on calves with different levels of rickettsaemia (1994)

Nine splenectomised calves were infested with dissimilar numbers of adult Boophilus microplus ticks 72 h after collection as engorged nymphs from three non splenectomised calves with different levels of Anaplasma marginale rickettsaemia. Successful transmission of A. marginale appeared to be more dependent on the level of rickettsaemia of the donor calves than on the number of ticks attaching to the splenectomised calves, since infection was transmitted only when the rickettsaemia was 0.3% or greater. Field transmission would thus depend on the rate of tick migration amongst susceptible hosts and the rickettsaemia level of cattle on which the ticks fed previously.
Review : Clinical relevance of calreticulin in systemic lupus erythematosus (1997)

Calreticulin is an abundant intracellular protein which is proposed to have numerous biological functions. However, there is increasing evidence to suggest that calreticulin plays a multifunctional role as an autoantigen present in patients with systemic lupus erythematosus. In this review we detail some of the recent evidence which indicate that calreticulin may play a supportive role in the formation of the autoantigen complex-Ro/SS-A. In addition, several proposed mechanisms of release and surface expression of calreticulin are described in relation to SLE mediated responses to the autoantigen. In particular, the generation of autoantibodies to specific regions of the protein and the ability of calreticulin to interfere with complement mediated inflammatory processes.
Diffractive light attenuators with variable transmission (1998)

Abstract A new application of diffractive optical elements (DOEs) for continuous or multistage adjustment of optical radiation intensity is described. The diffractive attenuators are linear or circular gratings (amplitude or phase) with constant period and diffraction efficiency that varies across the grating. The zero order of diffraction is used as the output and transmitted through the grating without angular deviation. The diffractive attenuators, in distinction to conventional analogues, allow one to change the intensity of the light beam according to predetermined function and have no limitations for power of the regulated light beam. These elements can be used in optical systems as a beam splitter with adjusted splitting coefficient. The experimental results on a circular diffractive attenuator fabricated by direct laser writing on a chromium film are presented. The range of transmission variation was 20 times within a 340° angle of attenuator turn. The possibility to use a phase diffractive attenuator as a light radiation modulator for a powerful technological laser is discussed.
Internal Parallelism of Flash Memory-Based Solid-State Drives (2016)

A unique merit of a solid-state drive (SSD) is its internal parallelism . In this article, we present a set of comprehensive studies on understanding and exploiting internal parallelism of SSDs. Through extensive experiments and thorough analysis, we show that exploiting internal parallelism of SSDs can not only substantially improve input/output (I/O) performance but also may lead to some surprising side effects and dynamics. For example, we find that with parallel I/Os, SSD performance is no longer highly sensitive to access patterns (random or sequential), but rather to other factors, such as data access interferences and physical data layout. Many of our prior understandings about SSDs also need to be reconsidered. For example, we find that with parallel I/Os, write performance could outperform reads and is largely independent of access patterns, which is opposite to our long-existing common understanding about slow random writes on SSDs. We have also observed a strong interference between concurrent reads and writes as well as the impact of physical data layout to parallel I/O performance. Based on these findings, we present a set of case studies in database management systems, a typical data-intensive application. Our case studies show that exploiting internal parallelism is not only the key to enhancing application performance, and more importantly, it also fundamentally changes the equation for optimizing applications. This calls for a careful reconsideration of various aspects in application and system designs. Furthermore, we give a set of experimental studies on new-generation SSDs and the interaction between internal and external parallelism in an SSD-based Redundant Array of Independent Disks (RAID) storage. With these critical findings, we finally make a set of recommendations to system architects and application designers for effectively exploiting internal parallelism.
Modeling the prediction of the Financial Behavior in Iranian Stock Market Investors with an Interpretive Structural Approach (1999)

Nowadays, predicting the financial behavior of investors plays a crucial role in decision-making and the financial policy-making process. This study is aimed at providing a paradigm to predict the financial behavior of investors in Iran’s stock market. 24 experts were interviewed to identify the variables, and 24 variables were identified. The interpretive structural paradigming was carried out using a self-interaction matrix based on the experts’ opinions. The MICMAC analysis has been used to identify the types of the variables. As findings of the study, a five-level paradigm was determined, in which environmental factors and the background of financial behavior on the fifth level were the most influential variables and also arbitrage, bias, and the perceptual mistake were the most impressible variables of the paradigm on the first level. MICMAC analysis of this study suggested that the variable of environmental factors had low dependence and high efficacy. Furthermore, psychological projection, perceptual mistake, arbitrage, and bias are dependent variables with high dependence and low efficacy. Other variables are mediator variables with high dependence and effectiveness.
MicroRNA Signatures of Colonic Polyps on Screening and Histology (2016)

Colorectal cancer and adenoma adjacent to cancer exhibit distinct microRNA (miRNA) alterations in an apparent mucosa-to-adenocarcinoma sequence. The pattern of microRNAs in screen-detected polyps in relation to histologic features and cancer risk has not been investigated. miRNA expression analysis was performed on normal mucosa (NM), hyperplastic polyps (HP), tubular adenomas (TA), tubulovillous adenomas or high-grade dysplasia (TVHG), and serrated polyps [sessile serrated adenoma/polyps (SSA/P) and traditional serrated adenomas (TSA)] in biopsy specimens from 109 patients undergoing screening/surveillance colonoscopy. Generalized linear models were used to identify differentially expressed miRNAs by histologic type and logistic regression to identify miRNA predictors of histopathology. False discovery rate (FDR) was used to control for multiple comparisons. We identified 99 miRNAs differing in at least one of five histopathologic groups (FDR ≤0.05). In a comparison of HPNM versus TVHG, the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -320b (downregulated; FDR P < 0.05). miR-145 and -619 showed high accuracy to discriminate low- from high-risk polyps without serrated histology (TVHG vs. HPNM + TA; CI, 95.6%), whereas miR-124, -143, and -30a showed high accuracy of separating high-risk polyps (TVHG + TSA) from low-risk polyps (HPNM + TA + SSA/P; CI, 96.0%). For TSAs, miR-125b and -199a were uniquely downregulated relative to HPNMs, and miR-335, -222, and -214 discriminated between non-serrated and serrated histology. Our data support the presence of colorectal cancer-associated miRNA alterations in screen-detected adenomas that may be useful for risk stratification for surveillance interval planning. Cancer Prev Res; 9(12); 942-9. ©2016 AACR.
Microbial Resolution of (±)-Acyclic Alcohols (1973)

By selected microorganisms the acetates of the racemic sec-alcohols were asymmetrically hydrolyzed to optically active sec-alcohols and the acetates of their antipodes. Microbial hydrolysis of the acetates of the racemic prim-alcohols having an asymmetrical carbon atom at the β-position gave lower optically active alcohols and the acetates of their antipodes, but the acetates having an asymmetrical carbon atom at the γ-position were hydrolyzed only to give racemic alcohols.
Urinary Tract Infections in Young Adult Women Caused by Staphylococcus saprophyticus (1983)

We evaluated and compared 81 urinary tract infections (UTIs) with Staphylococcus saprophyticus occurring in 72 college women with Escherichia coli UTIs. During the 14-month study period, S saprophyticus was the second most common cause of UTIs, accounting for 11% of the total. Staphylococcus saprophyticus infections occurred more frequently during the late summer and early fall. Age, history of previous UTI, signs and symptoms of infection, and findings on urinalysis were similar in patients with S saprophyticus and E coli infections. Nine (41%) of 22 S saprophyticus infections were localized to the upper urinary tract by the antibody-coated bacteria technique compared with 18 (16%) of 115 infections with E coli (P = .01). Rectal, vaginal, and urethral colonization with S saprophyticus was associated with UTI caused by these organisms, suggesting that their pathogenesis resembles that of E coli UTIs. In vitro susceptibility testing showed almost uniform sensitivity of S saprophyticus to most antimicrobials used to treat UTIs, but recurrent infections occurred in six of the 72 women despite adequate therapy. Physicians and microbiologists must be aware that S saprophyticus is an important cause of UTIs in young women.
Efficient high-brightness diode laser modules offer new industrial applications (2007)

We present new developed high power diode laser modules which are performing at outstanding brightness and their applications. The combination of recently designed laser diode bars on passive heat sinks and optimized micro-optics results to laser modules up to 50W out of a 100μm fibre with a 0.22 NA at one single wavelength based on broad area laser bars (BALB) and up to 50W out of 50μm fibre with a 0.22 NA based on single-mode emitter array laser (SEAL) bars. The fibre coupled systems are based on diode lasers with a collimated beam of superior beam data, namely < 10 mm x 10 mm beam diameter (FW1/e<sup>2</sup>) and < 2mrad x 2mrad divergence (FW1/e<sup>2</sup>). Such free beam diode lasers deliver 30 W or 60 W output power. The applications for such laser diode modules varies from direct marking, cutting and welding of metals and other materials up to pumping of fibre lasers and amplifiers. Marking speed with up to 30mm/s on stainless steel was observed with 20W laser power and 50&mgr;m fibre with a conventional marking setup. Cutting speed of about 1m/min of 0.2mm Kovar sheet was shown with a diode laser module with 50W laser power from a 100&mgr;m fibre.
Fluorinated, crosslinkable terpolymers based on vinylidene fluoride and bearing sulfonic acid side groups for fuel‐cell membranes (2006)

Abstract The radical terpolymerization of 8‐bromo‐1 H, 1 H, 2 H ‐perfluorooct‐1‐ene with vinylidene fluoride (VDF) and perfluoro(4‐methyl‐3,6‐dioxaoct‐7‐ene) sulfonyl fluoride is presented. Changing the feed compositions of these three fluorinated comonomers enabled us to obtain different random‐type poly[vinylidene fluoride‐ ter ‐perfluoro(4‐methyl‐3,6‐dioxaoct‐7‐ene) sulfonyl fluoride‐ ter ‐8‐bromo‐1 H, 1 H, 2 H ‐perfluorooct‐1‐ene] terpolymers containing various sulfonyl fluoride and brominated side groups. Yields higher than 70% were reached in all cases. The hydrolysis of the sulfonyl fluoride group into the SO 3 Li function in the presence of lithium carbonate was quantitatively achieved without the content of VDF being affected, and so dehydrofluorination of the VDF base unit was avoided. These original terpolymers were then crosslinked via dangling bromine atoms in the presence of a peroxide/triallyl isocyanurate system, which produced films insoluble in organic solvents such as acetone and dimethylformamide (which totally dissolved uncured terpolymers). The acidification of SO 3 Li into the SO 3 H function enabled protonic membranes to be obtained. The thermal stabilities of the crosslinked materials were higher than those of the uncured terpolymers, and their electrochemical performances were investigated. According to the contents of the sulfonic acid side functions, the ion‐exchange capacities ranged from 0.6 to 1.5 mequiv of H + /g, whereas the water uptake and conductivities ranged from 5–26% (±11%) and from 0.5 to 6.0 mS/cm, respectively. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 4566–4578, 2006
Alternative splicing of parathyroid hormone-related protein mRNA: expression and stability (2004)

Parathyroid hormone-related protein (PTHrP) is a multifunctional protein that is often dysregulated in cancer. The human PTHrP gene is alternatively spliced into three isoforms, each with a unique 3'-untranslated region (3'-UTR), encoding 139, 173 and 141 amino acid proteins. The regulation of PTHrP mRNA isoform expression has not been completely elucidated, but it may be affected by transforming growth factor-beta1 (TGF-beta1). In this study, we examined differences in the PTHrP mRNA isoform expression in two squamous carcinoma cell lines (SCC2/88 and HARA), an immortalized keratinocyte cell line (HaCaT), and spontaneous human lung cancer with adjacent normal tissue. In addition, the effect of TGF-beta1 on PTHrP mRNA isoform expression and stability was examined. Cell-type specific expression of PTHrP mRNA isoforms occurred between the various cell lines, normal human lung, and immortalized human keratinocytes (HaCaT). PTHrP isoform expression pattern was significantly altered between normal lung tissue and the adjacent lung cancer. In vitro studies revealed that TGF-beta1 differentially altered the mRNA steady-state levels and mRNA stability of the PTHrP isoforms. Protein-RNA binding studies identified different proteins binding to the 3'-UTR of the PTHrP isoforms (139) and (141), which may be important in the differential mRNA stability and response to cytokines between the PTHrP isoforms. The data demonstrate that there is cell-type specific expression of PTHrP mRNA isoforms, and disruption of the normal regulation during cancer progression may in part be associated with TGF-beta1-induced changes in PTHrP mRNA isoform expression and stability.
A statistical approach to the spam problem (2003)

Can mathematics tell spam apart from legitimate mail? Find out which approaches work best in real-world tests.
Effects of acute pH 6.6 and 42.0 degrees C heating on the intracellular pH of Chinese hamster ovary cells. (1988)

Incubation of Chinese hamster ovary cells in pH 6.6 medium for 4 h prior to and during 42.0 degrees C heating enhanced thermal cell killing compared to cells heated under normal pH 7.3 conditions. We examined the relationship between the extracellular pH and intracellular pH (pHi) of Chinese hamster ovary cells using a flow cytometer with the pH-sensitive fluorescent molecule 2,3-dicyanohydroquinone. Using either normal (7.3) or low (6.6) pH conditions, the mean pHi and population pHi heterogeneity was studied as a function of time at 42.0 degrees C. Cells incubated at pH 6.6 for 4 h had a resting pHi 0.14 to 0.19 pH units lower than cells at normal pH 7.3, indicating the presence of an active pHi regulatory system. Heating 1 h at 42.0 degrees C at normal pH caused an increase in the pHi of 0.14 pH units. With further heating the cells gradually returned to the unheated (7.3) control levels. Similar pHi changes were observed with the cells incubated and heated at pH 6.6. However, the mean pHi was always more acidic than cells heated at normal pH. Active pHi regulation was still possible for a substantial (greater than 30%) number of cells even after 10 h of heating under low pH conditions. These results suggest that a breakdown in pHi regulation is not the mechanism of low pH-induced heat sensitization.
The wisdom of Sheba: Constructing feminist practical theology (2001)

This article employs the vehicle of midrash to explore the power relations implicit in male-centred theological thinking. It argues that women pastoral theologians have been slow to critique the conventions of practical theology but that it is now possible to trace the contours of an emerging feminist re-formation of the discipline. This constructive work moves beyond a critique of male dominance to explore the ambivalence of women's lives and the violence at the heart of the Christian tradition.
Reducing Access to Guns by Violent Offenders (2017)

Philip J. Cook, Harold A. Pollack, Reducing Access to Guns by Violent Offenders, RSF: The Russell Sage Foundation Journal of the Social Sciences, Vol. 3, No. 5, The Underground Gun Market: Implications for Regulation and Enforcement (October 2017), pp. 2-36
Structural basis for microtubule recognition by the human kinetochore Ska complex (2014)

The ability of kinetochores (KTs) to maintain stable attachments to dynamic microtubule structures ('straight' during microtubule polymerization and 'curved' during microtubule depolymerization) is an essential requirement for accurate chromosome segregation. Here we show that the kinetochore-associated Ska complex interacts with tubulin monomers via the carboxy-terminal winged-helix domain of Ska1, providing the structural basis for the ability to bind both straight and curved microtubule structures. This contrasts with the Ndc80 complex, which binds straight microtubules by recognizing the dimeric interface of tubulin. The Ska1 microtubule-binding domain interacts with tubulins using multiple contact sites that allow the Ska complex to bind microtubules in multiple modes. Disrupting either the flexibility or the tubulin contact sites of the Ska1 microtubule-binding domain perturbs normal mitotic progression, explaining the critical role of the Ska complex in maintaining a firm grip on dynamic microtubules.
Molecular tilt in the smectic C phase : a zigzag model (1978)

We have collected data concerning the molecular tilt angle of 4 smectic C compounds, presenting a second order transition to a smectic A phase. We have completed these data by direct measurements, using the conoscopic technique, for the tilt angle of the optical axis, and the X-ray technique, to follow the varying thickness of smectic layers. The comparison of X-rays and optical data shows a discrepancy which becomes very large for the molecules which possess long aliphatic end chains. Resuming an idea from Guillon and Skoulios, we propose a molecular model for the C phase derived from lyotropic systems: the rigid central core, optically anisotropic, imposes the tilt of the optical axis. The melted end chains are on the average closer to the normal to the layers. The rigidity parameter, ratio of the rigid core length to total length of the molecule, will be important to describe the mechanical properties of smectics.
Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms (2013)

Reactive oxygen or nitrogen species (ROS, RNS) and oxidative stress in the respiratory system increase the production of mediators of pulmonary inflammation and initiate or promote mechanisms of carcinogenesis. The lungs are exposed daily to oxidants generated either endogenously or exogenously (air pollutants, cigarette smoke, etc.). Cells in aerobic organisms are protected against oxidative damage by enzymatic and non-enzymatic antioxidant systems. Recent epidemiologic investigations have shown associations between increased incidence of respiratory diseases and lung cancer from exposure to low levels of various forms of respirable fibers and particulate matter (PM), at occupational or urban air polluting environments. Lung cancer increases substantially for tobacco smokers due to the synergistic effects in the generation of ROS, leading to oxidative stress and inflammation with high DNA damage potential. Physical and chemical characteristics of particles (size, transition metal content, speciation, stable free radicals, etc.) play an important role in oxidative stress. In turn, oxidative stress initiates the synthesis of mediators of pulmonary inflammation in lung epithelial cells and initiation of carcinogenic mechanisms. Inhalable quartz, metal powders, mineral asbestos fibers, ozone, soot from gasoline and diesel engines, tobacco smoke and PM from ambient air pollution (PM₁₀ and PM₂.₅) are involved in various oxidative stress mechanisms. Pulmonary cancer initiation and promotion has been linked to a series of biochemical pathways of oxidative stress, DNA oxidative damage, macrophage stimulation, telomere shortening, modulation of gene expression and activation of transcription factors with important role in carcinogenesis. In this review we are presenting the role of ROS and oxidative stress in the production of mediators of pulmonary inflammation and mechanisms of carcinogenesis.
Ultrafast excitonic saturable absorption in ion-implanted InGaAs/InAlAs multiple quantum wells (1998)

We report on ultrafast excitonic nonlinearities in ion-implanted InGaAs/InAlAs multiple quantum wells. We find that irradiation with energetic O+ and Ni+ ions can reduce the carrier lifetime from 1.6 ns down to 1.7 ps without significantly altering the excitonic absorption properties, making efficient fast saturable absorbers in the 1.3–1.5 μm wavelength range.