gebhart/patrepeval huggingface dataset:
ESD protection design for Giga-Hz high-speed I/O interfaces in a 130-nm CMOS process (2007)

The electrostatic discharge (ESD) protection design for high-speed input/output (I/O) interfaces in a 130-nm CMOS process is proposed in this paper. First, the ESD protection devices were designed and fabricated to evaluate their ESD robustness and the parasitic effects in giga-hertz frequency band. With the knowledge on the dependence of device dimensions on ESD robustness and the parasitic capacitance, the ESD protection circuit for high-speed I/O interfaces was designed with minimum degradation on high-speed circuit performance but satisfactory high ESD robustness.
Complexity analysis admissible heuristic search (1998)

We analyze the asymptotic time complexity of admis-sible heuristic search algorithms such as A*, IDA*, and depth-first branch-and-bound. Previous analyses relied on an abstract analytical model, and character-ize the heuristic function in terms of its accuracy, but do not apply to real problems. In contrast, our anal-ysis allows us to accurately predict the performance of these algorithms on problems such as the sliding-tile puzzles and l~ubik’s Cube. The heuristic function is characterized simply by the distribution of heuris-tic values in the problem space. Contrary to conven-tional wisdom, our analysis shows that the asymptotic heuristic branching factor is the same as the brute-force branching factor, and that the effect of a heuris-tic function is to reduce the effective depth of search, rather than the effective branching factor.
Observation of cavity quantum-electrodynamic effects in a Nd:glass microsphere (1995)

In a Nd:glass microspherical cavity the enhancement and inhibition of spontaneous-emission processes that are due to cavity QED effects have been observed. The rates of the enhanced spontaneous emission are location dependent and reach a maximum value of more than 10(3) times the free-space value. The large enhancement strongly modifies the decay processes of Nd ions in glass, and the radiative properties of Nd:glass have been changed. As a result a new spectrum including new lasing wavelengths in the Nd:glass sphere has been observed.
Fangia hongkongensis gen. nov., sp. nov., a novel gammaproteobacterium of the order Thiotrichales isolated from coastal seawater of Hong Kong (2007)

A Gram-negative, coccobacillus-shaped, aerobic bacterium, designated strain UST040201-002T, was isolated in February 2004 from seawater at the outlet of a sandfilter in Port Shelter, Hong Kong SAR, China. This strain possessed ubiquinone-8; its 16S rRNA gene sequence shared only 91% similarity with the sequence from Caedibacter taeniospiralis and 89-90% similarity with sequences from Francisella tularensis, Francisella novicida, Francisella philomiragia and Wolbachia persica. 16S rRNA gene sequence analysis showed that the strain formed a distinct clade with C. taeniospiralis. This subcluster formed a tight coherent group with members of the family Francisellaceae and W. persica. Combined phylogenetic and physiological data suggest that strain UST040201-002T represents a novel genus and species within the order Tauhiotrichales. The name Fangia hongkongensis gen. nov., sp. nov. is proposed; the type strain is UST040201-002T (=JCM 14605T=NRRL B-41860T).
Influence of Surface Chemistry on the Binding and Electronic Coupling of CdSe Quantum Dots to Single Crystal TiO<sub>2</sub>Surfaces (2010)

Sensitization of mesoporous nanocrystalline TiO(2) solar cells with quantum confined semiconductor nanocrystals (QDs) has some advantages over organic dyes or inorganic complex sensitizers, yet the reported efficiencies of laboratory devices are not currently competitive with those of dye sensitized cells. Several methods previously utilized to bind CdSe QDs to mesoporous TiO(2) films were investigated using low index faces of both anatase and rutile TiO(2) polytypes as model systems. The in situ ligand exchange method, where 3-mercaptopropionic acid (MPA) covered TiO(2) crystal surfaces are treated with trioctylphosphine (TOP)/trioctylphosphine oxide (TOPO) (TOP/TOPO)-capped CdSe QDs, resulted in very irreproducible and usually low sensitized photocurrents. The ex situ ligand exchange method, whereby MPA-capped QDs are synthesized and directly adsorbed onto bare TiO(2) single crystals, resulted in both reproducible sensitized photocurrents and surface coverages that are verified with atomic force microscopy (AFM). Purification of the nanocrystals and adjustment of the pH of the sensitization solution to >10.2 was found to prevent QD agglomeration and takes advantage of the dual chemical functionality of MPA to directly link the QDs to the TiO(2) surface. The spectral response of the incident photon to current efficiencies of CdSe QDs was directly compared to the commonly used sensitizer cis-di(thiocyanato)-bis(4,4;-dicarboxy-2,2'-bipyridine)ruthenium(II) (N3) on the same single crystals.
Effect of Aspect Ratio and Temperature on Magnetic Properties of Permalloy Nanowires (2014)

Arrays of permalloy nanowires (NWs) were fabricated into the pores of self-engineered Anodic Aluminium Oxide (AAO) templates by a simple electrodeposition technique (EDT) with a diameter -200 nm. By varying the length of the nanowires from 1.5 to 7.5 microm, got corresponding changes in aspect ratio from 7.5 to 37.5. We studied the growth and structural properties of permalloy nanowires using scanning electron microscopy, X-ray diffraction spectra and transmission electron microscopy. We performed the magnetic measurements of permalloy nanowires using vibrating sample magnetometer. The coercivity (H(c)) and anisotropy field (H(an)) observed considerably higher when the applied magnetic field was perpendicular to the nanowires axial direction (In-Plane) compare to the applied magnetic field was parallel to the nanowire axial direction (Out-of-plane). Reverse trend was observed for the maximum remanent ratio (M(r)/M(s)). So we concluded that the magnetic easy axis of the permalloy nanowires are along the axial direction of the nanowires and magnetic hardness of the nanowires higher in transverse direction compare to the axial direction of nanowires. For the first time temperature (80 K < or = T < or = 300 K) and aspect ratio dependence magnetic properties of the permalloy nanowires have been studied in detail.
Transcriptional and epigenetic regulation of autophagy in aging (2015)

Macroautophagy is a major intracellular degradation process recognized as playing a central role in cell survival and longevity. This multistep process is extensively regulated at several levels, including post-translationally through the action of conserved longevity factors such as the nutrient sensor TOR. More recently, transcriptional regulation of autophagy genes has emerged as an important mechanism for ensuring the somatic maintenance and homeostasis necessary for a long life span. Autophagy is increased in many long-lived model organisms and contributes significantly to their longevity. In turn, conserved transcription factors, particularly the helix-loop-helix transcription factor TFEB and the forkhead transcription factor FOXO, control the expression of many autophagy-related genes and are important for life-span extension. In this review, we discuss recent progress in understanding the contribution of these transcription factors to macroautophagy regulation in the context of aging. We also review current research on epigenetic changes, such as histone modification by the deacetylase SIRT1, that influence autophagy-related gene expression and additionally affect aging. Understanding the molecular regulation of macroautophagy in relation to aging may offer new avenues for the treatment of age-related diseases.
Tumor targeting in vivo and metabolic fate of 5-[iodine-125]iodo-2'-deoxyuridine following intratumoral injection in patients with colorectal cancer. (1993)

Previous studies have demonstrated the tumor-targeting potential of radioiodinated 5-iodo-2'-deoxyuridine (IUdR) in experimental animal models following direct intratumoral or intracavitary administration. The aim of this study was to measure the tumor uptake and metabolic fate of 5-[125I]iodo-2'-deoxyuridine ([125I]UdR) in humans after a single intratumoral injection. Ten patients with colorectal cancer were injected intratumorally with [125I]UdR) (0.24-3.9 MBq) during endoscopy 24 hr before ablative surgery. Blood and urine samples were collected up to 72 hr after [125I]UdR injection. Following resection, the radioactivity in the tumor and the surrounding tissues was measured in a gamma counter, and microautoradiography was performed on semi-thin tissue sections to assess localization of the radiopharmaceutical at the cellular level. An average of 0.234% of the injected dose was present per gram of tumor (range 0.009-0.918, median value 0.147), and tumor-to-nontumor radioactivity incorporation ratios were high for colonic mucosa when the nontumor tissue was taken at 1 cm (mean 629, range 27-2391) and 15 cm (mean 2387, range 122-12674) from the injection site. Microautoradiography confirmed these high tumor-to-nontumor ratios and demonstrated localization of [125I]UdR in the tumor cell nuclei. These results suggest that radioiodinated IUdR might have potential as a tumor-targeting agent in humans, provided homogeneous intratumoral distribution of the radiopharmaceutical by a suitable route of loco-regional administration can be achieved.
Spinal Muscular Atrophy: Position and Functional Importance of the Branch Site Preceding SMN Exon 7 (2007)

In spinal muscular atrophy, the SMN1 gene is deleted or destroyed by mutation, while the neigboring, nearly identical SMN2 gene acts as a partial functional substitute. However, due to a single nucleotide exchange, the seventh exon of SMN2 is mostly excluded from the mature mRNA, and the resulting shorter protein is non-functional. Here, we map the previously uncharacterized intron 6 branch point by RT-PCR. Moreover we show that exon 7 inclusion can be either abolished or improved by mutations in this branch site region.
Effervescent Redispersion of Lyophilized Polymeric Nanoparticles (2013)

This novel freeze-drying and reconstitution method offers a route to producing redispersible dry powders of nanoparticle therapeutics.
Effect of Buffer Species on the Unfolding and the Aggregation of Humanized IgG (2007)

The aggregation propensity of humanized antibody after heat treatment is evaluated in the presence of six buffer species. The comparison under equivalent pH showed high aggregation propensity on phosphate and citrate buffer. In contrast, 2-(N-Morpholino) ethane sulfonate (MES), 3-(N-Morpholino) propane sulfonate (MOPS), acetate and imidazole buffer showed lower aggregation propensity than the above two buffers. Meanwhile, unfolding temperature evaluated by differential scanning calorimetry measurement was not altered among these buffer species. The light scattering analysis suggested that heat-denatured intermediate was aggregated slightly on MES and acetate buffer. Therefore, it was found that the different aggregation propensity among buffer species was caused from the aggregation propensity of heat-denatured intermediate rather than the unfolding temperature. Furthermore, it was revealed that the aggregation dependency on buffer species is accounted for by the specific molecular interaction between buffer and IgG, rather than the ionic strength. On the contrary, on the analyses of unfolding and aggregation propensity by molecular dissection of IgG into Fab and Fc fragments, aggregation propensity of Fc fragment on MES, acetate and phosphate buffer was almost the same as whole IgG. From the above results, it was suggested that the specific interaction between buffer molecule and Fc domain of IgG was involved in the aggregation propensity of heat-denatured IgG.
A Case with Thyroid Tuberculosis Diagnosed by Non-operative Method (2002)

Tuberculosis of the thyroid gland is extremely rare, with a few surgically removed cases having been reported . The differential diagnosis, from malignancies and other non tuberculous granulomatous lesions, is impossible clinical grounds. We experienced a case of tuberculosis of the thyroid gland with palpable thyroid nodules, in a 23 year-old female patient. She was clinical and biochemically euthyroid. US and CT scans demonstrated a low density mass in the left low lobe of the thyroid gland. An FNAB showed caseous necrosis, and AFB stains demonstrated tuberculosis bacilli. We report a case of tuberculosis of the thyroid gland, diagnosed by a non-operative method.
Successive Growth of Si and SiO[sub 2] in Epitaxial Apparatus (1964)

The growth of silicon oxide layers immediately following the deposition of an epitaxial silicon film has been studied, using the reaction
Translational control of ribosomal protein L10 synthesis occurs prior to formation of first peptide bond (1981)

A simplified DNA-directed in vitro system has been developed to study the regulation of the synthesis of ribosomal protein L10 by measuring the formation of the first dipeptide, fMet-Ala. The results show that the inhibition of L10 synthesis by L10 (autoregulation) occurs at or prior to the formation of the first peptide bond.
A Guide to Developing Client/Server SQL Applications (1992)

This book is a practical introduction to database management for applications programmers, database administrators, and workstation users entering the client/server environment. It includes a tutorial on database-management concepts, explained with standard SQL, and offers a comprehensive survey of client/server technology. The authors provide a balanced presentation of database management and distributed application development, case studies comparing the capabilities and interfaces of dominant database servers such as EE, RDB, Oracle, and SQL Server. The focus is on relational database management with special emphasis on transaction processing, data integrity, security, and application programming interfaces for major commercial products. Includes: Features and performance of commercial database servers Individual SQL dialects compared to the standard Server administration requirements Benchmarking techniques SQL applications in heterogeneous environments Application programming interfaces to the servers Future directions for SQL client/server architectures
Homogeneous nucleophile exchange. 1. Simple, high-yield synthesis of some heterodihalides (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHomogeneous nucleophile exchange. 1. Simple, high-yield synthesis of some heterodihalidesRoger C. HahnCite this: J. Org. Chem. 1988, 53, 6, 1331–1333Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/jo00241a045https://doi.org/10.1021/jo00241a045research-articleACS PublicationsRequest reuse permissionsArticle Views542Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Molecular Characterization of the Tumor-Suppressive Function of Nischarin in Breast Cancer (2011)

Nischarin may be a novel tumor suppressor that limits breast cancer progression by regulating α5 integrin expression and subsequently α5 integrin-, FAK-, and Rac-mediated signaling.
Generalized Unitary Coupled Cluster Wave functions for Quantum Computation (2018)

We introduce a unitary coupled-cluster (UCC) ansatz termed k-UpCCGSD that is based on a family of sparse generalized doubles operators, which provides an affordable and systematically improvable unitary coupled-cluster wave function suitable for implementation on a near-term quantum computer. k-UpCCGSD employs k products of the exponential of pair coupled-cluster double excitation operators (pCCD), together with generalized single excitation operators. We compare its performance in both efficiency of implementation and accuracy with that of the generalized UCC ansatz employing the full generalized single and double excitation operators (UCCGSD), as well as with the standard ansatz employing only single and double excitations (UCCSD). k-UpCCGSD is found to show the best scaling for quantum computing applications, requiring a circuit depth of [Formula: see text], compared with [Formula: see text] for UCCGSD, and [Formula: see text] for UCCSD, where N is the number of spin orbitals and η is the number of electrons. We analyzed the accuracy of these three ansätze by making classical benchmark calculations on the ground state and the first excited state of H<sub>4</sub> (STO-3G, 6-31G), H<sub>2</sub>O (STO-3G), and N<sub>2</sub> (STO-3G), making additional comparisons to conventional coupled cluster methods. The results for ground states show that k-UpCCGSD offers a good trade-off between accuracy and cost, achieving chemical accuracy for lower cost of implementation on quantum computers than both UCCGSD and UCCSD. UCCGSD is also found to be more accurate than UCCSD but at a greater cost for implementation. Excited states are calculated with an orthogonally constrained variational quantum eigensolver approach. This is seen to generally yield less accurate energies than for the corresponding ground states. We demonstrate that using a specialized multideterminantal reference state constructed from classical linear response calculations allows these excited state energetics to be improved.
Time‐variable parameter and trend estimation in non‐stationary economic time series (1994)

Abstract The paper describes a general approach to the modelling of nonlinear and nonstationary economic systems from time‐series data. This method exploits recursive state space filtering and fixed interval smoothing algorithms to decompose the time‐series into long term trend and short term ‘small perturbational’ components, each of which are then modelled by linear stochastic models which may be characterised by time variable parameters. The approach is illustrated by an example which explores the relationship between the variations in quarterly GNP and Unemployment in the USA over the period 1948 to 1988 and questions previous claims about the changes in the slope of the long term trend in log e (GNP) over this same period. The paper also points out that the recursive approach to estimation facilitates the use of these methods in the development of adaptive forecasting and control systems.
Automatic identification of window regions on indoor point clouds using LiDAR and cameras (2014)

In this paper, we propose an algorithm to automatically identify window regions on exterior facing facades of buildings using interior 3D point cloud resulting from an ambulatory backpack sensor system, outfitted with multiple LiDAR sensors and cameras. We develop a set of discriminative features for the task, namely visual brightness, infrared opaqueness, and an occlusion indicator, within a Markov Random Field (MRF) framework to provide structured prediction for window or glass regions. A preprocessing classifier is trained on the features to produce node potentials, and large margin parameter training is used to boost performance. Our algorithm has been trained on data taken at the 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> floor of Cory Hall at UC Berkeley, with a total façade area of 269.1 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and has been tested on walls taken on the 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> floor of Cory Hall, a Walgreens, and an office building in San Francisco, with a total exterior façade area of 454.6 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Window regions are successfully identified with 85.5% F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> -score and 94.2% accuracy.
Morphological correlation and mean absolute error criteria (2003)

The mean absolute error criterion for signal detection and matching is linked with a morphological signal correlation (a sum of minima). Several properties of this nonlinear correlation are investigated, its performance for signal detection is compared with that of the classical (sum of products) linear correlation, and its statistical form is calculated for speckle patterns.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cloning and characterization of the promoter for the rat insulin-like growth factor-binding protein-3 gene (1995)

Insulin-like growth factor-binding protein-3 (IGFBP-3), the major IGFBP in the adult circulation, is produced by a wide range of cell and tissue types. IGFBP-3 appears to be regulated by transcriptional and/or posttranslational mechanisms in a species-, cell-, and development-specific manner. In vitro and in vivo studies suggest that a number of factors (e.g. cAMP, GH, insulin-like growth factor-I, epidermal growth factor, TSH, and FSH) can act as transcriptional regulators of IGFBP-3 in particular cell types. To address the mechanistic basis for these observations, we isolated the rat IGFBP-3 gene and began characterization and analysis of the hormonal regulation of its promoter. The rat IGFBP-3 gene is located within 2 adjacent EcoRI fragments spanning about 10 kilobases. Southern analysis indicated a single copy gene. A 1.18-kilobase fragment 5' to the translation initiation codon has been sequenced and showed 65% homology with the corresponding human IGFBP-3 sequence. The region between -100 and -1 bp relative to the transcription start site showed 85% homology. The transcription start site was 118 basepairs (bp) up-stream of the initiation codon, and a TATA box consensus was located 27 bp 5' to this CAP site. No CAAT box was present, but a CpG island was identified. Consensus sequences for a number of putative response elements (e.g. activating protein-2, insulin, TSH/insulin-like growth factor, and GH) were present within -700 bp of the CAP site. A series of 5'-truncated chloramphenicol acetyltransferase reporter constructs has been transfected into both COS-1 cells and the rat thyroid cell line FRTL-5. Both basal and hormonally responsive (TSH and phorbol ester) promoter activities have been localized within the first 472 bases of the promoter region. These data indicate that suitable transfected cell systems can be established in which additional investigations can be undertaken into the mechanisms of cell- and species-specific hormonal regulation of IGFBP-3 gene expression.
Non-destructive inline evaluation method for the gate insulator in the nodes beyond the 22nm generation (2010)

We propose a new reliability evaluation technology by using “Pulse-Photoconductivity Method” to measure the electrical and dielectrical properties of the insulator sample directly and non-destructively. We evaluate the electrical characteristics of SiO 2 and HfO 2 film by measuring the transient phenomenon of photoconductive signals and indicate the electrical leakage current vs the contaminated level of the sample insulator. The method is effective to the in-line process in next generation mass-production.