gebhart/patrepeval huggingface dataset:
A frequency tracking RAKE demodulator for multipath channels (2002)

The structure and performance of a frequency-tracking RAKE receiver for spread-spectrum HF communications are discussed. The receiver uses a frequency-tracking loop that compensates for the Doppler-induced phase offset between the correlator output signal and the channel reference to maximize the resulting signal-to-noise ratio at the output. The processing estimates the average multipath phase offset and rotates the complex samples at the correlator output to remove the estimated phase error. The performance of the loop is analyzed for single and multiple path channels in additive white Gaussian noise (AWGN), and simulation results are presented on the bit-error-rate (BER) performance of the tracking receiver. The results show that by properly setting the bandwidth of the loop it is possible to achieve BER performance within a few tenths of a decibel of an ideal RAKE demodulator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Monitoring water front advancements with down‐hole gravity sensors (2008)

Candidate time‐lapse down‐hole gravity measurands are compared for monitoring water front advancements at the inter‐well scale. The ability to sense small temporal changes to already minimal density contrasts presented by typical OWC problems drives performance requirements of new down‐hole technology being developed by Lockheed Martin (Meyer, 2007). The question naturally arises regarding which component of gravity is best observed, as the miniature interferometric device can be configured to sense one of several gravity components. The concept of measuring differential gravity is introduced and simulated data are compared to respective inline and cross gravity gradients. Distributed density contrasts associated with gradual water saturation changes due to homogeneous sweep show 50 m advancement increments are observable beginning at 200 m proximity to monitoring wells if differential gravity is measured to 1 uμGal. Likewise, a change from ideal sweep to breakout is observed at 130 m proximity. Corresponding sub‐Eötvös‐level inline and cross gradient signals are deemed unobservable. The differential gravity measurement is nominally drift‐free and immune to invaded zone irregularities, so can be collected as part of a periodic wireline service without undue concern regarding accurate downhole replacement. Permanent emplacement in i‐fields is also possible. By virtue of common mode rejection, differential gravity surveys are also free of the multiple environmental corrections typically required of surface micro‐gravity acquisitions (Hare, et. al., 1999, and Ferguson, et. al., 2007).
Mixed-Signal Circuit Design Driven by Analysis: ADCs, Comparators, and PLLs (2018)

Mixed signal circuit design often involves circuits that are time-varying or highly non-linear, which further results in systems that are difficult to characterize using established methodologies for linear time-invariant systems, thus designers are more than often forced to rely on intensive simulations for design. This dissertation explores design optimization for comparators, phase locked loops and ADC from three different perspectives.First, a complete analysis for regenerative comparators is presented including noise, offsets and speed for the first time. Despite the fact that the comparators are time-varying and regenerative with infinite gain, simple equivalent circuits still accurately capture their operation. Design guideline are provided for different comparator architectures.Second, a linearized analysis for phase locked loops using bang-bang phase detectors is presented. The high non-linear bang-bang phase detector is ascribed to an effective gain, whose physical meaning is interpreted in signal space. Closed form expressions for loop gain, output jitter and phase noise profile are obtained using transfer functions for the first time. Design guidelines are also provided.Last, a 2.5GS/s 10bit 65mW ADC in 28nm CMOS FD-SOI without active amplifier and intensive digital calibration is presented. This highlights the potential of circuit design based on complete understandings. The fabricated ADC with considerably less complexity achieves comparable performance with state-of-arts. Different imperfections are quantitatively studied and compared with measurement.
Culture Medium With Blood Analog Mechanical Properties (2007)

Culture of arteries has become increasingly important in studying atherosclerosis and the effect of clinical interventions [1]. Ideally, arterial culturing should imitate in vivo conditions within an ex vivo environment. Physiological wall shear stresses are important as they induce an atheroprotective endothelial phenotype [2], which is relevant for maintaining arterial wall integrity. The arteries in such ex vivo studies, however, are perfused with culture medium, which has a viscosity lower than blood. Previously, the culture medium has been supplemented with dextran to obtain physiological fluid viscosity and wall shear stresses. However, several researchers [3,4] reported side effects of dextran on the cells in the arterial wall independent of its effect on medium viscosity. Also, dextran increases medium osmolality to supraphysiological levels [5]. This suggests that dextran may not be the optimal substance to increase medium viscosity.
Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection (1995)

The growths of both cutaneous leishmaniasis and visceral leishmaniasis caused by Leishmania mexicana and Leishmania donovani, respectively, were measured in interleukin-4 (IL-4) knockout mice (IL-4-/-) and compared with those of similarly infected wild-type (IL-4+/+) control mice. While large, nonhealing, cutaneous lesions containing large numbers of parasites developed in IL-4+/+ mice subcutaneously infected with 5 x 10(6) L. mexicana amastigotes in the shaven rump, in IL-4-/- mice no lesions whatsoever developed and parasites were difficult to detect. Systemic spread and metastasis were also noted in IL-4+/+ but not IL-4-/- mice. In contrast, IL-4-/- mice infected intravenously with 10(7) L. donovani amastigotes were found to have consistently higher parasite burdens in their livers throughout infection than did their wild-type counterparts. However, these differences were only significant at 15 days postinfection. While the results reported here pertaining to L. donovani largely support previous studies, those related to L. mexicana provide new observations. The immunological responses of IL-4-/- and IL-4+/+ mice infected with L. mexicana were, therefore, examined both in vivo and in vitro. Although neither IL-4-/- nor IL-4+/+ mice infected with L. mexicana produced parasite-specific immunoglobulin G2a antibodies, IL-4+/+ mice, unlike IL-4-/- mice, developed significant immunoglobulin G1 antibody titers as infection progressed, indicating a Th2-influenced response in wild-type mice. In addition, IL-4-/- mice, unlike IL-4+/+ mice, developed a significant delayed-type hypersensitivity response, indicating a Th1-influenced response in IL-4-/- mice. Following in vitro stimulation, splenocytes from IL-4+/+ mice infected with L. mexicana displayed significantly higher antigen-specific proliferative responses than did IL-4-/- mice. However, gamma interferon production as measured from the supernatants of the in vitro splenocyte cultures of IL-4-/- mice was significantly higher than that from IL-4+/+ mice. This again would indicate a predominantly Th1-influenced response in the absence of a Th2 response in IL-4-/- mice infected with L. mexicana. On the other hand, at the same time point, draining lymph node cells from IL-4+/+ mice produced significantly higher quantities of IL-5 than did those from IL-4-/- mice following in vitro antigenic stimulation.(ABSTRACT TRUNCATED AT 400 WORDS)
On the thickness of hydrophobic bilayers (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the thickness of hydrophobic bilayersP. Covello, M. E. Marcondes Helene, and L. W. ReevesCite this: J. Am. Chem. Soc. 1983, 105, 6, 1469–1473Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://pubs.acs.org/doi/10.1021/ja00344a009https://doi.org/10.1021/ja00344a009research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quantitation of the large polypeptide glucagon by protein precipitation and LC/MS (2004)

We present a method for the quantitation of glucagon from rat plasma by protein precipitation and LC/MS. No internal standard was used, as a labeled standard was not available and similar peptides did not show comparable extraction characteristics to glucagon. The LC system included a Keystone C18, 300 A pore size column; a linear gradient was used with a mobile phase consisting of water and acetonitrile, each with 0.2% acetic acid and 0.02% trifluoroacetic acid. Glucagon was detected with the mass spectrometer in positive ion mode monitoring the 4+ charge state at m/z 871.7. The method had an approximated limit of detection of 1 ng/mL. The lower limit of quantitation (LLOQ) was 25 ng/mL (7.2 fmol/mL), which could be reduced with an appropriate internal standard. External calibration was used and calibration curves were found to be linear over the range from 25 to 1000 ng/mL (7.2 to 290 fmol/mL). The method showed a high degree of precision and accuracy both within and between runs at four validation points, including the LLOQ.
TNFR1‐ and TNFR2‐mediated signaling pathways in human kidney are cell type‐specific and differentially contribute to renal injury (2005)

In normal kidney, TNFR1 is expressed in glomerular and peritubular capillary EC, and some tubular cells, and colocalizes with inactive apoptosis signal-regulating kinase-1 (ASK1) phosphorylated at serine 967. Biopsies of rejecting or ischemic renal allografts, which show both tubular cell injury and proliferation, display down-regulation of TNFR1 and activation of ASK1 as well as up-regulation of TNFR2 on tubular cells, where it colocalizes with phosphorylated endothelial/epithelial tyrosine kinase (Etk). We have exploited receptor-selective muteins and evaluated phosphorylation of receptor-specific kinases to study TNF responses in situ. In organ culture, a TNFR1-specific mutein changes phosphorylation of ASK1 to threonine 845, indicative of kinase activation. A TNFR2-specific mutein down-regulates TNFR1 in glomerular EC, up-regulates TNFR2 and Etk in tubular cells, and induces phosphorylation of Etk. Wild-type TNF induces TNFR2 and Etk and activates both ASK1 and Etk but does not down-regulate TNFR1. Wild-type TNF and TNFR1-specific mutein trigger tubular cell apoptosis whereas wild-type TNF and TNFR2-specific mutein induce tubular cells to express proliferating cell nuclear antigen. Differential activation of ASK1 and Etk by regulated TNFRs in patient-derived materials provides an explanation for diverse and opposing responses to TNF at distinct sites, and an in situ bioassay of TNFR signaling.
Mesalazine inhibits the <i>β</i>‐catenin signalling pathway acting through the upregulation of μ‐protocadherin gene in colo‐rectal cancer cells (2009)

These findings suggest that mu-protocadherin might be employed as a biological marker to monitor the chemopreventive efficacy of 5-ASA.
Laminin peptides stimulate human neutrophil motility. (1994)

Laminin, isolated from Engelbreth-Holm-Swarm tumor, and 10 chemically synthesized peptides, corresponding to various regions of the laminin A and B1 chains, were compared for their abilities to stimulate human peripheral blood polymorphonuclear leukocyte (PMN) chemotaxis and chemokinesis through polycarbonate membrane filters in a 48-well microchemotaxis assay. Peptides F-9, F-11, F-12, and F-13 were derived from the B1 chain of laminin at the intersection of the cross, and six peptides were derived from the laminin A chain: peptide TG-1 from the amino-terminal top globule; peptides GD-1, GD-3, GD-6, and GD-7 from the carboxyl-terminal globular domain; and peptide AG-1 from above the carboxyl-terminal globular domain. Laminin and the peptides were evaluated over a concentration range of 1 to 200 micrograms/ml in motility assays. Six of the peptides, F-9, F-12, GD-1, GD-3, GD-6, and TG-1, stimulated human PMN migration in the absence of a gradient (chemokinesis). A fluorescein conjugate of the most active laminin peptide, GD-1, exhibited nonspecific, nonsaturable binding to PMN. Intact laminin and the other peptides failed to stimulate human PMN migration. In contrast, intact Engelbreth-Holm-Swarm laminin stimulated rabbit peripheral blood PMN chemokinesis. These results demonstrate that rabbit and human peripheral blood PMNs have divergent migratory responses to intact laminin. These findings suggest that intact basement membrane laminin does not directly stimulate human blood PMN motility in vivo, but that selected laminin peptide sequences, which may be generated during proteolytic digestion of laminin, can activate human PMN migration.
Security scanning at 94GHz (2006)

It is well known that millimetre waves can pass through clothing. In short range applications such as in the scanning of people for security purposes, operating at W band can be an advantage. The size of the equipment is decreased when compared to operation at Ka band and the equipments have similar performance. In this paper a W band mechanically scanned imager designed for imaging weapons and contraband hidden under clothing is discussed. This imager is based on a modified folded conical scan technology previously reported. In this design an additional optical element is added to give a Cassegrain configuration in image space. This increases the effective focal length and enables improved sampling of the image and provides more space for the receivers. This imager is constructed from low cost materials such as polystyrene, polythene and printed circuit board materials. The trade off between image spatial resolution and thermal sensitivity is discussed.
The development of impermeable layer under straw mulch in a soil management trail (1963)

Following the death of peach trees under a straw mulch system of management at Scoresby Horticultural Research Station, the soil moisture relations of mulch, cover crop, and pasture systems of management were studied. Examination of soil moisture levels indicated the presence of an impermeable layer under mulch. This was supported by results of investigations into surface run-off and porosity and by visual examination. It is suggested that trees died from surface waterlogging above the impermeable layer.
Sustained Activity of Calcium Release-activated Calcium Channels Requires Translocation of Mitochondria to the Plasma Membrane (2006)

A rise of the intracellular Ca(2+) concentration has multiple signaling functions. Sustained Ca(2+) influx across plasma membrane through calcium release-activated calcium (CRAC) channels is required for T-cell development in the thymus, gene transcription, and proliferation and differentiation of naïve T-cells into armed effectors cells. Intracellular Ca(2+) signals are shaped by mitochondria, which function as a highly dynamic Ca(2+) buffer. However, the precise role of mitochondria for Ca(2+)-dependent T-cell activation is unknown. Here we have shown that mitochondria are translocated to the plasma membrane as a consequence of Ca(2+) influx and that this directed movement is essential to sustain Ca(2+) influx through CRAC channels. The decreased distance between mitochondria and the plasma membrane enabled mitochondria to take up large amounts of inflowing Ca(2+) at the plasma membrane, thereby preventing Ca(2+)-dependent inactivation of CRAC channels and sustaining Ca(2+) signals. Inhibition of kinesin-dependent mitochondrial movement along microtubules abolished mitochondrial translocation and reduced sustained Ca(2+) signals. Our results show how a directed movement of mitochondria is used to control important cellular functions such as Ca(2+)-dependent T-cell activation.
Warmstarting of Model-Based Algorithm Configuration (2018)

The performance of many hard combinatorial problem solvers depends strongly on their parameter settings, and since manual parameter tuning is both tedious and suboptimal the AI community has recently developed several algorithm configuration (AC) methods to automatically address this problem. While all existing AC methods start the configuration process of an algorithm A from scratch for each new type of benchmark instances, here we propose to exploit information about A's performance on previous benchmarks in order to warmstart its configuration on new types of benchmarks. We introduce two complementary ways in which we can exploit this information to warmstart AC methods based on a predictive model. Experiments for optimizing a flexible modern SAT solver on twelve different instance sets show that our methods often yield substantial speedups over existing AC methods (up to 165-fold) and can also find substantially better configurations given the same compute budget.
SHARP: Spectrum Harvesting with ARQ Retransmission and Probing in Cognitive Radio (2013)

In underlay cognitive radio, a secondary user transmits in the transmission band of a primary user without serious degradation in the performance of the primary user. This paper proposes a method of underlay cognitive radio where the secondary pair listens to the primary ARQ feedback to glean information about the primary channel. The secondary transmitter may also probe the channel by transmitting a packet and listening to the primary ARQ, thus getting additional information about the relative strength of the cross channel and primary channel. The method is entitled Spectrum Harvesting with ARQ Retransmission and Probing (SHARP). The probing is done only infrequently to minimize its impact on the primary throughput. Two varieties of spectrum sharing, named conservative and aggressive SHARP, are introduced. Both methods avoid introducing any outage in the primary; their difference is that conservative SHARP leaves the primary operations altogether unaffected, while aggressive SHARP may occasionally force the primary to use two instead of one transmission cycle for a packet, in order to harvest a better throughput for the secondary. The performance of the proposed system is analyzed and it is shown that the secondary throughput can be significantly improved via the proposed approach, possibly with a small loss of the primary throughput during the transmission as well as probing period.
Imported malaria in the 1990s: a review of 101 patients (2001)

Imported malaria remains a difficult problem in nonendemic areas of the world. We describe the clinical presentation of 101 cases of malaria diagnosed at the Leuven University Hospital between 1 January 1990 and 31 December 1999. Ninety-three patients (92%) presented initially at the emergency department. Diagnosis was initially not suspected by the referring physician in 48 patients (47%). Plasmodium falciparum was the commonest species, accounting for 67% of the cases. All but three patients had fever as the presenting symptom, but only 10 had a typical tertian fever pattern. Haemolytic anaemia, thrombocytopenia and hyponatraemia represented a typical triad in 20% of the cases. Only 13% of the malaria patients had taken correct chemoprophylaxis according to WHO recommendations. Eighty-three per cent of the patients were admitted to the hospital with a median duration of hospitalization of 4 days. All complications occurred in cases with P. falciparum. All patients were cured.
Topical Antiandrogens (1985)

The interaction between androgenic hormones and the skin has been a fascinating area of research that has tantalized dermatologists for several decades. Hirsutism, balding, and acne are all androgen-related disorders. Elevated levels of circulating androgens have recently been discovered in at least 80% of women suffering from hirsutism<sup>1</sup>and, to a lesser extent, in women with female-pattern hair loss and acne.<sup>2</sup>However, some obvious questions persist: Why does androgen cause hair to grow in some areas, such as the face, but cause it to regress to vellus hairs in other areas, such as the scalp? Why, with similar degrees of hyperandrogenemia, does severe acne develop in one woman and hirsutism in another? Answers to these questions seem to lie within the skin itself. An understanding of the response of the skin and its appendages to circulating hormones requires innovative research. We would all like to see a topical
Cone clustering principles for parallel logic simulation (2003)

Parallelization following the replicated worker principle can significantly accelerate functional logic simulation of microprocessor structures. Successful application of this method strongly depends on circuit model partitioning. We have developed a hierarchical partitioning strategy with prepartitioning and main partitioning as core phases that appear as bottom-up cone clustering. Cones can be seen as special areas of combinational logic which have the ability to directly influence storing or output elements of a circuit model under consideration. We describe and compare three of our cone clustering techniques which are based on a formal model of parallel logic simulation. Experimental results are given with respect to IBM processor structures ranging in their size from several hundred thousand to several million basic elements at a mixture of register-transfer- and gate level.