gebhart/patrepeval huggingface dataset:
Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model (2016)

The objective of the study is to formulate and evaluate a topical herbal gel containing Cardiospermum halicacabum and Vitex negundo leaf extracts for their anti-arthritic activity in rats. Twelve herbal gel formulations were prepared using 1.5% of gelling agents carbopol 934 (F1-F6) and carbopol 940 (F6-F12) and they were evaluated for physical appearance, net content, viscosity, extrudability, pH, spreadability, in vitro diffusion profile and primary skin irritation tests. The stability study for the topical herbal gel formulation was done as per ICH guidelines and anti-arthritic activity was evaluated by Freund's Complete Adjuvant (FCA) induced arthritis method. Assessment of body weight, paw volume, hematological and biochemical parameters, histopathological examination and In vitro determination of serum biomarkers were also carried out. Formulated gels were homogenous, stable and complied with the guidelines. Among the formulations, F4 showed better release (98.4 %) characteristics than other formulations. No erythema or edema was observed in the skin irritation test confirming the gel was nontoxic and safe. Topical application of the herbal gel F4 containing carbopol 934 displayed significant (p < 0.001) anti-arthritic activity compared to diseased rats. Reduction in paw volume, no agglutination in C -reactive protein and rheumatic factor, reduction in TNF level, regaining of normal hematological, and biochemical parameters, reduction in spleen and thymus weight and histopathological examination supported the anti-arthritic activity of the gel formulation.
On the Forced Resonant Characteristics of Partially Filled Electrically Small Cavity with Loaded Reactance (2001)

This paper presents the farced resonant characteristics of an electrically small cavity partially filled with dielectric material. The method of moments with Galerkins procedure is used to determine the farced resonant characteristics of the small cavity. In order to obtain the equations of the external reactance gives rise to the farced resonance at a given frequency, the cavity with external reactance can be treated as two-port network which has the admittance parameters. Numerical results show that the forced resonance, series or parallel resonance, can be obtained by the controlling the external reactance. To verify the availability of the theoretical analysis, experiments are carried out for the bakelite as the material by measuring the length of external reactance at operating frequencies.
UAV Pose Posterior Estimation with Vision Constraint (2013)

To estimate UAV (unmanned aerial vehicle) pose relative to airfield runway, a posterior parameter estimation method using the runway image and onboard pose sensors is presented.Firstly, pose parameters of UAV are measured by onboard sensors such as altimeter, GPS (global positioning system) and INS (inertial navigation system).Supposing the prior probability distribution of each parameter's measurement error is given and all errors are independent, the measured values from sensors can be considered as a sample of real ones.At the same time of sampling, an image of the runway is acquired from onboard calibrated camera, and the two edge lines of the runway are assumed to be extracted exactly from the image.Subject to the constraint of the perspective view of two parallel lines, the real parameters must locate on a constraint surface in the parameter space, and thereby the posterior mean estimation of the parameters can be obtained.Simulation results show that the method is effective.
An interactive distributed simulator for commercial power plant (1997)

This paper presents the details of a power plant distributed simulator with interactive graphical user interface. To enhance the performance of a large-scale simulation model for a commercial power plant, centralized simulation on a single processor is replaced by several concurrent simulations distributed over a network. These decentralized simulations are defined as the subsystems: boiler, turbine-generator, feedwater, and condensate. To maintain the fidelity of a central integration, the subsystems communicate interaction data among themselves using the TCP/IP protocol via a shared memory. The shared memory is utilized further in developing a graphical user interface to provide interactive simulation control while masking the internal complexities and management of multiple simulation programs over a network.
Matched Filter Processing for Asteroid Detection (2005)

Matched filter (MF) processing has been shown to provide significant performance gains when processing stellar imagery used for asteroid detection, recovery, and tracking. This includes extending detection ranges to fainter magnitudes at the noise limit of the imagery and operating in dense cluttered star fields as encountered at low Galactic latitudes. The MF software has been shown to detect 40% more asteroids in high-quality Spacewatch imagery relative to the currently implemented approaches, which are based on moving target indicator (MTI) algorithms. In addition, MF detections were made in dense star fields and in situations in which the asteroid was collocated with a star in an image frame, cases in which the MTI algorithms failed. Thus, using legacy sensors and optics, improved detection sensitivity is achievable by simply upgrading the image-processing stream. This in turn permits surveys of the near-Earth asteroid (NEA) population farther from opposition, for smaller sizes, and in directions previously inaccessible to current NEA search programs. A software package has been developed and made available on the NASA data services Web site that can be used for asteroid detection and recovery operations utilizing the enhanced performance capabilities of MF processing.
The Vaginal Radical Operation of Cervical Cancer (1995)

Choosing the surgical technique for the cervix carcinoma--vaginal or abdominal--it is particularly necessary to take into account the lymphatic spread of the cervix. As it is not possible to realize a lymphadenectomy in a vaginal procedure, it has to be found a preoperative diagnostic method which enables very surely the exclusion of lymph node involvement. In summary of the facts stated up to now, one can conclude as follows: 1. The FIGO-classification is too subjective. 2. There is a significant correlation between tumor volume and lymph node involvement. 3. The tumor markers--as e.g. PCNA, p53, c-neu, EGF, beta 1 Integrin etc.--show no correlation with the lymph node involvement. 4. Only MRI allows an exact preoperative measurement of the tumor volume. 5. On account of the above mentioned results, it seems to be possible to extend the indication for the vaginal radical surgery on cases with a small tumor volume.
Unsupervised classification and clustering of image features for vehicle detection in large scale aerial images (2010)

This paper presents a set of algorithms for vehicle detection in large scale aerial images. Vehicles are detected based on geometric and radiometric features, extracted within a multiresolution linear Gaussian scale-space. The image features, described by their local structures, are classified using support vector machines. Classified features are then clustered by an unsupervised affine propagation clustering algorithm, within a feature-level fusion scheme. Subcomponent of vehicles' body parts are aggregate together with respect to shared spatial relations and based on constraints on the orientation of detected vehicles. Experimental results using large scale aerial imagery demonstrate the efficient and robustness of the proposed algorithms for the detection of vehicles in an urban environment.
High-dose levothyroxine for the management of bipolar affective disorder: two case reports (2017)

In this article, we report two cases from our centre: case A has the longest recovery period and case B is one of the most complex from a diagnostic and management perspective, highlighting how treatment resistance can be overcome depending on patient response and needs.
Clinical pharmacokinetics of tanaproget, a nonsteroidal progesterone receptor (PR) agonist, in healthy cycling women during 28 days of administration (2005)

Background Tanaproget is a novel, selective, nonsteroidal PR agonist being studied for contraception. An objective of the study was to characterize the pharmacokinetics of tanaproget after multiple oral doses in healthy cycling women over a range of doses. Methods This multicenter, randomized, double-blind, sequential-group ascending multiple-dose study of tanaproget was conducted in healthy women aged 18 to 35. Once-daily oral doses of 0.01, 0.03, 0.1, 0.3, and 1 mg of tanaproget were administered for 28 days starting at the beginning of the subject's menstrual cycle in up to 8 subjects per cohort. In each cohort 2 subjects received placebo. Pharmacokinetic profiles were obtained at scheduled intervals after tanaproget administration on days 1, 14, and 28, with trough samples collected on days 7 and 21. Tanaproget plasma concentrations were determined using a validated LC/MS/MS assay. Noncompartmental methods were used to analyze the data. Results Tanaproget was safe and well tolerated. Tanaproget was absorbed rapidly and dose proportionality was observed for the exposure parameters Cmax and AUC. On day 14, near the time of ovulation, at the predicted therapeutic dose (0.3 mg), Cmax and AUC were 663 pg/mL and 3327 pg-h/mL, respectively. The mean elimination t1/2 was 16 hours, and drug accumulation was modest. Conclusions Tanaproget has an acceptable safety and pharmacokinetic profile for a once-daily oral contraceptive. Clinical Pharmacology & Therapeutics (2005) 77, P44–P44; doi: 10.1016/j.clpt.2004.12.060
Investigation of dynamic characteristic of forward swept folding wing (2011)

In order to investigate the dynamic characteristic of the aircraft with forward swept folding wing, the finite element model of the forward swept folding wing was modeled in the commercial finite element analysis software MSC Patran, and the corresponding modal analysis was performed using the SOL 103 solution sequence in the MSC Nastran. The influences of folding angle, stiffness of the inner hinge and the stiffness of the outer hinge on the modal parameters of the wing are investigated based on a series of finite element model. The results show that the influence of the stiffness of the hinge on the first four modes can be neglected if the stiffness of the hinge is bigger than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> Nm.
Activation of paternally expressed genes and perinatal death caused by deletion of the<i>Gtl2</i>gene (2010)

The Dlk1-Gtl2 imprinting locus is located on mouse distal chromosome 12 and consists of multiple maternally expressed non-coding RNAs and several paternally expressed protein-coding genes. The imprinting of this locus plays a crucial role in embryonic development and postnatal growth. At least one cis-element, the intergenic differentially methylated region (IG-DMR) is required for expression of maternally expressed genes and repression of silenced paternally expressed genes. The mechanism by which the IG-DMR functions is largely unknown. However, it has been suggested that the unmethylated IG-DMR acts as a positive regulator activating expression of non-coding RNAs. Gtl2 is the first non-coding RNA gene downstream of the IG-DMR. Although its in vivo function in the mouse is largely unknown, its human ortholog MEG3 has been linked to tumor suppression in human tumor-derived cell lines. We generated a knockout mouse model, in which the first five exons and adjacent promoter region of the Gtl2 gene were deleted. Maternal deletion of Gtl2 resulted in perinatal death and skeletal muscle defects, indicating that Gtl2 plays an important role in embryonic development. The maternal deletion also completely abolished expression of downstream maternally expressed genes, activated expression of silenced paternally expressed genes and resulted in methylation of the IG-DMR. By contrast, the paternal inherited deletion did not have this effect. These data strongly indicate that activation of Gtl2 and its downstream maternal genes play an essential role in regulating Dlk1-Gtl2 imprinting, possibly by maintaining active status of the IG-DMR.
A computer-based adaptive associative memory in support of design and planning (1991)

Continuing research on the organization and functionalities of a type of computer-implemented associative memory is discussed. The associative memory in question is being created to serve as part of a feature-based design system used primarily in support of the design, fabrication planning, or inspection planning of discrete mechanical machine parts. The development work is consonant with prior related work in the realm of case-based reasoning, especially as related to the role of memory in design. The associative memory innovations are in the use of fuzzy sets and neural net computing in the representation, storage and retrieval of design, fabrication, inspection, and materials knowledge. A considerable portion of the associative memory has been designed and implemented, and retrieval of previous designs on the basis of qualitative geometry has been demonstrated. Ability to explore materials composition with the objective of meeting critical materials properties constraints has been demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Evaluation of Contact Columns for Nitrogen Dioxide Absorption (1965)

The absorption efficiencies of 6–, 10–, IS–, and 60-turn spiral contact columns for two formulations of Saltzman reagent are evaluated for use in atmospheric nitrogen dioxide analyzers at several air and liquid flow rates. Response times for the several columns as a function of flow rates and absorbing reagent are also given. The recommended column and reagent are indicated. The technique of adjusting instrument parameters for direct readout of NO2 concentrations is described.
Flavanone O-glycosides from the rhizomes of Dryopteris sublaeta. (2007)

The aim of this study was to look for the chemical constituents from the rhizomes of Dryopteris sublaeta. The fresh plant was extracted twice with boiling water, the extract was concentrated to small volume under reduced pressure at 50 degrees C. The concentrated material was partitioned with ether, ethyl acetate and n-butanol. The fraction of ethyl acetate was repeatedly chromatographied over silica gel and Sephadex LH-20 columns. Structures of pure compounds were established on the basis of their physiochemical and spectral data. Nine compounds were obtained and identified as sublaetentin A (1), sublaetentin B (2), sublaetentin C (3), sublaetentin D (4), matteuorienate A (5), matteuorienate C (6), arbutin (7), 3-methoxy-4-hydroxyphenyl-1-O-beta-D-glucopyranoside (8) and 3,4-dimethoxyphenyl-1-O-beta-D-glucopyranoside (9). Compounds 1 - 4 are new compounds, the others were isolated from this plant for the first time.
Electrochemical Capacitor of MnFe[sub 2]O[sub 4] with NaCl Electrolyte (2005)

Ferrites including where , Fe, Co, or Ni have been synthesized by solution methods and tested for their capacitive behaviors in aqueous NaCl solution. has been found to exhibit unusually large capacitances, while the other ferrites do not. The results indicate unique pseudocapacitive property associated with the ions at the tetrahedral sites in the spinel structure. The pseudocapacitance was observed only for crystalline, rather than amorphous, phase, which has exhibited specific capacitances of and high-power delivering capabilities of .
Construction and characterization of F plasmid-based expression vectors (1998)

A low-copy expression vector has been constructed from a 9 Kbp region of the Escherichia coli F plasmid containing the oriV and oriS origins of replication. This plasmid carries the beta-lactamase gene (Apr) and the araBAD promoter/araC regulator for arabinose-inducible gene expression. A derivative which carries a lacZ reporter gene was found to be stably maintained for at least 150 generations. A related multi-copy plasmid was stably maintained in arabinose-free medium, but no plasmid-bearing segregants remained after 60 generations when lacZ expression was induced. Induced expression resulted in 27% (multi-copy) and 12% (low-copy) decreases in growth rate. The uninduced levels of beta-galactosidase were 200 units (multi-copy) and 15 units (low-copy).
A crustacean neuronal cytoskeletal protein with characteristics of neurofilaments and microtubule‐associated proteins (1992)

The purpose of this study was to characterize further a unique protein that is a component of the cytoskeleton of crayfish neurons. This protein, referred to as P600, is unique because it is unusually large (Mr greater than 600 kD), and because it has characteristics in common with both mammalian microtubule-associated proteins and neurofilaments. Immunohistochemical techniques have shown that P600 colocalizes with microtubules and is a component of the fibrous side-arms that extend from microtubules (Weaver and Viancour, Brain Res. 544:49, 1991). We have developed a method for obtaining purified P600 by using gel filtration techniques. When viewed by negative staining electron microscopy, P600 obtained by that method produced 11 nm-wide beaded filaments. The number of filaments was strictly related to the P600 concentration in a column fraction. A small amount of P600 consistently copurified with taxol-stabilized microtubules. The proportion copurifying with microtubules was increased by using apyrase to deplete ATP, or by using a nonhydrolyzable ATP analogue to compete with ATP. Immunogold labeling localized P600 near the ends of a subset of the fibrous side-arms extending from endogenous axonal microtubules. Several polyclonal antibodies against mammalian microtubule-associated proteins were tested for P600 labeling on immunoblots, and positive labeling was obtained with an antiserum directed against a region of microtubule-associated protein 1B that has microtubule binding activity. Epitope homology between P600, mammalian microtubule-associated protein 1B, and the mammalian mid-molecular weight neurofilament subunit is discussed in the context of possible evolutionary relationships among these cytoskeletal proteins.
Multivalent H-bonds for self-healing hydrogels (2012)

UPy is used as a reversible and dynamic crosslinker to prepare hydrogels that are injectable and undergo rapid self-healing in response to damage.
Monolithic integration of elliptic-symmetry diffractive optical element on silicon-based 45° micro-reflector (2009)

A monolithically integrated micro-optical element consisting of a diffractive optical element (DOE) and a silicon-based 45 degrees micro-reflector is experimentally demonstrated to facilitate the optical alignment of non-coplanar fiber-to-fiber coupling. The slanted 45 degrees reflector with a depth of 216 microm is fabricated on a (100) silicon wafer by anisotropic wet etching. The DOE with a diameter of 174.2 microm and a focal length of 150 microm is formed by means of dry etching. Such a compact device is suitable for the optical micro-system to deflect the incident light by 90 degrees and to focus it on the image plane simultaneously. The measured light pattern with a spot size of 15 microm has a good agreement with the simulated result of the elliptic-symmetry DOE with an off-axis design for eliminating the strongly astigmatic aberration. The coupling efficiency is enhanced over 10-folds of the case without a DOE on the 45 degrees micro-reflector. This device would facilitate the optical alignment of non-coplanar light coupling and further miniaturize the volume of microsystem.
Crown Ether-Doped Sol−Gel Materials for Strontium(II) Separation (2000)

Hybrid organic/inorganic sol-gel materials containing an encapsulated crown ether ligand were found to selectively remove 91.4 +/- 1.3% of Sr2+ from a solution containing excess of competing ions such as Ca2+. The crown ether ligand, 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7,16-bis(malonate) ligand (Na4oddm), with known high affinity for Sr2+ was encapsulated in hydrophilic SiO2 through a simple sol-gel process. Washing the Sr(2+)-loaded gel with acid or ethylenediaminetetraacetic acid disodium salt recovered the Sr2+ from the sol-gel sorbent and regenerated the doped gel for subsequent Sr2+ intake. The approach reported here is a new alternative to the use of crown ethers in metal ion separation through, for example, solvent extraction or the use of sorbents containing chemically grafted crown ether ligands.
11-oxygenated C19 steroids as circulating androgens in women with polycystic ovary syndrome (2018)

11-oxygenated C19 steroids (11oxC19s) are newly specified human androgens. Although median serum levels of 11oxC19 were reported to be higher in patients with polycystic ovary syndrome (PCOS) than in unaffected women, inter-individual variations in androgen levels among PCOS patients have poorly been investigated. Here, we quantified four 11oxC19s, i.e., 11-ketotestosterone (11KT), 11β-hydroxytestosterone (11OHT), 11β-hydroxyandrostenedione (11OHΔ4A), and 11-ketoandrostenedione (11KΔ4A), in blood samples of 28 PCOS patients and 31 eumenorrheic women using liquid chromatography-tandem mass spectrometry. We referred to our previous data of classic androgens in these individuals. We found that 11OHT levels were higher in the PCOS group than in the eumenorrheic group. Moreover, although the median values of 11KT, 11KΔ4A, and 11OHΔ4A were comparable between the two groups, these steroids were markedly increased in some patients. Of the 28 patients, 8 had high levels of both 11oxC19s and classic androgens, whereas 4 had an increase only in 11oxC19 levels, and 12 had an increase only in classic androgen levels. Intragroup variations in androgen levels were relatively large in the PCOS group. Levels of 11OHT and 11KT were significantly higher in overweight/obese patients than in normal weight patients and correlated with body mass indexes. These results highlight the clinical significance of 11oxC19s as circulating androgens in PCOS patients and indicate that the accumulation of 11oxC19s and/or classic androgens is an essential feature of PCOS. The profiles of circulating androgens appear to vary among patients. In particular, overweight/obesity likely enhances the 11oxC19s accumulation in PCOS, although this notion awaits further validation.
Suppression of boron penetration in p/sup +/ polysilicon gate P-MOSFETs using low-temperature gate-oxide N/sub 2/O anneal (1994)

It has been reported that high-temperature (/spl sim/1100/spl deg/C) N/sub 2/O-annealed oxide can block boron penetration from poly-Si gates to the silicon substrate. However, this high-temperature step may be inappropriate for the low thermal budgets required of deep-submicron ULSI MOSFETs. Low-temperature (900/spl sim/950/spl deg/C) N/sub 2/O-annealed gate oxide is also a good barrier to boron penetration. For the first time, the change in channel doping profile due to compensation of arsenic and boron ionized impurities was resolved using MOS C-V measurement techniques. It was found that the higher the nitrogen concentration incorporated at Si/SiO/sub 2/ interface, the more effective is the suppression of boron penetration. The experimental results also suggest that, for 60/spl sim/110 /spl Aring/ gate oxides, a certain amount of nitrogen (/spl sim/2.2%) incorporated near the Si/SiO/sub 2/ interface is essential to effectively prevent boron diffusing into the underlying silicon substrate.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>