gebhart/patrepeval huggingface dataset:
A 1.1-mW Ground Effect-Resilient Body-Coupled Communication Transceiver With Pseudo OFDM for Head and Body Area Network (2017)

This paper presents a body-coupled communication (BCC) transceiver (TRX) that mitigates all the practical impairments of the body channel at once. The proposed pseudo orthogonal frequency-division multiplexing (P-OFDM) TRX combines baseband BPSK-OFDM with frequency-shift keying (FSK) to alleviate the impacts of variable ground effect and variable skin-electrode contact impedance, which have been the two major issues on the BCC. It can tolerate up to 20 dB of channel gain variation with measured bit error rate improvement of >70% compared to FSK modulation alone. The RC relaxed contact impedance monitor continuously monitors and compensates the variable skin-electrode contact impedance at both transmitter (TX) and receiver (RX). The proposed power-gated 8-point inverse fast Fourier transform/fast Fourier transform with no floating-point multipliers (FPMs) reduces the gate count and power by 54% and 30% compared to conventional FPMs, respectively. Additionally, the simple floating-point adder (FPA) reduces the gate count and energy consumption by 34% and 20% compared to conventional FPAs, respectively. A high input impedance glitch-free FSK demodulation RX with variable threshold limiter and all digital cycle correction is also proposed to support a scalable data rate (200 Kbps-2 Mbps). The 0.54 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> TRX in 65-nm CMOS consumes 1.1 mW.
Limits of Parabolic Flow Theory in Microfluidic Particle Separation: A Computational Study (2013)

Microfluidic particle separation technologies are useful for enriching rare cell populations for academic and clinical purposes. In order to separate particles based on size, deterministic lateral displacement (DLD) arrays are designed assuming that the flow profile between posts is parabolic or shifted parabolic (depending on post geometry). The design process also assumes the shape of the normalized flow profile is speed-invariant. The work presented here shows flow profile shapes vary, in arrays with circular and triangular posts, from this assumption at practical flow rates (10 < Re < 100). The root-mean-square error (RMSE) of this assumption in the circular post arrays peaked at 0.144. The RMSE in the triangular post array peaked at 0.136. Flow development occurred more rapidly in circular post arrays when compared to triangular post arrays. Additionally, the changes in critical bumping diameter (DCB) the DLD design metric used to calculate the size-based separation threshold were examined for 10 different row shift fractions (FRS). These errors correspond to a DCB that varies as much as 11.7% in the circular post arrays and 15.1% in the triangular post arrays.
Visible Light Activatable Binary System of Oligonucleotide Conjugates for Nucleic Acids Modification (1999)

Abstract A binary system of oligonucleotides conjugated to perfluoroarylazide and perylene for sequence-specific photomodification of nucleic acids has been developed. The system can be activated by visible light (450-580 nm), reacts 300000 times faster than azide in the absence of perylene and provides highly efficient (up to 99%) photomodification of target ssDNA.
Analysis and design of a constant frequency diode-clamped series resonant converter (1991)

A constant frequency diode-clamped series resonant power converter (CFCSRC) is proposed as a solution to problems associated with frequency-controlled resonant converters. This converter has two resonant frequencies, and control is achieved by varying the relative time per switching cycle spent at each resonant frequency. Two zero-current-switching (ZCS) modes are examined and plotted in the output plane. Operating and mode boundaries are found and also plotted in the output plane. The output equation for the main mode is shown to be hyperbolic. Peak voltages are shown to be less than or equal to the input voltage, and peak currents are shown to be less than those of the frequency-controlled diode-clamped series resonant converter over a large operating range. A design procedure is given in the form of a design example. Data from a prototype converter is plotted with theoretical data in the output plane and good agreement with the theoretical model is obtained.
LA INTERPRETACIÓN MUSICAL COMO HÁBITO: DIVERSIDAD EN EL DEPARTAMENTO DE MÚSICA DE LA UNIVERSIDAD EAFIT DESDE UNA PERSPECTIVA SEMIÓTICA (2018)

En el presente artículo el autor reflexiona, a la luz de la semiótica peirceana, en torno a la diversidad que se da en la interpretación musical a partir de la partitura, en las diferentes líneas de énfasis que alberga el Departamento de Música de la Universidad EAFIT. De igual manera, revisa de manera crítica algunos de los paradigmas fundacionales comunes a casi todas las escuelas de la denominada música culta occidental, como son su histórica postura antilogocentrista, la preeminencia de la intentio auctoris por sobre otras intenciones en la interpretación, el canon de la música clásica, la plurivocidad del texto escrito y el interpretante final como hábito de comportamiento, entre otros; con algunas digresiones a los conceptos de la différance derridana y la distinción aristotélica entre la poiesis y la praxis.
Relaxin inhibition of KCl-induced uterine contractions <i>in vitro</i>: an alternative bioassay (1981)

The effect on the rat uterus of the ovarian peptide hormone, relaxin, has been studied in vitro. Partial (20%) replacement of the NaCl in physiological saline by KCl resulted in a strong contraction of the uterus which was reversed by relaxin. The preparation contracted by this level of KCl substitution was shown to be very sensitive to the action of extracts of pregnant sow ovaries containing relaxin in comparison with the ones contracted by higher and lower degrees of KCl substitution. The ovarian extracts induced a concentration-dependent reversal of the contraction of the uterus; this activity of relaxin increased with the degree of purification of the hormone. Relaxin induced a slowly developing relaxation whereas epinephrine relaxed the same preparation very rapidly until a plateau relaxation was reached. The concentration-response curves to relaxin at different states of purification were parallel and were also parallel and comparable in potency to the ones measured for similar preparations from other laboratories. These results suggest that rat uterus contracted in vitro by KCl-substituted saline should be a valuable and reproducible bioassay for relaxin.
Essential Oil of<i>Eugenia melanadenia</i>Krug et Urb. from Cuba (2003)

Abstract The chemical composition of the essential oil obtained from the leaves of Eugenia melanadenia Krug et Urb. from Cuba was examined by combined GC/MS. The oil was characterized by the presence of 1,8-cineole (45.3%), terpinen-4-ol (10.6%), p-cymene (8.2%), β-eudesmol (7.0%) and α-terpineol (6.7%) as major constituents.
Absolute energy calibration of low-pressure proportional counters containing hydrogen (1973)

Translated from Prib. Tekh. Eksp.; 16: No. 3, 71-74(1973). An operative method is proposed for the absolute energy calibration of low-pressure counters containing hydrogen which are designed for the spectrometry of neutron radiation in the energy range from 5 to 200 keV. The method is based on comparing the calculated spectrum of energy evolution of /sup 3/He(n,p)T-reaction products in the sensing volume of the detector with the experimental amplitude distribution of pulses that develops when the detector is irradiated with thermal neutrons. (auth)
An artificial discourse language for collaborative negotiation (1994)

Collaborations to accomplish common goals necessitate negotiation to share and reach agreement on the beliefs that agents hold as part of the collaboration. Negotiation in communication can be simulated by a series of exchanges in which agents propose, reject, counterpropose or seek supporting information for beliefs they wish to be held mutually. In an artificial language of negotiation, messages display the state of the agents&apos; beliefs. Dialogues consisting of such messages clarify the means by which agents come to agree or fail to agree on mutual beliefs and individual intentions. Introduction In human problem solving, agents often recognize that they share goals in common. To achieve their common goals, they plan and act jointly. These activities are collaborative processes. Collaboration requires negotiation, that is, the interactive process of attempting to agree on the goals, actions and beliefs that comprise the planning and acting decisions of the collaboration. This paper re...
Fertilizing Capacity of Bovine Sperm may be Maintained by Binding to Oviductal Epithelial Cells1 (1991)

The ability of the bovine oviduct to maintain the motility and fertilizing capacity of bovine sperm was investigated by incubating frozen-thawed sperm with endosalpingeal epithelial cells cultured on either tissue culture plastic (nonpolarizing) or Matrigel-coated Millicell (polarizing) substrata. Sperm were also incubated in medium alone or with cultured bovine tracheal epithelial cells. Motility was determined at 6-h intervals over a 48-h period. The fertilizing capacity of sperm was evaluated after 0, 24, and 30 h of incubation by adding oocytes to the culture and determining the incidences of fertilization and polyspermy. Motility was maintained for 48 h in sperm that bound to endosalpingeal epithelial cells, but to a greater extent with polarized cells (38.4% motile) than with nonpolarized cells (0.8%). Fertilizing capacity was maintained for 30 h in sperm incubated with endosalpingeal epithelial cells on Matrigel/Millicell, but not in sperm incubated in medium alone or with tracheal cells. Only sperm incubated with oviductal cells developed hyperactivated motility. Scanning electron micrographs revealed that sperm were bound by the rostral portion of the intact acrosome to the apical surface of polarized endosalpingeal cells. These results suggest that the oviduct may not only store sperm but may also maintain sperm viability and fertilizing capacity during the preovulatory period.
Mechanisms of Glucocorticoid Receptor Action in Noninflammatory and Inflammatory Cells (2004)

Glucocorticoids exert profound and diverse physiological effects on a wide range of cell types. Produced and released from the adrenal cortex in response to stress, levels of glucocorticoids are under the control of the hypothalamic–pituitary–adrenal axis. Glucocorticoids participate in numerous physiological processes such as glucose homeostasis; protein, lipid, and carbohydrate metabolism; development; neuorobiology; and programmed cell death. Glucocorticoids exert potent immunosuppressive and antiinflammatory actions in a cell type–specific manner largely through the interruption of cytokine-mediated pathways. These antiinflammatory actions are also complemented by the ability of glucocorticoids to induce apoptosis in many cells including thymocytes, blood monocytes, and peripheral T cells. As a class of drugs, glucocorticoids are among the most widely prescribed in the world for the treatment of immune and inflammatory diseases, including asthma, rheumatoid arthritis, ulcerative colitis, and allergic rhinitis. They are also a component of many chemotherapy regimens for the treatment of leukemias, lymphomas, and myelomas because of their role in the induction of apoptosis. However, long-term use of glucocorticoids has been limited by adverse side effects ranging from suppression of the hypothalamic–pituitary axis and growth retardation to osteoporosis, in addition to the development of glucocorticoid resistance. These undesired side effects of glucocorticoids are hypothesized to occur mainly through activation of gene transcription, whereas the beneficial antiinflammatory effects of glucocorticoids involve mainly mechanisms of gene repression. Understanding the molecular basis of glucocorticoid-induced side effects requires an understanding of their actions on homeostatic signaling processes in all cell types. In this review, we discuss the basic cellular and molecular signaling mechanisms of glucocorticoid action during noninflammatory and inflammatory situations. The Glucocorticoid Receptor
Multiple primary malignancies involving lung cancer (2015)

Colorectal cancer, esophageal cancer, and thyroid cancer were the tumors that most frequently accompanying lung cancer. Metachronous MPM patients showed significantly better OS compared with synchronous MPM patients.
Synthesis and blue phosphorescent device performances of a new bipolar host material containing pyrazino[2,3-b]indole moiety (2014)

Newly designed bipolar host material (<bold>CzPhPz</bold>) consisting of 5<italic>H</italic>-pyrazino[2,3-<italic>b</italic>]indole unit was synthesized and exhibited good electron transport properties with a high triplet energy of 2.83 eV for FIrpic-based blue PHOLEDs.
Engineering of factors determining α‐amylase and cyclodextrin glycosyltransferase specificity in the cyclodextrin glycosyltransferase from <i>Thermoanaerobacterium thermosulfurigenes </i>EM1 (1998)

The starch-degrading enzymes alpha-amylase and cyclodextrin glycosyltransferase (CGTase) are functionally and structurally closely related, with CGTases containing two additional domains (called D and E) compared to the three domains of alpha-amylases (A, B and C). Amino acid residue 196 (Thermoanaerobacterium thermosulfurigenes EM1 CGTase numbering) occupies a dominant position in the active-site cleft. All alpha-amylases studied have a small residue at this position (Gly, Leu, Ser, Thr or Val), in contrast to CGTases which have a more bulky aromatic residue (Tyr or Phe) at this position, which is highly conserved. Characterization of the F196G mutant CGTase of T. thermosulfurigenes EM1 revealed that, for unknown reasons, apart from the F196G mutation, domain E as well as a part of domain D had become deleted [mutant F196G(delta'DE)]. This, nevertheless, did not prevent the purification of a stable and active mutant CGTase protein (62 kDa). The mutant protein was more similar to an alpha-amylase protein in terms of the identity of residue 196, and in the domain structure containing, however, some additional C-terminal structure. The mutant showed a strongly reduced temperature optimum. Due to a frameshift mutation in mutant F196G, a separate protein of 19 kDa with the DE domains was also produced. Mutant F196G(delta'DE) displayed a strongly reduced raw-starch-binding capacity, similar to the situation in most alpha-amylases that lack a raw-starch-binding E domain. Compared to wild-type CGTase, cyclization, coupling and disproportionation activities had become drastically reduced in the mutant F196G(delta'DE), but its saccharifying activity had doubled, reaching the highest level ever reported for a CGTase. Under industrial production process conditions, wild-type CGTase converted starch into 35% cyclodextrins and 11% linear oligosaccharides (glucose, maltose and maltotriose), whereas mutant F196G(delta'DE) converted starch into 21% cyclodextrins and 18% into linear oligosaccharides. These biochemical characteristics indicate a clear shift from CGTase to alpha-amylase specificity.
High-voltage diamond Schottky rectifiers (2005)

In this paper, we simulate and fabricate diamond Schottky rectifiers. The growth rate of pure diamond single crystal epitaxial is from 0.5 up to 100/spl mu/m/hr with boron doping concentration around 1/spl times/1014 cm/sup -3/ to 1/spl times/10/sup 16/ cm/sup -3/. A "liftoff" technology is used to provide the wafer. Theoretical calculation indicates that the diamond Schottky rectifier has a significant lower voltage drop than SiC Schottky rectifier and comparable with SiC PiN diode with the blocking voltage higher than 10 kV. A maximum 50 kHz operating frequency at switching voltage 25 kV is shown based on thermal limit. Vertical structure devices with 70/spl mu/m epi layer achieve 18 A/cm/sup 2/ at 250/spl deg/C at 7 V forward drop as shown with a breakdown voltage of only 600 V. A breakdown voltage of 8 kV at 100/spl mu/m distance is recorded for lateral structure devices without ohmic contact (back to back Schottky diodes), 12.4 kV at 300/spl mu/m distance.
Ionic liquid-based optoelectronic sensor arrays for chemical detection (2014)

Development of ionic liquid (IL)-based colorimetric sensor arrays for detection and identification of chemicals in both the aqueous and vapor phases is reported. These facile and inexpensive optoelectronic sensors were fabricated by using ionic liquids (ILs) derived from readily available pH indicator dyes. A series of 12 different chemosensory ILs were synthesized by pairing anionic pH indicator dyes with trihexyl(tetradecyl)phosphonium ([P66614]) cation via an ion exchange reaction. The incorporation of the [P66614] cation imparted hydrophobic characteristics to these ILs, and this induced hydrophobicity led to their desired low solubility in aqueous solutions, as well as eliminated the need for a specialized hydrophobic matrix/substrate for immobilization. In this manuscript, four different matrices, i.e. glass microfiber filter papers, cotton threads, silica thin layer chromatography (TLC) plates, and alumina TLC plates, were employed for fabrication of sensor arrays. These sensor arrays were used to analyze pH values of aqueous solutions as well as for detection of acidic and basic vapors. To further prove the applicability of these IL sensor arrays as tools to sense closely related complex materials, the arrays were applied to successful discrimination of aqueous solutions of smoke from three commercially available cigarettes. The digital data generated from these sensor arrays were used in developing predictive models for accurately identifying various analytes. Two approaches were used for developing the models, and two methods were applied for assessing the predictive accuracy of the models. Use of cotton threads as a matrix led to development of a more flexible, low volume, and lightweight array to estimate pH and detect a variety of vapors. These wearable arrays may possibly be incorporated into bandages, sweatbands, diapers, and similar systems. Overall, these IL-based sensor arrays should provide a new research direction in the development of advanced colorimetric sensor arrays for detection and identification of a range of analytes relevant to many different applications.
Acute loss of Cell–Cell Communication Caused by G Protein–coupled Receptors: A Critical Role for c-Src (1998)

Gap junctions mediate cell-cell communication in almost all tissues, but little is known about their regulation by physiological stimuli. Using a novel single-electrode technique, together with dye coupling studies, we show that in cells expressing gap junction protein connexin43, cell-cell communication is rapidly disrupted by G protein-coupled receptor agonists, notably lysophosphatidic acid, thrombin, and neuropeptides. In the continuous presence of agonist, junctional communication fully recovers within 1-2 h of receptor stimulation. In contrast, a desensitization-defective G protein-coupled receptor mediates prolonged uncoupling, indicating that recovery of communication is controlled, at least in part, by receptor desensitization. Agonist-induced gap junction closure consistently follows inositol lipid breakdown and membrane depolarization and coincides with Rho-mediated cytoskeletal remodeling. However, we find that gap junction closure is independent of Ca2+, protein kinase C, mitogen-activated protein kinase, or membrane potential, and requires neither Rho nor Ras activation. Gap junction closure is prevented by tyrphostins, by dominant-negative c-Src, and in Src-deficient cells. Thus, G protein-coupled receptors use a Src tyrosine kinase pathway to transiently inhibit connexin43-based cell-cell communication.
Transthoracic application of electrical cardiopulmonary resuscitation for treatment of cardiac arrest (2008)

Optimal skeletal-based and cardiac-based electrical cardiopulmonary resuscitation pulse train parameters generated levels of coronary perfusion pressure significantly greater than ventricular fibrillation and comparable with manual chest compression over a short interval of untreated cardiac arrest.
Rapid Sampling of Acoustic Holograms by Laser-Scanning Techniques (1969)

The paper discusses a technique in which a laser flying spot scanner is used to record an acoustic hologram by reading out the periodic deformations of a solid surface caused by an incident sound field. The technique is compared with the Sokolov tube method and shown to have comparable sensitivity, while not being restricted to low frequencies and small areas. A description is given of experiments using sound frequencies of 2 and 9 MHz, and photographs are presented showing holograms and reconstructions obtained with this technique.
Bismuth(III) <i>n</i>-Hexanoate and Tin(II) 2-Ethylhexanoate Initiated Copolymerizations of ε-Caprolactone and <scp>l</scp>-Lactide (2005)

Using bismuth(III) hexanoate (BiHex3) as initiator and tetraethylene glycol as co-initiator, ε-caprolactone (εCL) and l-lactide (LLA) were copolymerized in bulk. Whereas monomer/initiator and monomer/co-initiator ratios were kept constant, the temperature was varied from 100 to 140 °C. Amorphous copolyesters having a perfectly random sequence were found under all circumstances when BiHex3 was used as initiator. In contrast, parallel experiments with tin(II) 2-ethylhexanoate (SnOct2) as initiator yielded crystalline copolyesters with a blocky sequence. From kinetic measurements of homopolymerizations and from MALDI−TOF spectra of homopolyesters, it was learned that BiHex3 is less efficient as initiator and transesterification catalyst than SnOct2. Therefore, the formation of cycles by “backbiting degradation” is reduced, and the formation of random copolymers involves a special intramolecular transesterification mechanism. These results and the extremely low toxicity of Bi salts render BiHex3 a particular useful initiator for biomedical applications of polylactones.
[The morphous analyses of three different characteristics cells growing in soft agar.]. (2008)

Soft agar assay is a good method in evaluating and observed biological property of mammalian cells according to their phenotypes.
An idiotope--anti-idiotope complex and the structuralbasis of molecular mimicking. (1994)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Unlocking COVID therapeutic targets: A structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike (2020)

There are no approved target therapeutics against SARS-CoV-2 or other beta-CoVs. The beta-CoV Spike protein is a promising target considering the critical role in viral infection and pathogenesis and its surface exposed features. We performed a structure-based strategy targeting highly conserved druggable regions resulting from a comprehensive large-scale sequence analysis and structural characterization of Spike domains across SARSr- and MERSr-CoVs. We have disclosed 28 main consensus druggable pockets within the Spike. The RBD and SD1 (S1 subunit); and the CR, HR1 and CH (S2 subunit) represent the most promising conserved druggable regions. Additionally, we have identified 181 new potential hot spot residues for the hSARSr-CoVs and 72 new hot spot residues for the SARSr- and MERSr-CoVs, which have not been described before in the literature. These sites/residues exhibit advantageous structural features for targeted molecular and pharmacological modulation. This study establishes the Spike as a promising anti-CoV target using an approach with a potential higher resilience to resistance development and directed to a broad spectrum of Beta-CoVs, including the new SARS-CoV-2 responsible for COVID-19. This research also provides a structure-based rationale for the design and discovery of chemical inhibitors, antibodies or other therapeutic modalities successfully targeting the Beta-CoV Spike protein.