gebhart/patrepeval huggingface dataset:
An Approach to Cross-Lingual Voice Conversion (2019)

The most prevalent multilingual Text-to-Speech (TTS) synthesis systems encounter an unnatural speaker shift at the language boundaries. This is observed when they are employed for code-mixed TTS synthesis. For the very fact that the collection of polyglot speech is non-trivial, many alternative approaches have been in focus. Cross-Lingual Voice Conversion (CLVC) has been one of those to generate speech with desired speaker and language identities. Our aim in this paper is to design a light-weighted CLVC framework between a pair of Mandarin-English speakers. CLVC is challenging when compared to traditional Voice Conversion (VC) because of its nature of accommodating unaligned corpus from the source and target speakers. We thus focus on generating a parallel corpus for CLVC and bridging the gap between speakers and languages. We perform a text-independent voice conversion with a three-layered conventional Neural Network (NN) for this purpose. The main contributions include i) Source similarity in both training and conversion stages of CLVC, ii) generation of a parallel corpus and iii) text independent and transcription free CLVC. We exploit two variants of a Neural Network in the proposed framework, i) an autoencoder to enable the source similarity and generation of parallel corpus, ii) a traditional DNN for feature mapping between the source and target. The subjective and objective evaluations show that the proposed method is indeed capable of performing a CLVC with an auto-encoded speech.
Monitoring Animal Behaviour and Environmental Interactions Using Wireless Sensor Networks, GPS Collars and Satellite Remote Sensing (2009)

Remote monitoring of animal behaviour in the environment can assist in managing both the animal and its environmental impact. GPS collars which record animal locations with high temporal frequency allow researchers to monitor both animal behaviour and interactions with the environment. These ground-based sensors can be combined with remotely-sensed satellite images to understand animal-landscape interactions. The key to combining these technologies is communication methods such as wireless sensor networks (WSNs). We explore this concept using a case-study from an extensive cattle enterprise in northern Australia and demonstrate the potential for combining GPS collars and satellite images in a WSN to monitor behavioural preferences and social behaviour of cattle.
Online control of simulated humanoids using particle belief propagation (2015)

We present a novel, general-purpose Model-Predictive Control (MPC) algorithm that we call Control Particle Belief Propagation (C-PBP). C-PBP combines multimodal, gradient-free sampling and a Markov Random Field factorization to effectively perform simultaneous path finding and smoothing in high-dimensional spaces. We demonstrate the method in online synthesis of interactive and physically valid humanoid movements, including balancing, recovery from both small and extreme disturbances, reaching, balancing on a ball, juggling a ball, and fully steerable locomotion in an environment with obstacles. Such a large repertoire of movements has not been demonstrated before at interactive frame rates, especially considering that all our movement emerges from simple cost functions. Furthermore, we abstain from using any precomputation to train a control policy offline, reference data such as motion capture clips, or state machines that break the movements down into more manageable subtasks. Operating under these conditions enables rapid and convenient iteration when designing the cost functions.
Splenic adherent cells, stimulated in vitro, induce the reactive formation of lymphoid follicles and germinal centres in draining lymph nodes after subcutaneous transfusion into syngeneic mice (1998)

The reactive formation of lymphoid follicles and germinal centres in lymph nodes, induced by subcutaneous transfer of in vitro activated splenic adherent cells into syngeneic mice, were studied. Adherent cells were obtained by incubating spleen cell suspensions for 24 h and activated by incubating for 1 h in the medium containing keyhole limpet haemocyanin (KLH) absorbed onto alumina. Some of the treated adherent cells were irradiated with 10 Gy x-rays, while others were either not stimulated or were stimulated with alumina-KLH but killed by repeated freezing and thawing. Examination of adherent cell smears immunostained with antibodies against, F4/80, Mac-1, Mac-2 and NLDC-145 indicated that many adherent cells displayed macrophage markers but few displayed the interdigitating cell marker. Animals transfused with KLH-treated adherent cells with or without irradiation showed a marked increase in the number of lymphoid follicles and germinal centres in draining lymph nodes, whereas those transfused with adherent cells which had not been KLH-treated or which had been killed after KLH treatment displayed no significant change in the number of follicles. These results were interpreted as indicating that following transfusion, antigen-activated adherent macrophages migrated into the draining lymph nodes and induced the reactive formation of lymphoid follicles and germinal centres outside preexisting follicles.
An adenosine A<sub>2A</sub> receptor agonist reduces interleukin‐8 expression and glycosaminoglycan loss following septic arthrosis (2005)

The purpose of this study was to determine whether an adenosine A(2A) receptor agonist (ATL146e) might augment the current treatment regimen of antibiotics plus irrigation and debridement to prevent the arthritic effects associated with joint sepsis. Staphylococcus aureus bacteria were injected into knees of rabbits, which were divided into 4 treatment groups (12 rabbits per group): no treatment, ATL146e only, antibiotics only, or antibiotics plus ATL146e. Analysis at days 1, 3, and 7 consisted of gross joint appearance, synovial fluid, serum, histologic, immunohistochemical, and biochemical analysis. Synovial fluid cultures at day 7 were negative in all antibiotic and antibiotic plus ATL146e treated knees indicating clearance of bacteria. Average WBC counts from synovial fluid aspirates significantly decreased with treatment of antibiotics alone and antibiotics plus ATL146e. Treatment with antibiotics plus ATL146e significantly decreased the Interleukin-8 content when compared to other treatment groups (p<0.001) indicating inflammatory response suppression. Histologic grading resulted in notably improved scores in the antibiotics plus ATL146e group compared to other treatment groups (p < or =0.001). Glycosaminoglycan assay values were significantly greater in the ATL146e plus antibiotics group compared to the untreated control group (p<0.04) indicating chondroprotection. The results of this study indicate that administration of an adenosine A(2A) agonist in combination with antibiotic therapy diminishes joint WBC chemotaxis and reduces joint inflammation, while not compromising the clearance of intraarticular bacteria in a rabbit model. Early bacterial clearance with modulation of the inflammatory response appears to prevent the early degradative effects of joint sepsis.
Detailed Anatomical and Electrophysiological Models of Human Atria and Torso for the Simulation of Atrial Activation (2015)

Atrial arrhythmias, and specifically atrial fibrillation (AF), induce rapid and irregular activation patterns that appear on the torso surface as abnormal P-waves in electrocardiograms and body surface potential maps (BSPM). In recent years both P-waves and the BSPM have been used to identify the mechanisms underlying AF, such as localizing ectopic foci or high-frequency rotors. However, the relationship between the activation of the different areas of the atria and the characteristics of the BSPM and P-wave signals are still far from being completely understood. In this work we developed a multi-scale framework, which combines a highly-detailed 3D atrial model and a torso model to study the relationship between atrial activation and surface signals in sinus rhythm. Using this multi scale model, it was revealed that the best places for recording P-waves are the frontal upper right and the frontal and rear left quadrants of the torso. Our results also suggest that only nine regions (of the twenty-one structures in which the atrial surface was divided) make a significant contribution to the BSPM and determine the main P-wave characteristics.
Involvement of the nuclear orphan receptor NURR1 in the regulation of corticotropin-releasing hormone expression and actions in human inflammatory arthritis (2001)

These data demonstrate the involvement of the transcription factor NURR1 in the regulation of CRH expression and activity in human inflammatory arthritis.
Real-time estimation of roll angle and CG height for active rollover prevention applications (2009)

Roll angle and height of the center of gravity are important variables that play a critical role in the calculation of real-time rollover index for a vehicle. The rollover index predicts the real-time propensity for rollover and is used in activation of rollover prevention systems such as differential braking based stability control systems. Sensors to measure roll angle are expensive. Sensors to estimate the c.g. height of a vehicle do not exist. While the height of the center-of-gravity does not change in real-time, it does change with the number of passengers and loading of the vehicle. This paper focuses on algorithms to estimate roll angle and c.g. height. The algorithms investigated include a sensor fusion algorithm that utilizes a low frequency tilt angle sensor and a gyroscope and a dynamic observer that utilizes only a lateral accelerometer and a gyroscope. The performance of the developed algorithms is investigated using simulations and experimental tests. Experimental data confirm that the developed algorithms perform reliably in a number of different maneuvers that include constant steering, ramp steering, double lane change and sine with dwell steering tests.
Polymorphic admixture typing in human ethnic populations. (1994)

A panel of 257 RFLP loci was selected on the basis of high heterozygosity in Caucasian DNA surveys and equivalent spacing throughout the human genome. Probes from each locus were used in a Southern blot survey of allele frequency distribution for four human ethnic groups: Caucasian, African American, Asian (Chinese), and American Indian (Cheyenne). Nearly all RFLP loci were polymorphic in each group, albeit with a broad range of differing allele frequencies (delta). The distribution of frequency differences (delta values) was used for three purposes: (1) to provide estimates for genetic distance (differentiation) among these ethnic groups, (2) to revisit with a large data set the proportion of human genetic variation attributable to differentiation within ethnic groups, and (3) to identify loci with high delta values between recently admixed populations of use in mapping by admixture linkage disequilibrium (MALD). Although most markers display significant allele frequency differences between ethnic groups, the overall genetic distances between ethnic groups were small (.066-.098), and < 10% of the measured overall molecular genetic diversity in these human samples can be attributed to "racial" differentiation. The median delta values for pairwise comparisons between groups fell between .15 and .20, permitting identification of highly informative RFLP loci for MALD disease association studies.
IFN‐α<sub>1</sub> gene transfection completely abolishes the tumorigenicity of murine B16 melanoma cells in allogeneic DBA/2 mice and decreases their tumorigenicity in syngeneic C57BL/6 mice (1995)

The murine B16 melanoma (H-2b) was transfected with a retroviral vector containing the mouse IFN-alpha 1 gene. IFN-alpha 1-transfected cells produced IFN-alpha in vitro and exhibited an altered phenotype characterized by a decreased rate of multiplication, enhanced expression of H-2 antigens, an antiviral state to VSV, and decreased pigmentation. Control and IFN-alpha 1-transfected cells were tested for their ability to grow in syngeneic (H-2b) C57Bl/6 and allogeneic (H-2d) DBA/2 mice. IFN-alpha 1-producing B16 clones were less tumorigenic after s.c., i.p., and i.v. routes of injection than IFN-non-producer B16 clones in syngeneic C57Bl/6 mice. IFN-alpha 1-producing B16 cells were, however, totally rejected by allogeneic DBA/2 mice regardless of the routes and inocula tested, while control B16 cells grew in and killed DBA/2 mice. The total rejection of IFN-alpha 1-transfected B16 cells in allogeneic mice appeared to be dependent on T cells as these cells grew in DBA/2 nude mice. Incubation of IFN-alpha-producing clones with anti-mouse IFN-alpha/beta prior to injection into C57Bl/6 mice did not enhance their tumorigenicity. Likewise, injection of C57Bl/6 and DBA/2 mice with antibody to IFN-alpha/beta did not enhance the tumorigenicity of IFN-alpha 1-transfected cells. C57Bl/6 mice immunized with irradiated IFN-alpha 1 cells were only slightly protected against a subsequent challenge with parental B16 cells. In contrast, DBA/2 mice immunized with irradiated IFN-alpha 1 cells exhibited tumor-specific, long-lasting immunity to subsequent challenge with parental B16 cells.
Structural and Electrochemical Studies of Rhombohedral Na<sub>2</sub>TiM(PO<sub>4</sub>)<sub>3</sub> and Li<sub>1.6</sub>Na<sub>0.4</sub>TiM(PO<sub>4</sub>)<sub>3</sub> (M = Fe, Cr) Phosphates (2003)

The crystal structures of NASICON compositions Z2TiM(PO4)3 (Z = Na, Li; M = Cr, Fe) were investigated through powder neutron diffraction on the beam lines D1A (λ = 1.9104 Å) and D2B (λ = 1.5924 Å) at ILL, Grenoble, France. Na2TiCr(PO4)3 and Na2TiFe(PO4)3 are isostructural. They crystallize in the space group R3̄c, with the sodium ions being located in the M1 (τ ∼ 1) and M2 sites (τ ∼ 1/3). NASICON Li1.6Na0.4TiCr(PO4)3 and Li1.6Na0.4TiFe(PO4)3 were prepared through ion exchange from the sodium analogues. They crystallize in the space group R3̄, with the lithium ions being located in the M3 tetrahedral site. The remaining, unexchanged, sodium ions are still located on the M1 site. Electrochemical insertion of sodium or lithium into these structures was followed through slow intermittent titration techniques coupled with in situ X-ray diffraction. We show that for both Na2+xTiM(PO4)3 and Li1.6+xNa0.4TiM(PO4)3 (0 ≤ x ≤ 1 for M = Cr, 0 ≤ x ≤ 2 for M = Fe), the insertion proceeds through a single-phase mechanism.
Chemoenzymatic synthesis, structural study and biological activity of novel indolizidine and quinolizidine iminocyclitols (2012)

The synthesis, conformational study and inhibitory properties of diverse indolizidine and quinolizidine iminocyclitols are described. The compounds were chemo-enzymatically synthesized by two-step aldol addition and reductive amination reactions. The aldol addition of dihydroxyacetone phosphate (DHAP) to N-Cbz-piperidine carbaldehyde derivatives catalyzed by L-rhamnulose 1-phosphate aldolase from Escherichia coli provides the key intermediates. The stereochemical outcome of both aldol addition and reductive amination depended upon the structure of the starting material and intermediates. The combination of both reactions furnished five indolizidine and six quinolizidine type iminocyclitols. A structural analysis by NMR and in silico density functional theory (DFT) calculations allowed us to determine the population of stereoisomers with the trans or cis ring fusion, as a consequence of the inversion of configuration of the bridgehead nitrogen. The trans fusion was by far the most stable, but for certain stereochemical configurations of the 3-hydroxymethyl and hydroxyl substituents both trans and cis fusion stereoisomers coexisted in different proportions. Some of the polyhydroxylated indolizidines and quinolizidines were shown to be moderate to good inhibitors against α-L-rhamnosidase from Penicillium decumbens. Indolizidines were found to be moderate inhibitors of the rat intestinal sucrase and of the exoglucosidase amyloglucosidase from Aspergillus niger. In spite of their activity against α-L-rhamnosidase, all the compounds were ineffective to inhibit the growth of the Mycobacterium tuberculosis, the causative agent of tuberculosis.
Inhibition of α5 γ-Aminobutyric Acid Type A Receptors Restores Recognition Memory After General Anesthesia (2012)

Inhalational anesthetics cause deficits in anterograde recognition memory. This proof-of-concept study shows that α5GABA(A) receptors are necessary for the development of postanesthetic deficits in recognition memory and that these receptors can be targeted to restore memory even after the anesthetic has been eliminated.
Modelling of cracks on different scales in ferroelectric materials (2011)

Abstract In this work we study contributions to the effective fracture toughness of ferroelectric materials arising from effects on macroscopic and mesoscopic scales of the system. On the macroscopic scale, the crack in a ferroelectric material is modeled taking into account an extended theory of stresses at interfaces in dielectric solids [1‐3]. We predict several new effects, such as the “poling effect”, “collinear effect” and the coupling of a Mode‐II shear loading and the Mode‐I SIF. Further, on the mesoscopic scale, we study the influence of polarization switching limited to the fracture process zone (small scale switching) on the fracture toughness. (© 2011 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Modeling and Interpretation of Scattering Mechanisms in Polarimetric Synthetic Aperture Radar: Advances and perspectives (2014)

Recent advances in scattering modeling and model-based decomposition theorem were reviewed. The notable achievements include orientation compensation processing, nonnegative eigenvalue constraint, generalized scattering models, complete information utilization, full-parameter inversion strategy, and the polarimetric-interferometric decomposition scheme. These advances contribute to make scattering models more adaptive, better fit observations and guarantee physically meaningful decomposition solutions. The key features of these advances have been summarized. Performance evaluation and further development perspectives were also discussed. One promising way is to fuse multiple data to better model scattering mechanisms, such as the polarimetric-interferometric modeling attempts. Besides, with the progress in PolSAR sensors, imaging modes (e.g., bistatic, hybrid-polarization and multi-incident-angle modes) and application requirements, the development of specific scattering mechanism interpretation techniques, multiangular decomposition, and compact/hybrid decomposition techniques are also highly preferred.
GeoTime Information Visualization (2005)

Analyzing observations over time and geography is a common task but typically requires multiple, separate tools. The objective of our research has been to develop a method to visualize, and work with, the spatial interconnectedness of information over time and geography within a single, highly interactive 3D view. A novel visualization technique for displaying and tracking events, objects and activities within a combined temporal and geospatial display has been developed. This technique has been implemented as a demonstratable prototype called GeoTime in order to determine potential utility. Initial evaluations have been with military users. However, we believe the concept is applicable to a variety of government and business analysis tasks
Anticoagulant therapy in acute lung injury (2003)

In the lung, alveolar and interstitial fibrin deposition are the hallmarks of early phase ALI. Local procoagulant activity and reduced fibrinolysis constitute the rationale for anticoagulant use in the treatment of ALI. An activated complex of tissue factor and factor VIIa triggers procoagulant activity in the lung, with subsequent thrombin formation and fibrin deposition. Increased pulmonary vascular permeability and leukocyte accumulation have been successfully prevented in animals treated with tissue factor/activated factor VII pathway inhibitor. In humans, a phase II study evaluating tissue factor pathway inhibitor in the treatment of severe sepsis suggested that lung function in acute respiratory distress syndrome patients was improved. However, the phase III trial failed to demonstrate a survival benefit; data regarding respiratory dysfunction have not yet been published. Heparin, despite effectively inhibiting thrombin formation, has not shown consistent benefits in reducing lung injury, and its efficacy has not yet been evaluated in a controlled study. Antithrombin administration in animals has shown consistent benefits with ALI, but clinical studies have failed to demonstrate reductions in mortality and lung injury. Activated protein C administration has been shown to improve survival and lung function in both animal and clinical studies. Soluble thrombomodulin has been shown to improve ALI in animals, and it is currently being evaluated in humans with sepsis. Finally, plasminogen activators may improve gas exchange in ALI, but studies in humans are limited.
Formation of vesicles and microemulsions in a water/tetraethylene glycol dodecyl ether/dodecane system (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of vesicles and microemulsions in a water/tetraethylene glycol dodecyl ether/dodecane systemHironobu Kunieda, Kazuyoshi Nakamura, H. T. Davis, and D. Fennell EvansCite this: Langmuir 1991, 7, 9, 1915–1919Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/la00057a016https://doi.org/10.1021/la00057a016research-articleACS PublicationsRequest reuse permissionsArticle Views308Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Acquired Immunodeficiency Syndrome in African Patients (1984)

Between May 1979 and April 1983, 18 previously healthy African patients were hospitalized in Belgium with opportunistic infections (cryptococcosis, Pneumocystis carinii pneumonia, central-nervous-system toxoplasmosis, progressive cutaneous herpes simplex virus infection, disseminated cytomegalovirus infection, candidiasis, or cryptosporidiosis) or Kaposi's sarcoma, or with both. Ten of them died. During the same period five other patients were hospitalized with an illness consistent with a prodrome of the acquired immunodeficiency syndrome (chronic lymphadenopathy, fever, weight loss, and diarrhea). All patients tested had a marked decrease in helper T cells; an inversion of the normal ratio of helper to suppressor T cells, and a decreased or absent blastogenic response of lymphocytes to mitogens. Twenty patients had anergy. There was no evidence of an underlying immunosuppressive disease and no history of blood-product transfusion, homosexuality, or intravenous-drug abuse. This syndrome in patients originating in Central Africa is similar to the acquired immunodeficiency syndrome reported in American patients.