gebhart/patrepeval huggingface dataset:
A Potential Blood Substitute from A Tetronic Polyol and A Modified Hemoglobin (1992)

This investigation reports a new potential blood substitute. An acellular fluid is formed between a Tetronic polyol and a modified hemoglobin. It was possible to stabilize the hemoglobin with glutaric acid. The subsequent reaction with the alcohols of the Tetronic polyol resulted in a useful resuscitative fluid. Exchange transfusion experiments in rats was possible at the 75% replacement level with an excellent survival rate. This was apparently possible because of the effective transport properties of this material. Histological sections of the liver, kidney and lungs showed little or no permanent damage to the organs. The Tetronic polyol - modified hemoglobin complex was not excreted in the urine in contrast to the modified hemoglobin by itself and a solution of unmodified hemoglobin. These preliminary studies indicate that this combination of a polymer and modified hemoglobin has a potential use as a red cell substitute.
Development of male contraceptive vaccine - a perspective (1997)

This paper reviews the recent advances that have occurred in the area of development of a male contraceptive vaccine. The vaccine candidates considered for review are hormone/hormone receptor-based proteins including luteinizing hormone-releasing hormone (LHRH)/LH, follicle stimulating hormone (FSH), as well as LH and FSH receptor proteins. The review also highlights the advances in our basic understanding of gonadotrophin action which have led to development of these vaccines. Focus is mainly on studies in the non-human primate which may be directly relevant to projected studies in the human. The data indicate that the vaccines are well tolerated by the primate (including the human based on limited data) and do not give rise to any known toxic symptoms or immediate health hazards. The response to the immunogen has been uniform and it may be possible to increase antibody titres as well as prolong the immune response by adding acceptable immune stimulators to the adjuvant cocktail and developing better immunization schedules or immunogen delivery systems. Contraceptive vaccines for the male are a feasible proposition and attention should now be focussed on evaluating carefully the bioefficacy of antibodies raised to recombinant ovine FSHbeta or FSH receptor protein fragments in both human and non-human primates. The advantage of the FSH/FSH receptor over the LHRH/LH-based vaccine lies in the fact that the former does not require an exogenous testosterone supplement to maintain accessory gland function, libido etc. The LHRH/LH-based vaccine results in azoospermia, while the FSH vaccine causes the production of low numbers of poor quality spermatozoa which are incapable of impregnating cycling females.
Large Area Tunable Alvarez Metalens via Stepper Photolithography (2018)

Using inexpensive and high-throughput stepper lithography, we design and fabricate 1 cm wide tunable metalenses which exhibit a focal length change of 162%, more than 6 cm, with only 2.4 mm lateral actuation.
Theory and application of exchange-driven switching (2005)

Summary form only given. The complete presentation was not made available for publication as part of the conference proceedings.
Isolation and mapping of a polymorphic DNA sequence (pEFD64.1) on chromosome 3 [D3S42] (1988)

A 5.2 kb TaqI fragment of cosmid EFD64 isolated by a HBV-3 oligonucleotide (1) was subcloned into AccI site of pUC18.
Vaccination prevents<i>Helicobacter pylori</i>-induced alterations of the gastric flora in mice (2006)

Molecular analysis of the gastric microflora in mice revealed that Helicobacter pylori infection causes an increase in microbial diversity. The stomachs of H. pylori-infected animals were colonized by bacteria which are naturally restricted to the lower intestinal tract. Clostridia, Bacteroides/Prevotella spp., Eubacterium spp., Ruminococcus spp., streptococci and Escherichia coli were detected exclusively in the stomachs of infected animals, whereas lactobacilli dominated the gastric flora in noninfected mice. The H. pylori-induced shifts in the gastric microbiota were independent from histological pathology and from changes in the gastric pH but were prevented by immunization of mice with live Salmonella expressing H. pylori urease. Immunized mice displayed reduced H. pylori levels in the gastric epithelium and developed a normal gastric microflora, indicating that vaccination may be protective against H. pylori-induced changes in the gastric flora.
A time-frequency approach for newborn seizure detection (2001)

Techniques previously designed for seizure detection in newborns using the electroencephalogram (EEG) have been relatively inefficient due to their assumption of local stationarity of the EEG. To overcome the problem raised by the nonstationarity of the EEG signal, current methods are extended to a time-frequency approach. This allows the analysis and characterization of the different newborn EEG patterns that are intended to be the first step toward an automatic time-frequency seizure detection and classification. An in-depth analysis of both the autocorrelation and spectrum seizure detection techniques identified the detection criteria that can be extended to the time-frequency domain. The selected method uses a high-resolution reduced interference time-frequency distribution referred to as the B-distribution (BD). Here, the authors present the various patterns of observed time-frequency seizure signals and relate them to current knowledge of seizures. In particular, initial results indicate that a quasilinear instantaneous frequency (IF) can be used as a critical feature of the EEG seizure characteristics.
A structure for adaptive order statistics filtering (1994)

In applications such as smoothing and enhancement of images, adaptive filtering techniques offer the flexibility needed for good performance with non-stationary observations. Many adaptive schemes can be based on the idea of determining the local statistics of the signal through appropriate tests on the data, to aid in the selection of a filtering procedure that is suited to the data. In the paper, the authors consider decision-directed or data-dependent adaptive filtering schemes that are based on order statistics. A general formulation for such a class of adaptive order statistics filters is presented. Approximate statistical performance analysis, especially in the presence of edges, may be carried out for this entire class of filters. The authors give examples of some existing filters that fit into this framework. The formulation also accommodates filters that employ multiple windows in their operation. To illustrate the potential of this class of multiple window (MW) filters, they construct and analyze simple filters, like the triple window median (TW-MED) and the triple window median of means (TW-MOM) filters, that are shown to yield useful performance. The class of mean-median hybrid (MMH) filters is also presented as a simple example which may be extended to give interesting performance.
A Broadband Vertical Transition for Millimeter-Wave Applications (2008)

This paper reports on a broadband vertical transition, which shows superior characteristics from DC up to 85 GHz. The design and analysis of the novel transition are presented. The proposed transition is practicable in low cost substrates and requires only three vias, which ensures compact and easy realization. Further, the usefulness of this transition as a 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> -level interconnection for multilayer modules with excellent robustness against lateral misalignment is presented. The measurement results of back-to-back arrangements exhibit good performances up to 60 GHz and show reasonable agreement with simulation.
Expression of dopamine transporter at the tips of growing neurites of PC12 cells. (1996)

The four kinds of oligopeptides specific in amino acid sequence to a rat dopamine transporter (DAT), peptide-1-peptide-4, were chemically synthethized. An attempt to produce antipeptide antibodies against these oligopeptides was made with an in vitro immunization method. Two monoclonal antibodies, MAbs H-1a and H-1b, were produced against one of the oligopeptides, peptide-1. Western blot analysis confirmed that the two antibodies recognized an approximately 85,000 Da protein in a synaptosomal fraction prepared from the rat striatum but none in the fraction from the cerebellum. The specificity of the antibody to DAT was also confirmed by an antibody absorption test using two synthetic oligopeptides, one of which is specific only to DAT. These results have confirmed the specificity of the present antibody to DAT. The expression and subcellular localization of DAT were immunohistochemically examined with MAbs H-1a and H-1b in PC12 cells treated with nerve growth factor (NGF). The antibody labeled the surface of PC12 cells. When the cells were treated with NGF, the expression of DAT was significantly emphasized, first in the area mainly including the Golgi apparatus and rough endoplasmic reticulum and then on the surface of growth cones from the beginning of neurite outgrowth. DAT was detected by Western blot analysis in a microsomal fraction prepared from PC12 cells. The activity of DAT in the PC12 cells was pharmacologically confirmed by the uptake of [3H]-dopamine and blockade by uptake inhibitors. The NGF treatment doubled the dopamine uptake activity. GBR12909, a specific inhibitor of DAT, blocked the [3H]-dopamine at a concentration of 10(-7) M. The expression of DAT and norepinephrine transporter (NET) mRNA in the PC12 cells was examined by reverse transcriptase-polymerase chain reaction (RT-PCR). DAT mRNA significantly increased in the NGF-treated cells after 7 days of incubation, whereas NET mRNA markedly decreased.
Functional Selection of Synthetic Lubricants (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFunctional Selection of Synthetic LubricantsR. G. Larsen and A. BondiCite this: Ind. Eng. Chem. 1950, 42, 12, 2421–2427Publication Date (Print):December 1, 1950Publication History Published online1 May 2002Published inissue 1 December 1950https://pubs.acs.org/doi/10.1021/ie50492a017https://doi.org/10.1021/ie50492a017research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
All-optical storage of a 1.25 kb packet at 10 Gb/s (1995)

An all-optical pulse storage ring storing a 1.25 kb packet at 10 Gb/s is demonstrated. Optical modulation of the transmission of a semiconductor diode amplifier via cross-gain saturation provides timing stability in the ring.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Autoridad y violencia en el Antiguo Testamento: los relatos de Caín y Abel, y de Judit / Authority and violence in the Old Testament: The stories of Cain and Abel, and Judith (2017)

The Old Testament narratives in which human violence appears as a subject will not only help to better understand the moral norms and the legal code of the people of Israel, but also to discover those principles that lead to God, as real authority, to condemn or to accept.
A New Safety and Stability Enhanced Riser Control System: An Integrated Hybrid Riser Tensioning System (2012)

This paper presents the framework for a novel riser tensioning system using a hybrid arrangement for energy management. This hybrid tensioning system, which integrates electrical tensioners and energy storage elements with existing hydro-pneumatic tensioners, is designed to enhance the safety of a deepwater riser system by improving stability and dynamic performance. Four control modes are investigated for the framework implementation: 1. Normal operation mode for active heave compensation. 2. Riser-recoil mode to control recoil on sudden release and minimize unwanted riser upward movement. 3. VIV suppression mode to reduce disturbances induced by ocean currents in the riser string and to extend riser fatigue life. 4. Reconnection mode provides control to allow reconnecting the LMRP to the BOP without using the drawworks, freeing the drawworks from the time consuming procedure of landing the LMRP and tensioning the riser. A replacement strategy is proposed so that one can update any existing system to the hybrid riser tensioning system by replacing certain pairs of hydro-pneumatic tensioners with the novel electrical riser tensioners to achieve smooth system upgrade and better system reliability.
Design and Implementation of an Impulse Commutated Solid-State Transfer Switch (2006)

In recent years, voltage sags have become a very important power quality issue. Voltage sags often interrupt manufacturing processes and result in significant losses. To improve the quality and reliability of electric power, more and more utility companies provide dual power feeders to high-tech manufacturers. The solid-state transfer switch (STS) based on thyristors can utilize the dual power feeders to protect sensitive loads against voltage sags. Conventional STS may require more than a quarter cycle to complete the transfer process depending on the operating condition of its loads. In this paper, an improved STS with resonant impulse commutation circuit is proposed. The proposed system can greatly reduce the transfer time and provide better protection against voltage sags. Laboratory test results are presented to validate the performance of the proposed STS system.
Enzyme System for Methanol Oxidation in Yeasts (1974)

Enzyme System for Methanol Oxidation in Yeasts Get access Nobuo Kato, Nobuo Kato Department of Agricultural Chemistry, Kyoto University, Kyoto Search for other works by this author on: Oxford Academic Google Scholar Yoshiki Tani, Yoshiki Tani Department of Agricultural Chemistry, Kyoto University, Kyoto Search for other works by this author on: Oxford Academic Google Scholar Koichi Ogata Koichi Ogata Department of Agricultural Chemistry, Kyoto University, Kyoto Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 38, Issue 3, 1 March 1974, Pages 675–677, https://doi.org/10.1080/00021369.1974.10861214 Published: 01 March 1974 Article history Received: 02 October 1973 Published: 01 March 1974
Genomic Analyses Reveal Broad Impact of miR-137 on Genes Associated with Malignant Transformation and Neuronal Differentiation in Glioblastoma Cells (2014)

miR-137 plays critical roles in the nervous system and tumor development; an increase in its expression is required for neuronal differentiation while its reduction is implicated in gliomagenesis. To evaluate the potential of miR-137 in glioblastoma therapy, we conducted genome-wide target mapping in glioblastoma cells by measuring the level of association between PABP and mRNAs in cells transfected with miR-137 mimics vs. controls via RIPSeq. Impact on mRNA levels was also measured by RNASeq. By combining the results of both experimental approaches, 1468 genes were found to be negatively impacted by miR-137--among them, 595 (40%) contain miR-137 predicted sites. The most relevant targets include oncogenic proteins and key players in neurogenesis like c-KIT, YBX1, AKT2, CDC42, CDK6 and TGFβ2. Interestingly, we observed that several identified miR-137 targets are also predicted to be regulated by miR-124, miR-128 and miR-7, which are equally implicated in neuronal differentiation and gliomagenesis. We suggest that the concomitant increase of these four miRNAs in neuronal stem cells or their repression in tumor cells could produce a robust regulatory effect with major consequences to neuronal differentiation and tumorigenesis.
An LP-based blind model for restoring bone-conducted speech (2008)

Due to the stability against the external noise, bone-conducted (BC) speech seems better to be used instead of noisy air-conducted speech in an extremely noisy environment. However the quality of bone-conducted speech is very low and restoring bone-conducted speech is a challenged topic in speech signal processing field. As the main issue to improve the BC speech, many studies try to model and resolve the degradation when the signal is conducted through bone transduction. In previous study, we proposed a linear prediction (LP) based blind-restoration model. In this paper, we therefore completely evaluated the proposed model in comparison with other models to find out whether our proposed model could adequately improve voice quality and the intelligibility of BC speech, using objective measures (LSD, MCD, and LCD) and carrying out Japanese word-intelligibility tests (JWITs), Vietnamese word-intelligibility tests (VWITs) and Modified Rhyme Tests (MRTs) for English. The results of experiments on different languages, i.e. Japanese, English and Vietnamese proved the practicability of blind-BC restoration.
Panto time…oh yes it is! (2013)

Take children to watch a seasonal pantomime for a fun way to enjoy the spectacle and magic of theatre and see humorous twists on stories they know, says Viv Hampshire. With no danger of getting shushed!
Ligand-mediated Activation of the cAMP-responsive Guanine Nucleotide Exchange Factor Epac (2003)

Epac is a cAMP-dependent exchange factor for the small GTP-binding protein Rap. The activity of Epac is inhibited by a direct interaction between the C-terminal helical part of the cAMP-binding domain, called the lid, and the catalytic region, which is released after binding of cAMP. Herein, we show that the activation properties are very sensitive to modifications of the cyclic nucleotide. Some analogues are inhibitory and others are stimulatory; some are characterized by a much higher activation potential than normal cAMP. Mutational analysis of Epac allows insights into a network of interactions between the cyclic nucleotides and Epac. Mutations in the lid region are able to amplify or to attenuate selectively the activation potency of cAMP analogues. The properties of cAMP analogues previously used for the activation of the cAMP responsive protein kinase A and of 8-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclicmonophosphate, an analogue highly selective for activation of Epac were investigated in detail.
Soleilmavis case summary on mind control torture and abuse (2012)

One of the twenty-first century’s greatest violations of human rights is the proliferation of mind control technologies and their accompanying abuse and torture. The author, Soleilmavis Liu, is one of thousands of innocent victims across the globe, who has become an activist for their freedom. Mind control technologies are weapons which use electromagnetic waves to hijack a person’s brain and nervous system and subvert an individual's sense of control over their own thinking, behaviour, emotions or decision making. This article is a brief introduction to these technologies and one of its victims, Soleilmavis Liu. Soleilmavis’ work is to expose mind control technologies and their torturous abuses and to urge governments worldwide to investigate and halt these egregious violations of human rights.

	 

	Key words: Mind control technology, directed energy weapons, human rights, torture, abuse.
Molecular Details of Bax Activation, Oligomerization, and Membrane Insertion (2009)

Bax and Bid are pro-apoptotic members of the Bcl-2 protein family. Upon cleavage by caspase-8, Bid activates Bax. Activated Bax inserts into the mitochondrial outer membrane forming oligomers which lead to membrane poration, release of cytochrome c, and apoptosis. The detailed mechanism of Bax activation and the topology and composition of the oligomers are still under debate. Here molecular details of Bax activation and oligomerization were obtained by application of several biophysical techniques, including atomic force microscopy, cryoelectron microscopy, and particularly electron paramagnetic resonance (EPR) spectroscopy performed on spin-labeled Bax. Incubation with detergents, reconstitution, and Bid-triggered insertion into liposomes were found to be effective in inducing Bax oligomerization. Bid was shown to activate Bax independently of the stoichiometric ratio, suggesting that Bid has a catalytic function and that the interaction with Bax is transient. The formation of a stable dimerization interface involving two Bcl-2 homology 3 (BH3) domains was found to be the nucleation event for Bax homo-oligomerization. Based on intermolecular distance determined by EPR, a model of six adjacent Bax molecules in the oligomer is presented where the hydrophobic hairpins (helices alpha5 and alpha6) are equally spaced in the membrane and the two BH3 domains are in close vicinity in the dimer interface, separated by >5 nm from the next BH3 pairs.
Vapor deposition of amino-functionalized self-assembled monolayers on MEMS (2003)

In the fabrication of MEMS devices, what has come to be known as "release stiction" occurs when the device is removed from the liquid phase into the ambient air. One widely used method for dealing with stiction is to deposit a hydrophobic coating on the surface of the device before it is removed from the liquid phase. This method can produce coatings with inconsistent morphology and device yield. This is to be compared with a new coating deposition scheme developed at Sandia National Labs, termed VSAMS (vapor-deposited self-assembled monolayers) that employs supercritical CO<sub>2</sub> drying and chemical vapor deposition to address many of the concerns associated with release stiction. VSAMS is attractive due to its process benefits, which include increased throughput, reduced waste, and most importantly, it can be easily scaled to full wafer production. It is also attractive because films produced by this method are uniform and very hydrophobic. The deposition step makes use of a class of compound that is particularly suited for vapor phase reactions, amino-functionalized silanes. The yield of microengine test devices coated with films made from amino-functionalized silanes was examined over an extended period. Their function was determined before and after the application of VSAMS. The advantage of using amino-functionalized silane precursors for VSAMS is related to the strength of the bond between the film and the polysilicon surface as evidenced by the fact that films made with these precursors are stable across the entire humidity scale.