gebhart/patrepeval huggingface dataset:
Blood Coagulation and Fibrinolysis in a Random Sample of 788 Men 54 Years Old (1972)

Summary Blood coagulation and fibrinolysis have been studied in a randomly selected population of 788 men 54 years of age. The mean values, standard deviations and distributions of recalcified plasma clotting time, PTT in silicone tubes and glass tubes, factor II-VII-X activity, factor VIII, fibrinogen, fibrinolytic activity in an euglobulin precipitation and plasminogen are presented. Linear regression analyses between the variables have been carried out. It was found that there is a significant correlation between fibrinogen and PTT in silicone tubes. An increased fibrinogen concentration thus tends to give prolonged clotting times. Factor VIII is negatively correlated to recalcified plasma clotting time and PTT in glass and silicone tubes. Increased factor VIII levels thus tend to shorten the clotting times. There is also a slight negative correlation between factor II-VII-X activity and PTT in glass tubes. In evaluating the significance of prolonged or shortened clotting times the inverse influence of fibrinogen and factor VIII on clotting time has to be considered. This is especially important in situations with increased frequency of thrombosis where both fibrinogen and factor VIII often are increased.
Purine Permease-Type Benzylisoquinoline Alkaloid Transporters in Opium Poppy (2019)

Although opiate biosynthesis has been largely elucidated, and cell-to-cell transport has been long postulated, benzylisoquinoline alkaloid (BIA) transporters from opium poppy (<i>Papaver somniferum</i>) have not been reported. Investigation of a purine permease-type sequence within a recently discovered opiate biosynthetic gene cluster led to the discovery of a family of nine homologs designated as BIA uptake permeases (BUPs). Initial expression studies in engineered yeast hosting segments of the opiate pathway showed that six of the nine BUP homologs facilitated dramatic increases in alkaloid yields. Closer examination revealed the ability to uptake a variety of BIAs and certain pathway precursors (e.g. dopamine), with each BUP displaying a unique substrate acceptance profile. Improvements in uptake for yeast expressing specific BUPs versus those devoid of the heterologous transporters were high for early intermediates (300- and 25-fold for dopamine and norcoclaurine, respectively), central pathway metabolites [10-fold for (<i>S</i>)-reticuline], and end products (30-fold for codeine). A coculture of three yeast strains, each harboring a different consecutive segment of the opiate pathway and <i>BUP1</i>, was able to convert exogenous Levodopa to 3 ± 4 mg/L codeine via a 14-step bioconversion process involving over a dozen enzymes. <i>BUP1</i> is highly expressed in opium poppy latex and is localized to the plasma membrane. The discovery of the BUP transporter family expands the role of purine permease-type transporters in specialized metabolism, and provides key insight into the cellular mechanisms involved in opiate alkaloid biosynthesis in opium poppy.
Test-suite reduction and prioritization for modified condition/decision coverage (2003)

Software testing is particularly expensive for developers of high-assurance software, such as software that is produced for commercial airborne systems. One reason for this expense is the Federal Aviation Administration's requirement that test suites be modified condition/decision coverage (MC/DC) adequate. Despite its cost, there is evidence that MC/DC is an effective verification technique and can help to uncover safety faults. As the software is modified and new test cases are added to the test suite, the test suite grows and the cost of regression testing increases. To address the test-suite size problem, researchers have investigated the use of test-suite reduction algorithms, which identify a reduced test suite that provides the same coverage of the software according to some criterion as the original test suite, and test-suite prioritization algorithms, which identify an ordering of the test cases in the test suite according to some criteria or goals. Existing test-suite reduction and prioritization techniques, however, may not be effective in reducing or prioritizing MC/DC-adequate test suites because they do not consider the complexity of the criterion. This paper presents new algorithms for test-suite reduction and prioritization that can be tailored effectively for use with MC/DC. The paper also presents the results of empirical studies of these algorithms.
Toxicity of Alkyl 2-Cyanoacrylates (1966)

THE USE of a tissue adhesive for surgical procedures has long been an appealing possibility. The development of such an adhesive in the form of methyl 2-cyanoacrylate monomer has prompted a large number of clinical and experimental studies. Many of these have pointed the way toward adoption of this material in the operating room, but all too frequently there has been an expression of dissatisfaction and the desire for a less toxic material. The synthesis of other members of the alkyl 2-cyanoacrylate family offered the opportunity to investigate homologues of potentially greater tissue compatibility. As yet there have been only a few comparative studies of these materials. Healey et al,<sup>1</sup>performing vascular anastomoses, found the isobutyl monomer to be approximately as effective as the methyl compound. Woodward et al<sup>2</sup>compared the methyl, hexyl, and decyl monomers and concluded that increasing alkyl chain length is associated with decreasing histotoxicity.
[Molecular characterization and phylogenetic analysis of porcine epidemic diarrhea virus field strains in central China during 2010-2012 outbreaks]. (2013)

Since late 2010, porcine epidemic diarrhea virus (PEDV) has been re-emerging in central China. To explore the possible reason of the PEDV outbreaks, twelve PEDV field strains were isolated from different swine breeding farms in central China during 2010-2012, and molecular diversity, phylogenetic relationships of these strains with other PEDV reference strains were investigated. Sequence analysis of S, M and ORE3 genes revealed that the central China PEDV isolates had several specific nucleotides and amino acids which were different from PEDV reference strains. In addition, the entire S genes of eleven central China PEDV isolates were found to be nine nucleotides longer in length than CV777 and large number of amino acid variations was accumulated in the N-terminal region of S gene. Phylogenetic analysis showed that the central China PEDV isolates had close relationship with Korea strains (2007-2009), Thailand strains (2007-2008), Vietnam strains (2009-2010), Japan strains (2010), and other prevailing strains from other parts of China (2010-2012). However, they differed genetically from European strains (CV777, Brl/87), China strains (2003-2007) and the vaccine strains (CV777) used in China. These results imply that a rapid variation and evolution of central China PEDV strains has occurred in recent years, and a more efficient vaccine strain should be selected to prevent and control outbreaks of PEDV in China.
Efficient tapering to the fundamental quasi-TM mode in asymmetrical waveguides (2010)

The tapering problem of the fundamental quasi-TM mode in thin asymmetrical waveguides is investigated.Mode conversions are found to be at the origin of the failing adiabatic tapers.We propose and investigate three non-adiabatic taper solutions, a focusing grating coupler, a lensed taper and a discontinuous taper, which circumvent these mode conversions.
Using VRML in a client-server architecture to visualise a simplified simulation model of tumor growth in vitro (2002)

The aim of this paper is to demonstrate the impact that modern visualization Web-based techniques can have on the simulation of biological processes such as tumour growth. Therefore, a simplified three-dimensional cytokinetic simulation model of tumour growth in vitro has been developed. Results concerning the development of a small cell lung cancer (SCLC) tumour spheroid in cell culture have been obtained and their behaviour has been compared with both published data and laboratory experience. A client-server architecture allowing real time surface and volume rendering using a standard Web browser has been proposed. Its application to the model has led to a spectacular three-dimensional visualization of both the external and the internal structure of a growing tumour spheroid.
Hot spots on rails [Internet hotspots in high-speed trains] (2005)

Mobile data connectivity is spreading to the railway industry. While passengers and crews of ships and aircraft have increasingly been able to access the Internet and check their emails, train travelers have been forced to use their laptops `offline'. The widespread use of tunnels and carriages built as thick metal structures is a constant barrier to seamless cellular communications that radio waves find it difficult to penetrate from the outside. In this paper, the author looks at how rail operators are turning high-speed trains into Internet hotspot. Onboard WLANs is the approach unanimously chosen by a range of technology companies addressing the incipient market. While some vendors have based their systems on satellite connectivity, other are using a combination of satellite and cellular. WiMAX technology is currently being tested as a possible backhaul platform.
Semi-supervised Relation Extraction with Large-scale Word Clustering (2011)

We present a simple semi-supervised relation extraction system with large-scale word clustering. We focus on systematically exploring the effectiveness of different cluster-based features. We also propose several statistical methods for selecting clusters at an appropriate level of granularity. When training on different sizes of data, our semi-supervised approach consistently outperformed a state-of-the-art supervised baseline system. 1
Classical Planning in Deep Latent Space: Bridging the Subsymbolic-Symbolic Boundary (2017)

Current domain-independent, classical planners require symbolic models of the problem domain and instance as input, resulting in a knowledge acquisition bottleneck. Meanwhile, although deep learning has achieved significant success in many fields, the knowledge is encoded in a subsymbolic representation which is incompatible with symbolic systems such as planners. We propose LatPlan, an unsupervised architecture combining deep learning and classical planning. Given only an unlabeled set of image pairs showing a subset of transitions allowed in the environment (training inputs), and a pair of images representing the initial and the goal states (planning inputs), LatPlan finds a plan to the goal state in a symbolic latent space and returns a visualized plan execution. The contribution of this paper is twofold: (1) State Autoencoder, which finds a propositional state representation of the environment using a Variational Autoencoder. It generates a discrete latent vector from the images, based on which a PDDL model can be constructed and then solved by an off-the-shelf planner. (2) Action Autoencoder / Discriminator, a neural architecture which jointly finds the action symbols and the implicit action models (preconditions/effects), and provides a successor function for the implicit graph search. We evaluate LatPlan using image-based versions of 3 planning domains: 8-puzzle, Towers of Hanoi and LightsOut.
IONIZATION EFFICIENCY MEASUREMENTS WITH THE MICROWAVE DISCHARGE ION SOURCE MIDAS (2000)

A microwave discharge ion source (MIDAS) has been designed in order to obtain high efficiencies for positive ionization of the recoils which will be produced with the EXCYT facility at LNS and some experience has been gained from tests with the prototype. In the mid of 1998 the source has been redesigned: the microwave power at a frequency of 2.45 GHz (2 kW continuous wave) is supplied to the plasma by a microwave line that incorporates a four step binomial matching transformer. The extraction system has also been modified to a three electrode system. The advantage of such a source with respect to other sources for radioactive beams consists of a ionization process which is not element dependent, thus obtaining quite high efficiencies for light and heavy ions (2 % to 50 % depending on the base pressure conditions) and of a short delay time (some tens of ms are estimated). Hereinafter the result of the efficiency tests are reported. 1 THE SOURCE DESIGN The MIDAS ion source is a compact microwave discharge source which exploits the principle of the off-resonance discharge to generate an overdense-low-temperature plasma which is an effective tool to generate 1+ ion beams with high efficiency, short delay time and low energy spread. The prototype of the MIDAS source was tested in 1997-98 [1] but the results were not acceptable with respect to the efficiency request, mainly because of the low RF power coupled to the plasma. Some modifications have been introduced with respect to the prototype: • the injection of the microwaves is performed by means of a waveguide with an adequate matching system instead of an antenna; • the static longitudinal magnetic field is generated by two movable coils instead of one; • the extraction system is designed to sustain voltages up to 60 kV as demanded by the mass separator design and it is built with three electrodes in place of two; Figure 1 and 2 show respectively the layout of the microwave line and the drawing of the MIDAS source.
Combinatorial Materials Research Applied to the Development of New Surface Coatings XIII: An Investigation of Polysiloxane Antimicrobial Coatings Containing Tethered Quaternary Ammonium Salt Groups (2009)

High-throughput biological assays were used to develop structure - antimicrobial relationships for polysiloxane coatings containing chemically bound (tethered) quaternary ammonium salt (QAS) moieties. The QAS-functional polysiloxanes were derived from solution blends of a silanol-terminated polydimethylsiloxane, a trimethoxysilane-functional QAS (QAS-TMS), and methylacetoxysilane. Since the QAS moieties provide antimicrobial activity through interaction with the microorganism cell wall, most of the compositional variables that were investigated were associated with the chemical structure of the QAS-TMS. Twenty different QAS-TMS were synthesized for the study and the antimicrobial activity of sixty unique polysiloxane coatings derived from these QAS-TMS determined toward Escherichia coli , Staphylococcus aureus , and Candida albicans . The results of the study showed that essentially all of the compositional variables significantly influenced antimicrobial activity. Surface characterization of these moisture-cured coatings using atomic force microscopy as well as water contact angle and water contact angle hysteresis measurements indicated that the compositional variables significantly affected coating surface morphology and surface chemistry. Overall, compositional variables that produced heterogeneous surface morphologies provided the highest antimicrobial activity suggesting that the antimicrobial activity was primarily derived from the relationship between coating chemical composition and self-assembly of QAS moieties at the coating/air interface. Using data modeling software, a narrow region of the compositional space was identified that provided broad-spectrum antimicrobial activity.
Internet-based Electronic Markets (1999)

This paper provides an overview of Internet-based electronic markets as a mechanism to support the procurement of non-production related items (indirect procurement). We describe the general concept and provide a number of representative examples. We also put the approaches in perspective with earlier research on electronic markets and intermediaries, point out similarities with other concepts, and address some of the success factors that are critical to gain widespread adoption.
Volatile-Mediated Effects Predominate in Paraburkholderia phytofirmans Growth Promotion and Salt Stress Tolerance of Arabidopsis thaliana (2016)

Abiotic stress has a growing impact on plant growth and agricultural activity worldwide. Specific plant growth promoting rhizobacteria have been reported to stimulate growth and tolerance to abiotic stress in plants, and molecular mechanisms like phytohormone synthesis and 1-aminocyclopropane-1-carboxylate deamination are usual candidates proposed to mediate these bacterial effects. <i>Paraburkholderia phytofirmans</i> PsJN is able to promote growth of several plant hosts, and improve their tolerance to chilling, drought and salinity. This work investigated bacterial determinants involved in PsJN stimulation of growth and salinity tolerance in <i>Arabidopsis thaliana</i>, showing bacteria enable plants to survive long-term salinity treatment, accumulating less sodium within leaf tissues relative to non-inoculated controls. Inactivation of specific bacterial genes encoding ACC deaminase, auxin catabolism, <i>N</i>-acyl-homoserine-lactone production, and flagellin synthesis showed these functions have little influence on bacterial induction of salinity tolerance. Volatile organic compound emission from strain PsJN was shown to reproduce the effects of direct bacterial inoculation of roots, increasing plant growth rate and tolerance to salinity evaluated both <i>in vitro</i> and in soil. Furthermore, early exposure to VOCs from <i>P. phytofirmans</i> was sufficient to stimulate long-term effects observed in <i>Arabidopsis</i> growth in the presence and absence of salinity. Organic compounds were analyzed in the headspace of PsJN cultures, showing production of 2-undecanone, 7-hexanol, 3-methylbutanol and dimethyl disulfide. Exposure of <i>A. thaliana</i> to different quantities of these molecules showed that they are able to influence growth in a wide range of added amounts. Exposure to a blend of the first three compounds was found to mimic the effects of PsJN on both general growth promotion and salinity tolerance. To our knowledge, this is the first report on volatile compound-mediated induction of plant abiotic stress tolerance by a <i>Paraburkholderia</i> species.
EXPERIMENTAL INVESTIGATION ON VARYING THE COMPRESSION RATIO OF SI ENGINE WORKING UNDER DIFFERENT ETHANOL-GASOLINE FUEL BLENDS (1997)

Using different ethanol–gasoline fuel blends, a VARICOMP engine was used to study the effect of varying the compression ratio on SI engine performance. The performance tests were carried out using different percentages of ethanol in gasoline fuel, up to 40%, under variable compression ratio conditions. The results show that the engine indicated power improves with the percentage addition of the ethanol in the fuel blend. The maximum improvement occurs at 10% ethanol–90% gasoline fuel blend. © 1997 by John Wiley & Sons, Ltd.
A bandpass sigma-delta modulator IC with digital branch-mismatch correction (2003)

A bandpass sigma delta modulator, integrated in a 0.35 /spl mu/m CMOS technology, samples a 82 MHz signal with a 109 MHz clock. The resolution is 11 bits over a 200 kHz bandwidth. To reach higher sampling rates the integrated circuit sub-samples the signal and uses the conventional two-branch parallel structure. A novel digital correction technique reduces the mismatch between the parallel branches increasing the signal to image ratio by 10 to 15 dB. This technique can be extended to structures with higher levels of parallelism.
Aqueous Stable Ti<sub>3</sub>C<sub>2</sub> MXene Membrane with Fast and Photoswitchable Nanofluidic Transport (2018)

High, stable, and modulatable ionic conductivity is important for many nanofluidic applications of layered two-dimensional (2D) membranes. In this study, we demonstrate a proton and ionic conductivity of the Ti<sub>3</sub>C<sub>2</sub>T <sub>x</sub> membrane that is orders of magnitude higher than that of bulk solution at low concentrations. Importantly, the membrane is highly stable in aqueous solution without any modification, due to the strong and attractive interlayer van der Waals interaction and weak electrostatic repulsive interaction. Furthermore, by exploiting the intrinsic photothermal property of MXene, we demonstrate that the ionic conductivity can be reversely, rapidly, and completely switched on or off with laser light. This study should prove MXene membrane as a suitable platform to study and utilize nanofluidic ion transport. It should also inspire future studies to manipulate the mass transport through 2D membranes using their inherent physicochemical properties.
Isolation and characterization of an extracellular heat stable lipase produced by Pseudomonas fluorescens MC50 (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation and characterization of an extracellular heat stable lipase produced by Pseudomonas fluorescens MC50Faruk Bozoglu, Harold E. Swaisgood, and Daniel M. Adams Jr.Cite this: J. Agric. Food Chem. 1984, 32, 1, 2–6Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://pubs.acs.org/doi/10.1021/jf00121a001https://doi.org/10.1021/jf00121a001research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Non-emissive plastic colour filters for fluorescence detection (2012)

We report the fabrication of non-emissive short- and long-pass filters on plastic for high sensitivity fluorescence detection. The filters were prepared by overnight immersion of titania-coated polyethylene terephthalate (PET) in an appropriate dye solution - xylene cyanol for short-pass filtering and fluorescein disodium salt for long-pass filtering - followed by repeated washing to remove excess dye. The interface between the titania and the dye molecule induces efficient quenching of photo-generated excitons in the dye molecule, reducing auto-fluorescence to negligible values and so overcoming the principal weakness of conventional colour filters. Using the filters in conjunction with a 505 nm cyan light-emitting diode and a Si photodiode, dose-response measurements were made for T8661 Transfluosphere beads in the concentration range 1 × 10(9) to 1 × 10(5) beads μL(-1), yielding a limit of detection of 3 × 10(4) beads μL(-1). The LED/short-pass filter/T8661/long-pass filter/Si-photodiode combination reported here offers an attractive solution for sensitive, low cost fluorescence detection that is readily applicable to a wide range of bead-based immunodiagnostic assays.