gebhart/patrepeval huggingface dataset:
Technology Use in ESL: An Investigation of Students' Experiences and the Implications for Language Education. (2010)

In Australia, information and communication technologies (ICT) are a significant element of a multicultural and multilingual society. However, some people (in particular, international students, immigrants, refugees) may experience many challenges because they use technology in English as their second language (ESL) and in a new sociocultural environment. Informed by a sociocultural perspective and Bill Green's 3-D model (Green, 1988), the study views technology as a complex social, multimodal, and multidimensional practice which requires relevant capabilities - technoliteracy. The case studies focus on four international students and their experiences with technology use in ESL. This paper introduces five interrelated categories of challenges - navigation, comprehension, application of discourses, critical analysis and the affective domain. It also outlines the capabilities required for technoliteracy practices in ESL - the English language capabilities, ICT capabilities, contextual capabilities and critical capabilities. The discussion focuses on the need for educators to rethink the use of ICT in a language classroom.
MEMS tunable Michelson interferometer with robust beam splitting architecture (2009)

A new beam splitter is proposed to realize a completely integrated Michelson interferometer, where a single medium interface (Si/Air) is used for optical beam splitting. This offers a stable splitting ratio over a very wide spectral range. Using this technique on SOI wafers, with a moving mirror, a highly robust and tunable interferometer is fabricated. The tunable interferometer is tested experimentally by measuring optical interference versus mirror displacement.
Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction (2006)

Signaling in the nervous system requires matching of neurotransmitter receptors with cognate neurotransmitters at synapses. The vertebrate neuromuscular junction is the best studied cholinergic synapse, but the mechanisms by which acetylcholine is matched with acetylcholine receptors are not fully understood. Because alterations in neuronal calcium spike activity alter transmitter specification in embryonic spinal neurons, we hypothesized that receptor expression in postsynaptic cells follows changes in transmitter expression to achieve this specific match. We find that embryonic vertebrate striated muscle cells normally express receptors for glutamate, GABA, and glycine as well as for acetylcholine. As maturation progresses, acetylcholine receptor expression prevails. Receptor selection is altered when early neuronal calcium-dependent activity is perturbed, and remaining receptor populations parallel changes in transmitter phenotype. In these cases, glutamatergic, GABAergic, and glycinergic synaptic currents are recorded from muscle cells, demonstrating that activity regulates matching of transmitters and their receptors in the assembly of functional synapses.
Justicidin A inhibits AKT/mTOR and activates type III PI3K/beclin 1 signaling pathways leading to autophagy of human colorectal cancer cells (2010)

Justicidin A (JA), a pure compound isolated from Justicia procumbens , is a traditional herbal remedy for treatment of fever, pain, and cancer in Taiwan. Treatment of JA not only increased the expression of autophagic marker microtubule‐associated protein 1 light chain‐II by immunoblotting and confocal microscopy, but also augmented the formation of acidic vesicular organelles by flow cytometry in HT‐29 cells. Further study indicated that the expression of p‐AKT, p‐mTOR, p‐p70S6k was decreased whereas that of type III PI3K, becline 1, and Atg5‐Arg12 was increased in JA‐treated cells. Annexin V‐FITC and propidium iodine staining followed by flow cytometry revealed that induction of early apoptosis was displayed at 12 h that was later than the induction of autophagy. Of note, pre‐treatment of the cells with autophagy inhibitor 3‐methyladenine reduced JA‐induced early apoptotic rate. Oral administration of JA (6.2 mg/kg) once a day for 56 consecutive days was shown to suppress the growth and induce apoptosis and autophagy of HT‐29 cells transplanted to NOD‐SCID mice, suggesting chemotherapeutic potential of JA on human colorectal cancer cells. (Supported in part by National Science Council, Taipei, Taiwan, No. NSC 96‐2313‐B‐309‐001‐MY2 and NSC 98‐2313‐B‐003‐002‐MY3).
Improvements in the accuracy and the repeatability of long trace profiler measurements (1999)

Modifications of the long trace profiler at the Advanced Photon Source at Argonne National Laboratory have significantly improved its accuracy and repeatability for measuring the figure of large flat and long-radius mirrors. Use of a Dove prism in the reference beam path corrects phasing problems between mechanical errors and thermally induced system errors. A single reference correction now completely removes both of these error signals from the measured surface profile. The addition of a precision air conditioner keeps the temperature in the metrology enclosure constant to within +/-0.1 degrees C over a 24-h period and has significantly improved the stability and the repeatability of the measurements. Long-radius surface curvatures can now be measured absolutely with a high degree of confidence. These improved capabilities are illustrated with a series of measurements of a 500-mm-long mirror with a 5-km radius of curvature. The standard deviation in the average of ten slope profile scans is 0.3 microrad, and the corresponding standard deviation in the height error is 4.6 nm.
Small Molecule-Induced Allosteric Activation of the <i>Vibrio cholerae</i> RTX Cysteine Protease Domain (2008)

Vibrio cholerae RTX (repeats in toxin) is an actin-disrupting toxin that is autoprocessed by an internal cysteine protease domain (CPD). The RTX CPD is efficiently activated by the eukaryote-specific small molecule inositol hexakisphosphate (InsP6), and we present the 2.1 angstrom structure of the RTX CPD in complex with InsP6. InsP6 binds to a conserved basic cleft that is distant from the protease active site. Biochemical and kinetic analyses of CPD mutants indicate that InsP6 binding induces an allosteric switch that leads to the autoprocessing and intracellular release of toxin-effector domains.
Coccidia: A review of recent advances on immunity and vaccine development (1993)

The genus Eimeria contains a number of obligate intracellular protozoan parasites with a complicated life-cycle involving both asexual and sexual stages of development. Coccidiosis is caused by Eimeria infecting primarily the intestine of the susceptible host, thereby seriously impairing the growth and feed utilization of poultry and other livestock. The desire to develop a vaccine against Eimeria has promoted active research to elucidate the mechanisms of protective immunity and identification of candidate vaccine antigens. Protozoa are unique in their modes of transmission and nature of disease manifestations, the significance of which should be considered in the development of a control strategy. An intricate and complex interplay of different cell populations and cytokines is involved not only in the pathogenesis of coccidiosis, but also in the development of protective immunity. Thus, comprehensive understanding of the events leading to protection following Eimeria infection will be crucial for the development of an effective vaccine.
A Method for Resolving Multiple Responses in a Parallel Search File (1961)

It is possible to build memories in which the contents of all registers are tested simultaneously, and in which there is a single indication of the presence or absence of any number of positive responses to the test criterion. A method is described for separately identifying the members of a set of responses by presenting sequences of tests which generate an identification number for each member. The testing algorithm is easily mechanized, and the number of tests required per item is approximately proportional to the logarithm of the number of file registers. The method also may be used to search for items with contents falling within arbitrary numerical ranges.
MicroRNA-125b Functions as a Tumor Suppressor in Hepatocellular Carcinoma Cells (2012)

MicroRNAs (miRNAs) are important regulators of multiple cellular processes, and the deregulation of miRNA is a common event in diverse human diseases, particularly cancer. However, the mechanisms underlying the relationship between disordered miRNA expression and tumorigenesis have remained largely unknown. In this study, we demonstrated the down-regulation of miR-125b in hepatocellular carcinoma (HCC) tissues and HCC cell lines by Northern blot and quantitative RT-PCR analyses. The ectopic expression of miR-125b reduced the cellular proliferation and cell cycle progression of HCC cells by targeting Mcl-1 and IL6R. Furthermore, the miR-125b-induced inhibition of cell proliferation was rescued by the expression of Mcl-1 or IL6R variants that lacked 3' UTRs. Thus, this study revealed the differential expression of miR-125b in HCC cells and elucidated its potential as a tumor suppressor in HCC development.
Gray Component Replacement by the Neugebauer Equations (1990)

The Neugebauer equations give us a set of dot areas to reproduce a given target color( X, Y, Z ) as solutions of non-linear simultaneous equations, not only in case of three color reproduction but also four color one. We have only three equations, therefore one dot area has to be fixed prior to solve the Neugebauer equations. The way to apply black printers could be classified into varieties, according to how to fix one dot area among four ink dot areas. Conventional black printer given by black rate with minimum dot area in three color reproduction, maximum black in which one of three colors is zero and skeleton black to avoid black dots for high-light are discussed in this paper. Studies give us clear view on the black printer applications in different manners and results are summarized as restatements of concepts and redefinitions of technical terms. Almost technical terms used in past related with black printers explain well local photographic processes which were used before digital handling as continuous tone color separation. Now in modern processing of color information, it is not necessary to hold simulation of photographic image treatments. Relation between target tristimulus values and four dot areas is directly given by the Neugebauer equations.
Er:YAG laser skin resurfacing using repetitive long‐pulse exposure and cryogen spray cooling: I. Histological study* (2001)

Dermal collagen coagulation and neo-collagen formation to depths similar to those observed after CO(2) laser resurfacing can be achieved without complete ablation of the epidermis by rapidly stacking long Er:YAG laser pulses. Application of CSC does not offer significant epidermal protection for a given dermal coagulation depth.
Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/<i>SESN3</i>/p21<sup>Cip1/WAF1</sup>pathways (2013)

Oncogenes of the RAS family regulate many of the cell's activities, including proliferation, survival and differentiation. Activating mutations in these genes are common events for many types of cancer. One of the contradictory points concerning the biological significance of Ras activation is its dual effect (pro- or anti-proliferative) on cell reproduction. One of mechanisms by which Ras proteins influence cell growth is a regulation of intracellular level of reactive oxygen species (ROS), second messengers affecting variety of cellular processes including cell proliferation. Recently it was shown that repression of SESN1 and SESN3 genes, whose protein products control regeneration of peroxiredoxins, can play a critical role in Ras-induced ROS upregulation. In the present study we have found that Ras-induced repression of SESN3 expression and ROS upregulation is mediated via the modifications of transcriptional activity of HSF1. Interestingly, mutant Ras overexpression altered the activity of HSF1 in opposite directions in different cell contexts, in particular in human normal fibroblasts and HaCaT immortalized keratinocytes, but these opposite changes caused similar repression of SESN3 expression followed by elevation of ROS content and inhibition of cell proliferation in corresponding cell types. The inhibitory effect on cell proliferation was mediated by upregulation of p21(Cip1/WAF1). Thus, HSF1/SESN3/ROS/p21(Cip1/WAF1)-mediated deceleration of cell growth may contribute to cell defense systems protecting the organism from excessive proliferation of cells that overexpress activated Ras oncoproteins.
Some Characteristics of the Pelagic Redfish (Sebastes Mentella Travin) from Weather Station Alfax (1969)

The existence of a permanent pelagic population of the redfish Sebastes mentella Travin in the Irminger Sea has been confirmed as a result of successful angling trials carried out by ships occupying Weather Station Alfa (62°N, 33°W) during the years 1962 to 1965. No specimens of S. marinus or ‘intermediate’ forms were found amongst the 207 specimens returned to the laboratory. The sample was predominantly female (7:1) although males were found in equal or greater numbers in the period late December to March. All females were sexually mature and all males were approaching or had reached full sexual maturity. Captures were made at depths ranging from 50 to 350 m but chiefly between 100 and 150 m in the summer. Fishing was most successful during the periods May to August and December to March. There was considerable but continuous variation in body proportions and age/length relationships. Much less variation occurred in the numbers of vertebrae and of pyloric caeca. Allowing one pair of growth rings to one year's growth, it is thought that the ages ranged from approximately 15 to 57 years, with a mean age of 31 years and it is believed that sexual maturity in females occurs between 15 and 25 years of age. Fecundity, which varies according to size (length), ranges from approximately 20,000 to 150,000. No evidence was obtained to show the relationship of this population to any other redfish population nor is there any clear evidence to demonstrate migration or movement. The seasonal variation in the number of males caught at Station Alfa may possibly be due to either horizontal or vertical migration.
CHILD ROAD SAFETY (2001)

The UK Government's attitude to child road safety is outlined. Data for child road casualties in 2000 showed that there had been a 24% reduction in child deaths and serious injuries when compared with the average for 1994-1998, the baseline for the 2010 target of a 50% reduction. Child deaths in 2000 were 14% down on 1999 figures but child pedestrian deaths were unchanged. The drop in child deaths and serious injuries was attributed to less drink-driving, more seatbelt wearing, more pedestrianised streets, more controlled crossings and more local safety schemes. Improvements to the child safety record are being made by enforcement, education, engineering and evaluation. For the covering abstract see ITRD E114935.
Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study (2003)

A simple six point score based on confusion, urea, respiratory rate, blood pressure, and age can be used to stratify patients with CAP into different management groups.
Optimization and Control of Cyber-Physical Vehicle Systems (2015)

A cyber-physical system (CPS) is composed of tightly-integrated computation, communication and physical elements. Medical devices, buildings, mobile devices, robots, transportation and energy systems can benefit from CPS co-design and optimization techniques. Cyber-physical vehicle systems (CPVSs) are rapidly advancing due to progress in real-time computing, control and artificial intelligence. Multidisciplinary or multi-objective design optimization maximizes CPS efficiency, capability and safety, while online regulation enables the vehicle to be responsive to disturbances, modeling errors and uncertainties. CPVS optimization occurs at design-time and at run-time. This paper surveys the run-time cooperative optimization or co-optimization of cyber and physical systems, which have historically been considered separately. A run-time CPVS is also cooperatively regulated or co-regulated when cyber and physical resources are utilized in a manner that is responsive to both cyber and physical system requirements. This paper surveys research that considers both cyber and physical resources in co-optimization and co-regulation schemes with applications to mobile robotic and vehicle systems. Time-varying sampling patterns, sensor scheduling, anytime control, feedback scheduling, task and motion planning and resource sharing are examined.
Using languages for capture, analysis and display of performance information for parallel and distributed applications (2002)

A graphical performance display tool can offer insights into the nature of a program's performance that would be difficult, and sometimes impossible, to achieve with a traditional textual view of performance activity. Two languages with which programmers can specify the collection and display of performance information about parallel and distributed application programs are discussed. It is demonstrated that visual environments for program information display may be developed within a uniform conceptual framework. The display language allows the user to create displays tailored for viewing the performance of various monitored application components. The next step is to use this monitored information as input to a variety of user-specified performance models.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
REVIEWS (1969)

Journal Article REVIEWS Get access Theocracy and Eschatology. By OTTO PLOCER; translated by S. RUDMAN. Richmond: John Knox Press, 1968 viii+124 pages. $4.95. R. B. Y. SCOTT R. B. Y. SCOTT Princeton University Search for other works by this author on: Oxford Academic Google Scholar Journal of the American Academy of Religion, Volume XXXVII, Issue 4, December 1969, Pages 378-a–378, https://doi.org/10.1093/jaarel/XXXVII.4.378-a Published: 01 December 1969
Defective Endothelium-dependent Relaxation of Vascular Smooth Muscle and Endothelial Cell Ca2+ Signaling in Mice Lacking Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 3 (1997)

Sarco(endo)plasmic reticulum Ca2+ ATPase isoform 3 (SERCA3) is one of two Ca2+ pumps serving intracellular Ca2+ signaling pools in non-muscle tissues; however, unlike the ubiquitous SERCA2b, it exhibits a restricted cell-type distribution. Gene targeting was used to generate a mouse with a null mutation in the SERCA3 gene. Homozygous mutant mice were viable, fertile, and did not exhibit an overt disease phenotype. Because SERCA3 is expressed in arterial endothelial cells, aortic ring preparations were analyzed to determine whether it is involved in the regulation of vascular tone. Contraction-isometric force relations in response to phenylephrine or KCl, as well as relaxation produced by exposure to a nitric oxide donor, were similar in wild-type and null mutant aortas. Acetylcholine-induced endothelium-dependent relaxation of aortas after precontraction with phenylephrine was significantly reduced in homozygous mutants (61.3 +/- 5.6% in wild type, 35.4 +/- 7.3% in mutants). Ca2+ imaging of cultured aortic endothelial cells demonstrated that the acetylcholine-induced intracellular Ca2+ signal is sharply diminished in SERCA3-deficient cells and also indicated that replenishment of the acetylcholine-responsive Ca2+ stores is severely impaired. These results indicate that SERCA3 plays a critical role in endothelial cell Ca2+ signaling events involved in nitric oxide-mediated relaxation of vascular smooth muscle.
Adaptive Filtering in Optical Coherent Flexible Bit-Rate Receivers in the Presence of State-of-Polarization Transients and Colored Noise (2019)

In this article, we analyze the performance of adaptive filtering in the context of dual-polarization coherent optical flexible bit-rate transceivers. We investigate the ability of different adaptive algorithms to track fast state-of-polarization (SOP) transients in the presence of colored noise. Colored noise exists due to the concatenation of Wavelength Selective Switches (WSSs) and polarization dependent loss (PDL) which can be considered as spatially dependent noise. We consider the use of different modulation formats, and the practical limitation of error signal feedback delay in decision-directed adaptive filters is also taken into account. The back-to-back required signal-to-noise ratio (RSNR) penalty that can be tolerated determines the maximum SOP rate of change that can be tracked by the adaptive filters as well as the filter’s adaptive step size. We show that the recursive least squares algorithm, using the covariance matrix as an aggressive “step size,” has a much better convergence speed compared to the least mean squares (LMS) and normalized LMS (NLMS) algorithms in the presence of colored noise in the fiber. However, the three algorithms have similar tracking capabilities in the absence of colored noise.
Complete nucleotide sequence of cDNA for the cytotoxin alpha sarcin (1990)

Journal Article Complete nucleotide sequence of cDNA for the cytotoxin alpha sarcin Get access Tatsuzo Oka, Tatsuzo Oka Search for other works by this author on: Oxford Academic PubMed Google Scholar Yasuo Natori, Yasuo Natori Search for other works by this author on: Oxford Academic PubMed Google Scholar Shoji Tanaka, Shoji Tanaka 1Department Institute for Biomedical ResearchWakayama, Shimamoto-cho, Mishima, Osaka 618 Search for other works by this author on: Oxford Academic PubMed Google Scholar Kunio Tsurugi, Kunio Tsurugi 2Department of Biochemistry, Yamanashi Medical CollegeTaniaho, Nakakoma, Yamanashi 409-38, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yaeta Endo Yaeta Endo 2Department of Biochemistry, Yamanashi Medical CollegeTaniaho, Nakakoma, Yamanashi 409-38, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 7, 11 April 1990, Page 1897, https://doi.org/10.1093/nar/18.7.1897 Published: 11 April 1990 Article history Accepted: 26 February 1990 Published: 11 April 1990
Theory of X-Ray Diffraction by a Vibrating Crystal (1969)

The scattering amplitude for x-ray diffraction by a vibrating crystal is obtained. The Bragg diffracted propagators for the perfect crystal are replaced by new propagators in which the Fourier transform of the polarizability of the crystal, v(H), is multiplied by the Bessel function of zero order, J0(H·Aq), of the product of the vibrational amplitude Aq and a reciprocal lattice vector H, in a similar fashion to the correction by the Debye-Waller factor in the thermal problem. The scattering amplitude contains both dynamical and kinematical contribution. The case of ideal thickness vibration is studied in detail in the Laue geometry. The real part of the perturbed scattering amplitude is proportional to v(H) sin (H·Aq). This theory elucidates the transition from dynamical to kinematical scattering, that is, a decrease in extinction, as a function of the vibration amplitude.