gebhart/patrepeval huggingface dataset:
A Computer Science Practicum (1975)

An approach is described for introducing practical work experience into an undergraduate computer science curriculum. This approach differs from others which have been reported in that it is not necessary for the student to make any arrangements for academic credit in advance. The requirements for obtaining practicum credit are described, and examples of projects which have received such credit are given. This approach has made a significant contribution to the educational program by offering academic credit for learning experiences which are difficult to duplicate in a typical computer science curriculum.
Peptide-mediated suppression of experimental autoimmune uveoretinitis in mice: development of a peptide vaccine (1996)

Experimental autoimmune uveoretinitis (EAU) is an animal model of antigen-specific, Th cell-mediated, organ-specific autoimmune disease. EAU is induced by immunization of B10.A mice with interphotoreceptor retinoid-binding protein (IRBP). Pre-treatment with synthetic peptide 518-529 derived from IRBP prevented IRBP-mediated EAU. This was accompanied by augmentation of the IRBP-specific IgG1 antibody (Th2) response and down-regulation of the IRBP-specific IgG2a (Th1) response. Consistent with this is the observation that two of two T cell lines established from p518-529-primed mice produced Th2-type cytokines (IL-4 and IL-10), whereas three of three T cell lines obtained from IRBP-primed mice produced Th1-type cytokines (IL-2 and IFN-gamma). Together this suggests the possibility that p518-529 priming causes a shift from a Th1-to a Th2-dominated immune response, thereby playing a pivotal role in the prevention of IRBP-mediated EAU. Furthermore, co-transfer of cells from a CD4+ p518-529-specific T cell line prevented the development of EAU after adoptive transfer of spleen cells from mice with EAU into normal mice. These findings contribute to our understanding of the mechanism of EAU, particularly with respect to the down-regulation of Th1-initiated inflammation, and may prove valuable for designing a peptide vaccine for EAU in the future.
Phased-array antenna beam steering with a photonic I-Q beam-forming network (1992)

A photonic in-phase/quadrature (I-Q) RF phase shifter utilizing the signals from two integrated optic Mach-Zehnder modulators has been tested. This system demonstrates the capability of 360-deg phase control, less than 1-deg RF errors at constant amplitude, and less than 0.5-degree errors over a 30 dB RF amplitude taper. Using this technique, a four-channel beam forming network was also developed and integrated with a printed patch, lightweight phased array antenna. High accuracy linear beam control was achieved. Null patterns of more than 30 dB were produced on boresight. The null was steered to greater than 30-deg from boresight with a linear accuracy of about 1 deg.
F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis (2012)

This systematic review was designed to provide more precise effect estimates of inhibitor development for the various types of F8 gene mutations in patients with severe hemophilia A. The primary outcome was inhibitor development and the secondary outcome was high-titer-inhibitor development. A systematic literature search was performed to include cohort studies published in peer-reviewed journals with data on inhibitor incidences in the various F8 gene mutation types and a mutation detection rate of at least 80%. Pooled odds ratios (ORs) of inhibitor development for different types of F8 gene mutations were calculated with intron 22 inversion as the reference. Data were included from 30 studies on 5383 patients, including 1029 inhibitor patients. The inhibitor risk in large deletions and nonsense mutations was higher than in intron 22 inversions (pooled OR = 3.6, 95% confidence interval [95% CI], 2.3-5.7 and OR = 1.4, 95% CI, 1.1-1.8, respectively), the risk in intron 1 inversions and splice-site mutations was equal (pooled OR = 0.9; 95% CI, 0.6-1.5 and OR = 1.0; 95% CI, 0.6-1.5), and the risk in small deletions/insertions and missense mutations was lower (pooled OR = 0.5; 95% CI, 0.4-0.6 and OR = 0.3; 95% CI, 0.2-0.4, respectively). The relative risks for developing high titer inhibitors were similar.
The significance of studios (2000)

Abstract The suggestion that it is time to reassert the significance of studios for art therapy caused some disquiet when I first introduced it in a paper at the art therapy conference (TAAT) in Birmingham in 1998. Since that time a number of people (in personal communications) have told me that they think the idea is not feasible because of the way space increasingly has to be shared in public institutions. There also seems to be a fear that asserting the need for studio space could detract from the psychotherapeutic nature of art therapy relationships. I have no wish to do that, but I am interested in exploring the real and the symbolic qualities of physical space and how they might enhance the capacity for mental absorption that is often lost in the midst of distress. The part played by the therapy relationship in facilitating mental space is also acknowledged although not the central focus of the discussion. The case for the value of a studio-based practice has been made retrospectively in a range of art therapy literature. Here I make a contemporary case for the significance of studios. The studio rooms of well-known artists are compared to those found in art therapy. Studios offer the implicit message of there being time for exploration, play and reverie. They can enable the art therapist to provide an additional dimension and a greater capaciousness for their relationships with clients. Given the high levels of alienation and the complexity of difficulties faced by clients of the public sector, having a studio in which to practise might make the difference between being able to offer therapy and it not being appropriate to do so. There is a cluster of factors that resulted in the disappearance of some studios, but fundamentally their loss in the 1980s and 1990s is linked to the economic climate. I imply that many developments in theory and practice can be understood dynamically when moving our attention backwards and forwards between the intimacy of the relationship and the political circumstances of the period. This is in stark contrast to much psychotherapeutic literature that has an exclusively clinical focus and only rarely acknowledges the link between changes in theory and practice and the wider context. In keeping with the ethos of Roth and Fonagys What Works for Whom? (1996), the paper suggests that different kinds of studios may be appropriate for different kinds of client need, but this is just one reason why it could be a good time to challenge the lament over studios and start a song about their current place in the provision of a good practice.
Darstellung und Schwingungsspektren von Fluoro-Chloro-Iridaten(IV) einschließlich der Stereoisomeren / Preparation and Vibrational Spectra of Fluoro-Chloro-Iridates(IV) Including Stereoisomers (1984)

The reaction of [IrCl 6 ] 2- with BrF 3 generates the mixed complexes [IrF n Cl 6-n ] 2 -, n = 1-5, of which the species with n = 2, 3, 4 are ds-configurated. Due to the stronger trans-effect of Cl as compared to F on treatment of [IrF 5 Cl] 2 - and cis-[IrF 4 Cl 2 ] 2- with SOCl 2 the trans-isomers are formed stereospecifically. The pure fluoro-chloro-iridates(IV) are separated by ion exchange chromatography on diethylaminoethyl-cellulose. The vibrational spectra of the mixed ligand complexes are completely assigned according to point groups D 4h , C 4v , C 3v , and C 2v . The IrCl stretching vibration of [IrF 5 Cl] 2- is split by the isotopes 35 C1 and 37 Cl, showing two well resolved sharp Raman lines at 361 and 355 cm -1 .
Observation of two-dimensional hole gas with mobility and carrier density exceeding those of two-dimensional electron gas at room temperature in the SiGe heterostructures (2007)

Very high two-dimensional hole gas (2DHG) drift mobility of 3100cm2∕Vs is obtained at extremely high density of 41×1011cm−2 in the modulation doped, 20nm thick, strained Ge quantum well (QW) of SiGe heterostructure at room temperature. Very high 2DHG density is achieved by increasing the boron modulation doping, reducing the spacer layer thickness located between it and Ge QW, and increasing the valence-band offset of Ge QW, which also results in the enhancement of mobility. The obtained 2DHG mobility and carrier density exceed those reported for two-dimensional electron gas in the strained Si QW of SiGe heterostructures.
Temperature Dependence of Junction Transistor Parameters (1957)

Based on existing design theories and the known temperature behavior of the semiconductor properties, the temperature variations of transistor characteristics are calculated for four representative types. The results, expressed in terms of four-pole parameters and equivalent circuits, may serve as a guide line in transistor design and temperature compensation of transistor circuits.
Logic programming : proceedings of the 1996 Joint International Conference and Symposium on Logic Programming (1996)

Includes tutorials, invited lectures, and refereed papers on all aspects of logic programming including: Constraints, Concurrency and Parallelism, Deductive Databases, Implementations, Meta and Higher-order Programming, Theory, and Semantic Analysis. September 2-6, 1996, Bonn, Germany Every four years, the two major international scientific conferences on logic programming merge in one joint event. JICSLP'96 is the thirteenth in the two series of annual conferences sponsored by The Association for Logic Programming. It includes tutorials, invited lectures, and refereed papers on all aspects of logic programming including: Constraints, Concurrency and Parallelism, Deductive Databases, Implementations, Meta and Higher-order Programming, Theory, and Semantic Analysis. The contributors are international, with strong contingents from the United States, United Kingdom, France, and Japan. Logic Programming series, Research Reports and Notes
Defragmentation Scheme Based on Exchanging Primary and Backup Paths in 1+1 Path Protected Elastic Optical Networks (2017)

In elastic optical networks (EONs), a major obstacle to using the spectrum resources efficiently is the spectrum fragmentation. In the literature, several defragmentation approaches have been presented. For 1+1 path protection, conventional defragmentation approaches consider designated primary and backup paths. This exposes the spectrum to fragmentations induced by the primary lightpaths, which are not to be disturbed in order to achieve hitless defragmentation. This paper proposes a defragmentation scheme using path exchanging in 1+1 path protected EONs. We exchange the path function of the 1+1 protection with the primary toggling to the backup state, while the backup becomes the primary. This allows both lightpaths to be reallocated during the defragmentation process, while they work as backup, offering hitless defragmentation. Considering path exchanging, we define a static spectrum reallocation optimization problem that minimizes the spectrum fragmentation while limiting the number of path exchanging and reallocation operations. We then formulate the problem as an integer linear programming (ILP) problem. We prove that a decision version of the defined static reallocation problem is NP-complete. We present a spectrum defragmentation process for dynamic traffic, and introduce a heuristic algorithm for the case that the ILP problem is not tractable. The simulation results show that the proposed scheme outperforms the conventional one and improves the total admissible traffic up to 10%.
Reduced incidence of AD with NSAID but not H<sub>2</sub>receptor antagonists (2002)

Long-term NSAID use may reduce the risk of AD, provided such use occurs well before the onset of dementia. More recent exposure seems to offer little protection. Recently initiated randomized trials of NSAID for primary prevention of AD are therefore unlikely to show effects with treatment until participants have been followed for several years.
Narrow linewidth tunable operation of Er <sup>3+</sup> -doped single-mode fibre laser (1989)

Wavelength tunable operation of an Er3+-doped fibre laser has been demonstrated using a tunable ring resonator configuration. This configuration gives a stable narrow linewidth output exhibiting discrete tuning bands within a 70 nm wavelength region centred on the important 1550 nm telecommunications window.
Apolipoprotein L1, a Novel Bcl-2 Homology Domain 3-only Lipid-binding Protein, Induces Autophagic Cell Death (2008)

The Bcl-2 family proteins are important regulators of type I programmed cell death apoptosis; however, their role in autophagic cell death (AuCD) or type II programmed cell death is still largely unknown. Here we report the cloning and characterization of a novel Bcl-2 homology domain 3 (BH3)-only protein, apolipoprotein L1 (apoL1), that, when overexpressed and accumulated intracellularly, induces AuCD in cells as characterized by the increasing formation of autophagic vacuoles and activating the translocation of LC3-II from the cytosol to the autophagic vacuoles. Wortmannin and 3-methyladenine, inhibitors of class III phosphatidylinostol 3-kinase and, subsequently, autophagy, blocked apoL1-induced AuCD. In addition, apoL1 failed to induce AuCD in autophagy-deficient ATG5(-/-) and ATG7(-/-) mouse embryonic fibroblast cells, suggesting that apoL1-induced cell death is indeed autophagy-dependent. Furthermore, a BH3 domain deletion construct of apoL1 failed to induce AuCD, demonstrating that apoL1 is a bona fide BH3-only pro-death protein. Moreover, we showed that apoL1 is inducible by p53 in p53-induced cell death and is a lipid-binding protein with high affinity for phosphatidic acid (PA) and cardiolipin (CL). Previously, it has been shown that PA directly interacted with mammalian target of rapamycin and positively regulated the ability of mammalian target of rapamycin to activate downstream effectors. In addition, CL has been shown to activate mitochondria-mediated apoptosis. Sequestering of PA and CL with apoL1 may alter the homeostasis between survival and death leading to AuCD. To our knowledge, this is the first BH3-only protein with lipid binding activity that, when overproduced intracellularly, induces AuCD.
Film and Flesh (2001)

Clarence Major is the author of several award-winning novels, including Such Was The Season, Painted Turtle: Woman With Guitar, Dirty Bird Blues and Reflex and Bone Structure, My Amputations, as well as stories collected in Fun & Games (1990), a new edition of poetry, Configurations: New and Selected Poems 1958-1998 (a finalist for the National Book Award in 1999), and Necessary Distance (2001). He has also edited a number of anthologies, including Calling The Wind: Twentieth Century African-American Short Stories (1993) and The Garden Thrives: Twentieth Century African-American Poetry (1996). He has received numerous awards, among them a National Council on the Arts Award (1970), a Fulbright (1981-1983) and two Pushcart prizes (1976/1990). He teaches at the University of California, Davis.
CREB Is a Regulatory Target for the Protein Kinase Akt/PKB (1998)

The nuclear factor CREB stimulates the expression of cellular genes following its protein kinase A-mediated phosphorylation at Ser-133. Ser-133 phosphorylation, in turn, activates target gene expression by promoting recruitment of the co-activator CBP. Recent studies showing that CREB and its paralog CREM are required for survival of certain cell types prompted us to examine whether CREB is a nuclear target for activation via the growth factor-dependent Ser/Thr kinase Akt/PKB. When overexpressed in serum-stimulated cells, Akt/PKB potently induced Ser-133 phosphorylation of CREB and promoted recruitment of CBP. Correspondingly, Akt/PKB stimulated target gene expression via CREB in a phospho(Ser-133)-dependent manner. Akt/PKB induced CREB activity only in response to serum stimulation, and this effect was suppressed by the phosphatidylinositol 3-kinase inhibitor LY 294002. Our results support the notion that Akt/PKB promotes cell survival, at least in part, by stimulating the expression of cellular genes via the CREB/CBP nuclear transduction pathway.
The involvement of heat shock proteins in murine liver regeneration. (2007)

Partial hepatectomy (PHx) in mammals is a very common experimental model to investigate the process of liver regeneration. The surgery itself could give birth to a series of stresses, such as the temporary raise of body temperature and the ischaemia-reperfusion injury. Heat shock proteins (HSPs) were a family of stress-inducible proteins involved in maintaining cell homeostasis and regulating the immune system. In our study, we intended to investigate the expression and role of HSPs in liver regeneration. Using RT-PCR and Western blotting, we determined the expression in regenerating liver of HSP27, HSP60, HSP70 and HSP90 in mRNA level and protein level, respectively, with mice treated with sham operation as controls. We also used quercertin as an inhibitor of HSPs to explore their effects on liver regeneration. We found that hepatic expression of HSPs increased at the early phase of liver regeneration and declined to the constitutively low level later. Moreover, quercetin pretreatment delayed the progress of liver regeneration in mice via inhibition of HSPs. The results indicated that HSPs played an important role in liver regeneration.
To edit or not: the NgAgo story (2016)

New genome-editing approaches always receive widespread attention. But in the case of a novel Argonaute-based technique published last spring, attention has been particularly intense.
Active material, optical mode and cavity impact on nanoscale electro‐optic modulation performance (2017)

Abstract Electro‐optic modulation is a key function in optical data communication and possible future optical compute engines. The performance of modulators intricately depends on the interaction between the actively modulated material and the propagating waveguide mode. While a variety of high‐performance modulators have been demonstrated, no comprehensive picture of what factors are most responsible for high performance has emerged so far. Here we report the first systematic and comprehensive analytical and computational investigation for high‐performance compact on‐chip electro‐optic modulators by considering emerging active materials, model considerations and cavity feedback at the nanoscale. We discover that the delicate interplay between the material characteristics and the optical mode properties plays a key role in defining the modulator performance. Based on physical tradeoffs between index modulation, loss, optical confinement factors and slow‐light effects, we find that there exist combinations of bias, material and optical mode that yield efficient phase or amplitude modulation with acceptable insertion loss. Furthermore, we show how material properties in the epsilon near zero regime enable reduction of length by as much as by 15 times. Lastly, we introduce and apply a cavity‐based electro‐optic modulator figure of merit, Δ λ /Δ α , relating obtainable resonance tuning via phase shifting relative to the incurred losses due to the fundamental Kramers‐Kronig relations suggesting optimized device operating regions with optimized modulation‐to‐loss tradeoffs. This work paves the way for a holistic design rule of electro‐optic modulators for high‐density on‐chip integration.
A Subthreshold Low Phase Noise CMOS LC VCO for Ultra Low Power Applications (2007)

A subthreshold low power, low phase-noise voltage controlled oscillator (VCO) is demonstrated in a commercial 0.18 mum CMOS process. In subthreshold regime, MOS drain current is dominated by diffusion mechanism resulting in a high ratio of transconductance to drain current and suppressed phase noise. Therefore, low power and low phase noise characteristics are achieved without using nonconventional high passive components. The VCO measures a phase noise of -106 dBc/Hz at 400 kHz offset from 2.63 GHz oscillation frequency with 0.43 mW power dissipation drawn from 0.45 V power supply. Figures of merit for this VCO (power-frequency-normalized of 12 dB and power frequency-tuning-normalized of -10 dB) are among the best reported for CMOS oscillators.
Molecular Mechanism of the Excellent Emulsifying Properties of Phosvitin−Galactomannan Conjugate (1999)

The emulsifying properties of native and N- and C-terminal-deleted phosvitin (protease digests) were compared after conjugation with galactomannan. The emulsifying properties of Maillard-type phosvitin-galactomannan conjugates were greatly improved, whereas those of the protease-digested phosvitin-galactomannan conjugates were not so dramatically improved. Phosvitin was highly glycosylated with galactomannan, whereas the protease-digested phosvitin conjugate consisting of a highly phosphorylated core peptide fragment was not. The results suggest that both N and C termini of the peptide moiety, digested by protease, were essential for the improvement of emulsifying properties of phosvitin-galactomannan conjugates. In addition, the role of N and C termini as anchors in oil droplets was supported from the comparative studies of native phosvitin, phosvitin-galactomannan conjugates, and protease-digested phosvitin-galactomannan conjugates.
Endogenous sugar receptor (lectin) profiles of human retinoblastoma and retinoblast cell lines analyzed by cytological markers, affinity chromatography and neoglycoprotein-targeted photolysis. (1989)

Plant lectins have previously been employed to map the composition of cellular glycoconjugates on retinoblastoma and other tumor cells. To characterize the cellular receptors in protein-carbohydrate interactions, we have applied cytological markers (fluorescent neoglycoproteins) containing common carbohydrate building-blocks to investigate the presence of endogenous carbohydrate-binding proteins in six human retinoblastoma cell lines and one established human retinoblast cell line. The staining patterns showed similar expression of endogenous sugar receptors in all cell lines, with few qualitative differences. However, application of affinity chromatography using resins with immobilized carbohydrates as affinity ligands to isolate sugar receptors (lectins) with binding specificities for beta-D-galactosides, alpha-D-mannosides, alpha-L-fucosides alpha-D-glucosides and to N-acetyl-D-glucosamine and N-acetyl-D-galactosamine, respectively, revealed significant differences between the cell lines, emphasizing the value of complementary biochemical analysis. To demonstrate the practical use of this type of glycobiochemical profiling, selective photodestruction of retinoblastoma cells in vitro was accomplished following incubation with synthetic neoglycoprotein-hematoporphyrin conjugates and subsequent exposure to light. This phototherapeutical approach thus combined the inherent specificity of a neoglycoprotein for a particular cellular phenotype with targeted drug activation.