gebhart/patrepeval huggingface dataset:
Nitric oxide–releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets (2006)

Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAID) are promising chemoprevention agents; unlike conventional NSAIDs, they seem free of appreciable adverse effects, while they retain beneficial activities of their parent compounds. Their effect on colon carcinogenesis using carcinoma formation as an end point is unknown. We assessed the chemopreventive properties of NO-indomethacin (NCX 530) and NO-aspirin (NCX 4016) against azoxymethane-induced colon cancer. Seven-week-old male F344 rats were fed control diet, and 1 week later, rats received two weekly s.c. injections of azoxymethane (15 mg/kg body weight). Two weeks after azoxymethane treatment, rats (48 per group) were fed experimental diets containing NO-indomethacin (0, 40, or 80 ppm), or NO-aspirin (1,500 or 3,000 ppm), representing 40% and 80% of the maximum tolerated dose. All rats were killed 48 weeks after azoxymethane treatment and assessed for colon tumor efficacy and molecular changes in colonic tumors and normally appearing colonic mucosa of different dietary groups. Our results suggest that NO-indomethacin at 40 and 80 ppm and NO-aspirin at 3,000 ppm significantly suppressed both tumor incidence (P < 0.01) and multiplicity (P < 0.001). The degree of inhibition was more pronounced with NO-indomethacin at both dose levels (72% and 76% inhibition) than with NO-aspirin (43% and 67%). NO-indomethacin at 40 and 80 ppm and NO-aspirin at 3,000 ppm significantly inhibited the colon tumors' (P < 0.01 to P < 0.001) total cyclooxygenase (COX), including COX-2 activity (52-75% inhibition) and formation of prostaglandin E2 (PGE2), PGF2alpha, and 6-keto-PGF1alpha, and TxB2 from arachidonic acid (53-77% inhibition). Nitric oxide synthase 2 (NOS-2) activity and beta-catenin expression were suppressed in animals given NO-NSAID. In colonic crypts and tumors of animals fed these two NO-NSAIDs, there was a significant decrease in proliferating cell nuclear antigen labeling when compared with animals fed the control diet. The results of this study provide strong evidence that NO-NSAIDs possess strong inhibitory effect against colon carcinogenesis; their effect is associated with suppression of COX and NOS-2 activities and beta-catenin levels in colon tumors. These results pave the way for the rational design of human clinical trials.
One‐Pot Synthesis of α‐Amino Phosphonates Using Samarium Diiodide as a Catalyst Precursor (2003)

Abstract A simple and efficient preparation of α‐amino phosphonates under relatively mild conditions by the one‐pot reaction of aldehydes with amines and dialkyl phosphites using catalytic amounts of SmI 2 is described. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
In Vitro Characterization and in Vivo Application of a Dual Functional Peptide (2013)

Heparan sulfate (HS), one kind of sulfated glycosaminoglycans (GAGs), plays an important role in growth factor-receptor interaction, thereby involving in growth, angiogenesis and innate immune signaling. It is also highly addressed that GAGs and their anchoring core proteins are abnormally expressed in various cancers including lung, liver, and colon cancers. Human ribonuclease A (RNaseA) family members, hRNase2, hRNase3 and hRNase5 are reported to bind to cell surface by recognition of sulfated GAGs. We have recently identified three functionally important HS and heparin binding regions in hRNase3, also named as human eosinophil cationic protein (ECP), and characterized a dual-functional peptide (CPPecp) with GAG-binding and cell-penetrating activities. Screening of in vitro binding activity on various gastrointestinal cell lines demonstrated that CPPecp bound to cells rich in HS on the cell surface. However, cellular binding activity of FITC-CPPecp was abolished while cell surface HS was removed by haparinase treatment. In order to characterize the specific binding of CPPecp, quantitative assay was carried out to precisely decipher binding affinity between CPPecp and a variety of GAGs. In addition, magnetic nanoparticle (Fe3O4)-conjugated CPPecp (MNP-CPPecp) was synthesized as a novel bioprobe to evaluate its feasibility in in vivo magnetic resonance imaging (MRI) analysis in colon tumor mouse model. Taken together, our CPPecp in vitro preferred to bind to sulfated GAGs and selectively attach to HS on cell surface. Moreover, CPPecp demonstrated in vivo tumor targeting activity in colon tumor mouse model, suggesting that CPPecp possesses high potential to be developed as a novel molecular imaging agent and cancer targeting delivery vector.
Social Cohesion and the Sustainable Welfare Society (2008)

Social cohesion is am ambiguous and often contested construct which needs to be pinned down in order to be effectively studied. This paper begins with an overview of its different meanings and of its relationship with other constructs such as social capital and social integration. Then the role of social cohesion in different approaches to quality of life is investigated before engaging in a detailed discussion of social cohesion as a conditional factor of social quality. Within a social quality context, social cohesion is defined as the nature of social relations based on shared identities, values and norms. Social cohesion refers to solidarity as the basis for collective identities and concerns the processes that create, defend or demolish social networks and the social infrastructures underpinning these networks. Its domains are: trust; other integrative norms and values; social networks; and identity. In a recent EU study these were disaggregated into eight sub-domains and twenty indicators. A challenge for the development and empirical application of social quality is to identify whether these indicators are equally relevant in an Asian context. The next stage is to relate social cohesion to the notion of a sustainable welfare society and to sustainability more widely, in terms of social, economic and environmental sustainability. These different facets of sustainability are first defined and then their potential relationship with social cohesion, both holistic and in terms of its components, is explored. Finally some conclusions are drawn about the overall social quality and quality of life contexts of these interrelationships.
A Language-Action Approach to Electronic Negotiations (2005)

The current state-of-the-art in electronic negotiations shows a focus on the trade of standardised mostly inexpensive products in fixed networks of suppliers and customers. To overcome these shortcomings, the goal must be to enable the trade of complex and valuable goods and to support many-to-many marketplace for that purpose. Once valuable goods are concerned, the trade process involves negotiations which consist of a number of communicative exchanges. The Language-Action Perspective has proved to be relevant for the analysis and modelling of communication acts. We will show that a LAP approach is indeed useful as the basis for complex negotiations but only if combined with other theoretical and conceptual foundations.
Mining EST databases to resolve evolutionary events in major crop species (2004)

Using plant EST collections, we obtained 1392 potential gene duplicates across 8 plant species: Zea mays, Oryza sativa, Sorghum bicolor, Hordeum vulgare, Solanum tuberosum, Lycopersicon esculentum, Medicago truncatula, and Glycine max. We estimated the synonymous and nonsynonymous distances between each gene pair and identified two to three mixtures of normal distributions corresponding to one to three rounds of genome duplication in each species. Within the Poaceae, we found a conserved duplication event among all four species that occurred approximately 50-60 million years ago (Mya); an event that probably occurred before the major radiation of the grasses. In the Solanaceae, we found evidence for a conserved duplication event approximately 50-52 Mya. A duplication in soybean occurred approximately 44 Mya and a duplication in Medicago about 58 Mya. Comparing synonymous and nonsynonymous distances allowed us to determine that most duplicate gene pairs are under purifying, negative selection. We calculated Pearson's correlation coefficients to provide us with a measure of how gene expression patterns have changed between duplicate pairs, and compared this across evolutionary distances. This analysis showed that some duplicates seemed to retain expression patterns between pairs, whereas others showed uncorrelated expression.
Lateral complementary transistor structure for the simultaneous fabrication of functional blocks (1964)

Heretofore, the schemes for fabricating a complementary transistor structure in a monolithic functional block entailed either some additional, difficult-to-control processing steps or a sacrifice in isolation of the collector regions of one type of transistor. This paper describes an isolated p-n-p transistor structure fabricated by the same technique used for the conventional all n-p-n transistor functional block without any additional processing steps. The basic p-n-p transistor has a lateral structure. During the p-type base diffusion of the n-p-n transistor, two concentric p-type regions at close distance are selectively diffused into an isolated n- type region such as that used for the collector of an n-p-n transistor. The center p-type diffused region forms the emitter and the outer ring forms the collector. The n-type spacing between these two regions serves as the base. The current gain of this transistor is not high, typically around unity. However, by amplifying the collector current of the p-n-p transistor with an n-p-n transistor, the composite transistor acts like a high gain p-n-p transistor and the composite current gain can be made comparable to that of the n-p-n transistor in the same functional block. The lateral complementary transistor has been used extensively and successfully for the fabrication of linear functional blocks such as those used in the Advanced Minuteman Program.
Serologic Evidence of a Natural Infection of White-Tailed Deer with the Agent of Human Granulocytic Ehrlichiosis in Wisconsin and Maryland (1998)

White-tailed deer participate in the maintenance of the Ixodes tick life cycle and are reservoirs for some tick-borne infectious agents. Deer may be useful sentinels for tick-transmitted agents, such as ehrlichiae. In order to determine whether white-tailed deer are markers of natural transmission or are reservoirs for the human granulocytic ehrlichiosis (HGE) agent, we performed indirect immunofluorescent-antibody (IFA) tests and immunoblotting with the HGE agent and Ehrlichia chaffeensis on sera from 43 and 294 deer captured in northwest Wisconsin during 1994 and 1995, respectively, and 12 deer from southern Maryland. According to IFA testing, 47% of 1994 Wisconsin sera, 60% of 1995 Wisconsin sera, and 25% of Maryland sera contained HGE agent antibodies. All IFA-positive deer sera tested reacted with the 44-kDa band which is unique to the Ehrlichia phagocytophila group. Serologic reactions to E. chaffeensis were detected by IFA testing in 15 of 337 (4%) Wisconsin deer and in 10 of 12 (83%) Maryland deer, while 60 and 80% of E. chaffeensis IFA-positive Wisconsin and Maryland deer sera, respectively, reacted with the E. chaffeensis 28- to 29-kDa antigens by immunoblotting. A total of 4% of deer from Wisconsin and 25% of deer from Maryland were found by IFA testing to have antibodies to both the HGE agent and E. chaffeensis; 75% of these were confirmed to contain E. chaffeensis antibodies by immunoblotting. These results suggest that white-tailed deer in diverse geographical regions of the United States are naturally infected with the HGE agent, E. chaffeensis, or both and that these animals, and potentially humans, are exposed to infected ticks at a high frequency in nature.
Liquid helium level meter by audio-sound detection (1989)

A new audible-liquid-helium level detector using the thermal oscillations of helium gas has been developed. A liquid level can be easily detected by a clear sound change of a vibrating plastic film which is fixed on top of a stainless-steel tube. This level meter is very simple, but more convenient and economical compared with commercial electronic types of level meters.
Synthesis of highly refractive poly(phenylene thioether)s containing a binaphthyl or diphenylfluorene unit (2012)

High refractive index poly(phenylene thioether)s (PPTs) with good solubilities were developed by introducing binaphthyl or diphenylfluorene units. They were prepared by the polycondensation of dithiols, 2,7-thianthrenedithiol and 9,9-bis(4-sulfanylphenyl)fluorene, with difluoro compounds, 4,4′-difluoro-1,1′-binaphthyl and 2,7-difluorothianthrene. The bulky and non-planar structures of the PPTs endow good solubilities in several organic solvents, such as 1,1,2,2-tetrachloroethane (TCE), N-methylpyrrolidone (NMP), and N,N′-dimethylpropyleneurea (DMPU). They exhibit a high thermal stability, that is, 5% weight loss temperatures of 483 and 494 °C under nitrogen, and glass transition temperatures of 235 and 237 °C, respectively, reflecting the rigid structures of the diphenylfluorene or binaphthyl unit. They also exhibit a good transparency in the visible region (transmittance > 85% at 400 nm) and high refractive indices of 1.776 and 1.737, and low birefringences of 0.0049 and 0.0035, respectively. The PPTs with a high thermal stability and good optical properties should be good candidates for optical applications.
Investigation of Dynamic Threshold Voltage Behavior in Semi-Floating Gate Transistor for Normally-Off AlGaN/GaN HEMT (2017)

In this paper, an inverter composed of semi-floating gate (SFG) transistor and a load resistor was analyzed. Varying threshold voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> ) during switching was observed. This dynamic V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> behavior of SFG device is because of the special device structure of SFG transistors. Based on the V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> -programmable behavior of the SFG transistor, a SFG-based GaN high electron mobility transistor was proposed and enhancement-mode was realized with writing-0 into the transistor during every switching operation by simulation.
CD4<sup>+</sup>CD25<sup>+</sup> T cells regulate the intensity of hypersensitivity responses to peanut, but are not decisive in the induction of oral sensitization (2007)

These results indicate that CD4+CD25+ Tregs are involved in maintaining tolerance to oral antigens and regulate the intensity of an IgE-mediated food hypersensitivity response, but are not crucial in preventing sensitization. Accordingly, CD4+CD25+ Tregs may represent a potential tool for the treatment of food allergic disorders.
Analysis and synthesis of suspended and inverted microstrip lines (1985)

Background: Acute postoperative delirium is the most common neuropsychiatric disorder in cardiac surgery patients in the intensive care unit (ICU). The purpose of this study was to evaluate the possible risk factors of postoperative delirium (POD) for cardiac surgery patients in the ICU. Materials and Methods: The study population was composed of 86 cardiac surgery patients managed postoperatively in the cardiac surgery ICU. Presence of POD in patients was evaluated by the CAM-ICU scale. Results: According to the CAM-ICU scale, 22 (25.6%) patients presented POD; history of smoking, alcohol use, COPD, and preoperative permanent atrial fibrillation were associated with POD (for all, p < 0.05). The type of cardiac surgery operations, type of analgesia, and red blood cell transfusion in the ICU were not associated with POD (p > 0.05), while cardiac arrhythmia in the ICU, hypoxemia in the ICU after extubation (pO2 < 60 mmHg), and heart rate after extubation were predisposing factors for POD (for all, p < 0.05). Multivariable logistic regression analysis (adjusted to risk factors) showed that hypoxemia after extubation (OR = 20.6; 95%CI: 2.82−150), heart rate after extubation (OR = 0.95; 95% CI: 0.92−0.98), and alcohol use (OR = 74.3; 95%CI: 6.41−861) were predictive factors for acute postoperative delirium (for all, p < 0.05). Conclusion: Alcohol use and respiratory dysfunction before and after heart operation were associated with acute postoperative delirium in cardiac surgery ICU patients.
Design and application of a plasma impedance monitor for RF plasma diagnostics (2000)

This thesis presents the design and application of a Plasma\nImpedance Monitor (PIM) as a plasma diagnostic for use with RF plasmas, focusing on its potential use in the semiconductor manufacturing industry. The plasma impedance monitor system was designed to measure the amplitude and phase of the first five Fourier components (harmonics) of the plasma voltage and current of RF plasma process reactors.\n\nThe first two chapters of this thesis discuss Plasma and Plasma Process Reactors as commonly used in the manufacture of semiconductors. The most important parameters of a plasma in terms of materials processing are introduced as are the most common types of plasma process reactors and their characteristics.\n\nChapters 3 and 4 discuss the PIM hardware and its method of\ncalibration In chapter 3, the RF sensor and waveform sampling card, known as the IV Sensor and RF Vector Integrator respectively, are discussed in detail. The technique of measuring the RF voltage and current using the IV Sensor and the unique waveform sampling technique used by the sampling card are explained. In chapter 4, the method of calibration for the IV Sensor and RF Vector Integrator are explained. Finally, the use of a Dynamic Dummy Load (DDL) to test the performance of the system is shown.\n\nChapter 5 demonstrates the measurement repeatability and\nresolution of the PIM as used with a commercial plasma process reactor. In chapter 6 some applications of the PIM for use in the semiconductor manufacturing industry are explained and demonstrated.\n\nAs the manufacture of integrated circuits becomes more complex due to the reduction in component size, improved control of the manufacturing processes becomes essential. Present day plasma processing tools provide real-time information such as RF power, chamber pressure, temperature, gas flow rate and gas composition that are used to control the process. However, the reduction in device geometry, the need for higher yield, and the high cost of equipment ownership means that engineers require tighter control of the process and must be able to diagnose process and machine faults quickly and efficiently.\n\nPlasma-based processing systems can be characterised by their RF electrical parameters and it has been shown that changes in process conditions such as RF power or matching efficiency can be correlated to variability in process results and wafer quality. The use of a plasma impedance monitor to measure and control the electrical properties of the RF discharge, and ultimately detect or predict process faults, can therefore become a most valuable process diagnostic.
Altered Na<sup>+</sup>-K<sup>+</sup>pump activity and plasma lipids in salt-hypertensive Dahl rats: relationship to<i>Atp1a1</i>gene (2001)

A genetic variant of the gene for the alpha(1)-isoform of Na(+)-K(+)-ATPase (Atp1a1) was suggested to be involved in the pathogenesis of salt hypertension in Dahl rats through altered Na(+):K(+) coupling ratio. We studied Na(+)-K(+) pump activity in erythrocytes of Dahl salt-sensitive (SS/Jr) rats in relation to plasma lipids and blood pressure (BP) and the linkage of polymorphic microsatellite marker D2Arb18 (located within intron 1 and exon 2 of Atp1a1 gene) with various phenotypes in 130 SS/Jr x SR/Jr F(2) rats. Salt-hypertensive SS/Jr rats had higher erythrocyte Na(+) content, enhanced ouabain-sensitive (OS) Na(+) and Rb(+) transport, and higher Na(+):Rb(+) coupling ratio of the Na(+)-K(+) pump. BP of F(2) hybrids correlated with erythrocyte Na(+) content, OS Na(+) extrusion, and OS Na(+):Rb(+) coupling ratio, but not with OS Rb(+) uptake. In F(2) hybrids there was a significant association indicating suggestive linkage (P < 0.005, LOD score 2.5) of an intragenic marker D2Arb18 with pulse pressure but not with mean arterial pressure or any parameter of Na(+)-K(+) pump activity (including its Na(+):Rb(+) coupling ratio). In contrast, plasma cholesterol, which was elevated in salt-hypertensive Dahl rats and which correlated with BP in F(2) hybrids, was also positively associated with OS Na(+) extrusion. The abnormal Na(+):K(+) stoichiometry of the Na(+)-K(+) pump is a consequence of elevated erythrocyte Na(+) content and suppressed OS Rb(+):K(+) exchange. In conclusion, abnormal cholesterol metabolism but not the Atp1a1 gene locus might represent an important factor for both high BP and altered Na(+)-K(+) pump function in salt-hypertensive Dahl rats.
Using Mobile Phones to Nurture Social Networks (2010)

Novel technologies for nurturing a person's contacts use mobile phones to recommend new friends or track a friendship's health. Such monitoring can also help people monitor their own emotions.
Cardiac Glycosides and Aglycones by Synthesis and Microbiological Conversion<sup>1a</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCardiac Glycosides and Aglycones by Synthesis and Microbiological Conversion1aFrancis G. Henderson and K. K. ChenCite this: J. Med. Chem. 1965, 8, 5, 577–579Publication Date (Print):September 1, 1965Publication History Published online1 May 2002Published inissue 1 September 1965https://pubs.acs.org/doi/10.1021/jm00329a006https://doi.org/10.1021/jm00329a006research-articleACS PublicationsRequest reuse permissionsArticle Views138Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts