gebhart/patrepeval huggingface dataset:
CLEFT LIP (2000)

Abstracts Office: Anne Natvig Managing Abstracts Editor 2115 Nature Cove, No. 107 Ann Arbor, Mich. 48104 MEMBERS OF THE BOARD OF REVIEWERS United States and Canada David B. Apfelberg, Atherton, Calif. L. Leslie Bolton, Long Beach, Calif. H. Hollis Caffee, Gainesville, Fla. Errikos Constant, Lansing, Mich. Robert J. Costarella, Arcadia, Calif. Sharadkumar Dicksheet, Flushing, N.Y. Peter B. Fodor, Los Angeles, Calif. James C. Grotting, Birmingham, Ala. H. Raul Herrera, Rochester, N.Y. John Kucan, Springfield, Ill. Carl H. Manstein, Philadelphia, Pa. Toby R. Meltzer, Portland, Ore. M. A. Mendez-Fernandez, Redding, Calif. Richard A. Mladick, Virginia Beach, Va. Janet M. Neigel, West Orange, N.J. George S. Pap, Rockford, Ill. Gary J. Rosenberg, Delray Beach, Fla. James D. Schlenker, Oak Lawn, Ill. In Chul Song, Brooklyn, N.Y. Ivan M. Turpin, Orange, Calif. Norman Weinzweig, Chicago, Ill. David N. White, Palo Alto, Calif. Peter E. Wyshynski, Waterloo, Ont. Reprint requests to Dr. N. Nakakita, Kitasato University School of Medicine, 1-5-11, Kitasato, Sagamihara, 228, Kanagawa, Japan
Developmental delay in Rett syndrome: data from the natural history study (2014)

This NHS study, clinicaltrials.gov (NCT00296764), represents the largest group of RTT participants assessed repeatedly by direct examination.
Learning relational probability trees (2003)

Classification trees are widely used in the machine learning and data mining communities for modeling propositional data. Recent work has extended this basic paradigm to probability estimation trees. Traditional tree learning algorithms assume that instances in the training data are homogenous and independently distributed. Relational probability trees (RPTs) extend standard probability estimation trees to a relational setting in which data instances are heterogeneous and interdependent. Our algorithm for learning the structure and parameters of an RPT searches over a space of relational features that use aggregation functions (e.g. AVERAGE, MODE, COUNT) to dynamically propositionalize relational data and create binary splits within the RPT. Previous work has identified a number of statistical biases due to characteristics of relational data such as autocorrelation and degree disparity. The RPT algorithm uses a novel form of randomization test to adjust for these biases. On a variety of relational learning tasks, RPTs built using randomization tests are significantly smaller than other models and achieve equivalent, or better, performance.
Smart cards--a security tool for health information systems. (1994)

Expanding use of information technology in health care, both within and between the institutions, leads to additional security demands. The role is discussed that can be played by smart cards for healthcare professionals.
A Frame Rate Conversion Method Based on a Virtual Shutter Angle (2019)

In this paper a new method for frame rate conversion is presented. Utilising motion compensated frame prediction, our method mitigates the spatial distortions associated with traditional methods, while facilitating the conversion between a wider range of frame rates - useful when converting to/between legacy video formats. Using the concept of a virtual shutter angle, our method provides content providers with greater flexibility over the motion characteristic of their video sequences. We also propose a Gaussian weighting scheme which attempts to emulate a video sequence as if it was captured natively at the converted frame rate. A subjective experiment which compared our method to averaging frames at a range of frame rates, has shown that our method results in significantly higher visual quality across a range of content - especially for high down-sample factors.
Spin-polarized charge trapping cell based on a topological insulator quantum dot (2017)

We demonstrate theoretically that a topological insulator quantum dot can be formed <italic>via</italic> double topological insulator constrictions (TICs), and can be used as a charge and/or spin carrier trap memory element.
Antitumor Effect of NK012, a 7-Ethyl-10-Hydroxycamptothecin–Incorporating Polymeric Micelle, on U87MG Orthotopic Glioblastoma in Mice Compared with Irinotecan Hydrochloride in Combination with Bevacizumab (2010)

The present study using orthotopic glioblastoma model in mice may warrant further preclinical evaluation of NK012 before conducting the clinical trial of the drug, because the antitumor activity of NK012 monotherapy was superior to the combination therapy of CPT-11 with bevacizumab.
Real-time monitoring of benzene, toluene, and p-xylene in a photoreaction chamber with a tunable mid-infrared laser and ultraviolet differential optical absorption spectroscopy (2011)

We describe the implementation of a mid-infrared laser-based trace gas sensor with a photoreaction chamber, used for reproducing chemical transformations of benzene, toluene, and p-xylene (BTX) gases that may occur in the atmosphere. The system performance was assessed in the presence of photoreaction products including aerosol particles. A mid-infrared external cavity quantum cascade laser (EC-QCL)-tunable from 9.41-9.88 μm (1012-1063 cm(-1))-was used to monitor gas phase concentrations of BTX simultaneously and in real time during chemical processing of these compounds with hydroxyl radicals in a photoreaction chamber. Results are compared to concurrent measurements using ultraviolet differential optical absorption spectroscopy (UV DOAS). The EC-QCL based system provides quantitation limits of approximately 200, 200, and 600 parts in 10(9) (ppb) for benzene, toluene, and p-xylene, respectively, which represents a significant improvement over our previous work with this laser system. Correspondingly, we observe the best agreement between the EC-QCL measurements and the UV DOAS measurements with benzene, followed by toluene, then p-xylene. Although BTX gas-detection limits are not as low for the EC-QCL system as for UV DOAS, an unidentified by-product of the photoreactions was observed with the EC-QCL, but not with the UV DOAS system.
Photography for entomologists (1906)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Supporting Environment Configuration with Generic Role Assignment (2011)

Due to the fact that distant objects are often less relevant to an application than objects in the proximity, middleware systems for pervasive computing typically exploit locality to improve efficiency. To do this, they configure the environment by introducing logical boundaries that reduce the number of interacting devices. Yet, in cases where applications require the interaction with distant objects, the boundaries become an artificial barrier that must be overcome by supplemental mechanisms. In this paper, we show how this problem can be avoided by using role assignment as a generic mechanism for environment configuration. To do this, we first derive the requirements for configuring a pervasive computing environment. We discuss how these requirements can be met by means of role assignment. To evaluate the approach, we present a prototypical implementation which we use to quantify the resulting overheads. The results indicate that role assignment enables a more flexible definition of boundaries at a low cost.
Full duplex techniques for 5G networks: self-interference cancellation, protocol design, and relay selection (2015)

The wireless research community aspires to conceive full duplex operation by supporting concurrent transmission and reception in a single time/frequency channel for the sake of improving the attainable spectral efficiency by a factor of two as compared to the family of conventional half duplex wireless systems. The main challenge encountered in implementing FD wireless devices is that of finding techniques for mitigating the performance degradation imposed by self-interference. In this article, we investigate the potential FD techniques, including passive suppression, active analog cancellation, and active digital cancellation, and highlight their pros and cons. Furthermore, the troubles of FD medium access control protocol design are discussed for addressing the problems such as the resultant end-to-end delay and network congestion. Additionally, an opportunistic decode-and-forward- based relay selection scheme is analyzed in underlay cognitive networks communicating over independent and identically distributed Rayleigh and Nakagami-m fading channels in the context of FD relaying. We demonstrate that the outage probability of multi-relay cooperative communication links can be substantially reduced. Finally, we discuss the challenges imposed by the aforementioned techniques and a range of critical issues associated with practical FD implementations. It is shown that numerous open challenges, such as efficient SI suppression, high-performance FD MAC-layer protocol design, low power consumption, and hybrid FD/HD designs, have to be tackled before successfully implementing FD-based systems.
Nicotine as an Antiepileptic Agent in ADNFLE: An N‐of‐One Study (2003)

Nicotine patches may be of benefit to some individuals with ADNFLE.
<scp>L</scp>‐Arginine hydrochloride increases the solubility of folded and unfolded recombinant plasminogen activator rPA (2010)

L-arginine hydrochloride (L-ArgHCl) was found to be an effective enhancer for in vitro protein refolding more than two decades ago. A detailed understanding of the mechanism of action, by which L-ArgHCl as co-solvent is capable to effectively suppress protein aggregation, while protein stability is preserved, has remained elusive. Concepts for the effects of co-solvents, which have been established over the last decades, were found to be insufficient to completely explain the effects of L-ArgHCl on protein refolding. In this article, we present data, which clearly establish that L-ArgHCl acts on the equilibrium solubility of the native model protein recombinant plasminogen activator (rPA), while for S-carboxymethylated rPA (IAA-rPA) that served as a model protein for denatured protein states, equilibrium solubilities could not be obtained. Solid to solute free transfer energies for native rPA were lowered by up to 14 kJ mol(-1) under the tested conditions. This finding is in marked contrast to a previously proposed model in which L-ArgHCl acts as a neutral crowder which exclusively has an influence on the stability of the transition state of aggregation. The effects on the apparent solubility of IAA-rPA, as well as on the aggregation kinetics of all studied protein species, that were observed in the present work could tentatively be explained within the framework of a nucleation-aggregation scheme, in which L-ArgHCl exerts a strong effect on the pre-equilibria leading to formation of the aggregation seed.
[Status of the pediatric oncohematologic service in Russia]. (1996)

In spite of the fact that official statistical data show lower cancer morbidity of pediatric population in Russia than in Europe and USA (9.7 against 13.8 and 13.6, respectively), real cancer incidence may be close to mean incidence in Europe and USA as in Moscow it is 14.8 in boys and 12.0 in girls. Lower numbers in some other regions may be attributable to low standards of cancer diagnosis and inadequate case registration. In Moscow where standards of children's hematological service are high the proportion of some malignancies is the following: hemoblastoses-48.5%, CNS tumors-19.8%, neuroblastoma-8.0%, renal tumors-6.5%, sarcomas of soft tissues and bones-2.4 and 4.6%, respectively. The efficacy of anticancer treatment of children in many regions of Russia is poor, but the situation may be changed for the best by introduction of new approaches developed in the Moscow Research Institute of Pediatric Hematology.
Histone tail cleavage as a novel epigenetic regulatory mechanism for gene expression (2018)

Chromatin is an intelligent building block that can express either external or internal needs through structural changes. To date, three methods to change chromatin structure and regulate gene expression have been well-documented: histone modification, histone exchange, and ATP-dependent chromatin remodeling. Recently, a growing body of literature has suggested that histone tail cleavage is related to various cellular processes including stem cell differentiation, osteoclast differentiation, granulocyte differentiation, mammary gland differentiation, viral infection, aging, and yeast sporulation. Although the underlying mechanisms suggesting how histone cleavage affects gene expression in view of chromatin structure are only beginning to be understood, it is clear that this process is a novel transcriptional epigenetic mechanism involving chromatin dynamics. In this review, we describe the functional properties of the known histone tail cleavage with its proteolytic enzymes, discuss how histone cleavage impacts gene expression, and present future directions for this area of study. [BMB Reports 2018; 51(5): 211-218].
Integrated Motion Detection and Tracking for Visual Surveillance (2006)

Visual surveillance systems have gained a lot of interest in the last few years. In this paper, we present a visual surveillance system that is based on the integration of motion detection and visual tracking to achieve better performance. Motion detection is achieved using an algorithm that combines temporal variance with background modeling methods. The tracking algorithm combines motion and appearance information into an appearance model and uses a particle filter framework for tracking the object in subsequent frames. The systems was tested on a large ground-truthed data set containing hundreds of color and FLIR image sequences. A performance evaluation for the system was performed and the average evaluation results are reported in this paper.
Consequences of increased systolic blood pressure in patients with osteoarthritis and rheumatoid arthritis. (2003)

Relatively small changes in SBP associated with use of common arthritis medications can have a significant effect on the cardiovascular risk profile. It is important that clinicians who treat patients with OA/RA accurately weigh the potential risks of these medications against their benefits.
Extremely low threshold-current-density InGaAs quantum-well lasers with emission wavelength of 1215–1233 nm (2003)

Extremely low threshold-current-density In0.4Ga0.6As quantum-well (QW) lasers have been realized in the 1215–1233 nm wavelength regime. The measured room-temperature threshold current density of the InGaAs QW lasers with a cavity length of 1000 μm is only 90 A/cm2 at an emission wavelength of 1233 nm.
Diagnosis of Hair Disorders (2009)

Hair disorders include hair loss, increased hair growth, and hair structure defects with increased breakage, as well as unacceptable cosmetic appearance, such as reduced shine, strength, curliness, and elasticity. It is the task of the dermatologist to choose the right diagnostic tool depending on the suspected clinical diagnosis. Moreover, certain tools are best suited for diagnosis in private practice, whereas others can only be used to monitor hair growth under treatment in clinical studies. The techniques can be classified as either invasive (eg, biopsies in scarring alopecia), semi-invasive (trichogram, unit area trichogram), or noninvasive (eg, global hair counts, phototrichogram, electron microscopy, laser scanning microscopy) methods. Further, one must differentiate between subjective and objective techniques. For the practicing dermatologist, body and scalp hair distribution by use of different grading systems, the hair pull test, and dermoscopy belong in the category of basic diagnostic tools. Basic techniques may be extended by computer-assisted phototrichogram and, in selected cases, by use of the trichogram and/or scalp biopsies. For research purposes optical coherent tomography, electron microscopy, biochemical methods, atomic force microscopy, and confocal laser scanning microscopy are optional tools. For clinical studies global photographs (global expert panel), hair weighing, phototrichogram, and different clinical scoring systems have proven to be objective tools for documentation and evaluation of hair growth and hair quality.
One-Pot Synthesis of 2,3-Dihydro-pyrrolopyridinones Using in Situ Generated Formimines (2006)

International audience
Disulfiram, a drug widely used to control alcoholism, suppresses self-renewal of glioblastoma and overrides resistance to temozolomide (2012)

Glioblastomas (GBM) are associated with high rates of relapse. These brain tumors are often resistant to chemotherapies like temozolomide (TMZ) and there are very few treatment options available to patients. We recently reported that polo-like kinase-1 (PLK1) is associated with the proliferative subtype of GBM; which has the worst prognosis. In this study, we addressed the potential of repurposing disulfiram (DSF), a drug widely used to control alcoholism for the past six decades. DSF has good safety profiles and penetrates the blood-brain barrier. Here we report that DSF inhibited the growth of TMZ resistant GBM cells, (IC90=100 nM), but did not affect normal human astrocytes. At similar DSF concentrations, self-renewal was blocked by ~100% using neurosphere growth assays. Likewise the drug completely inhibited the self-renewal of the BT74 and GBM4 primary cell lines. Additionally, DSF suppressed growth and self-renewal of primary cells from two GBM tumors.These cells were resistant to TMZ, had unmethylated MGMT, and expressed high levels of PLK1. Consistent with its role in suppressing GBM growth, DSF inhibited the expression of PLK1 in GBM cells. Likewise, PLK1 inhibition with siRNA, or small molecules (BI-2536 or BI-6727) blocked growth of TMZ resistant cells. Our studies suggest that DSF has the potential to be repurposed for treatment of refractory GBM.
Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation (1988)

We have mapped the termini and determined the relative abundance and ribosome density of the major cytoplasmic transcript of the DNA polymerase (pol) gene of herpes simplex virus type 1. Nuclease protection and primer extension analyses located the 5' end of the major pol transcript at two closely spaced sites 51 and 57 nucleotides to the left of a BamHI site at map position 0.413. S1-sensitive sites corresponding to additional minor transcripts were found to map further upstream within a palindromic sequence that contains a viral replication origin. The major 3' end was found to map 90 nucleotides upstream of a KpnI site at map position 0.439. Quantitative S1 nuclease assays revealed that pol transcripts were nearly as abundant as transcripts encoded by the viral thymidine kinase gene. However, relatively few pol transcripts were found on large polysomes at 5.5 h after infection, when pol transcripts were most abundant. This was in marked contrast to the polyribosome distribution of transcripts from the thymidine kinase gene and the major DNA-binding protein gene. These results and sequence features of the pol transcript suggest that pol expression is regulated, in part, at the level of translation.
Optimal Timing Strategies for Controlled <i>M/G/1</i> Queueing System via Diffusion Approximation Approach (1997)

In this paper, we consider the optimal timing strategies for a controlled single-server M/G/1 queueing system. The expected total discounted costs are formulated under two timing strategies and approximated by means of the diffusion approximation method. Numerical calculations are devoted to examine the accuracy of the approximation method. The results show that the diffusion approximation method is reasonably good for the typical queueing systems, especially, the M/M/1 single-server queue.
Reactions of alkenes and the equilibration of hydrogen and deuterium on zirconia (1987)

The hydrogenation of various alkenes, the equilibration of H2/D2 and the isomerisation of some C6-alkenes have been studied over a range of temperatures on zirconia catalysts. Products from the reaction of some of the alkenes with deuterium were examined by 2D n.m.r. spectroscopy. The rate of hydrogenation varied only to a small extent with the nature of the alkene, apart from some steric hindrance with some of the C6-compounds, and the supply of hydrogen to the surface appeared to be rate-determining. Reactions of alkenes with deuterium below 400 K gave D2-alkanes. As the temperature was raised, exchange of alkene was observed to an increasing extent, and the location of the deuterium atoms in the products provided evidence of possible mechanisms.
Past, Present, and Future of Real-Time Embedded Automotive Software: A Close Look at Basic Concepts of AUTOSAR (2006)

<div class="htmlview paragraph">Real-time embedded automotive software has traditionally been tightly coupled with the hardware on which it runs. In the automotive ecosystem, OEMs and their suppliers are involved in various aspects of developing embedded software. In some instances, suppliers provide the embedded software together with the hardware. In other instances, suppliers provide hardware and infrastructure software, while the OEM takes charge of developing the Application Layer. OEMs typically have the responsibility of integrating the software. Either model can derive value from a non ECU-centric approach to designing the application software, as such an approach allows OEMs to add new software components to existing software packages whenever necessary. The AUTOSAR initiative was created on the value proposition portable application software provides. As ECU development most often starts with legacy software, this paper presents the challenges and benefits of remapping an existing application to work under AUTOSAR.</div>
Integration of 3D audio and 3D video for FTV (2009)

We developed an FTV system to process, and display information of 3D scene in realtime, in which users freely control their own viewpoint/listening-point position. Free listening-point can be generated by either (i) ray-space representation of sound wave field (source sound independent), or (ii) by acoustic transfer function estimation (source sound dependent) and blind separation of sources of sounds. Free viewpoint generation is based on ray-space method, which is enhanced by using multipass dynamic programming. Integration is done by either (i) ray-space representation of sound wave and images together, or (ii) integrating each camera video signal and acoustic transfer function of the same location as integrated 3DAV data. The prototype system of integrated audio-visual viewer achieves both good image and sound qualities in realtime.
Effect of Nb on Hot Rolled High Strength Steel Sheets Produced by Thin Slab Casting and Hot Direct Rolling Process (2003)

In order to meet to the demands from automobile industry such as weight reduction and safety improvement, the hot rolled high strength steel sheets have been used mainly for suspension parts. While, the steel production by thin slab casting (TSC) and hot direct rolling (HDR) process has been noticed. In this study, the characteristics of the high strength hot rolled steels produced by TSC-HDR were discussed comparing with the conventional process and concluded as follows;(1) The effect of difference of production route on the relationship between tensile strength and elongation or tensile strength and stretch flangeability was small.(2) Strength obtained by TSC-HDR route was higher than those of conventional production route in Nb bearing steel. This means Nb effectively works as a strengthening element in TSC-HDR route.(3) The addition of Nb and Mn was effective on the improvement of tensile strength and stretch flangeabilty relationship. Especially when the stretch flangeabilty was compared in the same TS level, Nb bearing steels exhibited more than two times of the value of plain C-Mn steel.