gebhart/patrepeval huggingface dataset:
Individual Foods and Food Group Patterns of the Oldest Old (1997)

Abstract This study compares the dietary patterns of centenarians (n = 73) with sexagenarians (n = 76) and octogenarians (n = 83). A Daily Diet Diary was developed to code the responses of the 24-hour dietary recalls. Centenarians and octogenarians had higher consumption frequencies of milk (P < 0.001) and grains (P < 0.01) and fewer (P < 0.05) skipped breakfasts than sexagenarians. However, centenarians also consumed high fat foods, such as whole milk (P < 0.001) and biscuits (P < 0.01), and coffee (P < 0.05) more frequently than the two younger cohorts. Several of the variations found in the food patterns among the three age groups may reflect cohort differences, rather than true antecedents for longevity.
Up-Regulation of IL-10R1 Expression Is Required to Render Human Neutrophils Fully Responsive to IL-10 (2001)

We have recently shown that IL-10 fails to trigger Stat3 and Stat1 tyrosine phosphorylation in freshly isolated human neutrophils. In this study, we report that IL-10 can nonetheless induce Stat3 tyrosine phosphorylation and the binding of Stat1 and Stat3 to the IFN-gamma response region or the high-affinity synthetic derivative of the c-sis-inducible element in neutrophils that have been cultured for at least 3 h with LPS. Similarly, the ability of IL-10 to up-regulate suppressor of cytokine signaling (SOCS)-3 mRNA was dramatically enhanced in cultured neutrophils and, as a result, translated into the SOCS-3 protein. Since neutrophils' acquisition of responsiveness to IL-10 required de novo protein synthesis, we assessed whether expression of IL-10R1 or IL-10R2 was modulated in cultured neutrophils. We detected constitutive IL-10R1 mRNA and protein expression in circulating neutrophils, at levels which were much lower than those observed in autologous monocytes or lymphocytes. In contrast, IL-10R2 expression was comparable in both cell types. However, IL-10R1 (but not IL-10R2) mRNA and protein expression was substantially increased in neutrophils stimulated by LPS. The ability of IL-10 to activate Stat3 tyrosine phosphorylation and SOCS-3 synthesis and to regulate IL-1 receptor antagonist and macrophage-inflammatory protein 1beta release in LPS-treated neutrophils correlated with this increased IL-10R1 expression, and was abolished by neutralizing anti-IL-10R1 and anti-IL-10R2 Abs. Our results demonstrate that the capacity of neutrophils to respond to IL-10, as assessed by Stat3 tyrosine phosphorylation, SOCS-3 expression, and modulation of cytokine production, is very dependent on the level of expression of IL-10R1.
Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity (2017)

Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever screened for dengue by RT-PCR or NS1 antigen testing was performed. Patients were assessed daily while symptomatic and at convalescence. Serum hyaluronic acid (HA), heparan sulfate (HS) and selected cytokines (TNF-α, IL-6, IL-10) were measured on enrollment and convalescence. Patients were diagnosed as dengue fever (DF, n = 30), dengue hemorrhagic fever (DHF, n = 20) and non-dengue (ND) febrile illness (n = 11). Acute HA and HS levels were significantly higher in all dengue patients compared to ND (p = 0.0033 and p = 0.0441 respectively), but not different between DF and DHF (p = 0.3426 and p = 0.9180 respectively). Enrolment HA inversely correlated with serum albumin, protein and platelets in all dengue and DHF (p < 0.05). HA and HS in all dengue patients decreased significantly at convalescence. Serum IL-10 was significantly associated with HA in all dengue patients (p = 0.002). Serum HA and HS levels were increased in adult dengue and HA was associated with markers of disease severity. Endothelial glycocalyx damage may have a role in vascular leakage in dengue.
Holographic substrate-guided spectrometer for atmospheric sensing (2013)

This paper surveys the need for oxygen A-band spectroscopy to improve our understanding of clouds and their key role in the climate system. We then report on a novel holographic A-band substrate-guided spectrometer device recently developed at Luminit. This A-band spectrometer prototype is based on an innovative structure of two thick reflection substrate-guided wave-based holograms (SGWHs) that act as dispersive and/or imaging elements to enable a sufficient spectral resolution. The technology is made very attractive by its significantly lower cost compared to currently available systems/devices with similar A-band capability, while providing higher light throughput, a better out-of-band rejection ratio, higher resolution at a smaller size, and better stability and reliability.
Evaluation of a Fixed Anti-Icing Spray System (1999)

Each year hundreds of automobile drivers have accidents caused by iced-over bridges adjacent to roads that are free from ice. Ice forms on bridges because the ground does not insulate them; therefore, the temperature of a bridge deck rapidly cools to the ambient air temperature, which is often well below freezing. This is particularly evident on the Interstate 215 overpass/exchange at 6200 South Street in Salt Lake City, Utah. This bridge averages more than 24 accidents per winter season because of snow and ice conditions. A system was installed at this location that applied the anti-icing liquid agent magnesium chloride (MgCl 2 ) to the northbound lanes of the freeway bridge deck. The southbound lanes received no additional treatment, other than the efforts of the Utah Department of Transportation’s snow- and ice-removal operators. The anti-icing spray system is parapet-mounted and delivers approximately 360 L/lane-km/spray (95 gal/lane-km/ spray) event of MgCl 2 . The effectiveness of the spray system was analyzed for the 1997 and 1998 winter season. The system reduced the number of accidents caused by snow and ice on the northbound side of the road by 64 percent. The ratio of the number of accidents occurring on the treated northbound side of the road to the number of accidents occurring on the untreated southbound side was reduced from 1.4 to 0.7. The anti-icing system proved effective in reducing the number of accidents that occur on this very dangerous section of roadway in Utah.
PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. (2003)

Our previous work showed that, compared with parental U87MG human glioblastoma cells, vascular endothelial growth factor (VEGF) mRNA levels are decreased in U87/T691, a derivative line in which epidermal growth factor receptor (EGFR) signaling is inhibited by introduction of a truncated p185(Neu) protein (A. Maity et al., Cancer Res., 60: 5879-5886, 2000). The effect of EGFR activation on VEGF was mediated at the level of transcription via a phosphatidylinositol 3'-kinase (PI3K)-dependent pathway. In the current study we investigated the effect of PTEN, a negative regulator of PI3K signaling commonly mutated in glioblastoma cells, on VEGF expression. Several glioblastoma cell lines containing mutant PTEN, including U87MG, U87/T691, and U251MG, were infected with adenovirus expressing wild-type PTEN. This led to a decrease in the levels of both VEGF mRNA and phosphorylated Akt, a marker for PI3K activation. Treatment of U87MG cells with LY294002, a PI3K inhibitor, or cotransfection with a vector expressing wild-type PTEN decreased VEGF promoter activity using reporters containing either 1.5 kb of the promoter or a fragment extending from -88 to +54 bp. Activity of the -88/+54 VEGF promoter was down-regulated by dominant negative Akt and up-regulated by constitutively active myristoylated Akt. Introduction of wild-type PTEN and pharmacological inhibition of EGFR decreased VEGF mRNA expression and VEGF promoter activity in U87MG cells to a greater extent that did either manipulation by itself. Therefore, in human glioblastoma cells, PTEN mutation can cooperate with EGFR activation to increase VEGF mRNA levels by transcriptionally up-regulating the proximal VEGF promoter via the PI3K/Akt pathway.
A Novel, Efficient Synthesis of 3,3-Dimethylindoline (1995)

Abstract The Lewis acid mediated cyclisation of N-methallylacetanilide, followed by hydrolysis to give 3,3-dimethylindoline in excellent yield is described.
Genomic Detection Using Sparsity-inspired Tools (2011)

Genome-based detection methods provide the most conclusive means for establishing the presence of microbial species. A prime example of their use is in the detection of bacterial species, many of which are naturally vital or dangerous to human health, or can be genetically engineered to be so. However, current genomic detection methods are cost-prohibitive and inevitably use unique sensors that are specific to each species to be detected. In this thesis we advocate the use of combinatorial and non-specific identifiers for detection, made possible by exploiting the sparsity inherent in the species detection problem in a clinical or environmental sample. By modifying the sensor design process, we have developed new molecular biology tools with advantages that were not possible in their previous incarnations. Chief among these advantages are a universal species detection platform, the ability to discover unknown species, and the elimination of PCR, an expensive and laborious amplification step prerequisite in every molecular biology detection technique. Finally, we introduce a sparsity-based model for analyzing the millions of raw sequencing reads generated during whole genome sequencing for species detection, and achieve significant reductions in computational speed and high accuracy.
Correlation of serum concentrations of psa‐act complex with total psa in random and serial specimens from patients with bph and prostate cancer (1995)

Abstract The current assays for serum prostate specific antigen (PSA) have failed to produce the same PSA values on the same specimens because of problems with antibody specificity and calibrator preparation. To eliminate these problems, we proposed to replace the current serum PSA assay with an assay specific for the PSA‐ACT (PSA‐α 1 ‐antichymotrypsin) complex in the serum. An assay specific for the PSA‐ACT complex was established using the anti‐PSA antibody to coat the microplate for capturing the PSA complex and anti‐ACT polyclonal antibodies for quantification. There was an excellent correlation between serum concentrations of PSA‐ACT and total PSA, using either the Hybritech calibrator (γ = 0.996) or a serum calibrator prepared in house (γ = 0.993), in random as well as in serial specimens from 14 individual patients. Even though we did not find a gradual increase in the percentage of PSA‐ACT with the increase of total PSA in cancer patients, a slightly higher percentage of free PSA was measured in pooled normal sera (18%) and in pooled sera containing only 12 ng/ml of total PSA (12%), compared to serum pools containing elevated PSA (>100 ng/ml) level, in which most PSA was in the complex form (95%). Therefore, using an assay that specifically measures the PSA‐ACT complex in the serum not only simplifies the preparation of calibrator but eliminates the difficulty of antibody selection, it also allows various assay kits to produce identical PSA values and also improve the test specificity for prostate cancer.©1995 Wiley‐Liss, Inc.
A Phase Rule Study of the System Sodium Stearate–Water. (1940)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTA Phase Rule Study of the System Sodium Stearate–Water.James W. McBain, Robert D. Vold, and Mary FrickCite this: J. Phys. Chem. 1940, 44, 9, 1013–1024Publication Date (Print):September 1, 1940Publication History Published online1 May 2002Published inissue 1 September 1940https://doi.org/10.1021/j150405a001RIGHTS & PERMISSIONSArticle Views422Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (569 KB) Get e-Alerts
Digital Control for Radiation-Hardened Switching Converters in Space (2010)

Single-event hardening solutions for two converter designs with digital control are considered for space radiation environments: 1) a boost converter using static random access memory (SRAM)-based field programmable gate arrays (FPGAs). In this case the hardening approach is based on duplication at both the logic and device levels and on a nondisruptive resynchronization mechanism that ensures the converter operation if single-event functional interrupt occurs. 2) An integrated buck converter that uses redundancy at the register level, as well as modification of the very high speed integrated circuit (VHSIC) hardware description language (VHDL) code. These hardening techniques are validated through experiments and simulations.
Observations of Rotational Switching in Ferrites (1959)

Three mechanisms of flux reversal are proposed for the flux reversal in square-loop ferrites, each mechanism being dominant over a certain region of the switching curve. A coherent rotational model is proposed, and experimental evidence supporting the mode yields the lowest values of switching constants for ferrites reported to date. Details of this work, including studies of several ferrites and of dependence on temperature and ceramic process variables, are to be published.
Development and testing of an improved dosimetry system using a backscatter shielded electronic portal imaging device (2012)

The modified BSS-EPID and associated dose model provide an improved system for dosimetry measurements using EPIDs. Several important limitations of the current hardware and software are addressed by this system.
Overnight salivary caffeine clearance: A liver function test suitable for routine use (1987)

The feasibility of measuring caffeine clearance from saliva (SCl) was assessed in ambulatory patients with liver disease and in a control group, and the results were compared with quantitative liver function tests. For this purpose, the subjects were given 280 mg caffeine p.o. in decaffeinated coffee powder between noon and 4 p.m., and caffeine concentrations were measured in saliva (using an enzyme immunoassay) before bedtime and upon arising. In the cirrhotics (n = 29), SCl was 0.58 +/- S.D. 0.45 ml per min X kg, thus being reduced to approximately one-third of drug-free, nonsmoking controls (1.53 +/- 0.46, n = 18); although patients with noncirrhotic liver disease showed intermediate values (0.95 +/- 0.47), their reduction in SCl was significant (p less than 0.001). SCl was correlated with indocyanine green fractional clearance, galactose elimination capacity and aminopyrine breath test; however, the closest relationship (Rs = 0.80) was observed with the aminopyrine breath test. It is suggested that the measurement of SCl represents a noninvasive and innocuous procedure for quantifying hepatic microsomal function, and is suitable for routine use. Since a.m. saliva concentrations of caffeine are highly correlated (Rs = -0.94) with SCl, further simplification of the test to a single-point measurement appears possible.
Skin wrinkles analysis based on digital image processing (2012)

In this paper, we propose a novel objective approach which utilizes the wrinkles on the lower eyelid image of the human to estimate the corresponding skin aging level. Although the face is a small part of the human body and the lower eyelid occupies only a little area on the human face, it possesses important information for aging level identification owing to its vulnerability and fragility to the outside stimuli. Since the wrinkles are the symbol of the aging, it comes naturally that we would pay most attentions to them. With the help of the techniques of image processing, the proposed skin wrinkle analysis algorithm has achieved fairly good performance.
Associative Learning and Phobias (2013)

Associative learning offers one of the earliest explanations of how phobic reactions to stimuli might be acquired. Conditioning as a model for phobia ®rst arose from a famous demonstration by Watson and Rayner (1920) involving a white rat, a hammer, an iron bar, and a small child. The authors wanted to demonstrate that aversive and avoidant responses could be acquired to a previously neutral stimulus. In their study, a 9-month-old child, Albert B (or little Albert), was tested to see whether he was fearful of various stimuli (including a white rat and the noise made by banging a claw hammer on an iron bar). Watson and Rayner established that Albert was not initially fearful of the rat, but was scared by the noise. Albert was then placed in a room with the rat. Every time he touched the rat, or the rat approached him, an experimenter hit the iron bar with the hammer. After several trials in which the rat was paired with the loud noise, Albert started to display signs of anxiety when the rat was presented alone (i.e., without the noise). The authors did not propose a theory of phobia acquisition on the basis of their ®ndings. However, the implication from this study was that experiencing a neutral stimulus in temporal proximity to some fearinducing or traumatic event could create an excessive, persistent fear (i.e., a phobia) to that stimulus.
COACERVATION, COMPLEX-COACERVATION AND FLOCCULATION (1988)

Abstract The mechanism of coacervation is reexamined in the light of recent studies on the polar (i.e., hydrogen-bonding) components of interfacial Interactions in aqueous media. The differences and similarities between coacervation, complex coacervation and flocculation are outlined and illustrated with a number of examples.
Implications of immersion lithography on 193-nm photoresists (2004)

Immersion lithography has been proposed as a technique to print sub-100nm features using 193nm lithography. The process involves filling the space between the lens fixture of an exposure tool and the photoresist-coated silicon wafer with a liquid. In the case of immersion 193nm lithography, water can serve as that liquid. The immersion option raises questions about how photoresists and water interact. Components of the photoresist could be leached into the water, thus modifying the refractive index of the medium, depositing material on the lens, or altering the solubility switching process of the photoresist. Several phenomena could affect the optical properties of the resist and water and, ultimately, the resolution of the process. To better understand the impact that immersion lithography would have on photoresist performance, a study has been undertaken to measure the amount of resist components that are leached by water from model 193nm photoresists. The components studied were residual casting solvent (propylene glycol methyl ether acetate), the photoacid generator (triphenylsulfonium nonaflate), and the base quencher (triethanolamine). Since it was expected that only a small amount of each material would be leached into the water, <sup>14</sup>C-labeled samples of each resist component were synthesized and added to the 193nm resists. Films of the labeled resists were coated onto a silicon wafer and immersed in water. The water was collected and the film was dissolved in casting solvent and collected. The amount of material leached into the water was determined by radiochemical analysis. Spectroscopic ellipsometry was also used to quantify changes in the optical constants of the resists and the water.
[Protein kinase D3 is involved in negative regulation of MMP-7 in prostate cancer cells]. (2010)

PKD3 may contribute to the malignant progression of prostate cancer cells through negative regulation of MMP-7 expression.
Instrument‐Dependent fluorochrome sensitivity in flow cytometric analyses (1995)

Flow cytometry has become the preferred technique by which critical clinical evaluations are made such as CD4 counts and aneuploid analyses. Mounting concern has arisen over the numerous techniques, reagents, and different flow cytometric employed to determine these data. Several studies have documented significant differences in results when different flow cytometers are utilized to analyze the same sample. Fluorochrome-dependent instrument sensitivity also has been reported by numerous investigators. As more and more procedures are performed by cytometric analysis, light scatter and fluorescence limitations, which appear to be instrument dependent, demonstrate that not all flow cytometers have the same capabilities. Attempts were made to calculate molecules of equivalent soluble fluorochrome (MESF) values on nine different flow cytometers using fluorescein isothiocyanate (FITC) and R-phycoerythrin (R-PE) labeled microsphere reference standards produced by Flow Cytometry Standards Corporation (FCSC). Dramatic differences were observed in the ability of some cytometers to resolve these microspheres. The diminished resolution appeared to be instrument model and fluorochrome dependent. We propose that diminished fluorescence resolution in certain flow cytometers could be responsible for significant variability in clinical values reported from laboratories utilizing different flow cytometers.
A connection admission control algorithm for self-similar traffic (2003)

This paper describes a CAC algorithm for self-similar traffic (SS-CAC), that can take into account multiplexing gains due to buffering, and multiplexing gains across independent sources. Several variations of this CAC are discussed, and the performance of SS-CAC against several standard theoretical algorithms is demonstrated using a number of numerical examples, varying mean and peak rates, the Hurst parameter, buffer sizes, and QoS objectives. It is shown that in general, no algorithm can be said to be consistently "optimistic" or "pessimistic", so it is important for the algorithm to take into account the characteristics of actual network traffic. A case is then made for measurement-based CACs, and a potential method by which the SS-CAC can be extended to incorporate performance and traffic measurements is discussed.
*MPEG VIDEO CODING: A basic tutorial introduction (1996)

Summary MPEG has been outstandingly successful in defining standards for video compression coding, serving a wide range of applications, bit-rates, qualities and services on a worldwide basis. The standards are based upon a flexible toolkit of techniques for bit-rate reduction. MPEG video coding uses a combination of motion-compensated interframe prediction (for reducingtemporal redundancy) with Discrete Cosine Transform (DCT) and variable length coding tools (for reducing spatial redundancy). The specification only defines the bitstream syntax and decoding process: the coding process is not specified and the performance of a coder will vary depending upon, for example, the quality of the motion-vector measurement, and the processes used for prediction-mode selection. * This Report is based on a European Broadcasting Union (EBU) Review item, from the ‘ Review, Winter 1995 (Ed. 266)’, and is published with permission. It was originally written by BBC R&D Manager, Dr. S.R. Ely and entitled: ‘ video ‐ A simple introduction’.