gebhart/patrepeval huggingface dataset:
Adenovirus Vector-Mediated <i>In Vivo</i> Gene Transfer of Brain-Derived Neurotrophic Factor (BDNF) Promotes Rubrospinal Axonal Regeneration and Functional Recovery after Complete Transection of the Adult Rat Spinal Cord (2004)

Neurotrophins have been shown to promote axonal regeneration, but the techniques available for delivering neurotrophins have limited effectiveness. The aim of this study was to evaluate the effect of adenovirus vector mediated gene transfer of brain-derived neurotrophic factor (BDNF) on axonal regeneration after spinal cord injury. We prepared adenovirus vectors encoding either beta-galactosidase (AxCALacZ) or BDNF (AxCABDNF). AxCALacZ was used to assess infection levels of the adenovirus BDNF produced by AxCABDNF was detected by Western blotting and its bioactivity was confirmed by bioassay. As a model of spinal cord injury, the rat spinal cord was completely transected at the T8 level. Immediately after transection, the vectors were injected into both stumps of the spinal cord. Axonal regeneration after transection was assessed by retrograde and anterograde tracing. In AxCALacZ-injected rats, adenovirus-infected cells were observed not only at the injected site but also in brainstem nuclei, as shown by LacZ expression. After the injection of the retrograde tracer fluorogold (FG) distal portion to the transection, AxCABDNF-injected rats showed FG-labeled neurons in the red nucleus. The anterograde tracer biotinylated dextran amine (BDA) injected into the red nucleus was also found in regenerating rubrospinal fibers distal to the transection. These tracing experiments demonstrated the regeneration of descending axons. In addition, rats of the AxCABDNF group showed significant locomotor recovery of hindlimb function, which was completely abolished by re-transection. These results indicate that the recovery was caused by regeneration of rubrospinal axons, not by simple enhancement of the central pattern generator.
Insights from the revelations of divine love and the contemplation to attain love (2004)

Religious conversion, following Bernard Lonergan, is deeply mystical: "other worldly falling in love," "total, [unconditional] and permanent self-surrender." Julian of Norwich and Ignatius of Loyola both give, albeit in quite different language, an experiential and imagination rich accounts of religious conversion. For Julian, this is the "oneing" of the soul to God; for Ignatius, the contemplation which makes "beings in love."
Rapamycin Prolongs Survival and Arrests Pathophysiologic Changes in Murine Systemic Lupus Erythematosus (1994)

Data from 3 independent experiments demonstrated that RAPA significantly reduced or prevented many pathologic features of lupus normally seen in the MRL/l mouse, and suggest that RAPA may be useful as a therapeutic agent in SLE in humans.
A foundation of CODD's relational maybe-operations (1983)

Database relations which possibly contain maybe-tuples and null values of type “value at present unknown” are studied. Maybe-tuples and null values are formally interpreted by our notion of representation , which uses classical notions of predicate logic, elaborates Codd's proposal of maybe-tuples, and adopts Reiter's concept of a closed world. Precise notions of information content and redundancy , associated with our notion of representation, are investigated. Extensions of the relational algebra to relations with maybe-tuples and null values are proposed. Our extensions are essentially Codd's, with some modifications. It is proved that these extensions have natural properties which are formally stated as being adequate and restricted . By the treatment of difference and division, our formal framework can be used even for operations that require “negative information.” Finally, extensions of update operations are discussed.
Cross-Nucleation between ROY Polymorphs (2005)

Cross-nucleation between polymorphs is a newly discovered phenomenon important for understanding and controlling crystal polymorphism. It contradicts Ostwald's law of stages and other theories of crystallization in polymorphic systems. We studied the phenomenon in the spontaneous and seeded melt crystallization of 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY), currently the most polymorphic system of known structures. We observed extensive and sometimes selective cross-nucleation between ROY polymorphs. Certain polymorphs could not nucleate without the aid of others. The new polymorph was found to be more or less thermodynamically stable than the initial one but to always grow faster than or as fast as the initial one. The temperature and surface characteristics of the seed crystals affected the occurrence of cross-nucleation. Our results show that the pathway of crystallization in polymorphic systems is not determined solely by the initial nucleation, but also by cross-nucleation between polymorphs and the different growth rates of polymorphs. This study identified a new metastable polymorph of ROY, the 10th of the family.
Defective hepatic lipoprotein receptor binding of beta-very low density lipoproteins from type III hyperlipoproteinemic patients. Importance of apolipoprotein E. (1984)

Apolipoprotein (apo-) E2 and beta-migrating very low density lipoproteins (beta-VLDL) (which were isolated from type III hyperlipoproteinemic subjects) both demonstrated defective binding to apo-E and apo-B,E receptors on dog liver membranes and to apo-B,E low density lipoproteins (LDL) receptors on fibroblasts. The defective binding activity of the apo-E2 and beta-VLDL varied from very poor to nearly normal. The ability of the beta-VLDL to interact with hepatic apo-E receptors was enhanced by the addition of normal apo-E3 to the beta-VLDL. Furthermore, cysteamine treatment of the apo-E2 in beta-VLDL enhanced binding of the beta-VLDL to both apo-E and apo-B,E receptors. The importance of apo-E in mediating the receptor binding of beta-VLDL to these receptors was confirmed by using monoclonal antibodies. The residual binding activity of beta-VLDL to apo-E and apo-B,E receptors was inhibited by greater than 90% with anti-apo-E, while the addition of anti-apo-B had little effect. The apo-B in the beta-VLDL was capable of binding to apo-B,E receptors after the hydrolysis of the beta-VLDL triglycerides with milk lipoprotein lipase. Lipase treatment yielded, two subfractions of beta-VLDL. One fraction (d = 1.02 to 1.03 g/ml) was enriched with apo-B100; the other fraction (d less than 1.006 g/ml) was enriched with apo-B48 and apo-E2. Significantly increased amounts of the apo-B100-enriched fraction bound to apo-B,E receptors. Inhibition of this binding caused by the addition of anti-apo-B indicated that the binding activity of this subfraction was mediated by apo-B100. The apo-B48-enriched fraction did not show a significant increase in receptor binding, suggesting that apo-B48 does not bind to these receptors. In a control experiment, it was shown that triglyceride-rich VLDL, which contain normal apo-E3 and apo-B100, bind significantly to both liver apo-E receptors and fibroblast apo-B,E receptors. This binding activity was inhibited by greater than 90% with anti-apo-E. Lipase hydrolysis of the VLDL did not further enhance their receptor-binding activity. These results demonstrate that apo-E, and not apo-B, is the major determinant mediating the receptor-binding activity of cholesterol-rich beta-VLDL and triglyceride-rich VLDL.
Cytoskeletal mechanics : models and measurements (2006)

This book presents a full spectrum of views on current approaches to modeling cell mechanics. The authors come from the biophysics, bioengineering and physical chemistry communities and each joins the discussion with a unique perspective on biological systems. Consequently, the approaches range from finite element methods commonly used in continuum mechanics to models of the cytoskeleton as a cross-linked polymer network to models of glassy materials and gels. Studies reflect both the static, instantaneous nature of the structure, as well as its dynamic nature due to polymerization and the full array of biological processes. While it is unlikely that a single unifying approach will evolve from this diversity, it is the hope that a better appreciation of the various perspectives will lead to a highly coordinated approach to exploring the essential problems and better discussions among investigators with differing views
Vibration Analysis of Eight-wheel Lunar Rover with the Torsion-bar and Rocker Structure (2007)

Vibration analysis is an important route for improving the driving smoothness and stability of lunar rover. The structure characteristic of the eight-wheel lunar rover with tension-bar and rocker structure is that the ground flatness inputs of each two wheels hinged by the same rocker are intercoupling. The ground flatness excitation is equivalently transformed, which is the main excitation source, then the equivalent ground flatness function is obtained and, the vibration model and differential equation of the vibration system of the 7 DOF lunar rover are established. The differential equation of the vibration system is solved by Gaussian elimination and Runge-Kutta numerical method after Fourier transformation. The amplitude-frequency characteristic curve of the bodywork center of mass, the amplitude-frequency characteristic curve of vibration acceleration, and the relation curve between damps and the root mean square of the suspension flexibility were got by programming by means of Matlab. The driving smoothness and stability of the lunar rover is analyzed. The factors in the driving smoothness and stability are pointed out. And the variation range of damps for improving the driving smoothness and stability is presented.
The Concept of Energy Traceability: Application to EV Electricity Charging by Res (2015)

The energy sustainability, in the era of sources diversification [1], can be guaranteed by an energy resources utilization most correct, foreseeing no predominance of one source over the others in any area of the world but a proper energy mix, based on locally available resources and needs [2]-[4]. In this scenario, manageable with a smart grid system [5], [6], a virtuous use of RES must be visible, recognizable and quantifiable, in one word traceable [7]. The innovation of the traceability concept consists in the possibility of having information concerning the exact origin of the electricity used for a specific end use, in this case EV charging [8]. The traceability, in a context of increasingly sustainability [9], [10] and smartness city, is an important develop tool because only in this way it is possible to quantify the real emissions produced by EVs and to ensure the real foresight of grid load. This paper wants investigate the real ways to introduce this kind of real energy accounting, through the traceability.
A Novel Strategy for Three-Phase/Switch/Level (Vienna) Rectifier Under Severe Unbalanced Grids (2012)

Unbalanced grids introduce performance deterioration for Vienna rectifier topology by producing twice fundamental frequency ripples in dc-link voltage and input active/reactive power. A common current reference generation for the purpose of eliminating the input power ripple, such as dual-frame hybrid vector control, can maintain constant input power and eliminate ripples in dc-link voltage under light voltage unbalanced grids. Under severe unbalanced grids, this type of a control method will fail to work. This paper first analyzes the theoretical operation area of a constant power control method under unbalanced grids, and then a novel control method is proposed. The proposed control method can work under severe unbalanced grids by injecting a small amount of input power ripple and balance the performance of working area and output dc voltage ripples. Finally, the experiment results using the constant power control method are given and validate the performance of the proposed control method.
Adaptive Smart Control Method for Electric Vehicle Wireless Charging System (2018)

In order to shorten the wireless charging time of electric vehicles (EVs) and achieve stable charging, an adaptive smart control method for EV wireless charging is proposed in the paper. The method dynamically tracks the rechargeable battery state during the whole charging process, realizes multi-stage charging of constant current (CC) or constant voltage (CV) by switching two kinds of compensation networks of bilateral L3C and L3C-C, and regulates the charging voltage and current to make it as close as possible to the battery charging characteristic curve. This method can be implemented because the voltage source connected to the coupler and the compensation networks of bilateral L3C and L3C-C have the CC and CV source characteristics, respectively. On the basis of the established adaptive smart control system of EV wireless charging, the experiments of wireless data transmission and adaptive smart charging were conducted. The results showed that the designed control system had a response time of less than 200 ms and strong anti-interference ability and it shortened the charging time by about 16% compared with the time using traditional charging methods, thereby achieving a fast, stable, safe, and complete wireless charging process.
Demand Response and Building Energy Simulation (2012)

Changes in electric usage by demand-side resources from their normal consumption patterns in response to changes in the price of electricity over time, or to incentive payments designed to induce lower electricity use at times of high wholesale market prices or when system reliability is jeopardized.
Nitric Oxide and Endothelial Dysfunction (2000)

In the past, the vascular endothelium was viewed largely as a passive, semipermeable barrier between blood and tissues for the exchange of substrates and products of metabolism. More recently, it has become clear that the endothelium plays an active role in the regulation of vascular homeostasis. A turning point in this altered perception of the endothelium occurred in 1980 with the seminal observation by Furchgott and Zawadzki that an intact endothelium is required for acetylcholine-induced vasodilation (1). Subsequent studies identified “endothelium-derived relaxing factor” (EDRF) as nitric oxide (NO·) (2,3). Since then, studies have shown that in addition to controlling vascular tone, endothelium-derived NO· (EDNO) also regulates platelet function, vascular growth and remodeling, and adhesion of inflammatory cells to the endothelial surface.
An adaptive 5G multiservice and multitenant radio access network architecture (2016)

Abstract This article provides an overview on objectives and first results of the Horizon 2020 project 5G NOvel Radio Multiservice adaptive network Architecture (5GNORMA). With 5G NORMA, leading players in the mobile ecosystem aim to underpin Europe's leadership position in 5G. The key objective of 5G NORMA is to develop a conceptually novel, adaptive and future‐proof 5G mobile network architecture. This architecture will allow for adapting the network to a wide range of service specific requirements, resulting in novel service‐aware and context‐aware end‐to‐end function chaining. The technical approach is based on an innovative concept of adaptive (de)composition and allocation of mobile network functions based on end‐user requirements and infrastructure capabilities. At the same time, cost savings and faster time to market are to be expected by joint deployment of logically separated multiservice and multitenant networks on common hardware and other physical resources making use of traffic multiplexing gains. In this context architectural enablers such as network function virtualization and software‐defined mobile networking will play a key role for introducing the needed flexible resource assignment to logical networks and specific virtual network functions. Copyright © 2016 John Wiley & Sons, Ltd.
Alzheimer disease: protein-protein interaction and oxidative stress. (1996)

Alzheimer disease, the most prevalent dementia of the aged, is defined by the concurrence of two filamentous brain lesions: neurofibrillary tangles and senile plaques. The lesions are temporally and spatially correlated to each other and to cognitive impairment suggesting that is a interaction between neurofibrillary tangles and senile plaques that might play a role in disease pathogenesis. Here we present findings demonstrating specific interactions between the major protein components of the lesions. Such an interaction is likely important to lesion genesis and to the overall cognitive deficits seen clinically. Also important are forces that stabilize and cement abnormal interactions and protect them form removal. Oxidative post-translational modifications is probably one of the major mediators that by disrupting cellular homeostatic balance both promotes abnormal interactions and makes them resistant to proteolytic removal. Overall, these findings support the view that the lesions of Alzheimer disease are intimately involved in neuronal destructions.
Rheological Studies of Microfibrillar Cellulose Water Dispersions (2010)

The rheological behaviour of microfibrillar cellulose (MFC) water dispersions has been investigated. For the first time a detailed study of shear dependent viscosity at low and high shear rate is presented. A peculiar time dependent behaviour measured in the area between 0 and 1000 s−1 was identified. The study shows a hysteresis loop in the shear rate–viscosity relationship at low shear rate. Additional time dependent shear rate measurements were performed, and a hypothesis for a mechanism of interaction and formation of a fibrils network was suggested. Higher temperature caused lower viscosity values, and this difference was increased at higher shear rate values. Oscillatory measurements showed how the closeness of the fibrils helps network creations. Data obtained from high shear measurements showed that 1% MFC water dispersions had a dilatant behaviour at ultra high shear rates with values increasing from 120 to 300 Pa s in the area between 180,000 and 330,000 s−1 .
Twinning in zeolite Y. The conversion of faujasite into a new zeolite structure (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwinning in zeolite Y. The conversion of faujasite into a new zeolite structureMarc Audier, John M. Thomas, Jacek Klinowski, David A. Jefferson, and Leslie A. BursillCite this: J. Phys. Chem. 1982, 86, 4, 581–584Publication Date (Print):February 1, 1982Publication History Published online1 May 2002Published inissue 1 February 1982https://pubs.acs.org/doi/10.1021/j100393a032https://doi.org/10.1021/j100393a032research-articleACS PublicationsRequest reuse permissionsArticle Views171Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications (2018)

Metal nanoparticles are extensively studied due to their unique chemical and physical properties, which differ from the properties of their respective bulk materials. Likewise, the properties of heterogeneous bimetallic structures are far more attractive than those of single-component nanoparticles. For example, the incorporation of a second metal into a nanoparticle structure influences and can potentially enhance the optical/plasmonic and magnetic properties of the material. This review focuses on the enhanced optical/plasmonic and magnetic properties offered by bimetallic nanoparticles and their corresponding impact on biological applications. In this review, we summarize the predominant structures of bimetallic nanoparticles, outline their synthesis methods, and highlight their use in biological applications, both diagnostic and therapeutic, which are dictated by their various optical/plasmonic and magnetic properties.
Electrostatic Aerosol Sampler for Light and Electron Microscopy (1967)

A two stage electrostatic aerosol sampler capable of accurate sampling of micron and submicron size aerosols onto any flat collecting surface of an area up to 5×10 cm2 is described. Size classification of the deposited aerosol is prevented by the use of a novel pulsed precipitating electric field. Sampling efficiency and the uniformity of the deposited aerosol has been determined using monodispersed flourescent aerosols over the size range from 0.028 to 3.2 μ. The sampler has been found to be very satisfactory for obtaining aerosol samples for electron or light microscopy.
Monophenolase Activity of Latent Banana Pulp Polyphenol Oxidase (1998)

The monophenolase activity of latent banana polyphenol oxidase (PPO) partially purified by using a combination of two aqueous two-phase systems based on Triton X-114 and PEG 8000 (Sojo et al. J. Agric. Food Chem. 1998, 46, 4924−4930) has been characterized in the presence of sodium dodecyl sulfate (SDS). The purification method used avoids the loss of monophenolase activity described for other banana pulp PPOs obtained by acetone powders. The activity presented a lag period before the steady-state rate was reached. The activity and lag period depended on the SDS, substrate, and enzyme concentration, the pH, and the presence of catalytic amounts of o-diphenol. The enzyme was characterized with an enzyme activation constant, Kact, of 2.4 μM. On the basis of these results we discuss why monophenolase activity is less studied (or detected) in plants based on the existence of two enzymatic forms, Eoxy and Emet, and the method used to purify the plant enzyme. Keywords: Polyphenol oxidase; monophenolase; monophenols; banana; tyramine; enzyme kinetics
Molecular and epidemiological study of human parechovirus infections in Taiwan (2016)

Background/Purpose: As routine diagnostic assays for human parechoviruses (HPeVs) have not been included in the enteroviruses surveillance network in Taiwan, HPeVs may be the actual pathogens of hundreds of untypeable enteroviruses-suspected isolates. Methods: In this study, these untypeable isolates collected from 2007 through 2012 were examined by reverse transcription-polymerase chain reaction (RT-PCR)-based methods to survey the epidemiology of HPeVs in Taiwan. Results: Thirty-eight HPeV isolates were identified from 575 untypeable isolates, including 23 HPeV type1 (HPeV1), 13 HPeV3, and two HPeV6. Most of the patients were Taiwanese children under 5 years of age and their infections were generally prevalent in summer and autumn, with the highest peak occurring in September. The ratio of male to female patients was 1.56 and 2.25 for HPeV1 and HPeV3, respectively. Fever and respiratory symptoms were reported in significantly more patients infected with HPeV1. The results of phylogenetic analyses showed that HPeV isolates between 2007 and 2012 belonged to different lineages, indicating that endemic circulation of HPeV existed in Taiwan. Conclusion: This study showed that HPeVs have been endemic in Taiwan for some years despite a low positive rate. The detection tests of HPeVs are needed to correct a diagnostic deficit in