gebhart/patrepeval huggingface dataset:
Autonomous control of care and welfare robot (2005)

In this paper, we propose a robot that can perform nursing tasks in a hospital or welfare facility. When a narrow environment such as that of a sickroom is assumed, the robot must be able to move about freely in arbitrary directions, and should be able to correctly position itself in relation to its target. The robot has omni-directional mechanism, and has high controllability and the capability to make small turns. White lines originally set up on the floor, such as those indicating a safe passage area or the centerlines in the building, were used as the reference point of the robot's guidance mechanism, and these lines are recognized using eight cameras. An optical wireless is used so as not to cause bad influence for the person who applied the heart pacer. As well, wireless correspondence between the robot and an operator enables the robot's autonomous movement in a hospital.
When Less Is More: Specific Capture and Analysis of Tumor Exosomes in Plasma Increases the Sensitivity of Liquid Biopsy for Comprehensive Detection of Multiple Androgen Receptor Phenotypes in Advanced Prostate Cancer Patients (2020)

We evaluated the advantages and the reliability of novel protocols for the enrichment of tumor extracellular vesicles (EVs), enabling a blood-based test for the noninvasive parallel profiling of multiple androgen receptor (<i>AR)</i> gene alterations. Three clinically relevant <i>AR</i> variants related to response/resistance to standard-of-care treatments (<i>AR</i>-V7 transcript, <i>AR</i> T878A point mutation and <i>AR</i> gene amplification) were evaluated by digital PCR in 15 samples from patients affected by Castration-Resistant Prostate Cancer (CRPC). Plasma was processed to obtain circulating RNA and DNA using protocols based on tumor EVs enrichment through immuno-affinity and peptide-affinity compared to generic extraction kits. Our results showed that immuno-affinity enrichment prior to RNA extraction clearly outperforms the generic isolation method in the detection of <i>AR</i>-V7, also allowing for a distinction between responder (R) and non-responder (NR) patients. The T878A mutation was detected, overall, in nine out of 15 samples and no approach alone was able to reveal mutations in all harboring samples, showing that the employed methods complement each other. <i>AR</i> amplification was detected in the majority of CRPC samples analysed using either cell-free DNA (cfDNA) or exosome isolation kits (80%). We demonstrated that selective isolation of a subset of circulating exosomes enriched for tumor origin, rather than analysis of total plasma exosomes, or total plasma nucleic acids, increases sensitivity and specificity for the detection of specific alterations.
User’s manual for the SF-12v2 health survey (2002)

This survey was conducted from March 1, 2014 to May 30, 2014. Gandek B, Bjorner BJ, Maruish EM (2002) User's Manual for the SF-12v2 Health Survey. Summary: The main objective of this manual is to document and explain each step in the scoring of SF-12v2 scales and summary measures using Norm-Based. Aim: To examine perceived stress and health-related quality of life (HRQOL) among Master User's Manual for the SF-12v2 Health Survey (With a Supplement.
Breast Thermography (1982)

This discussion of breast thermography reviews the following: techniques; the "normal" thermogram found in approximately 65% of gynecologic patients; analysis and classification of a thermogram; factors influencing thermograms (breast symmetry, breast size, age, parity, history of breast feeding, menstrual cycle, pregnancy and lactation, exogenous steroid therapy, menopause and danazol, family history of breast carcinoma, benign breast disease, and time; thermograms and breast carcinoma; and clinical considerations. The temperature and the vascularization of the breast, which are modified by endocrine, inflammatory, and tumoral influences, can be studied through pictures formed by multiple simultaneous temperature in measurements called thermograms. Thermographic examinations must be performed in a draft-free, temperature, and humidity controlled room, where a constant temperature 20 degrees C is maintained. Using telethermography, a front and right and left oblique views must be taken. For contact thermographic studies, the cholesterol plate or sheet on which color distribution corresponds the best to the patient's mean temperature should be selected and a front and an oblique view should be taken of each breast. Thermograms must be analyzed by noting anatomic and vascular symmetry, by measuring temperature differences between comparable areas of the 2 breasts, and by observing the normal round contour of the breast. In addition, repeat thermograms must be compared to previous studies and any observed change must be noted. Increased heat can be vascular, focal, or diffuse. Recent reports and opinions on relationships between abnormal thermograms and cancer are controversial. The most favorable reports on the value of thermograms in the identification and management of breast cancers originate from the University of Strasbourg and the Cancer Institute of Marseille. It is the belief of this physician that thermography is not a specific test for carcinoma detection, for the diagnosis of any other breast disease. It is, however, a sensitive marker of local thermal and vascular abnormalities, which can be helpful in focusing attention on specific patients and for research. The greatest interest of clinical thermography lies in its use in the detection of carcinoma. Patients who have an abnormal thermogram need thorough clinical evaluation. It is possible that the greatest potential application of thermography is in its use in comparison studies.
Aberrant Methylation Inactivates Somatostatin and Somatostatin Receptor Type 1 in Head and Neck Squamous Cell Carcinoma (2015)

The aim of this study was to define somatostatin (SST) and somatostatin receptor type 1 (SSTR1) methylation profiles for head and neck squamous cell carcinoma (HNSCC) tumors at diagnosis and follow up and to evaluate their prognostic significance and value as a biomarker.
Phenytoin Prodrug: Preclinical and Clinical Studies (1989)

The currently available phenytoin (PHT) solution has many disadvantages stemming from poor aqueous solubility of PHT. A novel approach to solve the problem has been the synthesis of a phosphate ester of PHT (PHT prodrug ACC-9653). This water-soluble compound is metabolized rapidly into PO4 and PHT. A four center open-label, baseline-controlled study of 43 patients with epilepsy maintained on oral twice-daily PHT monotherapy was performed to evaluate the safety and pharmacokinetic profile of the prodrug. Patients received an i.v. or i.m. dose of ACC-9653 at a dose equivalent to the patients' morning dose of PHT. Intravenous dosages were infused at a rate of 75 mg/min, and i.m. dosages were given as one or two injections. After a period of 6 days, during which patients were again maintained with oral PHT, they were given a dose of ACC-9653 via whichever route they had not yet received. The Tmax of the prodrug averaged 5.7 and 36 min (0.095 and 0.606 h) after i.v. and i.m. administrations, respectively. The elimination half-life of ACC-9653 (conversion from prodrug to PHT) after i.v. and i.m. administration was 8.4 and 32.7 min (0.140 and 0.545 h), respectively, and both were independent of the dose. The plasma clearance of ACC-9653 was not dependent on dose or route of administration and averaged 19.8 +/- 1.16 and 17.8 +/- 0.83 L/h after i.v. and i.m. administrations, respectively. The area under curve ratio of PHT after i.m. and i.v. ACC-9653 was 1.17 +/- 0.13 which was not significantly different from 1.(ABSTRACT TRUNCATED AT 250 WORDS)
Adipose Obese Gene Product, Leptin, Inhibits Bovine Ovarian Thecal Cell Steroidogenesis1 (1998)

Leptin, a recently-discovered hormonal product of the obese (ob) gene, circulates in the blood at levels paralleling those of fat reserves and regulates satiety. Although noninsulin-dependent diabetics are insulin-resistant and have greater levels of leptin than normal subjects, little evidence existed previously to support the notion that leptin can influence insulin action, particularly in the ovary. Therefore, we tested the hypothesis that leptin signals metabolic information to the reproductive system by directly affecting insulin-induced thecal cell function. Thecal cells from bovine ovarian follicles were cultured for 2 days in the presence of 10% fetal calf serum, and then cultured for an additional 2 days in serum-free medium with added hormones. Doses of 10 to 300 ng/ml of leptin increased (p < 0.05) insulin-induced proliferation of thecal cells by 8% to 16%. In contrast, leptin blocked (p < 0.05) insulin-induced progesterone and androstenedione production by thecal cells. Insulin and leptin had no effect (p > 0.10) on thecal cell viability. Specific high-affinity, low-capacity binding of 125I-leptin was also demonstrable in thecal cells. Furthermore, leptin did not compete for [125I]insulin binding to thecal cells, whereas unlabeled insulin did. In conclusion, leptin can directly attenuate insulin-induced steroidogenesis of thecal cells while stimulating proliferation of the same cell type. This inhibitory effect of leptin on steroidogenesis does not appear to be mediated through inhibiting binding of insulin to its receptor but rather appears to be mediated through leptin binding to its own receptor. These results provide evidence for a role of leptin as a metabolic signal to the reproductive system via direct action in the ovary.
Rab4 and Rab11 coordinately regulate the recycling of angiotensin II type I receptor as demonstrated by fluorescence resonance energy transfer microscopy (2008)

The recycling of G-protein-coupled receptors (GPCR) to the cell surface after internalization plays an important role in the regulation of overall GPCR activity. The angiotensin II type I receptor (AT1R) belongs to class B GPCRs that recycle slowly back to the cell surface. Previous studies have proposed that Rab11 controls the recycling of AT1R; however, recent reports show that Rab4, a rapid recycling regulator, co-localizes also with internalized AT1R. Different from the subcellular co-localization provided by fluorescence microscopy, fluorescence resonance energy transfer (FRET) microscopy provided the spatial relationship of AT1R with Rab4 and Rab11 in the nanometer-range proximity during the entire course of AT1R recycling. During the early recycling stage, internalized AT1Rs were mainly associated with Rab4 in the cytoplasm. During the mid-recycling stage, AT1Rs were associated with both Rab4 and Rab11 in the perinuclear compartments. However, during the late-recycling stage, AT1Rs were mainly associated with Rab11, both in the perinuclear compartments and the plasma membrane. Co-immunoprecipitation data confirmed these dynamic associations, which were disrupted by silencing of either the Rab4 or Rab11 gene. Based on these observations, we propose a Rab4 and Rab11 coordinated model for AT1R recycling.
CrumblR: Enabling proxemic services through opportunistic location sharing (2015)

The need for a device to determine its own location and share it with individual Location-Based Services (LBSs) prevents large-scale adoption of indoor services, specially those belonging to small businesses or those intrinsic to short-lived events. We present CrumblR - a proxemic service broker platform that advocates anonymised location sharing with place owners instead of LBS providers to receive value-added contextual services. By decoupling location detection from LBSs, CrumblR liberates users from disclosing their locations to individual service providers. Our platform relies on opportunistic sharing of wireless signal fingerprints with nearby places to enable discovery of proxemic services associated with the place. In this WiP paper, we present the architectural design and the simple place proximity detection algorithms used in CrumblR.
Tetcyclacis and triazole‐type plant growth retardants: Their influence on the biosynthesis of gibberellins and other metabolic processes (1987)

Abstract Reduction of shoot growth caused by the norbornanodiazetine derivative tetcyclacis and by the triazoles BAS 110¨ W, BAS 111¨ W and LAB 150 978 is probably due primarily to an inhibition of endogenous gibberellin (GA) formation. Treated plants are lower in biologically active GAs; reduction of shoot growth can be overcome by applying an appropriate dose of GA 3 ; in the fungi Gibberella fujikuroi and Sphaceloma manihoticola the formation of GAs is inhibited by these compounds; in a cell‐free system of pumpkin endosperm the reactions leading from entkaurene to ent‐kaurenoic acid are blocked by relatively low concentrations of the growth retardants. The oxidative steps from ent‐kaurene to ent‐kaurenoic acid are known to be dependent on cytochrome P‐450. A structural feature common to tetcyclacis and the triazole‐type compounds is an sp 2 ‐hybridised nitrogen atom located at the periphery of the molecule in a heterocycle. It appears likely that the lone electron‐pair on this atom interacts with the central iron atom of cytochrome P‐450 in the enzymes, resulting in inhibition. Previous work has shown that the activity of other enzymes containing cytochrome P‐450 is much less affected by these compounds than that of the ent‐kaurene oxidase. Therefore, it is concluded that distinct cytochrome P‐450 species occur in plants and that tetcyclacis, BAS 110 ¨ W, BAS 111 ¨ W and LAB 150 978 are efficient and specific inhibitors of GA biosynthesis at low concentrations. At higher concentrations and in special cases they may, however, also interfere with other metabolic reactions involving cytochrome P‐450.
Spun Prestressed Concrete Poles--Past, Present, and Future (1992)

Spun prestressed concrete poles offer many advantages in comparison to poles made from other materials. Due to the improved high strength concrete and steel materials coupled with the residual tensile strength inherent with prestressing, the poles are relatively elastic, corrosion resistant, attractive, maintennace-free, and long lasting products. The historical background to their use is reviewed. The spun pole offers an improved technology that combines the benefits of centrifugal casting with those of prestressing and high-strength concrete in the manufacturing process. Highlights of the manufacturing process are noted. The design and materials characteristics are also noted. New applications of concrete poles, and the economics of their use are pointed out.
Melting studies of short DNA hairpins: Influence of loop sequence and adjoining base pair identity on hairpin thermodynamic stability (1999)

Spectroscopic and calorimetric melting studies of 28 DNA hairpins were performed. These hairpins form by intramolecular folding of 16 base self-complementary DNA oligomer sequences. Sequence design dictated that the hairpin structures have a six base pair duplex linked by a four base loop and that the first five base pairs in the stem are the same in every molecule. Only loop sequence and identity of the duplex base pair closing the loop vary for the set of hairpins. For these DNA samples, melting studies were carried out to investigate effects of the variables on hairpin stability. Stability of the 28 oligomers was ascertained from their temperature-induced melting transitions in buffered 115 mM Na(+) solvent, monitored by ultraviolet absorbance and differential scanning calorimetry (DSC). Experiments revealed the melting temperatures of these molecules range from 32.4 to 60.5 degrees C and are concentration independent over strand concentrations of 0.5 to 260 microM; thus, as expected for hairpins, the melting transitions are apparently unimolecular. Model independent thermodynamic transition parameters, DeltaH(cal), DeltaS(cal), and DeltaG(cal), were determined from DSC measurements. Model dependent transition parameters, DeltaH(vH), DeltaS(vH), and DeltaG(vH) were estimated from a van't Hoff (two-state) analysis of optical melting transitions. Results of these studies reveal a significant sequence dependence to DNA hairpin stability. Thermodynamic parameters evaluated by either procedure reveal the transition enthalpy, DeltaH(cal) (DeltaH(vH)) can differ by as much as 20 kcal/mol depending on sequence. Similarly, values of the transition entropy DeltaS(cal) (DeltaS(vH)) can differ by as much as 60 cal/Kmol (eu) for different molecules. Differences in free energies DeltaG(cal) (DeltaG(vH)) are as large as 4 kcal/mol for hairpins with different sequences. Comparisons between the model independent calorimetric values and the thermodynamic parameters evaluated assuming a two-state model reveal that 10 of the 28 hairpins display non-two-state melting behavior. The database of sequence-dependent melting free energies obtained for the hairpins was employed to extract a set of n-n (nearest-neighbor) sequence dependent loop parameters that were able to reproduce the input data within error (with only two exceptions). Surprisingly, this suggests that the thermodynamic stability of the DNA hairpins can in large part be reasonably represented in terms of sums of appropriate nearest-neighbor loop sequence parameters.
Analysis of orbital decay time for the classical hydrogen atom interacting with circularly polarized electromagnetic radiation (2004)

Here we show that a wide range of states of phases and amplitudes exist for a circularly polarized (CP) plane wave to act on a classical hydrogen model to achieve infinite times of stability (i.e., no orbital decay due to radiation reaction effects). An analytic solution is first deduced to show this effect for circular orbits in the nonrelativistic approximation. We then use this analytic result to help provide insight into detailed simulation investigations of deviations from these idealistic conditions. By changing the phase of the CP wave, the time t(d) when orbital decay sets in can be made to vary enormously. The patterns of this behavior are examined here and analyzed in physical terms for the underlying but rather unintuitive reasons for these nonlinear effects. We speculate that most of these effects can be generalized to analogous elliptical orbital conditions with a specific infinite set of CP waves present. The paper ends by briefly considering multiple CP plane waves acting on the classical hydrogen atom in an initial circular orbital state, resulting in "jump-like" and "diffusion-like" orbital motions for this highly nonlinear system. These simple examples reveal the possibility of very rich and complex patterns that occur when a wide spectrum of radiation acts on this classical hydrogen system.
<title>Integration of design and manufacturing in a virtual enterprise using enterprise rules, intelligent agents, STEP, and work flow</title> (1997)

An enterprise's ability to deliver new products quickly and efficiently to market is critical for competitive success. While manufactureres recognize the need for speed and flexibility to compete in this market place, companies do not have the time or capital to move to new automation technologies. The National Industrial Information Infrastructure Protocols Consortium's Solutions for MES Adaptable Replicable Technology (NIIIP SMART) subgroup is developing an information infrastructure to enable the integration and interoperation among Manufacturing Execution Systems (MES) and Enterprise Information Systems within an enterprise or among enterprises. The goal of these developments is an adaptable, affordable, reconfigurable, integratable manufacturing system. Key innovative aspects of NIIIP SMART are: (1) Design of an industry standard object model that represents the diverse aspects of MES. (2) Design of a distributed object network to support real-time information sharing. (3) Product data exchange based on STEP and EXPRESS (ISO 10303). (4) Application of workflow and knowledge management technologies to enact manufacturing and business procedures and policy. (5) Application of intelligent agents to support emergent factories. This paper illustrates how these technologies have been incorporated into the NIIIP SMART system architecture to enable the integration and interoperation of existing tools and future MES applications in a 'plug and play' environment.
The distribution and expression profiles of human Aspartyl/Asparaginyl beta-hydroxylase in tumor cell lines and human tissues (2010)

Human aspartyl beta-hydroxylase (HAAH) is a highly conserved enzyme that hydroxylates epidermal growth factor-like domains in transformation-associated proteins. Previous studies showed that the HAAH gene was overexpressed in many human malignancies. The present study investigates the distribution and expression profiles of HAAH in a variety of tumor cell lines and human tissues. One hundred and four cases of carcinomas were retrieved from the pathology archives of Department of Pathology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University. Paraffin-embedded tissue specimens were immunostained with the HAAH monoclonal antibodies (MAb) generated to naked plasmid DNA containing N-terminal domain of the encoding HAAH gene and recombinant HAAH. Immunoreactivity was detected in 90.4% (94 positive cases) of carcinomas, including 88.5% of strong positive cases. In addition, HAAH mRNA levels were measured in seven tumor cell lines and in normal tissue. The results demonstrated that HAAH was highly expressed in the tumor cell lines in contrast to its low level of expression in normal tissue. The protein expression level of HAAH in the tumor cell lines by Western bolt analysis was comparable to the mRNA expression level. HAAH distribution in seven tumor cell lines was analyzed by immunofluorescence cell staining. The antigen was primarily localized in cytoplasm and plasmalemma. HAAH mAb exhibited high level binding to the four tumor cell lines (breast carcinoma MCF-7, hepatic carcinoma SMMC-7721, cervix cancer Hela and ovary cancer SKOV) and lower degrees of binding were observed with the other three (renal adenocarcinoma ACHN, bladder cancer BIU-87 and laryngeal cancer Hep-2). In contrast, normal mouse embryonic osteoblasts MC3T3 exhibited no staining. In conclusion, HAAH is overexpressed frequently a variety of carcinomas, indicating that overexpression of the enzyme correlates with the development and progression of carcinomas and it could serve as a prognostic biomarker to predict the clinical course of some carcinomas.
Zero-Shot Learning by Convex Combination of Semantic Embeddings (2013)

Several recent publications have proposed methods for mapping images into continuous semantic embedding spaces. In some cases the embedding space is trained jointly with the image transformation. In other cases the semantic embedding space is established by an independent natural language processing task, and then the image transformation into that space is learned in a second stage. Proponents of these image embedding systems have stressed their advantages over the traditional \nway{} classification framing of image understanding, particularly in terms of the promise for zero-shot learning -- the ability to correctly annotate images of previously unseen object categories. In this paper, we propose a simple method for constructing an image embedding system from any existing \nway{} image classifier and a semantic word embedding model, which contains the $\n$ class labels in its vocabulary. Our method maps images into the semantic embedding space via convex combination of the class label embedding vectors, and requires no additional training. We show that this simple and direct method confers many of the advantages associated with more complex image embedding schemes, and indeed outperforms state of the art methods on the ImageNet zero-shot learning task.