gebhart/patrepeval huggingface dataset:
Food-derived mutagens and carcinogens. (1992)

Cooked food contains a variety of mutagenic heterocyclic amines. All the mutagenic heterocyclic amines tested were carcinogenic in rodents when given in the diet at 0.01-0.08%. Most of them induced cancer in the liver and in other organs. It is noteworthy that the most abundant heterocyclic amine in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, produced colon and mammary carcinomas in rats and lymphomas in mice but no hepatomas in either. 2-Amino-3-methylimidazo[4,5-f]quinoline induced liver cancer in monkeys. Formation of adducts with guanine by heterocyclic amines is presumably involved in their carcinogenesis. Quantification of heterocyclic amines in cooked foods and in human urine indicated that humans are continuously exposed to low levels of them in the diet. These low levels of heterocyclic amines are probably insufficient to produce human cancers by themselves. However, a linear relationship between DNA adduct levels and a wide range of doses of a heterocyclic amine was demonstrated in animals. It suggests that even very low doses of heterocyclic amines form DNA adducts and may be implicated in the development of human cancer under conditions in which many other mutagens-carcinogens, tumor promoters, and factors stimulating cancer progression exist.
Sensor Selection for Aircraft Engine Performance Estimation and Gas Path Fault Diagnostics (2015)

This paper presents analytical techniques for aiding system designers in making aircraft engine health management sensor selection decisions. The presented techniques, which are based on linear estimation and probability theory, are tailored for gas turbine engine performance estimation and gas path fault diagnostics applications. They enable quantification of the performance estimation and diagnostic accuracy offered by different candidate sensor suites. For performance estimation, sensor selection metrics are presented for two types of estimators including a Kalman filter and a maximum a posteriori (MAP) estimator. For each type of performance estimator, sensor selection is based on minimizing the theoretical sum of squared estimation errors (SSEE) in health parameters representing performance deterioration in the major rotating modules of the engine. For gas path fault diagnostics, the sensor selection metric is set up to maximize correct classification rate (CCR) for a diagnostic strategy that performs fault classification by identifying the fault type that most closely matches the observed measurement signature in a weighted least squares sense. Results from the application of the sensor selection metrics to a linear engine model are presented and discussed. Given a baseline sensor suite and a candidate list of optional sensors, an exhaustive search is performed to determine the optimal sensor suites for performance estimation and fault diagnostics. For any given sensor suite, Monte Carlo simulation results are found to exhibit good agreement with theoretical predictions of estimation and diagnostic accuracies.
Abstract 293: Characterization of renal tumor-initiating cells in human renal carcinoma cell lines (2011)

Abstract High aldehyde dehydrogenase activity (ALDH) has been used as a putative marker for the tumor- initiating subpopulation in many cancer types. We previously showed that tumor-initiating cells in human osteosarcoma OS99-1 cell line can be identified using ALDH. In the current study we sought to determine whether ALDH can be also used as a marker to isolate tumor-initiating populations from human renal carcinoma cell lines. By using a xenograft model in which cells from human renal carcinoma cell line ACHN and Caki-2 were grown in NOD/SCID mice, we identified a subset of renal cells that were highly tumorigenic based on the high aldehyde dehydrogenase activity. Isolated cancer cells with relatively high aldehyde dehydrogenase activity (ALDHbr cells) revealed a greater colony-forming efficiency, higher proliferative output, the ability to grow in non-adhesive spheroids, the capability to undergo adipogenic and osteogenic differentiation, and increased expression of stem cell marker genes Oct3/4A, Nanog and Pax-2. In vivo experiments showed that ALDHbr cells were enriched with greater tumorigenicity compared to their counterparts with low ALDH activity (ALDHlo cells), generating new tumors with as few as 25 cells. The isolation of renal tumor-initiating cells by their high ALDH activity may lead to a new insight into the study of how renal cell carcinoma may take place, and may lead to effective prognostic and therapeutic strategies for the treatment of patients with kidney cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 293. doi:10.1158/1538-7445.AM2011-293
Management of <i>Meloidogyne hapla</i> on Lettuce in Organic Soil with Sudangrass as a Cover Crop (1998)

Host suitability for Meloidogyne hapla of six cover crops was tested in the greenhouse. Sudan-grass cv. Trudan 8 and rye (mixture of cultivars) were nonhosts; oat cv. Porter was a poor host; and phacelia cv. Angelia, oilseed radish cv. Renova, and yellow mustard cv. Martigena were maintenance hosts. When incorporated as a green manure before planting of lettuce cv. Mon-tello, sudangrass was the most effective of the cover crops in reducing egg production of M. hapla. Soil amendment with all parts of sudangrass resulted in lower reproduction of M. hapla on lettuce than soil amendment with only roots of sudangrass. Soil incorporation of 2-month-old (or younger) tissues of sudangrass was more effective in reducing nematode reproduction on subsequent lettuce plants than incorporation of 3-month-old tissues. Sudangrass was grown as a cover crop after lettuce for three growing seasons in field microplots and incorporated as a green manure before the first fall frost. Weight of lettuce heads was significantly higher and reproduction of M. hapla was significantly lower in sudangrass-amended microplots compared with those left fallow between lettuce crops, but results varied with year and nematode infestation level.
Effects of Potassium Buffers on Feed Intake in Lactating Dairy Cows and on Rumen Fermentation In Vivo and In Vitro (1986)

Twenty-four Holstein cows were used to compare acceptance of concentrates and complete rations containing 1) no buffer, 2) 1.8% potassium bicarbonate, 3) 1.2% potassium carbonate, or 4) 1.5% sodium bicarbonate in the concentrate. When concentrate and a forage blend were offered separately (comparison period 1), concentrate intake did not differ among treatments, but forage blend consumption and complete ration intake was greater with the potassium carbonate ration (comparison period 2). Rumen pH did not differ, but urine pH was higher in cows fed complete rations containing buffers. Cows fed potassium carbonate had higher milk fat percentages than cows fed sodium bicarbonate during the first comparison period and higher than controls during the second comparison period and produced more 3.5% fat-corrected milk and solids-corrected milk than cows fed sodium bicarbonate in both comparison periods. Milk protein percentage was lower in cows fed potassium carbonate diets as compared with those fed sodium bicarbonate diets, but total protein production was similar. In three continuous culture in vitro trials, potassium carbonate maintained fermenter pH comparably to sodium bicarbonate, and total volatile fatty acid and acetate production were similar.
Problems of determining true equilibrium pressures of hydrogen getters over a wide range of getter temperature and hydrogen sorption (1999)

We have assessed a conventionally configured apparatus to measure hydrogen equilibrium pressures of getter alloys over the temperature range of 25 to 400 °C and hydrogen concentration range of 0.02 to 1 H/A. An in situ approach has been proposed to correlate the measurements of different gauges using one of the precisely calibrated gauges as a standard reference. The pressure range of interest was 10−7–105 Pa and was covered using a Bayart–Alpert gauge, a spinning rotor gauge, and different capacitance gauges. The approach involves measuring the characteristic response of these instruments prior to determining hydrogen equilibrium pressures over the relevant range of wall and getter bed temperature. To evaluate the accuracy of the measurements, we performed an error propagation analysis. The use of a porous filter to avoid fines contamination and the adsorption/desorption kinetics of the walls of the system were both addressed.
Suppression of rat liver tumorigenesis by 25-hydroxycholesterol and all-trans retinoic acid: differentiation therapy for hepatocellular carcinoma. (1999)

To determine whether differentiation therapy is useful in treating patients with hepatoma, we assayed the effects of 25-hydroxycholesterol (25-OH) and/or all-trans retinoic acid (ATRA) on rat AH136B ascites hepatoma cells. Flow cytometric DNA analysis showed that treatment of cells with 25-OH alone induced entry into the sub-G1 phase in a dose-dependent manner. While ATRA alone was ineffective, it enhanced the activity of 25-OH. Condensed and fragmented nuclei occurred mainly in cells treated with 25-OH (4 microg/ml). When cells treated with 25-OH (4 microg/ml), or 25-OH (4 microg/ml) + ATRA (1 microM) were transplanted into Donryu rats, we found that tumor development was completely inhibited; in contrast, rats administered the methanol-treated AH136B cells developed tumors. These findings suggest that AH136B cells in the sub-G1 phase can not recover tumorigenicity, and that the administration of a 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, such as 25-OH, and ATRA may be effective in treating patients with hepatoma.
Scaling theory for double-gate SOI MOSFET's (1993)

A scaling theory for double-gate SOI MOSFETs, which gives guidance for device design (silicon thickness t/sub si/; gate oxide thickness t/sub ox/) that maintains a subthreshold factor for a given gate length is discussed. According to the theory, a device can be designed with a gate length of less than 0.1 mu m while maintaining the ideal subthreshold factor. This is verified numerically with a two-dimensional device simulator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Configuration relocation and defragmentation for run-time reconfigurable computing (2002)

Due to its potential to greatly accelerate a wide variety of applications, reconfigurable computing has become a subject of a great deal of research. By mapping the compute-intensive sections of an application to reconfigurable hardware, custom computing systems exhibit significant speedups over traditional microprocessors. However, this potential acceleration is limited by the requirement that the speedups provided must outweigh the considerable cost of reconfiguration. The ability to relocate and defragment configurations on field programmable gate arrays (FPGAs) can dramatically decrease the overall reconfiguration overhead incurred by the use of the reconfigurable hardware. We therefore present hardware solutions to provide relocation and defragmentation support with a negligible area increase over a generic partially reconfigurable FPGA, as well as software algorithms for controlling this hardware. This results in factors of 8 to 12 improvement in the configuration overheads displayed by traditional serially programmed FPGAs.
Crystal Structures of RIα Subunit of Cyclic Adenosine 5‘-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (<i>R</i><sub>p</sub>)-Adenosine 3‘,5‘-Cyclic Monophosphothioate and (<i>S</i><sub>p</sub>)-Adenosine 3‘,5‘-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP<sup>,</sup> (2004)

Cyclic adenosine 5'-monophosphate (cAMP) is an ancient signaling molecule, and in vertebrates, a primary target for cAMP is cAMP-dependent protein kinase (PKA). (R(p))-adenosine 3',5'-cyclic monophosphothioate ((R(p))-cAMPS) and its analogues are the only known competitive inhibitors and antagonists for cAMP activation of PKA, while (S(p))-adenosine 3',5'-cyclic monophosphothioate ((S(p))-cAMPS) functions as an agonist. The crystal structures of a Delta(1-91) deletion mutant of the RIalpha regulatory subunit of PKA bound to (R(p))-cAMPS and (S(p))-cAMPS were determined at 2.4 and 2.3 A resolution, respectively. While the structures are similar to each other and to the crystal structure of RIalpha bound to cAMP, differences in the dynamical properties of the protein when (R(p))-cAMPS is bound are apparent. The structures highlight the critical importance of the exocyclic oxygen's interaction with the invariant arginine in the phosphate binding cassette (PBC) and the importance of this interaction for the dynamical properties of the interactions that radiate out from the PBC. The conformations of the phosphate binding cassettes containing two invariant arginine residues (Arg209 on domain A, and Arg333 on domain B) are somewhat different due to the sulfur interacting with this arginine. Furthermore, the B-site ligand together with the entire domain B show significant differences in their overall dynamic properties in the crystal structure of Delta(1-91) RIalpha complexed with (R(p))-cAMPS phosphothioate analogue ((R(p))-RIalpha) compared to the cAMP- and (S(p))-cAMPS-bound type I and II regulatory subunits, based on the temperature factors. In all structures, two structural solvent molecules exist within the A-site ligand binding pocket; both mediate water-bridged interactions between the ligand and the protein. No structured waters are in the B-site pocket. Owing to the higher resolution data, the N-terminal segment (109-117) of the RIalpha subunit can also be traced. This strand forms an intermolecular antiparallel beta-sheet with the same strand in an adjacent molecule and implies that the RIalpha subunit can form a weak homodimer even in the absence of its dimerization domain.
ZntB Is a Novel Zn <sup>2+</sup> Transporter in <i>Salmonella enterica</i> Serovar Typhimurium (2002)

A Zn2+ transport system encoded by the zntB locus of Salmonella enterica serovar Typhimurium has been identified. The protein encoded by this locus is homologous to the CorA family of Mg2+ transport proteins and is widely distributed among the eubacteria. Mutations at zntB confer an increased sensitivity to the cytotoxic effects of Zn2+ and Cd2+, a phenotype that suggests that the encoded protein mediates the efflux of both cations. A direct analysis of transport activity identified a capacity for Zn2+ efflux. These data identify ZntB as a zinc efflux pathway in the enteric bacteria and assign a new function to the CorA family of cation transporters.
Dealing with publication bias in translational stroke research (2009)

Publication bias has been around for about 50 years. It has become a concern for almost 20 years in the medical research community. This review briefly summarizes the current status of publication bias, potential sources where bias may arise from, and its common evaluation methods. In the field of translational stroke research, publication bias has long been suspected; however, it has not been addressed with sufficient efforts. Its status has remained the same during the last decade. The author emphasizes the important role that publishers might play in addressing publication bias.
First application of a spherical‐aberration corrected transmission electron microscope in materials science (2002)

One of the most challenging tasks for high‐resolution electron microscopy is the investigation of the atomic structure of defects, interfaces, and grain boundaries. In particular, the application of thin films in electronic devices requires detailed knowledge of the microstructure, which can influence the electronic and optical properties. These tasks require a point resolution down to about 0.1 nm because this enables structure imaging for many semiconductors and metals. The resolution of transmission electron microscopes is limited, besides other parameters, by the spherical aberration coefficient Cs of the objective lens and the wavelength λ of the electrons. Commercial medium‐voltage microscopes up to 400 kV offer only a point resolution of 0.16 nm due to the high spherical‐aberration constant Cs of the electromagnetic objective lens. Controlling the value of Cs by a corrector lens system can offer the required resolution even at an acceleration voltage of 200 kV. Recently, a lens system for Cs‐correction, based on hexapole lenses, has been developed at the European Molecular Biology Laboratory in Heidelberg and incorporated in a commercial 200 kV instrument equipped with a field emission gun (Haider M, Rose H, Uhlemann H, Schwan E, Kabius B and Urban K Nature392: 768 (1998) [1]). This system allows the Cs‐value to be set between +2.0 mm and −0.05 mm. For the present investigation, we have adjusted a Cs‐value of 50 µm in order to achieve optimum phase contrast, which improved the point resolution to 0.14 nm. Structure imaging can be performed down to atomic distances of 0.14 nm. A further unique advantage of Cs correction is the reduction of contrast delocalization, which is a major obstacle in the interpretation of images of defects and interfaces. The influence of Cs on contrast delocalization is demonstrated for a Si/CoSi2 interface. The unique combination of a low acceleration voltage and aberration‐free imaging down to the information limit offers new prospects for the interpretation of non‐periodic structures as defects and interfaces in crystalline materials.
Wind-Climate Estimation Based on Mesoscale and Microscale Modeling: Statistical–Dynamical Downscaling for Wind Energy Applications (2014)

Abstract This paper demonstrates that a statistical–dynamical method can be used to accurately estimate the wind climate at a wind farm site. In particular, postprocessing of mesoscale model output allows an efficient calculation of the local wind climate required for wind resource estimation at a wind turbine site. The method is divided into two parts: 1) preprocessing, in which the configurations for the mesoscale model simulations are determined, and 2) postprocessing, in which the data from the mesoscale simulations are prepared for wind energy application. Results from idealized mesoscale modeling experiments for a challenging wind farm site in northern Spain are presented to support the preprocessing method. Comparisons of modeling results with measurements from the same wind farm site are presented to support the postprocessing method. The crucial element in postprocessing is the bridging of mesoscale modeling data to microscale modeling input data, via a so-called generalization method. With this method, very high-resolution wind resource mapping can be achieved.
Research on an improved amplitude modulation method of audio directional loudspeaker (2008)

Aimed at solving the harmonic distortion problem of the DSB (Double Side Band) method which is employed in audio directional loudspeaker, an improved amplitude modulation (AM) method is investigated. According to the parametric acoustic array principle and self-demodulation theory, the theoretical self-demodulation model of the improved AM method is established, and a conclusion that the variational phase in the improved AM method hardly affects the second pressure is drawn. Furthermore, the harmonic distortion of the improved AM method is analyzed theoretically and tested by experiments, and the results show that the improved AM method has a far smaller total harmonic distortion than the DSB method when their modulation factors are equal. However, the improved AM method can only be applied reasonably when the modulation factor is small, because its total harmonic distortion is notable when the modulation factor is high.
Análise sazonal do potencial antimicrobiano e teores de flavonoides e quinonas de extratos foliares de Aloe arborescens Mill., Xanthorrhoeaceae (2010)

Este trabalho teve como objetivos avaliar o potencial antimicrobiano e os teores de flavonoides e quinonas de extratos foliares de Aloe arborescens Mill., Xanthorrhoeaceae, produzidos em diferentes épocas do ano. Extratos etanólicos e clorofórmicos foram preparados a partir de folhas, os bioensaios de atividade antimicrobiana foram desenvolvidos pelo método de macrodiluição em caldo, e dosagens de flavonoides e quinonas foram realizadas nos extratos. Todos os extratos apresentaram ação inibitória sobre os microrganismos testados. O extrato clorofórmico de inverno apresentou a menor CIM (128 µg/mL) sobre B. subtilis. Os extratos clorofórmicos de inverno, primavera e verão apresentaram maior atividade antimicrobiana em relação ao extrato clorofórmico de outono. O extrato etanólico de inverno apresentou a menor CIM (256 µg/mL) e a menor CMM (512 µg/mL) sobre K. pneumoniae. Os extratos etanólicos de verão e outono mostraram baixa atividade antimicrobiana. Os teores de quinonas das folhas foram maiores nos períodos mais quentes de coleta (verão e outono), enquanto os teores de flavonoides foram semelhantes nos quatro períodos de coleta.
Palmoplantar Pustulosis: an Autoimmune Disease Precipitated by Smoking? (2002)

Ninety-five percent of patients with palmoplantar pustulosis are smokers at onset of the disease. The aim of this study was to determine whether these patients have serum antibodies to nicotinic acetylcholine receptors (nAChR ab) and if their sera induce a specific immunofluorescence in normal palmar skin. Sera from 45 patients with palmoplantar pustulosis and 23 patients with chronic hand eczema were analysed for muscle nAChR ab, and immunofluorescence was performed on healthy palmar skin. Forty-two percent of the patients with palmoplantar pustulosis but none of the eczema patients had raised levels of nAChR ab. Immunofluorescence showed staining on endothelial cells in the papillary dermis in 47% of all sera from patients with palmoplantar pustulosis and in those with nAChR ab in 68%. On palmar skin from smokers there was also a staining of the sweat duct. Sera from patients with chronic hand eczema were negative. Our findings indicate that palmoplantar pustulosis is an autoimmune disease, possibly induced by smoking.
Will children reveal their secret? The coronavirus dilemma (2020)

<b>Epidemiological evidence shows that SARS-CoV-2 infection in children is less frequent and severe than adults. Age-related ACE2 receptor expression, lymphocyte count and trained immunity might be the keystone to reveal children9s secret.</b>https://bit.ly/2QWpWxK
Strategic planning for disaster recovery with stochastic last mile distribution (2024)

This paper considers the single commodity allocation problem (SCAP) for disaster recovery, a fundamental problem faced by all populated areas. SCAPs are complex stochastic optimization problems that combine resource allocation, warehouse routing, and parallel fleet routing. Moreover, these problems must be solved under tight runtime constraints to be practical in real-world disaster situations. This paper formalizes the specification of SCAPs and introduces a novel multi-stage hybrid-optimization algorithm that utilizes the strengths of mixed integer programming, constraint programming, and large neighborhood search. The algorithm was validated on hurricane disaster scenarios generated by Los Alamos National Laboratory using state-of-the-art disaster simulation tools and is deployed to aid federal organizations in the US.