gebhart/patrepeval huggingface dataset:
Treatment of cardiac tumors by orthotopic cardiac transplantation. (1997)

Primary soft tissue tumors of the heart usually cannot be excised with adequate margins. Orthotopic heart transplantation (OHT) could allow complete resection of cardiac tumors and has been performed in selected patients. However, most are not transplanted because of the high risk of tumor recurrence or metastasis and the possible enhancement of tumor growth by immunosuppressive drugs. Six patients with soft tissue cardiac tumors have been transplanted at the Columbia Presbyterian Medical Center: one paraganglionoma and one fibroma (both benign), and four malignant primary sarcomas. In all cases, there was no preoperative evidence of metastasis. In all but one case, the tumor was completely resected with adequate margins at the time of transplantation. One sarcoma patient who had not received preoperative or postoperative chemotherapy died suddenly 2.6 months after operation with no evidence of tumor. One patient is alive at 38 months with diffuse metastatic disease; two patients were treated preoperatively with intensive doxorubicin-based chemotherapy (one of whom also received postoperative external-beam radiotherapy to a positive surgical margin) and are tumor free 16 and 6 months after transplantation. Our experience compares favorably with the worldwide results of OHT for cardiac tumors (an additional 13 patients).
Mosfet Modeling & BSIM3 User’s Guide (2002)

Circuit simulation is essential in integrated circuit design, and the accuracy of circuit simulation depends on the accuracy of the transistor model. BSIM3v3 (BSIM for Berkeley Short-channel IGFET Mod
Development of Novel Pharmacotherapeutics for Tobacco Dependence: Progress and Future Directions (2012)

Ongoing clinical assessment of potential smoking cessation agents offers the promise of new effective medications. Nevertheless, much of our current knowledge of molecular mechanisms of nicotine addiction derived from preclinical studies has not yet been leveraged for medications development.
Vertical-cavity surface-emitting laser diodes for short distance optical fiber networks (2002)

We have fabricated wavelength tunable vertical-cavity laser diodes in 2D arrays by molecular beam epitaxy, proton implantation, and wet chemical etching. Record low threshold currents of 650 /spl mu/A for continuous wave and 600 /spl mu/A for pulsed operation are obtained for devices with 8 /spl mu/m active diameter. Output power is up to 170 /spl mu/W CW and 400 /spl mu/W pulsed. The emission is single longitudinal and transversal mode at about 970 nm wavelength. Three terminals for each laser diode supply two separate currents for the independent control of output power and emission wavelength of individual elements in a 2D laser array. A record wide continuous wavelength tuning range of 8.2 nm is achieved in a slightly larger device with tuning currents of just 2.5 mA. Highly efficient and alignment tolerant coupling to single-mode optical fibers is demonstrated with quasi-planar vertical-cavity laser diodes which provide a two-sided light output. Direct contact butt coupling to flat cut single-mode optical fibers of 4.5 /spl mu/m diameter core results in coupling efficiencies over 90%. The lateral alignment tolerances defined by a -3 dB coupling efficiency decrease are as large as 5.6 /spl mu/m. Maximum power coupled into a 9 /spl mu/m diameter core fiber is 0.75 mW for a non-heat sinked laser diode.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Distinct Potassium Channel Polypeptide Encoded by the <i>Drosophila eag</i> Locus (1991)

Many of the signaling properties of neurons and other electrically excitable cells are determined by a diverse family of potassium channels. A number of genes that encode potassium channel polypeptides have been cloned from various organisms on the basis of their sequence similarity to the Drosophila Shaker (Sh) locus. As an alternative strategy, a molecular analysis of other Drosophila genes that were defined by mutations that perturb potassium channel function was undertaken. Sequence analysis of complementary DNA from the ether à go-go (eag) locus revealed that it encodes a structural component of potassium channels that is related to but is distinct from all identified potassium channel polypeptides.
Vacuolar status and water relations in embryonic axes of recalcitrant Aesculus hippocastanum seeds during stratification and early germination (2012)

Maintenance of high water content and desiccation sensitivity, as well as preservation of active vacuoles in embryonic axes after shedding, can be considered a specific feature of recalcitrant seeds, overlooked when studying tropical recalcitrants due to the short duration. The retained physiological activity of vacuoles allows them to function rapidly as dormancy is lost and when external conditions permit. Cell vacuolation precedes cell elongation in both hypocotyl and radicle, and provides impetus for rapid germination.
Semantics-aware Graph-based Recommender Systems Exploiting Linked Open Data (2016)

The ever increasing interest in semantic technologies and the availability of several open knowledge sources have fueled recent progress in the field of recommender systems. In this paper we feed recommender systems with features coming from the Linked Open Data (LOD) cloud - a huge amount of machine-readable knowledge encoded as RDF statements - with the aim of improving recommender systems effectiveness. In order to exploit the natural graph-based structure of RDF data, we study the impact of the knowledge coming from the LOD cloud on the overall performance of a graph-based recommendation algorithm. In more detail, we investigate whether the integration of LOD-based features improves the effectiveness of the algorithm and to what extent the choice of different feature selection techniques influences its performance in terms of accuracy and diversity. The experimental evaluation on two state of the art datasets shows a clear correlation between the feature selection technique and the ability of the algorithm to maximize a specific evaluation metric. Moreover, the graph-based algorithm leveraging LOD-based features is able to overcome several state of the art baselines, such as collaborative filtering and matrix factorization, thus confirming the effectiveness of the proposed approach.
An integrated cable equalizer circuit for 150 Mbit/s datatransmission (2002)

An integrated cable equalizer circuit for 150 Mbit/s data transmission is described. The DATA-signal comes from a 75 /spl Omega/ cable, which has nonconstant frequency dependent attenuation. For that reason the signal amplitude at the output of the equalizer is controlled with an Automatic Gain Control (AGC) loop. The circuit is implemented with a 1.2 /spl mu/m BiCMOS technology.
Tetramethylpyrazine as Potassium Channel Opener to Lower Calcium Influx into Cultured Aortic Smooth Muscle Cells (2003)

In the present study, the effect of tetramethylpyrazine (TMP) on calcium (Ca 2+) influx was investigated in cultured vascular smooth muscle (A7r5) cells using Fura-2 as an indicator. The increase of Ca 2+ concentration in A7r5 cells produced by vasopressin or phenylephrine was attenuated by TMP from 0.01 micromol/L to 1 mmol/L. The decrease in the intracellular potassium concentration in A7r5 cells by TMP from 0.01 micromol/L to 10 micromol/L was characterized using PBFI/AM. Inhibitors specific to the small conductance calcium-activated potassium (SKCa ) channel or the ATP-sensitive potassium (K ATP ) channel abolished the actions of TMP. The obtained results indicate that the decrease of Ca 2+ influx into A7r5 cells by TMP is mainly mediated by the opening of potassium channels.
Tetranitromethane. A Reagent for the Nitration of Tyrosyl Residues in Proteins<sup>*</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTetranitromethane. A Reagent for the Nitration of Tyrosyl Residues in Proteins*Mordechai Sokolovsky, James F. Riordan, and Bert L. ValleeCite this: Biochemistry 1966, 5, 11, 3582–3589Publication Date (Print):November 1, 1966Publication History Published online1 May 2002Published inissue 1 November 1966https://pubs.acs.org/doi/10.1021/bi00875a029https://doi.org/10.1021/bi00875a029research-articleACS PublicationsRequest reuse permissionsArticle Views721Altmetric-Citations483LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Evaluation of Urinary Protein Patterns in a Stone-Forming Animal Model using Two-Dimensional Polyacrylamide Gel Electrophoresis (1991)

The exact role of urinary proteins in kidney stone formation remains an area of controversy. Some investigators believe that urinary proteins are selectively incorporated within urinary calculi and as such have an active role in stone formation. Other investigators believe that urinary proteins are nonspecifically adsorbed into urinary crystals and thus have only a passive role in stone formation. In the current investigation a previously described stone-forming animal model (hyperoxaluric rat) was utilized along with an animal model for renal tubular injury (gentamicin nephrotoxicity) in an effort to clarify the role of urinary proteins in kidney stone formation. Urine specimens were collected before and after the induction of stone formation and after the induction of renal tubular injury. The purified proteins from each urine specimen were separated in two dimensions by electrophoresis resulting in a characteristic "map" of protein spots for each urine specimen. All animals in the stone-forming group had pathologic evidence of early stone formation (diffuse intranephronic calculosis). Early stone formation was consistently associated with a reduction in the excretion of low molecular weight urinary proteins (30,000 dalton and less than 20,000 dalton ranges). Alcian blue staining confirmed the presence of matrix within clumps of intranephronic calcium oxalate crystals. Renal tubular injury was associated with an increase in the excretion of low molecular weight proteins (approximate 20,000 dalton range) consistent with classical tubular proteinuria. These results suggest that low molecular weight urinary proteins are selectively incorporated within the crystalline structure of the stone early during its formation.
A Stat 1alpha Factor Regulates the Expression of the Human Vimentin Gene by IFN-gamma (2000)

Vimentin is an intermediate filament protein normally expressed in cells of mesenchymal origin. Here, we report an increase in vimentin gene transcription induced by the cytokine interferon-y (IFN-gamma). Northern blot analysis and reporter gene assays reveal that IFN-gamma induces vimentin gene transcription in HeLa cells. However, no increase in vimentin mRNA synthesis was observed de novo in MCF-7 cells, which do not already express vimentin. Band shift analysis shows that the Stat1alpha protein mediates vimentin induction by IFN-gamma. A human mutant fibroblast cell line (U3A), which lacks Stat1alpha but expresses vimentin mRNA, yields no increase in vimentin mRNA levels on the addition of IFN-gamma. These results suggest that the induction of vimentin gene expression might be an important part of a complex cellular response to IFN-gamma.
The Stronger Families in Australia (SFIA) Study: Phase 2 (2014)

This report presents a medium- to long-term evaluation of the Communities for Children (CfC) initiative. This Australian Government initiative aims to improve services for young children and their families and the communities they grow up in. The evaluation, known as the Stronger Families in Australia (SFIA) study, looks at the impact of CfC on child, family, and community outcomes. Phase 1 of the evaluation, published in 2009, found a small but positive impact of the initiative. This new report presents findings from Phase 2 of the study, which followed up 1,927 of the original study families, with the children now aged from 8-10 years old. Phase 2 also introduced a new cohort of 1,800 families and four new "contrast" sites.
Corrosion of aluminum and aluminum alloys (2000)

This volume presents comprehensive coverage of the corrosion behavior of aluminum and aluminum alloys, with emphasis on practical information about how to select and process these materials in order to prevent corrosion attack. Described are the characteristics of these materials and the influences of composition, mechanical working, heat treatment, joining methods, microstructure, and environmental variables on their corrosion.
Locally clocked pipelines and dynamic logic (2002)

Micropipelines and most of its variants use a delay-insensitive controller to moderate a pipeline. In search of improved performance, we depart from the delay-insensitive model in favor of a bounded-delay model for the controller. In particular, we demonstrate how a general delay-insensitive controller for level-sensitive pipelines can be improved by assuming a bounded-delay model and taking advantage of delay information to make the controller faster and more efficient. The new control scheme is referred to as locally clocked (LC) control. A highly pipelined logic technique called LC dynamic logic is presented that combines the bounded-delay controller for their comments and suggestions. with a latching dynamic logic gate design. Simulations comparing LC control with its delay-insensitive counterpart are presented. Also, an 8 /spl times/ 8 bit multiplier with a maximum frequency of 715 MHz for a 1 /spl mu/m CMOS process that uses LC dynamic logic is presented.
Compact High-Performance Multimode Interference Couplers in Silicon-on-Insulator (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We demonstrate compact multimode interference (MMI) couplers on silicon-on-insulator that exhibit both high performance and relaxed tolerances. The devices are fabricated with a single shallow etch step on 1.5-<formula formulatype="inline"> <tex Notation="TeX">$\mu$</tex></formula>m-thick silicon, and have a footprint of 12.8 <formula formulatype="inline"><tex Notation="TeX">$\mu$</tex></formula>m<formula formulatype="inline"><tex Notation="TeX">$\,\times\,$</tex></formula>456 <formula formulatype="inline"><tex Notation="TeX">$\mu$</tex></formula>m, including 100-<formula formulatype="inline"><tex Notation="TeX">$\mu$</tex></formula>m-long tapers at input and output. In a Mach–Zehnder configuration, we achieve an extinction ratio larger than 22 dB for transverse-electric polarization and larger than 20 dB for transverse-magnetic polarization. This extinction ratio is maintained in the full 1520- to 1580-nm band and for MMI width variations in a range of 0.45 <formula formulatype="inline"><tex Notation="TeX">$\mu$</tex> </formula>m. We also show appreciable tolerance differences between paired and general excitation MMIs. </para>
Methylene Green Electrodeposited on SWNTs-Based “Bucky” Papers for NADH and <scp>l</scp>-Malate Oxidation (2011)

This research introduces a cavity anode design based on new single-walled nanotube (SWNTs) papers, "bucky" papers, used for the oxidation (and regeneration) of nicotinamide adenine dinucleotide (NADH) and the oxidation of l-malate. The materials designed are paper-like processed composites containing also additives: BP11 sample contains SWNTs and isopropanol (IPA); the BPMG sample contains SWNTs, IPA, and methylene green (MG). NADH/NAD(+) is the cofactor responsible for the oxidation of l-malate by malate dehydrogenase (MDH), in the Krebs' cycle. Because of the high overpotential of NADH oxidation, poly methylene green (PMG) was utilized as the electrocatalyst to produce NAD(+). The electrocatalyst was deposited on the surface of the "bucky" papers by electropolymerization by means of 10 voltammetric cycles in a range of -0.5 V and +1.3 V (vs Ag/AgCl reference electrode) at a scan rate of 5 mV/s. The catalytic performance of PMG was evaluated by chronoamperometric measurements of NADH oxidation at 0.3 V in phosphate buffer and l-malate oxidation at 0.1 V in the presence of MDH. For both "bucky" papers, the chronoamperometric curves of PMG, current vs NADH concentration, show a linear relationship demonstrating to have a first order Fick's law behavior for concentrations of NADH lower than 6 mM. The chronoamperometric curves in the presence of MDH, current against l-malate concentration, show a Michaelis-Menten behavior where no inhibition or competitive reaction are detected. Additionally, the anodic materials were characterized by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS), the polymerization of MG is effectively observed in the form of particles nucleation. The anodes show an excellent electrocatalytic activity toward NADH oxidation. The electrode design is feasible, reproducible, and overall stable.
Improved Zero-Current-Switching PWM Boost Converter (2010)

An improved ZCS PWM Boost converter based on a zero-current-switching(ZCS) pulse width modulation(PWM) switching cell was proposed.The working principle of the improved ZCS PWM Boost converter and the soft scoitching realizing condition were detailly analyzed and simulated.The simulation results showed the improved ZCS PWM Boost converter was feasible and correct.
Cyclizations of Thioureas with a Hydroxy Group at the β-Position of the <i>N</i>-Substituent. I. Reaction with Cupric Acetate (1970)

Abstract The reaction of 1-(3-phenoxy-2-hydroxypropyl)-3-phenyl-2-thiourea (thiourea I) with cupric acetate was investigated. The desulfurization reaction by the cupric ion proceeded in refluxing ethanol to yield 2-anilino-5-phenoxymethyl-2-oxazoline. At room temperature, thiourea I and cupric acetate gave a copper complex and the oxazoline. When the complex was heated in ethanol, the same oxazoline and thiourea I were obtained, along with inorganic copper compounds. On the basis of an investigation of the structure of the complex and the decomposition of the complex, the reaction mechanism involving copper-complex formation was discussed. On the other hand, the reaction of 1-(3-phenoxypropyl)-3-phenyl-2-thiourea with cupric acetate under the same conditions gave 1-(3-phenoxypropyl)-3-phenyl-3-acetylurea.
Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome (AEDS): Association with clinical severity and phenotype (2014)

To date cytokines profile in AEDS is poorly described in children. We evaluated the interleukin (IL)-17, IL-23, and IL-10 levels in atopic eczema/dermatitis syndrome (AEDS) children and healthy controls, in atopic AEDS (aAEDS) and nonatopic (naAEDS) subtypes and their relationship with disease severity. A total of 181 children with aAEDS and 93 healthy children were evaluated. According to the skin-prick test (SPT) for allergens and serum total IgE, all patients were subdivided in two groups: 104 aAEDS and 77 naAEDS. In all patients, serum IL-17, IL-23, and IL-10 levels were detected. Serum IL-17 and IL-23 levels were significantly higher, and serum IL-10 levels were significantly lower in AEDS children than healthy group (p < 0.001). Moreover, serum IL-17 and IL-23 levels were significantly higher in aAEDS than in naAEDS subtypes (p < 0.001). Differently, serum IL-10 levels resulted similar in both subtypes. There was a correlation between Score Atopic Dermatitis (SCORAD) index and both IL-17 and IL-23 and an inverse correlation between SCORAD index and IL-10 in aAEDS and naAEDS types. Serum IL-17 and IL-23 values were positively related to total IgE levels (p < 0.0001) in aAEDS. Further increase of IL-17 and IL-23 levels was detected in aAEDS subjects with atopic diseases such as asthma and rhinitis than children with only allergic sensitization. Our study confirms the role of IL-17, IL-23, and IL-10 and their relationship with the severity of AEDS. We firstly found a correlation between high IL-17/IL-23 axis levels and different phenotypes of AEDS in children, suggesting its role as marker of "atopic march" and disease severity.
Establishment of a New Perchloric Acid Treatment Method to Allow Determination of the Total Endotoxin Content in Human Plasma by the Limulus Test and Clinical Application (1991)

We established a new method of plasma treatment for the removal of interfering factors in the plasma to allow detection of endotoxin by limulus test. The limulus test used was an endotoxin-specific chromogenic test, the Endospecy test. Perchloric acid (PCA) treatment and centrifugation (PCA method) is usually used to remove interfering factors from plasma, with the precipitate being discarded and the supernatant used to detect endotoxin. As the solubilized precipitates of endotoxin-spiked plasma and some patient plasma were found to contain the Endospecy activity, we have devised a new method assaying endotoxin in both the supernatant and precipitate. This study confirmed that the solubilized precipitate of endotoxin-spiked plasma had Endospecy activity and found that the precipitate had other endotoxin activities, such as lethality in galactosamine-sensitized mice and pyrogenicity in rabbits. We also confirmed that interfering factors were completely removed from plasma samples by this new method. The endotoxin level after the new PCA method was found to be about 8 times higher than that determined after PCA treatment and the new PCA method surpasses the conventional PCA method with regard to the positive rate of endotoxin contents in clinical samples. These results indicate that the new PCA method is superior to the PCA method as a plasma pretreatment method for limulus test.
RAM-based FPGA's: a test approach for the configurable logic (1998)

This paper proposes a methodology for testing the configurable logic of RAM-based FPGAs taking into account the configurability of such flexible devices. The methodology is illustrated using the XILINX 4000 family. On this example of FPGA, we obtain only 8 basic test configurations to fully test the whole matrix of CLBs. In the proposed test configurations, all the CLBs have exactly the same configuration forming a set of one-dimensional iterative arrays. The iterative arrays present a C-testability property in such a way that the number of test configurations 8 is fixed and independent of the FPGA size.
Nucleic acid squence database computer system (1982)

Nucleic Acid Sequence Database Demonstration Project of the National Biomedical Research Foundation was made available to interested users through telephone access to our computer (1,2). Over two hundred user groups requested access during the ten months of the demonstration. We are continuing the database as a computer "publication" on a subscription basis. Both magnetic tapes and direct "on line" access to our computer are provided. In this paper we describe the computer system that evolved over the first year of operation. In its development, we have benefitted from the questions and comments of the users and we have endeavored to attune the system to their interests and needs. We had been using the computer system ourselves for some time and had found that a computerized management system was essential to minimize the overall cost of collecting, updating, and critically reviewing the data. In preparing the information, we were the heaviest users of the system.