gebhart/patrepeval huggingface dataset:
Sol–gel-processed silica/polydimethylsiloxane/calcium xerogels as polymeric matrices for Metronidazole delivery system (2010)

Silica, silica/polydimethylsiloxane and silica/polydimethylsiloxane/calcium xerogels were examined as polymeric carriers for the controlled release of drug—Metronidazole. Characterization assays comprised analysis of the matrix by Fourier transform infrared spectroscopy (FTIR), determining the specific surface area of solids (BET) and scanning electron microscope (SEM) techniques and further monitoring in the ultraviolet and visible light regions (UV–Vis) of the in vitro release of the drug over time. Using tetramethoxysilane (TMOS) as a precursor of silica matrix and polydimethylsiloxane (PDMS) and calcium ions as additives, xerogels with different morphology and physical properties were obtained. The applied modifications diminished the porosity and hydrophilicity of the silica matrix as well as reduced the release of drug. Based on the presented results of this study, it may be stated that applied xerogel matrices, pure silica (SiO2) and modified silica (SiO2–CaO, SiO2–PDMS and SiO2–CaO–PDMS), could be promising candidates for the formulation in local delivery systems.
Biochemical markers of alcoholism (2007)

Alcohol and alcohol-related diseases have become a major cause of death in Western countries. The most sensitive and specific of the commonly used biomarkers of alcohol intake are carbohydrate-deficient transferrin (CDT), and the combination of gamma-glutamyltransferase (GGT) and CDT. Other widely used laboratory markers are GGT, mean corpuscular volume of erythrocytes and the ratio of aspartate aminotransferase to alanine aminotransferase. Blood ethanol levels reveal recent alcohol use. However, more specific and sensitive biomarkers to improve the detection of excessive alcohol use at an early stage are needed. New biomarkers, not yet used in routine clinical work, include phosphatidylethanol, fatty acid ethyl esters, ethyl glucuronide, sialic acid, and acetaldehyde adducts.
Neural computing on a one dimensional SIMD array (1989)

Parallel processors offer a very attractive mechanism for the implementation of large neural networks. Problems in the usage of parallel processing in neural computing involve the difficulty of handling the large amount of global communication between processing units and the storage of weights for each of the neural processor connections. This paper will discuss how massive parallelism in the form of a one dimensional SIMD array can handle indefinitely large networks in near real time by efficiently organizing the memory storage of weights, and input and output signals. Very little overhead time is used in communication of signals between processing units, and there is no idle time for any of the units. An advantage of SIMD array systems is that the arithmetic processing is done bit serially, with the result that trade-offs can be easily be made between the processor speed and precision of the signals and weights.
Quantitative multielement determination of metallic wear species in lubricating oils and hydraulic fluids (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative multielement determination of metallic wear species in lubricating oils and hydraulic fluidsRobert E. Kauffman, Costandy S. Saba, Wendell E. Rhine, and Kent J. EisentrautCite this: Anal. Chem. 1982, 54, 6, 975–979Publication Date (Print):May 1, 1982Publication History Published online1 May 2002Published inissue 1 May 1982https://pubs.acs.org/doi/10.1021/ac00243a031https://doi.org/10.1021/ac00243a031research-articleACS PublicationsRequest reuse permissionsArticle Views162Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fast transient response capacitor-free linear voltage regulator in 65nm CMOS (2011)

A fast transient response capacitor-free linear voltage regulator is presented. It provides an output voltage of 1.2V for supplying a digital signal processor with a load current of up to 200mA. The regulator incorporates both high static output voltage accuracy of better than 1 % for six sigma design and fast transient response. A load jump from 1mA to 150mA with a rise time of 100ns causes an undershoot of only 90mV. The voltage regulator is implemented in a 65nm CMOS process. Because no external capacitor is required the proposed regulator is well suited for System on Chip designs.
Radiation carcinogenesis: radioprotectors and photosensitizers (1982)

This paper outlines 1) some of the salient features of radiation carcinogenesis that are pertinent to the questions of how the carcinogenic effects might be influenced, 2) the effects of radioprotectors on ionizing radiation-induced cancer, and 3) the effect of photosensitizers on UVR-induced skin cancer.
Highly efficient SiC inverter for aircraft application with innova-tive thermal management (2019)

Power electronic systems for aircraft applications gain more and more interest due to increasing gravimetric power density on power stage level by utilizing advantages of WBG devices. However, the overall system design has to be optimized, including housing, mechatronic design and thermal management. This paper presents the power stage design of a highly efficient SiC drive inverter with fail-operational capabilities for a small electric aircraft utilizing only the laminar flow given by the air speed on the surface and thermal capacities of the inverter housing for cooling means.
The Effects of Filtering and Limiting on the Performance of QPSK, Offset QPSK, and MSK Systems (1980)

The effects on spectral densities, symbol waveshapes and P <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">e</inf> versus <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">S/N</tex> performances, resulting from the addition of filtering followed by hard limiting on raised cosine filtered QPSK, offset QPSK, and MSK point-to-point radio systems are studied. A mathematical model and physical insight are presented into the crosstalk phenomenon between quadrature channels, created in the systems by the effect of limiting on filtered signals. This crosstalk is shown to result whether the filtering is ideal or otherwise. Computergenerated and measured eye diagrams showing crosstalk as predicted on a filtered, then limited, offset QPSK signal are given. Measured and computed spectral density results are given which are in close agreement with each other, indicating that the computer model provides a good representation of the real system. In addition, an explanation of the shape of the power spectra associated with filtered, then limited, modulated signals is provided by studying the symbol waveshapes of these signals. Using the spectral density results and the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">P_{e} (S/N)</tex> performance findings, it is shown that for a microwave system which: 1) incorporates an amplitude limiting amplifying device in the transmitter, 2) must operate within the FCC limits for radiated spectrum, and 3) must operate at a spectral efficiency greater than 1 bit/s/Hz, offset QPSK modulation is the best choice of the three modulation methods studied.
The temporal specification technique for operating systems mechanisms (2003)

A technique is presented for specifying properties of concurrent programs at different levels of detail. The author models the concurrent execution of several programs by interleaved execution sequences of system states. These states can contain additional global information about programs being suspended, or about current processor allocation. Then the author uses linear, propositional temporal logic for characterizing the properties of such sequences. This enables him to specify the safety and liveness properties of concurrent programming constructs such as semaphores and communication commands of CSP. He applies the technique for specifying the functions implemented by the lowest layers of an operating system, such as processor sharing and input/output, and the low-level mechanisms used for implementing these functions, such as interrupts.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Evaluación de la contaminación del río San Juan entre el puente de la circunvalación y el puente giratorio (2010)

La contaminacion de las fuentes hidricas es una de las aristas de los problemas medio ambientales del mundo actual. Nuestro pais y en particular la ciudad de Matanzas, conocida internacionalmente como La Atenas de Cuba y La Ciudad de los Puentes no escapa de esta amenaza. Ciudad de poetas y puentes, se identifica por la belleza natural y en particular de su bahia y rios, por lo que mantener la identidad de la ciudad esta relacionado con mantener la identidad de sus recursos hidricos. El presente trabajo forma parte del estudio de la situacion medio ambiental del Rio San Juan, de gran interes social y recreativo, en el mismo se identifican las principales fuentes contaminantes en el tramo comprendido entre el Puente de la Circunvalacion y el Puente Giratorio, y se realiza un estudio de las caracteristicas fisicas, quimicas y biologicas de esta fuente hidrica objeto de estudio con el objetivo de evaluar la contaminacion de la misma.
The Application of the Chemical Array for Biological Study (2010)

The identification of specific interactions between small molecules and human proteins of interest is a fundamental step in chemical biology and drug development. The small molecules that bind to specific proteins can be used as tools to study the functions of proteins and biological processes in cells. We have developed an efficient method to obtain novel binding ligands of human proteins by a chemical array approach. Our method includes the use of cell lysates that express proteins of interest fused with red fluorescent protein (RFP) and high-throughput screening by merged display analysis, which removes false positive signals from array experiments. To demonstrate large-scale ligand screening for various human proteins of interest, the gene library GLORIA (Gene Library of Osada Laboratory at RIKEN for chemical array analysis) has been established. Using the systematic platform, we detected novel inhibitors of carbonic anhydrase II. We also have shown that this screening method is useful not merely for ligand screening of proteins of interest, but also for gaining insight into structure-affinity relationships (SARs) and for studies of "fragment-based approach."Traditional fragment-based ligand discoveries have been demonstrated by using several technologies, such as NMR spectroscopy and X-ray crystallography and mass spectrometry. We present initial studies of fragment-based approach to binding assay by using the chemical array format.
A platform for heterogeneous interconnection network management (1990)

A comprehensive network management function built into the interconnection network provides a means of meeting user needs of fault tolerance, performance, accounting, and security. However, meeting these needs on a heterogeneous interconnection network is several levels more complex than on a homogeneous network because of the existence of multiple protocol stacks for communication. An architecture that will solve this problem by analyzing the heterogeneous interconnection network as a single entity is proposed. The authors present the design issues evaluated in choosing this approach and establish the need for the various components in this architecture. An overview is presented of each of the components, and their place in the architecture is pointed out.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein (1999)

The N-terminus of human topoisomerase I participates in the binding of this enzyme to helicases and other proteins. Using the N-terminal 250 amino acids of human topoisomerase I and a yeast two-hybrid/ in vitro binding screen, a novel arginine-serine-rich peptide was identified as a human topoisomerase I-binding protein. The corresponding full-length protein, named topors, contains a consensus RING zinc finger domain and nuclear localization signals in addition to the arginine-serine-rich region. The RING finger domain of topors is homologous to a similar domain in a family of viral proteins that are involved in the regulation of viral transcription. When expressed in HeLa cells as a green fluorescent protein fusion, topors localizes in the nucleus in a punctate pattern and co-immunoprecipitates with topoisomerase I. These data suggest that topors is involved in trans-cription, possibly recruiting topoisomerase I to RNA polymerase II transcriptional complexes.
Cutaneous Involvement in Multiple Myeloma (2003)

In our series, there was a perfect correlation of immunoglobulin and light-chain type between the serum electrophoresis and the cutaneous plasma cells. Patients with MM showed a short survival once cutaneous metastases appeared independently of the therapy. The deletion the rb-1 gene may provide prognostically relevant information to identify a high-risk subset of patients with MM.
Casein Productionby Human Breast Cancer (1977)

SUMMARY Casein was measured in the sera of breast cancer pa tients, in breast cancer tumors, and in breast cancer cells in long-term tissue culture using a sensitive and specific ma dioimmunoassay. Levels present in breast cancer sera were not elevated above control values. Eight of forty-seven (17%) of the tumor samples tested were positive for casein, the highest level representing 0.003%ofthe soluble protein. When seven human breast cancer cell lines were assayed for casein, the results were uniformly negative even under conditions of stimulation by lactogenic hormones. In addi tion, direct immunoprecipitation of labeled cellular protein supported the negative result of the radioimmunoassay. Thus it appears that casein production is not a common characteristic of most human breast cancers.
A cone complementarity linearization algorithm for static output-feedback and related problems (1997)

This paper describes a linear matrix inequality (LMI)-based algorithm for the static and reduced-order output-feedback synthesis problems of nth-order linear time-invariant (LTI) systems with n/sub u/ (respectively, n/sub y/) independent inputs (respectively, outputs). The algorithm is based on a "cone complementarity" formulation of the problem and is guaranteed to produce a stabilizing controller of order m/spl les/n-max(n/sub u/,n/sub y/), matching a generic stabilizability result of Davison and Chatterjee (1971). Extensive numerical experiments indicate that the algorithm finds a controller with order less than or equal to that predicted by Kimura's generic stabilizability result (m/spl les/n-n/sub u/-n/sub y/+1). A similar algorithm can be applied to a variety of control problems, including robust control synthesis.
Nineteen-level Active Filter System using Asymmetrical Cascaded Converter with DC Voltages Control (2006)

This paper presents a shunt active power filter implementation based on asymmetrical cascaded multilevel converter. A drawback of using such converter in active filter applications is that it requires DC sources with two quadrants operation capability or system coupling through special transformers in order to avoid voltage-balancing problems. For the proposed control scheme no transformer is used and the DC voltages are individually controlled. Hence, no DC source is required to maintain the capacitors voltages constant. A start-up procedure is also discussed. Simulation and experimental results are provided to validate the proposed scheme
A combination of derepression of the lac operator-repressor system with positive induction by glucocorticoid and metal ions provides a high-level-inducible gene expression system based on the human metallothionein-IIA promoter. (1990)

We and others have introduced the use of the lac operator-repressor system as a method for providing inducible gene expression for gene transfer experiments in animal cells (M. C.-T. Hu, and N. Davidson, Cell 48:555-566, 1987; J. Figge, C. Wright, C. J. Collins, T. M. Roberts, and D. M. Livingston, Cell 52:713-722, 1988). To improve the dynamic range of such an inducible system, we have investigated the effects of combining the relief by isopropyl-beta-D-thiogalactoside (IPTG) of negative control by the lac system with positive induction by the natural inducers glucocorticoids and cadmium ion for a system based on the human metallothionein-IIA gene promoter. We used the chloramphenicol acetyltransferase gene as a reporter gene and inserted a lacO sequence into the promoter between the GC box and metal-responsive element 1, between metal-responsive element 1 and the TATA box, or between the TATA box and the transcription start site. Surprisingly, all of these insertions had a significant inhibitory effect on promoter activity even in the absence of repressor. However, with these lacO-containing constructs, the levels of gene expression after induction by glucocorticoid, Cd2+, or both were considerably reduced in cells engineered to express the lac repressor. Derepression by IPTG, coupled with induction by both dexamethasone and Cd2+ ion, then provided a high level of induced expression, i.e., by a factor of approximately 100 over the basal level of expression. However, inserting the lacO sequence well upstream just before the glucocorticoid-responsive element had much smaller effects on expression levels in both repressor-negative and repressor-positive cells. This study describes a new, high-level-inducible promoter system for gene transfer experiments. The observed effects are discussed in terms of current models of the mechanisms by which transcription factors control gene expression.
Human serum albumin nanoparticles modified with apolipoprotein A-I cross the blood-brain barrier and enter the rodent brain (2010)

Nanoparticles made of human serum albumin (HSA) and modified with apolipoproteins have previously been shown to transport drugs, which normally do not enter the brain, across the blood-brain barrier (BBB). However the precise mechanism by which nanoparticles with different apolipoproteins on their surface can target to the brain, as yet, has not been totally elucidated. In the present study, HSA nanoparticles with covalently bound apolipoprotein A-I (Apo A-I) as a targetor for brain capillary endothelial cells were injected intravenously into SV 129 mice and Wistar rats. The rodents were sacrificed after 15 or 30 min, and their brains were examined by transmission electron microscopy. Apo A-I nanoparticles could be found inside the endothelial cells of brain capillaries as well as within parenchymal brain tissue of both, mice and rats, whereas control particles without Apo A-I on their surface did not cross the BBB during our experiments. The maintenance of tight junction integrity and barrier function during treatment with nanoparticles was demonstrated by perfusion with a fixative containing lanthanum nitrate as an electron dense marker for the permeability of tight junctions.
Diffusion Charging-Based Aerosol Instrumentation: Design, Response Characterisation and Performance (2018)

The growing concern for the air quality in urban areas and the subsequent development of measurement networks has increased the need for lightweight and cost-effective air quality instrumentation. In urban areas, traffic-related emissions are one of the major contributors to the worsened air quality, which in turn has led to the stringed emission regulations set for vehicles. These regulations necessitate both on-board monitoring of the operation of the exhaust after-treatment devices and measurement of the real-word driving emissions with portable emission measurement systems. Both of these aspects increase the demand for sensor-type instrumentation for emission measurement.<br/><br/>This thesis focusses on the development of diffusion charging–based aerosol instrumentation towards more compact and sensor-type instruments. The work was started by developing an add-on module for the electrical low-pressure impactor. This extended the instrument measurement capabilities by enabling the measurement of the effective density of particles in real-time. Focussing more on the sensor-type instrumentation, three different sensors were presented for measuring particle emission directly from the exhaust line: Two of them targeting the engine laboratory work or for the portable emission measurement and one designed for on-board diagnostics. The instrument developed for the on-board emission measurement provided a very good temporal performance owing to the miniaturisation of the instrument design. Lastly, a new sensor design approach was presented in which the flow rate dependence of the instruments response is minimised. This, together with the minimised pressure drop in the design, helps in lowering the instrument cost by promoting the use of a low-cost fan for generating the sample flow.<br/><br/>Instrument response characterisation and response modelling made a central part of the study. Results from the characterisation measurements were presented for all instruments, and comprehensive response models were built for the sensor-type instruments. Depending on the instrument, both simplified approximations and theoretical responses of the instrument components were used as the starting point for the response models. Additionally, the instrument performance was demonstrated in practical measurements related to the application of each instrument. The obtained response models provide necessary information for the instrument performance evaluation and the measurement data processing.
Chemical structures of the core regions of <i>Campylobacter jejuni</i> serotypes O:1, O:4, O:23, and O:36 lipopolysaccharides (1993)

Complete structures, including the location of N-acetylneuraminic acid (Neu5Ac) residues, were assigned for the core regions of Campylobacter jejuni serotypes O:1, O:4, and O:23 and O:36 lipopolysaccharides (LPS). In continuation of earlier studies, structure determinations of liberated oligosaccharides and, where necessary, of intact LPS, were by 1H-NMR spectroscopy, Smith degradation, chromium trioxide and enzymic degradations, in conjunction with methylation studies supported by fast-atom-bombardment mass spectrometry and linkage analyses by gas chromatography/mass spectrometry. It was concluded on the basis of the following structures, in which each was linked 1-->5 to a terminal 3-deoxy-D-manno-octulosonic acid residue, that the core regions with qualitatively similar sugar compositions showed serotypic differences in one or more of their sequences, linkage types, and anomeric configurations: [formula: see text] [corrected]. The outer regions of each structure carry Neu5Ac residues linked 2-->3 to available beta-D-Galp residues and show striking similarities with various glycosphingolipids of the ganglioside family. However, Neu5Ac epitopes are not apparently involved in determining serospecificity.