gebhart/patrepeval huggingface dataset:
Poly(4-hydroxy-<scp>l</scp>-proline ester):  Low-Temperature Polycondensation and Plasmid DNA Complexation (1999)

The cytotoxicity of a polycationic gene delivery system is critical for overall gene transfer efficency. Cells targeted for transfection must be able to support transcription and translation following gene delivery if treatment is to be successful. Cumulative cellular exposure time is one factor that mediates the cytotoxicity of polycations. Therefore, we hypothesized that hydrolytically degradable polycations, such as polyesters based on amino acids, could serve to reduce the cytotoxicity of polycationic gene delivery systems. In this paper, optimization of the low-temperature dicyclohexylcarbodiimide/(dimethylamino)pyridine (DCC/DMAP)-activated polycondensation of N-carbobenzyloxy-4-hydroxy-l-proline (CBZ-4-hydroxy-l-proline) to ultimately yield poly(4-hydroxy-l-proline ester) and the resulting polymer's interaction with plasmid DNA is reported. The optimized polycondensation of CBZ-4-hydroxy-l-proline resulted in a polymer with Mw = 7880. Deprotection of the CBZ group was afforded by palladium on activated carbon-catalyzed hydrogenolysis with little cleavage of the polyester backbone. The poly(4-hydroxy-l-proline ester) was able to electrostatically complex with plasmid DNA as determined by agarose gel retardation with complete retardation occurring at the DNA:polymer ratio of 1:1 (w:w). The poly(4-hydroxy-l-proline ester) also condensed plasmid DNA into nanostructures less than 150 nm at the DNA:polymer ratio 1:3 (w:w). The in vitro cytotoxicity of the polymer was compared to that of polylysine and polyethylenimine. The minimum viability of cells incubated with poly(4-hydroxy-l-proline ester) was 85%, which is excellent when compared to the cases of polylysine (20%) and polyethylenimine (2%).
A comparison of convolutional and Walsh coding in OFDM wireless LAN systems (2002)

A Walsh coded OFDM system is described which could provide an alternative to convolutional coding in packet based wireless LAN systems. This allows lower complexity decoding and lower peak-to-average power ratios. This system is compared with a hard decision decoded convolutional receiver, based on the OFDM specifications for the IEEE 802.11 and ETSI HIPERLAN/2 physical layer standards. In multipath environments, the high diversity Walsh coded OFDM system shows large improvements over uncoded systems and similar performance to the more computationally complex convolutional receivers.
<i>HapticFlow</i>: PDE‐based mesh editing with haptics (2004)

Abstract This paper presents HapticFlow , a haptics‐based direct mesh editing system founded upon the concept of PDE‐based geometric surface flow. The proposed flow‐based approach for direct geometric manipulation offers a unified design paradigm that can seamlessly integrate implicit, distance‐field based shape modeling with dynamic, physics‐based shape design. HapticFlow provides an intuitive haptic interface and allows users to directly manipulate 3D polygonal objects with ease. To demonstrate the effectiveness of our new approach, we developed a variety of haptics‐based mesh editing operations such as embossing, engraving, sketching as well as force‐based shape manipulation operations. Copyright © 2004 John Wiley & Sons, Ltd.
Flat transformation optics graded-index (TO-GRIN) lenses (2012)

This paper illustrates the use of quasi-conformal (QC) transformation optics (TO) techniques to design flat gradient-index (GRIN) lenses as replacements for conventional optical lenses. Three flat TO lenses are considered to demonstrate the flexibility of the new design approach. Two dimensional (2D) Finite-Difference Time Domain (FDTD) simulations show equivalent performance between the original lenses and the flat TO lenses. Furthermore, a body of revolution (BOR) FDTD method was developed and employed to characterize the imaging properties of the three dimensional (3D) cylindrical lenses, validating the predictions of 2D simulations. These designs only require spatially-varying dielectric materials with no magnetic properties, facilitating low-loss, broadband operation in both the microwave and optical regimes.
Laser Damage Resistant Polysiloxane Polymers as Homeotropic Alignment Layers for Liquid Crystal Devices (1986)

ABSTRACTWe report the discovery of a class of commercially available polysiloxane resins which can be used to produce homeotropic aligning layers of high optical quality and laser damage resistance for liquid crystal devices. Uniform films of interferometric quality can be easily and reproducibly applied by conventional spin-coating techniques and thermally cured to produce coatings which generate good homeotropic alignment with cyanobiphenyls at cell spacings as large as 167 microns.
Construction of an Efficient Biologically Contained <i>Pseudomonas putida</i> Strain and Its Survival in Outdoor Assays (1998)

Active biological containment systems consist of two components, a killing element designed to induce cell death and a control element which modulates the expression of the killing function. We constructed a mini-Tn5 transposon bearing a fusion of the Plac promoter to the gef killing gene and a fusion of the Pm promoter to the lacI gene plus the positive regulator of the Pm promoter, the xylS gene. This mini-Tn5 transposon was transferred to the chromosome of Pseudomonas putida CMC4, and in culture this strain survived in the presence of 3-methylbenzoate (an XylS effector) and committed suicide in the absence of this aromatic compound. The rate of killing escape was on the order of 10(-8) per cell and per generation. This contained strain and an uncontained control strain were used in outdoor tests performed in the spring-summer and autumn-winter periods to determine their survival in planted and unplanted soils with and without 3-methylbenzoate. In unplanted soils the numbers of both the contained strain and the uncontained strain per gram of soil tended to decrease, but the numbers of the contained strain decreased faster in soils without 3-methylbenzoate. The decrease in the number of CFU per gram of soil was faster in the spring-summer period than in the autumn-winter period. In planted soils survival in the rhizosphere and survival in bulk soil were studied. In the rhizosphere the uncontained control strain tended to become established at levels on the order of 10(5) to 10(6) CFU/g of soil regardless of the presence of 3-methylbenzoate. In the bulk soil the numbers of bacterial cells were 2 to 3 orders of magnitude lower. In planted soils the contained strain tended to disappear, but this tendency was more pronounced in the absence of 3-methylbenzoate and occurred faster in the summer assay than in the winter assay. We found no evidence of dispersal of the test strains outside the experimental plots.
Current Challenges and Opportunities in Treating Glioblastoma (2018)

Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, has a high mortality rate despite extensive efforts to develop new treatments. GBM exhibits both intra- and intertumor heterogeneity, lending to resistance and eventual tumor recurrence. Large-scale genomic and proteomic analysis of GBM tumors has uncovered potential drug targets. Effective and "druggable" targets must be validated to embark on a robust medicinal chemistry campaign culminating in the discovery of clinical candidates. Here, we review recent developments in GBM drug discovery and delivery. To identify GBM drug targets, we performed extensive bioinformatics analysis using data from The Cancer Genome Atlas project. We discovered 20 genes, <i>BOC</i>, <i>CLEC4GP1</i>, <i>ELOVL6</i>, <i>EREG</i>, <i>ESR2</i>, <i>FDCSP</i>, <i>FURIN</i>, <i>FUT8-AS1</i>, <i>GZMB</i>, <i>IRX3</i>, <i>LITAF</i>, <i>NDEL1</i>, <i>NKX3-1</i>, <i>PODNL1</i>, <i>PTPRN</i>, <i>QSOX1</i>, <i>SEMA4F</i>, <i>TH</i>, <i>VEGFC</i>, and <i>C20orf166AS1</i> that are overexpressed in a subpopulation of GBM patients and correlate with poor survival outcomes. Importantly, nine of these genes exhibit higher expression in GBM versus low-grade glioma and may be involved in disease progression. In this review, we discuss these proteins in the context of GBM disease progression. We also conducted computational multi-parameter optimization to assess the blood-brain barrier (BBB) permeability of small molecules in clinical trials for GBM treatment. Drug delivery in the context of GBM is particularly challenging because the BBB hinders small molecule transport. Therefore, we discuss novel drug delivery methods, including nanoparticles and prodrugs. Given the aggressive nature of GBM and the complexity of targeting the central nervous system, effective treatment options are a major unmet medical need. Identification and validation of biomarkers and drug targets associated with GBM disease progression present an exciting opportunity to improve treatment of this devastating disease.
Pleiotropic Signal Transduction Mediated by Human CD30: A Member of the Tumor Necrosis Factor Receptor (TNFR) Family (2002)

CD30, a member of the tumor necrosis factor receptor (TNFR) family, is a characteristic cell surface receptor for activated T-cells and the malignant cells of Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and a few other non-Hodgkin's lymphomas. As an independent predictor of disease progression and poor prognosis, high serum levels of soluble CD30 (sCD30) have prognostic significance for patients with CD30-positive lymphomas and viral infections. Activation of CD30 by ligand binding or cross-linking with immobilized antibody leads to trimerization of the receptor, recruitment of signaling proteins and transducing of numerous effects. Due to the lack of an intrinsic enzymatic domain, signal transduction is exclusively mediated by the members of the TNFR-associated factor (TRAF) family and the various TRAF-binding proteins. CD30 signaling can induce several pathways including the activation of NFkappaB and the MAP kinases. CD30 mediated signal transduction is capable of promoting cell proliferation and cell survival as well as antiproliferative effects and cell death depending on cell type and co-stimulatory effects. Some data indicate the opposite signaling of CD30 in HD or ALCL cells, while other information point to pleiotropic signaling pathways in both malignancies. The pro and contra of this controversy is discussed in this review.
An electric induction micromotor (2005)

This paper presents the analysis, design, fabrication, and testing of a planar electric induction micromotor. The micromotor is a 6-phase motor with 131 pole pairs distributed on a stator having a 4 mm outer diameter. The axial air gap is 3 /spl mu/m. With a 90 V stator excitation, applied at a 300-kHz slip frequency, the motor produces a torque of 2 /spl mu/N/spl middot/m. Special attention is paid to the limitations that microfabrication places on the design of the motor.
Primary Amines by Transfer Hydrogenative Reductive Amination of Ketones by Using Cyclometalated Ir<sup>III</sup> Catalysts (2013)

Cyclometalated iridium complexes are found to be versatile catalysts for the direct reductive amination (DRA) of carbonyls to give primary amines under transfer-hydrogenation conditions with ammonium formate as both the nitrogen and hydrogen source. These complexes are easy to synthesise and their ligands can be easily tuned. The activity and chemoselectivity of the catalyst towards primary amines is excellent, with a substrate to catalyst ratio (S/C) of 1000 being feasible. Both aromatic and aliphatic primary amines were obtained in high yields. Moreover, a first example of homogeneously catalysed transfer-hydrogenative DRA has been realised for β-keto ethers, leading to the corresponding β-amino ethers. In addition, non-natural α-amino acids could also be obtained in excellent yields with this method.
ROMP‐NMP‐ATRP combination for the preparation of 3‐miktoarm star terpolymer via click chemistry (2008)

Abstract A combination of ring opening metathesis polymerization (ROMP) and click chemistry approach is first time utilized in the preparation of 3‐miktoarm star terpolymer. The bromide end‐functionality of monotelechelic poly( N ‐butyl oxanorbornene imide) (PNBONI‐Br) is first transformed to azide and then reacted with polystyrene‐ b ‐poly(methyl methacrylate) copolymer with alkyne at the junction point (PS‐ b ‐PMMA‐alkyne) via click chemistry strategy, producing PS‐PMMA‐PNBONI 3‐miktoarm star terpolymer. PNBONI‐Br was prepared by ROMP of N ‐butyl oxanorbornene imide (NBONI) 1 in the presence of ( Z )‐but‐2‐ene‐1,4‐diyl bis(2‐bromopropanoate) 2 as terminating agent. PS‐ b ‐PMMA‐alkyne copolymer was prepared successively via nitroxide‐mediated radical polymerization (NMP) of St and atom transfer radical polymerization (ATRP) of MMA. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 497–504, 2009
Deepwater geohazard analysis using prestack inversion (2001)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2001Deepwater geohazard analysis using prestack inversionAuthors: Rob de KokNader DuttaMashuir KhanSubhashis MallickRob de KokWesternGeco, Nader DuttaWesternGeco, Mashuir KhanWesternGeco, and Subhashis MallickWesternGecohttps://doi.org/10.1190/1.1816697 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1816697FiguresReferencesRelatedDetailsCited byOn the inverse problem of reflection Green's function seismograms over stratified acoustic media: Estimation of background modelsLasse Amundsen30 September 2021 | GEOPHYSICS, Vol. 86, No. 6Quantitative Analysis of Geopressure for Geoscientists and Engineers10 February 2021 | , Vol. 74Geopressure prediction using seismic data: Current status and the road aheadN. C. Dutta11 November 2002 | GEOPHYSICS, Vol. 67, No. 6 SEG Technical Program Expanded Abstracts 2001ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2001 Pages: 2135 publication data© 2001 Copyright © 2001 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 03 Jan 2005 CITATION INFORMATION Rob de Kok, Nader Dutta, Mashuir Khan, and Subhashis Mallick, (2001), "Deepwater geohazard analysis using prestack inversion," SEG Technical Program Expanded Abstracts : 613-616. https://doi.org/10.1190/1.1816697 Plain-Language Summary PDF DownloadLoading ...
FMS job-shop scheduling under disruptions with consideration of time and sequence deviation (1999)

In this paper, we present a two-stage procedure off-line scheduling algorithm based on the Lagrangian relaxation method to maintain minimum mean weighted flow time for solving FMS job shop problems. On the other hand, uncertainties in the production environment inevitably result in deviations from the initial schedules. Five types of disruptions are considered in the case of rescheduling with an objective of maximum stability. Regarding the stability (time and sequence deviation) and efficiency (makespan), the simulation results of both short time and long time machine breakdown are illustrated for discussion.
OPINI APOTEKER DAN PASIEN TERHADAP PERAN APOTEKER DALAM PELAYANAN KEFARMASIAN DI APOTEK KOTA MERAUKE (2013)

Peran dan tanggung jawab apoteker terus berkembang dari tahun ke tahun, dari pengelolaan obat sebagai komoditi (drug oriented) menjadi pelayanan yang komprehensif yang berorientasi kepada pasien (patient oriented). Penelitian ini bertujuan untuk mengetahui bagaimana opini apoteker dan pasien dalam peran dan tanggung jawab tenaga kesehatan, dalam hal pelayanan yang telah dilakukan oleh apoteker di apotek, dan opini pasien mengenai ketrampilan apoteker dalam memberikan pelayanan kefarmasian. Pengambilan data dilakukan menggunakan kuesioner sebagai instrumen penelitian dengan responden apoteker dan pasien di apotek kota Merauke. Terdapat 142 responden yang terdiri dari 14 apoteker dan 128 pasien yang bersedia ikut serta dalam penelitian. Dari penelitian ini diperoleh hasil yaitu : 1) apoteker beropini bahwa pelayanan terkait obat merupakan peran dan tanggung jawab apoteker tetapi pasien cenderung menempatkan dokter dan apoteker, 2) apoteker merasa sudah melayani tetapi pasien belum merasakan, 3) pasien menilai apoteker trampil, tetapi masih kurang yakin dalam hal mengingatkan adanya pemeriksaan laboratorium.
Ride Comfort Optimization for Commercial Trucks (1990)

<div class="htmlview paragraph">The object of this study is to analyse the vehicle ride comfort problem called “FREEWAY HOP” for medium duty trucks.</div> <div class="htmlview paragraph">For appreciating of this phenomenon and its mechanism, vehicle modal testing and hydraulic shaker testing were conducted.</div> <div class="htmlview paragraph">And for checking the various effects of the tuning parameters, computer simulation and the parameter design methods, the well known “TAGUCHI METHOD” were used.</div> <div class="htmlview paragraph">Actual vehicle road testing under the new specifications was conducted to confirm the ride comfort performance.</div> <div class="htmlview paragraph">From these approach ride comfort optimization can be obtained.</div>
The structure of E. coli β-galactosidase (2005)

E. coli beta-galactosidase is a tetramer of four identical 1023-amino acid chains. Each chain consists of five domains, the third of which is an eight-stranded alpha/beta barrel that comprises much of the active site. This site does, however, include elements from other domains and other subunits. The N-terminal region of the polypeptide chains help form one of the subunit interfaces. Taken together these features provide a structural basis for the well-known property of alpha-complementation. Catalytic activity proceeds via the formation of a covalent galactosyl intermediate with Glu537, and includes 'shallow' and 'deep' modes of substrate binding.
Assessment of Regional Lung Function with Multivolume<sup>1</sup>H MR Imaging in Health and Obstructive Lung Disease: Comparison with<sup>3</sup>He MR Imaging (2014)

Findings in this study demonstrate that multivolume (1)H MR imaging, without contrast material, can be used as a biomarker for regional ventilation, both in healthy volunteers and patients with obstructive lung disease.
Modification of critical spin torque current induced by rf excitation (2008)

We characterize the spin transfer torque induced reversal for current-perpendicular-to-plane spin valves with in-plane magnetic anisotropy at low temperature when driven by both direct and rf currents. We find that for rf currents with frequencies in the range of the dc driven resonances, the rf current strongly influences the preswitching precessional modes leading to a clear dependence of the critical dc switching current on the external rf frequency excitation.
High Performance Context Adaptive Variable Length Coding Encoder for MPEG-4 AVC/H.264 Video Coding (2006)

This paper presents a high-performance VLSI architecture for context adaptive variable length coding (CAVLC) used in the MPEG-4 AVC/H.264 video coding. Instead of only the coarse-grained 8times8 zero block skipping in the previous design, the proposed design implements the fine-grained zero skipping at the 4times4 block level and the individual coefficient level. The implementation with 0.18mum CMOS process just needs average 6.88 cycles for one block coding and costs 11.9K gates when working at 100 MHz. This design saves more than half of cycle count and 48% of area cost when compared with the other designs
Serial immunocytologic analysis of blood for tumor cells in two patients with neuroblastoma (1991)

Tumor surveillance tests are used to determine whether malignant cells are responsive or resistant to therapeutic regimens. For patients with neuroblastoma, conventional methods of surveillance are not sensitive enough. Because tumor cells are shed into the circulation, immunocytologic analysis of blood may function as a sensitive monitoring system. In this study, five blood samples were obtained from two patients with disseminated neuroblastoma at diagnosis and during therapy. These samples were analyzed with monoclonal antibodies and immunoperoxidase staining to determine whether circulating neuroblasts were present. In both patients, the presence or absence of circulating neuroblasts yielded information that was more sensitive than that from conventional tests. The authors conclude that immunocytologic analysis of blood should be included with conventional monitoring methods for surveillance of patients with disseminated neuroblastoma.
Zirconia membrane pH sensors (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTZirconia membrane pH sensorsLeonard W. Niedrach and William H. StoddardCite this: Ind. Eng. Chem. Prod. Res. Dev. 1983, 22, 4, 594–599Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/i300012a015https://doi.org/10.1021/i300012a015research-articleACS PublicationsRequest reuse permissionsArticle Views128Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts