gebhart/patrepeval huggingface dataset:
Analysis of Broadband Lamb-Wave Delay Lines (1986)

We present an equivalent circuit analy- sis method for Lamb-wave (LW) acoustic delay lines on piezoelectric ceramic plates. The transducer consists of a symmetric structure on the two plate surfaces in or- der to generate only the zeroth-order symmetric Lamb- wave. High efficiency and wideband unidirectionality are achieved by cutting a straight edge parallel to the fin- gers; placed in a distance of a fourth wavelength from the finger centre the edge behaves as a perfect acoustic re- flector. A minimum insertion loss of some 10 dB, caused by electrical mismatch, has to be accepted to keep the triple transit signal low. Our model for analysis is based on a modified Mason equivalent circuit combined with a P-matrix description in order to calculate reflections. Additionally, two detrimental effects, the electromag- netic coupling (crosstalk) between the input and output transducer caused by the high dielectric constant, and the bulk wave plate resonance, are taken into account. These are modelled by appropriate equivalent circuits. Furthermore, an extension of the aforementioned model is developed by calculating the charge distribution on the fingers. We compare the results of our model with measurements in the range between 0 and 4 MHz finding a fairly good agreement.
<i>SoxF</i>is part of a novel negative-feedback loop in the<i>wingless</i>pathway that controls proliferation in the<i>Drosophila</i>wing disc (2009)

Wnt molecules act as mitogenic signals during the development of multiple organs, and the aberrant activity of their pathway is often associated with cancer. Therefore, the production of Wnts and the activity of their signaling pathway must be tightly regulated. We have investigated the mechanisms of this regulation in the Drosophila hinge, a domain within the wing imaginal disc that depends on the fly Wnt1 ortholog wingless (wg) for its proliferation. Our results uncover a new feedback loop in the wg pathway in which the spatially restricted activation of the Sox gene SoxF (Sox15) by wg represses its own transcription, thus ensuring tight regulation of growth control. rotund, a wing proximodistal patterning gene, excludes SoxF from a thin rim of cells. These cells are thus allowed to express wg and act as the source of mitogenic signal. This novel mode of action of a Sox gene on the Wnt pathway -- through transcriptional repression of a Wnt gene -- might be relevant to human disease, as loss of human SoxF genes has been implicated in colon carcinoma.
Low resistivity indium–tin oxide transparent conductive films. I. Effect of introducing H2O gas or H2 gas during direct current magnetron sputtering (1990)

When an inline sputtering system is used to make conductive transparent ITO film by the direct current (dc) magnetron sputtering method, it was found that the partial gas pressure of H2O affected the properties of deposited films. When the substrate temperature is at or below 200 °C, the control of H2O partial gas pressure is especially important. Using room temperature substrates, an addition of 2×10−5 Torr of H2O in the sputtering process could form ITO films with good repeatability at a low resistivity of 6.0×10−4 Ω cm. By adding H2O gas, it was possible to solve the issue of increased resistivity in thicker films. The films with added H2O gas have H element immersed into the film and have high carrier concentration. Film transmittance stayed constant with or without H2O gas addition. Similar effect was observed by adding H2 gas instead of H2O gas.
The Effect of Active Delay Element Resistance on Limiting Heavy Ion SEU Upset Cross-Sections of SOI ADE/SRAMs (2007)

This paper discusses the effective limiting heavy-ion induced single-event upset cross section of radiation-hardened 150 nm SOI SRAM and the resistance of the active-delay element (ADE) used in the memory cell. The effective limiting upset cross-section of ADE/SRAM is found to be proportional to the product of the limiting upset cross-section of the 6T SRAM of the same CMOS technology and a dimensionless function of the normalized ADE resistance. In addition, a cross-section higher than this effective limiting cross-section at high effective LET (>250 MeV-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /mg) is observed. This additional contribution to the cross-section is attributed to the upset caused by the high effective LET heavy ion hitting the on-transistor in the memory cell.
Towards a Unified Theory of State Abstraction for MDPs. (2006)

extensively studied in the fields of artificial intelligence and operations research. Instead of working in the ground state space, the decision maker usually finds solutions in the abstract state space much faster by treating groups of states as a unit by ignoring irrelevant state information. A number of abstractions have been proposed and studied in the reinforcement-learning and planning literatures, and positive and negative results are known. We provide a unified treatment of state abstraction for Markov decision processes. We study five particular abstraction schemes, some of which have been proposed in the past in di#erent forms, and analyze their usability for planning and learning.
Internet Based Workflow Management: Towards a Semantic Web (2002)

From the Publisher:
Internet-based business transactions can be broken down into a series of independent steps. This workflow often involves tools from an array of fields, such as network modeling, scheduling, distributed systems, artificial intelligence, software agents, and Java. This book serves as a single, comprehensive resource for IT practitioners and students that covers all these vital aspects of workflow management.
Cyber Physical Systems - Oriented Design of Cooperative Control for Vehicle Platooning (2017)

Platoon vehicles with communication capability can dynamically form a mobile wireless network on the road with two types of communications: vehicle to vehicle (V2V) and vehicle to infrastructure (V2I). This complex networked control system integrates computing, communication and control technologies being considered a platoon-based vehicular cyberphysical system (CPS), with a closed feedback loop between the cyber process and the physical one. Platoon control using vehicular communication notably improves traffic safety and efficiency. In this paper, an application of cooperative platoonbased vehicular CPS with V2V communications is presented. The networked control architecture is of a Cooperative Adaptive Cruise Control (CACC) type where the vehicle only communicates with the preceding one. The standard control structure of the CACC system is composed of a PID CC controller for the leader vehicle and for the follower vehicle a GPC ACC feedback controller with implicit feed-forward compensator. The networked controllers of the platoon CACC architecture are obtained using CPS-oriented design approaches and the performances were tested via simulation considering a platoon with a leader and 15 followers.
SYNTHESIS OF SOME NOVEL TETRAHYDRONAPHTHALENE BENZIMIDAZOLE DERIVATIVES (2001)

Retinoids, synthetic and natural analogues of a//-iram-retinoic acid (RA), exert their biological effects with responsive elements of DNA to promote on cell differentiation and proliferation and behave as potent adipogenic hormones. Herein, we describe the synthesis of a number of novel tetrahydrotetramethylnaphthalene benzimidazole derivatives as retinoids. Analogs were prepared as depicted in Scheme 1 and 2. As is evident from both shemes. a variety of tetrahydrotetramethylnaphthalene benzimidazole derivatives have been synthesized by using an appropiate NaHS0 3 addiction product
A magnetic tape oscillograph for power system analysis (1951)

A unique magnetic pickup device makes the magnetic tape recorder adaptable to the recording of power system transient phenomena. Besides eliminating the inconvenience and expense of conventional photographic methods, this technique produces a permanent record starting well in advance of the transient being recorded.
N-Type Organic Semiconductors Based on π-Deficient Pentacenequinones: Synthesis, Electronic Structures, Molecular Packing, and Thin Film Transistors (2010)

Quinones are well-known as organic oxidizing reagents in organic synthesis and biological systems, but their ability of accepting electrons was rarely explored in connection with n-type organic semiconductors. Here, we report a comprehensive study on two groups of π-deficient pentacenequinones, fluorinated pentacenequinones and N-heteropentacenequinones, highlighting their electronic structures, molecular packing, and n-channel thin film transistors. It is found that replacing H atoms of pentacenequinone with F atoms or replacing C atoms with N can lower the lowest unoccupied molecular orbital (LUMO) energy level of pentacenequinone to yield n-type organic semiconductors with the field effect mobility up to higher than 0.1 cm2V−1s−1 in thin film transistors. A comparison between the two groups of quinones in terms of their electronic structures and molecular packing has led to interesting findings on the roles of electron-withdrawing moieties in tuning frontier molecular orbitals and π-stacking. Another interesting finding on the molecular packing is the quadruple weak hydrogen bonds, which link the neighboring π-stacks of quinones. This study suggests that π-deficient quinones would be a general design for n-type organic semiconductors.
Current Ovarian Cancer Maintenance Strategies and Promising New Developments (2020)

While ovarian cancer typically responds well to front line treatment, many patients will relapse within 5 years. Treatment options are less effective at each recurrence highlighting the need for novel maintenance therapies. PolyADP-ribose polymerase (PARP) inhibitors have recently gained approval in ovarian cancer maintenance. Niraparib was approved regardless of <i>BRCA</i> mutation status, however impact on overall survival is limited. Oliparib was approved for <i>BRCA</i> mutant and <i>BRCA</i> wildtype/homologous recombination deficient patients. This review will focus on current frontline ovarian cancer treatment as well molecularly based approaches to ovarian cancer management.
MPEG-7 Systems: overview (2001)

This paper gives an overview of Part 1 of ISO/IEC 15939 (MPEG-7 Systems). It first presents the objectives of the MPEG-7 Systems activity. In the MPEG-1 and MPEG-2 standards, "Systems" referred only to overall architecture, multiplexing, and synchronization. In MPEG-4, in addition to these issues, the Systems part encompasses interactive scene description, content description, and programmability, MPEG-7 brings new challenges to the Systems expertise, such as languages for description representation, binary representation of descriptions, and delivery of descriptions either separate or jointly with the audio-visual content. The paper then presents the description of the MPEG-7 Systems specification, starting from the general architecture up to the description of the individual MPEG-7 Systems tools. Finally, a conclusion describes the status of the standardization effort, as well as future extensions of the specification.
Experimental Data-Driven Parameter Identification and State of Charge Estimation for a Li-Ion Battery Equivalent Circuit Model (2018)

It is well known that accurate identification of the key state parameters and State of Charge (SOC) estimation method for a Li-ion battery cell is of great significance for advanced battery management system (BMS) of electric vehicles (EVs), which further facilitates the commercialization of EVs. This study proposed a systematic experimental data-driven parameter identification scheme and an adaptive extended Kalman Filter (AEKF)-based SOC estimation algorithm for a Li-Ion battery equivalent circuit model in EV applications. The key state parameters of Li-ion battery cell were identified based on the second-order resistor capacitor (RC) equivalent circuit model and the experimental battery test data using genetic algorithm (GA). Meanwhile, the proposed parameter identification procedure was validated by carrying out a comparative study of the simulated and experimental output voltage under the same input current profile. Then, SOC estimation was performed based on the AEKF algorithm. Finally, the effectiveness and feasibility of the proposed SOC estimator was verified by loading different operating profiles.
Automated Multivariate Calibration in Sequential Injection-Fourier Transform Infrared Spectroscopy for Sugar Analysis (1998)

Two approaches for automated preparation of a multicomponent calibration solution in sequential injection analysis (SIA) using one single standard for each component are proposed. The key to both approaches is the generation of highly reproducible injection sequences in the flow system. In the first approach, single standards of three different components are stacked in the holding coil in well-defined sequences. Upon flow reversal and transport to the detector, the stacked zones disperse into each other producing exactly defined mixtures of the three standards which can be recorded as a function of time. The second approach is based on complete mixing of the three single standards in different ratios prior to detection. For this purpose, repeated short sequences of small volumes of standard and distilled water are aspirated into the holding coil, which results in a homogeneous calibration solution upon flow reversal and transport to the detector. The proposed approaches have been applied to simultaneous determination of glucose, fructose, and sucrose in aqueous standards as well as in soft drinks using Fourier transform infrared spectroscopic detection and multivariate partial least-squares data analysis. The obtained results were compared with external reference methods to confirm the results obtained by the multivariate SIA-FTIR technique. Typical deviations from the results obtained by the reference method were in the order of 2.5, 4.4, and 2.8 g/L (2.5, 4.1, and 2.1% of total sugar) for glucose, fructose, and sucrose, respectively.
Treatment of poor-risk myelodysplastic syndromes and acute myeloid leukemia with a combination of 5-azacytidine and valproic acid (2011)

5-azacytidine (AZA) has become standard treatment for patients with higher-risk myelodysplastic syndrome (MDS). Response rate is about 50% and response duration is limited. Histone deactylase (HDAC) inhibitors are attractive partners for epigenetic combination therapy. We treated 24 patients with AZA (100 mg/m(2), 5 days) plus valproate (VPA; continuous dosing, trough serum level 80-110 μg/ml). According to WHO classification, 5 patients had MDS, 2 had MDS/MPD, and 17 had acute myeloid leukemia (AML). Seven patients (29%) had previously received intensive chemotherapy, and five had previous HDAC inhibitor treatment. The overall response rate was 37% in the entire cohort but significantly higher (57%) in previously untreated patients, especially those with MDS (64%). Seven (29%) patients achieved CR (29%) and two PR (8%), respectively. Hematological CR was accompanied by complete cytogenetic remission according to conventional cytogenetics in all evaluable cases. Some patients also showed complete remission according to FISH on bone marrow mononuclear cells and CD34(+) peripheral blood cells, as well as by follow-up of somatic mitochondrial DNA mutations. Four additional patients achieved at least marrow remissions. Factors influencing response were AML (vs. MDS), marrow blast count, pretreatment, transfusion dependency, concomitant medication with hydroxyurea, and valproic acid (VPA) serum level. This trial is the first to assess the combination of AZA plus VPA without additional ATRA. A comparatively good CR rate, relatively short time to response, and the influence of VPA serum levels on response suggest that VPA provided substantial additional benefit. However, the importance of HDAC inhibitors in epigenetic combination therapy can only be proven by randomized trials.
Semantic mapping support in AutomationML (2014)

In production system engineering, the machine-understandable definition of relations between engineering information views is important to enable automating dependency checking between these views. Unfortunately, in automation engineering there is no standardized representation of relations and dependencies, which makes it difficult to automate consistency checking. In this paper we derive requirements for describing relations and dependencies in the semantics of typical engineering models. We investigate the emerging data exchange standard AutomationML regarding the representation of semantic mapping types that represent relations and dependencies between engineering models. Major result is the identification on how semantic mapping types are modeled in AutomationML to find similarities and differences, which can help to improve the machine-understandable modeling of the dependencies in AutomationML to enable the automation of engineering processes.
A revision of CIECAM97s for practical applications (2001)

Abstract The CIE 1997 Interim Color Appearance Model (Simple Version), abbreviated CIECAM97s, was proposed by CIE TC1‐34 in 1997 in response to the needs of the imaging industry for a single, practically applicable, color appearance model for device‐independent color imaging applications. CIECAM97s has been successful in focusing a large number of researchers on a single direction to implement, evaluate, and suggest improvements for a single CIE model. However, CIECAM97s has been less successful in achieving the goal of being practically applicable. CIECAM97s remains a complex color appearance model, and this complexity seems to be somewhat of a barrier for its widespread adoption and use. CIE TC8‐01 is currently working toward recommendations for practical application of CIECAM97s. Part of TC8‐01's work is the consideration and evaluation of potential revisions and simplifications of CIECAM97s. This article incorporates several previously proposed enhancements of CIECAM97s and a few new suggestions into a revised model for the consideration of TC8‐01. It is hoped that this revision will aid in focusing ongoing model tests and perhaps be the starting point for a new CIE recommendation, once sufficient testing and perhaps further refinements are completed. © 2001 John Wiley & Sons, Inc. Col Res Appl, 26, 418–427, 2001
T Cell Responses Induced by Adenoviral Vectored Vaccines Can Be Adjuvanted by Fusion of Antigen to the Oligomerization Domain of C4b-Binding Protein (2012)

Viral vectored vaccines have been shown to induce both T cell and antibody responses in animals and humans. However, the induction of even higher level T cell responses may be crucial in achieving vaccine efficacy against difficult disease targets, especially in humans. Here we investigate the oligomerization domain of the α-chain of C4b-binding protein (C4 bp) as a candidate T cell "molecular adjuvant" when fused to malaria antigens expressed by human adenovirus serotype 5 (AdHu5) vectored vaccines in BALB/c mice. We demonstrate that i) C-terminal fusion of an oligomerization domain can enhance the quantity of antigen-specific CD4(+) and CD8(+) T cell responses induced in mice after only a single immunization of recombinant AdHu5, and that the T cells maintain similar functional cytokine profiles; ii) an adjuvant effect is observed for AdHu5 vectors expressing either the 42 kDa C-terminal domain of Plasmodium yoelii merozoite surface protein 1 (PyMSP1(42)) or the 83 kDa ectodomain of P. falciparum strain 3D7 apical membrane antigen 1 (PfAMA1), but not a candidate 128kDa P. falciparum MSP1 biallelic fusion antigen; iii) following two homologous immunizations of AdHu5 vaccines, antigen-specific T cell responses are further enhanced, however, in both BALB/c mice and New Zealand White rabbits no enhancement of functional antibody responses is observed; and iv) that the T cell adjuvant activity of C4 bp is not dependent on a functional Fc-receptor γ-chain in the host, but is associated with the oligomerization of small (<80 kDa) antigens expressed by recombinant AdHu5. The oligomerization domain of C4 bp can thus adjuvant T cell responses induced by AdHu5 vectors against selected antigens and its clinical utility as well as mechanism of action warrant further investigation.
Higher body mass index is associated with plantar fasciopathy/‘plantar fasciitis’: systematic review and meta-analysis of various clinical and imaging risk factors (2015)

We found a consistent clinical association between higher BMI and plantar fasciopathy. This association may differ between athletic and non-athletic subgroups. While consistent evidence supports a range of bone and soft tissue abnormalities, there is lack of evidence for the dogma of clinical and mechanical measures of foot and ankle function. Clinicians can use this information in shared decision-making.
Purification and Specificity of Cellobiose Phosphorylase from Clostridium thermocellum (1968)

Abstract A nonspecific cellobiose phosphorylase from Clostridium thermocellum, which has been purified over 100-fold, is active on 10 different glucosyl acceptors, d-glucose, 2-deoxyglucose, 6-deoxyglucose, d-glucosamine, d-mannose, d-altrose, l-galactose, l-fucose, d-arabinose, and d-xylose. Following electrophoresis on polyacrylamide gels, the activity with various acceptors occurs at the location of the major protein component, indicating that a single enzyme catalyzes these reactions. The pH optimum is about 6.5 with d-xylose as an acceptor. The relative Vmax and apparent Km values are 202 and 9.2 mm for 6-deoxyglucose, 100 and 35 mm for d-xylose, 53 and 73 mm for 2-deoxyglucose, 31 and 9.5 mm for d-glucosamine, 22 and 85 mm for d-mannose, 9 and 240 mm for d-arabinose and 8 and 160 mm for l-fucose. The Ki for d-glucose is 1.2 mm. The apparent Km value is 7.3 mm for cellobiose and 2.9 mm for Pi.
Profilin I is essential for cell survival and cell division in early mouse development (2001)

Profilins are thought to play a central role in the regulation of de novo actin assembly by preventing spontaneous actin polymerization through the binding of actin monomers, and the adding of monomeric actin to the barbed actin-filament ends. Other cellular functions of profilin in membrane trafficking and lipid based signaling are also likely. Binding of profilins to signaling molecules such as Arp2/3 complex, Mena, VASP, N-WASP, dynamin I, and others, further implicates profilin and actin as regulators of diverse motile activities. In mouse, two profilins are expressed from two distinct genes. Profilin I is expressed at high levels in all tissues and throughout development, whereas profilin II is expressed in neuronal cells. To examine the function of profilin I in vivo, we generated a null profilin I (pfn1(ko)) allele in mice. Homozygous pfn1(ko/ko) mice are not viable. Pfn1(ko/ko) embryos died as early as the two-cell stage, and no pfn1(ko/ko) blastocysts were detectable. Adult pfn1(ko/wt) mice show a 50% reduction in profilin I expression with no apparent impairment of cell function. However, pfn1(ko/wt) embryos have reduced survival during embryogenesis compared with wild type. Although weakly expressed in early embryos, profilin II cannot compensate for lack of profilin I. Our results indicate that mouse profilin I is an essential protein that has dosage-dependent effects on cell division and survival during embryogenesis.