gebhart/patrepeval huggingface dataset:
The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men. (1994)

The relationships of cigarette smoking, age, relative weight, and dietary intake to serum dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), androstenedione, cortisol, 3-alpha-androstanediol, 3-alpha-androstanediol-glucuronide, testosterone, albumin-bound testosterone, free testosterone, dihydrotestosterone (DHT), and sex hormone-binding globulin (SHBG) were examined cross-sectionally in 1241 randomly sampled middle-aged U.S. men. Compared with nonsmokers and independent of relative weight (body mass index) and age, cigarette smokers had increased serum levels of DHEA (18% higher, P = 0.0002), DHEAS (13% higher, P = 0.0007), cortisol (5% higher, P = 0.01), androstenedione (33% higher, P = 0.0001), testosterone (9% higher, P = 0.009), DHT (14% higher, P = 0.004), and SHBG (8% higher, P = 0.004). Androstenedione, total plasma testosterone, albumin-bound testosterone, DHT, and SHBG decreased with increasing relative weight. Age was positively associated with serum SHBG and negatively associated with albumin-bound testosterone, DHEA, and DHEAS. An association was found between alcohol intake and DHEA (r = 0.15; P = 0.0001), cortisol (r = 0.10; P = 0.0007), and 3-alpha-androstanediol-glucuronide (r = 0.08; P = 0.0004). Cortisol was the only hormone that was associated with carbohydrate intake (r = -0.09; P = 0.002). The only hormones associated with dietary lipids were DHT (for vegetable fat, r = 0.07; P = 0.02), cortisol (for total fat, r = 0.08; P = 0.007), and SHBG (for animal fat, r = -0.06; P = 0.05). In addition, SHBG was positively associated with dietary (r = 0.07; P = 0.008) and crude (r = 0.08; P = 0.007) fiber. These data suggest that serum adrenal steroid and sex hormone concentrations in middle-aged men are more influenced by cigarette smoking, age, and obesity than by dietary intake; however, serum adrenal steroids were influenced by alcohol intake.
Auditory perception versus automatic estimation of location and orientation of an acoustic source in a real environment (2010)

In this work, the perception of the position and orientation of a directional acoustic source in a real enclosed environment by blindfolded listeners is investigated and compared with a method that automatically estimates the position and orientation of the source using a T-shaped microphone array. In the subjective experiment using blindfolded listeners, a human speaker acted as an acoustic source and listeners judged the speaker’s facing angle (one out of four possible orientations shifted by 90°) and position after listening to a spoken sentence. This procedure was performed twice, before and after a training phase. In the training, listeners were allowed to remove the blindfold and verify the speaker’s position and orientation. After the training, the correct orientation ratio increased from 75.0 to 76.5% and the average position error decreased from 66.2 to 60.6 cm. In addition, a subjective experiment on orientation estimation with eight orientations shifted by 45° in the same real environment showed that orientation estimation in a real environment was more difficult than that in an anechoic environment. Artificial neural networks (ANNs) were used in the automatic estimation method. A correct orientation ratio of 68.1% and an average position error of 48.0 cm were obtained by the T-shaped microphone array located nearest to the blindfolded listener among an array network consisting of eight T-shaped microphone arrays, enabling a rough comparison between human auditory perception and the automatic estimation method (a correct orientation ratio of 67% and a better average position error of 38.6 cm were the best results obtained by a T-shaped array in the network). It was clarified that the automatic estimation method cannot surpass the auditory system in terms of correct orientation ratio; however, it yielded better results in terms of the average position error.
Post‐Tonsillectomy Morbidity and Quality of Life in Pediatric Patients with Obstructive Tonsils and Adenoid: Microdebrider vs Electrocautery (2006)

A-1b.
NANOPARTICLES AS A NOVEL DELIVERY VEHICLE FOR THERAPEUTICS TARGETING ERECTILE DYSFUNCTION (2009)

You have accessJournal of Urology1 Apr 2009NANOPARTICLES AS A NOVEL DELIVERY VEHICLE FOR THERAPEUTICS TARGETING ERECTILE DYSFUNCTION Kelvin P Davies, George Han, Moses Tar, Adam Friedman, Arnold Melman, and Joel Friedman Kelvin P DaviesKelvin P Davies More articles by this author , George HanGeorge Han More articles by this author , Moses TarMoses Tar More articles by this author , Adam FriedmanAdam Friedman More articles by this author , Arnold MelmanArnold Melman More articles by this author , and Joel FriedmanJoel Friedman More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60676-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "NANOPARTICLES AS A NOVEL DELIVERY VEHICLE FOR THERAPEUTICS TARGETING ERECTILE DYSFUNCTION." The Journal of Urology, 181(4S), p. 238 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 238 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetrics Author Information Kelvin P Davies More articles by this author George Han More articles by this author Moses Tar More articles by this author Adam Friedman More articles by this author Arnold Melman More articles by this author Joel Friedman More articles by this author Expand All Advertisement PDF downloadLoading ...
Syndiotactic Poly(methyl methacrylate) (sPMMA)−Polybutadiene (PBD)−sPMMA Triblock Copolymers:  Synthesis, Morphology, and Mechanical Properties (1996)

A series of syndiotactic poly(methyl methacrylate) (sPMMA)−polybutadiene (PBD)−sPMMA triblock copolymers, or MBM, have been successfully synthesized by using dilithium initiators (DLi's) based on the diadduct of tert-butyllithium (t-BuLi) to either 1,3-bis(1-phenylethenyl)benzene (PEB) or m-diisopropenylbenzene (m-DIB). The efficiency of these DLi's in building up MBM triblock copolymers has been compared under the same experimental conditions, i.e., in a cyclohexane/diethyl ether mixture for the butadiene polymerization at room temperature and in a cyclohexane/THF mixture for the MMA polymerization at −78 °C. Although all the synthesized copolymers show a monomodal, symmetric, and very narrow molecular weight distribution, the MBM copolymers synthesized with the m-DIB/t-BuLi diadduct are pure triblocks and show a high tensile strength, in contrast to copolymers initiated by the PEB/t-BuLi diadducts that are of a lower tensile strength and contaminated by MB diblock copolymers. Solvent cast films of MBM prepared with the m-DIB/t-BuLi diadduct are two-phase materials as confirmed by DSC and dynamic mechanical analysis (DMA). Transmission electron microscopy (TEM) shows a spherical morphology at a low sPMMA content, that changes into a cylindrical and finally lamellar morphology upon increasing the sPMMA content. Phase separation is observed for MBM with M̄n of the sPMMA blocks as low as 6000. Dependence of tensile strength on copolymer structure and sample preparation has been studied. The smaller sPMMA molecular weight, M̄n(PMMA), required for high tensile strength depends on the PBD molecular weight, M̄n(PBD), e.g. 12 000 for Mn(PBD) = 36 000 and 6000 for Mn(PBD) = 80 000. The upper M̄n(PMMA) is ca. 20−25 000, whatever the Mn(PBD). The optimum tensile strength is observed for M̄n(PMMA) = 15 000, independently of Mn(PBD) in the studied range. As a rule, the tensile strength tends to level off and the elongation at break starts to decrease when the sPMMA content is increased beyond 35 wt %. At a constant sPMMA content, Mn(PBD) (>ca. 36 000) does not affect the ultimate tensile properties.
ChemInform Abstract: Enantioselectivity of a Recombinant Epoxide Hydrolase from Agrobacterium radiobacter. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Long-Term Retrospective Follow-Up of Fresh Osteochondral Allograft Transplantation for Steroid-Associated Osteonecrosis of the Femoral Condyles (2018)

Our findings suggest that OCA transplantation is a reasonable surgical treatment option for steroid-associated osteonecrosis of the femoral condyles, with durable long-term outcomes.
Thermal distortion analysis on ACTS multibeam antenna (2003)

The on-orbit antenna system performance under worst-case thermal distortion is analyzed. The parameters under consideration are beam shift, peak gain, and edge of coverage (EOC) gain degradation for co-aligned multiple beams on separate receive and transit antennas. The analytical method and a method to minimize the thermal distortion effects are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The binding of tetrodotoxin to nerve membranes (1971)

1. The% reduction in size of the externally recorded action potential produced by concentrations of tetrodotoxin (TTX) in the range 6-300 nM was determined for the small non-myelinated fibres of the rabbit cervical vagus nerve and of the walking leg nerves of crab and lobster. The concentration of TTX for 50% reduction was around 80 nM for rabbit vagus and 14 nM for crab nerve.2. Bio-assay procedures were devised to measure the amount of TTX taken up by a nerve when it was exposed to a very small volume of a solution whose TTX content was just great enough to produce 100% block of conduction. The extracellular space of each nerve was determined with [(14)C]sugar so that an allowance could be made for extracellular dilution.3. The TTX binding by rabbit, crab and lobster nerve was respectively 0.064, 0.053 and 0.036 p-mole/mg wet weight of nerve.4. The binding of saxitoxin was measured in rabbit vagus nerve, and found to be much the same as that of TTX.5. Control experiments on rabbit sciatic nerve, where the area of excitable membrane was much smaller, showed that there was relatively little unspecific binding of TTX.6. In view of the evidence presented here and elsewhere that the blocking of sodium conductance by TTX involves the attachment of only one TTX molecule at each sodium site, and that unspecific binding of TTX does not cause serious errors, these results suggest that in 1 mum(2) of nerve membrane the number of sodium sites is 75 for rabbit, 49 for crab, and 36 for lobster nerve.
Why Deep Learning Works: A Manifold Disentanglement Perspective (2015)

Deep hierarchical representations of the data have been found out to provide better informative features for several machine learning applications. In addition, multilayer neural networks surprisingly tend to achieve better performance when they are subject to an unsupervised pretraining. The booming of deep learning motivates researchers to identify the factors that contribute to its success. One possible reason identified is the flattening of manifold-shaped data in higher layers of neural networks. However, it is not clear how to measure the flattening of such manifold-shaped data and what amount of flattening a deep neural network can achieve. For the first time, this paper provides quantitative evidence to validate the flattening hypothesis. To achieve this, we propose a few quantities for measuring manifold entanglement under certain assumptions and conduct experiments with both synthetic and real-world data. Our experimental results validate the proposition and lead to new insights on deep learning.
Optimizing and Improving the Sodium Ion Conductivity of Nasicon (2016)

NASICON (Na 3 Zr 2 Si 2 PO 12 ) has shown promise as a solid state electrolyte for a sodium battery due to its inherent safety and relatively high conductivity. Increasing the conductivity of NASICON to further improve the capability of a solid state electrolyte has come by way aliovalent substitution of the zirconium site in Na 3 Zr 2 Si 2 PO 12 . Both Na 3.2 Zr 1.8 M 0.2 Si 2 PO 12 (M=Al 3+ , Fe 3+ , Y 3+ ) and Na 3.4 Zr 1.8 M 0.2 Si 2 PO 12 (M=Co 2+ , Ni 2+ , Zn 2+ ) have exhibited greater bulk conductivity at room temperature than undoped NASICON. A decrease in low temperature activation energy as well as the lowered rhombohedral-monoclinic phase transformation temperature is responsible for the increased bulk conductivity of substituted NASICON. The Co, Zn, and Ni dopants were explored more extensively as they displayed the highest conductivity of 10% doped NASICON at room temperature. By adjusting the total substitution of Co, Zn, and Ni cations, the conductivity of NASICON was optimized further. Increasing the amount of Zn +2 dopant in Na 3+2x Zr 2-x Zn x Si 2 PO 12 resulted in reduced distortion of the lattice as it transitioned from rhombohedral to monoclinic phase, and an increase in conductivity. Ultimately the bulk ionic conductivity of 20% Zn-doped NASICON is among the highest ever reported.
Non Platinum Metal Complexes as Anti‐cancer Drugs (2007)

The development of metal complexes with platinum central atoms such as cisplatin or carboplatin had an enormous impact on current cancer chemotherapy. However, the spectrum of cancers that can be treated with platinum agents is narrow and treatment efficacy suffers from side effects and resistance phenomena. These unresolved problems in platinum-based anti-cancer therapy have stimulated increased research efforts in the search for novel non platinum-containing metal species as cytostatic agents. Preclinical and clinical investigations showed that the development of new metal agents with modes of action different from cisplatin is possible. Thus, complexes with iron, cobalt, or gold central atoms have shown promising results in preclinical studies and compounds with titanium, ruthenium, or gallium central atoms have already been evaluated in phase I and phase II trials. This review covers some relevant examples of preclinical and clinical research on novel non platinum metal complexes.
Homozygous Mutations in PXDN Cause Congenital Cataract, Corneal Opacity, and Developmental Glaucoma (2011)

Anterior segment dysgenesis describes a group of heterogeneous developmental disorders that affect the anterior chamber of the eye and are associated with an increased risk of glaucoma. Here, we report homozygous mutations in peroxidasin (PXDN) in two consanguineous Pakistani families with congenital cataract-microcornea with mild to moderate corneal opacity and in a consanguineous Cambodian family with developmental glaucoma and severe corneal opacification. These results highlight the diverse ocular phenotypes caused by PXDN mutations, which are likely due to differences in genetic background and environmental factors. Peroxidasin is an extracellular matrix-associated protein with peroxidase catalytic activity, and we confirmed localization of the protein to the cornea and lens epithelial layers. Our findings imply that peroxidasin is essential for normal development of the anterior chamber of the eye, where it may have a structural role in supporting cornea and lens architecture as well as an enzymatic role as an antioxidant enzyme in protecting the lens, trabecular meshwork, and cornea against oxidative damage.
The WI-1 antigen of <i>Blastomyces dermatitidis</i> yeasts mediates binding to human macrophage CD11b/CD18 (CR3) and CD14. (1995)

Three genetically related strains of Blastomyces dermatitidis (Bd) yeasts that differ in their expression of WI-1, an immunodominant cell wall Ag, were tested for their capacity to bind to human macrophages (M phi) in the absence of serum. These strains included American Type Culture Collection (ATCC, Rockville, MD) ATCC 26199, which is virulent for mice; an attenuated mutant strain ATCC 60915, which expresses 2.5-fold more WI-1 than strain 26199; and an avirulent mutant strain, ATCC 60916, which has sixfold more WI-1 than strain 26199. Attachment of both mutant strains to M phi was rapid and was maximum after 10 min at 37 degrees C. Attachment of strain 26199 to M phi was approximately 40% of that obtained with the mutants. Binding of Bd to M phi was temperature- and Mg(2+)-dependent, and heat-killed yeasts bound to M phi as well as viable yeasts. Experiments with receptor-specific mAbs demonstrated that 26199 yeasts bound predominantly to the LPS binding site on CD11b/CD18 (CR3). However, the mutants bound to M phi CD14 as well as CR3. Fab anti-WI-1 inhibited the binding of all strains to M phi by 69 to 78%. Latex microspheres coated with purified WI-1 or a 25-amino acid tandem repeat located within WI-1 also bound to M phi CR3 and CD14. These data demonstrate that: 1) WI-1 is a major ligand on Bd that mediates attachment of yeasts to human M phi; 2) the binding activity of WI-1 is located within the 25-amino acid tandem repeat; and 3) binding of Bd yeasts to M phi is mediated through the LPS binding site on CR3 and CD14.
Influence of Methylenetetrahydrofolate Reductase Gene Polymorphisms on Homocysteine Concentrations after Nitrous Oxide Anesthesia (2008)

This study shows that patients with a homozygous MTHFR 677C>T or 1298A>C mutation are at a higher risk of developing abnormal plasma homocysteine concentrations after nitrous oxide anesthesia.
Ring sensor and heart rate monitoring system for sensor network applications (2008)

A ring-type pulse oximeter sensor attached to the finger and its 24-hour ambulatory heart rate monitoring system are presented. The PCB has been designed with a light-to-frequency converter and the CPU with a built-in Zigbee stack for simple and low power consumption. Also designed is the algorithm using a least square estimator to calibrate various signal distortions caused by motion artefacts for a proper accuracy.
Nucleotide sequence of two<i>ras</i><sup>H</sup>related-genes isolated from the yeast<i>Saccharomyces cerevisiae</i> (1984)

A complete nucleotide sequence of two ras-related yeast genes (c- rassc -1 and c- rassc -2) isolated from the yeast strain Saccharomyces cerevisiae is reported. They encode predicted polypeptides of 40,000 and 41,000 daltons, respectively. The N-terminal 170 amino acids from both genes show extensive amino acid homology to other ras genes from vertebrates, whereas their C-termini have diverged. These genes should be useful in the elucidation of a normal biological function of ras-related genes in a simple system like yeast.
Laser coronary recanalization in human patients (1984)

Since our last report1 we have used the argon laser catheter in five human patients during the period 17-21 Sept. 1983 in Toulouse, France. All five patients had 75-95% stenotic lesions in main coronary arteries due to arteriosclerotic plaque. There were two left anterior descending and three right coronary arteries. All patients were undergoing coronary artery bypass graft surgery.
The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review) (2015)

The collagen receptor uPARAP/Endo180, the product of the MRC2 gene, is a central component in the collagen turnover process governed by various mesenchymal cells. Through the endocytosis of collagen or large collagen fragments, this recycling receptor serves to direct basement membrane collagen as well as interstitial collagen to lysosomal degradation. This capacity, shared only with the mannose receptor from the same protein family, endows uPARAP/Endo180 with a critical role in development and homeostasis, as well as in pathological disruptions of the extracellular matrix structure. Important pathological functions of uPARAP/Endo180 have been identified in various cancers and in several fibrotic conditions. With a particular focus on matrix turnover in cancer, this review presents the necessary background for understanding the function of uPARAP/Endo180 at the molecular and cellular level, followed by an in-depth survey of the available knowledge of the expression and role of this receptor in various types of cancer and other degenerative diseases.
Apparatus for the Precision Measurement of Internal Friction (1968)

An apparatus, which permits routine measurement of internal friction as low as 2×10−7 and Young's modulus as a function of temperature, frequency, and strain amplitude in extremely low loss materials, is presented. The system described herein can be used to investigate a variety of materials and is not hampered by the limitations placed upon composite resonator systems. It has been successfully used to study internal friction in the amplitude-independent and amplitude-dependent regions in pure and CaCl2-doped NaCl.
Irreversibility of Single Electron Transfer Occurring from Trivalent Phosphorus Compounds to Iron(III) Complexes in the Presence of Ethanol (2002)

Abstract Various types of trivalent phosphorus compounds (1; Ph(3-n)P(OR)n) underwent single electron transfer (SET) to unsubstituted (2H) and 5-chloro-substituted tris(1, 10-phenanthroline)iron(III) complexes (2Cl) in the presence of ethanol in acetonitrile, resulting in the reduction of 2 to the corresponding iron(II) complexes. The rate constants (kp) for the overall SET process were determined spectrophotometrically to show that within each series of 1 with an identical alkoxy group OR, log kp correlates linearly with the difference in the half-wave potentials (ΔE1/2) between 1 and 2. The slope of each correlation line gave an α-value for each series of 1. The α-values were significantly smaller than unity, indicating that the SET step is irreversible, even though this step is endothermic. The trivalent phosphorus radical cation 1•+ generated in the SET step undergoes a rapid ionic reaction with ethanol, which is certainly the origin of the irreversibility. Upon examining the α-values more closely, it was found that the transition state of the SET step becomes earlier with increasing bulkiness of the substituent OR. It is concluded that 1 and 2 form a tight encounter complex to undergo SET from the former to the latter.
Subfractionation of S<sub>f</sub> 4–10<sup>5</sup>, S<sub>f</sub> 4–20 and high density lipoproteins (1972)

Abstract Subfractionation of the total low density S f 4–10 5 , the low density S f 4–20 and high density plasma (or serum) lipoproteins has been accomplished using a cumulative flotation rate procedure. Fractionation employs nonlinear salt gradients and high performance swinging bucket rotors. Subfractionation of the total low density lipoproteins with minimal contamination allows and extremely accurate lipoprotein mass measurement of S f > 400, total very low density lipoproteins and low density lipoproteins (LDL) by elemented CHN analysis. Physical and chemical data on LDL and high density lipoprotein (HDL) subfractions are in general agreement with earlier data. Lower molecular weight data are obtained for HDL subfractions than reported earlier; however this may be the result of the different fractionation procedures used.
Inhibition enhancer of zeste homologue 2 promotes senescence and apoptosis induced by doxorubicin in <i>p53</i> mutant gastric cancer cells (2014)

These data help unravel a crucial role for EZH2 in senescence and apoptosis in gastric cancer cells and that p53 genomic status was associated with different cell responses to EZH2 silencing.