gebhart/patrepeval huggingface dataset:
Vehicle Logo Recognition and attributes prediction by multi-task learning with CNN (2016)

Vehicle Logo Recognition(VLR) has been an important study field in intelligent Transportation system (ITS). This paper proposes to recognize vehicle logo and predict logo attributes by combining Convolutional Neural Network (CNN) with Multi-Task Learning(MTL). In order to accelerate convergence of multi-task model, an adaptive weight training strategy is employed. To verify the algorithm, the Xiamen University Vehicle logo recognition dataset is extended into a larger vehicle logo dataset including 15 brands, 6 visual attributes and 3 no-visual attributes. The experiment results indicate that the proposed multi-task CNN model perform well for both of logo classification and attribution prediction with overall accuracy 98.14%.
Tactile recognition by probing: identifying a polygon on a plane (1986)

An outstanding problem in model-based recognition of objects by robot systems is how the system should proceed when the acquired data are in8ufRcient to identify uniquely the model instance and model pose that best interpret the object. In this paper, we consider the situation in which some tactile data about the object are already available, but can be ambiguously interpreted. The problem is thus to acquire and process new tactile data in a sequential and eflicient manner, so that the object can be recognised and its location and orientation determined. An object model, in this initial analysis of the problem, is a polygon located on a plane; the case of planar objects present8 8ome in-teresting problems, and is also an important prelude to recognition of three-dimensional (polyhedral) objects. 1.
Chemotherapy in non-small cell lung cancer: Large trial will reduce uncertainty (1996)

istration is focusing on this in its "health in the next millennium" work programme, as is the Medical Research Council in its Gambia project, and the Liverpool School of Tropical Medicine now incorporates non-communicable diseases into its diploma courses.We suggest that the specialty of tropical medicine should shift towards a broader specialty of "health in developing countries," with the multidisciplinary inputs that the authors recommend, rather than be subsumed into infectious diseases.
Released protease-nexin regulates cellular binding, internalization, and degradation of serine proteases. (1981)

Protease-nexin (PN), a component released by normal human fibroblasts into culture medium, forms covalent linkages with thrombin (Th) and the urinary plasminogen activator urokinase, apparently with their catalytic site serines. The present studies explored the function of PN by examining the interaction of protease-PN complexes with human fibroblasts and the consequences of this interaction. Th-PN and urokinase-PN complexes bind to cells via the PN portion of the complexes. The binding is selectively inhibited by heparin. Because PN has a heparin-binding site, this indicates that protease-PN complexes might bind to a cellular heparin-like site. After binding, the complexes are internalized. By inhibiting endocytosis with phenylarsine oxide, which does not affect cellular binding of Th-PN complexes, we showed that complexes must be internalized before they are degraded. Kinetic analysis of internalization and degradation of Th-PN showed that complexes are internalized more rapidly than they dissociate from the cell surface; by 120 min of incubation at 37 degrees C most cell-bound Th-PN complexes are degraded to amino acids. The results are summarized in a model showing how PN mediates the cellular binding, internalization, and degradation of serine proteases through formation of protease-PN complexes. This series of events may be involved in the regulation of serine protease activity at the cell surface and in the extracellular environment.
Stable cw backward Raman amplification in optical fibers by stimulated Brillouin scattering suppression (1986)

A backward pumping scheme with highly repetitive short pump pulses is described for cw Raman amplification of signal light in optical fibers. This pumping scheme makes possible stable and high-gain cw Raman amplification due to the efficient suppression of stimulated Brillouin scattering, which not only limits the gain but also deteriorates the gain stability of such amplification. Stable cw backward Raman amplification of 1.4-μm laser diode light signals has been achieved, for the first time, with gains as high as 14 dB in a 5.5-μm core diam and 3.5-km long single-mode fiber, pumped with a 1.32-μm mode-locked Nd:YAG laser.
Automating the generation of coordinated multimedia explanations (1991)

An explanation system developed to overcome the disadvantages of conventional authoring in multimedia applications is presented. This experimental test bed for the automated generation of multimedia explanations is called COMET (coordinated multimedia explanation testbed), and has as its goal the coordinated, interactive generation of explanations that combine text and three-dimensional graphics, all of which is generated on the fly. In response to a user request for an explanation, COMET dynamically determines the explanation's content using constraints based on the type of request, the information available in a set of underlying knowledge bases, and information about the user's background and goals. Having determined what to say, COMET also determines how to express it at the time of generation. A brief overview of COMET's domain and architecture is followed by a description of the specific ways in which COMET can coordinate its text and graphics. The current status and limitations of COMET are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Low Power Sensor Networks (2001)

This chapter contains sections titled: Introduction Power-Aware Node Architecture Hardware Design Issues Signal Processing in the Network Signal Processing Algorithms Signal Processing Architectures Conclusions
CB<sub>1</sub>Receptors Mediate the Analgesic Effects of Cannabinoids on Colorectal Distension-Induced Visceral Pain in Rodents (2009)

Activation of cannabinoid receptors (CB(1), CB(2) and GPR(55)) produces analgesic effects in several experimental pain models, including visceral pain arising from the gastrointestinal tract. We assessed the role of CB(1), CB(2), and GPR(55) receptors and the endogenous cannabinoid system on basal pain responses and acute mechanical hyperalgesia during colorectal distension (CRD) in rodents. The effects of cannabinoid receptor agonists and antagonists on pain-related responses to CRD were assessed in rats and in wild-type and CB(1) receptor knock-out mice. The dual CB(1/2) agonist, WIN55,212-2, and the peripherally acting CB(1)-selective agonist, SAB-378, inhibited pain-related responses to repetitive noxious CRD (80 mmHg) in a dose-related manner in rats. The analgesic effects of WIN55,212-2 and SAB-378 were blocked by the selective CB(1) antagonist SR141716, but were not affected by the selective CB(2) antagonist SR144528. SR141716, per se, increased the responses to repetitive noxious CRD, indicative of hyperalgesia, and induced pain-related responses during non-noxious CRD (20 mmHg), indicative of allodynia. The cannabinoid receptor agonists anandamide, virodhamine and O-1602 had no effect. At analgesic doses, WIN55,212-2 did not affect colonic compliance. In accordance to the rat data, WIN55,212-2 produced analgesia, whereas SR141716 induced hyperalgesia, during noxious CRD (55 mmHg) in wild-type but not in CB(1)-knock-out mice. These data indicate that peripheral CB(1) receptors mediate the analgesic effects of cannabinoids on visceral pain from the gastrointestinal tract. The allodynic and hyperalgesic responses induced by SR141716 suggest the existence of an endogenous cannabinoid tone and the activation of CB(1) receptors during noxious CRD.
Decentralized decision support for intelligent manufacturing in Industry 4.0 (2017)

“Industry 4.0” is recognized as the future of industrial production in which concepts as Smart Factory and Decentralized Decision Making are fundamental. This paper proposes a novel strategy to support decentralized decision, whilst identifying opportunities and challenges of Industry 4.0 contextua lizing the potential that represents industrial digitalization and how technological advances can contribute for a new perspective on manufacturing production. It is analysed a set of barriers to the full implementation of Industry 4.0 vision, identifying areas in which decision support is vital. Then, for each of the identified areas, the authors propose a strategy, characterizing it together with the level of complexity that is involved in the different processes. The strategies proposed are derived from the needs of two of Industry 4.0 main characteristics: horizontal integration and vertical integration. For each case, decision approaches are proposed concerning the type of decision required (strategic, tactical, operational and real-time). Validation results are provided together with a discussion on the main challenges that might be an obstacle for a successful decision strategy.
Awakening with amantadine from a persistent vegetative state after subarachnoid haemorrhage (2017)

We report the case of a 36-year-old woman with a subarachnoid haemorrhage (SAH) caused by a rupture of a right-sided middle cerebral artery aneurysm and subsequent malignant infarction of the right hemisphere leading to a persistent vegetative state and severe spastic tetraparesis with recurrent myocloni. Nine months after disease onset, the patient was transferred to our department for diagnostic and therapeutic re-evaluation. The poor clinical condition could not be explained by the brain lesion caused by the SAH or infarction. Moreover, glucose metabolism was normal in brain regions not affected by SAH and infarction as shown by positron emission tomography with <sup>18</sup>F-fluorodeoxyglucose. We terminated baclofen and reduced antiepileptics known to impair vigilance and cognitive functions. However, only after starting amantadine treatment we observed a stunning awakening of the patient fully orientated within days. Our findings warrant trials to investigate amantadine in the treatment of unresponsive wakefulness syndromes due to acute central nervous system diseases.
Identification and Phenotypic Characterization of <i>Sphingomonas wittichii</i> Strain RW1 by Peptide Mass Fingerprinting Using Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (2005)

Mass spectrometry is a potentially attractive means of monitoring the survival and efficacy of bioaugmentation agents, such as the dioxin-mineralizing bacterium Sphingomonas wittichii strain RW1. The biotransformation activity of RW1 phenotypes is determined primarily by the presence and concentration of the dioxin dioxygenase, an enzyme initiating the degradation of both dibenzo-p-dioxin and dibenzofuran (DF). We explored the possibility of identifying and characterizing putative cultures of RW1 by peptide mass fingerprinting (PMF) targeting this characteristic phenotypic biomarker. The proteome from cells of RW1--grown on various media in the presence and absence of DF--was partially purified, tryptically digested, and analyzed using matrix-assisted laser desorption ionization-time of flight mass spectrometry. Mascot online database queries allowed statistically significant identification of RW1 in disrupted, digested cells (P < 0.01 to 0.05) and in digested whole-cell extracts (P < 0.00001 to 0.05) containing hundreds of proteins, as determined by two-dimensional gel electrophoresis. Up to 14 peptide ions of the alpha subunit of the dioxin dioxygenase (43% protein coverage) were detected in individual samples. A minimum of 10(7) DF-grown cells was required to identify dioxin degradation-enabled phenotypes. The technique hinges on the detection of multiple characteristic peptides of a biomarker that can reveal at once the identity and phenotypic properties of the microbial host expressing the protein. The results demonstrate the power of PMF of minimally processed microbial cultures as a sensitive and specific technique for the positive identification and phenotypic characterization of certain microorganisms used in biotechnology and bioremediation.
An algebraic approach to geometric query processing in CAD/CAM applications (1991)

Article Free Access Share on An algebraic approach to geometric query processing in CAD/CAM applications Authors: R. E. da Silva Graduate Research Assistant, Department of Mechanical Engineering, Austin, TX Graduate Research Assistant, Department of Mechanical Engineering, Austin, TXView Profile , K. L. Wood Assistant Professor, Department of Mechanical Engineering, Austin, TX Assistant Professor, Department of Mechanical Engineering, Austin, TXView Profile , J. J. Beaman Professor, University of Texas, Austin, Department of Mechanical Engineering, Austin, TX Professor, University of Texas, Austin, Department of Mechanical Engineering, Austin, TXView Profile Authors Info & Claims SMA '91: Proceedings of the first ACM symposium on Solid modeling foundations and CAD/CAM applicationsMay 1991 Pages 73–86https://doi.org/10.1145/112515.112532Online:01 May 1991Publication History 2citation360DownloadsMetricsTotal Citations2Total Downloads360Last 12 Months3Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Genetic variation in tree structure and its relation to size in Douglas-fir. II. Crown form, branch characters, and foliage characters (1994)

Genetic variation and covariation among traits of tree size and structure were assessed in an 18-year-old Douglas-fir (Pseudotsugamenziesii var. menziesii (Mirb.) Franco) genetic test in the Coast Range of Oregon. Considerable genetic variation was found for relative crown width; stem increment per crown projection area; leaf area and branch weight relative to crown size; branch diameter and length adjusted for stem size; branch stoutness; cross-sectional area of branches per crown length; and needle size. Little genetic variation was found for branch numbers per whorl, branch angle, and specific leaf area. At both the phenotypic and genetic level, large trees growing well relative to growing space had tall, narrow crowns, high leaf areas per crown projection area or branch length, greater partitioning to leaves versus branches, and stouter branches. Thus, large, efficient trees were those that invested more in the photosynthetic machinery of leaf area and the branch biomass necessary to support that leaf area, but distributed that leaf area over a greater vertical distance. Unfortunately, these traits also were associated with increased branchiness, and selection for these traits would be accompanied by reductions in harvest index and wood quality.
<i>In vitro</i> translation of androgen receptor cRNA results in an activated androgen receptor protein (1993)

Translation of androgen receptor (AR) cRNA in a reticulocyte lysate and subsequent analysis of the translation products by SDS/PAGE showed a protein with an apparent molecular mass of 108 kDa. Scatchard-plot analysis revealed a single binding component with high affinity for R1881 (Kd = 0.3 nM). All AR molecules synthesized specifically bound steroid. No evidence for AR phosphorylation during in vitro synthesis was found. When AR was labelled with [3H]R1881 and analysed on sucrose-density gradients, a complex of approx. 6 S was observed. The complex was shifted to a higher sedimentation coefficient after incubation with a monoclonal AR antibody directed against an epitope in the DNA-binding domain. In the presence as well as the absence of hormone, AR molecules were able to bind to DNA-cellulose without an activation step. Gel retardation assays revealed that the AR forms complexes with a DNA element containing glucocorticoid-responsive element/androgen-responsive element sequences. Receptor-DNA interactions were stabilized by different polyclonal antibodies directed against either the N- or C-terminal part of the AR and were abolished by an antibody directed against the DNA-binding domain of the receptor. In conclusion, translation of AR cRNA in vitro yields an activated AR protein which binds steroid with high affinity. It is proposed that AR antibodies enhance AR-DNA binding by stabilizing AR dimers when bound to DNA.
Darbepoetin alpha coming of age. (2008)

Anemia has a high prevalence and incidence in patients with cancer and is associated with a range of symptoms, including fatigue, which affect the vast majority patients receiving chemotherapy exerting a considerable impact on patients' quality of life. The development of the erythropoiesis-stimulating agent epoetin represented a major step forward in the treatment of chemotherapy-related anemia, providing an effective and safe alternative to red blood cell transfusions. The subsequently introduced epoetin analogue, darbepoetin alpha, with a prolonged serum half-life, allowed for extended dosing intervals and less frequent administration. Recently published large prospective trials provided the oncology community with new important information on the use of currently available erythropoietic agents to improve anemia in patients suffering from cancer. However, it is also clear from recent reports that scrutiny on the safe use of these drugs is still required.
Condensation Products of Aldehydes and Ketones with o-Aminobenzyl Alcohol and o-Hydroxybenzylamine (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCondensation Products of Aldehydes and Ketones with o-Aminobenzyl Alcohol and o-HydroxybenzylamineFrederick W. Holly and Arthur C. CopeCite this: J. Am. Chem. Soc. 1944, 66, 11, 1875–1879Publication Date (Print):November 1, 1944Publication History Published online1 May 2002Published inissue 1 November 1944https://pubs.acs.org/doi/10.1021/ja01239a022https://doi.org/10.1021/ja01239a022research-articleACS PublicationsRequest reuse permissionsArticle Views1849Altmetric-Citations289LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Incretins: a new treatment option for type 2 diabetes? (2007)

This article describes how the discovery of a protein almost 100 years ago led to a clinical treatment for type 2 diabetes. Food intake, but also stimulation of the sympathetic nervous system (for example physical exercise), stimulates the secretion of glucagon-like-peptide-1 (GLP-1), derived from the glucagon precursor proglucagon in the small intestine. GLP-1 stimulates the production and secretion of insulin, the release of somatostatin, glucose utilisation by increasing insulin sensitivity and in animal studies also beta-cell function and expansion (proliferation). It inhibits glucagon release, gastric emptying, appetite and food intake via the central nervous system and in animal experiments also apoptosis of beta-cells. Since GLP-1 has to be administered parenterally and its half-life is short, a long-acting GLP-1 receptor agonist (exenatide) and a long-acting GLP-1 analogue (liraglutide) have been developed as well as an inhibitor of DPP-IV (the enzyme that breaks down endogenous GLP-1). Clinical studies with exenatide and liraglutide as monotherapy show a significant increase in the postprandial insulin concentration as well as a smaller increase in the postprandial glucose values. Adding these drugs to standard oral glucose-lowering medication shows improvement in glucose and insulin concentrations and HbA1c compared with adding placebo. The effect of exenatide on HbA1c is the same as adding a long-acting insulin analogue (glargine), but the increase in weight after adding insulin is not seen after exenatide, where even a small decrease in weight is found. This is an important advantage, because most type 2 patients are already obese. Whether less beta-cell apoptosis and maintenance of beta-cell function occurs, as has been shown in animal studies, has to be awaited. Clinical studies with the oral DPPIV inhibitors sitagliptin and vildagliptin show promising results, but are only published as abstracts at scientific meetings.
Stress hypERactivation in the β-cell (2010)

In pancreatic β-cells, the endoplasmic reticulum (ER) is the crucial site for insulin biosynthesis, as this is where the protein-folding machinery for secretory proteins is localized. Perturbations to ER function of the β-cell, such as a high demand for insulin secretion, can lead to an imbalance in protein homeostasis and lead to ER stress. This stress can be mitigated by an adaptive, cellular response, the unfolded protein response (UPR). UPR activation is vital to the survival of β-cells, as these cells represent one of the most susceptible tissues for ER stress, due to their highly secretory function. However, in some cases, this response is not sufficient to relieve stress, leading to apoptosis and contributing to the pathogenesis of diabetes. Recent evidence shows that ER stress plays a significant role in both type 1 and type 2 diabetes. In this review, we outline the mechanisms of ER stress-mediated β-cell death and focus on the role of ER stress in various forms of diabetes, particularly a genetic form of diabetes called Wolfram syndrome.
<i>c‐Jun</i> amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation programme (2009)

Genomic amplification of c-Jun and its upstream kinases have been implicated as a mechanism of progression from well-differentiated to dedifferentiated liposarcoma. To further define the role of c-Jun in liposarcoma progression, we performed immunohistochemistry for c-Jun and its activating kinase ASK1 on a series of liposarcomas (n = 81). We correlated the results with fluorescence in situ hybridization to detect c-Jun amplification. We also derived new cell lines from dedifferentiated liposarcomas with c-Jun amplification. c-Jun protein is expressed in the majority of dedifferentiated liposarcomas (91%) and their well-differentiated components (59%), but only in the minority of pure well-differentiated liposarcomas (27%). When c-Jun is amplified in dedifferentiated liposarcoma, it is interspersed with amplified MDM2 on ring and giant marker chromosomes. MDM2 amplification is one of the earliest events in liposarcoma development, and these results suggest that c-Jun was amplified at a similar time in the evolution of the tumour. In addition, shRNA to c-Jun in c-Jun-amplified liposarcoma cells reduces cell number in vitro and inhibits tumour formation in vivo without an observable effect on the differentiation state of the liposarcoma cells. Thus, c-Jun amplification is oncogenic in liposarcomas but not always sufficient for inhibition of adipocytic differentiation.