gebhart/patrepeval huggingface dataset:
Molecular characterization of an operon required for pertussis toxin secretion. (1993)

Mutants of Bordetella pertussis which are defective in secretion of pertussis toxin were isolated and characterized. The region of the B. pertussis chromosome identified by mutagenesis as playing a role in transport of pertussis toxin was sequenced. Analysis of this region revealed eight open reading frames, seven of which predict a protein exhibiting homology with one of the VirB proteins of Agrobacterium tumefaciens, which are involved in the transport of the T-DNA molecule across bacterial and plant membranes. Thus a set of accessory proteins are most likely involved in the secretion of pertussis toxin, and these proteins appear to be members of a family of proteins involved in the secretion of macromolecules from bacteria.
HTLV-I Arthropathy and Sjögren Syndrome (1996)

Human T-cell lymphotropic virus type I (HTLV-I) was initially detected as the causative agent of adult T-cell leukemia (ATL). However, recent studies have revealed that HTLV-I may disrupt the immune system and lead to the development of rheumatoid arthritis and Sjögren syndrome. A current study in our laboratory has revealed that HTLV-I tax gene, known as the transregulatory gene, contributes not only to the induction of synovial cell hyperplasia but also the immune response, both in vivo and in vitro. In this report, the role of HTLV-I in the pathogenesis of chronic destructive arthropathy and Sjögren syndrome is discussed.
Length of Telomeric Repeats in Neuroblastoma: Correlation with Prognosis and Other Biological Characteristics (1992)

Telomeres are the physical ends of eukaryotic chromosomes. In view of reports of the reduction of telomeric repeats in human malignant tumors, we measured the lengths of telomeric repeats in 55 primary neuroblastomas. The average lengths of telomeric repeats in these tumors fell in a wide range (from 1.1 kb to more than 23 kb) relative to those in ganglioneuromas and normal peripheral mononuclear cells. The reduction of telomeric repeats was significantly correlated with advanced stages of tumor development, poor prognosis, and increased S-phase fractions in tumor cells. On the other hand, three cases of Stage IV-S tumors showed the reduction of telomeric repeats and low percentage of S-phase fractions. These Stage IV-S patients had a good prognosis with spontaneous regression of metastatic tumors.
Purification, Cloning, and Expression of a Novel, Endogenous, Calcium-sensitive, 28-kDa Phosphoprotein (1996)

In gastric parietal cells, cholinergically induced increases in intracellular free calcium concentrations have been well characterized, but little is known about the signaling events beyond the initial rise in intracellular calcium. In the present study, we report the isolation of a 28-kDa protein, which is rapidly phosphorylated in intact, enriched parietal cells in response to both the cholinergic agonist, carbachol, and the calcium ionophore, ionomycin. A combination of in situ 32P labeling and one- and two-dimensional gel electrophoresis was used to acquire sufficient quantities of protein to obtain partial amino acid sequence. Cloning of the pp28 cDNA revealed a novel protein which we have named CSPP28 based on its calcium-sensitive phosphorylation. There are three CSPP28 mRNA species (1.7, 2.2, and 3.3 kilobases) that are widely distributed throughout a variety of rabbit tissues. Recombinant CSPP28 was phosphorylated by both crude parietal cell homogenate and purified CaM kinase II in a calcium/calmodulin-dependent manner. We propose that CSPP28 may play an important and ubiquitous role in the calcium signaling pathway.
Effect of non‐ionic polymers on radioallergoimmunosorbent reactions (1972)

Abstract The effect of polyethylene glycol on the solid phase radioimmunoassay procedure for the estimation of reagins was studied. The enhanced uptake of specific anti‐IgE antibodies to either sorbent‐allergen‐IgE‐ or sorbent‐antiallergen‐allergen‐IgE‐complex in the presence of polyethylene glycol was observed.
Building castles out of mud (2008)

We introduce a new practical mechanism for remote data storage with efficient access pattern privacy and correctness. A storage client can deploy this mechanism to issue encrypted reads, writes, and inserts to a potentially curious and malicious storage service provider, without revealing information or access patterns. The provider is unable to establish any correlation between successive accesses, or even to distinguish between a read and a write. Moreover, the client is provided with strong correctness assurances for its operations -- illicit provider behavior does not go undetected. We built a first practical system -- orders of magnitude faster than existing implementations -- that can execute over several queries per second on 1Tbyte+ databases with full computational privacy and correctness.
Nanocavity absorption enhancement for two-dimensional material monolayer systems (2015)

Here we propose a strategy to enhance the light-matter interaction of two-dimensional (2D) material monolayers based on strong interference effect in planar nanocavities, and overcome the limitation between optical absorption and the atomically-thin thickness of 2D materials. By exploring the role of spacer layers with different thicknesses and refractive indices, we demonstrate that a nanocavity with an air spacer layer placed between a graphene monolayer and an aluminum reflector layer will enhance the exclusive absorption in the graphene monolayer effectively, which is particularly useful for the development of atomically-thin energy harvesting/conversion devices.
Inhibition of DNA damage repair by artificial activation of PARP with siDNA (2013)

One of the major early steps of repair is the recruitment of repair proteins at the damage site, and this is coordinated by a cascade of modifications controlled by phosphatidylinositol 3-kinase-related kinases and/or poly (ADP-ribose) polymerase (PARP). We used short interfering DNA molecules mimicking double-strand breaks (called Dbait) or single-strand breaks (called Pbait) to promote DNA-dependent protein kinase (DNA-PK) and PARP activation. Dbait bound and induced both PARP and DNA-PK activities, whereas Pbait acts only on PARP. Therefore, comparative study of the two molecules allows analysis of the respective roles of the two signaling pathways: both recruit proteins involved in single-strand break repair (PARP, XRCC1 and PCNA) and prevent their recruitment at chromosomal damage. Dbait, but not Pbait, also inhibits recruitment of proteins involved in double-strand break repair (53BP1, NBS1, RAD51 and DNA-PK). By these ways, Pbait and Dbait disorganize DNA repair, thereby sensitizing cells to various treatments. Single-strand breaks repair inhibition depends on direct trapping of the main proteins on both molecules. Double-strand breaks repair inhibition may be indirect, resulting from the phosphorylation of double-strand breaks repair proteins and chromatin targets by activated DNA-PK. The DNA repair inhibition by both molecules is confirmed by their synthetic lethality with BRCA mutations.
Ovarian tumors of the hen. (1987)

Present available information regarding ovarian tumors in hens is incomplete in most aspects, and this lack of knowledge hampers use of hens as models for study of ovarian cancer. A study of 466 hens ranging from 2 to 7 years of age and covering a period of more than 3 years has provided much needed information relative to reproductive tract neoplasia. On the basis of this study, it is apparent that hens have a high rate of ovarian tumors, but that such tumors are uncommon in hens less than 2 years of age. Adenocarcinomas with a high degree of morphologic variability are the most common ovarian tumors in hens. Hormonal imbalance does not appear to be a factor in the development of these adenocarcinomas. Steroidogenic and morphologically distinctive granulosa cell tumors originating from follicles in atrophic ovaries represent another common ovarian tumor type. Unique to the hen are oviductal adenocarcinomas. These tumors arise from the albumin-secreting glands of the oviduct, occur with relatively high frequency, and must be differentiated from ovarian adenocarcinomas.
Lithofacies classification based on multiresolution graph-based clustering using image log in South Pars gas field (2017)

One of the most important parameters in understanding static modeling of reservoir are having facies and their distribution in the reservoir zone. Since in the most of reservoirs facies distribution directly related to the permeability and porosity variation, therefore having these parameters can gain an estimate of the distribution of reservoir parameters. To determine lithofacies in wells and in reservoir there are different methods. One of the common method is to use the core drilling based on geological study. Recently with the image logs one can measure fracture distribution and it is a powerful tools for studying lithofacies as well. As a new work done one can determine a method to predict facies types and facies variations using image logs. Formation Micro Imager, FMI, log is the tool for illustrating geological markers through wells. FMI log could provide 80% coverage of well by high-resolution data. In this study, South Pars gas field is studied. First, Fullset logs and cross plot are generated, in order to formation evaluation, then the amounts petrophysical parameters such as saturation and effective porosity are estimated for different zones. Section K1, K2 and K4 are the reservoir areas and hydrocarbon contained zones are determined. After Lithofacies classification based on core – fullset log data and processing of FMI datasets. Finally, Lithofacies based on FMI log data modeled and clustered, this model gives satisfactory results when compared to core-log and core observed reservoir facies. This paper has been withdrawn from the Technical Program and will not be presented at the 87th SEG Annual Meeting.
REVIEWS (1939)

Journal Article REVIEWS Get access Das Ethos des Alien Testaments. (Beihefte zur Zeitschrift für die alttestamentliche Wissenschaft 67.) By JOHANNES HEMPEL. Pp. viii + 287. ( Töpelmann, Berlin, 1938.) H. WHEELER ROBINSON H. WHEELER ROBINSON Search for other works by this author on: Oxford Academic Google Scholar The Journal of Theological Studies, Volume os-XL, Issue 2, April 1939, Pages 174–176, https://doi.org/10.1093/jts/os-XL.2.174 Published: 01 April 1939
Standard Operating Procedures for the Clinical Management of Patients Enrolled in a Prospective Study of Inflammation and the Host Response to Thermal Injury (2007)

As part of the National Institutes of General Medical Sciences (NIGMS)-funded Inflammation and the Host Response to Injury study, participating investigators created a database, a clinical data collection protocol, and web-based case report form. To obtain high-quality clinical endpoints for correlation with genomic data, a uniform approach to patient management between centers was required. Standard operating procedures (SOPs) were generated to minimize variability and promote a uniform standard of patient care. The SOPs are necessary to enable validation of the clinical endpoints to be used for comparison with genomic and proteomic information derived from samples of blood and tissue obtained from thermally injured patients. Participating investigators identified areas of potential practice variation and developed a set of SOPs based on available data and sound clinical principles. In the absence of sufficient clinical data to identify a single management strategy, SOPs were designed to apply the best approach to management without interfering with local standards of care. The data- collection instrument, or case report form, was constructed concurrently with the SOPs. Wherever possible, the case report form was modified to collect data that might resolve controversial management issues. Modifications in management strategies that were necessary for children are delineated as needed. Data queries and site visits were conducted to audit compliance. SOPs for 10 areas of clinical care were developed. The institution of the SOPs required minor changes in clinical practice patterns and personnel training but did not require participating centers to procure new technology or alter the utilization of clinical resources significantly. The SOPs represent current management strategies applied to the study population to reduce variation in patient management. The SOPs are easily adaptable to other burn-related clinical protocols as well as to the routine daily management burn patients.
CAMPYLOBACTER JEJUNI INFECTION AND GUILLAIN-BARRé SYNDROME (2000)

目的:探讨空肠弯曲菌感染与Guillain-Barre综合征(GBS)发病的关系以及空肠弯曲菌感染和抗-GM1抗体与疾病严重程度的关系.方法:用ELISA方法检测85例GBS患者血清中的空肠弯曲菌IgG、IgM、IgA抗体及抗-GM1抗体,同时从患者的大便中培养空肠弯曲菌;根据Hughes报道的方法对病情轻重进行评分.结果:GBS患者空肠弯曲菌感染率为51.8%,抗-GM1抗体检出率为42.4%;近期空肠弯曲菌感染者抗-GM1抗体检出率(63.6%)显著高于未感染者(19.5%)(P 0.05).结论:空肠弯曲菌感染是GBS的重要诱发因素之一;血清中抗-GM1抗体的存在与近期空肠弯曲菌感染有关,但空肠弯曲菌感染及抗-GM1抗体的存在与疾病严重程度无关.
Blood Flow Remodels Growing Vasculature During Vascular Endothelial Growth Factor Gene Therapy and Determines Between Capillary Arterialization and Sprouting Angiogenesis (2005)

This study shows that (1) blood flow modulates vessel growth during VEGF gene therapy and (2) VEGF overexpression promotes growth of arteries and veins and induces capillary arterialization leading to supraphysiological blood flow in target muscles.
A noble-metal free Cu-catalyst derived from hydrotalcite for highly efficient hydrogenation of biomass-derived furfural and levulinic acid (2013)

A Cu-catalyst derived from hydrotalcite precursor was highly selective for the hydrogenation of biomass-derived furfural and levulinic acid. 90% yield of furfuryl alcohol and 51% yield of 2-methylfuran were achieved selectively in the hydrogenation of furfural. 91% yield of γ-valerolactone was achieved in the hydrogenation of levulinic acid.
Polymers Constituted by Methyl Methacrylate, Methacrylic Acid, and Methacryloyl Chloride as a Positive Electron Resist (1979)

Mixture systems of copolymer of methyl methacrylate‐methacrylic acid P(MMA‐MA) and terpolymer of methyl methacrylate‐methacrylic acid‐methacryloyl chloride P(MMA‐MA‐ClMA) have been synthesized and investigated as a positive electron resist. These resists form intermolecular acid anhydride bonds after baking, resulting in improved sensitivity and thermal stability while maintaining high resolution as compared with poly(methyl methacrylate). The polymer containing 5 mole percent (m/o) methacrylic acid (MA) and 0.5 m/o methacryloyl chloride (ClMA) has a sensitivity of at an accelerating voltage of 30 kV, a thermal stability even above 140°C. The sensitivity of the polymer containing 0.36 m/o ClMA is , which is 20 times that of PMMA.
Converging Blockchain and Machine Learning for Healthcare (2019)

The power of machine learning in understanding the patterns in data, analyzing and making decisions, has shown its importance in various sectors. Machine Learning requires reasonable amount of data to make accurate decisions. Data sharing and reliability of data is very crucial in machine learning in order to improve its accuracy. The decentralized database in Blockchain Technology emphasizes on data sharing. The consensus in Blockchain technology makes sure that data is legitimate and secured. The convergence of these two technologies can give highly accurate results in terms of machine learning with the security and reliability of Blockchain Technology. This paper gives an overview of how combining these two technologies can help in healthcare sectors.
Infrared spectra of the cluster ions H7O+3⋅H2 and H9O+4⋅H2 (1986)

Infrared spectra of hydrated hydronium ions weakly bound to an H2 molecule, specifically H7O+3 ⋅H2 and H9O+4 ⋅H2, have been observed. Mass-selected parent ions, trapped in a radio frequency ion trap, are excited by a tunable infrared laser; following absorption, the complex predissociates with loss of the H2, and the resulting fragment ions are detected. Spectra have been taken from 3000 to 4000 cm−1, with a resolution of 1.2 cm−1. They are compared to recent theoretical and experimental spectra of the hydronium ion hydrates alone. Binding an H2 molecule to these clusters should only weakly perturb their vibrations; if so, our spectra should be similar to spectra of the hydrated hydronium ions H7O+3 and H9O+4.
Striking Denervation of Neuromuscular Junctions without Lumbar Motoneuron Loss in Geriatric Mouse Muscle (2011)

Reasons for the progressive age-related loss of skeletal muscle mass and function, namely sarcopenia, are complex. Few studies describe sarcopenia in mice, although this species is the mammalian model of choice for genetic intervention and development of pharmaceutical interventions for muscle degeneration. One factor, important to sarcopenia-associated neuromuscular change, is myofibre denervation. Here we describe the morphology of the neuromuscular compartment in young (3 month) compared to geriatric (29 month) old female C57Bl/6J mice. There was no significant difference in the size or number of motoneuron cell bodies at the lumbar level (L1-L5) of the spinal cord at 3 and 29 months. However, in geriatric mice, there was a striking increase (by ∼2.5 fold) in the percentage of fully denervated neuromuscular junctions (NMJs) and associated deterioration of Schwann cells in fast extensor digitorum longus (EDL), but not in slow soleus muscles. There were also distinct changes in myofibre composition of lower limb muscles (tibialis anterior (TA) and soleus) with a shift at 29 months to a faster phenotype in fast TA muscle and to a slower phenotype in slow soleus muscle. Overall, we demonstrate complex changes at the NMJ and muscle levels in geriatric mice that occur despite the maintenance of motoneuron cell bodies in the spinal cord. The challenge is to identify which components of the neuromuscular system are primarily responsible for the marked changes within the NMJ and muscle, in order to selectively target future interventions to reduce sarcopenia.
Gadolinium complex of tris[(3-hydroxy-1-methyl- 2-oxo-1,2-didehydropyridine-4-carboxamido)ethyl]-amine: A New Class of gadolinium magnetic resonance relaxation agents (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGadolinium complex of tris[(3-hydroxy-1-methyl- 2-oxo-1,2-didehydropyridine-4-carboxamido)ethyl]-amine: A New Class of gadolinium magnetic resonance relaxation agentsJide Xu, Sonya J. Franklin, Donald W. Whisenhunt Jr., and Kenneth N. RaymondCite this: J. Am. Chem. Soc. 1995, 117, 27, 7245–7246Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/ja00132a025https://doi.org/10.1021/ja00132a025research-articleACS PublicationsRequest reuse permissionsArticle Views1105Altmetric-Citations138LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Enhanced Vascular Responses to Adrenomedullin in Mice Overexpressing Receptor-Activity–Modifying Protein 2 (2005)

Adrenomedullin (AM) levels are elevated in cardiovascular disease, but little is known of the role of specific receptor components. AM acts via the calcitonin receptor-like receptor (CLR) interacting with a receptor-activity-modifying protein (RAMP). The AM1 receptor is composed of CLR and RAMP2, and the calcitonin gene-related peptide (CGRP) receptor of CLR and RAMP1, as determined by molecular and cell-based analysis. This study examines the relevance of RAMP2 in vivo. Transgenic (TG) mice that overexpress RAMP2 in smooth muscle were generated. The role of RAMP2 in the regulation of blood pressure and in vascular function was investigated. Basal blood pressure, acute angiotensin II-raised blood pressure, and cardiovascular properties were similar in wild-type (WT) and TG mice. However, the hypotensive effect of IV AM, unlike CGRP, was enhanced in TG mice (P<0.05), whereas a negative inotropic action was excluded by left-ventricular pressure-volume analysis. In aorta relaxation studies, TG vessels responded in a more sensitive manner to AM (EC50, 8.0+/-1.5 nmol/L) than WT (EC50, 17.9+/-3.6 nmol/L). These responses were attenuated by the AM receptor antagonist, AM(22-52), such that residual responses were identical in all mice. Remaining relaxations were further inhibited by CGRP receptor antagonists, although neither affected AM responses when given alone. Mesenteric and cutaneous resistance vessels were also more sensitive to AM in TG than WT mice. Thus RAMP2 plays a key role in the sensitivity and potency of AM-induced hypotensive responses via the AM1 receptor, providing evidence that this receptor is a selective target for novel therapeutic approaches.
Crosstalk between light pipes (1976)

Using mode theory, we calculate the crosstalk between overmoded optical fibers or light pipes when one fiber is illuminated by a focused collimated beam. The presence of many modes allows the summation of crosstalk power between individual modes to be converted to an integral expression. The result is applied to two parallel, identical fibers, a hexagonal array of fibers, lossy fibers, and fibers of unequal diameter. In practice, the light pipes must be nearly identical and touching for significant crosstalk.
Chaotic mixing in electrokinetically and pressure driven micro flows (2002)

We present two micro-devices, fabricated by using MEMS technology, in which mixing of fluid and particles takes place. The systems are designed to induce folding and stretching of material lines, leading to chaotic-like mixing. In a first case, we use unsteady pressure perturbations superimposed to a mean stream, and in the second case, time-dependent dielectrophoretic forces to induce folding and stretching. The first device shows chaotic-like mixing is achieved in an efficient way, leading to rapidly homogenizing concentration fields. Folding and stretching effects inducing mixing are shown for the second system. The systems are simple in their conception and may favorably be integrated within complex bio-MEMS.
Peptide Amphiphile Nanofibers Template and Catalyze Silica Nanotube Formation (2007)

Hollow silica nanotubes with tunable dimensions have been synthesized by condensation of tetraethoxysilane (TEOS) on peptide-amphiphile nanofiber templates followed by calcination. Peptide-amphiphile nanofibers direct silica mineralization by providing nucleation sites and catalyze silica polymerization at their surface. The catalytic activities of peptide-amphiphiles containing lysine, histidine, or glutamic acid were compared and only peptide amphiphiles containing lysine or histidine were found to be good catalytic templates. Depending on the reaction conditions, and the size of the PA assembler, the nanotube wall thickness could be varied between 5 and 9 nm.