gebhart/patrepeval huggingface dataset:
Controlling and Monitoring Stem Cell Safety In Vivo in an Experimental Rodent Model (2014)

Adult stem cells have been investigated increasingly over the past years for multiple applications. Although they have a more favorable safety profile compared to pluripotent stem cells, they are still capable of self-renewal and differentiate into several cell types. We investigated the behavior of Oct4-positive (Oct4(+)) and Oct4-negative (Oct4(-) ) murine or rat bone marrow (BM)-derived stem cells in the healthy brain of syngeneic mice and rats. Engraftment of mouse and rat Oct4-positive BM-derived hypoblast-like stem cells (m/rOct4(+) BM-HypoSCs) resulted in yolk-sac tumor formation in the healthy brain which was monitored longitudinally using magnetic resonance imaging (MRI) and bioluminescence imaging (BLI). Contrast enhanced MRI confirmed the disruption of the blood brain barrier. In contrast, m/r Oct4-negative BM-derived multipotent adult progenitor cells (m/rOct4(-) BM-MAPCs) did not result in mass formation after engraftment into the brain. mOct4(+) BM-HypoSCs and mOct4(-) BM-MAPCs were transduced to express enhanced green fluorescent protein, firefly luciferase (fLuc), and herpes simplex virus-thymidine kinase to follow up suicide gene expression as a potential "safety switch" for tumor-forming stem cells by multimodal imaging. Both cell lines were eradicated efficiently in vivo by ganciclovir administration indicating successful suicide gene expression in vivo, as assessed by MRI, BLI, and histology. The use of suicide genes to prevent tumor formation is in particular of interest for therapeutic approaches where stem cells are used as vehicles to deliver therapeutic genes.
A Temperature Dependent, Single Particle, Lithium Ion Cell Model Including Electrolyte Diffusion (2014)

Low-order, explicit models of lithium ion cells are critical for real-time battery management system (BMS) applications. This paper presents a seventh-order, electrolyte enhanced single particle model (ESPM) with electrolyte diffusion and temperature dependent parameters (ESPM-T). The impedance transfer function coefficients are explicit in terms of the model parameters, simplifying the implementation of temperature dependence. The ESPM-T model is compared with a commercially available finite volume based model and results show accurate matching of pulse responses over a wide range of temperature (T) and C-rates (I). The voltage response to 30 s pulse charge–discharge current inputs is within 5% of the commercial code for 25 °C<T<50 °C at I≤12.5C and -10 °C<T<50°C at I≤1C for a graphite/nickel cobalt manganese (NCM) lithium ion cell.
B7-H3 Contributes to the Development of Pathogenic Th2 Cells in a Murine Model of Asthma (2008)

B7-H3 is a new member of the B7 family. The receptor for B7-H3 has not been identified, but it seems to be expressed on activated T cells. Initial studies have shown that B7-H3 provides a stimulatory signal to T cells. However, recent studies suggest a negative regulatory role for B7-H3 in T cell responses. Thus, the immunological function of B7-H3 is controversial and unclear. In this study, we investigated the effects of neutralizing anti-B7-H3 mAb in a mouse model of allergic asthma to determine whether B7-H3 contributes to the development of pathogenic Th2 cells and pulmonary inflammation. Administration of anti-B7-H3 mAb significantly reduced airway hyperreactivity with a concomitant decrease in eosinophils in the lung as compared with control IgG-treated mice. Treatment with anti-B7-H3 mAb also resulted in decreased production of Th2 cytokines (IL-4, IL-5, and IL-13) in the draining lymph node cells. Although blockade of B7-H3 during the induction phase abrogated the development of asthmatic responses, B7-H3 blockade during the effector phase did not inhibit asthmatic responses. These results indicated an important role for B7-H3 in the development of pathogenic Th2 cells during the induction phase in a murine model of asthma.
pH‐induced alterations in stratum corneum properties (2003)

Skin-cleansing compositions based on alkyl carboxylates (soaps) have a higher irritation potential than those based on syndet surfactants such as alkyl isethionates or alkyl ether sulphates. Contributing factors include inherent differences in the irritation potential of soaps and syndet surfactants, pH-induced changes in surfactant solution chemistry, and the direct effects of pH on the physical properties of the stratum corneum (SC). Past work has not directly addressed the effect of solution pH on the SC itself and its potential role in cleanser-induced skin irritation. In the current work, alterations to SC properties induced by buffered pH solutions and two strongly ionizable surfactants, sodium dodecyl sulphate and sodium lauryl ether sulphate, at different pH values are measured. By utilizing optical coherence tomography (OCT) and infrared (IR) spectroscopy we have directly measured physical changes in SC proteins and lipids. Our results indicate that SC swelling, which reflects alterations to SC structural proteins, is increased significantly at pH 10, compared to pH 4 and 6.5. The transition temperature (T(m)) of SC lipids is found to increase at pH 10, compared to pH 4 and 6.5, suggesting a more rigid SC lipid matrix. Surfactants cause a further increase in swelling and lipid rigidity. Some aspects of what these results mean for SC physical properties as well as their implications to potential mechanisms of surfactant-induced skin irritation are discussed.
Non-invasive diagnosis of early-stage lung cancer using high-throughput targeted DNA methylation sequencing of circulating tumor DNA (ctDNA) (2019)

<b>Rational:</b> LDCT screening can identify early-stage lung cancers yet introduces excessive false positives and it remains a great challenge to differentiate malignant tumors from benign solitary pulmonary nodules, which calls for better non-invasive diagnostic tools. <b>Methods:</b> We performed DNA methylation profiling by high throughput DNA bisulfite sequencing in tissue samples (nodule size < 3 cm in diameter) to learn methylation patterns that differentiate cancerous tumors from benign lesions. Then we filtered out methylation patterns exhibiting high background in circulating tumor DNA (ctDNA) and built an assay for plasma sample classification. <b>Results:</b> We first performed methylation profiling of 230 tissue samples to learn cancer-specific methylation patterns which achieved a sensitivity of 92.7% (88.3% - 97.1%) and a specificity of 92.8% (89.3% - 96.3%). These tissue-derived DNA methylation markers were further filtered using a training set of 66 plasma samples and 9 markers were selected to build a diagnostic prediction model. From an independent validation set of additional 66 plasma samples, this model obtained a sensitivity of 79.5% (63.5% - 90.7%) and a specificity of 85.2% (66.3% - 95.8%) for differentiating patients with malignant tumor (n = 39) from patients with benign lesions (n = 27). Additionally, when tested on gender and age matched asymptomatic normal individuals (n = 118), our model achieved a specificity of 93.2% (89.0% - 98.3%). Specifically, our assay is highly sensitive towards early-stage lung cancer, with a sensitivity of 75.0% (55.0%-90.0%) in 20 stage Ia lung cancer patients and 85.7% (57.1%-100.0%) in 7 stage Ib lung cancer patients. <b>Conclusions:</b> We have developed a novel sensitive blood based non-invasive diagnostic assay for detecting early stage lung cancer as well as differentiating lung cancers from benign pulmonary nodules.
Catalytic Steam Cracking of a Deasphalted Vacuum Residue Using a Ni/K Ultradispersed Catalyst (2017)

Catalytic steam cracking (CSC) of heavy hydrocarbons is seen as an alternative for further improvement upon conventional thermal cracking performance. In this work, upgrading of an industrial deasphalted vacuum residue via CSC was assessed in a bench-scale pilot plant resembling a visbreaking unit. The performance of a 400 ppm of Ni and 300 ppm K ultradispersed catalyst (UDC) formulation previously used for CSC of vacuum residue was evaluated for this nonasphaltene containing fraction. Reactivity experiments were conducted at temperatures within 435–445 °C and liquid hourly space velocities (LHSV) of 3–5.5 h–1 and operating pressure of 300 psig. A preliminary reactivity evaluation using isotopic water spanning temperatures between 423 and 445 °C was carried out to determine the conditions at which water splitting was occurring. Finally, lumped kinetic modeling including asphaltenes generation in the process was evaluated, and results were compared with previously reported thermal cracking experiments. Operating variables (T, LHSV) were found to have similar effects on the reactivity, as in thermal cracking for CSC of DAO. Even though water splitting was evidenced at temperatures above 430 °C, no significant improvement in the physical bulk properties of the liquid products was obtained for the catalytic experiments using the current formulation. This is attributed to the high degree of condensation reactions triggered at the range of temperatures evaluated. A global activation energy for the conversion of DAO (560 °C+) of 175 kJ/mol and a modeling error of 4.23% were determined. Asphaltenes generation was evidenced at a similar extent as that of thermal cracking from a kinetic point of view.
Purine: A bi-graph based deep learning framework (2014)

In this paper, we introduce a novel deep learning framework, termed Purine. In Purine, a deep network is expressed as a bipartite graph (bi-graph), which is composed of interconnected operators and data tensors. With the bi-graph abstraction, networks are easily solvable with event-driven task dispatcher. We then demonstrate that different parallelism schemes over GPUs and/or CPUs on single or multiple PCs can be universally implemented by graph composition. This eases researchers from coding for various parallelization schemes, and the same dispatcher can be used for solving variant graphs. Scheduled by the task dispatcher, memory transfers are fully overlapped with other computations, which greatly reduce the communication overhead and help us achieve approximate linear acceleration.
High-throughput Loss-of-Heterozygosity Study of Chromosome 3p in Lung Cancer Using Single-Nucleotide Polymorphism Markers (2006)

Loss of DNA copy number at the short arm of chromosome 3 is one of the most common genetic changes in human lung cancer, suggesting the existence of one or more tumor suppressor genes (TSG) at 3p. To identify most frequently deleted regions and candidate TSGs within these regions, a recently developed single-nucleotide polymorphism (SNP)-mass spectrometry-genotyping (SMSG) technology was applied to investigate the loss of heterozygosity (LOH) in 30 primary non-small-cell lung cancers. A total of 386 SNP markers that spanned a region of 70 Mb at 3p, from 3pter to 3p14.1, were selected for LOH analysis. The average intermarker distance in the present study is approximately 180 kb. Several frequently deleted regions, including 3p26.3, 3p25.3, 3p24.1, 3p23, and 3p21.1, were found. Several candidate TSGs within these frequently detected LOH regions have been found, including APG7L at 3p25.3, CLASP2 at 3p23, and CACNA2D3 at 3p21.1. This study also showed that SMSG technology is a very useful approach to rapidly define the minimal deleted region and to identify target TSGs in a given cancer.
An Autopsy Case of Epstein-Barr Virus–Associated Diffuse Large B-Cell Lymphoma of the Central Nervous System in an Immunocompromised Host (2017)

Lymphomas arising in the central nervous system (CNS) of immunocompromised hosts are most commonly non-Hodgkin's lymphomas and are highly associated with Epstein-Barr virus (EBV). Here we report an autopsy case of EBV-associated CNS diffuse large B-cell lymphoma (DLBCL) in a host suffering from systemic lupus erythematosus who underwent immunosuppressive therapy. After autopsy, EBV-associated CNS DLBCL as well as pulmonary mixed aspergillosis and <i>Pneumocystis jirovecii</i> pneumonia were added to the cause of clinical manifestations of complicated pneumonia and cerebral hemorrhage in this immunocompromised patient. In conclusion, complex disease processes were revealed by autopsy in this case, indicating that the clinicopathological correlations observed through autopsy can improve our understanding of disease progression and contribute to the management of similar patients in the future.
Giant linear anomalous Hall effect in the perpendicular CoFeB thin films (2014)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation T. Zhu, P. Chen, Q. H. Zhang, R. C. Yu, B. G. Liu; Giant linear anomalous Hall effect in the perpendicular CoFeB thin films. Appl. Phys. Lett. 19 May 2014; 104 (20): 202404. https://doi.org/10.1063/1.4878538 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Active "hugging" vest for deep touch pressure therapy (2016)

Many individuals with Autism Spectrum Disorder (ASD) and ADHD often seek out deep touch pressure (DTP). Weighted blankets, vests and other wearable garments have been used to provide DTP, but each suffers from significant limitations. We designed an alternative using shape memory alloy (SMA) springs that contract when heated to create a children's deep pressure vest that can constrict on command, while being simultaneously low profile and adjustable. The garment can be controlled via wireless remote, allowing wearer self-adjustment and enabling the child's parent, guardian, or occupational therapist (OT) to give a comforting "hug" potentially from anywhere in the world.
Selective staining of the cerebellar molecular layer by serum IgG in Miller-Fisher and related syndromes (1996)

During 1 year, we used immunocytochemical staining of human cerebellum to screen 1,488 serums for IgG autoantibodies to Hu and Yo antigens. Three serums had none of the classically described patterns of IgG binding but instead, selectively stained the cerebellar molecular layer. Evaluation of clinical data showed that the patients had either typical Miller Fisher syndrome (MFS) or Guillain-Barré syndrome with ophthalmoplegia. Further analysis by ELISA, assay showed that all three serums had high titers of IgG anti-GQ1b autoantibodies. IgG autoantibody staining of human cerebellum, which is used for the diagnosis of paraneoplastic disorders, may have additional specificity for other, presumably autoimmune, syndromes such as MFS. The specificity of the serum IgG autoantibody binding to the cerebella molecular layer may be related to the ataxia that often occurs in these patients.
Single-Site Catalysts for Ring-Opening Polymerization:  Synthesis of Heterotactic Poly(lactic acid) from <i>rac</i>-Lactide (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSingle-Site Catalysts for Ring-Opening Polymerization: Synthesis of Heterotactic Poly(lactic acid) from rac-LactideMing Cheng, Athula B. Attygalle, Emil B. Lobkovsky, and Geoffrey W. CoatesView Author Information Department of Chemistry and Chemical Biology Baker Laboratory, Cornell University Ithaca, New York 14853-1301 Cite this: J. Am. Chem. Soc. 1999, 121, 49, 11583–11584Publication Date (Web):November 24, 1999Publication History Received29 July 1999Published online24 November 1999Published inissue 1 December 1999https://pubs.acs.org/doi/10.1021/ja992678ohttps://doi.org/10.1021/ja992678orapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views7646Altmetric-Citations542LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Biopolymers,Ligands,Organic polymers,Plastics,Polymers Get e-Alerts
Motor torque based vehicle stability control for four-wheel-drive electric vehicle (2009)

Motor torque based active yaw moment control law is investigated in this paper, based on which vehicle stability control algorithm for four-wheel-drive electric vehicle is proposed using fuzzy logic control method. As four motors are mounted in the four wheels individually to drive the vehicle, it has great advantage to use the advanced motion control technique to enhance vehicle stability. The four driving and braking forces can be controlled independently to generate active yaw moment. However it is more complex to allocate the desired yaw moment to over-actuators. So the control law for fuzzy logic control algorithm is designed based on the dynamic analysis of vehicle instability. The electric vehicle models including motor model, dynamic battery model, tire model and vehicle dynamics model are built in MATLAB/Simulink <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">reg</sup> . Simulation performance is evaluated in the Simulink <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">reg</sup> , and the results have shown that the design control law and fuzzy logic controller can enhance the yaw stability and improve the maneuverability of the vehicle significantly.
Overcoming confounding plate effects in differential expression analyses of single-cell RNA-seq data (2016)

An increasing number of studies are using single-cell RNA-sequencing (scRNA-seq) to characterize the gene expression profiles of individual cells. One common analysis applied to scRNA-seq data involves detecting differentially expressed (DE) genes between cells in different biological groups. However, many experiments are designed such that the cells to be compared are processed in separate plates or chips, meaning that the groupings are confounded with systematic plate effects. This confounding aspect is frequently ignored in DE analyses of scRNA-seq data. In this article, we demonstrate that failing to consider plate effects in the statistical model results in loss of type I error control. A solution is proposed whereby counts are summed from all cells in each plate and the count sums for all plates are used in the DE analysis. This restores type I error control in the presence of plate effects without compromising detection power in simulated data. Summation is also robust to varying numbers and library sizes of cells on each plate. Similar results are observed in DE analyses of real data where the use of count sums instead of single-cell counts improves specificity and the ranking of relevant genes. This suggests that summation can assist in maintaining statistical rigour in DE analyses of scRNA-seq data with plate effects.
Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity (2004)

The compelling genetic and pharmacological evidence implicating melanin-concentrating hormone-1 receptor (MCH-1R) signalling in the regulation of food intake and energy expenditure has generated a great deal of interest by pharmaceutical companies for the discovery of MCH-1R antagonists, evidenced by the increased number of patents describing MCH-1R antagonists for the treatment of obesity and metabolic syndrome. The structural diversity of small molecular weight drug-like MCH-1R antagonists produced and preclinical studies showing hypophagia and weight loss with small molecular weight and peptidal antagonists in rodents is encouraging and suggests that the identification of clinical candidates will be forthcoming.
The performance of pigtailed annealed proton exchange LiNbO<sub>3</sub> modulators at cryogenic temperatures (1996)

Integrated optic modulators have been proposed for transmitting signals from electronic and electrooptic devices which must operate at 77 K and colder. In this letter, the V/spl pi/ of LiNbO/sub 3/ modulators at temperatures as cold as 10 K are measured. A /spl sim/9.25% increase over room temperature values is seen. This increase is attributed primarily to a temperature dependence in r/sub 33/. In addition, temperature-induced insertion loss changes are evaluated for two different pigtailing techniques and one is shown to be suitable for cryogenic operation.
Optimal primary coil size for wireless power telemetry to medical implants (2010)

A retinal prosthesis telemetry system is examined, and several methods are explored to optimize the size of the external primary telemetry coil to maximize the wireless delivery of power to an implanted secondary coil of constrained size. A simplified version of the Biot-Savart Law is used to give a first-pass optimal primary coil size for a small secondary coil. Numerical integration is then used to improve the optimization for larger secondary coils, and this calculation is repeated across a range of secondary coil radii. Finally, the effects of eye rotation angle are explored, with the future goal of expanding the optimization techniques to cover the predicted range of angular eye excursions.
LOCKE ON MONEY: MORE ANTEDATINGS (1975)

LOCKE ON MONEY: MORE ANTEDATINGS Get access ROLAND HALL ROLAND HALL University of York Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 22, Issue 12, December 1975, Pages 557–558, https://doi.org/10.1093/nq/22-12-557 Published: 01 December 1975
Evolution trends in hybrid broadcast broadband TV (2013)

The actual issues related to TV services distribution and providing, integration of classical broadcasting and IPTV services towards the concept of the HBB TV, as well as evolution processes in this field, are presented in this paper. The evolution processes are focused on the enhancement of the concept and architecture of the HBB TV, which were defined HBB TV 1.0 by HbbTV forum and published by ETSI in the specification TS 102 796, and subsequently in the supplements specification of HBB TV 1.5. The consortium of FP7 project “HBB-NEXT” orients it's activities to research and development in the area of new concept, architecture and new functionalities of the hybrid broadcast broadband technology. Topics like multimodal identification, multi-factor authentication, identity management, service recommendation and personalisation, as well as trust establishment, are in the scope of the “HBB-Next” FP7 project consortium research activities. The achieved project results and outputs are used for elaboration of contributions which are continuously submitted, by members of the requirements working group of HbbTV and will be used in the definition process of next specification of HbbTV version 2.0. Some aspects of this process will be also presented in the paper.