gebhart/patrepeval huggingface dataset:
10.5 A 5.9pJ/b 10Gb/s serial link with unequalized MM-CDR in 14nm tri-gate CMOS (2015)

High-speed serial links integrated in advanced CMOS are ubiquitous in modern microprocessor systems. These commodity links have fixed performance specs and therefore realize the benefit of technology scaling in area and power reduction at high data rates. To realize significant scaling benefits, these designs must overcome the challenges associated with implementing analog functions in scaled logic-optimized processes while maintaining link robustness over a wide range of channel characteristics and third party components.This work describes a 2.5-to-10 Gb/s serial link implemented in 14nm tri-gate CMOS using logic-pitch transistors exclusively. The half-rate embedded-clock transceiver architecture consists of a 3-tap current-mode (CM) TX, an RX with a CTLE, a 4-tap integrating DFE, and a phase-interpolator-based CDR. It is 60% smaller and consumes 11% less energy per bit than reported links at comparable data rates and channel losses. It also introduces a baud-rate CDR algorithm that uses the real-time extracted channel response at the DFE to optimize the sampling point, relaxes the headroom/swing tradeoff at the TX driver by using dynamic signal boosting, eliminates the process cost for a precision resistor by using tunable serpentine resistors, and includes a low-power and low-area RX squelch circuit with a digital peak detector.
Morphoregulatory Role of Thidiazuron (1992)

Somatic embryogenesis was induced in hypocotyl explants of geranium (Pelargonium x hortorum) cultured on media supplemented with various concentrations of N-phenyl-N'-1,2,3-thiadiazol-5-ylurea (thidiazuron). In less than 2 weeks, somatic embryos were observed in treatments containing levels of thidiazuron (TDZ) ranging from 0.2 to 1.0 micromolar. The use of N(6)-benzylaminopurine in combination with indole-3-acetic acid also evoked embryogenesis, but the efficiency of somatic embryo production was significantly lower than that obtained with TDZ. Hypocotyl culture for only 2 days on TDZ-supplemented medium before transfer to a basal medium was sufficient for inducing somatic embryogenesis. This distinction between the induction and expression of embryogenesis may provide an experimental system for studying the developmental biology of somatic embryogenesis. Substitution of the auxin-cytokinin requirement for the induction of somatic embryogenesis by TDZ suggests the possibility of a novel mode of its action by modulation of endogenous growth regulators.
A radial exploration approach to manufacturing yield estimation and design centering (1979)

An integrated approach to manufacturing yield estimation and design centering is presented in which linear searches along "radial" directions within the multiparameter component space are used to locate points on the boundary of the feasible region for a given nominal design and a set of component tolerances. This set of boundary points enables the volume of the feasible region, and hence the manufacturing yield, to be estimated by using a newly developed computational technique. For linear frequency-domain circuit behavior, application of the tracking-sensitivity algorithm further enhances the searching efficiency. The boundary points are also used within a practical design centering algorithm which minimizes the asymmetry of the feasible region around the nominal design. Iterative application of this process leads to a better centered design. Examples of the application of this algorithm to circuit design are given. The results indicate that the radial exploration approach to yield estimation and design centering is effective in practice, computationally cheap, and applicable to many situations in practical circuit design.
BIOCHEMISTRY OF BLOOD COAGULATION (1977)

Journal Article BIOCHEMISTRY OF BLOOD COAGULATION Get access M P ESNOUF, MA BSc DPhil M P ESNOUF, MA BSc DPhil Nuffield Department of Clinical Biochemistry, Radcliffe InfirmaryOxford Search for other works by this author on: Oxford Academic PubMed Google Scholar British Medical Bulletin, Volume 33, Issue 3, September 1977, Pages 213–218, https://doi.org/10.1093/oxfordjournals.bmb.a071438 Published: 01 September 1977
Hybrid sinusoidal-pulse charging strategy for Li-ion battery in electric vehicle application (2015)

This paper proposed a hybrid sinusoidal-pulse current charging strategy (HSPC) for Li-ion battery in electric vehicle application. Phase shifting of pulse currents generated in paralleled boost converters is employed to overcome the power limitation in the sinusoidal ripple current (SRC) charging method. Simulation and experimental results demonstrated that the charger efficiency of the hardware and energy transfer efficiency for the battery get improved by the proposed HSPC method. The flexibility for the topology integration with vehicle traction motor drivers can save the hardware cost and volume for the proposed charging strategy.
A Convenient Synthesis of Mixed-Acid Glycerophosphocholines (1987)

A convenient and non-enzymatic method for the synthesis of mixed-acid glycerophosphocholines is reported, using 1-O-acyl-2-O-benzylglycerol-3-O-(ß,ß,ß-trichloroethyl) carbonate as the starting material.
Comprehensive Gene and microRNA Expression Profiling Reveals a Role for microRNAs in Human Liver Development (2009)

Our results uncover multiple regulated miRNAs and genes throughout human liver development, and our algorithm assists in identification of novel miRNA targets with potential roles in liver development.
Antiproliferative effect of desferrioxamine on vascular smooth muscle cells in vitro and in vivo. (1994)

Vascular smooth muscle cell (VSMC) growth is a primary component of accelerated and spontaneous atherosclerosis. Previous studies have shown that iron may be involved in the control of enzymatic activities that modulate DNA synthesis in human cells. In this study the effects of the iron chelator desferrioxamine on in vitro and in vivo VSMC proliferation were tested. Rat VSMCs in culture and a rabbit model of carotid artery balloon injury were used. Desferrioxamine showed a significant inhibitory effect on [3H]thymidine incorporation in cell cultures that was antagonized by iron supplementation. Desferrioxamine also provided effective preventive myointimal VSMC proliferation as assessed by bromodeoxyuridine labeling and morphometric analysis of endoluminal stenosis. These experiments suggested that iron may be involved in the control of VSMC proliferation and that desferrioxamine may have a role in preventing VSMC growth and myointimal proliferative lesions.
Opportunistic Radio and Licensed Users Coexistence in Cellular Networks (2007)

A scenario based on an UMTS TDD opportunistic cellular system that operates over UMTS FDD licensed cellular networks is considered. Therefore we develop a simulation tool that addresses the goal of analysis and assessment of UMTS TDD opportunistic radio system in a coexistence environment with UMTS FDD primary cellular networks. The communication presents the main features of the tool, discusses and proposes metrics to evaluate the multisystem coexistence, and presents illustrative simulation results. These show that with a reasonable UMTS TDD opportunistic radio transmission power and considering realistic propagation environments, a moderate number of available frequencies allow the deployment of UMTS TDD opportunistic radio networks with small blocking probabilities
An overview of experimental and numerical results on the performance of plasma antennas arrays (2015)

Gaseous plasma antenna arrays (PAA) constitute a promising alternative to conventional metallic antennas for applications in which fast reconfigurability with respect to some property (e.g., the directivity) is desired. In this communication we give an account of the ongoing research on PAAs by presenting experimental and numerical results
Akt regulates L-type Ca2+ channel activity by modulating Cavα1 protein stability (2009)

The insulin IGF-1–PI3K–Akt signaling pathway has been suggested to improve cardiac inotropism and increase Ca2+ handling through the effects of the protein kinase Akt. However, the underlying molecular mechanisms remain largely unknown. In this study, we provide evidence for an unanticipated regulatory function of Akt controlling L-type Ca2+ channel (LTCC) protein density. The pore-forming channel subunit Cavα1 contains highly conserved PEST sequences (signals for rapid protein degradation), and in-frame deletion of these PEST sequences results in increased Cavα1 protein levels. Our findings show that Akt-dependent phosphorylation of Cavβ2, the LTCC chaperone for Cavα1, antagonizes Cavα1 protein degradation by preventing Cavα1 PEST sequence recognition, leading to increased LTCC density and the consequent modulation of Ca2+ channel function. This novel mechanism by which Akt modulates LTCC stability could profoundly influence cardiac myocyte Ca2+ entry, Ca2+ handling, and contractility.
Composite Membranes: The Permeation of Gases through Deposited Monolayers (1968)

We have measured permeabilities of deposited monolayers of stearic acid varying in thickness from 8 to 48 deposited layers. These results are compared with permeabilities of polymeric films and insoluble monolayers. The technique may have applicability in the fabrication of synthetic membranes.
Continuous Electrowetting of Non-toxic Liquid Metal for RF Applications (2014)

Continuous electrowetting (CEW) is demonstrated to be an effective actuation mechanism for reconfigurable radio frequency (RF) devices that use non-toxic liquid-metal tuning elements. Previous research has shown CEW is an efficient means of electrically inducing motion in a liquid-metal slug, but precise control of the slug's position within fluidic channels has not been demonstrated. Here, the precise positioning of liquid-metal slugs is achieved using CEW actuation in conjunction with channels designed to minimize the liquid-metal surface energy at discrete locations. This approach leverages the high surface tension of liquid metal to control its resting position with submillimeter accuracy. The CEW actuation and fluidic channel design were optimized to create reconfigurable RF devices. In addition, solutions for the reliable actuation of a gallium-based, non-toxic liquid-metal alloy (Galinstan) are presented that mitigate the tendency of the alloy to form a surface oxide layer capable of wetting to the channel walls, inhibiting motion. A reconfigurable slot antenna utilizing these techniques to achieve a 15.2% tunable frequency bandwidth is demonstrated.
Identification of an Immunodominant ABC Transporter in Methicillin-Resistant <i>Staphylococcus aureus</i> Infections (2000)

Immunoblotting sera from 26 patients with septicemia due to an epidemic strain of methicillin-resistant Staphylococcus aureus (EMRSA-15), 6 of whom died, revealed an immunodominant EMRSA-15 antigen at 61 kDa. There was a statistically significant correlate (P < 0.001) between survival and immunoglobulin G to the 61-kDa band. The antigen was identified by sequencing positive clones obtained by screening a genomic expression library of EMRSA-15 with pooled sera from patients taken after the septicemic episode. Eluted antibody reacted with the 61-kDa antigen on immunoblots. The amino terminus was obtained by searching the S. aureus NCTC 8325 and MRSA strain COL databases, and the whole protein was expressed in Escherichia coli TOP 10F'. The derived amino acid sequence showed homology with ABC transporters, with paired Walker A and Walker B motifs and 73% homology to YkpA from Bacillus subtilis. Epitope mapping of the derived amino acid sequence with sera from patients who had recovered from EMRSA-15 septicemia delineated seven epitopes. Three of these epitopes, represented by peptides 1 (KIKVYVGNYDFWYQS), 2 (TVIVVSHDRHFLYNNV), and 3 (TETFLRGFLGRMLFS), were synthesized and used to isolate human recombinant antibodies from a phage antibody display library. Recombinant antibodies against peptides 1 and 2 gave logarithmic reductions in organ colony counts, compared with control groups, in a mouse model of the infection. This study suggests the potential role of an ABC transporter as a target for immunotherapy.
Production of Composite Scaffold Containing Silk Fibroin, Chitosan, and Gelatin for 3D Cell Culture and Bone Tissue Regeneration (2017)

BACKGROUND Bone tissue engineering, a powerful tool to treat bone defects, is highly dependent on use of scaffolds. Both silk fibroin (SF) and chitosan (Cs) are biocompatible and actively studied for reconstruction of tissue engineering. Gelatin (Gel) is also widely applied in the biomedical field due to its low antigenicity and physicochemical stability. MATERIAL AND METHODS In this study, 4 different types of scaffolds were constructed - SF, SF/Cs, SF/Gel, and SF/Cs/Gel - and we compared their physical and chemical properties as well as biological characterization of these scaffolds to determine the most suitable scaffold for use in bone regeneration. First, these scaffolds were produced via chemical cross-linking method and freeze-drying technique. Next, the characterization of internal structure was studied using scanning electron microscopy and the porosity was evaluated by liquid displacement method. Then, we compared physicochemical properties such as water absorption rate and degradation property. Finally, MC3T3-E1 cells were inoculated on the scaffolds to study the biocompatibility and osteogenesis of the three-dimensional (3D) scaffolds in vitro. RESULTS The composite scaffold formed by all 3 components was the best for use in bone regeneration. CONCLUSIONS We conclude that the best scaffold among the 4 studied for MC3T3-E1 cells is our SF/Cs/Gel scaffold, suggesting a new choice for bone regeneration that can be used to treat bone defects or fractures in clinical practice.
Adsorption and reactions of tetraethoxysilane (TEOS) on clean and water-dosed titanium dioxide (110) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdsorption and reactions of tetraethoxysilane (TEOS) on clean and water-dosed titanium dioxide (110)L. Gamble, M. B. Hugenschmidt, C. T. Campbell, Teresa A. Jurgens, and J. W. Rogers Jr.Cite this: J. Am. Chem. Soc. 1993, 115, 25, 12096–12105Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/ja00078a055https://doi.org/10.1021/ja00078a055research-articleACS PublicationsRequest reuse permissionsArticle Views1011Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of transfer function from frequency response data (1974)

Abstract This article presents a method of obtaining an analytical expression for the transfer function of a system in the form of a ratio of two polynomials of the complex variable, 8, from the frequency response- data. The method alleviates the deficiencies of some of the other methods previously reported in the literature. First, it guarantees that the denominator polynomial, when factorized, would not have right-half plane poles and, second, there is no need to know the degrees of the numerator and denominator polynomials, a priori. By systematically examining the time response of the synthesized transfer function, say to a unit step function, the method guarantees that the form and the coefficient values of the transfer function which is finally arrived at do give the best fit to the frequency response data. The minimum mean square error criterion is used to judge the goodness of fit.
A New Method for Feedback on the Quality of Chest Compressions during Cardiopulmonary Resuscitation (2014)

Quality of cardiopulmonary resuscitation (CPR) improves through the use of CPR feedback devices. Most feedback devices integrate the acceleration twice to estimate compression depth. However, they use additional sensors or processing techniques to compensate for large displacement drifts caused by integration. This study introduces an accelerometer-based method that avoids integration by using spectral techniques on short duration acceleration intervals. We used a manikin placed on a hard surface, a sternal triaxial accelerometer, and a photoelectric distance sensor (gold standard). Twenty volunteers provided 60 s of continuous compressions to test various rates (80-140 min(-1)), depths (3-5 cm), and accelerometer misalignment conditions. A total of 320 records with 35312 compressions were analysed. The global root-mean-square errors in rate and depth were below 1.5 min(-1) and 2 mm for analysis intervals between 2 and 5 s. For 3 s analysis intervals the 95% levels of agreement between the method and the gold standard were within -1.64-1.67 min(-1) and -1.69-1.72 mm, respectively. Accurate feedback on chest compression rate and depth is feasible applying spectral techniques to the acceleration. The method avoids additional techniques to compensate for the integration displacement drift, improving accuracy, and simplifying current accelerometer-based devices.
Planning-integrated story graph for interactive narratives (2008)

The advances in the interactive contents enable users to have a variety of experiences on diverse devices. In particular, two main approaches have been researched to construct digital interactive contents: a) conditional branch techniques and b) planning techniques. Each approach offers its own benefits; the conditional branch techniques allow the user to create tightly-plotted interactive contents; the planning techniques reduce the author's burden to specify every possible connection between contents considering the user input. As an attempt to combine these advantages provided by each technique, this paper discusses an interactive story structure incorporating the planning technique into the conditional branch techniques. Also, we briefly describe PRISM, a framework capable of creating and playing our story structure. We expect that the author can compose well-woven stories which can respond to a wide range of user interaction.
Intravenous Immunoglobulins Are a Therapeutic Option in the Treatment of Multiple Sclerosis Relapse (2011)

Intravenous immunoglobulin did not show inferiority compared with IVMP in the treatment of an acute MS relapse evaluated clinically and radiologically. Therefore, we suggest that IVIG may be tried as a therapy in acute MS relapse, especially in case of contraindications to IVMP and plasmapheresis.
Pharmacoproteomics of 4-Phenylbutyrate-Treated IB3-1 Cystic Fibrosis Bronchial Epithelial Cells (2006)

4-Phenylbutyrate (4-PBA) is an oral butyrate derivative that has recently been approved for treatment of urea cycle disorders and is under investigation in clinical trials of cancer, hemoglobinopathies, and cystic fibrosis (CF). We hypothesized that proteome profiling of IB3-1 cystic fibrosis bronchial epithelial cells treated with 4-PBA would identify butyrate-responsive cellular chaperones, protein processing enzymes, and cell trafficking molecules associated with the amelioration of the chloride transport defect in these cells. Protein profiles were analyzed by two-dimensional gel electrophoresis and mass spectrometry. Over a pI range of 4-7 and molecular weight from 20 to 150 kDa a total of 85 differentially expressed proteins were detected. Most of the identified proteins were chaperones, catalytic enzymes, and proteins comprising structural elements, cellular defense, protein biosynthesis, trafficking activity, and ion transport. Subsets of these proteins were confirmed by immunoblot analysis. These data represent a first-draft of the pharmacoproteomics map of 4-PBA treated cystic fibrosis bronchial epithelial cells.
Zur Biogenese des Xanthocillins (1965)

The biosynthesis of the antibioticum xanthocillin (1.4-bis- [4-hydroxylphenyl] -butadien- (1.3-diisonitril- (2.3)) (I) in P. notatum Westling has been investigated. DL-Tyrosin- [2- 14 C] proved to be an excellent precursor for the 1.4-diaryl-butadien portion of I (18-25% incorporation) whereas tyrosin-[1- 14 C] is not incorporated into I. The nitrogen of the isonitril group does very probably not come from the amino group of tyrosin since the 14 C/ 15 N ratio increases from 10.2 to 61.6 when DL-tyrosin- [2- 14 C- 15 N] is incorporated into I. Acetate-1- and -[2- 14 C], formate-[ 14 C] and methionine-[ 14 CH 3 ] were tested as possible precursors for the isonitril-C-atom but in none of these cases was activity found in this carbon-atom.
Doppler ultrasound in the measurement of pulse wave velocity: agreement with the Complior method (2011)

Aortic stiffness is an independent predictor factor for cardiovascular risk. Different methods for determining pulse wave velocity (PWV) are used, among which the most common are mechanical methods such as SphygmoCor or Complior, which require specific devices and are limited by technical difficulty in obtaining measurements. Doppler guided by 2D ultrasound is a good alternative to these methods. We studied 40 patients (29 male, aged 21 to 82 years) comparing the Complior method with Doppler. Agreement of both devices was high (R = 0.91, 0.84-0.95, 95% CI). The reproducibility analysis revealed no intra-nor interobserver differences. Based on these results, we conclude that Doppler ultrasound is a reliable and reproducible alternative to other established methods for the measurement of aortic PWV.
Homogeneous Immunoassay Based on Two-Photon Excitation Fluorescence Resonance Energy Transfer (2008)

A two-photon excitable small organic molecule (abbreviated as TP-NH 2) with large two-photon absorption cross section and competitive fluorescence quantum yield was prepared, which emitted fluorescence in the visible region upon excitation at 800 nm. Using the TP-NH 2 molecule as an energy donor, a two-photon excitation fluorescence resonance energy-transfer (TPE-FRET) based homogeneous immunoassay method was proposed. The donor and the acceptor (DABS-Cl, a dark quencher) were labeled to bovine serum albumin (BSA) separately, and anti-BSA protein was determined by employing an antibody bridging assay scheme. Rabbit anti-BSA serum containing other biomolecules was intentionally used as the sample to introduce interference. A parallel assay was performed using the traditional one-photon excitation FRET model, which failed to carry out quantitative determination due to the serious background luminescence arising from those biomolecules in the sample. The TPE-FRET model showed its strong ability to overcome the problem of autofluorescence and provided satisfying analytical performance. Quite good sensitivity and wide linear range (0.05-2.5 nM) for anti-BSA protein was obtained. The results of this work suggest that TPE-FRET could be a promising technique for homogeneous assays excluding separation steps, especially in complicated biological sample matrixes.