gebhart/patrepeval huggingface dataset:
Synthesis and x-ray crystallographic characterization of an oxo-bridged bimetallic organosamarium complex, [(C5Me5)2Sm]2(.mu.-O) (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and x-ray crystallographic characterization of an oxo-bridged bimetallic organosamarium complex, [(C5Me5)2Sm]2(.mu.-O)William J. Evans, Jay W. Grate, Ira Bloom, William E. Hunter, and Jerry L. AtwoodCite this: J. Am. Chem. Soc. 1985, 107, 2, 405–409Publication Date (Print):January 1, 1985Publication History Published online1 May 2002Published inissue 1 January 1985https://pubs.acs.org/doi/10.1021/ja00288a021https://doi.org/10.1021/ja00288a021research-articleACS PublicationsRequest reuse permissionsArticle Views612Altmetric-Citations146LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Model-based synthetic view generation from a monocular video sequence (2002)

In this paper a model-based multi-view image generation system for video conferencing is presented. The system assumes that a 3-D model of the person in front of the camera is available. It extracts texture from speaking person sequence images and maps it to the static 3-D model during the videoconference session. Since only the incrementally updated texture information is transmitted during the whole session, the bandwidth requirement is very small. Based on the experimental results one can conclude that the proposed system is very promising for practical applications.
Gene structure, protein structure, and regulation of the synthesis of a sulfur-rich protein in pea seeds. (1986)

Two low molecular weight pea seed albumins (Mr approximately 6000 and approximately 4000) have been characterized by protein, cDNA, and gene sequencing. Both proteins are encoded by separate regions of the same mRNA species. The initial translation product is a preproprotein from which a signal sequence is removed co-translationally. The resultant proprotein (PA1) is then cleaved post-translationally to yield the mature form of the two albumins (PA1a and PA1b). Comparison of cDNA and protein sequences suggests that at least four different PA1 genes are expressed in the pea genome. Both PA1a and PA1b have an unusually high cysteine content (7.5 and 16.2%, respectively). Pea seeds developing under suboptimal levels of sulfur nutrient supply contain reduced levels of PA1 mRNA and accumulate greatly reduced levels of PA1a and PA1b in the mature seed. In vitro transcription studies showed that this reduced level of PA1 mRNA resulted from reduced post-transcriptional stability rather than an altered rate of transcription of the PA1 gene. In contrast, during normal seed development, the level of PA1 mRNA seems to be under transcriptional control. Sequence comparisons reveal some homology between PA1 and a number of low molecular weight proteins from seeds of a wide range of mono- and dicotyledonous plants.
Apoptosis in cerebellar granule neurons is associated with reduced interaction between CREB‐binding protein and NF‐κB (2003)

Cerebellar granule neurons undergo apoptosis when switched from medium containing depolarizing levels of potassium (high K+ medium, HK) to medium containing low K+ (LK). NF-kappaB, a ubiquitously expressed transcription factor, is involved in the survival-promoting effects of HK. However, neither the expression nor the intracellular localization of the five NF-kappaB proteins, or of IkappaB-alpha and IkappaB-beta, are altered in neurons primed to undergo apoptosis by LK, suggesting that uncommon mechanisms regulate NF-kappaB activity in granule neurons. In this study, we show that p65 interacts with the transcriptional co-activator, CREB-binding protein (CBP), in healthy neurons. The decrease in NF-kappaB transcriptional activity caused by LK treatment is accompanied by a reduction in the interaction between p65 and CBP, an alteration that is accompanied by hyperphosporylation of CBP. LK-induced CBP hyperphosphorylation can be mimicked by inhibitors of protein phosphatase (PP) 2A and PP2A-like phosphatases such as okadaic acid and cantharidin, which also causes a reduction in p65-CBP association. In addition, treatment with these inhibitors induces cell death. Treatment with high concentrations of the broad-spectrum kinase inhibitor staurosporine prevents LK-mediated CBP hyperphosphorylation and inhibits cell death. In vitro kinase assays using glutathione-S-transferase (GST)-CBP fusion proteins map the LK-regulated site of phosphorylation to a region spanning residues 1662-1840 of CBP. Our results are consistent with possibility that LK-induced apoptosis is triggered by CBP hyperphosphorylation, an alteration that causes the dissociation of CBP and NF-kappaB.
Synthesis of Nanocrystalline Nickel-Zinc Ferrites via a Microemulsion Route (2004)

Nanostructured NiZn-ferrites were synthesized using a low-temperature co-precipitation method within the reverse micelles of ternary CTAB/1-hexanol/water microemulsions. The influence of pH on the precipitation reaction was investigated. It was found that a higher pH resulted in more crystalline particles. Subsequent oxidation of the ferrous ions precipitate, which leads to the formation of spinel ferrites, is discussed. Diffraction-lines broadening and specific surface area measurements yielded an average particle size of ~ 3 nm. The saturation magnetization of the samples was 20 times smaller than for traditionally synthesized NiZn-ferrites, while the coercivities were 10 - 100 times larger than bulk NiZn-ferrites, which is consistent with the nanocrystalline nature of the synthesized magnetic material. TEM investigations were used to reveal the agglomerated nature of the synthesized samples, which is the reason why the samples do not show superparamagnetic behaviour.
Future transport network architectures (1999)

The architecture of today's long distance transmission networks, which we call the baseline architecture, is a complex and multilayered hierarchy of TDM circuits. One premise of the baseline architecture is that restoration from network failures is provided mostly by SONET/SDH rings. This article presents an alternative architecture that uses ATM and optical layer cross-connect technology for TDM services. Using a sophisticated set of network design tools developed at AT&T Labs-Research, we show that the alternative architecture offers dramatic capital savings and improved network efficiency over the baseline architecture. Most of this savings can be attributed to use of OLXC mesh network restoration, which makes more efficient use of capacity than SONET/SDH rings, and use of ATM switching for transport of TDM circuits, which consolidates the numerous TDM equipment layers inherent to the baseline architecture. In addition, motivated by the rapid growth of IP services, we analyze in the alternative architecture whether to provide restoration for IP services in the IP layer itself, by rerouting packets over precalculated restoration paths with MPLS, or to alternatively provide restoration of failed IP layer links in the OLXC layer. One potential advantage of IP layer restoration is that network operators may choose to only restore a fraction of the services, in particular the "priority" services, affected by a network failure. This article gives some methodology of how to determine this fraction at which IP layer restoration is cost-competitive with OLXC restoration.
YAP/TAZ as therapeutic targets in cancer (2016)

The biology and regulation of YAP and TAZ, two closely related transcriptional regulators, are receiving increasing attention owing to their fundamental roles in organ growth, tissue repair and cancer. In particular, the widespread activation of YAP/TAZ in carcinomas, and the crucial role of YAP/TAZ activation for many 'hallmarks' of cancer are indicating YAP/TAZ as prime targets for designing anti-cancer drugs. Here, we start from the known modalities to regulate YAP/TAZ to highlight possible routes of therapeutic intervention.
Limited junctional diversity in kappa light chains. Junctional sequences from CD43+B220+ early B cell progenitors resemble those from peripheral B cells. (1994)

Among all adult T and B cell Ag receptor chains, only Ig light chains lack N regions. It is thought that this is due to the fact that light chain genes rearrange after heavy chain genes, and that terminal deoxynucleotidyl transferase, the enzyme that adds N regions, is not longer expressed at that stage. However, this concept has been challenged recently by the demonstration that 3 to 10% of B cell precursors (CD43+B220+) appear to rearrange their light chains at approximately the same time as they undergo VH-->DJ rearrangements. To examine N region addition in B cell precursors undergoing early kappa-chain rearrangement, we PCR amplified rearranged V kappa 21 genes from the CD43+B220+ bone marrow cells and compared them to sequences obtained from whole bone marrow and spleen. Unexpectedly, all three populations showed approximately 10% N region containing junctions, most consisting of only one N nucleotide. Thus, even the B cell precursors that rearrange light chains at this early stage of development lack much N region diversity. Twelve percent of the sequences unambiguously contained P regions, which were from 1 to 5 nucleotides in length. All but 2 of the 41 productive rearrangements had the commonly observed CDR3 length of nine amino acids. Many (71%) of the sequences were out of frame. CDR3 length was very restricted in nonproductive rearrangements too, and deletion of nucleotides from V kappa and J kappa gene segments was limited. Thus, even at the level of nonproductive rearrangements, junctional diversity is minimal for kappa-chains.
Frequency analysis of atrial fibrillation (2002)

Atrial fibrillation (AF) is a common arrhythmia which can have serious clinical consequences. Different characteristics of AF may be more amenable to treatment, but it is not easy to assess the characteristics of the atrial rhythm from ECG recordings since the atrial complexes are small relative to the ventricular complexes. AF is usually seen on the ECG as apparently irregular deviations of the baseline. Our aim was to develop a technique which would allow researchers to retrieve information about the atrial rhythm non-invasively from body-surface ECGs and to assess the stability of the atrial rhythm. We recorded 300 s of simultaneous 12-lead ECGs at 500 Hz directly to a computer from six patients with AF for subsequent analysis. For stability analysis, we split the 300 s recordings into two sections of 150 s each. These were then subdivided into sections of approximately 10 s, and principal component analysis was performed on each 12-lead section, generating 12 orthogonal data components. A frequency analysis of each component was carried out using a fast Fourier transform algorithm and the average spectrum calculated for each 150 s section. From this the dominant AF frequency was identified from the peak in the spectrum between 5 and 10 Hz. The atrial waveform was most commonly observed in principal components 6, 7 and 8 with mean (SD) frequency 6.8 Hz (0.9 Hz) and range 5.9 Hz to 8.2 Hz across the subjects. The difference between the paired 150 s sections was 0.3 Hz (0.3 Hz), showing that the dominant atrial frequency could be identified consistently and that there was little short term variability.
Effects of central and terminal groups on nematic mesophase stability (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of central and terminal groups on nematic mesophase stabilityMichael J. S. Dewar and Ronald S. GoldbergCite this: J. Org. Chem. 1970, 35, 8, 2711–2715Publication Date (Print):August 1, 1970Publication History Published online1 May 2002Published inissue 1 August 1970https://pubs.acs.org/doi/10.1021/jo00833a051https://doi.org/10.1021/jo00833a051research-articleACS PublicationsRequest reuse permissionsArticle Views218Altmetric-Citations111LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Frac Hits Reveal Well Spacing May be Too Tight, Completion Volumes Too Large (2017)

Thanks to the advent of high-speed drilling in the US shale sector, the effects of so-called frac hits on production and well economics is becoming more important than ever. It means the clock is running for shale producers to figure out how to mitigate the implications of this well-to-well interference issue before they drill too many wells too close together. Multiple perspectives on the topic were presented at this year’s Unconventional Resources Technology Conference in Austin, Texas. Included among them was a technical paper authored by engineers at Shell that used a simple capital expenditure formula to illustrate the financial risks involved with getting the spacing question wrong. According to the paper’s authors, if a shale producer has an inventory of 2,000 640-acre drilling sections, and each new well costs $5 million, then adding just a single unneeded well to each section would cost the operator $10 billion. In a separate paper also delivered at the conference, Schlumberger highlighted the other downside to suboptimal spacing: poorer than expected production. The company analyzed IHS data from 300 horizontal wells in the Avalon Shale of the Delaware Basin and found that child wells (the youngest wells on a pad site) were almost 30% less productive compared with parent wells. “[Operators] see that the child well does not produce as much as the parent wells—or they see that when the child well is drilled, there is a negative impact on the parent well,” explained Foluke Ajisafe, a production and stimulation engineer at Schlumberger who led the study. The driving factors she cited were how production over time creates stress rotation and leads to pressure depletion zones, known as pressure sinks. The paper describes two types of frac hits: one is a child well fracture that grows within a pressure sink and moves toward the parent well. The other involves a “stress vortex” that “can channel a fracture” as stress orientations change and align.
Diurnal Variation in Mental Performance: A Study of Three-shift Workers (1955)

A great deal of research has been done on the diurnal variations in different forms of animal and human activity. The first diurnal variation to be observed was the one in body temperature, and it is the one most widely recognized today. Similar diurnal variations have been observed in a series of other physical processes. Extensive surveys of the literature have been given by Holmgren (1936), Jores
Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast. (1994)

A 160-kDa plasma membrane protein of the yeast Saccharomyces cerevisiae was overexpressed by mutating the PDR1 or the PDR3 transcription factor gene. The protein is the membrane-bound ATP binding cassette transporter PDR5 (Balzi, E., Wang, M., Leterme, S., Van Dyck, L., and Goffeau, A. (1994) J. Biol. Chem. 269, 2206-2214). PDR5 was solubilized with n-dodecyl-beta-D-malto-side and separated from the PMA1 plasma membrane H(+)-ATPase by glycerol gradient centrifugation. The PDR5 protein hydrolyzes nucleoside diphosphates and triphosphates. This activity is sensitive to low concentrations of vanadate, of oligomycin, and of a variety of hydrophobic compounds. Many of these properties liken PDR5 to the purified mammalian P-glycoprotein responsible for multidrug resistance.
Reconfigurable signal processing in wireless terminals [mobile applications] (2003)

In this paper, we show the necessity of reconfigurable hardware for data and signal processing in wireless mobile terminals. We first identify the key processing power requirements for realizing a third generation wireless mobile terminal with multi-link and multistandard capabilities. This is done on the basis of two real-world applications: a flexible mobile rake receiver for UMTS/W-CDMA and an OFDM decoder for high-speed wireless LAN protocols. We present a software-defined concept and a system implementation for the signal processing in these applications. The system is based on a DSP for control-flow oriented tasks, dedicated hardware for predefined data-flow oriented tasks and reconfigurable hardware for software-defined data-flow oriented tasks. A new coarse-grained approach is used to implement the reconfigurable hardware, which is in the form of an array of processing elements and also contains resource management mechanisms. The features and programming concepts of the reconfigurable hardware are emphasized further in the text.
CD14, CD16 and HLA‐DR reliably identifies human monocytes and their subsets in the context of pathologically reduced HLA‐DR expression by CD14<sup>hi</sup>/CD16<sup>neg</sup> monocytes: Expansion of CD14<sup>hi</sup>/CD16<sup>pos</sup> and contraction of CD14<sup>lo</sup>/CD16<sup>pos</sup> monocytes in acute liver failure (2012)

Changes in monocytes and their subsets (CD14(hi)/CD16(neg), CD14(hi)/CD16(pos) and CD14(lo)/CD16(pos)) have been described in several diseases. The combination of CD14, CD16 and HLA-DR has been suggested to discriminate monocytes from the CD16(pos) /HLA-DR(neg) NK-cells and neutrophils but no data exist whether this strategy can be used in situations when monocyte HLA-DR expression is pathologically reduced. Monocytes and their subsets were concurrently identified through negative (exclusion of CD66b(pos) neutrophils, CD56(pos) NKcells, CD19(pos) B-cells, and CD3(pos) T-cells) and positive gating (inclusion of monocytes by expression of CD14, CD16, and HLA-DR) strategies on 30 occasions [9 healthy controls (HC) and 21 patients with conditions associated with low monocyte HLA-DR expression]. Bland-Altman and Passing and Bablok regression statistics did not demonstrate any significant measurement bias between the two strategies of monocyte identification. Monocyte subset phenotype was then compared in 18 HC and 41 patients with acute liver failure (ALF). Compared with HC, in ALF, the percentage of CD14(hi)/CD16(pos) monocytes was higher (7% vs 4%) whilst the percentage of CD14(lo)/CD16(pos) was lower (1.9% vs. 7%) (P ≤ 0.001); HLA-DR and CD86 MFIs on all monocyte subsets were lower, whilst CCR5, CD64, and CD11b MFIs were higher (P < 0.05). The relative expression by monocyte subsets of HLA-DR, CCR2, CCR5, CX3CR1, and CD11a was similar in ALF patients and HCs. Repeat analysis of an identical antibody-fluorochrome "backbone" targeting HLA-DR, CD14, and CD16 was assessed in 189 samples across 5 different experiments. There was excellent agreement in the results obtained using the positive gating strategy (interclass correlation coefficients > 0.8). Monocytes and their subsets can be reliably identified using an antibody-fluorochrome "backbone" of HLA-DR, CD14, and CD16. CD16(pos) monocytes continue to constitutively express HLA-DR even in conditions where HLA-DR is pathologically reduced on CD14(hi)/CD16(neg) monocytes. Understanding the changes in monocyte pheontype in ALF and similar clinico-pathological diseases may allow the development of novel biomarkers or therapeutic strategies.
Guidelines for designing simulation building blocks (2003)

Instinctively, it seems better to support decision making by simulation studies carried out with domain specific simulation building blocks, than by simulation studies that start without the knowledge captured in these building blocks. However, only a limited number of project examples using simulation building blocks exist, which showed improved results as a result of the use of building blocks. We identified a number of requirements to overcome the problems in complex simulation studies. We believe that these requirements can be met by using building blocks and by carrying out the simulation studies in a predefined way. First of all a good building block architecture should be developed that supports the complexities in simulation studies. In this paper we will describe a design approach that in our point of view results in a usable set of building blocks. A proof of concept of the design approach and the architecture are given using a case for passenger modeling at airports.
Rifaximin for the treatment of hepatic encephalopathy (2008)

While no randomized, placebo-controlled studies have assessed the efficacy and long-term safety outcomes of rifaximin in the treatment of HE, rifaximin has demonstrated better efficacy and safety profiles compared with lactulose and neomycin. Future studies should assess HE outcomes with more consistent indexes and measurements and should compare the efficacy and safety of rifaximin with those of metronidazole.
Privacy-preserving blockchain-based electric vehicle charging with dynamic tariff decisions (2017)

Electric vehicles are gaining widespread adoption and are a key component in the establishment of the smart grid. Beside the increasing number of electric vehicles, a dense and widespread charging infrastructure will be required. This offers the opportunity for a broad range of different energy providers and charging station operators, both of which can offer energy at different prices depending on demand and supply. While customers benefit from a liberalized market and a wide selection of tariff options, such dynamic pricing use cases are subject to privacy issues and allow to detect the customer’s position and to track vehicles for, e.g., targeted advertisements. In this paper we present a reliable, automated and privacy-preserving selection of charging stations based on pricing and the distance to the electric vehicle. The protocol builds on a blockchain where electric vehicles signal their demand and charging stations send bids similar to an auction. The electric vehicle owner then decides on a particular charging station based on the supply-side offers it receives. This paper shows that the use of blockchains increases the reliability and the transparency of this approach while preserving the privacy of the electric vehicle owners.