gebhart/patrepeval huggingface dataset:
Fully Automated Islet Cell Counter (ICC) for the Assessment of Islet Mass, Purity, and Size Distribution by Digital Image Analysis (2016)

For isolated pancreatic islet cell preparations, it is important to be able to reliably assess their mass and quality, and for clinical applications, it is part of the regulatory requirement. Accurate assessment, however, is difficult because islets are spheroid-like cell aggregates of different sizes (<50 to 500 μm) resulting in possible thousandfold differences between the mass contribution of individual particles. The current standard manual counting method that uses size-based group classification is known to be error prone and operator dependent. Digital image analysis (DIA)-based methods can provide less subjective, more reproducible, and better-documented islet cell mass (IEQ) estimates; however, so far, none has become widely accepted or used. Here we present results obtained using a compact, self-contained islet cell counter (ICC3) that includes both the hardware and software needed for automated islet counting and requires minimal operator training and input; hence, it can be easily adapted at any center and could provide a convenient standardized cGMP-compliant IEQ assessment. Using cross-validated sample counting, we found that for most human islet cell preparations, ICC3 provides islet mass (IEQ) estimates that correlate well with those obtained by trained operators using the current manual SOP method ( r<sup>2</sup> = 0.78, slope = 1.02). Variability and reproducibility are also improved compared to the manual method, and most of the remaining variability (CV = 8.9%) results from the rearrangement of the islet particles due to movement of the sample between counts. Characterization of the size distribution is also important, and the present digitally collected data allow more detailed analysis and coverage of a wider size range. We found again that for human islet cell preparations, a Weibull distribution function provides good description of the particle size.
Recent developments on magnetic-coupled multivibrators (1960)

In a static d-c to a-c converter employing a saturating transformer with rectangular-hysteresis-loop core material in conjunction with two switching transistors (magnetic-coupled multivibrators), the oscillation frequency is linearly proportional to the d-c supply voltage. This fact is significant with regard to telemetering-transducer applications. However, the linear relation between d-c input voltage and frequency of the square-wave output voltage is quite unfavorable in those cases, e.g., design of test circuits for magnetic amplifiers, where it is necessary to vary the oscillation frequency of the magnetic-coupled multivibrator independently, without changing magnitude of the supply voltage.
Metal Alkoxides as Additives for Ruthenium(II)-Catalyzed Living Radical Polymerization (2000)

Effects of additives (metal alkoxides and halides) were investigated in the RuCl2(PPh3)3-catalyzed living radical polymerization of methyl methacrylate (MMA) in toluene at 80 °C. While the MMA polymerization with the RuCl2(PPh3)3/CCl4 system (CCl4: initiator) is very slow and produces polymers with broad molecular weight distributions (MWDs), addition of metal alkoxides, such as Al(Oi-Pr)3, Ti(Oi-Pr)4, and Sn(Oi-Pr)4, accelerated the polymerization to produce polymers with controlled molecular weights and narrow MWDs. Metal chlorides such as SnCl4 and TiCl4 were not effective additives. According to NMR and cyclic voltammetric analyses, Al(Oi-Pr)3 does not interact with monomer or the polymer termini (∼∼∼C−Cl and ∼∼∼C• radicals) but interacts with the ruthenium complex, or more likely, its higher oxidation state Ru(III) species.
Soluble poly(<i>para</i>‐phenylene)s, 3. Variation of the length and the density of the solubilizing side chains (1990)

Abstract The synthesis of a variety of alkyl‐chain‐substituted poly( para ‐phenylene) (PPP) derivatives, including those with systematically decreased density of side chains, is described, using for their preparation the Pd‐catalyzed polymerization method recently developed in Mainz (Mainz route to PPP's). The degrees of polymerization achieved range between 30 and 50, allowing the synthesis of structurally well‐defined and soluble PPP's with more than hundred 1,4‐phenylene rings attached to each other.
<title>Motion-compensated scan conversion of interlaced video sequences</title> (1996)

When an interlaced image sequence is viewed at the rate of sixty frames per second, the human visual system interpolates the data so that the missing fields are not noticeable. However, if frames are viewed individually, interlacing artifacts are quite prominent. This paper addresses the problem of deinterlacing image sequences for the purposes of analyzing video stills and generating high-resolution hardcopy of individual frames. Multiple interlaced frames are temporally integrated to estimate a single progressively-scanned still image, with motion compensation used between frames. A video observation model is defined which incorporates temporal information via estimated interframe motion vectors. The resulting ill- posed inverse problem is regularized through Bayesian maximum a posteriori (MAP) estimation, utilizing a discontinuity-preserving prior model for the spatial data. Progressively- scanned estimates computed from interlaced image sequences are shown at several spatial interpolation factors, since the multiframe Bayesian scan conversion algorithm is capable of simultaneously deinterlacing the data and enhancing spatial resolution. Problems encountered in the estimation of motion vectors from interlaced frames are addressed.
Improving Activities of Daily Living Performance in an Adult With Ataxia (2000)

Case Report| Online January 01 2000 Improving Activities of Daily Living Performance in an Adult With Ataxia Glen Gillen Glen Gillen Glen Gillen, MPA, OTR, BCN, is Clinical Instructor of Occupational Therapy, College of Physicians and Surgeons at Columbia University, New York, New York 10032 Search for other works by this author on: This Site PubMed Google Scholar Author & Article Information Online ISSN: 1943-7676 Print ISSN: 0272-9490 Copyright © 2000 by the American Occupational Therapy Association, Inc.2000 The American Journal of Occupational Therapy, 2000, Vol. 54(1), 89–96. https://doi.org/10.5014/ajot.54.1.89 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Glen Gillen; Improving Activities of Daily Living Performance in an Adult With Ataxia. Am J Occup Ther January/February 2000, Vol. 54(1), 89–96. doi: https://doi.org/10.5014/ajot.54.1.89 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe American Journal of Occupational Therapy Search Advanced Search Keywords: adult, ataxia, movement disorders, multiple sclerosis This content is only available via PDF. Copyright © 2000 by the American Occupational Therapy Association, Inc.2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Polyimide/SU-8 catheter-tip MEMS gauge pressure sensor (2012)

This paper describes the development of a polyimide/SU-8 catheter-tip MEMS gauge pressure sensor. Finite element analysis was used to investigate critical parameters, impacting on the device design and sensing characteristics. The sensing element of the device was fabricated by polyimide-based micromachining on a flexible membrane, using embedded thin-film metallic wires as piezoresistive elements. A chamber containing this flexible membrane was sealed using an adapted SU-8 bonding technique. The device was evaluated experimentally and its overall performance compared with a commercial silicon-based pressure sensor. Furthermore, the device use was demonstrated by measuring blood pressure and heart rate in vivo.
The cAMP response element in the rat thyrotropin receptor promoter. Regulation by each decanucleotide of a flanking tandem repeat uses different, additive, and novel mechanisms. (1993)

A decanucleotide tandem repeat (TR) sequence, between -162 and -140 base pairs (bp) of the minimal thyrotropin receptor promoter, decreases gene expression by repressing constitutive enhancer activity of its cAMP response element (CRE). Each decanucleotide acts additively. CRE-binding proteins and liver or thyroid nuclear extracts footprint a region including the CRE and the 3' decanucleotide, -148 to -124 bp; nuclear proteins interacting with the 3' decanucleotide protect a smaller region -148 to -135 bp. Separate groups of nuclear proteins interact with the CRE and the 3' decanucleotide; mutations of the CRE affect protein interactions with the 3' decanucleotide and the converse. Nuclear proteins bind to single- or double-stranded 3' decanucleotide DNA; those interacting with the CRE bind only double-stranded DNA. The repressor action of the 5' decanucleotide is associated with an interaction between the coding strand and a single-stranded binding protein in liver and thyroid nuclear extracts. The 5' decanucleotide is in a CT-rich region with S1 nuclease hypersensitivity, near perfect mirror images, and direct repeats. The data therefore indicate that each TR decanucleotide modulates CRE constitutive enhancer activity by different but additive mechanisms, competition versus interaction with a single-stranded binding protein, and each interacts with different nuclear proteins that are not thyroid-specific. The same region in the human thyrotropin receptor represses CRE constitutive enhancer activity by the same mechanisms, despite a nonidentical sequence and no overt TR.
MEMS technology at NASA's Jet Propulsion Laboratory (2000)

The MEMS Technology Group is part of the Microdevices Laboratory (MDL) at the Jet Propulsion Laboratory (JPL). The group pursues the development of a wide range of advanced MEMS technologies that are primarily applicable to NASA's robotic as well as manned exploration missions. Thus these technologies are ideally suited for the demanding requirements of space missions namely, low mass, low power consumption and high reliability, without significant loss of capability. End-to-end development of these technologies is conducted at the MDL, a 38,000 sq. ft. facility with approximately 5500 sq. ft. each of cleanroom (class 10 - 100,000) and characterization laboratory space. MDL facilities include computer design and simulation tools, optical and electron-beam lithography, thin film deposition equipment, dry and wet etching facilities including Deep Reactive Ion Etching, device assembly and testing facilities. Following the fabrication of the device prototypes, reliability testing of these devices is conducted at the state-of-the-art Failure Analysis Laboratory at JPL.
Factory management and transport automation (2004)

This paper presents a global solution developed for integrating the warehouses transportation system based on a fleet of automated industrial forklifts in the factory management. Each industrial forklift has been completely automated using external and internal sensors. An ERP system, as information system, has been installed in order to handle the whole factory management process. A SCADA application has also been implemented for monitoring the industrial vehicles in the plant. It also acts as an interface between the ERP and the process itself. Finally, three vehicle transportation modes have been developed and validated in the system: teleoperation, path-tracking and line tracking.
Development and disability (2002)

Aims: To investigate the physical and neurodevelopmental wellbeing of ICSI conceived 5 year olds, compared with naturally conceived controls.
Problems in human-machine interaction and communication (1997)

The synthesis of two novel radiolabelled estrogen derivatives, [125I](E)-3-methoxy-17alpha-iodovinylestra-1,3,5(10),6-tetraen-17beta-ol (E[125I]IVDE) and [125I](Z)-3-methoxy-17alpha-iodovinylestra-1,3,5(10),6-tetraen-17beta-ol (Z[125I]IVDE), was carried out aiming to study the influence of the introduction of a C6-C7 double bond on the biological properties of the estradiol molecule. 3-Methoxyestra-1,3,5(10),6-tetraen-17-one was synthesised starting from a suitably protected estrone and subsequently converted into the 17alpha-ethynyl derivative. The radioiodinated derivatives were stereoselectively formed by radioiododestannylation of the corresponding tributylstannyl precursors. The biodistribution of the novel [125I]iodovinylestradiol derivatives was evaluated in immature female mice. Biological data indicated that the Z-isomer, owing to its higher in vivo uptake by the target tissue, has the preferable configuration for further development of similar compounds for estrogen receptor detection.
Central Inertial Guidance Test Facility (CIGTF) Testing of a Depolarized Fiber Optic Gyro Inertial Sensor Assembly (1995)

Fiber Optic Gyroscopes (FOG’s) have
progressed to a state where they are now being used in a
variety of missile and aircraft attitude reference systems.
The majority of these systems utilize polarization
preserving fiber in the ring. This paper presents the
design and test results for an innovative single axis FOG
which uses commercially available commuuication fiber
for the rate sensing element. Thorough testing of a
single axis unit at the Central Inertial Guidance Test
Facility (CIGTF) at Holloman Aii Force Base, New
Mexico, U.S.A. followed by Smiths Industries testing of a
triad of gyros integrated in an Inertial Sensor Assembly
(ISA) has demonstrated performauce superior to the 1
degree per hour design requirement. Testing consisted of
static and dynamic baseline tests, input axis alignment
tests, static and dynamic temperature and magnetic field
testing. This paper presents an overview of the FOG
design and a discussion of the test results.
Stereoselective Ring-Opening Polymerization of <i>meso</i>-Lactide:  Synthesis of Syndiotactic Poly(lactic acid) (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTStereoselective Ring-Opening Polymerization of meso-Lactide: Synthesis of Syndiotactic Poly(lactic acid)Tina M. Ovitt and Geoffrey W. CoatesView Author Information Department of Chemistry and Chemical Biology Baker Laboratory, Cornell University Ithaca, New York 14853 Cite this: J. Am. Chem. Soc. 1999, 121, 16, 4072–4073Publication Date (Web):April 7, 1999Publication History Received11 January 1999Published online7 April 1999Published inissue 1 April 1999https://pubs.acs.org/doi/10.1021/ja990088khttps://doi.org/10.1021/ja990088krapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views6164Altmetric-Citations455LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Monomers,Plastics,Polymerization,Polymers,Ring-opening polymerization Get e-Alerts
Results from the 2012 Quail Action Plan Landowner Survey (2012)

A survey was conducted in the winter of 2012 to determine the current practices and preferences of New Jersey landowners. Landowners were chosen from three southern counties that remain primarily rural, agricultural areas. Five hundred eighty-one mail questionnaire surveys were sent to landowners that received a Farmer Deer Shotgun Permit. Completed surveys were returned from 219 respondents for an adjusted response rate of 37.7%. The average parcel size was 103 acres. Landowners had been farming/managing their land for an average of 24 years and 82% said that they had their primary residence on their land parcel. Sixty-six percent of these parcels contained hardwood forests, 63% contained row crops, 49% had pasture/hay, 47% contained at least some wetlands and 22% contained pine forests. Sixty-five percent of landowners indicated some level of interest in managing for quail on their property and only 13% indicated low or no interest in managing for quail. Seventy-two percent of landowners said they actively manage for wildlife on their property. The most common type of wildlife management was food plots (85%), followed by 66% for field borders and hedgerows, 17% for pine thinning, livestock fencing and fallow cropping, 15% for rotational disking and 5% for prescribed burning. Landowners considered 42% of their land cover for wildlife. Only 16% of landowners indicated that they received financial assistance through government programs. Fifty-nine percent of landowners said they were interested in providing habitat for quail on their land. However, only 20% of landowners indicated that they were willing to convert some of their land into quail habitat; an additional 39% said maybe/unsure and 41% said they would not convert their land into quail habitat.
Troponin I Phosphorylation in the Normal and Failing Adult Human Heart (1997)

This phosphorylation difference could underlie the reported greater myofibrillar calcium sensitivity of failing myocardium. The functional consequence of this difference may be an adaptive or maladaptive response to the lower and longer calcium concentration transient of the failing heart, eg, enhancing force development or producing ventricular diastolic dysfunction.
Chaotic dynamics. an introduction (1990)

"Interest in chaotic dynamics has grown explosively in recent years. Applications to practically every scientific field have had far-reaching impact. As in the first edition, the authors present all the main features of chaotic dynamics using the damped, driven pendulum as the primary model. A special feature is the inclusion of both analytic and computer exercises with which the reader may expand upon the many numerical simulations included in the book. This allows learning through participation, without the extensive scientific background demanded by more advanced books." "This second edition includes additional material on the analysis and characterization of chaotic data, and applications of chaos. Experimental data from a chaotic pendulum are analyzed using methods of nonlinear time series analysis. With the help of new computer programs provided in the book (and also available from one of the authors on an optional diskette), readers and students can learn about these methods and use them to characterize their own data. The second edition also explains methods for short-term prediction and control. Spatio-temporal chaos is now introduced with examples from fluid dynamics, crystal growth, and other areas. The number of references has more than doubled; solutions are included to selected exercises." "This new edition of Chaotic dynamics can be used as a text for a unit on chaos for physics and engineering students at the second- and third-year level. Such a unit would fit very well into modern physics and classical mechanics courses."--BOOK JACKET.
Syntheses of antibacterial 2,4-diamino-5-benzylpyrimidines. Ormetoprim and trimethoprim (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses of antibacterial 2,4-diamino-5-benzylpyrimidines. Ormetoprim and trimethoprimPercy S. Manchand, Perry Rosen, Peter S. Belica, Gloria V. Oliva, Agostino V. Perrotta, and Harry S. WongCite this: J. Org. Chem. 1992, 57, 13, 3531–3535Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/jo00039a006https://doi.org/10.1021/jo00039a006research-articleACS PublicationsRequest reuse permissionsArticle Views538Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Determination of Bathymetry Using Marine Radar Images of Waves (2002)

This paper illustrates a method of calculating bathymetric maps of shallow water areas (<20m depth) using an analysis of wave properties determined from an analysis of marine radar image sequences of waves. Water depths determined using this corrected for tidal variation in water level are compared quantitatively to conventional surveys. Two case studies are shown from the COAST3D project field sites at Egmond aan Zee in the Netherlands and at Teignmouth in the United Kingdom.
A Novel Prognostic Four-Gene Signature of Breast Cancer Identified by Integrated Bioinformatics Analysis (2022)

Molecular analysis facilitates the prediction of overall survival (OS) of breast cancer and decision-making of the treatment plan. The current study was designed to identify new prognostic genes for breast cancer and construct an effective prognostic signature with integrated bioinformatics analysis. Differentially expressed genes in breast cancer samples from The Cancer Genome Atlas (TCGA) dataset were filtered by univariate Cox regression analysis. The prognostic model was optimized by the Akaike information criterion and further validated using the TCGA dataset (<i>n</i> = 1014) and Gene Expression Omnibus (GEO) dataset (<i>n</i> = 307). The correlation between the risk score and clinical information was assessed by univariate and multivariate Cox regression analyses. Functional pathways in relation to high-risk and low-risk groups were analyzed using gene set enrichment analysis (GSEA). Four prognostic genes (<i>EXOC6</i>, <i>GPC6</i>, <i>PCK2</i>, and <i>NFATC2</i>) were screened and used to construct a prognostic model, which showed robust performance in classifying the high-risk and low-risk groups. The risk score was significantly related to clinical features and OS. We identified 19 functional pathways significantly associated with the risk score. This study constructed a new prognostic model with a high prediction performance for breast cancer. The four-gene prognostic signature could serve as an effective tool to predict prognosis and assist the management of breast cancer patients.