gebhart/patrepeval huggingface dataset:
A Service Framework for Multi-tenant Enterprise Application in SaaS Environments (2014)

In recent years, Software as a service (SaaS), a service model for cloud computing, has received a lot of attention. As designing a multi-tenant enterprise application in SaaS environments is a non-trival task, we propose a service framework to deal with three common issues for designing multi-tenant enterprise SaaS applications: tenant context storage and propagation, schema-mapping, and the integration of ORM framework. A prototype and a sample SaaS application have been implemented to verify the feasibility of our framework. In addition, two tenant-specific virtual applications are constructed to demonstrate multi-tenancy. Finally, we conduct a set of experiments to assess the overheads of making an enterprise application multi-tenant enabled.
Universal primers for HBV genome DNA amplification across subtypes: a case study for designing more effective viral primers (2007)

Researchers can extend the method described here to design universal or subtype specific primers for various types of viruses. The BxB program based on multiple sequence alignment not only can be used as a separate tool but also can be integrated in any open source primer design software to select conserved regions for primer design.
Application of STAP in Advanced Sensor Systems (2003)

Space time adaptive processing (STAP) is a multidimensional analog of the well-known, one-dimensional adaptive sidelobe canceler developed in the late 1950's. It enables adaptive cancellation of interference in a two-dimensional space. When the two-dimensional target power spectral density differs from that of the interference, STAP leads to enormous improvements in target detection potential. Owing to this potential, STAP has application to current and future airborne, spaceborne, bistatic and ground-based radar sensors; in this set of lecture notes, we consider the role STAP plays in each of these systems. We begin with the airborne case, describing the nature of ground clutter and its impact on target detection. This serves as segue to a discussion of STAP and its comparison with competing methods. Next, we consider spaceborne radar systems. Since STAP is a member of the class of super-resolution algorithms, it enables the design of spaceborne moving target indication radar with smaller aperture; this is an important consideration when launching the satellite radar system. Bistatic systems must contend with spectrally severe ground clutter returns, for which STAP offers a potential solution. Herein, we describe bistatic STAP, with particular emphasis on the nonstationary nature of the bistatic clutter environment. We conclude by considering STAP application to terrain scattered jamming; ground based radar serves as the focus of this final discussion.
A NEW APPROACH TO TESTING FOR CHAOS, WITH APPLICATIONS IN FINANCE AND ECONOMICS (1993)

Whether certain financial and economic time series exhibit chaotic behavior is an issue currently in dispute. Empirical research on chaotic behavior in such data has been hampered by lack of an adequate test. Metric methods do not produce reliable results when applied to small, noisy data sets. Thus, reported results have been inconclusive. Here we apply a new, topological approach to analyzing for chaos, recently developed in the physics literature, to a number of financial and economic series previously subjected to metric tests. The results of the topological test are compared with those reported in the literature using metric methods.
Purified CD34+ Lin- Thy+ stem cells do not contain clonal myeloma cells (1995)

High-dose therapy with autologous marrow or peripheral blood stem cell (PBSC) rescue has been extensively applied in the treatment of multiple myeloma (MM) patients during the past 10 years resulting in improved event-free and overall survival when compared with standard chemotherapy. However, relapses are common and cure is unlikely in the majority of patients. Because both bone marrow and PBSCs are contaminated with myeloma cells it is conceivable that relapse after autotransplantation originates at least in part from autografted tumor cells. In this study, mobilized PBSCs were examined for the presence of myeloma cells based on immunophenotyping and sensitive polymerase chain reaction (PCR)-based techniques. In addition, CD34+ Lin- Thy+ stem cells were purified from mobilized PBSC harvests of 10 MM patients by sequentially using counterflow elutriation centrifugation, treatment with phenylalanine methylester, and flow sorting, using 5-parameter gating (propidium iodide, forward scatter, side scatter, CD34+ v Lin- and CD34+ v Thy+). Virtually all mobilized unsorted PBSC preparations contained myeloma cells in sufficient quantities (range, < 0.01 to > 10%) potentially causing a disease relapse. Stem cell purification led to an overall enrichment by about 50-fold in all 10 patients; approximately 90% of the final cell population expressed CD34+ Lin- Thy+ with no evidence of myeloma cell contamination based on flow cytometric analysis of CD38bright cells (< 0.1%). Quantitative PCR amplification of patient-specific complementarity determining region III (CDRIII) DNA sequences showed depletion of clonal B cells by 2.7 to 7.3 logs, with the highest log reduction noted in the samples initially containing the most tumor cells. Our results show that purification of CD34+ Lin- Thy+ cells depletes myeloma cells to undetectable levels from up to 10% present in unsorted PBSCs, thus offering a tool to investigate whether MM relapse after autotransplantation can be reduced markedly.
Design and analysis of a mechanism for enhanced flexibility in minimally invasive surgical instruments (2010)

Minimally invasive surgeries require precise and dexterous movements which are difficult to perform by means of rigid instruments. In this paper, we present the design and analysis of a mechanism for flexibility in minimally invasive surgical instruments. The designed mechanism is cable-driven and it provides 4DOF degrees of freedom. The mechanism consists of three main components including wrist, cables and back end mechanism and end effector. The goal behind this work is to give the surgeon the possibility of orienting the tip of the surgical instrument directly in a more natural way.
Functional electrical stimulation post-spinal cord injury improves locomotion and increases afferent input into the central nervous system in rats (2013)

Hind limb rehabilitation with FES is an effective strategy to improve locomotion during the acute phase post-SCI. The results of this study indicate that after FES, the CNS preserves/acquires the capacity to respond to peripheral electrical stimulation.
A Decoupled Architecture for Application-Specific File Prefetching (2002)

Data-intensive applications such as multimedia and data mining programs may exhibit sophisticated access patterns that are difficult to predict from past reference history and are different from one application to another. This paper presents the design, implementation, and evaluation of an automatic application-specific file prefetching (AASFP) mechanism that is designed to improve the disk I/O performance of application programs with such complicated access patterns. The key idea of AASFP is to convert an application into two threads: a computation thread, which is the original program containing both computation and disk I/O, and a prefetch thread, which contains all the instructions in the original program that are related to disk accesses. At run time, the prefetch thread is scheduled to run suciently far ahead of the computation thread, so that disk blocks can be prefetched and put in the file buffer cache before the computation thread needs them. Through a source-to-source translator, the conversion of a given application into two such threads is made completely automatic. Measurements on an initial AASFP prototype under Linux show that it provides as much as 54% overall performance improvement for a volume visualization application.
The AMPK-FoxO3A axis as a target for cancer treatment (2010)

FoxO proteins are an evolutionarily conserved subfamily of transcription factors involved in tumor suppression, regulation of energy metabolism and development in several tissues, and are mainly regulated by phosphorylation-dependent nuclear/cytoplasmic shuttling. The transcriptional activity of FoxO3A, one of the four members of the family, is further modulated by AMPK, one of the key regulators of cellular metabolism, which basically shifts cell machinery from energy-consuming to energy-producing pathways. We recently demonstrated that the AMPK/FoxO3A energy sensor pathway is still inducible in human cancer cells in response to metabolic stress, as it becomes activated in colorectal and ovarian cancer cells in response to the inhibition of p38α. Activation of the FoxO3A transcriptional program initially induces autophagy as an attempt to retain energy to survive, whereas under persistent stress conditions it triggers autophagic cell death. In this review, we focus on the connections between AMPK and FoxO3A, describing their central role as modulators of fundamental processes such as stress resistance, cell metabolism, autophagy and cell death, and highlighting the therapeutic potential of pharmacological modulation of the AMPK-FoxO3A axis.
Optimum linear diversity receivers for mobile communications (1994)

This paper analyzes and quantifies the performance of a space diversity combining receiver operating in a mobile radio environment with quaternary phase-shift-keying transmission, frequency-selective Rayleigh multipath fading, and cochannel interference (CCI). The receiver has an infinite-length filter in each branch of the diversity combiner, and the filters are optimized jointly according to the minimum mean-square-error criterion. The link bit error rate is estimated accurately using Metzger's (1987) algorithm, which approximates the probability density function of the combined intersymbol interference (ISI) and CCI. The authors present numerical performance results showing the influence of the diversity order, the number of dominant cochannel interferers, the multipath channel's delay spectrum, and the root-mean-square delay spread. The results show that, under certain conditions, the optimum linear receiver can almost completely eliminate all ISI and CCI while providing near-optimum noise filtering.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Phosphoprotein of the Rinderpest Virus Forms a Tetramer through a Coiled Coil Region Important for Biological Function (2004)

Phosphoprotein (P) of negative sense RNA viruses functions as a transcriptional transactivator of the viral polymerase (L). We report here the characterization of oligomeric P protein of rinderpest virus (RPV) and provide a structural basis for its multimerization. By size exclusion chromatography and dynamic light scattering analyses we show that bacterially expressed P protein exists as an oligomer, thus excluding the role of phosphorylation in P protein oligomerization. Gel filtration analyses of various parts of the P protein, also expressed in Escherichia coli, revealed that the predicted coiled coil region in the C-terminal domain is responsible for P protein oligomerization. Dynamic light scattering analysis confirmed the oligomeric nature of the coiled coil region of P. Chemical cross-linking analysis suggested that the C-terminal coiled coil region exists as a tetramer. The tetramer is formed by coiled coil interaction as shown by circular dichroism spectral analysis. Based on sequence homology, we propose a three-dimensional structure of the multimerization domain of RPV P using the crystal structure for multimerization domain of sendai virus (SeV) P as a template. Four-stranded coiled coil structure of the model is stabilized by a series of interactions predominantly between short nonpolar side chains emerging from different strands. In an in vivo replication/transcription system using a synthetic minigenome of RPV, we show that multimerization is essential for P protein function(s), and the multimerization domain is highly conserved between two morbilliviruses namely RPV and peste de petits ruminants virus. These results are discussed in the context of biological functions of P protein among various negative-stranded RNA viruses.
Alginate-based pellets prepared by extrusion/spheronization: Effect of the amount and type of sodium alginate and calcium salts (2007)

Pellets containing microcrystalline cellulose (MCC), a model drug (theophylline) and a range of levels of sodium alginate (i.e., 10-50% w/w) were prepared by extrusion/spheronization. Two types of sodium alginate were evaluated with and without the addition of either calcium acetate or calcium carbonate (0, 0.3, 3 and 10% w/w). The effects of amount and type of sodium alginate and calcium salts on pellet properties, e.g., size, shape, morphology and drug release behavior, were investigated. Most pellet formulations resulted in pellets of a sufficient quality with respect to size, size distribution and shape. The results showed that the amounts of sodium alginate and calcium salts influenced the size and shape of the obtained pellets. However, different types of sodium alginate and calcium salt responded to modifications to a different extent. A cavity was observed in the pellet structure, as seen in the scanning electron micrographs, resulting from the forces involved in the spheronization process. Most of pellet formulations released about 75-85% drug within 60 min. Incorporation of calcium salts in the pellet formulations altered the drug release, depending on the solubility of the calcium salts used. The drug release data showed a good fit into both Higuchi and Korsmeyer-Peppas equations.
Estradiol Suppresses NF-κB Activation through Coordinated Regulation of let-7a and miR-125b in Primary Human Macrophages (2010)

Previous findings suggest that 17beta-estradiol (estradiol) has a suppressive effect on TNF-alpha, but the mechanism by which estradiol regulates TNF-alpha expression in primary human macrophages is unknown. In this article, we demonstrate that pretreatment of human macrophages with estradiol attenuates LPS-induced TNF-alpha expression through the suppression of NF-kappaB activation. Furthermore, we show that activation of macrophages with LPS decreases the expression of kappaB-Ras2, an inhibitor of NF-kappaB signaling. Estradiol pretreatment abrogates this decrease, leading to the enhanced expression of kappaB-Ras2 with LPS stimulation. Additionally, we identified two microRNAs, let-7a and miR-125b, which target the kappaB-Ras2 3' untranslated region (UTR). LPS induces let-7a and inhibits miR-125b expression in human macrophages, and pretreatment with estradiol abrogates these effects. 3'UTR reporter assays demonstrate that let-7a destabilizes the kappaB-Ras2 3'UTR, whereas miR-125b enhances its stability, resulting in decreased kappaB-Ras2 in response to LPS. Our data suggest that pretreatment with estradiol reverses this effect. We propose a novel mechanism for estradiol inhibition of LPS-induced NF-kappaB signaling in which kappaB-Ras2 expression is induced by estradiol via regulation of let-7a and miR-125b. These findings are significant in that they are the first to demonstrate that estradiol represses NF-kappaB activation through the induction of kappaB-Ras2, a key inhibitor of NF-kappaB signaling.
From marine plants to photovoltaic devices (2013)

We demonstrated that extracts from sea tangle can serve as a sensitizer, redox couple, as well as a counter electrode material, or even can be fabricated into an “all-natural solar cell”. Especially, the carbon counter electrode from sea tangle has achieved a comparable performance with Pt, favorable for the cost-reduction of DSCs.
Overview of Contemporary Penile Rehabilitation Therapies (2008)

Introduction. Post-prostatectomy erectile dysfunction affects a considerable number of men and is a significant quality of life issue. There has been a substantial amount of research on the treatment of post-prostatectomy ED, and now there is a rising interest in the concept of penile rehabilitation. The goal of penile rehabilitation is to moderate the destructive processes that occur after prostatectomy in order to preserve erectile function, either through spontaneous or assisted means. Methods. We reviewed published data and experiences of post-prostatectomy penile rehabilitation using regimented interventions of phosphodiesterase inhibitors, vacuum erectile device, and intracavernosal agents, and we present and analyze the research conducted. Results. These studies show improved objective and subjective clinical outcomes in regards to physical parameters, sexual satisfaction, and rates of spontaneous erections. Conclusion. These studies are often limited by small size, study period, and study design. There continues to be a need for large, randomized, placebo controlled trials with adequate followup to fully evaluate the efficacy and cost-effectiveness of the various proposed penile rehabilitation regiments before a clear standard can be established.
Coprecipitated nickel–alumina catalysts for methanation at high temperature. Part 2.—Variation of total and metallic areas as a function of sample composition and method of pretreatment (1981)

Results are presented for the total and metallic nickel areas of a series of coprecipitated nickel–alumina catalysts prepared and pretreated in different ways. The total areas of the samples decrease on reduction and with increasing reduction temperature, while the nickel area increases with reduction temperature. Increasing calcination temperature causes a decrease in total and nickel areas, this being particularly marked at high temperatures of calcination. A model for the catalyst system is proposed, based on these results and on complementary structural investigations. The high stability of the catalysts is attributed to the presence in the unreduced catalyst of nickel oxide rich phases containing dissolved aluminium ions; on reduction, alumina crystallises on the surface of the growing nickel crystallites, preventing sintering of the catalysts except under extreme conditions.
Serum High-Sensitivity Cardiac Troponin T Is a Significant Biomarker of Left-Ventricular Diastolic Dysfunction in Subjects with Non-Diabetic Chronic Kidney Disease (2011)

These data suggest that hs-cTnT may be a useful biomarker of LVDD in non- diabetic CKD patients.
Reversing drug resistance of cisplatin by hsp90 inhibitors in human ovarian cancer cells. (2015)

Exposure of SKOV3/DDP cells to Hsp90 inhibitors and DDP in combination results in synergistic cytotoxic and pro-apoptotic effects. Hsp90 inhibitors reverse the drug resistance of SKOV3/DDP cells to DDP by modifying the expression of multiple drug resistance related genes.
Cholinergic and opioid mediation of traumatic brain injury. (1992)

There is considerable evidence for the involvement of cholinergic and opioid systems in the pathophysiological responses associated with traumatic brain injury (TBI). To some extent, interest in this area has been eclipsed by a strong focus on, and rapid progress in, studies of the role of excitatory amino acids in TBI. We present evidence that both cholinergic and opioid systems are important modulators of the pathophysiological response to TBI, potentially equally as important as excitatory amino acids. There is a relatively large body of experimental data documenting the involvement of these systems in TBI that has yielded important principles with general significance for laboratory studies of the neuropharmacology of TBI. In fact, the first demonstration of excitotoxic mechanisms of TBI involved studies of the role of acetylcholine in experimental TBI. There also are clinical data suggesting that modulation of opioid and cholinergic systems could benefit patients.
Identification of COPD Patients’ Health Status Using an Intelligent System in the CHRONIOUS Wearable Platform (2014)

The CHRONIOUS system offers an integrated platform aiming at the effective management and real-time assessment of the health status of the patient suffering from chronic obstructive pulmonary disease (COPD). An intelligent system is developed for the analysis and the real-time evaluation of patient's condition. A hybrid classifier has been implemented on a personal digital assistant, combining a support vector machine, a random forest, and a rule-based system to provide a more advanced categorization scheme for the early and in real-time characterization of a COPD episode. This is followed by a severity estimation algorithm which classifies the identified pathological situation in different levels and triggers an alerting mechanism to provide an informative and instructive message/advice to the patient and the clinical supervisor. The system has been validated using data collected from 30 patients that have been annotated by experts indicating 1) the severity level of the current patient's health status, and 2) the COPD disease level of the recruited patients according to the GOLD guidelines. The achieved characterization accuracy has been found 94%.
Self-Assembled Microslider for Microjoinery (1998)

Abstract MicroJoinery is an attractive concept to create precise translational movement for such components as optomechanical micro-accessories due to the readiness of silicon etching techniques. Basic fabrication of the dovetail MicroJoints uses anisotropic etching of (100) silicon wafers and fusion bonding. This paper focuses on a new fabrication method of self-assembly of the translational stage using a sacrificial layer and an electroplated microriveting technique, eliminating the need for wafer bonding and manual assembly. The slider is made from a double-side polished wafer and slides on substrate guided by a guide rail. The clearance between the sliding parts defined by the thickness of sacrificial layer is much smaller and repeatable than what bulk micromachining and manual assembly could provide. The coefficient of static friction was measured to be 0.42–0.78 in air for the self-assembled microslider with an added weight (3.5 g). For manually assembled dovetail MicroJoinery devices coated with silicon nitride, friction coefficient of around 0.302 was obtained.
Global Maxwell Tomography using an 8-channel radiofrequency coil: simulation results for a tissue-mimicking phantom at 7T (2019)

We simulated a Global Maxwell Tomography experiment for the estimation of electrical properties in a numerical tissue-mimicking phantom using a decoupled 8 channel radiofrequency coil designed for 7 Tesla magnetic resonance scanners. The goal of this work was to investigate whether the orthogonality of the coil’s transmit fields ($b_1^ + $ measurements) is required to ensure accurate results. We demonstrated a normalized root mean squared error smaller than 0.6% with respect to the true electrical properties distribution. Our results showed that electrical properties reconstruction with Global Maxwell Tomography is accurate and robust.
Detecting dangerous coordination ambiguities using word distribution (2007)

In this paper we present heuristics for resolving coordination ambiguities.We test the hypothesis that the most likely reading of a coordination can be predicted using word distribution information from a generic corpus.Our heuristics are based upon the relative frequency of the coordination in the corpus, the distributional similarity of the coordinated words, and the collocation frequency between the coordinated words and their modifiers.These heuristics have varying but useful predictive power.They also take into account our view that many ambiguities cannot be effectively disambiguated, since human perceptions vary widely.