gebhart/patrepeval huggingface dataset:
The phenotype of limb-girdle muscular dystrophy type 2I (2003)

LGMD2I due to FKRP mutations appears to be a relatively common cause of LGMD, with respiratory and cardiac failure as prominent complications.
Real time complex event detection for resource-limited multimedia sensor networks (2011)

This paper presents a real-time complex event detection concept for resource-limited multimedia sensor networks. A comprehensive solution based on Answer Set Programming (ASP) is developed. We show that ASP is an appropriate solution to detect a large number of simple and complex events (video-audio understanding) on platforms with limited resources e.g. power consumption, memory and processing power. We underline the major problems of the existing paradigms for complex event detection (based on e.g. logic programming and SemanticWeb), with a special focus on the major challenges which reduce the performance of real-time event detection. Finally, we demonstrate the high performance of ASP compared to that of Semantic Web.
LSTM network: a deep learning approach for short‐term traffic forecast (2017)

Short‐term traffic forecast is one of the essential issues in intelligent transportation system. Accurate forecast result enables commuters make appropriate travel modes, travel routes, and departure time, which is meaningful in traffic management. To promote the forecast accuracy, a feasible way is to develop a more effective approach for traffic data analysis. The availability of abundant traffic data and computation power emerge in recent years, which motivates us to improve the accuracy of short‐term traffic forecast via deep learning approaches. A novel traffic forecast model based on long short‐term memory (LSTM) network is proposed. Different from conventional forecast models, the proposed LSTM network considers temporal–spatial correlation in traffic system via a two‐dimensional network which is composed of many memory units. A comparison with other representative forecast models validates that the proposed LSTM network can achieve a better performance.
Differential Effects of Bariatric Surgery Versus Exercise on Excessive Visceral Fat Deposits (2016)

The aim of the present study was to compare differential impacts of bariatric surgery and exercise-induced weight loss on excessive abdominal and cardiac fat deposition.Excessive fat accumulation around the heart may play an important role in the pathogenesis of cardiovascular disease. Recent evidences have suggested that bariatric surgery results in relatively less decrease in epicardial fat compared with abdominal visceral fat and paracardial fat.Sixty-four consecutive overweight or obese subjects were enrolled in the study. Clinical characteristics and metabolic profiles were recorded. The volumes of abdominal visceral adipose tissue (AVAT), abdominal subcutaneous adipose tissue (ASAT), epicardial (EAT), and paracardial adipose tissue (PAT) were measured by computed tomography in the bariatric surgery group (N = 25) and the exercise group (N = 39) at baseline and 3 months after intervention. Subjects in both the surgery and exercise groups showed significant reduction in body mass index (15.97%, 7.47%), AVAT (40.52%, 15.24%), ASAT (31.40, 17.34%), PAT (34.40%, 12.05%), and PAT + EAT (22.31%, 17.72%) (all P < 0.001) after intervention compared with baseline. In both the groups, the decrease in EAT was small compared with the other compartments (P < 0.01 in both groups). Compared with the exercise group, the surgery group had greater loss in abdominal and cardiac visceral adipose tissue (AVAT, ASAT, PAT, EAT+PAT) (P < 0.001), but lesser loss in EAT (P = 0.037).Compared with the exercise group, bariatric surgery results in significantly greater percentage loss of excessive fat deposits except for EAT. EAT, but not PAT, was relatively preserved despite weight reduction in both the groups. The physiological impact of persistent EAT deserves further investigation.
Language-Based Isolation of Untrusted JavaScript (2009)

Web sites that incorporate untrusted content may use browser- or language-based methods to keep such content from maliciously altering pages, stealing sensitive information, or causing other harm. We study language-based methods for filtering and rewriting JavaScript code, using Yahoo! ADSafe and Facebook FBJS as motivating examples. We explain the core problems by describing previously unknown vulnerabilities and subtleties, and develop a foundation for improved solutions based on an operational semantics of the full ECMA-262 language. We also discuss how to apply our analysis to address the JavaScript isolation problems we discovered.
Characterization and Phytotoxicity Assessment of Essential Oils from Plant Byproducts (2019)

The present work describes the chemical characterization and the phytotoxicity assessment of essential oils (EOs) obtained from spent materials or pruning waste of four plant species: <i>Zingiber officinale</i> Roscoe used in the juicing industry, <i>Pistacia vera</i> L. var. <i>Bronte</i> used in the food industry, discarded material of industrial hemp (<i>Cannabis sativa</i> L. var. <i>Futura 75</i>), and pruning waste from <i>Cupressus sempervirens</i> L. The phytochemical profile of the EOs was evaluated by gas chromatographic flame ionization detection (GC-FID) and GC-MS analyses, which highlighted the presence of several compounds with a wide range of biological activities. Among them, application possibilities in agriculture were evaluated by studying the phytotoxic activity <i>in vitro</i> against germination and initial radical growth of several seeds such as <i>Raphanus sativus</i> L., <i>Lepidium sativum</i> L., <i>Lactuca sativa</i> L., <i>Solanum lycopersicum</i> L., <i>Lolium multiflorum</i> Lam., and <i>Portulaca oleracea</i> L.
Functionalized silica gel as a support for solid-phase organic synthesis (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFunctionalized silica gel as a support for solid-phase organic synthesisJohn F. W. Keana, Masato Shimizu, and Karen K. JernstedtCite this: J. Org. Chem. 1986, 51, 10, 1641–1644Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://doi.org/10.1021/jo00360a001RIGHTS & PERMISSIONSArticle Views509Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (584 KB) Get e-Alerts Get e-Alerts
Simplify your HV-harness &#x2014; Uniform high current connectors for batteries, inverters and motors in heavy-duty vehicles and passenger cars (2010)

The electrification of the power train requires the usage of high current connectors at various different system components such as batteries, inverters, electric motors or power distribution units. Modularized manufacturing processes and service requirements support the need for removable connections. This led to the development of an integrated high current connector family that is applicable for passenger cars but also fulfils the requirements of heavy-duty applications including a uniform mounting and safety concept. Based on the patented 3-zone high current HICCON II contact system for 35mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 50mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> cables, straight and angled 2- and 3-pole connectors were designed, manufactured, tested and applied.
The year in cognitive neuroscience (2008)

The 2011 volume of The Year in Cognitive Neuroscience presents leading scientists current thinking on topics including: challenges and opportunities in social neuroscience; the neurobiological basis of seeing words; bayesian models of uncertainty, behavior, and the brain; behavioral and neural evidence for the porous boundaries between explicit and implicit memory;perception of auditory signals; human category learning 2.0; animal emotion; and the human connectome. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please click here. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation (2008)

This study suggests that neuro-inflammatory reaction could contribute to AD pathology, and anti-inflammatory agent could be useful for the prevention of AD.
Morphogenesis of Bacteriophage φ29 of <i>Bacillus subtilis</i> : Mapping and Functional Analysis of the Head Fiber Gene (1977)

A set of mutants of Bacillus subtilis bacteriophage phi29 unable to synthesize the head fiber protein has been identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and autoradiography. Infectious phage are produced during restrictive infection. We have focused on mutant sus 8.5(900) because the mutation is suppressible by both the su(+3) and su(+44) hosts, and it can be mapped by three- and four-factor crosses. After restrictive infection with mutant sus 8.5(900), a fragment about 70% of the size of the normal fiber is produced as well as particles that are fast-sedimenting in sucrose gradients relative to phi29(+). These particles have the buoyant density of particles with the fibers removed and have the absolute plating efficiency of phi29(+). Fiber protein is absent from prohead as well as virion. A second set of mutants produces fiber protein with a slightly altered electrophoretic mobility. This type of fiber protein is either present or absent on both prohead and virion. A third class of mutants, typified by 914, produces a "normal" fiber, but a major head protein of altered electrophoretic mobility. After infection by this mutant, the fiber is absent from both prohead and virion, and the biological and physical properties of the 914(-) particle are similar to those of particles produced after infection of the su(-) host by sus8.5(900). These observations suggest that the head fiber is not an essential component of the prohead or virion and that the assembly process is efficient in the absence of fiber protein. Three- and four-factor genetic crosses have established the order sus8(769)-8(914)-sus8.5(900)-sus9(756) and indicate that cistrons 8 and 8.5 code for the major head protein and head fiber protein, respectively.
Enhanced hybrid drive scheme for power saving in wireless ad-hoc networks (2013)

The wireless networks have become an integral component of the modern communication system. The mobile terminals have limited battery life. Also ad-hoc networks are used in situations like disaster management, battlefield etc. where the resources available for battery recharge would be limited. Hence energy efficiency is an important design criterion for ad-hoc networks. IEEE 802.11 provides a mechanism known as PSM (Power saving mechanism) in MAC layer which reduces the power consumption by the transition of mobile stations between awake and doze state. Here the energy efficiency is high when the network load is small but decreases with the increase in network load. For RTS-CTS scheme, the energy efficiency is high when the network load is heavy. Hybrid Drive Scheme (HDS) combines RTS-CTS scheme with the conventional PSM so that energy efficiency is high even if the network load is light or heavy. But after each data transmission, beacon frames are transmitted which cause additional energy wastage. This paper presents a novel energy saving mechanism, called as Enhanced Hybrid Drive Scheme (E-HDS), which extract the features of PSM as well as RTS-CTS scheme. Here a single beacon frame is transmitted per beacon interval which reduces energy wastage. Hence E-HDS out-performs HDS. Also E-HDS could obtain high energy efficiency than conventional scheme in the IEEE 802.11 standard irrespective of the network load conditions.
Isolation and Characterization of P1 Adhesin, a Leg Protein of the Gliding Bacterium <i>Mycoplasma pneumoniae</i> (2010)

Mycoplasma pneumoniae, a pathogen causing human pneumonia, binds to solid surfaces at its membrane protrusion and glides by a unique mechanism. In this study, P1 adhesin, which functions as a "leg" in gliding, was isolated from mycoplasma culture and characterized. Using gel filtration, blue-native polyacrylamide gel electrophoresis (BN-PAGE), and chemical cross-linking, the isolated P1 adhesin was shown to form a complex with an accessory protein named P90. The complex included two molecules each of P1 adhesin and P90 (protein B), had a molecular mass of about 480 kDa, and was observed by electron microscopy to form 20-nm-diameter spheres. Partial digestion of isolated P1 adhesin by trypsin showed that the P1 adhesin molecule can be divided into three domains, consistent with the results from trypsin treatment of the cell surface. Sequence analysis of P1 adhesin and its orthologs showed that domain I is well conserved and that a transmembrane segment exists near the link between domains II and III.
GaussSketch (2012)

This work presents GaussSketch, a retrofit stylus sensing extension to enable the detection of stylus tilt and pressure for natural sketch simulation on smartphones by utilizing magnetism. Attaching the compatible sensor grid on the back of a conventional smartphone can (1) sense the stylus' tilt degrees and pressure values, (2) discriminate the touch events generated by a finger or the stylus, and (3) detect where the stylus hovers upon the screen.
Molecular Evolution of Plant RNA Viruses (1986)

Beneficial microbes in the microbiome of plant roots improve plant health. Induced systemic resistance (ISR) emerged as an important mechanism by which selected plant growth–promoting bacteria and fungi in the rhizosphere prime the whole plant body for ...Read More
Stabilization of platelet-fibrinogen interactions is an integral property of the glycoprotein IIb-IIIa complex. (1994)

Fibrinogen binding to platelets is multiphasic and culminates in the stabilization of platelet-fibrinogen interactions characterized by the resistance of bound fibrinogen to dissociation by ethylenediaminetetraacetic acid (EDTA) or excess unlabeled fibrinogen. Controversy exists, however, with regard to the exclusive role of the glycoprotein IIb-IIIa (GPIIb-IIIa) complex in this process. Thus the reversibility of fibrinogen binding to purified GPIIb-IIIa and GPIIb-IIIa activated by a monoclonal antibody (D3) on otherwise resting platelets was examined. GPIIb-IIIa was isolated by affinity chromatography on concanavalin A followed by gel filtration on Sephacryl S-300 and immobilized directly on plastic microtiter wells or immunocaptured by immobilized anti-GPIIb or GPIIIa antibodies. The extent of GPIIb-IIIa deposition, 0.14 to 0.27 pmol/well, was determined by using a monoclonal, anti-GPIIb-IIIa antibody (10E5). Maximum fibrinogen binding occurred after 60 minutes at 22 degrees C in the presence of 300 micrograms/ml fibrinogen, when 0.014 to 0.030 pmol fibrinogen bound per well. Assuming a 1:1 relationship between fibrinogen binding and GPIIb-IIIa occupancy, these data suggest that approximately 10% to 20% of immobilized GPIIb-IIIa was in an active confirmation. After 60 minutes, 65% +/- 13% of bound fibrinogen was resistant to dissociation by excess unlabeled fibrinogen, and 53% +/- 24% failed to dissociate with 10 mmol/L EDTA. Fibrinogen fragment D1 also bound irreversibly to immobilized GPIIb-IIIa (52% +/- 18%).(ABSTRACT TRUNCATED AT 250 WORDS)
Partying on? Life after BZP-based party pills. (2008)

The withdrawal of BZP and any replacement 'party pills' from the recreational drug market may lead to an increase in the use of illegal drugs.
Cover Image, Volume 49, Issue 6 (2017)

The cover image, by Jihye Lee et al., is based on the Research Article Investigation of Asian lacquer films using ToF-SIMS and complementary analytical techniques, DOI 10.1002/sia.6181.
A comparative study of muscle spindles in slow and fast neonatal muscles of normal and dystrophic mice (1986)

Muscle spindles from the slow-twitch soleus and the fast-twitch extensor digitorum longus (EDL) muscles of genetically dystrophic mice of the dy2J/dy2J strain were compared with age-matched normal animals at neonatal ages of 1-3 weeks according to histochemical, quantitative, and ultrastructural parameters. Intrafusal fibers in both the soleus and EDL exhibited similar regional differences in myosin ATPase activity, and conformed to those noted previously in various adult species. In distal polar regions, all nuclear bag fibers resembled extrafusal fibers of the type 1 variety, whereas in capsular zones they could be divided into two subtypes. Nuclear chain fibers possessed a staining pattern similar to type 2 extrafusal fibers, and in contrast to the bag fibers they exhibited no regional variations. These features were consistently observed in both the normal and dystrophic muscles at all ages. Spindles varied only slightly in their number and distribution in the two types of muscle, and their location followed the neurovascular branching pattern in each. Irrespective of age or genotype, spindles in the soleus were more homogeneously dispersed, but those in the EDL were concentrated along the dorsal aspect of the muscle. No significant differences were noted in the total number of spindles between normal and dystrophic muscles. In addition, no dramatic differences were observed in the muscle spindle index for soleus and EDL. The first obvious disease-related changes were noted in extrafusal fibers of the soleus of 3-week-old mice, and spindles were often located close to these areas of fiber degeneration. Despite alterations in the surrounding tissue, however, spindles appeared morphologically unaltered in dystrophy. These observations indicate that intrafusal fibers of spindles in neonatal mice appear enzymatically and histologically unaffected in incipient stages of progressive muscular dystrophy.
Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca <sup>2+</sup> (2011)

Epidemiological and experimental evidence indicates that nicotine is protective for Parkinson disease vulnerable dopamine neurons, but the underlying mechanism of this effect remains only partly characterized. To address this question, we established rat midbrain cultures maintained in experimental conditions that favor the selective and spontaneous loss of dopamine neurons. We report here that nicotine afforded neuroprotection to dopamine neurons (EC(50)=0.32 μM) but only in a situation where cytosolic Ca(2+) (Ca(2+)(cyt)) was slightly and chronically elevated above control levels by concurrent depolarizing treatments. By a pharmacological approach, we demonstrated that the rise in Ca(2+)(cyt) was necessary to sensitize dopamine neurons to the action of nicotine through a mechanism involving α-bungarotoxin-sensitive (presumably α7) nicotinic acetylcholine receptors (nAChRs) and secondarily T-type voltage-gated calcium channels. Confirming the role played by α7 nAChRs in this effect, nicotine had no protective action in midbrain cultures prepared from genetically engineered mice lacking this receptor subtype. Signaling studies revealed that Ca(2+)(cyt) elevations evoked by nicotine and concomitant depolarizing treatments served to activate a survival pathway involving the calcium effector protein calmodulin and phosphatidylinositol 3-kinase. Collectively, our data support the idea that the protective action of nicotine for dopamine neurons is activity-dependent and gated by Ca(2+)(cyt).
Adaptation to displaced and delayed visual feedback from the hand. (1966)

S viewed an oscilloscope trace of a short bar which appeared at the position of his nonvisible right hand.The motion of the trace was equivalent to the movements of the hand, which were restricted to a frontal plane.The bar could be optically displaced by 20 diopter prisms, either to the left or right, and its motion could be made to lag behind that of the hand by 1 of 6 delay intervals ranging from 0.0 to 3.0 sec.Results show that the adaptation to displacement found with no delay is completely eliminated under all delay intervals, including the minimum of 0.3 sec.
Automatic Pattern Generation Process for Made-to-Measure (2012)

The objectives of this study were to analyze the automatic pattern generation process for making custom fit garment using the made-to-measure (MTM) CAD system, which produces apparel products based on individual body measurements, and to provide basic materials for the utilization of this technology in apparel manufacturing for mass customization. In order to make MTM patterns, basic patterns were digitized by using the Gerber CAD system, and designated critical alteration points based on body measurements important for pattern design. Then, grading rules and alteration rules based on the ASTM 5585 standard sizes were formulated, size tables for entering standard sizes and individual sizes were made, and MTM patterns were generated for custom fit garment according to individual body measurements. In the apparel manufacturing process, the computer-aided design (CAD) system for pattern design has been utilized merely for digitizing and grading patterns, and the application of individual size has usually been made through manual work on the patterns. The MTM CAD system in this study is expected to be utilized as a computer-aided manufacture system for the clothing industry in the age of mass customization and to play an important role in manufacturing custom fit garment reflecting individual customers’ body measurements. Moreover, the MTM CAD system may be usable in the automated pattern generation reflecting individual body measurements.
Gelatin/glycerol coating to preserve mechanically compliant nanowire electrodes from damage during brain implantation (2010)

Chronically implanted neural implants are of clinical importance. However, currently used electrodes have several drawbacks. Some weeks after implantation in the brain, a glial scar forms around the electrode, causing decreased electrode functionality. Nanostructures, and in particular nanowires, are good candidates to overcome these drawbacks and reduce glial scar formation. Using a mechanically compliant substrate with protruding nanowires could further decrease the glial scar formation by reducing the mechanical mismatch between the tissue and the electrode. However, flexible substrates require strengthening upon brain implantation. One solution consists of embedding the implant in a gelatin-based matrix, which is resorbable. In the case where nanostructures are present at the surface of the implant, it is crucial that the embedding matrix also preserves the nanostructures, which can be challenging considering the forces involved during the drying phase of gelatin. Here, the authors show that freestanding gallium phosphide nanowires coated with hafnium oxide (HfO2), titanium (Ti), and gold (Au) were preserved in a gelatin-glycerol embedding matrix with subsequent implantation in 1% agar, which is a model for brain implantation.