gebhart/patrepeval huggingface dataset:
Persistent Aerial Video Registration and Fast Multi-View Mosaicing (2014)

Capturing aerial imagery at high resolutions often leads to very low frame rate video streams, well under full motion video standards, due to bandwidth, storage, and cost constraints. Low frame rates make registration difficult when an aircraft is moving at high speeds or when global positioning system (GPS) contains large errors or it fails. We present a method that takes advantage of persistent cyclic video data collections to perform an online registration with drift correction. We split the persistent aerial imagery collection into individual cycles of the scene, identify and correct the registration errors on the first cycle in a batch operation, and then use the corrected base cycle as a reference pass to register and correct subsequent passes online. A set of multi-view panoramic mosaics is then constructed for each aerial pass for representation, presentation and exploitation of the 3D dynamic scene. These sets of mosaics are all in alignment to the reference cycle allowing their direct use in change detection, tracking, and 3D reconstruction/visualization algorithms. Stereo viewing with adaptive baselines and varying view angles is realized by choosing a pair of mosaics from a set of multi-view mosaics. Further, the mosaics for the second pass and later can be generated and visualized online as their is no further batch error correction.
Formulation and Evaluation of taste masked oral suspension of DextromethorphanHydrobromide (2012)

Taste is an important factor in the development of dosage form. The problem of bitter and obnoxious taste of drug in pediatric and geriatric formulations is a challenge to the pharmacist in the present scenario. In order to ensure patient compliance bitterness masking becomes essential. The purpose of this research was to mask the intensely bitter taste of Dextromethorphan Hydrobromide using ion exchange resin and to formulate oral suspension of the taste masked drug. When suspension is swallowed bitter taste may not be felt because ion exchange resin complex does not release drug at salivary pH. When it comes in contact with acidic environment of stomach, the complex will be broken down releasing the drug which may then absorbed. Batch method was used for formation of drug resin complex. Various ion exchange resins such as Ionex QM 1011, Ionex WC 23 and Kyron T- 114 were tried to obtained taste masked drug resin complex (DRC). Optimization of drug loading was carried out. With Ionex QM 1011, the drug-resin proportion of 1:6 achieved equilibrium in 6 hours. 96% w/w of drug loading was possible by this method. Complex formation was confirmed by DSC and IR studies. Oral taste masked suspension was prepared using xanthum gum and tween 80 and was evaluated with respect to parameters such as Colour, pH, Viscosity, Sedimentation volume, Redispersibility, Assay, drug release. Taste masking was evaluated with the help of panel of human volunteers and Rat Behavioral Avoidance Taste Model. Taste masked suspension showed easy redispersibility and more than 99.6 % of the drug release within 45 minutes at pH 1.2. Thus, results conclusively demonstrated successful taste masking and formulation of suspension with taste masked drug especially for pediatric, geriatric, bedridden, and non cooperative patients.
A TEST HARNESS FOR A CONTROL SOFTWARE (2005)

ii to our FAMILIES with love iii Acknowledgements We wish to express thanks to our supervisor Professor Anders P. Ravn for his guidance and advice. We would also like to thank Engineer Jean of Alphashipmate for providing us with informa-tion the working of an Electronic Control Unit and a marine diesel engine. Our appreciation also goes to Mr Vesa-Matti Puro of OpenTTCN for providing us with the OpenTTCN tool. iv The thesis presents the overall activities involved in model based development of a test har-ness for a control software. This is illustrated by a case study on the Alpha Shipmate control
Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas (2004)

Simvastatin and pravastatin are inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase, and are used as antihypercholesterolemia drugs. Simvastatin, but not pravastatin, binds to the inserted domain of leukocyte function antigen (LFA)-1 and inhibits the function of LFA-1, including adhesion and costimulation of lymphocytes. Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs) express high levels of LFA-1 on their surface and grow in tight clumps. Here we show that simvastatin (2 microM) inhibits clump formation and induces apoptosis of EBV-transformed LCLs. The apoptosis-inducing effect of simvastatin depends on binding to the inserted domain of LFA-1. Simvastatin, but not pravastatin, dissociates EBV latent membrane protein 1 from lipid rafts of LCLs, resulting in down-regulation of nuclear factor kappaB activity and induction of apoptosis. Analysis of multiple EBV-positive and -negative cell lines indicated that both LFA-1 and EBV latent membrane protein 1 expression were required for simvastatin's effects. Administration of simvastatin to severe combined immunodeficiency mice followed by inoculation with LCLs resulted in delayed development of EBV lymphomas and prolonged survival of animals. To our knowledge, this is the first report in which a drug that targets LFA-1 has been used to treat B cell lymphoma. These data suggest that simvastatin may have promise for treatment or prevention of EBV-associated lymphomas that occur in immunocompromised persons.
A stopping criteria for turbo decoding based on the LLR histogram (2012)

The present paper proposes an early stopping method for iterative turbo decoding. Many criterions were proposed to date, motivated by a variety of reasons, such as increasing average decoding throughput or reducing average decoder power consumption. The method is devised on observing the behavior of LLR (Log-Likelihood Ratio). Simulation results in comparing the proposed method with some normalization techniques show that our method achieves an acceptable BER (Bit Error Rate) performance and reduces considerably the average number of iterations.
A novel battery identification method based on pattern recognition (2008)

Development of an intelligent battery diagnostic system is a necessity for future transportation industry. These technologies will have the potential to create profound impact in other industries such as portable electronics. The present article reports on a pattern recognition method that is primarily engineered to detect the chemistry, number of cells, and state of charge in an unknown package of batteries. The proposed technique has the potential to be used for condition monitoring in a known set of batteries thereby, creating a health monitoring apparatus that can be an integral part of a battery management system in an Electric or Hybrid Electric vehicle using any of the prominent lead acid, lithium-ion, and Nicle Metal Hydride batteries. The proposed method is based on distinct signatures that one can identify in a relatively straightforward equivalent circuit of a battery. These signatures are extracted using time domain diagnostics and are used in combination with nonlinear mappings such as exponential regression and artificial neural networks for pattern recognition purposes.
A first step toward a pervasive and smart ZigBee sensor system for assistance and rehabilitation (2009)

This paper shows the general concept and the primary implementation of a pervasive intelligent system for rehabilitation. The scope of this work is to highlight the possibility to join two important research fields, i.e. rehabilitation and ambient assisted living, to enhance the capabilities and independence of disable and aged people. The described system was composed of a ZigBee network, with coordinator, sensor and actuator nodes, able to identify and control patient's activities and send warning to caregiver if requests in warning functionality, and of a software interface to manage the whole network and to monitor patient in outdoor environment.
Storage- and entropy-constrained multi-stage vector quantization (2002)

A design algorithm for a new multistage vector quantizer, called storageand entropy-constrained multi-stage vector quantizer (SECMSVQ), is presented. In SECMSVQ, the rate constraint at each stage of the vector quantizer (VQ), and the storage size of the whole VQ are specified independently before the design. A dynamic programming technique is then used to allocate the storage size to each stage of the VQ optimally so that the quantization distortion of the VQ is minimized. The SECMSVQ, in addition to being able to control the rate and storage size independently, has the property of progressive image transmission (PIT). Simulation results show that SECMSVQ can be used effectively to implement both the signal compression systems and PIT systems.
Pathways for eosinophil lipid body induction: differing signal transduction in cells from normal and hypereosinophilic subjects (1998)

Although lipid bodies, inducible cytoplasmic inclusions active in arachidonic acid metabolism, are abundant in activated leukocytes, including eosinophils, mechanisms for eosinophil lipid body formation are not certain. Eosinophils from hypereosinophilic syndrome (HES) donors contained about twice (approximately 18/cell) as many lipid bodies as eosinophils froin normal donors (approximately 10/cell). By immunocytochemistry both 5- and 15-lipoxygenases were localized at lipid bodies in HES eosinophils. Platelet-activating factor (PAF) induced rapid, receptor-mediated increases in lipid bodies in normal and HES eosinophils. Protein kinase C (PKC) inhibitors, chelerythrine and calphostin C, inhibited PAF-induced lipid body formation partially in normal and HES eosinophils. In HES, but not normal, eosinophils, PAF-induced lipid body formation was completely blocked by two tyrosine kinase inhibitors, herbimycin A and genistein, which were not acting on 5-lipoxygenase because they also blocked 5-HETE-induced lipid body formation in HES, and not normal, eosinophils. After 24 h culture with eosinophil growth factor cytokines [interleukin (IL)-3, IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) or GM-CSF alone but not IL-5 or IL-3 alone], normal eosinophils were induced to exhibit an HES-like phenotype, including increased lipid body numbers and tyrosine kinase-dependent signaling for PAF-induced lipid body formation. Thus, signal transduction mechanisms involved in PAF-induced lipid body formation in eosinophils can be differentially recruited. Tyrosine kinase-dependent signaling is not involved in normal eosinophils, but is active in HES eosinophils and in normal eosinophils cultured with GM-CSF. PKC- and tyrosine kinase-dependent pathways are involved in the formation of eosinophil lipid bodies, which may facilitate enhanced synthesis of lipoxygenase-derived eicosanoids.
The Antiproliferative Effect of Mesenchymal Stem Cells Is a Fundamental Property Shared by All Stromal Cells (2007)

Although it has been widely demonstrated that human mesenchymal stem cells exert potent immunosuppressive effects, there is little information as to whether more mature mesenchymal stromal cells (SC) share the same property. Accordingly, we set out to test the ability of SC from different human tissues to inhibit the proliferation of PBMC following polyclonal stimuli. Chondrocytes, as well as fibroblasts from synovial joints, lung, and skin, were used as a source of SC. Irrespective of their differentiation potential and/or content of progenitor cells, SC from all tissues exhibited antiproliferative functions. This was in marked contrast to parenchymal cells. Although SC did not interfere with early T lymphocyte activation, they arrested stimulated T cells in the G(0)/G(1) phase of the cell cycle and rescued them from apoptosis. In addition, IFN-gamma and TNF-alpha production were reduced. We observed that the inhibitory effect is ultimately mediated by soluble factors, the production of which requires SC to be licensed in an inflammatory environment by cell contact. We conclude that the immunosuppressive effect of mesenchymal cells is not confined to multipotent stem cells, but is a fundamental characteristic of all stroma. Our data suggest that SC, appropriately licensed, regulate T cell homeostasis.
Health-related quality of life in patients with primary Sjögren's syndrome: relationship with serum levels of proinflammatory cytokines (2009)

Patients with pSS showed increased levels of several macrophage- and lymphocyte-derived cytokines, indicating the existence of an immune activation state. Serum levels of one of these cytokines, IL-6, were correlated with poor quality of life in these individuals.
Visual function-specific perimetry for indirect comparison of different ganglion cell populations in glaucoma. (2000)

For detection of functional loss standard visual field testing is not optimum; a combination of two or more tests may improve detection of functional loss in these eyes; in an individual, the same retinal location is damaged, regardless of visual function under test; glaucomatous optic neuropathy identified on stereophotographs may precede currently measurable function loss in some eyes; conversely, function loss with specific tests may precede detection of abnormality by stereophotograph review; and short-wavelength automated perimetry, frequency-doubling perimetry, and motion-automated perimetry continue to show promise as early indicators of function loss in glaucoma.
Unlocking the Latent Antimicrobial Potential of Biomimetically Synthesized Inorganic Materials (2013)

Abstract Inspired by biomineralization, biomimetic approaches utilize biomolecules and synthetic analogs to produce materials of controlled chemistry, morphology, and function under relatively benign conditions. A common characteristic of biological and biomimetic mineral‐forming processes is the generation of mineral/biomolecule nanocomposites. In this work, it is demonstrated that a facile chemical reaction may be utilized to halogenate the nitrogen‐containing moieties of the organics entrapped within bio‐inorganic composites to yield halamine compounds. This process provides rapid and potent bactericidal activity to biomimetically and biologically produced materials that otherwise lack such functionality. Additionally, bio‐inorganic composites containing the chlorinated peptide protamine are effective in rapidly neutralizing Bacillus spores (≥99.97% reduction in colony forming units within 10 min). The straightforward nature of the described process, and the efficacy of halamine compounds in neutralizing biological and chemical agents, provide new applicability to biogenic and biomimetic materials.
can zuo zhong lou he ji dui ji pei rong mao niao nang mo xue guan sheng cheng de ying xiang (2010)

目的:探讨参芪重楼合剂体内对鸡胚绒毛尿囊膜(CAM)血管网生长的影响.方法:利用CAM模型观察参芪重楼合剂对CAM血管网的形成的作用.结果:参芪重楼合剂50 mg/mL对(CAM)血管形成的抑制作用与环磷酰胺0.4 mg/mL的抑制作用相当,均为100%,参芪重楼合剂25、12.5、6.25 mg/mL对于(CAM)血管形成的抑制作用分别为70%、30%、10%.结论:参芪重楼合剂对CAM血管网的...
The canonical pathway for selenocysteine insertion is dispensable in <i>Trypanosomes</i> (2009)

The micronutrient selenium is found in proteins as selenocysteine (Sec), the 21st amino acid cotranslationally inserted in response to a UGA codon. In vitro studies in archaea and mouse showed that Sec-tRNA(Sec) formation is a 3-step process starting with serylation of tRNA(Sec) by seryl-tRNA synthetase (SerRS), phosphorylation of serine to form phosphoserine (Sep)-tRNA(Sec) by phosphoseryl-tRNA(Sec) kinase (PSTK), and conversion to Sec-tRNA(Sec) by Sep-tRNA:Sec-tRNA synthase (SepSecS). However, a complete study of eukaryotic selenoprotein synthesis has been lacking. Here, we present an analysis of Sec-tRNA(Sec) formation in the parasitic protozoon Trypanosoma brucei in vivo. Null mutants of either PSTK or SepSecS abolished selenoprotein synthesis, demonstrating the essentiality of both enzymes for Sec-tRNA(Sec) formation. Growth of the 2 knockout strains was not impaired; thus, unlike mammals, trypanosomes do not require selenoproteins for viability. Analysis of conditional RNAi strains showed that SerRS, selenophosphate synthase, and the Sec-specific elongation factor, EFSec, are also essential for selenoprotein synthesis. These results with T. brucei imply that eukaryotes have a single pathway of Sec-tRNA(Sec) synthesis that requires Sep-tRNA(Sec) as an intermediate.
Chromatin (dis)Organization and Cancer: BUR-binding Proteins as Biomarkers for Cancer (2002)

Malignant transformation of cells is associated with changes in gene expression. Gross alterations in chromatin organization may be involved in such gene dysregulation, as well as the involvement of specific transcription factors. Specialized genomic DNA segments that exhibit high affinity to the nuclear matrix in vitro have been designated as matrix/scaffold attachment regions (MARs/SARs). MARs are postulated to anchor chromatin onto the nuclear matrix, thereby organizing genomic DNA into topologically distinct loop domains that are important in replication and transcription. In support of this notion, MARs often colocalize or exist in close proximity to regulatory sequences including enhancers. Base unpairing regions (BURs) are typically 100-150 bp regions within MARs, possess an intrinsic propensity to unwind under negative superhelical strain, and are considered to be hallmark of MARs. To investigate a potential mechanism that could lead to significant alterations in gene expression in cancer cells, this review focuses on a group of chromatin-associated proteins that specifically recognize double stranded BURs. Several important proteins have been identified from cancer cells as BUR-binding proteins, including poly (ADP-ribose) polymerase (PARP-1), Ku autoantigen, SAF-A, HMG-I(Y), nucleolin and p53. Many of these proteins are dramatically upregulated in malignancy of the breast. Increase in the amount of these BUR-binding proteins, some of which are known to interact with each other, may not only provide an architectural core but also recruit functional multi-molecular complexes at the base of chromatin loops to affect multiple distant genes. Experimental strategies by which these proteins can be exploited as carcinoma-specific diagnostic markers and as targets for antineoplastic therapy are discussed.
Progress of hard mask material for multi-layer stack application (2007)

Multi-layer stack application will be established at manufacturing process beyond 65nm node. Multi-layer stack application means laminated layer like a Photoresist, Si contained hard mask, and Carbon hard mask on substrate. Multilayer stack application can be solved anti-reflection at hyper NA (that means more than 1 numerical aperture) and less etching resistance in thinner film resist, so Multi-layer stack application is required for 193nm immersion lithography process. And criteria of our material in Multi-stack application are spin-on and drain compatible type. In this report, we will discuss about Spin-on Si-contained hard mask and spin-on carbon hard mask criteria, our experiment and results to solve issue. Spin-on Si-contained hard mask is required 3-factors that is unti-reflection from substrate at hyper NA conditions, resist matching, and higher etching resistance. It is general that higher Si-content ratio in based polymer can't be matched with current 193nm photoresist. But Lower Si-contained Hard Mask can't be resisted by dry etching. In this report, we will discuss about our material approach for good resist matching (no footing issue) without reduction of Si-content ratio, pattern transfer ability by dry etching, and reflectivity simulation results at Hyper-NA condition. LWR issue after dry etching is key factor of Multi-layer stack application. We estimate that composition of based polymer in carbon hard mask material and film density in carbon Hard Mask is relative to LWR issue after dry etching. In this report, we will discus about our material approach for less LWR issue after dry etching.
Auto-Configuration of ACL Policy in Case of Topology Change in Hybrid SDN (2016)

Software-defined networking (SDN) has emerged as a new network architecture, which decouples both the control and management planes from data plane at forwarding devices. However, SDN deployment is not widely adopted due to the budget constraints of organizations. This is because organizations are always reluctant to invest too much budget to establish a new network infrastructure from scratch. One feasible solution is to deploy a limited number of SDN-enabled devices along with traditional (legacy) network devices in the network of an organization by incrementally replacing traditional network by SDN, which is called hybrid SDN (Hybrid SDN) architecture. Network management and control in Hybrid SDN are vital tasks that require significant effort and resources. Manual handling of these tasks is error prone. Whenever network topology changes, network policies (e.g., access control list) configured at the interfaces of forwarding devices (switches/routers) may be violated. That creates severe security threats for the whole network and degrades the network performance. In this paper, we propose a new approach for Hybrid SDN that auto-detects the interfaces of forwarding devices and network policies that are affected due to change in network topology. In the proposed approach, we model network-wide policy and local policy at forwarding device using a three-tuple and a six-tuple, respectively. We compute graph to represent the topology of the network. By using graph difference technique, we detect a possible change in topology. In the case of topology change, we verify policy for updated topology by traversing tree using six-tuple. If there is any violation in policy implementation, then affected interfaces are indicated and policies that need to be configured are also indicated. Then, policies are configured on the updated topology according to specification in an improved way. Simulation results show that our proposed approach enhances the network efficiency in term of successful packet delivery ratio, the ratio of packets that violated the policy and normalized overhead.
Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria (2013)

Several progeroid disorders, including Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (ZMPSTE24 deficiency), arise when a farnesylated and methylated form of prelamin A accumulates at the nuclear envelope. Here, we found that a hypomorphic allele of isoprenylcysteine carboxyl methyltransferase (ICMT) increased body weight, normalized grip strength, and prevented bone fractures and death in Zmpste24-deficient mice. The reduced ICMT activity caused prelamin A mislocalization within the nucleus and triggered prelamin A-dependent activation of AKT-mammalian target of rapamycin (mTOR) signaling, which abolished the premature senescence of Zmpste24-deficient fibroblasts. ICMT inhibition increased AKT-mTOR signaling and proliferation and delayed senescence in human HGPS fibroblasts but did not reduce the levels of misshapen nuclei in mouse and human cells. Thus, targeting ICMT might be useful for treating prelamin A-associated progeroid disorders.