gebhart/patrepeval huggingface dataset:
Un mediateur efficace pour la cooperation scientifique française: le groupement des universites et des grandes écoles de France pour le relations avec L'Amerique Latine (2006)

Creado el 4 de febrero de 1908 por iniciativa de universitarios franceses, la Agrupación de las Universidades y Grandes Escuelas de Francia para las Relaciones con América Latina, demostró su eficiencia tanto para valorar el laboratorio latinoamericano ante los investigadores y docentes de Francia, como para difundir, en América Latina, los métodos, los conocimientos y el pensamiento francés. Entre las dos Guerras Mundiales, América Latina fue para la cooperación universitaria francesa una tierra de misiones y la Agrupación estableció entonces los fundamentos de la cooperación científica francesa para los tiempos futuros: desarrollar las relaciones intelectuales entre Francia y las �Repúblicas hermanas de América Latina� y, tomando en cuenta las potencialidades económicas ofrecidas por los países del subcontinente, establecer una cooperación universitaria fuerte y duradera
Principal curve classifier-a nonlinear approach to pattern classification (2002)

Presents a general nonlinear approach to pattern classification using principal curves. Principal curves are nonparametric, nonlinear generalizations of the first principal component, and may also be regarded as continuous versions of 1-D self-organizing maps. The new classification technique, principal curve classifier (PCC), involves a novel way of computing a principal curve for each class using the class-labeled training data. An unlabeled test point is given the class-label of the principal curve that is closest to it in Euclidean distance. Preliminary experiments comparing the PCC with established classification methods, using selected datasets from the Elena and Proben1 benchmarks, highlight the merits and limitations of this algorithm.
Criminal Law–Searches and Seizures–Individualized Probable Cause Is Necessary to Search Persons Incidentally on Premises Subject to a Warrant Authorized Search (1981)

In the execution of the warrant the person executing the same may reasonably detain to search any person in
Rapid Flow Cytometry–Based Structural Maintenance of Chromosomes 1 (SMC1) Phosphorylation Assay for Identification of Ataxia-Telangiectasia Homozygotes and Heterozygotes (2009)

The FC-pSMC1 assay shortens the turnaround time for diagnosing A-T homozygotes from approximately 3 months to approximately 3 h. It also identifies A-T heterozygotes and can be used for prenatal counseling or for screening individuals in large study cohorts for potential ATM heterozygosity, which can then be confirmed by sequencing.
Nuclear Stress Bodies (2010)

Nuclear stress bodies (nSBs) are unique subnuclear organelles which form in response to heat shock. They are initiated through a direct interaction between heat shock transcription factor 1 (HSF1) and pericentric tandem repeats of satellite III sequences and correspond to active transcription sites for noncoding satellite III transcripts. Given their unusual features, nSBs are distinct from other known transcription sites. In stressed cells, they are thought to participate in rapid, transient, and global reprogramming of gene expression through different types of mechanisms including chromatin remodeling and trapping of transcription and splicing factors. The analysis of these atypical and intriguing structures uncovers new facets of the relationship between nuclear organization and nuclear function.
Free-space microwave-power transmission (1976)

Laboratory-scale wireless transmission of microwave power approaches fifty-four percent efficiency. DC is converted to a 2.45-GHz signal and is transmitted through horn antenna array; microwave signal is received at rectenna and is simultaneously collected and rectified back to dc at receiving sites; dc is then processed for wired distribution.
The clinical development of FLT3 inhibitors in acute myeloid leukemia (2011)

Clinical responses to several of the early multi-targeted agents were hindered by unfavorable pharmacokinetics and lack of potency. Newer, more potent FLT3 inhibitors such as sorafenib and AC220 possess the ability to achieve more sustained in vivo inhibition of FLT3 and have shown highly promising activity in early clinical studies. As these agents enter advanced stage trials, they carry the potential to make a major clinical impact in this disease. In future, FLT3 inhibitors may be effectively used in combination with other molecularly targeted agents.
Highly Potent Naphthofuran‐Based Retinoic Acid Receptor Agonists (2009)

A collection of arotinoids with a central benzofuran or naphthofuran ring structure was efficiently synthesized by a three-step process that comprises a Sonogashira coupling, an iodine-induced 5-endo-dig cyclization of the o-methoxyphenyl- or naphthyl-ethynyl benzoates, and finally a Suzuki/Sonogashira coupling of the corresponding 3-iodobenzo- or naphthofurans. Most of these 3-substituted naphthofuran arotinoids (but not the 5,7-di-tert-butylbenzofurans with the same substitution pattern at the C2 and C3 positions) are potent agonists of the retinoic acid receptor (RAR) subtypes, with activities in the nanomolar range.
Long-Term CD4 Th1 and Th2 Memory following Acute Lymphocytic Choriomeningitis Virus Infection (1998)

CD4 T cells play a central role in viral immunity. They provide help for B cells and CD8 T cells and can act as effectors themselves. Despite their importance, relatively little is known about the magnitude and duration of virus-specific CD4 T-cell responses. In particular, it is not known whether both CD4 Th1 memory and CD4 Th2 memory can be induced by viral infections. To address these issues, we quantitated virus-specific CD4 Th1 (interleukin 2 [IL-2] and gamma-interferon) and Th2 (IL-4) responses in mice acutely infected with lymphocytic choriomeningitis virus (LCMV). Using two sensitive assays (enzyme-linked immunospot assay and intracellular stain) to measure cytokine production at the single-cell level, we found that both CD4 Th1 and Th2 responses were induced during primary LCMV infection. At the peak (day 8) of the response, the frequency of LCMV-specific CD4 Th1 cells was 1/35 to 1/160 CD4 T cells, and the frequency of Th2 cells was 1/400. After viral clearance, the numbers of virus-specific CD4 T cells dropped to 1/260 to 1/3,700 and then were maintained at this level indefinitely. Upon rechallenge with LCMV, both CD4 Th1 and Th2 memory cells made an anamnestic response in vivo. These results show that unlike some microbial infections in which only Th1 or Th2 responses are seen, an acute viral infection can induce a mixed CD4 T-cell response with long-term memory.
Dominant-negative mutants of a platelet-derived growth factor gene. (1990)

Using site-directed mutagenesis of a PDGF-A cDNA clone, we identify two domains that are required to generate stable, mitogenically active PDGF-AA homodimers. Alteration of the tetra-basic amino acid sequence (Arg84-Arg-Lys-Arg to Arg-Ser-Asn-Gly) results in the formation of stable pro-PDGF-A homodimers that lack mitogenic activity. Substitution of serine for Cys129 destabilizes PDGF-A subunits within the cell. Genes incorporating either the processing lesion or the cysteine substitution suppress wild-type PDGF-A gene expression in a trans-dominant fashion. Suppression occurs because the mutant PDGF subunits dimerize with wild-type subunits to form inactive or unstable heterodimers. Suppression is exerted across phylogenetic boundaries; thus, the mouse PDGF-A chain mutants inhibit the activity of the wild-type Xenopus PDGF-A. The cysteine mutant gene suppresses expression of PDGF-B (c-sis), as well as PDGF-A. The processing mutant gene, however, suppresses only PDGF-A. Dominant-negative mutations of PDGF and other growth factors which, like PDGF, function as dimers may prove useful for creating animals models of growth factor deficiency disease states and for revealing the function of growth factors during early embryonic development.
A handheld laser scanning confocal reflectance imaging–confocal Raman microspectroscopy system (2012)

Confocal reflectance microscopy and confocal Raman spectroscopy have shown potential for non-destructive analysis of samples at micron-scale resolutions. Current studies utilizing these techniques often employ large bench-top microscopes, and are not suited for use outside of laboratory settings. We have developed a microscope which combines laser scanning confocal reflectance imaging and confocal Raman spectroscopy into a compact handheld probe that is capable of high-resolution imaging and spectroscopy in a variety of settings. The compact size of the probe is largely due to the use of a MEMS mirror for beam scanning. The probe is capable of axial resolutions of up to 4 μm for the confocal imaging channel and 10 μm for the confocal Raman spectroscopy channel. Here, we report instrument design, characterize optical performance, and provide images and spectra from normal skin to demonstrate the instrument's capabilities for clinical diagnostics.
Autoimmune disorders, physical activity, and training, with particular reference to rheumatoid arthritis. (1997)

Rheumatoid arthritis arises from a reaction of the immune system to normal body components, sometimes triggered by bacterial or viral infection. The synovia of affected joints are infiltrated by CD4+, CD19-, and plasma cells. The synovial fluid shows a sterile inflammation, with high neutrophil counts and increased concentrations of proinflammatory cytokines (particularly IL-1, IL-8, TNF-alpha and JFN-gamma). The plasma shows increased CD4+ counts and a pro-inflammatory shift in T cell populations with high titers of rheumatoid factors. Traditional treatment has included rest of the affected part, which can cause a reduction of physical condition. However, exercise induces changes in circulating immune function (including a decrease of CD4+ count) that would appear helpful in regulating inflammation. Further, there is evidence that patients can tolerate a program of regular moderate aerobic exercise. Moreover, empirical data suggest that such a prescription substantially enhances physical performance, without exacerbating either clinical or immunological markers of the disease process.
Sabadilla, Schoenocaulon Spp., with Reference to its Toxicity to Houseflies1 (1944)

Journal Article Sabadilla, Schoenocaulon Spp., with Reference to its Toxicity to Houseflies Get access T. C. Allen, T. C. Allen University of Wisconsin, Madison Search for other works by this author on: Oxford Academic PubMed Google Scholar R. J. Dicke, R. J. Dicke University of Wisconsin, Madison Search for other works by this author on: Oxford Academic PubMed Google Scholar H. H. Harris H. H. Harris University of Wisconsin, Madison Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 37, Issue 3, 1 June 1944, Pages 400–408, https://doi.org/10.1093/jee/37.3.400 Published: 01 June 1944
Directed Differentiation of Size‐Controlled Embryoid Bodies Towards Endothelial and Cardiac Lineages in RGD‐Modified Poly(Ethylene Glycol) Hydrogels (2012)

Recent advances in stem cell research have demonstrated the importance of microenvironmental cues in directing stem cell fate towards specific cell lineages. For instance, the size of the embryoid body (EB) was shown to play a role in stem cell differentiation. Other studies have used cell adhesive RGD peptides to direct stem cell fate towards endothelial cells. In this study, materials and cell-based approaches are combined by using microwell arrays to produce size-controlled EBs and encapsulating the resulting aggregates in high molecular weight PEG-4 arm acrylate with and without conjugated RGD to study their effect on stem cell differentiation in a 3D microenvironment. Increasing EB size is observed along with a decrease in the total number of EBs in pristine PEG hydrogel, regardless of the initial EB size. In correlation with this aggregation, EBs in PEG show enhanced cardiogenic differentiation compared to RGD-PEG hydrogel. Both aggregation and cardiogenic differentiation are significantly reduced when RGD peptides are introduced to the microenvironment, while endothelial cell differentiation is accelerated by 3 to 5 days, depending on the EB size, and doubled over the course of cell culture for both EB sizes. Presented results indicate that RGD sequence has a dominant effect in driving endothelial cell differentiation in size-controlled EBs, while pristine multi-arm, high molecular weight PEG can induce cardiogenic differentiation, possibly through EB aggregation. The photopatternable nature of the hydrogel used in this study enabled patterning of such domains devoid or abundant of cell attachment sequences. Therefore, these hydrogels can potentially be used for spatially patterned embryonic stem cell differentiation, which may be beneficial for tissue engineering and regenerative medicine applications.
Interconversion of androst-16-ene steroids by human axillary aerobic coryneform bacteria (1989)

Conference Article| December 01 1989 Interconversion of androst-16-ene steroids by human axillary aerobic coryneform bacteria P. J. RENNIE; P. J. RENNIE *Department of Microbiology, University of Leeds, Leeds LS2 9JT and London SE1 9RT, U.K. Search for other works by this author on: This Site PubMed Google Scholar K. T. HOLLAND; K. T. HOLLAND *Department of Microbiology, University of Leeds, Leeds LS2 9JT and London SE1 9RT, U.K. Search for other works by this author on: This Site PubMed Google Scholar A. I. MALLET; A. I. MALLET †Department of RInstitute of Dermatology and Biochemistry, United Medical and Dental Schools (Guy's and St Thomas's Hospitals), London SE1 9RT, U.K. Search for other works by this author on: This Site PubMed Google Scholar W. J. WATKINS; W. J. WATKINS ‡Division of Biochemistry, United Medical and Dental Schools (Guy's and St Thomas's Hospitals), London SE1 9RT, U.K. Search for other works by this author on: This Site PubMed Google Scholar D. B. GOWER D. B. GOWER § ‡Division of Biochemistry, United Medical and Dental Schools (Guy's and St Thomas's Hospitals), London SE1 9RT, U.K. §To whom correspondence should be addressed Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1989) 17 (6): 1027–1028. https://doi.org/10.1042/bst0171027a Article history Received: June 13 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation P. J. RENNIE, K. T. HOLLAND, A. I. MALLET, W. J. WATKINS, D. B. GOWER; Interconversion of androst-16-ene steroids by human axillary aerobic coryneform bacteria. Biochem Soc Trans 1 December 1989; 17 (6): 1027–1028. doi: https://doi.org/10.1042/bst0171027a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: UAO, underarm odour, PFB, pentafluorobenzyl, TBDMS, t-butyldimethylsilyl This content is only available as a PDF. © 1989 Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Resolution and assignment of absolute configuration to the enantiomers of anastrephin and epianastrephin and their analogs (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTResolution and assignment of absolute configuration to the enantiomers of anastrephin and epianastrephin and their analogsLucjan Strekowski, Melean Visnick, and Merle A. BattisteCite this: J. Org. Chem. 1986, 51, 25, 4836–4839Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/jo00375a016https://doi.org/10.1021/jo00375a016research-articleACS PublicationsRequest reuse permissionsArticle Views588Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bortezomib and Thalidomide, a Steroid Free Regimen in Newly Diagnosed Patients with Multiple Myeloma. (2009)

Abstract Abstract 2867 Poster Board II-843 Corticosteroids have historically been the backbone of most myeloma targeted therapies. However, they are often the major cause of toxicities, especially in elderly patients. In recent years, novel agents such as bortezomib and thalidomide have demonstrated significant anti-myeloma activity with increased overall response rates. We thus designed a study combining these two agents in a steroid-free regimen. Bortezomib (B) and thalidomide (T) were examined as first line treatment in 27 patients with symptomatic multiple myeloma between September 2004 and September 2006. Patients received B 1.3 mg/m2 on days 1, 4, 8 and 11 every 21 days and T 150 mg daily for a maximum of 8 cycles. The overall response rate was 81.5%, with a near CR or greater of 25.8% and a CR (immunofixation negative) of 11%. A major response identified by greater than 90% reduction in the paraprotein was seen in 33% of the patients. Responses were rapid: median time to first response was 36.5 days (range, 14-101 days) and median time to best response was 61 days (range, 16-171 days). The most common grade 3 toxicities were peripheral neuropathy (22%), pneumonia (15%) and fatigue (7%). The only grade 3 hematologic toxicity was anemia (7%). No grade 4 toxicities were seen. 3 patients had mild peripheral neuropathy (PN) at baseline. PN was the most common reason for dose reduction with an average B dose of 1.1mg/m2 and T of 110mg daily. The major cause of discontinuation of treatment was PN. The PN completely resolved in 80% of the patients upon completion of therapy. No venous thromboembolic events (VTE) were observed even in the absence of prophylactic anticoagulation. It should be noted that upon completion of the study all patients received either B or T maintenance and no patients proceeded onto stem cell transplant immediately. The median progression free survival (PFS) was 16.8 months (95% CI 8.7-21.6 months). Median overall survival has not yet been reached at a median follow up of 39 months. The 3 year overall survival is 74%. This study demonstrates: 1) the excellent efficacy of a steroid-free regimen; 2) good PFS in the absence of stem cell transplantation; and 3) that most treatment-related PN resolves. Disclosures: Huff: Celgene: Consultancy. Borrello:Celgene: Speakers Bureau; Mellenium: Consultancy.
A Phase I and Pharmacokinetic Study of Lapatinib in Combination with Letrozole in Patients with Advanced Cancer (2008)

Clinically relevant doses of lapatinib in combination with letrozole were well tolerated and did not result in a pharmacokinetic interaction, and clinical antitumor activity was observed.
Integrated Inertial Navigation System/Global Positioning System (INS/GPS) for automatic space return vehicle (2002)

A digital GN&C system that automatically returns a space vehicle from orbit to a precision touchdown/landing is described. It is demonstrated that a capsule or lifting body manned return vehicle (MRV) with integrated INS/GPS (inertial navigation system/global positioning system) provides a highly autonomous and automatic deorbit, entry, and precision landing capability. Simulation results are used to demonstrate automatic MRV landing feasibility using absolute GPS for a vertically landing capsule vehicle and the feasibility of using integrated differential GPS/INS to provide the accuracy for a lifting body to perform a safe runway landing without needing TACAN (tactical air navigation) or microwave landing system (MLS) navigational aids. Testing of an advanced system using differential GPS/INS is expected to provide an extensive database on GPS/INS system accuracies and to demonstrate a lower cost alternative to TACAN, DME (distance measuring equipment), and MLS navigation aids.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Can't you hear me knocking: Identification of user actions on Android apps via traffic analysis (2014)

While smartphone usage become more and more pervasive, people start also asking to which extent such devices can be maliciously exploited as "tracking devices". The concern is not only related to an adversary taking physical or remote control of the device (e.g., via a malicious app), but also to what a passive adversary (without the above capabilities) can observe from the device communications. Work in this latter direction aimed, for example, at inferring the apps a user has installed on his device, or identifying the presence of a specific user within a network. In this paper, we move a step forward: we investigate to which extent it is feasible to identify the specific actions that a user is doing on his mobile device, by simply eavesdropping the device's network traffic. In particular, we aim at identifying actions like browsing someone's profile on a social network, posting a message on a friend's wall, or sending an email. We design a system that achieves this goal starting from encrypted TCP/IP packets: it works through identification of network flows and application of machine learning techniques. We did a complete implementation of this system and run a thorough set of experiments, which show that it can achieve accuracy and precision higher than 95%, for most of the considered actions.
Na+, K+, and H+/HCO3− Transport in Submandibular Salivary Ducts (1995)

The mechanisms mediating transepithelial ion transport in salivary ducts were characterized and localized by studying the regulation of [Na+]i, [K+]i, and pHi in isolated intralobular ducts and perfused main ducts of the submandibular salivary gland. A new procedure was developed for the rapid preparation of intralobular ducts. Measurements of pHi revealed the presence of Na+/H+ and Cl-/HCO3- exchange activities in intralobular duct cells. We could not obtain evidence for a coupled K+/H+ exchange activity which was postulated to exist in the luminal membrane of duct cells. Rather, a Kout+-dependent pathway which mediates the transport of H+/HCO3- and Na+ was found. This pathway was absent from acinar cells of the same gland and was active in unstimulated duct cells incubated in 5mM Kout+. Accordingly, inhibition of the Na+ pump with ouabain resulted in rapid and large Na+ influx in duct but not acinar cells. Perfusion experiments with the experimentally accessible main duct and measurements of pHi were used to provide the first direct localization of ion transporters in salivary ducts. The luminal and basolateral membranes of the duct express separate Na+/N+ and Cl-/HCO3- exchangers. Na+/H+ exchange activity in both membranes was similar, whereas the luminal Cl-/HCO3- exchange activity was higher than that in the basolateral membrane. The perfused main dust was also used to localize the newly discovered Kout(+)-dependent H+/HCO3- and Na+ transport pathway to the luminal membrane, which suggests that this pathway may play an important role in Na+ reabsorption of K+ and HCO3- secretion by the salivary ductal system.