gebhart/patrepeval huggingface dataset:
Biochemical regulation of adenylate cyclase in murine melanoma clones with different metastatic properties (1986)

The regulation of adenylate cyclase in murine melanoma tumor cell clones with different metastatic capacities has been studied in intact cells and isolated membrane preparations. Analysis of the responses of intact cells from a number of B16 melanoma clones revealed that treatment with melanocyte-stimulating hormone (MSH) or the diterpene, forskolin, produced significantly greater accumulation of intracellular cyclic adenosine 3',5' monophosphate (cAMP) in strongly metastatic clones than in weakly metastatic tumor cell clones. In contrast, in isolated membranes from the same panel of clones, the extent of activation by forskolin but not by MSH correlated with metastatic capacity. Sodium fluoride and 5'-guanyl-beta-gamma-imidodiphosphate [Gpp(NH)p] also stimulated adenylate cyclase in isolated membranes but the extent of activation did not correlate with the metastatic behavior of the donor cells. A combination of forskolin and Gpp(NH)p proved to be a sensitive prospective indicator for identifying differences in the metastatic capabilities of individual B16 melanoma clones. Adenylate cyclase in membrane preparations from strongly metastatic B16 clones displayed synergistic activation but stimulation of the enzyme from weakly metastatic clones was less than additive. To test the generality of these findings, similar investigations were performed on B16-BL6 melanoma cells, a highly invasive subline of the B16 melanoma, and the K1735, an ultraviolet-light-induced murine melanoma arising in a different mouse strain (C3H). Consistent with their high metastatic potential, clones derived from the B16-BL6 melanoma displayed elevated levels of hormonally-stimulated adenylate cyclase, thereby confirming, for this tumor system, a close association between hormonal responsiveness and metastatic capacity. In contrast, K1735 melanoma cell clones exhibited significant interclonal variation in adenylate cyclase activity and metastatic performance, but no consistent relationship between the two traits was detected. Differences in the regulation and/or the intrinsic catalytic capacity of adenylate cyclase may account, at least in part, for the variation in hormonal responsiveness observed among B16 clones with distinct metastatic properties and suggest that cAMP-dependent molecular processes may be required for the expression of B16 melanoma experimental metastatic potential.(ABSTRACT TRUNCATED AT 400 WORDS)
Postoperative fibrosis after surgical treatment of the porcine spinal cord: a comparison of dural substitutes (2005)

The DuraGen dural substitute produced the least amount of inflammation in the subarachnoid space and Preclude generated the most (p < 0.001). Surgicel and DuraGen were completely resorbed on histological sections, but both produced some inflammation, which diminished gradually from the dural implant center. Histological evaluation of the nonresorbed grafts demonstrated that Durasis caused the least degree of inflammatory cell infiltration (p < 0.001). The Preclude dural substitute consistently demonstrated encapsulation and arachnoidal reaction. There was no evidence of implant-related adverse effects on the underlying pia mater and white matter regardless of the substitute type.
Quantified risk-adaptive access control for patient privacy protection in health information systems (2011)

In traditional access control systems, security administrators determine whether an information consumer can access a certain resource. However, in reality, it is very difficult for policy makers to foresee what information a user may need in various situations. In hospitals, failing to authorize a doctor for the medical information she needs about a patient could lead to severe or fatal consequences. In this paper, we propose a practical access control approach to protect patient privacy in health information systems by taking the realities in healthcare into consideration. First, unlike traditional access control systems, our proposed access control model allows information consumers (i.e. doctors) to make access decisions, while still being able to detect and control the over-accessing of patients' medical data by quantifying the risk associated with doctors' data-accessing activities. Second, we do not require doctors to do anything special in order to use our system. We learn about common practices among doctors and apply statistical methods and information theory techniques to quantify the risk of privacy violation. Third, occasional exceptions on information needs, which is common in healthcare, is taken into account in our model. We have implemented a prototype of our solution and performed simulations on real-world medical history records.
Environmental tobacco smoke in the workplace induces oxidative stress in employees, including increased production of 8-hydroxy-2'-deoxyguanosine. (1998)

Environmental tobacco smoke (ETS) is a pervasive contaminant in the workplace. Our objective was to determine the oxidative stress effects of ETS on employees who are exposed. The results provide information that is useful to the resolution of risk assessment questions associated with ETS. We analyzed two blood draws from volunteers in our control and exposed groups. The level of exposure to ETS was determined through plasma cotinine measurements, which showed a 65% increase from the control group to the exposed group. Exposure to ETS resulted in a statistically significant increase of 63% of the oxidative DNA mutagen 8-hydroxy-2'-deoxyguanosine in the blood of exposed subjects. This oxidative DNA damage has been linked to an increased risk of developing several degenerative chronic diseases, including coronary heart disease and cancer. The exposed subjects also had increased levels of superoxide dismutase, catalase, glutathione peroxidase (GPOX), and glutathione reductase. However, these increases were only statistically significant in catalase and GPOX. Catalase levels were 13% higher in the exposed group, and GPOX levels were 37% higher in exposed volunteers. The biochemical evidence suggests that exposure to ETS causes oxidative stress, resulting in DNA damage that may increase the risk of certain diseases.
Association of hydrophobic counterions in aqueous solution of poly(allylammonium) chloride: Comparison between <i>p</i>‐<i>n</i>‐propylbenzenesulfonate and <i>p</i>‐iso‐propylbenzenesulfonate ions (1994)

Abstract The hydrophobic association behavior of p ‐propylbenzenesulfonate ions ( n ‐PBS − and iso‐PBS − ) around poly(allylammonium) cation (PAAH + was studied by absorption and 1 H nuclear magnetic resonance (NMR) spectroscopy. In the presence of PAAH + Cl − , the broadening (hypochromism) of absorption band of PBS − were observed. In addition, all 1 H NMR signals of PBS − exhibited up‐field shift which resulted from the intermolecular ring current shift. These results indicate the hydrophobic association of negative PBS − around PAAH + . The hydrophobic association arises from the accumulation of counterions around the polyion, and is stabilized by the hydrophobic interaction between propyl groups and the stacking interaction between benzene rings. The association of iso‐PBS − ions is rather weaker than that of n ‐PBS − , suggesting that the steric hindrance of isopropyl groups prevents an effective association of hydrophobic counterions. Furthermore, through viscosity and Cl − activity measurements, it was found that the binding of associated PBS − ,s to PAAH + causes the change of its surroundings to hydrophobic character and its conformation. © 1994 John Wiley & Sons, Inc.
Hepatic Binding Protein: The Protective Role of Its Sialic Acid Residues (1977)

Removal of sialic acid from a specific hepatic binding protein virtually abolishes its capacity to bind certain asialoglycoproteins. The loss of this capacity is the result of competition for the binding sites by galactosyl residues, of hepatic binding protein, that become terminal after desialylation.
Effective performance measurement and analysis of multithreaded applications (2009)

Understanding why the performance of a multithreaded program does not improve linearly with the number of cores in a shared-memory node populated with one or more multicore processors is a problem of growing practical importance. This paper makes three contributions to performance analysis of multithreaded programs. First, we describe how to measure and attribute parallel idleness, namely, where threads are stalled and unable to work. This technique applies broadly to programming models ranging from explicit threading (e.g., Pthreads) to higher-level models such as Cilk and OpenMP. Second, we describe how to measure and attribute parallel overhead -- when a thread is performing miscellaneous work other than executing the user's computation. By employing a combination of compiler support and post-mortem analysis, we incur no measurement cost beyond normal profiling to glean this information. Using idleness and overhead metrics enables one to pinpoint areas of an application where concurrency should be increased (to reduce idleness), decreased (to reduce overhead), or where the present parallelization is hopeless (where idleness and overhead are both high). Third, we describe how to measure and attribute arbitrary performance metrics for high-level multithreaded programming models, such as Cilk. This requires bridging the gap between the expression of logical concurrency in programs and its realization at run-time as it is adaptively partitioned and scheduled onto a pool of threads. We have prototyped these ideas in the context of Rice University's HPCToolkit performance tools. We describe our approach, implementation, and experiences applying this approach to measure and attribute work, idleness, and overhead in executions of Cilk programs.
Structure and synthesis of 25-hydroxycholecalciferol-26,23-lactone, a metabolite of vitamin D (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and synthesis of 25-hydroxycholecalciferol-26,23-lactone, a metabolite of vitamin DDavid S. Morris, Dudley H. Williams, and Alan F. NorrisCite this: J. Org. Chem. 1981, 46, 17, 3422–3428Publication Date (Print):August 1, 1981Publication History Published online1 May 2002Published inissue 1 August 1981https://pubs.acs.org/doi/10.1021/jo00330a007https://doi.org/10.1021/jo00330a007research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Flow Shear Stress Enhances the Proliferative Potential of Cultured Radial Glial Cells Possibly Via an Activation of Mechanosensitive Calcium Channel (2017)

Radial glial cells (RGCs) which function as neural stem cells are known to be non-excitable and their proliferation depends on the intracellular calcium (Ca<sup>2+</sup>) level. It has been well established that Inositol 1,4,5-trisphosphate (IP<sub>3</sub>)-mediated Ca<sup>2+</sup> release and Ca<sup>2+</sup> entry through various Ca<sup>2+</sup> channels are involved in the proliferation of RGCs. Furthermore, RGCs line the ventricular wall and are exposed to a shear stress due to a physical contact with the cerebrospinal fluid (CSF). However, little is known about how the Ca<sup>2+</sup> entry through mechanosensitive ion channels affects the proliferation of RGCs. Hence, we hypothesized that shear stress due to a flow of CSF boosts the proliferative potential of RGCs possibly via an activation of mechanosensitive Ca<sup>2+</sup> channel during the embryonic brain development. Here, we developed a new microfluidic two-dimensional culture system to establish a link between the flow shear stress and the proliferative activity of cultured RGCs. Using this microfluidic device, we successfully visualized the artificial CSF and RGCs in direct contact and found a significant enhancement of proliferative capacity of RGCs in response to increased shear stress. To determine if there are any mechanosensitive ion channels involved, a mechanical stimulation by poking was given to individual RGCs. We found that a poking on radial glial cell induced an increase in intracellular Ca<sup>2+</sup> level, which disappeared under the extracellular Ca<sup>2+</sup>-free condition. Our results suggest that the shear stress by CSF flow possibly activates mechanosensitive Ca<sup>2+</sup> channels, which gives rise to a Ca<sup>2+</sup> entry which enhances the proliferative capacity of RGCs.
<title>Evaluation of a fast and flexible OPC package: OPTISSIMO</title> (1996)

It is out of question, that current state-of-the-art lithography--printing 350 nm structures with i-line tools or 250 nm structures with DUV tools--needs to correct for proximity effects (OPC). Otherwise, all the well-known effects like line-end shortening, linewidth variation as a function of adjacent patterns, linewidth non-linearity, etc. will produce a pattern, that is significantly different from the intended design. In this paper, we report first evaluation results of OPTISSIMO, a software package for automatic proximity correction. Besides the ability to handle full-chip designs by preserving as much as possible of the original data-hierarchy, there are significant options for the user. A large number of choices can be made to balance between the precision of the correction and the complexity of the corrected design. The main target of our evaluations was to check for full-chip OPC for the gate level of a state-of-the-art design. This corresponds to print either linewidths in the 350 nm to 400 nm range with i-line lithography or 250 nm/300 nm linewidth with DUV lithography. Taking 400 nm i-line lithography as an example, 3% precision OPC which has been demonstrated. By using hierarchical data handling, it was shown, that even the data complexity of a 256 M DRAM can be managed within reasonable time.
Social Psychology of Identities (2000)

In this chapter I review the social psychological underpinnings of identity, emphasizing social cognitive and symbolic interactionist perspectives and research, and I turn then to key themes of current work on identity—social psychological, sociological, and interdisciplinary. I emphasize the social bases of identity, particularly identities based on ethnicity, race, sexuality, gender, class, age, and (dis)ability, both separately and as they intersect. I also take up identities based on space, both geographic and virtual. I discuss struggles over identities, organized by social inequalities, nationalisms, and social movements. I conclude by discussing postmodernist conceptions of identities as fluid, multidimensional, personalized social constructions that reflect sociohistorical contexts, approaches remarkably consistent with recent empirical social psychological research, and I argue explicitly for a politicized social psychology of identities that brings together the structures of everyday lives and the sociocultural realities in which those lives are lived. “Identity … is a concept that neither imprisons (as does much in sociology) nor detaches (as does much in philosophy and psychology) persons from their social and symbolic universes, [so] it has over the years retained a generic force that few concepts in our field have.” ( Davis 1991 :105) “[I]dentity is never a priori, nor a finished product; it is only ever the problematic process of access to an image of totality.” ( Bhabha 1994 :51)
Advances in Seismic Imaging — Impact on Exploration through Production in Fractured Basement Reservoir Block 15-1, Offshore Vietnam (2009)

Abstract Block 15-1 is located at the northern end of the Cuu Long Basin off the coast of Vietnam. 5 primary deformation events have effected the Cuu Long Basin. 2 compressive phases occurred in the late Jurassic- early Cretaceous followed by the main rifting phase during the Paleogene. The extension direction orientated NW-SE and is responsible for the NE-striking horst-graben architecture of the Basin. 2 important compressive events were followed in the lake Oligocene and Neogene. Reservoir quality in the basement reservoir is directly linked to the fracture development, which can be highly variable in any given oil field. Regional fracture zones are usually predicted based on the regional tectonic stress field that impacted the basement. Keywords: Su Tu Fields • SuTu Naum SuTu Den • SuTu Vang • SuTu Trang Presented at: 2009 South East Asia Petroleum Exploration Society (SEAPEX) Conference, Singapore, 2009
A Novel Monostable Multivibrator Circuit (2005)

This article represents a novel monostable multivibrator circuit in which width and height of the pulse output can be independent electronically adjusted. In addition, the pulse width of output is not restricted to be wider or narrower than that of input pulse as conventionally employed. Namely, there is no restriction on the width of input and output pulse, the circuit's implementation is thus more convenient. The proposed circuit is composed of three OTAs, two resistors and one capacitor, basically constructed a simple pulse generator (Schmitt-trigger circuit). Therewith the compactness of the circuit, it is thus suitable to be fabricated for integrated circuit. The results of circuit simulation is accordance well with theoretical analysis.
In-source decay and fragmentation characteristics of peptides using 5-aminosalicylic acid as a matrix in matrix-assisted laser desorption/ionization mass spectrometry (2010)

The use of 5-aminosalicylic acid (5-ASA) as a new matrix for in-source decay (ISD) of peptides including mono- and di-phosphorylated peptides in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) is described. The use of 5-ASA in MALDI-ISD has been evaluated from several standpoints: hydrogen-donating ability, the outstanding sharpness of molecular and fragment ion peaks, and the presence of interference peaks such as metastable peaks and multiply charged ions. The hydrogen-donating ability of several matrices such as alpha-cyano-4-hydroxycinnamic acid (CHCA), 2,5-dihydroxybenzoic acid (2,5-DHB), 1,5-diaminonaphthalene (1,5-DAN), sinapinic acid (SA), and 5-ASA was evaluated by using the peak abundance of a reduction product [M + 2H + H](+) to that of non-reduced protonated molecule [M + H](+) of the cyclic peptide vasopressin which contains a disulfide bond (S-S). The order of hydrogen-donating ability was 1,5-DAN > 5-ASA > 2,5-DHB > SA = CHCA. The chemicals 1,5-DAN and 5-ASA in particular can be classified as reductive matrices. 5-ASA gave peaks with higher sharpness for protonated molecules and fragment ions than other matrices and did not give any interference peaks such as multiply-protonated ions and metastable ions in the ISD mass spectra of the peptides used. Particularly, 1,5-DAN and 5-ASA gave very little metastable peaks. This indicates that 1,5-DAN and 5-ASA are more "cool" than other matrices. The 1,5-DAN and 5-ASA can therefore be termed "reductive cool" matrix. Further, it was confirmed that ISD phenomena such as N-Calpha bond cleavage and reduction of S-S bond is a single event in the ion source. The characteristic fragmentations, which form a- and (a + 2)-series ions, [M + H - 15](+), [M + H - 28](+), and [M + H - 44](+) ions in the MALDI-ISD are described.
Use of Doubly Chained Tree Structures in File Organisation for Optimal Searching (1986)

The problem of minimising the search length (time) associated with a variable length, doubly chained tree structure with weighted terminal nodes and its implications on the organisation of a file are investigated. The main result is an algorithm which constructs an optimal doubly chained tree as a static data structure. Also considered are a few ramifications, particularly when the search steps have unequal costs. The supporting activity of file maintenance is also discussed. Two methods of updating a data file organised as a doubly chained tree structures are presented, which allow the realisation of a dynamic data structure.
The present role of estramustine phosphate in advanced prostate cancer. (1991)

With estramustine phosphate the clinician has the possibility to ensure complete hormonal as well as cytotoxic control of advanced prostate cancer with a single drug. EMP is considered as a first choice for treatment of hormone refractory prostate cancer. It is at least as effective as conventional chemotherapy, yet less aggressive with regard to its toxicity profile. EMP is particularly useful in patients with limited bone marrow reserve, e.g. in case of prior or associated radiotherapy. As to the use of EMP in primary treatment, more information is required before we can define with certainty subgroups of patients who would benefit more from an early course of EMP than from other hormonal therapy. The existing data point in the direction of poorly differentiated tumors, patients with bone pain and poor prognosis. EMP treatment is associated with an increased risk of cardiovascular morbidity. This should be avoided as much as possible by proper selection of patients or by prophylaxis. Gastro-intestinal side effects, such as nausea, diarrhea and anorexia are dose-dependent. These adverse events tend to interfere with compliance at dosages over 560 mg/day. Dosage modifications or an anti-emetic may help. The intravenous administration of EMP offers the possibility for high loading doses at a substantially reduced risk for cardiovascular and gastrointestinal side effects.