gebhart/patrepeval huggingface dataset:
Serum Leucine Aminopeptidase for Monitoring ViralInfections with Plasmacytoid Reaction (1986)

Analysis of data on 9 cases with active cytomegalovirus infection in patients with kidney grafts showed a positive association of serum leucine aminopeptidase activity concentration with the appearance of plasmacytoid lymphocytes in blood. Additional studies indicate that like the liver, the lymphocytes contain leucine aminopeptidase in relatively large quantities and that this enzyme is increased about 3-fold in plasmacytoid lymphocytes when compared with the activity in normal lymphocytes. In contrast, the 'hepatic' enzyme alanine aminotransferase is practically absent in both lymphocytes and plasmacytoid cells. Therefore, the difference in serum between the relative increases of leucine aminopeptidase and alanine aminotransferase may be attributed to proliferating plasmacytoid lymphocytes. Earlier observations on a large number of cases of acute viral hepatitis A or B lend credence to this assumption. However, in this disease, the serum enzyme changes reflect the much greater involvement of the liver and the relatively slight, but significant, proliferation of plasmacytoid lymphocytes. Our hypothesis is confirmed by the recent observation of 3 cases of acute EBV infection (infectious mononucleosis) in otherwise healthy individuals showing greatly elevated leucine aminopeptidase in contrast to normal or slightly raised alanine aminotransferase in serum.
Cyclic AMP-independent Up-regulation of the Human Serotonin Transporter by Staurosporine in Choriocarcinoma Cells (1995)

Treatment of confluent cultures of JAR human placental choriocarcinoma cells with staurosporine caused a marked stimulation of serotonin transport activity in these cells. The stimulatory effect was noticeable at nanomolar concentrations of staurosporine, and a treatment time of > 4 h was required for staurosporine to elicit the effect. At 40 nM and with a treatment time of 16 h, the stimulation of the transport activity was 3.5-6.0-fold. None of the several other protein kinase inhibitors tested had similar effect except KT 5720, a protein kinase A inhibitor, which showed a small but significant (approximately 1.4-fold) stimulatory effect at a concentration of 5 microM. Blockade of RNA synthesis and protein synthesis in the cells prevented completely the stimulation of the transport activity induced by staurosporine. The stimulation was observed not only in intact cells but also in plasma membrane vesicles prepared from staurosporine-treated cells. The stimulation was accompanied by a 5-7-fold increase in the steady state levels of the transporter-specific mRNAs, by a 7-fold increase in the maximal velocity of the transport process, and by a 6-fold increase in the transporter density in the plasma membrane. Even though both staurosporine and cholera toxin had similar effects on the serotonin transport activity in these cells, the effect was not additive when the cells were treated with both reagents together. While treatment of the cells with cholera toxin markedly elevated intracellular levels of cAMP, staurosporine did not have any effect on the cellular levels of this cyclic nucleotide. It is concluded that staurosporine up-regulates the serotonin transport activity in JAR cells by increasing the steady state levels of the serotonin transporter mRNA and by the consequent increase in the transporter density in the plasma membrane and that the process involves a cAMP-independent signaling pathway.
Single Crystal of the Pb(Zn<sub>1/3</sub>Nb<sub>2/3</sub>)O<sub>3</sub>–PbTiO<sub>3</sub> System Grown by the Vertical Bridgeman Method and Its Characterization (1998)

A large single crystal (about 30 mm in diameter by 20 mm long) of the Pb(Zn 1/3 Nb 2/3 )O 3 –PbTiO 3 (PZN–PT) solid solution system was successfully grown using the vertical Bridgeman method and its properties were investigated. No defects such as flux inclusions were observed on as-polished {100} plates, except in a small area near the nucleation point. Further, a domain structure with striped patterning, and an opaque area were observed in the light yellow plate. Distribution of the temperature of transition ( T RT ) from the ferroelectric rhombohedral phase to the tetragonal phase was investigated within the {100} plates. Transition temperatures were found to be scattered in the range of 48°C to 103°C across the area of these plates. Small rectangular samples poled along the [001] direction and cut along the [100] direction from (001) plates containing 9.5 to 10 mol% of PbTiO 3 , and with a transition temperature of T RT =70–90°C, exhibited high electromechanical coupling constants (rectangular bar mode, k 33 ′ >85%) at room temperature.
Optimal Use of Peritoneal Dialysis in Patients with Diabetes (2009)

The survival of patients with end-stage renal disease (ESRD) resulting from diabetes continues to improve, but the survival rate among diabetic ESRD patients remains the lowest among all primary diagnoses probably because of the higher prevalence of cardiovascular comorbidity associated with diabetes. Diabetes, age, and comorbidity all significantly modify the effect of treatment modality on patient survival. As compared with hemodialysis (HD), peritoneal dialysis (PD) offers an equal or lower risk of death across all subgroups during the first 1-2 years of dialysis. The association of PD with better outcomes than are seen with HD is probably a result of a lower prevalence of infections and congestive heart failure and better preservation of residual renal function (RRF) in PD patients. Use of angiotensin converting-enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) helps to preserve RRF in ESRD patients and to maintain peritoneal membrane integrity longer in PD patients. Antioxidants can also support preservation of peritoneal membrane function. Peritoneal dialysis should be the initial modality of dialysis in all ESRD patients. Older patients (age > or = 45 years) with diabetes and patients without diabetes may switch to HD or receive a kidney graft in 1-2 years' time; younger patients (age < 45 years) with diabetes may stay on PD longer. Use of ACEI and ARB or antioxidants can help to maintain peritoneal membrane function longer.
Isothermal Switching and Detailed Filament Evolution in Memristive Systems (2014)

The steady-state solution of filamentary memristive switching may be derived directly from the heat equation, modelling vertical and radial heat flow. This solution is shown to provide a continuous and accurate description of the evolution of the filament radius, composition, heat flow, and temperature during switching, and is shown to apply to a large range of switching materials and experimental time-scales.
Improving the outcome of patients with castration-resistant prostate cancer through rational drug development (2006)

Castration-resistant prostate cancer (CRPC) is now the second most common cause of male cancer-related mortality. Although docetaxel has recently been shown to extend the survival of patients with CRPC in two large randomised phase III studies, subsequent treatment options remain limited for these patients. A greater understanding of the molecular causes of castration resistance is allowing a more rational approach to the development of new drugs and many new agents are now in clinical development. Therapeutic targets include the adrenal steroid synthesis pathway, androgen receptor signalling, the epidermal growth factor receptor family, insulin growth factor-1 receptor, histone deacetylase, heat shock protein 90 and the tumour vasculature. Drugs against these targets are giving an insight into the molecular pathogenesis of this disease and promise to improve patient quality of life and survival. Finally, the recent discovery of chromosomal translocations resulting in the upregulation of one of at least 3 ETS genes (ERG, ETV1, ETV4) may lead to novel agents for the treatment of this disease.
Design of Low-Power Asynchronous MSP430 Processor Core Using AFSM Based Controllers (2008)

As an asynchronous design method, TiDE tool chain supports the robust design flow at a high level with an asynchronous specialized language, HASTE. However, there is a limitation at an optimized step, since it is difficult for designers to know and manage inner synthesis operations. With a button-up manner based on the synthesis method with asynchronous finite state machine (AFSM), we design an asynchronous MSP430 core which is widely used in the sensor nodes. The designed asynchronous MSP430 core was compared with an already designed asynchronous MSP430 core which employed the TiDE tool flow and a clock based synchronous MSP430 core at 0.13 um CMOS technology. The maximum performance of the TiDE tool version was only 40.6 % of the synchronous or the AFSM version. The AFSM version saves the energy consumption of the synchronous version and the TiDE tool version by about 31.9 % and 28.8 %, respectively.
Viral Diseases of Cattle (1981)

Preface to the Second Edition Viruses and Virology Concepts for Studying Viral Infections The Epidemiology of Bovine Viral Inections Diagnostic and Investigative Techniques Vaccines and Vaccination Clinical Manifestations and Differential Diagnosis Disinfectants and Disinfection The Impact of Bovine Viral Diseases on International Trade Adenoviruses Bluetongue Bovine Immunodeficiency-Like Virus (Bovine Lentivirus) Bovine Leukemia Virus and Enzootic Bovine Leukosis Bovine Viral Diarrhea Coronaviruses Enteroviruses Fibropapillomatosis (Warts) and Papillomaviruses Herpes Mammillitis and Pseudo Lumpy Skin Disease Infectious Bovine Rhinotracheitis and Infectious Pustular Vulvovaginitis Malignant Catarrhal Fever Papular Stomatitis Parainfluenza Type-3 Parvoviruses Poxvirus Infections of the Teats Pseudorabies Rabies Respiratory Syncytial Virus Rhinoviruses Rotavirus Associated with Neonatal Diarrhea Vesicular Stomatitis Akabane and Bunyaviruses Causing Fetal Wastage Ephemeral Fever Foot-and-Mouth Disease Lumpy Skin Disease Rift Valley Fever Rinderpest Bovine Spongiform Encephalopathy.
Analysis of 3-D Myocardial Motion in Tagged MR Images Using Nonrigid Image Registration (2004)

Tagged magnetic resonance imaging (MRI) is unique in its ability to noninvasively image the motion and deformation of the heart in vivo, but one of the fundamental reasons limiting its use in the clinical environment is the absence of automated tools to derive clinically useful information from tagged MR images. In this paper, we present a novel and fully automated technique based on nonrigid image registration using multilevel free-form deformations (MFFDs) for the analysis of myocardial motion using tagged MRI. The novel aspect of our technique is its integrated nature for tag localization and deformation field reconstruction using image registration and voxel based similarity measures. To extract the motion field within the myocardium during systole we register a sequence of images taken during systole to a set of reference images taken at end-diastole, maximizing the normalized mutual information between the images. We use both short-axis and long-axis images of the heart to estimate the full four-dimensional motion field within the myocardium. We also present validation results from data acquired from twelve volunteers.
Complexity in simplicity: monogenic disorders and complex cardiomyopathies (1999)

nents of the primary cardiac cytoarchitecture, including components of the cardiac contractile sarcomere, and the intrasarcomeric, and extrasarcomeric cytoskeleton (2, 3, 7). The cytosol of all eukaryotic cells contains a network of protein filaments and associated proteins which collectively constitute the cytoskeleton. Among these filaments are the actin microfilaments, the somewhat wider tubulin microtubules, and the intermediate filaments. To perform force-generating contraction, and to accommodate the repetitive changes in cell geometry that occur during each cardiac cycle, cardiac myocytes have evolved an abundant and highly specialized cytoskeleton, whose components can be classified into the following 3 groups: (a) The force-generating contractile sarcomeric cytoskeleton consists of a highly-ordered arrangement of myosin thick filaments, actin thin filaments, and associated proteins, such as the troponin‐tropomyosin complex. The repeating sarcomere units are arranged in series, resulting in striated myofibrils. (b) The intrasarcomeric cytoskeleton contains titin, α-actinin, myosin binding protein C, and other proteins that anchor myofilaments and their sarcomeric units and regulate the displacement of myofilaments during each contraction cycle. (c) The extrasarcomeric cytoskeleton is composed of desmin and lamin-containing intermediate filaments that provide a link between adjacent myofibrils and a framework for the nuclear envelope. This extrasarcomeric network also includes subsarcolemmal proteins that provide a connection between the peripheral myofibrils to the sarcolemma and to the extracellular matrix. These include the subsarcolemmal proteins dystrophin and its associated glycoproteins which link the sarcomere to the extracellular
A unified construction of perfect polyphase sequences (2002)

Polyphase sequences over N-th complex roots of unity are considered. A sequence is perfect if all its out-of-phase periodic autocorrelation equal zero. Numerous constructions of perfect polyphase sequences (PPS) have been proposed due to their importance in various applications such as pulse compression radar, fast-startup equalization and channel estimation, and spread spectrum multiple access systems. We show that all previous PPS constructions, known to us, can be classified into four classes: (i) generalized Frank sequences due to Kumar, Scholtz and Welch (1985), (ii) generalized chirp-like polyphase sequences due to Popovic (see IEEE Trans. Inform. Theory, vol.IT-38, p.1406, 1992), (iii) Milewski (1983) sequences, and (iv) PPS associated with the general construction of the generalized bent function due to Chung and Kumar (1989). The key result is a unified construction of PPS which includes the above four classes as special cases. Only explicit constructions of PPS are considered.
Antigen-capture enzyme immunoassay for detection of avian influenza virus in turkeys (1993)

A double-antibody sandwich ELISA (DAS-ELISA) was developed for detection of avian influenza virus (AIV) antigen. A monoclonal antibody to the viral nucleoprotein (NP) was used to coat the ELISA plates. A direct DAS-ELISA and an indirect DAS-ELISA were evaluated. In the direct DAS-ELISA, monoclonal antibody to the AIV NP conjugated with horseradish peroxidase was used. The direct DAS-ELISA was evaluated for its sensitivity to detect purified NP; this procedure detected as little as 0.1 ng. In the indirect DAS-ELISA, rabbit NP antibody and horseradish peroxidase-conjugated goat anti-rabbit immunoglobin were used as primary and secondary antibodies, respectively. The indirect DAS-ELISA was evaluated for its ability to detect the AIV antigen in tracheal and cloacal specimens from turkeys inoculated with AIV. Results of indirect DAS-ELISA were compared with those of conventional virus isolation. Percentage agreement between indirect DAS-ELISA and virus isolation in AIV-positive samples was found to be 76.1% and, in AIV-negative samples, it was found to be 82.1%. These results indicate that the DAS-ELISA might be a viable alternative to virus isolation because of its rapidity, compared with virus isolation.
Architectural requirements for multimedia image compression, and a solution based on VLSI hardware accelerator (1994)

A VLSI hardware accelerator is proposed for improving the performance of a class of image compression techniques, used in multimedia applications. First, we introduce the concept of hardware accelerators relative to the environment under consideration. After that, we give a possible classification of image compression techniques, from the architecture requirements point of view, with a focus on a class of techniques for which the improvement is proposed. Finally, we introduce the proposed hardware accelerator solution, analyze the expected performance improvement, and discuss the implementational complexity. In conclusion, we present our plans for future work on the subject.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ZUR KENNTNIS DER ORGANOPHOSPHORVERBINDUNGEN XX (1983)

Abstract Bifunctional aminophosphanes (Et2N)2P-[CH2] n ,-P(NEt2)2 (n = 1–10) (1) and Et2NP(R)-[CH2] n -P(R)NEt2 (n = 2–4, R = Alkyl, Ph) (2), which are valuable intermediates in organophosphorus synthesis, are obtained by two methods. Because of the marked nucleophility of phosphorus in 1 and 2, reactions with Lewis acids take place very smoothly as is shown by preparation of (Et2N)2P(X)-[CH2]4-(X)P(NEt2) 2(X = O, S, Se, Te, BH3, BBr3) and [(Et2N)2P(CH3)-[CH2]4-(CH3)P(NEt2)2]2+2r. Fission of P[sbnd]bonds by PCl3, MeOH, H2S and CS2 affords Cl2P-[CH2]4-PCl2, (MeO)2P-[CH2]4-P(OMe)2, (MeO)Et2NP-[CH2]4-PNEt2(OMe), the dithiophosphinate [S2P(H)-[CH2]4-(H)PS2]2-2 Et2NH+ 2, and the dithiocarbaminate [Et2NCS2]2P-[CH2]4-P[S] Die Darstellung der bifunktionellen Aminophosphane (Et2N)2P-[CH2] n -P(NEt2)2 (n = 1−10) (1) und Et2N(R)P-[CH2] n -(R)PNEt2 (n = 2–4, R = Alkyl, Ph) (2), die sich als nützliche Zwischenprodukte bei phosphororganischen Synthesen erwiesen, erfolgte nach zwei Verfahren. Wegen der ausgeprägten Nucleophilie des Phosphors in diesen Verbindungen verlaufen ihre Reaktionen mit Lewissäuren äuβerst glatt, wie am Beispiel der Darstellung von (Et2N)2P(X)-[CH2]4-(X)P(NEt2)2 (X [dbnd] O, S, Se, Te, BH3, BBr3) und [(Et2N)2P(CH3)-[CH2]4-(CH3)P(NEt2)2]2+2I− gezeigt wird. PCl3, MeOH, H2S und CS2 bewirken eine Spaltung der PN-Bindungen unter Bildung von Cl2P-[CH2]4-PCl2, (MeO)2P-[CH2]4-P(OMe)2, (MeO)Et2NP-[CH2]4-PNEt2(OMe), Dithiophosphinat [S2P(H)-[CH2][4-2 CNEt2]2. The 31P{1H}NMR-Spectra are discussed especially with regard to steric aspects in the synthesis of the chiral compounds 2 and their derivatives.(H)PS2]2-2Et2NH+ 2 und Dithiocar-baminat [Et2NCS2]2P-[CH2]4-P[S2CNEt2]2. Die 31P{1H}-NMR-Spektren werden diskutiert, insbesondere im Hinblick auf sterische Aspekte bei der Synthese von chiralen Phosphanen 2 und ihrer Derivate.
Land use and land cover change in Ameleke Watershed, South Ethiopia (2014)

This study investigated the land use and land cover change at Ameleke watershed, middle catchment of Gidabo River, South Ethiopia that occurred from 1986-2006. Landsat TM of 1986, Landsat ETM+ of 2000 and SPOT of 2006 were used to produce land use and land cover maps of the watershed. A pixel-based supervised image classification through decision rule of maximum likelihood classifier algorithm was used to map land use and land covers on ERDAS Imagine 8.6.  For land use and land cover maps of 1986, 2000 and 2006, error matrixes were produced and have an accuracy assessment of 80%, 85% and 85.71% respectively. Focused group discussions and key informant interviews were also used for land use and land cover reconstruction. The result showed from 1986 up to 2006, cropland and mixed cover increased from 23.33% to 31% and 7.26 to 15.68% of the watershed respectively. In contrast grass lands and shrub lands decreased from 25.9% to 14.96% and 30.3% and 24.25% of the watershed respectively in 1986 to 2006. There was also an increasing trend on agroforestry while there was a decreasing trend on riverine forests. This study recommends further assessment and monitoring of spatial and temporal based land use and land cover change at homestead level having high resolution satellite images. Keywords : land use and land cover change, Ameleke watershed
High-Resolution Imaging Spectrometer (1990)

Earth resources observed in greater detail. High-Resolution Imaging Spectrometer, undergoing development for use in NASA's Earth Observing System, measures reflectance of Earth's surface in visible and near-infrared wavelengths. From an orbit around Earth, instrument scans surface of Earth in 200 wavelength bands simultaneously. Produces images enabling identification of minerals in rocks and soils, important algal pigments in oceans and inland waters, changes in spectra associated with biochemistry of plant canopies, compositions of atmospheric aerosols, sizes of grains in snow, and contamination of snow by impurities that absorb visible light.
Study of poly(St/BA/MAA) copolymer latexes with bimodal particle size distribution (1998)

Polymer latexes with bi-modal particle size distribution were prepared by introducing small amount of a second seed of polymer particles during the semicontinuous emulsion polymerization of styrene, butyl acrylate and methacrylic acid. The polymerization was investigated by following the variation of the particle size, the size distribution, the number of particles, the surface tension and surfactant surface coverage at different stages of the polymerization process. The results showed that both the size and size distribution can be controlled by the amount of second polymer particles. The amount of small particles and the partition of monomers consumed for the growth of small particles increased with increasing amount of second polymer particles. It was also demonstrated that small particles grew more quickly than the large ones, but to a limited extent. An introduction of small amount of additional surfactants had no significant effect on the particle size and size distribution of both types of particles. Copyright © 1998 John Wiley & Sons, Ltd.
The status of the name Myotis subulatus Say (1968)

(Uploaded by Plazi for the Bat Literature Project) No abstract provided.
Particle Filter Tracking without Dynamics (2007)

People tracking is an interesting topic in computer vision. It has applications in industrial areas such as surveillance or human‐machine interaction. Particle Filters is a common algorithm for people tracking; challenging situations occur when the target′s motion is poorly modelled or with unexpected motions. In this paper, an alternative to address people tracking is presented. The proposed algorithm is based in particle filters, but instead of using a dynamical model, it uses background subtraction to predict future locations of particles. The algorithm is able to track people in omnidirectional sequences with a low frame rate (one or two frames per second). Our approach can tackle unexpected discontinuities and changes in the direction of the motion. The main goal of the paper is to track people from laboratories, but it has applications in surveillance, mainly in controlled environments.