gebhart/patrepeval huggingface dataset:
A framework for reliable routing in mobile ad hoc networks (2004)

Mobile ad hoc networks consist of nodes that are often vulnerable to failure. As such, it is important to provide redundancy in terms of providing multiple node-disjoint paths from a source to a destination. We first propose a modified version of the popular AODV protocol that allows us to discover multiple node-disjoint paths from a source to a destination. We find that very few of such paths can be found. Furthermore, as distances between sources and destinations increase, bottlenecks inevitably occur and thus, the possibility of finding multiple paths is considerably reduced. We conclude that it is necessary to place what we call reliable nodes (in terms of both being robust to failure and being secure) in the network for efficient operations. We propose a deployment strategy that determines the positions and the trajectories of these reliable nodes such that we can achieve a framework for reliably routing information. We define a notion of a reliable path which is made up of multiple segments, each of which either entirely consists of reliable nodes, or contains a preset number of multiple paths between the end points of the segment. We show that the probability of establishing a reliable path between a random source and destination pair increases considerably even with a low percentage of reliable nodes when we control their positions and trajectories in accordance with our algorithm.
IL-7/anti–IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R (2013)

Interleukin-7 (IL-7) is essential to T-cell survival as well as homeostatic proliferation, and clinical trials that exploit the mitogenic effects of IL-7 have achieved success in treating human diseases. In mice, the in vivo potency of IL-7 improves dramatically when it is administered as a complex with the anti-IL-7 neutralizing monoclonal antibody clone M25. However, the mechanism whereby M25 augments IL-7 potency is unknown. We have analyzed the discrete contributions of the antibody constant (Fc) and IL-7-binding (Fab) domains to the mechanism. By engaging the neonatal Fc receptor the Fc domain extends the in vivo lifespan of IL-7/M25 complexes and accounts for the majority of their activity. Unexpectedly, the IL-7-neutralizing Fab domain provides an additional, albeit smaller, contribution, possibly by serving as a cytokine depot. This study is the first to demonstrate that the neutralizing aspect of the monoclonal antibody is directly involved in enhancing the potency of a cytokine with a single form of receptor. Lessons from the mechanism of IL-7/M25 complexes inform the design of next-generation cytokine therapeutics.
Low Dose Guar in a Novel Food Product: Improved Metabolic Control in Non‐insulin‐dependent Diabetes (1987)

Sixteen non-insulin-dependent diabetic patients, mean age 60 years (range 47-69 years) and duration of diabetes 9 years (2-20 years), completed a randomized cross-over study of three 6-week periods separated by 2-week intervals to minimize carry-over effects, in which their usual bread was replaced by either control bread, guar bread (100 g guar/kg wheat flour), or control bread plus a guar granulate. The mean (+/- SEM) intake of guar taken in bread was 7.6 +/- 0.7 g/day (range 3.1-14.3 g/day). The granulate was taken in a dose of 5 g twice daily which provided 8.3 g guar/day. Significant reductions were found in glycosylated haemoglobin after guar bread (11.5 +/- 0.8% to 10.7 +/- 0.8%; p less than 0.02) and after guar granulate (11.2 +/- 0.8% to 10.6 +/- 0.7%; p less than 0.05) compared with control bread. Total cholesterol was also reduced significantly after both guar bread and guar granulate (p less than 0.01, p less than 0.02), the changes being due to LDL-cholesterol. Dietary intakes and body weight did not change. No significant side-effects were reported; 14 subjects found guar bread more palatable than guar granulate but 8 preferred the granulate for its convenience. We conclude that a lower than convential dose of guar can be effective and palatable. The incorporation of guar into food increases its metabolic benefits and palatability.
Evaluation of the efficacy of oral cromolyn sodium or an oligoantigenic diet in children with atopic dermatitis: a multicenter study of 1085 patients. (1997)

One thousand eighty-five children with atopic dermatitis were enrolled in a multicenter study to evaluate the efficacy of 4 weeks of oral sodium cromoglycate or 4 weeks of a restricted diet. One thousand-eleven children (93%) concluded the study. At the end of the trial there was a significant improvement in skin lesions in the two groups: 61% of the patients in the sodium cromoglycate group and 69% in the restricted diet showed a significant improvement in atopic dermatitis. We concluded that, at least in our experimental design, both sodium cromoglycate and a restricted diet are equally effective in atopic dermatitis.
Emergence of Imipenem-Resistant Gram-Negative Bacilli in Intestinal Flora of Intensive Care Patients (2013)

Intestinal flora contains a reservoir of Gram-negative bacilli (GNB) resistant to cephalosporins, which are potentially pathogenic for intensive care unit (ICU) patients; this has led to increasing use of carbapenems. The emergence of carbapenem resistance is a major concern for ICUs. Therefore, in this study, we aimed to assess the intestinal carriage of imipenem-resistant GNB (IR-GNB) in intensive care patients. For 6 months, 523 consecutive ICU patients were screened for rectal IR-GNB colonization upon admission and weekly thereafter. The phenotypes and genotypes of all isolates were determined, and a case control study was performed to identify risk factors for colonization. The IR-GNB colonization rate increased regularly from 5.6% after 1 week to 58.6% after 6 weeks in the ICU. In all, 56 IR-GNB strains were collected from 50 patients: 36 Pseudomonas aeruginosa strains, 12 Stenotrophomonas maltophilia strains, 6 Enterobacteriaceae strains, and 2 Acinetobacter baumannii strains. In P. aeruginosa, imipenem resistance was due to chromosomally encoded resistance (32 strains) or carbapenemase production (4 strains). In the Enterobacteriaceae strains, resistance was due to AmpC cephalosporinase and/or extended-spectrum β-lactamase production with porin loss. Genomic comparison showed that the strains were highly diverse, with 8 exceptions (4 VIM-2 carbapenemase-producing P. aeruginosa strains, 2 Klebsiella pneumoniae strains, and 2 S. maltophilia strains). The main risk factor for IR-GNB colonization was prior imipenem exposure. The odds ratio for colonization was already as high as 5.9 (95% confidence interval [95% CI], 1.5 to 25.7) after 1 to 3 days of exposure and increased to 7.8 (95% CI, 2.4 to 29.8) thereafter. In conclusion, even brief exposure to imipenem is a major risk factor for IR-GNB carriage.
Autologous Dental Pulp Stem Cells in Regeneration of Defect Created in Canine Periodontal Tissue (2013)

This study aimed to investigate effects of dental pulp stem cells (DPSCs) on regeneration of a defect experimentally created in the periodontium of a canine model. Surgically created mesial 3-walled periodontal defects with ligature-induced periodontitis were produced bilaterally in the first lower premolar teeth of 10 mongrel dogs. Simultaneously, DPSCs were derived from the maxillary premolar teeth of the same dogs. Four weeks after creation of the periodontitis model, autologous passaged-3 DPSCs combined with Bio-Oss were implanted on one side as the test group. On the other side, only Bio-Oss was implanted as a control. Eight weeks after surgery, regeneration of the periodontal defects was evaluated histologically and histomorphometrically in terms of bone, periodontal ligament (PDL), and cement formation. Histologically, in all test specimens (10 defects), regeneration of cementum, bone, and PDL was observed. In the control groups, although we observed the regeneration of bone in all defects, the formation of cementum was seen in 9 defects and PDL was seen in 8 defects. Histomorphometric analyses showed that the amount of regenerated cementum and PDL in the test groups (3.83 ± 1.32 mm and 3.30 ± 1.12 mm, respectively) was significantly higher than that of the control groups (2.42 ± 1.40 mm and 1.77 ± 1.27 mm, respectively; P < .05). A biocomplex consisting of DPSCs and Bio-Oss would be promising in regeneration of periodontal tissues.
Experimental demonstration of OpenFlow-based control plane for elastic lightpath provisioning in Flexi-Grid optical networks (2013)

Due to the prominent performance on networking virtualization and programmability, OpenFlow is widely regarded as a promising control plane technology in packet-switched IP networks as well as wavelength-switched optical networks. For the purpose of applying software programmable feature to future optical networks, we propose an OpenFlow-based control plane in Flexi-Grid optical networks. Experimental results demonstrate its feasibility of dynamic lightpath establishment and adjustment via extended OpenFlow protocol. Wireshark captures of the signaling procedure are printed out. Additionally, the overall latency including signaling and hardware for lightpath setup and adjustment is also reported.
EASI, (objective) SCORAD and POEM for atopic eczema: responsiveness and minimal clinically important difference (2011)

The objective SCORAD and SCORAD showed a fair responsiveness. The MCIDs are an important prerequisite for the interpretation of published eczema trials and for the planning/sample size estimation of future trials.
Nystagmus (2001)

This article reviews the recent literature on nystagmus and various aspects of the pathophysiology of congenital idiopathic nystagmus and nystagmus treatment. One paper shows a new classification of latent/manifest latent nystagmus based on eye movement recordings. Nystagmus associated with complex syndromes and with onset in childhood represents the subject of several important recent articles, as does acquired nystagmus. Nystagmus as a manifestation of the toxicity of pharmacological agents is becoming increasingly recognized. Important contributions have been made to the genetics of various forms of nystagmus that represent an essential feature of retinal diseases, such as congenital stationary night blindness, albinism, blue cone monochromatism, and achromatopsia.
Cyclooxygenase-1 and -2 are expressed by human T cells (1999)

In vitro, prostaglandins (PG) have strong inhibitory effects on T cell activation and proliferation and inhibitors of PG synthesis (NSAID) increase proliferation and activation of T cells. Although most studies have failed to demonstrate cyclooxygenase (COX) activity in lymphocytes, there is contradictory evidence on the synthesis of different PG. We have studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot the expression of COX-1 and -2 mRNA and protein in resting and activated peripheral blood or Jurkat T cells. Cells were activated by T cell receptor triggering with OKT3 antibodies and activation confirmed by flow cytometric analysis of surface CD69. COX enzymatic activity was measured by determination of arachidonic acid (AA)-induced PG synthesis. Both peripheral blood and Jurkat T cells expressed COX-1 and -2 mRNA and protein. COX-1 was constitutively expressed and did not change after OKT3 stimulation. COX-2 was inducible upon OKT3-induced activation. In spite of the presence of COX mRNA and immunoreactive protein, AA-induced PG synthesis was not detected at the EIA detection (pM) level. The potential role of cyclooxygenases in T cells deserves further study, since no PG of the studied series seem to be synthesized by T cells.
Thermodynamic Study on Vanadium Precipitation with Calcium Salt (2014)

According to the principle of simultaneous equilibrium and the law of mass conservation,thermodynamic equilibrium diagrams of Ca-V(Ⅴ)-H2O system were established with different concentrations of total free calcium at 25 ℃,and then thermodynamic analysis was made of the system.The results show that the six stable solid regions of V2O5,Ca(VO3)2,Ca2V2O7,Ca3(VO4)2,Ca3(VO4)2+Ca(OH)2and Ca(OH)2appear in turn with increase of the system pH value.When total free calcium concentration is 0.01mol/L in the equilibrium system,at the pH region of 5.1~9.8,vanadium is precipitated in the form of Ca(VO3)2and vanadium concentration can be reduced to 2.2×10-3 mol/L.At pH region of 9.8~10.3, Ca2V2O7is formed and corresponding vanadium concentration can be decreased to 1.2×10-2 mol/L.At the pH region of 10.3~12.6,Ca3(VO4)2is precipitated and the minimum vanadium concentration can reach to 2.4×10-4 mol/L,which is the best vanadium precipitation effect.When total free calcium concentration is 0.01~1.0mol/L,theoretical optimum pH value for vanadium precipitation is kept at about 11.0~12.6.
Downlink performance of adaptive antennas with null broadening (2003)

We compare different null broadening schemes and their ability to decrease the radiated interference for the co-channel users in a space division multiple access system with adaptive antennas. By link level simulations of the GSM 1800 system in urban and suburban environments we show that a gain of up to 8 dB in SNIR is feasible with null broadening. Therefore adequate null broadening seems to be a must in the downlink beamforming process.
VPV-videotext programs videorecorder (1988)

The VPV (video programs video recorder) systems standard allows unequivocal recognition and interpretation of video cassette recorded (VCR) timer preprogramming data in a teletext program schedule. Together with a machine-readable page memory this makes it possible to implement fully-automatic timer-programming procedures in the VCR. The VPV specification defines data formats and rules for their correlation; it gives a number of example program tables to show the broadcaster how to apply the standards. For the VCR manufacturer, it recommends how to process the VPV program pages.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A practical solution for accurate studies of NDIR gas sensor pressure dependence. Lab test bench, software and calculation algorithm (2016)

This paper presents a lab test system for studying pressure dependence of NDIR gas sensors in accuracy demanding applications. The test system consists of a hardware test bench, user software (LabVIEW based) and a calculation algorithm. The lab test bench provides highly accurate test environment for collecting characterization data. The software and the calculation algorithm process the data to derive accurate compensation parameters for each specific design of NDIR sensors. The compensation parameters are used to normalize the measured concentration to the values valid for standard atmospheric pressure.
Built-In Scrambling Analysis for Yield Enhancement of Embedded Memories (2014)

Fault scrambling technique is considered a promising way to distribute faulty bits into different code words such that the number of faulty cells in each codeword is below the protection capability of the adopted EDAC coding techniques. However, the effectiveness of the scrambling technique depends on the determination of the row/column scrambling control words. Therefore, we propose a heuristic algorithm suitable for built-in implementation for the evaluation of control words based on the fault bitmap and the specifications of the memory. The corresponding built-in scrambling analysis (BISA) circuit is also proposed. The BISA module can be easily integrated into the conventional built-in self-repair (BISR) module. A simulator is developed to evaluate the hardware overhead and repair rate. According to experimental results, the repair rate can be improved significantly with negligible hardware overhead.
Protein Phosphatase Type 1 Regulates Ion Homeostasis in <i>Saccharomyces cerevisiae</i> (2002)

Protein phosphatase type 1 (PP1) is encoded by the essential gene GLC7 in Saccharomyces cerevisiae. glc7-109 (K259A, R260A) has a dominant, hyperglycogen defect and a recessive, ion and drug sensitivity. Surprisingly, the hyperglycogen phenotype is partially retained in null mutants of GAC1, GIP2, and PIG1, which encode potential glycogen-targeting subunits of Glc7. The R260A substitution in GLC7 is responsible for the dominant and recessive traits of glc7-109. Another mutation at this residue, glc7-R260P, confers only salt sensitivity, indicating that the glycogen and salt traits of glc7-109 are due to defects in distinct physiological pathways. The glc7-109 mutant is sensitive to cations, aminoglycosides, and alkaline pH and exhibits increased rates of l-leucine and 3,3'-dihexyloxacarbocyanine iodide uptake, but it is resistant to molar concentrations of sorbitol or KCl, indicating that it has normal osmoregulation. KCl suppresses the ion and drug sensitivities of the glc7-109 mutant. The CsCl sensitivity of this mutant is suppressed by recessive mutations in PMA1, which encodes the essential plasma membrane H(+)ATPase. Together, these results indicate that Glc7 regulates ion homeostasis by controlling ion transport and/or plasma membrane potential, a new role for Glc7 in budding yeast.
Vortex states in high-T<sub>c</sub> superconductors and superconductivity in modern nano-science and engineering (2005)

A brief review is given on the recent development of the vortex engineering research in our group with special emphasis on the geometrical confinement of vortices into micron-size of samples. We show that the static as well as dynamical nature of vortices is strongly affected by the geometrical constraints, which can be manipulated by the recent nano-technology engineering artificially. One of the spectacular phenomena in this context is a formation of self-organized vortex structures occuring both in static and dynamic manners. The static behaviors have been studied by the scanning SQUID microscope technique and the dynamical behaviors are mostly done in transport measurements. Some technical development of these methods is also discussed. We stress that a common generic concept here is the confinement in nano-scale superconducting systems by the existing surfaces (boundaries), which plays an essential role for the phenomena. Some typical examples are shown, such as results on the vortex arrangement in micron size superconducting disks, a formation of the giant vortex state in such a particular case and the dynamical effects of vortices, especially in the case of Josephson vortices confined in an intrinsic Josephson junction in micron size single crystal Bi2Sr2CaCu2O8+δ, where the dynamical effect of the confinement provides rich linear and non-linear phenomena due to the excitation of Josephson plasma. Making use of Josephson plasma excitations, a generator operating at T (Hz) frequencies is proposed in this intrinsic Josephson junctions. These phenomena are expected to be all beneficial to potential applications.
Short‐ and Long‐Term Modulation of Synaptic Inputs to Brain Reward Areas by Nicotine (2003)

Dopamine signaling in brain reward areas is a key element in the development of drug abuse and dependence. Recent anatomical and electrophysiological research has begun to elucidate both complexity and specificity in synaptic connections between ventral tegmental neurons and their inputs. Specifically, the activity of dopamine neurons in the ventral tegmental area relies on the combination of both excitatory and inhibitory inputs. Controlling endogenous neurotransmission to dopamine neurons is one mechanism by which drugs of abuse affect both transient and long-term changes in synaptic activity. Here, we review recent findings concerning glutamatergic, GABAergic, and cholinergic inputs to dopamine neurons, and their roles in the reinforcement associated with drug abuse. Importantly, several studies support that a single drug exposure can lead to changes in synaptic strength that are associated with learning and memory. Ultimately, these cellular changes could underlie the long-lasting effects of drugs. Furthermore, nicotinic acetylcholine receptors in the ventral tegmental area emerge as a possible common target for the behavioral and cellular actions not only of nicotine, but also of several other drugs of abuse. Finally, we explore age-related differences in nicotine sensitivity in order to understand both human epidemiological data, and laboratory animal behavioral findings that suggest adolescents are more susceptible to developing nicotine dependence.
Bacteriostatic Activity of Bovine Colostrum (1991)

Succeeding the previous report on antivirus activity of non immunized bovine colostrum immunoglobulin, we studied the bacteriostatic activity of the immunoglobulin, lactoferrin and lactoferrin Fe by using the automated antimicrobial susceptibility testing system. We have presented the representative positive and negative reactions. Then, we have reported that the immunoglobulin was effective in 10 of a total of 20 species which we examined. In some species, the lactoferrin was slightly more effective than the immunoglobulin was. These results indicated that the immunoglobulin, lactoferrin and lactoferrin Fe were useful for the bacteriostatic reaction.
Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity (2012)

Soy isoflavone supplements, derived by extraction or chemical synthesis, are significantly more effective than placebo in reducing the frequency and severity of hot flashes. Additional studies are needed to further address the complex array of factors that may affect efficacy, such as dose, isoflavone form, baseline hot flash frequency, and treatment duration.
The influence of temperature and specimen size on the flexural properties of pmma bone cement (1984)

A three-stage investigation was undertaken to examine the influence of specimen size and polymerization environment on the flexural properties of PMMA. In the first stage, specimens were cut from large pieces of commercially cast acrylic (lucite) and self-curing dental acrylic. The material properties of the cast acrylic as calculated from the results of flexural testing were not influenced by specimen size in the range of 1 X 10 X 30 to 3 X 10 X 60 mm, whereas 1-mm thick dental cement specimens had 12% (p less than 0.001) higher stress and 24% (p less than 0.001) higher strain to failure than 3-mm specimens cut from the same sample. In the second stage, self-curing dental cement and Simplex P bone cement were molded in different thicknesses. These experiments demonstrated that molding thin 1.6-mm specimens resulted in increases of 14% (p less than 0.001) in stress and 30% (p less than 0.001) in strain to failure as compared with 3.2-mm specimens, which were greater differences than those due to the specimen thickness effects alone. In the third stage, temperatures of cement were monitored during polymerization, and cements were molded at different temperatures. These results demonstrated that thicker cement samples reached higher temperatures and that cement samples polymerized at lower temperatures (21 versus 37 degrees C) had 12% (p less than 0.001) greater stress and 105% (p less than 0.001) greater strain to failure.