gebhart/patrepeval huggingface dataset:
Myogenesis in the mouse embryo: differential onset of expression of myogenic proteins and the involvement of titin in myofibril assembly. (1989)

Antibodies to muscle-specific proteins were used in immunofluorescence to monitor the development of skeletal muscle during mouse embryogenesis. At gestation day (g.d.) 9 a single layer of vimentin filament containing cells in the myotome domain of cervical somites begins to stain positively for myogenic proteins. The muscle-specific proteins are expressed in a specific order between g.d. 9 and 9.5. Desmin is detected first, then titin, then the muscle specific actin and myosin heavy chains, and finally nebulin. At g.d. 9.5 fibrous desmin structures are already present, while for the other myogenic proteins no structure can be detected. Some prefusion myoblasts display at g.d. 11 and 12 tiny and immature myofibrils. These reveal a periodic pattern of myosin, nebulin, and those titin epitopes known to occur at and close to the Z line. In contrast titin epitopes, which are present in mature myofibrils along the A band and at the A-I junction, are still randomly distributed. We propose, that the Z line connected structures and the A bands (myosin filaments) assemble independently, and that the known interaction of the I-Z-I brushes with the A bands occurs at a later developmental stage. After fusion of myoblasts to myotubes at g.d. 13 and 14 all titin epitopes show the myofibrillar banding pattern. The predominantly longitudinal orientation of desmin filaments seen in myoblasts and in early myotubes is transformed at g.d. 17 and 18 to distinct Z line connected striations. Vimentin, still present together with desmin in the myoblasts, is lost from the myotubes. Our results indicate that the putative elastic titin filaments act as integrators during skeletal muscle development. Some developmental aspects of eye and limb muscles are also described.
A method for fast multislice T1 measurement: Feasibility studies on phantoms, young children, and children with canavan's disease (2000)

We have developed a multislice protocol for quantitative T1 measurements in which the processing time and the acquisition time are under 2 minutes each for a complete brain study of 15 slices. An echoplanar, inversion-recovery image sequence is designed to collect data suitable for analysis using a linear regression algorithm. The precision is approximately twice the noise to signal ratio of the images. The accuracy of the protocol is better than 1% for T1 in the range 0-2 seconds and deviates slightly for longer T1 values. The protocol is insensitive to B1 field values. If needed, the data can be postprocessed using a slow, nonlinear algorithm to give an accuracy of less than 1% and a precision of approximately the noise to signal ratio throughout a range of T1 values from 0 to 4 seconds.
Wafer fusion bonding and its application to silicon-on-insulator fabrication (1991)

The principles of the wafer fusion bonding technique at room temperature and with thermal treatment are described. Experiments using plain and patterned silicon wafers coated with different surface materials are presented. Results obtained for different thermal annealing conditions are discussed in terms of homogeneity and strength of the bond. Thinning of the bonded wafers is performed by grinding and polishing or with preferential etch techniques using p+ etchstops. Uniform silicon-on-insulator (SOI) films with thicknesses 1 mu m-30 mu m have been obtained.
Chemistry of tetrakis(triethyl phosphite) nickel hydride, HNi[P(OET)3]4+. III. Proton nuclear magnetic resonance study of reactions with dienes (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of tetrakis(triethyl phosphite) nickel hydride, HNi[P(OET)3]4+. III. Proton nuclear magnetic resonance study of reactions with dienesChadwick A. TolmanCite this: J. Am. Chem. Soc. 1970, 92, 23, 6785–6790Publication Date (Print):November 1, 1970Publication History Published online1 May 2002Published inissue 1 November 1970https://pubs.acs.org/doi/10.1021/ja00726a012https://doi.org/10.1021/ja00726a012research-articleACS PublicationsRequest reuse permissionsArticle Views1789Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Robotic data mules for collecting data over sparse sensor fields (2011)

Abstract We present a robotic system for collecting data from wireless devices dispersed across a large environment. In such applications, deploying a network of stationary wireless sensors may be infeasible because many relay nodes must be deployed to ensure connectivity. Instead, our system utilizes robots that act as data mules and gather the data from wireless sensor network nodes. We address the problem of planning paths of multiple robots so as to collect the data from all sensors in the shortest time. In this new routing problem, which we call the data gathering problem (DGP), the total download time depends on not only the robots' travel time but also the time to download data from a sensor and the number of sensors assigned to the robot. We start with a special case of DGP in which the robots' motion is restricted to a curve that contains the base station at one end. For this version, we present an optimal algorithm. Next, we study the two‐dimensional version and present a constant factor approximation algorithm for DGP on the plane. Finally, we present field experiments in which an autonomous robotic data mule collects data from the nodes of a wireless sensor network deployed over a large field. © 2011 Wiley Periodicals, Inc.
Use of osteoinductive implants in the treatment of bone defects. (1994)

Osteogenic proteins (OPs) are a family of bone matrix polypeptides isolated from a variety of mammalian species, including mouse, rat, bovine, monkey, and man. OPs initiate chondroblastic differentiation in pluripotent mesenchymal progenitor cells, followed by the synthesis of new bone by endochondral ossification. OPs have the ability to induce healing of osteoperiosteal defects in several animal models, supporting a possible therapeutic role in the reconstruction of bone defects. OPs are responsible for the osteoinductive capacity of demineralized bone matrix (DBM) implants, which may also prove to be clinically useful. Preliminary studies using purified, naturally occurring human osteogenic proteins in the clinical management of non-unions have reported promising results. A prospective, randomized clinical trial is currently underway, comparing recombinant human osteogenic protein-1 (rhOP-1) to autograft in the treatment of tibial non-unions. The use of osteogenic protein implants to augment or replace autogenous and allogenous bone grafts will reduce morbidity, and circumvent the risk of disease transmission associated with transplantation.
Effects of 1,3-Butadiene, Isoprene, and Their Photochemical Degradation Products on Human Lung Cells (2004)

Because of potential exposure both in the workplace and from ambient air, the known carcinogen 1,3-butadiene (BD) is considered a priority hazardous air pollutant. BD and its 2-methyl analog, isoprene (ISO), are chemically similar but have very different toxicities, with ISO showing no significant carcinogenesis. Once released into the atmosphere, reactions with species induced by sunlight and nitrogen oxides convert BD and ISO into several photochemical reaction products. In this study, we determined the relative toxicity and inflammatory gene expression induced by exposure of A549 cells to BD, ISO, and their photochemical degradation products in the presence of nitric oxide. Gas chromatography and mass spectrometry analyses indicate the initial and major photochemical products produced during these experiments for BD are acrolein, acetaldehyde, and formaldehyde, and products for ISO are methacrolein, methyl vinyl ketone, and formaldehyde; both formed < 200 ppb of ozone. After exposure the cells were examined for cytotoxicity and interleukin-8 (IL-8) gene expression, as a marker for inflammation. These results indicate that although BD and ISO alone caused similar cytotoxicity and IL-8 responses compared with the air control, their photochemical products significantly enhanced cytotoxicity and IL-8 gene expression. This suggests that once ISO and BD are released into the environment, reactions occurring in the atmosphere transform these hydrocarbons into products that induce potentially greater adverse health effects than the emitted hydrocarbons by themselves. In addition, the data suggest that based on the carbon concentration or per carbon basis, biogenic ISO transforms into products with proinflammatory potential similar to that of BD products.
A fast hybrid algorithm combining regularized motion tracking and predictive search for reducing the occurrence of large displacement errors (2011)

A hybrid approach that inherits both the robustness of the regularized motion tracking approach and the efficiency of the predictive search approach is reported. The basic idea is to use regularized speckle tracking to obtain high-quality seeds in an explorative search that can be used in the subsequent intelligent predictive search. The performance of the hybrid speckle-tracking algorithm was compared with three published speckle-tracking methods using in vivo breast lesion data. We found that the hybrid algorithm provided higher displacement quality metric values, lower root mean squared errors compared with a locally smoothed displacement field, and higher improvement ratios compared with the classic block-matching algorithm. On the basis of these comparisons, we concluded that the hybrid method can further enhance the accuracy of speckle tracking compared with its real-time counterparts, at the expense of slightly higher computational demands.
Macintosh System 7 at your fingertips (1992)

An overview of new features how to use the increased power and versatility of the recognized system folder the finder - new commands and features of the Apple, file, edit, view, lable, help, special and application menus sharing files, folders, disks, programs - using the built-in filesharing capabilities installation keyboard shortcuts troubleshooting.
The effects of H/sub 2/-O/sub 2/-plasma treatment on the characteristics of polysilicon thin-film transistors (1993)

The effects of H/sub 2/-plasma followed by O/sub 2/-plasma treatment on n-channel polysilicon thin-film transistors (TFTs) were investigated. It was found that the H/sub 2/-O/sub 2/-plasma treatment is more effective in passivating the trap states of polysilicon films than the H/sub 2/-plasma or O/sub 2/-plasma treatment only. Hence, it is more effective in improving the device performance with regard to subthreshold swing, carrier mobility, and the current ON/OFF ratio. It is also found that thermal annealing of plasma-treated devices increases the deep states but has no effect on the tail states of the devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Superior Non-Symmetrical NCP Pincer Type Palladacycle Catalyst Precursor for the Coupling of Aryl Boronic Acids with Aryl Chlorides (2003)

The air and water stable non-symmetrical pincer palladacycle [Me2NCH2(Cl)C=C(CH2)2OP(i-Pr)2-kNkCkP]PdCl 5, easily prepared from the chloropalladation of the hetero-substituted alkyne Me2NCH2C≡C(CH2)2OP(i-Pr)2, is a highly efficient catalyst precursor for the coupling of aryl boronic acids and aryl chlorides. Both electron-rich and electron-poor aryl chlorides are efficiently coupled in the presence of 5 to furnish the corresponding cross-coupled products in excellent yields, and a wide variety of functional groups are tolerated in both aryl chloride and aryl boronic acid.
Experimental search for the electrical spin injection in a semiconductor (2000)

The electrical injection of spin-polarized electrons in a semiconductor can be achieved in principle by driving a current from a ferromagnetic metal, where current is known to be significantly spin polarized, into the semiconductor via Ohmic conduction. For detection a second ferromagnet can be used as a drain. We studied submicron lateral spin valve junctions, based on high-mobility InAs/AlSb two-dimensional electron gas, with Ni, Co, and permalloy as ferromagnetic electrodes. In the standard geometry it is very difficult to separate true spin injection from other effects, including local Hall effect, anomalous magnetoresistance contribution from the ferromagnetic electrodes and weak localization/antilocalization corrections, which can closely mimic the signal expected from spin valve effect. The reduction in size, and the use of a multiterminal nonlocal geometry allowed us to reduce the unwanted effects to a minimum. Despite all our efforts, we have not been able to observe spin injection. However, we find that this ``negative'' result in these systems is actually consistent with theoretical predictions for spin transport in diffusive systems.
Detection of a New SHV-Type Extended-Spectrum β-Lactamase, SHV-31, in a <i>Klebsiella pneumoniae</i> Strain Causing a Large Nosocomial Outbreak in The Netherlands (2006)

A Klebsiella pneumoniae strain resistant to third-generation cephalosporins was isolated in the eastern Netherlands. The strain was found to carry a novel extended-spectrum beta-lactamase, namely, SHV-31. The combination of the two mutations by which SHV-31 differs from SHV-1, namely, L35Q and E240K, had previously only been described in association with one or more additional mutations.
Effects of Additives on the Survival of Lactic Streptococci in Frozen Storage (1966)

Three single-strain cultures, Streptococcus lactis C(2), S. cremoris R(1), and S. diacetilactis DRC(2), were frozen and stored in skim milk, in skim milk containing apple juice, and in skim milk containing one of the following additives: glycerol (10%, v/v), dimethyl sulfoxide (10%, v/v), l-malic acid (0.5 and 2.0%, w/v), acetamide (0.5 and 2.0%, w/v), or succinimide (0.5 and 2.0%, w/v). Cultures were frozen and stored at -23.3 C, frozen and stored at -196 C in liquid nitrogen, or frozen at -196 C and stored at -23.3 C. Cultures frozen and stored at -196 C in liquid nitrogen gave the greatest recovery of viable cells. The number of cells surviving after storage at -23.3 C was greater when the cells had been frozen in liquid N(2) than when they had been frozen at -23.3 C. All strains stored at -23.3 C showed a decrease in numbers of surviving cells; additives, particularly l-malic acid and apple juice, were advantageous in preserving the viability of the S. lactis C(2) and S. cremoris R(1) strains, but had little or no effect on the survival of S. diacetilactis DRC(2). l-Malic acid and apple juice stimulated acid production for all cultures in activity tests following incubation after thawing, whereas glycerol and dimethyl sulfoxide retarded its development.
Primary structure of bovine lactoperoxidase, a fourth member of a mammalian heme peroxidase family (1991)

Much is known about bovine lactoperoxidase but no data are available on its primary structure. In this work its main active fraction was isolated from cow's milk and sequenced using a conventional strategy. A clear similarity was found with human myeloperoxidase, eosinophil peroxidase and thyroperoxidase, the sequences of which were recently elucidated from those of their cDNAs and/or genes. The single peptide chain of bovine lactoperoxidase contains 612 amino acid residues, including 15 half-cystines and 4 or 5 potential N-glycosylation sites. The corresponding peptide segments of human myeloperoxidase, eosinophil peroxidase and thyroperoxidase display 55%, 54% and 45% identity with bovine lactoperoxidase, respectively, with 14 out of the 15 half-cystines present in each of the four enzymes being located in identical positions. The occurrence of an odd number of half-cystines in bovine lactoperoxidase supports the recent finding of a heme thiol released from this enzyme by a reducing agent, suggesting that the heme is bound to the peptide chain via a disulfide linkage, since the absence of free thiol in the enzyme was reported long ago.
ar-2-Tetralol Derivatives (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTar-2-Tetralol DerivativesRobert L. HullCite this: J. Am. Chem. Soc. 1955, 77, 23, 6376–6379Publication Date (Print):December 1, 1955Publication History Published online1 May 2002Published inissue 1 December 1955https://pubs.acs.org/doi/10.1021/ja01628a096https://doi.org/10.1021/ja01628a096research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analysis of the concentrations and size distributions of cell-free DNA in schizophrenia using fluorescence correlation spectroscopy (2018)

Cell-free DNA (cfDNA), which is primarily released following cell death, has been described and developed to serve as an effective biomarker in autoimmune diseases which may share the pathogenesis with schizophrenia. In this study, we hypothesized and explored whether the concentrations and size distributions of cfDNA are abnormal in schizophrenia. A total of 65 patients with schizophrenia (SZ), 29 patients with mood disorders (MD) and 62 matched healthy controls (HC) were included in the study. Fluorescence correlation spectroscopy was used to assay the molar concentrations and size distributions of cfDNA. Fluorometric quantification and quantitative real-time PCR (qPCR) were performed to verify the results. The cfDNA levels were approximately two-fold higher in the SZ group ((29 ± 15) nM) than in the healthy controls ((15 ± 9) nM; P-value = 0.00062), but the levels in patients with MD were not significantly different from those in the healthy controls ((17 ± 10) nM; P-value = 0.343). According to the size distribution analysis, cfDNA in schizophrenia patients was composed of shorter DNA molecules and showed an apoptosis-like distribution pattern. Our study shows the elevated levels and short sizes of cfDNA in schizophrenia patients, which provide direct evidences supporting increased apoptotic activity in the disease. cfDNA may be developed to serve as an auxiliary diagnostic marker for the disease in the future.
Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration. (2005)

Inadvertent and accidental epinephrine overdose might result in potentially lethal complications. We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously. He developed significant ischemic changes in standard 12-lead electrocardiogram, transiently raised cardiac enzymes, reduced left ventricular systolic function, pulmonary edema and pulmonary hemorrhage. It is suggested that special precautionary measures should be taken regarding the dose and the route while administering epinephrine to avoid mishaps.
Thermal beam distortions in end-pumped Nd:YAG, Nd:GSGG, and Nd:YLF rods (1994)

The thermally induced beam distortions in end-pumped Nd:YAG, Nd:GSGG, and Nd:YLF rods were analyzed and the influence of edge- and face-cooling was investigated. The distributions of temperature, stress, and strain in the crystals were calculated by finite element analysis. Based on these data, the space-resolved changes of the refractive index were determined considering thermal dispersion, surface deformation, and strain-induced birefringence. The resulting optical path difference for one round-trip in the end-pumped rods was integrated numerically. For each rod, the induced thermal lens was determined over the extent of the pump spot radius. The calculations of the optical path difference were experimentally confirmed by investigations using a modified Twyman-Green interferometer with a polarized HeNe probe beam at 633 nm under lasing and nonlasing conditions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Time-of-flight dependency on transducer separation distance in a reflective-path guided-wave ultrasonic flow meter at zero flow conditions (2017)

Transit-time flow meters based on guided ultrasonic wave propagation in the pipe spool have several advantages compared to traditional inline ultrasonic flow metering. The extended interrogation field, obtained by continuous leakage from guided waves traveling in the pipe wall, increases robustness toward entrained particles or gas in the flow. In reflective-path guided-wave ultrasonic flow meters (GW-UFMs), the flow equations are derived from signals propagating solely in the pipe wall and from signals passing twice through the fluid. In addition to the time-of-flight (TOF) through the fluid, the fluid path experiences an additional time delay upon reflection at the opposite pipe wall due to specular and non-specular reflections. The present work investigates the influence of these reflections on the TOF in a reflective-path GW-UFM as a function of transducer separation distance at zero flow conditions. Two models are used to describe the signal propagation through the system: (i) a transient full-wave finite element model, and (ii) a combined plane-wave and ray-tracing model. The study shows that a range-dependent time delay is associated with the reflection of the fluid path, introducing transmitter-receiver distance dependence. Based on these results, the applicability of the flow equations derived using model (ii) is discussed.