gebhart/patrepeval huggingface dataset:
ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome (2005)

Correct folding of nascent polypeptide chains within the ER is critical for function, assembly into multi-subunit complexes and trafficking through the exocytic pathway for secretory and cell surface proteins. This process is rather inefficient, and a substantial proportion of nascent polypeptides is rejected by an ER quality control system and targeted for degradation. In some cases, only a minor fraction of nascent chains is correctly folded, and the smallest alteration to polypeptide primary structure (i.e. point mutation) can result in the complete loss of function with inherent pathological consequences; cystic fibrosis and emphysema result from such mutations. We have taken a bioinformatic approach to parse a large database of known disease susceptibility genes for candidates whose disease-associated alleles are likely prone to misfolding in the ER. Surprisingly, we find that proteins with ER-targeting signals are over represented in this database when compared with all predicted proteins in the human genome (45 versus 30%). We selected a subgroup of proteins that were positive for both an ER-targeting signal and a membrane-anchoring domain and thereby identified several ER-associated degradation diseases candidates. To determine whether our analysis had identified new ER-degradation substrates, we established that ER retention is indeed the mechanism underlying Robinow syndrome (RRS), one of the identified candidates. Specifically, mutant alleles of ROR2 that are associated with RRS are retained within the ER, whereas wild-type and non-pathogenic alleles are exported to the plasma membrane. These data both uncover a major pathogenic factor for RRS and indicate that misfolding of secretory proteins is likely to significantly contribute to human disease and morbidity.
Public key cryptography empowered smart dust is affordable (2008)

Public Key Cryptography (PKC), although very beneficial for key distribution, authentication and other related issues, was for a long time considered as too expensive for small, battery-powered and resource-constrained devices. In the recent years, first research groups started to cope with the challenges applying PKC in such environments. One of the results is that Elliptic Curve Cryptography (ECC) fits here perfectly, providing the level of security RSA does, but with much shorter keys. In this paper, we evaluate the power consumption induced by various PKC approaches including calculation and transmission costs. Our results clearly show that hardware accelerators significantly reduce the energy consumption and prolong lifetime of sensor nodes. Our solution for 163 bit ECC needs only 1.02 mm² cell area in a 0.25 µm technology and only 12.8 µWs per point multiplication. Due to its small size it can be manufactured for about 0.05 USD in mass production.
Influence of bulk diffusion on the counterion polarization in a condensed counterion model (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of bulk diffusion on the counterion polarization in a condensed counterion modelConstantino. Grosse and Kenneth R. FosterCite this: J. Phys. Chem. 1987, 91, 25, 6415–6417Publication Date (Print):December 1, 1987Publication History Published online1 May 2002Published inissue 1 December 1987https://pubs.acs.org/doi/10.1021/j100309a020https://doi.org/10.1021/j100309a020research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
THERAPEUTIC ACTIVITY OF LYSOSTAPHIN IN EXPERIMENTAL STAPHYLOCOCCAL INFECTIONS (1967)

When tested in three experimental staphylococcal infections—acute peritonitis in mice, mouse leg edema produced by a localized infection, and dermal rabbit ear infections—lysostaphin demonstrated in vivo chemotherapeutic activity. Doses of less than 0.007 mg/kg (intraperitoneally) and 0.5 mg/kg (subcutaneously) of lysostaphin prevented death in 50% of the mice with acute staphylococcal peritonitis. A single intramuscular dose (0.15 mg/mouse) of lysostaphin suppressed the swelling produced by the injection of staphylococci into mouse legs to 50% of that produced in untreated animals. Lysostaphin (0.05% by weight) incorporated into gels and applied topically eradicated staphylococci from experimental skin lesions on the ears of rabbits. Lysostaphin was absorbed and transported by the body fluids from the point of injection to the site of the infection producing a desirable antistaphylococcal effect.
Protein sequence comparisons show that the ‘pseudoproteases’ encoded by poxviruses and certain retroviruses belong to the deoxyuridine triphosphatase family (1990)

Amino acid sequence comparisons show extensive similarities among the deoxyuridine triphosphatases (dUTPases) of Escherichia coli and of herpesviruses, and the 'protease-like' or 'pseudoprotease' sequences encoded by certain retroviruses in the oncovirus and lentivirus families and by poxviruses. These relationships suggest strongly that the 'pseudoproteases' actually are dUTPases, and have not arisen by duplication of an oncovirus protease gene as had been suggested. The herpesvirus dUTPase sequences differ from the others in that they are longer (about 370 residues, against around 140) and one conserved element ('Motif 3') is displaced relative to its position in the other sequences; a model involving internal duplication of the herpesvirus gene can account effectively for these observations. Sequences closely similar to Motif 3 are also found in phosphofructokinases, where they form part of the active site and fructose phosphate binding structure; thus these sequences may represent a class of structural element generally involved in phosphate transfer to and from glycosides.
DBIT-direct backside interconnect technology: a manufacturable, bond wire free interconnect technology for microwave and millimeter wave MMICs (2002)

A novel, highly manufacturable, low loss interconnect technique-DBIT (Direct Backside Interconnect Technology)-is presented. Polymer bumps are used to provide RF and ground interconnects between the backside of the MMIC chip and the substrate. The RF interconnects have been characterized up to 40 GHz. Measured interconnections have a 24 GHz bandwidth with 0.05 dB insertion loss at 10 GHz. This approach eliminates wire bonds which are known to introduce significant parasitics including a variable series inductance and which constraint the design of microwave MCMs and single chip packages.
Imaging the carotid bifurcation using continuous-wave Doppler-shift ultrasound and spectral analysis. (1978)

A non-invasive method is described for visualizing the carotid bifurcation using a continuous-wave Doppler-shift technique simultaneously with spectral analysis of the blood velocities from all parts of the vessel lumen. The system is directional so that arteries can be visualized in the presence of signals from adjacent veins. The technique uses a transducer which is attached to a position-sensing arm so that the position of the ultrasound beam on the neck, when sensing arterial blood flow-velocities, can be translated onto a storage oscilloscope. By repeated passes of the transducer across the vessel lumen a 2 dimensional image of the carotid bifurcation is formed. As each image point is marked, the full spectrum of blood-velocities corresponding to that position is continuously displayed on a second oscilloscope beside the image scope. Ultrasound images are compared with arteriograms and both continuous-wave and pulsed Doppler ultrasound imaging systems are discussed.
Selective telomerization of butadiene with various nucleophiles catalyzed by polymer-bound palladium(0) complexes (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective telomerization of butadiene with various nucleophiles catalyzed by polymer-bound palladium(0) complexesKiyotomi Kaneda, Hiroo Kurosaki, Masami Terasawa, Toshinobu Imanaka, and Shiichiro TeranishiCite this: J. Org. Chem. 1981, 46, 11, 2356–2362Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://pubs.acs.org/doi/10.1021/jo00324a029https://doi.org/10.1021/jo00324a029research-articleACS PublicationsRequest reuse permissionsArticle Views378Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comportamento alimentar e hábitos de vida de universitários com migrânea na pandemia da COVID-19 (2021)

Introdução A migrânea é um tipo de cefaleia de origem multifatorial e é considerada uma doença incapacitante. A pandemia da COVID-19 provocou alterações nos hábitos de vida e padrão alimentar da população, que são importantes gatilhos para as crises migranosas. Objetivo Avaliar o impacto das mudanças no estilo de vida e alimentação impostas pela pandemia da COVID-19 quanto à ocorrência de enxaqueca em universitários. Material e Métodos Estudo transversal, retrospectivo, com abordagem descritiva, realizado com acadêmicos de uma universidade de Salvador, Bahia, no período de 12/2020 a 06/2021. Os universitários foram convocados por meio do aplicativo Whatsapp® e, posteriormente, direcionados via link para acesso ao termo de consentimento livre e esclarecido, que foi preenchido, assim como o questionário, via aplicativo de gerenciamento de pesquisa. Esta pesquisa foi aprovada pelo Comitê de Ética em Pesquisa, sob parecer no 4.351.573. Os dados foram analisados por meio de estatística descritiva. Resultados e Discussões: Amostra constituída por 83 indivíduos, 89,2% mulheres, 45,8% sedentários, 51,8% relataram aumento de peso nos últimos meses e 59% têm dificuldade para conciliar o sono. Antes da pandemia, 7,3% relataram 7-14 dias de enxaqueca por mês e, após, identificou-se aumento para 24,1%. Além disso, 36,1% dos acadêmicos associaram algum alimento às crises de enxaqueca, sendo os gatilhos mais comuns: café (20,5%), chocolate (14,5%), embutidos (12%), bebidas alcóolicas (9,6%) e açúcar (6%). Diante dos resultados, percebe-se que a pandemia implicou no aumento do número de dias com enxaqueca por mês, o que pode estar associado às alterações alimentares, à disfunção do sono potencializada pela crise sanitária, aumento de peso nos últimos meses, assim como devido à prevalência de sedentarismo observada. Conclusões As mudanças no estilo de vida e no comportamento alimentar ocasionadas pela pandemia da COVID-19 repercutiu no aumento de dias com enxaqueca por mês em universitários.
Ionization Constants of Acids and Bases (2010)

The use of two or more standard reference solutions may disclose small inconsistencies in the standardization of the pH meter, depending on which standards are chosen. When this is the case, the best results are often obtained by assuming linearity between E and pH between the two calibrating points bracketing the pH of the unknown.
Decarboxylation studies on 3,5-dihydroxyhomophthalic acid derivatives (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDecarboxylation studies on 3,5-dihydroxyhomophthalic acid derivativesRichard N. Hurd and Dinubhai H. ShahCite this: J. Org. Chem. 1973, 38, 3, 610–612Publication Date (Print):February 1, 1973Publication History Published online1 May 2002Published inissue 1 February 1973https://pubs.acs.org/doi/10.1021/jo00943a043https://doi.org/10.1021/jo00943a043research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficacy of Xiaoyusan in the treatment of patients with acute soft tissue injuries (2006)

Objective: To evaluate the clinical efficacy of Xiaoyusan in the treatment of patients with acute soft tissue injuries.Methods: Patients with acute soft tissue injuries were divided into two groups: 35 cases in treatment group were treated with Xiaoyusan one paste per day and 32 cases in control group were treated with diclofenac diethylamine emulgel(Votalin emulgel) 3-4 times/d external application.The period of treatment was 7 days.Symptoms such as local pain,tenderness,swelling,functional disturbance,myospasm and cutaneous burning sensation were observed and compared.Results: Both Xiaoyusan and diclofenac diethylamine emulgel had good efficacy in treatment of acute soft tissue injuries.There was no statistically significant difference in total efficacy between the two groups.Xiaoyusan had better efficacy in relieving myospasm and swelling than those with diclofenac diethylamine emulgel,but diclofenac diethylamine emulgel had better efficacy in relieving cutaneous burning sensation than that with Xiaoyusan.Conclusion: Xiaoyusan has good efficacy in treatment of acute soft tissue injuries.
Review of Active IR Thermography for Detection and Characterization of Defects in Reinforced Concrete (2016)

Active thermography methods enable structural investigations of reinforced concrete elements taking into account many different testing problems. The goal of this review is to provide an overview on the state-of-the-art regarding the use of active infrared thermography (IRT) for detection and characterization of defects in reinforced concrete. The paper will provide the physical background, equipment being used, as well as post-processing methods that are used to analyse sequences of thermograms. This work also presents the fields of applicability of IRT with a focus on the aspects related to reinforced concrete structures, as well as the advantages, limitations and potential sources of errors of IRT employment. Additionally previous non-destructive testing (NDT) studies that employed thermography techniques with natural excitation are briefly presented. A review of the future trends of thermal imaging are also included in this work. It can be concluded that while IRT is a useful tool for the characterisation of defects in the building sector, there is great prospect for the development of more advanced, effective and accurate approaches that will employ a combination of thermography approaches.
Aft Anode Sled Failure at a Floating Production Unit Hull (2007)

Abstract An Impressed Current Cathodic Protection (ICCP) with remote anodes on the seabed was installed on the Zafiro Producer, a floating production facility to extend the vessel hull life. Seven months after the installation, the aft anode sled suddenly failed. Subsea components of the anode sled were retrieved and exhibited severe metal loss and high temperature exposure. The investigation team determined that a lightning strike was the most likely cause of failure. This paper discusses how a lightning strike to the floating production unit damaged the remote anode sled on the seabed.
Biodiesel Fuels through a Continuous Flow Process of Chicken Fat Supercritical Transesterification (2009)

Supercritical transesterification of chicken fat with methanol was investigated at various temperatures (350, 375, and 400 °C), pressures (100, 200, and 300 bar), methanol-to-chicken-fat molar ratios (from stoichiometric 3:1 to 12:1), and residence times (3−10 min). The best experimental results for the conversion of triglycerides and the decomposition of glycerol to fuel components were obtained under the following conditions: 400 °C, 300 bar, methanol-to-triglycerides molar ratio = 9:1, and residence time = 6 min. The thermal decomposition products of long-chain methyl esters and glycerol were identified in the biodiesel samples and their potential influence on fuel characteristics such as viscosity, cold flow, cetane number, and flash point is discussed. Because of the low excess of methanol used in this study in comparison with similar supercritical transesterification processes (methanol-to-feedstock molar ratios of 3−12 vs 40+), costs associated with the pumping, preheating, and recovery of the excess methanol will be greatly reduced in commercial applications. Use of low-cost feedstocks and a moderate excess of methanol, coupled with glycerol decomposition to valuable fuel components, certainly will increase the profitability of a much simplified method, in comparison with competitive technologies.
Noise source location techniques: Simple to advanced applications (2003)

There are several noise source location techniques available to engineers working on Noise, Vibration and Harshness (NVH) problems. Choosing the right technique depends on the application, as well as the information required. This article reviews techniques for noise source location and quantification applications, including the relatively new beamforming method. An innovative beamformer microphone array is also presented and compared to traditional array designs and performances. Modern noise source location techniques are extremely valuable tools in mechanical engineering industries. It is important to understand the acoustic behavior of structures in the automotive and aerospace industries, as noise investigations are crucial for regulations and research and development. Furthermore, it is important to be able to locate and quantify noise sources with reliable, fast and accurate techniques. Due to the excellent performance of modern computers and advances in acoustics sciences, many new tools are available that can be used by any NVH engineer. This article presents a review of the following noise source location techniques: Sound pressure mapping. Sound intensity and selective intensity. Near-field acoustic holography. Non-stationary acoustic holography. Beamforming (phased array technique). Inverse Boundary Element Methods (IBEM).
One-hot residue coding for low delay-power product CMOS design (1998)

CMOS implementations of arithmetic circuits for One-Hot Residue (OHR) encoded operands are presented. They are shown to possess SPICE-simulated delay-power (DP) products that are significantly reduced below those of their binary number system counterparts (ripple-carry adder and Wallace tree multiplier). The reduction is attributable to the one-hot representation, which decreases the number of critical path transistors and signal activity factors. An OHR-based direct digital frequency synthesizer for frequency-hopped communication systems is presented, and analytical estimates of its DP-product are derived. The design exhibits a DP-product reduction in excess of 90% below that of a binary-encoded residue synthesizer.
Binding and Suppression of the Myc Transcriptional Activation Domain by p107 (1994)

An amino-terminal transactivation domain is required for Myc to function as a transcription factor controlling cell proliferation, differentiation, and apoptosis. A complementary DNA expression library was screened with a Myc fusion protein to identify proteins interacting with this domain, and a clone encoding the Rb-related p107 protein was isolated. The p107 protein was shown to associate with Myc in vivo and to suppress the activity of the Myc transactivation domain. However, mutant forms of Myc from Burkitt lymphoma cells, which contain sequence alterations in the transactivation domain, were resistant to p107-mediated suppression. Thus, disruption of a regulatory interaction between Myc and p107 may be important in tumorigenesis.
Mitigating SMS spam by online detection of repetitive near-duplicate messages (2012)

Short Message Service (SMS) spam is increasingly becoming a problem for many telecommunication service providers. Not only do SMS spam messages use mobile network resources abusively, but also in many cases they represent malware propagation vectors for mobile devices. In this work, we propose a network-based online detection method for SMS spam messages. The proposed scheme uses robust text signatures to identify similar messages that are sent excessively in the SMS platform and is robust against slight modifications in SMS spam messages. Additionally, the method uses a fast online algorithm which can be deployed in large carrier networks to detect spam activities before too many spam messages are delivered. It does not store SMS message contents, therefore it does not compromise the privacy of mobile subscribers.