gebhart/patrepeval huggingface dataset:
Self-Assembly of Cetyl Linear Polyethylenimine To Give Micelles, Vesicles, and Dense Nanoparticles (2004)

The involvement of macromolecules in the formation of biological and other membranes has important implications for structural biology and nanoengineering. Using cetyl polyethylenimines of varying molecular weight and hydrophobicity, it was found that polymer hydrophobicity (mol % cetylation) controlled the nature of the self-assembly, giving micellar (cetyl groups < 23 mol %), vesicular (cetyl groups = 23−42 mol % or cetyl groups = 3−42 mol % with cholesterol), and dense nanoparticle (cetyl groups ≥ 49 mol %) aggregates. Thick (up to 15 nm) membranes due to the polyelectrolyte coating with the amphiphile were observed with low levels of cetylation only, and both dn/dc (indirectly) and vesicle/nanoparticle size (directly) varied linearly with mol % cetylation (r = 0.96−0.99).
Facile Total Synthesis of Benzo[<i>b</i>]furan Natural Product XH-14 (2009)

Abstract An efficient and practical total synthesis of benzo[b]furan natural product XH-14 is demonstrated in nine steps from vanillin. Introduction of iodide substituents in the reaction including optimization of the reaction sequences is essential for the successful synthesis of XH-14. Sonogashira coupling with iodobenzene, iodine-induced cyclization, Wittig reaction, and formylation are critical in the high-yield total synthesis of XH-14.
World Wide Database—integrating the Web, CORBA and databases (1999)

article Free Access Share on World Wide Database—integrating the Web, CORBA and databases Authors: Athman Bouguettaya Queensland University of Technology, School of Information Systems GPO Box 2434 Brisbane, QLD, 4001 Australia Queensland University of Technology, School of Information Systems GPO Box 2434 Brisbane, QLD, 4001 AustraliaView Profile , Boualem Benatallah Queensland University of Technology, School of Information Systems GPO Box 2434 Brisbane, QLD, 4001 Australia Queensland University of Technology, School of Information Systems GPO Box 2434 Brisbane, QLD, 4001 AustraliaView Profile , Lily Hendra Queensland University of Technology, School of Information Systems GPO Box 2434 Brisbane, QLD, 4001 Australia Queensland University of Technology, School of Information Systems GPO Box 2434 Brisbane, QLD, 4001 AustraliaView Profile , James Beard Queensland University of Technology, School of Information Systems GPO Box 2434 Brisbane, QLD, 4001 Australia Queensland University of Technology, School of Information Systems GPO Box 2434 Brisbane, QLD, 4001 AustraliaView Profile , Kevin Smith Queensland University of Technology, School of Information Systems GPO Box 2434 Brisbane, QLD, 4001 Australia Queensland University of Technology, School of Information Systems GPO Box 2434 Brisbane, QLD, 4001 AustraliaView Profile , Mourad Quzzani Queensland University of Technology, School of Information Systems GPO Box 2434 Brisbane, QLD, 4001 Australia Queensland University of Technology, School of Information Systems GPO Box 2434 Brisbane, QLD, 4001 AustraliaView Profile Authors Info & Claims ACM SIGMOD RecordVolume 28Issue 2June 1999 pp 594–596https://doi.org/10.1145/304181.304589Online:01 June 1999Publication History 4citation577DownloadsMetricsTotal Citations4Total Downloads577Last 12 Months4Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder (2015)

Mutations that reduce expression or give rise to a Thr85Ser (T85S) mutation of Ca(2+)-CaM-dependent protein kinase kinase-2 (CaMKK2) have been implicated in behavioural disorders such as anxiety, bipolar and schizophrenia in humans. Here we report that Thr85 is an autophosphorylation site that endows CaMKK2 with a molecular memory that enables sustained autonomous activation following an initial, transient Ca(2+) signal. Conversely, autophosphorylation of Ser85 in the T85S mutant fails to generate autonomous activity but instead causes a partial loss of CaMKK2 activity. The loss of autonomous activity in the mutant can be rescued by blocking glycogen synthase kinase-3 (GSK3) phosphorylation of CaMKK2 with the anti-mania drug lithium. Furthermore, CaMKK2 null mice representing a loss of function model the human behavioural phenotypes, displaying anxiety and manic-like behavioural disturbances. Our data provide a novel insight into CaMKK2 regulation and its perturbation by a mutation associated with behavioural disorders.
Isothermal Vapor−Liquid Equilibria for the Systems 1-Chloro-1,1-difluoroethane + Hydrogen Fluoride, 1,1-Dichloro-1-fluoroethane + Hydrogen Fluoride, and Chlorodifluoromethane + Hydrogen Fluoride (1997)

Isothermal vapor−liquid equilibria for the three binary systems (1-chloro-1,1-difluoroethane + hydrogen fluoride, 1,1-dichloro-1-fluoroethane + hydrogen fluoride, and chlorodifluoromethane + hydrogen fluoride) have been measured. The experimental data for the binary systems are correlated with the NRTL equation with the vapor-phase association model for the mixtures containing hydrogen fluoride, and the relevant parameters are presented. All of the systems form minimum boiling heterogeneous azeotropes.
An effective CIC (co-channel interference canceller) scheme for multi-rate CDMA (2002)

This paper proposes an improved CIC scheme for lessening noise enhancement extended from SD (soft decision)-based parallel cancellation. The scheme is effective especially in multi-rate CDMA. Its hardware is more complex than that of conventional SD-based CIC, but it is still less than that of the HD (hard decision)-based CIC with channel estimators. Because the processing delay is as small as that of the conventional SD-based CIC, TPC (transmission power control) can be performed immediately, based on the measured SIR after interference cancellation in the proposed CIC as well as in the conventional SD-based CIC. Our computer simulation shows that the capacity normalized by the processing gain is 0.50 without interference cancellation, 0.70 with conventional SD-based CIC, and 0.83 with the proposed CIC, at 8 dB of the required S/N for 0.1% BER by one CIC stage.
Microwave Electronics: Measurement and Materials Characterization (2004)

Preface.1. Electromagnetic Properties of Materials.2. Microwave Theory and Techniques for Materials Characterization.3. Reflection Methods.4. Transmission/Reflection Methods.5. Resonator Methods.6. Resonant-perturbation Methods.7. Planar-circuit Methods.8. Measurements of Permittivity and Permeability Tensors.9. Measurement of Ferroelectric Materials.10. Microwave Measurement of Chiral Materials.11. Measurement of Microwave Electrical Transport Properties.12. Measurement of Dieletric Properties of Materials at High Temperatures.Index.
AudioGPS: spatial audio in a minimal attention interface (2001)

In this paper we consider a prototype audio user interface for a Global Positioning System (GPS) that is designed to allow mobile computer users to carry out a location task while their eyes, hands and attention are often otherwise engaged. Audio user interfaces for GPS have typically been designed to meet the needs of visually handicapped users, and generally (though not exclusively) employ speech-audio. In this paper, we consider a prototype audio GPS user interface designed primarily for sighted mobile computer users who may have to attend simultaneously to other tasks, and who may be holding conversations at the same time. The system is considered in the context of being one component of a user interface for mobile computer users. The prototype system uses a simple form of spatial audio. Various candidate audio mappings of location and distance information are analysed. A variety of tasks, design considerations, technological opportunities and design trade-offs are considered. Preliminary findings are reported. Opportunities for improvements to the system, and future empirical testing are explored.
Verification of composite Galois field multipliers over GF ((2<sup>m</sup>)<sup>n</sup>) using computer algebra techniques (2011)

Galois field computations abound in many applications, such as in cryptography, error correction codes, signal processing, among many others. Multiplication usually lies at the core of such Galois field computations, and is one of the most complex operations. Hardware implementations of such multipliers become very expensive. Therefore, there have been efforts to reduce the design complexity by decomposing the Galois field GF(2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</sup> ) as GF ((2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sup> ) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</sup> ) where k = m × n. Such a decomposition introduces a hierarchical abstraction - lifting the ground field from GF (2) (bit-level) to GF (2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sup> ) (word-level) - thus simplifying the design. This paper addresses the formal verification problem of such multipliers designed over GF ((2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sup> ) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</sup> ), using a computer algebra and algebraic geometry based approach. To prove that the composite field multiplier implementation matches the original specification, we hierarchically formulate the verification problem using the Hilbert's Nullstellensatz over Galois Fields. A Gröbner basis engine is employed as the underlying computational framework. Experiments are performed with various variable/term orders to demonstrate the efficacy of our approach. We can verify the correctness of upto 1024bit multipliers, whereas SAT/SMT-based approaches are in-feasible.
Studies on Aromatase Inhibitors IV. Synthesis and Biological Evaluation of N,N-Disubstituted-5-aminopyrimidine Derivatives. (1997)

In order to study the potency of the 5-aminopyrimidine skeleton as an aromatase inhibitor, we synthesized various N,N-disubstituted-5-aminopyrimidine derivatives and evaluated their aromatase-inhibitory activity (in vitro) and their inhibitory activity on pregnant mare serum gonadotropin (PMSG)-induced estrogen synthesis (in vivo). Compounds with the fluoro-substituted benzyl group showed potent aromatase inhibition. Among them, 5-[(4-cyanophenyl)(3,5-difluorobenzyl)amino]pyrimidine (5w, YM553) was a highly potent compound with an IC50 value of 0.038 nM for aromatase from human placenta. Its inhibitory effect was approximately four times greater than that of YM511. In addition, YM553 was a weak inhibitor of other enzymes involved in steroid hormone synthesis. These results indicate that YM553, as well as YM511 (a 4-amino-4H-1,2,4-triazole derivative), is a promising agent for the treatment of estrogen-dependent diseases.
Safe Distributed Lane Change Maneuvers for Multiple Autonomous Vehicles Using Buffered Input Cells (2018)

This paper introduces the Buffered Input Cell as a reciprocal collision avoidance method for multiple vehicles with high-order linear dynamics, extending recently proposed methods based on the Buffered Voronoi Cell [1] and generalized Voronoi diagrams [2]. We prove that if each vehicle's control input remains in its Buffered Input Cell at each time step, collisions will be avoided indefinitely. The method is fast, reactive, and only requires that each vehicle measures the relative position of neighboring vehicles. We incorporate this collision avoidance method as one layer of a complete lane change control stack for autonomous cars in a freeway driving scenario. The lane change control stack comprises a decision-making layer, a trajectory planning layer, a trajectory following feedback controller, and the Buffered Input Cell for collision avoidance. We show in simulations that collisions are avoided with multiple vehicles simultaneously changing lanes on a freeway. We also show in simulations that autonomous cars using the BIC method effectively avoid collisions with an aggressive human-driven car.
Effect of modulators on 5-fluorouracil metabolite patterns in murine colon carcinoma determined by in vitro 19F nuclear magnetic resonance spectroscopy. (1994)

High-resolution 19F nuclear magnetic resonance spectroscopy at 7 T was used to study the effect of modulators on the metabolism of 5-fluorouracil (5-FUra, 115 mg/kg i.p.) in C38 murine colon tumors grown in C57BL/6 mice. Distinct 5-FUra metabolite patterns were found in perchloric acid extracts of these tumors after treatment. The 19F nuclear magnetic resonance spectra exhibited resonances representing 5-FUra, the catabolites alpha-fluoro-beta-ureidopropionic acid and alpha-fluoro-beta-alanine, as well as four distinct fluoronucleotide anabolites. Using this model system the effect of several modulators on 5-FUra tumor metabolite patterns was investigated: methotrexate (300 mg/kg); alpha-interferon (10(5) IU/animal); N-(phosphonacetyl)-L-aspartate (100 and 250 mg/kg); and leucovorin (300 and 750 mg/kg). A significant increase in the anabolite:catabolite ratio was observed for the groups treated with 5-FUra in combination with the modulators methotrexate (n = 8), alpha-interferon (n = 7), and high-dose leucovorin (n = 14), but not for low-dose leucovorin (n = 7). Cotreatment with high-dose N-(phosphonacetyl)-L-aspartate (n = 8) resulted in a significant decrease in the anabolite: catabolite ratio compared to treatment with 5-FUra alone (n = 16). Possible correlations of metabolite profiles with therapy response are discussed.
Deterministic characterization of stochastic genetic circuits (2007)

For cellular biochemical reaction systems where the numbers of molecules is small, significant noise is associated with chemical reaction events. This molecular noise can give rise to behavior that is very different from the predictions of deterministic rate equation models. Unfortunately, there are few analytic methods for examining the qualitative behavior of stochastic systems. Here we describe such a method that extends deterministic analysis to include leading-order corrections due to the molecular noise. The method allows the steady-state behavior of the stochastic model to be easily computed, facilitates the mapping of stability phase diagrams that include stochastic effects, and reveals how model parameters affect noise susceptibility in a manner not accessible to numerical simulation. By way of illustration we consider two genetic circuits: a bistable positive-feedback loop and a negative-feedback oscillator. We find in the positive feedback circuit that translational activation leads to a far more stable system than transcriptional control. Conversely, in a negative-feedback loop triggered by a positive-feedback switch, the stochasticity of transcriptional control is harnessed to generate reproducible oscillations.
Metal‐Enhanced Fluorescence: Progress Towards a Unified Plasmon‐Fluorophore Description (2010)

Summary This chapter contains sections titled: Introduction Metal-Enhanced Fluorescence (MEF) Metal-Enhanced Chemiluminescence (MEC) Metal-Enhanced Phosphorescence (MEP) Closing Remarks Acknowledgments
The Evolving Role of Docetaxel in the Management of Androgen Independent Prostate Cancer (2003)

Docetaxel based regimens are moderately well tolerated and they have shown promising results in various phase 2 trials. The completion of ongoing phase III randomized trials are eagerly awaited since they may determine whether a definite beneficial impact on overall survival can be achieved.
Extracting bits from coordinates of a point of an elliptic curve. (2005)

In the classic Di#e-Hellman protocol based on a generic group G, Alice and Bob agree on a common secret KAB (master secret) which is indistinguishable from another element of G but not from a random bits-string of the same length. In this paper, we present a new deterministic method to extract bits from KAB when G is an elliptic curve defined over a quadratic extension of a finite field. In the last section, we show that it is also possible to extract a few bits when G is an elliptic curve defined over a prime field.
TERRESTRIAL ISOPODS FROM WEST AFRICA (1985)

SUMMARY In this 4th Part of our review of West African terrestrial isopods 37 species have been studied including the re-examination of the type-specimens of species described by HILGENDORF, BUDDE-LUND and VERHOEFF. Two genera Leonoscia (Philosciidae) and Congethelum (Eubelidae) and 10 species are new. An identification key for all the genera treated is given together with comments on the distribution and ecology of the West African isopod fauna.
Formal specification in collaborative design of critical software tools (2002)

Engineers use software tools to analyze designs for critical systems. Because important decisions are based on tool results, tools must provide valid modeling constructs, engineers must understand them to validate their models; and tools must be implemented without major error. Such tools thus demand careful conceptual and software design. One aspect of such design is the use of rigorous specification and design techniques. This paper contributes a case study on the use of such techniques in the collaborative development of a dynamic fault tree analysis tool. The collaboration involved software engineering researchers knowledgeable in software specification and design and reliability engineering researchers expert in fault tree analysis. Our work revealed conceptual and implementation errors in an earlier version of the tool. Our study supports the position that there is a need for rigorous software specification and design in developing novel analysis tools, and that collaboration between software engineers and domain experts is feasible and profitable.
Features, identity, tracing, and cryptography in product authentication (2007)

Product authentication is needed in anti-counterfeiting to distinguish genuine products from counterfeit ones. In spite of the current availability of sophisticated techniques and solution concepts for product authentication, secure authentication of different kinds of physical products remains an unsolved problem in practice. This paper presents a systematic overview of product authentication techniques. Our goal is to identify and analyze fundamental approaches for product authentication, investigate the available and emerging technologies and to evaluate them. The results are used to derive a set of decision variables, or constraints, that need to be taken into consideration when choosing which approach is most suitable to authenticate a given product.
Reactions of Sulfur Containing Phenolic Antioxidants for Elastomers (1999)

Abstract Alkyl-hydroxybenzylthioethers are efficient storage and processing stabilizers for elastomers and adhesives. Especially alkyl-(2-hydroxybenzyl)thioethers represent an intramolecular combination of a primary and secondary antioxidant, i.e. a phenolic and a thioether moiety in an optimized spatial arrangement. The mechanism of their intramolecular synergism was investigated. The best overall stabilizers are 2,4-bis(alkylthiomethyl)-6-methylphenols, e.g. AOl, in contrast to 2,6-dialkyl-4-alkylthiomethylphenols(B), 4-alkyl-2,6-bis(alkylthiomethyl)phenols C.
Inhibition of Growth of Experimental Human and Hamster Pancreatic Cancers In Vivo by a Targeted Cytotoxic Bombesin Analog (2005)

Bombesin/GRP receptors are expressed on most ductal pancreatic carcinoma cell lines and can be used for targeted chemotherapy with the cytotoxic bombesin analog AN-215.
Bioperformance of shape memory alloy single crystals. (2006)

Shape memory alloys (SMA) represent a large family of alloys that show unique characteristics. They have been exploited in several fields for diverse applications. For the last 20 years, these alloys and more particularly Ni-Ti alloys have revolutionized the field of metallic biomaterials. Applications in the biomedical area are multiple and these materials improve significantly the quality of the diagnostics, treatments and surgeries. To our knowledge, most devices are made of SMAs in the polycrystalline form. Nevertheless, the single crystal form shows several promising advantages especially concerning its mechanical performances. In this paper we describe the advantages, advances and limits of using different SMA single crystals for biomedical applications, including biocompatibility and corrosion resistance. We also discuss the low response time of classical thermal SMAs as well as the new advances in research on magnetic SMA single crystals.
Memantine for Alcohol Dependence: An Open-label Pilot Study (2007)

Background Glutamatergic function, particularly that mediated by the N-methyl-D-aspartate (NMDA) receptor, has been implicated in the pathophysiology of alcohol dependence. Preclinical and human laboratory studies of memantine, an NMDA-receptor channel blocker, suggest that it may reduce alcohol consumption. Methods We conducted an 8-week, open-label study of memantine to examine its potential utility in promoting reduced drinking or abstinence in 20 alcohol-dependent individuals (mean age=50.1 y, 12 women). Memantine was administered orally, initially at a dosage of 5 mg/d, with weekly increases of 5 mg/d to a target dosage of 20 mg/d. Subjects also received 7 coping skills therapy sessions. Results Most subjects (n=16 or 80%) achieved the maximal dosage and completed treatment (n=17 or 85%). Memantine was generally well tolerated, with no serious adverse events. During the course of the study, subjects reported significantly reduced drinking days, heavy drinking days, and mean drinks/wk, and also reduced urge to drink and alcohol-related consequences (all P's<0.02). Conclusions Memantine at a dosage of 20 mg/d is well tolerated in alcohol-dependent individuals. Because it is not possible from this study to draw a firm conclusion regarding the efficacy of memantine to reduce drinking, further evaluation of the medication as a treatment for alcohol dependence is warranted.
Sheathless Capillary Electrophoresis/Electrospray Mass Spectrometry Using a Carbon-Coated Fused-Silica Capillary (1999)

A simple procedure was developed for preparing a carbon-coated fused-silica capillary for use in sheathless capillary electrophoresis/electrospray mass spectrometry (CE/ESI-MS). The tapered capillary tip was smeared with a marker pen before coating with carbon using a soft pencil. The layer from the ink of the marker pen was critical to the preparation of the carbon-coated capillary. The fabrication of a carbon-coated fused-silica capillary tip requires less than 1 min. The stability of this carbon-coated fused-silica capillary is examined, and its utility in on-line sheathless CE/ESI-MS is demonstrated with the separation of berberine, coptisine, and palmatine chlorides. Although the carbon-coated fused-silica capillary tip is not as rugged as a gold-coated capillary, it is durable enough for sheathless CE/ESI-MS applications. Moreover, it is easy to refurbish the column once the performance of the tip is degraded.