gebhart/patrepeval huggingface dataset:
Tree-CNN: A Deep Convolutional Neural Network for Lifelong Learning (2018)

In recent years, Convolutional Neural Networks (CNNs) have shown remarkable performance in many computer vision tasks such as object recognition and detection. However, complex training issues, such as catastrophic forgetting and hyper-parameter tuning, make incremental learning in CNNs a difficult challenge. In this paper, we propose a hierarchical deep neural network, with CNNs at multiple levels, and a corresponding training method for lifelong learning. The network grows in a tree-like manner to accommodate the new classes of data without losing the ability to identify the previously trained classes. The proposed network was tested on CIFAR-10 and CIFAR-100 datasets, and compared against the method of fine tuning specific layers of a conventional CNN. We obtained comparable accuracies and achieved 40% and 20% reduction in training effort in CIFAR-10 and CIFAR 100 respectively. The network was able to organize the incoming classes of data into feature-driven super-classes. Our model improves upon existing hierarchical CNN models by adding the capability of self-growth and also yields important observations on feature selective classification.
Membrane sialoglycolipids emerging as possible signal transducers for lymphocyte stimulation. (1981)

Biotin hydrazide was attached covalently to the aldehyde groups produced by periodate oxidation of bovine brain gangliosides. These modified gangliosides were incorporated into mature rat thymocytes by incubation of the biotinyl gangliosides in the culture medium containing these cells. Avidin, which binds strongly to biotin, agglutinated and stimulated DNA synthesis in thymocytes containing the incorporated biotin-tagged gangliosides. Avidin has no mitogenic effect on normal thymocytes or on cells that incorporate unmodified gangliosides. With fluoresceinated avidin, the incorporated biotinyl gangliosides are shown to be laterally redistributed into patches and caps. These results imply that gangliosides may be involved in transmembrane communication during lymphocyte stimulation.
Analysis of UVB‐modulated Gene Expression in Human Keratinocytes by mRNA Differential Display Polymerase Chain Reaction (1997)

Ultraviolet (UV) light is the most important environmental insult to skin. Even a single exposure to UVB radiation can result in inflammation and may also lead to DNA damage and apoptosis in the acute response of the cutaneous tissue. To elucidate the complex alterations of gene expression in human keratinocytes underlying these UV responses we took advantage of differential display polymerase chain reaction (DD-PCR) technology's ability to detect qualitative and quantitative changes in gene expression in more than two cell populations simultaneously. We demonstrate that low-dose UVB (100 Jm-2) leads to both induction and downregulation of different genes during the 24 h after irradiation in a time-dependent manner. In addition to the identification of known genes as possible effectors or targets in the UV response of human keratinocytes, we here identify a new sequence that is negatively regulated by UVB irradiation and was termed HUR 7 (HaCaT UV repressed). In general our results showed that DD-PCR is a useful tool in the analysis of quantitative changes of mRNA levels in human keratinocytes after UV irradiation. The identification of new UVB-repressed genes offers the opportunity to identify unrecognized molecular mechanisms in the UV response of human cells.
GALE (1941)

GALE Get access T. O. Robinson T. O. Robinson Search for other works by this author on: Oxford Academic Google Scholar English: Journal of the English Association, Volume 3, Issue 16, Spring 1941, Pages 176-c–176, https://doi.org/10.1093/english/3.16.176-c Published: 01 March 1941
Unsupervised morphological segmentation and clustering with document boundaries (2009)

Many approaches to unsupervised morphology acquisition incorporate the frequency of character sequences with respect to each other to identify word stems and affixes. This typically involves heuristic search procedures and calibrating multiple arbitrary thresholds. We present a simple approach that uses no thresholds other than those involved in standard application of X2 significance testing. A key part of our approach is using document boundaries to constrain generation of candidate stems and affixes and clustering morphological variants of a given word stem. We evaluate our model on English and the Mayan language Uspanteko; it compares favorably to two benchmark systems which use considerably more complex strategies and rely more on experimentally chosen threshold values.
Multichannel parallel data link for optical communication (1991)

The MODLINK (multichannel parallel optical data link) system is described. It provides 12 parallel data channels; one channel may be used for clock signal, and provisions are made for synchronizing the data channels with the clock. Additional MODLINK units can be linked in parallel for more channels. The system can handle data rates from DC to 200 Mb/s/channel in continuous or burst mode. Since this system is burst-mode compatible, data signal encoding is not required and clock recovery is optional. The transmitter and receiver systems are presented in detail. System performance is examined with respect to the thermal characteristics of the transmitter package, interchannel crosstalk in the transmitter, receiver sensitivity and interchannel crosstalk, and long-distance transmission.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Organogold oligomers: exploiting iClick and aurophilic cluster formation to prepare solution stable Au<sub>4</sub> repeating units (2015)

A novel synthetic method to create gold based metallo-oligomers/polymers via the combination of inorganic click (iClick) with intermolecular aurophilic interactions is demonstrated. Complexes [PEt3Au]4(μ-N3C2C6H5) (1) and [PPhMe2Au]4(μ-N3C2C6H5) (2) and {[PEt3Au]4[(μ-N3C2)2-9,9-dihexyl-9H-fluorene]}n (8) have been synthesized via iClick. The tetranuclear structures of 1 and 2, induced by aurophilic bonding, are confirmed in the solid state through single crystal X-ray diffraction experiments and in solution via variable temperature NMR spectroscopy. The extended 1D structure of 8 is constructed by aurophilic induced self-assembly. (1)H DOSY NMR analysis reveals that the aurophilic bonds in 1, 2, and 8 are retained in the solution phase. The degree of polymerization within complex 8 is temperature and concentration dependent, as determined by (1)H DOSY NMR. Complex 8 is a rare example of a solution stable higher ordered structure linked by aurophilic interactions.
An Improved Batch Means Procedure for Simulation Output Analysis (2002)

We formulate and evaluate the Automated Simulation Analysis Procedure (ASAP), an algorithm for steady-state simulation output analysis based on the method of nonover-lapping batch means (NOBM). ASAP delivers a confidence interval for an expected response that is centered on the sample mean of a portion of a simulation-generated time series and satisfies a user-specified absolute or relative precision requirement. ASAP operates as follows: The batch size is progressively increased until either (a) the batch means pass the von Neumann test for independence, and then ASAP delivers a classical NOBM confidence interval; or (b) the batch means pass the Shapiro-Wilk test for multivariate normality, and then ASAP delivers a correlation-adjusted confidence interval. The latter adjustment is based on an inverted Cornish-Fisher expansion for the classical NOBM t-ratio, where the terms of the expansion are estimated via an autoregressive-moving average time series model of the batch means. After determining the batch size and confidence-interval type, ASAP sequentially increases the number of batches until the precision requirement is satisfied. An extensive experimental study demonstrates the performance improvements achieved by ASAP versus well-known batch means procedures, especially in confidence-interval coverage probability.
Interactions between small ankyrin 1 and sarcolipin coordinately regulate activity of the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1) (2017)

SERCA1, the sarco(endo)plasmic reticulum Ca<sup>2+</sup>-ATPase of skeletal muscle, is essential for muscle relaxation and maintenance of low resting Ca<sup>2+</sup> levels in the myoplasm. We recently reported that small ankyrin 1 (sAnk1) interacts with the sarco(endo)plasmic reticulum Ca<sup>2+</sup>-ATPase in skeletal muscle (SERCA1) to inhibit its activity. We also showed that this interaction is mediated at least in part through sAnk1's transmembrane domain in a manner similar to that of sarcolipin (SLN). Earlier studies have shown that SLN and phospholamban, the other well studied small SERCA-regulatory proteins, oligomerize either alone or together. As sAnk1 is coexpressed with SLN in muscle, we sought to determine whether these two proteins interact with one another when coexpressed exogenously in COS7 cells. Coimmunoprecipitation (coIP) and anisotropy-based FRET (AFRET) assays confirmed this interaction. Our results indicated that sAnk1 and SLN can associate in the sarcoplasmic reticulum membrane and after exogenous expression in COS7 cells <i>in vitro</i> but that their association did not require endogenous SERCA2. Significantly, SLN promoted the interaction between sAnk1 and SERCA1 when the three proteins were coexpressed, and both coIP and AFRET experiments suggested the formation of a complex consisting of all three proteins. Ca<sup>2+</sup>-ATPase assays showed that sAnk1 ablated SLN's inhibition of SERCA1 activity. These results suggest that sAnk1 interacts with SLN both directly and in complex with SERCA1 and reduces SLN's inhibitory effect on SERCA1 activity.
Falling in place (2001)

Learning to fall: the blessings of an imperfect life Philip Simmons Sandwich (NH): Homefarm Books; 2001 155 pp US$25 (cloth) ISBN 0-73884021-1 US$16 (paper) ISBN 0-7388-4022-X

Mrs. R. looked tired, yet her eyes were piercing and her voice determined. “Bal, I need a new way of looking at all of
Whole Brain Radiotherapy and RRx-001: Two Partial Responses in Radioresistant Melanoma Brain Metastases from a Phase I/II Clinical Trial (2016)

Metastatic melanoma to the brain is historically associated with poor outcomes and a median survival of 4 to 5 months. WBRT is a mainstay of treatment for patients with multiple brain metastases, but no significant therapeutic advances for these patients have been described in the literature. To date, candidate radiosensitizing agents have failed to demonstrate a survival benefit in patients with brain metastases, and in particular, no agent has demonstrated improved outcome in patients with metastatic melanoma. Kim et al. report two patients with melanoma metastases to the brain that responded to treatment with novel radiosensitizing agent RRx-001 and WBRT without neurologic or systemic toxicity in the context of a phase I/II clinical trial.
Abstract 5744: The role of atypical protein kinase C in colorectal cancer cell growth and proliferation (2017)

Abstract Colorectal cancer (CRC) is the second most common cancer in the world and death from colorectal cancer accounts for 8% of all cancer deaths both in men and women in the United States. CRC is life threatening disease due to therapy resistant cancerous cells. The exact mechanisms of cell growth, survival, metastasis and inter & intracellular signaling pathways involved in colon cancer are still a major challenge for scientists. Hence, investigating the signaling pathways that lead to colon carcinogenesis may give insight into the therapeutic target. In this study, the role of atypical Protein kinase C (aPKC) on colon cancer was identified by using four inhibitors of that particular protein class: 1) ACPD (2-acetyl-1,3-cyclopentanedione and 2) DNDA (3,4-diamino-2,7 naphthalenedisulfonic acid) are non-specific inhibitors of aPKCs; 3) ζ-Stat (8-hydroxy-1, 3, 6-naphthalenetrisulfonic acid) is a specific inhibitor of PKC-ζ; and 4) ICA-I (4, 5-amino-4-carbamoylimidazol-1-yl-2, 3-dihydroxycyclopentyl) methyl dihydrogen phosphate) is a specific inhibitor of PKC-ι. The cell lines tested were HT-29 colon cancer and CCD18CO normal colon epithelial. Although PKC-ι is an oncogene in many cancers, we found that the PKC-ζ was responsible for the abnormal growth and proliferation in HT-29 colon cancer cells. Additionally, the inhibition of aPKCs did not bring any significant toxicity on CCD18CO normal colon cell line. These results suggest the potentiality of utilizing aPKC-ζ inhibitors to block colon cancer cell growth and proliferation. Citation Format: S M Anisul Islam, Mildred Acevedo Duncan. The role of atypical protein kinase C in colorectal cancer cell growth and proliferation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5744. doi:10.1158/1538-7445.AM2017-5744
Forcing single‐chain variable fragment production in tobacco seeds by fusion to elastin‐like polypeptides (2006)

Single-chain variable fragments (scFvs), as well as other recombinant antibodies, have become powerful tools for therapy and analysis in both human and veterinary medicine. Transgenic plants have been developed as an efficient production system for these recombinant proteins, achieving high yields at moderate cost. Seeds are especially useful organs for molecular farming because of their high protein content and their ability to keep proteins functional during extended storage in ambient conditions. Several concepts have been applied to optimize protein accumulation in seeds, such as the use of specific promoters and transcription enhancers. In this paper, we present a new strategy to enhance substantially the expression of scFvs in transgenic tobacco seeds, based on C-terminal fusions to elastin-like polypeptides (ELPs). This strategy resulted in a 40-fold increase in scFv accumulation, with levels approaching 25% of total soluble protein. The fusion proteins show specific activities and affinities comparable with the properties of the corresponding scFvs. This strategy thus opens up new ways to improve greatly the production of recombinant antibodies in plant seeds.
The wear characteristics on bearing outer ring of planetary gear in conflux planet gear train of power-shift steering transmission (2011)

Aimed at the bearing outer ring of planetary gear in planetary transmission, the failure mechanism of wear between the planet gear bearing and thrust washer was investigated. The reasons for its failure and ways to reduce wear were also studied. A typical wear failure of bearing outer ring was analyzed in terms of the morphology observation with scanning electron microscopy (SEM), the metallographic analysis on radial cross section and microhardness testing. Through the comprehensive analysis of metallographic structure and microhardness, the temperature distribution of bearing outer ring was obtained. The results showed that the adhesive wear was the main wear type for thrust washer while the fatigue wear was a small part; a great axial force existed in the working mechanism, which lead to big contact stress and speed up wear; the high temperature on the friction surface could reach about 700°C and cause the tempering process in the material; Inadequate cooling effect due to lack of lubrication oil may be another main reason for the high temperature caused by wear.
Experimental study of protective effect of Fufang Danshen on cerebral ischemia in rat. (2007)

Objective To investigate the protective effect of Fufang Danshen on experimental cerebral ischemia in rat and its mechanism.Methods Rats were given intraperitoneal injection of Fufang Danshen for 3 days. 30 minutes after last injection, cerebral ischemic model was induced by ligation of bilateral common carotid arteries. After the completion of therapeutic course (7 days), cerebral water content, cerebral index, SOD activity, MDA and NO contents were measured.Results Fufang Denshen significantly decreased the cerebral water content, cerebral index, MDA and NO content, significantly increased SOD activity.Conclusion Fufang Danshen may protect the cerebrum from ischemic injury by suppressing lipid peroxidation and increasing antioxidase activity.
Differential efficacy of tumor necrosis factor inhibition in the management of inflammatory eye disease and associated rheumatic disease (2001)

TNF inhibitors are well tolerated immunosuppressive medications that may benefit certain subgroups of patients with inflammatory eye disease, but they appear to be more effective in controlling associated inflammatory arthritis.
Integration of fieldbus into DCS (2003)

Control systems have evolved from local control to centralized control to today's distributed control. With the emergence of fieldbus, new control strategies and architectures using this new concept will revolutionize instrumentation and control systems. The paper discusses the advantages of fieldbus, describe its benefits and impacts on distributed control systems (DCSs) and predict the next architectural transformation of control systems based on the current driving force. Also, some of the technical challenges and three approaches of integrating fieldbus into existing DCSs are presented.
Integración de la dimensión ambiental en la formación académica en hospitales del municipio de Holguín (2018)

Introduccion: Las organizaciones hospitalarias actuales deben trazarse como objetivo estrategico desarrollar un personal de alta competencia comprometido con la proteccion medioambiental, debido a la vital importancia de esta tematica para lograr la supervivencia de la humanidad. Por tal motivo, las instituciones hospitalarias en Cuba, especificamente los hospitales “Lucia Iniguez Landin”, “Vlaimir Ilich Lenin” y “Octavio de la Concepcion y la Pedraja”, en el municipio de Holguin, presentan la necesidad de mejorar su desempeno ambiental a traves de la formacion de sus trabajadores, por ser factores claves en el logro del exito organizacional. Objetivo: evaluar la eficacia de la integracion de la dimension ambiental en la formacion de los recursos humanos en los hospitales en el municipio de Holguin. Metodos: Se emplearon los metodos teoricos historico-logico, analitico-sintetico, inductivo-deductivo, sistemico-estructural y metodos estadisticos. Los metodos empiricos fueron encuestas a los trabajadores en los hospitales estudiados, entrevistas a los miembros el departamento de recursos humanos en los hospitales estudiados, observacion participante y consulta de documentos para la recopilacion de la informacion. Resultados: Con la aplicacion de los metodos senalados en los hospitales “Lucia Iniguez Landin”, “Vlaimir Ilich Lenin” y “Octavio de la Concepcion de la Pedraja” del municipio de Holguin, se obtuvo como resultados fundamentales la identificacion y evaluacion de los riesgos ambientales por puestos de trabajo, las competencias ambientales por cargos asociadas a los componentes, los procedimientos ambientales, la evaluacion de la eficacia de la integracion segun los objetivos de la organizacion e individuales, asi como mejoras en los indicadores de desempeno fundamentales. Palabras clave: formacion; dimension ambiental; recursos humanos; hospitales.
Cuarta Revolución Industrial (4RI): las universidades y el papel de los investigadores (2021)

La Cuarta Revolución Industrial (4RI) es una revolución con toda una gestión masiva de datos, marcada por la digitalización de la información sobre las poblaciones y sus historias. El presente artículo ofrece elementos al debate en lo que respecta a la 4RI, su vínculo con las universidades y el papel de los investigadores. Poner el conocimiento, innovación y tecnología en función de generar grandes beneficios es una oportunidad que no se debe desaprovechar. Los tiempos actuales demandan el fortalecimiento de habilidades. Permitámonos descubrir un mundo nuevo, crear redes globales con esencia en lo humano. ¿Apuestas por las oportunidades de la Cuarta Revolución Industrial (4RI)?
Heat Shock Protein-90 beta Is Expressed at the Surface of Multipotential Mesenchymal Precursor Cells: Generation of a Novel Monoclonal Antibody, STRO-4, With Specificity for Mesenchymal Precursor Cells From Human and Ovine Tissues (2009)

Mesenchymal stromal cells (MSCs) and their precursor cells (MPCs) can proliferate and differentiate into multiple mesodermal and some ectodermal and endodermal tissues. Culture-expanded MSCs are currently being evaluated as a possible cell therapy to replace/repair injured or diseased tissues. While a number of mAb reagents with specificity to human MSCs, including STRO-1, STRO-3 (BLK ALP), CD71 (SH2, SH3), CD106 (VCAM-1), CD166, and CD271, have facilitated the isolation of purified populations of human MSCs from primary tissues, few if any mAb reagents have been described that can be used to isolate equivalent cells from other species. This is of particular relevance when assessing the tissue regenerative efficacy of MSCs in large immunocompetent, preclinical animal models of disease. In light of this, we sought to generate novel monoclonal antibodies (mAb) with specific reactivity against a cell surface molecule that is expressed at high levels by MSCs from different species. Using CD106 (VCAM-1)-selected ovine MSCs as an immunogen, mAb-producing hybridomas were selected for their reactivity to both human and ovine MSCs. One such hybridoma, termed STRO-4, produced an IgG mAb that reacted with <5% of human and ovine bone marrow (BM) mononuclear cells. As a single selection reagent, STRO-4 mAb was able to enrich colony-forming fibroblasts (CFU-F) in both human and ovine BM by 16- and 8-folds, respectively. Cells isolated with STRO-4 exhibited reactivity with markers commonly associated with MSCs isolated by plastic adherence including CD29, CD44, and CD166. Moreover, when placed in inductive culture conditions in vitro, STRO-4(+) MSCs exhibited multilineage differentiation potential and were capable of forming a mineralized matrix, lipid-filled adipocytes, and chondrocytes capable of forming a glycosaminoglycan-rich matrix. Biochemical analysis revealed that STRO-4 identified the beta isoform of heat shock protein-90 (Hsp90beta). In addition to identifying an antibody reagent that identifies a highly conserved epitope expressed by MSCs from different species, our study also points to a potential role for Hsp90beta in MSC biology.
The unusually mild and facile basic hydrolysis of N-nitroso-2-(methylamino)acetonitrile (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe unusually mild and facile basic hydrolysis of N-nitroso-2-(methylamino)acetonitrileShaw Kong Chang, George W. Harrington, Harry S. Veale, and Daniel SwernCite this: J. Org. Chem. 1976, 41, 23, 3752–3755Publication Date (Print):November 1, 1976Publication History Published online1 May 2002Published inissue 1 November 1976https://pubs.acs.org/doi/10.1021/jo00885a022https://doi.org/10.1021/jo00885a022research-articleACS PublicationsRequest reuse permissionsArticle Views77Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts