gebhart/patrepeval huggingface dataset:
Regional hepatic therapies: an important component in the management of colorectal cancer liver metastases. (2013)

The treatment of colorectal cancer liver metastases (CRLM) has evolved significantly in the last 15 years. Currently, complete surgical resection remains the only potentially curative option; unfortunately, approximately 80% of patients with CRLM are not candidates for complete tumor resection. For patients with unresectable CRLM the available treatment options were historically limited; however, the development of regional hepatic therapies (RHT) and improvement of systemic chemotherapeutic regimens have emerged as viable options to improve overall survival and quality of life for this group of patients. The selection, sequence and integration of interventions into a multi-modal approach is a complex and evolving discipline. In this article, the currently available RHT modalities for CRLM are presented as a guide to the options for clinical treatment decisions.
The <i>IRE</i> gene encodes a protein kinase homologue and modulates root hair growth in <i>Arabidopsis</i> (2002)

We identified an Arabidopsis mutant, incomplete root hair elongation (ire), whose root hairs are about 40% shorter than the wild type owing to the early cessation of their growth. In contrast, the hy5 mutant has root hairs about twice as long as the wild type, possibly because of delayed cessation of growth. Thus IRE and HY5 are likely to modify the duration of growth of root hairs. We cloned the IRE locus using the T-DNA tagged line. The IRE locus encodes a protein that includes a serine/threonine protein kinase domain. The primary structure of this kinase domain shows significant similarity to a group of protein kinases among various eukaryotes. In the Arabidopsis genome there are at least three genes that are closely related to IRE. The IRE transcript was detected in every organ examined. However, the IRE promoter-GUS fusion gene was strongly expressed in the elongating root hair cells, suggesting the cell-autonomous function of IRE in root hairs. GUS activity was also detected in pollen grains, which develop by tip growth, suggesting that IRE has a common role in the tip growth of plant cells.
Nonresonant multiphoton ionization of the neutrals ablated in laser microprobe mass spectrometry analysis of GaAs and Hg0.78Cd0.22Te (1987)

A second, quadrupled Nd:YAG laser system has been incorporated into a laser microprobe mass spectrometer in order to ionize the neutral species contained in the vapor plume produced by the ablation laser of this microanalytical materials analysis technique. The irradiance of this focused postablation ionization (PAI) laser beam operating at 266 nm is sufficient to ionize all the neutral species having an ionization potential less than 9.3 eV that are contained within the irradiated volume via two photon nonresonant multiphoton ionization processes. This laser ablation/laser ionization configuration of the laser microprobe technique has been applied to the microanalysis of high-purity GaAs and Hg0.78Cd0.22Te target materials. The elemental ion yields produced in the PAI microanalysis of these materials are generally larger than those produced by the laser ablation only mode of laser microprobe analysis. The elemental ion yields of the constituents in these materials have also been evaluated as a function of the delay time between the firing of the ablation and PAI lasers at several ablation laser irradiances.
Analysis of the structure and vibrational spectra of glucose and fructose (2006)

Molecular modelling using semiempirical methods AM1, PM3, PM5 and, MINDO as well as the Density Functional Theory method BLYP/DZVP respectively were used to calculate the structure and vibrational spectra of d-glucose and d-fructose in their open chain, alpha-anomer and beta-anomer monohydrate forms. The calculated data show that both molecules are not linear; ground state and the number for the point-group C is equal to 1. Generally, the results indicate that there are similarities in bond lengths and vibrational modes of both molecules. It is concluded that DFT could be used to study both the structural and vibrational spectra of glucose and fructose.
The Use of Acetyl Bromide for the Multigram Synthesis of the Anti-HIV Agent 2′,3′-Didehydro-2′,3′-Dideoxycytidine (d4C) (1990)

Abstract Treatment of uridine (1) with acetyl bromide produced bromoacetate 2 which was reduced with Zn/Cu to give the 2′,3′-unsaturated uridine (d4U; 3). Conversion of the uracil moiety of 3 to thioamide 7 with Lawesson's reagent, followed by amination and deprotection with methanolic ammonia, afforded d4C (9). This multigram scale process for the synthesis of d4C proceeded in 20% yield from uridine.
<title>Continuous presence video bridging based on H.261 standard</title> (1993)

Multi-point videoconferencing provides the full benefits of teleconference but also incurs more involved technical issues. This paper does a detailed analysis of a continuous presence video bridge using the H.261 video coding standard. We first describe the architecture and the required operations of a coded domain bridge using H.261. We then derive the bounds of the bridge delay and the required buffer size for the implementation of the bridge. The delay and the buffer occupancy of the video bridge depend on the order, complexity, and the bit- distribution of the input video sources. To investigate a typical case, we simulate the delay and the buffer occupancy of a video bridge. We also provide a heuristic method to estimate the delay in a typical case. Several techniques were discussed to minimize the bridge delay and the buffer size. Finally, we simulate an intra slice coding and show that the delay and the buffer size can be reduced significantly using this technique.
Peptide-Derivatized Shell-Cross-Linked Nanoparticles. 1. Synthesis and Characterization (2004)

The conjugation of the protein transduction domain (PTD) from the HIV-1 Tat protein to shell-cross-linked (SCK) nanoparticles is reported as a method to facilitate cell surface binding and transduction of SCK nanoparticles. Attaching increasing numbers of peptide sequences to SCK nanoparticles in a global solution-state functionalization strategy has been devised as a method for increasing the efficiency of the cell-penetrating process. The numbers of peptides per SCK were controlled through stoichiometric balance and measured experimentally by two independent methods, UV-visible spectroscopy and phenylglyoxal analysis. PTD was conjugated in (0.005, 0.01, and 0.02) molar ratios, relative to the acrylic acid residues in the shell, to the SCK nanoparticles resulting in SCK populations possessing nominally 52, 104, and 210 (41, 83, and 202 as measured by phenylglyoxal analysis) PTD peptides per particle, respectively. The methodologies for the block copolymer and nanoparticle syntheses, peptide derivatization, and characterization of peptide-functionalized SCK nanoparticles are reported and the feasibility and efficiency of intracellular internalization of the respective SCKs were quantified.
Hormone-Sensitive Lipase: Sequence, Expression, and Chromosomal Localization to 19 cent-q13.3 (1988)

Hormone-sensitive lipase, a key enzyme in fatty acid mobilization, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin. The 757-amino acid sequence predicted from a cloned rat adipocyte complementary DNA showed no homology with any other known lipase or protein. The activity-controlling phosphorylation site was localized to Ser563 in a markedly hydrophilic domain, and a lipid-binding consensus site was tentatively identified. One or several messenger RNA species (3.3, 3.5, or 3.9 kilobases) were expressed in adipose and steroidogenic tissues and heart and skeletal muscle. The human hormone-sensitive lipase gene mapped to chromosome 19 cent-q13.3.
Remote oxidation of steroids by reagents attached to ring D. Introduction of a 9(11) double bond (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRemote oxidation of steroids by reagents attached to ring D. Introduction of a 9(11) double bondRonald Breslow and Paul KalickyCite this: J. Am. Chem. Soc. 1971, 93, 14, 3540–3541Publication Date (Print):July 1, 1971Publication History Published online1 May 2002Published inissue 1 July 1971https://pubs.acs.org/doi/10.1021/ja00743a047https://doi.org/10.1021/ja00743a047research-articleACS PublicationsRequest reuse permissionsArticle Views209Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Further Exploration of Antimicrobial Ketodihydronicotinic Acid Derivatives by Multiple Parallel Syntheses (2006)

A synthetic reexamination of a series of ketodihydronicotinic acid class antibacterial agents was undertaken in an attempt to improve their therapeutic potential. A convenient new synthesis was developed involving hetero Diels-Alder chemistry producing 74 new analogs in a multiple parallel synthetic manner and these were examined in vitro for their antimicrobial potential. Several compounds demonstrated significant broad-spectrum activity against clinically derived bacterial strains but previously known 1-(2,4-difluorophenyl)-6-(4-dimethylaminophenyl)-4-pyridone-3-carboxylic acid (7) remained the most potent compound in this class. Cross-resistance with ciprofloxacin supported a commonality of mode of action. Permiabilization of Escherichia coli cells by polymyxin B significantly enhanced potency with these agents suggesting that poor cellular uptake was primarily responsible for the disappointing activity against bacteria that some of the analogs exhibited.
[T&P Train Car] (1972)

Photograph of a T&P train car in Texas. There are other cars visible behind it. Written below the image are Harlingen, Texas Mar 6 1972 Art. Reefer (with vents & fans for onions) (Harlingen & marked return to Harlingen) and R. H. Carlson.
Bovine Pericardial Patch Fibrosis Requiring Reoperation (1988)

Glutaraldehyde-fixed bovine pericardium (GFBP) has multiple uses. Its use as a vascular patch material is under investigation. A case report of severe fibrosis causing early reoperation of a GFBP patch used to repair coarctation of the aorta is presented.
Optical pulse compression based on stationary rescaled pulse propagation in a comblike profiled fiber (2006)

In this paper, optical pulse compression using a comblike profiled fiber (CPF) is theoretically and experimentally studied, in which highly nonlinear fibers and single-mode fibers are alternately concatenated. Stationary rescaled pulse (SRP), is the main focus, which is a recently discovered nonlinear stationary pulse in CPF. The fundamental characteristics of SRP are investigated, and SRP propagation is applied to the design of the CPF pulse compressor. Using the proposed design method, the specifications of the CPF can easily be controlled, such as the compression ratio per step of the CPF or the pedestal of the output pulse. Two experimental results of pulse compression using the CPF based on the proposed design method are shown: 1) pulse compression with a large compression ratio per step of the CPF and 2) low-pedestal and wideband wavelength-tunable compression. A parametric noise-amplification phenomenon occurring in a compression process for an optical pulse sequence is also numerically analyzed.
A New Material and Novel Technique for Matrix Stimulation in High-Water-Cut Oil Wells (1998)

Abstract A new process has been developed that effectively diverts acid away from zones with high water saturation into hydrocarbon zones. This process is designed to increase the success in matrix acidizing treatments. Because of the relative permeability effect, aqueous acid predominantly enters the zone with highest water saturation, resulting in stimulation of the water zones and an increase of water cut. Although foam can be used to divert acid from the "aquifer" to the damaged oil zones, nitrogen is not readily available in some areas and additional handling equipment is required. A new non- particulate, non-gaseous material has been developed to effectively divert acid away from highly water saturated zones. The material forms a highly viscous plug when it contacts water in the matrix yet degrades when mixed with oil in the matrix of the formation. This paper discusses in detail the diversion technique and laboratory results. Laboratory tests conducted in a dual-core flow apparatus showed excellent diversion from a water-rich zone to an oil-rich zone, as well as from a high-permeability formation to a low-permeability formation. P. 675
Improving the k-svd facial image compression using a linear deblocking method (2008)

The use of sparse representations in signal processing is gradually increasing in the past several years. In a previous work we proposed a new method for compressing facial images using the K-SVD algorithm, which is a novel algorithm for training overcomplete dictionaries that lead to sparse signal representations. This method was shown to be most efficient, surpassing the JPEG2000 performance significantly. In this paper we present a significant addition to our compression algorithm in the form of image deblocking. Since the encoding is done in patches, a visually disturbing artifacts of blockiness appear in the reconstructed images. We eliminate these artifacts using a linear deblocking technique, which is based on local image filters. We construct a linear filter for each relevant pixel independently, and apply these filters as post-processing. This method is limited, but nevertheless it improves the PSNR of the reconstructed images and gives visually appealing results.
One-stage dorsal inlay oral mucosa graft urethroplasty for anterior urethral stricture (2014)

This one-stage dorsal inlay approach using dorsal oral mucosal grafts is a reliable method to create a substitute urethral plate for tubularization. This approach represents a safe option for anterior urethral stricture patients especially with grossly scarred urethral plate.
Reliable contact fabrication on nanostructured Bi2Te3-based thermoelectric materials (2013)

A cost-effective and reliable Ni-Au contact on nanostructured Bi2Te3-based alloys for a solar thermoelectric generator (STEG) is reported. The use of MPS SAMs creates a strong covalent binding and more nucleation sites with even distribution for electroplating contact electrodes on nanostructured thermoelectric materials. A reliable high-performance flat-panel STEG can be obtained by using this new method.
Reuse of cDNA Microarrays Hybridized with cRNA by Stripping with RNase H (2008)

DNA microarrays are powerful tools for global analysis of gene transcript expression. However, their high cost and the need for replication have limited their use. Here, we report a new stripping technique applicable to microarrays hybridized with cRNA with RNase H that is reproducible, leaving the DNA oligonucleotide probes intact and available for adding two additional uses. A Pearson correlation was used to assess the agreement between the first-round hybridization and the second- and third-round hybridizations. Significant correlations (R2, 0.9893 and 0.975; P < 0.001) were observed among virgin arrays and stripped arrays hybridized with the same sample. Additionally, statistical class comparison analysis globally indicated that there were essentially no differences detected following three hybridizations. Dye-swapped microarrays produced similar results. However, arrays stripped with RNase H exhibited decreased efficiency of hybridization signal with increasing use. In the present study, the oligonucleotide microarrays can be used three times.
Assessment of gait irregularities in the horse: eye vs. gait analysis (2001)

The purpose of this study was to verify the sensitivity of 2 gait analysis methods in detecting subtle lameness and to compare the results to the traditional orthopaedic evaluation. Twenty-two horses were evaluated (1) subjectively by 3 different experienced clinicians and (2) objectively with synchronised ground reaction force and accelerometric gait measurements on a treadmill. The horses were assigned for each of the 3 methods independently to one of 3 groups (GR): sound, lameness front limb, lameness hindlimb. Additionally, for each horse, the affected limb (AL) and degree of lameness (DL) were defined. The accordance between the 3 assessment methods for the categorical variables was tested with a Spearman correlation analysis. The relationship between vertical ground reaction forces and dorsoventral as well as mediolateral accelerations were studied using a Pearson correlation matrix. Significant correlation was found between the clinical GR and GR based on force (r = 0.51, P < 0.05) and acceleration data (r = 0.47, P < 0.05), respectively, and between AL based on clinical and ground reaction force (r = 0.65, P < 0.05) assessment. No significant correlation was found, neither for GR between the 2 measuring methods, nor for DL between the 3 assessment methods. The Pearson correlation matrix revealed significant correlations between peak vertical forces and dorsoventral acceleration in the hindlimbs. We conclude that the measurement of kinetic parameters represents a helpful complementary tool in the assessment of subtle gait alterations. However, this information needs to be interpreted carefully and always related to the clinical observation.
Force-Shoes ZMP Measuring System for Human Walker (2008)

A novel force-shoes system for measuring the Zero Moment Point (ZMP) of human walker is introduced in this paper, which could measure the plantar distributed normal forces and friction forces during human walking. The improved ZMP calculation method developed in this paper is easy for programming. In contrast with the previous ZMP measuring methods, there are many advantages of the proposed force-shoes system, e.g., light and novel structured, low coupling, easy for programming, less affection on normal walking, suited for long-time and diverse terrains testing. Two experiments carried out on different terrains, one is on the plain and the other is on the slope, are presented in this paper and some of the results are shown and discussed.
Differential protein expression in rat trigeminal ganglia during inflammation (2001)

A proteomics approach was used to investigate global protein changes in rat sensory ganglia exposed to pro-inflammatory stimuli. Inflammation was provoked in vivo by injecting selected facial areas with Freunds Complete Adjuvant (FCA), or by stimulating freshly isolated trigeminal ganglia ex vivo with pro-inflammatory mediators (interleukin-1β, tumor necrosis factor-α, interferon-γ). Following two-dimensional gel electrophoresis, silver staining and mass spectrometry, a protein reference map and database was generated for rat trigeminal ganglia, which to our knowledge is the first to be reported. Sixty-seven out of 85 selected protein spots were successfully identified using matrix-assisted laser desorption/ionization mass spectrometry. This reference map was used to monitor changes in the ganglia proteome induced during inflammation in vivo and ex vivo. In vivo we found that FCA treatment specifically induced differential protein expression of two unidentified protein spots and, to a lower extent, of β-tubulin. Image analysis of ganglia treated ex vivo with the cocktail of cytokines indicated that some of the changes in the protein population were also observed in vivo after FCA treatment. If the cytokine stimulation was performed in the presence of acetaminophen (paracetamol), the drug seemed to reverse the effects of cytokine treatment for at least some protein spots, restoring the same protein pattern observed in control samples.
Is participation contagious? Evidence from a household vector control campaign in urban Peru (2013)

Results support a 'contagion' model of participation, highlighting the possibility that one or two participating households can tip a block towards full participation. Future campaigns can leverage these findings by making participation more visible, by addressing stigma associated with spraying, and by employing group incentives to spray.
Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q). (1989)

Interleukin-4 (IL-4) is a potent mediator of growth and differentiation of cells of several hematopoietic lineages. Interleukin-5 (IL-5) is a lineage-specific hematopoietic growth factor that stimulates the production of eosinophils and eosinophil colonies from normal human bone marrow cells. By using somatic cell hybrids and in situ chromosomal hybridization, we localized the IL-4 and IL-5 genes to human chromosome 5 at bands q23-31, a chromosomal region that is frequently deleted [del(5q)] in patients with myeloid disorders. By in situ hybridization, the IL-4 and IL-5 genes were found to be deleted in the 5q- chromosome of four patients with refractory anemia (RA) or therapy-related acute nonlymphocytic leukemia (t-ANLL), who had a del(5q). Thus a small segment of chromosome 5 contains IL-4, IL-5, IL-3, and GM-CSF as well as other genes such as CD14 and EGR1. Our findings that each of these genes was deleted in the 5q- chromosome suggest that loss of function of one or more of these genes may play an important role in the pathogenesis of hematologic disorders associated with a del(5q).
Is there a role for oral human immunoglobulin in the treatment for norovirus enteritis in immunocompromised patients? (2011)

No treatment for NVE is available. Immunocompromised patients with NVE treated with OHIG (12 cases) were retrospectively identified and matched 1:1 by age and gender with immunocompromised patients with NVE not treated with OHIG (12 controls). Chi-squared test, t-test, bivariate conditional linear regression analyses, and Kaplan-Meier curve were performed. A total of 58.3% patients were small bowel transplant (SBT) recipients. Although not statistically significant, cases compared with controls were more likely to have had induction therapy (p = 0.25, OR = 65.3), higher peak tacrolimus levels (p = 0.43, OR = 1.04), SBT (p = 0.30, OR = 65.3), prior NVE (p = 0.42, OR = 2.0), TPN support (p = 0.42 OR = 2.0), and decrease in immunosuppression (p = 0.14, OR = 5.0). Treatment with OHIG favored resolution of diarrhea (p = 0.078, OR = 65.3) and decreased stool output seven days after treatment compared with controls (mean difference 11.95 mL/kg/day, p = 0.09). OHIG did not impact total time to resolution of diarrhea (mean 12.08 vs. 11.91 days; p = 0.63), length of hospital stay (p = 0.31, OR = 1.05), or cost of hospitalization (p = 0.32, OR = 1.0). We show a potential role of OHIG treatment for NVE. Resolution of diarrhea and decreased stool output were observed at seven days; no benefit was found for length of hospital stay or hospital cost.