gebhart/patrepeval huggingface dataset:
Multi-label relevant vector machine based simultaneous fault diagnosis (2013)

To address the simultaneous fault diagnosis problem, a Multi-Label approach that makes use of Relevance vector machines (RVM), as the learning algorithm, is proposed to decrease the number of fault identification models and deal simultaneous fault diagnosis problems. The system is proved to be efficient by the simulation test on the Tennessee Eastman Process (TEP).
Understanding the Reaction (2011)

This chapter contains sections titled: Introduction Process Complexity Topics for Data Acquisition Reaction Profiles Reaction Pictures Ionic Equilibria and Reaction Selectivity Kinetics Catalyzed Processes The Rate-Determining Step Mixing in Chemical Reactors Mixing Theory Multiphase Processes Mass Transfer Theory Mass Transfer and Mixing Requirements in Multiphase Systems Concepts of Structure and Scale for Equipment Selection Conclusion References
Subtotal colectomy vs. intraoperative colonic irrigation in the management of obstructed left colon carcinoma (1998)

We believe that subtotal colectomy is the treatment of choice for obstructed left-sided colonic carcinoma. Segmental resection with intraoperative colonic irrigation is more appropriate than subtotal colectomy only in patients with carcinomas of the rectosigmoid junction or with previous anal incontinence to avoid the appearance of postoperative diarrhea.
Aromatic Fluorine Compounds. VI. Displacement of Aryl Fluorine in Diazonium Salts<sup>1,2</sup> (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAromatic Fluorine Compounds. VI. Displacement of Aryl Fluorine in Diazonium Salts1,2G. C. Finger and R. E. OesterlingCite this: J. Am. Chem. Soc. 1956, 78, 11, 2593–2596Publication Date (Print):June 1, 1956Publication History Published online1 May 2002Published inissue 1 June 1956https://pubs.acs.org/doi/10.1021/ja01592a073https://doi.org/10.1021/ja01592a073research-articleACS PublicationsRequest reuse permissionsArticle Views456Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Novel Synthesis of 1,6-Dihydro-2-methyl-6-oxo[3,4'-bipyridine]-5-carbonitrile (Milrinone) (1985)

Wilrinone (2) was prepared either by reacting ethoxymethylenemalononitrile with l-(4-pyridinyl)-2-prop~n~ne or malanonitrile with 4-ethoxy-3-(4-pyridiny1)-3buten-2-one.lone is a novel cardiotonic agent undergoing clinical investigation.It has been synthesized by the
Recent Advances in Short QT Syndrome (2018)

Short QT syndrome is a highly malignant inherited cardiac disease characterized by ventricular tachyarrhythmias leading to syncope and sudden cardiac death. It is responsible of lethal episodes in young people, mainly infants. International guidelines establish diagnostic criteria with the presence of a QTc ≤ 340 ms in the electrocardiogram despite clinical diagnostic values remain controversial. In last years, clinical diagnosis, risk stratification as well as preventive therapies have been improved due to identification of pathophysiological mechanisms. The only effective option is implantation of a defibrillator despite Quinidine may be at times an effective option. Currently, a limited number of rare variants have been identified in seven genes, which account for nearly 20-30% of families. However, some of these variants are associated with phenotypes showing a shorter QT interval but no conclusive diagnosis of Short QT syndrome. Therefore, an exhaustive interpretation of each variant and a close genotype-phenotype correlation is necessary before clinical translation. Here, we review the main clinical and genetic hallmarks of this rare entity.
Purification and Characterization of qTBP42, a New Single-stranded and Quadruplex Telomeric DNA-binding Protein from Rat Hepatocytes (1997)

Telomeres of vertebrate chromosomes terminate with a short 5'-d(TTAGGG)-3' single-stranded overhang that can form in vitro tetrahelical structures. Here we describe a new protein from rat hepatocyte nuclei designated quadruplex telomere-binding protein 42 (qTBP42) that tightly binds 5'-d(TTAGGG)n-3' and 5'-d(CCCTAA)n-3' single-stranded and tetraplex forms of 5'd(TTAGGG)n-3'. The thermostable qTBP42 was isolated from boiled nuclear extracts and purified to near homogeneity by successive steps of column chromatography on DEAE-cellulose, phosphocellulose, and phenyl-Sepharose. A subunit molecular size of 42.0 +/- 2.0 kDa was determined for qTBP42 by Southwestern blotting and SDS-polyacrylamide gel electrophoresis of the protein and its UV cross-linked complex with labeled telomeric DNA. A native size of 53. 5 +/- 0.9 kDa, estimated by Superdex copyright 200 gel filtration, suggests that qTBP42 is a monomeric protein. Sequences of five tryptic peptides of qTBP42 contained motifs shared by a mammalian CArG box-binding protein, hnRNP A/B, hnRNP C, and a human single-stranded telomeric DNA-binding protein. Complexes of qTBP42 with each complementary strand of telomeric DNA and with quadruplex forms of the guanine-rich strand had 3.7-14.6 nM dissociation constants, Kd, whereas complexes with double-stranded telomeric DNA had up to 100-fold higher Kd values. By associating with tetraplex and single-stranded telomeric DNA, qTBP42 increased their heat stability and resistance to digestion by micrococcal nuclease.
Music-driven motion editing (2002)

Sounds are generally associated with motion events in the real world, and as a result there is an intimate connection between the two. Hence, producing effective animations requires the correct association of sound and motion, which remains an essential, yet difficult, task. But unlike prior, application-specific systems such as [Lytle90; Singer97], we address this problem with a general framework for synchronizing motion curves to perceptual cues extracted from the music. The user is able to modify existing motions rather than needing to incorporate unadapted musical motions into animations. An additional fundamental feature of our system is the use of music analysis techniques on complementary MIDI and analog audio representations of the same soundtrack.
CM55: special prime-field elliptic curves almost optimizing den Boer's reduction between Diffie-Hellman and discrete logs. (2014)

Using the Pohlig–Hellman algorithm, den Boer reduced the discrete logarithm prob-lem to the Diffie–Hellman problem in groups of an order whose prime factors were each one plus a smooth number. This report reviews some related general conjectural lower bounds on the Diffie–Hellman problem in elliptic curve groups that relax the smoothness condition into a more commonly true condition. This report focuses on some elliptic curve parameters defined over a prime field size of size 9 + 55 × 2288, whose special form may provide some efficiency advantages over random fields of similar sizes. The curve has a point of Proth prime order 1 + 55×2286, which helps to nearly optimize the den Boer reduction. This curve is constructed using the CM method. It has cofactor 4, trace 6, and fundamental discriminant −55. This report also tries to consolidate the variety of ways of deciding between elliptic
Characteristic features of human catalytic light chain, 22F6, showing the suppression of influenza virus infection by the different way (2012)

We found unique human catalytic light chains in which #4 clone showed a substantial effect on the suppression of infectivity of influenza virus A type (H1N1). Interestingly, 22F6 clone also showed a unique characteristic to prevent from the infection of influenza virus by the quite different way. Generally, in vitro assay, the virus and the antibody was first mixed and then the solution was incubated for one hour with MDCK cells in medium. Then, the plaques were counted for estimating the infection efficacy. In this study, we employed a new method in which only antibody was incubated with MDCK cells for one hour. After that, the medium solution containing the antibody was discarded and the well was washed out with the medium. Then the influenza virus dissolved in the medium without an antibody was put into the wells, followed by counting the number of plaques. C179 monoclonal antibody has been used in world widely as a famous neutralizing mAb against influenza virus H1N1 and H2N2 types. For the general in vitro assay, the mAb could completely suppress the infection of the virus against MDCK cells as expected but not in our new method. #4 clone showed the similar result. Surprisingly, 22F6 clone could lower the infectivity of the virus in our method. Namely, the functional mechanism of 22F6 clone is quite different from the neutralizing activity of C179 mAb and the catalytic activity of #4 clone.
<i>BCL2</i>-938C>A polymorphism and disease progression in chronic lymphocytic leukemia (2009)

A number of single nucleotide polymorphisms (SNP) have been implicated to impact upon the disease course of chronic lymphocytic leukemia (CLL). However, few of these association studies could be confirmed in independent studies in the past. Recently, three independent studies did not confirm the prognostic impact of a new functional SNP in the BCL2 gene (-938C>A) described by Nückel et al. For this reason we genotyped an independent group of patients with CLL (n = 271) with mature follow up and detailed analysis of molecular genetics. The genotype distribution of this BCL2 polymorphism did not differ from that described in the original work. However, genotypes were not associated with time to first treatment (TFT) and overall survival (OS) in univariate or multivariate analysis in the current cohort. Comparing the characteristics of the two study cohorts in more detail we found differences between the two cohorts demonstrating a potentially more aggressive second study cohort. However, TFT and OS in patients with CLL according to Binet A did not differ significantly depending on the genotype. Our findings underscore the need for optimally matched patient cohorts in replication studies. The study re-emphasizes the need for large cohorts and validation in independent data sets before firm conclusions can be made about genotype-phenotype associations.
Some Unusual but Instructive Surgical Emergencies (1950)

If the cause of acute symptoms is clear, proper treatment is begun without delay, including, if necessary, a well-placed incision. Only too often, however, the diagnosis is in doubt even in common conditions ; and in uncommon ones the delays and difficulties are obviously increased. The delays which occur are shown by the following eight cases, only two of which were admitted to hospital within twelve hours of the onset of the symptoms, two being delayed for two days, two for three days, one for seven days, and one for ten days. The difficulties in diagnosis are seen in the case reports which follow, and in the litera ture : for instance, in strangulation of the stomach in a diaphragmatic hernia operation is commonly delayed until gangrene has occurred (Warren, 1919), in biliary peritonitis a wrong diagnosis is usual (Fifield, 1926), and in strangula tion of gut through a hole in the greater omentum a correct diagnosis has not been reported. The following histories, with a brief discussion of the literature, are therefore presented in the hope that they may help in the diagnosis and treatment of future cases.
Broad phonetic class recognition in a Hidden Markov model framework using extended Baum-Welch transformations (2007)

In many pattern recognition tasks, given some input data and a model, a probabilistic likelihood score is often computed to measure how well the model describes the data. Extended Baum-Welch (EBW) transformations are most commonly used as a discriminative technique for estimating parameters of Gaussian mixtures, though recently they have been used to derive a gradient steepness measurement to evaluate the quality of the model to match the distribution of the data. In this paper, we explore applying the EBW gradient steepness metric in the context of Hidden Markov Models (HMMs) for recognition of broad phonetic classes and present a detailed analysis and results on the use of this gradient metric on the TIMIT corpus. We find that our gradient metric is able to outperform the baseline likelihood method, and offers improvements in noisy conditions.
A multi-criteria decision making approach for personalization itineraries in intelligent transport systems (2013)

Personalization has an important role in information systems. It is an effective solution for reducing complexity when searching information. In this way, the user feels like the system was developed for him/her. In this context, personalization can be seen as an optimization problem. To this end, we propose a multi-criteria decision making approach to personalize system. The proposed approach has been validated by applying it to personalize a system in intelligent transport field.
PTCH1+/− Dermal Fibroblasts Isolated from Healthy Skin of Gorlin Syndrome Patients Exhibit Features of Carcinoma Associated Fibroblasts (2009)

Gorlin's or nevoid basal cell carcinoma syndrome (NBCCS) causes predisposition to basal cell carcinoma (BCC), the commonest cancer in adult human. Mutations in the tumor suppressor gene PTCH1 are responsible for this autosomal dominant syndrome. In NBCCS patients, as in the general population, ultraviolet exposure is a major risk factor for BCC development. However these patients also develop BCCs in sun-protected areas of the skin, suggesting the existence of other mechanisms for BCC predisposition in NBCCS patients. As increasing evidence supports the idea that the stroma influences carcinoma development, we hypothesized that NBCCS fibroblasts could facilitate BCC occurence of the patients. WT (n = 3) and NBCCS fibroblasts bearing either nonsense (n = 3) or missense (n = 3) PTCH1 mutations were cultured in dermal equivalents made of a collagen matrix and their transcriptomes were compared by whole genome microarray analyses. Strikingly, NBCCS fibroblasts over-expressed mRNAs encoding pro-tumoral factors such as Matrix Metalloproteinases 1 and 3 and tenascin C. They also over-expressed mRNA of pro-proliferative diffusible factors such as fibroblast growth factor 7 and the stromal cell-derived factor 1 alpha, known for its expression in carcinoma associated fibroblasts. These data indicate that the PTCH1(+/-) genotype of healthy NBCCS fibroblasts results in phenotypic traits highly reminiscent of those of BCC associated fibroblasts, a clue to the yet mysterious proneness to non photo-exposed BCCs in NBCCS patients.
Prolonged partial liquid ventilation in spontaneously breathing awake animals (1999)

Percutaneously assisted intratracheal cannulation with catheter exteriorization permits prolonged PLV in spontaneously breathing, unsedated animals. Continuous perfluorocarbon exposure with this method is reproducible, consistent, and well tolerated for 24 hrs in uninjured animals.
Stable and selective guanidinium and imidazolium complexes of a macrocyclic receptor molecule (1979)

The hexacarboxylate [27]-O9 macrocyclic polyether (1) is a suitable receptor molecule forming stable and selective inclusion complexes with guanidinium and imidazolium as well as ammonium salts in aqueous solution.
VCIP135 acts as a deubiquitinating enzyme during p97–p47-mediated reassembly of mitotic Golgi fragments (2004)

The AAA-ATPase p97/Cdc48 functions in different cellular pathways using distinct sets of adapters and other cofactors. Together with its adaptor Ufd1-Npl4, it extracts ubiquitylated substrates from the membrane for subsequent delivery to the proteasome during ER-associated degradation. Together with its adaptor p47, on the other hand, it regulates several membrane fusion events, including reassembly of Golgi cisternae after mitosis. The finding of a ubiquitin-binding domain in p47 raises the question as to whether the ubiquitin-proteasome system is also involved in membrane fusion events. Here, we show that p97-p47-mediated reassembly of Golgi cisternae requires ubiquitin, but is not dependent on proteasome-mediated proteolysis. Instead, it requires the deubiquitinating activity of one of its cofactors, VCIP135, which reverses a ubiquitylation event that occurs during mitotic disassembly. Together, these data reveal a cycle of ubiquitylation and deubiquitination that regulates Golgi membrane dynamics during mitosis. Furthermore, they represent the first evidence for a proteasome-independent function of p97/Cdc48.
<i>F</i>-Propene-Dialkylamine Reaction Products as Fluorinating Agents (1979)

Abstract The reaction products of F-propene and dialkylamines, mixtures of α,α-difluoroalkylamine and α-fluoro enamine, were found to be useful fluorinating agents for alcohols and carboxylic acids. These reagents were superior to the adduct of chlorotrifluoroethene and diethylamine, the so-called Yarovenko reagent, for their readier preparation and higher stability.
Nucleic Acid Sequence-Based Amplification Assay for Human Papillomavirus mRNA Detection and Typing: Evidence for DNA Amplification (2010)

Human papillomavirus (HPV) E6/E7 mRNA has been proposed as a more specific marker for cervical dysplasia and cancer than HPV DNA. This study evaluated the RNA specificity of nucleic acid sequence-based amplification (NASBA)-based HPV detection using HPV DNA plasmids (HPV type 16 [HPV16], HPV18, HPV31, HPV33, and HPV45) and nucleic acid extracts of several cell lines, which were systematically subjected to enzymatic treatments with DNase and RNase. HPV plasmid dilutions (10(6) to 10(0) copies/microl) and nucleic acid extracts (total DNA, RNA-free DNA, total RNA, and DNA-free RNA) of unfixed and fixed (PreServCyt and SurePath) HaCaT, HeLa, and CaSki cells were tested with the NucliSENS EasyQ HPV test. The RNA-free DNA extracts of HeLa and CaSki cells could be amplified by HPV18 and -16 NASBA, respectively. Fixation of the cells did not influence NASBA. All HPV plasmids could be detected with NASBA. Based on the plasmid dilution series, a lower detection limit of 5 x 10(3) HPV DNA copies could be determined. Our study identified viral double-stranded DNA as a possible target for NASBA-based HPV detection. The differences in diagnostic accuracy between the NASBA-based tests and conventional HPV DNA detection assays seem to be attributable not to the more specific amplification of viral mRNA but to the limited type range and the lower analytical sensitivity for HPV DNA.
Development of a New Gravity Separator for Plastics &mdash;a Hybrid-Jig&mdash; (2009)

The development of mechanical methods for plastic-plastic separation is important for recycling of scrapped plastics of office/home appliances and cars. This paper proposes a Hybrid-Jig as a new method for plastic-plastic separation. The Hybrid-Jig was developed based on jigging and flotation, where air bubbles are introduced into the particle bed during jigging to modify the apparent specific gravity of the particles by the attachment of air bubbles to the particles so that particles having different surface properties can be separated by jigging even if their specific gravities are similar.To demonstrate the performance of the Hybrid-Jig, a laboratory scale TACUB jig was modified to induce air bubbles through the screen under the particle bed, and separation experiments of plastic particle mixtures were carried out under various displacements and frequencies of water pulsation. Feed samples were particle mixtures of two plastics chosen from eight kinds of plastics (3 of polyvinyl chloride (PVC), 4 of polyethylene (PE), and 1 of polyethylene terephthalate (PET)). The particles were cylindrical of 2–3 mm length and diameter, and their specific gravities were 1.05–1.55.In normal jig operation (without air bubbles), plastic particles with similar specific gravities were difficult to separate, but they were easily separated by the Hybrid-Jig, when air bubbles adsorbed on the surface of the more hydrophobic plastics, and the plastic particles with air bubbles were recovered as top product due to the decrease in apparent specific gravity. Because the differences in the hydrophobicity of the plastics cause the selective bubble attachment, high grade plastic products over 99.9 mass% were recovered by the Hybrid-Jig even for plastic mixtures having the same specific gravity.
Type ii collagen‐induced arthritis. A Morphologic and Biochemical Study of Articular Cartilage (1983)

Articular cartilage was obtained from type II collagen-induced arthritic rat joints. Transmission electron microscopy showed a gradual degeneration of chondrocytes, disorganization of the collagenous extracellular matrix, and formation of microscars. Biochemical analyses indicated that type II collagen was the only collagen present and that it was normal in regard to hydroxylation of lysine and glycosylation of hydroxylysine. Analyses of the proteoglycan in the extracellular matrix revealed a 50% loss of chondroitin sulfate and keratan sulfate.
[Characteristics of a cell line obtained from a human hypernephroma]. (1985)

A stable tumorigenic cell line has been obtained from the human hypernephrome. The culture grew as monolayers of large polygonal cells with foamy cytoplasm and 1-2 nucleoli. The cells formed monolayer after the third day after planting into flask and then formed multilayered growth. The electron microscopic studies of hypernephrome sections revealed the dark and light cells. The hypernephrome cells have characteristics of tumor cells. On the 200th passage the cells are aneuploid with a model number of 62 chromosomes; an acrocentric chromosome in D group is noted as a marker one. The hypernephrome cells are free of Mycoplasma contamination, able to support the several virus replication.
Optimizing Apparent Display Resolution Enhancement for Arbitrary Videos (2013)

Display resolution is frequently exceeded by available image resolution. Recently, apparent display resolution enhancement (ADRE) techniques show how characteristics of the human visual system can be exploited to provide super-resolution on high refresh rate displays. In this paper, we address the problem of generalizing the ADRE technique to conventional videos of arbitrary content. We propose an optimization-based approach to continuously translate the video frames in such a way that the added motion enables apparent resolution enhancement for the salient image region. The optimization considers the optimal velocity, smoothness, and similarity to compute an appropriate trajectory. In addition, we provide an intuitive user interface that allows to guide the algorithm interactively and preserves important compositions within the video. We present a user study evaluating apparent rendering quality and show versatility of our method on a variety of general test scenes.