gebhart/patrepeval huggingface dataset:
Bioelectrical impedance can predict skeletal muscle and fat-free skeletal muscle of beef cow primal cuts (1994)

Multiple linear regression equations predicting total skeletal muscle (TM) and total skeletal fat-free muscle (TFFM) of chuck, rib, loin, and round were developed from data of 33 beef cows. Primal cuts were obtained in accordance with NAMP specifications. A four-terminal impedance meter/plethysmograph measured resistance and reactance on each cut using 20- and 13-gauge needles as electrodes. Weight, internal temperature, and distance between detector electrodes were recorded. Each cut was physically separated into muscle, fat, and bone. Chemical composition (moisture, protein, and fat) was obtained on the muscle portion of each cut so that TFFM could be obtained by multiplying TM x 1 minus the percentage of fat from the proximate analysis. The predictor variables for all combinations of cuts and electrode sizes were weight, distance between detector electrodes, temperature, and resistance, except for the round for which reactance was a fifth predictor. The P value for the resistance coefficient was < .001 for all 16 prediction equations. Adjusted R2 values of the prediction equations ranged from an average of .91 for the rib to an average of .96 for the round. Mallows Cp values were close to the ideal value of the number of independent variables in the prediction equations plus one (1). Prediction equations for the different size electrodes were similar.(ABSTRACT TRUNCATED AT 250 WORDS)
Radioimmunotherapy for breast cancer using indium-111/yttrium-90 BrE-3: results of a phase I clinical trial. (1997)

Minimal toxicity, dosimetric calculations and clinical assessment indicate that a useful therapeutic index can be achieved with this therapy. Indium-111/yttrium-90-MX-DTPA BrE-3 can be safely administered to patients with metastatic breast cancer, and therapy doses yielded pharmacokinetics similar to those of tracer doses. Clinical responses, albeit transient, were achieved with single-dose therapy. Rapid onset of the HAMA response will hinder multicycle therapy, unless it is prevented with immunosuppressive drugs or the use of a "humanized" antibody. Further studies are needed to determine the optimal use of BrE-3 for radioimmunotherapy.
Adsorptive separation of propylene-propane mixtures (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdsorptive separation of propylene-propane mixturesHarri Jarvelin and James R. FairCite this: Ind. Eng. Chem. Res. 1993, 32, 10, 2201–2207Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/ie00022a001https://doi.org/10.1021/ie00022a001research-articleACS PublicationsRequest reuse permissionsArticle Views3308Altmetric-Citations154LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sistema de Codificação de Voz de Alta Qualidade com Banco de Filtros (2013)

This paper describes a high quality speech coding&nbsp;system based in the ITU Recommendation G.722 &ldquo;7 kHz&nbsp;audio coding within 64 kbit/s&rdquo;. Provides a high-level&nbsp;description of the recommended algorithm and a brief&nbsp;discussion about the arithmetical choices, which have been&nbsp;made. Some performance results are provided.
4,4',4''-Tris(benzoyloxy)trityl as a new type of base-labile group for protection of primary hydroxyl groups (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT4,4',4''-Tris(benzoyloxy)trityl as a new type of base-labile group for protection of primary hydroxyl groupsMitsuo Sekine and Tsujiaki HataCite this: J. Org. Chem. 1983, 48, 18, 3011–3014Publication Date (Print):September 1, 1983Publication History Published online1 May 2002Published inissue 1 September 1983https://pubs.acs.org/doi/10.1021/jo00166a014https://doi.org/10.1021/jo00166a014research-articleACS PublicationsRequest reuse permissionsArticle Views338Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Classification of HIV-1 Protease Inhibitors by Machine Learning Methods (2018)

HIV-1 protease plays an important role in the processing of virus infection. Protease is an effective therapeutic target for the treatment of HIV-1. Our data set is based on a selection of 4855 HIV-1 protease inhibitors (PIs) from ChEMBL. A series of 15 classification models for predicting the active inhibitors were built by machine learning methods, including <i>k</i>-nearest neighors (K-NN), decision tree (DT), random forest (RF), support vector machine (SVM), and deep neural network (DNN). The molecular structures were characterized by (1) fingerprint descriptors including MACCS fingerprints and PubChem fingerprints and (2) physicochemical descriptors calculated by CORINA Symphony. The prediction accuracies of all of the models are more than 70% on the test set; the best accuracy of 83.07% was obtained by model 4A, which was built by the SVM method based on MACCS fingerprint descriptors. Nine consensus models were built with three kinds of different descriptors, which combined all of the machine learning methods using the "consensus prediction". Model C3<sub>a</sub> developed with MACCS fingerprint descriptors showed the highest accuracy on both training set (91.96%) and test set (83.15%). An external validation set including 35 989 compounds from DUD database and 239 active inhibitors from the recent literature was used to verify the performance of our model. The best prediction accuracy of 98.37% was obtained by model 3C, which was built by RF based on CORINA Symphony descriptors. In addition, from the analysis of molecular descriptors, it shows that the aromatic system and atoms related to hydrogen bonding provide important contributions to the bioactivity of PIs.
Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages (1999)

The recognition of mycobacterial cell wall components causes macrophages to secrete tumor necrosis factor alpha (TNF-alpha) and other cytokines that are essential for the development of a protective inflammatory response. We show that toll-like receptors are required for the induction of TNF-alpha in macrophages by Mycobacterium tuberculosis. Expression of a dominant negative form of MyD88 (a signaling component required for toll-like receptor signaling) in a mouse macrophage cell line blocks TNF-alpha production induced by M. tuberculosis. We identify toll-like receptor-2 (TLR2) as the specific toll-like receptor required for this induction by showing that expression of an inhibitory TLR2 (TLR2-P681H) blocks TNF-alpha production induced by whole M. tuberculosis. Further, we show that TLR2-dependent signaling mediates responses to mycobacterial cell wall fractions enriched for lipoarrabinomannan, mycolylarabinogalactan-peptidoglycan complex, or M. tuberculosis total lipids. Thus, although many mycobacterial cell wall fractions are identified to be inflammatory, all require TLR2 for induction of TNF-alpha in macrophages. These data suggest that TLR2 is essential for the induction of a protective immune response to mycobacteria.
Effect of non-spherical bearing geometry on transient elastohydrodynamic lubrication in metal-on-metal hip joint implants (2007)

Abstract A transient elastohydrodynamic lubrication model for non-spherical bearing surfaces of artificial hip joint implants under walking conditions has been developed. A nominal ball-in-socket configuration was employed to represent the articulation between a spherical femoral head and a non-spherical acetabular cup in this study. The non-sphericity of the bearing geometry was described by an ellipsoid with the variation of three ellipsoidal semi-axis lengths relative to the nominal spherical surface. An appropriate spherical coordinate system and mesh grids were selected to facilitate the numerical simulation. Both the equivalent discrete spherical convolution model and the corresponding spherical fast Fourier transform technique were used to evaluate the elastic deformation of both the spherical head and non-spherical cup surfaces. The transient lubrication model was subsequently adopted to investigate the effect of nonsphericity of an ellipsoidal cup on the transient elastohydrodynamic lubrication in a typical metal-on-metal hip joint implant. It was found that the non-sphericity could have a large effect on the predicted film thickness and the maximum pressure by as much as ∼43 and 17 per cent respectively, for the conditions considered in this study, depending on the orientation of the non-spherical cup relative to the flexion-extension direction. Furthermore, the non-sphericity of the cup bearing surface, which can be caused by shape tolerance in manufacturing or wear in clinical application, was discussed, in relation to the lubrication.
Intake and Efficacy of Methoprene and Stirofos Mineral Blocks for Control of Horn Flies (Diptera: Muscidae) on Pastured Beef Cattle (1993)

Pastured herds of Shorthorn beef cattle, Bos taurus L., in western Minnesota were treated with different insecticidal mineral blocks during the summers of 1990 and 1991. Treatments were noninsecticidal blocks (MoorMan’s 646-B Special Range Mineral Block A), 0.02% methoprene blocks (MoorMan’s 650-B), and 0.5% stirofos blocks (Sweetlix). Mineral intake was monitored once or twice per wk. To evaluate efficacy, identified animals from the three herds were commingled for 18 h in one pasture to allow naturally occurring horn flies, Haematobia irritans irritans (L.), to oviposit in the animals’ dung pats. Just before adults emerged, horn fly puparia were extracted to assess the effects of the insecticidal minerals on the developing flies. Intake of all three blocks varied substantially among weeks but most often exceeded prescribed rates. Methoprene blocks consistently increased pupal mortality, but offsetting increases in pupal densities negated effectiveness. Stirofos blocks did not increase larval mortality. Neither insecticidal block effectively prevented within-pasture production of horn flies under field conditions.
High‐strength–high‐modulus polyimide fibers II. Spinning and properties of fibers (1986)

Abstract The polyimides based on 3,3′,4,4′‐biphenyltetracarboxylic dianhydride (BPDA) described in Part I of this series were dissolved in p ‐chlorophenol and spun into fibers using a coagulating bath of ethanol. The fibers as spun had in general low tenacities and low moduli, but a heat treatment at 300–500°C under tension produced a remarkable increase in strength and modulus, and fibers with a tensile strength of 26 g/den (3.1 GPa) and an initial modulus higher than 1,000 g/den (120 GPa) could be obtained. Thus, the annealed fibers of polyimides are comparable to aramid fibers in mechanical properties. To heating in air and in the saturated steam, the polyimide fibers showed higher resistance than the aramid fibers. The polyimide fibers surpassed the aramid fibers in resistance to acid treatment and ultraviolet (UV) irradiation, but were inferior in resistance to alkali treatment. The annealed fibers of polyimides displayed distinct X‐ray diffraction patterns. The chain repeat distance of 20.5 Å determined on the fibers of polyimide prepared from BPDA and o ‐tolidine, and 20.6 Å determined on the fibers of polyimide derived from BPDA and 3,4′‐diaminodiphenyl ether are reasonable when the dimensions of monomeric units and the shapes of the molecular chains are considered. The X‐ray reflections of both polyimide fibers were indexed satisfactorily on the basis of postulated unit cells.
Improving BHA Tool Reliability with Drillstring Vibration Models: Field Experience and Limitations (1987)

ABSTRACT Statistics on BHA tool components revealed significantly more failures in vertical holes than in deviated holes. The difference was attributed to damping of vibrations at stabilizers in deviated holes. Modelling of drillstring vibrations showed that high shocks associated with transverse vibrations of the BHA were the probable cause of failure. A model of the transverse vibration response of the BHA was developed to improve the design and the location of the tools in the drillstring. The model was able to associate the failure of many MWD and other components with resonance in the drillstring. Application of the model at the BHA planning stage reduced the number of tool failure attributed to BHA design and operating conditions by about one half. As a consequence a rig site program was developed. This paper gives examples of field case studies, describes the rig site model, and discusses the sometimes real limitations of BHA vibration models.
Adaptive Learning Environments and e-Learning Standards. (2004)

This paper examines the sufficiency of existing eLearning standards for facilitating and supporting the introduction of adaptive techniques in computer-based learning systems. To that end, the main representational and operational requirements of adaptive learning environments are examined and contrasted against current eLearning standards. The motivation behind this preliminary analysis is attainment of: interoperability between adaptive learning systems; reuse of adaptive learning materials; and, the facilitation of adaptively supported, distributed learning activities.
Cytogenetic abnormalities of cotton somaclones from callus cultures (1989)

Somaclonal variation occurs among regenerants from tissue culture of many plant species. Our objective was to determine whether cytogenetic variation contributes to somaclonal variation in cotton (Gossyptum hirsutum L.,2n = 4x = 52). Of 117 somaclones of cotton regenerated from 18-month-old callus cultures of 'SJ-2' and 'SJ-5' cultivars, 35 were analyzed for meiotic abnormalities. The population of somaclones was extremely varied in phenotype, most plants being strikingly aberrant in phenotype. Fertility was generally poor: 84% failed to set bolls and only 5% set 10 or more bolls in a field environment. Only one of the somaclones (3%) formed 26 bivalents at metaphase I. Fourteen were nonsynaptic to partially synaptic at metaphase I. Synaptic abnormalities impaired fertility and precluded thorough metaphase analysis. Chromosome numbers obtained for 32 plants ranged from 49 to 53, and only 1 plant was hyperaneuploid. No plant was polyploid. Chromosomal abnormalities in plants with normal metaphase pairing included univalents, unequal bivalents, rod bivalents, trivalents, open quadrivalents, and centric fragments. Seventeen hypoaneuploid plants formed a V-shaped trivalent at metaphase I, constituting a high frequency of tertiary monosomy. The high frequencies of aneuploidy and tertiary monosomy indicate that cytogenetic anomalies are a major source of somaclonal variation in cotton. It is hypothesized that (i) primary cytogenetic events during cotton cell culture give rise to breakage – fusion – bridge (BFB) cycles, (ii) BFB cycles accrue during culture, (iii) BFB cycles cause loss of chromatin, and (iv) BFB cycles are resolved by the formation of stable tertiary chromosomes with mono-centric activity. The hypothesis accounts mechanistically for the coincidence of chromatin deficiencies and chromatin exchange involved implicitly in tertiary monosomy, as well as for the relatively high frequency of tertiary monosomy among somaclones.Key words: aneuploid, monosomic, synaptic, sterility, Gossypium.
Measurement Of Multilayer Mirror Reflectivity And Stimulated Emission In The XUV Spectral Region (1985)

In recent years there has been a great deal of work aimed at generating soft x-ray lasing action in the laboratiory, and a number of promising schemes to demonstrate this have been discussed at length'. Recently, there have been several encouraging experimental demonstrations of significant amplification of soft x-rays. The achieved gain length products have been as high as 6.0-6.5 in these experiments.2,3
Ordered CSMA: a collision-free MAC protocol for underwater acoustic networks (2007)

Since underwater acoustic (UWA) networks have the nature of long propagation delay, low bit rates and error-prone acoustic communication, protocols designed for underwater acoustic networks are significantly different from that of terrestrial radio networks. Limited by these nature of UWA channels, conventional medium access control (MAC) protocols of radio packet network ether have low efficiency or are not able to apply to underwater acoustic networks. It is necessary to develop an efficient MAC protocol for underwater acoustic networks. In this paper, a collision-free MAC protocol for UWA networks called Ordered Carrier Sense Multiple Access (Ordered CSMA) is proposed and analyzed. Ordered CSMA combines the concepts of round-robin scheduling and CSMA. In Ordered CSMA, each station transmits data frame in a fixed order. More specifically, each station transmits immediately after the data frame transmission of last station in the order, instead of waiting for a period of maximum propagation delay. To achieve this, each station is constantly sensing the carrier and listens to all received frames. Due to the characteristics of collision free and high channel utilization, Ordered CSMA shows a great MAC efficiency improvement in our simulations, compared to previous works.
Naltrexone and Disulfiram in Patients With Alcohol Dependence and Current Depression (2007)

The results suggest that disulfiram and naltrexone are safe pharmacotherapeutic agents for dually diagnosed individuals with depression for the treatment of alcohol use disorders.
Processing of the plum pox virus polyprotein at the P3-6K1 junction is not required for virus viability (1995)

Proteolytic processing of the potyvirus polyprotein is mainly performed by the virus-encoded NIa protease, whose cleavage sites are characterized by conserved heptapeptide sequences. Partial processing at the cleavage site present between the P3 and 6K1 cistrons by the plum pox potyvirus (PPV) NIa protease has been previously shown to occur in vitro. We have now studied the role of polyprotein processing at the P3-6K1 junction in vivo, using a full-length PPV cDNA clone. PPV mutant transcripts containing a histidine for glutamine substitution in the cleavage site sequence (a change that abolishes in vitro processability) are able to infect Nicotiana clevelandii plants, indicating that normal processing at the P3-6K1 junction is not required for virus viability. However, disease symptoms were not detected and virus accumulation occurred after a second site mutation was introduced into the 6K1 cistron during replication. This additional change did not restore the in vitro processability of the mutant heptapeptide. Changes at other positions in the heptapeptide (that only slightly altered the in vitro processability of this NIa site) were also engineered and it was found that these mutations affected the time course and severity of the symptom induction process. A possible regulatory effect on the function of the potyvirus P3 + 6K1 protein by processing at the P3-6K1 junction is discussed in light of our present results with PPV.
Suggested mechanism for the production of malonaldehyde during the autoxidation of polyunsaturated fatty acids. Nonenzymic production of prostaglandin endoperoxides during autoxidation (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuggested mechanism for the production of malonaldehyde during the autoxidation of polyunsaturated fatty acids. Nonenzymic production of prostaglandin endoperoxides during autoxidationWilliam A. Pryor and J. P. StanleyCite this: J. Org. Chem. 1975, 40, 24, 3615–3617Publication Date (Print):November 1, 1975Publication History Published online1 May 2002Published inissue 1 November 1975https://pubs.acs.org/doi/10.1021/jo00912a038https://doi.org/10.1021/jo00912a038research-articleACS PublicationsRequest reuse permissionsArticle Views1132Altmetric-Citations321LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts