gebhart/patrepeval huggingface dataset:
Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization (1998)

To investigate the possible consequences of uterine contractions (UC) as visualized by ultrasound (US) on in-vitro fertilization (IVF)-embryo transfer outcome, we studied prospectively 209 infertile women undergoing 220 cycles of controlled ovarian stimulation. Inclusion criteria were age < or = 38 years, a morphologically normal uterus, and at least three good quality embryos transferred. Just before embryo transfer, women underwent 5 min digital recordings of the uterus using US image analysis software for UC assessment. Plasma progesterone and oestradiol concentrations were measured. Four groups were defined according to UC frequency: < or = 3.0 (n = 53), 3.1-4.0 (n = 50), 4.1-5.0 (n = 43), and > 5.0 (n = 74) UC/min respectively. Patients, controlled ovarian hyperstimulation and embryology characteristics were comparable in all groups. A stepwise decrease in clinical and ongoing pregnancy rates as well as in implantation rates occurred from the lowest to the highest UC frequency groups (53, 36, 21; 46, 32, 20; 23, 19, 10; and 14, 11, 4%; P < 0.001). Plasma progesterone and UC frequency were negatively correlated (r = -0.34, P < 0.001). Direction of UC did not affect embryo transfer outcome. As this study was controlled strictly for confounding variables and UC were assessed objectively by a computerized system, its results indicate that high frequency UC on the day of embryo transfer hinder IVF-embryo transfer outcome, possibly by expelling embryos out of the uterine cavity. The negative correlation between UC frequency and progesterone concentrations supports the uterine relaxing properties of progesterone.
PSEUDO BASES IN THE ISOXAZOLE SERIES. FOURTH PAPER (1931)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPSEUDO BASES IN THE ISOXAZOLE SERIES. FOURTH PAPERE. P. Kohler and W. F. BruceCite this: J. Am. Chem. Soc. 1931, 53, 2, 644–651Publication Date (Print):February 1, 1931Publication History Published online1 May 2002Published inissue 1 February 1931https://pubs.acs.org/doi/10.1021/ja01353a030https://doi.org/10.1021/ja01353a030research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cell Adhesion Regulates Ubiquitin-mediated Degradation of the Platelet-derived Growth Factor Receptor β (2000)

Cross-talk between integrin-mediated adhesion and growth factors has been described in many recent studies; however, the underlying mechanisms remain incompletely understood. We report here that detachment of cells from the extracellular matrix induced a decrease in both the autophosphorylation and protein levels of the platelet-derived growth factor receptor beta (PDGF-R beta), which was completely reversed upon replating cells on fibronectin. The effect occurred in all cells examined but to a greater extent in primary fibroblasts compared with established cell lines. Decreased PDGF-R levels in suspended cells correlated with ubiquitination of the PDGF-R and was blocked by treatment with inhibitors of the proteasome pathway. Unlike PDGF-induced down-regulation, detachment-induced degradation did not require receptor autophosphorylation, internalization, or tyrosine kinase activity. We conclude that cell detachment results in cellular desensitization to PDGF that is mediated by degradation of the PDGF-R via a novel ubiquitin-dependent pathway.
Network management system for Quantum Key Distribution (2011)

Quantum Key Distribution (QKD) is developed to improve the security network in key exchange field. There are several success network equipment in implement QKD. However, the key distribution is limited to use in point-to-point scope. In this paper, we propose a design in quantum cryptography network that will extend the ability of number of users in present quantum cryptography network from point-to-point to multi-user network and sustain the security of the network. The developed system is implemented based on the existing quantum cryptography by managing the pairs joining of QKD system. The result of simulation is proven the feasibility to implement the proposed concept in real implementation.
Italy: Court of Rome: no need for a detailed notice to trigger ISP’s liability (2016)

In its decision filed on 27 April 2016, the Court of First Instance of Rome (Tribunale di Roma) states that even a non-detailed cease-and-desist letter (i.e., a letter without any indication of the URLs), subject to specific conditions, may be deemed sufficient to oblige the relevant hosting provider to remove the infringing content.
Coherent Exciton–Surface-Plasmon-Polariton Interaction in Hybrid Metal-Semiconductor Nanostructures (2008)

We report measurements of a coherent coupling between surface plasmon polaritons (SPP) and quantum well excitons in a hybrid metal-semiconductor nanostructure. The hybrid structure is designed to optimize the radiative exciton-SPP interaction which is probed by low-temperature, angle-resolved, far-field reflectivity spectroscopy. As a result of the coupling, a significant shift of approximately 7 meV and an increase in broadening by approximately 4 meV of the quantum well exciton resonance are observed. The experiments are corroborated by a phenomenological coupled-oscillator model predicting coupling strengths as large as 50 meV in structures with optimized detunings between the coupled exciton and SPP resonances. Such a strong interaction can, e.g., be used to enhance the luminescence yield of semiconductor quantum structures or to amplify SPP waves.
Human duodenal myoelectric activity after operation and with pacing. (1990)

We sought to determine the influence of operation on the pattern of human duodenal myoelectric activity and to assess whether electrical pacing might correct any postoperative disturbances. Three pairs of temporary bipolar serosal electrodes were placed on the duodenums of ten patients undergoing cholecystectomy. Electrical recordings were obtained daily until the patients' discharge, at 3 to 7 days, after operation. On each postoperative day, a regular rhythmic pattern of pacesetter potentials (PPs) was detected in all patients. The PP frequency (mean +/- SEM) was greater at the proximal electrode than at the distal electrode on the first postoperative day (12.3 +/- 0.1 cpm vs 11.9 +/- 0.1 cpm, p less than 0.01) and on the day of feeding (12.0 +/- 0.2 cpm vs 11.6 +/- 0.2, p less than 0.01). Spontaneous periods when spike potentials accompanied each PP (phase III of the migrating myoelectric complex), were found in only one patient on the day after operation, while they were recorded in five patients after 3 to 7 days, when postoperative ileus had resolved (p less than 0.05). Pacing with electric pulses (50 msec, 5 to 15 mA, 11 to 13 cpm) did not alter the pattern of duodenal PPs or entrain them in the duodenum of any patient at any time after operation. In conclusion, the pattern of duodenal pacesetter potentials changed little during the period of postoperative ileus, while the incidence of phase IIIs of the migrating myoelectric complex was greatly decreased.(ABSTRACT TRUNCATED AT 250 WORDS)
Field test of a navigation system: autonomous cleaning in supermarkets (2002)

Siemens has developed a prototype of an autonomous navigation system for mobile service robots. Its suitability for tough everyday operation has been successfully demonstrated since August 1996 with cleaning machines in chain store supermarkets of Albert Heijn BV in the Netherlands. Here, HEFTER CLEANTECH (HCT) cleaning robots are being used in cooperation with the cleaning specialist RTB.
Functionalization of Nanofibrillated Cellulose with Silver Nanoclusters: Fluorescence and Antibacterial Activity (2011)

Native cellulose nanofibers are functionalized using luminescent metal nanoclusters to form a novel type of functional nanocellulose/nanocluster composite. Previously, various types of cellulose fibers have been functionalized with large, non-luminescent metal nanoparticles. Here, mechanically strong native cellulose nanofibers, also called nanofibrillatedcellulose (NFC), microfibrillatedcellulose (MFC) ornanocellulose, disintegrated from macroscopic cellulose pulp fibers are used as support for small and fluorescent silver nanoclusters. The functionalization occurs in a supramolecular manner, mediated by poly(methacrylic acid) that protects nanoclusters while it allows hydrogen bonding with cellulose, leading to composites with fluorescence and antibacterial activity.
Parallel performance prediction using lost cycles analysis (1994)

Most performance debugging and tuning of parallel programs is based on the measure-modify approach, which is heavily dependent on detailed measurements of programs during execution. This approach is extremely time-consuming and does not lend itself to predicting performance under varying conditions. Analytic modeling and scalability analysis provide predictive power, but are not widely used in practice, due primarily to their emphasis on asymptotic behavior and the difficulty of developing accurate models that work for real-world programs. In this paper we describe a set of tools for performance tuning of parallel programs that bridges this gap between measurement and modeling.Our approach is based on lost cycles analysis, which involves measurement and modeling of all sources of overhead in a parallel program. We first describe a tool for measuring overheads in parallel programs that we have incorporated into the runtime environment for Fortran programs on the Kendall Square KSR1. We then describe a tool that fits these overhead measurements to analytic forms. We illustrate the use of these tools by analyzing the performance tradeoffs among parallel implementations of 2D FFT. These examples show how our tools enable programmers to develop accurate performance models of parallel applications without requiring extensive performance modeling expertise.
Tumor Necrosis Factor Enhances the Capsaicin Sensitivity of Rat Sensory Neurons (1997)

The capacity of the proinflammatory cytokines, tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta), to modulate the sensitivity of isolated sensory neurons grown in culture to the excitatory chemical agent capsaicin was examined. Alterations in capsaicin sensitivity were assessed by quantifying the number of neurons labeled with cobalt after exposure to capsaicin and by recording the whole-cell response from a single neuron to the focal application of capsaicin. A 24 hr pretreatment of the neuronal cultures with TNF alpha (10 or 50 ng/ml), but not IL-1 beta (10 or 50 ng/ml), produced a concentration-dependent increase in the number of cobalt-labeled neurons after exposure to 100 nM capsaicin. The peak increase in the number of labeled neurons was attained after a 4 hr treatment with 10 ng/ml TNF alpha. Similarly, pretreatment with TNF alpha (10 ng/ml for 4, 12, and 24 hr) produced a greater than twofold increase in the average peak amplitude of the inward current evoked by 100 nM capsaicin. Both the TNF alpha-induced increase in labeling and current amplitude were blocked by treating the neuronal cultures with indomethacin before the addition of TNF alpha. Enhancement of the capsaicin-evoked current also was blocked by the specific cyclo-oxygenase-2 inhibitor SC-236. These results indicate that TNF alpha can enhance the sensitivity of sensory neurons to the excitation produced by capsaicin and that this enhancement likely is mediated by the neuronal production of prostaglandins. Isolated sensory neurons grown in culture may prove to be a useful model system in which to explore how prolonged exposure to mediators associated with chronic inflammation alter the regulatory pathways that modulate the excitability of the nervous system.
The Importance of Endospore-Forming Bacteria Originating from Soil for Contamination of Industrial Food Processing (2011)

Specific endospore formers have become important contaminants in industrial food processing. The direct or indirect soil route of contamination or dispersal is the start of events or processes in the agrofood chain that eventually leads to important problems or concerns for food safety and/or quality. Three important food sectors are discussed in this paper. In the dairy sector, Bacillus cereus , the most important pathogen or spoilage organism in this sector, and Clostridium tyrobutyricum , the most important spoiler in certain cheeses, both contaminate pasteurized milk through the faecal and/or (at least for B. cereus ) the direct soil route. In the fruit juice industry, Alicyclobacillus acidoterrestris , present on raw fruits, has become a major quality-target organism. In the ready-to-eat food sector, B. cereus and other aerobic endospore formers are introduced via vegetables, fruits, or herbs and spices, while anaerobic spore formers like nonproteolytic Clostridium botulinum and Clostridium estertheticum pose safety and spoilage risks in chilled packaged foods, respectively.
<title>Temporal partitioning of circuits for advanced partially reconfigurable systems</title> (2001)

Reconfigurable architectures are proving to be very effective in applications that involve the implementation of multiple compute-intensive algorithms, which share the same computing modules. With the advent of dynamically reconfigurable architectures, many temporal partitioning algorithms (TPA) have been proposed address the issue of area and time constraints. The main objective of TPA is to divide a large design into smaller sub-components so that they can be implemented over multiple reconfigurations. In this paper, we propose a new temporal partitioning process (TPP), which includes a modified TPA along with a port reallocation algorithm (PRA) to reduce the reconfiguration time to facilitate real-time implementation. The reduction in reconfiguration time is achieved by employing the knowledge of the function implemented in each logic block thereby effectively reusing the cells in the array in a selective manner. This avoids the need for complete reconfiguration and reduces the net reconfiguration time. The proposed approach has been tested on random graphs and on the MCNC benchmark circuits. Significant reduction in reconfiguration time has been achieved.
Mutations located on both F1 and F2 subunits of the Newcastle disease virus fusion protein confer resistance to neutralization with monoclonal antibodies (1989)

The fusion gene sequence of six Newcastle disease virus escape mutants revealed that residues important for the integrity of antigenic site 1 and antigenic site 2 were located, respectively, on the F2 subunit and within the cysteine-rich domain of the F1 subunit. We further report the antibody-binding capacity of these mutants.
The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias. (2004)

Our data suggest that PI-9 in pediatric ALL is differentially expressed, without close correlation to subtype. Since PI-9 considerably alters GrzB and killer cell sensitivity, it may strongly influence the efficacy of GvL effects. The approaches applied here will allow evaluation of the expression and function of PI-9 in larger series of malignancies.
Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes (2004)

In the February 2004 issue of Diabetes Care , the American Diabetes Association (ADA) published a summary of their conclusions drawn from the Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes (1). Although the ADA ranked the diabetes risk for second-generation antipsychotics (SGAs), the U.S. Food and Drug Administration’s Division of Neuropharmacological Drug Products (DNDP) does not believe that the evidence currently available allows such a ranking.

The ADA concluded that aripiprazole and ziprasidone have no effect on the risk of diabetes. The ADA notes that because these two drugs have not been included in epidemiological studies, this conclusion is solely based on data from clinical trials that did not …
Analysis of cerebrospinal fluid from patients with psychiatric and neurological disorders by two‐dimensional electrophoresis: Identification of disease‐associated polypeptides as fibrin fragments (1991)

Two-dimensional electrophoresis (2-DE) of cerebrospinal fluid (CSF) samples--from 347 patients with various psychiatric and neurological disorders--and subsequent silver staining revealed two additional polypeptides (Mr 40,000) in 49% of 111 schizophrenics, 46% of 43 schizoaffective patients, 36% of 41 patients with affective disorders, 43% of 28 patients with multiple sclerosis, but not in 25 patients without neurological symptomatology, nor in 9 patients with Lues, and in only 2 of 25 patients with AIDS. The two polypeptides, as detected by 2-DE, eluted after size exclusion chromatography in fractions containing proteins with Mr greater than 200,000. After 2-DE of CSF samples, enriched by gel chromatography, the polypeptides were immobilized by blotting onto glass-fiber membranes and subjected to N-terminal sequencing. Polypeptide A was identified as beta-chain remnant (beta 2), derived from plasmin cleavage of fibrin(ogen). After size exclusion chromatography, 2-DE, and Western blotting, polypeptide A and B, as well as several other spots, reacted with fibrinogen antibodies, suggesting that the polypeptides are subunits of a fibrin degradation complex.
Selective antitumor activity of MKT‐077, a delocalized lipophilic cation, on normal cells and cancer cells in vitro (1998)

Background and Objectives 1-Ethyl-2-{[3-ethyl-5-(3-methylbenzothiazolin-2-yliden)]-4-oxothiazolidin-2-ylidenemethyl}pyridium chloride (MKT-077, formerly known as FJ776), a delocalized lipophilic cation, is known to accumulate in the mitochondria, according to the negative potential inside the mitochondria, and exert its cytotoxicity. Methods The single-cell suspensions of human cancer cell lines, human spleen cells, and fresh cancer specimens obtained from patients with gastric carcinoma were used for the 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H tetrazolium bromide (MTT) assay. Results The antitumor activity of MKT-077 was dose and concentration related, and 50% inhibitory concentrations (IC50) ranged from 1.7 to 14.3 μg/ml, with a mean ± standard deviation (SD) of 8.4 ± 4.6 μg/ml. The IC50 of fresh surgical spleen-cell specimens ranged from 0.34 μg/ml to >100 μg/ml in a 48 h incubation, with a mean ± SD of 66.5 ± 37.7 μg/ml. When the antitumor activity of MKT-077 was compared between gastric cancer cells and spleen cells obtained from the same patient, the concentration-dependent antitumor activity of this agent was obvious in the cancer cells, while no significant cytotoxicity was observed in the spleen cells. The fresh surgical specimens of gastric cancer showed higher sensitivity to MKT-077 than did spleen cells at a concentration of 30 μg/ml, with a statistically significant difference at P < 0.05. Conclusions The selective antitumor activity of MKT-077 was confirmed using fresh surgical specimens and warrants further investigation. J. Surg. Oncol. 1998;69:105–110. © 1998 Wiley-Liss, Inc.
Clinical and Epidemiological Aspects of Alzheimer's Disease with Presenile Onset: A Case Control Study (1990)

Little is known regarding the pathogenetic factors for Alzheimer's disease (AD). We studied 63 AD patients in order to evaluate if there were clinical subtypes of AD and whether prior illnesses and life-styles were involved in the development of the disease. In our patients selected for onset of symptoms before age 65 we did not find any significant clinical heterogeneity. Furthermore, we found no data in the medical history that are predictive for the development of presenile AD but observed a significantly increased frequency of dementia in the families of AD patients in comparison to controls.
Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions (2013)

The neonatal Fc receptor (FcRn) directs the transfer of maternal immunoglobulin G (IgG) antibodies across the placenta and thus provides the fetus and newborn with passive protective humoral immunity. Pathogenic maternal IgG antibodies will also be delivered via the placenta and can cause alloimmunity, which may be lethal. A novel strategy to control pathogenic antibodies would be administration of a nondestructive IgG antibody blocking antigen binding while retaining binding to FcRn. We report on 2 human IgG3 antibodies with a hinge deletion and a C131S point mutation (IgG3ΔHinge) that eliminate complement activation and binding to all classical Fcγ receptors (FcγRs) and to C1q while binding to FcRn is retained. Additionally, 1 of the antibodies has a single point mutation in the Fc (R435H) at the binding site for FcRn (IgG3ΔHinge:R435H). We compared transplacental transport with wild-type IgG1 and IgG3, and found transport across trophoblast-derived BeWo cells and ex vivo placenta perfusions with hierarchies as follows: IgG3ΔHinge:R435H>wild-type IgG1≥IgG3ΔHinge and IgG3ΔHinge:R435H=wild-type IgG1=wild-type IgG3>>>IgG3ΔHinge, respectively. Collectively, IgG3ΔHinge:R435H was transported efficiently from the maternal to the fetal placental compartment. Thus, IgG3ΔHinge:R435H may be a good candidate for transplacental delivery of a nondestructive antibody to the fetus to combat pathogenic antibodies.
Modelling Perceptual Elements of Music in a Vibrotactile Display for Deaf Users: A Field Study (2009)

The model human cochlea (MHC) is a sensory substitution technique for presenting music as multiple discrete channels of vibrotactile stimuli. The MHC prototype was introduced to a group of deaf senior citizens at a community centre, where they could try the chair, and provide us with feedback about their experience. Preliminary results from this work suggest that the MHC can potentially offer a more effective means of expressing basic emotional information from music in a vibrotactile display when the signals more closely match the perceptual elements of the music such as melody and instrument parts. We describe the MHC prototype and present the results of our field study, which extends our lab experiments with the MHC to include deaf and hard of hearing participants in a real world setting.