gebhart/patrepeval huggingface dataset:
Priority queueing in RAID disk arrays with an NVS cache (2002)

We consider a cached RAID5 disk array which partially consists of non-volatile storage (NVS) providing a fast-write capability. Blocks written in this manner are destaged from the NVS cache onto disk asynchronously and at a lower priority than disk read requests. We consider three queueing disciplines to prioritize read misses with respect to destages: (i) Non-preemptive priorities. (ii) Preemptions only after completion of a seek (split-seek option). (iii) Preemption during the latency phase (split-latency option). It can be concluded from the simulation results for two workloads that unlike the FCFS policy, the increase in read response time for all three disciplines is quite moderate up to the point of full disk utilization. This improvement in read response time is at the cost of some wasted processing, but it is shown by applying the vacationing server model to the split-seek option that the reduction in the maximum throughput with respect to the FCFS policy is negligibly small.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Media-based navigation with generic links (1996)

Article Media-based navigation with generic links Share on Authors: Paul H. Lewis The Multimedia Research Group, Department of Electronics and Computer Science, University of Southampton, England, SO171BJ The Multimedia Research Group, Department of Electronics and Computer Science, University of Southampton, England, SO171BJView Profile , Hugh C. Davis The Multimedia Research Group, Department of Electronics and Computer Science, University of Southampton, England, SO171BJ The Multimedia Research Group, Department of Electronics and Computer Science, University of Southampton, England, SO171BJView Profile , Steve R. Griffiths View Profile , Wendy Hall The Multimedia Research Group, Department of Electronics and Computer Science, University of Southampton, England, SO171BJ The Multimedia Research Group, Department of Electronics and Computer Science, University of Southampton, England, SO171BJView Profile , Rob J. Wilkins The Multimedia Research Group, Department of Electronics and Computer Science, University of Southampton, England, SO171BJ The Multimedia Research Group, Department of Electronics and Computer Science, University of Southampton, England, SO171BJView Profile Authors Info & Claims HYPERTEXT '96: Proceedings of the the seventh ACM conference on HypertextMarch 1996 Pages 215–223https://doi.org/10.1145/234828.234849Online:01 March 1996Publication History 27citation418DownloadsMetricsTotal Citations27Total Downloads418Last 12 Months4Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Secure Log Storage Using Blockchain and Cloud Infrastructure (2018)

We are living in the era of information technology. Our day to day life is heavily dependent on it and hence it's safe and secure functioning become very crucial and important. Every minute, there are thousands of cyber-attacks taking place around the world. Attackers are continuously evolving sophisticated and stealthy techniques to target the victim. They takes all the precautionary measures to remove attack traces such as system logs and related information on the victim systems so that they cannot be traced back. Attackers intentionally spread their activities over longer period of time to evade detection. To understand and identify such complex attack, it is required to maintain a secure log records over extended time period. However, preserving the log records for longer time is challenging issue. The system should also ensure the integrity of log files and logging process. In order to overcome these issues, in this paper we are proposing a secure log storage using Blockchain on Cloud platform. Blockchain technology will help to create tamper-proof audit logs. It provides proof of log manipulation and nonrepudiation. Cloud platform makes the overall system scalable and support for deep analysis.
Electron multiplier–scintillator detector for pulse counting positive or negative ions (1978)

A general-purpose ion detector has been developed for fast pulse counting in mass spectrometry. It consists of a six-stage electron multiplier joined to part of a scintillator detector. This novel arrangement combines the virtually noiseless pulse-amplification response of an electron multiplier with the bipolar voltage flexibility of a scintillator detector. The resulting hybrid detector is superior in performance to either an electron multiplier or a conventional scintillator detector. It is designed to detect a beam of positive ions or negative ions focused to a line image or to a spot at the focal plane of a mass analyzer. Background counting noise is less than 1 count/min when the detector is used in either the positive ion or negative ion detecting mode. Mass-resolved ions are post-accelerated through an electric field to give them an additional kinetic energy of 10 keV before they strike the ion-to-electron converter in the electron multiplier. This allows low-energy ions to be detected with an efficiency close to unity, over a range of ion masses from 1 amu up to several hundred amu. Randomly spaced pulses can be counted at rates from 0 Hz to 10 MHz. The design of the detector and its operating characteristics are discussed.
The glycan processing and site occupancy of recombinant Thy-1 is markedly affected by the presence of a glycosylphosphatidylinositol anchor (1999)

Thy-1 is a cell surface glycoprotein containing three N-linked glycosylation sites and a glycosylphosphatidylinositol (GPI) anchor. The effect of the anchor on its N-linked glyco-sylation was investigated by comparing the glycosylation of soluble recombinant Thy-1 (sThy-1) with that of recombinant GPI anchored Thy-1, both expressed in Chinese hamster ovary cells. The sThy-1 was produced in a variety of isoforms including some which lacked carbohydrate on all three sequons whereas the GPI anchored form appeared fully glycosylated like native Thy-1. This was surprising as the attachment of N-linked sugars occurs cotranslationally and it was not expected that the presence of a C-terminal GPI anchor signal sequence would affect sequon occupancy. Furthermore sThy-1 lacking glycosylation could be produced with the inhibitor tunicamycin but in contrast cell surface expression of unglycosylated GPI anchored Thy-1 could not be obtained. The GPI anchored form appeared less processed with almost 4-fold more oligo-mannose oligosaccharides than in sThy-1 and also with less sialylated and core fucosylated biantennary glycans. Possible mechanisms whereby the anchor or the anchor signal sequence, control site occupancy and maturation are discussed.
Machine Learning Approach to Classify Water Cut Measurements using DAS Fiber Optic Data (2019)

Abstract A crucial part of optimizing well production is accurate flow metering for both onshore and offshore environments. The industry currently relies on test separators and multiphase meters. These methods have limitations in terms of cost, transportation and safety. In this paper, an alternative method to classify water cut measurement in oil wells based on Distributed Acoustic Sensing (DAS) data and machine learning will be discussed. Fiber optics is an effective tool to perform downhole logging, however, the challenge usually resides in the analysis and processing of the logged data. After performing a flowing survey on an oil well a dataset was developed using the logged DAS data in combination with production logging tool (PLT) measurements. After extraction, processing and labeling the raw DAS data, this dataset is used for training supervised machine learning models. In this paper, different classical machine learning models to train this dataset is assessed in terms of accuracy, speed and training/testing segments. The data gathered from the PLT shows a limitation in the variation of water cut percentages between the zones ranging from 71% to 76%. This limits our ability to assess the validity of the model, risk of overfitting, since most points share a similar target value. This is also reflected on the Rayleigh backscatter collected by the laser box where samples from different production zones share a similar value distribution across most frequency ranges. Three different classification machine learning models were selected simple Decision Tree and two ensemble method models—adaptive boost and Random Forest. The ensemble method models offer a parallel and sequential training schemes that increases the variance and reduce the bias in the model. After splitting and shuffling the data, were 10% of the original data was used for training, all models were trained in different percentages of the training set. Multiple metrics were chosen to assess the model's performance including accuracy, F-score and confusion matrices. Random forest classifier appears to be the best choice for this challenge, with a maximum accuracy of 98% and F-score of 0.99. The models show high dependency on low frequencies—lower than 500 Hz—where value distribution across production zones in DAS measurements is comparatively higher. Both ensemble method models are less bias with a maximum feature weight of about 0.1, in contrast, the simple Decision Tree model was highly dependent on a single frequency response. In future work, a more complex and diverse dataset will be collected from wells with a wider range of variances in terms of conditions and types. Moreover, after creating a more robust dataset alternative approaches can be assessed both classical machine learning models—regression and classification—and deep learning.
Synthetic Nucleosides and Nucleotides. XX<sup>1</sup>. Synthesis of Various 1-β-<u>D</u>-Xylofuranosyl-5-Alkyluracils and Related Nucleosides (1982)

Abstract Treatment of D-xylose (1) with 0.5% methanolic hydrogen chloride under controlled conditions followed by benzoylation and acetolysis afforded crystalline 1-O-acetyl-2, 3, 5-tri-O-benzoyl-α-D-xylofuranose (4) in good yield. Coupling of 4 with 2, 4-bis-trimethylsilyl derivatives of 5-alkyluracils (methyl, ethyl, propyl and butyl) (5a-5d), 5-fluorouracil (5e) and uracil (5f) in acetonitrile in the presence of stannic chloride gave 1-(2,3,5-tri-O-benzoyl-β-D-xylofuranosyl)-nucleosides (6a-6f). Saponification of 6 with sodium methoxide afforded 1-β-D-xylofuranosyl-5-substituted uracils (7a-7f). Condensation of 4 with free adenine in similar fashion and deblocking gave carcinostatic 9-β-D-xylofuranosyladenine (7g).
Vapor-Liquid Critical Properties of Elements and Compounds. 3. Aromatic Hydrocarbons (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVapor-Liquid Critical Properties of Elements and Compounds. 3. Aromatic HydrocarbonsConstantine Tsonopoulos and Douglas AmbroseCite this: J. Chem. Eng. Data 1995, 40, 3, 547–558Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/je00019a002https://doi.org/10.1021/je00019a002research-articleACS PublicationsRequest reuse permissionsArticle Views728Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Patient Persistency with Pharmacotherapy in the Management of Glaucoma (2003)

Patients initially treated with latanoprost monotherapy are more persistent than those who begin treatment with beta-blockers, brimonidine, or the carbonic anhydrase inhibitor dorzolamide. Greater persistency with an initial ocular hypotensive therapy may improve health outcomes and reduce long-term costs to patients and health plans by limiting the increased resource use associated with discontinuations or changes in therapy.
Cloud Service Security &amp; application vulnerability (2015)

Cloud computing is one of today's most appealing technology areas due to its cost-efficiency and flexibility. However, despite significant interests, deploying cloud computing in an enterprise infrastructure offers significant security concerns. Successful implementation of cloud computing in an enterprise requires proper planning and understanding of emerging risks, threats, vulnerabilities, and possible countermeasures. This paper discusses security concerns of the three cloud computing models namely “Software as a Service” (SaaS), Platform as a Service” (PaaS) and “Infrastructure as a Service” (IaaS). It also discusses Cloud-based Security Tools currently available today. Under the U.S. Federal Security Requirements for Cloud Security. The paper demonstrated the Federal Information Security Management Act (FISMA) and the Federal Risk and Authorization Management Program (FedRAMP). The paper also discusses Cloud Data Encryption, Homomorphic Encryption and Access Control (Identity Access Management). Finally, this paper talks about cloud applications focusing on select cloud applications. It also looks at some of the known vulnerability issues associated with the applications and also the future of cloud applications.
Inter-active graphic methods for automating mechanical engineering design and analyses (1980)

Automating of mechanical engineering design, drafting, structural modelling and analyses is being implemented at EOSC with interactive graphic time share terminals. It was recognized that for reducing costs in mechanical engineering tasks and to stay competitive in the industry, these tasks had to be automated. Previously these tasks used labor intensive manual design and drafting methods, and structural modelling with batch processing. Trade-off evaluations and vendor surveys were conducted of several automated drafting and structural modelling systems. The decisions made after the evaluations was to use currently available soft-ware and Tektronix terminal equipment for inter-active communications with host computers. This paper discusses how mechanical design, and structural modelling and analyses have been automated at EOSC using inter-active graphics and time-share terminals.
Inferring network structure from cascades (2017)

Many physical, biological, and social phenomena can be described by cascades taking place on a network. Often, the activity can be empirically observed, but not the underlying network of interactions. In this paper we offer three topological methods to infer the structure of any directed network given a set of cascade arrival times. Our formulas hold for a very general class of models where the activation probability of a node is a generic function of its degree and the number of its active neighbors. We report high success rates for synthetic and real networks, for several different cascade models.
Regulation of cancer cell motility through actin reorganization (2005)

Cell migration is a critical step in tumor invasion and metastasis, and regulation of this process will lead to appropriate therapies for treating cancer. Cancer cells migrate in various ways, according to cell type and degree of differentiation. The different types of cell migration are regulated by different mechanisms. Reorganization of the actin cytoskeleton is the primary mechanism of cell motility and is essential for most types of cell migration. Actin reorganization is regulated by Rho family small GTPases such as Rho, Rac, and Cdc42. These small GTPases transmit extracellular chemotactic signals to downstream effectors. Of these downstream effectors, Wiskott-Aldrich syndrome protein (WASP) family proteins are key regulators of cell migration. Activated WASP family proteins induce the formation of protrusive membrane structures involved in cell migration and degradation of the extracellular matrix. Inhibition of Rho family small GTPase signaling suppresses the migration and invasion of cancer cells. Thus, control of cell migration via the actin cytoskeleton provides the possibility of regulating cancer cell invasion and metastasis.
Electrocardiogram-based automatic sleep staging in sleep disordered breathing (2003)

A system for electrocardiogram (ECG) based sleep staging in subjects with sleep-disordered breathing is described. Three sleep states are defined: wakefulness(W), REM sleep(R) and non-REM sleep. Features investigated include RR interval, RR standard deviation, RR spectra, respiratory frequency, RR interval differences, and an ECG-derived respiratory signal. A subject specific quadratic discriminant classifier was trained and tested, and yielded an estimated classification accuracy of 71% (Cohen's /spl kappa/ value of 0.37). When a similar subject-dependent classifier was trained and tested, the estimated classification accuracy dropped to 61% (/spl kappa/=0.12). For comparison, an electroencephalogram (EEG) based classifier yielded a subject-specific accuracy of 76% (/spl kappa/=0.51), and subject-independent accuracy of 75% (/spl kappa/=0.43), indicating that EEG features are robust across subjects. We conclude that the ECG signal provides moderate sleep-staging accuracy, but features exhibit significant subject dependence.
A Fortuitous Extra-Analytic Event: (1986)

No abstract available for this article.
ChemInform Abstract: SYNTHESIS AND STRUCTURE OF AROMATIC AND HETEROCYCLIC TELLURIUM COMPOUNDS. XXII. NEW SYNTHESIS OF DIARYLTELLURIUM DICHLORIDES (1983)

Abstract Teilweise in Anlehnung an Literaturverfahren, die weiterentwickelt werden,‐werden Synthesen der asymm. und der symm. Diaryltellurdihalogenide (III) sowie der asymm. Arylidenaryltellurdichloride (VI) angegeben, die auf der Umsetzung der Telluride (I) bzw. (V) mit den Aryldiazoniumverbindungen (II) in Gegenwart von Kupfersalzen beruhen.
Epidural Spinal Cord Stimulation in the Management of Spasms in Spinal Cord Injury: A Prospective Study (1995)

Forty-eight spinal cord injury victims were implanted with an epidural spinal cord stimulation system to treat spasms that had not satisfactorily responded to medical therapy. All the patients were at least 6 months after the injury. The protocol included assessment by independent examiners preoperatively and at 3, 6, 12 and 24 months after the implant. Pre- and postoperative data collection included the frequency and severity of the spasms. Combining the frequency and intensity scores into a 'severity' score provided a more accurate clinical picture. No patient observed neurological deterioration following the surgical procedure or the neurostimulation treatment. A statistically significant reduction in the severity of the spasms was observed in the follow-up evaluations, with results that progressively increased in time. It is appears that spinal cord stimulation is an effective and safe alternative in the management of spasms in spinal cord injury victims. Its exact role in relation to intrathecal baclofen infusion and ablative procedures remains to be defined.
Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing (2018)

Capable of mediating efficient transfection and protein production without eliciting innate immune responses, chemically modified mRNA holds great potential to produce paracrine factors at a physiologically beneficial level, in a spatiotemporally controlled manner, and with low toxicity. Although highly promising in cardiovascular medicine and wound healing, effects of this emerging therapeutic on the microvasculature and its bioactivity in disease settings remain poorly understood. Here, we longitudinally and comprehensively characterize microvascular responses to AZD8601, a modified mRNA encoding vascular endothelial growth factor A (VEGF-A), in vivo. Using multi-parametric photoacoustic microscopy, we show that intradermal injection of AZD8601 formulated in a biocompatible vehicle results in pronounced, sustained and dose-dependent vasodilation, blood flow upregulation, and neovessel formation, in striking contrast to those induced by recombinant human VEGF-A protein, a non-translatable variant of AZD8601, and citrate/saline vehicle. Moreover, we evaluate the bioactivity of AZD8601 in a mouse model of diabetic wound healing in vivo. Using a boron nanoparticle-based tissue oxygen sensor, we show that sequential dosing of AZD8601 improves vascularization and tissue oxygenation of the wound bed, leading to accelerated re-epithelialization during the early phase of diabetic wound healing.
Interleukin-15: a novel anabolic cytokine for skeletal muscle. (1995)

Interleukin-15 (IL-15) is a recently discovered growth factor which is highly expressed in skeletal muscle. In order to determine a functional role for IL-15 in skeletal myogenesis, the effects of IL-15 on myoblast proliferation and muscle-specific myosin heavy chain (MHC) expression were analyzed using the mouse C2 skeletal myogenic cell line and primary fetal bovine skeletal myogenic cultures. IL-15 had no effect on [3H]thymidine incorporation, nor on the rate of myoblast differentiation, assessed by anti-MHC immunocytochemical staining, in either type of culture. However, Western blot analyses revealed that IL-15 used at concentrations of 10 or 100 ng/ml increased MHC accumulation five-fold in C2 myoblast cultures and 2.5-fold in primary bovine myogenic cultures. Moreover, C2 myotubes formed in the presence of IL-15 appeared larger than controls. These findings indicate IL-15 can stimulate differentiated myocytes and muscle fibers to accumulate increased amounts of contractile proteins. Well-fused primary bovine myogenic cultures treated with the mitotic inhibitor aphidicolin, then administered IL-15 and/or the anabolic growth factor insulin-like growth factor-I (IGF-I), were analyzed for MHC accumulation using Western blots. IL-15 used at 10 ng/ml doubled MHC accumulation and was as effective as IGF-I used at 10 or 100 ng/ml. IL-15 and IGF-I used together increased MHC accumulation close to five-fold, indicating these two factors can act additively on muscle fibers. These findings indicate IL-15 affects parameters associated with skeletal muscle fiber hypertrophy, and suggest that IL-15 may be a novel anabolic agent to increase skeletal muscle mass.
Biotemplate Synthesis of 3-nm Nickel and Cobalt Nanowires (2003)

Large biomolecules are attractive templates for the synthesis of metal1-7 and inorganic8-10 compound nanostructures. The well-defined chemical and structural heterogeneity of the biotemplates can be exploited for the precise control of the size and shape of the formed nanostructures. Here, we demonstrate that the central channel of the tobacco mosaic virus (TMV) can be used as a template to synthesize nickel and cobalt nanowires only a few atoms in diameter, with lengths up to the micrometer range.