gebhart/patrepeval huggingface dataset:
Conjugated Polymer Amplified Far‐Red/Near‐Infrared Fluorescence from Nanoparticles with Aggregation‐Induced Emission Characteristics for Targeted In Vivo Imaging (2012)

Fluorescence-amplified far-red/near-infrared (FR/NIR) nanoparticles (NPs) are synthesized by co-encapsulation of conjugated polymer donor (poly[9,9-bis(2-(2-(2-methoxyethoxy)ethoxy)ethyl)fluorenyldivinylene]; PFV) and a fluorogen acceptor (2-(2,6-bis((E)-4-(phenyl(4'-(1,2,2-triphenylvinyl)-[1,1'-biphenyl]-4-yl)amino)styryl)-4H-pyran-4-ylidene)malononitrile; TPE-TPA-DCM) with aggregation-induced emission (AIE) characteristics using biocompatible bovine serum albumin (BSA) as the encapsulation matrix. The good spectral overlap and close proximity between PFV and TPE-TPA-DCM in BSA NPs result in a 5.3-fold amplified TPE-TPA-DCM emission signal via fluorescence resonance energy transfer (FRET). The obtained PFV/TPE-TPA-DCM co-loaded BSA NPs are spherical in shape with a large Stokes shift of ∼223 nm and low cytotoxicity. The BSA matrix allows further functionalization with arginine-glycine-aspartic acid (RGD) peptide to yield fluorescent probes for specific recognition of integrin receptor-overexpressed cancer cells. The advantage of PFV amplified FR/NIR signal from TPE-TPA-DCM is further demonstrated in cellular and in vivo imaging using HT-29 colon cancer cells and a murine hepatoma H22 tumor-bearing mouse model, respectively. The high FR/NIR fluorescence and specific cancer targeting ability by RGD surface functionalization make the PFV/TPE-TPA-DCM co-loaded BSA-RGD NPs a unique FR/NIR fluorescent probe for cellular imaging and in vivo tumor diagnosis in a high contrast and selective manner.
Lipids, membranes and aspects of photobiology (1990)

Fatty acids - structural identification, F.D.Gunstone triacyglycerol biosynthesis, A.K.Stobart and S.Stymne phospholipids, T.S.Moore glycolipid analyses and aynthesis in plants, R.Douce et al waxes, suberins, and cutins, T.J.Walton polyacetylenes and related compounds, J.Lam and L.Hansen phytochrome and other receptors, L.H.Pratt et al absorption techniques in the study of photosynthesis, P.Mathis chlorophyll flourescence transients, P.Horton and J.R.Bowyer structure and dynamics of plant membranes, P.J.Quinn and W.P.Williams.
Reduced expression of transforming growth factor‐β receptors is an unfavorable prognostic factor in human esophageal squamous cell carcinoma (2003)

Transforming growth factor-beta (TGF-beta) inhibits epithelial cell proliferation. Inactivation of the TGF-beta signaling pathway is thought to play a role in tumorigenesis. Our purpose was to clarify the correlation between TGF-beta receptors or TGF-beta 1 expression and the clinicopathologic characteristics of patients with esophageal squamous cell carcinoma (SCC). Immunohistochemical staining for TGF-beta type I receptor (TGF-beta R-I), TGF-beta R-II and TGF-beta 1 was performed on surgical specimens obtained from 80 patients with esophageal SCC. Preoperative plasma TGF-beta1 levels were measured and correlated with pathologic features and clinical outcomes. Expression of TGF-beta R-I and TGF-beta R-II was reduced in 43 (53.8%) and 23 (28.8%) specimens, respectively. TGF-beta 1 was overexpressed in 29 (36.3%). Reduced expression of TGF-beta R-I and TGF-beta R-II showed a significant association with depth of invasion (p = 0.0015 and p = 0.0012), lymph node metastasis (p = 0.0309 and p = 0.0059) and pathologic stage (p = 0.0103 and p = 0.0401). Overexpression of TGF-beta 1 had a significant association with depth of invasion only (p = 0.0335). Reduced expression of TGF-beta R-I and TGF-beta R-II was correlated with cancer-specific survival (p = 0.0324 and p = 0.0243). The mean preoperative plasma TGF-beta 1 level was 10.5 +/- 0.8 ng/ml in patients with esophageal carcinoma and was significantly higher compared to healthy controls (p < 0.01). We demonstrate that reduced expression of TGF-beta receptors in esophageal SCC appears to be correlated with depth of invasion, lymph node metastasis, pathologic stage and poor prognosis. TGF-beta receptor expression may play a key role in the progression of this cancer.
Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells (2022)

Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in the generation of stem-cell-derived islets (SC-islets), no detailed characterization of their functional properties has been conducted. Here, we generated functionally mature SC-islets using an optimized protocol and benchmarked them comprehensively against primary adult islets. Biphasic glucose-stimulated insulin secretion developed during in vitro maturation, associated with cytoarchitectural reorganization and the increasing presence of alpha cells. Electrophysiology, signaling and exocytosis of SC-islets were similar to those of adult islets. Glucose-responsive insulin secretion was achieved despite differences in glycolytic and mitochondrial glucose metabolism. Single-cell transcriptomics of SC-islets in vitro and throughout 6 months of engraftment in mice revealed a continuous maturation trajectory culminating in a transcriptional landscape closely resembling that of primary islets. Our thorough evaluation of SC-islet maturation highlights their advanced degree of functionality and supports their use in further efforts to understand and combat diabetes.
Preisverleihungen der DPG 1986/Neues Versandverfahren für die Physikalischen Blätter/Post‐Deadline‐Sitzung des Fachausschusses Oberflächenphysik in Freudenstadt (1986)

Abstract Die Deutsche Physikalische Gesellschaft verleiht 1986 acht Preise, über die im folgenden berichtet wird. Der Otto‐Hahn‐Preis für Chemie und Physik, die Max‐Planck‐Medaille, der Gentner‐Kastler‐Preis, der Physikpreis und der Didaktik‐Preis werden auf der Festsitzung der 50. Physikertagung am 19. März 1986 in Heidelberg vom DPG‐Präsidenten, Herrn Professor Dr. Joachim Treusch, überreicht; der Walter‐Schottky‐Preis wird auf der Plenarsitzung der Frühjahrstagung des Arbeitskreises Festkörperphysik am 9. April 1986 in Freudenstadt verliehen. Darüber hinaus vergibt die Physikalische Gesellschaft zu Berlin jährlich den Karl‐Scheel‐Preis. Er wurde im Rahmen eines Festkolloquiums im Februar in Berlin vom Vorsitzenden des Regionalverbandes Berlin, Herrn Prof. Dr. Gerhard Hildebrandt, überreicht. Der gemeinsame Preis der DPG und des Institute of Physics (IOP), der Max‐Born‐Preis, wird im Mai dieses Jahres vom IOP in London verliehen.
A Mobile Edge Computing-based architecture for improved adaptive HTTP video delivery (2016)

Dynamic Adaptive Streaming over HTTP (DASH) is currently a widely adopted technology for video delivery over the Internet. DASH offers significant advantages, enabling users to switch dynamically between different available video qualities responding to variations in the current network conditions during video playback. This is particularly interesting in wireless and mobile access networks, which present unexpected and frequent such variations. Moreover, mobile users in these networks share a common radio access link and, thus, a common bottleneck in case of congestion, which may cause user experience to degrade. In this context, the Mobile Edge Computing (MEC) emerging standard gives new opportunities to improve DASH performance, by moving IT and cloud computing capabilities down to the edge of the mobile network. In this paper, we propose a novel architecture for adaptive HTTP video streaming tailored to a MEC environment. The proposed architecture includes an adaptation algorithm running as a MEC service, aiming to relax network congestion while improving user experience. Our mechanism is standards-compliant and compatible with receiver-driven adaptive video delivery algorithms, with which it cooperates in a transparent manner.
Mapping of β‐adrenoceptor coupling domains to G<sub>s</sub>‐protein by site‐specific synthetic peptides (1989)

Peptides corresponding to the known sequence of turkey erythrocyte beta 1-adrenergic receptor were synthesized and the effects on receptor-mediated cyclase activation were measured. Peptides corresponding to the first and second intracellular loops (T61-71 and T138-159) inhibited at micromolar concentrations the hormone-dependent cyclase activation in turkey erythrocyte membranes. In contrast, the peptide corresponding to the C-terminal part of the third intracellular loop (T284-295) increased the cyclase activity in a hormone-independent manner. Peptides T338-353 and T2-10 and a number of synthetic peptides unrelated to the beta-adrenoceptor had no effect.
Limited degradation of chlorophenols by anaerobic sludge granules (1992)

To better understand the fate of chlorophenols treated in upflow anaerobic sludge bed reactors, we examined the ability of sludge granules from such bioreactors to degrade two trichlorophenols and one dichlorophenol in batch incubations under controlled conditions. Biodegradation was primarily limited to two distinct activities, reductive dehalogenation of ortho- and of meta-chlorine substituents. Both 3- and 4-monochlorophenol were persistent degradation products, while 2-monochlorophenol was further degraded. We also examined factors potentially affecting the rate and extent of 2,3,6-trichlorophenol degradation. An initial concentration of up to 1.75 mM (346 mg/liter) was dehalogenated. At that concentration, dehalogenation was partially inhibited but methanogenesis from formate was not. The initial concentration affected both the extent of dehalogenation and which products were detected. The maximum dechlorination rate observed was 1.4 mumol of Cl- h-1 g of volatile suspended solids-1. Dechlorination had a temperature optimum of 50 degrees C, was inhibited by added electron acceptors, and was not appreciably affected by added electron donors. The availability of electron acceptors and electron donors did not affect the extent of chlorophenol degradation. These particular sludge granules do not appear to be capable of mineralizing phenols with meta- or para-chlorine substituents.
Reference image-independent fault detection in transportation camera systems for nighttime scenes (2012)

Automated, unattended camera systems used for various transportation applications such as toll collection and photo enforcement need to capture high quality images in a variety of outdoor scenarios. In particular, they need to remain functional in low ambient illumination conditions (nighttime and cloudy day situations) to enable identification of objects or persons involved in incidents being monitored or extracting relevant information. Over time, for installed camera systems in the field, several problems can develop, such as external flash unit failures, focus drifts, and exposure issues. Thus, it is important to periodically monitor the nighttime images/videos taken by the camera system to ensure nominal functionality. However, due to constantly changing scene elements, it is not practical to compare a historical reference image with an identical scene against current camera output to detect problems. To address this, we present image quality metrics that can be extracted without a nominal reference image and can be used to characterize these problems. These can be incorporated into algorithms that can enable automated camera diagnostics for intelligent transportation systems.
Olaparib modulates DNA repair efficiency, sensitizes cervical cancer cells to cisplatin and exhibits anti-metastatic property (2017)

PARP1 trapping at DNA lesion by pharmacological inhibitors has been exploited in several cancers exhibiting defects in DNA repair mechanisms. PARP1 hyperactivation is involved in therapeutic resistance in multiple cancers. The role of PARP1 in cervical cancer (CC) resistance and implication of PARP inhibitor is yet to be elucidated. Our data demonstrates significantly higher expression of PARP1 in primary cervical tumors and CC cell lines SiHa and ME180. Upon cisplatin treatment CC cells display significant overexpression of PARP1 and its hyperactivation. PARP inhibitor olaparib shows significant anti-proliferative effect on CC cells and drive loss of clonogenic survival and enhanced cell death in combination with cisplatin. PARP inhibited cells show delay in resolution of γH2A.X foci and prolonged late S and G2-M phase arrest resulting in apoptosis. Further, PARP inhibition disrupts the localization of base excision repair (BER) effector XRCC1 and non-homologous end joining (NHEJ) proteins Ku80 and XRCC4. Due to disrupted relocation of repair factors, cisplatin induced stalled replication forks collapse and convert into double strand breaks (DSBs). Interestingly, PARP inhibition also shows anti-migratory and anti-invasive properties in CC cells, increases anchorage independent cell death and induces anoikis. Collectively, our data demonstrates therapeutic potential of PARP inhibitor in cervical cancer.
邦産クビボソジョウカイ属の再検討 (I) (昆虫綱, 鞘翅目, ジョウカイボン科) (1981)

departmental bulletin paper
A Hierarchical Track and Hold Circuit for High Speed ADC-Based Receivers in 22nm FDSOI (2019)

A Hierarchical Time-Interleaved (TI) track and hold (T&H) circuit for ultra high speed ADC-based wireline receivers is presented. The circuit is designed as a front-end of a 7-bit 56 GS/s 64-way TI ADC. It consists of three T&H stages of demultiplexing sampled at 28GHz, 3.5 GHz and 875 MHz, respectively. The overall SNR is limited by the sampling capacitors, which are sized to meet the link budget. The T&H stages were designed in 22 nm FDSOI while consuming 90.1 mW.
Maximizing potential shouldn't negate happiness: Gifted children need stimulation and support (1996)

Initially, the call Debra Hill received last spring from a mother who thought her child was gifted didn9t seem out of the ordinary. A public school district assistant superintendent of curriculum and instruction, Hill is well-versed in special services for gifted children, so the parent9s questions seemed typical: What resources did the district have? How were gifted children tracked? What activities should she and her husband do with the child at home to ensure eligibility for the gifted program? What was unusual was the timing of the mother9s call.
Towards a practical lipreading system (2011)

A practical lipreading system can be considered either as subject dependent (SD) or subject-independent (SI). An SD system is user-specific, i.e., customized for some particular user while an SI system has to cope with a large number of users. These two types of systems pose variant challenges and have to be treated differently. In this paper, we propose a simple deterministic model to tackle the problem. The model first seeks a low-dimensional manifold where visual features extracted from the frames of a video can be projected onto a continuous deterministic curve embedded in a path graph. Moreover, it can map arbitrary points on the curve back into the image space, making it suitable for temporal interpolation. Based on the model, we develop two separate strategies for SD and SI lipreading. The former is turned into a simple curve-matching problem while for the latter, we propose a video-normalization scheme to improve the system developed by Zhao et al. We evaluated our system on the OuluVS database and achieved recognition rates more than 20% higher than the ones reported by Zhao et al. in both SD and SI testing scenarios.
Silicon-based Sources and Detectors for Terahertz Applications (2014)

Todays terahertz instrumentation lacks cost-effective sources and detectors compatible with standard microelectronics to drive down the system cost. This paper presents recent developments based on silicon process technologies and discusses the challenges in implementing source and detectors. It presents a 530 GHz source array with up to 1 mW radiated power, a 1024-pixel CMOS camera, and a heterodyne 830 GHz imaging chip-sets.
The Durra Application Debugger/Monitor (1989)

Abstract : Durra is a language designed to support the construction of distributed applications using concurrent, coarse-grained tasks running on networks of heterogeneous processors. An application written in Durra describes the tasks to be instantiated and executed as concurrent processes, the types of data to be exchanged by the processes, and the intermediate queues required to store the data as they move from producer to consumer processes. This report describes the Durra application debugger/monitor, a program that works in conjunction with the Durra runtime software to help the developer locate errors and/or performance bottlenecks in a Durra application.
Crystal structure studies on the polymorphic forms of nylons 6 and 8 and other even nylons (1963)

Abstract Polymorphism present in the even nylons has been accounted for in terms of parallel and antiparallel packing of the polyamide chains. Hydrogen bonding appears to play the most important part in governing chain packing. For example, in the antiparallel structure (alternate chains running in opposite directions), complete hydrogen bonding is possible for fully extended planar zigzag nylon chains. In the parallel structure (all chains running in the same direction) complete hydrogen bonding is not possible for the fully extended nylon chains. Hence, the nylon chains twist to satisfy this requirement. This has been shown by interpretation of the x‐ray diffraction pattern of γ‐phase nylon 6. Between nylons 6 and 8 there appears to be a transition between the thermodynamic stabilities of the polymorphic chain packings. Antiparallel chain packing appears to be the common form of nylons 4 and 6. Parallel chain packing appears to be the common form of nylons 8 and 10. Apparently, when sufficient flexibility is given to the even nylon chains by the addition of methylene groups, the twisted chain structure is favored.
Tubuloglomerular feedback in obstructive uropathy. (1991)

The tubuloglomerular feedback (TGF) mechanism was studied in rats with chronic partial ureteral occlusion (hydronephrosis) with the use of the stop-flow pressure techniques and measurements of single nephron glomerular filtration rate. In hydropenic conditions, TGF was normal in hydronephrotic kidneys, but TGF sensitivity and activity increased in response to extracellular volume expansion, which is the opposite of normal resetting. The increased sensitivity may be due to an increased production of thromboxane A2 in the hydronephrotic kidney, since both inhibition of thromboxane synthetase and blockade of thromboxane/prostaglandin endoperoxide receptors normalized the resetting during volume expansion. Pelvic pressure in hydronephrotic kidneys was low in hydropenia and increased moderately during volume expansion. Thromboxane synthesis inhibition before volume expansion allowed pelvic pressure to increase by more than 100% as compared with untreated hydronephrotics. Also, when pelvic pressure increases were prevented during volume expansion, TGF resetting was normalized. An increased thromboxane synthesis during volume expansion may be protective in hydronephrotic kidneys, in that TGF resets to a higher sensitivity to prevent increases in glomerular filtration rate and urine formation which otherwise would increase pelvic pressure. A resetting to a higher sensitivity was also elicited by intraarterial or intratubular administration of bradykinin. This suggests that thromboxane release may be mediated through an increased bradykinin production during volume expansion in hydronephrotics. In contrast, bradykinin resets TGF to a lower sensitivity in control kidneys.
Wireless Solar Water Splitting Using Silicon-Based Semiconductors and Earth-Abundant Catalysts (2011)

We describe the development of solar water-splitting cells comprising earth-abundant elements that operate in near-neutral pH conditions, both with and without connecting wires. The cells consist of a triple junction, amorphous silicon photovoltaic interfaced to hydrogen- and oxygen-evolving catalysts made from an alloy of earth-abundant metals and a cobalt|borate catalyst, respectively. The devices described here carry out the solar-driven water-splitting reaction at efficiencies of 4.7% for a wired configuration and 2.5% for a wireless configuration when illuminated with 1 sun (100 milliwatts per square centimeter) of air mass 1.5 simulated sunlight. Fuel-forming catalysts interfaced with light-harvesting semiconductors afford a pathway to direct solar-to-fuels conversion that captures many of the basic functional elements of a leaf.
Absorber stack with transparent conductive oxide layer for extreme ultraviolet lithography (2009)

In this study, the authors propose transparent conductive oxide layer as a new absorber for extreme ultraviolet lithography mask. The optical constant of indium tin oxide (ITO) at 13.5nm is calculated and the extinction coefficient of ITO is found to be 1.55 times higher than that of TaN, resulting in higher absorption in the absorbing stack. Using an ITO layer in the absorber stack enables to design the attenuated phase-shift masks with smaller height difference of only 32.1nm than the conventional TaN absorber stack of about 80nm between high reflecting and absorbing stacks in extreme ultraviolet lithography, indicating that the geometric shadow effect can be significantly reduced.
Stereoisomerism in Plant Growth Regulators of the Auxin Type (1965)

Crop loss due to soil salinization is an increasing threat to agriculture worldwide. This review provides an overview of cellular and physiological mechanisms in plant responses to salt. We place cellular responses in a time- and tissue-dependent context ...Read More
Coupling of Buoyant Convections in Boron Oxide and a Molten Semiconductor in a Vertical Magnetic Field (2002)

This paper treats the buoyant convection in a layer of boron oxide, called a liquid encapsulant, which lies above a layer of a molten compound semiconductor (melt) between cold and hot vertical walls in a rectangular container with a steady vertical magnetic field B. The magnetic field provides an electromagnetic (EM) damping of the molten semiconductor which is an excellent electrical conductor but has no direct effect on the motion of the liquid encapsulant. The temperature gradient drives counter clockwise circulations in both the melt and encapsulant. These circulations alone would lead to positive and negative values of the horizontal velocity in the encapsulant and melt, respectively, near the interface. The competition between the two buoyant convections determines the direction of the horizontal velocity of the interface. For B=5 T, there is significant EM damping of the melt motion and the encapsulant drives a positive interfacial velocity and a small clockwise circulation in the melt. For a much weaker field B=0.1 T, the maximum velocity in the melt is hundreds of times larger than that of the encapsulant, thus causing nearly all the encapsulant to circulate in the clockwise direction.