gebhart/patrepeval huggingface dataset:
Thermal analysis of vertically integrated circuits (1995)

In this paper, a thermal analysis of Vertically Integrated Circuits (VIC) is presented for the first time. Based on a 1-D model, temperature differences in VICs of less than 10/spl deg/C are evaluated for most practical applications. Detailed 3-D investigations show that self-heating of MOSFETs in the upper chip-layers of a VIC is more pronounced than in bulk CMOS and that it strongly depends on the thickness of the silicon remaining in the chip-layer. In addition, thermal coupling between adjacent transistors is observed to be much more marked.
Genomic structure and characterisation of the promoter region of the human IL-18 gene. (2000)

Interleukin (IL)-18 is a cytokine that plays an important role in the T helper (Th) 1 response, primarily by its ability to induce gamma interferon (IFN-gamma) production by T cells and Natural Killer (NK) cells. It also plays a role in host resistance to infection and in Lipopolysaccharides (LPS)-induced histopathology. By a direct sequencing on P1 Artificial Chromosomes (PAC) clones, we have determined the genomic structure and the promoter region of the human IL-18 gene. The IL-18 gene spans approximately 20 Kb and consists of 6 exous. The 5'-flanking regions of human IL-18 and mouse IL-18 show 75% homology suggesting conserved promoter regulatory factors.
Respiratory syncytial virus G-protein modulates cytokine release from human peripheral blood mononuclear cells (1996)

Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in children and adults. In vivo the host has to cope with intact replicative virus, with non-replicative virus, and/or with viral structural proteins including the outer membrane G-protein. We analyzed the role of purified RSV G-protein with regard to its modulatory efficacy for interleukin (IL) -10, IL-12, and tumor necrosis factor-alpha (TNF-alpha) release from human peripheral blood mononuclear cells (PBMC). These cytokines seem to contribute to the deleterious effect in viral infections. Treatment of PBMC with RSV at a multiplicity of infection of 10 down to 0.001 induced the release of TNF-alpha, IL-10, and IL-12; also time kinetics and dose-responses differed markedly. Stimulation of PBMC with purified RSV G-protein (from 0.001 up to 10 microgram/10(6) PBMC) led only to a pronounced increase in IL-10 within a concentration range from 0.01 up to 0.5 microgram/10(6) PBMC with a maximum between 12 and 18 h of incubation. AT later time points (24, 48, and 72 h) G-protein concentrations above 1 microgram/10(6) PBMC suppressed IL-10, TNF-alpha, and IL-12 release from human PBMC. Coating of PBMC with RSV G-protein suppressed IL-10, TNF-alpha, and IL-12 release after subsequent stimulation with RSV. Our data indicate a regulatory role of RSV G-protein immune responses toward viral infection.
Die Mikroorganismen der Gärungsindustrie (1956)

Book digitized by Google from the library of the University of Michigan and uploaded to the Internet Archive by user tpb.
Peptide Backbone Chemistry and Membrane Channel Function:  Effects of a Single Amide-to-Ester Replacement on Gramicidin Channel Structure and Function (2001)

To examine the structural and functional importance of backbone amide groups in ion channels for subunit folding, hydrogen bonding, ion solvation, and ion permeation, we replaced the peptide bond between Val(1) and Gly(2) in gramicidin A by an ester bond. The substitution is at the junction between the two channel subunits, where it removes an intramolecular hydrogen bond between the NH of Gly(2) and the C==O of Val(7) and perturbs an intermolecular hydrogen bond between the C==O of Val(1) in one subunit and the NH of Ala(5) in the other subunit. The substitution thus perturbs not only subunit folding but also dimer assembly, in addition to any effects on ion permeation. This backbone modification has large effects on channel function: It alters channel stability, as monitored by the channel forming ability and channel lifetime, and ion permeability, as monitored by changes in single-channel conductance and cation permeability ratios. In fact, the homodimeric channels, with two ester-containing subunits, have lifetimes so short that it becomes impossible to characterize them in any detail. The peptide --> ester substitution, however, does not affect the basic subunit fold because heterodimeric channels can form between a subunit with an ester bond and a native subunit. These heterodimeric channels, with only a single ester bond, are more easily characterized; the lone ester reduces the single-channel conductance about 4-fold and the lifetime about 200-fold as compared to the native homodimeric channels. The altered channel function results from a perturbation/disruption of the hydrogen bond network that stabilizes the backbone, as well as the membrane-spanning dimer, and that forms the lining of the ion-conducting pore. Molecular dynamics simulations show the expected destabilization of the modified heterodimeric or homodimeric channels, but the changes in backbone structure and dynamics are remarkably small. The ester bond is somewhat unstable, which precluded further structural characterization. The lability also led to a hydrolysis product that terminates with an alcohol and lacks formyl-Val. Symmetric channels formed by the hydrolyzed product again have short lifetimes, but the channels are distinctly different from those formed by the ester gramicidin A. Furthermore, well-behaved asymmetric channels form between the hydrolysis product and reference subunits that have either an L- or a D-residue at the formyl-NH-terminus.
Decision Support Systems Advances in (2010)

Since the 1970‟s Decision Support Systems (DSS) have become popular following the development in computer technology. A DSS aims to support in the solving of specific problems with both human and computer techniques. The purpose of this research was to design and develop a DSS for application involved with the cost calculations and revenue calculations of contracted timber haulage in Ireland.
Thermomechanical analysis of viscoelastic solids (1970)

Abstract This paper is concerned with the development of a computational algorithm for the solution of the uncoupled, quasi‐static boundary value problem for a linear viscoelastic solid undergoing thermal and mechanical deformation. The method evolves from a finite element discretization of a stationary value problem, leading to the solution of a system of linear integral equations determining the motion of the solid. An illustrative example is included.
Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers (1999)

The ability to separate the isoforms of human tumour suppressor protein p53 expressed in insect cells using heparin-Sepharose correlates with differences in the isoelectric point of p53, demonstrating that p53 can be heterogeneously modified and providing support for the use of insect cells as a model system for identifying novel signalling pathways that target p53. One p53 isoform that was reduced in its binding to the monoclonal antibody DO-1 could be stimulated in its binding to DO-1 by prior incubation with protein phosphatases, suggesting the presence of a previously unidentified N-terminal phosphorylation site capable of masking the DO-1 epitope. A synthetic peptide from the N-terminal domain of p53 containing phosphate at Ser(20) inhibited DO-1 binding, thus identifying the phosphorylation site responsible for DO-1 epitope masking. Monoclonal antibodies overlapping the DO-1 epitope were developed that are specific for phospho-Thr(18) (adjacent to the DO-1 epitope) and phospho-Ser(20) (within the DO-1 epitope) to determine whether direct evidence could be obtained for novel phosphorylation sites in human p53. A monoclonal antibody highly specific for phospho-Ser(20) detected significant phosphorylation of human p53 expressed in insect cells, whereas the relative proportion of p53 modified at Thr(18) was substantially lower. The relevance of these two novel phosphorylation sites to p53 regulation in human cells was made evident by the extensive phosphorylation of human p53 at Thr(18) and Ser(20) in a panel of human breast cancers with a wild-type p53 status. Phospho-Ser(20) or phospho-Thr(18) containing p53 peptides are as effective as the phospho-Ser(15) peptide at reducing mdm2 (mouse double minute 2) protein binding, indicating that the functional effects of these phosphorylation events might be to regulate the binding of heterologous proteins to p53. These results provide evidence in vivo for two novel phosphorylation sites within p53 at Ser(20) and Thr(18) that can affect p53 protein-protein interactions and indicate that some human cancers might have amplified one or more Ser(20) and Thr(18) kinase signalling cascades to modulate p53 activity.
π-Allylpalladium-Mediated Catalytic Synthesis of Functionalized Allenes (2000)

Two sequential palladium-catalyzed reactions enable readily available 1,1-dibromo-1-alkenes to be converted into a variety of functionalized allenes (see scheme). The second step proceeds via a π-allylpalladium intermediate, to which a nucleophile attacks highly selectively to give the allene in excellent yield.
Laboratory Evaluation of Tick Repellents (1973)

Journal Article Laboratory Evaluation of Tick Repellents Get access M. Bar-Zeev, M. Bar-Zeev Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Gothilf S. Gothilf 1Israel Institute for Biological Research, Tel-Aviv University Medical School, Ness-Ziona, Israel Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Medical Entomology, Volume 10, Issue 1, 31 January 1973, Pages 71–74, https://doi.org/10.1093/jmedent/10.1.71 Published: 31 January 1973
Assessment of Collagen Film for Use in Urinary Tract Surgery (1986)

This investigation assessed a biodegradable collagen membrane which can be sutured around the ureter to prevent urine leakage, thus permitting healing to proceed more rapidly while the membrane itself is resorbed. Following an early in vitro investigation in which collagen was assessed, a more comprehensive survey has now been carried out. Tissue compatibility and biodegradation were assessed by implanting the film into the lumbar muscles of rats; it was then used to cover experimental ureterotomies in New Zealand White rabbits. The data obtained from the rabbits confirmed that a collagen membrane can prevent leakage of urine from the ureter during healing while it itself is biodegraded, indicating that a collagen membrane could be used to repair the injured urinary tract.
Polyhomologation. A Living Polymethylene Synthesis (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTPolyhomologation. A Living Polymethylene SynthesisK. J. Shea, J. W. Walker, H. Zhu, M. Paz, and J. GreavesView Author Information Department of Chemistry, University of California Irvine, California 92604 Cite this: J. Am. Chem. Soc. 1997, 119, 38, 9049–9050Publication Date (Web):September 24, 1997Publication History Received18 June 1997Published online24 September 1997Published inissue 1 September 1997https://doi.org/10.1021/ja972009fCopyright © 1997 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1545Altmetric-Citations119LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (118 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Copolymers,Gel permeation chromatography,Hydrocarbons,Polyethylene Get e-Alerts
Robust Low-Power Algorithm for Random Sensing Matrix for Wireless ECG Systems Based on Low Sampling-Rate Approach (2013)

The main drawback of current ECG systems is the location-specific nature of the systems due to the use of fixed/wired applications. That is why there is a critical need to improve the current ECG systems to achieve extended patient’s mobility and to cover security handling. With this in mind, Compressed Sensing (CS) procedure and the collaboration of Sensing Matrix Selection (SMS) approach are used to provide a robust ultra-low-power approach for normal and abnormal ECG signals. Our simulation results based on two proposed algorithms illustrate 25% decrease in sampling-rate and a good level of quality for the degree of incoherence between the random measurement and sparsity matrices. The simulation results also confirm that the Binary Toeplitz Matrix (BTM) provides the best compression performance with the highest energy efficiency for random sensing matrix.
Compact VLSI implementation of cellular neural network (2002)

In this paper a new solution for cellular neural network cell structure is presented. Different building blocks are discussed which are used in the cell. A chip has been made with 16 by 16 cells with additional circuitry to accomplish the whole structure of the CNN Universal Machine. Different measurement issues are also discussed.
Video shot segmentation and classification (2002)

We propose a technique for video shot segmentation and classification based on singular value decomposition (SVD). For the input video sequence, we create a feature-frame matrix A, and perform the SVD on it. From this SVD, we are able to not only derive the refined feature space to better segment the video sequence along the time axis, but also define metrics to enable classifications of the detected video shots. Using these SVD properties, we achieve the two goals of accurate video shot segmentation, and visual content-based shot classification at the same time.
Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets (2015)

Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8(+) T cells. There is strong in vivo evidence that the mouse XCR1(+) DCs subset acts as a key player in this process. The intracellular processes underlying cross-presentation remain controversial and several pathways have been proposed. Indeed, a wide number of studies have addressed the cellular process of cross-presentation in vitro using a variety of sources of antigen and antigen-presenting cells. Here, we review the in vivo and in vitro evidence supporting the current mechanistic models and disscuss their physiological relevance to the cross-presentation of cell-associated antigens by DCs subsets.
Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation (2004)

Folate deficiency induces neurotoxicity by multiple routes, including increasing cytosolic calcium and oxidative stress via increasing levels of the neurotoxin homocysteine (HC), and inducing mitochondrial and DNA damage. Because some of these neurotoxic effects overlap with those observed in motor neuron disease, we examined the impact of folate deprivation on dorsal root ganglion (DRG) neurons in culture. Folate deprivation for 2 h increased cytosolic calcium and reactive oxygen species (ROS) and impaired mitochondrial function. Treatment with nimodipine [an L voltage-sensitive calcium channel (LVSCC) antagonist], MK-801 (an NMDA channel antagonist) and thapsigarin (an inhibitor of efflux of calcium from internal stores) indicated that folate deprivation initially induced calcium influx via the LVSCC, with subsequent additional calcium derived from NMDA channels and internal stores. These compounds also reduced ROS and mitochondrial degeneration, indicating that calcium influx contributed to these phenomena. Calcium influx was prevented by co-treatment with 3-deaza-adenosine, which inhibits HC formation, indicating that HC mediated increased cytosolic calcium following folate deprivation. Nimodipine, MK-801 and thapsigargin had similar effects following direct treatment with HC as they did following folate deprivation. These findings support the idea that folate deprivation and HC treatment can compromise the health of DRG neurons by perturbing calcium homeostasis.
Niruriside, a New HIV REV/RRE Binding Inhibitor from <i>Phyllanthus niruri</i> (1996)

During the screening of natural products for their ability to inhibit the binding of HIV-REV protein to [33P]-labeled RRE RNA, one novel compound, niruriside (1), was isolated from the MeOH extract of the dried leaf of Phyllanthus niruri L. by bioassay-guided fractionation. The structure of niruriside was determined by spectroscopic methods. Niruriside showed specific inhibitory activity against the binding of REV protein to RRE RNA with an IC50 value of 3.3 microM; however, niruriside did not protect CEM-SS cells from acute HIV infection at concentrations up to 260 microM using an XTT dye reduction assay.
Preparation and properties of polyurethane networks based on α,ω‐difunctional poly(hexafluoropropylene oxide) (1995)

Abstract Poly(hexafluoropropylene oxide), poly(HFPO), networks were prepared from functional polymers by end linking via urethane groups. The prepolymers were characterized by NMR spectroscopy and GPC. The networks were characterized by determination of the number of network chains from the shear modulus, and were snown to contain both trifunctional crosslinks and difunctional links. The properties of the networks were investigated by a range of techniques. Compared with fully‐fluorinated networks formed via triazine cross‐links, investigated previously, the urethane‐linked networks were more readily prepared but were poorer elastomers, were less thermally stable, and were less resistant to swelling by common polar solvents. © 1995 John Wiley & Sons, Inc.
Optimal HVAC building control with occupancy prediction (2014)

Buildings account for about 41% of primary energy consumption and 75% of the electricity. Space heating, space cooling, and ventilation are the dominant end uses, accounting for 41% of all energy consumed in the buildings sector. Growing interest in sustainability has resulted in research efforts to reduce energy consumption while providing adequate comfort to users.
Ethanol Inhibits Lung Clearance of<i>Pseudomonas aeruginosa</i>by a Neutrophil and Nitric Oxide‐Dependent Mechanism, In Vivo (1999)

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen that can be found in individuals in which the immune system has been suppressed by HIV/AIDS or chronic alcoholism. We evaluated the role of inducible nitric oxide synthase (NOS II) as a modulator of lung concentrations of P. aeruginosa in normal rats and rats given a single dose of ethanol (ETOH). Rats were pretreated with either sterile saline (PBS, 0.1 ml/kg, i.v.) or the NOS II inhibitor L-N6-iminoethyl lysine (LNIL, 10 mg/kg, i.v.) 15 min before intraperitoneal administration of either PBS (4.5 ml/kg) or ETOH (4.5 g/kg). Thirty min after administration of PBS or ETOH the rats were placed in inhalation chambers and exposed to 45 min of an aerosol containing P. aeruginosa (5 x 10(4) colony forming units, CFU). A group of rats (n = 5-6/treatment/time period) were killed immediately (0 hr) or 4 hr after inhalation of P. aeruginosa. The lungs were homogenized and the P. aeruginosa were grown in nutrient broth to determine the number of viable CFU remaining in the lung. The NOS II and TNFalpha mRNA and protein content lung alveolar macrophages (AM) and neutrophils (PMN) were measured with RT-PCR and Western blot. The concentration of nitrate and nitrite anion in the bronchoalveolar lavage fluid (BALf) and ex vivo incubates of PMN were also measured. The CFU of P. aeruginosa present in the lungs of the four groups of rats at 0 hr did not differ. The CFU of P. aeruginosa in the lung increased (p < 0.05) in rats pretreated with ETOH when compared with that obtained from rats pretreated with PBS. However, pretreatment of rats with LNIL decreased (p < 0.05) the 4 hr lung content of P. aeruginosa. Coadministration of LNIL and ETOH to rats augmented the CFU of P. aeruginosa in lungs to amounts which did not differ from that of rats pretreated with ETOH. Inhalation of P. aeruginosa increased NOS II mRNA and protein in rat AM and PMN. Pretreatment of rats with ETOH alone, or in combination with LNIL, inhibited P. aeruginosa-induced NOS II transcription and translation and AM and PMN nitrate and nitrite generation whereas pretreatment with LNIL alone only inhibited nitrate and nitrite generation. Pretreatment of rats with ETOH suppressed P. aeruginosa stimulated PMN recruitment into the lung whereas LNIL enhanced (p < 0.05) P. aeruginosa-stimulated PMN recruitment into the lung. ETOH-induced increases of the lung content of P. aeruginosa were associated with increased PKC delta isozyme in the membrane of the PMN but could not be explained by altered plasma concentrations of hydrocortisone or ETOH. The data demonstrate that selective inhibition of NOS II-derived NO by LNIL decreases the lung content of P. aeruginosa whereas ETOH inhibits the lung clearance of P. aeruginosa. Speculatively, the difference between these effects of LNIL and ETOH may result from differences in drug-induced changes in lung recruitment of PMN.
Resistance to Lettuce Aphid (Nasonovia ribisnigri) Biotype 0 in Wild Lettuce Accessions PI 491093 and PI 274378 (2012)

The lettuce aphid, Nasonovia ribisnigri Mosley (Hemiptera: Aphididae), is a major insect pest of lettuce, Lactuca sativa L, in many commercial lettuce production areas around the world. Resistance to lettuce aphid biotype 0 (Nr:0) was first reported in Lactuca virosa L. accession IVT 280 and characterized as complete, i.e., virtually no aphids survived, and genetically dominant to partial resistance in L. virosa accession IVT 273. Complete and partial resistances to Nr:0 were conditioned by two alleles, Nr (complete resistance) and nr (partial resistance), but the genetic relationship to susceptibility was not reported. We previously reported two new potential sources of unique genes for resistance to Nr:0 in Lactuca serriola L. accession PI 491093 and L. virosa PI 274378. We report on the genetic and phenotypic nature of resistance to Nr:0 in these two wild lettuce accessions. Resistance to Nr:0 in PI 274378 is complete and allelic to complete resistance in IVT 280. Resistance to Nr:0 in PI 491093 was partial, recessive to complete resistance in ‘Barcelona’ that was derived from IVT 280, but dominant to susceptibility in ‘Salinas’. We propose the revised gene symbols for resistance to Nr:0: Nr:0 C for complete resistance and Nr:0 P for partial resistance, which was originally designated as nr but may now be regarded as the symbol for susceptibility to all strains of lettuce aphid. The dominance relationships among these three alleles are Nr:0 C (in IVT 280, ‘Barcelona’) > Nr:0 P (in PI 491093) > nr (in susceptible genotypes). Expression of partial resistance in PI 491093 was variable in controlled infestation tests, but in a naturally infested field test provided a potentially useful level of resistance to Nr:0. Partial resistance, where complete resistance has not been widely deployed, may either alone or as a component of integrated pest management delay or prevent emergence of genotypes that overcome complete resistance controlled by Nr:0 C .