gebhart/patrepeval huggingface dataset:
A menu-driven, touch panel microcomputer for clinical recordkeeping. (1981)

Quikchart is a menu-driven, touch-panel input microcomputer system designed for computer-naive physicians active in clinical environments. It enables them to generate patient encounter records, and to store and access them using electronic memory. It also permits printing hard-copy records. The system is designed so that the physician can do all this without resorting to a standard typewriter or computer keyboard. It circumvents the disadvantages of both handwritten records and dictated records. Upward expansion of Quikchart will allow individual systems to be networked into a clinic-wide medical record system.
Mastocytosis (2008)

This chapter contains sections titled: Pathology Mast cell biology Epidemiology Classification Clinical symptoms Diagnosis and diagnostic criteria for systemic mastocytosis Laboratory investigation Differential diagnosis Treatment Pediatric mastocytosis Acknowledgments References
Neuropsychological rehabilitation in the treatment of schizophrenia. (1997)

The Schizophrenia Rehabilitation Center at the Institute of Living has begun to develop rehabilitation techniques based on a neuropsychological approach to ameliorate the cognitive deficits associated with schizophrenia. A study was designed to test the hypothesis that patients receiving attention skills training would demonstrate improved performance on neuropsychological tests measuring concentration. Five out of the seven subjects significantly improved on more than half of the neuropsychological measures. In the two case studies reviewed, significant increases in test scores were observed more frequently during cognitive rehabilitation then when psychoeducation classes were substituted for the attention skills training. In addition, patients showed improvement on the Positive and Negative Syndrome Scale and Quality of Life Scale. The data support the efficacy of attention skills training using a process specific approach. However, it is uncertain if attention skills rehabilitation is a necessary or sufficient factor in producing the therapeutic change.
Superinduction of c- <i>fos</i> by Nerve Growth Factor in the Presence of Peripherally Active Benzodiazepines (1985)

Alterations in proto-oncogene expression after stimulation of rat pheochromocytoma (PC12) cells by nerve growth factor (NGF) have been investigated. A specific stimulation of c-fos messenger RNA and protein was detected 30 minutes after treatment. This induction was enhanced more than 100-fold in the presence of peripherally active benzodiazepines. The effect was specific as very little change was observed in the levels of c-rasHa, c-rasKi, c-myc, and N-myc messenger RNA's. Under the conditions used here, NGF treatment ultimately results in neurite outgrowth, with a reduction or cessation of cell division. Thus, stimulation of the c-fos gene in this system appeared to be associated with differentiation and not with cellular proliferation. The effect of benzodiazepines was stereospecific and represents a novel action of these compounds at the level of gene expression.
The arms and insignia of the mexica (1972)

This study provides a detailed analysis of the arms and insignia used by the Mexica, emphasizing their role in shaping their vast empire. It highlights that these objects were mainly made from perishable materials such as wood, leather, and feathers, explaining their scarce physical preservation. Drawing on sources like the Códice Matritense, it offers descriptions and illustrations that enrich the cultural understanding of Nahua weaponry and emblems. Technical and symbolic aspects are also emphasized, including the protection offered by the ichcahuipilli and the intimidating appearance produced by ornamental accessories. The work significantly contributes to the study of the Mexica's armament and social history
Multimodal bioimaging using a rare earth doped Gd2O2S:Yb/Er phosphor with upconversion luminescence and magnetic resonance properties (2013)

While infrared upconversion imaging using halide nanoparticles are so common the search for a very efficient halide free upconverting phosphors is still lacking. In this article we report Gd<sub>2</sub>O<sub>2</sub>S:Yb/Er,YbHo,YbTm systems as a very efficient alternative phosphors that show upconversion efficiency comparable or even higher than existing halide phosphors. While the majority of rare earth dopants provide the necessary features for optical imaging, the paramagnetic Gd ion also contributes to the magnetic imaging,thereby resulting in a system with bimodal imaging features. Results from imaging of the nanoparticles together with aggregates of cultured cells have suggested that imaging of the particles in living animals may be possible. <i>In vitro</i> tests revealed no signficant toxicity because no cell death was observed when the nanoparticles were in the presence of growing cells in culture. Measurement of the magnetization of the phosphor shows that the particles are strongly magnetic, thus making them suitable as an MRI agent.
USE OF APATITE FOR CHEMICAL STABILIZATION OF SUBSURFACE CONTAMINANTS (2003)

Groundwater at many Federal and civilian industrial sites is often contaminated with toxic metals at levels that present a potential concern to regulatory agencies. The U.S. Department of Energy (DOE) has some unique problems associated with radionuclides (primarily uranium), but metal contaminants most likely drive risk-based cleanup decisions, from the perspective of human health, in groundwater at DOE and U.S. Environmental Protection Agency (EPA) Superfund Sites include lead (Pb), arsenic (As), cadmium (Cd), chromium (Cr), mercury (Hg), zinc (Zn), selenium (Se), antimony (Sb), copper (Cu) and nickel (Ni). Thus, the regulatory ''drivers'' for toxic metals in contaminated soils/groundwaters are very comparable for Federal and civilian industrial sites, and most sites have more than one metal above regulatory action limits. Thus improving the performance of remedial technologies for metal-contaminated groundwater will have ''dual use'' (Federal and civilian) benefit.
Developing a workstation for stocktraders (1999)

The Russian Trading System Technical Centre (RTS TC) was founded in October 1995 as a technical support centre to operate the RTS. Its main objective is to provide financial markets operators with technological tools to perform trading, manage front office and back office activities, organize the transmission of the data between the trading system, broker-dealer firms, clearing and settlement institutions, control authorities and to the public. The article describes the system and in particular its user interface-the information provided, its layout, the style of interaction, communication methods, and alerts.
Electrode Materials for Lithium Ion Battery (2011)

It has been 20 years since lithium ion battery appeared as a commercial product.Different kinds of new electrode materials are urgently needed to meet the demands of the society.In this review,some knowledge about lithium ion battery is first given.Then we focus on several new positive /negative electrode materials reported up to date.When they were used as lithium ion battery electrode materials,how they are synthesized,the main improvement methods and their electrochemical performance will be presented.Finally,we give a short summary of the advantages /disadvantages of these new electrode materials.Furthermore,an outlook for the potential applications of lithium ion batteries in the future is proposed.
Trend Data On Medical Encounters: Tracking A Moving Target (2001)

The National Health Care Survey (NHCS), conducted by the National Center for Health Statistics, consists of separate data collection activities that can be used to track the number and content of health care encounters in the United States. Tracking even something as simple as the number of encounters, however, is complicated by the fact that the content of these encounters changes over time. Results from the NHCS indicate that the U.S. population has been receiving more drugs, more cardiac procedures, more ambulatory surgery, more therapies in nursing homes, and more home health care over time. Policymakers and researchers who examine health care trends should be wary about judging whether the number of length of encounters is positive or negative without also examining the content of these encounters.
Noninvasive stress recognition considering the current activity (2015)

In this study, we aim to determine the stress level in a non-invasive way to the maximum extent possible by analyzing behavioral and contextual data received from the only source being a smartphone containing the data gathered in real-life situations. The information collected includes audio, gyroscope and accelerometer features, light condition, screen mode (on/off), current stress level self-assessment, and the current activity type. Three stress analysis models have been built: two with the consideration of current activities of a participant and one without those. Classification of low- and high-stress conditions, which was executed for a separate model for a certain kind of activity only, enabled us to achieve 3.9 % higher accuracy than that under the conditions when those activities were neglected. Also, the Android application was developed as a means for the current activity-type identification.
Unexpected A-form formation of 4′-thioDNA in solution, revealed by NMR, and the implications as to the mechanism of nuclease resistance (2008)

Fully modified 4'-thioDNA, an oligonucleotide only comprising 2'-deoxy-4'-thionucleosides, exhibited resistance to an endonuclease, in addition to preferable hybridization with RNA. Therefore, 4'-thioDNA is promising for application as a functional oligonucleotide. Fully modified 4'-thioDNA was found to behave like an RNA molecule, but no details of its structure beyond the results of circular dichroism analysis are available. Here, we have determined the structure of fully modified 4'-thioDNA with the sequence of d(CGCGAATTCGCG) by NMR. Most sugars take on the C3'-endo conformation. The major groove is narrow and deep, while the minor groove is wide and shallow. Thus, fully modified 4'-thioDNA takes on the A-form characteristic of RNA, both locally and globally. The only structure reported for 4'-thioDNA showed that partially modified 4'-thioDNA that contained some 2'-deoxy-4'-thionucleosides took on the B-form in the crystalline form. We have determined the structure of 4'-thioDNA in solution for the first time, and demonstrated unexpected differences between the two structures. The origin of the formation of the A-form is discussed. The remarkable biochemical properties reported for fully modified 4'-thioDNA, including nuclease-resistance, are rationalized in the light of the elucidated structure.
α-DNA IX: parallel annealing of α-anomeric oligodeoxyribonucleotides to natural mRNA is required for interference in RNase H mediated hydrolysis and reverse transcription (1989)

ps- and aps-alpha anomeric oligodeoxyribonucleotides were designed to recognize in parallel (ps) or antiparallel (aps) orientation two different sites of a 1000 base-long mRNA. Northern blots experiments indicate that only ps-alpha-oligonucleotides were able to hybridize to the mRNA target. Furthermore, only ps-alpha-oligonucleotides were able, in a sequence specific way, to protect the mRNA target against RNase H mediated hydrolysis or to inactivate the priming capacity of beta-oligodeoxynucleotide probes in reverse transcription. Formation of parallel-stranded mRNA alpha-oligonucleotide miniduplexes which prevents hybridization of beta-oligonucleotide probes is the most likely mechanism accounting for these results. Use of alpha-oligonucleotides as potential gene control agents is discussed.
Editorial Vol. 10 N. 2 (2015) (2015)

survey entre projetistas e construtores para melhor compreender de que forma esses profissionais avaliam os processos de projeto e os produtos imobiliários deles decorrentes, identificando os aspectos apontados como insatisfatórios.Discutem em especial o ponto de vista dos profissionais diante dos desafios de se implementar o Building Information Modeling (BIM) tendo como
Acoustic differential delay and Doppler tracking system for long range AUV positioning and guidance (2002)

An acoustic positioning and guidance technique, based upon differential delay and Doppler tracking system, is proposed for long distance 2D navigation and path planning on board autonomous underwater vehicles (AUVs). This system is also easily extendable to short distance 3D positioning and guidance with the use of a bottom echo sounder on board the AUV. For positioning purpose, the system uses a single low-cost omnidirectional hydrophone mounted on the AUV, and is associated to an external (fixed or towed) dual frequency transmitting subsystem. This technique can be viewed as a combined version of the classical long base (delay) and short base (phase) trajectography. For path planning and AUV guidance, the predicted mute is described as a sequence of iso-differential delay and/or iso-differential Doppler segments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Noninvasive Bed Sensing of Human Biosignals Via Piezoceramic Devices Sandwiched Between the Floor and Bed (2010)

This paper describes a novel bed sensing method for noninvasive, constraint-free, subliminal detection of biosignals. The sensor system detects the heartbeat, respiration, body movement, position change, and scratching motion of a person lying or sleeping on the bed. These biosignals provide not only basic medical information but also sophisticated details about sleep conditions. Thus, the bed sensing method can be used to monitor the health condition of people sleeping at home, as well as that of patients in the hospital. Furthermore, the bed sensor system can detect emerging changes in the physical condition of a person, whether at home or in the hospital. The basic device used for sensing is piezoceramic bonded to stainless steel plate sandwiched between the floor and the four corners of the bed. Thus, no special bed is required. The device, which detects the biosignals generated as mechanical vibrations, has a wide dynamic range and high signal-to-noise (SN) ratio enabling the detection of microvibrations from the heartbeat by the change in acting force, without saturation from body movements. It accurately detects the person's heartbeat and respiration as well as body movement and even the number of scratching motions. The device is suitable for various health monitoring applications including sleep and medical monitoring for circulatory system disorders, as well as diseases characterized by itching.
Higher order FM mode locking for pulse-repetition-rate enhancement in actively mode-locked lasers: theory and experiment (1999)

We present a novel higher order FM mode-locked technique for active mode-locked lasers which utilizes the higher order sidebands generated by an intracavity phase modulator to establish the mode locking. The resulting mode-locked output exhibits an enhancement of the pulse repetition rate over the modulation frequency by an integral multiple. The higher order FM mode locking is studied theoretically in a laser with a homogeneous gain medium, and simple analytical expressions are obtained to characterize the output pulses. It is shown that the scheme not only enhances the pulse repetition rate but also ensures chirp-free pulses and is effective in eliminating the output pulse phase-state instability, which are commonly observed in conventional FM mode-locked lasers. The effect of group velocity dispersion and cavity nonlinearity is also investigated through numerical solution of the self-consistency equation applied to a fiber ring laser. Finally, detailed experimental results on repetition rate enhancement in fiber lasers are presented and shown to be in good agreement with the theoretical results.
Aberrant hormone receptors in adrenal Cushing's syndrome (2002)

The mechanisms of production of cortisol in adrenal Cushing's syndrome, in which corticotropin is suppressed, were previously unknown and believed to be autonomous. Increasing evidence indicates that adrenocortical steroidogenesis may be mediated by hormones other than corticotropin because of the aberrant (or ectopic, illicit) expression and function of their membrane receptors in the adrenal tumors. To date, ectopic receptors for gastric inhibitory polypeptide, β-adrenergic agonists, luteinizing hormone/human chorionic gonadotropin, and probably angiotensin II type 1 (AT-1) have been identified; altered activity of eutopic receptors such as those for vasopressin (V1-arginin-vasopressin receptor), serotonin (5-HT4R), and leptin may be involved. The identification of aberrant adrenal hormone receptors offers the potential for novel pharmacologic therapies by suppressing the endogenous ligands or by blocking the aberrant receptor with specific antagonists. Further studies may identify a larger diversity of hormone receptors capable of coupling to G-proteins, adenylyl cyclase, and steroidogenesis in adrenal tumors, and probably in other endocrine and nonendocrine tumors.
SCOPE-Seq: a scalable technology for linking live cell imaging and single-cell RNA sequencing (2018)

Optically decodable beads link the identity of a sample to a measurement through an optical barcode, enabling libraries of biomolecules to be captured on beads in solution and decoded by fluorescence. This approach has been foundational to microarray, sequencing, and flow-based expression profiling technologies. We combine microfluidics with optically decodable beads and show that phenotypic analysis of living cells can be linked to single-cell sequencing. As a proof-of-concept, we demonstrate the accuracy and scalability of our tool called Single Cell Optical Phenotyping and Expression sequencing (SCOPE-Seq) to combine live cell imaging with single-cell RNA sequencing.
Protein Composition of the Outer Membrane of <i>Salmonella typhimurium</i> : Effect of Lipopolysaccharide Mutations (1974)

The protein composition of the outer membrane of Salmonella typhimurium has been analyzed by electrophoresis on slabs of sodium dodecyl sulfate-acrylamide gel. This powerful technique allows very high resolution of protein mixtures and has permitted the identification of multiple major protein components of the outer membrane; no evidence for a single major component of molecular weight 44,000 was obtained. These proteins were shown to be decreased in amount in mutants which have defective lipopolysaccharides. Mutants of an apparently new type were also found which contain decreased amounts of the proteins and the parent-like lipopolysaccharide, yet are resistant to a lipopolysaccharide-specific phage, C21. Several outer membrane proteins are insoluble in sodium dodecyl sulfate unless heated at high temperature (above 70 C). A purification procedure based on this property is tentatively suggested.
Platinum-Decorated Nanoporous Gold Leaf for Methanol Electrooxidation (2007)

Pt-decorated nanoporous gold (Pt-NPG) leaf was prepared by depositing an atomically thin layer of Pt over NPG substrate where Pt overlayers grow epitaxially on NPG surfaces. Their catalytic properties toward methanol and CO electrooxidation were studied, and they show structure-sensitive activities and a greatly enhanced antipoisoning effect.
X-ray powder diffraction analysis of a nonlinear optical material 1-benzoyl-3-(4-benzyl)thiourea [ <i>N</i> - <i>benzoyl</i> - <i>N</i> <sup>′</sup> -(4- <i>benzyl</i> ) <i>thiourea</i> ] (1998)

A nonlinear optical material, 1-benzoyl-3-(4-benzyl)thiourea ( C 15 H 14 N 2 OS ), has been characterized by X-ray powder diffraction. Experimental values of 2θ corrected for systematic errors, relative peak intensities, values of d , and the Miller indices of 82 observed reflections with 2θ up to 80° are reported. The powder diffraction data have been evaluated, and the figures-of-merit are reported. The least-squares refined unit cell parameters are a =22.0243(6)Å, b =10.9795(7)Å, c =13.0322(8)Å, β=116.88(2)°, V =2810.8(9)Å 3 , Z =8, Dx =1.278 g / cm 3 , space group Pn .
Non-Responders to Cardiac Resynchronization Therapy - The Magnitude of the Problem and the Issues - (2011)

A variable proportion of cardiac resynchronization therapy (CRT) patients do not benefit from treatment (termed `non-responders'). The problem of non-response to CRT might become increasingly important, because it is anticipated that larger groups of heart failure patients are indicated to the therapy. This article will discuss the definition of response to CRT, the parameters related to response to CRT, and finally whether response to CRT might be predicted. The effort to improve patient selection in order to maximize human and financial resource utilization has fallen short so far. It is, however, conceivable that rather than the identification of a `universally' applicable cut-off value, risk strata-in which inclusion of method for determination of left ventricular volumes, etiology, QRS duration and morphology, etc-might better serve the goal of defining non-responders. Potentially simple clinical scores might help in refining outcome and by doing so, allow to more precisely measure response to CRT in daily practice in the individual patient at the time of CRT implantation. Although sophisticated cardiac imaging modalities have been intensively utilized for improving patient outcome, it seems that many mechanical dyssynchrony measures suffer from technical limitations and from difficult interpretation of the complex signals, which lack reproducibility outside highly specialized laboratories.
ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function (2016)

Mutations in FUS cause amyotrophic lateral sclerosis (ALS), including some of the most aggressive, juvenile-onset forms of the disease. FUS loss-of-function and toxic gain-of-function mechanisms have been proposed to explain how mutant FUS leads to motor neuron degeneration, but neither has been firmly established in the pathogenesis of ALS. Here we characterize a series of transgenic FUS mouse lines that manifest progressive, mutant-dependent motor neuron degeneration preceded by early, structural and functional abnormalities at the neuromuscular junction. A novel, conditional FUS knockout mutant reveals that postnatal elimination of FUS has no effect on motor neuron survival or function. Moreover, endogenous FUS does not contribute to the onset of the ALS phenotype induced by mutant FUS. These findings demonstrate that FUS-dependent motor degeneration is not due to loss of FUS function, but to the gain of toxic properties conferred by ALS mutations.