gebhart/patrepeval huggingface dataset:
Therapeutic benefit of mesenchymal stem cells in pregnant rats with angiotensin receptor agonistic autoantibody-induced hypertension: Implications for immunomodulation and cytoprotection (2017)

Immunomodulation by mesenchymal stem cells (MSCs) is potentially important for maintaining peripheral tolerance. Preeclampsia may be due to maternal immune rejection of the genetically foreign fetus. This study aimed to investigate the biological function of human umbilical cord-derived mesenchymal stem cells (HU-MSCs) for the treatment of angiotensin receptor agonistic autoantibody (AT1-AA)-induced hypertension during pregnancy. HU-MSCs were isolated, cultured, and labeled in vitro. AT1-AA and HU-MSCs were administered to pregnant rats. Green fluorescent protein (GFP)-positive HU-MSCs infused in vivo were identified by immunofluorescence. Systolic blood pressure (SBP) was evaluated. The effects of HU-MSCs on fetal weight, kidney burden, and spiral artery remodeling, as well as on the expression of tumor necrosis factor α (TNF-α), interleukin 10 (IL-10), and heme oxygenase 1 (HO-1), were investigated. The SBP levels in the HU-MSC-treated pregnant hypertension rats decreased by gestational day 19. The reduction in fetal weight was largely ameliorated after HU-MSC treatment. Lesion burden in the kidney was attenuated and spiral artery remodeling was improved in HU-MSC-treated pregnant hypertension rats. However, green fluorescent protein (GFP)-labeled cells were sparingly observed in the kidney and placenta. Intravenous infusion of HU-MSCs into AT1-AA-induced rats significantly downregulated serum TNF-α levels and upregulated IL-10 levels, concomitant with increased placenta and mesometrial triangle (MT) HO-1 expression. Taken together, intravenous infusion of HU-MSCs ameliorates AT1-AA-induced pregnancy hypertension, intrauterine growth retardation, kidney impairment, and spiral artery remodeling impairment. Moreover, the potential benefits of HU-MSCs may be attributable to both an interference with the pathogenic immune response and a paracrine cytoprotective action.
Hepatic Hemorrhage Caused by Percutaneous Tumor Ablation: Radiofrequency Ablation versus Cryoablation in a Porcine Model (2005)

Mean blood loss from percutaneous cryoablation in this model was between that for RF ablation with the single electrode and that for RF ablation with the electrode cluster.
249. Mechanism of substitution at a saturated carbon atom. Part VIII. Hydrolysis of tert.-butyl halides (1937)

K. A. Cooper and E. D. Hughes, J. Chem. Soc., 1937, 1183 DOI: 10.1039/JR9370001183
Combination of Functional Nanoengineering and Nanosecond Laser Texturing for Design of Superhydrophobic Aluminum Alloy with Exceptional Mechanical and Chemical Properties (2017)

Industrial application of metallic materials is hindered by several shortcomings, such as proneness to corrosion, erosion under abrasive loads, damage due to poor cold resistance, or weak resistance to thermal shock stresses, etc. In this study, using the aluminum-magnesium alloy as an example of widely spread metallic materials, we show that a combination of functional nanoengineering and nanosecond laser texturing with the appropriate treatment regimes can be successfully used to transform a metal into a superhydrophobic material with exceptional mechanical and chemical properties. It is demonstrated that laser chemical processing of the surface may be simultaneously used to impart multimodal roughness and to modify the composition and physicochemical properties of a thick surface layer of the substrate itself. Such integration of topographical and physicochemical modification leads to specific surface nanostructures such as nanocavities filled with hydrophobic agent and hard oxynitride nanoinclusions. The combination of superhydrophobic state, nano- and micro features of the hierarchical surface, and the appropriate composition of the surface textured layer allowed us to provide the surface with the outstanding level of resistance of superhydrophobic coatings to external chemical and mechanical impacts. In particular, experimental data presented in this study indicate high resistance of the fabricated coatings to pitting corrosion, superheated water vapor, sand abrasive wear, and rapid temperature cycling from liquid nitrogen to room temperatures, without notable degradation of superhydrophobic performance.
Self-aligned InGaP/GaAs heterojunction bipolar transistors for microwave power application (1993)

As an alternative to AlGaAs/GaAs heterojunction bipolar transistors (HBTs) for microwave applications, InGaP/GaAs HBTs with carbon-doped base layers grown by metal organic molecular beam epitaxy (MOMBE) with excellent DC, RF, and microwave performance are demonstrated. As previously reported, with a 700-AA-thick base layer (135- Omega /sq sheet resistance), a DC current gain of 25, and cutoff frequency and maximum frequency of oscillation above 70 GHz were measured for a 2- mu m*5- mu m emitter area device. A device with 12 cells, each consisting of a 2- mu m*15- mu m emitter area device for a total emitter area of 360 mu m/sup 2/, was power tested at 4 GHz under continuous-wave (CW) bias condition. The device delivered 0.6-W output power with 13-dB linear gain and a power-added efficiency of 50%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Commentary: Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group (2013)

During the summer of 2012, in Jeddah, Saudi Arabia, a hitherto unknown coronavirus (CoV) was isolated from the sputum of a patient with acute pneumonia and renal failure (1, 2). The isolate was provisionally called human coronavirus Erasmus Medical Center (EMC) (3). Shortly thereafter, in September 2012, the same type of virus, named human coronavirus England 1, was recovered from a patient with severe respiratory illness who had been transferred from the Gulf region of the Middle East to London, United Kingdom (4) (GenBank accession no. KC164505.2). The onset of the new disease was traced back to an even earlier time point. Already in April 2012, a cluster of pneumonia cases in health care workers had occurred in an intensive care unit of a hospital in Zarqa, Jordan (5). Two persons died, both of whom were confirmed to have been infected with the novel coronavirus through a retrospective analysis of stored samples (6). These findings met with considerable concern. Although the number of laboratory-confirmed cases is limited (34 as of 12 May 2013), the morbidity and mortality of the infection is alarming, as is its uncanny resemblance—at least in its clinical features—to severe acute respiratory syndrome (SARS). While in a small minority of the known cases the patients developed mild disease, most patients presented with a severe acute respiratory condition requiring hospitalization; the mortality rate is approximately 60% (7).
Teaching code review management using branch based workflows (2016)

Developing software with high code quality in a university environment is a challenge for instructors of software engineering capstone courses. Teaching students how to achieve quality and how to conduct code reviews in projects is often neglected, although it helps to improve maintainability.
Multipath Extensions for QUIC (MP-QUIC) (2020)

This document specifies extensions to the QUIC protocol to enable the
simultaneous usage of multiple paths for a single connection. The
proposed extensions remain compliant with the current single-path QUIC
design and preserve the QUIC privacy features.
Subtype-specific expression and genetic alterations of the chemokinereceptor geneCXCR4 in medulloblastomas (2005)

Recent findings indicate that the chemokine receptor Cxcr4 is essential for normal development of the cerebellar cortex. As medulloblastomas (MBs), the most common malignant brain tumors of childhood, are believed to arise from neuronal cerebellar precursors, we asked whether there is a potential role for Cxcr4 in the pathogenesis of MB. RT-PCR and immunohistochemistry revealed expression of Cxcr4 in different variants of MBs. Whereas 18/20 classic MBs showed very low levels of CXCR4 mRNA, high amounts were expressed in 17/18 desmoplastic and 6/7 extensively nodular MBs. In addition, a significant correlation of high CXCR4 mRNA levels and presence of the neurotrophin receptor p75NTR or expression of ATOH1 and GLI1 suggests that CXCR4 is a reliable marker for tumors derived from the cerebellar external granular layer. Because Cxcr4 is important for migration and cell cycle control of granular precursors, we screened for mutations in the coding region by SSCP and gene sequencing. In a series of 90 MBs and 8 MB cell lines, we found one germline and one somatic mutation resulting in amino acid substitutions in the first (Ile53Leu) and second (Asp97Asn) transmembrane regions, respectively. These data suggest that Cxcr4 may be involved in the pathogenesis of MBs.
Increased prevalence of septal cavitation in a nonschizophrenic sample: an MRI study of HIV-infected individuals (1996)

Analyses of MRI scans of 26 asymptomatic HIV-infected individuals (HIV+) and 10 HIV-seronegative psychiatric control subjects (HIV-) revealed an incidental finding: 50% of the HIV+ subjects had discernible cleft in the septum pellucidum (cavum septi pellucidi; CSP), compared to only 20% of the HIV- control subjects. HIV+ subjects with CSP were more likely to complain of sensory changes and performed more poorly on specific neuropsychological tests when compared with HIV+ subjects without CSP. These findings suggest that elevated rates of CSP are not limited to the schizophrenic population. CSP may be a marker of premorbid events that increase the vulnerability to cognitive and perhaps behavioral sequelae of neurologic disease or injury.
Long-range, noncoherent lasers Doppler velocimeter (1991)

An experimental demonstration of a long-range, noncoherent laser Doppler velocimeter (LDV) is presented. The LDV detects incoming Doppler-shifted signal photons by using the sharp spectral absorption features in atomic or molecular vapors. The edge of the absorption feature is used to convert changes in frequency to large changes in transmission. Preliminary measurements of wind velocity using seeded aerosols showed that the LDV results agreed with mechanical anemometer measurements to within the accuracy of the LDV measurements. With optimization the LDV will provide accurate range-resolved and vibration-tolerant wind-speed measurements at large distances.
A Type System that Reconciles Classes and Extents (1991)

We present a type system that naturally couples two dierent, and apparently contradictory, notions of inheritance that occur in object-oriented databases. To do this we distinguish between the type and a kind of a value. A type describes the entire structure of a value, while a kind describes only the availability of certain elds or methods. This distinction allows us to manipulate heterogeneous collections (collections of values with diering types) in a statically type-checked language. Moreover, the type system is polymorphic and types may be inferred using an extension of the technique used in ML. This means that it is easy to express general-purpose operations for the manipulation of heterogeneous collections. We believe that this system not only provides a natural approach to static type-checking in object-oriented databases; it also oers a technique for dealing with external databases in a statically typed language. 1 Introduction The term \\inheritance&quot; is used in ...
The Parkinson's disease gene <i>PINK1</i> activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3 (2019)

Akt signalling is central to cell survival, metabolism, protein and lipid homeostasis, and is impaired in Parkinson's disease (PD). Akt activation is reduced in the brain in PD, and by many PD-causing genes, including <i>PINK1</i> This study investigated the mechanisms by which PINK1 regulates Akt signalling. Our results reveal for the first time that PINK1 constitutively activates Akt in a PINK1-kinase dependent manner in the absence of growth factors, and enhances Akt activation in normal growth medium. In PINK1-modified MEFs, agonist-induced Akt signalling failed in the absence of PINK1, due to PINK1 kinase-dependent increases in PI(3,4,5)P<sub>3</sub> at both plasma membrane and Golgi being significantly impaired. In the absence of PINK1, PI(3,4,5)P<sub>3</sub> levels did not increase in the Golgi, and there was significant Golgi fragmentation, a recognised characteristic of PD neuropathology. PINK1 kinase activity protected the Golgi from fragmentation in an Akt-dependent fashion. This study demonstrates a new role for PINK1 as a primary upstream activator of Akt via PINK1 kinase-dependent regulation of its primary activator PI(3,4,5)P<sub>3</sub>, providing novel mechanistic information on how loss of PINK1 impairs Akt signalling in PD.This article has an associated First Person interview with the first author of the paper.
A perspective on the selection of unrelated donors and cord blood units for transplantation (2012)

Selection of a suitable graft for allogeneic hematopoietic stem cell transplantation involves consideration of both donor and recipient characteristics. Of primary importance is sufficient donor-recipient HLA matching to ensure engraftment and acceptable rates of GVHD. In this Perspective, the National Marrow Donor Program and the Center for International Blood and Marrow Transplant Research provide guidelines, based on large studies correlating graft characteristics with clinical transplantation outcomes, on appropriate typing strategies and matching criteria for unrelated adult donor and cord blood graft selection.
Subtle atomic group discrimination in the RNA minor groove (1997)

As a problem in molecular recognition and for drug discovery, great interest has developed around the possibility that RNA structures could be discriminated by peptides and other small molecules. Although small peptides have been shown to have the capacity to discriminate specific bulges and loops in RNA molecules, discrimination of double helical regions by a peptide binder has not been reported. Indeed, the most accessible part of an RNA helix is the minor groove, and fundamental stereochemical considerations have suggested that discrimination of at least some base pairs would be difficult in the minor groove. Here we report the design and isolation of a peptide binder that manifests the most subtle kind of discrimination of base pair differences in the RNA minor groove. Functional discrimination of a single atomic group is demonstrated as well as the difference between two different angular orientations of the same group. This report of RNA helix discrimination by a peptide binder suggests a richer potential for RNA minor groove recognition than previously thought.
Effective Use of Dilated Convolutions for Segmenting Small Object Instances in Remote Sensing Imagery (2017)

Thanks to recent advances in CNNs, solid improvements have been made in semantic segmentation of high resolution remote sensing imagery. However, most of the previous works have not fully taken into account the specific difficulties that exist in remote sensing tasks. One of such difficulties is that objects are small and crowded in remote sensing imagery. To tackle with this challenging task we have proposed a novel architecture called local feature extraction (LFE) module attached on top of dilated front-end module. The LFE module is based on our findings that aggressively increasing dilation factors fails to aggregate local features due to sparsity of the kernel, and detrimental to small objects. The proposed LFE module solves this problem by aggregating local features with decreasing dilation factor. We tested our network on three remote sensing datasets and acquired remarkably good results for all datasets especially for small objects.
Mutagenesis, structure and function studies of thymidylate synthase. (1993)

The mechanism and structure of thymidylate synthase (TS) are fairly well understood. The function of amino acid residues of the enzyme have been studied by "replacement set mutagenesis" where multiple mutations at a given residue are produced and studied in detail. Some surprising results are (a) that there are few truly essential amino acids in TS, (b) that water may play an important role as a general acid/base catalyst, and (c) that a single mutation of Asn 229 to Asp changes specificity from a dUMP methylase to a dCMP methylase. Other mutagenesis and structure-function studies of interest will be discussed.
Apodizable integrated filters based on holographic Bragg reflectors (2004)

A dual-channel integrated multiplexer exhibiting flat-top 4-nm-wide passbands is demonstrated. The device is based on holographic Bragg reflectors (HBRs). Measured and designed device performance are in excellent agreement.
Validation of a Continuous Combined Heat and Power (CHP) Operation of a Two-Stage Biomass Gasifier (2006)

The Viking gasification plant at the Technical University of Denmark was built to demonstrate a continuous combined heat and power operation of a two-stage gasifier fueled with wood chips. The nominal input of the gasifier is 75 kW thermal. To validate the continuous operation of the plant, a 9-day measurement campaign was performed. The campaign verified a stable operation of the plant, and the energy balance resulted in an overall fuel to gas efficiency of 93% and a wood to electricity efficiency of 25%. Very low tar content in the producer gas was observed: only 0.1 mg/Nm3 naphthalene could be measured in raw gas. A stable engine operation on the producer gas was observed, and very low emissions of aldehydes, N2O, and polycyclic aromatic hydrocarbons were measured.
Feline lymphoid tissues engrafted into scid mice maintain morphologic structure and produce feline immunoglobulin. (1994)

To adapt the feline immune system to a small laboratory animal host, severe combined immunodeficient (scid) mice were engrafted with neonatal feline lymphoid tissues, including lymph node, thymus, spleen, and bone marrow. Lymph node and thymus tissue were implanted subcutaneously within the mammary fat pad, and a single-cell suspension of spleen, thymus, and bone marrow was inoculated intraperitoneally (IP). Seven groups of mice (three mice per group) were engrafted on day 0, and members of one group were euthanatized weekly from 2 to 8 weeks after engraftment. For each mouse, graft morphology was evaluated by light microscopy, feline DNA was detected in peripheral blood by polymerase chain reaction (PCR) amplification of feline-specific DNA sequences, and serum IgG concentration was measured by ELISA. Ten of 13 feline grafts evaluated histologically between 3 and 8 weeks after engraftment contained large focal aggregates of lymphocytes bordered by plasma cells. Of 14 thymus grafts evaluated histologically during the same period, 5 were characterized by dense accumulations of small lymphocytes surrounding thymic epithelial cells. Two of these thymus grafts were indistinguishable from age-matched feline thymus. At 2 weeks after engraftment, feline lymph node and thymus contained extensive central necrosis bordered by a narrow zone of lymphocytes and small-caliber blood vessels.(ABSTRACT TRUNCATED AT 250 WORDS)
Frequency and Inheritance of A and B Blood Types in Feline Breeds of the United States (1991)

Using a simple hemagglutination assay to determine A and B blood types, we surveyed 1,072 domestic short- and longhair (DSH/DLH) cats and 1,100 purebred cats in the United States. Data from 234 matings with 552 offspring were consistent with the hypothesis that feline blood types A and B are due to the action of two different alleles at the same gene locus and that A is completely dominant over B. Neither an AB nor an O type cat was encountered. No type B cats were found in the Siamese and related breeds or in American Shorthair and Norwegian Forest cats. Among the breeds with type B blood, the proportion was lowest in DSH/DLH cats (0.0028) and variably higher in Abyssinian, Birman, British Shorthair, Devon Rex, Himalayan, Persian, Scottish Fold, and Somali, ranging from 0.15 to 0.59. Since all type B cats have strong, naturally occurring anti-A alloantibodies, fatal neonatal isoerythrolyses occur in type A offspring of type B mothers bred to type A males. The gene frequency of the B allele and the proportion of mating at risk of neonatal isoerythrolysis were estimated in a number of breeds. In most breeds, the frequency of the B allele was less than 0.5. Since the kittens at risk for neonatal isoerythrolysis always have the genotype AB, there is constant natural selection against heterozygotes. Heterozygote disadvantage in the cat AB system represents an unusual form of negative selection, similar to that in Rh blood group incompatibility in humans.
Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis (1997)

tenance' enzymes that recognize and methylate hemi-methyl-
Silybin, a flavonolignan from milk thistle seeds, restrains the early and advanced glycation end product modification of albumin (2015)

Silybin exhibited a protective effect towards the non-enzymatic glycation mediated structure functional changes in albumin.
Efficient Virtual Machine Deployment in Large Scale Resource Environment (2010)

Combining virtual machine technology, virtual computing is able to effectively aggregate the widely distributed resources to provide users services. We view the federation of multiple data centers and voluntary resources on the Internet as a very large scale resource pool. Based on the tree structure of the pool, this paper proposes a virtual machine deployment algorithm, called iVDA, considers users' requests and the capabilities of the physical resources as well as the dynamic load, implements an adaptive mechanism to scheduling servers to host virtual machines forming virtual execution environments for various applications, and supports on-demand computing.
El acorde: naturaleza y definición (2013)

An atypical traffic accident scenario should be investigated directly at the crash site from all concerned professions, especially police men, forensic pathologists and technical experts, to get a personal overview and impression of the situation and the opportunity for interdisciplinary discussion. We present the rare case of a fatal traffic accident on a German motorway which was initially thought to be an accidental discovery of dumping a corpse. Based on autopsy findings, the technical investigation and the accident reconstruction, this case was solved as a spectacular form of a collision between a pedestrian and a bonnet-front car, which was not described elsewhere in scientific literature to the best of our knowledge. The pedestrian was hit in an upright body position, was lifted up by the car, smashed the windscreen and flew over the car with several body rotations. His flight curve ends directly at the roof of the car during brake processing, where the body touched the roof, smashed the rear-window and landed in the trunk. Based on the technical investigation, the driver of the car was not able to hide the accident. However, the pedestrian could have avoided the collision if he did not cross the motorway on foot.