gebhart/patrepeval huggingface dataset:
<i>MMS2</i> , encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway (1998)

Among the three Saccharomyces cerevisiae DNA repair epistasis groups, the RAD6 group is the most complicated and least characterized, primarily because it consists of two separate repair pathways: an error-free postreplication repair pathway, and a mutagenesis pathway. The rad6 and rad18 mutants are defective in both pathways, and the rev3 mutant affects only the mutagenesis pathway, but a yeast gene that is involved only in error-free postreplication repair has not been reported. We cloned the MMS2 gene from a yeast genomic library by functional complementation of the mms2-1 mutant [Prakash, L. & Prakash, S. (1977) Genetics 86, 33-55]. MMS2 encodes a 137-amino acid, 15.2-kDa protein with significant sequence homology to a conserved family of ubiquitin-conjugating (Ubc) proteins. However, Mms2 does not appear to possess Ubc activity. Genetic analyses indicate that the mms2 mutation is hypostatic to rad6 and rad18 but is synergistic with the rev3 mutation, and the mms2 mutant is proficient in UV-induced mutagenesis. These phenotypes are reminiscent of a pol30-46 mutant known to be impaired in postreplication repair. The mms2 mutant also displayed a REV3-dependent mutator phenotype, strongly suggesting that the MMS2 gene functions in the error-free postreplication repair pathway, parallel to the REV3 mutagenesis pathway. Furthermore, with respect to UV sensitivity, mms2 was found to be hypostatic to the rad6Delta1-9 mutation, which results in the absence of the first nine amino acids of Rad6. On the basis of these collective results, we propose that the mms2 null mutation and two other allele-specific mutations, rad6Delta1-9 and pol30-46, define the error-free mode of DNA postreplication repair, and that these mutations may enhance both spontaneous and DNA damage-induced mutagenesis.
A Year at the Movies in The People's Republic of China (2007)

Views and personal experiences of Chinese cinema-going in a town called Guangzhou are expressed. The movies screened are American commercial fare, screened one year later from their Western release date.
Electrowetting-Based Total Internal Reflection Chip for Optical Switch and Display (2006)

We present a novel electrowetting-based micro chip for optical switch and display. Electrowetting on dielectric layer (EWOD), using an electrode covered by an insulating film as the substrate for a conducting water drop, enables production of large and reversible contact angle variations, opening a wide field of applications in microphysics. Utilize the total internal reflection (TIR) occurs inside micro droplet, we can control the droplet curve by electrowetting to determinate light pass through or not The key advantage of this novel method is the ability to switch between the highly reflective and intensely colored states
Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model (2015)

Nicotinamide phosphoribosyltransferase (NAMPT) is a crucial enzyme in the biosynthesis of intracellular NAD+. NAMPT inhibitors have potent anticancer activity in several preclinical models by depleting NAD+ and ATP levels. Recently, we demonstrated that CD73 enables the utilization of extracellular NAD+/nicotinamide mononucleotide (NMN) by converting them to Nicotinamide riboside (NR), which can cross the plasmamembrane and fuel intracellular NAD+ biosynthesis in human cells. These processes are herein confirmed to also occur in a human ovarian carcinoma cell line (OVCAR-3), by means of CD73 or NRK1 specific silencing. Next, we investigated the anti-tumor activity of the simultaneous inhibition of NAMPT (with FK866) and CD73 (with α, β-methylene adenosine 5'-diphosphate, APCP), in an in vivo human ovarian carcinoma model. Interestingly, the combined therapy was found to significantly decrease intratumor NAD+, NMN and ATP levels, compared with single treatments. In addition, the concentration of these nucleotides in ascitic exudates was more remarkably reduced in animals treated with both FK866 and APCP compared with single treatments. Importantly, tumors treated with FK866 in combination with APCP contained a statistically significant lower proportion of Ki67 positive proliferating cells and a higher percentage of necrotic area. Finally, a slight but significant increase in animal survival in response to the combined therapy, compared to the single agents, could be demonstrated. Our results indicate that the pharmacological inhibition of CD73 enzymatic activity could be considered as a means to potentiate the anti-cancer effects of NAMPT inhibitors.
<title>Passive and active tagging of reinforced composites for in-process and in-field nondestructive evaluation</title> (1996)

Conventional non-destructive evaluation (NDE) methods are not very effective in monitoring the material conditions of advanced composite and adhesive joints. A technology that has been proposed to enhance the inspectability of advanced composites is the particle tagging technique. Two theoretical models were recently proposed to characterize the dynamic behavior of ferromagnetic and magnetostrictive tagging particles. These theoretical models concerning the development of an active tagging technique with embedded ferromagnetic and magnetostrictive particles and magnetic excitation are now experimentally verified. The experimental results of the active particle tagging shows a variation in the dynamic response of the specimens when defects and/or damage are present. The sensory signature from a tagged polymer is extracted as a result of the interaction between the embedded particles and their host matrix. A study of various types of composites and tagging particles for passive and active tagging was performed. Experimental validation of concepts for tagging of structural materials for on-site inspection prior to installation have also been explored. The on-site particle tagging inspection has been verified on laboratory specimens obtained from industry and was shown to be very efficient.
ADWISE: Adaptive Window-Based Streaming Edge Partitioning for High-Speed Graph Processing (2018)

In recent years, the graph partitioning problem gained importance as a mandatory preprocessing step for distributed graph processing on very large graphs. Existing graph partitioning algorithms minimize partitioning latency by assigning individual graph edges to partitions in a streaming manner - at the cost of reduced partitioning quality. However, we argue that the mere minimization of partitioning latency is not the optimal design choice in terms of minimizing total graph analysis latency, i.e., the sum of partitioning and processing latency. Instead, for complex and long-running graph processing algorithms that run on very large graphs, it is beneficial to invest more time into graph partitioning to reach a higher partitioning quality - which drastically reduces graph processing latency. In this paper, we propose ADWISE, a novel window-based streaming partitioning algorithm that increases the partitioning quality by always choosing the best edge from a set of edges for assignment to a partition. In doing so, ADWISE controls the partitioning latency by adapting the window size dynamically at run-time. Our evaluations show that ADWISE can reach the sweet spot between graph partitioning latency and graph processing latency, reducing the total latency of partitioning plus processing by up to 23-47 percent compared to the state-of-the-art.
Classification of solvents based on their coordination power to nickel(II) ion. A new measure for solvent donor ability (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTClassification of solvents based on their coordination power to nickel(II) ion. A new measure for solvent donor abilityMegumu Munakata, Susumu Kitagawa, and Masaharu MiyazimaCite this: Inorg. Chem. 1985, 24, 11, 1638–1643Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1 May 1985https://pubs.acs.org/doi/10.1021/ic00205a009https://doi.org/10.1021/ic00205a009research-articleACS PublicationsRequest reuse permissionsArticle Views2737Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
DESIGN OF BROADBAND CIRCULAR POLARIZATION TRUNCATED HORN ANTENNA WITH SINGLE FEED (2011)

This paper presents the design of a broadband circular polarization truncated horn antenna with single feed. It does not require any complex feeding structure and uses only a coaxial feed extended with a simple electric fleld coupling probe. The corners of the horn are truncated to generate circular polarization modes, and a broad axial ratio bandwidth which is insensitive to the probe feed dimension is achieved. Simulated and measured results of an S band truncated horn antenna are presented. The antenna has a broad 3dB axial ratio bandwidth of 26% with aperture e-ciency of 60%.
Inferring Substitutable Products with Deep Network Embedding (2019)

On E-commerce platforms, understanding the relationships (e.g., substitute and complement) among products from user's explicit feedback, such as users' online transactions, is of great importance to boost extra sales. However, the significance of such relationships is usually neglected by existing recommender systems. In this paper, we propose a semisupervised deep embedding model, namely, Substitute Products Embedding Model (SPEM), which models the substitutable relationships between products by preserving the second-order proximity, negative first-order proximity and semantic similarity in a product co-purchasing graph based on user's purchasing behaviours. With SPEM, the learned representations of two substitutable products align closely in the latent embedding space. Extensive experiments on real-world datasets are conducted, and the results verify that our model outperforms state-of-the-art baselines.
Laser embedding of TiC particles into the surface of phosphor bronze‐bearing material (2012)

A carbon film containing 5% TiC particles is formed on a pre‐prepared bronze surface prior to laser treatment. The carbon film provides increased absorption of the incident laser beam and hosts TiC particles with a uniform distribution at the workpiece surface. Optical and scanning electron microscopy are used to examine the metallurgical and morphological changes in the laser treated layer. Micro‐hardness of the laser‐treated surface is measured, and the residual stress formed in the surface vicinity is measured using the X‐ray diffraction technique. It was found that a dense layer with fine grains was formed in the laser‐treated layer. The micro‐hardness of the laser‐treated surface increases almost three times compared with the base material hardness. The presence of a dense layer and the formation of Cu 3 N in the surface region contribute to the hardness enhancement at the surface. Copyright © 2012 John Wiley & Sons, Ltd.
Detection of human group C rotaviruses in Nigeria and sequence analysis of their genes encoding VP4, VP6, and VP7 proteins (2001)

In a survey on the etiology of acute gastroenteritis in infants and young children in Nigeria, group C human rotaviruses were detected in two of 112 rotavirus positive stool specimens collected between 1999 and 2000. The VP7, VP6, and VP4 genes of the two Nigerian human group C rotavirus strains (Jajeri and Moduganari) were sequenced in this study. Comparative sequence analysis with other published human group C rotaviruses showed that the genes encoding the three structural proteins were remarkably conserved in primary structure with few mutations. The VP4 and VP7 genes from the two Nigerian strains were related more closely to each other than to those of other published strains, and formed a separate cluster on the phylogenetic tree. In contrast, it was of note that VP6 gene of strain Moduganari was related more closely to the Brazilian strain Belem than to the other Nigerian strain Jajeri. This is the first report of identification of human group C rotavirus in Nigeria and constitutes the first sequence data of human group C rotaviruses in the African continent.
Evaluation of the Arginine Maturity Index (AMI) Method of Maturity Estimation for Virginia Type Peanuts1 (1976)

Abstract The arginine maturity index (AMI) method of predicting maturity in peanuts was evaluated on Virginia type peanuts grown in the North Carolina-Virginia area. Analyses of data from a two year study showed statistical differences (P &gt; .05) of AMI values for cultivars, location and digging dates. Official grade factors suggested maturity levels consistent with AMI maturity predictions. Maximum yields per acre were observed near minimum AMI values. Optimum yields and dollars per acre were observed primarily at AMI values of 100. However, no sufficiently definitive value was determined to be the recommended point for digging peanuts. The AMI method was tested on commercial grades of shelled peanuts. Significant differences (P &gt; .05) between AMI values of cultivars were also observed.
Induction of disease resistance in common bean susceptible to halo blight bacterial pathogen after seed bacterization with rhizosphere pseudomonads. (1991)

With the aim of elucidating the immunizing ability of plant-growth-affecting rhizosphere pseudomonads, seeds of a susceptible bean (Phaseolus vulgaris L) cv. Bonita, were subjected to bacterization before challenging with the halo blight bacterial pathogen Pseudomonas syringae pv. phaseolicola. In the greenhouse, induced systemic resistance to halo blight was found in bean plants treated with a plant growth stimulatory strain of P. fluorescens (S 97), whereas deleterious pseudomonads MA 250 and VS 50 were found to induce susceptibility towards the disease. Immunization ability of S 97 was reduced at low inoculum densities (<107 live cells per ml) or eliminated when the suspension was autoclaved. The maximum disease protection, measured in terms of number of halo blight lesions in trifoliate leaves, was obtained at the highest inoculum concentration (108 live cells per ml). Agar diffusion assay in vitro revealed that S 97 exhibits bacteriostatic activity against the bean pathogen. It is suggested that S 97 might evolve substances already during seed germination that are translocated to the foliage; there they might accumulate around the site of bacterial multiplication and contribute to their restricted growth.
Use of substitute Nonidet P-40 nonionic detergents in intracellular tubulin polymerization assays for screening of microtubule targeting agents (2017)

Shell Chemical Company Nonidet P-40 has been used for decades in many biochemical assays as a nonionic, nondenaturing detergent; however, Shell no longer manufactures this product. Four commercially available substitutes were investigated and their activities titrated in an intracellular tubulin polymerization assay. Although claimed by the supply companies to be identical to the Shell Nonidet P-40, all four substitutes were about 10-fold more potent and needed to be diluted accordingly. As microtubule targeting drugs are a major class of anticancer agent, and many researchers use the intracellular tubulin polymerization assay, this information is important to help troubleshoot assay development with the new substitutes. As the Shell Nonidet P-40 has been used in many biochemical buffers, these results will be of general interest to the biochemical, cell, and molecular research community.
Automatic needle segmentation in 3D ultrasound images using 3D improved Hough transform (2008)

3D ultrasound (US) is a new technology that can be used for a variety of diagnostic applications, such as obstetrical, vascular, and urological imaging, and has been explored greatly potential in the applications of image-guided surgery and therapy. Uterine adenoma and uterine bleeding are the two most prevalent diseases in Chinese woman, and a minimally invasive ablation system using a needle-like RF button electrode is widely used to destroy tumor cells or stop bleeding. To avoid accidents or death of the patient by inaccurate localizations of the electrode and the tumor position during treatment, 3D US guidance system was developed. In this paper, a new automated technique, the 3D Improved Hough Transform (3DIHT) algorithm, which is potentially fast, accurate, and robust to provide needle segmentation in 3D US image for use of 3D US imaging guidance, was presented. Based on the coarse-fine search strategy and a four parameter representation of lines in 3D space, 3DIHT algorithm can segment needles quickly, accurately and robustly. The technique was evaluated using the 3D US images acquired by scanning a water phantom. The segmentation position deviation of the line was less than 2mm and angular deviation was much less than 2°. The average computational time measured on a Pentium IV 2.80GHz PC computer with a 381×381×250 image was less than 2s.
Characteristics of Infantile Hemangiomas as Clues to Pathogenesis (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Substituent Distribution in Hydroxyethyl Starch (1977)

Abstract The substituent distribution of hydroxyethyl starch has been determined at various degrees of substitution (MS = 0.03–1.9) by capillary gas chromatography of the silylated hydrolysate. In the monosubstituted derivatives 70–80% of the hydroxyethyl groups is attached to the C2 atom. The ratio of C3 to C6 monohydroxyethylated products changes from 2 to 0.2 when increasing the MS from 0.03 to 1.9. At high MS (around 2) the disubstituted products consist for about 50% of 2‐hydroxyethoxyethyl derivative, which indicates a strong preference for the consecutive reaction of the newly formed hydroxyl group of 2 hydroxyethyl‐anhydroglucose. The distribution of mono‐ and polysubstituted products is in agreement with a model of consecutive reactions with average relative rate constants for mono‐, di‐ and higher substitution of 1.30, 1.05 and 0.85 respectively.
Sirolimus and Thrombotic Microangiopathy after Allogeneic Stem Cell Transplantation. (2004)

Abstract Sirolimus (SRL) is a novel immunosuppressive agent that has been demonstrated to reduce GVHD and minimize morbidity after allogeneic stem cell transplantation (alloSCT). We have described a syndrome of thrombotic microangiopathy (TMA), characterized by microangiopathic hemolysis, thrombocytopenia, and renal dysfunction, whose incidence is increased when SRL is used in association with calcineurin inhibitors (CIs) but not with SRL monotherapy. To determine if SRL use potentiates the effects of CIs on TMA incidence and risk factors, we performed a retrospective cohort analysis of subjects who underwent alloSCT between 1997 and 2003. Methods: Subjects who received a SRL-containing GVHD prophylaxis after a myeloablative preparative regimen were compared with a cohort who received a non-SRL regimen. All subjects received CIs. Diagnosis of TMA required the simultaneous occurrence of: (1) creatinine elevation >2 mg/dL or >50% above baseline, (2) schistocytosis, (3) elevated LDH, and (4) no laboratory evidence of disseminated intravascular coagulopathy. Results: 111 patients who received SRL were compared with 216 patients who received no SRL during the first 100 days after alloSCT. The two groups of patients were balanced for demographic parameters; however, more patients in the SRL group received peripheral blood stem cells (50.5 vs. 18.1%, p<0.01) and had unrelated donors (58.6 vs. 42.6%, p<0.01). The incidence of TMA in the SRL group was 10.8% in comparison with an incidence of 4.2% in the non-SRL group (OR 2.57, p=0.03). Patients who received SRL developed TMA earlier than those who did not receive SRL (median 25 vs. 58 days, p=0.04). At the time of TMA diagnosis, median blood levels of immunosuppressive medications were in their respective therapeutic ranges: SRL (study group) 6.1 ng/ml, tacrolimus (study group) 9.9 ng/ml, tacrolimus (control group) 9.1 ng/ml; cyclosporine (control group) 418 ng/ml. In a multivariable logistic regression model, only the use of SRL (Adjusted Exact OR 3.49, p =0.02) and grade II-IV acute GVHD (Adjusted Exact OR 6.60, p = 0.0002) predicted the occurrence of TMA. Treatment of TMA consisted of discontinuation or dose adjustment of CIs. SRL was discontinued or dosed according to serum level. Two subjects in each group required temporary hemodialysis, and 3 subjects (1 SRL, 2 non-SRL) underwent plasmapheresis. 78% of surviving SRL-treated subjects regained normal renal function. No subject had a TMA recurrence if SRL was reintroduced. Overall survival after TMA diagnosis was better for SRL patients than non-SRL patients (58.3 vs. 11.1%, log rank p=0.02). Conclusion: SRL use is associated with an increased risk of TMA after alloSCT and may act by potentiating the effects of CIs. TMA associated with SRL appears reversible and does not affect overall survival after alloSCT. A careful monitoring strategy for TMA should be employed as part of a SRL-containing GVHD prophylaxis regimen.