gebhart/patrepeval huggingface dataset:
Questions sanitaires à propos des derniers rapports épidémiologiques de la section d'hygiène de la Société des Nations (1923)

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Concept study of Canadian hyperspectral mission (2014)

The Canadian Space Agency (CSA) has initiated several studies on possible missions addressing the needs of Canadian government departments for operational land and ocean applications. Three parallel studies have been completed that reviewed the requirements with an objective to identify microsatellite mission concepts. The CSA has further awarded two contracts to the Canadian industry teams to investigate the feasibility of hyperspectral imagers that are compatible with a microsatellite platform. Two different concepts of low-mass imaging systems have been proposed and studied. In order to address to the main challenges identified, the CSA has extended the two feasibility studies. This paper briefly reports the updates of the feasibility studies in the extension period and new development in the ongoing concept study of a Canadian hyperspectral mission.
Alzheimer's disease is TH17 related autoimmune disease against misfolded beta amyloid (2011)

Abstract Alzheimer's disease is a common neurodegenerative disorder. However, its exact etiology is still unknown. There were several mechanisms proposed such as the tau hypothesis and amyloid hypothesis. However, there is evidence challenging the above two hypotheses. Here, I propose the immune-amyloid hypothesis as a mechanism for Alzheimer's disease. Th17 related autoimmunity contributes to the disease pathogenesis. Accumulation of misfolded beta amyloid can trigger heat shock protein which in turn induces TH17 immunity. By microarray analysis of peripheral blood mononuclear cells, there is up-regulation of many TH17 related molecules after Alzheimer's disease. After knowing the exact disease pathogenesis, we can develop new therapeutic strategies to prevent or treat the detrimental disorder.
Design of Dynamic Inverse Fractional-order PID Controller for High Speed Aircraft (2019)

A dynamic inverse fractional-order PID controller for high speed aircraft is designed based on the nonlinear six-degree-of-freedom coupling model, combined with the nonlinear dynamic inverse decoupling technology and fractional-order PID control technology. The fractional-order PID controller has two more adjustable parameters than the traditional PID controller, which can achieve better control effect. Based on the time-scale separation, a non-dynamic reentry model of high-speed aircraft is established, and a dual-loop controller is designed. The simulation results show that the fractional-order PID has better control quality than the traditional PID, and improves the resistance against disturbance, which guarantees the good robustness of the system.
The circadian clock of cyanobacteria (2000)

A circadian clock, with physiological characteristics similar to those of eukaryotes, functions in the photosynthetic prokaryote, cyanobacteria. The molecular mechanism of this clock has been efficiently dissected using a luciferase reporter gene that reports the status of the clock. A circadian clock gene cluster, kaiABC, has been cloned via rhythm mutants of cyanobacterium, Synechococcus, and many clock mutations mapped to the three kai genes. Although kai genes do not share any homology with clock genes so far identified in eukaryotes, analysis of their expression suggests that a negative feedback control of kaiC expression by KaiC generates the circadian oscillation and that KaiA functions as a positive factor to sustain this oscillation. BioEssays 22:10-15, 2000.
Thin Polymer Films with High Step Coverage in Microtrenches by Initiated CVD (2008)

Abstract Initiated (i)CVD is used to deposit thin films of poly(cyclohexylmethacrylate) (pCHMA) in microtrenches of depth 7 µm and widths 1‐5 µm. By changing the fractional saturation of the monomer vapor, step coverage of 0.85 is achieved for the highest aspect ratio trench studied while maintaining a deposition rate of 15 nm min −1 . An analytical model for determining the sticking probability of the initiating radical (CH 3 ) 3 CO· is developed, and is experimentally shown to be a function of the fractional saturation of the monomer vapor. For the conditions studied, the sticking probability is in the range 1.1 × 10 −2 –5.0 × 10 −2 . These results suggest that iCVD proceeds via the reaction of a vapor‐phase initiating radical with a surface‐adsorbed monomer.
Identification of QTLs for heat tolerance at the booting stage in rice （Oryza saliva L.） (2006)

The utilization of heterosis between indica and japonica rice is an important approach to improve the productivity of rice. However, the reduced productivity due to the influence of abnormal temperature on spikelet sterility has been limiting the application of the indica-japonica cross of rice. The objective of this study was to identify the quantitative traits loci （QTLs） related to the spikelet fertility of the indica-japonica cross of rice under high growth temperature. The backcross population of USSR_(5)/Guangjie 9//USSR_(5) and related molecular map were constructed. The spikelet fertility under high temperature and heat susceptibility index （HSI） of spikelet fertility were used to evaluate the tolerance of rice to heat stress at booting stage, respectively. These QTLs related to heat tolerance at the booting stage were detected on chromosomes 2, 4 and 5, respectively, which explained 6.4%-15.8% of the observed phenotypic variance. Two QTLs related to relative heat tolerance at the booting stage were detected, with LOD scoring 3.81 and 2.86 on chromosome 4 and 8, and explained 16.8% and 9.9% of the phenotypic variance, respectively. Further analysis of epistatic effected QTLs for relative heat tolerance showed that four pairs of loci exhibited interaction on 8 chromosomes, which indicated that the heat tolerance of spikelet fertility was not only controlled by main effect QTL but also influenced by gene interaction.
Burst-mode optical receiver ICs for broadband access networks (2010)

This paper provides an overview of burst-mode optical receiver ICs for broadband access networks. A passive optical network (PON) system is a cost-effective broadband access system whose use has been spreading worldwide. A key device in such a system is an optical receiver IC with a quick response and high sensitivity that realizes high efficiency in data transmission. This paper also reports burst-mode optical receiver ICs fabricated using 0.25-μm SiGe BiCMOS technologies for a 10G-EPON system, which is a promising access network for a next generation PON system. It features fast gain and offset controls for burst-mode operation. The results show that SiGe BiCMOS can provide high performance and cost-effective receiver ICs for 10G-class PON systems.
Using Quantitative Magnetic Resonance Imaging to Generate Disease Images of Multiple Sclerosis (2011)

Using Quantitative Magnetic Resonance Imaging to Generate Disease Images of Multiple Sclerosis
Kinetics of inhibition of monoamine oxidase using curcumin and ellagic acid (2016)

Monoamine oxidase (MAO) is involved in a variety of neurological disorders including Parkinson's disease (PD)Curcumin and ellagic acid inhibit the monoamine oxidase activityEllagic acid revealed more potent MAO type-B (MAO-B) inhibitory activity than curcuminKinetic studies of MAO inhibition using different concentrations of curcumin and ellagic acid were plotted as double reciprocal Lineweaver-Burk plotThe mode of inhibition of both compounds toward MAO-B is mixed (competitive and uncompetitive) type of inhibition with both the competitive and noncompetitive type of inhibitions. Abbreviations used: MAO: Monoamine oxidase, IC50: Higher half maximal inhibitory concentrations, PD: Parkinson's disease, LB: Lewy bodies, SNpc: Substantia nigra pars compacta, ROS: Reactive oxygen species, SG: Selegiline, DMC: demethoxycurcumin, BDMC: Bisdemethoxycurcumin.
Retargeting transposon insertions by the adeno-associated virus Rep protein (2012)

The Sleeping Beauty (SB), piggyBac (PB) and Tol2 transposons are promising instruments for genome engineering. Integration site profiling of SB, PB and Tol2 in human cells showed that PB and Tol2 insertions were enriched in genes, whereas SB insertions were randomly distributed. We aimed to introduce a bias into the target site selection properties of the transposon systems by taking advantage of the locus-specific integration system of adeno-associated virus (AAV). The AAV Rep protein binds to Rep recognition sequences (RRSs) in the human genome, and mediates viral integration into nearby sites. A series of fusion constructs consisting of the N-terminal DNA-binding domain of Rep and the transposases or the N57 domain of SB were generated. A plasmid-based transposition assay showed that Rep/SB yielded a 15-fold enrichment of transposition at a particular site near a targeted RRS. Genome-wide insertion site analysis indicated that an approach based on interactions between the SB transposase and Rep/N57 enriched transgene insertions at RRSs. We also provide evidence of biased insertion of the PB and Tol2 transposons. This study provides a comparative insight into target site selection properties of transposons, as well as proof-of-principle for targeted chromosomal transposition by composite protein-protein and protein-DNA interactions.
Chaotic phase synchronization in a modular neuronal network of small-world subnetworks (2011)

We investigate the onset of chaotic phase synchronization of bursting oscillators in a modular neuronal network of small-world subnetworks. A transition to mutual phase synchronization takes place on the bursting time scale of coupled oscillators, while on the spiking time scale, they behave asynchronously. It is shown that this bursting synchronization transition can be induced not only by the variations of inter- and intra-coupling strengths but also by changing the probability of random links between different subnetworks. We also analyze the effect of external chaotic phase synchronization of bursting behavior in this clustered network by an external time-periodic signal applied to a single neuron. Simulation results demonstrate a frequency locking tongue in the driving parameter plane, where bursting synchronization is maintained, even with the external driving. The width of this synchronization region increases with the signal amplitude and the number of driven neurons but decreases rapidly with the network size. Considering that the synchronization of bursting neurons is thought to play a key role in some pathological conditions, the presented results could have important implications for the role of externally applied driving signal in controlling bursting activity in neuronal ensembles.
Customer Switching Systems (1971)

Many customers for Picturephone® service will likely be business and industrial enterprises, having PBX, centrez, or key telephone service. This paper discusses switching systems for business customers, and describes how Picturephone service will be added as a natural extension of telephone service. This paper also serves as an introduction to the detailed papers which describe each of the customer switching system Picturephone arrangements.
Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors (2007)

Throughout the world many people use artificial sweeteners (AS) for the purpose of reducing caloric intake. The most prominently used of these molecules include saccharin, aspartame (Nutrasweet), acesulfame-K, and cyclamate. Despite the caloric advantage they provide, one key concern in their use is their aversive aftertaste that has been characterized on a sensory level as bitter and/or metallic. Recently, it has been shown that the activation of particular T2R bitter taste receptors is partially involved with the bitter aftertaste sensation of saccharin and acesulfame-K. To more fully understand the biology behind these phenomena we have addressed the question of whether AS could stimulate transient receptor potential vanilloid-1 (TRPV1) receptors, as these receptors are activated by a large range of structurally different chemicals. Moreover, TRPV1 receptors and/or their variants are found in taste receptor cells and in nerve terminals throughout the oral cavity. Hence, TRPV1 activation could be involved in the AS aftertaste or even contribute to the poorly understood metallic taste sensation. Using Ca(2+) imaging on TRPV1 receptors heterologously expressed in the human embryonic kidney (HEK) 293 cells and on dissociated primary sensory neurons, we find that in both systems, AS activate TRPV1 receptors, and, moreover, they sensitize these channels to acid and heat. We also found that TRPV1 receptors are activated by CuSO(4), ZnSO(4), and FeSO(4), three salts known to produce a metallic taste sensation. In summary, our results identify a novel group of compounds that activate TRPV1 and, consequently, provide a molecular mechanism that may account for off tastes of sweeteners and metallic tasting salts.
Antioxidant activity of minor amounts of γ‐tocopherol in natural triacylglycerols (1997)

Abstract The effects of minor amounts of γ‐tocopherol on the oxidation of natural triacylglycerols (TAG) of rapeseed (RO) and butter oils (BO) were studied. Four different TAG materials were blended from chromatographically purified TAG that contained 100–25% of RO TAG. The RO TAG contained from <1 to 43 µg γ‐tocopherol per gram of TAG, which corresponded to ≤6% of the total tocopherols in the original RO. The TAG were held at 40°C in the dark for 4 wk and followed at regular intervals by measurements of hydroperoxide formation by peroxide values and of secondary product formation by p ‐anisidine values at regular intervals. In all TAG, minor amounts of γ‐tocopherol retarded oxidation. In RO TAG, concentrations as low as 11 µg/g of γ‐tocopherol (1.5% of the total tocopherols in the original RO) were enough to decrease hydroperoxide and secondary product formation to 46 and 39%, respectively. The effect was even more important in TAG mixtures that contained BO TAG. There were no significant differences between oxidation of the RO TAG at 24 µg/g, the 75% RO TAG mixture at 11 µg/g, and the 50% RO TAG mixture at 3 µg/g of γ‐tocopherol. Even at these minor levels, γ‐tocopherol was a significant antioxidant, which is important in oxidation studies of purified model systems.
On n-detection test sets and variable n-detection test sets for transition faults (2003)

We study the effectiveness of n-detection test sets based on transition faults in detecting defects that affect the timing behavior of a circuit. We use path delay faults as surrogates for unmodeled defects, and show that the path delay fault coverage achieved by an n-detection transition fault test set increases significantly as n is increased. We also introduce a method to reduce the number of tests included in an n-detection test set by using different values of n for different faults based on their potential effect on the defect coverage. The resulting test sets are referred to as variable n-detection test sets.
Comparative Evaluation of the Severity of Gastric Ulceration by Solid Dispersions and Coprecipitates of Indomethacin (1997)

The ulcerogenic activity of indomethacin was studied in rats following single and chronic doses of indomethacin in the form of pure drug, solid dispersions and coprecipitates. Each formulation was administrated as a suspension in a 2% methylcellulose solution. Gastrointestinal ulceration was assessed, four hours after a single dose and 24 hours following the last dose of a chronic four day dosing regimen, by counting the number of lesions and ulcers present. A rating scale was employed to evaluate the severity index. The coprecipitate formulation produced less severe ulceration than the solid dispersion and pure drug. This suggests that the severity of ulceration than the solid dispersion and pure drug. This suggests that the severity of ulceration may be related to the preparation methodology and drug release kinetics.
A design methodology for the exploitation of high level communication synthesis (2004)

In this paper we analyse some methodological concerns that have to be faced in a design flow which contains automatic synthesis phases from high-level, system descriptions. In particular, the issues related to the synthesis of the communication between the system elements are considered. The context in which the analysis is performed is the design flow proposed in the ODETTE project: in this ambient, systemC is exploited in order to provide efficient system-level models; after that, the systemC+ systemC subset and extensions can be used to get a refined description that, despite the use of object oriented features such as polymorphism and inheritance, can be automatically synthesised by means of the ODETTE tools. Still, the problem of interfacing the hardware synthesised with the other elements of the design (memories, peripherals) remains an important issue. In order to face this problem, we propose a pattern that can be used to design bus interfaces that allow both an high level of abstraction in the communication on the user side, and automatic synthesis by the ODETTE tools. In order to do this, OSSS global objects are exploited to implement the communication between the application and the interface. After presenting the general methodology, a specific library interface is presented, that could connect the device under design to a PCI bus. In order to prove the viability of the approach, an example of synthesis of an example, from the system level down to the RT level is performed.
Factors Influencing Glabridin Stability (2010)

Glabridin, a polyphenolic isoflavan of Glycyrrhiza glabra, has shown a variety of pharmaceutical properties. We have previously studied the isolation of glabridin using macroporous resin and found that it is partially degraded, giving a dark color. To illustrate the degradation of glabridin, the present work studied the stability of glabridin under various conditions. Licorice extract containing about 20% glabridin, obtained from G. glabra by silica gel column chromatography, was used in the stability study. Seven different factors (temperature, illumination, humidity, pH, solvent, oxygen, and oxidant) were studied and content changes were determined through HPLC analysis. Except for oxygen, all the above factors had an effect on the stability of glabridin, with illumination being the main one. Moreover, the interactions between temperature and pH, temperature and humidity, and illumination and pH can promote the degradation of glabridin. In conclusion, we suggest that a dark, dry and airtight environment provides the optimized condition for the long-term storage of glabridin.
Probing elastic modulus and depth of bottom-supported inclusions in model tissues using piezoelectric cantilevers (2007)

We have experimentally investigated the depth sensitivity limit of a piezoelectric cantilever tissue elastic modulus sensor and simultaneously determined the elastic modulus and the depth of a tumor directly. Using model tissues consisting of bottom-supported modeling clay inclusions of various depths in a gelatin matrix, we empirically determined that the depth sensitivity limit of a piezoelectric cantilever sensor was twice the linear dimension of the indentation area (or the cantilever width). Knowing the depth sensitivity limit of the individual cantilever sensor as input and treating a model tissue that has the gelatin matrix on top and the modeling clay inclusion at the bottom as two springs in series, we showed that the elastic moduli and depths of the hard inclusions could be simultaneously determined with the elastic modulus profiles measured by two cantilevers with different widths as input.
Novel, Versatile, and Tightly Regulated Expression System for <i>E</i> <i>scherichia coli</i> Strains (2010)

A novel tightly regulated gene expression system was developed for Escherichia coli by applying the regulatory elements of the Pseudomonas putida F1 cym and cmt operons to control target gene expression at the transcriptional level by using p-isopropylbenzoate (cumate) as an inducer. This novel expression system, referred to as the cumate gene switch, includes a specific expression vector, pNEW, that contains a partial T5 phage promoter combined with the Pseudomonas-based synthetic operator and the cymR repressor protein-encoding gene designed to express constitutively in the host strain. The induction of transcription relies on the addition of the exogenous inducer (cumate), which is nontoxic to the culture, water soluble, and inexpensive. The characteristics and potential of the expression system were determined. Using flow cytometry and fed-batch fermentations, we have shown that, with the newly developed cumate-regulated system, (i) higher recombinant product yields can be obtained than with the pET (isopropyl-beta-D-thiogalactopyranoside [IPTG])-induced expression system, (ii) expression is tightly regulated, (iii) addition of cumate quickly results in a fully induced and homogenous protein-expressing population in contrast to the bimodal expression profile of an IPTG-induced population, (iv) expression can be modulated by varying the cumate concentration, and (v) the cumate-induced population remains induced and fully expressing even at 8 h following induction, resulting in high yields of the target protein Furthermore, the cumate gene switch described in this article is applicable to a wide range of E. coli strains.
Type I Phosphatidylinositol-4-phosphate 5-Kinases Synthesize the Novel Lipids Phosphatidylinositol 3,5-Bisphosphate and Phosphatidylinositol 5-Phosphate (1998)

Inositol phospholipids regulate a variety of cellular processes including proliferation, survival, vesicular trafficking, and cytoskeletal organization. Recently, two novel phosphoinositides, phosphatidylinositol-3,5-bisphosphate (PtdIns-3,5-P2) and phosphatidylinositol- 5-phosphate (PtdIns-5-P), have been shown to exist in cells. PtdIns-3,5-P2, which is regulated by osmotic stress, appears to be synthesized by phosphorylation of PtdIns-3-P at the D-5 position. No evidence yet exists for how PtdIns-5-P is produced in cells. Understanding the regulation of synthesis of these molecules will be important for identifying their function in cellular signaling. To determine the pathway by which PtdIns-3,5-P2 and Ptd-Ins-5-P might be synthesized, we tested the ability of the recently cloned type I PtdIns-4-P 5-kinases (PIP5Ks) alpha and beta to phosphorylate PtdIns-3-P and PtdIns at the D-5 position of the inositol ring. We found that the type I PIP5Ks phosphorylate PtdIns-3-P to form PtdIns-3,5-P2. The identity of the PtdIns-3,5-P2 product was determined by anion exchange high performance liquid chromatography analysis and periodate treatment. PtdIns-3,4-P2 and PtdIns-3,4,5-P3 were also produced from PtdIns-3-P phosphorylation by both isoforms. When expressed in mammalian cells, PIP5K Ialpha and PIP5K Ibeta differed in their ability to synthesize PtdIns-3,5-P2 relative to PtdIns-3,4-P2. We also found that the type I PIP5Ks phosphorylate PtdIns to produce PtdIns-5-P and phosphorylate PtdIns-3,4-P2 to produce PtdIns-3,4,5-P3. Our findings suggest that type I PIP5Ks synthesize the novel phospholipids PtdIns-3,5-P2 and PtdIns-5-P. The ability of PIP5Ks to produce multiple signaling molecules indicates that they may participate in a variety of cellular processes.