gebhart/patrepeval huggingface dataset:
ZIKV – CDB: A Collaborative Database to Guide Research Linking SncRNAs and ZIKA Virus Disease Symptoms (2016)

We have computationally predicted both miRNAs encoded by ZIKV able to target genes in the human genome and cellular (human) miRNAs capable of interacting with ZIKV genomes. Our results represent a step forward in the ZIKV studies, providing new insights to support research in this field and identify potential targets for therapy.
Critical-Path-Aware X-Filling for Effective IR-Drop Reduction in At-Speed Scan Testing (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
MR Ratio Enhancement by NOL Current-Confined-Path Structures in CPP Spin Valves (2004)

We have compared the magnetoresistance (MR) performance of current-confined-path (CCP) current-perpendicular-to-plane giant magnetoresistance (CPP-GMR) spin valve films with a nano-oxide-layer (NOL), made between natural oxidation (NO) and ion-assisted oxidation (IAO). For the NO, an MR ratio was only 1.5% at an RA of 370 m/spl Omega//spl mu/m/sup 2/, whereas for the IAO, an MR ratio was greatly increased to 5.4% at an RA of 500 m/spl Omega//spl mu/m/sup 2/. Fitted data by the Valet-Fert model showing larger MR enhancement effect by the IAO is explained by the improvement of the metal-purity of the Cu inside the CCP structure. By further improvement of metal-purity of the Cu, a large MR ratio of more than 30% can be expected at a small RA of 300 m/spl Omega//spl mu/m/sup 2/. The CCP-CPP spin valve film is a promising candidate for realizing high-density recording heads for 200 to 400-Gbpsi recording.
Single Event Transients in Linear Integrated Circuits (2005)

On November 5, 2001, a processor reset occurred on board the Microwave Anisotropy Probe (MAP), a NASA mission to measure the anisotropy of the microwave radiation left over from the Big Bang. The reset caused the spacecraft to enter a safehold from which it took several days to recover. Were that to happen regularly, the entire mission would be compromised, so it was important to find the cause of the reset and, if possible, to mitigate it. NASA assembled a team of engineers that included experts in radiation effects to tackle the problem. The first clue was the observation that the processor reset occurred during a solar event characterized by large increases in the proton and heavy ion fluxes emitted by the sun. To the radiation effects engineers on the team, this strongly suggested that particle radiation might be the culprit, particularly when it was discovered that the reset circuit contained three voltage comparators (LM139). Previous testing revealed that large voltage transients, or glitches appeared at the output of the LM139 when it was exposed to a beam of heavy ions [NI96]. The function of the reset circuit was to monitor the supply voltage and to issue a reset command to the processor should the voltage fall below a reference of 2.5 V [PO02]. Eventually, the team of engineers concluded that ionizing particle radiation from the solar event produced a negative voltage transient on the output of one of the LM139s sufficiently large to reset the processor on MAP. Fortunately, as of the end of 2004, only two such resets have occurred. The reset on MAP was not the first malfunction on a spacecraft attributed to a transient. That occurred shortly after the launch of NASA s TOPEX/Poseidon satellite in 1992. It was suspected, and later confirmed, that an anomaly in the Earth Sensor was caused by a transient in an operational amplifier (OP-15) [KO93]. Over the next few years, problems on TDRS, CASSINI, [PR02] SOHO [HA99,HA01] and TERRA were also attributed to transients. In some cases, such events produced resets by falsely triggering circuits designed to protect against over- voltage or over-current. On at least three occasions, transients caused satellites to switch into safe mode in which most of the systems on board the satellites were powered down for an extended period. By the time the satellites were reconfigured and returned to full operational state, much scientific data had been lost. Fortunately, no permanent damage occurred in any of the systems and they were all successfully re-activated.
Affinity of Spotted Cucumber Beetle (Coleoptera: Chrysomelidae) Larvae to Cucurbitacins (1991)

Adults of several species of cucumber beetles compulsively eat bitter triterpene cucurbitacins, but it is unknown if their larvae exhibit the same behavior. The affinity of spotted cucumber beetle larvae to cucurbitacins was tested by performing feeding choice experiments using bitter ( Cucurbita andreana Naudin) and nonbitter ( C. palmeri Bailey) root cuttings and nonbitter roots of Cucumis sativas L. coated exogenously with cucurbitacin B. Within a 24-h period, larvae ate significantly more of the bitter than the nonbitter roots in both experiments.
Algorithms for restriction map comparisons (1984)

An algorithm is presented which compares two restriction maps, yielding a measure of distance between the maps and relating the maps by an alignment. This new algorithm finds the minimum weighted sum of genetic events required to convert one map into the other, where the genetic events are the appearance/disappearance of restriction sites and changes in the number of bases between restriction sites. The algorithm is illustrated by comparison of the beta-delta region of the globin gene cluster of four primate species. The results are in excellent agreement with known evolutionary relationships.
Surgery of small hepatocellular carcinoma. Analysis of 144 cases (1989)

A long-term follow-up study of 144 cases with surgically and pathologically proved small hepatocellular carcinoma (less than or equal to 5 cm) from 1967 to 1987 is reported. One hundred eight cases (75.0%) were detected by alpha-fetoprotein serosurvey and/or ultrasonography mainly in a high-risk population; 129 cases (89.6%) coexisted with cirrhosis. Resection was done in 132 cases (91.7%) with three (2.3%) operative deaths; cryosurgery, laser vaporization, and hepatic arterial chemotherapy were used in the rest. Limited resection was done in 67.4% of resections. Reresection of subclinical recurrence or solitary pulmonary metastasis was done in 21 cases. The 5-year and 10-year survival rates were 67.9% and 53.4% in the resection group but zero in the nonresection group. Survival was correlated negatively with tumor size, 5-year survival after resection was 84.6% in tumors less than or equal to 2 cm but 59.5% in tumors of 4.1 to 5 cm. The increase of resectability and reresection resulted in marked improved of 5-year survival from 43.5% in 1973 to 1977 to 63.3% in 1978 to 1982 in the entire series. No significant difference was found between survival of limited resection and lobectomy. Resection may be the modality of choice for treatment of small hepatocellular carcinomas with compensated liver function. Limited resection instead of lobectomy was the key to increased resectability and decreased operative mortality in cirrhotic livers. Reresection of subclinical recurrence was important to prolong survival further.
Discovering the Balance of Steric and Electronic Factors Needed To Provide a New Structural Motif for Photocatalytic Hydrogen Production from Water (2011)

Ru,Rh,Ru supramolecules are known to undergo multielectron photoreduction and reduce H(2)O to H(2). Ru,Rh bimetallics were recently shown to photoreduce but not catalyze H(2)O reduction. Careful tuning of sterics and electronics for [(TL)(2)Ru(dpp)RhCl(2)(TL')](3+) produce active bimetallic photocatalysts (TL = terminal ligand). The system with TL,TL' = Ph(2)phen photocatalytically reduces H(2)O to H(2) while TL,TL' = phen,bpy or bpy,(t)Bu(2)bpy do not.
Mechanism and Regulation of Cellular Zinc Transport (2007)

Zinc is an essential cofactor for the activity and folding of up to ten percent of mammalian proteins and can modulate the function of many others. Because of the pleiotropic effects of zinc on every aspect of cell physiology, deficits of cellular zinc content, resulting from zinc deficiency or excessive rise in its cellular concentration, can have catastrophic consequences and are linked to major patho-physiologies including diabetes and stroke. Thus, the concentration of cellular zinc requires establishment of discrete, active cellular gradients. The cellular distribution of zinc into organelles is precisely managed to provide the zinc concentration required by each cell compartment. The complexity of zinc homeostasis is reflected by the surprisingly large variety and number of zinc homeostatic proteins found in virtually every cell compartment. Given their ubiquity and importance, it is surprising that many aspects of the function, regulation, and crosstalk by which zinc transporters operate are poorly understood. In this mini-review, we will focus on the mechanisms and players required for generating physiologically appropriate zinc gradients across the plasma membrane and vesicular compartments. We will also highlight some of the unsolved issues regarding their role in cellular zinc homeostasis.
All-optical enhancement of clock and clock-to-data suppression ratio of NRZ data (2001)

A scheme for all-optical enhancement of clock and clock-to-data suppression ratio of nonreturn-to-zero (NRZ) data based on self-phase modulation is proposed and demonstrated. More than 3-dB clock enhancement and 11-dB clock-to-data suppression ratio enhancement has been realized by a semiconductor optical amplifier (SOA) and fiber Bragg grating (FBG) in reflection. Clock enhancement of more than 6 dB is possible using a FBG in transmission. Using this technique, all-optical clock recovery from NRZ data has been demonstrated.
Why People Continue to Play Online Games: In Search of Critical Design Factors to Increase Customer Loyalty to Online Contents (2004)

As people increasingly play online games, numerous new features have been proposed to increase players' log-on time at online gaming sites. However, few studies have investigated why people continue to play certain online games or which design features are most closely related to the amount of time spent by players at particular online gaming sites. This study proposes a theoretical model using the concepts of customer loyalty, flow, personal interaction, and social interaction to explain why people continue to play online network games. The study then conducts a large-scale survey to validate the model. Finally, it analyzes current online games to identify design features that are closely related to the theoretical concepts. The results indicate that people continue to play online games if they have optimal experiences while playing the games. This optimal experience can be attained if the player has effective personal interaction with the system or pleasant social interactions with other people connected to the Internet. Personal interaction can be facilitated by providing appropriate goals, operators and feedback; social interaction can be facilitated through appropriate communication places and tools. This paper ends with the implications of applying the study results to other domains such as e-commerce and cyber communities.
Catalytic performance of Ru_xCo_ySe_z nano-cluster towards cathode oxygen reduction reaction (2011)

The RuxCoySez nanometric cluster was synthesized by reacting dodecacarbonyltriuthenium [Ru3(CO)12],dodecacarbonyltetracobalt [Co4(CO)12] and selenium in 1,6-hexanediol solvent under refluxing conditions.The phase structure and morphology of the synthesized catalyst was characterized by SEM and XRD techniques.The catalyst maintained the hexagonal structure of Rux cluster as the main phase,formed an amorphous phase and presented a high uniformity of agglomerated nanocrystalline particles.The electrocatalytic activity of the catalyst towards oxygen reduction reaction(ORR) was investigated by the rotating disk electrode(RDE) technique.The RuxCoySez catalyst showed higher catalytic activity towards ORR and electrochemical stability in 0.5 mol L-1 H2SO4 solution than that obtained with RuxSey,and had the open circuit potential of 0.91 V(vs.NHE).
Requirement of mosXe protein kinase for meiotic maturation of Xenopus oocytes induced by a cdc2 mutant lacking regulatory phosphorylation sites. (1992)

The p34cdc2 protein kinase is a component of maturation-promoting factor, the master regulator of the cell cycle in all eukaryotes. The activity of p34cdc2 is itself tightly regulated by phosphorylation and dephosphorylation. Predicted regulatory phosphorylation sites of Xenopus p34cdc2 were mutated in vitro, and in vitro-transcribed RNAs were injected into Xenopus oocytes. The cdc2 single mutants Thr-14----Ala and Tyr-15----Phe did not induce germinal vesicle breakdown (BVBD) upon microinjection into oocytes. In contrast, the cdc2 double mutant Ala-14/Phe-15 did induce GVBD. Both the Ala-14 and Ala-14/Phe-15p34cdc2 mutants were shown to coimmunoprecipitate cyclin B1 and to phosphorylate histone H1 in immune complex kinase assays. Microinjection of antisense oligonucleotides to c-mosXe was used to demonstrate the role of mos protein synthesis in the induction of GVBD by the Ala-14/Phe-15 cdc2 mutant. Thr-161 was also mutated. p34cdc2 single mutants Ala-161 and Glu-161 and triple mutants Ala-14/Phe-15/Ala-161 and Ala-14/Phe-15/Glu-161 failed to induce GVBD in oocytes and showed a decreased binding to cyclin B1 in coimmunoprecipitations. Each of the cdc2 mutants was also assayed by coinjection with cyclin B1 or c-mosXe RNA into oocytes. Several of the cdc2 mutants were found to affect the kinetics of cyclin B1 and/or mos-induced GVBD upon coinjection, although none affected the rate of progesterone-induced maturation. We demonstrate here the significance of Thr-14, Tyr-15, and Thr-161 of p34cdc2 in Xenopus oocyte maturation. In addition, these results suggest a regulatory role for mosXe in induction of oocyte maturation by the cdc2 mutant Ala-14/Phe-15.
Fabrication and cold test of photonic band gap resonators and accelerator structures (2005)

We present the detailed description of the successful design and cold test of photonic band gap (PBG) resonators and traveling-wave accelerator structures. Those tests provided the essential basis for later hot test demonstration of the first PBG accelerator structure at 17.140 GHz [E. I. Smirnova, A. S. Kesar, I. Mastovsky, M. A. Shapiro, and R. J. Temkin, Phys. Rev. Lett., 95, 074801 (2005).]. The advantage of PBG resonators is that they were built to support only the main, ${\mathrm{TM}}_{01}$-like, accelerator mode while not confining the higher-order modes (HOM) or wakefields. The design of the PBG resonators was based on a triangular lattice of rods, with a missing rod at the center. Following theoretical analysis, the rod radius divided by the rod spacing was held to a value of about 0.15 to avoid supporting HOM. For a single-cell test the PBG structure was fabricated in X-band (11 GHz) and brazed. The mode spectrum and $Q$ factor ($Q=5\text{ }000$) agreed well with theory. Excellent HOM suppression was evident from the cold test. A six-cell copper PBG accelerator traveling-wave structure with reduced long-range wakefields was designed and was built by electroforming at Ku-band (17.140 GHz). The structure was tuned by etching the rods. Cold test of the structure yielded excellent agreement with the theoretical design. Successful results of the hot test of the structure demonstrating the acceleration of the electron beam were published in E. I. Smirnova, A. S. Kesar, I. Mastovsky, M. A. Shapiro, and R. J. Temkin, Phys. Rev. Lett., 95, 074801 (2005).
Non‐invasive multiphoton imaging of extracellular matrix structures (2008)

Multiphoton microscopy has become a powerful method for the artifact-free, nondestructive evaluation of deep-tissue cells and extracellular matrix (ECM) structures in their native environment. By interacting with highly non-centrosymmetric molecular assemblies such as fibrillar collagen, the non-linear process called second harmonic generation (SHG) has also proven to be an important diagnostic tool for the visualization of ECM compartments in situ with submicron resolution without the need for tissue processing. This review reports on applications of multiphoton-induced autofluorescence and SHG microscopy to identify collagen and elastic fiber orientation in native, tissue-engineered and processed, as well as healthy and diseased, tissues and organs. SHG signal profiling was used to quantify ECM damage in various cardiovascular and exocrine tissues, as well as cartilage. These novel imaging modalities open the general possibility of high-resolution in situ and more important in vivo imaging of ECM structures, cells and intracellular organelles in living intact tissues.
Long-term culture and functional characterization of follicular cells from adult normal human thyroids. (1994)

We have obtained long-term cultures of differentiated proliferating follicular cells from normal adult human thyroid glands. In vitro growth of such human cells has been sustained by a modified F-12 medium, supplemented with bovine hypothalamus and pituitary extracts and no added thyrotropin. Cultures have been expanded, cloned, frozen, successfully retrieved, and characterized. Functional characterization of these cells shows constitutive thyroglobulin production and release and thyrotropin-dependent adenosine 3',5'-cyclic monophosphate production, the latter apparently not associated with significant increases in DNA synthesis or cell proliferation. Genetic characterization of these cells by chromosome counting showed the normal diploid chromosome number. The ability to cultivate differentiated human thyroid follicular cells in long-term culture opens possibilities for investigating the transduction pathways of thyrotropin stimulation in normal and pathological human tissues, developing clinically relevant in vitro assays, and considering cellular and molecular therapies.
Makeup color reproduction based on spectrum data (2013)

A variety of internet services closely related with our daily lives are currently being provided due to the advances in information technology and computer industry. Among those services, virtual simulation applications can enable customers to experience various products before they purchase them. An example of such services is a virtual makeup simulation that allows customers to try cosmetics, hair styles, and accessories virtually on their facial images. Those services help people to make a decision when they purchase the products at the stores. However, most of current virtual makeup solutions and products are not realistic enough to precisely simulate makeup procedures and to predict appearances of the users after the makeup procedure is complete. One of the most significant problems is that simulation results are represented with simple RGB color channels without considering characteristics of color equipment such as cameras and monitors. A solution to those problems is color reproduction technology that determines color values that are displayed on monitors by developing color reproduction models based on measurements using special purpose measurement devices. In this paper we propose an approach to simulate makeup procedures and estimate skin colors after specific cosmetics are applied based on spectrum data of skins and cosmetics. Our approach produced a convincing simulation results with true color representation by using color equipments characterization and true color reproduction technology. Our approach based on spectral data makes it possible to represent true color of user's skin on which various cosmetics has been applied.
The Current Development and Future Needs In Modeling of Stream Sedimentation - The NCCHE Perspective (2013)

The recent advances of computer technology and numerical methods have accelerated the progress of thestate of the art in sediment transport modeling. This paper is to report recent accomplishments using thenumerical-empirical models to enhance our understanding of the sediment transport processes in streams and todevelop a cost-effective tool for engineering analysis and design to solve stream morphological problems at theNational Center for Computational Hydroscience and Engineering (NCCHE) at The University of Mississippi,and to discuss the future research needs in sediment transport modeling.
From bench to bedside and beyond: a novel therapy to improve wound healing in type 2 diabetes (2019)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Rheological Properties of Gelatinized Arrowroot Starch Solution (1987)

The rheological properties of gelatinized arrowroot stach solution followed the power law and showed a pseudoplastic behavior at the temperature range of . The flow behavior index was essentially remained constant at all temperatures, but decreased as starch concentration increased. The consistency index was exponentially increased with the increase of starch concentration. The activation energy of flow of gelatinized starch solution was .
Quantitative analysis of information loss in digital image compression and reconstruction (2011)

Digital image compression has numerous practical applications to effectively utilize storage capacities. Two basic techniques are lossless and lossy compression. The former employs probabilistic models for lossless storage on a basis of statistical redundancy occurred in digital images. However, it has limitation in compression ratio. Thus, the latter has been widely applied to further improve storage capacities, covering various fundamental digital image processing approaches. It has been documented that most lossy compression schemes will provide perfect visual perception under an exceptional compression ratio, among which discrete wavelet transform (DWT), discrete Fourier transform (DFT) and statistical optimization compression schemes (e.g., principal component analysis or independent component analysis) are dominant approaches. It is necessary to evaluate these compression and reconstruction schemes objectively. Using a well defined set of quantitative metrics by means of Information Theory, a comparative study on several typical image compression and reconstruction schemes will be made in this research.
Oxidation Chemistry of Poly(ethylene glycol)‐Supported Carbonylruthenium(<scp>II</scp>) and Dioxoruthenium(<scp>VI</scp>) <i>meso</i>‐Tetrakis(pentafluorophenyl)porphyrin (2006)

[Ru(II)(F(20)-tpp)(CO)] (1, F(20)-tpp=meso-tetrakis(pentafluorophenyl)porphyrinato dianion) was covalently attached to poly(ethylene glycol) (PEG) through the reaction of 1 with PEG and sodium hydride in DMF. The water-soluble PEG-supported ruthenium porphyrin (PEG-1) is an efficient catalyst for 2,6-Cl(2)pyNO oxidation and PhI==NTs aziridination/amidation of hydrocarbons, and intramolecular amidation of sulfamate esters with PhI(OAc)(2). Oxidation of PEG-1 by m-CPBA in CH(2)Cl(2), dioxane, or water afforded a water-soluble PEG-supported dioxoruthenium(VI) porphyrin (PEG-2), which could react with hydrocarbons to give oxidation products in up to 80 % yield. The behavior of the two PEG-supported ruthenium porphyrin complexes in water was probed by NMR spectroscopy and dynamic light-scattering measurements. PEG-2 is remarkably stable to water. The second-order rate constants (k(2)) for the oxidation of styrene and ethylbenzene by PEG-2 in dioxane-water increase with water content, and the k(2) values at a water content of 70 % or 80 % are up to 188 times that obtained in ClCH(2)CH(2)Cl.