gebhart/patrepeval huggingface dataset:
Leukemias with megakaryoblastic involvement: clinical, hematologic, and immunologic characteristics (1988)

The clinical, hematologic, and phenotypic features of 28 patients with acute leukemia with megakaryocytic involvement (AMKL) were analyzed. The prevalence of this type of leukemia in the entire series was 11.6%, with a higher incidence among patients with acute transformation of a previous myeloproliferative disorder (MPD) (24%) than among the transformed myelodysplastic syndrome (13%) patients. The incidence in the “de novo” ANLL was 8% and 16% among secondary leukemias. The presence of bone marrow fibrosis together with low WBC and normal or increased platelet counts despite a severe anemia are the most relevant features in these patients who otherwise displayed an apparently poor prognosis. Megakaryoblasts were morphologically recognized more frequently in the acute transformations of MPD than in de novo ANLL. Only two cases were considered pure AMKL, and in the remaining 26 patients, megakaryoblasts coexisted with other granulomonocytic and/or erythroid populations. Antiglycoprotein IIIa (anti-GPIIIa) (C17) and anti-GPIIb/IIIa (CDw41-, J15-) antibodies are probably the best markers for AMKL, although the monoclonal antibody against GPIX (FMC25) was also positive in a majority of cases but in a lower percentage of cells. On the other hand, megakaryoblasts were generally negative for granulocytic or monocytic markers (CD13, CD14, CD15); the expression of HLA-DR antigens in these cells was variable. Our present results indicate that megakaryoblastic involvement is more common than previously recognized. This is true not only in acute transformed leukemias but also in de novo ANLL. Although the diagnosis of these cases should be based on megakaryocytic markers, it is often possible to suspect a diagnosis according to certain clinical and hematologic features.
Cluster assembled materials: a novel class of nanostructured solids with original structures and properties (1997)

The low-energy cluster beam deposition technique (LECBD) is applied to produce cluster assembled films with hitherto unknown nanostructured morphologies and properties. Neutral clusters having the very low energy gained in the supersonic expansion at the exit of the inert gas condensation-type source are deposited without fragmentation upon impact on the substrate. Depending on the deposition conditions (nature, size and flux of incident clusters, nature and temperature of the substrate, vacuum conditions), granular nanostructures resulting from the diffusion and coalescence of supported clusters are obtained with materials of any type (covalent or metallic). A critical size for coalescence limits the supported grain size and, finally, highly porous thick films growing by random stacking of nanoparticles are obtained. A recent model developed by combining several dynamical processes simultaneously occurring on the substrate (deposition - diffusion - aggregation, DDA) is used to simulate the cluster assembled film morphology in good agreement with the experimental observations. Examples of novel materials obtained by LECBD are presented to illustrate the interesting potentialities of the technique. In the case of covalent materials such as carbon and silicon, 'amorphon'-type disordered structures, different from the conventional amorphous structures (a-C and a-Si), are obtained with some unique properties. With transition metal (Fe, Co and Ni) cluster assembled films, a specific magnetic behaviour, resulting from the competition between the intrinsic properties of the grains (magnetocrystalline anisotropy) and the interactions between grains, is observed. Also, films of clusters embedded in various co-deposited matrices are produced in order to control the interactions between grains via the matrix materials (insulating, conducting ...). Interesting optical properties (from metallic clusters in ) or giant magnetoresistance effects (from Co clusters in silver) are reported for such systems, emphasizing the future role of LECBD in various fields of applications such as optical and optoelectronic nanostructures, magnetic and magneto-optic nanostructures and quantum devices.
Polymer-Grafted-Nanoparticles Nanocomposites: Dispersion, Grafted Chain Conformation, and Rheological Behavior (2010)

We investigate the dispersion mechanisms of nanocomposites made of well-defined polymer (polystyrene, PS) grafted-nanoparticles (silica) mixed with free chains of the same polymer using a combination of scattering (SAXS/USAXS) and imaging (TEM) techniques. We show that the relevant parameter of the dispersion, the grafted/free chains mass ratio R tuned with specific synthesis process, enables to manage the arrangement of the grafted nanoparticles inside the matrix either as large and compact aggregates (R < 0.24) or as individual nanoparticles dispersion (R > 0.24). From the analysis of the interparticles structure factor, we can extract the thickness of the spherical corona of grafted brushes and correlate it with the dispersion: aggregation of the particles is associated with a significant collapse of the grafted chains, in agreement with the theoretical models describing the free energy as a combination of a mixing entropy term between the free and the grafted chains and an elastic term of deformation of the grafted brushes. At fixed grafting density, the individual dispersion of particles below the theoretical limit of R = 1 can be observed, due to interdiffusion between the grafted and the free chains but also to processing kinetics effects, surface curvature and chains poly dispersity. Mechanical analysis of nanocomposites show the appearance of a longer relaxation time at low frequencies, more pronounced in the aggregated case even without direct connectivity between the aggregates. Correlation between the local structure and the rheological behavior suggests that the macroscopic elastic modulus of the nanocomposite could be described mainly by a short-range contribution, at the scale of the interactions between grafted particles, without significant effect of larger scale organizations.
Effect of subinhibitory concentrations of mecillinam on the serum susceptibility of Escherichia coli strains (1981)

For serum-resistant clinical isolates of Escherichia coli were grown in the presence of various subinhibitory concentrations of mecillinam or pivmecillinam and then exposed to the bactericidal action of human serum. All strains became more serum susceptible as a result of pregrowth in medium containing mecillinam, but the concentration of antibiotic needed to produce the effect varied according to the strain being used. Production of ovoid or round cells was a prerequisite for sensitization to serum. Growth in the presence of mecillinam did not alter the response to serum of a serum-susceptible E. coli strain.
A Statistical Learning Model of Text Classification for Support Vector Machines (2001)

This paper develops a theoretical learning model of text classification for Support Vector Machines (SVMs). It connects the statistical properties of text-classification tasks with the generalization performance of a SVM in a quantitative way. Unlike conventional approaches to learning text classifiers, which rely primarily on empirical evidence, this model explains why and when SVMs perform well for text classification. In particular, it addresses the following questions: Why can support vector machines handle the large feature spaces in text classification effectively? How is this related to the statistical properties of text? What are sufficient conditions for applying SVMs to text-classification problems successfully?
Syntheses of 9-substituted josamycin, 13-substituted isojosamycin and their tetrahydro derivatives. (1981)

Derivatives of josamycin and isojosamycin modified at C-9 and C-13 have been prepared by reaction sequences involving treatment of josamycin with alcohols, phenol or 1-methyl-1H-tetrazol-5-ylthiol in acidic media. Several tetrahydro derivatives of josamycin and isojosamycin have also been prepared by reaction sequences involving catalytic hydrogenation. From the 1H NMR studies, it was found that the conformation of the macro-lactone portion of 13-O-methylisojosamycin dimethylacetal, a key intermediate, is flexible and changeable with variation of the solvent.
Regulation of the Nanog gene by both positive and negative <i>cis</i>‐regulatory elements in embryonal carcinoma cells and embryonic stem cells (2008)

The transcription factor Nanog is essential for mammalian embryogenesis, as well as the pluripotency of embryonic stem (ES) cells. Work with ES cells and embryonal carcinoma (EC) cells previously identified positive and negative cis-regulatory elements that influence the activity of the Nanog promoter, including adjacent cis-regulatory elements that bind Sox2 and Oct-3/4. Given the importance of Nanog during mammalian development, we examined the cis-regulatory elements required for Nanog promoter activity more closely. In this study, we demonstrate that two positive cis-regulatory elements previously shown to be active in F9 EC cells are also active in ES cells. We also identify a novel negative regulatory region that is located in close proximity to two other positive Nanog cis-regulatory elements. Although this negative regulatory region is active in F9 EC cells and ES cells, it is inactive in P19 EC cells. Furthermore, we demonstrate that one of the positive cis-regulatory elements active in F9 EC cells and ES cells is inactive in P19 EC cells. Together, these and other studies suggest that Nanog transcription is regulated by the interplay of positive and negative cis-regulatory elements. Given that P19 appears to be more closely related to a later developmental stage of mammalian development than F9 and ES cells, differential utilization of cis-regulatory elements may reflect mechanisms used during development to achieve the correct level of Nanog expression as embryogenesis unfolds.
Radio Frequency Pulsewidth Modulation (1973)

The width of a train of square pulses can be varied to produce a modulated carrier at the pulse repetition frequency. When the pulse train is generated by switching (class D) transistors, highefficiency operation is possible. The efficiency of this type of amplifier can be significantly higher than that of conventional pulsewidth modulation amplifiers, since the switching rate is reduced. In addition, the spectrum of a bipolar pulse train so modulated has the highly desirable property of all spurious products being band limited near the odd harmonics of the carrier.
Causes and treatments of lag screw's cut out after intramedullary nailing osteosinthesis for trochanteric fractures. (2014)

Background. Superior cut-out of a lag screw remains a serious complication in the treatment of trochanteric or subtrochanteric fractures and it is related to many factors: the type of fracture, osteoporosis and the stability of fracture reduction. Little is known about the outcome after revision surgery for complications of the gamma nail. We assessed the outcome in patients who had revision surgery because of lag screw's cut out after gamma nailing for a trochanteric fracture.Material and Method. We present a study of 20 consecutive patients who underwent treatment after 20 cut-out of the lag screw ﬁxation of a trochanteric fracture with Gamma Locking Nail from September 2004 to November 2010. In 16 patients hip prothesis was performed, in 1 the removal of the implant and in 3 the reosteosynthesis. We reviewed 13 patients: 10 total hip arthroplasty, 2 endoprothesis and 1 reosteosynthesis of nail and lag screw (mean follow up: 26 months, mean age: 73 years old), 7 patients died. Patients were reviewed retrospectively by an independent observer. Clinical evaluation was performed, Oxford score and Harris Hip score were measured. X-Ray examination was performed after a minimum of 12 months of follow up.Results. Mean Harris Hip Score mean was 67 and mean Oxford score was 32 in hip prothesis group (12 patients). We had several complications, Implant-related complications were: 2 ipometria > 2cm, 2 recurrent hip arthroplasty dislocations (1 reoperated), 4 persistent thigh pain. In only 4 patients none complications were observed. Another patient, who had been subjected to reosteosinthesis, obtained better results (HHS:95, Oxford score:45) but with a 2 cm ipometria and occasional pain in the thigh.Conclusion. Cut out after gamma nail is consequent to biological or mechanical causes. Treatment of this complication is hip prosthesis (parzial or total hip arthroplasty), reosteosynthesis of the lag screw and/or the nail and the removal of the implant. Conversion to total/parzial hip arthroplasty may be a demanding operation with a higher complication rate respect to the standard, while reosteosynthesis is possible in selected patients and early cutting out.
<title>Particle image velocimetry system using a high-resolution CCD camera</title> (1993)

A hardware implementation of a Particle Image Velocimetry (PIV) system, used for 2D flow field analysis, is described. This implementation incorporates a 2048 X 2048 imaging CCD camera to replace photographic film and film scanners used in other PIV implementations. Use of this camera with an array processor and specialized software allows for the near real-time presentation of PIV data at resolution approaching film. PIV system control of both pulsed illumination and camera acquisition is accomplished via a windowed user interface running on a PC compatible computer. Novel approaches to resolving both velocity direction and zero velocity measurements are presented.
Variations in Affinities of Antibodies during the Immune Response<sup>*</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleVariations in Affinities of Antibodies during the Immune Response*Herman N. Eisen and Gregory W. SiskindCite this: Biochemistry 1964, 3, 7, 996–1008Publication Date (Print):July 1, 1964Publication History Published online1 May 2002Published inissue 1 July 1964https://pubs.acs.org/doi/10.1021/bi00895a027https://doi.org/10.1021/bi00895a027research-articleACS PublicationsRequest reuse permissionsArticle Views1516Altmetric-Citations758LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Overhearing packet transmissions to reduce preamble overhead and improve throughput in IEEE 802.11 networks (2014)

While there has been a significant increase in the data rate carrying capacity of the physical medium of Wi-Fi in recent years, there has not been a proportionate increase in the application layer throughput. The primary cause for this are overheads such as those of the preamble, acknowledgement, and channel access present in the packet data communication. This paper is a proof of concept for a novel method to increase the data throughput by cutting down preamble overheads. The preamble is present in the beginning of the packet for the purposes of packet detection, automatic gain control, channel estimation and phase error correction. In 802.11, a receiver estimates the channel response afresh for every received packet using its preamble and forgets this channel estimate thereafter. This necessitates the need for a large preamble to be sent with every packet. In our method, a node remembers channel estimates from preambles of packets transmitted (to itself or to any other node) in the recent past (within a coherence time), which it reuses for future received packets. This allows transmitters to reduce the size of the preambles of some packets significantly, thereby improving throughput. We validate our method through detailed physical layer simulations of 802.11n in matlab and show that we can shorten the preamble by as much as 16's for 2×2 MIMO which would bring down the preamble overhead by as much as 50%.
Reactions of vinyl azides with .alpha.-oxo phosphorus ylides. Synthesis of N1-vinyltriazoles (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of vinyl azides with .alpha.-oxo phosphorus ylides. Synthesis of N1-vinyltriazolesP. Ykman, G. Mathys, G. L'Abbe, and G. SmetsCite this: J. Org. Chem. 1972, 37, 21, 3213–3216Publication Date (Print):October 1, 1972Publication History Published online1 May 2002Published inissue 1 October 1972https://pubs.acs.org/doi/10.1021/jo00986a004https://doi.org/10.1021/jo00986a004research-articleACS PublicationsRequest reuse permissionsArticle Views300Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficient image dataset classification difficulty estimation for predicting deep-learning accuracy (2020)

Abstract In the deep-learning community, new algorithms are published at a very fast pace. Therefore, solving an image classification problem for new datasets becomes a challenging task, as it requires to re-evaluate published algorithms and their different configurations in order to find a close to optimal classifier. To facilitate this process, before biasing our decision toward a class of neural networks or running an expensive search over the network space, we propose to estimate the classification difficulty of the dataset. Our method computes a single number that characterizes the dataset difficulty $$97\times $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>97</mml:mn><mml:mo>×</mml:mo></mml:mrow></mml:math> faster than training state-of-the-art networks. The proposed method can be used in combination with network topology and hyper-parameter search optimizers to efficiently drive the search toward promising neural network configurations.
A Mutant of Hepatitis B Virus X Protein (HBxΔ127) Promotes Cell Growth through A Positive Feedback Loop Involving 5-Lipoxygenase and Fatty Acid Synthase (2010)

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Hepatitis B virus X protein (HBx) contributes to the development of HCC, whereas HBx with COOH-terminal deletion is a frequent event in the HCC tissues. Previously, we identified a natural mutant of HBx-truncated 27 amino acids at the COOH-terminal (termed HBxDelta127), which strongly enhanced cell growth. In the present study, we focused on investigating the mechanism. Accordingly, fatty acid synthase (FAS) plays a crucial role in cancer cell survival and proliferation; thus, we examined the signaling pathways involving FAS. Our data showed that HBxDelta127 strongly increased the transcriptional activities of FAS in human hepatoma HepG2 and H7402 cells. Moreover, we found that 5-lipoxygenase (5-LOX) was responsible for the up-regulation of FAS by using MK886 (an inhibitor of 5-LOX) and 5-LOX small interfering RNA. We observed that HBxDelta127 could upregulate 5-LOX through phosphorylated extracellular signal-regulated protein kinases 1/2 and thus resulted in the increase of released leukotriene B4 (LTB4, a metabolite of 5-LOX) by ELISA. The additional LTB4 could upregulate the expression of FAS in the cells as well. Interestingly, we found that FAS was able to upregulate the expression of 5-LOX in a feedback manner by using cerulenin (an inhibitor of FAS). Collectively, HBxDelta127 promotes cell growth through a positive feedback loop involving 5-LOX and FAS, in which released LTB4 is involved in the up-regulation of FAS. Thus, our finding provides a new insight into the mechanism involving the promotion of cell growth mediated by HBxDelta127.
Primary Needle-Knife Sphincterotomy for Biliary Access in Patients at High Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis (2021)

NKS might be feasible as a primary cannulation procedure in patients at high risk of PEP. This trial is registered with KCT0004886 (03/06/2018).
Speech Bandwidth Extension: Extrapolations of Spectral Envelop and Harmonicity Quality of Excitation (2006)

This paper presents a method for restoration of the missing bandwidth of narrowband speech signals. Speech is decomposed into a linear prediction (LP) model of the spectral envelop and a harmonic plus noise model (HNM) of speech excitation. The LP spectral envelope and HNM excitation parameters of the narrowband speech are extrapolated using codebooks trained on narrowband and wideband speech. A novel contribution of this paper is the introduction of a parametric measure of the harmonicity of excitation in harmonically-spaced sub-bands. The wideband LSF parameters and the degree of harmonicity of missing excitation are estimated from those of the narrowband speech via codebook mapping. The method is successful in restoring the harmonicity of speech and converts telephone quality speech to perceptually high quality wideband speech.
Analysis of Acousto-Electromagnetic Scattering from a Dielectric Cylinder using the Finite-Difference Time-Domain Method (2006)

Analytical solutions for the Doppler component have been obtained for infinite, circular dielectric and metallic cylinders. However, in order for the approach to be of practical significance, the capability to analyze arbitrary scatterers needs to be developed. Previously, the portion of the Doppler component arising from boundary perturbation has been modelled using sheet boundary conditions (SBC) and the finite-difference time-domain (FDTD) method in two dimensions. To complete the two-dimensional model, the portion of the Doppler component due to dielectric modulation is now presented. The results are compared with the analytical solutions for circular cylinders