gebhart/patrepeval huggingface dataset:
Three principal results from recent Fenton Hill flow testing (1997)

Results of recent flow testing at Fenton Hill, New Mexico, have been examined in light of their applicability to the development of commercial-scale hot dry rock (HDR) reservoirs at other sites. These test results, obtained during the cumulative 11 months of reservoir flow testing between 1992 ad 1995, show that rhere was no significant production temperame drawdown during this time and that the reservoir flow became more dispersed as flow testing pmaxded. Based on these test results together with previous HDR research at Fenton Hill ard elsewhere, it is concluded that a three-well geometry, with one centrally located injection well and two production wells-- one at each end of the pssure stimulated reservoir region-- would provide a much more productive system for f u m e HDR development than the two-well system tested at
ChemInform Abstract: TESTOSTERONE FROM 4‐ANDROSTENE‐3,17‐DIONE BY DIISOBUTYLALUMINUM HYDRIDE REDUCTION AND SELECTIVE ′IN SITU′ OPPENAUER OXIDATION (1976)

Abstract In einem Eintopfverfahren ist die Titelverbindung (II) durch Reduktion des Androstendions (I) mit Diisobutyl‐Alhydrid und darauffolgende Zugabe von Isopropano1/ Aceton für die selektive Oppenauer‐Oxidation des intermediären O,O′‐Bis‐[diisobutyl‐A1]‐Derivats darstellbar.
A method of assessing the efficacy of memory rehabilitation techniques using a "real-world" memory task: Learning a computer language (1991)

A software program developed to assess the effectiveness of memory rehabilitation techniques is described. This project addresses current weaknesses in the research literature on memory rehabilitation: 1) remediation strategies are evaluated in terms of performance on a practical, real-world memory task, rather than a laboratory learning task; 2) the program allows maximum flexibility in assessing a wide variety of remediation strategies and training schedules; and, 3) the software, which provides sensitive outcome measures and detailed feedback about performance, is adaptable to the needs of patients with widely varying degrees of memory impairment. The results of a demonstration project are included to illustrate the use of this technology in determining the usefulness of different mnemonic strategies for patients with specific patterns of memory deficit. The importance of assessing maintenance of rehabilitation training over time is stressed.
Preparation of new electrolytic capacitor anode of niobium suboxide (2005)

The preparation of niobium suboxide by Mg reduction procedure, high energy ball milling procedure and Nb reduction Nb_2O_5 procedure was introduced, respectively. The Mg reduction procedure is difficult to control, and the production phase is complex, with comparatively coarse particle size and simpleness granule figure. The specific capacity is smaller, and the loss is higher than that of anodes prepared by two other processes. The particle size of production of high energy ball milling procedure is fine, and its specific capacity is 107mF·V/g. Induction of impurity results in higher leak current. The electrical property of Nb suboxide of preparation by Nb reduction Nb_2O_5 procedure is eximious. The specific capacity is 69.5mF·V/g, the loss is 11.25%, leakage current (K) is 1.8×10~(-4) μA/(μF·V), and its electrical properties are better than those of the national standard of FTa16-300 tantalum powder for capacitor.
[Development of bacteriophage Mu in E. coli gyrBts mutant strain]. (1985)

The study deals with Mu growth in cells carrying a temperature-sensitive mutation in the gene of DNA gyrase B subunit. At a nonpermissive temperature the Mu growth is shown to be blocked in the host gyrB ts mutant both on infection and on prophage induction. Mu DNA does not get integrated in the host chromosome upon the infection of mutant cells, as demonstrated by DNA-DNA hybridization experiments. In the case of prophage induction in mutant cells, as opposed to the wild type cells early mRNA synthesis is practically fully inhibited while the total RNA synthesis is three times reduced after 20 min of induction. The transcription of phage DNA associated with the changed superhelicity of DNA in the cell.
Approaches to General Education: National, State and Institutional Perspectives in the United States (2005)

This research paper provides an overview of some trends in general education reform from international, national, and institutional levels and explores institutional strategies to facilitate the shift to general education. Eventually, through benchmarking and a comparative perspective, this article intends to provide a framework for academic planners to analyze and integrate various approaches to general education.
Dermatite seborreica (2011)

Seborrheic dermatitis is a chronic relapsing erythematous scaly skin disease, the prevalence of which is around 1 to 3% of the general population in the United States. It has two incidence peaks, the first in the first three months of life and the second beginning at puberty and reaching its apex at 40 to 60 years of age. The prevalence of seborrheic dermatitis is higher in HIV-positive individuals and the condition tends to be more intense and refractory to treatment in these patients. Neurological disorders and other chronic diseases are also associated with the onset of seborrheic dermatitis. The currently accepted theory on the pathogenesis of this disease advocates that yeast of Malassezia spp., present on the skin surface of susceptible individuals, leads to a non-immunogenic irritation due to the production of unsaturated fatty acids deposited on the skin surface. This article provides a review of the literature on seborrheic dermatitis, focusing on immunogenetics, the clinical forms of the disease and its treatment.
Effect of Indocyanine Green and Illumination on Gene Expression in Human Retinal Pigment Epithelial Cells (2003)

purpose. To investigate the biological effects of indocyanine green (ICG) and acute illumination on human retinal pigment epithelial (RPE) cells. methods. Three concentrations (0, 0.25, and 2.5 mg/mL) of ICG were applied to ARPE19 cells for 1 minute. After isotonic rinsing, the cells were irradiated with a light beam with a wavelength spectrum from 400 to 800 nm and an output of 1850 lumens for 15 minutes. The cells were collected at timed intervals for the investigation of cell death and expression of stress-response genes by reverse transcription-polymerase chain reaction, immunofluorescence, and Western blot analysis. results. After ICG incubation, photoreactive changes were observed in the RPE cells. A reduction in cellular viability and considerable shrinkage of the cells were observed. The expressions of the apoptosis-related genes p53 and bax and the cell cycle arrest protein p21 were upregulated in cells treated with both ICG and light. Of the early-response genes, the expression of c-fos was specifically enhanced by light, with additive effects from the presence of ICG. Such stimulatory effects on these gene expressions were greater at 2.5 mg/mL than at 0.25 mg/mL ICG. conclusions. ICG in the presence of acute illumination can elicit cell-cycle arrest and even apoptosis in RPE cells. The establishment of a safety level in the application of ICG in the region of 0.25 mg/mL is recommended.
Computed tomographic reconstruction based on x-ray refraction contrast (2005)

Computed tomographic (CT) reconstruction technique is widely used in many fields of research. Commonly the CT-reconstruction is based on the x-ray absorption contrast. However, recently, methods for generating other x-ray contrasts have been developed. One of them is the refraction contrast which provides information on the deflection of the x-ray beam when penetrating through the object. This contrast has certain advantages and allows us to observe details invisible in the absorption images. Thus, CT based on the refraction contrast must have the same advantages. However, it requires a new mathematical algorithm and software. This letter is dedicated to the solution of the problem including theoretical consideration on the mathematical model which is the basis for the computer modeling and experimental realization of the technique. Actual experimental results together with the reconstructed images are presented and described.
Bapineuzumab for mild to moderate Alzheimer’s disease in two global, randomized, phase 3 trials (2016)

Noncarriers (3000) ClinicalTrials.gov identifier NCT00667810 ; registered 24 Apr 2008. Carriers (3001) ClinicalTrials.gov identifier NCT00676143 ; registered 2 May 2008.
Further Characterization of Complement Regulator-Acquiring Surface Proteins of<i>Borrelia burgdorferi</i> (2001)

The three genospecies Borrelia burgdorferi, Borrelia garinii, and Borrelia afzelii, all causative agents of Lyme disease, differ in their susceptibilities to human complement-mediated lysis. We recently reported that serum resistance of borrelias correlates largely with their ability to bind the human complement regulators FHL-1/reconectin and factor H. To date, two complement regulator-acquiring-proteins (CRASP-1 and CRASP-2) have been identified in serum-resistant B. afzelii isolates (P. Kraiczy, C. Skerka, M. Kirschfink, V. Brade, and P. F. Zipfel, Eur. J. Immunol. 31:1674-1684, 2001). Here, we present a comprehensive study of the CRASPs detectable in both serum-resistant and intermediate serum-sensitive B. afzelii and B. burgdorferi isolates. These CRASPs were designated according to the genospecies either as BaCRASPs, when derived from B. afzelii, or as BbCRASPs, for proteins identified in B. burgdorferi isolates. Each borrelial isolate expresses distinct CRASPs that can be differentiated by their mobility and binding phenotypes. A detailed comparison reveals overlapping and even identical binding profiles for BaCRASP-1 (27.5 kDa), BbCRASP-1 (25.9 kDa), and BbCRASP-2 (23.2 kDa), which bind FHL-1/reconectin strongly and interact weakly with factor H. In contrast, two B. afzelii proteins (BaCRASP-4 [19.2 kDa] and BaCRASP-5 [22.5 kDa]) and three B. burgdorferi proteins (BbCRASP-3 [19.8 kDa], BbCRASP-4 [18.5 kDa], and BbCRASP-5 [17.7 kDa]) bind factor H but not FHL-1/reconectin. Most CRASPs bind both human immune regulators at their C-terminal ends. Temperature-dependent up-regulation of CRASPs (BaCRASP-1, BaCRASP-2, and BaCRASP-5) is detected in low-passage borrelias cultured at 33 or 37 degrees C compared with those cultured at 20 degrees C. The characterization of the individual CRASPs on the molecular level is expected to identify new virulence factors and potential vaccine candidates.
Construction of Disarmed Ti Plasmids Transferable between <i>Escherichia coli</i> and <i>Agrobacterium</i> Species (2009)

Agrobacterium-mediated plant transformation has been used widely, but there are plants that are recalcitrant to this type of transformation. This transformation method uses bacterial strains harboring a modified tumor-inducing (Ti) plasmid that lacks the transfer DNA (T-DNA) region (disarmed Ti plasmid). It is desirable to develop strains that can broaden the host range. A large number of Agrobacterium strains have not been tested yet to determine whether they can be used in transformation. In order to improve the disarming method and to obtain strains disarmed and ready for the plant transformation test, we developed a simple scheme to make certain Ti plasmids disarmed and simultaneously maintainable in Escherichia coli and mobilizable between E. coli and Agrobacterium. To establish the scheme in nopaline-type Ti plasmids, a neighboring segment to the left of the left border sequence, a neighboring segment to the right of the right border sequence of pTi-SAKURA, a cassette harboring the pSC101 replication gene between these two segments, the broad-host-range IncP-type oriT, and the gentamicin resistance gene were inserted into a suicide-type sacB-containing vector. Replacement of T-DNA with the cassette in pTiC58 and pTi-SAKURA occurred at a high frequency and with high accuracy when the tool plasmid was used. We confirmed that there was stable maintenance of the modified Ti plasmids in E. coli strain S17-1lambdapir and conjugal transfer from E. coli to Ti-less Agrobacterium strains and that the reconstituted Agrobacterium strains were competent to transfer DNA into plant cells. As the modified plasmid delivery system was simple and efficient, conversion of strains to the disarmed type was easy and should be applicable in studies to screen for useful strains.
Karnofsky performance status revisited: reliability, validity, and guidelines. (1984)

Little research has been conducted documenting the reliability and validity of the Karnofsky Performance Status (KPS) scale, and guidelines based on empirical data do not exist to govern its use. Two hundred ninety-three cancer patients completed a questionnaire that assesses their physical and psychosocial difficulties. Physicians rated patients on the KPS and a subsample of 75 patients was used to evaluate interrater reliability. Analyses were conducted to evaluate the interrater reliability and construct validity of the KPS. The KPS was shown to have good reliability and validity. Detailed examination of the reliability data suggested areas in which physicians err in their judgments. Multiple regression techniques were used to empirically identify seven behaviorally based questions that would be helpful in predicting KPS scores. The seven variables included weight loss, weight gain, reduced energy, difficulty walking, driving, grooming, and working part time. An interview approach with behaviorally based guidelines is presented using these variables to obtain relevant data and make more accurate KPS ratings. With the approach suggested and the guidelines presented, oncologists may train themselves to use the KPS in a standard way, which should increase reliability and validity of the KPS and has implications for patients and research studies that use KPS as a stratifying variable.
Nicotine‐induced neuroprotection against <i>N</i>‐methyl‐<scp>d</scp>‐aspartic acid or β‐amyloid peptide occur through independent mechanisms distinguished by pro‐inflammatory cytokines (2003)

Nicotine, the causative agent of addiction to tobacco, can also be a neuroprotectant. Nicotine-induced neuroprotection against different toxins is imparted through pharmacologically distinct neuronal nicotinic acetylcholine receptors (nAChR) where protection against chronic N-methyl-d-aspartic acid (NMDA) exposure is through nAChRalpha7 but protection against the toxic peptide of amyloid precursor protein, Abeta25-35, is through nAChRalpha4beta2. The inflammatory cytokine tumor necrosis factor alpha (TNFalpha) is also neuroprotective, however, in the presence of nicotine, neuroprotection against NMDA is abolished. The specificity of nicotine-TNFalpha antagonism was further refined using a mouse transgenic dominant negative of nAChRalpha7 in which nicotine failed to induce neuroprotection against NMDA and antagonism of TNFalpha was absent. However, nicotine-mediated neuroprotection against Abeta25-35 was unaffected and, therefore, did not require the expression of functional nAChRalpha7s. The mechanism of TNFalpha-mediated neuroprotection and antagonism by nicotine was independent of caspase 8 activation or nuclear factor kappa B translocation in neurons but C6-ceramide addition to neuronal cultures subsequently exposed to NMDA mimicked the neuroprotective effect of TNFalpha and, like TNFalpha, it was antagonized by cotreatment with nicotine. Therefore, the neuroprotective effects of nicotine against differing toxic assaults requires distinct nAChR subtypes and proceeds through intracellular pathways that overlap with similarly different mechanisms initiated by pro-inflammatory cytokines. These results provide insight into how nicotine imparts neuroprotection and modulates inflammatory responses.
Experimental validation of extended depth-of-field imaging via spherical coding (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text D. Robinson and V. Bhakta, "Experimental validation of extended depth-of-field imaging via spherical coding," in Frontiers in Optics 2009/Laser Science XXV/Fall 2009 OSA Optics & Photonics Technical Digest, OSA Technical Digest (CD) (Optica Publishing Group, 2009), paper CThB4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Special Feature A Qualitative Assessment of Parallelism in Expert Systems (1985)

Developers envision expert systems that can make up to one billion inferences per second. This will require full utilization of a system's potential for parallel processing.
Detecting denial of service attacks using database queries (2005)

In most current generation intrusion detection technology systems the output data are stored into flat files. By contrast, ease in storing, analyzing, categorizing, and accessing data are major advantages that accrue when using databases in hold intrusion detection data. Often, security analysts have to repeatedly perform the difficult task of sorting through a haystack of attack alerts, many of which turn out to be inaccurate. It is possible to make the job of managing these alerts, analyzing data with high precision, and searching for attacks or intrusions easier by using database query oriented analysis. This project was conducted in order to demonstrate, as proof of concept, the effectiveness in intrusion detection handling of intrusion data when writing them into a database system and analyzing them with SQL. A database plug-in was developed that deposits the data from an intrusion detection system to a database. Subsequently, statistical analysis was conducted, which showed that database query methods can be effective in detecting intrusions, while decreasing the challenge of the analysis of intrusions.
Buildup rates of the nuclear Overhauser effect measured by two-dimensional proton magnetic resonance spectroscopy: implications for studies of protein conformation (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBuildup rates of the nuclear Overhauser effect measured by two-dimensional proton magnetic resonance spectroscopy: implications for studies of protein conformationAnil Kumar, Gerhard Wagner, Richard R. Ernst, and Kurt WuethrichCite this: J. Am. Chem. Soc. 1981, 103, 13, 3654–3658Publication Date (Print):July 1, 1981Publication History Published online1 May 2002Published inissue 1 July 1981https://pubs.acs.org/doi/10.1021/ja00403a008https://doi.org/10.1021/ja00403a008research-articleACS PublicationsRequest reuse permissionsArticle Views1138Altmetric-Citations416LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Floral coloration and pigmentation in<i>Calibrachoa</i>cultivars (2004)

SummaryThe ¯oral pigment pro®les of twenty in Calibrachoa cultivars were determined and compared with the pro®les of selected Petunia cultivars. Calibrachoas could be divided into two groups based on high (177±871.mgg±1 FW) and low 2±9.mg g±1 FW) carotenoid content; the groups were represented by yellow and white ¯owers, respectively. In addition to yellow cultivars, the high carotenoid content group included vivid-red and vivid-purplish-red cultivars that were characterized by a low ¯oral pH of 4.5±4.8 and accumulation of delphinidin and petunidin, respectively, as the major ¯oral anthocyanidin. In addition to cultivars with white ¯owers, the low carotenoid content group contained vivid-purple and vivid-red-purple cultivars that were characterized by higher (pH 5.4±5.7) and intermediate (pH 4.8±5.3) corolla pHs, respectively, and accumulation of malvidin. The strategies of calibrachoas and petunias for expressing yellow and red ¯owers were found to differ. For yellow ¯owers, calibrachoas use carotenoids, whereas petunias use ¯avonols plus carotenoids. For red ¯owers, calibrachoas use carotenoids, delphinidin and lower corolla pH, whereas petunias use cyanidin and lower corolla pH.
Modeling deterministic chaos in gas-fluidized beds (1991)

Recent experimental studies at Oak National Laboratory and Morgantown Energy Technology Center suggest that the dynamics of gas-fluidized beds is dominated by deterministic chaos. In this paper we demonstrate that deterministic chaos in bubbling fluidized beds can arise readily from nonlinear bubble-to-bubble interactions. Using experimentally observed bubble interaction relationships, a simple one-dimensional model is constructed that exhibits the characteristics features of deterministic chaos. We show also that the dynamical behavior of this simple model is remarkably similar to experimentally observed voidage and pressure fluctuation patterns. Results from this preliminary study suggest specific directions for future fluidized-bed and applied chaos research. 12 refs., 5 figs.
Polyamides and their functionalization: recent concepts for their applications as biomaterials (2017)

Synthetic polyamides (nylons) are very important polymers with applications in many fields, and recently their use in biology and medicine has become more and more important. Different recent concepts and strategies for the functionalization and applications of nylons as biomaterials are summarized in this article, with a focus on their utilization as scaffolds for tissue engineering, membranes and bioactive surfaces.
Tetraphenylsilane derivatives spiro-annulated by triphenylamine/carbazole with enhanced HOMO energy levels and glass transition temperatures without lowering triplet energy: host materials for efficient blue phosphorescent OLEDs (2012)

Two new host materials, SiBSTPA and SiBSCz, were designed and synthesized based on 4,4′-bis(triphenylsilyl)-biphenyl (BSB). Their thermal, electrochemical, electronic absorption and photoluminescent properties were fully investigated. The introduction of spiro-annulated triphenylamine/carbazole moieties on 4,4′-bis(triphenylsilyl)-biphenyl (BSB) increases the HOMO energy levels from −6.49 eV (BSB) to −5.30 eV for SiBSTPA and −5.56 eV for SiBSCz, and accordingly facilitates hole injection from the nearby hole-transporting layer. Compared to 4,4′-bis(triphenylsilyl)-biphenyl (BSB), higher glass transition temperatures (Tg) were observed at 133 °C for SiBSTPA and 129 °C for SiBSCz, owing to the rigid spiro-annulated structures. Meanwhile, the perpendicular conformation between the triphenylamine or carbazole plane and the biphenyl plane effectively prevents the extension of the π-conjugation and consequently causes no depreciation of their triplet energies (ca. 2.75 eV). Phosphorescent organic light-emitting devices (PhOLEDs) with the following configuration: ITO/NPB/TCTA/EML/TAZ/LiF/Al were fabricated by using the two host materials and the blue emitter bis[2-(4′,6′-difluorophenyl)pyridinato-N,C2′]iridium(III) picolate (FIrpic) as the guest. These devices exhibited good performance with the maximum current efficiency of 21.4 cd A−1 and the maximum power efficiency of 15.6 lm W−1.