gebhart/patrepeval huggingface dataset:
In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-alpha RNA in the central nervous system. (1994)

This study determined the distribution of in situ polymerase chain reaction (PCR)-amplified HIV-1 nucleic acids in the central nervous system (CNS). Amplified viral DNA was detected in each of the seven HIV-1-positive cases and in none of the seven negative controls. HIV-1 DNA was rarely detected with standard in situ hybridization, consistent with low levels of proviral DNA. In patients with minimal clinical and pathological CNS involvement, only rare HIV-1 DNA-positive perivascular microglial cells were noted. In patients with dementia, many infected neurons and astrocytes as well as microglial cells were detected. Severe disease was also characterized by the detection of tumor necrosis factor-alpha (TNF-alpha) mRNA and viral RNA by reverse transcription (RT) in situ PCR. These results suggest that HIV-1 commonly exists in the CNS in the asymptomatic patient and that progression is marked by a dramatic increase of the number of cells with HIV-1 DNA, including neurons and astrocytes, and a concomitant upregulation of both viral and TNF-alpha transcription.
Automated geometric modelling of textile structures (2012)

An automated approach (TexGen) for modeling the geometry of textile structures is presented. This model provides a generic approach to the description of yarn geometry and yarn interlacement for all types of weaving. One feature of this model is that the shape and size of the cross sections may change locally; this is exploited in the functions for interference correction, which modify the textile according to geometric considerations to avoid penetration of yarns. Another feature of this model is that it acts as a pre-processor for finite element simulations by generating a mesh, definition of contact, materials orientation and boundary conditions, thus providing an automatic procedure. This paper describes the modeling techniques, algorithms and concepts implemented in TexGen and examines the functionality of their implementation for a range of two-dimensional/three-dimensional commercial fabrics. Comparisons between the images of real fabrics and modeled fabric structures confirm that the software is capable of modeling sophisticated fabric architectures, including twisted yarns with varied yarn cross sections. Accurate input measurements of fabric geometry are critical for successful results. The paper also discusses directions for further development of the approach to overcome current limitations.
Computation of Local Fractal Dimension Values of the Human Cerebral Cortex (2014)

Objectives: The purpose of this paper is to describe a technique for computing the local fractal dimension of the human cerebral cortex as extracted from high-resolution magnetic resonance imaging scans. Methods: 3D models of the human cerebral cortex were extracted from high resolution magnetic resonance images of 10 healthy adult volunteers using FreeSurfer. The local fractal dimension of the cortex was computed using a custom-written cube-counting algorithm. The effect of constraining the maximum region size on the measured value of local fractal dimension was examined. A proof of principle was demonstrated by comparing an individual with Alzheimer’s disease to a healthy individual. Results: Local values of cortical fractal dimension can be obtained by constraining the size of the region over which the cube counting is performed. Cubic regions of intermediate size (30 × 30 × 30 mm) yielded a profile that demonstrated greater regional variability compared to smaller (15 × 15 × 15 mm) or larger (60 × 60 × 60 mm) region sizes. Conclusions: Local fractal dimension of the cerebral cortex is a novel measure that may yield additional, quantitative insight into the clinical meaning of cortical shape changes.
Interpreting the Macroeconomic Time Series Facts: The Effects of Monetary Policy (1992)

Existing theory and evidence on the effects of monetary policy are reviewed. Substantial room for disagreement among economists remains. New evidence, based on multivariate time series studies of several countries, is presented. While certain patterns in the data consistent with effective monetary policy are strikingly similar across countries, others, particularly the tendency of interest rate increases to predict high inflation, are harder to reconcile with effective monetary policy.
Preparation of (Ba, Sr)TiO<sub>3</sub> Thin Films by Chemical Vapor Deposition Using Liquid Sources (1994)

Thin films of (Ba, Sr)TiO 3 with high dielectric constant were prepared on Pt/SiO 2 /Si substrates of 6-inch-diameter by chemical vapor deposition using liquid sources. Ba(DPM) 2 and Sr(DPM) 2 dissolved into tetrahydrofuran were vaporized in a vaporizer at 523 K, and Ti(O-i-C 3 H 7 ) 4 was bubbled at 313 K. The mixture of the source vapors with O 2 and N 2 O was supplied to the reactor (10 Torr) at uniform velocities through a shower-type nozzle, which realized uniform profiles in the deposited film thickness and composition. The electrical properties are significantly influenced by the film composition, and the typical properties obtained for a 800-Å-thick film prepared at the substrate temperature of 823 K are an equivalent SiO 2 thickness t eq of 5.2 Å, a leakage current J L of 2.4× 10 -6 A/cm 2 (at 1.65 V), and a dielectric loss tan δ of 0.07.
2-Amino-2-deoxy-D-idose (D-Idosamine) and 2-Amino-2-deoxy-D-talose (D-Talosamine) (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-Amino-2-deoxy-D-idose (D-Idosamine) and 2-Amino-2-deoxy-D-talose (D-Talosamine)ROGER W. JEANLOZ, ZOFIA TARASIEJSKA GLAZER, and DOROTHY A. JEANLOZCite this: J. Org. Chem. 1961, 26, 2, 532–536Publication Date (Print):February 1, 1961Publication History Published online1 May 2002Published inissue 1 February 1961https://pubs.acs.org/doi/10.1021/jo01061a059https://doi.org/10.1021/jo01061a059research-articleACS PublicationsRequest reuse permissionsArticle Views135Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dynamic tomography with a priori information (2011)

We present "dynamic tomography" algorithms that allow for the high-resolution, time-resolved imaging of dynamic (i.e., continuously time evolving) complex systems at existing x-ray micro-CT facilities. The behavior of complex systems is constrained by the underlying physics. By exploiting a priori knowledge of the geometry of the physical process being studied to allow the use of sophisticated iterative reconstruction techniques that incorporate constraints, we improve on current frame rates by at least an order of magnitude. This allows time-resolved imaging of previously intractable processes, such as two-phase fluid flow. We present reconstructions from experimental data collected at the Australian National University x-ray micro-CT facility.
Recombinant Vaccinia Interleukin-2-Infected Tumor Cell Vaccines in Immunotherapy of Murine Colon Adenocarcinoma (1993)

A recombinant vaccinia virus (vCF13) containing and expressing the gene for human interleukin (IL)-2(vCF13) was compared to a recombinant vaccinia transfection control strain containing the LacZ gene at the same insertion site (vTFCLZ-1) for their ability to augment the immunogenicity of murine colon adenocarcinoma cell lines CT26 and CA51 in Balb/c mice. Both recombinant vaccinia strains abolished tumorigenicity of 10(5) CT26 or CA51 tumor cells. vCF13-infected tumor cells that secreted human IL-2 as measured by both CTLL-2 and enzyme-linked immunosorbent assays induced delay in tumorigenesis when administered in two weekly subcutaneous injections 1 week prior to challenge with 10(5) uninfected tumor cells. Although three of five vCF13-CT26 immunized mice developed tumors by day 14 after challenge, intralesional injection of these tumors with vCF13 induced rapid regression, whereas all five tumors that developed in vTFCLZ-1 immunized mice showed no response to intralesional vTFCLZ-1. These preliminary results provide support for the potential utility of recombinant vaccinia/IL-2 in tumor immunotherapy.
Residual stress in thin-film parylene-c (2003)

This paper reports the influence of thermal annealing on the residual stress in parylene-c thin-films on silicon. Although recently others have used the diaphragm bulge testing method to measure the residual stress in parylene, this is the first extensive study of residual stress in parylene using the load-deflection method and rotating tip strain gages. This paper supports the hypothesis that stress is relaxed in parylene-c films at elevated temperatures (>100/spl deg/C) and that thermal stress accounts for 90% of the residual stress in films that have undergone annealing at these elevated temperatures. It was found that this held true up to 180/spl deg/C which is above the glass transition temperature of the material.
Determination of K-R Curve for Steel Structure Hot-Rolled Thin Plates (2002)

Some materials exhibit a rising K-R curve, while the K-R curve for other materials is flat. The shape of the K-R curve depends on material behavior and, to a lesser extent, on the configuration of the cracked structure. The K-R curve for an ideally brittle material is flat because the surface energy is an invariant material property. However, the K-R curve can take on a variety of shapes when nonlinear material behavior accompanies fracture. Five different hot-rolled thin plates are tested to investigate K-R curve behavior. A special experimental apparatus is used to prevent specimens from buckling.
The Effects of Geomechanical Deformation on Seismic Monitoring of CO2 Sequestration (2008)

When CO2 is injected into the subsurface, changes in pore pressure may lead to deformation of both the reservoir and the subsurface. Of concern is that this deformation may create or reactivate fracture networks, providing pathways for CO2 to migrate away from the targeted zone. By coupling a commercial reservoir fluid flow simulator with a finite element geomechanical solver, we model the geomechanical effects of CO2 injection into a simple reservoir. In order to link deformation with changes in seismic observables, a stress dependent rock physics model is outlined and calibrated. We utilize this model to show how injection induced stress changes might be imaged using shear wave splitting.
Prediction of BAW resonator performance using experimental and numerical methods (2005)

Filters based upon bulk-acoustic-wave (BAW) resonators are attractive for a variety of RF applications. To satisfy the ambitious specifications and to facilitate a fast and cost economic design, we present an efficient simulation strategy combining different modeling approaches. First, a 1D transmission line model (Mason model) is used to construct the layer stack to meet the desired resonance frequencies and bandwidth. Second, the system of Newton's equation of motion and Maxwell's equations coupled by the piezoelectric effect is solved by FEM simulations. Thus, the lateral structure, e.g., a specific border region, can be designed to maximize the Q-value and to minimize the excitation of spurious modes. The theoretical predictions are excellently confirmed by electrical measurements and laser interferometry. Typical technological features, such as processing-related non-uniform thicknesses, and their impact on the resonance characteristics are analyzed by numerical simulations.
Constantèlos (Dèmètrios J.), Byzantine Philanthropy and Social Welfare (1969)

Janin Raymond. Constantelos (Demetrios J.), Byzantine Philanthropy and Social Welfare. In: Revue des etudes byzantines, tome 27, 1969. pp. 333-334.
Algorithm of mining sequential patterns for web personalization services (2009)

This paper focuses on the requirements of web personalization service for sequential patterns and sequential mining algorithms. Previous sequential mining algorithms treated sequential patterns uniformly, but individual patterns in sequences often have different importance weights. To solve this problem, we propose a new algorithm to identify weighted maximal frequent sequential patterns. First, frequency of frequent single items is used to calculate the weights of frequent sequences. Then, the frequent weighted sequence is defined, leading not only to the discovery of important maximal sequences, but the property of anti-monotony. Web usage mining has been used effectively to inform web personalization and recommender systems, and this new algorithm provides an effective method for optimizing these services. A variety of recommendation frameworks have been proposed previously, including some based on non-sequential models such as association rules, as well as sequential models. In this paper, we present a hybrid web personalization system based on clustering and contiguous sequential patterns. Our system clusters log files to determine the basic architecture of websites, and for each cluster, we use contiguous sequential pattern mining to further optimize the topologies of websites. Finally, we propose two evaluating parameters to test the performance of our system.
Capacitive Circuit Method for Fast and Efficient Design of Wideband Radar Absorbers (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A simple, fast and efficient method for designing wideband radar absorbers is proposed. The idea is to modify the circuit analog absorber method without perturbing the bandwidth. This is done by utilizing the asymptotic behavior of such an absorber at low frequency and replacing the band-stop resonating frequency selective surfaces with low-pass capacitive ones, which can be synthesized by square patches. It is shown that higher frequencies are not influenced by these modifications. A thin wideband capacitive circuit absorber (CCA) is presented with 28% reduction of thickness and 57% increase of bandwidth in comparison to the Salisbury screen. It is also explained why some optimized metamaterial designs fail to compete with the CCA method. For high permittivity layers, it is shown that the CCA is a better solution than the Jaumann absorber and improvements both in thickness and bandwidth are possible. A three layered ultrawideband CCA is presented with total thickness of 15.1 mm. </para>
Galectin-1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchyma (2001)

Protein (lectin)-carbohydrate interaction is supposed to be relevant for tumor cell behavior. The aims of the present work are to investigate whether galectin-1 modulates migration/invasion features in human gliomas in vitro, whether it can be detected in human gliomas immunohistochemically, and whether its expression is attributable to certain glioma subgroups with respect to invasion and prognosis. For this purpose, we quantitatively determined (by computer-assisted microscopy) the immunohistochemical expression of galectin-1 in 220 gliomas, including 151 astrocytic, 38 oligodendroglial, and 31 ependymal tumors obtained from surgical resection. We also xenografted three human glioblastoma cell lines (the H4, U87, and U373 models) into the brains of nude mice in order to characterize the in vivo galectin-1 expression pattern in relation to tumor invasion of the normal brain parenchyma. In addition, we characterized the role in vitro of galectin-1 in U373 tumor astrocyte migration and kinetics. Our data reveal expression of galectin-1 in all human glioma types with no striking differences between astrocytic, oligodendroglial, and ependymal tumors. The level of galectin-1 expression correlated with the grade in the group of astrocytic tumors only. Furthermore, immunopositivity of high-grade astrocytic tumors from patients with short-term survival periods was stronger than that of tumors from patients with long-term survivals. In human glioblastoma xenografts, galectin-1 was preferentially expressed in the more invasive parts of these xenografts. In vitro experiments revealed that galectin-1 stimulates migration of U373 astrocytes.
A complementary gain cell technology for sub-1 V supply DRAMs (1992)

A Complementary Gain (CG) cell concept is proposed and experimentally demonstrated to overcome the scaling limit of the conventional DRAM cell. The CG cell performance is described in comparison with a conventional cell from the viewpoint of factors relevant to gigabit integration, such as supply voltage scalability, minimum storage capacitance, immunity to noise on bitline and cell size. The test CG memory cell operation is successfully demonstrated at a supply voltage below 1V.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Guidelines for the Management of Spontaneous Intracerebral Hemorrhage (2010)

Intracerebral hemorrhage is a serious medical condition for which outcome can be impacted by early, aggressive care. The guidelines offer a framework for goal-directed treatment of the patient with intracerebral hemorrhage.
Detection of liver cells in peripheral blood of patients with advanced-stage hepatocellular carcinoma (1995)

A large percentage of patients with advanced-stage hepatocellular carcinoma (HCC) have a recurrence of tumor in the liver or lung after primary resection and even after orthotopic liver transplantation. One reason for this may be the presence of small numbers of tumor cells circulating in the blood before surgery or the liberation of tumor cells into circulation during surgical manipulation. We tested this hypothesis by measuring messenger RNA (mRNA) for human albumin gene as a liver cell marker with the highly sensitive reverse transcriptase polymerase chain reaction (RT-PCR) technique. Albumin mRNA was not found in peripheal blood from normal humans (0 of 6), from patients with liver cirrhosis (0 of 10), from other tumors metastatic to liver (0 of 10), or during liver transplant surgery for cirrhosis (0 of 10). In patients with advanced-stage HCC (TNM stages III and IV), albumin mRNA was detected (16 of 17) in peripheral blood. After liver transplantation in the HCC patients, the level of mRNA decreased below the detectable limit (0 of 9). Three of these patients again had detectable mRNA levels when they had recurrence of HCC after liver transplantation. Patients with stage I HCC did not have detectable expression. These results suggest that circulating tumor cells are present in patients with advanced-stage HCC, which may be one of the reasons why these patients have a high incidence of tumor recurrence after apparently definitive surgical resection and even after liver transplantation. (Hepatology 1995;21:403-407.)
MSMExplorer: visualizing Markov state models for biomolecule folding simulations (2013)

MSMExplorer is available for download from https://simtk.org/home/msmexplorer. The source code is made available under the GNU Lesser General Public License at https://github.com/SimTk/msmexplorer.
Résiliation du bail commercial et modification des prétentions des parties (2009)

International audience
Zika Virus Infection in Pregnant Women in Rio de Janeiro (2016)

Despite mild clinical symptoms in the mother, ZIKV infection during pregnancy is deleterious to the fetus and is associated with fetal death, fetal growth restriction, and a spectrum of central nervous system abnormalities. (Funded by Ministério da Saúde do Brasil and others.).
Light in Relation to the Experimental Modification of the Breeding Season of Turkeys (1937)

AMONG the domesticated farm birds, the reproductive cycle of the turkey bears the most striking similarity to that of birds in the wild state. The turkey is therefore, very favorable material for studies relating to the experimental modification of the breeding season. Sexual periodicity is fixed from year to year among wild birds although climatic conditions may fluctuate widely with respect to inception and severity. The incidence of daylight and darkness is, however, the most constant of the environmetal factors. These facts led Schäfer (1907) to conclude that the length of the day influences the sex-cycle of birds. Rowan (1928) concluded that sexually inactive juncos could be made sexually active by forced muscular work. Bissonnette (1930), however, failed to activate the germinal elements of the starling’s testes by induced muscular work during the months of December and January when they are normally quiescent. Irradiation, however, with a 60-watt incandescent bulb . . .
Immune Responses Regulated by Cannabidiol (2019)

<b>Introduction:</b> Cannabidiol (CBD) as Epidiolex<sup>®</sup> (GW Pharmaceuticals) was recently approved by the U.S. Food and Drug Administration (FDA) to treat rare forms of epilepsy in patients 2 years of age and older. Together with the increased societal acceptance of recreational cannabis and CBD oil for putative medical use in many states, the exposure to CBD is increasing, even though all of its biological effects are not understood. Once such example is the ability of CBD to be anti-inflammatory and immune suppressive, so the purpose of this review is to summarize effects and mechanisms of CBD in the immune system. It includes a consideration of reports identifying receptors through which CBD acts, since the "CBD receptor," if a single one exists, has not been definitively identified for the myriad immune system effects. The review then provides a summary of <i>in vivo</i> and <i>in vitro</i> effects in the immune system, in autoimmune models, with a focus on experimental autoimmune encephalomyelitis, and ends with identification of knowledge gaps. <b>Conclusion:</b> Overall, the data overwhelmingly support the notion that CBD is immune suppressive and that the mechanisms involve direct suppression of activation of various immune cell types, induction of apoptosis, and promotion of regulatory cells, which, in turn, control other immune cell targets.
System design, test results, and economic analysis of a flywheel energy storage and conversion system for photovoltaic applications (1980)

MIT Lincoln Laboratory is developing a flywheel interface and storage system for use with photovoltaic power sources. Test data on the performance of components built to investigate the feasibility of such a system, and the results of economic studies of the system showing user-worth analysis and manufacturing-cost estimates, are presented. The system has magnetic bearings, a maximum-power-point tracker, DC input, and cycloconverter output from an ironless-armature motor-generator.
Further delineation of Loeys-Dietz syndrome type 4 in a family with mild vascular involvement and a TGFB2 splicing mutation (2014)

Our data confirm that loss-of-function mutations in TGFB2 gene do not always lead to aggressive vascular phenotypes and that articular and skeletal signs are prevalent, therefore suggesting that LDS4 must be considered in patients with sparse signs of LDS and related disorders also in the absence of vascular events.