gebhart/patrepeval huggingface dataset:
HMB‐45 recognizes stimulated melanocytes (1989)

A monoclonal antibody (HMB-45) was previously reported to bind to melanoma cells, and the junctional component of nevus cells, but not to normal adult melanocytes. We have tested HMB-45 binding in several conditions under which melanocyte stimulation might be expected in adults, i.e. 3 simple lentigines, 2 solar lentigines, 7 recent surgical scars (from re-excision of non-melanocytic tumors), 2 surgical scars from re-excisions of melanomas (after complete primary excisions), 9 hemangiomas from non-sun-exposed skin, 1 basal cell carcinoma, 1 acute ecchymosis, 1 keloid, and 1 dermatofibroma. Positive controls included 6 malignant melanomas and 1 fetal skin sample. Melanocytes were strongly positively stained overlying hemangiomas, within or near recent surgical scars of melanocytic and non-melanocytic tumor re-excisions, near basal cell carcinoma, and in fetal skin. Melanocytes either were not stained or were stained only focally for trace amounts in the normal skin near the new margins of the wide re-excision specimens for melanoma, i.e., at a distance from the scar, in the simple lentigines and in the fibrotic lesions. Thus, HMB-45 is staining an antigen which appears in adult melanocytes during stimulation and in fetal skin, as well as in melanomas. This stimulation is associated with conditions that would have increased vascularity, suggesting a melanocyte response to a plasma factor, or other endothelial cell derived factor. HMB-45 would not be a useful marker for residual melanoma cells in melanoma re-excision specimens.
The autoimmune response of different mouse strains to T-cell epitopes of the human acetylcholine receptor alpha subunit. (1990)

The specific recognition of the acetylcholine receptor and its alpha-subunit by T cells derived from patients with myasthenia gravis or mice with experimental autoimmune myasthenia gravis raises the question of the role of autoreactive T cells in the myasthenic process. Sequences of the acetylcholine receptor alpha-subunit previously shown to be immunogenic in myasthenic patients were tested for their immunogenicity in various inbred mouse strains. High, intermediate and low T-cell proliferative responses could be observed to peptides representing sequences 195-212 and 259-271 of the human acetylcholine receptor alpha-subunit. Following immunization with the Torpedo acetylcholine receptor, lymphocytes of SJL mice proliferated efficiently to p 195-212 but not to p259-271. On the other hand, lymph node cells of BALB/c mice responded well to p259-271 but not to p195-212. Thus, the influence of the genetic make-up of the examined mice on the immune response to the two peptides could be clearly demonstrated by the existence of strain-dependent immunodominant and cryptic regions on the autoantigen. The differences between the strains were less pronounced when antibody responses were measured to these two T-cell epitopes, although a partial correlation with the proliferative responses could be observed. It can be concluded that epitopes specifically recognized by T lymphocytes of patients with myasthenia gravis also represent specific T-cell epitopes in the autoreactivity to the acetylcholine receptor in mice and that immune responsiveness to these peptides is influenced by the genetic make-up of the responding mouse strains.
The intersection of pop culture and non-traditional sports: an examination of the niche market of quidditch (2012)

The real sport of quidditch was recently adapted from the fictional sport of the same namesake in the Harry Potter (HP) franchise. Quidditch is played at hundreds of locations across the USA and around the world. Considering the lack of marketing research on non-traditional, co-ed sports and the innovative nature of quidditch, the purpose of this research was to conduct a qualitative, grounded theory study (Strauss and Corbin, 1990) on the athletes and determine how involvement and identification is associated with these individuals becoming a viable niche market within the sports industry. Five factors led towards a desire to partake in quidditch and become involved and identified with the sport: identification with Harry Potter, camaraderie and friendship, desire to have fun, desire to try something new, and desire to get in shape.
ETHYLENEUREA. II. SYNTHESES FROM ETHYLENE GLYCOL OR ETHANOLAMINE AND UREA (OR CARBON DIOXIDE AND AMMONIA) (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTETHYLENEUREA. II. SYNTHESES FROM ETHYLENE GLYCOL OR ETHANOLAMINE AND UREA (OR CARBON DIOXIDE AND AMMONIA)CARL E. SCHWEITZERCite this: J. Org. Chem. 1950, 15, 3, 475–480Publication Date (Print):May 1, 1950Publication History Published online1 May 2002Published inissue 1 May 1950https://pubs.acs.org/doi/10.1021/jo01149a006https://doi.org/10.1021/jo01149a006research-articleACS PublicationsRequest reuse permissionsArticle Views266Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interactive interpretation of seismic data (1984)

Abstract This paper describes the use of an interactive system that displays seismic data in color on a television screen. The system is easy to use and, by automatically managing the data base for the interpreter, permits him to spend a larger portion of his time on the interpretation itself. A 3-D data volume can be studied in both vertical or horizontal section form. The system can equally well handle the irregular grid from a 2-D survey. In the course of interpreting a section on the screen, the interpreter may manipulate portions of that section in a variety of ways. He may make composite displays of multiple pieces of data, track horizons in automatic or manual modes, and zoom portions of the data to any desired extent. An interpretation made on one section can later be viewed on other sections marked at the points of intersection. Data can also be flattened to aid in structural and stratigraphic interpretations. Working maps can be produced at any time to check the progress of the interpretation. Final maps can be smoothed and manipulated to yield isochron, isopach, and other map products.--Modified journal abstract.
Waste Water Treatment Using Eco Friendly Oxidising Agent Fe (VI) (2011)

Ferrate (Fe (VI)) is a potential water treatment chemical due to its dual functions as an oxidant and a subsequent coagulant/precipitant as ferric hydroxide. Hence, an application of Fe (VI) to wastewater could achieve both oxidative elimination of various micro pollutants and reduction in the COD, BOD, Total hardness, Chloride, Fluoride can be achieved.
Feature selection for trainable multilingual broadcast news segmentation (2004)

Indexing and retrieving broadcast news stories within a large collection requires automatic detection of story boundaries. This video news story segmentation can use a wide range of audio, language, video, and image features. In this paper, we investigate the correlation between automatically-derived multimodal features and story boundaries in seven different broadcast news sources in three languages. We identify several features that are important for all seven sources analyzed, and we discuss the contributions of other features that are important for a subset of the seven sources.
Design, Implementation and Validation of a GNSS Measurement Exclusion and Weighting Function with a Dual Polarized Antenna (2018)

Global Navigation Satellite Systems (GNSSs) have become a ubiquitous tool for our modern society to carry out vital tasks such as transportation, civil engineering or precision agriculture. This breath has reached the realm of safety-critical applications such as time management of critical infrastructures or autonomous vehicles, in which GNSS is an essential tool nowadays. Unfortunately, current GNSS performance is not enough to fulfill the requirements of these professional and critical applications. For this reason, the FANTASTIC project was launched to boost the adoption of these applications. The project was funded by the European GNSS agency (GSA) in order to enhance the robustness and accuracy of GNSS in harsh environments. This paper presents the part related to the development of a weighting and exclusion function with a dual circularly polarized antenna. The idea is to reduce the effects of multipath by weighting and/or excluding those measurements affected by multipath. The observables and other metrics obtained from a dual polarized antenna will be exploited to define an exclusion threshold and to provide the weights. Real-world experiments will show the improvement in the positioning solution, using all available constellations, obtained with the developed technique.
Today’s Task for Economists (1993)

Recently, I have been left aghast by the placid acceptance of many economists close to the seats of power to remain content with modest palliative measures. They appeared constrained, I assume, by a need to reduce the so-called budget deficit, if not immediately, then in some future state of affairs, usually to a state of balance. Less actively articulated was a possibly more justified fear of rekindling inflation. What is urgently needed is to bring the economy rapidly to a point of genuine full employment and to keep it there. I define genuine full employment as a situation where there are at least as many job openings as there are persons seeking employment, probably calling for a rate of unemployment, as currently measured, of between 1 and 2 percent. Practically, the desirable situation ought be one in which any reasonably responsible person willing to accept available employment can find a job paying a living wage within 48 hours. Full employment, as delineated above, would have salutary consequences for levels of production, would reduce budgetary drains for unemployment insurance benefits, welfare payments and the like, and would have a significant impact on levels of poverty, homelessness, drug addiction, and crime. It would also substantially ease tensions over such issues as defense cutbacks, race relations, free trade, and immigration, as well as over many labor-management issues such as featherbedding, demarcation, seniority, and job tenure. Genuine full employment would allow qualified workers to move vertically out of low-skill jobs to jobs more suited to their potential. Under present conditions, training programs, though micro-effective in moving the selected trainees to the head of the queue, are nevertheless largely macro-ineffective in reducing the size of the queue. With full employment, training programs would gain effectuality at increasing overall productivity. This vertical movement of potentially qualified labor out of the low-skill market would in turn
Highly Efficient One-Pot Access to Functionalized Arylboronic Acids via Noncryogenic Bromine/Magnesium Exchanges (2011)

A general and convenient protocol for the electrophilic borylation of aryl Grignard reagents prepared from arylbromides by direct insertion of magnesium in the presence of LiCl or by Mg/Br exchange with (i)PrMgCl·LiCl has been developed. Various aryl boronic acids were synthesized in a straightforward manner in excellent yields at 0 °C.
Photosynthetically-Competent Phytoplankton from the Aphotic Zone of the Deep Ocean (1983)

Comparison of 2 water samples, one collected from 10 m, the other from the aphotic zone (1000 m) on the Costa Rica Dome in the eastern tropical Pacific Ocean, revealed the presence in both samples of pigmented cells of several diatoms, dinoflagellates and coccoid organisms. Measurements of carbon assimilation rates in temperature-controlled incubators across a light gradlent demonstrated that the assimilation number (mg C [mg Chl a]-' h-') of the 1000 m sample was about 0.8, slmilar to that of the 10 m sample. The ratios of RuBP carboxylase to other carboxylating enzymes were also similar between 10 m and the aphotic zone. However, the initial slope a and the inhlbltion parameter P were considerably higher for the deep sample than for the 10 m sample. Possible mechanisms by which these viable algae reached the aphotic zone are discussed.
FDA Approval Summary: Olaparib Monotherapy in Patients with Deleterious Germline <i>BRCA</i>-Mutated Advanced Ovarian Cancer Treated with Three or More Lines of Chemotherapy (2015)

On December 19, 2014, the FDA approved olaparib capsules (Lynparza; AstraZeneca) for the treatment of patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm) advanced ovarian cancer who have been treated with three or more prior lines of chemotherapy. The BRACAnalysis CDx (Myriad Genetic Laboratories, Inc.) was approved concurrently. An international multicenter, single-arm trial enrolled 137 patients with measurable gBRCAm-associated ovarian cancer treated with three or more prior lines of chemotherapy. Patients received olaparib at a dose of 400 mg by mouth twice daily until disease progression or unacceptable toxicity. The objective response rate (ORR) was 34% with median response duration of 7.9 months in this cohort. The most common adverse reactions (≥20%) in patients treated with olaparib were anemia, nausea, fatigue (including asthenia), vomiting, diarrhea, dysgeusia, dyspepsia, headache, decreased appetite, nasopharyngitis/pharyngitis/upper respiratory infection, cough, arthralgia/musculoskeletal pain, myalgia, back pain, dermatitis/rash, and abdominal pain/discomfort. Myelodysplatic syndrome and/or acute myeloid leukemia occurred in 2% of the patients enrolled on this trial.
Real-Time Detection and Understanding of Isolated Protruded Fingers (2005)

Making sense of hand gestures in applications such as novel user interfaces is an active area of research. Many current methods use complex 3D model of non-rigid hands and involved paradigms in solving the general problem. In this paper we look at a subproblem of sign language alphabet recognition where gestures are made with protruded fingers. In contrast to the more intricate schemes, we propose a simple, fast classification algorithm using two dimensional projection of Euler angles. Not only is our scheme novel, it lends itself to a real time implementation.
Advances in solid state photon detectors (2009)

Semiconductor photodiodes were developed in the early 'Forties approximately at the time when the photomultiplier tube became a commercial product (RCA 1939). Only in recent years, with the invention of the Geiger-mode avalanche photodiodes, have the semiconductor photo detectors reached sensitivity comparable to that of photomultiplier tubes. The evolution started in the 'Sixties with the p-i-n (PIN) photodiode, a very successful device, which is still used in many detectors for high energy physics and a large number of other applications like radiation detection and medical imaging. The next step was the development of the avalanche photodiode (APD) leading to a substantial reduction of noise but not yet achieving single photon response.<br />The weakest light flashes that can be detected by the PIN diode need to contain several hundreds of photons. An improvement of the sensitivity by 2 orders of magnitude was achieved by the development of the avalanche photodiode, a device with internal gain. At the end of the millennium, the semiconductor detectors evolved with the Geiger-mode avalanche photodiode into highly sensitive devices, which have an internal gain comparable to the gain of photomultiplier tubes and a response to single photons. A review of the semiconductor photo detector design and development, the properties and problems, some applications and a speculative outlook on the future evolution will be presented.
Soft tissue augmentation in dermatology - 2009 update (2010)

The number of products available to dermatologists for soft tissue augmentation has grown significantly over the past several years in the US. This manuscript will review the various hyaluronic acid fillers and other Food and Drug Administration -approved products we are utilizing for our patients in the rejuvenation process. It is hoped that through this article clinicians will feel more comfortable using these products in their everyday practice of dermatology.
Low Power Compact Design of ARIA Block Cipher (2006)

This paper presents a 32-bit hardware architecture reduced from the original 128-bit ARIA cryptographic algorithm. The hardware design in this paper is a low-power and compact version of ARIA for mobile environment. We use four S-boxes and modify a diffusion function and its data-path to reduce a hardware size. The proposed 32-bit ARIA needs 63 clock cycles to generate initial values for a round key and 356 clock cycles to encrypt a single message packet. The 32-bit ARIA has 13,893 gates. It is 62.5 % smaller than the original 128-bit ARIA. The power consumption is 61.46mW, 9.7% of the 128-bit version at 71MHz.
Impulse and fast surge distribution of voltage in 11 kV industrial motor (2016)

Insulation failure in a large industrial motor stator winding can occur due to electrical stresses generated by transient over voltages. The voltage distribution in motor winding for transient wave of impulse type or steep fronted type is non-linear. Consequently some turns are more stressed than others. Thus there is a higher probability of failure of those turns which are highly stressed. Estimation of turn to turn and turn to ground voltages is done by considering motor system as an equivalent electrical network. The aim of this paper is to evaluate internal voltage distribution in the winding due to the changes in capacitance and self inductance as well as mutual inductances on voltage magnitude by the application of impulse voltage at HV terminal. In this paper one 11 kV industrial motor winding is modeled and simulated by Electro Magnetic Transient Program (EMTP). The voltage distribution along the first coil and inter turn voltage distribution is presented for incoming wave of standard and non-standard shapes.
Current advancements on Covid-19 potential treatments: Learning from literature review (2021)

The coronavirus disease hit the world in December 2019 in Wuhan, China. A lot of developments towards the treatment of the disease have risen but no therapy has been scientifically proven successful up to date. However, regardless of current vaccines under clinical trials, much attention has been brought to repurposing old drugs as thousands of studies discuss their potential effectiveness against COVID-19. The present review discusses recent advancements in possible novel treatment and preventive therapeutics that are in ongoing trials. All the reviewed therapeutics in this article, regardless of their promising outcomes on the treatment and prophylaxis of COVID-19, have demonstrated no support to their efficacy regardless of other therapeutics such as convalescent plasma which has shown some potentiality for use. However, all the discussed interventions need thorough drug repositioning and advanced trial levels for them to be proved ready for clinical use.
Sperm Proteomics: Road to Male Fertility and Contraception (2013)

Spermatozoa are highly specialized cells that can be easily obtained and purified. Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis. In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; therefore, they are very suitable for proteomic studies. Recently, the application of proteomic approaches such as the two-dimensional polyacrylamide gel electrophoresis, mass spectrometry, and differential in-gel electrophoresis has identified several sperm-specific proteins. These findings have provided a further understanding of protein functions involved in different sperm processes as well as of the differentiation of normal state from an abnormal one. In addition, studies on the sperm proteome have demonstrated the importance of spermatozoal posttranslational modifications and their ability to induce physiological changes responsible for fertilization. Large-scale proteomic studies to identify hundreds to thousands of sperm proteins will ultimately result in the development of novel biomarkers that may help to detect fertility, the state of complete contraception, and beyond. Eventually, these protein biomarkers will allow for a better diagnosis of sperm dysfunctions and aid in drug development. This paper reviews the recent scientific publications available from the PubMed database to address sperm proteomics and its potential application to characterize male fertility and contraception.
PC platform power distribution system-past application, today's challenge and future direction (1999)

Segments of the PC industry have gone through dramatic changes. The future is even more challenging. Centralized DC power distribution has been extensively applied in most PC platforms today. This paper addresses limitations with conventional PC power distribution. Some processor roadmaps anticipate that PC platform power distribution will be analyzed and discussed in detail in the next five to ten years. This paper discusses future development direction and some novel design approaches.
Calibration of the scales of areal surface topography measuring instruments: part 3. Resolution (2013)

Calibration of the scales of areal surface topography measuring instruments requires testing of the resolution. Several designs of artefact that allow testing of the resolution of such instruments are currently available; however, analysis methods need to be developed to provide comparable results. A novel method for determining the lateral resolution of areal surface topography measuring instruments is presented. The method uses a type ASP (star-shaped) material measure. To demonstrate the validity of the method, the resolution of a phase shifting interferometer was determined based on the ISO definition of the lateral period limit. Using the proposed method, the type ASP material measure, which is often used to judge qualitatively an instrument's resolution, can be used to quantitatively estimate the resolution of instruments using the topography data.