gebhart/patrepeval huggingface dataset:
Nucleotide sequence and cloning in Bacillus subtilis of the Bacillus stearothermophilus pleiotropic regulatory gene degT (1990)

The regulatory gene (degT) from Bacillus stearothermophilus NCA1503 which enhanced production of extracellular alkaline protease (Apr) was cloned in Bacillus subtilis with pTB53 as a vector. When B. subtilis MT-2 (Npr- [deficiency of neutral protease] Apr+) was transformed with the recombinant plasmid, pDT145, the plasmid carrier produced about three times more alkaline protease than did the wild-type strain. In contrast, when B. subtilis DB104 (Npr- Apr-) was used as a host, the transformant with pDT145 could not exhibit any protease activity. After construction of the deletion plasmids, DNA sequencing was done. A large open reading frame was found, and nucleotide sequence analysis showed that the degT gene was composed of 1,116 bases (372 amino acid residues, molecular weight of 41,244). A Shine-Dalgarno sequence was found nine bases upstream from the open reading frame. A B. subtilis strain carrying degT showed the following pleiotropic phenomena: (i) enhancement of production of extracellular enzymes such as alkaline protease and levansucrase, (ii) repression of autolysin activity, (iii) decrease of transformation efficiency for B. subtilis (competent cell procedure), (iv) altered control of sporulation, (v) loss of flagella, and (vi) abnormal cell division. When B. stearothermophilus SIC1 was transformed with the recombinant plasmid carrying degT, the transformants exhibited abnormal cell division. These phenomena are similar to those of the phenotypes of degSU(Hy) (hyperproduction), degQ(Hy), and degR mutants of B. subtilis. However, the amino acid sequence of the degT product (DegT) is different from those of the reported gene products. Furthermore, DegT includes a hydrophobic core region in the N-terminal portion (amino acid numbers 50 to 160), a consensus sequence for a DNA binding region (amino acid numbers 160 to 179), and a region homologous to transcription activator proteins (amino acid numbers 351 to 366). We discuss the possibility that the membrane protein DegT functions as a sensor protein and transfers the signal of environmental stimuli to the regulatory region of target genes to activate or repress transcription of the genes.
Compensation of Discontinuities in Planar Transmission Lines (1982)

Compensation of discontinuity reactance associated with steps, right-angled bends, and T-junctions in planar transmission lines has been carried out by removing appropriate triangular portions from the discontinuity configurations. A two-dimensional analysis using a Green's functions approach has been employed.
Invited Review: Structure and Composition of Basement Membranes and Other Basal Matrix Systems in Selected Invertebrates (1991)

Abstract Problems concerning terminology and relationships of basement membranes to extracellular matrices (ECMs) and connective tissue systems in invertebrates are discussed, and recommendations regarding nomenclature are presented. It is suggested to use ‘basal matrix’ as a comprehensive term for various basal ECM structures, and apply the term ‘basement membrane’ (BM) for a unique ECM structure that is fully resolved only by electron microscopy and as a general and descriptive word in both light microscopy, biochemistry and electron microscopy. When possible and relevant it is recommended to apply the subdivisions: ‘lamina lucida’, ‘lamina densa’ (= ‘basal lamina’) and ‘lamina fibroreticularis’ (sometimes missing). A brief and non‐technical account of the recent concepts of BM macromolecules and their assembly is given, based on mammalian models. Basement membranes probably first appeared in cnidarians, and from then on became obligatory ECM structures. It is emphasized that this event was crucial for evolution of the multicellular state, and for construction and morphogenesis of tissues and organs. Lower worms, such as turbellarians and nemertines, display the most varied and complex basal matrices. First, in annelids, complete correlation between BM structure and composition has been demonstrated, with isolation and consecutive localization of basement‐specific molecules such as, for example, collagen IV and laminin. Both in arthropods, especially insects, and echinoderms, the introduction of modern techniques corresponding to those used in mammalian BM research has now given equally valid results. An interesting and fundamental outcome of the reviewed work on invertebrate BMs is the realization of the early evolution of BM components. Macromolecules such as laminin, collagen IV and fibronectin are highly conserved, but with fine modulations, and in lower invertebrates they may exist without being assembled into true BM structures. Laminin and fibronectin are expressed with certainty in cnidarians, and fibronectin possibly already in sponges.
Classifying Natural Language Sentences for Policy (2012)

Organizations derive policies from a wide variety of sources, such business plans, laws, regulations, and contracts. However, an efficient process does not yet exist for quickly finding or automatically deriving policies from uncontrolled natural language sources. The goal of our research is to assure compliance with established policies by ensuring policies in existing natural language texts are discovered, appropriately represented, and implemented. We propose a tool-based process to parse natural language documents, learn which statements signify policy, and then generate appropriate policy representations. To evaluate the initial work on our process, we analyze four data use agreements for a particular project and classify sentences as to whether or not they pertain to policy, requirements, or neither. Our k-nearest neighbor classifier with a unique distance metric had a precision of 0.82 and a recall of 0.81, outperforming weighted random guess, which had a precision of 0.44 and a recall of 0.46. The initial results demonstrate the feasibility of classifying sentences for policy and we plan to continue this work to derive policy elements from the natural language text.
Utilisation of chickpea protein isolates for production of peptides with angiotensin I‐converting enzyme (ACE)‐inhibitory activity (2002)

Abstract Chickpea protein isolates and the protease alcalase were used for the production of protein hydrolysates that inhibit angiotensin I‐converting enzyme (ACE). The highest degree of inhibition was found in a hydrolysate obtained by 30 min of treatment with alcalase. This hydrolysate was used as starting material for the purification of ACE‐inhibitory peptides. After Biogel P2 gel filtration chromatography and HPLC C 18 reverse phase chromatography, four peptides with ACE‐inhibitory activity were purified. Two of them were competitive inhibitors of ACE, while the other two were uncompetitive inhibitors. These results show that chickpea proteins are a good source of ACE‐inhibitory peptides when hydrolysed with the protease alcalase. © 2002 Society of Chemical Industry
Divinatorins A−C, New Neoclerodane Diterpenoids from the Controlled Sage <i>Salvia </i><i>d</i><i>ivinorum</i> (2003)

Three new neoclerodane diterpenoids, divinatorins A-C (7-9), have been isolated from the leaves of Salvia divinorum. The compounds were identified by spectroscopic methods as derivatives of the antibiotic (-)-hardwickiic acid (10), which was also isolated, along with four other known terpenoids. Neither the crude extract nor 7-9 displayed antimicrobial activity.
El ozono estratosférico (2006)

El ozono estratosf erico adquiri o una enorme relevancia hace dos d ecadas a ra iz del descubri-miento de fuertes anomal ias sobre la Ant artida motivadas por gases de origen antropog enico.Desde esa fecha, la estratosfera se ha convertido en una de las l ineas de investigaci on m asfinanciadas. Como resultado de este apoyo se ha producido un considerable avance en t ecnicasde observaci on, din amica en las regiones polares y, sobre todo, interacciones qu imicas entre lasespecies que influyen en el balance qu imico-radiativo del ozono. En el presente art iculo se haceuna revisi on general de la distribuci on del ozono en la estratosfera, mecanismos que intervienenen su equilibrio, gases que contribuyen a su destrucci on, situaci on actual y previsiones futurasdel estado de salud de la capa.
Caracterização e epidemiologia do trauma ocular no Conjunto Hospitalar de Sorocaba/SP (2005)

Introducao: O trauma ocular e a causa mais comum de cegueira unilateral em criancas e jovens. Este tipo de trauma e considerado como a terceira causa de hospitalizacao em Oftalmologia e como a segunda de comprometimento visual, depois da catarata. Objetivo: Avaliar a frequencia e os tipos de tramas oculares atendidos no Pronto Socorro do Centro Hospitalar de Sorocaba (CHS). Materiais e Metodos: Estudo prospectivo de 70 pacientes com historia de trauma ocular avaliados entre Fevereiro de 2003 e Fevereiro de 2004. Todos os pacientes foram submetidos a um questionario padronizado e exame oftalmologico. Resultados: Os homens foram os mais acometidos por trauma ocular, com idade predominante entre 20 e 29 anos. Houve maior numero de acometimento unilateral. O tipo de trauma mais frequente foi do tipo corpo estranho. Em todos os casos de trauma ocular por acidente automobilistico os pacientes nao utilizaram o cinto de seguranca. A maioria dos acometidos referiu nao estar sob o efeito do alcool no momento do trauma. A causa principal do trauma ocular foi por acidentes automobilisticos e a maioria dos pacientes estava a trabalho. O tratamento cirurgico foi necessario em 20% dos casos. O atendimento de 73% deles correu nas primeiras 24 horas. Dentre as complicacoes de carater mais grave, a laceracao de palpebra, a abrasao e a perfuracao corneanas estiveram entre as mais frequentes. Conclusao: O trauma ocular e um comprometimento frequente no atendimento emergencial, causa complicacoes e, na maioria dos casos, pode ser evitado atraves de prevencao adequada.
Isolation of the toxin in Daubentonia longifolia (1925)

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item.
Asymmetric, nonbroadened large optical cavity waveguide structures for high-power long-wavelength semiconductor lasers (2005)

We present a simple semianalytical model for evaluating the free-carrier loss in the waveguide layer of large-cavity semiconductor lasers, which proves that these losses may become an important factor at high bias currents. It is shown that nonbroadened asymmetric waveguide structures can significantly reduce these losses when compared to broadened symmetric waveguides, with little or no degradation in threshold, near- and far-field properties, and are thus a promising configuration for high-power lasers operating high above threshold.
Design of a Broadband HF Antenna for Multimode Naval Communications---Part II: Extension to VHF/UHF Ranges (2007)

This letter proposes a broadband antenna system with omnidirectional features, operating from 2 to 440 MHz. The basic antenna structure is the bifolded monopole, recently proposed as multimode high-frequency (HF) naval antenna, which is here augmented with a top-mounted discone mainly operating in the very-high-frequency (VHF) band. A mechanical and electrical integration strategy, which can be also extended to other antenna typologies, based on the lumped impedance loading to reduce the interantenna coupling, is described
Oxidation by metal salts. VII. Syntheses based on the selective oxidation of organic free radicals (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation by metal salts. VII. Syntheses based on the selective oxidation of organic free radicalsEl-Ahmadi I. Heiba and Ralph M. DessauCite this: J. Am. Chem. Soc. 1971, 93, 2, 524–527Publication Date (Print):January 1, 1971Publication History Published online1 May 2002Published inissue 1 January 1971https://doi.org/10.1021/ja00731a042RIGHTS & PERMISSIONSArticle Views955Altmetric-Citations113LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (452 KB) Get e-Alerts Get e-Alerts
Erythematous Eruption of the Palms and Soles Associated with Mitotane Therapy (1974)

An unusual eruption was observed in a man being treated with mitotane. His palms and soles developed an erythematous, edematous, partially petechial rash, which was present primarily in areas subjected to pressure. The patient experienced pruritus, burning, and tenderness in areas of the eruption.
Fulvestrant ('Faslodex')--a new treatment option for patients progressing on prior endocrine therapy. (2002)

Since its introduction more than 30 years ago, tamoxifen has been the most widely used endocrine therapy for the treatment of women with advanced breast cancer. More recently, a number of alternative endocrine treatments have been developed, including several selective estrogen receptor modulators (SERMs), aromatase inhibitors (AIs) and, most recently, fulvestrant ('Faslodex'). Fulvestrant is an estrogen receptor (ER) antagonist, which, unlike the SERMs, has no known agonist (estrogenic) effect and downregulates the ER protein. Tamoxifen is effective and well tolerated, although the non-steroidal AIs, anastrozole and letrozole, are more effective treatments for advanced disease than tamoxifen. Fulvestrant has recently gained US Food and Drug Administration approval for the treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following antiestrogen therapy. In two global phase III clinical trials fulvestrant was at least as effective and as equally well tolerated as anastrozole for the treatment of postmenopausal women with advanced and metastatic breast cancer. In a retrospective analysis of the combined data from these trials, mean duration of response was significantly greater for fulvestrant compared with anastrozole. These new hormonal treatments expand the choice of endocrine therapy for women with advanced breast cancer and offer new options for sequencing and combining treatments.
Degradability of fluorapatite-leucite ceramics in naturally acidic agents (2010)

This study was conducted to evaluate the titratable acidity and effect of naturally acidic agents on the surface microhardness, elemental composition, and surface morphology of fluorapatite-leucite ceramics. One hundred and ten ceramic disks (IPS d.SIGN), 12.0 mm in diameter and 2.0 mm in thickness, were fabricated. Before immersion, the baseline data of Vickers microhardness and elemental composition were recorded. Four groups were immersed in acidic agents (citrate buffer solution, green mango juice, and pineapple juice) and deionized water (control) at 37ºC for 168 hours, whereas one group was immersed in 4% acetic acid at 80ºC for 168 hours. After immersion, specimens were evaluated and data were analyzed using one-way repeated ANOVA and Tukey's test (α=0.05). Microhardness values significantly decreased after immersion (p<0.05). In terms of elemental composition, the weight percentages of silicon, potassium, aluminum, and sodium also decreased after immersion (p<0.05). Results of this study showed that fluorapatite-leucite ceramics were affected by long-term immersion in acidic agents.
Dynamic light scattering study of internal motions of polymer coils in dilute solution (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamic light scattering study of internal motions of polymer coils in dilute solutionBenjamin Chu, Zhulun Wang, and Jiqun YuCite this: Macromolecules 1991, 24, 26, 6832–6838Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/ma00026a005https://doi.org/10.1021/ma00026a005research-articleACS PublicationsRequest reuse permissionsArticle Views619Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Neurobiology and Pharmacotherapy of Alzheimer's Disease (1999)

Alzheimer's disease (AD), the most common cause of dementia, has become a major public health concern as our population ages. In recent years, AD has attracted the attention of a wide range of biological disciplines, and substantial progress has been made in understanding the mechanisms of neurodegeneration in AD. Four different genes have now been associated with AD and are providing insights into the pathogenesis of the disease. The roles of beta-amyloid, tau, hormonal changes, inflammation, and oxidative stress in the neurodegeneration of AD are also being delineated. Based on these discoveries, rational therapeutic strategies are developing rapidly. The authors review these and other recent advances in the neurobiology and pharmacotherapy of AD.
Advanced Thermoplastic Composite Development. (1979)

The objective of this program was to evaluate recently developed thermoplastic resins as matrix materials for graphite reinforced composites. Thermoplastic polymers (PKXA Polysulfone, Radel 5010 polyphenylsulfone, P-300, and KM-1 polyethersulfones, and CM-1 fluorocarbon based resin) having high temperature capability (+350 F) were evaluated as matrix materials for graphite reinforced composites. Resin characterization studies were performed. Prepreg processing and laminate molding parameters were optimized. Mechanical properties evaluations conducted consisted of flexure, tension, compression, shear, bearing, and impact strength. A study was conducted to determine resistance of the graphite fabric/thermoplastic composites to fluids likely to be encountered in aircraft flight and maintenance operations. Thin (0.01-in.) titanium sheet was bonded to the laminate faces and these 'clad' specimens immersed in fluids to determine if the clad specimens were more fluid resistant than unclad specimens. Postforming and thermal cycling studies were performed on the clad specimens. The feasibility of using two joining methods, spot fusion and use of a glue gun, for attaching graphite reinforced composite repairs patches to graphite reinforced composite structure was demonstrated. (Author)
Effective Ranking and Recommendation on Web Page Retrieval by Integrating Association Mining and PageRank (2008)

Nowadays, the well-known search engines, such as Google, Yahoo, MSN, etc, have provided the users with good search results based on special search strategies. However there still exist some problems unsolved for traditional search engines, including: (1) the gap between userpsilas intention and searched results is not easy to narrow down under the global search space, and (2) userpsilas interested pages hidden in the local website are not associated with the search results. To deal with such problems, in this paper, we propose a novel approach for personalized page ranking and recommendation by integrating association mining and PageRank so as to meet userpsilas search goals. Moreover, by mining the userspsila browsing behaviors, we can successfully bridge the gap between global search results and local preferences. The effectiveness of our proposed approach was verified through experimental evaluations.
<title>Optimization and performance of broadband microphone arrays</title> (1995)

This paper considers various wideband signal model optimization techniques and associated performance results for adaptive and steerable but fixed beam microphone array processing for hearing aid applications in freespace and reverberant conditions. We first review and compare various conventional broadband and narrowband array optimization techniques. These include the minimization of the output array power subject to desired signal distortion constraint; the maximization of the array gain subject to white noise gain and linear constraints; and maximum energy criterion subject to norm, linear, and quandratic distortion constraints. Then new results on maximum energy criterion broadband array optimization formulated for sub- band processing are presented. The uniformly spaced sub-band and the nonuniformly spaced sub-band using quandrature mirror filter approaches are treated. Finally, various simulation results under the maximum energy criterion for free-space and reverberant conditions are presented to demonstrate the usefulness of this class of microphone arrays.
Follow-Up Studies on Epstein &ndash; Barr virus IgA/VCA Antibody-Positive Persons in Zangwu County, China (1983)

Serological mass surveys were carried out in Zangwu County, China, using an immunoenzymatic test. 3,533 persons were found to have Epstein-Barr virus (EBV) IgA/VCA antibody among 148,029 persons age 30 years and older who were tested during 1978-1980. Among the IgA/VCA antibody-positive persons, 55 nasopharyngeal carcinoma (NPC) cases were detected. Follow-up studies were carried out yearly on the IgA/VCA antibody-positive persons for 1-3 years, and 32 additional NPC patients were diagnosed. IgA/VCA antibody was detected 8-30 months (average, 13 months) prior to the clinical diagnosis of stage I NPC. There was no marked difference in geometric mean titers of IgA/VCA antibody between the period before onset of NPC and after diagnosis at stage I, but antibody titers were higher during stages II-IV. The NPC detection rates for all persons tested serologically and for IgA/VCA antibody-positive persons, respectively, was 2- and 82-fold the annual incidence of NPC in the general population of the same age group. These data further indicate that serological testing is valuable for the diagnosis of NPC, especially in its early stages, and that EBV may play an important role in the development of NPC.
Editorial: Assessing the antimicrobial susceptibility of bacteria obtained from animals (2010)

The accurate performance of antimicrobial susceptibility testing of bacteria from animal sources and the correct presentation of the results is a complex matter. A review of the published literature revealed a number of recurring errors with regard to methodology, quality control, appropriate interpretive criteria, and calculation of MIC(50) and MIC(90) values. Although more subjective, there is also no consensus regarding the definition of multiresistance. This Editorial is intended to provide guidance to authors on how to avoid these frequently detected shortcomings.