gebhart/patrepeval huggingface dataset:
African Americans with genotype 1 treated with interferon for chronic hepatitis C have a lower end of treatment response than Caucasians (2001)

African Americans as a group have a higher incidence of chronic hepatitis C (CHC) than Caucasians but are often under-represented in clinical trials used to define response rates to interferon therapy. The aim of this study was to compare African Americans with Caucasians with respect to end-of-treatment response to interferon. This retrospective study had 61 African Americans and 49 Caucasians with CHC. All patients were treated for at least 12 weeks with interferon-alpha2b (Intron A) thrice weekly. End-of-treatment response was defined as three consecutive nondetectable HCV RNA measurements at least 1 month apart. Sustained response was defined as a negative serum HCV RNA 6 months after end of treatment. Of the 110 patients, 19 achieved an end-of-treatment response (17%) but only four achieved a sustained response (4/110=4%). Of the patients achieving a sustained response, one was genotype 1 (male Caucasian), three were genotype 2/3 with four patients having no follow-up information. The end-of-treatment response was 7% for patients with genotype 1 and 71% for genotype non-1 (P < 0.005 for genotype non-1). The end-of-treatment response was significantly higher in Caucasians (14/49=31%) compared with African Americans (5/61=8%; P < 0.05). A lower response rate in African Americans with genotype 1 in contrast to Caucasians was the primary reason for the difference in end-of-treatment response (1/45=2% vs. 5/33=15%, P < 0.05). Hence, interferon treatment resulted in a poor sustained response rate in the group of patients representative of the urban populations with the highest prevalence of hepatitis C. A genotype other than type 1 was the strongest predictor of end-of-treatment response in patients treated but over 86% of patients in this urban clinic were genotype 1. Caucasians were more likely to respond than African Americans, especially in patients with genotype 1.
Down-regulation of multiple low dose streptozotocin-induced diabetes by mycophenolate mofetil (2002)

The new immunosuppressive agent mycophenolate mofetil (MMF) has been shown recently to exert a protective effects in certain animal models of autoimmunity, including diabetes in diabetes-prone bio-breeding (BB) rats. In the present study, the immunomodulatory potential of MMF was investigated in autoimmune diabetes induced by multiple low doses of streptozotocin (MLD-STZ) in genetically susceptible DA rats 20 mg STZ/kg body weight (b.w.) for 5 days] and CBA/H mice (40 mg STZ/kg b.w. for 5 days). In both species, short time treatment of animals with MMF (25 mg/kg) during the early development of the disease, as well as continuous MMF treatment, prevented the appearance of hyperglycaemia and inflammatory infiltrates in the pancreatic tissue. Moreover, clinical manifestations of diabetes were suppressed by application of the drug after the onset of clinical symptoms. Treatment with guanosine (1 mg/kg) in parallel with MMF completely reversed MMF activity in vivo, indicating that inhibition of inosine monophosphate dehydrogenase (IMPDH) was responsible for the observed suppressive effects. MMF-mediated protection from diabetes correlated with reduced ex vivo spontaneous spleen mononuclear cell (MNC) proliferation and defective adhesive cell interactions. MMF-treated animals also had lower local production of IFN-gamma, as well as IL-12 and nitric oxide (NO) production by peripheral tissues (spleen and peritoneal cells), compared to that in control diabetic groups, while IL-10 level was elevated. Together, these data demonstrate that MMF interferes with autoimmune process in streptozotocin-induced diabetes at multiple levels, including lymphocyte proliferation and adhesion, as well as pro/anti-inflammatory cytokine balance.
Mutations associated with variant phenotypes in ataxia-telangiectasia. (1996)

We have identified 14 families with ataxia-telangiectasia (A-T) in which mutation of the ATM gene is associated with a less severe clinical and cellular phenotype (approximately 10%-15% of A-T families identified in the United Kingdom). In 10 of these families, all the homozygotes have a 137-bp insertion in their cDNA caused by a point mutation in a sequence resembling a splice-donor site. The second A-T allele has a different mutation in each patient. We show that the less severe phenotype in these patients is caused by some degree of normal splicing, which occurs as an alternative product from the insertion-containing allele. The level of the 137-bp PCR product containing the insertion was lowest in two patients who showed a later onset of cerebellar ataxia. A further four families who do not have this insertion have been identified. Mutations detected in two of four of these are missense mutations, normally rare in A-T patients. The demonstration of mutations giving rise to a slightly milder phenotype in A-T raises the interesting question of what range of phenotypes might occur in individuals in whom both mutations are milder. One possibility might be that individuals who are compound heterozygotes for ATM mutations are more common than we realize.
Attachment ofSalmonella typhimurium andListeria monocytogenes to glass as affected by surface film thickness, cell density, and bacterial motility (1991)

With equal cell densities, surface film thickness did not influence the numbers ofSalmonella typhimurium andListeria monocytogenes cells which attached to glass. MotileL. monocytogenes cells had a greater cell surface charge and generally attached in higher numbers than non-motile cells.
Temperature field estimation using electrical impedance profiling methods. I. Reconstruction algorithm and simulated results (1994)

Algorithmic methods for estimating complete temperature fields during hyperthermia treatments based on surface and internal electrical measurements are presented. The techniques utilized draw upon impedance imaging concepts, but rather than limit the measurements to positions on the body surface, internal impedance recording sites are allowed. Theoretical simulations show that this strategy improves the reconstructed image in the target region when either internal measurement locations are added to a given number of external recording sites or some external measurement locations are replaced by internal recording positions. The algorithms developed are tested on a set of problems with increasing levels of complexity. The culmination of these investigations is a complete simulation of a hyperthermia treatment and reconstruction of a thermal image for a body cross-section of an actual cancer patient. The results of this work suggest that the surface plus internal measurement approach holds some promise as a method for estimating temperature distributions during hyperthermia treatments. However, the simulations while promising are idealizations in that they are two-dimensional with modest levels of additive noise. In a companion paper, we explore the viability of this approach in several laboratory phantom experiments which include both static and heat-induced transient electrical property profiles.
[A clinical study of inhibition of secondary cataract with heparin]. (1994)

Extracapsular cataract extraction with posterior chamber lens implantation was performed on 47 eyes with senile cataract of which 25 eyes were in the control group and 22 eyes were irrigated with heparin solution (25U/ml) in the operation, the drug group. Postoperatively, 2 eyes with hyphema were found in the drug group, but the deposition of fibrin and cells on the anterior lenticular surface and the posterior capsular opacification were significantly less than those in the control group. 3 months after the operation, the mean visual acuity in the drug group was 0.70 +/- 0.26 markedly higher than that in the control group, 0.54 +/- 0.28 (P < 0.05).
On the effectiveness of local binary patterns in face anti-spoofing (2012)

Abstract—Spoofing attacks are one of the security traits that biometric recognition systems are proven to be vulnerable to. When spoofed, a biometric recognition system is bypassed by presenting a copy of the biometric evidence of a valid user. Among all biometric modalities, spoofing a face recognition system is particularly easy to perform: all that is needed is a simple photograph of the user. In this paper, we address the problem of detecting face spoofing attacks. In particular, we inspect the potential of texture features based on Local Binary Patterns (LBP) and their variations on three types of attacks: printed photographs, and photos and videos displayed on electronic screens of different sizes. For this purpose, we introduce REPLAY-ATTACK, a novel publicly available face spoofing database which contains all the mentioned types of attacks. We conclude that LBP, with ∼15 % Half Total Error Rate, show moderate discriminability when confronted with a wide set of attack types. I.
VIRUS‐CELL INTERACTIONS AS PROBES FOR VACUUM‐ULTRAVIOLET RADIATION DAMAGE AND REPAIR (1986)

Abstract Irradiation of biological materials in the vacuum‐ultraviolet (VUV*‐wavelengths below 200nm) is inhibited by the substantial absorption of water, air, and of the material itself. We have made a rough estimate of the penetration of radiation to the center of three kinds of cells and three viruses of different sizes at three wavelengths in the VUV (155 nm, 170 nm, and 200 nm) and two wavelengths in the far‐UV (220 nm and 250 nm). With the exception of bacteria, absorption limits the penetration of wavelengths below 200 nm to the center of the cell, to less than one percent of the radiation striking the cell surface. Thus, effects on the genetic material when cells larger than bacteria are irradiated with VUV should be insignificant. However, even the largest viruses were relatively transparent to all the wavelengths that we used. Therefore viruses can be considered to be model organisms for VUV studies; we list some of the maj or advantages of using them as probes to study cellular responses to VUV biological damage. The use of viral probes to study membrane phenomena also is noted since damage by VUV often is limited to cell surfaces. We suggest that the use of viruses may make possible biological experiments in the VUV that were not feasible with cells alone.
Balancing magnetic and electric responses of vector-sensing antenna (2002)

An antenna consisting of three collocated orthogonal doubly loaded thin wire loops is discussed. This antenna is capable of simultaneously sensing vectors of electric and magnetic fields. The response of each loop to the electric and magnetic field is found using classical theory of thin wire loops. It is shown that optimum balanced operation of the antenna can be obtained by selecting the loop size and the antenna load impedances.
<title>Dataspace: an automated visualization system for large databases</title> (1997)

DataSpace is a multi-platform software system for easily visualizing relational databases using a set of flexible 3D graphics tools. Typically, five attributes are selected for a given visualization session where two of the attributes are used to generate 2D plots and the other three attributes are used to position the 2D plots in a regular 3D lattice. Mouse-based 3D navigation with constraints allows the user to see the 'forest and the trees' without getting 'lost in space'. DataSpace uses the Standard Query Language to allow connection popular database systems. DataSpace also incorporates a variety of additional tools e.g., aggregation, data 'drill down', multidimensional scaling, variable transparency, query by example, and display of graphics from external applications. Labeling of node contents is automatic. 3D strokefonts are used to provide readable yet scalable text in a 3D environment. Since interactive 3D navigation is essential to DataSpace, we have incorporated several methods for adaptively reducing graphical detail without losing information when the host machine is overloaded. DataSpace has been sued to visualized databases containing over 1 million records with interactive performance. In particular, large databases containing stock price information and telecommunications customer profiles have been analyzed using DataSpace.
Resorcinol derivatives from <i>Ardisia maculosa</i> (2007)

Besides a series of known sterols and triterpenoids, a new resorcinol (1) and a known resorcinol (2) have been isolated from ethanol extract of Ardisia maculosa for the first time. The structures of these resorcinol derivatives were elucidated as 2-methyl-5-(Z-heptadec-8-enyl) resorcinol and 5-Z-heptadec-8-enyl) resorcinol by HRESI-MS, NMR ((1)H, (13)C, HSQC, HMBC) experiments. In our in vitro assay, compounds 1 and 2 showed no antimicrobial activities, however, compound 2 exhibited cytotoxity activity against human cancer cell line with GI(50) value of 2.14 x 10(- 4) mmol/ml.
A review of modern multiple hypothesis testing, with particular attention to the false discovery proportion (2007)

In the last decade a growing amount of statistical research has been devoted to multiple testing, motivated by a variety of applications in medicine, bioinformatics, genomics, brain imaging, etc. Research in this area is focused on developing powerful procedures even when the number of tests is very large. This paper attempts to review research in modern multiple hypothesis testing with particular attention to the false discovery proportion, loosely defined as the number of false rejections divided by the number of rejections. We review the main ideas, stepwise and augmentation procedures; and resampling based testing. We also discuss the problem of dependence among the test statistics. Simulations make a comparison between the procedures and with Bayesian methods. We illustrate the procedures in applications in DNA microarray data analysis. Finally, few possibilities for further research are highlighted.
Isolation and identification of the major urinary metabolite of 4-(4-fluorophenoxy)benzaldehyde semicarbazone after oral dosing to rats. (1999)

4-(4-Fluorophenoxy)benzaldehyde semicarbazone (1) is a novel anticonvulsant affording excellent protection in the rat oral maximal electroshock (MES) screen as well as having an apparent protection index of over 300. The metabolism of this compound was studied by examining the urine or rats dosed orally with 50 mg/kg of 1 which revealed that most of the drug was converted into one metabolite 2. The structure of 2 was shown by mass spectrometry to be 1-[4-(4-fluoro-phenoxy)benzoyl]semicarbazide which was confirmed by an independent synthesis. Compound 2 was bereft of activity in the rat oral MES screen when nine times the ED50 dose of 1 was administered. This datum provided strong evidence that the anticonvulsant activity of 1 and related compounds is due to the intact molecules and is not produced by breakdown products in vivo.
The Potential for Adaptive Safety through In-Vehicle Biomedical and Biometric Monitoring (2015)

A 2009 study by the National Highway Traffic Safety Administration identified certain medical conditions as contributing factors in crash causation (Hanna 2009). It was found that about 1.3% of all crashes included in the National Motor Vehicle Crash Causation Survey (NMVCCS) were precipitated by driver reported medical emergencies and 84% of the drivers in crashes precipitated by medical emergencies experienced seizures ( epileptic and others), blackouts (non-diabetic), and diabetic reaction prior to the crashes. Drivers who had crashes precipitated by medical emergencies were more likely to sustain severe injury (28% for incapacitating injury and death for crashes with medical emergency; 11% for crashes without medical emergency). Thus, the premise exists that there may be benefit to identify the driver (and other occupants) of the vehicle as well as monitor their current health status through passive or active methods. This monitoring could take into account chronic conditions (such as bone mineral density) through driver input or through initial vehicle startup measurements which could be used to provide optimal comfort or safety system performance. Additional information about the driver’s health or behavioral conditions could be interpreted from blood pressure, heart and respiration rate, blood glucose levels and other physiological parameters and could lead to vehicle intervention in driving and/or alert emergency medical service (EMS) or police of the impending health condition that may affect driving or cause a crash. This monitoring could be done in many ways such as the recent rapid growth in wearable technology with the ability to pair to apps. This paper will discuss issues related to driver behavioral and health monitoring and review potential technologies for monitoring and as well as methods for biometric identification. Recent publications on driver crash risk due to chronic and acute health conditions will be summarized. Finally, applications that may be associated with the monitoring will be discussed.
Low-swing on-chip signaling techniques: effectiveness and robustness (2000)

This paper reviews a number of low-swing on-chip interconnect schemes and presents a thorough analysis of their effectiveness and limitations, especially on energy efficiency and signal integrity. In addition, several new interface circuits presenting even more energy savings and better reliability are proposed. Some of these circuits not only reduce the interconnect swing, but also use very low supply voltages so as to obtain quadratic energy savings. The performance of each of the presented circuits is thoroughly examined using simulation on a benchmark interconnect circuit. Significant energy savings up to a factor of six have been observed.
Synthesis of Self-Photosensitizing Polyesters Carrying Pendant Norbornadiene (NBD) Moieties and Benzophenone Groups and Their Photochemical Reactions (1998)

Various epoxy monomers containing benzophenone (BP) groups were synthesized by reactions of potassium or lithium salts of BP derivatives with excess epichlorohydrin or epibromohydrin using tetrabutylammonium bromide (TBAB) as a phase transfer catalyst (PTC). The copolymerization of glycidyl 3-(piperidylcarbonyl)-2,5-norbornadiene-2-carboxylate (GPNC), which was prepared by the reaction of epichlorohydrin with potassium carboxylate of a norbornadiene (NBD) derivative using a PTC, and (glycidyloxy)benzophenone with phthalic anhydride (PAn) proceeded in 93% yield using TBAB as a catalyst in sulfolane at 100 °C for 24 h to give self-photosensitizing polyester P-1 containing a pendant NBD moiety and a pendant 4-oxybenzophenone group. Copolymerizations of various epoxy monomers containing certain NBD moieties and BP groups with PAn produced corresponding polyesters with pendant NBD moieties and BP groups in good yields. The photochemical valence isomerizations of the NBD moieties and the photosensitizing isomerizations of the NBD moieties due to the energy transfer from excited BP groups to the NBD moieties in the polymers were performed in the film state or in dichloromethane solution. From this result, it was found that rates of the photochemical isomerization of the NBD moieties in the polymers were strongly enhanced by the introduction of the pendant BP, N-alkyl-N,N‘,N‘-trimethyl-4,4‘-diaminobenzophenone (TBP), group. Furthermore, the photochemical isomerization of the NBD moieties in the polymers having a pendant TBP group proceeded effectively in a diluted dichloromethane solution compared with the mixtures of NBD polymers and low molecular weight photosensitizers such as 4,4‘-bis(N,N-diethylamino)benzophenone. Glass transition temperatures (Tg's) of the prepared polyesters having NBD moieties and stored thermal energy in the corresponding quadricyclane (QC) residues in the polymers were measured by DSC analysis. Then, it was found that Tg's of NBD polyesters were 30−85 °C, and photoirradiated polyesters having QC residues released their stored thermal energies (about 90 kJ/mol) at temperatures above the Tg's of the corresponding NBD polymers.
Signal-mediated nuclear transport in the amoeba (1999)

The evolutionary changes that occur in signal-mediated nuclear transport would be expected to reflect an increasing need to regulate nucleocytoplasmic exchanges as the complexity of organisms increases. This could involve changes in both the composition and structure of the pore complex, as well as the cytosolic factors that mediate transport. In this regard, we investigated the transport process in amoebae (Amoeba proteus and Chaos carolinensis), primitive cells that would be expected to have less stringent regulatory requirements than more complex organisms. Colloidal gold particles, coated with bovine serum albumin (BSA) conjugated with simple (large T) nuclear localization signals (NLSs), bipartite (nucleoplasmin) NLSs or mutant NLSs, were used to assay nuclear import. It was found that in amoebae (1) the diameter of the particles that are able to enter the nucleoplasm is significantly less than in vertebrate cells, (2) the simple NLS is more effective in mediating nuclear import than the bipartite NLS, and (3) the nucleoporins do not appear to be glycosylated. Evidence was also obtained suggesting that, in amoebae, the simple NLS can mediate nuclear export.
Tunable Novel Cyclopentadithiophene-Based Copolymers Containing Various Numbers of Bithiazole and Thienyl Units for Organic Photovoltaic Cell Applications (2009)

Six novel conjugated copolymers (P1−P6) containing coplanar cyclopentadithiophene (CPDT) units (incorporated with bithiazole/thienyl-based monomers) were synthesized and developed for the applications of polymer solar cells (PSCs). Copolymers P1−P6 covered broad absorption ranges from UV to near-infrared (400−800 nm) with narrow optical band gaps of 1.70−1.94 eV, which are compatible with the maximum solar photon reflux. Partially reversible p- and n-doping processes of P1−P6 in electrochemical experiments were observed. Compared with those previously reported CPDT-based narrow band gap polymers, the proper molecular design for HOMO/LUMO levels of P1−P6 induced relatively high photovoltaic open-circuit voltages in the PSC devices. Powder X-ray diffraction (XRD) analyses suggested that these copolymers formed highly self-assembled π−π stackings. Under 100 mW/cm2 of AM 1.5 white-light illumination, bulk heterojunction PSC devices containing an active layer of electron donor copolymers P1−P6 blended with electron acceptor [6,6]-phenyl C61 butyric acid methyl ester (PCBM) in the weight ratio of 1:1 were explored, and the external quantum efficiency (EQE) measurements showed a maximal quantum efficiency of 60%. The PSC device containing P4 in the weight ratio of 1:2 with PCBM gave the best preliminary result with an overall power conversion efficiency (PCE) of 3.04%, an open-circuit voltage of 0.70 V, a short-circuit current of 8.00 mA/cm2, and a fill factor of 53.7%.
Changes in the levels of glutathione after cellular and cutaneous damage induced by squalene monohydroperoxide (2001)

Squalene monohydroperoxide (Sq-OOH), the initial product of ultraviolet-peroxidated squalene, was used to investigate the effect of peroxidative challenge upon the glutathione contents in rabbit ear skin and primary-cultured fibroblasts derived from rabbit ear skin. The cellular reduced glutathione (GSH) contents decreased during 30-minute incubations in vitro with Sq-OOH, and oxidized glutathione (GSSG) was formed concomitantly, indicating that Sq-OOH had a potential for GSH-depleting activity in vitro. When Sq-OOH was applied topically to the skin in vivo, only GSSG contents increased significantly within 30 minutes. Moreover, pretreatment with the GSH depletors, DL-buthionine sulfoximine (BSO) and diethyl maleate (DEM), could potentiate the cytotoxicity and comedogenicity induced by Sq-OOH. These findings suggest that the endogenous antioxidant, glutathione, is quite sensitive to Sq-OOH and may be an important material for protecting cells and/or tissues against the oxidative stress induced by Sq-OOH treatment.