gebhart/patrepeval huggingface dataset:
The basement membrane glycoprotein entactin promotes cell attachment and binds calcium ions. (1990)

Mouse entactin derived from the extracellular matrix of M1536-B3 cells and from insect cells infected with a recombinant virus containing entactin sequences were shown to promote the attachment of mouse mammary tumor, human melanoma, and other cells. The cell attachment was inhibited by antibodies against mouse entactin but not by anti-fibronectin or anti-laminin antibodies. On a weight basis entactin was as effective as laminin in promoting the attachment of mouse mammary tumor cells. The attachment of cells to entactin was in part mediated by the integrin recognition RGD peptide sequence. This was demonstrated by the cell attachment properties of peptides derived from entactin which contained this sequence. Furthermore, the peptide RGDS could inhibit the attachment of mouse mammary tumor cells to entactin to approximately 60% of control. It is suggested that additional cell recognition sequences may be present in entactin. The direct binding of calcium ions to entactin was observed. It is probable that the binding sites reside in peptide sequences located toward the NH2 terminus region of entactin. This conclusion was supported by the demonstration that synthetic peptides, containing potential calcium binding sequences derived from entactin, bound calcium. In addition, a recombinant peptide containing the amino-terminal 330 amino acids of entactin also bound calcium ions. The significance of these properties of entactin is discussed.
Research on the application of single camera stereo vision sensor in three-dimensional point measurement (2015)

A single camera stereo vision sensor model based on planar mirror imaging is proposed for measuring a three-dimensional point. The model consists of a CCD camera and a planar mirror. Using planar mirror reflections of a scene, a picture with parallax is obtained by shooting the target object and its virtual image. This is equivalent to shooting the target object from different angles with the camera and the virtual camera in the planar mirror, so it has the function of binocular stereo vision. In addition, the measurement theory of the three-dimensional point is discussed. The mathematical model of a single camera stereo vision sensor is established, the intrinsic and extrinsic parameters are calibrated, and the corresponding experiment has been done. The experimental results show that the measuring method is convenient and effective; it also has the advantages of simple structure, convenient adjustment, and is especially suitable for short-distance measurement with high precision.
ANTIMALARIAL ACTIVITY OF HYDROXY‐SUBSTITUTED NAPHTHALENE COMPOUNDS (1957)

A new series of mono- and di-hydroxy substituted naphthalene compounds was synthesized and found to possess antimalarial activity against P. gallinaceum infection of young chicks. A representative compound with a high degree of activity was chosen for extensive testing against other malarial species and for pharmacological investigation. The formula of this compound, number 377C54, was 1:6-dihydroxy-2:5-bis(cyclohexylaminomethyl)naphthalene dihydrochloride. Effective doses against P. gallinaceum in chicks, P. berghei in mice and P. cathemerium in canaries were 2.3, 4.0, and about 6 mg./kg. respectively. Compound 377C54 acted rapidly against the parasitaemia of P. gallinaceum in chicks and P. knowlesi in a rhesus monkey. Parasiticidal activity remained in the blood of chicks for a long time after a single oral dose. The drug can be estimated by the production of colour on coupling with diazotized p-nitroaniline. Drug concentrations in blood from chicks and humans rose rapidly after oral administration. In tissues from chicks, particularly liver and lung, the drug persisted for a long period. An unsuccessful attempt was made to induce resistance to 377C54 in a strain of P. gallinaceum. Extensive pharmacological investigation showed that 377C54 possessed no special pharmacological properties.
Seawater as IOR Fluid in Fractured Chalk (2005)

Abstract The wetting nature of a carbonate reservoir determines the potential of improved oil recovery by water injection, especially if the formation is highly fractured, which often is the case for chalk formations. The initial wetting state is mostly governed by the properties of the crude oil, where the acid number, AN, appeared to be a crucial parameter. The reservoir temperature plays, however, a minor role as a wetting parameter. Improved oil recovery by water injection decreases as the water-wetness decreases due to decrease in spontaneous imbibition. The relative high specific surface area of chalk, about 2-3 m2/g, indicates that compositional properties of injected fluid could influence the wetting properties of the formation somewhat during the production phase. The exceptional good response of seawater injection into the Ekofisk formation is an indication of a special rockwater interaction, which improves the spontaneous displacement of oil. In the present paper, we will summarize the results from ongoing research to improve spontaneous imbibition of water into oil-containing chalk samples at various wetting states and temperatures. The chemical composition of the imbibing fluid is discussed in relation to the composition of initial brine and changes in the rock-fluid (water and oil) equilibrium conditions. Major observations are: (1) The presence of sulfate in seawater improved spontaneous imbibition at all wetting conditions tested. (2) Sulfate is a potential determinig ion towards chalk, which has impact on the wetting state in a positive way. (3) The adsorption of sulfate onto chalk increases as the temperature increases, which implies that the efficiency of sulfate as an active wettability modifier is improved as the temperature increases. (4) The relative increase in sulfate adsorption onto chalk increases at temperatures above 100°C. (5) Injection of produced water with a high Ca2+/SO4 2- ratio is recommended to be used only as pressure support and not as an oil displacing fluid.
MEOW with CATS: multimedia extensions over wireless with CTS-assisted transmission scheme (2005)

With the advent of the IEEE 802.11e QoS standard, an interesting issue that arises is the provision of QoS support for legacy 802.11 terminals. In this paper, we present an access point-based overlay to the 802.11 DCF protocol that provides priority access to standard endpoints without requiring any client modifications. This technique can be used to provide preferential channel access to legacy endpoints in 802.11 networks, thus allowing the use of legacy 802.11 equipment even with such legal requirements. The use of clear-to-send (CTS) frames underlies this technique and hence we call it CATS, the CTS-assisted transmission scheme. Our technique works by positioning a quiet window straddling the expected time when a protected endpoint becomes ready to transmit. We present two variants of our method depending on whether or not the access point (AP) is able to directly observe the signaling. Using time-stamped traces of VoIP frames, we evaluate the performance of CATS. We also provide a simplified efficiency analysis of CATS.
A FRACTURE BOARD TO FACILITATE THE MANAGEMENT OF SUPRACONDYLAR HUMERAL FRACTURES IN CHILDREN (1975)

A simple fracture board and its construction is described to facilitate the radiological and nursing management of children with supracondylar fractures of the humerus which are managed with lateral skeletal traction.
Transient activation of a distinct serine protein kinase is responsible for 27-kDa heat shock protein phosphorylation in mitogen-stimulated and heat-shocked cells. (1993)

We have investigated the phosphorylation of HSP27, a 27-kDa heat shock protein which is involved in cellular thermoresistance and is also an early target of phosphorylation during heat shock and cell stimulation by a variety of growth and differentiation factors. HSP27 is transiently phosphorylated after shifting Chinese hamster cells from their normal temperature of 37 to 44 degrees C. The phosphorylation correlated in time with the transient activation of specific HSP27 protein kinase activities. HSP27 kinase was also induced to maximal levels within 5-15 min following stimulation of quiescent cells with heat shock, serum, thrombin, or basic fibroblast growth factor. Extracts from quiescent cells stimulated by heat shock or serum were analyzed after sequential chromatography on cation exchange and hydroxylapatite columns. In both cases, a single and identical peak of HSP27 kinase activity was obtained, suggesting that the same protein kinase was induced. The HSP27 kinase efficiently phosphorylated recombinant Chinese hamster HSP27 or the synthetic peptide RALNRQLSSGV containing the major in vivo phosphorylation site of rodent HSP27. The kinase was inactive toward the ribosomal S6 protein, the peptide RALSSLRA from S6 protein, or the mutant HSP27 proteins with in vivo phosphorylation sites altered to glycine. The partially purified HSP27 kinase had no kinase C, kinase A, or S6 kinase activities; conversely, HSP27 was not a good substrate for these kinases. HSP27 kinase was rapidly inactivated in the presence of acid phosphatase, suggesting that its activity was regulated by phosphorylation. It is suggested that this heat shock- and serum-induced HSP27 kinase is a novel serine kinase which is linked to a major signal transduction cascade.
A Virtual Machine for Merit-Based Runtime Reconfiguration (2005)

This work advocates a merit-based reconfiguration policy. In the merit-based approach, each kernel that has a hardware implementation also has a software implementation. A runtime system performs continuous profiling of the application to decide which hardware reconfigurations are most profitable at any given time. Such a system can minimize thrashing, keeping the set of hardware-resident functionality constant over short intervals while still adapting to phased behavior in the application. Consequently, the system is better able to tolerate reconfiguration latencies. The main contribution of this work is the exhibition of a simple "merit" heuristic that can be used to direct reconfiguration. In this synopsis we present a brief overview of our ongoing work. First, a simple online algorithm for calculating a figure-of-merit for RTR systems is formalized. Next we describe its implementation and demonstrate a working prototype.
Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation (1998)

The OxyR transcription factor is sensitive to oxidation and activates the expression of antioxidant genes in response to hydrogen peroxide in Escherichia coli. Genetic and biochemical studies revealed that OxyR is activated through the formation of a disulfide bond and is deactivated by enzymatic reduction with glutaredoxin 1 (Grx1). The gene encoding Grx1 is regulated by OxyR, thus providing a mechanism for autoregulation. The redox potential of OxyR was determined to be -185 millivolts, ensuring that OxyR is reduced in the absence of stress. These results represent an example of redox signaling through disulfide bond formation and reduction.
The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver (1971)

Abstract A method is described for the enzymatic synthesis of 5'-adenylyl imidodiphosphate labeled with 32P at the α position (AMP-PNP-α-32P), an analogue of ATP containing nitrogen substituted for oxygen between the terminal phosphates. The nucleotide is only slowly hydrolyzed during incubation with rat liver plasma membranes and is a substrate for adenyl cyclase in these membranes. In the presence of 0.2 mm AMP-PNP, glucagon and fluoride ion stimulate adenyl cyclase activity; linear rates are maintained for at least 10 min of incubation at 30°. GTP enhanced the initial rate of basal and glucagon-stimulated adenyl cyclase activity. Reduction in concentration of Mg++ in the assay medium or incubation of liver membranes for 5 min at 30° prior to addition of glucagon results in loss of response of adenyl cyclase to glucagon and in reduction in the effects of GTP on basal activity. Under these conditions GTP, GDP, or GMP-PCP are required for glucagon stimulation of the enzyme even though the specific binding sites for glucagon are saturated with hormone; as little as 10 nm GTP or GDP is required. UTP and CTP exert smaller effects than the guanyl nucleotides and act only at concentrations higher than 0.1 mm. The guanyl nucleotides inhibited the response of adenyl cyclase to fluoride ion (10 mm) over the same concentration range over which they stimulate the response of the enzyme to glucagon. This action of the nucleotides is observed in plasma membranes treated with phospholipase A under conditions that result in loss of glucagon binding and of hormonal response. It is concluded that guanyl nucleotides play a specific and obligatory role in the activation of adenyl cyclase by glucagon. The nucleotides bind at sites, distinct from the glucagon binding sites, that appear to regulate both the response of adenyl cyclase to glucagon, and, possibly by a related mechanism, the actions of fluoride ion on this system.
Micro‐Engineered 3D Scaffolds for Cell Culture Studies (2012)

Abstract Cells in physiological 3D environments differ considerably in morphology and differentiation from those in 2D tissue culture. Naturally derived polymer systems are frequently used to study cells in 3D. These 3D matrices are complex with respect to their chemical composition, mechanical properties, and geometry. Therefore, there is a demand for well‐defined 3D scaffolds to systematically investigate cell behavior in 3D. Here, fabrication techniques, materials, architectures, biochemical functionalizations, and mechanical properties of 3D scaffolds are discussed. In particular, work focusing on single cells and small cell assemblies grown in tailored synthetic 3D scaffolds fabricated by computer‐based techniques are reviewed and the influence of these environments on cell behavior is evaluated. magnified image
Development of an Automatic Four-Color Spraying Device Carried by a Robot Arm (2007)

Development of an Automatic Four-Color Spraying Device Carried by a Robot Arm M. De Grassi, B. Naticchia, A. Giretti, A. Carbonari Pages 235-240 (2007 Proceedings of the 24th ISARC, Kochi, India, ISBN 978-81-904235-1-9, ISSN 2413-5844) Abstract: Automation of building processes is the right mean to improve the average productivity of the construction industry, moreover in case of big and very complex projects. In addition the manufacturing of uniform high quality products can be pursued. This paper is concerned on an automatic system for interior wall painting, which is devoted not only to set an automatic spraying device on one six degree of freedom robot called Pollock #1, but also to reproduce high quality artworks, using the same principles of four-color cartridges for printing machines. That end-tool was shown to be able to reproduce every color required by designers and, as a consequence, also drawings containing different chromatic scales, through controlling the movement of the arm with respect to the changeable colour mix sprayed by the end tool. Finally, an accurate and efficient automated methodology to reproduce colored drawings from their graphic digital format to their final application on building walls is presented. Keywords: Multicolor Painting Robot, Construction Robot, Miniature Laboratory, Scaled-Down Laboratory DOI: https://doi.org/10.22260/ISARC2007/0042 Download fulltext Download BibTex Download Endnote (RIS) TeX Import to Mendeley
Optimal Design of an N-Stage Nonlinear Transmission Line Based on Genetic Algorithm and LTspice (2013)

In this paper, we discuss a theoretical optimal design of a nonlinear transmission line using a genetic algorithm (GA) to achieve peak pulse power. The technique is based on an integrated optimization approach that uses a GA coded in Matlab and the circuit simulation program LTspice. A bidirectional interface is created that allowed information to be rapidly transferred between the circuit simulator and GA with real-time monitoring of the entire design process, including peak power and elemental values. The designed process shows a peak voltage enhancement of 318% while eliminating the tedious trial and error process usually required. It is important to note that this result is achieved using only six L-C segments and a much greater voltage increase is likely as the number of segments is increased.
Posttranslational modifications of the Ia-associated invariant protein p41 after gene transfer (1988)

Biochemical analysis of a rat fibroblast cell clone, transfected with the murine Ia associated invariant chain gene, demonstrates the expression of a family of proteins. This indicates that all members of the invariant protein family are derived from the same gene. The proteins p41, Ii, p27, p25, and p10, synthesized in the transfectant cell line, are identical with the invariant proteins previously shown to associate noncovalently with Ia antigens. These proteins are identified by immunoprecipitation and western blotting with a monoclonal antibody against the N-terminus and with an antiserum against the C-terminal part of the invariant chain. One protein, p41, has recently been shown to contain a thyroglobulin repeat (TgR) element. It was suggested that p41 might use the TgR element as a signal sequence which guides its intracellular transport to endosomes or lysosomes. Here, I demonstrate that p41 binds four N-linked carbohydrates and is heavily sialylated. During transport through trans Golgi compartments p41 binds palmitic acid, presumably at the same cytoplasmic cysteine as previously shown for Ii. A consensus sequence surrounding the palmitylated cysteine of the invariant chains (Ii, p41) and the human transferrin receptor was found. The transferrin receptor is known to follow an endocytic pathway, for which its cytoplasmic domain is essential. It is conceivable that the palmitylated domain of the invariant chains is a guiding structure for the membrane fusion process with transport vesicles. A role of the invariant proteins for antigen processing/presentation is discussed.
Accelerating development of metal organic framework membranes using atomically detailed simulations (2009)

A new group of nanoporous materials, metal organic frameworks (MOFs), have emerged as a fascinating alternative to more traditional nanoporous materials for membrane based gas separations. Although hundreds of different MOF structures have been synthesized in powder forms, very little is currently known about the potential performance of MOFs as membranes since fabrication and testing of membranes from new materials require a large amount of time and resources. The purpose of this thesis is to predict the macroscopic flux of multi-component gas mixtures through MOF-based membranes with information obtained from detailed atomistic simulations. First, atomically detailed simulations of gas adsorption and diffusion in MOFs combined with a continuum description of a membrane are introduced to predict the performance of MOF membranes. These results are compared with the only available experimental data for a MOF membrane. An efficient approximate method based on limited information from molecular simulations to accelerate the modeling of MOF membranes is then introduced. The accuracy and computational efficiency of different modeling approaches are discussed. A robust screening strategy is proposed to screen numerous MOF materials to identify the ones with the high membrane selectivity and to direct experimental efforts to the most promising of many possible MOF materials. This study provides the first predictions of any kind about the potential of MOFs as membranes and demonstrates that using molecular modeling for this purpose can be a useful means of identifying the phenomena that control the performance of MOFs as membranes.
OS TRÊS TEMPOS DA POESIA (2003)

RESUMO Este artigo discute a poesia a partir de uma perspectiva midiológica, em outras palavras, observa o curso histórico da poesia no ocidente, especialmente em língua portuguesa, levando em conta principalmente seus suportes de inscrição simbólica, com o intuito de rastrear as implicações políticas e culturais do papel do poeta nas diferentes rupturas históricas.
A New Randomized Order Preserving Encryption Scheme (2014)

Order Preserving Encryption (OPE) schemes have been examined to a great extent in the cryptography literature because of their prospective application to database design. OPE is an appealing method for database encryption as it permits to execute sort and range queries in an efficient manner without decrypting the data. Databases such as CryptDB are beginning to employ encryption to guard sensitive data. No existing OPE schemes that were proposed in the literature achieved IND-OCPA security except mutable Order-Preserving Encoding (mOPE) scheme, the first OPE scheme that satisfies IND-OCPA with respect to OPE encodings. However, mOPE scheme uses DET (deterministic encryption) to encrypt the plaintext values which leads to leakage of distribution of plaintext domain. This paper proposes a scheme called as Randomized Order Preserving Encryption (ROPE), a novel OPE scheme that leaks nothing beyond the order. ROPE follows the mOPE scheme by contributing randomness to it, so as to accomplish IND-OCPA security. The ROPE scheme implements insert, delete and query functions on an encrypted MySQL database. ROPE scheme permits various SQL queries to be employed instantly on encrypted data.The performance of ROPE scheme is compared with the existing DOPE scheme and observed that there is a query retrieval time overhead. Still, ROPE scheme renders more confidentiality and attains the IND-OCPA security for OPE when compared to the existing OPE schemes.
Comparison of the Performances of Two In-House Rapid Methods for Antitubercular Drug Susceptibility Testing (2008)

Resistance to rifampin (rifampicin), isoniazid, and streptomycin of 69 Mycobacterium tuberculosis isolates was analyzed by an in-house method based on mycobacteriophage D29 and a colorimetric micromethod. Both methods showed sensitivity and specificity values ranging from 93% to 100%. These simple methods offer an option for drug resistance assessment of M. tuberculosis.
Extremely small polarization beam splitter based on a multimode interference coupler with a silicon hybrid plasmonic waveguide (2014)

A novel polarization beam splitter (PBS) with an extremely small footprint is proposed based on a multimode interference (MMI) coupler with a silicon hybrid plasmonic waveguide. The MMI section, covered with a metal strip partially, is designed to achieve mirror imaging for TE polarization. On the other hand, for TM polarization, there is almost no MMI effect since the higher-order TM modes are hardly excited due to the hybrid plasmonic effect. With this design, the whole PBS including the 1.1 μm long MMI section as well as the output section has a footprint as small as ∼1.8 μm×2.5 μm. Besides, the fabrication process is simple since the waveguide dimension is relatively large (e.g., the input/output waveguides widths w ≥300 nm and the MMI width w(MMI)=800 nm). Numerical simulations show that the designed PBS has a broad band of ∼80 nm for an ER >10 dB as well as a large fabrication tolerance to allow a silicon core width variation of -30 nm<Δw<50 nm and a metal strip width variation of -200 nm<Δw(m)<0.
677. The infrared spectra and structures of some silver–ethylenediamine complexes (1962)

G. Newman and D. B. Powell, J. Chem. Soc., 1962, 3447 DOI: 10.1039/JR9620003447
Capsaicin-Sensitive Nerve Fibres Induce Epithelial Cell Proliferation, Inflammatory Cell Immigration and Transforming Growth Factor-alpha Expression in the Rat Colonic Mucosa In Vivo (2002)

Capsaicin-sensitive nerve fibres modulate epithelial cell proliferation and TGFalpha expression in colonic mucosa as well as a migration of inflammatory cells into the colonic mucosa. These effects are mediated by the neurotransmitters CGRP and SP.