gebhart/patrepeval huggingface dataset:
Association between Pesticide Exposure and Childhood Leukaemia: A Systematic Literature Review of Epidemiological Studies (2020)

Introduction: Cancer is the leading cause of death for children and adolescents globally with 300,000 children aged 0-19 are diagnosed with cancer every year, mainly leukaemia, lymphomas and brain cancers. Like other causes of cancer, the difficulty arises because of multi-factorial aetiologies involving the interaction between genetic factors as well as environmental exposures. Aims: This study aimed to analyse published studies on the relationship between childhood leukaemia and exposures to pesticides. Methods: The search on the literature database Ovid-MEDLINE search strategy was conducted for the period from 1995 to 2014. The quality of non-randomised studies was assessed by using Newcastle Ottawa Scale (NOS). Results: Six studies investigated the relationship related to parental residential exposure and one study, showed an association between childhood leukaemia and maternal exposure. Two studies investigated the relationship to maternal residential exposure. Two studies reported an association between childhood leukaemia and parental occupational exposure. One study showed a positive association out of two studies that evaluated the association related to parental occupational and residential exposure. This review provides evidence of weak to modest association between childhood leukaemia and pesticides exposure in most of the studies. Conclusion: Most studies showed an association; however, the causation remains unexplained because of limitations such as potential bias, faulty study design and sample frame, lack of statistical power and also ascertainment of exposure.
Eotaxin Activates T Cells to Chemotaxis and Adhesion Only if Induced to Express CCR3 by IL-2 Together with IL-4 (1999)

The transmigration and adherence of T lymphocytes through microvascular endothelium are essential events for their recruitment into inflammatory sites. In the present study, we investigated the expression of CC chemokine receptor CCR3 on T lymphocytes and the capacities of the CC chemokine eotaxin to induce chemotaxis and adhesion in T lymphocytes. We have observed a novel phenomenon that IL-2 and IL-4 induce the expression of CCR3 on T lymphocytes. We also report that CC chemokine eotaxin is a potent chemoattractant for IL-2- and IL-4-stimulated T lymphocytes, but not for freshly isolated T lymphocytes. Eotaxin attracts T lymphocytes via CCR3, documented by the fact that anti-CCR3 mAb blocks eotaxin-mediated T lymphocyte chemotaxis. In combination with IL-2 and IL-4, eotaxin enhances the expression of adhesion molecules such as ICAM-1 and several integrins (CD29, CD49a, and CD49b) on T lymphocytes and thus promotes adhesion and aggregation of T lymphocytes. The eotaxin-induced T lymphocyte adhesion could be selectively blocked by a specific cAMP-dependent protein kinase inhibitor, H-89, indicating that eotaxin activates T lymphocytes via a special cAMP-signaling pathway. Our new findings all point toward the fact that eotaxin, in association with the Th1-derived cytokine IL-2 and the Th2-derived cytokine IL-4, is an important T lymphocyte activator, stimulating the directional migration, adhesion, accumulation, and recruitment of T lymphocytes, and paralleled the accumulation of eosinophils and basophils during the process of certain types of inflammation such as allergy.
FPGA-based real-time anisotropic diffusion filtering of 3D ultrasound images (2005)

Three-dimensional ultrasonic imaging, especially the emerging real-time version of it, is particularly valuable in medical applications such as echocardiography and surgical navigation. A known problem with ultrasound images is their high level of speckle noise. Anisotropic diffusion filtering has been shown to be effective in enhancing the visual quality of 3D ultrasound images and as preprocessing prior to advanced image processing. However, due to its arithmetic complexity and the sheer size of 3D ultrasound images, it is not possible to perform online, real-time anisotropic diffusion filtering using standard software implementations. We present an FPGA-based architecture that allows performing anisotropic diffusion filtering of 3D images at acquisition rates, thus enabling the use of this filtering technique in real-time applications, such as visualization, registration and volume rendering.
Linkage disequilibria between Duffy blood groups, Fc gamma IIa and Fc gamma IIIb allotypes. (1997)

Fc gamma receptors (Fc gamma R) on white blood cells and the Duffy blood group antigens on red blood cells are coded for on the long arm of chromosome 1. They appear in different allotypic forms: the high responder/low responder (HR/LR) forms of Fc gamma RIIa, the alloantigens NA1 and NA2 of Fc gamma RIIIb and the Duffy blood group antigens Fya and Fyb. The aim of this study was to analyze possible linkage disequilibria between these allotypic immunomodulatory receptors, and thus provide evidence for the existence of a hypothetical gene complex. The Duffy phenotype was determined by the indirect antiglobulin test, NA1/NA2 phenotypes by the granulocyte agglutination test and the HR/LR polymorphism by an immunophagocytosis assay. Two haplotypes were found to be in linkage disequilibrium. For the haplotype NA2, Fyb we calculated a delta-value of -0.07 and for the haplotype NA1, HR we obtained a delta-value of -0.02.
Perchlorate reduction by a mixed culture in an up-flow anaerobic fixed bed reactor (1998)

Wolinella succinogenes HAP-1 is a Gram-negative microaerophile which reduces perchlorate to chloride by the proposed pathway ClO 4 to ClO 3 to ClO 2 to Cl + O 2 . A cost-effective perchlorate treatment process has been established using a consortium of facultative anaerobic organisms and W. succinogenes HAP-1. The mixed anaerobic bacterial culture containing W. succinogenes HAP-1 was examined for the ability to form a biofilm capable of perchlorate reduction. An up-flow anaerobic fixed bed reactor (UAFBR) was packed with diatomaceous earth pellets and operated at residence times of 1.17 and 0.46 h to insure a viable biofilm had attached to the diatomaceous earth pellets. Reduction rates of perchlorate to chloride in the UAFBR could be maintained at 1 g of perchlorate reduced h -1 L -1 . Studies with the same bacterial consortium in continuously stirred tank reactors (CSTR) generally reduced 0.5-0.7 g of perchlorate h -1 . Viable cell counts were performed periodically on the diatomaceous earth pellets and demonstrated that the W. succinogenes HAP-1 population was maintained at 28-47% of the total microbial population. Scanning electron micrographs demonstrated that the external and internal surfaces of the diatomaceous pellets were densely colonized with microbial cells of multiple cell types. This is the first report of an anaerobic mixed culture forming a biofilm capable of perchlorate reduction.
Dynamic measurement of pennation angle of gastrocnemius muscles during contractions based on ultrasound imaging (2012)

With the proposed methods, ultrasound measurement for muscle pennation angles can be more widely used for functional assessment of muscles.
Monoclonal antibody highly sensitive for the detection of ras p21 in immunoblotting analysis. (1987)

Four murine monoclonal antibodies (NCC-RAS-001, -004, -005, -017) reactive with ras p21 were produced by using recombinant c-Ha-ras p21 as an immunogen. Among these antibodies, NCC-RAS-004 was extremely sensitive when used in immunoblotting analysis, facilitating semiquantitative detection of c-Ha-, c-Ki- and N-ras p21 in cell and tissue lysates. In cells carrying a point-mutationally activated ras, p21 with abnormal mobility upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis was clearly detected.
HMGB1, TLR and RAGE: a functional tripod that leads to diabetic inflammation (2011)

Considering the involvement of the innate immune system, in association with the role of HMGB1 as an activator of TLR and RAGE, diabetes should be considered and treated as a metabolic and immunological disease, triggered by hyperglycemia. HMGB1 plays a central role in mediating injury and inflammation, and interactions involving HMGB1-TLR-RAGE constitute a tripod that trigger NF-κB activation. Blockade or downregulation of HMGB1, and/or control of the inflammatory tripod, represent a promising therapeutic approach for the treatment of diabetes.
Pharmacokinetics of etofylline after intravenous and oral administration to humans. (1981)

Etofylline is used in many countries as a bronchodilator. In a cross-over study in healthy volunteers serum concentrations and urinary excretion were studied after administration of etofylline (= beta-hydroxyethyltheophylline), intravenously and orally at a dose of 200 mg. Etofylline is a N-7 substituted theophylline derivative which dose not release theophylline in vitro or in vivo. It therefore has its own pharmacokinetic and pharmacodynamic properties. Its plasma decay after intravenous administration shows two-compartment kinetics with a rapid distribution. The alpha-phase lasted on the average 20 min and beta was 0.175 h(-1), corresponding with a beta-phase half-life of 4.1 h. The mean volume of distribution was 0.60 liter/kg, total body clearance 0.106 l.kg(-1).h(-1), and the renal clearance about 0.017 l.kg(-1).h(-1). About 20% of the drug is excreted unchanged in the urine. The curve determined after oral administration can be described by one-compartment kinetics. A comparison of the areas under the curve suggests that the drug was rapidly but incompletely absorbed from the gastrointestinal tract. Its bioavailability was about 80%. Mean peak levels of etofylline were about 3.9 mg/liter after oral administration. The normal dose advocated is 50-100 mg three times a day. With the Wagner-Nelson equation a mean steady state level for this dose can be calculated at about 0.7-1.4 g/ml. Since no information is available on the pharmacodynamic properties, no conclusion can be drawn about the therapeutic effectiveness of the drug.
Clock Tree Synthesis Based On Rc Delay Balancing (1992)

This paper presents a novel clock tree synthesis method based on top down binary tree constructicm, optimal buffer insertion, and bottom up wiring with precise RC delay balancing. The proposed method has achieved near-zero clock skews with minimal clock delays while achileving similar total wire lengths in comparison with previous heuristics.
Antioxidant Enzyme Activities and Gene Expression Patterns in Leaves of Kentucky Bluegrass in Response to Drought and Post-drought Recovery (2011)

The objectives of this study were to examine antioxidant enzyme responses to drought stress and rewatering at both enzymatic activity and transcript levels and to determine the major antioxidant processes associated with drought tolerance and post-drought recovery for a perennial grass species, kentucky bluegrass ( Poa pratensis ). Antioxidant enzyme responses to drought and rewatering in a drought-tolerant cultivar (Midnight) and a drought-sensitive cultivar (Brilliant) were compared in a growth chamber. Plants were exposed to 22 days of drought stress for ‘Midnight’ and 18 days for ‘Brilliant’ before rewatering to allow the leaf relative water content (RWC) of both cultivars to drop to the same level. ‘Midnight’ exhibited higher photochemical efficiency (F v /F m ) and lower electrolyte leakage compared with ‘Brilliant’ when at the same water deficit status (26% to 28% RWC). After 6 days of rewatering, all physiological parameters returned to the control level for ‘Midnight’, but only F v /F m fully recovered for ‘Brilliant’. The transcript level of cytosolic copper/zinc superoxide dismutase (cyt Cu/Zn SOD) and ascorbate peroxidase (APX) was significantly higher in ‘Midnight’ than in ‘Brilliant’ when exposed to the same level of water deficit (26% to 28% RWC), suggesting that SOD and APX could be involved in scavenging oxidative stress-induced reactive oxygen species in kentucky bluegrass through changes in the level of gene expression. Significantly higher activities of APX, monodehydroascorbate reductase, glutathione reductase, and dehydroascorbate reductase as well as lower lipid peroxidation levels were observed in ‘Midnight’ versus ‘Brilliant’ when exposed to drought. However, the activities of SOD, catalase (CAT), and guaiacol peroxidase (POD) did not differ between the two cultivars. After 6 days of rewatering, ‘Midnight’ displayed significantly higher activity levels of CAT, POD, and APX compared with ‘Brilliant’. The enzyme activity results indicate that enzymes involved in the ascorbate–glutathine cycle may play important roles in antioxidant protection to drought damage, whereas CAT, POD, and APX could be associated with better post-drought recovery in kentucky bluegrass.
Cloud mobile gaming (2012)

With the evolution of mobile devices and networks, and the growing trend of mobile Internet access, rich multi-player gaming using mobile devices, similar to PC-based Internet games, has tremendous potential and interest. However, the current client-server architecture for PC-based Internet games, where most of the storage and computational burden of the game lies with the client device, does not work with mobile devices, constraining mobile gaming to either downloadable, single player games, or very light non-interactive versions of the rich multi-player Internet games. In this article, we study a cloud server based mobile gaming approach, termed Cloud Mobile Gaming (CMG), where the burden of executing the gaming engine is put on cloud servers, and the mobile devices just communicate the users' gaming commands to the servers. We analyze the factors affecting the Quality of user Experience (QoE) using the CMG approach, including the game genres, video settings, the conditions of server and client, and the conditions of the wireless network. A Mobile Gaming User Experience (MGUE) model is developed and validated through controlled subjective testing. We also develop a prototype for in-service measuring MGUE, and then use it to characterize user experience achievable using the CMG approach in a mobile cellular network. The MGUE model developed and validated in this article will be helpful for researchers and service providers to develop and assess the performance of future cloud mobile gaming techniques and services.
Resazurin reduction test to evaluate semen quality. (1997)

The resazurin test (REZ TEST) was performed on semen samples obtained from 75 untreated subfertile and 10 pregnancy confirmed fertile males. The results were compared with other sperm parameters to assess the quality of semen. The highest correlation of REZ grade was with motile sperm (r = 0.90, P < 0.001), sperm viability (r = 0.80, P < 0.001) and sperm concentration (r = 0.71, P < 0.001). The REZ grade indicated significant difference in the rate of positive tests between samples from fertile males and patients exhibiting abnormal semen parameters. The RES TEST had a positive predictive value of 93.75% for a progressives motile sperm concentration of > 20 x 106/ml and a negative predictive power of 88.7% for the same variable at a criterion value of 10 x 106/ml. It is suggested that REZ TEST can be performed with a relatively small volume of semen, it is easy to perform and requires no technical equipments.
Implementation and demonstration of receiver-coordinated distributed transmit beamforming across an ad-hoc radio network (2012)

Distributed transmit beamforming using an ad-hoc network of 10 RF transmitters was demonstrated using radio nodes developed from off-the-shelf components and modules. A time-slotted protocol allowed carrier phases from each transmitter to be measured at a receiver and fed back to the transmitters where Kalman filters were used to predict the offset phases and frequencies. Offsets were digitally compensated for during beamforming intervals. Beamforming gain within 0.1dB of ideal was demonstrated across 1 km at 910MHz. This is the first report (to our knowledge) of a successful outdoor RF distributed transmit beamforming experiment using independent clocks at this scale.
Beyond Overeating (1995)

The folk belief that overeating causes obesity has influenced clinical thinking with remarkable tenacity, despite two fatal flaws in the theory. First, the proposition is logically vacant, inasmuch as the definition of overeating is circular; only if one is fat can one be said to have overeaten. Second, whenever the proposition has been reframed so as to have meaning and then tested in a well-designed experiment, eating behavior has appeared to be the dependent variable, rather than the independent variable.The best evidence, derived mostly from studies in animals but increasingly confirmed by difficult experiments in humans (such as that . . .
A bi-level object-oriented data model for GIS applications (2002)

A bi-level object-oriented data model together with a user query language called OFQL is designed which can support applications like GIS (geographic information systems). The data model is divided into two layers, the higher-level data model and the lower-level data model. The higher-level data model or the geographic object data model primarily consists of the geographic objects and a set of semantic spatial functions through which the topological relationships of the geographic objects are defined or derived. The lower-level data model or the geometric object data model has geometric objects which are the actual spatial representations of the geographic objects in the higher-level data model. It also has a set of geometric functions that retrieve, manipulate, and compute for geometric objects. The general architecture of a GIS system using this data modeling approach consists of two modules: the query processor and the function implementor. With the OFQL user-interface, the user is able to pose queries of a geographic nature without knowing the details of the spatial representation and computation of the geographic objects.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
新浪潮：网络革命2．0 (2005)

到农村去,像红桃K一样刷广告!在上海黄浦江边的一个星巴克咖啡店里,一群人七嘴八舌地给王建硕出主意.王建硕是客齐集网站中国区负责人,此时他正端着一杯咖啡,与众人兴奋地讨论如何让大多数中国人知道客齐集.参加聚会的都是与互联网业相关的网站负责人、风险投资商与媒体人士.在同样的地点,几乎每周都有类似的聚会,他是所有这些聚会里的核心角色之一.
Ability of the orally effective iron chelators dimethyl- and diethyl- hydroxypyrid-4-one and of deferoxamine to restore sarcolemmal thiolic enzyme activity in iron-loaded heart cells (1994)

In view of the profound functional and structural abnormalities shown in our previous studies in cultured, iron-loaded rat heart cells, we have examined the ability of the orally effective iron chelators dimethyl-3-hydroxypyrid-4-one (DMHP or L1) and diethyl-3-hydroxy-pyrid-4-one (DEHP or CP94) and of deferoxamine (DF) to reverse the damage caused by iron loading to heart cell organelles. At a concentration of 1.0 mmol/L, all three iron chelators were equally efficient in removing iron and restoring the activity of the thiolic sarcolemmal enzymes 5'-nucleotidase and Na,K,ATPase. However, at 0.1 mmol/L DMHP and DEHP were less effective than DF both in their iron-mobilizing effect and in promoting thiolic enzyme recovery. The superior efficiency of DF at low concentrations illustrates the advantage of the hexadentate chelating action of DF as compared with bidentate chelators such as DMHP and DEHP requiring a 3 to 1 molar ratio to iron for optimal effect. In contrast to its beneficial effect on sarcolemmal enzyme activity, iron chelation was unable to reverse the increase in beta-hexosaminidase activity caused by abnormal lysosomal fragility. Our study demonstrates for the first time that iron-induced peroxidative damage to the myocardial cell is associated with a marked loss of Na,K,ATPase activity, an enzyme with a major role in the maintenance of cellular resting potential. The timing of this damage and the restoration of Na,K,ATPase function by iron-chelating treatment suggest a cause-and-effect relationship between the observed injury to the sarcolemmal enzyme and the reversible electrophysiologic abnormalities observed in the same heart culture system in our previous studies.
Protein composition of the human heart: The construction of a myocardial two‐dimensional electrophoresis database (1994)

Molecular changes occurring in myocardial diseases are not well understood. Proteins, as regulatory molecules, should play an important role in the etiology of these diseases. The method of two-dimensional electrophoresis (2-DE) allows the analysis of some thousand proteins with one experiment. An important prerequisite for this kind of investigation is the possibility of identifying the proteins separated by 2-DE. We resolve 3239 proteins of the human myocardium and tried to identify 33 proteins by amino acid analysis and microsequencing. Twenty proteins were identified by search for the protein-chemical data obtained in the Martinsried Institute Protein Sequence Database. Comparisons of 2-DE patterns of different size, which were obtained in different laboratories, were performed with the result that proteins identified on a 2-DE map of one laboratory can be assigned to spots of 2-DE maps produced by another laboratory. Our results show the usefulness of a myocardial 2-DE database; they can be used in different laboratories and make it possible to generate a collection of important human myocardial proteins in a 2-DE database for comparative studies worldwide.
Safe side effects commitment for OS-level virtualization (2011)

A common application of virtual machines (VM) is to use and then throw away, basically treating a VM like a completely isolated and disposable entity. The disadvantage of this approach is that if there is no malicious activity, the user has to re-do all of the work in her actual workspace since there is no easy way to commit (i.e., merge) only the benign updates within the VM back to the host environment. In this work, we develop a VM commitment system called Secom to automatically eliminate malicious state changes when merging the contents of an OS-level VM to the host. Secom consists of three steps: grouping state changes into clusters, distinguishing between benign and malicious clusters, and committing benign clusters. Secom has three novel features. First, instead of relying on a huge volume of log data, it leverages OS-level information flow and malware behavior information to recognize malicious changes. As a result, the approach imposes a smaller performance overhead. Second, different from existing intrusion detection and recovery systems that detect compromised OS objects one by one, Secom classifies objects into clusters and then identifies malicious objects on a cluster by cluster basis. Third, to reduce the false positive rate when identifying malicious clusters, it simultaneously considers two malware behaviors that are of different types and the origin of the processes that exhibit these behaviors, rather than considers a single behavior alone as done by existing malware detection methods. We have successfully implemented Secom on the Feather-weight Virtual Machine (FVM) system, a Windows-based OS-level virtualization system. Experiments show that the prototype can effectively eliminate malicious state changes while committing a VM with small performance degradation. Moreover, compared with the commercial anti-malware tools, the Secom prototype has a smaller number of false negatives and thus can more thoroughly clean up malware side effects. In addition, the number of false positives of the Secom prototype is also lower than that achieved by the on-line behavior-based approach of the commercial tools.