gebhart/patrepeval huggingface dataset:
KAP1, a Novel Substrate for PIKK Family Members, Colocalizes with Numerous Damage Response Factors at DNA Lesions (2006)

The DNA damage response requires a coordinated nucleo-cytoplasmic cascade of events, which ultimately converge on damaged DNA packaged in chromatin. Few connections between the proteins that remodel chromatin and the proteins that mediate this damage response have been shown. We have investigated the DNA damage-induced phosphorylation of the KRAB-ZFP-associated protein 1 (KAP1), the dedicated corepressor for Krüppel-associated box (KRAB) zinc finger protein (ZFP) proteins. We show that KAP1 is rapidly phosphorylated following DNA damage by members of the phosphatidylinositol-3 kinase-like family of kinases. This phosphorylation occurs at a single amino acid residue that is conserved from mice to humans and is located adjacent to the bromodomain, suggesting that it may regulate chromatin recognition by that module. Phosphorylated KAP1 rapidly localizes to sites of DNA strand breaks in the nucleus in response to ionizing radiation. This discovery provides a novel link between chromatin-mediated transcriptional repression and the recognition/repair of DNA, which must be accomplished by the cellular DNA damage response.
Improving interface designs to help users choose better passwords (2006)

Conventional wisdom seems to have concluded that traditional passwords are inherently insecure. The argument is usually that users choose bad passwords and cannot be expected to remember strong passwords. We feel that these conclusions are premature and that this argument is flawed. At present most password selection mechanisms are not designed according to basic HCI principles and we believe that this is highly responsible for the above conclusions. Our current research is reexamining the problem of password selection and memorability through the exploration of password selection mechanisms with novel interface designs. The goal of this research is develop both principles and designs that help users to choose passwords that are both memorable and secure.
Fast algorithms for large scale conditional 3D prediction (2008)

The potential success of discriminative learning approaches to 3D reconstruction relies on the ability to efficiently train predictive algorithms using sufficiently many examples that are representative of the typical configurations encountered in the application domain. Recent research indicates that sparse conditional Bayesian mixture of experts (cMoE) models (e.g. BME (Sminchisescu et al., 2005)) are adequate modeling tools that not only provide contextual 3D predictions for problems like human pose reconstruction, but can also represent multiple interpretations that result from depth ambiguities or occlusion. However, training conditional predictors requires sophisticated double-loop algorithms that scale unfavorably with the input dimension and the training set size, thus limiting their usage to 10,000 examples of less, so far. In this paper we present large-scale algorithms, referred to as fBME, that combine forward feature selection and bound optimization in order to train probabilistic, BME models, with one order of magnitude more data (100,000 examples and up) and more than one order of magnitude faster. We present several large scale experiments, including monocular evaluation on the HumanEva dataset (Sigal and Black, 2006), demonstrating how the proposed methods overcome the scaling limitations of existing ones.
Gyrators Application in Power Processing Circuits (1987)

The gyrator is a lossless two-port network which transforms one-port networks into its dual with respect to its gyration conductance. For example, capacitance at the gyrator output is viewed as inductance at the input and a voltage source is transformed to a current source.
Cross-Scale Cost Aggregation for Stereo Matching (2014)

Human beings process stereoscopic correspondence across multiple scales. However, this bio-inspiration is ignored by state-of-the-art cost aggregation methods for dense stereo correspondence. In this paper, a generic cross-scale cost aggregation framework is proposed to allow multi-scale interaction in cost aggregation. We firstly reformulate cost aggregation from a unified optimization perspective and show that different cost aggregation methods essentially differ in the choices of similarity kernels. Then, an inter-scale regularizer is introduced into optimization and solving this new optimization problem leads to the proposed framework. Since the regularization term is independent of the similarity kernel, various cost aggregation methods can be integrated into the proposed general framework. We show that the cross-scale framework is important as it effectively and efficiently expands state-of-the-art cost aggregation methods and leads to significant improvements, when evaluated on Middlebury, KITTI and New Tsukuba datasets.
Diagnoses in a dizziness unit. (1986)

Data are given on 2,515 patients who attended the Dizziness Unit on 3,113 visits. The sex incidence was 58% female, 42% male, and the sex preference most marked in the psychogenic group from ages 20 to 50. Dizziness is mainly a condition of middle-age; with a steadily aging population we can expect a disproportionate increase in patients with dizziness. Psychogenic dizziness was the commonest of all diagnoses (21.1%), followed closely by "undiagnosed"; together, these two comprised 40% of all diagnoses. Obviously, they deserve more clinical attention than such relatively rare conditions as delayed endolymphatic hydrops (0.5%) or inner ear fistula (0.4%). For all diagnostic categories, on repeated visits the original diagnosis was changed in about one-third of cases. Diagnostic conversion was most frequent in "undiagnosed", at a level of 58%.
Efficient homology-directed gene editing by CRISPR/Cas9 in human stem and primary cells using tube electroporation (2018)

CRISPR/Cas9 efficiently generates gene knock-out via nonhomologous end joining (NHEJ), but the efficiency of precise homology-directed repair (HDR) is substantially lower, especially in the hard-to-transfect human stem cells and primary cells. Herein we report a tube electroporation method that can effectively transfect human stem cells and primary cells with minimal cytotoxicity. When applied to genome editing using CRISPR/Cas9 along with single stranded DNA oligonucleotide (ssODN) template in human induced pluripotent stem cells (iPSCs), up to 42.1% HDR rate was achieved, drastically higher than many reported before. We demonstrated that the high HDR efficiency can be utilized to increase the gene ablation rate in cells relevant to clinical applications, by knocking-out β2-microglobulin (B2M) in primary human mesenchymal stem cells (MSCs, 37.3% to 80.2%), and programmed death-1 (PD-1) in primary human T cells (42.6% to 58.6%). Given the generality and efficiency, we expect that the method will have immediate impacts in cell research as well as immuno- and transplantation therapies.
A New Automatic Color Camera (1972)

To achieve the minimum size consistent with full broadcast quality of picture, three full-size lead oxide vidicons are used and special techniques employed to improve the registration accuracy and tolerance of the three-tube camera to the inevitable minor variations in registration errors occurring during operation. By the employment of a novel optical system, the sensitivity has been raised well above that of existing cameras.
Development Authentication and Authorization Systems of Multi Information Systems Based REst API and Auth Token (2020)

The security of an application is the most important problem in an information system integration process. The authentication and authorization process is usually carried out using Single Sign On (SSO). Authentication and authorization methods are used to secure data in a system. The authentication and authorization processes are carried out on the client side (web browser) in the form of a session and on the server side (web server) in the form of cookies. Sessions and cookies are valuable assets in the authentication and authorization process because they contain the data required for the login process so that the session and cookies need to be secured. Session is a combination of username and password data that has been encrypted while cookies store login information data so that they are still in a state of gaining access according to the privileges given to the user. So important is the role of sessions and cookies in the authentication and authorization process, so we need a way to secure data on sessions and cookies. One way to secure data is to use the REst API and Auth Token.
ChemInform Abstract: CONDENSATION OF O‐SUBSTITUTED ARYL AZIDES WITH AROMATIC ALDEHYDES: A NOVEL SYNTHESIS OF 2‐ARYL‐3,1‐BENZOXAZ‐4‐ONES AND 4(3H)‐QUINAZOLINONES (1979)

Abstract Kondensation der Arylazide (I) mit den Aldehyden (II) führt zu den 3,1‐Benzoxaz‐4‐onen (IIIa) und den 4(3H)‐Chinazolinonen (IIIb)‐(IIId).
Percussion Drilling…Is It a Lost Technique? A Review. (1996)

Abstract This paper presents a review of the benefits and performance of downhole percussion hammers. The advancement of drilling technology and the extensive use of coiled tubing coupled with different downhole motors prompted another look at the percussion type of drills. Achieving very high extended reach wells also have necessitated a high axial driving mechanism. The potential benefits of the percussion type of drilling machine for future operations are given, supported by the performance of the tools. The use envelope and the benchmarks of the tools by different manufacturers down the years have been discussed. The hammers developed and operated have been supported by enough field runs to prove the sustainment of the tools. Different models of downhole hammers can be categorized as first generation tools which include the developments from early time to the development of Bassinger tools. The second generation tools from post-Bassinger to the recent developments are discussed broadly. The basic principle involved and the necessity to consider the correct stress waveform to simulate the performance of the downhole hammer energy transfer are reviewed.
Comparative analysis of similarity measures for sentence level semantic measurement of text (2013)

The accuracy of similarity measurement between sentences is critical to the performance of several applications such as text mining, question answering, and text summarization. This paper focuses on calculating semantic similarities between sentences and performing a comparative analysis among identified similarity measurement techniques. Comparison between three popular similarity measurements which are Jaccard, Cosine and Dice similarity measures has been conducted. The performance of each identified measurement was evaluated and recorded. In this paper, we use a large lexical database of English known as WordNet to calculate the word-to-word semantic similarity. The result of this research concludes that the Jaccard and Dice performs better in measuring the semantic similarity between sentences.
<i>Arabidopsis</i> WRKY38 and WRKY62 Transcription Factors Interact with Histone Deacetylase 19 in Basal Defense (2008)

Arabidopsis thaliana WRKY38 and WRKY62, encoding two structurally similar type III WRKY transcription factors, are induced in a Nonexpressor of PR Gene1 (NPR1)-dependent manner by salicylic acid (SA) or by virulent Pseudomonas syringae. Disease resistance and SA-regulated Pathogenesis-Related1 (PR1) gene expression are enhanced in the wrky38 and wrky62 single mutants and, to a greater extent, in the double mutants. Overexpression of WRKY38 or WRKY62 reduces disease resistance and PR1 expression. Thus, WRKY38 and WRKY62 function additively as negative regulators of plant basal defense. WRKY38 and WRKY62 interact with Histone Deacetylase 19 (HDA19). Expression of HDA19 is also induced by P. syringae, and the stability of its induced transcripts depends on SA and NPR1 in infected plants. Disruption of HDA19 leads to compromised resistance, whereas its overexpression results in enhanced resistance to P. syringae. Thus, HDA19 has a role opposite from those of WRKY38 and WRKY62 in basal resistance to the bacterial pathogen. Both WRKY38 and WRKY62 are transcriptional activators in plant cells, but their activation activities are abolished by overexpressed HDA19. Interaction of WRKY38 and WRKY62 with HDA19 may act to fine-tune plant basal defense responses.
Blade Tip Measurement Advanced Visualization Using a Three Dimensional Representation (2011)

A microwave tip clearance sensor capable of measuring the hottest stages of industrial and aero gas turbines has been developed. This new microwave sensor has been integrated into a commercial package for online real-time monitoring of machine data. However, data analysis of large numbers of tip clearance probes makes standard industry graphic techniques cluttered. A method has been developed to reduce this data and visualize it in order to provide intuitive representations of the data from which a user can quickly draw the right conclusions about machine behavior. The main motivation for the development of a 3D graphical user interface is the density of information that can be shown to the user at one time. Tip clearance measurement is very data-rich, as every individual blade for each sensor mounted around the engine case is available. The result is that it may be difficult to find slight changes within hundreds of clearance trends. Only specialists with long experience in tip clearance measurement can synthesize all the data quickly enough using standard 2D plots. The 3D graphical user interface brings all of this data together to calculate the aggregated blade pattern, rotor positioning, and estimated case shape. All of these measurements are available to the user in a single visualization. Colors indicating alarm or clearance scale quickly draw attention to the most important data such as the minimum clearance point around the engine case where a rub may be likely to occur. This method is based about a case shape fitting algorithm that combines data from multiple sensors to make a case shape estimate based on fitting of a non-uniform rational B-spline (NURB). The scaling is also distorted in order to accentuate the graphics in a way that provides an intuitive understanding of the machine state. The method of applying this data accentuation is important so as to not be misleading. This innovative navigation interface presented in this paper capitalizes on modern advances in computer graphics to aid engineers and operators in understanding, access, monitoring, and analysis of tip clearance and air-gap measurements.
Controlled Growth of Well-Aligned ZnO Nanorod Array Using a Novel Solution Method (2005)

A simple method of synthesizing nanomaterials and the ability to control the size and position of them are crucial for fabricating nanodevices. In this work, we developed a novel ammonia aqueous solution method for growing well-aligned ZnO nanorod arrays on a silicon substrate. For ZnO nanorod growth, a thin zinc metal seed layer was deposited on a silicon substrate by thermal evaporation. Uniform ZnO nanorods were grown on the zinc-coated silicon substrate in aqueous solution containing zinc nitrate and ammonia water. The growth temperature was as low as 60-90 degrees C and a 4-in. wafer size scale up was possible. The morphology of a zinc metal seed layer, pH, growth temperature, and concentration of zinc salt in aqueous solution were important parameters to determine growth characteristics such as average diameters and lengths of ZnO nanorods. We could demonstrate the discrete controlled growth of ZnO nanorods using sequential, tailored growth steps. By combining our novel solution method and general photolithography, we selectively grew ZnO nanorod arrays on a patterned silicon substrate. Our concepts on controlled ZnO nanorod growth using a simple solution method would be applicable for various nanodevice fabrications.
INDUCTION OF DONOR-SPECIFIC UNRESPONSIVENESS TO CARDIAC ALLOGRAFTS IN RATS BY PRETRANSPLANT ANTI-CD4 MONOCLONAL ANTIBODY THERAPY (1990)

In the present report a monoclonal antibody designated OX-38 directed against the rat CD4 molecule was tested for its ability to prolong the survival of heterotopic vascularized rat heart allografts transplanted across major histocompatibility barriers. Fluorescence-activated cell-sorter analysis showed that administration of OX-38 selectively depleted 80-95% of CD4+ cells from peripheral blood of treated rats. The immunosuppressive effects of OX-38 in vivo were verified by suppression of an antibody response against OX-38 itself as a heterologous protein immunogen. Recipient rats received OX-38 antibody as a single agent given in pretransplant regimens. Nine of 12 treated rats have maintained heterotopic abdominal heart allografts for greater than 175 days. Control rats that did not receive antibody therapy rejected their grafts within 14 days. Rats that maintained heart allografts for greater than 100 days accepted second donor strain hearts but rejected third-party heart grafts transplanted into the femoral space. Anti-CD4-induced allograft unresponsiveness persisted for at least 90 days following surgical removal of donor tissue and retransplantation of a second donor-matched heart. These results indicated that transient, pretransplant therapy with monoclonal antibodies directed against the CD4+ lymphocyte induced specific, long-lasting unresponsiveness to fully MHC-mismatched cardiac allografts in rats without additional immunosuppression.
Biomechanics and biocompatibility of the perfect conduit-can we build one? (2013)

No currently available conduit meets the criteria for an ideal coronary artery bypass graft. The perfect conduit would combine the availability and complication-free harvest of a synthetic vessel with the long-term patency performance of the internal mammary artery. However, current polymer conduits suffer from inelastic mechanical properties and especially poor surface biocompatibility, resulting in early loss of patency as a coronary graft. Approaches to manufacture an improved conduit using new polymers or polymer surfaces, acellular matrices, or cellular constructs have to date failed to achieve a commercially successful alternative. Elastin, by mimicking the native extracellular environment as well as providing elasticity, provides the 'missing link' in vascular conduit design and brings new hope for realization of the perfect conduit.
The chicken HPRT gene: a counter selectable marker for the DT40 cell line (1999)

We describe the cloning, characterisation and chromosomal mapping of the chicken hprt gene together with the construction of two counter selectable hprt-/- DT40 derived cell lines. One of these cell lines contains a stably integrated gene encoding a conditionally active cre recombinase and thus allows efficient manipulation of targeted loci by site-specific recombination. These cell lines will enhance the utility of the hyper-recombinogenic DT40 cell line as a system for the genetic analysis of cell autonomous functions in vertebrates and as a tool for mammalian chromosome engineering.
Real-Time Observations of Intracellular Mg<sup>2+</sup> Signaling and Waves in a Single Living Ventricular Myocyte Cell (2008)

Despite the important regulatory role of Mg(2+) in metabolic pathways, its underlying mechanism is not completely understood at the single-cell level. This study examined the propagation and dynamics of Mg(2+) signaling across the cell membrane by employing the real-time visualization of intracellular Mg(2+) waves in living ventricular myocytes using a combination of total internal reflection fluorescence microscopy and Nomarski differential interference contrast. Real-time Mg(2+) waves and sparks in a living cell membrane were observed using a fluorescent Mg(2+) indicator (mag-fluo-4-AM) in the concentration range of 5 aM-5 muM. The intracellular locations of the fluorescent Mg(2+) indicator were confirmed by adding Na(+)ATP. The Mg(2+) sparks and waves showed random temporal propagation patterns in nonhomogeneous substructures. These results show that spatiotemporal intracellular Mg(2+) signaling information can be obtained for individual living cells.
A cytokine, lymphocyte blastogenesis inhibitory factor (LBIF), arrests mitogen‐stimulated T lymphocytes at early G<sub>1</sub> phase with no influence on interleukin 2 production and interleukin 2 receptor light chain expression (1989)

The function of a human cytokine, lymphocyte blastogenesis inhibitory factor (LBIF), was characterized. To this end, LBIF was purified from crude supernatant of U-937 cells, a human macrophage-like cell line, by using fast protein liquid chromatography (FPLC). We demonstrated here that (a) the LBIF preparation completely inhibited phytohemagglutinin (PHA)-stimulated T cell proliferation; (b) however, in PHA-stimulated T lymphocytes LBIF inhibited neither interleukin (IL)2 production nor the expression of IL2 receptor (IL2R) light chain (CD25) which play a critical role for T cell proliferation; (c) LBIF arrested PHA-stimulated T lymphocytes at the G1 phase of cell cycle and inhibited entry into S phase, thus inhibiting lymphocyte proliferation. Wright-Giemsa's staining of the cells showed that PHA/LBIF-stimulated cells were arrested in early G1. In agreement with this result, LBIF strongly inhibited PHA-induced RNA synthesis. Further, LBIF inhibited the induction of the transferrin receptor which is normally expressed at the late G1 phase of the cell cycle. The inhibitory activity of LBIF was reversible. Thus, this study elucidated that LBIF arrests PHA-stimulated T lymphocytes at a point between the stages of IL2 production or IL2R light chain expression (in early G1) and transferrin receptor expression (in late G1). Taken together, these results suggest that there might be a control system of T cell proliferation distinct from the previously reported mechanisms, such as the inhibition of IL2 production or the inhibition of IL2R light chain (CD25) expression, and that LBIF might be an important molecule in the regulation of normal lymphocyte proliferation.
Correlation of Radiologist Rank as a Measure of Skill in Screening and Diagnostic Interpretation of Mammograms (2006)

The interpretive performance of radiologists among their peers is moderately correlated between screening and diagnostic interpretations. Thus, proficiency in one area does not guarantee proficiency in the other area for some radiologists.
Head pose estimation using isophote features for driver assistance systems (2009)

In this paper, we consider the problem of estimating the pose of a driver from video data. We propose to use isophote features to improve classification performance when illumination varies. In particular, we both use the direction and curvature features. The features are encoded into direction histogram and curvature histogram in the blocks of the image. Experimental results show that the proposed features could well describe the structure of driver face image, and have a good performance in real scene.
Cellular Site of Glucocorticoid-Receptor Complex Formation (1972)

The cellular site of binding of dexamethasone by specific glucocorticoid receptors in cultured hepatoma cells was investigated with the use of certain mercurials. p-Chloromercuribenzene sulfonate and p-chloromercuribenzoate inhibit the binding of steroid by receptors in cell-free extracts, but they allow the steroid-receptor complex to form in whole cells. In contrast, HgCl(2) inhibits binding both in extracts and cells. Since both organic mercury compounds, unlike HgCl(2), do not readily enter intact cells, it appears that the specific steroid binding occurs inside the cell rather than at the cell membrane.