gebhart/patrepeval huggingface dataset:
Treg inducing adjuvants for therapeutic vaccination against chronic inflammatory diseases (2013)

Many existing therapies in autoimmune diseases are based on systemic suppression of inflammation and the observed side effects of these therapies illustrate the pressing need for more specific interventions. Regulatory T-cells (Treg) are pivotal controllers of (auto-aggressive) immune responses and inflammation, and decreased Treg numbers and/or functioning have been associated with autoimmune disease. Therefore, Treg became frequently studied targets for more specific immunotherapy. Especially antigen-specific targeting of Treg would enable local and tailor made interventions, while obviating the negative side effect of general immuno-suppression. Self-antigens that participate in inflammation, irrespective of the etiology of the different autoimmune diseases, are held to be candidate antigens for antigen-specific interventions. Rather than tolerance induction to disease inciting self-antigens, which are frequently unknown, general self-antigens expressed at sites of inflammation would allow targeting of disease independent, but inflammatory-site specific, regulatory mechanisms. Preferably, such self-antigens should be abundantly expressed and up-regulated at the inflammatory-site. In this perspective heat shock proteins (Hsp) have several characteristics that make them highly attractive targets for antigen-specific Treg inducing therapy. The development of an antigen-specific Treg inducing vaccine is a major novel goal in the field of immunotherapy in autoimmune diseases. However, progress is hampered not only by the lack of effective antigens, but also by the fact that other factors such as dose, route, and the presence or absence of an adjuvant, turned out to be critical unknowns, with respect to the effective induction of Treg. In addition, the use of a Treg inducing adjuvant might be required to achieve an effective regulatory response, in the case of ongoing inflammation. Future goals in clinical trials will be the optimization of natural Treg expansion (or the induction of adaptive Treg) without loss of their suppressive function or the concomitant induction of non-regulatory T-cells. Here, we will discuss the potential use of protein/peptide-based vaccines combined with Treg inducing adjuvants for the development of therapeutic vaccines against chronic inflammatory conditions.
Group-Mobility-Aware Spectrum Management for Future Digital Battlefields (2006)

Efficient access to spectrum is critical to maintain reliable and robust communication in military networks, especially for ground vehicles on the move. High mobility and frequent topology variations make spectrum management in battlefields challenging. In this paper, we present a decentralized, hierarchical approach to assign spectrum channels among vehicles in a fair and efficient manner. Making use of group mobility, we propose a low-complexity allocation scheme with minimum communication and computation overhead. Experimental results demonstrate that the proposed algorithm can reduce the overhead by 10+ fold with maintaining reasonable spectrum utilization
凌力尔特:虽为“私有”却人人皆知 (2006)

虽然凌力尔特(Linear,原中文名称为:凌特。)只占全球模拟IC市场3％的份额,但是其高达40％的利润率却赢得了行业的很多尊重。《Electronic Business》杂志总编辑John Dodge采访了自从2005年1月以来担任凌力尔特首席执行官的Lothar Maier。Maier从公司创始人Bob Swanson手中接过这一重任,而后者是凌力尔特1981年成立以来唯一的一位首席执行官。该公司的产品包括放大器、电池管理设备、数据转换器、稳压器和电压基准等。
Prognostic Value of Proton Magnetic Resonance Spectroscopy in Ischemic Stroke (1998)

Single-voxel 1H-MRS performed during the acute or subacute phase of ischemic stroke may provide prognostic information.
Vivid Tumor Imaging Utilizing Liposome-Carried Bimodal Radiotracer (2014)

By developing a new bimodal radioactive tracer that emits both luminescence and nuclear signals, a trimodal liposome for optical, nuclear, and magnetic resonance imaging is efficiently prepared. Fast clearance of the radiotracer from reticuloendothelial systems enables vivid tumor imaging with minimum background.
Cotton Stretch Fabrics by Slack Mercerization: Part I: The Effects of Yarn and Fabric Construction (1963)

The unrestricted shrinkage of balanced plied yarns and singles yarns in sodium hydroxide solution of mercerizing strength was found to increase with increasing twist; the extent of shrinkage and rate of increase were higher for singles yarns than plied yarns. Plied yarns developed high tensions faster than singles yarns when mercerization was carried out without shrinkage. If shrinkages of more than 15% to 20% are permitted, the tension developed is almost too low to measure. This indicates that for fabrics that shrink more than 20% the forces that may cause additional shrinkage are very small and easily restricted. Twist had only minor effects on the shrinkage of the 72 fabrics of varying warp ends per inch and different yarn structure used in the experiments. Also the stretch properties were similar. Calculations of filling tightness, expressed as filling cover factor, indicate that a maximum of approximately 16 can be obtained by the slack mercerization of fabrics for filling stretch if the fabric shrinks more than 20%. The conversion of cellulose I to cellulose II is more dependent on the temperature of the wash water than on the amount of unrestricted shrinkage or duration of immersion. To obtain additional shrinkage in any fabric of a selected weight, it is apparently necessary to use weaves that promote increases in fabric thickness.
Modeling of nMOS transistors for simulation of hot-carrier-induced device and circuit degradation (1992)

The authors present an accurate one-dimensional device model for the simulation of nMOS transistors with hot-carrier-induced oxide damage. The model uses a realistic charge density distribution profile to account for the localization of the oxide-interface charge near the drain. Model simulation results obtained for nMOS transistors with hot-carrier-induced oxide damage demonstrate good agreement with the experimental data. The amount and the location of the hot-carrier-induced oxide damage are simulated by using only a few parameters, which simplifies the implementation of the model in a reliability simulation environment. The proposed model has been implemented in the iSMILE circuit simulator, and the capabilities of the model have been explored by various circuit simulation examples. The damaged-MOSFET model presented offers a simple and accurate approach for simulating the circuit behavior after hot-carrier damage.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Workload characterization and performance evaluation in a research environment (1982)

This paper describes the process of bench-marking the diverse research environment that constitutes the workload of VAX/VMS at the University Analysis and Control Center at North Carolina State University. The benchmarking process began with a study of the system load and performance characteristics over the six-month period from January to June of 1981. Statistics were compiled on the number of active users, CPU usage by individual accounts, and peak load periods. Individual users were interviewed to determine the nature and major computing characteristics of the research they were conducting on VAX. Information from all sources was compiled to produce a benchmark that closely paralleled actual system activity. An analytic model was introduced and used in conjunction with the benchmark data and hardware characteristics to derive performance measures for the system. Comparisons with measured system performance were conducted to demonstrate the accuracy of the model. The model was then employed to predict performance as the system workload was increased, to suggest improvements for the system, and to examine the effects of those improvements.
Impact of cystic fibrosis disease on archaea and bacteria composition of gut microbiota (2016)

Cystic fibrosis is often associated with intestinal inflammation due to several factors, including altered gut microbiota composition. In this study, we analyzed the fecal microbiota among patients with cystic fibrosis of 10-22 years of age, and compared the findings with age-matched healthy subjects. The participating patients included 14 homozygotes and 14 heterozygotes with the delF508 mutation, and 2 heterozygotes presenting non-delF508 mutations. We used PCR-DGGE and qPCR to analyze the presence of bacteria, archaea and sulfate-reducing bacteria. Overall, our findings confirmed disruption of the cystic fibrosis gut microbiota. Principal component analysis of the qPCR data revealed no differences between homozygotes and heterozygotes, while both groups were distinct from healthy subjects who showed higher biodiversity. Archaea were under the detection limit in all homozygotes subjects, whereas methanogens were detected in 62% of both cystic fibrosis heterozygotes and healthy subjects. Our qPCR results revealed a low frequency of sulfate-reducing bacteria in the homozygote (13%) and heterozygote (13%) patients with cystic fibrosis compared with healthy subjects (87.5%). This is a pioneer study showing that patients with cystic fibrosis exhibit significant reduction of H<sub>2</sub>-consuming microorganisms, which could increase hydrogen accumulation in the colon and the expulsion of this gas through non-microbial routes.
Eliminating inter-process cache interference through cache reconfigurability for real-time and low-power embedded multi-tasking systems (2007)

We propose a technique which leverages configurable data caches to address the problem of cache interference in multitasking embedded systems. Data caches are often necessary to provide the required memory bandwidth. However, caches introduce two important problems for embedded systems. Cache outcomes in multi-tasking environments are notoriously difficult to predict, if not impossible, thus resulting in poor real-time guarantees. Additionally, caches contribute to a significant amount of power. These issues are key factors for many embedded systems. We study the effect of multiple tasks on the data cache, and propose a technique which leverages configurable cache architectures to eliminate inter-task cache interference. By mapping tasks to different cache partitions, interference is completely eliminated with only a minimal impact on performance. Furthermore, dynamic and leakage power are significantly reduced as only a subset of the cache is active at any moment. We introduce a profile-based, static analysis algorithm, which identifies a beneficial cache partitioning. The OS configures the data cache during context-switch by activating the corresponding partition.Our experiments on a large set of multitasking benchmarks demonstrate that our technique not only efficiently eliminates inter-task interference but also significantly reduces both dynamic and leakage power.
Ab Initio Calculation of Vibrational Circular Dichroism Spectra of Chiral Natural Products Using MP2 Force Fields: Camphor (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAb Initio Calculation of Vibrational Circular Dichroism Spectra of Chiral Natural Products Using MP2 Force Fields: CamphorF. J. Devlin and P. J. StephensCite this: J. Am. Chem. Soc. 1994, 116, 11, 5003–5004Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/ja00090a062https://doi.org/10.1021/ja00090a062research-articleACS PublicationsRequest reuse permissionsArticle Views184Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Grid-connected inverter with inner output impedance and governor-free characteristics (2010)

This paper proposes for a PWM ac/dc inverter a new control algorithm that provides the inverter with both inner output impedance and governor-free characteristics. The proposed algorithm regulates the inverter as a voltage source all the time in not only standalone but grid-connected operations. The Park's equation of a synchronous machine is realized in a PWM inverter. The inner output impedance and the governor-free characteristics based on the algorithm are analyzed mathematically. The characteristic equations to design the inverter are derived through the analysis. Experimental results show that the measured values and the calculated values get in good agreement. The output voltage and current performance of the proposed inverter is characterized similarly to a synchronous machine without any compulsory control.
Management Education Collaboration Networks (2014)

Management education has come a long way since Sir Isaac Pitman initiated the first correspondence course in the early 1840s. Today the demands from a globalized economy are causing a sea change in the way business education is being delivered. The traditional one-size-fits-all educational approach of the past is being replaced with a customized and flexible learning paradigm that focuses on student outcomes and performance. Management education collaboration networks can assist in this transformation. A primary function of a collaboration network is to provide the management education community with access to curriculum innovation, databases, cloud computing resources, mobile learning technologies and implementation strategies. The network design should be based on stakeholder attitudes, new learning technologies, globalization, changing demographics and sustainability. The purpose of this article is to highlight the results of a global survey on collaboration networks and to outline the role of cloud-based collaboration in the future of business education.
The refinement of renewable resources: New important derivatives of fatty acids and glycerol (2010)

Abstract During the last years, the industrial significance of renewable resources has highly increased. The ever‐growing use of fossil resources for energy consumption, polymers, fine chemicals and pharmaceuticals and the therefore steadily increasing price favour the substitution of oil and gas by renewable resources. Here, especially products of catalytic functionalisations of vegetable fats and oils such as rapeseed oil, sunflower oil, palm oil or coconut oil play a decisive role. The present article gives a survey of several important catalytic functionalisations of fatty compounds and glycerol resulting in new attractive products. With their emerging properties, they could find a rapid introduction into the chemical market. Particularly the functionalisations via heterogeneous and homogeneous catalysis, like additions, reductions, oxidations and metathesis reactions, will be presented.
Charge localization or itineracy at<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mi mathvariant="normal">La</mml:mi><mml:mi mathvariant="normal">Al</mml:mi><mml:msub><mml:mi mathvariant="normal">O</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:mo>∕</mml:mo><mml:mi mathvariant="normal">Sr</mml:mi><mml:mi mathvariant="normal">Ti</mml:mi><mml:msub><mml:mi mathvariant="normal">O</mml:mi><mml:mn>3</mml:mn></mml:msub></mml:mrow></mml:math>interfaces: Hole polarons, oxygen vacancies, and mobile electrons (2006)

While correlated electron behavior is to be expected at oxide interfaces (IFs) involving Mott insulators, we show how strong correlations in the oxygen $2p$ states may be necessary to account for observed insulating behavior at charged (001)-IFs between the band insulators $\mathrm{La}\mathrm{Al}{\mathrm{O}}_{3}$ and $\mathrm{Sr}\mathrm{Ti}{\mathrm{O}}_{3}$. Using correlated band theory applied to the O $2p$ states, an insulating $p$-type IF is obtained only when a disproportionated, charge-, orbital-, and spin-ordered O ${P}_{\ensuremath{\pi}}$ magnetic hole is formed, centered between ${\mathrm{Al}}^{3+}$ ions in the $\mathrm{Al}{\mathrm{O}}_{2}$ layer at the IF. As an alternative explanation, charge compensation by oxygen vacancies that accommodate the holes as charge-conjugate F centers is modeled. For the $n$-type IF, a charge disproportionated ${\mathrm{Ti}}^{4+}+{\mathrm{Ti}}^{3+}$ layer is obtained with ferromagnetic alignment of the spins resulting from occupied ${d}_{xy}$ orbitals at checkerboard arranged ${\mathrm{Ti}}^{3+}$ sites. Electron hopping on a 50% occupied Ti sublattice (a quarter-filled band) and/or lattice relaxations are discussed as origin of the measured conductivity.
Reduced transport velocity of multiply scattered light due to resonant scattering (2006)

The transport properties of photons traveling through random media are of great fundamental and applied importance. For instance the dwell time due to resonant Mie scattering can lead to a significant reduction in transport velocity. Here, we have measured directly the energy-transport velocity of photons in strongly scattering media using a combination of time resolved transmission, measuring the diffusion coefficient, and angular resolved backscattering, yielding the transport mean free path. We find that the transport velocity is strongly reduced when the effective diameter of the scattering particles is a multiple of half the wavelength. This is consistent with the occurrence of resonant Mie scattering in the samples. We compare our data to previous theoretical calculations of the transport velocity as a function of scatterer size.
DNA sequence analysis of the inverted terminal repeats of a non-oncogenic avian adenovirus (1989)

Journal Article DNA sequence analysis of the inverted terminal repeats of a non-oncogenic avian adenovirus Get access Michael Sheppard, Michael Sheppard CSIRO, Division of Animal Health, Animal Health Research LaboratoryPrivate Bag No.l PO Parkville 3052,Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Katrina M. Emy Katrina M. Emy CSIRO, Division of Animal Health, Animal Health Research LaboratoryPrivate Bag No.l PO Parkville 3052,Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 17, Issue 10, 25 May 1989, Page 3995, https://doi.org/10.1093/nar/17.10.3995 Published: 25 May 1989 Article history Received: 09 March 1989 Published: 25 May 1989
Improvements in the calibration of<sup>109</sup>Cd K X-ray fluorescence systems for measuring bone lead in vivo (1994)

A 109Cd K x-ray fluorescence (XRF) system using a point source in a back-scatter geometry is described. The suitability of plaster-of-Paris phantoms as targets for intercalibration standards was evaluated. When the phantom concentrations were measured by inductively-coupled-plasma mass spectrometry (ICPMs), the calculated phantom concentrations underestimated true concentrations by an average of 15%. Since calculated values are used to calibrate the K XRF system, in vivo bone-lead concentrations may be similarly underestimated. The difference between calculated and measured concentration is attributable to impurities in the plaster of Paris (e.g. calcium carbonate). The ICPMS-measured concentrations were used to calibrate the K XRF system. The same phantoms were also measured as 'unknowns' by a bone-lead measurement system (Abiomed, Danvers, MA, USA). The commercial system overestimated the lowest-concentration phantoms and underestimated the phantoms with concentrations above 15 microg Pb/g plaster of Paris. The commercial system and our system were compared by measurement of the new phantoms in air and in water. The K XRF system exhibited better precision in both situations. On the basis of this work, we recommend that plaster-of-Paris phantoms used to calibrate K XRF measurement systems be analysed first by ICPMS or another valid analytical technique.
A Three-Dimensional Model-Based Inversion Algorithm Using Radial Basis Functions for Microwave Data (2012)

We present a three-dimensional (3D) model-based inversion algorithm for inverting electromagnetic data. In our approach, the models are described by points in the 3D space and the so-called radial basis functions are used as the interpolation functions for connecting these points. The use of the radial basis functions renders the surface of the target intrinsically smooth. The L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -norm and weighted L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -norm regularization schemes are employed to constrain the curvature and to further smooth the surface of the target. We tested this inversion algorithm using both synthetic and experimental data sets. The inversion results demonstrate that both the shapes and material properties of the target are well reconstructed. As a complementary algorithm to the pixel-based (tomographic) inversion algorithms, the model-based inversion algorithm has fewer parameters to invert; hence, it has a higher computational efficiency. The model-based inversion algorithm also gives the users the freedom to construct an initial model based on their knowledge and other related information. It helps to reduce the non-uniqueness in the data interpretation.
&#x201C;Inkjet-printed paper/polymer-based &#x201C;green&#x201D; RFID and wireless sensor nodes: The final step to bridge cognitive intelligence, nanotechnology and RF?&#x201D; (2010)

Summary form only given. In this talk, inkjet-printed flexible antennas, RF electronics and sensors fabricated on paper and other polymer (e.g.LCP) substrates are introduced as a system-level solution for ultra-low-cost mass production of UHF Radio Frequency Identification (RFID) Tags and Wireless Sensor Nodes (WSN) in an approach that could be easily extended to other microwave and wireless applications. The talk will cover examples from UHF up to the millimeter-wave frequency ranges. A compact inkjet-printed UHF “passive-RFID” antenna using the classic T-match approach and designed to match IC's complex impedance, is presented as a the first demonstrating prototype for this technology. Then, Prof. Tentzeris will briefly touch up the state-of-the-art area of fully-integrated wireless sensor modules on paper or flexible LCP and show the first ever 2D sensor integration with an RFID tag module on paper, as well as numerous 3D multilayer paper-based and LCP-based RF/microwave structures, that could potentially set the foundation for the truly convergent wireless sensor ad-hoc networks of the future with enhanced cognitive intelligence and “rugged” packaging. Prof. Tentzeris will discuss issues concerning the power sources of “near-perpetual” RF modules, including flexible minaturized batteries as well as power-scavenging approaches involving thermal, EM, vibration and solar energy forms. The final step of the presentation will involve examples from wearable (e.g. biomonitoring) antennas and RF modules, as well as the first examples of the integration of inkjet-printed nanotechnology-based (e.g.CNT) sensors on paper and organic substrates. It has to be noted that the talk will review and present challenges for inkjet-printed organic active and nonlinear devices as well as future directions in the area of environmentally-friendly (“green”) RF electronics and “smart-skin” conformal sensors.