gebhart/patrepeval huggingface dataset:
Pulmonary Microvascular Permeability (1995)

The pressure threshold for injury of pulmonary capillaries is approximately 50 to 55 cm H2O in the canine lung, as measured by changes in the filtration coefficient (Kf,c). Since the pulmonary endothelial basement membrane has been observed to thicken in patients with heart failure and pulmonary venous hypertension, we hypothesized that both baseline permeability and the threshold for high-vascular-pressure injury would be altered as a result. Dogs (n = 12) were chronically paced at 245 beats per minute for approximately 4 weeks, then were paced at 225 beats per minute for an additional 3 weeks. Lung lobes from anesthetized paced dogs and additional control dogs (n = 14) were then isolated, ventilated, and perfused with blood. Although vascular resistance was increased nearly threefold and vascular compliance reduced by 50% in the paced group, Kf,c referenced to 1 g blood-free dry weight was no different from control. Despite this lack of difference at normal pulmonary vascular pressures, several significant results were obtained. First, in the paced group there was a significant increase in the threshold for high-vascular-pressure injury: Kf,c measured at pulmonary vascular pressures commonly seen in heart failure (20 to 50 cm H2O) were significantly less in this group compared with control. Model predictions showed that in vivo, this difference in Kf,c would result in a 50% reduction in the amount of water and protein cleared across the pulmonary capillary endothelial barrier in the paced group.(ABSTRACT TRUNCATED AT 250 WORDS)
Near-infrared Raman spectroscopy for early diagnosis and typing of adenocarcinoma in the stomach (2010)

NIR Raman spectroscopy can detect gastric malignancy and identify the subtype of gastric adenocarcinoma.
Stimuli-Responsive Polymersomes for Biomedical Applications (2017)

Polymersomes, the structural analogues of liposomes, are hollow structures enclosed by a bilayer membrane made from amphiphilic copolymers. Polymersomes have been proposed to mimic the structure and properties of cellular membranes and viral capsids. Excellent robustness and stability, chemical versatility for tunable membrane properties and surface functionalization make polymersomes attractive candidates for drug delivery, diagnostic imaging, nanoreactor vessels, and artificial organelles. In further biomimetic strategies, stimuli-responsive polymersomes that can recognize various external physical or internal biological environmental stimuli and conduct "on demand" release in dose-, spatial-, and temporal-controlled fashions have been widely developed. This Perspective focuses on recent advances in stimuli-responsive polymersomes and their potential biomedical applications. Representative examples of each stimulus, the advantages and limitations of different strategies, and the future opportunities and challenges are discussed.
Synthesis of Enantiomerically Pure 1-(<i>R</i>)- and 1-(<i>S</i>)-Hydroxymethyl-Dtpa Penta-<i>t</i>-Butyl Esters<i>Via</i>Chiral Aminoalcohols (1996)

Abstract A convenient synthesis of enantiomerically enriched 1-hydroxymethyl-DTPA (diethylenetriamine pentaacetic acid) penta-t-butyl esters 3 has been achieved for the preparation of chiral synthones of new paramagnetic gadolinium complexes.
Quantization and Training of Neural Networks for Efficient Integer-Arithmetic-Only Inference (2018)

The rising popularity of intelligent mobile devices and the daunting computational cost of deep learning-based models call for efficient and accurate on-device inference schemes. We propose a quantization scheme that allows inference to be carried out using integer-only arithmetic, which can be implemented more efficiently than floating point inference on commonly available integer-only hardware. We also co-design a training procedure to preserve end-to-end model accuracy post quantization. As a result, the proposed quantization scheme improves the tradeoff between accuracy and on-device latency. The improvements are significant even on MobileNets, a model family known for run-time efficiency, and are demonstrated in ImageNet classification and COCO detection on popular CPUs.
Coronary Vasodilating Effect of Some Chromanone Derivatives (1972)

The effects of benzylidene chromanones and its related compounds on coronary and femoral blood flow were examined in anesthetized dogs. They exhibited vasodilating activity in both vascular beds, but less active than that of papaverine. Intravenous administration of 3-(4'-β-diethylaminoethoxy)-benzylidene chromanone HCl (CDY-902) caused an increase in coronary blood flow as well as a transient hypotension and persistent negative chronotropic action. No significant effect of CDY-902 on myocardial oxygen consumption of the dog in situ was observed. On oxygen uptake of the rat heart slices CDY-902 elicited a decrease similar to papaverine. As the results were compared with those of papaverine, GTN and dipyridamole, CDY-902 appears to have a direct and nonselective effects on coronary vascular bed.
Strength improvements through occlusal splints? The effects of different lower jaw positions on maximal isometric force production and performance in different jumping types (2018)

An influence of occlusion splints on rate of force development (RFD) and maximal strength tests could be confirmed. A small, but consistent increase in the performance parameters could be measured. The influence of the occlusion condition is most likely small compared to other influences as for example training status, age, gender and circadian rhythm.
Searching Ground States of Ising Spin Glasses with a Tree Bond-Based Representation (2008)

Ising spin glasses are a rich source of challenging highly multimodal optimization problems.The Ising model is one of the most widely used models for disordered systems in statistical physics.Finding the ground state of an Ising spin glass can be expressed as the problem of determining the minimum weighted cut in a graph.The classical approach when dealing with a spin glasses system is to encode the state of the system based on the states of spins.This paper presents a new representation for the states of Ising spin glasses based on the bonds between spins.This encoding is used with a specially designed Genetic Algorithm to search for low energy states of such systems, with the goal of finding ground states.To this end, special genetic operators are also defined and presented in detail in the paper.The results of preliminary experiments are very promising for this class of problems.
Corticolimbic anatomical characteristics predetermine risk for chronic pain (2016)

SEE TRACEY DOI101093/BRAIN/AWW147 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Mechanisms of chronic pain remain poorly understood. We tracked brain properties in subacute back pain patients longitudinally for 3 years as they either recovered from or transitioned to chronic pain. Whole-brain comparisons indicated corticolimbic, but not pain-related circuitry, white matter connections predisposed patients to chronic pain. Intra-corticolimbic white matter connectivity analysis identified three segregated communities: dorsal medial prefrontal cortex-amygdala-accumbens, ventral medial prefrontal cortex-amygdala, and orbitofrontal cortex-amygdala-hippocampus. Higher incidence of white matter and functional connections within the dorsal medial prefrontal cortex-amygdala-accumbens circuit, as well as smaller amygdala volume, represented independent risk factors, together accounting for 60% of the variance for pain persistence. Opioid gene polymorphisms and negative mood contributed indirectly through corticolimbic anatomical factors, to risk for chronic pain. Our results imply that persistence of chronic pain is predetermined by corticolimbic neuroanatomical factors.
Dependência e Desenvolvimento na América Latina despois da Reforma do Estado (2000)

This paper analizes the work of Fernando Henrique Cardoso and Enzo Faletto (Dependencia e Desenvolvimento), to see the relation between state and social classes in the brazilian development process, yersteday and today.
COMPARISON OF METHODS FOR RECORDING RESPIRATION IN NEWBORN INFANTS (1965)

The barometric method of Drorbaugh and Fenn for measuring respiratory rate and tidal volume in newborn infants has been compared by simultaneous recordings with an impedance pneumograph and a mercury-in-rubber strain gauge, using integrated flow rate measurements as the standard. The barometric method proved to be approximately as accurate as the others, but it allows the infant to be unrestricted with no interference by tactile stimulation during measurements, and it requires less instrumentation. Therefore a total body plethysmograph can be used confidently without additional equipment for intermittent recording of respiration in normal and diseased infants.
Ontologies for Model-Driven Business Transformation (2008)

Semantic markup languages such as RDF (resource description framework) and OWL (Web ontology language) are increasingly used to externalize metadata or ontology about business data, software, and services in a declarative form. Such externalized descriptions in ontological format are utilized for purposes ranging from search and retrieval to information integration and to business transformation. Ontology can significantly reduce the costs and improve the qualities of deploying, querying, integrating, and transforming enterprise systems. This chapter presents an innovative application of ontology to a model-driven approach to business analysis and transformation. The approach employs a daisy chain of business models for causality analyses. It links, by using semantic models, business processes and business components to IT solutions and capabilities at different phases of business transformation. The semantic models help infer causality of any business pain points and recommend appropriate solutions to fix business or IT shortfalls associated with the pain points in the process of business transformation. In addition, this chapter presents an enterprise-scale ontology management system which provides functionality, scalability, and performance demanded by enterprise applications such as the proposed model-driven business transformation. It describes the design and implementation of the management system which programmatically supports the ontology needs of business applications in a similar to that in which a database management system supports their data needs.
Central Role of Manganese in Regulation of Stress Responses, Physiology, and Metabolism in <i>Streptococcus pneumoniae</i> (2010)

ABSTRACT The importance of Mn 2+ for pneumococcal physiology and virulence has been studied extensively. However, the specific cellular role(s) for which Mn 2+ is required are yet to be fully elucidated. Here, we analyzed the effect of Mn 2+ limitation on the transcriptome and proteome of Streptococcus pneumoniae D39. This was carried out by comparing a deletion mutant lacking the solute binding protein of the high-affinity Mn 2+ transporter, pneumococcal surface antigen A (PsaA), with its isogenic wild-type counterpart. We provide clear evidence for the Mn 2+ -dependent regulation of the expression of oxidative-stress-response enzymes SpxB and Mn 2+ -SodA and virulence-associated genes pcpA and prtA . We also demonstrate the upregulation of at least one oxidative- and nitrosative-stress-response gene cluster, comprising adhC , nmlR , and czcD , in response to Mn 2+ stress. A significant increase in 6-phosphogluconate dehydrogenase activity in the psaA mutant grown under Mn 2+ -replete conditions and upregulation of an oligopeptide ABC permease (AppDCBA) were also observed. Together, the results of transcriptomic and proteomic analyses provided evidence for Mn 2+ having a central role in activating or stimulating enzymes involved in central carbon and general metabolism. Our results also highlight the importance of high-affinity Mn 2+ transport by PsaA in pneumococcal competence, physiology, and metabolism and elucidate mechanisms underlying the response to Mn 2+ stress.
Long and short forms of the ovine prolactin receptor: cDNA cloning and genomic analysis reveal that the two forms arise by different alternative splicing mechanisms in ruminants and in rodents (1997)

Prolactin is a pituitary hormone that binds to specific receptors in numerous tissues. Depending on the size of their cytoplasmic domain, long and short prolactin receptors (l-PR, s-PR) have been described. Up to now, s-PR were found in rodents only. We report here the cloning of full-length coding sequences for short and long ovine prolactin receptors (s-oPR, l-oPR). The only difference between s- and l-oPR coding sequences was, respectively, the presence or absence of a 39 base pair insert at the beginning of the cytoplasmic domain, with two contiguous inframe stop codons at its 3' end. Sequence comparison revealed that the alternative splicing producing s- and l-oPR was different from that of rodents, although the resulting proteins were very similar. PCR experiments on ovine genomic DNA showed that the 39 base pair insert was directly linked to the downstream exon, and separated from the upstream exon by an 800 base pair intron. Thus, the alternative splicing used a single intron with one 5' and two 3' sites. The same organization was found in bovine and caprine genomes, suggesting that this feature is general in ruminants and different from rodents, which use mutually exclusive exons to produce s-PR and l-PR.
Spectral estimation using a log-distance error criterion applied to speech recognition (2003)

A novel algorithm is presented for the estimation of a signal in noise. The distortion criterion used is based on the distance between log spectra. In many signal-processing applications, such as speech recognition, log spectra are much closer to the parameters used in a discriminator than power spectra. Therefore, it is believed that this spectral estimation technique should lead to better results than previously developed techniques such as spectral subtraction. The present technique performed better than spectral subtraction in noise immunity experiments on the IBM isolated word speech-recognition system, although at the expense of additional computational requirements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Screening and evaluation of human single-chain fragment variable antibody against hepatitis B virus surface antigen. (2006)

The anti-HBsAg ScFv successfully produced by phage antibody technology may be useful for broadening the scope of application of the antibody.
Customizable Web-Based System to Federate Smart Devices and Peripherals (2014)

Smart devices such as smartphones and tablets are increasingly essential tools to make our lives more convenient. Wearable devices and ambient devices are also getting popular and can easily access the Internet through smart devices. Although smart devices have incredibly advanced functionalities, their I/O is poor because of their small size. Peripherals are able to compensate for the shortcomings, but currently there is no unified methodology to gather and integrate given devices. We have developed a customizable Web-based system in which services in the Cloud can federate smart devices and peripherals. The proposed system uses Web based technologies to coordinate between cloud services and the devices at hand. The main benefit is that Web application developers can create an entire system since the configuration and operation of all devices are describable only in JavaScript. We have also separated the device functionality from the application logic, thus enabling parallel development. We implemented a prototype system using Bluetooth low energy (BLE) and found that it could be easily used to develop a system that emulates a POS terminal. The proposed architecture enables developers to flexibly utilize the Web of Things.
Gene Transfer to Liver Cancer Cells of B7-1 Plus Interleukin 12 Changes Immunoeffector Mechanisms and Suppresses Helper T Cell Type 1 Cytokine Production Induced by Interleukin 12 Alone (2000)

To investigate the cooperative effect of B7-1 and IL-12 in the induction of antitumor activity, we have developed retroviral vectors encoding human B7-1, murine IL-12, or both B7-1 and IL-12 coordinately. Murine transformed liver cells (BNL) were engineered to stably express B7-1, IL-12, or both by infection with corresponding retroviruses. No tumor was observed in 20, 75, and 95% of mice receiving, respectively, B7-1-, IL-12-, and B7-1/IL-12-modified tumor cells after 250 days of inoculation. In contrast, injection of parental BNL or BNL/Neo cells resulted in lethal tumor progression in all mice. Protection against rechallenge with parental tumor cells was observed only in mice who had rejected BNL/IL-12, but not in animals that rejected BNL/B7-1 or BNL/B7-1-IL-12. Growth of parental tumor cells was significantly delayed by simultaneous injection in a distant site of irradiated tumor cells engineered to express IL-12 or both B7-1 and IL-12 but not B7-1 alone. BNL/B7-1 and BNL/B7-1-IL-12 showed similar efficacy in these experiments. Antitumor immunity induced by B7, with or without IL-12, was found to depend mainly on CD4+ T cells with a minor contribution of a non-T cell mechanism; whereas the effect of IL-12 was dependent on CD8+ T cells and on non-T cell effectors. Immunization of mice with IL-12-modified BNL cells induced secretion of a Thl pattern of cytokines while immunization with cells expressing both IL-12 and B7-1 resulted in inhibition of IFN-gamma production. Immunization with BNL/B7-1-IL-12 cells in the presence of anti-human B7-1 MAb resulted in restoration of IFN-gamma production to the levels found in animals injected with BNL/IL-12 cells. To summarize, in our model coexpression of B7-1 and IL-12 in tumor cells does not result in improved antitumoral activity as compared with expression of IL-12 alone. This may be related to the fact that B7-1 changes the mechanisms of antitumor immunity and inhibits IFN-gamma production induced by IL-12 in vivo.
Assembly of chick brain MAP2-tubulin microtubule protein. Characterization of the protein and the MAP2-dependent addition of tubulin dimers (1991)

The principle proteins present in twice-cycled chick brain microtubule protein were characterized. The protein consists of a stoichiometric mixture of MAP2 and tubulin, together with a number of minor components. Its composition remains unaltered after a third cycle of assembly in a buffer supplemented with 67 mM-NaCl, with the exception of the phosphorylation of MAP2 to a low level (congruent to 1 mol.mol-1). The inclusion of 67 mM-NaCl dissociates the MAP2-tubulin oligomers, and restricts the assembly to the MAP2-dependent addition and loss of tubulin dimers, such that the assembly kinetics approximate to a simple pseudo-first-order reaction. The assembled microtubules exhibit dynamic instability, with no evidence for end-to-end annealing.
A Domain Ontology-based Navigation Learning System (2008)

This paper focuses on the design and implementation of a domain ontology-based navigation learning system, which can guide the user to learn more efficiently. Aiming at improving users' conceptual understanding of course material, a navigation structure was built among concepts, and each concept is presumed to have at least one concept instance which is provided by a Web answer system based on natural language which was integrated in this system. Then users would browse through the linked resources under those particular concepts as well as related concepts and get a better understanding of the material in the course. The kernel of such function was a domain knowledge base which was composed of concepts and relationship between them. Ontology was introduced as a mechanism to guide the establishment of this base. At last, a method of extracting concepts and relationship between them by using machine learning algorithms were presented.
Les états de l’adverbe, Guimier, Claude et Pierre Larcher éd., 1991, travaux linguistiques du CERLICO, n 3, Rennes (France), Presses universitaires de Rennes 2, 197 p. L’adverbe dans tous ses états, Guimier, Claude et Pierre Larcher éd., 1991, travaux linguistiques du CERLICO, n 4, Rennes (France), Presses universitaires de Rennes 2, 204 p. (1992)

Les états de l’adverbe, Guimier, Claude et Pierre Larcher éd., 1991, travaux linguistiques du CERLICO, no 3, Rennes (France), Presses universitaires de Rennes 2, 197 p. / L’adverbe dans tous ses états, Guimier, Claude et Pierre Larcher éd., 1991, travaux linguistiques du CERLICO, no 4, Rennes (France), Presses universitaires de Rennes 2, 204 p.. Un article de la revue Revue québécoise de linguistique (Morphologie) diffusée par la plateforme Érudit.
CHAOTIC SYNCHRONIZATION OF GLOBALLY COUPLED MAPS WITH AN APPLICATION IN COMMUNICATION (1996)

First, we consider a globally coupled map (GCM) where each subsystem has different dynamics from the others, and show two GCMs are synchronized chaotically by using Wu and Chua’s method. In the synchronized GCM, only the corresponding subsystems are synchronized. Next, we propose a method for a chaos time division multiple access communication using chaotically synchronized GCMs. Each channel has different chaos dynamics, and the information signals are masked chaotically. The corresponding channel can recover the information signals while other channels cannot.
Hyperspectral image target detection based on exponential smoothing method (2015)

In this paper, we proposed a new hyperspectral image target detector based on time series analysis, named as Exponential Smoothing Target Detector (ES-TD). As a classical method of time series analysis, the exponential smoothing method can choose the motional weight in the different part of data, which accelerates the reconstruction and forecast of the unknown data. The proposed method has a three-step process. Firstly, we select the applicable smoothing parameter according to the shape of the data curve. Then, given the reference and test spectral curves, we use the exponential smoothing method to obtain two new smoothing curves. Finally, we calculate the similarity between the two smoothing curves using SAM to determine whether the test spectral curve is the target or not. The proposed method has the feature of high computational efficiency and robustness. Experimental results on two real hyperspectral data sets demonstrate the advantages of the new method.
Generalized Mandelbrot rule for fractal sections (1992)

Mandelbrot's rule for sections is generalized to apply to the Hentschel and Procaccia fractal dimension at arbitrary q and on arbitrary sections. It is shown that for almost all (n-m)-dimensional sections, ${\mathit{D}}^{\mathit{n}}$(q)=${\mathit{D}}^{\mathit{n}\mathrm{\ensuremath{-}}\mathit{m}}$(q)+m, where the ${\mathit{D}}^{\mathit{r}}$(q) are box-counting, Hentschel, and Procaccia generalized fractal dimensions of r-dimensional sections of homogeneous fractal point sets in ${\mathit{R}}^{\mathit{n}}$ and ${\mathit{D}}^{\mathit{n}\mathrm{\ensuremath{-}}\mathit{m}}$(q)>0. The rule applies for finite ``thickness'' sections as well as ``true'' sections and can be interpreted for inhomogenous fractal sets.
Improvement of the CdTe diode detectors (2004)

Recent results from the CdTe Schottky diode detectors employing a guard-ring electrode are reported. Cathode electrode, made of Pt, was separated into an active electrode(s) and a surrounding guard-ring. Typical leakage current of a device with an active area of 2 /spl times/ 2 mm/sup 2/ and 0.5 mm thickness surrounded by a guard-ring, is 7 pA and 20 pA at a bias of 100 V and 500 V, respectively, operated at 20 /spl deg/C . Spectral resolution of this device is 0.93 keV and 1.2 keV (FWHM) at 59.5 keV and 122 keV, respectively, operated at 20 /spl deg/C with a bias of 800 V. Detailed study of the characteristics of these devices working as a gamma-ray detector is presented.