gebhart/patrepeval huggingface dataset:
Eine allgemein anwendbare, praxisnahe Methode zur Bestimmung der biologischen Abbaubarkeit wasserlöslicher organischer Stoffe (1974)

Article Eine allgemein anwendbare, praxisnahe Methode zur Bestimmung der biologischen Abbaubarkeit wasserlöslicher organischer Stoffe was published on July 1, 1974 in the journal Tenside Surfactants Detergents (volume 11, issue 4).
Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells (2015)

Taken together, our results suggest that beta-cells secrete microRNAs that can be transferred to neighboring beta-cells. Exposure of donor cells to pathophysiological conditions commonly associated with diabetes modifies the release of microRNAs and affects survival of recipient beta-cells. Our results support the concept that exosomal microRNAs transfer constitutes a novel cell-to-cell communication mechanism regulating the activity of pancreatic beta-cells.
Down-Regulation of Glycosylphosphatidylinositol-Specific Phospholipase D Induced by Lipopolysaccharide and Oxidative Stress in the Murine Monocyte- Macrophage Cell Line RAW 264.7 (2001)

Serum glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) activity is reduced over 75% in systemic inflammatory response syndrome. To investigate the mechanism of this response, expression of the GPI-PLD gene was studied in the mouse monocyte-macrophage cell line RAW 264.7 stimulated with lipopolysaccharide (LPS; 0.5 to 50 ng/ml). GPI-PLD mRNA was reduced approximately 60% in a time- and dose-dependent manner. Oxidative stress induced by 0.5 mM H(2)O(2) or 50 microM menadione also caused a greater than 50% reduction in GPI-PLD mRNA. The antioxidant N-acetyl-L-cysteine attenuated the down-regulatory effect of H(2)O(2) but not of LPS. Cotreatment of the cells with actinomycin D inhibited down-regulation induced by either LPS or H(2)O(2). The half-life of GPI-PLD mRNA was not affected by LPS, or decreased slightly with H(2)O(2), indicating that the reduction in GPI-PLD mRNA is due primarily to transcriptional regulation. Stimulation with tumor necrosis factor alpha (TNF-alpha) resulted in approximately 40% reduction in GPI-PLD mRNA in human A549 alveolar carcinoma cells but not RAW 264.7 cells, suggesting that alternative pathways could exist in different cell types for down-regulating GPI-PLD expression during an inflammatory response and the TNF-alpha autocrine signaling mechanism alone is not sufficient to recapitulate the LPS-induced reduction of GPI-PLD in macrophages. Sublines of RAW 264.7 cells with reduced GPI-PLD expression exhibited increased cell sensitivity to LPS stimulation and membrane-anchored CD14 expression on the cell surface. Our data suggest that down-regulation of GPI-PLD could play an important role in the control of proinflammatory responses.
Power-aware technology mapping for LUT-based FPGAs (2003)

We present a new power-aware technology mapping technique for LUT-based FPGAs which aims to keep nets with high switching activity out of the FPGA routing network and takes an activity-conscious approach to logic replication. Logic replication is known to be crucial for optimizing depth in technology mapping; an important contribution of our work is to recognize the effect of logic replication on circuit structure and to show its consequences on power. In an experimental study, we examine the power characteristics of mapping solutions generated by several publicly available technology mappers. Results show that for a specific depth of mapping solution, the power consumption can vary considerably, depending on the technology mapping approach used. Furthermore, results show that our proposed mapping algorithm leads to circuits with substantially less power dissipation than previous approaches.
Thermal Decomposition of Hydrazine. (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal Decomposition of Hydrazine.H. W. LucienCite this: J. Chem. Eng. Data 1961, 6, 4, 584–586Publication Date (Print):October 1, 1961Publication History Published online1 May 2002Published inissue 1 October 1961https://pubs.acs.org/doi/10.1021/je60011a030https://doi.org/10.1021/je60011a030research-articleACS PublicationsRequest reuse permissionsArticle Views2614Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nucleophilic Acylation of <i>o-</i>Quinone Methides:  An Umpolung Strategy for the Synthesis of α-Aryl Ketones and Benzofurans (2007)

The synthesis of α-aryl ketones is accomplished by the direct nucleophilic acylation of o-quinone methide electrophiles. In this process, two reactive intermediates, carbonyl anions and o-quinone methides, are generated in one flask upon treatment of the corresponding thiazolium carbinols and silyl protected phenols with a soluble fluoride source. These intermediates then undergo productive addition reactions to afford the desired α-aryl ketone adducts. This new strategy has been applied to a short synthesis of the natural product demethylmoracin I.
Comparison of the kinetics of glyburide and its active metabolites in humans (1995)

The pharmacokinetics of glyburide (Gb) and its active metabolites, 4-trans-hydroxyglibenclamide (M1) and 3-cis-hydroxyglibenclamide (M2), were compared in eight healthy subjects. After an overnight fast, each subject received a 3.5-mg single dose of Gb, M1 or M2 intravenously in random cross-over order. For comparison, a 3.5-mg oral dose of micronized formulation of Gb was also given in a test. The subjects continued to fast until standard meals were given at 0.5 and 5.5 h after each dose. Serum samples and urine fractions were collected for 10 h. Serum concentrations of Gb, M1 and M2, and urine concentrations of M1 and M2 were determined by a selective and sensitive liquid chromatographic method. The two metabolites had very similar pharmacokinetic profiles, except for volume of distribution and renal clearance. Estimated mean volume of distribution, total and renal clearance of M1 and M2 were 20.8 +/- 8.4 litres, 11.9 +/- 1.7 litres/h, 13.5 +/- 3.7 litres/h and 15.5 +/- 5.5 litres, 10.4 +/- 1.3 litres/h, 8.6 +/- 1.6 litres/h, respectively. Estimates of the volume of distribution and total clearance were significantly higher than those of Gb, which were 7.44 +/- 1.53 litres, 4.42 +/- 0.56 litres/h intravenously and 9.32 +/- 2.79 litres, 4.09 +/- 0.45 litres/h orally. There was no significant difference in total metabolite urine recovery between intravenous or oral administration of Gb, suggesting almost complete oral bioavailability of the micronized glibenclamide formulation.
Non-ionic contrast media in acrylic bone cement (2005)

Non-ionic, water-soluble, contrast media, iohexol and/or iodixanol, have been investigated for use in acrylic bone cement aimed for arthroplasty. Bone cement, containing the new particulate contrast media , was investigated for: quasi-static mechanical properties, water uptake properties, release of contrast media from the bone cement, biological responses from particulate bone cement, polymerisation reaction, polymerisation temperature, glass transition temperature, injectability and penetration into human cancellous bone, and radiopacity. The quasi-static mechanical properties of acrylic bone cement are influenced by the size and amount of contrast media in the bone cement; the particle size of iodixanol should be above 8 µm in order to have good mechanical properties. At a ratio of 8 wt%, good tensile strength is achieved while creating clear images on a standard X-ray. The molecular weight and glass transition temperature of the cement are not affected by the addition of iodixanol; however, iodixanol does lower the maximum polymerisation temperature. Both iohexol and iodixanol show better biocompatibility than conventional contrast medium; cement particles with iodixanol induce higher bone resorption in vitro than particles with iohexol, and there is a trend that particles with iodixanol show increased bone formation compared to particles with iohexol. The release of iohexol or iodixanol from wet bone cement does not result in a discernable radiolucent zone in the bone cement. The water uptake of cement containing iohexol is significantly higher than that of cement containing iodixanol, which shows higher water uptake than Palacos R. High viscosity cement (Palacos R) achieves better penetration into human cancellous bone in femoral heads than low viscosity cement (Osteopal). Cement containing iodixanol achieves higher bone cement penetration and injectability than low viscosity cement, but lower than Palacos R. The attenuation of X-rays in a contrast medium should be investigated in a standardised way using clinically relevant exposures. Therefore, the attenuation of bone cements (for use in hip- or knee- operations) should be investigated using an X-ray tube voltage of 70 ? 80 kV, with 0.1 m of water as a soft tissue phantom. At 80 kV, with water (similar to clinical situations), iodixanol attenuates photons to the same degree as equal amounts of ZrO2.
Infrared spectral histopathology for cancer diagnosis: a novel approach for automated pattern recognition of colon adenocarcinoma (2014)

Histopathology remains the gold standard method for colon cancer diagnosis. Novel complementary approaches for molecular level diagnosis of the disease are need of the hour. Infrared (IR) imaging could be a promising candidate method as it probes the intrinsic chemical bonds present in a tissue, and provides a "spectral fingerprint" of the biochemical composition. To this end, IR spectral histopathology, which combines IR imaging and data processing techniques, was employed on seventy seven paraffinized colon tissue samples (48 tumoral and 29 non-tumoral) in the form of tissue arrays. To avoid chemical deparaffinization, a digital neutralization of the spectral interference of paraffin was implemented. Clustering analysis was used to partition the spectra and construct pseudo-colored images, for assigning spectral clusters to various tissue structures (normal epithelium, malignant epithelium, connective tissue etc.). Based on the clustering results, linear discriminant analysis was then used to construct a stringent prediction model which was applied on samples without a priori histopathological information. The predicted spectral images not only revealed common features representative of the colonic tissue biochemical make-up, but also highlighted additional features like tumor budding and tumor-stroma association in a label-free manner. This novel approach of IR spectral imaging on paraffinized tissues showed 100% sensitivity and allowed detection and differentiation of normal and malignant colonic features based purely on their intrinsic biochemical features. This non-destructive methodology combined with multivariate statistical image analysis appears as a promising tool for colon cancer diagnosis and opens up the way to the concept of numerical spectral histopathology.
Microscopic imaging of residual stress using a scanning phase-measuring acoustic microscope (1989)

A high-resolution scanning phase-measuring acoustic microscope (SPAM) has been developed and used to image the near-surface residual stress field around features etched in sputtered alumina via the acoustoelastic effect. This microscope operates at 670 MHz and has a resolution of 5–10 μm, depending upon the amount of defocus. Relative velocity changes of sample surface waves as small as 50 ppm are resolved. Images of the stress field at the tip of a 400-μm-wide slot etched in alumina are presented and compared with a finite element simulation. The SPAM uses an unconventional acoustic lens with an anisotropic illumination pattern which can measure anisotropic effects and map residual stress fields with several μm resolution and a stress sensitivity of 1/3 MPa in an alumina film.
Nanoparticle Film Assemblies as Platforms for Electrochemical Biosensing—Factors Affecting the Amperometric Signal Enhancement of Hydrogen Peroxide (2013)

Factors affecting the enhanced amperometric signal observed at electrodes modified with polyelectrolyte-gold nanoparticle (Au-NP) composite films, which are potential interfaces for first-generation biosensors, were systematically investigated and optimized for hydrogen peroxide (H2O2) detection. Polyelectrolyte multilayer films embedded with citrate-stabilized gold nanoparticles exhibited high sensitivity toward the oxidation of H2O2. From this Au-NP film assembly, the importance of Au-NP ligand protection, film permeability, the density of Au-NPs within the film, and electronic coupling between Au-NPs (interparticle) and between the film and the electrode (interfacial) were evaluated. Using alternative Au-NPs, including those stabilized with thiols, polymers, and bulky ligands, suggests that the amperometric enhancement of H2O2 is optimized at poly-L-lysine-linked film assemblies embedded with Au-NPs possessing small, charged, and conductive (conjugated) peripheral ligands. As a potential application of these Au-NP film assemblies, an enhanced amperometric signal for H2O2 oxidation was shown for modified "needle" electrodes. The overall aim of this research is to gain a greater understanding of designing electrochemical sensing strategies that incorporate Au-NPs and target specific analytes.
A control scheme for automatic path tracking of vehicles subject to wheel slip constraint (2004)

We present a control scheme for automatic path tracking of a four-wheeled steering and four-wheeled drive (4WS4WD) vehicle subject to wheel slip constraint. The wheel slip, containing wheel slip ratio in longitudinal direction and slip angle in lateral direction, is a vector that serves as an index to avoid the tire-road friction saturation. Using linearization and singular perturbation theory, a linear and order-reduced design model is obtained, and the wheel slip is replaced by its quasi-steady state for the controller design. We propose a control structure of wheel torque and steering to transform the original tracking problem to a problem of state regulation subject to input constraint. A low-and-high gain technique is applied to construct the constrained controller and to enhance the utilization of the constrained wheel slip. Simulation shows that the new proposed control, scheme subject to wheel slip constraint coordinates well between wheel steering and wheel torque during tracking.
The Chemistry of Water on Alumina Surfaces: Reaction Dynamics from First Principles (1998)

Aluminas and their surface chemistry play a vital role in many areas of modern technology. The behavior of adsorbed water is particularly important and poorly understood. Simulations of hydrated alpha-alumina (0001) surfaces with ab initio molecular dynamics elucidate many aspects of this problem, especially the complex dynamics of water dissociation and related surface reactions. At low water coverage, free energy profiles established that molecularly adsorbed water is metastable and dissociates readily, even in the absence of defects, by a kinetically preferred pathway. Observations at higher water coverage revealed rapid dissociation and unanticipated collective effects, including water-catalyzed dissociation and proton transfer reactions between adsorbed water and hydroxide. The results provide a consistent interpretation of the measured coverage dependence of water heats of adsorption, hydroxyl vibrational spectra, and other experiments.
Antibacterial Effect of Photosensitizing Dyes on Xanthomonas oryzae, Leaf Blight Bacteria of Rice Plant Part I (1966)

760種類の感光色素について稲白葉枯病菌に対するin vitroの抗菌力を試験した結果, 205種類の色素が有効であった.その中で4種類の色素は0.1μg/mlの濃度でXanthomonas ovyzaeの生育を完全に阻止した.有効であった感光色素は, 4級窒素を含む複素環核と3級窒素を含む複素環核, benzopyran核, aminostyryl構造とをそれぞれmethine鎖で連結した型の色素であった.これらの試験結果から,供試感光色素の化学構造と抗菌性の関係について考察を行なった.また温室内で稲白葉枯病防除試験を行なった結果,数種類の感光色素が高い防除効果を示した.
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB <sub>1</sub> Receptor Knockout Mice (1999)

The function of the central cannabinoid receptor (CB1) was investigated by invalidating its gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of the CB1 receptor in mediating analgesia, reinforcement, hypothermia, hypolocomotion, and hypotension. The acute effects of opiates were unaffected, but the reinforcing properties of morphine and the severity of the withdrawal syndrome were strongly reduced. These observations suggest that the CB1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior.
Localization and characterization of specific receptors for atrial natriuretic factor in the ciliary processes of the eye (1986)

By light and electron microscope radioautography in vivo, competitive binding sites for 125I-Arg 101-Tyr 126 atrial natriuretic factor were localized mostly on the "pigmented" epithelium of the rat ciliary process. Further investigation using isolated ciliary processes from rabbits demonstrated the presence of specific receptors for 125I-atrial natriuretic factor. In addition, synthetic atrial natriuretic factor inhibited basal and stimulated adenylate cyclase activity. These results demonstrate for the first time the presence of specific receptors for atrial natriuretic factor in the ciliary processes which are negatively coupled to adenylate cyclase. The possible role of this peptide in the control of intraocular pressure is suggested.
Long-Range Triplet Energy Transfer between Metallointercalators Tethered to DNA:  Importance of Intercalation, Stacking, and Distance (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTLong-Range Triplet Energy Transfer between Metallointercalators Tethered to DNA: Importance of Intercalation, Stacking, and DistanceR. Erik Holmlin, Ricky T. Tong, and Jacqueline K. BartonView Author Information Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125 Cite this: J. Am. Chem. Soc. 1998, 120, 37, 9724–9725Publication Date (Web):September 9, 1998Publication History Received23 June 1998Published online9 September 1998Published inissue 1 September 1998https://pubs.acs.org/doi/10.1021/ja982187ohttps://doi.org/10.1021/ja982187orapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views370Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Charge transfer,Genetics,Molecular structure,Quantum mechanics,Quenching Get e-Alerts
UV photodetectors based on Al x Ga 1-x N grown by MOCVD (1996)

Metalorganic chemical vapor deposition was used to deposit Al<SUB>x</SUB>Ga<SUB>1-x</SUB>N active layers with varying aluminum compositions on basal plane sapphire substrate. Al<SUB>x</SUB>Ga<SUB>1-x</SUB>N (x < 0.5) ultraviolet photodetectors have been fabricated and characterized with cut-off wavelengths as short as 260 nm. Carrier lifetimes on the order of 10 milliseconds were estimated from frequency dependent measurements of the responsivity.
M2DP: A novel 3D point cloud descriptor and its application in loop closure detection (2016)

In this paper, we present a novel global descriptor M2DP for 3D point clouds, and apply it to the problem of loop closure detection. In M2DP, we project a 3D point cloud to multiple 2D planes and generate a density signature for points for each of the planes. We then use the left and right singular vectors of these signatures as the descriptor of the 3D point cloud. Our experimental results show that the proposed algorithm outperforms state-of-the-art global 3D descriptors in both accuracy and efficiency.
Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines (2015)

Exosomes are important mediators in cell-to-cell communication and, recently, their role in melanoma progression has been brought to light. Here, we characterized exosomes secreted by seven melanoma cell lines with varying degrees of aggressivity. Extensive proteomic analysis of their exosomes confirmed the presence of characteristic exosomal markers as well as melanoma-specific antigens and oncogenic proteins. Importantly, the protein composition differed among exosomes from different lines. Exosomes from aggressive cells contained specific proteins involved in cell motility, angiogenesis, and immune response, while these proteins were less abundant or absent in exosomes from less aggressive cells. Interestingly, when exposed to exosomes from metastatic lines, less aggressive cells increased their migratory capacities, likely due to transfer of pro-migratory exosomal proteins to recipient cells. Hence, this study shows that the specific protein composition of melanoma exosomes depends on the cells' aggressivity and suggests that exosomes influence the behavior of other tumor cells and their microenvironment.
Bioinspired turbine blades offer new perspectives for wind energy (2017)

Wind energy is becoming a significant alternative solution for future energy production. Modern turbines now benefit from engineering expertise, and a large variety of different models exists, depending on the context and needs. However, classical wind turbines are designed to operate within a narrow zone centred around their optimal working point. This limitation prevents the use of sites with variable wind to harvest energy, involving significant energetic and economic losses. Here, we present a new type of bioinspired wind turbine using elastic blades, which passively deform through the air loading and centrifugal effects. This work is inspired from recent studies on insect flight and plant reconfiguration, which show the ability of elastic wings or leaves to adapt to the wind conditions and thereby to optimize performance. We show that in the context of energy production, the reconfiguration of the elastic blades significantly extends the range of operating regimes using only passive, non-consuming mechanisms. The versatility of the new turbine model leads to a large increase of the converted energy rate, up to 35%. The fluid/elasticity mechanisms involved for the reconfiguration capability of the new blades are analysed in detail, using experimental observations and modelling.