gebhart/patrepeval huggingface dataset:
Powder Layer Preparation Using Vibration-controlled Capillary Steel Nozzles for Additive Manufacturing (2014)

In this report, the dry delivery of polyamide 12 powders by vibrating capillary steel nozzles is investigated and discussed regarding its potential for powder layer preparation in Laser Beam Melting. Therefore, a setup including a steel nozzle assembled on a piezoelectric actuator is presented, which enables the precise control over very small powder quantities by vibration excitation. An analysis reveals that the mass flow through the nozzle can be adjusted by the vibration modes in a certain range depending on the nozzle's specifications, whereas the vibration modes themselves show a complicated behaviour. Using a positioning system in combination with the vibrating nozzle, single-layer patterns consisting of polyamide 12 are produced and characterized regarding surface homogeneity and selectivity using a laser stripe sensor.
Gastrointestinal absorption of drugs: methods and studies (1999)

Physico-chemical descriptors of drug molecules are often not adequate in predicting their oral bioavailability. In vitro methods can be useful in evaluating some of the different factors contributing to bioavailability. While physical parameters such as drug solubility may effect oral bioavailability, in most cases, the major determining factors are likely to be metabolism, and absorption at the intestinal level. Metabolism may be preabsorptive, as with peptides, or during absorption, particularly as a result of the activity of the intracellular enzyme CYP3A4. Absorption may be transcellular (membrane diffusion, carrier-mediated, endocytosis) or paracellular, while p-glycoprotein activity in the apical cell membrane may limit bioavailability by expelling drugs from the mucosal cells. Knowledge of the absorption mechanism is important in determining formulation strategies. The different in vitro techniques used to study absorption have advantages and disadvantages. Ussing chambers can be useful to measure bidirectional transport, but most studies use simple salt media, and full tissue viability is doubtful. Caco-2 cell monolayers are human cells, but the system is static, and gives very low rates of transport, and exagerated enhancement of the paracellular route compared with small intestine. The rat everted gut sac incubated in tissue culture medium maintains tissue viability and gives reliable data, although it is a closed system. In situ perfusion gives no information on events at the cellular level, and absorption may be reduced by anaesthesia and surgical manipulation. In vivo perfusion in man, with multichannel tubes, gives valuable data, but is not practical for screening. Pharmacokinetic modelling can also give useful data such as the existence of different absorption sites. Permeability values from the literature show that for small hydrophilic molecules, which pass by the paracellular route, the improved everted sac gives values close to those for humans, while values with Caco-2 cells are orders of magnitude lower.
The structure of the Bartlett Trough (1932)

The Bartlett Trough is one of the major structural and physiographic features of the Caribbean region. It extends in a flat arc, convex toward the north,from the Gulf of Honduras eastward as far as Gonaive Gulf between the two western peninsulas of Haiti, a distance of over 1,000 miles. The width, between Cuba and Jamaica, is nearly 100 miles, and the deepest sounding, according to recent reports, is about 4,000 fathoms, or 31,000 feet below the higher peaks of the Sierra Maestra in Cuba and the Blue Mountains in Jamaica.
Ipilimumab: a promising immunotherapy for melanoma. (2010)

Antibody-based targeting of the immune suppressor molecule cytotoxic T-lymphocyte antigen 4 (CTLA-4) with ipilimumab has been studied in metastatic melanoma in a number of clinical trials, including a recent phase III trial. This marks the first randomized clinical trial reporting an overall survival benefit using immune modulation in metastatic melanoma. Along with its therapeutic benefits, ipilimumab presents unique challenges to clinicians; these are related to the monitoring of treatment response and the management of drug-related toxicities. This drug is currently being investigated in various cancers, and its indications are likely to be expanded.
Nuclear Factor-κB Inhibition by Parthenolide Potentiates the Efficacy of Taxol in Non–Small Cell Lung Cancer <i>In vitro</i> and <i>In vivo</i> (2009)

In this study, we have examined the molecular events induced by parthenolide, a sesquiterpene lactone, and explored possible mechanisms of resistance and sensitization of tumor cells to Taxol. We showed that parthenolide could antagonize Taxol-mediated nuclear factor-kappaB (NF-kappaB) nuclear translocation and activation and Bcl-xl up-regulation by selectively targeting I-kappaB kinase activity. In A549 cells, inhibition of nuclear factor-kappaB by parthenolide resulted in activation of the mitochondrial death pathway to promote cytochrome c release and caspase 3 and 9 activation. In contrast, Taxol alone induced apoptosis via a pathway independent of mitochondria cytochrome c cascade. In addition, depletion of Bcl-xl rescued the apoptotic response to Taxol. Moreover, treatment with parthenolide increased the efficacy of the Taxol-induced inhibition of A549 tumor xenografts in mice. This study elucidated the cellular responses induced by parthenolide that decrease the threshold of mitochondria-dependent apoptosis in the treatment of non-small cell lung cancer cells.
Tests of Cryogenic Fabry–Perot Cavity with Mirrors on Different Substrates (2019)

Experiments were performed with Fabry–Perot optical resonators in vacuum at low temperatures. Mirrors were applied on substrates of various optical materials. An infrared laser with a wavelength of 1.064 microns was used. The pump power at the maximum could reach 450 mW. The evolution of the optical properties of the FP cavity was traced in the temperature range 300–10 K. The main parameters measured were the integral characteristics of the FP resonances–sharpness (finesse) and contrast of interference. Three types of substrates were tested: a sitall, an optical glass with ultra low thermal expansion (ULE); sapphire; and calcium fluoride. During cooling, the degradation of the integral characteristics of the FP cavity was observed for the sitall mirrors due to the loss of the properties of ULE, and for sapphire mirrors due to the birefringence effect. The satisfactory constancy of the integral characteristics of the FP resonator on calcium fluoride was demonstrated in the entire temperature range studied.
Stretchable, Weavable Coiled Carbon Nanotube/MnO2/Polymer Fiber Solid-State Supercapacitors (2015)

Fiber and yarn supercapacitors that are elastomerically deformable without performance loss are sought for such applications as power sources for wearable electronics, micro-devices, and implantable medical devices. Previously reported yarn and fiber supercapacitors are expensive to fabricate, difficult to upscale, or non-stretchable, which limits possible use. The elastomeric electrodes of the present solid-state supercapacitors are made by using giant inserted twist to coil a nylon sewing thread that is helically wrapped with a carbon nanotube sheet, and then electrochemically depositing pseudocapacitive MnO2 nanofibers. These solid-state supercapacitors decrease capacitance by less than 15% when reversibly stretched by 150% in the fiber direction, and largely retain capacitance while being cyclically stretched during charge and discharge. The maximum linear and areal capacitances (based on active materials) and areal energy storage and power densities (based on overall supercapacitor dimensions) are high (5.4 mF/cm, 40.9 mF/cm(2), 2.6 μWh/cm(2) and 66.9 μW/cm(2), respectively), despite the engineered superelasticity of the fiber supercapacitor. Retention of supercapacitor performance during large strain (50%) elastic deformation is demonstrated for supercapacitors incorporated into the wristband of a glove.
Low Complexity Block Processing Algorithms for Adaptive Channel Estimation in OFDM Systems (2010)

For pilot-aided channel estimation in orthogonal frequency-division multiplexing (OFDM) systems, adaptive algorithms enable tracking of a time-varying channel. Using several subcarriers for the update step in the adaptive algorithm, i.e., performing block processing, improves the robustness and convergence speed of the adaptation. To decrease the complexity of these algorithms, simplified versions are deduced as well as versions with real-valued filters. In the latter case the number of required arithmetic operations can be reduced significantly not only in the adaptive algorithm but also in the filtering process itself, which represents a dominating part regarding the complexity due to the huge amount of subcarriers of practical OFDM transmission schemes. Simulation results show that gains w.r.t. the convergence behavior can be achieved by real-valued filters compared to complex-valued filters - even in scenarios where real-valued filters are theoretically suboptimum.
The Pseudomonas aeruginosa generalized transducing phage φPA3 is a new member of the φKZ-like group of ‘jumbo’ phages, and infects model laboratory strains and clinical isolates from cystic fibrosis patients (2010)

Pseudomonas aeruginosa is an important pathogen in cystic fibrosis patients, and a model organism for the study of nosocomially acquired infections, biofilms and intrinsic multidrug resistance. In this study we characterize ϕPA3, a new generalized transducing bacteriophage for P. aeruginosa. ϕPA3 transduced chromosomal mutations between PAO1 strains, and infected multiple P. aeruginosa clinical isolates as well as the P. aeruginosa model laboratory strains PAK and PA14. Electron microscopy imaging was used to classify ϕPA3 in the order Caudovirales and the family Myoviridae. The genome of ϕPA3 was sequenced and found to contain 309,208 bp, the second-largest bacteriophage currently deposited in GenBank. The genome contains 378 ORFs and five tRNAs. Many ORF products in the ϕPA3 genome are similar to proteins encoded by P. aeruginosa phage ϕKZ and Pseudomonas chlororaphis phage 201ϕ2-1, and so ϕPA3 was classified genetically as a member of the ϕKZ-like group of phages. This is the first report of a member of this group of phages acting as a generalized transducer. Given its wide host range, high transduction efficiency and large genome size, the 'jumbo' phage ϕPA3 could be a powerful tool in functional genomic analysis of diverse P. aeruginosa strains of fundamental and clinical importance.
The Central Role of Gastrointestinal-Specific Anxiety in Irritable Bowel Syndrome: Further Validation of the Visceral Sensitivity Index (2007)

Overall, the VSI demonstrated excellent psychometric properties providing further support for its use in mechanistic studies of the role of anxiety in irritable bowel syndrome presentation.
Psychometric validation of the SF-36 Health Survey in light chain amyloidosis: results from community-based and clinic-based samples (2017)

This study provided clear and consistent evidence of the psychometric properties of the SF-36 in both community-based and clinic-based samples of patients with AL amyloidosis.
The “Fluad Case” in Italy: Could it have been dealt differently? (2016)

During the influenza vaccination campaign 2014-2015, the reporting of 3 deaths within 48 hours of vaccination with Fluad brought the Italian Medicines Agency (AIFA) to pronounce the withdrawal of 2 batches of vaccine, based on the precautionary principle. Investigations by the Italian National Institute of Health, and by the Pharmacovigilance Risk Assessment Committee (PRAC), the committee at the European Medicines Agency (EMA) responsible for monitoring and assessing the safety profiles of human drugs, concluded that there was a lack of causality between the reported deaths and the vaccines administered. However, the media impact of the decision taken by AIFA, resulted in a lower influenza vaccination coverage compared with the previous years. The aim of our study was to identify possible critical points that may have led to a non-perfect management of the event. A review of the regulatory framework in place was performed, with a particular focus on the Guidelines on Good Pharmacovigilance Practices developed by the EMA to facilitate the signal management process. The management of reports involves the following steps: signal detection, its validation and confirmation, analysis and prioritization, assessment, recommendations for action and the exchange of information. In our opinion, both the signal detection phase and the phase of validation have been critical: the withdrawal of vaccine batches is possible even in case of a single suspected serious adverse reaction. However, aspects such as the biological plausibility, the presence of potential alternative causes and previous awareness should also be considered. Furthermore, the number of reported deaths was consistent with the expected background mortality rate in the vaccinated cohort. The disproportionate media coverage given to the AIFA decision resulted in a reduced vaccine confidence in the general population and in a decreased immunization coverage. Improving the communication on vaccine safety issues is crucial at this stage to restore a climate of trust in this powerful tool for primary prevention.
Herbicidal Activity and Structure, Effect of Variations in Acyl Moiety on Herbicidal Activity of N-Substituted Alpha-Chloroacetamides (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHerbicidal Activity and Structure, Effect of Variations in Acyl Moiety on Herbicidal Activity of N-Substituted Alpha-ChloroacetamidesP. C. Hamm and A. J. SpezialeCite this: J. Agric. Food Chem. 1957, 5, 1, 30–32Publication Date (Print):January 1, 1957Publication History Published online1 May 2002Published inissue 1 January 1957https://pubs.acs.org/doi/10.1021/jf60071a001https://doi.org/10.1021/jf60071a001research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An SiC-MOSFET-Based Nine-Switch Single-Stage Three-Phase AC–DC Isolated Converter (2017)

Three-phase power factor correction rectifiers followed by a dc-dc isolated converter are widely used for conversion of three-phase ac to isolated dc output used for high-power telecommunication loads. In this paper, a reduced device count nine-switch converter topology, which integrates the two stages of a conventional three-phase ac- dc power supply with an isolated dc output voltage for telecom applications is proposed. A novel modulation scheme using three separate 120° phase-shifted high-frequency carriers for the three legs of the proposed converter is developed to drive the switches. It is shown that such modulation scheme leads to interleaved operation of the three dc-dc resonant converters integrated within the proposed topology resulting in low output dc voltage ripple. Justification is provided for the choice of the SiC MOSFET as the enabling technology for the converter. The proposed system with the modulation scheme is validated with a 1.5-kW laboratory prototype, which meets the Energy Star 80PLUS platinum efficiency standard for all loads.
Nonpalpable breast lesions: accuracy of prebiopsy mammographic diagnosis. (1987)

Mammograms of 220 patients who underwent spot localization for removal of nonpalpable breast lesions were reviewed for accuracy of interpretation. Results of subsequent biopsy indicated malignancy in 77 cases. The interpretations of mammograms obtained before biopsy were incorrect in 71 cases (27 false-negative and 44 false-positive studies). Among the false-negative cases, 70% of the abnormalities were determined histologically to be noninfiltrative cancers. An aggressive screening program with preoperative localization and biopsy is needed in questionable cases, since mammographic signs of early or nonpalpable malignancy are often subtle and nonspecific.
Controlling the metal-to-insulator relaxation of the metastable hidden quantum state in 1T-TaS <sub>2</sub> (2015)

Controllable switching between metastable macroscopic quantum states under nonequilibrium conditions induced either by light or with an external electric field is rapidly becoming of great fundamental interest. We investigate the relaxation properties of a "hidden" (H) charge density wave (CDW) state in thin single crystals of the layered dichalcogenide 1T-TaS2, which can be reached by either a single 35-fs optical laser pulse or an ~30-ps electrical pulse. From measurements of the temperature dependence of the resistivity under different excitation conditions, we find that the metallic H state relaxes to the insulating Mott ground state through a sequence of intermediate metastable states via discrete jumps over a "Devil's staircase." In between the discrete steps, an underlying glassy relaxation process is observed, which arises because of reciprocal-space commensurability frustration between the CDW and the underlying lattice. We show that the metastable state relaxation rate may be externally stabilized by substrate strain, thus opening the way to the design of nonvolatile ultrafast high-temperature memory devices based on switching between CDW states with large intrinsic differences in electrical resistance.
T cell-stimulatory Fragments of Foot-and-mouth Disease Virus Released by Mild Treatment With Cathepsin D (1994)

Cathepsin D and cathepsin B are endosomal/lysosomal proteases that are thought to play a role during in vivo antigen processing, releasing fragments for binding to major histocompatibility complex class II products and subsequent presentation to T cells. Here we treated purified foot-and-mouth disease virus (FMDV) strain A10Holland with both enzymes. Cathepsin D, but not cathepsin B, was shown to release fragments from reduced or non-reduced FMDV under mild conditions in vitro. Twenty-eight predominant cathepsin D-released fragments were purified by HPLC and identified by amino acid composition analysis and sequencing. The unseparated set of fragments produced (the digest) was able to stimulate T cells from eight vaccinated cattle. With respect to the response to intact virus the extent of the response to the digest differed between animals: four animals could be classified as good responders, three as intermediate responders and one as a low responder. Subsequently, we investigated the proliferative T cell response to a large set of synthetic peptides in detail for two animals, one belonging to the group of good responders, the other being the low responder. The peptides covered all 28 cathepsin D-released fragments analysed and also several sequences not recovered from the digest. In this way seven T cell sites could be identified, five of which coincided with cathepsin D-released fragments. The other two T cell sites were VP2[54-72], being a homologue of a T cell site identified for FMDV strain O1K and the N terminus of VP4. Whether the most dominantly recognized T cell site was recovered from the digest or not was shown to be related to the good or low response to the digest. These findings suggest a role for cathepsin D in the release of some but not all T cell-stimulatory fragments from FMDV.
Lactoferrin and Immunoglobulin Contents in Camel's Milk (Camelus bactrianus, Camelus dromedarius, and Hybrids) from Kazakhstan (2007)

Lactoferrin (Lf) and IgG were estimated in camel's milk from Kazakhstan, where 2 species of camels (Camelus bactrianus, Camelus dromedarius) and their hybrids cohabit. The concentrations of Lf and IgG were determined according to 3 variation factors: region (n = 4), season (n = 4), and species (n = 5; sample 4 was mixed milk and sample 5 was of unknown origin). The mean values in raw camel's milk were 0.229 +/- 0.135 mg/mL for Lf concentration and 0.718 +/- 0.330 mg/mL for IgG concentration. The seasonal effect was the only significant variation factor observed, with the highest values in the spring for Lf and in the winter for IgG. The Lf concentration varied in 1-wk postpartum milk from 1.422 to 0.586 mg/mL. The range in IgG concentration was wide and decreased from 132 to 4.75 mg/mL throughout the 7 d postpartum, with an important drop after parturition. In fermented milk, the lactoproteins are generally hydrolyzed. For milk samples from undefined species, discriminant analyses did not allow the origin of the species to be determined. A slight correlation between Lf and IgG concentrations was observed in raw milk. The values were slightly higher than those reported in cow's milk, but this difference was insufficient to attribute medicinal virtues to camel's milk.
The Last Indian War: Reassessing the Legacy of American Indian Boarding Schools and the Emergence of Pan-Indian Identity (2016)

The purpose of this research is to reexamine the legacy of federally-maintained boarding schools for American Indian children, particularly in regards to its strong connections to the emergence of Pan-Indian identity during the latter half of the twentieth century. The schools have long retained a reputation of one of the most poignant examples of cultural imperialism in history of the United States. The goal of this paper is not to deny the horrors associated with the American Indian boarding school system, but to emphasize the important and ultimately positive outcome of the development of an American Indian identity that transcends tribal identities. The boarding schools played a more nuanced role in the American Indian history and that they served as a catalyst in the emerging American Indian identity, among others. Using accounts from former students particularly associated with the American Indian Movement of the 1960s and 1970s, it is clear that the schools should be considered a crucial step towards many of the movements associated with Pan-Indianism. The story that emerges through this research is one of great irony-in attempting to crush American Indian culture, the schools actually provided a critical shared experience that resonated with people of varying tribes.