gebhart/patrepeval huggingface dataset:
Purification and Characteristics of Xylanases from Produced Thermophilic Alkalophilic Bacillus K17 (1986)

The culture filtrate of thermophilic alkalophilic Bacillus K17 strain contained two types of xylanases were purified by ammonium sulfate fractionation, DEAD-Sephadex A-50 column chromatography, CM-Sephadex C-50 column chromatography and Sephadex G-100 gel filtration. The purified enzymes were found to be homogeneous by sodium dodecyl sulfate and disc polyacrylamide gel electrophoresis. Xylanase I and II were characterized with respect to molecular weight, optimal temperature and pH, thermal and pH stability, and Michaelis constant. Xylanase II was more active and stable, and showed greater substrate affinity and molecular weight than xylanase I. The activities of xylanases I and II were inhibited by Cu, Ag, Hg and Fe. Xylanase I hydrolyzed xylan to yield xylobiose and higher amount of xylooligosaccharides, but xylanase II produced xylose other than xylobiose and xylooligosacchrides.
Evaluation of Cladribine treatment in refractory celiac disease type II (2011)

Treatment of RCD II with 2-CdA holds promise, showing excellent clinical and histological response rates, and probably less frequent transition into EATL.
Peptidyl-prolyl cis-trans-isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A. (1990)

The prokaryotic peptidyl-prolyl cis-trans-isomerase called "rotamase", a homolog of the human cyclophilin, has been identified in Escherichia coli. The E. coli rotamase, a product of the gene we suggest be called "rot," has been purified to homogeneity after cloning of the gene by the polymerase chain reaction and its overexpression in E. coli. Based on the chymotrypsin-coupled assay using the tetrapeptide substrate succinyl-Ala-Ala-Pro-Phe-p-nitroanilide, the purified protein has rotamase activity identical to human cyclophilin with a catalytic efficiency close to the upper diffusional limit (kcat/Km approximately 1.0 x 10(7) M-1 x S-1 at 10 degrees C). Unlike the human cyclophilins, however, the E. coli rotamase is not significantly inhibited by the immunosuppressant drug cyclosporin A. By spheroplast fractionation of cells harboring the expression vector for the complete rot gene, the rotamase is located in the periplasm, where it could function in refolding of secreted proteins.
Efficient code generation for digital signal processors with parallel and pipelined instructions (2002)

Modern digital signal processors are capable of performing multiple pipelined instructions concurrently. However, strict and complicated coding rules, mostly due to the limitation of the processor's internal structures, must be observed to achieve the full performance. These include the proper selection of operand data types, efficient usage of data and address registers, and novel instruction scheduling to support parallel execution without pipeline conflicts. In this paper, a progressive code generation scheme based on a simulated evolution algorithm is devised. In this scheme, the selection of operand data type is embedded in instruction scheduling so that appropriate choices can be made to support parallel instruction. Instruction scheduling and register allocation, however, are performed in an interleaving and iterative manner. In each iteration, the generated code quality is evaluated and the inferior part is rescheduled. Tested benchmark programs indicate that our scheme can outperform the TI DSP processor C compiler and generate very efficient assembly codes.
The use of phenothiazine dyes to inactivate bovine viral diarrhea virus in goat colostrum. (2004)

The objectives of this study were to determine the optimal concentration of phenothiazine dye required to inactivate bovine viral diarrhea virus (BVDV) in goat colostrum following 60 min of illumination and determine if immunoglobulin concentration is affected by this technique. In addition, the potential of continuous agitation of colostrum during illumination to affect viral kill was investigated. This experiment was designed to more closely approximate on-farm use than a previous pilot study performed by the same investigators. Bovine viral diarrhea virus was used as a model for caprine arthritis-encephalitis virus. Goat colostrum containing BVDV was illuminated for 60 min following the addition of either methylene blue (MB) or methylene violet (MV). Four different concentrations of each dye were evaluated. Illumination was performed in a small, portable chest-type freezer equipped on the inside with white fluorescent lights. Some samples were continuously rocked during illumination, while others remained stationary. Virus levels were determined before and after illumination. Immunoglobulin concentrations were determined for time 0 and 60 min. One microM MB reduced virus to undetectable levels following 60 min of illumination. A concentration of 20 microM MV was required to reduce virus levels to zero. Agitation of colostrum samples had no effect with either MB or MV on whether virus levels were reduced. High concentrations of MB and MV had no important effect on immunoglobulin concentrations.
[Prostatic specific antigen in practice in 1997]. (1998)

PSA (Prostate Specific Antigen) has modified the management of prostatic disease. Changes of PSA levels can be observed in many clinical circumstances other than cancer (endoscopic procedures, prostatitis, medications, etc.). Various methods have been proposed to increase the specificity of PSA in prostatic cancer, particularly when the PSA level is between 4 and 10 ng/ml: age-related PSA, PSA density, PSA velocity, freePSA. These methods allow more refined indications for transrectal biopsies of the prostate which provide the histological evidence essential for the diagnosis of cancer.
From a data description point of view (1973)

article From a data description point of view Share on Author: Diane C. Pirog Smith University of Utah University of UtahView Profile Authors Info & Claims ACM SIGIR ForumVolume 9Issue 3Winter 1974 pp 118–130https://doi.org/10.1145/951761.951773Online:04 November 1973Publication History 1citation139DownloadsMetricsTotal Citations1Total Downloads139Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
DOPPLER Only Navigation Using the TIMATION II Satellite (1973)

The TIMATION (TIME NAVIGATION) satellite navigation system has been proposed for the Department of Defense Navigation Satellite System (DNSS). TIMATION has the capability of providing worldwide instantaneous and continuous three-dimensional position fixes and high-accuracy time transfer via satellite. The TIMATION project is conducted by the Naval Research Laboratory under the sponsorship of the Navy Space Project Office (PME 106) and the Naval Air Systems Command. Two passive-measurement techniques are employed by the TIMATION system. The primary measurement technique uses passive ranging, which is accomplished by measuring the time difference between the navigator's clock and the satellite clock. With the second technique, the satellite transmitter frequency's doppler shift is measured; this is accomplished by measuring the frequency difference between the navigator's frequency source and the satellite frequency standard. A position fix may then be calculated by use of (1) range measurements only, (2) simultaneous range-doppler measurements, or (3) doppler measurements with time synchronization derived from ranging. This report presents an analysis of the navigation and frequency difference results using doppler measurements from the TIMATION II satellite.
Glucocorticoid Repression of AP-1 Is Not Mediated by Competition for Nuclear Coactivators (2001)

Interleukin-6 (IL-6) is a pleiotropic cytokine that is involved in many autoimmune and inflammatory diseases. Transcriptional control of IL-6 gene expression is exerted by various compounds, among which glucocorticoids are the most potent antiinflammatory and immunosuppressive agents currently in use. Glucocorticoids exert their transrepressive actions by negatively interfering with transcription factors, such as nuclear factor-kappaB (NF-kappaB) and AP-1. Both factors make use of the coactivator cAMP response element-binding protein (CREB)-binding protein (CBP) to enhance their transcriptional activities, which led to the hypothesis that a mutual antagonism between p65 or c-Jun and activated glucocorticoid receptor (GR) results from a limited amount of CBP. Recently, we showed that glucocorticoid repression of NF-kappaB-driven gene expression occurs irrespective of the amount of coactivator levels in the cell. In the current study, we extend this observation and demonstrate that also AP-1-targeted gene repression by glucocorticoids is refractory to increased amounts of nuclear coactivators. From results with Gal4 chimeric proteins we conclude that glucocorticoid repression occurs by a promoter-independent mechanism involving a nuclear interplay between activated GR and AP-1, independently of CBP levels in the cell.
INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Progeria: A brief review (2013)

Progeria, also known as Hutchinson Gilford Progeria Syndrome, was initially reported by Jonathan Hutch inson in 1886 and further described by Hastings Gilford in 1 904. It is anatypical genetic disorder, usually not inherited, characterised by extreme short stature, low body we ight, early loss of hair, lipodystrophy, scleroderm a, decreased joint mobility, oesteolysis, facial features that r esemble aged person (premature aging) and accelerated cardiovascular disease. In this, the patients are m entally alert and attentive with normal intelligenc e and emotions. It is mostly caused by a de novo point mutation in the lamin A gene that activates a cryptic slice donor site, producing a truncated mutant protein termed “progerin’’. Clin ical manifestations are evident by the first or sec ond year of life and include the physical characteristics usually as sociated with the elderly. In the past, doctors had to base their solely on physical symptoms but today ProgeriaResearch Foundation has establishedProgeria cell and tis sue banks to assist in further research and diagnostic proces s. Treatment usually includes aspirin which helps p revent the atherothrombotic events, stroke and heart attacks b y hindering platelet aggregation. Vitamin and fluor ide supplementation are also routine therapeutic recommendations for Progeria patients.
Structure-based modeling of protein: DNA specificity (2014)

Protein:DNA interactions are essential to a range of processes that maintain and express the information encoded in the genome. Structural modeling is an approach that aims to understand these interactions at the physicochemical level. It has been proposed that structural modeling can lead to deeper understanding of the mechanisms of protein:DNA interactions, and that progress in this field can not only help to rationalize the observed specificities of DNA-binding proteins but also to allow researchers to engineer novel DNA site specificities. In this review we discuss recent developments in the structural description of protein:DNA interactions and specificity, as well as the challenges facing the field in the future.
Experimental study of shoot-through control methods for qZSI-based DC/DC converters (2010)

This paper proposes a novel step-up DC/DC converter with galvanic isolation - the quasi-Z-source inverter (qZSI) based DC/DC converter and discusses three different shoot-through PWM control methods suitable for this topology. The proposed converter is meant for applications where the wide range of voltage gain is demanded, e.g. with renewable energy sources (fuel cells, photovoltaic cells), in telecom, aerospace and some other applications. For the verification of theoretical assumptions the converter prototype was assembled and tested. Experimental waveforms of the converter operated with different shoot-through PWM control methods are compared and discussed. Design considerations for converter and different control signal generators are provided.
Block-Based Neural Networks for Personalized ECG Signal Classification (2007)

This paper presents evolvable block-based neural networks (BbNNs) for personalized ECG heartbeat pattern classification. A BbNN consists of a 2-D array of modular component NNs with flexible structures and internal configurations that can be implemented using reconfigurable digital hardware such as field-programmable gate arrays (FPGAs). Signal flow between the blocks determines the internal configuration of a block as well as the overall structure of the BbNN. Network structure and the weights are optimized using local gradient-based search and evolutionary operators with the rates changing adaptively according to their effectiveness in the previous evolution period. Such adaptive operator rate update scheme ensures higher fitness on average compared to predetermined fixed operator rates. The Hermite transform coefficients and the time interval between two neighboring R-peaks of ECG signals are used as inputs to the BbNN. A BbNN optimized with the proposed evolutionary algorithm (EA) makes a personalized heartbeat pattern classifier that copes with changing operating environments caused by individual difference and time-varying characteristics of ECG signals. Simulation results using the Massachusetts Institute of Technology/Beth Israel Hospital (MIT-BIH) arrhythmia database demonstrate high average detection accuracies of ventricular ectopic beats (98.1%) and supraventricular ectopic beats (96.6%) patterns for heartbeat monitoring, being a significant improvement over previously reported electrocardiogram (ECG) classification results.
A man-in-the-middle attack on UMTS (2004)

In this paper we present a man-in-the-middle attack on the Universal Mobile Telecommunication Standard (UMTS), one of the newly emerging 3G mobile technologies. The attack allows an intruder to impersonate a valid GSM base station to a UMTS subscriber regardless of the fact that UMTS authentication and key agreement are used. As a result, an intruder can eavesdrop on all mobile-station-initiated traffic.Since the UMTS standard requires mutual authentication between the mobile station and the network, so far UMTS networks were considered to be secure against man-in-the-middle attacks. The network authentication defined in the UMTS standard depends on both the validity of the authentication token and the integrity protection of the subsequent security mode command.We show that both of these mechanisms are necessary in order to prevent a man-in-the middle attack. As a consequence we show that an attacker can mount an impersonation attack since GSM base stations do not support integrity protection. Possible victims to our attack are all mobile stations that support the UTRAN and the GSM air interface simultaneously. In particular, this is the case for most of the equipment used during the transition phase from 2G (GSM) to 3G (UMTS) technology.
Novel Computational Analysis of Left Atrial Anatomy Improves Prediction of Atrial Fibrillation Recurrence after Ablation (2017)

The left atrium (LA) can change in size and shape due to atrial fibrillation (AF)-induced remodeling. These alterations can be linked to poorer outcomes of AF ablation. In this study, we propose a novel comprehensive computational analysis of LA anatomy to identify what features of LA shape can optimally predict post-ablation AF recurrence. To this end, we construct smooth 3D geometrical models from the segmentation of the LA blood pool captured in pre-procedural MR images. We first apply this methodology to characterize the LA anatomy of 144 AF patients and build a statistical shape model that includes the most salient variations in shape across this cohort. We then perform a discriminant analysis to optimally distinguish between recurrent and non-recurrent patients. From this analysis, we propose a new shape metric called vertical asymmetry, which measures the imbalance of size along the anterior to posterior direction between the superior and inferior left atrial hemispheres. Vertical asymmetry was found, in combination with LA sphericity, to be the best predictor of post-ablation recurrence at both 12 and 24 months (area under the ROC curve: 0.71 and 0.68, respectively) outperforming other shape markers and any of their combinations. We also found that model-derived shape metrics, such as the anterior-posterior radius, were better predictors than equivalent metrics taken directly from MRI or echocardiography, suggesting that the proposed approach leads to a reduction of the impact of data artifacts and noise. This novel methodology contributes to an improved characterization of LA organ remodeling and the reported findings have the potential to improve patient selection and risk stratification for catheter ablations in AF.
A Rapid and Automated Sample‐to‐Result HIV Load Test for Near‐Patient Application (2010)

Results suggest that the Liat HIV Quant Assay has performance equivalent to that of commercial HIV load assays and significantly reduces assay time, simplifies test operation, and provides biocontainment to allow operation in nonlaboratory settings.
Beneficial Use Of C&D Recovered Screen Material In Residential Applications: A Case Study (2010)

Florida has established guidelines to encourage recycling and use of recycled materials in a manner protecting public health and the environment. Recovered screened material (RSM) generated at a construction and demolition (C&D) debris recovery facility is a recycled material with reuse potential. In order to reuse RSM, it must be shown that the material poses no significant threat to public health or the environment. The Sun Recycling facilities in Broward and Palm Beach counties are C&D facilities, generating RSM (i.e., soil with wood, concrete, other C&D particles) through mechanical separation using screens. The process generates RSM meeting state requirements for industrial, commercial, and residential use. RSM was used on residential lots in Miramar to elevate low areas (excluding building pads). In accord with Broward County Environmental Protection Department (EPD) and Palm Beach County Department of Health (DOH) permits, Sun facilities perform regular testing of RSM. RSM tests showed arsenic (As) concentrations below state criteria. Quarterly testing did not detect volatile organic compounds (VOCs), semivolatile organic compounds (SVOCs), or pesticides. RSM was delivered to homesites and mixed with existing site soil. To address concerns raised by some residents, Miramar hired a consultant to collect samples for arsenic and total recoverable petroleum hydrocarbons (TRPH), resulting in reports of some As levels above residential criteria. Further sampling/analysis of RSM and local soils in the neighborhood were performed by Broward EPD and Sun. Results of As and speciated TRPH Clark et al.: Beneficial Use Of C&D Recovered Screen Material... Produced by The Berkeley Electronic Press, 2006 356 Contaminated SoilsSite Assessment analysis performed by the Miramar, Broward EPD, and Sun will be discussed. A consensus conclusion of acceptable conditions was reached by all parties.
A simplified procedure for decoding the (23,12) and (24,12) Golay codes (1989)

A simplified procedure is developed to decode the three possible erors in a (23,12) Golay codeword. A computer simulation shows that this algorithm is modular, regular and naturally suitable for both Very Large Scale Integration (VLSI) and software implementation. An extension of this new decoding procedure is used also to decode the 1/2-rate (24,12) Golay code, thereby correcting three and detecting four errors.
Requirement and role of arachidonic acid in the differentiation of pre-adipose cells (1989)

The terminal adipose differentiation of Ob1771 cells, characterized by glycerol-3-phosphate dehydrogenase activity and triacylglycerol accumulation, was studied in serum-free hormone-supplemented medium containing growth hormone, tri-iodothyronine, insulin, transferrin and fetuin. Arachidonic acid was able to substitute for a crude adipogenic fraction isolated from fetal bovine serum but not for growth hormone or tri-iodothyronine. Arachidonic acid was also able to increase in a rapid and dramatic manner cyclic AMP production; moreover it was able to amplify the adipose conversion promoted by other agents elevating cyclic AMP concentrations and to induce inositol phospholipid breakdown. Both phorbol 12-myristate 13-acetate, a protein kinase C activator and ionomycin, a Ca2+-mobilizing agent, showed potent synergy with agents elevating cyclic AMP concentrations for the promotion of adipose conversion, whereas 8-bromo cyclic GMP and 4 alpha-phorbol 12,13-dibutyrate were ineffective. The triggering of both the cyclic AMP and inositol phospholipid pathways was accompanied by a single round of cell division, and within a few days all the cells became differentiated. Similar results were obtained, after exposure to arachidonic acid, with preadipose 3T3-F442A cells and with rat adipose precursor cells in primary culture. The availability of arachidonic acid from intracellular stores and/or of exogenous origin should play a major role for the onset of critical mitoses leading to terminal differentiation in pre-adipose cells.
Local-mode effects on the rotational structure of the first stretching overtone band system of stibine, SbH3 (1991)

A high-resolution Fourier-transform infrared spectrum, resolution about 0.006 cm−1, of the first stretching overtone band system of stibine has been measured and rotationally analyzed in detail up to J′=22 for both 121SbH3 and 123SbH3 isotopic species. The rotational levels of the A1 and E vibrational states have been analyzed simultaneously by including vibration–rotation coupling terms in the Hamiltonian for the two isotopic species. The A1/E vibrational energy-level separation has been found to be 0.0727(8) cm−1 for 121SbH3 and 0.0763(8) cm−1 for 123SbH3 with the A1 state being higher in energy in both cases. Fits including 1445 transitions with the standard deviation of 0.0024 cm−1 for 121SbH3 and 1322 transitions with the standard deviation of 0.0022 cm−1 for 123SbH3 have been obtained by optimizing altogether 33 upper-state parameters in both cases. A simple local-mode model is shown to account very well for the vibrational dependence of the rotational constants and the coefficients of vibrationally off-diagonal H22 operators.
The Specific Binding of l-Tryptophan to Serum Albumin (1958)

Acetylation of Guanidinated Albumin-Guanidinated albumin preparations 5AII and 5CII were acetylated under the conditions specified in Table I.The groups acetylatrd wcrc determined by paper chromatography.
Intersubband transitions at 1.3 and 1.55 /spl mu/m in a novel coupled InGaAs-AlAsSb double-quantum-well structure (1999)

We report the first observation of intersubband absorption at 1.3 μm in a coupled InGaAs-AlAsSb double-quantum-well structure lattice matched to InP substrate. The novel structure exhibits intersubband transitions concurrently at 1.3 and 1.55 μm due to the strong coupling of the intersubband states of the adjacent wells. A transient analysis of optical response in the multilevel conduction subband states for the designed structure indicates ultrafast optical switching behavior with a subpicosecond response.