gebhart/patrepeval huggingface dataset:
The Effects of Intra-Amygdala Injection of Nicotine and Harmaline on Anxiey- Related Behavior in Adult Male Rat (2012)

<p><span style="font-family: TimesNewRomanPSMT; font-size: x-small;"><span style="font-family: TimesNewRomanPSMT; font-size: x-small;"><span style="font-family: TimesNewRomanPSMT; font-size: x-small;"><span style="font-family: TimesNewRomanPSMT; font-size: x-small;"><span style="line-height: 115%; font-family: 'Times New Roman','serif'; font-size: 9.5pt; mso-fareast-font-family: Calibri; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: FA;">B-carboline alkaloids such as harmaline and nicotine are naturally present in the human food chain. Plants which contain B-caroline have anxiety and hallucinogenic effects. In this study the change in like – anxiety behaviors was investigated after intra- amygdala injections of nicotine and harmaline and intra action of them in male rat. Different doses of Harmaline, Nicotine and its compounds were applied for 30 minutes, before test of anxiety injection to (CeA) amygdale. Then like anxiety behavior include open arm time and Locomotor activity, spent open arm time, entriar open arm in maze were examined for 5 minute . Bilateral injection of Harmaline and Nicotine was decreased in to (CeA) amygdale one-by- one open arm times in control group. Injections of effective does of Nicotine could increase anxiety effects of Harmaline. Furthermore, Injection of ineffective doses of drugs has increased anxiety. The results show that Harmaline and Nicotine have anxiety effects. Also muscarinic and Nicotine receptor have important role in Like- anxiety behaviors. Acetylcholine in CeA amygdale thorough Nicotine receptors caused anxiety behaviors. Joined injection increased them effective.</span></span></span></span></span></p>
Desktop computers: in perspective (1993)

PC systems PC applications PC system performance and configuration Microcomputer hardware fundamentals Microcomputer operating systems Data formats and compatibility Application software overview Text processing Database management Spreadsheets Integrated software Asynchronous communications software Graphics Languages Management software Engineering/scientific software Utilities and enhancement software Educational software Software selection criteria PC system units PC peripherals and selection Introduction to networking Historical perspective Current limitations in personal computing Future trends Important managerial considerations Final comments.
Appeals in Custody Cases (1983)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
β-Cyclodextrin coated lithium vanadium phosphate as novel cathode material for lithium ion batteries (2016)

As a new carbon source, β-cyclodextrin was used to synthesize a Li<sub>3</sub>V<sub>2</sub>(PO<sub>4</sub>)<sub>3</sub>/C cathode material for LIB <italic>via</italic> a rheological phase method. The sample showed high capacity, good rate performance and cycle stability, and low resistance.
A Cluster Analysis of Bacterial Vaginosis–associated Microflora and Pelvic Inflammatory Disease (2005)

Controversy surrounds the association between bacterial vaginosis (BV) and pelvic inflammatory disease (PID). Women (N = 1,140) were ascertained at five US centers, enrolled (1999-2001), and followed up for a median of 3 years. Serial vaginal swabs were obtained for Gram's stain and cultures. PID was defined as 1) histologic endometritis or 2) pelvic pain and tenderness plus oral temperature >38.8 degrees C, leukorrhea or mucopus, erythrocyte sedimentation rate >15 mm/hour, white blood cell count >10,000, or gonococcal/chlamydial lower genital infection. Exploratory factor analysis identified two discrete clusters of genital microorganisms. The first correlated with BV by Gram's stain and consisted of the absence of hydrogen peroxide-producing lactobacillus, Gardnerella vaginalis, Mycoplasma hominis, anaerobic gram-negative rods, and, to a lesser degree, Ureaplasma urealyticum. The second, unrelated to BV by Gram's stain, consisted of Enterococcus species and Escherichia coli. Being in the highest tertile in terms of growth of BV-associated microorganisms increased PID risk (adjusted rate ratio = 2.03, 95% confidence interval: 1.16, 3.53). Carriage of non-BV-associated microorganisms did not increase PID risk. Women with heavy growth of BV-associated microorganisms and a new sexual partner appeared to be at particularly high risk (adjusted rate ratio = 8.77, 95% confidence interval: 1.11, 69.2). When identified by microbial culture, a combination of BV-related microorganisms significantly elevated the risk of acquiring PID.
Algebraic methods for deterministic blind beamforming (1998)

Deterministic blind beamforming algorithms try to separate superpositions of source signals impinging on a phased antenna array by using the deterministic properties of the signals or the channels such as their constant modulus or directions-of-arrival. Progress in this area has been abundant over the past ten years and has resulted in several powerful algorithms. Unlike optimal or adaptive methods, the algebraic methods discussed in this review act on a fixed block of data and give closed-form expressions for beamformers by focusing on algebraic structures. This typically leads to subspace estimation and generalized eigenvalue problems. After introducing a simple and widely used multipath channel model, the paper provides an anthology of properties that are available, as well as generic algorithms that exploit them.
Holonic robot control for job shop assembly by dynamic simulation (2008)

The paper describes a holonic control solution for fault-tolerant job shop assembly with networked robots, based on the dynamic simulation of material processing and transportation. The designed holarchy considers the PROSA reference architecture, and was implemented by help of an object oriented step scheduler (off-line production planning, failure- and recovery management, and online production tracking) and OPC-based real-time PLC software integration (execution of order holons at batch level). Experimental results are reported as well as considerations about holarchy mapping on the computing architecture and future developments.
Disruption of kerogen-mineral interactions in Rundle Ramsay Crossing oil shale (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDisruption of kerogen-mineral interactions in Rundle Ramsay Crossing oil shaleM. Siskin, G. Brons, and J. F. Payack, Jr.Cite this: Energy Fuels 1989, 3, 1, 108–109Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ef00013a019https://doi.org/10.1021/ef00013a019research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Calmodulin and HIV Type 1: Interactions with Gag and Gag Products (2000)

The level of calmodulin increases in cells expressing HIV-1 envelope glycoprotein. Although a calmodulin increase is bound to alter many cellular metabolic and signaling pathways, the benefits to the virus of these alterations must be indirect. However, the possibility exists that increased cellular calmodulin benefits the virus by directly associating with nonenvelope viral proteins. We have, therefore, investigated whether calmodulin can interact with HIV structural proteins Gag, p17, and p24. Calmodulin binds Gag and p17 but not p24 in (125)I-labeled calmodulin overlays of SDS-polyacrylamide gels. Removal of calcium by addition of EGTA eliminates this binding. A computer algorithm for predicting helical regions that should bind calmodulin predicts that there are two calmodulin-binding regions near the N terminus of p17. Intrinsic tryptophan fluorimetry shows that two peptides, each of which includes one of the predicted regions, bind calmodulin: p17(11-25) binds calmodulin with a 2-to-1 stoichiometry and dissociation constant of approximately 10(-9) M(2), and p17(31-46) also binds calmodulin with a dissociation constant of about 10(-9) M. These binding sites are nearly contiguous, forming an extended calmodulin-binding domain p17(11-46). In H-9 cells, Gag and calmodulin colocalize within the resolution of confocal light microscopy.
Architecture blueprints---the “4+1” view model of software architecture (1995)

No abstract available.
Silicon-Embedded Receiving Coil for High-Efficiency Wireless Power Transfer to Implantable Biomedical ICs (2012)

In this letter, a silicon-embedded receiving coil is designed and fabricated for high-efficiency wireless power transfer to implantable biomedical ICs. The 4.5 mm × 4.5 mm embedded receiving coil achieved a large inductance of 4 μH and a high peak quality factor of 20 at 2.8 MHz. Measurement results of an inductive power link using the embedded receiving coil and a conventional printed-circuit-board transmitting coil (2 cm × 2 cm) demonstrated peak voltage gains of 0.84 and 0.24 and peak efficiency values of 30% and 4.3% for separation distances of 5 and 12 mm, respectively. This is the best reported wireless power transmission efficiency for separation distance similar to the implant chip size.
Shakti-T (2017)

With increased usage of compute cores for sensitive applications, including e-commerce, there is a need to provide additional hardware support for securing information from memory based attacks. This work presents a unified hardware framework for handling spatial and temporal memory attacks. The paper integrates the proposed hardware framework with a RISC-V based micro-architecture with an enhanced application binary interface that enables software layers to use these features to protect sensitive data. We demonstrate the effectiveness of the proposed scheme through practical case studies in addition to taking the design through a VLSI CAD design flow. The proposed processor reduces the metadata storage overhead up to 4 x in comparison with the existing solutions, while incurring an area overhead of just 1914 LUTs and 2197 flip flops on an FPGA, without affecting the critical path delay of the processor.
Stimulation of the Parapyramidal Region of the Neonatal Rat Brain Stem Produces Locomotor-Like Activity Involving Spinal 5-HT<sub>7</sub> and 5-HT<sub>2A</sub> Receptors (2005)

Locomotion can be induced in rodents by direct application 5-hydroxytryptamine (5-HT) onto the spinal cord. Previous studies suggest important roles for 5-HT7 and 5-HT2A receptors in the locomotor effects of 5-HT. Here we show for the first time that activation of a discrete population of 5-HT neurons in the rodent brain stem produces locomotion and that the evoked locomotion requires 5-HT7 and 5-HT2A receptors. Cells localized in the parapyramidal region (PPR) of the mid-medulla produced locomotor-like activity as a result of either electrical or chemical stimulation, and PPR-evoked locomotor-like activity was blocked by antagonists to 5-HT2A and 5-HT7 receptors located on separate populations of neurons concentrated in different rostro-caudal regions. 5-HT7 receptor antagonists blocked locomotor-like activity when applied above the L3 segment; 5-HT2A receptor antagonists blocked locomotor-like activity only when applied below the L2 segment. 5-HT7 receptor antagonists decreased step cycle duration, consistent with an action on neurons involved in the rhythm-generating function of the central pattern generator (CPG) for locomotion. 5-HT2A antagonists reduced the amplitude of ventral root activity with only small effects on step cycle duration, suggesting an action directly on cells involved in the output stage of the pattern generator for locomotion, including motoneurons and premotor cells. Experiments with selective antagonists show that dopaminergic (D1, D2) and noradrenergic (alpha1, alpha2) receptors are not critical for PPR-evoked locomotor-like activity.
Raman scattering of carbon nanotube bundles under axial strain and strain-induced debundling (2007)

We measure resonant Raman scattering of individual carbon nanotube bundles under axial strains of up to 17%. The main effect of this strain is to cause debundling of the nanotubes. The $G$ band Raman spectra of metallic and semiconducting nanotubes respond differently to strain and debundling, giving insight into the nature of the broad metallic ${G}_{\ensuremath{-}}$ band line shape. For metallic nanotubes, the ${G}_{\ensuremath{-}}$ band upshifts and becomes narrower with strain, making it appear more semiconductor-like. Surprisingly, this metal to semiconductor transition is not reversible with strain, indicating that nanotube-nanotube coupling plays a significant role in the observed ${G}_{\ensuremath{-}}$ band of unperturbed metallic nanotubes.
Passive immunization with monoclonal antibodies against herpes simplex virus glycoproteins protects mice against herpetic ocular disease (1987)

The effects of passive immunization with specific monoclonal antibodies against herpes simplex virus glycoproteins gB, gC, gD, and gE on the course of herpetic keratitis, survival and the establishment of latency in an outbred mouse model are described. A total of nine monoclonal antibodies were tested in these experiments. Passive immunization at 24 or 48 hours post-inoculation had little effect on the severity of the initial epithelial infection of the cornea, but blocked dissemination of the virus to the central nervous system and periocular tissues and prevented development of blepharitis, iritis and stromal keratitis. Additional studies are needed to characterize these monoclonal antibodies in greater detail, and to define the mechanism of these protective effects.
Acquisition of Resistance to Carbapenems in Multidrug-Resistant Clinical Strains of <i>Acinetobacter baumannii</i> : Natural Insertional Inactivation of a Gene Encoding a Member of a Novel Family of β-Barrel Outer Membrane Proteins (2005)

The outer membrane proteins responsible for the influx of carbapenem beta-lactam antibiotics in the nonfermentative gram-negative pathogen Acinetobacter baumannii are still poorly characterized. Resistance to both imipenem and meropenem in multidrug-resistant clinical strains of A. baumannii is associated with the loss of a heat-modifiable 29-kDa outer membrane protein, designated CarO. The chromosomal locus containing the carO gene was cloned and characterized from different clinical isolates. Only one carO copy, present in a single transcriptional unit, was found in the A. baumannii genome. The carO gene encodes a polypeptide of 247 amino acid residues with a typical N-terminal signal sequence and a predicted transmembrane beta-barrel topology. Its absence from different carbapenem-resistant clinical isolates of A. baumannii resulted from the disruption of carO by distinct insertion elements. The overall data thus support the notion that CarO participates in the influx of carbapenem antibiotics in A. baumannii. Moreover, database searches identified the presence of carO homologs only in species of the genera Acinetobacter, Moraxella, and Psychrobacter, disclosing the existence of a novel family of outer membrane proteins restricted to the family Moraxellaceae of the class gamma-Proteobacteria.
MOTION DETECTION FROM TIME-VARIED BACKGROUND (2002)

This paper proposes a new background subtraction method for detecting moving objects (foreground) from a time-varied background. While background subtraction has traditionally worked well for stationary backgrounds, for a non-stationary viewing sensor, motion compensation can be applied but is difficult to realize to sufficient pixel accuracy in practice, and the traditional background subtraction algorithm fails. The problem is further compounded when the moving target to be detected/tracked is small, since the pixel error in motion compensating the background will subsume the small target. A Spatial Distribution of Gaussians (SDG) model is proposed to deal with moving object detection under motion compensation that has been approximately carried out. The distribution of each background pixel is temporally and spatially modeled. Based on this statistical model, a pixel in the current frame is classified as belonging to the foreground or background. For this system to perform under lighting and environmental changes over an extended period of time, the background distribution must be updated with each incoming frame. A new background restoration and adaptation algorithm is developed for the time-varied background. Test cases involving the detection of small moving objects within a highly textured background and a pan-tilt tracking system based on a 2D background mosaic are demonstrated successfully.
Effect of compressibility on performance of hydraulic wash columns (2002)

Abstract In a hydraulic wash column the solid crystals are separated from the mother liquor by filtration in the top section of the column. Remaining impurities are removed via countercurrent washing of the crystals in the bottom section. Since compressibility limits the capacity of a wash column, this phenomenon needs to be quantified and modeled rigorously. The compressibility of the bed was determined from the porosity profile and the liquid‐pressure profile inside the wash column. The porosity of the bed decreases from 0.65 to 0.3 during transport of the bed. This is associated with a decrease in local bed permeability by a factor of 10. The compressibility of the bed, therefore, partly explains the large ratio between the average permeability above and below the wash front. Compressibility coefficients make it possible to relate the compressive stress to the porosity and permeability in the top section of the bed. These coefficients are, therefore, incorporated in a model to successfully predict the capacity of a wash column with a compressible bed.
Les oligonucléotides antisens : outils de génétique moléculaire et agents thérapeutiques (1990)

The binding of an oligodeoxynucleotide, so-called anti-sense, to the complementary sequence of a messenger RNA can prevent the synthesis of the encoded protein. This approach constitutes a very efficient and specific means to artificially regulate gene expression. Numerous chemical modifications have been introduced into synthetic oligos in order to provide them with properties that unmodified molecules do not display. For instance, oligos built up with methylphosphonate, phosphorothioate and alpha-anomer units lead to molecules that are resistant to DNases. Acridine-linked oligos exhibit an increased affinity for the target sequence due to the intercalation of the dye into the oligo/RNA duplex. Two different mechanisms account for translation inhibition by antisense oligos. Inhibition of the elongation step results only from the induced cleavage of the target RNA by RNase-H. In contrast, oligos targeted upstream of the AUG initiation codon can block the initiation step through an RNase-H independent mechanism. As a consequence, methylphosphonate- and alpha-oligos, which do not elicit RNase-H activity, targeted to the 5' region, are efficient antisense; but they are inactive if targeted to the coding sequence. Experiments performed with antisense oligos in cell-free extracts supported the notion that the mini-exon sequence, acquired by trans-splicing, was present on every message in trypanosomatids and on some of them in nematodes. Furthermore, an acridine-linked oligo complementary to the mini-exon sequence of Trypanosoma brucei induced a lethal effect on cultured procyclics. Therefore these compounds constitute promising tools in molecular genetics and could open new routes to rationally tailor therapeutic agents.
The p75 Neurotrophin Receptor Promotes Amyloid-β(1-42)-Induced Neuritic Dystrophy<i>In Vitro</i>and<i>In Vivo</i> (2009)

Oligomeric forms of amyloid-beta (Abeta) are thought to play a causal role in Alzheimer's disease (AD), and the p75 neurotrophin receptor (p75(NTR)) has been implicated in Abeta-induced neurodegeneration. To further define the functions of p75(NTR) in AD, we examined the interaction of oligomeric Abeta(1-42) with p75(NTR), and the effects of that interaction on neurite integrity in neuron cultures and in a chronic AD mouse model. Atomic force microscopy was used to ascertain the aggregated state of Abeta, and fluorescence resonance energy transfer analysis revealed that Abeta oligomers interact with the extracellular domain of p75(NTR). In vitro studies of Abeta-induced death in neuron cultures isolated from wild-type and p75(NTR-/-) mice, in which the p75(NTR) extracellular domain is deleted, showed reduced sensitivity of mutant cells to Abeta-induced cell death. Interestingly, Abeta-induced neuritic dystrophy and activation of c-Jun, a known mediator of Abeta-induced deleterious signaling, were completely prevented in p75(NTR-/-) neuron cultures. Thy1-hAPP(Lond/Swe) x p75(NTR-/-) mice exhibited significantly diminished hippocampal neuritic dystrophy and complete reversal of basal forebrain cholinergic neurite degeneration relative to those expressing wild-type p75(NTR). Abeta levels were not affected, suggesting that removal of p75(NTR) extracellular domain reduced the ability of excess Abeta to promote neuritic degeneration. These findings indicate that although p75(NTR) likely does not mediate all Abeta effects, it does play a significant role in enabling Abeta-induced neurodegeneration in vitro and in vivo, establishing p75(NTR) as an important therapeutic target for AD.
Colonisation and transmission of Clostridium difficile in healthy individuals examined by PCR ribotyping and pulsed-field gel electrophoresis (2001)

Healthy adults who had not been exposed to antimicrobial agents for the preceding 4 weeks were examined for intestinal carriage of Clostridium difficile. The 1234 individuals examined were composed of seven groups: three classes of university students, hospital workers at two hospitals, employees of a company and self-defence force personnel at a local station. Overall, 94 (7.6%) individuals were positive for C. difficile by faecal culture but carriage rates among the study groups ranged from 4.2% to 15.3%. Typing by PCR ribotyping and pulsed-field gel electrophoresis demonstrated clusters of carriers colonised by a single type in each of three groups, indicating that cross-transmission of C. difficile can occur in community settings. Follow-up culture was performed on 38 C. difficile-positive individuals and C. difficile was isolated again from 12 (32%) of them 5-7 months after the initial culture; six (50%) of these 12 individuals had a new strain on repeat culture. Two or more family members were C. difficile-positive in five of 22 families examined. C. difficile with an identical type was isolated from persons within a family in only one family. These results suggest that intestinal carriage by healthy adults may play a role as a reservoir for community-acquired C. difficile-associated diarrhoea, but that cross-transmission of C. difficile does not occur frequently among family members at home.