Angiogenesis Inhibitor TNP-470 Suppresses Tumorigenesis In Rat Urinary Bladder (1997)

No AccessJournal of UrologyInvestigative Urology1 Feb 1997Angiogenesis Inhibitor TNP-470 Suppresses Tumorigenesis In Rat Urinary Bladder Yoshinori Tanaka, Hitoshi Kawamata, Kiyohide Fujimoto, and Ryoichi Oyasu Yoshinori TanakaYoshinori Tanaka , Hitoshi KawamataHitoshi Kawamata , Kiyohide FujimotoKiyohide Fujimoto , and Ryoichi OyasuRyoichi Oyasu View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65250-9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The efficacy of the anti-angiogenic factor TNP-470, an analogue of fumagillin, in controlling the development of bladder tumors was investigated. Materials and Methods: The anti-angiogenic activity of TNP-470 was evaluated in vitro by its capacity to suppress the growth and migration of bovine capillary endothelial cells. To investigate its effect in vivo on the development of tumors, we instilled 0.5 micro g. of TNP-470 dissolved in rat urine into heterotopically transplanted rat urinary bladders in which carcinogenesis had been initiated by N-methyl-N-nitrosourea. Results: In vitro, TNP-470 selectivity inhibited the growth and migration of endothelial cells. Instillation of TNP-470 shortly after treatment with carcinogen reduced the tumor incidence significantly (p <0.05) as compared with that in control animals receiving urine only. Conclusions: TNP-470 suppresses the development of bladder tumors when the treatment is started at an early stage of neoplasia. It may be useful in preventing recurrences or new growth of bladder tumors. References 1 : Urothelial tumors of the urinary tract. In: . Philadelphia: W. B. Saunders Compan1992: 1094. chapt. 28. 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Google Scholar Department of Pathology, Northwestern University Medical School, Chicago, Illinois.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byREIHER F, OZER O, PINS M, JOVANOVIC B, EGGENER S and CAMPBELL S (2018) p53 AND MICROVESSEL DENSITY IN PRIMARY RESECTION SPECIMENS OF SUPERFICIAL BLADDER CANCERJournal of Urology, VOL. 167, NO. 3, (1469-1474), Online publication date: 1-Mar-2002.REIHER F, ANOVICH M, HUANG H, SMITH N, BOUCK N and CAMPBELL S (2018) THE ROLE OF HYPOXIA AND p53 IN THE REGULATION OF ANGIOGENESIS IN BLADDER CANCERJournal of Urology, VOL. 165, NO. 6 Part 1, (2075-2081), Online publication date: 1-Jun-2001.Campbell S (2018) ADVANCES IN ANGIOGENESIS RESEARCH: RELEVANCE TO UROLOGICAL ONCOLOGYJournal of Urology, VOL. 158, NO. 5, (1663-1674), Online publication date: 1-Nov-1997. Volume 157Issue 2February 1997Page: 683-688 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Yoshinori Tanaka More articles by this author Hitoshi Kawamata More articles by this author Kiyohide Fujimoto More articles by this author Ryoichi Oyasu More articles by this author Expand All Advertisement PDF downloadLoading ...