gebhart/patrepeval huggingface dataset:
Readmissions in a surgical intensive care unit: patient characteristics and outcome (2003)

Aims: To determine the incidence, patient characteristics, reasons and outcome of readmissions in a surgical ICU.
Patients and Methods: Analysis of 1316 admissions in 1190 patients. Patients were classified as those who never required readmission (NOREAD, n = 1086) and those who had > 1 ICU admission (READ, n =104 patients and 230 admissions) and those readmitted within 48 hours and those after 48 hrs. 
Results: 104 (8.7%) patients required ICU readmission. Of these 17 (1.4% of total and 16.3% of readmitted patients) were readmitted within 48 hrs. Readmission rates were maximum in patients with GI system involvement (n=66, 66.5%) followed by respiratory system involvement (n = 22, 21%). 22%patients were readmitted due to complications involving the same organ system, 58% (n = 60/104) patients were readmitted due to complications involving new organ system and 20% (n = 21/104) were readmitted following operative intervention. The readmission APACHE score was higher than in NOREAD GROUP (15.46+9.61Vs 12.01+8.66). The readmitted patients had a longer ICU stay (5.68+6.75 Vs 3.76+6.61 days) and higher mortality rate (34% Vs 17.4%) than the NOREAD GROUP.
Conclusion: Patients with surgery of GI and RS are at greatest risk of ICU readmission. Respiratory complications are the major reason for ICU readmission due to new complication. Readmitted patients have a longer duration of ICU stay and higher mortality rate than those who are not readmitted. The readmission rate is affected by case-mix of the ICU.
Contribution of uric acid to cancer risk, recurrence, and mortality (2012)

Two risk factors for the development and progression of cancers that are amenable to life style modification are chronic inflammation and the metabolic syndrome. This review proposes two new targets that may mechanistically integrate inflammation and metabolic syndrome, have been largely ignored, and are known to be druggable. Recent evidence has demonstrated that elevated serum uric acid (hyperuricemia) is associated with excess cancer risk, recurrence, and mortality. Although uric acid (UA) can function as a systemic antioxidant, its pro-inflammatory properties have been postulated to play an important role in the pathogenesis of cancer. Furthermore, obesity, Type 2 Diabetes Mellitus (T2DM), and the metabolic syndrome (MetS) are also associated with excess cancer, chronic inflammation, and with hyperuricemia, suggesting that UA may represent an important link between these disorders and the development of cancer. While pharmacological modulation of hyperuricemia could in principal augment anti-cancer therapeutic strategies, some cancer cells express low intracellular levels of the enzyme Xanthine Oxidoreductase (XOR) that are associated with increased cancer aggressiveness and poor clinical outcome. Thus, systemic pharmacological inhibition of XOR may worsen clinical outcome, and specific strategies that target serum uric acid (SUA) without inhibiting tumor cell XOR may create new therapeutic opportunities for cancer associated with hyperuricemia. This review will summarize the evidence that elevated SUA may be a true risk factor for cancer incidence and mortality, and mechanisms by which UA may contribute to cancer pathogenesis will be discussed in the hope that these will identify new opportunities for cancer management.
Superoxide Dismutase Activity Measurement Using Cytochrome<i>c</i>-Modified Electrode (1999)

SOD activity was quantified by the use of a cytochrome c-modified gold electrode. The electrode responded rapidly to superoxide radicals in solution. Steady-state superoxide concentrations were established by control of the calibration conditions. On this basis very low SOD activities were detected (10-200 munits/mL). This method showed good correlation with the standard photometric test and was applied for the determination of SOD activity entrapped into liposomes. Interference by hydrogen peroxide and uric acid was characterized and minimized using long-chain thiols for the first electrode modification step. The complete modification proved to be stable for several days.
Exploration of miRNA families for hypotheses generation (2013)

Technological improvements have resulted in increased discovery of new microRNAs (miRNAs) and refinement and enrichment of existing miRNA families. miRNA families are important because they suggest a common sequence or structure configuration in sets of genes that hint to a shared function. Exploratory tools to enhance investigation of characteristics of miRNA families and the functions of family-specific miRNA genes are lacking. We have developed, miRNAVISA, a user-friendly web-based tool that allows customized interrogation and comparisons of miRNA families for hypotheses generation, and comparison of per-species chromosomal distribution of miRNA genes in different families. This study illustrates hypothesis generation using miRNAVISA in seven species. Our results unveil a subclass of miRNAs that may be regulated by genomic imprinting, and also suggest that some miRNA families may be species-specific, as well as chromosome- and/or strand-specific.
Liver-specific RNA processing of the ubiquitously transcribed rat fibrinogen gamma-chain gene (1992)

Fibrinogen gamma-chains differ in amino acid sequence at the carboxyterminus due to alternative 3′ RNA processing. Previous studies reported differences between humans and rats in the mechanism of gamma- chain RNA processing and that it was a nonregulated event. To test the hypothesis that rat gamma-chain RNA processing involves both alternative splicing and poly(A) site selection and that it is regulated in a tissue-specific manner, we determined the tissue distribution of gamma-chain mRNA expression and the pattern of gamma- chain pre-mRNA processing. The results of in situ hybridization demonstrated that gamma A and gamma B transcripts were localized to and codistributed in liver hepatocytes, indicating that no subset of cells process gamma B mRNA. The ubiquitous expression of the fibrinogen gamma- chain promoter was demonstrated in marrow, lung, brain, and liver by RNase protection using a 5′-specific gamma-chain probe. RNase protection studies to map 3′ RNA processing sites suggested that, in addition to the distal poly(A) signal previously identified, two alternative poly(A) signals within the last intron (ATTAAA and AATAAA) were used only in liver to produce gamma B transcripts. Approximately equal usage of the three poly(A) signals (27%, 37%, and 36%, respectively) to form the 3′ end of mature gamma B transcripts suggested that poly(A) site selection is random. These results indicate that splicing of the last intron to produce gamma A mRNA is the ubiquitous and constitutive pattern of gamma-chain RNA processing, while retention of the last intron to produce gamma B mRNAs is the tissue-specific and regulated pattern of gamma-chain RNA processing. The pattern of rat gamma-chain RNA processing is similar to human, implying that the mechanism is conserved. These data support a mechanism of tissue-specific splice site selection predominating over poly(A) site selection in gamma-chain pre-mRNA processing. The expression of both fibrinogen gamma-chain transcripts in liver, rather than mutually exclusive expression in liver and other tissues, provides a new model for studying tissue-specific alternative 3′ end formation regulatory mechanisms.
Evaluation of long-term antinociceptive properties of stabilized hyaluronic acid preparation (NASHA) in an animal model of repetitive joint pain (2011)

Abstract Introduction Clinical trials provided controversial results on whether the injection of hyaluronan preparations into osteoarthritic joints reduces pain. Problems of clinical studies may be the substantial placebo effects of intra-articular injections, different severity and rate of progression of the disease and others. We hypothesize that the use of preclinical pain models may help to clarify whether a certain hyaluronan exerts antinociceptive effects upon intra-articular injection. In the present study we tested in the bradykinin/prostaglandin E 2 (PGE 2 ) model primarily the putative antinociceptive effect of stabilized hyaluronic acid from a non animal source (NASHA), a stabilized hyaluronic acid based gel for intra-articular treatment of OA. We established a dose-response relationship for NASHA and we compared NASHA to other hyaluronans with different formulations that are in clinical use. Methods To induce transient joint pain episodes bradykinin and PGE 2 were repetitively administered intra-articularly and unilaterally into rat knee joints during short anaesthesia. After establishment of the predrug nociceptive responses, a single intra-articular injection of saline or NASHA at different concentrations was administered and pain responses to further bradykinin/PGE 2 injections were monitored up to 56 days after NASHA. Furthermore, the obtained effective dose was compared to clinically defined concentrations of Hylan GF20 and sodium hyaluronate. The primary outcome measures were primary mechanical hyperalgesia at the knee joint and pain-induced weight bearing. Results On day 1 after injection, all tested hyaluronan preparations showed an antinociceptive effect >50% compared to saline. Single injections of higher doses of NASHA (50, 75 and 100 μl) were antinociceptive up to 56 days. When injection volumes in rat knee joints were adapted to clinical injection volumes in humans, the antinociceptive effects of the cross-linked NASHA and Hylan GF20 had a longer duration than that of the non cross-linked sodium hyaluronate (with a slightly better effect of NASHA than Hylan GF20). Conclusions In the bradykinin/PGE 2 model of joint pain a single injection of all hyaluronan preparations provided significant antinociceptive effects compared to saline. It appeared that the duration of the antinociceptive effect of the cross-linked hyaluronan preparations NASHA and Hylan GF20 was more prolonged. In addition, the gel beads structure allowing only a slow release of hyaluronic acid (NASHA) may even enhance this prolonged antinociceptive effect.
Immolina, a High–Molecular-Weight Polysaccharide Fraction of Spirulina, Enhances Chemokine Expression in Human Monocytic THP-1 Cells (2006)

The results of the experiments demonstrate that Immolina activates THP-1 cells in a manner that is consistent with the recruitment of diverse populations of leukocytes in response to inflammatory and infectious signals.
Genetics and molecular biology of hypotension (1994)

Major strides in the molecular biology of essential hypertension are currently underway. This has tended to obscure the fact that a number of inherited disorders associated with low blood pressure exist and that these diseases may have milder and underrecognized phenotypes that contribute importantly to blood pressure variation in the general population. This review highlights some of the gene products that, if abnormal, could cause hypotension in some individuals. Diseases due to abnormalities in the catecholamine enzymes are discussed in detail. It is likely that genetic abnormalities with hypotensive phenotypes will be as interesting and diverse as those that give rise to hypertensive disorders.
Monovalent cation composition and ATP and lipid content of irreversibly sickled cells (1978)

Abstract Discontinuous Stractan gradients were used to separate heterogeneous populations of sickle cells into discrete subpopulations containing varying proportions of reticulocytes, mature discoid cells, and irreversibly sickled cells (ISC). The improved homogeneity of these preparations, together with an enhanced yield of ISC, allowed us to distinguish effects of cell maturation from those of irreversible sickling. With these cell preparations we have begun to define physical properties of ISC. We confirmed the marked abnormalities in cation composition of native ISC. Measurements of ATP in ISC did not substantiate prior reports of ATP deficits. Finally, no evidence for substantial loss of membrane lipids during the process of ISC formation could be demonstrated.
A moving cell bearer management architecture for LTE-Advanced system (2015)

Mobile data traffic has been predicted to grow exponentially in the next several years due to recent increased penetration of mobile devices running a vast array of mobile applications. Moving cell is a concept to further evolve fixed small cell technology for the next generation wireless system which is solved the rapid increase of traffic. It provides a continuous connection to the mobile network and moves around its connection network along to the user. A moving cell in Long Term Evolution-Advanced (LTE-A) cellular network confers a flexibility to the system and allows for a more enhanced mobility management, and supports heterogeneous radio access technologies simultaneously. It can establish the new bearer type for heterogeneous radio access technologies and improve the quality of service for user and to provide high data rate, low delay, and low power consumption for user mobile equipment. In this paper, we propose a moving cell bearer control mechanism and the architecture of moving cell supported by a LTE-A system for 5 Generation. The cellular network needs to establish a new type of the Evolved Packet System (EPS) bearer for WiFi radio bearer of the moving cell. We describe the entities of this architecture, the protocol stack and describe how user bearers setup.
Frequency-Domain Channel Estimation In Mimo-Ofdm (2004)

Publication in the conference proceedings of EUSIPCO, Viena, Austria, 2004
Apoptosis in osteoarthritis: morphology, mechanisms, and potential means for therapeutic intervention. (2008)

Osteoarthritis (OA) is the most common chronic joint disorder found in the aging population and is primarily characterized by loss of articular cartilage. Because chondrocytes are essential for maintaining the normal matrix of cartilage, a central hypothesis in ongoing studies of cartilage degeneration in OA has focused on the potential role of cell death. Today, chondrocytic death in OA has been examined in various studies, most of which report an increased amount of apoptotic cell death in OA cartilage. Although the role of apoptosis in OA is not yet clear, the mechanism of apoptosis may offer potentially useful therapeutic targets for the management of this insidious disease.
CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ alpha beta T cell pool. (1999)

It is generally accepted that TCR alphabeta+ CD8+ T cells recognize immunogenic peptides bound to MHC-encoded class I molecules. This recognition is a major component of the cellular response mediating immune protection and recovery from viral infections and from certain intracellular bacterial infections. Here, we report two human CD8+ TCR alphabeta+ T cell lines specific for Mycobacterium tuberculosis Ags presented in the context of CD1a or CD1c Ag-presenting molecules. These T cells recognize lipid Ags and display cytotoxicity as well as strong Th cell type I cytokine responses. By extending presentation by the CD1 system to the major TCR alphabeta+ CD8+ T cell pool, this system gains wider applicability beyond the double negative subset of T cells previously shown to have this reactivity. This implies that previous assumptions about the role of CD8+ T cells in microbial immunity may require revision as the relative proportions of CD1-restricted and MHC class I-restricted CD8+ T cells are further defined.
Nonequilibrium plasmons with gain in graphene (2015)

A theoretical evaluation of the dynamic polarizability of graphene in a photoexcited carrier inversion state shows that graphene can support nonequilibrium plasmons with gain. The authors predict that the experimental observation of plasmon amplification in graphene is possible under realistic conditions. This would help overcome the barriers to using graphene in plasmonics due to plasmon losses.
Acute Pulmonary Embolism: Retrospective Cohort Study of the Predictive Value of Perfusion Defect Volume Measured With Dual-Energy CT (2017)

Compared with ventricular diameter ratio alone, lung perfusion defect volume had no statistically significant added benefit for prediction of death of any cause within 30 days or of pulmonary embolism-related death among patients with acute PE.
Design of a singularity-free articulated arm subassembly (1993)

Adding a redundant degree of freedom to the shoulder pointing system complex of an articulated arm subassembly makes it possible to achieve a maximal workspace that is free of singularities. This paper derives a functional constraint between three of the four joints of this new type of arm, achieving a singularity-free workspace encompassing the entire reachable volume between the maximal- and minimal-reach surfaces. The large volume of dexterous workspace is verified by animation of the resulting arm design. Graphical results from the animation are presented comparing the dexterous workspace of this new arm to that of the standard nonredundant articulated arm subassembly found in the Puma manipulator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Measurement and Simulation of the Energy Consumption of a WLAN Interface (2002)

The energy efficiency of a wireless network interface is a major design issue since mobile devices are often constrained by the battery. The work presented here follows the question which parameter of a WLAN interface can be adjusted to improve energy efficiency.We measured the power consumption of a WLAN interface for various operational modes and parameter settings for a non-impaired Radio Frequency (RF) channel and derived the energy consumed to transmit one bit of payload. The power consumption values were used to parameterize a simulation model of the WLAN interface which was in turn used to investigate the influence of parameters like RF power level, packet size, and data rate on the energy efficiency in case the radio channel becomes worse. Additionally, an analytical energy consumption model for a simple case is presented. Our results indicate, that control of the RF power level and data rate adaption have the highest impact on the energy efficiency.
Combined beamforming and scheduling for high speed downlink packet access (2004)

The joint operation of high speed downlink packet access (HSDPA) and adaptive antennas in a WCDMA cellular network is considered. The total throughput per cell of HSDPA depends heavily on the strategy employed by the scheduler. It is argued that the maximum SIR scheduler, which maximizes throughput in the single antenna system by serving only the user with the best momentary channel quality, will not substantially benefit from adaptive antennas due to excess self interference at the receiver. As an alternative a set of scheduling strategies is proposed, which rely on serving simultaneously multiple spatially separated users. System level simulations show that with the spatial division multiple access scheduler it is possible to achieve almost twofold throughput improvement over maximum SIR when using four antennas per sector.
A Characterization of Semilocal Inertial Coefficient Rings (1970)

A commutative ring R with identity is called an inertia!coefficient ring if every finitely generated i?-algebra A with A /N separable over R contains a separable subalgebra 5 such that S-\-N = A, where N is the Jacobson radical of A. Thus inertial coefficient rings are those commutative rings R for which a generalization of the Wedderburn Principal Theorem holds for suitable .R-algebras.Our purpose is to prove that a commutative ring with only finitely many maximal ideals is an inertial coefficient ring (if and) only if it is a finite direct sum of Hensel rings.
Zip6 Transporter Is an Essential Component of the Lymphocyte Activation Machinery (2018)

Zinc deficiency causes immune dysfunction. In T lymphocytes, hypozincemia promotes thymus atrophy, polarization imbalance, and altered cytokine production. Zinc supplementation is commonly used to boost immune function to prevent infectious diseases in at-risk populations. However, the molecular players involved in zinc homeostasis in lymphocytes are poorly understood. In this paper, we wanted to determine the identity of the transporter responsible for zinc entry into lymphocytes. First, in human Jurkat cells, we characterized the effect of zinc on proliferation and activation and found that zinc supplementation enhances activation when T lymphocytes are stimulated using anti-CD3/anti-CD28 Abs. We show that zinc entry depends on specific pathways to correctly tune the NFAT, NF-κB, and AP-1 activation cascades. Second, we used various human and murine models to characterize the zinc transporter family, Zip, during T cell activation and found that Zip6 was strongly upregulated early during activation. Therefore, we generated a Jurkat Zip6 knockout (KO) line to study how the absence of this transporter affects lymphocyte physiology. We found that although Zip6KO cells showed no altered zinc transport or proliferation under basal conditions, under activation, these KO cells showed deficient zinc transport and a drastically impaired activation program. Our work shows that zinc entry into activated lymphocytes depends on Zip6 and that this transporter is essential for the correct function of the cellular activation machinery.
TGF-β1 stimulates cultured human fibroblasts to proliferate and produce tissue-like fibroplasia: A fibronectin matrix-dependent event (1997)

During wound repair, fibroblasts accumulate in the injured area until any defect is filled with stratified layers of cells and matrix. Such fibroplasia also occurs in many fibrotic disorders. Transforming growth factor-beta (TGF-beta), a promotor of granulation tissue in vivo and extracellular matrix production in vitro, is expressed during the active fibroplasia of wound healing and fibroproliferative diseases. Under usual tissue culture conditions, normal fibroblasts grow to confluence and then cease proliferation. In this study, culture conditions with TGF-beta 1 have been delineated that promote human fibroblasts to grow in stratified layers mimicking in vivo fibroplasia. When medium supplemented with serum, ascorbate, proline, and TGF-beta was added thrice weekly to normal human dermal fibroblasts, the cells proliferated and stratified up to 16 cell layers thick within the culture dish, producing a tissue-like fibroplasia. TGF-beta stimulated both DNA synthesis as measured by 3H-thymidine uptake and cell proliferation as measured by a Hoechst dye DNA assay in these postconfluent cultures. The stratification was dependent on fibronectin assembly, as demonstrated by anti-fibronectin antibodies which inhibited both basal and TGF-beta-stimulated cell proliferation and stratification. Suppression of collagen matrix assembly in cell layers with beta-amino-proprionitrile (BAPN) did not inhibit basal or TGF-beta stimulated in vitro fibroplasia. BAPN did not interfere with fibronectin matrix assembly as judged by immunofluorescence microscopy. Thus, in concert with serum factors, TGF-beta stimulates postconfluent, fibronectin matrix-dependent, fibroblast growth creating a fibroplasia-like tissue in vitro.
Chemical Constituents of Dysoxylum binectariferum (2010)

Objective: To isolate the chemical constituents from the stem bark of Dysoxylum binectariferum and identify their structures.Methods: The powdered stem bark of D.binectariferum were extracted with 95% ethanol and purified by silica gel,RP-C18 and Sephadex LH-20 column chromatograph and HPLC.The chemical structures were elucidated on the basis of spectroscopic analysis.Results: Five compounds were isolated from the stem bark of D.binectariferum including three Sesquiterpenes.The five compounds were identified as 10β,15-Hydroxy-T-muurolol(1),10β,15-Hydroxy-α-cadinol(2),10α,15-Hydroxy-α-cadinol(3),Isoscopoletin(4),3,4-Dimethoxybenzyl alcohol(5),respectively.Conclusion: Compounds 1,2,4,5 are isolated from the genus of Dysoxylum for the first time.