gebhart/patrepeval huggingface dataset:
Interactions of Silver Nanoparticles with <i>Pseudomonas putida</i> Biofilms (2009)

Silver nanoparticles (Ag NPs) may present a risk to the environment due to their expected toxicity and wide exposure. The interactions between Ag NPs and laboratory-grown Pseudomonas putida biofilms were investigated under a range of environmentally relevant conditions (pH 6 and 7.5; presence and absence of Suwannee River fulvic acid (SRFA)) over 4 days. In the absence of SRFA, there was extensive sloughing of the biofilm bacteria into suspension implying NP-bacterial interactions and potential effects on NP transport in the environment. In the presence of SRFA, sloughing of cells into suspension was reduced under some conditions and Ag NPs and their aggregates were observed and quantified on and in the bacterial cells in the biofilm. Viability of the cells in all cases appear unchanged by the presence of Ag NPs. Cell viability was independent of the concentration of NPs in solution, but sloughing rates varied substantially, sometimes in a dose-dependent manner. The results suggest that biofilms are impacted by Ag NPs when SRFA was not present, and that SRFA increases uptake and bioaccumulation of Ag NPs to biofilms, perhaps resulting in longer term effects, which need further investigation.
Sorption and transport in glassy polymers–a review (1980)

Abstract After defining Fickian diffusion in rubbery polymers an overview of transport behavior in polymers is presented. Diffusion and sorption below the glass transition are discussed, followed by a review and classification of the various theoretical models which have been proposed to account for these phenomena. A short list of recommendations for future work is included.
Adipose stem cells and their paracrine factors are therapeutic for early retinal complications of diabetes in the Ins2Akita mouse (2018)

ASCs or their secreted factors mitigate retinal complications of diabetes in the Ins2<sup>Akita</sup> model. Further investigation is warranted to determine whether ASCs or their secreted factors are safe and effective therapeutic modalities long-term as current locally delivered therapies fail to effectively mitigate the progression of early-stage DR. Nonetheless, our study sheds new light on the therapeutic mechanisms of adult stem cells, with implications for assessing relative risks/benefits of experimental regenerative therapies for vision loss.
Cross polarization during clear‐air conditions on terrestrial links: A review (1981)

This paper reviews experimental and theoretical research on cross polarization that occurs during clear‐air conditions on terrestrial microwave links. After consideration of the various clear‐air mechanisms that have been suggested, the conclusion is drawn that multipath mechanisms interacting with the cross‐polarized patterns of the antennas are the most important. Theoretical models that explain these mechanisms and semi‐empirical models that characterize the cross‐polarized signal statistics are then discussed. Particular attention is given to the semi‐empirical models since they can be used most readily for statistical predictions in design applications. Some new insight into the similarities and differences between models developed in France, Japan, and the United States is provided. Finally, application of the semi‐empirical models in the design of digital systems is briefly considered, and the relative importance of cross polarization during clear‐air and precipitation conditions is discussed.
Modulation of RNA Splicing for the Treatment of Cancer (2019)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTModulation of RNA Splicing for the Treatment of CancerRobert B. Kargbo*Robert B. KargboUsona Institute, 277 Granada Drive, San Luis Obispo, California 93401-7337, United States*E-mail: [email protected]More by Robert B. Kargbohttp://orcid.org/0000-0002-5539-6343Cite this: ACS Med. Chem. Lett. 2020, 11, 1, 7–8Publication Date (Web):December 23, 2019Publication History Received8 December 2019Published online23 December 2019Published inissue 9 January 2020https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00585https://doi.org/10.1021/acsmedchemlett.9b00585editorialACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1808Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (433 KB) Get e-AlertscloseSUBJECTS:Biopolymers,Cancer,Cancer therapy,Gene therapy,Genetics Get e-Alerts
Advances in Imaging (2011)

Modern radiation oncology relies heavily on emerging technology. In this article, we review recent advances in target delineation as it applies to radiation treatment planning. We focus on the evidence to support methionine positron emission tomography use for target delineation in primary brain tumors, 2-deoxy-2-[(18)F] fluoro-D-glucose positron emission tomography use for target delineation for lung cancer and head and neck cancer, and the use of magnetic resonance imaging sequences for target delineation in prostate cancer.
The Effects of Gravity on Wrinkled Laminar Flames (1992)

The effects of gravity are significant to the dynamics of idealized unconfined open premixed flames. Moderate to low turbulence Reynolds number flames, i.e., wrinkled laminar flames, of various unconfined geometries have been used extensively for investigating fundamental processes of turbulent flame propagation and to validate theoretical models. Without the wall constraints, the flames are free to expand and interact with surrounding ambient air. The flow field in which the flame exists is determined by a coupling of burner geometry, flame orientation and the gravity field. These complex interactions raise serious questions regarding the validity of comparing the experimental data of open flames with current theoretical and numerical models that do not include the effects of gravity nor effects of the larger aerodynamic flowfield. Therefore, studies of wrinkled laminar flame in microgravity are needed for a better understanding of the role of gravity on flame characteristics such as the orientation, mean aerodynamics stretch, flame wrinkle size and burning rate. Our approach to characterize and quantify turbulent flame structures under microgravity is to exploit qualitative and quantitative flow visualization techniques coupled with video recording and computer controlled image analysis technologies. The experiments will be carried out in the 2.2 second drop tower at the NASA Lewis Research Center. The longest time scales of typical wrinkled laminar flames in the geometries considered here are in the order of 10 msec. Hence, the duration of the drop is sufficient to obtain the amount of statistical data necessary for characterize turbulent flame structures.
Formation of Al2O3-Cu Composite Particles and Influence of Oxygen for the Mechanofusion. (1992)

Using the vacuum mechanofusion apparatus which has been reported. we tried to coat
Art in New Mexico, 1900–1945: Paths to Taos and Santa Fe by Charles C. Eldredge, Julie Schimmel, and William T. Truettner (1987)

Reviews 85 Art in New Mexico, 1900-1945: Paths to Taos and Santa Fe. By Charles C. Eldredge, Julie Schimmel, and William T. Truettner. (New York: Abbeville Press, 1986. 227 pages, $45.00.) The physical format is coffee-table art book; the authors, who have written individual essay-chapters, are staff members of the Smithsonian. Art in New Mexico, 1900-1945: Paths to Taos and Santa Fe speaks from the meta-authority of form (over half of the 200 illustrations are in representative color tones) ; and of content (the essay-chapters draw from impressive crossdisciplinary sources of archaeology, literature, and popular culture). The first and last essay headings—“Beyond the Picturesque” to “The Faraway Nearby” —intimate the metaphorical range of the study because above all, this book is about the most elemental of the western American consciousness—space. Dur­ ing this time and in the places of Taos and Santa Fe, something original occurred that since 1945 has not been duplicated with the same intensity and purity of purpose. The relationship of the New Mexico space to all that occurred within, or as a part of it from without, is the study’s inviting argument. During these forty-five years, New Mexico represented a united cultural effort of scholars and artists who struggled on paper and on canvas to maintain the unity of the subject-object question: the Pueblo Indians and myth, the Hispanics and Catholicism, religion and sentiment, the unity of modern man with primeval space, the fragmentation of space with modernism. This study, published for a 1986-87 touring exhibition by the same name, is itself “Beyond the Picturesque” by bringing into perspective, if not view, “The Faraway Nearby” of a land where artists and scholars, before World War II, meted cultural understanding with the clarity of vision of a land whose dignity was found in its geometry, in its awesome expanse of space, and in its diverse people. These people, in New Mexico, had a meeting of minds under the auspices of earth and sky. The many voices of this study’s authority speak clearly and poetically, merging scholarship and art into one informative rhetorical medium. PAMELA R. HOWELL Midland College River Runners of the Grand Canyon. By David Lavender. (Tucson: Grand Canyon Natural History Association and University of Arizona Press, 1986. 147 pages, $27.50.) The next best thing to being in the Grand Canyon is to read David Lavender’s finely researched book on the men and women who floated, rowed, bashed, capsized, white-knuckled and caroomed their way from Cataract Canyon to Diamond Creek. ...
Low-dose retinoid therapy for chemoprophylaxis of skin cancer in renal transplant recipients. (1998)

Low dose etretinate is safe, well-tolerated and partially effective in chemoprophylaxis of skin cancer in renal transplant recipients.
Health, nutrition and demand for food: an American perspective. (2003)

This chapter deals with the methodology for incorporating the consumer's health information into a food demand model for analysing consumption behaviour. It also discusses the method of creating proxy variables to quantify both the amount and changing trends of consumer health information over time. Trends in food consumption and expenditure in the USA are presented. The approaches employed by researchers that extend the neoclassical model to incorporate health into a demand model are also reviewed.
Cancer Cell Cycle Modulated by a Functional Coupling between Sigma-1 Receptors and Cl– Channels (2006)

The sigma-1 receptor is an intracellular protein characterized as a tumor biomarker whose function remains mysterious. We demonstrate herein for the first time that highly selective sigma ligands inhibit volume-regulated chloride channels (VRCC) in small cell lung cancer and T-leukemia cells. Sigma ligands and VRCC blockers provoked a cell cycle arrest underlined by p27 accumulation. In stably sigma-1 receptor-transfected HEK cells, the proliferation rate was significantly lowered by sigma ligands when compared with control cells. Sigma ligands produced a strong inhibition of VRCC in HEK-transfected cells but not in control HEK. Surprisingly, the activation rate of VRCC was dramatically delayed in HEK-transfected cells in the absence of ligands, indicating that sigma-1 receptors per se modulate cell regulating volume processes in physiological conditions. Volume measurements in hypotonic conditions revealed indeed that the regulatory volume decrease was delayed in HEK-transfected cells and virtually abolished in the presence of igmesine in both HEK-transfected and T-leukemic cells. Moreover, HEK-transfected cells showed a significant resistance to staurosporine-induced apoptosis volume decrease, indicating that sigma-1 receptors protect cancer cells from apoptosis. Altogether, our results show for the first time that sigma-1 receptors modulate "cell destiny" through VRCC and cell volume regulation.
MOCVD epitaxy of <b> <i>β</i> </b>-(AlxGa1−x)2O3 thin films on (010) Ga2O3 substrates and N-type doping (2019)

(010) β-(AlxGa1−x)2O3 thin films were grown on (010) β-Ga2O3 substrates via metalorganic chemical vapor deposition with up to 40% Al incorporation by systematic tuning of the Trimethylaluminum (TMAl)/triethylgallium molar flow rate ratio and growth temperature. High crystalline quality with pure β-phase (AlxGa1−x)2O3 was achieved for films with Al composition x &lt; 27%, while a higher Al composition induced phase segregation which was observed via X-ray diffraction spectra. Al incorporation was highly dependent on the growth temperature, chamber pressure, oxygen partial pressure, and TMAl molar flow rate. Atomic resolution scanning transmission electron microscopy (STEM) imaging demonstrated a high crystalline quality β-(Al0.15Ga0.85)2O3 film with an epitaxial interface. High resolution STEM imaging of (AlxGa1−x)2O3/Ga2O3 superlattice (SL) structures revealed superior crystalline quality for the 23% Al composition. When the Al composition reaches 40%, the SL structure maintained the β-phase, but the interfaces became rough with inhomogeneous Al distribution. N-type doping using Si in β-(AlxGa1−x)2O3 films with the Al composition up to 33.4% was demonstrated.
MPEG System Streams in Best-Effort Networks (1999)

The MPEG format is widely used and therefore an attractive vehicle for the distribution of video and audio material over the Internet. However, the hierarchical structure of MPEG systems complicates the task of delivering continuous, synchronized streams of video and audio in a best-effort environment (today&apos;s Internet). If the network throws away packets on encountering congestion, the video and audio stream may loose synchronization for a number of frames. Therefore, adapting the resource demands of an MPEG system must be done by an entity that is knowledgeable of the MPEG system structure: an MPEG system filter. This paper describes the integration of such an MPEG system filter into a network. Our experience to date indicates that mid-range PCs can host such a filter, and that the filter succeeds in adapting the resource requirements of an MPEG system in response to changes in the network load.
Portable Precision Frequency Meter (1949)

The portable frequency meter proposed in this report measures any frequency in the range of 5 Mc to 1407 Mc to an accuracy within three parts per million, 0.0003 percent. This self-contained frequency meter provides a stable comparison frequency of known calibration which is compared with the unknown frequency through a crystal mixer, video amplifier type receiver, and the unknown is identified by the use of the associated filter and indicator circuits. The stable oscillator is positioned by an automatic frequency control loop consisting primarily of a direct reading, four decade frequency divider, a phase discriminator, a reactance tube, and a temperature controlled crystal oscillator which provides a very stable control frequency at the phase discriminator. Frequency change of the positioned oscillator is made by switching of the four decade divider controls. The proposed frequency meter will require no external calibration curves or tables, but will present the frequency reading on the front panel in the form of a very simple frequency equation. Operation of the meter will be simple and direct.
A novel high sensitive laser diode sensor based on micro-cavity (2016)

In this paper, we have proposed and demonstrated a high sensitive half ring laser sensor with a deep etched-sensing region based on III-V semiconductor. A whispering gallery mode propagates along the deep etched boundary of the HRL by the deep etched mirror at the edge of the HRL. In addition, the lasing direction of the proposed sensors is controlled by the reflection coefficient of the deep etched mirror at the side of the micro-cavity. The proposed sensors have advantages that an enhanced Q-factor by a stimulated emission and a controllable lasing direction for simplified alignment system. Additionally, the ultra-small variation of the effective refractive index according to molecules interactions could be sensitively detected with the proposed sensors using by a long evanescent field at the deep etched sensing region.
Intercomparison of five PM10 monitoring devices and the implications for exposure measurement in epidemiological research (2000)

Five different instruments for the determination of the mass concentration of PM10 in air were compared side-by-side for up to 33 days in an undisturbed indoor environment: a tripod mounted BGI Inc. PQ100 gravimetric sampler with a US EPA certified Graseby Andersen PM10 inlet; an Airmetrics Minivol static gravimetric sampler; a Casella cyclone gravimetric personal sampler; an Institute of Occupational Medicine gravimetric PM10 personal sampler; and two TSI Inc. Dustrak real-time optical scattering personal samplers. For 24 h sampling of ambient PM10 concentrations around 10 microg m(-3), the estimated measurement uncertainty for the two gravimetric personal samplers was larger (approximately +/- 20%) compared with estimated measurement uncertainty for the PQ100/Graseby Andersen sampler (< +/- 5%). Measurement uncertainty for the Dustraks was lower (approximately +/- 15% on average) but calibration of the optical response against a reference PM10 method is essential since the Dustraks systematically over-read PM10 determined gravimetrically by a factor approximately 2.2. However, once calibrated, the Dustrak devices demonstrated excellent functionality in terms of ease of portability and real-time data acquisition. Estimated measurement uncertainty for PM10 concentrations determined with the Minivol were +/- 5%. The Minivol data correlated well with PQ100/Graseby Andersen data (r= 0.97, n = 18) but were, on average, 23% greater. The reason for the systematic discrepancy could not be traced. Intercomparison experiments such as these are essential for assessing measurement error and revealing systematic bias. Application of two Dustraks demonstrated the spatial and temporal variability of exposure to PM10 in different walking and transport microenvironments in the city of Edinburgh, UK. For example, very large exposures to PM10 were identified for the lower deck of a double-decker tour bus compared with the open upper deck of the same vehicle. The variability observed emphasises the need to determine truly personal exposure profiles of PM10 for quantifying exposure response relationships for epidemiological studies.
Reconstitution in vitro of RNase H activity by using purified N-terminal and C-terminal domains of human immunodeficiency virus type 1 reverse transcriptase. (1991)

Two constituent protein domains of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase were expressed separately and purified to homogeneity. The N-terminal domain (p51) behaves as a monomeric protein exhibiting salt-sensitive DNA polymerase activity. The C-terminal domain (p15) on its own has no detectable RNase H activity. However, the combination of both isolated p51 and p15 in vitro leads to reconstitution of RNase H activity on a defined substrate. These results demonstrate that domains of HIV-1 reverse transcriptase are functionally interdependent to a much higher degree than in the case of reverse transcriptase from Moloney murine leukemia virus.
Detection of 4-Hydroxy-2-Nonenal- and 3-Nitrotyrosine-Modified Proteins Using a Proteomics Approach (2009)

Oxidative stress has been shown to be one of the mechanisms involved in a number of diseases, including neurodegenerative disorders, ischemia, cancer, etc. Oxidative stress occurs mainly due to an imbalance between oxidant and antioxidant systems. Oxidants can damage virtually all biological molecules including DNA, RNA, cholesterol, lipids, carbohydrates, proteins, and antioxidants. The oxidative modification of proteins has been shown to play an important role in a number of human diseases. And the methods to identify specific proteins that are susceptible to 4-hydroxy 2-nonenal (HNE) and 3-nitrotyrosine (NT) modifications are limited and difficult. Our laboratory uses two-dimensional polyacrylamide gel electrophoresis (2DE) in combination with western blotting to identify the specific targets of protein nitration and lipid peroxidation. This may require the analysis of thousands of individual proteins from cells and tissues, and coupling of mass spectrometry to this technique allows the identification of proteins. Since the protein levels and the protein oxidation can be obtained from 2DE and 2D blots, specific nitration or HNE modification of each protein spot can be easily calculated.
Electrical Stimulation in Treatment of Delayed Union and Nonunion of Fractures and Osteotomies (1984)

This study reviews the cases of 52 patients with 52 ununited fractures and osteotomies who were treated with two methods of electrical stimulation, one surgical, the other nonsurgical. Seventeen patients, 14 of whom had concomitant bone grafting, had implantation of a bone growth stimulator. There were three synovial pseudarthroses but no active infection in this group. The overall success rate in healing of the fractures was 82%. Thirty-five patients, of whom four had initial concomitant bone grafting, were treated with pulsing electromagnetic fields (PEMF). There were six draining infections but no pseudarthrosis in this group. Two nonunions healed after bone grafting was combined with PEMF treatment, when the latter alone had failed. Eighty-one percent of the fractures united, and drainage ceased in five of the six infections.
Secure Group communication in Body Area Networks (2008)

Body Area Network (BAN) is an emerging technology which receives significant interest recent years. Typical BAN applications include healthcare, military, sports and first-responder. There is a great need to make BAN data transmission secure, accurate and protected. This paper presents a two-tier Secure Group communication framework (SG-BAN) for BAN data exchange, file sharing and remote display. Secure communication within a BAN (intraBAN) and between BANs (interBAN) are supported. At the interBAN level, group keys are issued/revoked when members join/leave the group to ensure the security policy. At the intraBAN level, device keys and Media Access Control (MAC) addresses are combined to secure communication within a BAN. The performance of the prototype is also presented.