gebhart/patrepeval huggingface dataset:
Higher-order suppressed phase zone plates (1985)

A new phase zone plate with suppressed higher-order flux is proposed and optimum design calculations are made for Al. While the first-order collecting efficiency is equal to that of conventional Fresnel zone plates (∼10%), the ratio of the higher-order flux energy to the first-order energy can be suppressed to <10−3–10−6 in the 300–600-Å wavelength range.
ChemInform Abstract: RACEMISIERUNG BEI PEPTIDSYNTH. (1970)

Abstract Durch Anwendung mehrerer gaschromatographischer Racemisierungstests wurde gefunden, daß bei der Dicyclohexylcarbodiimid‐Methode aus einer Reihe von N‐Hydroxyverbindungen als Zusatz zum Dicyclohexylcarbodiimid das Benzotriazin (I) die Racemisierung am wirkungsvollsten senkt.
Preparation and Properties of Several Cyclohexyl-alkyl-substituted Ketene Dimers (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and Properties of Several Cyclohexyl-alkyl-substituted Ketene DimersCarl M. Hill and Gilbert W. SenterCite this: J. Am. Chem. Soc. 1949, 71, 1, 364–365Publication Date (Print):January 1, 1949Publication History Published online1 May 2002Published inissue 1 January 1949https://pubs.acs.org/doi/10.1021/ja01169a506https://doi.org/10.1021/ja01169a506research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of a Transformation System in Streptomyces virginiae. (1997)

Streptomyces virginiae is one of the most difficult Streptomyces strains to transform because of its strong restriction barrier. We succeeded in transforming S. virginiae by combining heat treatment of protoplasts and in vitro methylation of plasmids. In order to avoid the host restriction barrier, plasmids were modified by methylase AluI, and S. virginiae protoplasts were treated at 42°C for 15 min prior to transformation. Under the optimal conditions, plasmids pIJ486, pKC1064 and pUWL-KS isolated from Streptomyces lividans were introduced into S. virginiae at a frequency of 1.4×103, 7.0×102 and 1.2×103 transformants per μg DNA, respectively. Plasmid pKC1064 and pUWL-KS isolated from Escherichia coli DH5α could not transform S. virginiae, but those isolated from E. coli JM110 (dam, dcm) could transform at a frequency of 1.0×102 and 2.4×102 transformants per μg DNA, indicating the presence of a methylation-specific restriction system in S. virginiae.
Self‐Assembly of Hydrophilic Homopolymers: A Matter of RAFT End Groups (2011)

Unusual self-assembly behavior is observed for a range of hydrophilic homopolymers. This self-assembly behavior is contrary to the expected behavior of such hydrophilic polymers and instead mimics more commonly reported amphiphilic block copolymers. It is proposed that the unique combination of hydrophobic end groups at both the α and ω chain end accounts for this unusual self-assembly behavior. Complex internal polymer micelles are spontaneously formed when hydrophilic homopolymer polyelectrolytes and neutral polymers (with a weight fraction of the hydrophobic end groups <10 wt%) are directly dissolved in water. The homopolymers, poly[2-(diethylamino)ethyl methacrylate], poly(N-isopropylacrylamide), and poly(ethoxyethylacrylate) are synthesized by reversible addition-fragmentation chain-transfer (RAFT) polymerization using S'-1-dodecyl-(S')-(α,α'-dimethyl-α″-acetic acid) trithiocarbonate (DDMAT) and its derivatives as chain transfer agents (CTAs). A range of polyelectrolyte homopolymers with different terminal groups are designed and synthesized, which under acidic aqueous solution direct the self-assembly to form well-defined nanostructures. This assembly behavior was also observed for neutral polymers, and it was determined that the structure of the hydrophobic end groups (and thus choice of RAFT CTA) are very important in facilitating this unusual self-assembly behavior of hydrophilic homopolymers. It is proposed that the functionality of commonly used CTAs such as DDMAT, can affect the solution association of the resultant homopolymers and can in fact afford ABA' type polymers, which can undergo self-assembly to form higher-order nanostructures.
Functional Activity of an HIV-1 Neutralizing IgG Human Monoclonal Antibody: ADCC and Complement-Mediated Lysis (1992)

The IgG1 kappa, human monoclonal antibody (HMAb), F105, was studied for functional activity in antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). F105 reacts with a discontinuous epitope on the CD4 binding site of the HIV-1 envelope glycoprotein, gp120, expressed on the surfaces of infected cells and neutralizes diverse viral strains at antibody concentrations readily achievable in humans. Neither F105 nor serum (diluted 1:50) from HIV seropositive donors mediate CDC against an SF2-infected cell line with rabbit or human sera as a source of complement. F105 and HIV-1 sera mediate ADCC against the SF2 strain. Normal human serum reduced spontaneous lysis of SF2 by peripheral blood monocytes (PBM). Although mixing of F105 with normal human serum reduced the lysis observed (36 +/- 8 vs. 42 +/- 8%), this still was significantly greater than lysis in media (30 +/- 5%) or normal human serum (23 +/- 6%) (p less than .05). A murine antibody to CD16 significantly reduced spontaneous lysis observed with media (30 +/- 5 vs. 18 +/- 3%) while normal mouse serum had no effect (31 +/- 7%). ADCC mediated by F105 is completely abrogated by the anti-CD16 antibody (42 +/- 8 vs. 22 +/- 4%), while only a fraction of ADCC mediated by HIV sera is inhibited by anti-CD16 (60 +/- 9 vs. 46 +/- 6%), suggesting that several populations of effector cells function in ADCC mediated by the polyclonal sera. Thus, F105, as opposed to polyclonal sera, mediates ADCC through a CD16+ PBM population.
Effect of Using Unbonded Capping Systems on the Compressive Strength of Concrete cylinders (1987)

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Stereo-, chemo-, and regioselective reductions of carbonyl groups via the lithium di-n-butyl-9-borabicyclo[3.3.1]nonane "ate" complex (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereo-, chemo-, and regioselective reductions of carbonyl groups via the lithium di-n-butyl-9-borabicyclo[3.3.1]nonane "ate" complexYoshinori Yamamoto, Hiroo Toi, Akio Sonoda, and Shunichi MurahashiCite this: J. Am. Chem. Soc. 1976, 98, 7, 1965–1967Publication Date (Print):March 1, 1976Publication History Published online1 May 2002Published inissue 1 March 1976https://pubs.acs.org/doi/10.1021/ja00423a055https://doi.org/10.1021/ja00423a055research-articleACS PublicationsRequest reuse permissionsArticle Views203Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Morphological Study of the Effect of the Cavitron Ultrasonic Surgical Aspirator System Near Human Peripheral Nerves (1987)

The Cavitron ultrasonic surgical aspirator system was used to clear superficial tissue from the greater auricular nerve in four human subjects. Following stimulation, the nerves were removed together with an untreated section and processed for examination by light microscopy. Significant damage had been sustained by these nerves, which was not apparent in the control sections. Disruption of the perineurium, intraneural hemorrhage, endoneural edema, and degenerative changes of the myelinated nerve fibers were seen. Damage to neural tissue was evident 0.5 to 1.5 mm in advance of the point of contact with the cutting tip.
A New Approach Towards (\pm)-4-Ipomeanol and Its 2-Furyl Regioisomer (2005)

The cytotoxic furan derivative (\\pm)-4-ipomeanol (1) and its regioisomer (8) were prepared in a new and efficient way starting from commercially available furan derivatives. In both cases the key step was a regioselective solvolysis of the terminal double bond with trifluoroacetic anhydride and boron trifluoride. The resulting compounds were tested in an agar diffusion assay against several bacteria and fungi, but did not show significant activity.
A guided radio system using CATV amplifiers and pressure taps on CATV cable to feed distributed antennas (1985)

CATV equipment is being used for boosting radio signals in 155 mHz mobile systems in Canada and in a 380 mHz system in Saudi Arabia. Recently, CATV line extender amplifiers with passband frequency response beyond 500 mHz have become available and are suitable for boosting VHF and UHF radio signals. Several UHF radio signal booster systems have been installed and are operating in cargo containerships. Economical radio signal booster systems can be constructed using cavity filters for selectivity, CATV line extender amplifiers for amplifying the radio signals, and inexpensive CATV cable for transmission lines with pressure taps attached to feed distributed antennas. CATV equipment is very reliable, the enclosures are gasketed to exclude dust and moisture, power for the amplifiers is carried by the coaxial cable, the equipment is mass produced and it is inexpensive. The amplifiers can be readily type accepted to comply with FCC Rules and Regulations.
Interactive Wormhole Detection and Evaluation (2007)

Wormhole attacks in wireless networks can severely deteriorate network performance and compromise security through spoiling the routing protocols and weakening the security enhancements. This paper develops an approach, interactive visualization of wormholes (IVoW), to monitor and detect such attacks in large-scale wireless networks in real time. We characterize the topology features of a network under wormhole attacks through the node position changes and visualize the information at dynamically adjusted scales. We integrate an automatic detection algorithm with appropriate user interactions to handle complicated scenarios that include a large number of moving nodes and multiple wormhole attackers. Various visual forms have been adopted to assist in the understanding and analysis of reconstructed network topology and to improve the detection accuracy. Extended simulation has demonstrated that the proposed approach can effectively locate the fake neighbor connections without introducing many false alarms. IVoW does not require the wireless nodes to be equipped with any special hardware, thus avoiding any additional cost. We have performed user studies to evaluate the effectiveness of our approach and demonstrate that visual analysis can be successfully combined with network security mechanisms to greatly improve intrusion detection capabilities.
Strategic management 7th edition (2014)

Elderly patients (> or = 65 years) with malignant brain tumors are diagnosed as promptly as younger patients, although they have a markedly different constellation of symptoms. Since diagnosis of brain tumors continues to improve in the elderly, it may be more difficult to ascribe the steady increase in incidence to artifactual factors.
Monovalent Gb3-/Gb2-Derivatives Conjugated with a Phosphatidyl Residue: A Novel Class of Shiga Toxin-Neutralizing Agent (2007)

Shiga toxin (Stx) exerts toxic activity by binding to glycosphingolipids, mainly globotriaosyl (Gb(3)) ceramide, on the surface of target cells. The inhibition of toxin-receptor binding is a promising therapeutic approach to prevent Stx-mediated diseases. In this study, we synthesized monovalent Stx-ligands of phosphatidylethanolamine dipalmitoyl-Gb(3) (Gb(3)-PEDP) and galabiosyl (Gb(2))-PEDP and we examined their neutralizing activity against Stx-1 and Stx-2 in vitro. Both Gb(3)-PEDP and Gb(2)-PEDP strongly neutralized the cytotoxicity of Stx-1 and Stx-2. It is likely that the mechanism of neutralization involved formation of liposomes and consequently clustering of sugar units. We propose monovalent Gb(3)-/Gb(2)-derivatives conjugated with phosphatidyl residue as a novel class of Stx-neutralizing agent.
Tracing the hemangioblast during embryogenesis: developmental relationships between endothelial and hematopoietic cells (2005)

We review here the development of the hematopoietic system and its relationship to the endothelium, with a special focus on the characterisation of the hemangioblast, the putative ancestor for endothelial cells and hematopoietic cells. Using the avian model, we have traced in vivo the progeny of embryonic endothelial cells and shown that aortic-born hematopoietic cells (known to generate the definitive hematopoietic lineage) derive from endothelial cells in the floor of the aorta. During this process, endothelial cells undergo a switch from endothelial cells to hematopoietic cells characterised by a downgrading of endothelial cell-specific genes and the parallel upgrading of hematopoietic cell-specific genes. Using a similar approach, we have shown that generation of hematopoietic cells from endothelial cells also takes place during mouse embryonic development. We have thoroughly characterised the dynamics of key molecules (several of which we have cloned) specifically expressed by the yolk sac or aortic hemangioblast. The yolk sac hemangioblast is characterized by the specific expression of SCL/Tal-1 and Lmo2, whereas the aortic hemangioblast expresses Runx-1 (a runt domain transcription factor). Finally, we have demonstrated the existence of a new site for hematopoiesis, namely the allantois. Using quail/chick grafts, we show that this embryonic appendage autonomously produces endothelial cells and hematopoietic cells, these latter being endowed with the attributes of the definitive hematopoietic lineage.
Dissociation and Reassembly of the Vacuolar H+-ATPase Complex from Oat Roots (1992)

Conditions for the dissociation and reassembly of the multi-subunit vacuolar proton-translocating ATPase (H(+)-ATPase) from oat roots (Avena sativa var Lang) were investigated. The peripheral sector of the vacuolar H(+)-ATPase is dissociated from the membrane integral sector by chaotropic anions. Membranes treated with 0.5 molar KI lost 90% of membrane-bound ATP hydrolytic activity; however, in the presence of Mg(2+) and ATP, only 0.1 molar KI was required for complete inactivation of ATPase and H(+)-pumping activities. A high-affinity binding site for MgATP (dissociation constant = 34 micromolar) was involved in this destabilization. The relative loss of ATPase activity induced by KI, KNO(3), or KCl was accompanied by a corresponding increase in the peripheral subunits in the supernatant, including the nucleotide-binding polypeptides of 70 and 60 kilodaltons. The order of effectiveness of the various ions in reducing ATPase activity was: KSCN > KI > KNO(3) > KBr > K-acetate > K(2)SO(4) > KCl. The specificity of nucleotides (ATP > GTP > ITP) in dissociating the ATPase is consistent with the participation of a catalytic site in destabilizing the enzyme complex. Following KI-induced dissociation of the H(+)-ATPase, the removal of KI and MgATP by dialysis resulted in restoration of activity. During dialysis for 24 hours, ATP hydrolysis activity increased to about 50% of the control. Hydrolysis of ATP was coupled to H(+) pumping as seen from the recovery of H(+) transport following 6 hours of dialysis. Loss of the 70 and 60 kilodalton subunits from the supernatant as probed by monoclonal antibodies further confirmed that the H(+)-ATPase complex had reassembled during dialysis. These data demonstrate that removal of KI and MgATP resulted in reassociation of the peripheral sector with the membrane integral sector of the vacuolar H(+)-ATPase to form a functional H(+) pump. The ability to dissociate and reassociate in vitro may have implications for the regulation, biosynthesis, and assembly of the vacuolar H(+)-ATPase in vivo.
Aggregate Breakup in a Contracting Nozzle (2009)

The breakup of dense aggregates in an extensional flow was investigated experimentally. The flow was realized by pumping the suspension containing the aggregates through a contracting nozzle. Variation of the cluster mass distribution during the breakage process was measured by small-angle light scattering. Because of the large size of primary particles and the dense aggregate structure image analysis was used to determine the shape and structure of the produced fragments. It was found, that neither aggregate structure, characterized by a fractal dimension d(f) = 2.7, nor shape, characterized by an average aspect ratio equal to 1.5, was affected by breakage. Several passes through the nozzle were required to reach the steady state. This is explained by the radial variation of the hydrodynamic stresses at the nozzle entrance, characterized through computational fluid dynamics, which implies that only the fraction of aggregates whose strength is smaller than the local hydrodynamic stress is broken during one pass through the nozzle. Scaling of the steady-state aggregate size as a function of the hydrodynamic stress was used to determine the aggregate strength.
Anti-Cytokine Therapy for the Treatment of Graft-Versus-Host Disease (2004)

Acute graft-versus-host disease (GVHD) and chronic GVHD remain the major barriers to successful hematopoietic cell transplantation. The induction of GVHD may be divided into three phases--(I) recipient conditioning, (II) donor T cell activation, and (III) effector cells mediating GVHD. Cytokines have been shown to be extremely important in the initiation and propagation of GVHD. Of note, IL-2 and TNF-alpha lead to cellular activation as well as local tissue damage. There has been a major development in the last few years of monoclonal antibodies that target cytokines. Drugs that target the IL-2 receptor (daclizumab and basiliximab) are now commonly used to prevent renal transplant rejection. Furthermore, drugs that target TNF-alpha (infliximab and etanercept) are used in rheumatoid arthritis and Crohn's disease but are also being tested for a number of other autoimmune diseases. These agents are very selective immunosuppressants that have different mechanisms of action than the calcineurin inhibitors and therefore are potentially promising for treatment or prevention of GVHD. The authors present up-to-date data regarding the use and development of anti-cytokine therapy for GVHD. The most effective approach to GVHD prevention will likely be a combination regimen where the three phases of the GVHD cascade are disrupted. Once GVHD has occurred, all three phases of the cascade are activated. Developments of combination therapy for treatment of both acute and chronic GVHD will likely yield better results than monotherapy. The numerous new treatment modalities presented should improve the outlook for acute and chronic GVHD.
MEIOTIC RECOMBINATION BETWEEN DUPLICATED GENETIC ELEMENTS IN <i>SACCHAROMYCES CEREVISIAE</i> (1985)

We have studied the meiotic recombination behavior of strains carrying two types of duplications of an 18.6-kilobase HIS4 Bam HI fragment. The first type is a direct duplication of the HIS4 Bam HI fragment in which the repeated sequences are separated by Escherichia coli plasmid sequences. The second type, a tandem duplication, has no sequences intervening between the repeated yeast DNA. The HIS4 genes in each region were marked genetically so that recombination events between the duplicated segments could be identified. Meiotic progeny of the strains carrying the duplication were analyzed genetically and biochemically to determine the types of recombination events that had occurred. Analysis of the direct vs. tandem duplication suggests that the E. coli plasmid sequences are recombinogenic in yeast when homozygous. In both types of duplications recombination between the duplicated HIS4 regions occurs at high frequency and involves predominantly interchromosomal reciprocal exchanges (equal and unequal crossovers). The striking observation is that intrachromosomal reciprocal recombination is very rare in comparison with interchromosomal reciprocal recombination. However, intrachromosomal gene conversion occurs at about the same frequency as interchromosomal gene conversion. Reciprocal recombination events between regions on the same chromatid are the most infrequent exchanges. These data suggest that intrachromosomal reciprocal exchanges are suppressed.
The role of vasculature in bone development, regeneration and proper systemic functioning (2017)

Bone is a richly vascularized connective tissue. As the main source of oxygen, nutrients, hormones, neurotransmitters and growth factors delivered to the bone cells, vasculature is indispensable for appropriate bone development, regeneration and remodeling. Bone vasculature also orchestrates the process of hematopoiesis. Blood supply to the skeletal system is provided by the networks of arteries and arterioles, having distinct molecular characteristics and localizations within the bone structures. Blood vessels of the bone develop through the process of angiogenesis, taking place through different, bone-specific mechanisms. Impaired functioning of the bone blood vessels may be associated with the occurrence of some skeletal and systemic diseases, i.e., osteonecrosis, osteoporosis, atherosclerosis or diabetes mellitus. When a disease or trauma-related large bone defects appear, bone grafting or bone tissue engineering-based strategies are required. However, a successful bone regeneration in both approaches largely depends on a proper blood supply. In this paper, we review the most recent data on the functions, molecular characteristics and significance of the bone blood vessels, with a particular emphasis on the role of angiogenesis and blood vessel functioning in bone development and regeneration, as well as the consequences of its impairment in the course of different skeletal and systemic diseases.