gebhart/patrepeval huggingface dataset:
The Role of DNA-PKcs and Artemis in Opening Viral DNA Hairpin Termini in Various Tissues in Mice (2007)

A subset of cellular DNA hairpins at double-strand breaks is processed by DNA-dependent protein kinase catalytic subunit (DNA-PKcs)- and Artemis-associated endonuclease. DNA hairpin termini of adeno-associated virus (AAV) are processed by DNA repair machinery; however, how and what cellular factors are involved in the process remain elusive. Here, we show that DNA-PKcs and Artemis open AAV inverted terminal repeat (ITR) hairpin loops in a tissue-dependent manner. We investigated recombinant AAV (rAAV) genome metabolism in various tissues of DNA-PKcs- or Artemis-proficient or -deficient mice. In the absence of either factor, ITR hairpin opening was impaired, resulting in accumulation of double-stranded linear rAAV genomes capped with covalently closed hairpins at termini. The 5' end of 3-base hairpin loops of the ITR was the primary target for DNA-PKcs- and Artemis-mediated cleavage. In the muscle, heart, and kidney, DNA-PKcs- and Artemis-dependent hairpin opening constituted a significant pathway, while in the liver, undefined alternative pathways effectively processed hairpins. In addition, our study revealed a Holliday junction resolvase-like activity in the liver that cleaved T-shaped ITR hairpin shoulders by making nicks at diametrically opposed sites. Thus, our approach furthers our understanding of not only rAAV biology but also fundamental DNA repair systems in various tissues of living animals.
Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma (2001)

Thioredoxin (Trx) with a redoxactive dithiol together with NADPH and thioredoxin reductase (TrxR) is a major disulfide reductase regulating cellular redox state and cell proliferation and possibly contributing to the drug resistance of malignant cells. We assessed the Trx system in malignant pleural mesothelioma cell lines, in nonmalignant pleural mesothelium and in biopsies of malignant pleural mesothelioma. The mRNA and immunoreactive proteins of Trx and cytosolic and mitochondrial TrxR were positive in all four human mesothelioma cell lines investigated. Six cases of nonmalignant, histologically healthy pleural mesothelium showed no Trx or TrxR immunoreactivity, whereas immunohistochemistry on 26 biopsies of human malignant pleural mesothelioma showed positive Trx in all cases and positive TrxR in 23 (88%) of the cases. Moderate or strong immunoreactivity for Trx or TrxR was detected in 85% (22 cases) and 61% (14 cases) of the mesothelioma cases, respectively. Both Trx and TrxR staining patterns were mainly diffuse and cytoplasmic, but in 39% of the mesothelioma cases prominent nuclear staining could also be detected. Although staining for Trx and TrxR was seen in tumor cells, no significant association could be demonstrated between Trx or TrxR expression and tumor cell proliferation or apoptosis in the biopsies of mesothelioma. There was no significant association between the intensity of Trx or TrxR immunoreactivity and patient survival, which may possibly be related to moderate or intense Trx and TrxR reactivity in most of the cases. Although the Trx system may have an important role in the drug resistance of malignant mesothelioma, these studies also suggest that multiple factors contribute to the promotion, cell proliferation and apoptosis of malignant mesothelioma cells in vivo.
Situation et description des coupes visitées en 1978 (1982)

Weidmann Marc. Situation et description des coupes visitées en 1978. In: Documents des Laboratoires de Géologie, Lyon. Hors-série n°7, 1982. Nouveaux résultats biostratigraphiques dans le bassin molassique, depuis le Vorarlberg jusqu’en Haute-Savoie. Projet P.I.C.G. 73/I/25, section 5. pp. 11-24.
Innovation in the Treatment of Uremia: Proceedings from the Cleveland Clinic Workshop: Uremic Toxicity, Oxidative Stress, and Hemodialysis as Renal Replacement Therapy (2009)

Patients with uremia are subject to greatly increased cardiovascular risk that cannot be completely explained by traditional cardiovascular risk factors. An increase in oxidative stress and inflammation has been proposed as contributory nontraditional uremic cardiovascular risk factors. Oxidative stress reflects the balance between oxidant generation and antioxidant defense mechanisms. Reduction/oxidation (redox) reactions may result in a stochastic process leading to oxidation of neighboring macromolecules. However, in many instances the reactive oxygen species target particular amino acid residues or lipid moieties. This provides a mechanism by which increased oxidative stress and/or alteration of antioxidant mechanisms can alter cell signaling. In individuals with advanced chronic kidney disease, the redox balance is not in equilibrium and is tipped toward oxidation resulting in the dysregulation of cellular process with subsequent vascular and tissue injury. In this review, the major oxidant and antioxidant pathways and the biomarkers to assess redox status in uremia are discussed, as well as the data linking the pathogenesis of oxidative stress, inflammation, cardiovascular events, and the progressive loss of kidney function in chronic kidney disease.
Virtual Disk Reconfiguration with Performance Guarantees in Shared Storage Environment (2005)

In this paper, we present a novel approach of virtual disk reconfiguration with performance guarantee in shared storage environment, which is important for storage maintenance tasks, especially for load balance. It identifies the surplus I/O resource of storage pools after satisfying performance requirement of virtual disks through EPYFQ scheduling algorithms, and gives high priority of using these I/O resources to data migration tasks. Moreover, our approach divides data migration task into multiple storage transactions, which can protect the consistency of the data in reconfigured virtual disks, such that the application I/O and migration I/O can execute concurrently. We also implement our approach into E-DM (Enhanced Device Mapper), a kernel module of Linux, and evaluate it. The result shows that the IOPS of virtual disks is decreased not more than 3% during reconfiguration.
Robust fisher codes for large scale image retrieval (2013)

Fisher vectors (FV) have shown great advantages in large scale visual search. However, traditional FV suffers from noisy local descriptors, which may deteriorate the FV discriminative power. In this paper, we propose a robust Fisher vectors (RFV). To fulfill fast search and light storage over a large scale image dataset, we employ a simple binarization method to compress RFV to generate compact robust Fisher codes (RFC). Extensive comparison experiments on benchmark datasets have shown that both RFV and RFC outperforms the state-of-the-art performance. The scalability of RFC has been validated on a dataset of over 1 million images as well.
The Ubiquitin-like Protein FAT10 Forms Covalent Conjugates and Induces Apoptosis (2001)

FAT10 is a ubiquitin-like protein that is encoded in the major histocompatibility complex class I locus and is synergistically inducible with interferon-gamma and tumor necrosis factor alpha. The molecule consists of two ubiquitin-like domains in tandem arrangement and bears a conserved diglycine motif at its carboxyl terminus commonly used in ubiquitin-like proteins for isopeptide linkage to conjugated proteins. We investigated the function of FAT10 by expressing murine FAT10 in a hemagglutinin-tagged wild type form as well as a diglycine-deficient mutant form in mouse fibroblasts in a tetracycline-repressible manner. FAT10 expression did not affect major histocompatibility complex class I cell surface expression or antigen presentation. However, we found that wild type but not mutant FAT10 caused apoptosis within 24 h of induction in a caspase-dependent manner as indicated by annexin V cell surface staining and DNA fragmentation. Wild type FAT10, but not its diglycine mutant, was covalently conjugated to thus far unidentified proteins, indicating that specific FAT10 activating and conjugating enzymes must be operative in unstimulated fibroblasts. Because FAT10 expression causes apoptosis and is inducible with tumor necrosis factor alpha, it may be functionally involved in the programmed cell death mediated by this cytokine.
A Rate Adaptation Algorithm for Tile-based 360-degree Video Streaming (2017)

In the 360-degree immersive video, a user only views a part of the entire raw video frame based on her viewing direction. However, today's 360-degree video players always fetch the entire panoramic view regardless of users' head movement, leading to significant bandwidth waste that can be potentially avoided. In this paper, we propose a novel adaptive streaming scheme for 360-degree videos. The basic idea is to fetch the invisible portion of a video at the lowest quality based on users' head movement prediction and to adaptively decide the video playback quality for the visible portion based on bandwidth prediction. Doing both in a robust manner requires overcome a series of challenges, such as jointly considering the spatial and temporal domains, tolerating prediction errors, and achieving low complexity. To overcome these challenges, we first define quality of experience (QoE) metrics for adaptive 360-degree video streaming. We then formulate an optimization problem and solve it at a low complexity. The algorithm strategically leverages both future bandwidth and the distribution of users' head positions to determine the quality level of each tile (i.e., a sub-area of a raw frame). We further provide theoretical proof showing that our algorithm achieves optimality under practical assumptions. Numerical results show that our proposed algorithms significantly boost the user QoE by at least 20\% compared to baseline algorithms.
Photothermal reflectance investigation of processed silicon. I. Room-temperature study of the induced damage and of the annealing kinetics of defects in ion-implanted wafers (1990)

Silicon films damaged by ion implantation have been examined using the photothermal reflectance technique in the thermal wave regime (low-modulation frequencies, large laser beam spot sizes). Data are presented on the sensitivity of this method to the implant dose and to the effects of thermal annealing. It has been shown that the technique provides information about the state of the implanted layer, and is a sensitive probe for monitoring the annihilation of the induced damage as a function of the annealing temperature. A model for the kinetics of damage annihilation has been presented to estimate the activation energy of the local annealing recovery mechanism, found to be 0.15 eV. The presence of negative annealing has been detected at about 500 °C, an advantage over the essentially insensitive Hall mobility method.
Phase-conjugating mirror with continuous-wave gain: errata (1981)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Jack Feinberg and R. W. Hellwarth, "Phase-conjugating mirror with continuous-wave gain: errata," Opt. Lett. 6, 257-257 (1981) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
PubChem 2019 update: improved access to chemical data (2018)

PubChem (https://pubchem.ncbi.nlm.nih.gov) is a key chemical information resource for the biomedical research community. Substantial improvements were made in the past few years. New data content was added, including spectral information, scientific articles mentioning chemicals, and information for food and agricultural chemicals. PubChem released new web interfaces, such as PubChem Target View page, Sources page, Bioactivity dyad pages and Patent View page. PubChem also released a major update to PubChem Widgets and introduced a new programmatic access interface, called PUG-View. This paper describes these new developments in PubChem.
Direct determination of trace oxygen in organic materials with an infrared detector after conversion to carbon monoxide (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect determination of trace oxygen in organic materials with an infrared detector after conversion to carbon monoxideI. J. OitaCite this: Anal. Chem. 1984, 56, 7, 1155–1158Publication Date (Print):June 1, 1984Publication History Published online1 May 2002Published inissue 1 June 1984https://pubs.acs.org/doi/10.1021/ac00271a023https://doi.org/10.1021/ac00271a023research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Token scan cell for low power testing (2001)

A multiphase clocking technique is presented for reducing the test power for scan-based circuits. A novel scan cell design called the token scan cell is developed, which combines a phase-generating flip-flop and a data flip-flop to overcome the inter-phase skew and clock routing problems. Experimental results show that on average ~87% of the data transition count during scanning is reduced. For many circuits with long chains, a reduction of >98% can even be achieved.
An Evaluation of Isotonic “Sport Drinks” During Labor (2002)

We compared the metabolic effects of allowing women isotonic “sport drinks” rather than water to drink during labor. The effect of these drinks on gastric residual volume was also evaluated. Sixty women in early labor (cervical dilation <5 cm) were randomized to receive either isotonic sport drinks or water only. Plasma β-hydroxybutyrate, nonesterified fatty acids, and glucose were measured in early labor and at the end of the first stage of labor. Residual gastric volume was assessed within 45 min of delivery by use of an ultrasound scanner. The incidence and volume of vomiting was recorded. At the end of the first stage of labor, plasma β-hydroxybutyrate (P = 0.000) and nonesterified fatty acids (P = 0.000) had increased and plasma glucose (P = 0.007) had decreased significantly in the Water-Only group. Gastric antral cross-sectional area after delivery was similar in the two groups. The incidence of vomiting and the volume vomited during labor and within the hour of delivery were also similar. There was no difference between the groups in any maternal or neonatal outcome of labor. In conclusion, isotonic drinks reduce maternal ketosis in labor without increasing gastric volume.
Reducing the Potential for Heat Stroke to Children in Parked Motor Vehicles: Evaluation of Reminder Technology (2012)

The primary objective of the study was to evaluate products that are designed to prevent children up to 24 months old from being left behind in closed, parked vehicles – a scenario that can result in heat stroke. This preliminary assessment was the first of its kind to evaluate this kind of product. The efficacy of heat stroke prevention technologies in sensing the presence of a child in a child restraint and alerting the caregiver if he or she walks away from the car without removing the child was evaluated. The study also examined the effects of child posture and the time/child movement associated with a typical commute on the efficacy of these devices. It was found that across different evaluations, the devices were inconsistent and unreliable in their performance. They often required adjusting of the position of the child within the child restraint. The distance to activation varied across trials and scenarios, and the devices experienced continual synching/unsynching during use. For some of the devices evaluated, issues such as interference with other electronic devices and inability to function in the presence of liquids were common. In sum, the devices require considerable effort from the parent/caregiver to ensure smooth operation, and often that operation is not consistent.
DNA−CNT Nanowire Networks for DNA Detection (2011)

The ability to detect biological analytes in a rapid, sensitive, operationally simple, and cost-effective manner will impact human health and safety. Hybrid biocatalyzed-carbon nanotube (CNT) nanowire-based detection methods offer a highly sensitive and specific platform for the fabrication of simple and effective conductometric devices. Here, we report a conductivity-based DNA detection method utilizing carbon nanotube-DNA nanowire devices and oligonucleotide-functionalized enzyme probes. Key to our sensor design is a DNA-linked-CNT wire motif, which forms a network of interrupted carbon nanotube wires connecting two electrodes. Sensing occurs at the DNA junctions linking CNTs, followed by amplification using enzymatic metalization leading to a conductimetric response. The DNA analyte detection limit is 10 fM with the ability to discriminate single, double, and triple base pair mismatches. DNA-CNT nanowires and device sensing gaps were characterized by scanning electron microscopy (SEM) and confocal Raman microscopy, supporting the enhanced conductometric response resulting from nanowire metallization.
Self-Healing of Thermoplastics via Living Polymerization (2009)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTSelf-Healing of Thermoplastics via Living PolymerizationHai Ping Wang†, Yan Chao Yuan†, Min Zhi Rong*‡, and Ming Qiu Zhang*‡View Author Information† Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, DSAPM Lab, School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou 510275, P. R. China‡ Materials Science Institute, Zhongshan University, Guangzhou 510275, P. R. China*Corresponding authors: e-mail [email protected] (M.Z.R.), [email protected] (M.Q.Z.); fax +86-20-84036576.Cite this: Macromolecules 2010, 43, 2, 595–598Publication Date (Web):December 29, 2009Publication History Received10 September 2009Revised9 December 2009Published online29 December 2009Published inissue 26 January 2010https://pubs.acs.org/doi/10.1021/ma902021vhttps://doi.org/10.1021/ma902021vrapid-communicationACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views3022Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Monomers,Organic compounds,Polymers,Radical polymerization,Self healing materials Get e-Alerts
Cytogenetic Effect of Some Insecticides in Mouse Spleen (1996)

Several insecticides were tested for their ability to induce chromosomal aberrations in mouse spleen. They were injected i.p. in doses representing approximately 1/8–1/10 of the respective ld50 values. Doses were: DDT, 5.5 mg kg−1 body wt.; malathion, 30 mg kg−1 body wt.; Dursban, 4 mg kg−1 body wt.; Sevin, 7 mg kg−1 body wt.; and Lannate, 1 mg kg−1 body wt. ‘Mitomycin C’ at a dose of 1 mg kg−1 body wt. was used as a positive control. Mice were sacrificed 6, 24 and 48 h after treatment. DDT, malathion, dursban and lannate caused maximum chromosomal aberrations 24 h after injection, whereas Sevin induced its maximum effect 6 h after the treatment. All the insecticides induced statistically significant chromosomal aberrations even after excluding the number of metaphases with gaps. The results indicate genotoxicity in mouse spleen cells.
Apartheid in the Great Outdoors: American Advertising and the Reproduction of a Racialized Outdoor Leisure Identity (2004)

This article provides evidence of a racialized outdoor leisure identity perpetuated in magazine advertisements. The evidence is based on a content analysis of 4000+ advertisements from three magazines (Time, Outside, and Ebony) published between 1984–2000. Advertisements taking place in the Great Outdoors or featuring models participating in wilderness leisure activities rarely include Black models, while advertisements featuring White models regularly make use of Great Outdoors settings and activities. That Black models are confined to urban and suburban environments (within the pages of magazine advertisements), while Whites have exclusive domain over the Great Outdoors, potentially has consequences for how Blacks and Whites perceive wilderness recreation and wilderness spaces.
Validated High-Throughput HPLC Method for the Analysis of Flavonol Aglycones Myricetin, Quercetin, and Kaempferol in Rhus coriaria L. Using a Monolithic Column (2009)

A rapid and simple reversed-phase high-performance liquid chromatographic method using a monolithic column was developed and validated for the separation and quantification of myricetin, quercetin, and kaempferol in Rhus coriaria L. The method employed the isocratic mobile phase acetonitrile-10 mM potassium dihydrogen orthophosphate buffer adjusted to pH 3.0 using orthophosphoric acid (38 + 62, v/v) at a flow rate of 4.0 mL/min; a Chromolith Performance RP-18e (100 x 4.6 mm) monolithic column kept at 40 degrees C; and UV detection at 370 nm. Although the elution order was identical and the selectivity was equivalent, the comparison between monolithic and particulate columns showed that the monolithic column could reduce the separation time to < 1 min without sacrificing column efficiency and selectivity. The method was validated according to International Conference on Harmonization guidelines. The validation characteristics included accuracy, precision, linearity, range, specificity, LOQ, and robustness. The calibration curves were linear (r > 0.999) over the concentration range of 0.88-88.3 micro/mL for myricetin, 0.95-95 microg/mL for quercetin, and 1.43-143.3 microg/mL for kaempferol. The recoveries for all three compounds were above 89%. Myricetin was found to be the major flavonol in the examined plant extracts, followed by minor quantities of quercetin and kaempferol.