gebhart/patrepeval huggingface dataset:
Injury and illness surveillance at local Special Olympic Games. (1990)

The purposes of this study were to: determine the incidence of injury and illness among Special Olympic athletes at local competitions; assess the relative risk of medical problems among Down's syndrome athletes; and compare the relative risk of sports injury incurred by athletes participating in various Special Olympic events. Health stations were set up at all sports venues and injury/illness surveillance records were kept for all injury/illness encounters during a 3-day competition for 777 Special Olympic athletes. A total of 3.5% of the athletes required injury/illness care during the games. Down's syndrome athletes were 3.2 times as likely to encounter a medical problem. Track and field events provided the least activity time and the most injuries. These data suggest that Special Olympic games at the local level are safe and that planners should prepare to treat more illnesses than injuries at such competitions.
Advances and Adventures in Amination Reactions of Olefins and Alkynes (2002)

Recent developments in the area of transition metal-catalyzed amination of olefins and alkynes are reviewed. Special emphasis is given to rhodium-catalyzed oxidative aminations of aromatic olefins.
The 3' untranslated region of alfalfa mosaic virus RNA3 contains a core promoter for minus-strand RNA synthesis and an enhancer element. (1997)

The 3' untranslated regions (UTRs) of the three genomic RNAs of alfalfa mosaic virus consist of a 3' homologous sequence of 145 nt and upstream unique sequences 18-34 nt in length. Mutations were made in the 3' UTR of a cDNA clone of RNA3. Point mutations in five AUGC motifs which interfere with specific binding of coat protein to the 3' UTR had no effect on template activity of RNA3 for minus-strand RNA synthesis in vitro by purified viral RNA-dependent RNA polymerase (RdRp). Deletion analysis showed that the 3' homologous sequence of 145 nt was sufficient for a low level of template activity in the in vitro RdRp assay and a similarly low level of RNA3 accumulation in plants. The presence of an additional sequence of nucleotides 145-165 from the 3' end of RNA3 enhanced template recognition by RdRp in vitro and accumulation of RNA3 in vivo to wild-type levels.
Polymerization‐filled composites prepared with highly active filler‐supported Al/Ti/Mg catalysts. I. Synthesis of homogeneous polyethylene‐based composites (1997)

When it is attached onto the surface of an inorganic filler (kaolin, barite), the (BuO)4Ti/BuMgOct/EtAlCl2/Et3Al system is a highly efficient and very promising catalyst for the production of high-performance polyethylene-based composites. The surface concentration of the hydroxyl groups, the Al/Ti/Mg ratio, and the purity of the reagents have a major effect on the catalyst efficiency and molecular weight, crystallinity, and physico-mechanical properties of the final composite. Under ca. 4 bar partial pressure of ethylene in heptane at 60°C, the optimum Al/Ti/Mg catalyst composition is 120/0.75/10, the efficiency of which is as high as 300 kgPE/(gTi × h) in the presence of kaolin particles (Satintone W/W). The effect of transfer agents, such as hydrogen and 1-octene, and purity of the α-olefin has been investigated. Actually, the catalyst efficiency is increased in the presence of both hydrogen and octene. Scanning Electron Microscopy (SEM) has shown that the ethylene was polymerized from the filler surface. Special attention has also been paid to the effect of size, density, and surface acidity of the filler particles. The surface of basic filler has to be treated in order to become an efficient catalyst carrier. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 64: 423–438, 1997
An Adenovirus Vector Containing the Suicide Gene Thymidine Kinase for a Broad Application in Cancer Gene Therapy (2002)

Treatment of cancer using gene therapy is based on adding a property to the cell leading to its elimination. One possibility is the use of suicide genes that code for enzymes that transform a pro-drug into a cytotoxic product. The most extensively used is the herpes simplex virus thymidine kinase (TK) gene, followed by administration of the antiviral drug ganciclovir (GCV). The choice of the promoter to drive the transcription of a transgene is one of the determinants of a given transfer vector usefulness, as different promoters show different efficiencies depending on the target cell type. In the experiments presented here, we report the construction of a recombinant adenovirus carrying TK gene (Ad-TK) driven by three strong promoters (P CMV IE, SV40 and EN1) and its effectiveness in two cell types. Human HeLa and mouse CCR2 tumor cells were transduced with Ad-TK and efficiently killed after addition of GCV. We could detect two sizes of transcripts of TK gene, one derived from the close together P CMV IE/SV40 promoters and the other from the 1.5 Kb downstream EN1 promoter. The relative amounts of these transcripts were different in each cell type thus indicating a higher flexibility of this system.
CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. (1989)

CL 277,082 (I) was found to be a potent inhibitor of acyl CoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) in microsomes from a variety of tissues with IC50 values of 0.14 microM for intestinal mucosal microsomes, 0.74 microM for liver, and 1.18 microM for rat adrenal. I was also shown to inhibit ACAT in cultured smooth muscle cells (IC50 = 0.8 microM) and was found to be specific in inhibiting cholesterol esterification since it did not inhibit fatty acid incorporation into triglycerides or phospholipids. Also, other cholesterol esterifying enzymes such as lecithin:cholesterol acyltransferase (LCAT) and pancreatic cholesterol esterase were not inhibited by I, nor was esterification of retinol by acyl CoA:retinol acyltransferase (ARAT) from intestinal mucosal microsomes inhibited. I was a potent inhibitor of cholesterol absorption in cholesterol-fed rats by markedly inhibiting increases in liver and serum cholesterol concentration (ED50 = 5.2 mg/kg per day) while increasing the excretion of neutral 14C-labeled sterol in the feces.
Healing of periodontal connective tissues following surgical wounding and application of citric acid in dogs (1980)

Topical application of citric acid to a root surface which has been scaled and root planed results in exposure of collagen fibrils of the dentin matrix. The purpose of this study was to examine the healing of gingival connective tissue adjacent to a root planed and subsequently acid conditioned root surface and to determine whether the exposure of dentin or cementum matrix collagen would facilitate the reestablishment of an attachment between the healing connective tissue and the root surface. Full thickness flaps were raised and labial alveolar bone removed over maxillary incisor roots of seven Labrador retrievers. The exposed root surface was planed before etching with citric acid (pH 1) for 3 min. The flap was then repositioned at its original level. Block sections were obtained after 7, 14, 21 and 42 days and the interface between the root surface and the healing wound tissue studied by light and electron microscopy. Compared to conventional flap surgery in the same animals, application of citric acid to the instrumented root surface resulted in an improved rate of connective tissue healing as well as a rapid and consistent reestablishment of connective tissue attachment through extensive interdigitation of new and old collagen fibrils at the tooth‐gingiva interface. Subsequent reinforcement of the established connective tissue attachment included recalcification of the acid‐affected dentin and deposition of new cementum.
Work-in-progress #1. The lithotriptor and its potential use in the revision of total hip arthroplasty. (1987)

Revision total hip arthroplasty, particularly femoral component replacement, has proved extremely difficult and has met with frequent complications. Despite a variety of devices and techniques that have been developed to facilitate removal of the femoral stem, the procedure remains difficult. Extracorporeal shock wave lithotripsy (ESWL) is a new technique initially created to pulverize renal stones by means of repetitive shock waves delivered to a discrete area. It was felt that perhaps this technique might also be utilized to facilitate the removal of the femoral component and cement from the femoral canal in revision total hip arthroplasty. Using bone cement, cadaveric canine femora were implanted with stainless steel rods placed within the medullary canal. The implanted femora were treated with ESWL, sectioned, and examined, using scanning electron microscopy. Microfracturing of the cement and a disruption of the cement/bone interface were seen in the treated specimens. ESWL has the potential to be used prior to revision total hip arthroplasty to facilitate cement and component removal, although there are several questions that need to be answered prior to considering its clinical use.
Linbots: Soft Modular Robots Utilizing Voice Coils (2018)

Robots performing automated tasks in uncontrolled environments need to adapt to environmental changes. Through building large collectives of robots, this robust and adaptive behavior can emerge from simple individual rules. These collectives can also be reconfigured, allowing for adaption to new tasks. Larger collectives are more robust and more capable, but the size of existing collectives is limited by the cost of individual units. In this article, we present a soft, modular robot that we have explicitly designed for manufacturability: Linbots. Linbots use multifunctional voice coils to actuate linearly, to produce audio output, and to sense touch. When used in collectives, the Linbots can communicate with neighboring Linbots allowing for isolated behavior as well as the propagation of information throughout a collective. We demonstrate that these collectives of Linbots can perform complex tasks in a scalable distributed manner, and we show transport of objects by collective peristalsis and sorting of objects by a two-dimensional array of Linbots.
Mechanism of the reaction of benzyl alcohols with a cyclic trans carbonate (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of the reaction of benzyl alcohols with a cyclic trans carbonateEdward I. Stout, William M. Doane, and Kenneth E. KolbCite this: J. Org. Chem. 1971, 36, 21, 3126–3130Publication Date (Print):October 1, 1971Publication History Published online1 May 2002Published inissue 1 October 1971https://pubs.acs.org/doi/10.1021/jo00820a012https://doi.org/10.1021/jo00820a012research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influence of <i>CYP2D6*5</i> and <i>*10</i> polymorphism on the pharmacokinetics of nebivolol in healthy Chinese subjects (2020)

Both CYP2D6*5 and *10 polymorphism altered the pharmacokinetics of nebivolol in healthy Chinese volunteers. Further studies are required to investigate the effects of these single-nucleotide polymorphisms on the pharmacokinetics, pharmacodynamics and toxicity of nebivolol.
Regression models for ordinal responses: a review of methods and applications (1997)

This paper presents a synthesized review of generalized linear regression models for analysing ordered responses. We recommend that the analyst performs (i) goodness-of-fit tests and an analysis of residuals, (ii) sensitivity analysis by fitting and comparing different models, and (iii) by graphically examining the model assumptions.
The Preparation of Trifluorinated Aldehydes (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of Trifluorinated AldehydesAlbert L. Henne, Ralph L. Pelley, and Robert M. AlmCite this: J. Am. Chem. Soc. 1950, 72, 8, 3370–3371Publication Date (Print):August 1, 1950Publication History Published online1 May 2002Published inissue 1 August 1950https://doi.org/10.1021/ja01164a013RIGHTS & PERMISSIONSArticle Views252Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (282 KB) Get e-Alerts Get e-Alerts
MEDICAL PROBLEMS AND TREATMENT CONSIDERATIONS FOR THE RED IMPORTED FIRE ANT (2002)

DISCLAIMER: This fact sheet provides a review of information gathered regarding medical aspects of the red imported fire ant. As such, this fact sheet is not intended to provide treatment recommendations for fire ant stings or reactions that may develop as a result of a stinging incident. Readers are encouraged to seek health-related advice and recommendations from their medical doctors, allergists or other appropriate specialists.
Design and Characterization of Nanostructure Topical Gel of Betamethasone Dipropionate for Psoriasis (2012)

Md. Sarfaraz Alam*, Md. Sajid Ali, Nawazish Alam, Md Intakhab Alam, Tarique Anwer, Faisal Imam, Md. Daud Ali, Masoom Raza Siddiqui, Md. Shamim College of Pharmacy, Jazan University, Jazan, K.S.A. Department of Pharmacy, Translam Institute of Pharmaceutical Education and Research, Meerut, U.P., India Kinapse India, Gurgaon, Haryana, India Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia, KSA Shivdan Singh Institute of Technology & Management, Aligarh, U.P., India
[Clinical usefulness of the measurement of plasma D-dimer levels]. (1991)

To evaluate the clinical usefulness of D-dimer, various effects on the measurement of D-dimer were examined. Although both fibrinolytic and fibrinogenolytic products were detected by the measurement of FDP, only fibrinolytic products were detected by the measurement of D-dimer. In patients with DIC and other thrombo-embolic diseases, plasma D-dimer levels were significantly higher than in normal persons. A significant positive correlation between plasma D-dimer and serum FDP was found in DIC patients. In patients with DIC associated with acute promyelocytic leukemia, which is thought to be an increased fibrinogenolysis state, serum FDP was higher than the plasma D-dimer which suggests that increased fibrinogenolysis affects the result of serum FDP measurement. Plasma D-dimer significantly increased 5 minutes after endoscopic embolization with thrombin in the patients with esophageal varices. However serum FDP increased 30 minutes after the treatment, which suggests that the D-dimer is more useful for rapid detection of coagulo-fibrinolytic change than serum FDP. Plasma D-dimer was significantly higher in patients with cerebral infarction and increased with age. These finding suggest the usefulness of plasma D-dimer measurement for the specific and rapid evaluation of coagulo-fibrinolytic activation and thrombo-embolic state.
How to Choose a Subset of Frequencies for Frequency-Domain Finite-Difference Migration (2002)

A-38 HOW TO CHOOSE A SUBSET OF FREQUENCIES FOR FREQUENCY-DOMAIN FINITE-DIFFERENCE MIGRATION R.-E. PLESSIX and W.A. MULDER Abstract 1 Frequency-domain finite-difference migration can be accelerated by an order of magnitude if a subset of the available data frequencies is used. To avoid unwanted artefacts the choice of this subset should be guided by two principles: sufficient localisation of reflectors and the avoidance of wrap-around. The first is related to the spatial resolution and Heisenberg’s principle. The second is needed to avoid repetitive patterns and is related to the Nyquist sampling theorem. Here we study both by a simple analytical and
Extract heavy metals via liquid-ion exchange (1980)

Use of the liquid-ion exchange process to elminate heavy metals from wastewater sludge is described. Liquid-ion exchange has been used to recover aluminum from potable water treatment plant sludges. The liquid-ion process is an economically feasible way to remove heavy metals from wastewater sludges. (2 graphs, 8 references, 5 tables)
Nutrient Composition and Metabolizable Energy Values of Selected Grain Sorghum Varieties and Yellow Corn , (1990)

Three low-tannin sorghum grains and one high-tannin variety were grown at the same location in 1985, 1986, 1987, and 1988. The relative CP content of the grains varied among the years. The proteins of sorghum grain contained, on the average, higher concentrations of Ala, Asp, Glu, Leu, Ile, Phe, Tyr, and Val; and lower concentrations of Arg, Gly, and His than did the protein of yellow corn. Both contained similar concentrations of Ser, Lys, Met, Cys, and Thr. An increase in the CP of sorghum grain did not result in a proportional increase in the amino acid content when expressed as a percentage of the CP. Levels of Met, Cys, Lys, Arg, and Thr decreased as a percentage of the CP when CP increased. However, Glu, Asp, Leu, Ile, and Val increased as the CP increased. The ether extract content of yellow corn was 1 to 2% higher than that found in sorghum grain. Ash, Ca, P, and neutral detergent fiber (NDF) levels between the two grains showed minor differences. Sorghum grain contained higher levels of acid detergent fiber (ADF) than did yellow corn. Compared to the low-tannin sorghum, the high-tannin variety contained higher levels of both ADF and NDF. Xanthophyll levels were low in all grain sorghums compared to yellow corn. The MEn content of low-tannin sorghum was not different from yellow corn. However, the MEn of the high-tannin sorghum was lower (P<.05) than yellow com and the low-tannin sorghum varieties.
역T형 옹벽의 지진시 거동특성 (2016)

Permanent deformation plays a key role in performance based earthquake resistant design. In order to estimate permanent deformation after earthquake, it is essential to secure reliable response history analysis(RHA) as well as earthquake scenario. This study focuses on permanent deformation of an inverted T-type wall under earthquake. The study is composed of two separate parts. The first one is on the verification of RHA and the second one is on an effect of input earthquake motion. The former is discussed in companion paper and the latter in this paper. In order to investigate the effect of an input earthquake motion on the permanent deformation, three bins of spectral matched real earthquake records with different magnitude, regions, epicentral distance are constructed. Parametric study was performed using the verified RHA through the companion paper for each earthquake records in the bins. The most influential parameter affecting permanent displacement is magnitude. The other parameters describing earthquake motion are not significant enough to increase permanent displacement of the inverted T-type wall except for energy related parameters(AI, CI, SEI).
Deposition of CTAB-Terminated Nanorods on Bacteria to Form Highly Conducting Hybrid Systems (2005)

Gold nanorods and nanospheres capped with positively charged CTAB are deposited on the surface of gram-positive bacterium having negatively charged teichoic acid brushes. The deposition rate is more than an order of magnitude faster than that for peptide and nucleic acid capped nanoparticles. For the nanorods, never been reported before, the strong electrostatic attraction causes the rods to bend conformally over the curved bacterium surface in random orientations. This leads to formation of an efficient percolating cluster (i.e., low contact resistance and high radius of gyration) with 104-fold higher current at 3-fold lower coverage compared to a monolayer from nanospheres. The high monolayer conductivity at only approximately 10% coverage for nanorods has potential for fabricating a novel class of bioelectronic devices by coupling electronic "nanocircuitry" at the surface to the biological function of microorganisms.
Evaluation of a nitrogen-incorporated tetrahedral amorphous carbon thin film for the detection of tryptophan and tyrosine using flow injection analysis with amperometric detection (2016)

Correction for 'Evaluation of a nitrogen-incorporated tetrahedral amorphous carbon thin film for the detection of tryptophan and tyrosine using flow injection analysis with amperometric detection' by Romana Jarošová, et al., Analyst, 2016, DOI: .
Human <i>ADAM33</i> Messenger RNA Expression Profile and Post-Transcriptional Regulation (2003)

We examined transcript expression and post-transcriptional regulation of human ADAM33, a recently identified asthma gene. A detailed messenger RNA (mRNA) expression profile was obtained using Northern, reverse transcription polymerase chain reaction, and in situ hybridization analyses. ADAM33 mRNA was expressed significantly in smooth muscle-containing organs, minimally in immune organs and hematopoietic cells, and highly in repairing duodenal granulation tissue. Expression was seen in asthmatic subepithelial fibroblasts and smooth muscle but not in respiratory epithelium. In all tissues, transcripts of approximately 5 kb predominated over those of approximately 3.5 kb by 2- to 5-fold. The effect of the 3' untranslated region (UTR) on ADAM33 protein expression and maturation was examined. The presence of the 3'UTR in untagged full-length constructs promoted prodomain removal, detected as mature approximately 100 kD protein by ADAM33-reactive antibodies; in its absence, maturation was 2- to 3-fold less in HEK293 cells. His-tagged and untagged constructs lacking the 3'UTR demonstrated that lack of maturation was not a result of tag-mediated effects. Minimal maturation of ADAM33 occurred in primary lung and MRC5 fibroblasts following adenoviral-mediated expression of ADAM33 lacking the 3'UTR. In contrast, prodomain removal was observed with plasmids and adenovirus encoding only the pro- and catalytic domains. Thus, the 3'UTR of ADAM33 and domains downstream of the catalytic domain regulate potential ADAM33 activity. Mechanisms of regulation of ADAM33, distinct from closely related ADAMs, thus include mRNA localization and processing and protein maturation.