gebhart/patrepeval huggingface dataset:
Functional characterization and cloning of amino acid transporter B<sup>0,+</sup> (ATB<sup>0,+</sup>) in primary cultured rat pneumocytes (2007)

Cationic amino acid transport in primary cultured rat pneumocytes exhibiting characteristics of alveolar epithelial type I-like cells are described. Asymmetry and activator ion dependency of (3)H-L-arginine uptake were characterized from the apical or basolateral fluid of pneumocytes grown on permeable support. Substrate specificity of transport was evaluated as a function of (3)H-L-arginine uptake inhibition in the presence of other amino acids. Transepithelial transport studies estimated (3)H-L-arginine flux in the apical-to-basolateral and basolateral-to-apical directions. Full length cDNA of rat amino acid transporter B(0,+) (rATB(0,+)) was cloned and its relative expression level studied. Results indicate that uptake of (3)H-L-arginine from apical fluid is dependent on Na(+) and Cl(-). Zwitterionic and cationic amino acids (excluding L-proline and anionic amino acids) inhibited uptake of (3)H-L-arginine from apical, but not basolateral incubation fluid. Apical-to-basolateral transepithelial flux of (3)H-L-arginine was 20x higher than basolateral-to-apical transport. Kinetic studies of (3)H-L-arginine uptake from apical fluid revealed maximal velocity (V(max)) and Michaelis-Menten constants (K(t)) of 33.32 +/- 2.12 pmol/mg protein/15 min and 0.50 +/- 0.11 mM, respectively, in a cooperative process having a coupling ratio of 1.18 +/- 0.16 with Na(+) and 1.11 +/- 0.13 with Cl(-). Expression of rATB(0,+) mRNA was identified by RT-PCR and Northern analysis. Corresponding cloned 3.2 kb rATB(0,+) cDNA sequence exhibits pronounced homology in deduced amino acid sequence to mouse (95% identity and 97% similarity) and human (89% identity and 95% similarity) ATB(0,+) homologues. We conclude that rat pneumocytes express ATB(0,+), which may partly contribute towards recovering cationic and neutral amino acids from alveolar luminal fluid.
1 m long continuously-written fibre Bragg gratingsforcombined second- and third-order dispersion compensation (1997)

The authors present the realisation of high-quality 1 m long continuously-written fibre Bragg gratings designed to compensate both second- and third-order fibre dispersion. These compact devices are ideal for counteracting the effects of fibre dispersion in high bit rate transmission systems.
RNAshapes: an integrated RNA analysis package based on abstract shapes (2005)

We introduce RNAshapes, a new software package that integrates three RNA analysis tools based on the abstract shapes approach: the analysis of shape representatives, the calculation of shape probabilities and the consensus shapes approach. This new package is completely reimplemented in C and outruns the original implementations significantly in runtime and memory requirements. Additionally, we added a number of useful features like suboptimal folding with correct dangling energies, structure graph output, shape matching and a sliding window approach.
A transposable element insertion in the susceptibility gene CsaMLO8 results in hypocotyl resistance to powdery mildew in cucumber (2015)

CsaMLO8 was characterised as a functional susceptibility gene to PM, particularly in the hypocotyl where it was transcriptionally upregulated upon inoculation with the PM pathogen P. xanthii. A loss-of-function mutation in CsaMLO8 due to the insertion of a transposable element was found to be the cause of hypocotyl resistance to PM. This particular allele of CsaMLO8 was found to occur in 27 % of the resequenced cucumber accessions.
Conformational Molecular Rectifiers (2004)

Unimolecular rectification based on voltage-controlled intramolecular stereochemical modification is suggested and computationally investigated. In sharp contrast to present molecular rectifiers, these conformational molecular rectifiers (CMRs) differ in principle from silicon structures, deriving their large, strongly temperature-dependent rectification from the differing current pathways in two dominant conformations, controlled by the interelectrode applied field. Two sorts of CMRs, one based on contact modulation the other on bridge modulation, are calculated: an ambient rectification ratio of 102 can be approached.
Protective effect of Morus rubra L. leaf extract on diet-induced atherosclerosis in diabetic rats. (2010)

The antiatherosclerotic effect of aqueous leaves extract of Morus rubra was studied in streptozotocin-induced diabetic rats fed with atherosclerotic (Ath) diet [1.5 ml olive oil containing 8 mg (3, 20,000 IU) vitamin D2 and 40 mg cholesterol] for 5 consecutive days. A short-term toxicity assessment was also conducted in healthy rats to examine toxic effects of the extract. Oral administration of extract to diabetic rats (100, 200 and 400 mg/kg body weight per day for a period of 30 days) produced significant (p<0.001) fall in fasting blood glucose (FBG) in a dose-dependent manner. Treatment with the extract (400 mg/kg) showed significant (p<0.001) improvement in body weight and serum lipid profile i.e., total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and VLDL-cholesterol, when compared with diabetic control. Endothelial dysfunction parameters (sVCAM-1, Fibrinogen, total NO levels and oxidized LDL), apolipoprotein A and apolipoprotein B were significantly (p<0.001) reversed to near normal, following treatment with the extract. Thus, our study shows that aqueous leaf extract of Morus rubra (400 mg/kg) significantly improves the homeostasis of glucose and fat and possesses significant anti-atherosclerotic activity.
Age-dependent deficiency of B lymphocyte lineage precursors in NZB mice. (1982)

Adult NZB mice (greater than 15 wk old) have very few bone marrow cells that can give rise to sIg+ clonable B cells during liquid culture. This deficiency corresponds to extremely low numbers of cells with cytoplasmic but not surface mu chains of IgM and reduced numbers of cells bearing a high molecular weight B-lineage antigen. Depletion of Thy-1-bearing cells and appropriate mixing experiments did not provide evidence either that suppressor cells are responsible for this phenomenon or that accessory cells are defective in NZB mice. Nor did it seem that B cells were being produced in extramedullary sites. B cell precursors were detectable in very young NZB mice, exceeded control values at 4-5 wk of age, and then declined rapidly. In contrast, these persisted for greater than 1 yr in normal BALB/c, DBA/2, and CBA/H mice. It appears possible that intermediate stages in B-lineage differentiation become prematurely exhausted through an accelerated aging process in NZB mice. These chronological changes have implications for understanding the sequence of events that lead to B lymphocyte formation and the processes that normally regulate it.
Factors influencing the outcome of lower‐extremity diabetic ulcers treated with hyperbaric oxygen therapy (2007)

The objectives of this study were to report outcomes of a large number of patients receiving hyperbaric oxygen therapy (HBO(2)T) for diabetic lower-extremity ulcers, and to identify likely outcome predictors. Five hyperbaric facilities supplied data on 1,006 patients. A sixth clinic served as a validation sample for the regression-based prediction model, and later additional data from Memorial Hermann Hospital were added. The severity of lower-extremity lesions was assessed upon initiation of HBO(2)T using the Modified Wagner scale, and the outcome described as healed, partially healed, not improved, amputated, or died. Overall, 73.8% of patients improved (granulated or healed). Factors significantly related to outcome included renal failure, pack-year smoking history, transcutaneous oximetry, number of HBO(2)T treatments, and interruption of treatment regimen. Number of treatments per week and treatment pressure (2.0 vs. 2.4 atmospheres absolute) were not significant factors in outcome. Concomitant administration of autologous growth factor gel did not improve outcome. A multiple regression model was fitted to the data that can be used to predict the outcome of diabetic patients undergoing HBO(2)T. Given the high cost of amputation and rehabilitation, these data suggest that hyperbaric oxygen treatment should be an important adjunctive therapy to heal lower-extremity lesions, especially those with a Wagner grade of 3 or higher.
<i>In vivo</i> pharmacokinetic studies of prodrugs of ibuprofen (2007)

In vivo pharmacokinetic studies of N-Mannich base derivatives of ibuprofenamide as prodrugs were performed on rabbits. Ibuprofen and both the prodrugs (IBMB-M and IBMB-P) were administered orally and at different time intervals blood samples were collected and assayed for ibuprofen and ibuprofenamide by HPLC method. From the plasma concentration-time profile; (C p ) max , t max , AUC and the time required to achieve minimum effective concentration were calculated. N-Mannich base prodrugs first get hydrolyzed to ibuprofenamide which in turn gets hydrolyzed to ibuprofen by the enzyme amidase. The (C p ) max and AUC values of IBMB-M were found to be more compared to IBMB-P. In both the cases ibuprofen started appearing after 2 h and it required minimum 4 h to get the ibuprofen in therapeutic range. Both the prodrugs released ibuprofen slowly which gave sustained effect. IBMB-M provided ibuprofen in therapeutic range for 48 h and IBMB-P for 24 h.
Chemistry of indenothiophenes. II. 4H-indeno[1,2-b]thiophene and 8H-indeno[1,2-c]thiophene (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of indenothiophenes. II. 4H-indeno[1,2-b]thiophene and 8H-indeno[1,2-c]thiopheneD. W. H. MacDowell and Alfred T. JeffriesCite this: J. Org. Chem. 1970, 35, 4, 871–875Publication Date (Print):April 1, 1970Publication History Published online1 May 2002Published inissue 1 April 1970https://pubs.acs.org/doi/10.1021/jo00829a001https://doi.org/10.1021/jo00829a001research-articleACS PublicationsRequest reuse permissionsArticle Views293Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Accelerating Rule-matching Systems with Learned Rankers. (2019)

Infusing machine learning (ML) and deep learning (DL) into modern systems has driven a paradigm shift towards learning-augmented system design. This paper proposes the learned ranker as a system building block, and demonstrates its potential by using rule-matching systems as a concrete scenario. Specifically, checking rules can be time-consuming, especially complex regular expression (regex) conditions. The learned ranker prioritizes rules based on their likelihood of matching a given input. If the matching rule is successfully prioritized as a top candidate, the system effectively achieves early termination. We integrated the learned rule ranker as a component of popular regex matching engines: PCRE, PCRE-JIT, and RE2. Empirical results show that the rule ranker achieves a top-5 classification accuracy at least 96.16%, and reduces the rule-matching system latency by up to 78.81% on a 8-core CPU.
Catalase and alpha-enolase (1998)

Roozendaal, C.1; Zhao, M. H.5; Horst, G.1; Lockwood, C. M.5; Kleibuker, J. H.2; Limburg, P. C.3; Nelis, G. F.4; Kailenberg, C. G.M.1 Author Information
Detection of the intermittent earth faults in compensated MV network (2004)

The experience acquired from the Polish medium voltage power distribution networks shows the unreliability of the localization criterions applied to the intermittent earth faults. It results from the lack of stability and low power level of the measuring signals falling often down below the protection's start-up level. In the paper, a new adaptive algorithm based on the wavelet analysis enabling detection of specific dynamics of the measuring signal during intermittent earth faults is presented. The algorithm was analyzed utilizing the signals generated in the EMTP program package.
Bioceramics: Spark Plasma Sintering (SPS) of Calcium Phosphates (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
MRI‐compatible transurethral ultrasound system for the treatment of localized prostate cancer using rotational control (2008)

Magnetic resonance imaging (MRI)-guided transurethral ultrasound therapy is a potential minimally invasive treatment for localized prostate cancer offering precise targeting of tissue within the gland, short treatment times, and the capability to quantify the spatial heating pattern delivered during therapy. A significant challenge in MRI-guided ultrasound therapy is the design and construction of MRI-compatible equipment capable of operation in a closed-bore MR imager. We describe a prototype system developed for MRI-guided transurethral ultrasound therapy and characterize the performance of the different components including the heating applicator design, rotational motor, and radio frequency electronics. The ultrasound heating applicator described in this study incorporates a planar transducer and is capable of producing high intensity ultrasound energy in a localized region of tissue. Results demonstrated that the heating applicator exhibits excellent MRI-compatibility, enabling precise MR temperature measurements to be acquired as close as 6 mm from the device. Simultaneous imaging and rotational motion was also possible during treatment using a motor based on piezoelectric actuators. Heating experiments performed in both phantoms and in a canine model with the prototype system verified the capability to perform simultaneous MR imaging and therapy delivery with this system. Real-time control over therapy using MR temperature measurements acquired during heating can be implemented to achieve precise patterns of thermal damage within the prostate gland. The technical feasibility of using the system developed in this study for MRI-guided transurethral ultrasound therapy in a closed-bore MR imager has been demonstrated.
Understanding the Recognition of Transfer RNAs by Aminoacyl Transfer RNA Synthetases (1979)

This chapter contains sections titled: Introduction General Characteristics of the Synthetase-tRNA Interaction Determination of Enzyme-tRNA Contact Points Possible Chemical Interactions Between Bound Enzyme and tRNA Future Directions
Population pharmacokinetics and pharmacodynamics of dalfampridine-ER in healthy volunteers and in patients with multiple sclerosis (2012)

The approved therapeutic dosage regimen of dalfampridine-ER 10 mg twice daily was identified as the optimum dosing regimen based on model-predicted exposure response relationships for efficacy and adverse events. A limitation of this study is the limited effectiveness of the models used to predict long-term efficacy and safety of dalfampridine-ER in clinical use.
Effects of different protein diets on growthand food conversion ratio of postlarvae ofMacrobrachium rosenbergii (deMan) (2006)

The experiment was designed to study the effect of different protein levels on the survival and growth of Macrobrachium rosenbergii in nursery phase. The experiment was conducted for 45 days in plastic tubs of 20 L capacity by stocking ten postlarvae weighing 0.015 to 0.018g. Seven diets were formulated at different protein levels of 15, 20, 25, 30, 35, 40 and 45% using the same ingredients. The prawn reared on 40% protein diet exhibited best performance in terms of growth followed by those on 45 and 35% protein diets. However, the high protein efficiency ratio (PER) was recorded in the diet that contained 15% protein.
Electrochemical Sensors for Atmospheric Corrosion Rates: A New Design (1984)

AbstractAbstractA description is given of a modified electrochemical atmospheric corrosion monitor(EACM), having a built-in reference electrode which makes it possible to apply the 3-electrode technique in plotting polarisation curves with thin electrolyte layers, such as those responsible for the atmospheric corrosion phenomenon.In order to determine the possibilities of the new EACM's, some examples are given of their response under laboratory conditions: (1) with 400 μm thick water and Na Cl solution layers, and (2) with invisible adsorbed moisture layers. The EACM's were also tested under natural exposure conditions on CENIM's flat-roof.
Dupilumab facial redness: Positive effect of itraconazole (2019)

Dupilumab, a fully human monoclonal antibody that inhibits interleukin (IL) 4 and IL-13 by blocking the shared IL-4 receptor α and thereby suppressing the T helper type 2–mediated inflammatory response (Th2), is the first biological treatment for moderate to severe atopic dermatitis (AD). We present 2 cases of dupilumab facial redness (DFR), which was not reported in phase 3 clinical trials investigating the efficacy and safety of dupilumab. However, DFR is found to affect approximately 10% of patients treated with dupilumab in daily practice.
An analysis and implementation of step-dynamic voltage regulator (2003)

This paper describes the design considerations and effectiveness of step-dynamic voltage regulator (S-DVR) as a solution to mitigate against voltage sags. A possible short-circuit problem encountered during S-DVR operation is identified and analyzed. Two solutions are proposed and they are validated through computer simulations. A prototype of the S-DVR is then implemented and its effectiveness to compensate for voltage sags is demonstrated.
Automated Optimal Dispatching of Service Requests (2011)

In the services domain, the customers raise issues and service requests in the form of tickets. There is a pool of personnel who work on these tickets and resolve them. The problem at hand is to dispatch these tickets to the most appropriate personnel. Optimality is applied to metrics like the mean service time taken to resolve a ticket, the fair sharing of workload among the personnel, and the size and configuration of the pool. The current state of the art involves a human dispatcher for assigning incoming service requests. Though intelligent, a human dispatcher can be suboptimal with respect to the above mentioned objectives due to the large space of parameter values to be considered. Further, there exists an opportunity to achieve high-level goals such as on-the-job training, eliminating overproduction, and workload balancing among personnel through smarter dispatch decisions. For example, target skill levels of personnel can be achieved by assigning them tickets requiring those skills increasingly. Also, overproduction can be controlled by dispatching only those tickets that otherwise would be in the danger of missing deadline (SLO) constraints. Our work involves the design and implementation of an automated dispatcher which would take various characteristics of the tickets and the pool state as input and recommend an intelligent dispatching decision for the tickets, based on the above-mentioned goals and constraints.
Sulfonation with Sulfur Trioxide - High Boiling Alkylated Benzene (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfonation with Sulfur Trioxide - High Boiling Alkylated BenzeneEverett Gilbert and Benjamin VeldhuisCite this: Ind. Eng. Chem. 1958, 50, 7, 997–1000Publication Date (Print):July 1, 1958Publication History Published online1 May 2002Published inissue 1 July 1958https://pubs.acs.org/doi/10.1021/ie50583a025https://doi.org/10.1021/ie50583a025research-articleACS PublicationsRequest reuse permissionsArticle Views165Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Nucleocytoplasmic transport of mRNA (1996)

The movement of mRNA from the nucleus to the cytoplasm is one of the crucial checkpoints in the regulation of gene expression. However, the molecular mechanism of RNA transport is largely unknown. The aim of this thesis is to investigate some of the rules that govern this process.^ The first part of the thesis is focused on how the process of splicing affects mRNA export. The specific questions asked were whether the process of splicing promotes the export of mRNA from the nucleus, or whether removal of splice sites is actually required. The mouse polyoma virus was used as a model system to approach these issues. Results led to the proposal that the process of splicing in the polyoma system is not necessary for mRNA export, nor does it make export more efficient. Instead, removal of splicing machinery from mRNA may be required for export.^ The second part of the thesis was to learn how naturally intronless gene transcripts are transported from the nucleus to the cytoplasm and to determine whether these transcripts contain positive cis-acting transport elements. By using a variety of approaches, a novel cis-acting transport element, called HTE, contained within the mouse histone H2a gene coding region was identified. This element facilitates the cytoplasmic accumulation of intronless gene transcripts and of unspliced HIV-1-related mRNAs. HTE is the first example of cellular element that has such functions.^ The last part of the thesis was to determine the role of polyadenylation in mRNA nuclear export. By exploiting a cis-acting ribozyme that uncouples 3$\\sp\\prime$ end formation from the cellular polyadenylation machinery, evidence that polyadenylation is a prerequisite for mRNA nuclear export and that a long stretch of poly(A) near the 3$\\sp\\prime$ end of an mRNA is not sufficient for mRNA export was obtained. ^