gebhart/patrepeval huggingface dataset:
Continuous Flow Cell Washing System (1968)

Advancements in blood therapy during the past decade have indicated the need for a presterilized disposable cell washing system. Experimental and prototype developments indicate the feasibility of continuous washing for 1) removal of plasma protein from red cell masses, 2) deglycerolization of frozen red cells, 3) removal of cellular debris, and 4) separation of mixed cell populations. A new system has been designed to accomplish these separations. Initial studies indicate a thousandfold concentration reduction of initial supernate per liter of wash solution per unit of blood. Studies using isotopes and rates of dye removal formed the basis of further studies of programs utilizing deglycerolization and density gradient separation of cells. The basis for the development of the system and experimental results obtained from this system are defined.
Amidine−Oximes: Reactivators for Organophosphate Exposure (2011)

A new class of amidine-oxime reactivators of organophosphate (OP)-inhibited cholinesterases (ChE) were designed, synthesized, and tested. These compounds represent a novel group of oximes with enhanced capabilities of crossing the blood-brain barrier. Lack of brain penetration is a major limitation for currently used oximes as antidotes of OP poisoning. The concept described herein relies on a combination of an amidine residue and oxime functionality whereby the amidine increases the binding affinity to the ChE and the oxime is responsible for reactivation. Amidine-oximes were tested in vitro and reactivation rates for OP-BuChE were greater than pralidoxime (2-PAM) or monoisonitrosoacetone (MINA). Amidine-oxime reactivation rates for OP-AChE were lower compared to 2-PAM but greater compared with MINA. After pretreatment for 30 min with oximes 15c and 15d (145 μmol/kg, ip) mice were challenged with a soman model compound. In addition, 15d was tested in a post-treatment experiment (145 μmol/kg, ip, administration 5 min after sarin model compound exposure). In both cases, amidine-oximes afforded 100% 24 h survival in an animal model of OP exposure.
Out‐of‐core compression and decompression of large <i>n</i>‐dimensional scalar fields (2003)

Abstract We present a simple method for compressing very large and regularly sampled scalar fields. Our method is particularlyattractive when the entire data set does not fit in memory and when the sampling rate is high relative to thefeature size of the scalar field in all dimensions. Although we report results for and data sets, the proposedapproach may be applied to higher dimensions. The method is based on the new Lorenzo predictor, introducedhere, which estimates the value of the scalar field at each sample from the values at processed neighbors. The predictedvalues are exact when the n‐dimensional scalar field is an implicit polynomial of degree n − 1 . Surprisingly,when the residuals (differences between the actual and predicted values) are encoded using arithmetic coding,the proposed method often outperforms wavelet compression in an L ∞ sense. The proposed approach may beused both for lossy and lossless compression and is well suited for out‐of‐core compression and decompression,because a trivial implementation, which sweeps through the data set reading it once, requires maintaining only asmall buffer in core memory, whose size barely exceeds a single ( n −1)‐ dimensional slice of the data. Categories and Subject Descriptors (according to ACM CCS): I.3.5 [Computer Graphics]: Compression, scalar fields,out‐of‐core.
Advanced Group Treatment for Developmentally Disabled Adults with Social Skill Deficits (2000)

Objective This social work research evaluates the effectiveness of an advanced, experimental treatment program for improving social skills with 6 developmentally disabled adults in a vocational training project. Method The effectiveness of the group treatment program was evaluated using multiple baseline designs replicated for 6 participants across six social skills. The intervention was developed in a previous study, and the skills were selected using a needs assessment. Results Results were mixed, and treatment gains from baseline to treatment phases were inconsistent across skills and participants. A 1-year follow-up assessment revealed that posttreatment skill levels were usually maintained. Conclusions These results only partially support the effectiveness of the group treatment program. Possible explanations for this conclusion are given, and clinical implications for social workers are discussed.
Staphylococcus aureus Biofilm and Planktonic cultures differentially impact gene expression, mapk phosphorylation, and cytokine production in human keratinocytes (2011)

Collectively the results indicate that S. aureus biofilms induce a distinct inflammatory response compared to their planktonic counterparts. The differential gene expression and production of inflammatory cytokines by biofilm and planktonic cultures in keratinocytes could have implications for the formation and persistence of chronic wounds. The formation of a biofilm should be considered in any study investigating host response to bacteria.
N-terminal brain natriuretic peptide predicted cardiovascular events stronger than high-sensitivity C-reactive protein in hypertension: a LIFE substudy (2006)

Nt-proBNP predicted a composite endpoint after adjustment for traditional risk factors, UACR and a history of diabetes or cardiovascular disease and added significantly to the prediction of composite endpoint, whereas hsCRP did not.
Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: parallels with <i>Drosophila</i> sense-organ development (1998)

The sensory patches in the vertebrate inner ear are similar in function to the mechanosensory bristles of a fly, and consist of a similar set of cell types. If they are truly homologous structures, they should also develop by similar mechanisms. We examine the genesis of the neurons, hair cells and supporting cells that form the sensory patches in the inner ear of the chick. These all arise from the otic epithelium, and are produced normally even in otic epithelium cultured in isolation, confirming that their production is governed by mechanisms intrinsic to the epithelium. First, the neuronal sublineage becomes separate from the epithelial: between E2 and E3.5, neuroblasts delaminate from the otocyst. The neuroblasts then give rise to a mixture of neurons and neuroblasts, while the sensory epithelial cells diversify to form a mixture of hair cells and supporting cells. The epithelial patches where this occurs are marked from an early stage by uniform and maintained expression of the Notch ligand Serrate1. The Notch ligand Delta1 is also expressed, but transiently and in scattered cells: it is seen both early, during neuroblast segregation, where it appears to be in the nascent neuroblasts, and again later, in the ganglion and in differentiating sensory patches, where it appears to be in the nascent hair cells, disappearing as they mature. Delta-Notch-mediated lateral inhibition may thus act at each developmental branchpoint to drive neighbouring cells along different developmental pathways. Our findings indicate that the sensory patches of the vertebrate inner ear and the sensory bristles of a fly are generated by minor variations of the same basic developmental program, in which cell diversification driven by Delta-Notch and/or Serrate-Notch signalling plays a central part.
Contention Window Adjustment for IEEE 802.11 WLANs: A Control-Theoretic Approach (2006)

IEEE 802.11 is currently the most popular standard for Wireless LANs. The Distributed Coordination Function (DCF) defines the primary medium access control of 802.11, which uses the CSMA/CA mechanism and Binary Exponential Backoff (BEB) for Contention Window (CW) adjustment when collisions occur. In this paper, we propose a new CW adjustment scheme, CW Idle-Slots-based Control (WISC), using a control-theoretic approach. Specifically, we design and implement a PD (Proportional and Derivative) controller at each contending station, that dynamically adjusts CW based on a locally available channel state, i.e., the average number of consecutive idle slots between two transmissions, such that the channel state converges to the optimal value. Simulation results demonstrate that the new scheme outperforms the standard BEB in terms of both throughput and fairness, especially at high contention levels.
Retroviral Vector-Modified Bone Marrow Stromal Cells Secrete Biologically Active Factor IX <i>In Vitro</i> and Transiently Deliver Therapeutic Levels of Human Factor IX to the Plasma of Dogs after Reinfusion (1998)

Canine bone marrow stromal cells (BMSCs), transduced ex vivo with retroviral vectors, expressed and secreted biologically active human and canine coagulation factor IX (hFIX and cFIX) in vitro, and on autologous reinfusion expressed hFIX into the circulation of normal (nonhemophiliac) dogs. Human FIX, when expressed in vitro by BMSCs of two dogs at 1.22 and 1.39 microg/10(6) cells/24 hr in medium supplemented with vitamin K, respectively, exhibited 28.1 and 27.3% normal biological activity as determined on the basis of a one-stage clotting assay. BMSCs of two additional dogs expressed 1.54 and 4.81 microg of cFIX/10(6) cells/24 hr in vitamin K-supplemented medium and the expressed cFIX possessed 58.4 and 32.9% normal activity, respectively. Between 2.33 and 3.35 x 10(8) transduced BMSCs, expressing 1.22 and 2.61 microg of hFIX/10(6) cells/24 hr or 3.24 and 7.82 microg of cFIX/10(6) cells/24 hr were reintroduced into the four donor dogs by intravenous infusion. Human FIX was detected in plasma for 7 or 12 days after BMSC reinfusion, with peak levels of 85.8 and 233.0 ng/ml observed at 2 days. Canine anti-hFIX antibodies, which were detected as early as 2-4 days after reinfusion of BMSCs expressing hFIX, may have masked potentially longer duration expression in vivo. Peak plasma levels of hFIX represented 2.1 and 5.8% normal human hFIX levels. When adjusted for percent normal one-stage clotting activity determined in vitro, these levels represented 0.6 and 1.6% normal human hFIX activity levels. Thus, we have demonstrated that retroviral vector-modified BMSCs can deliver human therapeutic levels of hFIX to the circulation of dogs.
High-Performance Liquid Chromatography-Mass Spectrometry of Glycosphingolipids: I. Structural Characterization of Molecular Species of GlcCer and IV3βGal-Gb4Cer1 (1989)

A method of high-performance liquid chromatography-fast atom bombardment mass spectrometry (HPLC/FAB/MS) for the structural characterization of glycosphingolipids was developed, which involves a frit interface between the HPLC and the MS. The molecular species of glucosylceramide (GlcCer) purified from the spleen of a patient with Gaucher's disease and galactosylglobotetraosylceramide (IV3 beta Gal-Gb4Cer) from mouse kidney were analyzed using this system on a reversed-phase column, with methanol containing 1% glycerol as the elution solvent. The injection of 1 microgram of GlcCer gave the mass spectra of seven major molecular species, the pseudo-molecular ion for each of the seven molecular species being observed at m/z 698, 726, 754, 782, 808, 796, and 810, respectively. The injection of 200 pg of synthetic N-stearoyl glucosylsphingosine (d18:1) gave a clear peak with the single ion monitoring method detecting the pseudo-molecular ion at m/z 726. The injection of 5 micrograms of IV3 beta Gal-Gb4Cer gave the mass spectra of six major molecular species, the pseudo-molecular ions being observed at m/z 1,489, 1,471, 1,515, 1,497, 1,517, and 1,499. This report deals with a new HPLC/FAB/MS system, which was successfully applied to the structural characterization of the molecular species of neutral glycosphingolipids, and the system is a quite promising for development into a quantitative method for glycosphingolipids with high sensitivity and specificity.
Scaling quantum-dot light-emitting diodes to submicrometer sizes (2002)

We introduce a device structure and a fabrication technique that allow the realization of efficient light-emitting diodes (LEDs) with dimensions of the active area in the ≈100 nm range. Using optical lithography, selective oxidation, and an active region consisting of InAs quantum dots (QDs), we fabricated LEDs with light–current–voltage characteristics which scale well with nominal device area down to 600 nm diam at room temperature. The scaling behavior provides evidence for strong carrier confinement in the QDs and shows the potential for the realization of high-efficiency single-photon LEDs operating at room temperature.
Soybean-Oil-Based Waterborne Polyurethane Dispersions: Effects of Polyol Functionality and Hard Segment Content on Properties (2008)

The environmentally friendly vegetable-oil-based waterborne polyurethane dispersions with very promising properties have been successfully synthesized without difficulty from a series of methoxylated soybean oil polyols (MSOLs) with different hydroxyl functionalities ranging from 2.4 to as high as 4.0. The resulting soybean-oil-based waterborne polyurethane (SPU) dispersions exhibit a uniform particle size, which increases from about 12 to 130 nm diameter with an increase in the OH functionality of the MSOL from 2.4 to 4.0 and decreases with increasing content of the hard segments. The structure and thermophysical and mechanical properties of the resulting SPU films, which contain 50-60 wt % MSOL as renewable resources, have been studied by Fourier transform infrared spectroscopy, differential scanning calorimetry, dynamic mechanical analysis, thermogravimetric analysis, transmission electron microscopy, and mechanical testing. The experimental results reveal that the functionality of the MSOLs and the hard segment content play a key role in controlling the structure and the thermophysical and mechanical properties of the SPU films. These novel films exhibit tensile stress-strain behavior ranging from elastomeric polymers to rigid plastics and possess Young's moduli ranging from 8 to 720 MPa, ultimate tensile strengths ranging from 4.2 to 21.5 MPa, and percent elongation at break values ranging from 16 to 280%. This work has addressed concerns regarding gelation and higher cross-linking caused by the high functionality of vegetable-oil-based polyols. This article reports novel environmentally friendly biobased SPU materials with promising applications as decorative and protective coatings.
The Utility of Clustering in Prediction Tasks (2015)

We explore the utility of clustering in reducing error in various prediction tasks. Previous work has hinted at the improvement in prediction accuracy attributed to clustering algorithms if used to pre-process the data. In this work we more deeply investigate the direct utility of using clustering to improve prediction accuracy and provide explanations for why this may be so. We look at a number of datasets, run k-means at different scales and for each scale we train predictors. This produces k sets of predictions. These predictions are then combined by a naïve ensemble. We observed that this use of a predictor in conjunction with clustering improved the prediction accuracy in most datasets. We believe this indicates the predictive utility of exploiting structure in the data and the data compression handed over by clustering. We also found that using this method improves upon the prediction of even a Random Forests predictor which suggests this method is providing a novel, and useful source of variance in the prediction process.
Snap happy! (2018)

Photos are a great resource for one-to-one time and group discussion. Make them a focus for discussing holiday destinations, memories and expectations, drawing on their own experiences.
Biosurfactant-Facilitated Remediation of Metal-Contaminated Soils (1995)

Raina M. Miller, Biosurfactant-Facilitated Remediation of Metal-Contaminated Soils, Environmental Health Perspectives, Vol. 103, Supplement 1: Fate, Transport, and Interactions of Metals (Feb., 1995), pp. 59-62
The use of Liquid Membranes in the Multi‐Resdue Extraction of Stilbenes in a Variety of Biological Matrices and Their Detection with LC‐ES‐MS (2006)

Supported liquid membrane (SLM) has been used as a sample preparation method in the simultaneous extraction of a mixture of three stilbene compounds in cow's milk, urine, bovine kidney and liver tissues matrices. The stilbene compounds analysed included, dienestrol, diethylstilbestrol and hexestrol. The liquid membrane used for trapping these compounds consisted of 5% tri-n-octylphosphine oxide (TOPO) dissolved in di-n-hexylether/n-undecane (1:1). The extraction efficiencies obtained after enrichment of 1 ng/L stilbenes in variety of biological matrices of milk, urine, liver, kidney and water, ranged from 60 - 70%, 71 - 86%, 69 - 80%, 63 - 7A% and 72 - 93% respectively. The detection limits obtained from urine extraction were 2.1 ng/L, 1.3 ng/L and 3.0 ng/L; from liver and kidney tissues were 2.9 ng/L, 1.6 ng/L and 3.8 ng/L and from milk was 3.2 ng/L, 2.5 ng/L and 4.3 ng/L for hexestrol, dienestrol and diethylstilbestrol respectively.
Dynamic properties of quantum dot distributed feedback lasers (2004)

Semiconductor quantum dots (QDs) are nano-structures with three-dimensional spatial confinement of electrons and holes, representing the ultimate case of the application of the size quantization concept to semiconductor hetero-structures. The knowledge about the dynamic properties of QD semiconductor diode lasers is essential to improve the device performance and understand the physics of the QDs. In this dissertation, the dynamic properties of QD distributed feedback lasers (DFBs) are studied. The response function of QD DFBs under external modulation is characterized and the gain compression with photon density is identified to be the limiting factor of the modulation bandwidth. The enhancement of the gain compression by the gain saturation with the carrier density in QDs is analyzed for the first time with suggestions to improve the high speed performance of the devices by increasing the maximum gain of the QD medium. The linewidth of the QD DFBs are found to be more than one order of magnitude narrower than that of conventional quantum well (QW) DFBs at comparable output powers. The figure of merit for the narrow linewidth is identified by the comparison
Direct Seeding in Reforestation – A Field Performance Review (2017)

Direct seeding has been considered a forest restoration option for centuries. Over the past half century, the use of this practice has declined in developed countries as forest regeneration programs have advanced with the production of quality seedlings that can successfully establish restoration sites. Direct seeding is being reconsidered as a restoration option as the potential size of the worldwide forest restoration program has grown because of massive deforestation in third-world nations and due to global climate change. This review examines direct seeding from a number of perspectives. First, merits of using this practice in restoration programs are defined. Major merits of this option are that it can be done quickly, over hard to reach and large disturbed areas, and at a relatively low cost. Second, current research findings from restoration programs are discussed. The major finding is that seedling establishment rates are low (i.e. typically around 20% of seeds planted) due to site conditions, seed predation and vegetation competition, and field performance (i.e. survival and growth) is lower than planted seedlings. Third, operational practices for the application in restoration programs are reviewed. To successfully conduct direct seeding programs practitioners need to consider seedbed receptivity, seed distribution and seeding rate. Fourth, potential new practices are presented. Some of these new practices attempt to create a more effective means to disperse seed across the site, minimize seed predation or create a more favorable microsite environment. This review provides a synthesis of what is known about direct seeding, thereby allowing practitioners to make a rational decision of whether to apply this practice towards their forest restoration program.
Cerebroelectrical Depression Following Surfactant Treatment in Preterm Neonates (1992)

During surfactant treatment of respiratory distress syndrome, 23 premature newborns were investigated with continuous amplitude-integrated electroencephalography (cerebral function monitors). Simultaneously, arterial blood pressure and transcutaneous blood gas values were recorded. A short (less than 10 minutes) but significant decrease in cerebral activity was seen in almost all neonates immediately after the surfactant instillation, in spite of an improved pulmonary function. In 21 of 23 neonates, a transient fall in mean arterial blood pressure of 9.3 mm Hg (mean) occurred coincidently with the cerebral reaction. Neonates in whom intraventricular hemorrhage developed tended to have lower presurfactant mean arterial blood pressure (P greater than .05), but they had a significantly lower mean arterial blood pressure after surfactant instillation (P less than .05). No other differences were found between neonates in whom intraventricular hemorrhage developed and those without intraventricular hemorrhage. The present findings demonstrate that an acute cerebral dysfunction may occur after surfactant instillation. In some vulnerable neonates with arterial hypotension and severe pulmonary immaturity, the fall in mean arterial blood pressure may increase the risk of cerebral complications and could be related to an unchanged rate of intraventricular hemorrhage after surfactant treatment.
Improved methods of detection of meningococcal DNA from oropharyngeal swabs from cases and contacts of meningococcal disease (2000)

In the UK the increasing use of pre-admission parenteral antibiotic therapy in meningococcal disease has lessened the value of routine cultures as a tool to confirm diagnosis, and laboratory confirmation of invasive meningococcal infection is achieved increasingly by non-culture, nucleic acid amplification methods. The purpose of this study was to evaluate a DNA extraction and meningococcal-specific DNA amplification methodology for detection of meningococci from oropharyngeal swabs. One hundred and six swabs from suspected or confirmed cases of meningococcal disease, and 94 swabs from contacts of meningococcal disease cases were examined. Of laboratory-confirmed cases, 38/65 (58.5%) yielded a positive oropharyngeal swab PCR result and 5/24 (20.8%) swabs from suspected but laboratory-unconfirmed cases were PCR positive. No significant differences in PCR positivity rates were found between the types of swab transport systems utilized, but transport time to the testing laboratory was found to affect PCR positivity (P < 0.05). Application of meningococcus-specific PCR to oropharyngeal swabs, in addition to routine culture of swabs, can provide valuable epidemiological information as well as case confirmation for contact management. PCR amplification of meningococcal PCR from oropharyngeal swabs will also increase the ascertainment in swabbing surveys carried out as part of meningococcal disease outbreak investigation and management.
Models for Sale (2009)

Imagine walking into your favorite traditional brick and mortar store. It may be a book store, a retail clothing outlet, or perhaps even a music shop that sells CDs. You know what to expect when you walk in the door; you probably plan to turn and go right to one particular section that has the goods you want to peruse. But, imagine that when you first enter the store, you notice something very askew: all of the shelves are empty. There are no products anywhere in sight.KeywordsView FunctionPage TitleShopping CartPython CodeCategory PageThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Laboratory Fume Hoods: A User's Manual (1993)

Road Map. Room Air Patterns. Basic Hood Design. Applied Product Design. Face Velocity. Systems Design. Discipline. Qualitative Testing. Quantitative Testing. Specifications. Glossary. Index.