gebhart/patrepeval huggingface dataset:
Chemotherapy of Parasitic Worms: New Biochemical Strategies (1979)

Many chemotherapeutic agents that are effective against parasitic helminths affect cellular regulatory sites that control motility, metabolism, chemotaxis, and egg formation. Serotonin receptors are present in several species of parasitic flatworms and appear to participate in the regulation of motility and carbohydrate metabolism. In Fasciola hepatica these receptors are coupled to an adenylate cyclase through a cellular component that requires guanosine triphosphate. Serotonin is the most potent indoleamine agonist, while lysergic acid diethylamide and its 2-bromo derivative are the most potent antagonists. These studies are revealing additional sites in trematodes that may be important for the development of new and more selective chemotherapeutic agents.
Genome-wide characterization of methylguanosine-capped and polyadenylated small RNAs in the rice blast fungus Magnaporthe oryzae (2010)

Small RNAs are well described in higher eukaryotes such as mammals and plants; however, knowledge in simple eukaryotes such as filamentous fungi is limited. In this study, we discovered and characterized methylguanosine-capped and polyadenylated small RNAs (CPA-sRNAs) by using differential RNA selection, full-length cDNA cloning and 454 transcriptome sequencing of the rice blast fungus Magnaporthe oryzae. This fungus causes blast, a devastating disease on rice, the principle food staple for over half the world's population. CPA-sRNAs mapped primarily to the transcription initiation and termination sites of protein-coding genes and were positively correlated with gene expression, particularly for highly expressed genes including those encoding ribosomal proteins. Numerous CPA-sRNAs also mapped to rRNAs, tRNAs, snRNAs, transposable elements and intergenic regions. Many other 454 sequence reads could not be mapped to the genome; however, inspection revealed evidence for non-template additions and chimeric sequences. CPA-sRNAs were independently confirmed using a high affinity variant of eIF-4E to capture 5'-methylguanosine-capped RNA followed by 3'-RACE sequencing. These results expand the repertoire of small RNAs in filamentous fungi.
Investigating the Feasibility of Utilizing Carbon Nanotube Fibers for Spacesuit Dust Mitigation (2016)

United States
Acoustic Signatures in the Cosmic Microwave Background (1996)

We study the uniqueness and robustness of acoustic signatures in the cosmic microwave background by allowing for the possibility that they are generated by some as yet unknown source of gravitational perturbations. The acoustic {\it pattern} of peak locations and relative heights predicted by the standard inflationary cold dark matter model is essentially unique and its confirmation would have deep implications for the causal structure of the early universe. A generic pattern for isocurvature initial conditions arises due to backreaction effects but is not robust to exotic source behavior inside the horizon. If present, the acoustic pattern contains unambiguous information on the curvature of the universe even in the general case. By classifying the behavior of the unknown source, we determine the minimal observations necessary for robust constraints on the curvature. The diffusion damping scale provides an entirely model independent cornerstone upon which to build such a measurement. The peak spacing, if regular, supplies a precision test.
A high-speed low-power Hi-CMOS 4K static RAM (1979)

A high-speed low-power CMOS fully static, 4096 word by 1 bit random-access memory (RAM) has been developed, which contains a bipolar-CMOS (BCMOS) circuit on the same chip. The device is realized using low-power-oriented circuit design and high-performance CMOS technology utilizing 3-µm gate length. The fabricated 4K static RAM has an address access time of 43 ns and a power dissipation of 80 mW.
Fast and High Resolution 3D Face Scanning (2007)

In this work, we present a framework to capture 3D models of faces in high resolutions with low computational load. The system captures only two pictures of the face, one illuminated with a colored stripe pattern and one with regular white light. The former is needed for the depth calculation, the latter is used as texture. Having these two images a combination of specialized algorithms is applied to generate a 3D model. The results are shown in different views: simple surface, wire grid respective polygon mesh or textured 3D surface.
HC-Search: A Learning Framework for Search-based Structured Prediction (2014)

Structured prediction is the problem of learning a function that maps structured inputs to structured outputs. Prototypical examples of structured prediction include part-of-speech tagging and semantic segmentation of images. Inspired by the recent successes of search-based structured prediction, we introduce a new framework for structured prediction called HC-Search. Given a structured input, the framework uses a search procedure guided by a learned heuristic H to uncover high quality candidate outputs and then employs a separate learned cost function C to select a final prediction among those outputs. The overall loss of this prediction architecture decomposes into the loss due to H not leading to high quality outputs, and the loss due to C not selecting the best among the generated outputs. Guided by this decomposition, we minimize the overall loss in a greedy stage-wise manner by first training H to quickly uncover high quality outputs via imitation learning, and then training C to correctly rank the outputs generated via H according to their true losses. Importantly, this training procedure is sensitive to the particular loss function of interest and the time-bound allowed for predictions. Experiments on several benchmark domains show that our approach significantly outperforms several state-of-the-art methods.
How do centralized and distributed version control systems impact software changes? (2014)

Distributed Version Control Systems (DVCS) have seen an increase in popularity relative to traditional Centralized Version Control Systems (CVCS). Yet we know little on whether developers are benefitting from the extra power of DVCS. Without such knowledge, researchers, developers, tool builders, and team managers are in the danger of making wrong assumptions.
Design and implementation of non-photorealistic rendering techniques for 3D geospatial data (2016)

Geospatial data has become a natural part of a growing number of information systems and services in the economy, society, and people's personal lives. In particular, virtual 3D city and landscape models constitute valuable information sources within a wide variety of applications such as urban planning, navigation, tourist information, and disaster management. Today, these models are often visualized in detail to provide realistic imagery. However, a photorealistic rendering does not automatically lead to high image quality, with respect to an effective information transfer, which requires important or prioritized information to be interactively highlighted in a context-dependent manner.

Approaches in non-photorealistic renderings particularly consider a user's task and camera perspective when attempting optimal expression, recognition, and communication of important or prioritized information. However, the design and implementation of non-photorealistic rendering techniques for 3D geospatial data pose a number of challenges, especially when inherently complex geometry, appearance, and thematic data must be processed interactively. Hence, a promising technical foundation is established by the programmable and parallel computing architecture of graphics processing units.

This thesis proposes non-photorealistic rendering techniques that enable both the computation and selection of the abstraction level of 3D geospatial model contents according to user interaction and dynamically changing thematic information. To achieve this goal, the techniques integrate with hardware-accelerated rendering pipelines using shader technologies of graphics processing units for real-time image synthesis. The techniques employ principles of artistic rendering, cartographic generalization, and 3D semiotics—unlike photorealistic rendering—to synthesize illustrative renditions of geospatial feature type entities such as water surfaces, buildings, and infrastructure networks. In addition, this thesis contributes a generic system that enables to integrate different graphic styles—photorealistic and non-photorealistic—and provide their seamless transition according to user tasks, camera view, and image resolution.

Evaluations of the proposed techniques have demonstrated their significance to the field of geospatial information visualization including topics such as spatial perception, cognition, and mapping. In addition, the applications in illustrative and focus+context visualization have reflected their potential impact on optimizing the information transfer regarding factors such as cognitive load, integration of non-realistic information, visualization of uncertainty, and visualization on small displays.
SV40‐adenovirus immortalized cell lines derived from mouse lymphoid dendritic cell preparations (1995)

Dendritic cells (DC) are antigen-presenting cells characteristic in their rarity and potent ability to stimulate resting T cells. We established several cell lines from purified mouse spleen DC and Langerhans' cells (LC) by infecting them with recombinant SV40ori(-)-adenovirus. Using this method, cells from these fractions are efficiently transformed at a frequency as high as 5 x 10(-6). Some established lines have dendritic morphology, express surface markers specific for DC (defined by mAb 33D1 and NLDC145) and weak substrate adherence. Interestingly, these lines simultaneously express B cell markers (B220 and Ly-1) and/or macrophage markers (Mac-1 and F4/80). Among the lines, OT6.2 and OT8.3.1 have retained stimulating activity in mixed lymphocyte reactions (MLR) which is attributable to the primary T cell stimulating activity of native DC. However, these lines also present soluble antigens to T cell clones, a secondary T cell stimulating activity, characteristic of B cells and macrophages. Although transformation has perturbed the functional discreteness of the DC cell lineage, DC-specific properties are partially preserved in the cell lines. These cell lines may provide useful experimental systems for the elucidation of molecular mechanisms involved in the MLR and the differentiation of DC.
Further Studies of β-Eliminations Involving Silicon<sup>1</sup> (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFurther Studies of β-Eliminations Involving Silicon1Leo H. Sommer, Donald L. Bailey, and Frank C. WhitmoreCite this: J. Am. Chem. Soc. 1948, 70, 9, 2869–2872Publication Date (Print):September 1, 1948Publication History Published online1 May 2002Published inissue 1 September 1948https://pubs.acs.org/doi/10.1021/ja01189a009https://doi.org/10.1021/ja01189a009research-articleACS PublicationsRequest reuse permissionsArticle Views150Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High concentrations of adrenergic antagonists prolong sciatic nerve blockade by tetrodotoxin (2001)

High concentrations of adrenergic antagonists markedly prolonged TTX block, but not bupivacaine block. This locally mediated action does not appear to be adrenergic-receptor-specific, or mediated by GTPase activation.
A verification technique for gated clock (1993)

Article Free Access Share on A verification technique for gated clock Authors: Masamichi Kawarabayashi View Profile , Narendra Shenoy View Profile , Alberto Sangiovanni-Vincentelli View Profile Authors Info & Claims DAC '93: Proceedings of the 30th international Design Automation ConferenceJuly 1993 Pages 123–127https://doi.org/10.1145/157485.164624Published:01 July 1993Publication History 1citation287DownloadsMetricsTotal Citations1Total Downloads287Last 12 Months4Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Characterization of Transgenic Pigs That Express Human Decay Accelerating Factor and Cell Membrane‐tethered Human Tissue Factor Pathway Inhibitor (2010)

The expression of human complement regulatory proteins (hCRP; hDAF, hCD59, and hMCP) in pig tissues has been suggested as one of strategies to overcome the hyperacute rejection (HAR) in pig-to-human transplantation. Expression of human tissue factor pathway inhibitor (hTFPI) in porcine endothelial cells has been suggested as a remedy to overcome microvascular thrombosis. To investigate the effects of these combined transgenes, we established transformed pig cells expressing human decay accelerating factor (hDAF) under the control of enhancer promoter (5'LTR-PCMVIE), and the fusion protein (hTFPI/hCD4) consisting of the functional domains (K1 and K2) of hTFPI and membrane-tethering domains (D3 and D4) of hCD4 under the control of PCMVIE. Transgenic pigs were generated with the transformed porcine cells through somatic cell nuclear transfer (SCNT) technology. Analysis of quantitative PCR and real-time quantitative RT-PCR showed that four copies of hDAF were integrated and 391 copies of hDAF mRNA expressed in the cells of the transgenic pig. The enhancing activity of 5'LTR was approximately 2 fold compared to CMVIE promoter only. The cell viability test showed that more than 80% of ear cells were viable in the presence of 50% human serum. The chromogenic substrate assay and immunocytochemical staining with tail cells showed that the TFPI activity of fusion protein was observed on the cell membrane. The membrane localization of hDAF and hTFPI proteins was observed by immunocytochemical staining, and the expression of transgenes in heart and liver tissues was also confirmed by immunohistochemistry.
Monitoring water uptake of polyurethanes by <i>in situ</i> fluorescence technique (2001)

Abstract The water uptake of three polyurethane adhesives was studied by an in situ fluorescence method applying extrinsic fluorescent probes. The measurements were made in water immersion at 50 and 80°C, and in water vapor at 50°C. An intensity ratio method was applied, in which ratios of the highest and lowest intensity changes in the fluorescence emission bands were used to determine the amount of water sorbed in the polymer films. The ratio method was used to compare the fluorescence data with those obtained by a conventional gravimetric method. Comparable results were obtained. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 82: 1593–1599, 2001
The Inheritance of Aliphatic Glucosinolates in <i>Brassica napus</i> (1993)

Abstract The inheritance of aliphatic glucosinolates was studied in crosses between synthetic B. napus lines and oilseed rape cultivars. Six unlinked loci are described which determine the aliphatic glucosinolate profile of B. napus. One locus regulates the presence or absence of propyl glucosinolates, while another regulates the expression of pentyl glucosinolates. Two loci regulate the removal of the terminal H 3 CS‐group from the amino acid derivative to produce alkenyl glucosinolates as opposed to methylthioalkyl and methylsulphinylalkyl glucosinolates, regardless of the length of the alkyl chain. Likewise, another two loci regulate the hydroxylation of both butenyl and pentenyl glucosinolates. The functional alleles at one of the hydroxylation loci results in significantly more hydroxylation than those at the other locus. The large number of aliphatic glucosinolates which have been described in Brassica thus results from an interaction between genes which regulate side chain elongation and genes which modify the structure of the side chain, regardless of its length. The implications of this study for the biosynthesis of aliphatic glucosinolates, the origin of B. napus and the potential to manipulate the leaf and seed glucosinolate profile of oilseed rape are discussed.
Porting legacy interpretive bytecode to the CLR (2002)

We describe and evaluate five different approaches to executing legacy BCPL programs on the Common Language Runtime. The approaches cover the entire spectrum of machine-independent compilation, from high-level source code to low-level bytecode. We discuss the trade-offs involved with each approach.
Acetyl Coenzyme A Stimulates RNA Polymerase II Transcription and Promoter Binding by Transcription Factor IID in the Absence of Histones (2000)

Protein acetylation has emerged as a means of controlling levels of mRNA synthesis in eukaryotic cells. Here we report that acetyl coenzyme A (acetyl-CoA) stimulates RNA polymerase II transcription in vitro in the absence of histones. The effect of acetyl-CoA on basal and activated transcription was studied in a human RNA polymerase II transcription system reconstituted from recombinant and highly purified transcription factors. Both basal and activated transcription were stimulated by the addition of acetyl-CoA to transcription reaction mixtures. By varying the concentrations of general transcription factors in the reaction mixtures, we found that acetyl-CoA decreased the concentration of TFIID required to observe transcription. Electrophoretic mobility shift assays and DNase I footprinting revealed that acetyl-CoA increased the affinity of the general transcription factor TFIID for promoter DNA in a TBP-associated factor (TAF)-dependent manner. Interestingly, acetyl-CoA also caused a conformational change in the TFIID-TFIIA-promoter complex as assessed by DNase I footprinting. These results show that acetyl-CoA alters the DNA binding activity of TFIID and indicate that this biologically important cofactor functions at multiple levels to control gene expression.
OBSERVATIONS ON THE BEHAVIOR OF HYDROGEN IN ZIRCONIUM (1953)

Abstract: "Some embrittling effects noted in Zr have been explained by the presence of hydrogen. This phenomenon was initially correlated with the existence of a second phase in the microstructure. The amount of this phase is reduced by vacuum annealing and shows a direct correlation with the hydrogen content of the specimen. X-ray and electron-diffraction evidence identifies the phase as ZrH. Observations are given on the solubilities, diffusion rates and equilibrium pressures of hydrogen in zirconium, and the application of these data to the removal of hydrogen."
Frontal Lobe Function and Dysfunction (1991)

Abstract The cognitive and behavioral functions of the frontal lobes have been of great interest to neuroscientists, neurologists, psychologists and psychiatrists. Recent technical advances have made it possible to trace their neuroanatomical connections more precisely and to conduct evoked potential and neuroimaging studies in patients. This book presents a broad and authoritative synthesis of research progress in this field. It encompasses neuroanatomical studies; experiments involving temporal organization and working memory tasks in non-human primates; clinical studies of patients following frontal lobe excisions for intractable epilepsy; metabolic imaging in schizophrenia and affective disorder; neurobehavioral studies of patients with dementia, frontal lobe tumors, and head injuries; magnetic resonance imaging methods for studying human frontal lobe anatomy; theoretical approaches to describing frontal lobe functions; and rehabilitation of patients with frontal lobe damage including their core problem of diminished awareness. Written by a distinguished group of neuroscientists, psychologists and clinicians, Frontal Lobe Function and Dysfunction provides the best current source of information on this region of the brain and its role in cognition, behavior and clinical disorders.
A Dichotomy for Regular Expression Membership Testing (2017)

We study regular expression membership testing: Given a regular expression of size m and a string of size n, decide whether the string is in the language described by the regular expression. Its classic O(nm) algorithm is one of the big success stories of the 70s, which allowed pattern matching to develop into the standard tool that it is today. Many special cases of pattern matching have been studied that can be solved faster than in quadratic time. However, a systematic study of tractable cases was made possible only recently, with the first conditional lower bounds reported by Backurs and Indyk [FOCS'16]. Restricted to any “type” of homogeneous regular expressions of depth 2 or 3, they either presented a near-linear time algorithm or a quadratic conditional lower bound, with one exception known as the Word Break problem. In this paper we complete their work as follows: (1) We present two almost-linear time algorithms that generalize all known almost-linear time algorithms for special cases of regular expression membership testing. (2) We classify all types, except for the Word Break problem, into almost-linear time or quadratic time assuming the Strong Exponential Time Hypothesis. This extends the classification from depth 2 and 3 to any constant depth. (3) For the Word Break problem we give an improved Õ(nm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/3</sup> + m) algorithm. Surprisingly, we also prove a matching conditional lower bound for combinatorial algorithms. This establishes Word Break as the only intermediate problem. In total, we prove matching upper and lower bounds for any type of bounded-depth homogeneous regular expressions, which yields a full dichotomy for regular expression membership testing.
Disparity between skin perfusion and sublingual microcirculatory alterations in severe sepsis and septic shock: a prospective observational study (2008)

During the early phase of resuscitated severe sepsis and septic shock there appears to be no correlation between sublingual microcirculatory alterations and the central-to-toe temperature difference. This finding adds to the concept of a dispersive nature of blood flow under conditions of sepsis between microcirculatory and systemic hemodynamics.
Alkali Flame Detector for Organic Nitrogen Compounds (1969)

A GC detector using an alkali salt modified hydrogen/air flame is described which has high sensitivity to nitrogen-containing organic molecules and simultaneously a 1000-fold lower sensitivity to hydrocarbons. The operating parameters that have been investigated with respect to optimum performance are detector geometry and construction, electrode spacing, electrode configuration, flame gas composition and flow stability of flame gases. Demonstration of applicability is shown with the analyses of crude oil, steroids and amino acids.