gebhart/patrepeval huggingface dataset:
KLRG1+ NK Cells Protect T-bet–Deficient Mice from Pulmonary Metastatic Colorectal Carcinoma (2014)

We studied the developmental and functional mechanisms behind NK cell-mediated antitumor responses against metastatic colorectal carcinoma (CRC) in mice. In particular, we focused on investigating the significance of T-box transcription factors and the immunotherapeutic relevance of IL-15 in the development and function of tumor-reactive NK cells. Pulmonary CRC metastases were experimentally seeded via an adoptive i.v. transfer of luciferase-expressing CT26 CRC cells that form viewable masses via an in vivo imaging device; genetically deficient mice were used to dissect the antitumor effects of developmentally different NK cell subsets. IL-15 precomplexed to IL-15 receptor-α was used in immunotherapy experiments. We found that mice deficient for the T-box transcription factor T-bet lack terminally differentiated antitumor CD27(low)KLRG1(+) NK cells, leading to a terminal course of rapid-onset pulmonary CRC metastases. The importance of this NK cell subset for effective antitumor immunity was shown by adoptively transferring purified CD27(low)KLRG1(+) NK cells into T-bet-deficient mice and, thereby, restoring immunity against lung metastasis formation. Importantly, immunity to metastasis formation could also be restored in T-bet-deficient recipients by treating mice with IL-15 precomplexed to IL-15 receptor-α, which induced the development of eomesodermin(+)KLRG1(+) NK cells from existing NK cell populations. Thus, contingent upon their T-bet-dependent development and activation status, NK cells can control metastatic CRC in mice, which is highly relevant for the development of immunotherapeutic approaches in the clinic.
Gabbard's Treatments of Psychiatric Disorders. Fourth Edition (2008)

The Journal of Nervous and Mental Disease: March 2008 - Volume 196 - Issue 3 - p 260 doi: 10.1097/NMD.0b013e318167372b
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. (1994)

Germ-line mutations in the human adenomatous polyposis coli (APC) gene result in familial adenomatous polyposis, an autosomal dominant disorder characterized by the early onset of multiple adenomatous polyps in the large bowel with a high likelihood of developing colorectal carcinomas. To understand the role of APC in intestinal tumor formation, we have introduced a chain-termination mutation in the 15th exon of the mouse Apc gene and employed it to modify the endogenous gene by homologous recombination in embryonic stem cells. Mice which are heterozygous for the Apc gene modification progressively develop intestinal tumors in a manner that is similar to that observed in patients with familial adenomatous polyposis and in mice which carry a mutation called multiple intestinal neoplasia (Min). Our results indicate that the Apc gene modification is a critical event in the initiation of intestinal tumor formation and results in an autosomal dominant predisposition toward development of spontaneous colonic and intestinal tumors in mice.
Acid‐sensing ion channel (ASIC) 1a undergoes a height transition in response to acidification (2010)

The acid-sensing ion channel (ASIC) 1a is known to assemble as a homotrimer. Here, we used atomic force microscopy to image ASIC1a, integrated into lipid bilayers, at pH 7.0 and pH 6.0. The triangular appearance of the channel was clearly visible. A height distribution for the channels at pH 7.0 had two peaks, at 2 and 4 nm, likely representing the intracellular and extracellular domains, respectively. At pH 6.0 the 2-nm peak remained, but the higher peak shifted to 6 nm. Hence, the extracellular domain of the channel becomes 'taller' after acidification.
High precision electrical substitution radiometer based on superconducting-resistive-transition edge thermometry (1998)

We describe the design and measured electrical performance of the first electrical substitution radiometer based on superconducting thermometers. Prospective applications emphasize high precision measurement of low power, mid- and far-IR blackbody radiation. The minimum noise floor for a single measurement of substitution power was 2 pW for an integration time of 2.7 s. For an extended series of experiments covering a range of substitution power from 0.5 nW to 5 μW, the noise floor can be roughly approximated as 4 pW plus 7×10−6 times the measured power. Analysis of the results indicates the precision is limited by a combination of thermal parasitics and electronic noise contributions.
Optical parametric oscillator with non-ideal mirrors and single- and multi-mode pump beams (1999)

Residual re ections of the idler wave in nominally singly resonant optical parametric oscillators can lead to uctuations in the output because the parametric conversion process is sensitive to the phases of the re ected waves. The energy fluctuations in a pulsed optical parametric oscillator are studied experimentally and numerically for single- or multi-longitudinal mode pump beams. We find that the fluctuations are reduced by a multi-mode pump so this may be preferable when unwanted re ections are present. We also observe that the parametric conversion process leads to serious self-focusing of the pump beam, and this limits the maximum safe pump energy.
Thermogenesis in human skeletal muscle as measured by direct microcalorimetry and muscle contractile performance during <i>β</i>-adrenoceptor blockade (1986)

1. The influence of β-adrenoceptor-blockade on skeletal muscle was studied in ten healthy males with propranolol, atenolol and pindolol randomly given for 8 days each in a cross-over double blind test. After 7 days on each drug, muscle function was tested by an isokinetic dynamometer. Thermogenesis in biopsy samples taken from vastus lateralis muscle after a low grade exercise was studied after 8 days on each drug by direct calorimetry with a perfusion microcalorimeter. 2. Before drug administration, a median heat production rate of 0.67 mW/g of muscle was measured. This value was significantly reduced by 25% during propranolol, but no significant change was found during atenolol or pindolol administration. 3. Peak torque decline during isokinetic endurance test changed significantly in knee flexor but not in extensor muscles, from 15% to 27% after propranolol and from 15% to 23% after pindolol. Maximum dynamic strength was unaltered. 4. Our data suggest that blockade of sympathetic β2-receptors decreases thermogenesis in human skeletal muscle and impairs isokinetic endurance.
CORRIGENDUM. DISCUSSION. THE CONSTRUCTION OF THE MERSEY TUNNEL. (1939)

Keywords CONSTRUCTION, TUNNELS, MERSEY TUNNEL MORPETH DOCK, GEORGES DOCK, MERSEY TUNNEL UK... Show All
Upper-Limb Powered Exoskeleton Design (2007)

An exoskeleton is an external structural mechanism with joints and links corresponding to those of the human body. With applications in rehabilitation medicine and virtual reality simulation, exoskeletons offer benefits for both disabled and healthy populations. A pilot database defining the kinematics and dynamics of the upper limb during daily living activities was one among several factors guiding the development of an anthropomorphic, 7-DOF, powered arm exoskeleton. Additional design inputs include anatomical and physiological considerations, workspace analyses, and upper limb joint ranges of motion. The database was compiled from 19 arm activities of daily living. The cable-actuated dexterous exoskeleton for neurorehabilitation (CADEN)-7 offers remarkable opportunities as a versatile human-machine interface and as a new generation of assistive technology. Proximal placement of motors and distal placement of cable-pulley reductions were incorporated into the design, leading to low inertia, high-stiffness links, and backdrivable transmissions with zero backlash. The design enables full glenohumeral, elbow, and wrist joint functionality. Potential applications of the exoskeleton as a wearable robot include: 1) a therapeutic and diagnostics device for physiotherapy, 2) an assistive (orthotic) device for human power amplifications, 3) a haptic device in virtual reality simulation, and 4) a master device for teleoperation.
COMPARISON OF PHYSICAL PROPERTIES OF THREE SILKS (1994)

Orb-web weaving spiders synthesize and use a variety of silks, each having different propertie s suited to their particular functions . Three of these silks were collected from two different species of spiders an d subjected to physical/mechanical testing . The major ampullate (dragline), minor ampullate, and cocoon silks o f both Nephila clavipes and Araneus gemmoides were load tested on an Instron Universal test frame to compar e their physical properties . The single fibers of major, minor, and cocoon silk of Nephila appear to be more elastic than that of Araneus . Araneus silks, on the other hand, appear to be stronger, requiring a higher stress to brea k the fiber than that of Nephila .
Multidisciplinary management of gastric cancer (2010)

The therapeutic mode has changed over time, although surgery remains the main treatment of choice for gastric cancer. Surgery alone provides long-term survival in only 30% of patients with advanced stages because of the high risk of recurrence and metastasis. Multimodal strategies including neoadjuvant and (or) adjuvant protocols combined with surgery have significantly improved the prognosis of patients with gastric cancer. In particular, perioperative chemotherapy has become the new standard for treatment of patients with advanced gastric cancer. Adjuvant therapy should be carefully discussed after surgical resection, mainly in patients with large lymph node-positive tumors when neoadjuvant therapy can not be carried out. This article reviews the relevant literature on the multidisciplinary management of gastric cancer, and discusses strategies to improve the efficacy of locoregional failures.

Key words: 
Gastric neoplasms;  Multidisciplinary; Diagnosis;  Therapy
Personalizing relevance on the Semantic Web through trusted recommendations from a social network (2006)

Personalization efforts to date have centred on presenting web users with novel items by predicting what they may find relevant. This approach has utility where the user is unsure of exactly what they are looking for, but not where they have a particular information need to satisfy or a particular item to locate. Furthermore, by operating purely on a predefined database of users and items, systems using this approach represent closed worlds and offer poor scalability to new data sets. To address these limitations we propose a technique for personalizing relevance in information seeking activities, based on an understanding of how people seek information and recommendations from their social network. We then describe technical work in progress, based on Semantic Web technologies, that aims to realize this perspective.
The Canonical Complex Structure of Flag Manifolds in a C*-algebra (1998)

The final objective of this article is to study the space of increasing n-tuples of self-adjoint idempotents in a C*-algebra—which is called a flag manifold—from a differential geometric point of view. It is proved that a flag manifold has a natural intrinsic complex structure. Some properties of this structure are examined and a generalization of the well-known Gram-Schmidt construction is considered.
Measurements of Thermal Neutron Cross Section and Resonance Integral for 237Np(n,.GAMMA.)238Np Reaction. (1994)

Making use of a standard neutron spectrum field with a pure Maxwellian distribution, the thermal neutron cross section for the 237Np(n, γ)238Np reaction was measured at a neutron energy of 0.0253 eV by the activation method. The result is 158±3 b, which is obtained relative to the reference value of 98.65±0.09 b for the 197Au(n, γ)198Au reaction. Although the data in JENDL-3 is larger by about 15% than the present value, the recently revised data in JENDL-3.2 is close to the present. The ENDF/B-V, ENDF/B-VI, JEF-2 and Mughabghab's data are also larger by 7–15%. Old measurements are larger by 7–18% than the present data.
Herpes simplex virus type 1 DNA replication and gene expression during explant-induced reactivation of latently infected murine sensory ganglia (1994)

Infectious virus assays and PCR amplification of DNA and RNA were used to investigate herpes simplex virus DNA replication and gene expression in two murine in vitro models for virus reactivation. We examined latent infections with wild-type (wt), precisely defined latency-associated transcript-negative (LAT-) mutants, and LAT+ rescuants of these mutants of the 17syn+ strain of virus in both murine trigeminal and lumbosacral ganglia and of the KOS(M) strain in the latter. In explants of ganglia latently infected with the LAT- mutant of strain 17syn+ virus, a reduction in number of cultures exhibiting cytopathic effects due to virus reactivation and measurable delays in virus recovery were observed compared with wt or the LAT+ rescuant. This LAT-specific effect was not seen in explants of lumbosacral ganglia latently infected with mutants derived from the KOS(M) strain of virus. Although there was appreciable variation between individual animals, no significant difference between LAT+ and LAT- virus in time of onset of viral DNA replication in explanted ganglia was seen with use of either virus strain. There was a slight decrease in the relative amount of viral DNA recovered compared with internal cellular controls in latently infected ganglia harboring the LAT- mutant of 17syn+ compared with the wt virus or the LAT+ rescuant. This reduced relative amount ranged from 0 to as much as 50% but averaged 20%. Such differences were not seen in infections with KOS(M)-derived mutants. In contrast, although expression of productive-cycle transcripts could be detected within 4 h following explant cultivation of latently infected ganglia, no differences between LAT+ and LAT- viruses could be seen. As discussed, these data place specific constraints on possible models for the role of LAT expression in in vitro reactivation systems.
The Mechanism of Corrosion Inhibition and Transition to Underdeposit Corrosion (1987)

Abstract Corrosion inhibition of carbon steel by 2-phosphono-butane-l,2,4-tricarboxylic acid is based on the formation of an inhibiting film. Changes in the water composition in contact with this film during formation influence its growth rate and thickness. The initial state of the steel surface is also important in film formation. Certain chemical parameters create conditions where the film grows to a greater thickness, resembling scale formation. This disturbed film is then a good model for underdeposit corrosion mechanism studies. Surface methods (ESCA, Auger spectroscopy, and SEM) have been used to investigate the structure and composition of this transitional film.
Shadow Penumbras for Complex Objects by Depth-Dependent Filtering of Multi-Layer Depth Images (1999)

This paper presents an efficient algorithm for filtering multi-layer depth images (MDIs) in order to produce approximate penumbras. The filtering is performed on a MDI that represents the view from the light source. The algorithm is based upon both ray tracing and the z-buffer shadow algorithm, and is closely related to convolution methods. The methods effectiveness is demonstrated on especially complex objects such as trees, whose soft shadows are expensive to compute by other methods. The method specifically addresses the problem of light-leaking that occurs when tracing rays through discrete representations, and the inability of convolution methods to produce accurate self-shadowing effects.
Object manifold learning with action features for active tactile object recognition (2014)

In this paper, we consider an object recognition problem based on tactile information using a robot hand. The robot performs an exploratory action to the object to obtain the tactile information, however, poorly designed actions may not be sufficiently informative. In contrast, if we could collect sample data by sequentially performing informative actions, i.e., active learning, the required time would be drastically reduced. To this end, we propose a novel approach for active tactile object recognition. Our approach combines both an active learning scheme and a nonlinear dimensionality reduction method. We first extracts the object manifold, each coordinate of which represents an object, from tactile sensor data and action features using Gaussian Process Latent Variable Models. At the same time, a probabilistic model of the observed data related to the action and the object are learned. Then, with the learned model, optimally-informative exploratory actions can be computed sequentially, and performed to efficiently collect the data for recognition. We show experimental results that verify the effectiveness of our proposed method with synthetic data and a real robot.
Immersive VR for natural interaction with a haptic interface for Shape Rendering (2015)

This paper presents an immersive virtual reality system that includes a natural interaction approach based on free hand gestures that is used to drive a Desktop Haptic Strip for Shape Rendering (DHSSR). The DHSSR is a mechatronic display of virtual curves intersecting 3D virtual objects, and aims at allowing designers to evaluate the quality of shapes during the conceptual design phase of new products. The DHSSR consists of a 6DOF servo-actuated developable metallic strip, which reproduces cross-sectional curves of 3D virtual objects. Virtual curves can be interactively generated on the 3D surface of the virtual object, and coherently the DHSSR haptic interface renders them. An intuitive and natural modality for interacting with the 3D virtual objects and 3D curves is offered to users, who are mainly industrial designers. This consists of an immersive virtual reality system for the visualization of the 3D virtual models and a hand gestural interaction approach used by the user for handling the models. The system has been implemented by using low cost and open technologies, and combines a software engine for interactive 3D content generation (Unity 3D), the Oculus Rift Head Mounted Display for 3D stereo visualization, a motion capture sensor (LeapMotion) for tracking the user's hands, and the Arduino Leonardo board for controlling the components. Results reported in the paper are positive for what concerns the quality of the rendering of the surface, and of the interaction modality proposed.
Novel Models of Myxoid Liposarcoma Xenografts Mimicking the Biological and Pharmacologic Features of Human Tumors (2010)

This study reports for the first time the characterization of human myxoid liposarcoma xenografts that adequately mimic the biological and pharmacologic features of the human tumor. These models offer a useful tool for investigating the mechanism of selectivity of trabectedin, testing new combinations with this drug and evaluating novel therapies for myxoid liposarcoma.
An intranet-based formulary management system (2000)

Journal Article An intranet-based formulary management system Get access M. Craig Barrett, Pharm.D., M. Craig Barrett, Pharm.D. Pharmacist Department of Pharmacy, Baylor University Medical Center, Dallas, TX 97014 Search for other works by this author on: Oxford Academic Google Scholar Michelle M. Megellas, Pharm.D., Michelle M. Megellas, Pharm.D. Formulary/DUE Coordinator Department of Pharmacy, Baylor University Medical Center, Dallas, TX 97014 Search for other works by this author on: Oxford Academic Google Scholar Marilyn Keenan-Milligan, M.S., Marilyn Keenan-Milligan, M.S. Director of Pharmacy Department of Pharmacy, Baylor University Medical Center, Dallas, TX 97014 Search for other works by this author on: Oxford Academic Google Scholar Tracy S. Aber, Pharm.D., BCPS Tracy S. Aber, Pharm.D., BCPS Associate Director of Clinical Services Department of Pharmacy, Baylor University Medical Center, Dallas, TX 97014 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 57, Issue 9, 1 May 2000, Pages 907–908, https://doi.org/10.1093/ajhp/57.9.907 Published: 01 May 2000
Rendering algorithms for deterministic fractals (1995)

Heavy computation requirements have inhibited the application of fractal technology, but new algorithms for coding and displaying iterated function system fractals are achieving real-time performance in software. We discuss the standard rendering algorithms and introduce a variation that performs a minimal number of arithmetic operations when constructing an approximate fractal. In addition, we describe novel extensions that let us render gray-scale and color fractal images.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Glycogen Storage Disease Type II: Identification of Four Novel Missense Mutations (D645N, G648S, R672W, R672Q) and Two Insertions/Deletions in the Acid α-Glucosidase Locus of Patients of Differing Phenotype (1998)

Glycogen storage disease type II (GSDII), an autosomal recessive myopathic disorder, results from deficiency of lysosomal acid α-glucosidase. We searched for mutations in an evolutionarily conserved region in 54 patients of differing phenotype. Four novel mutations (D645N, G448S, R672W, and R672Q) and a previously described mutation (C647W) were identified in five patients and their deleterious effect on enzyme expression demonstratedin vitro.Two novel frameshifting insertions/deletions (Δnt766-785/insC and +insG@nt2243) were identified in two patients with exon 14 mutations. The remaining three patients were either homozygous for their mutations (D645N/D645 and C647W/C647W) or carried a previously described leaky splice site mutation (IVS1 −13T→G). For all patients “in vivo” enzyme activity was consistent with clinical phenotype. Agreement of genotype with phenotype andin vitroversusin vivoenzyme was seen in three patients (two infantile patients carrying C647W/C647W and D645N/+insG@nt2243 and an adult patient heteroallelic for G648S/IVS1 −13T→G). Relative discordance was found in a juvenile patient homozygous for the non-expressing R672Q and an adult patient heterozygous for the minimally expressing R672W and Δnt766-785/+insC. Possible explanations include differences inin vitroassays vsin vivoenzyme activity, tissue specific expression with diminished enzyme expression/stability in fibroblasts vs muscle, somatic mosaicism, and modifying genes.
O visível e o enunciável no dispositivo pedagógico da mídia: contribuição do pensamento de Foucault aos estudos de comunicação (2010)

At this work, I discuss the contribution of Michel Foucault to the investigations that articulate the communication and education areas. The objective here is to problematize Foucault notions of knowing, power and subjectiveness, extending the communication studies, since the "apparatus" concept; more specifically: what we have denominated, in the recent researches of "pedagogical apparatus of media", since then. There is a supposition that Foucault´s work has suggested a possible methodological proposal, which we can realize the visible and enunciable from texts, sounds and images of media, in a way to articulate discoursive practices and non-discoursive practices related to certain "symptoms" of contemporary culture, which are subjects at media.
Clinical evaluation of serum concentrations of intercellular adhesion molecule-1 in patients with colorectal cancer (2005)

In this study, serum ICAM-1 levels were found to be related to tumor presence, clinical stages, and grade. Increased ICAM-1 in patients with colorectal cancer which should be considered when the diagnostic and/or prognostic usefulness of soluble ICAM-1 is to be evaluated. sICAM-1 should prove useful for monitoring malignant disease stage and for evaluating the effectiveness of various therapeutic approaches for colorectal carcinomas.