gebhart/patrepeval huggingface dataset:
Tyrosine hydroxylase: a substrate of cyclic AMP-dependent protein kinase. (1980)

Data demonstrating the direct phosphorylation of tyrosine hydroxylase [tyrosine 3-monooxygenase; L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] purified from rat pheochromocytoma by ATP, Mg2+ and cyclic AMP-dependent protein kinase catalytic subunit are presented. The incorporation of phosphate is highly correlated with the activation of the hydroxylase when either the time of preincubation or the amount of protein kinase subunit is varied. The rate of phosphorylation of tyrosine hydroylase compares favorably with that of H1 histone, a known substrate of protein kinase. Lineweaver-Burk analysis of crude or purified rat pheochromocytoma tyrosine hydroxylase activity, as a function of pterin cofactor concentration, in the absence of ATP, Mg2+, and protein kinase catalytic subunit, yields a curvilinear relationship which can be resolved into two lines, suggesting two enzyme forms with different affinities for pterin cofactor. A fraction of the hydroxylase present in the tumor exists in the activated state, presumably due to the presence of ATP and endogenous protein kinase activity. When the solubl enzyme is activated by cyclic AMP, ATP, Mg2+, and protein kinase, virtually all of the enzyme is converted to the low Km state. We conclude that tyrosine hydroxylase is a substrate of cyclic AMP-dependent protein kinase in vitro and, presumably, in vivo.
Detection of human DNA polymorphisms with a simplified denaturing gradient gel electrophoresis technique. (1987)

Single base pair differences between otherwise identical DNA molecules can result in altered melting behavior detectable by denaturing gradient gel electrophoresis. We have developed a simplified procedure for using denaturing gradient gel electrophoresis to detect base pair changes in genomic DNA. Genomic DNA is digested with restriction enzymes and hybridized in solution to labeled single-stranded probe DNA. The excess probe is then hybridized to complementary phage M13 template DNA, and the reaction mixture is electrophoresed on a denaturing gradient gel. Only the genomic DNA probe hybrids migrate into the gel. Differences in hybrid mobility on the gel indicate base pair changes in the genomic DNA. We have used this technique to identify two polymorphic sites within a 1.2-kilobase region of human chromosome 20. This approach should greatly facilitate the identification of DNA polymorphisms useful for gene linkage studies and the diagnosis of genetic diseases.
Progressive Volume Rendering of Large Unstructured Grids (2006)

We describe a new progressive technique that allows real-time rendering of extremely large tetrahedral meshes. Our approach uses a client-server architecture to incrementally stream portions of the mesh from a server to a client which refines the quality of the approximate rendering until it converges to a full quality rendering. The results of previous steps are re-used in each subsequent refinement, thus leading to an efficient rendering. Our novel approach keeps very little geometry on the client and works by refining a set of rendered images at each step. Our interactive representation of the dataset is efficient, light-weight, and high quality. We present a framework for the exploration of large datasets stored on a remote server with a thin client that is capable of rendering and managing full quality volume visualizations.
Improving IEEE 1588v2 clock performance through controlled packet departures (2010)

Packet delay variation (PDV) is the dominant impairment in packet-based synchronization systems. One way to mitigate its effect is to apply advanced filtering techniques on phase error information derived from packet arrival events. In this letter we consider an alternative approach in which the backpressure to the background traffic source is coordinated with timing packet generation such that the PDV is completely eliminated. Although the proposed method is limited to tree network topologies, the results are notable due to complete elimination of the PDV noise even if the background traffic load approaches 100%.
The Duo Split Acute Hemodialysis Catheter (2000)

Acute hemodialysis catheters are designed to be placed over a guidewire into the central veins by Seldinger technique, and therefore are rigid with a pointed tip. The guidewire technique avoids the need for tunneling the catheter and threading the catheter tip through a thin-walled “sheath” with risk of blood loss or air embolus. Acute catheters generally provide lower and more irregular blood flow than chronic tunneled catheters such as the Ash Split Cath, and average duration of use is limited to a only a few days due to risks of infection or vein irritation. The Duo Split is a flexible acute catheter with two separate intravascular limbs, each with a blunt cylindrical tip and multiple side-holes similar to the Split Cath, but without a cuff and subcutaneous tunnel. A single-slotted “Quill” guide surrounds the catheter during placement, with a tapered tip that follows the guidewire into the vein. Simple traction on the Quill causes the tapered tip and the slot to expand around the catheter, leaving the Duo Split in place within the vein. DuoSplit catheters were placed into the femoral vein (4) and IJ vein (2) of 6 patients with acute renal failure. During dialysis blood flow rates (BFRs) of 200–300 ml/min were obtained (average 229 ml/min) with average venous pressures of 150 mm and average arterial pressures of 192mm. Flow rates and pressures were similar to conventional acute catheters placed mostly in the IJ vein. Duration of Duo Split catheter use was longer at 6.2 days (maximum 11 days) versus 4.0 days for conventional catheters. There were no complications of clotting, septicemia, exit infection or loss of blood flow. The DuoSplit catheter in the femoral or IJ vein provides adequate blood flow rate for treatment of acute renal failure, and may allow longer catheter use than with conventional acute catheters.
Optical Absorption in Ge<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Se</mml:mi></mml:mrow><mml:mrow><mml:mn>0.75</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Te</mml:mi></mml:mrow><mml:mrow><mml:mn>0.25</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (1968)

Ge${\mathrm{Se}}_{0.75}$${\mathrm{Te}}_{0.25}$ is a new IV-VI compound which has electrical properties similar to those of the degenerate semiconductors GeTe and SnTe. Optical absorption has been measured in single crystals of Ge${\mathrm{Se}}_{0.75}$${\mathrm{Te}}_{0.25}$ grown by an iodine transport process. The measurements show a sharp absorption edge followed by a rapid rise in absorption at long wavelengths caused by the large free-carrier concentration (${10}^{20}$ holes ${\mathrm{cm}}^{\ensuremath{-}3}$). The absorption edge is interpreted as the fundamental absorption edge of a semiconductor. It is concluded that Ge${\mathrm{Se}}_{0.75}$${\mathrm{Te}}_{0.25}$ is a degenerate semiconductor which has a band gap considerably less than 0.82 eV.
Mobile Agent Based Authentication for Wireless Network Security (2008)

The explosive growth witnessed by wireless networks is largely due to the flexibility offered to both users and service provider. However, the open wireless medium makes traditional link-layer attacks readily available to anyone within the range of the network. Confidentiality, integrity and authentication pose several challenges to wireless network security implementations. The IEEE 802.11i security framework has some flaws, making the traditional cryptographic mechanism provide weak security for the wireless environment. In this paper we explore the feasibility of mobile agents to provide secured access control for next generation wireless infrastructure networks.
Spatial complexity based optimal initial quantization parameter determination (2015)

In this paper, we propose a method to initialize the quantization parameter (QP) for H.264/AVC video coding. The objective is to achieve a better video quality and lower bitrate fluctuations by adopting a properly setting initial QP. By taking grey level co-occurrence matrix (GLCM) into consideration of the single-frame spatial complexity, the initial QP is determined by target bitrate as well as the video content. Experimental results show that the proposed method outperforms JVT-G012 and a recent model by higher PSNR and fewer bitrate variations.
3D simulation of controlled micromachined capacitive ultrasound transducers (2003)

A finite element simulation scheme which allows the efficient calculation of electrostatic transducers immersed in an acoustic fluid is presented. This calculation scheme has been applied in investigations of the dynamical behavior of surface micromachined capacitive ultrasound arrays. In order to improve dynamics and efficiency of such transducers a controller has been designed and tested. Therewith, ring down time and acoustic crosstalk in the array are reduced.
Online estimation and application of power grid impedance matrices based on synchronised phasor measurements (2010)

Grid impedance matrices estimation is important in monitoring and protection of wide-area power systems. In this study, a recursive least-squares estimation algorithm with a forgetting factor is presented to identify impedance parameters of power grids. This approach is based on synchronised phasor measurements and makes it possible to track changing parameters. The algorithm is tested on two power systems using MATPOWER-generated data, and case studies are conducted for estimation of grid impedances followed by voltage stability margin analysis and fault detection. The results show that the proposed method is effective for online estimation of grid impedances, fault detection and voltage stability monitoring.
All screen printed dye solar cell (2007)

All screen printed Dye Sensitized Solar cell modules were fabricated and demonstrated excellent electrical performances thanks to a monolithic interconnection based on highly conductive carbon layers. Attained efficiency at 1000 W/m<sup>2</sup> is 6 % with a fill-factor of 0.7. This monolithic module is very elegant to manufacture since the layers, including nano- TiO<sub>2</sub> spacer, catalytic active layer, conductive carbon and sealing are all printed. Such a module only requires one transparent conductive substrate which allows substantial manufacturing cost reductions. Moreover, only one co-firing cycle is sufficient, thus lowering the required energy at production. In addition, a quick staining process enables in-line production techniques. Modules of 10 x 10 cm are now being built for sampling and performance testing.
Leg ulcers: a practical approach to the leg ulcer patient. (1995)

Wound care has become a complicated science and specialty field of its own; however, all patients are initially seen by the primary care provider, and it is here that the greatest impact on wound healing and limb salvage can be made. Clinicians frequently treat chronic leg ulcers with a variety of products at various costs to the patients and third party payors based on experience not scientific literature, making the interpretation of outcomes difficult. With the problem of leg ulcers being so common, this paper sets out to review the basics of wound healing common to all wounds and to describe the current concepts of management of the three most common leg ulcers seen in a typical outpatient wound clinic setting: venous stasis ulcers, ischemic ulcers, and diabetic foot ulcers.
Mucolipins: Intracellular TRPML1‐3 channels (2010)

The mucolipin family of Transient Receptor Potential (TRPML) proteins is predicted to encode ion channels expressed in intracellular endosomes and lysosomes. Loss-of-function mutations of human TRPML1 cause type IV mucolipidosis (ML4), a childhood neurodegenerative disease. Meanwhile, gain-of-function mutations in the mouse TRPML3 result in the varitint-waddler (Va) phenotype with hearing and pigmentation defects. The broad spectrum phenotypes of ML4 and Va appear to result from certain aspects of endosomal/lysosomal dysfunction. Lysosomes, traditionally believed to be the terminal "recycling center" for biological "garbage", are now known to play indispensable roles in intracellular signal transduction and membrane trafficking. Studies employing animal models and cell lines in which TRPML genes have been genetically disrupted or depleted have uncovered roles of TRPMLs in multiple cellular functions including membrane trafficking, signal transduction, and organellar ion homeostasis. Physiological assays of mammalian cell lines in which TRPMLs are heterologously overexpressed have revealed the channel properties of TRPMLs in mediating cation (Ca(2+)/Fe(2+)) efflux from endosomes and lysosomes in response to unidentified cellular cues. This review aims to summarize these recent advances in the TRPML field and to correlate the channel properties of endolysosomal TRPMLs with their biological functions. We will also discuss the potential cellular mechanisms by which TRPML deficiency leads to neurodegeneration.
Unsaturated heterocyclic systems. XL. Evaluation of spiro[9,10-ethanoanthracene-11,2'-thietane] S,S-dioxides and 2.alpha.-dialkylaminoalkyl-3-dialkylaminothietane 1,1-dioxides as precursors of 2-methylenethiete 1,1-dioxide derivatives (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnsaturated heterocyclic systems. XL. Evaluation of spiro[9,10-ethanoanthracene-11,2'-thietane] S,S-dioxides and 2.alpha.-dialkylaminoalkyl-3-dialkylaminothietane 1,1-dioxides as precursors of 2-methylenethiete 1,1-dioxide derivativesLeo A. Paquette, Melvin Rosen, and Heinz StuckiCite this: J. Org. Chem. 1968, 33, 8, 3020–3027Publication Date (Print):August 1, 1968Publication History Published online1 May 2002Published inissue 1 August 1968https://pubs.acs.org/doi/10.1021/jo01272a003https://doi.org/10.1021/jo01272a003research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lightweight Metal Cellular Structures via Indirect 3D Printing and Casting (2012)

Cellular materials offer high strength accompanied by low-density and can offer high stiffness, good impact-absorption, and thermal and acoustic insulation. In this paper, the authors describe their progress towards exploring the use of metal casting into 3D printed sand molds for creating cellular materials and sandwich panels. The use of 3D printing allows for the fabrication of sand molds without the need for a pattern, and thus enables the creation of cellular structures with designed mesostructure from a bevy of metal alloys. The quality-of-fill results for several cast aluminum cellular parts of varying geometry are presented in this paper, along with a discussion of overall truss diameter variation.
<b>STIMULATION OF DNA SYNTHESIS IN ADULT RAT HEPATOCYTES IN PRIMARY CULTURE BY SERA FROM PATIENTS WITH FULMINANT HEPATIC </b><b>FAILURE </b> (1985)

The effect of sera from nine patients with fulminant hepatic failure on liver cell growth was investigated by use of adult rat liver cells in primary culture. All nine sera stimulated DNA synthesis in hepatocytes more effectively than normal human serum, which had only slight growth-promoting activity. Moreover four of the sera showed marked stimulatory activity on DNA synthesis of more than 10 times that of normal human serum. The serum with the highest activity had a dose-dependent effect, and its effect at 10% concentration was greater than that of a combination of the optimal concentrations of insulin and epidermal growth factor. Autoradiographic and morphological data showed that cells that replicated and increased in number in the presence of this serum were parenchymal hepatocytes.
Introduction (1996)

The present manual is intended as a tool for the identification of cosmopolitan parasites affecting domestic animals. Special attention has been paid to imported or autochthonous parasitic infections occurring in African livestock, including dromedaries. In the course of compiling this work, a summary was made of the activities of some 300 institutions (national veterinary health departments, research institutes, universities, private enterprises etc.) dealing with the research, diagnosis and control of parasitic diseases in Africa. Both francophone and anglophone literature has been considered.
Candidate subcircuits for functional module identification in logic circuits (2000)

Recovering functional information from existing hardware is a difficult problem in design automation. However, it is an important focus for designers attempting to redesign for expanded functionality or superior performance. Often, the only reliable information available about a piece of digital hardware is the hardware itself. Documentation, even if it is available, may be outdated or incorrect. Existing procedures are able to recover the transistor-level netlist, or a gate-level netlist from an existing implementation. The next step in this process is the gate-level to module-level transformation, the focus of this paper. We have designed a technique to enumerate all of the potential modules within a gate-level netlist so that their functional equivalence to known modules may be evaluated.
Trade-off analysis of PHY-Aware MAC in low-rate low-power UWB networks (2005)

We are interested in the design of physical-layer-aware medium access control for self-organized low-power low-data-rate impulse radio ultra-wideband (IR-.UWB) networks.. In such networks energy consumption is much more of a concern than achieved data rates. So far, a number of different solutions have been proposed in the context of data rate efficiency for IR-UWB. However, the choices made for rate-efficient designs are not necessarily optimal when considering energy efficiency. Hence, there is a need to understand the design trade-offs in very low-power networks, which is the aim of this article. To this end, we first identify what a PHY-aware MAC design has to achieve: interference management, access to a destination, and sleep cycle management. Second, we analyze how these functions can be implemented, and provide a list of the many possible building blocks that have been proposed in the literature. Third, we use this classification to analyze fundamental design choices. We propose a method for evaluating energy consumption already in the design phase of IR-UWB systems. Last, we apply this methodology and derive a set of guidelines; they can be used by system architects to orientate fundamental choices early in the design process.
La importancia jurídica y económica del Seguro de Crédito en tiempos de crisis (2009)

Las aseguradoras de credito son uno de los principales soportes que, gestionando el credito comercial, permiten acolchar los violentos giros de confianza propios de todo sistema financiero, atenuando sus extremados efectos y permitiendo un crecimiento mas estable y regular de la realidad economica. Esto no significa quehaya que sobreestimar la intervencion del seguro de credito en el sistema economico ni de verlo como una panacea. Los beneficios que brinda dicho seguro pasan por una actuacion responsable y leal del asegurado.
A very facile, low temperature, one-step route to in situ fabricate copper sulfide nanosheet thin films (2011)

CuS nanosheet thin films with large areas were synthesized in situ on copper substrates through a facile, one-step treatment of copper foil and sulfur powder in the presence of N,N-dimethylformamide (DMF) at low temperature (60 °C or less). Compared with the previous reported solvothermal approach, the current low temperature route is simpler, low cost and low energy consumption. The effects of the reaction temperature on the synthesis and the optical property of CuS nanosheet films were investigated. The resulting CuS nanosheet films were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), selected area electron diffraction (SAED) and UV–vis spectrometer. In this study, we also demonstrated this method to prepare copper sulfide nanosheet films on ground-glass and indium tin oxide glass (ITO) substrates. We found that perfect nanosheet crystals could be obtained in all cases. The growth mechanism of CuS nanosheet-based films was proposed. The current method may open up a new way to prepare thin films of metal sulfide at low temperatures.
What Customers Want: Using Outcome-Driven Innovation to Create Breakthrough Products and Services (2005)

A world-renowned innovation guru explains practices that result in breakthrough innovations. Twenty years into the customer-driven innovation movement, breakthroughs are rare and these failures cost Fortune 1000 companies between $50 million and $800 million each year. Growing out of Anthony Ulwick's revolutionary Harvard Business Review article and featured in Clayton Christensen's new bestseller, The Innovator's Solution, What Customers Want describes a groundbreaking approach that improves on the conventional methods for product and service innovation.
Workflow-Based Integration Framework for Medication-Use Process (2007)

The use of medications is ubiquitous in terms of location and time. Medication-use system includes the prescription entry sub-system in hospitals and clinics, prescription refill subsystems in pharmacies, and medication dispensing subsystems for medication users. Fortunately, many of the medication-use injuries are preventable. Integrating medication sub-systems and automating the medication process enhance the medication compliance and prevent the medication errors, caused by communication mistakes between care-takers and medical institutes. There are many attempts to integrate medication-use sub-systems to help the patient in hospital or outpatient settings to comply with medication directions. Many of them are designed and implemented with typical medication-use process and most of the systems are implemented as a tightly-coupled close system.