gebhart/patrepeval huggingface dataset:
An Improved Process for Pioglitazone and Its Pharmaceutically Acceptable Salt (2009)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to Edi...Communication to EditorNEXTAn Improved Process for Pioglitazone and Its Pharmaceutically Acceptable Salt†Lokeswara Rao Madivada‡, Raghupathi Reddy Anumala‡, Goverdhan Gilla‡, Sampath Alla‡, Kavitha Charagondla‡, Mukkanti Kagga§, Apurba Bhattacharya‡, and Rakeshwar Bandichhor*‡View Author Information Innovation Plaza, IPD, R&D, Dr. Reddy's Laboratories Ltd., Survey Nos. 42, 45,46, and 54, Bachupally, Qutubullapur, R.R. District - 500 073, Andhra Pradesh, India, and Institute of Science and Technology, Center for Environmental Science, JNT University, Kukatpally, Hyderabad - 500 072, Andhra Pradesh, India†DRL-IPD Communication number: IPDO-IPM-00169.* Corresponding author. E-mail: [email protected]. Telephone: +91 4044346000. Fax: +91 4044346285.‡Innovation Plaza, IPD, R&D, Dr. Reddy's Laboratories Ltd.§Institute of Science and Technology, Center for Environmental Science, JNT University.Cite this: Org. Process Res. Dev. 2009, 13, 6, 1190–1194Publication Date (Web):September 29, 2009Publication History Received26 May 2009Published online29 September 2009Published inissue 20 November 2009https://pubs.acs.org/doi/10.1021/op900131mhttps://doi.org/10.1021/op900131mrapid-communicationACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views2457Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anions,Aromatic compounds,Hydrocarbons,Optimization,Solvents Get e-Alerts
Growing pains—and successes—in transforming the information systems organization for client/server development (1995)

Information systems (IS) groups are under increasing pressure to contribute to organizational performance and to support, or even drive, broad organizational transformation efforts through the successful exploitation of information technology (IT). Using a "sociocentric" model of organizational work, this paper analyzes the experiences of one company's IS group that recently embarked on a long-term, enterprise-wide client/server system development initiative designed to transform organizational decision support processes. Even though the client/server initiative is still in its infancy and has not yet delivered high-impact applications, it has brought about substantial changes in the nature of work in the IS group. These changes range from new philosophies, methodologies, and technologies to shifts in the skills, communication patterns, control structures and management styles required to develop and manage information systems.
Geometric Measures of Poincare Plots for the Detection of Small Sympathovagal Shifts (2007)

The Poincare plot has been a nonlinear tool for the analysis of heart rate variability. However, due to a lack of tools to quantitatively characterize the plots, the Poincare plot has been used visually only. One of the problems with a Poincare plot of a large number of R-R intervals has been the outliers. These make the plots much larger than they should be while contributing relatively little from a density point of view. By concentrating on the central R-R pairs the outliers can be ignored. A contour that includes 90% of the R-R pairs is used. The mean R-R values, the histogram and the 90% contour are used to characterize the Poincare plots. Holter recordings from 4 hours of night sleep during normal and mild hyperglycaemic episodes will be compared using the new set of tools.
Early season co-circulation of influenza A(H3N2) and B(Yamagata): interim estimates of 2017/18 vaccine effectiveness, Canada, January 2018 (2018)

Using a test-negative design, we assessed interim vaccine effectiveness (VE) for the 2017/18 epidemic of co-circulating influenza A(H3N2) and B(Yamagata) viruses. Adjusted VE for influenza A(H3N2), driven by a predominant subgroup of clade 3C.2a viruses with T131K + R142K + R261Q substitutions, was low at 17% (95% confidence interval (CI): -14 to 40). Adjusted VE for influenza B was higher at 55% (95% CI: 38 to 68) despite prominent use of trivalent vaccine containing lineage-mismatched influenza B(Victoria) antigen, suggesting cross-lineage protection.
PIANO SOLO (1969)

Journal Article PIANO SOLO Get access Phillip Ramey, Epigrams. ( Boosey & Hawkes, London, 1968, 7s. 6d.) Anton Webern, Kinderstück. ( Boosey & Hawkes, London, 1967, 4s.) E. P. E. P. Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume L, Issue 3, July 1969, Pages 424-b–425, https://doi.org/10.1093/ml/L.3.424-b Published: 01 July 1969
Cerebral Apoplexy (Stroke): Pathogenesis, Pathophysiology and Therapy as Illustrated by Regional Blood Flow Measurements in the Brain (1971)

Pathophysiological and pathogenetic concepts, particularly in occlusive cerebrovascular disease, are reviewed and discussed with emphasis on the results of current research. Therapy is discussed in the context of these concepts. When focal ischemia, with or without cerebral infarction, is not associated with definable arterial occlusion, studies of regional cerebral blood flow strongly support the thromboembolic theory; the arterial defect is relatively transient and is caused by an embolus or thrombus which rapidly disappears (fragments or is lysed). The treatment of transient ischemic attacks by the administration of anticoagulant or surgical reconstruction of the appropriate artery is discussed. When cerebral infarction is caused by arterial occlusion there is vasomotor paralysis (loss of autoregulation and of reactivity to carbon dioxide). In some instances hypercapnia apparently causes only the vessels in nonaffected brain to dilate so that an increased amount of blood streams to these parts while blood pressure falls in collaterals leading to the focus and blood flow to the infarct is decreased (steal syndrome). If blood flow is decreased to nonaffected brain, by vasoconstriction caused by hyperventilation, increased amounts of blood may be shunted into the infarct (reverse steal) where autoregulation is lost. Vasoconstriction, as a treatment, might be beneficial. However, in patients with severe cerebral infarction no convincing favorable affect has been noted. The potential therapeutic action of hyperventilation in patients with mild cerebral infarction has not been studied. Extensive (global) changes in the cerebral blood flow in cerebral infarction, certain aspects of intracerebral hemorrhage, and the role of hypertension in cerebrovascular disease are also dealt with.
Drug Absorption With Food (2004)

Oral input is the most convenient route for drug administration so the large majority of drug products are oral dosage forms. This dictates consideration of the timing of drug administration with respect to the time of meal ingestion. There are several reasons for taking a drug with a meal or nutrient beverage. It may be expedient for clinical staff in hospitals and assisted living centers to administer a drug at a time when meals are provided for inpatients. Outpatient compliance with the prescribed drug dosage regimen may be aided with administration at regular mealtimes. Some drugs are irritating in the gastrointestinal (GI) tract and their administration with food or a nutrient beverage can diminish this effect as compared to administration with water.
Progress in skutterudite-based thermoelectric materials (2002)

The progress in skutterudite-based thermoelectric materials in our group is reviewed. The effect of the filling fraction on the transport properties of skutterudite material was investigated. It has been found that the partially filled skutterudite with lower filling fraction has better electric transport properties than fully filled skutterudite. Raman scattering investigations on filled skutterudite with different filling fractions has indicated that the rattling degree of the filling atoms in the voids in skutterudite decreases with the increase of the filling fraction. Filled skutterudite NaFe/sub 4/P/sub 12/ nanowires of 25-80 nm in diameter and 500-4000 nm in length have been obtained by using novel hydrothermal-reduction-alloying method. The nanowire can be arrayed directionally the magnetic field. A polyaniline/skutterudite thermoelectric composite was synthesized by using an in situ compounding method. An investigation into the electric transport properties of the composite has been carried out.
Modulation of Hippocampal Plasticity and Cognitive Behavior by Short-term Blueberry Supplementation in Aged Rats (2004)

During aging, reductions in hippocampal neurogenesis are associated with memory decline indicating a causal relationship. Indeed, insulin-like growth factor-1 (IGF-1), a major activator of the extracellular receptor kinase pathway that is central in learning and memory processes, is also a key modulator of hippocampal neurogenesis. Previously, we showed that age-related declines in spatial memory tasks can be improved by antioxidant-rich diets containing blueberries. In this study, to begin to understand the mechanisms responsible for the beneficial effects of blueberries, we assessed changes in hippocampal plasticity parameters such as hippocampal neurogenesis, extracellular receptor kinase activation, and IGF-1 and IGF-1R levels in blueberry-supplemented aged animals. Our results show that all these parameters of hippocampal neuronal plasticity are increased in supplemented animals and aspects such as proliferation, extracellular receptor kinase activation and IGF-1 and IGF-1R levels correlate with improvements in spatial memory. Therefore, cognitive improvements afforded by polyphenolic-rich fruits such as blueberries appear, in part, to be mediated by their effects on hippocampal plasticity.
Acute Injury in Natural Diet-Induced Fatty Livers - A Model for Therapy Development (2016)

Given the diabesity and metabolic syndrome epidemics, fatty liver disease is reaching epidemic proportions. Relatively indolent, this disease is often asymptomatic and the patient is often made aware of its presence only during a routine physical exam. Nevertheless, fatty livers are more susceptible to insult compared to their non-fatty counterparts and persons with fatty livers are at increased risk for morbidity and mortality following consumption of commonly used substances such as alcohol (EtOH) and acetaminophen (APAP). We have developed a rat model of natural diet-induced fatty liver disease and evaluated the effects of two commonly used substances viz. EtOH and APAP in this phenotype. High fat diet (HFD) fed animals exhibited steatosis, liver inflammation and liver fibrosis with an increase in serum aspartate aminotransferase. Bolus administration of EtOH, which was without effect on the livers from standard diet fed animals, had a profound and adverse impact on the HFD fatty liver. Similarly, APAP administration which was without effect on liver function tests in control animals, also provoked an increase in liver enzymes in HFD animals. Treatment with the poly(ADP-ribose) polymerase-1 inhibitor (PARP-1), veliparib, reduced the increase in liver function tests secondary to EtOH and APAP. This model forms the framework for identification of fatty liver disease biomarkers given that this disease is relatively asymptomatic but fraught with risk for acute injury. This model also forms the framework for evaluation of novel drugs for acute injury in fatty livers especially given that current strategies for management of acute liver failure in non-fatty livers are inadequate. Also, relevant patents related to the use of liver biomarkers as diagnostic are discussed.
Bayesian Methods of Astronomical Source Extraction (2007)

We present two new source extraction methods, based on Bayesian model selection and using the Bayesian information criterion. The first is a source detection filter, which is able to simultaneously detect point sources and estimate the image background. The second is an advanced photometry technique that measures the flux, position (to subpixel accuracy), local background, and point-spread function. We apply the source detection filter to simulated Herschel SPIRE data and demonstrate the filter's ability to both detect point sources and simultaneously estimate the image background. We use the photometry method to analyze a simple simulated image containing a source of unknown flux, position, and point-spread function; we not only accurately measure these parameters but also determine their uncertainties (using Markov chain Monte Carlo sampling). The method also characterizes the nature of the source (distinguishing between a point source and an extended source). We demonstrate the effect of including additional prior knowledge. Prior knowledge of the point-spread function increases the precision of the flux measurement, while prior knowledge of the background has only a small impact. In the presence of higher noise levels, we show that prior positional knowledge (such as might arise from a strong detection in another wave band) allows us to accurately measure the source flux even when the source is too faint to be detected directly. These methods are incorporated in SUSSEXtractor, the source extraction pipeline for the forthcoming Akari Far-Infrared Surveyor all-sky survey. They are also implemented in a stand-alone, beta-version tool that is freely available.
Volume Index (2006)

The Journal of Income Distribution aims to facilitate communication and discussion of research in the field of social economics and particularly in the sphere of the distribution of income and wealth. Its intention is to provide an international forum for the dissemination of the results of scholarly work in this field.
Selective Electrosynthesis of (Trimethylsilyldifluoro)methylbenzene, a PhCF2- Precursor; Conditions for a Molar Scale Preparation without HMPA (1999)

Electrochemical reductive silylation of trifluoromethylbenzene by the sacrificial anode technique selectively led, in a THF/DMPU mixture instead of THF/HMPA and according to the charge passed, to the corresponding mono-, bis- or tris-trimethylsilyl derivatives, respectively PhCF2 TMS, PhCF(TMS)2 and PhC(TMS)3. This reaction, without any chemical equivalent, was extended to a molar scale synthesis, using a tubular flow cell.
Recombinant N–Terminal Slit2 Inhibits TGF-β–Induced Fibroblast Activation and Renal Fibrosis (2016)

Fibrosis and inflammation are closely intertwined injury pathways present in nearly all forms of CKD for which few safe and effective therapies exist. Slit glycoproteins signaling through Roundabout (Robo) receptors have been described to have anti-inflammatory effects through regulation of leukocyte cytoskeletal organization. Notably, cytoskeletal reorganization is also required for fibroblast responses to TGF-β Here, we examined whether Slit2 also controls TGF-β-induced renal fibrosis. In cultured renal fibroblasts, which we found to express Slit2 and Robo-1, the bioactive N-terminal fragment of Slit2 inhibited TGF-β-induced collagen synthesis, actin cytoskeletal reorganization, and Smad2/3 transcriptional activity, but the inactive C-terminal fragment of Slit2 did not. In mouse models of postischemic renal fibrosis and obstructive uropathy, treatment with N-terminal Slit2 before or after injury inhibited the development of renal fibrosis and preserved renal function, whereas the C-terminal Slit2 had no effect. Our data suggest that administration of recombinant Slit2 may be a new treatment strategy to arrest chronic injury progression after ischemic and obstructive renal insults by not only attenuating inflammation but also, directly inhibiting renal fibrosis.
Learning Conjunctions of Horn Clauses (Extended Abstract) (1990)

We have applied a refined microdissection procedure to create a plasmid library of the barley (Hordeum vulgare L.) chromosome arm 1HS. The technical improvements involved include synchronization of meristematic root tissue, a metaphase drop-spread technique, paraffin protection of the collection drop to avoid evaporation, and a motorized and programmable microscope stage. Thirteen readily-discernible telocentric chromosomes have been excised from metaphases of synchronized root-tip mitoses. After lysis in a collection drop (2 nl), the DNA was purified, restricted withRsaI, ligated into a vector containing universal sequencing primers, and amplified by the polymerase chain reaction. Finally, the amplified DNA was cloned into a standard plasmid vector. The size of the library was estimated to be approximately 44,000 recombinant plasmids, of which approximately 13% can be utilized for RFLP analysis. Tandem repetitive probes could be rapidly excluded from further analysis after colony hybridization with labelled total barley DNA. Analysis of 552 recombinant plasmids established that: (1) the insert sizes ranged between 70 and 1150 bp with a mean of 250 bp, (2) approximately 60% of the clones contained highly repetitive sequences, and (3) all single- or low-copy probes tested originate from chromosome 1HS. Four probes were genetically mapped, using an interspecificH. vulgare xH. spontaneum F2 population. One of these probes was found to be closely linked to theMla locus conferring mildew resistance.
Current status of the availability, development, and use of host plant resistance to nematodes. (1992)

Host plant resistance (HPR) to nematodes has been identified in many major crops and related wild germplasm. Most HPR is to the more specialized, sedentary endoparasitic genera and species, e.g., Globodera, Heterodera, Meloidogyne, Nacobbus, Rotylenchulus, and Tylenchulus. Some HPR has been developed or identified also to certain migratory endoparasites (Aphelenchoides, Ditylenchus, Pratylenchus, Radopholus) in a few hosts. Commercial use of HPR remains limited, despite its benefits to crop production when deployed appropriately. Restricted use and availability of HPR result from problems associated with transfer of resistance into acceptable cultivars. Difficulties occur in gene transfer to acceptable cultivars because of incompatibility barriers to hybridization or linkage to undesirable traits, for example in cucurbitaceous and solanaceous crops and sugarbeet. Specificity of HPR to only one species, or one or few pathotypes, as it relates to resistance durability and nematode virulence, and HPR response to abiotic factors such as high soil temperature, also limit availability and utility. A scheme for HPR development is presented to emphasize nematology research and information requirements for expanding HPR use in nematode control programs, for example in common bean, sugarbeet, and tomato. Nonbiological factors that influence HPR usage are discussed, including heavy reliance on nematicide programs, low priority of nematode HPR in many breeding programs, and insufficient breeder-nematologist collaboration.
HandSense (2019)

Head-mounted devices (HMD) for Augmented Reality (AR) are gaining traction thanks to a growing number of applications in the areas of image guided therapy, computer aided design, cargo packing, manufacturing and digital field service. However, providing an always available, intuitive and user friendly input for these devices remains a challenging problem. This paper explores recognizing dynamic, micro finger gestures using capacitive coupling for interacting with a head-mounted device. Electrodes are attached to fingertips of users gloves and capacitive coupling among all pairs of electrodes is measured quickly to infer the real-time spatial relationship between fingers. The system is able to recognize fine, low-effort finger gestures, such as swiping, sliding, tap, double-tap. We evaluated our prototype with 14 gestures executed by 10 subjects and found a 97% accuracy of gesture recognition.
Molecular Characterization of Jurkat Cells Persistently Infected with Vaccinia Virus Mutant Vp811 (2005)

Previous reports from this laboratory demonstrated that persistent infections could be established in Jurkat cells with wild-type vaccinia virus (Jvac). The infected cells elicit increased expression of IL-2, IL-2Ralpha and IL-6 but not of IL-1beta nor of interferon-gamma. The persistently infected cells are also capable to transactivate the LTR gene of HIV-1 virus (HIV-1LTR). In addition, NFkappabeta and NFAT are found activated in Jvac. To find out whether the gene(s) responsible for establishment, maintenance and molecular characteristics of persistently infected cells are located in the terminal ends of the molecule, Jurkat cells were infected with a deletion mutant Vp811 that lacks 32.7 and 14.9 kb at the left and right terminal, respectively. The results indicate that the deletion mutant is capable of establishing persistent infections. The persistently infected cells show a similar pattern of expression to that observed in Jvac cells. It is concluded that the viral gene(s) involved in persistence and molecular cellular changes is (are) present in the mutant.
C1q-Fixing Human Leukocyte Antigen Antibodies Are Specific for Predicting Transplant Glomerulopathy and Late Graft Failure After Kidney Transplantation (2010)

Monitoring patients with the C1q assay, which detects antibodies that fix complement, offers a minimally invasive means of identifying patients at risk for transplant glomerulopathy and graft loss.