gebhart/patrepeval huggingface dataset:
Anti-inflammatory stent coatings: dexamethasone and related compounds. (1999)

The dexamethasone-eluting stent was a well-tolerated and effective means of providing sustained site-specific drug delivery to the porcine coronary artery wall for 28 days, although longer-term biocompatibility of the polymer coating was not assessed. Dexamethasone did not reduce the neointimal hyperplastic response to injury, despite sustained tissue levels of drug.
Regulatory T cells: Mechanisms of suppression and impairment in autoimmune liver disease (2015)

There are three classic liver diseases with probable autoimmune etiology: primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis. The occurrence of these autoimmune conditions is determined by the breakdown of immune-regulatory mechanisms that in health are responsible for maintaining immunological tolerance against self-antigens. Among the multiple T cell subsets with suppressive function, the regulatory T cells (Tregs), defined by the expression of CD4, the IL-2 receptor α chain (CD25), and the transcription factor FOXP3, have emerged as having a central role in maintaining immune-tolerance to autoantigens. Tregs are equipped with an array of mechanisms of suppression, including the modulation of antigen presenting cell maturation and function, the killing of target cells, the disruption of metabolic pathways, and the production of anti-inflammatory cytokines. In all the three autoimmune liver diseases mentioned above, there is evidence pointing for either a reduced frequency and/or function of Tregs. Here, we review the definition, phenotypic characteristics, and mechanisms of suppression employed by Tregs and then we discuss the evidence available pointing to their impairment in patients with autoimmune liver disease.
Dielectric switching with memory in thin films of stearic acid (1985)

Stearic acid (CH3-CH216-COOH) films were deposited by thermal evaporation under vacuum. Thin-film capacitors were formed as aluminium-stearic acid-aluminium/gold structures. These devices exhibited dielectric memory switching between two stable states. This effect is analysed and discussed.
Planificación del entrenamiento deportivo en el taekwondo atendiendo a las zonas de producción de energía en las diferentes direcciones de la preparación (2006)

Se muestran los resultados del empleo de una metodologia para la planificacion del entrenamiento por sistemas de energeticos (direcciones del entrenamiento), diferente a la usada hasta este momento. Se utiliza un grupo de tablas para la determinacion de los volumenes y la intensidad de la carga. Las tablas se confeccionaron tomando como base las recomendadas en la literatura especializada y la experiencia en el entrenamiento de este deporte. Para la validacion de la metodologia y las tablas se estudio un grupo de 12 atletas, de taekwondo de la EIDE Carlos Leyva de Las Tunas, durante cuatro macrociclos de entrenamientos sistematicos. Los test aplicados mostraron incrementos significativos con un nivel de confianza del 95 % en las diferentes etapas de cada ciclo de entrenamiento y durante los cuatro ciclos y en el orden competitivo se obtienen 32 medallas en los Juegos Nacionales Escolares de alto rendimiento y por equipos, 3 segundos lugares y un primero.
Micro-Doppler effect of micromotion dynamics: a review (2003)

In this paper, we review the micro-Doppler effect induced by micro-motion dynamics and provide mathematics of the micro-Doppler effect by introducing micro motions to the conventional Doppler effect. Micro-Doppler effect was originally introduced in laser systems, but it can also be observed in microwave radar systems. We introduce some interesting results on observing micro-Doppler phenomenon using microwave radar systems and potential applications to target’s feature extraction.
Truth Cube: Establishing Physical Standards for Real Time Soft Tissue Simulation (2001)

Accurate and real-time models of soft tissue behavior are key elements in the development of medical simulation systems. However, precise validation of these models remains a challenge. Currently, real-time modeling is at best validated against FEM models that have their own intrinsic limitations. This study is the first in a series that will develop physical standards resulting in a database of relevant information used to validate real-time soft tissue deformation. In this first study, a simple 8cm cube of silicone rubber with an exact pattern of embedded Teflon beads was tested in uniaxial compression while CT images were taken. The known material properties, geometry, and carefully controlled boundary conditions resulted in a complete set of volumetric displacement data. The results were also compared to an FEM analysis of an identical situation. This work has served as a proof of concept for a robust physical standard for use in validating real time models. A web site has been created to provide access to our database at: http://biorobotics.harvard.edu/truthcube /.
A Noncoherent Space-Time Code from Quantum Error Correction (2019)

In this work, we develop a space-time block code for noncoherent communication using techniques from the field of quantum error correction. We decompose the multiple-input multiple-output (MIMO) channel into operators from quantum mechanics, and design a non-coherent space time code using the quantum stabilizer formalism. We derive an optimal decoder, and analyze the former through a quantum mechanical lens. We compare our approach to a comparable coherent approach and a noncoherent differential approach, achieving comparable or better performance.
Formation of strong light-trapping nano- and microscale structures on a spherical metal surface by femtosecond laser filament (2012)

Nano- and microscale structures on a material surface formed by femtosecond laser processing have greatly changed optical characteristics, wettability, as well as other properties of the material. In this work, we report the formation of nano- and microscale structures on a spherical Al surface with femtosecond laser filament, and find that the filament-processed surface has a strong light-trapping ability from UV to IR (0.2–2.5 μm). Our result demonstrates that this method can be used to process a spherical surface without the complexity of a 4-axis sample control, and in principle, it is applicable to any non-planar sample.
Flip-Rotate-Pooling Convolution and Split Dropout on Convolution Neural Networks for Image Classification (2015)

This paper presents a new version of Dropout called Split Dropout (sDropout) and rotational convolution techniques to improve CNNs' performance on image classification. The widely used standard Dropout has advantage of preventing deep neural networks from overfitting by randomly dropping units during training. Our sDropout randomly splits the data into two subsets and keeps both rather than discards one subset. We also introduce two rotational convolution techniques, i.e. rotate-pooling convolution (RPC) and flip-rotate-pooling convolution (FRPC) to boost CNNs' performance on the robustness for rotation transformation. These two techniques encode rotation invariance into the network without adding extra parameters. Experimental evaluations on ImageNet2012 classification task demonstrate that sDropout not only enhances the performance but also converges faster. Additionally, RPC and FRPC make CNNs more robust for rotation transformations. Overall, FRPC together with sDropout bring $1.18\%$ (model of Zeiler and Fergus~\cite{zeiler2013visualizing}, 10-view, top-1) accuracy increase in ImageNet 2012 classification task compared to the original network.
Measurable Outcomes of Quality Improvement in the Trauma Intensive Care Unit: The Impact of a Daily Quality Rounding Checklist (2008)

Introducing a daily QRC tool facilitated improved compliance rates for 16 clinically significant prophylactic measures in a busy Level I trauma ICU. The daily use of this tool, requiring just a few minutes per patient to complete, results in a sustainable improvement in patient outcomes.
Efflux-Mediated Antibiotic Resistance in <i>Acinetobacter</i> spp (2010)

Among Acinetobacter spp., A. baumannii is the most frequently implicated in nosocomial infections, in particular in intensive care units. It was initially thought that multidrug resistance (MDR) in this species was due mainly to horizontal acquisition of resistance genes. However, it has recently become obvious that increased expression of chromosomal genes for efflux systems plays a major role in MDR. Among the five superfamilies of pumps, resistance-nodulation-division (RND) systems are the most prevalent in multiply resistant A. baumannii. RND pumps typically exhibit a wide substrate range that can include antibiotics, dyes, biocides, detergents, and antiseptics. Overexpression of AdeABC, secondary to mutations in the adeRS genes encoding a two-component regulatory system, constitutes a major mechanism of multiresistance in A. baumannii. AdeIJK, intrinsic to this species, is responsible for natural resistance, but since overexpression above a certain threshold is toxic for the host, its contribution to acquired resistance is minimal. The recently described AdeFGH, probably regulated by a LysR-type transcriptional regulator, also confers multidrug resistance when overexpressed. Non-RND efflux systems, such as CraA, AmvA, AbeM, and AbeS, have also been characterized for A. baumannii, as have AdeXYZ and AdeDE for other Acinetobacter spp. Finally, acquired narrow-spectrum efflux pumps, such as the major facilitator superfamily (MFS) members TetA, TetB, CmlA, and FloR and the small multidrug resistance (SMR) member QacE in Acinetobacter spp., have been detected and are mainly encoded by mobile genetic elements.
1. Internal Layers (1988)

1. Dynamics of internal layers: Asymptotics and matching.
Electroabsorption in ultranarrow-barrier GaAs/AlAs multiple quantum well modulators (2002)

Summary form only given. In conclusion although we observe the QCSE in GaAs/AlAs MQW modulators for barriers as thin as 10 /spl Aring/, optimum electroabsorption for smart pixels is found for 20-30 /spl Aring/ barrier width.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Kinetic analysis of interaction of human immunodeficiency virus reverse transcriptase with alkaloids]. (1995)

The interactions of HIV-I reverse transcriptase with some alkaloids were studied. Among nine compounds tested three--berberine, palmatine and sanguiritrine--inhibited RT. The dependence of the inhibition on the type of template-primer was also demonstrated. The kinetic analysis as well as circular dichroism experiments suggest the complex mechanism of RT inhibition by alkaloids. This mechanism includes both enzyme-alkaloid and alkaloid-template interactions; the latter effect also results in RT inhibition.
IMPROVING INTERBUS TRANSFER WITH AUTOMATIC VEHICLE LOCATION (1995)

One of the most consistent public frustrations with bus systems is their perceived, and frequently actual, lack of schedule reliability. Those who have been late for work or an important appointment or have stood out in the rain or snow are unlikely to be repeat transit users. For travelers who must transfer between buses the potential for missing a connection becomes a major point of concern. While annoying to any passenger, a missed connection can be critical for a disabled passenger, especially in adverse weather conditions. Yet in the best of systems, schedule adherence is difficult given traffic, road construction, or unexpected problems with vehicle maintenance. When the required transfers are between different types of travel modes or different types of transportation services, a precise transfer becomes even more difficult. One promising approach to facilitating the critical transfer is the use of Automatic Vehicle Locator Systems (AVL). The current study will contribute to the discussion regarding applicability of AVL, specifically Global Positioning Systems (GPS), by addressing the following: 1. the application of AVL to a smaller transit operation than is usually studied ; 2. the potential for using AVL to effect transfers between fixed-route and paratransit vehicles; 3. the modifications required to adapt AVL for paratransit in rural areas.
Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling (2017)

The ability to differentiate human pluripotent stem cells (hPSCs) into cardiomyocytes (CMs) makes them an attractive source for repairing injured myocardium, disease modeling, and drug testing. Although current differentiation protocols yield hPSC-CMs to >90% efficiency, hPSC-CMs exhibit immature characteristics. With the goal of overcoming this limitation, we tested the effects of varying passive stretch on engineered heart muscle (EHM) structural and functional maturation, guided by computational modeling. Human embryonic stem cells (hESCs, H7 line) or human induced pluripotent stem cells (IMR-90 line) were differentiated to hPSC-derived cardiomyocytes (hPSC-CMs) in vitro using a small molecule based protocol. hPSC-CMs were characterized by troponin<sup>+</sup> flow cytometry as well as electrophysiological measurements. Afterwards, 1.2 × 10<sup>6</sup> hPSC-CMs were mixed with 0.4 × 10<sup>6</sup> human fibroblasts (IMR-90 line) (3:1 ratio) and type-I collagen. The blend was cast into custom-made 12-mm long polydimethylsiloxane reservoirs to vary nominal passive stretch of EHMs to 5, 7, or 9 mm. EHM characteristics were monitored for up to 50 days, with EHMs having a passive stretch of 7 mm giving the most consistent formation. Based on our initial macroscopic observations of EHM formation, we created a computational model that predicts the stress distribution throughout EHMs, which is a function of cellular composition, cellular ratio, and geometry. Based on this predictive modeling, we show cell alignment by immunohistochemistry and coordinated calcium waves by calcium imaging. Furthermore, coordinated calcium waves and mechanical contractions were apparent throughout entire EHMs. The stiffness and active forces of hPSC-derived EHMs are comparable with rat neonatal cardiomyocyte-derived EHMs. Three-dimensional EHMs display increased expression of mature cardiomyocyte genes including sarcomeric protein troponin-T, calcium and potassium ion channels, β-adrenergic receptors, and t-tubule protein caveolin-3. Passive stretch affects the structural and functional maturation of EHMs. Based on our predictive computational modeling, we show how to optimize cell alignment and calcium dynamics within EHMs. These findings provide a basis for the rational design of EHMs, which enables future scale-up productions for clinical use in cardiovascular tissue engineering. Stem Cells 2018;36:265-277.
Surfactant Self-Assemblies Controlling Spontaneous Dewetting (2002)

We have examined the structures of surfactant self-assemblies left on substrates as a contact line spontaneously retreats across the surface during an autophobing event. A continuous structural gradient is formed during the spontaneous retreat: from molecules lying down on the surface with low packing densities in a region never touched by the solution, to molecules standing up with higher packing densities in a region where the contact line has moved slowly. Despite significant free volumes within the self-assemblies, there is no evidence of clustering of molecules. We have observed a clear correlation between retreating contact line speeds and deposited surfactant structures. The dynamics during at least a later period of the autophobing event is dominated by the time evolution of Young's force dictated by the self-assembly near the contact line.
飄泊的身體與正義的僭越——讀〈身體倫理醫學模式對生物－心理－社會醫學模式的“僭越”〉 (2015)

LANGUAGE NOTE | Document text in Chinese; abstract in English only.Dr. Sun’s paper discusses the multiple meanings of the human body. It provides useful philosophical reflections on medical objectivism and reductionism. This commentary echoes and expands the rich connotations of the human body laid out in Sun’s paper. It also reveals and explores the transcendent dimension of the human body, contending that the unsacred materialization of the body is the crucial point of reductionism. In classical Chinese doctrines, the “body” has a unique social and spiritual existence, and the cultivation of the body is the fulfillment or perfection of a whole person that by no means can be reduced to dead or mechanical matter.DOWNLOAD HISTORY | This article has been downloaded 56 times in Digital Commons before migrating into this platform.
Phytochemical And Antidiabetic Studies On Methanolic Extract Of Corn Silk (2009)

Dried powder of corn silk was exhaustively extracted with methanol and the residue weighed. The chemical classes of constituents present in the extract were confirmed to be saponins, triterpenes, flavonoids, tannins, pseudo-tannins, alkaloids, volatile oils and glycosides. The LD50 of the extract was determined intraperitoneally in mice to be 3464.10 mg/kg. The blood sugar lowering effect of the extract was investigated in normal and alloxan induced diabetic rats. Glibenclamide treated animals were used as a positive control. The extract reduced the blood sugar levels of normal and alloxan induced diabetic rats. The reduction was more in alloxan induced diabetic rats than in normal rats. The reduction of the blood sugar level by the extract was comparable to that of glibenclamide. Reduction of the blood sugar levels by the extract in the alloxan induced diabetic rats lasted for 9 hours, the extract can be dosed twice a day. The extract is safe and even exhibited a comparable activity with that of glibenclamide; there is need for further work on corn silk for proper standardizations. Keywords: Corn silk, Acute toxicity, Phytocompounds, Antidiabetic, Methanolic extractPlant Product Research Journal Vol. 11 2007: pp. 16-18
Microtubule-binding domain of tau proteins. (1988)

Limited chymotryptic digestion of whole tau proteins produced a fragment of Mr 14,000 (CT14), which was able to bind to microtubules reconstituted from tubulin alone in the presence of taxol. This fragment was also found to persist in microtubules when microtubules consisting of tau proteins and tubulin were digested by chymotrypsin. Analysis of amino acid composition revealed that CT14 was rich in lysine and proline residues, suggesting unique structure of microtubule-binding domain of tau proteins. Amino-terminal sequence of CT14 was determined to be Ser-Ser-Pro-Gly-Ser-Pro-Gly-Thr-Pro-Gly-Ser-Arg-Ser-Arg-X-Pro-Ser-Leu-Pr o. No heterogeneity was detected in this amino-terminal sequence of 19 residues. Five species of polypeptides consisting of tau proteins were separated from each other by gel electrophoresis and subjected to chymotryptic digestion. CT14 was produced from each of the tau polypeptides by chymotryptic digestion, indicating that all tau polypeptides have a common microtubule-binding domain.
Determination of trace elements in zinc plant electrolyte by differential pulse polarography and anodic stripping voltammetry (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of trace elements in zinc plant electrolyte by differential pulse polarography and anodic stripping voltammetryEdwin S. Pilkington, Christopher. Weeks, and Alan M. BondCite this: Anal. Chem. 1976, 48, 12, 1665–1669Publication Date (Print):October 1, 1976Publication History Published online1 May 2002Published inissue 1 October 1976https://pubs.acs.org/doi/10.1021/ac50006a010https://doi.org/10.1021/ac50006a010research-articleACS PublicationsRequest reuse permissionsArticle Views163Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Selection and Directed Evolution of New Microbial Biocatalysts and Their Application to Organic Synthesis (2000)

As a typical example of the screening for a microbial biocatalyst from nature, isolation of nitrile-synthesizing microorganisms, characterization of a new enzyme aldoxime dehydratase, and its function in the aldoxime-nitrite pathway are introduced. Catalytic properties of some of our enzymes were improved through a direct evolutionary approach.
Medium noise mechanisms: Part 2 – Particulate noise (1994)

The fundamental noise in magnetic recording is due to the granularity of the medium. If amplitude as well as phase modulation noise sources are not present, particulate noise remains. This noise can exhibit a different character in tapes than in thin films, because thin films have strong magnetic interactions and are densely packed. Nonetheless, particulate noise is basic to all recording media. The structure of this chapter will be to discuss first granularity noise neglecting particle correlations. The total noise power is simply a sum of the independent noise power from each particle or grain. Next, correlation effects are discussed that can involve spatial as well as magnetic correlations. A general formalism will be given, but only simple examples will be examined. The difficulty is that particulate noise modeling is based on Poisson statistics, which are valid only for point or infinitesimally small particles. The effects of finite particle size for moderately dilute systems, which leads to non-overlap effects, can only be included approximately. Granularity noise in thin films, where the grains are tightly packed, must be analyzed differently. A simple approach will be discussed in Chapter 12. In this chapter signal-tonoise ratios are estimated, and wherever appropriate, comparison will be made with the results for continuum fluctuations calculated in Chapter 10. The chapter begins with a calculation of the replay voltage pulse and spectrum of a single particle following previous analyses (Thurlings, 1980, 1983; Arratia & Bertram, 1984). A simplified model of particle clustering is presented at the end of this chapter. Only stationary correlations are discussed in this chapter. Non-stationary effects are the focus of Chapter 12.
Development of Maskless-Curing Slurry Stereolithography for Fabricating High Strength Ceramic Parts (2014)

The aim of this study is to develop a novel maskless-curing slurry stereolithograhy and sintering process which can fabricate high strength ceramic parts. Three dimension printing of additive manufacturing method was used. High performance stereolithography slurry, which was composed of zirconia powder as structure material and methanol as a solvent and a dispersant, could be prepared with colloidal processing. During layer casting, the diaphanous slurry can penetrate into pores of the subjacent layers. After drying, the binder in the penetrated liquid could connect the fresh layer and subjacent layers. Eventually, a gel-like green block could be built layer by layer. In the exposed region, the resin contained in the green block was cured to connect the zirconia powders to be a part of the rigid green part. The obtained rigid green part was then heated up to 300°C for binder burnout, and then sintered at 1350°C to obtain a high dense zirconia ceramic part. The proposed method of maskless-curing slurry was briefly described and it was proved that the good capacity of solidifying thin layer.