gebhart/patrepeval huggingface dataset:
Efficacy of a novel mucolytic agent on pseudomyxoma peritonei mucin, with potential for treatment through peritoneal catheters. (2014)

Compared to current treatment for pseudomyxoma peritonei (PMP), the extraction of solubilised mucin through peritoneal catheter can be minimally invasive. However, mucin has variable appearance that may influence mucolysis. Hence, we investigated the mucolysis of 36 mucin samples with a novel agent. Using visual inspection and hardness index, PMP mucin was classified into three grades. The mucin pathological category was identified from patient record. Subsequently, the dissolution of the samples was tested. For in vitro, 1 g of mucin was treated to the mucolytic agent in 10 ml TRIS buffer at 37 deg. Celsius for 3 hours, with weighing of residual mucin. Control treatment was similar but received TRIS buffer. For in vivo, 2 g of implanted intra-peritoneal mucin in nude rats was treated to mucolytic (2 X 500 ul/24 hr, over 48 hours, plus another treatment before sacrifice at 56 hours, with weighing of residual mucin. Controls were treated but only with TRIS buffer. Six animals were used for each mucin grade (3 mucolytic treated & and 3 controls). Grades of mucin were soft mucin (62%), semi hard (20%) and hard mucin (18%). Diffuse peritoneal adenomucinosis had 50% of soft mucin and peritoneal mucinous carcinoma had 11% (P = 0.0382). In vitro and in vivo absolute disintegration was 100% for soft, 57.38% and 48.67% for semi hard, 50% and 28.67% for hard mucin. Majority of mucin were soft with complete disintegration, the rest showed variable disintegration, suggesting that the mucolytic has potential for treating PMP.
Organoboron Compounds. II. The Reducing Action of Some Organoboronic Acids<sup>1</sup> (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganoboron Compounds. II. The Reducing Action of Some Organoboronic Acids1John R. Johnson, M. G. Van Campen Jr., and Oliver GrummittCite this: J. Am. Chem. Soc. 1938, 60, 1, 111–115Publication Date (Print):January 1, 1938Publication History Published online1 May 2002Published inissue 1 January 1938https://pubs.acs.org/doi/10.1021/ja01268a034https://doi.org/10.1021/ja01268a034research-articleACS PublicationsRequest reuse permissionsArticle Views912Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Recombinant Human Interferon-  B/D Hybrid with a Broad Host-range (1987)

A recombinant interferon (IFN) hybrid has been found to have a broad host-range of activity in an antiviral assay (plaque reduction of vesicular stomatitis virus) and also high efficacy as an antiviral agent in at least 12 different animal cell species. The IFN hybrid consists of amino acids 1 to 60 from HuIFN-alpha B and amino acids 61 to 166 from HuIFN-alpha D. The profile of cross-species activity of the IFN-alpha B/D hybrid has been compared with that of HuIFN-alpha F, and of the parents HuIFN-alpha B and -alpha D. When both IFN-alpha B and -alpha D were active in a cell species, the hybrid IFN had comparable or better activity than the more active parental IFN. The hybrid shared a broad cross-species activity with IFN-alpha D. However, the IFN-alpha B/D hybrid was 10-fold more active on human cells, 30-fold more active on rabbit cells, and 50-fold more active on mouse cells than IFN-alpha D.
Gel-Based Mass Spectrometric Analysis of Recombinant GABA<sub>A</sub>Receptor Subunits Representing Strongly Hydrophobic Transmembrane Proteins (2008)

GABA(A) receptors are the major inhibitory transmitter receptors in mammalian brain and are composed of several protein subunits that can belong to different subunit classes, leading to enormous heterogeneity. To establish techniques for the analysis of GABA(A) receptors in complex mixtures such as brain tissue, recombinant receptors composed of alpha1 and His-tagged beta3 subunits expressed in insect cells were purified by affinity chromatography and run on blue native gels. After denaturing, receptors were subjected to one- or two-dimensional electrophoresis in SDS-gels. Proteins were cleaved by multienzyme proteolysis and subjected to nano-ESI-LC-MS/MS. Both GABA(A) receptor subunits were well-separated and unambiguously identified by sequence coverage of 99.1% (alpha1) and 92.9% (beta3).
Sequencing and model structure of a <i>Naja naja atra</i> protein fragment (2000)

We report the amino acid sequence of a basic protein isolated from the snake venom of Naja naja atra. An automated Edman sequencer was used to determine the 65-residue sequence, aided by electrospray ionization/mass spectrometry. Online reduction and pyridylethylation of the peptide was performed to identify the cysteine residues. Trypsin, chymotrypsin and aspartic digestions were carried out to derive peptide fragments for further sequencing. Fragmented peptides were overlapped to obtain the complete sequence. Molecular mass measurements of the whole protein and its fragments were used as a countercheck for sequence assignment. Further confirmation of the sequence was indicated by sequence homology to other snake venom neurotoxins. A molecular model of the tertiary structure was constructed based on sequence homology, and was refined by global minimization and extensive quality control algorithms. Electrostatic and hydrophobic surface calculations and molecular dynamics simulations were carried out to determine the functional properties of the molecule.
Influence of the Ta migration on dielectric properties of anodized Al‐Ta(N)‐Al trilayered oxide films (1989)

Abstract A trilayered dielectric thin‐film capacitor with an A1‐A1 2 O 3 ‐Ta 2 O 5 (N)‐A1 2 O 3 ‐A1 structure was formed by anodizing a trilayered thin‐film, A1‐Ta(N)‐A1, deposited by RF diode sputtering. During the anodization procedure, Ta migrates into the aluminum oxide layer. The effect of Ta migration on the stoichiometry of the aluminum oxide was investigated by AES/XPS analysis before and after heat treatment. The results of the analysis showed that the migrated Ta's were in metallic and oxide states. However, the majority of the migrated Ta was in the metallic state, while the majority of A1 was in an oxide state. When the sample was heat treated in air at 300°C, oxidization of A1 progressed, but Ta tended to be reduced. Therefore, when a capacitor with a thick Ta film is heat treated, tanδ increases. If the thickness of the Ta layer is chosen properly, the stoichiometry of the A1‐oxide improves, resulting in a low tanδ (tanδ = 0.0018).
Nutritional Studies on an Aphidophagous Chrysopid, Chrysopa septempunctata WESMAEL(Neuroptera:Chrysopidae) : III. Vitamin Requirement for Larval Development (1993)

Vitamin requirements of Chrysopa septempunctata were investigated using chemically-defined diets. A vitamin mixture containing 17 vitamins sustained larval development. When all the vitamins were removed from the diet, all larvae died in several days. An increase in the amount of vitamins in the mixture did not improve development. Choline chloride, nicotinic acid and Ca-pantothenate are essential for larval development. Omission of thiamine, riboflavin and folic acid also reduced the emergence ratio and prolonged the developmental period in the first generation. The requirements for other water-soluble vitamins are relatively low but some deterioration appeared in successive generations. No necessity for fat-soluble vitamins was observed over three generations. Further effects of carotenoid deficiency on photoperiodic induction of diapause were not recognized in several generations.
An approach to achieving multi-user integrity in a knowledge base system (2003)

The implementation of security results in a user being restricted to a subset of a knowledge base. The information content of constraints may mean that a user is not permitted to access some constraints. But without access permission to all constraints, a user may make modifications which do not satisfy the integrity of other users in the knowledge base system. The author describes an approach which shows how users who have access to a subset of the knowledge base which does not satisfy all constraints can act to restore their subset to a state where the information satisfies all integrity constraints. The user may make modifications to restore integrity, may place information in a pending state, or may work with unaffected areas of the knowledge base.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Influence of gangliosides on primary and metastatic neoplastic growth in human and murine cells. (1987)

The influence of gangliosides on tumor growth and frequency of metastasis in vivo as well as on growth and motility of neoplastic cells in vitro was tested utilizing human and rodent cell populations. In mice receiving injections of a ganglioside mixture twice daily the tumor volume, the number of spontaneous metastases per animal, and the number of mice with metastasis was approximately double that of controls. Preincubation of neoplastic cells with the ganglioside mixture doubled the number of metastatic foci in the lungs of mice receiving the cells by i.v. injection. Addition of a ganglioside mixture to the culture medium enhanced motility of neoplastic cells about 3-fold. This finding was similar to that observed for capillary endothelium. The presence of gangliosides in the culture media for a 48-h incubation period about doubled the number of neoplastic cells as compared to controls; the same was observed for capillary endothelium. The data are interpreted to indicate that gangliosides improve growth and mobilization of capillary endothelium and neoplastic cells. Both events may concur in enhancing tumor growth in vivo, the first by improving angiogenesis, the second by direct action on the neoplastic cell population.
The Determination of Unsubstituted Acid Amides<sup>1</sup> (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Determination of Unsubstituted Acid Amides1J. Mitchell Jr. and C. E. AshbyCite this: J. Am. Chem. Soc. 1945, 67, 2, 161–164Publication Date (Print):February 1, 1945Publication History Published online1 May 2002Published inissue 1 February 1945https://pubs.acs.org/doi/10.1021/ja01218a003https://doi.org/10.1021/ja01218a003research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Migration of home information system toward ISDN (1990)

The integrated services digital network (ISDN) residential service capabilities that can be accessed through the basic rate interface (BRI) are highlighted. Also presented is an ISDN home information system which would facilitate the evolving as well as developed home product standards. The author discusses wiring alternatives, home information system functional architecture and subsystems, and communication media available for use.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Use of the vertical reflectivity profile for identification of anomalous propagation (2001)

Abstract Anomalous propagation (anaprop), analogous to the upper mirage in the visual wavelengths, is still a major problem in radar meteorology. This phenomenon assumes particular importance in automatic recognition and estimation of rainfall. Anaprop echoes from terrain features such as hills and coasts often give echoes up to 50–60 dBZ, equivalent to heavy rain or hail in severe thunderstorms. Anaprop echoes from sea waves may be comparable in strength to those from moderate precipitation and also form similar patterns. Based on the evidence that the vertical reflectivity profile of precipitation is quite different from the anaprop profile, two methods for anaprop identification are presented. The method proposed by the Servizio Meteorologico Regionale (SMR, Italy) simply uses the operational scan procedure to discriminate between precipitation and anaprop. At the Swedish Meteorological and Hydrological Institute an ‘ad hoc’ scan strategy has been developed in order to obtain much more detail of the lowest reflectivity profile. A number of statistical parameters have been used to achieve a better discrimination between precipitation, land and sea clutter. A number of case studies, representing different echo intensities and patterns, and including a case of anaprop with embedded precipitation, are presented to assess the impact of these methods. Copyright © 2001 Royal Meteorological Society
Role of food allergy in atopic dermatitis (2004)

Food-induced eczema should be diagnosed only by a thorough diagnostic procedure, taking into account the patient's history, the degree of sensitization and the clinical relevance of the sensitization. More clinical and immunological studies are needed to unravel the pathophysiology and the different rates of clinical responsiveness to different foodstuffs in patients with atopic dermatitis.
Cryogenic Probe Station for Use in Automated Microwave and Noise Figure Measurements (1994)

A cryogenic measurement system capable of performing on-wafer RF testing of semiconductor devices and circuits has been developed. This "CryoProbe Station" can wafer probe devices and circuits at cryogenic temperatures, thus eliminating the need for wire bonds. The system operates under vacuum created by a sorption pump. It uses an open cycle cooling system that can be cooled with either liquid nitrogen or liquid helium. Presently, it can reach temperatures, as low as 80K and 37K for each of the coolants, respectively. The temperature can be raised using a heater and it is stabilized to within 0.2K by use of a temperature controller. The CryoProbe Station features a 1 by 2 inch stage that can hold large circuits and calibration standards simultaneously. The system is used with a Hewlett Packard 8510C Automatic Network Analyzer (ANA) to obtain S-parameter data over the frequency range 0.045-26.5 GHz. S-parameter data on HEMT (high electron mobility transistors) devices has been obtained with this station. With the use of DEEMBED software from NIST, detailed transmission line studies have been performed. Although the CryoProbe Station is designed for frequencies up to 26.5 GHz, useful transmission line data has been obtained for frequencies as high as 40 GHz. The CryoProbe station has also been used with the ATN noise figure measurement system to perform automatic, temperature dependent noise figure measurements.
Enhancing server availability and security through failure-oblivious computing (2004)

Abstract We present a new technique, failure-oblivious comput-ing, that enables servers to execute through memory errors without memory corruption. Our safe compiler forC inserts checks that dynamically detect invalid memory accesses. Instead of terminating or throwing an excep-tion, the generated code simply discards invalid writes and manufactures values to return for invalid reads, en-abling the server to continue its normal execution path. We have applied failure-oblivious computing to aset of widely-used servers from the Linux-based opensource computing environment. Our results show thatour techniques 1) make these servers invulnerable to known security attacks that exploit memory errors, and2) enable the servers to continue to operate successfully to service legitimate requests and satisfy the needs oftheir users even after attacks trigger their memory errors.
Detection of small round structured viruses in shellfish by reverse transcription-PCR (1995)

We describe the application of a previously developed sample extraction procedure to the detection of small round structured viruses (SRSVs) in shellfish. Initial seeding experiments showed that PCR inhibitor removal and virus recoveries were comparable to those in previous studies with poliovirus. Shellfish from a range of sewage-contaminated sites were then tested for the presence of SRSVs by using broadly reactive PCR primers followed by Southern blotting with internal probe sites. Positive results were obtained from 5 of 31 field samples tested. Four of these positive samples were from highly polluted sites. PCR product sequence analysis confirmed their identity as SRSV and showed sequence diversity compared with virus controls, suggesting that the results were not a consequence of PCR cross-contamination. Finally, shellfish associated with four separate outbreaks of viral gastroenteritis were tested by PCR and Southern blot for the presence of SRSVs. All outbreak samples tested gave positive results. As far as we are aware, this is the first demonstration of the detection in environmentally contaminated shellfish of the SRSVs responsible for human gastroenteritis. This development may help contribute to the further development of public health controls for molluscan shellfish.
Targeting CD146 with a <sup>64</sup> Cu-labeled antibody enables in vivo immunoPET imaging of high-grade gliomas (2015)

Given the highly heterogeneous character of brain malignancies and the associated implication for its proper diagnosis and treatment, finding biomarkers that better characterize this disease from a molecular standpoint is imperative. In this study, we evaluated CD146 as a potential molecular target for diagnosis and targeted therapy of glioblastoma multiforme (GBM), the most common and lethal brain malignancy. YY146, an anti-CD146 monoclonal antibody, was generated and radiolabeled for noninvasive positron-emission tomography (PET) imaging of orthotopic GBM models. (64)Cu-labeled YY146 preferentially accumulated in the tumors of mice bearing U87MG xenografts, which allowed the acquisition of high-contrast PET images of small tumor nodules (∼ 2 mm). Additionally, we found that tumor uptake correlated with the levels of CD146 expression in a highly specific manner. We also explored the potential therapeutic effects of YY146 on the cancer stem cell (CSC) and epithelial-to-mesenchymal (EMT) properties of U87MG cells, demonstrating that YY146 can mitigate those aggressive phenotypes. Using YY146 as the primary antibody, we performed histological studies of World Health Organization (WHO) grades I through IV primary gliomas. The positive correlation found between CD146-positive staining and high tumor grade (χ(2) = 9.028; P = 0.029) concurred with the GBM data available in The Cancer Genome Atlas (TCGA) and validated the clinical value of YY146. In addition, we demonstrate that YY146 can be used to detect CD146 in various cancer cell lines and human resected tumor tissues of multiple other tumor types (gastric, ovarian, liver, and lung), indicating a broad applicability of YY146 in solid tumors.
Indoor Particulate Matter of Outdoor Origin:  Importance of Size-Dependent Removal Mechanisms (2001)

Adverse human health effects have been observed to correlate with levels of outdoor particulate matter (PM), even though most human exposure to PM of outdoor origin occurs indoors. In this study, we apply a model and empirical data to explore the indoor PM levels of outdoor origin for two major building types: offices and residences. Typical ventilation rates for each building type are obtained from the literature. Published data are combined with theoretical analyses to develop representative particle penetration coefficients, deposition loss rates, and ventilation-system filter efficiencies for a broad particle size range (i.e., 0.001-10 microm). We apply archetypal outdoor number, surface area, and mass PM size distributions for both urban and rural airsheds. We also use data on mass-weighted size distributions for specific chemical constituents of PM: sulfate and elemental carbon. Predictions of the size-resolved indoor proportion of outdoor particles (IPOP) for various conditions and ambient particle distributions are then computed. The IPOP depends strongly on the ambient particle size distribution, building type and operational parameters, and PM metric. We conclude that an accurate determination of exposure to particles of ambient origin requires explicit consideration of how removal processes in buildings vary with particle size.
Azimuthally resolved optical second-harmonic generation from hydrogen on nickel (111) (1988)

We report the first azimuthally resolved measurements of the effect of an adsorbed gas on optical second-harmonic generation (SHG) from a clean, well-ordered metal surface. The second-harmonic intensity from Ni(111) decreases rapidly upon hydrogen adsorption; however, the threefold symmetry with sample rotation about the surface normal is retained. The ${\ensuremath{\beta}}_{1}$ and ${\ensuremath{\beta}}_{2}$ adsorption states are clearly resolved and their contributions to the second-order susceptibility are determined. For this system, SHG is highly sensitive to local site symmetry and little affected by long-range ordering of adsorbates.
Consumer Perceptions of Kosher Products (2002)

ABSTRACT The demand for kosher food has grown markedly during recent years, largely due to their perception as healthier, “safer,” more nutritionally enhanced value, and improved hygienic preparation conditions. This perception was verified by a survey conducted in Israel with 440 respondents. Both groups, younger and older age, secular and religious people, perceive the term kosher in a beneficial light, affecting the public view of food products as well as fast-food outlets. The survey, which was conducted in Israel, could be utilized as a pilot furnishing and facilitate a basis for further studies in other countries. The data highlights the vast market potential entailed in improving consumer perception of overall quality. Given the elevated perceived image of kosher food as “healthier” and of an enhanced quality, this study provides an essential marketing tool and detailed information in order to enable both manufacturers and retailers to expand the kosher segment and corner a larger share of the food market.