gebhart/patrepeval huggingface dataset:
SPLENIC CLEARANCE MECHANISMS OF REHYDRATED, LYOPHILIZED PLATELETS (2001)

A variety of platelet substitutes (e.g., rehydrated, lyophilized (RL) platelets, thromboerythrocytes, plateletsomes, infusible platelet membranes, synthocytes, fibrinogen-coated microcapules) are potentially useful as hemostatic agents in transfusion medicine. However, as "foreign" particles, platelet substitutes interact to varying extents with elements of the reticulo-endothelial system for clearance, reducing hemostatic efficacy. Experiments were performed to better understand the interaction of RL platelets with elements of the innate and acquired immune systems. The infusion of heterologous RL platelets into rats resulted in rapid clearance from the free circulation with half-life values of minutes. The clearance of RL platelets was inhibited when macrophages were rendered apoptotic with gadolinium. Transmission EM analysis of splenic tissue after infusion of lyophilized cells, as well as in vitro mixing studies with splenic macrophages and RL platelets, indicated that macrophage-mediated phagocytosis mechanisms were operant in RL platelet clearance by the reticulo-endothelial system. Studies with IV IgG, as a competitive inhibitor of the macrophage Fc receptor, provides evidence that RL platelet destruction is in part mediated by platelet surface bound IgG. This hypothesis was further supported by the finding that RL platelets react with IgG class antibodies that are pre-existing in naïve animals. These studies provide a rational basis for prolonging the circulation time of RL platelets and other platelet substitutes.
High-Intensity Focused Ultrasound in the Treatment of Experimental Liver Cancer (1991)

High-intensity focused ultrasound (HIFU) was used to treat Morris rat hepatoma 3924A implanted in the liver. Treatment was administered with a lens-focused 4-MHz transducer that created a focused beam of 550 W/cm2 at peak intensity. One hundred twelve rats with liver tumors were divided into two groups of 56 each. Group 1 received HIFU therapy while group 2 (the control group) did not. All rats were killed immediately or 1, 3, 7, 14, 21, or 28 days after treatment. Eight rats in each group were killed at each interval for pathologic and biochemical studies. Significant inhibition of the tumor growth was seen in the HIFU-treated group, with tumor growth inhibition rates of 65.4% to 93.1% from the third to the 28th day after treatment. Ultrasound-treated tumors showed direct thermal cytotoxic necrosis and fibrosis. An additional 56 ACl rats with liver tumors were divided into four groups of 14 each. Group 1 received doxorubicin hydrochloride intraperitoneally and HIFU therapy; group 2, HIFU therapy; group 3, doxorubicin hydrochloride; and group 4 (the control group), neither HIFU nor doxorubicin hydrochloride. Significantly improved survival rates were noted in HIFU-treated animals (groups 1 and 2) compared with those of groups 3 and 4. These data suggest that HIFU may be a useful method for local treatment of hepatic tumors.
A low-complexity sub-Nyquist sampling system for wideband Radar ESM receivers (2014)

The problem of efficient sampling of wideband Radar signals for Electronic Support Measures (ESM) is investigated in this paper. Wideband radio frequency sampling generally needs a sampling rate at least twice the maximum frequency of the signal, i.e. Nyquist rate, which is generally very high. However, when the signal is highly structured, like wideband Radar signals, we can use the fact that signals do not occupy the whole spectrum and instead, there exists a parsimonious structure in the time-frequency domain. Here, we use this fact and introduce a novel low complexity sampling system, which has a recovery guarantee, assuming that received RF signals follow a particular structure. The proposed technique is inspired by the compressive sampling of sparse signals and it uses a multi-coset sampling setting, however it does not involve a computationally expensive reconstruction step. We call this here Low-Complexity Multi-Coset (LoCoMC) sampling technique. Simulation results, show that the proposed sub-Nyquist sampling technique works well in simulated ES scenarios.
Black Box Testing: Techniques for Functional Testing of Software and Systems (1996)

Graphs and Relations. Control-Flow Testing. Loop Testing. Data-Flow Testing. Transaction-Flow Testing. Domain Testing. Syntax Testing. Finite-State Testing. Tools and Automation. Appendix. Cited References and Bibliography. Index.
Spin moment of a thrust ball bearing in traction fluid. (1990)

A thrust ball bearing lubricated in traction fluid has larger spin moment than a bearing lubricated in turbine oil. This is because the rheological characteristics of the traction fluid's limiting shear stress increase steeply when the contact pressure exceeds the glass transition pressure of 0.6∼1 GPa. The monent of the bearing sometimes causes a decrease in the mechanical efficiency of traction drive transmission. In this report, the monent is measured by a compact facility consisting of a hydraulic cylinder with load capacity of 50 kN and a rotational speed of 8000 rpm. The theoretical moment is estimated from the rheological model of elastoplastic fluid and the spin moment analysis of the contact area considering the flash temperature. As a result, it is clear that an equivalent friction coefficient of the thrust ball bearing of 58mm(PCD), curvature ratio of f0=0.52 (radius of race curvature divided by ball diameter) lubricated in traction fluid is about 0.030 instead of 0.0012 in turbine oil. It is predicted that the moment of the bearing of f0=0.60 will be halved.
A multiband /spl Delta//spl Sigma/ fractional-N frequency synthesizer for a MIMO WLAN transceiver RFIC (2005)

This work presents a shared fractional-N synthesizer used by two dual-band 802.11 radios integrated on a single chip for 2/spl times/2 multiple-input multiple-output (MIMO) applications. Additional 2/spl times/2 MIMO chips can be used in a system by phase synchronizing the signal paths through a bidirectional LO porting scheme developed for this application. This synthesizer was fully integrated with the exception of an off-chip loop filter. The synthesizer is a /spl Delta//spl Sigma/-based fractional-N frequency synthesizer with three on-chip LC tuned VCOs to cover the entire frequency bands specified in the IEEE 802.11a/b/g and Japanese WLAN standards. The radio uses a variable IF frequency so that both the RF LO and IF LO can be derived from a single synthesizer saving chip area and power. The synthesizer includes a programmable second/third-order /spl Delta//spl Sigma/ noise shaper, a phase frequency detector, a differential charge pump, and a 6-bit multimodulus divider (MMD). The nominal jitter from 100 Hz to 10 MHz is 0.63-0.86/spl deg/ rms in the 5-GHz band and 0.35-0.43/spl deg/ rms in the 2.4-GHz band. The maximum frequency deviation of the synthesizer when enabling the transmitter is less than 150 kHz and the frequency error settles to 2 kHz in less than 12 /spl mu/s. For MIMO applications requiring more than two full paths, a single synthesizer on one die can be used to generate the LOs for all other radios integrated in different dies.
Poly(ADP-ribose) polymerase-1 gene ablation protects mice from ischemic renal injury (2004)

Increased generation of reactive oxygen species (ROS) and the subsequent DNA damage and excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1) have been implicated in the pathogenesis of ischemic injury. We previously demonstrated that pharmacological inhibition of PARP protects against ischemic renal injury (IRI) in rats (Martin DR, Lewington AJ, Hammerman MR, and Padanilam BJ. Am J Physiol Regul Integr Comp Physiol 279: R1834-R1840, 2000). To further define the role of PARP-1 in IRI, we tested whether genetic ablation of PARP-1 attenuates tissue injury after renal ischemia. Twenty-four hours after reperfusion following 37 min of bilateral renal pedicle occlusion, the effects of the injury on renal functions in PARP-/- and PARP+/+ mice were assessed by determining glomerular filtration rate (GFR) and the plasma levels of creatinine. The levels of plasma creatinine were decreased and GFR was augmented in PARP-/- mice. Morphological evaluation of the kidney tissues showed that the extent of damage due to the injury in PARP-/- mice was less compared with their wild-type counterparts. The levels of ROS and DNA damage were comparable in the injured kidneys of PARP+/+ and PARP-/- mice. PARP activity was induced in ischemic kidneys of PARP+/+ mice at 6-24 h postinjury. At 6, 12, and 24 h after injury, ATP levels in the PARP+/+ mice kidney declined to 28, 26, and 43%, respectively, whereas it was preserved close to normal levels in PARP-/- mice. The inflammatory cascade was attenuated in PARP-/- mice as evidenced by decreased neutrophil infiltration and attenuated expression of inflammatory molecules such as TNF-alpha, IL-1beta, and intercellular adhesion molecule-1. At 12 h postinjury, no apoptotic cell death was observed in PARP-/- mice kidneys. However, by 24 h postinjury, a comparable number of cells underwent apoptosis in both PARP-/- and PARP+/+ mice kidneys. Thus activation of PARP post-IRI contributes to cell death most likely by ATP depletion and augmentation of the inflammatory cascade in the mouse model. PARP ablation preserved ATP levels, renal functions, and attenuated inflammatory response in the setting of IRI in the mouse model. PARP inhibition may have clinical efficacy in preventing the progression of acute renal failure complications.
Combined Biochemical and Electron Microscopic Analyses Reveal the Architecture of the Mammalian U2 snRNP (1999)

The 17S U2 small nuclear ribonucleoprotein particle (snRNP) represents the active form of U2 snRNP that binds to the pre-mRNA during spliceosome assembly. This particle forms by sequential interactions of splicing factors SF3b and SF3a with the 12S U2 snRNP. We have purified SF3b and the 15S U2 snRNP, an intermediate in the assembly pathway, from HeLa cell nuclear extracts and show that SF3b consists of four subunits of 49, 130, 145, and 155 kD. Biochemical analysis indicates that both SF3b and the 12S U2 snRNP are required for the incorporation of SF3a into the 17S U2 snRNP. Nuclease protection studies demonstrate interactions of SF3b with the 5' half of U2 small nuclear RNA, whereas SF3a associates with the 3' portion of the U2 snRNP and possibly also interacts with SF3b. Electron microscopy of the 15S U2 snRNP shows that it consists of two domains in which the characteristic features of isolated SF3b and the 12S U2 snRNP are conserved. Comparison to the two-domain structure of the 17S U2 snRNP corroborates the biochemical results in that binding of SF3a contributes to an increase in size of the 12S U2 domain and possibly induces a structural change in the SF3b domain.
论约翰·罗尔斯的《正义论》:经验运用正义论的一个尝试 (1991)

引言约翰·罗尔斯的《正义论》(1971年)引起了学界的巨大兴趣,这一点可以近年来出现的许多论述这部巨作的书和文章来作证。该书是用经济学家特别熟悉的范畴写的,因而很适合作经验的运用,本文即拟运用《正义论》提出的差别原则。在第一部分中,我将首先研究著作本身特别是书中提出的差别原则,然后评论某些作家对这一原则的批评意见。第二部分将真正试图运用差别原则。最后,第三部分将考虑第一部分中
Dynamic EGR Estimation for Production Engine Control (2001)

<div class="htmlview paragraph">A dynamic EGR State Estimator (ESE) intended for production engine management systems (EMS) implementation is presented. It better describes the development of external exhaust gas recirculation (EGR) concentration at the engine intake ports during EGR transients than traditional models. The dynamics of EGR concentration time and spatial development in the intake manifold are described as a perfect mixing model in the intake manifold plenum volume and non-mixing plug flow in the intake manifold runners. The time scale of EGR transients precludes the use of traditional EGR measurement techniques for model verification. Instead a wide range air fuel (WRAF) sensor is used. Results are shown for a large variation in operating conditions and compared to the performance of a traditional model. The introduction of an exhaust inert ratio model converts the EGR estimate into the inert EGR concentration, the distinction between total and inert EGR concentration being of relevance for lean operating engines.</div>
The use of molecular-replacement phases for the refinement of the human rhinovirus 14 structure (1988)

The structure of human rhinovirus 14 has been refined, by the method of restrained least squares, to an R factor of 0.16 for various random samples between 6 and 3 A resolution with F greater than 3 sigma (F). As a first step the non-crystallographic symmetry parameters were optimized using the initial atomic model in a rigid-body refinement procedure. Phase determination by the molecular-replacement phase extension and refinement procedure was continued to 2.94 A resolution, employing the improved non-crystallographic symmetry operators. The resultant structure-factor phases and weights, together with the measured amplitudes, constituted the X-ray observations used in the restrained refinement. The Hendrickson-Konnert program system [Konnert & Hendrickson (1980). Acta Cryst. A36, 344-350] was modified to incorporate non-crystallographic symmetry constrains and structure-factor phases as observations. The non-bonded contacts between subunits related by non-crystallographic symmetry were also restrained.
[Cell death protection by anti-apoptotic factor]. (2001)

Neurodegenerative disorders including ALS and Parkinson's disease are characterized by progressive loss of neuronal cell death. Apoptosis, a morphologically and biochemically defined form of cell death caused by active cellular signaling, has been long implicated in neurodegeneration. Recently, the basic molecular mechanism of apoptosis has been elucidated and a subset of cysteine proteases called caspases were shown to be the executioner of apoptosis. On the other hand, endogenous caspase inhibitor called inhibitor of apoptosis proteins (IAPs) were also identified. XIAP, the most potent apoptosis inhibitor among human IAPs, is shown to be direct and selective inhibitor for caspase-3, -7 and -9. We have very recently shown that XIAP has ubiquitin ligase activity which promotes the degradation of caspase-3 and this protease activity enhances the anti-apoptotic activity of XIAP. Regarding the involvement of apoptosis in neurodegenerative diseases, several lines of evidence indicated that caspases are involved in the pathogenesis of ALS and polyglutamine disease, suggesting the effectiveness of anti-apoptotic therapy for these diseases. Moreover, caspase-independent programmed cell death is also suggested to be involved in neurodegenerative disorders. Based on these findings, the therapeutic strategy for neurodegenerative disease should include both anti-apoptotic and anti-non-apoptotic cell death treatments.
Neural networks for nonlinear programming (1988)

The dynamics of the modified canonical nonlinear programming circuit are studied and how to guarantee the stability of the network's solution. By considering the total cocontent function, the solution of the canonical nonlinear programming circuit is reconciled with the problem being modeled. In addition, it is shown how the circuit can be realized using a neural network, thereby extending the results of D.W. Tank and J.J. Hopefield (ibid., vol.CAS-33, p.533-41, May 1986) to the general nonlinear programming problem.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Gini Coefficient:  A New Way To Express Selectivity of Kinase Inhibitors against a Family of Kinases (2007)

A novel application of the Gini coefficient for expressing selectivity of kinase inhibitors against a panel of kinases is proposed. This has been illustrated using single-point inhibition data for 40 commercially available kinase inhibitors screened against 85 kinases. Nonselective inhibitors are characterized by Gini values close to zero (Staurosporine, Gini 0.150). Highly selective compounds exhibit Gini values close to 1 (PD184352 Gini 0.905). The relative selectivity of inhibitors does not depend on the ATP concentration.
A Review of Deep Learning-Based Semantic Segmentation for Point Cloud (2019)

In recent years, the popularity of depth sensors and 3D scanners has led to a rapid development of 3D point clouds. Semantic segmentation of point cloud, as a key step in understanding 3D scenes, has attracted extensive attention of researchers. Recent advances in this topic are dominantly led by deep learning-based methods. In this paper, we provide a survey covering various aspects ranging from indirect segmentation to direct segmentation. Firstly, we review methods of indirect segmentation based on multi-views and voxel grids, as well as direct segmentation methods from different perspectives including point ordering, multi-scale, feature fusion and fusion of graph convolutional neural network (GCNN). Then, the common datasets for point cloud segmentation are exposed to help researchers choose which one is the most suitable for their tasks. Following that, we devote a part of the paper to analyze the quantitative results of these methods. Finally, the development trend of point cloud semantic segmentation technology is prospected.
Probing Liquid Crystals with Nonlinear Optical Processes (1987)

Abstract Nonlinear optical effects provide some unique opportunities to study certain properties and structures of liquid crystal system. Examples are presented here to illustrate the potential of such studies.
Structure and Transcription of the Human m3 Muscarinic Receptor Gene (2002)

We have isolated and characterized the human m3 muscarinic receptor gene and its promoter. Using 5' rapid amplification of cDNA ends (RACE), internal polymerase chain reaction (PCR), and homology searching to identify EST clones, we determined that the cDNA encoding the m3 receptor comprises 4,559 bp in 8 exons, which are alternatively spliced to exclude exons 2, 4, 6, and/or 7; the receptor coding sequence occurs within exon 8. Analysis of P1 artificial chromosome (PAC) and bacterial artificial chromosome (BAC) clones and of PCR- amplified genomic DNA, and homology searching of human chromosome 1 sequence provided from the Sanger Centre (Hinxton, Cambridge, UK) revealed that the m3 muscarinic receptor gene spans at least 285 kb. A promoter fragment containing bp -1240 to +101 (relative to the most 5' transcription start site) exhibited considerable transcriptional activity during transient transfection in cultured subconfluent, serum-fed canine tracheal myocytes, and 5' deletion analysis of promoter function revealed the presence of positive transcriptional regulatory elements between bp -526 and -269. Sequence analysis disclosed three potential AP-2 binding sites in this region; five more AP-2 consensus binding motifs occur between bp -269 and +101. Cotransfection with a plasmid expressing human AP-2alpha substantially increased transcription from m3 receptor promoter constructs containing 526 or 269 bp of 5' flanking DNA. Furthermore, m3 receptor promoter activity was enhanced by long-term serum deprivation of canine tracheal myocytes, a treatment that is known to increase AP-2 transcription-promoting activity in these cells. Together, these data suggest that expression of the human m3 muscarinic receptor gene is regulated in part by AP-2 in airway smooth muscle.
Lunar volcanism: Fracture patterns and rilles in marginal premare craters, part R (1972)

Probable causes, distributions, and nature of fracture patterns of Type 3 craters around the margins of major maria are investigated.
Problems in the scientific study of the teaching of arithmetic. (1913)

Compare problem 7 under cultural phases of the question."Certain phases of this problem seem at present impossible of exact solution.Methods and means of attack are lacking.Psychological aud statistical research have not yet developed sufficiently to make full investigation possible ; but it is none the less important that we face the question.'Compare last part of problem 4 under practical phases of the question.*Mucli good work has been done on this problem, but more is needed.
<title>Scanning silicon micromirror using a bidirectionally movable magnetic microactuator</title> (2000)

In this work, a scanning silicon micromirror using a bi- directionally movable magnetic microactuator is designed, fabricated and characterized. Although there have been technical difficulties in realizing bi-directional motion in magnetic MOEMS devices for the lack of a suitable structuring technique for permanent magnet components, we overcome those by using UV-LIGA process of thick CONiMnP alloy films and arrays. Based on this new fabrication technique, hard magnetic films or arrays are directly electroplated on silicon cantilever beams in order to compose moving mirror parts. A micromirror is constructed by combining the beam with an electromagnet. According to the change of current in electromagnets, the micromirrors are deflected either upward or downward depending on the direction of magnetic field generated by the electromagnets. Optical properties of the scanning mirrors are measured by a He-Ne laser beam source with the wavelength of 632.8 nm and an optical power detector. A prototype scanning micromirror shows +/- 60 micrometers deflections at the current of +/- 100 mA. The Gaussian profile of the laser beam is well preserved. The reflectance is above 98 percent for the mirrors coated with aluminum films.
Increased Stress-Induced Inflammatory Responses in Male Patients With Major Depression and Increased Early Life Stress (2006)

Male major depression patients with increased early life stress exhibit enhanced inflammatory responsiveness to psychosocial stress, providing preliminary indication of a link between major depression, early life stress and adverse health outcomes in diseases associated with inflammation.
Dual-wavelength laser source for onboard atom interferometry (2011)

We present a compact and stable dual-wavelength laser source for onboard atom interferometry with two different atomic species. It is based on frequency-doubled telecom lasers locked on a femtosecond optical frequency comb. We take advantage of the maturity of fiber telecom technology to reduce the number of free-space optical components, which are intrinsically less stable, and to make the setup immune to vibrations and thermal fluctuations. The source provides the frequency agility and phase stability required for atom interferometry and can easily be adapted to other cold atom experiments. We have shown its robustness by achieving the first dual-species K-Rb magneto-optical trap in microgravity during parabolic flights.
Decreased tear lipocalin concentration in patients with meibomian gland dysfunction (2005)

These results suggest that TL deficiency may be a predisposing factor for the manifestation of symptoms in MGD.
Metastatic Renal Cell Carcinoma of the Sphenoid Sinus: Case Report (2008)

Introduction: Distant metastasis to the paranasal sinuses is rare. We report a case of metastatic renal cell carcinoma of the sphenoid sinus associated with metastasis to the choroid plexus of the lateral ventricle.
OBSERVATIONS ON THE CONTENT OF ATP AND ADP IN BULL SPERMATOZOA USING THE FIREFLY LUCIFERASE SYSTEM (1970)

The development of a method to measure small amounts of nucleotides would be of considerable value in experiments concerned with metabolism in mammalian spermatozoa. As the adenine nucleotides have been shown to be the predominant nucleotides in mammalian spermatozoa (Brooks, 1970), measurement of ATP and ADP by the luciferin-luciferase system appeared to be a method ideally suited to this purpose. Ejaculated bull semen, collected by artificial vagina, was used in the present work. The measurement of ATP was carried out in a Packard Model 3380 liquid scintillation spectrometer calibrated according to Stanley & Williams (1969). The phosphate buffer described by these workers was altered to include 2 mm-EDTA and 2 mm-2-mercaptoethanol. In addition, the luciferin-luciferase preparation made up in arsenate buffer was incubated with apyrase to reduce background luminescence