gebhart/patrepeval huggingface dataset:
The Architectural Implications of Facebook's DNN-based Personalized Recommendation (2019)

The widespread application of deep learning has changed the landscape of computation in the data center. In particular, personalized recommendation for content ranking is now largely accomplished leveraging deep neural networks. However, despite the importance of these models and the amount of compute cycles they consume, relatively little research attention has been devoted to systems for recommendation. To facilitate research and to advance the understanding of these workloads, this paper presents a set of real-world, production-scale DNNs for personalized recommendation coupled with relevant performance metrics for evaluation. In addition to releasing a set of open-source workloads, we conduct in-depth analysis that underpins future system design and optimization for at-scale recommendation: Inference latency varies by 60% across three Intel server generations, batching and co-location of inferences can drastically improve latency-bounded throughput, and the diverse composition of recommendation models leads to different optimization strategies.
The continuum of intestinal CD4<sup>+</sup>T cell adaptations in host-microbial mutualism (2011)

How a mutualistic relationship between the intestinal microbiota and intestinal T cell compartments is established is important, as a breakdown of intestinal T cell homeostasis may cause inflammatory bowel diseases. A number of studies have shown that different bacterial species modulate the intestinal CD4(+) T cell compartment in different ways. We performed mechanistic in vivo studies that demonstrated the crucial requirement for regulatory T cells (Treg) and interleukin-10 (IL-10) in the induction of intestinal T cell homeostasis even following colonization with a completely benign microbiota. In the absence of a functional Treg response or IL-10 receptor signaling, the same bacteria that induced a Treg response in wild-type animals now induced T helper type 17 responses, without intestinal inflammation. Therefore, Treg, IL-10 and Th17 are crucial regulatory mechanisms in the intestine not only for controlling inflammation, but also to establish a continuum of CD4(+) T cell homeostasis upon commensal colonization.
Structural characterization of the mesangial cell type IV collagenase and enhanced expression in a model of immune complex-mediated glomerulonephritis. (1992)

Secretion of glomerular cell-derived matrix metalloproteinases (MMPs) and their specific inhibitors, TIMP-1,2, may play an important role in the turnover of the glomerular extracellular matrix under basal and pathologic conditions. A 66-68 kd MMP secreted by cultured mesangial cells (MC) with activity against Type IV collagen and gelatin was purified and shown by amino-acid sequence analysis to be identical with a Type IV collagenase/gelatinase secreted by certain transformed tumor cell lines. The expression of the mesangial MMP in vivo was limited within the kidney to a small subset of the intrinsic glomerular mesangial cell population. After induction of acute anti-Thy 1.1 glomerulonephritis, there was a large increment in the number of Type IV collagenase-secreting MC, temporally coincident with the development of mesangial hypercellularity. The expression of the MMP inhibitor protein, TIMP-1, was not changed over this period. Ultrastructural studies localized the mesangial MMP to areas of evolving mesangiolysis and at sites of glomerular basement membrane disruption. Enhanced expression of the mesangial cell-derived Type IV collagenase may contribute to the evolution of glomerular injury in this model of immune complex-mediated glomerulonephritis or may be involved in the extensive matrix remodeling process that accompanies this form of glomerular injury.
Consumer electronics control system based on hand gesture moment invariants (2007)

Almost all consumer electronic equipment today uses remote controls for user interfaces. However, the variety of physical shapes and functional commands that each remote control features also raises numerous problems: the difficulties in locating the required remote control, the confusion with the button layout, the replacement issue and so on. The consumer electronics control system using hand gestures is a new innovative user interface that resolves the complications of using numerous remote controls for domestic appliances. Based on one unified set of hand gestures, this system interprets the user hand gestures into pre-defined commands to control one or many devices simultaneously. The system has been tested and verified under both incandescent and fluorescent lighting conditions. The experimental results are very encouraging as the system produces real-time responses and highly accurate recognition towards various gestures.
RADA‐16: A Tough Peptide – Strategies for Synthesis and Purification (2013)

Abstract The self‐assembling capacity of certain molecules can be exploited for a diverse range of biomedical applications. The ionic complementary peptide RADA‐16 is well‐known for its propensity to self‐assemble, which derives from its architectural arrangement. Herein, we describe rational synthetic strategies of synthesis of RADA‐16 based on fragment condensation, and its subsequent purification through optimized methods. Our methodology should prove suitable for the preparation of other peptides prone to self‐assembly.
Design of the fuzzy-PID controller for new vehicle active suspension with electro-hydrostatic actuator (2009)

A fuzzy-PID controller is designed for the new active suspension with Electro-Hydrostatic Actuator (EHA). The inputs of the fuzzy controller are displacement of the sprung mass relative to its static balance position (i.e. dynamic deflection) and its changing rate, while its outputs are proportional, integral and derivative gains of PID controller. The paper gives the fuzzy-PID controller's design process and key drive circuits. At the end of the paper, some test results are presented which show that active suspension with EHA using fuzzy-PID control is effective under road conditions with excitations of different frequencies, and that the vertical acceleration of vehicle body and the dynamic deflection of suspension are evidently reduced and that the ride comfort, handling and stability of vehicle are enhanced.
SOME EFFECTS OF WORT COMPOSITION ON THE RATE AND EXTENT OF FERMENTATION BY BREWING YEASTS (1972)

The time required to ferment worts of varied composition to a given extent is dependent upon the extent of exponential growth in the early stages of fermentation; in the worts studied this is determined by the concentration of assimilable nitrogen. When the concentration of all the non-carbohydrate nutrients in malt wort is halved by dilution with carbohydrate, the addition of appropriate quantities of serine or arginine restores the rate of fermentation to that of the malt wort. Minor nutrients, other than amino acids specifically required by the yeasts used, are thus present in at least two-fold excess in the malt wort. The yeast produced during exponential growth in malt wort (sp.gr. 1·040) is able to ferment rapidly much greater quantities of fermentable carbohydrate than are present in that wort. The majority of the strains of yeast examined ferment equally well when either glucose or maltose is added to malt wort and do so whether the sugar is added prior to fermentation or towards the end; however, one strain fails to ferment satisfactorily if a substantial quantity of glucose is added to wort prior to fermentation, because of the subsequent failure of the yeast to adapt to ferment maltose. It is suggested that most brewing strains do not require to adapt to maltose utilization during the fermentation of wort.
Pathogenetic Role of Gut in Irreversible Hemorrhagic Shock (1997)

In this article, we have attempted to address the pathogenetic role of the gut in irreversible of hemorrhagic shock. Hemorrhagic shock is a major cause of death in patients with trauma. Severe hemorrhagic shock can progress to an irreversible state leading to death even after circulation is restored, as first described by Wiggers Harold. Mechanisms for irreversible shock remain unclear, however, experimental data have strongly implicated a pathogenetic role for the gut in irreversible shock as supported by the following: (1) intestinal ischemia by itself provokes irreversible shock; and (2) removal of the intestines or avoidance of intestinal ischemia during shock protects animals from irreversibility. In the literature, irreversible shock has been attributed to a number of alterations observed in hemorrhagic shock animal models, including the depletion of hepatic adenosine triphosphate (ATP) levels. After the induction of hemorrhagic shock, many organs are associated with decreased ATP levels, but the liver, among the various organs studied, was noted to have its ATP reserves depleted the most dramatically and correlated most reliably with the decompensatory phase of shock. Recent studies have shown that the intestines are involved in the process leading to both the depletion of hepatic ATP and irreversible shock, suggesting a causal relationship between the gut-related energy insufficiency of the liver during hemorrhagic shock and the occurrence of irreversible shock. Continued research to investigate the intestinal effect on hepatic energy metabolism during hemorrhagic hypotension may help us better understand the mechanisms of irreversible hemorrhagic shock.
Long-Term Effects of Axotomy on Excitability and Growth of Isolated<i>Aplysia</i>Sensory Neurons in Cell Culture: Potential Role of cAMP (1998)

Crushing nerves, which contain the axons of central sensory neurons, in Aplysia causes the neurons to become hyperexcitable and to sprout new processes. Previous experiments that examined the effects of axonal injury on Aplysia sensory neurons have been performed in the intact animal or in the semi-intact CNS of Aplysia. It therefore has been unclear to what extent the long-term neuronal consequences of injury are due to intrinsic or extrinsic cellular signals. To determine whether injury-induced changes in Aplysia sensory neurons are due to intrinsic or extrinsic signals, we have developed an in vitro model of axonal injury. Isolated central sensory neurons grown for 2 days in cell culture were axotomized. Approximately 24 h after axotomy, sensory neurons exhibited a greater excitability-reflected, in part, as a significant reduction in spike accommodation-and greater neuritic outgrowth than did control (unaxotomized) neurons. Rp diastereoisomer of the cyclic adenosine 3',5'-monophosphorothiate (Rp-cAMPS), an inhibitor of protein kinase A, blocked both the reduction in accommodation and increased neuritic outgrowth induced by axotomy. Rp-cAMPS also blocked similar, albeit smaller, alterations observed in control sensory neurons during the 24-h period of our experiments. These results indicate that axonal injury elevates cAMP levels within Aplysia sensory neurons, and that this elevation is directly responsible, in part, for the previously described long-term electrophysiological and morphological changes induced in Aplysia sensory neurons by nerve crush. In addition, the results indicate that control sensory neurons in culture are also undergoing injury-related electrophysiological and structural changes, probably due to cellular processes triggered when the neurons are axotomized during cell culturing. Finally, the results provide support for the idea that the cellular processes activated within Aplysia sensory neurons by injury, and those activated during long-term behavioral sensitization, overlap significantly.
Reducing TDP-43 aggregation does not prevent its cytotoxicity (2013)

Our results suggest that TDP-43 aggregation is associated with the cell death process rather than being a direct cause.
The TimeGeo modeling framework for urban mobility without travel surveys (2016)

Well-established fine-scale urban mobility models today depend on detailed but cumbersome and expensive travel surveys for their calibration. Not much is known, however, about the set of mechanisms needed to generate complete mobility profiles if only using passive datasets with mostly sparse traces of individuals. In this study, we present a mechanistic modeling framework (TimeGeo) that effectively generates urban mobility patterns with resolution of 10 min and hundreds of meters. It ties together the inference of home and work activity locations from data, with the modeling of flexible activities (e.g., other) in space and time. The temporal choices are captured by only three features: the weekly home-based tour number, the dwell rate, and the burst rate. These combined generate for each individual: (i) stay duration of activities, (ii) number of visited locations per day, and (iii) daily mobility networks. These parameters capture how an individual deviates from the circadian rhythm of the population, and generate the wide spectrum of empirically observed mobility behaviors. The spatial choices of visited locations are modeled by a rank-based exploration and preferential return (r-EPR) mechanism that incorporates space in the EPR model. Finally, we show that a hierarchical multiplicative cascade method can measure the interaction between land use and generation of trips. In this way, urban structure is directly related to the observed distance of travels. This framework allows us to fully embrace the massive amount of individual data generated by information and communication technologies (ICTs) worldwide to comprehensively model urban mobility without travel surveys.
Migration of Endothelial Progenitor Cells Mediated by Stromal Cell-Derived Factor-1α/CXCR4 via PI3K/Akt/eNOS Signal Transduction Pathway (2007)

Stromal cell-derived factor (SDF)-1alpha, a member of the chemokine CXC subfamily, plays an important role in regulation of a variety of cellular functions of endothelial progenitor cells such as cell migration, proliferation, survival and angiogenesis. However, there is relatively little information linking the cellular functions and individual signaling pathways mediated by SDF-1alpha in endothelial progenitor cells. In our study, we showed that endothelial progenitor cells expressed CXCR4 by reverse transcription polymerase chain reaction and flow cytometric analysis. Functional analysis showed that SDF-1alpha induced a concentration-dependent migration of endothelial progenitor cells and the migration was CXCR4 dependent as confirmed by the total inhibition by AMD3100, a CXCR4-specific peptide antagonist. The migration can also be nearly completely blocked by phosphoinositide 3-kinase inhibitors (LY294002 and wortmannin) and eNOS inhibitor (N-nitro-arginine methyl ester), whereas mitogen-activated protein kinase/ERK inhibitor (PD98059) had no significant effect on SDF-1alpha-induced migration. The treatment of endothelial progenitor cells with SDF-1alpha resulted in time and concentration-dependent Akt, eNOS, and ERK1/2 phosphorylation. These findings suggested that phosphoinositide 3-kinase/Akt/eNOS, but not mitogen-activated protein kinase/ERK, signal transduction pathway may be involved in SDF-1alpha mediated migration of endothelial progenitor cells.
DNA Double-Strand Break Repair Genes and Oxidative Damage in Brain Metastasis of Breast Cancer (2014)

BARD1 and RAD51 are frequently overexpressed in brain metastases from breast cancer and may constitute a mechanism to overcome reactive oxygen species-mediated genotoxic stress in the metastatic brain.
Synthesis and biological activity of D-bishomosteroids (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and biological activity of D-bishomosteroidsGeorge Eadon and Carl DjerassiCite this: J. Med. Chem. 1972, 15, 1, 89–91Publication Date (Print):January 1, 1972Publication History Published online1 May 2002Published inissue 1 January 1972https://doi.org/10.1021/jm00271a024RIGHTS & PERMISSIONSArticle Views46Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (331 KB) Get e-Alerts Get e-Alerts
Evaluation of reference-based two-color methods for measurement of gene expression ratios using spotted cDNA microarrays (2006)

Abstract Background Spotted cDNA microarrays generally employ co-hybridization of fluorescently-labeled RNA targets to produce gene expression ratios for subsequent analysis. Direct comparison of two RNA samples in the same microarray provides the highest level of accuracy; however, due to the number of combinatorial pair-wise comparisons, the direct method is impractical for studies including large number of individual samples (e.g., tumor classification studies). For such studies, indirect comparisons using a common reference standard have been the preferred method. Here we evaluated the precision and accuracy of reconstructed ratios from three indirect methods relative to ratios obtained from direct hybridizations, herein considered as the gold-standard. Results We performed hybridizations using a fixed amount of Cy3-labeled reference oligonucleotide (RefOligo) against distinct Cy5-labeled targets from prostate, breast and kidney tumor samples. Reconstructed ratios between all tissue pairs were derived from ratios between each tissue sample and RefOligo. Reconstructed ratios were compared to (i) ratios obtained in parallel from direct pair-wise hybridizations of tissue samples, and to (ii) reconstructed ratios derived from hybridization of each tissue against a reference RNA pool (RefPool). To evaluate the effect of the external references, reconstructed ratios were also calculated directly from intensity values of single-channel (One-Color) measurements derived from tissue sample data collected in the RefOligo experiments. We show that the average coefficient of variation of ratios between intra- and inter-slide replicates derived from RefOligo, RefPool and One-Color were similar and 2 to 4-fold higher than ratios obtained in direct hybridizations. Correlation coefficients calculated for all three tissue comparisons were also similar. In addition, the performance of all indirect methods in terms of their robustness to identify genes deemed as differentially expressed based on direct hybridizations, as well as false-positive and false-negative rates, were found to be comparable. Conclusion RefOligo produces ratios as precise and accurate as ratios reconstructed from a RNA pool, thus representing a reliable alternative in reference-based hybridization experiments. In addition, One-Color measurements alone can reconstruct expression ratios without loss in precision or accuracy. We conclude that both methods are adequate options in large-scale projects where the amount of a common reference RNA pool is usually restrictive.
IL-1 is a mediator of increases in slow-wave sleep induced by CRH receptor blockade (2000)

We hypothesize that corticotropin-releasing hormone (CRH), a regulator of the hypothalamic-pituitary-adrenal (HPA) axis, is involved in sleep-wake regulation on the basis of observations that the CRH receptor antagonist astressin, after a delay of several hours, reduces waking and increases slow-wave sleep (SWS) in rats. This delay suggests a cascade of events that begins with the HPA axis and culminates with actions on sleep regulatory systems in the central nervous system. One candidate mediator in the brain for these actions is interleukin (IL)-1. IL-1 promotes sleep, and glucocorticoids inhibit IL-1 synthesis. In this study, central administration of 12.5 microgram astressin into rats before dark onset reduced corticosterone 4 h after injection and increased mRNA expression for IL-1alpha and IL-1beta but not for IL-6 or tumor necrosis factor-alpha in the brain 6 h after injection. To determine directly whether IL-1 is involved in astressin-induced alterations in sleep-wake behavior, we then pretreated rats with 20 microgram anti-IL-1beta antibodies before injecting astressin. The increase in SWS and the reduction in waking that occur after astressin are abolished when animals are pretreated with anti-IL-1beta. These data indicate that IL-1 is a mediator of astressin-induced alterations in sleep-wake behavior.
Point-source integrating-cavity absorption meter: theoretical principles and numerical modeling (1997)

A mathematical model has been developed for photon behavior within a spherical integrating-cavity absorption meter with a point light source at the center of the cavity. Explicit expressions for the average number of collisions with the wall per photon, the average path length per photon, and the transmittance of the cavity containing a water sample relative to that containing pure water are derived for an absorbing nonscattering medium. Monte Carlo modeling shows that the operation of the point-source integrating-cavity absorption meter is essentially unaffected by scattering. Calculations of the performance of the absorption meter as a function of the cavity diameter, absorption coefficient of the medium, and the reflectivity of cavity are presented.
COMPLEMENT INHIBITION WITH AN ANTI-C5 MONOCLONAL ANTIBODY PREVENTS ACUTE CARDIAC TISSUE INJURY IN AN EX VIVO MODEL OF PIG-TO-HUMAN XENOTRANSPLANTATION (1995)

Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year. The journal celebrated its 50th year in 2016. Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal.
A Novel Technique for I/Q Imbalance and CFO Compensation in OFDM Systems (2005)

In this paper, a novel baseband IQ estimation and compensation technique is proposed to overcome the joint effects of CFO (carrier frequency offset) and IQ imbalance. The proposed method uses a one-shot algorithm which is able to estimate and compensate the non-ideal effect up to a gain error of 1 dB, phase error of 10/spl deg/, and CFO of 50 ppm at a carrier frequency of 2.5 GHz in 64QAM OFDM systems. Under this condition, the system performance has less than 0.8 dB design loss in terms of PER and is shown to have more than 10 dB improvement compared with the reference design.
L’intérêt pédagogique du multimédia : bilan et perspectives (1996)

Le but de cet article est de contribuer à l’information des enseignants de langue sur les possibilités offertes par l’informatique. L’auteur justifie l’intérêt pédagogique de l’ordinateur multimédia en procédant à un bilan des avantages offerts par rapport aux objectifs recherchés. Il propose une réflexion sur le cadre de son utilisation pour l’apprentissage des langues et suggère une liste de critères de qualité que l’enseignant doit rechercher pour s’assurer de l’efficacité pédagogique de ces nouveaux outils.