gebhart/patrepeval huggingface dataset:
A novel computational biostatistics approach implies impaired dephosphorylation of growth factor receptors as associated with severity of autism (2014)

The prevalence of autism spectrum disorders (ASDs) has increased 20-fold over the past 50 years to >1% of US children. Although twin studies attest to a high degree of heritability, the genetic risk factors are still poorly understood. We analyzed data from two independent populations using u-statistics for genetically structured wide-locus data and added data from unrelated controls to explore epistasis. To account for systematic, but disease-unrelated differences in (non-randomized) genome-wide association studies (GWAS), a correlation between P-values and minor allele frequency with low granularity data and for conducting multiple tests in overlapping genetic regions, we present a novel study-specific criterion for 'genome-wide significance'. From recent results in a comorbid disease, childhood absence epilepsy, we had hypothesized that axonal guidance and calcium signaling are involved in autism as well. Enrichment of the results in both studies with related genes confirms this hypothesis. Additional ASD-specific variations identified in this study suggest protracted growth factor signaling as causing more severe forms of ASD. Another cluster of related genes suggests chloride and potassium ion channels as additional ASD-specific drug targets. The involvement of growth factors suggests the time of accelerated neuronal growth and pruning at 9-24 months of age as the period during which treatment with ion channel modulators would be most effective in preventing progression to more severe forms of autism. By extension, the same computational biostatistics approach could yield profound insights into the etiology of many common diseases from the genetic data collected over the last decade.
Ascorbate and dehydroascorbate measurements in aqueous solutions and plasma determined by gas chromatography-mass spectrometry (1993)

The tert-butyldlmethylsllyl derivatives of ascorbic acid and dehydroascorbic acid were characterized by gas chromatography-mass spectrometry, and an isotope dilution assay for ascorbate and dehydroascorbate was developed using [13C6]ascorbic acid and [13C6]- and [6,6-2H2]dehydroascorbate. This assay was used to monitor ascorbic acid loss and the resulting rise of dehydroascorbic acid in aqueous solutions and plasma. Ascorbic acid was shown to rapidly decompose in aqueous solutions containing transition metal ions or when exposed to oxygen. Ethylenedlaminetetraacetic acid chelation did not prevent ascorbic acid degradation in aqueous solution, and ascorbate in ethylenedlaminetetraacetic acid chelated plasma was converted to dehydroascorbate on freezing. Gas chromatography-mass spectrometry appears to be a satisfactory method for determining the ascorbate and dehydroascorbate content of solutions including human blood plasma, whether or not there is ongoing oxidation of ascorbate in those solutions.
Particle nucleation in emulsion polymerization. II. Nucleation in emulsifier‐free systems investigated by seed polymerization (1979)

Abstract Experiments with seeded polymerization in emulsifier‐free systems were carried out with styrene in order to test the theory of particle nucleation presented in the first article in this series. The effect of amount, size, and surface charge density of the seed particles on the formation of new particles was investigated. An expression for the capture rate of oligomeric radicals from the water phase was evaluated in which the rate of capture was considered to be governed by the absorption of oligomers with chain length one less than the critical chain length for precipitation of the oligomer. Coagulation of primary particles was also included in the expression for the number of new particles obtained in the system. Limited coagulation of primary particles with already formed particles and with seed particles was found to play an important role in determining the final number of new particles found at the end of the runs.
The Use of an Antibiotic-Impregnated, Osteoconductive, Bioabsorbable Bone Substitute in the Treatment of Infected Long Bone Defects: Early Results of a Prospective Trial (2002)

In patients with posttraumatic osteomyelitis, the bone graft substitute was effective in eradicating bone infection in 23 of 25 patients. Isolated bony defects healed reliably (nine of nine) following addition of bone graft substitute alone. The role of the bone graft substitute in isolation in the treatment of nonunion is unclear at present.
Imporving RPR fairness convergence (2005)

IEEE 802.17 RPR is a MAN candidate due to its ability to achieve fairness and fast restoration. However, the proposed fairness scheme may lead to slow convergence and permanent oscillation. This letter proposes a novel fast-convergent scheme to provide fairness using estimated number of unbounded flows in each link. After detailed evaluations and simulations, the proposed scheme is proven to allocate bandwidth fairly among flows fast-convergently and achieve high utilization at the same time.
Design and Evaluation of iMesh: An Infrastructure-Mode Wireless Mesh Network (2005)

We have designed and evaluated iMesh, an infrastructure-mode 802.11-based mesh network. IEEE 802.11 access points double as routers making the network architecture completely transparent to mobile clients, who view the network as a conventional wireless LAN. Layer-2 handoffs between access points trigger routing activities inside the network, which can be thought of as layer-3 handoffs. We describe the design rationale and a testbed implementation of iMesh. We present results related to the handoff performance. The results demonstrate excellent handoff performance, the overall latency varying between 50-100 ms, depending on different layer-2 techniques, even when a five-hop long route update is needed. Various performance measurements also demonstrate the clear superiority of a flat routing scheme relative to a more traditional, Mobile IP-like scheme to handle layer-3 handoff.
Documents (2019)

Founded by the art dealer Georges Wildenstein and endorsed by the ethnologists from the Institut de l’Ethnologie, Documents is a nonconformist magazine of art, archaeology, ethnography, and diverse aspects of contemporary popular culture. Between 1929 and 1930, it published fifteen issues whose cont
Design of RoF based mobile fronthaul link with multi-IF carrier for LTE/LTE-A signal transmission (2014)

We report a design of RoF based mobile fronthaul link considering quality of optical link and LTE/LTE-A signal simultaneously. The requirement of CNR in analog link supporting LTE/LTE-A services is presented, and effects of analog link quality on LTE/LTE-A signal is investigated. The EVM measurement after transmission of LTE-A signal with various numbers of intermediate frequency over 20 km SMF link is also presented.
Benefits of Compressor Inlet Air Cooling for Gas Turbine Cogeneration Plants (1995)

Compressor inlet air cooling is an effective method for enhancing the performance of gas turbine plants. This paper presents a comparative analysis of different solutions for cooling the compressor inlet air for the LM6000 gas turbine in a cogeneration plant operated in base load. Absorption and evaporative cooling systems are considered and their performance and economic benefits compared for the dry low-NOx LM6000 version. Reference is made to two sites in Northern and Southern Italy, whose climatic data series for modeling the variations in ambient temperature during the single day were used, to account for the effects of climate in the simulation. The results confirmed the advantages of inlet air cooling systems. In particular, evaporative cooling proved to be cost-effective, though capable of supplying only moderate cooling, while absorption systems have a higher cost but are also more versatile and powerful in base load operation. An integration of the two systems proved to be able to give both maximum performance enhancement and net economic benefit.
Characterization of transposon insertion out- mutants of Erwinia carotovora subsp. carotovora defective in enzyme export and of a DNA segment that complements out mutations in E. carotovora subsp. carotovora, E. carotovora subsp. atroseptica, and Erwinia chrysanthemi (1990)

Soft-rotting Erwinia spp. export degradative enzymes to the cell exterior (Out+), a process contributing to their ability to macerate plant tissues. Transposon (Tn5, Tn10, Tn10-lacZ) insertion Out- mutants were obtained in Erwinia carotovora subsp. carotovora 71 by using plasmid and bacteriophage lambda delivery systems. In these mutants, pectate lyases, polygalacturonase, and cellulase, which are normally excreted into the growth medium, accumulated in the periplasm. However, localization of the extracellular protease was not affected. The Out- mutants were impaired in their ability to macerate potato tuber tissue. Out+ clones were identified in a cosmid library of E. carotovora subsp. carotovora 71 by their ability to complement mutants. Localization of cyclic phosphodiesterase in the periplasm indicated that the Out+ plasmids did not cause lysis or a nonspecific protein release. The Out+ derivatives of the E. carotovora subsp. carotovora 71 mutants regained the ability to macerate potato tuber tissue. Our data indicate that a cluster of several genes is required for the Out+ phenotype. While one plasmid, pAKC260, restored the Out+ phenotype in each of the 31 mutants of E. carotovora subsp. carotovora, E. carotovora subsp. atroseptica, and Erwinia chrysanthemi, it failed to render Escherichia coli export proficient. Homologs of E. carotovora subsp. carotovora 71 out DNA were detected by Southern hybridizations in subspecies of E. carotovora under high-stringency conditions. In contrast, E. chrysanthemi sequences bearing homology to the E. carotovora subsp. carotovora 71 out DNA were detectable only under low-stringency hybridization. Thus, although the out genes are functional in these two soft-rotting bacterial groups, the genes appear to have diverged.
Product and service testing methodology and ISO 9000 (2002)

During a product and/or service development life cycle, testing is one of critical processes to ensure the quality of the product or service before delivering to a customer. Ideally quality assurance is enforced from the beginning of the development life cycle, so that problems can be discovered early and cost of rework can be reduced. However, the industry has not been able to eliminate the need for extensive testing. With continuing customer demands for shorter cycle time and better quality, testing takes on a new meaning and requires innovative methodologies to assure quality results. Due to the growth in global business, ISO 9000 becomes a much more important set of quality standards for dealing with product or service quality issues among global suppliers and customers. This paper first presents an overview of a product and service development process and focuses on the testing methodologies and their relationship to ISO 9000.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Methodnon-uniformity in short-read rates in RNA-Seq data (2010)

After mapping, RNA-Seq data can be summarized by a sequence of read counts commonly modeled as Poisson variables with constant rates along each transcript, which actually fit data poorly. We suggest using variable rates for different positions, and propose two models to predict these rates based on local sequences. These models explain more than 50% of the variations and can lead to improved estimates of gene and isoform expressions for both Illumina and Applied Biosystems data.
Design and modelling of permanent magnet micro-bearings (1998)

A model of micro-dimensioned permanent magnet bearings for micromotors is proposed. 2D and 3D modelling and simulation of scaled-down classical structures were carried out using 3 complementary computation methods. Their application to thick-film magnets technology is considered.
Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice (1982)

A double mutant of Cryptococcus neoformans which lacked the ability to produce melanin (Mel-) on media containing diphenols and failed to grow at 37 degrees C (temperature sensitive, Tem-) was obtained by UV irradiation and subsequent cloning. The mutant showed two lesions in melanogenesis in that it lacked the active transport system for diphenolic compounds and also lacked phenoloxidase. Ultrastructures of the mutant and wild-type cells grown on a medium with or without L-dopa showed that only the wild-type cells grown on L-dopa medium formed a dark cell wall layer, presumably containing melanin. The mutant was crossed with a wild type, and the phenotypes of the progeny were analyzed. The analysis showed no linkage between the mating type and either Mel or Tem loci, but loose linkage was seen between Mel and Tem loci. The progeny, Mel+ Tem+, Mel+ Tem-, Mel- Tem+, and Mel- Tem-, were studied for their virulence in mice. Only Mel+ Tem+ types killed mice with an inoculum of 5 X 10(5) cells within 50 days.
56 Human lysophosphatidic acid acyltransferase is encoded by a gene located in the Major Histocompatibility Complex (1997)

Conference Article| November 01 1997 56 Human lysophosphatidic acid acyltransferase is encoded by a gene located in the Major Histocompatibility Complex BEGOÑA AGUADO; BEGOÑA AGUADO 1MRC Immunochemistry Unit, Department of Biochemistry, Oxford University, South Parks Road, Oxford OX1 3QU, UK Search for other works by this author on: This Site PubMed Google Scholar R. DUNCAN CAMPBELL R. DUNCAN CAMPBELL 1MRC Immunochemistry Unit, Department of Biochemistry, Oxford University, South Parks Road, Oxford OX1 3QU, UK Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1997) 25 (4): S597. https://doi.org/10.1042/bst025s597 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation BEGOÑA AGUADO, R. DUNCAN CAMPBELL; 56 Human lysophosphatidic acid acyltransferase is encoded by a gene located in the Major Histocompatibility Complex. Biochem Soc Trans 1 November 1997; 25 (4): S597. doi: https://doi.org/10.1042/bst025s597 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1997 Biochemical Society1997 Article PDF first page preview Close Modal You do not currently have access to this content.
Age‐related changes in the glutathione redox system (2001)

The effect of aging on the glutathione redox system was evaluated in this study. For this purpose, we determined reduced glutathione (GSH) and oxidized glutathione (GSSG) in whole blood, glutathione peroxidase (GPx) and glutathione reductase (GSSGR) in erythrocytes and selenium (Se) in plasma in 176 healthy individuals. We also calculated GSH/GSSG molar ratios. These subjects were divided into five groups: group 1 (n=25; 0.2-1 years old); group 2 (n=28; 2-11 years old); group 3 (n=23; 12-24 years old); group 4 (n=40; 25-40 years old); group 5 (n=60; 41-69 years old). GSH levels in groups 1 and 5 were significantly lower than the other groups (p<0.001). Conversely, GSSG levels were significantly high in these periods (p<0.001). The GSH/GSSG molar ratio was found to be low both in the first year of life and in the oldest group (p<0.001, respectively). GPx activity in group 5 was increased as compared to the other groups (p<0.001). GSSGR activity was significantly lower in the oldest groups than in the other groups (p<0.001). Se levels were found to be low in the oldest group (p<0.001). Selenium levels of women in group 5 were significantly high as compared to the men (p<0.01). We found negative correlations between age and GSH levels (r=0.402; p<0.001), selenium levels (r=0.454; p<0.001), GSH/GSSG molar ratio (r=0.557; p<0.001) and GSSGR activity (r=0.556; p<0.001). There were positive correlations between age and GPx (r=0.538; p<0.001) and GSSG level (r=0.551; p<0.001). In conclusion, our findings show that the glutathione redox system is affected by age. Oxidative stress increases during the aging process. There is no effect of aging on the glutathione redox system according to sex except for the Se level.
Evaluation and management of angioimmunoblastic T-cell lymphoma: a review of current approaches and future strategies. (2008)

Angioimmunoblastic T-cell lymphoma (AITL) is a rare and complex lymphoproliferative disorder, clinically characterized by widespread lymphadenopathy, extranodal disease, immune-mediated hemolysis, and polyclonal hypergammaglobulinemia. Significant progress has been made in the understanding of AITL since its recognition as a clonal T-cell disorder with associated deregulation of B-cells and endothelial cells within a unique malignant microenvironment. However, as the responses to conventional chemotherapy have not been durable, prognosis with current treatment approaches has remained dismal. Here we review the clinical presentation, prognosis, and management of patients with AITL. We discuss recent developments in the understanding of the pathogenesis of AITL at a cellular and molecular level, including the implication of the follicular helper T-cell as the corresponding cell of origin, the roles of Epstein-Barr virus, B-cell deregulation, angiogenesis, and other signaling pathways in AITL, and the therapeutic implications of these findings. Finally, we discuss recent clinical trials and novel treatment approaches in the management of patients with AITL.
Efficiency in fruit marketing: Accuracy and cost of small-sample grading systems for California fruit packing houses (1953)

This article is the second section of Part VIII of a series of reports on the effects of packing-house equipment, plant layout, and work methods on efficiency and costs. These studies have been made co-operatively by the University of California Giunnini Foundation of Agricultural Economics and the United States Department of Agriculture under the authority of the Research and Marketing Act of 1946
Synthesis of Vertex-Differentiated Icosahedral <i>closo</i>-Boranes: Polyfunctional Scaffolds for Targeted Drug Delivery (2012)

We report methods for the synthesis of vertex-differentiated icosahedral closo-boranes. A single B-OH vertex of the icosahedral borane [closo-B(12)(OH)(12)](2-) was derivatized to prepare [closo-B(12)(OR)(OH)(11)](2-) using optimized alkylation conditions and purification procedures. Several representative vertex-differentiated icosahedral closo-boranes were prepared utilizing carbonate ester and azide-alkyne click chemistries on the surface of the closo-B(12)(2-) core.
Tailoring particle arrays by isotropic plasma etching: an approach towards percolated perpendicular media (2009)

Plasma etching of densely packed arrays of polystyrene particles leads to arrays of spherical nanostructures with adjustable diameters while keeping the periodicity fixed. A linear dependence between diameter of the particles and etching time was observed for particles down to sizes of sub-50 nm. Subsequent deposition of Co/Pt multilayers with perpendicular magnetic anisotropy onto these patterns leads to an exchange-decoupled, single-domain magnetic nanostructure array surrounded by a continuous magnetic film. The magnetic reversal characteristic of the film-particle system is dominated by domain nucleation and domain wall pinning at the particle locations, creating a percolated perpendicular media system.
Biological Control of<i>Meloidogyne javanica</i>with<i>Bacillus penetrans</i> (1984)

Mode d'action de l'agent sur plants de tomate et etude de son efficacite. Presence naturelle sur la vigne. Etude en pots et au champ
Games for engaged learning of middle school children with special learning needs (2012)

Abstract In this paper, we describe an in situ study that examined the diverse design features and effects of three pre‐algebra games for middle school children who have either challenges with learning or different language backgrounds. Data were collected through in‐field observation, artifact analysis, school performance report and knowledge test during 15 one‐hour gaming sessions over a period of 3 weeks. A list of key design features related to creating engagement and learning for students with special learning needs emerged from the data. The findings and discussions will inform educational designers and practitioners on successful educational game design and implementation for learners with diverse characteristics and needs. Practitioner notes What is already known about this topic Computer games can act as rich primers for engaged learning of academic content. What this paper adds The potential for computer games to promote engaged learning for school children with learning difficulty or different language/cultural backgrounds. The common and unique game design features that promote engaged learning for school children with special learning needs. Game‐based learner support for school children with special learning needs. Implications for practice and/or policy Educational game designers should make purposeful design efforts (eg, a simple fantasy, open‐ended game challenges and scaffolding with visual cue/feedback) to create learner‐adaptive engagement. Content processing should be a core and active part of the game‐play to promote game‐based learning. Adaptive and nonintrusive support should be provided to student players to reinforce game‐based learning.
Molecular cloning of TOL genes xylB and xylE in Escherichia coli (1981)

The xylB and xylE genes in the TOL plasmid of Pseudomonas putida mt-2, which code for benzyl alcohol dehydrogenase and catechol 2,3-oxygenase, respectively, were cloned onto plasmid pBR322 in Escherichia coli for detailed mapping. The xylB gene was mapped in a 2.9-kilobase region within the BamHI BC fragment of pTN2, an in vivo RP4-TOL recombinant, whereas the xylE gene was mapped in a 1.8-kilobase region within the BamHI BD fragment. The directions of transcription of these genes were deduced from the expression of the cloned genes which had been ligated in orientations opposite pBR322 at its BamHI site within the tetracycline resistance gene. The xylB and xylE genes are inducible by a specific inducer of the TOL pathway genes in the RP4-TOL recombinant, whereas they are not inducible in the pBR322-TOL hybrids. The regulatory regions involved in expression of the xylB and xylE genes do not appear to be located in the vicinity of the structural genes. Catechol 2,3-oxygenase formed in E. coli carrying an xylE-containing plasmid is similar, or identical, to that formed in P. putida carrying the TOL plasmid.