gebhart/patrepeval huggingface dataset:
The Oenococcus oeni genome: physical and genetic mapping of strain GM and comparison with the genome of a ‘divergent’ strain, PSU-1 (2000)

The physical and genetic maps of the Oenococcus oeni strains GM and PSU-1, which represent two genomic divergent groups on the basis of macrorestriction and ribotyping analysis, were compared. To achieve this comparison, the GM maps were constructed and the PSU-1 maps, already established, were improved. All the recognition sites of the restriction enzymes ASC:I, I-CEU:I, FSE:I, NOT:I and SFI:I were located in both chromosomes and the position of 26 genetic markers, including two rrn operons and 14 new putative oenococcal genes, were allocated to the restriction fragments generated by the five enzymes. The comparative analysis of O. oeni GM and PSU-1 genomes revealed extensive conservation of loci order. As for the differences encountered in the locations of restriction sites, they seem to be a reflection of the differences in restriction fragment sizes, explainable by insertion/deletion events and point mutations. No evidence for major genomic rearrangements was found. The genomic conservation between the two strains is in agreement and suggests homogeneity within the species, which was not unexpected in view of the restricted ecological niche of O. oeni. Further comparisons of physical maps, both of O. oeni strains and related species, will certainly help to assess whether O. oeni is really an homogeneous species and physical mapping is suitable for taxonomic purposes, both at the supra- and intraspecific levels.
The Isolation of a Neutral Proteinase from the Urine of a Patient with Goodpasture's Syndrome (1978)

Conference Article| October 01 1978 The Isolation of a Neutral Proteinase from the Urine of a Patient with Goodpasture's Syndrome MALCOLM DAVIES; MALCOLM DAVIES 1Kidney Research Unit Foundation for Wales, Welsh National School of Medicine, Royal Infirmary, Cardiff CF2 1SZ, Wales, U.K. Search for other works by this author on: This Site PubMed Google Scholar ERIC SANDERS; ERIC SANDERS 2Kidney Research Unit Foundation for Wales, Welsh National School of Medicine, Royal Infirmary, Cardiff CF2 1SZ, Wales, U.K. Search for other works by this author on: This Site PubMed Google Scholar GERALD A. COLES; GERALD A. COLES 3Kidney Research Unit Foundation for Wales, Welsh National School of Medicine, Royal Infirmary, Cardiff CF2 1SZ, Wales, U.K. Search for other works by this author on: This Site PubMed Google Scholar KELVIN T. HUGHES KELVIN T. HUGHES 4Kidney Research Unit Foundation for Wales, Welsh National School of Medicine, Royal Infirmary, Cardiff CF2 1SZ, Wales, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1978) 6 (5): 947–949. https://doi.org/10.1042/bst0060947 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation MALCOLM DAVIES, ERIC SANDERS, GERALD A. COLES, KELVIN T. HUGHES; The Isolation of a Neutral Proteinase from the Urine of a Patient with Goodpasture's Syndrome. Biochem Soc Trans 1 October 1978; 6 (5): 947–949. doi: https://doi.org/10.1042/bst0060947 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1978 Biochemical Society1978 Article PDF first page preview Close Modal You do not currently have access to this content.
<i>In vitro</i> efficacy of <scp>l</scp>‐asparaginase in childhood acute myeloid leukaemia (2003)

To explore the potential efficacy of l-asparaginase treatment in acute myeloid leukaemia (AML) patients, we studied the in vitro resistance of French-American-British (FAB) subtypes of childhood AML to l-asparaginase using a methyl-thiazol-tetrazolium assay. We tested leukaemic cells obtained from 177 common acute lymphoblastic leukaemia (cALL) and 228 AML children at diagnosis. The median 70% lethal dose of l-asparaginase (LD70asp) (U/ml) was 0.46 in the cALL and 6.70 in the AML samples. The median LD70asp among each FAB subtype of AML was 0.76 (M0), 0.46 (M1), 10.00 (M2), 10.00 (M3), 1.18 (M4), 1.35 (M5) and 10.00 (M7). Type M3 samples had the highest LD70asp. The LD70asp of the M2 samples was significantly higher than that of the M1, M4 and M5 samples. When the LD70asp values were classified as low (0.016-0.159), intermediate (0.16-1.59) or high (1.6-10.00), the frequency of low, intermediate or high LD70asp among the M1 samples were similar to those among the cALL samples. In conclusion, cells from AML types M1, M4 and M5 were relatively sensitive to l-asparaginase, and M1 cells were as sensitive as those of cALL, suggesting that l-asparaginase treatment may be effective for these subtypes of AML.
The doctoral writing conversation: establishing a generic doctoral writing programme (2017)

Over the past few decades, the number of people enrolled in doctoral study has increased dramatically across the world. In practical terms, this has meant that universities now receive increasingly diverse students with regard to ethnicity, age, language, culture, and background preparedness for higher degree study. Students can, and often do, begin their doctorates with scant understanding of the precise expectations and rigorous demands of thesis writing. Yet, regardless of academic discipline, successful completion of a doctorate requires a written thesis. To help students master thesis writing requirements, a proliferation of self-help writing books, blogs, specific writing techniques, and programmes have emerged. This paper describes an approach developed at a New Zealand university where a generic doctoral writing programme, the Doctoral Writing Conversation, has evolved to make explicit to students the implicit language understanding that accomplished academic writers use to produce text. Utilising the idea of language as a tool to mediate understanding, the paper will explore how the programme is structured and functions but will also describe some of the insights I have gained along the way.
Early experiences with the stable isotope method in children. (1990)

A new technique to estimate water uptake by the gastrointestinal tract was tested in infants undergoing elective surgery. Patients were randomly allocated to receive either sterile water or a glucose-electrolyte solution labeled with the stable isotope H2O18. After absorption, the isotopic O18 comes to rapid equilibrium with plasma bicarbonate and subsequently appears in the breath as C18O2. Breath and blood samples were collected at five-minute intervals after administration of the test solution. Mass spectrometric analysis enabled detection of isotopic O18 enrichment at parts per million levels in blood and in breath CO2. Enrichment of blood and breath C18O2 above baseline levels is detectable within five minutes of administration of the labeled test solution and rises to a plateau between 30 and 90 minutes. It is hypothesized that the rate of increase of enrichment is proportional to the unidirectional flux of water from lumen to gut.
A Chromatographic Impurity Signature Profile Analysis for Cocaine Using Capillary Gas Chromatography (1991)

Abstract The signature patterns of cocaine samples were examined by capillary gas chromatography using 14 impurities commonly found in illicit cocaine samples. The procedure is based on acidic, basic, and neutral impurities introduced from the coca plant and from the processing of cocaine in clandestine laboratories. Impurities containing either alcoholic, N-nor, or carboxylic acid functional groups were analyzed as their silyl derivatives. The reported procedure provides a simple one-step assay for obtaining chromatographic impurity signature profile analyses (CISPA) of illicit cocaine samples using flame ionization detection (FID).
Advent of Greige Cotton Non-Wovens Made using a Hydro-Entanglement Process (2010)

Using greige (scour/bleach-less) cotton, non-woven fabrics have been successfully produced by adopting conventional fiber opening, cleaning and (modified) carding machines followed by cross-lapping, pre/light needling, and hydro-entanglement (HE) on modern commercial machinery and equipment. Using standard test methods and procedures, the fabrics were evaluated for their weight, thickness, burst strength, tensile and tear failures in both machine (MD) and cross (CD) directions, and absorbency. Dimensional characteristics of the fabrics were determined before and after an ordinary wash. Microscopic examinations of the fiber/fabric surfaces before and after various conditions/degrees of H-E were conducted. Results of these preliminary research investigations have shown that a run-of-the-mill greige cotton, processed on a conventional cotton cleaning and preparatory system, can indeed be efficiently processed on the downstream non-wovens production equipment. In addition, it has been shown that different processing conditions, especially the high-pressure (HP) hydraulic energy of the H-E system, have a considerable influence on properties of the fabrics produced. At the nominal fabric production rates deployed in the research trials, pressure greater than 100 bar (at the system’s two HP jet-heads) produces a fabric that is partially hydrophilic: a desirable attribute for many end-use applications of cotton non-wovens. Based on a previous in-house investigation, it seems that the HP (hydraulic energy) at certain levels partly removes some of the greige cotton fiber’s natural hydrophobic defensive membrane (outer-surface barrier) of heavy hydrocarbons, such as waxes, pectins, etc., thus making the fiber/fabric partially hydrophilic. Further, it has been observed that the high water pressures (HP), under otherwise similar processing conditions, tend to fracture some cotton fibers into tiny fibrils, as evidenced by scanning electron microscopy (SEM) images. These ruptured fibers, by way of exposing their inner (hydrophilic) walls, could also partly contribute to the fabric’s improved absorbency at elevated hydraulic energy levels. Furthermore, a rather unique fabric structure, comprising certain well-defined fibrous “strands and channels,” observed at elevated (HP) pressures is also deemed to partly contribute to the greige fabric’s improved wickability.
Synthesis of Amine-Terminated Aliphatic Polycarbonates via Al(Et)<sub>2</sub>(OR)-Initiated Polymerizations (1997)

New aliphatic polycarbonates derived from trimethylene carbonate (1) (TMC, 1,3-dioxan-2-one),have been prepared by ring opening polymerization. The synthesis is achieved by using new aluminum alkoxide initiators which allow for the incorporation of controlled functionality in the resulting polymer. The synthesis of poly(TMC) with nitrophenyl end groups was achieved by using initiators of the form, Al(Et)3-x(OR)x; where x = 1−2, R = −(CH2)2PhNO2. The end groups could be reduced to give the corresponding aminophenyl end-capped poly(TMC). In these polymerizations, molecular weight is proportional to the monomer/intiator ratio, with each polymer chain containing one nitrophenyl or aminophenyl functionality.
Relation between the Boson Expansion Theory and the Boson-Fermion Expansion Theory (1994)

The relation between the hermitian type boson expansion theory and the boson-fermion expansion theory recently proposed as the alternative to it is discussed. It is shown that the apparent difference between some of the expansion coefficients in both theories is due to arbitrariness about the definition of the collective state in the fermion space and that one can remove the difference by the appropriate unitary transformation.
Linguistic Codes, Hesitation Phenomena and Intelligence (1962)

Two linguistic codes have been proposed, elaborated and restricted. These codes are regarded as functions of different social structures. The codes are considered to entail qualitatively different verbal planning orientations which control different modes of self-regulation and levels of cognitive behaviour. Social class differences in the use of the codes were postulated and the hesitation phenomena associated with them predicted. Speech samples were obtained and the hesitation phenomena analysed from a discussion situation involving small groups of middle-class and working-class subjects with varying I.Q. profiles.
Omphalotin, A New Cyclic Peptide with Potent Nematicidal Activity from<i>Omphalotus Olearius</i>I. Fermentation and Biological Activity (1997)

Abstract Omphalotin (1), a new cyclic peptide possessing strong and selective nematicidal activity against the plant pathogenic Meloidogyne incognita, was isolated from cultures of the basidiomycete Omphalotus olearius together with the antibiotic sesquiterpene illudin M (2) and the inactive 3-(3-indolyl)-N−methylpropanamide (3). Omphalotin (1) is only weakly active against the saprophytic nematode Caenorhabditis elegans, it is weakly cytotoxic at 100 μg/ml but shows no phytotoxic, antibacterial or antifungal activities. The fermentation of O, olearius and the production of the metabolites as well as the evaluation of their biological activities are reported.
Exact Camera Location Recovery by Least Unsquared Deviations (2018)

We establish exact recovery for the Least Unsquared Deviations (LUD) algorithm of Özyeşil and Singer. More precisely, we show that for sufficiently many cameras with given corrupted pairwise directions, where both camera locations and pairwise directions are generated by a special probabilistic model, the LUD algorithm exactly recovers the camera locations with high probability. A similar exact recovery guarantee for camera locations was established for the ShapeFit algorithm by Hand, Lee, and Voroninski, but with typically less corruption.
Photothermal microscope for high-<i>T</i> <i>c</i> superconductors and charge density waves (1993)

We have developed a new photothermal technique to investigate electronic phase transitions associated with high temperature superconductivity and charge density waves (CDW). The phase shift of the thermal wave yields the anisotropic thermal diffusivity coefficient of the sample. The amplitude of the photothermal signal is sensitive to electronic phase transitions of the second kind and measures directly the effect of thermodynamic fluctuations near the transitions. This noncontacting high-definition technique is well suited to measurements of small and fragile samples. Good comparisons between our experimental results and second-order phase transition theory are obtained on a high-Tc superconductor and a CDW sample.
Leveraging Video Descriptions to Learn Video Question Answering (2017)

We propose a scalable approach to learn video-based question answering (QA): to answer a free-form natural language question about the contents of a video. Our approach automatically harvests a large number of videos and descriptions freely available online. Then, a large number of candidate QA pairs are automatically generated from descriptions rather than manually annotated. Next, we use these candidate QA pairs to train a number of video-based QA methods extended from MN (Sukhbaatar et al. 2015), VQA (Antol et al. 2015), SA (Yao et al. 2015), and SS (Venugopalan et al. 2015). In order to handle non-perfect candidate QA pairs, we propose a self-paced learning procedure to iteratively identify them and mitigate their effects in training. Finally, we evaluate performance on manually generated video-based QA pairs. The results show that our self-paced learning procedure is effective, and the extended SS model outperforms various baselines.
The Use of Vibrational Optical Coherence Tomography in Matching Host Tissue and Implant Mechanical Properties (2018)

Synthetic implants, allografts, and xenografts are used for repair and replacement of tissues in numerous surgical applications each year. A number of the grafts used as hernia replacements or for repair of other tissues require revision surgery due to modulus mismatches that occur at the implant-tissue interface. A variety oftests have been used to elucidate mechanical properties of tissues and implants that are not applicable to in vivo evaluations.We have reported the use of vibrational optical coherence tomography (OCT) to image and measure the mechanical properties of both natural and synthetic polymers. In this paper, we discuss use of this technique to match moduli of host tissues and implants. While skin and other soft tissues have moduli of between 0.5 and 5.2 MPa under physiologic conditions, polymers have moduli between 56.5 MPa and 2000 MPa and metals have moduli up to 250,000 MPa. Use of vibrational OCT to image and determine the moduli of both host tissues and implants will lead to limiting modulus mismatches that contribute to implant failure. In addition, use of this technique will minimize the need to sacrifice animals in pre-clinical studies and reduce the number of biopsies needed to do differential diagnosis in the clinic.
Multicriteria Design of Hybrid Power Generation Systems Based on a Modified Particle Swarm Optimization Algorithm (2009)

Multisource hybrid power generation systems are a type of representative application of the renewables' technology. In this investigation, wind turbine generators, photovoltaic panels, and storage batteries are used to build hybrid generation systems that are optimal in terms of multiple criteria including cost, reliability, and emissions. Multicriteria design facilitates the decision maker to make more rational evaluations. In this study, an improved particle swarm optimization algorithm is developed to derive these nondominated solutions. Hybrid generation systems under different design scenarios are designed based on the proposed approach. First, a grid-linked hybrid system is designed without incoroprating system uncertainties. Then, adequacy evaluation is conducted based on probabilistic methods by accounting for equipment failures, time-dependent sources of energy, and stochastic generation/load variations. In particular, due to the unpredictability of wind speed and solar insolation as well as the random load variation, time-series models are adopted to reflect their stochastic characteristics. An adequacy evaluation procedure including time-dependent sources, is adopted. Sensitivity studies are also carried out to examine the impacts of different system parameters on the overall design performance.
An efficient thread architecture for a distributed shared memory on symmetric multiprocessor clusters (2002)

The purpose of the paper is to demonstrate an efficient thread architecture for a distributed shared memory (DSM) system on symmetric multiprocessor (SMP) clusters. For DSM systems on SMP, how to utilize the processors efficiently without wasting available computational power is a major issue. We discuss three approaches that use the process, the kernel level thread, and the user level thread to map application threads onto execution entities respectively. Considering the advantages and disadvantages of each method, we construct our thread package by combining both the user level thread and the kernel level thread. User level threads correspond to application threads and kernel level threads schedule these user level threads across multiple processors. Threads are light weighted and can be migrated in our thread package. With this thread architecture, our DSM system performs well in elementary experiments.
Postoperative pelvic hypofractionated accelerated radiotherapy with cytoprotection (HypoARC) for high-risk or recurrent prostate cancer. (2012)

Postoperative HypoARC is feasible with low-grade early and late toxicities, and emerges as a candidate for evaluation in randomized trials. The three-fold reduction of the overall treatment time renders HypoARC appealing for busy radiotherapy departments.
Fetal electrocardiography: feasibility of long‐term fetal heart rate recordings (2008)

The feasibility and accuracy of long-term transabdominal fetal electrocardiogram (fECG) recordings throughout pregnancy were studied using a portable fECG monitor. Fifteen-hour recordings of fetal heart rate (FHR) were performed in 150 pregnant women at 20-40 weeks of gestation and 1-hour recordings were performed in 22 women in labour and compared with simultaneous scalp electrode recordings. When >or=60% of fECG signals was present, the recording was defined as good. Eighty-two percent (123/150) of antenatal recordings were of good quality. This percentage increased to 90.7 (136/150 recordings) when only the night part (11 p.m.-7 a.m.) was considered. Transabdominal measurement of FHR and its variability correlated well with scalp electrode recordings (r=0.99, P<0.01; r=0.79, P<0.01, respectively). We demonstrated the feasibility and accuracy of long-term transabdominal fECG monitoring.
Synthesis of 6-Substituted Nicotinic Acid Derivatives as Analogs of Ergot Alkaloids<sup>1a,b</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 6-Substituted Nicotinic Acid Derivatives as Analogs of Ergot Alkaloids1a,bJacob Lehrfeld, Allan M. Burkman, and James E. GearienCite this: J. Med. Chem. 1964, 7, 2, 150–154Publication Date (Print):March 1, 1964Publication History Published online1 May 2002Published inissue 1 March 1964https://pubs.acs.org/doi/10.1021/jm00332a007https://doi.org/10.1021/jm00332a007research-articleACS PublicationsRequest reuse permissionsArticle Views112Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Not as Easy as It Looks: Regulating Effective Corporate Governance (2003)

Accounting scandals, executive misconduct, and poor management at once-prosperous corporations have shaken investor confidence in corporate integrity, and worse, in the mechanisms that are supposed to ensure good corporate management. What will it take to restore confidence? This Commentary suggests that the markets will respond with innovations and adjustments that lead to better management, accounting, and disclosure. Greater government policing has an important, but limited, role to play.
Isolation Effect between DC supply Voltage Signal Lines in Wireless LAN Module (2009)

A compact RF front-end module (FEM) for Wireless LAN (WLAN) application was proposed by merging DC supply voltage lines. The proposed module had one DC supply voltage line and one external shunt capacitor. This paper approached the aspect of isolation among DC supply voltage signal lines instead of using RF chokes or external shunt capacitors. Three types of module were designed and fabricated to verify the effect corresponding to isolation. A tested FEM consists of a SiGe Power Amplifier (PA), DPDT switch, a BPF for Rx, a LPF for Tx, a matching circuit for PA, and a structure for merging DC supply voltage signal lines. The performance of PA was improved along with large isolation. Measured results of the module using a proposed approach showed a P1dB 24 dBm with a 3.3 V supply. The measured adjacent-channel power ratios (ACPR) at first side-lobe and second side-lobe are -32.4 dBc and -57.9 dBc at an 18 dBm output power, respectively.