gebhart/patrepeval huggingface dataset:
The Clinicopathological and Prognostic Significance of IDO1 Expression in Human Solid Tumors: Evidence from a Systematic Review and Meta-Analysis (2018)

High expression of IDO1 is associated with poor clinical outcomes. IDO1 could serve as a biomarker of prognosis and a potential predictive factor of clinicopathology in various cancers. Further studies should be performed to verify the clinical utility of IDO1 in human solid tumors.
Anti-Ia Reactivity in Sera from Patients with Systemic Lupus Erythematosus (1982)

Antileukocyte antibodies in sera from patients with systemic lupus erythematosus (SLE) were characterized by determining cross-reacting specificies with the antigens defined by OKT3, OKT4, OKT8, OKM1 and anti-Ia hybridoma antibodies (Abs). T cells were prepared by sheep erythrocyte (E) rosetting after removal of adherent cells. T cells, or non-T cells, were preincubated with SLE sera at 4 degrees C and then with monoclonal Abs. Binding by specific monoclonal Abs was assessed by two methods: rosetting with ox erythrocytes conjugated with goat anti-mouse IgG and also in the fluorescence-activated cell sorter using fluorescein isothiocyanate-conjugated goat anti-mouse IgG. Using the rosetting method, we found that sera from SLE can block the binding of monoclonal mouse hybridoma anti-Ia Abs to T cells; the blocking of other monoclonal Abs was not consistent. Using fluorescence-activated cell sorter analysis, preincubation with SLE sera lowered the intensity of staining and total percentage of either T or non-T cells stained by monoclonal anti-Ia Abs. Blocking of anti-Ia Abs binding by SLE sera was not histocompatibility leukocyte antigen (HLA)-DR restricted and was not due to Fc receptor binding. These results indicated that antibodies in SLE sera react with structures contiguous to or identical with Ia determinants. Anti-Ia activities in SLE sera correlate with SLE disease activity. In addition, there was a significant negative correlation between anti-Ia blocking activity in the sera and the percentage of Ia-positive T cells in the blood of SLE patients. Antibodies in SLE sera with anti-Ia blocking activity may play an important role in immune dysregulation in SLE patients.
Airspeed estimation using servo current and aircraft model (2013)

This paper presents a model-based technology for estimating the airspeed of an aircraft. It requires a dynamic model of the aircraft and a measurement of a signal which correlates with the wind load such as the servo current. The performance of the airspeed estimator is evaluated against modeling errors such as uncertainties in aircraft weight and c.g. configuration and errors in the control surface hinge moment coefficients. Simulation experiments show that the airspeed estimation error is comparable with that of a pitot tube for low-mid wind levels (~25-50 knots) with an uncertainty in the aircraft weight up to 19% and in the c.g. location up to 16%, and with typical errors in the control hinge moment coefficients. The estimation error increases by a factor of two for high levels of wind (~100 knots).
Comentario a los aspectos civiles y aseguradores de la sentencia de la audiencia provincial de valencia de 14 de mayo de 2007 (Caso del anestesista Maeso) (2007)

Homeostasis is the net result of a highly balanced network of growth-stimulating and growth-inhibitory signals. We have shown that density-dependent inhibition of growth in vitro is mediated by the interaction of contactinhibin with a 92 kD plasma membrane glycoprotein, CiR, the contactinhibin-binding capacity of which is regulated by phosphorylation.
Factory-level supervision based on real-time cellular object architectures (2002)

An architecture for the supervisory control of flexible production processes at the factory level is introduced. The architecture is based on the idea of concurrent synchronous cellular logic and its extensions in the form of multi-level hierarchical structures. Active cellular objects are used to provide real-time behavioral templates which can be instantiated at any time by translating the formal process specifications given in the form of a colored Petri net. The resulting architecture exhibits high-performance characteristics through its parallel organization and very high flexibility through its modular template-like structure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Characterization of<i>Bacillus</i>and<i>Pseudomonas</i>strains with suppressive traits isolated from tomato hydroponic-slow filtration unit (2007)

Bacillus and Pseudomonas spp. are known to be involved in plant pathogenic fungi elimination during the slow filtration process used in tomato soilless cultures. We isolated 6-8 strains of both Bacillus and Pseudomonas from the top, middle, and bottom sections of filters and identified them after 16S rDNA sequencing. Four Pseudomonas strains were identified as Pseudomonas fulva, 5 as Pseudomonas plecoglossicida, and 12 as Pseudomonas putida. The use of specific oligonucleotide polymerase chain reaction primer sets designed from gyrB gene sequences additionally permitted the identification of 17 Bacillus cereus and 3 Bacillus thuringiensis strains. Ribotyping with EcoRI pointed out an important polymorphism within Bacillus and Pseudomonas strains. Molecular characterization did not reveal a correlation between the location of isolates within the filter (top, middle, or bottom) and bacterial identification or riboclusters. Functional aspects assessed by community-level physiological profiling showed marked phenotypic differences between Pseudomonas communities isolated from the top and bottom filter layers; differences were lower between Bacillus communities of different layers and far less noticeable between mixed communities of Bacillus and Pseudomonas. These strains were tested for several suppressive activities. Conversely to most Bacillus, the majority of Pseudomonas strains were auxin producers and promoted the growth of tomato plantlet roots. On the other hand, only Bacillus strains displayed antagonistic activities by inhibiting the growth of pathogenic fungi frequently detected in soilless cultures. Siderophores were produced by nearly all bacteria, but at higher amounts by Pseudomonas than Bacillus strains. The biocontrol agent potentiality of certain strains to optimize the slow filtration process and to promote the suppressive potential of nutrient solution is discussed.
Modulation of LMP1 protein expression by EBV-encoded microRNAs (2007)

Epstein-Barr virus (EBV) was the first human virus found to encode microRNAs (miRNAs), but the function of these miRNAs has been obscure. Nasopharyngeal carcinoma (NPC) is associated with EBV infection, and the EBV-encoded LMP1 is believed to be a key factor in NPC development. However, detection of LMP1 protein in NPC is variable. Here, we report that EBV-encoded BART miRNAs target the 3' UTR of the LMP1 gene and negatively regulate LMP1 protein expression. These miRNAs also modulate LMP1-induced NF-kappaB signaling and alleviate the cisplatin sensitivity of LMP1-expressing NPC cells. Consistent with a previous study on the NPC C666-1 cell line and C15 xenograft, we found abundant expression of BART miRNAs in NPC tissues. Furthermore, DNA sequencing revealed that the 3' UTR of LMP1 is highly conserved in NPC-derived EBV isolates. The data provide insight into the discrepancy between LMP1 transcript and protein detection in NPC and highlight the role of the EBV miRNAs in regulating LMP1 downstream signaling to promote cancer development.
A wireless measurement system for three-dimensional ocular movement using the magnetic contact lens sensing technique (2005)

A new and innovative method to measure the eye movement in a wireless manner was proposed. We verified the feasibility of our idea by fabrication and performance test of a prototype system. The prototype system consisted of a contact lens with a ring-shaped thin magnet, and eyeglasses frame-shaped PCB with analog/digital signal processing circuitry as well as four magnetoresistive sensors. This new method based on the magnetic contact lens sensing technique (MCLST) is expected to overcome all the disadvantages of the existing techniques.
Analyzing patterns-of-treatment data to provide feedback to physicians. (1994)

Physicians' practice patterns can be influenced through feedback programs. The purpose of this article is to define a methodology that provides the feedback information necessary to affect physicians' practice patterns, using data collected by a large multispecialty physician group and individualized feedback plans for primary care physicians.
Syndecans Serve as Attachment Receptors for Human Immunodeficiency Virus Type 1 on Macrophages (2001)

Macrophages are thought to represent one of the first cell types in the body to be infected during the early stage of human immunodeficiency virus type 1 (HIV-1) transmission and represent a potential viral reservoir in vivo. Thus, an understanding of HIV-1 attachment to these cells is fundamental to the development of novel anti-HIV-1 therapies. Although one of the major targets of HIV-1 in vivo--CD4(+) T lymphocytes--express high CD4 levels, other major targets such as macrophages do not. We asked in this study whether this low CD4 level on macrophages is sufficient to support HIV-1 attachment to these cells or whether cell surface proteins other than CD4 are required for this process. We show that CD4 alone is not sufficient to support the initial adsorption of HIV-1 to macrophages. Importantly, we find that heparan sulfate proteoglycans (HSPGs) serve as the main class of attachment receptors for HIV-1 on macrophages. Most importantly, we demonstrate that a single family of HSPGs, the syndecans, efficiently mediates HIV-1 attachment and represents an abundant class of attachment receptors on macrophages.
Inference about the change-point in a sequence of binomial variables (1970)

The problem of making inferences about the point in a sequence of zero-one variables at which the binomial parameter changes is considered. The asymptotic distribution of the maximum likelihood estimate of the change-point is derived in computable form using random walk- results. The asymptotic distributions of likelihood ratio statistics for testing hypothesis about the change-point are also obtained. Some exact numerical results for these asymptotic distributions are given and their accuracy as finite sample approximations is discussed.
Expression of Integrin Receptors on Plasma Membranes of Primary Corneal Epithelial Cells is Matrix Specific (1997)

Modulation of cell behavior may occur through cell adhesion receptors that bind domains of extracellular matrix molecules and mediate cell-substrate signal transduction. It was hypothesized that while primary corneal epithelial cells seeded onto laminin and fibronectin express and synthesize integrin receptors, they are not detected on the plasma membrane until the appropriate ligand is present. The integrin subunits (alpha-6, beta-4 and beta-1) present on the plasma membrane after adherence to laminin and fibronectin were compared with changes that occurred in mRNA expression and protein synthesis. Prior to seeding, the percentage of cells expressing integrin receptors and matrix proteins on their plasma membrane was determined. Negligible laminin and fibronectin (0-7%) were present on the plasma membrane while the population of epithelial cells expressing beta-4 and beta-1 on the plasma membrane was low (21-23%). After 3 hr of adherence the cell population expressing integrin subunits was substrate dependent. The percentage of cells adherent to LM expressing beta-4 was four-fold greater than cells adherent to FN. After 24 hr the percentage of cells cultured on fibronectin expressing beta-4 increased significantly indicating ligand deposition. The expression and protein synthesis of alpha-6 and beta-4 was evaluated and an increase in the synthesis of alpha-6 and beta-4 was not detected until 18 hr on LM and 21 hr on FN. The present results demonstrate that expression and transport of integrin receptors to the plasma membrane of primary corneal epithelial cells after adhesion is regulated by the presence of specific ligands.
Visualization and identification of health space, based on personalized molecular phenotype and treatment response to relevant underlying biological processes (2012)

The 'health space' model allows visualization of multiple results and to interpret them. The model presents treatment group effects, subgroups and individual responses.
Laser thermal annealed SSR well prior to epi-channel growth (LASPE) for 70 nm nFETS (2002)

Laser thermal annealed super-steep retrograded well prior to epi-channel growth (LASPE) was designed to prevent a severe B loss causing an anomalous V/sub t/ lowering for SSR nFETs, which usually occurred during epi-channel (EC) growth, and to freeze SSR doping profile upon subsequent annealing. Shallow (<50 A) melting by laser thermal annealing (LTA) leads to a backward shift of /spl delta/-type B peak along with increasing peak broadness while suppressing B loss remarkably upon EC growth and RTA. The amount of /spl delta/-peak shift increases with EC thickness, and is found to freeze without further TED upon RTA. Compared to conventional epi-channel devices, improved short channel and junction leakage characteristics with reasonable V, but slightly degraded long-channel S-factor were obtained by employing 70 nm LASPE nFETs. The body effect was also found to be independent of channel width variation, implying no B TED and segregation into the isolation oxide edges.
Oxidation and Fracture Strength of High‐Purity Reaction‐Bonded Silicon Nitride (1989)

Reaction‐bonded Si 3 N 4 (RBSN) made from high‐purity Si powder is unusually resistant to degradation caused by exposures to air for up to 50 h at temperatures up to 1400°C. The weight gain during oxidation of this SiH 4 ‐originating RBSN is approximately 10 times less than conventional RBSN. Contrary to normally observed strength degradations, room‐temperature strengths of this high‐purity, oxidized RBSN (avg = 435 MPa, max. = 668 MPa) remained at their unusually high, as‐processed levels after 1000° and 1400°C oxidizing exposures. Fracture toughness values were unaffected by oxidation ( K IC = 2.3 to 2.4 MPa · m 1/2 ). This superior oxidation resistance results from the high purity and the small diameter pore channels (0.01 to 0.06 μm) achieved in this SiH 4 ‐originating RBSN.
Controlling physics-based characters using soft contacts (2011)

In this paper, we investigate the impact of the deformable bodies on the control algorithms for physically simulated characters. We hypothesize that ignoring the effect of deformable bodies at the site of contact negatively affects the control algorithms, leading to less robust and unnatural character motions. To verify the hypothesis, we introduce a compact representation for an articulated character with deformable soft tissue and develop a practical system to simulate two-way coupling between rigid and deformable bodies in a robust and efficient manner. We then apply a few simple and widely used control algorithms, such as pose-space tracking control, Cartesian-space tracking control, and a biped controller (SIMBICON), to simulate a variety of behaviors for both full-body locomotion and hand manipulation. We conduct a series of experiments to compare our results with the motion generated by these algorithms on a character comprising only rigid bodies. The evaluation shows that the character with soft contact can withstand larger perturbations in a more noisy environment, as well as produce more realistic motion.
Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells. (1986)

Single channel and whole cell recordings were used to study ion permeation through Ca channels in isolated ventricular heart cells of guinea pigs. We evaluated the permeability to various divalent and monovalent cations in two ways, by measuring either unitary current amplitude or reversal potential (Erev). According to whole cell measurements of Erev, the relative permeability sequence is Ca2+ greater than Sr2+ greater than Ba2+ for divalent ions; Mg2+ is not measurably permeant. Monovalent ions follow the sequence Li+ greater than Na+ greater than K+ greater than Cs+, and are much less permeant than the divalents. These whole cell measurements were supported by single channel recordings, which showed clear outward currents through single Ca channels at strong depolarizations, similar values of Erev, and similar inflections in the current-voltage relation near Erev. Information from Erev measurements stands in contrast to estimates of open channel flux or single channel conductance, which give the sequence Na+ (85 pS) greater than Li+ (45 pS) greater than Ba2+ (20 pS) greater than Ca2+ (9 pS) near 0 mV with 110-150 mM charge carrier. Thus, ions with a higher permeability, judged by Erev, have lower ion transfer rates. In another comparison, whole cell Na currents through Ca channels are halved by less than 2 microM [Ca]o, but greater than 10 mM [Ca]o is required to produce half-maximal unitary Ca current. All of these observations seem consistent with a recent hypothesis for the mechanism of Ca channel permeation, which proposes that: ions pass through the pore in single file, interacting with multiple binding sites along the way; selectivity is largely determined by ion affinity to the binding sites rather than by exclusion by a selectivity filter; occupancy by only one Ca ion is sufficient to block the pore's high conductance for monovalent ions like Na+; rapid permeation by Ca ions depends upon double occupancy, which only becomes significant at millimolar [Ca]o, because of electrostatic repulsion or some other interaction between ions; and once double occupancy occurs, the ion-ion interaction helps promote a quick exit of Ca ions from the pore into the cell.
Direct growth of aligned carbon nanotube field emitter arrays onto plastic substrates (2003)

The direct growth of vertically aligned carbon nanotubes onto flexible plastic substrates using plasma-enhanced chemical vapor deposition is reported. We show that individual lines and dots of free-standing 20–50 nm diameter nanotubes can be grown onto chromium covered commercially available polyimide foil. The scalable deposition method allows large area coverage without degrading or bending the sensitive substrate material. Field emission measurements show a low turn-on field (3.2 V/μm) and a low threshold field (4.2 V/μm). The result establishes a method of flexible field emitter fabrication, which is well suited for display production and integration of nanotubes into plastic electronics.
Design of Low-Complexity Convolutional Codes over GF(q) (2018)

This paper proposes a new family of recursive systematic convolutional codes, defined in the non-binary domain over different Galois fields GF(q) and intended to be used as component codes for the design of non-binary turbo codes. A general framework for the design of the best codes over different GF(q) is described. The designed codes offer better performance than the non-binary convolutional codes found in the literature. They also outperform their binary counterparts when combined with their corresponding QAM modulation or with lower order modulations.
Synthesis and Properties of New Stacked Metallocene Polymers (1999)

The substituted cyclopentadienes 5a,b are readily prepared in two steps from benzyloxybenzaldehyde and 4-dimethylaminobenzaldehyde by condensation with cyclopentadiene followed by lithium aluminum hydride reduction of the fulvenes 4a,b. Coupling of the zinc salts of 5a,b with 1,8-diiodonaphthalene in the presence of a catalytic amount of CuI gives the cyclopentadienylated iodonaphthalenes 6a,b. This new protocol represents a significant improvement over earlier procedures for the preparation of such compounds. Conversion of 6a,b to the ferrocenes 7a,b, followed by a second cyclopentadienylation step, affords 8a,b or 9a. These serve as monomers for the synthesis of polymers 1d,e and copolymers 1f−h. These materials show increased molecular weights and improved solubility compared with 1b,c and analogues, in which the cyclopentadienyl-ring substituents are alkyl chains.
Implementation of the ebXML registry client for the ebXML registry services (2003)

The implementation of the ebXML registry services is a part of a research project at the University of Zagreb, aimed at defining a strategy for the adoption of e-business in Croatia. Implementing the ebXML registry/repository is a vital step as it implements a standard mechanism for registering, storing and retrieving data about business partners relevant for conducting e-business. This paper describes an implementation of the ebXML registry client as a diagnostic tool to test and debug the ebXML registry/repository implementation under development. The client can generate arbitrary submit objects requests to the registry services. It guarantees the conformance of the requests with the OASIS/ebXML registry services specification.
Acoustic impedance matching of piezoelectric transducers to the air (2004)

The purpose of this work is threefold: to investigate material requirements to produce impedance matching layers for air-coupled piezoelectric transducers, to identify materials that meet these requirements, and to propose the best solution to produce air-coupled piezoelectric transducers for the low megahertz frequency range. Toward this end, design criteria for the matching layers and possible configurations are reviewed. Among the several factors that affect the efficiency of the matching layer, the importance of attenuation is pointed out. A standard characterization procedure is applied to a wide collection of candidate materials to produce matching layers. In particular, some types of filtration membranes are studied. From these results, the best materials are identified, and the better matching configuration is proposed. Four pairs of air-coupled piezoelectric transducers also are produced to illustrate the performance of the proposed solution. The lowest two-way insertion loss figure is -24 dB obtained at 0.45 MHz. This increases for higher frequency transducers up to -42 dB at 1.8 MHz and -50 at 2.25 MHz. Typical bandwidth is about 15-20%.