gebhart/patrepeval huggingface dataset:
A Real-time FFT Based Block Processing Method with Near Linear Scaling (2015)

Block processing algorithms have great potential in GNSS receivers. The block processing methods considered here are based on the Fourier correlation method which generates the full correlation function. Historically the large processing power requirements of FFT have prevented these block processing methods being used outside the acquisition phase. This paper presents an algorithm which reduces the processing requirements of FFT-based block processing for GNSS signals by an order of magnitude compared to current techniques.

The Multiple Tracking Locked Loop (MTLL) FFT algorithm presented here in the limit of long integration times (circa 20ms or longer) and multiple tracked satellites (circa 10) scales near-linearly with sample rate. The MTLL method can be applied to GPS and Galileo signals and still exhibits its near-linear scaling with either signal constellation.

As the MTLL algorithm gives access to the full correlation function further post processing can be done to completely mitigate multipath, where there is line of sight to the satellite and its ability to remove multipath effects is only limited by the initial RF sampling bandwidth. The MTLL method also lends itself to the detection and mitigation of interference as it is based on performing FFTs.

The method lends itself to long integration times and can be easily implemented on standard computer hardware. This allows very high sensitive receivers that operate in difficult conditions like indoors, urban environments and under fading due to scintillation. 

This paper defines the algorithm and the underlying principles, describes how the tracking algorithm works and how it has been implemented in a software receiver using standard commercial computer hardware. Early results of experiments done using GPS and Galileo constellations are also presented.
The Langmuir‐Blodgett Approach to Making Colloidal Photonic Crystals from Silica Spheres (2010)

The area of colloidal photonic crystal research has attracted enormous attention in recent years as a result of the potential of such materials to provide the means of fabricating new or improved photonic devices. As an area where chemistry still predominates over engineering the field is still in its infancy in terms of finding real applications being limited by ease of fabrication, reproducibility and 'quality'- for example the extent to which ordered structures may be prepared over large areas. It is our contention that the Langmuir-Blodgett assembly method when applied to colloidal particles of silica and perhaps other materials, offers a way of overcoming these issues. To this end the assembly of silica and other particles into colloidal photonic crystals using the Langmuir-Blodgett (LB) method is described and some of the numerous papers on this topic, which have been published, are reviewed. It is shown that the layer-by-layer control of photonic crystal growth afforded by the LB method allows for the fabrication of a range of novel, layered photonic crystals that may not be easily assembled using any other approach. Some of the more interesting of these structures, including so-called heterostructured photonic crystals comprising of layers of spheres having different diameters are presented and their optical properties described. Finally, we offer our comments as to future applications of this interesting technology.
Malicious Cryptology and Mathematics (2012)

Malicious cryptology and malicious mathematics is an emerging domain initiated in Filiol & Josse (2007); Filiol & Raynal (2008;b).It draws its inspiration from crypto virology Young & Yung (2004).However this latter domain has a very limited approach of how cryptography can be perverted by malware.Indeed, their authors consider the case of extortion malware in which asymmetric cryptography is only used inside a malware payload to extort money in exchange of the secret key necessary to recover the file encrypted by the malware (e.g. a computer virus).Malicious cryptology and malicious mathematics make in fact explode Young and Yung's narrow vision.This results in an unlimited, fascinating yet disturbing field of research and experimentation.This new domain covers several fields and topics (non-exhaustive list):• Use of cryptography and mathematics to develop "super malware"( über-malware) which evade any kind of detection by implementing:-Optimized propagation and attack techniques (e.g. by using biased or specific random number generator) Filiol et al. (2007).-Sophisticated self-protection techniques.The malware code protects itself and its own functional activity by using strong cryptography-based tools Filiol (2005b).-Sophisticated auto-protection and code armouring techniques.Malware protect their own code and activity by using strong cryptography.-Partial or total invisibility features.The programmer intends to make his code to become invisible by using statistical simulability Filiol & Josse (2007).• Use of complexity theory or computability theory to design undetectable malware.• Use of malware to perform cryptanalysis operations (steal secret keys or passwords), manipulate encryption algorithms to weaken them on the fly in the target computer memory.The resulting encryption process will be easier to be broken Filiol (2011).• Design and implementation of encryption systems with hidden mathematical trapdoors.The knowledge of the trap (by the system designer only) enables to break the system very efficiently.Despite the fact that the system is open and public, the trapdoor must remain undetectable.This can also apply to the keys themselves in the case of asymmetric cryptography Erra & Grenier (2009).
Phospholipase C-β1 Directly Accelerates GTP Hydrolysis by Gαq and Acceleration Is Inhibited by Gβγ Subunits (1999)

Phospholipase C-beta, the principal effector protein regulated by Galphaq, has been shown to increase the agonist-stimulated, steady-state GTPase activity of Gq in proteoliposomes that contain both heterotrimeric Gq and m1 muscarinic receptor. We now use a moderately stable complex of R183C Galphaq bound to GTP to show that PLC-beta1 acts directly as a GTPase-activating protein (GAP) for isolated Galphaq in a membrane-free system. PLC-beta1 accelerated the hydrolysis of GalphaqR183C.GTP up to 20-fold. The Km was 1.5 nM, which is similar both to the EC50 with which R183C and wild type Galphaq activate PLC-beta1 and to the EC50 with which PLC-beta1 acts as a Gq GAP in the vesicle-based assay. The Galphaq GAP activity of RGS4 can also be quantitated by this assay; it accelerated hydrolysis of bound GTP about 100-fold. The Gq GAP activities of both PLC-beta1 and RGS4 are blocked by Gbeta gamma subunits, probably by a competitive mechanism. These data suggest either that the Gbeta gamma subunits are not continuously required for receptor-catalyzed GDP/GTP exchange during steady-state GTP hydrolysis or that GAPs, either PLC-beta or RGS proteins, can substitute for Gbeta gamma in this set of reactions.
Structure of Plumbemycin A and B, Antagonists of<scp>l</scp>-Threonine from<i>Streptomyces plumbeus</i> (1977)

The structure of plumbemycin A and B, new antimetabolites from Streptomyces plumbeus, which are antagonist of l-threonine, were assigned to be l-alanyl-l-aspartyl-d-2-amino-5-phosphono-3-czs-penten...
Overproduction of γ-Linolenic and Eicosapentaenoic Acids by Algae (1992)

The pharmaceutical interest and limited availability of gamma-linolenic acid (GLA) and eicosapentaenoic acid (EPA) prompted the search for genetic means for increasing the production of these fatty acids from algal sources. Cell lines of Spirulina platensis and Porphyridium cruentum resistant to the growth inhibition of the herbicide Sandoz 9785 were selected by serial transfers of the culture in the presence of increasing concentrations of the herbicide. The resistant cell lines of S. platensis overproduced GLA and those of P. cruentum overproduced EPA and were stable for at least 50 generations in the absence of the inhibitor.
Epidermal growth factor receptor expression in mice skin upon ultraviolet B exposure - Seborrheic Keratosis as a coincidental and unique finding (2012)

UVB led to Seborrheic Keratosis (SK) in mice through enhancement of EGFR expression. Antioxidants effectively reduced UVB-induced SK, reduced epidermal changes, apoptotic bodies, and decreased dermal mast cells. TAS measurement declined in exposure group, while it was within normal range in most treated cases.
Temperature dependence of the electrical conductivity of potassium-doped polyacetylene as a function of pressure and magnetic field (1993)

The effects of pressure and magnetic field on the electrical conductivity (\ensuremath{\sigma}) of oriented polyacetylene highly doped to the metallic state with potassium, K-(CH${)}_{\mathit{x}}$, has been investigated. The conductivity at 10 kbar is greater than that at ambient pressure by a factor of two, and the temperature dependence is substantially weaker. The power-law temperature dependence of conductivity at ambient pressure, \ensuremath{\sigma}(T)\ensuremath{\propto}${\mathit{T}}^{0.57}$, implies that K-(CH${)}_{\mathit{x}}$ is in the critical regime near the metal-insulator boundary. At 10 kbar, \ensuremath{\sigma}(T) becomes nearly temperature independent at low temperatures, consistent with pressure driving the system toward a transition into the metallic state. At ambient pressure, it is possible to localize the wave functions of the states near the Fermi level by an external magnetic field; at high fields \ensuremath{\sigma}(T) crosses over from the power-law to the exp(-${\mathit{T}}^{\mathrm{\ensuremath{-}}1/4}$) dependence characteristic of variable range hopping between localized states. Thus, increased pressure tends to delocalize the electronic wave functions, whereas high magnetic fields tend to localize the electronic wave functions.
Relaxed Negative Selection in Germinal Centers and Impaired Affinity Maturation in <i>bcl-x</i>L Transgenic Mice (1999)

The role of apoptosis in affinity maturation was investigated by determining the affinity of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific antibody-forming cells (AFCs) and serum antibody in transgenic mice that overexpress a suppressor of apoptosis, Bcl-xL, in the B cell compartment. Although transgenic animals briefly expressed higher numbers of splenic AFCs after immunization, the bcl-xL transgene did not increase the number or size of germinal centers (GCs), alter the levels of serum antibody, or change the frequency of NP-specific, long-lived AFCs. Nonetheless, the bcl-xL transgene product, in addition to endogenous Bcl-xL, reduced apoptosis in GC B cells and resulted in the expansion of B lymphocytes bearing VDJ rearrangements that are usually rare in primary anti-NP responses. Long-lived AFCs bearing these noncanonical rearrangements were frequent in the bone marrow and secreted immunoglobulin G(1) antibodies with low affinity for NP. The abundance of noncanonical cells lowered the average affinity of long-lived AFCs and serum antibody, demonstrating that Bcl-xL and apoptosis influence clonal selection/maintenance for affinity maturation.
<i>SULT1A1</i> polymorphism and esophageal cancer in males (2002)

Sulfotransferase (SULT) 1A1 detoxifies and bioactivates a broad spectrum of substrates including xenobiotics. It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G-->A transition at codon 213, carries a significantly higher risk for women to develop breast cancer. We investigated the association between the SULT1A1 arg/his genotype and esophageal cancer in men, 187 cases of esophageal squamous cell carcinoma and 308 controls from 3 medical centers in Taiwan. Cigarette smoking, areca chewing and alcohol consumption were the major risks for developing esophageal cancer. The frequencies of arg/his in cases and controls were 27.8% (52/187) and 11.0% (34/308), respectively (p < 0.0001). No subjects carried his/his. After adjusting for substance use and other covariates, individuals with arg/his had a 3.53-fold higher risk (95% CI = 2.12-5.87) of developing esophageal cancer than those with arg/arg. Unexpectedly, this positive association was found to be even stronger (adjusted OR = 4.04-4.80) among non-smokers, non-drinkers or non-chewers. Our findings suggest that the SULT1A1 his(213) allele is important in the development of esophageal cancer in men.
An internet accessible remote controlled home automation system (1997)

Home automation systems have been in development since the late seventies. However, the home automation market has not fully reached its potential. This can be attributed to a number of factors. Remote home automation systems, however, are quickly becoming more and more popular. Users like the ability to change their home environment while not at home. The remote home automation systems in existence, however, use the telephone as a medium for communication. These telephone user interfaces, unfortunately, are crude at best and often lead to a frustrating attempt to access the system. A better system would be one that could offer a graphical user interface, such as a homepage on the internet. Thus, if the user can access a web browser, the user can access the home automation system. In this paper, we discuss the design and implementation of such a system, an Internet Accessible Remote-control Home Automation System.
Cytokinin Production by <i>Bradyrhizobium japonicum</i> (1989)

Although there is considerable circumstantial evidence for the involvement of cytokinins in legume nodulation, the cytokinins produced by rhizobia have not been well characterized. Bradyrhizobium japonicum 61A68, a bacterium which nodulates soybean (Glycine max [L.] Merr.), was grown in defined medium. Cytokinins were purified from the culture medium by Amberlite XAD-2 chromatography and fractionated by column chromatography on Sephadex LH-20 in 35% ethanol. Pooled fractions from the Sephadex column were analyzed for cytokinin activity with the tobacco callus bioassay. Cytokinin activity was observed in fractions corresponding to the elution volumes of zeatin, ribosylzeatin, and methylthiozeatin. No activity corresponding to the elution volumes of isopentenyladenine or its riboside was found. Total cytokinin activity in the B. japonicum culture filtrate was equivalent to approximately 1 microgram of kinetin per liter. Transfer RNA was isolated from B. japonicum cells by phenol extraction, followed by potassium acetate extraction, cetyltrimethylammonium bromide precipitation, and DEAE cellulose chromatography. Transfer RNA was enzymically hydrolyzed to nucleosides. High performance liquid chromatographic analysis of cytokinin nucleosides showed peaks corresponding to the retention times of trans-ribosylzeatin, methylthioribosylzeatin, isopentenyladenosine, and methylthioisopentenyladenosine. Analysis of the tRNA hydrolysate by Sephadex LH-20 chromatography and tobacco bioassay showed cytokinin activity in fractions corresponding to ribosylzeatin, methylthioribosylzeatin, and isopentenyladenosine. The presence of the trans isomer of ribosylzeatin was also determined by enzyme immunoassay.
Oligothiophene-<i>S</i>,<i>S</i>-dioxides:  a New Class of Thiophene-based Materials (1998)

We report here that bissilylated oligothiophenes may be selectively oxidized at the thienyl sulfurs by m-chloroperbenzoic acid (m-CPBA) to afford stable S,S-dioxides having alternate aromatic and nonaromatic moieties. These compounds are characterized by enhanced electron delocalization, smaller optical gap, and greater electron affinity than the “fully aromatic” precursors.
[Impact of exogenic proteolytic enzymes on bacteria]. (2004)

The impact of papain, trypsin and the enzyme complex vobenzyme on formation of biofilms by grampositive and gramnegative bacteria was studied. The enzymes were shown to inhibit the biofilm formation. When applilied to the formed associations, the enzymes potentiated the effect of antibiotics on the bacteria located in them. An increase in the antimicrobial effect of various nonrelated antibiotics was not connected with a change in the bacteria susceptibility but likely resulted from higher bioavailability of the drugs in the presence of the enzymes.
A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture (2015)

Clustered regularly interspaced short palindromic repeat (CRISPR) RNA-guided nucleases have gathered considerable excitement as a tool for genome engineering. However, questions remain about the specificity of target site recognition. Cleavage specificity is typically evaluated by low throughput assays (T7 endonuclease I assay, target amplification followed by high-throughput sequencing), which are limited to a subset of potential off-target sites. Here, we used ChIP-seq to examine genome-wide CRISPR binding specificity at gRNA-specific and gRNA-independent sites for two guide RNAs. RNA-guided Cas9 binding was highly specific to the target site while off-target binding occurred at much lower intensities. Cas9-bound regions were highly enriched in NGG sites, a sequence required for target site recognition by Streptococcus pyogenes Cas9. To determine the relationship between Cas9 binding and endonuclease activity, we applied targeted sequence capture, which allowed us to survey 1200 genomic loci simultaneously including potential off-target sites identified by ChIP-seq and by computational prediction. A high frequency of indels was observed at both target sites and one off-target site, while no cleavage activity could be detected at other ChIP-bound regions. Our results confirm the high-specificity of CRISPR endonucleases and demonstrate that sequence capture can be used as a high-throughput genome-wide approach to identify off-target activity.
A Parallel Phase I/II Clinical Trial Design for Combination Therapies (2006)

The use of multiple drugs in a single clinical trial or as a therapeutic strategy has become common, particularly in the treatment of cancer. Because traditional trials are designed to evaluate one agent at a time, the evaluation of therapies in combination requires specialized trial designs. In place of the traditional separate phase I and II trials, we propose using a parallel phase I/II clinical trial to evaluate simultaneously the safety and efficacy of combination dose levels, and select the optimal combination dose. The trial is started with an initial period of dose escalation, then patients are randomly assigned to admissible dose levels. These dose levels are compared with each other. Bayesian posterior probabilities are used in the randomization to adaptively assign more patients to doses with higher efficacy levels. Combination doses with lower efficacy are temporarily closed and those with intolerable toxicity are eliminated from the trial. The trial is stopped if the posterior probability for safety, efficacy, or futility crosses a prespecified boundary. For illustration, we apply the design to a combination chemotherapy trial for leukemia. We use simulation studies to assess the operating characteristics of the parallel phase I/II trial design, and compare it to a conventional design for a standard phase I and phase II trial. The simulations show that the proposed design saves sample size, has better power, and efficiently assigns more patients to doses with higher efficacy levels.
Effect of Heterocyclic and Other Thiosemicarbazones on Vaccinia Infection in the Mouse (1953)

Summary Thiosemicarbazones containing benzene, thiophene, pyridine, quinoline or isatin groups have been demonstrated to protect mice against vaccinia virus. Protection is obtained when the virus is given by the cerebral route and compounds fed in the diet. The =N-NH-CS-NH2 group, as such, appears to be essential for antivaccinal activity. Semicarbazones of benzaldehyde, 2-thenaldehyde, cinchoninaldehyde and isatin were devoid of protective capacity. The presence of an aldehyde structure with attachment of the thiosemicarbazone moiety to the aldehyde carbon atom contributes to antiviral capacity but is not essential for this property. Substitutions on the aldehyde carbon atom reduced or abolished protective action of compounds. Substitution in the ring protion of the molecule produced the same result except in p-nitro and o-methoxy benzaldehyde and 5-chloro, 5-bromo and 3-methyl-2-thenaldehyde derivatives. Thiosemicarbazones with high antivaccinal activity in mouse embryonic tissues may fail to protect mice against the virus.
Gold Salts in the Treatment of Rheumatoid Arthritis (1974)

A 2-year double-blind study was made of gold salt treatment in 27 patients who had active rheumatoid arthritis for less than 5 years. The gold salt (gold sodium thiomalate) was well tolerated in 13 of 15 patients. Improvement, measured by physical examination, ring sizes, and grip strength, was significant in the treated group. Radiologic examination showed that the bone and cartilage destruction was arrested in several patients, and the mean progression rate of destruction was significantly slowed for the treated group.
Joseph J. Geary (1959)

News| June 01 1959 Joseph J. Geary Brantley M. Eubanks Brantley M. Eubanks Search for other works by this author on: This Site PubMed Google Scholar California Historical Society Quarterly (1959) 38 (2): 180. https://doi.org/10.2307/25155255 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Brantley M. Eubanks; Joseph J. Geary. California Historical Society Quarterly 1 June 1959; 38 (2): 180. doi: https://doi.org/10.2307/25155255 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentCalifornia History Search This content is only available via PDF. Copyright 1959 The California Historical Society Article PDF first page preview Close Modal You do not currently have access to this content.
Rapid suppression of complex ventricular arrhythmias with high-dose oral amiodarone. (1986)

Although amiodarone is effective for the suppression of complex ventricular arrhythmias, a major problem with its use is the long delay between the initiation of therapy and the onset of effective suppression of arrhythmia. To test the hypothesis that rapid loading with oral amiodarone to a target serum concentration can overcome much of this delay, eight patients with refractory, sustained, hemodynamically compromising ventricular arrhythmias and 10 patients with potentially life-threatening ventricular arrhythmias were treated with a flexible, very high dose, oral loading protocol (800 to 2000 mg two to three times a day). Dosage was adjusted on the basis of amiodarone serum concentrations to maintain the trough serum concentrations between 2.0 and 3.0 micrograms/ml. Comparison of 24 hr Holter electrocardiograms obtained before and during therapy revealed statistically significant reductions in premature ventricular complexes (PVCs) and paired PVCs beginning the first day of therapy and a reduction in v...
The Role of Pathology in an Investigation of an Outbreak of West Nile Encephalitis in New York, 1999 (2000)

An outbreak of encephalitis occurred in New York City in late August 1999, the first caused by West Nile virus in North America. Histopathologic and immunopathologic examinations performed on human autopsy materials helped guide subsequent laboratory and epidemiologic investigations that led to identification of the etiologic agent.