gebhart/patrepeval huggingface dataset:
Impact of incomplete metal coverage on the electrical properties of metal-CNT contacts: A large-scale <i>ab initio</i> study (2016)

Using a dedicated combination of the non-equilibrium Green function formalism and large-scale density functional theory calculations, we investigated how incomplete metal coverage influences two of the most important electrical properties of carbon nanotube (CNT)-based transistors: contact resistance and its scaling with contact length, and maximum current. These quantities have been derived from parameter-free simulations of atomic systems that are as close as possible to experimental geometries. Physical mechanisms that govern these dependences have been identified for various metals, representing different CNT-metal interaction strengths from chemisorption to physisorption. Our results pave the way for an application-oriented design of CNT-metal contacts.
PREPARATION OF POLYMERS WITH SULFILIMINE STRUCTURE (1974)

Abstract The reaction of poly(p-vinylbenzylalkyl sulfide) and poly(p-vinylbenzylphenyl sulfide) with chloramine-T afforded polymers with pendant groups of sulfilimine structure. The same polymers were obtained by radical polymerization of N-tosyl-S-alkyl- and N-tosyl-S-phenyl-S-p-vinylbenzylsulfilimines.
Synthesis of acidic vinylcyclopropanes for dental applications (2017)

Abstract The multistep synthesis of four new acidic vinylcyclopropanes is described. These monomers were fully characterized using 1 H NMR, 13 C NMR and 31 P NMR spectroscopy and high‐resolution mass spectrometry. The homopolymerization of the corresponding polymerizable di‐ tert ‐butyl phosphates as well as the copolymerization of each acidic monomer with 1,1‐diethoxycarbonyl‐2‐vinylcyclopropane were investigated using photo‐differential scanning calorimetry with bis(4‐methoxybenzoyl)diethylgermane as photoinitiator. Self‐etch adhesives based on the synthesized acidic vinylcyclopropanes are able to achieve a strong bond between a dental composite and both dentin and enamel. Flowable composites containing these acidic vinylcyclopropanes exhibit good mechanical properties. The replacement of methacrylates by vinylcyclopropanes leads to a significant reduction of the shrinkage stress of flowable composites. © 2017 Society of Chemical Industry
Designing a Failure-Tolerant Workspace for Kinematically Redundant Robots (2014)

Kinematically redundant manipulators are inherently more robust to locked joint failures than non-redundant manipulators. However, if poorly designed, performance degradation may still occur in the presence of a single locked joint. This paper presents a technique for designing a desired operating workspace for a kinematically redundant manipulator that can be guaranteed after the occurrence of an arbitrary single locked joint failure. The existence of such a workspace, called a failure-tolerant workspace, will be guaranteed by imposing a suitable set of artificial joint limits prior to a failure. Conditions are presented that characterize end-effector locations within the failure-tolerant region. Based on these conditions, an algorithm for computing the failure-tolerant workspace is presented. The algorithm is based upon identifying the boundaries of the failure-tolerant workspace. Examples are presented to illustrate the application of the proposed algorithm to various manipulator design problems.
A Pharmacokinetic Study of Intravenous Itraconazole Followed by Oral Administration of Itraconazole Capsules in Patients with Advanced Human Immunodeficiency Virus Infection (1998)

A randomized, open-label, comparative study was conducted in 30 male patients with moderately advanced human immunodeficiency virus (HIV) infection to examine the pharmacokinetics of an investigational intravenous preparation of itraconazole compared with pharmacokinetics after administration of itraconazole capsules. The study also assessed whether adequate plasma concentrations of itraconazole could be rapidly achieved with the intravenous formulation and then maintained after cessation of intravenous therapy with itraconazole capsules. All patients received 200 mg intravenous itraconazole as a 1-hour infusion in 40% hydroxypropyl-beta-cyclodextrin (HP-beta-CD) vehicle twice daily for 2 days, and then 200 mg intravenously once daily for 5 days. Patients then received itraconazole capsules, either 200 mg twice daily or 200 mg once daily for 28 days. Steady-state plasma concentrations of itraconazole were reached by day 3 with intravenous infusion, a much shorter time than observed with administration of itraconazole capsules. Steady-state concentrations of itraconazole and hydroxyitraconazole were effectively maintained during the rest of the intravenous infusions of itraconazole. Oral follow-up with administration of 200-mg capsules once daily could not maintain the plasma concentrations of itraconazole and hydroxyitraconazole obtained at the end of the intravenous treatment, whereas twice-daily oral administration maintained or increased these concentrations. Mean plasma concentrations of itraconazole and hydroxyitraconazole on day 7 were similar to those on day 36 in the twice-daily group. Mean renal clearance was comparable to mean total body clearance, and approximately 93% to 101% of the HP-beta-CD was excreted unchanged in urine within 12 hours of administration. The HP-beta-CD was essentially eliminated through the kidney, and little accumulation in the body was observed in this patient population. Adverse events during the intravenous phase were most commonly associated with intravenous administration. Intravenous infusion of itraconazole for 7 days followed by administration of itraconazole capsules twice daily for 28 days is an effective dose regimen in patients with advanced HIV infection.
Alternative splicing of CaV2 genes and their functional significance. (2003)

Alternative splicing is one of the most pharmacologically and physiologically significant mechanisms for the functional diversity of the mammalian genomes. Here I review recent results on the diversity of the Ca(v)2 subclass of voltage-dependent Ca(2+) channel gene in neurons. Although the entire picture of alternative splicing is not yet understood, emerging evidences suggest the Ca(v)2 isoforms permit optimization of Ca(2+) signaling in different regions of the brain with specific pharmacological ligands.
Semi-Supervised Graph-Based Hyperspectral Image Classification (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper presents a semi-supervised graph-based method for the classification of hyperspectral images. The method is designed to handle the special characteristics of hyperspectral images, namely, high-input dimension of pixels, low number of labeled samples, and spatial variability of the spectral signature. To alleviate these problems, the method incorporates three ingredients, respectively. First, being a kernel-based method, it combats the curse of dimensionality efficiently. Second, following a semi-supervised approach, it exploits the wealth of unlabeled samples in the image, and naturally gives relative importance to the labeled ones through a graph-based methodology. Finally, it incorporates contextual information through a full family of composite kernels. Noting that the graph method relies on inverting a huge kernel matrix formed by both labeled and unlabeled samples, we originally introduce the NystrÖm method in the formulation to speed up the classification process. The presented semi-supervised-graph-based method is compared to state-of-the-art support vector machines in the classification of hyperspectral data. The proposed method produces better classification maps, which capture the intrinsic structure collectively revealed by labeled and unlabeled points. Good and stable accuracy is produced in ill-posed classification problems (high dimensional spaces and low number of labeled samples). In addition, the introduction of the composite-kernel framework drastically improves results, and the new fast formulation ranks almost linearly in the computational cost, rather than cubic as in the original method, thus allowing the use of this method in remote-sensing applications. </para>
A 40nm 4-downlink and 2-uplink RF Transceiver Supporting LTE-Advanced Carrier Aggregation (2018)

A multi-band multi-mode LTE-Advanced (LTE-A) transceiver is demonstrated in this paper. There are 4 receivers (RX) to support inter-band and intra-band downlink (DL) carrier aggregation (CA) with 256QAM modulation. The RX noise figure (NF) is better than 2.5 dB for RF frequencies < 2.7 GHz and the NF is 3.5 dB in the 5 GHz band. In addition, there are two transmitters (TX) to support inter-band and intra-band uplink (UL) CA with 64QAM modulation. The TX EVM is 1.59% in the 3.5 GHz band. The system architecture and circuit techniques to overcome the 4RX/2TX CA spurs and interferences are described in this paper. It is shown that there is no unwanted CA spur in the signal bandwidth.
Sustained attention in patients with mild traumatic brain injury (2005)

These findings suggest that the SART and Monotone Counting Test are sensitive to patients with mild TBI. The SART-assessed sustained attention is also sensitive enough to detect attention impairment in this clinical group regardless of diagnosis and may provide clinicians with an alternative method of assessing sustained attention in these clinical groups.
Metabolism of phytol to phytanic acid in the mouse, and the role of PPARα in its regulation (2006)

Phytol, a branched-chain fatty alcohol, is the naturally occurring precursor of phytanic and pristanic acid, branched-chain fatty acids that are both ligands for the nuclear hormone receptor peroxisome proliferator-activated receptor alpha (PPARalpha). To investigate the metabolism of phytol and the role of PPARalpha in its regulation, wild-type and PPARalpha knockout (PPARalpha-/-) mice were fed a phytol-enriched diet or, for comparison, a diet enriched with Wy-14,643, a synthetic PPARalpha agonist. After the phytol-enriched diet, phytol could only be detected in small intestine, the site of uptake, and liver. Upon longer duration of the diet, the level of the (E)-isomer of phytol increased significantly in the liver of PPARalpha-/- mice compared with wild-type mice. Activity measurements of the enzymes involved in phytol metabolism showed that treatment with a PPARalpha agonist resulted in a PPARalpha-dependent induction of at least two steps of the phytol degradation pathway in liver. Furthermore, the enzymes involved showed a higher activity toward the (E)-isomer than the (Z)-isomer of their respective substrates, indicating a stereospecificity toward the metabolism of (E)-phytol. In conclusion, the results described here show that the conversion of phytol to phytanic acid is regulated via PPARalpha and is specific for the breakdown of (E)-phytol.
A PEN-BASED MUSICAL SCORE EDITOR (2005)

We present in this paper a pen-based musical score editor prototype. It allows the user to edit quite the same way as if it was on a sheet of paper, all of his drawing strokes being progressively recognized and replaced by their corresponding symbol by the system, right during the editing. Most of the classical musical symbols are already available, as well as the basic editing possibilities. We propose a new way to recognize the musical symbols thanks to the knowledge of musical structure, graphically represented by boxes. Finding the structural box in which a stroke is drawn reduces the possible symbols. It helps minimizing ambiguities and increases recognition rates. First tests among musicians are satisfactory and encouraging. 1.
Initial Characterization of an <sup>18</sup>F-Labeled Myocardial Perfusion Tracer (2008)

The observation of a high and flow-independent first-pass extraction fraction promises linearity between tracer uptake and myocardial blood flow. Sustained myocardial tracer uptake, combined with high image contrast, will allow for imaging protocols with tracer injection at peak exercise followed by delayed imaging. Thus, 18F-BMS-747158-02 is a promising new tracer for the quantitative imaging of myocardial perfusion and can be distributed to imaging laboratories without a cyclotron.
The Impacts of ERCC1 Gene Exon VIII Alternative Splicing on Cisplatin-Resistance in Ovarian Cancer Cells (2009)

Excision repair cross complementation group-1 (ERCC1) was reported to be responsible for drug resistance during cancer treatment. In this report, we first proved the existence of ERCC1 exon VIII alternative splicing in ovarian cancer cells. Further investigation showed that over-expressed exon VIII deficient ERCC1 variant failed to change the protein level of ERCC1 in cancer cells, but decreased the excision repair function of ERCC1 and enhanced sensitivity of cancer cells to cisplatin in a dose-dependent manner. The results indicate that ERCC1 exon VIII alternative splicing does exist in some ovarian cancer cell lines, and regulates cisplatin-resistance in ovarian cancer cells.
Quality assessment of packaged foods by optical oxygen sensing (2005)

A phase-fluorometric oxygen sensor system has been developed, which allows non-destructive measurement of residual oxygen levels in sealed containers such as packaged foods. It operates with disposable solid-state sensors incorporated in each pack, and a portable detector which interrogates with the sensors through a (semi)transparent packaging material. The system has been optimized for packaging applications and validated in small and medium scale trials with different types of food, including MAP hams, cheese, convenience foods, smoked fish, bakery. It has demonstrated high efficiency in monitoring package integrity, oxygen profiles in packs, performance of packaging process and many other research and quality control tasks, allowing control of 100% of packs. The low-cost batch-calibrated sensors have demonstrated reliability, safety, stability including direct contact with food, high efficiency in the low oxygen range. Another system, which also employs the fluorescence-based oxygen sensing approach, provides rapid assessment of microbial contamination (total viable counts) in complex samples such as food homogenates, industrial waste, environmental samples, etc. It uses soluble oxygen-sensitive probes, standard microtitter plates and fluorescence measurements on conventional plate reader to monitor growth of aerobic bacteria in small test samples (e.g. food homogenates) via their oxygen respiration. The assay provides high sample through put, miniaturization, speed, and can serve as alternative to the established methods such as agar plate colony counts and turbidimetry.
<title>Automatic Detection Of Microaneurysms In Retinopathy Fluoro-Angiogram</title> (1984)

A computerized method for detecting microaneurysms is described, based upon the concepts introduced by the Mathematical Morphology. On the grey level image of a fluoroangiogram, magnified by a microscope, a first transformation, searching the regional minima, gives a binary image where appear vessels and microaneurysms. Then the microaneurysms are extracted using a shape criterion which selects almost circular particles among stretched particles in one direction. The most complex part is to discriminate diffusing microaneurysm (leakage of fluorescein) from vessel. The algorithm is tested on 25 angiograms. We obtain a good correlation between the automatic counting and the manual counting performed by three reading-technicians.
Outcome of Early-Onset Sepsis in a National Cohort of Very Low Birth Weight Infants (2010)

Although only 2.4% of VLBW infants had an episode of EOS, these infants were at an approximately threefold excess risk of death or major neurologic morbidities.
Preparation, Characterization and Stabilization of Nano- sized Copper Particles (2012)

Abstract: Cu nanoparticles dispersed in water were prepared by the reduction of Cu +2 originated from the copper salt solution. The stability of the Cu nanoparticles in dispersion was monitored through the analysis of the absorbance spectra at different stages during the process of synthesis. The stability of the Cu nanoparticles dispersed in aqueous medium was investigated after different time intervals. Cu colloid was found to be stable up to 18 hours without major aggregation under atmospheric condition. The size and size distribution of the particles were examined by particle size analyzer. The morphology of the particle synthesised was examined by SEM and AFM. After 24 hours of storage in open air there was some agglomeration of nanoparticles as observed by particle size analyzer and AFM studies. But found stable with the use of 1 % trisodium citrate as stabilizer.
The box H+ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase (1998)

Many or all of the sites of pseudouridine (Psi) formation in eukaryotic rRNA are selected by site-specific base-pairing with members of the box H + ACA class of small nucleolar RNAs (snoRNAs). Database searches previously identified strong homology between the rat nucleolar protein Nap57p, its yeast homolog Cbf5p, and the Escherichia coli Psi synthase truB/P35. We therefore tested whether Cbf5p is required for synthesis of Psi in the yeast rRNA. After genetic depletion of Cbf5p, formation of Psi in the pre-rRNA is dramatically inhibited, resulting in accumulation of the unmodified rRNA. Protein A-tagged Cbf5p coprecipitates all tested members of the box H + ACA snoRNAs but not box C + D snoRNAs or other RNA species. Genetic depletion of Cbf5p leads to depletion of all box H + ACA snoRNAs. These include snR30, which is required for pre-rRNA processing. Depletion of Cbf5p also results in a pre-rRNA processing defect similar to that seen on depletion of snR30. We conclude that Cbf5p is likely to be the rRNA Psi synthase and is an integral component of the box H + ACA class of snoRNPs, which function to target the enzyme to its site of action.
Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase (2008)

Nonribosomal peptide synthetases (NRPSs) are modular multidomain enzymes that act as an assembly line to catalyze the biosynthesis of complex natural products. The crystal structure of the 144-kilodalton Bacillus subtilis termination module SrfA-C was solved at 2.6 angstrom resolution. The adenylation and condensation domains of SrfA-C associate closely to form a catalytic platform, with their active sites on the same side of the platform. The peptidyl carrier protein domain is flexibly tethered to this platform and thus can move with its substrate-loaded 4'-phosphopantetheine arm between the active site of the adenylation domain and the donor side of the condensation domain. The SrfA-C crystal structure has implications for the rational redesign of NRPSs as a means of producing novel bioactive peptides.
On Myelinated Axon Plasticity and Neuronal Circuit Formation and Function (2017)

Studies of activity-driven nervous system plasticity have primarily focused on the gray matter. However, MRI-based imaging studies have shown that white matter, primarily composed of myelinated axons, can also be dynamically regulated by activity of the healthy brain. Myelination in the CNS is an ongoing process that starts around birth and continues throughout life. Myelin in the CNS is generated by oligodendrocytes and recent evidence has shown that many aspects of oligodendrocyte development and myelination can be modulated by extrinsic signals including neuronal activity. Because modulation of myelin can, in turn, affect several aspects of conduction, the concept has emerged that activity-regulated myelination represents an important form of nervous system plasticity. Here we review our increasing understanding of how neuronal activity regulates oligodendrocytes and myelinated axons <i>in vivo</i>, with a focus on the timing of relevant processes. We highlight the observations that neuronal activity can rapidly tune axonal diameter, promote re-entry of oligodendrocyte progenitor cells into the cell cycle, or drive their direct differentiation into oligodendrocytes. We suggest that activity-regulated myelin formation and remodeling that significantly change axonal conduction properties are most likely to occur over timescales of days to weeks. Finally, we propose that precise fine-tuning of conduction along already-myelinated axons may also be mediated by alterations to the axon itself. We conclude that future studies need to analyze activity-driven adaptations to both axons and their myelin sheaths to fully understand how myelinated axon plasticity contributes to neuronal circuit formation and function.
Two color temporally correlated infrared background measurements (1998)

The use of high speed multicolor imaging sensors provides a valuable tool for characterizing both the infrared signatures of missiles as well as clutter. Over 14 flight hours worth of collections were made of difficult to characterize clutter. This additional data can be utilized to develop and improve missile warning algorithms for better false alarm rates. These analyses show that although a two color staring system could have multiple advantages over a single color system in false alarm rejection, the clutter rejection capabilities can be limited by the relatively low inter-band correlations between the red and blue bands.
Synthesis of PMMA star polymers with siloxane cores via group-transfer polymerization using silyl ketene acetal functionalized cyclic siloxanes (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of PMMA star polymers with siloxane cores via group-transfer polymerization using silyl ketene acetal functionalized cyclic siloxanesZ. Zhu, J. Rider, C. Y. Yang, M. E. Gilmartin, and G. E. WnekCite this: Macromolecules 1992, 25, 26, 7330–7333Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/ma00052a040https://doi.org/10.1021/ma00052a040research-articleACS PublicationsRequest reuse permissionsArticle Views365Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts