gebhart/patrepeval huggingface dataset:
Bacterial flora of the parturient vagina--implications for neonatal sepsis. (1978)

A bacteriological study of vaginal swabs taken from 78 parturient women at Lagos University Teaching Hospital (L.U.T.H.) is presented. 26.83% of the vaginal cultures were sterile. The most frequently isolated bacteria were Staphylococcus spp. 21.4%, followed by beta hemolytic streptococci 16.65%, of which approximately a half belonged to Lancefield group B. Escherichia coli was isolated in 11.1% of the cases. The implications for neonatal and puerperal sepsis are discussed.
Contact angle stability: Reorganization of monolayer surfaces? (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTContact angle stability: Reorganization of monolayer surfaces?Stephen D. Evans, Ravi Sharma, and Abraham UlmanCite this: Langmuir 1991, 7, 1, 156–161Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/la00049a028https://doi.org/10.1021/la00049a028research-articleACS PublicationsRequest reuse permissionsArticle Views1395Altmetric-Citations142LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A simple light scattering method to assay magnetism in<i>Magnetospirillum gryphiswaldense</i> (1995)

A simple optical method was developed for assaying cellular magnetism in culture samples of magnetic spirilla. Cells are aligned parallel to the field lines in a magnetic field, resulting in a change in light scattering. The ratio of scattering intensities at different angles of magnetic field relative to the light beam (<it>C</it><inf>mag</inf>) is used to characterize the average magnetic orientation of the cells. <it>C</it><inf>mag</inf> was found to be well correlated with the average number of particles in different magnetic cell populations. Thus, estimations of magnetosome content can be made using magnetically induced differential light scattering. The method provides a fast and sensitive tool for monitoring the magnetite formation in growing cultures of <it>Magnetospirillum gryphiswaldense</it>.
An alternative construction of interleaved RLL codes for partial response channels using multichannel methods (1994)

Current work in magnetic recording channels has demonstrated significant improvement in recording density using partial response communication methods along with maximum likelihood detection. The class IV partial response channel (PR4) behaves as the interleaving of two identical run-length limited (RLL) channels. Efficient recording codes for the PR4 channel have been made by considering a channel bit sequence to be composed of two interleaved subsequences. Finite state techniques are used to describe run-length constraints on each subsequence as well as a global run-length constraint on both sequences combined. A recent paper by Swanson and Wolf discusses multichannel run-length limited codes that turn out to be very similar to interleaved run-length limited codes. The present paper discusses the similarities between the code description of multichannel RLL codes and the interleaved RLL codes required by the PR4 channel. The extension of the techniques of multichannel RLL work to the interleaved problem is discussed. It was found that suitable code constructions are possible by viewing the problem as two distinct RLL codes that have individual maximum run-lengths onto which a global run-length is imposed. Two examples are developed to illustrate the ideas.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Prevention of physostigmine-induced lethality in rats. A pharmacological analysis. (1982)

A systematic study of a large number of compounds from various pharmacological classes was performed to better define their interaction with the cholinergic nervous system. An 'in vivo' test procedure called 'physostigmine antagonism' in rats was used; it involved the administration of the test compounds, measurement of the pupil diameter and recording of the survival time after injection of a lethal dose of physostigmine. Known peripherally acting anticholinergics, such as isopropamide and methylscopolamine did not protect from physostigmine lethality at doses up to more than 150 times the mydriatic dose. Known centrally acting anticholinergics, such as dexetimide and benztropine, protected from lethality at doses equal to or slightly higher than the mydriatic dose. Penetration into the brain of a muscarinic blocking agent thus appeared to be a sufficient condition to significantly reduce the cholinergic overstimulation of the CNS that results from inhibition of acetylcholine hydrolysis. Drugs of other pharmacological classes that are known to have anticholinergic activity in addition to their more characteristic action, were also active in the physostigmine test. They include most of the tricyclic antidepressants, some antihistamines such as diphenhydramine and cyproheptadine, some ganglion blocking agents such as mecamylamine and the neuroleptic clozapine. Drugs with hypnotic or anticonvulsant properties, sedative neuroleptics and high doses of some members of other pharmacological classes protected from physostigmine-induced lethality by a mechanism not based on anticholinergic activity. The results further show that a number of pharmacological actions: dopamine, histamine H1 and serotonin S2 antagonism, MAO-inhibition, alpha-adrenergic blockade etc. are all insufficient to produce physostigmine antagonism.
Toward Prediction of Efficacy of Chemotherapy: A Proof of Concept Study in Lung Cancer Patients Using [11C]docetaxel and Positron Emission Tomography (2013)

Microdosing data of [(11)C]docetaxel PET can be used to predict tumor uptake of docetaxel during chemotherapy. The present study provides a framework for investigating the PET microdosing concept for radiolabeled anticancer drugs in patients.
An Online Visualization System for Streaming Log Data of Computing Clusters (2013)

Monitoring a computing cluster requires collecting and understanding log data generated at the core, computer, and cluster levels at run time. Visualizing the log data of a computing cluster is a challenging problem due to the complexity of the underlying dataset: it is streaming, hierarchical, heterogeneous, and multi-sourced. This paper presents an integrated visualization system that employs a two-stage streaming process mode. Prior to the visual display of the multi-sourced information, the data generated from the clusters is gathered, cleaned, and modeled within a data processor. The visualization supported by a visual computing processor consists of a set of multivariate and time variant visualization techniques, including time sequence chart, treemap, and parallel coordinates. Novel techniques to illustrate the time tendency and abnormal status are also introduced. We demonstrate the effectiveness and scalability of the proposed system framework on a commodity cloud-computing platform.
Improving the Performance of a Geophone Through Capacitive Position Sensing and Feedback (1998)

Abstract This paper reports on the improved performance of a geo-phone obtained by measuring the displacement of its proof mass capacitively rather than inductively and operating the sensor as a closed loop system. A measurement of the displacement of the proof mass rather than the velocity measurement made with a conventional geophone provides better low frequency performance. As a result, a geophone can be considered for use in a broader array of applications. A capacitive geophone can operate in either an open loop or closed loop mode. This paper describes a closed loop geophone system with a frequency response similar to the state of the art Streckeisen seismometers.
Dispersion matching of sample and reference arms in optical frequency domain reflectometry-optical coherence tomography using a dispersion-shifted fiber (2007)

We demonstrate dispersion matching of sample and reference arms in an optical frequency domain reflectometry-optical coherence tomography (OFDR-OCT) system with a discretely swept light source centered at 1550 nm, using a dispersion-shifted fiber (DSF) in the reference arm. By adjusting the optical length of the DSF so that it is equal to that of the free space in the sample arm, we achieve a high resolution of 27.2 microm (in air), which is very close to the theoretically expected value of 26.8 microm when we measure the reflective mirror. This improves the degraded resolution (36.1 microm ) in a system using a conventional single-mode fiber when the free-space length in the sample arm was 909 mm. We also demonstrate a clear interface between air and the enamel layer of an extracted human tooth with the discretely swept (DS) OFDR-OCT imaging due to the improved resolution provided by this technique. These results show the potential of our DS-OFDR-OCT system for a compact low-cost apparatus with a high axial resolution.
Folding kinetics of the lipoic acid‐bearing domain of human mitochondrial branched chain α‐ketoacid dehydrogenase complex (2002)

A reversible two-step (native state<-->denatured state) folding mechanism based on equilibrium and stopped flow experiments is proposed for urea denaturation of the lipoyl-bearing domain (hbLBD) of human mitochondrial branched chain alpha-ketoacid dehydrogenase (BCKD) complex. The results from this circular dichroism (CD) and fluorescence study have ruled out populated kinetic or equilibrium intermediates on folding pathway of this beta-barrel domain under experimental conditions. Both studies suggested mono-exponential kinetics without any burst phases. Moreover the thermodynamic parameters DeltaG(H(2)O) and m obtained from the kinetic analysis are consistent with the equilibrium measurements.
A Brief Review of Bone Adaptation to Unloading (2008)

Weight-bearing bone is constantly adapting its structure and function to mechanical environments. Loading through routine exercises stimulates bone formation and prevents bone loss, but unloading through bed rest and cast immobilization as well as exposure to weightlessness during spaceflight reduces its mass and strength. In order to elucidate the mechanism underlying unloading-driven bone adaptation, ground-based in vitro and in vivo analyses have been conducted using rotating cell culturing and hindlimb suspension. Focusing on gene expression studies in osteoblasts and hindlimb suspension studies, this minireview introduces our recent understanding on bone homeostasis under weightlessness in space. Most of the existing data indicate that unloading has the opposite effects to loading through common signaling pathways. However, a question remains as to whether any pathway unique to unloading (and not to loading) may exist.
Tracking and Connecting Topics via Incremental Hierarchical Dirichlet Processes (2011)

Much research has been devoted to topic detection from text, but one major challenge has not been addressed: revealing the rich relationships that exist among the detected topics. Finding such relationships is important since many applications are interested in how topics come into being, how they develop, grow, disintegrate, and finally disappear. In this paper, we present a novel method that reveals the connections between topics discovered from the text data. Specifically, our method focuses on how one topic splits into multiple topics, and how multiple topics merge into one topic. We adopt the hierarchical Dirichlet process (HDP) model, and propose an incremental Gibbs sampling algorithm to incrementally derive and refine the labels of clusters. We then characterize the splitting and merging patterns among clusters based on how labels change. We propose a global analysis process that focuses on cluster splitting and merging, and a finer granularity analysis process that helps users to better understand the content of the clusters and the evolution patterns. We also develop a visualization process to present the results.
Improved efficacy and tolerability of retinoic acid in acne vulgaris: a new topical formulation with cyclodextrin complex ψ (2004)

The topical RA/beta-CD complex, in hydrogel and moisturizing base, was more effective than the twice concentrated commercial RA product. There were few topical side-effects with this new formulation, which increases patient compliance. Topical RA/beta-CD (0.025% RA) did not significantly reduce sebum secretion but may help to preserve optimum epidermal moisture content with the proper base formulation. This is the first study in the literature reporting efficacy and tolerability of the topical RA/beta-CD complex in acne vulgaris. We conclude that the topical RA/beta-CD complex displays an improved efficacy and tolerability profile and is an effective treatment alternative for acne vulgaris.
A concurrent high-level language based real-time controller (1988)

Real-time control applications pose particular implementation problems caused by the required low latency to external events, the highly concurrent nature of the application software, and the reliability requirements usually associated with control. The implementation of concurrent real-time software is typically done at the machine language level, which is difficult, costly and non-portable. In this paper, a shared-memory multiprocessor realization of Modula-2 is proposed as a possible high-level language environment for real-time control applications. The implementation is well suited to support dynamic processor allocation and quick runtime response to external events.
Cancer-Derived Lysophosphatidic Acid Stimulates Differentiation of Human Mesenchymal Stem Cells to Myofibroblast-Like Cells (2007)

Lysophosphatidic acid (LPA) is enriched in ascites of ovarian cancer patients and is involved in growth and invasion of ovarian cancer cells. Accumulating evidence suggests cancer-associated myofibroblasts play a pivotal role in tumorigenesis through secreting stromal cell-derived factor-1 (SDF-1). In the present study, we demonstrate that LPA induces expression of alpha-smooth muscle actin (alpha-SMA), a marker for myofibroblasts, in human adipose tissue-derived mesenchymal stem cells (hADSCs). The LPA-induced expression of alpha-SMA was completely abrogated by pretreatment of the cells with Ki16425, an antagonist of LPA receptors, or by silencing LPA(1) or LPA(2) isoform expression with small interference RNA (siRNA). LPA elicited phosphorylation of Smad2/3, and siRNA-mediated depletion of endogenous Smad2/3 or adenoviral expression of Smad7, an inhibitory Smad, abrogated the LPA induced expression of alpha-SMA and phosphorylation of Smad2/3. LPA-induced secretion of transforming growth factor (TGF)-beta1 in hADSCs, and pretreatment of the cells with SB431542, a TGF-beta type I receptor kinase inhibitor, or anti-TGF-beta1 neutralizing antibody inhibited the LPA-induced expression of alpha-SMA and phosphorylation of Smad2. Furthermore, ascites from ovarian cancer patients or conditioned medium from ovarian cancer cells induced expression of alpha-SMA and phosphorylation of Smad2, and pretreatment of the cells with Ki16425 or SB431542 abrogated the expression of alpha-SMA and phosphorylation of Smad2. In addition, LPA increased the expression of SDF-1 in hADSCs, and pretreatment of the cells with Ki16425 or SB431562 attenuated the LPA-stimulated expression of SDF-1. These results suggest that cancer-derived LPA stimulates differentiation of hADSCs to myofibroblast-like cells and increases SDF-1 expression through activating autocrine TGF-beta1-Smad signaling pathway.
Problems in pathologic staging of lung cancer. (2006)

The variety of practical problems that can arise during the assessment of important prognostic and predictive features such as resection margin status and evaluation of lymphovascular invasion are reviewed. A brief discussion of the assessment of the effects of neoadjuvant therapy on resected lung neoplasms is also included.
Application of CPL with Interference Mapping Lithography to generate random contact reticle designs for the 65-nm node (2004)

Imaging contact and via layers continues to be one of the major challenges to be overcome for 65nm node lithography. Initial results of using ASML MaskTools' CPL Technology to print contact arrays through pitch have demonstrated the potential to further extend contact imaging to a k1 near 0.30. While there are advantages and disadvantages for any potential RET, the benefits of not having to solve the phase assignment problem (which can lead to unresolvable phase conflicts), of it being a single reticle - single exposure technique, and its application to multiple layers within a device (clear field and dark field) make CPL an attractive, cost effective solution to low k1 imaging. However, real semiconductor circuit designs consist of much more than regular arrays of contact holes and a method to define the CPL reticle design for a full chip circuit pattern is required in order for this technique to be feasible in volume manufacturing. Interference Mapping Lithography (IML) is a novel approach for defining optimum reticle patterns based on the imaging conditions that will be used when the wafer is exposed. Figure 1 shows an interference map for an isolated contact simulated using ASML /1150 settings of 0.75NA and 0.92/0.72/30deg Quasar illumination. This technique provides a model-based approach for placing all types features (scattering bars, anti-scattering bars, non-printing assist features, phase shifted and non-phase shifted) for the purpose of enhancing the resolution of the target pattern and it can be applied to any reticle type including binary (COG), attenuated phase shifting mask (attPSM), alternating aperture phase shifting mask (altPSM), and CPL. In this work, we investigate the application of IML to generate CPL reticle designs for random contact patterns that are typical for 65nm node logic devices. We examine the critical issues related to using CPL with Interference Mapping Lithography including controlling side lobe printing, contact patterns with odd symmetry, forbidden pitch regions, and reticle manufacturing constraints. Multiple methods for deriving the interference map used to define reticle patterns for various RET's will be discussed. CPL reticle designs that were created from implementing automated algorithms for contact pattern decomposition using MaskWeaver will also be presented.
Cloning, Sequencing, and Expression of the Pyruvate Carboxylase Gene in <i>Lactococcus lactis</i> subsp. <i>lactis</i> C2 (2000)

A functional pyc gene was isolated from Lactococcus lactis subsp. lactis C2 and was found to complement a Pyc defect in L. lactis KB4. The deduced lactococcal Pyc protein was highly homologous to Pyc sequences of other bacteria. The pyc gene was also detected in Lactococcus lactis subsp. cremoris and L. lactis subsp. lactis bv. diacetylactis strains.
An interactive concatenated turbo coding system (2002)

Although turbo codes with iterative decoding have been shown to achieve bit-error rates (BER) close to the Shannon limit, they suffer from three disadvantages: a large decoding delay, an error floor at low BER, and a relatively poor frame error performance (FER). This paper presents an interactive concatenated turbo coding system in which a Reed-Solomon outer code is concatenated with a binary turbo inner code. In the proposed system, the outer code decoder and the inner turbo code decoder interact to achieve both good bit error and frame error performances. Also presented is an effective criterion for stopping the iterative decoding process and a new reliability-based decoding algorithm called the Chase-GMD algorithm for nonbinary codes.
A novel adaptive CMOS low-dropout regulator with 3A sink/source capability (2015)

A novel adaptive CMOS low-dropout regulator (LDO) is proposed for DDR4 memory power supply. By using a two stage structure, this LDO can adjust its transfer path to afford a very large range of load current from 0 A to 3 A. Two NMOS pass elements are used to do both sourcing and sinking functions, which are not included in traditional LDOs. The improved structure with two NMOS transistors performs a good stability by using Miller compensation method. Fast load transition is also obtained due to 20 μF ceramic capacitor at output terminal. The circuit has been demonstrated in TSMC 0.18μm standard CMOS process with a 1.2 V input voltage under 3.3 V supply voltage. The simulation results show that the LDO consumes a quiescent current of 70 μA, the phase margin is at least 47 degree with 1 mA to 3 A load current. The transient output voltage is constrained within 40 mV when load current ramps from 0 A to 3 A with 20 μF capacitor load.
Design and research of asymmetric micro-channel cooling system in MEMS-based Microstrip antenna (2010)

The microstrip antenna manufactured by MEMS has a few good features, such as small size and light weight. However, the substrate and feeder often have lager energy consumption and the antenna thermal area is small. When the antenna reaching normal power demand worked for 15 seconds, the peak temperation will reach 105°C and could not continue to work properly. This paper simulated the antenna structure and its power consumption to look for the peak temperature region, and designed asymmetric micro-channel cooling structure which is based on the Microstrip antenna array and the experimental data. Simulation indicated that peak temperature decreased by 9% by asymmetric structure cooling system driven by 1.2*10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> W micro-pump power. And antenna can guarantee work normally under 61.6°C.
Relating Transportation Quality Indicators to Economic Conditions in the South-Central U.S. (2011)

Investment in transportation infrastructure is widely assumed to spur economic growth, a belief that persists among both the general public and government officials. However, research has provided inconsistent evidence to date, and many researchers believe that good transportation is a necessary but insufficient condition for regional growth. This study examines the issue from a different perspective than the majority of past research, using spatial regression techniques to explore the relationship between transportation quality and regional economic development at an intermediate spatial resolution. Using federal highway statistics on pavement roughness and bridge quality, this research examines the relationship between measurable results of transportation spending, as evidenced by better quality roads and bridges, and various indicators of economic health. This relationship is examined in the South-Central U.S. (Arkansas, Kansas, Oklahoma, and Texas) at the county level and uncovers moderate to weak regression coefficients overall but with notable spatial variations across the study area.
Randomized Controlled Phase Ib Study of Ghrelin Agonist, RM-131, in Type 2 Diabetic Women With Delayed Gastric Emptying (2012)

RM-131 greatly accelerates the GE of solids in patients with type 2 diabetes and documented DGE. PK is similar in diabetic patients and HVs.