gebhart/patrepeval huggingface dataset:
Molecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant mice. (1987)

Molecular analysis of the heterodimeric T-cell antigen receptor of insulin-specific class II-restricted T-cell hybridomas (THys) derived from C57BL/6 (B6) wild-type and B6.C-H-2bm12 (bm12) mutant mice revealed that such T cells use a diverse V gene repertoire. Analysis of three THys that use related V genes, however, showed a number of novel features. Two THys that share major histocompatibility complex restriction use V alpha genes that are 98.6% homologous. Two THys sharing the same antigen fine specificity use a particular germ line V beta D beta J beta combination. A 21-base-pair deletion in the 5' segment of the J beta gene occurs in one THy, suggesting a novel mechanism for generating diversity in T-cell antigen receptor beta genes. The first amino acid encoded by N sequences at the V-D junction is conserved in a pair of T cells which recognize identical antigenic epitopes. The implications of these findings for the structural mechanisms underlying major histocompatibility complex-restricted antigen-specific T-cell recognition are discussed.
Real-Time Event Identification Using Deep Graph Learning and PMU Data (2020)

Phasor measurement units (PMUs) are being widely installed on power transmission systems, which provides a unique opportunity to enhance wide-area situational awareness. One key application is to utilize PMU data for real-time event identification. However, taking full advantage of all PMU data is still an open problem. This paper proposes a novel event identification method using multiple PMU measurements and deep graph learning techniques. Unlike previous models that rely on single PMU and ignore the interactive relationships between different PMUs or use multiple PMUs but determine the functional connectivity manually, our method performs data-driven interactive graph inference. Meanwhile, to ensure the optimality of the graph learning procedure, our method learns the interactive graph jointly with the event identification model. Moreover, instead of generating a single statistical graph to represent pair-wise relationships among PMUs during different events, our approach produces different event identification-specific graphs for different power system events, which handles the uncertainty of event location. To test the proposed data-driven approach, a large real dataset from tens of PMU sources and the corresponding event logs have been utilized in this work. The numerical results validate that our method has higher identification accuracy compared to the previous methods.
Auditoria/Informática: uma conjunção e novos rumos (1976)

Com a utilizacao de teleprocessamento, novos equipamentos perifericos, como terminais, o metodo de auditoria ao redor - around - tournou-se obsoleto dando lugar a auditoria atraves - through -. Neste trabalho decreve-se com detalhes a tecnica do test deck, das mais modernas para auditoria de sistemas de informacao que usam computadores eletronicos. Outras tecnicas, no entanto, estao sendo pesquisadas, o que certamente trara um continuo aperfecoamento ao trabalho de auditoria.
Holo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription (2013)

Transcription factor (TF)IID is a central player in activated transcription initiation. Recent evidence suggests that the role and composition of TFIID are more diverse than previously understood. To investigate the effects of changing the composition of TFIID in a simple system, we depleted TATA box-binding protein-associated factor (TAF)1 from Drosophila cells and determined the consequences on metal-induced transcription at an inducible gene, metallothionein B. We observe a marked increase in the levels of both the mature message and pre-mRNA in TAF1-depleted cells. Under conditions of continued metal exposure, we show that TAF1 depletion increases the magnitude of the initial transcription burst but has no effect on the timing of that burst. We also show that TAF1 depletion causes delay in the shutoff of transcription upon removal of the stimulus. Thus, TAFs are involved in both establishing an upper limit of transcription during induction and efficiently turning the gene off once the inducer is removed. Using genome-wide nascent sequencing, we identify hundreds of genes that are controlled in a similar manner, indicating that the findings at this inducible gene are likely generalizable to a large set of promoters. There is a long-standing appreciation for the importance of the spatial and temporal control of transcription. Here we uncover an important third dimension of control: the magnitude of the response. Our results show that the magnitude of the transcriptional response to the same signaling event, even at the same promoter, can vary greatly depending on the composition of the TFIID complex in the cell.
High dielectric constant thin film EBG power/ground network for broad-band suppression of SSN and radiated emissions (2005)

We experimentally demonstrated the great advantages of a high dielectric constant thin film electromagnetic bandgap (EBG) power distribution network (PDN) for the suppression of power/ground noises and radiated emissions in high-performance multilayer digital printed circuit boards (PCBs). Five-layer test PCBs were fabricated and their scattering parameters measured. The power plane noise and radiated emissions were measured, investigated and related to the PDN impedance. This successfully demonstrated that the bandgap of the EBG was extended more than three times, covering a range of hundreds of MHz using a 1-cm /spl times/ 1-cm EBG cell, the SSN was reduced from 170 mV to 10 mV and the radiated emission was suppressed by 22 dB because of the high dielectric constant thin film EBG power/ground network.
Radio-Contrast Enhancement of Urinary Tract Stones (1991)

Most urologists treating stone disease with any method (ESWL, PCL, URS) have encountered problems of poor stone visualization with fluoroscopy. This difficulty to localize urinary tract (UT) stones or fragments may result in incomplete stone extraction, prolonged surgery and increased risk of recurrence and post-operative complications. We have sought and found means to increase the radioopacity of mineral UT stones by a simple pre-operative perfusion technique. The capacity of radioopacification has first been demonstrated in in vitro incubations of fragments of human mineral stones with aqueous solutions of barium, of the lanthanides and of the two natural actinides. Most of the incubations led to considerable radio-contrast enhancement and heavy metal incorporation, measured by X-ray fluorescence analysis. Dogs with implanted human stone fragments were used as an in vivo model. The UT were perfused through a retrograde pyelic catheter with heavy metal salts solutions, the ensuing radioopacification of the implanted UT-stones was estimated by abdominal radiographies and the metal incorporation was measured on the retrieved stones. Considerable radioopacity enhancement together with heavy metal incorporation was observed for the following elements: Sr, Ba and the lanthanides Gd and Yb. The pathological evaluation of the urothelial linings from animals treated with lanthanide salt showed no toxic effects.
EL LEGADO FERNÁNDEZ DE AVILÉS Y ALVAREZ-OSSORIO EN LA UNIVERSIDAD AUTÓNOMA DE MADRID (2004)

El presente trabajo constituye un avance de los trabajos que se están desarrollando en la Universidad Autónoma de Madrid en torno al estudio del Legado documental de Augusto Fernández de Avilés y Álvarez-Ossorio, donado en 1998 por su familia a esta institución universitaria. Debidamente informatizado en 14 bases de datos, generadas específicamente para este archivo, sus cerca de 10.000 registros constituyen hoy clara evidencia de la intensa actividad científica llevada a cabo por el citado arqueólogo en sus casi 40 años de actividad profesional. Sendos corpora sobre escultura ibérica y romana, Diarios de Excavaciones, algunos de ellos todavía inéditos, de las numerosas excavaciones que llegó a realizar, un archivo fotográfico personal con más de 900 imágenes entre negativos y positivos, o la correspondencia mantenida con numerosos investigadores, tanto nacionales como extranjeros, constituyen una apretada muestra de lo que guarda este Legado. El estudio del mismo está previsto que culmine en un libro a publicar en la Serie Varia que se edita en esta misma Universidad Autónoma y pretende constituir, tal y como constará en su título, un merecido homenaje a su persona y a su obra.Palabras clave: Fernández de Avilés, Biografía, Legado, bases de datos, fotografía, diarios de excavaciones, Cerro de los SantosRésuméDans ce travail on présente l´état du projet de recherche qu´on devéloppe actuellement à l´Université Autónoma de Madrid sur l´archive documentaire de l´archéologue Augusto Fernández de Avilés y Álvarez-Ossorio, dont la famille a fait don en 1998 à cette Université. L´archive a été digitalisé et catalogué grâce à 14 bases de données, crées spécifiquement pour ce projet-là. Les plus de 10.000 enregistrements prouvent aujourd´hui la très importante activité scientifique dont cet archéologue a été responsable dans les plus de 40 ans d´activité scientifique. On y retrouve, par exemple, deux corpora sur la sculpture ibérique et romaine, quelques Journaux de Fouilles des nombreux fouilles qu´il a dirigé et qui restent parfois inédits, un archive photographique personnel de plus de 900 images entre les négatives et les positives, ou sa correspondance avec des nombreux chercheurs espagnols et étrangers. Tout ce genre de renseignements montre aujourd´hui la richesse de cette donation documentaire. L´étude que l´Université Autonoma a entrepris finira avec un livre que sera édité dans la série Varia du Département de Préhistoire et Archéologie, et dont le but est de bien saisir la figure scientifique et personnel du chercheur ainsi que lui donner un juste hommage.Mots clés. Fernández de Avilés, Biographie, Donation documentaire, base de données, photographie, journal de fouilles, Cerro de los Santos.
[Transuterine tubal sterilization by hysteroscopy (author's transl)]. (1973)

A new method of female sterilization is described, a transuterine electrocoagulation of the pars intramuralis tubae by hysteroscopy. 115 patients were operated on under general or local anesthesia. Follow-up examinations showed that bilateral tubal occlusion was obtained when the procedure was done in the early proliferative phase with a coagulation temperature of 80 degrees C.
A Study of Computer-Assisted Tomography (1984)

One hundred twenty-two patients with surgically confirmed pathology consisting of either herniated lumbar disc, spinal stenosis, or both were included in this investigation. For each of these patients, preoperative metrizamide myelography and computerized tomography were performed. Each myelogram and CT scan was read blindly so that the neuroradiologist interpreting the study had no knowledge of the patient's surgical pathology, clinical examination, nor any knowledge of the interpretation of the other preoperative test. A painstaking attempt was made to describe precisely both the exact nature of the preoperative myelogram and CT scan interpretations. The correlations between the preoperative interpretation of each test and the observed surgical findings then were analyzed statistically. Based upon this analysis, myelography was found to be more accurate than computed tomography in the diagnosis of herniated lumbar disc (83% vs. 72%). In the diagnosis of spinal stenosis, myelography was slightly more accurate than computed tomography (93% vs. 89%). Based upon the results of this study, the authors conclude that metrizamide myelography is more accurate than computed tomography in the diagnosis of both herniated lumbar disc and spinal stenosis and remains the diagnostic study of choice for these conditions. Furthermore, metrizamide myelography gives the added advantage of visualizing the thoracolumbar junction and, thus, affords the opportunity to diagnose occult spinal tumors.
In Vitro Activity of a Novel Antimycobacterial Compound, <i>N</i> -Octanesulfonylacetamide, and Its Effects on Lipid and Mycolic Acid Synthesis (2001)

beta-Sulfonyl carboxamides have been proposed to serve as transition-state analogues of the beta-ketoacyl synthase reaction involved in fatty acid elongation. We tested the efficacy of N-octanesulfonylacetamide (OSA) as an inhibitor of fatty acid and mycolic acid biosynthesis in mycobacteria. Using the BACTEC radiometric growth system, we observed that OSA inhibits the growth of several species of slow-growing mycobacteria, including Mycobacterium tuberculosis (H37Rv and clinical isolates), the Mycobacterium avium complex (MAC), Mycobacterium bovis BCG, Mycobacterium kansasii, and others. Nearly all species and strains tested, including isoniazid and multidrug resistant isolates of M. tuberculosis, were susceptible to OSA, with MICs ranging from 6.25 to 12.5 microg/ml. Only three clinical isolates of M. tuberculosis (CSU93, OT2724, and 401296), MAC, and Mycobacterium paratuberculosis required an OSA MIC higher than 25.0 microg/ml. Rapid-growing mycobacterial species, such as Mycobacterium smegmatis, Mycobacterium fortuitum, and others, were not susceptible at concentrations of up to 100 microg/ml. A 2-dimensional thin-layer chromatography system showed that OSA treatment resulted in a significant decrease in all species of mycolic acids present in BCG. In contrast, mycolic acids in M. smegmatis were relatively unaffected following exposure to OSA. Other lipids, including polar and nonpolar extractable classes, were unchanged following exposure to OSA in both BCG and M. smegmatis. Transmission electron microscopy of OSA-treated BCG cells revealed a disruption in cell wall synthesis and incomplete septum formation. Our results indicate that OSA inhibits the growth of several species of mycobacteria, including both isoniazid-resistant and multidrug resistant strains of M. tuberculosis. This inhibition may be the result of OSA-mediated effects on mycolic acid synthesis in slow-growing mycobacteria or inhibition via an undescribed mechanism. Our results indicate that OSA may serve as a promising lead compound for future antituberculous drug development.
Shrinking wide compressors [BIST] (1995)

Quite often built-in self-test (BIST) designs make use of multiple-input signature registers (MISR's) to compress the test data. Normally a MISR includes a stage for every signal that it is sampling. In some applications this leads to very wide MISR's that may include several hundred stages. Wide MISR's pose problems in terms of hardware and wiring overhead. Shorter compressors are, therefore, needed. This paper investigates the problem of shrinking an MISR so that it samples multiple signals at every stage. The ultimate shrinkage occurs when only the parity of the sampled signals is compressed. This is the case when a MISR is replaced by a single-input signature register (SISR). Issues like detection probability loss, test length penalty, and fault coverage degradation are some of the disadvantages that may arise from the MISR shrinkage. Minimizing the effect of these issues is a precondition to the success of this method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mutation and virulence assessment of chromosomal genes of Rhodococcus equi 103. (2007)

Rhodococcus equi can cause severe or fatal pneumonia in foals as well as in immunocompromised animals and humans. Its ability to persist in macrophages is fundamental to how it causes disease, but the basis of this is poorly understood. To examine further the general application of a recently developed system of targeted gene mutation and to assess the importance of different genes in resistance to innate immune defenses, we disrupted the genes encoding high-temperature requirement A (htrA), nitrate reductase (narG), peptidase D (pepD), phosphoribosylaminoimidazole-succinocarboxamide synthase (purC), and superoxide dismutase (sodC) in strain 103 of R. equi using a double-crossover homologous recombination approach. Virulence testing by clearance after intravenous injection in mice showed that the htrA and narG mutants were fully attenuated, the purC and sodC mutants were unchanged, and the pepD mutant was slightly attenuated. Complementation with the pREM shuttle plasmid restored the virulence of the htrA and pepD mutants but not that of the narG mutant. A single-crossover mutation approach was simpler and faster than the double-crossover homologous recombination technique and was used to obtain mutations in 6 other genes potentially involved in virulence (clpB, fadD8, fbpB, glnA1, regX3, and sigF). These mutants were not attenuated in the mouse clearance assay. We were not able to obtain mutants for genesfurA, galE, and sigE using the single-crossover mutation approach. In summary, the targeted-mutation system had general applicability but was not always completely successful, perhaps because some genes are essential under the growth conditions used or because the success of mutation depends on the target genes.
Caspase Inhibitor Therapy Synergizes With Costimulation Blockade to Promote Indefinite Islet Allograft Survival (2010)

This study suggests that addition of caspase inhibitor therapy to costimulation blockade will improve clinical transplantation by minimizing immune stimulation and thus reduce the requirement for long-term immunosuppressive therapy. The approach also prevents allosensitization, which may be an important component of chronic graft loss in clinical transplantation.
Separation of Functions and the National Labor Relations Board (1940)

rT HE administrative process has experienced rough going recently. Various quasi-erudite and legalistic groups have felt impelled to inquire into the mysterious workings of this relatively novel development in American government. Some attempts have been merely fishing expeditions,' others serious efforts to remedy what have been felt to be alarming defects in the system of government by men.2 One principal feature of the administrative process has drawn general fire, namely, the combination of administrative, prosecutory and judicial functions under one roof in the federal independent tribunals.3 This is attacked as in violation of Coke's time-worn dictum that no man should be judge in his own cause. The latter concept still possesses sufficient vitality to evoke consternation from those who fear for the independence of our democratic institutions and the rights of man. Such fears remain de-
Steric aspects of adrenegic drugs. XV. Use of isomeric activity ratio as a criterion to differentiate adrenergic receptors. (1971)

A new criterion is introduced to differentiate adrenergic receptors. It is postulated that if alpha adrenergic receptors in various tissues are of a single type, under proper experimental conditions, the isomeric activity ratio should be the same in these tissues. Conversely, if beta adrenergic receptors in various tissues are dissimilar, the isomeric activity ratios should be different. Thus, similarity of isomeric activity ratios of an agonist from different tissues is taken as evidence for the similarity of the receptor sites involved. Optical isomers of norepinephrine were selected for the purpose. Under normal circumstances the activity difference between the isomers is obscured by several factors. Although in some tissues catechol-O-methyltrans- ferase may be important, the density of adrenergic innervation appears to be the most important factor. In the normal tissue, the higher the density of adrenergic innervation, the lesser will appear the difference between the activity of (—)-and (+)-norepinephrine. When uptake was blocked by cocaine (in the presence of a catechol-O-methyltransferase inhibitor and a beta receptor blocking agent) the activity difference between (-)— (+)-norepinephrine was the same (approximately 300-fold) from six different tissues examined. Thus, it appears that alpha adrenergic receptors of rabbit aorta, vena cava, ileum and spleen, rat vas deferens and seminal vesicle are of a single type. In the normal tissue or tissue pretreated with cocaine, tropolone and phentolamine, the isomeric activity ratios from rat, rabbit and guinea-pig atria, guinea-pig trachea, rabbit aorta and bovine iris sphincter were not the same. Results are discussed in light of similarities and dissimilarities of adrenergic receptors of various organs.
Extending the digital core-based test methodology to support mixed-signal (2005)

This work presents an extension to a digital core-based test architecture to support testing of mixed-signal cores in a system-on-chip. It also presents a new mixed-signal test development flow that comprises a test library based approach to ease mixed-signal test development. The new flow was realized and experiments show clear advantages.
대학생의 자원봉사활동 참여동기 및 중단원인에 대한 분석 (2000)

The purpose of this study was to examine motives for participating, satisfaction for participating, reasons for discontinuing, and devices for activation in college students volunteering activity. Participants were 505 college students from a university and three colleges at the Cheju Island in Korea. Data were obtained from a structured questionnaire. The major findings were as follows. First, continuing participants placed significantly more importance on personal development and professional knowledge·technique motivation factors than did discontinuing participants. Second, continuing participants also rated that their voluntary activity participation allowed them to attain personal development/psychological benefits, professional technique leaming, and social recognition, expectation-satisfaction factors to a significant degree than did discontinuing participants. Third, continuing participants perceived significantly less maladjustment, dissatisfaction for reward system, expectancy-outcome disagreement, conflict/disharmony, motivation deprivation, lack of time constraints factors than did discontinuing participants. Forth, as devices to activate voluntary activity, continuing participants placed more importance on voluntary activity related program development/establishment of institutlonalized assistant system, improvement of consciousness, and introduction to reward system factors than did discontinuing participants.
Isolation and Identification of Chicken Infectious Anemia Virus in China (1997)

A chicken infectious anemia virus (CIAV) isolate was obtained from broiler flocks aged 25-40 days with anemia and poor performance and was designated SR43. The CIAV isolate was resistant to treatment with chloroform and induced thymus atrophy, bone marrow aplasia, and low hematocrit values when inoculated into 1-day-old, susceptible, specific-pathogen-free chicks. CIAV-specific antigens could be demonstrated in SR43-infected MDCC-MSB-1 cells, a cell line derived from a Marek's disease lymphoma, with the use of a monoclonal antibody specific for CIAV. CIAV DNA in infected MDCC-MSB-1 cell cultures was detected by using a polymerase chain reaction assay. These findings demonstrate that CIAV is present in China.
Laser-diode-pumped highly-efficient gain-shifted thulium-doped fiber amplifier operating in the 1480-1510-nm band (2001)

We have developed a gain-shifted thulium-doped fiber amplifier with high-optical-efficiency (29%) and high-output-power (+21.5 dBm) operating in the 1480-1510-nm wavelength band by employing a novel laser-diode pumping scheme of 1.4 and 1.56 microns.