gebhart/patrepeval huggingface dataset:
[Expression of p53 protein in colorectal cancer and its relationship to cell proliferative activity and prognosis]. (1996)

The expression of p53 protein in 66 cases of colorectal cancer and its relationship to cell proliferative activity, lymph node metastasis as well as prognosis were investigated by means of AB-PAP immunohistochemical technique. The results showed that 62.1% of colorectal cancer was positive. The cell proliferative activity and the frequency of lymph node metastasis in p53-positive cases were significantly higher than those of p53-negative cases (P < 0.05). The survival rate in patients with p53-positive tumors was significantly shorter than those with p53-negative tumors (P < 0.05). Our results suggest that the abnormal expression of p53 and cell proliferation associated with mutations are involved in both human carcinogenesis and lymph node metastasis of colorectal cancer. Examination of p53 expression is of value in understanding the degree of malignancy, and evaluating prognosis of the disease.
EFFECTS OF PROPYLENE GLYCOL OR GLYCEROL SUPPLEMENTATION OF THE DIET OF DAIRY COWS ON FEED INTAKE, MILK YIELD AND COMPOSITION, AND INCIDENCE OF KETOSIS (1973)

In two experiments designed to test the antiketogenic properties of propylene glycol and glycerol, concentrate mixtures containing 3, 6, or 9% propylene glycol or 3 or 6% glycerol were fed for the first 8 wk of lactation to a total of 120 cows. In the first experiment there were no significant effects (P > 0.05) of supplementation on milk yield and composition, feed intake, or energy balance. The cows fed a concentrate mixture containing 6% glycerol appeared to lose less body weight than the control cows or those fed concentrate containing either 3% glycerol or 3% propylene glycol. Cows fed the unsupplemented concentrate mixture were apparently less efficient in utilizing metabolizable energy than cows receiving either of the three supplemented rations but these differences were not significant (P > 0.05). There were no incidences of clinical ketosis and only 14 occurrences of positive ketone reactions in the milk (five on control, three on the 3% propylene glycol, four on 3% glycerol, and two on 6% glycerol). In the second experiment cows were subjected to slightly greater nutritional stress, which resulted in elevated ketone levels in 31 samples of milk from control cows, six from cows fed 3% propylene glycol, two for cows fed 6% propylene glycol, and three for cows fed 9% propylene glycol. Four cows, all on the control ration, developed clinical ketosis requiring glucose therapy. There were no consistent effects of propylene glycol on feed intake, body weight change, or efficiency of ration utilization. Propylene glycol supplementation appeared to increase milk yield at the 3 and 6% level and caused a slight decrease in milk fat and an increase in milk lactose percent.
Enhanced immunogenicity of the cultured rat fibrosarcoma KMT-17 by cultivation in a low concentration of fetal calf serum. (1987)

We examined in different culture conditions alterations in the tumorigenicity and immunogenicity of an A3 clone that had been derived from a rat fibrosarcoma KMT-17. When a fetal calf serum concentration in a culture medium was lowered from 10 to 1%, the tumorigenicity was diminished while the immunogenicity was enhanced in a reversible manner; this was accompanied by a reversible prolongation of the in vitro doubling time. These phenomena were not due to an increase in the quantities of the original tumor-associated antigen and/or of the rat major histocompatibility complex (RT1) but seemed to be due to the appearance of a unique antigen(s) that was detected by an antibody taken from rats immunized with A3 tumor cells cultured in the low fetal calf serum concentration; this antigen(s) may consist of glycoprotein and exist as a crypt antigen(s). These phenomena were measured by an absorption test and flow cytometric analysis. Our observations suggest that the in vitro culture condition of tumor cells, in particular their culturing in the low fetal calf serum concentration medium, modifies the surface of tumor cells and causes a diminishment in their tumorigenicity and an enhancement of their immunogenicity.
Incremental cost consensus algorithm in a smart grid environment (2011)

In a next generation power system, effective distributed control algorithms could be embedded in distributed controllers to properly allocate electrical power among connected buses autonomously. In this paper, we present a novel approach to solve the economic dispatch problem. By selecting the incremental cost of each generation unit as the consensus variable, the algorithm is able to solve the conventional centralized control problem in a distributed manner. The row-stochastic matrices have been used to indicate the different topologies of distribution systems and their configuration properties, such as convergence speeds. The simulation results of several case studies are provided to verify the algorithm.
Composite fiber adsorbent for rapid uptake of uranyl from seawater (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComposite fiber adsorbent for rapid uptake of uranyl from seawaterYoshiaki Kobuke, Iwao Tabushi, Takao Aoki, Tadami Kamaishi, and Ikuo HagiwaraCite this: Ind. Eng. Chem. Res. 1988, 27, 8, 1461–1466Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/ie00080a018https://doi.org/10.1021/ie00080a018research-articleACS PublicationsRequest reuse permissionsArticle Views216Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Laminar Flow in Capillary Electrophoresis:  Model and Experimental Results on Controlling Analysis Time and Resolution with Inductively Coupled Plasma Mass Spectrometry Detection (1996)

A capillary electrophoresis model was modified to include the effect of laminar flow. Experimental results using inorganic ions with a wide range of mobilities were compared to model predictions. The effect of laminar flow rate on analysis time, peak widths, peak asymmetry, and electrophoretic resolution is discussed. The laminar flow rate in the electrophoresis capillary was controlled by regulating the sheath flow rate in a concentric nebulizer interface. Laminar flow in the direction of the detector allows the analysis of positive, neutral, and negative species, all in one electrophoretic run, in less than 2 min. By increasing the sheath electrolyte flow rate, laminar flow in the electrophoresis capillary can be eliminated, resulting in increased resolution at the expense of an increase in analysis time. At higher sheath flow rates, laminar flow is generated in the electrophoresis capillary in the direction away from the detector to further retard the migration of charged species. When concentration overload contributes significantly to band broadening, resolution may be enhanced by inducing a laminar flow away from the detector.
FLUENCY AS A PERVASIVE ELEMENT IN THE MEASUREMENT OF CREATIVITY<sup>1</sup> (1970)

It was suggested that fluency, defined as number of responses, may misleadingly influence both high Intercorrelations sometimes reported among measures of creativity and low correlations sometimes reported between measures of creativity and intelligence. Subjects were 93 Saturday art school students between the ages of 9 and 15 years. Intercorrelations among five “creativity” scores derived from a slightly modified version of Torrance's Figure Completion Test and between these scores and Henmon‐Nelson Intelligence were compared using both raw creativity scores and creativity scores corrected for the effect of fluency. Uncorrected creativity scores intercorrelated high among themselves (mean r = .45) and low with intelligence (mean r = .09), while corrected creativity scores showed low intercorrelations among themselves (mean r = .08) and with intelligence (mean r = .13). These findings are interpreted as confirming the influence of fluency upon high intercorrelations among so‐called measures of creativity and as failing to support the suggestion that fluency may also influence low correlations among creativity and intelligence measures.
Increased Quality through Static Wheel Alignment and Automatic Toe Setting (1985)

<div class="section abstract"><div class="htmlview paragraph">The quality of wheel alignment depends on four factors: <ol class="list nostyle"> <li class="list-item"><span class="li-label">1.</span> <div class="htmlview paragraph">alignment equipment</div></li> <li class="list-item"><span class="li-label">2.</span> <div class="htmlview paragraph">toe setting operation</div></li> <li class="list-item"><span class="li-label">3.</span> <div class="htmlview paragraph">influence of the tire</div></li> <li class="list-item"><span class="li-label">4.</span> <div class="htmlview paragraph">hysteresis of the vehicle's suspension</div></li> </ol> </div><div class="htmlview paragraph">A static alignment machine, equipped with a computer, can handle all necessary vehicle data to determine exactly the toe adjustment values. The automatic toe-set equipment provides better results than a manual operation, as it uses much less of the given tolerance. A compensation of the hysteresis of the car is feasible by checking the suspension height.</div></div>
Ultrastructure of developing Isospora suis in cultured cells (1991)

The ultrastructure of Isospora suis sporozoites, type-1 meronts, and type-1 merozoites was examined, using transmission electron microscopy of infected cultured cells. The ultrastructure of sporozoites and type-1 merozoites was similar. Each possessed trimembranous pellicles, subpellicular microtubules, a conoid, anterior and posterior polar rings, rhoptries, micronemes, a single vesicular nucleus, tubular mitochondria, Golgi complexes, ribosomes endoplasmic reticula, inactive micropores, amylopectin bodies, lipid bodies, dense bodies, and crystalloid bodies. Merozoites were produced by endodyogeny. Ultrastructural events associated with merozoite production by type-1 meronts are described.
Differential Control of T Regulatory Cell Proliferation and Suppressive Activity by Mature Plasmacytoid versus Conventional Spleen Dendritic Cells (2008)

Anergy and suppression are cardinal features of CD4(+)CD25(+)Foxp3(+) T cells (T regulatory cells (Treg)) which have been shown to be tightly controlled by the maturation state of dendritic cells (DC). However, whether lymphoid organ DC subsets exhibit different capacities to control Treg is unclear. In this study, we have analyzed, in the rat, the role of splenic CD4(+) and CD4(-) conventional DC and plasmacytoid DC (pDC) in allogeneic Treg proliferation and suppression in vitro. As expected, in the absence of exogenous IL-2, Treg did not expand in response to immature DC. Upon TLR-induced maturation, all DC became potent stimulators of CD4(+)CD25(-) T cells, whereas only TLR7- or TLR9-matured pDC induced strong proliferation of CD4(+)CD25(+)Foxp3(+) T cells in the absence of exogenous IL-2. This capacity of pDC to reverse Treg anergy required cell contact and was partially CD86 dependent and IL-2 independent. In suppression assays, Treg strongly suppressed proliferation and IL-2 and IFN-gamma production by CD4(+)CD25(-) T cells induced by mature CD4(+) and CD4(-) DC. In contrast, upon stimulation by mature pDC, proliferating Treg suppressed IL-2 production by CD25(-) cells but not their proliferation or IFN-gamma production. Taken together, these results suggest that anergy and the suppressive function of Treg are differentially controlled by DC subsets.
Dynamics of hepatitis B virus clearance in chimpanzees (2005)

Mathematical modeling was performed to test the extent to which cytopathic and noncytopathic T cell effector functions contribute to resolution of hepatitis B virus (HBV) infection in three acutely infected chimpanzees. Simulations based exclusively on cytopathic functions show a poor fit to the data and would require the destruction and regeneration of approximately 11 livers for clearance to occur. In contrast, a simulation based on a combination of cytopathic and noncytopathic functions provided a significantly better fit to the data (P < 0.001) and required as much as 5-fold less destruction to clear the virus from the liver. The best fit simulation supports the notion that during the early phase of HBV clearance, noncytopathic T cell effector mechanisms inhibit viral replication and greatly shorten the half-life of the long lived covalently closed circular viral DNA transcriptional template, thereby limiting the extent to which cytopathic T cell effector functions and tissue destruction are required to terminate acute HBV infection.
Electrospun Nanofibrous Polymer Coated Magnesium Alloy for Biodegradable Implant Applications (2014)

In the present study, AZ31 magnesium alloy sheets were chemically treated and then coated with polycaprolactone (PCL) nanofibers by electrospinning technique to fabricate biodegradable magnesium based implants. PCL nanofibrous mat of average fiber thickness 110 nm covered the entire substrate after coating. Wettability studies carried by contact angle measurements indicated improved hydrophilicity for chemically treated AZ31 due to the formation of magnesium hydroxide and moderate hydrophobicity for polymer coated AZ31. Bio-mineralization and degradation studies conducted in super saturated simulated body fluids clearly showed improved corrosion resistance for both the chemically treated and polymer coated AZ31 compared with annealed AZ31. Among all the samples, nano-fiber coated AZ31 has shown excellent corrosion resistance.
Lotsizing and scheduling by batch sequencing (1994)

The discrete lotsizing and scheduling problem with setup-times is transformed into a single-machine scheduling problem, denoted as batch sequencing problem, which integrates sequence-dependent setups as well. The relationship between the lotsizing and the batch sequencing problem is analyzed. The batch sequencing problem is solved with an enumerative algorithm which is accelerated through bounding and dominance rules. Computational results show that this algorithm solves even the special case of sequence-independent setups more efficiently than a procedure for the discrete lotsizing and scheduling problem which has been recently published.
The Setup for Triangle Rasterization (1996)

Integrating the slope and setup calculationsfor triangles to the rasterizer offloads the host processor from intensive calculations and can significantly increase 3D system performance. The processing on the host is greatly reduced and much less data is passed from the host to the graphics subsystem. A setup architecture handling generalized triangle meshes and computing all necessary parameters for a high-end raster pipe­line to generate Gouraud shaded, texture- and bump­mapped triangles is described and its benefits on the final bandwidth are shown. To efficiently compute the slopes and color gradients for each triangle, some implementation aspects on division and multiplicationpipelines are discussed.
Mutational Profile of GNAQQ209 in Human Tumors (2009)

We detected the previously reported mutations in 6/13 (46%) blue naevi. Changes affecting Q209 were not found in any of the other tumors. Our data indicate that the occurrence of GNAQ mutations display a unique pattern being present in a subset of melanocytic tumors but not in malignancies of glial, epithelial and stromal origin analyzed in this study.
Mn<sub>2</sub>O<sub>3</sub>Slurry Reuse by Circulation Achieving High Constant Removal Rate (2012)

Fumed silica is widely used in SiO2 chemical mechanical polishing (CMP). In semiconductor processes, only fresh slurry is used, and used slurry is disposed. Sustainable development demands a reduction in waste. Since reuse of slurry is effective for reducing the amount of used slurry generated, we investigated the reuse of Mn2O3 slurry and conventional fumed silica slurry. In both cases, abrasive concentration decreases as reuse time increases. The removal rate for Mn2O3 slurry maintains a value 4 times that of the conventional fumed silica slurry during slurry reuse, because the removal rate for Mn2O3 slurry is almost constant for solid concentrations between 1.0 and 10 wt %. Pad conditioning was not performed for Mn2O3 slurry. The removal rate for conventional slurry decreases as the number of times of reuse increases, even when pad conditioning is appropriately performed.
Solidification and melting of mercury in a porous glass as studied by NMR and acoustic techniques (1998)

The melting and freezing phase transitions of mercury in a porous glass were studied by NMR and acoustic techniques. The NMR measurements provided direct information on the total amount of liquid mercury versus temperature. A depression of the phase transition temperatures and pronounced hysteresis between melting and freezing were found. Acoustic measurements showed that the freezing process was irreversible while the melting process consisted of reversible and irreversible temperature ranges. The use of longitudinal and transverse acoustic waves made it possible to obtain information about the origin of reversible and irreversible behavior upon melting. In particular, we found that the complete melting of confined mercury can be acoustically detected using only longitudinal and not transverse waves. The broadening of melting is explained by the formation of a liquid layer on the mercury solid surface, and freezing was driven by the pore geometry with no visible precursor effects.
Cobicistat versus ritonavir boosting and differences in the drug–drug interaction profiles with co-medications (2016)

Nearly all HIV PIs and the integrase inhibitor elvitegravir require a pharmacokinetic enhancer in order to achieve therapeutic plasma concentrations at the desired dose and frequency. Whereas ritonavir has been the only available pharmacokinetic enhancer for more than a decade, cobicistat has recently emerged as an alternative boosting agent. Cobicistat and ritonavir are equally strong inhibitors of cytochrome P450 (CYP) 3A4 and consequently were shown to be equivalent pharmacokinetic enhancers for elvitegravir and for the PIs atazanavir and darunavir. Since cobicistat is a more selective CYP inhibitor than ritonavir and is devoid of enzyme-inducing properties, differences are expected in their interaction profiles with some co-medications. Drugs whose exposure might be altered by ritonavir but unaltered by cobicistat are drugs primarily metabolized by CYP1A2, CYP2B6, CYP2C8, CYP2C9 and CYP2C19 or drugs undergoing mainly glucuronidation. Thus, co-medications should be systematically reviewed when switching the pharmacokinetic enhancer to anticipate potential dosage adjustments.
Cardiac Amyloidosis (2009)

Amyloidosis is a clinical disorder caused by the extracellular deposition of misfolded, insoluble aggregated protein with a characteristic ss pleated sheet configuration that produces apple-green birefringence under polarized light when stained with Congo red dye. The spectrum of organ involvement can include the kidneys, heart, blood vessels, central and peripheral nervous systems, liver, intestines, lungs, eyes, skin, and bones. Cardiovascular amyloidosis can be primary, a part of systemic amyloidosis, or the result of chronic systemic disease elsewhere in the body. The most common presentations are congestive heart failure because of restrictive cardiomyopathy and conduction abnormalities. Recent developments in imaging techniques and extracardiac tissue sampling have minimized the need for invasive endomyocardial biopsy for amyloidosis. Cardiac amyloidosis management will vary depending on the subtype but consists of supportive treatment of cardiac related symptoms and reducing the amyloid fibrils formation attacking the underlying disease. Despite advances in treatment, the prognosis for patients with amyloidosis is still poor and depends on the underlying disease type. Early diagnosis of cardiac amyloidosis may improve outcomes but requires heightened suspicion and a systematic clinical approach to evaluation. Delays in diagnosis, uncertainties about the relative merits of available therapies, and difficulties in mounting large-scale clinical trials in rare disorders combine to keep cardiac amyloidosis a challenging problem. This review outlines current approaches to diagnosis, assessment of disease severity, and treatment of cardiac amyloidosis.
Solid-phase synthesis of O-phosphorothioylserine- and -threonine-containing peptides as well as of O-phosphoserine- and -threonine-containing peptides (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolid-phase synthesis of O-phosphorothioylserine- and -threonine-containing peptides as well as of O-phosphoserine- and -threonine-containing peptidesDries B. A. De Bont, Wilna J. Moree, Jacques H. Van Boom, and Rob M. J. LiskampCite this: J. Org. Chem. 1993, 58, 6, 1309–1317Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/jo00058a006https://doi.org/10.1021/jo00058a006research-articleACS PublicationsRequest reuse permissionsArticle Views299Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts