gebhart/patrepeval huggingface dataset:
HMR 외식소비성향이 지각된 유용성 및 행동의도에 미치는 영향 (2017)

본 연구는 1인 가구, 맞벌이 가구 및 여성의 경제 참여율 증가에 사회 구조적인 변화로 인한 지속적으로 성장하고 있는 HMR에 관한 외식소비자들의 소비행동에 대해 살펴보았다. 이에 본 연구는 HMR에 대한 구매 경험이 있는 외식소비자를 대상으로 11월 초에 1주일간 자기기입식과 온라인 설문을 통해서 진행되었다. 본 연구의 가설 검증을 위해서 확인적...
Biosynthetic thiolase from Zoogloea ramigera. II. Inactivation with haloacetyl CoA analogs. (1987)

The thiolase involved in biosynthesis of poly-beta-hydroxybutyrate in Zoogloea ramigera generates an acetyl-enzyme species during catalysis. Up to 0.86 [14C] acetyl eq/subunit of this homotetrameric enzyme is accumulated by acid precipitation in the presence of [14C]acetyl-CoA. Gel filtration of the same solutions produced only 7% acetyl-enzyme suggesting hydrolytic lability of the acetyl-enzyme during the 10-min isolation at 4 degrees C. In an effort to identify active site residues which may function as basic groups to deprotonate at C-2 of acetyl-CoA to generate the required nucleophilic equivalent in carbon-carbon bond formation, we have prepared and tested haloacetyl-thioesters, oxoesters, and amides in the panthetheine pivalate series (Davis, J. T., Moore, R. N., Imperiali, B., Pratt, A. J., Kobayashi, K., Masamune, S., Sinskey, A. J., and Walsh, C. T. (1987) J. Biol. Chem. 262, 82-89). The [14C]bromoacetyl-oxoester alkylatively inactivates thiolase irreversibly with stoichiometric incorporation of four labels/tetramer. Determination of amino acid composition of the radiolabeled tryptic peptide indicated trapping of Cys-89 (Peoples, O. P., Masamune, S., Walsh, C. T., and Sinskey, A. J. (1987) J. Biol. Chem. 262, 97-102), the same residue modified by iodoacetamide. When the bromoacetyl-thioester was used, inactivation was pH-dependent. The data are consistent with the competition of two processes, acylation, and alkylation. Direct (rather than secondary) alkylation of thiolase by the inactivator accounts for the significant 14C incorporation into thiolase with the thioester labeled with [14C] in the pantetheine pivalate moiety. It appears likely that the haloacetyl analogs described herein should be generally useful for affinity labeling other enzymes using acetyl-CoA as a substrate.
Natural Listening over Headphones in Augmented Reality Using Adaptive Filtering Techniques (2015)

Augmented reality (AR), which composes of virtual and real world environments, is becoming one of the major topics of research interest due to the advent of wearable devices. Today, AR is commonly used as assistive display to enhance the perception of reality in education, gaming, navigation, sports, entertainment, simulators, etc. However, most of the past works have mainly concentrated on the visual aspects of AR. Auditory events are one of the essential components in human perceptions in daily life but the augmented reality solutions have been lacking in this regard till now compared to visual aspects. Therefore, there is a need of natural listening in AR systems to give a holistic experience to the user. A new headphones configuration is presented in this work with two pairs of binaural microphones attached to headphones (one internal and one external microphone on each side). This paper focuses on enabling natural listening using open headphones employing adaptive filtering techniques to equalize the headset such that virtual sources are perceived as close as possible to sounds emanating from the physical sources. This would also require a superposition of virtual sources with the physical sound sources, as well as ambience. Modified versions of the filtered-x normalized least mean square algorithm (FxNLMS) are proposed in the paper to converge faster to the optimum solution as compared to the conventional FxNLMS. Measurements are carried out with open structure type headphones to evaluate their performance. Subjective test was conducted using individualized binaural room impulse responses (BRIRs) to evaluate the perceptual similarity between real and virtual sounds.
Context-Aware Active Authentication Using Smartphone Accelerometer Measurements (2014)

While body movement patterns recorded by a smartphone accelerometer are now well understood to be discriminative enough to separate users, little work has been done to address the question of if or how the position in which the phone is held affects user authentication. In this work, we show through a combination of supervised learning methods and statistical tests, that there are certain users for whom exploitation of information of how a phone is held drastically improves classification performance. We propose a two-stage authentication framework that identifies the location of the phone before performing authentication, and show its benefits based on a dataset of 30 users. Our work represents a first step towards bridging the gap between accelerometer-based authentication systems analyzed from the context of a laboratory environment and a real accelerometer-based authentication system in the wild where phone positioning cannot be assumed.
Comparison of Methods for Improving Wood (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of Methods for Improving WoodLouis Klein, Henry Grinsfelder, and S. D. BaileyCite this: Ind. Eng. Chem. 1944, 36, 3, 252–256Publication Date (Print):March 1, 1944Publication History Published online1 May 2002Published inissue 1 March 1944https://doi.org/10.1021/ie50411a015RIGHTS & PERMISSIONSArticle Views51Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (723 KB) Get e-Alerts
Bactericidal activity of lansoprazole and omeprazole against Helicobacter pylori in vitro. (1998)

The minimum inhibitory concentrations of 39 Helicobacter pylori strains against antibiotics (ampicillin, tetracycline, metronidazole), colloidal bismuth subcitrate and proton pump inhibitors were assessed by the agar dilution method. 20.5% of the strains were metronidazole resistent. The comparison of the bactericidal action of omeprazole and lansoprazole in a killing curve assay showed a dose-dependent reduction of viable bacteria after 24 h, lansoprazole being more effective than omeprazole. Under varying pH conditions, the antibacterial activity of lansoprazole was limited to a pH range of 6-7, reducing bacterial numbers up to 4 logarithmical steps within 24 h.
Novel Mechanism of MDA-7/IL-24 Cancer-Specific Apoptosis through SARI Induction (2013)

Subtraction hybridization combined with induction of cancer cell terminal differentiation in human melanoma cells identified melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) and SARI (suppressor of AP-1, induced by IFN) that display potent antitumor activity. These genes are not constitutively expressed in cancer cells and forced expression of mda-7/IL-24 (Ad.mda-7) or SARI (Ad.SARI) promotes cancer-specific cell death. Ectopic expression of mda-7/IL-24 induces SARI mRNA and protein in a panel of different cancer cells, leading to cell death, without harming corresponding normal cells. Simultaneous inhibition of K-ras downstream extracellular signal-regulated kinase 1/2 signaling in pancreatic cancer cells reverses the translational block of MDA-7/IL-24 and induces SARI expression and cell death. Using SARI-antisense-based approaches, we demonstrate that SARI expression is necessary for mda-7/IL-24 antitumor effects. Secreted MDA-7/IL-24 protein induces antitumor "bystander" effects by promoting its own expression. Recombinant MDA-7/IL-24 (His-MDA-7) induces SARI expression, supporting the involvement of SARI in the MDA-7/IL-24-driven autocrine loop, culminating in antitumor effects. Moreover, His-MDA-7, after binding to its cognate receptors (IL-20R1/IL-20R2 or IL-22R/IL-20R2), induces intracellular signaling by phosphorylation of p38 MAPK, leading to transcription of a family of growth arrest and DNA damage inducible (GADD) genes, culminating in apoptosis. Inhibition of p38 MAPK fails to induce SARI following Ad.mda-7 infection. These findings reveal the significance of the mda-7/IL-24-SARI axis in cancer-specific killing and provide a potential strategy for treating both local and metastatic disease.
A Novel HTS PM Vernier Motor for Direct-Drive Propulsion (2010)

In this paper, a novel high-temperature superconductor (HTS) permanent magnet (PM) vernier motor is proposed for direct-drive propulsion, which can directly offer the low-speed high-torque capability and the high-speed rotating field design to eliminate the gearing mechanism and maximize the power density, respectively. The key is to newly introduce HTS bulks to flux-modulation poles that can effectively modulate between the high-speed rotating field of armature windings and the low-speed rotating field of the PM outer rotor. Also, the use of HTS bulks can greatly reduce the flux leakage and hence improve the torque density. Based on using the finite element method, the motor performances are analysed. Hence, the validity of the proposed motor is verified.
Establishment of an Experimental System for the Study of Tracheary Element Differentiation from Single Cells Isolated from the Mesophyll of <i>Zinnia elegans</i> (1980)

Single cells were isolated mechanically from the mesophyll of adult plants and of seedlings of Zinnia elegans L. cv. Canary bird. When single cells isolated from the first leaves of seedlings were cultured in a liquid medium in the dark with rotation, they differentiated to tracheary elements with a reasonable degree of synchrony in the 24-hour period between days 2 and 3 after culture. The proportion of tracheary elements as a percentage of total cells reached nearly 30% 3 days after culture. Factors favoring cytodifferentiation were certain optimum levels of both alpha-naphthalene-acetic acid (0.1 milligram per liter) and benzyladenine (1 milligram per liter), a low concentration of ammonium chloride (0 to 1 millimolar), and an initial cell population density in the range 0.4 to 3.8 x 10(5) cells/ml. It was possible to follow analytically the sequence of cytodifferentiation in individual cells in this system.
IGF1 and NRG1 Enhance Proliferation, Metabolic Maturity, and the Force-Frequency Response in hESC-Derived Engineered Cardiac Tissues (2017)

Insulin-like growth factor 1 (IGF1) and neuregulin-1<i>β</i> (NRG1) play important roles during cardiac development both individually and synergistically. In this study, we analyze how 3D cardiac tissue engineered from human embryonic stem cell- (hESC-) derived cardiomyocytes and 2D-plated hESC-cardiomyocytes respond to developmentally relevant growth factors both to stimulate maturity and to characterize the therapeutic potential of IGF1 and NRG1. When administered to engineered cardiac tissues, a significant decrease in active force production of ~65% was measured in all treatment groups, likely due to changes in cellular physiology. Developmentally related processes were identified in engineered tissues as IGF1 increased hESC-cardiomyocyte proliferation 3-fold over untreated controls and NRG1 stimulated oxidative phosphorylation and promoted a positive force-frequency relationship in tissues up to 3 Hz. hESC-cardiomyocyte area increased significantly with NRG1 and IGF1 + NRG1 treatment in 2D culture and gene expression data suggested increased cardiac contractile components in engineered tissues, indicating the need for functional analysis in a 3D platform to accurately characterize engineered cardiac tissue response to biochemical stimulation. This study demonstrates the therapeutic potential of IGF1 for boosting proliferation and NRG1 for promoting metabolic and contractile maturation in engineered human cardiac tissue.
Control of variable-speed wind turbines: standard and adaptive techniques for maximizing energy capture (2006)

This article considers an adaptive control scheme previously developed for region 2 control of a variable speed wind turbine. In this paper, the question of theoretical stability of the torque controller is addressed, showing that the rotor speed is asymptotically stable under the torque control law in the constant wind speed input case and L/sub 2/ stable with respect to time-varying wind input. Further, a method is derived for selecting /spl gamma//sub /spl Delta/M/ in the gain adaptation law to guarantee convergence of the adaptive gain M to its optimal value M*.
MK-4815, a Potential New Oral Agent for Treatment of Malaria (2012)

Malaria continues to have a significant impact on the health of the developing world. Efforts to combat this disease now focus on combination therapy in order to stem the emergence of resistant parasites. Continued efforts are needed to discover and develop new agents for use in combination antimalarial regimens. MK-4815 is a small molecule with antimalarial activity that was identified from a large pharmaceutical compound collection using a semiautomated version of a well-established in vitro assay for the erythrocytic stages of Plasmodium falciparum. In vitro studies indicate that the compound selectively accumulates in infected red blood cells and is most effective against the metabolically active late trophozoite/early schizont stages. A variety of drug-resistant field isolates of P. falciparum were found to be as sensitive to MK-4815 as the wild-type lines. MK-4815 is orally active in a P. berghei mouse model of acute malaria. In this model, where untreated animals succumb to infection 10 to 12 days postinfection, MK-4815 was completely curative when given as a single dose of 50 mg/kg, 2 doses of 25 mg/kg, or 4.5 doses of 12.5 mg/kg. In pharmacokinetic studies with mice and rhesus monkeys, MK-4815 demonstrated oral bioavailability and low clearance. In addition, MK-4815 is inexpensive to synthesize, an important characteristic for providing affordable antimalaria therapy to the developing world. The attractive biological and pharmaceutical profile of MK-4815 demonstrates its potential for use in combination with other agents in the fight against malaria.
Global optimization using chaos in a quasi-steepest descent method (1997)

In the continuous time model of the Hopfield neural network, which is one of the recurrent-type neural networks, the minimization of a quadratic objective function is carried out by the quasi-steepest descent method with decision variables in the upper and lower limits. This paper describes a quasi-steepest descent method in which arbitrary objective functions are selected. It is shown also that when a quasi-steepest descent method is made discrete under a certain sampling condition, the trajectory becomes chaotic. In addition, a method of applying the chaotic characteristics to the global optimization for a constrained optimization problem with upper and lower limits will be shown. The effectiveness of this method will be demonstrated numerically. © 1997 Scripta Technica, Inc. Electron Comm Jpn Pt 3, 80(4): 60–70, 1997
Deactivation of Solid Phase Epitaxy-Activated Boron Ultrashallow Junctions (2005)

International audience
Structure of Phenanthraquinoneimide Anhydride-Some New Transformations (1979)

Department of Chemistry, Berhampur University, Berhampur-760 007, Orissa, India <em>Manuscript received 4 December 1978, revised 25 April 1979, accepted 6 October 1979</em> The structure of phenanthiaquinoneimide anhydride (PQIA), is confirmed to be 10 H-dibenzo (c, e)-phenanthro-(9', 10' : 4, 5)-imidazo (1, 2-a) azepine-10-one. A refiuxing solution of PQIA in methanolic potassium hydroxide gave an amorphous insoluble acid which was confirmed to be 2'-(1 H-phenanthro-[9, 10-d]-imidazol-2-yl)-2- biphenyl carboxylic acid by spectral analysis and comparison with authentic sample. Decarboxylation of this acid resulted in the formation of 2-hiphenylyl-phenanthrimidazole which was indirectly synthesized. Phanquone on treatment with ammonium acetate-acetic acid gave phanquinic acid similar to the transformation observed in case of phenanthraquinone<strong>.</strong>
A two-dimensional scanning ocular fluorophotometer. (1985)

For certain studies of the dynamics of fluorescein in the anterior segment of the eye it would be advantageous to measure fluorescent intensity from several anatomic regions of the cornea and anterior chamber simultaneously or in rapid succession. In the present paper we describe a device called a two-dimensional scanning ocular fluorophotometer that we have designed and built to measure fluorescein concentration in a horizontal section through the cornea and anterior chamber. The 488-nm wavelength beam of an argon laser is mechanically scanned through the target area (70 microW total power at the eye) and fluorescent light is measured with a photon-counting photomultiplier tube. A single anterior-posterior scan requires 100 msec and is divided into 33 sample time periods of 3 msec each. Thirty anterior-posterior scans are made within 3 sec. A two-dimensional array of fluorescein concentration is reconstructed from the data. Concentrations ranging from 3 X 10(-10) gm/ml to 3 X 10(-6) g/ml are measured in a single scan. Examples of scans through the anterior chamber and cornea after topical and systemic administration of fluorescein are presented. These scans illustrate how this instrument can be used to measure two types of regional differences in fluorescein concentration, the "pupillary aqueous bubble" following topical administration and the radial concentration gradient in the cornea following systemic administration.
Dendrites Impact the Encoding Capabilities of the Axon (2014)

This study highlights a new and powerful direct impact of the dendritic tree (the input region of neurons) on the encoding capability of the axon (the output region). We show that the size of the dendritic arbors (its impedance load) strongly modulates the shape of the action potential (AP) onset at the axon initial segment; it is accelerated in neurons with larger dendritic surface area. AP onset rapidness is key in determining the capability of the axonal spikes to encode (phase lock to) rapid changes in synaptic inputs. Hence, our findings imply that neurons with larger dendritic arbors have improved encoding capabilities. This "dendritic size effect" was explored both analytically as well as numerically, in simplified and detailed models of 3D reconstructed layer 2/3 cortical pyramidal cells of rats and humans. The cutoff frequency of spikes phase locking to modulated inputs increased from 100 to 200 Hz in pyramidal cells of young rats to 400-600 Hz in human cells. In the latter case, phase locking reached close to 1 KHz in in vivo-like conditions. This work highlights new and functionally profound cross talk between the dendritic tree and the axon initial segment, providing new understanding of neurons as sophisticated nonlinear input/output devices.
A liquid biopsy to detect multidrug resistance and disease burden in multiple myeloma (2020)

Multiple myeloma is an incurable cancer of bone marrow plasma cells, with a 5-year survival rate of 43%. Its incidence has increased by 126% since 1990. Treatment typically involves high-dose combination chemotherapy, but therapeutic response and patient survival are unpredictable and highly variable-attributed largely to the development of multidrug resistance (MDR). MDR is the simultaneous cross-resistance to a range of unrelated chemotherapeutic agents and is associated with poor prognosis and survival. Currently, no clinical procedures allow for a direct, continuous monitoring of MDR. We identified circulating large extracellular vesicles (specifically microparticles (MPs)) that can be used to monitor disease burden, disease progression and development of MDR in myeloma. These MPs differ phenotypically in the expression of four protein biomarkers: a plasma-cell marker (CD138), the MDR protein, P-glycoprotein (P-gp), the stem-cell marker (CD34); and phosphatidylserine (PS), an MP marker and mediator of cancer spread. Elevated levels of P-gp<sup>+</sup> and PS<sup>+</sup> MPs correlate with disease progression and treatment unresponsiveness. Furthermore, P-gp, PS and CD34 are predominantly expressed in CD138<sup>-</sup> MPs in advanced disease. In particular, a dual-positive (CD138<sup>-</sup>P-gp<sup>+</sup>CD34<sup>+</sup>) population is elevated in aggressive/unresponsive disease. Our test provides a personalised liquid biopsy with potential to address the unmet clinical need of monitoring MDR and treatment failure in myeloma.
Object-oriented techniques in hardware design (1994)

We focus on using object-oriented techniques to improve the hardware design process. The advantages of these techniques for hardware design include: improved modifiability and maintainability of models; easy component instantiation with different parameters; quick composition of new components; the ability to identify and reuse common components; the ability to tailor general-purpose components to more specialized components; support of dynamic object creation and destruction; and the possibility of employing existing software synthesis and verification techniques. We illustrate the application of object-oriented techniques using a load-store, reduced instruction-set processor that contains a local memory. The instruction set consists of 22 instructions, which require one or two 16-bit words. Arithmetic is performed in two's complement. We use C++ to demonstrate the usefulness of object-oriented techniques, not to provide arguments for or against its use in hardware modeling and design.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The synthesis of SQ‐14225‐<sup>14</sup>C [N‐[(S)‐2‐methyl‐3‐mercaptopropanoyl‐1‐<sup>14</sup>C]‐L‐proline] (1981)

Abstract The preparation of SQ‐14225‐ 14 C, anti‐hypertensive drug, is described. The starting material, methacrylic acid‐1‐ 14 C, was prepared in a high yield by carbonation of the corresponding Grignard reagent with 14 CO 2 . The final product was obtained from the acid through a four step synthesis with specific activity of 3.20 mCi/mmol. The overall radiochemical yield was 8.0% based on Ba 14 CO 3 .
Infrared Video Viewing (1978)

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Unveiling the hidden dangers of public IP addresses in 4G/LTE cellular data networks (2014)

While it is often convenient for mobile cellular devices to have a public IP address, we show that such devices are vulnerable to stealthy malicious attacks. In particular, we show with experiments on three 4G/LTE cellular data networks in Singapore that it is easy for an attacker to initiate three different types of attacks on such mobile devices: (i) data quota drain, (ii) DoS flooding, and (iii) battery drain. Our experiments show that a potential attacker can completely exhaust the monthly data quota within a few minutes, completely choke the data connection of a mobile subscriber with a data stream of just 3 Mb/s, and increase the battery drain rate by up to 24 times. Finally, we argue that a simple proxy-based firewall with a secret IP address would be an effective and feasible defense against such potential attacks.