gebhart/patrepeval huggingface dataset:
Histological Analysis of Murine Colitis Induced by Dextran Sulfate Sodium of Different Molecular Weights. (2000)

In this study, we examined the relationship between the molecular weight of dextran sulfate sodium (DSS) and the features of colitis in a DSS-induced mouse model of human ulcerative colitis. DSS at three different molecular weights, 5 kD, 40 kD and 500 kD, was used in this study. DSS was administered in drinking water at 5% (w/v) to 6-7-week-old female BALB/c mice. After 7 days of treatment with DSS, the large intestine was examined histopathologically. Colitis was characterized by a loss of crypts, infiltration of inflammatory cells into the mucosa and submucosa, edema of the submucosa, erosion and ulceration and was observed in mice given the 5 kD and 40 kD forms but not the 500 kD. In the 5 kD group, colitis was observed predominantly in the cecum and upper colon. Colitis in the 40 kD group was more severe than that in the 5 kD group, and in the 40 kD group it was more severe in the lower colon than in the upper colon. These findings suggest the molecular weight of DSS to be an important factor in the murine model of colitis.
A haze removal module for mutlispectral satellite imagery (2009)

Ever-present spatial varying haze contamination in satellite scenes limits applications, especially urban remote sensing using visible and near infrared bands of low temporal resolution multispectral satellite imageries. We introduce a haze removal module coded in IDL language (used with ENVI software) which is a three-step framework comprised of haze detection, haze perfection and haze removal. The framework is based on several previous researches, loose and open, so that users can pick any method contained in each step or develop and use their own methods. Some TM and QuickBird images are present for visual assessment. Shortcoming of this module is too much human intervention on parameter determination and further search should aim at automation and more new methods in each step.
Modification of host cell phagosomes by Toxoplasma gondii involves redistribution of surface proteins and secretion of a 32 kDa protein. (1988)

Toxoplasma gondii resists endocytic processing within host cell phagosomes that are modified by a prominent membranous network which forms the interface between host cell and the enclosed parasite. The formation of this intravacuolar network involves redistribution of the major outer membrane proteins of the Toxoplasma cell, consisting of 41, 35, 29, 22 kDa species, as shown by radioimmunoprecipitation, sodium dodecyl sulfate polyacrylamide gel electrophoresis, and immunogold EM labeling using monoclonal antibodies (mAbs) to T. gondii. In addition, the major 32 kDa protein found in the purified intravacuolar networks was recognized by mAb 1G5 which does not react with the surface of intact Toxoplasma cells. Immunoperoxidase EM using mAb 1G5 indicated that the 32 kDa protein is a constituent of electron-dense vacuoles within the Toxoplasma cell, in addition to being a prominent component of the intravacuolar network. Thus, assembly of the intravacuolar network appears to involve regulated release of the 32 kDa protein in conjunction with shedding of surface membrane proteins by the parasite. Our results suggest that the structural modifications of host cell phagosomes by T. gondii are precisely regulated events that follow invasion and consequently may contribute to intracellular survival.
Structural and thermal characterization of metal halides doped polypyrrole (2008)

Polypyrrole and its metal halide composites have been synthesized by chemical oxidation polymerization technique with ammonium peroxisulphate (oxidant) in aqueous hydrochloric acid medium, structural characterization of polypyrrole samples S1 (100% Co), S2 (25%Ni -75%Co), S3 (50%Ni -50%Co), S4 (75%Ni - 25%Co) and S5 (100%Ni) has been made by XRD and FTIR spectroscopy. Thermal transport properties such as effective thermal conductivity (λ e ) and effective thermal diffusivity (Χ e ) of these samples have been measured simultaneously at room temperature and normal pressure using transient plane source (TPS) technique. The values of effective thermal conductivity and effective thermal diffusivity are found higher in all the above-mentioned samples except sample S3 (50%Ni-50%Co). This result can be explained on the basis of bonding of cobalt and nickel with polypyrrole matrix during their polymerization.
Dynamic pricing in a two-class queueing system with arrival and service rate control (2020)

Abstract Dynamic pricing in a two-class queueing system with adjustable arrival and service rates is considered. We initially take adjustable rates into account to maximize the long-run average social welfare and further establish matched dynamic prices. For the rate-setting problem, we apply sensitivity-based optimization theory and an iterative algorithm to investigate the optimal arrival and service rates of the two classes of customers. Next, we apply the results obtained from the rate-setting problem to find the expected delay time using a recursive algorithm and explicitly determine formulae for the optimal prices of the two classes of customers. Finally, we carry out numerical experiments to illustrate our findings and the performance between two classes of customers at different levels of the holding cost. It appears that for a low holding cost, the optimal prices for the two classes of customers are monotonically increasing in the number of customers regardless of the class, but for a high holding cost, the optimal prices for the customers who have low waiting cost may drop when the number of the other class rises.
Crises de politiques et régulations cognitives : l'exemple des politiques du livre (1996)

Muller Pierre, Surel Yves. Crises de politiques et régulations cognitives : l'exemple des politiques du livre. In: Pôle Sud, n°4, 1996. Négociations, sous la direction de François Baraize . pp. 92-106.
Wrong biochemistry results (2001)

The success of analytical methods in clinical chemistry has led to a sense of security in the value of laboratory results. This is largely justified, as evidenced by the quality of laboratory performance assessed by external assurance schemes. Nevertheless, it is not widely recognised among clinicians that some biochemical tests are more prone to interference from unusual serum constituents than others—and that quality assurance schemes can do little about this.

An important example of this is tests carried out by immunoassays based on the recognition of molecules by antibodies. The antibodies are largely derived from animal sources and are typically used for measuring hormones, tumour markers, cardiac troponins, and therapeutic drugs and for viral serology.

The design of assays has evolved enormously since the discovery of immunoassay by Berson et al in 1956,1 and it is now a major analytical tool in clinical laboratories worldwide, allowing relatively minute (picomole (10−12)) amounts of analytes to be measured with unrivalled precision.

Interference …
Neutral carrier sodium ion-selective microelectrode for intracellular studies (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNeutral carrier sodium ion-selective microelectrode for intracellular studiesR. A. Steiner, M. Oehme, D. Ammann, and W. SimonCite this: Anal. Chem. 1979, 51, 3, 351–353Publication Date (Print):March 1, 1979Publication History Published online1 May 2002Published inissue 1 March 1979https://doi.org/10.1021/ac50039a008RIGHTS & PERMISSIONSArticle Views419Altmetric-Citations172LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (367 KB) Get e-Alerts Get e-Alerts
Measurement Methods to Determine Compliance with Ambient Air Quality Standards for Suspended Particles (1995)

One of the most important parts of formulating a National Ambient Air Quality Standard is specifying the measurement methods for determining and attaining compliance. The samples taken for compliance are often pushed beyond their original purpose to identify sources, to evaluate the effectiveness of controls, and to determine relationships between pollution levels and public health. A full understanding of available sampling and analysis methods is needed, as well as an analysis of their costs, before acceptable monitoring approached can be specified. This review identifies issues related to measurement methods used to determine compliance with standards, describes current and future measurement methods and their limitations, and determines the extent to which existing technology can meet short-term and long-term needs for measuring compliance.
Reducing timing channels with fuzzy time (2002)

Fuzzy time is a collection of techniques that reduces the bandwidths of covert timing channels by making all clocks available to a process noisy. Developed in response to the problems posed by high-speed hardware timing channels, fuzzy time has been implemented in the VAX security kernel. Fuzzy time has proven to be highly effective against the timing channels in the VAX security kernel. Not only does fuzzy time close the high-speed channels, it does so at a much lower-than-anticipated performance cost. It is believed that the VAX security kernal managed to meet the covert channel guidelines while maintaining a good balance between security and performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The derivation of the stresses in a pressurised pipe or cylindrical vessel with initial geometric imperfections (1988)

Several analytical methods are outlined to deal with the title problem when the vessel is free of external constraints. In essence these correspond to the Haigh equation, which provides a nonlinear relationship between the induced circumferential stress and the applied internal pressure. To make use of these analyses a survey of the cross sectional profile is required. The approach using an internal swinging arm has been found most useful. The extent to which an improved Haigh equation is valid is examined with reference to the pneumatic loading of a twin saddle supported horizontal vessel which contains imperfections and restraints at the supports.
Competitive Binding Activity of Angiotensin II Analogues in an Adrenal Cortex Radioligand-Receptor Assay (1975)

The competitive binding activities of a number of angiotensin analogues were determined in a radioligand-receptor assay employing bovine adrenal crotex homogenate and [125I] iodoangiotensin II. This assay system has been shown to provide a precise and convenient method for evaluation and comparison of the binding-inhibition potencies of angiotensin II derivatives with agonist and antagonist activities. Agonist analogues of angiotensin II showed competitive binding activities in proportion to their known biological activities upon aldosterone production by the adrenal zona glomerulosa. Thus, the [Des-Asp1] heptapeptide of angiotensin II was equipotent with the native octapeptide in terms of binding-inhibition activity, and the [Sar1] derivative of angiotensin II was more potent than the native peptide. By contrast, the [Des-Asp1, Des-Arg2] hexapeptide and the [Des-Phe8] heptapeptide showed less than 1% of the activity of angiotensin II. Angiotensin II antagonists formed by C-terminal substitution of the octapeptide with isoleucine or alanine were also found to exhibit binding-inhibition activities in proportion to their known potencies as antagonists of the action of angiotensin II upon smooth muscle. Certain antagonists, such as [1-guanidoacetic, 8-isoleucine]-angiotensin II and [1-sarcosine, 8-isoleucine]-angiotensin II displayed significantly greater binding-inhibition potency than E1Asp1, Ileu5,-angiotensin II in the adrenal receptor system. Several, such as [Sar1, Ala8]-angiotensin II and [MeAla1, Ileu8]-antiotensin II were approximately equipotent with angiotensin II, while others such as [1-succinic acid, 8-alanine]-angiotensin II and [D-Ileu8]-angiotensin II showed no significant binding-inhibition activity. The relative binding-inhibition potencies of the antagonist peptides showed a general correlation with the pA2 values of the same components determined upon the smooth muscle response of the isolated aortic strip. The binding-inhibition potency of angiotensin II antagonists was also strongly influenced by the charge of the N-terminal residue, with enhancement of activity by more basic substituents and abolition of activity by highly acidic residues. The influence of the basicity of the N-terminus upon receptor binding was also observed with the agonist analogue [Sar1]-angiotensin II, which showed a 2- to 3-fold increase in binding-inhibition potency in comparison to native angiotensin II. The significant enhancement of binding-inhibition potency by N-terminal sarcosine substitution is attributable to higher affinity of the modified peptide for the angiotensin II receptor site, and is consistent with the increased activity of [Sar1]-angiotensin II upon smooth muscle and aldosterone production in vitro. The determination of binding-inhibition activity in the adrenal radioligand receptor assay provides a valid and convenient method for analysis of the role of binding affinity in the actions of competitive antagonists upon the responses of target cells to angiotensin II.
Effects of Amphetamine on Sexual Behavior of Male IV Drug Users in Stockholm—A Pilot Study (1992)

Sexual behavior in connection with drug use and its implications for the risk of sexual transmission of human immunodeficiency virus (HIV) among intravenous drug users (IVDUs) was investigated in a pilot study of 29 men (who injected drugs more than once a week for at least 6 months) at the Remand Prison in Stockholm from November, 1989, to January, 1990. A structured interview focusing on sexual history and current sexual behavior with and without drugs was employed. The median age of the subjects was 32 years. Six were HIV-seropositive. The main drugs presently used were amphetamine (18 men), heroin (9 men) and cocaine (2 men). Of the 29 men, 27 had experience of sexual activity while using amphetamine. Of these, 23 reported that they became more sexually excited when on amphetamine, 21 reported intensified orgasms, and 23 reported that the drug prolonged intercourse. All 29 men had been sexually active, but only 6 of the amphetamine users had had more than 10 partners during the last 3 years. Condom use was very low; it was reported by only 3 men during their last intercourse with a causal partner. The findings suggest that sexual HIV transmission among IVDUs is a clear risk, especially among amphetamine users, and that education about condom use is urgent.
Pearls: a natural history (2002)

A book with the luster and allure of its subject, Pearls is the most spectacular volume ever produced on this prized gem. Blending history, science, and the jeweler's art to celebrate these natural treasures - as in Abrams' hugely successful Amber - this lavishly illustrated volume, shimmering with new color photography and archival images, traces the natural and cultural history of pearls around the world. Published to accompany an exhibition organized by the American Museum of Natural History in New York and the Field Museum in Chicago, Pearls begins with the earliest pearl artifacts found in Mesopotamia and discusses how pearls are formed, in nature and by humans, the ways different cultures have used pearls in literature, paintings, religious objects, and sculptures, and, of course, pearls as personal adornment.
Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution (2003)

Protein phosphatase 2A (PP2A) is very versatile owing to a large number of regulatory subunits and its ability to interact with numerous other proteins. The regulatory A subunit exists as two closely related isoforms designated Aalpha and Abeta. Mutations have been found in both isoforms in a variety of human cancers. Although Aalpha has been intensely studied, little is known about Abeta. We generated Abeta-specific antibodies and determined the cell cycle expression, subcellular distribution, and metabolic stability of Abeta in comparison with Aalpha. Both forms were expressed at constant levels throughout the cell cycle, but Aalpha was expressed at a much higher level than Abeta. Both forms were found predominantly in the cytoplasm, and both had a half-life of approx. 10 h. However, Aalpha and Abeta differed substantially in their expression patterns in normal tissues and in tumour cell lines. Whereas Aalpha was expressed at similarly high levels in all tissues and cell lines, Abeta expression varied greatly. In addition, in vivo studies with epitope-tagged Aalpha and Abeta subunits demonstrated that Abeta is a markedly weaker binder of regulatory B and catalytic C subunits than Aalpha. Construction of phylogenetic trees revealed that the conservation of Aalpha during the evolution of mammals is extraordinarily high in comparison with both Abeta and cytochrome c, suggesting that Aalpha is involved in more protein-protein interactions than Abeta. We also measured the binding of polyoma virus middle tumour antigen and simian virus 40 (SV40) small tumour antigen to Aalpha and Abeta. Whereas both isoforms bound polyoma virus middle tumour antigen equally well, only Aalpha bound SV40 small tumour antigen.
Generative Adversarial Networks and Other Generative Models (2022)

Generative networks are fundamentally different in their aim and methods compared to CNNs for classification, segmentation, or object detection. They have initially not been meant to be an image analysis tool, but to produce naturally looking images. The adversarial training paradigm has been proposed to stabilize generative methods, and has proven to be highly successful -- though by no means from the first attempt. This chapter gives a basic introduction into the motivation for Generative Adversarial Networks (GANs) and traces the path of their success by abstracting the basic task and working mechanism, and deriving the difficulty of early practical approaches. Methods for a more stable training will be shown, and also typical signs for poor convergence and their reasons. Though this chapter focuses on GANs that are meant for image generation and image analysis, the adversarial training paradigm itself is not specific to images, and also generalizes to tasks in image analysis. Examples of architectures for image semantic segmentation and abnormality detection will be acclaimed, before contrasting GANs with further generative modeling approaches lately entering the scene. This will allow a contextualized view on the limits but also benefits of GANs.
Increased Peroxynitrite Activity in AIDS Dementia Complex: Implications for the Neuropathogenesis of HIV-1 Infection (1999)

Abstract Oxidative stress is suggested to be involved in several neurodegenerative diseases. One mechanism of oxidative damage is mediated by peroxynitrite, a neurotoxic reaction product of superoxide anion and nitric oxide. Expression of two cytokines and two key enzymes that are indicative of the presence of reactive oxygen intermediates and peroxynitrite was investigated in brain tissue of AIDS patients with and without AIDS dementia complex and HIV-seronegative controls. RNA expression of IL-1β, IL-10, inducible nitric oxide synthase, and superoxide dismutase (SOD) was found to be significantly higher in demented compared with nondemented patients. Immunohistochemical analysis showed that SOD was expressed in CD68-positive microglial cells while inducible nitric oxide synthase was detected in glial fibrillary acidic protein (GFAP)-positive astrocytes and in equal amounts in microglial cells. Approximately 70% of the HIV p24-Ag-positive macrophages did express SOD, suggesting a direct HIV-induced intracellular event. HIV-1 infection of macrophages resulted in both increased superoxide anion production and elevated SOD mRNA levels, compared with uninfected macrophages. Finally, we show that nitrotyrosine, the footprint of peroxynitrite, was found more intense and frequent in brain sections of demented patients compared with nondemented patients. These results indicate that, as a result of simultaneous production of superoxide anion and nitric oxide, peroxynitrite may contribute to the neuropathogenesis of HIV-1 infection.
Effect of Iron and Boron Carbide on the Densification and Mechanical Properties of Titanium Diboride Ceramics (1989)

The effect of Fe and B 4 C on the sintering behavior and mechanical properties of TiB 2 ceramics have been studied. Sintering was performed in an Ar atmosphere at 2000° using attrition‐milled TiB 2 powder (mean particle size = 0.8 μm). When a small amount of Fe (0.5 wt%) was added, abnormal grain growth occurred and the sintered density was low. In the case of B 4 C added along with 0.5 wt% Fe, however, abnormal grain growth was remarkably suppressed, and the sintered density was increased up to 95% of theoretical. But with excess Fe addition (5 wt%), B 4 C grains did not act as a grain growth inhibitor, and B 4 C grains were frequently trapped in large TiB 2 grains. The best mechanical properties were obtained for the TiB 2 –10 wt% B 4 C–0.5 wt% Fe ceramics, which exhibited a three‐point bending strength of 400 MPa and a fracture toughness of 5.5 MPa · m 1/2 .
Motor Axon Regeneration and Muscle Reinnervation in Young Adult and Aged Animals (2013)

Injuries to peripheral nerves can cause paralysis and sensory disturbances, but such functional impairments are often short lived because of efficient regeneration of damaged axons. The time required for functional recovery, however, increases with advancing age (Verdú et al., 2000; Kawabuchi et al., 2011). Incomplete or delayed recovery after peripheral nerve damage is a major health concern in the aging population because it can severely restrict a person's mobility and independence. A variety of possible causes have been suggested to explain why nervous systems in aged individuals recover more slowly from nerve damage. Potential causes include age-related declines in the regenerative potential of peripheral axons and decreases in the supply or responsivity to trophic and/or tropic factors. However, there have been few direct analyses of age-related axon regeneration. Our aim here was to observe axons directly in young and old mice as they regenerate and ultimately reoccupy denervated neuromuscular synaptic sites to learn what changes in this process are age related. We find that damaged nerves in aged animals clear debris more slowly than nerves in young animals and that the greater number of obstructions regenerating axons encounter in the endoneurial tubes of old animals give rise to slower regeneration. Surprisingly, however, axons from aged animals regenerate quickly when not confronted by debris and reoccupy neuromuscular junction sites efficiently. These results imply that facilitating clearance of axon debris might be a good target for the treatment of nerve injury in the aged.