gebhart/patrepeval huggingface dataset:
Sequence-selective interactions of transcription factor elements with tandem glucocorticoid-responsive elements at physiological steroid concentrations. (1993)

Synergism in transcription is said to occur when the combined response from two DNA elements for the binding of trans-acting factors is greater than the sum of the responses from each element in isolation. The synergism of steroid receptors with themselves or with other trans-acting factors at saturating concentrations of steroid has proved to be an important component of steroid-regulated gene transcription. We have recently described a glucocorticoid modulatory element (GME) of the rat tyrosine aminotransferase gene that, in conjunction with a trans-acting factor, modulates the transcriptional activity of receptor-glucocorticoid and -antiglucocorticoid complexes with homologous and heterologous genes and promoters (Oshima, H., and Simons, S. S., Jr. (1992) Mol. Endocrinol. 6, 416-428). We now report that, under certain circumstances, the GME displays synergistic activity with a glucocorticoid-responsive element (GRE). However, several properties of GME action are different from those previously observed for synergism. The effects of the GME were marked at subsaturating or physiological concentrations of glucocorticoids but insignificant at saturating concentrations, which are the established conditions for synergism. The GME was found to increase the agonist activity of partial antiglucocorticoids, while synergism involving antisteroids has yet to be reported. Furthermore, the GRE was active in conjunction with two tandem repeats of a GRE, which was a combination that did not support conventional synergism. Most importantly, the effects of the GME were greater than with any other trans-acting factor binding element tested, indicative of a sequence-selective activity. The efficacy of the GME was also insensitive to the spacing between elements. Thus, the GME provides a mechanism for selective transcriptional modulation by physiological concentrations of steroid, and by antisteroids, of a common class of genes that are under the control of two or more GREs.
Reactions of aromatic radical anions. VII. Kinetic study of the reaction of sodium anthracene with water (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of aromatic radical anions. VII. Kinetic study of the reaction of sodium anthracene with waterShelton Bank and Bradley BockrathCite this: J. Am. Chem. Soc. 1972, 94, 17, 6076–6083Publication Date (Print):August 1, 1972Publication History Published online1 May 2002Published inissue 1 August 1972https://pubs.acs.org/doi/10.1021/ja00772a023https://doi.org/10.1021/ja00772a023research-articleACS PublicationsRequest reuse permissionsArticle Views189Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spatiotemporal Deformable Part Models for Action Detection (2013)

Deformable part models have achieved impressive performance for object detection, even on difficult image datasets. This paper explores the generalization of deformable part models from 2D images to 3D spatiotemporal volumes to better study their effectiveness for action detection in video. Actions are treated as spatiotemporal patterns and a deformable part model is generated for each action from a collection of examples. For each action model, the most discriminative 3D sub volumes are automatically selected as parts and the spatiotemporal relations between their locations are learned. By focusing on the most distinctive parts of each action, our models adapt to intra-class variation and show robustness to clutter. Extensive experiments on several video datasets demonstrate the strength of spatiotemporal DPMs for classifying and localizing actions.
Effects of HgCl2 on CO2 Dependence of Leaf Photosynthesis: Evidence Indicating Involvement of Aquaporins in CO2 Diffusion across the Plasma Membrane (2002)

Experiments were conducted to examine whether mercury-sensitive aquaporins facilitate photosynthetic CO(2) diffusion across the plasma membrane of leaf mesophyll cells. Discs without abaxial epidermes from Vicia faba leaflets were treated with HgCl(2), an inhibitor of aquaporins. Hydraulic conductivity of the plasma membrane of these discs, measured as the weight loss of the discs in the 1 M sorbitol solution, was inhibited by sub-mM concentrations of HgCl(2) by 70 to 80%. Photosynthetic CO(2) fixation was also inhibited by the HgCl(2) treatment in a similar concentration range. When 0.3 mM HgCl(2) solution was fed to the V. faba leaflets with intact epidermes via the transpiration stream, the rate of photosynthesis on leaf area basis (A) measured at photosynthetically active photon flux density of 700 micromol m(-2) s(-1) and at leaf temperature of 25 degrees C, decreased by about 20 to 30% at any CO(2) concentration in the intercellular spaces (C(i)). However, when CO(2) concentration in the chloroplast stroma (C(c)) was calculated from fluorescence and gas exchange data and A was plotted against C(c), A at low C(c) concentrations did not differ before and after the treatment. The conductance for CO(2) diffusion from the intercellular spaces to the chloroplast stroma (g(i)) decreased to 40 and 30% of the control value, when the leaflets were fed with 0.3 mM and 1.2 mM HgCl(2), respectively. Similar results were obtained with leaves of Phaseolus vulgaris. Although effects of HgCl(2) were not specific, the present results showed that HgCl(2) consistently lowered g(i). It is, thus, probable that the photosynthetic CO(2) uptake across the plasma membrane of the mesophyll cells is facilitated by mercury-sensitive aquaporins.
<title>Development Of A New Family Of Improved Infrared (IR) Dome Ceramics</title> (1982)

A comprehensive search was made to identify ceramic materials which could be employed as IR sensor windows or IRdomes in environments conducive to severe mechanical stresses. This program, started in late 1977 under the joint sponsorship of the Defense Advanced Research Projects Agency (DARPA) and the office of Naval Research (ONR), has been reported in detail in Ref. 1 - 4 through the period ending in mid 1980. The purpose of this paper is to summarize the current status of the processing technologies being developed to realize the potentials of certain advanced materials selected for development.
A QUANTITATIVE METHOD FOR COST REIMBURSEMENT AND LENGTH OF STAY QUALITY ASSURANCE IN MULTIPLE TRAUMA PATIENTS (1994)

These models provide a valid method of reimbursement for MSI trauma for level I trauma centers, since the data imply that good care associated with survival from specific complications of MSI are the major determinants of COST, rather than the specific type of injury or the resultant ISS. Moreover, using survival and ISS plus the disease-related complications as determinants of LOS, this method can be applied to any U.S. region since local factors can be used to adjust hospital COST as a highly correlated function of LOS. This method also permits identification of LOS outliers for QA, taking into account the influence of injury complications.
Recent Advances of LTE/WiFi Coexistence in Unlicensed Spectrum (2017)

U-LTE is a new wireless technology that is currently being developed by industry and academia to offer LTE service in unlicensed spectrum. U-LTE addresses spectrum shortage from 4G LTE cellular networks by allowing them to operate in unlicensed bands. To ensure fair spectrum sharing among different wireless technologies (LTE and WiFi in particular), a number of coexistence mechanisms have been proposed. These mechanisms operate in the time, frequency, or power domains to minimize potential adverse effects from LTE. Based on these mechanisms, a number of U-LTE standards are being developed by industry. In this article, we present recent advances in this exciting area by reviewing the state-of-the-art LTE/WiFi coexistence mechanisms and show how they are incorporated into industry standards. We also point out several key challenges and open problems for future research.
Immunologic Stimulation of Mast Cells Leads to the Reversible Exposure of Phosphatidylserine in the Absence of Apoptosis (2000)

In addition to providing a means of monitoring exocytosis at the single cell level, our results indicate that PS externalization in mast cells is not necessarily related to apoptosis but could be an important feature of the degranulation process.
Highly-efficient broadband acoustic transducer for all-fibre acousto-optic devices (2003)

An acoustic transducer for excitation of acoustic waves to an optical fibre with high efficiency and smooth frequency response is demonstrated. Reducing the size of the transducer to an order of the acoustic wavelength has resulted in low power consumption and smaller efficiency variations during wavelength tuning.
A New Quercetin-Acylglucuronide from Scolymus hispanicus (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Quercetin-Acylglucuronide from Scolymus hispanicusMaria-Jesus Sanz, Maria-Carmen Terencio, Salvador Mañez, Jose-Luis Rios, and Concepcion SorianoCite this: J. Nat. Prod. 1993, 56, 11, 1995–1998Publication Date (Print):November 1, 1993Publication History Published online1 July 2004Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/np50101a022https://doi.org/10.1021/np50101a022research-articleACS PublicationsRequest reuse permissionsArticle Views233Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intermolecular-Intramolecular Polymerization of α-Diolefins by Metal Alkyl Coördination Catalysts<sup>1</sup> (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntermolecular-Intramolecular Polymerization of α-Diolefins by Metal Alkyl Coördination Catalysts1C. S. Marvel and J. K. StilleCite this: J. Am. Chem. Soc. 1958, 80, 7, 1740–1744Publication Date (Print):April 1, 1958Publication History Published online1 May 2002Published inissue 1 April 1958https://pubs.acs.org/doi/10.1021/ja01540a059https://doi.org/10.1021/ja01540a059research-articleACS PublicationsRequest reuse permissionsArticle Views302Altmetric-Citations109LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Segmentation of Nuclei in Histopathology Images by Deep Regression of the Distance Map (2018)

The advent of digital pathology provides us with the challenging opportunity to automatically analyze whole slides of diseased tissue in order to derive quantitative profiles that can be used for diagnosis and prognosis tasks. In particular, for the development of interpretable models, the detection and segmentation of cell nuclei is of the utmost importance. In this paper, we describe a new method to automatically segment nuclei from Haematoxylin and Eosin (H&E) stained histopathology data with fully convolutional networks. In particular, we address the problem of segmenting touching nuclei by formulating the segmentation problem as a regression task of the distance map. We demonstrate superior performance of this approach as compared to other approaches using Convolutional Neural Networks.
A Method of Human Plasmapheresis. (1952)

A simple method for human plasmapheresis is described. In a single patient with multiple myeloma it has been shown that the removal of 30 g of plasma protein daily can be continued without ill effect and without substantial decrease in the concentration of plasma protein for at least five weeks. Nitrogen equilibrium was maintained when the diet contained 85 g of protein per day and 2500 calories.
Site-Directed Mutagenesis of Glutamate-166 in .beta.-Lactamase Leads to a Branched Path Mechanism (1994)

Glutamate-166 of the Bacillus licheniformis beta-lactamase was specifically mutated to aspartate and cysteine in order to probe the function of this residue in catalysis. In both cases, a large decrease in activity (kcat/Km was 3.5 x 10(-5) smaller for E166C and 1 x 10(-3) smaller for E166D than for the wild-type) was observed, although the kinetics for the two mutants were very different. The pH-rate profiles for E166D and E166C reflected the ionization characteristics of the new residue at site 166. This result indicates that the ionization of Glu-166 is responsible for the acidic limb of the kcat/Km-pH profiles, and suggests that the function of Glu-166 is that of a general base catalyst. The kinetics of the E166C mutant were investigated in detail. An initial burst was observed, whose amplitude was stoichiometric with the enzyme concentration, suggesting rate-limiting deacylation of the acyl-enzyme intermediate. However, further study revealed that in the presence of 0.5 M sodium sulfate, which stabilizes the native conformational state, the magnitude of the burst corresponded to 2 equiv of enzyme. This observation, in conjunction with the limited effect of the mutation on Km, indicated that the mutation resulted in a change in the kinetic mechanism from the linear, acyl-enzyme pathway to one with a branch leading to an inactive form of the acyl-enzyme.(ABSTRACT TRUNCATED AT 250 WORDS)
Reduction of Inflammation Marker and Histopathology Changes by Polysaccharide Peptide (Ganodermalucidum) in Diabetic Rats (2015)

Background: Diabetes Mellitus (DM) is a risk factor equivalent to Coronary Artery Disease (CAD). DM with hyperglycemia and insulin resistance enhances inflammation in vascular wall that accelerates atherosclerosis. Inflammatory cytokines are involved in both these diseases either DM or CAD. Anti-inflammation agent is needed to attenuate the inflammation. Objective: This study aimed to evaluate polysaccharide peptide (PsP) of the extract of Ganodermalucidum as an anti-inflammation that inhibits the process of atherogenesis in rats model of diabetes. Methods: The study was experimental study design. Thirty Wistar rats were divided into 5 groups: 1 group of normal rats as control group and 4 groups with High Fat Diet (HFD) and low dose streptozotocin (30 mg/kgBW) injection sc,treated with placebo and PsP dose 50,150,300 mg/KgBW respectively. Parameters measured are level of interleukin - 6 (IL - 6), high sensitive C-reactive protein (hsCRP),atherosclerotic plaque area, perivascular adiposite (PVA). Result: After 5 weeks of treatment found significant lower levels of IL – 6 (p = 0.000), atherosclerosis plaque area (p = 0.000), PVA (p = 0.000) and decreased of hsCRP (p = 0.079) descriptively in the treatment group PSP 150 and 300 mg/kgBW. Conclusion: Based on this study, PsP is a promising novel anti-inflammation to inhibit the process of atherogenesis in a mouse model of diabetes induced by HFD and streptozotocin.
Preliminary grouping of mutacins (1995)

All the mutacins described so far have been shown to be different substances. To classify 86 mutacinogenic strains, we determined their activity spectra towards 12 standard oral streptococci and towards themselves, using a deferred antagonism test. The mutacinogenic strains could be grouped into 15 mutacinotypes according to their activity spectra against the 12 standard oral streptococci. By combining the results of their activity spectra and their sensitivity patterns amongst themselves, we defined 24 mutacin groups. Using the 24 type strains corresponding to these groups as producers and as indicators, it will be easier to classify new mutacin-producing isolates.Key words: bacteriocin, mutacin, Streptococcus mutans, inhibitory substance.
Birth Defects among Children of Nurse-anesthetists (1974)

A survey of 621 female nurse-anesthetists in Michigan was performed to determine the incidence of birth defects among the offspring of this group. Two separate mailings and telephone interviews resulted in a response rate of 84.5 per cent. Of children whose mothers worked during pregnancy, 16.4 per
Proliferation of Schwann cells and regulation of cyclin D1 expression in an animal model of Charcot‐Marie‐Tooth disease type 1A (2002)

Overexpression of PMP22 is responsible for the most common form of inherited neuropathy, Charcot-Marie-Tooth disease (CMT) type 1A. The PMP22-transgenic rat (CMT rat) is an animal model of CMT1A, and its peripheral nerves show the characteristic features of ongoing demyelination and remyelination that is also seen in CMT1A patients. Since Schwann cell proliferation is a prominent feature of peripheral nerves in inherited peripheral neuropathies, we examined proliferation and the expression of cyclin D1 in CMT rats. D-type cyclins are required for the initial steps in cell division and nuclear import is crucial for the function of cyclin D1 in promoting cell proliferation. Like normal myelinating Schwann cells in wild-type rats, remyelinating Schwann cells in CMT rats show perinuclear cyclin D1 expression. Schwann cells with nuclear cyclin D1 expression, as well as proliferating Schwann cells, were both associated with demyelinated axonal segments. Supernumerary onion bulb Schwann cells, however, do not express cyclin D1 and were not proliferating. Thus, cyclin D1 expression and its subcellular localization correlate directly with distinct physiological states of Schwann cells in this animal model of CMT1A.
Specific Leaf Area and Dry Matter Content Estimate Thickness in Laminar Leaves (2005)

The overall slope and intercept of the relationship were not significantly different from one and zero, respectively, and the residual standard error was 0.11. Only two of the eight datasets displayed a significant difference in the intercepts, and the only significant difference among the most represented growth forms was for trees. LT can therefore be estimated by (SLA x LDMC)(-1), allowing leaf thickness to be derived from easily and widely measured leaf traits.
Beamformed nearfield imaging of a simulated coronary artery containing a stenosis (1998)

This paper is concerned with the potential for the detection and location of an artery containing a partial blockage by exploiting the space-time properties of the shear wave field in the surrounding elastic soft tissue. As a demonstration of feasibility, an array of piezoelectric film vibration sensors is placed on the free surface of a urethane mold that contains a surgical tube. Inside the surgical tube is a nylon constriction that inhibits the water flowing through the tube. A turbulent field develops in and downstream from the blockage, creating a randomly fluctuating pressure on the inner wall of the tube. This force produces shear and compressional wave energy in the urethane. After the array is used to sample the dominant shear wave space-time energy field at low frequencies, a nearfield (i.e., focused) beamforming process then images the energy distribution in the three-dimensional solid. Experiments and numerical simulations are included to demonstrate the potential of this noninvasive procedure for the early identification of vascular blockages-the typical precursor of serious arterial disease in the human heart.
A METHOD OF CORONARY RETROPERFUSION FOR THE TREATMENT OF ACUTE MYOCARDIAL ISCHEMIA. (1978)

A method of retrograde perfusion of the myocardium has been developed in dogs. It consists of a double lumen balloon-tipped catheter inserted transvenously into the coronary sinus, with one lumen connected to a roller pump, the other to a helium counterpulsing pump. Oxygenated heparinized blood is obtained from the femoral artery and pumped continuously into the coronary sinus at a pressure of 50-75 mm Hg. The balloon is inflated during diastole, sealing the coronary sinus and promoting retrograde flow, and is deflated during systole, allowing blood drainage into the right atrium and preventing venous congestion. Thirteen anesthetized open-chest dogs were subjected to 15 minutes of proximal LAD artery occlusion and 30 minutes of diastolic coronary sinus perfusion (DCSP). The area of ischemia was mapped by means of platinum electrodes capable of simultaneously measuring myocardial tissue oxygen tension M(p)O(2)) and electrograms. Reduction of M(p)O(2) with simultaneous elevation of the ST segment on the corresponding electrogram was considered an indication of ischemia. Diastolic coronary sinus perfusion improved myocardial oxygen tension in the ischemic myocardium, reduced ST segment elevation, and tended to restore arterial blood pressure. Histologically, there was no intramyocardial hemorrhage.