gebhart/patrepeval huggingface dataset:
Early statin therapy in patients with acute coronary syndrome. (2005)

P atients who survive an acute coronary syndrome (ACS; myocardial infarction [MI] or unstable angina) are at a high risk of recurrent events. In this context, recent data from observational, as well as from randomised clinical trials, support an early benefit from statins started during hospital admission for an ACS in addition to improving long-term compliance with statin therapy. The Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study addressed the question whether early initiation of treatment with atorvastatin reduced the occurrence of major cardiovascular events (death, nonfatal acute MI, cardiac arrest with resuscitation or recurrent myocardial ischaemia requiring emergency rehospitalisation) in patients with ACS. Adults (n=3086) admitted for an ACS were randomly assigned to atorvastatin 80 mg/d or placebo 24 to 96 h after an ACS and were followed-up for 16 weeks. Treatment with atorvastatin reduced the incidence of recurrent myocardial ischaemia requiring emergency rehospitalisation in the first 16 weeks compared to placebo (6.2% vs. 8.4%, p=0.02), but there were no significant differences between the two groups in the incidence of death, nonfatal acute MI or cardiac arrest with resuscitation. In the Pravastatin in Acute Coronary Treatment (PACT) trial, 3408 patients with an ACS were randomly assigned to 4 weeks’ treatment with pravastatin (20 to 40 mg/day) or matching placebo within 24 h after the onset of symptoms. Pravastatin treatment resulted in a non-significant decrease (6.4%) in the incidence of the primary endpoint (a composite of death, recurrence of MI or readmission to hospital for unstable angina within 30 days of randomisation) compared to placebo. In the Lipid-Coronary Artery Disease (L-CAD) study, patients were randomised, 6 days after an acute MI and/or percutaneous transluminal coronary angioplasty (PTCA) secondary to unstable angina, to either pravastatin (combined, when necessary, with cholestyramine and/or nicotinic acid) to achieve low density lipoprotein cholesterol (LDL-C) levels of ≤130 mg/dl (n=70), or to antilipidaemic therapy determined by their family physicians (n=56). After 2 years, significantly fewer patients (odds ratio 0.28, p=0.005) in the pravastatin group experienced a clinical endpoint (total mortality, cardiovascular death, nonfatal MI, need for coronary intervention, stroke and new onset of peripheral arterial disease) compared to the control group. Furthermore, minimal lumen diameter assessed by quantitative coronary angioplasty decreased by 0.18 ± 0.28 mm in the pravastatin group, whereas it increased by 0.13 ± 0.29 mm in the control group, p<0.001). The LDL levels in the pravastatin and conEarly Statin Therapy in Patients with Acute Coronary Syndrome
Characterization of sodium alginate membrane crosslinked with glutaraldehyde in pervaporation separation (1998)

Dense sodium alginate (SA) membranes crosslinked with glutaraldehyde (GA) have been prepared by the solution method, wherein a nonsolvent of SA (acetone) was used in a reaction solution instead of an aqueous salt solution. Through infrared radation, X-ray diffractometry, and the swelling measurement, the crosslinking reaction between the hydroxyl groups of SA and the aldehyde groups of GA was characterized. To investigate the selective sorption behavior of the crosslinked SA membranes, swelling measurements of the membranes in ethanol-water mixtures of 70–90 wt % ethanol contents were conducted by equipment that was able to measure precisely the concentration and amount of the liquid absorbed in the membranes. It was observed that the crosslinking could reduce both the solubility of water in the resulting membrane and the permselectivity of the membrane toward water at the expense of membrane stability against water. The pervaporation separation of a ethanol-water mixture was conducted with the membranes prepared at different GA contents in the reaction solution. When the membrane was prepared at a higher GA content, both flux and separation factor to water were found to be reduced, thus resulting from the more crosslinking structure in it. The pervaporation separations of ethanol-water mixtures were also performed at different feed compositions and temperatures ranging from 40 to 80°C. A decline in the pervaporative performance was observed due to the relaxation of polymeric chains taking place during pervaporation, depending on operating temperature and feed composition. The relaxational phenomena were also elucidated through an analysis on experimental data of the membrane performance measured by repeating the operation in the given temperature range. © 1998 John Wiley & Sons, Inc. J Appl Polym Sci 67: 209–219, 1998
Micropower High-Detectivity Infrared Sensor System (1998)

In this paper we report a thermal infrared detector system for wireless integrated network sensors (WINS). This detector system includes a high sensitivity thin-film radiation thermopile and a micropower analog-to-digital converter (ADC) optimized for this unique system. The thermopile has an excellent responsivity of 100 V/W and a normalized detectivity of 1.lx10 9 cm*Hz 112 /W in vacuum. The ADC includes a chopper for low noise measurement of the low frequency infrared sensor output. The ADC provides greater than 9-bit resolution and DC stability at a micropower level of 30W.
Transition metal complexes of a functionalised triazamacrocycle (1992)

The imidazole- and pyrazole-functionalised macrocyclic ligands 1,4,7-tris(1-methylimidazol-2-ylmethyl)-1,4,7-triazacyclononane, L1, and 1,4,7-tris(pyrazol-1-ylmethyl)-1,4,7-triazacyclononane, L2, form stable complexes with some 3d metal cations of formula [ML]Y2(M = Fe, L = L1 or L2, Y = BPh4; M = Co, L = L1, Y = ClO4; L = L2, Y = BPh4; M = Ni, L = L1, Y = BPh4 or ClO4; L = L2, Y = BPh4; M = Cu, L = L1, Y = BPh4; L = L2, Y = ClO4; M = Zn, L = L2, Y = BPh4). The complexes have been isolated in the solid state and characterised by standard physicochemical methods. The complex [NiL2][BPh4]2 affords by slow recrystallisation from an acetonitrile—ethanol solution the new compound [Ni(CH3CN)L3][BPh4]2 where L3 is the new ligand 1,4-bis(pyrazol-1-ylmethyl)-1,4,7-triazacyclononane formed from L2 by a N-dealkylation reaction and loss of a pendant arm. Its crystal structure has been determined by X-ray diffraction: space group P21/c, a= 18.544(12), b= 12.460(5), c= 23.400(9)Å, β= 90.49(4)°; R 0.069 for 3025 observed reflections. The nickel atom is in a six-co-ordinate environment formed by the five nitrogen atoms provided by the L3 ligand and by the acetonitrile N atom. All Ni–N distances are in the range 2.00–2.11 Å, those formed by the macrocycle nitrogens spanning the upper half of this interval.
High data rate synchronizers operating at low speed (2002)

This paper presents a new technique which allows high baud rate with low operation speed of the synchronizer. This technique is based on parallel processing. What is done by only one clock operating at the baud rate can be done by two clocks operating only at half rate. By generalizing we propose versions of clock recovery circuits operating at the ratio 1/2/sup n/ of the data rate. Thus we obtain circuits transmitting at very high data rate but operating at very low frequency. The proposed circuits which are transition sensitive (digital) are compared with the traditional level sensitive (analog).
Effect of Insulin Treatment or Zinc Supplementation on Vitamin A Status in Streptozotocin-Induced Diabetic Rats. (1995)

A Using streptozotocin-induced diabetic rats, we examined the effects of zinc supplementation and insulin treatment on the metabolic availability of vitamin A. All diabetic animals exhibited an elevated plasma glucose (>18 mmol/liter) level within 48 h of intravenous streptozotocin injection. The untreated diabetic rats exhibited a reduction in body weight gain, with a 50% increase in daily food intake. In diabetic animals treated with insulin for 4 weeks, the plasma glucose, body weight gain, and daily food intake were comparable to those of the non-diabetic controls. The plasma concentration of vitamin A was significantly reduced in the diabetic animals, whereas the hepatic content of vitamin <b>A</b> in them was significantly elevated. Treatment with implantable insulin resulted in both plasma and liver concentrations of vitamin A returning to the control non-diabetic levels. Dietary zinc supplementation (120 µg/g diet for 4 weeks) failed to improve the plasma concentration of vitamin <b>A</b>. These results suggest that the impaired metabolic availability of vitamin A in the presence of diabetes is caused by insulin deficiency.
Fabrication and Characterization of FePt Exchange Coupled Composite and Graded Bit Patterned Media (2013)

Three methods to fabricate continuous FePt films with graded magnetic anisotropy for bit patterned media (BPM) were evaluated. Continuous FePt films with surface roughness of less than 0.3 nm were achieved in continuous FePt hard magnetic films, FePt/Fe exchange coupled composite (ECC) films and FePt/Fe based graded films. Depositing an Fe-rich film on FePt at high temperature was found to form large grains and cause the film surface very rough for BPM fabrication. Depositing Fe on FePt at room temperature and then annealing it to create graded anisotropy through the layer interdiffusion process was demonstrated to fabricate FePt/Fe based graded BPM. The continuous FePt films with hard layer only, ECC structure and graded magnetic anisotropy were patterned using a di-block copolymer self-assemble hard mask method with 25 nm dot size over 2-inch substrate. The switching field distribution (SFD) broadening and degradation of FePt BPM was studied. The reduction of SFD was achieved using a postannealing process. It was confirmed that the patterned graded BPM sample has smaller switching field and larger thermal energy barrier than the ECC sample.
Source-search sensitivity of a large-area, coded-aperture, gamma-ray imager (2005)

We have recently completed a large-area, coded-aperture, gamma-ray imager for use in searching for radiation sources. The instrument was constructed to verify that weak point sources can be detected at considerable distances if one uses imaging to overcome fluctuations in the natural background. The instrument uses a rank-19, one-dimensional coded aperture to cast shadow patterns onto a 0.57 m/sup 2/ NaI(Tl) detector composed of 57 individual cubes each 10 cm on a side. These are arranged in a 19 /spl times/ 3 array. The mask is composed of four-centimeter thick, one-meter high, 10-cm wide lead blocks. The instrument is mounted in the back of a small truck from which images are obtained as one drives through a region. Results of first measurements obtained with the system are presented.
Premonochromator for stray light rejection in Raman spectroscopy (1977)

A new apparatus for attenuating the Rayleigh light is described. The main components are two concave gratings mounted in a special nondispersive way. By means of the first grating the entrance slit of the apparatus is focused as an intermediate spectrum upon a sharp-edged movable mirror. This mirror reflects all the spectrum except the Rayleigh light to the second grating, which collects the light to an image of the entrance slit. The result is a sharp cutting of the spectrum at any desired position. The rejection of the Rayleigh line has been measured to less than 10(-5) (optimally 10(-6)). Raman lines can be.measured about 10 cm(-1) from the exciting line. The instrument has been used as a preeliminating unit coupled to a conventional double monochromator. It is expected that a system consisting of the instrument and a good single monochromator can be used for Raman studies.
Physical-layer cryptography through massive MIMO (2013)

We propose the new technique of physical-layer cryptography based on using a massive MIMO channel as a key between the sender and desired receiver, which need not be secret. The goal is for low-complexity encoding and decoding by the desired transmitter-receiver pair, whereas decoding by an eavesdropper is hard in terms of prohibitive complexity. The massive MIMO system has a channel gain matrix that is drawn i.i.d. according to a Gaussian distribution, subject to additive white Gaussian noise. The decoding complexity is analyzed by mapping the massive MIMO system to a lattice. We show that the eavesdropper's decoder for the MIMO system with M-PAM modulation is equivalent to solving standard lattice problems that are conjectured to be of exponential complexity for both classical and quantum computers. Hence, under the widely-held conjecture that standard lattice problems are of worst-case complexity, the proposed encryption scheme has security that exceeds that of the most common encryption methods used today such as RSA and Diffie-Hellman. Additionally, we show that this scheme could be used to securely communicate without a pre-shared secret key and little computational overhead. In particular, a standard parallel channel decomposition allows the desired transmitter-receiver pair to encode and decode transmissions over the MIMO channel based on the singular value decomposition of the channel, while decoding remains computationally hard for an eavesdropper with an independent channel gain matrix, even if it knows the channel gain matrix between the desired transmitter and receiver. Thus, the massive MIMO system provides for low-complexity encryption commensurate with the most sophisticated forms of application-layer encryption by exploiting the physical layer properties of the radio channel.
Cytochrome <i>P</i>450 enzymes: Novel options for cancer therapeutics (2004)

The concept of overexpression of individual forms of cytochrome P450 enzymes in tumor cells is now becoming well recognized. Indeed, a growing body of research highlights the overexpression of P450s, particularly CYP1B1, in tumor cells as representing novel targets for anticancer therapy. The purpose of this review is to outline the novel therapeutic options and opportunities arising from both enhanced endogenous expression of cytochrome P450 in tumors and cytochrome P450-mediated gene therapy.
Linked sensor data (2010)

A number of government, corporate, and academic organizations are collecting enormous amounts of data provided by environmental sensors. However, this data is too often locked within organizations and underutilized by the greater community. In this paper, we present a framework to make this sensor data openly accessible by publishing it on the Linked Open Data (LOD) Cloud. This is accomplished by converting raw sensor observations to RDF and linking with other datasets on LOD. With such a framework, organizations can make large amounts of sensor data openly accessible, thus allowing greater opportunity for utilization and analysis.
Acetylation of nascent polypeptide chains on rat liver polyribosomes in vivo and in vitro (1975)

Rat liver polyribosomes may be acetylated in vivo utilizing [3-H]acetate as precursor and in vitro with [14-C]acetyl-CoA. The in vitro acetylation occurs almost completely in the amino terminal position while the in vivo acetylation (after correction for isotopic exchange and incorporation of tritium into nonacetyl positions of amino acids) was distributed equally between the amino terminal groups of a number of amino acids and the epsilon-amino groups of internal lysine residues. At least 50% of the labeled acetyl groups introduced in vivo as well as in vitro could be removed from polysomes as puromycin polypeptides or -peptidyl-tRNA. The acetylated polypeptides have been resolved by gel filtration into two components, one with an average molecular weight of 20,000 and the other of 4000-7000. The results presented indicate that the N-terminal acetylation of nascent growing polypeptides is a post initiation event that occurs on small peptides (40-70 amino acid residues) and depends on the presence of a polysome-bound acetyltransferase which differs from other cytoplasmic acetyltransferases which catalyze predominately the acetylation of internal amino groups of proteins.
3D finite-difference modeling of elastic wave propagation in the Laplace-Fourier domain (2012)

ABSTRACT With the recent interest in the Laplace-Fourier domain full waveform inversion, we have developed new heterogeneous 3D fourth- and second-order staggered-grid finite-difference schemes for modeling seismic wave propagation in the Laplace-Fourier domain. Our approach is based on the integro-interpolation technique for the velocity-stress formulation in the Cartesian coordinate system. Five averaging elastic coefficients and three averaging densities are necessary to describe the heterogeneous medium, with harmonic averaging of the bulk and shear moduli, and arithmetic averaging of density. In the fourth-order approximation, we improved the accuracy of the scheme using a combination of integral identities for two elementary volumes — “small” and “large” around spatial gridpoints where the wave variables are defined. Two solution approaches are provided, both of which are solved with iterative Krylov methods. In the first approach, the stress variables are eliminated and a linear system for the velocity components is solved. In the second approach, we worked directly with the first-order system of velocity and stress variables. This reduced the computer memory required to store the complex matrix, along with reducing (by 30%) the number of arithmetic operations needed for the solution compared to the fourth-order scheme for velocity only. Numerical examples show that our finite-difference formulations for elastic wavefield simulations can achieve more accurate solutions with fewer grid points than those from previously published second and fourth-order frequency-domain schemes. We applied our simulator to the investigation of wavefields from the SEG/EAGE model in the Laplace-Fourier domain. The calculation is sensitive to the heterogeneity of the medium and capable of describing the structures of complex objects. Our technique can also be extended to 3D elastic modeling within the time domain.
Global Normalization (1970)

Abstract In Czechoslovakia the normalization is complete. Its communist party has not become a slaughterhouse, to use Husak's expression, but the treatment it has endured is no worse than the Polish party's decapitation of the '30's. The same is true of the labor union which had vainly sought to rediscover a consensus and a function during the new course in '68. The mass purges have eliminated all traces of grass roots reorganization of that society. The reawakening of two years ago is now seen as a collective drunken frenzy — the product of bad national character. The official newspapers now describe the Czechs as a people ill-fatedly lacking “the American's sense of business acumen, the depths of Russian thought, and German precision.”
Iron metabolism-new perspectives in view (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIron metabolism-new perspectives in viewRobert R. Crichton and Roberta J. WardCite this: Biochemistry 1992, 31, 46, 11255–11264Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/bi00161a001https://doi.org/10.1021/bi00161a001research-articleACS PublicationsRequest reuse permissionsArticle Views318Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ColorCAT: Guided Design of Colormaps for Combined Analysis Tasks (2015)

Colormap design is challenging because the encoding must match the requirements of data and analysis tasks as well as the perception of the target user. A number of well-known tools exist to support the design of colormaps. ColorBrewer [HB03], for example, is a great resource to select colors for qualitative, sequential, and diverging data. PRAVDAColor [BRT95] and Tominski et al. [TFS08], for example, provide valuable guidelines for single analysis tasks such as localization, identification, and comparison. However, for solving real world problems in most practical applications, single elementary analysis tasks are not sufficient but need to be combined. In this paper, we propose a methodology and tool to design colormaps for combined analysis tasks. We define color mapping requirements and develop a set of design guidelines. The visualization expert is integrated in the design process to incorporate his/her design requirements, which may depend on the application, culture, and aesthetics. Our ColorCAT tool guides novice and expert designers through the creation of colormaps and allows the exploration of the design space of color mapping for combined analysis tasks.
A Verifiable System for Automated Face Identification (2016)

In this paper, we consider a use case where an airport passenger travels and uses an automated gate to cross a border.We detail three phases: a pre-check before the arrival at the airport, the travel of the passenger from his check-in to the automated border gates and finally, the crossing of the gate. To accelerate the throughput at the border gates, we want to identify his face among a flight passenger list during the second phase. This identification is split between the passenger who takes a picture of his face with his smartphone and the immigration authorities. We rely on cryptographic verifiable computation techniques to ensure the security of the process. Experimental results show that our protocol is practical.
Effect of a mudcake on the propagation of stoneley waves in a borehole (2002)

The problem of detecting a permeable stratum blocked by a mudcake with the help of acoustic measurements inside a borehole is considered. Different physical models of the mudcake are compared: in the form of a highly viscous liquid layer, in the form of a soft elastic shell, and in the form of an elastic shell fixed in an arbitrary way to the borehole walls. Numerical calculations are presented for the wave field in a borehole.