gebhart/patrepeval huggingface dataset:
p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair (2009)

The p53 family activates many of the same genes in response to DNA damage. Because p63 and p73 have structural differences from p53 and play distinct biological functions in development and metastasis, it is likely that they activate a unique transcriptional network. Therefore, we performed a genome-wide analysis using cells lacking the p53 family members after treatment with DNA damage. We identified over 100 genes involved in multiple pathways that were uniquely regulated by p63 or p73, and not p53. Further validation indicated that BRCA2, Rad51, and mre11 are direct transcriptional targets of p63 and p73. Additionally, cells deficient for p63 and p73 are impaired in DNA repair and p63+/-;p73+/- mice develop mammary tumors suggesting a novel mechanism whereby p63 and p73 suppress tumorigenesis.
Phosphate adsorption reactions with clay minerals (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphate adsorption reactions with clay mineralsJames K. Edzwald, Donald C. Toensing, and Michael Chi-Yew. LeungCite this: Environ. Sci. Technol. 1976, 10, 5, 485–490Publication Date (Print):May 1, 1976Publication History Published online1 May 2002Published inissue 1 May 1976https://pubs.acs.org/doi/10.1021/es60116a001https://doi.org/10.1021/es60116a001research-articleACS PublicationsRequest reuse permissionsArticle Views1697Altmetric-Citations134LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nanoparticle-induced resonant tunneling behaviors in small molecule organic light-emitting devices (2009)

We report a hybrid nanoparticle/organic device with strong resonant tunneling behavior by introducing ligand-capped Ag nanoparticles between indium tin oxide and hole transport layer in small molecule organic light-emitting devices. The dependences of resonant tunneling current on the thickness of the organic layers are investigated. For the optimized device, a peak-to-valley current ratio as high as 4.5 and narrow peak width about 1.8 V are obtained. Combining with the analysis of current-voltage behavior, the mechanism based on the charge trapping effect of Ag nanoparticles is proposed to interpret the operation of the hybrid device. Finally, the emission characteristics of hybrid devices are also studied.
Die Rolle neuer Informations- und Kommunikationstechnologie für die Bürgerinformation (1996)

Dieser Artikel gibt einen Überblick über die Nutzung und Nutzungspotentiale von Informati-ons- und Kommunikationstechnologie für die Bürgerinformation. Zuerst wird der derzeitige Stand der Nutzung dargestellt. Dann werden einige innovative Anwendungen für die Bürger-information vorgestellt. Aus diesen Beispielen und weiteren Untersuchungen werden Einfluß-faktoren und ein zukünftiger Trend von Bürgerinformationssystemen in Deutschland abgelei-tet. Ein paar Gedanken zu Gelegenheiten für die Informationsindustrie schließen den Artikel.
The Intrusion Detection System design in WLAN based on rogue AP (2010)

Wireless IDS (Intrusion Detection System) can help network system quickly identify attacks, which extends the system administrator's security management capabilities (including security audits, monitoring, attack recognition and response), improves the integrity of the information security infrastructure. Wireless IDS will be an important part of the wireless LAN. Although it still has some flaws, but overall the superior than inferior. The scanning it can detect such as DoS attacks and other 802.11 attacks, coupled with a strong security policy, can basically meet the security needs of a wireless LAN.
High Pressure Liquid Chromatography Equipment--II (1974)

The requirements for the basic parts of liquid chromatographs are discussed briefly. These parts include: a solvent reservoir, pump, injection system, column, detector and recorder. A table listing the different models of the major suppliers is included. Photographs of the most popular models are shown. Major features of the different models are listed in the table.
Identité locale, culture familiale et systèmes de production (1989)

Communication écrite Mon propos est de comparer trois pôles industriels localisés dans une aire d’étude chevauchant deux régions administratives, Aquitaine et Limousin. Deux de ces pôles ont en commun de former des îlots plus industrialisés que la moyenne de leur région respective. Les actifs du secteur secondaire y dépassent sensiblement les chiffres de la population active agricole et ceux des services. Le troisième pôle est, pour sa part, hors du circuit de la production. Il constitue un e...
Health Monitoring for Coated Steel Belts in an Elevator System (2012)

This paper presents a method of health monitoring for coated steel belts in an elevator system by measuring the electrical resistance of the ropes embedded in the belt. A model on resistance change caused by fretting wear and stress fatigue has been established. Temperature and reciprocating cycles are also taken into consideration when determining the potential strength degradation of the belts. It is proved by experiments that the method could effectively estimate the health degradation of the most dangerous section as well as other ones along the whole belts.
Multiple molecular approaches yield no evidence for sex-determining genes in lake sturgeon (<i>Acipenser fulvescens</i>) (2008)

Common DNA-based sexing assays have been widely used for the conservation and management of mammals and birds. However, many fishes do not have genetic sex determination and in those that do, the plasticity of the genes involved means that species-specific assays are normally required. Such DNA-sexing markers would be especially valuable in lake sturgeon (Acipenser fulvescens) because of their sexual monomorphism, delayed sexual maturity, and conservation status. We tried to identify genetic differences between male and female lake sturgeon using several different molecular genetic methods, including randomly amplified polymorphic DNA, representational difference analyses, subtractive hybridization, and a candidate gene approach. Ultimately, a number of genes were identified but none was sex-specific. Although the ultimate mechanism of sex determination is yet unknown, it is possible that sex determination is environmental in lake sturgeon, especially since recent studies have also failed to identify sex determination genes in other sturgeon species.
Signal Events: Cell Signal Transduction and Its Inhibition in Cancer (2003)

Signal transduction refers to communication processes used by regulatory molecules to mediate the essential cell processes of growth, differentiation, and survival. Signal transduction elements interact through complex biochemically related networks. Aberrations in signal transduction elements can lead to increased proliferative potential, sustained angiogenesis, tissue invasion and metastasis, and apoptosis inhibition. Most human neoplasms have aberrant signal transduction elements. Several compounds that target aberrant signal transduction elements, such as those in the ErbB family of tyrosine kinase receptors and mammalian target of rapamycin, are in development. To date, commercially available signal-transduction-targeting compounds include trastuzumab, a monoclonal antibody against the ErbB-2 receptor for the treatment of metastatic breast cancer overexpressing the ErbB-2 (HER-2) receptor, and gefitinib, an inhibitor of the ErbB-1 receptor tyrosine kinase that recently received regulatory approval for the treatment of patients with non-small cell lung cancer. In contrast to traditional cytotoxic treatments, although signal transduction inhibitors are capable of inducing tumor regression, particularly in malignancies that are principally driven by specific target aberrations, preclinical and early clinical investigations suggest that their predominant beneficial effects are growth inhibitory in nature; therefore, new clinical trial designs and evaluation end points may be required to ultimately assess their value. Prospective profiling of patients and tumors to determine treatment response is also essential to the success of these clinical trials. However, responsiveness to these novel therapies is dependent on a multitude of factors that ultimately determine the robustness and quality of the downstream response.
Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins (1998)

We have developed a technique, fast retrieval of gel shift activities (FROGS), that allows for the rapid isolation of proteins that interact with DNA. Using this technique, we have isolated two proteins that are structurally similar to Mix.1, a PAX class homeodomain protein with ventralizing activity in Xenopus. The Mix family of proteins are expressed during late blastula and gastrula stages of Xenopus development. During gastrulation, these genes are expressed at high levels in distinct, yet overlapping regions in mesoderm and endoderm. The members of the Mix family heterodimerize with each other and overexpression of each results in severe axial abnormalities. Mix.3 and Mix.4 can directly induce primitive ectoderm to become endoderm whereas Mix.1 cannot. Injection of Mix.3 or Mix.4 RNA in the whole embryo results in extensive ectopic endodermin mRNA expression. The expression of the Mix family homeoproteins is differentially regulated by activin, Vg1, BMP-4, and fibroblast growth factor, supporting a model in which the Mix homeoproteins are downstream effectors of growth factor signaling during endoderm and ventral mesoderm formation.
Tri-reforming : A new process for reducing CO2 emissions (2001)

Penn State researchers have developed a new process for the conversion and use of carbon dioxide in flue gas from power plants. The tri-reforming process is a three step process that uses water, oxygen and CO{sub 2} in flue gas to tri-reform natural gas and produce synthesis gas (syngas). The article describes the process. The researchers have studied the proposed process in a fixed-bed flow reactor using gas mixtures at atmospheric pressure that simulate the cases with flue gases from coal and natural gas fired power plants. An important feature of the process is the conversion and utilization of CO{sub 2} without separating CO{sub 2}. 11 refs., 2 figs., 2 tabs.
Temperature dependence of domain-wall depinning fields in constricted Permalloy nanowires (2008)

We use ballistic Hall micromagnetometry to determine depinning fields of domain walls (DWs) in Permalloy nanowires in the temperature range between 5 and 50K. The walls are pinned in constrictions defined by a triangularly shaped notch on one side of the wire. The high sensitivity of the Hall sensor to local stray fields allows the detection of individual DWs and a distinction of different wall types. A strong temperature dependence of the depinning fields is observed that can be described by a model with a single energy barrier. For temperatures above 20K, additional types of DWs occur.
Sildenafil extends survival and graft function in a large animal lung transplantation model☆ (2006)

Sildenafil treatment prevents terminal early graft failure, allowing lung transplantation after 24-h ischemia time. Reperfusion edema was strikingly diminished, preserving pulmonary structural and functional integrity while prolonging graft ischemia time. Employing the established PDE-5 inhibitor sildenafil during lung perfusion, storage, and implantation, ischemic tolerance may be extended and early graft function improved.
Hadamard Coded Modulation for Visible Light Communications (2014)

Visible light communication (VLC) systems using the indoor lighting system to also provide downlink communications require high average optical powers in order to satisfy the illumination needs. This can cause high amplitude signals common in higher-order modulation schemes to be clipped by the peak power constraint of the light emitting diode (LED) and lead to high signal distortion. In this paper we introduce Hadamard coded modulation (HCM) to achieve low error probabilities in LED-based VLC systems needing high average optical powers. This technique uses a fast Walsh-Hadamard transform (FWHT) to modulate the data as an alternative modulation technique to orthogonal frequency division multiplexing (OFDM). HCM achieves a better performance for high illumination levels because of its small peak to average power ratio (PAPR). The power efficiency of HCM can be improved by reducing the DC part of the transmitted signals without losing any information. The resulting so-called DC-reduced HCM (DCR-HCM) is well suited to environments requiring dimmer lighting as it transmits signals with lower peak amplitudes compared to HCM, which are thus subject to less nonlinear distortion. Interleaving can be applied to HCM to make the resulting signals more resistant against inter-symbol interference (ISI) in dispersive VLC links.
Sensitivity of Optimal Linear Systems to Small Variations in Parameters† (1966)

ABSTRACT Optimal linear systems with quadratic performance indexes are analysed for sensitivity to small parameter variations. In particular, if the parameters can be separated in a certain way, it is shown that calculation of the sensitivity coefficients depends on the solution of sets of linear equations similar in form to the well-known Lyapunov matrix equation. An important example is when the elements of the matrices of the linear system are themselves regarded as the parameters. Expressions arc obtained for the sensitivity of the performance index, the optimal control law and the state vector.
Anterior Cruciate Ligament Graft Preparation: A New and Quick Alternative to the Whipstitch (2006)

Anterior cruciate ligament reconstruction is a common procedure in orthopaedic practice. Hamstring autograft is increasingly becoming the graft of choice; however, there is little consensus as to the best method of graft preparation and, in particular, the efficacy of the use of a whipstitch with all tibial fixation systems. We propose a new, quick, and economical method of preparing the hamstring graft that involves securing a double loop of suture material around the tendon. This is achieved by passing a loop of No. 2 braided suture under the tendon; the free suture ends are then subsequently passed through the loop twice and tightened. This "loop-the-loop" traction suture allows the surgeon to apply adequate traction to the graft for tensioning while not compromising graft fixation. This new technique is faster than conventional whipstitching and has cost savings, because no needles are necessary. It is of particular help when using a central 4-quadrant sleeve-and-screw fixation device.
A Dynamic Reservation Scheme based on Online Charging System with Family Shared Plan (2014)

For simplifying the bills and controlling the data usage, Family Shared Plan (FSP) is now a popular plan of telecommunications. Based on 3GPP specifications, Online Charging System (OCS) has to determine Granted Unit (GU) and create reservations per session before the services are delivered by the serving network. However, fixed GUs can not be adapted to dynamic consumer behaviors, such as travel, watching FIFA World Cup all night or taking pleasure in a new online application. Obviously, short of GUs will make redundant signals of reservation, but excessive ones will cause scarcity of resource. Since how to determine GU is an open issue by telecommunications operators, we design a new scheme to periodically assign dynamical GUs for subscribers belong to same FSP, based on their data usage and shared monthly data allowance. Simulation results not only show that our algorithm can substantially reduce redundant signals more than 3 times, no matter what unpredictable behaviors they do, but also observe interrelation between logging time and cooldown timer in our scheme.
Speech recognition using temporal decomposition and multi-layer feed-forward automata (2003)

A report is presented of intraspeaker and interspeaker variability as a major source of error in automatic speech recognition. The authors report on two series of experiments using multilayer feed-forward automata (MLFFA) to control some aspects of this variability. The first series concerns the classification of spectral targets obtained from a robust implementation of temporal decomposition. An MLFFA accepts three successive targets to output an allophonic label. No improvement has been found so far from traditional classification techniques (i.e. k-nearest neighbors). In a second series of experiments spectral transformations using MLFFA are introduced for the adaptation to new speakers. Compared to linear techniques (multivariate regression and canonical correlation analysis), the MLFFA approach offers some improvement.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hardware acceleration of logic simulation using a data flow microarchitecture (1985)

Current digital logic simulators running on engineering workstations lack capacity and speed. This paper discusses a hardware accelerator for a workstation simulator which addresses these problems. The accelerator runs 100x faster than its software counterpart and can simulate up to 1 million gates. The accelerator has been built and is being sold commercially. The architecture of the accelerator is similar to that of a classical dataflow machine. We describe the architecture of the machine and illustrate how it would simulate a simple circuit. We then briefly discuss the relationship between event driven simulation and dataflow.
Bidirectional Personalized Mobile Broadcasting System (2010)

To vitalize the terrestrial DMB market, we introduce a personalized DMB(PDMB) service model based on metadata, especially DMB ECG XML standardized by TTA, under the convergence of broadcasting and telecommunications. Also we introduce the personalized DMB service system developed to validate the conformance of DMB ECG XML standard and the usefulness of DMB ECG service. The personalized DMB service system is described in details from the authoring stage to the consumption stage of the contents. The results of experimental tests for the personalized DMB service system are also introduced in this paper. We finally address the possibility of making successful personalized DMB services in mobile multimedia broadcasting market.
An Integrative Way for Studying Neural Basis of Basic Emotions With fMRI (2019)

How emotions are represented in the nervous system is a crucial unsolved problem in the affective neuroscience. Many studies are striving to find the localization of basic emotions in the brain but failed. Thus, many psychologists suspect the specific neural loci for basic emotions, but instead, some proposed that there are specific neural structures for the core affects, such as arousal and hedonic value. The reason for this widespread difference might be that basic emotions used previously can be further divided into more "basic" emotions. Here we review brain imaging data and neuropsychological data, and try to address this question with an integrative model. In this model, we argue that basic emotions are not contrary to the dimensional studies of emotions (core affects). We propose that basic emotion should locate on the axis in the dimensions of emotion, and only represent one typical core affect (arousal or valence). Therefore, we propose four basic emotions: joy-on positive axis of hedonic dimension, sadness-on negative axis of hedonic dimension, fear, and anger-on the top of vertical dimensions. This new model about basic emotions and construction model of emotions is promising to improve and reformulate neurobiological models of basic emotions.
Microbial Impact on Arsenic Mobilization in Zloty Stok Gold Mine (2009)

The aim of this review report was to summarize knowledge about arsenic-metabolizing bacteria isolated from Zloty Stok (SW Poland) gold mine and determine their potential role in mobilization of arsenic. Three physiologically different groups of arsenic metabolizing microorganisms (arsenite oxidizers, dissmiliatory arsenate reducers and arsenic resistant microbes) were isolated from the deepest section of Gertruda Adit in Zloty Stok (SW Poland) gold mine. Twenty two strains were isolated from the rock biofilms and seven from arsenic-rich bottom sediments. Analysis of the 16S rRNA gene sequence of isolated bacteria revealed them to be members of the genera: Aeromonas, Arthrobacter, Bacillus, Brevundimonas, Chryseobacterium, Desemzia, Microbacterium, Micrococcus, Paracoccus, Pseudomonas, Rhodococcus, Serratia, Shewanella, Sinorhizobium, Sphingomonas, Stenotrophomonas and Streptomyces. All of the isolated bacteria were resistant to both inorganic arsenic species: arsenate [As(V)] and arsenite [As(III)]. One of the bottom sediments isolates (Sinorhizobium sp. M14) was able to grow on minimal salt medium using arsenite as a source of energy, and was able to release arsenic from arsenopyrite. Two strains (Shewanella sp. O23S and Aeromonas sp. O23A) isolated from bottom sediments were able to grow in the absence of oxygen, by As (V) respiration coupled with lactate oxidation. Based on arsenic metabolic activity of isolated bacteria two different mechanisms of arsenic mobilization from natural minerals (arsenopyrite FeAsS) and secondary ferrous arsenate minerals (scorodite FeAsO4) were proposed.
Surface characterization of fluorinated polyimide films grown by vapor deposition polymerization (1993)

Vapor deposition polymerization (VDP) was used to prepare fluorinated polyimide films. The process utilizes the coevaporation of 2,2-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride (6FDA) and 2,2′-bis(trifluoromethyl)-4,4′-diaminobiphenyl (TFDB) monomers. We characterized the surface by x-ray photoelectron spectroscopy (XPS), scanning electron microscopy, atomic force microscopy (AFM), and scanning tunneling microscopy (STM). The XPS analysis showed that the film stoichiometry greatly depended on the ratio of source effusion rates, and that a 6FDA/TFDB pressure ratio of 1:10 was best for obtaining stoichiometric 6FDA/TFDB polyimide. The surface structure image obtained by AFM was clearly different from that of spin-cast films. The surface morphology of the VDP films was characterized by an accumulation of parallel rod shaped structures, whereas that of the spin-cast one was a rough structure. The surface morphology of the VDP grown films at the initial growth state was also found to be a vertical stripe structure according to STM results.