gebhart/patrepeval huggingface dataset:
On a special action of the serum of highly immunised animals (1897)

By " like " sorts of serum and vibrios is meant that the immunisation has been carried on with diferent races of the same species of microbe.Thus cholera serum and cholera vibrios, or typhoid bacilli and typhoid serum, are each of " like " sort ; but cholera serum and typhoid bacilli, or typhoid serum and cholera vibrios, are of remote " u d i k e " sort.The serum obtained by fi particular race of microbes is called the " own" serum of that particular race,
Lysine Scanning of Arg<sub>10</sub>–Teixobactin: Deciphering the Role of Hydrophobic and Hydrophilic Residues (2016)

Teixobactin is a recently discovered antimicrobial cyclodepsipeptide with good activity against Gram positive bacteria. Taking Arg<sub>10</sub>-teixobactin as a reference, where the nonproteinogenic residue l-allo-enduracididine was substituted by arginine, a lysine scan was performed to identify the importance of keeping the balance between hydrophilic and hydrophobic amino acids for the antimicrobial activities of this peptide family. Thus, the substitution of four isoleucine residues present in the natural sequence by lysine led to a total loss of activity. On the other hand, the substitution of the polar noncharged residues and alanine by lysine allowed us to keep and in some cases to improve the antimicrobial activity.
Repetition-rate tunable micromechanical passivelymode-locked semiconductor laser (1996)

The authors present a novel, repetition-rate tunable, micromechanical passively mode-locked semiconductor laser, which consists of a multi-segment laser with a monolithic moving micro -mirror driven by an electrostatic comb structure. Continuous repetition-rate tunability by mirror displacement is demonstrated in 22.7 GHz fundamental mode-locking.
Dynamic Modeling of a Hybrid Switched-Capacitor-Based Converter with Phase-Shift Control (2018)

This paper is focused on modeling of dynamic responses in a hybrid switched-capacitor based dc-dc converter with a nominal 2:1 conversion ratio. Operating the converter well above resonance minimizes current stresses, and allows zero voltage switching and simple phase-shift control. A discrete-time small-signal model is developed, which accurately captures high frequency dynamics including effects of Lr-Cr resonance, and sampling associated with the phase-shift modulator. The model shows how the conversion ratio and the choice of the resonant frequency affect the location of high frequency zeros, which may be utilized to simplify control and compensation requirements, especially when operating well above resonance around the nominal 2:1 conversion ratio. The discrete-time model facilitates direct Z-domain compensator design using digital phase-shift control. Simulation and experimental results are provided to validate the model.
Effect of Transition Metal Addition on Liquid Phase Sintering of W–Cu (1994)

AbstractCobalt, iron, and nickel were added to copper in order to accelerate the liquid phase sintering process of W–Cu composite. The sintering behaviour of tungsten with additions of these elements varied widely depending on the addition element even though the rate of densification could be significantly enhanced by suitable additions of these elements. Additions inexcess of the amount necessary to form a continuous layer lead to successively decreasing sintering rates in the case of cobalt, while no decrease could be observed with increase in the quantity of added iron, and the sintering rate increased continuously with increasing nickel additions. The difference in the wettability of the tungsten surface by the liquid copper was attributed to the effects of additives on liquid phases intering of W–Cu compacts. PM/0639
SIP Embedded Attribute Certificates For Service Mobility in Heterogeneous Multi-Operator Wireless Networks (2007)

Next generation wireless networks will take advantage of the popularity and the data rates offered by unlicensed wireless networks such as WiFi ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Wireless</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Fidelity</i> ) or WiMAX ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Worldwide</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Interoperability</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">for</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Microwave</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Access</i> ) to enhance cellular services Le. UMTS (Universal Mobile Telecommunication System). Although currently exist approaches that provide service mobility, they rely on the assumption that cellular operators also own or manage the WiFi/WiMAX networks. Nevertheless, in spite of the business-related and technical differences of network operators/service providers we consider that service mobility between cellular and independent unlicensed wireless networks is feasible. In this article we present the SIP embedded Attribute Certificates to enable service mobility in heterogeneous multi- operator wireless networks.
Dimensions of linear polystyrene molecules in solution: Molecular weight dependence for low molecular weights (1957)

Abstract Intrinsic viscosities were measured for sharply fractionated polymer in a good solvent and in a poor solvent at several temperatures. They increased with specific volume of the solute, [η] = Φ L 3 / M . Φ was considered as an empirical constant depending on solute and solvent. Values were determined for polystyrene/toluene and polystyrene/cyclohexane, using light‐scattering measurements for derivation of molecular weights and dimensions. The equation was assumed valid for extrapolation to lower molecular weights and used to estimate molecular dimensions from viscosity/molecular weight data in a range not directly measurable. The results were compared with theoretical calculations of the random coil problem.
Improved response and survival to combined cisplatin and radiation in non-keratinizing squamous cell carcinomas of the head and neck. An RTOG study of 114 advanced stage tumors (1987)

Effective treatment modalities for Stage III and IV squamous cell carcinomas (SCC) of the head and neck are limited and seldom result in long term survival. The improved results with cisplatin containing chemotherapy have been encouraging and represent an additional therapeutic modality for head and neck cancer. To estimate the effectiveness of concomitant radiation and cisplatin chemotherapy, the Radiation Therapy Oncology Group (RTOG) initiated a Phase II study for patients with advanced nonresectable SCC of the head and neck. In addition, the diagnostic biopsy specimens were collected. Two pathologists reviewed and scored the biopsy specimens for a number of histologic parameters, including degree of keratinization, nuclear pleomorphism, frequency of mitoses, inflammatory and stromal reaction, pattern of invasion and vascular involvement in order to identify potential prognostically important patient subgroups. A total of 114 patients were evaluated for complete clinical responses (CR). These were achieved in 76% for all head and neck sites (ALL), and in 72% of the patients excluding nasopharyngeal and sinus cancers (REST). Evaluation of histopathologic parameters through multivariate analysis identified the presence of keratin as the most significant in predicting CR. Non-keratinizing SCC had CRs of 98% (ALL), and 94% (REST), as compared with 64% and 67% in the patients with keratin producing neoplasms (P less than 0.001 and 0.05) respectively. Survival at 24 months was found to be improved in the non-keratinizing SCC (P = 0.002). Multivariate analysis also identified the frequency of mitoses as being important in predicting for CR in patients with keratin in the biopsy findings. Biopsy specimens from ALL patients with two or more mitotic figures per high-power microscopic field had 76% CRs, in comparison with 46% when none or one mitotic figure was observed (P = 0.02). In the restricted group of patients (REST), the CR was 77% in the high mitotic figure group as opposed to 45% in the lower rate group (P = 0.03). However, this significant difference in CR rates did not translate into improved survival for the high CR subset.
Evaluation of PARP inhibition as a platinum sparing strategy in Brca2-deficient pancreatic tumors. (2014)

e15237 Background: BRCA1/2 mutations are found in up to 5% of patients with PAC. PARP inhibitors (PARPi) and platinum based chemotherapy may have increased anti-tumor efficacy in this population due to deficient DNA repair by homologous recombination (HR). We evaluated the use of cisplatin (CDDP) alone and in combination with the PARPi Olaparib (Ola) in a Brca2deficient murine model of PAC. Methods: KrasG12D/+; p53R270H/+; Pdx-1-Cre; Brca2mut mice were generated as previously described. Experimental mice began treatment at day 30 +/- 2 days with intraperitoneal (IP) CDDP 6mg/kg every 21 days with Ola 50mg/kg IP daily 5 days/week (n=11) or vehicle (n=11). A further 7 mice received Ola alone at same schedule and 8 mice received vehicle only. Pancreatic imaging was performed by T2 weighted MRI at regular intervals. For CDDP treated mice, treatment was held after dose #4 in the absence of visible pancreatic tumor on MRI for toxicity concerns and reinstated only at time of tumor growth. Mice were euthanized for weight loss >20% or failure to thrive/lethargy. Results: Median overall survival was significantly prolonged in CDDP treated mice compared to Ola alone or vehicle (p<0.001), with 48% continuing on treatment. The addition of Ola to CDDP increased time to pancreatic tumor identification and reduced the need for reintroduction of CDDP. Ola treatment compared to vehicle showed modest prolongation in survival and attenuation of tumor growth which did not reach statistical significance. Conclusions: DNA damaging chemotherapy has significantly greater efficacy than single agent PARPi in a HR repair deficient preclinical model of PAC, however the combination of CDDP with Ola prolongs time to primary tumor growth and time to retreatment with CDDP. A concurrent multicenter phase I/II clinical trial of gem/cisplatin +/- ABT-888 in patients with BRCA1/2mutation associated PAC led by MSKCC will prospectively evaluate the combination of CDDP and PARPi in a genetically selected repair deficient population. Treatment Median time to tumor on MRI (days) Median OS (days) CDDP & Olaparib 163 171 CDDP & vehicle 134 164 Olaparib 55 87 Vehicle 45 70
Literature Analysis on Model based Slicing (2013)

To understand and test a large software product is very challenging task. One way to ease this is program slicing technique that decomposes the large programs into smaller ones and another is model based slicing that decomposes the large software architecture model into smaller models at the early stage of SDLC (Software Development Life Cycle). This literature analysis presents an overview of Model based slicing, including the various general approaches and techniques used to compute slices.
Low-voltage polymer-based scanning cantilever for in vivo optical coherence tomography (2005)

Novel hand-held optical coherence tomography (OCT) probes with polymer cantilevers have been developed for clinical oral and skin imaging. An electroactive ionic polymer-metal composite cantilever was used to generate 3-mm transverse scanning movement of an optical fiber with applied 2-V linear alternating voltage at 1 Hz. Low driving voltage ensures safety. Two different optical designs achieve both forward and sidewise scanning and make it possible to image everywhere within the human oral cavity. In vivo OCT imaging of the human tongue is demonstrated.
Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast. (1990)

We have constructed eight restriction site polymorphisms in the DED81-ARG4 region and examined their behavior during meiotic recombination. Tetrad analysis reveals decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus, extending on one side into the ARG4 gene, and on the other side into the adjacent DED81 gene. Gene conversion events can extend in both directions from the initiation site as the result of a single meiotic event. There is a second gradient of gene conversion in DED81, with high levels near the 5' end of the gene and low levels near the middle of the gene. The peaks of gene conversion activity for the DED81 and ARG4 gradients map to regions where double-strand breaks are found during meiosis. The implications of these results for models of meiotic gene conversion are discussed.
Iterative reconstruction of SPECT data with adaptive regularization (2002)

A least-square reconstruction criterion is proposed for simultaneously estimating a SPECT (Single Photon Emission Computed Tomography) emission distribution corrected for attenuation together with its degree of regularization. Only a regularization trend has to be defined and tuned once for all on a reference study. Given this regularization trend, the precise regularization weight, which is usually fixed a priori, is automatically computed for each data set to adapt to the noise content of the data. We demonstrate that this adaptive process yields better results when the noise conditions change than when the regularization weight is kept constant. This adaptation is illustrated on simulated cardiac data for noise variations due to changes in the acquisition duration, in the background intensity and in the attenuation map.
Small reductions in forest cover weaken terrestrial‐aquatic linkages in headwater streams (2004)

Summary 1. We assessed the impacts of deforestation on the energy base of headwater food webs in seven headwater streams in the Upper Chattahoochee basin, GA, U.S.A where percentage forest in catchments ranged from 82 to 96%. We measured terrestrial organic matter standing crop and determined consumer (crayfish and insectivorous fish) dependence on terrestrial versus aquatic energy sources via gut content and stable isotope analyses. 2. Standing crop of coarse particulate organic matter (CPOM) declined with deforestation at large scales (i.e. catchment deforestation and riparian deforestation at the entire stream network scale). Terrestrial plant matter, the dominant component of crayfish guts, declined in crayfish guts with reductions in CPOM standing crop and with deforestation. 3. Crayfish and insectivorous fish δ 13 C showed enrichment trends with deforestation, indicating isotopic divergence from CPOM, the most 13 C‐depleted basal resource, with reductions in catchment and riparian forest cover. Crayfish δ 13 C also exhibited enrichment with decreased instream CPOM standing crop. 4. A concentration‐dependent mixing model was used to calculate the relative dependence of crayfish and fish on terrestrial versus aquatic basal resources. Results suggested that both allochthonous CPOM and autochthonous production were important basal resources. Consumer dependence on CPOM decreased with reductions in canopy cover. 5. Our data suggest the importance of forest cover to headwater food webs at multiple scales, and that relatively low levels of riparian deforestation along headwater streams can lead to reductions in stream food web dependence on terrestrial subsidies.
Introduction to Polymers of Ethylene (2010)

This chapter contains sections titled: Genesis of Polyethylene Basic Description of Polyethylene Types and Nomenclature of Polyethylenes Molecular Weight of Polyethylenes Transition Metal Catalysts for Ethylene Polymerization
VCP: A virtualization cloud platform for SDN intra-domain production network (2012)

Software Defined Networking (SDN) is considered as a promising method to re-construct the architecture of Internet. At present, the programs of network protocols are mixed together in SDN controller. However, in the production network, an isolated network environment with private resources is needed for each network protocol running on the same SDN controller. It is therefore necessary to design a practical virtualization cloud platform on the SDN network operating system (NOS). In this paper, we introduce a virtualization cloud platform for SDN production network. A prototype is implemented and two cases are performed to show the feasibility and the effectiveness of our proposed framework.
Dispersants (2003)

Abstract Dispersants are compounds that are used to maintain particles suspended in a liquid medium, either water or an organic solvent. They can prevent or delay flocculation of the particles by providing repulsive forces, counteracting the van der Waals attraction. This attraction occurs through electrostatic or steric stabilization or through a combination of these mechanisms, electrosteric stabilization. Unlike classical dispersants, which are usually random polymers, modern dispersants consist of an anchoring section, which adheres to the particle surface, and a soluble section, which builds a protective shell around the particle. They can have different architectures: AB dispersants, AB‐diblock polymers, ABA‐ or ABC‐triblock polymers, and comb polymers. Syntheses of such architectures are discussed. Dispersants have some similarity, but also some clear differences, with other materials, like surfactants, chelants, precipitation inhibitors, and flocculants. Dispersants have numerous applications. They are used, among others, in cooling and heating water applications, in geothermal fluids, seawater distillation and reverse osmosis, in oilfield and mineral processing, in cements, asphalt, caulks, sealants and roof coatings, in detergents and cleaners, and in paints and printing inks.
Thymic Regulation of Primate Fetal Ovarian-Adrenal Differentiation (1985)

We report that fetal thymectomy inhibits oogenesis and induces abnormal ovarian differentiation in rhesus monkeys. In utero thymectomy (n = 5) elevated plasma follicle-stimulating hormone (7.8 +/- 1.1 microgram/ml vs. 4.2 +/- 0.5 microgram/ml; P less than 0.05) and decreased plasma prolactin (24.5 +/- 3.3 ng/ml vs. 76.3 +/- 11.2 ng/ml; P less than 0.05) concentrations compared with intact controls (n = 12), but did not change plasma luteinizing hormone, estradiol, cortisol, dehydroepiandrosterone sulfate, or thymosin-alpha 1 concentrations. In utero thymectomy reduced the weight of neonatal ovaries and adrenal glands, but not hepatic, renal, splenic, or total body weights. After fetal thymectomy, newborn ovaries (n = 8) contained a reduced total number of germ cells (123,926 +/- 11,651 vs. 432,034 +/- 40,311; P less than 0.001). The percentages of individual germ cell types were similar between thymectomized and intact groups (n = 11) except for an increased percentage of preantral-antral follicles in the thymectomy group (P less than 0.01). Our results indicate that the primate fetal thymus regulates antenatal ovarian follicular development, perhaps by interactions between the nascent immunologic and pituitary-ovarian systems.
Growth delay studies in patients with multiple metastases. (1980)

Patients with multiple measurable metastases can be used as their own perfectly matched controls to study the effect of different treatments on their metastases. Response to treatment may be assessed by sequential measurement of the regression and regrowth of the metastases and by assessment of the growth delay produced by each treatment. Three patients are described who have been studied in this way to investigate the addition of misonidazole to radiation. The results suggest that it is possible to obtain quantitative data that will discriminate between relatively small doses of radiation and provide interesting clinical information on tumour response. The problems of the method and its possible applications are discussed.
Removable septum port for a mass spectrometer all-glass inlet system (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRemovable septum port for a mass spectrometer all-glass inlet systemWalter G. Dunn and John B. HooperCite this: Anal. Chem. 1973, 45, 1, 216Publication Date (Print):January 1, 1973Publication History Published online1 May 2002Published inissue 1 January 1973https://pubs.acs.org/doi/10.1021/ac60323a038https://doi.org/10.1021/ac60323a038research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biomechanical evaluation of wrist-driven flexor hinge orthosis in persons with spinal cord injury (2013)

The wrist-driven flexor hinge orthosis (WDFHO) is a device used to restore hand function in persons with tetraplegic spinal cord injury by furnishing three-point prehension. We assessed the effectiveness and biomechanical properties of the WDFHO in 24 persons with cervical 6 or 7 tetraplegia who have severely impaired hand function. This study introduces a mechanical operating model to assess the efficiency of the WDFHO. Experimental results showed that pinch force increased significantly (p < 0.001) after using the WDFHO and was found to positively correlate with the strength of wrist extensor muscles (r = 0.41, p < 0.001). However, when the strength of the wrist extensors acting on the WDFHO was greater, the reciprocal wrist and finger motion that generates three-point prehension was less effective (r = 0.79, p < 0.001). Reliable and valid biomechanical evaluation of the WDFHO could improve our understanding of its biomechanics.
Materials Mechanics - The Basis of Advanced Technology for Ageing Aircraft (2001)

Materials mechanics plays a significant role in assessing the damage status and handling of an ageing aircraft. This paper deals with determination and use of operational loads monitoring regarding fatigue life evaluation at specifically damage critical locations as well as the resulting consequences in fleet management. Regarding damage-tolerant design specifically aspects such as simulation of multi-site damage cracking and optimised design of repairs are discussed. Finally some recent techniques and results with regard to structure integrated sensing in the context of smart structures is presented. Werkstoffmechanik – Basis neuer Technologien für die Beurteilung alternder Flugzeuge Werkstoffmechanik spielt eine wesentliche Rolle im Zusammenhang mit der Beurteilung und Behandlung des Zustandes alternder Flugzeuge. In dem Beitrag wird die Erfassung von Betriebslasten in Bezug auf Lebensdauerabschätzungen von schadenskritischen Bauteilen wie auch das sich daraus ergebende Flottenmanagement angesprochen. Im Hinblick auf schadenstolerante Bauteilauslegung wird die Simulation von Mehrfachschädigungen (Multi-Site Damage) und die optimierte Auslegung von Reparaturen diskutiert. Abschließend werden einige neuzeitlichere Techniken und Ergebnisse im Zusammenhang mit strukturintegrierter Sensorik unter dem Kontext Smart Structures vorgestellt.