gebhart/patrepeval huggingface dataset:
Hydroxyl Radical-scavenging Effects of Spices and Scavengers from Brown Mustard (<i>Brassica nigra</i>) (1997)

The effects of methanol extracts of 51 spices on ·OH scavenging were studied in detail. 2-Deoxyribose oxidation and sodium benzoic acid hydroxylation methods were used for detecting the scavenging activity of ·OH. Mustard varieties, thyme, oregano, clove, and allspice all exhibited strong ·OH-scavenging activity. In particular, 3 varieties of mustard had above 90% ·OH-scavenging activity with a 1 μg/ml concentration of their extracts. The ·OH scavenger of Brassica nigra (brown mustard) was isolated and purified by XAD-2 column chromatography and preparative HPLC, and was identified as a 3,5-dimethoxy-4-hydroxycinnamic acid methyl ester by MS, 'H-NMR, and 13C-NMR. The 3,5-dimethoxy-4-hydroxycinnamic acid methyl ester was prepared by methylating of sinapic acid with diazomethane.
Plasma Deposition of Perylene–Adamantane Nanocomposite Thin Films for NO<sub>2</sub> Room-Temperature Optical Sensing (2012)

This work reports the preparation, by a new remote assisted plasma deposition process, of luminescent nanocomposite thin films consisting of an insoluble organic matrix where photonically active perylene molecules are embedded. The films are obtained by the remote plasma deposition of adamantane and perylene precursor molecules. The results show that the adamantane precursor is very effective to improve the perylene–adamantane nanocomposite transparency in comparison with plasma deposited perylene films. The plasma deposited adamantane films have been characterized by secondary-ion mass spectrometry and FT-IR spectroscopy. These techniques and atomic force microscopy (AFM) have been also used for the characterization of the nanocomposite films. Their optical properties (UV–vis absorption, fluorescence, and refractive index) have been also determined and their sensing properties toward NO2 studied. It is found that samples with the perylene molecules embedded within the transparent plasma deposited matrix are highly sensitive toward this gas and that the sensitivity of the films can be adjusted by modifying the aggregation state of the perylene molecules, as determined by the analysis of their fluorescence spectra. By monitoring the fluorescence emission of these films, it has been possible to detect a NO2 concentration as low as 0.5 ppm in air at room temperature. Because of their chemical stability and transparency in the UV region, the remote plasma deposited adamantane thin films have revealed as an optimum host matrix for the development of photonically active composites for sensing applications.
X-STROWL: A generalized extension of XACML for context-aware spatio-temporal RBAC model with OWL (2012)

The rapid growth of location-based applications, geographic or large scale information systems has resulted in the demand of strictly controlling data access that requires specifying and enforcing fine grained policies with the variety of context-aware spatial and temporal restrictions. Besides, the interoperable use of distributed and heterogeneous data such as data sharing, data integration or data exchanging between different organizations has caused the formation and development of access control mechanisms using XML for enforcing security rules and policies in accordance with the international standards. In this paper, we propose an extension of XACML called the X-STROWL model for a generalized context-aware role-based access control (RBAC) model with the support of spatio-temporal restrictions and in conformity with the NIST standard for RBAC. In doing this, the XACML architecture is augmented with new functions and data types. In addition, policies are reorganized to adopt with the NIST standard. Besides, a set of conditions aimed to a certain circumstance can be generalized into a context profile and specified in the access control policies. The model also integrates the OWL ontology for semantic reasoning on hierarchical roles to simplify the specification of access control policies and increase the intelligence of the authorization decision engine.
Pre-column electrochemical cell for high-performance liquid chromatography (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPre-column electrochemical cell for high-performance liquid chromatographyGary W. SchiefferCite this: Anal. Chem. 1979, 51, 9, 1573–1575Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/ac50045a050https://doi.org/10.1021/ac50045a050research-articleACS PublicationsRequest reuse permissionsArticle Views42Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Graded-base InGaN∕GaN heterojunction bipolar light-emitting transistors (2006)

The authors report radiative recombination from a graded-base InGaN∕GaN heterojunction bipolar transistor (HBT) grown by metal-organic chemical vapor deposition on sapphire. For a device with a 40×40μm2 emitter area, a differential dc current gain of 15 is measured from the common-emitter current-voltage characteristics, with the HBT breakdown voltage BVCEO&gt;65V. The heterojunction bipolar light-emitting transistor exhibits a base-region recombination radiation peak in the visible spectral range with a dominant peak at λ=385nm (blue emission).
Role of vascular potassium channels in the regulation of renal hemodynamics (2011)

K(+) conductance is a major determinant of membrane potential (V(m)) in vascular smooth muscle (VSMC) and endothelial cells (EC). The vascular tone is controlled by V(m) through the action of voltage-operated Ca(2+) channels (VOCC) in VSMC. Increased K(+) conductance leads to hyperpolarization and vasodilation, while inactivation of K(+) channels causes depolarization and vasoconstriction. K(+) channels in EC indirectly participate in the control of vascular tone by several mechanisms, e.g., release of nitric oxide and endothelium-derived hyperpolarizing factor. In the kidney, a change in the activity of one or more classes of K(+) channels will lead to a change in hemodynamic resistance and therefore of renal blood flow and glomerular filtration pressure. Through these effects, the activity of renal vascular K(+) channels influences renal salt and water excretion, fluid homeostasis, and ultimately blood pressure. Four main classes of K(+) channels [calcium activated (K(Ca)), inward rectifier (K(ir)), voltage activated (K(V)), and ATP sensitive (K(ATP))] are found in the renal vasculature. Several in vitro experiments have suggested a role for individual classes of K(+) channels in the regulation of renal vascular function. Results from in vivo experiments are sparse. We discuss the role of the different classes of renal vascular K(+) channels and their possible role in the integrated function of the renal microvasculature. Since several pathological conditions, among them hypertension, are associated with alterations in K(+) channel function, the role of renal vascular K(+) channels in the control of salt and water excretion deserves attention.
A Unified Architecture For Automatic Software Updates. (2004)

This paper attempts to address the issue of hardening the internal security of an organisation’s network by easing its patch management. Traditionally security has been modeled on a &quot;hard outer shell &quot; approach, with a firewall protecting the otherwise vulnerable internal network. With the advent of worms using such techniques as social engineering to bypass the organisational firewall and installing trojans, this approach is no longer sufficient. As a result of these new attacks, emphasis should be placed on improving the security of the internal network. Most research agrees that prompt patching of security vulnerabilities would significantly reduce the vulnerability of these machines. However, this requires system administrators not only to keep abreast of the flood of patches, but to ensure they are deployed to every machine, in what could be a very large network. These difficulties are worsened by problems the patches themselves often create. This is a difficult task and the failure of system administrators to perform it is echoed in the recent spate of worm attacks, with some taking advantage of vulnerabilities for which patches had been released up to six months earlier. To cope in this environment an organisation needs a comprehensive patch management policy. A technology agnostic view of this policy is described in order to better understand what is required of an automated solution. A few vendors have released tools to find vulnerabilities, find patches and distribute
Carboxylic acids in the hindgut of rats fed highly soluble inulin and Bifidobacterium lactis (Bb-12), Lactobacillus salivarius (UCC500) or Lactobacillus rhamnosus (GG) (2007)

Background: Propionic and butyric acids are important nutrients for the mucosal cells and may therefore increase the nutritional status and reduce the permeability of the colonic mucosa. These acids have also been suggested to counteract diseases in the colon, e.g. ulcerative colitis and colon cancer. Different substrates lead to different amounts and patterns of carboxylic acids (CAs). Objective: To study the effect of probiotics on CA formation in the hindgut of rats given inulin. Design: The rats were given inulin, marketed as highly soluble by the producer, together with the probiotic bacteria Bifidobacterium lactis (Bb-12), Lactobacillus salivarius (UCC500) or Lactobacillus rhamnosus (GG), or a mixture of all three. Results: Rats fed inulin only had comparatively high proportions of propionic and butyric acids throughout the hindgut. When diets were supplemented with Bb-12 and UCC500, the caecal pool of CAs increased compared with inulin only. In the caecum the proportion of butyric acid generally decreased when the rats were fed probiotics. In the distal colon the proportion of propionic and butyric acid was lower, while that of lactic acid was generally higher. The caecal pH in rats fed GG and Bb-12 was lower than expected from the concentration of CAs. Further, rats fed GG had the lowest weight gain and highest caecal tissue weight. Conclusions: It is possible to modify the formation of CAs by combining inulin with probiotics. Different probiotics had different effects. Keywords: Bifidobacterium lactis (Bb-12); carboxylic acids; inulin; Lactobacillus rhamnosus (GG); Lactobacillus salivarius (UCC500); prebiotics
Career resilience and its influencing factors among nurse specialists (2015)

Objective
To investigate the career resilience and its influencing factors among nurse specialists.


Methods
Totally 288 nurse specialists were investigated by General Information Questionnaire, Career Resilience Scale, Core Self-Evaluations Scale and Simplified Coping Style Scale.


Results
The score was 37.12±4.78 for career resilience, 35.46±4.78 for core self-evaluations, 23.57±5.21 for positive coping, and 9.39±3.74 for negative coping, respectively. There were statistic difference (P<0.01) among the total score and 2 dimensions score of career resilience on different level of self-assessment of health among specialist nurses.Specialist nurses, career resilience had a obvious positive correlation with the age, nursing age, core self-evaluations, and positive coping(P<0.01). The results of multivariate linear regression analysis showed that age, self-assessment of health, positive coping and core self-evaluations entered the regression equation of career resilience. Positive coping was a partial intermediate variable of core self-evaluations and career resilience.


Conclusion
The level of career resilience is medium and it should be enhanced among nurse specialists. The age, self-assessment of health, positive coping and core self-evaluations are possible influencing factors of career resilience. And core self-evaluations can improve career resilience of specialist nurses via the effects of positive coping.


Key words: 
Nurse specialists; Career resilience; Influencing factors; Cross-sectional study
[Apoptosis of B lymphocytic leukemia induced by anticancer drugs and their cell cycle specificity]. (1998)

Hypodiploid DNA-FCM and TdT assay + DNA staining can be used to detect both tumor cell apoptosis and their cell cycle specificity which is helpful to predict prognosis and to design new chemotherapy regimen.
Lenalidomide Plus High-Dose Dexamethasone Provides Improved Overall Survival Compared to High-Dose Dexamethasone Alone for Relapsed or Refractory Multiple Myeloma (MM): Results of 2 Phase III Studies (MM-009, MM-010) and Subgroup Analysis of Patients with Impaired Renal Function. (2006)

Abstract Lenalidomide is a novel, orally administered immunomodulatory drug (IMiD) that has single-agent activity against multiple myeloma (MM) and additive effects when combined with dexamethasone. We have previously reported improved response (OR), time to progression (TTP) and overall survival (OS) with lenalidomide-dexamethasone (Len-Dex) compared to dexamethasone-placebo (Dex) based on the results of 2 phase III trials (MM-009, North American, 353 pts; MM-010, Europe, Australia, and Israel, 351 pts). In both trials patients with relapsed or refractory MM not resistant to dexamethasone, were treated with dexamethasone 40 mg daily on days 1–4, 9–12, and 17–20 every 28 days and were randomized to receive either lenalidomide 25 mg daily orally on days 1–21 every 28 days or placebo. Beginning at cycle 5, Dex was reduced to 40 mg daily on days 1–4 only, every 28 days. Patients were also stratified with respect to B2M (≤2.5 vs. > 2.5 mg/mL), prior stem cell transplant (none vs. ≥ 1), and number of prior regimens (1 vs > 1). At a median follow-up from randomization of 17.1 mos (MM-009) and 16.5 mos (MM-010), both studies continue to show significant improvement with Len-Dex compared to Dex in OR (MM-009: 61% vs 20.5%, p<.001; MM-010: 59.1% vs. 24%, p<.001, respectively), TTP (MM-009: 11.1mos vs. 4.7mos, p<.001; MM-010: 11.3mos vs. 4.7mos, p<.001, respectively), and OS (MM-009: 29.6mos vs. 20.5mos, p<.001; MM-010: not estimable vs 20.6mos, p<.001, respectively). Pooled data from both trials demonstrates a significant improvement in duration of response for pts achieving ≥ PR with 122/216 pts (56.5%) who received Len-Dex continuing in remission (med. duration of response not reached but > 68.1 wks) compared to only 22/76 pts (28.9%) treated with dexamethasone alone (med. duration of response 22.1 wks, p<.001). An additional subgroup analysis was performed on pts with impaired creatinine clearance (cr cl). No significant difference in response rate, TTP, or OS was noted for patients with cr cl above or below 50 ml/min who were treated with Len-Dex, but for 16 pts with cr cl <30ml/min, med. TTP and OS was shorter than for those with cr cl >30ml/min, but still significantly higher than for pts treated with Dex. Grade 3–4 thrombocytopenia was significantly higher in pts with impaired renal function (<50ml/min, 13.8%; >50ml/min 4.6%, p<.01; <30ml/min, 18.8%, >30 ml/min, 5.5%, p<.05), but there was no difference for G3–4 neutropenia at either cutoff. Phase I–II evaluation to establish appropriate dosing in pts with cr cl < 30ml/min, particularly with respect to thrombocytopenia is warranted, but should not underscore improved OR, TTP, and OS for pts treated with Len-Dex regardless of creatinine clearance.
Antifouling performance for polyvinylidene fluoride membrane modified by plasma treatment in a MBR (2014)

Polyvinylidene fluoride(PVDF)hollow fiber ultrafiltration membrane was modified by acrylic acid(AA)plasma chemical sedimentary.The experiments of Fourier attenuated total reflection infrared spectroscopy(FT-IR),scanning electron microscopy(SEM),EDS and mechanical properties test analysis showed that after modified,there were some carboxyl in the membrane surface,and AA monomer was grafted successfully.Meanwhile,the flexibility of modified membrane was improved,and water flux increased by 12.04%~16.12%.Using submerged MBR reactor,gas-water ratio with 20∶1,the modified membrane and the original membrane were made parallel contrast experiment.The results show that the change of surface properties of membrane can hinder sedimentary and compacting of cake layer pollutants effectively on the membrane surface.After hydraulic and chemical cleaning,the flux recovery rate of modified membrane flux recovery rate is slightly higher than the original film,so the ability of resistance cake layer pollutants modified membrane is stronger than original membrane.The effluent turbidity of membrane and original membrane were 0NTU,and the COD removal rate showed that the water effect of modified membrane was better than the original membrane.
Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure–function studies and nucleoside biosynthesis (2009)

The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in the last 40 years, with this limited number falling into only four new structural classes. Several nucleoside natural product antibiotics target bacterial translocase MraY, involved in the lipid-linked cycle of peptidoglycan biosynthesis, and fungal chitin synthase. Biosynthetic studies on the nikkomycin, caprazamycin and pacidamycin/mureidomycin families are also reviewed.
Clinical significance of insulin-like growth factor-binding protein-3 expression in stage I non-small cell lung cancer. (2002)

The activities of insulin-like growth factors (IGFs), including mitogenic and antiapoptotic properties, are modulated by a family of high-affinity insulin-like growth factor-binding proteins (IGFBPs), of which IGFBP-3 is the major serum carrier protein. Even though it is well known that IGFBP-3 plays an important role in cell proliferation, the expression of IGFBP-3 and its significance in primary non-small cell lung cancer (NSCLC) samples are unknown. This study explored IGFBP-3 expression in tumor samples from 74 patients with a diagnosis of pathological stage I NSCLC to determine if the expression status of IFGBP-3 influences the prognosis of patients with NSCLC. Two-sided statistical analyses were performed to correlate the clinical parameters and the prognostic effect with the IGFBP-3 expression level in this cohort. Reduced IGFBP-3 expression was found in 42 (56.8%) of 74 samples, and it was more frequent in large cell carcinoma than in squamous cell carcinoma and adenocarcinoma, although this difference was not statistically significant. This phenomenon was not associated with the other clinicopathological parameters tested, such as age, sex, histological grade, and smoking history. Significant statistical correlation between IGFBP-3 expression and disease-specific survival was noted (P = 0.019 by log-rank test). Although statistically nonsignificant, patients with decreased IGFBP-3 expression had shorter overall, disease-free, and event-free survival rates than did patients with normal IGFBP-3 expression. In a multivariate analysis using IGFBP-3 expression and other clinicopathological parameters, the level of IGFBP-3 expression remained as an independent factor for predicting a shorter disease-specific survival probability (P = 0.020). Our work demonstrates that down-regulation of IGFBP-3 is a frequent event in stage I NSCLC and correlates with the disease-specific survival probability of patients with stage I NSCLC. These results suggest that IGFBP-3 functions as a tumor suppressor and plays an important role in determining biological aggressiveness in early NSCLC.
Chemoenzymatic Synthesis and Lectin Binding Properties of Dendritic <i>N</i>-Acetyllactosamine (1997)

Proof that multivalency amplifies individual carbohydrate-protein interactions is growing. N-Acetylglucosamine (GlcNAc)-based dendrimers with valencies of two (9), four (10), and eight (11) were prepared in fair to excellent yields (65-99%) on the basis of the rational scaffolding of L-lysine on solid phase using established Fmoc and HOBt chemistry. These GlcNAc dendrimers were then further transformed enzymatically (79-90% yields) into dendritic N-acetyllactosamine (LacNAc) derivatives [di-(12), tetra-(13), and octavalent (14)] using UDPglucose, UDP-glucose 4'-epimerase, and GlcNAc beta-1,4-galactosyltransferase. GlcNAc and LacNAc dendrimers were used to inhibit lectin-porcine stomach mucin interactions. Wheat germ agglutinin and Erythrina cristagalli lectin were used for GlcNAc and LacNAc dendrimers, respectively. Di-, tetra-, and octavalent GlcNAc dendrimers exhibited IC50S of 3100, 509, and 88 microM (6200, 2040, and 703 microM, with respect to monomeric GlcNAc content). IC50s for the LacNAc series were 341, 143, and 86 microM (682, 574, and 692 microM, as compared with monomeric LacNAc content). These data represent more than 20-fold increases in inhibitory potential for dendritic GlcNAc as compared to that for monomeric GlcNAc. Studies with E. cristagalli do not reveal significant increased inhibitory potential with multivalency.
Aminobenzole, VIII. Die Umlagerung von Carbamidsäure‐phenylestern — Synthesen von 2.4‐Dioxo‐3.4‐dihydro‐2<i>H</i>‐1.3‐benzoxazinen und Salicylamiden (1972)

Abstract Das thermische Verhalten der aus Phenolen und Isocyanaten dargestellten Carbamidsäureester (Urethane) 1a – x wird untersucht. N ‐Phenyl‐ und N ‐Benzoyl‐carbamidsäure‐phenylester lagern sich beim Erhitzen in N ‐substituierte Salicylamide 3 um. Die experimentellen Befunde machen einen intramolekularen Verlauf für diese der Fries ‐Umlagerung von Phenylestern vergleichbare Reaktion wenig wahrscheinlich. Bei der Thermolyse von N ‐Alkoxycarbonyl‐carbamidsäure‐phenylestern entstehen Benzoxazinone 6 , die sich mit verd. Kalilauge unter CO 2 ‐Abspaltung nahezu quantitativ in die Salicylamide 7 überführen lassen.
An NP-cluster based approach to coreference resolution (2004)

Traditionally, coreference resolution is done by mining the reference relationships between NP pairs. However, an individual NP usually lacks adequate description information of its referred entity. In this paper, we propose a supervised learning-based approach which does coreference resolution by exploring the relationships between NPs and coreferential clusters. Compared with individual NPs, coreferential clusters could provide richer information of the entities for better rules learning and reference determination. The evaluation done on MEDLINE data set shows that our approach outperforms the baseline NP-NP based approach in both recall and precision.