gebhart/patrepeval huggingface dataset:
Loss of Ribosomal Protein L11 Affects Zebrafish Embryonic Development through a p53-Dependent Apoptotic Response (2009)

Ribosome is responsible for protein synthesis in all organisms and ribosomal proteins (RPs) play important roles in the formation of a functional ribosome. L11 was recently shown to regulate p53 activity through a direct binding with MDM2 and abrogating the MDM2-induced p53 degradation in response to ribosomal stress. However, the studies were performed in cell lines and the significance of this tumor suppressor function of L11 has yet to be explored in animal models. To investigate the effects of the deletion of L11 and its physiological relevance to p53 activity, we knocked down the rpl11 gene in zebrafish and analyzed the p53 response. Contrary to the cell line-based results, our data indicate that an L11 deficiency in a model organism activates the p53 pathway. The L11-deficient embryos (morphants) displayed developmental abnormalities primarily in the brain, leading to embryonic lethality within 6-7 days post fertilization. Extensive apoptosis was observed in the head region of the morphants, thus correlating the morphological defects with apparent cell death. A decrease in total abundance of genes involved in neural patterning of the brain was observed in the morphants, suggesting a reduction in neural progenitor cells. Upregulation of the genes involved in the p53 pathway were observed in the morphants. Simultaneous knockdown of the p53 gene rescued the developmental defects and apoptosis in the morphants. These results suggest that ribosomal dysfunction due to the loss of L11 activates a p53-dependent checkpoint response to prevent improper embryonic development.
Characterization of a Neuregulin-Related Gene, <i>Don-1</i>, That Is Highly Expressed in Restricted Regions of the Cerebellum and Hippocampus (1997)

Members of the epidermal growth factor family of receptors have long been implicated in the pathogenesis of various tumors, and more recently, apparent roles in the developing heart and nervous system have been described. Numerous ligands that activate these receptors have been isolated. We report here on the cloning and initial characterization of a second ligand for the erbB family of receptors. This factor, which we have termed Don-1 (divergent of neuregulin 1), has structural similarity with the neuregulins. We have isolated four splice variants, two each from human and mouse, and have shown that they are capable of inducing tyrosine phosphorylation of erbB3, erbB4, and erbB2. In contrast to those of neuregulin, high levels of expression of Don-1 are restricted to the cerebellum and dentate gyrus in the adult brain and to fetal tissues.
Hot‐Pressing Behavior of Si <sub>3</sub> N <sub>4</sub> (1974)

The densification behavior of Si 3 N 4 containing MgO was studied in detail. It was concluded that MgO forms a liquid phase (most likely a magnesium silicate). This liquid wets and allows atomic transfer of Si 3 N 4 . Evidence of a second‐phase material between the Si 3 N 4 grains was obtained through etching studies. Transformation of α‐ to β‐Si 3 N 4 during hot‐pressing is not necessary for densification.
The time dimension of neural network models (1994)

This review attempts to provide an insightful perspective on the role of time within neural network models and the use of neural networks for problems involving time. The most commonly used neural network models are defined and explained giving mention to important technical issues but avoiding great detail. The relationship between recurrent and feedforward networks is emphasised, along with the distinctions in their practical and theoretical abilities. Some practical examples are discussed to illustrate the major issues concerning the application of neural networks to data with various types of temporal structure, and finally some highlights of current research on the more difficult types of problems are presented.
Complex roles of the stroma in the intrinsic resistance to gemcitabine in pancreatic cancer: where we are and where we are going (2017)

Pancreatic ductal adenocarcinoma (PDAC) is among the most devastating human malignancies. The poor clinical outcome in PDAC is partly attributed to a growth-permissive tumor microenvironment. In the PDAC microenvironment, the stroma is characterized by the development of extensive fibrosis, with stromal components outnumbering pancreatic cancer cells. Each of the components within the stroma has a distinct role in conferring chemoresistance to PDAC, and intrinsic chemoresistance has further worsened this pessimistic prognosis. The nucleoside analog gemcitabine (GEM) is usually the recommended first-line chemotherapeutic agent for PDAC patients and is given alone or in combination with other agents. The mechanisms of intrinsic resistance to GEM are an active area of ongoing research. This review highlights the important role the complex structure of stroma in PDAC plays in the intrinsic resistance to GEM and discusses whether antistroma therapy improves the efficacy of GEM. The addition of antistroma therapy combined with GEM is expected to be a novel therapeutic strategy with significant survival benefits for PDAC patients.
Fisher vector encoded deep convolutional features for unconstrained face verification (2016)

We present a method to combine the Fisher vector representation and the Deep Convolutional Neural Network (DCNN) features to generate a rerpesentation, called the Fisher vector encoded DCNN (FV-DCNN) features, for unconstrained face verification. One of the key features of our method is that spatial and appearance information are simultaneously processed when learning the Gaussian mixture model to encode the DCNN features. Evaluations on two challenging verification datasets show that the proposed FV-DCNN method is able to capture the salient local features and also performs well when compared to many state-of-the-art face verification methods.
Automatic extrinsic calibration of multiple laser range sensors with little overlap (2015)

Networks of laser range finders are a popular tool for monitoring large cluttered areas and to track people. Whenever multiple scanners are used for this purpose, one major problem is how to determine the relative positions of all the scanners. In this paper, we present a novel approach to calibrate a network of multiple planar laser range finders scanning horizontally. To robustly deal with the potentially restricted overlap between the fields of view, our approach only requires a dynamic object, e.g., a person, moving through the observed area. We employ a RANSAC-like algorithm to find the correspondences between the measurements of the different laser range finders. Based on these correspondences we formulate a graph-based optimization problem to determine the maximum likelihood extrinsic parameters of the sensor network. Furthermore, we present a method to evaluate the consistency of the resulting calibration based on visibility constraints. Experiments on real and simulated data show that the proposed approach yields better results than techniques that only perform pairwise calibration.
A modularization approach for linear-shaped functional supercapacitors (2016)

A self-standing PPy-based tube common module is obtained by using a reciprocal formwork construction technique. This common module can be further assembled with other building blocks to fabricate high performance linear-shaped supercapacitors.
Tracking the translational and rotational movement of the ball using high-speed camera movies (2005)

Skills to spin the ball are important for athletes in many sports such as baseball, soccer and tennis. Recently, researchers in aerodynamics and sports science started to analyze the correlation of the rotation and the trajectory of the ball; high speed cameras are used to analyze the rotation of the ball. However, the analysis had to be done either manually, or under special lighting condition. In this paper, we propose a new algorithm to track the translation and rotation of the ball shot by high speed cameras under outdoor ambient light condition. Using our system, the athletes can analyze their skills by shooting their motion and the resultant rotation of the ball. It can also be used as a tool to enhance sports TV programs by providing further scientific information to the audience.
Cell Motility Factors (1991)

Molecular analysis of amoeboid Chemotaxis: Parallel observations in amoeboid phagocytes and metastatic tumor cells.- Adhesion systems in embryonic epithelial-to-mesenchyme transformations and in cancer invasion and metastasis.- Neutrophil chemotactic factors.- Purification and characterization of scatter factor.- Purification, characterization and mechanism of action of scatter factor from human placenta.- Scatter factor stimulates migration of vascular endothelium and capillary-like tube formation.- The cellular response to factors which induce motility in mammahan cells.- The role of E-cadherin and scatter factor in tumor invasion and cell motility.- Heterogeneity amongst fibroblasts in the production of migration stimulating factor (MSF): Implications for cancer pathogenesis.- Cell motility, a principal requirement for metastasis.- Tumor cell autocrine motility factor receptor.- Interleukin-6 enhances motility of breast carcinoma cells.- Interleukin-6 stimulates motility of vascular endothelium.- Computer automation in measurement and analysis of cell motility in vitro.
Predicting Personal Life Events from Streaming Social Content (2018)

Researchers have shown that it is possible to identify reported instances of personal life events from users' social content, e.g., tweets. This is known as personal life event detection. In this paper, we take a step forward and explore the possibility of predicting users' next personal life event based solely on the their historically reported personal life events, a task which we refer to as personal life event prediction. We present a framework for modeling streaming social content for the purpose of personal life event prediction and describe how various instantiations of the framework can be developed to build a life event prediction model. In our extensive experiments, we find that (i) historical personal life events of a user have strong predictive power for determining the user's future life event; (ii) the consideration of sequence in historically reported personal life events shows inferior performance compared to models that do not consider sequence, and (iii) the number of historical life events and the length of the past time intervals that are taken into account for making life event predictions can impact prediction performance whereby more recent life events show more relevance for the prediction of future life events.
Anaphylactic Reaction s to Ig A: A Difficult Transfusion Problem (1970)

Journal Article Anaphylactic Reaction s to Ig A: A Difficult Transfusion Problem Get access William V. Miller, M.D., William V. Miller, M.D. Blood Bank Department, Clinical Center, National Institutes of Health, and Surgery Branch, National Cancer Institute, and Immunophysiology Section Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic Google Scholar Paul V. Holland, M.D., Paul V. Holland, M.D. Blood Bank Department, Clinical Center, National Institutes of Health, and Surgery Branch, National Cancer Institute, and Immunophysiology Section Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic Google Scholar Everett Sugarbaker, M.D., Everett Sugarbaker, M.D. Blood Bank Department, Clinical Center, National Institutes of Health, and Surgery Branch, National Cancer Institute, and Immunophysiology Section Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic Google Scholar Warren Strober, M.D., Warren Strober, M.D. Blood Bank Department, Clinical Center, National Institutes of Health, and Surgery Branch, National Cancer Institute, and Immunophysiology Section Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic Google Scholar Thomas A. Waldmann, M.D. Thomas A. Waldmann, M.D. Blood Bank Department, Clinical Center, National Institutes of Health, and Surgery Branch, National Cancer Institute, and Immunophysiology Section Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 54, Issue 4, 1 October 1970, Pages 618–621, https://doi.org/10.1093/ajcp/54.4.618 Published: 01 October 1970 Article history Received: 18 November 1969 Accepted: 22 January 1970 Published: 01 October 1970
Pressure-Induced Matrix Metalloproteinase-9 Contributes to Early Hypertensive Remodeling (2004)

MMP-9 seems to play a key role in the early stages of hypertensive vascular remodeling.
Metalloporphyrin-modified semiconductors for solar fuel production (2016)

We report a direct one-step method to chemically graft metalloporphyrins to a visible-light-absorbing gallium phosphide semiconductor with the aim of constructing an integrated photocathode for light activating chemical transformations that include capturing, converting, and storing solar energy as fuels. Structural characterization of the hybrid assemblies is achieved using surface-sensitive spectroscopic methods, and functional performance for photoinduced hydrogen production is demonstrated <i>via</i> three-electrode electrochemical testing combined with photoproduct analysis using gas chromatography. Measurements of the total per geometric area porphyrin surface loadings using a cobalt-porphyrin based assembly indicate a turnover frequency ≥3.9 H<sub>2</sub> molecules per site per second, representing the highest reported to date for a molecular-catalyst-modified semiconductor photoelectrode operating at the H<sup>+</sup>/H<sub>2</sub> equilibrium potential under 1-sun illumination.
Clustered multiattribute hash files (1989)

Access methods for multidimensional data have attracted much research interest in recent years. In general, the data structures proposed for this problem partition the database into a set of disk pages (buckets). Access to the buckets is provided by searching a directory of some type such as a tree directory or inverted index or by computation of a multiattribute hash function. Examples of the first approach are Multidimensional B-trees[Sch82], K-D-B trees[Rob81] (see also [Sam84] for a survey of these methods) whereas multiattribute hashing methods are described for example in [Rot74],[Aho79],[Riv76] and [Ram83]. In addition, there are also hybrid methods which combine hashing with a directory of some type [Ore84],[Nie84], [Fag79].
Audio output enhancement algorithms for piezoelectric loudspeakers (2011)

Piezoelectric loudspeakers have a small form factor and are suitable for electronic devices that have a thin profile. However, they have poor frequency response, especially in low frequencies. This paper introduces a method that combines psychoacoustic bass extension and sub-band dynamic range compression to make the audio sound “richer” in piezoelectric speakers. Subjective test results are also presented.
Mesoporous Silica Nanoparticles for Active Corrosion Protection (2011)

This work presents the synthesis of monodisperse, mesoporous silica nanoparticles and their application as nanocontainers loaded with corrosion inhibitor (1H-benzotriazole (BTA)) and embedded in hybrid SiOx/ZrOx sol-gel coating for the corrosion protection of aluminum alloy. The developed porous system of mechanically stable silica nanoparticles exhibits high surface area (∼1000 m2·g(-1)), narrow pore size distribution (d∼3 nm), and large pore volume (∼1 mL·g(-1)). As a result, a sufficiently high uptake and storage of the corrosion inhibitor in the mesoporous nanocontainers was achieved. The successful embedding and homogeneous distribution of the BTA-loaded monodisperse silica nanocontainers in the passive anticorrosive SiOx/ZrOx film improve the wet corrosion resistance of the aluminum alloy AA2024 in 0.1 M sodium chloride solution. The enhanced corrosion protection of this newly developed active system in comparison to the passive sol-gel coating was observed during a simulated corrosion process by the scanning vibrating electrode technique (SVET). These results, as well as the controlled pH-dependent release of BTA from the mesoporous silica nanocontainers without additional polyelectrolyte shell, suggest an inhibitor release triggered by the corrosion process leading to a self-healing effect.
The Promise and Challenges of Digital Oilfield Solutions—Lessons Learned From Global Implementations and Future Directions (2009)

Abstract Digital Oil Field (DOF) in the oil and gas industry has gained momentum in the last few years and has transformed from being a vision to projects that have measurable value. The promise of DOF has motivated many oil and gas operators and service companies to now establish corporate initiatives and associated business programs to develop and deploy DOF solutions. Many major capital projects are already evaluating the feasibility of DOF in early stages of the project decision process as part of the operational philosophy. However, the implementation of these projects over the last few years has unraveled a multitude of practical challenges and hurdles to achieve the DOF goals, including selecting the candidate of highest value opportunities in the business unit's portfolio, justifying a business case, establishing new management processes to address operational transformation, defining people roles and responsibilities in DOF work processes, forming a team of skilled personnel for development and support of installed solutions, recognizing fit-for-purpose models, identifying appropriate technologies for the rapid deployment of integrated workflows, lack of open architecture and standards, project management approach, and change management, among others. This paper describes the challenges faced in DOF implementations by Halliburton and the current industry status. The case studies presented highlight these issues and practical lessons learned about addressing these issues using novel solutions and delivering value through adopting best practices. The paper also provides an insight into future trends and areas of development, addressing areas of challenges that still must be resolved.
<i>f</i>-Finger Morra (1965)

Previous article Next article f-Finger MorraR. A. GoodR. A. Goodhttps://doi.org/10.1137/1007008PDFBibTexSections ToolsAdd to favoritesExport CitationTrack CitationsEmail SectionsAbout[1] Melvin Dresher, Games of strategy: Theory and applications, Prentice-Hall Applied Mathematics Series, Prentice-Hall Inc., Englewood Cliffs, N.J., 1961xii+186 MR0122586 (22:13310) 0096.14701 Google Scholar[2] A. W. Tucker and , H. W. Kuhn, Theory of Games, Encyclopaedia Brittanica, Vol. 10, 1956, editions since Google Scholar[3] J. D. Williams, The compleat strategyst, being a primer on the theory of games of strategy, McGraw-Hill Book Co., Inc., New York, 1954xiii+234 MR0061352 (15,812e) 0057.35203 Google Scholar Previous article Next article FiguresRelatedReferencesCited byDetails The Uncertainty Principle of Game Theory31 January 2018 | The American Mathematical Monthly, Vol. 114, No. 8 Cross Ref Volume 7, Issue 1| 1965SIAM Review History Submitted:10 October 1963Published online:01 August 2006 InformationCopyright © 1965 © Society for Industrial and Applied MathematicsPDF Download Article & Publication DataArticle DOI:10.1137/1007008Article page range:pp. 81-87ISSN (print):0036-1445ISSN (online):1095-7200Publisher:Society for Industrial and Applied Mathematics
Multi-faceted insight through interoperable visual information analysis paradigms (2002)

To gain insight and understanding of complex information collections, users must be able to visualize and explore many facets of the information. The paper presents several novel visual methods from an information analyst's perspective. The authors present a sample scenario, using the various methods to gain a variety of insights from a large information collection. They conclude that no single paradigm or visual method is sufficient for many analytical tasks. Often a suite of integrated methods offers a better analytic environment in today's emerging culture of information overload and rapidly changing issues. They also conclude that the interactions among these visual paradigms are equally as important as, if not more important than, the paradigms themselves.
The proposal of wireless multimedia communication system with integration of packet-switched and circuit-switched channels (2002)

We propose a novel wireless multimedia communication system. It provides a new data communication service by integrating packet-switched and circuit-switched channels. Future wireless multimedia systems must treat data communication calls efficiently to achieve high radio resource utilization. In the proposed system, a data communication user first establishes a packet-switched link to a remote server which is connected to a LAN, or an ISP (Internet Service Provider). Once a packet-switched link is established, the user is always offered real-time e-mail service or push services from the Internet over the packet-switched channel. When there is more information to be transferred than can be handled by the packet-switched channel, a circuit-switched link is established that replaces the packet-switched link to realize high speed data transmission. This replacement is performed automatically. Once the data transfer is completed, the circuit-switched link falls back to the packet-switched link. Thus, radio resource utilization is increased because the circuit-switched link is established only when really needed. This paper describes the proposed system concept, system configuration and system capacity as estimated by computer simulations. The results show that the proposed system improves system capacity by about 7% compared to conventional systems. Moreover, the blocking probability of data communication calls can be strongly reduced compared to conventional systems.
Creating hypermedia materials for English literature students (1987)

article Free Access Share on Creating hypermedia materials for English literature students Authors: Nicole Yankelovich Brown University Brown UniversityView Profile , George P. Landow Brown University Brown UniversityView Profile , David Cody Brown University Brown UniversityView Profile Authors Info & Claims ACM SIGCUE OutlookVolume 19Issue 3-4Spring/Summer 1987 pp 12–25https://doi.org/10.1145/964080.964084Published:01 April 1987Publication History 11citation217DownloadsMetricsTotal Citations11Total Downloads217Last 12 Months11Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF