gebhart/patrepeval huggingface dataset:
Design of a digital LED driver with auto-identifying open strings (2012)

In this paper, a novel digital control topology for high bright LEDs is proposed. And this driver can identify the open strings in LEDs array automatically to increase the reliability of the LEDs. There are two stages in this topology. The front stage is a PFC circuit controlled by the chip MC33262, and the DC/DC stage is a half bridge circuit controlled by the micro-controller. The output current of the controller is adjusted according to the number of the strings in the open-circuit state, so the current of a single LED ring can keep a constant value even when the number of working LED strings is changed. In the paper, the design process of the system is presented, an 112W prototype is presented in the laboratory, and the experimental results verify the control method proposed in the paper.
Real-time panorama composition for video surveillance using GPU (2016)

Image stitching algorithms combine multiple low resolution images and provide a single high resolution composite image with a larger field of view available for video surveillance. In this research work, we put forward and realize real-time panorama composition for a video surveillance application using the power of a GPU. We utilize a cross platform OpenGL graphics library for real-time online image processing. We parallelize panorama composition using OpenGL objects such as texture object, vertex buffer object and framebuffer object for image warping as well as edge blending to create a seamless panoramic image. We divide our panorama composition algorithm into two stages for image sources with fixed relative positions with each other. Initially in an offline stage, we compute inverse lookup maps and feather weight masks using an OpenCV image processing library for each input image. Subsequently in an online stage, we utilize these inverse lookup maps to generate warped images, which are further edge blended with each other using feather weight masks with the help of OpenGL objects. Our panorama composition is more than 8.5 times faster than the CUDA optimized OpenCV realization. It produces a high resolution seamless panoramic image using nine input image streams each with 800×600 image resolution at about more than 75 frames per second using less than 90MB of GPU memory.
Self-Calibration for the Multiple Channel Phase Array System Based on Near-Field Weighting (2015)

Traditional in-field self-calibration techniques for some multiple channel systems, whose volume and weights are limited, are inefficient. A more simple calibration technique, employing only one assistant source in near-field and one transceiver channel, is investigated and it's unnecessary to conduct complex feed circuits behind the antennas. Furthermore, the calibration method in the principle of minimum channel errors with the near-field weighting (NFW) is proposed. It's a method in channel level for the compensation of errors between sub-arrays based on the proved fact that the channel errors have a stronger impact on the beam pattern than the random element errors. The channel errors could be obtained just by one time of measurement. A series of analysis and simulated results demonstrate that the proposed method is efficient in practice.
A Review on the Pharmacology and Toxicology of Steviol Glycosides Extracted from Stevia rebaudiana (2016)

Stevia rebaudiana Bertoni is a sweet and nutrient-rich plant belonging to the Asteraceae family. Stevia leaves contain steviol glycosides including stevioside, rebaudioside (A to F), steviolbioside, and isosteviol, which are responsible for the plant's sweet taste, and have commercial value all over the world as a sugar substitute in foods, beverages and medicines. Among the various steviol glycosides, stevioside, rebaudioside A and rebaudioside C are the major metabolites and these compounds are on average 250-300 times sweeter than sucrose. Steviol is the final product of Stevia metabolism. The metabolized components essentially leave the body and there is no accumulation. Beyond their value as sweeteners, Stevia and its glycosdies possess therapeutic effects against several diseases such as cancer, diabetes mellitus, hypertension, inflammation, cystic fibrosis, obesity and tooth decay. Studies have shown that steviol glycosides found in Stevia are not teratogenic, mutagenic or carcinogenic and cause no acute and subacute toxicity. The present review provides a summary on the biological and pharmacological properties of steviol glycosides that might be relevant for the treatment of human diseases.
Binocular coordination of saccades at far and at near in children and in adults (2003)

The goal of the study was to test the quality of binocular coordination of saccades in children and adults, and its dependency upon the viewing distance. Fourteen normal children (4.5-12 years old) and 10 normal adults (22-44 years old) participated. Two distances were studied: far (150 cm) and close (20 cm). Horizontal saccades from both eyes were recorded simultaneously by a photoelectric device. The results show (i) poor binocular coordination of saccades in children is distance dependent: coordination is particularly poor at near and could compromise single binocular vision; and (ii) post-saccadic drift analysis indicates that stability of the eyes after the saccade as well as the quality of binocular alignment during fixation are poor in children, regardless of the viewing distance. The results provide a reference for the normal development of binocular motor control and have important implications for reading in young children.
Surface plasmon resonance analysis of the mechanism of binding of apoA-I to high density lipoprotein particles (2009)

The partitioning of apolipoprotein A-I (apoA-I) molecules in plasma between HDL-bound and -unbound states is an integral part of HDL metabolism. We used the surface plasmon resonance (SPR) technique to monitor in real time the reversible binding of apoA-I to HDL. Biotinylated human HDL(2) and HDL(3) were immobilized on a streptavidin-coated SPR sensor chip, and apoA-I solutions at different concentrations were flowed across the surface. The wild-type (WT) human and mouse apoA-I/HDL interaction involves a two-step process; apoA-I initially binds to HDL with fast association and dissociation rates, followed by a step exhibiting slower kinetics. The isolated N-terminal helix bundle domains of human and mouse apoA-I also exhibit a two-step binding process, consistent with the second slower step involving opening of the helix bundle domain. The results of fluorescence experiments with pyrene-labeled apoA-I are consistent with the N-terminal helix bundle domain interacting with proteins resident on the HDL particle surface. Dissociation constants (K(d)) measured for WT human apoA-I interactions with HDL(2) and HDL(3) are about 10 microM, indicating that the binding is low affinity. This K(d) value does not apply to all of the apoA-I molecules on the HDL particle but only to a relatively small, labile pool.
Machine Learning-Based Fast Intra Mode Decision for HEVC Screen Content Coding via Decision Trees (2019)

The screen content coding (SCC) extension of high efficiency video coding (HEVC) improves coding gain for screen content videos by introducing two new coding modes, namely, intra block copy (IBC) and palette (PLT) modes. However, the coding gain is achieved at the increased cost of computational complexity. In this paper, we propose a decision tree-based framework for fast intra mode decision by investigating various features in the training sets. To avoid the exhaustive mode searching process, a sequential arrangement of decision trees is proposed to check each mode separately by inserting a classifier before checking a mode. As compared with the previous approaches where both IBC and PLT modes are checked for screen content blocks (SCBs), the proposed coding framework is more flexible which facilitates either the IBC or PLT mode to be checked for SCBs such that computational complexity is further reduced. To enhance the accuracy of decision trees, dynamic features are introduced, which reveal the unique intermediate coding information of a coding unit (CU). Then, if all the modes are decided to be skipped for a CU at the last depth level, at least one possible mode is assigned by a CU-type decision tree. Furthermore, a decision tree constraint technique is developed to reduce the rate-distortion performance loss. Compared with the HEVC-SCC reference software SCM-8.3, the proposed algorithm reduces computational complexity by 47.62% on average with a negligible Bjøntegaard delta bitrate (BDBR) increase of 1.42% under all-intra (AI) configurations, which outperforms all the state-of-the-art algorithms in the literature.
Gaze+Gesture (2015)

Humans rely on eye gaze and hand manipulations extensively in their everyday activities. Most often, users gaze at an object to perceive it and then use their hands to manipulate it. We propose applying a multimodal, gaze plus free-space gesture approach to enable rapid, precise and expressive touch-free interactions. We show the input methods are highly complementary, mitigating issues of imprecision and limited expressivity in gaze-alone systems, and issues of targeting speed in gesture-alone systems. We extend an existing interaction taxonomy that naturally divides the gaze+gesture interaction space, which we then populate with a series of example interaction techniques to illustrate the character and utility of each method. We contextualize these interaction techniques in three example scenarios. In our user study, we pit our approach against five contemporary approaches; results show that gaze+gesture can outperform systems using gaze or gesture alone, and in general, approach the performance of "gold standard" input systems, such as the mouse and trackpad.
Fungal Transformations as a Useful Method for the Synthesis of Organic Compounds (1983)

Click to increase image sizeClick to decrease image sizeKey Words: fungal transformationsorganic synthesisβ-lactamssteroidsalkaloidsflavonoidsenzymes
Serological Evaluation of Specific-Antibody Levels in Patients Treated for Chronic Chagas' Disease (2007)

Serological tests are the main laboratory procedures used for diagnosis during the indeterminate and chronic stages of Chagas' disease. A serological regression to negativity is the main criterion used to define parasitological cure in treated patients. The aim of this work was to monitor the individual specificities of antibody levels for 3 years posttreatment in 18 adult patients. Conventional serological techniques (hemagglutination assays and enzyme-linked immunosorbent assay [ELISA]) were modified by using recombinant antigens to detect early markers of treatment effectiveness. For this purpose, serum samples were taken before and during treatment and every 6 months after treatment for at least 3 years. When hemagglutination assays were used, a decrease in antibody levels was observed in only one patient. When ELISA with serum dilutions was used, antibody clearance became much more apparent: in 77.7% (14/18) of the patients, antibody titers became negative with time. This was observed at serum dilutions of 1/320 and occurred between the 6th and the 30th months posttreatment. The immune response and the interval for a serological regression to negativity were different for each patient. For some of the recombinant antigens, only 50% (9/18) of the patients reached the serological regression to negativity. Recombinant antigen 13 might be a good marker of treatment effectiveness, since 66.6% (six of nine) of the patients presented with an early regression to negativity for specific antibodies to this antigen (P = 0.002).
Discrete and integral fourier transforms: analytical examples. (1993)

Analytical examples of the discrete Fourier transform (DFT) help in understanding relations between the DFT and the Fourier integral transform (FIT). Such examples enable one to estimate the errors involved when one transform is approximated by the other, and they suggest how such approximation errors might be reduced. We present mathematical and numerical analyses of the time-to-frequency DFT of the complex exponential function and of the frequency-to-time inverse DFT of the relaxation function. The FITs of these functions are exact inverses, and so they serve to clarify the effects of aliasing and truncation on the DFT.
Web II: web-based simulation of systems described by partial differential equations (2001)

This paper describes how to take advantage of Internet services and object technology to solve 2D partial differential equations (PDEs) in a distributed manner. This is accomplished by means of a distributed object oriented continuous simulation language designed by our research group, called OOCSMP, and a Java (and C++) generating compiler for this language (called C-OOL). We also describe a graphical mesh generator, which produces OOCSMP code. The mesh generator may be invoked from the simulation model allowing the generation of domains and meshes during model execution. The simulation of the heating of several moving pieces is shown, in the single machine case, and in the distributed case.
C-Nitroso Compounds: Synthesis, Physicochemical Properties and Biological Activities (2005)

Because of the chemical and physical properties of nitric oxide, its effective use and delivery for therapeutic application represents a significant challenge. Accordingly, current understanding of nitric oxide biology largely stems from the use of nitric oxide prodrugs and adducts whose biological activities are based on their ability to release nitric oxide or a redox-related species. Among the structurally diverse ensemble of nitric oxide donor compounds reported to date are the C-nitroso compounds. These compounds have only recently been investigated with respect to their potential as nitric oxide donors, although they have been known and studied for over 120 years. Here, we consider the synthesis and physico-chemical properties of the C-nitroso compounds and the available data regarding their biological activities. Synthetic methods reviewed include direct substitution of H by NO, oxidative approaches, and the addition of various oxides of nitrogen across multiple bonds. The electronic spectra of C-nitroso compounds and the mechanism and thermodynamics of monomer-dimer equilibration are described. The physico-chemical and biological properties of two related classes of compounds, the diazetine dioxides and the furoxans, are also described.
Application of machine learning methods to histone methylation ChIP-Seq data reveals H4R3me2 globally represses gene expression (2010)

In stark contrast to univariate analysis of the relationship between H4R3me2 and gene expression levels, our study showed that the regulatory role of some modifications like H4R3me2 is masked by confounding variables, but can be elucidated by multivariate/systems-level approaches.
A<i>Candida albicans</i>Petite Mutant Strain with Uncoupled Oxidative Phosphorylation Overexpresses<i>MDR1</i>and Has Diminished Susceptibility to Fluconazole and Voriconazole (2007)

We showed that a Candida albicans petite mutant in which oxidative phosphorylation is uncoupled was eightfold more resistant to fluconazole and voriconazole than SC5314 but equally susceptible to ketoconazole, itraconazole, and amphotericin B. Strain P5 significantly overexpressed MDR1, which likely accounts for the decreased drug susceptibility.
Expression of Cytokine, Chemokine, and Adhesion Molecules during Endothelial Cell Activation Induced by Antibodies against Dengue Virus Nonstructural Protein 1 (2005)

Vascular dysfunction is a hallmark associated with disease onset in dengue hemorrhagic fever and dengue shock syndrome. In addition to direct viral damage, immune responses to dengue virus (DV) infection may also underlie the pathogenesis of disease. We have proposed a mechanism of molecular mimicry in which Abs directed against DV nonstructural protein 1 (NS1) cross-react with endothelial cells and induce damage. In this study, we demonstrated the inflammatory endothelial cell activation induced by anti-DV NS1 via the transcription factor NF-kappaB-regulated pathway. Protein phosphorylation and NF-kappaB activation were observed after anti-DV NS1 stimulation in a human microvascular endothelial cell line-1. The cytokine and chemokine production, including IL-6, IL-8, and MCP-1, but not RANTES, in endothelial cells increased after treatment with anti-DV NS1 Abs. The expression of IL-6, IL-8, and MCP-1 was blocked by the preabsorption of anti-DV NS1 with DV NS1 or by the inhibition of NF-kappaB activation. Furthermore, the increases in both ICAM-1 expression and the ability of human PBMC to adhere to endothelial cells were also observed, and these effects were inhibited by pretreatment with anti-ICAM-1 or anti-MCP-1 Abs. Therefore, in addition to endothelial cell apoptosis, as previously reported, inflammatory activation occurs in endothelial cells after stimulation by anti-DV NS1 Abs. These results suggest the involvement of anti-DV NS1 Abs in the vasculopathy of DV infection.
Interference aware Bluetooth packet scheduling (2002)

Bluetooth is a radio technology for wireless personal area networks operating in the 2.4 GHz ISM band. Since both Bluetooth and IEEE 802.11 devices use the same frequency band and may likely come together in a laptop or may be close together at a desktop, interference may lead to significant performance degradation. The main goal of this paper is to propose a scheduling algorithm aimed at reducing the impact of interference. This algorithm takes advantage of the fact that devices in the same piconet will not be subject to the same levels of interference on all channels of the band. The basic idea is to utilize the Bluetooth frequency hopping pattern and distribute channels to devices in order to maximize their throughput while ensuring fairness of access among users. Simulation results are given for selected scenarios and configurations of interest.
Schema-Independent and Schema-Friendly Scientific Metadata Management (2008)

Computational science is creating a deluge of data, and the automated capture and cataloging of detailed descriptive metadata has been recognized as necessary to enable reuse of this data. Scientific communities in varied disciplines have developed detailed XML metadata schemas to describe data products. Our research has identified characteristics of scientific schemas that can be exploited to efficiently capture and search this metadata based on the schemas specific to each community, but using an easily adaptable framework.
Acquisition of neuronal and glial markers by neural crest–derived cells in the mouse intestine (2002)

Enteric neurons and glia arise from the neural crest. The phenotype of crest-derived cells was examined as they differentiated into neurons or glia in the mouse small and large intestine. Previous studies have shown that undifferentiated enteric crest-derived cells are Phox2b(+)/Ret(+)/p75(+)/Sox10(+), and at embryonic day (E) 10.5, about 10-15% of the crest-derived cells in the small intestine have started to differentiate into neurons. In the current study, by E12.5 and E14.5, about 25% and 47%, respectively, of Phox2b(+) cells in the small intestine were immunoreactive to the pan-neuronal protein, ubitquitin hydrolase (PGP9.5), and the percentage did not change dramatically from E14.5 onward. The differentiation of crest-derived cells into neurons in the colon lagged behind that in the small intestine by several days. Differentiating enteric neurons showed high Ret, low p75, and undetectable Sox10 immunostaining. Glial precursors were identified by the presence of brain-specific fatty acid binding protein (B-FABP) and detected first in the fore- and rostral midgut at E11.5. Glial precursors appeared to be B-FABP(+)/Sox10(+)/p75(+) but showed low Ret immunostaining. S100b was not detected until E14.5. Adult glial cells were B-FABP(+)/Sox10(+)/p75(+)/S100b(+). A nucleic acid stain (to identify all ganglion cells) was combined with immunostaining for PGP9.5 and S100b to detect neurons and glial cells, respectively, in the postnatal intestine. At postnatal day 0, fewer than 5% and 10% of cells in myenteric ganglia of the small and large intestine, respectively, were neither PGP9.5(+) nor S100b(+). Because some classes of neurons are not present in significant numbers until after birth, the expression of PGP9.5 by developing enteric neurons appeared to precede the expression of neuron type-specific markers.
Quadrupolar π‐Gels: Sol–Gel Tunable Red–Green–Blue Emission in Donor–Acceptor‐Type Oligo(<i>p</i>‐phenylenevinylene)s (2007)

Sol–gel tunable red–green–blue (RGB) emission (see figure) is achieved through the functionalization of oligo(p-phenylenevinylene)s (OPVs) with polarizable functional groups, which produce molecular and supramolecular pathways and hence the modulation of the emission properties. The molecules reported are the first example of OPV-based non-hydrogen-bonded quadrupolar π-gels with tunable emission colors and are excellent light-harvesting scaffolds.
Familial tumoral calcinosis. A clinical, histopathologic, and ultrastructural study with an analysis of its calcifying process and pathogenesis. (1993)

We describe histopathologic and ultrastructural changes in tumoral calcinosis (TC) occurring in seven siblings from a single family. Tumoral calcinosis appears to be triggered by bleeding followed by aggregation of foamy histiocytes. These in turn are transformed, with participation of collagenolysis, into cystic cavities lined by osteoclast-like giant cells and histiocytes--the lesion resembling adventitious bursae. Movement and friction, forces generated from the periarticular location of the TC lesions, putatively are key to this transformation. Concomitantly, two calcifying events develop, possibly driven by concurrent hyperphosphatemia or endogenous hypervitaminosis D. One occurs on membranous fragments in antiprotease-containing large cytoplasmic vesicles within osteoclast-like giant cells and mononuclear cells lining the TC cavities; the second, in the TC locules on membranous and cellular debris derived from cavity-lining cells and erythrocytes. The TC cavities ultimately fill with calcified material, losing their synovial-like lining, become encapsulated by fibrous tissue, and ossify. Hydroxyapatite may gain entrance to capillary lumens and embolize to the lung. We conclude that TC represents a disordered reparative process that often is exaggerated because episodes of bleeding, caused by TC-induced vascular injury, provoke development of new lesions. The capricious response of TC to treatment is correlated with its morphologic features.
Capacitive fingerprinting (2012)

At present, touchscreens can differentiate multiple points of contact, but not who is touching the device. In this work, we consider how the electrical properties of humans and their attire can be used to support user differentiation on touchscreens. We propose a novel sensing approach based on Swept Frequency Capacitive Sensing, which measures the impedance of a user to the environment (i.e., ground) across a range of AC frequencies. Different people have different bone densities and muscle mass, wear different footwear, and so on. This, in turn, yields different impedance profiles, which allows for touch events, including multitouch gestures, to be attributed to a particular user. This has many interesting implications for interactive design. We describe and evaluate our sensing approach, demonstrating that the technique has considerable promise. We also discuss limitations, how these might be overcome, and next steps.
A multicentre longitudinal observational study of changes in self reported health status in people with Parkinson's disease left untreated at diagnosis (2006)

This study addresses for the first time self reported health status, an indicator of health related quality of life, in untreated PD. The findings may strengthen the call for re-evaluation of the policy to delay treatment in newly diagnosed patients with PD.