gebhart/patrepeval huggingface dataset:
Wortmannin Sensitizes Mammalian Cells to Radiation by Inhibiting the DNA-Dependent Protein Kinase-Mediated Rejoining of Double-Strand Breaks (1999)

Wortmannin has been shown to be an efficient radiosensitizer. Since wortmannin is able to inhibit DNA-dependent protein kinase (DNA-PK) and double-strand break (DSB) rejoining, it is believed that its mechanism of radiation sensitization is through the inhibition of DNA-PK-mediated repair of DSBs. However, since wortmannin is not a specific inhibitor, the possibility that other kinases are inhibited and thereby may contribute to radiosensitization cannot be ruled out. Here we present data confirming the radiosensitizing effect of wortmannin on cells of different cell lines. In the same range of wortmannin concentrations, survival after exposure to ionizing radiation correlated well with DSB rejoining and the induction of micronuclei, suggesting that the inhibition of the processing of DSBs is involved in the sensitizing effect. Pretreatment with wortmannin enhanced the radiosensitivity of ataxia telangiectasia (AT) cells, thereby precluding the participation of ATM protein in the radiation sensitization by wortmannin. At the same time, irradiated DNA-PK-deficient cells were not significantly affected by pretreatment with wortmannin. These observations support a likely mechanism; that is, wortmannin sensitizes cells to radiation through inhibition of the DNA-PK-mediated rejoining of DSBs.
Charge order as seen by resonant (elastic) X-ray scattering (2012)

We review the main features of charge order observation by means of Resonant (Elastic) X-ray Scattering. Different cases have been studied during the past 12 years (NaV2O5, NdNiO3, Fe3O4, BaVS3, manganites, ...) that have allowed us to develop a systematic approach for data collection, correction and data analysis.
Therapists of patients who committed suicide reported a wide range of emotional responses (2001)

Hendin H, Lipschitz A, Maltsberger JT , et al. Therapists' reactions to patients' suicides. Am J Psychiatry2000 Dec; 157 : 2022 –7. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: What are the emotional responses of therapists to the suicide of a patient? Semi-structured questionnaires and written narrative descriptions for the Suicide Data Bank project. USA. 26 therapists (81% men) who had treated patients who committed suicide. The therapists (21 psychiatrists, 4 psychologists, and 1 psychiatric social worker) had seen the patient for ≥6 visits (treatment ranged from 3–48 mo [median 12 mo]) and had had some contact with the patient in the 2 months before the suicide. Therapists completed a 15–20 page narrative description of the case, demographic and psychodynamic questionnaires, and a semistructured questionnaire that asked about the therapists' reactions. Therapists discussed their cases and their reactions with study authors at a day long workshop. 7 main emotional reactions were reported. Shock or disbelief: many therapists reported they felt either shock or disbelief when they learnt … [1]: {openurl}?query=rft.jtitle%253DAmerican%2BJournal%2Bof%2BPsychiatry%26rft.stitle%253DAm.%2BJ.%2BPsychiatry%26rft.aulast%253DHendin%26rft.auinit1%253DH.%26rft.volume%253D157%26rft.issue%253D12%26rft.spage%253D2022%26rft.epage%253D2027%26rft.atitle%253DTherapists%2527%2BReactions%2Bto%2BPatients%2527%2BSuicides%26rft_id%253Dinfo%253Adoi%252F10.1176%252Fappi.ajp.157.12.2022%26rft_id%253Dinfo%253Apmid%252F11097970%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1176/appi.ajp.157.12.2022&link_type=DOI [3]: /lookup/external-ref?access_num=11097970&link_type=MED&atom=%2Febmental%2F4%2F3%2F96.1.atom [4]: /lookup/external-ref?access_num=000165589400020&link_type=ISI
<title>Characterization of quantum-confined CuCl microcrystals in a glassy matrix</title> (1990)

Quantum confinement effects of semiconductor microcrystallites (CuC1) embedded in a glassy (aluminoborosilicate) matrix are of current interest due to their exceptional nonlinear optical properties. The precipitation of microcrystals occurs upon heat-treatment of a glass in a supersaturated solution. The time and/or temperature of heat-treatment and the degree of supersaturation of the solution determines the size of the microcrystals. This paper characterizes the microcrystals using TEM when the heat-treatment conditions are varied. Room temperature ESR measurements were performed in order to determine the ratio of Cu2 to Cu'' in the glass at various compositions before heat-treatment. Low temperature optical absorption data were jobtained to study the quantum confinement and the effect of varying the microcrystal size. I.
The Emerging Role of CD244 Signaling in Immune Cells of the Tumor Microenvironment (2018)

In cancer, immune exhaustion contributes to the immunosuppressive tumor microenvironment. Exhausted immune cells demonstrate poor effector function and sustained expression of certain immunomodulatory receptors, which can be therapeutically targeted. CD244 is a Signaling Lymphocyte Activation Molecule (SLAM) family immunoregulatory receptor found on many immune cell types-including NK cells, a subset of T cells, DCs, and MDSCs-that represents a potential therapeutic target. Here, we discuss the role of CD244 in tumor-mediated immune cell regulation.
Underwater optical connector for remotely operated submersibles (1984)

A low-loss small-sized underwater optical connector with six optical contacts is presented. An oil-filled optical fibre cord is adopted to simplify the structure. The body of the adaptor is made of synthetic resin which is practically free from erosion. The distribution of stress is calculated by using the finite-element method to evaluate the mechanical strength of the adaptor.
分子生物学—五十年的光辉历程(续) (1989)

1965 揭示琥珀和赭石突变基因分别是链终止密码子 UAG 和 UAA。Weigert,M.G.和 Garen,A.由碱性磷酸酶作用下色氨酸位点的氨基酸的置换证明大肠杆菌中无意义密码子的碱基组成。Nature 206,992～994Brenner,S.,Stretton,A.O.和 Kaplan,S.遗传密码:链终止无意义三联体密码及其抑制。Nature 206,994～998
A highly sensitive ultraviolet sensor based on a facile in situ solution-grown ZnO nanorod/graphene heterostructure (2010)

The weak photon absorption and fast carrier kinetics of graphene limit its application in photodetection. This limitation can be overcome by introducing photosensitive nanostructures to graphene. Herein we report the synthesis of a ZnO nanorod/graphene heterostructure by a facile in situ solution growth method. By combining the attributes of photosensitive ZnO nanorods and highly conductive graphene, we for the first time demonstrate a highly sensitive visible-blind ultraviolet (UV) sensor based on graphene related heterostructure. The photoresponsibility of the UV sensor can reach 22.7 A W(-1), which is over 45,000 fold higher than that of single graphene sheet based photodetectors.
Proposal for sub-femtosecond pulse generation with controlled carrier-envelope phase (2013)

A robust method for producing few-cycle pulses with controlled waveform in the EUV-VUV spectral range by coherent undulator radiation of relativistic ultrathin electron layers produced by inverse free-electron laser (IFEL) action is proposed. The realization of such exceptional pulses will enable time- and CEP-resolved measurements with less than 100 as resolution.
Convolutional Neural Networks Based Intra Prediction for HEVC (2017)

Summary form only given. Traditional intra prediction methods for HEVC rely on using the nearest reference lines for predicting a block, which ignore much richer context between the current block and its neighboring blocks and therefore cause inaccurate prediction especially when weak spatial correlation exists between the current block and the reference lines. To overcome this problem, in this paper, an intra-prediction convolutional neural network (IPCNN) is proposed for intra prediction, which exploits the rich context of the current block and therefore is capable of improving the accuracy of predicting the current block. Meanwhile, the reconstruction of the three nearest blocks can also be refined. To the best of our knowledge, this is the first paper that directly applies CNNs to intra prediction for HEVC. Experimental results validate the effectiveness of applying CNNs to intra prediction and the proposed method can achieve 0.70% bitrate reduction compared to HEVC reference software HM-14.0.
Effect of Fractional Fluorination on the Properties of ATRP Surface-Initiated Poly(hydroxyethyl methacrylate) Films (2004)

Acylation of a surface-initiated poly(hydroxyethyl methacrylate) (PHEMA) film with a perfluoroalkyl acid chloride (C7F15COCl) results in a highly blocking film with fluorocarbon side groups that orient at the air−film interface to produce an ultralow-energy surface. The kinetics of the acylation step was monitored with reflectance-absorption infrared spectroscopy to reveal that the rate of fluorination depends on the chain length and solution concentration of the perfluorinated acid chloride as well as the solvent used. By control of the time of exposure to C7F15COCl, films with fractional conversion of the hydroxyl groups to fluorinated esters between 0 and 0.8 were produced. Increasing fractional conversion from 0 to ∼0.2 has a dramatic effect on surface wettability and electrochemical barrier properties as a densely packed, oriented fluorocarbon surface region is formed that greatly reduces water and ion transport. Additional fluorination has no effect on wettability but gradually increases film resistance while lowering film capacitance. These results suggest that structuring of fluorocarbon groups at the outermost surface of the film has a major impact on film properties and establish the minimum content of fluorocarbon groups required to achieve the structured interface via this grafting process.
Technological realization of low on-resistance FLYMOS/spl trade/ transistors dedicated to automotive applications (2005)

The present 14 Volts automotive electrical system will soon become 42 Volts. For these future automotive applications, development of 80 Volts power MOSFETs exhibiting low on-resistance is desired. The "floating island" MOSFET (FLIMOSFET) is one of the new candidates to break the silicon limit, which is the "specific on-resistance / breakdown voltage" trade-off limit of conventional power MOSFETs. In this paper, the "floating island" concept has been implemented on silicon: new vertical N-channel FLIMOSFETs (FLYMOStrade) dedicated to automotive applications (below 100 Volts) have been fabricated for the first time, using two steps epitaxy process. Experimental results show that FLYMOStrade transistors exhibit lower breakdown voltages than what was expected by simulations (maximum of 73 Volts) but also improved specific on-resistances compared to the conventional VDMOSFET (33% improvement of the specific on-resistance for the same breakdown voltage). In other words, in terms of "specific on-resistance / breakdown voltage" trade-off, the FLYMOStrade is one of the best MOS devices in low voltage applications. These measurements validate the "floating island" concept and the efficiency of the original edge cell that is used in the FLYMOStrade technology
Generalized data stream indexing and temporal query processing (2003)

Presents a novel indexing technique for temporal data stream which are sorted on the effective start time attribute. The index can be exploited in processing complex temporal pattern queries (such as multi-way joins) that are qualified with snapshot operators (e.g. the 'as of' operator). The advantages and limitations of the proposed scheme and a quantitative analysis of the storage requirements are presented. The authors propose some optimization alternatives that can reduce the storage requirements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reliability of Maintained Hull Girders of Two Bulk Carrier Designs Subjected to Fatigue and Corrosion (1999)

The objective of the paper is to study the impact of changing the traditional hull design of bulk carriers by providing them with a double hull while keeping the same deadweight. It is demonstrated that by introducing the double hull the structural reliability is increased throughout the entire life and also the extend of the needed repair is reduced. The results are obtained with recently developed mathematical tools for the reliability assessment of ship hulls subjected to the existence of multiple cracks both in the stiffeners and in the plating and it models the crack growth process. The effect of corrosion is represented as time dependent. The long-term stress range acting on the elements is defined as a function of the local transverse pressure of the internal cargo and outside sea water combined with the stresses resulting from the longitudinal bending of the hull, which is a combined with the stresses resulting from the longitudinal bending of the hull, which is a combineation of horizontal and vertical bending moments. The effect of maintenance actions is modelled as a stochastic process. The results show that a different design of the midship section improves the structural safety and also the economy with respect to structural repair of bulk carriers.
Synthesis and Accumulation of Aromatic Aldehydes in an Engineered Strain of <i>Escherichia coli</i> (2014)

Aromatic aldehydes are useful in numerous applications, especially as flavors, fragrances, and pharmaceutical precursors. However, microbial synthesis of aldehydes is hindered by rapid, endogenous, and redundant conversion of aldehydes to their corresponding alcohols. We report the construction of an Escherichia coli K-12 MG1655 strain with reduced aromatic aldehyde reduction (RARE) that serves as a platform for aromatic aldehyde biosynthesis. Six genes with reported activity on the model substrate benzaldehyde were rationally targeted for deletion: three genes that encode aldo-keto reductases and three genes that encode alcohol dehydrogenases. Upon expression of a recombinant carboxylic acid reductase in the RARE strain and addition of benzoate during growth, benzaldehyde remained in the culture after 24 h, with less than 12% conversion of benzaldehyde to benzyl alcohol. Although individual overexpression results demonstrated that all six genes could contribute to benzaldehyde reduction in vivo, additional experiments featuring subset deletion strains revealed that two of the gene deletions were dispensable under the conditions tested. The engineered strain was next investigated for the production of vanillin from vanillate and succeeded in preventing formation of the byproduct vanillyl alcohol. A pathway for the biosynthesis of vanillin directly from glucose was introduced and resulted in a 55-fold improvement in vanillin titer when using the RARE strain versus the wild-type strain. Finally, synthesis of the chiral pharmaceutical intermediate L-phenylacetylcarbinol (L-PAC) was demonstrated from benzaldehyde and glucose upon expression of a recombinant mutant pyruvate decarboxylase in the RARE strain. Beyond allowing accumulation of aromatic aldehydes as end products in E. coli, the RARE strain expands the classes of chemicals that can be produced microbially via aldehyde intermediates.
Molecular cloning and analysis of a pleiotropic regulatory gene locus from the nystatin producer Streptomyces noursei ATCC11455 (1999)

A regulatory gene locus from Streptomyces noursei ATCC14455, the producer of the antifungal antibiotic nystatin, was cloned in Streptomyces lividans based on its ability to activate actinorhodin (Act) production in this host. Deletion and DNA sequencing analyses showed that a small gene, designated ssmA, located downstream of an afsR homologue (a known pleiotropic regulator) was responsible for the Act overproduction in S. lividans. Database searches for the ssmA gene product revealed its limited similarity to the AfsR2 regulatory protein from S. lividans and CREA catabolite repressor from Aspergillus nidulans. To study the effect of ssmA on nystatin production, this gene was either deleted from S. noursei genome, or placed under control of PermE* promoter and introduced in S. noursei. The properties of the corresponding strains indicate that ssmA is involved in regulation of growth and antibiotic production only in the media with certain carbon sources.
Curcumin Restores Corticosteroid Function in Monocytes Exposed to Oxidants by Maintaining HDAC2 (2008)

Oxidative stress as a result of cigarette smoking is an important etiologic factor in the pathogenesis of chronic obstructive pulmonary disease (COPD), a chronic steroid-insensitive inflammatory disease of the airways. Histone deacetylase-2 (HDAC2), a critical component of the corticosteroid anti-inflammatory action, is impaired in lungs of patients with COPD and correlates with disease severity. We demonstrate here that curcumin (diferuloylmethane), a dietary polyphenol, at nanomolar concentrations specifically restores cigarette smoke extract (CSE)- or oxidative stress-impaired HDAC2 activity and corticosteroid efficacy in vitro with an EC(50) of approximately 30 nM and 200 nM, respectively. CSE caused a reduction in HDAC2 protein expression that was restored by curcumin. This decrease in HDAC2 protein expression was reversed by curcumin even in the presence of cycloheximide, a protein synthesis inhibitor. The proteasomal inhibitor, MG132, also blocked CSE-induced HDAC2 degradation, increasing the levels of ubiquitinated HDAC2. Biochemical and gene chip analysis indicated that curcumin at concentrations up to 1 muM propagates its effect via antioxidant-independent mechanisms associated with the phosphorylation-ubiquitin-proteasome pathway. Thus curcumin acts at a post-translational level by maintaining both HDAC2 activity and expression, thereby reversing steroid insensitivity induced by either CSE or oxidative stress in monocytes. Curcumin may therefore have potential to reverse steroid resistance, which is common in patients with COPD and asthma.
Indole metabolites from a strain of Aspergillus flavus (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIndole metabolites from a strain of Aspergillus flavusRichard J. Cole, Joe W. Dorner, James P. Springer, and Richard H. CoxCite this: J. Agric. Food Chem. 1981, 29, 2, 293–295Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/jf00104a019https://doi.org/10.1021/jf00104a019research-articleACS PublicationsRequest reuse permissionsArticle Views223Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Loss of Let-7 Up-Regulates EZH2 in Prostate Cancer Consistent with the Acquisition of Cancer Stem Cell Signatures That Are Attenuated by BR-DIM (2012)

The emergence of castrate-resistant prostate cancer (CRPC) contributes to the high mortality of patients diagnosed with prostate cancer (PCa), which in part could be attributed to the existence and the emergence of cancer stem cells (CSCs). Recent studies have shown that deregulated expression of microRNAs (miRNAs) contributes to the initiation and progression of PCa. Among several known miRNAs, let-7 family appears to play a key role in the recurrence and progression of PCa by regulating CSCs; however, the mechanism by which let-7 family contributes to PCa aggressiveness is unclear. Enhancer of Zeste homolog 2 (EZH2), a putative target of let-7 family, was demonstrated to control stem cell function. In this study, we found loss of let-7 family with corresponding over-expression of EZH2 in human PCa tissue specimens, especially in higher Gleason grade tumors. Overexpression of let-7 by transfection of let-7 precursors decreased EZH2 expression and repressed clonogenic ability and sphere-forming capacity of PCa cells, which was consistent with inhibition of EZH2 3'UTR luciferase activity. We also found that the treatment of PCa cells with BR-DIM (formulated DIM: 3,3'-diindolylmethane by Bio Response, Boulder, CO, abbreviated as BR-DIM) up-regulated let-7 and down-regulated EZH2 expression, consistent with inhibition of self-renewal and clonogenic capacity. Moreover, BR-DIM intervention in our on-going phase II clinical trial in patients prior to radical prostatectomy showed upregulation of let-7 consistent with down-regulation of EZH2 expression in PCa tissue specimens after BR-DIM intervention. These results suggest that the loss of let-7 mediated increased expression of EZH2 contributes to PCa aggressiveness, which could be attenuated by BR-DIM treatment, and thus BR-DIM is likely to have clinical impact.
Mathematical Model of a Direct Methanol Fuel Cell (2004)

Abstract A one-dimensional, isothermal model for a direct methanol fuel cell (DMFC) is presented. This model accounts for the kinetics of the multi-step methanol oxidation reaction at the anode. Diffusion and crossover of methanol are modeled and the mixed potential of the oxygen cathode due to methanol crossover is included. Kinetic and diffusional parameters are estimated by comparing the model to data from a 25cm2 DMFC. This semi-analytical model can be solved rapidly so that it is suitable for inclusion in real-time system level DMFC simulations.
Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer (2011)

Insulin-like growth factor (IGF) signaling has been implicated in the resistance to hormonal therapy in breast cancer. Using a model of postmenopausal, estrogen-dependent breast cancer, we investigated the antitumor effects of the dual IGF-1R/InsR tyrosine kinase inhibitor BMS-754807 alone and in combination with letrozole or tamoxifen. BMS-754807 exhibited antiproliferative effects in vitro that synergized strongly in combination with letrozole or 4-hydroxytamoxifen and fulvestrant. Similarly, combined treatment of BMS-754807 with either tamoxifen or letrozole in vivo elicited tumor regressions not achieved by single-agent therapy. Notably, hormonal therapy enhanced the inhibition of IGF-1R/InsR without major side effects in animals. Microarray expression analysis revealed downregulation of cell-cycle control and survival pathways and upregulation of erbB in response to BMS-754807 plus hormonal therapy, particularly tamoxifen. Overall, these results offer a preclinical proof-of-concept for BMS-754807 as an antitumor agent in combination with hormonal therapies in hormone-sensitive breast cancer. Cooperative cell-cycle arrest, decreased proliferation, and enhanced promotion of apoptosis may contribute to antitumor effects to be gauged in future clinical investigations justified by our findings.
Gewinnung von 1;4‐Bisdehydro‐3‐oxo‐steroiden. Über Steroide, 139. Mitteilung (1956)

Abstract A method is described which enables the production in only one chemical step of 1,4‐bisdehydro‐3‐oxo‐steroids inter alia from 3‐oxo‐ steroids saturated in ring A or from the α β‐mono‐unsaturated 3‐ketones. The dehydrogenating agent is selenium dioxide and the solvent a tertiary alcohol preferably containing some acid.