gebhart/patrepeval huggingface dataset:
Personalized Alert Notifications and Evacuation Routes in Indoor Environments (2012)

The preparedness phase is crucial in the emergency management process for reaching an adequate level of readiness to react to potential threats and hazards. During this phase, emergency plans are developed to establish, among other procedures, evacuation and emergency escape routes. Information and Communication Technologies (ICT) can support and improve these procedures providing appropriate, updated and accessible information to all people in the affected zone. Current emergency management and evacuation systems do not adapt information to the context and the profile of each person, so messages received in the emergency might be useless. In this paper, we propose a set of criteria that ICT-based systems could achieve in order to avoid this problem adapting emergency alerts and evacuation routes to different situations and people. Moreover, in order to prove the applicability of such criteria, we define a mechanism that can be used as a complement of traditional evacuation systems to provide personalized alerts and evacuation routes to all kinds of people during emergency situations in working places. This mechanism is composed by three main components: CAP-ONES for notifying emergency alerts, NERES for defining emergency plans and generating personalized evacuation routes, and iNeres as the interface to receive and visualize these routes on smartphones. The usability and understandability of proposed interface has been assessed through a user study performed in a fire simulation in an indoor environment. This evaluation demonstrated that users considered iNeres easy to understand, to learn and to use, and they also found very innovative the idea to use smartphones as a support for escaping instead of static signals on walls and doors.
Intelligent Intersection Management Systems Considering Autonomous Vehicles: A Systematic Literature Review (2019)

Over the past several decades, the development of technologies and the production of autonomous vehicles have enhanced the need for intelligent intersection management systems. Subsequently, growing interest in studying the traffic management of autonomous vehicles at intersections has been evident, which indicates a critical need to conduct a systematic literature review on this topic. This paper offers a systematic review of the proposed methodologies for intelligent intersection management systems and presents the remaining research gaps and possible future research approaches. We consider both pure autonomous vehicle traffic and mixed traffic at four-way signalized and unsignalized intersection(s). We searched for articles published from 2008 to 2019, and identified 105 primary studies. We applied the thematic analysis method to analyze the extracted data, which led to the identification of four main classes of methodologies, namely rule-based, optimization, hybrid, and machine learning methods. We also compared how well the methods satisfy their goals, namely efficiency, safety, ecology, and passenger comfort. This analysis allowed us to determine the primary challenges of the presented methodologies and propose new approaches in this area.
PSTPIP Is a Substrate of PTP-PEST and Serves as a Scaffold Guiding PTP-PEST Toward a Specific Dephosphorylation of WASP (2002)

PSTPIP is a tyrosine-phosphorylated protein involved in the organization of the cytoskeleton. Its ectopic expression induces filipodial-like membrane extensions in NIH 3T3 cells. We previously observed a defect in cytokinesis and an increase in the tyrosine phosphorylation of PSTPIP in PTP-PEST-deficient fibroblasts. In this article, we demonstrate that PTP-PEST and PSTPIP are found in the same complexes in vivo and that they interact directly through the CTH domain of PTP-PEST and the coiled-coil domain of PSTPIP. We tested pathways that could regulate the tyrosine phosphorylation of PSTPIP. We found that the activation of the epidermal growth factor and platelet-derived growth factor receptors can induce PSTPIP phosphorylation. With the use of the PP2 inhibitor, we demonstrate that Src kinases are not involved in the epidermal growth factor-mediated phosphorylation of PSTPIP. Together with previous results, this suggests that c-Abl is the critical tyrosine kinase downstream of growth factor receptors responsible for PSTPIP phosphorylation. We also demonstrate that PTP-PEST dephosphorylates PSTPIP at tyrosine 344. Importantly, we identified tyrosine 344 as the main phosphorylation site of PSTPIP by performing tryptic phosphopeptide maps. This is an important finding since tyrosine 367 of PSTPIP was also proposed as a candidate phosphorylation site involved in the negative regulation of the association between PSTPIP and WASP. In this respect, we observed that the PSTPIP.WASP complex is stable in vivo and is not affected by the phosphorylation of PSTPIP. Furthermore, we demonstrate that PSTPIP serves as a scaffold protein between PTP-PEST and WASP and allows PTP-PEST to dephosphorylate WASP. This finding suggests a possible mechanism for PTP-PEST to directly modulate actin remodeling through the PSTPIP-WASP interaction.
Human finding and body property estimation by using floor segmentation and 3D labelling (2005)

This paper describes a human finding and body property estimation system, which is able to recognize the floor surface and humans from distance information obtained from a stereo camera. The system is comprised of two algorithms; random two point sampling method and, 3D labeling method. The random two point sampling method can detect three-dimensional planer surfaces so as to recognize floor surface from input depth map. The 3D labeling method can recognize humans from dense disparity map by omitting the floor detected in the previous procedure. Finally the system estimate body height from the depth map and uses this to estimate head and leg length from regression formula in an anthology of human body measurement.
[An epidemic outbreak of respiratory infection caused by Chlamydia pneumoniae in medical workers]. (2006)

The colony occurrences and similar clinical and chest imaging manifestations are characteristics of an outbreak of respiratory infection caused by CP in medical workers. An outbreak of respiratory infection caused by CP should be differentiated from severe acute respiratory syndrome (SARS).
Therapeutic potential of blocking HIV entry into cells: focus on membrane fusion inhibitors (1999)

Despite a number of recent therapeutic advancements, there remains an urgent need to develop a new class of therapy for human immunodeficiency virus (HIV). This review summarises attempts at blocking HIV binding and entry into host cells, an approach that would provide theoretical advantages over the currently available drugs targeting enzymes (reverse transcriptase and protease), brought into play in the later stages of the viral life cycle. The multi-step process of HIV entry into cells, binding of the surface glycoprotein (gp120) to the CD4 receptor and one of the chemokine receptors, followed by the membrane fusion step mediated by the transmembrane glycoprotein (gp41), has recently been understood with greater clarity. The importance of the chemokine co-receptors, such as CCR5 and CXCR4, for HIV entry may help to explain the limitations of earlier approaches using recombinant soluble CD4 or polyanionic compounds to interfere non-specifically with HIV glycoprotein function. Conversely, previous investigations demonstrating the in vitro inhibitory potential of beta chemokines themselves, or small-molecule chemokine receptor inhibitors, may now be understood in a new light. Promising laboratory investigations (particularly with the bicyclam compound, AMD3100) and extensive pharmaceutical experience with related chemical structures suggest great potential for targeting the chemokine nexus. Finally, the evolution of transmembrane peptide investigations from the laboratory to early clinical trials is described. Clinical trials of T-20, a peptide designed to inhibit gp-41 mediated fusion, have provided 'proof of concept' that therapeutics targeting a viral entry event can result in safe and potent inhibition of viral replication. The author speculates on the future prospect of using novel therapeutic strategies aimed at the initial interactions between HIV and target cells, in the battle against AIDS.
Teaching Johnny not to fall for phish (2010)

Phishing attacks, in which criminals lure Internet users to Web sites that spoof legitimate Web sites, are occurring with increasing frequency and are causing considerable harm to victims. While a great deal of effort has been devoted to solving the phishing problem by prevention and detection of phishing emails and phishing Web sites, little research has been done in the area of training users to recognize those attacks. Our research focuses on educating users about phishing and helping them make better trust decisions. We identified a number of challenges for end-user security education in general and anti-phishing education in particular: users are not motivated to learn about security; for most users, security is a secondary task; it is difficult to teach people to identify security threats without also increasing their tendency to misjudge nonthreats as threats. Keeping these challenges in mind, we developed an email-based anti-phishing education system called “PhishGuru” and an online game called “Anti-Phishing Phil” that teaches users how to use cues in URLs to avoid falling for phishing attacks. We applied learning science instructional principles in the design of PhishGuru and Anti-Phishing Phil. In this article we present the results of PhishGuru and Anti-Phishing Phil user studies that demonstrate the effectiveness of these tools. Our results suggest that, while automated detection systems should be used as the first line of defense against phishing attacks, user education offers a complementary approach to help people better recognize fraudulent emails and websites.
Backfat quality in boars and barrows at 90 kg live weight (1985)

ABSTRACT Forty male commercial hybrid pigs, half castrated at 10 days of age, were used in a study to determine whether boars at bacon weight (90 kg live weight) have different fat quality from barrows. Fat quality was defined as the firmness and cohesiveness of subcutaneous fat, both properties being measured using an Instron materials testing instrument. Within each group of boars and barrows, half the pigs were fed a normal commercial diet and half a lower energy diet at a lower level of food intake. The latter diet provided relatively more energy as C18:2 (linoleic acid). Firmness of subcutaneous fat was related to fat thickness and to concentrations of the chemical components in the fat which are affected by fat thickness. The single best predictor of firmness was C18:0 (stearic acid). Cohesiveness was less closely related to fat thickness and was most associated with the concentration of C18:2. On the low energy/high C18:2 diet, all the pigs were judged to have soft fat, the difference between boars and barrows being small and explained by the difference in fat thickness. On the normal commercial diet, some barrows had particularly firm fat but they had thicker fat than any of the boars. Most (0·84) of the pigs in the experiment had P 2 values (fat thickness over the m. longissimus at the last rib) between 8 and 15 mm. In this range there was no difference in firmness between boars and barrows. Cohesiveness was also similar between boars and barrows.
A critical review of selective serotonin reuptake inhibitor-related sexual dysfunction; incidence, possible aetiology and implications for management (1997)

There is a high incidence of sexual dysfunction in the general population and sexual dysfunction is often an integral symptom of a depressive disorder. In addition, all antidepressants have effects on sexual functioning, as the result of side-effects of these medications and as a reflection of therapeutic success. The selective serotonin reuptake inhibitors (SSRIs) are clearly associated with delayed ejaculation, inability to ejaculate and absent or delayed orgasm. Furthermore, the incidence of sexual dysfunction obtained by patient self-report does not appear to reflect the true incidence of sexual dysfunction associated with antidepressant therapy and systematic inquiry is needed as sexual dysfunction may be an unrecognized cause of noncompliance. The SSRIs may have advantageous effects on sexual functioning and these may also be underreported due to the same factors resulting in an under-reporting of sexual side-effects in general. In addition, studies have suggested a role for the SSRIs in the management of premature ejaculation. The effects of SSRIs on sexual functioning are clearly dose-related and may vary amongst the group due to their relative effects on the serotonin and dopamine systems and the extent to which plasma levels of these drugs accumulate in the body over time. A variety of strategies have been found useful in the management of SSRI-induced sexual dysfunction including waiting for tolerance to develop, dosage reduction, drug holidays, switching to a different antidepressant and various augmentation strategies with 5-HT2, alpha2 adrenergic receptor antagonists and dopamine receptor agonists.
Mast Cells: Methods And Protocols (2005)

The mast cell, long implicated in causing allergic reactions, may also be involved in many other disease processes, including cancer, heart disease, parasitic disease, atherosclerosis, asthma, and arthritis. In Mast Cells: Methods and Protocols, hands-on experts describe in detail their best techniques for the isolation, culture, and study of both activation and signaling in human mast cells. These readily reproducible methods take advantage of the latest advances in molecular biology, technology, and information science. The techniques provide a sound base of methodology for mast cell research and include methods for the identification of mast cells, the development of mast cells in vitro, the study of mast cell signaling and gene expression, and the measurement of mast cell expression of inflammatory mediators. Additional chapters cover methods for studying mast cell interactions with other cell types (endothelial cells, fibroblasts, and B cells), the roles of mast cells in host defense, and mast cell apoptosis. A survey of mast cell biology offers insight into its history and the implications for adaptive immunity. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and highly practical, Mast Cells: Methods and Protocols provides mast cell researchers with reproducible accounts of basic and advanced molecular and cellular techniques used in studying this fascinating, multifunctional cell
Interactions among stratum corneum defensive functions (2005)

With the exception of vitamin D production, virtually all epidermal functions can be considered as protective, or more specifically, as defensive in nature. Yet, the term "barrier function" of the stratum corneum (SC) is often used synonymously with only one such defensive function, although arguably its most important, i.e., permeability barrier homeostasis. Regardless of their hierarchy of relative importance, these critical protective functions largely reside in the SC. In this short review, we explore the ways in which the multiple defensive functions of the SC are linked and interrelated, either by their shared localization or by common biochemical processes.
Combination antiretroviral drugs in PLGA nanoparticle for HIV-1 (2009)

These results demonstrated AR NPs could be fabricated containing three antiretroviral drugs (RTV, LPV, EFV). Sustained release of AR from PLGA NP show high drug levels in PBMCs until day 28 without cytotoxicity.
Integration of all data fusion levels using a blackboard architecture (1998)

The data fusion model generally accepted, with its process refinement capability, implicitly supposes that all levels of fusion are integrated. A tight integration is essential to gain the maximum benefits from the data fusion process. Unfortunately, the research and development effort in the data fusion domain has generally been done in a fragmented way. Most of the time, the functionalities of one level of fusion have been studied independently from the other levels and, consequently, they have also been implemented on independent test beds. This paper proposes a framework for integrated data fusion composed of a number of interconnected data fusion sub-processes or agents within a closed loop environment. All data fusion agents within the framework are required to comply with the data fusion notion of process refinement. The paper also presents an approach, making use of a blackboard architecture, to achieve the required integration of all data fusion levels. Blackboard systems are well known for their inherent potential to serve as the integration framework for problem-solving systems of a collaborative type. Finally, the migration and expansion of an existing sensor fusion test bed towards a new proof of concept tool for sensor fusion and situation awareness, based on a commercial blackboard system architecture, is discussed.
Synthesis of Some Dialkyl Bromo‐Substituted Benzyl Phosphonates (1984)

Abstract Arbuzov reaction of bromo‐substituted benzyl bromides and trialkyl phosphites in benzene gave high yields of dialkyl bromo‐substituted benzyl phosphonates, and —CH 2 CH 2 CH 2 CH 3 ). The structural assignments of these phosphonates were confirmed by 1 H nmr , 13 C nmr, ir and mass spectral analysis.
Using Chemical Tracers for Flow Profiling a Subsea Horizontal Well with an Open Hole Gravel Pack Lower Completion: Field Results (2008)

Abstract This paper presents the first case study on using chemical tracers for flow profiling a subsea horizontal well with an open hole gravel pack lower completion in Enfield field, Australia. The principle of the technology involves positioning a number of different tracer materials, each at specific locations along the length of lower completions, prior to lowering downhole. The tracers are selected to be soluble in either crude oil or water. Upon well start up, oil samples are taken at the surface over a short period of time. These samples are analysed to determine tracer presence. The presence of one or a combination of unique tracers within the oil sample, along with the known location of each tracer downhole, allows qualitative information to be generated about fluid flow in the well. Chemical tracers for flow profiling were chosen for ENA03L1, an oil well intersecting a number of fault blocks in the south of the Enfield field to: Provide direct proof of fluid flow from different fault blocks;Improve understanding of well clean up of a horizontal well, especially the contribution from the toe of the well; andDetect the location of water breakthrough. Results showed that within four hours of the initial clean up, all oil soluble tracers were detected, providing positive confirmation that the intervals tagged, including the toe of the well, were contributing to the overall production. Using tracers for flow profiling horizontal well provides the following benefits: Enables flow position to be verified in long horizontal wells; andComparatively inexpensive when compared to horizontal well production log costs. This case study recounts the design, installation, analysis, results and subsequent learnings of the project.
The Levels of Cytokines and Nitric Oxide in Rabbit Vitreous Humor after Retinal Laser Photocoagulation (2000)

Our results support that especially IL-6, IL-8, and NO levels increase significantly following laser photocoagulation. This preliminary study suggests that IL-6, IL-8, and NO might be dominant contributing factors in the occurrence of the inflammation postoperatively.
[The quality of life in patients with ENT pathology]. (2009)

The main results of a medico-sociological study are reported with special reference to the assessment of medico-social status and quality of life in patients with ENT pathology who were treated in a commercial medical centre. The study demonstrated that ENT diseases have negative effect on the working capacity, sleep, and the ability to perform physical exercises. In more than half of the respondents, pathological changes in ENT organs turned out to be a cause of deterioration of family relationships and the resulting impairment of the quality of life.
Global distance-based segmentation of trajectories (2006)

This work introduces distance-based criteria for segmentation of object trajectories. Segmentation leads to simplification of the original objects into smaller, less complex primitives that are better suited for storage and retrieval purposes. Previous work on trajectory segmentation attacked the problem locally, segmenting separately each trajectory of the database. Therefore, they did not directly optimize the inter-object separability, which is necessary for mining operations such as searching, clustering, and classification on large databases. In this paper we analyze the trajectory segmentation problem from a global perspective, utilizing data aware distance-based optimization techniques, which optimize pairwise distance estimates hence leading to more efficient object pruning. We first derive exact solutions of the distance-based formulation. Due to the intractable complexity of the exact solution, we present an approximate, greedy solution that exploits forward searching of locally optimal solutions. Since the greedy solution also imposes a prohibitive computational cost, we also put forward more lightweight variance-based segmentation techniques, which intelligently "relax" the pairwise distance only in the areas that affect the least the mining operations. Copyright 2006 ACM.
Thyroxine analogs. XIX. 3,5-Dimethyl-3'-isopropyl-DL-thyronine (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThyroxine analogs. XIX. 3,5-Dimethyl-3'-isopropyl-DL-thyronineEugene C. Jorgensen and Jeremy. WrightCite this: J. Med. Chem. 1970, 13, 4, 745–747Publication Date (Print):July 1, 1970Publication History Published online1 May 2002Published inissue 1 July 1970https://pubs.acs.org/doi/10.1021/jm00298a041https://doi.org/10.1021/jm00298a041research-articleACS PublicationsRequest reuse permissionsArticle Views48Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts