gebhart/patrepeval huggingface dataset:
Genetic and nutrient modulation of acetyl-CoA levels in Synechocystis for n-butanol production (2015)

These results demonstrate that phosphoketolase overexpression and modulation of nitrogen levels are two attractive routes toward increased production of acetyl-CoA derived products in cyanobacteria and could be implemented with complementary metabolic engineering strategies.
Doping Pd/SiO<sub>2</sub> with Na<sup>+</sup>: changing the reductive etherification of CO to furan ring hydrogenation of furfural in ethanol (2019)

The production of biofuels and chemicals by hydrogenation of furfural has attracted much attention recently. Herein the effect of Na<sup>+</sup> doping on the catalytic performance of Pd/SiO<sub>2</sub> in hydrogenation and reductive-etherification of furfural in ethanol was systematically studied. Two Pd/SiO<sub>2</sub> catalysts with and without the modification by Na<sup>+</sup> were prepared by impregnation and calcination. Their catalytic properties were compared for the hydrogenation of furfural and furfural diethyl acetal under mild conditions. The silanol groups on Pd/SiO<sub>2</sub> catalysed the acetalization of furfural and alcohol and the resulted acetal underwent hydrogenolysis on Pd nanoparticles (NPs) with an average particle size of 8 nm, leading to a moderate yield (∼58%) of furfuryl ethyl ether. Doping Na<sup>+</sup> on Pd/SiO<sub>2</sub> led to the diminishing of silanol groups as well as strong interaction between Na<sup>+</sup> and Pd NPs. No acetalization occurred on Na<sup>+</sup> modified Pd/SiO<sub>2</sub> due to the exchange of H<sup>+</sup> of Si-OH with Na<sup>+</sup>, thus the reductive etherification of C[double bond, length as m-dash]O group in furfural was completely inhibited. Meanwhile the hydrogenation of furan-ring over Na<sup>+</sup> coordinated Pd NPs could proceed with very high selectivity (>90%) forming tetrahydrofurfural in high yield. Kinetics study on the hydrogenation of furfural diethyl acetal over Pd/SiO<sub>2</sub> and Na<sup>+</sup> doped Pd/SiO<sub>2</sub> suggested that the Na<sup>+</sup> greatly impeded the hydrogenolysis of C-O-C bond of acetal, while the hydrogenation of the furan ring took place selectively.
Three-Year, Randomized, Sham-Controlled Trial of Dexamethasone Intravitreal Implant in Patients with Diabetic Macular Edema (2014)

The DEX implant 0.7 mg and 0.35 mg met the primary efficacy endpoint for improvement in BCVA. The safety profile was acceptable and consistent with previous reports.
The Malaria Parasite and its Life-cycle (1999)

The life cycle of the malaria parasite is complex (Figure 2. 1). The sporozoites are transmitted to humans by the bite of infected female mosquitoes of the genus Anopheles. The sporozoites circulate for a short time in the blood stream, then invade liver cells, where they develop into exoerythrocytic schizonts during the next 5 to 15 days. Plasmodium vivax, P. ovale and P. cynomolgi have a dormant stage, the hypnozoite (Krotoski et aI. , 1982a and b), that may remain in the liver for weeks or many years before the development of exoerythrocytic schizogony. This results in relapses of infection. Plasmodium Jalciparum and P. malariae have no persistent phase. An exoerythrocytic schizont contains 10000 to 30 000 merozoites, which are released and invade the red blood cells. Erythrocyte invasion by merozoites is dependent on the interactions of specific receptors on the erythrocyte membrane with ligands on the surface of the merozoite. The entire invasion process takes about 30 seconds. The merozoite develops within the erythrocyte through ring, trophozoite and schizont (erythrocytic schizogony). The parasite modifies its host cell in several ways to enhance its survival. The erythrocyte containing the segmented schizont eventually ruptures and releases the merozoites, which invade additional erythrocytes. In the course of these events, some merozoites invade erythrocytes, become differentiated into sexual forms, which are macrogametocytes (female) and microgametocytes (male). The durationr3:�. AI/G�J'� r 0 Q ill: . , . C3 � . ,. 'GO¥e0e6'�rooi �G��40� ¢oof gametocytogony is assumed to be approximately 4 to 10 days depending on the Plasmodium species. Maturc macrogametocytes taken into the midgut of the Anopheles mosquito escape from the erythrocyte to form macrogametes . Microgametocytes in the midgut exflagellate, each forms 8 micro gametes after a few minutes postinfection. The microgamete moves quickly to fertilize a macrogamete and forms a zygote. Within 1 8 to 24 hours, the zygote elongates into a slowly motile ookinete . The ookinete traverses the peri trophic membrane and the epithelial cell of the midgut, and then transforms into an oocyst beneath the basement membrane of the midgut epithelium. Between 7 and 1 5 days postinfection, depending on the Plasmodium species and ambient temperature, a single oocyst forms more than 1 0000 sporozoites . The motile sporozoites migrate into the salivary glands and accumulate in the acinar cells of the salivary glands . When an infected mosquito bites a susceptible vertebrate host, the Plasmodium life-cycle begins again.
What is the function of phospholipid <i>N</i>-methylation? (1983)

Research Article| July 01 1983 What is the function of phospholipid N-methylation? J M Mato; J M Mato Search for other works by this author on: This Site PubMed Google Scholar S Alemany S Alemany Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1983) 213 (1): 1–10. https://doi.org/10.1042/bj2130001 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation J M Mato, S Alemany; What is the function of phospholipid N-methylation?. Biochem J 1 July 1983; 213 (1): 1–10. doi: https://doi.org/10.1042/bj2130001 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1983 London: The Biochemical Society1983 Article PDF first page preview Close Modal You do not currently have access to this content.
Cluster analysis methods for recognition of mineral rocks in the mining industry (2014)

This paper contains short description of cluster analysis algorithm for the mineral rock recognition in the mining industry. In this paper it describes the algorithm for automatic segmentation of color images of rocks, using the methods of cluster analysis. There are results of studies different color spaces for clustering k-means. Some realizations of this algorithm for computing the grading of mineral rocks are presented here. As a result it was determined color space provided sufficient quality rocks segmentation by the method of cluster analysis. It was supposed the technique of pre-computing the values of the centroids. There is formulas translation metrics color space HSV. The effectiveness of the proposed method lies in the automatic identification of objects of interest on the total image, tuning parameters of the algorithm is a number that indicates the amount allocated to the segments. Few examples concerning with cluster analysis algorithm in the solving of mineral rock recognition problems are described and discussed.
Extensive TD-DFT Benchmark: Singlet-Excited States of Organic Molecules (2009)

Extensive Time-Dependent Density Functional Theory (TD-DFT) calculations have been carried out in order to obtain a statistically meaningful analysis of the merits of a large number of functionals. To reach this goal, a very extended set of molecules (∼500 compounds, >700 excited states) covering a broad range of (bio)organic molecules and dyes have been investigated. Likewise, 29 functionals including LDA, GGA, meta-GGA, global hybrids, and long-range-corrected hybrids have been considered. Comparisons with both theoretical references and experimental measurements have been carried out. On average, the functionals providing the best match with reference data are, one the one hand, global hybrids containing between 22% and 25% of exact exchange (X3LYP, B98, PBE0, and mPW1PW91) and, on the other hand, a long-range-corrected hybrid with a less-rapidly increasing HF ratio, namely LC-ωPBE(20). Pure functionals tend to be less consistent, whereas functionals incorporating a larger fraction of exact exchange tend to underestimate significantly the transition energies. For most treated cases, the M05 and CAM-B3LYP schemes deliver fairly small deviations but do not outperform standard hybrids such as X3LYP or PBE0, at least within the vertical approximation. With the optimal functionals, one obtains mean absolute deviations smaller than 0.25 eV, though the errors significantly depend on the subset of molecules or states considered. As an illustration, PBE0 and LC-ωPBE(20) provide a mean absolute error of only 0.14 eV for the 228 states related to neutral organic dyes but are completely off target for cyanine-like derivatives. On the basis of comparisons with theoretical estimates, it also turned out that CC2 and TD-DFT errors are of the same order of magnitude, once the above-mentioned hybrids are selected.
A Meta-Level Specification and Profile for AspectJ in UML. (2007)

Aspect-oriented programming (AOP) has become a mature technology. Increasingly, calls for support of AOP on the software model level are being voiced. This paper addresses these calls by offering a meta-model of AspectJ in UML. Using the UML extension mechanisms, the resulting meta-model is also a UML profile for supporting AspectJ modelling in UML. In contrast to previous work, this profile offers complete meta-level integration of all AspectJ concepts. Moreover, the use of standard XMI based modelling allows the use of the profile in commercially available CASE tools and supports easy code generation.
Concordance between the CC Chemokine Receptor 5 Genetic Determinants That Alter Risks of Transmission and Disease Progression in Children Exposed Perinatally to Human Immunodeficiency Virus (2001)

If CC chemokine receptor 5 (CCR5)-dependent mechanisms at the time of initial virus exposure are important determinants of virus entry and disease outcome, then the polymorphisms in CCR5 that influence risk of transmission and disease progression should be similar; this hypothesis was tested in a cohort of 649 Argentinean children exposed perinatally to human immunodeficiency virus type 1 (HIV-1). Two lines of evidence support this hypothesis. First, CCR5 haplotype pairs associated with enhanced risk of transmission were the chief predictors of a faster disease course. Second, some of the haplotype pairs associated with altered rates of transmission and disease progression in children were similar to those that we previously found influenced outcome in European American adults. This concordance suggests that CCR5 haplotypes may serve as genetic rheostats that influence events occurring shortly after initial virus exposure, dictating not only virus entry but, by extension, also the extent of early viral replication.
A comparison of list schedules for parallel processing systems (1974)

The problem of scheduling two or more processors to minimize the execution time of a program which consists of a set of partially ordered tasks is studied. Cases where task execution times are deterministic and others in which execution times are random variables are analyzed. It is shown that different algorithms suggested in the literature vary significantly in execution time and that the B-schedule of Coffman and Graham is near-optimal. A dynamic programming solution for the case in which execution times are random variables is presented.
PG-ISFET based DNA-logic for reaction monitoring (2010)

A report on the use of programmable gate-ion sensitive field effect transistors (PG-ISFETs) to form DNA-logic gates for reaction monitoring is presented. A PG-ISFET sensor is integrated with standard MOSFETs to form a chemical-inverter that switches when a chemical reaction reaches a certain threshold. By employing feedback to the electrical gate rapid switching is achieved for changes in pH as low as 0.1 units, overcoming limitations of voltage division owing to passivation capacitance of CMOS based ISFETs. Using this, DNA-logic arrays can be synthesised to carry out highly parallel chemical processing functions for applications such as DNA sequencing.
Mozambique - Technical and Vocational Education and Training Project : environmental assessment (2005)

The Technical and Vocational Education and Training (TVET) Project in Mozambique aims to transform the TVET system to respond more effectively, equitably, and in a timely, articulated manner to labor market needs, while sensitive to gender and HIV/AIDS issues. Notwithstanding, it is envisaged the project may have negative environmental impact, namely due to construction works, and it is to this end, this environmental and social management framework (ESMF) provide the guidelines for the different stages of the environmental and social screening process, which will determine whether no environmental work will be required; or the implementation of simple mitigation measures will suffice; or, if a separate environmental impact assessment (EIA) will be required. The report stresses the need for capacity building for environmental management and monitoring, required both at the national and provincial levels, to apply the screening process as outlined herewith. As necessary, members of the Technical Review Committee will receive training regarding environmental aspects, who will then make effective recommendations for approval/disapproval of construction and rehabilitation activities. The report further lists the institutions responsible for implementing, and monitoring the mitigation measures.
Improved Synthesis of <i>tert</i>-Butanesulfinamide Suitable for Large-Scale Production (2003)

[reaction: see text] An improved synthesis of tert-butanesulfinamide that overcomes the scalability problems of the previous syntheses is described. The key step is the catalytic asymmetric oxidation of the inexpensive di-tert-butyl disulfide starting material. The new homogeneous reaction conditions utilize an inexpensive chiral ligand prepared in a single step from commercially available cis-1-amino-indan-2-ol. The reaction is performed at a 2.3 M concentration in the practical solvent acetone and can readily be run on a kilogram scale.
Enterovirus 71 Infection of Human Immune Cells Induces the Production of Proinflammatory Cytokines (2009)

A proinflammatory cytokine storm has been proposed to explain the pathogenesis of enterovirus 71 (EV71)-induced fatalities; however, the mechanism to induce these cytokines during EV71 infection remains unclear. Since most of the proinflammatory cytokines are produced by immune cells, we tested whether EV71 infects human immune cells and induces cytokine production. EV71 infection of a human T cell line (Jurkat), macrophage cell line (THP-1), and freshly isolated human peripheral blood mononuclear cells was demonstrated using RT-PCR and immunofluorescence assays in vitro. In addition, live but not UV-inactivated EV71 increased the secretion of two proinflammatory cytokines, tumor necrosis factor-α (TNF-α) and macrophage migration inhibitory factor (MIF) by immune cells, which was inhibited in the presence of actinomycin D. RT-PCR further confirmed that EV71 infection of immune cells triggered the de novo synthesis of MIF mRNA. Therefore, our results suggest that the production of TNF-α and MIF induced by EV71 infection of immune cells may contribute to the proinflammatory cytokine storm during EV71 infection.
ROLE OF FILTERING TECHNIQUES IN COMPUTED TOMOGRAPHY (CT) IMAGE RECONSTRUCTION (2015)

With the arrival of Computed tomography (CT) as a diagnostic tool in the field of medical imaging, the field of X-ray imaging got revolutionized. The CT technology processes various images which are taken at different angles in order to produce the crosssectional images of the specific part of the object with the help of a Computer. Post processing of the combinational images is done by the computer in offline. The CT Technology uses back projection process for recreating the images of the scanned object. The reconstructed object with simple projection technique looks blurry and cannot convey the information exactly, hence for better clarity Filtered back projection is done. In this paper we will discuss the various filtering techniques for better reconstruction of object.
Two Ion/Ion Charge Inversion Steps To Form a Doubly Protonated Peptide from a Singly Protonated Peptide in the Gas Phase (2003)

An approach is described to increase the degree of protonation of a polypeptide ion in the gas phase. Sequential charge inversion reactions involving the reactions of oppositely charged ions are used to yield a net increase in ion charge. The approach is illustrated here with the conversion of singly protonated bradykinin to doubly protonated bradykinin. The first step involves conversion of the singly protonated peptide to the singly deprotonated peptide via reactions with multiply charged anions derived from carboxylate-terminated dendrimers. Some of the singly deprotonated peptide was then converted to doubly protonated peptide via reactions with multiply charged cations derived from amino-terminated dendrimers. The overall approach is illustrative of a general strategy for increasing the absolute charge states of large ions in the gas phase.
Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats (2008)

Increased methylglyoxal, AGEs, oxidative stress and reduced eNOS along with structural remodeling of the vessel wall in the aorta and mesenteric artery likely play a role in the pathogenesis of hypertension.
Realising distributed multimedia networking services on DPE (2002)

We present and discuss of the networking architecture model and its realization on DPE for the flexible management and rapid introduction of services. This provides various multimedia services over a new networking environment based on concept of TINA on high speed transport network. In the proposed architecture, the applications are deployed through units of software such as managers, agents and servers. Each manager provides a layered view, enabling the effective management and control of the multimedia network resources and services. This paper also propose a naming structure by using directory service system for the flexible management of user and session profiles, and the effective control model of multimedia logical device objects that uses stream process approach. The platform of our model is implemented on distributed processing environment software, ANSAware. In order for provision various services to users and effective management of service introduction, this architecture presents ad hoc service manager such as VOD manager and CSCW manager.
Real-Time PCR Can Rapidly Detect Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Directly From Positive Blood Culture Bottles (2005)

We developed, validated, and implemented real-time polymerase chain reaction (PCR) detection of the femA gene for Staphylococcus aureus and the mecA gene for methicillin resistance directly from BACTEC (Becton Dickinson, Sparks, MD) blood culture bottles showing gram-positive cocci in clusters. For the 332 positive blood cultures tested, the assay had 100% sensitivity and specificity for identifying methicillin-susceptible (n=28) and methicillin-resistant (n=28) S aureus, and overall was 98% sensitive and 94% specific, with 3 uninterpretable test results when identification of coagulase-negative staphylococci was included. PCR detection yields rapid (2-3 hours) results and accurate identification of S aureus directly from signal-positive blood culture bottle samples.
Pioglitazone and Rosiglitazone Have Different Effects on Serum Lipoprotein Particle Concentrations and Sizes in Patients With Type 2 Diabetes and Dyslipidemia (2007)

PIO and ROSI treatments have different effects on serum lipoprotein subclass particle concentrations and sizes in patients with type 2 diabetes and dyslipidemia.
Gasdermins and their role in immunity and inflammation (2019)

The gasdermins are a family of pore-forming proteins recently implicated in the immune response. One of these proteins, gasdermin D (GSDMD), has been identified as the executioner of pyroptosis, an inflammatory form of lytic cell death that is induced upon formation of caspase-1-activating inflammasomes. The related proteins GSDME and GSDMA have also been implicated in autoimmune diseases and certain cancers. Most gasdermin proteins are believed to have pore-forming capabilities. The best-studied member, GSDMD, controls the release of the proinflammatory cytokines IL-1ß and IL-18 and pyroptotic cell death. Because of its potential as a driver of inflammation in septic shock and autoimmune diseases, GSDMD represents an attractive drug target. In this review, we discuss the gasdermin proteins with particular emphasis on GSDMD and its mechanism of action and biological significance.
Synthesis and antimicrobial activity of some novel furyl and benzimidazole substituted benzyl ethers (2007)

Abstract magnified image In this study, a series of novel furyl and benzimidazole substituted benzyl ethers were synthesized and evaluated for antibacterial and antifungal activities against S. aureus , Methicillin resistant S. aureus (MRSA), E. coli, C. albicans and C. krusei. Compound 6f and 6h exhibited the most potent anti‐bacterial activity with lowest MIC values of 3.12 μg/mL against S aureus and MRSA , respectively.
X-ray photoemission analysis and electrical contact properties of NF3 plasma cleaned Si surfaces (1992)

The removal of native silicon oxide on &lt;100≳ silicon with an electron cyclotron resonance (ECR) excited NF3 plasma is demonstrated. In situ x-ray photoemission spectroscopy verifies removal of the oxide and shows that a residue remains on the surface after exposure to the plasma. The residue is about 1.2 nm thick with the approximate formula Si6F8ON2 when analyzed with a uniform overlayer model. X-ray photoemission spectra of the residue show fluorine and oxygen in at least two different bonding states and a unique nitrogen having a diamagnetic bond. Chemical bonding in the residue is ascribed to Fx-Si, Fx-Si-O, Si-O-Si, and N2-O-Si species, where x=1, 2, and 3. A distinct high-energy peak is identified in the quasicore level F 2s transition that is attributed to a small amount of interstitial fluorine having diffused into the silicon lattice. The residue is stable at room temperature in both vacuum and under hydrogen, but when exposed to room ambient, it and the substrate appear to oxidize accounting for a loss of both fluorine and nitrogen. Heating the residue to 640 °C in vacuum causes a significant loss of fluorine and nitrogen also. A possible mechanism accounting for the formation of the residue is proposed assuming that there is a difference in the decay time of the atomic species in the plasma. The ECR cleaning process is integrated into a sputtered TiN/Ti metallization sequence to show the effect of in situ chemical and physical plasma cleaning methods on the electrical contact properties of devices with submicron dimensions and high-aspect ratios. The specific contact resistance of Ti to n+-polycrystalline Si and to TiSi2/n+-, p+-&lt;100≳ Si is found comparable to that achieved with an ECR excited Ar plasma cleaning where a surface residue is not produced.