gebhart/patrepeval huggingface dataset:
Functional Interaction between Acyl-CoA Synthetase 4, Lipooxygenases and Cyclooxygenase-2 in the Aggressive Phenotype of Breast Cancer Cells (2010)

The acyl-CoA synthetase 4 (ACSL4) is increased in breast cancer, colon and hepatocellular carcinoma. ACSL4 mainly esterifies arachidonic acid (AA) into arachidonoyl-CoA, reducing free AA intracellular levels, which is in contradiction with the need for AA metabolites in tumorigenesis. Therefore, the causal role of ACSL4 is still not established. This study was undertaken to determine the role of ACSL4 in AA metabolic pathway in breast cancer cells. The first novel finding is that ACSL4 regulates the expression of cyclooxygenase-2 (COX-2) and the production of prostaglandin in MDA-MB-231 cells. We also found that ACSL4 is significantly up-regulated in the highly aggressive MDA-MB-231 breast cancer cells. In terms of its overexpression and inhibition, ACSL4 plays a causal role in the control of the aggressive phenotype. These results were confirmed by the increase in the aggressive behaviour of MCF-7 cells stably transfected with a Tet-off ACSL4 vector. Concomitantly, another significant finding was that intramitochondrial AA levels are significantly higher in the aggressive cells. Thus, the esterification of AA by ACSL4 compartmentalizes the release of AA in mitochondria, a mechanism that serves to drive the specific lipooxygenase metabolization of the fatty acid. To our knowledge, this is the first report that ACSL4 expression controls both lipooxygenase and cyclooxygenase metabolism of AA. Thus, this functional interaction represents an integrated system that regulates the proliferating and metastatic potential of cancer cells. Therefore, the development of combinatory therapies that profit from the ACSL4, lipooxygenase and COX-2 synergistic action may allow for lower medication doses and avoidance of side effects.
“Aφηíοη (1853)

Journal Article “Aφηíοη Get access A. A. D. A. A. D. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s1-VII, Issue 166, 1 January 1853, Page 24, https://doi.org/10.1093/nq/s1-VII.166.24c Published: 01 January 1853
How To Approximate Effects of Geomechanics in Conventional Reservoir Simulation (2005)

Abstract Geomechanics is often represented in conventional reservoir simulators by pressure dependent treatment of porosity and/or permeability. The paper gives a systematic treatment of the subject and shows different methods for pressure-dependent approximations. Although there is no single method that would provide the best approximation under all circumstances, reasonable approximations exist in several situations. For porosity coupling, the primary factor is the type of deformation. Accurate approximations are given for the cases of uniform depletion with different deformation assumptions. For permeability coupling, new methods have been developed and tested against coupled simulations. The results show clearly that large errors can result from simple approaches, in estimating both reservoir pressure decline and well productivity/injectivity.
Sex Determination by PCR Analysis of the X-Y Amelogenin Gene (2003)

PCR-based sex determination was first accomplished by amplifying multiple-copy sequences in the Y-chromosomal DYZ1 locus (,). These methods are quite sensitive (amplifiable from trace samples) due to the multiplicity, but it is impossible to tell whether the template DNA is from a female or whether the analysis has ended in failure when no fragment is amplified by PCR. Simultaneous amplification of X- and Y-chromosomal genes is thus necessary for a reliable sex test, in which the X-specific product may act as an internal control for PCR. From this point of view, centromeric alphoid repeats on the X and Y chromosomes have been amplified separately () or in the same reaction mixture () using two pairs of primers. These methods are also sensitive. However, a difference in the copy numbers of the repeated sequences (i.e., 5000 and 100 copies in X and Y centromeres, respectively) is likely to cause a difference in the sensitivity of PCR amplification so that the X product does not act strictly as an internal control. Sex determination by PCR analysis of X-Y homologous genes is thus most trustworthy, because X and Y sequences are of equal (single) copy number and because they can be amplified using one set of primers.
The Effect of Iron Content on the Atomic Structure of Alkali Silicate Glasses using Solid-state NMR Spectroscopy (2011)

철을 포함한 비정질 규산염 용융체의 원자 구조 규명은 지표 환경의 화성활동 및 맨틀 심부의 초저속도층의 속도구조에 이르는 광범위한 지질과정의 미시적인 원인에 대한 단서를 제공한다. 본 연구에서는 철을 포함한 비정질 규산염의 원자 구조 규명에 가장 적합한 고상 핵자기공명분광분석(NMR)을 이용하여 최대 16.07 wt%의 <TEX>$Fe_2O_3$</TEX>가 포함된 비정질 알칼리 규산염(iron-bearing alkali silicate glasses)의 철의 함량 변화가 원자구조에 미치는 영향을 규명하였다. <TEX>$^{29}Si$</TEX> 스핀-격자 완화시간(<TEX>$T_1$</TEX>)을 측정한 결과, 철의 함량에 따라 스핀-격자 완화시간이 짧아지는데 이는 철이 가지고 있는 홀전자(unpaired electron)와 핵 스핀(nuclear spin)간의 상호작용으로부터 기인한다. <TEX>$^{29}Si$</TEX> MAS NMR 실험 결과, 철이 포함되지 않은 시료의 경우 <TEX>$Q^2$</TEX>, <TEX>$Q^3$</TEX> 그리고 <TEX>$Q^4$</TEX>의 환경을 지시하는 피크가 분리됨에 반하여, 철이 포함된 시료의 경우 NMR 신호의 급격한 감소와 피크 폭이 넓어짐으로써 각각의 규소 환경이 거의 분리되지 않았다. 그러나 철의 함량에 따라 스펙트럼이 넓어지고 화학적 차폐값(chemical shift)이 높아지는 현상을 확인하였는데, 이는 <TEX>$Q^4$</TEX>의 규소 환경을 나타내는 방향으로서 철 주변의 <TEX>$Q^n$</TEX>이 불균질하게 분포하고 있음을 지시한다. <TEX>$^{17}O$</TEX> MAS NMR 실험에서도 철이 포함되지 않은 시료에서는 연결산소(Si-O-Si)와 비연결산소(Na-O-Si)가 부분적으로 분리되지만, 철의 함량이 증가하면서 각각의 산소 환경이 거의 분리되지 않는다. 이러한 연구결과는 고상 핵자기공명분광분석이 철을 포함한 비정질 규산염의 상세한 구조 연구에 효과적인 도구임을 지시한다. The study on the atomic structure of iron-bearing silicate glasses has significant geological implications for both diverse igneous processes on Earth surface and ultra-low velocity zones at the core-mantle boundary. Here, we report experimental results on the effect of iron content on the atomic structure in iron-bearing alkali silicate glasses (<TEX>$Na_2O-Fe_2O_3-SiO_2$</TEX> glasses, up to 16.07 wt% <TEX>$Fe_2O_3$</TEX>) using <TEX>$^{29}Si$</TEX> and <TEX>$^{17}O$</TEX> solid-state NMR spectroscopy. <TEX>$^{29}Si$</TEX> spin-lattice (<TEX>$T_1$</TEX>) relaxation time for the glasses decreases with increasing iron content due to an enhanced interaction between nuclear spin and unpaired electron in iron. <TEX>$^{29}Si$</TEX> MAS NMR spectra for the glasses show a decrease in signal intensity and an increase in peak width with increasing iron content. However, the heterogeneous peak broa-dening in <TEX>$^{29}Si$</TEX> MAS NMR spectra suggests the heterogeneous distribution of <TEX>$Q^n$</TEX> species around iron in iron-bearing silicate glasses. While nonbridging oxygen (<TEX>$Na-O-Si$</TEX>) and bridging oxygen (Si-O-Si) peaks are partially resolved in <TEX>$^{17}O$</TEX> MAS NMR spectrum for iron-free silicate glass, it is difficult to distinguish the oxygen clusters in iron-bearing silicate glass. The Lorentzian peak shape for <TEX>$^{29}Si$</TEX> and <TEX>$^{17}O$</TEX> MAS NMR spectra may reflect life-time broadening due to spin-electron interaction. These results demonstrate that solid-state NMR can be an effective probe of the detailed structure in iron-bearing silicate glasses.
Season Long Horn Fly Control with an Insecticide-Impregnated Ear Tag12 (1979)

Polyvinyl chloride ear tags impregnated with fenvalerate (a synthetic pyrethroid) eliminated Haematobia irritans (L.) within 24 h and protected cattle from reinfestation for 20 wk.
Structure and selectivity trends in crystalline urea-functionalised anion-binding capsules (2011)

A tripodal trisurea receptor (L1) persistently self-assembles with various divalent oxoanion salts M n X (M = Na, K, Mg, Ca, Cd; X = SO4 2 − , SO3 2 − , SeO4 2 − , CrO4 2 − ) into isomorphous series of crystalline frameworks in three different compositions: MX(L1)2(H2O)6 (M = Mg, Ca, Cd) (1), Na2X(L1)2(H2O)4 (2) and K2X(L1)2(H2O)2 (3). Single-crystal X-ray structural analysis revealed that all three series of structures adopt a NaCl-type topology, consisting of alternating anionic X(L1)2 2 − capsules and M(H2O)6 2+, Na2(H2O)4 2+ or K2(H2O)2 2+ hydrated cations. The capsules provide a complementary environment to tetrahedral oxoanions via 12 hydrogen bonds from six urea groups lining the cavities of the capsules. The persistent formation of the capsules facilitated the investigation of structural trends and structure–selectivity relationships across series 1–3. First, it was found that the size of the capsules is relatively unresponsive to the change in the encapsulated anion, resulting in good shape and size recognition in the separation of anions by competitive crystallisations. Second, it was found that the size of the capsules varies linearly with the size of the external cation, which provides a way for tuning the anion encapsulation selectivity. However, no straightforward dependence was found between the size of the capsules and the relative selectivity for different-sized tetrahedral oxoanions in competitive crystallisations.
The Mysore Population Study (1964)

G. G. Holzer Jerzy — Podstawy analizy demograficznej (Bases de l'analyse démographique). In: Population, 19ᵉ année, n°1, 1964. p. 151.
Use of an Anti‐Idiotypic Monoclonal Antibody in Studying Amyloidogenic Light Chains in Cells, Urine and Fibrils: Pathophysiology and Clinical Implications (1992)

A monoclonal anti-idiotype antibody (IgG1k MoAb 3B11D4) raised against the amyloidogenic DEP lambda chain dimer binds a conformational idiotope also present on the monoclonal DEP IgA immunoglobulin. MoAb 3B11D4 does not recognize the reduced and alkylated lambda chain monomers, nor the 15-17-kDa fibrillar light chain fragments which have the same N-terminal sequence of the urinary light chains. The lack of about 70 amino acid residues of the C terminal of the protein prevents the formation of the self-limiting dimer and may facilitate the deposition of the fragments into amyloid fibrils. MoAb 3B11D4 recognizes the plasma cell clone in bone marrow and 9% of circulating B lymphocytes. Panning experiments demonstrate that this antibody has the capability to selectively eliminate the idiotype positive cells from peripheral blood. Antibodies with these characteristics could become a useful tool for better understanding the pathogenesis of the disease and for new therapeutic options.
The Relationship Between Tensile Strength and Shear Strength in Composite Materials Subjected to High Strain Rates (1988)

This paper contributes to understand the dynamic behavior of a woven carbon/epoxy composite subjected to tensile and shear impact loading in the orthogonal direction by using the tensile and torsional split-Hopkinson bars, respectively. The influences of the equivalent strain rates on the tensile and shear yield stress and strength are found. The yield stress ratio and strength ratio between tensile and shear loading on this composite are compared at a range of the equivalent strain rates from 500 s−1 to 3000 s−1. The relationship between the strain rates and these ratios are established. The failure mechanism is analyzed by microscope observation on the rupture surface of the specimens.
COMPARATIVE STUDY OF THE CHIRAL RESOLUTION OF β-BLOCKERS ON CELLULOSE TRIS (3,5-DIMETHYL-PHENYLCARBAMATE) PHASES IN NORMAL AND REVERSED PHASE MODES (2001)

The chiral separation of β-blockers on cellulose tris (3,5-dimethylphenylcarbamate) columns is described. The separation power of a Chiracel OD normal phase column, a Chiracel OD-RH reversed phase column, and a Chiracel ODRH reversed phase narrow-bore column were compared. Hexane–2-propanol–diethylamine mixtures were used as mobile phase in the normal phase mode and sodium perchlorate buffer containing different amounts of acetonitrile in the reversed phase mode. Sixteen μ-blockers were resolved under normal phase conditions and eleven under reversed phase conditions. The values of α and Rs on normal phase column ranged from 4.46 to 1.10 and 10.04 to 0.97, respectively. The values of α and Rs on reversed phase columns varied from 4.04 to 1.04 and 3.98 to 0.40(on normal bore column) and 4.36 to 1.06 and 2.26 to 0.40(on narrow bore column).
AN EFFICIENT PROCESS FOR THE SYNTHESIS OF CYCLIC HPMPC (2001)

1-[((S)-2-Hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine (cyclic HPMPC) was readily synthesized in gram to multi-kilogram quantities by treating a DMF suspension of HPMPC with four molar equivalents of ethyl chloroformate. This dehydrative intramolecular cyclization process typically afforded cHPMPC in 94% isolated yield and high purity. Benign by-products and solvents were easily removed.
Delivering diagnostic solutions with COTS expert systems; a case study (1999)

More and more organizations are realizing the tremendous cost involved in the maintenance of increasingly complex equipment. Developing diagnostic solutions in-house is highly challenging and very expensive task and the only way to support the development is to re-use tools in many different projects. In recent years, COTS solutions have appeared and proved their mettle in actual use. Serviceability of equipment is crucial to the performance and readiness of the whole organization, which means that downtime must be minimal at all times. In order to shorten the equipment downtime, two conditions most be met. First, the system under test most be testable enough to give the service technicians all the information needed to quickly and accurately diagnose faults, or to determine that the equipment is fully operational by passing all acceptance tests. All of these test activities must be available for easy access, operation and interpretation, often under difficult field conditions and time pressures. Second, the service technician must have enough experience and knowledge to use the information supplied by the different test tools, whether BIT, external test equipment or manual, so that diagnosis is reached efficiently and effectively. Both conditions must be met to provide a good solution for today's service problems. In this paper, we describe the implementation of an innovative test solution mounted on the vehicle itself. The solution is based on a COTS test and diagnostics tool that supplies guidance, recommendation and intelligent on-line documentation.
In vivo preservation of steroid specificity in CWR22 xenografts having a mutated androgen receptor (2003)

The mutation of the androgen receptor (H874Y) that occurs in the CWR22 xenograft model of human prostate cancer does not significantly affect in vivo steroid specificity for E(2), P, or F.
MARR-ALOHA: A mobility adaptive variety of RR-ALOHA for vehicular ad-hoc networks (2012)

Although many Distributed Time-scheduling MAC algorithms are under evaluation for vehicular Ad-hoc networks (VANET), they are still not fully applicable for VANET with requirements of transmission reliability and efficiency. In this paper, a mobility adaptive variety of RR-ALOHA is proposed to adapt to the diversity of node density and contention severity in VANET. By introducing CSMA into slot and making full use of 3-hops channel state, the proposed schema outperforms RR-ALOHA in several aspects. NS-2 simulation results show that the novel protocol improves the speed of Basic Channel (BCH) reservation as well as the quality of slot allocation.
Spinal Metastasis of Glioblastoma Multiforme (2010)

Spinal metastases should be commonly suspected in patients with a history of intracranial GBM who complain about symptoms not explained by the primary lesion.Glioblastoma multiforme (GBM) was first described by Rudolph Virchow in 1863 and represents the most common and most malignant tumor of the cerebral hemispheres, usually arising between the ages of 40 and 60 years. The incidence in Europe and North America is 2 to 3 cases/100,000 per year, and 75% of the patients die within 18 months after diagnosis. It is an infiltrating malignancy that recurs locally and it may spread along compact fiber pathways such as corpus callosum, optic irradiation, anterior commisure, and fornix or via cerebrospinal fluid (CSF) pathways. However, when GBM is under apparent control, spinal metastases are clinically rarely detected. Although involvement of the spinal cord (SC) has been noted with increasing frequency in recent years, literature provides only a few well documented cases.
Dysferlin, Annexin A1, and Mitsugumin 53 Are Upregulated in Muscular Dystrophy and Localize to Longitudinal Tubules of the T-System With Stretch (2011)

Mutations in dysferlin cause an inherited muscular dystrophy because of defective membrane repair. Three interacting partners of dysferlin are also implicated in membrane resealing: caveolin-3 (in limb girdle muscular dystrophy type 1C), annexin A1, and the newly identified protein mitsugumin 53 (MG53). Mitsugumin 53 accumulates at sites of membrane damage, and MG53-knockout mice display a progressive muscular dystrophy. This study explored the expression and localization of MG53 in human skeletal muscle, how membrane repair proteins are modulated in various forms of muscular dystrophy, and whether MG53 is a primary cause of human muscle disease. Mitsugumin 53 showed variable sarcolemmal and/or cytoplasmic immunolabeling in control human muscle and elevated levels in dystrophic patients. No pathogenic MG53 mutations were identified in 50 muscular dystrophy patients, suggesting that MG53 is unlikely to be a common cause of muscular dystrophy in Australia. Western blot analysis confirmed upregulation of MG53, as well as of dysferlin, annexin A1, and caveolin-3 to different degrees, in different muscular dystrophies. Importantly, MG53, annexin A1, and dysferlin localize to the t-tubule network and show enriched labeling at longitudinal tubules of the t-system in overstretch. Our results suggest that longitudinal tubules of the t-system may represent sites of physiological membrane damage targeted by this membrane repair complex.
Robust re-authentication and key exchange protocol for IEEE 802.11 wireless LANs (2002)

We introduce a robust re-authentication and key exchange protocol for IEEE 802.11 wireless LANs. Based on an authentication protocol that we have previously published, we introduce a low computational complexity re-authentication and key exchange procedure that provides enhanced robustness in face of cryptographic attacks. This procedure accounts for the wireless media limitations, e.g., limited bandwidth and noise. We introduce the re-authentication period (RP) that reflects the frequency that the re-authentication procedure should be executed. We provide the user with suitable guidelines that will help in the determination of the re-authentication period.
A role in cell-binding for the C-terminus of pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae (1994)

Cell binding of pneumolysin to target cells is an important step in the lysis of cells by this toxin. We sought to locate the cell-binding region of pneumolysin. Deletion of the six C-terminal amino acids decreased cell-binding activity by 98%. Furthermore, mutagenesis of an amino acid near the C-terminus decreased the cell-binding activity of full-length pneumolysin by 90%. The C-terminus of pneumolysin has an important role in cell-binding activity.
Studies of blood group substances. I. Caprine precipitating antisera to human Le-a and Le-b blood group substances. (1966)

Summary 1 )Precipitating antisera to unmodified human Le a and Le b blood group substance were obtained by immunization of goats. 2 )The specificities of these antisera, as defined by inhibition with oligosaccharides of known structure and activity, are very similar to human isoantibodies.
ChemInform Abstract: Fused Imidazole Systems: Synthesis and Studies on Chemical Structure‐ Antiinflammatory Activity Relationships. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Augmented Reality Visualization During Laparoscopic Radical Prostatectomy (2011)

Feasibility of the navigation system was shown in the first in-vivo application. TRUS information could be superimposed via AR in real time. To show the benefit for the patient, results obtained from a larger number of trials are needed.
Part-based multiple-person tracking with partial occlusion handling (2012)

Single camera-based multiple-person tracking is often hindered by difficulties such as occlusion and changes in appearance. In this paper, we address such problems by proposing a robust part-based tracking-by-detection framework. Human detection using part models has become quite popular, yet its extension in tracking has not been fully explored. Our approach learns part-based person-specific SVM classifiers which capture the articulations of the human bodies in dynamically changing appearance and background. With the part-based model, our approach is able to handle partial occlusions in both the detection and the tracking stages. In the detection stage, we select the subset of parts which maximizes the probability of detection, which significantly improves the detection performance in crowded scenes. In the tracking stage, we dynamically handle occlusions by distributing the score of the learned person classifier among its corresponding parts, which allows us to detect and predict partial occlusions, and prevent the performance of the classifiers from being degraded. Extensive experiments using the proposed method on several challenging sequences demonstrate state-of-the-art performance in multiple-people tracking.
Intracavity sensing via compliance voltage in an external cavity quantum cascade laser (2012)

We demonstrate a technique for gas phase spectroscopy and sensing by detecting changes in compliance voltage of an external cavity quantum cascade laser due to intracavity absorption. The technique is characterized and used to measure the absorption spectrum of water vapor and Freon-134a.
Ionic elastomer based on carboxylated nitrile rubber: infrared spectral analysis (2000)

Carboxylated nitrile rubber (XNBR) neutralized by metal oxide forms an ionic elastomer (ionomer) due to formation of ionic clusters by the metal carboxylated salt. Cluster formation in carboxylated nitrile rubber by metal oxide, mainly zinc oxide (ZnO), has been studied by infrared analyses. Two modes of plasticization, ie plasticization of the hydrocarbon-rich phase and plasicization of the ionic domains (hard phase), have also been analysed by infrared studies. Results reveal that the cluster formation is stabilized at higher loading of metal oxide with hexacoordinate salt formation and depends on the type of metal oxide. Spectral studies also reveal that a non-polar plasticizer such as dioctyl phthalate does not affect the characteristic bands of ionic cluster, but polar plasticizers such as dimethylsulfoxide and ammonia solvate the ionic cluster, causing the disappearance of the band corresponding to the hexacoordinated carboxylate salt. Infrared spectral analysis of the ionomer based on carboxylated nitrile rubber (XNBR) further confirms the earlier claims that the profound change in physical properties of the polymer is due to the presence of physical crosslinks generated by ionic clusters. © 2000 Society of Chemical Industry
Absorption of apomorphine by various routes in parkinsonism (1991)

We wanted to determine the absorption and clinical effect of sublingual (SL) and transdermal apomorphine in parkinsonism. Patients received single SL apomorphine doses (N = 7) and the absorption was compared with parenteral (N = 5) and oral (N = 4) doses. One patient received a transdermal dose of apomorphine. The relative bioavailability of SL apomorphine ranged from 10 to 22% of a parenteral apomorphine dose. Oral apomorphine was less than 4% bioavailable, and the transdermal dose did not produce detectable plasma levels. Three patients with motor fluctuations responded to SL apomorphine, with a latency to effect of 20-40 min and a duration of effect of 15-100 min. One patient used SL apomorphine as an adjunct with levodopa, and during 1 month reported a large decrease in "off" periods. We conclude that apomorphine is effectively absorbed by the sublingual route.