gebhart/patrepeval huggingface dataset:
Digital watermarking of color image (2006)

An analytic method of embedding color watermarks into the color images is proposed. The original image is color image of size 480X640, and the watermark image is 24-bit-gray scale image of size 120X160. The quality variations of the embedded image and extracted watermark are analyzed. From the experimental results they appear that the quality of embedded image varies with the quantization index (QI). They also show that the quality of extracted watermark is dependent on the gray-level of the original image. The relationship between the gray-level and the noise of embedded image has been quantitatively analyzed. The digital quantization method is also important to decrease the noise of embedding image and the error of extracting watermark.
Efficacy and safety of dulaglutide in the treatment of type 2 diabetes: a comprehensive review of the dulaglutide clinical data focusing on the AWARD phase 3 clinical trial program (2016)

Dulaglutide (DU) is a once weekly glucagon-like peptide-1 receptor agonist (GLP-1 RA) approved for the treatment of type 2 diabetes mellitus (T2DM). Glycaemic efficacy and safety characteristics of dulaglutide have been assessed in six Phase 3 studies in the AWARD program. The objective of this review article is to summarize these results from the six completed AWARD studies. At the primary endpoint, in five of the six studies, once weekly dulaglutide 1.5 mg was superior to the active comparator [exenatide, insulin glargine (two studies), metformin, and sitagliptin], with a greater proportion of patients reaching glycated hemoglobin A1c (HbA1c) targets of <7.0% (53.0 mmol/mol) and ≤6.5% (47.5 mmol/mol). Dulaglutide 1.5 mg was non-inferior to liraglutide in AWARD-6. Once weekly dulaglutide 0.75 mg was evaluated in five of these trials and demonstrated superiority to the active comparator in four of five AWARD studies (exenatide, glargine, metformin, and sitagliptin), and non-inferiority to glargine in the AWARD-2 study. Similar to other GLP-1 receptor agonists, treatment with dulaglutide was associated with weight loss or attenuation of weight gain and low rates of hypoglycaemia when used alone or with non-insulin-secretagogue therapy. The most frequently reported adverse events were gastrointestinal, including nausea, vomiting, and diarrhea. The incidence of dulaglutide antidrug antibody formation was 1-2.8% with rare injection site reactions. In conclusion, dulaglutide is an effective treatment for T2DM and has an acceptable tolerability and safety profile. Copyright © 2016 John Wiley & Sons, Ltd.
Von Neumann's 29-state cellular automaton: a hardware implementation (2000)

In the early 1950s, John von Neumann designed a cellular automaton implementing a universal self-replicating structure. More than 40 years after his death, the first hardware implementation of von Neumann's transition rule is presented. Unfortunately, this implementation only allows small systems to be realized, and not the complete structure, which would require 100000-200000 cells, according to some estimations. A logic circuit which implements the transition rule and represents a single cell of the array has been developed. The applications of this implementation lie mainly in the pedagogical domain. It can be used as a demonstration tool for courses on cellular automata.
Distinct infrared spectroscopic patterns of human basal cell carcinoma of the skin. (1993)

Infrared spectroscopy combined with high pressure (pressure-tuning infrared spectroscopy) was applied to the study of paired sections of basal cell carcinomas (BCC) and normal skin from ten patients. Atmospheric pressure IR spectra from BCC were dramatically different from those from the corresponding normal skin. Compared to their normal controls, BCCs displayed increased hydrogen bonding of the phosphodiester group of nucleic acids, decreased hydrogen bonding of the C--OH groups of proteins, increased intensity of the band at 972 cm-1, a decreased intensity ratio between the CH3 stretching and CH2 stretching bands, and accumulation of unidentified carbohydrates. Some of these changes are shared by all human epithelial malignancies studied to date, while some others appear as yet unique to basal cell carcinoma. The diagnostic value of infrared spectroscopy in BCC remains to be determined.
Utilization of time-kill kinetic methodologies for assessing the bactericidal activities of ampicillin and bismuth, alone and in combination, against Helicobacter pylori in stationary and logarithmic growth phases (1995)

Assessment of in vitro susceptibility testing of Helicobacter pylori is difficult because of the fastidious, slowly growing nature of this microorganism. The high rate of relapse observed clinically and a possible subpopulation of cells that are not actively replicating suggest the potential need for bactericidal therapy in order to eradicate H. pylori. We used modified time-kill kinetic methodology in order to evaluate the bactericidal activities of ampicillin and bismuth, alone and in combination, against three strains of H. pylori in both a stationary (slow) growth phase and a logarithmic (rapid) growth phase. We found that ampicillin produced a decrease in CFU per milliliter (2 to 4 log10 units) for three strains of H. pylori when tested in logarithmic growth phases but was less inhibitory (< 1-log10-unit decrease in CFU per milliliter) when tested in a stationary growth phase. In contrast, bismuth, when tested in a logarithmic growth phase, produced little inhibitory effect, as the CFU for all strains tested increased above the inoculum. However, when tested in a stationary growth phase, bismuth produced a decrease in CFU per milliliter of < 1 to > 3 log10 units). The activities of these two agents when combined mimicked the activity of the most active drug alone for that growth phase. We conclude that the clinical use of ampicillin combined with bismuth has been more effective than that of either agent used alone because ampicillin targets replicating cells, whereas bismuth targets cells that are not actively replicating.
Estimating Magnitude and Duration of Incident Delays (1997)

Traffic congestion is a major operational problem on urban freeways. In the case of recurring congestion, travelers can plan their trips according to the expected occurrence and severity of recurring congestion. However, nonrecurring congestion cannot be managed without real-time prediction. Evaluating the efficiency of intelligent transportation systems (ITS) technologies in reducing incident effects requires developing models that can accurately predict incident duration along with the magnitude of nonrecurring congestion. This paper provides two statistical models for estimating incident delay and a model for predicting incident duration. The incident delay models showed that up to 85% of variation in incident delay can be explained by incident duration, number of lanes affected, number of vehicles involved, and traffic demand before the incident. The incident duration prediction model showed that 81% of variation in incident duration can be predicted by number of lanes affected, number of vehicles involved, truck involvement, time of day, police response time, and weather condition. These findings have implications for on-line applications within the context of advanced traveler information systems (ATIS).
Recent Advances in Facial Appearance Capture (2015)

Abstract Facial appearance capture is now firmly established within academic research and used extensively across various application domains, perhaps most prominently in the entertainment industry through the design of virtual characters in video games and films. While significant progress has occurred over the last two decades, no single survey currently exists that discusses the similarities, differences, and practical considerations of the available appearance capture techniques as applied to human faces. A central difficulty of facial appearance capture is the way light interacts with skin—which has a complex multi‐layered structure—and the interactions that occur below the skin surface can, by definition, only be observed indirectly. In this report, we distinguish between two broad strategies for dealing with this complexity. “Image‐based methods” try to exhaustively capture the exact face appearance under different lighting and viewing conditions, and then render the face through weighted image combinations. “Parametric methods” instead fit the captured reflectance data to some parametric appearance model used during rendering, allowing for a more lightweight and flexible representation but at the cost of potentially increased rendering complexity or inexact reproduction. The goal of this report is to provide an overview that can guide practitioners and researchers in assessing the tradeoffs between current approaches and identifying directions for future advances in facial appearance capture.
Belief Propagation for Distributed Downlink Beamforming in Cooperative MIMO Cellular Networks (2011)

We propose a new graphical model approach to cooperative multiple-input multiple-output (MIMO) cellular networks. The objective is to optimize downlink transmit beamforming at each BS in order to maximize the sum throughput over the entire network. While ideal centralized beamforming requires full channel state information (CSI) sharing among all BSs in the network and huge computational complexity for combinatorial optimization, the proposed graphical model enables distributed beamforming which requires only local CSI sharing between neighboring BSs and efficiently solves the optimization problem in a distributed manner. As distributed solvers for this problem, we derive message-passing algorithms which can be implemented with polynomial-time computational complexity. Furthermore, we make a slight approximation on the objective function to derive a simpler graphical model, providing further complexity saving. Simulation results indicate that the proposed distributed downlink beamforming achieves average cell throughput typically within just 2% of ideal centralized beamforming.
Positive clinical impact of low tidal volume strategy* (2005)

Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Section of Critical Care Medicine, Cooper University Hospital, Camden, NJ
Modeling of the field transfer through thick dielectric lines: use in linewidth measurement (1991)

A numerical method for calculating the optical image of a thick line object is presented. It consists of slicing (fictitiously) the object and of analyzing the propagation through each elementary slice. The method is first developed for coherent light and then generalized for partially coherent illumination. Some results are compared with other simulations and with experiments.
[3-Amino-2H-1,2,4-benzothiadiazine-1,1-dioxides with antihypertensive and possibly diabetogenic activity (author's transl)]. (1981)

By reaction of dialkylaminoalkylamines or omega-amino-alkylethers with 2H-1,2,4-benzothiadiazine-1,1-dioxides bearing a group in the 3-position labile towards nucleophilic substitution (Cl, CH3S, CH3CO2), the corresponding 3-substituted amino-2H-1,2,4-benzothiadiazine-1,1-dioxides are obtained. A series of these compounds exerts an antihypertensive effect in the renally hypertonic rat after oral administration and in the "two-kidney hypertensive dog" after parenteral administration. Two compounds (1 and 4) were studied thoroughly in comparison to diazoxide (16) and the known piperazino compound (17). At 10 mg/kg in the rat, diazoxide causes a marked reduction of water and electrolyte excretion but at this dosage 1 and 4 are neither diuretic nor antidiuretic. In the hyperglycaemia test on normal rats at a dosage 30--100 times that required for an antihypertensive effect, 1 and 4 show after 300 mg/kg no hyperglycaemic effect and after 1000 mg/kg p.o. a very weak one. 17 has a weak hyperglycaemic effect at 300 mg/kg diazoxide a strong one. However, intensive glucose loading studies on diabetic rats (reduced glucose-tolerance) and on metabolically healthy rats with glucose loading showed that compounds 1 and 4 as well as the piperazine derivative 17 inhibit insulin release, albeit in higher doses than does diazoxide. In animals with insulin resistance a diabetic metabolic condition occurs with high blood-sugar levels. Owing to this possible diabetogenic activity, testing and application of 1, 4 and the known 7-chloro-3-(4-methyl-1-piperazinyl)-2H-1,2,4-benzothiadiazine-1,1-dioxide for blood-sugar lowering activity to human volunteers is not considered appropriate.
The SPS algorithm: patching figural continuity and transparency by split-patch search (2004)

This paper describes a novel algorithm for the efficient synthesis of high-quality virtual views from only two input images. The emphasis is on the recovery of continuity of objects boundaries (figural continuity) with faithful synthesis of transparency effects. The contribution of this paper is two-fold: (i) the split-patch search (SPS) technique is introduced for dense stereo which handles transparency effects by assigning multiple disparities to mixed pixels; (ii) an efficient extension of exemplar-based image synthesis to the case of two-camera stereo is proposed. Furthermore, this paper presents an approximate but effective solution to the challenging problem of layer estimation and compositing in the case of small image patches. The effectiveness of the proposed technique is demonstrated on a number of stereo image pairs taken from two camera video-conferencing setups, where the quality of the synthesized talking heads is of paramount importance. Moreover the improvement in the quality of image synthesis is quantified by comparing the output of the SPS algorithm with thirteen ground-truth images.
The Structure of Large and Small Airways in Nonfatal and Fatal Asthma (1993)

Asthma is characterized by excessive airway narrowing and airway wall inflammation. In cases of fatal asthma, increased thickness of the airway wall is observed and may account for excessive airway narrowing when smooth muscle contracts. This study was undertaken to examine airway dimensions in large and small airways in both fatal and nonfatal cases of asthma. Airway wall areas (total, inner, and outer relative to smooth muscle layer), epithelial integrity, smooth muscle shortening, and the areas of smooth muscle, cartilage, and mucous glands were compared in transverse sections of large and small airways of subjects dying of asthma (fatal asthma, n = 11), those dying suddenly of nonrespiratory diseases and having a definite history of asthma (nonfatal asthma, n = 13), and those dying suddenly without any history of respiratory illness (control, n = 11). Airways were grouped by size using the basement membrane perimeter for comparison. All areas were expressed as areas per millimeter of basement membrane. In cartilaginous airways, the cases of fatal asthma had greater (p < 0.05) total wall, inner wall, outer wall, smooth muscle, mucous gland and cartilage areas than did control and nonfatal cases. The inner wall area was greater in the fatal and nonfatal cases than in the control cases (p < 0.05) in the small cartilaginous airways and membranous bronchioles (MB). In small MB (perimeter < 2 mm), the total and outer wall areas were greater (p < 0.05) in cases of fatal and nonfatal asthma than in control cases.(ABSTRACT TRUNCATED AT 250 WORDS)
Preparation of Co–Pt–P thin films by magnetic electrodeposition (2013)

Magnetic fields perpendicular to the electric field were applied during an electrodeposition process to obtain Co–Pt–P thin films from alkaline baths. Effects of different current densities and magnetic intensities on the composition, microstructure and magnetic properties of Co–Pt–P thin films were studied. It was found that the deposition rate and films thickness increased gradually with the increase of the current density and magnetic intensity. Almost all of the deposited films were crystalline and showed Co(002), CoPt(111) peaks. With the increase in the magnetic intensity, the intensity of CoPt(111) peak decreased while the intensity of Co(002) rose gradually. Magnetic fields would induce cobalt growing along (002) orientation. The films were densely covered with typical nodular structure. When the current density increased to 100 A m−2, rougher and agglomerate nodular structures would be formed. Films of smaller grain size and smooth surface could be formed under high magnetic intensity (0·5 T) as a result of impact of magnetic force and MHD effects. Furthermore, higher current density induced larger Magnetisation and lower coercivity. Largest coercivity could be achieved when current density equals to 70 A m−2. With the increase in magnetic intensity, cobalt contents in films increase gradually which lead to the rise on magnetisation.
FGF signalling is required for differentiation-induced cytoskeletal reorganisation and formation of actin-based processes by podocytes (2001)

To examine the potential role of fibroblast growth factor (FGF) signalling during cell differentiation, we used conditionally immortalised podocyte cells isolated from kidneys of Fgf2 mutant and wild-type mice. Wild-type mouse podocyte cells upregulate FGF2 expression when differentiating in culture, as do maturing podocytes in vivo. Differentiating wild-type mouse podocyte cells undergo an epithelial to mesenchymal-like transition, reorganise their actin cytoskeleton and extend actin-based cellular processes; all of these activities are similar to the activity of podocytes in vivo. Molecular analysis of Fgf2 mutant mouse podocyte cells reveals a general disruption of FGF signalling as expression of Fgf7 and Fgf10 are also downregulated. These FGF mutant mouse podocyte cells in culture fail to activate mesenchymal markers and their post-mitotic differentiation is blocked. Furthermore, mutant mouse podocyte cells in culture fail to reorganise their actin cytoskeleton and form actin-based cellular processes. These studies show that FGF signalling is required by cultured podocytes to undergo the epithelial to mesenchymal-like changes necessary for terminal differentiation. Together with other studies, these results point to a general role for FGF signalling in regulating cell differentiation and formation of actin-based cellular processes during morphogenesis.
Growth-Related Glycogen Levels of Human Intestine Carcinoma Cell Lines Grown In Vitro and In Vivo in Nude Mice<xref ref-type="fn" rid="FN2">2</xref> (1980)

The relationship known to exist in vitro between glycogen accumulation and the growth of malignant human intestine epithelial cells was investigated in vivo. The glycogen concentration of 7 human intestine carcinoma cell lines (Caco-2, HT-29, HRT-18, HCT-8R, CO-115, SW-480, and HuTu 80) was measured during cell growth for the in vitro series and during the course of tumor growth for the in vivo series. The glycogen stores were compared for these cells in vitro and after their injection in noninbred Swiss athymic nude mice. The tumors and cultured cells were ranked identically on the basis of glycogen level (Caco-2 > HRT-18 > HT-29 > HCT-8R > CO-115 > SW-480 > HuTu 80). Values for the tumors ranged from 128.8 +/- 10.8 micrograms glycogen/mg protein for Caco-2 tumors down to 2.9 +/- 0.9 micrograms for HuTu 80 tumors; similar values were found for the exponentially growing corresponding cultured cells. The tumor glycogen concentration was independent of the host's nutritional state: Glycogen concentration differed from one type of tumor to another despite its constant level in the liver; fasting did not cause tumor glycogenolysis. By the two experimental approaches, results varied during the growth phases: Stationary phase glycogen concentration increased threefold to fourfold for all cultured cell lines; tumor glycogen concentration, by contrast, was stable throughout the growth period. An inverse relationship was nonetheless found between the rate of tumor growth and tumor glycogen concentration; the highest glycogen content was associated with the slowest growing tumors, and conversely. Apparently, elevated glycogen concentration is regularly associated with decreased cell division rates in vitro and in vivo.
SCDT-38. SAFETY AND EFFICACY OF INTRAVENTRICULAR 131I-LABELED MONOCLONAL ANTIBODY 8H9 TARGETING THE SURFACE GLYCOPROTEIN B7-H3 IN PATIENTS WITH CNS/LM DISEASE (2017)

Tumors metastasizing to the central nervous system (CNS) are associated with significant mortality. We tested the toxicity and dosimetry of intraventricular 131I-labeled monoclonal antibody 8H9 targeting surface glycoprotein B7-H3 in patients with CNS. Tumor B7-H3 expression was assessed by immunohistochemistry. CSF flow was determined by 111Indium-DTPA cisternography. 131 patients received 2 mCi tracer of intra-Ommaya 124I- or 131I-8H9 for nuclear imaging followed by a therapeutic injection (10-80 mCi, dose levels 1-8 in 10 mCi increments for phase I patients; expanded cohort 50 mCi/injection) 131I-8H9. Pharmacokinetics were studied by serial CSF and blood samplings over 48 hours. Dosimetry was based on pharmacokinetics and region of interest analyses on serial PET. Toxicity was defined by the CTCAE v.3.0. 8H9 dosimetry and therapy injections were repeated after 1 month if no serious adverse events or progressive disease ensued. Tumor response was determined by clinical, radiographic, cytologic criteria; overall survival was noted. 129 patients with primary or metastatic CNS tumors received 383 injections [median age 5.4 years (1.2- 53.6 years)] Injections were well tolerated and routinely administered in the outpatient setting. Rare self-limited adverse events included grade 1 or 2 fever, headache, vomiting, biochemical elevations in AST or ALT and 1 injection with grade 3 ALT elevation (dose level 3). Although not a dose limiting toxicity, myelosuppression occurred in patients who had received craniospinal radiation and at dose levels 6 and higher (>60 mCi). Of 93 patients treated for metastatic CNS neuroblastoma, an improved overall survival was noted compared to survival reported with conventional therapies. Interpatient variability for total absorbed dose to the CSF and blood was observed; mean absorbed CSF dose was 104.9 cGy/mCi by CSF sampling, and 2.6 cGy/mCi to the blood. We conclude that intraventricular 131I-8H9 is safe, has favorable dosimetry to CSF, and has clinical utility.
A practical obstacle detection system for autonomous orchard vehicles (2012)

Safe robot navigation in tree fruit orchards requires that the vehicle be capable of robustly navigating between rows of trees and turning from one aisle to another; that the vehicle be dynamically stable, especially when carrying workers; and that the vehicle be able to detect obstacles on its way and adjust its speed accordingly. In this paper we address the latter, in particular the problem of detecting people and apple bins in the aisles between rows. One of our requirements is that the obstacle avoidance subsystem shouldn't add to the robot's hardware cost, so as to keep the acquisition cost to growers as low as possible. Therefore, we confine ourselves to solutions that use only the sensor suite already installed on the robot for navigation-in our case, a laser scanner, low-cost inertial measurement unit, and steering and wheel encoders. Our methodology is based on the classification and clustering of registered 3D points as obstacles. In the current implementation, obstacle avoidance takes in 3D point clouds collected in apple orchards and generates an off-line assessment of obstacle position. Tests conducted at our experimental orchard-like environment in Pittsburgh and an actual apple orchard in Washington state indicate that the method is able to detect people and bins located along the vehicle path. Stretch tests indicate that it is also capable of dealing with objects as small as 15 cm tall as long as they aren't covered by grass, and to detect people crossing the aisles at walking speed.