gebhart/patrepeval huggingface dataset:
Hereditary Angioedema Nationwide Study in Slovenia Reveals Four Novel Mutations in SERPING1 Gene (2013)

Hereditary angioedema (HAE) is a rare autosomal dominant disease characterized by swelling of the face, lips, tongue, larynx, genitalia, or extremities, with abdominal pain caused by intra-abdominal edema. HAE is caused by mutations affecting the C1 inhibitor gene, SERPING1, resulting in low levels of C1 inhibitor (Type I HAE) or normal levels of ineffective C1 inhibitor (Type II HAE). A nationwide survey identified nine unrelated families with HAE in Slovenia, among whom 17 individuals from eight families were recruited for genetic analyses. A diagnosis of HAE was established in the presence of clinical and laboratory criteria (low C1 inhibitor antigenic levels and/or function), followed up by a positive family history. Genetic studies were carried out using PCR and sequencing to detect SERPING1 mutations in promoter, noncoding exon 1, the 7 coding exons, and exon-intron boundaries. Multiplex ligation-dependent probe amplification was performed in order to search for large deletions/duplications in SERPING1 gene. A mutation responsible for HAE was identified in patients from seven families with the disease. In HAE type I families, one previously reported substitution (Gln67Stop, c.265C>T) and four novel mutations were identified. The new mutations included two missense substitutions, Ser128Phe (c.449C>T), and Glu429Lys (c.1351G>A), together with two frameshift mutations, indel (c.49delGinsTT) and deletion (c.593_594delCT). Both families with HAE type II harbored the two well-known substitutions affecting the arginyl residue at the reactive center in exon 8, Arg444Cys (c.1396C>T) and Arg444His (c.1397G>A), respectively. In one patient only the homozygous variant g.566T>C (c.-21T>C) was identified. Our study identified four novel mutations in the Slovenian HAE population, highlighting the heterogeneity of mutations in the SERPING1 gene causing C1 inhibitor deficiency and HAE. In a single patient with HAE a homozygous variant g.566T>C (c.-21T>C) might be responsible for the disease.
Photoplethysmographic logger with contact force and hydrostatic pressure monitoring (2013)

Oxygen saturation is a key parameter for assessing a patient condition. The present work aims to develop a stand-alone pulse oximeter and photoplethysmographic system. In addition, it incorporates a force sensor and a set of accelerometers to measure the contact force and the finger height offset relatively to the heart. Both the design of hardware and the development of firmware are presented. Currently, the system is able to retrieve a stable photoplethysmographic waveform and compute the oxygen saturation in real time. Signals acquired in a healthy subject led to a value of 91.5±1.1%. Both the height offset of the finger and the contact force between the finger and the probe proved to have influence in the photoplethysmographic waveform as well as in the oxygen saturation results.
Organic–inorganic chemical hybrids having shape memory effect (2010)

Vinyltrimethoxysilane (VTMS)-modified silica particles were incorporated into the chain of amorphous polyurethane (PU) by covalent bonds, to synthesize an organic–inorganic hybrid material with an extremely long relaxation time. At 1% silica, the PU–silica chemical hybrids gave over 99% shape fixity and shape recovery with <2% hysteresis during the four thermomechanical cycles. As silica content increases (2, 3%) shape memory performance slightly decreased with repeated cycles. Results were favorably compared with PUs cross-linked by hydroxyl ethylacrylate (HEA) and VTMS, and physical blends with silica particles. The results were interpreted based on the triple effects of silica particles as multifunctional cross-linkers, reinforcing fillers, and relaxation retarders of the polymer chains during loading and unloading.
Estimating and interpreting the instantaneous frequency of a signal. I. Fundamentals (1992)

The concept of instantaneous frequency (IF), its definitions, and the correspondence between the various mathematical models formulated for representation of IF are discussed. The extent to which the IF corresponds to the intuitive expectation of reality is also considered. A historical review of the successive attempts to define the IF is presented. The relationships between the IF and the group-delay, analytic signal, and bandwidth-time (BT) product are explored, as well as the relationship with time-frequency distributions. The notions of monocomponent and multicomponent signals and instantaneous bandwidth are discussed. It is shown that these notions are well described in the context of the theory presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A table masking countermeasure for low-energy secure embedded systems (2006)

Future wireless embedded devices will be increasingly powerful, supporting many more applications, including one of the most crucial, which is security. Although many embedded devices offer more resistance to bus probing attacks due to their compact size, susceptibility to power or electromagnetic analysis attacks must be analyzed. This paper presents a table masking countermeasure to resist differential power analysis (DPA) and differential electromagnetic analysis (DEMA). Real power and EM measurements are used to verify the countermeasure using second- and third-order DPA and DEMA attacks on a popular low-energy embedded ARM processor. Results show that the new table masking countermeasure provides increased security without large overheads of energy dissipation compared with previous countermeasures. With the emergence of security applications personal digital assistants, cellphones, and other embedded devices, low-energy countermeasures for resistance to DPA/DEMA are crucial for supporting future wireless embedded systems
Record Linkage - a Method to Generate an Enriched Dataset for the Study of CPOE Systems on Test Turnaround Time (2008)

Background: One of the major challenges facing health IT planners is accessing the right information for the evaluation of the impact of Computerised Provider Order Entry (CPOE) systems on the delivery of health care. This information usually resides in information systems that are not integrally linked. Record linkage is a method through which records from different but related databases are linked retrospectively. Objective: This paper describes the procedural steps used to link records from different data sources to generate information enriched dataset for the evaluation of the impact of CPOE systems on turn around time (TAT) for tests ordered in the Emergency Department. Methods: Data about patients admitted to a hospital from a NSW Area Health Service before and after the implementation of CPOE systems were extracted from two separate information systems. These were the Emergency Department Information System, and Hospital Laboratory Information System. We linked these datasets using the deterministic linkage method, where Medical Record Number and admission dates were used as linkage variables to identify each admission episode. To ensure the quality of the final dataset, data quality checks using data profiling techniques were performed prior to data linkage separately for each dataset, and validation tests were carried out post linkage. Results: In total 285595 data points with 37 variables were generated from the linkage. This dataset allowed analyses to be conducted to examine the impact of CPOE systems on health delivery indicators such as measures of efficiency (eg. turnaround times for pathology requests), and effectiveness (eg. test volumes and rate redundant tests). Conclusion: This study demonstrated the value of using a standardized record linkage technique in generating a quality dataset with enriched information. Analyses applied to these enriched datasets can provide valuable information to health system planners, clinicians and pathology managers for use in managing and evaluating new CPOE systems.
Spray Adjuvant Effects on Droplet Size Spectra Measured by Three Laser-Based Systems in a High-Speed Wind Tunnel (2008)

Abstract Spray droplet size has long been recognized as the most important variable that aerial applicators can influence to mitigate spray drift from the application site. There are several different technologies that are used by researchers to measure droplet size from spray nozzles. The objective of these studies was to determine the influence of eight spray adjuvants on the droplet size spectrum produced by two nozzles in a high-speed wind tunnel when characterized using three different droplet size measurement systems. The adjuvant, nozzles, and airspeeds used in these studies are commonly used by aerial applicators. Three droplet sizing systems (Malvern laser diffraction, PMS optical array probe, and LaVision laser imaging) were simultaneously operated to measure the spray droplet size spectra for each adjuvant, airspeed, and nozzle combination. Two spray nozzles (a D6-46 nozzle and a D2 straight stream nozzle) were evaluated in a high-speed wind tunnel at airspeeds of 45 and 58 m/sec. There were significant differences in the droplet size spectra produced by the eight spray adjuvants tested. There were also significant differences between the droplet size values reported by the three measurement systems (Malvern, LaVision, and PMS) evaluated; however, there was considerable agreement trendwise. In general, the Malvern reported smaller spray droplet size spectra values than the LaVision, while the PMS system generally reported the largest spray droplet size spectra values. These tests are the first reported studies where all three droplet sizing systems were operated simultaneously.
Studies on δ-Aminolevulinic Acid Synthetase Activity in Bone Marrow in Experimental Lead Poisoned Rats (1974)

Urinary increase of δ-aminolevulinic acid and coproporphyrin as well as basophilic stippled cells in the peripheral blood are the characteristic signs of lead poisoning. The biochemical lesion of porphyrin biosynthesis in lead poisoning is the partial inhibition of δ-aminolevulinic acid dehydratase, but whether or not δ-aminolevulinic acid synthetase is induced (stimulated) or not by lead is still unknown. This paper reports that δ-aminolevulinic synthetase activity in bone marrow in lead poisoned rats was 6.8 times higher than that of normal rats. Activity was found to increase within three or four days after lead administration and in parallel with the urinary increase of δ-aminolevulinic acid.The levels of urinary δ-aminolevulinic acid and coproporphyrin in lead poisoned rats decreased markedly following the administration of mitomycin c. This phenomenon were also observed in the case of hepatic porphyria caused by diethyl-1, 4-dihydro-2, 4, 6-trimethylpyridine-3, 5-dicarboxylate poisoned rats when treated with mitomycin c.These results strongly suggest that δ-aminolevulinic acid synthetase activity is induced either directly or indirectly by lead. Excessive δ-aminolevulinic acid thus formed seems to overcome the partial blocking of δ-aminolevulinic acid dehydratase resulting in the increased formation of coproporphyrin in lead poisoning.
Lifting of Steel Coils in Bore-vertical Orientation (2007)

Abstract: Lifting of coils with the bore in the vertical orientation could give rise to safety issues if the coil integrity is compromised during the slitting and packing operation. Coil telescoping (whereby the inner wraps of the coil spiral out) is known to occur during lifting, which could pose as a serious threat to the safety of personnel involved. In this type of incident, the coil straps are also broken when their breaking strength is exceeded and the whole coil would unwrap itself at an elevated position. Back tension is applied to the strip while shearing wide strip into narrower slits; this allows sufficient radial pressure to be built up within the bulk of the narrow coils. Upon unloading, the radial pressures at the innermost and outermost wraps decrease to zero but the bulk of the inter-wrap pressure within the coil remains largely unchanged. The interwrap frictional forces developed within the coil enable the coil to retain its integrity under its own weight. It is found that the radial pressures developed within the slit coil play the most crucial role in providing sufficient frictional resistance to support the weight of the coil wraps during lifting with the bore in the vertical orientation. In addition, the inter-wrap pressures near the footprint of the mechanical lifting device, near the bore, have the most significant influence in preventing coil telescoping.
Introduction to Parallel Algorithms (1998)

FOUNDATIONS OF PARALLEL COMPUTING. Elements of Parallel Computing. Data Structures for Parallel Computing. Paradigms for Parallel Algorithm. Simple Algorithms. ALGORITHMS FOR GRAPH MODELS. Tree Algorithms. Graph Algorithms. NC Algorithms for Chordal Graphs. ARRAY MANIPULATION ALGORITHMS. Searching and Merging. Sorting Algorithms. NUMERICAL ALGORITHMS. Algebraic Equations and Matrices. Differentiation and Integration. Differential Equations. Answers to Selected Exercises. Index.
Remote patient monitoring (2013)

While significant effort has been made on designing Remote Monitoring Systems (RMS), limited research has been conducted on the potential cost savings that these systems offer in terms of reduction in readmission costs, as well as the costs associated with human resources involved in the intervention process. This paper is particularly interested in exploring potential cost savings that an analytics engine can provide in presence of intelligent back-end data processing and machine learning algorithms against conventional RMS that operate based on simple thresholding approaches. Using physiological data collected from 486 heart failure patients through a clinical study in collaboration with the UCLA School of Medicine, we conduct a retrospective data analysis to estimate prediction accuracy as well as associated costs of the two remote monitoring approaches. Our results show that analytics-based RMS can reduce false negative rates by 61.4% while maintaining a false positive performance close to that of conventional RMS. Furthermore, the proposed analytics engine achieves 61.5% reduction in the overall readmission costs.
Apple Micrografting Protocol to Establish Transgenic Clones on Field Ready Rootstock (2003)

A protocol for micrografting shoot tips harvested from in vitro shoot cultures directly to transplanted rootstock plants in the greenhouse was developed. Shoot tips of the apple ( Malus domestica) cultivars Golden Delicious, Granny Smith and Fuji clone, Nagafu12, were harvested, stored in a water bath then prepared for grafting by cutting the stem immediately below the tip into a wedge shape leaving the tip approximately 3 mm (0.12 inch) long. The rootstock cultivar, Malling 9 (M.9) ( M. domestica ), was prepared by cutting into a young fast growing side branch to expose the cambium, creating a pocket into which the shoot tip was inserted. The cut section of the tip was oriented so as to contact the exposed rootstock cambium and was held in place by wrapping with a strip of pliable plastic film. Two weeks later the wrapping was loosened and the grafted branch cut back. Side branches of the rootstock were not removed until later in order to support rootstock growth. The scion shoots developed into nursery whips suitable for transplanting to a screen house or field after 2 months. The protocol proved to be a simple efficient way to rapidly grow nursery trees from tissue culture clones developed in genetic modification experiments and was used to propagate several hundred plants. Grafting success was often 100% but was reduced if quality of shoot tips was poor due to injury indicated by brown tip color. The protocol eliminates the steps of rooting, acclimatizing and growing shoots into plants to serve as a scion wood source.
The potential protective effect of tramiprosate (homotaurine) against Alzheimer's disease: a review. (2012)

Due to the progressive aging of the population and to the age-associated increase in its incidence, Alzheimer's disease (AD) will become in near future one of the major challenges that healthcare systems will have to face with in developed countries. Since the pathophysiological process of AD is thought to begin many years before the clinical diagnosis of dementia, in theory there is an opportunity for preventive therapeutic interventions. In recent years, there has been a growing interest, supported by a large number of experimental and epidemiological studies, in the beneficial effects of some natural compounds in preventing various age-related pathologic conditions, including brain aging and neurodegeneration. Homotaurine, a small aminosulfonate compound that is present in different species of marine red algae, has been shown, in both in vitro and in vivo models, to provide a relevant neuroprotective effect by its specific anti- amyloid activity and by its γ-aminobutyric acid type A receptor affinity. The therapeutic efficacy of homotaurine in AD has been investigated in a pivotal Phase III clinical study that did not reach its pre-defined primary endpoints. However, post-hoc analyses have shown positive and significant effects of homotaurine on secondary endpoints and subgroups of patients, including a reduction in hippocampal volume loss and lower decline in memory function in the overall cohort, as well as a reduction in global cognitive decline in APOE4 allele carriers, suggesting a disease-modifying effects. In this review, we will examine the pre-clinical and clinical evidence supporting the potential role of homotaurine as a promising candidate for both primary and secondary prevention of AD.
Decade-bandwidth low cross-polarization UWB array (2016)

The proposed Sliced Notch Antenna (SNA) array fixes the longstanding problem of high cross-polarization radiation in Vivaldi arrays while maintaining their excellent wideband wide-scan impedance performance with a simple reconfiguration of the Vivaldi fins. The enabling technical innovation is the introduction of discontinuities at the upper region of the flared fins that control the ratio of vertical-to-horizontal current density, without introducing sizable reflections. Measurements and simulations suggest a 10:1 (1.2-12 GHz) SNA array operation with good scanning VSWR out to 45°, and about 15 dB polarization purity improvement over a well-designed Vivaldi counterpart.
High-rate direct-sequence spread spectrum (2004)

Direct-sequence spread spectrum is popular for commercial wireless local-area networks, because license-free operation is permitted in certain frequency bands. The extensive development of equipment for such applications makes it attractive to investigate the use of the commercial technology for military communication networks. However, because of the small processing gain that is common in the signal designs for commercial direct-sequence spread spectrum, most commercial waveforms are not suitable for channels with interference, such as multiple-access channels. We investigate a class of proposed commercial high-rate spread-spectrum signal designs for which the spreading is derived primarily from nonbinary orthogonal or quasiorthogonal data modulation. The multiple-access capability is evaluated as a function of the signal-to-interference ratio, and the effects of multipath interference are investigated.
<title>Direct VCSEL launch into large-core multimode fiber: enhancement of the bandwidth x distance product</title> (1997)

Traditionally, large core (greater than 100 micron) step index multimode optical fiber has occupied a reactively small niche of applications in data communications. While the large diameter of this type of fiber makes it easy to align to optoelectronic devices, its bandwidth*distance (BW*D) product is low due to modal dispersion between the large number of modes supported by a fully filled fiber. Recently, interest has been renewed in using an underfilled launch to excite 62.5 micron core graded index multimode fiber as a way to improve its bandwidth performance. With the proper launch conditions, this same effect has been measured in large core fiber. A vertical cavity surface emitting laser (VCSEL) is used to provide a low numerical aperture launch into a large core fiber, which has a relatively large numerical aperture. The laser thus underfills the modes of the fiber, and a bandwidth enhancement for the fiber is obtained. Results of experiments performed on step and graded index large core multimode fibers using a direct VCSEL launch are presented. In addition, these relaxed alignment tolerance fibers allow the utilization of very low cost cabling and connectorization procedures for parallel optical fiber cables. Data, including skew, bandwidth, and insertion loss, are presented on these cables.© (1997) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Velocity field control for free-form contour following tasks by a two link robot (2008)

The idea of velocity field control has recently been used to tackle contour following problems. Although promising results have been reported in previous studies, the contour to be followed used in those studies were not represented in the form of non-uniform rational B-spline (NURBS), which is the fundamental geometric representation in many CAD/CAM systems. In order to extend velocity field control to contours represented in NURBS form, this paper develops a novel approach that constructs the velocity fields at pre-selected grid points. For any point not on the desired contour, its associated velocity field can be calculated in real-time using a simple interpolation formula and the velocity fields at nearby grid points. Several contour following experiments were conducted with a two-link robot to demonstrate the effectiveness of the proposed approach. Experimental results indicate that the proposed approach is feasible.
Low Sidelobe SAW Filters Using Overlap and Withdrawal Weighted Transducers (1977)

Abstract : In order to avoid frequency spurious signals in bandpass filtering applications, low out-of-band sidelobes are necessary. The purpose of the present paper is to describe in detail the techniques necessary to achieve 60-70 dB sidelobe SAW filters operating in the UHF Region. These techniques include the use of withdrawal weighted (WW) transducers either as both input and output of the filter or in combination with overlap apodized transducers plus a thorough understanding and control of second order effects. The utility of these procedures will be illustrated by a description of the design, fabrication and testing of a 335 MHz, 0.34 percent bandwidth, 15 dB insertion loss, SAW filter on ST quartz having sidelobes and all other spurious (electromagnetic feedthru and 'bulk' mode interference) at least 63 dB below the output. In addition, experimental examples of design parameter variations and second order effects will be presented and correlated with theory where appropriate.
GeneRank: Using search engine technology for the analysis of microarray experiments (2005)

Our modification of the PageRank algorithm provides an alternative method of evaluating microarray experimental results which combines prior knowledge about the underlying network. GeneRank offers an improvement compared to assessing the importance of a gene based on its experimentally observed fold-change alone and may be used as a basis for further analytical developments.