gebhart/patrepeval huggingface dataset:
Two-Dimensional Transferred Nuclear Overhauser Effect Spectroscopy Study of the Conformation of MgATP Bound at the Active and Ancillary Sites of Rabbit Muscle Pyruvate Kinase (1994)

Pyruvate kinase binds one adenosine 5'-triphosphate (ATP) molecule at its active site and another at an ancillary site on each subunit. In order to determine the conformation of ATP bound at these sites, proton transferred two-dimensional nuclear Overhauser effect spectroscopy (TRNOESY) measurements were made at 500 MHz and 10 degrees C for several mixing times in the range 40-200 ms. The NOE values for the proton pair H1'-H2' of ribose (which are 2.9 +/- 0.2 A apart, irrespective of nucleotide conformation) as a function of ligand concentration (1-10 mM ATP), with the ratio of ligand to enzyme being kept constant, indicate that at higher ligand concentrations adventitious binding of ATP at nonspecific site(s) makes a major contribution to the observed NOEs. When the ligand concentration is < 2 mM, site-specific NOEs can be measured. Furthermore, addition of phosphoenolpyruvate (PEP) to the enzyme-MgATP sample results in competitive displacement of MgATP from the active site and reduces the observed NOE to that arising exclusively at the ancillary site, thus allowing the measurement of site-specific NOEs. The interproton distances determined from such site-specific NOE buildup curves were used as constraints in CHARMm to obtain the structure of MgATP. At the active site, MgATP has a glycosidic torsion chi = 44 +/- 5 degrees and the phase angle of pseudorotation for ribose P = 42.4 degrees. At the ancillary site chi = 46 +/- 5 degrees and P = 127.6 degrees. Thus the orientation of the adenine with respect to the sugar moiety is the same at both sites.(ABSTRACT TRUNCATED AT 250 WORDS)
Expression of the extracellular matrix protein periostin in liver tumours and bile duct carcinomas (2010)

The EMT protein periostin is expressed in the stroma and epithelium of a subset of BDC and HCC. Epithelial periostin expression is a marker for malignant transformation of hepatocytes and a novel prognostic marker in BDC.
The Suppressor‐mutator element and the evolutionary riddle of transposons (1999)

This review focuses on the epigenetic control of the maize Suppressor-mutator (Spm) transposon and the evolutionary origin of epigenetic mechanisms. Methylation of the Spm promoter prevents transcription and transposition, and the methylation of the adjacent GC-rich sequence renders the inactive state heritable. Spm encodes an epigenetic activator, TnpA, one of the two Spm-encoded transposition proteins. TnpA can reactivate an inactive, methylated Spm both transiently and heritably, and it is also a transcriptional repressor of the unmethylated Spm promoter. Features common to epigenetic mechanisms in general suggest that they originated as a means of decreasing the recombinogenicity of duplicated sequences.
Nonsense-Mediated Decay of Mutant<i>waxy</i>mRNA in Rice (2001)

Two rice (Oryza sativa) waxy mutations of the Japonica background were shown to contain approximately 20% of the fully spliced mRNA relative to the wild type. Sequencing analysis of the entire waxy genes of the two mutants revealed the presence of premature translation termination codons in exon 2 and exon 7. These results indicated that the lower accumulation of fully spliced RNA in the mutants was caused by nonsense-mediated decay (NMD), which is an RNA surveillance system universally found in eukaryotes. It is interesting that levels of RNA retaining intron 1 were not changed by premature nonsense codons, suggesting that splicing may be linked with NMD in plants, as previously found in mammalian cells. Measurements of the half-lives of waxy RNAs in transfected rice protoplasts indicated that the half-life of waxy RNA with a premature nonsense codon was 3.3 times shorter than that without a premature nonsense codon. Because the wild-type waxy transcripts, which are derived from the Wx(b) gene predominantly distributed among Japonica rice, have been shown to be less efficiently spliced and their alternative splicing has been documented, we examined whether these splicing properties influenced the efficiency of NMD. However, no effects were observed. These results established that NMD occurs in rice waxy RNA containing a premature nonsense codon.
Fortune Favors the Bold (and the Italicized): Effects of Disfluency on Educational Outcomes (2010)

Research has shown that disfluencythe metacognitive experience of difficulty associated with a cognitive taskengenders deeper processing.Since deeper processing typically leads to better retention, this paper examined whether decreasing perceptual fluency of educational materials would improve retention.Study 1 found that harder to read fonts led to increased retention in a controlled laboratory setting.Study 2 extended this finding to realworld classroom environments.It appears as though perceptual disfluency can function as a desirable difficulty in education.Implications and caveats are discussed.
TECHNICAL ASPECTS OF ORTHO-PARAHYDROGEN CONVERSION (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTECHNICAL ASPECTS OF ORTHO-PARAHYDROGEN CONVERSIONGeorge E. Schmauch and Alan H. SingletonCite this: Ind. Eng. Chem. 1964, 56, 5, 20–31Publication Date (Print):May 1, 1964Publication History Published online1 May 2002Published inissue 1 May 1964https://pubs.acs.org/doi/10.1021/ie50653a003https://doi.org/10.1021/ie50653a003research-articleACS PublicationsRequest reuse permissionsArticle Views1010Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Experimental Studies of Virtual Reality-Delivered Compared to Conventional Exercise Programs for Rehabilitation (2003)

This paper presents preliminary data from two clinical trials currently underway using flat screen virtual reality (VR) technology for physical rehabilitation. In the first study, we are comparing a VR-delivered exercise program to a conventional exercise program for the rehabilitation of shoulder joint range-of-motion in patients with chronic frozen shoulder. In the second study, we are comparing two exercise programs, VR and conventional, for balance retraining in subjects post-traumatic brain injury. Effective VR-based rehabilitation that is easily adapted for individuals to use both in inpatient, outpatient and home-based care could be used as a supplement or alternative to conventional therapy. If this new treatment approach is found to be effective, it could provide a way to encourage exercise and treatment compliance, provide safe and motivating therapy and could lead to the ability to provide exercises to clients in distant locations through telehealth applications of VR treatment. VR is a new technology and the possibilities for rehabilitation are only just beginning to be assessed.
Using a cross-language information retrieval approach to improve Computer-Aided Translation performance (2010)

Translation memories play a vital role in Computer-Aided Translation (CAT). Approaches to align sentences from parallel corpora are generally used to construct translation memories. In this paper, we present, on the one hand, a hybrid approach to align sentences combining different information sources (bilingual lexicon, sentence length and sentence position, semantic similarity), and on the other hand, a Computer-Aided Translation prototype based on a cross-language information retrieval approach. This approach consists in building a database of source and target sentences augmented with grammatical information of words and considering the sentence to translate as a "query" to that database. The Computer-Aided Translation prototype has been experimented on a set of examples and the experimental results we obtained are encouraging and outperform the current CAT tools.
Mouse Monoclonal Antibodies with Restricted Specificity for Human Renal Cell Carcinoma and Ability to Modulate the Tumor Cell Growth In Vitro (1988)

Three mouse monoclonal antibodies (MAbs), KRC-1, -2 and -3(IgG1) were produced against cultured cells of human renal cell carcinoma (RCC) cell lines. All of them had restricted specificity for subset of RCC, but did not react with other tumor cell lines, tumor and normal tissues including kidney. The effect of these MAbs on the tumor cell growth in vitro was examined both in soft agar and in plate culture systems. All of them showed modulator effect on the tumor cell growth: KRC-1 showed stimulation effect and others, KRC-2 and -3, suppression one in the both systems. The specificity was observed in the modulator effects. KRC-1 detected a 135 kd glycoprotein in immunoblotting. KRC-2 detected a high molecular weight antigen (ca. 1200 kd) in gel filtration. All the antigens showed affinity for Con A lectin. Molecular properties of the antigens appeared to be different from those of previously reported RCC-associated antigens. The three MAbs seem to be useful to study mechanism of growth regulation in transformed cells.
<i>Treponema pallidum and Borrelia burgdorferi</i> lipoproteins and synthetic lipopeptides activate monocytes/macrophages. (1995)

The observation that the major membrane immunogens of the spirochetal pathogens. Treponema pallidum and Borrelia burgdorferi are lipoproteins prompted studies to investigate macrophage activation by the 47-kDa lipoprotein of T. pallidum and the acylated outer surface protein A (OspA) of B. burgdorferi. Both lipoproteins induced the synthesis of biologically active TNF-alpha and chloramphenicol acetyltransferase in a murine macrophage cell line transfected with a chloramphenicol acetyltransferase reporter gene controlled by a TNF promoter (TB2 cells). Nonacylated forms of these polypeptides did not induce cell activation. Comparison between purified OspA and B. burgdorferi cellular lipids revealed that the former was the more potent inducer of TNF-alpha. Synthetic lipohexapeptides corresponding to the N-termini of the 47-kDa lipoprotein of T. pallidum and OspA also activated TB2 cells in a dose-dependent fashion, whereas the nonlipidated hexapeptides were without effect, further underscoring the importance of protein acylation to cell activation. Among several lines of evidence supporting that macrophage stimulation by LPS and lipopeptides proceeds via different mechanisms, the most notable was that lipopeptides activated peritoneal macrophages from LPS-nonresponsive C3H/HeJ mice. The potential for spirochetal lipoproteins to function as general macrophage activators was demonstrated by the ability of the synthetic analogues to induce IL-1 beta, IL-6, and IL-12, in addition to TNF, in murine and/or human macrophages. Our findings indicate that spirochetal lipoproteins may be important immunomodulators in syphilis and Lyme disease and that the synthetic lipopeptides will be useful surrogates for studying immune mechanisms operative in the two spirochetal diseases.
Palladium-Catalyzed Coupling of Pyrazole Triflates with Arylboronic Acids (2005)

[reaction: see text] A general protocol for the palladium-mediated Suzuki coupling reaction of pyrazole triflates and aryl boronic acids has been developed. The use of additional dppf ligand was determined to increase product yields allowing for the use of a broad range of reaction substrates.
Managing periodontal disease: the clinician's role and the patient's responsibility (2013)

This manuscript highlights the roles and responsibilities of the clinician and patient in the successful management of periodontal disease. Clinical relevance: This article highlights the variety of factors that need to be addressed for periodontal diseases to be successfully managed. Learning objective: The reader should understand the broad range of issues that require consideration for patients to be successfully managed for their periodontal problems.
Fail-safe motion planning of autonomous vehicles (2016)

Formally verified methods for motion planning are required in order to guarantee safety for autonomous vehicles. In particular, we consider trajectory generation by considering the most probable trajectory of other traffic participants. However, if the surrounding vehicles perform unexpected maneuvers, a collision might be inevitable. In this paper, a fail-safe motion planner is developed, which generates optimal trajectories, yet guarantees safety at all times. Safety is achieved by maintaining an emergency maneuver which can safely bring the host vehicle to a stop while avoiding any collision. The emergency maneuver is computed by considering for a given time horizon the occupancy prediction which encloses all possible trajectories of the other traffic participants. The performance of the approach is evaluated through simulation against real traffic data.
Plasma fibrinogen--a major coronary risk factor. (1985)

The role of plasma fibrinogen as a potential indicator of susceptibility to heart attacks was studied in a sample of 297 men aged 40-69 years at entry who were initially free from overt coronary heart disease. During a mean observation period of 7.3 years (range 0.1-16.1) new heart attacks occurred in 40 men. There was a significant positive correlation between initial plasma fibrinogen levels and the subsequent incidence of heart attacks. In men with high cholesterol or high systolic blood pressure levels the incidence of heart attacks was respectively six times and 12 times greater in those with high plasma fibrinogen levels than in those with low fibrinogen levels. In multivariate models plasma fibrinogen was a highly significant and independent explanatory variable, at least as important as serum cholesterol, blood pressure or cigarette smoking. These results suggest that high plasma fibrinogen levels are an important coronary risk factor and should be included in profiles used to identify those at high risk of heart attacks.
Vaginal birth after cesarean: a 5-year experience in a family practice residency program. (1995)

We report a successful VBAC program at a community-hospital-based family practice residency program.
Online quality monitoring of welding processes by means of plasma optical spectroscopy (2000)

An optical monitoring system for the welding process has been developed; it is based on the study of the optical emission of the welding plasma plume, created during the welding of stainless steels and other iron-based materials. In the first approach a continuous wave CO2 laser of 2500-Watt maximum power, available at the INFM Research Unit labs in Bari University, has been used as welding source. A detailed spectroscopic study of the visible and UV welding plasma emission has been carried out; many transition lines corresponding to the elements composing the material to be welded have been found. By means of an appropriate selection of these lines and suitable algorithms, the electronic temperature of the plasma plume has been calculated and its evolution recorded as a function of several welding parameters. The behavior of the registered signal has resulted to be correlated to the welded joint quality. These findings have allowed to design and assemble a portable, non-intrusive and real-time welding quality optical sensor which has been successfully tested for laser welding of metals in different geometrical configurations; it has been capable of detecting a wide range of weld defects normally occurring during industrial laser metal-working. This sensor has also been tested in arc welding industrial processes (TIG) with promising results.
Climatically driven change in soil carbon across a basalt landscape is restricted to non-agricultural land use systems (2017)

Soils represent a significant component of the global terrestrial carbon cycle. Historical soil carbon depletion resulting from soil and land management offers an opportunity to store additional carbon to offset greenhouse gas emissions as part of our international response to climate change. However, our ability to reliably measure, estimate and predict soil carbon storage is hindered by a range of sources of variability, not least of which is change through time. In the present study, we assessed temporal changes in soil organic carbon (SOC) and its component fractions in response to climate alone and in the absence of land use change at any given site by examining a series of soil monitoring sites across a basalt landscape in north-west New South Wales under a range of land use types over a 3-year period (March–April 2008 and March–April 2011), where a significant rainfall event had occurred in the intervening time (2010). Across the dataset, woodland soils contained the largest carbon concentration (SOC%) and total organic carbon stock (TOCs) compared with other non-wooded land use systems, which themselves were statistically similar. However, larger carbon quantities were restricted largely to the surface (0–10 cm) soil layers. Between 2008 and 2011, significant increases in SOC% and TOCs were detected, but again these were restricted to the woodland sites. No change in particulate organic carbon (POC) was detected between the two sampling times, but both humic organic carbon (HOC) and resistant organic carbon (ROC) increased in woodland soils between the two sampling times. Increased HOC we attribute to microbial processing of soil carbon following the 2010–11 rainfall event. However, we suggest that increased ROC results from limitations in mid-infrared calibration datasets and estimations. We conclude that the quantity of soil carbon and its component fractions is, indeed, driven by climatic factors, but that these effects are moderated by aboveground land use and SOC inputs.
Retrievable vena caval filter percutaneously introduced. (1985)

A vena caval filter than can be introduced percutaneously via the femoral vein is described. We placed these filters in five patients without complications. Experimental work in filter removal one to two weeks after insertion in dogs has been performed.
TATA box binding protein and ribosomal protein 4 are suitable reference genes for normalization during quantitative polymerase chain reaction study in bovine mesenchymal stem cells (2020)

This study proposes that TBP and RPL4 were suitable as stable RGs for qPCR study in bovine MSCs.
Comparing treatment response and complications between podophyllin 0.5%/0.25% in ethanol vs podophyllin 25% in tincture benzoin for penile warts. (1998)

This study demonstrates that 0.5% podophyllin (and possibly 0.25% podophyllin) in ethanol is effective in eradicating penile warts. It can be used by patients for self-treatment at home with greater convenience and is more cost effective than the conventional podophyllin 25% in tincture benzoin paint.
Protective Effect of the Angiotensin-Converting Enzyme Inhibitor Captopril on Postischemic Myocardial Damage in Perfused Rat Heart (1997)

This study was undertaken to examine whether a sulfhydryl-containing angiotensin-converting enzyme (ACE) inhibitor, captopril, improves postischemic cardiac function and myocardial metabolism in the perfused working rat heart, and to elucidate the mechanism by which captopril protects the myocardium from postischemic damage. Isolated rat hearts were perfused by the working heart technique for 15 min. Ischemia was then induced for 30 min by lowering the afterload pressure and coronary flow to zero. After ischemia, hearts were reperfused for 30 min by returning afterload pressure to 60 mmHg. Captopril, a non-sulfhydryl-containing ACE inhibitor, enalapril, or a type 1 angiotensin II receptor antagonist, DuP 753, was added to the perfusate 5 min before ischemia, and the treatment was continued during the first 10-min period of reperfusion. In all groups there was no significant difference in pressure-rate product, coronary flow, tissue levels of ATP, total adenine nucleotides (TANs), energy charge potential (ECP), or creatine phosphate (CrP) before and during ischemia. During reperfusion following ischemia, captopril significantly improved the recovery of pressure-rate product, coronary flow, and tissue levels of ATP, TAN, ECP, and CrP, but neither enalapril nor DuP 753 had an effect. In conclusion, captopril improved postischemic cardiac function and myocardial metabolism in the perfused rate heart and its effect was independent of the blunting of angiotensin II formation.
Bio-Stoning of Denim- An Environmental-Friendly Approach (2017)

The Current Trends in Biomedical Engineering & Biosciences is an Open Access journal publishing Original research articles, Reviews, Mini reviews, Short communications, Opinions and Letter to editors with high impact. This open access Journal is enthusiastic in the development and dissemination of knowledge concerning Biomedical Engineering & Biosciences: seeks to close the gap between engineering, medicine and scientific, coalesce the design and problem-solving skills of engineering with medical and biological sciences which helps in development of sophisticated instruments which are used for the advance health care treatment, including diagnosis, monitoring, and therapy.Biosciences cover the significant developments in the broad field of biology and biological aspects of living organisms. Current Trends in Biomedical Engineering & Biosciences is peer reviewed journal that includes the topics Animal Sciences, Cell Biology and Life Sciences.
Collaborative In-Network Processing for Target Tracking (2003)

This paper presents a class of signal processing techniques for collaborative signal processing in ad hoc sensor networks, focusing on a vehicle tracking application. In particular, we study two types of commonly used sensors—acoustic-amplitude sensors for target distance estimation and direction-of-arrival sensors for bearing estimation—and investigate how networks of such sensors can collaborate to extract useful information with minimal resource usage. The information-driven sensor collaboration has several advantages: tracking is distributed, and the network is energy-efficient, activated only on a when-needed basis. We demonstrate the effectiveness of the approach to target tracking using both simulation and field data.
Key Practices of the Capability Maturity Model Version 1.1 (1993)

This document provides the key practices that correspond to each maturity level of the Capability Maturity Model and information on how to interpret the key practices. It is an elaboration of what is meant by maturity at each level of the CMM and a guide that can be used for software process improvement, software process assessments, and software capability evaluations.