gebhart/patrepeval huggingface dataset:
A V.H.F. multifrequency and multipolarization radar: preliminary results (2002)

We present a new affordable VHF multifrequency and multipolarization radar called MOSAR, a system for the analysis of target resonances (Maquette Orientee pour un Systeme d'Analyse de Resonances). This project deals with aircraft radar cross section measurements in the low VHF frequency band (20-100 MHz). At first, we present the basic principles of this project. We give some reasons for the technical choices and then we describe the radar system (including antenna, receiver and transmitter). In the second part, we present and discuss preliminary results we have obtained. Several RCS measurements with two simultaneously transmitted frequencies, in the low VHF frequency band are presented.
The causes and strategies for ventilator-associated pneumonia (2009)

Objective To explore the causes and prevention treatment strategies of ventilator-associated pneumonia (VAP) during mechanical ventilation.Methods Observations of 85 cases were made who received mechanical vetilation more than 48 hours in MICU. The diagnosis of ventilator-associated pneumonia was conducted: through observing temperature, aspirating secretions nongxing from trachea, WBC, sputum culture, and X-rays.Results 40 cases were diagnosed as VAP among 85 cases who received mechanical ventilation more than 48 hours.The incidence rate of VAP was 47%. Among them, 16 cases were simple pathogen, 24 cases had two or more pathogens. The results of pathogen culture were as follows: 16 cases had pseudomonas aeruginosa, 12 cases had staphylococcus aureus, 16 cases had klebsiella pneumonia, 12 cases had candida albicans, 10 cases had escherichia coli.Conclusion Pseudomonas aeruginosa, staphylococcus aureus, klebsiella pneumonia and candida albicans, are the major bacterium of VAP. Taking active prevention treatment strategies is the important measure, which will shorten the mechanical ventilation time and increase the survival rate.
The Role of Blood-Brain Barrier Studies in the Pharmaceutical Industry (2006)

The blood-brain barrier (BBB) remains one of the greatest challenges for the discovery and development of treatments for CNS disorders, which to this day remains one of the riskiest disease areas in terms of clinical success rates. Although the BBB is currently seen predominantly as a permeability obstacle for CNS drug delivery, it is becoming increasingly clear that the BBB has many more implications for the pharmaceutical industry impacting on CNS pharmacology and pathology, CNS pharmacokinetics and pharmacodynamics, and adverse CNS effects, to name but a few areas. The present review does not intend to summarize the activities in the field of BBB research per se, which has been accomplished by a number of excellent recent reviews, but instead to provide an overview of the role of BBB studies from a pharmaceutical industry perspective. This review will elaborate on the specific needs in terms of BBB-related issues across the different drug discovery and development phases, i.e. target identification and validation, lead generation and optimization, candidate selection and profiling, preclinical development and clinical studies. The specific approaches taken will be discussed in terms of specific requirements, questions to be asked, feasibility, interpretability, and impact. It becomes clear that few of the existing BBB models fully meet the requirements of the industrialized drug discovery process, highlighting the need for an array of new or modified tools and approaches that are more effective in helping make decisions which are more specifically tailored to the various stages of the lengthy process from target to the clinic. In looking at the numerous ongoing activities in the area of BBB research from the drug discovery and development point of view, an attempt has been made to place a stronger emphasis on the applicability of particular techniques and approaches, to identify gaps and areas for future activities. In order to materialize the considerable knowledge gained in recent years, the review is intended to foster an increased awareness of the need to better integrate basic academic research with the specific requirements of the pharmaceutical industry for the search of effective and safe new CNS medicines.
Dielectric characterization of sol-gel derived sn doped ZrTiO<sub>4</sub> thin films (1997)

Abstract High-quality thin film dielectric materials are critical for the next generation of integrated microwave devices. Much recent attention has been focused on ZrTiO4 and Sn doped ZrTiO4 films for applications in these devices. Sol-gel derived Sn doped ZrTiO4 thin films were prepared on Si and platinized Si wafers and fired to temperatures ranging from 550°C to 700°C. Multiple spincoating was performed to obtain films up to 0.5μm thick, with intermediate firings at 400°C between coatings. The ZrTiO4 films exhibited a dielectric constant of about 32 with low leakage currents of 2×10−9 A. These films were crystalline when fired to 700°C or above. The addition of Sn lowered the dielectric constant but also improved the dissipation factor. Key Words: ZrTiO4 thin filmssol-geldielectric constantdissipation factor
Decreased Acute Thrombogenicity of Human Umbilical Veins after Heparin and Alcohol Treatment (1983)

Nine glutaraldehyde-tanned human umbilical veins (GAUV) were incubated in heparin followed by storage in ethyl alcohol 50% (HAUV). These grafts were compared to five GAUV flushed with a heparinized solution without subsequent treatment in alcohol (HsAUV) and four nonheparinized GAUV (NHUV) placed in the contralateral carotid arteries of dogs for approximately 3 h. The thrombogenicity was evaluated by measuring the platelet adhesion and aggregation (51Cr), fibrinogen accumulation (125I-fibrinogen), the thrombus-free surface and the thrombus weight. The HAUV had the lowest 51Cr radioactivity. The means of thrombus-free surface and thrombus weight for the grafts were as follows: HAUV, 82% and 0.3 g (n = 9); HsAUV, 53% and 0.6 g (n = 5); NHUV, 13% and 1.2 g (n = 4). The HAUV showed a lower thrombogenicity than both the NHUV and the HsAUV grafts.
Tandem Modular Protein-Based Hydrogels Constructed Using a Novel Two-Component Approach (2011)

Leucine zipper sequences have been widely used to engineer protein-based hydrogels for biomedical applications. Previously, we have used this method to engineer tandem modular protein-based hydrogels as a step toward developing extracellular matrix-mimetic hydrogels. However, the spontaneous self-association of leucine zipper sequences in solution has made it challenging to express and purify tandem modular proteins carrying leucine zipper under native conditions. To obviate this problem, here we report a novel two-component approach to engineer tandem modular protein-based hydrogels. This methodology makes use of two complementary leucine zipper sequences (CCE and CCK), which do not self-associate but self-assemble into heterodimeric coiled-coils at neutral pH, as functional groups to drive the self-assembly of protein hydrogels. The two protein components are bifunctional and trifunctional tandem modular proteins carrying the leucine zipper functional groups. We found that the two proteins carrying CCE or CCK can be expressed and purified under native conditions with high yield. Upon mixing, the aqueous solution of the two proteins readily forms a transparent hydrogel. The resultant hydrogel can undergo reversible sol-gel transitions as a function of temperature, and shows much improved erosion properties. This method provides a new approach to tune the topology and physical properties of the protein hydrogels via genetic engineering, and opens the possibility to systematically explore the use of large native extracellular proteins to engineer extracellular matrix-mimetic hydrogels.
Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: The ENTRANCE study (2012)

This trial provides first evidence of clinical efficacy of vidofludimus in IBD. Although the safety and tolerability profile seems favorable, long-term controlled studies are needed to further investigate its potential as novel IBD therapy.
Dynein drives nuclear rotation during forward progression of motile fibroblasts (2008)

During directed cell migration, the movement of the nucleus is coupled to the forward progression of the cell. The microtubule motor cytoplasmic dynein is required for both cell polarization and cell motility. Here, we investigate the mechanism by which dynein contributes to directed migration. Knockdown of dynein slows protrusion of the leading edge and causes defects in nuclear movements. The velocity of nuclear migration was decreased in dynein knockdown cells, and nuclei were mislocalized to the rear of motile cells. In control cells, we observed that wounding the monolayer stimulated a dramatic induction of nuclear rotations at the wound edge, reaching velocities up to 8.5 degrees/minute. These nuclear rotations were significantly inhibited in dynein knockdown cells. Surprisingly, centrosomes do not rotate in concert with the nucleus; instead, the centrosome remains stably positioned between the nucleus and the leading edge. Together, these results suggest that dynein contributes to migration in two ways: (1) maintaining centrosome centrality by tethering microtubule plus ends at the cortex; and (2) maintaining nuclear centrality by asserting force directly on the nucleus.
Quantitative Tissue Factor Gene Expression Analysis in Whole Blood: Development and Evaluation of a Real-Time PCR Platform (2004)

Up-regulation of tissue factor (TF) expression in circulating blood cells, especially monocytes, plays a key role in the pathogenesis of various thromboembolic diseases (1)(2)(3)(4). Measurement of TF expression in monocytes therefore might be helpful in the diagnosis of a hypercoagulable state (5)(6)(7). Monocytic TF expression can be measured on both the protein and RNA levels. Testing on the RNA level seems to be more appropriate than antigen testing to detect a procoagulant state because monocytes that already express functionally active TF on their membrane surfaces are rapidly cleared from the circulation (8).

The aim of the present study was to develop a protocol for quantitative determination of TF mRNA transcripts in monocytes and other circulating blood cells. The method should be rapid, robust, and applicable in whole blood without the need for cell isolation. We developed a one-step quantitative reverse transcription (qRT)-PCR assay based on the real-time TaqMan® technology and evaluated the preanalytical conditions required for the use of TF mRNA measurements on a routine clinical basis as well as several normalization strategies, including normalization based on CD14 and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) reference gene expression. Finally, we measured baseline TF expression in healthy individuals and in thrombophilic patients.

RNA calibrators for quantification were prepared by in vitro transcription of DNA hybrids that combined the T7 promoter sequence with the following sequences of TF, CD14, or GAPDH cDNA: for TF, bp 265–848 (GenBank accession no. M16553); for CD14, bp 18–564 (GenBank accession no. M86511); and for GAPDH, bp 8–525 (GenBank accession no. M33197). Generated RNAs were treated with DNase I (Roche) to remove the added DNA templates and purified by use of the RNeasy Mini Kit (Qiagen). RNA was quantified by photometric measurement ( A 260 reading of 1 = 44 …
Randomized double-blind controlled trial of roxithromycin for prevention of abdominal aortic aneurysm expansion (2001)

In comparison to placebo, roxithromycin 300 mg daily for 4 weeks reduced the expansion rate of AAAs.
Simple One-Pot Synthesis of Fully Biobased Unsaturated Polyester Resins Based on Itaconic Acid (2017)

For the preparation of fully biobased unsaturated polyester resins (UPRs), the replacement of styrene with alternate nonpetroleum-based monomers turned out to be one of the most challenging tasks. Its complexity lies in the fact that reactive diluents (RD) have to have low viscosity and volatility, good compatibility with prepolymer, and capability to homopolymerize and copolymerize with its unsaturations. In this context, we directed our efforts to develop fully biobased UPRs using the dialkyl itaconates as an alternative to styrene. Therefore, a series of 100% biobased UPRs were prepared from itaconic acid and 1,2-propandiol and diluted by dialkyl itaconates. The resins were characterized by Fourier transform infrared spectroscopy, NMR, volatility, and viscosity measurements, while the cured samples were characterized by dynamic mechanical properties, thermomechanical analysis, thermogravimetric analysis data, and tensile tests. The influence of RD structure on the properties of cured samples was discussed in detail. It was shown that the prepared resins had evaporation rates of dialkyl itaconates of several orders of magnitude less compared to styrene. The cured resins with dimethyl itaconate showed comparable or even better thermal and mechanical properties compared to the one with styrene. This investigation showed that itaconic acid and dialkyl itaconates are promising bioresources for the preparation of fully biobased UPRs for mass consumption.
Anomalous Isosteric Enthalpy of Adsorption of Methane on Zeolite-Templated Carbon (2012)

A thermodynamic study of the enthalpy of adsorption of methane on high surface area carbonaceous materials was carried out from 238 to 526 K. The absolute quantity of adsorbed methane as a function of equilibrium pressure was determined by fitting isotherms to a generalized Langmuir-type equation. Adsorption of methane on zeolite-templated carbon, an extremely high surface area material with a periodic arrangement of narrow micropores, shows an increase in isosteric enthalpy with methane occupancy; i.e., binding energies are greater as adsorption quantity increases. The heat of adsorption rises from 14 to 15 kJ/mol at near-ambient temperature and then falls to lower values at very high loading (above a relative site occupancy of 0.7), indicating that methane/methane interactions within the adsorption layer become significant. The effect seems to be enhanced by a narrow pore-size distribution centered at 1.2 nm, approximately the width of two monolayers of methane, and reversible methane delivery increases by up to 20% over MSC-30 at temperatures and pressures near ambient.
Experimental and Theoretical Studies on Oxidation of Cu-Au Alloy Surfaces: Effect of Bulk Au Concentration (2016)

We report results of our experimental and theoretical studies on the oxidation of Cu-Au alloy surfaces, viz., Cu3Au(111), CuAu(111), and Au3Cu(111), using hyperthermal O2 molecular beam (HOMB). We observed strong Au segregation to the top layer of the corresponding clean (111) surfaces. This forms a protective layer that hinders further oxidation into the bulk. The higher the concentration of Au in the protective layer formed, the higher the protective efficacy. As a result, of the three Cu-Au surfaces studied, Au3Cu(111) is the most stable against dissociative adsorption of O2, even with HOMB. We also found that this protective property breaks down for oxidations occurring at temperatures above 300 K.
Iron supplementation in goitrous, iron-deficient children improves their response to oral iodized oil (2000)

Iron supplementation may improve the efficacy of oral iodized oil in goitrous children with iron-deficiency anemia.
An asymmetric distributed shared memory model for heterogeneous parallel systems (2010)

Heterogeneous computing combines general purpose CPUs with accelerators to efficiently execute both sequential control-intensive and data-parallel phases of applications. Existing programming models for heterogeneous computing rely on programmers to explicitly manage data transfers between the CPU system memory and accelerator memory. This paper presents a new programming model for heterogeneous computing, called Asymmetric Distributed Shared Memory (ADSM), that maintains a shared logical memory space for CPUs to access objects in the accelerator physical memory but not vice versa. The asymmetry allows light-weight implementations that avoid common pitfalls of symmetrical distributed shared memory systems. ADSM allows programmers to assign data objects to performance critical methods. When a method is selected for accelerator execution, its associated data objects are allocated within the shared logical memory space, which is hosted in the accelerator physical memory and transparently accessible by the methods executed on CPUs. We argue that ADSM reduces programming efforts for heterogeneous computing systems and enhances application portability. We present a software implementation of ADSM, called GMAC, on top of CUDA in a GNU/Linux environment. We show that applications written in ADSM and running on top of GMAC achieve performance comparable to their counterparts using programmer-managed data transfers. This paper presents the GMAC system and evaluates different design choices. We further suggest additional architectural support that will likely allow GMAC to achieve higher application performance than the current CUDA model.
Formation of Spherical and Non‐Spherical Eutectic Gallium‐Indium Liquid‐Metal Microdroplets in Microfluidic Channels at Room Temperature (2012)

Abstract Here, the formation of eutectic Gallium‐Indium (EGaIn) liquid‐metal microdroplets, both spherical and non‐spherical, in microfluidic devices at room temperature is reported. Monodisperse microdroplets were created in an aqueous polyethylene glycol (PEG) solution, in oxygenated and in deoxygenated silicone oil. The volume of the droplets depends on the channel dimensions and flow rates applied, varying between 0.5 and 4 nL. Non‐spherical droplets were formed in oxygenated silicone oil due to the instantaneous formation of an oxide layer. These metal “micro‐rice” droplets retained their shape and did not spontaneously reflow to form shapes of the lowest interfacial energy on egress from the channel, unlike in aqueous PEG solution and in deoxygenated silicone oil. Liquid‐metal droplets with such tunable morphology can potentially be used in MEMS devices for optical and electrical switches, valves and micropumps.
Object-oriented analysis and design of transient stability simulation for distributed power generation system (2009)

The designs of model abstraction and application abstraction of transient stability simulation for distributed power generation system are presented. The main classes are presented, which are called model classes, function classes and system integration classes. An AC/DC double layer bus-tree structure belongs to model classes for grouping elements of distributed generation system is presented, The DC bus tree structure includes subclasses of distributed sources and storages. The design scheme descries the double layer structure. In order to study the whole dynamic process of whole system, the digital simulation method capable of dealing with the stiff problem is integrated in function classes. With the efficiency and simpleness of calling mechanism for the functional functions of elements during computation, system integration classes are capable of considering the influence of typical microgrid operation modes which are grid-connected mode, island mode and grid-reconnected mode, etc, and capable of control the switchover from one mode to another mode.
Opioid-free analgesia by continuous psoas compartment block after total hip arthroplasty. A randomized study (2007)

Opioid-free continuous psoas compartment block seems to be an appropriate and reliable technique in providing effective postoperative analgesia at rest and during physiotherapy after total hip arthroplasty when compared to intravenous morphine/ketorolac infusion.
Abstract 17 (2014)

AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK
Corticosteroids in sepsis and septic shock: has the jury reached a verdict? (1989)

Mortality from septic shock remains high, despite early diagnosis, comprehensive care and monitoring, and intensive therapy. The use of high-dose corticosteroids as adjunctive therapy in septic states has been extensively debated in the literature, but no clear consensus has been reached. Main sites of action where corticosteroids can theoretically interfere with the pathophysiologic processes activated by sepsis have been identified. Early clinical studies and extensive animal research generated much enthusiasm for the use of steroids in sepsis and septic shock. Recently, however, well-designed clinical studies have consistently failed to show a beneficial effect of corticosteroid use in septic states. After re-examining the theoretical basis for the use of steroids, possible side effects, experimental results and clinical trials, it is concluded that, based upon current knowledge, high-dose corticosteroids should not be used as adjunctive therapy in human sepsis and septic shock.
Addressing IT Security for Critical Control Systems (2007)

Control systems for critical infrastructures like national power grids make increasingly use of open technologies and protocols, and the Internet. In this environment, the risk of electronic attacks on these control systems has to be evaluated and mitigated. This paper addresses the key challenges commonly mentioned in the context of control system security (also referred to as "SCADA security") and discusses feasible solutions for most of them. The paper argues that the main obstacle to control system security is not technical, but financial. A couple of exemplary research projects from one automation vendor that aim to reduce the plant owners' cost of security are presented to demonstrate what kind of research will bring control system security forward
Hardware-in-the-loop simulation for automated benchmarking of cloud infrastructures (2012)

To address the challenge of automated performance benchmarking in virtualized cloud infrastructures, an extensible and adaptable framework called CloudBench has been developed to conduct scalable, controllable, and repeatable experiments in such environments. This paper presents the hardware-in-the-loop simulation technique used in CloudBench, which integrates an efficient discrete-event simulation with the cloud infrastructure under test in a closed feedback control loop. The technique supports the decomposition of complex resource usage patterns and provides a mechanism for statistically multiplexing application requests of varied characteristics to generate realistic and emergent behavior. It also exploits parallelism at multiple levels to improve simulation efficiency, while maintaining temporal and causal relationships with proper synchronization. Our experiments demonstrate that the proposed technique can synthesize complex resource usage behavior for effective cloud performance benchmarking.