gebhart/patrepeval huggingface dataset:
Learning-Based Resource Allocation Scheme for TDD-Based 5G CRAN System (2016)

Provision of high data rates with always-on connectivity to high mobility users is one of the motivations for design of fifth generation (5G) systems. High system capacity can be achieved by coordination between large number of antennas, which is done using the cloud radio access network (CRAN) design in 5G systems. In terms of baseband processing, allocation of appropriate resources to the users is necessary to achieve high system capacity, for which the state of the art uses the users' channel state information (CSI); however, they do not take into account the associated overhead, which poses a major bottleneck for the effective system performance. In contrast to this approach, this paper proposes the use of machine learning for allocating resources to high mobility users using only their position estimates. Specifically, the `random forest' algorithm, a supervised machine learning technique, is used to design a learning-based resource allocation scheme by exploiting the relationships between the system parameters and the users' position estimates. In this way, the overhead for CSI acquisition is avoided by using the position estimates instead, with better spectrum utilization. While the initial numerical investigations, with minimum number of users in the system, show that the proposed learning-based scheme achieves 86% of the efficiency achieved by the perfect CSI-based scheme, if the effect of overhead is factored in, the proposed scheme performs better than the CSI-based approach. In a realistic scenario, with multiple users in the system, the significant increase in overhead for the CSI-based scheme leads to a performance gain of 100%, or more, by using the proposed scheme, and thus proving the proposed scheme to be more efficient in terms of system performance.
Carbon–carbon bond cleavage by cytochrome P450<sub>BioI</sub>(CYP107H1) (2003)

Cytochrome p450(BioI)(CYP107H1) is believed to supply pimelic acid equivalents for biotin biosynthesis in Bacillus subtilis: we report here that the mechanistic pathway adopted by this multifunctional p450 for the in-chain cleavage of fatty acids is via consecutive formation of alcohol and threo-diol intermediates, with the likely absolute configuration of the intermediates also reported.
Identification of <i>Turnip mosaic virus</i> Isolates Causing Yellow Stripe and Spot on Calla Lily (2003)

Two virus cultures, RC4 and YC5, were isolated in Taiwan from calla lily (Zantedeschia spp.) cv. Black magic displaying yellow spot and stripe on leaves. Both isolates were mechanically transmitted to various hybrids of Zantedeschia and induced systemic symptoms similar to those observed on diseased Black magic. In addition to Zantedeschia spp., the two virus isolates also infected several cruciferous species and induced mosaic symptoms. Electron microscopy revealed the presence of flexuous virus particles about 750 nm in length. The two isolates were propagated in and purified from mustard plants and were used as immunogens for production of antisera in rabbits. In enzyme-linked immunosorbent assay and sodium dodecyl sulfate-immunodiffusion tests, both antisera reacted strongly with their homologous antigens and with antigens of two Turnip mosaic virus (TuMV) isolates from radish (TuMV-R) and lisianthus (TuMV-L), but not with 21 other different potyviruses tested. In reciprocal tests, antisera against TuMV-R and TuMV-L also reacted strongly with RC4 and YC5 antigens, indicating that these two calla lily isolates are serologically indistinguishable from other known TuMV strains. Cloning and sequence analyses confirmed that both isolates shared 95 to 99% of deduced amino acid sequence identities in the coat protein genes with those of various known TuMV strains. This investigation represents the first record of the natural infection of TuMV in calla lily.
Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease (2016)

The Venezuelan equine encephalitis virus (VEEV) nonstructural protein 2 (nsP2) cysteine protease (EC 3.4.22.-) is essential for viral replication and is involved in the cytopathic effects (CPE) of the virus. The VEEV nsP2 protease is a member of MEROPS Clan CN and characteristically contains a papain-like protease linked to an S-adenosyl-l-methionine-dependent RNA methyltransferase (SAM MTase) domain. The protease contains an alternative active site motif, (475)NVCWAK(480), which differs from papain's (CGS(25)CWAFS), and the enzyme lacks a transition state-stabilizing residue homologous to Gln-19 in papain. To understand the roles of conserved residues in catalysis, we determined the structure of the free enzyme and the first structure of an inhibitor-bound alphaviral protease. The peptide-like E64d inhibitor was found to bind beneath a β-hairpin at the interface of the SAM MTase and protease domains. His-546 adopted a conformation that differed from that found in the free enzyme; one or both of the conformers may assist in leaving group departure of either the amine or Cys thiolate during the catalytic cycle. Interestingly, E64c (200 μM), the carboxylic acid form of the E64d ester, did not inhibit the nsP2 protease. To identify key residues involved in substrate binding, a number of mutants were analyzed. Mutation of the motif residue, N475A, led to a 24-fold reduction in kcat/Km, and the conformation of this residue did not change after inhibition. N475 forms a hydrogen bond with R662 in the SAM MTase domain, and the R662A and R662K mutations both led to 16-fold decreases in kcat/Km. N475 forms the base of the P1 binding site and likely orients the substrate for nucleophilic attack or plays a role in product release. An Asn homologous to N475 is similarly found in coronaviral papain-like proteases (PLpro) of the Severe Acute Respiratory Syndrome (SARS) virus and Middle East Respiratory Syndrome (MERS) virus. Mutation of another motif residue, K480A, led to a 9-fold decrease in kcat and kcat/Km. K480 likely enhances the nucleophilicity of the Cys. Consistent with our substrate-bound models, the SAM MTase domain K706A mutation increased Km 4.5-fold to 500 μM. Within the β-hairpin, the N545A mutation slightly but not significantly increased kcat and Km. The structures and identified active site residues may facilitate the discovery of protease inhibitors with antiviral activity.
Studies of convertible turboshaft/turbofan engines for high-speed rotorcraft (1985)

Rotary wing aircraft require auxiliary thrust to fly at speeds higher than current helicopters. One approach is to use the turboshaft engine to drive both the vehicle rotor and a variable geometry fan which allows independent variation of shp and thrust. Various convertible engine configurations including variable pitch fans, variable inlet guide vane fans, and clutched fans are described and their suitability for two types of aircraft is examined. One is a 225 knot U.S. Army combat rotorcraft in which the rotor operates in high-speed flight. The variable inlet guide vane fan with or without a clutch is shown to be a viable approach. The second aircraft is a 400 knot X-wing commercial transport in which the rotor is stopped in flight. The variable inlet guide vane fan and prop/shaft systems are shown to be competitive.
United States thrombotic thrombocytopenic purpura apheresis study group (US TTP ASG): Multicenter survey and retrospective analysis of current efficacy of therapeutic plasma exchange (1998)

Thrombotic thrombocytopenic purpura (TTP) remains enigmatic from the perspective of its etiology, pathophysiology, and treatment. Once recognized, the accepted standard of care for TTP is daily therapeutic plasma exchange (TPE). However, the diversity in TPE treatment protocols has made comparisons of clinical research between institutions difficult. This study strived to assess the current practice of TPE in order to provide direction for prospective controlled clinical trials. Twenty large apheresis centers within the United States comprising the US TTP ASG responded to a survey to establish the current status of TPE in TTP. A retrospective analysis from data provided by 14 of 20 centers included 115 initial presentations of primary TTP with an overall mortality rate of 10% and relapse rate of 37%. The majority of deaths (58%) occurred within 48 hours of presentation. Variation in therapeutic targets (platelet count [plt] and serum LDH) and the number of plasma volumes exchanged per procedure did not affect the relapse rate. Initial plt and LDH were not predictive of mortality. Response, relapse, and mortality rates with the combination of 5% albumin for the initial 50% of TPE followed by plasma for the final 50% of TPE as replacement were comparable or possibly better than plasma-only replacement strategies. Forty percent of centers routinely used a TPE taper; however, there was no statistical difference in relapse rates comparing the taper and non-taper sub-groups. By controlling for adjunctive modalities such as steroids and anti-platelet agents, it is hoped that future prospective clinical trials may optimize the role of TPE in TTP, minimize patient exposure to blood products and procedures, shorten the clinical course of TTP, and reduce mortality.
43.5L: <i>Late News Paper:</i> Prototype of a Wide Gamut Monitor Adopting an LED‐Backlighting LCD Panel (2003)

Abstract This paper presents development of a wide color gamut monitor that has 104.4 [%] color gamut comparing to NTSC color gamut. In this paper we would like to report about a prototype of wide color gamut monitor. And more we have compared color gamut of our prototype vs. some major set of standard color patches. We would like to also touch upon this comparison. Specifications of our newly developed monitors are as follows: (1) Color gamut; more than 100 [%] for NTSC, (2) Screen size; 22 [inches] (480mm * 288mm), (3) Resolution; WXGA (H; 1280 * V; 768 [pixels]), (4) Maximum brightness; more than 600 [cd/m 2 ] and (5) liquid crystal mode; IPS (In‐Plane‐Switching). (6) Supporting the bi‐directional communication function called DDC/CI (Display Data Channel Command Interface). We believe that our monitor is useful for soft proofing of DTP as replacement of conventional CRT displays. This research is organized in part by NEDO (New Energy and Industrial Technology Development Organization, Japan).
A Novel Single-Strand RNAi Therapeutic Agent Targeting the (Pro)renin Receptor Suppresses Ocular Inflammation (2017)

The receptor-associated prorenin system (RAPS) refers to the pathogenic mechanism whereby prorenin binding to the (pro)renin receptor [(P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent intracellular signaling. Here we revealed significant upregulation of prorenin and soluble (P)RR levels in the vitreous fluid of patients with uveitis compared to non-inflammatory controls, together with a positive correlation between these RAPS components and monocyte chemotactic protein-1 among several upregulated cytokines. Moreover, we developed a novel single-strand RNAi agent, proline-modified short hairpin RNA directed against human and mouse (P)RR [(P)RR-PshRNA], and we determined its safety and efficacy in vitro and in vivo. Application of (P)RR-PshRNA in mice caused significant amelioration of acute (uveitic) and chronic (diabetic) models of ocular inflammation with no apparent adverse effects. Our findings demonstrate the significant implication of RAPS in the pathogenesis of human uveitis and the potential usefulness of (P)RR-PshRNA as a therapeutic agent to reduce ocular inflammation.
Diagnosis of route leaks among autonomous systems in the Internet (2014)

Border Gateway Protocol (BGP) is the defacto inter-domain routing protocol in the Internet. It was designed without an inherent security mechanism and hence is prone to a number of vulnerabilities which can cause large scale disruption in the Internet. Route leak is one such inter-domain routing security problem which has the potential to cause wide-scale Internet service failure. Route leaks occur when Autonomous systems violate export policies while exporting routes. As BGP security has been an active research area for over a decade now, several security strategies were proposed, some of which either advocated complete replacement of the BGP or addition of new features in BGP, but they failed to achieve global acceptance. Even the most recent effort in this regard, lead by the Secure Inter-Domain Routing (SIDR) working group (WG) of IETF fails to counter all the BGP anomalies, especially route leaks. In this paper we look at the efforts in countering the policy related BGP problems and provide an analytical insights into why they are ineffective. We contend a new direction for future research in managing the broader security issues in the inter-domain routing. In that light, we propose a naive approach for countering the route leak problem by analyzing the information available at hand, such as the RIB of the router. The main purpose of this paper was to position and highlight the autonomous smart analytical approach for tackling policy related BGP security issues.
Tyrosine 264 in the recA protein from Escherichia coli is the site of modification by the photoaffinity label 8-azidoadenosine 5'-triphosphate. (1985)

The photoaffinity label 8-azidoadenosine 5'-triphosphate (N3-ATP) was used to covalently modify the recA protein from Escherichia coli within its ATP-binding site. We have previously demonstrated that N3-ATP modification of recA protein is specific for the ATP-binding site and have isolated a unique tryptic peptide (T31), spanning residues 257-280, that contains the exclusive site of attachment of this ATP analog (Knight, K. L., and McEntee, K. (1985) J. Biol. Chem. 260, 867-872). We performed a secondary proteolytic digestion of the [alpha-32P]N3-ATP-labeled T31 peptide using Staphylococcus aureus V8 protease and purified the resulting peptide fragments by high-pressure liquid chromatography (HPLC). Based on a comparison of the amino acid compositions of all purified fragments and sequence analysis of one labeled fragment we determined that Tyr-264 is the exclusive site of N3-ATP attachment in recA protein. Photoaffinity labeling of recA protein was also performed in the presence of single-stranded DNA. Following trypsin treatment and separation of peptides by HPLC we showed that tryptic peptide T31 contained the exclusive site of N3-ATP attachment. A secondary proteolytic digestion was performed on both [alpha-32P]N3ATP-modified T31 and unmodified T31 using alpha-chymotrypsin. Comparison of the HPLC profiles and amino acid compositions of the resulting fragments was consistent with Tyr-264 as the exclusive site of N3-ATP attachment to recA protein.
MAO-inhibitors in Parkinson's Disease (2011)

Monoamine oxidase inhibitors (MAO-I) belong to the earliest drugs tried in Parkinson's disease (PD). They have been used with or without levodopa (L-DOPA). Non-selective MAO-I due to their side-effect/adverse reaction profile, like tranylcypromine have limited use in the treatment of depression in PD, while selective, reversible MAO-A inhibitors are recommended due to their easier clinical handling. For the treatment of akinesia and motor fluctuations selective irreversible MAO-B inhibitors selegiline and rasagiline are recommended. They are safe and well tolerated at the recommended daily doses. Their main differences are related to (1) metabolism, (2) interaction with CYP-enzymes and (3) quantitative properties at the molecular biological/genetic level. Rasagiline is more potent in clinical practise and has a hypothesis driven more favourable side effect/adverse reaction profile due to its metabolism to aminoindan. Both selegiline and rasagiline have a neuroprotective and neurorestaurative potential. A head-to head clinical trial would be of utmost interest from both the clinical outcome and a hypothesis-driven point of view. Selegiline is available as tablet and melting tablet for PD and as transdermal selegiline for depression, while rasagiline is marketed as tablet for PD. In general, the clinical use of MAO-I nowadays is underestimated. There should be more efforts to evaluate their clinical potency as antidepressants and antidementive drugs in addition to the final proof of their disease-modifying potential. In line with this are recent innovative developments of MAO-I plus inhibition of acetylcholine esterase for Alzheimer's disease as well as combined MAO-I and iron chelation for PD.
Properties of hydrophobically associating polyacrylamides: influence of the method of synthesis (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProperties of hydrophobically associating polyacrylamides: influence of the method of synthesisAlain Hill, Francoise Candau, and Joseph SelbCite this: Macromolecules 1993, 26, 17, 4521–4532Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ma00069a017https://doi.org/10.1021/ma00069a017research-articleACS PublicationsRequest reuse permissionsArticle Views1677Altmetric-Citations349LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High Temperature Corrosion of Silicon Carbide and Silicon Nitride in Water Vapor (2002)

Silicon carbide (SiC) and silicon nitride (Si3N4) are proposed for applications in high temperature combustion environments containing water vapor. Both SiC and Si3N4 react with water vapor to form a silica (SiO2) scale. It is therefore important to understand the durability of SiC, Si3N4 and SiO2 in water vapor. Thermogravimetric analyses, furnace exposures and burner rig results were obtained for these materials in water vapor at temperatures between 1100 and 1450 C and water vapor partial pressures ranging from 0.1 to 3.1 atm. First, the oxidation of SiC and Si3N4 in water vapor is considered. The parabolic kinetic rate law, rate dependence on water vapor partial pressure, and oxidation mechanism are discussed. Second, the volatilization of silica to form Si(OH)4(g) is examined. Mass spectrometric results, the linear kinetic rate law and a volatilization model based on diffusion through a gas boundary layer are discussed. Finally, the combined oxidation and volatilization reactions, which occur when SiC or Si3N4 are exposed in a water vapor-containing environment, are presented. Both experimental evidence and a model for the paralinear kinetic rate law are shown for these simultaneous oxidation and volatilization reactions.
Extended analysis of curvature sensing (2002)

Curvature sensors are used in adaptive optics to measure the wave-front aberrations. In practice, their performance is limited by their nonlinear behavior, which we characterize by solving simultaneously the irradiance transport equation and the accompanying wave-front transport equation. We show how the presence of nonlinear geometric terms limits the accuracy of the sensor and how diffraction effects limit the spatial resolution. The effect of photon noise on the sensor is also quantified.
Identifying directed links in large scale functional networks: application to brain fMRI (2007)

Our method expands previous approaches to render large scale functional networks, and creates the basis for an extensive and -due to the presence of mixtures of directed and undirected links- richer motif analysis of functional relationships.
New Dynamic RAM Cell Combined with Hi–C Structure (1983)

A new dynamic RAM cell combined with the Hi–C structure is proposed and its effectiveness is confirmed. The feature of the new cell is to isolate each cell capacitor by the p + -region of the Hi–C structure, instead of the thick SiO 2 layer. As the result, the new cell reduces the loss in the storage capacitance by the lateral oxidation, in spite of the conventional LOCOS process. The storage capacitance of the new cell is 13% larger than that of the conventional one. The threshold voltage of the parasitic transistor for isolating adjacent cells was 2.1 V. The breakdown voltage of the new cell was 12 V, which was determined by the p-n junction of the Hi–C structure. The leakage current of the new cell was the same as that of the conventional one.
Radiology an Illustrated History (1995)

Eisenberg presents a well-illustrated, one-of-a-kind look at radiology's 100-year history. The book ranges from Roentgen's discovery of X-rays (1895) and the Curie's discovery of radioactivity (1896) to the development and growth of today's various clinical subspecialities, emphasizing human ingenuity and rapidly advancing technology.
Three New Triterpenoids from Antrodia cinnamomea (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThree New Triterpenoids from Antrodia cinnamomeaI-Hwa Cherng, Hung-Cheh Chiang, Ming-Chu Cheng, and Yu WangCite this: J. Nat. Prod. 1995, 58, 3, 365–371Publication Date (Print):March 1, 1995Publication History Published online1 July 2004Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/np50117a004https://doi.org/10.1021/np50117a004research-articleACS PublicationsRequest reuse permissionsArticle Views739Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts