gebhart/patrepeval huggingface dataset:
Crosstalk Between Epidermal Growth Factor Receptor- and Insulin-Like Growth Factor-1 Receptor Signaling: Implications for Cancer Therapy (2009)

Both the epidermal growth factor receptor (EGFR) and the insulin-like growth factor-1 receptor (IGF-1R) can contribute to tumor development and -progression through their effects on cell proliferation, inhibition of apoptosis, angiogenesis, anchorage-independent growth and tumor-associated inflammation. EGFR-targeting monoclonal antibodies and small molecule tyrosine kinase inhibitors are currently in clinical use for the treatment of several types of cancer. However, primary and acquired resistance to these agents often occurs and thereby limits the clinical efficacy of mono-specific targeted therapy. Results from both in vitro and in vivo studies indicate that cross-talk between EGFR and IGF-1R can lead to acquired resistance against EGFR-targeted drugs. This review describes the interface between the EGFR and IGF-1R signaling networks and the implications of the extensive cross-talk between these two receptor systems for cancer therapy. EGFR and IGF-1R interact on multiple levels, either through a direct association between the two receptors, by mediating the availability of each others ligands, or indirectly, via common interaction partners such as G protein coupled receptors (GPCR) or downstream signaling molecules. This multi-layered cross-talk and its involvement in the induction of resistance to targeted therapies provide a clear rationale for dual targeting of EGFR and IGF-1R. We discuss several (potential) strategies to simultaneously inhibit EGFR and IGF-1R signaling as promising novel therapeutic approaches.
Effects of Al 3+ on root growth, cell division, and nucleoli in root tip cells of Zea mays L. (2001)

The effects of different concentrations (105101 M) of aluminum chloride on root growth, cell division, and nucleoli in root tip cells of Zea mays L. were investigated. The results showed that Al inhibited root growth of Zea mays only at 102101 M.Al3+ has a marked effect on c-mitosis. Al, at higher concentration, has toxic effects on root tip cells, causing aberration of chromosomal morphology and structure: c-mitosis, anaphase bridges, and chromosome stickiness. Al induces the appearance of some silver-stained particulate material scattered in the nuclei, and extrusion of the nucleolar material from the nucleus into the cytoplasm. Once the nucleolus was affected, and silver-stained nucleolar material was extruded from the nucleus into the cytoplasm, root growth was almost or completely stopped. The possible mechanism of the Al poisoning of root tip cells of Zea mays is also briefly discussed.
Reflux symptom relief with omeprazole in patients without unequivocal oesophagitis (1996)

Omeprazole 20 mg once daily is effective in providing relief of the symptoms typical of gastro-oesophageal reflux disease in patients with essentially normal oesophageal mucosa.
Robust support recovery using sparse compressive sensing matrices (2011)

This paper considers the task of recovering the support of a sparse, high-dimensional vector from a small number of measurements. The procedure proposed here, which we call the Sign-Sketch procedure, is shown to be a robust recovery method in settings where the measurements are corrupted by various forms of uncertainty, including additive Gaussian noise and (possibly unbounded) outliers, and even subsequent quantization of the measurements to a single bit. The Sign-Sketch procedure employs sparse random measurement matrices, and utilizes a computationally efficient support recovery procedure that is a variation of a technique from the sketching literature. We show here that O(max {k log(n - k), k log k}) non-adaptive linear measurements suffice to recover the support of any unknown n-dimensional vector having no more than k nonzero entries, and that our proposed procedure requires at most O(n log n) total operations for both acquisition and inference.
A comparison of rodent caging systems based on microenvironmental parameters. (1991)

Four different mouse caging systems were evaluated for microenvironmental temperature, carbon dioxide, relative humidity (RH) and ammonia levels during a 7-day testing period. All caging systems evaluated had polycarbonate bases and consisted of either a molded polyester (MP) filter lid, one of two different polycarbonate filter lids, or no filter lid which served as a control. At 50% macroenvironmental RH (study I), all systems maintained an intracage temperature of 75.5 degrees F +/- 0.5 degrees. Both polycarbonate systems averaged greater than 2200 ppm of carbon dioxide more than the MP system and the controls. When compared with RH in the control cages, RH levels averaged over 20% and 5 to 8% RH greater in the polycarbonate filter lid systems and the MP system, respectively. There were no appreciable ammonia levels in either the MP or control systems. In the polycarbonate filter lid systems, ammonia levels were detectable on day 4 and were greater than 200 ppm by day 6. At 20% macroenvironmental RH (study II), there was a proportional 15 to 30% RH decrease from study I levels. Ammonia levels were undetectable in any system until day 7 and averaged only 17 ppm in one of the polycarbonate systems. Minimal differences were observed in studies III, IV and V when pine shavings were used instead of hardwood chips, a CD-1 stock instead of a DBA/2J strain, and different grades of filter inserts in the polycarbonate systems, respectively.
A Treatise on Qualitative Analysis. Adapted for Use in the Laboratories of Colleges and Technical Institutes. (1920)

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An Algorithm for Radio Resources Management in Integrated Cellular/WLAN Networks (2007)

Radio resources management in integrated cellular and wireless networks is a very complex and important issue. Although a number of proposals exist in the literature that present considerable improvement in several aspects, they also present some disadvantages that affect their implementation and deployment. In an attempt to tackle this, we propose a simple distributed algorithm that enables terminals to build prioritised lists of target access network independently for each of their connections. The algorithm also provides specific details on how the core network components can treat each connection based on a number of parameters, which are of paramount importance for the operators. The final choice is a trade-off between the user preferences, the terminal capabilities, the network load and the location and speed of the terminal. The algorithm is designed to provide an easy method for defining user preferences. Finally, we provide an initial evaluation of the signalling load required inside the core network to support the proposed decision making mechanism and make suggestions on the best functional architecture of the radio resource management entities.
Ti O 2 anatase nanolayer on TiN thin film exhibiting high-speed bipolar resistive switching (2006)

The surface oxidized layer of a TiN barrier metal thin film grown on a Pt electrode was used as a resistive switching material. The fabricated memory cell shows bipolar resistive switching on a nanosecond order. A TiO2 anatase layer of about 2.5nm thick on TiN thin film was characterized by high-resolution scanning transmission electron microscopy. The results suggested that the high-speed resistive change was derived from the Mott transition in the TiO2 anatase nanolayer, and the obtained results could relate to the formation of filament paths previously reported in binary transition metal oxide thin films exhibiting resistive switching.
Both the 5' untranslated region and the sequences surrounding the start site contribute to efficient initiation of translation in vitro. (1991)

The role of RNA sequences in the 5' leader region between the cap site and initiating AUG in mediating translation was examined in vitro. Hybrid mRNAs were synthesized in which the cognate leader sequence was replaced with either optimized or compromised leader sequences, and translational efficiency was measured for six different coding regions. Translation was most efficient with a leader containing the 5' untranslated region from Xenopus beta-globin and an optimized initiation sequence. Compared with the cognate leaders, this hybrid was observed to increase translation of the various coding regions as much as 300-fold. The translational efficiencies of the different coding regions also varied substantially. In contrast to earlier suggestions that increased leader efficiency results from higher affinity of the leader for a limiting factor, our experiments suggest that increased translation from the beta-globin hybrid leader sequence results from more rapid initiation of translation.
Optical properties of fat emulsions (2008)

We present measurements of the optical properties of six different fat emulsions from three different brands, Clinoleic, Lipovenoes and Intralipid, with fat concentrations from 10% to 30%. The scattering coefficient, the reduced scattering coefficient, and the phase function of each sample are measured for wavelengths between 350 nm and 900 nm. A method for the calculation of the particle size distribution of these fat emulsions is introduced. With the particle size distribution the optical properties of the fat emulsions are obtained with Mie theory. Simple equations for the calculation of the absorption coefficient, the scattering coefficient, the reduced scattering coefficient, the g factor, and the phase function of all measured samples are presented.
Busulfan (1994)

Busulfan is a useful, sufficiently safe drug in the treatment of patients with CML. At higher dosages, busulfan is a fundamental part of myeloablative therapies for patients undergoing BMT. As the pharmacokinetics and metabolism of busulfan is further understood, there is great potential for improving treatment outcome. An assessment of maximal tolerated exposure determined by therapeutic drug monitoring may decrease the incidence and lethality of regimen-related toxicities.
NASA Langley Aerothermodynamics Laboratory: Hypersonic Testing Capabilities (2015)

A description of the NASA Langley Research Center’s Langley Aerothermodynamics Laboratory (LAL) will be presented in the paper, along with descriptions and details of the facility test techniques and recent upgrades. The LAL consists of three hypersonic blowdown wind tunnels covering Mach numbers of 6 and 10 and unit Reynolds number ranges of 0.5 to 8.3 million per foot as well as a 60-ft Vacuum Sphere Test Chamber. LAL facilities are used to study and define the aerodynamic performance and aeroheating characteristics of flight vehicle concepts. Data collected in the facilities have been used for design and optimization, anchoring computational predictions, generation of aerodynamic databases and design of Thermal Protection Systems. Over the years modifications and enhancements have been made to the facility hardware and instrumentation to increase efficiency, data quality, capabilities and reliability to better meet the programmatic requirements. Recent utilization information illustrates the need for the capabilities associated with these facilities. Recent test programs include the Space Shuttle Program, Crew Exploration Vehicle/Orion/Multi-Purpose Crew Vehicle, Hypersonic International Flight Research Experimentation (HIFiRE), Mars Science Laboratory, Hypersonic Inflatable Aerodynamic Decelerator System (HIADS) and X-51 among others and usage has been split between NASA, Commercial Crew, Department of Defense and private company programs. Plans for future improvements to the facility infrastructure and instrumentation will also be presented.
<title>Application of monolithic polycapillary focusing optics in MXRF</title> (1996)

A monolithic polycapillary focusing optic, consisting of hundreds of thousands of small tapered glass capillaries, can collect a large solid angle of x-rays from a point source and guide then through the capillaries by multiple total reflections to form an intense focused beam. Such a focused beam has many applications in microbeam x-ray fluorescence (MXRF) analysis. Two monolithic polycapillary focusing optics were tested and characterized in a MXRF set- up using a microfocusing x-ray source. For the CuK<SUB>(alpha</SUB> ) line, the measured focal spot sizes of these optics were 105 micrometers and 43 micrometers full-width-half-maximum, respectively. When the source was operated at 16W, the average CuK<SUB>(alpha</SUB> ) intensities over the focal spots were measured to be 2.5 X 10<SUP>4</SUP> photons/s/micrometers<SUP>2</SUP> and 8.9 X 10<SUP>4</SUP> photons/s/micrometers<SUP>2</SUP>, respectively. When we compared the monolithic optics to straight monocapillary optics with approximately the same output beam sizes, intensity gains of 16 and 44 were obtained. The optics were applied to the MXRF set-up to analyze trace elements in various samples and a minimum detection limit of about 2 pg was achieved for the transition elements (V, Cr, Mn, and Fe). The optics were also used to map the distributions of trace elements in various samples.
Management of skin disease in lupus. (1997)

In summary, patients with cutaneous lesions of lupus erythematosus should be treated with sunscreens, topical and intralesional corticosteroids, and anti-malarials as standard therapy. The choice of alternative therapy is personal, and discussions of the risks and benefits should be carefully documented. Successful therapy for cutaneous LE is possible in almost all well-motivated, cooperative patients.
Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo (2015)

Our findings demonstrate that these novel human anti-CAIX mAbs have therapeutic potential in the unmet medical need of targeted killing of HIF-driven CAIX(+)RCC. The orthotopic tumor xenografted humanized mouse provides an improved model to evaluate the in vivo anti-tumor capabilities of fully human mAbs for RCC therapy.
Frequency response and tunability of grating-assisted directional couplers (1991)

The spectral properties of grating-assisted directional couplers are studied using an improved coupled mode formulation. Key parameters for the design of these structures, such as the grating period, the coupling length, and other structural parameters, are calculated. The frequency response, the filter bandwidth, and the tuning range are analyzed. The technique is used to examine a specific case of InGaAsP-InP tunable filters, and the results are compared to a prior experiment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Aldo-Keto Reductases and Toxicant Metabolism (2003)

Aldo-Keto Reductases (AKRs) are a rapidly growing gene superfamily involved in the formation of hyperosmotic sugars, which can contribute to diabetic complications. They also metabolize reactive aldehydes, prostaglandins, steroid hormones, chemical carcinogens and drugs. These enzymes (>115) are generally monomeric, cytosolic, NAD(P)H-dependent-oxidoreductases, that share high sequence identity (<40%) and similar three-dimensional-structures e.g., (α/β)8-barrels and belong to 14 families. For a complete listing of the 14 families visit: www.med.upenn.edu/akr. AKRs detoxify endogenous toxicants, e.g., cytotoxic/mutagenic bifunctional electrophiles derived from the decomposition of lipid hydroperoxides. AKRs also metabolize exogenous toxic substances. They play a role in tobacco-carcinogenesis since they catalyze the detoxication of nicotine derived nitrosamino-ketones and activate polycyclic aromatic trans-dihydrodiols to yield reactive and redox active ortho-quinones. Discrete isozymes also detoxify mycotoxin metabolites, e.g., aflatoxin dialdehyde and protect against hepatocellular carcinoma. The aflatoxin reductases are induced by cancer chemopreventive agents, e.g., ethoxyquin. Evidence is mounting that AKRs are stress regulated genes and play a central role in the cellular response to osmotic, electrophilic and oxidative stress.
Rapid selection and identification of Miscanthus genotypes with enhanced glucan and xylan yields from hydrothermal pretreatment followed by enzymatic hydrolysis (2012)

High throughput pretreatment and co-hydrolysis (HTPH) rapidly identified promising genotypes from a wide range of Miscanthus genotypes, including hybrids of Miscanthus sacchariflorus/M. sinensis and Miscanthus lutarioriparius, differentiating the more commercially promising species from the rest. The total glucan plus xylan content in Miscanthus appeared to influence both mass and theoretical yields, while lignin and ash contents did not have a predictable influence on performance.
Tumor necrosis factor is required for the priming of peritoneal macrophages by trehalose dimycolate. (1999)

Trehalose dimycolate (TDM), a glycolipid present in the cell wall of Mycobacterium spp., is a powerful immunostimulant. We have developed an original model of macrophage activation where TDM is injected in vivo to prime peritoneal macrophages. These primed macrophages do not express inducible NO synthase (NOS II), however, they can be fully activated, i.e. induced to express NOS II and to develop a NOS II-dependent antiproliferative activity, following in vitro exposure to low concentrations of LPS. In a previous paper, we have shown that TDM-priming of mouse peritoneal macrophages is mediated by the sequential production of IL-12 and IFN-gamma. In the present paper, we investigated the role of TNF in the priming of macrophages by TDM. By semi-quantitative RT-PCR, we have shown that TDM injection induced transcription of TNF-alpha in peritoneal cells. TNF-mRNA levels peaked 5 hours after TDM injection and remained elevated for at least 32 hours. TNF expression was absolutely necessary for macrophage priming, as injection of an anti-TNF monoclonal antibody, 4 h before and 20 hours after TDM injection, prevented LPS-dependent activation of macrophages in vitro. This result was confirmed by the inability of TDM to prime macrophages from LT-alpha/TNF-alpha knockout (LT/TNFKO) mice. In addition, analysis of LT/TNFKO mice treated with TDM revealed that induction of the IL-12 transcript in their peritoneal cells and expression of a functional NADPH oxidase in macrophages are TNF-independent events.
Disinfection of swimming pool water (2003)

Results from this study, which has investigated the impact of the treatment technologies of chlorination, ozonation and UV irradiation on pool water quality are reported. The aim of the study was to evaluate the effect of these technologies in an unbiased way using a unique protocol, and to calculate a mass balance across the pool system. Data refer to a protocol based on operation of a 2.2m (cubed) capacity pilot swimming pool, which allows the comparison of technologies applied with reference to the propensity to generate the chlorinated disinfection by-products (DBPs) of chloramines and trihalomethanes (THMs). The protocol makes use of a specially developed body fluid analogue (BFA), containing simulant endogenous organic matter, with a soiling analogue consisting of commercial humic acid (HA). Using this analogue, levels of organic carbon (OC) and chloramines similar to those recorded in real pools have been obtained, along with somewhat lower levels of THMs.\n\nResults revealed conventional chlorination leads to steady-state TOC and DBP levels following an equilibrium period of 200-600 hours, with concentration values which are dependent on BFA loading rate. Following equilibration nitrate is the only DBP accumulating in the pool water, accounting for between 4% and 28% of the ammoniacal nitrogen loaded into the pool depending upon the operating conditions (primarily the Cl:N ratio). Both UV irradiation and ozonation, the latter combined with downstream adsorption, provide a similar efficacy in reducing chloramine levels, with their effect on THM and nitrate formation being highly dependent on the pH level and chlorine dose rate.\n\nThis study builds on previous experimentation by including a more rigorous analysis of ozone-GAC with respect to DBP formation, a unique analysis of UV irradiation and a more comprehensive mass balance calculation of C, Cl and N across the pool. The study has established that no accumulation of carbon takes place in the pool, contrary to postulations made in previous published studies, and that the balance between the chloramines and THM DBPs is significantly affected by the HA loading.
Acute lung injury from mechanical ventilation at moderately high airway pressures (1990)

We have explored adverse pulmonary effects of mechanical ventilation at a peak inspiratory pressure of 30 cmH2O in paralyzed and anesthetized healthy sheep. A control group of eight sheep (group A) was mechanically ventilated with 40% oxygen at a tidal volume of 10 ml/kg, a frequency of 15 breaths/min, a peak inspiratory pressure less than 18 cmH2O, and a positive end-expiratory pressure of 3-5 cmH2O. During the ensuing 48 h, there were no measurable deleterious changes in lung function or arterial blood gases. Another 19 sheep were ventilated with 40% oxygen at a peak inspiratory pressure of 30 cmH2O under a different set of conditions and were randomly assigned to two groups. In group B, the respiratory rate was kept near 4 breaths/min to keep arterial PCO2 in the normal range; in group C, the frequency was kept near 15 breaths/min by including a variable dead space in the ventilator circuit to keep arterial PCO2 near baseline values. There was a progressive deterioration in total static lung compliance, functional residual capacity, and arterial blood gases. After some hours, there were abnormal chest roentgenographic changes. At time of death we found severe pulmonary atelectasis, increased wet lung weight, and an increase in the minimum surface tension of saline lung lavage fluid.
ChemInform Abstract: The Properties of Locked Methanocarba Nucleosides in Biochemistry, Biotechnology, and Medicinal Chemistry (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
RETRACTED: In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling (2017)

The blood-brain barrier (BBB) is composed of four cell populations, brain endothelial cells (BECs), pericytes, neurons, and astrocytes. Its role is to precisely regulate the microenvironment of the brain through selective substance crossing. Here we generated an in vitro model of the BBB by differentiating human induced pluripotent stem cells (hiPSCs) into all four populations. When the four hiPSC-derived populations were co-cultured, endothelial cells (ECs) were endowed with features consistent with BECs, including a high expression of nutrient transporters (CAT3, MFSD2A) and efflux transporters (ABCA1, BCRP, PGP, MRP5), and strong barrier function based on tight junctions. Neuron-derived Dll1, which activates Notch signaling in ECs, was essential for the BEC specification. We performed in vitro BBB permeability tests and assessed ten clinical drugs by nanoLC-MS/MS, finding a good correlation with the BBB permeability reported in previous cases. This technology should be useful for research on human BBB physiology, pathology, and drug development.