gebhart/patrepeval huggingface dataset:
A 150 MIPS/W CMOS RISC processor for PDA applications (2002)

This CMOS microprocessor has performance of about 45MIPS at 50 MHz with about 300 mW power dissipation at 3.3 V power supply. It implements about 440 k transistors in a 25 mm/sup 2/ die fabricated by 0.41 /spl mu/m double metal CMOS. It is designed as a core processor for PDA applications, that require high speed graphical operation and digital signal processing functions as well as low power consumption from portability requirements.
Hepatitis B virus reverse transcriptase: diverse functions as classical and emerging targets for antiviral intervention (2013)

Hepatitis B virus (HBV) infection remains a global health problem with over 350 million chronically infected, causing an increased risk of cirrhosis and hepatocellular carcinoma. Current antiviral chemotherapy for HBV infection include five nucleos(t)ide analog reverse transcriptase inhibitors (NRTIs) that all target one enzymatic activity, DNA strand elongation, of the HBV polymerase (HP), a specialized reverse transcriptase (RT). NRTIs are not curative and long-term treatment is associated with toxicity and the emergence of drug resistant viral mutations, which can also result in vaccine escape. Recent studies on the multiple functions of HP have provided important mechanistic insights into its diverse roles during different stages of viral replication, including interactions with viral pregenomic RNA, RNA packaging into nucleocapsids, protein priming, minus- and plus-strand viral DNA synthesis, RNase H-mediated degradation of viral RNA, as well as critical host interactions that regulate the multiple HP functions. These diverse functions provide ample opportunities to develop novel HP-targeted antiviral treatments that should contribute to curing chronic HBV infection.
Luteolin-7-glucoside Promotes Human Epidermal Stem Cell Proliferation by Upregulating<i>β</i>-Catenin, c-Myc, and Cyclin Expression (2019)

Skin epidermal stem cells (EpSCs) play critical roles in skin homeostasis and the repair of skin injury. Luteolin-7-glucoside (L7G) has been reported to accelerate skin wound healing through its anti-inflammatory and antioxidative activity. But its effect on EpSCs is not clear. In the present study, we examined the effect of L7G on the proliferation of human EpSCs and explored the mechanisms involved. MTT assay showed that L7G promoted EpSC proliferation in a dose- and time-dependent manner. BrdU incorporation assay and Ki67 immunofluorescence staining confirmed the proproliferative effect of L7G on EpSCs. Cell cycle analysis showed that treatment of EpSCs with L7G decreased the cell number in the G1 phase and increased the cell number in the S phase. In addition, L7G significantly enhanced EpSC migration. Mechanistic studies showed that L7G significantly induced the expression of <i>β</i>-catenin and c-Myc, as well as cyclins D<sub>1</sub>, A<sub>2</sub>, and E<sub>1</sub> which are critical for G1/S phase transition. L7G stimulated EpSC proliferation through <i>β</i>-catenin and c-Myc. We further examined the effect of L7G on EpSC proliferation in skin tissues by treatment of human skin explants with L7G and examined the number of EpSCs by immunohistochemical stain of EpSC markers <i>α</i> <sub>6</sub> integrin and <i>β</i> <sub>1</sub> integrin. We found that treatment of human skin tissue explants with L7G significantly increased the thickness of the epidermis and increased the numbers of <i>α</i> <sub>6</sub> integrin-positive and <i>β</i> <sub>1</sub> integrin-positive cells at the basal layer of the epidermis. Taken together, these results indicate that L7G promotes EpSC proliferation through upregulating <i>β</i>-catenin, c-Myc, and cyclin expression. L7G can be used to expand EpSCs for generating epidermal autografts and engineered skin equivalents.
PREPARATION AND CHARACTERIZATION OF FOUR ARMED STAR POLYLACTIC ACID WITH PORPHYRIN CORE (2012)

Star poly(lactic acid) was successfully synthesized via bulk ring opening polymerization of lactide using meso-tetra(p-aminophenyl) porphyrin (TAPP) as initiator and stannous octanoate (Sn(Oct)(2)) as catalyst under vacuum. Molecular structure of the four armed poly (lactic acid) was characterized via H-1-NMR and FTIR. It was confirmed that the star poly(lactic acid) was comprised with four-armed polymer chain and a tin porphyrin core. The molecular weight was also studied via GPC and H-1-NMR, and molecular weight distribution was also characterized (M-w/M-n = 1.97). Both star poly (lactic acid) film and linear poly (lactic acid) film were prepared using solution-casting method. Structural analysis via X-ray diffraction indicates that the star poly(lactic acid) films display the orthorhombic alpha-crystalline form, while linear poly(lactic acid) films display amorphous structure. The photoelectron study of the functional poly(lactic acid) via UV-Vis absorption spectra reveals that the star poly(lactic acid) displays photoelectric property of tin porphyrin.
A ultra-compact 77-GHz CMOS bandpass filter using grounded pedestal stepped-impedance stubs (2011)

This paper presents a compact 77-GHz CMOS bandpass filter suitable for single chip integration with an RF transceiver. The CMOS bandpass filter is mainly composed of an open resonator loaded with two grounded pedestal stepped-impedance stubs to enhance the band selectivity and reduce the chip size. The grounded pedestal is constructed from the vertical stack of the multiple metal layers of the CMOS structure such that the slow-wave effect is present when inserting it beneath the microstrip signal trace. Hence the effective guided-wavelength is shortened. By using this technique, a bandpass filter at 77 GHz was designed. The chip size is as small as 0.31×0.26 mm<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup>, the measured insertion loss is 3.9 dB and the return loss is better than 20 dB in 75 to 84 GHz. Two transmission zeros at 61 GHz and 109 GHz dramatically enhance the band selectivity.
DIABETIC RATS TRANSPLANTED WITH ADULT PORCINE ISLETS AND IMMUNOSUPPRESSED WITH CYCLOSPORINE A, MYCOPHENOLATE MOFETIL, AND LEFLUNOMIDE REMAIN NORMOGLYCEMIC FOR UP TO 100 DAYS1 (2001)

Well-functioning APIs can be isolated in large numbers. API xenografts can be protected from rejection and can maintain an adequate function for up to 100 days, in rats immunosuppressed with CsA+MMF+LEF.
Unmasking antigen determinants in amyloid. (1986)

Rehydrated paraffin sections of formalin-fixed, amyloid-containing tissues were treated with denaturing agents (guanidine and urea) and reducing agents (DDT and mercaptoethanol) before immunostaining, in an attempt to expose antigenic determinants hidden in the rigid structure of amyloid fibrils. Pre-treatment overnight with 6 M guanidine or urea was found beneficial, especially in specimens from familial amyloid polyneuropathy of the Portuguese type. Addition of reducing agents had no major effect. Modifications of this method may be useful in unmasking other antigens that are polymerized or considered destroyed by fixation and paraffin embedding.
The Library of Congress, its architecture and decoration (1982)

Traces the Library's history, shows the building's design, and describes its architectural details and ornaments.
Dry Gas Seal Contamination During Operation and Pressurized Hold - Background and Potential Solutions (2016)

Glenn Schmidt is a DGS Consultant to the industry today.Before he was the EagleBurgmann Regional Product Specialist supporting the Americas region with technical and sales support for designing, servicing, repairing, troubleshooting and upgrades of compressors gas seals and systems.His 16-years of experience with gas seals includes instructing a
Lactulose inhibits endotoxin induced tumour necrosis factor production by monocytes. An in vitro study. (1990)

Preoperative oral treatment with lactulose is used to prevent complications after surgery in patients with obstructive jaundice. The effect is perhaps the result of an inactivation of gut derived endotoxins but the exact mechanism of action is, however, unknown. Tumour necrosis factor is an important mediator of endotoxin toxicity. The cytokine tumour necrosis factor is mainly produced by mononuclear phagocytes. In this study, the effect of lactulose on the endotoxin induced tumour necrosis factor release by monocytes was investigated. The direct effect of lactulose on endotoxin was tested in a chromogenic limulus amoebocyte lysate assay. Polymyxin B a known inactivator of endotoxin was used as control in both experiments. Lactulose has a limited capacity to inactivate endotoxin as measured in the endotoxin assay. In contrast lactulose significantly reduced endotoxin induced tumour necrosis factor production by monocytes. In conclusion lactulose inhibits tumour necrosis factor production by a direct inhibitory effect on monocytes, rather than by inactivation of endotoxin. Because tumour necrosis factor is an important mediator of endotoxin toxicity, this inhibitory effect could explain the beneficial effect of lactulose in obstructive jaundice.
Closing the Gap Between Reservoir Simulation and Production Optimization (2007)

Abstract The operation of oil and gas fields requires that a multilevel decision hierarchy is used to address field optimization at all timescales. These decisions affect production volumes and costs, not only in their short-term outcomes but also over the life of the field. Depending on the time scale, several models with varying degrees of complexity and detail are typically used to characterize the reservoir (e.g. material balance, full-physics model, and decline curve). However, the strategy to integrate and maintain these separate reservoir models (describing the same field) is often ad hoc and inconsistent. To make predictions suitable for short-term decisions, proxy-models (e.g. neural networks, response surface) have been proposed. However, these black-box models do not consider the underlying physics of the reservoir phenomena and are limited to the effects captured in the training data set. In this paper, we build upon our earlier work [1] on integration of full-field strategic models (physics-based) and short range operational models based on the moving-horizon, parametric identification approach for reservoir simulation. A short-range, reduced-order model structure is developed, and the model parameters are obtained from production history data. Because the model structure is motivated by the decomposition of a full-physics model, it is expected to be feasible to extrapolate outside the range of history data. The reduced-order model also increases the computational efficiency and effectiveness in carrying out the simulation objectives. The benefit of the proposed model is to assist in the short-term decision making in production operations. This paper provides a discussion of the methodology for identifying such physics-based parametric models for production operation workflows. It also presents case studies to illustrate the benefits of this method for real time production operations and closed-loop reservoir management.
Suppression of Mosquito Noise by Recursive Epsilon-Filters (2007)

This work addresses the problem of mosquito noise (MN) reduction in compressed video sequences. A compression-blind approach is adopted; the advantage of such an approach is that it is independent of the particular compressor used and of its particular settings. A recursive filtering scheme is presented. It is shown how the filtering parameter ϵ can be adaptively selected to maximize the denoising performance by minimizing the number of outlier pixels in the filter's support. Simulation results show that the proposed blind MN-denoising scheme outperforms existing MN-denoising methods.
Association Between Chemical Composition of Seed and Seed Yield of Soybeans<sup>1</sup> (1972)

Soybean [ Glycine max (L.) Merrill] lines selected for differences in oil percentage from BC 1 and BC 2 populations were evaluated for seed yield, oil percentage, and protein percentage. Selection on the basis of oil percentage was effective in obtaining lines distinctly different in protein percentage. High‐protein lines averaged lower yields than did high‐oil lines. All BC 1 lines averaged lower in seed yield than BC 2 lines. Evidence is presented to show that factors other than chemical composition have influenced the seed yield level of the lines selected.
Effect of Tl and Metallic Element Addition to In–Se Based Phase-change Optical Recording Film (1987)

The mechanism of fast crystallization of In-Se phase-change optical recording films by Tl addition is studied determining atomic arrangement by XPS and using crystallization kinetics of a written amorphous state. Thallium ions in the In-Se-Tl film found to be monovalent, so they cut atomic bonds. The minimum crystallization time by an laser-beam irradiation is shorten to 0.2µs by the Tl addition. The Tl addition increases both the activation energy and frequency factor for crystallization. Cobalt addition to the In-Se-Tl film not only stabilizes amorphous state but also makes erasing faster. The minimum crystallization time is further shorten to 0.06 µs. The retention time of written dot's amorphous state is estimated to be 100 years at 150°C. More than 2500 times of single-beam overwrite is achieved using In-Se-Tl-Co disk. Carrier to noise ratio of a 2.5MHz signal is 54dB at 1800rpm.
Feedback linearization control of magnetorheological fluid damper based systems with model uncertainty (2004)

This paper is concerned with the effects of magnetorheological (MR) fluid damper model uncertainties on system stability, when local feedback linearization schemes are utilized to stabilize an inherently unstable system with negative damping. The objectives of the research are to characterize such effects, and develop a robust control law for given uncertainty bounds. First, for the purpose of discussion, sine functions are used as examples to represent the possible deviations between the actual MR damper force and the force predicted by the model. The limit cycle behavior is predicted using the describing function method and parameters influencing the limit cycle characteristics are identified. An effort is then made to identify the worst-case model deviation, given the bounds on the possible model uncertainties. Based on these results and the limit cycle analysis, the minimum control gain to eliminate the limit cycle instability can be derived. With such gains, the closed-loop system is robust against all uncertainties within the bounds.
COMPREHENSIVE HEALTH SERVICES FOR CHILDREN: AN EXPLORATORY STUDY OF BENEFIT (1973)

This study explores the benefit of a Health Center offering comprehensive health servicces to children by examining the effect of these services on school absenteeism. Average school absenteeism for the 991 children in the study group increased from 10.4 to 13.7 days respectively, for the school years prior to and about two years after the opening of the Center. No statistically significant relationship could be demonstrated between different levels of use of services at the Health Center and changes in absenteeism during the study. Several alternative explanations of these results are proposed. Further studies of outcomes of comprehensive health care are needed if medical planners are to be able to allocate resources effectively.
Rational Drug Design of G-Quartet DNA as Anti-Cancer Agents (2005)

The ability of certain DNA sequences to form G-quartet structures has been exploited recently to develop novel anti-cancer agents including small molecules that promote G-quartet formation within the c-MYC promoter thereby repressing c-MYC transcription and introducing G-quartet-forming oligodeoxynucleotides (GQ-ODN) into cancer cells resulting in p53-dependent cell cycle arrest and inhibition of DNA replication. GQ-ODNs also have been developed as potent inhibitors of signal transducer and activator of transcription (STAT) 3, a critical mediator of oncogenic signaling in many cancers. This review summarizes the rational design of G-quartet forming DNA drugs as Stat3 inhibitors. Topics that are reviewed include the strategy of structure-based drug design, establishment of a structure-activity relationship, development of a novel intracellular delivery system for G-quartet-forming DNA agents and in vivo drug testing to assess the anti-cancer effects of DNA drugs in tumor xenografts. Results to date with GQ-ODN targeting Stat3 are encouraging, and it is hoped that continued pursuit of the methodology outlined here may lead to development of an effective agent for treatment of metastatic cancers, such as prostate and breast, in which Stat3 is constitutively activated.
Causality Testing: A Data Compression Framework (2017)

Causality testing, the act of determining cause and effect from measurements, is widely used in physics, climatology, neuroscience, econometrics and other disciplines. As a result, a large number of causality testing methods based on various principles have been developed. Causal relationships in complex systems are typically accompanied by entropic exchanges which are encoded in patterns of dynamical measurements. A data compression algorithm which can extract these encoded patterns could be used for inferring these relations. This motivates us to propose, for the first time, a generic causality testing framework based on data compression. The framework unifies existing causality testing methods and enables us to innovate a novel Compression-Complexity Causality measure. This measure is rigorously tested on simulated and real-world time series and is found to overcome the limitations of Granger Causality and Transfer Entropy, especially for noisy and non-synchronous measurements. Additionally, it gives insight on the `kind' of causal influence between input time series by the notions of positive and negative causality.
Fuzzy logic based smoothing control of wind/PV generation output fluctuations with battery energy storage system (2011)

The battery energy storage system (BESS) is the current typical means of smoothing intermittent wind or solar power generation. Such BESS hybrid power systems require a suitable control strategy that can effectively regulate power output levels and battery state of charge (SOC); otherwise, a problematically large energy storage capacity is necessary. This paper presents the results of a wind/PV/BESS hybrid power system simulation analysis undertaken to improve the smoothing performance of wind and PhotoVoltaic (PV) power generation and the effectiveness of battery SOC control. A fuzzy-logic-based power smoothing method is presented for reducing output power fluctuations of wind/PV hybrid power generation systems and regulating the battery SOC under the typical conditions. The effectiveness of the proposed method was verified using MATLAB/SIMULINK software.
Polymersome Stomatocytes: Controlled Shape Transformation in Polymer Vesicles (2010)

We report here a controllable shape transformation of polymer vesicles (polymersomes) constructed from block copolymers of which the hydrophobic part is a high-molecular-weight glassy segment. Control over the shape transformation is obtained by kinetic manipulation of the phase behavior of this glassy hydrophobic segment. Kinetic manipulation of the phase behavior of polymer membranes allows for different shapes of polymersomes to be captured at specific times, which directly translates into physically robust nanostructures that are otherwise unobtainable. Combining the morphological diversity of giant liposomes and the physical robustness of polymersomes, our finding can be a general way to realize unusual nanostructures in a predictable manner.
RELATIONSHIP BETWEEN SYNAPTOSOMAL CALCIUM UPTAKE AND ANTINOCICEPTIVE ACTION OF MORPHINE (1983)

We studied the relationship between inhibition of 45Ca2+ uptake and the antinociceptive action induced by morphine and effects of papaverine and 1,1-diphenyl-3-piperidinobutanol hydrochloride (Aspaminol) on both these actions of morphine.Addition of these drugs in the incubation medium significantly inhibited glutamate-stimulated synaptosomal 45Ca2+ uptake. The inhibition curves of morphine and Aspaminol on glutamate-stimulated synaptosomal 45Ca2+ uptake were linear, but that of papaverine was not. The inhibition of morphine on synaptosomal 45Ca2+ uptake was reversed by addition of naloxone. The inhibition of synaptosomal 45Ca2+ uptake induced by morphine was increased by the simultaneous addition of Aspaminol, but the inhibition induced by both morphine and papaverine was not increased to more than that by papaverine alone. Since morphine-antinociception was potentiated by Aspaminol and blocked by papaverine, these results support that the inhibition of synaptosomal calcium uptake plays an important role in the production of morphine-antinociception. However,since the inhibition of synaptosomal 45Ca2+ uptake by morphine was less than that by both Aspaminol and papaverine, and papaverine blocked morphine-antinociception,notwithstanding that 10−4 M of papaverine alone completely inhibited glutamate-stimulated 45Ca2+ uptake into synaptosomes, it may be difficult to account for the antinociceptive action of morphine by the inhibition of 45Ca2+ uptake only.
A New Model Describing the Swelling and Drug Release Kinetics from Hydroxypropyl Methylcellulose Tablets (1999)

A novel mathematical model for the water transport into and drug release from hydroxypropyl methylcellulose (HPMC) tablets is presented. Fick's second law of diffusion is used to describe the mass transfer processes in the three-component system drug/polymer/water. Numerical solutions of the respective set of partial differential equations are provided, considering axial and radial diffusion within cylindrical tablets. It is shown that the diffusion coefficients strongly depend on the water concentration (parameters quantifying this dependence have been determined). Swelling of the device is considered using moving boundary conditions, whereas dissolution processes are neglected. Experiments proved the applicability of the theory. The practical benefit of the new model is to calculate the required shape and dimensions of HPMC tablets to achieve a desired release profile.
π-Olefin-Iridium-Komplexe, IX [1] Bis(η<sup>4</sup>-butadien)-σ-organyl-iridium-Verbindungen / π-Olefin Iridium Complexes, IX [1] Bis(η<sup>4</sup>-butadiene)-cr-organyl-iridium Compounds (1982)

Complexes of the type [L 2 IrR] (L = butadiene, isoprene, piperylene, 1,4- and 2,3- dimethylbutadiene; R = CH 3 , C 6 H 5 ) have been synthesized by reactions of [L 2 IrCl] with LiR in hexane. With L = 2,3-dimethylbutadiene, [L 2 IrR] compounds with higher alkyl groups R (e.g. η-C 3 H 7 , η-C 4 H 9 ) can be obtained which for steric reasons are inert against β-elimination. The system [L 2 IrCl]/L/LiAlH 4 (L = 2,3-dimethylbutadiene) yields [L 2 IrR] with R = 2,3-dimethylbutene-2-yl. The complexes were characterized by NMR and mass spectra
Factors Affecting the Anisotropic and Dynamic Scattering Characteristics of an Ester Mixture (1984)

Abstract Various factors affecting the anisotropic and dynamic scattering (DS) characteristics of a 3-component eutectic mixture of phenyl benzoates are investigated in detail. The effects of dopant, surface alignment, signal, cell thickness, and temperature are studied. Different dopant structures give conductivity anisotropy values in the 1.01 to 1.60 range and this has the largest effect on the DS threshold voltage at room temperature. However, cell thickness also changed the threshold slightly and has a large effect on the magnitude of the scattering obtained above threshold. Thinner cells give higher DS levels, higher multiplexing capabilities, and greater offangle scattering. The optical density of scattering increases linearly with the reciprocal of cell thickness. At elevated temperatures the conductivity anisotropy, viscosity and elastic constant values all decrease. However, with the increasing temperature the DS threshold voltage decreases, indicating that changes in viscosity and elastic constants with temperature are more significant than the decrease in conductivity anisotropy.