gebhart/patrepeval huggingface dataset:
Interactions of active-site residues and catalytic activity of human carbonic anhydrase III. (1994)

To elucidate the interactions between residues found in the active-site cavity of human carbonic anhydrase III, we have prepared a series of single and double mutants with Lys-64, Arg-67, and Phe-198 replaced with Ala, Asp, Glu, His, and Leu. Rates of catalysis were determined using 18O exchange between CO2 and water measured by mass spectrometry and initial velocity measured by stopped-flow spectrophotometry. Replacement of these residues resulted in increases in kcat/Km for CO2 hydration as much as 200-fold and increases in the pKa of the zinc-bound water by as much as 3.5 units. We conclude that the effect of replacements made at positions 64, 67, and 198 were in general additive for kcat/Km for CO2 hydration, indicating that there is no interaction between these sites that affects the catalytic interconversion of CO2 and HCO3-. One notable exception is the antagonism exhibited by the double mutant of human carbonic anhydrase III containing Glu-64 and Leu-198. The data also show that one source of the large enhancement of kcat/Km for the mutant containing Asp-198 in human carbonic anhydrase III is the presence of both Asp-198 and Lys-64; when Lys-64 was replaced with Ala, a reduction of catalytic activity was observed. These results provide an additional view of the independent interactions of amino acids that affect the catalytic pathway of isozyme III, the least active of the known carbonic anhydrase isozymes.
Impact of Environmental Pollution on Human Health of the Population Which Lives Nearby Kosovo Thermopower Plants (2011)

This study describes an investigation of effects of environmental pollution as a result of outflow from the coal processing industry. Coal is one the largest deposits of fossil inorganic material where metal accumulations have been observed. The trace elements in coal that could have an undesirable environmental impact include: Hg, Pb, Be, Se, As, Cd, Cu, Ni, Zn, Cr, Ge, Mn, V and Co. Dust consisting of fly ash and bottom ash is one the main components of the environmental pollution that is released from the industrial area of thermopower plants of ‘‘Kosova’’. Analysis of the emission of the fly ash from thermopower plants of ‘‘Kosovo’’ during 2005 showed that contamination had exceeded EU standards by 400—500%. In a comparative study of biochemical parameters in blood of human population of two different environments in Kosovo, one done near by the Kosovo thermopower plants in Obiliç, a highly polluted environment investigated group and the other that is considered as a relatively clean rural environment in Dragash, control group. Based on the results achieved in this study, it can be concluded that the pollution emitted from Kosovo thermopower plants by releasing fly ash and bottom ash to the environment has a direct effect on human health of the population living in the industrial area of Obiliç.
DIOPS: A PC-Based Wave, Tide and Surf Prediction System (2005)

Abstract : The Distributed Integrated Ocean Prediciton System (DIOPS) is a PC-based wave tide and surf prediction system designed to provide DoD accurate and timely surf predictions for essentially any world-wide location. Regional and coastal wave predictions are made by the Simulating Waves Nearshore (SWAN) wave module that is typically initialized by offshore directional wave spectra from the Fleet Numerical Meteorological and Oceanography Center (FNMOC). Tide and storm surge predictions are made by PCTIDES, a relocatable 2-D barotropic ocean model that can assimilate tidal constituent data. A one-dimensional surf model, SURF3.2 generates surf predictions based on wave and tidal information from SWAN and PCTIDES. Wind forcing obtained from FNMOC is used to force all DIOPS models. Water levels from PCTIDES are used to adjust bathymetry in the wave and surf modules. The Dynamic Information Architecture System developed by Argonne National Laboratory provides the object-oriented framework that allows the models to exchange information with each other. DIOPS has been loosely coupled with the Delft3D modeling system for 2-dimensional surf predictions to give the U.S. Navy a new capability to predict the location of rip-tides, provided high-resolution (scales of meters) bathymetry is available.
PUGeo-Net: A Geometry-centric Network for 3D Point Cloud Upsampling (2020)

This paper addresses the problem of generating uniform dense point clouds to describe the underlying geometric structures from given sparse point clouds. Due to the irregular and unordered nature, point cloud densification as a generative task is challenging. To tackle the challenge, we propose a novel deep neural network based method, called PUGeo-Net, that learns a $3\times 3$ linear transformation matrix $\bf T$ for each input point. Matrix $\mathbf T$ approximates the augmented Jacobian matrix of a local parameterization and builds a one-to-one correspondence between the 2D parametric domain and the 3D tangent plane so that we can lift the adaptively distributed 2D samples (which are also learned from data) to 3D space. After that, we project the samples to the curved surface by computing a displacement along the normal of the tangent plane. PUGeo-Net is fundamentally different from the existing deep learning methods that are largely motivated by the image super-resolution techniques and generate new points in the abstract feature space. Thanks to its geometry-centric nature, PUGeo-Net works well for both CAD models with sharp features and scanned models with rich geometric details. Moreover, PUGeo-Net can compute the normal for the original and generated points, which is highly desired by the surface reconstruction algorithms. Computational results show that PUGeo-Net, the first neural network that can jointly generate vertex coordinates and normals, consistently outperforms the state-of-the-art in terms of accuracy and efficiency for upsampling factor $4\sim 16$.
Individualized Prescription of Peritoneal Dialysis Therapy (1999)

Prescribing PD has become more challenging, but also more rewarding and stimulating in recent years. The number of technical aids and strategies has increased, and a potential exists to optimize clearances and ultrafiltration in a way that has not been seen before and that will, it is to be hoped, translate into better patient outcomes. It is crucial, however, that the technologies and strategies be applied with an awareness of the individual patient's particular lifestyle, aspirations, and social circumstances. A failure to consider these factors may lead to noncompliance and, ultimately, to "burnout" and technique failure. Patients must be educated about the importance of clearance targets so that they will accept the alterations in, or the onerous aspects of, the prescriptions they require. Successful prescribing of PD requires an awareness of both clearance and lifestyle factors so that the two can be integrated to give an effective and acceptable regimen. Finally, cost factors should also be considered.
Salvage effect of E5564, Toll‐like receptor 4 antagonist on d‐galactosamine and lipopolysaccharide‐induced acute liver failure in rats (2009)

TLR4 antagonist E5564 reduced GalN+LPS-induced acute liver injury in rats and improved the overall survival rate of GalN+LPS-induced ALF rats. It may contribute to the treatment of ALF through blocking endotoxin-induced TNF-alpha overproduction of macrophages.
MicroRNAs in the cancer clinic (2012)

Over recent years there have been major advances in our understanding of tumour biology which have led to improved diagnostic and prognostic techniques and the development of novel targeted therapies. However the reliability of such biomarkers is questionable and the efficacy of new treatments remains predominantly limited by a combination of drug resistance, toxicity and persisting insufficiencies in our comprehension of tumour-signalling pathways. Following their recent discovery, microRNAs (miRNAs) have been established as key regulators of gene-expression, and their putative roles as oncogenes and tumour suppressor genes has provided a potentially new dimension to our clinical approach to cancer diagnosis and treatment. Their role as biomarkers and therapeutic targets is appealing but several obstacles have as yet limited our ability to translate this potential into a clinical reality. This review focuses on currently accepted roles of miRNAs in cancer pathogenesis, and highlights the challenges and breakthroughs in this field to date with relevance to the cancer clinic.
Fine control of the porous structure and chromatographic properties of monodisperse macroporous poly(styrene‐co‐divinylbenzene) beads prepared using polymer porogens (1994)

Abstract The porous structure of monodisperse macroporous beads can be controlled by using soluble polymers with well‐defined structural characteristics as part of the porogenic mixture. In general, the use of linear polystyrene as a porogen in the preparation of poly (styrene‐co‐divinylbenzene) beads shifts the pore size distribution towards larger pores. While a direct correlation between pore size and molecular weight of the porogen has been established, the chemical composition of the polymer porogen has no effect on the porous and chromatographic properties of the beads. These findings suggest that the average molar volume of the porogenic system is important while the miscibility of the polymer porogen with the crosslinked polymer that is formed is of little relevance. © 1994 John Wiley & Sons, Inc.
Addition of Alcohols to Fluorinated Ethylenes (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition of Alcohols to Fluorinated EthylenesARIEH DEMIELCite this: J. Org. Chem. 1960, 25, 6, 993–996Publication Date (Print):June 1, 1960Publication History Published online1 May 2002Published inissue 1 June 1960https://pubs.acs.org/doi/10.1021/jo01076a033https://doi.org/10.1021/jo01076a033research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hypoparathyroidism after Roux-en-Y gastric bypass - a challenge for clinical management: a case report (2014)

The use of exogenous pancreatic enzymes improved calcium homeostasis in this bariatric patient. The role of these enzymes on vitamin D absorption and subsequent rise in calcium levels in hypoparathyroid patients who undergo bariatric procedures need further investigation.
Aldosterone responses to hyperkalemia in healthy elderly humans. (1995)

Plasma aldosterone levels are reported to be lower in healthy elderly individuals compared with young individuals, a difference exaggerated by sodium depletion or upright posture. The aim of this study was to determine the aldosterone response to increases in serum potassium with advancing age. In the Clinical Research Center, six healthy young (20 to 35 yr of age) and six healthy elderly (65 to 85 yr of age) subjects underwent evaluation of their aldosterone responses to potassium infusion (0.5 mEq/kg over 45 min). Both young and elderly subjects had similar basal serum potassium levels (4.3 +/- 0.2 versus 4.4 +/- 0.1 mEq/L), similar sodium and potassium excretion amounts and similar increase in serum potassium levels during infusion (to 5.0 +/- 0.2 versus 5.1 +/- 0.1 mEq/L). However, elderly subjects had lower basal levels of plasma aldosterone and a blunted aldosterone response to potassium infusion (P < 0.05, analysis of variance). Advancing age is characterized by relative hypoaldosteronism in the basal state as well as in response to hyperkalemia. This may contribute to an increased susceptibility to hyperkalemia if other potassium regulatory systems fail.
Real time failure analysis of Cu interconnect defectivity through bitmap overlay analysis (2003)

Bitmap to in-line defect overlay analysis was performed on a 4 Mbit SRAM memory array, which uses copper interconnect. This analysis provides an effective method of identifying killer copper defects, which inhibit product yield. It has been shown that bitmap overlay (BMOL) analysis is a very effective way of identifying killer defects for any technology at any process step. This can be proven to be a very powerful tool to relate physical defectivity to significant yield loss mechanisms. It has been shown that BMOL can be used to assign a root cause mechanism or a defect to an actual electrical fail without incurring tedious hours of destructive failure analysis. Failure analysis was, however, used to initially verify and confirm root cause of the electrical failures identified by BMOL analysis.
Shakespeare. (1954)

Henri Fluchere, Guy Hamilton and T. S. Eliot, Shakespeare Get access Shakespeare. By Henri Fluchere. Translated by Guy Hamilton. With a foreword by T. S. Eliot. New York: Longmans, Green and Co. 1953. Pp. x + 272. $5.00. Milton Crane Milton Crane Washington, D. C. Search for other works by this author on: Oxford Academic Google Scholar Shakespeare Quarterly, Volume 5, Issue 2, Spring 1954, Pages 186–188, https://doi.org/10.2307/2866591 Published: 01 April 1954
Isolation and Biochemical Characterization of a Basic Myrosinase from Ripe <i>Crambe abyssinica</i> Seeds, Highly Specific for <i>epi</i>-Progoitrin (2003)

On the basis of previous studies on the mechanism-based inhibition, activation, and active site structure of myrosinase(s) isolated from Sinapis alba and other cruciferous seeds, crambe myrosinase shows uncommon properties and behavior. For this reason homogeneous crambe myrosinase was isolated and investigated to establish the most important physicochemical features, including kinetic properties determined with the epimers progoitrin (R) and epi-progoitrin (S) as substrates, with and without ascorbate as an activator. The results of this study demonstrate that crambe myrosinase is highly specific for epi-progoitrin due to a better stabilization of the enzyme-substrate complex. This stabilization is caused by additional hydrogen bonding that only epi-progoitrin can set up between its hydroxyl group and a suitable residue in the hydrophobic pocket where the "docking" of the glucosinolates side chain takes place.
Role of magnesium ions in DNA recognition by the EcoRV restriction endonuclease (2011)

The restriction endonuclease EcoRV binds two magnesium ions. One of these ions, Mg(A)(2+), binds to the phosphate group where the cleavage occurs and is required for catalysis, but the role of the other ion, Mg(B)(2+) is debated. Here, multiple independent molecular dynamics simulations suggest that Mg(B)(2+) is crucial for achieving a tightly bound protein-DNA complex and stabilizing a conformation that allows cleavage. In the absence of Mg(B)(2+) in all simulations the protein-DNA hydrogen bond network is significantly disrupted and the sharp kink at the central base pair step of the DNA, which is observed in the two-metal complex, is not present. Also, the active site residues rearrange in such a way that the formation of a nucleophile, required for DNA hydrolysis, is unlikely.
A model-driven approach to content repurposing (2004)

The multimedia metamodel defines platform-independent multimedia concepts, opening the way for novel approaches to designing content repurposing solutions. Designers can use the metamodel to create content and add metadata to existing content, simplifying content analysis and repurposing. This model-driven approach and proposed design solutions are useful not only for many multimedia designers and researchers, where the model-driven tools can help them create better multimedia interfaces, but also for lecturers and students of multimedia courses. In the latter case, the unified multimedia metamodel offers context for sometimes subtle relationships between multimedia concepts. The metamodel can also facilitate the collaborative creation of broader knowledge about multimedia phenomena. In our future work, we plan to extend the proposed metamodel and include domains from related fields, such as user modeling and intelligent tutoring systems that deal with high-level user models. We are also designing multimodal test environments, reusable multimedia components, and data mining tools for evaluating various aspects of multimedia and multimodal communication.
Mapping of branchpoint nucleotides in mutant pre‐mRNAs expressed in plant cells (1996)

Pre-mRNA encoding rubisco activase in the Arabidopsis thaliana mutant rca contains a GU to AU change at the 5' splice site of intron 3 and this mutation results in accumulation of splicing intermediates bearing an incompletely processed intron. It has been demonstrated that one of the intermediates contains intron 3 in the form of a lariat and the branchpoint nucleotide has been mapped to the A residue at position -32 forming part of the sequence UUGAU. Analysis of a similar GU to AU 5' splice site mutation, present in a synthetic pre-mRNA context expressed in transfected protoplasts of Nicotiana plumbaginifolia, also suggests formation of lariats with branching occurring at A-31. A small fraction (approximately 10%) of this mutant pre-mRNA also underwent the second step of splicing. In addition to the consensus AG, an AU dinucleotide was used as splicing acceptor.
Signature Quadratic Form Distance (2010)

The Signature Quadratic Form Distance is an adaptive similarity measure for flexible content-based feature representations of multimedia data. In this paper, we present a deep survey of the mathematical foundation of this similarity measure which encompasses the classic Quadratic Form Distance defined only for the comparison between two feature histograms of the same length and structure. Moreover, we give the benefits of the Signature Quadratic Form Distance and experimental evaluation on numerous real-world databases.
Quantitative Speciation of Selenium in Soils Using X-ray Absorption Spectroscopy (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative Speciation of Selenium in Soils Using X-ray Absorption SpectroscopyIngrid J. Pickering, Gordon E. Brown, and Tetsu K. TokunagaCite this: Environ. Sci. Technol. 1995, 29, 9, 2456–2459Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/es00009a043https://doi.org/10.1021/es00009a043research-articleACS PublicationsRequest reuse permissionsArticle Views731Altmetric-Citations127LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of a simple broadband microstrip to waveguide transition (2017)

A novel microstrip to waveguide transition fabricated on a single substrate is proposed. The transition is based on a proximity fed E-shaped patch antenna element which allows for double resonances. Thus the bandwidth of the transition can approximately be doubled compared to a transition which utilizes a regular patch element without increasing the transversal dimensions. The influence of the critical patch parameters is discussed. Numerical results show an input reflection coefficient below -15 dB between 15.97 GHz and 16.49 GHz and a minimal insertion loss of 1 dB. The bandwidth is approximately 3.2% at the center frequency of operation (16.23 GHz). Measurement results of the fabricated transition are presented and compared with simulation results.
Tungsten trench etching in a magnetically enhanced triode reactor (1994)

The problem of polymer contamination in W trench etching is studied for fluorocarbon plasmas. Polymer contamination of narrow trenches has been observed on samples where isolated positive-relief structures (mesas) are clean. This effect is linked to sidewall sputtering by ions backscattered at low angles from the substrate: the sidewalls of a mesa are bombarded by reflected ions originating over a larger area of the substrate than the sidewalls of a trench. The presence of a blast of backscattered ions is confirmed (in an SF6/Br2 plasma) by images where sidewalls adjacent to large substrate areas etch isotropically while those in the shadow of an adjacent feature etch anisotropically. Finally, it is shown that ultrathin, durable polymer coatings which protect mesa sidewalls without contaminating nanometer-scale trenches can be formed in a magnetically enhanced, triode etching system using a CF4/O2 source gas: 40 nm wide, 300 nm deep trenches are shown.
A 12-bit 1.74-mW 20-MS/s DAC with resistor-string and current-steering hybrid architecture (2015)

This paper presents a novel segmented hybrid digital-to-analog converter (DAC). It uses a resistor-string as the LSB part for low-power consumption, and uses a current-steering array as the MSB part for high-speed and small size. The LSB and MSB parts are combined by a slew-rate-enhanced class AB output amplifier for high speed. Compared to resistor string DACs, current steering DACs, or resistor-capacitor hybrid DACs, the proposed DAC shows a better tradeoff between power and speed at low power application demanding a sampling clock between 1 MHz and 100 MHz. The prototype is a 12-bit DAC implemented in 0.18-μm CMOS technology with the worst measured DNL/INL of 6.38 LSB / 7.55 LSB. The analogue part power consumption is 1.24 mW and the digital part 0.5mW at 1.35-V power supply at 20-MS/s sampling rate. Its output is single-end buffered voltage with a range of 500 mV. The core area is 0.16 mm2.