gebhart/patrepeval huggingface dataset:
A Novel Dry Chemical Path Way for Diene and Dienophile Surface Functionalization toward Thermally Responsive Metal–Polymer Adhesion (2013)

In this paper, we report a new and easily up-scalable dry chemical method to functionalize with diene and dienophile groups a large range of surfaces, such as metal, polymer, or glass, and we demonstrate the potentiality of this technique to realize thermally responsive adhesion between these materials. A complete and extensive surface chemistry analysis of the grafted surfaces, based on the deposition of an anhydride-rich thin plasma polymer layer by using an atmospheric pressure dielectric barrier discharge (DBD) plasma process, and its subsequent gas phase aminolysis reaction with specific diene or dienophile compound is discussed. The optimization of the assembling condition for these tailored surfaces has led to achieve a Diels-Alder adhesion force up to 0.6 N/mm at ambient temperature, which can be reduced by a factor of 50 when the retro Diels-Alder is ignited at a heating temperature around 200 °C. The study of the failure interface produced after peeling tests is presented and a mechanism of failure is proposed, based on forensic analyses involving surface analytical techniques such as XPS, ToF-SIMS, and SEM combined to AFM analyses for the retrieving of chemical and morphological information.
California state regulations on collecting abalone (1960)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Subband vector excitation coding with adaptive bit-allocation (2003)

A study of the combination of VSC (vector excitation coding) with subband coding is reported. In subband VXC (SBVXC), the burden of redundancy removal is split between the frequency domain and time domain to take advantage of both predictive coding and subband coding techniques. The conventional adaptive bit-allocation method used in subband coding has been generalized for use in SBVXC. Simulated comparisons of several coding schemes, including one comparing SBVXC with the full-band VXC, are presented. Results show that a two-band version of SBVXC can produce fairly clear, intelligible, and natural-sounding synthetic speech at 4.8 kb/s and very high quality speech at 8 kb/s with a reasonable complexity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Catalyzed Asymmetric <i>DielsAlder</i> Reactions of Benzoquinone. Total Synthesis of (−)‐Ibogamine (2002)

Abstract The DielsAlder reaction of 1,4‐benzoquinone with 1,3‐dienes catalyzed by Mikami 's [Ti{( S )‐binol(2−)}Cl 2 ] complex (binol=[1,1′‐binaphthalene]‐2,2′‐diol) gives cycloadducts in good yield and in high enantiomer excess. A model is proposed to explain the observed absolute configuration of cycloadducts, and the reaction is used as the key step in an asymmetric synthesis leading to the alkaloid (−)‐ibogamine.
Characterization of murine lymphocyte IgE receptors by flow microfluorometry. (1984)

A flow microfluorometric technique has been developed to analyze IgE receptors on splenic and mesenteric lymph node mononuclear cells from BALB/c mice. Our data show that 1) the binding of DIBADL cross-linked IgE dimers to IgE receptors is specific in that it is inhibited by monomeric rat and mouse IgE but not by mouse or rabbit IgG or by the monoclonal anti-Fc gamma R antibody 2.4G2, and conversely, the binding of DIBADL cross-linked IgG dimers is inhibited by monomeric IgG or 2.4G2 but not by rat or mouse IgE; 2) the binding of IgE dimers is saturable on cells from uninfected and Nippostrongylus brasiliensis (Nb)-infected mice; 3) IgE dimer binding is detectable on most splenic B lymphocytes from uninfected and Nb-infected mice, but not on T lymphocytes from uninfected mice, and on few, if any, T lymphocytes from Nb-infected mice; 4) Nb infection causes a parallel increase in the percentages of B lymphocytes and cells expressing IgE receptors and Fc gamma R; 5) Nb infection leads to a marked increase in B lymphocyte IgE receptor expression, has little if any effect on IgE receptor affinity, and causes only minor changes in Fc gamma R expression; and 6) in vivo activation of B lymphocytes by a goat antibody to mouse IgD decreases IgE receptor expression considerably, but has a minimal effect on Fc gamma R expression. Thus, there are separate receptors for IgE and IgG on murine B lymphocytes, and the effect of Nb infection or anti-IgD treatment on their expression is different.
Differentiation of 5-hydroxytryptamine2 receptor subtypes using 125I-R- (-)2,5-dimethoxy-4-iodo-phenylisopropylamine and 3H-ketanserin (1989)

The radioligand binding characteristics of 125I-R-(-)4-iodo-2,5-dimethoxyphenylisopropylamine [125I-R-(-)DOI] and 3H-ketanserin were compared in rat and bovine cortical membranes. In rat cortex, 125I-R-(-)DOI labels a relatively low density of binding sites (Bmax = 2.5 +/- 0.2 pmol/gm tissue) with high affinity (KD = 0.63 +/- 0.09 nM). In bovine cortex, specific binding of 125I-R-(-)DOI represents less than 20% of total binding at radioligand concentrations above 0.6 nM, and, therefore, the data cannot be analyzed adequately by Scatchard transformation. By contrast, 3H-ketanserin displays saturable, specific high-affinity binding in both rat cortex (KD = 1.0 +/- 0.1 nM; Bmax = 11 +/- 0.4 pmol/gm tissue) and bovine cortex (KD = 1.2 +/- 0.2 nM; Bmax = 5.3 +/- 0.4 pmol/gm tissue). Ki values for 30 drugs were determined for 125I-R-(-)DOI-labeled sites in rat cortex and 3H-ketanserin-labeled sites in bovine cortex. 5-Hydroxytryptamine (5-HT) displays 250-fold higher selectivity for the 125I-R-(-)DOI-labeled sites (Ki = 3.0 +/- 0.7 nM) than for the 3H-ketanserin-labeled sites (Ki = 750 +/- 50 nM). Structural congeners of R-(-)DOI display 80- to 160-fold higher affinity for the 125I-R-(-)DOI binding site than for the 3H-ketanserin-labeled binding site. d-LSD and putative 5-HT2 antagonists are approximately equipotent at both sites. Significant correlations were found between drug affinities for 125I-R-(-)DOI-labeled sites in rat cortex and putative 5-HT2A sites labeled previously by 77Br-R-(-)DOB (r = 0.93, p less than 0.01), putative 5-HT2B sites labeled by 3H-ketanserin in bovine cortex (r = 0.63, p less than 0.01), and 5-HT1C binding sites that have been characterized by other investigators (r = 0.78, p less than 0.01). No significant correlations were found between drug affinities for 125I-R-(-)DOI-labeled sites in rat cortex and 5-HT1A, 5-HT1B, 5-HT1D, or 5-HT3 sites, as determined by previous investigators. We conclude that 125I-R-(-)DOI labels a novel 5-HT binding site subtype (tentatively designated the 5-HT2A binding site) that is present in rat cortex but is either absent or minimally present in bovine cortex. By contrast, 3H-ketanserin labels both the putative 5-HT2A site in rat cortex as well as a separate, distinct recognition site that is present in both rat and bovine cortex, tentatively designated the 5-HT2B site.
Proteome analysis at the level of subcellular structures (2003)

The targeting of proteins to particular subcellular sites is an important principle of the functional organization of cells at the molecular level. In turn, knowledge about the subcellular localization of a protein is a characteristic that may provide a hint as to the function of the protein. The combination of classic biochemical fractionation techniques for the enrichment of particular subcellular structures with the large‐scale identification of proteins by mass spectrometry and bioinformatics provides a powerful strategy that interfaces cell biology and proteomics, and thus is termed ‘subcellular proteomics’. In addition to its exceptional power for the identification of previously unknown gene products, the analysis of proteins at the subcellular level is the basis for monitoring important aspects of dynamic changes in the proteome such as protein transloction. This review summarizes data from recent subcellular proteomics studies with an emphasis on the type of data that can retrieved from such studies depending on the design of the analytical strategy.
The South South way (2007)

Caliban, Harry Belafonte, Carmen Miranda, Barry McKenzie, Crocodile Dundee, Idi Amin... The southerner appears on the world stage as a comic figure, innocent of social graces. As a type, it confirms the notion of the north as the seat of reason and justice.
Finding small molecules for the ‘next Ebola’ (2015)

<ns3:p>The current Ebola virus epidemic may provide some suggestions of how we can better prepare for the next pathogen outbreak. We propose several cost effective steps that could be taken that would impact the discovery and use of small molecule therapeutics including: 1. text mine the literature, 2. patent assignees and/or inventors should openly declare their relevant filings, 3. reagents and assays could be commoditized, 4. using manual curation to enhance database links, 5. engage database and curation teams, 6. consider open science approaches, 7. adapt the “box” model for shareable reference compounds, and 8. involve the physician’s perspective.</ns3:p>
On ranking and organizing Web query results (2003)

With the explosive growth of the WWW, most searches retrieve a large number of documents. The query results returned have no aggregate structure; thus, it is difficult to forage for relevant pages. We argue that organization of Web query results is essential to the user in terms of usability of query results. In addition, how the query results are organized has a great impact on the ranking scheme and query processing as well as search engine usability for the users. We present various schemes on ranking and organizing Web query results in the scope of the Net Topix search engine project in NEC Research Laboratories in San Jose. We describe three associated tasks: full-text search and initial ranking, post query processing, and query result reorganization for presentation. We discuss our consideration and pros and cons of each design alternative.
Anthropometric techniques based on kinect 3D scanning (2013)

This paper presented a body composition analysis system (BCAS) framework to perform scanning, reconstruction and the measurement by using a Kinect device. In order to quantize point cloud data, the data scanned by Kinect were converted to 3D point cloud data in the physical space, and the quasi-integral method and Monte Carlo method were used to calculate circumference and volume of the relevant parts of the model respectively. Scanning and 3D reconstruction cost 2~3 minutes all together with a smooth and fine result, the accuracy of the dimension measurement is 97.7%, and the accuracy of the volume measurement is 96.8%. The experiments showed the effectiveness of the proposal. And the body model obtained by the system can be widely applied to such occasions as 3D virtual fitting as well.
Interpretation of Divergent Oculomotor Imbalance through Control System Analysis (1988)

Control systems analysis is proposed as a method for understanding the pathophysiology of oculomotor imbalance, thereby permitting better differential diagnosis and more specific treatment. Clinical cases of nonstrabismic divergent deviations, with an emphasis on convergence insufficiency (CI) are presented and explained using conventional optometric diagnostic concepts and fixation disparity (FD) curves with control systems analysis as the central, unifying concept.
1,3-DIMETHYLPIPERIDONE-4 (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,3-DIMETHYLPIPERIDONE-4DAVID R. HOWTONCite this: J. Org. Chem. 1945, 10, 4, 277–282Publication Date (Print):July 1, 1945Publication History Published online1 May 2002Published inissue 1 July 1945https://doi.org/10.1021/jo01180a003Request reuse permissionsArticle Views865Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (411 KB) Get e-Alertsclose Get e-Alerts
100-340GHz Systems: Transistors and Applications (2018)

We examine potential 100-340 GHz wireless applications in communications and imaging and examine the prospects of developing the mm-wave transistors needed to support these applications.
Tunneling Effects on Fine-Structure Splitting in Quantum-Dot Molecules (2010)

We theoretically study the effects of bias-controlled interdot tunneling in vertically coupled quantum dots on the emission properties of spin excitons in various bias-controlled tunneling regimes. As a main result, we predict substantial reduction of optical fine-structure splitting without any drop in the optical oscillator strength for the coupled dots with high tunneling rates. This special reduction diminishes the distinguishability of polarized decay paths in cascade emission processes suggesting the use of stacked quantum-dot molecules as entangled photon-pair sources.
Cerebrovascular dysautoregulation syndrome complex--brain hypoperfusion precedes hypotension and cardiac asystole. (1994)

A 43-year-old male with history of recurrent episodes of syncope, non-sustained wide complex tachycardia and structurally normal heart was studied. Syncope was induced with upright tilt provocation, while monitoring cerebral blood flow velocity with Doppler ultrasound, concurrently with invasive blood pressure, heart rate and rhythm determination. Postural induced cerebral hypoperfusion preceded hypotension and cardiac asystole. Treatment with ephedrine and transdermal scopolamine was effective in preventing symptoms.
Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice (2015)

Alzheimer disease (AD) is characterized by the extracellular accumulation of amyloid β (Aβ), which is accompanied by a robust inflammatory response in the brain. Both of these pathogenic processes are regulated by nuclear receptors, including the liver X receptors (LXRs) and peroxisome-proliferator receptor γ (PPARγ). Agonists of LXRs have been demonstrated previously to reduce Aβ levels and improve cognitive deficits in AD mouse models by inducing the transcription and lipidation of apolipoprotein E (apoE). Agonists targeting PPARγ reduce the microglial expression of proinflammatory genes and have also been shown to modulate apoE expression. Here we investigate whether a combination therapy with both LXR and PPARγ agonists results in increased benefits in an AD mouse model. We found that the LXR agonist GW3965 and the PPARγ agonist pioglitazone were individually able to increase the levels of apoE and related genes, decrease the expression of proinflammatory genes, and facilitate Aβ decreases in the hippocampus. Combined treatment with both agonists provoked a further increase in the expression of apoE and a decrease in the soluble and deposited forms of Aβ. The decrease in plaques was associated with increased colocalization between microglia and plaques. In addition, the PPARγ agonist in the combined treatment paradigm was able to counteract the elevation in plasma triglycerides that is a side effect of LXR agonist treatment. These results suggest that combined LXR/PPARγ agonist treatment merits further investigation for the treatment of AD.
Collinear type II second-harmonic-generation frequency-resolved optical gating for use with high-numerical-aperture objectives (1998)

Ultrashort-pulse lasers are now commonly used for multiphoton microscopy, and optimizing the performance of such systems requires careful characterization of the pulses at the tight focus of the microscope objective. We solve this problem by use of a collinear geometry in frequency-resolved optical gating that uses type II second-harmonic generation and that allows the full N.A. of the microscope objective to be used. We then demonstrate the technique by measuring the intensity and the phase of a 22-fs pulse focused by a 20x, 0.4-N.A. air objective.
Identification of a Discrete Promoter Region of the Human GnRH Gene That Is Sufficient for Directing Neuron-Specific Expression: A Role for POU Homeodomain Transcription Factors (2002)

The human GnRH (hGnRH) gene is expressed, and the GnRH decapeptide produced, primarily in the GnRH neurons of the diencephalon. The molecular elements important for the cell-specific expression and regulation of the hGnRH gene are not well established at this time; therefore, we have used a transgenic mouse model to isolate cis-regulatory elements important for directing gene expression to GnRH neurons in the hypothalamus. Gene constructs consisting of various promoter deletion fragments of the hGnRH gene fused to the luciferase (LUC) reporter gene have been used to create transgenic mouse lines. Cell-specific expression, with the criterion being luciferase expression directed to GnRH neurons of the hypothalamus, was observed when 992 bp, but not 795 bp, of the hGnRH gene promoter were used. Tissue-specific expression was also observed when a deletion construct containing the region from −992 to −763 was fused to a minimal 48-bp promoter fragment fused to LUC. These data indicate that the region between −992 and −795 contains elements both essential and sufficient for targeting gene expression to GnRH neurons. This promoter region was found to contain two DNA-binding sites for the POU class of transcription factors, each of which specifically interacted with the POU homeodomain proteins Brn-2 and Oct-1. Functional studies demonstrated that Brn-2 increased promoter activity of the human and mouse GnRH genes.
A new robotic uterine positioner for laparoscopic hysterectomy with passive safety mechanisms: Design and experiments (2015)

In this paper, we present a new robotic uterine positioner for total laparoscopic hysterectomy. The robot is designed to actively position the patient's uterus during surgery, a lengthy and tedious task that is traditionally performed by a human assistant. Safety is simply the most important concern when developing robots for surgical purposes; we address this concern in the design of our robot from a mechanical perspective. To this end, we develop a 3-DOF robotic uterine positioner with an in-body remote center of motion (RCM); this key feature allows to prevent injuries to the patient when large motions occur at the cervix. A linearly-actuated arc-guided RCM mechanism is introduced to guarantee the rigidity and stability of the robot; The system's design allows to manipulate the uterus in a decoupled manner, thus control complexity can be reduced. Passive safety mechanisms are also implemented in all DOF of the robot in order to limit the interaction forces with the patient. Experiments, including an ex-vivo test conducted with cadaver, are conducted to verify the robot's performance.
Marxism, Wars and Revolutions: Essays from Four Decades (1988)

Isaac Deutscher is widely recognized as one of the foremost political biographers of the twentieth century, and his full-scale studies of Trotsky and Stalin, translated into many world languages, have played a major role in elucidating the character and fate of the Russian Revolution. This collection of essays, hitherto unpublished or out of print, provides a clear idea of the range and force of Deutscher s literary activity over a period of more than thirty years. It also demonstrates his essential consistency of purpose: from his sharp denunciation of the first Moscow Trial in 1936, through his resistance to the Cold War tides of the fifties, to his sober analysis of the Chinese Cultural Revolution in 1966. His fidelity to the Marxist method and firm grasp of socialist history allowed him to penetrate to the core of events without ever falling into the blind apologetics or feverish disavowals that blighted so many left-wing intellectuals of his generation. Deutscher s own origins in the Polish communist movement are here reflected in his famous interview on the tragedy of the Polish CP, while his major essay on bureaucracy is one of the few sustained attempts to grapple with this key theoretical and practical problem of the socialist movement. This volume is designed both as a lasting collection of some of Deutscher s best-known and most powerful texts, and as an introduction for readers approaching his work for the first time. A specially written preface by Perry Anderson assesses this selection in relation to Deutscher s overall achievement, and Tamara Deutscher s introduction passes on to the reader the often fascinating personal background to certain of the essays.
Optical phonons of aluminum nitride (1984)

Oriented polycrystalline films of AlN on Si(111) substrates and amorphous AlN films on sapphire substrates have been prepared by sputter deposition of aluminum in a nitrogen plasma. Phonons at 303, 426, 514, 614, 663, and 831 cm−1 (±3%) have been observed in the Raman spectra of the crystalline films. The 303-cm−1 phonon shifts to 288 cm−1 and the 663-cm−1 phonon to 650 cm−1 in the amorphous sample. By means of infrared absorption measurements with the electric field perpendicular to the c axis we have tentatively identified E1(LO) and E1(TO) modes near 800 and 610 cm−1, respectively. A tentative assignment of the other modes is made from partial data from orientation dependent scattering and results for other wurtzite structure compounds. A comparison of the AlN phonon frequencies with those of other known wurtzite structure compounds shows that Martin’s scaling equation is satisfied.
Reducing Connection Memory Requirements of MPI for InfiniBand Clusters: A Message Coalescing Approach (2007)

Clusters in the area of high-performance computing have been growing in size at a considerable rate. In these clusters, the dominate programming model is the Message Passing Interface (MPI), so the MPI library has a key role in resource usage and performance. To obtain maximal performance, many clusters deploy a high-speed interconnect between compute nodes. One such interconnect, InfiniBand, has been gaining in popularity due to its various features including Remote Data Memory Access (RDMA), and high-performance. As a result, it is being deployed in a significant number of clusters and has been chosen as the standard interconnect for capacity clusters within the DOE Tri-Labs. As these clusters grow in size, care must be taken to ensure the resource usage does not increase too significantly with scale. In particular, the MPI library resource usage should not grow at a rate which will exhaust the node memory or starve user applications. In this paper we present our findings of current memory usage when all connections are created and design a message coalescing method to decrease memory usage significantly. Our models show that the default configuration of MVAPICH can grow to 1GB per process for 8K processes, while our enhancements reduce usage by an order of magnitude to around 120 MB per process while maintaining near-equal performance. We have validated our design on a 575-node cluster and shown no performance degradation for a variety of applications. We also increase the message rate attainable by over 150%.