gebhart/patrepeval huggingface dataset:
Short antimicrobial peptides as cosmetic ingredients to deter dermatological pathogens (2015)

Antimicrobial peptides (AMPs) are components of the innate immune system in many species of animals. Their diverse spectrum of activity against microbial pathogens, both as innate defense molecules and immunomodulators, makes them attractive candidates for the development of a new generation of antibiotics. Although the potential immunogenicity of AMPs means they are not suitable for injection and their susceptibility to digestive peptidases is likely to reduce their oral efficacy, they are ideal for topical formulations such as lotions, creams, shampoos, and wound dressings and could therefore be valuable products for the cosmetic industry. In this context, short AMPs (<20 amino acids) lacking disulfide bonds combine optimal antimicrobial activity with inexpensive chemical synthesis and are therefore more compatible with large-scale production and the modifications required to ensure stability, low toxicity, and microbial specificity. Proof-of-concept for the application of AMPs as novel anti-infectives has already been provided in clinical trials. This perspective considers the anti-infective properties of short AMPs lacking disulfide bonds, which are active against dermatologically important microflora. We consider the challenges that need to be addressed to facilitate the prophylactic application of AMPs in personal care products.
miRNAMap: genomic maps of microRNA genes and their target genes in mammalian genomes (2005)

Recent work has demonstrated that microRNAs (miRNAs) are involved in critical biological processes by suppressing the translation of coding genes. This work develops an integrated database, miRNAMap, to store the known miRNA genes, the putative miRNA genes, the known miRNA targets and the putative miRNA targets. The known miRNA genes in four mammalian genomes such as human, mouse, rat and dog are obtained from miRBase, and experimentally validated miRNA targets are identified in a survey of the literature. Putative miRNA precursors were identified by RNAz, which is a non-coding RNA prediction tool based on comparative sequence analysis. The mature miRNA of the putative miRNA genes is accurately determined using a machine learning approach, mmiRNA. Then, miRanda was applied to predict the miRNA targets within the conserved regions in 3′-UTR of the genes in the four mammalian genomes. The miRNAMap also provides the expression profiles of the known miRNAs, cross-species comparisons, gene annotations and cross-links to other biological databases. Both textual and graphical web interface are provided to facilitate the retrieval of data from the miRNAMap. The database is freely available at .
C-Reactive Protein and the Future Risk of Thromboembolic Stroke in Healthy Men (2003)

Background— Evidence suggests that C-reactive protein (CRP) is related to thromboembolic (TE) stroke. Whether associations are altered in the presence of other risk factors is unclear. The purpose of this study was to additionally assess the relation between CRP and TE stroke. Methods and Results— On the basis of 20 years of follow-up after CRP measurement, 259 cases of TE stroke were identified and compared with 1348 controls. Subjects were aged 48 to 70 years when CRP was measured. Levels of CRP were positively associated with TE stroke throughout the 20 years of follow-up. Although associations were modest within 5 years of CRP measurement, the odds of stroke in the top versus bottom CRP quartile increased over time to a 3.8-fold excess by 10 to 15 years into follow-up ( P <0.001). For men without hypertension or diabetes, the overall corresponding odds were 1.6 to 1.7 ( P <0.05). In men ≤55 years of age, the odds increased to a 3-fold excess ( P =0.006), and in nonsmokers, there was a 5.8-fold excess ( P <0.001). Associations in past and current smokers, in men >55 years of age, and in those with hypertension or diabetes were not significant. Conclusions— Findings suggest that elevated CRP in middle adulthood and in men with healthier risk factor profiles may be important as a risk factor for TE stroke. Use of CRP levels as a clinical screen to identify an increased risk of cardiovascular disease in otherwise healthy men warrants consideration.
Tumor-Specific Anti-Nucleosome Antibody Improves Therapeutic Efficacy of Doxorubicin-Loaded Long-Circulating Liposomes against Primary and Metastatic Tumor in Mice (2008)

The efficacy of drug delivery systems can be significantly enhanced by making them target-specific via the attachment of various ligands to their surface. We attempted to enhance tumor accumulation and therapeutic effect of doxorubicin-loaded long-circulating liposomes (Doxil, ALZA Corp.) by coupling to their surface the anticancer monoclonal antibody 2C5 (mAb 2C5) with nuclesome (NS)-restricted activity, that can recognize the surface of various tumor but not normal cells via the surface-bound nucleosomes released from the apoptotically dying neighboring tumor cells and specifically targets pharmaceutical carriers to tumor cells in vitro and in vivo. Antibody coupling to PEGylated doxorubicin-liposomes was performed by the "post-insertion" technique. The pharmacokinetics of plain and immuno-targeted Doxil-mimicking liposomes, as well as their accumulation in primary Lewis lung carcinoma (LLC) tumors in mice was followed by real-time gamma-scintigraphy upon liposomal membrane labeling with (111)In. Therapeutic action of various liposomal formulations was followed by registering primary tumor growth, determining tumor weigh upon mice sacrifice, and by counting the number of metastases in the liver and lungs. 2C5 antibody-targeted liposomes demonstrate significantly enhanced accumulation in LLC tumors. Targeted doxorubicin-loaded PEG-liposomes were significantly more effective in inhibiting tumor growth and metastatic process in the LLC tumor models in mice. Our results clearly show the remarkable capability of 2C5-targeted Doxil to specifically deliver its cargo into various tumor manifestations (solid and metastatic) significantly increasing the efficacy of therapy.
High-Gain Planar Antenna Arrays for Mobile Satellite Communications [Antenna Applications Corner] (2012)

Two large and low-profile panel antenna arrays, used as receiving and transmitting antennas for mobile satellite communications, are described. The receiving and transmitting arrays have overall dimensions of 120 cm × 20.7 cm × 1.3cm and 107.5 cm × 20.4 cm × 1.7 cm, respectively. They exhibit high gains and adequate efficiencies, due to integrated array designs. For the receiving panel array, a method using a number of high-efficiency subarrays, combined with a novel active integrated global feed network, is proposed. For the transmitting panel array, a number of high-efficiency subarrays, together with a novel compact waveguide feed network, is employed. Based on the above techniques, two large panel antenna arrays were successfully developed. We present the detailed designs of the subarrays, the passive and active feed networks, and the vertical transitions. Simulated and experimental results showed that the designed receiving and transmitting panel arrays achieved measured gains and efficiencies of 34.1 dBi and 48.2%, and 33.5 dBi and 36.3%, respectively, in each band. This indicated that the proposed antenna panels are good candidates for future satellite communications applications.
Distinct Arachidonate-releasing Functions of Mammalian Secreted Phospholipase A2s in Human Embryonic Kidney 293 and Rat Mastocytoma RBL-2H3 Cells through Heparan Sulfate Shuttling and External Plasma Membrane Mechanisms (2001)

We analyzed the ability of a diverse set of mammalian secreted phospholipase A(2) (sPLA(2)) to release arachidonate for lipid mediator generation in two transfected cell lines. In human embryonic kidney 293 cells, the heparin-binding enzymes sPLA(2)-IIA, -IID, and -V promote stimulus-dependent arachidonic acid release and prostaglandin E(2) production in a manner dependent on the heparan sulfate proteoglycan glypican. In contrast, sPLA(2)-IB, -IIC, and -IIE, which bind weakly or not at all to heparanoids, fail to elicit arachidonate release, and addition of a heparin binding site to sPLA(2)-IIC allows it to release arachidonate. Heparin nonbinding sPLA(2)-X liberates arachidonic acid most likely from the phosphatidylcholine-rich outer plasma membrane in a glypican-independent manner. In rat mastocytoma RBL-2H3 cells that lack glypican, sPLA(2)-V and -X, which are unique among sPLA(2)s in being able to hydrolyze phosphatidylcholine-rich membranes, act most likely on the extracellular face of the plasma membrane to markedly augment IgE-dependent immediate production of leukotriene C(4) and platelet-activating factor. sPLA(2)-IB, -IIA, -IIC, -IID, and -IIE exert minimal effects in RBL-2H3 cells. These results are also supported by studies with sPLA(2) mutants and immunocytostaining and reveal that sPLA(2)-dependent lipid mediator generation occur by distinct (heparanoid-dependent and -independent) mechanisms in HEK293 and RBL-2H3 cells.
Temperature-modulated fluorescence tomography in a turbid media (2012)

High scattering in biological tissues makes fluorescence tomography inverse problem very challenging in thick medium. We describe an approach termed "temperature-modulated fluorescence tomography" that can acquire fluorescence images at focused ultrasound resolution. By utilizing recently emerged temperature sensitive fluorescence contrast agents, this technique provides fluorescence images with high resolution prior to any reconstruction process. We demonstrate that this technique is well suited to resolve small fluorescence targets located several centimeters deep in tissue.
Novel Proton Acceptor Immonium-Type Coupling Reagents:  Application in Solution and Solid-Phase Peptide Synthesis (2007)

A novel proton acceptor coupling reagent shows superiority to those described previously. The oxygen in the carbocation moiety confers more solubility to the reagent. Furthermore, it enhances coupling yields and decreases racemization, allowing the use of 1 equiv of base.
Cell Surface Receptor-mediated Internalization of Interferon: Its Relation to the Antiviral Activity of Interferon (1983)

The binding of [3H]leucine-labelled pure human interferon alpha from Namalwa cells to human FL and Daudi cells was studied, and evidence obtained to indicate receptor-mediated internalization of interferon. Cell surface-bound and internalized interferons were quantified separately as trypsin-released and unreleased radioactivities, respectively. At 37 degrees C, surface-bound interferon reached a maximum after 1 h and then decreased, while internalized interferon reached a maximum after 2 h. At 21 degrees C, in contrast, surface-bound interferon reached a maximum after 2 h and did not decrease thereafter; no internalization was observed. The same was true at 37 degrees C in the presence of NaF, indicating dependence of internalization on temperature and energy. In control cultures at 37 degrees C, internalized interferon, after reaching a maximum, decreased after prolonged incubation, and concomitantly acid-soluble radioactivity appeared in the culture medium. The decrease in internalized interferon and the emergence of degraded interferon were inhibited by the lysosomotropic agents, ammonium chloride and chloroquine. The fate of labelled interferon, bound to the cell surface of FL cells at 21 degrees C was studied at 37 degrees C, and the results indicated that trypsin-unreleased interferon was derived from the surface-bound interferon, and was secreted in part into the culture fluid in a degraded form upon prolonged incubation. The relation of internalization of interferon to its biological activity was studied in three ways. In FL cells, the antiviral activity was not induced when internalization of interferon was entirely blocked (at 21 degrees C or in the presence of NaF at 37 degrees C). In Daudi cells, both 2'-5'-oligoadenylate (2-5A) synthetase induction by interferon and internalization of interferon were inhibited completely by diethyldithiocarbamate (DDC), whereas in the case of FL cells, DDC inhibited neither 2-5A synthetase induction nor internalization of interferon. Raji cells, which have an interferon-specific binding site on the cell surface but are insensitive to interferon, were found not to internalize interferon, whereas other Burkitt's lymphoma cells, Daudi and Namalwa, which are sensitive to interferon, did internalize it. These findings suggest (but do not prove) that internalization is required for the establishment of interferon activity.
Coastal Engineering 1982 (1982)

These proceedings of the Eighteenth Coastal Engineering Conference held in Cape Town, Republic of South Africa, November 14-19, 1982 include the 167 papers presented at the conference. The proceedings are divided into 5 major subject areas. Part I, theoretical and observed wave characteristics, includes discussions on wave height distribution, waves in nearshore zones, tide predictions, wave energy conversion and wind effects. Part II, covers aspects of coastal sediment problems such as sediment transport, shore protection, beach profile changes, and beach erosion. Part III, coastal structures and related problems, covers construction, monitoring and performance of different coastal and offshore structures. Coastal, estuarine, and environmental problems are addressed in Part IV, including design of coastal water intakes, salinity intrusion, ocean outfalls, and environmental effects of construction. The final section covers ship motion response.
Solid Dispersions of Carvedilol with Porous Silica (2011)

Solid dispersion particles of carvedilol (CAR) were prepared with porous silica (Sylysia 350) by the solvent evaporation method in a vacuum evaporator to ensure an effective pore-filling procedure. Two sets were prepared, each with various amounts of CAR in solid dispersions, and with the pore-filling process differing each time. Set A was prepared by a one-step filling method and set B by a multiple-step pore-filling method of CAR into porous silica. The solid dispersions were then characterized using thermal analysis, X-ray diffraction, and nitrogen adsorption experiments. The results showed that the drug release can be significantly improved compared with the dissolution of the drug in its pure crystalline or amorphous state. Drug release from solid dispersion was faster when the drug content in the solid dispersion was low, which enabled the drug to be finely dispersed along the hydrophilic carrier's surface. The results also showed that a multiple-step pore-filling procedure is more effective for drug loading as indicated by the absence of a crystalline drug state, greatly reduced porosity, and improved wettability and physical stability of the amorphous CAR.
Real-Time Texture-less Object Recognition on Mobile Devices (2018)

This paper presents a technique for real-time texture-less object recognition and tracking on mobile devices. Our proposed algorithm is an even lighter-weight version of the recent state-of-the-art binary-based texture-less object detector BIND (Binary Integrated Net Descriptor), primarily customized for mobile device applications. This modification, termed BIND-Lite, employs various techniques to overcome the low-computational power of current mobile devices, while mostly retaining the texture-less object detection robustness of the original BIND. On current generation mobile devices, BIND-Lite was able to achieve runtime rates of up to 30 frames per second. To evaluate our algorithm, we have also designed a mobile augmented reality application coined IMPRINT, which renders logos/images onto detected objects to showcase BIND-Lite in a real-time mobile augmented reality setting.
Hydride films display mirror-window changes (1996)

RETURN TO ISSUEPREVNewsNEXTHydride films display mirror-window changesMICHAEL FREEMANTLECite this: Chem. Eng. News 1996, 74, 13, 9Publication Date (Print):March 25, 1996Publication History Published online12 November 2010Published inissue 25 March 1996https://pubs.acs.org/doi/10.1021/cen-v074n013.p009https://doi.org/10.1021/cen-v074n013.p009newsACS PublicationsCopyright © 1996 American Chemical SocietyArticle Views6Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Anions,Hydrogen,Thin films Get e-Alerts
I (1934)

Notes on the Determinateness of the Utility Function: I Get access E. H. Phelps Brown E. H. Phelps Brown Oxford Search for other works by this author on: Oxford Academic Google Scholar The Review of Economic Studies, Volume 2, Issue 1, October 1934, Pages 66–69, https://doi.org/10.2307/2967552 Published: 01 October 1934
Evidence for altered positional specificity of LCAT in vivo (2004)

The percentage of saturated cholesteryl esters (CEs) synthesized by human LCAT is several times higher than expected from the sn-2 acyl composition of plasma phosphatidylcholine (PC), whereas the synthesis of 20:4 CE and 22:6 CE is much lower than expected. To explain these discrepancies, we proposed that LCAT transfers some saturated fatty acids from the sn-1 position of PC species that contain 20:4 or 22:6 at sn-2. The present studies provide in vivo evidence for this hypothesis. We determined the composition and synthesis of CE species in plasma of volunteers before and after a 6 week dietary supplementation with docosahexaenoic acid (22:6; DHA). In addition to an increase in the DHA content of all plasma lipids, there was a significant (+12%; P <0.005) increase of 16:0 CE, although there was no increase in 16:0 at sn-2 of PC. The increase of DHA in CE was much lower than its increase at sn-2 of PC. Ex vivo synthesis of CE species in plasma showed a significant (+24%; P <0.005) increase in the synthesis of 16:0 CE after DHA supplementation, which correlated positively with the increase of 22:6, but not of 16:0, at sn-2 of PC. These results show that the positional specificity of human LCAT is altered when the concentration of 16:0-22:6 PC is increased by DHA supplementation.
Frequent and Focal <i>FGFR1</i> Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer (2010)

Lung cancer remains one of the leading causes of cancer-related death in developed countries. Although lung adenocarcinomas with EGFR mutations or EML4-ALK fusions respond to treatment by epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) inhibition, respectively, squamous cell lung cancer currently lacks therapeutically exploitable genetic alterations. We conducted a systematic search in a set of 232 lung cancer specimens for genetic alterations that were therapeutically amenable and then performed high-resolution gene copy number analyses. We identified frequent and focal fibroblast growth factor receptor 1 (FGFR1) amplification in squamous cell lung cancer (n = 155), but not in other lung cancer subtypes, and, by fluorescence in situ hybridization, confirmed the presence of FGFR1 amplifications in an independent cohort of squamous cell lung cancer samples (22% of cases). Using cell-based screening with the FGFR inhibitor PD173074 in a large (n = 83) panel of lung cancer cell lines, we demonstrated that this compound inhibited growth and induced apoptosis specifically in those lung cancer cells carrying amplified FGFR1. We validated the FGFR1 dependence of FGFR1-amplified cell lines by FGFR1 knockdown and by ectopic expression of an FGFR1-resistant allele (FGFR1(V561M)), which rescued FGFR1-amplified cells from PD173074-mediated cytotoxicity. Finally, we showed that inhibition of FGFR1 with a small molecule led to significant tumor shrinkage in vivo. Thus, focal FGFR1 amplification is common in squamous cell lung cancer and associated with tumor growth and survival, suggesting that FGFR inhibitors may be a viable therapeutic option in this cohort of patients.
Modeling of Mach-Zehnder and electroabsorption modulator pulse generators and extraction of the chirp factor (2015)

The chirp factor of optical modulators is an important parameter that relates how the induced phase varies with the instantaneous power of a generated optical pulse, from which the dynamic chirp can be obtained. The two most common modulators are Lithium Niobate Mach-Zehnder and electroabsorption modulators. This paper describes simple models of the modulator response and uses a linear pulse characterization method to measure pulse intensity and phase. The experimental chirp measurements are used in conjunction with the models to determine modulator chirp factor.
New Resistance in<i>Staphylococcus aureus</i> (1999)

“Tu quoque, fili?” means “You, my son, as well?” This was Julius Caesar's outcry when, surrounded by conspirators ready to stab him to death, he discovered among them Brutus, his adopted son. Caesar's outcry was one of surprise, but also one of recognition that Brutus's betrayal could have been predicted.Vancomycin, now, as well? This was the semisurprised reaction of the microbiologic and medical community in 1997 — more than 50 years after the introduction of penicillin in the war against bacteria — to a well-documented report from Japan that vancomycin resistance was emerging as the latest setback . . .
Elevated levels of ERK2 in human breast carcinoma MCF‐7 cells transfected with protein kinase Cα (1996)

We investigated the effect of elevated levels of protein kinase C alpha (PKC alpha) on cell proliferation in human breast carcinoma cells (MCF-7). MCF-7 cells transfected with either the pSV2M(2)6 vector without the insert (MCF-7/Vector) or containing a full length cDNA encoding PKC alpha (MCF-7/PKC alpha) were compared. MCF-7/PKC alpha cells were found to have an increased proliferative rate with a doubling time of 15 h as compared to 42 h for MCF-7/Vector cells. Flow cytometry illustrated a greater percentage of MCF-7/PKC alpha cells in the S phase of the cell cycle. Western and Northern blot analyses demonstrated an increase in extracellular regulated protein kinase 2 (ERK2) gene expression in MCF-7/PKC alpha cells but no alteration of this gene expression in MCF-7/Vector cells. These results suggested that the elevated level of ERK2 which is also known as mitogen activated protein kinase is probably involved in the increase in MCF-7/PKC alpha cell proliferation.
L'impact de la diminution des durées d'hospitalisation pour menace d'accouchement prématuré : Étude à la Maternité Régionale de Nancy (2012)

par le jury de soutenance et mis disposition de l'ensemble de la communaut universitaire largie.