gebhart/patrepeval huggingface dataset:
Mean-Variance and Scenario-Based Approaches to Portfolio Selection (1999)

In this cautionary tale, the sorcerer's apprentice uses his mentor's magic before he knows how to control it. Matters quickly get out of hand. The author argues that the scenario-based expected utility maximization approach to portfolio optimization presents similar opportunities for misadventure. He shows how to avoid the danger, Alas, as with all sorcery, when the illusion is stripped away one sees that there is less there than initially supposed. The conventional mean-variance approach gives comparable answers with less bother and peril.
Single-electron effects in heavily doped polycrystalline silicon nanowires (1998)

We have observed single-electron charging effects in heavily doped polycrystalline silicon nanowires at 4.2 K. Wires of approximately 20 nm by 30 nm active cross section were defined by electron-beam lithography and thermal oxidation in standard polycrystalline silicon material. We have measured a Coulomb staircase and periodic current oscillations with gate bias, attributed to localized carrier confinement resulting from a statistical variation in the intergrain tunnel barriers. A sharp change in the current oscillation period is seen and we speculate that it is due to electrostatic screening of the gate bias by grain boundary defect states.
Novel VCSEL driving technique with virtual back termination for high-speed optical interconnection (2012)

In this work, we develop a simple and high-speed VCSEL driving technique with "virtual back termination" for optical interconnect applications. For achieving compact and high-speed optical interconnects, an optical module with the flipchip bonding structure is effective. To realize flip-chip mounting, the development of the VCSEL driving technique, which can perform impedance matching with the transmission line, is a critical issue. Back termination has to be implemented to reduce signal reflection via the transmission line. Additionally, back termination must have a simple dc coupling. Introducing a virtual GND to the circuit ensures that these requirements are met. The virtual GND is made by a dummy load connected to a complementary output and dc-coupled 50-Ω resisters between output and complementary output. The dummy load has characteristics similar to the load VCSEL. As a result of the virtual GND, the resisters act as the back termination. When we drove the VCSEL with this technique, clear eye opening without the reflectance effects was obtained up to 28-Gb/s despite using a 10-cm transmission These results show that our driving technique is suitable for high-speed optical interconnect applications.
VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION IN TRANSPLANTED HUMAN HEARTS1,2 (1995)

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen thought to play an important role in coronary collateral vessel formation. We used immunocytochemistry to determine VEGF expression in biopsies (n = 283) of transplanted human hearts (n = 109) with and without microvascular fibrin. Measures of vascular fibrin, alpha 2 plasmin-inhibitor (a2Pl), macrophages, neutrophils, and serum cardiac troponin T titers were used to evaluate myocardial damage. Antibody to T lymphocytes was used to evaluate cellular rejection, and HLA-DR, ICAM-1, and PAL-E antibodies were used to assess endothelial cell activation and phenotypic changes in the microcirculation. No VEGF immunoreactivity was detected in control donor hearts without fibrin, but the proportion of biopsies demonstrating VEGF immunoreactivity increased significantly in allografts with increasing fibrin and a2PI reactivity (P = 0.0001). VEGF immunoreactivity was confined to areas of fibrin deposition and was associated with infiltrates of macrophages and neutrophils (P < 0.0001), but not with T cells (P = 0.10). Biopsies with fibrin/VEGF reactivity were associated with increased capillary endothelial cell HLA-DR, ICAM-1, and PAL-E reactivity. In a subset of patients, serum cardiac troponin-T values were greater in patients with VEGF-positive (n = 21) than VEGF-negative (n = 19) biopsies (P = 0.05). Nested RT-PCR demonstrated that biopsies with and without fibrin/VEGF immunoreactivities expressed VEGF121, VEGF165, and VEGF189 variants, with VEGF165 being the dominate variant. These results indicate that endogenous VEGF is expressed locally following vascular thrombosis and myocardial cell damage, and that VEGF expression may be related to endothelial cell activation and phenotypic changes found in the microcirculation of cardiac allografts.
Foreword (1994)

Foreword Get access D. G. Julian D. G. Julian London, U. K. Search for other works by this author on: Oxford Academic PubMed Google Scholar European Heart Journal, Volume 15, Issue suppl_B, May 1994, Page 1, https://doi.org/10.1093/eurheartj/15.suppl_B.1 Published: 01 May 1994
An Electronic Method for Measuring the Fit of Removable Partial Denture Frameworks to Dental Casts (2009)

It is well established that the Removable Partial Denture (RPD) is an effective treatment prosthesis. The objectives of a successful RPD are: to preserve the health of remaining oral structure, restore function and restore esthetics. To achieve these objectives, an RPD framework must fit accurately to the supporting structures. This paper presents a method for measuring the gaps or spaces present between the RPD framework and supporting structures which will enable the dentist and the dental technician to evaluate the accuracy of fitting of the prosthesis before it is delivered to the patient. The method used in this research is based on the principle of electric capacitance and uses a specially designed prototype measurement system.
Turn Signal Detection During Nighttime by CNN Detector and Perceptual Hashing Tracking (2017)

Detecting vehicle turn signals at night is critical for both assistant driving systems and autonomous driving systems. In this paper, we propose a novel method that consists of detection and tracking modules to achieve a high level of robustness. For nighttime vehicle detection, a Nakagami-image-based method is used to locate the regions containing vehicle lights. At the same time, a set of vehicle object proposals is generated using a region proposal network based on convolutional neural network (CNN) feature maps. Then, the light regions and proposals are combined to generate the regions of interest (ROIs) for the further detection. Vehicle candidates are extracted from the ROIs using a softmax classifier with CNN-based features. For the tracking module, we propose a perceptional hashing algorithm to track these vehicle candidates. During the tracking, turn signals are detected by analyzing the continuous intensity variation of the vehicle box sequences. Experimental results for typical sequences show that the proposed method can robustly detect and track a vehicle in front with over 95% accuracy and recognize the turning signals in night scenes with a detection rate of over 90%. The vehicle detection method improves the miss rate of state-of-the-art systems by more than 20%. In addition, the proposed vehicle tracking method outperforms other state-of-the-art systems.
Structural biology of the alternative pathway convertase (2001)

Complement convertases are bimolecular complexes expressing protease activity only against C3 and C5. Their action is necessary for production of the biological activities of the complement system. Formation of these complexes proceeds through sequential protein-protein interactions and proteolytic cleavages of high specificity. Recent structural, mutational and functional data on factors D and B have significantly enhanced our understanding of the assembly, action, and regulation of the alternative pathway convertase. These processes were shown to depend critically on conformational changes, only some of which are reversible. The need for such changes is dictated by the zymogen-like configurations of the active centers of these unique serine proteases. The structural determinants of some of these changes have been defined from structural and mutational analyses of the two enzymes. Transition of factor D from the zymogen-like to the catalytically active conformation is completely reversible, while the active conformation of the catalytic center of the Bb fragment of factor B is irreversibly attenuated to a great extent on dissociation of the convertase complex. Both mechanisms contribute to the regulation of the proteolytic activity of these enzymes. Additional studies are necessary for a complete description of the elegant mechanisms mediating these processes.
Probabilistically bounded staleness for practical partial quorums (2012)

Data store replication results in a fundamental trade-off between operation latency and data consistency. In this paper, we examine this trade-off in the context of quorum-replicated data stores. Under partial, or non-strict quorum replication, a data store waits for responses from a subset of replicas before answering a query, without guaranteeing that read and write replica sets intersect. As deployed in practice, these configurations provide only basic eventual consistency guarantees, with no limit to the recency of data returned. However, anecdotally, partial quorums are often "good enough" for practitioners given their latency benefits. In this work, we explain why partial quorums are regularly acceptable in practice, analyzing both the staleness of data they return and the latency benefits they offer. We introduce Probabilistically Bounded Staleness (PBS) consistency, which provides expected bounds on staleness with respect to both versions and wall clock time. We derive a closed-form solution for versioned staleness as well as model real-time staleness for representative Dynamo-style systems under internet-scale production workloads. Using PBS, we measure the latency-consistency trade-off for partial quorum systems. We quantitatively demonstrate how eventually consistent systems frequently return consistent data within tens of milliseconds while offering significant latency benefits.
Methods for determining the accuracy of radiostereometric analysis (RSA) (2000)

The problem of determining the noise level in any measuring system remains urgent. Radiostereometric analysis (RSA) is a radiographic system of unique accuracy which has applications in areas where minute motions or no motion at all occurs. Examples are micromotion between endoprostheses and bone and in fracture healing. We have determined the accuracy of the RSA system as applied to a clinical series of spinal fusions, where the conditions for RSA were not optimal. Using the usual test-retest methodology on a phantom, we showed that its accuracy can be grossly overestimated in the individual case. We found considerable variations in the accuracy in the individual case, depending on the rigid-body configuration. The overall accuracy, expressed as 3-D "vectors" for rotation and translation, respectively, correlated with the condition number, a method for characterizing the marker configuration. Indeed, the condition number explained as much as 92% of the variation in overall rotation. This condition number, however, cannot be used to analyze the accuracy of one degree of freedom of rotation alone. Mathematical simulation of the accuracy in the individual case of the individual dimension, using in-house software, showed that the accuracy (95% confidence) varied between 0.4 and 4.6 degrees of rotation about the transverse axis, corresponding to a clinical stress series of extension and flexion.
A 110-MHz 84-dB CMOS programmable gain amplifier with integrated RSSI function (2005)

This paper describes a CMOS programmable gain amplifier (PGA) that maintains a 3-dB bandwidth greater than 110 MHz and can provide an 84-dB gain control range with 1-dB step resolution. The PGA can also be operated in a low-power mode with 3-dB bandwidth greater than 71 MHz. Integrated with this PGA is a CMOS successive logarithmic detecting amplifier with a /spl plusmn/0.7-dB logarithmic accuracy over an 80-dB dynamic range. It achieves -83-dBm sensitivity and consumes 13 mA from a single 3-V supply in the normal power mode. The chip area, including pads, occupies 1.5/spl times/1.5 mm/sup 2/.
Diversity of Antibody-Mediated Immunity at the Mucosal Barrier (1999)

Although over 90% of all human infections begin at a mucosal site (respiratory, gastrointestinal, urogenital, or ocular), the total number of infections occurring in the population is relatively low. This is in part the result of the secretion of a complex array of local and systemically produced immunoglobulins (Igs). Since the time of Pasteur (37), when immunization by the oral route was first described, and the identification of a special mucosal immune system by Besredka (7), considerable progress in understanding secretory immunity in humans has been achieved. Mechanisms of induction, synthesis, translocation, and activity of secretory immunoglobulin A (S-IgA) antibodies are now well established, as extensively reviewed in a recent book (46). However, while it would be more effective to block infections at the mucosa by using specific mucosal vaccines, the only such vaccine commercialized for human use is the oral polio vaccine (53). This delay in commercialization is due to the necessity of optimizing safety and efficacy which are related to a number of factors such as the requirements for persistent antigens (Ags) which linger on mucosal surfaces, for highly effective mucosal adjuvants, and for live mucosal vaccine vectors with harmless colonizing properties. Present efforts have focused on the study of both mucosal adjuvants, mainly cholera toxin and its derivatives, and immunogens such as encapsulated molecules, DNA, and recombinant microorganisms. Alternatively, an understanding of additional aspects of antibody-mediated immunity in secretions may enable us to develop new methods of local protection against pathogens. We present here those immune mechanisms known to be used by the host to block infection at the mucosal surface and discuss their respective importance and limitations.
Comparison of laboratory tests used for identification of the lupus anticoagulant (1989)

A comparison of the sensitivities of the ten most commonly used tests for the identification of the lupus anticoagulant (LA) and the lupus cofactor phenomenon was undertaken on 18 patients. All investigations, except the cardiolipin-antibody ELISA assay, were carried out using patient's plasma alone followed by a 1:1 mix with control plasma. Dilution studies (1:3, 1:6, 1:9--patient:control) were also carried out. The kaolin clotting time (KCT) was the only test positive in all patients at all dilutions, while the dilute activated partial thromboplastin time with kaolin (Dil-APTT) registered 17 of 18 positive at all dilutions. Both the dilute Russell viper venom time (Dil-RVVT) and the tissue thromboplastin inhibition time (TTI) (1/500 thromboplastin) identified the LA in 17 of 18 patients on initial testing but were less sensitive in the dilution studies. The KCT is not a suitable test for routine laboratory use, as it requires an individual filtration step. Therefore a combination of either the Dil-APTT or Dil-RVVT together with the TTI (1/500 dilution thromboplastin) is recommended for routine LA screening, as all patients with LA in this study were identified using these easily automated tests. The lupus cofactor phenomenon was most frequently demonstrated using the Dil-APTT.
The use of DNA probes for taxonomic study of dictyostelium wild isolates. (1988)

The classification of 27 wild isolates assigned to Dictyostelium discoideum on the basis of morphological criteria was reexamined using probes specific for DNA sequences cloned from the type strain NC4. These probes included ones specific for ribosomal spacer DNA regions and for a ribosomal RNA coding sequence, as well as probes for two chromosomal gene families (actin and discoidin) and for the DIRS-1 transposable element. Four isolates (AC4, WS526, WS584 and ZA3A) which had previously been shown to have unusual mating characteristics were distinctly different from other isolates. We interpret these differences as indicating that the four atypical isolates represent species other than D. discoideum. Probes for the ribosomal spacer DNA either did not hybridize to the DNA of these four isolates or had decreased levels of hybridization to EcoRI restriction fragments of different lengths to that observed with the type strain. With the discoidin probe, all isolates had DNA fragments that hybridized but AC4, WS526, WS584 and ZA3A lacked a pair of fragments that were conserved in NC4 and other isolates. With the actin probe, AC4, WS526, WS584 and ZA3A lacked numerous fragments that the other isolates shared with NC4. The DIRS-1 probes showed strong hybridization with ZA3A and weak hybridization to the other three isolates; however, the major EcoRI fragment in WS526 and WS584 was smaller than that in NC4 while ZA3A and AC4 had fragments of similar size to that in NC4.(ABSTRACT TRUNCATED AT 250 WORDS)
MMC—A Recurrent Neural Network Which Can Be Used As Manipulable Body Model (1998)

A recurrent network is proposed which can be used as a manipulable body model to solve different kinematic tasks as the inverse kinematic problem, the direct kinematic problem or any mixed problem. The model may be used for planning a movement, or ,,thinking , by being uncoupled from the motor output, or it may be used for direct motor control. The network is based on a new type of neuronal network called MMC net which is similar to but shows some essential differences to the Hopfield tlpe network. These are (l) no symmetrical rveights are necessary in the MMC net. (2) Furthermore, no clipping functions are necessary which allows for real valued outputs. (3) No limited number of discrete attractors. but an infinite number of attractors ll'hich form a continuum are possible in the MMC network.
Organisational culture, leadership behaviour and job satisfaction in the Vietnam context (2020)

Purpose The purpose of this paper is to challenge the influence of organisational culture types on leadership behaviour and job satisfaction. The theory of culture was divided into four characteristics, namely, clan, hierarchy, adhocracy and market. Design/methodology/approach A purposive questionnaire was adapted to collect surveys from 294 working people in several sector organisations in Vietnam. The questionnaire included two main parts. The first part comprising demographic questions. The second part included three constituted scales to evaluate organisational culture types, leadership behaviour and job satisfaction. Correlation and linear regression analysis were adapted to use to challenge connections among variables. Findings Hierarchy culture negatively connected to relationship-oriented leadership behaviour. Adhocracy culture positively affected job satisfaction. Clan and market cultures insignificantly predicted leadership style and job satisfaction. Research limitations/implications The research is structured in 294 working people in various Vietnamese sector organisations. This small sample is unlikely to represent the popularity of the findings. Further research should collect samples in more organisations and industries in Vietnam to improve the efficiency of the results. The research findings may support leaders and superiors to choose a proper organisational culture that will reduce employee dissatisfaction. Originality/value The research is conducive to the studies on organisational culture, especially the association between leadership behaviour and job satisfaction in Vietnamese sector organisations
The<i>turnip</i>Mutant of Arabidopsis Reveals That<i>LEAFY COTYLEDON1</i>Expression Mediates the Effects of Auxin and Sugars to Promote Embryonic Cell Identity (2006)

The transition from embryonic to vegetative growth marks an important developmental stage in the plant life cycle. The turnip (tnp) mutant was identified in a screen for modifiers of POLARIS expression, a gene required for normal root growth. Mapping and molecular characterization of tnp shows that it represents a gain-of-function mutant of LEAFY COTYLEDON1 (LEC1), due to a promoter mutation. This results in the ectopic expression of LEC1, but not of other LEC genes, in vegetative tissues. The LEC class of genes are known regulators of embryogenesis, involved in the control of embryonic cell identity by currently unknown mechanisms. Activation of the LEC-dependent pathway in tnp leads to the loss of hypocotyl epidermal cell marker expression and loss of SCARECROW expression in the endodermis, the ectopic accumulation of starch and lipids, and the up-regulation of early and late embryonic genes. tnp also shows partial deetiolation during dark growth. Penetrance of the mutant phenotype is strongly enhanced in the presence of exogenous auxin and sugars, but not by gibberellin or abscisic acid, and is antagonized by cytokinin. We propose that the role of LEC1 in embryonic cell fate control requires auxin and sucrose to promote cell division and embryonic differentiation.
Polymeric iron chelates for nitric oxide removal from flue gas streams (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymeric iron chelates for nitric oxide removal from flue gas streamsStephen A. Bedell, Susan S. Tsai, and Robert R. GrinsteadCite this: Ind. Eng. Chem. Res. 1988, 27, 11, 2092–2095Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/ie00083a022https://doi.org/10.1021/ie00083a022research-articleACS PublicationsRequest reuse permissionsArticle Views100Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An improved yeast surface display platform for the screening of nanobody immune libraries (2019)

Fusions to the C-terminal end of the Aga2p mating adhesion of Saccharomyces cerevisiae have been used in many studies for the selection of affinity reagents by yeast display followed by flow cytometric analysis. Here we present an improved yeast display system for the screening of Nanobody immune libraries where we fused the Nanobody to the N-terminal end of Aga2p to avoid steric hindrance between the fused Nanobody and the antigen. Moreover, the display level of a cloned Nanobody on the surface of an individual yeast cell can be monitored through a covalent fluorophore that is attached in a single enzymatic step to an orthogonal acyl carrier protein (ACP). Additionally, the displayed Nanobody can be easily released from the yeast surface and immobilised on solid surfaces for rapid analysis. To prove the generic nature of this novel Nanobody discovery platform, we conveniently selected Nanobodies against three different antigens, including two membrane proteins.