gebhart/patrepeval huggingface dataset:
Controlled-root formulation for digital phase-locked loops (1995)

In a new formulation for digital phase-locked loops, loop-filter constants are determined from loop roots that can each be selectively placed in the s-plane on the basis of a new set of parameters, each with single and direct physical meaning in terms of loop noise band, width root-specific decay rate, or root-specific damping. Loops of first to fourth order are treated in the continuous-update approximation (B/sub L/T/spl rarr/0) and in a discrete-update formulation with arbitrary B/sub L/T. Deficiencies of the continuous-update approximation in large-B/sub L/T applications are avoided in the new discrete-update formulation. A new method for direct, transient-free acquisition with third- and fourth-order loops can improve the versatility and reliability of acquisition with such loops.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
In Vitro Activities of Terbinafine against Cutaneous Isolates of<i>Candida albicans</i>and Other Pathogenic Yeasts (1998)

Terbinafine is active in vitro against a wide range of pathogenic fungi, including dermatophytes, molds, dimorphic fungi, and some yeasts, but earlier studies indicated that the drug had little activity against Candida albicans. In contrast, clinical studies have shown topical and oral terbinafine to be active in cutaneous candidiasis and Candida nail infections. In order to define the anti-Candida activity of terbinafine, we tested the drug against 350 fresh clinical isolates and additional strains by using a broth dilution assay standardized according to the guidelines of the National Committee for Clinical Laboratory Standards (NCCLS) M27-A assay. Terbinafine was found to have an MIC of 1 microg/ml for reference C. albicans strains. For 259 clinical isolates, the MIC at which 50% of the isolates are inhibited (MIC50) of terbinafine was 1 microg/ml (fluconazole, 0.5 microg/ml), and the MIC90 was 4 microg/ml (fluconazole, 1 microg/ml). Terbinafine was highly active against Candida parapsilosis (MIC90, 0.125 microg/ml) and showed potentially interesting activity against isolates of Candida dubliniensis, Candida guilliermondii, Candida humicola, and Candida lusitaniae. It was not active against the Candida glabrata, Candida krusei, and Candida tropicalis isolates in this assay. Cryptococcus laurentii and Cryptococcus neoformans were highly susceptible to terbinafine, with MICs of 0.06 to 0.25 microg/ml. The NCCLS macrodilution assay provides reproducible in vitro data for terbinafine against Candida and other yeasts. The MICs for C. albicans and C. parapsilosis are compatible with the known clinical efficacy of terbinafine in cutaneous infections, while the clinical relevance of its activities against the other species has yet to be determined.
FERMENTATIVE PRODUCTION OF L-SERINE (1972)

A new species Corynebacterium glycinophilum nov. sp. was isolated from a putrefied banana, which is resistant to a high concentration of glycine and has a prominent ability of producing L-serine from glycine.Among various substances supplemented to the medium used, nicotinamide was found to be effective for L-serine production. The L-serine production was in parallel with the consumption of glycine in the medium. Ferrous ion was found to depress L-serine production and to increase the assimilation of glycine added.Glycine was utilized as a nitrogen source in the presence of glucose, but was not utilized as a carbon source in the absence of glucose. The addition of inorganic nitrogen increased L-serine production. Glycine was not formed from L- serine. L-Threonine was formed with L-serine from glycine, probably by serine transhydroxymethylase.
Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full‐length isoform of the liver‐specific transporter‐1 (rlst‐1) in rat liver (2000)

A novel organic anion transporting polypeptide (Oatp)4(1) was isolated from rat liver that is 35 amino acids longer than the reported rat liver specific organic anion transporter (rlst)-1 and exhibits a 64% amino acid sequence identity with the human OATP-C (LST-1/OATP2; gene symbol SLC21A6). When expressed in Xenopus laevis oocytes, Oatp4 (Slc21a10) mediated polyspecific uptake of a variety of organic anions including taurocholate (K(m) approximately 27 microM), bromosulfophthalein (K(m) approximately 1.1 microM) and steroid conjugates. Based on nuclease protection analysis Oatp4 appears to be the predominant transcript in rat liver indicating that rlst-1 plays a minor role in overall hepatic organic anion uptake.
Active Vision: Directing Visual Attention (2008)

Active vision is the research topic where the vision process is dynamic; i.e. movement of a camera is controlled purposively. The image processing is applied to a sequence of images where a mechanism decides which feature or object should be followed. Attentive vision is an element of active vision where the outcome of an attention selection mechanism differentiates between locations to be attended. When combined, a vision system can direct attention in two ways; top-down and bottom-up tracking. Top-down tracking consists in estimating the position and characteristics of an object of interest, given its position and characteristics in the previous frame. Therefore, particle filters and Kalman filters represent this top-down technique for tracking. The bottom-up approach consists simply in segmenting the object of interest in each frame or Region of Interest and match them over time. This top-down/bottom-up method can also be identified in detecting visual attention. Regard-ing the bottom-up approach, no prior knowledge for salience is used to direct attention selection. However, top-down mechanisms could be employed to direct attention to certain objects which
A microprocessor-controlled multichannel counter for a digital autocorrelator (radioastronomical application) (1983)

A multichannel general purpose counter, composed of 1024*32-bit counters, is presented. The circuit is based on a random access memory, and is microprocessor controlled. The microprocessor structure is also described. This circuit has been developed for a digital autocorrelator for radioastronomical observations.
Short Sequence in LI Region of Human Papillomaviruses Correlates with Clinical Pictures and Grouping by Cross‐hybridization (1992)

A consensus primer-mediated polymerase chain reaction devised to amplify a short sequence in L1 region (L1-PCR) efficiently detected genital human papillomaviruses (HPVs) in clinical materials. Nucleotide sequencing of the amplified fragment showed that L1-PCR is also applicable to hitherto unsequenced HPVs. By comparing the amplified 210 nucleotides HPVs were classified into six groups, which are consistent with clinical pictures and a grouping based on cross-hybridization under the stringent condition.
High-Temperature Joining of Ceramics and Sapphire by Laser-Based Process (2014)

Ceramics and sapphire are housing materials that are resistant to extreme stress and used in extreme environments today. The necessary high temperatures in conventional joining procedures are not suitable for encapsulating components owing to the functional requirements. Therefore new technologies are being developed in order to achieve local and time-limited heat input into the joining zone and thus to reach the necessary joining temperature. This following paper deals with high-temperature joining with laser beams using high-temperature glass filler material e.g. glass solder. Even if the working temperature is above 450 °C, the filler material is referred to glass solder in scientific terminology. Practice-related examples demonstrate the experimental investigations on control of the process control as well as on joint formation and the resulting properties.
Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL) (2009)

Clinical risk classification is inaccurate in predicting relapse in adult patients with acute lymphoblastic leukemia, sometimes resulting in patients receiving inappropriate chemotherapy or stem cell transplantation (SCT). We studied minimal residual disease (MRD) as a predictive factor for recurrence and as a decisional tool for postconsolidation maintenance (in MRD(neg)) or SCT (in MRD(pos)). MRD was tested at weeks 10, 16, and 22 using real-time quantitative polymerase chain reaction with 1 or more sensitive probes. Only patients with t(9;22) or t(4;11) were immediately eligible for allogeneic SCT. Of 280 registered patients (236 in remission), 34 underwent an early SCT, 60 suffered from relapse or severe toxicity, and 142 were evaluable for MRD at the end of consolidation. Of these, 58 were MRD(neg), 54 MRD(pos), and 30 were not assessable. Five-year overall survival/disease-free survival rates were 0.75/0.72 in the MRD(neg) group compared with 0.33/0.14 in MRD(pos) (P = .001), regardless of the clinical risk class. MRD was the most significant risk factor for relapse (hazard ratio, 5.22). MRD results at weeks 16 to 22 correlated strongly with the earlier time point (P = .001) using a level of 10(-4) or higher to define persistent disease. MRD analysis during early postremission therapy improves risk definitions and bolsters risk-oriented strategies. ClinicalTrials.gov identifier: NCT00358072.
Inactivation of Virus in Sewage (1971)

Inactivation of virus in sewage effluent was investigated using a rapid sampling reaction system. The effects of pH and varied reaction conditions are reported. Data presented strongly support the hypothesis that free chlorine is required for significant viral inactivation. The viricidal activity of chlorine at different pH levels correlates better with the persistence of free chlorine than with the theoretical percent HOCl present. It appears that the more significant role of pH in the inactivation of viruses is the control of chlorine wasting side reactions.
Hydrogen storage capacity of titanium met-cars (2006)

The adsorption of hydrogen molecules on the titanium metallocarbohedryne (met-car) cluster has been investigated by using the first-principles plane wave method. We have found that, while a single Ti atom at the corner can bind up to three hydrogen molecules, a single Ti atom on the surface of the cluster can bind only one hydrogen molecule. Accordingly, a Ti8C12 met-car can bind up to 16H2 molecules and hence can be considered as a high-capacity hydrogen storage medium. Strong interaction between two met-car clusters leading to the dimer formation can affect H2 storage capacity slightly. Increasing the storage capacity by directly inserting H 2 into the met-car or by functionalizing it with an Na atom have been explored. It is found that the insertion of neither an H2 molecule nor an Na atom could further promote the H2 storage capacity of a Ti8C12 cluster. We have also tested the stability of the H2-adsorbed Ti8C12 met-car with ab initio molecular dynamics calculations which have been carried out at room temperature.
Asymmetric Synthesis of (+)-Bicyclo[2.2.2]-octanol-2<sup>1</sup> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric Synthesis of (+)-Bicyclo[2.2.2]-octanol-21H. M. Walborsky and A. E. YoungCite this: J. Org. Chem. 1962, 27, 6, 2261Publication Date (Print):June 1, 1962Publication History Published online1 May 2002Published inissue 1 June 1962https://pubs.acs.org/doi/10.1021/jo01053a536https://doi.org/10.1021/jo01053a536research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On parallel random number generation for accelerating simulations of communication systems (2014)

Abstract. Powerful compute clusters and multi-core systems have become widely available in research and industry nowadays. This boost in utilizable computational power tempts people to run compute-intensive tasks on those clusters, either for speed or accuracy reasons. Especially Monte Carlo simulations with their inherent parallelism promise very high speedups. Nevertheless, the quality of Monte Carlo simulations strongly depends on the quality of the employed random numbers. In this work we present a comprehensive analysis of state-of-the-art pseudo random number generators like the MT19937 or the WELL generator used for parallel stream generation in different settings. These random number generators can be realized in hardware as well as in software and help to accelerate the analysis (or simulation) of communications systems. We show that it is possible to generate high-quality parallel random number streams with both generators, as long as some configuration constraints are met. We furthermore depict that distributed simulations with those generator types are viable even to very high degrees of parallelism.
Thermosonic gold wire bonding to palladium finishes on laminate substrates (2002)

As the laminate substrate industry moves from hot air solder level (HASL) finishes, alternate plating finishes are being proposed, such as immersion gold/electroless nickel, electroless palladium and electroless silver. This paper presents results of an evaluation of the thermosonic gold ball wire bondability of electroless palladium. Two palladium thicknesses, with and without a nickel underlayer, from two vendors were evaluated. In each case, a thin gold passivation layer was deposited by immersion plating over the palladium. The initial evaluation criteria included bondability (number of missed bonds and flame-off errors), wire pull strength, standard deviation, bond failure mode and visual inspection. The bonding window was determined by independently varying force (4 levels), power (4 levels) and time (2 levels). The stage temperature was maintained at 150/spl deg/C, compatible with BT laminate material. The effects of different preconditioning environments such as a solder reflow cycle, high temperature storage (125/spl deg/C) and humidity storage (85% RH/85/spl deg/C) on initial bondability were also considered. Rutherford backscattering and Auger analysis were used to examine the surface finishes. The stability of the bonds was investigated by high temperature storage (125/spl deg/C) with periodic electrical resistance and pull strength testing.
Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus (2017)

<b>Purpose:</b> Pancreatic cancer is a severe indication with short expected survival despite surgery and/or combination chemotherapeutics. Checkpoint blockade antibodies are approved for several cancer indications, but pancreatic cancer has remained refractory. However, there are clinical data suggesting that stimulation of the CD40 pathway may be of interest for these patients. Oncolytic viruses armed with immunostimulatory genes represent an interesting approach. Herein, we present LOAd703, a designed adenovirus armed with trimerized <i>CD40L</i> and <i>4-1BBL</i> that activates the CD40 and 4-1BB pathways, respectively. As many cells in the tumor stroma, including stellate cells and the infiltrating immune cells, express CD40 and some 4-1BB, we hypothesize that LOAd703 activates immunity and simultaneously modulates the biology of the tumor stroma.<b>Experimental Design:</b> Tumor, stellate, endothelial, and immune cells were infected by LOAd703 and investigated by flow cytometry, proteomics, and functional analyses.<b>Results:</b> LOAd703-infected pancreatic cell lines were killed by oncolysis, and the virus was more effective than standard-of-care gemcitabine. In <i>in vivo</i> xenograft models, LOAd703 efficiently reduced established tumors and could be combined with gemcitabine for additional effect. Infected stellate and tumor cells reduced factors that promote tumor growth (Spp-1, Gal-3, HGF, TGFβ and collagen type I), while chemokines were increased. Molecules involved in lymphocyte migration were upregulated on infected endothelial cells. Dendritic cells were robustly stimulated by LOAd703 to produce costimulators, cytokines and chemokines, and such DCs potently expanded both antigen-specific T cells and NK cells.<b>Conclusions:</b> LOAd703 is a potent immune activator that modulates the stroma to support antitumor responses. <i>Clin Cancer Res; 23(19); 5846-57. ©2017 AACR</i>.
From the electromagnetic pulse to high-power electromagnetics (1992)

Since the 1960s significant effort has gone into developing requisite technology for the nuclear electromagnetic pulse (EMP). In the late 1970s several important summary documents were published. The author updates this information to the present. It is noted that EMP has affected a set of related areas which can be collectively referred to as high-power electromagnetics (HPE). This includes direct-strike lightning, high-power microwaves (HPM), and some aspects of transient radar.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Downstream microwave plasma-enhanced chemical vapor deposition of oxide using tetraethoxysilane (1990)

In this paper, results for dielectric oxide films deposited using downstream microwave plasma-enhanced chemical vapor deposition in the temperature range between 250 and 400 °C are presented. The deposition of oxide using TEOS (tetraethoxysilane)+O2 and TEOS+N2O chemistries are studied. In the reactor, the TEOS is injected directly into the deposition chamber without passing through the discharge. Only He, O2, or N2O are fed through the microwave cavity where the discharge is generated. In addition, no ions but chemically active species are present in the deposition chamber during the deposition. The deposition rate is found to decrease with increasing temperature. In addition, it appears that the deposition rate increases with increasing concentration of active oxygen species in the deposition chamber. These suggest that the generation of intermediate species of TEOS and adsorption/desorption of the reactant on the surface are the key steps that determine the deposition rate. The stress of the deposited oxide films is found to be tensile and less than 2×109 dyn/cm2. The Si-OH concentration in the films is found to be low and can be below the detection limit of infrared spectrometry by increasing the flow ratio of O2/TEOS during the deposition. The step coverage of the oxide films over the Al runners is found to be excellent due to the long diffusion time available for TEOS surface species before forming SiO2. The mechanisms of oxide deposition using TEOS+O2 and SiH4+N2O chemistries are studied and compared. The details of oxide step coverage versus different deposition processes are also discussed.
Radioactive Waste Forms for the Future (1988)

This volume presents a compilation of important information on the full range of radioactive waste forms that have been developed, or at least suggested, for the incorporation of high-level nuclear waste. Many of the results were published in the 'gray literature' of final reports of national laboratories or in various, generally less available, proceedings volumes. This is the first publication to draw information on nuclear waste forms for high-level wastes togehter into a single volume. A detailed presentation is given on the properties and performance of non-crystalline waste forms (borosilicate glass, sintered glass, sintered glass, and lead-iron phosphate glass), and crystalline waste forms (Synroc, tailored ceramics, TiO/sub 2/-ceramic matrix, glass-ceramics and concrete). A chapter on Novel waste forms reviews a number of methods that warrant further development because of their potential superior performance and unique applications. The final chapter includes a tabulated comparison of important waste form properties and an extended discussion on the corrosion process and radiation damage effects for each waste form. Of particular interest is a performance assessment of nuclear waste borosilicate glass and the crystalline ceramic Synroc. This is the first detailed attempt to compare these two important waste forms on the basis of their materials properties. The discussion emphasizes the difficulties in making such a comparison and details the types of data that are required. (author). refs.; figs.; tabs.
Polypeptide Chain Structure of Rabbit Immunoglobulins. I. γG-Immunoglobulin<sup>*</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolypeptide Chain Structure of Rabbit Immunoglobulins. I. γG-Immunoglobulin*Parker A. Small, Jr. and Michael E. LammCite this: Biochemistry 1966, 5, 1, 259–267Publication Date (Print):January 1, 1966Publication History Published online1 May 2002Published inissue 1 January 1966https://pubs.acs.org/doi/10.1021/bi00865a034https://doi.org/10.1021/bi00865a034research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts