gebhart/patrepeval huggingface dataset:
Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells (2006)

Platelet 12-lipoxygenase (P-12-LOX) is overexpressed in different types of cancers, including prostate cancer, and the level of expression is correlated with the grade of this cancer. Arachidonic acid is metabolized by 12-LOX to 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE], and this biologically active metabolite is involved in prostate cancer progression by modulating cell proliferation in multiple cancer-related pathways inducing angiogenesis and metastasis. Thus, inhibition of P-12-LOX can reduce these two processes. Several lipoxygenase inhibitors are known, including plant and mammalian lipoxygenases, but only a few of them are known inhibitors of P-12-LOX. Curcumin is one of these lipoxygenase inhibitors. Using a homology model of the three-dimensional structure of human P-12-LOX, we did computational docking of synthetic curcuminoids (curcumin derivatives) to identify inhibitors superior to curcumin. Docking of the known inhibitors curcumin and NDGA to P-12-LOX was used to optimize the docking protocol for the system in study. Over 75% of the compounds of interest were successfully docked into the active site of P-12-LOX, many of them sharing similar binding modes. Curcuminoids that did not dock into the active site did not inhibit P-12-LOX. From a set of the curcuminoids that were successfully docked and selected for testing, two were found to inhibit human lipoxygenase better than curcumin. False-positive curcuminoids showed high LogP (theoretical) values, indicating poor water solubility, a possible reason for lack of inhibitory activity or/and nonrealistic binding. Additionally, the curcuminoids inhibiting P-12-LOX were tested for their ability to reduce sprout formation of endothelial cells (in vitro model of angiogenesis). We found that only curcuminoids inhibiting human P-12-LOX and the known inhibitor NDGA reduced sprout formation. Only limited inhibition of sprout formation at approximately IC(50) concentrations has been seen. At IC(50), a substantial amount of 12-HETE can be produced by lipoxygenase, providing a stimulus for angiogenic sprouting of endothelial cells. Increasing the concentration of lipoxygenase inhibitors above IC(50), thus decreasing the concentration of 12(S)-HETE produced, greatly reduced sprout formation for all inhibitors tested. This universal event for all tested lipoxygenase inhibitors suggests that the inhibition of sprout formation was most likely due to the inhibition of human P-12-LOX but not other cancer-related pathways.
Clearing Land for Farmland and Fuel in the Ancient Near East (1990)

In a wooded region, clearing land of trees is probably the simplest way to expand farmland and provide fuel for a growing population.As long as there is sufficient wooded land people will be able to collect fuel.As land clearance proceeds, it will take more effort to collect fuel.Vegetation Joss may lead to a permanent drop in the water table, increased runoff and wind erosion, and loss of seed sources for vegetation renewal.Such processes ultimately transform the landscape.Continued disturbance may eventually necessitate changes in settlement, agricultural production, and fuel procurement.These forces are clearly at work in today's world, but dramatic changes in the landscape are by no means restricted to modern times.For example, a recent study of environmental change in the southwestern United States showed that periodic abandonment of Anasazi villages resulted from the depletion of fuel resources near settlements, and that local changes induced by tree cutting, along with population growth, may eventually have led to agricultural intensification (Kobler and Matthews 1988).Land clearance can have a variety of effects, many of which leave traces in the archaeological record.In the Near East, people have been actively modifying the vegetation formillennia (Kohler-Rollefson 1988;Miller 1991).The pace of change probably quickened during times of population expansion in areas of intensive settlement, and the third millennium B .C. was such a time.Although it is difficult to date episodes of land clearance, we can use several lines of evidence to trace landscape change, including texts (Rowton 1967;Hansman 1976) and sedimentology (Diester-Haass 1973; Ntitzel 1976).AlthoughDiester-Haass attributes increased sedimentation in the Gulf to climate changes, one can easily imagine that deforestation in the Tigris-Euphrates drainage caused increased runoff and erosion.Archaeological and pollen evidence discussed below yields further evidence of deforestation.Wood was cut primarily to create agricultural fields and to provide fuel for domestic and industrial
REACTIONS OF 1H-2,3-DIKETOPYRIDO[4,3,2-de] QUINOLINE WITH ACETONE AND ACETOPHENONE: A NOVEL SYNTHESIS OF THE ISOQUINOLINO[6,5,4,3-cde]QUINOLINE NUCLEUS (1998)

Article REACTIONS OF 1H-2,3-DIKETOPYRIDO[4,3,2-de] QUINOLINE WITH ACETONE AND ACETOPHENONE: A NOVEL SYNTHESIS OF THE ISOQUINOLINO[6,5,4,3-cde]QUINOLINE NUCLEUS was published on December 1, 1998 in the journal Heterocyclic Communications (volume 4, issue 6).
AspectBrowser for Eclipse (2004)

A powerful feature of Eclipse is its plug-in architecture for incorporating third-party tools. An important source of plug-ins is standalone tools that were developed prior to the release of Eclipse. However, such tools inevitably incorporate features that Eclipse provides natively, requiring rework to rehost those features to Eclipse.In our retarget of the AspectBrowser application to Eclipse, we found not only an unexpected number of deeply ingrained features that needed to be rehosted, but also numerous GUI and architectural mismatches between AspectBrowser's version of these features and Eclipse's. By judiciously resolving these issues, we were able to minimize their impact on the AspectBrowser base code, and still reap significant benefits from Eclipse's high level of plug-in integration. For example, AspectBrowser is able to function as a viewer for any existing plug-in that produces Eclipse resource markers.This paper describes the insights gained from retargeting AspectBrowser to Eclipse and provides guidelines to those retargeting tools to Eclipse. We also reflect on the importance of recent improvements to Eclipse in this process, and what additional improvements could be made.
Test methods useful in selecting materials for outdoor high voltage insulation (1973)

The availability of acceptable outdoor insulators that will meet the electrical and mechanical requirements for EHV transmission systems presents a complex and unsolved problem. A considerable effort has been spent toward developing a single material with suitable mechanical strength and long-term insulating stability. The unlikelihood of finding such a material has prompted the concept of a composite insulator where two materials are combined to perform the total insulator function, one for mechanical strength and the other for surface stability and long term electrical insulation. This paper deals with the electrical insulating function and classification of materials best suited for outdoor insulators based on their surface behavior in a high voltage and simulated wet, outdoor environment.
Integration technology for MEMS automotive sensors (2003)

MEMS (microelectromechanical systems) is an enabling technology that has been used in high volume automotive applications such as pressure sensors and accelerometers for a variety of applications such as that control the engine performance as well as the safety of the occupants. MEMS sensors require an interface circuit to convert the input mechanical signal to the equivalent electrical signal that is used to generate the required control function. The integration of the MEMS sensor with the interface circuit can be achieved either in the same piece of silicon or in the package. The challenges in this integration are discussed in the paper with specific examples for piezoresistive pressure sensors, capacitive accelerometers and capacitive pressure sensors. The effects of the application environment on the performance of these sensors are also discussed in the paper. Examples of system partitioning and integration are described using a satellite accelerometer system and a tire pressure monitoring system.
Differential modulation of the effects of lipopolysaccharide on macrophages by a major outer membrane protein of <i>Proteus mirabilis</i>. (1993)

We previously showed that a major protein isolated from purified cell walls of Proteus mirabilis (39-kDa protein) is a strong modulator of the specific immune responses to LPS from this bacterium in mice. When mixed with LPS before immunization, this protein enhances T cell-dependent, IgG antibody-producing cell responses specific for LPS. Furthermore, complexes of the 39-kDa protein with LPS drastically inhibit the production of oxygen radicals by murine macrophages activated with LPS, as measured in a chemiluminescence assay. In the present report, we have further investigated possible modulating effects of the protein at the level of LPS-macrophage interaction. When mixed with LPS, the 39-kDa protein inhibited IL-1 production by murine macrophages derived from bone marrow in a dose-dependent manner, as determined in an IL-2-dependent IL-1 assay. On the other hand, the protein had little effect on LPS-mediated suppression of MHC class II expression on the surface of macrophages induced with IFN-gamma. Some abrogation of suppression was observed, but the amounts of protein needed for this effect were quite large, in comparison with the amounts rendering inhibition of IL-1 production. In contrast, the 39-kDa protein enhanced the LPS-induced cytotoxicity of macrophages against L929 target cells, primarily as the result of production of TNF. These results show that the 39-kDa protein is a potent modulator of the interaction of LPS with macrophages, exerting its effects in a differential manner with respect to various parameters of LPS-induced activation of macrophages.
Approximate XML joins (2002)

XML is widely recognized as the data interchange standard for tomorrow, because of its ability to represent data from a wide variety sources. Hence, XML is likely to be the format through which data from multiple sources is integrated.In this paper we study the problem of integrating XML data sources through correlations realized as join operations. A challenging aspect of this operation is the XML document structure. Two documents might convey approximately or exactly the same information but may be quite different in structure. Consequently approximate match in structure, in addition to, content has to be folded in the join operation. We quantify approximate match in structure and content using well defined notions of distance. For structure, we propose computationally inexpensive lower and upper bounds for the tree edit distance metric between two trees. We then show how the tree edit distance, and other metrics that quantify distance between trees, can be incorporated in a join framework. We introduce the notion of reference sets to facilitate this operation. Intuitively, a reference set consists of data elements used to project the data space. We characterize what constitutes a good choice of a reference set and we propose sampling based algorithms to identify them. This gives rise to a variety of algorithmic approaches for the problem, which we formulate and analyze. We demonstrate the practical utility of our solutions using large collections of real and synthetic XML data sets.
Motion-Compensated SAR Image ISLR (1987)

The integrated sidelobe ratio (ISLR) arising from errors in motion compensation is one figure-of-merit in evaluating the fidelity of modern SAR imagery. An analytical closed-form expression is derived here as a function of SAR array time, underlying motion-sensor accuracy, and limiting data bandwidth.
Porous silica pellicle frame for deep UV lithography (2002)

Several significant technical issues are associated with the current anodized aluminum photomask frame. These problems will become more acute as shorter wavelengths such as 193 nm and 157 nm become standard. For example, it is difficult to purge the pellicle space, and the non-porous nature of the aluminum frame can lead to pressure-induced film breakage. In addition, the thermal expansion behavior of aluminum does not match that of the silica substrate, which can lead to pattern distortion or bending of a hard pellicle film. Proposed solutions such as a perforated silica frame or a porous stainless steel frame may address some of these issues, but a complete solution has not been forthcoming. A porous silica frame technology based on sol-gel processing may eliminate concerns associated with the lack of porosity in the stainless steel frame, as well as thermal expansion mismatch problems. Several additional advantages may also be realized, including the removal of organic contaminants from inside the pellicle space, filtration of particulate contaminants, and stability under aggressive cleaning. This approach to a porous silica frame may help enable a cost-effective route to more rapid commercialization of shorter-wavelength microlithographic processes.
Raman study of layered rock-salt LiCoO2 and its electrochemical lithium deintercalation (1997)

Unpolarized and polarized Raman spectra (200–800 cm-1) of LiCoO2 with a layered rock-salt structure were measured. The Raman-active lattice modes of LiCoO2 were assigned by polarized Raman measurements of a c-axis oriented thin film. The variation of the Raman spectra of Li1-xCoO2 powder prepared by electrochemical lithium deintercalation was investigated, and the spectral changes were well correlated with the structural changes determined by x-ray diffraction except that peak splitting by the distortion in the monoclinic phase was not observed. The observed line broadening of the second hexagonal phase and the monoclinic phase indicated that the lithium ions remaining in the lattice after deintercalation randomly occupy the available sites on the lithium planes in the lattice the layered rock-salt structure. © 1997 John Wiley & Sons, Ltd.
Identification of a complex control object with frequency characteristics obtained experimentally with its dynamic neural network model (2015)

We solve the identification problem for “input-output” transmission channels of complex control objects that represent technological systems with continuous production in chemical, metal processing, mining, paper, and other industries, with neural networks. The resulting model represented with a dynamical neural network models the behavior of the technological object and lets us find the object’s output, including outputs for periodic test influences. By the resulting complex frequency response, with the method of least squares we find the parameters of the channel’s transfer function. We show an example of identification for “input-output” channels with a delay of the imitational object under random noise at the input.
Generating Market Basket Data with Temporal Information (2001)

This paper presents a synthetic data generator that outputs timestamped transactional data with embedded temporal patterns controlled by a set of input parameters. In particular, calendar schema, which is determined by a hierarchy of input time granularities, is used as a framework of possible temporal patterns. An example of calendar schema is (year, month, day), which provides a framework for calendar-based temporal patterns of the form\t -38352 , where each is either an integer or the symbol . For example, \t\t is such a pattern, which corresponds to the time intervals consisting of all the 16th days of all months in year 2000. This paper also evaluates the data generator through a series of experiments. The synthetic data generator is intended to provide support for data mining community in evaluating various aspects (especially the temporal aspects and the scalability) of data mining algorithms.
Plasma TIMP‐1—a marker of metastasis in colorectal cancer (2000)

TIMP-1 and MMP-9 levels were significantly elevated in the plasma of patients with colorectal cancer. Metastatic disease is associated with significantly higher plasma TIMP-1 than is localized disease. Sampling of portal blood is of no additional benefit when measuring MMP-9 enzyme levels in colorectal cancer.
Glycogen Synthase Kinase 3β (GSK3β) Regulates Differentiation and Proliferation in Neural Stem Cells from the Rat Subventricular Zone (2007)

On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3β (GSK3β) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/β-catenin signaling pathway appear to participate in enhanced neuronal differentiation and activated transcription of β-catenin target genes during GSK3β inhibition, associated with decreased apoptosis. Keywords: Neural stem cell • Neurosphere • Glycogen Synthase Kinase 3β • Two-dimensional gel electrophoresis • Rat • Subventricular zone
Luminescence during the Anodic Oxidation of Silicon (1964)

Silicon wafers were anodized in ethylene glycol containing . Luminescence, measured with a photomultiplier, began with oxide growth and, at constant current, increased with some low power of the voltage, the power depending on the type and resistivity of the silicon. When anodization was interrupted on low resistivity silicon and the voltage and current were decreased, then increased again, the luminescence was exponential with the voltage and linear with the current during this excursion. Initially, both the luminescence and the oxide growth on n‐type silicon of moderate or high resistivity were patchy; the patches gradually came together to form a uniform layer. With p‐type material the light emission was uniform even at the start. At the highest voltages, breakdown occurred with the appearance of "sparks," which involve electrical discharge from the wafer into the solution
The Role of Neuropeptide Y in the Progesterone-Induced Luteinizing Hormone-Releasing Hormone Surge in Vivo in Ovariectomized Female Rhesus Monkeys* (2000)

Progesterone induces a LHRH surge in estrogen-primed ovariectomized rhesus monkeys, with a concomitant increase in the pulse frequency of neuropeptide Y (NPY) release. However, the role for NPY in the positive feedback action of progesterone on LHRH release in primates is unknown. The present study examines the effect of an antisense oligodeoxynucleotide for NPY messenger RNA (AS NPY) on the progesterone-induced LHRH surge in vivo using push-pull perfusion. The AS NPY was directly infused into the stalk-median eminence (S-ME), whereas perfusates were collected for assessment of LHRH release. For a control, a scrambled oligodeoxynucleotide was infused. The results indicate that 1) the scrambled oligodeoxynucleotide did not interfere with the progesterone-induced LHRH surge, 2) whereas AS NPY blocked the progesterone-induced increase in LHRH release, and 3) no LHRH surges were induced by oil as a control for progesterone, but the AS NPY also reduced LHRH release in oil controls. These data suggest that 1) AS NPY infusion into the S-ME results in reduction in LHRH release; and 2) NPY release in the S-ME is important for the positive feedback effects of progesterone on LHRH release in estrogen-primed ovariectomized monkeys.
In Vitro Diffusion Studies of Ketoprofen Transdermal Therapeutic Systems (1995)

The release of Ketoprofen from the matrix model of TTS were studied. It may be concluded that the pharmaceutical availability of the drug can be regulated by the type and thickness of the matrix. Quantitation of the active agent in the dissolution medium was done by UV-spectroscopy.The results obtained by the rotating cylinder method were compared to another method utilizing a modified Stricker cell.
A Combined Solid-State NMR and Synchrotron X-ray Diffraction Powder Study on the Structure of the Antioxidant (+)-Catechin 4.5-hydrate. (2010)

Analyses combining X-ray powder diffraction (XRD) and solid-state NMR (SSNMR) data can now provide crystal structures in challenging powders that are inaccessible by traditional methods. The flavonoid catechin is an ideal candidate for these methods, as it has eluded crystallographic characterization despite extensive study. Catechin was first described nearly two centuries ago, and its powders exhibit numerous levels of hydration. Here, synchrotron XRD data provide all heavy-atom positions in (+)-catechin 4.5-hydrate and establish the space group as C2. SSNMR data ((13)C tensor and (1)H/(13)C correlation) complete the conformation by providing catechin's five OH hydrogen orientations. Since 1903, this phase has been erroneously identified as a 4.0 hydrate, but XRD and density data establish that this discrepancy is due to the facile loss of the water molecule located at a Wyckoff special position in the unit cell. A final improvement to heavy-atom positions is provided by a geometry optimization of bond lengths and valence angles with XRD torsion angles held constant. The structural enhancement in this final structure is confirmed by the significantly improved fit of computed (13)C tensors to experimental data.
Synthesis and binding properties of basket-shaped hosts (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and binding properties of basket-shaped hostsJan W. H. Smeets, Rint P. Sijbesma, Lydia Van Dalen, Anthony L. Spek, Wilberth J. J. Smeets, and Roeland J. M. NolteCite this: J. Org. Chem. 1989, 54, 15, 3710–3717Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/jo00276a037https://doi.org/10.1021/jo00276a037research-articleACS PublicationsRequest reuse permissionsArticle Views626Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Monitoring Service Chains in the Cloud (2016)

Service chaining in the cloud is a new trend that network operators are moving towards. Service chaining in the cloud, is the process of virtualizing various services in the cloud instances and linking them together in order to create a chain of services. Aside from the benefits that it provides for the subscribers and network operators, it needs further considerations to be fully applied and utilized. Since service availability is a key concern for network provider and operators, the availability of service chain requires careful attention.\n \nThe goal of this thesis work is to investigate how to monitor service functions that form the service chain in the cloud. By monitoring the service functions we aim to inspect the running services and report occurrence of abnormality (i.e. heavy work load), to our main monitoring platform, in order to trigger corresponding operations. We believe with monitoring the services we can increase their availability with low overhead. Our main contribution in this work, is to build a platform that can control and monitor the services in the cloud in order to enhance their availability.