gebhart/patrepeval huggingface dataset:
프로그램 논리모형을 활용한 경력단절여성 재취업지원 프로그램 효과성 분석 - 서울시 S센터 사례를 중심으로 - (2014)

이 연구는 프로그램 논리모형을 활용하여 경력단절여성의 재취업지원 프로그램의 효과성을 분석하려는 시도이다. 프로그램 논리모형을 적용하여 기존의 결과 중심의 재취업지원 프로그램 평가에서 보지 못한 프로그램집행과 결과, 결과 사이의 연계성을 탐색함으로써 프로그램의 효과를 검증하고자 하였다. 일차적으로 선행연구 및 평가 문헌 검토를 통해 재취업지원 프로그램의 효과검증을 위한 틀을 구안하였고, 논리모형에 기초하여 프로그램 집행과 결과 단계를 분석하였다. 이차적으로는 결과 단계 간의 연결고리를 확인하기 위하여 프로그램 참여자를 대상으로 한 심층 면담 결과를 토대로 효과를 분석하였다. 연구 결과, 참여자는 경력단절여성 재취업지원 프로그램을 통해 취업준비역량 및 구직 효능감을 증대시킬수 있었고 그 결과가 취업률 향상이라는 고용효과로 나타났다. 최초결과 이후 참여자들이 보이는 인식과 태도, 행동의 변화는 고용유지 효과에 영향을 미치고 있음을 알 수 있었다.
Calculation Method for the Cable Zone Beams of a Single Cable Plane Low-Pylon Cable-Stayed Bridge with a Wide Box Girder (2015)

The researches for cable area beams of single cable plane low-pylon cable-stayed bridge were summarized. Based on plane frame theoretical mechanics, the simplified model for cable area beams of single cable plane low-pylon cable-stayed bridge with wide box girder is elaborated; and mechanical characteristics of the cable zone beams were studied by changing the structural properties. The conclusions have some reference values.
Directed cell growth and alignment on protein-patterned 3D hydrogels with stereolithography (2012)

The stereolithography apparatus (SLA) is a computer-assisted, three-dimensional (3D) printing system that is gaining attention in the medical field for the fabrication of patient-specific prosthetics and implants. An attractive class of implantable biomaterials for the SLA is photopolymerisable hydrogels because of their resemblance to soft tissues and intrinsic support of living cells. However, most laser-based SLA machines lack the minimum feature size required to imitate cell growth and alignment patterns in complex tissue architecture. In this study, we demonstrate a simple method for aligning cells on 3D hydrogels by combining the micro-contact printing (µCP) technique with the stereolithographic process. Fibronectin modified with acrylate groups was printed on glass coverslips with unpatterned, 10, 50, and 100 µm wide line patterns, which were then transferred to hydrogels through chemical linkages during photopolymerisation. Fibroblasts cultured on protein-printed 3D hydrogels aligned in the direction of the patterns, as confirmed by fast Fourier transform and cell morphometrics.
SCD's cooled and uncooled photo detectors for NIR SWIR (2012)

Short wavelength Infra Red (SWIR) imaging has gained considerable interest in recent years. The main applications among others are: active imaging and LADAR, enhanced vision systems, low light level imaging and security surveillance systems. In this paper we will describe SCD's considerable efforts in this spectral region, addressing several platforms: 1. Extension of the mature InSb MWIR product line operating at 80K (cut-off wavelength of 5.4μm). 2. Extension of our new XB<sub>n</sub><i>n</i> InAsSb "bariode" technology operating at 150K (cut-off of 4.1μm). 3. Development of InGaAs detectors for room temperature operation (cut-off of 1.7μm) 4. Development of a SNIR ROIC with a low noise imaging mode and unique laser-pulse detection modes. In the first section we will present our latest achievements for the cooled detectors where the SWIR region is combined with MWIR response. Preliminary results for the NIR-VIS region are presented where advanced substrate removal techniques are implemented on flip-chip hybridized focal plane arrays. In the second part we will demonstrate our VGA, 15μm pitch, InGaAs arrays with dark current density below 1.5nA/cm<sup>2</sup> at 280K. The InGaAs array is hybridized to the SNIR ROIC, thus offering the capability of low SWaP systems with laser-pulse detection modes.
Shoe Modifications in Lower-Extremity Orthotics (2013)

INTRODUCTION The art and science of correcting foot deformities is still a mixture of tradition, artisan skill, clinical experience, and the prescribing doctor's professional convictions. Although it is the orthotist's duty to discuss with the orthopedist any questionable aspects of a prescription, it is obviously not his privilege to countermand the doctor's judgment in the matter. It must also be understood that a foot deformity is not to be taken as an unalterable fact until all methods of relief, such as physiotherapy and surgery, have been full explored. The orthotist must also appreciate the fact that the basic principles of foot correction have yet to be agreed upon by anatomists or orthopedists. Some specialists even dispute the location of the arches. In spite of controversy, however, the orthotist must properly implement the prescription as given him by the orthopedic surgeon, otherwise, his knowledge of shoe modifications will be of little value to the patient. Not included in this presentation are the foot problems of the infant, the adolescent, and adult females. Based upon an intra-VA lecture, the material presented here quite naturally applies primarily to the adult male. PURPOSE OF SHOES AND MODIFICATIONS Originally shoes were a simple covering used to protect the foot from sharp stones and thorns and from the uncomfortable vagaries of the weather. As with other forms of body covering, it was not long before footwear became embellished with decorative effects and acquired a function in overall cosmesis and social acceptability. In terms of locomotion, however, the shoe is basically a means of weight transfer to the ground. Today's shoe, with its relatively light upper part, a stiff or thick sole and heel, and an almost flat insole and outsole, provides the normal foot with adequate support and purchase upon the ground. With proper modifications, shoes can also be made to afford the deformed foot protection, cosmesis, and better balance for standing and walking. Indeed, the main purpose of all shoe modifications is the restoration of as normal a gait and weight-bearing pattern as is possible for the patient. Shoe modifications are even more important when fitting the person who must wear a leg brace. A brace can be made to fit the patient beautifully and to function perfectly, but is effectiveness will be lost if the orthotist has overlooked the correct construction of the shoe or the factors necessary for functional weight-bearing. …
Polygonal tundra geomorphological change in response to warming alters future <scp>CO</scp><sub>2</sub> and <scp>CH</scp><sub>4</sub> flux on the Barrow Peninsula (2014)

The landscape of the Barrow Peninsula in northern Alaska is thought to have formed over centuries to millennia, and is now dominated by ice-wedge polygonal tundra that spans drained thaw-lake basins and interstitial tundra. In nearby tundra regions, studies have identified a rapid increase in thermokarst formation (i.e., pits) over recent decades in response to climate warming, facilitating changes in polygonal tundra geomorphology. We assessed the future impact of 100 years of tundra geomorphic change on peak growing season carbon exchange in response to: (i) landscape succession associated with the thaw-lake cycle; and (ii) low, moderate, and extreme scenarios of thermokarst pit formation (10%, 30%, and 50%) reported for Alaskan arctic tundra sites. We developed a 30 × 30 m resolution tundra geomorphology map (overall accuracy:75%; Kappa:0.69) for our ~1800 km² study area composed of ten classes; drained slope, high center polygon, flat-center polygon, low center polygon, coalescent low center polygon, polygon trough, meadow, ponds, rivers, and lakes, to determine their spatial distribution across the Barrow Peninsula. Land-atmosphere CO2 and CH4 flux data were collected for the summers of 2006-2010 at eighty-two sites near Barrow, across the mapped classes. The developed geomorphic map was used for the regional assessment of carbon flux. Results indicate (i) at present during peak growing season on the Barrow Peninsula, CO2 uptake occurs at -902.3 10(6) gC-CO2 day(-1) (uncertainty using 95% CI is between -438.3 and -1366 10(6) gC-CO2 day(-1)) and CH4 flux at 28.9 10(6) gC-CH4 day(-1) (uncertainty using 95% CI is between 12.9 and 44.9 10(6) gC-CH4 day(-1)), (ii) one century of future landscape change associated with the thaw-lake cycle only slightly alter CO2 and CH4 exchange, while (iii) moderate increases in thermokarst pits would strengthen both CO2 uptake (-166.9 10(6) gC-CO2 day(-1)) and CH4 flux (2.8 10(6) gC-CH4 day(-1)) with geomorphic change from low to high center polygons, cumulatively resulting in an estimated negative feedback to warming during peak growing season.
Ein einfacher Zugang zu PQQ (1993)

An Easy Access to PQQ A novel and short synthesis of PQQ , the cofactor of quinoproteins and maybe a vitamine, starting from the known cumarin 6 without any chromatographic purification of the intermediates is described.
Utilization of n-Paraffins and Vitamin B6 Production by Pichia guilliermondii Wickerham (1973)

The accumulation of vitamin B6 by Pichia guilliermondii Wickerham NK–2 strain grown on hydrocarbon was investigated. Ammonium acetate was more effective than other nitrogen sources tested. Satisfactory utilization by the yeast strain was observed in n-alkanes of C10–C18, and n-pentadecane was the best for vitamin B6 production. Vitamin B6 was excreted in the cultural broth mainly in the form of pyridoxal, The maximal vitamin B6 production was approximately 25 mg per liter of the culture broth.
Oxidoreduction in Chloroplasts (1951)

Introduction Production of Oxygen by Cell-Free Preparation Oxygen-Producing Reaction of the Chloroplast Some Properties of the Photochemically Active Chloroplast Material Properties of the Elements Iron and Magnesium in Tetrapyrrolic Compounds Hematin Compounds of Leaves and Cytochrome f Effect of Inhibitors on Production of Oxygen by Illuminated Chloroplasts Reducing Properties of Chloroplasts Relation of the Chloroplast Reaction to Photosynthesis
Flow and Drag Formulas for Simple Quadrics (1927)

The pressure distribution and resistance found by theory and experiment for simple quadrics fixed in an infinite uniform stream of practically incompressible fluid are calculated. The experimental values pertain to air and some liquids, especially water; the theoretical refer sometimes to perfect, again to viscid fluids. Formulas for the velocity at all points of the flow field are given. Pressure and pressure drag are discussed for a sphere, a round cylinder, the elliptic cylinder, the prolate and oblate spheroid, and the circular disk. The velocity and pressure in an oblique flow are examined.
Androgen receptor antagonists compromise T cell response against prostate cancer leading to early tumor relapse (2016)

Surgical and medical androgen deprivation therapy (ADT) is a cornerstone for prostate cancer treatment, but relapse usually occurs. We herein show that orchiectomy synergizes with immunotherapy, whereas the more widely used treatment of medical ADT involving androgen receptor (AR) antagonists suppresses immunotherapy. Furthermore, we observed that the use of medical ADT could unexpectedly impair the adaptive immune responses through interference with initial T cell priming rather than in the reactivation or expansion phases. Mechanistically, we have revealed that inadvertent immunosuppression might be potentially mediated by a receptor shared with γ-aminobutyric acid. Our data demonstrate that the timing and dosing of antiandrogens are critical to maximizing the antitumor effects of combination therapy. This study highlights an underappreciated mechanism of AR antagonist-mediated immunosuppression and provides a new strategy to enhance immune response and prevent the relapse of advanced prostate cancer.
Mechanisms of Reinforcement of Elastomers by Polymeric Fillers (1971)

Two systems have recently been studied involving elastomeric networks reinforced by finely divided glassy polymeric fillers. One of these was prepared by blending latices of polystyrene, or other glassy polymers, with SBR, and vulcanizing the resulting elastomer. It was found that the tensile strength of the SBR increased with higher filler content, lower particle size, and increase in rigidity of the filler and was virtually unaffected by filler-elastomer bonds. The other system studied consisted of the "thermoplastic elastomers" prepared from styrene-diene-styrene triblock polymers. Here the polystyrene forms small "domains" (∼200 A) which act both as network junctions and reinforcing filler. These glassy particles yield at high stresses, thus relieving high stress concentrations and resulting in high tensile strength but large inelastic deformations.
How Many “New” Entities Can Be Created from One Active Substance? The Case of Cyclosporin A (2003)

The existence of various crystalline forms of active substances, which can potentially differ in their pharmacokinetic profile, bioavailability or stability, creates the possibility of extending the patent protection of “old” substances utilizing the structures of new crystalline forms. Using cyclosporin A as an example, this report points to the fact that even with relatively small molecules, having about 60 non-hydrogen atoms, the number of “new” entities that can be generated can be at times nearly infinite.
Automatic blood cell classification based on joint histogram based feature and bhattacharya kernel (2008)

We propose a blood cell classification method with the aim of designing an automatic differential blood count system, which can help cancer diagnosis. The proposed system contains two automated steps: an active contour-based segmentation of blood cells from microscopy images and their classification. For classification we investigate several joint histogram-based features extracted from the segmented blood cells. We use support vector machine with a proposed kernel based on the Bhattacharya coefficient of joint histograms. Experimental results show the effectiveness of our system. Furthermore, comparative study illustrates that the proposed system outperforms other existing classification approaches in terms of classification accuracy.
High-throughput imaging of neuronal activity in <i>Caenorhabditis elegans</i> (2013)

Neuronal responses to sensory inputs can vary based on genotype, development, experience, or stochastic factors. Existing neuronal recording techniques examine a single animal at a time, limiting understanding of the variability and range of potential responses. To scale up neuronal recordings, we here describe a system for simultaneous wide-field imaging of neuronal calcium activity from at least 20 Caenorhabditis elegans animals under precise microfluidic chemical stimulation. This increased experimental throughput was used to perform a systematic characterization of chemosensory neuron responses to multiple odors, odor concentrations, and temporal patterns, as well as responses to pharmacological manipulation. The system allowed recordings from sensory neurons and interneurons in freely moving animals, whose neuronal responses could be correlated with behavior. Wide-field imaging provides a tool for comprehensive circuit analysis with elevated throughput in C. elegans.
Electrophoresis (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrophoresisRichard D. StricklandCite this: Anal. Chem. 1970, 42, 5, 32–57Publication Date (Print):April 1, 1970Publication History Published online1 May 2002Published inissue 1 April 1970https://pubs.acs.org/doi/10.1021/ac60287a015https://doi.org/10.1021/ac60287a015research-articleACS PublicationsRequest reuse permissionsArticle Views236Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High frequency modeling of interconnects in deep-submicron technologies (2003)

In this paper, we evaluate the suitable level of modeling for interconnects in deep sub-micron circuits. We propose high frequency models for transmission lines and crosstalk. Our method is based on the association of electromagnetic (EM) and electrical simulations. We validate the principle of this method by comparisons with time domain characterizations. In particular, we analyze the role of the ground configuration in the mechanisms of crosstalk.
Atomistic details of the associative phosphodiester cleavage in human ribonuclease H (2010)

During translation of the genetic information of DNA into proteins, mRNA is synthesized by RNA polymerase and after the transcription process degraded by RNase H. The endoribonuclease RNase H is a member of the nucleotidyl-transferase (NT) superfamily and is known to hydrolyze the phosphodiester bonds of RNA which is hybridized to DNA. Retroviral RNase H is part of the viral reverse transcriptase enzyme that is indispensable for the proliferation of retroviruses, such as HIV. Inhibitors of this enzyme could therefore provide new drugs against diseases like AIDS. In our study we investigated the molecular mechanism of RNA cleavage by human RNase H using a comprehensive high level DFT/B3LYP QM/MM theoretical method for the calculation of the stationary points and nudged elastic band (NEB) and free energy calculations to identify the transition state structures, the rate limiting step and the reaction barrier. Our calculations reveal that the catalytic mechanism proceeds in two steps and that the nature of the nucleophile is a water molecule. In the first step, the water attack on the scissile phosphorous is followed by a proton transfer from the water to the O2P oxygen and a trigonal bipyramidal pentacoordinated phosphorane is formed. Subsequently, in the second step the proton is shuttled to the O3' oxygen to generate the product state. During the reaction mechanism two Mg(2+) ions support the formation of a stable associated in-line S(N)2-type phosphorane intermediate. Our calculated energy barrier of 19.3 kcal mol(-1) is in excellent agreement with experimental findings (20.5 kcal mol(-1)). These results may contribute to the clarification and understanding of the RNase H reaction mechanism and of further enzymes from the RNase family.
Synthesis and deposition of metal nanoparticles by gas condensation process (2014)

In this work, the synthesis of Pt and Ag nanoparticles by means of the inert gas phase condensation of sputtered atomic vapor is presented. The process parameters (power, sputtering time, and gas flow) were varied in order to study the relationship between deposition conditions and properties of the nanoparticles such as their quantity, size, and size distribution. Moreover, the gas phase condensation process can be combined with a plasma enhanced chemical vapor deposition procedure in order to deposit nanocomposite coatings consisting of metallic nanoparticles embedded in a thin film matrix material. Selected examples of application of the generated nanoparticles and nanocomposites are discussed.
Near-Term Prediction of Sudden Cardiac Death in Older Hemodialysis Patients Using Electronic Health Records (2013)

Subtle changes in the experience of hemodialysis aid in the assessment of sudden cardiac death and are captured by modern electronic health records. The collected data are better for the assessment of near-term risk as opposed to longer-term risk.
Gibberellin‐associated cisgenes modify growth, stature and wood properties in <i>Populus</i> (2010)

Summary We studied the effects on plant growth from insertion of five cisgenes that encode proteins involved in gibberellin metabolism or signalling. Intact genomic copies of Pt GA20ox7, PtGA2ox2,Pt RGL1_1, PtRGL1_2 and PtGAI1 genes from the genome‐sequenced Populus trichocarpa clone Nisqually‐1 were transformed into Populus tremula × alba (clone INRA 717‐1B4), and growth, morphology and xylem cell size characterized in the greenhouse. Each cisgene encompassed 1–2 kb of 5′ and 1 kb of 3′ flanking DNA, as well as all native exons and introns. Large numbers of independent insertion events per cisgene (19–38), including empty vector controls, were studied. Three of the cisgenic modifications had significant effects on plant growth rate, morphology or wood properties. The PtGA20ox7 cisgene increased rate of shoot regeneration in vitro , accelerated early growth, and variation in growth rate was correlated with PtGA20ox7 gene expression. PtRGL1_1 and PtGA2ox2 caused reduced growth, while PtRGL1_2 gave rise to plants that grew normally but had significantly longer xylem fibres. RT‐PCR studies suggested that the lack of growth inhibition observed in PtRGL1_2 cisgenic plants was a result of co‐suppression. PtGAI1 slowed regeneration rate and both PtGAI1 and PtGA20ox7 gave rise to increased variance among events for early diameter and volume index, respectively. Our work suggests that cisgenic insertion of additional copies of native genes involved in growth regulation may provide tools to help modify plant architecture, expand the genetic variance in plant architecture available to breeders and accelerate transfer of alleles between difficult‐to‐cross species.
Data Extraction from Semi-structured Web Pages by Clustering (2006)

This paper introduces an approach to the use of clustering for data extraction from semi-structured Web pages. A variant Hierarchical Agglomerative Clustering (HAC) algorithm K-neighbours-HAC is developed which uses the similarities of the data format (HTML tags) and the data content (text string values) to group similar text tokens into clusters. Using these clusters, similar text tokens are identi- fied as data fields and extracted as target information. The approach is examined and compared with a number of existing information extraction systems on two different sets of web pages and the results suggest that the new approach is effective for web information extraction and that it outperforms all of the existing approaches on these web sites.
Expression of Concern: Bcl‐2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF‐1mediated transcriptional activity (2002)

The aim of this paper was to study the molecular mechanisms by which bcl-2 increases hypoxia-induced vascular endothelial growth factor (VEGF) expression. We demonstrated that bcl-2 overexpression in M14 human melanoma cell line enhances hypoxia-induced VEGF mRNA stability and promoter activation. In particular, the half-life of the message was longer in bcl-2 transfectants (approximately 330 min) than in control cells (approximately 180 min). In addition, bcl-2 overexpression increased VEGF promoter activity through the hypoxia-inducible factor-1 (HIF-1) transcription factor. Increased HIF-1a protein expression and DNA binding activity were detected in bcl-2 overexpressing cells compared with control cells. An enhanced functional activity of secreted VEGF was found both in in vitro and in vivo angiogenic assays, and the use of VEGF specific antibodies validated the role of VEGF on bcl-2-induced angiogenesis. Taken together our results indicate that bcl-2 plays an important role in melanoma angiogenesis, and that VEGF mRNA stabilization and HIF-1-mediated transcriptional activity are two important control points in bcl-2/hypoxia-induced VEGF expression.