gebhart/patrepeval huggingface dataset:
Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues (2010)

Methylation of cytosine residues within the CpG dinucleotide in mammalian cells is an important mediator of gene expression, genome stability, X-chromosome inactivation, genomic imprinting, chromatin structure, and embryonic development. The majority of CpG sites in mammalian cells is methylated in a nonrandom fashion, raising the question of how DNA methylation is distributed along the genome. Here, we focused on the functions of DNA methyltransferase-3b (Dnmt3b), of which deregulated activity is linked to several human pathologies. We generated Dnmt3b hypomorphic mutant mice with reduced catalytic activity, which first revealed a deregulation of Hox genes expression, consistent with the observed homeotic transformations of the posterior axis. In addition, analysis of deregulated expression programs in Dnmt3b mutant embryos, using DNA microarrays, highlighted illegitimate activation of several germ-line genes in somatic tissues that appeared to be linked directly to their hypomethylation in mutant embryos. We provide evidence that these genes are direct targets of Dnmt3b. Moreover, the recruitment of Dnmt3b to their proximal promoter is dependant on the binding of the E2F6 transcriptional repressor, which emerges as a common hallmark in the promoters of genes found to be up-regulated as a consequence of impaired Dnmt3b activity. Therefore, our results unraveled a coordinated regulation of genes involved in meiosis, through E2F6-dependant methylation and transcriptional silencing in somatic tissues.
Characterization of dynamic behavior of flexure-based mechanisms for precision angular alignment (2008)

Angular alignment is a critical requirement in numerous precision motion control applications. Examples include beam-steering in optical communications and tool-sample alignment in imprint lithography. Flexural mechanisms are being widely used in such applications. The absence of non-linearities, including friction and backlash, makes flexural components ideal for achieving atomic-scale resolution. Closed-loop control implementations of flexural angle alignment mechanisms have been attempted in the literature in various cases. Performance limitations in closed-loop control implementations have been characterized traditionally considering effects of actuators, sensors, and control algorithms used. However, a critical limiting factor is imposed by the open-loop response of the plant, i.e. the natural frequencies of the flexural mechanism itself. In this paper, we assemble models for characterizing the dynamic behavior of flexural mechanisms for angular alignment. The performance trade-offs in terms of range, load-capacity, and control bandwidth are highlighted. A state-space formulation is proposed for mapping design performance variables, such as vertical deflection or angular acceleration. The effects on dynamic performance imposed by asymmetry resulting from manufacturing errors are studied.
First Report of “<i>Candidatus</i> Liberibacter solanacearum” Associated with Psyllid-Affected Carrots in Norway (2011)

Carrot (Daucus carota) plants with symptoms resembling those associated with the carrot psyllid Trioza apicalis and the bacterium "Candidatus Liberibacter solanacearum" (1-4) were observed in 70 to 80% of commercial fields and experimental plots in southeastern Norway from late July to mid-September of 2011; all cultivars grown were affected with approximately 10 to 100% symptomatic plants per field. T. apicalis, a pest of carrot in northern and central Europe, including Norway, can cause as much as 100% crop loss and is associated with "Ca. L. solanacearum" (1-4). Symptoms on affected plants include leaf curling, yellow and purple discoloration of leaves, stunted growth of shoots and roots, and proliferation of secondary roots. Carrot plant samples were collected from five T. apicalis-infested fields in Ostfold, Vestfold, Oppland, and Hedmark counties. Total DNA was extracted from petiole and root tissues of 54 plants, including 27 symptomatic plants and 27 asymptomatic plants from four cultivars (Namdal, Panther, Romance, and Yukon) with the cetyltrimethylammonium bromide (CTAB) buffer extraction method (2,3). DNA samples were tested by PCR assay using primer pairs OA2/OI2c and CL514F/R to amplify a portion of 16S rDNA and rplJ/rplL ribosomal protein genes, respectively, of "Ca. L. solanacearum" (2,3). A 1,168-bp 16S rDNA fragment was detected in the DNA from 22 (81.5%) symptomatic plants and a 668-bp rplJ/rplL fragment was amplified from the DNA of 26 (96.3%) symptomatic and 5 (18.5%) asymptomatic plants, indicating the presence of liberibacter. No liberibacter was detected in the asymptomatic carrot plants with the primer pair OA2/OI2c. Amplicons from the DNA of four carrot root samples with each primer pair were cloned (pCR2.1-TOPO; Invitrogen, Carlsbad, CA) and three clones of each of the eight amplicons were sequenced (MCLAB, San Francisco, CA). BLAST analysis of the 16S rDNA consensus sequence from the carrot root tissues (GenBank Accession No. JN863097) showed 100% identity to those of "Ca. L. solanacearum" previously amplified from carrot (GU373048 and GU373049) and T. apicalis (GU477254 and GU477255) in Finland (2,3). The rplJ/rplL consensus sequence from the carrots (GenBank Accession No. JN863098) was 99% identical to the sequences of rplJ/rplL "Ca. L. solanacearum" ribosomal protein gene from carrots in Finland (GU373050 and GU373051). To our knowledge, this is the first report of "Ca. L. solanacearum" associated with carrot in Norway. This bacterial species has caused millions of dollars in losses to potato and several other solanaceous crops in North and Central America and New Zealand (1). This plant pathogen has also been reported from carrots and T. apicalis in Finland, where it has caused significant economic damage to carrot crops (2-4). References: (1) J. E. Munyaneza. Southwest. Entomol. 35:471, 2010. (2) J. E. Munyaneza et al. Plant Dis. 94:639, 2010. (3) J. E. Munyaneza et al. J. Econ. Entomol. 103:1060, 2010. (4) A. Nissinen et al. Entomol. Exp. Appl. 125:277, 2007.
Protein C and Protein S Activity in Sickle Cell Disease and Stroke (1997)

Stroke is a significant complication of sickle cell anemia in the pediatric population. The pathophysiology of stroke in sickle cell anemia remains unclear. Protein C and protein S activities were measured in children with sickle cell anemia and stroke, and compared to those with sickle cell anemia who were neurologically normal. Results showed significantly decreased levels of both protein C and protein S activities in children with sickle cell anemia who have had a stroke. This pilot study suggests that a possible coagulopathic state in children with sickle cell anemia may be associated with an increased risk for cerebrovascular disease. Further research in this area is indicated.
Control strategies for hybrid vehicles: optimal control (2003)

Control strategies for hybrid vehicles are algorithms that choose at each sampling time the power split between the engine and the motor. This paper presents global optimization algorithms based on the optimal control theory. The objective is to compute, in simulation, the minimum fuel consumption achievable with a given prototype on a given speed cycle. Results can be used as reference for the evaluation of real time control strategies and also for real-time control strategy synthesis.
Optimal oxygen saturations in preterm infants (2013)

Defining and maintaining optimal oxygen saturations in preterm infants remains a challenge for clinicians caring for preterm infants. However, ongoing investigative collaborations may soon provide guidance.
Tratamiento de la neoplasia intraepitelial de la Vulva (NIVU II-III) (2012)

The main goal of treatment of VIN II-III is to avoid progression to invasive vulvar cancer. Among the factors to consider for the treatment of VIN are the high recurrence rate, the patient’s age, and the size and location of the lesion. Nonetheless, it is of upmost importance to rule out invasion before treatment. The ideal method should safeguard vulvar anatomy and function while treating any symptoms. There are ablative, excisional as well as topical application methods. Excisional techniques have the advantage of obtaining tissue for pathology, taking into consideration that correct excisional depth is different in hairy and non-hairy areas.
Analysis of DNA changes in the LPL gene in patients with familial combined hyperlipidemia. (1994)

Familial combined hyperlipidemia (FCHL) is a common lipid disorder characterized by an increase in cholesterol and/or triglyceride levels in multiple individuals of the same family. Prior reports document a decreased activity of lipoprotein lipase (LPL) in FCHL, and studies of the role of LPL in the remodeling of nascent lipoproteins suggest that disturbances in LPL function could underlie FCHL. We studied the LPL gene in 31 unrelated individuals with FCHL. A total of 25 DNA changes (13 "silent" substitutions and 12 DNA changes resulting in amino acid substitutions) were detected in 16 patients. Three new exonic polymorphisms as well as a previously described Ser447-->stop and an Asp9-->Asn substitution were seen with similar frequency on control and FCHL chromosomes. Two novel DNA changes resulting in an Asp21-->Val and an His44-->Tyr substitution were seen in only two FCHL individuals. In vitro studies showed no effect of these mutations on LPL catalytic activity. LPL mutations impairing catalytic activity did not represent a significant factor leading to FCHL in this population. Variations in any portion of the coding region of the LPL gene affecting other functions besides catalysis are not a frequent cause of FCHL.
Potentiometric response of the calcium selective membrane electrode in the presence of surfactants (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotentiometric response of the calcium selective membrane electrode in the presence of surfactantsRamon A. LlenadoCite this: Anal. Chem. 1975, 47, 13, 2243–2249Publication Date (Print):November 1, 1975Publication History Published online1 May 2002Published inissue 1 November 1975https://pubs.acs.org/doi/10.1021/ac60363a013https://doi.org/10.1021/ac60363a013research-articleACS PublicationsRequest reuse permissionsArticle Views147Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Compact UWB Bandpass Filter With a Notched Band Using Radial Stub Loaded Resonator (2012)

In this letter, a novel compact ultra-wideband (UWB) microstrip bandpass filter (BPF) with a notched band is presented by using the proposed radial stub loaded resonator (RSLR). The RSLR, on the one hand, is able to control two tunable transmission zeros separately and on the other hand, has the ability to provide a notched band. In addition, the vertical dimension of the UWB BPF can be significantly reduced by using RSLR, as compared with the UWB BPF based on the conventional stub-loaded resonator (SISLR). For validation, two UWB BPFs, one without the notched band and the other with a notched band at 8.0 GHz for rejecting satellite-communication signal, are developed and fabricated. Measured results show two fabricated filters have the merits of low insertion losses, sharp rejections and flat group delays. Moreover, two filters exhibit the simple topologies and compact sizes.
Kinetics of <i>myo</i>-inositol loading in women of reproductive age (2003)

Myo-inositol enters the bloodstream quickly after oral ingestion and a small amount of myo-inositol is converted to scyllo-inositol. The synthesis of glucose from myo-inositol could not be detected by serum measurements. These data can be used in further research into the association between myo-inositol and neural tube defects.
Study on the Control and Fabrication of Thermal Fatigue Crack for Reliability Enhancement of NDT in Reactor Coolant System (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Genome-Wide Expression Analysis in<i>Drosophila</i>Reveals Genes Controlling Circadian Behavior (2002)

In Drosophila, a number of key processes such as emergence from the pupal case, locomotor activity, feeding, olfaction, and aspects of mating behavior are under circadian regulation. Although we have a basic understanding of how the molecular oscillations take place, a clear link between gene regulation and downstream biological processes is still missing. To identify clock-controlled output genes, we have used an oligonucleotide-based high-density array that interrogates gene expression changes on a whole genome level. We found genes regulating various physiological processes to be under circadian transcriptional regulation, ranging from protein stability and degradation, signal transduction, heme metabolism, detoxification, and immunity. By comparing rhythmically expressed genes in the fly head and body, we found that the clock has adapted its output functions to the needs of each particular tissue, implying that tissue-specific regulation is superimposed on clock control of gene expression. Finally, taking full advantage of the fly as a model system, we have identified and characterized a cycling potassium channel protein as a key step in linking the transcriptional feedback loop to rhythmic locomotor behavior.
Indirect Programming of Floating-Gate Transistors (2005)

Floating-gate transistors are useful for precisely programming a large array of current sources. Present floating-gate programming techniques require disconnection of the transistor from the rest of its circuit to be programmed. We present a new method of programming floating-gate transistors indirectly that does not require this disconnection. Two transistors share a floating gate allowing one to exist directly in a circuit while the other is reserved for programming. Since the transistor does not need to be disconnected from the circuit to program it, the switch count is reduced, resulting in fewer parasitics and better overall performance.
Aggregation Behavior of Giant Amphiphiles Prepared by Cofactor Reconstitution (2006)

We report on biohybrid surfactants, termed "giant amphiphiles", in which a protein or an enzyme acts as the polar head group and a synthetic polymer as the apolar tail. It is demonstrated that the modification of horseradish peroxidase (HRP) and myoglobin (Mb) with an apolar polymer chain through the cofactor reconstitution method yields giant amphiphiles that form spherical aggregates (vesicles) in aqueous solution. Both HRP and Mb retain their original functionality when modified with a single polystyrene chain, but reconstitution has an effect on their activities. In the case of HRP the enzymatic activity decreases and for Mb the stability of the dioxygen myoglobin (oxy-Mb) complex is reduced, which is probably the result of a disturbed binding of the heme in the apo-protein or a reduced access of the substrate to the active site of the enzyme or protein.
Cobalt(III) bipyridyl-branched polyoxazoline complex as a thermally and redox reversible hydrogel (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCobalt(III) bipyridyl-branched polyoxazoline complex as a thermally and redox reversible hydrogelYoshiki Chujo, Kazuki Sada, and Takeo SaegusaCite this: Macromolecules 1993, 26, 24, 6320–6323Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/ma00076a002https://doi.org/10.1021/ma00076a002research-articleACS PublicationsRequest reuse permissionsArticle Views677Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A clinical study of the outcomes and complications associated with maxillary sinus augmentation. (2006)

In the present study sinus membrane perforation was not shown to be a significant factor in the rate of implant complications. However, the combination of smoking and onlay bone grafting could significantly increase the rate of postoperative infection following sinus grafting.
Continuous Integration (2011)

The practice of continuous integration (CI) has the ability to transform software development from a set of manual processes to a logical series of reproducible, automated processes. At the heart of continuous integration is the CI server, which is the fundamental tool and technology that initiates, performs, coordinates, and reports on the CI phases. This chapter introduces you to CI server alternatives and describes their basic product offerings.KeywordsSource CodeUnit TestTarget EnvironmentCode ChangeCode QualityThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Ultraviolet‐Assisted Direct‐Write Fabrication of Carbon Nanotube/Polymer Nanocomposite Microcoils (2009)

The UV-assisted direct-write fabrication of microcoils is shown using a UV-photocurable carbon nanotube nanocomposite ink. The method employs the robotically controlled microextrusion of a filament combined with a UV exposure that follows the extrusion point. Upon curing, the increased rigidity of the extruded filament enables the creation of complex multi-directional shapes.
Adaptive Garbage Collection Mechanism for N-log Block Flash Memory Storage Systems (2006)

Write operations in flash memory should be preceded by erase operations, which take an order of magnitude longer than writes. Therefore an update of a single byte causes an erasing of the whole block as well as restoration of a large amount of data. In order to avoid erasing during every update, non-in-place update schemes have been used. Obsolete data are later recycled by garbage collection. In this paper, we study a new garbage collection algorithm for the N-log block flash memory storage system, to reduce the recycling cost such as the number of erase operations and the number of data copies. The proposed scheme selects the victims according to the age and utilization. And selection algorithm changes dynamically with the I/O workload. Experimental results show that the proposed scheme reduces the extra erase operations greatly.
Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals (2009)

Gray matter pathology is increasingly recognized as an important feature of multiple sclerosis (MS), but the nature of the immune response that targets the gray matter is poorly understood. Starting with a proteomics approach, we identified contactin-2/transiently expressed axonal glycoprotein 1 (TAG-1) as a candidate autoantigen recognized by both autoantibodies and T helper (Th) 1/Th17 T cells in MS patients. Contactin-2 and its rat homologue, TAG-1, are expressed by various neuronal populations and sequestered in the juxtaparanodal domain of myelinated axons both at the axonal and myelin sides. The pathogenic significance of these autoimmune responses was then explored in experimental autoimmune encephalitis models in the rat. Adoptive transfer of TAG-1-specific T cells induced encephalitis characterized by a preferential inflammation of gray matter of the spinal cord and cortex. Cotransfer of TAG-1-specific T cells with a myelin oligodendrocyte glycoprotein-specific mAb generated focal perivascular demyelinating lesions in the cortex and extensive demyelination in spinal cord gray and white matter. This study identifies contactin-2 as an autoantigen targeted by T cells and autoantibodies in MS. Our findings suggest that a contactin-2-specific T-cell response contributes to the development of gray matter pathology.
An operational semantics and type safety prooffor multiple inheritance in C++ (2006)

We present an operational semantics and type safety proof for multiple inheritance in C++. The semantics models the behaviour of method calls, field accesses, and two forms of casts in C++ class hierarchies exactly, and the type safety proof was formalized and machine-checked in Isabelle/HOL. Our semantics enables one, for the first time, to understand the behaviour of operations on C++ class hierarchies without referring to implementation-level artifacts such as virtual function tables. Moreover, it can - as the semantics is executable - act as a reference for compilers, and it can form the basis for more advanced correctness proofs of, e.g., automated program transformations. The paper presents the semantics and type safety proof, and a discussion of the many subtleties that we encountered in modeling the intricate multiple inheritance model of C++.
Application Framework for Efficient Development of Sensor as a Service for Home Network System (2011)

The sensor as a service is an emerging application of the services computing. However, how to implement such sensor services efficiently and reliably is an open issue. This paper presents an application framework, called Sensor Service Framework (SSF), that supports developers to build and deploy sensor services in the home network system (HNS). The SSF prescribes device-neutral features and APIs for the sensor devices to be deployed as Web services. Writing a small amount of code with the SSF, the developer can easily deploy any sensor device as a service in the HNS. The sensor service can provide a standardized access to heterogeneous sensor devices, as well as a context management service with user-defined conditions. We then present a sensor mashup platform (SMuP), which allows the dynamic composition of the existing sensor services. To support non-expert developers, we also implemented a GUI front-end, called Sensor Service Binder (SSB). The proposed technologies are implemented and evaluated in an actual HNS to demonstlate practical feasibility.