gebhart/patrepeval huggingface dataset:
Metabolism of methoxymorpholino‐doxorubicin in rat, dog and monkey liver microsomes: comparison with human microsomes (2001)

The morpholino anthracycline, methoxymorpholino-doxorubicin (MMDx) is a novel anticancer agent. The metabolism of this highly lipophilic doxorubicin analogue is not fully elucidated. MMDx is metabolically activated in vivo, resulting in an 80-fold increase in potency over the parent drug. In this study, MMDx in vitro metabolism was compared in rat, dog, monkey and human liver microsomes. When microsomal fractions were incubated with MMDx, 6-8 metabolites were formed depending on the species and on the substrate concentrations. Among these eight metabolites, three comigrated with authentic standards, namely MMDx-ol, PNU156686 and PNU159682, and the five others are in the process of being characterized. Quantitatively, monkey and human metabolize MMDx with a higher rate than rat and dog. Qualitatively, MMDx metabolic profile in dog microsomes was different from the three other species. MMDx-ol was predominant in dog and only minor in other species. In conclusion, MMDx metabolism was species-different. Rat and monkey liver microsomes may be used as models to study MMDx metabolism in humans. Dog liver microsomes may be a good model for studying the formation of MMDx-ol.
Investigation of the performance of a controlled router for the CEBus (home automation) (1992)

A study of the delay and throughput of the consumer electronics bus (CEBus) with two media, power line (PL) and twisted pair (TP), interconnected through a controlled router with three priorities (HIGH, STANDARD, and DEFERRED) is discussed. The controlled router aims to provide fair channel access opportunities for intranetwork traffic for messages of all priorities. It reduces excessive channel access by internetwork traffic through the router and maintains the delay of intranetwork traffic at reasonable levels. The results of the simulation experiments are presented. The message delay of HIGH for internetwork traffic on the PL is of a larger value than that of HIGH and STANDARD for intranetwork traffic at light load and is smaller than that of the STANDARD and DEFERRED at heavy load. Moreover, the intranetwork message throughputs and delays of STANDARD and DEFERRED have improved greatly, in comparison to a traditional uncontrolled router, at only a small cost in internetwork HIGH performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Video Stitch Algorithm Based on Dynamic Foreground Extraction (2009)

A new video stitch algorithm based on dynamic foreground extraction is proposed in this paper. The algorithm is found on static image mosaic. To solve the problem caused by the moving objects in the videos, the background images are extracted. Using the featured-based method to get the transformation matrix between the background images, a wide background video is stitched up. This method greatly improves the efficiency of the algorithm. Besides, the moving foreground objects are extracted and the comparability between objects in the overlap area of different videos is computed to decide whether they are the same object and which to be reserved in the wide background video. As a result, the ghost is removed. Experimental results show that it is a highly-matched and robust video stitch algorithm, and can basically achieve real-time stitch.
Antigenic and immunogenic properties of recombinants from Salmonella typhimurium and Salmonella minnesota rough mutants expressing in their lipopolysaccharide a genus-specific chlamydial epitope (1987)

Rough mutants from Salmonella typhimurium and Salmonella minnesota were transformed with a plasmid containing a 6.5-kilobase insert of DNA from Chlamydia trachomatis assumed to encode a glycosyltransferase. Transformation resulted in the expression of a genus-specific chlamydial epitope on the lipopolysaccharide (LPS) of the recombinant strains. Proteinase K-digested whole-cell lysates of the recombinants and of controls were subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by silver staining or Western blot analysis. Two LPS populations were detected in the recombinants, the parent LPS and a faster-migrating component. The latter stained with monoclonal antibody against the genus-specific chlamydial epitope and was not seen in the controls. LPS was extracted and purified from recombinants of S. minnesota R595 and R4 and characterized by the passive hemolysis and passive hemolysis inhibition assays and by hydrolysis kinetics. Different antigenic determinants could be distinguished from each other by the passive hemolysis inhibition test with monospecific antigen-antibody reactions. Rabbits were immunized with heat-killed recombinant bacteria to study the immunogenic properties of the recombinants. In all animals, antibodies were raised against the parent core specificity and against the chlamydia-specific epitope. The data show that the recombinant bacteria are useful as immunogens to prepare polyclonal antisera against chlamydiae and that LPS isolated from them exhibits the same antigenic determinants as chlamydial LPS and may thus be used as a substitute for chlamydial LPS in serological assays.
Sanctions Block Malayan Tin and Rubber Sales (1936)

Other| January 01 1936 Sanctions Block Malayan Tin and Rubber Sales H. M. H. M. Search for other works by this author on: This Site PubMed Google Scholar Far Eastern Survey (1936) 5 (1): 7. https://doi.org/10.2307/3021328 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation H. M.; Sanctions Block Malayan Tin and Rubber Sales. Far Eastern Survey 1 January 1936; 5 (1): 7. doi: https://doi.org/10.2307/3021328 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAsian Survey Search This content is only available via PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
Role of electrophysiologic evaluation in patients with ventricular arrhythmias. (1996)

The decision to perform electrophysiologic testing in patients with ventricular arrhythmia should be based on the presence, if any, of underlying heart disease and the clinical type of ventricular arrhythmia. Clinical presentations range from asymptomatic premature ventricular complexes identified on routine surface ECG to out-of-hospital cardiac arrest. Ventricular arrhythmias range from benign monomorphic ventricular ectopy to polymorphic VT and ventricular fibrillation. The goal in evaluating patients with ventricular arrhythmia is to identify those at high risk of suffering a life-terminating arrhythmic event. Risk stratification should be based on history, physical examination, clinical data and the likelihood that anti-arrhythmic therapy will prevent symptoms and more importantly, prolong life. Noninvasive evaluation with routine surface ECG, Holter monitoring, signal-averaged ECG and echocardiography are valuable tools in the risk stratification process. However, electrophysiologic testing in most forms of ventricular tachyarrhythmia is the optimal means of diagnosing, risk stratifying and managing potentially life-threatening ventricular arrhythmias.
Power analysis for sequential circuits at logic level (1996)

This paper introduces a novel technique to determine the transition probabilities of internal signals for sequential circuits. We account for temporal correlations of primary inputs and internal signals, sequential correlations, and spatial correlations of internal signals. For this purpose, we exploit and combine concepts of unrolling reconvergence analysis, decomposing packers of temporally correlated variables, and Markov chains. Experimental results demonstrate the high accuracy and efficiency of our technique.
Digital subscriber line technology facilitates a graceful transition from copper to fiber (1991)

The loop environment and the techniques that historically have been used for providing transmission treatment are reviewed. The digital subscriber line (DSL), which applies adaptive filtering to yield significant performance and administrative advantages, is introduced. How this technology will evolve to complement the emerging fiber-based network, providing timely, ubiquitous wire pair transmission capabilities at basic rate, primary rate, and above is examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Simultaneous imaging of artery-wall strain and blood flow by high frame rate acquisition of RF signals (2008)

Mechanical properties of the arterial walls are significantly altered by atherosclerosis, and various studies have been recently conducted to measure the regional elastic properties (radial strain) of the arterial wall. We have developed a phase-sensitive correlation-based method, namely, the phased-tracking method, to measure the regional radial strain. On the other hand, the measurement of blood flow is an important practical routine in the diagnosis of atherosclerosis. It would be useful if the regional strain of the arterial wall as well as blood flow could be assessed simultaneously. Such measurement would require a high frame rate of several kilohertz. In this study, acquisition of ultrasonic RF echoes at a high frame rate (about 3500 Hz) was achieved using parallel beamforming in which plane waves were transmitted only 3 times and receive beamforming created 24 beams for each transmit beam. The accuracy in measurement of the minute radial strain was evaluated by a basic experiment using a cylindrical phantom. The error of the measured strain from the theoretical strain profile and its standard deviation were 4.8% and 9.5%, respectively. Furthermore, the radial strain of a carotid arterial wall and blood flow were simultaneously imaged in vivo.
A Theoretical and Experimental Analysis of Radiofrequency Ablation with a Multielectrode, Phased, Duty-Cycled System (2010)

Both the in vitro and computational model results demonstrate that lesion depth decreases consistently as the bipolar-to-unipolar ratio increases-suggesting a clinical application to potentially control lesion depth with higher fidelity than is currently available. The effect of variable design parameters and clinical conditions on RF ablation can now be expeditiously studied with this validated model.
Data analysis: a Bayesian tutorial (1997)

1. The Basics 2. Parameter Estimation I 3. Parameter Estimation II 4. Model Selection 5. Assigning Probabilities 6. Non-parametric Estimation 7. Experimental Design 8. Least-Squares Extensions 9. Nested Sampling 10. Quantification Appendices Bibliography
A prediction strategy for efficient entropy coding of VQ addresses (2002)

A novel predictive coding scheme is presented where the residual correlations between VQ contiguous blocks are exploited by a neural predictor. A further compression is then achieved via a dynamic codebook reordering and a more efficient Huffman encoding of vector addresses.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Elliptical pore regularisation of the inverse problem for microstructured optical fibre fabrication (2015)

A mathematical model is presented describing the deformation, under the combined effects of surface tension and draw tension, of an array of channels in the drawing of a broad class of slender viscous fibres. The process is relevant to the fabrication of microstructured optical fibres, also known as MOFs or holey fibres, where the pattern of channels in the fibre plays a crucial role in guiding light along it. Our model makes use of two asymptotic approximations, that the fibre is slender and that the cross-section of the fibre is a circular disc with well-separated elliptical channels that are not too close to the outer boundary. The latter assumption allows us to make use of a suitably generalised ‘elliptical pore model (EPM)’ introduced previously by one of the authors (Crowdy, J. Fluid Mech. , vol. 501, 2004, pp. 251–277) to quantify the axial variation of the geometry during a steady-state draw. The accuracy of the elliptical pore model as an approximation is tested by comparison with full numerical simulations. Our model provides a fast and accurate reduction of the full free-boundary problem to a coupled system of nonlinear ordinary differential equations. More significantly, it also allows a regularisation of an important ill-posed inverse problem in MOF fabrication: how to find the initial preform geometry and the experimental parameters required to draw MOFs with desired cross-plane geometries.
Effects of carbamazepine on pituitary-adrenal function in healthy volunteers. (1992)

Carbamazepine (CBZ) is a widely used therapeutic agent in seizure, pain, and mood disorders. Although CBZ has been shown to inhibit hypothalamic CRH secretion in vitro, limited data suggest that systemic CBZ induces pituitary-adrenal activation. Few data are available to reconcile these effects or clarify their mechanism(s), particularly in healthy human subjects. We report here a study of basal ACTH and cortisol secretion and their responses to ovine CRH administration in nine healthy volunteers, studied both during repeated (2-3 weeks) administration of CBZ and while medication free. CBZ significantly increased mean 24-h urinary free cortisol (mean +/- SE, 197 +/- 17 vs. 137 +/- 24 nmol/day; P less than 0.02) and evening basal total plasma cortisol (113 +/- 17 vs. 83 +/- 14 nmol/L; P less than 0.05) as well as cortisol-binding globulin-binding capacity (497 +/- 36 vs. 433 +/- 28 nmol/L; P less than 0.01). Despite the CBZ-induced hypercortisolism, plasma ACTH responses to CRH during CBZ treatment remained robust, rather than being suppressed by basal hypercortisolism. In fact, during CBZ treatment, we noted a positive correlation between the increase in basal plasma cortisol and the increase in the plasma ACTH response to CRH (r = 0.65; P less than 0.05). We also observed a reduction in cortisol-binding globulin-binding capacity after CRH administration (315 +/- 25 vs. 433 +/- 28 nmol/L; P less than 0.001), which was accentuated by CBZ treatment (342 +/- 19 vs. 497 +/- 36 nmol/L; P less than 0.001; magnitude of fall, -155 +/- 22 nmol/L on CBZ vs. -118 +/- 11 nmol/L off CBZ; P less than 0.05). We conclude that CBZ increases plasma cortisol secretion in healthy volunteers independent of its effect on plasma cortisol-binding capacity. This pituitary-adrenal activation seems to reflect a pituitary, rather than a hypothalamic, effect of CBZ. Hence, despite CBZ-induced hypercortisolism, the ACTH response to CRH remained robust in direct proportion to the CBZ-induced rise in basal plasma cortisol. Thus, we propose that the increased cortisol secretion observed during CBZ treatment reflects a relative inefficacy of glucocorticoid negative feedback at the pituitary. This pituitary-driven increase in cortisol secretion combined with the expected reduction in centrally directed CRH secretion could contribute to the anticonvulsant properties of CBZ.
RNAi-mediated silencing of TEL/AML1 reveals a heat-shock protein– and survivin-dependent mechanism for survival (2006)

The TEL/AML1 fusion gene results from the most frequent t(12;21)(p13;q22) translocation in childhood acute lymphoblastic leukemia (ALL). Its contribution to transformation is largely unknown, in particular with respect to survival and apoptosis. We therefore silenced TEL/AML1 expression in leukemic REH cells by RNA inhibition, which eventually led to programmed cell death. Microarray and 2D gel electrophoresis data demonstrated a differential regulation of heat-shock proteins (HSPs), among them HSP90, as well as of its client, survivin. Consistent with these findings, ectopic expression of TEL/AML1 in Ba/F3 cells increased protein levels of HSP90 and survivin and conferred resistance to apoptotic stimuli. Our data suggest that TEL/AML1 not only contributes to leukemogenesis by affecting an antiapoptotic network but also seems to be indispensable for maintaining the malignant phenotype. The functional relationship between TEL/AML1, HSP90, and survivin provides the rational for targeted therapy, be it the fusion gene or the latter 2 proteins.
Transforming Growth Factor-β Isoform Expression in the Perisutural Tissues of Craniosynostotic Rabbits (2004)

Findings from this study suggest that an overexpression of Tgf-beta2, either in isolation or in association with an underexpression of Tgf-beta1 and Tgf-beta3, may be related to premature suture fusion (craniosynostosis) in this pathological rabbit model. These abnormal expression patterns may be involved in premature suture fusion either through increased cell proliferation, decreased apoptosis of the osteoblasts or both at the osteogenic fronts.
Efficacy of Gabapentin in Migraine Prophylaxis (2001)

Gabapentin is an effective prophylactic agent for patients with migraine. In addition, gabapentin appears generally well tolerated with mild to moderate somnolence and dizziness.
Immunological studies on the Epstein--Barr virus encoded alkaline deoxyribonuclease found in virus-producing lymphoblastoid cells (1991)

Antisera were raised against a purified recombinant form of the Epstein-Barr virus (EBV) alkaline deoxyribonuclease (DNase) expressed in Escherichia coli. These sera were shown to be reactive with lymphoblastoid cells expressing EBV antigens (B95-8, P3HR-1 and Raji). Immunostaining studies of cells expressing EBV antigens revealed that the DNase was a component of the restricted early antigen complex of EBV. Western blot analysis of these chemically induced cells revealed that the polypeptide associated with the EBV DNase has an Mr of approximately 55,000, slightly greater than that of the recombinant form, suggesting that the protein undergoes some form of posttranslational modification during virus replication. The DNase enzymic activities observed in B95-8, P3HR-1 and Raji cells following chemical induction were neutralized using the specific antiserum. A detailed examination of protein extracts from the nude mouse-passaged nasopharyngeal carcinoma cell line C-15 failed to detect any antigenic or biochemical evidence for the presence of the DNase. Immunostaining of biopsies of oral 'hairy' leukoplakia with the antisera against EBV DNase revealed high level expression in the more differentiated spinous layers of the epithelium, a pattern of reactivity identical to that observed for other lytic cycle antigens.
A glucose biosensor based on electrodeposited biocomposites of gold nanoparticles and glucose oxidase enzyme. (2001)

Electrodeposition was used for the codeposition of glucose oxidase enzyme and a gold nanoparticle-silicate network onto an indium tin oxide (ITO) glass electrode. This co-entrapment of glucose oxidase enzyme in a gold nanoparticle-silicate network imparts biocatalytic activity to the film. The gold nanoparticles in the network catalyse the oxidation and reduction of H2O2, the by-product of the enzymatic reaction. The low operating potential of the sensor eliminates the interference from common interferents, such as acetaminophen, ascorbic acid, dopamine, etc.
Trifluoroperacetic acid. Oxidation of aromatic rings (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTrifluoroperacetic acid. Oxidation of aromatic ringsR. Liotta and W. S. HoffCite this: J. Org. Chem. 1980, 45, 14, 2887–2890Publication Date (Print):July 1, 1980Publication History Published online1 May 2002Published inissue 1 July 1980https://pubs.acs.org/doi/10.1021/jo01302a026https://doi.org/10.1021/jo01302a026research-articleACS PublicationsRequest reuse permissionsArticle Views1377Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pharmacologic effects and abuse liability of bretazenil, diazepam, and alprazolam in humans (1994)

Results from the study supported the view that bretazenil may have a partial agonist pharmacologic profile. Scores on subjective effects scales considered important for abuse liability assessment suggest a lower abuse liability of bretazenil than diazepam and alprazolam.
All-optical 2R regeneration based on integrated asymmetric Mach-Zehnder interferometer incorporating MMI-SOA (2002)

2R regeneration is proposed with an integrated Mach-Zehnder interferometer containing a monomodal semiconductor optical amplifier (SOA) and an SOA with a 1×1 multimode interference (MMI) coupler- SOA in the arms. Simulations and measurement of the static transfer function show a digital shape with a high extinction ratio improvement.
Fabrication of ceramic membrane tubes for direct conversion of natural gas (1992)

Several perovskite-type oxides that contain transition metals on the B-site show mixed (electronic/ionic) conductivity. These mixed conducting oxides are promising materials for oxygen permeating membranes that can operate without the need of electrodes or external electrical circuitry. SrCo{sub 0.8}Fe{sub 0.2}O{sub x} perovskite is known to exhibit very high oxygen permeabilities and one could use this material for producing value added products by direct conversion of methane, the most abundant component of natural gas. This paper deals with the processing and fabrication by plastic extrusion of long lengths ({approx}30 cm) of hollow SrCo{sub 0.8}Fe{sub 0.2}O{sub x} ceramic tubes. These tubes are characterized by scanning electron microscopy, X-ray diffraction (XRD) and their thermodynamic stability is evaluated using room temperature XRD on samples equilibrated at high temperatures in different gas environment.
Plasmonic modulator with >170 GHz bandwidth demonstrated at 100 GBd NRZ (2017)

We demonstrate a plasmonic Mach-Zehnder (MZ) modulator with a flat frequency response exceeding 170 GHz. The modulator comprises two phase modulators exploiting the Pockels effect of an organic electro-optic material in plasmonic slot waveguides. We further show modulation at 100 GBd NRZ and 60 GBd PAM-4. The electrical drive signals were generated using a 100 GSa/s digital to analog converter (DAC). The high-speed and small-scale devices are relevant for next-generation optical interconnects.
A New Fluorescence Sensor for Quantification of Atmospheric Humidity (1989)

A new fiber‐optic sensor (optrode) for humidity has been developed. The sensor utilizes a fluorescent dye entrapped within a perfluorinated ionomer matrix. The fluorescence intensity increases strongly and linearly with increasing watervapor partial pressure even though the lifetime of fluorescence is simultaneously lowered. The response time of the optrode is approximately 1s and the presence of has no detectable effect on the determination of humidity. Apparently, the immobilized fluorescent dye, rhodamine 6G, associates with water to form a complex with a higher absorptivity. The dependence of fluorescence lifetime on emission wavelength revealed the coexistence of multiple excited states for the water‐dye system.