gebhart/patrepeval huggingface dataset:
Effects of intermittent hemodialysis on buprenorphine and norbuprenorphine plasma concentrations in chronic pain patients treated with transdermal buprenorphine (2006)

The present study was designed to study the impact of intermittent hemodialysis on the disposition of the partial agonist buprenorphine and its metabolite norbuprenorphine during therapy with transdermal buprenorphine in chronic pain patients with end-stage kidney disease. Ten patients (mean age 63 years) who had received transdermal buprenorphine for at least 1 week, were asked to provide blood samples immediately before and after hemodialysis. Blood samples were analysed for buprenorphine and its metabolite norbuprenorphine. The median buprenorphine plasma concentrations were found to be 0.16 ng/ml before and 0.23 ng/ml after hemodialysis. A significant correlation between plasma levels and administered doses was observed (Spearman R=0.74; P<0.05). In three patients norbuprenorphine plasma levels were detected. No differences in pain relief before and after hemodialysis were observed. This investigation shows no elevated buprenorphine and norbuprenorphine plasma levels in patients with renal insufficiency receiving transdermal buprenorphine up to 70 microg/h. Furthermore, hemodialysis did not affect buprenorphine plasma levels, leading to stable analgesic effects during the therapy.
A common site within factor H SCR 7 responsible for binding heparin, C‐reactive protein and streptococcal M protein (2003)

The complement inhibitor factor H (fH) interacts via its seventh short consensus repeat (SCR) domain with multiple ligands including heparin, streptococcal M protein and C-reactive protein (CRP). The aim of this study was to localize the residues in SCR 7 required for these interactions. We initially built a homology model of fH SCR 6-7 using the averaged NMR structures of fH SCR 15-16 and vaccinia control protein SCR 3-4 as templates. Electrostatic potentials of the model's surface demonstrated a co-localization of three clusters of positively charged residues on SCR 7, labeled site A (R369 and K370), site B (R386 and K387) and site C (K392). These residues, localized to the linker region preceding SCR 7 and to the end of a "hypervariable loop" in SCR 7, were systematically replaced with uncharged alanine residues in an fH construct containing SCR 1-7. The resulting proteins were expressed in the methylotrophic yeast, Pichia pastoris. By ELISA analysis we demonstrated: first, that substituting site A inhibited heparin and CRP binding; secondly, that substituting site B inhibited binding to heparin, CRP and M protein; and thirdly, that substituting site C clearly inhibited only heparin binding.
A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis (2006)

This is the first study showing that diet, specifically a KD, alters the progression of the clinical and biological manifestations of the G93A SOD1 transgenic mouse model of ALS. These effects may be due to the ability of ketone bodies to promote ATP synthesis and bypass inhibition of complex I in the mitochondrial respiratory chain.
Genetic Variation in the Progesterone Receptor Gene and Ovarian Cancer Risk (2005)

Evidence suggests a role for progesterone in ovarian cancer development. Progesterone exerts its effect on target cells by interacting with its receptor. Thus, genetic variations that may cause alterations in the biologic functions of the progesterone receptor can potentially contribute to individual susceptibility to ovarian cancer. Using a population-based, case-control study, the authors genotyped four polymorphisms in the progesterone receptor gene (+44C/T, +331G/A, G393G, V660L) and inferred haplotypes in 987 ovarian cancer cases and 1,034 controls living in New Hampshire and eastern Massachusetts (May 1992-November 2002). Odds ratios and 95% confidence intervals were calculated to evaluate associations with ovarian cancer. No associations were observed between the +44C/T, +331G/A, and G393G polymorphisms and ovarian cancer. However, an inverse association was observed between the V660L variant and ovarian cancer (odds ratio = 0.70, 95% confidence interval: 0.57, 0.85). Associations remained after adjustment for potential confounders. Five haplotypes occurred with greater than 5% frequency, and the haplotype carrying the V660L variant had a significant association with ovarian cancer (odds ratio = 0.76, 95% confidence interval: 0.62, 0.92). Associations were similar after stratifying by ovarian cancer histologies and risk factors.
Augmented expression of peroxiredoxin VI in rat lung and kidney after birth implies an antioxidative role (2001)

A family of proteins with thioredoxin (TRx)-dependent peroxidase activity, referred to as peroxiredoxins (PRx), has been identified in many species. The sixth member of this family, PRxVI, contains only one conserved cysteine residue, while other members contain additional cysteines. We have isolated a cDNA for rat PRxVI and constructed a large scale baculovirus system to produce the recombinant protein. The protein was purified by a simple two-step procedure utilizing ion-exchange and gel-filtration chromatography. The purified PRxVI exhibited a low level of glutathione-dependent peroxidase but not TRx-dependent activity. PRxVI expression was the highest in lung, followed by brain, kidney, heart, testis, etc. as judged by Northern and Western blot analyses using a rabbit antibody to the purified PRxVI. Immunohistochemical analyses showed strong staining in the epithelium of the bronchus and bronchioles in lung and in the epithelial cells of kidney tubules. In addition, Sertoli cells in testis and islet of Langerhans cells in pancreas were strongly stained. The developmental changes of PRxVI expression in lung and kidney were low in the prenatal stage but induced postnatally. Moreover, intraperitoneal administration of chloroform induced PRxVI mRNA in kidney. When the distribution and the induced expression of PRxVI under conditions of oxidative stress are considered, a physiological role of it as an antioxidative enzyme is indicated.
Construction Contract Staffing Needs (1980)

This paper presents some of the current practices within a context of change, because the dynamic environment that is highway construction demands a constant reappraisal of present conditions. The first step in any construction manpower management system is planning, or predicting manpower needs. The planning systems that have recently been developed in Michigan, Louisiana, Arkansas and Washington are presented. Although each of these states has adopted a slightly different approach, as a group they probably offer the best example of what can be done to improve current planning practices. The key elements examined from these planning systems include: (1)Classification of projects; (2)definition of contractor activities; (3)development of work measurement units; (4)definition of agency construction engineering activities; and (5)conversion to man-hours required. Productivity standards are also presented. The appropriate use of these standards will permit both long-range planning at the district level and short-range planning at the project level.
Simplified SVPWM based hybrid PWM for induction motor drives for the reduction of torque ripples (2011)

A voltage source inverter-fed induction motor produces a pulsating torque due the application of no sinusoidal voltages. Torque pulsation is strongly influenced by switching fashion employed. This paper presents the simplified hybrid pulse width modulating technique for the reduction of torque ripples in an induction mo tor. In conventional space vector pulse width modulating (CSVPWM) technique (0127-7210) the zero states are divided equally and give rise to continuous modulating technique. The hybrid PWM is a combination of both continuous and discontinuous PWM techniques. To modulate the required voltage vector calculation of magnitude and angle are required which is complex. In this paper a simplified algorithm based on the concept of imaginary switching times is implemented. To validate this method simulation has been carried out in MATLAB 7.8 on v/f control of induction motor.
Reduction of contradictory partial occlusion in mixed reality by using characteristics of transparency perception (2012)

One of the challenges in mixed reality (MR) applications is handling contradictory occlusions between real and virtual objects. The previous studies have tried to solve the occlusion problem by extracting the foreground region from the real image. However, real-time occlusion handling is still difficult since it takes too much computational cost to precisely segment foreground regions in a complex scene. In this study, therefore, we proposed an alternative solution to the occlusion problem that does not require precise foreground-background segmentation. In our method, a virtual object is blended with a real scene so that the virtual object can be perceived as being behind the foreground region. For this purpose, we first investigated characteristics of human transparency perception in a psychophysical experiment. Then we made a blending algorithm applicable to real scenes based on the results of the experiment.
Configuration Control of a Mobile Dexterous Robot: Real-Time Implementation and Experimentation (1997)

This article describes the design and implementation of a real- time control system with multiple modes of operation for a mobile, dexterous manipulator. The manipulator under study is a kinematically redundant seven-degree-of-freedom arm from Robotics Research Corporation, mounted on a one-degree-of- freedom motorized platform. The manipulator-plus-platform system has two degrees-of-redundancy for the basic task of end-effector placement and orientation. The redundancy reso lution is achieved by accomplishing two additional tasks using the configuration-control technique. The system allows a choice of arm-angle control or collision avoidance for the seventh task, and elbow-angle control or platform placement for the eighth task. In addition, joint-limit avoidance tasks are auto matically invoked when any of the manipulator joints approach their limits. The system is robust to singularities, and the user is capable of assigning weighting factors to end-effector mo tion, joint-limit avoidance, and redundancy resolution tasks. The motion-control algorithms are executed at 1.1 ms on two MC68040 processors in a VME-bus environment running the VxWorks real-time operating system. The article describes the hardware and software components of the manipulator- control system. Experimental results on real-time control of the Robotics Research arm are also presented.
Douglas C. Allen Lecture (2009)

Presented on November 2, 2009 at 6PM in the Reinsch-Pierce Family Auditorium on the Georgia Tech campus.
Divorced Eutectic Precipitation in Isothermally Solidified Spinel-YAG Composite with Off-Eutectic Composition (1998)

Microstructure of spinel-YAG eutectic composite with spinel-rich composition was studied. It was identified that the nano-sized intergranular precipitate with YAG composition could precipitate during isothermal solidification of the composite containing intergranular eutectic melt formed in high temperature annealing process, accompanied with specific acicular primary growth of spinel phase. Furthermore, a set of orientation relationships at the interfaces between YAG and spinel phases in the solidified sample were revealed by TEM and confirmed by crystal structural analyses. The formation process of the solidified microstructure was investigated based on the principle of divorced eutectic precipitation. (orig.) 15 refs.
A single amino acid substitution in influenza hemagglutinin abrogates recognition by monoclonal antibody and a spectrum of subtype‐specific L3T4<sup>+</sup> T cell clones (1987)

A fine specificity analysis of influenza hemagglutinin-specific IAk-restricted T cell clones using natural virus variants of the H3N2 subtype, monoclonal antibody-selected variants and a synthetic peptide corresponding to a variable region of the HA1 polypeptide has provided insight on the structural basis for T cell recognition. A glycine to arginine substitution at HA1 135 abrogates recognition by a panel of T cell clones which, according to their reactivity for natural virus variants, have different antigenic specificities: three clones recognize a synthetic peptide (HA1 residues 118-138) but fail to recognize the monoclonal antibody-selected mutant (Gly135/Arg). There is no correlation, however, between differences in T cell specificity for the natural virus variants and HA1 amino acid sequences in this region. Two further clones have a reduced proliferative response to mutant recognize a completely different spectrum of natural variants, and only one of these clones recognizes the synthetic peptide. We speculate that influenza hemagglutinin employs a common strategy during antigenic drift to evade antibody recognition and effective processing/presentation to subtype-specific T cell clones.
Bone resorption and turnover in health and disease. (1987)

Excessive bone loss is a common cause of disability and presents a major public health problem in western societies. The most common cause is age-related bone loss and osteoporosis, but other common diseases associated with increased bone resorption include malignant disease, primary hyperparathyroidism, and Paget's disease. Despite the frequency of these disorders and the suffering they cause, their pathophysiology still remains obscure. However, recent advances in techniques in bone cell biology are now providing new insights into the pathogenesis and treatment of diseases associated with increased bone resorption. These advances have been paralleled by improvements in techniques for non-invasive assessment of bone status in patients with the common metabolic bone diseases.
Acquiring Working Knowledge through Asynchronous Multimedia Conferencing (2000)

Asynchronous text-based communication has long been established as having value in supporting the collaborative sharing of knowledge. However, in cases where learners or practitioners are seeking to acquire skills applicable in real-world working contexts, this kind of technology proves to be insufficient. Asynchronous multimedia conferencing seems both suitable and sufficient for supporting such a process. This paper presents a Web-based
Studies on the Alkaloids of Menispermaceous Plants. CLXVI (1958)

dl-N, 4′-Dimethylisococlaurine (VI) is the phenolic by-product obtained on cleavage of isotetrandrine (I) with metallic lithium in liquid ammonia, with dioxane as a solvent. The racemic compound of (VI) was synthesized by the route of (IX)→(X)→(XI)→(XII)→(VI), obtained as a free base of m.p. 45° and a picrate of m.p. 138°. Infrared absorption spectra of the two showed them to have identical structure and the structure of (VI) was thus synthetically confirmed. Attempted reduction of 3, 4-dihydroisoquinoline compound (X) to (XII) in one step with palladium-carbon catalyst afforded a benzoyl compound (XIII) as a by-product and its structure was identified.
The effect of brain tumors on BOLD functional MR imaging activation in the adjacent motor cortex: implications for image-guided neurosurgery. (2000)

Notwithstanding the differences noted, the motor cortex was identified successfully in all patients. This was confirmed by intraoperative physiological identification of the motor cortex and a lack of postoperative neurologic deficit.
Profanation/Sanctification and the Past, Present and Future of Israel in the Book of Ezekiel (2003)

It is well known that the book of Ezekiel is replete with the vocabulary of holy and profane on the one hand, and contains several retellings of the history of Israel on the other hand. It is the purpose of this study to examine the relationship between these two aspects. It is argued that Israel’s past is characterized as a history of profanation of what pertains to God, its present exilic condition is depicted as a state of profanation, and its future is portrayed as a result of God’s sanctification. It is also noted that this understanding of Israel’s history reveals the ambivalent character of the (experience of) exile.
Airborne Relay-Based Regional Positioning System (2015)

Ground-based pseudolite systems have some limitations, such as low vertical accuracy, multipath effects and near-far problems. These problems are not significant in airborne-based pseudolite systems. However, the monitoring of pseudolite positions is required because of the mobility of the platforms on which the pseudolites are mounted, and this causes performance degradation. To address these pseudolite system limitations, we propose an airborne relay-based regional positioning system that consists of a master station, reference stations, airborne relays and a user. In the proposed system, navigation signals are generated from the reference stations located on the ground and are relayed via the airborne relays. Unlike in conventional airborne-based systems, the user in the proposed system sequentially estimates both the locations of airborne relays and his/her own position. Therefore, a delay due to monitoring does not occur, and the accuracy is not affected by the movement of airborne relays. We conducted several simulations to evaluate the performance of the proposed system. Based on the simulation results, we demonstrated that the proposed system guarantees a higher accuracy than airborne-based pseudolite systems, and it is feasible despite the existence of clock offsets among reference stations.
Mixed Phase Surface Consistent Deconvolution without Phase Unwrapping (2001)

3 signal event is far more aligned after deconvolution has been applied demonstrating that the phase spectrum of the surface consistent distortions have been correctly estimated. msec Figure(1a) CDP gather displaying surface consistent phase rotations and time shifts with added noise Figure(1b) synthetic CDP gather from figure (1a) after surface consistent deconvolution The second example shows the effectiveness of the algorithm when applied to a real land vibroseis data set. Prior to deconvolution inverse Q-filtering deterministic zero phasing refraction statics surface consistent residual statics NMO and a sliding gate amplitude equalization had been applied to the data. The deterministic zero
Evidence for the involvement of ecto-5′-nucleotidase (CD73) in drug resistance (1996)

Increased ecto-5'-nucleotidase (ecto-5'NT) protein expression in several multidrug-resistant (MDR) cell lines, documented previously by our group, suggests that this enzyme is involved in drug resistance. Here, Northern blot analysis of selected cell lines and their MDR variants positively correlated ecto-5'NT protein with its mRNA expression. An inhibitor of ecto-5'NT enzymatic activity, alpha,beta-methyleneadenosine 5'-diphosphate (AMP-CP), was used to determine if functionally active enzyme had a role in drug resistance. AMP-CP (0.3 mM) reversed the resistance of ecto-5'NT-positive MDR cells (MCF7/A6, L1210/A) to doxorubicin, whereas it did not affect the doxorubicin sensitivity of the ecto-5'NT-negative parental cell lines or that of 2 ecto-5'NT-negative MDR cell lines (HL60/VCR and A2780/DX5). Furthermore, AMP-CP increased rhodamine uptake and inhibited rhodamine efflux from ecto-5'NT-positive MDR cells without affecting ecto-5'NT-negative MDR cells. The presence of exogenous adenosine (0.5 microM) circumvented AMP-CP-induced inhibition of rhodamine efflux from EL4/ADM cells. AMP-CP inhibited the growth of the ecto-5'NT-positive L1210/A MDR cells but had no effect on the growth of the parental cell line. Determination of intracellular ATP levels indicated that MDR cells which had increased ecto-5'NT expression also had a lower intracellular ATP level than their parental cells. Our results suggest that, in certain MDR cell lines, ecto-5'NT serves as a required accessory molecule in resistance mediated by ATP-dependent mechanisms and that growth-sustaining nucleosides are provided by this salvage pathway.
Electromagnetic Tomography for Medical and Industrial Applications: Challenges and Opportunities [Point of View] (2013)

MIT's (magnetic induction tomography) low-cost and noninvasive features can offer great excitement and potential to address many challenging problems that exist in the current industrial/medical applications. The foundation development of MIT has been made in the past ten years. Many more advancements can be expected in the next decade, including the first commercialized MIT system for industrial or medical application. It will certainly contribute some impact to the current imaging technology.
Advanced electronic tongue concept (2003)

This effort, directed at developing a sensor for evaluating water quality, is based on electrochemical techniques that detect and identify ions in solution. This paper discusses the use of Cyclic Voltammetry (CV), corrosion measurements, and Anodic Stripping Voltammetry (ASV) to measure three marker ions Cu, Fe, and Zn using the electronic tongue concept. The use of genetic algorithms is suggested as an approach to facilitate the search for optimum measurement conditions. In addition, the possibility of changing the physical conditions of the sample chamber is discussed as a way of increasing the sensor's apparent sensitivity of and confidence in the measurements.
Creating virtual platform for cloud computing (2010)

Web has become an open platform where everybody can build and run their applications. Big companies can manage the capital expenditure themselves. Small company or a user wants to provide web services, better they can rent the computing infrastructure. Infrastructure-as-a-Service (IaaS) is the delivery of computer infrastructure such as servers, network, applications, storage, software, hardware as a service. The customer is charged only for the resources consumed like utility based computing. Virtualization is a technique to implement cloud computing resources such as platform, application, storage, and network. The beauty of virtualization solutions is that you can run multiple virtual machines (VM) simultaneously on a single computer. This paper provides implementation details of creating virtual platform. i.e. virtual guest operating system running on Windows7 host.
Grain shape effects on dielectric and electrical properties of rocks (1984)

Abstract Recently there has been a considerable interest in the effect of anisotropy in the grain shape in the electrical and dielectrical properties of rocks and other inhomogeneous media (Sen 1981a, b; Sen et al, 1981; Mendelson and Cohen, 1982; and Kenyon, 1983). In this note I point out that equation (34) of Mendelson and Cohen (MC) is incorrect. The dc limit of MC equation (34) for the conductivity of rock σ, in terms of porosity φ and water conductivity σw, gives (1)Inφ=m̂−1Inσσw, or (2)σ=σwφm^, where (3)m^−1=〈1+2(1−3L)2(5−3L)(1+3L)−3L(1−L)1+3L〉.L is the depolarization factor along the principal axis of spheroidal grain and 〈 〉 denotes an average over the distribution in L. This value of m^ is in disagreement with the correct value of m in equation (28) of MC [equation (6) below]. [When the sign mistakes in equations MC (33)–(34) are corrected, m^=〈3(1−L2)/(5−3L)〉−1. This agrees with equation (6) below for the case when L has a single value and averaging is redundant.] This inconsistency arises from an incorrect replacement of the inverse of an average in MC equation (33) by an average of inverses. The corrected form of MC equation (33) is (4)−dφ3φ=dεε(εm−ε)..1〈(1+3L)εm+(5−3L)ε[Lεm+(1−L)ε][(1−L)εm+(1+L)ε]〉, where ε and εm are the dielectric constants of the mixture and of the matrix, respectively. The dielectric constant ε = ε′ + σ/iωε0 is complex, εm is real, ε0 is the permittivity of vacuum, σ the conductivity, ω the angular frequency. The last factor in the right-hand side of the equation was replaced incorrectly by the average of the inverse, which is incorrect in general. Note that in the dc limit equation (4) above gives (5)mdφφ=dσ(0)σ(0), and, by integration, σ(0)=σw(0)φm, where σw(0) is the dc conductivity of water, σ(0) is the dc conductivity of formation, and (6)m=〈5−3L3(1−L2)〉.