gebhart/patrepeval huggingface dataset:
Is the Biological Artificial Liver Clinically Applicable? A Historic Review of Biological Artificial Liver Support Systems (1994)

Hemoperfusion, hemodiafiltration, plasma exchange, and extracorporeal liver perfusion have already been adopted to treat patients with acute and chronic hepatic failure. However, the survival rate of patients with acute hepatic failure remains at approximately 30% and has not improved as expected. Current advances in biotechnology have opened the way for the development of a biological artificial liver, which is called the hybrid artificial liver because it consists of both biological and artificial materials. Isolated hepatocytes have been investigated for use in various types of hybrid artificial liver. In addition, the role of biomatrices, microcarriers, and the microencapsulation technique has been studied with respect to long-term maintenance of hepatocellular function and development of high-density culture systems for hepatocytes. Before clinical application of hybrid artificial liver support systems becomes possible, many problems have to be resolved, including large-scale preparation and long-term preservation of biomaterials, high-density and stable immobilization of biomaterials on artificial materials, control of immunological hazards, biocompatibility, safe transportation and sterilization of biomaterials, and the high cost. We review the history of biological artificial livers and discuss their future role.
Monensin prevents terminal glycosylation of the N- and O-linked oligosaccharides of the HLA-DR-associated invariant chain and inhibits its dissociation from the alpha-beta chain complex. (1984)

In B-lymphoblastoid cells, the HLA-DR-associated invariant chain is processed to a form containing O-linked as well as N-linked oligosaccharides. After neuraminidase treatment, the O-linked carbohydrate is susceptible to digestion with an endoglycosidase (endo-beta-N-acetylgalactosaminidase) that cleaves glycans with the structure Gal(beta 1----3)-GalNAc-Ser/Thr, and sialic acid can be added back to this core oligosaccharide by specific sialyltransferases. Treatment of cells with the sodium ionophore monensin markedly affects the post-translational processing of the invariant chain, although that of associated alpha and beta chains is minimally affected. Only a small portion of the N-linked carbohydrate on the invariant chain is processed to an endoglycosidase-H-resistant form. The sialic acid residues normally found on the O-linked glycans are not added, but at least the first residue, GalNAc, is added. In addition to the changes in glycosylation, an intracellular accumulation of HLA-DR antigens also occurs in monensin-treated cells. The accumulation of HLA-DR antigens and the overall slower turnover rates of the alpha, beta, and invariant polypeptides observed after monensin treatment probably reflects the build-up of newly synthesized proteins in Golgi apparatus-derived vacuoles coupled with a decrease in normal degradation in lysosomes.
Surface plasmon resonance and immunosensors (1984)

A rough surface analysis of surface plasmon resonance (SPR) is applied to a glass/silver/antigen/antibody/electrolyte multilayer. Comments are made on the experimental arrangements most appropriate to the development of SPR immunosensors.
Hybridized wavefront shaping for high-speed, high-efficiency focusing through dynamic diffusive media (2016)

One of the prime limiting factors of optical imaging in biological applications is the diffusion of light by tissue, which prevents focusing at depths greater than the optical diffusion limit (typically ?1??mm). To overcome this challenge, wavefront shaping techniques that use a spatial light modulator (SLM) to correct the phase of the incident wavefront have recently been developed. These techniques are able to focus light through scattering media beyond the optical diffusion limit. However, the low speeds of typically used liquid crystal SLMs limit the focusing speed. Here, we present a method using a digital micromirror device (DMD) and an electro-optic modulator (EOM) to measure the scattering-induced aberrations, and using a liquid crystal SLM to apply the correction to the illuminating wavefront. By combining phase modulation from an EOM with the DMD’s ability to provide selective illumination, we exploit the DMD’s higher refresh rate for phase measurement. We achieved focusing through scattering media in less than 8 ms, which is sufficiently short for certain in vivo applications, as it is comparable to the speckle correlation time of living tissue.
V.—MEANING AND RULES OF USE (1962)

V.—MEANING AND RULES OF USE Get access ROBERT BROWN ROBERT BROWN Australian National University Search for other works by this author on: Oxford Academic Google Scholar Mind, Volume LXXI, Issue 284, October 1962, Pages 494–511, https://doi.org/10.1093/mind/LXXI.284.494 Published: 01 October 1962
Human-Machine Collaborative surgery using learned models (2011)

In the future of surgery, tele-operated robotic assistants will offer the possibility of performing certain commonly occurring tasks autonomously. Using a natural division of tasks into subtasks, we propose a novel surgical Human-Machine Collaborative (HMC) system in which portions of a surgical task are performed autonomously under complete surgeon's control, and other portions manually. Our system automatically identifies the completion of a manual subtask, seamlessly executes the next automated task, and then returns control back to the surgeon. Our approach is based on learning from demonstration. It uses Hidden Markov Models for the recognition of task completion and temporal curve averaging for learning the executed motions. We demonstrate our approach using a da Vinci tele-surgical robot. We show on two illustrative tasks where such human-machine collaboration is intuitive that automated control improves the usage of the master manipulator workspace. Because such a system does not limit the traditional use of the robot, but merely enhances its capabilities while leaving full control to the surgeon, it provides a safe and acceptable solution for surgical performance enhancement.
Localization of Inhibin and Activin Binding Sites in the Testis during Development by in Situ Ligand Binding (1994)

Inhibin and activin are related proteins thought to be potential paracrine regulators of testicular development and maintenance of spermatogenesis. Messenger RNA and proteins immunologically related to both factors have been identified in the adult testis. However, the role(s) of these factors in paracrine regulation of testicular function is poorly understood. To identify potential targets for inhibin and activin in immature and adult testis, we used in situ binding of [125I]-labeled ligands to localize and describe the distribution of binding sites for inhibin and activin in testes of 15-, 18-, 21-, 30-, 45-, and 60-day-old rats. Nonspecific binding was defined as that occurring in the presence of a 1000-fold excess of unlabeled recombinant human (rh) inhibin or activin. [125I]-Inhibin was found to bind to interstitial cells throughout development. Inhibin binding was shown to co-localize with cells that showed positive staining for 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD). Competition studies demonstrated that this binding was indeed specific for inhibin. In contrast, [125I]-activin showed two distinct patterns of binding. First, [125I]-activin was shown to bind in a non-stage-dependent manner to cells located in the basal compartment of the seminiferous tubules in testis obtained from animals of all ages studied. Binding of [125I]-activin in the periphery of the tubule could be inhibited entirely by coincubation with excess unlabeled activin and partially with excess unlabeled inhibin. The ability of inhibin to compete with activin for binding appeared to be more pronounced in younger animals. In 45- and 60-day-old animals, a second stage-dependent component of [125I]-activin binding was also apparent. This binding was localized to spermatids found in stage VII-VIII tubules and was inhibited by the presence of excess activin, but not inhibin. These results indicate that inhibin can bind specifically to testicular interstitial cells throughout development and may be an important regulator of Leydig cell testosterone production or interstitial cell function. In contrast, activin appears to bind in a specific and stage-dependent manner to receptors or high-affinity binding proteins on spermatids as well as to sites on the periphery of all seminiferous tubules. These results support the hypothesis that both activin and inhibin may act at several levels to regulate proliferation or differentiation of germ and Sertoli cell function as well as to modulate interstitial cell activity.
Study of the Second-Order Ferroelectric Transition in Tri-Glycine Sulfate (1958)

Results of measurements of the dielectric constant, dielectric nonlinearity and spontaneous polarization of tri-glycine sulfate are given. These data demonstrate clearly that this material exhibits a second-order ferroelectric transition. The properties discussed are described in terms of the usual expansion of the free energy in even powers of the polarization F(P,T)=F(O,T)+A(T-T <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> )P <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> +BP <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> +CP <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> , where A,T <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> ,B and C are constants and T and P are the temperature and polarization, respectively. From the various data taken it is found that A=1.96×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−3</sup> (°C) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−1</sup> , T <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> =49.8°C,B=2.0×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−10</sup> (esu/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> and C=8.4×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−19</sup> (esu/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−4</sup> . From these results the nonlinearity of the dielectric constant above the Curie point is calculated at various temperatures.
Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex (2018)

Endoplasmic reticulum (ER) stress triggers or amplifies inflammatory signals and cytokine production in immune cells. Upon the resolution of ER stress, the inducible phosphatase 1 cofactor GADD34 promotes the dephosphorylation of the initiation factor eIF2α, thereby enabling protein translation to resume. Several aminoguanidine compounds, such as guanabenz, perturb the eIF2α phosphorylation-dephosphorylation cycle and protect different cell or tissue types from protein misfolding and degeneration. We investigated how pharmacological interference with the eIF2α pathway could be beneficial to treat autoinflammatory diseases dependent on proinflammatory cytokines and type I interferons (IFNs), the production of which is regulated by GADD34 in dendritic cells (DCs). In mouse and human DCs and B cells, guanabenz prevented the activation of Toll-like receptor 9 (TLR9) by CpG oligodeoxynucleotides or DNA-immunoglobulin complexes in endosomes. In vivo, guanabenz protected mice from CpG oligonucleotide-dependent cytokine shock and decreased autoimmune symptom severity in a chemically induced model of systemic lupus erythematosus. However, we found that guanabenz exerted its inhibitory effect independently of GADD34 activity on eIF2α and instead decreased the abundance of CH25H, a cholesterol hydroxylase linked to antiviral immunity. Our results therefore suggest that guanabenz and similar compounds could be used to treat type I IFN-dependent pathologies and that CH25H could be a therapeutic target to control these diseases.
IGF‐I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death (2009)

Retinitis pigmentosa is a heterogeneous group of inherited retinal dystrophies in which the loss of photoreceptor cells via apoptosis leads to blindness. In this study we have experimentally mimicked this condition by treating 661W cells and wild-type mouse retinal explants with a Ca(2+) ionophore. Ca(2+) overload induced apoptosis, which was correlated with calpain-2 activation, loss of calpastatin, its endogenous inhibitor, as well as the loss of its transcriptional activator, phospho-cAMP response element binding (CREB). All are similar changes to those observed in the rd1 mouse model of retinitis pigmentosa. Insulin like-growth factor-I (IGF-I) attenuated this Ca(2+)-induced apoptosis, as well as decreased the activation of calpain-2 and maintained calpastatin levels through the activation of the Akt-CREB pathway. Similarly, IGF-I decreased photoreceptor apoptosis in rd1 mouse retinal explants in parallel with reduced activation of calpain-2 and increased levels of calpastatin and activation of phospho-CREB. In conclusion, IGF-I seems to protect neural cells following a physiopathological or an experimental increase in intracellular Ca(2+), an observation that may have therapeutic consequences in neurodegenerative diseases such as retinitis pigmentosa.
Role of integrin α<sub>1</sub>β<sub>1</sub>in the regulation of renal medullary osmolyte concentration (2005)

The mechanism by which cells sense extracellular tonicity and trigger the accumulation of protective organic osmolytes is poorly understood. It has been proposed that changes in cell volume following alteration of extracellular toncity are important initiators of signaling events that lead to osmolyte accumulation. Because the extracellular matrix receptors integrins are linked to the cytoskeleton and can transduce signals that alter cell behavior, we investigated the role of these receptors in the modulation of osmolyte accumulation in the kidney medulla under different osmotic conditions. We show that integrin alpha1-null mice have impaired ability to accumulate organic osmolytes in the inner medulla due to altered signaling and decreased induction of osmolyte transporters or aldose reductase gene transcription. Utilizing inner medullary collecting duct cells, we demonstrate that the lack of integrin alpha1beta1 results in an impaired ability to induce the tonicity enhancer-binding protein TonEBP under hypertonic conditions. Furthermore, under the same conditions, integrin alpha1-null cells show prolonged ERK1/2 phosphorylation and decreased inositol uptake compared with control cells. The reduction of inositol uptake is significantly reversed by treatment with the MEK inhibitor PD-98059. Finally, integrin alpha1-null mice develop morphological changes of early tubular necrosis and increased apoptosis of renal medullary cells following dehydration. Together, these results show that integrin alpha1beta1 is an important mediator of the compatible osmolyte response in the medulla of the mammalian kidney.
On the Origins of Spontaneous Polarization in Tilted Smectic Liquid Crystals (1995)

The rapid electrooptic response of ferroelectric liquid crystals-stratified (smectic) melts exhibiting spontaneous electric polarization-makes them candidates for the next generation of electrooptic shutters and liquid crystal displays. The model advanced here suggests that polarity is indigenous to tilted smectics and that spontaneous polarization derives from the packing constraints mesogens experience, a tilt-dependent correlation of molecular conformation with orientation. First-rank orientational order parameters ( C xX ) are nonzero with a tilt- (temperature-) dependent magnitude, and under certain packing conditions, the sign of C xX varies with tilt. These results have a direct bearing on experimental observations because most ferroelectric liquid crystals exhibit a tilt-dependent spontaneous polarization and some show an inversion of the sign of the polarization.
Excitability of chronic hemiparetic muscles: determination of chronaxie values and strength-duration curves and its implication in functional electrical stimulation (2005)

Central nervous system disorders affect the anatomy and physiology of the lower motoneuron. This fact has an impact on the stimulation parameters, especially on the duration of the stimulating impulses, for functional electrical stimulation in chronic hemiparetic patients. The aim of this study was thus to test the excitability and to determine chronaxie values and strength-duration curves of weak wrist and finger extensor muscles and spastic finger and wrist flexor muscles in the hemiparetic arm. Twelve patients with chronic hemiplegia (>6 months after the onset of the cerebral lesion) participated in the study. A constant current stimulator was used. As to chronaxie values no significant differences were found between the extensor muscles (mean+/-SD: 0.44+/-0.16 ms) and flexor muscles (mean+/-SD: 0.36+/-0.22 ms). A moderate variability was seen for both extensor muscles (0.2-0.8 ms) and flexor muscles (0.1-0.9 ms). These values are well within the normal range determined for innervated muscles. All strength-duration curves were completely normal for each muscle. We conclude that in chronic hemiparetic muscles, impulses of the same duration can be used as in muscles of healthy subjects.
Nonuniformity Correction Based on Adaptive Sparse Representation Using Joint Local and Global Constraints Based Learning Rate (2018)

The infrared focal plane array (IRFPA) suffers from the problem of non-uniform photoelectric responsivity of infrared detectors, namely nonuniformity. This paper aims at removing the fixed pattern noise (FPN) brought by nonuniformity in IRFPA through scene-based nonuniformity correction (SBNUC). Different from traditional neural network-based methods where spatial filters are adopted, a new approach of acquiring the desired image (the target of optimization task) is proposed, which is based on the sparse representation theory. The sparse representation of the image corrected by the current correction coefficients is used as the desired image. During sparse coding, the error tolerance is computed from an adaptive criterion, which is negatively correlated to the root-mean-square error between the input image and the corrected image. The resulted desired image is more accurate than its counterparts in traditional filter-based methods, as the edges can be preserved without heavily blurring image details, while the elements of FPN are omitted as redundant when coding the representation coefficients. To suit this desired image, a new adaptive learning rate based on joint local and global constraints is proposed. Different from traditional local spatial standard deviation-based learning rate, the constraints are calculated based on the variations among the input image, the corrected image, and the desired image. A new motion detection rule is also incorporated to this learning rate, which could be maximized to accelerate convergence only if the scene motion is sufficient both globally and locally. Experiments are conducted on both public infrared image sets (the Video Verification of Identity program data set and the Automonous Systems Lab data set) and a private infrared sequence. Experimental results demonstrate that, the proposed method achieves better performance of FPN removal on infrared sequences with both simulated and real nonuniformity, compared with SBNUC methods based on spatial filter (including Gaussian filter, guided filter, and bilateral filter).
Semantically Enhanced Containers for Concurrent Real-Time Systems (2009)

Future space missions, such as Mars Science Laboratory, are built upon computing platforms providing a high degree of autonomy and diverse functionality. The increased sophistication of robotic spacecraft has skyrocketed the complexity and cost of its software development and validation. The engineering of autonomous spacecraft software relies on the availability and application of advanced methods and tools that deliver safe concurrent synchronization as well as enable the validation of domain-specific semantic invariants. The software design and certification methodologies applied at NASA do not reach the level of detail of providing guidelines for the development of reliable concurrent software. To achieve effective and safe concurrent interactions as well as guarantee critical domain-specific properties in code, we introduce the notion of a Semantically Enhanced Container (SEC). A SEC is a data structure engineered to deliver the flexibility and usability of the popular ISO C++ Standard Template Library containers, while at the same time it is hand-crafted to guarantee domain-specific policies. We demonstrate the SEC proof-of-concept by presenting a shared nonblocking SEC vector. To eliminate the hazards of the ABA problem (a fundamental problem in lock-free programming), we introduce an innovative library for querying C++ semantic information. Our SEC design aims at providing an effective model for shared data access within the JPL's Mission Data System. Our test results show that the SEC vector delivers significant performance gains (a factor of 3 or more) in contrast to the application of nonblocking synchronization amended with the traditional ABA avoidance scheme.
Statistical n-butyl acrylate-sulfopropyl betaine copolymers. 3. Domain size determination by solid-state NMR spectroscopy (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStatistical n-butyl acrylate-sulfopropyl betaine copolymers. 3. Domain size determination by solid-state NMR spectroscopyMarc Ehrmann, Jean Claude Galin, and Bernard MeurerCite this: Macromolecules 1993, 26, 5, 988–993Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/ma00057a017https://doi.org/10.1021/ma00057a017research-articleACS PublicationsRequest reuse permissionsArticle Views127Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts