gebhart/patrepeval huggingface dataset:
Estrogen Receptor-α Binds p53 Tumor Suppressor Protein Directly and Represses Its Function (2006)

Estrogen receptor-alpha (ERalpha) promotes proliferation of breast cancer cells, whereas tumor suppressor protein p53 impedes proliferation of cells with genomic damage. Whether there is a direct link between these two antagonistic pathways has remained unclear. Here we report that ERalpha binds directly to p53 and represses its function. The activation function-2 (AF-2) domain of ERalpha and the C-terminal regulatory domain of p53 are necessary for the interaction. Knocking down p53 and ERalpha by small interfering RNA elicits opposite effects on p53-target gene expression and cell cycle progression. Remarkably, ionizing radiation that causes genomic damage disrupts the interaction between ERalpha and p53. Ionizing radiation together with ERalpha knock down results in additive effect on transcription of endogenous p53-target gene p21 (CDKN1) in human breast cancer cells. Our findings reveal a novel mechanism for regulating p53 and suggest that suppressing p53 function is an important component in the pro-proliferative role of ERalpha.
Quantitative Results Comparing Three Intelligent Interfaces forInformation Capture: A Case Study Adding Name Information into a (1996)

Efficiently entering information into a computer is key to enjoying the benefits of computing. This paper describes three intelligent user interfaces: handwriting recognition, adaptive menus, and predictive fillin. In the context of adding a personUs name and address to an electronic organizer, tests show handwriting recognition is slower than typing on an on-screen, soft keyboard, while adaptive menus and predictive fillin can be twice as fast. This paper also presents strategies for applying these three interfaces to other information collection domains.
Lessons Learned from the Deployment and Maintenance of UBI-Hotspots (2010)

We provide an experience report of the deployment and maintenance of urban computing infrastructure called UBI-hotspot. It is effectively a large interactive public display embedded with other computing resources such as access points of different wireless networks. We have installed a network of 12 UBI-hotspots in key indoor and outdoor locations around downtown Oulu, Finland. We describe the remote monitoring and management tools we have adopted for the maintenance of the UBI-hotspots. We conclude with a discussion on our lessons learned which should be valuable for other researchers planning similar deployments in public urban spaces.
Predicting the prognosis in acute liver failure: results from a retrospective pilot study using the LiMAx test (2013)

Maximal liver function capacity determined by LiMAx test is severely impaired in patients with ALF. The LiMAx test might be effective in predicting the individual prognosis and the need for LTX in ALF.
Reductive Dechlorination of 1,2,3,4-Tetrachlorodibenzo-<i>p</i>-dioxin and Its Products by Anaerobic Mixed Cultures from Saale River Sediment (1997)

The capability of anaerobic bacterial consortia from different environmental sources including soils, sewage sludges, and sediment of the river Saale (Germany) to dehalogenate chlorinated dioxins was compared using 1,2,3,4-tetrachlorodibenzo-p-dioxin (1,2,3,4-TCDD) as the model compound. The inocula were amended with mineral medium and organic acids and spiked with a high concentration (50 μM) of 1,2,3,4-TCDD to stimulate microbial dehalogenating activity. Reductive dechlorination was observed to 1,3-dichlorodibenzo-p-dioxin (1,3-DCDD) as the main product and to minor amounts of the 1,2,4- and 1,2,3-trichlorodibenzo-p-dioxins (TrCDD) using incubations with Saale River sediment. No reaction was observed in the controls and in incubations with soils or sewage sludges. The dechlorination of 1,2,4- and 1,2,3-TrCDD was analyzed in separate subcultures. Reductive dechlorination of 1,2,4-TrCDD was a relative fast process (about 6 μM converted within 58 days) and yielded only one product (1,3-DCDD). 1,2,3-TrCDD was slowly dechlorinated to equal amounts of 1,3- and 2,3-DCDD. These observations suggest that the main dechlorination route of 1,2,3,4-TCDD to 1,3-DCDD proceeds primarily via the removal of a lateral chlorine atom with 1,2,4-TrCDD as the intermediate.
Preparation of Helper-Dependent Adenoviral Vectors (2003)

Adenoviruses (Ads) are excellent mammalian gene transfer vectors because of their ability to infect efficiently a wide variety of quiescent and proliferating cell types from various species to direct high-level gene expression. Consequently, Ad vectors are extensively used as potential recombinant viral vaccines, for high-level protein production in cultured cells and for gene therapy (1–4). First-generation Ad vectors typically have foreign DNA inserted in place of early region 1 (E1). E1-deleted vectors are replication deficient and are propagated in E1-complementing cells such as 293 (5). Although these vectors remain very useful for many applications, it has become clear that transgene expression in vivo is only transient. Several factors contribute to this, including strong innate and inflammatory responses to the vector (6,7), acute and chronic toxicity caused by low-level viral gene expression from the vector backbone (8), and generation of anti-Ad cytotoxic T-lymphocytes caused by de novo viral gene expression (9–12) or processing of virion proteins (13). Although high-level transient transgene expression afforded by first-generation Ad vectors may be adequate, or even desirable, for many gene transfer and gene therapy applications, the transient nature of expression kinetics renders these vectors unsuitable when prolonged, stable expression is required.
Design of ultra-wideband antenna matching networks (2007)

In this review paper, modern methods, so called the real frequency techniques to design broadband matching network are covered, a design roadmap is given with relevant recommendations. Measured performances of the recently designed and manufactured ultra-wideband matching circuits are outlined for various applications.
Development of an Australian Standard for Wheelchair Occupant Restraint Assemblies for Motor Vehicles (1987)

An Australian Standard for Wheelchair Occupant Restraint Assemblies for Motor Vehicles has been produced. Titled Australian standard 2942-1987, Wheelchair Occupant Restraint Assemblies for Use in Motor Vehicles, it establishes design and performance requirements for these restraints, and includes details of dynamic testing procedures. Under the Standard, a lap belt is the basic occupant restraint required with the wheelchair restrained independently of the occupant. The Standard, instead of specifying a "standard" design for wheelchair occupant restraint assemblies, is intended to ensure effective crash protection for wheelchair occupants with a minimum of restriction on the design of restraints. It requires that instructions for installation and use of restraints be provided. Also included in the Standard is an advisory section providing general information for restraint users such as the types of wheelchairs best suited for use in vehicles. This appears to be the first national Standard for wheelchair occupant restraint assemblies for motor vehicles, and may well form the basis of similar standards elsewhere.
Layered and pillared zirconium phosphate-phosphonates and their inclusion chemistry (1995)

Abstract After a brief account on previous results obtained in this Laboratory in the field of layered and pillared α- and γ-zirconium phosphonates, the perspectives for a development of a “molecular recognition” in porous and in layered solids are examined. In particular, the preparation and the preliminary characterisation of some new zirconium phosphonates more specifically designed for a “molecular recognition”, such as: a) layered and pillared derivatives of γ-zirconium phosphate containing crown ethers in the interlayer region, b) α-layered zirconium phosphate containing chiral centres anchored to its surface and c) pillared derivatives of γ-zirconium phosphate containing non rigid pillars, are reported and discussed.
Synthesis and in Vitro Evaluation of BBB Permeability, Tumor Cell Uptake, and Cytotoxicity of a Series of Carboranylporphyrin Conjugates (2014)

A series of tri[(p-carboranylmethylthio)tetrafluorophenyl]porphyrin conjugates of linear and branched polyamines, glucose, arginine, tri(ethylene glycol), and Tyr-D-Arg-Phe-β-Ala (YRFA) peptide were synthesized. These conjugates were investigated for their BBB permeability in human hCMEC/D3 brain endothelial cells, and their cytotoxicity and uptake were assessed using human glioma T98G cells. For comparison purposes, a symmetric tetra[(p-carboranylmethylthio)tetrafluorophenyl]porphyrin was also synthesized, and its crystal structure was obtained. All porphyrin conjugates show low dark cytotoxicity (IC50>400 μM) and low phototoxicity (IC50>100 μM at 1.5 J/cm2) toward T98G cells. All conjugates were efficiently taken up by T98G cells, particularly the cationic polyamine and arginine conjugates, and were localized in multiple cellular organelles, including mitochondria and lysosomes. All compounds showed relatively low in vitro BBB permeability compared with that of lucifer yellow because of their higher molecular weight, hydrophobicity, and tendency for aggregation in solution. Within this series, the branched polyamine and YRFA conjugates showed the highest permeability coefficient, whereas the glucose conjugate showed the lowest permeability coefficient.
24 Kinds of Traditional Chinese Medicine Monomer Components in Treatment of Alzheimer's Disease (2013)

Alzheimer's disease is an important degenerative neurological disease.With the increase of incidence,AD is a serious disease which threatens the health of human beings.It also affects the development of society.The pathogenesis of AD is very complex.At present,there is no theory which can completely explain the pathogenesis of AD,and there is no effective drug or method to treat the Alzheimer's disease.In recent years,more and more attention has been paid in the research on prevention and treatment of AD by traditional Chinese medicine and it's extractant,especially some monomer components of flavone,alkaloid and saponins.In this article,the progress of study in AD's prevention and treatment by monomer components was reviewed.
<i>Arabidopsis</i> Acetohydroxyacid Synthase Expressed in <i>Escherichia coli</i> Is Insensitive to the Feedback Inhibitors (1992)

Acetohydroxyacid synthase (AHAS), the first enzyme unique to the biosynthesis of isoleucine, leucine, and valine, is the target enzyme for several classes of herbicides. The AHAS gene from Arabidopsis thaliana, including the chloroplast transit peptide, was cloned into the bacterial expression plasmid pKK233-2. The resulting plasmid was used to transform an AHAS-deficient Escherichia coli strain MF2000. The growth of the MF2000 strain of E. coli was complemented by the functional expression of the Arabidopsis AHAS. The AHAS protein was processed to a molecular mass of 65 kilodaltons that was similar to the mature protein isolated from Arabidopsis seedlings. The AHAS activity extracted from the transformed E. coli cells was inhibited by imidazolinone and sulfonylurea herbicides. AHAS activity extracted from Arabidopsis is inhibited by valine and leucine; however, this activity was insensitive to these feedback inhibitors when extracted from the transformed E. coli.
The Chemistry of Phosphapeptides: Investigations on the Synthesis of Phosphonamidate, Phosphonate, and Phosphinate Analogs of Glutamyl-.gamma.-glutamate (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chemistry of Phosphapeptides: Investigations on the Synthesis of Phosphonamidate, Phosphonate, and Phosphinate Analogs of Glutamyl-.gamma.-glutamateWilliam P. Malachowski and James K. CowardCite this: J. Org. Chem. 1994, 59, 25, 7625–7634Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://doi.org/10.1021/jo00104a017RIGHTS & PERMISSIONSArticle Views831Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Rigid and Flexible: A Highly Porous Metal–Organic Framework with Unusual Guest‐Dependent Dynamic Behavior (2004)

A large H2 sorption capacity and high surface area are properties of the depicted metal–organic porous material, which is easily synthesized on a large scale from readily available chemicals. The rigid framework of [Zn2(1,4-bdc)2(dabco)] (1,4-H2bdc=1,4-benzenedicarboxylic acid; dabco=diazabicyclo[2.2.2]octane) is also flexible enough to exhibit unusual guest-dependent dynamic behavior, as shown (DMF=N,N-dimethylformamide).
Lethal photosensitization of periodontal pathogens by a red‐filtered Xenon lamp <i>in vitro</i> (2003)

The data indicate that PDT utilizing a conventional light source is at least as effective as laser-induced treatment in vitro. Furthermore, PDT achieves significant bactericidal activity in the presence of serum and blood when used with the set parameters of 10 J/cm2, 100 mW/cm2 and 12.5 micro g/ml TBO.
Have we really thought through health reform (2006)

\n\t\t\t\t\tWith all the discussion around about health care reform in Australia we are missing a fundamental issue about health and illness. They are not the same! There is a disconnect between the rhetoric of reform, the apparent political support for prevention and health promotion, and the realities of decisions being taken and understanding of the underlying assumptions of health determinants.Preventing ill health and promoting health have been seen as the point of departure for good health care, at least rhetorically, ever since the Alma Ata Declaration (1978) and the Ottawa Charter (1986). Australia along with other member states of the WHO is signatories to both and they have underpinned official health policy with a rhetorical flourish in many a document since.\n\t\t\t\t
Loss calculations of the hollow-core, oxide-glass-cladding, middle-infrared optical waveguides (1982)

The loss characteristics of hollow-core, oxide-glass-cladding, middle infrared (near 1000 cm−1) optical waveguide is calculated numerically for TE01, TM01, and HE11 modes. The oxide-glass cladding used has its refractive index nr less than unity; their transmission losses of the waveguide are relatively small due to total reflection effect. The necessity condition of complex refractive index nr -ik of the cladding is clarified to be used with such hollow-core optical waveguides.
Intercalative and nonintercalative binding of large cationic porphyrin ligands to calf thymus DNA (1983)

The large meso-substituted porphine, meso-tetra(4-N-methylpyridyl)porphine has been identified as a DNA-interactive ligand with a capacity for intercalation (1,2). Subsequently, the 2-N-methyl, 3-N-methyl and N-trimethylanilinium analogues of this porphyrin intercalator have been obtained for physico-chemical analyses (absorption spectroscopy, viscometry, circular dichroism, unwinding of supercoiled DNA). In this paper we discuss the factors affecting the character of porphyrin binding (intercalative, as is the case for the 4-N-methyl and 3-N-methyl porphines, versus non-intercalative, as is the case for the 2-N-methyl and N-trimethylanilinium porphines) and the impact that porphyrins' binding has upon the structure of DNA. The molecular conformation of the porphyrin ligand varies slightly within this series so that the ability of a given porphyrin to intercalate may be correlated with the arrangement of charged groups, the planarity of the porphine ring and the effective width of the individual molecules. The results from these studies indicate that sequence selective binding occurs within a small aperture of solution conditions.
Linear and nonlinear methods for analyses of cardiovascular variability in bipolar disorders (2006)

Prospective studies of cardiovascular changes in mania and depression are needed to evaluate a psychopathological state in connection with cardiovascular changes and cardiac morbidity and mortality. These studies should consider BPV, coupling and interaction analyses, the application of nonlinear methods, and a multivariate approach in addition to the traditional analysis of HRV.
Proposal of a new method for narrowing and moving the stimulated region of cochlear implants: animal experiment and numerical analysis (1999)

We have proposed the tripolar electrode stimulation method (TESM) for narrowing the stimulation region and continuously moving the stimulation site for cochlear implants. The TESM stimulates the auditory nerve array using three adjacent electrodes which are selected among the electrodes of an electrode array within the lymphatic fluid. Current is emitted from each of the two lateral electrodes and received by the central electrode. The current received by the central electrode is made equal to the sum of the currents emitted from the lateral electrodes. In this paper, we evaluate whether or not TESM works according to a theory which is based on numerical analysis using an electrical equivalent circuit model of the auditory nerve fibers. In this simulation, the sums of the excited model fibers are compared to the compound action potentials (CAP's) which we obtained through animal experiments. To identify the main parameter while maintaining the amplitude of the CAP (the sum of the fired fibers), we assumed the presence of some parameters from the radial current density profile. In the case of the width value among the parameters being kept constant, the amplitude of the CAP was almost constant; thus, the number of the fired fibers was also almost constant. The width value equals the distance between the points at which the profile of the radial current density of the electrode array and the line of the radial threshold current density of the electrode array intersect. It is possible to determine the measure of the stimulation region or site by controlling the width value and the ratios of the currents emitted from the lateral electrodes. As a result, we succeeded in narrowing the stimulation region by controlling the sum of the currents emitted from the two lateral electrodes. Also we succeeded in continuously moving the stimulation site by modifying the currents emitted from the two lateral electrodes.
Anthocyanin Composition of Black Carrot (Daucus carota ssp. sativus var. atrorubens Alef.) Cultivars Antonina, Beta Sweet, Deep Purple, and Purple Haze (2011)

This study aimed to identify the pigment composition of black carrot (Daucus carota ssp. sativus var. atrorubens Alef.) cultivars Antonina, Beta Sweet, Deep Purple, and Purple Haze. Cyanidin 3-xylosyl(glucosyl)galactosides acylated with sinapic acid, ferulic acid, and coumaric acid were detected as major anthocyanins by high-performance liquid chromatography with diode array detection (HPLC-DAD) and with electrospray ionization multiple mass spectrometry (HPLC-ESI-MS(n)) analyses. The preparative isolation of these pigments was carried out by means of high-speed countercurrent chromatography (HSCCC). The color activity concept was applied to the isolated anthocyanins at three pH values. Cyanidin 3-xylosyl(sinapoylglucosyl)galactoside was found to exhibit a lower visual detection threshold and a higher pH stability than cyanidin 3-xylosyl(feruloylglucosyl)galactoside and cyanidin 3-xylosyl(coumaroylglucosyl)galactoside. The color parameters of the fresh roots of the four cultivars were described by the CIELab coordinates L* (lightness), C* (chroma), and h(ab) (hue angles). Total phenolics varied among the cultivars and ranged from 17.9 to 97.9 mg gallic acid equivalents (GAE)/100 g fresh weight (fw). For the content of monomeric anthocyanins, values between 1.5 and 17.7 mg/100 g fw were determined.
Converting <i>gem</i>-Dimethyl Groups into Cyclopropanes via Pd-Catalyzed Sequential C−H Activation and Radical Cyclization (2006)

A novel route to the synthesis of cyclopropane derivatives is described. 1,1-Dimethyls in 2-(1,1-dimethylalkyl)dimethyloxazolines are first converted into 1,3-diiodide derivatives via Pd-catalyzed sequential C-H activation and then radically cyclized to provide 2-(1-alkylcylclopropyl)dimethyloxazolines. The use of EtOAc as a solvent is crucial for the diiodination of the functionalized substrates. [reaction: see text]
Orally available compound prevents deficits in memory caused by the Alzheimer amyloid‐β oligomers (2006)

A small, orally available natural product penetrates into the brain in vivo to rescue the memory impairment produced by soluble Abeta oligomers through a mechanism that restores hippocampal synaptic plasticity.
Resource-Efficient Real-Time Scheduling Using Credit-Controlled Static-Priority Arbitration (2011)

A present-day System-on-Chip (SoC) runs a wide range of applications with diverse real-time requirements. Resources, such as processors, interconnects and memories, are shared between these applications to reduce cost. Resource sharing causes temporal interference, which must be bounded by a suitable resource arbiter. System-level analysis techniques use the service guarantee of the arbiter to ensure that real-time requirements of these applications are satisfied. A service guarantee that underestimates the minimum service provided by an arbiter results in more allocation of resources than needed to satisfy latency and throughput requirements. For instance, a linear service guarantee cannot accurately capture burst service provision by many priority-based schedulers, such as Credit-Controlled Static Priority (CCSP) and Priority-Budget Scheduling (PBS). As a result, the timing analysis of these arbiters becomes too pessimistic. This leads to unnecessary cost penalties since some SoC resources, such as SDRAM bandwidth, are scarce and expensive. This paper addresses this problem for the CCSP arbiter. The two main contributions are: (1) a piecewise linear service guarantee that accurately captures bursty service provisioning, and (2) an equivalent dataflow model of the new service guarantee, which is an essential component to integrate the arbiter with dataflow-based system-level design techniques that analyze the worst-case latency and throughput of real-time applications. The new service guarantee enables efficient resource utilization under CCSP arbitration. Experimental results of an H.263 video decoder application show that memory bandwidth savings from 26% up to 67% can be achieved by using the new service guarantee as compared to the existing linear service guarantee.