gebhart/patrepeval huggingface dataset:
Neutrophils and their Fc  receptors are essential in a mouse model of transfusion-related acute lung injury (2006)

Transfusion-related acute lung injury (TRALI) is the most common cause of transfusion-related mortality. To explore the pathogenesis of TRALI, we developed an in vivo mouse model based on the passive transfusion of an MHC class I (MHC I) mAb (H2Kd) to mice with the cognate antigen. Transfusion of the MHC I mAb to BALB/c mice produced acute lung injury with increased excess lung water, increased lung vascular and lung epithelial permeability to protein, and decreased alveolar fluid clearance. There was 50% mortality at a 2-hour time point after Ab administration. Pulmonary histology and immunohistochemistry revealed prominent neutrophil sequestration in the lung microvasculature that occurred concomitantly with acute peripheral blood neutropenia, all within 2 hours of administration of the mAb. Depletion of neutrophils by injection of anti-granulocyte mAb Gr-1 protected mice from lung injury following MHC I mAb challenge. FcRgamma-/- mice were resistant to MHC I mAb-induced lung injury, while adoptive transfer of wild-type neutrophils into the FcRgamma-/- animals restored lung injury following MHC I mAb challenge. In conclusion, in a clinically relevant in vivo mouse model of TRALI using an MHC I mAb, the mechanism of lung injury was dependent on neutrophils and their Fc gamma receptors.
Energy-Saving Lipid Extraction from Wet Euglena gracilis by the Low-Boiling-Point Solvent Dimethyl Ether (2015)

We tested a wet extraction method for lipid extraction from Euglena gracilis water slurry at 0.51 MPa and 20 °C using liquefied dimethyl ether (DME). The yields, proximate analyses, elemental composition, and molecular weight distribution properties of the extracts from E. gracilis and the remaining residues obtained by DME extraction were compared with those of the extracts obtained by hexane Soxhlet extraction.
Keyword Search using Modified Minimum Edit Distance Measure (2007)

A popular approach for keyword search in speech files is the phone lattice search. Recently minimum edit distance (MED) has been used as a measure of similarity between strings rather than using simple string matching while searching the phone lattice for the keyword. In this paper, we propose a variation of the MED, where the substitution penalties are automatically derived from the phone confusion matrix of the recognizer, as compared to heuristic or class based penalties used earlier. The results show that the substitution penalties derived from the phone confusion matrix lead to a considerable improvement in the accuracy of the keyword search algorithm.
Pathway-specific differences between tumor cell lines and normal and tumor tissue cells (2006)

Significantly altered genes in tumors compared to normal tissue were largely tissue specific. Among these genes downregulation was a major trend. In contrast, cell lines contained large sets of significantly upregulated genes that were common to multiple tissue types. Pathway upregulation in cell lines was most pronounced over metabolic pathways including cell nucleotide metabolism and oxidative phosphorylation. Signaling pathways involved in adhesion and communication of cultured cancer cells were downregulated. The three way pathways comparison presented in this study brings light into the differences in the use of cellular pathways by tumor cells and cancer cell lines.
Magnetic properties of single crystal Co2MnGe Heusler alloy films (2000)

Single crystal Co2MnGe Heusler alloy films were epitaxially grown on GaAs substrates by molecular beam epitaxy. The films have the bulk L21 crystal structure as determined by reflection high energy electron diffraction patterns and x-ray diffraction. A high saturation moment of 1006 emu/cm3 at room temperature has been measured. Ferromagnetic resonance of these ordered alloy films shows narrow linewidths and a small anisotropy. A room temperature resistivity of 115 μΩ cm and a 0.11% anisotropic magnetoresistance has also been determined.
The effects of cyclophosphamide alone and in combination with ascorbic acid against murine ascites Dalton′s lymphoma (2006)

<b>Objective</b> : To evaluate the therapeutic activity of cyclophosphamide alone and in combination with ascorbic acid against murine ascites Dalton's lymphoma.<br><b> Materials and Methods:</b> Cyclophosphamide (CP) is an anticancer drug with immunosuppressive activity, while ascorbic acid (AA) is an antioxidant. Ascites Dalton's lymphoma (DL) was maintained by intraperitoneal (i.p.) transplantation of tumor cells in Swiss albino mice. Tumor transplanted mice were divided into four groups. Group-I mice received normal saline only and served as control. Group-II mice were given 1% ascorbic acid through drinking water from the 5th to the 10th day. Group-III mice were injected i.p. with a single dose of CP (200 mg/kg) on the 10th day of tumor transplantation. Group IV mice received 1% ascorbic acid from the 5th day onwards and, then, a single dose of CP, i.p., on the 10th day of tumor transplantation. In groups III and IV, after 24, 48, 72, and 96 h of CP treatment the liver, kidneys, spleen, and tumor tissue were collected for biochemical determinations. In group II, which received AA only from the 5th to the 10th day, the same tissues were collected on the 10th day of tumor transplantation. The changes in reduced glutathione (GSH) and carbohydrate in tumor cells as well as the liver, kidney, and spleen of tumor-bearing mice in relation to the antitumor activity of CP alone or in combination with AA were evaluated. The quantitative changes in sialic acid level of DL cells under these treatment conditions were also determined. <b> <br>Results:</b> AA and CP combination in tumor-bearing mice was found to be more effective against DL as it caused a 257% increase in life span compared with control, while it was 106% with AA and 188% with CP alone (ANOVA, P<u> <</u> 0.001). The reduced glutathione (GSH) level increased in DL cells with tumor growth. Compared with CP alone, the combination treatment (AA + CP) resulted in a more pronounced effect causing decreases in non-protein thiol (NPSH) as well as sialic acid levels in DL cells (ANOVA, P<u> <</u> 0.001).<br><b> Conclusion:</b> The drug-mediated lowering of GSH levels in DL cells may be involved in the cytotoxicity due to CP (group-III) as well as AA + CP combination (group-IV). An overall decrease in the sialic acid content of DL cells after combination treatment may also play a role to bring about alterations in the tumor cells, cell-cell interaction and enhanced tumor regression.
Improved video categorization from text metadata and user comments (2011)

We consider the task of assigning categories (e.g., howto/cooking, sports/basketball, pet/dogs) to YouTube videos from video and text signals. We show that two complementary views on the data -- from the video and text perspectives -- complement each other and refine predictions. The contributions of the paper are threefold: (1) we show that a text-based classifier trained on imperfect predictions of the weakly supervised video content-based classifier is not redundant; (2) we demonstrate that a simple model which combines the predictions made by the two classifiers outperforms each of them taken independently; (3) we analyse such sources of text information as video title, description, user tags and viewers' comments and show that each of them provides valuable clues to the topic of the video.
<i>Cronología herediana (1803-1839)</i> , por F. González del Valle (1940)

alucinante" mis parece' bosquejo de novela que novela crta ni cuent, lo cual se deber al hecho de que la dej indita la escritora. El tema central es el efecto de una idea fija, concebida cuando era nio el, protagonista-Gastn, sobre la vida y el carcter de ste. Se repite la ,idea a intervalos por medio del estribillo "Eres otro", hasta que, a fuerza de tanta repeticin por distintas personas y del consigiuiente creerlo Gastn, llega a parecer una especie de Doppelganger literario que estorba, por su mera existencia as como por sus escritos, la carrera del protagonista en
Experimental Investigation on Edge Inversion at Trivalent Bismuth and Antimony: Great Acceleration by Intra- and Intermolecular Nucleophilic Coordination (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExperimental Investigation on Edge Inversion at Trivalent Bismuth and Antimony: Great Acceleration by Intra- and Intermolecular Nucleophilic CoordinationYohsuke Yamamoto, Xiang Chen, Satoshi Kojima, Keisuke Ohdoi, Mutsuko Kitano, Yasutaka Doi, and Kin-ya AkibaCite this: J. Am. Chem. Soc. 1995, 117, 14, 3922–3932Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/ja00119a005https://doi.org/10.1021/ja00119a005research-articleACS PublicationsRequest reuse permissionsArticle Views1035Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
View Matching with Blob Features (2005)

This paper introduces a new region based feature for object recognition and image matching. In contrast to many other region based features, this one makes use of colour in the feature extraction stage. We perform experiments on the repeatability rate of the features across scale and inclination angle changes, and show that avoiding to merge regions connected by only a few pixels improves the repeatability. Finally we introduce two voting schemes that allow us to find correspondences automatically, and compare them with respect to the number of valid correspondences they give, and their inlier ratios.
Successful Aging (1997)

Substantial increases in the relative and absolute number of older persons in our society pose a challenge for biology, social and behavioral science, and medicine. Successful aging is multidimensional, encompassing the avoidance of disease and disability, the maintenance of high physical and cognitive function, and sustained engagement in social and productive activities. Research has identified factors predictive of success in these critical domains. The stage is set for intervention studies to enhance the proportion of our population aging successfully.
‘2010 개혁주의생명신학 선언문``의 선교적 의미 (2011)

본 논문은 2010년 장종현 박사가 주창한 “개혁주의생명신학 선언문”은 한국 교회의 신학적 반성에 대한 촉구를 골자로 하는 내용으로 장종현 박사의 신학적 정체성일 뿐만 아니라 이를 통해 한국 교회와 함께 신학교라는 두 축을 움직이는 두 축이다. 이로 인해 백석학원은 학교의 높은 위상에 자부심을 갖게 됐다. 본 논문에서는 개혁주의생명신학에 대한 용어의 문제이기 보다는 태도와 마음가짐에 집중하였다. 이러한 상황에서 본 연구자는 개혁주의생명신학의 한국 사회와 교회의 상황에서 필연적인 의미를 갖는 당위성을 견지해야 한다는 전제하에 2010년 개혁주의생명신학 선언문의 선언동기와 선언문 내용에 포함되어 있는 선교적 함의를 고찰하고, 선교적 차원에서 실행하기 위한 실천방안을 논의하고자 한다. 장종현 박사는 “신학은 학문이 아니다”라는 선언을 함과 동시에“개혁주의생명신학”만이 한국 교회의 회복, 신학을 회복할 수 있다는 믿음아래 “절망적인 신학교와 교회에서 희망을 버리지 않고 끊임없이 꿈을 향해 정진”해 왔다. 장종현박사는 “개혁주의생명신학”을 통하여 한국 교회와 신학의 회복을 위한 희망을 찾으려 한다. 그는 항상 “작고 느리고 섬세하게” 희망을 찾는 바른 생활상(Right Livelihood Awards)을 외치고 있다. 이는 개혁주의생명신학을 주창하게 된 동기 즉 “다른 신학을 주장하는 것이 아니라 죽어 있는 개혁신학을 살려야 한다. 장종현 박사는 개혁주의생명신학의 실천적 운동을 활발히 전개하기 위해 선언문에 일곱 가지 운동 즉 신앙운동, 신학회복운동, 영적생명운동, 하나님 나라운동, 기도운동, 성령운동, 그리고 나눔운동을 주장 한다. 결과적으로 개혁주의의 가장 근본적인 주장인 “성경대로 돌아가서 성경이 말씀하는 대로 믿고 성경이 말씀하는 대로 사는 것이 죽어버린 신학을 살리는 길”이다. 이것이 개혁주의생명신학 운동의 핵심 내용이다. 개혁주의생명신학은 기독교대학으로서 정체성을 견고히 하는 원동력이며, 학교가 지향해야 할 근본적인 목표이다. 즉 기독교대학의 근본은 ``예수 그리스도를 통한 영원한 생명을 얻도록``하는 것이다. 이것은 모든 기독교대학이 영생의 신학 곧 생명신학의 토대위에 세워져야 함을 의미한다고 볼 수 있다. 그리고 개혁주의생명신학 선언문을 발표하게 된 동기의 핵심은 교회의 발전을 통한 하나님 나라 확산과 선교적사명 완수이다. 한국 교회의 회복과 발전을 위해 개혁주의생명신학이 주창한 7대 운동은 “신앙운동, 신학회복운동, 영적생명운동, 하나님 나라운동, 기도운동, 성령운동, 나눔운동”이다. 개혁주의생명신학의 교회의 올바른 회복과 발전의 동기는 이 선언문의 중심 내용 즉 “신학은 학문이 아니라 생명을 살리는 복음”이며, “교회와 세상을 변화시키는 원동력”이라는 근본취지에서도 드러난다. 2010 개혁주의생명신학 선언문``의 선교적 의미적 의미는 한국 교회위기의 돌파구의 핵심은 영이요, 첫째는, 하나님의 말씀 회복이다. 모든 주의 백성들이 하나님의 말씀을 듣고, 주 안에서 누릴 때 교회의 위기 돌파구가 보이게 될 것이다. 둘째는, 영적 생명력 회복이다. 장종현박사의 “생명의 말씀”은 교회와 세상을 살리는 원동력이란 의미다. 이러한 주장은 예수 그리스도의 지상명령 즉 대위임령(마 28:18-20)과 예수그리스도의 복음을 땅 끝까지(행 1:8)전하라는 명령과 일치한다. 셋째는, 선교 활성화 및 운동이다. 장종현 박사는 계속해서 “개혁주의신학의 핵심인 하나님이 주시는 영적 생명을 놓치고, 이론 중심의 신학연구에 머무르는 것을 보며 안타까운 마음을 금할 길이 없다”고 표현하며 개혁주의생명신학 운동을 활발히 전개하기 위해 7대 운동을 펼치게 되었음을 밝히고 있다. 본 논문에서 개혁주의생명신학 선언문의 선교적 실천방안에 대하여 다음과 같이 역설하였다. 첫째는, 생명에 들어가기 위한 말씀(계명) 지키기이다. 둘째는, 영적인 사람, 생명의 사람으로 살기이다. 셋째는, 사역의 감각성을 지닌 지도자 양성이다. 넷째는, 순수한 복음을 성경말씀대로 선포하여 교회의 생명력 회복이다. 개혁주의생명신학 선언문의 7대 운동의 전반적인 내용은 복음전도의 목적이 담겨 있다. 7대 운동은 “이 땅에서의 예수 그리스도의 삶에 관한 지식을 계속 보존하는것, 그리고 그분의 재림을 위해 준비하는 것, 그분이 사람들의 마음 문앞에서 두드리고 그들 속으로 들어가려고 함”을 강조하고 있다.
The streptococcal IgG degrading enzyme IdeS - studies on host-pathogen interactions (2012)

The important human pathogen Streptococcus pyogenes causes both mild infections such as pharyngitis and impetigo but also severe life threatening invasive infections.  Specific antibodies (IgG) rec ...
Optimization Techniques for Two-Dimensional Placement (1984)

Present VLSI synthesis programs typically characterized as silicon compilers employ a predefined floorplan and fixed placement of functional elements. Significant broadening of the areas of application and more effective utilization of silicon space can be obtained by using a general placement of functionally clustered elements rather than a fixed floorplan. In this paper we present a new mathematical optimization technique to achieve a two-dimensional placement. The two-dimensional placement problem is the most important part of the hierarchical placement approach being considered by GTE Laboratories for its SilC Silicon Compiler. This paper describes a method of solving the placement problem in a mathematical form and an algorithm for optimization. The construction of a mathematical model and the use of optimization techniques represent the main distinction from heuristic placement procedures. The optimization technique guarantees a feasible placement at each iteration. It is also possible to determine at each stage how close the solution is to the optimum, and therefore the process may be stopped when the result is sufficiently close to optimum. A small, illustrative example of a two-dimensional placement problem was considered.
Mixed analog-digital multirate signal processing (1996)

To achieve higher levels of integration there has been a growing interest in recent years in designing systems containing both analog and digital functions on a single integrated circuit. In most cases, these are inherently multirate systems because of the different sampling rates employed at various stages of the system. This paper reviews some recent developments in this area of integrated multirate analog-digital systems, with a special emphasis on their applications to communication systems.
Osteoporosis management. (1992)

About 40% of women who reach the age of 50 are expected to suffer from osteoporosis during their remaining life. The morbidity associated with hip, spinal and wrist fractures, resulting from osteoporosis, and the mortality resulting from hip fractures justify the development of prevention strategies. Optimal management of osteoporosis consists of maximizing peak bone mass in early adulthood and preventing the rapid bone loss that occurs soon after the menopause. Peak bone mass will be reached in most women if adequate nutrition is taken and exercise is encouraged, while major risk factors are avoided. At the menopause, prescription of hormone replacement therapy (HRT) constitutes the primary prevention strategy. There are, however, questions that remain unanswered or debated. What is the optimal dose of HRT, when should it be started, and for how long should it be maintained? In women who do not, or may not, take HRT, and who have osteoporosis, alternative therapeutic options include diphosphonates (e.g., alendronate) and Selective Estrogen Receptor Modulators (such as raloxifene). Other treatments to restore bone strength in women with established disease may also reduce the risk of fractures. Some of them, such as calcitonin, may not be cost effective. Others have produced conflicting data (fluoride) and others are still under evaluation (PTH or strontium). In sunlight-deprived, vitamin D-deficient elderly nursing home residents, dietary supplementation of calcium and vitamin D has been shown to prevent bone loss and fractures. Strategies to avoid falls should also be encouraged for these patients.
Stress-Induced p38 Mitogen-Activated Protein Kinase Activation Mediates κ-Opioid-Dependent Dysphoria (2007)

The molecular mechanisms mediating stress-induced dysphoria in humans and conditioned place aversion in rodents are unknown. Here, we show that repeated swim stress caused activation of both kappa-opioid receptor (KOR) and p38 mitogen-activated protein kinase (MAPK) coexpressed in GABAergic neurons in the nucleus accumbens, cortex, and hippocampus. Sites of activation were visualized using phosphoselective antibodies against activated kappa receptors (KOR-P) and against phospho-p38 MAPK. Surprisingly, the increase in P-p38-IR caused by swim-stress exposure was completely KOR dependent; P-p38-IR did not increase in KOR(-/-) knock-out mice subjected to the same swim-paradigm or in wild-type mice pretreated with the KOR antagonist norbinaltorphimine. To understand the relationship between p38 activation and the behavioral effects after KOR activation, we administered the p38 inhibitor SB203580 [4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)-1H-imidazole (i.c.v.)] and found that it selectively blocked the conditioned place aversion caused by the kappa agonist trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide (U50488) and the KOR-dependent swim stress-induced immobility while not affecting kappa-opioid analgesia or nonselectively affecting associative learning. We found that the mechanism linking KOR and p38 activation in vivo was consistent with our previous in vitro data suggesting that beta-arrestin recruitment is required; mice lacking G-protein-coupled receptor kinase 3 also failed to increase p-p38-IR after KOR activation in vivo, failed to show swim stress-induced immobility, or develop conditioned place aversion to U50488. Our results indicate that activation of p38 MAPK signaling by the endogenous dynorphin-kappa-opioid system likely constitutes a key component of the molecular mechanisms mediating the aversive properties of stress.
Design and evaluation of multi agent systems for rescue operations (2004)

The activities of search and rescue of victims in large-scale disasters are very relevant social problems, and from a scientific viewpoint raise many different technical problems in the fields of artificial intelligence, robotics and multi agent systems. In this paper we describe the development of a multi agent system based on the RoboCup Rescue simulator to allow monitoring and decision support, that are needed in a rescue operation. Two significant accomplishments are reported in this paper: the first is a framework for cognitive agent development that provides for the capabilities of information fusion, planning and coordination; the second one is a methodology for evaluation of multi-agent systems in this scenario that aims at measuring not only the efficiency of a system, but also its robustness when conditions in the environment change.
Spherical microphone arrays for analysis of sound fields in buildings (2006)

The features and applications of various beamforming microphone arrays, are discussed. 'Open' or 'free field' array has a diameter of 16 cm in which 32 omnidirectional electret microphones (6 mm diameter) lie on the surface of sphere. Free field array can be used for analysis of isotropy of sound fields in rooms and detection of sound leaks in walls including directions of incidence or reflections of sound waves. In the detection of sound leaks in walls, the wall contains a pair of back-to-back electrical boxes which causes increased levels at the array position arriving from their direction and boxes cause a sound leak in the wall which is detected by the array. A 10 cm diameter rigid array that contain 32 omnidirectional electret microphones (6 mm diameter) flush mounted in the surface of a hollow aluminum sphere, has the capability of smooth the white noise gain to improve the noise tolerance.
Control and Monitoring of Concurrent Design Tasks in a Dynamic Environment (2004)

In product development, it is common for concurrent design tasks to be coupled, and, because of complex information flows, to iterate several times before the entire product development process is completed, leading to delays in product launches and cost overruns. Furthermore, unexpected disturbances may destabilize the entire product development process. A generalized homogeneous and non-homogeneous state-space concept is proposed to model concurrent, coupled design tasks and to analyze and control the stability and convergence rate of the design tasks. The homogeneous analysis predicts the number of design iterations before the design tasks are completed and identifies those tasks that consume a disproportionate amount of resources and time to complete. The non-homogeneous analysis precisely monitors and controls the stability and the convergence rate of the concurrent design tasks through state feedback control. A case study of a camera design is discussed to illustrate how the convergence rate of the tasks can be improved and initial instability of tasks is managed. The proposed methodology can facilitate workload distribution and resource allocation in design task planning and management in the face of unexpected disturbances.
MOTIVACIÓN LABORAL Y GESTIÓN DE RECURSOS HUMANOS EN LA TEORÍA DE FREDERICK HERZBERG (2005)

En la búsqueda de la competitividad empresarial en la Nueva Economía y Management los administradores deben diseñar estilos de liderazgo y practicas administrativas de alta eficiencia y desempeño de los recursos humanos. La complejidad de la motivación laboral requiere de enfoques que tomen en cuenta los factores personales y ambientales. La discusión de los aportes de un pensador pionero en el tema como Frederick Herzberg y la interpretación de un trabajo de tesis de maestría de nuestra Facultad de Ciencias administrativas titulado ; «Diseño y validación de un modelo para la identificación y medición de los factores motivacionales de los trabajadores según la teoría de F. Herzberg,» son las motivaciones de este trabajo reflexivo. La practica y las investigaciones modernas de la administración señalan a la motivación como factor clave que los gerentes incorporan en las relaciones de trabajo que crean y supervisan. La función administrativa de la Dirección se entiende, como el proceso de influir en la gente, para que contribuya a los objetivos de los individuos y de la organización en conjunto; para esto se requiere la creación y el mantenimiento de un contexto en el que los individuos trabajen juntos en grupos hacia el logro de objetivos comunes.