gebhart/patrepeval huggingface dataset:
Self‐assembly of peptide nanotubes and amyloid‐like structures by charged‐termini‐capped diphenylalanine peptide analogues (2005)

Abstract We had recently demonstrated that the diphenylalanine peptide, the core recognition motif of the Alzheimer's ß‐amyloid polypeptide, self‐assembles into a novel class of peptide nanotubes. The formation of well‐ordered supramolecular structures at the nanoscale by such a simple peptide was consistent with our suggestion that aromatic interactions may provide order and directionality needed for the formation of fibrillar peptide structures. Yet, we could not rule out a contribution of the charged amine and carboxyl moieties at the termini of the short peptide. In order to explore the potential role of electrostatic interaction in the assembly process we have studied a modified non‐charged peptide analogue, Ac‐Phe–Phe‐NH 2 , in which the N‐terminal amine was acetylated and the C‐terminal carboxyl was amidated. Scanning and transmission electron microscopy analyses demonstrated that this peptide analogue self‐assembles into highly‐ordered tubular structures, as observed with the NH 2 ‐Phe–Phe‐COOH. Also, infrared spectroscopy revealed an amide I absorbance pattern that is very similar to that of the non‐modified peptide. Furthermore, an amidated NH 2 ‐Phe–Phe‐NH 2 peptide, which has a net positive charge, also self‐assembled into ordered tubular structures. On the other hand, the amine‐modified analogues Boc‐Phe–Phe‐COOH, Z‐Phe–Phe‐COOH, and Fmoc‐Phe–Phe‐COOH peptides formed amyloid‐like structures that had a significantly smaller diameter. Taken together, the current study further supports our hypothesis regarding the role of aromatic interactions in the self‐assembly of amyloid fibrils and amyloid‐associated nanostructures that can be modulated by simple chemical modifications.
Versatile method for optical performances characterization of off-axis CMOS pixels with microlens radial shift (2008)

In this paper, we present a versatile characterization method we developed at STMicroelectronics for off-axis pixels (i.e. over the image plane) on CMOS image sensor. The solution does not require optics, making it suitable for early design phases as for optimizations and investigations. It is based on a specific design of color filters and microlens masks, which consists in several blocks. Inside each block, the filters and the microlens are shifted by a given amount, relatively to the pixel. Each block is related to a given chief ray and then defines a point in the chief ray angle space. Then, the performances of these angular points can be measured by rotating the sensor, using conventional uniform illumination setup with controlled f-number. Then it is possible to map these data on the image plane, knowing the chief ray angle versus focal plane coordinate function. Finally, we present some characterizations and optimizations based on the fact that the shift is arbitrary defined during circuit layout step, so it is possible to test the sensor with higher chief ray angles than those present in the product, or to optimize the shift of the microlens versus the chief ray angle for a given pixel architecture.
Statutes and the E.E.C.—Interim Relief and the Crown (1989)

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Translation among WYSIWYG word processors in Chameleon (1988)

There is a need for widespread exchange of electronic documents in domains as diverse as book publishing, automated offices, factories, and research laboratories. The broad variety of data representations, particularly data created by wysiwyg word processors, is an obstacle to this exchange. This paper describes how the Chameleon translation-generation system accommodates this class of electronic documents. A comparison to an existing commercial product, with similar functionality, is also presented.
HIF‐1 is expressed in normoxic tissue and displays an organ‐specific regulation under systemic hypoxia (2001)

Adaptation to hypoxia is regulated by hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor consisting of an oxygen-regulated alpha subunit and a constitutively expressed beta subunit. Although HIF-1 is regulated mainly by oxygen tension through the oxygen-dependent degradation of its alpha subunit, in vitro it can also be modulated by cytokines, hormones and genetic alterations. To investigate HIF-1 activation in vivo, we determined the spatial and temporal distribution of HIF-1 in healthy mice subjected to varying fractions of inspiratory oxygen. Immunohistochemical examination of brain, kidney, liver, heart, and skeletal muscle revealed that HIF-1alpha is present in mice kept under normoxic conditions and is further increased in response to systemic hypoxia. Moreover, immunoblot analysis showed that the kinetics of HIF-1alpha expression varies among different organs. In liver and kidney, HIF-1alpha reaches maximal levels after 1 h and gradually decreases to baseline levels after 4 h of continuous hypoxia. In the brain, however, HIF-1alpha is maximally expressed after 5 h and declines to basal levels by 12 h. Whereas HIF-1beta is constitutively expressed in brain and kidney nuclear extracts, its hepatic expression increases concomitantly with HIF-1alpha. Overall, HIF-1alpha expression in normoxic mice suggests that HIF-1 has an important role in tissue homeostasis.
Azidation of Silicon(111) Surfaces (2008)

A two-step chlorination/azidation process was reported to prepare azide-modified silicon(111) surfaces. XPS and IR analyses show the covalent bonding of azide with silicon. In combination with scanning tunneling microscopy and spectroscopy analyses, different kinetic rates, azide coverages, and surface-area distributions were derived depending on the azidation solvent.
Mode selection and resource allocation for device-to-device communications in 5G cellular networks (2016)

To meet the increasing demand of wireless broadband applications in future 5G cellular networks, Device-to-Device (D2D) communications serve as a candidate paradigm to improve spectrum efficiency. Considering the challenges after D2D transmission is introduced for future cellular networks, this paper deals with mode selection and resource allocation issues related with D2D communications. First, we propose a mode selection scheme which aims at guaranteeing the transmission of cellular users and also considering the potential interference. We analyze the condition under which D2D underlay mode should be used. Second, we answer the question of “how to effectively reuse cellular resource once underlaying mode is adopted”. We further present a resource allocation scheme that focuses on minimizing overall interference as well as a power control method to improve the performance of D2D systems. Simulation results demonstrate that system parameters greatly affect the switching condition of mode selection and probability of choosing underlay mode. Furthermore, for D2D underlaying scenario, the proposed resource allocation algorithm guarantees the transmission of cellular users with consideration of transmission requirements of D2D users. Hence, the proposed scheme can achieve better user experience.
High Transparency Infrared MaterialsÃÂ¢ÃÂ (1976)

The period 1970-1975 has been one of unusual activity in the field of infrared materials. Driven primarily by the need for highly transparent lens and window elements in high power laser optics, significant advances have been made in the quality, physical strength and size of a variety of materials and in particular the alkali halides, alkaline earth fluorides, zinc selenide, and for use in fiber optics, fused silica. The state-of-the-art of these materials is outlined, the basic physical processes that determine their optical and mechanical limits are reviewed, and suggestions are made for future work in electro-optic and magneto-optic materials research.
Phase II Study of Neoadjuvant Imatinib in Glioblastoma: Evaluation of Clinical and Molecular Effects of the Treatment (2009)

Intact imatinib was detected in glioblastoma multiforme tissue. However, the histologic and immunoblotting evaluations suggest that glioblastoma multiforme proliferation and survival mechanisms are not substantially reduced by imatinib therapy in most patients.
Solution Structure of the N-Terminal EGF-like Domain from Human Factor VII<sup>,</sup> (1998)

Blood coagulation is initiated by Ca(2+)-dependent binding of coagulation factor VIIa (FVIIa) to its cofactor, tissue factor (TF). The TF:FVIIa complex activates factors IX and X, ultimately leading to the formation of thrombin and the coagulation of blood. FVII consists of an N-terminal gamma-carboxyglutamic-acid-containing (Gla) domain followed by two epidermal growth factor (EGF) like domains, the first of which can bind one Ca2+ ion (Kd approximately 150 microM) and a C-terminal serine protease domain. Using 1H nuclear magnetic resonance spectroscopy, we have determined the solution structure of a synthetic N-terminal EGF-like domain (EGF1) of human FVII (residues 45-85) in the absence of Ca2+. A comparison of this structure of apo EGF1 with the Ca(2+)-bound EGF1 in the complex of FVIIa and TF [Banner, D. W., et al. (1996) Nature 380, 41-46] suggests that the structural changes in the EGF1 domain upon Ca2+ binding are minor and are concentrated near the Ca(2+)-binding site, which is facing away from the TF interaction surface. Amino acid side chains that are crucial for the binding of FVII to TF show a similar conformation in both structures and are therefore unlikely to directly influence the Ca(2+)-dependent binding of FVII to TF. As Ca2+ binding to EGF1 does not lead to a conformational change in the residues constituting the interaction surface for binding to TF, our results are consistent with the idea that the altered orientation between the Gla and EGF1 domains that result from Ca2+ binding is responsible for the increased affinity of FVII/FVIIa for TF.
Molecular cloning and the complete nucleotide sequence of cDNA to mRNA for S-100 protein of rat brain (1984)

The complete nucleotide sequence of mRNA for beta-subunit of rat brain S-100 protein was determined from recombinant cDNA clones. The sequence was composed of 1488 bp which included the 276 bp of the complete coding region, the 120 bp of the 5'-noncoding region and the 1092 bp of the 3'-noncoding region containing two polyadenylation signals. In addition, the poly(A) tail was also found. The amino acid sequence deduced from the nucleotide sequence was homologous to the amino acid sequence of bovine S-100 beta subunit except 4 residues showing species differences. From the viewpoint of evolutionary implications, the homology between the nucleotide sequence of S-100 and those of rat intestinal Ca-binding protein (ICaBP) and calmodulin (CaM) was examined. A dot-blot hybridization of poly(A) RNA from the developing rat brains using a labeled cDNA showed a rapid increase in S-100 mRNA at 10-20 postnatal days. The presence of S-100 mRNA in C-6 glioma cells is also described.
Restoration Of Video By Removing Rain (2012)

The objective is to remove rain from videos without blurring the object. The algorithm helps to devise the system which removes rain from videos to facilitate video surveillance, and to improve the various visionbased algorithms. Rain is a noise that impairs videos and images. Such weather conditions will affect stereo correspondence, feature detection, segmentation, and object tracking and recognition. In video surveillance if any problem is found due to weather conditions the object cannot be tracked well. In this paper we have considered only rain falling in static environment, i.e., the object is not moving.
Thermotropic phase transitions in the bidimensional compound (C<sub>10</sub>H<sub>21</sub>NH<sub>3</sub>)<sub>2</sub>Cucl<sub>4</sub> (1993)

The structural phase transitions in crystalline (n-C10H21NH3)2CuCl4 have been investigated by X-ray diffraction, IR spectroscopy and differential scanning calorimetry. The compound shows stepwise phase transitions with hysteresis, the heating and cooling cycles comprising three and four steps, respectively. Thus five phases are defined: [math]. The proposedmechanism of conformational transition for this compound is
Effectiveness of Erosion Control Blankets on Reducing Shear Stress Acting on Soil Particles (2013)

A dominant factor for soil detachment by surface runoff is bed shear. Erosion control blankets partition thetotal shear stress into one component acting on the blanket and the remainder on the soil particles. The fractionacting on the particles is responsible for particle detachment. In this study, a Minnesotas category III strawblanket was evaluated in a laboratory flume. Particle shear was measured using hot-film anemometry techniquesand total shear was estimated from channel flow parameters. The blanket was secured using two differentfastening scenarios. The slope of the flume was set at 1%. Flow rates ranged from 1.3 L/s to 23.4 L/s. Overthis range of flow conditions, particle shear stress ranged from 2.7% to 13.2% of the total shear stress.
Heat pipes applied to flat-plate solar collectors. Final report (1976)

The objective of this program was to analytically and experimentally investigate the use of heat pipes in flat-plate solar collectors. Heat pipes are passive heat transport devices which utilize a closed evaporation-condensation cycle. Because of their high equivalent conductance, they appear to be well suited to transport heat from the solar absorber to an air or liquid distribution system. The program consisted of the following tasks: (I) Configuration Studies, (II) Parametric Performance Studies, (III) Economic Analysis, (IV) System Integration Studies, (V) Submodule Fabrication and Testing (in the laboratory), and (VI) Full-Scale Module Fabrication and Testing (using solar input). An additional Task VII, Feasibility Study of a Stationary Concentrator, was identified during the program and was also completed. In performing Tasks I through IV, various aspects of integrating heat pipes into flat-palte solar collectors were investigated. The results of these tasks were reported in the Annual Progress Report (Ref. 2) dated January 31, 1975. A summary of that program effort is included in the present report. The results of the experimental work conducted under Tasks V and VI are presented in this report. Under Task V, breadboard heat pipes were fabricated from sections of Roll-Bond panels and their heat transfer performance was evaluated in the laboratory. Three complete solar panels, two of which were heat pipe absorbers and one was a Roll-Bond control panel, were fabricated and solar tested during Task VI. Finally, under the new Task VII, a feasibility study of a stationary concentrator using heat pipes as thermal diodes was conducted. Results are presented and discussed.
First results from the DarkSide-50 dark matter experiment at Laboratori Nazionali del Gran Sasso (2015)

We report the first results of DarkSide-50, a direct search for dark matter operating in the underground Laboratori Nazionali del Gran Sasso (LNGS) and searching for the rare nuclear recoils possibly induced by weakly interacting massive particles (WIMPs). The dark matter detector is a Liquid Argon Time Projection Chamber with a (46.4 0.7) kg active mass, operated inside a 30 t organic liquid scintillator neutron veto, which is in turn installed at the center of a 1 kt water Cherenkov veto for the residual flux of cosmic rays. We report here the null results of a dark matter search for a (1422 67) kg d exposure with an atmospheric argon fill. This is the most sensitive dark matter search performed with an argon target, corresponding to a 90% CL upper limit on the WIMP-nucleon spin-independent cross section of 6.1 10 -44 cm 2 for a WIMP mass of 100 Gev/c 2 .
Another mutation that results in the substitution of an unpaired cysteine residue in the extracellular domain of FGFR3 in thanatophoric dysplasia type I (1995)

Journal Article Another mutation that results in the substitution of an unpaired cysteine residue in the extracellular domain of FGFR3 in thanatophoric dysplasia type I Get access Patricia L. Tavormina, Patricia L. Tavormina Department of Biological Chemistry, University of CaliforniaIrvine, CA 92717 Search for other works by this author on: Oxford Academic PubMed Google Scholar David L. Rimoin, David L. Rimoin 1Cedars-Sinai Research Institute and Department of Pediatrics, UCLA School of MedicineLos Angeles, CA 90048, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Daniel H. Cohn, Daniel H. Cohn 1Cedars-Sinai Research Institute and Department of Pediatrics, UCLA School of MedicineLos Angeles, CA 90048, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Ya-Zhen Zhu, Ya-Zhen Zhu Department of Biological Chemistry, University of CaliforniaIrvine, CA 92717 Search for other works by this author on: Oxford Academic PubMed Google Scholar Rita Shiang, Rita Shiang Department of Biological Chemistry, University of CaliforniaIrvine, CA 92717 Search for other works by this author on: Oxford Academic PubMed Google Scholar John J. Wasmuth John J. Wasmuth * Department of Biological Chemistry, University of CaliforniaIrvine, CA 92717 *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Molecular Genetics, Volume 4, Issue 11, November 1995, Pages 2175–2177, https://doi.org/10.1093/hmg/4.11.2175 Published: 01 November 1995 Article history Received: 09 May 1995 Revision received: 11 August 1995 Accepted: 11 August 1995 Published: 01 November 1995
Treatment with apo B peptide vaccines inhibits atherosclerosis in human apo B‐100 transgenic mice without inducing an increase in peptide‐specific antibodies (2008)

Immunization with apo B peptide-based vaccines inhibits atherosclerosis in mice expressing human apo B-100 suggesting that they can interact with their target as expressed in humans. The protective effect is independent of the pre-existing level of apo B peptide autoantibodies and can occur without activating an increase in peptide-specific antibodies suggesting that atheroprotection can be mediated by cellular immune responses.
Amine Boranes. I. The Preparation of Pyridine Arylboranes (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmine Boranes. I. The Preparation of Pyridine ArylboranesM. Frederick HawthorneCite this: J. Am. Chem. Soc. 1958, 80, 16, 4291–4293Publication Date (Print):August 1, 1958Publication History Published online1 May 2002Published inissue 1 August 1958https://pubs.acs.org/doi/10.1021/ja01549a043https://doi.org/10.1021/ja01549a043research-articleACS PublicationsRequest reuse permissionsArticle Views709Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The copolymerization behavior of acrylate dimers: Copolymers of methyl, ethyl, and <i>n</i>‐butyl acrylate dimers (1991)

Abstract Dimers of methyl, ethyl, and n ‐butyl acrylate were synthesized in good yield through the use of a phosphine catalyst. The dimers synthesized in this manner have one double bond. The activity of this double bond was investigated in copolymerization reactions with styrene. The methyl acrylate dimer proved to have a slightly more favorable reactivity ratio than either the ethyl or n ‐butyl acrylate dimers.
Add-ons in IVF programme - Hype or Hope? (2015)

A series of new technologies and adjuvant therapies have been advocated in order to improve the success of IVF treatment. Dehydro-epiandrostenedione, growth hormones, Coenzyme Q 10, calcium ionosphores, immune therapy, heparin, low-dose aspirin, and vasodilators are among commonly prescribed pharmacological adjuvants. New technologies that are proposed to improve IVF outcomes include advanced sperm selection procedures, time- lapse embryo monitoring, preimplantation genetic screening, assisted hatching endometrial injury or embryo-glue. This review looked into current evidence to justify the use of these co-interventions and whether some of them can still be offered while awaiting more robust evidence to con rm or refute their role.
Comparison of Fluorescent Brightening in the Production of Synthetic‐polymer Fibres and in the Textile Industry (1971)

The different methods of mass brightening synthetic‐polymer fibres are briefly surveyed. The physical and chemical characteristics of fluorescent brighteners (FBA) for polyester and nylon fibres, both for incorporation in the mass and for conventional application during the processing of textiles, are discussed. Various methods of application for selected FBA are compared with respect to the whitening effects and fastness properties obtained.
High-Speed Measurement of BRDF using an Ellipsoidal Mirror and a Projector (2007)

Measuring BRDF (bi-directional reflectance distribution function) requires huge amounts of time because a target object must be illuminated from all incident angles and the reflected lights must be measured from all reflected angles. In this paper, we present a high-speed method to measure BRDFs using an ellipsoidal mirror and a projector. Our method makes it possible to change incident angles without a mechanical drive. Moreover, the omni-directional reflected lights from the object can be measured by one static camera at once. Our prototype requires only fifty minutes to measure anisotropic BRDFs, even if the lighting interval is one degree.
Las migraciones: ¿un problema "aparcado"? (2010)

Given that a subpopulation of most bacterial cells becomes dormant due to stress, and that the resting cells of pathogens can revive and reconstitute infections, it is imperative to find methods to treat dormant cells to eradicate infections. The dormant bacteria that are not spores or cysts are known as persister cells. Remarkably, in contrast to the original report that incorrectly indicated indole increases persistence, a large number of indole-related compounds have been found in the last few years that kill persister cells. Hence, in this review, along with a summary of recent results related to persister cell formation and resuscitation, we focus on the ability of indole and substituted indoles to combat the persister cells of both pathogens and non-pathogens.
A photoacoustic study of phase transition in modified strontium barium niobate ceramics (1990)

Abstract Strontium barium niobate (SBN) of the tetragonal tungsten bronze structure is a well known dielectric relaxor. In the present paper, the relaxor behavior which is a manifestation of the diffuse phase transition (DPT) characteristics is further pursued in a La-substituted SBN ceramics by the photoacoustic (PA) technique. An abrupt change of the PA signal of the pure and modified specimens shows another transition below the para-ferroelectric transition. Besides the diffuse ferroelectric phase transition the corresponding dielectric transition is located near room temperature in the modified SBN ceramics under a dc bias.