gebhart/patrepeval huggingface dataset:
Induction of measles virus‐specific cytotoxic T‐cell responses after intranasal immunization with synthetic peptides (1996)

We have investigated the structural requirements for the induction of cytotoxic T-cell responses (CTL) in vivo after intranasal immunization with an immunodominant CTL epitope from the nucleoprotein of measles virus (MV). For the induction of CTL responses, covalent linkage of the CTL epitope to a helper T-cell epitope was required and the orientation of the epitopes influenced the immunogenicity of the CTL epitope. The presence of two copies as compared with one copy of a T-helper epitope, rendered the CTL epitope more immunogenic and resulted in the in vivo induction of MV-specific CTLs without the need for an adjuvant. The role of CTL responses to this epitope in protection after intranasal administration was evaluated in a mouse model against challenge with a neuroadapted strain of MV. Although a decreased mortality in the peptide immunized compared with that in unimmunized mice was observed, the protection achieved was not significant. These findings highlight the importance of the rational design of synthetic immunogens for the induction of CTL responses and the potential of the intranasal route for immunization.
In Situ Green Synthesis of Pd Nanoparticles on Tannic Acid‐Modified Magnetite Nanoparticles as a Green Reductant and Stabilizer Agent: Its Application as a Recyclable Nanocatalyst (Fe <sub>3</sub> O <sub>4</sub> @TA/Pd) for Reduction of 4‐Nitrophenol and Suzuki Reactions (2018)

Abstract Tannic acid, as a humic‐like substance with phenolic hydroxyl and carbonyl functional groups, can modify surface of Fe 3 O 4 NPs. Moreover, it can improve surface properties and capacity of Fe 3 O 4 for adsorption and reduction of palladium ions through complexing with them, in aqueous solutions. Therefore, Fe 3 O 4 @TA NPs have potentials of reducing, stabilizing and immobilizing palladium nano particles to generate novel magnetic palladium nanocatalysts. Inductively coupled plasma (ICP), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X‐ray photoelectron spectroscopy (XPS), energy‐dispersive X‐ray spectrum (EDS), vibrating sample magnetometer (VSM) and Fourier transform infrared (FTIR) methods unraveled the catalyst properties. Investigation of Fe 3 O 4 @TA/Pd NPs performance illustrated its recycle nature and high catalytic activity towards Suzuki‐Miyaura cross‐coupling reactions and reduction of 4‐nitrophenol (4‐NP), at room temperature.
Thrombin‐induced proliferation and expression of platelet‐derived growth factor‐A chain gene in human vascular smooth muscle cells (1992)

Treatment of human vascular smooth muscle cells (SMC) with human alpha-thrombin greatly increased DNA synthesis and cell proliferation. Both the integrity of the catalytic site and that of the anion binding exosite were required for expression of this activity. Experiments employing Northerns indicated induction of c-fos expression as well as a time-dependent induction of platelet-derived growth factor-A (PDGF-A) gene by thrombin. The thrombin mitogenic activity was potentiated by PDGF-BB, insulin and the vasoconstrictor peptide endothelin-1 suggesting synergism by convergence of intracellular growth-promoting signals. SMC treatment with pertussis toxin and forskolin indicated that the mitogenic activity of thrombin may be induced via signal transduction mechanism(s) involving changes in cAMP levels and activation of a Gi-like protein. These results suggest that thrombin may play a functional role in the regulation of human vascular SMC proliferation.
The NEWT Platform: An Extensible Plugin Framework for Creating ReSTful HPC APIs (2014)

This work describes the NEWT platform, a framework for creating ReSTful web APIs for high-performance scientific computing. The NEWT platform is designed to be a customizable framework that can be deployed at an HPC center, and enables access to various backend resources and services through a common web API. The goal of this effort is to create a service that can be plugged into multiple backend resources, and can easily be extended, while presenting a standard interface to the consumer with common semantics. This effort also updates the NEWT API that has been deployed at NERSC since 2010, and provides additional structure and consistency across the API.
Phase separation in alloy-Si interaction (1980)

Phase separation has been found to be a general phenomenon among many alloy-Si interactions at temperatures as high as 800 °C. We have studied these interactions with alloys consisting of a near-noble metal of Ni, Pd, and Pt, and a refractory metal of Cr, V, and W. The interaction produces a silicide of the near-noble metals next to the Si and an outer layer of silicide of the refractory metals. No evidence for ternary formation has been found.
Role of the Nfa1 Protein in Pathogenic <i>Naegleria fowleri</i> Cocultured with CHO Target Cells (2005)

Naegleria fowleri, a free-living amoeba, exists as a virulent pathogen which causes fatal primary amoebic meningoencephalitis in experimental animals and humans. Using infected and immune mouse sera, we previously cloned an nfa1 gene from a cDNA library of N. fowleri by immunoscreening. The nfa1 gene (360 bp) produced a recombinant 13.1-kDa protein, and the Nfa1 protein showed pseudopodium-specific immunolocalization on a trophozoite of N. fowleri. In this study, the role of the Nfa1 protein as a cell contact mechanism of N. fowleri cocultured with target cells was observed by an immunofluorescence assay with an anti-Nfa1 polyclonal antibody. Using confocal microscopic findings, the Nfa1 protein was located on the pseudopodia of N. fowleri trophozoites. The Nfa1 protein in N. fowleri trophozoites cocultured with CHO target cells was also located on pseudopodia, as well as in a food cup formed as a phagocytic structure in close contact with target cells. The amount of nfa1 mRNA of N. fowleri was strongly increased 6 h after coculture.
Geologic Modeling, Upscaling and Simulation of Faulted Reservoirs Using Faulted Stratigraphic Grids (1999)

Abstract A key difficulty associated with modeling faulted reservoirs is honoring both the structure and stratigraphy while simultaneously generating models that are acceptable in terms of practical simulation run times. In this paper, we describe our approach for designing finely gridded, faulted simulation models which we then scale up using a flow based nonuniform coarsening technique that takes into account the impact of the faults. Two field examples of faulted reservoirs are presented to demonstrate the new grid design and upscaling tools and, also, to investigate the impact of faults on flow behavior. An important characteristic of our work process to generate faulted simulation models is that all of the tasks, from horizon and fault mapping to geostatistical reservoir characterization to scale up, are performed within an integrated earth modeling environment. Our grid design and scale up calculations accommodate complex fault networks and non-vertical faults (including reverse faults), although in the current implementation we allow only "logically-vertical" faults; i.e., faults with slip along the w or nominally vertical coordinate in a u, v, w stratigraphic grid. The rationale for specifying logically vertical faults is that they represent a compromise between accurately modeling fault geometry while maintaining computational efficiency when simulating flow in faulted reservoirs. Although fault geometry, which we capture with our grid design and upscaling tools, is an important component of fault transmissibility, it is not the only one. Consequently, we present a technique for modifying fault transmissibility by introducing transmissibility multipliers at fault locations in the grid. We use this technique to generate sealing faults. We then compare reservoir performance predictions based on sealing, partially communicating, and no-fault formulations. Plots of individual well performance from the field examples reveal significant differences between the three formulations.
Measurement Uncertainty Estimation in Amperometric Sensors: A Tutorial Review (2010)

This tutorial focuses on measurement uncertainty estimation in amperometric sensors (both for liquid and gas-phase measurements). The main uncertainty sources are reviewed and their contributions are discussed with relation to the principles of operation of the sensors, measurement conditions and properties of the measured samples. The discussion is illustrated by case studies based on the two major approaches for uncertainty evaluation-the ISO GUM modeling approach and the Nordtest approach. This tutorial is expected to be of interest to workers in different fields of science who use measurements with amperometric sensors and need to evaluate the uncertainty of the obtained results but are new to the concept of measurement uncertainty. The tutorial is also expected to be educative in order to make measurement results more accurate.
A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia (2011)

http://ClinicalTrials.gov number, NCT00761358.
On the Role of Analytics in Estimating the Cost of Delivering Complex Information Technology (IT) Outsourcing Services Projects (2012)

In this paper, we describe the challenges in accurately estimating the cost of delivering complex IT outsourcing services deals from an IT services provider's point of view, and we discuss how and which analytics can be employed to improve the accuracy of cost estimations. The accuracy of cost estimation is measured by the gap between the costs predicted at the time of contract signing and the actual costs incurred in delivering those solutions. Our proposed analytics are grounded in a set of observed influencing factors that are derived from our experience in developing costing tools for a large IT services provider, Also, we present a vision for building an ideal operational environment for IT service providers to achieve increased levels of visibility into their operations to improve the accuracy of their project cost estimates. To the best of our knowledge, this is the first work of its kind that articulates the issues, challenges and the role of analytics for improving the accuracy of estimating the costs of delivering complex IT outsourcing projects from IT Service Provider point of view. We hope that our work serves as a call for future research in this area. We are currently actively developing some of the analytics proposed in this paper at a large IT services provider.
Bright Visible-Infrared Light Emitting Diodes Based on Hybrid Halide Perovskite with Spiro-OMeTAD as a Hole-Injecting Layer (2015)

Hybrid halide perovskites that are currently intensively studied for photovoltaic applications, also present outstanding properties for light emission. Here, we report on the preparation of bright solid state light emitting diodes (LEDs) based on a solution-processed hybrid lead halide perovskite (Pe). In particular, we have utilized the perovskite generally described with the formula CH3NH3PbI(3-x)Cl(x) and exploited a configuration without electron or hole blocking layer in addition to the injecting layers. Compact TiO2 and Spiro-OMeTAD were used as electron and hole injecting layers, respectively. We have demonstrated a bright combined visible-infrared radiance of 7.1 W·sr(-1)·m(-2) at a current density of 232 mA·cm(-2), and a maximum external quantum efficiency (EQE) of 0.48%. The devices prepared surpass the EQE values achieved in previous reports, considering devices with just an injecting layer without any additional blocking layer. Significantly, the maximum EQE value of our devices is obtained at applied voltages as low as 2 V, with a turn-on voltage as low as the Pe band gap (V(turn-on) = 1.45 ± 0.06 V). This outstanding performance, despite the simplicity of the approach, highlights the enormous potentiality of Pe-LEDs. In addition, we present a stability study of unsealed Pe-LEDs, which demonstrates a dramatic influence of the measurement atmosphere on the performance of the devices. The decrease of the electroluminescence (EL) under continuous operation can be attributed to an increase of the non-radiative recombination pathways, rather than a degradation of the perovskite material itself.
Changes in Near Wellbore Stress and Fracture Gradient Due to Cold Water Injection in a Sirte Basin Field, Libya (2009)

Abstract It is important to understand the effects of introducing thermal changes in the subsurface because such changes alter the state of stress and, ultimately, the behavior of the formation. Inducing fractures in the formation may cause injection fluids to advance at different rates through the reservoir, thereby reducing the areal sweep through the reservoir and the overall efficiency of a flooding operation. To avoid induced fractures, it is necessary to maintain water flooding operations below the fracturing (breakdown) pressure of the formation. For these reasons, it is extremely important to model the cold water injection response and to predict whether it is possible to inject without creating fractures in the formation. In late 2006 a reservoir simulation study using ECLIPSE was performed for 103N Field in Sirte Basin to evaluate the reservoir response to water flooding in an attempt to understand the potential for improving oil and gas recovery with water flooding. This study showed that the main effect of cold water injection on the recovery of N- Field was reduced injectivity due to high water viscosity. Another effect of cold water injection was that bypassed oil was cooled down and its mobility was reduced due to the increase in the oil viscosity, thus reducing ultimate recovery. This paper provides an extension of the reservoir simulation done by Wintershall to examine the effect of cold water injection on formation fracturing gradients. The work includes a review of the rock mechanics and stress analysis of the subsurface formations and provides an estimation of fracture penetration within the reservoir for a range of water injection rates and water surface temperatures. The conclusions of this study provide important insights into applying water flooding operations in the N-field.
ONTOGENESIS OF HAEMATOPOIETIC SITES IN BRACHYDANIO RERIO (HAMILTON-BUCHANAN) (TELEOSTEI)* (1977)

The first haematopoietic sites in Brachydanio rerio are formed by the "intermediate cell mass", situated between somite and lateral plate. The sequential sites are in the endocardium, pro- and mesonephros. The results are compared with those of Pterophyllum scalare, which has its first blood anlage on the yolk sac.
Piezoresistive Sensitivity, Linearity and Resistance Time Drift of Polysilicon Nanofilms with Different Deposition Temperatures (2009)

Our previous research work indicated that highly boron doped polysilicon nanofilms (≤100 nm in thickness) have higher gauge factor (the maximum is ∼34 for 80 nm-thick films) and better temperature stability than common polysilicon films (≥ 200nm in thickness) at the same doping levels. Therefore, in order to further analyze the influence of deposition temperature on the film structure and piezoresistance performance, the piezoresistive sensitivity, piezoresistive linearity (PRL) and resistance time drift (RTD) of 80 nm-thick highly boron doped polysilicon nanofilms (PSNFs) with different deposition temperatures were studied here. The tunneling piezoresistive model was established to explain the relationship between the measured gauge factors (GFs) and deposition temperature. It was seen that the piezoresistance coefficient (PRC) of composite grain boundaries is higher than that of grains and the magnitude of GF is dependent on the resistivity of grain boundary (GB) barriers and the weight of the resistivity of composite GBs in the film resistivity. In the investigations on PRL and RTD, the interstitial-vacancy (IV) model was established to model GBs as the accumulation of IV pairs. And the recrystallization of metastable IV pairs caused by material deformation or current excitation is considered as the prime reason for piezoresistive nonlinearity (PRNL) and RTD. Finally, the optimal deposition temperature for the improvement of film performance and reliability is about 620 °C and the high temperature annealing is not very effective in improving the piezoresistive performance of PSNFs deposited at lower temperatures.
A Neural Network-Based Optimization Algorithm for the Static Weapon-Target Assignment Problem (1989)

A neural network-based algorithm was developed for the static weapon-target assignment problem in ballistic missile defense. An optimal assignment policy is one which allocates targets to weapon platforms such that the total expected leakage value of targets surviving the defense is minimized. This involves the minimization of a nonlinear objective function subject to inequality constraints specifying the maximum number of interceptors available to each platform and the maximum number of interceptors allowed to be fired at each target as imposed by the battle management/command control and communications system. The algorithm consists of solving a system of ordinary differential equations whose trajectories are the assignment variables of the problem. Simulations of the algorithm on PC and VAX computers were carried out using a simple numerical scheme. In all the battle instances tested, the algorithm has proven to be stable and to converge to solutions very close to global optima. The time to achieve convergence was consistently less than the time constant of the network's processing elements (neurons). This suggests that fast solutions can be realized if the algorithm is implemented in hardware circuits. Three series of battle scenarios are analyzed and discussed in detail. The main advantage of this algorithm is that it can be adapted to either a special-purpose hardware circuit or a general-purpose concurrent machine to yield fast and accurate solutions to difficult decision problems. INFORMS Journal on Computing, ISSN 1091-9856, was published as ORSA Journal on Computing from 1989 to 1995 under ISSN 0899-1499.
Algorithms on optimal driving strategies for train control problem (2002)

A train travels from a station to the next along tracks with gradient and speed limits. The journey must be completed within a given time, and it is desirable to minimise energy consumption. In this paper, we use the fuel consumption model and present different algorithms with some numerical examples.
A Trinuclear Pd−Diimine Catalyst for “Core-First” Synthesis of Three-Arm Star Polyethylenes via Ethylene “Living” Polymerization (2009)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTA Trinuclear Pd−Diimine Catalyst for "Core-First" Synthesis of Three-Arm Star Polyethylenes via Ethylene "Living" PolymerizationKejian Zhang, Zhibin Ye*, and Ramesh SubramanianView Author Information School of Engineering, Laurentian University, Sudbury, Ontario P3E 2C6, Canada* Corresponding author: e-mail [email protected]; Fax 1(705) 675-4862.Cite this: Macromolecules 2009, 42, 7, 2313–2316Publication Date (Web):March 10, 2009Publication History Received21 January 2009Revised26 February 2009Published online10 March 2009Published inissue 14 April 2009https://pubs.acs.org/doi/10.1021/ma900139fhttps://doi.org/10.1021/ma900139frapid-communicationACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views1573Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Ethylene polymerization,Hydrocarbons,Living polymerization,Star polymers Get e-Alerts
GPU-based Parallel Computing for Nonlinear Finite Element Deformation Analysis (2014)

Computer-based surgical simulation and non-rigid medical image registration in image-guided interventions are examples of applications that would benefit from real-time deformation simulation of soft tissues. The physics of deformation for biological soft-tissue is best described by nonlinear continuum mechanics-based models which then can be discretized by the Finite Element Method (FEM) for a numerical solution. Computational complexity of nonlinear FEM-based models has limited their use in real-time applications. The data-parallel nature and intense arithmetic operations in nonlinear FEM models are suitable for massive parallelization of the computations, in order to meet the response time requirements in such applications. This thesis is concerned with computational aspects of complex nonlinear deformation analysis problems with an emphasis on the speed of response using a parallel computing philosophy. It proposes a fast, accurate and scalable Graphic Processing Unit (GPU)-based implementation of the total Lagrangian FEM using implicit time integration for dynamic nonlinear deformation analysis. This is a general formulation valid for large deformations and strains and can account for material nonlinearities. A penalty method is used to satisfy the physical boundary constraints due to contact between deformable objects. The proposed set of optimized GPU kernels for computing the FEM matrices achieves more than 100 GFLOPS on a GTX 470 GPU device. The use of a novel vector assembly kernel and memory optimization strategies result in a performance gain of up to 25 GFLOPS in the PCG computations.
<title>Evaluation of high-thermal-conductivity graphite fibers for thermal management in electronics applications</title> (1999)

High thermal conductivity carbon fibers are orthotropic, having significantly different properties in the longitudinal (650 - 1100 W/mK) and radial directions (15 - 50 W/mK). These fibers can function like thermal 'pipes' to directionally transport heat from one location to another. The potential of such high thermal conductivity materials to facilitate enhanced thermal management in miniaturized electronics systems used in space applications is considered. Visualization of heat flow using time-resolved infrared imaging and analysis of the capabilities of different fabricated structures for directing heat flow will be described.
Electrochemical Demineralization of Water with Porous Electrodes of Large Surface Area (1960)

Research began as an investigation of electrically induced ionic adsorption on porous "inert" electrodes. Electrode pairs based on carbon have been developed which will demineralize saline water at low voltage, and can be regenerated upon reversal of polarity. Various carbon electrodes have been conveniently classified into cation- and anion-responsive types. As received carbons are normally cation-responsive, but anion-responsive types have been made by chemical treatment. Laboratory demineralization cells based on this principle have been constructed and operated. Owing primarily to the low cost of basic construction materials, the process shows great promise for the economical conversion of saline waters.