gebhart/patrepeval huggingface dataset:
Function of Tissue-type Plasminogen Activator Releaser on Vascular Endothelial Cells and Thrombolysis In Vivo (2002)

The effect of monosodium[2-(6-hydroxynaphthalen-2-yl)-6-methylpyrimidin-4-yloxy]acetate dihydrate (JTV-926) on fibrinolysis was investigated in vitro and in vivo. JTV-926 released tissue-type plasminogen activator (t-PA) from human vascular endothelial cells in a dose-dependent manner. The thrombolytic effect of JTV-926 was studied using three animal thrombosis models; a photo-irradiation-induced mouse carotid artery thrombosis model, a photo-irradiation-induced rat femoral artery thrombosis model and a thrombin-induced rat venous thrombosis model. In the mouse thrombosis model, t-PA deficient mice (t-PA-/- mice) and their wild-type (t-PA+/+) were used. JTV-926 was injected as a bolus 30 min after the interruption of blood flow by an occlusion thrombi. Blood flow was continuously monitored for 180 min after intravenous administration of JTV-926 (1 mg/kg). Although the recanalization rate of the occluded artery was 37.5% in t-PA +/+ mice with the vehicle control, it increased to 75% in t-PA+/+ mice after JTV-926 administration. However, when JTV-926 was administrated in t-PA-/- mice, vascular recanalization was not observed in any arteries. In the photo-irradiation-induced rat femoral artery thrombosis model, intra-duodenal administration of JTV-926 induced thrombolysis. Moreover, in the thrombin-induced rat venous thrombosis model, the dose-dependent thrombolysis was also observed by oral administration of JTV-926. It was suggested that JTV-926 revealed a sufficient thrombolytic effect through the absorption from the intestine. Thus, a newly synthesized compound, JTV-926 induced t-PA release from vascular endothelial cells and effective thrombolysis in vivo.
Activation of the Sap-1a Transcription Factor by the c-Jun N-terminal Kinase (JNK) Mitogen-activated Protein Kinase (1997)

Ternary complex factors (TCFs) bind to the serum response element in the c-fos promoter and mediate its activation by many extracellular stimuli. Some of these stimuli activate the ERK subclass of mitogen-activated protein kinases (MAPKs) that target the TCF Sap-1a. We show that Sap-1a is also phosphorylated by the stress-activated JNK subclass of MAPKs leading to stimulation of both c-fos serum response element and E74-site-dependent transcription in RK13 cells. Several JNK-1 phosphorylation sites were mapped within Sap-1a, and mutation of these sites affected the transactivation mediated by Sap-1a and JNK-1. The impact of these phosphorylation sites varied at different promoters and was dependent on whether Sap-1a was stimulated by ERK-1 or JNK-1. Additionally, a comparison of Sap-1a with another TCF, Elk-1, revealed that these proteins behaved differently to stimulation by ERK-1 and JNK-1. Furthermore, activation of Sap-1a by JNK-1 was inhibited by the p38(MAPK) in RK13 cells, possibly by competition for a common upstream activator. Altogether, our data suggest that Sap-1a plays an important role in the nuclear response elicited by cellular stress.
Dynamic speech discrimination using an articulatory model (1979)

The author proposes a dynamic processing method corresponding to the human one. It uses an articulator model representing the tongue and the lip movements to extract speech features from speech waveforms. He uses a linear enhancement of the articulatory movements in order to estimate their target articulatory positions, when the target positions are used for vowel discrimination, the correct rate is improved fairly well For example, ten males' symmetrical vowel V1, V2V1 are analyzed and V2 discrimination correct rate is improved from 85% to 100%. Next, hearing tests show that such dynamic process corresponds well to the human auditory system.
Structure–Activity Studies on Suramin Analogues as Inhibitors of NAD<sup>+</sup>‐Dependent Histone Deacetylases (Sirtuins) (2007)

Suramin is a symmetric polyanionic naphthylurea originally used for the treatment of trypanosomiasis and onchocerciasis. Suramin and diverse analogues exhibit a broad range of biological actions in vitro and in vivo, including, among others, antiproliferative and antiviral activity. Suramin derivatives usually target purinergic binding sites. Class III histone deacetylases (sirtuins) are amidohydrolases that require nicotinamide adenine dinucleotide (NAD(+)) as a cofactor for their catalytic mechanism(.) Deacetylation of the target proteins leads to a change in conformation and alters the activity of the proteins in question. Suramin was reported to inhibit human sirtuin 1 (SIRT1). We tested a diverse set of suramin analogues to elucidate the inhibition of the NAD(+)-dependent histone deacetylases SIRT1 and SIRT2 and discovered selective inhibitors of human sirtuins with potency in the two-digit nanomolar range. In addition, the structural requirements for the binding of suramin derivatives to sirtuins were investigated by molecular docking. The recently published X-ray crystal structure of human SIRT5 in complex with suramin and the human SIRT2 structure were used to analyze the interaction mode of the novel suramin derivatives.
Effects of Water Sources and Fertilizers on Peanut Plants in the Greenhouse (1971)

Experiments were conducted using different sources of water (tap. lake. distilled, acidified tap. and acidified distilled water) and different fertilizer treat· menu to seek the best method of growing peanut planu under greenhouse con­ ditions. Distilled water proved to be best; acidification of tap water was beneficial. Use of acidifying soluble fertilizers (21-7-7 and 20-20-20) in combination with distilled water. sand, and plastic pots gave good results. We have experienced considerable diffi­ culty from time to time in growing healthy peanut plants in our greenhouse. Early growth usually appears to be normal, but gradual deterioration in the appearance of the plants takes place shortly after bloom­ ing. The symptoms most often observed are a general yellowing of the plants, mottling of the leaves, browning of leaf margins, and lack of vigor. Inadequate fertility might have been considered to be the cause of the problem, had we not experi­ enced similar difficulties when several fer­ tility treatments and soil media were used. Some preliminary evidence indicated that the trouble might be caused or accentuated by the source of the water we used. To gain further evidence as to whether or not different water sources might have an influence on peanut growth and produc­ tion, tbe following three experiments were designed.
Saturated double-resonance emission spectroscopy of lead for sensitive atomic analysis (1981)

Double-resonance laser emission at 283.3 and 600.2 nm was used to excite gas-phase atomic lead present in an electrothermal atomizer. Buffer-gas-induced collisional energy transfer occurs to states as much as 6000 cm−1 below the highest optically pumped level. Single photons emitted from these states, whose wavelengths are as short as 202.2 nm, were detected. This study illustrates the utility and versatility of the saturated double-resonance technique for ultrasensitive and specific atomic detection (detection limits in the 10−15-g range) as well as its potential in atomic-spectroscopy and excited-state-dynamics studies.
Rap1 Can Bypass the FAK-Src-Paxillin Cascade to Induce Cell Spreading and Focal Adhesion Formation (2012)

We developed new image analysis tools to analyse quantitatively the extracellular-matrix-dependent cell spreading process imaged by live-cell epifluorescence microscopy. Using these tools, we investigated cell spreading induced by activation of the small GTPase, Rap1. After replating and initial adhesion, unstimulated cells exhibited extensive protrusion and retraction as their spread area increased, and displayed an angular shape that was remodelled over time. In contrast, activation of endogenous Rap1, via 007-mediated stimulation of Epac1, induced protrusion along the entire cell periphery, resulting in a rounder spread surface, an accelerated spreading rate and an increased spread area compared to control cells. Whereas basal, anisotropic, spreading was completely dependent on Src activity, Rap1-induced spreading was refractory to Src inhibition. Under Src inhibited conditions, the characteristic Src-induced tyrosine phosphorylations of FAK and paxillin did not occur, but Rap1 could induce the formation of actomyosin-connected adhesions, which contained vinculin at levels comparable to that found in unperturbed focal adhesions. From these results, we conclude that Rap1 can induce cell adhesion and stimulate an accelerated rate of cell spreading through mechanisms that bypass the canonical FAK-Src-Paxillin signalling cascade.
Gene Substitution/Knockout to Delineate the Role of α<sub>2</sub>‐Adrenoceptor Subtypes in Mediating Central Effects of Catecholamines and Imidazolines (1999)

Adrenergic receptors form the interface between the sympathetic nervous system and the cardiovascular system as well as many endocrine and parenchymal tissues. For the three alpha 2-adrenergic receptors (alpha 2A, alpha 2B, and alpha 2C), genetic mouse models have been developed that can be used to elucidate the physiologic function of each receptor subtype in vivo. Different strategies for homologous recombination in embryonic stem cells were applied to generate lines of mice with gene knockouts of the individual alpha 2-receptor subtypes (alpha 2A-KO, alpha 2B-KO, and alpha 2C-KO) or with a substitution of a mutant receptor at the wild-type locus (alpha 2-D79N). In these transgenic mice, the cardiovascular effects of alpha 2-agonists and imidazoline receptor agonists were tested. Stimulation of alpha 2B receptors in vascular smooth muscle produces hypertension and counteracts the clinically beneficial hypotensive effect of stimulating alpha 2A receptors in the central nervous system.
A low-cost wearable radiation sensor based on dose response viability of yeast cells (2016)

We present the first low-cost wearable radiation sensor that combines a MEMS structure with a microorganism (yeast) and utilizes the dose-response effect of ionizing radiation on yeast cells as a biologically relevant surrogate to measure radiation. Yeast cells are robust microorganisms which are semi-resistant to ionizing radiation. When exposed to radiation, yeast suffers DNA damage, mutations, and/or death, resulting in their decreased viability and ability to ferment a sugar solution. As a result, they provide a physical response (i.e., gas generation) to radiation that is biologically significant (DNA damage). Our dosimeter uses yeast housed in a low cost wearable MEMS structure as a biologically sensitive radiation indicator (canary in the coal mine). The dose response viability of yeast cells and the resulting gas generation in presence of sucrose solution is used to deflect a PDMS membrane and activate an LED indicator. The sensor allows radiation detection with sensitivity of -0.195 mm/decade-rad (1-1000 rad).
A 6-bit 600-MS/s 5.3-mW asynchronous ADC in 0.13-μm CMOS (2006)

An asynchronous analog-to-digital converter (ADC) based on successive approximation is used to provide a high-speed (600-MS/s) and medium-resolution (6-bit) conversion. A high input bandwidth ( 4 GHz) was achieved which allows its use in RF subsampling applications. By using asynchronous pro- cessing techniques, it avoids clocks at higher than the sample rate and speeds up a nonbinary successive approximation algorithm utilizing a series nonbinary capacitive ladder with digital radix calibration. The sample rate of 600 MS/s was achieved by time-in- terleaving two single ADCs, which were fabricated in a 0.13- m standard digital CMOS process. The ADC achieves a peak SNDR of 34 dB, while only consuming an active area of 0.12 mm and having power consumption of 5.3 mW. Index Terms—Analog-to-digital conversion, analog integrated circuits, asynchronous logic circuits, calibration, capacitive ladder, comparators, high-speed integrated circuits, impulse radio, non- binary successive approximation, ultra-wideband (UWB).
Multi-keyword Similarity Search over Encrypted Cloud Data (2014)

Searchable encryption allows one to upload encrypted documents on a remote honest-but-curious server and query that data at the server itself without requiring the documents to be decrypted prior to searching. In this work, we propose a novel secure and efficient multi-keyword similarity searchable encryption (MKSim) that returns the matching data items in a ranked ordered manner. Unlike all previous schemes, our search complexity is sublinear to the total number of documents that contain the queried set of keywords. Our analysis demonstrates that proposed scheme is proved to be secure against adaptive chosen-keyword attacks. We show that our approach is highly efficient and ready to be deployed in the real-world cloud storage systems.
High-speed laser chemical vapor deposition of copper: A search for optimum conditions (1989)

The photothermal laser-induced chemical vapor deposition of copper is studied as a function of the writing speed, the light intensity, and the diameter of the focal spot on the substrate, at three different pressures of the copperbishexafluoroacetylacetonate precursor. The height, the width, and the electrical conductivity of the deposited metal stripes are measured. The metalorganic vapor pressure is the key variable for attaining high writing speeds. Copper stripes have been obtained at 1 mm s−1 .
Periodontal disease and the oral microbiota in new‐onset rheumatoid arthritis (2012)

Patients with new-onset RA exhibited a high prevalence of PD at disease onset, despite their young age and paucity of smoking history. The subgingival microbiota profile in patients with new-onset RA was similar to that in patients with chronic RA and healthy subjects whose PD was of comparable severity. Although colonization with P gingivalis correlated with the severity of PD, overall exposure to P gingivalis was similar among the groups. The role of A geminatus and Prevotella/Leptotrichia species in this process merits further study.
Enumerators for protograph-based ensembles of nonbinary LDPC codes (2011)

This paper considers the ensemble enumerators of protograph-based nonbinary (PB NB) LDPC codes. Equipped with combinatorial definitions extended to the nonbinary domain, ensemble enumerators of codeword weight, trapping set size and stopping set size are calculated. The exact enumerators are presented in the finite-length regime, and the corresponding growth rates are calculated in the asymptotic regime. Our results can provide useful analytical tools for a range of communication and storage applications employing nonbinary LDPC codes.
A carboxy-terminus truncated analog of angiotensin II, [Sar1]angiotensin II-(1-7)-amide, provides an entry to a new class of angiotensin II antagonists (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA carboxy-terminus truncated analog of angiotensin II, [Sar1]angiotensin II-(1-7)-amide, provides an entry to a new class of angiotensin II antagonistsP. R. Bovy, A. J. Trapani, E. G. McMahon, and M. PalomoCite this: J. Med. Chem. 1989, 32, 3, 520–522Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/jm00123a002https://doi.org/10.1021/jm00123a002research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
General method for the modification of different BAC types and the rapid generation of BAC transgenic mice (2003)

Most genome projects have relied on the sequencing of bacterial artificial chromosomes (BACs), which encompass 100-300 kb of genomic DNA. As a consequence, several thousand BAC clones are now mapped to the human and mouse genome. It is therefore possible to identify in silico a BAC clone that carries a particular gene and obtain it commercially. Given the large size of BACs, most if not all regulatory sequences of a gene are present and can be used to direct faithful and tissue-specific expression of heterologous genes in vitro in cell cultures and in vivo in BAC-transgenic mice. We describe here an optimized and comprehensive protocol to select, modify, and purify BACs in order to generate BAC-transgenic mice. Importantly, this protocol includes a method to generate, within 2 days, complex plasmid cassettes required to modify BACs, and to efficiently modify different types of BACs selected from the two major BAC libraries available. Altogether, using a combination of genomic database analysis, overlap PCR cloning, and BAC recombination in bacteria, our approach allows for the rapid and reliable generation of "pseudo knockin" mice. genesis 38:39-50, 2004.
Deep convolutional neural network and 3D deformable approach for tissue segmentation in musculoskeletal magnetic resonance imaging (2017)

The study demonstrates that the combined CNN and 3D deformable modeling approach is useful for performing rapid and accurate cartilage and bone segmentation within the knee joint. The CNN has promising potential applications in musculoskeletal imaging. Magn Reson Med 79:2379-2391, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
A simple derivation of the autocorrelation of a random pulse train (1970)

A simple derivation is given for the autocorrelation of the random process y(t) = Σ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</inf> h <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</inf> (t-t <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</inf> ) where the random function h <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</inf> (t) is idependent of {t <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</inf> } and of h <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</inf> (t), n ≠ k, and {t <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</inf> } is a random point process (not necessarily stationary). The results are applied to a model of an electrical power system.
Optical properties of Al, Fe, Ti, Ta, W, and Mo at submillimeter wavelengths (1988)

Measurements of the optical constants of metals at submillimeter wavelengths are sparse. We have used a nonresonant cavity to measure, at room temperature, the angle averaged absorptance spectra P(omega) of aluminum, molybdenum, tantalum, titanium, tungsten, and iron in the 30-300-cm(-1) wavenumber region. The real part of the normalized surface impedance spectrum, z(omega) = r(omega) + ix(omega), was determined from P(omega). Measurements were also made on iron from 400 to 4000 cm(-1) using standard reflectance techniques. The r(omega) spectrum was combined with previous measurements by others at higher frequencies and Kramers-Kronig analyses of the resultant combined r(omega) spectra provided epsilon(omega) = epsilon(1)(omega) + iepsilon(2)(omega) and N(omega) = n(omega) + ik(omega).
Automated Generation and Integration of AUTOSAR ECU Configurations (2019)

Automotive Open System Architecture (AUTOSAR) is a system-level standard that is formed by the worldwide partnership of the automotive manufacturers and suppliers who are working together to develop a standardized Electrical and Electronic(E/E) framework and architecture for automobiles. The AUTOSAR methodology has two main activities: system configuration and the Electronic Control Unit (ECU) configuration. The system configuration is the mapping of the software components to the ECUs based on the system requirements. The ECU configuration process is an important part of the ECU software integration and generation. ECU specific information is extracted from the system configuration description and all the necessary information for the implementation such as tasks, scheduling, assignments of the runnables to tasks and configuration of the Basic Software (BSW) modules, are performed. This activity allows the ECU to modify the configuration parameters based on the vendor-specific requirements. Due to the high complexity and redundancy of this process, it has to be supported by different tool-related editors that can automatically generate source files like *.c and *.h for the configuration. In this thesis, we propose a method to automate the ECU configuration process for AUTOSAR. We use configuration templates written in xtend programming language along with a BSW generator tool developed at APAG Elektronik. This tool can extract the configuration parameters and automatically generate the required ECU module configuration. The Watchdog module will be used as an example to generate and integrate the ECU configuration. This enables the seamless generation of the software configurations from the system level requirements to the software implementation and therefore ensures consistency, correctness, cost efficiency and reduces the work done by the developer to generate the configuration.
Atomic-scale imaging of asymmetric Lomer dislocation cores at the Ge/Si(001) heterointerface (2004)

Lomer edge dislocations formed at Ge/Si(001) hetero-interfaces have been imaged with a 1.25-MeV atomic-resolution electron microscope. The dislocation cores were primarily asymmetrical, and they were located close to the mean position of the interface, which was not structurally abrupt due to Ge–Si interdiffusion at the growth temperature of 550 °C. Structural models of the asymmetric dislocation cores could be derived directly from the experimental micrographs and image simulations were then used to validate the image interpretation.
Chimaeric Rabbits from Embryonic Cell Transplantation (1974)

Embryonic single cells were successfully transplanted into preimplantation intact rabbit blastocysts. Phenotypic expression of the recipient blastocyst-donor cells genetic differences in the eye, skin, and coat color evidenced successful participation of transplanted cells in recipients organogenesis. An additional measure was the significant disproportionate sex ratio favoring the male in experimental neonates. It is, therefore, clearly established that the rabbit is a suitable model for micrurgical cell transplantation and further studies of cell interactions.