gebhart/patrepeval huggingface dataset:
System-level power-performance trade-offs in bus matrix communication architecture synthesis (2006)

System-on-chip communication architectures have a significant impact on the performance and power consumption of modern multi-processor system-on-chips (MPSoCs). However, customization of such architectures for an application requires the exploration of a large design space. Thus designers need tools to rapidly explore and evaluate relevant communication architecture configurations exhibiting diverse power and performance characteristics. In this paper we present an automated framework for fast system-level, application-specific, power-performance trade-offs in bus matrix communication architecture synthesis. Our paper makes two specific contributions. First, we develop energy macro-models for system-level exploration of bus matrix communication architectures. Second, we incorporate these macro-models into a bus matrix synthesis flow that enables designers to efficiently explore the power-performance design space of different bus matrix configurations. Experimental results show that our energy macro-models incur less than 5% average absolute error compared to gate-level models. Furthermore, our bus matrix synthesis framework generates a tradeoff space with designs that exhibits an approximately 20% variation in power and 40% variation in performance on an industrial networking MPSoC application, demonstrating the utility of our approach.
An AP2‐type transcription factor, WRINKLED1, of <i>Arabidopsis thaliana</i> binds to the AW‐box sequence conserved among proximal upstream regions of genes involved in fatty acid synthesis (2009)

Although an APETALA2 (AP2)-type transcription factor, WRINKLED1 (WRI1), has been shown to be required for accumulation of triacylglycerols (TAGs) in Arabidopsis seeds, its direct target genes have not been established. Overexpression of WRI1 up-regulated a set of genes involved in fatty acid (FA) synthesis in plastids, including genes for a subunit of pyruvate kinase (Pl-PKbeta1), acetyl-CoA carboxylase (BCCP2), acyl carrier protein (ACP1), and ketoacyl-acyl carrier protein synthase (KAS1), while expression of these genes is reduced in mutants with reduced WRI1 expression. Transient expression of LUC reporter genes with the proximal sequences upstream from the ATG codon of Pl-PKbeta1, BCCP2, and KAS1 in protoplasts was activated by co-expression of WRI1, and recombinant WRI1 bound to these upstream sequences in vitro. The seven WRI1 binding sites shared a sequence [CnTnG](n)(7)[CG], where n is any nucleotide designated as the AW-box, and mutations in AW-boxes near the transcription start site and in the 5'-untranslated region of Pl-PKbeta1 abolished activation by WRI1 in protoplasts and expression during seed maturation. Although expression of genes for the synthesis of TAGs and packaging into oil bodies in the endoplasmic reticulum in developing seeds required WRI1, their expression was not up-regulated by WRI1 overexpression. Thus, WRI1 promotes the flow of carbon to oil during seed maturation by directly activating genes involved in FA synthesis and controlling genes for assembly and storage of TAG.
<i>S</i> tem Cell <i>T</i> herapies as an <i>E</i> merging <i>P</i> aradigm in <i>S</i> troke (STEPS) (2008)

Investigators developing cellular therapy for stroke face many challenges. Preclinical models used for cellular therapy studies should be relevant to human stroke and predictive of benefit despite differences in stroke size, cerebrovascular anatomy, immune status, and neurological responses. Translating preclinical testing to human trials is compounded by consideration of delivery method and translation of dosing with cell survival. Many issues must be approached in designing clinical trials of cellular therapy for stroke, including appropriate outcome measures, controlling for confounding factors such as rehabilitation therapy, and possible surrogate outcomes using imaging such as MRI and newer imaging techniques. It is also important to establish standardized clinical protocols and clinical database registries in advance of early proof-of-concept studies. Investigators must adopt a standardized nomenclature and characterization schema for cell products to accurately define potency and determine clinical outcome from early proof-of-concept studies. The Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS) meeting was organized to bring together clinical and basic researchers with industry and regulatory representatives to assess the critical issues in the field and to create a framework to guide future investigations.
Time-Variant Characterization and Compensation of Wideband Circuits (2007)

Many wideband circuits use interleaving to extend bandwidth leaving them with a cyclically time-variant output. This paper describes a technique for characterization of these types of circuits based on least-squares estimation of the time-varying response of circuits. Applying the methodology to a 90-nm, 12-GS/s 8-bit digitally-equalized DAC, shows significant timing varying behavior. Furthermore, using the data obtained from characterization to construct linear time-variant compensation improves the DAC signal-to-distortion ratio by at least 6 dB.
Sole means navigation in US Navy aircraft (1988)

The current edition of the US Federal Radionavigation Plan, issued in 1984, presents a consolidated federal plane on the management of those radionavigation systems which are used by both the civilian and military sectors. It states the US Dept. of Defense (DoD) goal to phase out the use of TACAN, VOR/DME, OMEGA, LORAN C, and TRANSIT in military platforms and for Global Positioning System (GPS) to become the standard radionavigation system for DoD. This would eliminate all the current sole-means air navigation systems (TACAN and VOR/DME) aboard military aircraft. Instrument Flight Rule (IFR) operations within controlled airspace requires an operating sole-means air navigation system to be aboard the aircraft. The authors investigate the requirements for GPS certification as a sole means air navigation system in the US National Airspace System (NAS); discuss the implication for GPS user equipment (UE) hardware and software; describe the actual UE implementation; and discuss approaches for UE integration with flight instruments on US Navy aircraft.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A monoclonal antibody to beta 1 integrin (CD29) stimulates VLA-dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components. (1992)

The leukocyte beta 1 integrin receptor very late activation antigen-4 (VLA-4) (alpha 4 beta 1, CD49d/CD29) binds to vascular cell adhesion molecule-1 (VCAM-1) expressed on cytokine-activated endothelium. A mAb designated 8A2 was identified that stimulated the binding of U937 cells to CHO cells transfected with VCAM-1 cDNA but not endothelial-leukocyte adhesion molecule or CD4 cDNA. mAb 8A2 also rapidly stimulated the adherence of peripheral blood lymphocytes (PBLs) to VCAM-1-transfected CHO cells or recombinant human tumor necrosis factor-treated human umbilical vein endothelial cells. mAb 8A2-stimulated binding of PBL was inhibited by mAbs to VLA-4 or VCAM-1. Surface expression of VLA-4 was not altered by mAb 8A2 treatment and monovalent Fab fragments of mAb 8A2 were active. Immunoprecipitation studies reveal that mAb 8A2 recognizes beta 1-subunit (CD29) of integrin receptors. In contrast to mAbs directed to VLA-4 alpha-subunit (alpha 4, CD49d), mAb 8A2 did not induce homotypic aggregation of PBL. Additionally, mAb 8A2 stimulated adherence of PBL and hematopoietic cell lines to purified matrix components laminin and fibronectin. This binding was blocked by mAbs to the VLA alpha-subunits alpha 6 (CD49f), or alpha 5 (CD49e) and alpha 4 (CD49d), respectively. We conclude that mAb 8A2 modulates the affinity of VLA-4 and other leukocyte beta 1 integrins, and should prove useful in studying the regulation of beta 1 integrin function.
VIVE LA DIFFÉRENCE: Males vs Females in Flies vs Worms (1996)

For 600 million years, the two best-understood metazoan species, the nematode Caenorhabditis elegans and fruit fly Drosophila melanogaster, have developed independent strategies for solving a biological problem faced by essentially all metazoans: how to generate two sexes in the proper proportions. The genetic program for sexual dimorphism has been a major focus of research in these two organisms almost from the moment they were chosen for study, and it may now be the best-understood general aspect of their development. In this review, we compare and contrast the strategies used for sex determination (including dosage compensation) between "the fly" and "the worm" and the way this understanding has come about. Although no overlap has been found among the molecules used by flies and worms to achieve sex determination, striking similarities have been found in the genetic strategies used by these two species to differentiate their sexes.
Selective Enrichment of Cysteine-Containing Peptides Using SPDP-Functionalized Superparamagnetic Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub> Nanoparticles: Application to Comprehensive Proteomic Profiling (2008)

Superparamagnetic Fe(3)O(4)@SiO(2) core-shell nanoparticles (ca. 30 nm diameter), which are surface-modified with a thiol-specific functional group, exhibit superb capturing efficiency toward cysteinyl peptides without contamination from nonspecifically interacting peptides, as clearly evidenced through LC/MS/MS analysis.
5. Chondrules as Condensation Products (1977)

The formation of meteoritic chondrules via condensation from the primordial solar nebula is discussed. Chondrule formation in regions where the gas/dust ratio was enhanced, and where transient high energy events heated the gas and temporarily vaporized the dust, is advocated. The observed diversity of chondrule types can be understood as resulting from local variations in the initial gas/dust proportions and other parameters.
Temporal Patterns in Colorectal Cancer Incidence, Survival, and Mortality From 1950 Through 1990 (1994)

The gender differences in colorectal cancer mortality rate trends observed from 1950 through 1984 are due to differences in incidence rate trends between males and females. Declining colorectal mortality rates in the late 1980s for males and females appear to reflect improved early detection. The peaking and subsequent decline of stage-specific incidence rates at later years for successively lower stage indicate sequential stage shifts as cancers are detected increasingly earlier over time. The increased use of sigmoidoscopy and fecal occult blood tests (triggering colonoscopy) appears to have played an important role in reducing colorectal cancer mortality. Improvements in birth cohort trends in risk for colorectal cancer for each sex suggest that lifestyle changes may have also contributed to the steady reductions in colorectal cancer mortality.
Jules Verne: a new polishing technique related to FJP (2004)

A variation on the fluid jet polishing (FJP) technique, arbitrarily named Jules Verne (JV), will be described in this article. Jules Verne is a glass processing technique that removes material due to the fact that the tool and the surface are in close contact, and a slurry moves in between the tool and the surface. This approach has both advantages and disadvantages with respect to the original FJP modus: it enables a feed-controlled machining process, but deeper lying areas are harder to reach. A simulation model will be presented that predicts the flow of the slurry in the Jules Verne setup, which is followed by the computation of the trajectories of the particles in the flow. Furthermore, experimental data will be reported demonstrating the feasibility of the JV idea. A model will also be presented simulating the interaction between the surface and the impinging abrasives at a microscopic level, enabling the prediction of the final surface roughness.
A Small-molecule Screen Yields Idiotype-specific Blockers of Neuromyelitis Optica Immunoglobulin G Binding to Aquaporin-4 (2012)

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system caused by binding of anti-aquaporin-4 (AQP4) autoantibodies (NMO-IgG) to AQP4 on astrocytes. A screen was developed to identify inhibitors of NMO-IgG-dependent, complement-dependent cytotoxicity. Screening of 50,000 synthetic small molecules was done using CHO cells expressing human AQP4 and a human NMO recombinant monoclonal antibody (rAb-53). The screen yielded pyrano[2,3-c]pyrazoles that blocked rAb-53 binding to AQP4 and prevented cytotoxicity in cell culture and spinal cord slice models of NMO. Structure-activity analysis of 82 analogs yielded a blocker with IC(50) ∼ 6 μm. Analysis of the blocker mechanism indicated idiotype specificity, as (i) pyrano[2,3-c]pyrazoles did not prevent AQP4 binding or cytotoxicity of other NMO-IgGs, and (ii) surface plasmon resonance showed specific rAb-53 binding. Antibody structure modeling and docking suggested a putative binding site near the complementarity-determining regions. Small molecules with idiotype-specific antibody targeting may be useful as research tools and therapeutics.
Serum Fructosamine as a Screening Test for Diabetes in the Elderly: A Pilot Study (1993)

This study demonstrated that a single measurement of either first or second generation fructosamine showed promise as a screening test for diabetes, but not impaired glucose tolerance, in older people.
Étude d'interrupteurs à explosion de feuilles en cuivre pour des courants de l'ordre du méga-ampère (1974)

Un modèle théorique d'explosion de feuille utilisant essentiellement l'hypothèse de l'onde de vaporisation permet d'expliquer les principales caractéristiques des phénomènes obtenus expérimentalement. Le domaine de validité de ce modèle recouvre les modes d'explosion les mieux adaptés à la réalisation d'interrupteurs à ouverture très rapide (autour d'1 μs de temps d'ouverture) pour des courants de l'ordre du méga-ampère. La théorie et les expériences montrent que le temps d'ouverture de ce type d'interrupteurs peut être environ le dixième de leur temps de fermeture et non le quart seulement comme il est couramment admis. Ce résultat ouvre de nouvelles possibilités aux procédés de stockage et de transfert d'énergie magnétique.
Acceleration of metal plates (1989)

High-explosive charges have been used to accelerate stainless steel plates to velocities of 6-7 km/s. A two-stage system has been used in which the first stage is a plane-wave detonating system that accelerates the plate down a short barrel. The second stage consists of a hollow cylindrical charge through which the moving plate passes. After an adjustable delay this charge is detonated on the outer circumference of the entry side of the charge. Flash radiographs and witness plates show no breakup in the first stage but bowing and frequent breakup in the second stage. 6 figs.
Methodology for Determine the Moment of Disconnection of Patients of the Mechanical Ventilation using Neural Network (2013)

The process of weaning from mechanical ventilation is one of the challenges in intensive care units. In this paper 66 patients under extubation process (T-tube test) were studied: 33 patients with successful trials and 33 patients who failed to maintain spontaneous breathing and were reconnected. Each patient was characterized using 7 time series from respiratory signals, and for each serie was extracted 4 statistics data. Two types of Neural Networks were applied for discriminate between patients from the two groups: radial basis function and multilayer perceptron, getting better results with the second type of network.
CARISMA: Context-Aware Reflective mIddleware System for Mobile Applications (2003)

Mobile devices, such as mobile phones and personal digital assistants, have gained wide-spread popularity. These devices will increasingly be networked, thus enabling the construction of distributed applications that have to adapt to changes in context, such as variations in network bandwidth, battery power, connectivity, reachability of services and hosts, etc. In this paper, we describe CARISMA, a mobile computing middleware which exploits the principle of reflection to enhance the construction of adaptive and context-aware mobile applications. The middleware provides software engineers with primitives to describe how context changes should be handled using policies. These policies may conflict. We classify the different types of conflicts that may arise in mobile computing and argue that conflicts cannot be resolved statically at the time applications are designed, but, rather, need to be resolved at execution time. We demonstrate a method by which policy conflicts can be handled; this method uses a microeconomic approach that relies on a particular type of sealed-bid auction. We describe how this method is implemented in the CARISMA middleware architecture and sketch a distributed context-aware application for mobile devices to illustrate how the method works in practice. We show, by way of a systematic performance evaluation, that conflict resolution does not imply undue overheads, before comparing our research to related work and concluding the paper.
Composite Materials in Aircraft Structures (1989)

SINCE the public debut of its progenitor, the Hawker P 1127 at the 1962 Farnborough Air Show its descendants, the Kestrel and the Harrier have continued to astonish and delight the crowds, both hardened professionals and the general public at Air Shows throughout the free world.
PHYTOENE AS A PROTECTIVE AGENT AGAINST SUNBURN (>280nm) RADIATION IN GUINEA PIGS (1975)

Abstract— Phytoene, the colorless triene precursor of β‐carotene (17 mg/g body weight) or a placebo was given to guinea pigs by daily intraperitoneal injection for 14 days, after which the animals were exposed to radiation (> 280 nm). It was found that the animals receiving phytoene developed significantly less erythema to the radiation than did the animals receiving placebo.
AutoGrow: A Novel Algorithm for Protein Inhibitor Design (2009)

Due in part to the increasing availability of crystallographic protein structures as well as rapid improvements in computing power, the past few decades have seen an explosion in the field of computer-based rational drug design. Several algorithms have been developed to identify or generate potential ligands in silico by optimizing the ligand-receptor hydrogen bond, electrostatic, and hydrophobic interactions. We here present AutoGrow, a novel computer-aided drug design algorithm that combines the strengths of both fragment-based growing and docking algorithms. To validate AutoGrow, we recreate three crystallographically resolved ligands from their constituent fragments.
Architecture and VLSI implementation of digital symbol timing recovery for DTV receivers (1999)

Completely digital symbol timing recovery architectures have advantages over the conventional mixed analog and digital approach, such as ease of system integration (especially for VLSI implementations) and flexible sampling rates. This paper is split into two main parts. The first part describes a digital symbol timing recovery architecture designed for digital television (DTV) receivers and also presents the associated design tradeoffs. The second part discusses an important aspect of the VLSI implementation of the architecture, which is the design and verification of the system clocking scheme.
The Excessive Complement Activation in Fulminant Meningococcal Septicemia Is Predominantly Caused by Alternative Pathway Activation (1996)

The relative contribution of the classical and alternative pathways in complement activation was quantified in 20 patients with systemic meningococcal disease. The activation products C4bc, C4bd, and Bb, indicating classical and alternative pathway activation, were measured with neoepitope-specific EIAs. Ten patients with persistent septic shock had significantly higher levels of Bb (P<.001), but not of C4bc (P=.43), than did 10 patients without septic shock. The Bb levels were significantly correlated with C3 activation products (C3bc; r= .72, P=.002), terminal SC5b-9 complement complex (TCC; r=.89, P<.001), and plasma lipopolysaccharides (LPS; r=.69, P= .01). There was no such association for C4bc versus C3bc, TCC, or LPS. Serially collected samples demonstrated activation of both pathways in patients with or without shock. Intervention strategies to stop the massive complement activation in fulminant meningococcal septicemia should include therapeutic principles that inhibit the alternative pathway.
The Effect of Infectious Bursal Disease Virus Infection on Local and Systemic Antibody Responses following Infection of 3-Week-Old Broiler Chickens (1988)

Broiler chickens infected at 3 weeks of age with infectious bursal disease virus (IBDV) were given Brucella abortus (BA) or sheep red blood cell (SRBC) antigens before, during, and after the acute phase of the infection. Gland of Harder (GH) extracts and serum samples were used to assay local and systemic antibody titer to each antigen 7 days after antigen was administered. Antibody titers to both BA and SRBC antigens were lower (P less than 0.05) in GH extracts and serum of IBDV-infected broilers than uninfected controls. The responses to BA, a thymus-independent antigen, took longer to become depressed than the responses to SRBC, a thymus-dependent antigen. The depression of antibody titers following IBDV inoculation suggests compromise of both local and systemic immune function, a finding of importance to the broiler industry.
Fibromodulin Binds Collagen Type I via Glu-353 and Lys-355 in Leucine-rich Repeat 11 (2007)

Fibromodulin belongs to the small leucine-rich repeat proteoglycan family, interacts with collagen type I, and controls collagen fibrillogenesis and assembly. Here, we show that a major fibromodulin-binding site for collagen type I is located in leucine-rich repeat 11 in the C terminus of the leucine-rich repeat domain. We identified Glu-353 and Lys-355 in repeat 11 as essential for binding, and the synthetic peptide RLDGNEIKR, including Glu-353 and Lys-355, inhibits the binding of fibromodulin to collagen in vitro. Fibromodulin and lumican compete for the same binding region on collagen, and fibromodulin can inhibit the binding of lumican to collagen type I. However, the peptide RLDGNEIKR does not inhibit the binding of lumican to collagen, suggesting separate but closely situated fibromodulin- and lumican-binding sites in collagen. The collagen-binding Glu-353 and Lys-355 residues in fibromodulin are exposed on the exterior of the beta-sheet-loop structure of the leucine-rich repeat, which resembles the location of interacting residues in other leucine-rich repeat proteins, e.g. decorin.