gebhart/patrepeval huggingface dataset:
Activity of the Fibroblast Growth Factor Receptor Inhibitors Dovitinib (TKI258) and NVP-BGJ398 in Human Endometrial Cancer Cells (2013)

The recent identification of activating fibroblast growth factor receptor 2 (FGFR2) mutations in endometrial cancer has generated an opportunity for a novel target-based therapy. Here, we explore the therapeutic potential of 2 FGFR inhibitors, the multikinase inhibitor dovitinib (TKI258) and the more selective FGFR inhibitor NVP-BGJ398 for the treatment of endometrial cancer. We examined the effects of both inhibitors on tumor cell growth, FGFR2 signaling, cell cycle, and apoptosis using a panel of 20 molecularly characterized human endometrial cancer cell lines. Anchorage-independent growth was studied using soft agar assays. In vivo studies were conducted using endometrial cancer xenograft models. Cell lines with activating FGFR2 mutations (S252W, N550K) were more sensitive to dovitinib or NVP-BGJ398 when compared with their FGFR2 wild-type counterparts (P = 0.073 and P = 0.021, respectively). Both agents inhibited FGFR2 signaling, induced cell-cycle arrest, and significantly increased apoptosis in FGFR2-mutant lines. In vitro, dovitinib and NVP-BGJ398 were both potent at inhibiting cell growth of FGFR2-mutant endometrial cancer cells, but the activity of dovitinib was less restricted to FGFR2-mutant lines when compared with NVP-BGJ398. In vivo, dovitinib and NVP-BGJ398 significantly inhibited the growth of FGFR2-mutated endometrial cancer xenograft models. In addition, dovitinib showed significant antitumor activity in FGFR2 wild-type endometrial cancer xenograft models including complete tumor regressions in a long-term in vivo study. Dovitinib and NVP-BGJ398 warrant further clinical evaluation in patients with FGFR2-mutated endometrial cancer. Dovitinib may have antitumor activity in endometrial cancer beyond FGFR2-mutated cases and may permit greater flexibility in patient selection.
Multiplex Protein Signature for the Detection of Bladder Cancer in Voided Urine Samples (2013)

The study provides further evidence that the reported panel of diagnostic biomarkers can reliably achieve the noninvasive detection of bladder cancer with higher sensitivity than currently available urine based assays.
Fustian in Naples (1965)

Journal Article Fustian in Naples Get access A. O. V. P. A. O. V. P. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s3-VII, Issue 171, 8 April 1865, Page 280, https://doi.org/10.1093/nq/s3-VII.171.280-a Published: 08 April 1965
Biological Effects of ω-3 Fatty Acids in Diabetes Mellitus (1991)

Fish oils exert important biological effects on several pathways predisposing to atherosclerosis. Epidemiological studies provided the initial evidence that omega-3 fatty acids may be the principal factor in fish oils responsible for these effects and have led to several short-term clinical trials in which fish-oil concentrates have been administered to various populations at risk for coronary heart disease, including patients with diabetes mellitus. omega-3 Fatty acids reduce serum lipids and lipoproteins, impair platelet aggregation, increase cell membrane fluidity, and lower blood pressure in humans. In this review, we highlight these and other potentially antiatherogenic properties of marine lipids in diabetic subjects.
[Studies of enzymatic synthesis of biodiesel]. (2003)

Biodiesel, an alternative diesel fuel, fatty acid alkyl ester, is made from renewable biological sources such as vegetable oils and animal fats. Two processes for biodiesel synthesis, enzymatic lipase catalytic esterification from fatty acid and transesterification from oils and fats, was investigated. The effects of various lipases, enzyme amount and purity, solvent, water absorbent, inhibition of short chains alcohol, specificity of substrate, molar ratio of substrate on esterification were studied in detail. The esterification degree with the optimal parameter and process can reach up to 92%. The purity of biodiesel obtained by separation and purification is up to 98%, and the half-life of the immobilized lipase for the esterification process can be up to 360hr, Moreover, the preliminary studies of the transesterification including the amount of methanol and mode of adding methanol into reaction system were made. The transesterification degree with adding methanol stepwise can reach 83%.
Policy Tools for Electronics Recycling Characteristics of a specific certificate market design (2006)

Several countries across the globe have implemented or are about to implement specific electronics recycling regulations based on the principle of extended producer responsibility (EPR). Both existing and proposed solutions are implemented with various degrees of centralization; one solution involves a steering regulatory authority, another connects the EPR with strong competitive market structures. As different WEEE recycling approaches evolve, the best way to achieve a cost- and eco-efficient system organization is still contentious. Theoretical system characteristics intended by policy-makers and their realization in practice often don't coincide. Practical implementations can give rise to absurd organizational outcomes. Some incentive structures are counterproductive, and actual environmental purposes of recycling legislation are often poorly reflected. This paper presents a specific certificate market tool that potentially has intriguing properties in terms of system performance, control, organization and cost. The approach introduces competition on several levels in the value chain and sets incentives for the eco-efficient treatment of WEEE. In addition, it enables decentralized decision-making which is one of the key levers for a cost-efficient system organization in a competitive market setting
Automated Murmurs: The Social Mobile Tourist Application (2009)

The popularity of mobile devices and their increased computing power has given rise to surge in mobile computing technologies. Users are increasingly turning to mobile devices for information relating to their activities and location while on the move. Independent of this, the world has seen a huge uptake in the social web, which has fueled the production of applications where users are the sole providers of valuable information. In this work we present a mobile platform which leverages the popularity of mobile and social computing to produce a location sensitive messaging system which delivers user generated content to the public in the context of their physical location.
Effects of Logging, Drought, and Fire on Structure and Composition of Tropical Forests in Sabah, Malaysia (1989)

This paper describes the impact of fire in logged-over and primary tropical forests in Sabah in terms of mortality and resultant canopy loss among saplings and trees. Prospects for recovery of forest structure and species composition are analyzed with reference to successional patterns commonly observed after natural or man-made gap forming processes
Agricultural ammonia sensor using diode lasers and photoacoustic spectroscopy (2005)

A trace-gas sensor based on fibre-amplifier enhanced photoacoustic spectroscopy has been developed for measuring ambient ammonia in agricultural settings. The sensor was built in an enclosure for continuous, unattended operation in dusty and humid conditions. Lab testing yielded benchmark results of sub-ppm sensitivity with a measurement time of 1 min and a linearity of 99.99%. Field testing was performed in environmental chambers at UC Davis where the excreta from three Holstein cows were allowed to accumulate, providing a source of ambient ammonia. The photoacoustic sensor measured the ambient ammonia in the room as it increased from below the detection threshold, up to 8 ppm, operating over a three-day period. Intercomparison measurements with the Federal reference method (EPA 40 CFR, using sulfuric acid filled impingers to trap ammonia and subsequent analysis using ion chromatography) yielded good to excellent correlation.
Assessment of lectin activity in a toxic and a non-toxic variety ofJatropha curcas using latex agglutination and haemagglutination methods and inactivation of lectin by heat treatments (1998)

Lectin activity in a toxic (Cape Verde) and non-toxic (Mexico) variety of Jatropha curcas seed meal was investigated using latex agglutination and haemagglutination assays. Lectin activity expressed as reciprocal of the minimum quantity (in mg) of Jatropha meal per ml of the assay mixture which produced agglutination with the latex beads was 2·88 ± 0·57 and 1·71 ± 0·00 (mean ± SD, n = 3) for the toxic and the non-toxic varieties, respectively, which did not differ significantly (P > 0·05), while with the haemagglutination assay these values were 102 and 51, respectively, and differed significantly (P < 0·05). The lectins were inactivated by heating and moist heat was more effective than dry heat. The results suggest that lectins may not be responsible for short term toxicity caused by consumption of raw Jatropha meal. © 1998 SCI.
Synthesis and Derivatization of Iridium(I) and Iridium(III) Pentamethyl[60]fullerene Complexes (2004)

An iridium(I) pentamethyl[60]fullerene complex, Ir(η5-C60Me5)(CO)2 (1), was prepared by the reaction of K(C60Me5) with [IrCl(CO)2]2 in an acetonitrile/THF solution. Oxidation of the iridium atom of 1 by I2 successfully proceeded to afford an iridium(III) complex, Ir(η5-C60Me5)I2(CO) (2), in 80% yield. Ligand exchange reactions of 1 took place to give phosphine complexes, Ir(η5-C60Me5)(CO)(PEt3) (3b) and Ir(η5-C60Me5)(CO)(PPh3) (3c), in 60% and 35% yields, respectively. Similarly, the Ir(I) phosphine complex Ir(η5-C60Me5)(CO)(PMe3) (3a) was also obtained by the reaction of 2 with PMe3 in 92% yield via reduction of the complex, while treatment of 2 with XylNC (Xyl = 2,6-dimethylphenyl isocyanide) gave another Ir(III) complex, Ir(η5-C60Me5)I2(XylNC) (4), in 93% yield. MeMgBr and PhCCMgBr reacted with 2 to give alkyl and alkynyl complexes, Ir(η5-C60Me5)Me2(CO) (5) and Ir(η5-C60Me5)(CCPh)2(CO) (6), in 60% and 81% yields, respectively. The molecular structures of 1, 2, and 3a were determined by X-ray crystallographic analysis. Cyclic voltammetric investigation of 1 and 2 revealed the electrochemical properties of the Ir(I) and Ir(III) complexes. Complex 1 showed three reversible one-electron-reduction waves in the cathodic scan, and one reversible two-electron-oxidation wave in the anodic scan, while the complex 2 exhibited two-electron reduction of the metal center and one-electron reduction of the fullerene part. The isolated diiodide complex 2 will be a useful starting material for the synthesis of various metal fullerene complexes.
Replacing Phosphorus with Sulfur for the Efficient Hydrogenation of Esters (2013)

Catalyst tune-up: A readily available, air-stable amino-sulfide catalyst, [RuCl(2)(PPh(3)){HN(C(2)H(4)SEt)(2)}], has been developed. This complex displays outstanding efficiency for the hydrogenation of a broad range of substrates with C=X bonds (esters, ketones, imines), as well as for the acceptorless dehydrogenative coupling of ethanol to ethyl acetate.
High-pass bird-cage coil for nuclear-magnetic resonance (1988)

Cylindrical bird-cage coils generate uniform magnetic fields transverse to the cylinder axis for use in the large sample nuclear-magnetic resonance (NMR) experiments. We describe the design and construction of an eight-rung high-pass bird-cage coil to operate at 80 MHz in a cylindrical bore of a superconducting magnet. The coil is 12.7 cm in diameter by 30.5 cm long and has a 7-cm-diam region in the center where the field intensity is within 10% of the average.
Post-Transcriptional Regulation of Cadherin-11 Expression by GSK-3 and β-Catenin in Prostate and Breast Cancer Cells (2009)

Cadherin-11 mRNA and protein levels are regulated by the activity of GSK3beta and a significant degree of this regulation is exerted by the GSK3 target, beta-catenin, at the level of the cadherin-11 3'UTR.
Engineering and characterization of a single chain surrogate light chain variable domain (2008)

The surrogate light chain (SLC) is a key regulator of B cell development in the bone marrow, resulting in mature B cells that produce antibodies that are capable of interacting with antigens. The SLC comprises two noncovalently interacting proteins: VpreB and 14.1. We engineered a construct to represent the complete immunoglobulin-like domain of the SLC variable domain in a single protein chain that could be bacterially expressed. In this construct, the incomplete immunoglobulin domain of VpreB (residues 1-102) was linked to the J-segment of 14.1 (residues 40-53), which provided one beta-strand to complete the V-like domain (VpreBJ). Because VpreBJ has the interface to VH chains, but lacks the unique region of 14.1, which is important for SLC signaling, we predict that a properly folded VpreBJ would have the potential to act as a dominant negative mutant of the surrogate light chain. X-ray crystallography of VpreBJ at 2.0 A resolution showed that the engineering was successful. With its two beta-pleated sheets, packed face-to-face, the single chain VpreBJ resembles a mature light chain immunoglobulin V-domain (VL). The surface that would normally interact with the VH chain interacts with a crystallographically related VpreBJ molecule. The presence of dimeric species in solution was verified by analytical ultracentrifugation. VpreBJ is easily overexpressed in bacteria, while retaining the native conformation of an immunoglobulin domain, and thus may serve as an important reagent for future studies in B-cell development.
Permian K-rich volcanic rocks of Devon: petrogenesis, tectonic setting and geological significance (1987)

ABSTRACT Potassium (K)-rich volcanic rocks occur within Permian sedimentary rocks in SW England and are approximately contemporaneous with the emplacement of the Cornubian granite batholith. The volcanic rocks have chemical characteristics of subduction-related magmas and may have been derived by small amounts of partial melting of heterogeneous large-ion lithophile (LIL) enriched mantle with the assemblage olivine–pyroxene–garnet–phlogopite–titanate. The LIL enrichment may have occurred during shallow or oblique subduction of oceanic lithosphere below SW England during the Devonian and Carboniferous. Such LIL-enriched mantle may have contributed some components to the Cornubian granite batholith.
Recombinase Polymerase Amplification Assay for Rapid Detection of Francisella tularensis (2012)

Several real-time PCR approaches to develop field detection for Francisella tularensis, the infectious agent causing tularemia, have been explored. We report the development of a novel qualitative real-time isothermal recombinase polymerase amplification (RPA) assay for use on a small ESEQuant Tube Scanner device. The analytical sensitivity and specificity were tested using a plasmid standard and DNA extracts from infected rabbit tissues. The assay showed a performance comparable to real-time PCR but reduced the assay time to 10 min. The rapid RPA method has great application potential for field use or point-of-care diagnostics.
Amino acid sequence of ferredoxin from Clostridium acidiurici (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmino acid sequence of ferredoxin from Clostridium acidiuriciS. C. Rall, Robert E. Bolinger, and R. David ColeCite this: Biochemistry 1969, 8, 6, 2486–2496Publication Date (Print):June 1, 1969Publication History Published online1 May 2002Published inissue 1 June 1969https://pubs.acs.org/doi/10.1021/bi00834a035https://doi.org/10.1021/bi00834a035research-articleACS PublicationsRequest reuse permissionsArticle Views27Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ultra-high <i>Q</i> even eigenmode resonance in terahertz metamaterials (2015)

We report the simultaneous excitation of the odd and the even eigenmode resonances in a periodic array of square split-ring resonators, with four resonators per unit cell. When the electric field is parallel to their gaps, only the two well-studied odd eigenmodes are excited. As the resonators are rotated relative to one another, we observe the emergence and excitation of an extremely sharp even eigenmode. In uncoupled split-ring resonators, this even eigenmode is typically radiative in nature with a broad resonance linewidth and low Q-factor. However, in our coupled system, for specific range of rotation angles, our simulations revealed a remarkably high quality factor (Q ∼ 100) for this eigenmode, which has sub-radiant characteristics. This type of quad-supercell metamaterial offers the advantage of enabling access to all the three distinct resonance features of the split-ring resonator, which consists of two odd eigenmodes in addition to the high-Q even eigenmode, which could be exploited for high performance multiband filters and absorbers. The high Q even eigenmode could find applications in designing label free bio-sensors and for studying the enhanced light matter interaction effects.
Synthesis of a Potential Heparanase Inhibitor (1994)

Abstract Aza-analog of the basic disaccharide unit in heparan sulfate was designed as a potential inhibitor against heparanase produced by solid tumor cells, and synthesized via a coupling reaction of a phenyl 2-azido-1-thio-d-glucopyranoside derivative with a partially protected 1-deoxynojirymycin derived from d-glucose, followed by manipulation such as imino acid formation, O-sulfation.
Altered photosynthetic performance of a natural Arabidopsis accession is associated with atrazine resistance (2005)

Natural variation for photosynthetic traits was studied by determining chlorophyll fluorescence parameters in a collection of Arabidopsis accessions. This screen revealed only one single accession (Ely), exhibiting photosynthetic characteristics markedly different from all others, while a few lines showed small but significant variation. Detailed genetic and physiological analyses showed reduced fitness for Ely compared with the standard laboratory strain Ler for various growth parameters. At low temperature (15 degrees C), Ely had a higher electron transport rate than Ler, indicating increased photosystem II efficiency under this condition, while at high temperature (30 degrees C) the opposite was observed. Ely had a high sensitivity to UV-B radiation compared with Ler and was atrazine resistant. This atrazine-resistance and related chlorophyll fluorescence traits were maternally inherited, pointing towards chloroplast-located gene(s). Definite proof that Ely is atrazine-resistant was obtained by sequencing the psbA gene, encoding the D1 protein of photosystem II, revealing a point mutation causing the same amino acid change as found in other atrazine-resistant species. Additional nuclear encoded genetic variation was also present, as was concluded from the small but significant differences in phenotype between Ely and its reciprocal crosses with Ler. It was concluded that the photosynthetic yield is highly conserved and that only severe selection pressure results in marked variations in photosynthetic performance.
Control Strategy for Power Conditioning System of Large Capacity Cascaded Battery Energy Storage System (2012)

Large capacity cascaded battery energy storage system(BESS) is one of the effective means to solve the problem of grid-connection of renewable energy resource such as large-scale wind farm.In allusion to the control strategy for power conditioning system(PCS) of BESS,the proportional resonant(PR) regulator is used to implement the control with zero-steady-state error for instantaneous power in α-β coordinate system;the balancing control of the state of charge(SOC) among clusters,namely the bridge arms of each phase in cascaded BESS,is implemented by means of injecting zero-sequence votlage and the SOC balance of units within the cluster is realized through adding corresponding AC voltage.Simulation results show that faster dynamic response and smaller steady-state error of PCS adopting the control strategy can be attained in instantaneous power control,meanwhile the balancing control of SOC can be achieved effectively,thus,the correctness and feasibility of the control strategy are verified.
Synthesis of Monodisperse Spiro-Bridged Ladder-Type Oligo-<i>p</i>-phenylenes (2007)

Monodisperse spiro-bridged ladder-type oligo-p-phenylenes, which have very rigid backbones, exhibited intensive emissions with very small Stocks shifts, displayed very good color stability upon thermo-oxidation, and were synthesized by Suzuki cross-coupling, oxidation, and BF3.ether-catalyzed cyclization reactions.
Random‐access distributed fiber sensing (2012)

Abstract Optical sensing offers an attractive solution to the societal concern for prevention of natural and human‐generated threats and for efficient use of natural resources. The unprecedented properties of optical fibers make them ideal for implementing a ‘nervous system’ in structural health monitoring: they are small, low‐cost and electrically and chemically inert. In particular, the nonlinear interaction of stimulated Brillouin scattering allows for the distributed measurement of strain and temperature with tens of km range. In this work, a novel, radar‐inspired technique for random‐access Brillouin scattering‐based sensors is shown, making a significant step towards a real optical sensing nerve. The method selectively addresses each fiber segment as a distinct sensing element in a synaptic neuronal system. The measurement principle relies on phase‐coding of both the Brillouin pump and signal waves by a high‐rate, pseudo‐random bit sequence. Temperature measurements with 1 cm resolution are reported. The measurement range is scalable to several km.
Imaging crystal stress in diamond using ensembles of nitrogen-vacancy centers (2019)

We present a micrometer-scale-resolution stress imaging method with millimeter field-of-view for diamonds containing a thin surface layer of nitrogen-vacancy (NV) centers. In this method, we reconstruct stress tensor elements over a two-dimensional field of view from NV optically detected magnetic resonance (ODMR) spectra. We use this technique to study how stress inhomogeneity affects NV magnetometry performance and show how NV ${M}_{z,\ensuremath{\kappa}}$ imaging is a useful and direct way to assess these effects. This tool for mapping stress in diamond will aid optimization of NV-diamond sensing, with wide-ranging applications in the physical and life sciences.
A Modified Gardner Detector for Symbol Timing Recovery of&lt;tex&gt;$M$&lt;/tex&gt;-PSK Signals (2004)

In this letter, we propose a modified version of the Gardner detector for symbol timing recovery of M-ary phase-shift keying (M-PSK) signals. Simulation results show that the proposed modification leads to significant performance improvement when M-PSK signals are highly bandlimited and M is small. Specifically, the reduction in the level of self-noise due to the modification amounts to 10.7 dB for quaternary phase-shift keying signals with the rolloff factor of 0.25 and the normalized noise-equivalent loop bandwidth of 0.005. In terms of computational complexity involved, the proposed method has an advantage over the known self-noise reduction methods for M-PSK signals with small M.