gebhart/patrepeval huggingface dataset:
Adjustable Fractional-Delay FIR Filters Using the Farrow Structure and Multirate Techniques (2006)

The Farrow structure can be used for efficient realization of adjustable fractional-delay finite-length impulse response (FIR) filters, but, nevertheless, its implementation complexity grows rapidly as the bandwidth approaches the full bandwidth. To reduce the complexity, a multirate approach can be used. In this approach, the input signal is first interpolated by a factor of two via the use of a fixed half-band linear-phase FIR filter. Then, the actual fractional-delay filtering takes place. Finally, the so generated signal is downsampled to retain the original input/output sampling rate. In this way, the bandwidth of the fractional-delay filter used is halved compared to the overall bandwidth. Because the complexity of half-band linear-phase FIR filter interpolators is low, the overall complexity can be reduced. In this paper, we present more implementation details, design trade-offs, and comparisons when the filters are implemented using multiple constant multiplication techniques, which realize a number of constant multiplications with a minimum number of adders and subtracters
Pulse-density modulation for RF applications: The radio-frequency power amplifier (RF PA) as a power converter (2008)

Switching processes such as pulse-width and pulse-density modulation have been used for many years in power electronics applications. Due to rapid scaling of semiconductor technology, similar approaches may be successfully applied to blocks in the radio architecture. This work outlines the implementation of a class-D power amplifier for RF applications in low-GHz frequency bands. We describe the motivation for using pulse-density modulation (PDM) to achieve linear amplitude modulation of a nominally nonlinear switching power amplifier. The amplifier achieves linearity suitable for wideband wireless standards, with peak efficiency of 43.5% at 1.95 GHz and up to 20 dBm output power. The system generates amplitude-modulated waveforms with up to 20 MHz envelope bandwidth, demonstrating the validity of this approach for modern communication standards.
Hutchinson v. Proxmire: The Vanishing Immunity under the Speech or Debate Clause, 14 J. Marshall L. Rev. 263 (1980) (1980)

Knowledge will forever govern ignorance.And people who mean to be their own governors, must arm themselves with the power knowledge gives.A popular government without popular information or the means of acquiring it, is but a prologue to a farce or a tragedy, or perhaps both."
Hybrid diagnostic strategy for an expert system controlled automatic test system (EXATS) (2003)

A prototype automated diagnosis system for a real-world unit under test (UUT) is presented. The system features a time-optimized test sequence with feedback of correctly diagnosed failures and a reduction of effort for test program development and maintenance. The diagnostic strategy used involves associative and model-based diagnosis. The experimental knowledge is organized as a hierarchical rulebase structure according to diagnoses. To model physical knowledge, a technique using logic programming extended by functions is introduced.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Recent Advances from the National Cancer Institute Alliance for Nanotechnology in Cancer (2010)

Nanotechnology will have great impact on how cancer is diagnosed and treated in the future. New technologies to detect and image cancerous changes and materials that enable new methods of cancer treatment will radically alter patient outcomes. The National Cancer Institute (NCI) Alliance for Nanotechnology in Cancer sponsors research in cancer prevention, diagnosis, and therapy and promotes translation of basic science discoveries into clinical practice. The Fourth Annual NCI Alliance Principal Investigator Meeting was held in Manhattan Beach, California October 20-22, 2009. Presented here are highlights from the research presentations at the meeting, in the areas of in vitro diagnostics, targeted delivery of anticancer and contrast enhancement agents, and nanotherapeutics and therapeutic monitoring.
Potential antifertility agents. 2. Tetrazole derivatives of nonsteroidal estrogens (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotential antifertility agents. 2. Tetrazole derivatives of nonsteroidal estrogensR. R. Crenshaw, G. M. Luke, and G. BialyCite this: J. Med. Chem. 1972, 15, 11, 1179–1180Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://pubs.acs.org/doi/10.1021/jm00281a023https://doi.org/10.1021/jm00281a023research-articleACS PublicationsRequest reuse permissionsArticle Views83Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Overview of ITU-T NGN QoS Control (2007)

This article presents an overview of standards activities defining the QoS control architecture. Several standards bodies define the QoS control architectures based on their scope of work. This article first reviews the QoS control architectures defined in the standards bodies such as Cable Lab, DSL Forum, MSF, ETSI, and ITU-T. ITU-T NGN architecture provides the generic framework to cover the results of each standards body. Other architectures focus on solving specific problems. We explain in more detail the ITU-T QoS control architecture defined in resource and admission control functions (RACF) and discuss future standards developments.
A modular high-throughput architecture for logarithmic search block-matching motion estimation (1998)

A high-throughput modular architecture for a logarithmic search block-matching algorithm is presented. The design efforts are focused on exploiting the search area data dependencies using special data input ordering constraints. The input bandwidth problem has been solved by a random access on-chip memory, and a simple address generation procedure has been described. Furthermore, this architecture can handle a large search range with unequal horizontal and vertical spans using a technique called pipeline interleaving. Compared to the existing architectures for the three-step search BMA, this architecture delivers a high throughput rate with fewer input lines, and is linearly scalable.
The use of implant-supported ceramometal titanium prostheses following sinus lift and augmentation procedures: a clinical report. (1998)

This clinical report presents rationale and clinical procedures involved in the use of ceramometal implant-supported titanium-cast prostheses for the rehabilitation of patients with atrophic maxillae requiring iliac crest grafting procedures. Favorable clinical results have been obtained, although clinical observation periods have been limited. The present observations suggest that osseointegrated ceramometal titanium prostheses could form a valuable part of restorative therapy following augmentation procedures. Furthermore, these titanium prostheses may be a meaningful contribution to implant prosthodontics, facilitating restorations of optimum biocompatibility.
A generic geometric calibration method for tomographic imaging systems with flat‐panel detectors—A detailed implementation guide (2010)

Purpose To present a generic geometric calibration method for tomographic imaging systems with flat‐panel detectors in a very detailed manner, in the aim to provide a useful tool to the public domain. Methods The method is based on a projection matrix which represents a mapping from 3D object coordinate system to 2D projection image plane. The projection matrix can be determined experimentally through the imaging of a phantom of known marker geometry. Accurate implementation was accomplished through direct computation algorithms, including a novel ellipse fitting using singular value decomposition and data normalization. Benefits of the method include: (1) It is capable of being applied to systems of different scan trajectories, source‐detector alignments, and detector orientations; (2) projection matrices can be utilized in image reconstructions or in the extraction of explicit geometrical parameters; and (3) the method imposes minimal limits on the design of calibration phantom. C++ programs that calculate projection matrices and extract geometric parameters from them are also provided. For validation, the calibration method was applied to the computer simulation of a cone‐beam CT system, as well as to three tomosynthesis prototypes of different source‐detector movement patterns: Source and detector rotating synchronizedly; source rotating and detector wobbling; and source rotating and detector staying stationary. Results Projection matrices were computed on a view by view basis. Geometric parameters extracted from projection matrices were consistent with actual settings. Images were reconstructed by directly using projection matrices, and were compared to virtual Shepp–Logan image for CT simulation and to central projection images of CIRS breast phantoms for tomosynthesis prototypes. They showed no obvious distortion or blurring, indicating the high quality of geometric calibration results. When the computed central ray offsets were perturbed with Gaussian noises of 1 pixel standard deviation, the reconstructed image showed apparent distortion, which further demonstrated the accuracy of the geometric calibration method. Conclusions The method is suitable for tomographic imaging systems with flat‐panel detectors.
SIROLIMUS-ASSOCIATED PULMONARY TOXICITY (2004)

The temporal relationship between sirolimus exposure and onset of pulmonary symptoms in the absence of infectious causes and other alternative pulmonary disease and the associated clinical and radiologic improvement after its cessation suggests a causal relationship. Because the use of sirolimus in organ transplantation has become more widespread, clinicians must remain vigilant to its potential pulmonary complication.
Eribulin mesylate in patients with refractory cancers: a Phase I study (2011)

Eribulin mesylate (Halaven™, E7389) is a synthetic analog of the marine natural product halichondrin B that acts via a mechanism distinct from conventional tubulin-targeted agents. This Phase I study (clinicaltrials.gov identifier: NCT00326950) was the first to investigate eribulin mesylate in Japanese patients. The study determined the recommended dose, MTD, DLTs, safety, pharmacokinetics, and antitumor activity of eribulin administered on Days 1 and 8 of a 21-day cycle in Japanese patients with advanced solid tumors. Fifteen patients received eribulin mesylate 0.7-2.0 mg/m(2) as a 2- to 10-min intravenous injection. Neutropenia was the principal DLT. DLTs were observed in two of six patients treated at 1.4 mg/m(2), and in all three patients at 2.0 mg/m(2). The recommended dose was 1.4 mg/m(2) and the MTD was 2.0 mg/m(2). Neutropenia (67%), lymphocytopenia (20%), febrile neutropenia (33%), and fatigue (13%) were the most common grade 3 or 4 toxicities. Eribulin exhibited triphasic pharmacokinetics with a long terminal half-life, high volume of distribution, and low urinary clearance. Three patients achieved partial responses (two with NSCLC, one with head and neck cancer) at 1.4 mg/m(2) dose level. Eribulin mesylate, administered on Days 1 and 8 of a 21-day cycle, exhibits manageable tolerability at 1.4 mg/m(2). DLT was neutropenia.
Uniparental disomy as a mechanism for human genetic disease. (1988)

A female with cystic fibrosis and short stature was investigated for molecular or cytogenetic abnormalities that might explain the combined phenotype. Analysis with polymorphic DNA markers indicated that the father did not contribute alleles to the propositus for markers near the CF locus or for centromeric markers on chromosome 7. High-resolution cytogenetic analysis was normal, and the result could not be explained on the basis of nonpaternity or a submicroscopic deletion. All of the data indicate that the propositus inherited two identical copies of maternal sequences for much or all of chromosome 7. The occurrence of uniparental disomy could be explained by models postulating postfertilization error, gamete complementation, monosomic conception with subsequent chromosome gain, or trisomic conception followed by chromosome loss. Uniparental disomy in an individual with a normal chromosome analysis is a novel mechanism for the occurrence of human genetic disease.
Sequencing Batch Reactors (2009)

A sequencing batch reactor (SBR) can be either a biological SBR (BIO-SBR) or a physicochemical SBR (PC-SBR). BIO-SBR includes traditional sedimentation biological SBR, innovative flotation biological SBR (BIO-DAF-SBR), innovative membrane biological SBR (MBR-SBR), aerobic digestion SBR (AD-SBR), etc. All PC-SBR are innovative processes including at least sedimentation PC-SBR (PC-SED-SBR), flotation PC-SBR (PC-DAF-SBR), membrane PC-SBR (PC-membrance-SBR), granular activated carbon PC-SBR (PC-GAC-SBR), powdered activated carbon PC-SBR (PC-PAC-SBR), and ion exchange PC-SBR (PC-IX-SBR). Although all BIO-SBR and PC-SBR processes are introduced, special emphasis of this chapter is placed on traditional BIO-SBR which can be used for wastewater treatment aerobically (bio-oxidation and nitrification), or anoxically/anaerobically (denitrifi-cation). The advantages, disadvantages, applications, performance, theory, operation, maintenance, design of traditional biological SBR are presented in detail. Eleven design examples and case studies for both BIO-SBR and PC-SBR are reported.
A Bidirectional DC–DC Converter for an Energy Storage System With Galvanic Isolation (2007)

This paper addresses a bidirectional dc-dc converter suitable for an energy storage system with an additional function of galvanic isolation. An energy storage device such as an electric double layer capacitor is directly connected to a dc side of the dc-dc converter without any chopper circuit. Nevertheless, the dc-dc converter can continue operating when the voltage across the energy storage device drops along with its discharge. Theoretical calculation and experimental measurement reveal that power loss and peak current impose limitations on a permissible dc-voltage range. This information may be useful in design of the dc-dc converter. Experimental results verify proper charging and discharging operation obtained from a 200-V, 2.6-kJ laboratory model of the energy storage system. Moreover, the dc-dc converter can charge the capacitor bank from zero to the rated voltage without any external precharging circuit.
Requirements for De Novo Initiation of RNA Synthesis by Recombinant Flaviviral RNA-Dependent RNA Polymerases (2002)

RNA-dependent RNA polymerases (RdRps) that initiate RNA synthesis by a de novo mechanism should specifically recognize the template initiation nucleotide, T1, and the substrate initiation nucleotide, the NTPi. The RdRps from hepatitis C virus (HCV), bovine viral diarrhea virus (BVDV), and GB virus-B all can initiate RNA synthesis by a de novo mechanism. We used RNAs and GTP analogs, respectively, to examine the use of the T1 nucleotide and the initiation nucleotide (NTPi) during de novo initiation of RNA synthesis. The effects of the metal ions Mg(2+) and Mn(2+) on initiation were also analyzed. All three viral RdRps require correct base pairing between the T1 and NTPi for efficient RNA synthesis. However, each RdRp had some distinct tolerances for modifications in the T1 and NTPi. For example, the HCV RdRp preferred an NTPi lacking one or more phosphates regardless of whether Mn(2+) was present or absent, while the BVDV RdRp efficiently used GDP and GMP for initiation of RNA synthesis only in the presence of Mn(2+). These and other results indicate that although the three RdRps share a common mechanism of de novo initiation, each has distinct preferences.
Identification and characterization of an RNA specific primer for human tumor necrosis factor receptor I (TNFR‐I) (1996)

An RNA specific primer amplified TNFR-I cDNA from cellular RNA by single-tube (ST) RT-PCR without interfering with the presence of genomic DNA of cell was identified. The primer detected TNFR-I from 1 ng of cellular RNA by ST RT-PCR, and was not cross-reacted with TNFR-II despite of the homologous sequence between TNFR-I and -II. In addition, the mechanism of the RNA specificity of the primer was investigated. An intron of 0.43 kb was inserted in the 5'-925 of TNFR-I mRNA sequence. The result corresponded with the previous determination of TNFR-I gene structure. Thus, it appears that the RNA specificity of the primer might be resulted from the antisense primer hybridizing to exon-intron junction. Owing to its high sensitivity and specificity to TNFR-I RNA, the RNA specific primer may be potentially utilized for the determination of human TNFR-I gene expression by in situ RT-PCR.
Combined Modality Therapy for Small Cell Lung Cancer (1992)

Small cell carcinoma is one of the solid cancers for which chemotherapy is effective and can prolong the survival of patients. There is a general agreement that the standard regimen is PVP (cisplatin/etoposide) or alternating PVP-CAV (cyclophosphamide/doxorubicin/vincristine) therapy, replacing CAV, which had been considered standard. For the improvement of the treatment results of small cell carcinoma combined modality therapy including radiotherapy and/or surgery is essential, especially against limited disease. The effect of prophylactic cranial irradiation is obscure, because of the relapse to other sites of organs and the late complications of brain radiation. The present status of combined modality therapy for small cell carcinoma is reviewed and the future essential trials are discussed.
[The bond between crown margin and marginal periodontium]. (1978)

Illustration shows Puck offering a large axe labeled "Repeal of Beef Tariff" to Philander C. Knox who is holding a tiny sling-shot labeled "Sherman Anti-Trust Law"; standing in the background is a large bull labeled "Beef Trust". Caption: Puck (to Attorney-General Knox) You'll never hurt that animal until they give you this ax!
Long-Range Effects of Acyl Groups in the Solvolysis of Glycofuranosyl Halides. The Synthesis of 2,3-Di-O-benzyl-5-O-p-nitrobenzoyl-α-D- arabinofuranosyl Chloride and of 2-O-Benzyl- 3,5-di-O-p-nitrobenzoyl-α-D-arabinofuranosyl Chloride (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLong-Range Effects of Acyl Groups in the Solvolysis of Glycofuranosyl Halides. The Synthesis of 2,3-Di-O-benzyl-5-O-p-nitrobenzoyl-α-D- arabinofuranosyl Chloride and of 2-O-Benzyl- 3,5-di-O-p-nitrobenzoyl-α-D-arabinofuranosyl ChlorideC. P. J. Glaudemans and Hewitt G. Fletcher Jr.Cite this: J. Am. Chem. Soc. 1965, 87, 20, 4636–4641Publication Date (Print):October 1, 1965Publication History Published online1 May 2002Published inissue 1 October 1965https://pubs.acs.org/doi/10.1021/ja00948a041https://doi.org/10.1021/ja00948a041research-articleACS PublicationsRequest reuse permissionsArticle Views291Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Web Service to Generate Intelligent Previews of Web Links (2018)

Previews of web links are typically generated based on the metadata captured from the URL content. Sometimes, the preview sentences are extracted by means of content summarization. Such web link previews can be seen in different apps like the web browser, chat app, messaging or email apps etc. These previews are static in nature and do not change with respect to changing context. Therefore, they may not be particularly relevant to the receiver of the link. In this paper, we present a web service for generating intelligent previews in a chat application, which captures the local intent of the user from the chat content and uses it to display only relevant content extracted from the previewed URL. Since the user intent can change dynamically, our system generated previews are also dynamic, which change on the fly if it detects a change of topic being discussed in the current chat. We describe details of a prototype web service implementation, with three methods for preview generation based on TF-IDF and Word2Vec word embedding. We also present results of an evaluation using shared URLs from a private real-world chat group as well as a sample chat app with a few users to determine the accuracy of the preview generation system.
A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies (2018)

CAR T-cell therapies hold great promise for treating a range of malignancies but are however challenged by the complexity of their production and by the adverse events related to their activity. Here we report the development of the CubiCAR, a tri-functional CAR architecture that enables CAR T-cell detection, purification and on-demand depletion by the FDA-approved antibody Rituximab. This novel architecture has the potential to streamline the manufacturing of CAR T-cells, allow their tracking and improve their overall safety.
A neural-network-based context-aware handoff algorithm for multimedia computing (2008)

The access of multimedia computing in wireless networks is concerned with the performance of handoff because of the irretrievable property of real-time data delivery. To lessen throughput degradation incurred by unnecessary handoffs or handoff latencies leading to media disruption perceived by users, this paper presents a link quality based handoff algorithm. Neural networks are used to learn the cross-layer correlation between the link quality estimator such as packet success rate and the corresponding context metric indictors, for example, the transmitting packet length, received signal strength, and signal to noise ratio. Based on a pre-processed learning of link quality profile, neural networks make essential handoff decisions efficiently with the evaluations of link quality instead of the comparisons between relative signal strength. The experiment and simulation results show that the proposed algorithm improves the user perceived qualities in a transmission scenario of VoIP applications by minimizing both the number of lost packets and unnecessary handoffs.