gebhart/patrepeval huggingface dataset:
ARACHIDONIC ACID METABOLISM AND MODULATION OF <i>in vitro</i> ANAPHYLAXIS BY 5,8,11,14‐EICOSATETRAYNOIC ACID AND 9a,12a‐OCTADECADIYNOIC ACID (1981)

1. 5,8,11,14-Eicosatetraynoic acid (ETYA) inhibited the antigen-induced contractions of tracheal spirals obtained from actively sensitized guinea-pigs. Consistent data were obtained only when the spirals were treated with indomethacin. 2. ETYA did not affect histamine-induced contractions of indomethacin-treated tracheal spirals. 3. 9a, 12a-Octadecadiynoic acid (Ro-3-1314) a potential inhibitor of linoleic acid metabolism, stimulated the antigen-induced contraction of guinea-pig tracheal spirals and the immunological release of slow reacting substances of anaphylaxis (SRS-A) from actively sensitized guinea-pig lung fragments. 4. Both ETYA and Ro-3-1314 inhibited the immunological release of malondialdehyde from guinea-pig lung fragments. 5. The data indicate that the effects of ETYA were due to inhibition of lipoxygenase and the effects of Ro-3-1314 were due to inhibition of cyclo-oxygenase. 6. The results suggest that products of lipoxygenase contribute to the antigen-induced contraction of guinea-pig lung, particularly when cyclo-oxygenase is inhibited. Under these conditions there may be redirection of the metabolism of arachidonic acid to favour production of constrictor products of lipoxygenase such as SRS-A.
Characteristics of Ion‐Implantation Damage and Annealing Phenomena in Semiconductors (1984)

The nature of ion‐implantation damage in silicon and gallium arsenide as a function of implantation and substrate variables has been investigated using electron microscopy and Rutherford backscattering techniques. With no annealing effects, the crystalline‐to‐amorphous transition occurs at a critical energy of 12 eV/atom for silicon. By increasing the dose rate or the substrate temperature, "defect‐free" regions with no dopant redistribution are obtained. There is a dose rate or substrate temperature window in which voids are formed, producing undesirable effects. The annealing effects at high dose rates are interchangeable with substrate temperature. A high fraction of dopants in both Si and is found to be in electrically active substitutional sites after high dose rate or high temperature implants. The origin and thermal annealing of underlying dislocation bands have been examined in detail. Subsequent annealing behavior of underlying dislocation bands is critically determined by the nature of the as‐implanted states.
Stealthy video capturer (2009)

In this paper, we investigate video-based vulnerabilities in 3G Smartphones. Particularly, we design a new video-based spyware, called Stealthy Video Capturer (SVC). SVC can secretly record video information for the third party, greatly compromising Smartphone users' privacy. We implement the spyware and conduct extensive experiments on real world 3G Smartphones. Our experimental results show that the spyware can capture private video information with unremarkable power consumption, CPU and memory occupancy, hence being stealthy to Smartphone users. Moreover, SVC can naturally be resistant to almost all commercial anti-virus tools, like McAfee, Kaspersky and F-Secure mobile version. To the best of our knowledge, our work is the first one to address video-based vulnerabilities in 3G Smartphones. We expect our work will prompt serious attentions on this issue.
D-Glucose-Water Phase Diagram (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTD-Glucose-Water Phase DiagramFrank E. YoungCite this: J. Phys. Chem. 1957, 61, 5, 616–619Publication Date (Print):May 1, 1957Publication History Published online1 May 2002Published inissue 1 May 1957https://pubs.acs.org/doi/10.1021/j150551a023https://doi.org/10.1021/j150551a023research-articleACS PublicationsRequest reuse permissionsArticle Views1476Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A high bandwidth, bypass, transient-mode sigma-delta DC-DC switching boost regulator with wide LC compliance (2005)

DC-DC switching regulators are critical building blocks in electronic systems and integrating them on chip affords numerous savings in system size, cost, and design complexity. A key portion of these regulators is the frequency compensation circuit and, because of its dependence to the passive LC filter parameters in the power stage, it resists integration. This hindrance to system-on-chip (SoC) integration can be overcome by adopting a sliding-mode control scheme, which, in implementing a variation of a sigma-delta (/spl Sigma//spl Delta/) converter, gives stable operation for a wide range of LC filter values, without the need for a frequency compensation circuit. However, sliding-mode boost DC-DC converters designed to tolerate wide LC variations exhibit a slow transient response because the bandwidth of the feedback circuit is necessarily low, significantly lower than the main power path's bandwidth, which is a requirement for stability. This paper proposes a switching boost converter with a high bandwidth, bypass, /spl Sigma//spl Delta/ path that yields fast transient response (up to 50 % /spl Delta//spl Sigma/ reduction)-limited only by slew-rate conditions. The proposed converter achieves this fast response without a degradation in LC filter compliance, steady-state voltage ripple (/spl plusmn/ 0.2 %), or efficiency. In effect, the presented strategy decouples the conflicting design requirements of high relative stability and fast transient response without requiring compensation circuits and therefore offering integrated, user-friendly solutions.
Automatic software fault diagnosis by exploiting application signatures (2008)

Application problem diagnosis in complex enterprise environments is a challenging problem, and contributes significantly to the growth in IT management costs. While application problems have a large number of possible causes, failures due to runtime interactions with the system environment (e.g., configuration files, resource limitations, access permissions) are one of the most common categories. Troubleshooting these problems requires extensive experience and time, and is very difficult to automate. In this paper, wepropose a black-box approach that can automatically diagnose several classes of application faults using applications ’ runtime behaviors. These behaviors along with various system states are combined to create signatures that serve as a baseline of normal behavior. When an application fails, the faulty behavior is analyzed against the signature to identify deviations from expected behavior and likely cause. We implement a diagnostic tool based on this approach and demonstrate its effectiveness in a number of case studies with realistic problems in widely-used applications. We also conduct a number of experiments to show that the impact of the diagnostic tool on application performance (with some modifications of platform tracing facilities), as well as storage requirements for signatures, are both reasonably low.
Using value locality to reduce memory encryption overhead in embedded processors (2007)

Memory encryption has gained much attention lately as a way to offer a secure environment to fight against software and hardware attacks. Many researchers provided memory encryption schemes whereby one or more levels of the memory hierarchy were encrypted using a cryptographic algorithm such as AES. Counter mode (CM) encryption, also called one-time-pad (OTP) encryption, is proven to be quite effective for main memory encryption. However, CM encryption requires an extra sequence number (counter) to be associated with every memory location (L2 block cacheline granularity is used). The per-block counters must be updated every time a block is written back to memory otherwise known-plaintext attacks may occur. Thus, the size of those counters is a critical parameter in the system design. In this work, we propose the use of silent stores as a method of providing the CM encryption with less overhead. Silent stores, i.e. stores, to memory that write the same value as already stored in that memory location, have been observed to occur frequently. These stores create redundant memory write-backs (and counter updates), so eliminating them will lower performance overheads introduced by the encyption/decryption process. Our initial results show significant benefits across the board indicating the promising nature of the proposed idea.
Ultrasensitive detection of malignant melanoma using PET molecular imaging probes (2020)

Malignant melanoma has one of the highest mortality rates of any cancer because of its aggressive nature and high metastatic potential. Clinical staging of the disease at the time of diagnosis is very important for the prognosis and outcome of melanoma treatment. In this study, we designed and synthesized the <sup>18</sup>F-labeled pyridine-based benzamide derivatives <i>N</i>-(2-(dimethylamino)ethyl)-5-[<sup>18</sup>F]fluoropicolinamide ([<sup>18</sup>F]DMPY2) and <i>N</i>-(2-(dimethylamino)ethyl)-6-[<sup>18</sup>F]fluoronicotinamide ([<sup>18</sup>F]DMPY3) to detect primary and metastatic melanoma at an early stage and evaluated their performance in this task. [<sup>18</sup>F]DMPY2 and [<sup>18</sup>F]DMPY3 were synthesized by direct radiofluorination of the bromo precursor, and radiochemical yields were ∼15-20%. Cell uptakes of [<sup>18</sup>F]DMPY2 and [<sup>18</sup>F]DMPY3 were >103-fold and 18-fold higher, respectively, in B16F10 (mouse melanoma) cells than in negative control cells. Biodistribution studies revealed strong tumor uptake and retention of [<sup>18</sup>F]DMPY2 (24.8% injected dose per gram of tissue [ID/g] at 60 min) and [<sup>18</sup>F]DMPY3 (11.7%ID/g at 60 min) in B16F10 xenografts. MicroPET imaging of both agents demonstrated strong tumoral uptake/retention and rapid washout, resulting in excellent tumor-to-background contrast in B16F10 xenografts. In particular, [<sup>18</sup>F]DMPY2 clearly visualized almost all metastatic lesions in lung and lymph nodes, with excellent image quality. [<sup>18</sup>F]DMPY2 demonstrated a significantly higher tumor-to-liver ratio than [<sup>18</sup>F]fluorodeoxyglucose ([<sup>18</sup>F]FDG) and the previously reported benzamide tracers <i>N</i>-[2-(diethylamino)-ethyl]-5-[<sup>18</sup>F]fluoropicolinamide ([<sup>18</sup>F]P3BZA) and <i>N</i>-[2-(diethylamino)-ethyl]-4-[<sup>18</sup>F]fluorobenzamide ([<sup>18</sup>F]FBZA) in B16F10-bearing or SK-MEL-3 (human melanoma)-bearing mice. In conclusion, [<sup>18</sup>F]DMPY2 might have strong potential for the diagnosis of early stage primary and metastatic melanoma using positron emission tomography (PET).
Biconical-taper single-mode fiber coupler (1981)

Single-mode fiber couplers produced as fused biconical-taper structures are reported on. The devices exhibit low loss (0.5 dB), arbitrary branching ratio, polarization independence, and broadband operation in wavelength.
Direct electrochemistry and EPR spectroscopy of spinach ferredoxin mutants with modified electron transfer properties (1995)

Mutations of the conserved residue Glu-92 to lysine, glutamine, and alanine have been performed in the recombinant ferredoxin I of spinach leaves. The purified ferredoxin mutants were found twice as active with respect to wild-type protein in the NADPH-cytochrome c reductase reaction catalyzed by ferredoxin-NADP+ reductase in the presence of ferredoxin. Cyclic voltammetry and EPR measurements showed that the mutations cause a change in the [2Fe-2S] cluster geometry, whose redox potential becomes approximately 80 mV less negative. These data point to a role of the Glu-92 side-chain in determining the low redox potential typical of the [2Fe-2S] cluster of chloroplast and cyanobacterial ferredoxins. Also a ferredoxin/ferredoxin-NADP+ reductase chimeric protein obtained by gene fusion was overproduced in Escherichia coli and purified. Fusion of the ferredoxin with its reductase causes only minor effects to the iron-sulfur cluster, as judged by cyclic voltammetry and EPR measurements.
Spin Squeezing in a Rydberg Lattice Clock (2014)

We theoretically demonstrate a viable approach to spin squeezing in optical lattice clocks via optical dressing of one clock state to a highly excited Rydberg state, generating switchable atomic interactions. For realistic experimental parameters, these interactions are shown to generate over 10 dB of squeezing in large ensembles within a few microseconds and without degrading the subsequent clock interrogation.
Estrogen Modulation of Apolipoprotein(a) Expression (1999)

Elevated plasma levels of the lipoprotein particle Lp(a) are a major risk factor for cardiovascular disease. Lp(a) plasma levels are determined by the level of expression of its characteristic protein component, apo(a). Apo(a) expression is modulated by several hormones, of which estrogens are the best known. The chromosomal region responsible for estrogen response was identified within an apo(a) enhancer located at approximately 26 kilobases from the apo(a) promoter. Although the estrogen-responsive unit contains a potential estrogen response element, binding of estrogen receptor-alpha to DNA was not necessary. The receptor, activated by bound estradiol, interacts through its transactivation domains with a transcription factor necessary for the function of the enhancer, preventing its binding to DNA.
A Delay-Based Multicast Overlay Scheme for WDM Passive Optical Networks With 10-Gb/s Symmetric Two-Way Traffics (2010)

We propose a delay-based multicast overlay scheme to superimpose a multicast differential phase-shift keying (DPSK) modulated signal on a point-to-point downstream inverse-return-to-zero (IRZ) modulated signal in a wavelength-division-multiplexed passive optical network (WDM-PON). By adjusting the synchronization of the DPSK and the IRZ modulation on the downstream carrier, simple and flexible multicast control could be realized. We have successfully demonstrated the proposed scheme for three different traffics, namely 10-Gb/s IRZ downstream point-to-point data, 10-Gb/s DPSK downstream multicast data, and 10-Gb/s non-return-to-zero (NRZ) upstream re-modulated data, respectively. An error floor of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> is observed for the multicast data when it is disabled. The effect of timing misalignment on the downstream DPSK/IRZ orthogonal modulation and the upstream re-modulation is analyzed. We also study the case when the data rates of the multicast and downstream point-to-point data are different.
<title>Optical wireless communication using digital pulse interval modulation</title> (1999)

This paper presents a study of digital pulse interval modulation (DPIM) as a candidate modulation scheme for optical wireless communications. DPIM code characteristics are discussed and the theoretical error probability performance of DPIM is analyzed in terms of the packet error rate. Performance comparisons are made with the more established techniques of on-off keying and pulse position modulation (PPM). We show that, for a simple threshold detector based receiver, DPIM can out perform PPM in terms of bandwidth efficiency and power efficiency, by taking advantage of its inherent variable symbol duration. Practical results are given for an experimental system in the form of eye diagrams. The use of a coding scheme with a non-uniform symbol duration does have implications for system design, which are discussed in the paper.
Beyond the Radio (2015)

Cellular network performance is often viewed as primarily dominated by the radio technology. However, reality proves more complex: mobile operators deploy and configure their networks in different ways, and sometimes establish network sharing agreements with other mobile carriers. Moreover, regulators have encouraged newer operational models such as Mobile Virtual Network Operators (MVNOs) to promote competition. In this paper we draw upon data collected by the ICSI Netalyzr app for Android to characterize how operational decisions, such as network configurations, business models, and relationships between operators introduce diversity in service quality and affect user security and privacy. We delve in detail beyond the radio link and into network configuration and business relationships in six countries. We identify the widespread use of transparent middleboxes such as HTTP and DNS proxies, analyzing how they actively modify user traffic, compromise user privacy, and potentially undermine user security. In addition, we identify network sharing agreements between operators, highlighting the implications of roaming and characterizing the properties of MVNOs, including that a majority are simply rebranded versions of major operators. More broadly, our findings highlight the importance of considering higher-layer relationships when seeking to analyze mobile traffic in a sound fashion.
A Mild Method for the Esterification of Fatty Acids (1979)

Abstract In conjunction with a synthetic problem, we were in need of a method for the stoichiometric esterification of fatty acids, containing the aqueous acid labile tert-butyl dimethylsilyloxy group (OTBS), with a variety of alcohols. It has been reported2 that fatty acids form acylureas in the presence of dicyclo-hexylcarbodiimide (DCC) and methanol3 without esterification.
Overexpression of Escherichia coli thiol peroxidase in the periplasmic space (1998)

Overproduction of Escherichia coli thiol peroxidase in the periplasmic space was achieved by locating the appropriate gene on a downstream region of the strong T7 promoter. E. coli strain BL21 carrying the recombinant plasmid pSK-TPX was induced by IPTG, lysed, and analyzed by SDS-polyacrylamide gel electrophoresis. A large amount of the overexpressed thiol peroxidase was located in the periplasmic space. A homogeneous thiol peroxidase was obtained from E. coli osmotic shock fluid by simple one-step gel permeation chromatography.
Thyroid papillary carcinoma (1983)

Pathologist, Massachusetts General Hospital; Professor of Pathology, Harvard Medical School, Boston, Massachusetts. SS-SS 579
The Development of a Speed Management Strategy for Queensland (1995)

Excessive vehicle speed - speeding - has been identified as a significant factor contributing to the incidence of serious road crashes in Queensland. A number of speed related issues are currently on the national road safety agenda, such as speed cameras and lower general urban speed limits. Queensland Transport recognized the need to develop a speed management strategy to address these matters and the relevant actions contained in the Queensland Road Safety Strategy 1993-2003, in a coordinated manner. This Paper discusses some of the issues relating to speed management and the progress towards the development of a Queensland Speed Management Strategy. It also outlines the proposed guiding principles and actions to be followed in achieving the objectives of a speed management strategy.
Electrochemiluminescence from Organic Emitters (2005)

Electrically induced light emission from conjugated organic molecules in a condensed phase has constituted one of the most investigated phenomena in the recent past for a variety of reasons. The considerable development achieved in this field has been mainly based on the search of new configurations for luminescent devices such as flexible large area light-emitting diodes, and in the synthesis of improved light-emitting organic materials. In the present review a particular aspect of electrically induced light-emission phenomena from organic materials is considered, namely, organic electrochemiluminescence, which is the phenomenon of light emission from excited organic molecules generated upon occurrence of electrochemically driven redox reactions. Such processes can produce luminescence in the visible range if the resulting oxidized/reduced forms of the conjugated organic molecules form excited species capable of emitting photons within the energy range 1.5−3.5 eV. Electrochemiluminescence from organic emitters in a condensed phase has led to the creation of devices such as light-emitting electrochemical cells, whose realization was decisive in the development of effective light-emitting devices. In the present review the description of the phenomena at the basis of organic electrochemiluminescence is given together with the description of materials and devices configurations for light-emitting electrochemical cells.
Is seropositive rheumatoid arthritis becoming less severe? (1989)

We have followed a community-based cohort of recent-onset arthritis for eight years. In addition to Waaler-Rose and latex agglutination tests we used class-specific enzyme immunoassay for the determination of rheumatoid factors (RFs). Eighty-seven patients had erosions by the end of the follow-up period. The seropositive cases in each RF assay were divided into three groups of equal size according to the mean strength of RF reactivity for three or four available follow-up specimens. The radiological index values in the high-titer groups were no higher than the values for the seropositive cases on average. Thus, no severity gradient according to RF titer could be demonstrated.
Substituent and Solvent Effects of TMS Triflate Mediated C1′ Epimerization of β-Thymidine to α-Thymidine (2002)

This paper deals with kinetic studies of TMSOTf-mediated C1′ epimerization of β-thymidine to α-thymidine. The effect of neighboring group participation by various 5′-hydroxy protecting groups, such as toluoyl, Et2CHC(O), Et2NC(O), and Et2NC(S), on the β→α conversion is described in detail. The time dependence of the ratio of the α and β anomers in the C1′ epimerization was estimated by 1H NMR. The α/β equilibrium constants K and the rate constants kα and kβ were calculated on the basis of the experimental data. As the result, it was concluded that, in acetonitrile, the α/β equilibrium constants K are thermodynamically affected by steric hindrance from the 5′-hydroxy protecting group. On the other hand, the rate constants kα and kβ are mainly influenced by the stability of the oxonium ion intermediate. In particular, formation of an intramolecularly cyclized iminium ion intermediate from the oxonium ion intermediate, due to the neighboring group participation by the diethylthiocarbamoyl group, tended to decrease the overall reaction rate. Finally, the α/β C1′ epimerization could be carried out with a high α anomer selectivity of 89% through the use of the Et2CHC(O) group. Thus, 5′-O-pixyl-α-thymidine could be synthesized from β-thymidine as a key intermediate for the synthesis of α-DNA in a considerably improved overall yield of 40%.