gebhart/patrepeval huggingface dataset:
Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling (1993)

Previous studies have demonstrated that multichain immune recognition receptors, such as the T-cell receptor, signal their occupancy by inducing tyrosine phosphorylation of cellular protein substrates. Type I and II receptors for the Fc portion of IgG are single-chain immune recognition receptors having external, transmembrane, and cytoplasmic domains. In the present study, we have investigated the possibility that, upon engagement, Fc gamma receptors induce protein-tyrosine phosphorylation. Our findings reveal increased phosphorylation of a number of proteins on tyrosine residues after cross-linking of either high (Fc gamma RI) or low (Fc gamma RII) affinity receptors expressed on HL60 cells. Engagement of Fc gamma RII induced rapid tyrosine phosphorylation that decayed to basal levels by 40 min. In contrast, phosphorylation induced by Fc gamma RI cross-linking was more delayed, peaking at 5-10 min, and returning to basal levels by 60 min. Kinase assays of cellular proteins immunoprecipitated from lysates of activated cells by antibody to phosphotyrosine revealed phosphorylation of a 72-kDa molecule that was not present in lysates of resting cells. This phosphoprotein was identified as p72syk by immunoprecipitation with antibodies directed against two different regions of the syk gene product. Immunoprecipitation with antibodies against p72syk followed by immunoblotting with anti-phosphotyrosine antibodies revealed an activation-dependent tyrosine phosphorylation of p72syk. Thus, our present findings demonstrate induction of protein-tyrosine phosphorylation following engagement of monomeric immune recognition receptors and identify p72syk as a tyrosine kinase substrate involved in signaling by Fc gamma RI and Fc gamma RII.
Pathophysiology and management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (2020)

Background:  Epidermal necrolysis (EN) is an acute mucocutaneous reaction syndrome characterized by extensive necrosis and epidermal exfoliation and can cause death. The initial lesion is in the form of erythematous macules, then progressively grow to sagging blister lesion and subsequent epidermal peeling. The causes of SJS and TEN may vary such as infections, vaccinations, drugs, systemic diseases, and food. However, the main cause is the drug as found in many cases.  Methods:  The pathophysiology of the EN is still unclear. Pathologically, tissue damage in the form of epidermal necrolysis is a picture of mass keratinocyte cell death through apoptosis. The stimuli that can induce apoptosis include cellular stress, DNA damage and intracellular cytokines. It may as a result of the role of cytotoxic T cells against keratinocytes, through perforin-granzyme B or Fas-FasL interactions and granulysin. Another theory of SJS-TEN pathophysiology is the slow acetylation (drug metabolic disorder) and the theory of genetic susceptibility. Result:  Finally, we include a comprehensive review of well-established widely available therapies in SJS-TEN patients.  Discussion:  It requires rapid diagnosis, suspension of suspected drug as soon as possible, supportive therapy and specific therapy Conclusion:  An understanding of the pathophysiology and current management of SJS and TEN is expected to assist in the prevention of disease and early diagnosis and can provide more effective therapy for SJS-TEN treatment   Keywords:  Epidermal necrolysis, SJS-TEN, perforin-granzyme B, Fas-FasL interactions, granulysin
Network diagnosis by reasoning in uncertain nested evidence spaces (1995)

This paper describes a new diagnostic method and its application to communications network fault diagnosis. This new method uses belief propagation to accumulate evidence which it then uses for diagnosis. It has been successfully applied to the accurate, real-time diagnosis of break faults in large wide area data communications networks where the normal status messages provide very uncertain evidence of a fault and its location. It was tested on simulated WANs of up to 30000 monitored devices, including tests with either SNMP/PING or OSI monitoring, and also on a simulated WAN with an ATM/B-ISDN subnetwork. It achieved 99.96% accuracy in diagnosing 2499 out of 2500 break faults, making no extra false diagnoses, even though up to 127 devices were broken at once. Operational tests and trials were also carried out over which it achieved 99% accuracy. On both simulated and real networks it required approximately 1% of the CPU of a SUN SPARC 2 for every 15000 network devices monitored. It is now in operation in the network operations centre of a large, corporate WAN.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
On the Constitution of α-Tocopherol (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the Constitution of α-TocopherolE. FernholzCite this: J. Am. Chem. Soc. 1938, 60, 3, 700–705Publication Date (Print):March 1, 1938Publication History Published online1 May 2002Published inissue 1 March 1938https://doi.org/10.1021/ja01270a057RIGHTS & PERMISSIONSArticle Views296Altmetric-Citations113LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (645 KB) Get e-Alertsclose Get e-Alerts
Analysis of hCG: Clinical Applications and Assay Requirements (1998)

Study of the glycoprotein hormones, including hCG, is complex and evolving, and has benefited from recent major advances in analytical technology and molecular biology. It is important to be aware of the effect that these technological advances have, both on the analytical and the clinical requirements for provision of a diagnostic service for hCG. Some aspects of particular relevance are summarized in Table 10.
Multiple organ dysfunction syndrome pathogenesis and care: a complex systems’ theory perspective (2008)

Some of the principles of chaotic complex systems may need to be taken into account to advance care in MODS. An alternative theoretical perspective may support nurses to conceptualize both MODS and their role in a way that will help them to cope better with this devastating syndrome and develop practice.
Characterization of a COL1A1 splicing defect in a case of Ehlers-Danlos syndrome type VII: further evidence of molecular homogeneity. (1991)

A child affected by the type VII form of Ehlers-Danlos syndrome (EDS VII) was shown to have a heterozygous structural defect in the amino-terminus of pro-alpha 1(I) collagen. As a result, type I procollagen trimers containing defective subunits are not converted to mature collagen molecules. To identify the cause of the protein abnormality, specifically primed cDNAs and genomic DNA were PCR amplified and sequenced. This analysis disclosed that the protein structural defect is caused by a single base substitution (A for G) at position -1 of the splice donor site of intron 6 of the pro-alpha 1(I) collagen gene (COL1A1). The affected allele produces (a) transcripts lacking exon 6 sequences and (b), in lesser amount, normally spliced transcripts. Furthermore, the rate of exon 6 skipping is temperature dependent, for it appears to decrease substantially when the patient's fibroblasts are incubated at 31 degrees C. These findings are similar to those we previously reported for other unrelated EDS VII cases and, therefore, reemphasize the molecular homogeneity of this rare connective tissue disorder.
DynEST - Dynamically Explained Symbols for Traffic Or Learning How to Drive Without Words (2005)

Abstract: Traffic signs and rules play an important role in our daily life. Knowledge of them is crucial for surviving. However, every country has its own traffic regulations and they often differ in subtle ways. Also, the official traffic regulations are often rather hard to read and comprehend for the average person. In a time of globalization when more and more people live or travel abroad there is a growing need for a universal tool which would easily explain differences between the traffic regulations in various countries. Due to the internationality of such a tool, the choice of language represents a huge problem. In this paper we present DynEST, a unique software solution for this problem. DynEST explains traffic regulations without words, just using dynamic i.e. animated symbols. A simple yet powerful architecture of the software provides great flexibility for e.g. cross-comparing any two countries in the world. We hope that DynEST is a first step towards a European driving license and more security in traffic.
InTlSb: An infrared detector material? (1993)

In1−xTlxSb is proposed as promising infrared material. A number of optical and structural properties are studied within local density-functional theory. The alloy at x=0.09 is estimated to have a gap of 0.1 eV. Although TlSb is found to favor the CsCl structure, the zinc blende alloy is stable for low x values. A phase diagram is calculated to estimate the regions of stable phases and explore the conditions for growing narrow-gap In1−xTlxSb alloys.
Viterbi decoding with dual timescale traceback processing (2002)

A new approach to traceback processing in Viterbi decoders is presented. The approach reduces memory requirements as compared to previous approaches by using different speeds during acquisition of the best trellis path and the subsequent decoding of a block of data. This dual timescale approach allows in-place updating of the stored information and matches the constraints of commodity semi-custom technologies, where (at the considered high dock rates) write accesses to a RAM usually require more than one clock cycle.
A debugging tool for software evolution (2002)

Describes a tool for debugging programs which have been developed using evolutionary software techniques. The tool enhances the traditional debugging approach by automating the comparison of data structures between two running programs. Using this technique, it is possible to use early versions of a program which are known to operate correctly to generate values for comparison with the new program under development. The tool allows the reference code and the program being developed to execute on different computer systems by using open distributed systems techniques. A simple visualisation system allows the user to view the differences in data structures. By using the data flow of the code, it is possible to locate faulty sections of code rapidly. A small case study of finding an error in a scientific code is given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Organ Culture Corneal Storage at Ambient Room Temperature (1977)

• A simple Inexpensive method of organ culture corneal storage at ambient room temperature in which the media is never changed (closed system) has been developed. Human and cat corneas preserved in sealed heat-resistant culture tubes containing 50 ml of a modified Eagles minimum essential medium at ambient room temperature (22 to 24 C) retained active metabolism with adequate medium substrate and pH buffering for 7 to 12 days. Scanning and transmission electron microscopy revealed maintenance of an ultrastructurally intact endothelial layer for 6 to 7 days in human corneas and up to 14 days in cat corneas. Human endothelial function as measured by in vitro physiologic deturgescence capability was retained after up to 13 days storage. Good control of tissue sterility was achieved and observation of media clarity and pH (phenol red indicator) provided a check for microbial contamination. Closed system organ culture corneal storage at ambient room temperature provides several advantages as a method of corneal preservation. (<i>Arch Ophthalmol</i>95:869-878, 1977)
The Constitution of Corn Starch Dextrin<sup>1</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Constitution of Corn Starch Dextrin1J. D. Geerdes, Bertha A. Lewis, and F. SmithCite this: J. Am. Chem. Soc. 1957, 79, 15, 4209–4212Publication Date (Print):August 1, 1957Publication History Published online1 May 2002Published inissue 1 August 1957https://pubs.acs.org/doi/10.1021/ja01572a059https://doi.org/10.1021/ja01572a059research-articleACS PublicationsRequest reuse permissionsArticle Views147Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
TGF-β Utilizes SMAD3 to Inhibit CD16-Mediated IFN-γ Production and Antibody-Dependent Cellular Cytotoxicity in Human NK Cells (2008)

TGF-beta can be a potent suppressor of lymphocyte effector cell functions and can mediate these effects via distinct molecular pathways. The role of TGF-beta in regulating CD16-mediated NK cell IFN-gamma production and antibody-dependent cellular cytotoxicity (ADCC) is unclear, as are the signaling pathways that may be utilized. Treatment of primary human NK cells with TGF-beta inhibited IFN-gamma production induced by CD16 activation with or without IL-12 or IL-2, and it did so without affecting the phosphorylation/activation of MAP kinases ERK and p38, as well as STAT4. TGF-beta treatment induced SMAD3 phosphorylation, and ectopic overexpression of SMAD3 resulted in a significant decrease in IFN-gamma gene expression following CD16 activation with or without IL-12 or IL-2. Likewise, NK cells obtained from smad3(-/-) mice produced more IFN-gamma in response to CD16 activation plus IL-12 when compared with NK cells obtained from wild-type mice. Coactivation of human NK cells via CD16 and IL-12 induced expression of T-BET, the positive regulator of IFN-gamma, and T-BET was suppressed by TGF-beta and by SMAD3 overexpression. An extended treatment of primary NK cells with TGF-beta was required to inhibit ADCC, and it did so by inhibiting granzyme A and granzyme B expression. This effect was accentuated in cells overexpressing SMAD3. Collectively, our results indicate that TGF-beta inhibits CD16-mediated human NK cell IFN-gamma production and ADCC, and these effects are mediated via SMAD3.
T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis (2008)

Our data suggested that T-614 is an effective disease-modifying agent that can prevent bone/cartilage destruction and inflammation in in CIA rats. Combination with methotrexate markedly enhances the therapeutic effect of T-614.
Thermal Spray Powders-Cermet- (2003)

High velocity flame spraying, such as HVOF and HVAF, with cermet spray powders has recently come into wide use in the petrochemical, paper, automotive and steel industries, in addition to being a chrome plate alternative. The dernier great advance in cost and quality of the hard dense coatings with exceptional wear and corrosion protection has magnetism for everyone concerned in the field of surface modification including thermal spraying. It has been found that powder particle strength and grain size of ceramics, as well as particle size distribution and manufacturing route of cermet powders, have a great influence on the deposit efficiency and the property of the coatings. Furthermore, we have made it clear that the proper choice of substrates with harder surface is vital for increasing separation resistance of the coatings containing carbides. These contemporary points of view can enhance the quality of cermet coatings, which lead to the further prevalence of cermet powders using high velocity flame spraying.
Biased immunoglobulin light chain use in the <i>Chlamydophila psittaci</i> negative ocular adnexal marginal zone lymphomas (2013)

Ocular adnexal mucosa associated lymphoid tissue lymphomas (OAMALTL) are the most common lymphomas of the eye. The potential roles for specific antigens in these lymphomas are still controversial. Previously we examined IGHV usage and mutations in Chlamydophila (C) psittaci-negative OAMALTL, demonstrating biased use of the IGHV4 family and IGHV4-34 gene and evidence for antigen selection. Herein, we examined the IGKV/IGLV gene usage and mutations in 34 C. psittaci-negative OAMALTL originating from the orbit (15), conjunctivae (14), and lacrimal gland (5). Clonal potentially functional IGKV/IGLV gene sequences were identified in 30 tumors (18 kappa and 12 lambda). An overrepresentation of the IGKV4 family (P < 0.01) was observed. The IGKV3-20*01 allele was used at a greater frequency than in normal peripheral blood B-lymphocytes (P = 0.02) and commonly paired with the IGHV4-34 allele. Twenty-seven of the 30 unique light chain sequences displayed mutations from germline and evidence for antigen selection. Overall our findings demonstrate that in C. psittaci-negative OAMALTL there is a biased usage of IGKV families and genes, which harbor somatic mutations. These findings and the specific paring between the IGKV3-20*01 and IGHV4-34 alleles suggest that specific antigens could play an important role in the pathogenesis of these lymphomas.
Modified Kramers–Kronig Analysis of Optical Spectra (1971)

A modified Kramers–Kronig integral is derived, which offers greater convergence than the conventional expression when reflectance data are available over a limited range. The modified expression produces good convergence when applied to synthetic spectra.
Localization in Wireless Sensor Network through Constraint Satisfaction (2009)

To obtain a satisfactory performance in the wireless sensor network, optimal placement of sensors and routing is the most important aspect. In order to get optimal coverage in a given field for surveillance, we propose hexagonal cellular grid approach. The proposed approach is aimed at optimizing coverage and efficient placement of sensors under the constraints of number of sensors required, observe events of interest and communication between sensors. By computational geometry, specifically Voronoi Diagram and Delaunay Triangulation, we establish the main highlight of the paper – optimal placement of sensors and routing. Experimental results for an example sensor field demonstrate the application of our approach.
Distributed system loopshaping design of iterative control for batch processes (2003)

Presents a systematic approach to analysis and design of iterative learning control (ILC). A rigorous ILC design method is developed based on detailed specifications for performance, robustness, controller non-fragility, and control amplitude constraints. The designed ILC update is implementable through non-causal convolution window operators. The controller is designed by solving a linear quadratic optimization problem and manipulating control penalty weights. This is related in spirit to the LQG/LTR design method for dynamic controllers.
Wavelength Modulation for Background Correction in Graphite Furnace Atomic Emission Spectrometry (1976)

The use of wavelength modulation for background correction in graphite furnace atomic emission spectrometry is shown to improve detection limits in some cases by several orders of magnitude and to increase its applicability to sample analysis. An HGA-2100 graphite furnace atomizer is used in conjunction with a 3/4-m monochromator equipped for wavelength modulation. A discussion of analytical growth curves, detection limits, scatter, and optimization of signal/noise ratio is presented. Copper is analyzed in botanical samples and the results are compared to analysis by atomic absorption and molecular absorption spectrophotometry.
Effects of Medium Components on Shoot Formation from Cultured Tuber Discs of Potato1 (1980)

Abstract The effects of the components of Lam's 1977 potato nutrient medium on adventitious shoot formation were systematically evaluated. A low concentration (0.03 mg/liter) of naphthaleneacetic acid (NAA) stimulated shoot initiation and increased survival of tuber discs of potato ( Solanum tuberosum L.). Indoleacetic acid (IAA), however, did not affect shoot initiation in the concentration range from 0 to 10 mg/liter. Both 6-benzyl-amino purine (BA) at 0.3, 1.0, and 3.0 mg/liter and N 6 -(4-hydroxy-3-methyl-but-2-enylamino)-purine (zeatin) at 0.3 and 1.0 mg/liter stimulated adventitious shoot formation while N 6 -furfurylaminopurine (kinetin) had no effect. Sucrose was essential for shoot formation with a concentration of 30 g/liter being optimal. Although not essential, i -inositol enhanced the initiation of adventitious shoots at concentrations of 60 and 100 mg/liter. Casein hydrolysate and additional inorganic phosphate had no promotive effect on shoot formation and adenine sulfate was inhibitory at all concentrations examined.
Learning to aggregate vertical results into web search results (2011)

Aggregated search is the task of integrating results from potentially multiple specialized search services, or verticals, into the Web search results. The task requires predicting not only which verticals to present (the focus of most prior research), but also predicting where in the Web results to present them (i.e., above or below the Web results, or somewhere in between). Learning models to aggregate results from multiple verticals is associated with two major challenges. First, because verticals retrieve different types of results and address different search tasks, results from different verticals are associated with different types of predictive evidence (or features). Second, even when a feature is common across verticals, its predictiveness may be vertical-specific. Therefore, approaches to aggregating vertical results require handling an inconsistent feature representation across verticals, and, potentially, a vertical-specific relationship between features and relevance. We present 3 general approaches that address these challenges in different ways and compare their results across a set of 13 verticals and 1070 queries. We show that the best approaches are those that allow the learning algorithm to learn a vertical-specific relationship between features and relevance.