gebhart/patrepeval huggingface dataset:
A new idea of using one-dimensional PWL map in digital secure communications-dual-resolution approach (2000)

In this brief, a new approach of using 1-D map in digital chaotic encryption systems is presented. This scheme utilizes a class of 1-D piecewise linear (PWL) map with different discretization on its input and output terminals to realize finite-precision chaotic encryption and decryption systems through the inverse system approach. This kind of map has the property of different discrete-value sets on its input and output terminals, and is called a dual-resolution map. The general structure of encryption systems that utilize a dual-resolution map is proposed, in which a dynamical system /spl Sigma/(/spl middot/) is used to connect the n-order delay line with the input terminal of the dual-resolution map. An example encoder with a four-order delay line is given to promote an understanding of the performance of this new type nonlinear digital encryption system. Simulation results shows that the zero-response of the encoder has a d-like auto-correlation function and the response sequences converge to cyclic sequences with long period. The decoder (inverse system of the encoder) is sensitive to all parameter mismatches, so it can provide high security of the encrypted signals and can be used in real-time digital secure communications when high security is needed.
Voltammetric Electrode Based on Nafion and Poly(2,3–dihydrothieno–1,4–dioxin)–poly(styrenesulfonate) Film for Fast and High Sensitive Determination of Metamizole (2016)

A rapid and high sensitive method of metamizole determination was successfully developed at glassy carbon electrode modified with Nafion/PEDOT:PSS film using linear sweep voltammetry in phosphate buffer at pH 3.0. The electrochemical behavior of the modified electrode and electrooxidation of metamizole was investigated using cyclic voltammetry. A linear voltammetric response for analyte was obtained in the concentration range from 0.1 μmol L−1 (33.3 μg L−1) to 13 μmol L−1 (4.33 mg L−1), with a detection limit of 0.02 μmol L−1 for preconcentration time of 90 s. Repeatability of method was determined as RSD % for metamizole concentration of 0.5 μmol L−1 as 2.2% for n = 9. The proposed method was successfully applied for determination of metamizole in various pharmaceuticals products. The method was validated by studying the recovery from spiked urine and tablets samples. Proposed metamizole determination method is simple, short and does not require large financial outlays.
Molecular cloning and sequence analysis of an isolate of hepatitis C virus from Southern California, U.S.A. (1992)

We obtained a cDNA clone representing a partial RNA sequence of a human hepatitis C virus (HCV) isolate from Southern California. RNA was extracted from the liver tissue of a patient with post-transfusion hepatitis, and used for cDNA synthesis and polymerase chain reaction (PCR) amplification using oligonucleotide primers specific for the prototype HCV RNA. The cDNA clone obtained contains 585 base pairs of HCV sequences and represents the region encoding the putative nonstructural protein NS3 of HCV. Sequence analysis of this clone showed that it shares 93.8%, 78.7% and 79.6% similarity, respectively, with the previously published American, Japanese and Taiwanese isolates at the nucleotide level, indicating the heterogeneity of HCV RNA in different geographic areas. By contrast, it shares 97.3%, 92.9% and 92.9% with these respective isolates at the amino acid level, suggesting the functional conservation of viral genes.
Parallelization in Scientific Workflow Management Systems (2013)

Over the last two decades, scientific workflow management systems (SWfMS) have emerged as a means to facilitate the design, execution, and monitoring of reusable scientific data processing pipelines. At the same time, the amounts of data generated in various areas of science outpaced enhancements in computational power and storage capabilities. This is especially true for the life sciences, where new technologies increased the sequencing throughput from kilobytes to terabytes per day. This trend requires current SWfMS to adapt: Native support for parallel workflow execution must be provided to increase performance; dynamically scalable "pay-per-use" compute infrastructures have to be integrated to diminish hardware costs; adaptive scheduling of workflows in distributed compute environments is required to optimize resource utilization. In this survey we give an overview of parallelization techniques for SWfMS, both in theory and in their realization in concrete systems. We find that current systems leave considerable room for improvement and we propose key advancements to the landscape of SWfMS.
Exploring collections of 3D models using fuzzy correspondences (2012)

Large collections of 3D models from the same object class (e.g., chairs, cars, animals) are now commonly available via many public repositories, but exploring the range of shape variations across such collections remains a challenging task. In this work, we present a new exploration interface that allows users to browse collections based on similarities and differences between shapes in user-specified regions of interest (ROIs). To support this interactive system, we introduce a novel analysis method for computing similarity relationships between points on 3D shapes across a collection. We encode the inherent ambiguity in these relationships using fuzzy point correspondences and propose a robust and efficient computational framework that estimates fuzzy correspondences using only a sparse set of pairwise model alignments. We evaluate our analysis method on a range of correspondence benchmarks and report substantial improvements in both speed and accuracy over existing alternatives. In addition, we demonstrate how fuzzy correspondences enable key features in our exploration tool, such as automated view alignment, ROI-based similarity search, and faceted browsing.
Pressure-sensitive adhesive properties of wheat flour dough and the influence of temperature, separation rate, and moisture content (1994)

Using the method of reduced variables, probe tack test data on wheat flour-water doughs was shifted into a series of master curves. This illustrated the equivalent influence of increasing temperature, increasing moisture content, and decreasing separation rate on adhesive behavior. An adhesive-cohesive failure transition occurred at 25-30 o C (43% moisture content). This transition occurs 50-70 o C above the T g of a pressure-sensitive adhesive and is associated with a shift in viscoelastic behavior from the rubbery state (entanglement network present) to the flow state (entanglement network disappears due to slippage). Low molecular weight plasticizers (such as water) shift the location of the rubbery-flow state transition to lower temperatures and faster rates. Thus, as the moisture content of the dough increased, the adhesive-cohesive failure transition shifted to lower temperatures and faster separation rates. Processors could prevent cohesive failure, and thus a residue-buildup on equipment, by changing either the formulations or the processing rate-temperature conditions to favor the adhesive side of the failure transition zone
The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex (2000)

A requirement for scaffolding complexes containing internalized G protein-coupled receptors and beta-arrestins in the activation and subcellular localization of extracellular signal-regulated kinases 1 and 2 (ERK1/2) has recently been proposed. However, the composition of these complexes and the importance of this requirement for function of ERK1/2 appear to differ between receptors. Here we report that substance P (SP) activation of neurokinin-1 receptor (NK1R) stimulates the formation of a scaffolding complex comprising internalized receptor, beta-arrestin, src, and ERK1/2 (detected by gel filtration, immunoprecipitation, and immunofluorescence). Inhibition of complex formation, by expression of dominant-negative beta-arrestin or a truncated NK1R that fails to interact with beta-arrestin, inhibits both SP-stimulated endocytosis of the NK1R and activation of ERK1/2, which is required for the proliferative and antiapoptotic effects of SP. Thus, formation of a beta-arrestin-containing complex facilitates the proliferative and antiapoptotic effects of SP, and these effects of SP could be diminished in cells expressing truncated NK1R corresponding to a naturally occurring variant.
Secrecy gain: A wiretap lattice code design (2010)

We propose the notion of secrecy gain as a code design criterion for wiretap lattice codes to be used over an additive white Gaussian noise channel. Our analysis relies on the error probabilites of both the legitimate user and the eavesdropper. We focus on geometrical properties of lattices, described by their theta series, to characterize good wiretap codes.
mTOR Inhibitor Everolimus in Regulatory T Cell Expansion for Clinical Application in Transplantation (2018)

Our results support the feasibility of EVR to expand functionally competent Treg cells for their clinical use.
A Novel Direct-Drive Dual-Structure Permanent Magnet Machine (2010)

By incorporating the merits of fractional-slot concentrated windings and Vernier machine structure, a new multi-pole dual-structure permanent magnet (PM) machine is proposed for low speed, direct-drive applications in this paper. In the outer stator, a fractional-slot concentrated winding is adopted to reduce the slot number and stator yoke height, hence saving space and improving torque density. In the inner stator, a Vernier structure is used to reduce the winding slots, thereby enlarging the slot area to accommodate more conductors, thus the inner stator space is fully utilized. Consequently, the merits of these two structures can be ingeniously integrated into one compact PM machine and the torque density is improved, cogging torque is reduced and the control flexibility with two sets of independent stator windings is increased. By using time-stepping finite element method with curvilinear elements for moving between the stator and the rotor, the steady state and transient performances of the PM machine are simulated and the validity of proposed dual-structure PM machine is verified.
Fast motion estimation using circular zonal search (1998)

Block based motion estimation is widely used for exploiting temporal correlation within an image. Still the full search algorithm, which is considered to be the optimal, is computational intensive. In this paper a new fast motion estimation method for video coding, is presented. It will be shown that the new algorithm is not only much faster than traditional algorithms, but in some cases can achieve much better visual quality, even from the &quot;optimal&quot; full search algorithm.
Standards of care for treatment of recurrent glioblastoma—are we there yet? (2012)

Newly diagnosed glioblastoma is now commonly treated with surgery, if feasible, or biopsy, followed by radiation plus concomitant and adjuvant temozolomide. The treatment of recurrent glioblastoma continues to be a moving target as new therapeutic principles enrich the standards of care for newly diagnosed disease. We reviewed PubMed and American Society of Clinical Oncology abstracts from January 2006 to January 2012 to identify clinical trials investigating the treatment of recurrent or progressive glioblastoma with nitrosoureas, temozolomide, bevacizumab, and/or combinations of these agents. At recurrence, a minority of patients are eligible for second surgery or reirradiation, based on appropriate patient selection. In temozolomide-pretreated patients, progression-free survival rates at 6 months of 20%-30% may be achieved either with nitrosoureas, temozolomide in various dosing regimens, or bevacizumab. Combination regimens among these agents or with other drugs have not produced evidence for superior activity but commonly produce more toxicity. More research is needed to better define patient profiles that predict benefit from the limited therapeutic options available after the current standard of care has failed.
The design of ethernet-based distributed interpolator (2008)

The lack of synchronous communication channel is a major obstacle for the application Ethernet to the motion control systems. Based on the IEEE-1588 precision clock synchronization protocol, in this paper, a new distributed interpolator have been studied. The PVT-based distributed interpolation scheme that only relies on a clock synchronization of Ethernet can achieve accurate synchronization between servo controllers without synchronous communication.
Interactive multiresolution mesh editing (1997)

We describe a multiresolution representation for meshes based on subdivision, which is a natural extension of the existing patch-based surface representations. Combining subdivision and the smoothing algorithms of Taubin [26] allows us to construct a set of algorithms for interactive multiresolution editing of complex hierarchical meshes of arbitrary topology. The simplicity of the underlying algorithms for refinement and coarsification enables us to make them local and adaptive, thereby considerably improving their efficiency. We have built a scalable interactive multiresolution editing system based on such algorithms.
Molecular Dynamics Simulation on Stability of Insulin on Graphene (2009)

The adsorption dynamics of a model protein (the human insulin) onto graphene surfaces with different sizes was investigated by molecular dynamics simulations. During the adsorption, it has different effect on the stability of the model protein in the fixed and non-fixed graphene systems. The tertiary structure of the protein was destroyed or partially destroyed, and graphene surfaces shows the selective protection for some -helices in non-fixed systems but not in fixed systems by reason of the flexibility of graphene. As indicated by the interaction energy curve and trajectory animation, the conformation and orientation selection of the protein were induced by the properties and the texture of graphene surfaces. The knowledge of protein adsorption on graphene surfaces would be helpful to better understand stability of protein on graphene surfaces and facilitate potential applications of graphene in biotechnology.
The Zone Diet Phenomenon: A Closer Look at the Science behind the Claims (2003)

The purported health benefits of low-carbohydrate diets have been advocated intermittently over the last century and have enjoyed increasing popularity over the last decade. Although most revolve around the emphatic theme that carbohydrates are to blame for many chronic diseases, their specific ideologies are more variable and in some cases quite sophisticated. The Zone Diet phenomenon represents a new generation of modern low carbohydrate food fad with sales placing it among the most popular diet books in recent history. The Zone is a 40% carbohydrate, 30% protein and 30% fat eating plan that advocates only sparing use of grains and starches. The precise 0.75 protein to carbohydrate ratio required with each meal is promoted to reduce the insulin to glucagon ratio, which purportedly affects eicosanoid metabolism and ultimately produces a cascade of biological events leading to a reduction in chronic disease risk, enhanced immunity, maximal physical and mental performance, increased longevity and permanent weight loss. There is presently little scientific support for the connections made between diet, endocrinology and eicosanoid metabolism. In fact, a review of the literature suggests that there are scientific contradictions in the Zone Diet hypothesis that cast unquestionable doubt on its potential efficacy. The purpose of this review is to evaluate the scientific merit of the Zone Diet and its health claims in an effort to help delineate what is and what is not sound nutrition science.
Single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis (2020)

We propose that the frequency of CD3-CD7+GZMB+ in peripheral blood could be used as a novel biomarker for distinguishing TB from LTBI and HC. FUND: The study was supported by Natural Science Foundation of China (81770013, 81525016, 81772145, 81871255 and 91942315), National Science and Technology Major Project (2017ZX10201301), Science and Technology Project of Shenzhen (JCYJ20170412101048337) and Guangdong Provincial Key Laboratory of Regional Immunity and Diseases (2019B030301009). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
High gradient magnetic separation of yeast (1991)

High gradient magnetic separation (HGMS) is used to separate nonmagnetic microorganisms from solution by a technique known as seeding. Fine magnetic particles are adhered to the cells' surfaces, making them magnetic and amenable to magnetic separation. Attachment of the sub-micron, acicular gamma-Fe(2)O(3) seed to the yeast surface occurs irrespective of the solution pH and surface charge and is essentially irreversible. A model is developed to predict the separation of yeast in a high gradient magnetic separator. The effective capture radius is assumed to be proportional to the derived magnetic parameter gamma for the case where the dominant competing force to magnetic attraction is the magnetic floc's inertia. Using this parameter, yeast separation in an HGMS unit is predicted. The measured separation of Saccharomyces cerevisiae at differing magnetic seed concentrations and two flow rates supports the above model.
Methods for determining topography in data sparse regions of East Antarctica (2007)

Large regions of East Antarctica lack a reasonable topographic model because, until recently, only a few observations of ice thickness have been available to constrain the bedrock elevation. The acquisition of GRACE satellite gravity data has created a new opportunity to model the sub-ice topography. Here we have applied two methods for predicting topography based on the satellite data. Gravity inversion is a classical geophysical technique that predicts topography based on the physics relating it to gravity. Cokriging is a statistical method that uses the spatial covariance between datasets to predict one in the absence of the other. The geophysical and statistical solutions are compared to the best-known topography model (BEDMAP) in an area that is relatively well constrained by the BEDMAP data coverage.
Peroxidase Activity in Heme Proteins Derived from a Designed Combinatorial Library (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTPeroxidase Activity in Heme Proteins Derived from a Designed Combinatorial LibraryDavid A. Moffet, Laura K. Certain, Allison J. Smith, Adam J. Kessel, Katharine A. Beckwith, and Michael H. HechtView Author Information Department of Chemistry, Princeton University Princeton, New Jersey 08544-1009 Cite this: J. Am. Chem. Soc. 2000, 122, 31, 7612–7613Publication Date (Web):July 21, 2000Publication History Received6 April 2000Published online21 July 2000Published inissue 1 August 2000https://pubs.acs.org/doi/10.1021/ja001198qhttps://doi.org/10.1021/ja001198qrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views894Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Bioinorganic chemistry,Genetics,Kinetics,Monomers,Peptides and proteins Get e-Alerts
Preparation and application of anti-HBx/anti-CD3 bispecific monoclonal antibody (BsAb) retargeting effector cells for lysis of human hepatoma xenografts in nude mice (1996)

Evidence indicated that the x gene of human HBV can cause cancer in transgenic mice, moreover, HBxAg was so far the most frequent and strong antigen among those HBV markers expressed in hepatocellular carcinoma (HCC) tissues. Aiming to enhance killing of HCC by effector cells, we established an anti-HBx/anti-CD3 hybrid-hybridomas by fusion of anti-HBx hybridoma cells with FITC-labeled anti-CD3 HAT sensitive cells, and followed by FACStar sterile cell sorting, HAT selection and eventually verified by ELISA and double bridging assay. Using two color cytometric analysis, we found that bispecific monoclonal antibody (BsAb) remarkably enhanced in vitro effector-target cell conjugates (48.3% vs. 8.5%). In in vivo study, BsAb retargeting effector cells were significantly more effective than that of effector cells alone in shrinkage of LTNM4 HCC xenografts (HBxAg positive) in nude mice, not only in fresh inoculated tumors but also in established tumors (p<0.01, p<0.01, respectively). Besides, pronounced apoptotic cell death and infiltration of lymphocytes in the peripheral of tumor nodules can also be witnessed in the tissues treated by BsAb plus effector cells, but not in the controls. The results demonstrated that antiHBx/anti-CD3 BsAb was able to redirect effector cells for lysis of HBxAg positive HCC cells both in vitro and in vivo and it also indicated that shrinkage of tumors in nude mice with therapy of BsAb retargeting effector cells was partially due to initiation of apoptotic cell death.
CASAS: A Smart Home in a Box (2012)

While the potential benefits of smart home technology are widely recognized, a lightweight design is needed for the benefits to be realized at a large scale. We introduce the CASAS "smart home in a box", a lightweight smart home design that is easy to install and provides smart home capabilities out of the box with no customization or training. We discuss types of data analysis that have been performed by the CASAS group and can be pursued in the future by using this approach to designing and implementing smart home technologies.