gebhart/patrepeval huggingface dataset:
Integrated sources of photon quantum states based on nonlinear optics (2017)

The ability to generate complex optical photon states involving entanglement between multiple optical modes is not only critical to advancing our understanding of quantum mechanics but will play a key role in generating many applications in quantum technologies. These include quantum communications, computation, imaging, microscopy and many other novel technologies that are constantly being proposed. However, approaches to generating parallel multiple, customisable bi- and multi-entangled quantum bits (qubits) on a chip are still in the early stages of development. Here, we review recent advances in the realisation of integrated sources of photonic quantum states, focusing on approaches based on nonlinear optics that are compatible with contemporary optical fibre telecommunications and quantum memory platforms as well as with chip-scale semiconductor technology. These new and exciting platforms hold the promise of compact, low-cost, scalable and practical implementations of sources for the generation and manipulation of complex quantum optical states on a chip, which will play a major role in bringing quantum technologies out of the laboratory and into the real world.
Synthesis and Biological Evaluation of 14‐Alkoxymorphinans Part 4 opioid agonists and partial opioid agonists in a series of <i>N</i>‐(cyclobutylmethyl)‐14‐methoxymorphinan‐6‐ones (1989)

Abstract The N ‐(cyclobutylmethyl)morphinans 12 , 19 , 20 , 21 , 27 , and 29 and the N ‐(2‐cyanoethyl) analogue 33 were prepared from different precursors. Pharmacological evaluation ( e.g. opioid receptor binding assays, acetic‐acid writhing test, hot‐plate assay) points to a partial opioid agonism of compounds 12 , 27 , 29 , and 33 , and to full opioid agonism of compounds 19 – 21 .
High-Isotropic Magnetic Sensor Based on Ring Terfenol-D/PZT Composites (2018)

In this paper, we study the isotropic properties of a ring-shaped magnetoelectric composites made of Terfenol-D and PZT-5H. We presented a theoretical model to estimate the output via areal strain considering the effect of magnetic hysteresis. Test samples were prepared by stacking and bonding together both the ring-shaped magnetostrictive material, Terfenol-D, and the piezoelectric material, PZT-5H. The results show that the magnetoelectric composites have an ac resonant frequency <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$f_{\mathrm {ac}}$ </tex-math></inline-formula> of about 32 kHz. When the dc bias magnetic field <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$H_{\mathbf {dc}} = 280$ </tex-math></inline-formula> Oe and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$f_{\mathrm {ac}} = 32$ </tex-math></inline-formula> kHz, the linear fit of the relation between the output and the ac magnetic field provides a high coefficient of determination (R-square = 0.95), and the magnetoelectric voltage coefficient is 4.28 V/ <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text {cm}\cdot \text {Oe}$ </tex-math></inline-formula> . These values indicate a good linear relationship, thus confirming that the composites present the basic performance of a magnetic sensor. The isotropic properties of the sample were fitted with the curve obtained from the theory. The results show that the isotropic ratio is theoretically equal to 7:1 at a resonant frequency of 32 kHz, which keeps highly consistent with test data. The coefficient of determination (R-square = 0.94) between the test data and calculated values confirms the goodness of the fit, thus indicating the correctness and reliability of the theoretical model. The model presented in this paper provides a theoretical basis to analyze and improve the isotropic properties of magnetoelectric sensors.
Light Management in Upconverting Nanoparticles: Ultrasmall Core/Shell Architectures to Tune the Emission Color (2014)

Ultrasmall NaGdF4 nanoparticles with core/shell and core/shell/shell architectures have been synthesized following a microwave-based thermolysis procedure, allowing us to rapidly obtain homogeneous nanoparticles compared to conventional heating. To analyze the possibilities of the proposed structure in terms of tuning the emission color, core and shells have been doped with different lanthanide ion pairs (either Er3+/Yb3+ and/or Tm3+/Yb3+), keeping them therefore spatially separated inside the different layers of the nanoparticles. Here, we demonstrate that the position of the dopants inside the nanoparticles affects the intensity of the different emission bands of the luminescing Tm3+ and Er3+ ions and show how it has a relevant effect on the overall emission color of the luminescence obtained after 975 nm excitation.
Systematic Design of Supply Regulated <i>LC</i>-Tank Voltage-Controlled Oscillators (2008)

Systematic design of low-dropout-regulator (LDO) regulated low-phase-noise LC-tank voltage controlled oscillators (VCOs) is presented. Low-frequency sensitivity profile of power supply induced phase noise of a typical cross-coupled LC-tank VCO is investigated. The relationship between frequency pushing and power supply-induced phase noise is derived. Systematic codesign of VCO sensitivity to low-frequency supply noise with respect to an LDO output noise and power supply rejection profile is introduced. To demonstrate the design approach experimentally, two 2.4-GHz LC-tank VCOs with pMOS and nMOS switching devices powered by PFET LDOs are designed and fabricated on an 0.18-mum, 7-layer metal CMOS process. By using an integrated LDO, it is shown that the VCO phase-noise sensitivity to low frequency improves by 55 dB at 100-kHz offset.
Neurodevelopment and Cognition in Children after Enterovirus 71 Infection (2007)

Enterovirus 71 infection with CNS involvement and cardiopulmonary failure may be associated with neurologic sequelae, delayed neurodevelopment, and reduced cognitive functioning. Children with CNS involvement without cardiopulmonary failure did well on neurodevelopment tests. (ClinicalTrials.gov number, NCT00172393 [ClinicalTrials.gov].).
Design and implementation of smart garage- An IoT perspective (2017)

Internet of Things is a burgeoning field in the world of technology. It helps ease life for a person by means of internetworking physical devices, automotive, home appliances and other items embedded with electronics, software, sensors and actuators. Smart garage is one such device that helps ease the access of the garage doors in domestic use. Unlike most solutions, smart garage help you to access your doors with the help of a computable device such as smart phones or tablets connected to a network, and access by means of secured pins to authorize the access. We designed one such garage using Arduino web server, and a smartphone. Which we compared with existing methods. We have illustrated the building process of the setup for the prototype of our garage, and various means to improve power consumptions and alternate methods for a secured pin.
An optimum design for 3-D fixture synthesis in a point set domain (2000)

Addresses the problem of fixture synthesis for 3-D workpieces with a set of discrete locations on the workpiece surface as a point set of candidates for locator and clamp placement. A sequential optimization approach is presented in order to reduce the complexity associated with an exhaustive search. The approach is based on a concept of optimum experimental design, while the optimization focuses on the fixture performance of workpiece localization accuracy. In using the D-optimality criterion to minimize the workpiece positioning errors, two different greedy algorithms are developed for force-closure fixturing in the point set domain. Both 2-D and 3-D examples are presented to illustrate the effectiveness of the synthesis approach.
Femtosecond laser writing of Bragg grating waveguide bundles in bulk glass (2015)

Waveguide bundles in bulk glass materials, consisting of several parallel scans of refractive index modifications, have been generated with a low-repetition femtosecond laser. Additionally, Bragg grating (BG) structures for 840 and 1550 nm have been introduced by segmentation of the central scan. A spectral loss in the transmission signal of >36 dB was achieved at 1550 nm with a second-order Bragg grating waveguide (BGW) in fused silica, which corresponds to an intrinsic grating efficiency of >16 dB/cm. This is to our knowledge the strongest BG structure realized in glass with a femtosecond laser. The BGW were proven to be stable up to a temperature of 250°C in fused silica. The diameter of the waveguide bundles can be adapted very easily for a broad range of wavelengths and have been demonstrated for diameters between 1 and 50 μm. The transmission properties of the waveguide bundles are affected minorly by the insertion of BG structures, which opens the ability for adjusting the BGW for a broad range of wavelength in single-mode or multimode optical circuits. BGW have been realized successfully in fused silica, borosilicate glass (BOROFLOAT 33), and AF 32 eco Thin Glass from Schott.
Design and Preliminary Results of a Prototype HTS SMES Device (2005)

The University of Wollongong (UOW) has developed the design for a 20 kJ high transition temperature Superconducting Magnetic Energy Storage (SMES) device, and constructed a nominally 2.5 kJ prototype. The coil for the prototype was wound using High Temperature Superconducting (HTS) BSCCO-2223 tape. It was refrigerated to 20 K using a gaseous helium cold head cryocooler. The SMES device has been constructed as a prototype for a larger commercially realizable system, and hence is capable of supplying a 3-phase load during voltage sags or short (<1 s) power interruptions. This paper discusses the modeling and design of the electromagnetic and thermal aspects of the coil, the Power Control Circuit (PCC), current leads and cryogenic system. Also presented are preliminary results of the SMES coil, cryogenics, and system energy storage and delivery capabilities.
Selective growth inhibition of human lung cancer cell lines bearing a surface glycoprotein gp160 by 125I-labeled anti-gp160 monoclonal antibody. (1988)

Monoclonal antibody 5E8 which is specific for a Mr 160,000 glycoprotein (gp160) on the surface of human lung cancer was radiolabeled with 125I. Radiolabeled 5E8 antibody is shown here to suppress the growth of gp160 positive human lung tumor cell lines in a dose-dependent fashion, but this same radiolabeled antibody does not alter the growth of gp160 negative lung tumor cell lines. Neither the unlabeled 5E8 nor a control radiolabeled monoclonal antibody has any effect upon the growth of gp160 positive tumors. The specificity of radiolabeled antibody mediated tumor killing is further demonstrated by the ability of unlabeled 5E8 to inhibit tumor killing by 125I-5E8. The efficiency with which the labeled tumor specific antibody suppressed tumor colony formation is enhanced by increasing the molar ratio of 125I to 5E8. This ratio could be increased to a level of two without affecting the capacity of the antibody to bind to the cell surface antigen. An attempt to increase the efficiency of tumor killing by the addition of a second antibody subsequent to incubation with 125I-5E8 was unsuccessful. These results indicate that 125I is a viable isotope and gp160 represents an appropriate target for radioimmunotherapy of human lung cancer.
Frequent overexpression of multiple ErbB receptors by head and neck squamous cell carcinoma contrasts with rare antibody immunity in patients (2004)

In an effort to elucidate the role of ErbB receptors in human head and neck squamous cell carcinoma (HNSCC), expression abnormalities and subcellular localization of epidermal growth factor receptor (EGFR), ErbB2, ErbB3, and ErbB4 were investigated along with EGF and tenascin by immunohistochemistry in 38 carcinomas as compared to adjacent normal mucosa of 24 cases. Although tumour-specific overexpression affected each ErbB receptor (EGFR 47%, ErbB2 29%, ErbB3 21%, ErbB4 26%), EGFR abnormalities were most prevalent. The latter, and overexpression of more than two ErbB receptors in the same tumour, which always included EGFR, correlated with metastatic disease. ErbB products were specifically detected on the cell membrane and in the cytoplasm. In contrast, ErbB4 was uniquely localized to the nucleus in 7 carcinomas and a tumour-derived cell line, indicating a role for regulated intramembrane proteolysis resulting in nuclear ErbB4 translocation in HNSCC. Expression of prototype ligand EGF or low-affinity stromal activator tenascin correlated significantly with EGFR overexpression, implying chronic EGFR activation. Simultaneous overexpression of additional ErbB receptors in most of these cases suggested recurrent involvement of receptor heterodimers. In spite of frequent ErbB receptor alterations, autologous ErbB serum antibodies were rare, with only 1 of 38 tumour patients exhibiting an ErbB2-specific immune response. Based on upregulation of several known immunosuppressive molecules, scarcity of ErbB-specific antibodies is consistent with attenuation of natural tumour-specific immune responses in HNSCC.
Einspritzmengenkorrektur in Common-Rail-Systemen mit Hilfe magnetoelastischer Drucksensoren (2006)

Bei Common-Rail-Motoren entstehen im Einspritzsystem Druckschwingungen, die die Kraftstoffmenge bei Mehrfacheinspritzungen verfälschen, was die entstehenden Emissionen nachhaltig verschlechtert.\n\t\t\t\t\tIn dieser Arbeit wird ein neues Verfahren zur Korrektur der Einspritzmengen vorgestellt.
Robustness of quantum key distribution with discrete and continuous variables to channel noise (2017)

We study the robustness of quantum key distribution protocols using discrete or continuous variables to the channel noise. We introduce the model of such noise based on coupling of the signal to a thermal reservoir, typical for continuous-variable quantum key distribution, to the discrete-variable case. Then we perform a comparison of the bounds on the tolerable channel noise between these two kinds of protocols using the same noise parametrization, in the case of implementation which is perfect otherwise. Obtained results show that continuous-variable protocols can exhibit similar robustness to the channel noise when the transmittance of the channel is relatively high. However, for strong loss discrete-variable protocols are superior and can overcome even the infinite-squeezing continuous-variable protocol while using limited nonclassical resources. The requirement on the probability of a single-photon production which would have to be fulfilled by a practical source of photons in order to demonstrate such superiority is feasible thanks to the recent rapid development in this field.
Biological and Clinical Significance of MAD2L1 and BUB1, Genes Frequently Appearing in Expression Signatures for Breast Cancer Prognosis (2015)

To investigate the biologic relevance and clinical implication of genes involved in multiple gene expression signatures for breast cancer prognosis, we identified 16 published gene expression signatures, and selected two genes, MAD2L1 and BUB1. These genes appeared in 5 signatures and were involved in cell-cycle regulation. We analyzed the expression of these genes in relation to tumor features and disease outcomes. In vitro experiments were also performed in two breast cancer cell lines, MDA-MB-231 and MDA-MB-468, to assess cell proliferation, migration and invasion after knocking down the expression of these genes. High expression of these genes was found to be associated with aggressive tumors and poor disease-free survival of 203 breast cancer patients in our study, and the association with survival was confirmed in an online database consisting of 914 patients. In vitro experiments demonstrated that lowering the expression of these genes by siRNAs reduced tumor cell growth and inhibited cell migration and invasion. Our investigation suggests that MAD2L1 and BUB1 may play important roles in breast cancer progression, and measuring the expression of these genes may assist the prediction of breast cancer prognosis.
Combinatorially Designed Lipid‐like Nanoparticles for Intracellular Delivery of Cytotoxic Protein for Cancer Therapy (2014)

Abstract An efficient and safe method to deliver active proteins into the cytosol of targeted cells is highly desirable to advance protein‐based therapeutics. A novel protein delivery platform has been created by combinatorial design of cationic lipid‐like materials (termed “lipidoids”), coupled with a reversible chemical protein engineering approach. Using ribonuclease A (RNase A) and saporin as two representative cytotoxic proteins, the combinatorial lipidoids efficiently deliver proteins into cancer cells and inhibit cell proliferation. A study of the structure–function relationship reveals that the electrostatic and hydrophobic interactions between the lipidoids and the protein play a vital role in the formation of protein–lipidoid nanocomplexes and intracellular delivery. A representative lipidoid (EC16‐1) protein nanoparticle formulation inhibits cell proliferation in vitro and suppresses tumor growth in a murine breast cancer model.
Degradation of alpha‐melanocyte stimulating hormone (alpha‐MSH) by CALLA/endopeptidase 24. 11 expressed by human melanoma cells in culture (1990)

The common acute lymphoblastic leukemia antigen (CALLA) is identical to human endopeptidase 24.11 (E-24.11) and is expressed on certain human melanoma lines. This work was conducted in order to investigate whether alpha-melanocyte-stimulating hormone (alpha-MSH) could be a substrate for E-24.11, its degradation leading to the negative alpha-MSH radiobinding assay results observed with some CALLA-positive cell lines. We used 3 human melanoma cell lines (GLL-19, Mel Juso and G361) which lack receptors to alpha-MSH and express CALLA, and, as a control, one CALLA-negative melanoma cell line (HBL) with specific receptors for alpha-MSH. Radioimmunoassays give evidence that alpha-MSH was degraded in the presence of the 4 melanoma cell lines and that disappearance of the peptide was significantly reduced by phosphoramidon in 2 lines (GLL-19 and G361). Upon incubation of alpha-MSH with GLL-19 and G361 cell membranes, 3 degradation products were completely abolished in the presence of phosphoramidon. Amino acid content analysis of alpha-MSH fragments produced by purified E-24.11 permitted identification of 6 peptide bonds in the sequence of alpha-MSH susceptible to cleavage by the enzyme. It is concluded that alpha-MSH is a substrate in vitro for purified E-24.11 and for the enzyme present on the human melanoma cell lines GLL-19 and G361, expressing a high level of endopeptidase activity. However, hydrolysis of alpha-MSH by this enzyme does not seem to represent the main factor responsible for the apparent absence of receptors for the hormone on some cell lines.
"C-Squares," A New Spatial Indexing System and its Applicability to the Description of Oceanographic Datasets (2003)

A new method is described for representing, querying, displaying and exchanging dataset spatial extents at the metadata level. This method, entitled "c-squares" for Concise Spatial Query And Representation System, represents dataset spatial extents (footprints) as regular or irregular shapes built up from smaller component units (grid squares) coded according to a globally applicable system, and permits more reliable spatial queries than are presently enabled by the commonly used "bounding rectangles" method in metadata systems. The method is equally applicable to marine and terrestrial datasets but is particularly useful for marine data (which frequently have irregular, voyage-specific footprints), plus other dataset types not well represented by bounding rectangles.
T1 and T2 <i>ADAM33</i> single nucleotide polymorphisms and the risk of childhood asthma in a Saudi Arabian population: a pilot study (2012)

T1 A/G and T2 G/A ADAM33 polymorphisms, but not S1 or ST+4, were significantly associated with asthma development in Saudi children, like those reported for white and Hispanic populations in the United States.
Review. La Litterature de l'age baroque en France. Circe et le Paon. Rousset, Jean (1954)

Journal Article REVIEWS Get access La Littérature de l'âge baroque en France. Circé et le Paon. By JEAN ROUSSET. Paris: Corti. 1953. 312 pp. 1000 frs. W. G. MOORE W. G. MOORE OXFORD Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume VIII, Issue 3, July 1954, Pages 268–270, https://doi.org/10.1093/fs/VIII.3.268 Published: 01 July 1954
THE WATER-SOLUBLE POLYSACCHARIDES OF DERMATOPHYTES: IV. GALACTOMANNANS I FROM TRICHOPHYTON GRANULOSUM, TRICHOPHYTON INTERDIGITALE, MICROSPORUM QUINCKEANUM, TRICHOPHYTON RUBRUM, AND TRICHOPHYTON SCHÖNLEINII (1965)

A group of polysaccharides, called galactomannans I, were precipitated as their insoluble copper complexes from aqueous solutions of the crude polysaccharides obtained from each of the organisms designated in the title. The five galactomannans I were homogeneous under conditions of electrophoresis and ultracentrifugation and had high positive specific rotations. The major constituent monosaccharide was D-mannose; amounts of D-galactose ranged from nil for the polysaccharide from T. rubrum to 13% for that from T. schönleinii. Methylation and hydrolysis of the five galactomannans I yielded varying amounts of the following: 2,3,5,6-tetra-O-methyl-D-galactose (not present in the products from T. rubrum), 2,3,4,6-tetra-O-methyl-D-mannose, 2,3,4-tri-O-methyl-D-mannose, 2,4,6-tri-O-methyl-D-mannose, 3,4-di-O-methyl-D-mannose, and 3,5-di-O-methyl-D-mannose. Periodate oxidation results agreed with the methylation studies. The gross structural features of each galactomannan I appear to be the same, namely, a basic chain of 1 → 6 linked α-D-mannopyranose units for approximately every 22 of which there is a 1 → 3 linked α-D-mannopyranose residue. Branch points occur along the 1 → 6 linked chain at the C 2 positions of the D-mannopyranose units and once in every 45 units at the C 2 position of a 1 → 6 linked D-mannofuranose residue. The D-galactose in the polysaccharides is present exclusively as non-reducing terminal furanose units; non-reducing terminal units of D-mannopyranose are also present. The variations in the identities and relative amounts of the non-reducing terminal units were the only apparent differences in the gross structural features within this group of polysaccharides.
Analysis and Implementation of a Stereophonic Play Back System for Adjusting the “Sweet Spot” to the Listener’s Position (2009)

The papers at this Convention have been selected on the basis of a submitted abstract and extended precis that have been peer reviewed by at least two qualified anonymous reviewers. This convention paper has been reproduced from the author’s advance manuscript, without editing, corrections, or consideration by the Review Board. The AES takes no responsibility for the contents. Additional papers may be obtained by sending request and remittance to Audio
Replication of microneedle arrays using vacuum casting and hot embossing (2005)

The replication of silicon (Si) microneedle arrays via a soft silicone rubber mold into various polymers, namely SU-8, epoxy, cycloolefine copolymer (COC), and polycarbonate (PC) is reported. Vacuum casting and hot embossing are used to fabricate polymer wafers with 98 microneedle array dies with an individual size of 6/spl times/6 mm/sup 2/ each containing 841 microneedles. The same soft rubber mold can be used for both replication methods. Needles with heights of 75 /spl mu/m and 150 /spl mu/m, tip radii and edge radii below 2 /spl mu/m and 1 /spl mu/m, respectively, are excellently reproduced. The application of the needles in allergy testing is demonstrated.