gebhart/patrepeval huggingface dataset:
CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas (2016)

A hallmark of the diffuse large B-cell lymphoma (DLBCL) of the activated B-cell (ABC) type, a molecular subtype characterized by adverse outcome, is constitutive activation of the transcription factor nuclear factor-κB (NF-κB), which controls expression of genes promoting cellular survival and proliferation. Much less, however, is known about the role of the transcription factor activator protein-1 (AP-1) in ABC DLBCL. Here, we show that AP-1, like NF-κB, was controlled by constitutive activation of the B-cell receptor signaling component caspase recruitment domain-containing membrane-associated guanylate kinase 1 (CARMA1) and/or the Toll-like receptor signaling component myeloid differentiation primary response gene 88 (MyD88) in ABC DLBCL cell lines. In contrast to germinal center (GC) B-cell (GCB) DLBCL, ABC DLBCL cell lines expressed high levels of the AP-1 family members c-Jun, JunB, and JunD, which formed heterodimeric complexes with the AP-1 family members activating transcription factor (ATF) 2, ATF3, and ATF7. Inhibition of these complexes by a dominant-negative approach led to impaired growth of a majority of ABC DLBCL cell lines. Individual silencing of c-Jun, ATF2, or ATF3 decreased cellular survival and revealed c-Jun/ATF2-dependent control of ATF3 expression. As a consequence, ATF3 expression was much higher in ABC vs GCB DLBCL cell lines. Samples derived from DLBCL patients showed a clear trend toward high and nuclear ATF3 expression in nodal DLBCL of the non-GC or ABC subtype. These findings identify the activation of AP-1 complexes of the Jun/ATF-type as an important element controlling the growth of ABC DLBCL.
Movers and shakers: November 2015 (2015)

Your weekly round-up of the CAs and other business professionals moving into new roles in November.
Pincer “Hemilabile” Effect. PCN Platinum(II) Complexes with Different Amine “Arm Length” (2005)

The reactivity of the “long arm” PCN-type pincer ligand C6H4[CH2P(tBu)2](CH2)2N(CH3)2 (1), which forms complexes bearing a six-membered amine chelate and a five-membered phosphine chelate, was compared with that of the new “normal” PCN ligand C6H4[CH2P(tBu)2](CH2)N(CH2CH3)2 (2), which leads to formation of complexes bearing two five-membered chelates. The chloride complexes (PCN)PtCl (3, 4) and the unsaturated cationic complexes [(PCN)Pt]+X- (X = BF4, OTf) (5, 6, 7), based on both PCN ligands, were prepared and reacted with different reagents to give aqua, [(PCN-1)Pt(H2O)]+BF4- (10); hydroxo, (PCN-1)Pt(OH) (11); carbonyl [(PCN)Pt(CO)]+BF4- (8, 9); and hydride, (PCN-1)PtH (16) complexes. The structures of complexes 4, 6, 8, 10, 11, and 12 were determined by X-ray crystallography. When both carbonyl complexes were treated with hydrogen gas, the “long arm” PCN-1-based complex 8 led to formation of a trimeric cluster, [C6H6[CH2P(tBu)2](CH2)2N(CH3)2Pt(CO)]3 (12), while the “normal” PCN-based complex 9 remained unchanged under the same conditions. This observation clearly demonstrates the very significant effect of the amine arm length (five- vs six-membered chelate) on the hemilability of the ligand and the reactivity of the corresponding complexes.
Glucose absorption, hormonal release and hepatic metabolism after guar gum ingestion (1992)

Six non-anaesthetized Large White pigs (mean body weight 59 +/- 1.7 kg) were fitted with permanent catheters in the portal vein, the brachiocephalic artery and the right hepatic vein and with electromagnetic flow probes around the portal vein and the hepatic artery. The animals were provided a basal none-fibre diet (diet A) alone or together with 6% guar gum (diet B) or 15% purified cellulose (diet C). The diets were given for 1 week and according to a replicated 3 x 3 latin-square design. On the last day of each adaptation period test meals of 800 g were given prior to blood sampling. The sampling was continued for 8 h. Guar gum strongly reduced the glucose absorption as well as the insulin, gastric inhibitory polypeptide (GIP) and insulin-like growth factor-1 (IGF-1) production. However, the reduction in peripheral blood insulin levels caused by guar gum was not associated with a change in hepatic insulin extraction. IGF-1 appeared to be strongly produced by the gut. The liver had a net uptake of the peptide. Ingestion of guar gum increased the hepatic extraction coefficient of gut produced IGF-1. Guar gum ingestion also appeared to decrease pancreatic glucagon secretion. Cellulose at the level consumed had very little effect on the parameters considered. It is suggested that the modulation of intestinal mechanisms by guar gum was sufficient to mediate the latter internal metabolic effects.
Diels-Alder Reactions with Arylethenesulfonyl Fluorides (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiels-Alder Reactions with Arylethenesulfonyl FluoridesWilliam E. Truce and Fred D. HoergerCite this: J. Am. Chem. Soc. 1954, 76, 12, 3230–3232Publication Date (Print):June 1, 1954Publication History Published online1 May 2002Published inissue 1 June 1954https://pubs.acs.org/doi/10.1021/ja01641a046https://doi.org/10.1021/ja01641a046research-articleACS PublicationsRequest reuse permissionsArticle Views373Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DIGITAL CASH AND MONETARY FREEDOM (1995)

Much has been published recently about the awesome promises of electronic commerce and trade on the Internet if only a reliable, secure mechanism for value exchange could be developed. This paper describes the differences between mere encrypted credit card schemes and true digital cash, which presents a revolutionary opportunity to transform payments. The nine key elements of an electronic, digital cash are outlined and a tenth element is proposed which would embody digital cash with a non- political unit of value. It is this final element of true digital cash which represents monetary freedom — the freedom to establish and trade negotiable instruments. For the first time ever, each individual has the power to create a new value standard with an immediate worldwide audience. If all that digital cash permits is the ability to trade and store dollars, francs, and other governmental units of account, then we have not come very far. Even the major card associations, such as Visa and MasterCard, are limited to clearing and settling governmental units of account. For in an age of inflation and government ineptness, the value of what is being transacted and saved can be seriously devalued. Who wants a hard drive full of worthless “cash”? True, this can happen in a privately-managed digital cash system, but at least then it is determined by the market and individuals have choices between multiple providers. The section on key elements of a private digital cash system compares and contrasts true digital cash with paper cash as we know it today. Each of the following key elements will be defined and explored within the bounds of electronic commerce: — Secure (unable to alter or reproduce)
329. The acid-catalysed heterolysis of amides with alkyl-nitrogen fission (A AL) (1960)

R. N. Lacey, J. Chem. Soc., 1960, 1633 DOI: 10.1039/JR9600001633
Understanding Gas Phase Modifier Interactions in Rapid Analysis by Differential Mobility-Tandem Mass Spectrometry (2014)

A systematic study involving the use and optimization of gas-phase modifiers in quantitative differential mobility-mass spectrometry (DMS-MS) analysis is presented using nucleoside-adduct biomarkers of DNA damage as an important reference point for analysis in complex matrices. Commonly used polar protic and polar aprotic modifiers have been screened for use against two deoxyguanosine adducts of DNA: N-(deoxyguanosin-8-yl)-4-aminobiphenyl (dG-C8-4-ABP) and N-(deoxyguanosin-8-y1)-2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (dG-C8-PhIP). Particular attention was paid to compensation voltage (CoV) shifts, peak shapes, and product ion signal intensities while optimizing the DMS-MS conditions. The optimized parameters were then applied to rapid quantitation of the DNA adducts in calf thymus DNA. After a protein precipitation step, adduct levels corresponding to less than one modification in 10(6) normal DNA bases were detected using the DMS-MS platform. Based on DMS fundamentals and ab initio thermochemical results, we interpret the complexity of DMS modifier responses in terms of thermal activation and the development of solvent shells. At very high bulk gas temperature, modifier dipole moment may be the most important factor in cluster formation and cluster geometry, but at lower temperatures, multi-neutral clusters are important and less predictable. This work provides a useful protocol for targeted DNA adduct quantitation and a basis for future work on DMS modifier effects.
The Fabrication of High Precision Nozzles by the Anisotropic Etching of (100) Silicon (1978)

Arrays of nozzles of uniform size and spacing (≃0.3 mm) suitable for high quality and high speed ink‐jet printing have been fabricated by the anisotropic etching of holes through (100) Si wafers using conventional Si‐processing techniques. The etchant used is a mixture of pyrocatechol, ethylene diamine, and water. The nozzles are well‐defined truncated, square pyramidal cavities bounded by 4 convergent {111} planes. The square orifice, side , is given by , where is the side of the square base and the wafer thickness. Successful fabrication of these silicon microstructures requires the application of well‐controlled patterning and etching processes and the selection of a uniform, defect‐free, accurately oriented single crystal substrate.
Estimates of normal binding of a human recombinant alpha interferon to peripheral blood mononuclear cells from a study matching healthy subjects to subjects with insulin dependent diabetes. (1989)

This study compares the binding of a human recombinant alpha-interferon to peripheral blood mononuclear cells (PBMC) from patients with insulin dependent diabetes (IDDM) mellitus and control subjects. Diurnal and longer term of variation, feeding, fasting and haemoglobin glycosylation were examinated for their influence on interferon binding to PBMC. No gross differences in binding were demonstrated, in particular no effect of glucose levels was seen on the binding of interferon alpha-2 to PBMC.
Nanostructured conducting polymers for energy applications: towards a sustainable platform (2016)

Recently, there has been tremendous progress in the field of nanodimensional conducting polymers with the objective of tuning the intrinsic properties of the polymer and the potential to be efficient, biocompatible, inexpensive, and solution processable. Compared with bulk conducting polymers, conducting polymer nanostructures possess a high electrical conductivity, large surface area, short path length for ion transport and superior electrochemical activity which make them suitable for energy storage and conversion applications. The current status of polymer nanostructure fabrication and characterization is reviewed in detail. The present review includes syntheses, a deeper understanding of the principles underlying the electronic behavior of size and shape tunable polymer nanostructures, characterization tools and analysis of composites. Finally, a detailed discussion of their effectiveness and perspectives in energy storage and solar light harvesting is presented. In brief, a broad overview on the synthesis and possible applications of conducting polymer nanostructures in energy domains such as fuel cells, photocatalysis, supercapacitors and rechargeable batteries is described.
Managing abuse inquiries: methodology, organisation, process and politics (2001)

This paper offers a framework for managing abuse inquiries in social care. Drawing on experience of an inquiry into the physical abuse of people with learning disabilities and challenging behaviours in a residential service, it reviews the likely demands on inquiries, offers observations about stake‐holding and makes suggestions about inquiry management and reporting.
Evaluating HACMP/6000: a clustering solution for high availability distributed systems (2002)

The requirements for highly available computer systems have evolved over time. In a commercial environment end-users and consumers do not tolerate systems that are unavailable when needed. This paper describes and evaluates the High Availability Cluster Multi-Processing (HACMP/6000) product. HACMP/6000 is a clustering solution for high availability distributed systems. Our approach in showing the effectiveness of HACMP/6000 is both qualitative and quantitative. We use availability analysis as a means of our quantitative analysis. Availability analysis is undertaken using a state-of-the-art availability analysis tool-System Availability Estimator (SAVE). Results obtained from the analysis are used for comparison with a non-HACMP/6000 system.
PRODUCTION OF ETHERS OF GLYCEROL FROM CRUDE GLYCEROL - THE BY- PRODUCT OF BIODLESEL PRODUCTION (1998)

Part of the Biomaterials Commons This Article is brought to you for free and open access by the Chemical and Biomolecular Engineering Research and Publications at DigitalCommons@University of Nebraska- Lincoln. It has been accepted for inclusion in Papers in Biomaterials by an authorized administrator of
Antitumor effect of oral cancer vaccine with<i>Bifidobacterium</i>delivering WT1 protein to gut immune system is superior to WT1 peptide vaccine (2017)

Despite the revolutionary progress of immune checkpoint inhibitors (CPIs) for cancer immunotherapy, CPIs are effective only in a subset of patients. Combining CPIs and cancer vaccines to achieve better clinical outcomes is a reasonable approach since CPI enhances cancer vaccine-induced tumor-associated antigen (TAA) specific CTL. Among the various TAAs so far identified, WT1 protein is one of the most promising TAAs as a cancer vaccine target. Until now clinical trials of WT1 vaccine have demonstrated only modest clinical efficacy. These WT1 vaccines were based on peptides or dendritic cells (DCs), and there was no oral cancer vaccine. Recently, we developed a WT1 oral cancer vaccine using a recombinant Bifidobacterium displaying WT1 protein, which can efficiently deliver WT1 protein to the gut immune system, and we demonstrated that this oral cancer vaccine had a significant anti-tumor effect in a C1498-WT1 murine leukemia syngeneic tumor model. The WT1 protein displayed in this vaccine consists of about 70% of the WT1 amino acid sequence including multiple known CD4 and CD8 T-cell epitopes of WT1. In this commentary, we introduce our recent data indicating the superior anti-tumor effect of a WT1 oral cancer vaccine delivering WT1 protein to the gut immune system compared to a peptide vaccine.
Biomimetic Strategies for Sensing Biological Species (2013)

The starting point of modern biosensing was the application of actual biological species for recognition. Increasing understanding of the principles underlying such recognition (and biofunctionality in general), however, has triggered a dynamic field in chemistry and materials sciences that aims at joining the best of two worlds by combining concepts derived from nature with the processability of manmade materials, e.g., sensitivity and ruggedness. This review covers different biomimetic strategies leading to highly selective (bio)chemical sensors: the first section covers molecularly imprinted polymers (MIP) that attempt to generate a fully artificial, macromolecular mold of a species in order to detect it selectively. A different strategy comprises of devising polymer coatings to change the biocompatibility of surfaces that can also be used to immobilized natural receptors/ligands and thus stabilize them. Rationally speaking, this leads to self-assembled monolayers closely resembling cell membranes, sometimes also including bioreceptors. Finally, this review will highlight some approaches to generate artificial analogs of natural recognition materials and biomimetic approaches in nanotechnology. It mainly focuses on the literature published since 2005.
Synthesis of some 1H-1,3-benzodiazepines (1976)

The synthesis of 3,4-dihydro-1H-1,3-benzodiazepine-2,5-dione has been carried out, and the reactivity at positions 2, 5, and 7 investigated. Attempts to introduce a 4,5-double bond resulted in rearrangement to quinolines and indoles.
LABORATORY INVESTIGATION OF THE USE OF FOAMED ASPHALT FOR RECYCLED BITUMINOUS PAVEMENTS (1983)

Recent advances in foamed-asphalt technology have created new interest in the subject. A series of studies of foamed asphalt was conducted in Indiana. The results of one of these studies are described. The study had three objectives. The first was to determine the foaming characteristics of a selection of asphalts commonly used in construction in Indiana. Foaming characteristics in terms of expansion ratio and half-life were recorded. The second objective was to evaluate the performance of three of these asphalts as binders for a recycled bituminous paving mixture using (a) the gyratory and the Marshall compactive methods and (b) the Marshall stability testing procedure. The third objective was to evaluate the effect of curing time and moisture on the stability of a recycled mix. Three asphalts were chosen for the study based on their foaming characteristics. A foaming temperature of 325 deg F (160 deg C) and an added water content of 2 percent were selected as the best conditions for optimum foam volume and half-life. Excellent Marshall stability values were obtained with 0.5 and 1.0 percent foamed asphalt added to the recycled mixtures. Curing time had a marked effect on the lower additions of foamed asphalt. The effect of water decreases with increased amounts of foamed asphalt. (Author)
Crossbreeding East African Highland Bananas: Lessons Learnt Relevant to the Botany of the Crop After 21 Years of Genetic Enhancement (2019)

East African highland bananas (EAHB) were regarded as sterile. Their screening for female fertility with "Calcutta 4" as male parent revealed that 37 EAHB were fertile. This was the foundation for the establishment of the EAHB crossbreeding programs by the International Institute of Tropical Agriculture (IITA) and the National Agricultural Research Organization (NARO) in Uganda in the mid-1990s. The aim of this study was to assess the progress and efficiency of the EAHB breeding program at IITA, Sendusu in Uganda. Data on pollinations, seeds generated and germinated, plus hybrids selected between 1995 and 2015 were analyzed. Pollination success and seed germination percentages for different cross combinations were calculated. The month of pollination did not result in significantly different (<i>P</i> = 0.501) pollination success. <i>Musa acuminata</i> subsp. <i>malaccensis</i> accession 250 had the highest pollination success (66.8%), followed by the cultivar "Rose" (66.6%) among the diploid males. Twenty-five EAHB out of 41 studied for female fertility produced up to 305 seeds per pollinated bunch, and were therefore deemed fertile. The percentage of seed germination varied among crosses: 26% for 2<i>x</i> × 4<i>x</i>, 23% for 2<i>x</i> × 2<i>x</i>, 11% for 3<i>x</i> × 2<i>x</i>, and 7% for 4<i>x</i> × 2<i>x</i>. Twenty-seven NARITA hybrids (mostly secondary triploids ensuing from the 4<i>x</i> × 2<i>x</i>) were selected for further evaluation in the East African region. One so far -"NARITA 7"- was officially released to farmers in Uganda. Although pollination of EAHB can be conducted throughout the year, the seed set and germination is low. Thus, further research on pollination conditions and optimization of embryo culture protocols should be done to boost seed set and embryo germination, respectively. More research in floral biology and seed germination as well as other breeding strategies are required to increase the efficiency of the EAHB breeding program.
The Neutralization in Vitro of Avian Pneumoencephalitis Virus by Newcastle Disease Immune Serum (1944)

101MetricsTotal Downloads10Last 6 Months2Last 12 Months2Total Citations1Last 6 Months0Last 12 Months0View all metrics
The deltoid intramuscular injection site in the adult. Current practice among general practitioners and practice nurses. (2005)

A survey of 50 general practitioners and 50 practice nurses reviewed current practice in relation to intramuscular injections in the deltoid region of adults. The great majority of practitioners used the site for the intramuscular injection of vaccines and a wide range of other medications. The injection techniques employed by the two groups were similar. The great majority of respondents used either the middle one third or the upper half of the muscle. A significant minority of both groups used inappropriate depths of injection. Awareness of the structures which are at risk from injections in the region was poor in both groups. There is an urgent need to establish reliable protocols for the administration of safe, effective intramuscular injections at the deltoid site and to train practitioners in their use.
Carboranes. II. The Preparation of 1- and 1,2-Substituted Carboranes (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarboranes. II. The Preparation of 1- and 1,2-Substituted CarboranesMarvin M. Fein, Daniel Grafstein, John E. Paustian, Jack Bobinski, Bernard M. Lichstein, Nathan Mayes, Nelson N. Schwartz, and Murray S. CohenCite this: Inorg. Chem. 1963, 2, 6, 1115–1119Publication Date (Print):December 1, 1963Publication History Published online1 May 2002Published inissue 1 December 1963https://pubs.acs.org/doi/10.1021/ic50010a008https://doi.org/10.1021/ic50010a008research-articleACS PublicationsRequest reuse permissionsArticle Views1094Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts