gebhart/patrepeval huggingface dataset:
Round robin testing of thermal conductivity reference materials (1985)

Salinity stress severely affects plant growth and crop productivity. FCS-like zinc finger family genes (FLZ) play important roles in plant growth and stress responses. But most information of this family obtained was involved in sucrose signaling, limited function has been known in response to salinity stress. In this study, a novel FLZ gene TaFLZ2D has been isolated and characterized in response to salinity stress in wheat. TaFLZ2D was induced by both salinity stress and exogenous abscisic acid (ABA). Its transcript level was substantially higher in the salt resistant wheat cultivar SR3 than in its closely related but salt sensitive cultivar JN177. Transient expression in Nicotiana benthamiana leaf epidermal cells demonstrated TaFLZ2D was localized both in the cytoplasm membrane and nucleus. Constitutive expression of TaFLZ2D in Arabidopsis thaliana improved salinity stress tolerance and ABA sensitivity. Phenotype analysis under KCl and mannitol treatment demonstrated TaFLZ2D increased salinity stress tolerance mainly due to the superior ability to cope with ionic stress. TaFLZ2D over-expressing lines increased abscisic acid synthesis, peroxidase activity and reduced rate of water loss. Transcriptomic analysis demonstrated over-expression of TaFLZ2D regulated ABA-dependent and independent signaling pathway related genes expression and activated antioxidant related genes expression under normal condition and Ca<sup>2+</sup> signaling related genes expression under NaCl treatmemt. Taken together, TaFLZ2D is a positive regulator of salinity stress tolerance, which contributes to salinity stress mainly through superior ability for ionic stress tolerance and ROS detoxification.
Investigation of the effect of repetitive voltage surges on epoxy insulation (1992)

The aging of epoxy electrical insulation by unipolar, repetitive voltage surges has been investigated to determine whether such surges can precipitate premature failure of high-voltage motor windings and gas insulated switchgear spacers. A full factorial statistical test was devised and performed on 180 pure epoxy insulation specimens to examine the effect of voltage magnitude, polarity, and surge repetition rate on the life of unfilled epoxy specimens containing a needle-plane electrode geometry. All factors and interactions were determined to have a significant effect on the life, and life prediction equations were estimated. Increasing the voltage magnitude or repetition rate, decreased or increased the life, respectively. Aging was found to occur at as low a stress as 2 MV/cm. Gradual aging of the epoxy does occur under repetitive voltage surges. Based on a realistic number of surges with typical voltage amplitudes which can normally occur from vacuum switchgear during service, gradual deterioration of the epoxy turn insulation in motor stator windings is possible in some situations. Situations where surge aging may occur are identified.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Transposable element interactions in insects: crossmobilization of <i>hobo</i> and <i>Hermes</i> (1999)

There are four non-drosophilid insect gene vector systems available that have been constructed from the short inverted repeat-type transposable elements Minos, piggyBac, mariner and Hermes. These elements (with the possible exception of piggyBac) are members of transposable element families that appear to be widespread in nature. Because these transposable element families are large it is possible that an insect species targeted for transformation will contain related transposable elements. The data presented here begin to address directly the question of interaction between diverged but related members of transposable element families. We tested the ability of the hAT elements hobo and Hermes to interact and cause crossmobilization. Using plasmid-based and chromosome-based element mobility assays we found that the terminal sequences of hobo and Hermes were almost equally good substrates for hobo transposase. However, this ability to crossmobilize was not reciprocal. Hermes transposase was only rarely able to cause the excision of hobo elements from plasmids and was never observed from germline chromosomes. These results have important implications for transgenic insect studies in the future.
Segregation in sputtered Co-Cr films (1987)

The segregation growth process in sputtered Co-Cr films is investigated by examining the effect of substrate temperature on the segregated microstructure and magnetic properties. In sputtered Co-25at%Cr films, segregation occurs below 560°C, and both the saturation magnetization and the perpendicular anisotropy constant show a maximum around a substrate temperature of 300°C, where a specific microstructure, called a CP (chrysanthemum-like pattern) structure, is observed. The results suggest that the CP structure becomes observable in the highly segregated state and generates high perpendicular anisotropy. A new segregation growth model is derived from the results of the CP structure observations. Using this model, it is possible to explain the continuous transition of the magnetization mode between the continuous and the particulate modes.
State and parameter estimation for robotic manipulators using force measurements (1987)

The need to equip robotic systems with a high degree of dexterity and adaptability to a wide range of precise manipulation tusks has given rise to increasing interest in the utilization of various sensing modalities, including force and tactile sensing. In this paper a general framework is proposed for incorporating both a priori task geometry information and on-line observations, including force measurements, into an optimal estimation algorithm. The output of the algorithm is state and parameter estimates that serve to disambiguate the task geometry and can be used to dynamically adapt subsequent motions. The problem is formulated us a nonlinear constrained dynamical system, including Coulomb friction between the system and the constraints. The constraint surface is described with respect to some unknown parameters representing the geometric uncertainty. The noisy on-line state and force observations are expressed as functions of the state and surface parameters. The extended Kalman filter is then used to produce optimal estimates of the state and surface parameters.
Mobility management algorithms and applications for mobile sensor networks (2010)

Abstract Wireless sensor networks (WSNs) offer a convenient way to monitor physical environments. In the past, WSNs are all considered static to continuously collect information from the environment. Today, by introducing intentional mobility to WSNs, we can further improve the network capability on many aspects, such as automatic node deployment, flexible topology adjustment, and rapid event reaction. In this paper, we survey recent progress in mobile WSNs and compare works in this field in terms of their models and mobility management methodologies. The discussion includes three aspects. Firstly, we discuss mobility management of mobile sensors for the purposes of forming a better WSN, enhancing network coverage and connectivity, and relocating some sensors. Secondly, we introduce path‐planning methods for data ferries to relay data between isolated sensors and to extend a WSN's lifetime. Finally, we review some existing platforms and discuss several interesting applications of mobile WSNs. Copyright © 2010 John Wiley & Sons, Ltd.
A novel beamforming method for multiple peer-to-peer relay networks (2012)

One multi-antenna relay can support multiple peer-to-peer communications in AF (amplify-and-forward) manner. All sources transmit their signals to the relay in the first time slot. In the second time slot, the relay multiplies its received signal with an amplifying matrix, and broadcasts it to the destinations. We propose a novel method to specify the amplifying matrix in which we decompose the amplifying matrix into two parts. The first part is an MMSE (minimum mean square error) receiving matrix, and the second part is a beamforming matrix based on the maximization of VSLNR (virtual signal-to-leakage-plus-noise ratio). To apply our proposed algorithm, we first propose two simple power allocation methods: EPA (equal power allocation) and EGA (equal gain allocation), and then propose an optimization method using projection gradient algorithm. Numerical results show that our proposed algorithm outperforms the existing ZFBF (zero-forcing beamforming) algorithm and the optimal power allocation improves system performance significantly under asymmetric channel conditions.
An assessment of GafChromic film for measuring 50 kV and 100 kV percentage depth dose curves (2008)

Percentage depth dose (PDD) curves were obtained for 50 kV and 100 kV x-rays on a Gulmay Medical D3000 DXR unit. Different dosimetry systems were compared including a Scanditronix Wellhofer small volume cylindrical ion chamber, a Wellhofer photon PFD diode, a PTW soft x-ray parallel plate chamber (N23342) and two types of radiochromic film: GafChromic EBT and GafChromic MD55. The PDD curves were also compared to BEAMnrc Monte Carlo predictions. GafChromic film was found to be a valid choice of dosimeter for measuring percentage depth dose curves at 100 kV and 50 kV. All the dosimeters showed agreement with predictions at depths greater than 10 mm, while near the surface GafChromic film and PFD diodes give the best agreement to Monte Carlo values.
Copper-induced skeletal myopathy in rabbits. (1981)

Doses of 1.66 mg Cu/kg/day, as cupric acetate in aqueous solution, were injected intramuscularly into the lateral thigh muscles of rabbits. The rate of loss of Cu from the injection site was estimated from in vivo measurements of 64Cu injected on the 15th day. Biological half-life values were 1.0 h for the first component (accounting for 65.2% of the 64 Cu) and 14.6 h for the second component (34.8% of the 64Cu). For the control group, values were 0.8 h and 62.2%, 14.6 h and 37.8%. Grossly visible lesions of dermatitis were noted on the paws, i.e. at sites removed from the site of injection, in some rabbits injected with Cu acetate two days post injectionem (p.i.). Histologically detectable lesions of acute inflammation were seen as early as 24 hours p.i. at the injection site of rabbits which had been exposed to the Cu once. Multiple injections and longer time periods resulted in lesions of acute and chronic inflammation. Cu was detected by the use of rubeanic acid stain. Signs of muscle degeneration and regeneration were seen as early as three days p.i. in rabbits which had received two injections of Cu. Rabbits which had been killed six days p.i. after a single injection showed chronic inflammatory changes and newly formed myofibres. Rabbits which had been killed 37 days p.i. after 17 injections showed lesions of acute and chronic inflammation of muscle and surrounding connective tissue, as well as signs of muscle regeneration. The gangrene visible grossly was attributed to the ischaemia caused by conglomerations of Cu.
Transarterial Chemoembolization in Combination with a Molecular Targeted Agent: Lessons Learned from Negative Trials (Post-TACE, BRISK-TA, SPACE, ORIENTAL, and TACE-2) (2017)

The multikinase inhibitor sorafenib is the first oral molecular targeted agent with proven prognostic benefit in unresectable advanced hepatocellular carcinoma (HCC). However, as with other drugs, sorafenib has its limitations, and various clinical trials have been conducted to develop novel molecular targeted agents for use alone or in combination with existing locoregional therapies. Despite this, clinical trials of molecular targeted agents combined with transarterial chemoembolization (TACE) have not reported major treatment outcomes to date. In this review, we describe previous clinical trials of combination therapy with TACE and a molecular targeted agent in patients with unresectable HCC.
A proven embedded DRAM compiler for deep submicron logic processes and system-on-a-chip ASIC designs (2002)

This paper covers the motivations for and the advantages of using an embedded DRAM compiler technology within a standard deep submicron logic process for System-on-a-Chip (SoC). We also discuss the bit cell design and the memory architecture, as well as the automation software and methodology used in the construction of the DRAM compiler. Silicon results from the test chips are favorable. This approach makes economical and time-to-market sense, therefore it can be a viable high-performance and area-efficient option in the embedded DRAM technology.
TORC1 and class I HDAC inhibitors synergize to suppress mature B cell neoplasms (2013)

Enhanced proliferative signaling and loss of cell cycle regulation are essential for cancer progression. Increased mitogenic signaling through activation of the mTOR pathway, coupled with deregulation of the Cyclin D/retinoblastoma (Rb) pathway is a common feature of lymphoid malignancies, including plasmacytoma (PCT), multiple myeloma (MM), Burkitt's lymphoma (BL), and mantle cell lymphoma (MCL). Here we evaluate the synergy of pharmacologically affecting both of these critical pathways using the mTOR inhibitor sirolimus and the histone deacetylase inhibitor entinostat. A dose-matrix screening approach found this combination to be highly active and synergistic in a panel of genetically diverse human MM cell lines. Synergy and activity was observed in mouse PCT and human BL and MCL cell lines tested in vitro, as well as in freshly isolated primary MM patient samples tested ex vivo. This combination had minimal effects on healthy donor cells and retained activity when tested in a co-culture system simulating the protective interaction of cancer cells with the tumor microenvironment. Combining sirolimus with entinostat enhanced cell cycle arrest and apoptosis. At the molecular level, entinostat increased the expression of cell cycle negative regulators including CDKN1A (p21) and CDKN2A (p16), while the combination decreased critical growth and survival effectors including Cyclin D, BCL-XL, BIRC5, and activated MAPK.
Cooperative interaction of multiple DNA elements in the human interferon-beta promoter (1987)

Analysis of promoter mutants and hybrids in permanently transformed murine L cells reveals several regulatory DNA sequence elements in the 5' flanking region of the human interferon-beta gene, which together constitute the inducible promoter. The elements consist almost exclusively of purine runs in the region -111 to -1. Deletion of single elements reduces the expression capacity drastically, whereas duplication leads to a synergism of inducible expression. These elements act together in a cooperative way to achieve high inducibility. Natural and mutant promoter fragments containing these elements impose inducibility on a heterologous promoter. However, typical enhancer activity in this system is not observed.
Molecular-orbital theory of monatomic and diatomic substitutional defects as shallow<i>n</i>-type dopants in diamond (1996)

A survey of potential shallow n-type donors in diamond was performed using the atom superposition and electron delocalization molecular-orbital method. Electronic structure and defect stabilities were estimated for N, P, O, S, F, and Cl in substitutional monovacancy sites; I, Xe, and the atom pairs BO, BS, NO, NS, and BeCl were studied on substitutional divacancy sites. The calculations indicate that the BS, NS, and BeCl pairs and I in divacancy sites may provide shallow donor levels, and may be more stable than P in a monovacancy site. \textcopyright{} 1996 The American Physical Society.
The miR-10 microRNA precursor family (2011)

The miR-10 microRNA precursor family encodes a group of short non-coding RNAs involved in gene regulation. The miR-10 family is highly conserved and has sparked the interest of many research groups because of the genomic localization in the vicinity of, coexpression with and regulation of the Hox gene developmental regulators. Here, we review the current knowledge of the evolution, physiological function and involvement in cancer of this family of microRNAs.
Equilibrium Structures for Butadiene and Ethylene:  Compelling Evidence for Π-Electron Delocalization in Butadiene (2006)

Equilibrium structures have been determined for s-trans-1,3-butadiene and ethylene after adjusting the rotational constants obtained from rotational spectroscopy by vibration-rotation constants calculated from the results of quantum chemical calculations. For butadiene, the formal C=C bond length is 1.338 A, and the formal C-C bond length is 1.454 A. For ethylene, the C=C bond length is 1.3305 A. These values appear to be good to 0.001 A. It is shown for the first time that pi-electron delocalization has the structural consequences of increasing the length of the formal double bond by 0.007 A and decreasing the length of the formal single bond by 0.016 A. Comparisons are made with structures computed with several quantum chemical models. The MP2/cc-pVTZ results agree best with the new re structure.
High-Pressure Injection Pumps with Electronic Control for Heavy-Duty Diesel Engines (1985)

<div class="htmlview paragraph">Within the Robert Bosch Diesel Injection Pump Program, the MW and P pumps have a fundamental significance concerning medium-duty and heavy- duty engines.</div> <div class="htmlview paragraph">These engines have developed considerably in the last years with regard to combustion efficiency and emission reduction. In order to reach these new targets, specific developments of the pump were necessary to realize injection pressure of 900 bar and 1200 bar for the MW and P pumps, respectively.</div> <div class="htmlview paragraph">A further development emphasis of the past years was the development of a robust electronic governor concept to take advantage of this new technology.</div> <div class="htmlview paragraph">The topics of the paper are: <ul class="list disc"> <li class="list-item"><div class="htmlview paragraph">Further development of the pump drivetrain and housing to cope with the difficulties inherent in producing 1000 bar.</div></li> <li class="list-item"><div class="htmlview paragraph">Development of constant-pressure valves.</div></li> <li class="list-item"><div class="htmlview paragraph">Preparation of the electronic governor concept for commercial vehicles.</div></li> <li class="list-item"><div class="htmlview paragraph">Development results of the electro-magnetic and electro-hydraulic actuators.</div></li> </ul> </div>
Prediction by Supervised Principal Components (2006)

In regression problems where the number of predictors greatly exceeds the number of observations, conventional regression techniques may produce unsatisfactory results. We describe a technique called supervised principal components that can be applied to this type of problem. Supervised principal components is similar to conventional principal components analysis except that it uses a subset of the predictors selected based on their association with the outcome. Supervised principal components can be applied to regression and generalized regression problems, such as survival analysis. It compares favorably to other techniques for this type of problem, and can also account for the effects of other covariates and help identify which predictor variables are most important. We also provide asymptotic consistency results to help support our empirical findings. These methods could become important tools for DNA microarray data, where they may be used to more accurately diagnose and treat cancer.
Zeolitic Membranes: Synthesis, Properties, and Prospects (1997)

Abstract This article is intended to describe recent progress in the synthesis of zeolitic membranes and their permeation properties. While hydrothermal synthesis has been widely employed for zeolitic-membrane synthesis, the development of a new technique for zeolite synthesis, vapor-phase transport (VPT), has enabled us to prepare pinhole-free, zeolite-porous support composite membranes. This article consists of three sections that describe: a survey of the hydrothermal synthesis of zeolitic membranes, our synthesis results and the formation mechanism of zeolitic membranes by the VPT method as well as some permeation results to show the prospects of zeolitic membranes.
Vitrification of human spermatozoa without cryoprotectants. (2002)

The aim of our study was to investigate the effects of vitrification (cooling rate approximately 10000(C/min) without cryoprotectants on swim-up prepared human spermatozoa in comparison to standard conventional freezing with cryoprotectants. Motility, morphology, rate of viability and acrosome reaction of spermatozoa were evaluated. The described method of cryopreservation of human spermatozoa by direct plunging into liquid nitrogen slush without cryoprotectants was effective and could be recommended for routine IVF.
Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant (2002)

We recently reported that parenteral injection of malaria palmitoyl-tailed peptides without adjuvant efficiently induces B, Th and CTL responses. We now show that intranasal (IN) or sub-lingual (SL) delivery of such lipopeptides induces strong systemic immune responses, as demonstrated by specific Th cell responses from the spleen as well as inguinal lymph nodes, and by the production ofhigh levels of serum antibodies. Overall, both types of responses were significantly higher than in parallel experiments in which the same lipopeptides were delivered by the subcutaneous (s.c.) route. Moreover, the mucosal route resulted in the preferential induction of IFN-gamma producing T cells and of IgG2a antibody production, as compared to the dominant IL-4 and IgG1 responses obtained by the s.c. route, thus bringing a distinct advantage in the field of many infectious diseases and allergy. Possibly related to this Th1 response, we found that dendritic cells, the principal immune-competent cells to encounter antigens within mucosal membranes, take up lipopeptide antigens more efficiently than macrophages. Mucosal immunization by lipidated peptides appears therefore as a novel, noninvasive vaccine approach that does not require the use of extraneous adjuvant and which, besides cost-effectiveness, has attractive practical and immunological features.
Capillary Flow Impairment and Functional Capillary Density (1995)

Functional capillary density is variable in both normal and diseased tissue. When this parameter is defined as the number of capillaries that possess red blood cell transit, changes in functional capillary density reflect mechanisms that modulate the entrance of red blood cells into the capillaries. These mechanisms have anatomical origin, whereby the capillary diameter changes, and may also be hydrodynamic, when flow conditions prevent red blood cells from entering a capillary branch. An intrinsic feature of both processes is that capillaries undergo lumenal changes. Capillary lumen is determined by a composite of mechanical and cellular factors, where intravascular pressure is one of the principal determinants affecting diameter as a consequence of the elastic properties of the capillary/tissue system. The hydration of the surrounding tissue and the cellular volume regulation of the endothelium are additional factors. There is increasing evidence that capillaries possess contractility and that this phenomenon has spontaneous components. Consequently, functional capillary density is the resultant of both passive and active processes present at the level of individual vessels.