gebhart/patrepeval huggingface dataset:
Potential vaccine antigens of the asexual blood-stages of Plasmodium falciparum. (1985)

We have constructed a cDNA clone library that contains many natural immunogens of the asexual blood-stages of Plasmodium falciparum. The corresponding parasite antigens have been identified with antisera raised against the antigens expressed in Escherichia coli or with monospecific human antibodies purified on adsorbents prepared from various clones. Sequencing studies on the clones have revealed that many malaria antigens contain extensive sequence repeats. These repeats encode antigenic epitopes that in several proteins have been shown to be immunodominant. One candidate vaccine molecule, the Ring-infected Erythrocyte Surface Antigen (RESA), which is transferred from inside merozoites to the erythrocyte surface at about the time of merozoite invasion, contains two blocks of antigenically cross-reactive repeats. The structures of other antigens containing extensive repeats are described and their possible significance to the host-parasite relationship is discussed.
Transforming Agriculture through Pervasive Wireless Sensor Networks (2007)

A large-scale, outdoor pervasive computing system uses static and animal-borne nodes to measure the state of a complex system comprising climate, soil, pasture, and animals. Agriculture faces many challenges, such as climate change, water shortages, labor shortages due to an aging urbanized population, and increased societal concern about issues such as animal welfare, food safety, and environmental impact. Humanity depends on agriculture and water for survival, so optimal, profitable, and sustainable use of our land and water resources is critical.
Cloud Computing System Based on Trusted Computing Platform (2010)

Cloud computing provides people a way to share large mount of distributed resources belonging to different organizations. That is a good way to share many kinds of distributed resources, but it also makes security problems more complicate and more important for users than before. In this paper, we analyze some security requirements in cloud computing environment. Since the security problems both in software and hardware, we provided a method to build a trusted computing environment for cloud computing by integrating the trusted computing platform (TCP) into cloud computing system. We propose a new prototype system, in which cloud computing system is combined with Trusted Platform Support Service (TSS) and TSS is based on Trusted Platform Module (TPM). In this design, better effect can be obtained in authentication, role based access and data protection in cloud computing environment.
Quantifying the Heat-Related Hazard for Children in Motor Vehicles (2010)

Thirty-seven children on average die each year in the United States from vehicle-related hyperthermia. In many cases, the parent or caregiver intentionally left the child unattended in the car, unaware of how quickly temperatures may reach deadly levels. To better quantify how quickly temperatures may increase within a car, maximum rates of temperature change were computed from data collected on 14 clear days in Athens, Georgia. Also, a human thermal exchange model was used in a case study to investigate the influence of different meteorological factors on the heat stress of a child in a hot vehicle. Results indicate that a car may heat up by approximately 4°C in 5 min, 7°C in 10 min, 16°C in 30 min, and 26°C in 60 min. Within the vehicle, the dominant energy transfers toward the child are via longwave radiation and conduction from the hot interior surfaces of the car. Modeling simulations show that sun exposure and high-humidity conditions further increase the heat stress on the child but that a negative feedback involving evaporated perspiration reduces the influence of variations in humidity on net heat storage. Last, a table of vehicle temperature changes is included that may help public officials and the media communicate the dangers of vehicle-related hyperthermia in children.
Comprehensive Clinical Evaluation of Femoroacetabular Impingement: Part 2, Plain Radiography (2017)

The use of hip arthroscopy to treat various forms of hip pathology continues to grow. As part of a standard evaluation for eligibility for hip arthroscopy, we routinely obtain standard radiographs to assess the hip joint. These include orthogonal projections of the acetabulum and proximal femur, which can be obtained with a standing false profile, supine anteroposterior pelvis, and a lateral view of the proximal femur (either Dunn 45° or 90°, frog-leg lateral, or cross-table lateral). A comprehensive analysis of the radiographs is of utmost importance in order to indicate a patient for hip arthroscopy, for preoperative planning, and to determine prognosis. The purpose of this Technical Note is to provide a comprehensive guide of how our group performs qualitative and quantitative analysis of hip radiographs in a potential candidate for hip arthroscopy.
TcO(PnAO-1-(2-nitroimidazole)) [BMS-181321], a new technetium-containing nitroimidazole complex for imaging hypoxia: synthesis, characterization, and xanthine oxidase-catalyzed reduction (1994)

A technetium(V)oxo nitroimidazole complex that shows promise for imaging regional hypoxia in vivo, [BMS-181321, TcO(PnAO-1-(2-nitroimidazole))] (1) was prepared from 3,3,9,9-tetramethyl-1-(2-nitro-1H-imidazol-1-yl)-4,8-diazaundecane -2,10-dione dioxime, a 2-nitroimidazole-containing derivative of propyleneamine oxime (PnAO). The 99Tc complex [99Tc]Oxo[[3,3,9,9-tetramethyl-1-(2-nitro-1H-imidazol-1-yl)-4,8- diazaundecane-2,10-dione dioximato]-(3-)-N,N',N'',N''']technetium (V) was synthesized both from pertechnetate and [TcO(Eg)2]- (Eg = ethylene glycol). A new synthetic route to TcO(PnAO) (2) is also described. 99TcO(PnAO-1-(2-nitroimidazole)) was characterized by 1H NMR, IR, and UV/vis spectroscopy, HPLC, FAB mass spectrometry, and X-ray crystallography. Electrochemistry of 1 reveals that the nitro redox chemistry found in the ligand is maintained upon coordination to technetium but shifts to a slightly more positive potential. Using chiral HPLC (Chiracel OD), 99mTc (1) was resolved into its two enantiomers. However, the two isomers were found to racemize quickly (t1/2 < 2 min) in the presence of water. Localization of 1 is believed to be mediated by enzymatically catalyzed reduction of the nitroimidazole group, so the in vitro reaction of 99Tc(1) with the nitroreductase enzyme xanthine oxidase (XOD) was studied. XOD catalyzed the quantitative reduction of the nitroimidazole group on the molecule under anaerobic conditions in the presence of hypoxanthine. No reaction was noted using a non-nitro-containing complex (2). The rate of reduction of the Tc-nitroimidazole complex (1.5 +/- 0.16 nmol/min per unit XOD) was faster than that observed previously for the nitroimidazole BATOs (BATO = boronic acid adduct of technetium dioxime) and was about two-thirds that of fluoromisonidazole, a compound that has proven useful for imaging hypoxia in humans when labeled with 18F. These data suggest that BMS-181321 (1) has the potential to be recognized by nitroreductase enzymes in vivo, thus satisfying one of the criteria required for this potential hypoxia imaging agent.
MinCD Proteins Control the Septation Process during Sporulation of <i>Bacillus subtilis</i> (1998)

Mutation of the divIVB locus in Bacillus subtilis causes misplacement of the septum during cell division and allows the formation of anucleate minicells. The divIVB locus contains five open reading frames (ORFs). The last two ORFs (minCD) are homologous to minC and minD of Escherichia coli but a minE homolog is lacking in B. subtilis. There is some similarity between minicell formation and the asymmetric septation that normally occurs during sporulation in terms of polar septum localization. However, it has been proposed that MinCD has no essential role in sporulation septum formation. We have used electron microscopic studies to show septation events during sporulation in some minD strains. We have observed an unusually thin septum at the midcell position in minD and also in minD spoIIE71 mutant cells. Fluorescence microscopy also localized a SpoIIE-green fluorescent protein fusion protein at the midcell site in minD cells. We propose that the MinCD complex plays an important role in asymmetric septum formation during sporulation of B. subtilis cells.
Looking ahead makes query plans robust (2017)

Query optimizers and query execution engines cooperate to deliver high performance on complex analytic queries. Typically, the optimizer searches through the plan space and sends a selected plan to the execution engine. However, optimizers may at times miss the optimal plan, with sometimes disastrous impact on performance. In this paper, we develop the notion of robustness of a query evaluation strategy with respect to a space of query plans. We also propose a novel query execution strategy called Lookahead Information Passing (LIP) that is robust with respect to the space of (fully pipeline-able) left-deep query plan trees for in-memory star schema data warehouses. LIP ensures that execution times for the best and the worst case plans are far closer than without LIP. In fact, under certain assumptions of independent and uniform distributions, any plan in that space is theoretically guaranteed to execute in near-optimal time. LIP ensures that the execution time for every plan in the space is nearly-optimal. In this paper, we also evaluate these claims using workloads that include skew and correlation. With LIP we make an initial foray into a novel way of thinking about robustness from the perspective of query evaluation, where we develop strategies (like LIP) that collapse plan sub-spaces in the overall global plan space.
It Is Time to Address Airborne Transmission of Coronavirus Disease 2019 (COVID-19) (2020)

We appeal to the medical community and to the relevant national and international bodies to recognize the potential for airborne spread of coronavirus disease 2019 (COVID-19). There is significant potential for inhalation exposure to viruses in microscopic respiratory droplets (microdroplets) at short to medium distances (up to several meters, or room scale), and we are advocating for the use of preventive measures to mitigate this route of airborne transmission...
Isobenzofuran-aryne cycloadducts: formation and regioselective conversion to anthrones and substituted polycyclic aromatics (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsobenzofuran-aryne cycloadducts: formation and regioselective conversion to anthrones and substituted polycyclic aromaticsJill Netka, Stephen L. Crump, and Bruce RickbornCite this: J. Org. Chem. 1986, 51, 8, 1189–1199Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/jo00358a007https://doi.org/10.1021/jo00358a007research-articleACS PublicationsRequest reuse permissionsArticle Views1666Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle. (1996)

Defects of glucose transport and phosphorylation may underlie insulin resistance in obesity and non-insulin-dependent diabetes mellitus (NIDDM). To test this hypothesis, dynamic imaging of 18F-2-deoxy-glucose uptake into midthigh muscle was performed using positron emission tomography during basal and insulin-stimulated conditions (40 mU/m2 per min), in eight lean nondiabetic, eight obese nondiabetic, and eight obese subjects with NIDDM. In additional studies, vastus lateralis muscle was obtained by percutaneous biopsy during basal and insulin-stimulated conditions for assay of hexokinase and citrate synthase, and for immunohistochemical labeling of Glut 4. Quantitative confocal laser scanning microscopy was used to ascertain Glut 4 at the sarcolemma as an index of insulin-regulated translocation. In lean individuals, insulin stimulated a 10-fold increase of 2-deoxy-2[18F]fluoro-D-glucose (FDG) clearance into muscle and significant increases in the rate constants for inward transport and phosphorylation of FDG. In obese individuals, the rate constant for inward transport of glucose was not increased by insulin infusion and did not differ from values in NIDDM. Insulin stimulation of the rate constant for glucose phosphorylation was similar in obese and lean subjects but reduced in NIDDM. Insulin increased by nearly twofold the number and area of sites labeling for Glut 4 at the sarcolemma in lean volunteers, but in obese and NIDDM subjects translocation of Glut 4 was attenuated. Activities of skeletal muscle HK I and II were similar in lean, obese and NIDDM subjects. These in vivo and ex vivo assessments indicate that impaired glucose transport plays a key role in insulin resistance of NIDDM and obesity and that an additional impairment of glucose phosphorylation is evident in the insulin resistance of NIDDM.
Plasminogen activator synthesis accompanying chemical carcinogen‐induced <i>in vitro</i> transformation of syrian hamster and guinea‐pig fetal cells (1980)

The production of the extracellular protease, plasminogen activator, in relationship to growth in semi-solid medium and tumorigenicity has been studied in Syrian hamster embryo and strain 2 guinea-pig embryo cell culture models of chemical carcinogenesis. Whereas normal hamster and guinea-pig embryo cells had negligible levels of plasminogen activator, neoplastically transformed cells derived from cultures exposed to chemical carcinogens had high levels of plasminogen activator and grew as progressively enlarging colonies in soft agar. The development of plasminogen activator secretion in relation to neoplastic transformation was further studied in the guinea-pig cells where the latent period between carcinogen exposure and neoplastic transformation ranged from 4 months to more than one year. The production of plasminogen activator in this system also exhibited a long latent period, and acquisition of extracellular plasminogen activator correlated temporally with growth in agar and tumorigenicity. Plasminogen activator and growth in semi-solid agar in concert are useful markers for identification of neoplastic cells transformed in culture following exposure to a chemical carcinogen.
Widespread occurrence of<i>N</i><sup>6</sup>-methyladenosine in bacterial mRNA (2015)

N(6)-methyladenosine (m(6)A) is the most abundant internal modification in eukaryotic messenger RNA (mRNA). Recent discoveries of demethylases and specific binding proteins of m(6)A as well as m(6)A methylomes obtained in mammals, yeast and plants have revealed regulatory functions of this RNA modification. Although m(6)A is present in the ribosomal RNA of bacteria, its occurrence in mRNA still remains elusive. Here, we have employed ultra-high pressure liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC-QQQ-MS/MS) to calculate the m(6)A/A ratio in mRNA from a wide range of bacterial species, which demonstrates that m(6)A is an abundant mRNA modification in tested bacteria. Subsequent transcriptome-wide m(6)A profiling in Escherichia coli and Pseudomonas aeruginosa revealed a conserved m(6)A pattern that is distinct from those in eukaryotes. Most m(6)A peaks are located inside open reading frames and carry a unique consensus motif of GCCAU. Functional enrichment analysis of bacterial m(6)A peaks indicates that the majority of m(6)A-modified genes are associated with respiration, amino acids metabolism, stress response and small RNAs, suggesting potential functional roles of m(6)A in these pathways.
2,5-Dihydroxy-p-benzenediacetic Acid and Related Compounds from p-Benzoquinone<sup>1</sup> (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2,5-Dihydroxy-p-benzenediacetic Acid and Related Compounds from p-Benzoquinone1J. H. Wood, C. S. Colburn Jr., Lucile Cox, and H. C. GarlandCite this: J. Am. Chem. Soc. 1944, 66, 9, 1540–1542Publication Date (Print):September 1, 1944Publication History Published online1 May 2002Published inissue 1 September 1944https://pubs.acs.org/doi/10.1021/ja01237a038https://doi.org/10.1021/ja01237a038research-articleACS PublicationsRequest reuse permissionsArticle Views586Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dramatic tuning of ligand donor properties in (Ttz)CuCO through remote binding of H+ (Ttz = hydrotris(triazolyl)borate) (2013)

Complexes with bulky hydrotris(triazolyl)borate (Ttz) ligands, TtzCuCO, were used to probe how acids change the donor properties of Ttz ligands. (Ttz(tBu,Me))CuCO shows four distinct protonation states and a gradual increase in the CO stretch. The increased electrophilic nature of the Cu center upon protonation leads to enhanced C-H activation catalysis.
Supporting State-Wide Immunisation Tracking Using Multi-Paradigm Workflow Technology (1996)

The rapidly evolving managed healthcare industry requires efficient coordination of human and automated tasks as well as information-flow across multiple enterprises. One of the most critical applications in managed care is state-wide immunization tracking, which if supported by appropriate workflow technology can achieve substantial near term impact. In this paper, we discuss a comprehensive and real-world application to support child immunization tracking for the state of Connecticut in close collaboration with CHREFl. The application system uses UGA-LSDIS’s2 multi-paradigm transactional workflow management system METEOR:!. It utilizes the World Wide Web either exclusively, or in conjunction with CORBA-based infrastructures. Permission to copy without fee afl or part of lhi8 material is granted provided that the copie8 are not made or distributed for direct commercial advantage, the VLDB copyright notice and the title of the publication and its date appear, and notice i8 given that copying is by permission of the Very Large Data Base Endowment. To copy otherwise, or to republish, require8 a fee and/or special permission from the Endowment. Proceedings of the 22nd VLDB Conference Mumbai(Bombay), India, 1996 ‘Connecticut Healthcare Research and Education Foundation .‘Large Scale Distributed Information Systems Lab., The University of Georgia
Low-noise 62 W CW intracavity-doubled TEM_00 Nd:YVO_4 green laser pumped at 888 nm (2007)

We present a CW intracavity frequency-doubled TEM(00) Nd:YVO(4) laser oscillator pumped at 888 nm, producing 62W of green light at 532 nm with M(2)=1.05 and RMS noise of 0.05%, thanks to the simultaneous oscillation of a large number of longitudinal modes. A diode-to-green optical efficiency of 29% is achieved by the use of a noncritically phase-matched lithium triborate crystal inserted in a periodic resonator containing two Nd:YVO(4) crystals pumped with a total of 211W at 888 nm.
Multi-sample micro-slit rheometry (2008)

We have developed a multi-sample micro-slit rheometer (MMR) which is capable of measurements over a broad range of temperatures, viscosities and shear rates. The instrument is mechanically simple as the flow is generated by external gas pressure and the shear rate is measured through optical tracking of the flow front. In the current implementation, the required volume of each sample is approximately 20μL and we measure four samples simultaneously. We demonstrate the performance of the MMR by measurement of the flow curves (viscosity versus shear rate) of three representative polymers: A polydimethylsiloxane melt, a polyisobutylene solution, and a polystyrene melt. We adapt standard data correction methods to account for shear-thinning and entry/flow-front effects. We report a high level of accuracy and precision. This instrument will be particularly useful in cases of multiple samples, limited material quantity, and when optical access is useful.
Complete wavefront reconstruction using sequential intensity measurements of a volume speckle field (2006)

The recording of the volume speckle field from an object at different planes combined with the wave propagation equation allows the reconstruction of the wavefront phase and amplitude without requiring a reference wave. The main advantage of this single-beam multiple-intensity reconstruction (SBMIR) technique is the simple experimental setup because no reference wave is required as in the case of holography. The phase retrieval technique is applied to the investigation of diffusely transmitting and reflecting objects. The effects of different parameters on the quality of reconstructions are investigated by simulation and experiment. Significant enhancements of the reconstructions are observed when the number of intensity measurements is 15 or more and the sequential measurement distance is 0.5 mm or larger. Performing two iterations during the reconstruction process using the calculated phase also leads to better reconstruction. The results from computer simulations confirm the experiments. Analysis of transverse and longitudinal intensity distributions of a volume speckle field for the SBMIR technique is presented. Enhancing the resolution method by shifting the camera a distance of a half-pixel in the lateral direction improves the sampling of speckle patterns and leads to better quality reconstructions. This allows the possibility of recording wave fields from larger test objects.