gebhart/patrepeval huggingface dataset:
Fast approximate calculation of multiply scattered lidar returns (2006)

An efficient method is described for the approximate calculation of the intensity of multiply scattered lidar returns. It divides the outgoing photons into three populations, representing those that have experienced zero, one, and more than one forward-scattering event. Each population is parameterized at each range gate by its total energy, its spatial variance, the variance of photon direction, and the covariance of photon direction and position. The result is that for an N-point profile the calculation is O(N2) efficient and implicitly includes up to N-order scattering, making it ideal for use in iterative retrieval algorithms for which speed is crucial. In contrast, models that explicitly consider each scattering order separately are at best O(Nm/m!) efficient for m-order scattering and often cannot be performed to more than the third or fourth order in retrieval algorithms. For typical cloud profiles and a wide range of lidar fields of view, the new algorithm is as accurate as an explicit calculation truncated at the fifth or sixth order but faster by several orders of magnitude.
Performance of neighbor discovery algorithms in mobile ad hoc self-configuring networks with directional antennas (2005)

One of the key performance measures for a neighbor discovery algorithm in military applications with directional antennas is how long it takes to discover the neighbors given that nodes do not have priori knowledge about where their neighbors are. One general impression in neighbor discovery is that algorithms based on all directional (directional transmission and directional receive) takes longer time to discover all neighbors than those algorithms partially or entirely based on omni-directional antennas. In this paper, we prove that this may not be the case. We first describe a generic random neighbor discovery algorithm (GRA), which uses omni-directional antennas for reception. Then we derive analytical expressions for the average number of slots required to discover all (or any one of) the neighbors for GRA and for an all-directional, scan based algorithm (omni-directional antennas are not used at all). Analytic and simulation results are presented to compare the two algorithms in terms of the expected number of slots required to discover any one or all of the neighbors. Based on the numerical results, we conclude that scan-based all-directional algorithm gives better performance than the algorithm which uses omni-antennas. If designed properly, all-directional neighbor discovery algorithms can discover neighbors in less time than those algorithms that use omnidirectional antennas. The advantages and disadvantages of each algorithm are discussed as well.
A Precision Measurement of the Neutrino Mixing Angle theta_13 using Reactor Antineutrinos at Daya Bay (2007)

A reactor-neutrino experiment, Daya Bay, has been proposed to determine the least-known neutrino mixing angle theta_13 using electron antineutrinos produced at the Daya Bay nuclear power complex in China. Daya Bay is an international collaboration with institutions from China, the United States, the Czech Republic, Hong Kong, Russia, and Taiwan. The experiment will use eight identical detectors deployed at three different locations optimized for monitoring the antineutrino rates from the six reactors and for detecting any rate deficit and spectral distortion near the first oscillation maximum. The overburden of the under ground experimental halls, connected with tunnels, ranges from about 250 to 900 meters-water-equivalent so that the cosmogenic background is small compared to the number of observed antineutrino events. Civil construction of tunnels and experimental facilities is planned to start in 2007, with detector construction beginning in 2008. The experiment will begin collecting data in 2010. By comparing the detected signals at the three locations, with three years of data, a sensitivity in sin**2(2theta_13) of better than 0.01 is expected.
Observation of quantum confinement by strain gradients (1991)

We have created one-dimensional quantum wells (quantum wires) by laterally straining a GaAs quantum well with patterned carbon stressors 180 nm in width. We find four well-resolved one-dimensional subbands in the excitation spectra, whose constant spacing of 2.4 meV confirms quantitatively that there is quantum confinement in the parabolic well predicted by continuum elasticity theory. The lateral width of the electron ground state is 35 nm.
Ethanol: Software defined networking for 802.11 Wireless Networks (2015)

Wireless Networks have become ubiquitous and dense to support the growing demand from mobile users. To improve the performance of these networks, new approaches are required, such as context and service aware control algorithms, which are not possible on today's closed proprietary WLAN controllers. In this work, we propose Ethanol, a software-defined networking architecture for 802.11 dense WLANs. This paper describes the benefits of programmable APs, and proposes Ethanol, an architecture for network-wide control of QoS, user mobility, AP virtualization, and security on 802.11 APs. The proposal is evaluated on a prototype using off-the-shelf APs over three use cases.
A Note on the Optimal Assignment of Facilities to Locations by Branch and Bound (1967)

The problem of the optimal assignment of facilities to locaticns has been solved by J.W. Gavett and Normann V.Plyter. In their paper the branch and bound technique is used and for this purpose the distance matrix is transformed into the matrix whose diagonal compoents are zero. The purpose of this paper is to avoid such a transformation and the store of the distance matrix into the computer.
Failure of the International Normalized Ratio to Generate Consistent Results Within a Local Medical Community (1993)

Use of the International Normalized Ratio (INR) has been recommended as a means of standardizing prothrombin time (PT) results for management of oral anticoagulant therapy. During the evaluation of a new lot of thromboplastin reagent, however, INR values were obtained that were inconsistent with results obtained with the prior lot of reagent from the same manufacturer. A local normalized ratio (LNR) was substituted for the INR for the new reagent, based on a calculated local sensitivity index (LSI). Validation of the LSI was performed at the three hospitals in the medical community by testing an identical panel of aliquots from 64 plasmas obtained from patients who were chronically receiving oral anticoagulants. Each test result was classified according to the INR value as low, low therapeutic, high therapeutic, or high. Local normalized ratio values obtained at one hospital in the community were in reasonable agreement with INR determinations in the other two hospital laboratories. Classification mismatches occurred using the INR, however, in 84 of 280 (30%) of the paired samples. Thus, the inability to generate consistent INR values within a local medical community raises serious concern about the reliability of the INR concept in its current form.
A comparison of two partial matching strategies for classification of unseen cases (2006)

This paper compares two partial matching strate- gies, selective and mixed, for classification of unseen cases. The selective partial matching is a novel approach for classification, while mixed partial matching was implemented in the LERS classification system several years ago. Though results of our experiments show that neither strategy is better than the other, an important conclusion is that it is crucial to implement both strategies since the correct choice of one of these strategies, for a specific data set, results in substantial improvement of the final classification.
Development of the process parameter map for reference free part encapsulation (2001)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2001.
Recent developments in the psychobiology and pharmacotherapy of depression: optimising existing treatments and novel approaches for the future (2003)

AbstractEffective antidepressants include monoamine oxidase inhibitors and tricyclic antidepressants, selective serotonin re-uptake inhibitors and novel agents, including serotonin and noradrenaline re-uptake inhibitors. Although effective, current treatments most often produce partial symptomatic improvement (response) rather than symptom resolution and optimal functioning (remission). While current pharmacotherapies target monoaminergic systems, different symptoms of major depressive disorder (MDD) may have distinct neurobiological underpinnings and other neurobiological systems are likely involved in the pathogenesis of MDD. In this article a review of current pharmacotherapeutic options for MDD, current understanding of the neurobiology and pathogenesis of MDD and a review of new and promising directions in pharmacological research will be provided. It is generally accepted that no single neurotransmitter or system is responsible for the dysregulation found in MDD. While agents that affect monoaminergic systems will likely continue to be first-line treatments for MDD for the foreseeable future, a number of new and novel agents, including corticotropin-releasing factor antagonists, substance P antagonists and antiglucocorticoids show considerable promise for refining treatment options. In order to better understand the neurobiology and treatment response of MDD, it is probable that more sophisticated theory-driven typologies of MDD will have to be developed.affective disordersagonistsantagonistsantiglucocorticoidsbenzodiazepinesbrain-derived neurotrophic factorcorticotropin-releasing factordopaminedepressionGABAglutamatemonoamine oxidase inhibitorsneuropeptidesnicotinenoradrenalinepsychopharmacologyserotonin blockersserotonin re-uptake inhibitorsserotoninsubstance Ptreatmenttropic factors
Antitumour imidazotetrazines. Part 31. The synthesis of isotopically labelled temozolomide and a multinuclear (1H, 13C, 15N) magnetic resonance investigation of temozolomide and mitozolomide (1995)

The antitumour drug temozolomide has been synthesized isotopically labelled with NMR active nuclei at a variety of sites and all its 13C and 15N NMR spectral resonances have been assigned. At low pH a site of protonation has been identified which accounts for the acid stability of the drug
Characterization and Optimization of D-β-Hydroxybutyrate and Melatonin, a Treatment for Hemorrhagic Shock (2018)

University of Minnesota Ph.D. dissertation.February 2018. Major: Surgery. Advisor: Gregory Beilman. 1 computer file (PDF); xv, 198 pages.
Numerical analysis of AC loss in high T/sub c/ twisted tape carrying AC transport current in external AC magnetic field. Effect of twisting on loss reduction (1999)

The effect of twisting in BSCCO tapes on the loss reduction is discussed by a numerical analysis using the finite element method. The optimal twist pitch giving the lowest loss for the tape carrying the AC current under the AC magnetic field is presented. The numerical analysis takes the smooth E-j characteristics, the twisted structure and the dynamic resistivity into account, which allows more accurate loss estimations. For the BSCCO tape with a typical dimension of 3 mm/spl times/0.2 mm, the optimal twist pitch is around 10 mm, when it is carrying the AC transport current with normalized amplitude I/sub t//I/sub c/=0.8, under the parallel magnetic field to the tape face.
Immunostimulatory effect of faecal<i>Bifidobacterium</i>species of breast-fed and formula-fed infants in a peripheral blood mononuclear cell/Caco-2 co-culture system (2011)

Bifidobacterium spp. typical of the human intestinal microbiota are believed to influence the balance of immune responses in the intestinal mucosa. The aim of the present study was to investigate the effect of different bifidobacterial species and their mixtures in in vitro experiments with peripheral blood mononuclear cells (PBMC) and Caco-2 cells. Bifidobacterium adolescentis, B. angulatum, B. breve, B. catenulatum, B. infantis, B. longum and two combinations of these bifidobacteria simulating the species composition found in faecal samples from breast-fed (BF) and formula-fed (FF) infants were used. The levels of several cytokines were measured by direct stimulation of PBMC and by stimulation of a Caco-2/PBMC co-culture with bifidobacteria. B. catenulatum and B. breve were the strongest enhancers of interferon-γ (IFN-γ) production by direct stimulation of PBMC. B. longum was the highest inducer of IL-10 and the lowest TNF-α stimulus. In the Caco-2/PBMC system, B. breve was the highest inducer of IL-8 production by Caco-2 cells, significantly different from B. infantis, B. adolescentis and the FF mixture (P < 0·05). IFN-γ produced by PBMC stimulated with the BF mixture (containing 22 % B. breve, compared with 7 % in the FF mixture) was significantly higher compared with B. adolescentis, B. infantis and B. longum. B. adolescentis also inhibited IFN-γ production compared with the FF mixture and B. longum. The proportion of different Bifidobacterium strains seems to be an important determinant of the cytokine balance in the simulated intestinal environment studied. B. breve and the combination of the Bifidobacterium species typically found in the microbiota of BF infants have shown the most significant effects.
Flowstrates: An Approach for Visual Exploration of Temporal Origin‐Destination Data (2011)

Abstract Many origin‐destination datasets have become available in the recent years, e.g. flows of people, animals, money, material, or network traffic between pairs of locations, but appropriate techniques for their exploration still have to be developed. Especially, supporting the analysis of datasets with a temporal dimension remains a significant challenge. Many techniques for the exploration of spatio‐temporal data have been developed, but they prove to be only of limited use when applied to temporal origin‐destination datasets. We present Flowstrates , a new interactive visualization approach in which the origins and the destinations of the flows are displayed in two separate maps, and the changes over time of the flow magnitudes are represented in a separate heatmap view in the middle. This allows the users to perform spatial visual queries, focusing on different regions of interest for the origins and destinations, and to analyze the changes over time provided with the means of flow ordering, filtering and aggregation in the heatmap. In this paper, we discuss the challenges associated with the visualization of temporal origin‐destination data, introduce our solution, and present several usage scenarios showing how the tool we have developed supports them.
Association of Endothelin-1 Gene Variant With Hypertension (2003)

Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide produced by endothelial and smooth muscle cells. Many lines of biological evidence suggest that the ET-1 gene is a candidate gene for hypertension. Moreover, recent association studies suggested that a G/T polymorphism with an amino acid substitution (Lys/Asn) at codon 198 in exon 5 of the ET-1 gene interacts with body mass index (BMI) in association with blood pressure. They suggested that T carriers are more sensitive to weight gain than GG homozygotes in association with blood pressure. However, association studies are often irreproducible, and the first study often suggests a stronger genetic effect than is found by subsequent studies. We therefore assessed the interaction in 2 large Japanese populations. The present study showed a nonsignificant but similar trend to the results of previous reports. Moreover, in line with previous reports, this study revealed a significant interaction between the ET-1 K198N (G/T) polymorphism and BMI in association with hypertension in our populations (P=0.027). The interaction was significant, even after adjustment for gender and age (P=0.045) and for all confounding factors (P=0.044). T carriers were more sensitive to weight gain than GG homozygotes in association with hypertension. Considering the combined impact of obesity and hypertension on the development of cardiovascular and cerebrovascular disorders, T allele carriers might represent elective targets for therapy to lower their body weight.
The Neurofibromatosis 2 Protein, Merlin, Regulates Glial Cell Growth in an ErbB2- and Src-Dependent Manner (2008)

Individuals with the inherited cancer predisposition syndrome neurofibromatosis 2 (NF2) develop several central nervous system (CNS) malignancies, including glial cell neoplasms (ependymomas). Recent studies have suggested that the NF2 protein, merlin (or schwannomin), may regulate receptor tyrosine kinase signaling, intracellular mitogenic growth control pathways, or adherens junction organization in non-nervous-system cell types. For this report, we used glial fibrillary acidic protein conditional knockout mice and derivative glia to determine how merlin regulates CNS glial cell proliferation. We show that the loss of merlin in glial cells results in increased proliferation in vitro and in vivo. Merlin regulation of glial cell growth reflects deregulated Src activity, such that pharmacologic or genetic inhibition of Src activation reduces Nf2(-/-) glial cell growth to wild-type levels. We further show that Src regulates Nf2(-/-) glial cell growth by sequentially regulating FAK and paxillin phosphorylation/activity. Next, we demonstrate that Src activation results from merlin regulation of ErbB2 activation and that genetic or pharmacologic ErbB2 inhibition reduces Nf2(-/-) glial cell Src/Src effector activation and proliferation to wild-type levels. Lastly, we show that merlin competes with Src for direct binding to ErbB2 and present a novel molecular mechanism for merlin regulation of ErbB2-dependent Src signaling and growth control.
Characterization, Control and Compensation of MEMS Rate and Rate-Integrating Gyroscopes. (2012)

Inertial sensing has important applications in navigation, safety, and entertainment. Areas of active research include improved device structures, control schemes, tuning methods, and detection paradigms. A powerful and flexible characterization and control system built on commercial programmable hardware is especially needed for studying mode-matched gyroscopes and rate-integrated gyroscopes. A gyroscope can be operated in a mode-matched rate-mode for increased sensitivity or rate-integrating mode for greatly increased dynamic range and bandwidth, however control is challenging and the performance is sensitive to the matching of the modes. This thesis proposes a system built on open and inexpensive software-defined radio (SDR) hardware and open source software for gyroscope characterization and control. The characterization system measures ring-down of devices with damping times and automatically tunes the vibration modes from over 40 Hz mismatch to better than 100 mHz in 3 minutes. When used for rate-gyroscope operation the system provides an FPGA implementation of rate gyroscope control with amplitude, rate and quadrature closed-loop control in the SDR hardware which demonstrates 400% improvement in noise and stability over open-loop operation. The system also operates in a RIG mode with hybrid software/firmware control and demonstrates continuous operation for several hours, unlike previous systems which are limited by the gyroscope ring-down time. The hybrid mode also has a simulation module for development of advanced gyroscope control algorithms. Advanced controls proposed for RIG operation show over 1000% improvement in effective frequency and damping mismatch in simulation and 25% reduction in drift due to damping mismatch in a test RIG. By tuning the compensation, the drift can be reduced by almost 90%, with worst case drift decreased to -41 deg/s and RMS drift to -21 deg/s. Harmonic analysis of the anisotropy in a rate-integrating gyroscope measured with this control system is presented to guide development of new error models which will further improve performance.
Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk (2004)

Tobacco smoking and occupational exposure are major risk factors of bladder cancer via exposure to polycyclic aromatic hydrocarbons (PAHs) and aromatic amines, which lead to oxidative stress and DNA damage. Several enzymes, which play key roles in oxidative stress are polymorphic in humans. Myeloperoxidase (MPO) produces a strong oxidant for microbicidal activity, and activates carcinogens in tobacco smoke. Catechol-O-methyltransferase (COMT) catalyzes the methylation of endo- and xenobiotics and prevents redox cycling. NAD(P)H:quinone oxidoreductase (NQO1) catalyzes the two-electron reduction of quinoid compounds, which also protects cells from redox cycling. Manganese superoxide dismutase (MnSOD) protects cells from free radical injury. To test the hypothesis that the risk of bladder cancer can be influenced by polymorphisms in the genes that modulate oxidative stress, in particular by interacting with environmental carcinogens, we conducted a hospital-based case-control study among men in Brescia, Northern Italy. We recruited and interviewed 201 incident cases and 214 controls from 1997 to 2000. Occupational exposures to PAHs and aromatic amines were coded blindly by occupational physicians. Unconditional multivariate logistic regression was applied to model the association between genetic polymorphisms and bladder cancer risk and the effect of modifications of smoking and occupational exposures were evaluated. MPO G-463A homozygous variant was associated with a reduced risk of bladder cancer with an OR of 0.31 (95% CI = 0.12-0.80). MnSOD Val/Val genotype increased the risk of bladder cancer with OR of 1.91 (95% CI = 1.20-3.04), and there was a combined effect with smoking (OR = 7.20, 95% CI = 3.23-16.1) and PAH (OR = 3.02, 95% CI = 1.35-6.74). We did not observe an effect of COMT Val108Met polymorphism. These findings suggest that individual susceptibility of bladder cancer may be modulated by MPO and MnSOD polymorphisms, and that the combination of genetic factors involved in oxidative stress response with environmental carcinogens may play an important role in bladder carcinogenesis.
Two amino acid amidohydrolase genes encoding L-stereospecific carbamoylase and aminoacylase are organized in a common operon in Bacillus stearothermophilus (1997)

The L-carbamoylase gene (amaB) upstream of the previously detected L-aminoacylase gene (amaA) in the Bacillus stearothermophilus NCIB8224 strain was identified in this study. The amaB and amaA genes are cotranscribed as a single mRNA from the same transcriptional start. The two-ama-gene operon is conserved in B. stearothermophilus strains. A cross-activity of L-carbamoylase towards respective substrates for L-aminoacylase supports the hypothesis of a common ancestor for both amino acid amidohydrolase genes.
Impedance control of a teleoperated excavator (2002)

Earth-moving machines such as hydraulic excavators are usually used for carrying out contact tasks. Impedance control can be employed as an approach for achieving compliant motion in such tasks. This paper describes a position-based impedance controller that has been developed in our laboratory for excavator-type manipulators, and presents the supporting experimental results. First, the problem of impedance control for a single hydraulic cylinder is addressed and a method is presented to analyze the system stability. The steady-state position and force tracking accuracy of the closed-loop system is also studied. Next, the problem of impedance control for a multi-link hydraulic excavator is addressed and the arm Jacobian and accurate estimates of the arm inertial terms are employed to map the desired impedance of the end-effector (bucket of the excavator) onto the hydraulic cylinders. Various contact experiments carried out using an instrumented mini-excavator demonstrate that the proposed impedance controller has very good performance for both single-link and multilink cases.