gebhart/patrepeval huggingface dataset:
Music recommendation system based on user's sentiments extracted from social networks (2015)

In recent years, the sentiment analysis has been explored by several Internet services to recommend contents in accordance with human emotions, which are expressed through informal texts posted on social networks. However, the metrics used in the sentiment analysis only classify a sentence with positive, neutral or negative intensity, and do not detect sentiment variations in accordance with the user’s profile. In this arena, this paper presents a music recommendation system based on a sentiment intensity metric, named enhanced Sentiment Metric (eSM) that is the association of a lexicon-based sentiment metric with a correction factor based on the user’s profile. This correction factor is discovered by means of subjective tests, conducted in a laboratory environment. Based on the experimental results, the correction factor is formulated and used to adjust the final sentiment intensity. The users' sentiments are extracted from sentences posted on social networks and the music recommendation system is performed through a framework of low complexity for mobile devices, which suggests songs based on the current user’s sentiment intensity. Also, the framework was built considering ergonomic criteria of usability. The performance of the proposed framework is evaluated with remote users using the crowdsourcing method, reaching a rating of 91% of user satisfaction, outperforming a randomly assigned song suggestion that reached 65% of user satisfaction. Furthermore, the paper presents low perceived impacts on the analysis of energy consumption, network and latency in accordance with the processing and memory perception of the recommendation system, showing advantages for the consumer electronic world.
Image restoration using multiresolution texture synthesis and image inpainting (2004)

We present a new method for the restoration of digitized photographs. Restoration refers to removal of image defects such as scratches and blotches as well as to removal of disturbing objects as, for instance, subtitles, logos, wires, and microphones. Our method combines techniques from texture synthesis and image inpainting, bridging the gap between these two approaches that have recently attracted strong research interest. Combining image inpainting and texture synthesis in a multiresolution approach gives us the best of both worlds and enables us to overcome the limitations of each of those individual approaches. The restored images obtained with our method look plausible in general and surprisingly good in some cases. This is demonstrated for a variety of input images that exhibit different kinds of defects.
Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer. (1991)

A T-cell-specific transcriptional enhancer was previously identified within the J delta 3-C delta intron of the human T-cell receptor (TCR) delta gene, and seven distinct binding sites for nuclear factors (delta E1 to delta E7) were defined by DNase I footprinting. In this study, we conducted a detailed functional analysis of the various cis-acting DNA sequence elements of the enhancer and show that a 60-bp fragment encompassing delta E3 and delta E4 displays potent enhancer activity, as judged by its ability to activate transcription from the V delta 1 promoter. We show that the interaction of nuclear factors with the delta E3 site is essential for enhancer activity. This element displays significant activity in the absence of additional segments of the enhancer. Further, methylation interference and in vitro mutagenesis identify a site within delta E3 that mediates the binding of two nuclear factors (NF-delta E3A and NF-delta E3C) and that is required for significant transcriptional activation by the enhancer. NF-delta E3C is ubiquitous and may be identical to a previously characterized microE3-binding factor. NF-delta E3A is preferentially expressed in T lymphocytes, and we suggest that this factor may play the dominant role in transcriptional activation through the delta E3 site. This factor interacts with the sequence TGTGGTTT, a motif that is also found within the enhancers of additional TCR and CD3 genes. Nuclear factor binding to delta E4 is also analyzed. One of three specific complexes formed with a delta E4 probe appears to be T-cell specific.
Tactile sensory substitution: Models for enaction in HCI (2008)

To apply enactive principles within human–computer interaction poses interesting challenges to the way that we design and evaluate interfaces, particularly those that possess a strong sensorimotor character. This article surveys the field of tactile sensory substitution, an area of science and engineering that lies at the intersection of such research domains as neuroscience, haptics, and sensory prosthetics. It is argued that this area of research is of high relevance to the design and understanding of enactive interfaces that make use of touch, and is also a fertile arena for revealing fundamental issues at stake in the design and implementation of enactive interfaces, ranging from engineering, to human sensory physiology, and the function and plasticity of perception. A survey of these questions is provided, alongside a range of current and historical examples.
Storage of Information Using Small Organic Molecules (2019)

Although information is ubiquitous, and its technology arguably among the highest that humankind has produced, its very ubiquity has posed new types of problems. Three that involve storage of information (rather than computation) include its usage of energy, the robustness of stored information over long times, and its ability to resist corruption through tampering. The difficulty in solving these problems using present methods has stimulated interest in the possibilities available through fundamentally different strategies, including storage of information in molecules. Here we show that storage of information in mixtures of readily available, stable, low-molecular-weight molecules offers new approaches to this problem. This procedure uses a common, small set of molecules (here, 32 oligopeptides) to write binary information. It minimizes the time and difficulty of synthesis of new molecules. It also circumvents the challenges of encoding and reading messages in linear macromolecules. We have encoded, written, stored, and read a total of approximately 400 kilobits (both text and images), coded as mixtures of molecules, with greater than 99% recovery of information, written at an average rate of 8 bits/s, and read at a rate of 20 bits/s. This demonstration indicates that organic and analytical chemistry offer many new strategies and capabilities to problems in long-term, zero-energy, robust information storage.
Treating C3 glomerulopathy with eculizumab (2018)

Eculizumab may be a therapeutic option for a subset of C3G patients. The response to eculizumab is heterogeneous, and early as well as continuous treatment may be necessary to prevent disease progression. These findings emphasize the need for studies identifying genetic and functional complement abnormalities that may help to guide eculizumab treatment and predict response.
FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells (2009)

Novel immunomodulatory molecule FTY720 is a synthetic analog of myriocin, but unlike myriocin FTY720 does not inhibit serine palmitoyltransferase. Although many of the effects of FTY720 are ascribed to its phosphorylation and subsequent sphingosine 1-phosphate (S1P)-like action through S1P(1,3-5) receptors, studies on modulation of intracellular balance of signaling sphingolipids by FTY720 are limited. In this study, we used stable isotope pulse labeling of human pulmonary artery endothelial cells with l-[U-(13)C, (15)N]serine as well as in vitro enzymatic assays and liquid chromatography-tandem mass spectrometry methodology to characterize FTY720 interference with sphingolipid de novo biosynthesis. In human pulmonary artery endothelial cells, FTY720 inhibited ceramide synthases, resulting in decreased cellular levels of dihydroceramides, ceramides, sphingosine, and S1P but increased levels of dihydrosphingosine and dihydrosphingosine 1-phosphate (DHS1P). The FTY720-induced modulation of sphingolipid de novo biosynthesis was similar to that of fumonisin B1, a classical inhibitor of ceramide synthases, but differed in the efficiency to inhibit biosynthesis of short-chain versus long-chain ceramides. In vitro kinetic studies revealed that FTY720 is a competitive inhibitor of ceramide synthase 2 toward dihydrosphingosine with an apparent K(i) of 2.15 microm. FTY720-induced up-regulation of DHS1P level was mediated by sphingosine kinase (SphK) 1, but not SphK2, as confirmed by experiments using SphK1/2 silencing with small interfering RNA. Our data demonstrate for the first time the ability of FTY720 to inhibit ceramide synthases and modulate the intracellular balance of signaling sphingolipids. These findings open a novel direction for therapeutic applications of FTY720 that focuses on inhibition of ceramide biosynthesis, ceramide-dependent signaling, and the up-regulation of DHS1P generation in cells.
Increased basal intracellular signaling patterns do not correlate with JAK2 genotype in human myeloproliferative neoplasms (2011)

Myeloproliferative neoplasms (MPNs) are associated with recurrent activating mutations of signaling proteins such as Janus kinase 2 (JAK2). However, the actual downstream signaling events and how these alter myeloid homeostasis are poorly understood. We developed an assay to measure basal levels of phosphorylated signaling intermediates by flow cytometry during myeloid differentiation in MPN patients. Our study provides the first systematic demonstration of specific signaling events and their comparison with disease phenotype and JAK2 mutation status. We demonstrate increased basal signaling in MPN patients, which occurs in both early and later stages of myeloid differentiation. In addition, the pattern of signaling is not correlated with JAK2 mutation status and signaling intensity is poorly correlated with mutant JAK2 allele burden. In contrast, signaling differences are detected between different MPN disease phenotypes. Finally, we demonstrate that signaling can be inhibited by a JAK2-selective small molecule, but that this inhibition is not JAK2 V617F specific, because MPN patients with mutant JAK2, wild-type JAK2, and control patients were inhibited to a similar degree. Our data suggest that, in addition to JAK2 mutations, other factors contribute significantly to the MPN phenotype, results that are relevant to both the pathogenesis and therapy of MPN.
A small OCA on a 1/spl times/0.5-mm/sup 2/ 2.45-GHz RFID Tag-design and integration based on a CMOS-compatible manufacturing technology (2006)

This letter reports, for the first time, on the design strategy and process integration for a small on-chip-antenna (OCA) with a radio-frequency identification (RFID) tag chip-area /spl sim/1/spl times/0.5 mm/sup 2/. It is designed based on a 2.45-GHz RFID tag circuit with an inductive-coupling model. A patterned Al shielding layer is used to improve the consistency of the actual performance obtained from fabricated devices and those predicated from the design. The antenna's inductor coils were fabricated based on a conventional Cu-Damascene process. To achieve the required antenna performance (e.g., Q-factor), a set of thick USG and deep-via etch processes were specifically developed. Our results demonstrate that the dc power converted by the OCA is sufficient to enable the RFID tag chip to communicate with a corresponding 2.45-GHz RFID reader with a 1-mm distance.
Enhancement of light extraction from GaN-based green light-emitting diodes using selective area photonic crystal (2010)

We report the development of a GaN-based green light-emitting diode (LED) with a selective area photonic crystal (SPC) structure, which was formed outside the p-bonding electrode on p-GaN. As a result, the optical output power of LEDs with SPC was enhanced by 78% compared to that without PC. In addition, the forward voltage, series resistance, and leakage current of LEDs with SPC were remarkably improved. These results show that the light extraction efficiency of green LEDs can be greatly increased using the SPC structure, with no degradation of electrical properties.
Using the Localized Surface Plasmon Resonance of Gold Nanoparticles To Monitor Lipid Membrane Assembly and Protein Binding (2013)

Gold nanoparticles provide a template for preparing supported lipid layers with well-defined curvature. Here, we utilize the localized surface plasmon resonance (LSPR) of gold nanoparticles as a sensor for monitoring the preparation of lipid layers on nanoparticles. The LSPR is very sensitive to the immediate surroundings of the nanoparticle surface and it is used to monitor the coating of lipids and subsequent conversion of a supported bilayer to a hybrid membrane with an outer lipid leaflet and an inner leaflet containing hydrophobic alkanethiol. We demonstrate that both decanethiol and propanethiol are able to form hybrid membranes and that the membrane created over the shorter thiol can be stripped from the gold along with the lipid leaflet using β-mercaptoethanol. The sensitivity of the nanoparticle LSPR to the refractive index (RI) of its surroundings is greater when the shorter thiol is used (37.8 ± 1.5 nm per RI unit) than when the longer thiol is used (27.5 ± 0.5 nm per RI unit). Finally, C-reactive protein binding to the membrane is measured using this sensor allowing observation of both protein-membrane and nanoparticle-nanoparticle interactions without chemical labeling of protein or lipids.
Clinical Correlates of Response to Botulinum Toxin Injections (1991)

We studied 242 patients with cervical dystonia who had adequate follow-up after botulinum toxin injections to determine which clinical variables had a predictive value in the treatment outcome. Twenty-one patients (16%) categorized as nonresponders were compared with 113 patients (47%) considered to be definite responders. On average, the nonresponders had symptoms for 14 years longer than responders. Seventy-eight of 100 patients with complications were female compared with 54% of 190 patients without complications. In addition, patients with complications weighed less than those without complications. Both findings suggest that the occurrence of complications is related to smaller mean neck muscle mass. Botulinum toxin antibodies were detected in 35.7% of the nonresponders tested and in none of the responders. This comprehensive analysis of outcome variables leads us to conclude that patients with a long duration of dystonia before their first botulinum toxin injection respond less well than those with a short duration of symptoms, that some patients lose their responsiveness because of the development of blocking antibodies, and that women are more likely to develop complications, such as dysphagia and neck weakness, than are men.
Image Registration Using Adaptive Polar Transform (2009)

Image registration is an essential step in many image processing applications that need visual information from multiple images for comparison, integration, or analysis. Recently, researchers have introduced image registration techniques using the log-polar transform (LPT) for its rotation and scale invariant properties. However, it suffers from nonuniform sampling which makes it not suitable for applications in which the registered images are altered or occluded. Inspired by LPT, this paper presents a new registration algorithm that addresses the problems of the conventional LPT while maintaining the robustness to scale and rotation. We introduce a novel adaptive polar transform (APT) technique that evenly and effectively samples the image in the Cartesian coordinates. Combining APT with an innovative projection transform along with a matching mechanism, the proposed method yields less computational load and more accurate registration than that of the conventional LPT. Translation between the registered images is recovered with the new search scheme using Gabor feature extraction to accelerate the localization procedure. Moreover an image comparison scheme is proposed for locating the area where the image pairs differ. Experiments on real images demonstrate the effectiveness and robustness of the proposed approach for registering images that are subjected to occlusion and alteration in addition to scale, rotation, and translation.
Systematic granulomas caused by a rickettsia‐like organism in Nile tilapia, <i>Oreochronuis niloticus</i> (L.), from southern Taiwan (1994)

Abstract. A rickettsia‐like organism was observed in diseased Nile tilapia, Oreochronuis niloticus (L.), from southern Taiwan. Most affected fish were pale and lethargic with haemorrhages and ulcers on the skin. The most significant gross pathological changes were varying degrees of ascites, and enlargement of the spleen, kidney and liver. Marked white nodules (as ring‐shaped foci), varying in size, were found in these organs. A Gram‐negative, rickettsia‐like organism (RLO) frequently appeared as inclusions or within host cell intra‐cytoplasmic vacuoles. Fibrin thrombi, perivascular necrosis, chronic inflammatory cells with hypertrophy and RLO‐laden cells were characteristic of the disease. White nodules induced in experimental fish were similar to naturally infected cases and RLOs were reisolated in tissue culture using a CHSE‐214 cell line. This provides evidence that the systemic granulomas in Nile tilapia were caused by RLOs.
Effects of Ethylene on Auxin Transport (1966)

The effect of ethylene on the uptake, distribution and polar transport of C(14) from indole-3-acetic acid-2-C(14) and naphthalene acetic acid-1-C(14) in tissue sections was studied. Test species were cotton (Gossypium hirsutum, L.) and cowpea (Vigna sinensis, Endl.). Generally, incubation of tissue or intact plants with ethylene reduced the degree of polar auxin transport. Ethylene inhibited the movement of both auxins in stem tissue and IAA in petiole tissue of cotton. The effect of ethylene on auxin movement in cow-peas was more complex. Ethylene apparently inhibited transport in younger petiole and stem tissue, but stimulated the process to a small but significant degree in basal petiole segments.Ethylene, in some experiments, reduced C(14) (auxin) uptake. This reduction was consistently smaller than the inhibition of transport. Effects upon transport were observed when uptake was not different. Differences in uptake declined as the period of incubation with auxin was lengthened, but transport was inhibited for up to 23 hours.It is proposed that ethylene may, through its effect on transport, cause localized shortages and surpluses of auxin which in turn contribute to symptoms now associated with the response of sensitive species to ethylene.
Delayed Repolarization Underlies Ventricular Arrhythmias in Rats With Heart Failure and Preserved Ejection Fraction (2017)

Susceptibility to VA was markedly increased in rats with HFpEF. Underlying abnormalities include QT prolongation, delayed repolarization from downregulation of potassium currents, and multiple reentry circuits during VA. Our findings are consistent with the hypothesis that potassium current downregulation leads to abnormal repolarization in HFpEF, which in turn predisposes to VA and sudden cardiac death.
The Doherty Power Amplifier: Review of Recent Solutions and Trends (2015)

In this paper, an extensive review of the most up-to-date papers on microwave Doherty power amplifiers is presented. The main applications are discussed, together with the employed semiconductor technologies. The different research trends, all aimed to improve the advantages of the Doherty scheme and to solve its inherent drawbacks, are presented. The first considered topic is the maximization of efficiency and/or linearity, where analog and digital techniques are exploited. Another important trend is the bandwidth enlargement of the Doherty architecture, that involves a large number of papers. Multi-band, multi-mode solutions are also considered, using either fixed or reconfigurable solutions. The final section is dedicated to the most significant Doherty integrated implementations.
Analysis of Meningococcal Serogroup C-Specific Antibody Levels in British Columbian Children and Adolescents (1996)

The effects of age, sex, and possible prior exposure to serogroup C meningococci on group C-specific antibody levels (total and functional) were examined in 2- to 19-year-olds just before and 1 and 12 months after immunization with divalent (groups A + C) meningococcal capsular polysaccharide vaccine. Only age was found to have a significant effect on antibody levels. At 1 month, only 50% of 2- to 6-year-olds had detectable serum bactericidal antibody, in contrast to 84.1% and 96.3% of 9- to 12- and 13- to 19-year-olds respectively. By 12 months, only 20%, 40.9%, and 53.8% of subjects in these age groups had serum bactericidal antibody, suggesting that current meningococcal C polysaccharide vaccines provide only short-term protection. However, the drop in total specific antibody levels (by EIA) was less pronounced. Persistence of antibodies detectable by EIA (but not serum bactericidal antibodies) suggests that this vaccine may also give rise to antibodies of low affinity or directed to nonfunctional (nonprotective) epitopes (or both).
Regulatory T-Cells and Associated Pathways in Metastatic Renal Cell Carcinoma (mRCC) Patients Undergoing DC-Vaccination and Cytokine-Therapy (2012)

Immune monitoring of the peripheral blood and tumor tissue is important for a wide range of diseases and treatment strategies. Adoption of methodology for quantifying T(REG) with the least variability and subjectivity will enhance the ability to compare and interpret findings across studies.
Analysis and design of single-phase PFC converters for airborne systems (2004)

The stringent limits on harmonic current distortion for airborne equipment call for the development of power-factor-corrected (PFC) ac-dc converters with performance not offered by existing designs for terrestrial applications. The design challenge is further compounded by the use of high-frequency (400 Hz at the present, 360-800 Hz variable frequency in the future) ac sources. Different causes that contribute to input current distortions of single-phase PFC converters are analyzed in this paper to develop a quantitative understanding of various distortion generation mechanisms. Particular emphasis is placed on current harmonic distortion around zero crossing points of the input voltage. A new cause for current crossover distortion is discussed based upon a simple analytical model of the current control loop. Cusp distortion, distortion due to discontinuous conduction mode of operation, and the effects of dc-side filter capacitor are also discussed. Various distortion reduction techniques, including adding a phase delay to the reference, adaptive current loop gain, and feedforward control, are presented along with numerical simulation and experimental results to validate the analysis.
Thermal Reactions of Diisocyanate (MDI) with Phenols and Benzylalcohols: DSC Study and Synthesis of MDI Adducts (1993)

Article Thermal Reactions of Diisocyanate (MDI) with Phenols and Benzylalcohols: DSC Study and Synthesis of MDI Adducts was published on January 1, 1993 in the journal Holzforschung (volume 47, issue 5).