gebhart/patrepeval huggingface dataset:
Windows NT troubleshooting (1998)

Windows NT troubleshooting , Windows NT troubleshooting , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Continuous flow microreactors for drug discovery. (2004)

This article reviews the use of microreactors in the field of organic and combinatorial synthesis with regard to drug discovery applications. Research conducted into microreactors that enable in situ purification is described, and it is proposed that compounds could potentially be screened within an integrated bioassay system. A description of how it would be possible to use this technology to prepare larger quantities of pharmaceutical intermediates is also given.
Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice (2011)

We used a retroviral integration screen to search for novel genes that regulate HSC function. One of the genes that conferred HSC dominance when overexpressed due to an adjacent retroviral insertion was Musashi 2 (Msi2), an RNA-binding protein that can act as a translational inhibitor. A gene-trap mouse model that inactivates the gene shows that Msi2 is more highly expressed in long-term (LT) and short-term (ST) HSCs, as well as in lymphoid myeloid primed progenitors (LMPPs), but much less in intermediate progenitors and mature cells. Mice lacking Msi2 are fully viable for up to a year or more, but exhibit severe defects in primitive precursors, most significantly a reduction in the number of ST-HSCs and LMPPs and a decrease in leukocyte numbers, effects that are exacerbated with age. Cell-cycle and gene-expression analyses suggest that the main hematopoietic defect in Msi2-defective mice is the decreased proliferation capacity of ST-HSCs and LMPPs. In addition, HSCs lacking Msi2 are severely impaired in competitive repopulation experiments, being overgrown by wild-type cells even when mutant cells were provided in excess. Our data indicate that Msi2 maintains the stem cell compartment mainly by regulating the proliferation of primitive progenitors downstream of LT-HSCs.
VAPOR PRESSURES OF ORGANIC CRYSTALS BY AN EFFUSION METHOD (1925)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVAPOR PRESSURES OF ORGANIC CRYSTALS BY AN EFFUSION METHODThomas H. Swan and Edward Mack Jr.Cite this: J. Am. Chem. Soc. 1925, 47, 8, 2112–2116Publication Date (Print):August 1, 1925Publication History Published online1 May 2002Published inissue 1 August 1925https://doi.org/10.1021/ja01685a005RIGHTS & PERMISSIONSArticle Views298Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (345 KB) Get e-Alertsclose Get e-Alerts
Advances in mathematical models for image processing (1981)

Several state-of-the-art mathematical models useful in image processing are considered. These models include the traditional fast unitary transforms, autoregessive and state variable models as well as two-dimensional linear prediction models. These models introduced earlier [51], [52] as low-order finite difference approximations of partial differential equations are generalized and extended to higher order in the framework of linear prediction theory. Applications in several image Processing problems, including image restoration, smoothing, enhancement, data compression, spectral estimation, and filter design, are discussed and examples given.
Reflection of Wave Trains in Semi-Infinite Plates (1967)

A method for using the well known modes of vibration for the infinite plate as elements of an expansion applicable to semi-infinite plates is given. The method is employed to study the reflection of an infinite train of waves from the free edge of an elastic plate. The incident train of waves induces other, nonpropagating, modes. As has previously been discovered, a resonance may occur in such a mode that will increase the portion of the plate for which the evanescent modes affect the stress distribution. Above a critical frequency, a transfer of energy from one propagating mode to another occurs during the reflection. Generally, energy brought to a free edge by waves of one wavelength will depart in wave trains of several different wavelengths. The presence of a mode which, for a limited range of frequency, carries energy in a direction opposite to the motion of the waves is confirmed. Some observations are made about necessary restrictions in an extension of St. Venant's principle to dynamic loadings.
Thermal conduction in metallized silicon-dioxide layers on silicon (1994)

The vertical thermal conductivities of thermally grown (TG) and chemical vapor deposited (CVD) silicon-dioxide layers 20 to 200 nm thick are measured using a simple, noncontact photothermal technique. The conductivities of TG and CVD layers are less by as much as 18% and 30%, respectively, than the conductivity of bulk fused silicon dioxide. No significant thickness dependence is observed. The thermal boundary resistance between the oxide layers and silicon is shown to be negligibly small. The boundary resistance of gold layers sputtered directly onto TG oxide is considerably larger than that of gold layers evaporated on TG oxide with a 20-nm chromium adhesion layer, and is comparable to internal resistances of the oxide layers.
A Mixed-Signal Matching State Search Based Adaptive Antenna Tuning IC (2010)

A closed-loop adaptive antenna tuning unit operating from 850 MHz-2 GHz for multi-band, multi-mode radios is presented. Unlike previous approaches, the proposed module utilizes an analog mismatch detector and a closed-loop mixed-signal matching state search circuit, without the need for an A/D converter. The integrated module is designed and fabricated on a 0.18 CMOS process. When tested on a band-limited shorted patch antenna, the module can perform a scan of 4096 antenna matching states in 4.1 ms, and tune the antenna to a specified narrow instantaneous bandwidth over the entire frequency range.
Digital signature with localization for image authentication (2011)

This paper proposes a method of extracting a digital signature that can localize tampered areas. The method of generating the digital signature of an image is based on the regularity properties of wavelet transform coefficients.
La colle Caurite et son utilisation dans les industries du bois (2010)

International audience
Beyond multi-class – structured learning for machine translation (2010)

In this thesis, we explore and present machine learning (ML) approaches to a particularly challenging research area – machine translation (MT). The study aims at replacing or developing each component in the MT system with an appropriate discriminative model, where the ultimate goal is to create a powerful MT system with cutting-edge ML techniques.\n\nThe study regards each sub-problem encountered in the MT field as a classification or regression problem. To model specific mappings in MT tasks, the modern machine learning paradigm known as “structured learning” is pursued. This approach goes beyond classic multiclass pattern classification and explicitly models certain dependencies in the target domain.\n\nDifferent algorithmic variants are then proposed for constructing the ML-based MT systems: the first application is a kernel-based MT system, that projects both input and output into a very high-dimensional linguistic feature space and makes use of the maximum margin regression (MMR) technique to learn the relations between input and output. It is amongst the first MT systems that work with pure ML techniques. The second application is the proposal of a max-margin structure (MMS) approach to phrase translation probability modelling in an MT system. The architecture of this approach is shown to capture structural aspects of the problem domains, leading to demonstrable performance improvements on machine translation. Finally the thesis describes the development of a phrase reordering model for machine translation, where we have compared different ML methods and discovered a particularly efficient paradigm to solve this problem.
Vascular tissue generation in response to signaling molecules integrated with a novel poly(ɛ-caprolactone)–fibrin hybrid scaffold (2007)

A major constraint in the use of biodegradable polymer scaffolds for vascular tissue engineering is poor cell adhesion and lack of signals for new tissue generation. The presence of extracellular matrix (ECM) within the scaffold is desirable for growth of endothelial cells and in vitro formation of remodelled vascular conduit. In this study, we have produced a hybrid scaffold by coating porous poly-caprolactone (PCL) film with biomimetic ECM components consisting of fibrin, gelatin, fibronectin, angiogenic growth factors and proteoglycans. Human umbilical vein endothelial cells (HUVECs) adhered, spread, proliferated and survived for long periods in culture on the hybrid scaffold. As compared to bare PCL, enhanced cell adhesion, spreading and cytoskeletal organization were demonstrated on the hybrid scaffold, using confocal microscopy of EC-actin stained with Texas red-conjugated phalloidin. Population doubling of endothelial cells (ECs) on the hybrid scaffold and bare scaffold was estimated as 42 h and 136 h, respectively, as assessed by a 3H-thymidine uptake method. Analysis of proliferating cell nuclear antigen (PCNA) also indicated low proliferation on bare scaffold. Flow cytometric analysis of annexin V-stained cells showed poor survival of ECs on bare PCL as compared to the hybrid scaffold. Deposition of insoluble collagen and elastin was identified on the hybrid scaffold by cells recovered after 15 days and 30 days of EC culture, using fluorochrome-tagged specific antibodies and confocal microscopy, and the fluorescence intensity corresponding to elastin and collagen after 30 days was similar to that of 15 days. The results indicate that ECM deposition by endothelial cells is a regulated process without excessive accumulation after 30 days.
Experimental study of proximity effect corrections in electron-beam lithography (1995)

The computer aided proximity effect correction program CAPROX has been used to correct structures written at 20 keV electron beam energy. A new method has been developed to determine proximity parameters for a given e-beam/resist/substrate system. Proximity parameters for PMMA and EBR-9 and chemically amplified negative resist AZPN114 have been determined, and compared with those obtained from the established 'doughnut method'. The new method provides more reliable and accurate values, particularly for the forward scattering range. The dependence of (alpha) , (beta) and (eta) on resist thickness was also measured and the sensitivity of proximity correction using CAPROX to variation in all three scattering parameters was demonstrated. The new method improves CD linewidth linearity and accuracy in the range 0.1 approximately equals 4.0 micrometers , achieving linewidth for both lines and gaps within 100 nm of designed size.
Strawberry Modulates LDL Oxidation and Postprandial Lipemia in Response to High-Fat Meal in Overweight Hyperlipidemic Men and Women (2010)

The present results support a role for strawberry in mitigating fed-state oxidative stressors that may contribute to atherogenesis.
Viral long terminal repeat substrate binding characteristics of the human immunodeficiency virus type 1 integrase. (1994)

A DNA binding assay was developed for the human immunodeficiency virus type 1 (HIV-1) integrase. The assay was capable of defining discrete complexes between the enzyme and the viral long terminal repeat (LTR) substrate. DNA binding reflected the sequence requirements previously demonstrated for the enzyme's 3'-end processing activity. Binding exhibited a nonlinear dependence on integrase concentration, suggesting that the enzyme functions as a multimer. The oligomeric state was investigated by UV-photo-cross-linking of integrase-LTR oligonucleotide complexes using DNA substrates substituted with 5-bromo-2'-deoxycytidine within the integrase recognition sequence. In the absence of divalent cation, integrase cross-linked to the LTR oligonucleotide as a single species whose mobility by SDS-polyacrylamide gel electrophoresis was consistent with the formation of tetramers. Using these techniques, analysis of the binding properties of integrase mutants demonstrated that the catalytic and sequence-specific DNA binding activities of the enzyme are distinct, involving residues within the conserved "DD(35)E" and zinc finger motifs, respectively.
Clinical Evaluation and Parental Satisfaction with Pediatric Zirconia Anterior Crowns. (2016)

Zirconia crowns are clinically acceptable restorations in the primary maxillary anterior dentition. Parental satisfaction with zirconia crowns is high.
The bHLH genes <i>GLABRA3 (GL3)</i> and <i>ENHANCER OF GLABRA3(EGL3)</i> specify epidermal cell fate in the <i>Arabidopsis</i> root (2003)

The position-dependent specification of the hair and non-hair cell types in the Arabidopsis root epidermis provides a simple model for the study of cell fate determination in plants. Several putative transcriptional regulators are known to influence this cell fate decision. Indirect evidence from studies with the maize R gene has been used to suggest that a bHLH transcription factor also participates in this process. We show that two Arabidopsis genes encoding bHLH proteins, GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3), act in a partially redundant manner to specify root epidermal cell fates. Plants homozygous for mutations in both genes fail to specify the non-hair cell type, whereas plants overexpressing either gene produce ectopic non-hair cells. We also find that these genes are required for appropriate transcription of the non-hair specification gene GL2 and the hair cell specification gene CPC, showing that GL3 and EGL3 influence both epidermal cell fates. Furthermore, we show that these bHLH proteins require a functional WER MYB protein for their action, and they physically interact with WER and CPC in the yeast two-hybrid assay. These results suggest a model in which GL3 and EGL3 act together with WER in the N cell position to promote the non-hair cell fate, whereas they interact with the incomplete MYB protein CPC in the H position, which blocks the non-hair pathway and leads to the hair cell fate.
Hemostatic control of scalp incisions (1989)

A method is described to control bleeding from scalp incisions made for cranial surgery. The technique is simple and shortens the total length of time required for the procedure.
Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs (2007)

Chinese tonifying herbs such as herba cistanche, ganoderma and cordyceps, which possess antioxidant and/or immunomodulatory activities, can be useful in the prevention and treatment of age-related diseases. Pharmacological studies on Yang and Yin tonifying herbs suggest that Yang tonifying herbs stimulate mitochondrial adenosine triphosphate (ATP) generation, presumably through the intermediacy of reactive oxidant species, leading to the enhancement of cellular/mitochondrial antioxidant status. Yin tonifying herbs, however, apart from possessing antioxidant properties, exert mainly immunomodulatory functions that may boost a weak immune system and may also suppress overreactive immune responses. The abilities of Yang and Yin Chinese tonifying herbs to enhance ATP generation and to exhibit antioxidant and/or immunomodulatory actions are the pharmacological basis for their beneficial effects on the retardation of aging.
Biological Activity of Novel Macrocyclic Alkaloids (Budmunchiamines) from Albizia amara Detected on the Basis of Interaction with DNA (1991)

Extracts derived from Albizia amara were found to demonstrate activity in a recently developed hplc system designed to detect compounds capable of interacting with DNA. Further investigation led to the procurement of four sets of alkaloid isolates X1-X4 that were found to be macrocyclic pithecolobine alkaloids. All four isolates interacted with calf thymus DNA and were generally cytotoxic with a battery of cultured mammalian cells. As determined with Salmonella typhimurium strain TM677, isolates X1 and X3 were bactericidal, but not mutagenic. Isolate X1 was found to inhibit the catalytic activity of DNA polymerase, RNA polymerase, and HIV-1 reverse transcriptase. With DNA polymerase, the reaction was shown to be inhibited in a manner that was competitive with respect to DNA. In addition, isolate X1 inhibited each of the following: platelet aggregation, human lymphocyte transformation, phorbol-ester-induced chemiluminescence with human granulocytes, and cyclooxygenase activity. Detection of these alkaloids on the basis of their interaction with DNA exemplifies the validity of this approach.
Commercial databases: the Keypoints and practical use. (10). Patent and trade mark. (1994)

工業所有権に係る情報の価値とそのデータベースの活用法をエンドユーザの立場から解説した。特許情報は権利そのものの情報であるとともに,技術情報としての価値を有している。そしてまた企業の経営戦略においても重要な役割を持っている。情報としての量も他のデータベースに比べ格段に多く,その利用方法も多面的かつ複雑である。本稿ではパテントマップ作成,権利調査,技術動向解析,企業動向分析,SDI/ウォッチングなどについて論及した。また最近のCD-ROMによる公報発行をめぐる動きなどにも触れた。
Biophysical Response to Pulsed Laser Microbeam‐Induced Cell Lysis and Molecular Delivery (2007)

Cell lysis and molecular delivery in confluent monolayers of PtK(2) cells are achieved by the delivery of 6 ns, lambda = 532 nm laser pulses via a 40x, 0.8 NA microscope objective. With increasing distance from the point of laser focus we find regions of (a) immediate cell lysis; (b) necrotic cells that detach during the fluorescence assays; (c) permeabilized cells sufficient to facilitate the uptake of small (3 kDa) FITC-conjugated Dextran molecules in viable cells; and (d) unaffected, viable cells. The spatial extent of cell lysis, cell detachment, and molecular delivery increased with laser pulse energy. Hydrodynamic analysis from time-resolved imaging studies reveal that the maximum wall shear stress associated with the pulsed laser microbeam-induced cavitation bubble expansion governs the location and spatial extent of each of these regions independent of laser pulse energy. Specifically, cells exposed to maximum wall shear stresses tau(w, max) > 190 +/- 20 kPa are immediately lysed while cells exposed to tau(w, max) > 18 +/- 2 kPa are necrotic and subsequently detach. Cells exposed to tau(w, max) in the range 8-18 kPa are viable and successfully optoporated with 3 kDa Dextran molecules. Cells exposed to tau(w, max) < 8 +/- 1 kPa remain viable without molecular delivery. These findings provide the first direct correlation between pulsed laser microbeam-induced shear stresses and subsequent cellular outcome.
Rat models as tool to develop new immunotherapies (2001)

Rat models (experimental autoimmune encephalomyelitis, EAE; myasthenia gravis, EAMG) have been developed that mimic certain aspects of the pathophysiology of multiple sclerosis (MS) and myasthenia gravis (MG) in humans. Rat EAE and EAMG are, therefore, widely used to evaluate immunotherapeutic strategies. Mucosal tolerance induced by oral or nasal administration of autoantigen effectively suppresses rat EAE and EAMG. Nasal administration of the cytokines interleukin (IL)-4, IL-10 or transforming growth factor (TGF)-beta1 also ameliorates clinical signs of rat EAE. However, neither mucosal tolerance nor cytokines affect clinical disease if administered during ongoing rat EAE or EAMG. Dendritic cells (DC) pulsed in vitro with autoantigen can mediate peripheral tolerance against rat EAE and EAMG, but do not affect ongoing EAE or EAMG. DC from healthy rats, modified in vitro by exposure to IFN-gamma or TGF-beta1, effectively suppress ongoing EAE and EAMG when given by the subcutaneous route. Most importantly, DC from EAMG rats, after being modified in vitro with IL-10, also inhibit ongoing rat EAMG. These results demonstrate that different strategies influencing T- and/or B-cell responses in rat EAE or EAMG are available, but that DC-based immunotherapies are the most promising, in order to ameliorate ongoing organ-specific autoaggressive immunity Based on these observations, autologous DC, after being modified in vitro with cytokines, constitute a basis for new immunotherapeutic strategies in MS, MG and other diseases with autoimmune background.
Pilot Study of the Effects of Intermittent Interleukin‐2 on Human Immunodeficiency Virus (HIV)–Specific Immune Responses in Patients Treated during Recently Acquired HIV Infection (2002)

Highly active antiretroviral therapy (HAART) initiated during acute human immunodeficiency virus (HIV) infection may preserve HIV-specific CD4+ T cell responses that are thought to enhance HIV-specific CD8+ T cell function. The present pilot study was designed to determine whether preserved HIV-specific immune responses are augmented by the administration of the immunomodulatory agent interleukin (IL)-2. Nine persons recently (<6 months) infected with HIV were randomized to receive HAART alone or HAART plus 3 cycles of intermittent IL-2 during a 12-month period. Although HAART plus IL-2 significantly increased counts of total and naive CD4+ T cells, compared with HAART alone, there was no increase in CD4+ or CD8+ HIV-specific immune responses. In addition, adjuvant IL-2 therapy did not reduce the pool of HIV-infected resting CD4+ T cells. Thus, although intermittent IL-2 plus HAART quantitatively increased CD4+ T cells, this increase was not selective for HIV-specific CD4+ or CD8+ T cell responses in recently infected persons.
Intensity and phase statistics of multilook polarimetric and interferometric SAR imagery (1994)

Polarimetric and interferometric SAR data are frequently multilook processed for speckle reduction and data compression. The statistical characteristics of multilook data are quite different from those of single-look data. The authors investigate the statistics of their intensity and phase. Probability density function (PDF's) of the multilook phase difference, magnitude of complex product, and intensity and amplitude ratios between two components of the scattering matrix are derived, and expressed in closed forms. The PDF's depend on the complex correlation coefficient and the number of looks. Comparisons of these theoretically derived PDF's are made to measurements from NASA/JPL AIRSAR data. The results of this paper can be applied to feature classification using polarimetric SAR and to the estimation of decorrelation effects of the interferometric SAR.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Going beyond the self-assembled monolayer: metal intercalated dithiol multilayers and their conductance (2014)

A study of the configuration and the conductivity of the self-assembly of silver intercalated dithiol (DTT) monolayers and multilayers on gold is presented.