gebhart/patrepeval huggingface dataset:
Human fertilin β: Identification, characterization, and chromosomal mapping of an ADAM gene family member (1997)

Fertilin alpha/beta (PH30 alpha/beta) is a heterodimeric sperm surface protein containing binding and fusion domains with potential for interaction with integrin receptors on the oocyte. We report the cDNA cloning, deduced amino acid sequence, tissue specificity, and chromosomal mapping of human fertilin beta. Encoded by a 2205 nucleotide open reading frame, the deduced amino acid sequence of human fertilin beta contains pro-, metalloprotease-like, disintegrin-like, cysteine-rich, epidermal growth factor-like (EGF) repeat, transmembrane, and cytoplasmic domains. Due to this domain organization, human fertilin beta has been identified as a member of the ADAM family, which is composed of membrane-anchored proteins having A Disintegrin And Metalloprotease domain. The amino acid sequence of human fertilin beta shares 90%, 56%, and 55% identity, respectively, to monkey, guinea pig, and mouse fertilin beta homologs. A phenylalanine-glutamate-glutamate (FEE) binding tripeptide within the disintegrin-like domain of human fertilin beta, homologous to other fertilin beta RGD-like (arginine-glycine-aspartic acid) tripeptides, could compete for recognition by integrins and other receptors. Northern analysis from 16 human tissues revealed human fertilin beta's 2.9 kb message only in testis, which raises interest in possible clinical applications of this molecule as a contraceptive vaccinogen. Human fertilin beta maps to chromosome 8, band p11.2, by fluorescence in situ hybridization and mouse/human somatic cell hybrid Southern hybridization.
Q FEVER IN LAUNDRY WORKERS, PRESUMABLY TRANSMITTED FROM CONTAMINATED CLOTHING1 (1949)

Journal Article Q FEVER IN LAUNDRY WORKERS, PRESUMABLY TRANSMITTED FROM CONTAMINATED CLOTHING Get access JOHN W. OLIPHANT, JOHN W. OLIPHANT Search for other works by this author on: Oxford Academic PubMed Google Scholar DONALD A. GORDON, DONALD A. GORDON Search for other works by this author on: Oxford Academic PubMed Google Scholar ARMON MEIS, ARMON MEIS Search for other works by this author on: Oxford Academic PubMed Google Scholar R. R. PARKER R. R. PARKER Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 49, Issue 1, January 1949, Pages 76–82, https://doi.org/10.1093/oxfordjournals.aje.a119261 Published: 01 January 1949 Article history Received: 19 October 1948 Published: 01 January 1949
Gender Differences in Macrophage Antiviral Function following Exercise Stress (2006)

These data suggest that altered macrophage antiviral resistance to HSV-1 may contribute to gender differences in in vivo resistance to HSV-1 respiratory infection at rest, as well as following moderate and exhaustive exercise.
Learning visual models from shape contours using multiscale convex/concave structure matching (1993)

A novel approach is proposed for learning a visual model from real shape samples of the same class. The approach can directly acquire a visual model by generalizing the multiscale convex/concave structure of a class of shapes, that is, the approach is based on the concept that shape generalization is shape simplification wherein perceptually relevant features are retained. The simplification does not mean the approximation of shapes but rather the extraction of the optimum scale convex/concave structure common to shape samples of the class. The common structure is obtained by applying the multiscale convex/concave structure-matching method to all shape pairs among given shape samples of the class and by integrating the matching results. The matching method, is applicable to heavily deformed shapes and is effectively implemented with dynamic programming techniques. The approach can acquire a visual model from a few samples without any a priori knowledge of the class. The obtained model is very useful for shape recognition. Results of applying the proposed method are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Monitoring Stream Properties for Continuous Query Processing (2003)

focus now on properties related to stream data and arrival characteristics. As a simple example of property-based query execution, if a stream is known to be roughly sorted on an attribute , and is a join attribute or is the grouping attribute in an aggregate query, much less memory is required than for a plan that accommodates randomly arriving values of . More subtly, the best plan for an -way sliding-window stream join depends heavily on the relative arrival rates of the streams involved in the join [VNB02], and &quot;traditional&quot; data statistics such as histograms, but over recent stream elements [DGIM02]. Scheduling decisions depend on stream burstiness and data characteristics [BBDM03]. In [BW02] we studied three specific stream properties and how they affect query execution: sortedness, clustering, and stream-based referential integrity. We identified an adherence parameter for each type of constraint, which indicates how closely a stream (or pair of streams, for r
A Novel Copper Layer-Based Field-to-Trace Coupling Model and EMS Evaluation Method for DSP-Based Control Circuit in MMC-HVDC System (2019)

Underlying control circuit failure problems, especially control signal output failure problems, widely occur in high-voltage large-current modular multilevel converter (MMC) valve towers. The failure mechanism for the digital signal processor (DSP)-based control circuit is studied in this article. This study is based on the combination of low-voltage-level integrated circuit (IC) immunity model and a new perspective on the field-to-trace coupling effect. A novel copper-layer-based field-to-trace coupling model which combines the power system and digital control circuit in the MMC valve tower is proposed. Therefore, the specific electromagnetic interference (EMI) value conducted into the IC can be calculated. Then a new DSP IC electromagnetic sensitivity (EMS) evaluation method is proposed, which can be a guideline in industrial applications. To show the validity and accuracy of the field-to-trace coupling model, an indirect laboratory experiment is designed, then a situation is considered in this article, and the results are compared with PSpice circuit simulations, which show acceptable relative errors. Moreover, based on the situation considered above, one application example of the novel evaluation method is described in detail.
Comprehensive LC−MS<sup>E</sup> Lipidomic Analysis using a Shotgun Approach and Its Application to Biomarker Detection and Identification in Osteoarthritis Patients (2010)

A fast and robust method for lipid profiling utilizing liquid chromatography coupled with mass spectrometry has been demonstrated and validated for the analysis of human plasma. This method allowed quantification and identification of lipids in human plasma using parallel alternating low energy and high energy collision spectral acquisition modes. A total of 275 [corrected] lipids were identified and quantified (as relative concentrations) in both positive and negative ion electrospray ionization mode. The method was validated with five nonendogenous lipids, and the linearity (r(2) better than 0.994) and the intraday and interday repeatability (relative standard deviation, 4-6% and 5-8%, respectively) were satisfactory. The developed lipid profiling method was successfully applied for the analysis of plasma from osteoarthritis (OA) patients. The multivariate statistical analysis by partial least-squares-discrimination analysis suggested an altered lipid metabolism associated with osteoarthritis and the release of arachidonic acid from phospholipids.
A predictive controller for the Mach number in a transonic wind tunnel (1991)

The use of the unified predictive controller in controlling the Mach number of a transonic wind tunnel is examined. It is shown, by means of simulations and experiments, that the unified predictive controller yields an overall performance improvement of 30-60% in comparison with the proportional-integral-derivative (PID) controller that is normally used to control the Mach number. The rejection by the unified predictive controller of disturbances caused by changing the angle of attack is a factor of four better than that for the PID controller. This makes it possible to change the angle of attack faster, so that the efficiency of the wind tunnel operation can be improved. It is believed that this is mainly due to the fact that knowledge about the disturbances can be incorporated into the predictive controller design. Simulations have shown that even better results can be expected; the results have not yet been verified by experiments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Effect of Growth Hormone on the Insulin-Like Growth Factor System during Fasting (2003)

The present study investigates the possible stimulatory effect of endogenous GH on IGF and IGF-binding protein (IGFBP) levels during fasting. Eight normal subjects were examined on four occasions: 1) in the basal postabsorptive state; 2) after 40 h of fasting; 3) after 40 h of fasting with somatostatin suppression of GH; and 4) after 40 h of fasting with suppression of GH and exogenous GH replacement. The two somatostatin experiments were identical in terms of hormone replacement (except for GH). Short-term fasting led to a 50% reduction in free IGF-I. The reduction in free IGF-I was paralleled by an increase in IGFBP-1, an increase in the complex formation of IGFBP-1 and IGF-I, and a modest reduction in IGFBP-3 proteolysis. GH deprivation during fasting led to a 35% reduction in total IGF-I and a 70% reduction in free IGF-I. GH replacement increased free and total IGF-I to levels similar to those observed during plain fasting and decreased IGFBP-1, however, without affecting IGFBP-1-bound IGF-I. Finally, IGFBP-3 proteolysis was slightly increased by GH replacement. In conclusion, the major new finding of the present study is that the GH hypersecretion seen during short-term fasting is not merely secondary to a reduction in IGF bioactivity.
The NMDA-receptor antagonist CPP abolishes neurogenic ‘wind-up pain’ after intrathecal administration in humans (1992)

Involvement of the NMDA receptor system in the transmission of nociceptive information, including the development of central sensitization and a wind-up phenomenon, has increased interest in NMDA-receptor antagonists as antinociceptive drugs. This case report describes the use of an NMDA receptor antagonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) in a carefully selected patient with severe and intractable neurogenic pain in her left leg. The pain syndrome had components of a continuous deep pain, an allodynia, and a wind-up-like component, including afterdischarge and spread of painful sensations outside the territory of the injured nerve. After intrathecal (i.t.) administration of 200 nmol of CPP the continuous deep pain component and allodynia were unchanged, but the following 'wind-up' phenomenon with afterdischarge and spread of the pain sensation in the left half of the body was completely abolished. Another 500 nmol of CPP administered over 2 h did not improve pain relief. Pain thresholds for heat and cold stimulation, measured with a Marstock thermostimulator, did not change. There was no effect on blood pressure, heart rate, sensitivity, reflexes, coordination or motor performance. Psychotomimetic ketamine-like side effects developed 4 h after the last injection of CPP and were probably due to rostral spread of CPP. These early experiences with i.t. administration of NMDA-receptor antagonists to humans indicate that the NMDA-receptor system plays an important role in neurogenic pain and that antagonizing this system may be a useful way to obtain better pain control although psychotomimetic side effects due to rostral spread may be a problem.
Evaluation of the Rabbit Nasal Cavity in Inhalation Studies and a Comparison with Other Common Laboratory Species and Man (2011)

The rabbit is occasionally used for inhalation and intranasal safety assessment studies, but there are no detailed descriptions of the anatomy or histology of the rabbit nose. To address this deficit, the nasal cavities of thirty-two control adult rabbits were sectioned and examined to provide mapping of the main epithelial types and histological structures present within the cavity and turbinates. Four levels of the nasal cavity were prepared and examined using anatomic landmarks. Level I was sectioned immediately posterior to the incisors, Level II at the first palatal ridge, Level III immediately anterior to the first upper premolar teeth, and Level IV immediately anterior to the first upper molar. Level I was lined predominantly by squamous epithelium with small amounts of thick transitional epithelium, and examination is recommended only for studies involving test article administration via instillation. Level II was lined primarily with transitional and respiratory epithelia, whereas Levels III and IV were lined with respiratory and olfactory epithelia and often contained nasal-associated lymphoid tissue. The vomeronasal organs were evident only in Level II. The similarities and differences of these features are compared with those of other common laboratory species (rat, mouse, dog, and cynomolgus monkey) and man.
Nonhuman Primate Model of Pertussis (2012)

Pertussis is a highly contagious, acute respiratory illness caused by the bacterial pathogen Bordetella pertussis. Despite nearly universal vaccine coverage, pertussis rates in the United States have been rising steadily over the last 20 years. Our failure to comprehend and counteract this important public health concern is due in large part to gaps in our knowledge of the disease and the mechanisms of vaccine-mediated protection. Important questions about pertussis pathogenesis and mechanisms of vaccine effectiveness remain unanswered due to the lack of an animal model that replicates the full spectrum of human disease. Because current animal models do not meet these needs, we set out to develop a nonhuman primate model of pertussis. We inoculated rhesus macaques and olive baboons with wild-type B. pertussis strains and evaluated animals for clinical disease. We found that only 25% of rhesus macaques developed pertussis. In contrast, 100% of inoculated baboons developed clinical pertussis. A strong anamnestic response was observed when convalescent baboons were infected 6 months following recovery from a primary infection. Our results demonstrate that the baboon provides an excellent model of clinical pertussis that will allow researchers to investigate pertussis pathogenesis and disease progression, evaluate currently licensed vaccines, and develop improved vaccines and therapeutics.
A New Colostomy Set (1951)

Miss Tinklepaugh (Grant Hospital School of Nursing, Columbus, Ohio) is superintendent of nurses at Marion City Hospital, Marion, Ohio.
Probléma-központú tanulás (2003)

Tanulmányukban a szerzők azt vizsgálják, hogy mi jellemzi a tanulás probléma-központú felfogását, és az új médiumok mennyiben tudnak hozzájárulni a tanulási környezet átalakulásához.Arra a következtetésre jutnak, hogy az új médiumok használata az oktatásban lehetőséget ad arra, hogy az iskolában teret nyerjen a probléma-központú tanulás. A számítógépes alapú stratégiai játékok és szimulációk lehetővé teszik, hogy a problémákat valószerűen, különböző kontextusokban, más-más nézőpontokból tudjuk tovább gondolni, az interneten történő adatgyűjtés pedig az önálló tanulás és a kritikai szemlélet új lehetőségeit és kihívásait rejti magában, egyedül a számítógépre alapozva azonban nem volna ésszerű alapvető változásokat várni az iskolai tanulásban. A cikk második része ismerteti a hesseni SEMIK programot és több más németországi kezdeményezést a számítógépek és az internet újszerű, interaktív alkalmazására a problémaközpontú oktatásban, rámutatva bizonyos nehézségekre és akadályokra is.
Stimuli-responsive hierarchically self-assembled 3D porous polymer-based structures with aligned pores (2012)

We have developed a novel approach for the fabrication of self-assembled porous materials with uniaxial tubular pores. The approach is based on the use of microtubes formed by stimuli-induced rolling of polymer bilayers consisting of hydrophobic and stimuli-responsive hydrophilic polymers. Different objects, for example yeast cells, can be encapsulated inside the tubes during their rolling. The self-rolled tubes filled with the yeast cells are capable of controlled self-assembly and form a uniaxial tubular homogeneously filled scaffold. Moreover, our approach allows design of porous materials with the pores having different properties.
Piperonylic acid stimulates keratinocyte growth and survival by activating epidermal growth factor receptor (EGFR) (2018)

Epidermal growth factor (EGF) stimulates cell growth, proliferation, and survival. The biological benefits of EGF have been utilized in medical uses for improving wound healing as well as in today's skin cosmetics. EGF has been found in urine, saliva, milk, and plasma, but its efficient isolation remains a difficult task. With technical advances, recombinant protein purification technique has been used for EGF production. However, the recombinant EGF is still expensive and keeping it with stable activity is difficult to be used widely. Thus, a molecule that can mimic the EGF activity would be a useful alternative of EGF. Herein, we have discovered that a natural small molecule piperonylic acid shows EGF-like activity in HaCaT keratinocytes. Piperonylic acid induced EGF receptor (EGFR) activation and resulted in serial activation of the downstream modulators. The activated signaling pathway eventually up-regulated gene expression of egr-1, c-fos, c-jun, and c-myc, which are involved in cell growth and survival. Moreover, piperonylic acid showed promoting role in keratinocyte growth and survival from UVB-induced cellular damages. This study has revealed the EGF-like activity of piperonylic acid and proposed that the piperonylic acid could be a promising component for skin wound healing agents or cosmetic ingredient.
Cross-cultural considerations in community psychiatry. (1975)

With the advent of community psychiatry it has become imperative to reconsider the role and meaning of such basic concepts as ego development, oedipal conflicts, object relations, etc. So much of life in the ghetto has been reduced merely to the struggle for survival. This is even more dramatically evident in dealing with the emotional and behavioral problems encountered among the children. Psychological intervention in any dimension must recognize and adapt or redefine these concepts within the context of the particular cultural and social environment. This varies widely when dominated by violence, disruption, and chaotic life experiences. Cases are cited to demonstrate the problems facing the practitioner who must attempt to treat a host of multi-faceted problem areas.
Exploiting plant virus‐derived components to achieve <i>in planta</i> expression and for templates for synthetic biology applications (2013)

This review discusses the varying roles that have been played by many plant-viral regulatory sequences and proteins in the creation of plant-based expression systems and virus particles for use in nanotechnology. Essentially, there are two ways of expressing an exogenous protein: the creation of transgenic plants possessing a stably integrated gene construction, or the transient expression of the desired gene following the infiltration of the gene construct. Both depend on disarmed strains of Agrobacterium tumefaciens to deliver the created gene construction into cell nuclei, usually through the deployment of virus-derived components. The importance of efficient mRNA translation in the latter process is highlighted. Plant viruses replicate to sustain an infection to promote their survival. The major product of this, the virus particle, is finding increasing roles in the emerging field of bionanotechnology. One of the major products of plant-viral expression is the virus-like particle (VLP). These are increasingly playing a role in vaccine development. Similarly, many VLPs are suitable for the investigation of the many facets of the emerging field of synthetic biology, which encompasses the design and construction of new biological functions and systems not found in nature. Genetic and chemical modifications to plant-generated VLPs serve as ideal starter templates for many downstream synthetic biology applications.
Comparative integromics on BMP/GDF family (2006)

WNT, Notch, FGF, Hedgehog and BMP signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMP10, BMP15, AMH, GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, GDF8, GDF9, GDF10, GDF11, and GDF15 are BMP/GDF family genes within the human genome; however, transcriptional regulation of BMP/GDF family members by the canonical WNT signaling pathway remains unclear. We searched for the TCF/LEF-binding site within the promoter region of BMP/GDF family genes by using bioinformatics and human intelligence. Because four TCF/LEF-binding sites were identified within human GDF10 promoter, comparative genomics analyses on GDF10 orthologs were further performed. Chimpanzee GDF10 gene, encoding a 477-amino-acid protein, was identified within NW_112875.1 genome sequence. AY412135.1 was not the correct coding sequence for chimpanzee GDF10. Chimpanzee GDF10 showed 99.2%, 83.2% and 47.4% total amino-acid identity with human GDF10, mouse Gdf10 and human BMP3, respectively. RASGEF1A-GDF10-PRKG1 locus at human chromosome 10q11 and BMP3-PRKG2-RASGEF1B locus at human chromosome 4q21 were paralogous regions with insertions/deletions and recombination. Human GDF10 mRNA was expressed in fetal cochlea, fetal lung, testis, retina, pineal gland, other neural tissues, head and neck tumors, while mouse Gdf10 mRNA was expressed in fetal liver, inner ear, cerebellum, other neural tissues, prostate and blood vessels. Four TCF/LEF-binding sites in human GDF10 promoter were conserved in chimpanzee GDF10 promoter, but not in the mouse Gdf10 promoter; however, another TCF/LEF-binding site occurred in mouse Gdf10 promoter. Four bHLH-binding sites in human GDF10 promoter were conserved in chimpanzee GDF10 promoter, but only one in mouse Gdf10 promoter. Primate GDF10 promoters were divergent from mouse Gdf10 promoter. Because GDF10 was characterized as a potential target of canonical WNT signaling pathway in neural tissues, GDF10 is one of the targets of systems medicine, especially in the field of regenerative medicine.
Fascian<sup>®</sup> (2004)

Fascian is preserved particulate fascia derived from the gastrocnemious fascia that extends from the Achilles tendon. Over 50,000 syringes of material have been sold to physicians over the past six years with an impeccable safety record. The material has been used for wrinkles, scars, fat atrophy, diffuse depressions, paralyzed lips and tongues, nasolabial folds, cellulite, and other problems. Solid fascia grafts are routinely replaced with native collagen and a similar effect may be achieved with Fascian, especially after repeat injections. The FDA classifies the material as a tissue product, so injections may be made anywhere in the human body at the physician's discretion. Injections may last from a few months to permanently, depending on the volume of material, location, particle size, skin layer, and technique.