gebhart/patrepeval huggingface dataset:
IO Tetris: Deep Storage Consolidation for the Cloud via Fine-Grained Workload Analysis (2011)

Intelligent workload consolidation in storage systems leads to better Return On Investment (ROI), in terms of more efficient use of data center resources, better Quality of Service (QoS), and lower power consumption. This is particularly significant yet challenging in a cloud environment, in which a large set of different workloads multiplex on a shared, heterogeneous infrastructure. However, the increasing availability of fine grained workload logging facilities allows better insights to be gained from workload profiles. As a consequence, consolidation can be done more deeply, according to a detailed understanding of how well given workloads mix. We describe IO Tetris, which takes a first look at fine-grained consolidation in large-scale storage systems by leveraging temporal patterns found in real-world I/O traces gathered from enterprise storage environments. The core functionality of IO Tetris consists of two stages. A grouping stage performs hierarchical grouping of storage workloads to find complementary groupings that consolidate well together over time and conflicting ones that do not. After that, a migration stage examines the discovered groupings to determine how to maximize resource utilization efficiency while minimizing migration costs. Experiments based on customer I/O traces from a high-end enterprise class IBM storage controller show that a non-trivial number of IO Tetris groupings exist in real-world storage workloads, and that these groupings can be leveraged to achieve better storage consolidation in a cloud setting.
The role of TIMPs in regulation of extracellular matrix proteolysis (2015)

Tissue inhibitors of metalloproteinases (TIMPs), which inhibit matrix metalloproteinases (MMPs) as well as the closely related, a disintegrin and metalloproteinases (ADAMs) and ADAMs with thrombospondin motifs (ADAMTSs), were traditionally thought to control extracellular matrix (ECM) proteolysis through direct inhibition of MMP-dependent ECM proteolysis. This classical role for TIMPs suggests that increased TIMP levels results in ECM accumulation (or fibrosis), whereas loss of TIMPs leads to enhanced matrix proteolysis. Mice lacking TIMP family members have provided support for such a role; however, studies with these TIMP deficient mice have also demonstrated that loss of TIMPs can often be associated with an accumulation of ECM. Collectively, these studies suggest that the divergent roles of TIMPs in matrix accumulation and proteolysis, which together can be referred to as ECM turnover, are dependent on the TIMP, specific tissue, and local tissue environment (i.e. health vs. injury/disease). Ultimately, these combined factors dictate the specific metalloproteinases being regulated by a given TIMP, and it is likely the diversity of metalloproteinases and their physiological substrates that determines whether TIMPs inhibit matrix proteolysis or accumulation. In this review, we discuss the evidence for the dichotomous roles of TIMPs in ECM turnover highlighting some of the common findings between different TIMP family members. Importantly, while we now have a better understanding of the role of TIMPs in regulating ECM turnover, much remains to be determined. Data on the specific metalloproteinases inhibited by different TIMPs in vivo remains limited and must be the focus of future studies.
Study on LCD Motion Blur Reduction Based on Blind Signal Processing (2010)

Motion blur is one of main challenges for using LCDs in television applications.An effective method for reducing the motion blur by blind signal processing was proposed.In this method,the LCD motion blur images are obtained by the MPRT(Motion Picture Response Time),and the motion vectors are estimated using the cepstral method,then the motion vectors are used in a pre-model for LCD motion blur image,and finally an initialization point spread function(PSF) of blind deconvolution can be constructed.The simulation results show that the proposed blind deconvolution can significantly reduce the visible blurring artifact on LCD.
The Effects of Extracellular Acidosis on Neurons and Glia in vitro (1989)

Cerebral lactic acid, a product of ischemic anaerobic glycolysis, may directly contribute to ischemic brain damage in vivo. In this study we evaluated the effects of extracellular acid exposure on 7-day-old cultures of embryonic rat forebrain. Mixed neuronal and glial cultures were exposed to either lactic or hydrochloric acid to compare the toxicities of relatively permeable and impermeable acids. Neurons were relatively resistant to extra-cellular HCl acidosis, often surviving 10-min exposures to pH 3.8. In the same cultures, immunochemically defined astrocytes survived 10-min HCl exposures to a maximum acidity of pH 4.2. Similarly, axonal bundles defasciculated in HCl-titrated media below pH 4.4, although their constituent fibers often survived pH 3.8. Cell death occurred at higher pH in cultures subjected to lactic acidosis than in those exposed to HCl. Over half of forebrain neurons and glia subjected for 10 min to lactic acidification failed to survive exposure to pH 4.9. Longer 1-h lactic acid incubations resulted in cell death below pH 5.2. The potent cytotoxicity of lactic acid may be a direct result of the relatively rapid transfer of its neutral protonated form across cell membranes. This process would rapidly deplete intracellular buffer stores, resulting in unchecked cytosolic acidification. Neuronal and glial death from extracellular acidosis may therefore be a function of both the degree and the rapidity of intracellular acidification.
[Neurokinin 1 receptor antagonists--between hope and disappointment]. (2006)

Substance P (SP)/Neurokinin 1 (NK1) receptor pathways have been repeatedly implicated in the pathophysiology of central, pulmonary, and gastric disorders. A large body of evidence that has been generated from animal experiments indicates that treatment with selective NK1 receptor antagonists might be effective in the treatment of certain forms of disorders, analgesia, depression, migraine, asthma, or gastrointestinal disorders. Accordingly, numerous NK1 receptor antagonists have either been synthesized and are under clinical development, or have already been tested in clinical trials. However, the initial encouraging clinical results were followed by repeated demonstration of a lack of effectiveness. Up to now, only one NK1 receptor antagonist, aprepitant, is available for therapeutical use. Aprepitant is a selective high-affinity human SP/NK1 receptor antagonist approved by the FDA in 2003. Aprepitant is indicated for prophylaxis of acute- and delayed-phase nausea and emesis caused by chemotherapy regimens. It is used in combination with a 5-hydroxytryptamine (5-HT3) antagonist and a corticosteroid. It is the first antiemetic agent that acts by binding the NK1 receptor. Research continues and novel molecules may show better pharmacokinetic and pharmacodynamic properties and, therefore, may achieve therapeutic success.
Mapping Cofilin-Actin Rods in Stressed Hippocampal Slices and the Role of cdc42 in Amyloid-β-Induced Rods (2009)

Dissociated hippocampal neurons exposed to a variety of degenerative stimuli form neuritic cofilin-actin rods. Here we report on stimulus driven regional rod formation in organotypic hippocampal slices. Ultrastructural analysis of rods formed in slices demonstrates mitochondria and vesicles become entrapped within some rods. We developed a template for combining and mapping data from multiple slices, enabling statistical analysis for the identification of vulnerable sub-regions. Amyloid-beta (Abeta) induces rods predominantly in the dentate gyrus region, and Abeta-induced rods are reversible following washout. Rods that persist 24 h following transient (30 min) ATP-depletion are broadly distributed, whereas rods formed in response to excitotoxic glutamate localize within and nearby the pyramidal neurons. Time-lapse imaging of cofilin-GFP-expressing neurons within slices shows neuronal rod formation begins rapidly and peaks by 10 min of anoxia. In approximately 50% of responding neurons, Abeta-induced rod formation acts via cdc42, an upstream regulator of cofilin. These new observations support a role for cofilin-actin rods in stress-induced disruption of cargo transport and synaptic function within hippocampal neurons and suggest both cdc42-dependent and independent pathways modulate cofilin activity downstream from Abeta.
High-repetition-rate 2.70 and 2.79 /spl mu/m ErCr:YSGG lasers (1998)

Summary form only given. We report on flashlamp-pumped high-power laser operation of Er/sup 3+/Cr:YSGG in the mid-IR at high repetition rates of up to 75 Hz in the free running and Q-switched regime. Flashlamp pumping has been performed in a single lamp silver plated elliptical reflector. Thus the pump light is focused towards the center of the laser rod resulting in a pump profile giving better coincidence between mode and pump volume. This is essential for laser operation at high repetition rates due to the occurring strong thermal side effects, e.g. lensing or birefringence. Although the pulse repetition frequency is high the pump power could be held below 600 W.
CW CARBON MONOXIDE LASER WITH MICROWAVE EXCITATION IN THE SUPERSONIC FLOW (1980)

A new technique of efficiently coupling microwave energy into a supersonic gas flow is described. The stable self-sustained microwave discharge is applied to excite a cw CO gasdynamic laser. Electron densities well above the cut-off value have been achieved together with a reduced field strength within the discharge that is appropriate for efficient vibrational excitation. With an energy loading of 0.15 eV/CO a laser power of 340 Watts is obtained at an overall efficiency of 7 %. The effect of some additives on stability and laser performance is studied.
The efficiency of microbial protein synthesis in the rumen and the degradability of feed nitrogen between the mouth and abomasum in steers given different diets (1984)

Protozoa-free steers with simple rumen and abomasal cannulas were given basal diets consisting of a concentrate mixture of flaked maize and tapioca with barley straw (BS) or alkali-treated barley straw (BSA). Other diets were supplemented with urea (BSU and BSAU respectively) or with fish meal replacing the tapioca (BSF and BSAF respectively). The diets were isoenergetic and calculated to provide sufficient metabolizable energy (ME) to support a growth rate of 0.5 kg/d. Rumen-degradable nitrogen (RDN):ME values (g/MJ) were estimated to be 0.50, 1.20 and 0.80 for the basal diet, urea- and fish-meal-supplemented diets respectively. RNA and alpha,epsilon-diaminopimelic acid (DAP) were used as microbial markers. 103Ruthenium and polyethylene glycol (PEG) were given as flow markers and flows (g/24 h) at the abomasum of organic matter (OM) and nitrogenous constituents were calculated. Samples of mixed bacteria separated from rumen digesta from animals receiving N-supplemented diets contained significantly more N than those from animals receiving basal diets (approximately 74 and 62 mg/g dry matter (DM) respectively) but there were no other significant differences in total-N contents between treatments. RNA-N:total-N values were similar for all diets (approximately 0.13). DAP-N:total-N values were significantly lower in bacteria from animals receiving alkali-treated (AT) rather than untreated (UT) straw (approximately 0.008 and 0.011 respectively). The proportion of OM intake digested in the rumen (ADOM) was significantly higher for animals receiving AT straw rather than UT straw (approximately 0.54 and 0.43 respectively). N supplementation had no effect on OM digestibility.(ABSTRACT TRUNCATED AT 250 WORDS)
Nicotinic Acid: A Review of Its Clinical Use in the Treatment of Lipid Disorders (1988)

Nicotinic acid (niacin) is a water-soluble vitamin widely used for the treatment of lipid disorders. In pharmacologic doses (1 g or more/day), alone or in combination with other lipid-lowering drugs, nicotinic acid lowers very low-density (VLDL) and low-density lipoprotein (LDL) levels, while concurrently increasing high-density lipoprotein (HDL) levels. It may reduce long-term mortality in patients with known coronary artery disease and may slow or reverse the progression of atherosclerosis. A major consideration against using nicotinic acid is the occurrence of frequent, bothersome, adverse reactions such as cutaneous flushing, skin rash, and gastric upset. Careful dosing titration may, however, minimize these effects. The beneficial effects, taken together with the low cost of nicotinic acid therapy and the relative freedom from serious side effects, have made nicotinic acid the agent of choice for the treatment of many patients with hyperlipidemia.
Low level recognition of human motion (or how to get your man without finding his body parts) (2002)

The recognition of human movements such as walking, running or climbing has been approached previously by tracking a number of feature points and either classifying the trajectories directly or matching them with a high-level model of the movement. A major difficulty with these methods is acquiring and trading the requisite feature points, which are generally specific joints such as knees or angles. This requires previous recognition and/or part segmentation of the actor. We show that the recognition of walking or any repetitive motion activity can be accomplished on the basis of bottom up processing, which does not require the prior identification of specific parts, or classification of the actor. In particular, we demonstrate that repetitive motion is such a strong cue, that the moving actor can be segmented, normalized spatially and temporally, and recognized by matching against a spatiotemporal template of motion features. We have implemented a real-time system that can recognize and classify repetitive motion activities in normal gray-scale image sequences.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Double-Strand DNA-Templated Formation of Copper Nanoparticles as Fluorescent Probe for Label-Free Aptamer Sensor (2011)

Double-strand DNA (dsDNA) can act as an efficient template for the formation of copper nanoparticles (Cu NPs) at low concentration of CuSO(4), and the formed Cu NPs have excellent fluorescence, whereas a single-strand DNA (ssDNA) template does not support Cu NPs' formation. This property of dsDNA-Cu NPs makes it suitable for DNA sensing. However, exploration of dsDNA-Cu NPs applied in biological analysis is still at an early stage. In this regard, we report herein for the first time a sensitive, cost-effective, and simple aptamer sensor (aptasensor) using dsDNA-Cu NPs as fluorescent probe. The design consists of a dsDNA with reporter DNA (here, aptamer) as template for the formation of Cu NPs, and the formed dsDNA-Cu NPs show high fluorescence. Using adenosine triphosphate (ATP) as a model analyte, the introduction of ATP triggers the structure switching of reporter DNA to form aptamer-ATP complex, causing the destruction of the double helix and thus no formation of the Cu NPs, resulting in low fluorescence. The preferable linear range (0.05-500 μM), sensitivity (LOD 28 nM), and simplicity for the detection of ATP indicate that dsDNA-Cu NPs may have great prospects in the field of biological analysis. We also use this novel fluorescent probe to determine ATP in 1% human serum and human adenocarcinoma HeLa cells. The dsDNA-Cu NPs probes provide recovery of 104-108% in 1% human serum and a prominent fluorescent signal is obtained in cellular ATP assay, revealing the practicality of using dsDNA-Cu NPs for the determination of ATP in real samples. Besides, this design is simply based on nucleic acid hybridization, so it can be generally applied to other aptamers for label-free detection of a broad range of analytes. Successful detection of cocaine with detection limit of 0.1 μM demonstrates its potential to be a general method.
Nutrients affecting brain composition and behavior. (1987)

This review examines the changes in brain composition and in various brain functions, including behavior, that can follow the ingestion of particular foods or nutrients. It details those that are best understood: the increases in serotonin, catecholamine, or acetylcholine synthesis that can occur subsequent to food-induced increases in brain levels of tryptophan, tyrosine, or choline; it also discusses the various processes that must intervene between the mouth and the synapse, so to speak, in order for a nutrient to affect neurotransmission, and it speculates as to additional brain chemicals that may ultimately be found to be affected by changes in the availability of their nutrient precursors. Because the brain chemicals best known to be nutrient dependent overlap with those thought to underlie the actions of most of the drugs used to treat psychiatric diseases, knowledge of this dependence may help the psychiatrist to understand some of the pathologic processes occurring in his/her patients, particularly those with appetitive symptoms. At the very least, such knowledge should provide the psychiatrist with objective criteria for judging when to take seriously assertions that particular foods or nutrients do indeed affect behavior (e.g., in hyperactive children). If the food can be shown to alter neurotransmitter release, it may be behaviorally-active; however, if it lacks a discernible neurochemical effect, the likelihood that it really alters behavior is small.
Path planning on a compressed terrain (2008)

We present a better algorithm for path planning on complex terrain in the presence of observers and define several metrics related to path planning to evaluate the quality of various terrain compression strategies.
The Effectiveness of Checklists versus Bar-codes towards Detecting Medication Planning and Execution Errors (2012)

The primary objective of this research was to evaluate the effectiveness of a checklist, compared to a smart pump and bar-code verification system, at detecting different categories of errors in intravenous medication administration. To address this objective, a medication administration safety checklist was first developed in an iterative user-centered design process. The resulting checklist design was then used in a high-fidelity simulation experiment comparing the effectiveness of interventions towards two classifications of error: execution and planning errors. Results showed the checklist provided no additional benefit for error detection over the control condition of current nursing practice. Relative to the checklist group, the smart pump and bar-coding intervention demonstrated increased effectiveness at detecting planning errors. Results of this work will this work will help guide the selection, implementation and design of appropriate interventions for error mitigation in medication administration.
Distinction between ‘A’-esterases and arylesterases. Implications for esterase classification (1987)

'A'-esterase activities (substrates paraoxon and pirimiphos-methyloxon) and arylesterase activities (substrate phenyl acetate) were assayed in the sera of 14 species of birds representing seven different orders and 11 species of mammal representing five different orders. Ten species of birds had no detectable 'A'-esterase, and the remaining four species only low activity, yet all birds showed considerable arylesterase activity (16.8-99.3 mumol/min per ml of serum). Ten species of mammal showed both 'A'- and 'aryl'-esterase activities. In humans, gel filtration of serum completely separated peaks representing paraoxonase and arylesterase activities. Thus, in both birds and humans, serum enzymes exist that express arylesterase activity but not 'A'-esterase activity. These findings suggest that a distinction should be made between these two types of esterase in future classifications.
Properties and structure of Al-Zr-Fe-Si alloy after thermomechanical treatment (2018)

The effect of thermomechanical treatment on the properties and microstructure of the Al–0.3% Zr–1% Fe– 0.25% Si alloy was studied. The hot rolled samples were subjected to annealing at various temperatures in the range from 250 to 500°C. Characterization of the deformed and reversion annealed microstructures was performed by electron back scattered diffraction (EBSD), scanning electron microscope (SEM), light and transmission electron microscopy (TEM). The Vickers microhardness, tensile properties and electroconductivity of samples annealed at different temperatures were also determined. Optimum properties were observed after annealing at 400°C for 3 hours as a result of the formation of nanosized coherent dispersoids of Al3Zr (L12).
Estimating Regions of Existence of Unstable Periodic Orbits Using Computer-Based Techniques (1983)

In this paper, we present a systematic way of proving the existence of periodic solutions to a dynamical system using numerical techniques. In particular, we consider an n-dimensional ordinary differential equation, periodic in time, and state necessary conditions to prove the existence of both stable and unstable periodic solutions with the use of ordinary differential equation solvers (implemented by computer) and a knowledge of their error bounds. The method used is based on a simple shooting method and is an alternative to the Kantorovich theorem. A particularly difficult problem is considered in which the Lipschitz constant is large along unstable solutions. This leads to a modified scheme incorporating a multipoint shooting method to prove the existence of periodic solutions. The multipoint shooting method is then applied to a model in epidemiology to estimate a region of existence of an unstable periodic solution.
Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling (2015)

Initial and recurrent stroke produces central nervous system (CNS) damage, involving neuroinflammation. Receptor-mediated S1P signaling can influence neuroinflammation and has been implicated in cerebral ischemia through effects on the immune system. However, S1P-mediated events also occur within the brain itself where its roles during stroke have been less well studied. Here we investigated the involvement of S1P signaling in initial and recurrent stroke by using a transient middle cerebral artery occlusion/reperfusion (M/R) model combined with analyses of S1P signaling. Gene expression for S1P receptors and involved enzymes was altered during M/R, supporting changes in S1P signaling. Direct S1P microinjection into the normal CNS induced neuroglial activation, implicating S1P-initiated neuroinflammatory responses that resembled CNS changes seen during initial M/R challenge. Moreover, S1P microinjection combined with M/R potentiated brain damage, approximating a model for recurrent stroke dependent on S1P and suggesting that reduction in S1P signaling could ameliorate stroke damage. Delivery of FTY720 that removes S1P signaling with chronic exposure reduced damage in both initial and S1P-potentiated M/R-challenged brain, while reducing stroke markers like TNF-α. These results implicate direct S1P CNS signaling in the etiology of initial and recurrent stroke that can be therapeutically accessed by S1P modulators acting within the brain.