gebhart/patrepeval huggingface dataset:
Immunopharmacology and pathophysiology (1992)

Pharmacology of Endotoxins: Cyclic Nucleotides and Lipopolysaccharide Action (R.G. Coffey and J.W. Hadden). Endotoxin-Induced Oxidative Metabolism of Unsaturated Fatty Acids (F.U. Schade, R. Engel, D. Jakobs, and T. Kirikae). Interactions between Platelet-Activating Factor and Lipopolysaccharide: Consequences in Endotoxemia and Sepsis (D. Hosford and P. Braquet). Tumor Necrosis Factor and Host Response to Endotoxin (C. Galanos, M.A. Freudenberg, T. Katschinski, R. Salomao, H. Mossmann, and Y. Kumazawa). Role of Interleukin 1 in Systemic Responses to LPS (C.A. Dinarello). Interleukin 6 and LPS Host Response (R.E. McCallum and M.R. Hill). Lipopolysaccharide-Induced Interferon (S.N. Vogel). Novel Lipopolysaccharide-Induced Cytokines (S.J.H. van Deventer and A. Cerami). Interactions of LPS with Serum Complement (S.W. Vukajlovich). Immunopathophysiology of Endotoxins: Studies of the Natural History and Mechanism of the Primate (Baboon) Response to Escherichia Coli (F.B. Taylor, Jr.). Metabolism of LPS In Vivo (M.A. Freudenberg and C. Galanos). The Endocrine Response to Endotoxin (R. Silverstein). Endotoxin and Cytokine Responses in Human Volunteers (J.G. Cannon). Endotoxin and Meningococcemia: Intravascular Inflammation Induced by Native Endotoxin in Man (P. Brandtzaeg and P. Kierulf). Specificity and Function of Lipopolysaccharide Antibodies (M. Pollack). The Protective Role of Antibodies to the Lipopolysaccharide Core Region (B.J. Appelmelk and J. Cohen). Monophosphoryl Lipid A and Immunotherapy (K.B. Von Eschen). Lipid A and Liposomes Containing Lipid A as Adjuvants for Vaccines (C.R. Alving). Index.
Functional systems with orthogonal dynamic covalent bonds (2013)

This review summarizes the use of orthogonal dynamic covalent bonds to build functional systems. Dynamic covalent bonds are unique because of their dual nature. They can be as labile as non-covalent interactions or as permanent as covalent bonds, depending on conditions. Examples from nature, reaching from the role of disulfides in protein folding to thioester exchange in polyketide biosynthesis, indicate how dynamic covalent bonds are best used in functional systems. Several synthetic functional systems that employ a single type of dynamic covalent bonds have been reported. Considering that most functional systems make simultaneous use of several types of non-covalent interactions together, one would expect the literature to contain many examples in which different types of dynamic covalent bonds are similarly used in tandem. However, the incorporation of orthogonal dynamic covalent bonds into functional systems is a surprisingly rare and recent development. This review summarizes the available material comprehensively, covering a remarkably diverse collection of functions. However, probably more revealing than the specific functions addressed is that the questions asked are consistently quite unusual, very demanding and highly original, focusing on molecular systems that can self-sort, self-heal, adapt, exchange, replicate, transcribe, or even walk and "think" (logic gates). This focus on adventurous chemistry off the beaten track supports the promise that with orthogonal dynamic covalent bonds we can ask questions that otherwise cannot be asked. The broad range of functions and concepts covered should appeal to the supramolecular organic chemist but also to the broader community.
Dengue Haemorrhagic Fever presenting as Acute Abdomen. (2011)

We describe a case of a 38 year-old Sri Lankan female who was referred to the surgeon on call with a picture of acute abdomen. She presented with a three-day history of fever, headache, abdominal pain and diarrhoea; however, the physical examination was not consistent with acute abdomen. Her platelet count was 22 ×10(9)/L. A diagnosis of dengue haemorrhagic fever (DHF) was made and dengue serology was positive. Dengue epidemics have been associated with a variety of gastrointestinal symptoms and signs, including acute abdomen. Acute abdomen in patients with DHF makes the diagnosis and management challenging.
Characterization of an Extracellular Polysaccharide Elaborated by TX-1, a New Strain of<i>Beijerinckia indica</i> (1995)

Journal Article Characterization of an Extracellular Polysaccharide Elaborated by TX-1, a New Strain of Beijerinckia indica Get access Kimiko Ohtani, Kimiko Ohtani Faculty of Human Life Science, Osaka City University, 3–3–138, Sugimoto, Sumiyoshi-ku, Osaka 558, Japan To whom all correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Syouhei Yasuda, Syouhei Yasuda Graduate School of Science and Engineering, Waseda University, Ohkubo, Shinjuku-ku, Tokyo 169, Japan Search for other works by this author on: Oxford Academic Google Scholar Osamu Hiruta, Osamu Hiruta Pharmaceutical Technology Laboratories, Meiji Seika Kaisha Ltd., 788 Kayama, Odawara-shi, Kanagawa 250, Japan Search for other works by this author on: Oxford Academic Google Scholar Kazumichi Uotani, Kazumichi Uotani Pharmaceutical Technology Laboratories, Meiji Seika Kaisha Ltd., 788 Kayama, Odawara-shi, Kanagawa 250, Japan Search for other works by this author on: Oxford Academic Google Scholar Kuniaki Tatsuta, Kuniaki Tatsuta Graduate School of Science and Engineering, Waseda University, Ohkubo, Shinjuku-ku, Tokyo 169, Japan Search for other works by this author on: Oxford Academic Google Scholar Akira Misaki Akira Misaki Faculty of Human Life Science, Osaka City University, 3–3–138, Sugimoto, Sumiyoshi-ku, Osaka 558, Japan Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 59, Issue 9, 1 January 1995, Pages 1628–1631, https://doi.org/10.1271/bbb.59.1628 Published: 01 January 1995 Article history Published: 01 January 1995 Received: 17 January 1995
Identification and purification of a novel serine proteinase inhibitor (1993)

We report the identification, purification, and partial amino acid sequence of a novel serine proteinase inhibitor which is present in extracts from human placentas and in the cytosolic fraction of the leukemic cell line K562. Extracts from these tissues exhibited time-dependent inhibition of the serine proteinase thrombin. This activity was not accelerated by heparin and corresponded to a protein which formed a 67-kDa complex with 125I-thrombin. The complex was stable on reduced sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A cleaved and functionally inactive form of the protein was purified from placental tissue by chromatography on DEAE-Sepharose, followed by affinity chromatography on thrombin-Sepharose. Antibodies raised against the placental protein recognized the inhibitor from K562 cells and placental extract. Western blotting experiments using the antibody showed that the uncleaved inhibitor has a molecular mass of 38 kDa. Amino acid sequencing was performed on the purified protein. Sequences of peptides resulting from digestion with cyanogen bromide followed by Endoproteinase Lys-c confirmed that this is a novel inhibitor with significant homology to the serpin family.
Index compression method with compressed mode Boolean operators (2002)

Summary form only given. This paper describes an algorithm which provides a high degree of compression and at the same time allows logical Boolean operations to be performed directly on the compressed representation of the index. An inverted index of English text using this technique has only 20% to 25% of the size of the original text. Since logical Boolean queries can be performed on the compressed index itself, access speed is greatly enhanced.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A New Take on Detecting Insider Threats (2016)

The threat that malicious insiders pose towards organisations is a significant problem. In this paper, we investigate the task of detecting such insiders through a novel method of modelling a user's normal behaviour in order to detect anomalies in that behaviour which may be indicative of an attack. Specifically, we make use of Hidden Markov Models to learn what constitutes normal behaviour, and then use them to detect significant deviations from that behaviour. Our results show that this approach is indeed successful at detecting insider threats, and in particular is able to accurately learn a user's behaviour. These initial tests improve on existing research and may provide a useful approach in addressing this part of the insider-threat challenge.
<b>A simple cryo‐SEM method for delicate plant tissues</b> (1996)

A simple modification to the existing preparative procedures for examining delicate plant tissues and insect–plant interactions by cryo‐SEM is described. Samples are attached to a stub with colloidal graphite, introduced into the air lock, evacuated briefly, then transferred onto the cryo‐stage of the preparation chamber where full evacuation and slow cooling take place. After sputter coating with gold, the samples are transferred onto the microscope cold stage and examined at 15 kV.
Genetics, biotechnology and breeding of maize and sorghum (1997)

The cereal genome - from rice to maize the hunt for QTLs in maize and sorghum breeding maize biotechnology - recent developments in maize transformation applications the role of environmental conditions in maize and sorghum development and breeding breeding maize for stress tolerance and low input demands.
Peptide-Modified Albumin Carrier Explored as a Novel Strategy for a Cell-Specific Delivery of Interferon Gamma To Treat Liver Fibrosis (2011)

Excessive accumulation of the extracellular matrix proteins primarily produced by activated hepatic stellate cells (HSC) leads to liver fibrosis. To date, no successful therapeutic intervention is available for the treatment of this disease. Platelet derived growth factor beta receptor (PDGFβR) is highly upregulated on disease-inducing activated HSC and thus can be used for delivery of antifibrotic drugs to increase therapeutic efficacy with reduced adverse effects. Interferon gamma (IFNγ) has been recognized as a potent antifibrotic cytokine; however, poor pharmacokinetics and side effects due to frequent administration have limited its clinical use. For HSC-specific delivery, a PDGFβR-specific drug delivery carrier (PPB-HSA) was developed by modifying albumin with PDGFβR-recognizing cyclic peptides. Subsequently, IFNγ was conjugated to PPB-HSA via bifunctional PEG linkers to synthesize PPB-HSA-PEG-IFNγ. In vitro, PPB-HSA-PEG-IFNγ retained complete biological activity similar to unmodified IFNγ and showed PDGFβR-specific binding to human HSC and primary culture-activated rat HSC. In TGFβ-stimulated mouse fibroblasts and human HSC, PPB-HSA-PEG-IFNγ induced significant reduction in crucial fibrotic parameters. In vivo, the conjugate rapidly accumulated into PDGFβR-expressing HSC in fibrotic livers and activated IFNγ-mediated pstat1α signaling pathway. Furthermore, in a CCl(4)-induced acute liver injury model in mice, treatment with HSC-targeted IFNγ strongly ameliorated hepatic fibrogenesis by inducing significant reduction (about 60%; p < 0.01) in collagen I and α-SMA expression as well as enhanced fibrolysis (increased MMP/TIMP ratio; p < 0.05) while free unmodified IFNγ was ineffective. Furthermore, in contrast to free native IFNγ, the conjugate did not induce macrophage infiltration and IL-1β expression in the liver. In conclusion, these data demonstrate the enhanced antifibrotic efficacy and reduced off-target effects of PPB-HSA-PEG-IFNγ conjugate showing the potential of cell-specific targeting of IFNγ for the treatment of liver fibrosis.
Radiant-Interchange Configuration Factors (1952)

A study is presented of the geometric configuration factors required for computing radiant heat transfer between opaque surfaces separated by a nonabsorbing medium and various methods of determining the configuration factors are discussed. Configuration-factor solutions available in the literature have been checked and the more complicated equations are presented as families of curves. Cases for point, line, and finite-area sources are worked out over a wide range of geometric proportions. These cases include several new configurations involving rectangles, triangles, and cylinders of finite length which are integrated and tabulated. An analysis is presented, in which configuration factors are employed of the radiant heat transfer to the rotor blades of a typical gas turbine under different conditions of temperature and pressure. (author)
Metabolomic Heterogeneity of Pulmonary Arterial Hypertension (2014)

Although multiple gene and protein expression have been extensively profiled in human pulmonary arterial hypertension (PAH), the mechanism for the development and progression of pulmonary hypertension remains elusive. Analysis of the global metabolomic heterogeneity within the pulmonary vascular system leads to a better understanding of disease progression. Using a combination of high-throughput liquid-and-gas-chromatography-based mass spectrometry, we showed unbiased metabolomic profiles of disrupted glycolysis, increased TCA cycle, and fatty acid metabolites with altered oxidation pathways in the human PAH lung. The results suggest that PAH has specific metabolic pathways contributing to increased ATP synthesis for the vascular remodeling process in severe pulmonary hypertension. These identified metabolites may serve as potential biomarkers for the diagnosis of PAH. By profiling metabolomic alterations of the PAH lung, we reveal new pathogenic mechanisms of PAH, opening an avenue of exploration for therapeutics that target metabolic pathway alterations in the progression of PAH.
Supporting Capture and Access Interfaces for Informal and Opportunistic Meetings (1999)

Automated support for the capture and access of live experiences is a common theme for ubiquitous computing. For certain capture situations, such as informal or opportunistic gatherings, existing capture frameworks are inadequate for a number of reasons. They require too much time to initiate a capture session and they often are too inflexible to support unstructured and impromptu use. In this paper, we present a whiteboard capture application called DUMMBO, aimed to support opportunistic and serendipitous meeting capture. We emphasize a easy-to-initiate interface that mirrors as much as possible traditional whiteboard functionality. This is accompanied by visualization techniques for accessing captured meetings afterwards. By separating the physical interface for capture from the electronic interface for accessing captured meetings, we demonstrate how a capture and access application can be designed to better support its intended audience. Keywords Ubiquitous computing, automated capture and access
소모둠 독서 토의에서 나타나는 상호텍스트적 연결 양상 연구 (2014)

이 연구는 초.중.고 학생들의 소모둠 독서 토의에 나타나는 상호텍스트 적 연결 양상을 분석하고자 하였다. 이를 위해 독서프레젠테이션 대회에 참여한 초등학교 8팀, 중학교 8팀, 고등학교 7팀의 독서 동아리를 대상으로 두 편의 글을 읽고 이야기 나누는 모습을 녹화하고 전사하여 분석하였다. 분석 결과 학생들은 소모둠 독서 토의에서 텍스트 내용 이해와 평가를 위해 상호텍스트적 연결 양상을 보였다. 텍스트 내용 이해를 위한 상호텍스 트적 연결 양상에서는 세부 내용 이해를 위한 사례 제시, 인물 이해를 위한 비교.대조, 텍스트 내 문제 해결을 위한 방법 제시, 주어진 두 텍스트의 주제 연결 양상이 나타났다. 텍스트 평가를 위한 상호텍스트적 연결 양상은 텍스트 내용을 평가와 텍스트 표현 평가에서 나타났다. 이 결과는 읽기나 문학 수업에서 하나의 텍스트만으로 수업하기 보다는 관련 주제에 대한 다양한 텍스트를 함께 보면서 이야기할 때, 학생들의 텍스트에 대한 이해를 깊게 할 수 있음을 보여준다. 또한 상호텍스트성 관련된 연구들이 문학 텍스 트를 중심으로 연구가 되었는데, 문학과 정보 텍스트를 함께 제공했을 때에 도 다양한 상호텍스트적 연결 양상이 나타남을 알 수 있다.
An image-based visual-motion-cue for autonomous navigation (2002)

This paper presents a novel time-based visual motion cue called the Hybrid Visual Threat Cue (HVTC) that provides some measure for a change in relative range as well as absolute clearances, between a 3D surface and a moving observer. It is shown that the HVTC is a linear combination of Time-To-Contact (TTC), visual looming and the Visual Threat Cue (VTC). The visual field associated with the HVTC can be used to demarcate the regions around a moving observer into safe and danger zones of varying degree, which may be suitable for autonomous navigation tasks. The HVTC is independent of the 3D environment and needs almost no a-priori information about it. It is rotation independent, and is measured in ~time/sup -1/\ units Several approaches to extract the HVTC, are suggested. Also a practical method to extract it from a sequence of images of a 3D textured surface obtained by a visually fixating, fixed-focus monocular camera in motion is presented. This approach of extracting the HVTC is independent of the type of 3D surface texture and needs no optical flow information, 3D reconstruction, segmentation, feature tracking.
Compile-time composition of run-time data and iteration reorderings (2003)

Many important applications, such as those using sparse data structures, have memory reference patterns that are unknown at compile-time. Prior work has developed run-time reorderings of data and computation that enhance locality in such applications.This paper presents a compile-time framework that allows the explicit composition of run-time data and iteration-reordering transformations. Our framework builds on the iteration-reordering framework of Kelly and Pugh to represent the effects of a given composition. To motivate our extension, we show that new compositions of run-time reordering transformations can result in better performance on three benchmarks.We show how to express a number of run-time data and iteration-reordering transformations that focus on improving data locality. We also describe the space of possible run-time reordering transformations and how existing transformations fit within it. Since sparse tiling techniques are included in our framework, they become more generally applicable, both to a larger class of applications, and in their composition with other reordering transformations. Finally, within the presented framework data need be remapped only once at runtime for a given composition thus exhibiting one example of overhead reductions the framework can express.
P. Wang et al. 1985. Marine Micropaleontology of China. ix + 370 pp. Beijing: China Ocean Press; Berlin, Heidelberg, New York, Tokyo: Springer-Verlag. Price DM 242 (hardback). ISBN 3 540 13147 7 (hardback). (1986)

P. Wang et al. 1985. Marine Micropaleontology of China. ix + 370 pp. Beijing: China Ocean Press; Berlin, Heidelberg, New York, Tokyo: Springer-Verlag. Price DM 242 (hardback). ISBN 3 540 13147 7 (hardback). - Volume 123 Issue 5
Mask repair using layout-based pattern copy for the 65-nm node and beyond (2006)

To overcome several drawbacks of the standard pattern copy procedure used to create the repair shape(s) for a particular defect site, we have developed and implemented a layout based pattern copy method (a.k.a. "database pattern copy"). In general, pattern copy derives the repair structure by comparing a high resolution image of the defective area with the same image of a non-defective area. The repair shape is generated as the difference of these two images, and adjusted for processing purposes. As opposed to the conventional pattern copy method, which derives the reference using information taken from the mask under repair, the new method uses reference information from the <i>original mask design file</i>. As a result, it reduces the CD error of the repair, simplifies the repair process work flow, and greatly reduces the potential of operator error. We present the new method along with experimental results taken from programmed defect repair on our MeRiT MG<sup>TM</sup> production tool.
The multimodel, multilingual approach to interoperability of multidatabase systems (2002)

Overviews the architecture of a new kind of database management system (DBMS) that facilitates data sharing and resource consolidation in heterogeneous database environments without compromising the autonomy of the individual databases. The architecture of the DBMS is based on the multimodel multilingual approach.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Solvent vapor annealed block copolymer films on organosilane self-assembled monolayers (2005)

Solvent vapor annealing is shown to be a useful technique for controlling the formation of poly(isoprene-b-styrene) (PI-b-PS) block copolymer thin film nanostructures. Annealing in methyl ethyl ketone (MEK) solvent vapor yields a hexagonal-type structure (78nm repeat distance), while toluene yields a fingerprint texture. Solvent choice for spin coating dramatically changes the initial order in these films: MEK provides a useful hexagonal structure without annealing, while toluene yields a disordered nanostructure. N-octadecyltriethoxysilane is used to form a low surface energy self-assembled monolayer which effectively reduces pinning of the copolymer to the substrate, allowing the development of regions (∼1μm in diameter) with a high degree of hexagonal order. However, after several hours of annealing in MEK vapor, the copolymer ultimately dewets from the surface. Contact mode scanning probe microscopy has proven itself to be a very useful tool for imaging the nanostructures, without damaging the films. Friction mode provides high contrast images of PI-b-PS nanostructures, suggesting the lack of a wetting layer in the solvent vapor annealed films.
Effect of Hybrid Peptides of Cecropin A and Melittin in an Experimental Model of Bacterial Keratitis (1997)

Synthetic peptides, ranging from 12 to 18 residues, containing partial sequences from natural cecropin A and melittin were tested for activity in an experimental pseudomonas keratitis model in rabbits. In separate experiments, two Pseudomonas aeruginosa strains: (a) a clinical isolated strain, and (b) an American Type Culture Collection (ATCC) strain, were inoculated into the stroma of one cornea of each rabbit. Peptides were topically applied at 0.1% in phosphate-buffered saline (PBS) and compared with PBS alone and 0.3% gentamicin eye drops. Clinical evaluation, based on the McDonald-Shadduck scale, was performed during a > 48-h period after the bacterial inoculation. The peptide-treated animals showed significantly lower (p < 0.05) inflammatory signs and lower anterior-segment bacterial damage compared with PBS-treated animals, after the first 6 h. The antiinflammatory/antimicrobial activity was non significantly differnt (p > 0.05) from that in animals treated with gentamicin. We conclude that peptides keeping the sequence KWKLFKK from cecropin A and at least the sequence VLKVL from melittin show promise as novel agents in topical ocular therapy of bacterial keratitis.
PERITONEAL DIALYSIS (1959)

Complications of earlier methods of peritonea! dialysis are eliminated by a new technique of intermittent dialysis utilizing commercially prepared electrolyte solutions, special catheters, and a "closed system" of infusion and drainage. This was mechanically successful in 76 instances. Conditions treated satisfactorily included acute renal failure, barbiturate poisoning, intractable edema, hepatic coma, hypercalcemia, and chronic uremia. Although less efficient than the artificial kidney on an hourly basis, peritoneal lavage is easier to use over extended periods of time.