gebhart/patrepeval huggingface dataset:
Dok-7 Mutations Underlie a Neuromuscular Junction Synaptopathy (2006)

Congenital myasthenic syndromes (CMSs) are a group of inherited disorders of neuromuscular transmission characterized by fatigable muscle weakness. One major subgroup of patients shows a characteristic "limb girdle" pattern of muscle weakness, in which the muscles have small, simplified neuromuscular junctions but normal acetylcholine receptor and acetylcholinesterase function. We showed that recessive inheritance of mutations in Dok-7, which result in a defective structure of the neuromuscular junction, is a cause of CMS with proximal muscle weakness.
Modern Alkyne Chemistry (2014)

Introduction PART I: CATALYTIC ISOMERIZATION OF ALKYNES 1) Redox Isomerization of Propargyl Alcohols to Enones 2) Carbophilic Cycloisomerization Reactions of Enynes and Domino Processes 3) Alkyne-Alkyne Metathesis Reactions PART II: CATALYTIC CYCLOADDITION REACTIONS 4) Alkyne-Azide Reactions 5) Catalytic Cycloaddition Reactions PART III: CATALYTIC NUCLEOPHILIC ADDITIONS AND SUBSTITUTIONS 6) Catalytic Conjugate Additions of Alkynes 7) Catalytic Alkyne-Carbonyl Additions 8) Catalytic Nucleophilic Addition of Alkynes to Imines: The A3 (Aldehyde-Alkyne-Amine) Coupling 9) Sonogashira Reactions PART IV: OTHER REACTIONS 10) Catalytic Dimerization of Alkynes 11) The Oxidative Dimerization of Acetylenes and Related Reactions: Synthesis and Applications of Conjugated 1,3-Diynes 12) The Alkyne Zipper Reaction in Asymmetric Synthesis
A high throughput 2-dimensional DCT/IDCT architecture for real-time image and video system (2002)

The discrete cosine transform (DCT) has been widely used as the core of digital image and video signal compression. In this paper, we present a high throughput 8/spl times/8 2D DCT/IDCT architecture which is well suited for the application in real time image or video system. Instead of the transport RAM in the traditional architecture, an overlapped row-column operation is used that can reduce the total latency of the pipelined structure. The multiplication is accomplished by using look-up tables and a partial sum adder to reduce the area and cycle time. It possesses no matrix transposition and is suitable for VLSI implementation. We have designed a DCT/IDCT chip using this architecture via the Compass standard cell library under the TSMC 0.35 /spl mu/m 1P4M process. The chip occupies 4278.4 /spl mu/m/spl times/4278.4 /spl mu/m and consists of 119,181 transistors. The simulation results show that a clock rate of up to 100 MHz can be achieved.
No Structural Mutation in the Dopamine D2 Receptor Gene in Alcoholism or Schizophrenia (1994)

No structural coding abnormalities in the DRD2 gene are present in alcoholism or schizophrenia.
Variations of ornithine decarboxylase activity and S-adenosyl-L-methionine and 5'-methylthioadenosine contents during the development of diethylnitrosamine-induced liver hyperplastic nodules and hepatocellular carcinoma (1987)

Liver ornithine decarboxylase (ODC) activity and content of S-adenosyl-L-methionine (SAM) and its catabolite 5'-methylthioadenosine (5'-MTA) were determined in the late stages of hepatocarcinogenesis. Wistar rats received one diethylnitrosamine dose, followed by a partial hepatectomy at the midpoint of a 15-day treatment with 2-acetylaminofluorene (2-AAF), and then by an 18-week phenobarbital (PB) treatment. Thirty-eight per cent of liver was gamma-glutamyltranspeptidase (GGT)-positive and no visible nodules and hepatocellular carcinomas developed 16 weeks after starting 2-AAF feeding. Hyperplastic nodules and hepatocellular carcinomas were found on weeks 24 and 56 respectively. On weeks 24 and 56 only approximately 10% of liver was occupied by GGT-positive foci. At all times studied the foci exhibited a low labeling index (LI), and liver ODC activity was near control values. By contrast, a high ODC activity and LI and a low SAM and 5'-MTA levels were found in hyperplastic nodules and neoplasia. These tissues exhibited a high 5'-MTA phosphorylase activity. SAM administration during PB treatment, caused a 25-36% fall of GGT-positive liver and prevented the development of hyperplastic nodules and hepatocellular carcinomas. This was coupled to a sharp increase of SAM and 5'-MTA liver contents. SAM and 5'-MTA inhibited hepatocyte DNA synthesis in vitro. The addition of 5'-MTA to the reaction mixture for the ODC assay strongly inhibited ODC activity. However, the preincubation of SAM with liver homogenates or hepatocytes, used to prepare crude ODC, was necessary to inhibit ODC activity by SAM. Adenine, an inhibitor of 5'-MTA-phosphorylase, enhanced inhibition of DNA synthesis and ODC activity by SAM and 5'-MTA. Thus, during a prolonged promoting treatment a selected population of GGT-positive foci appears to acquire a stable phenotype characterized by a high DNA and polyamine synthesis. The development of nodules and carcinomas is associated with low SAM and 5'-MTA contents and high ODC activity and LI. 5'-MTA accumulation, during SAM administration, is probably responsible for the inhibition of promotion by SAM.
Vaccination with tumor cell lysate‐pulsed dendritic cells augments the effect of <i>IFN</i>‐β gene therapy for malignant glioma in an experimental mouse intracranial glioma (2004)

Interferon-beta (IFN-beta) has been used as an antitumor drug against human glioma, melanoma and medulloblastoma since the 1980s. Recently, we developed a new gene therapy using the IFN-beta gene against malignant gliomas and then began clinical trials in 2000. Since stimulation of immune system was one mechanism of antitumor effect induced by IFN-beta gene therapy, we hypothesized that combination of IFN-beta gene therapy with immunotherapy might increase its effectiveness. In the present study, we tested whether combination therapy with IFN-beta gene therapy and immunotherapy using tumor cell lysate-pulsed dendritic cells (DCs) would increase the efficacy of IFN-beta gene therapy. In an experimental mouse intracranial glioma (GL261), which cannot be cured by either IFN-beta gene therapy or DC immunotherapy alone, IFN-beta gene therapy following DC immunotherapy resulted in a significant prolongation in survival of the mice. Moreover, when this combination was performed twice, 50% of treated mice survived longer than 100 days. Considering these results, this combination therapy may be one promising candidate for glioma therapy in the near future.
Toxicity and kinetics of amitraz in dogs (1996)

Atipamezole can be administered i.m. to dogs with severe amitraz poisoning to reverse all the effects observed.
Ribosomal protein S3 (rpS3) secreted from various cancer cells is N-linked glycosylated (2016)

Ribosomal protein S3 (rpS3) is a 243 amino acid component of the 40S ribosomal small subunit. It has multiple roles in translation and extra-ribosomal functions like apoptosis and DNA repair. RpS3 is secreted only in cancer cell lines. Presently, mass spectrometry analysis revealed rpS3 to be glycosylated at the Asn165 residue. A point mutation at this residue decreased secretion of rpS3 in cancer cell lines. Secretion was also inhibited by the endoplasmic reticulum (ER)-Golgi transport inhibitor Brefeldin A and by Tunicamycin, an inhibitor of N-linked glycosylation. N-linked glycosylation of rpS3 was confirmed as necessary for rpS3 secretion into culture media via the ER-Golgi dependent pathway. RpS3 bound to Concanavalin A, a carbohydrate binding lectin protein, while treatment with peptide-N-glycosidase F shifted the secreted rpS3 to a lower molecular weight band. In addition, the N165G mutant of rpS3 displayed reduced secretion compared to the wild-type. An in vitro binding assay detected rpS3 homodimer formation via the N-terminal region (rpS3:1-85) and a middle region (rpS3:95-158). The results indicate that the Asn 165 residue of rpS3 is a critical site for N-linked glycosylation and passage through the ER-Golgi secretion pathway.
A fast and compact longest match prefix look-up method using pointer cache for very long network address (2003)

We propose a fast and compact longest match table look-up method for very long network addresses like IP version 6. This method uses two ideas for a routing-table arranged in a tree-structure. The first idea is to make table look-up fast by caching pointers to intermediate nodes in the tree, reducing the number of node traversals. The second idea is to reduce the memory size required for each node in the tree by one-third by eliminating common parts of addresses of adjacent nodes. Evaluating the performance of this method by using actual routing table data of an IP backbone network, we found it was five to ten times faster than a conventional method.
Evaluation of U.S. Plant Introductions of Watermelon for Resistance to Powdery Mildew (2005)

Two hundred sixty-six Citrullus lanatus (Thumb.) Matsum. & Nakai accessions (Plant Introductions and named cultivars) were tested against a race 2 Sphaerotheca fuliginea (Schlechtend.: Fr.) Pollacci isolate to evaluate for resistance to powdery mildew disease. Growth room-grown seedlings were artificially inoculated with conidia from watermelon host leaves at 2-day intervals from the appearance of the first true leaf until test results data were taken, when the second true leaf was fully expanded. Plants were evaluated on a 1 to 9 scale of increasing disease severity. Disease indices (DIs) were calculated as weighted averages for each entry. All genotypes with resistant plants (powdery mildew rating 1 to 3) were reevaluated in a replicated test of 3 replications of 10 plants each. Disease indices were again calculated. Twenty-two plant introductions (PIs) and one named variety displayed intermediate resistance to powdery mildew in the replicated test with DIs ranging from 5.0 to 6.0.
Prediction of mandibular movement and its center of rotation for nonsurgical correction of anterior open bite via maxillary molar intrusion (2018)

The mandible exhibited counterclockwise rotation after maxillary molar intrusion; the center of mandibular autorotation was located behind and below condylion with individual variations.
Determination of the lower limit of detection. (1989)

Journal Article Determination of the lower limit of detection. Get access D J Anderson D J Anderson Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 35, Issue 10, 1 October 1989, Pages 2152–2153, https://doi.org/10.1093/clinchem/35.10.2152 Published: 01 October 1989
Dietary Phenolic Acids of<i>Macrotyloma uniflorum</i>(Horse Gram) Protect the Rat Heart Against Isoproterenol-Induced Myocardial Infarction (2016)

The present study investigates the cardioprotective activity of the Macrotyloma uniflorum seed extract (MUSE) and its phenolic acids (p-coumaric acid and ferulic acid) in isoproterenol (ISO)-induced myocardial infarction in rats. The previously mentioned phenolic acids were isolated and quantified from MUSE by HPLC. Pretreatment of gemfibrozil (reference standard), MUSE (250 and 500 mg/kg) and the phenolic acids for 30 days to rats treated with ISO (85 mg/kg) on the last 2 days resulted in a significant attenuation of the ISO-elevated levels of serum marker enzymes (aspartate aminotransferase, lactate dehydrogenase and creatine phosphokinase MB), total cholesterol, triglycerides, uric acid, C-reactive protein and malondialdehyde and a restoration of the levels of the ISO-depleted marker enzymes, reduced glutathione and the antioxidant enzymes-superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase in heart. Restoration of the ISO-altered electrocardiogram pattern and haemodynamic parameters (left ventricular end diastolic pressure, heart rate, systolic, diastolic and mean arterial pressure) was also brought about by treatment with MUSE and the phenolic acids. It may be concluded that MUSE treatment to ISO-challenged rats exhibits a significant cardioprotective effect probably because of the potent antioxidant activity of its phenolic acids that salvage the myocardium from the deleterious effects of ISO. Copyright © 2016 John Wiley & Sons, Ltd.
Design Principles for Integration of Model-Driven Quality Assurance Tools (2011)

The engineering of software systems is supported by tools in different phases of the software development. The integration of these tools is crucial to assure the trace ability of existing models and artifacts, and to support the automation of critical software development phases such as software testing and validation. In particular, the integration of novel software quality assurance tools into existing environments must be performed in a way that minimizes its impact on existing software process, while the benefits of the tool are leveraged. This guarantees the adoption of new methodologies with minimal interference in existing production workflow. In this paper we discuss our experience in integrating a model-driven software testing tool developed within SIEMENS with a widely-adopted model-driven design tool. In particular, we establish a set of design principles from the lessons learned in this integration. We conclude showing a design that prioritizes data integration over control and presentation that achieves a high degree of tool integration while minimizing the integration development effort.
iHadoop: Asynchronous Iterations for MapReduce (2011)

MapReduce is a distributed programming framework designed to ease the development of scalable data-intensive applications for large clusters of commodity machines. Most machine learning and data mining applications involve iterative computations over large datasets, such as the Web hyperlink structures and social network graphs. Yet, the MapReduce model does not efficiently support this important class of applications. The architecture of MapReduce, most critically its dataflow techniques and task scheduling, is completely unaware of the nature of iterative applications, tasks are scheduled according to a policy that optimizes the execution for a single iteration which wastes bandwidth, I/O, and CPU cycles when compared with an optimal execution for a consecutive set of iterations. This work presents iHadoop, a modified MapReduce model, and an associated implementation, optimized for iterative computations. The iHadoop model schedules iterations asynchronously. It connects the output of one iteration to the next, allowing both to process their data concurrently. iHadoop's task scheduler exploits inter-iteration data locality by scheduling tasks that exhibit a producer/consumer relation on the same physical machine allowing a fast local data transfer. For those iterative applications that require satisfying certain criteria before termination, iHadoop runs the check concurrently during the execution of the subsequent iteration to further reduce the application's latency. This paper also describes our implementation of the iHadoop model, and evaluates its performance against Hadoop, the widely used open source implementation of MapReduce. Experiments using different data analysis applications over real-world and synthetic datasets show that iHadoop performs better than Hadoop for iterative algorithms, reducing execution time of iterative applications by 25% on average. Furthermore, integrating iHadoop with HaLoop, a variant Hadoop implementation that caches invariant data between iterations, reduces execution time by 38% on average.
Interfacial Processes and Influence of Composite Cathode Microstructure Controlling the Performance of All-Solid-State Lithium Batteries (2017)

All-solid-state lithium-ion batteries have the potential to become an important class of next-generation electrochemical energy storage devices. However, for achieving competitive performance, a better understanding of the interfacial processes at the electrodes is necessary for optimized electrode compositions to be developed. In this work, the interfacial processes between the solid electrolyte (Li<sub>10</sub>GeP<sub>2</sub>S<sub>12</sub>) and the electrode materials (In/InLi and Li<sub>x</sub>CoO<sub>2</sub>) are monitored using impedance spectroscopy and galvanostatic cycling, showing a large resistance contribution and kinetic hindrance at the metal anode. The effect of different fractions of the solid electrolyte in the composite cathodes on the rate performance is tested. The results demonstrate the necessity of a carefully designed composite microstructure depending on the desired applications of an all-solid-state battery. While a relatively low mass fraction of solid electrolyte is sufficient for high energy density, a higher fraction of solid electrolyte is required for high power density.
Adaptive frameless rendering (2005)

We propose an adaptive form of frameless rendering with the potential to dramatically increase rendering speed over conventional interactive rendering approaches. Without the rigid sampling patterns of framed renderers, sampling and reconstruction can adapt with very fine granularity to spatio-temporal color change. A sampler uses closed-loop feedback to guide sampling toward edges or motion in the image. Temporally deep buffers store all the samples created over a short time interval for use in reconstruction and as sampler feedback. GPU-based reconstruction responds both to sampling density and space-time color gradients. Where the displayed scene is static, spatial color change dominates and older samples are given significant weight in reconstruction, resulting in sharper and eventually antialiased images. Where the scene is dynamic, more recent samples are emphasized, resulting in less sharp but more up-to-date images. We also use sample reprojection to improve reconstruction and guide sampling toward occlusion edges, undersampled regions, and specular highlights. In simulation our frameless renderer requires an order of magnitude fewer samples than traditional rendering of similar visual quality (as measured by RMS error), while introducing overhead amounting to 15% of computation time.
FD/I-Based personalized recommendation in Context-aware Application (2007)

Personalized recommendation is an important application of context-aware system and is being used widely. However, most existed systems provide personalized information to users only based on user preferences or user activity history. Few applications consider the user's psychology characteristics before they make recommendation. We take this characteristic into consideration, and believe the psychology knowledge is valuable to personalized recommendation. In this paper we propose a new way for personalized recommendation in context-aware system which named field dependence/independence-based recommendation. Field dependence/independence is a cognitive style of human and reflects the requirement of user about information. We compare the field dependence user with field independence user in context-aware environment, and make field dependence/independence be a characteristic parameter in personalized recommendation. We implement it and the performance seems excellent.
HARMONIC DRIVE SELECTION (2014)

The variety of types and sizes currently in production harmonic drive is a problem in their rational choice. Properly selected harmonic drive must meet certain requirements during operation, and achieve the anticipated service life. The paper discusses the problems associated with the selection of the harmonic drive. It also presents the algorithm correct choice of harmonic drive. The main objective of this study was to develop a computer program that allows the correct choice of harmonic drive by developed algorithm.
Teaching graphs to visually impaired students using an active auditory interface (2006)

We present our ongoing research in the communication of graphs and relational information to blind computer science students. We have developed a system called exPLoring graphs at UMB (PLUMB) that displays a drawn graph on a tablet PC and uses auditory cues to help a blind user navigate the graph. Beyond Computer Science education, this work has applications to assist blind individuals in navigation, map manipulation and other applications that require graph visualization.
Structure-activity studies of potassium channel opening in pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas (1992)

Potassium channel opening activity for pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas, has been assessed through simultaneous measurement of spontaneous contractile activity and stimulation of 86Rb+ efflux from rat portal veins loaded with 86Rb+. The good correlation between these two effects suggests that the vasodilator activity of the compounds is directly attributable to an increased opening of potassium channels. The resulting quantitative in vitro data has been used to analyze the structure-activity relationships for potassium channel opening, allowing the biological activity to be rationalized in terms of a pharmacophore involving a hydrogen-bond-acceptor element, a hydrogen-bond-donor element, and a lipophilic binding group. A model for the binding of pinacidil-related compounds to their potassium channel receptor has been developed, and compounds designed to test this model have been synthesized and tested. Prototropic equilibria are implicated as playing a fundamental role in determining the hydrogen-bonding ability of the compounds, and conformational changes in the receptor are invoked to explain disparities in the chiral recognition of lipophilic groups in different compounds.
Immunohistologic Evaluation of the Lymphoreticular Infiltrate of Human Central Nervous System Tumors2 (1979)

Forty-five nervous system tumors (9 glioblastomas, 9 meningiomas, 15 assorted primary neural tumors including 3 medulloblastomas, and 12 brain tumors metastatic to the brain were analyzed for their content of lymphocytes, granulocytes, and macrophages. Cell suspensions were prepared by enzymatic digestion; lymphocytes and granulocytes were quantitated by morphology following cytocentrifugation, and macrophages were quantitated by IgG EAC (erythrocyte-antibody-complement) rosette formation. EA (erythrocyte-antibody) adsorption to sections of tumor was employed to determine the distribution of the IgG Fc receptor-positive cells within the tumors and to serve as quality control for selective release of Fc receptor-positive cells by enzyme digestion. The 9 glioblastomas had a mean macrophage content of 41% (range: 5-78%); the 9 meningiomas, 42% (range: 5-80%); the 3 medulloblastomas, 6% (range: 2-15%); and the metastatic tumors, 21% (range: 2-50%). Lymphocyte contents were variable but generally less than 10%. Most tumors contained less than 10% granulocytes. EA adsorption demonstrated that Fc receptor-positive cells were distributed throughout the tumor mass, although different types of patterns were observed. There was an excellent correlation between the percent EAC rosette-positive cells in suspensions and the extent of EA adsorption to the tumor sections. The significance of the study primarily rests in the demonstration that most nervous system tumors contain high numbers of infiltrating host cells, primarily macrophages.