gebhart/patrepeval huggingface dataset:
Modulating Effect of Sesamin, a Functional Lignan in Sesame Seeds, on the Transcription Levels of Lipid- and Alcohol-Metabolizing Enzymes in Rat Liver: A DNA Microarray Study (2005)

Sesamin, a major lignan in sesame seeds, has multiple functions such as cholesterol-lowering and anti-hypertensive activities. To investigate the effect of sesamin on gene expression in the liver, a DNA microarray analysis was carried out. The ingestion of sesamin dissolved in olive oil up-regulated the expression of 38 genes, 16 of which encode proteins possessing a lipid-metabolizing function, and 16 of which encode proteins possessing a xenobiotic/endogenous substance metabolizing function. In particular, sesamin significantly increased the expression of beta-oxidation-associated enzymes in peroxisomes and auxiliary enzymes required for degradation, via the beta-oxidation pathway, of unsaturated fatty acids in mitochondria. The ingestion of sesamin also resulted in an increase in the gene expression of acyl-CoA thioesterase involved in acyl-CoA hydrolase and very-long-chain acyl-CoA thioesterase. Interestingly, it induced the expression of the gene for aldehyde dehydrogenase, an alcohol-metabolizing enzyme. These results suggest that sesamin regulates the metabolism of lipids, xenobiotics, and alcohol at the mRNA level.
A simulation of realistic sketching by randomized pencil strokes (2011)

A novel simulation technique for realistic pencil-drawn sketches is proposed. The novelty of the proposed technique lies in incorporation of a randomization factor while sketching a figure out of a set S of (irreducible) digital curve segments. The set S corresponds to a real-world object, which is actually the object to be sketched in an artistic way. The fact that an artist often uses irregular strokes and sub-strokes with varying shades while sketching, is realistically captured in our randomized approach. Some sketched segments get lightly shaded compared to other heavily-shaded ones, and a sub-segment also may be lighter or deeper in shade compared to the rest of the segment - in a pseudo-random or mystic manner - which characterizes our algorithm. Some experimental results have been furnished to demonstrate the efficacy and elegance of the proposed technique.
Locally Assembled Binary (LAB) feature with feature-centric cascade for fast and accurate face detection (2008)

In this paper, we describe a novel type of feature for fast and accurate face detection. The feature is called Locally Assembled Binary (LAB) Haar feature. LAB feature is basically inspired by the success of Haar feature and Local Binary Pattern (LBP) for face detection, but it is far beyond a simple combination. In our method, Haar features are modified to keep only the ordinal relationship (named by binary Haar feature) rather than the difference between the accumulated intensities. Several neighboring binary Haar features are then assembled to capture their co-occurrence with similar idea to LBP. We show that the feature is more efficient than Haar feature and LBP both in discriminating power and computational cost. Furthermore, a novel efficient detection method called feature-centric cascade is proposed to build an efficient detector, which is developed from the feature-centric method. Experimental results on the CMU+MIT frontal face test set and CMU profile test set show that the proposed method can achieve very good results and amazing detection speed.
Value of Breath Hydrogen Analysis in Management of Diarrheal Illness in Childhood (1985)

Breath hydrogen tests were carried out on 157 children either because they had chronic diarrhea or because they were on disaccharide-free diets. Lactose malabsorption was common in patients with postgastroenteritis syndrome (43%), and sucrose malabsorption was readily detected in patients with congenital sucrase-isomaltase deficiency. Secondary sucrose malabsorption and small bowel bacterial overgrowth were also detected. In predicting clinical response to dietary change, the breath hydrogen test, as we perform it, was clearly the most specific and sensitive and had a predictive accuracy of 96%. Duodenal biopsy results obtained from 48 of the children gave a 23% incidence of misleading disaccharidase results (16.7% falsely normal, 6.3% falsely abnormal), but biopsy remains vital in the diagnosis of congenital sucrase-isomaltase deficiency. False negative breath hydrogen results were obtained on occasions (4%) but in most instances were related to recent antimicrobial therapy or failure of the breath test mechanics (e.g., vomiting, length of sampling).
A tool that uses human factors to simplify model building and facilitate more accurate strategic decisions (2007)

Hypotonia-cystinuria syndrome (HCS) and 2p21 deletion syndrome are two recessive contiguous gene deletion syndromes associated with cystinuria type I. In HCS patients, only SLC3A1 and PREPL are disrupted. In the 2p21 deletion syndrome, two additional genes (C2orf34 and PPM1B) are lost. Molecular analysis of the SLC3A1/PREPL locus was performed in the patients using quantitative polymerase chain reaction (PCR) methods. HCS in both siblings was confirmed with the deletion screen of the SLC3A1/PREPL locus. Fine mapping of the breakpoint revealed a deletion of 77.4 kb, including three genes: SLC3A1, PREPL and C2orf34. Features not present in classical HCS were a mild/moderate mental retardation and a respiratory chain complex IV deficiency. We report the first patients with a deletion of SLC3A1, PREPL and C2orf34. They present with a phenotype intermediate between HCS and 2p21 deletion syndrome.
G protein modulation of voltage-dependent calcium channels and transmitter release (1993)

Conference Article| May 01 1993 G protein modulation of voltage-dependent calcium channels and transmitter release Annette C. Dolphin; Annette C. Dolphin 1Department of Pharmacology, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF Search for other works by this author on: This Site PubMed Google Scholar Hugh A. Pearson; Hugh A. Pearson 1Department of Pharmacology, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF Search for other works by this author on: This Site PubMed Google Scholar Anatole S. Menon-Johansson; Anatole S. Menon-Johansson 1Department of Pharmacology, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF Search for other works by this author on: This Site PubMed Google Scholar Marva I. Sweeney; Marva I. Sweeney 1Department of Pharmacology, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF Search for other works by this author on: This Site PubMed Google Scholar Kathy Sutton; Kathy Sutton 1Department of Pharmacology, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF Search for other works by this author on: This Site PubMed Google Scholar Elaine Huston; Elaine Huston 1Department of Pharmacology, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF Search for other works by this author on: This Site PubMed Google Scholar G. P. Cullen; G. P. Cullen 1Department of Pharmacology, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF Search for other works by this author on: This Site PubMed Google Scholar Roderick H. Scott Roderick H. Scott *Department of Physiology, St George's Hospital Medical School, London SWI7 ORE, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1993) 21 (2): 391–395. https://doi.org/10.1042/bst0210391 Article history Received: December 30 1992 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Annette C. Dolphin, Hugh A. Pearson, Anatole S. Menon-Johansson, Marva I. Sweeney, Kathy Sutton, Elaine Huston, G. P. Cullen, Roderick H. Scott; G protein modulation of voltage-dependent calcium channels and transmitter release. Biochem Soc Trans 1 May 1993; 21 (2): 391–395. doi: https://doi.org/10.1042/bst0210391 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: C, channel in closed resting state, C*, channel in modified closed state, DHP, dihydropyridine, DRG, dorsal root ganglion, GABA, γ-aminobutyric acid, GTP[S], guanosine 5′-[γ-thio]-triphosphate This content is only available as a PDF. © 1993 Biochemical Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
Percutaneous embolic occlusion of an inadvertent surgical aortocoronary vein fistula (1982)

Abstract The previously recommended approach to inadvertent surgically placed aortocoronary vein fistula has been patient observation or surgical closure with rebypass. A third alternative, percutaneous embolic occlusion, is reported here and is recommended for use by those experienced with embolic techniques in situations where repeat bypass is not necessary and the existence of the fistula is felt to be detrimental to the patient's condition.
The first international Chinese word segmentation Bakeoff (2003)

This paper presents the results from the ACL-SIGHAN-sponsored First International Chinese Word Segmentation Bakeoff held in 2003 and reported in conjunction with the Second SIGHAN Workshop on Chinese Language Processing, Sapporo, Japan. We give the motivation for having an international segmentation contest (given that there have been two within-China contests to date) and we report on the results of this first international contest, analyze these results, and make some recommendations for the future.
Epitaxial-Graphene RF Field-Effect Transistors on Si-Face 6H-SiC Substrates (2009)

We report dc and the first-ever measured small-signal radio-frequency (RF) performance of epitaxial-graphene RF field-effect transistors (FETs), where the epitaxial-graphene layer is formed by graphitization of 2-in-diameter Si-face semi-insulating 6H-SiC (0001) substrates. The gate is processed with a metal gate on top of a high-k Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> gate dielectric deposited via an atomic-layer-deposition method. With a gate length (L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> ) of 2 mum and an extrinsic transconductance of 148 mS/mm, the extrinsic current-gain cutoff frequency (f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> ) is measured as 4.4 GHz, yielding an extrinsic f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> ldr L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> of 8.8 GHz middot mum. This is comparable to that of Si NMOS. With graphene FETs fabricated in a layout similar to those of Si n-MOSFETs, on-state current density increases dramatically to as high as 1.18 A/mm at Vds = 1 V and 3 A/mm at Vds = 5 V. The current drive level is the highest ever observed in any semiconductor FETs.
PEGylation of αα-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG αα-Hbs (2014)

PEGylation of intramolecularly crosslinked Hb has been studied here to overcome the limitation of dissociation of Hb tetramers. New hexa and deca PEGylated low oxygen affinity PEG-ααHbs have been generated. Influence of PEG conjugation chemistry and the PEG shell structure on the functional properties as well as PEGylation induced plasma expander like properties of the protein has been delineated. The results have established that in the design of PEG-Hbs as oxygen therapeutics, the influence of conjugation chemistry and the PEG shell structure on the oxygen affinity of Hb needs to be optimized independently besides optimizing the PEG shell structure for inducing resuscitation fluid like properties.
Isolation of Genomic Sequence Encoding a Biologically Active Bovine TGF- α Protein (1990)

Genomic clones encoding bovine TGF-alpha were identified by hybridization with probes derived from human TGF-alpha sequence. Nucleotide sequence of the clones predicts that mature bovine TGF-alpha is a 50 amino acid polypeptide which shares 96% and 92% homology with human and rat TGF-alpha, respectively. Bovine TGF-alpha with the predicted sequence was chemically synthesized and tested for activity. Synthetic bovine TGF-alpha competes in a radioreceptor assay with labelled mouse EGF with activity parallel to that of human TGF-alpha and mouse EGF. The mitogenic activity of bovine TGF-alpha is comparable to that of human EGF in causing proliferation of bovine mammary epithelial cells. An approximately 5.0 kilobase RNA transcript is observed in polyadenylated RNA from MDBK cells by Northern blot analysis. The polymerase chain reaction detects the presence of a TGF-alpha transcript in many bovine tissues. These data indicate that bovine TGF-alpha may be a normal regulator of cell growth in the bovine animal.
Injuries to the Lateral Femoral Cutaneous Nerve During Spine Surgery (2000)

Injuries to the lateral femoral cutaneous nerve during spine surgery are frequent, and patients should be informed of the possible risk. It usually has a benign course, but some preventive steps should be taken: keep posterior to the anterior superior iliac spine and minimize retraction when harvesting a bone graft, pad the posts of the Hall-Relton frame over the anterior superior iliac crest, and avoid traction on the psoas muscle during the retroperitoneal dissection.
Preparation of crosslinked β‐cyclodextrin polymer beads and their application as a sorbent for removal of phenol from wastewater (2008)

Abstract BACKGROUND: Phenols are commonly encountered in aqueous effluents from various manufacturing processes such as oil refineries, coke plants, and phenolic resin plants, and are toxic substances that should be removed from the aquatic environment. This paper reports on the preparation of beaded crosslinked β‐CyD polymers, and the removal of phenol by the β‐CyD adsorbent from raw industrial wastewater discarded from phenolic resin processing. RESULTS: Crosslinked β‐CyD prepolymer was synthesized by treatment of β‐CyD with hexamethylene diisocyanate (HDI) at a molar ratio of 1:8. The suspension of the resulting powdery prepolymer in aqueous sodium alginate was added dropwise into an aqueous calcium chloride solution to precipitate the spherical β‐CyD prepolymer gels. The spherical prepolymer gel was lyophilized and re‐crosslinked with HDI to provide the β‐CyD polymer beads. The physical properties of the beads were as follows: average diameter: 3.4 mm; average compressive strength: 2.17 MPa; porosity: 47.0%; specific surface area: 3.48 m 2 g −1 . The removal of phenol from raw industrial phenolic wastewater with the β‐CyD polymer beads was carried out in either a shaker or an upflow column at 25 °C. After seven episodes of accumulated adsorption, the initial phenol concentration of 89000 ppm decreased to as low as 350 ppm in the shaker and 490 ppm in the upflow column. CONCLUSION: Adsorbent [β‐CyD/HDI(1/8)]/HDI polymer beads having a good regular shape and high mechanical stability were newly prepared by a stepwise crosslinking method. The results of sorption experiments show that the beads exhibit high sorption capacities for phenolics in raw industrial wastewater. Copyright © 2008 Society of Chemical Industry
Glycol Production—Hydration of Ethylene Oxide (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGlycol Production—Hydration of Ethylene OxideDonald F. Othmer and Mahesh S. ThakarCite this: Ind. Eng. Chem. 1958, 50, 9, 1235–1244Publication Date (Print):September 1, 1958Publication History Published online1 May 2002Published inissue 1 September 1958https://doi.org/10.1021/ie50585a025RIGHTS & PERMISSIONSArticle Views2512Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts
Selective Inhibitors of the Mutant B-Raf Pathway: Discovery of a Potent and Orally Bioavailable Aminoisoquinoline (2009)

The discovery and optimization of a novel series of aminoisoquinolines as potent, selective, and efficacious inhibitors of the mutant B-Raf pathway is presented. The N-linked pyridylpyrimidine benzamide 2 was identified as a potent, modestly selective inhibitor of the B-Raf enzyme. Replacement of the benzamide with an aminoisoquinoline core significantly improved kinase selectivity and imparted favorable pharmacokinetic properties, leading to the identification of 1 as a potent antitumor agent in xenograft models.
The impact of uncertainties in the CT conversion algorithm when predicting proton beam ranges in patients from dose and PET-activity distributions (2010)

The advantages of a finite range of proton beams can only be partly exploited in radiation therapy unless the range can be predicted in patient anatomy with <2 mm accuracy (for non-moving targets). Monte Carlo dose calculation aims at 1-2 mm accuracy in dose prediction, and proton-induced PET imaging aims at ∼2 mm accuracy in range verification. The latter is done using Monte Carlo predicted PET images. Monte Carlo methods are based on CT images to describe patient anatomy. The dose calculation algorithm and the CT resolution/artifacts might affect dose calculation accuracy. Additionally, when using Monte Carlo for PET range verification, the biological decay model and the cross sections for positron emitter production affect predicted PET images. The goal of this work is to study the effect of uncertainties in the CT conversion on the proton beam range predicted by Monte Carlo dose calculations and proton-induced PET signals. Conversion schemes to assign density and elemental composition based on a CT image of the patient define a unique Hounsfield unit (HU) to tissue parameters relationship. Uncertainties are introduced because there is no unique relationship between HU and tissue parameters. In this work, different conversion schemes based on a stoichiometric calibration method as well as different numbers of tissue bins were considered in three head and neck patients. For Monte Carlo dose calculation, the results show close to zero (<0.5 mm) differences in range using different conversion schemes. Further, a reduction of the number of bins used to define individual tissues down to 13 did not affect the accuracy. In the case of simulated PET images we found a more pronounced sensitivity on the CT conversion scheme with a mean fall-off position variation of about 1 mm. We conclude that proton dose distributions based on Monte Carlo calculation are only slightly affected by the uncertainty on density and elemental composition introduced by unique assignment to each HU if a stoichiometric calibration is used. Calculated PET images used for range verification are more sensitive to conversion uncertainties causing an intrinsic limitation due to CT conversion alone of at least 1 mm.
Age and Fentanyl Pharmacokinetics (1983)

Fentanyl pharmacokinetics was compared in two groups of adult patients, one group (n = 5) aged less than 50 years, and one group (n = 4) aged greater than 60 years. Despite equivalent doses of fentanyl (10 microgram/kg IV), serum drug concentrations were significantly higher in the older patient group. This was reflected by a prolonged terminal elimination half-life in the elderly compared with the younger patients (945 versus 265 minutes, respectively, p less than 0.005). Volumes of the central compartment and volumes of drug distribution were similar in both patient groups. However, drug clearance was markedly decreased in the elderly (265 versus 991 ml/min, p less than 0.005). These data suggest that a given dose of fentanyl will be clinically effective for a longer period in older patients than in younger patients.
Wire-Fed Additive Manufacturing of Transparent Glass Parts (2015)

This paper presents a new technique for additive manufacturing of transparent glass. In this process, transparent glass is wire-fed into a laser generated melt pool, which solidifies as the work piece is moved relative to a stationary laser beam. The key parameters are identified in terms of their effects on the morphology and transparency of printed walls. The relationship between these parameters is studied experimentally. It is demonstrated that the process parameters strongly affect the morphology and proper selection of the scan speed, feed rate and laser power can produce optimum results. A key advantage of this process relative to powder bed techniques is the ability to form optically transparent parts. The process parameters also determine the transmissivity of the final sample. The transmissivity is measured experimentally for builds with different process parameters.
Photochemical deoxygenation of aryl sulfoxides (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical deoxygenation of aryl sulfoxidesGeorge M. Gurria and Gary H. PosnerCite this: J. Org. Chem. 1973, 38, 13, 2419–2420Publication Date (Print):June 1, 1973Publication History Published online1 May 2002Published inissue 1 June 1973https://pubs.acs.org/doi/10.1021/jo00953a034https://doi.org/10.1021/jo00953a034research-articleACS PublicationsRequest reuse permissionsArticle Views283Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts