gebhart/patrepeval huggingface dataset:
Symmetrical Cyanostilbenes (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSymmetrical CyanostilbenesJoseph B. Niederl and Albert ZieringCite this: J. Am. Chem. Soc. 1942, 64, 10, 2486–2487Publication Date (Print):October 1, 1942Publication History Published online1 May 2002Published inissue 1 October 1942https://pubs.acs.org/doi/10.1021/ja01262a077https://doi.org/10.1021/ja01262a077research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Overproduction and nucleotide sequence of the respiratory D-lactate dehydrogenase of Escherichia coli (1985)

Recombinant DNA plasmids containing the gene for the membrane-bound D-lactate dehydrogenase (D-LDH) of Escherichia coli linked to the promoter PL from lambda were constructed. After induction, the levels of D-LDH were elevated 300-fold over that of the wild type and amounted to 35% of the total cellular protein. The nucleotide sequence of the D-LDH gene was determined and shown to agree with the amino acid composition and the amino-terminal sequence of the purified enzyme. Removal of the amino-terminal formyl-Met from D-LDH was not inhibited in cells which contained these high levels of D-LDH.
CAD-Based Parametric Cross-Section Designer for Gas Turbine Engine MDO Applications (2007)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
Atrial natriuretic peptide and osteopontin are useful markers of cardiac disorders in mice. (2007)

Biomarkers are not established for cardiovascular phenotyping in mice. We compared the use of echocardiography with the determination of N-terminal propeptide of the atrial natriuretic peptide (Nt-proANP) and osteopontin (Opn). We measured plasma Nt-proANP and Opn levels in (1) the inbred strains C57BL/6, BALB/c, C3H/He, DBA/2, FVB/N, 129S1/Sv; (2) a surgical model of nonischemic myocardial infarction; and (3) delta-sarcoglycan (Sgcd) and calsarcin 1 [also known as myozenin 2 (Myoz2)] knockout models of cardiomyopathy. Left ventricular function was assessed as fractional shortening (FS) by echocardiography in conscious mice. Plasma Nt-proANP exhibited marked variability and ranged from 0.31 +/- 0.19 (C57BL/6 male mice) to 1.34 +/- 0.43 nmol/l (DBA/2 female mice), depending on sex, age, and genetic background. Opn was less variable than Nt-proANP and was decreased significantly in C3H/He and DBA/2 throughout the 16 wk of study. Nt-proANP increased temporarily in mice with myocardial injury. In contrast, Opn increased in both operated and sham-treated mice. Nt-proANP was inversely correlated with FS and distinguished controls from Sgcd and Myoz2 mutants with 100% sensitivity and 71% specificity. Opn was increased in Sgcd mutants, which exhibited only mildly reduced FS but marked myocardial degeneration and fibrosis. Both of these histologic features were absent in Myoz2 mutants. Nt-proANP is an early marker of cardiac disease and is suitable for age- and sex-matched comparisons between groups of transgenic and matched control mice. Opn is useful to detect inflammatory and degenerative myocardial disorders that may be missed by echocardiography.
Performance and energy efficiency of mobile data offloading with mobility prediction and prefetching (2013)

We present a detailed evaluation of procedures that exploit mobility prediction and prefetching to enhance offloading of traffic from mobile networks to WiFi hotspots, for both delay tolerant and delay sensitive traffic. We consider empirical measurements and evaluate the percentage of offloaded traffic, data transfer delay, and energy consumption of the proposed procedures. Our results illustrate how various factors such as mobile, WiFi and hotspot backhaul throughput, data size, number of hotspots, along with time and throughput estimation errors, influence the performance and energy efficiency of mobile data offloading enhanced with mobility prediction and prefetching.
Synthesis of nanostructured tetragonal ZrO 2 of enhanced thermal stability (2006)

Hydrous zirconia particles of nanometric dimensions were synthesized via forced hydrolysis of zirconyl chloride.Prolonged aging at 100C in the mother liquor and subsequent calcination produced a single-phase tetragonal ZrO 2 of enhanced thermal stability with the narrow size and pore distributions.The influence of the preparation conditions on the phase composition of the resultant zirconium dioxide was examined using structural (XRD, SEM/TEM) and spectroscopic (Raman) methods, supported by thermal analysis (DTA/TG, DSC) and N 2 -porosimetry.The nature of the parent salt, pH of the solution, the temperature of precipitation and aging, were found to be the key parameters of the successful synthesis.The sequence of mechanistic steps invoked to account for the formation of t-ZrO 2 was rationalized using the concepts of zirconium aquatic chemistry.
Embryonic cholecystitis and defective gallbladder contraction in the <i>Sox17</i>-haploinsufficient mouse model of biliary atresia (2017)

The gallbladder excretes cytotoxic bile acids into the duodenum through the cystic duct and common bile duct system. <i>Sox17</i> haploinsufficiency causes biliary atresia-like phenotypes and hepatitis in late organogenesis mouse embryos, but the molecular and cellular mechanisms underlying this remain unclear. In this study, transcriptomic analyses revealed the early onset of cholecystitis in <i>Sox17</i><sup>+/-</sup> embryos, together with the appearance of ectopic cystic duct-like epithelia in their gallbladders. The embryonic hepatitis showed positive correlations with the severity of cholecystitis in individual <i>Sox17</i><sup>+/-</sup> embryos. Embryonic hepatitis could be induced by conditional deletion of <i>Sox17</i> in the primordial gallbladder epithelia but not in fetal liver hepatoblasts. The <i>Sox17</i><sup>+/-</sup> gallbladder also showed a drastic reduction in sonic hedgehog expression, leading to aberrant smooth muscle formation and defective contraction of the fetal gallbladder. The defective gallbladder contraction positively correlated with the severity of embryonic hepatitis in <i>Sox17</i><sup>+/-</sup> embryos, suggesting a potential contribution of embryonic cholecystitis and fetal gallbladder contraction in the early pathogenesis of congenital biliary atresia.
Membrane probe with pyramidal tips for a bare chip testing (2002)

Bare chips are used in multichip modules for high packaging density and high processing speed devices. Obtaining known good dies (KGD) is a significant problem in achieving high MCM yields. Therefore, a probing technique for bare chips with high reliability is a matter of importance. In order to achieve good contact properties at a low probing pressure, a new membrane probe with pyramidal tips is developed for bare chip testing. By using anisotropic etching of silicon, quadrangular pyramidal pits are formed as the cast of probe tips. By nickel plating these pits, nickel pyramidal tips with copper wiring are formed on the polyimide film. The silicon wafer cast is then dissolved completely by etching. This membrane probe is then attached to a socket. This pyramidal probe is vertically inserted into an aluminum pad. Contact resistance remained stable at 0.1-0.2 /spl Omega/.
Modelling flow pattern transitions for steady upward gas‐liquid flow in vertical tubes (1980)

Abstract Models for predicting flow pattern transitions during steady gas‐liquid flow in vertical tubes are developed, based on physical mechanisms suggested for each transition. These models incorporate the effect of fluid properties and pipe size and thus are largely free of the limitations of empirically based transition maps or correlations.
Characteristic features of an alpha-galactosidase from mung beans (1984)

Two molecular forms, I and II (high and low molecular mass) of alpha-galactosidase were demonstrated in dry mung beans and a multi-step procedure was developed for isolating the tetrameric enzyme I in good yield. Two affinity chromatographic techniques were employed and an overall 10 000-fold purification was achieved. The enzyme was able to catalyse the hydrolysis of alpha-galactosidic linkages as well as agglutinate rabbit erythrocytes (clot formation). The clot was temporary and dissolved on longer incubation, yielding free galactose. The pH optima for both activities were similar. The enzyme also destroyed human-blood-group-B activity and increased H activity. The effect of pH on Km and Vmcx of the enzyme indicated the importance of carboxyl (pK approximately equal to 4.0) and histidine (pK approximately equal to 6.5) groups for activity. This was confirmed by amino acid modification experiments in the absence and presence of the substrate. The stoichiometry of enzyme inactivation showed the probable presence of 12 carboxyl groups and 9 histidine imidazole groups/molecule enzyme in the active site. The effects of modification of the groups on enzymic and hemagglutinating activities were parallel. A model explaining the display of both the activities by the enzyme, is presented in which hemagglutination is shown to be due to the formation of slightly stable enzyme-substrate complex. It is proposed that a true lectin should not alter the covalent status of the binding sugar.
Detection of the induction of Salmonella enterotoxin gene expression by contact with epithelial cells with RT-PCR (2006)

All strains of Salmonella enterica investigated were found to carry the Salmonella enterotoxin gene (stn) as determined by PCR and hybridization studies. However, when using CHO-K1 cells for testing the toxicity of the strains, not all strains showed a toxic effect (cell elongation) on the cells or did so only at a low level. The cultivation of Salmonella in contact with epithelial cells (IEC-6) led to an increase in the production of toxin. The stn gene expression was detectable with the help of the RT-PCR after 3 h of incubation. The RNA of the strains was isolated, transcribed into cDNA (with MMLV-reverse transcriptase) and amplified using PCR. The PCR products were separated electrophoretically using a polyacrylamide gel and detected by silver staining.
Effect of Intravitreal Triamcinolone Acetonide on Susceptibility to Experimental Bacterial Endophthalmitis and Subsequent Response to Treatment (2005)

These data suggest that caution must be exercised when combining intravitreal triamcinolone injection with intraocular surgery.
Non-Steroidal Anti-Inflammatory Drugs and Cognitive Function: Are Prostaglandins at the Heart of Cognitive Impairment in Dementia and Delirium ? (2011)

Studies of non-steroidal anti-inflammatory drugs (NSAIDs) in rheumatoid arthritis imply that inflammation is important in the development of Alzheimer's disease (AD). However, these drugs have not alleviated the symptoms of AD in those who have already developed dementia. This suggests that the primary mediator targeted by these drugs, PGE2, is not actively suppressing memory function in AD. Amyloid-β oligomers appear to be important for the mild cognitive changes seen in AD transgenic mice, yet amyloid immunotherapy has also proven unsuccessful in clinical trials. Collectively, these findings indicate that NSAIDs may target a prodromal process in mice that has already passed in those diagnosed with AD, and that synaptic and neuronal loss are key determinants of cognitive dysfunction in AD. While the role of inflammation has not yet become clear, inflammatory processes definitely have a negative impact on cognitive function during episodes of delirium during dementia. Delirium is an acute and profound impairment of cognitive function frequently occurring in aged and demented patients exposed to systemic inflammatory insults, which is now recognised to contribute to long-term cognitive decline. Recent work in animal models is beginning to shed light on the interactions between systemic inflammation and CNS pathology in these acute exacerbations of dementia. This review will assess the role of prostaglandin synthesis in the memory impairments observed in dementia and delirium and will examine the relative contribution of amyloid, synaptic and neuronal loss. We will also discuss how understanding the role of inflammatory mediators in delirious episodes will have major implications for ameliorating the rate of decline in the demented population.
The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. (1996)

Mutations in the gene lin-17 result in the disruption of a variety of asymmetric cell divisions in Caenorhabditis elegans. We have found that lin-17 encodes a protein with seven putative transmembrane domains. The LIN-17 protein is most similar to the Drosophila Frizzled protein and its vertebrate homologs. Studies using a lin-17-green fluorescent protein translational fusion indicate that lin-17 is expressed in mother cells before asymmetric cell divisions and in both daughter cells after the divisions. Our results suggest that lin-17 encodes a receptor that regulates the polarities of cells undergoing asymmetric cell divisions and raise the possibility that the LIN-17 protein acts as a receptor for the Wnt protein LIN-44, which also controls asymmetric cell divisions.
The Relationship Between Interchannel Time and Level Differences in Vertical Sound Localization and Masking (2011)

Listening experiments were conducted with a pair of vertically arranged loudspeakers. A group of subjects
measured the level of delayed height channel signal at which any subjective effects of the signal became completely
inaudible (masked threshold) as well as that at which the perceived sound image was localised fully at the lower
loudspeaker (localised threshold), at nine different delay times ranging from 0 to 50ms. The sound sources were
anechoic recordings of bongo and cello performance excerpts. At the delay times up to 5ms, source type did not
have a significant effect for both threshold results and neither threshold varied significantly as the delay time
increased. In this time range the average level reduction required for a full image shift was 6~7dB while that for
masking was 9~10dB. At the higher delay times, on the other hand, both thresholds decreased as the delay time
increased and the difference between the two sources in both threshold results was significant. Furthermore, the
relationship between the two thresholds varied depending on the source type.
Front Cover: Macromol. Biosci. 7/2005 (2005)

Front Cover: Polymers with time‐dependent LCST properties are dissolved in aqueous buffers at temperatures below the LCST and then gel upon injection at 37 °C. With time the polymers undergo dissolution when the LCST increases above 37 °C. This suggests that they can be cleared by the kidney when dissolved into its individual 30 000 g/mol polymeric chains. Further details can be found in the Full Paper by B. H. Lee, B. Vernon * on page 629.
Scanning scattering microscope for surface microtopography and defect imaging (1996)

A recently developed optical-scatter instrument, the scanning scattering microscope (SSM) produces two-dimensional images of very small surface features and of variations in surface topography. In its present configuration, the lateral resolution is better than 10 μm and its sensitivity to surface roughness is in the angstrom (rms) range. The performance of the SSM has been demonstrated using calibration gratings, Si(100) surfaces, and Ge thin films grown on silicon; intercomparison also was made with atomic force microscope measurements. These results indicate that this scanned optical technique is a very useful noncontact method for evaluating surface microtopography.
DNA polyintercalating drugs. Proton magnetic resonance studies of a new acridine dimer. Conformations and interactions with mono- and dinucleotides (1976)

The conformation in aqueous solution of one acridine dimer which is able to bisintercalate in DNA (1, 14-bis(5-methoxy-6-chloro-9-acridinyl)-1,5,10,14-tetraazatetradecane tetrahydrochloride) (AcDi) and its interactions with mono- and dinucleotides have been investigated by fast Fourier transform proton magnetic resonance spectroscopy. Variations in chemical shifts of the most distingusihable protons of the acridine dimer with temperature bring evidence of a folded in equilibrium unfolded fast conformational equilibrium in the temperature range of 4-85 degrees C. Equilibrium parameters were estimated. The folded conformation has been deduced from iso-shielding curves of the acridine ring. In the complex between AcDi and 3'- or 5"AMP, and adenine ring is intercalated between the two acridine rings to give a sandwich-like complex. Studies of the interaction with adenylyl(3' leads to 5') adenosine (ApA) show two different complexes in equilibrium with the 3' or 5' moiety of ApA intercalated in the acridine dimer. These conclusions are derived from comparative studies with 2-methoxy-6-chloro-9-(3-dimethylaminopropylamino)acridine dihydrochloride which is the corresponding acridine monomer-(AcMo). In that case the self-association constant was determined. A model of the AcMo-5'-AMP complex was deduced from the analysis of the chemical shifts of the adenine protons. In this model, the N10+-D bond of the acridine points toward the negatively charged phosphate of the nucleotide.
Chapter 10: The Index of Growth Regulation and Its Application (1973)

Biologists have long been concerned with the processes by which animal populations regulate their growth. The biological factors ultimately responsible for this regulation are fertility and mortality; their relative effectiveness in keeping growth within tolerable limits, and generally at, or cyclically around, zero, has been examined in several ways.
Phthalocyanine Photodynamic Therapy: Disparate Effects of Pharmacologic Inhibitors on Cutaneous Photosensitivity and on Tumor Regression (1997)

The phthalocyanines are promising second-generation photosensitizers that are being evaluated for the photodynamic therapy (PDT) of malignant tumors. In vivo studies with the silicon phthalocyanine Pc 4 have shown that it is highly effective at causing regression of RIF-1 tumors in C3H/HeN mice in PDT protocols. Because cutaneous photosensitivity is the major complication of photosensitizers used for PDT, experiments were performed to evaluate the effect of inhibitors of the inflammatory response (cyproheptadine, dexamethasone, pentoxifylline, and tumor necrosis factor alpha [TNF-alpha] antibodies) on Pc 4-induced cutaneous photosensitivity and tumor regression. The C3H/HeN mice were injected with either Pc 4 or Photofrin and were exposed to 86 J/cm2 of filtered radiation emitted from a solar simulator. Animals were irradiated at 1, 3, 7, 10, 14 and 28 days postinjection. Cutaneous photosensitivity was assessed using the murine ear-swelling response. Cyproheptadine, dexamethasone, pentoxifylline and TNF-alpha antibodies were administered prior to illumination to assess their ability to block Pc 4-induced cutaneous photosensitivity and to evaluate whether such treatment adversely influenced Pc 4 PDT-induced tumor regression. Compared to Photofrin, Pc 4 produced cutaneous photosensitivity that was transient, resolving within 24 h, and that could be elicited for only 10 days after administration. In contrast, Photofrin caused photosensitivity that required 4 days to resolve and could be elicited for at least 1 month after it was administered. The Pc 4-induced cutaneous photosensitivity could be blocked by corticosteroids and an inhibitor of vasoactive amines (cyproheptadine). The TNF-alpha gene transcription was found to increase in keratinocytes following treatment with Pc 4 and light. The anti-TNF-alpha antibodies and pentoxifylline, an inhibitor of cytokine transcription, also prevented cutaneous photosensitivity, implicating TNF-alpha in the pathogenesis of Pc 4-induced cutaneous photosensitivity. None of these agents had any effect on Pc 4 PDT-induced tumor regression. Cyproheptadine, dexamethasone, pentoxifylline and TNF-alpha antibodies may be valuable pharmacologic agents in the management of cutaneous photosensitivity associated with PDT without altering the efficacy of this new therapeutic modality. The findings suggest that it should be possible to devise PDT protocols that block cutaneous photosensitivity without impairing the anti-tumor response to the agents.
Synthesis of (+-)-geosmin and the other 1,10-dimethyl-9-decalol isomers (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of (+-)-geosmin and the other 1,10-dimethyl-9-decalol isomersJames A. Marshall and Alan R. HochstetlerCite this: J. Org. Chem. 1968, 33, 6, 2593–2595Publication Date (Print):June 1, 1968Publication History Published online1 May 2002Published inissue 1 June 1968https://pubs.acs.org/doi/10.1021/jo01270a120https://doi.org/10.1021/jo01270a120research-articleACS PublicationsRequest reuse permissionsArticle Views691Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts