gebhart/patrepeval huggingface dataset:
<scp>Net</scp><scp>MHC</scp><scp>stab</scp> – predicting stability of peptide–<scp>MHC</scp>‐I complexes; impacts for cytotoxic <scp>T</scp> lymphocyte epitope discovery (2013)

Major histocompatibility complex class I (MHC-I) molecules play an essential role in the cellular immune response, presenting peptides to cytotoxic T lymphocytes (CTLs) allowing the immune system to scrutinize ongoing intracellular production of proteins. In the early 1990s, immunogenicity and stability of the peptide-MHC-I (pMHC-I) complex were shown to be correlated. At that time, measuring stability was cumbersome and time consuming and only small data sets were analysed. Here, we investigate this fairly unexplored area on a large scale compared with earlier studies. A recent small-scale study demonstrated that pMHC-I complex stability was a better correlate of CTL immunogenicity than peptide-MHC-I affinity. We here extended this study and analysed a total of 5509 distinct peptide stability measurements covering 10 different HLA class I molecules. Artificial neural networks were used to construct stability predictors capable of predicting the half-life of the pMHC-I complex. These predictors were shown to predict T-cell epitopes and MHC ligands from SYFPEITHI and IEDB to form significantly more stable MHC-I complexes compared with affinity-matched non-epitopes. Combining the stability predictions with a state-of-the-art affinity predictions NetMHCcons significantly improved the performance for identification of T-cell epitopes and ligands. For the HLA alleles included in the study, we could identify distinct sub-motifs that differentiate between stable and unstable peptide binders and demonstrate that anchor positions in the N-terminal of the binding motif (primarily P2 and P3) play a critical role for the formation of stable pMHC-I complexes. A webserver implementing the method is available at www.cbs.dtu.dk/services/NetMHCstab.
Fibroblast growth factor 10 enhances bovine oocyte maturation and developmental competence <i>in vitro</i> (2010)

The ability of oocytes to resume meiosis, become fertilized, and generate viable pregnancies is controlled during folliculogenesis by several endocrine and paracrine factors. The aim of this work is to determine whether fibroblast growth factor 10 (FGF10) is an oocyte competent factor. Transcripts for each of the four FGF receptor types (FGFR) were present in cumulus and oocytes after their extraction from the follicles. FGFR1 transcripts predominated in cumulus cells whereas FGFR2 was most abundant in oocytes. Exposing the cumulus-oocyte complexes to FGF10 during in vitro maturation did not affect cleavage rates, but increases (P<0.05) in the percentage of embryos at the 8-16-cell stage on day 3 and at the blastocyst stage on day 7, which were evident in FGF10-supplemented oocytes. The progression of oocytes through meiosis and cumulus expansion was increased (P<0.05) by FGF10. The importance of the endogenous sources of FGFs was examined by adding anti-FGF10 IgG during oocyte maturation. Blocking endogenous FGF10 activity decreased (P<0.05) the percentage of oocytes developing into blastocysts and limited (P<0.05) cumulus expansion. Expression profiles of putative cumulus and oocyte competency markers were examined for their involvement in FGF10-mediated responses. FGF10 influenced the expression of CTSB and SPRY2 in cumulus cells and BMP15 in oocytes. In summary, this work provides new insight into the importance of FGFRs and locally derived FGF10 during oocyte maturation in cattle. Its subsequent impact on in vitro embryo development implicates it as a noteworthy oocyte competent factor.
Functional Analysis of a New Polymorphism in the Human TNF α Gene Promoter (1995)

In this paper the functional relevance of a TNFA promoter polymorphism, a G/A polymorphic sequence at position -238, was tested by analysing its influence on TNF alpha production upon in vitro stimulation of monocytes from 78 healthy, unrelated individuals by lipopolysaccharide (LPS) or after allogenic stimulation in a panel of 32 healthy individuals. All TNFA-A positive individuals were either DR3 or DR7 positive, confirming the previously reported strong linkage disequilibrium of the TNFA-A allele with the two extended haplotypes (B18, F1C30, DR3) and (B57, SC61, DR7). No individuals homozygous for the TNFA-A allele were present in the panel. The mean level of TNF alpha production was not significantly different in TNFA-G/G homozygous and in TNFA-A/G heterozygous individuals after LPS stimulation of monocytes (P = 0.35) or after allogenic stimulation (P = 0.7). After LPS and allogenic stimulation DR3 positive individuals had a higher mean TNF production. This could not be further differentiated by typing for TNF -283.
Very Efficient Single-Photon Sources Based on Quantum Dots in Photonic Wires (2014)

We review the recent development of high efficiency single photon sources based on a single quantum dot in a photonic wire. Unlike cavity-based devices, very pure single photon emission and efficiencies exceeding 0.7 photon per pulse are jointly demonstrated under non-resonant pumping conditions. By placing a tip-shaped or trumpet-like tapering at the output end of the wire, a highly directional Gaussian far-field emission pattern is obtained. More generally, a photonic wire containing a quantum dot appears as an attractive template to explore and exploit in a solid-state system the unique optical properties of "one-dimensional atoms".
Long-life cathode for the Berkeley-type ion source (1977)

Preliminary experiments indicate that a hollow cathode, made from impregnated tungsten emitters, can be adapted for the Lawrence Berkeley Laboratory (LBL)/Lawrence Livermore Laboratory (LLL) ion source. Such cathodes could be the basis of a long life, continuously operated positive-ion source.
Pd(OAc)<sub>2</sub>/DABCO as an Inexpensive and Efficient Catalytic System for Hiyama Cross-Coupling Reactions of Aryl Halides with Aryltrimethoxysilanes (2005)

Pd(OAc)2/DABCO was found to be an inexpensive and efficient catalyst system for Hiyama cross-coupling reactions of aryl halides with aryltrimethoxysilanes. In the presence of Pd(OAc)2, DABCO, and TBAF, coupling of a number of aryl halides with aryltrimethoxysilanes underwent efficiently to afford the corresponding cross-coupled products in moderate to excellent yields.
RS data fusion by local mean and variance matching algorithms: their respective efficiency in a complex urban context (2002)

Two methods of remote sensing (RS) data fusion using local mean and variance matching (LMVM) algorithms are tested on one complex urban subset of an IKONOS image of Toulouse. This image is composed by 4 multi-spectral (XS) bands and 1 panchromatic (P) band. Their spatial resolutions are respectively 4 and 1 m. The first scheme is a band by band fusion and the second one is a combined bands fusion using the INR (intensity normalized ratio) transform. Both methods depend on one single parameter, the size of a convolution window used for local means and variances computation. In an urban area, the setting of the window-size parameter is very highly sensitive to the structures with high spatial frequency and to the variable urbanization rate. As we have demonstrated in the past, the window-size determines the importance of the textural information coming from the panchromatic high spatial resolution (P HSR) image injected in the fused product. The weight of injected textural information is generally proportional to the magnitude of this parameter but the spectral information conserved from the multi-spectral low spatial resolution (XS LSR) image decreases with this parameter. The respective efficiency of the two schemes in the /sub c/omplex urban context of Toulouse is compared for different window-sizes using global correlation and visual computer assisted image interpretation. From this comparison, the 11/spl times/11 convolution widow-size gives very good results for the first scheme on spectral and textural points of view. The second scheme is not appropriate to get high quality products.
Ethanoligenens harbinense gen. nov., sp. nov., isolated from molasses wastewater (2006)

Two strictly anaerobic bacterial strains (YUAN-3T and X-29) were isolated from anaerobic activated sludge of molasses wastewater in a continuous stirred-tank reactor. The strains were Gram-positive, non-spore-forming, mesophilic and motile. Cells were regular rods (0.4-0.8 x 1.5-8.0 microm) and occurred singly, in pairs and sometimes in chains of up to eight. Autoaggregative and autofluorescent growth of strain YUAN-3T and non-aggregative growth of strain X-29 were observed at 20-44 degrees C and pH 3.5-9.0. Both strains hydrolysed gelatin and aesculin and fermented several kinds of mono-, di- and oligosaccharides. Fermentation end products formed from glucose were acetate, ethanol, hydrogen and carbon dioxide. The predominant cellular fatty acids were the branched-chain fatty acids iso-C(16 : 0) (44.18 %) and iso-C(12 : 0) (26.67 %). The DNA G+C contents of strains YUAN-3T and X-29 were 47.8 and 49.0 mol%, respectively. Phylogenetic analysis based on 16S rRNA gene sequences revealed that the isolates represent a novel phyletic sublineage within the Clostridium cellulosi rRNA cluster, with <92 % 16S rRNA gene sequence similarity to currently known species. On the basis of polyphasic evidence from this study, it is proposed that the unknown bacterium should be classified in a new genus as a novel species, Ethanoligenens harbinense gen. nov., sp. nov. The type strain of Ethanoligenens harbinense is YUAN-3T (=JCM 12961T = CGMCC 1.5033T).
Steam Turbines for Modern Fossil-Fuel Power Plants (2021)

Presenting the newest approaches to the design and operation of steam turbines, this book also explores modern techniques for refurbishment of aging units. It covers recent engineering breakthroughs and new approaches to transient operating conditions, as well as improved information support for operational personnel. An authoritative guide for power plant engineers, operators, owners and designers on all of these crucial developments, this book fully describes and evaluates the most important new design and operational improvement opportunities for the full spectrum of today's steam turbines – from the newest and most advanced to the more common existing systems.
Total Removal of Baseline Drift from ECG Signal (2007)

Baseline drift in ECG signal is the biggest hurdle in visualization of correct waveform and computerized detection of wave complexes based on threshold decision. The baseline drift may be linear, static, nonlinear or wavering. Reducing the baseline drift to a near zero value greatly helps in visually inspecting the morphology of the wave components as well as in computerized detection and delineation of the wave complexes. The algorithm is developed for computer implementation using Matlab. It deploys least squares error correction and correction based on overall median of individual single lead data, to reduce baseline drift. QRS complexes are then detected to find RR intervals of the waveform. Finally, median based correction is implemented in the RR interval and a drift free signal is achieved. This can help cardiologists significantly
Soft-matter electronics and multifunctional materials with polydisperse liquid metal suspensions: Material architecture, principles, and applications to programmable matter (2017)

Soft elastomers embedded with a polydisperse suspension of liquid metal (LM) droplets exhibit a unique and extraordinary combination of electrical, thermal, and mechanical properties. Eutectic gallium-indium (EGaIn) LM alloy is used for the dispersion phase on account of its low viscosity, negligible toxicity, and ability to form an emulsion with liquid polymer. Because the alloy is liquid at room temperature, it can alter the electrical and thermal properties of the composite - giving it metal-like bulk features - while preserving the mechanics of the elastomer matrix. These soft multifunctional materials can function as stretchable circuit wiring, high-k dielectric insulators, or heat dissipating films in a broad range of emerging “soft-matter” technologies. In particular, we look at applications to physically-reconfigurable system capable of reversible shape change.
In Vitro Inhibition of Hepatitis B Virus Replication by 2',3'-Dideoxyguanosine, 2',3'-Dideoxyinosine, and 3'-Azido-2',3'-Dideoxythymidine in 2.2.15 (PR) Cells (1991)

Hep G2-derived hepatoblastoma cells (2.2.15), which actively produce hepatitis B virus (HBV), were cultured in the presence of 2',3'-dideoxyguanosine (ddG), 2',3'-dideoxyinosine, or 3'-azido-2',3'-dideoxythymidine (AZT). ddG was the most potent agent. It diminished viral replication by up to 95%, as assessed by the amount of episomal HBV DNA, without impairing cellular growth. AZT was the least effective against HBV. Northern blot analysis revealed no apparent difference in the pregenomic viral RNA profile, suggesting that these dideoxynucleosides suppress reverse transcription in the replicative cycle of HBV. The effect of varying the time of drug exposure showed that these agents can suppress HBV replication even when added late in culture. HBV replication in another 2.2.15 cell population of the same lineage was affected by ddG differently, which may enable the investigation of phenotypic or genetic alterations during culture. The present data suggest that some 2',3'-dideoxynucleosides can exert a potent antiviral activity against HBV in vitro, at least under certain circumstances, although the data do not prove that any of these agents have utility in patients with hepatitis.
Network coding for non-invasive Wireless Body Area Networks (2010)

During recent years Wireless Body Area Networks (WBANs) have been experienced continuous developments by researchers both in academia as well as industry due to its capabilities and various promising applications, for instance, in the areas of healthcare, sports, military, etc. One of the crucial requirements in designing a WBAN, especially, for the healthcare applications is network reliability since it is related to life in patients. However, due to the close proximity of the network to the human body, electromagnetic waves affect the human body should be extremely low. Thus, a WBAN requires a low transmission power meaning that a sensor node does not transmit its data directly to a monitoring device or a gateway but the data are forwarded by a relay node. In this study, we apply the assistance of a relay combining with network coding design to improve network reliability of a WBAN at very low computational and hardware cost. An Unequally Error Protection (UEP) concept is cooperated with network coding at the relay for different classes of data packets corresponding to WBAN applications.
Bandwidth Efficient Architectures for Convolutional Neural Network (2018)

In recent years, Convolutional Neural Network (CNN) has been rapidly evolving and the real-time CNN implementations in embedded systems are becoming highly demanding. It is necessary that high performance and real time CNN based implementations be realized in local processors. Conventional approaches designing CNN accelerators focus on reducing the computational workload of CNNs. However, the limited external memory bandwidth has become the main bottleneck of CNN acceleration in embedded systems. Because in deep and large CNN models the feature map pixels and weights, which are numerous and must be stored in external memories, need to be exchanged between off-chip and on-chip memories frequently. Hence the performance is constrained by the limited external memory bandwidth. In this paper, bandwidth efficient architectures for CNN implementation are proposed. The intermediate pixel data are stored on chip and kernel weights are transferred in an efficient way. Compared to mainstream CNN implementation methods, the proposed architectures can efficiently utilize external memory bandwidth while preserving the original throughput.
Spectacle lenses designed for the modified Listing eye rotation (2004)

Knowledge of the way the eye rotates when changing gaze direction is important for the lens design process. Listing's law of eye rotation conveniently describes that rotation for distant vision. Here, a recently discovered departure from Listing's law in near vision is examined. Although lens designs that accommodate the modified rotations can be produced, as demonstrated here, the benefits to the wearer are unlikely to be perceptible except perhaps in cases of highly astigmatic vision.
Hypomutability in Fanconi anemia cells is associated with increased deletion frequency at the HPRT locus. (1990)

Fanconi anemia (FA) is an inherited human disorder associated with a predisposition to cancer and characterized by anomalies in the processing of DNA cross-links and certain monoadducts. We reported previously that the frequency of psoralen-photoinduced mutations at the HPRT locus is lower in FA cells than in normal cells. This hypomutability is shown here to be associated with an increased frequency of deletions in the HPRT gene when either a mixture of cross-links and monoadducts or monoadducts alone are induced. Molecular analysis of mutants in the HPRT gene was carried out. In normal cells the majority of spontaneous and induced mutants are point mutations whereas in FA deletion mutations predominate. In that case a majority of mutants were found to lack individual exons or small clusters of exons whereas in normal cells large (complete or major gene loss) and small deletions are almost equally represented. Thus we propose that the FA defect lies in a mutagenic pathway that, in normal cells, involves bypassing lesions and subsequent gap filling by a recombinational process during replication.
FACTORS AFFECTING FEEDER CATTLE PRICE DIFFERENTIALS (1988)

Feeder cattle prices are determined by the interaction of many factors. This study uses 1986 and 1987 Kansas feeder cattle auction data to investigate the impact of a wide variety of physical characteristics, many of which have not been used in previous studies on feeder cattle prices. Unlike previous studies, this analysis explicitly incorporates changes in feeder cattle market fundamentals during the data collection period and also allows price differentials to vary by sex and weight. Weight, weight-squared, lot size, lot size-squared, health, muscling, frame size, condition, fill, breed, presence of horns, and time of sale are significant factors affecting feeder cattle prices on any given day. Several physical traits also exhibit different seasonal price impacts.
Tribological phenomena at the head–disk interface of thin-film rigid disks (1989)

The stiction/friction and contact start/stop tests of thin-film rigid disks were studied. The frictional phenomena observed in a variety of tests are correlated with the surface texturization, lubricant characteristics, and overcoat material. Among other issues, replenishment of lubricant, characterization of lubricant adhesion to surface of the disk, and the compatibility of lubricant with carbon overcoat are addressed. These experimental results showed clearly the highly interacting nature of the head–disk interface phenomena.
58.1: <i>Invited Paper</i> : Views on the Present and Future Promise of OLED Displays (2006)

Abstract Although OLED performance has been explained quasi‐quantitatively by using a radar chart analysis, there are few reports of actual quantitative evaluation results. We quantitatively evaluated OLED optical and electrical characteristics and compared them with LCD and CRT performance. OLED optical characteristics are superior to those of LCDs. Furthermore, problems related to OLEDs are discussed in terms of light emitting materials, device structure, and panel components.
Cardiac First-Pass and Myocardial Perfusion in Normal Subjects Assessed by Subsecond Gd-DTPA Enhanced MR Imaging (1991)

To evaluate first pass in the right ventricular (RV) and left ventricular (LV) cavities and myocardial perfusion, subsecond MR imaging was performed in seven normal subjects following intravenous bolus injection of Gd-DTPA. After the baseline scans, sequential ECG-triggered images were obtained every three to four RR intervals. The procedure consisted of an initial presaturation pulse (150 degrees), and the acquisition time for one image was approximately 500 ms with 64 phase-encoding steps. After bolus administration of Gd-DTPA (0.05 mmol/kg body wt), progressively increasing signal intensities were observed in the RV cavity, the LV cavity, and the myocardial wall. Gadolinium DTPA enhanced subsecond MR offers temporal information of the first transit in the cardiac chambers and may provide useful clinical reference data for assessment of myocardial perfusion in patients with coronary artery disease.
Synthesis and antitumor activity of .alpha.- and .beta.-2'-deoxy-6-selenoguanosine and certain related derivatives (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antitumor activity of .alpha.- and .beta.-2'-deoxy-6-selenoguanosine and certain related derivativesGeorge H. Milne and Leroy B. TownsendCite this: J. Med. Chem. 1974, 17, 3, 263–268Publication Date (Print):March 1, 1974Publication History Published online1 May 2002Published inissue 1 March 1974https://pubs.acs.org/doi/10.1021/jm00249a002https://doi.org/10.1021/jm00249a002research-articleACS PublicationsRequest reuse permissionsArticle Views114Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts