gebhart/patrepeval huggingface dataset:
Structural Determinants of the Unusual Helix Stability of a De Novo Engineered Vascular Endothelial Growth Factor (VEGF) Mimicking Peptide (2008)

Helix stability: Understanding helix stability and formation is a prerequisite to elucidate the mechanism of protein folding and design helix peptides with specific activity. Herein, we analyze the thermal behaviour of a designed, α-helical, bioactive peptide, composed only of natural amino acids. This peptide shows an unusual thermal stability, in which the N-terminal region and a hydrophobic interaction play a major role (see figure). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2111/2008/z800180_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Genetic and Physiological Effects of Noncoherent Visible Light Combined with Hydrogen Peroxide on <i>Streptococcus mutans</i> in Biofilm (2008)

Oral biofilms are associated with the most common infections of the oral cavity. Bacteria embedded in the biofilms are less sensitive to antibacterial agents than planktonic bacteria are. Recently, an antibacterial synergic effect of noncoherent blue light and hydrogen peroxide (H(2)O(2)) on planktonic Streptococcus mutans was demonstrated. In this study, we tested the effect of a combination of light and H(2)O(2) on the vitality and gene expression of S. mutans embedded in biofilm. Biofilms of S. mutans were exposed to visible light (wavelengths, 400 to 500 nm) for 30 or 60 s (equivalent to 34 or 68 J/cm(2)) in the presence of 3 to 300 mM H(2)O(2). The antibacterial effect was assessed by microbial counts of each treated sample compared with that of the control. The effect of light combined with H(2)O(2) on the different layers of the biofilm was evaluated by confocal laser scanning microscopy. Gene expression was determined by real-time reverse transcription-PCR. Our results show that noncoherent light, in combination with H(2)O(2), has a synergistic antibacterial effect through all of the layers of the biofilm. Furthermore, this treatment was more effective against bacteria in biofilm than against planktonic bacteria. The combined light and H(2)O(2) treatment up-regulated the expression of several genes such as gtfB, brp, smu630, and comDE but did not affect relA and ftf. The ability of noncoherent visible light in combination with H(2)O(2) to affect bacteria in deep layers of the biofilm suggests that this treatment may be applied in biofilm-related diseases as a minimally invasive antibacterial procedure.
Interaction of Complement Factor H and Fibulin3 in Age-Related Macular Degeneration (2013)

Age-related macular degeneration (AMD) is a major cause of vision loss. It is associated with development of characteristic plaque-like deposits (soft drusen) in Bruch's membrane basal to the retinal pigment epithelium (RPE). A sequence variant (Y402H) in short consensus repeat domain 7 (SCR7) of complement factor H (CFH) is associated with risk for "dry" AMD. We asked whether the eye-targeting of this disease might be related to specific interactions of CFH SCR7 with proteins expressed in the aging human RPE/choroid that could contribute to protein deposition in drusen. Yeast 2-hybrid (Y2H) screens of a retinal pigment epithelium/choroid library derived from aged donors using CFH SCR7 baits detected an interaction with EFEMP1/Fibulin 3 (Fib3), which is the locus for an inherited macular degeneration and also accumulates basal to macular RPE in AMD. The CFH/Fib3 interaction was validated by co-immunoprecipitation of native proteins. Quantitative Y2H and ELISA assays with different recombinant protein constructs both demonstrated higher affinity for Fib3 for the disease-related CFH 402H variant. Immuno-labeling revealed colocalization of CFH and Fib3 in globular deposits within cholesterol-rich domains in soft drusen in two AMD donors homozygous for CFH 402H (H/H). This pattern of labeling was quite distinct from those seen in examples of eyes with Y/Y and H/Y genotypes. The CFH 402H/Fib3 interaction could contribute to the development of pathological aggregates in soft drusen in some patients and as such might provide a target for therapeutic intervention in some forms of AMD.
Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective (2016)

Streptococcus pneumoniae inflicts a huge disease burden as the leading cause of community-acquired pneumonia and meningitis. Soon after mainstream antibiotic usage, multiresistant pneumococcal clones emerged and disseminated worldwide. Resistant clones are generated through adaptation to antibiotic pressures imposed while naturally residing within the human upper respiratory tract. Here, a huge array of related commensal streptococcal strains transfers core genomic and accessory resistance determinants to the highly transformable pneumococcus. β-Lactam resistance is the hallmark of pneumococcal adaptability, requiring multiple independent recombination events that are traceable to nonpneumococcal origins and stably perpetuated in multiresistant clonal complexes. Pneumococcal strains with elevated MICs of β-lactams are most often resistant to additional antibiotics. Basic underlying mechanisms of most pneumococcal resistances have been identified, although new insights that increase our understanding are continually provided. Although all pneumococcal infections can be successfully treated with antibiotics, the available choices are limited for some strains. Invasive pneumococcal disease data compiled during 1998 to 2013 through the population-based Active Bacterial Core surveillance program (U.S. population base of 30,600,000) demonstrate that targeting prevalent capsular serotypes with conjugate vaccines (7-valent and 13-valent vaccines implemented in 2000 and 2010, respectively) is extremely effective in reducing resistant infections. Nonetheless, resistant non-vaccine-serotype clones continue to emerge and expand.
<title>Perceptions of crosstalk and the possibility of a zoneless autostereoscopic display</title> (2001)

Overlaid stereo image pairs, viewed without stereo demultiplexing optics, are not always perceived as a ghosted image: if image generation and display parameters are adjusted so that disparities are small and limited to foreground and background regions, then the perception is rather more of blurring than of doubling. Since this blurring seems natural, comparable to the blurring due to depth-of-focus, it is unobjectionable. In contrast, the perception of ghosting seems always to be objectionable. Now consider the possibility that there is a perceptual regime in which disparity is small enough that perception of crosstalk is as blurring rather than as ghosting, but it is large enough to stimulate depth perception. If such a perceptual region exists, then it might be exploited to relax the strict 'crosstalk minimization' requirement normally imposed in the engineering of stereoscopic displays. This paper reports experiments that indicate that such a perceptual region does actually exist. We suggest a stereoscopic display engineering design concept that illustrates how this observation might be exploited to create a zoneless autostereoscopic display. By way of introduction and motivation, we begin from the observation that, just as color can be shouted in primary tones or whispered in soft pastel hues, so stereo can be shoved in your face or raised ever so gently off the screen plane. We review the problems with 'in your face stereo,' we demonstrate that 'just enough reality' is both gentle and effective in achieving stereoscopy's fundamental goal: resolving the front-back ambiguity inherent in 2D projections, and we show how this perspective leads naturally to the relaxation of the requirement for crosstalk reduction to be the main engineering constraint on the design of stereoscopic display systems.
Photosensitised dissociation of water using dispersed suspensions of n-type semiconductors (1982)

n-Type semiconductor powders (TiO2 and SrTiO3) were used to sensitise the photochemical cleavage of water using u.v. light (λ < 400 nm) under conditions of room temperature and pressure. Although several methods of platinising these powders were used, one method in particular (involving precipitation of a platinum sol, by addition of an inert electrolyte, in the presence of the semiconductor powder) was found to produce an efficient photocatalyst for water reduction. Many different photocatalysts were tested for water reduction activity, using EDTA as an electron donor, and for water oxidation activity, using Fe3+ as an electron acceptor. In the absence of EDTA and Fe3+, u.v. irradiation of these photocatalysts liberated H2 but O2 evolution was not observed. Reasons for these observations are discussed.
Large signal stability criteria for distributed systems with constant power loads (2002)

Design oriented criteria are developed for distributed power systems with constant power loads to guarantee stability during large disturbances. The criteria place design constraints on the input filter parameters, such as the Q factor, and constraints on the amount of "ideal" constant power load that a system can support. The criteria are based on Lyapunov stability theory, mixed potential functions, and the existence of equilibrium points. The analytical criteria are validated by means of computer simulations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Opportunities and Challenges of Application-Power Control in the Age of Dark Silicon (2012)

In the age of dark silicon on-chip power control is a necessity. Upcoming and state of the art embedded- and cloud computer system-on-chips (SoCs) already provide interfaces for fine grained power control. Sometimes both: core- and interconnect-voltage and frequency can be scaled for example. To further reduce power consumption SoCs often have specialized accelerators. Due to the rising specialization of hard- and software general purpose oper- ating systems require changes to exploit the power saving opportunities provided by the hardware. However, they lack detailed hardware- and application-level-information. Application-level power control in turn is still very uncommon and diffi cult to realize. Now a days vendors of mobile devices are forced to tweak and patch system-level software to enhance the power effi ciency of each individual product. This manual process is time consuming and must be re- iterated for each new product. In this paper we explore the opportunities and challenges of automatic application-level power control using compilers.
Orobanche resistance in sunflower (2008)

This report presents the current knowledge of Orobanche resistance in sunflower from the breeder's standpoint and from the biochemists' standpoint.
Penalized Gaussian Mixture Model for the Analysis of Microarray Gene Expression Data (2009)

The diagnosis of cancer type based on gene expression profile is an important application field of DNA microarrays.In this paper,A penalized Gaussian mixture model is proposed by an L1 penalty,which makes a good conjunction with cancer diagnosis and gene selection,achieve better accuracy by less variable deal.Some theoretic analysis is given for a simple but clear explanation about the model in detail.Simulate and real data examples show that the proposed method not only have high classification accuracy but also enjoy stable performance in various cases.
Tyrosine kinase activity in <i>Pseudomonas</i> aeruginosa (1994)

Previous evidence showed that b- and a-type flagellins of Pseudomonas aeruginosa are modified in vivo by phosphorylation at tyrosine. This research was designed to demonstrate phosphorylation of flagellin at tyrosine in vitro. Evidence presented showed that flagellin is labelled by [gamma-32P]-ATP, but not by [alpha-32P]-ATP, when incubated with cell envelope fractions. Results suggested that autophosphorylation of a 42 kDa membrane protein occurred. No activity was detected in cytoplasmic fractions. Flagellin protein was identified by flagella-specific monoclonal antibody (mAb) and was labelled with anti-phosphotyrosine mAb. Confirmation of tyrosine kinase activity was shown by labelling of synthetic poly(Glu:Tyr) as a substrate with [gamma-32P]-ATP. Labelling of poly(Glu:Tyr) was heat sensitive and time dependent. Labelled phosphotyrosine was observed in partial acid hydrolysates of substrates. Using poly(Glu:Tyr) as substrate, tyrosine kinase activity was shown to be inhibited by sulphydryl reagents. It appears that tyrosine kinase and flagellin phosphorylation occur in several Pseudomonas spp. Location of phosphotyrosine in a conserved region of flagellin may serve as a cell signal so that intact flagellin is appropriately exported.
[Obesity in the elderly and very elderly--prognostic significance and practical conclusions]. (1994)

Epidemiological work on the age-dependency of the relation between overweight and mortality confirms an opinion which is traditional among physicians and has it roots in a mixture of biological understanding and common sense. The data base can be summarized in three points: 1) Up to the age of 60-65 years, overweight is combined with decreased life expectancy. The excess mortality is found mainly in the cardiovascular area and can be explained by the well-known risk factors of atherosclerosis. In the Framingham-study, overweight per se is a risk factor for this group of diagnoses. 2) In the age group 65-74 years, the relation between overweight and excess mortality vanishes gradually; the right arm of the U- or J-curve levels off. The optimal BMI moves to the right, and the right arm of the curve is shortened. 3) In high age, from 75-80 years on, overweight coincides with improved prognosis. The geriatric literature is in agreement in the sense that overweight is no problem in high age.
Metal-free syn-dioxygenation of alkenes (2013)

Reactions employing inexpensive reagents from sustainable sources and with low toxicity are becoming increasingly desirable from an academic and industrial perspective. A fascinating example of a synthetic transformation that requires development of alternative procedures is the osmium catalysed dihydroxylation. Recently there has been considerable interest in achieving this reaction through metal-free procedures. This review describes the methods available for metal-free syn-dioxygenation of alkenes.
ARCHAEOLOGY AND THE BIBLE—(INTRODUCTORY) (1937)

ARCHAEOLOGY AND THE BIBLE—(INTRODUCTORY) J. W. FLIGHT J. W. FLIGHT PROF. Haverford College Search for other works by this author on: Oxford Academic Google Scholar Journal of the American Academy of Religion, Volume V, Issue I, January 1937, Pages 30–32, https://doi.org/10.1093/jaarel/V.I.30 Published: 01 January 1937
Spectrally-shaped correlation with application to image registration (2019)

Image correlation has proven useful for image filtering, matching, pattern recognition, and image registration over many decades. The two classical correlation forms, amplitude and phase correlation, display different properties. Amplitude correlation often provides a low, broad peak in the correlation domain. The broadness of the peak provides robustness to matching imagery exhibiting non-translational geometric offsets, such as rotation or scale differences. By contrast, phase correlation tends to provide a high, narrow peak. The high peak signifies high matching confidence while the narrow peak width provides accurate shift localization. However, the phase correlation peak degrades rapidly when matching against images with non-translational geometric offset. To provide tradeoffs between properties of these traditional correlation forms, in this paper we present a general, flexible form of correlation called Spectrally-Shaped Correlation (SSC). SSC provides control over the Fourier domain normalization of the correlation components. We apply SSC to the problem of image registration. We show how SSC contains the classical amplitude, phase, and phase-only correlation forms as special cases. First, we present the general theory of Fourier transforms for multi-channel imagery, modeled as hypercomplex-valued imagery. We present mathematical details of the transform techniques and develop the SSC approach. We then present numerical results demonstrating registration of real image data, acquired from a UAV operating in an urban environment, to reference imagery. We demonstrate a performance improvement of the SSC over the classical forms of correlation.
Metadherin Mediates Lipopolysaccharide-Induced Migration and Invasion of Breast Cancer Cells (2011)

These results strongly suggest that MTDH is a pivotal molecule in inflammation-mediated tumor metastasis. Since NF-κB, IL-8 and MMP-9 play roles in LPS-induced invasion or metastasis, the mechanism of MTDH-promoted invasion and metastasis may be through the activation of NF-κB, IL-8 and MMP-9, also suggesting a role of MTDH in regulating both inflammatory responses and inflammation-associated tumor invasion. These findings indicate that MTDH is involved in inflammation-induced tumor progression, and support that MTDH targeting therapy may hold promising prospects in treating breast cancer.
Capicua DNA-binding sites are general response elements for RTK signaling in<i>Drosophila</i> (2011)

RTK/Ras/MAPK signaling pathways play key functions in metazoan development, but how they control expression of downstream genes is not well understood. In Drosophila, it is generally assumed that most transcriptional responses to RTK signal activation depend on binding of Ets-family proteins to specific cis-acting sites in target enhancers. Here, we show that several Drosophila RTK pathways control expression of downstream genes through common octameric elements that are binding sites for the HMG-box factor Capicua, a transcriptional repressor that is downregulated by RTK signaling in different contexts. We show that Torso RTK-dependent regulation of terminal gap gene expression in the early embryo critically depends on Capicua octameric sites, and that binding of Capicua to these sites is essential for recruitment of the Groucho co-repressor to the huckebein enhancer in vivo. We then show that subsequent activation of the EGFR RTK pathway in the neuroectodermal region of the embryo controls dorsal-ventral gene expression by downregulating the Capicua protein, and that this control also depends on Capicua octameric motifs. Thus, a similar mechanism of RTK regulation operates during subdivision of the anterior-posterior and dorsal-ventral embryonic axes. We also find that identical DNA octamers mediate Capicua-dependent regulation of another EGFR target in the developing wing. Remarkably, a simple combination of activator-binding sites and Capicua motifs is sufficient to establish complex patterns of gene expression in response to both Torso and EGFR activation in different tissues. We conclude that Capicua octamers are general response elements for RTK signaling in Drosophila.
Pararectal Cystotomy for Urolith Removal in Nine Horses (2010)

Pararectal cystotomy allows removal of cystic calculi in standing sedated horses. The technique may offer an economic advantage over approaches that require general anesthesia.
Relationship between ω3 long‐chain polyunsaturated fatty acid status during early infancy and neurodevelopmental status at 1 year of age (2002)

These statistically significant correlations suggest that the omega3 fatty acid status during early infancy may be important with respect to neurodevelopmental status at 1 year of age and highlight the need for further studies of this possibility.
On enzymatic activity in organic solvents as a function of enzyme history (1998)

Catalytic activities of alpha-chymotrypsin and subtilisin Carlsberg in various hydrous organic solvents were measured as a function of how the enzyme suspension had been prepared. In one method, lyophilized enzyme was directly suspended in the solvent containing 1% water. In another, the enzyme was precipitated from its aqueous solution by a 100-fold dilution with an anhydrous solvent. In most cases, the reaction rate in a given nonaqueous enzymatic system strongly (up to an order of magnitude) depended on the mode of enzyme preparation. The magnitude of this dependence was markedly affected by the nature of the solvent and enzyme. A mechanistic hypothesis proposed to explain the observed dependencies was verified in additional experiments in which the water contents and enzyme history were further varied.
Integrating GIS, simulation and animation (1991)

The author describes techniques for combining the strengths of geographical information systems (GISs), microscopic simulation, and computer animation. A simulation system integrated with an existing GIS to provide the user with the capability of accessing and managing the information transfer between the GIS and the simulation models is described. This integrated system need not be limited to simulation alone; other calculations which are essential for the traffic engineer can be integrated as well. For example, the calculation of highway capacity is a basic need of all traffic engineers. The software to perform these calculations can, itself, be integrated with the GIS system, traffic simulation, and animation. Such a system offers the engineer a capability that goes beyond analysis: the engineer can now perform designs of a system exploring alternative treatments to identify the most effective technique for improving traffic operations. >
The anti-hyperglycemic property of different ginseng partitions (2005)

Ginseng is a popular medicinal plant highly valued throughout the world. Asian ginseng is one of the most common species of ginseng. It has long occupied a significant position in oriental medicine and has been justified its name as the 'king herb'. As a nutritional supplement, ginseng is an extremely common and popular herbal medicine in the United States and Canada in recent decades. The multiple constituents of ginseng possess equally multifaceted pharmacological actions as demonstrated by numerous studies. Ginseng root and its constituents influenced the central nervous system, endocrine, cardiovascular, gastrointestinal system, sexual, renal organ and immune system, etc. One important action is its anti-hyperglycemic effect. Previous studies on ginseng demonstrate that only the root of ginseng has been used in the treatment of diabetes, while the other parts of ginseng plant were always neglected. Recently, we analyzed the constituents of ginseng berry, leaf and discovered that ginseng berry, leaf extracts and its total ginsenosides have the ability to reduce hyperglycemia and body weight and increase the peripheral glucose utilization in obese or diabetic ob/ob or db/db mice. Our data suggest that all parts of ginseng plant, including root, berry, leaf and stem exhibit potent anti-hyperglycemic and anti-obese effects and may provide an opportunity to develop a novel class of anti-diabetic agents.
Double-Blind, Randomized Trial Comparing the Efficacy and Tolerability of Fulvestrant Versus Anastrozole in Postmenopausal Women With Advanced Breast Cancer Progressing on Prior Endocrine Therapy: Results of a North American Trial (2002)

Fulvestrant was at least as effective as anastrozole, with efficacy end points slightly favoring fulvestrant. Fulvestrant represents an additional treatment option for postmenopausal women with advanced breast cancer whose disease progresses on tamoxifen therapy.