gebhart/patrepeval huggingface dataset:
On-line condition monitoring for MOSFET and IGBT switches in digitally controlled drives (2011)

The early detection of incipient faults is desirable in mission-critical applications such as shipboard propulsion drives. This paper presents an on-line condition-monitoring approach for detecting incipient faults in IGBTs and MOSFETs. The proposed algorithm extracts important device features (i.e V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CE,ON</inf> and R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS,ON</inf> ) and compares them to healthy values recorded over a range of operating conditions. The algorithm is based on principal-components analysis (PCA). An experimental implementation in an IGBT-based drive is described. An on-line feature extraction scheme for MOSFETs is also proposed and demonstrated. This scheme exploits the nature of carrier-based PWM in order simplify the measurement process.
The Synthesis and Pharmacologic Evaluation of a Series of 8-Alkylthio-Thiated Theophyllines<sup>1</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis and Pharmacologic Evaluation of a Series of 8-Alkylthio-Thiated Theophyllines1Albert J. Dietz Jr. and Raymond M. BurgisonCite this: J. Med. Chem. 1966, 9, 4, 500–506Publication Date (Print):July 1, 1966Publication History Published online1 May 2002Published inissue 1 July 1966https://pubs.acs.org/doi/10.1021/jm00322a013https://doi.org/10.1021/jm00322a013research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression (2003)

The mitotic spindle is essential for the maintenance of genetic stability, and in budding yeast its assembly and function depend on the Mps1 protein kinase. Mps1p is required for centrosome duplication and the spindle checkpoint. Several recent reports demonstrate that vertebrate Mps1 proteins regulate the spindle checkpoint, but reports conflict regarding their role in centrosome duplication. Here we provide multiple lines of evidence that the human Mps1 protein (hMps1) is required for centrosome duplication. A recently described rabbit polyclonal antibody against hMps1 specifically recognizes centrosomes in a variety of human cell types. Overexpression of a dominant-negative version of hMps1 (hMps1KD) can prevent centrosome duplication in a variety of cell types, and active hMps1 accelerates centrosome reduplication in U2OS cells. Finally, we demonstrate that disruption of hMps1 function with pools of hMps1-specific small interfering RNAs causes a pleiotropic phenotype resulting from the combination of severe mitotic abnormalities and failures in centrosome duplication. This approach demonstrates that hMps1 is required for centrosome duplication and for the normal progression of mitosis, and suggests that the threshold level of hMps1 function required for centrosome duplication is lower than that required for hMps1 mitotic functions.
Feasibility of Delivering Mesenchymal Stem Cells via Catheter to the Proximal End of the Lesion Artery in Patients with Stroke in the Territory of the Middle Cerebral Artery (2013)

Stem cell-based therapy shows great potential in stroke patients. Intra-artery infusion exhibits greater biological distribution compared to intravenous delivery. In addition, umbilical cord mesenchymal stem cells (UCMSCs) have several advantages compared with other types of stem cells. The aim of this study was to evaluate the safety and efficacy of UCMSCs delivered by a catheter to a near lesion site for treatment of an infarction in the middle cerebral artery territory. Four patients with stroke (three with ischemic and one with hemorrhagic stroke) in the middle cerebral artery territory were recruited in this study. One single dose of 2 × 10 7 UCMSCs was infused within 20 min via catheterization in the M1 segment of the middle cerebral artery. The safety and efficacy of this approach were assessed during the in-hospital and 6-month follow-up evaluation. The cell delivery was successfully performed in all of the patients, and no major accidents (stroke or death) were observed. Moreover, no fever or rash was reported. After cellular therapy, two of the three ischemic stroke patients demonstrated improved muscle strength. The improvement of the modified Rankin scale was observed in two patients, both of whom suffered from ischemic stroke at 90 and 180 days after the stem cell therapy. The hemorrhagic stroke patient failed to demonstrate improved muscle strength and did not amend his daily activities. Intra-artery delivery of UCMSCs via catheterization was a feasible and safe approach and may improve the neurological function of ischemic stroke patients with the middle cerebral artery territory infarcts.
Research and engineering assessment of biological solubilization of phosphate (1993)

This research and engineering assessment examined a microbial phosphate solubilization process as a method of recovering phosphate from phosphorus containing ore compared to the existing wet acid and electric arc methods. A total of 860 microbial isolates, collected from a range of natural environments were tested for their ability to solubilize phosphate from rock phosphate. A bacterium (Pseudomonas cepacia) was selected for extensive characterization and evaluation of the mechanism of phosphate solubilization and of process engineering parameters necessary to recover phosphate from rock phosphate. These studies found that concentration of hydrogen ion and production of organic acids arising from oxidation of the carbon source facilitated microbial solubilization of both pure chemical insoluble phosphate compounds and phosphate rock. Genetic studies found that phosphate solubilization was linked to an enzyme system (glucose dehydrogenase). Process-related studies found that a critical solids density of 1% by weight (ore to liquid) was necessary for optimal solubilization. An engineering analysis evaluated the cost and energy requirements for a 2 million ton per year sized plant, whose size was selected to be comparable to existing wet acid plants.
Solid Clusters above the Bulk Melting Point (2000)

The fact that the melting points of nanoparticles are always lower than those of the corresponding bulk material is a paradigm supported by extensive experimental data for a large number of systems and by numerous calculations. Here we demonstrate that tin cluster ions with 10-30 atoms remain solid at approximately 50 K above the melting point of bulk tin. This behavior is possibly related to the fact that the structure of the clusters is completely different from that of the bulk element.
SSDS-MC: Slice-based Secure Data Storage in Multi-Cloud Environment (2015)

With the easy access to cloud technologies and rich applications, more people tend to store their data in cloud. However, the data in the cloud have to face the privacy and security challenges. To enforce the privacy and security protection of data in the cloud, Slice-based Secure Data Storage in Mu
Control of bat wing capillary pressure and blood flow during reduced perfusion pressure (1988)

Regulation of blood flow depends on changes in the sum of arterial (Ra) and venous (Rv) resistances, whereas regulation of capillary pressure (Pc) depends on the ratio of Rv to Ra. If the myogenic response of the arterial system (i.e., delta Ra) is the primary mechanism for controlling pressure and flow when perfusion pressure is lowered, then Pc and total flow should be regulated to the same degree under these conditions. This hypothesis was tested by making direct measurements of Pc and flow in skin and skeletal muscle in the wings of unanesthetized bats. The box method was used to reduce perfusion pressure to the wing. Pressures were measured with a servo-null system; flows were computed from measurements of vascular diameters and red cell velocities using intravital microscopy. All branching orders of arterioles dilated significantly during decreases in box pressure (Pb). For 0 less than Pb less than or equal to -30 mmHg, total flow (1st-order arteriolar flow) remained nearly constant, whereas Pc was "regulated" only approximately 60%. These results cannot be explained by changes in arteriolar resistance alone and suggest that changes in Rv may be important. The possible consequences of flow redistribution, capillary recruitment, and micropressure sampling procedures are discussed in relationship to local regulation of capillary pressure and flow.
Applications of Animal Biosensors: A Review (2014)

Odorous compounds perceived by humans or animal species produce a response in chemical- or electronic-based analytical detection systems (chemical sensors, electronic noses, gas chromatography, mass spectrometers, and so on). Animal noses can also produce a recognizable behavioral response in the animal, when exposed to those compounds. Recently, much attention has been paid to the use of animals for scent detection based on their behavioral responses, referred to as animal biosensors. So far, behavioral odor detection by animals has been applicable in some fields, such as forensic sciences, homeland security, or, more recently, cancer diagnostics. The major advantage of animal biosensors is that the animals can be conditioned rapidly and cost-effectively, offering benefits in terms of noninvasive detection and early diagnosis. Here, we review the applications of living biosensors as whole animal biosensors and discuss the main issues, approaches, and challenges.
Motion planning for steep hill climbing (2011)

The motors or engines of an autonomous ground vehicles (AGV) have torque and power limitations, which limit their abilities to climb steep hills, which are defined to be hills that have high grade sections in which the vehicle is forced to decelerate. Traversal of a steep hill requires the vehicle to have sufficient momentum before entering the hill. This problem is part of a larger class of momentum-based motion planning problems such as the problem of lifting heavy objects with manipulators. Hence, solutions to the steep hill climbing problem have much wider applicability. The motion planning here is accomplished using a dynamic model of the skid-steered AGV used in the experiments along with Sampling Based Model Predictive Control (SBMPC), a recently developed input sampling planning algorithm that may be viewed as a generalization of LPA* to the direct use of kinodynamic models. The motion planning is demonstrated experimentally using two scenarios, one in which the robot starts at rest at the bottom of a hill and one in which the robot starts at rest a distance from the hill. The first scenario requires the AGV to first reverse direction so that the vehicle can gather enough momentum before reaching the hill. This corresponds to having the vehicle begin at a local minimum, which results in a problem that many traditional model predictive control methods cannot solve. It is seen that, whereas open loop trajectories can lead to vehicle immobilization, SBMPC successfully uses the information provided by the dynamic model to ensure that the AGV has the requisite momentum.
Murine animal models for preclinical islet transplantation (2013)

Advances in islet transplantation research have led to remarkable improvements in the outcome in humans with type 1 diabetes. However, pitfalls, mainly linked both to early liver-specific inflammatory events and to pre-existing and transplant-induced auto- and allo-specific adaptive immune responses, still remain. In this scenario research into pancreatic islet transplantation, essential to investigate new strategies to overcome open issues, needs very well-designed preclinical studies to obtain consistent and reliable results and select only promising strategies that may be translated into the clinical practice. This review discusses the main shortcomings of the mouse models currently used in islet transplantation research, outlining the main factors and variables to take into account for the design of new preclinical studies. Since several parameters concerning both the graft (i.e., islets) and the recipient (i.e., diabetic mice) may influence transplant outcome, we recommend considering several critical points in designing future bench-to-bedside islet transplantation research.
A unified approach for hybrid source localization based on ranges and video (2015)

This paper presents a hybrid method for single-source localization in wireless sensor networks, fusing noisy range measurements with angular information extracted from video. Although recent works found in the literature explore hybrid schemes, these include several cumbersome assumptions. We develop and test, both numerically and experimentally, a hybrid localization algorithm which surpasses the limitations of previous fusing approaches. The proposed method (FLORIS) is based on a nonconvex least-squares joint formulation, for which a tight convex relaxation is applied to obtain a semidefinite program. Numerical simulations show that FLORIS has comparable performance to state-of-the-art methods, even outperforming them in some scenarios. Real experiments show that FLORIS is feasible in practical application scenarios, achieving very good accuracy and robustness. Importantly, coverage requirements for the infrastructure in a given area are more flexible than resorting to a single type of sensor, which may simplify practical deployments.
Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins (2014)

Tight junctions (TJs) are dynamic, multiprotein intercellular adhesive contacts that provide a vital barrier function in epithelial tissues. TJs are remodeled during physiological development and pathological mucosal inflammation, and differential expression of the claudin family of TJ proteins determines epithelial barrier properties. However, the molecular mechanisms involved in TJ remodeling are incompletely understood. Using acGFP-claudin 4 as a biosensor of TJ remodeling, we observed increased claudin 4 fluorescence recovery after photobleaching (FRAP) dynamics in response to inflammatory cytokines. Interferon γ and tumor necrosis factor α increased the proportion of mobile claudin 4 in the TJ. Up-regulation of claudin 4 protein rescued these mobility defects and cytokine-induced barrier compromise. Furthermore, claudins 2 and 4 have reciprocal effects on epithelial barrier function, exhibit differential FRAP dynamics, and compete for residency within the TJ. These findings establish a model of TJs as self-assembling systems that undergo remodeling in response to proinflammatory cytokines through a mechanism of heterotypic claudin-binding incompatibility.
Single-Electrode-Based Sliding Triboelectric Nanogenerator for Self-Powered Displacement Vector Sensor System (2013)

We report a single-electrode-based sliding-mode triboelectric nanogenerator (TENG) that not only can harvest mechanical energy but also is a self-powered displacement vector sensor system for touching pad technology. By utilizing the relative sliding between an electrodeless polytetrafluoroethylene (PTFE) patch with surface-etched nanoparticles and an Al electrode that is grounded, the fabricated TENG can produce an open-circuit voltage up to 1100 V, a short-circuit current density of 6 mA/m(2), and a maximum power density of 350 mW/m(2) on a load of 100 MΩ, which can be used to instantaneously drive 100 green-light-emitting diodes (LEDs). The working mechanism of the TENG is based on the charge transfer between the Al electrode and the ground by modulating the relative sliding distance between the tribo-charged PTFE patch and the Al plate. Grating of linear rows on the Al electrode enables the detection of the sliding speed of the PTFE patch along one direction. Moreover, we demonstrated that 16 Al electrode channels arranged along four directions were used to monitor the displacement (the direction and the location) of the PTFE patch at the center, where the output voltage signals in the 16 channels were recorded in real-time to form a mapping figure. The advantage of this design is that it only requires the bottom Al electrode to be grounded and the top PTFE patch needs no electrical contact, which is beneficial for energy harvesting in automobile rotation mode and touch pad applications.
A miniature continuous adiabatic demagnetization refrigerator with compact shielded superconducting magnets (2004)

Cryogenic detectors for astrophysics depend on cryocoolers capable of achieving temperatures below ~ 100 mK. In order to provide continuous cooling at 50 mK for space or laboratory applications, we are designing a miniature adiabatic demagnetization refrigerator (MADR) anchored at a reservoir at 5 K. Continuous cooling is obtained by the use of several paramagnetic pills placed in series with heat switches. All operations are fully electronic and this technology can be adapted fairly easily for a wide range of temperatures and cooling powers. We are focusing on reducing the size and mass of the cooler. For that purpose we have developed and tested magnetoresistive heat switches based on single crystals of tungsten. Several superconducting magnets are required for this cooler and we have designed and manufactured compact magnets. A special focus has been put on the reduction of parasitic magnetic fields in the cold stage, while minimizing the mass of the shields. A prototype continuous MADR, using magnetoresistive heat switches, small paramagnetic pills and compact magnets has been tested. A design of MADR that will provide ~ 5 uW of continuous cooling down to 50 mK is described.
Optimal use of the Ommaya reservoir in clinical oncology. (1989)

A major obstacle to the effective systemic therapy of intracranial malignancies and infections, the bloodbrain barrier was overcome by the development of the Ommaya reservoir in 1963. Initially used in treating cryptococcal meningitis, this closed system for continued access to the ventricular spaces has a variety of applications. They include treatment of cancer pain, chronic or recurrent CNS infection, prophylaxis of CNS involvement in acute lymphoblastic leukemia, and treatment of leptomeningeal malignancy. The authors outline the rationale, latest indications, surgical technique, and potential complications arising from the use of the Ommaya reservoir and other such subcutaneous reservoirs.
Integrated-optic polarisation convertor on (001)-InP substrate (1986)

A novel TE/TM convertor is proposed and demonstrated which is fabricated on (001)-InP substrate and can be integrated with TE-TM phase shifters to provide a general polarisation transformation. Some aspects of the technological realisation and first results are given; in a first attempt, a polarisation rotation of about 20 deg by 20 V could be demonstrated.
Lamination of ultra-thin silicon wafers for producing high-quality and low-cost x-ray telescope mirrors (2017)

We present a thin wafer lamination method for producing X-ray telescope mirrors aiming at 1-10’’ optics quality and low fabrication cost. Traditional grinding/polishing and hot slumping methods find difficulty to meet the required figure accuracy when the mirror thickness is below 1 mm. In this paper, we introduce a new fabrication procedure to satisfy those requirements: first, we laminate flat and ultra-thin silicon wafers on a well polished mandrel via direct bonding until the wafer stack achieves the designed thickness. Second, we release the stack from the mandrel since the direct bonding is temporary. Third, we anneal the stack to create permanent bonding and stabilize the deformation. In such a manner, the intrinsic waviness of each wafer can be alleviated. Our FEA simulation shows the RMS slope error of the stack surface released from a flat mandrel is improved by a factor of 6 when the layer number is doubled, regardless of the total thickness. In the case of a cylindrical mandrel, the local waviness could be improved by a factor of 4000, while a cone angle problem appears and needs to be resolved in future work. We also developed the fabrication method and successfully optimized our wafer cleaning process.
Paralysis and growth of the musculoskeletal system in the embryonic chick (1990)

Avian embryos can be completely paralyzed by injection of neuromuscular-blocking agents. We used a single injection of decamethonium iodide to paralyze embryos at 7, 8, or 10 days of incubation and analyzed the growth of individual bones (clavicle, mandible, ulna, femur, tibia, humerus) and of individual muscles that act upon some of those bones (clavicular and sternal heads of m. pectoralis, and mm. biceps brachii, depressor mandibulae, pseudotemporalis, and adductor externus). Growth of the bones is not equally affected by paralysis. Only 27% of clavicular growth (by mass) but 77% of mandibular growth occurred in paralyzed embryos, whereas the four long bones exhibited 52-63% of their normal growth. Analysis of muscle weight, fiber length and physiological cross-sectional area (weight/fiber length) indicate that there was greater reduction of the muscles acting on the limbs than of those acting on the mandible, i.e., diminished growth of the skeleton is correlated with reduced muscular activity. Specific retardation of clavicular growth is due to fusion of sternal rudiments and collapse of the thorax, as well as virtual absence of the musculature that normally attaches to the clavicle. We discuss these results in the light of intrinsic and extrinsic factors governing growth of the embryonic skeleton. Paralysis reduces skeletal growth by reducing both the movements taking place in ovo, and the loads imposed on the bones by muscle contraction, changes that represent alterations in the mechanical environment of the skeleton.