gebhart/patrepeval huggingface dataset:
Retention in capillary supercritical fluid chromatography (1985)

Abstract Supercritical fluid chromatography (SFC) sometimes exhibits GC‐like behavior and sometimes LC‐like behavior, depending on conditions. However, it is not always clear whether one of these types of behavior, or a combination, operates for a particular set of conditions for every solute in a mixture. For example, some components may be partitioned mostly by their vapor pressures, while others, in the same mixture, are partitioned predominantly by solvent‐like properties of the mobile phase. Plots of retetion (as log of the capacity factor) vs . reciprocal temperature at constant pressure reveal a clear change in the character of the separation of well‐behaved solutes. A thermodynamic explanation of the observed behavior is given, based on the assumption that partitioning is controlled by the heats of solution of solute in the mobile and stationary phases. A model of SFC retention as it deviates from pure‐GC behavior on the same column is presented.
Survey of Dairy Management Practices on One Hundred Thirteen North Central and Northeastern United States Dairies (2008)

The objective was to conduct a broad survey of dairy management practices that have an effect on animal well-being. Dairies were visited during the fall and winter of 2005 and 2006 in Wisconsin, Minnesota, Indiana, Iowa, and New York. Data were collected on 113 dairies on colostrum feeding, dehorning, tail-docking, euthanasia methods, producer statements about welfare, use of specialized calf-raising farms (custom), level of satisfaction with calf-raising by producers, and cow behavior. Calves were raised by the owner on 50.4% of dairies; 30.1% were raised on custom farms during the milk-feeding period, 18.6% were custom raised after weaning, and 1% sold calves with the option to buy them back as first-lactation heifers. A total of 51.8% of producers were very satisfied with their current calf-raising methods. Three feedings of colostrum were fed to the calves on 23.9% of dairies, 2 feedings on 39.8% of farms, 1 feeding on 31.0% of farms, and colostrum replacement products were fed on 5.3% of farms. Many farms (61.9%) provided 3.8 L at first feeding. Calves were dehorned at different ages by various methods. By 8 wk, 34.5% of calves were dehorned. By 12 wk, 78.8% of calves were dehorned. The majority of calves were dehorned by hot iron (67.3%). The remainder were dehorned by gouging (8.8%), paste (9.7%), saw (3.5%), or unknown by calf owner (10.6%). Anesthetic use was reported by 12.4% of dairy owners and analgesia use by 1.8%. Tail-docking was observed on 82.3% of dairies. The most common reported docking time was pre- or postcalving (35.2%). The second most commonly reported time was d 1 (15.4%). Rubber band was the most common method (92.5%), followed by amputation (7.5%). Three dairies amputated precalving, 1 at 2 mo and 3 at d 1 or 2. Cow hygiene was the most common reason given to dock (73.5%), followed by parlor worker comfort (17.4%) and udder health (1.0%). Producers reported 2.0% of cows obviously lame. Gun was the preferred euthanasia method (85.7%), followed by i.v. euthanasia (8.0%), live pick-up (1.8%), and nondisclosure (3.5%). Most producers (77.9%) stated that cows were in an improved environment as compared with 20 yr ago, whereas 8.0% stated conditions were worse, and 14.2% were undecided. Dairies with higher percentages of cows that either approached or touched the observer had lower somatic cell counts. The survey results showed management practices that were important for animal welfare.
The Internet of Things Has a Gateway Problem (2015)

The vision of an Internet of Things (IoT) has captured the imagination of the world and raised billions of dollars, all before we stopped to deeply consider how all these Things should connect to the Internet. The current state-of-the-art requires application-layer gateways both in software and hardware that provide application-specific connectivity to IoT devices. In much the same way that it would be difficult to imagine requiring a new web browser for each website, it is hard to imagine our current approach to IoT connectivity scaling to support the IoT vision. The IoT gateway problem exists in part because today's gateways conflate network connectivity, in-network processing, and user interface functions. We believe that disentangling these functions would improve the connectivity potential for IoT devices. To realize the broader vision, we propose an architecture that leverages the increasingly ubiquitous presence of Bluetooth Low Energy radios to connect IoT peripherals to the Internet. In much the same way that WiFi access points revolutionized laptop utility, we envision that a worldwide deployment of IoT gateways could revolutionize application-agnostic connectivity, thus breaking free from the stove-piped architectures now taking hold. In this paper, we present our proposed architecture, show example applications enabled by it, and explore research challenges in its implementation and deployment.
Growth of textured thin Au coatings on iron oxide nanoparticles with near infrared absorbance (2012)

A homologous series of Au coated iron oxide nanoparticles with hydrodynamic diameters smaller than 60 nm was synthesized with very low Au-to-iron mass ratios, as low as 0.15. The hydrodynamic diameter was determined by dynamic light scattering and the composition by atomic absorption spectroscopy and energy dispersive x-ray spectroscopy. Unusually low Au precursor supersaturation levels were utilized to nucleate and grow Au coatings on iron oxide relative to the formation of pure Au nanoparticles. This approach produced unusually thin coatings by lowering autocatalytic growth of Au on Au, as shown by transmission electron microscopy. Nearly all of the nanoparticles were attracted by a magnet, indicating a minimal number of pure Au particles. The coatings were sufficiently thin to shift the surface plasmon resonance to the near infrared with large extinction coefficients, despite the small particle hydrodynamic diameters observed from dynamic light scattering to be less than 60 nm.
Efficient isotope-selective pulsed laser ablation loading of <sup>174</sup>Yb<sup>+</sup> ions in a surface electrode trap (2019)

We report a highly efficient loading of <sup>174</sup>Yb<sup>+</sup> ions in a surface electrode ion trap by using single pulses from a Q-switched Nd:YAG laser to ablate neutral atoms, combined with a two-photon photo-ionization process. The method is three orders of magnitude faster to load a single ion as compared to traditional resistively heated sources and can load large collections of ions in seconds. The negligible thermal load of this method enables the use of this ablation-based loading scheme in ion traps operating under cryogenic conditions.
High-Density Microarray of Small-Subunit Ribosomal DNA Probes (2002)

Ribosomal DNA sequence analysis, originally conceived as a way to provide a universal phylogeny for life forms, has proven useful in many areas of biological research. Some of the most promising applications of this approach are presently limited by the rate at which sequences can be analyzed. As a step toward overcoming this limitation, we have investigated the use of photolithography chip technology to perform sequence analyses on amplified small-subunit rRNA genes. The GeneChip (Affymetrix Corporation) contained 31,179 20-mer oligonucleotides that were complementary to a subalignment of sequences in the Ribosomal Database Project (RDP) (B. L. Maidak et al., Nucleic Acids Res. 29:173-174, 2001). The chip and standard Affymetrix software were able to correctly match small-subunit ribosomal DNA amplicons with the corresponding sequences in the RDP database for 15 of 17 bacterial species grown in pure culture. When bacteria collected from an air sample were tested, the method compared favorably with cloning and sequencing amplicons in determining the presence of phylogenetic groups. However, the method could not resolve the individual sequences comprising a complex mixed sample. Given these results and the potential for future enhancement of this technology, it may become widely useful.
NMR Structural Investigation of the Mitochondrial Outer Membrane Protein VDAC and Its Interaction with Antiapoptotic Bcl-x<sub>L</sub> (2006)

Bcl-2 family proteins are essential regulators of cell death and exert their primary pro- or antiapoptotic roles at the mitochondrial outer membrane. Previously, pro- and antiapoptotic Bcl-2 proteins have been shown to interact with the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane. VDAC is a 283-residue integral membrane protein that forms an aqueous pore in the outer mitochondrial membrane, through which metabolites and other small molecules pass between the cytosol and intermembrane space. The essential life-sustaining function of VDAC in metabolite trafficking is believed to be regulated by proteins of the Bcl-2 family. The protective role of antiapoptotic Bcl-xL may be through its interaction with VDAC. Here, VDAC has been expressed, purified, and refolded into a functional form amenable to NMR studies. Various biophysical experiments indicate that micelle-bound VDAC is in intermediate exchange between monomer and trimer. Using NMR spectroscopy, gel filtration, and chemical cross-linking, we obtained direct evidence for binding of Bcl-xL to VDAC in a detergent micelle system. The VDAC-interacting region of Bcl-xL was characterized by NMR with chemical shift perturbation and transferred cross-saturation. The interaction region was mapped to a putative helical hairpin motif of Bcl-xL that was found to insert into detergent micelles. Our results suggest that Bcl-xL can bind to one or two VDAC molecules forming heterodimers and heterotrimers. Our characterization of the VDAC/Bcl-xL complex offers initial structural insight into the role of antiapoptotic Bcl-xL in regulating apoptotic events in the mitochondrial outer membrane.
On the thermodynamics of degradation (2008)

The science base that underlies modelling and analysis of machine reliability has remained substantially unchanged for decades. Therefore, it is not surprising that a significant gap exists between available machinery technology and science to capture degradation dynamics for prediction of failure. Further, there is a lack of a systematic technique for the development of accelerated failure testing of machinery components. This article develops a thermodynamic characterization of degradation dynamics, which employs entropy, a measure of thermodynamic disorder, as the fundamental measure of degradation; this relates entropy generation to irreversible degradation and shows that components of material degradation can be related to the production of corresponding thermodynamic entropy by the irreversible dissipative processes that characterize the degradation. A theorem that relates entropy generation to irreversible degradation, via generalized thermodynamic forces and degradation forces, is constructed. This theorem provides the basis of a structured method for formulating degradation models consistent with the laws of thermodynamics. Applications of the theorem to problems involving sliding wear and fretting wear, caused by effects of friction and associated with tribological components, are presented.
Statistical Discourse Analysis of a Role-Based Online Discussion Forum: Patterns of Knowledge Construction (2012)

Assigning roles to individual students can influence the group's knowledge construction (KC) process during online discussions. Twenty-one students were divided into two groups and assigned rotating roles for eight one-week asynchronous online discussions. The KC contributions of all 252 posts in the discussion were coded using a five phase scheme and statistical discourse analysis was applied to identify segments of discussion characterized by particular aspects of KC plus "pivotal posts"--those posts which initiated new segments of discussion. Finally, the influences of assigned student roles on pivotal posts and KC were modeled. The results indicate that most online discussions had a single pivotal post separating the discussion into two distinct segments: the first dominated by a lower KC phase, the second dominated by a higher KC phase. The pivotal posts that initiated later segments were often contributed mid-discussion by students playing one of two summarizing roles (Synthesizer and Wrapper).
[Review of] Dorothy Sterling. Black Foremothers: Three Lives (1991)

Black Foremothers is a much needed book written about the lives of three important black women: Ellen Craft, Ida B. Wells and Mary Church Terrell. The author, Dorothy Sterling, is to be commended for her ability to piece together the lives of these women and present them in such an interesting manner. In the foreword, Margaret Walker states that the author is highly qualified to write biographies of black women because of her intense study of American black people for at least twenty-five years.
On the control of sulphenylations at carbon (1982)

J. S. Grossert and P. K. Dubey, J. Chem. Soc., Chem. Commun., 1982, 1183 DOI: 10.1039/C39820001183
Magnetic Field Effect on Autocatalysis:  Ag and Cu in Concentrated Nitric Acid (2006)

The partial suppression of corrosion of Ag and Cu in concentrated nitric acid solution by a magnetic field of up to 5 T was studied. The corrosion current density of these metals was found to diminish with magnetic field and rotation speed in a rotating disk electrode experiment. The suppression of corrosion is associated with removal of the catalyst HNO2 from the electrode and passivation of the electrode surface. The Lorentz force was identified as the driving force responsible for the partial suppression of corrosion. A model based on the partial areas associated with active and passive regions on Ag and Cu electrodes is introduced to explain the dependence of the current density on the applied magnetic field.
Real‐world factors affecting adherence to insulin therapy in patients with Type 1 or Type 2 diabetes mellitus: a systematic review (2013)

Adherence to insulin therapy is generally poor. Few factors or patient-perceived barriers were consistently identified as predictive for non-adherence, although findings collectively suggest that a more flexible regimen may improve adherence. Switching to a pen device and reducing patient co-payments appear to improve adherence. Further real-world studies are warranted, especially in countries other than the USA, to identify factors associated with non-adherence and enable development of strategies to improve adherence to insulin therapy.
Safety control at jnr (1978)

The number of accidents at work has dropped considerably since the highest figure in 1948, as a result of the JNR's perseverance and continuous efforts. This article describes the safety regulations to which JNR staff are subjected, and reviews the measure taken to prevent accidents at work.
Western diet changes cardiac acyl-CoA composition in obese rats: a potential role for hepatic lipogenesis (2010)

The "lipotoxic footprint" of cardiac maladaptation in diet-induced obesity is poorly defined. We investigated how manipulation of dietary lipid and carbohydrate influenced potential lipotoxic species in the failing heart. In Wistar rats, contractile dysfunction develops at 48 weeks on a high-fat/high-carbohydrate "Western" diet, but not on low-fat/high-carbohydrate or high-fat diets. Cardiac content of the lipotoxic candidates--diacylglycerol, ceramide, lipid peroxide, and long-chain acyl-CoA species--was measured at different time points by high-performance liquid chromatography and biochemical assays, as was lipogenic capacity in the heart and liver by qRT-PCR and radiometric assays. Changes in membranes fluidity were also monitored using fluorescence polarization. We report that Western feeding induced a 40% decrease in myocardial palmitoleoyl-CoA content and a similar decrease in the unsaturated-to-saturated fatty acid ratio. These changes were associated with impaired cardiac mitochondrial membrane fluidity. At the same time, hepatic lipogenic capacity was increased in animals fed Western diet (+270% fatty acid elongase activity compared with high-fat diet), while fatty acid desaturase activity decreased over time. Our findings suggest that dysregulation of lipogenesis is a significant component of heart failure in diet-induced obesity.
Complement in the Homeostatic and Ischemic Brain (2015)

The complement system is a component of the immune system involved in both recognition and response to pathogens, and it is implicated in an increasing number of homeostatic and disease processes. It is well documented that reperfusion of ischemic tissue results in complement activation and an inflammatory response that causes post-reperfusion injury. This occurs following cerebral ischemia and reperfusion and triggers secondary damage that extends beyond the initial infarcted area, an outcome that has rationalized the use of complement inhibitors as candidate therapeutics after stroke. In the central nervous system, however, recent studies have revealed that complement also has essential roles in synaptic pruning, neurogenesis, and neuronal migration. In the context of recovery after stroke, these apparent divergent functions of complement may account for findings that the protective effect of complement inhibition in the acute phase after stroke is not always maintained in the subacute and chronic phases. The development of effective stroke therapies based on modulation of the complement system will require a detailed understanding of complement-dependent processes in both early neurodegenerative events and delayed neuro-reparatory processes. Here, we review the role of complement in normal brain physiology, the events initiating complement activation after cerebral ischemia-reperfusion injury, and the contribution of complement to both injury and recovery. We also discuss how the design of future experiments may better characterize the dual role of complement in recovery after ischemic stroke.
Applied Software Engineering Education (2005)

If we are to consider evaluating the available workforce under the spectrums of time, cost, and reliability, the theoretical teaching of software engineering fundamentals is not sufficient to provide the skills and knowledge expectations of the employers. Besides the specialized knowledge, the non-technical skills such as the communication ability within the group for partitioning, assigning, and monitoring task progress are required as part of the background. However, these skills are generally omitted while teaching software engineering due to lack of time, environment, and/or resources. Since traditional lectures are lacking of practical ways of creating software, the focus of this research is to present our experiments during a client-sponsored project in an applied classroom environment at the University of Arkansas at Little Rock (UALR). Our goal is to provide not only the differences between the theoretical and practical education, but also the impact of a real client and the vital considerations and conditions taken by the development team in order to prevent failure in the project are expressed. Finally, to measure the outcome of the applied teaching and conduct future enhancements, a pre and post-knowledge assessment were conducted.
Development of a Highly Efficient Protein-secreting System in Recombinant Lactobacillus casei (2010)

The available techniques for heterologous protein secretion in Lactobacillus strains are limited. The aim of the present study was to develop an efficient protein-secretion system using recombinant lactobacilli for various applications such as live delivery of biotherapeutics. For the construction of expression vectors, the Lactobacillus brevis slpA promoter, Lactobacillus casei prtP signal sequence, and mouse IL-10 sequences were used as a model system. Interestingly, the slpA promoter exhibited strong activity in L. casei contrary to previous observations. In order to stabilize replication of the plasmid in E. coli, a removable terminator sequence was built into the promoter region. For the improvement of secretion efficiency, a DTNSD oligopeptide was added to the cleavage site of signal peptidase. The resulting plasmids provided remarkably efficient IL-10 secretion. Accumulation of the protein in the culture supernatant varied widely according to the pH conditions. By analysis of the secreted protein, formation of homodimers and biological activity, IL-10 was confirmed to be functional. The presently constructed plasmids could be useful tools for heterologous protein-secretion in L. casei.
Preventing history forgery with secure provenance (2009)

As increasing amounts of valuable information are produced and persist digitally, the ability to determine the origin of data becomes important. In science, medicine, commerce, and government, data provenance tracking is essential for rights protection, regulatory compliance, management of intelligence and medical data, and authentication of information as it flows through workplace tasks. While significant research has been conducted in this area, the associated security and privacy issues have not been explored, leaving provenance information vulnerable to illicit alteration as it passes through untrusted environments. In this article, we show how to provide strong integrity and confidentiality assurances for data provenance information at the kernel, file system, or application layer. We describe Sprov, our provenance-aware system prototype that implements provenance tracking of data writes at the application layer, which makes Sprov extremely easy to deploy. We present empirical results that show that, for real-life workloads, the runtime overhead of Sprov for recording provenance with confidentiality and integrity guarantees ranges from 1% to 13%, when all file modifications are recorded, and from 12% to 16%, when all file read and modifications are tracked.
Myoelectric Evoked Potentials Versus Locomotor Recovery in Chronic Spinal Cord Injured Rats (1993)

The purpose of this study was to determine the utility of descending evoked potentials in evaluating functional recovery in rats after spinal cord contusion injury. Rats received thoracic contusions at T9 using a controlled-displacement impactor. They were evaluated for 5 weeks postinjury using auditory startle responses (ASR) while alert, or by cerebellar motor evoked potentials (CMEP) while anesthetized. ASR and CMEP were recorded electromyographically from forelimb and hindlimb muscles. Open field locomotor performance was also assessed and recovered to almost normal levels by 3 weeks postinjury. Histologic analysis of the injury site indicated that the contusions destroyed approximately 70% of the cross-sectional area of the cord. Although the remaining 30% was sufficient to preserve nearly normal locomotor behavior, ASR and CMEP amplitudes in hindlimb flexors and extensors were reduced by 90% or more after injury and showed virtually no recovery. Significant ASR and CMEP responses were present in the cutaneous trunk muscles of the lower torso after injury. These muscles are innervated via peripheral nerves originating at cord levels above the injury. Multi-wave field potentials normally recorded from the dorsal cord surface in response to cerebellar stimulation were absent in injured rats, suggesting minimal if any activation of segmental neurons via the pathways normally mediating CMEP. The tracts mediating ASR and CMEP thus appear to be highly sensitive to mild spinal cord trauma but are evidently not essential for support or walking.
Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2 (2008)

Simvastatin has a strong anti-inflammatory effect on HPBM cells including upregulation of the atheroprotective factor KLF-2. This may partly explain the beneficial effects of statins on cardiovascular diseases.