gebhart/patrepeval huggingface dataset:
Characterization of the CCK-B/gastrin-like receptor in human colon cancer (1996)

The gastrointestinal peptide, gastrin, tonically stimulates growth of human colon cancer cells in vivo and in vitro, and does so in a receptor-mediated fashion. This study defined the nature of gastrin binding in human colon cancer using [3H]L-365,260, a specific cholecystokinin B (CCK-B)/gastrin antagonist found to block gastrin's effects on growth. Following elucidation of optimal binding conditions (e.g., pH, time, and temperature) in log phase HT-29 human colon cancer cells, specific and saturable binding with a dissociation constant of 4.8 +/- 0.7 nM and a maximal binding capacity (Bmax) of 320 +/- 120 fmol/mg protein, consistent with a single binding site, was recorded. Binding was localized to the membrane fraction. Exposure to gastrin or receptor antagonist decreased and increased, respectively, the Bmax. Competition experiments indicated that L-365,260 was 25- and 200-fold more effective at displacing radiolabeled L-365,260 than gastrin and cholecystokinin, respectively. In contrast to log phase cells, the Bmax was decreased by 67 to 76% in confluent and postconfluent cultures. Binding activity was observed in other cell lines examined, as well as in xenografts and colon cancers obtained at surgery. Binding in normal human colonic mucosa was 10-fold less than in colon cancer. These results provide the first comprehensive identification and characterization of a CCK-B/gastrin-like receptor in human colon cancer.
Further Purification and Characterization of a Circulating Antigen in Schistosomiasis (1977)

Abstract Previous studies showed that an antigen found in the circulation of animals heavily infected with Schistosoma mansoni was extracted in a trichloroacetic acid solublechloroform insoluble fraction (TCA-S-C) of adult worms. Antigenic activity was destroyed by periodate treatment but remained unaltered after treatment with proteolytic enzymes, DNase, RNase, and lyophilization. In the present study, chromatography of TCA-S-C on a DEAE cellulose column revealed six substances, one of which was antigenic. After electrophoresis in agarose antigenic activity corresponded to a slower moving, toluidine blue-staining material. A faster moving, toluidine blue-staining substance seems to be responsible for the large 260 nm. absorbing peak. Analysis of a fraction containing only antigen revealed a large amount of carbohydrate, primarily N-acetylglucosamine and d-glucuronic acid but also galactase, glucose, N-acetylglucosamine, and trace amounts of other sugars. Amino acids accounted for about 11% of the weight of the antigen. The antigen appears to be a proteoglycan.
Asian Students in the United States: Lessons That Can be Learned (1995)

This article is the result of a research review of Chinese-American students' academic performance. The key research questions are: 1) How are Asian students, especially Chinese-American students, doing academically in the United States compared with other American students? 2) How do they do well and why do they excel? 3) What are the main factors that contribute to their outstanding performance? In answering these questions, endeavours and attempts are made to explain reasons why they are doing well and to provide findings in search of factors affecting their advantages. The major purposes are to present to Singaporean and other Asian students the lessons they can learn from Chinese-American students to succeed academically and socially.
Understanding Bayesian belief networks (1989)

Although COVID-19 mRNA vaccines demonstrated high efficacy in clinical trials (1), they were not 100% efficacious. Thus, some infections postvaccination are expected. Limited data are available on effectiveness in skilled nursing facilities (SNFs) and against emerging variants. The Kentucky Department for Public Health (KDPH) and a local health department investigated a COVID-19 outbreak in a SNF that occurred after all residents and health care personnel (HCP) had been offered vaccination. Among 83 residents and 116 HCP, 75 (90.4%) and 61 (52.6%), respectively, received 2 vaccine doses. Twenty-six residents and 20 HCP received positive test results for SARS-CoV-2, the virus that causes COVID-19, including 18 residents and four HCP who had received their second vaccine dose >14 days before the outbreak began. An R.1 lineage variant was detected with whole genome sequencing (WGS). Although the R.1 variant has multiple spike protein mutations, vaccinated residents and HCP were 87% less likely to have symptomatic COVID-19 compared with those who were unvaccinated. Vaccination of SNF populations, including HCP, is critical to reduce the risk for SARS-CoV-2 introduction, transmission, and severe outcomes in SNFs. An ongoing focus on infection prevention and control practices is also essential.
ACTH‐Suppressive and Vasodilator Actions of Adrenomedullin in Conscious Sheep (1995)

Abstract Adrenomedullin (ADM) is a 52 amino‐acid peptide which is a potent vasodilator in rats, and suppresses basal and CRF‐induced ACTH release from cultured pituitary cells. The present study examines the hemodynamic and hormonal actions of human ADM (1–52) infusion in conscious, chronically instrumented sheep. Five sheep were infused intravenously (IV) or intracerebroventricularly (ICV) with ADM at 100 pg/h for 60 min, and mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), stroke volume (SV), total peripheral conductance (TPC), coronary blood flow (CF), coronary conductance (CC), peak aortic flow (Fmax), and left ventricular dF/dt were monitored by a computer‐based data collection system every 2 min. Plasma concentrations of adrenocorticotropin (ACTH), arginine vasopressin (AVP) and renin were measured after 60 min of infusion. IV ADM produced a small fall in MAP of 3 ± 1 mmHg, associated with a reflex increase in HR of 14 ± 3 b/min. CO increased by 1.3 ± 0.3 1/min, whereas SV remained unchanged. TPC was markedly increased by 20 ± 3 ml/min/mmHg. Changes in CF were also seen with an increase of 10 ± 2ml/min, and CC increased in parallel by 0.15 ± 0.02 ml/min/mmHg. Fmax and dF/dt showed small increases of 2.1 ± 0.5 Vmin and 85 ± 20 1/min/sec respectively. Plasma concentrations of ACTH and cortisol were reduced by 58% and 55% respectively, whereas plasma renin concentration increased by 106%. There was no change in plasma levels of AVP. ICV infusion of ADM had no effect on any parameter measured. These data suggest that systemic ADM produces a sustained vasodilator action to lower blood pressure in sheep, and this is the first study to report the ACTH‐suppressor action of ADM in conscious animals. ADM may therefore be an important hormone involved in the regulation of pituitary/adrenal function, in addition to its cardiovascular and fluid regulatory actions in mammals.
Simplifying the<i>H</i>∞ theory via loop-shifting, matrix-pencil and descriptor concepts (1989)

The 2-Riccati H∞ controller formulae and derivations are simplified via various ‘loop-shifting’ transformations that are naturally expressed in terms of a degree-one polynomial system matrix (PSM) closely related to the Luenberger descriptor form of a system. The technique enables one without loss of generality to restrict attention to the simple case in which D 11 =0, D 22 = 0, D T 12= [0 l], D 21 = [0 l],D l 12 C1=0 and B 1 D T 21 =0. Matrix-fraction descriptions (MFDs) for the algebraic Riccati equation solutions afford another change of variables, which brings the 2-Riccati H∞ controller formulae into a cleaner, more symmetric descriptor form having the important practical advantage that it eliminates the numerical difficulties that can occur in cases where one or both of the Riccati solutions, Pi and Q, blow up and in cases where l— QP is nearly singular. Numerical difficulties previously associated with verifying the existence conditions P ≥ 0, Q ≥ 0, and λmaxlpar;QP) < 1 are largely eliminated by equivalent alternative conditions.
Effect of inactivation method on the cross-protective immunity induced by whole 'killed' influenza A viruses and commercial vaccine preparations (2010)

We have recently shown that intranasal (i.n.) administration of gamma-irradiated A/PR/8 [A/Puerto Rico/8/34 (H1N1)] protects mice against lethal avian influenza A/Vietnam/1203/2004 (H5N1) and other heterosubtypic influenza A infections. Here, we used gamma-irradiated, formalin- and UV-inactivated A/PC [A/Port Chalmers/1/73 (H3N2)] virus preparations and compared their ability to induce both homologous and heterosubtypic protective immunity. Our data show that, in contrast to i.n. vaccination with formalin- or UV-inactivated virus, or the present commercially available trivalent influenza vaccine, a single dose of gamma-ray-inactivated A/PC (gamma-A/PC) conferred significant protection in mice against both homologous and heterosubtypic virus challenges. A multiple immunization regime was required for formalin-inactivated virus preparations to induce protective immunity against a homotypic virus challenge, but did not induce influenza A strain cross-protective immunity. The highly immunogenic gamma-A/PC, but not formalin- or UV-inactivated A/PC, nor the currently available subvirion vaccine, elicited cytotoxic T-cell responses that are most likely responsible for the cross-protective and long-lasting immunity against highly lethal influenza A infections in mice. Finally, freeze-drying of gamma-A/PC did not affect the ability to induce cross-protective immunity.
Ultrasound-mediated reductive condensation synthesis of silicon-silicon-bonded network polymers (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUltrasound-mediated reductive condensation synthesis of silicon-silicon-bonded network polymersPatricia A. Bianconi, Frederic C. Schilling, and Timothy W. WeidmanCite this: Macromolecules 1989, 22, 4, 1697–1704Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April 1989https://pubs.acs.org/doi/10.1021/ma00194a033https://doi.org/10.1021/ma00194a033research-articleACS PublicationsRequest reuse permissionsArticle Views363Altmetric-Citations122LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Hot start of the polymerase chain reaction using DNA helicase]. (1999)

A novel method for the hot start of PCR using DNA helicases is developed. The addition of a DNA helicase prevents the random annealing of primers and synthesis of nonspecific products during the preparation of the reaction mixture and initial heating. The hot start of PCR occurs automatically after inactivation of the DNA helicase upon heating of the reaction mixture.
Low-temperature synthesis of silicon carbide powder using shungite (2016)

The paper presents the results of investigation the novel and simple method of synthesis of silicon carbide. As raw material for synthesis was used shungite, natural mineral rich in carbon and silica. The synthesis of SiC is possible in relatively low temperature in range 1500–1600 °C. It is worth emphasising that compared to the most popular method of SiC synthesis (Acheson method where the temperature of synthesis is about 2500 °C) the proposed method is much more effective. The basic properties of products obtained from different form of shungite and in wide range of synthesis temperature were investigated. The process of silicon carbide formation was proposed and discussed. In the case of synthesis SiC from powder of raw materials the product is also in powder form and not requires any additional process (crushing, milling, etc.). Obtained products are pure and after grain classification may be used as abrasive and polishing powders. Este trabajo presenta un método novedoso de obtención de carburo de silicio a partir de shunguita, mineral natural rico en carbono, y sílice. La síntesis se realiza a temperatura relativamente baja (1.500-1.600 °C) respecto a las temperaturas (∼2500 °C) requeridas en el método Acheson. Se describen la propiedades básicas de los productos obtenidos a partir de diferentes formas de shunguita y utilizando una amplia gama de temperaturas de síntesis. Se propone un proceso de formación del carburo de silicio. Cuando se obtiene el carburo de silicio a partir de materias primas en forma de polvo, el producto tiene también esta forma y no requiere ningún proceso adicional (trituración, molienda, etc.). Una vez clasificados los tamaños, el producto puede utilizarse directamente como abrasivo.
An Analysis on Acoustic Characteristic of the Intersection Noise for Perfomance Improvement in the Accident Sound Detection System (2008)

In this paper, it was performed the analysis on various intersection acoustic patterns for detection rate improvement of accident sound detection system: an acoustic pattern analysis on general traffic noise, an acoustic pattern analysis on engine noise, an acoustic pattern analysis on interfering elements in accident sound detection system.Consequently, traffic accident detection rate will be increased more about 2~3 percent than present 90 percent more or less if the result of this research will be applied to the today's image detection system. There are remarkable differences between an acoustic pattern of traffic noise and one of accident sound, and we must consider a changeable factor when we compose an accident traffic detection system by acoustics because there is error range of 20[dB] according to the volume of traffic in intersection. Also, it is prospected that the acoustic patterns of vehicles type-related engine noise have an insignificant effect on the accident sound detection system because the numerical values of sound pressure are considerably low. Generally, the acoustic patterns of vehicles' horn sound and special purposed- vehicles' sirens have similar sound pressure to the one of accident acoustic patterns but their frequency wave forms are distinctive periodic type, which is quite different from one of accident sound. Consequently, traffic accident detection rate will be increased more about 2~3 percent than present 90 percent more or less if the result of this research will be applied to the today's image detection system.
Sodium sulfonate-functionalized poly(ether ether ketone)s (1998)

A new monomer, sodium 5,5′-carbonylbis(2-fluorobenzenesulfonate) (1), was synthesized by sulfonation of 4,4′-difluorobenzophenone (2) with fuming sulfuric acid. Poly(ether ether ketone)s containing sodium sulfonate groups were synthesized directly via aromatic nucleophilic substitution from the sodium sulfonate-functionalized monomer 1 and Bisphenol A (3) in the presence of potassium carbonate in dimethyl sulfoxide. The polycondensation proceeds without any side reactions. The differential scanning calorimetry measurement indicated that the polymers are amorphous and the glass transition temperatures increase with the content of sodium sulfonate groups in the polymer chain. The degree of substitution with sodium sulfonate groups has strong influence on their thermal stability and solubility.
Q-Value Control of Piezoelectric Vibrator Using Operational Amplifier Circuit (1997)

In application of a piezoelectric vibrator to some electronic devices such as gyro-sensors and piezoelectric ceramic transducers, it is very useful if the value of the resonance quality factor ( Q -value) can be controlled electrically. For achievement of such an ideal, application of a negative impedance converter circuit (NIC circuit) to a piezoelectric vibrator is considered in this work. We applied several negative circuit elements to a piezoelectric vibrator in order to control the Q -value and achieve high performance of it. That is, this work deals with Q -value control of a piezoelectric vibrator by series connection of the NIC circuit, consisting of an operational amplifier, to the vibrator.
Commerson's Leaf-Nosed Bat ( <i>Hipposideros commersoni</i> ) is the Likely Reservoir of Shimoni Bat Virus (2011)

In this study we attempted to identify whether Commerson's leaf-nosed bat (Hipposideros commersoni) is the reservoir of Shimoni bat virus (SHIBV), which was isolated from a bat of this species in 2009. An alternative explanation is that the isolation of SHIBV from H. commersoni was a result of spill-over infection from other species, particularly from the Egyptian fruit bats (Rousettus aegyptiacus), which frequently sympatrically roost with H. commersoni and are known as the reservoir of the phylogenetically related Lagos bat virus (LBV). To evaluate these hypotheses, 769 bats of at least 17 species were sampled from 18 locations across Kenya during 2009?2010. Serum samples were subjected to virus neutralization tests against SHIBV and LBV. A limited amount of cross-neutralization between LBV and SHIBV was detected. However, H. commersoni bats demonstrated greater seroprevalence to SHIBV than to LBV, and greater virus-neutralizing titers to SHIBV than to LBV, with a mean difference of 1.16 log(10) (95% confidence intervals [CI]: 0.94-1.40; p<0.001). The opposite pattern was observed for sera of R. aegyptiacus bats, with a mean titer difference of 1.06 log(10) (95% CI: 0.83-1.30; p<0.001). Moreover, the seroprevalence in H. commersoni to SHIBV in the cave where these bats sympatrically roosted with R. aegyptiacus (and where SHIBV was isolated in 2009) was similar to their seroprevalence to SHIBV in a distant cave where no R. aegyptiacus were present (18.9% and 25.0%, respectively). These findings suggest that H. commersoni is the host species of SHIBV. Additional surveillance is needed to better understand the ecology of this virus and the potential risks of infection to humans and other mammalian species.
Super wide viewer using catadioptrical optics (2003)

Many applications have used a Head-Mounted Display (HMD), such as in virtual and mixed realities, and tele-presence. The advantage of HMD systems is the ease of feeling a 3D world in the display of animation or movies. However, the field of view (FOV) of commercial HMD systems is too narrow for feeling immersion. The horizontal FOV of many commercial HMDs is around 60 degrees, significantly narrower than that of humans. In this paper, we propose a super wide field of view head-mounted display consisting of an ellipsoidal and a hyperboloidal curved mirror. The horizontal FOV of the proposed HMD is 180 degrees and includes the peripheral view of humans. It increases reality and immersion of users. As well, the central region (60 degrees) of the FOV can measure 3D distances using stereoscopics.
On the<i>in vivo</i>photochemical rate parameters for PDT reactive oxygen species modeling (2017)

Photosensitizer photochemical parameters are crucial data in accurate dosimetry for photodynamic therapy (PDT) based on photochemical modeling. Progress has been made in the last few decades in determining the photochemical properties of commonly used photosensitizers (PS), but mostly in solution or in vitro. Recent developments allow for the estimation of some of these photochemical parameters in vivo. This review will cover the currently available in vivo photochemical properties of photosensitizers as well as the techniques for measuring those parameters. Furthermore, photochemical parameters that are independent of environmental factors or are universal for different photosensitizers will be examined. Most photosensitizers discussed in this review are of the type II (singlet oxygen) photooxidation category, although type I photosensitizers that involve other reactive oxygen species (ROS) will be discussed as well. The compilation of these parameters will be essential for ROS modeling of PDT.
Mise en évidence et dénombrement des <i>Listeria </i>à partir de produits laitiers (1991)

La systmatisation des recherches de Listeria dans les produits pathologiques, alimentaires et notamment laitiers, amne optimiser les techniques de mise en vidence et de dnombrement de ces germes. Nous avons donc valu paralllement les performances respectives de la mthode officielle franaise "FDA modifie", partir des travaux de Lovelt publis en 1988 et celles de la mthode dcrite par Van Netten et al (1989) utilisant le milieu Palcam. Les essais montrent une excellente concordance entre les mthodes mais une sensibilit et surtout une rapidit de rsultats suprieure avec le milieu Palcam.
Performance analysis of two echo control designs in ATM networks (1994)

An ATM call interworking with the public switched telephone network may experience echo problems due to impedance mismatch. The authors propose two echo control designs to assure the quality of voice services by reducing round-trip echo delay. Performance of these two echo control designs is then analyzed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Bayesian ACRONYM Tuning (2017)

Extrapolating physical error rates to logical error rates requires many assumptions and thus can radically under- or overestimate the performance of an error correction implementation. We introduce logical randomized benchmarking, a characterization procedure that directly assesses the performance of a quantum error correction implementation at the logical level, and is motivated by a reduction to the well-studied case of physical randomized benchmarking. We show that our method reliably reports logical performance and can estimate the average probability of correctable and uncorrectable errors for a given code and physical channel.
Response of Adult Mosquitoes to Light-emitting Diodes Placed in Resting Boxes and in the Field (2009)

The response of adult mosquitoes to 4 light-emitting diode (LED) wavelengths was evaluated using diode-equipped sticky cards (DESCs) and diode-equipped resting boxes at 2 sites in north central Florida. Wavelengths evaluated were blue (470 nm), green (502 nm), red (660 nm), and infrared (IR) (860 nm). When trapping with DESCs, 15 mosquito species from 7 genera (Aedes, Anopheles, Coquillettidia, Culex, Mansonia, Psorophora, and Uranotaenia) were captured. Overall, approximately 43.8% of all mosquitoes were trapped on DESCs fitted with green LEDs. Significantly more females of Aedes infirmatus, Aedes vexans, and Culex nigripalpus were captured on DESCs fitted with blue LEDs compared with red or IR LEDs. DESCs with blue LEDs captured significantly more Culex erraticus females than those with IR LEDs. Using resting boxes, 12 species from 5 genera (Anopheles, Coquillettidia, Culex, Mansonia, and Uranotaenia) were collected. Resting boxes without LEDs captured 1,585 mosquitoes (22.2% of total). The fewest number of mosquitoes (16.7%) were collected from boxes affixed with the blue LEDs. Significantly more Anopheles quadrimaculatus females were aspirated from resting boxes fitted with red and IR LEDs than from those with blue or green LEDs, or from the unlit control. Blood-fed mosquitoes were recovered in highest numbers from unlit resting boxes, followed by resting boxes fitted with green, IR, and blue LEDs. Culex erraticus accounted for the majority of blood-fed mosquitoes followed by Coquillettidia perturbans. No blood-fed mosquitoes were recovered from resting boxes fitted with red LEDs.