gebhart/patrepeval huggingface dataset:
Efficient logic controller design (2010)

Logic controller is a digital device used for automation of electromechanical processes, such as control of machinery on factory assembly line or lighting fixtures. This paper presents the method for designing a logic controller. We implement it using reprogrammable structure equipped with Embedded Memory Blocks, e.g. CPLD or FPGA. We find that specification of the controller with appropriate statechart diagram and further synthesis as equivalent Finite State Machine yields encouraging results: the number of programmable resources has been reduced approximately by 85%. Result of the research is illustrated with synthesis of practical controllers, where hardware resource consumption is presented. It shows the usefulness of the approach.
Lymphokine Production in Patients with Alzheimer's Disease (1989)

The capacity of peripheral blood mononuclear cells (PBMC) isolated from patients with Alzheimer's disease to produce interleukin-1 and -2 (IL-1, IL-2) was compared to that of cells from age-matched controls and young healthy subjects. There was no difference in the production of both interleukins between patients and their age-matched controls. On the other hand, the production of IL-1 by the PBMC of healthy young volunteers was significantly higher than that of the cells from patients and subjects of the other two groups. Although the results indicated a higher production of IL-2 by PBMC from younger individuals, the difference in comparison with the other two groups was not statistically significant.
Reduction of Noise and Vibration in Vehicles by an Appropriate Engine Mount System and Active Absorbers (1996)

<div class="htmlview paragraph">The ride and noise behavior of a vehicle is significantly affected by vibration transferred from the engine to the chassis through the engine mounts. In this paper conception and design strategies for engine mount systems based upon calculation and experimental methods are discussed. Analyses for static and dynamic engine loads and for idle shake vibrations are presented. The finite element analysis is applied to optimize a mount's rubber spring geometry. Furthermore, the role of the transfer path analysis in the optimization of an engine mount system is illustrated. Passive and semi-active engine mounts that significantly improve the isolation of the idle shake vibration will be discussed. Finally, fully active vibration absorbers which can be applied to solve noise problems, even at a late stage of a new car development program will be presented.</div>
Programming Windows : the Microsoft guide to programming for the MS-DOS Presentation Manager, Windows 2.0 and Windows/386 (1988)

This is an authoritative, example-packed, and thorough reference for Windows API programmers.
The Anatomy and Chemistry Of “Rubbery” Wood in Apple Var. Lord Lambourne (1963)

The anatomy of a one-year-old vertical normal stem of apple var. Lord Lamboume was compared with that of a comparable stem infected with rubbery wood virus and with that of a normal stem caused to undergo an anatomical georeaction by bending it at right angles to the vertical. The stem anatomy of 5-year-old orchard trees showing rubbery wood symptoms was compared with that of comparable normal trees. Staining reactions and investigations using light, polarizing and ultra-violet microscopes, and X-ray diffraction techniques established the anatomical identity of rubbery and georeaction wood.Rubbery wood resembled georeaction wood in having a lignin content less than that of normal wood. It differed from georeaction wood in that oxidation of its lignin produced a molar ratio of syringaldehyde to vanillin which was less than that from normal wood lignin. Rubbery wood gave a yield of milled wood lignin greater than that of normal wood. This suggests that the lignin of rubbery wood is less firmly bound to the polysaccharide framework. This could account for the greater flexibility of rubbery wood.
A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease (2007)

We tested the hypothesis that oral beclomethasone dipropionate (BDP) would control gastrointestinal graft-versus-host disease (GVHD) in patients with anorexia, vomiting, and diarrhea. Patients were randomized to prednisone for 10 days and either oral BDP 8 mg/d (n = 62) or placebo (n = 67) tablets for 50 days. At study day 10, prednisone was rapidly tapered while continuing study drug. On an intent-to-treat basis, the risk of GVHD-treatment failure was reduced for the BDP group at study day 50 (hazard ratio [HR] 0.63, 95% confidence interval [CI] 0.35-1.13) and at 30 days follow-up (HR 0.55, 95% CI 0.32-0.93). Among patients eligible for prednisone taper at study day 10, the risk of GVHD-treatment failure was significantly reduced at both study days 50 and 80 (HR 0.39 and 0.38, respectively). By day 200 after transplantation, 5 patients randomized to BDP had died compared with 16 deaths on placebo, a 67% reduction in the hazard of mortality (HR 0.33, P = .03). In 47 recipients of unrelated and HLA-mismatched stem cells, mortality at transplantation day 200 was reduced by 91% in the BDP group compared with placebo (HR 0.09, P = .02). The survival benefit was durable to 1 year after randomization. Oral BDP prevents relapses of gastrointestinal GVHD following tapering of prednisone; survival is statistically significantly better among patients receiving BDP.
Auto-Setting of Optimal Exposure for Structured Light 3D Cameras (2018)

The quality of 3D point cloud captured by a structured light 3D camera, such as the density and accuracy of the points, depends upon the optimal settings of 3D camera exposure time. The fixed exposure time often set manually, may not be effective under the variation of ambient conditions, e.g., surface reflectance and illumination that incur saturation and/or under-exposure. This is especially the case where 3D cameras are to apply to industrial inspection. In this paper, a novel method for automatically determining the optimal exposure time of a 3D camera based on estimating the pixel intensity-shutter time slope is proposed. The experiments verify that a dense yet accurate 3D point cloud can be captured under varying ambient conditions: up to 40% improvement over the manual setting for the density of captured point cloud.
[Why long-term results?]. (1995)

Lifelong histories are characteristic of orthopaedics. Long-term planning and guidance are essential features of orthopaedic thinking. The indications for operation are based on prognosis, which in turn we only know from long- term observations. Crucial to decision is the weighing of benefit against risk, with or without an operation. This mean: What are the dangers? What may be the benefit, not only for the moment, but in the long run? And what will happen, if we don't operate? Is there a chance of recovery or a risk of later deterioration? Thus, the study and a thorough knowledge of the natural course of a disorder and of the late results of operations are the basis of every orthopaedic treatment, particularly when operative. Further considerations include the ways and means of performing clinical research in orthopaedic surgery, its possibilities and obstacles, the necessity and value of retrospective studies, the issue of prophylactic operations and their inherent dangers, the political and social implications and, finally, the medical doctor's response to all this.
First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases (2010)

FOXN1 deficiency is a primary immunodeficiency characterized by athymia, alopecia totalis, and nail dystrophy. Two infants with FOXN1 deficiency were transplanted with cultured postnatal thymus tissue. Subject 1 presented with disseminated Bacillus Calmette-Guérin infection and oligoclonal T cells with no naive markers. Subject 2 had respiratory failure, human herpes virus 6 infection, cytopenias, and no circulating T cells. The subjects were given thymus transplants at 14 and 9 months of life, respectively. Subject 1 received immunosuppression before and for 10 months after transplantation. With follow up of 4.9 and 2.9 years, subjects 1 and 2 are well without infectious complications. The pretransplantation mycobacterial disease in subject 1 and cytopenias in subject 2 resolved. Subject 2 developed autoimmune thyroid disease 1.6 years after transplantation. Both subjects developed functional immunity. Subjects 1 and 2 have 1053/mm(3) and 1232/mm(3) CD3(+) cells, 647/mm(3) and 868/mm(3) CD4(+) T cells, 213/mm(3) and 425/mm(3) naive CD4(+) T cells, and 10 200 and 5700 T-cell receptor rearrangement excision circles per 100 000 CD3(+) cells, respectively. They have normal CD4 T-cell receptor β variable repertoires. Both subjects developed antigen-specific proliferative responses and have discontinued immunoglobulin replacement. In summary, thymus transplantation led to T-cell reconstitution and function in these FOXN1 deficient infants.
A mesh generator for automatically subdividing irregular polygons into quadrilaterals (1983)

A method for meshing an irregular polygon with an arbitrary number of sides into quadrilaterals is described. The polygon is defined with reference to the coordinates of a set of primary nodes. The polygon sides are the lines joining these nodes and can be straight lines or arcs of circles. Each side may be further subdivided into an arbitrary number of equal length segments. The interior of the polygon is automatically subdivided into quadrilaterals with specification of the primary nodes, side subdivision and side curvature being the only requirements.
The impact of testicular and accessory sex gland function on sperm chromatin integrity as assessed by the sperm chromatin structure assay (SCSA) (2002)

Sex steroid production, spermatogenic function, abstinence time and seminal vesicle function appear to impact on sperm chromatin integrity and thereby on sperm fertilizing capacity. These findings may improve present understanding of the pathophysiology of male infertility.
Energy Transfer from High-Frequency to Low-Frequency Modes in Structures (1995)

A perspective of the mechanisms by which energy is transferred from high- to low-frequency modes is presented. The focus is on some recent experiments that reveal how a low-amplitude high-frequency excitation can produce a large-amplitude low-frequency response. Such a phenomenon is potentially harmful, if not catastrophic. Specifically, these experiments clarify the role of internal resonances, combination external and parametric resonances, and the interactions among modes of widely spaced frequencies.
ANALYSIS OF THE PHYSICALAND CHEMICAL CHARACTERISTICS OF VEGETABLE OILS AS FUEL (2007)

Possible relationships between physical and chemical properties of vegetable oils as biofuels have been studied. 19 samples of vegetable oils of different types and origin were considered. First the relationship between the viscosity of each oil and the temperature was studied. Subsequently, single and multiple regression analyses were carried out between viscosity, iodine number, saponification number and calorific value. It was observed that temperature has a key role in controlling the level of viscosity of the oils, and the relationship between viscosity and temperature is specific to each type of product. Moreover, the chemical structure of the tryglicerides conditions to a great extent the physical, mechanical and energy characteristics of the oil. In particular the length of the carbon chains and the unsaturation level are related to the value of viscosity in a single and multiple relationship. The calorific value increases with the increase in the length of the carbon chain. This study could be useful to develop simplified methods for controlling the quality of vegetable oils as biofuels and for improving the technology of their energy transformation.
Stability of Financial Ratios: A Study of Listed Companies in Singapore (1997)

This study seeks to evaluate the stability of financial ratios across industry and over time. The sample comprises companies listed on the Stock Exchange of Singapore from 1980 to 1991 over six industry groupings. A set of 29 most commonly used ratios was selected for the study. Descriptive statistics, factor analysis and analysis of variance were performed. From the factor analysis results, eight representative ratios were identified. Analysis of variance and multiple comparisons were subsequently performed for each representative ratio to test if it is significantly different across industry and over time. The results indicate that financial ratio averages of the various industries are significantly different. This implies that the appropriate benchmark for evaluating company performance and position should be industry-specific instead of economy based. Also, five of the representative ratios are significantly different over time and not all the industrial averages move consistently over time (i.e., interaction effects of industry and time exist). Thus, industry averages are not necessarily appropriate benchmarks for setting and evaluating performance through time.
Metal Transporter <i>Zip14</i> (<i>Slc39a14</i>) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity (2017)

Mutations in human <i>ZIP14</i> have been linked to symptoms of the early onset of Parkinsonism and Dystonia. This phenotype is likely related to excess manganese accumulation in the CNS. The metal transporter ZIP14 (SLC39A14) is viewed primarily as a zinc transporter that is inducible via proinflammatory stimuli. <i>In vitro</i> evidence shows that ZIP14 can also transport manganese. To examine a role for ZIP14 in manganese homeostasis, we used <i>Zip14</i> knock-out (KO) male and female mice to conduct comparative metabolic, imaging, and functional studies. Manganese accumulation was fourfold to fivefold higher in brains of <i>Zip14</i> KO mice compared with young adult wild-type mice. There was less accumulation of subcutaneously administered <sup>54</sup>Mn in the liver, gallbladder, and gastrointestinal tract of the KO mice, suggesting that manganese elimination is impaired with <i>Zip14</i> ablation. Impaired elimination creates the opportunity for atypical manganese accumulation in tissues, including the brain. The intensity of MR images from brains of the <i>Zip14</i> KO mice is indicative of major manganese accumulation. In agreement with excessive manganese accumulation was the impaired motor function observed in the <i>Zip14</i> KO mice. These results also demonstrate that ZIP14 is not essential for manganese uptake by the brain. Nevertheless, the upregulation of signatures of brain injury observed in the <i>Zip14</i> KO mice demonstrates that normal ZIP14 function is an essential factor required to prevent manganese-linked neurodegeneration.<b>SIGNIFICANCE STATEMENT</b> Manganese is an essential micronutrient. When acquired in excess, manganese accumulates in tissues of the CNS and is associated with neurodegenerative disease, particularly Parkinson-like syndrome and dystonia. Some members of the ZIP metal transporter family transport manganese. Using mutant mice deficient in the ZIP14 metal transporter, we have discovered that ZIP14 is essential for manganese elimination via the gastrointestinal tract, and a lack of ZIP14 results in manganese accumulation in critical tissues such as the brain, as measured by MRI, and produces signatures of brain injury and impaired motor function. Humans with altered ZIP14 function would lack this gatekeeper function of ZIP14 and therefore would be prone to manganese-related neurological diseases.
Poets in dialogue, dialogues in poets (2003)

\n\t\t\t\t\tIs there something noticeably peculiar about dialogues with poets when transformed into writing, be it in electronic or printed form? The pauses and hesitations, the thrust and parry, the slurrings and overlappings of ordinary speech by and large disappear. In their place is an artifice, a deliberate creation of a script, with questions and responses clearly marked for our attention. Might we be approaching a tidied duologue which, some might also cynically remark, largely reproduces a dual monologue? Moreover, when poets are in dialogue, with whom or what does the poet converse?\n\t\t\t\t
Polymeric Nanocomposite Material with a Periodic Structure (2000)

A new approach to producing polymer nanocomposite materials with optically sensitive matrixes is developed. Core−shell latex particles with rigid cores and relatively soft shells are synthesized, packed into a three-dimensional array, and annealed at the temperature at which the shell-forming polymer (SFP) flows and forms a continuous phase, whereas the latex cores remain intact. During latex synthesis, low-molecular-weight species, such as a fluorescent dye, are incorporated into the SFP, thus leading do the polymer-based nanocomposite material with a fluorescent matrix. High modulation in composition and optical properties of the material is achieved by covalently attaching the dye to the SFP, which is accompanied by polymer cross-linking. Mixing of the dye in the SFP, especially when it is not followed by polymer cross-linking, results in a substantial reduction in optical contrast between the particles and the matrix.
Preventing Postoperative Falls in the Older Adult (2007)

aDepartment of Internal Medicine Geriatrics Division, University of Texas Medical Branch at Galveston, Galveston, TX bSealy Center on Aging, University of Texas Medical Branch at Galveston, Galveston, TX Competing Interests Declared: None. Presented at the Symposium "Surgery in the Elderly Patient–Galveston III," Galveston, TX, April 2006. This symposium was generously supported by Genitzinger Endowment Fund; the Sealy Center for Aging; the Department of Surgery, UTMB; and the American Geriatric Society. *Correspondence address: Luis F Amador, MD, Department of Internal Medicine, 3.236 Jennie Sealy Hospital, 301 University Blvd, Galveston, TX 77555-0460. Submitted August 9, 2006; revised November 27, 2006; accepted December 4, 2006.
Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51 (2015)

Artesunate, a semi-synthetic derivative of arteminisin originally developed for the treatment of malaria, has recently been shown to possess antitumor properties. One of the cytotoxic effects of artesunate on cancer cells is mediated by induction of oxidative stress and DNA double-strand breaks (DSBs). We report here that in addition to inducing oxidative stress and DSBs, artesunate can also downregulate RAD51 and impair DSB repair in ovarian cancer cells. We observed that the formation of RAD51 foci and homologous recombination repair (HRR) were significantly reduced in artesunate-treated cells. As a consequence, artesunate and cisplatin synergistically induced DSBs and inhibited the clonogenic formation of ovarian cancer cells. Ectopic expression of RAD51 was able to rescue the increased chemosensitivity conferred by artesunate, confirming that the chemosensitizing effect of artesuante is at least partially mediated by the downregulation of RAD51. Our results indicated that artesunatecan compromise the repair of DSBs in ovarian cancer cells, and thus could be employed as a sensitizing agent in chemotherapy.
Dideoxynucleosides are less inhibitory in vitro against human immunodeficiency virus type 2 (HIV-2) than against HIV-1 (1987)

The antiviral activities of various dideoxynucleosides against LAV strains of human immunodeficiency viruses type 1 (HIV-1) and type 2 (HIV-2) were evaluated. Significantly more 3'-azido-3'-deoxythymidine was required to inhibit the replication of HIV-2 than HIV-1 in three human cell lines. HIV-2 also appeared more resistant than HIV-1 to other dideoxynucleosides. These results suggest that dideoxynucleosides may be less effective in vivo for HIV-2 infection and that a broader range of clinical isolates of human retroviruses should be examined for drug susceptibility in vitro.
Speaker-adaptation for hybrid HMM-ANN continuous speech recognition system (1995)

It is well known that recognition performance degrades signi cantly when moving from a speakerdependent to a speaker-independent system. Traditional hidden Markov model (HMM) systems have successfully applied speaker-adaptation approaches to reduce this degradation. In this paper we present and evaluate some techniques for speaker-adaptation of a hybrid HMM-arti cial neural network (ANN) continuous speech recognition system. These techniques are applied to a well trained, speaker-independent, hybrid HMM-ANN system and the recognizer parameters are adapted to a new speaker through o -line procedures. The techniques are evaluated on the DARPA RM corpus using varying amounts of adaptation material and different ANN architectures. The results show that speaker-adaptation within the hybrid framework can substantially improve system performance.
Perspectives on the high level waste disposal problem (1998)

The problem of high level nuclear waste disposal can be brought into perspective by comparing the waste produced by the nuclear industry with that produced by other electricity generating industries. Negative health effects of the waste produced by these industries can be measured and compared by calculating the risks of fatalities produced by standard waste disposal techniques. This comparison, both on a long term (millions of years) and on a relatively short term (500 years) basis, shows that the health risks are far greater for the coal burning industry and that those for the nuclear industry are minimal and controllable. Further, the author asserts that the nuclear industry is actually helping to reduce radon emissions, and thereby cancer fatalities, through the use and prudent disposal of source uranium.
Near-infrared fluorescence activation probes based on disassembly-induced emission cyanine dye (2015)

Currently most of the fluorogenic probes are designed for the detection of enzymes which work by converting the non-fluorescence substrate into the fluorescence product <i>via</i> an enzymatic reaction. On the other hand, the design of fluorogenic probes for non-enzymatic proteins remains a great challenge. Herein, we report a general strategy to create near-IR fluorogenic probes, where a small molecule ligand is conjugated to a novel γ-phenyl-substituted Cy5 fluorophore, for the selective detection of proteins through a non-enzymatic process. Detail mechanistic studies reveal that the probes self-assemble to form fluorescence-quenched J-type aggregate. In the presence of target analyte, bright fluorescence in the near-IR region is emitted through the recognition-induced disassembly of the probe aggregate. This Cy5 fluorophore is a unique self-assembly/disassembly dye as it gives remarkable fluorescence enhancement. Based on the same design, three different fluorogenic probes were constructed and one of them was applied for the no-wash imaging of tumor cells for the detection of hypoxia-induced cancer-specific biomarker, transmembrane-type carbonic anhydrase IX.