gebhart/patrepeval huggingface dataset:
Integrated Detection, Tracking and Recognition for IR Video-based Vehicle Classification (2007)

We present an approach for vehicle classification in IR video sequences by integrating detection, tracking and recognition. The method has two steps. First, the moving target is automatically detected using a detection algorithm. Next, we perform simultaneous tracking and recognition using an appearance-model based particle filter. We present a probabilistic algorithm for tracking and recognition that incorporates robust template matching and incremental subspace update. There are two template matching methods used in the tracker: one is robust to small perturbation and the other to background clutter. Each method yields a probability of matching. The templates are represented using mixed probabilities and updated when the appearance models cannot adequately represent the variations in object appearance. We also model the tracking history using a nonlinear subspace described by probabilistic kernel principal components analysis, which provides a third probability. The most-recent tracking result is incrementally integrated into the nonlinear subspace by augmenting the kernel Gram matrix with one row and one column. The product of the three probabilities is defined as the observation likelihood used in a particle filter to derive the tracking and recognition result. The tracking result is evaluated at each frame. Low confidence in tracking performance initiates a new cycle of detection, tracking and classification. We demonstrate the robustness of the proposed method using outdoor IR video sequences.
Implementation of dual‐energy technique for virtual monochromatic and linearly mixed CBCTs (2012)

Dual-energy CBCT imaging techniques were implemented to synthesize VM CBCT and LM CBCTs. VM CBCT was effective at achieving metal artifact reduction. Depending on the dose-partitioning scheme, LM CBCT demonstrated the potential to improve CNR for low contrast objects compared to single-energy CBCT acquired with equivalent dose.
The Promoter of the Rat 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene Contains a Tissue-Specific Estrogen-Responsive Region (1999)

The isoprenoid metabolic pathway is mainly regulated at the level of conversion of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) to mevalonate, catalyzed by HMG CoA reductase. As estrogens are known to influence cholesterol metabolism, we have explored the potential regulation of the HMG CoA reductase gene promoter by estrogens. The promoter contains an estrogen-responsive element-like sequence at position −93 (termed Red-ERE), which differs from the ERE consensus by one mismatch in each half of the palindrome. A Red-ERE oligonucleotide specifically bound estrogen receptor in vitro and conferred receptor-dependent estrogen responsiveness to a heterologous promoter in all cell lines tested. However, expression of a reporter driven by the rat HMG CoA reductase promoter was induced by estrogen treatment after transient transfection into the breast cancer cell line MCF-7 cells but not in hepatic cell lines expressing estrogen receptor. Estrogen induction in MCF-7 cells was dependent on the Red-ERE and was strongly inhibited by the antiestrogen ICI 164,384. A functional cAMP-responsive element is located immediately upstream of the Red-ERE, but cAMP and estrogens inhibit each other in terms of transactivation of the promoter. Similarly, induction by estrogens was inhibited by micromolar concentrations of cholesterol, likely acting via changes in occupancy of the sterol-responsive element located 70 bp upstream of the Red-ERE. Thus, within its natural context, Red-ERE is able to mediate hormonal regulation of the HMG CoA reductase gene in tissues that respond to estrogens with enhanced cell proliferation, while it is not operative in liver cells. We postulate that this tissue-specific regulation of HMG CoA reductase by estrogens could partially explain the protective effect of estrogens against heart disease.
Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach (2018)

P300/CBP-associated factor (PCAF) and general control nonderepressible 5 (GCN5) are closely related epigenetic proteins, each containing an acetyltransferase domain and a bromodomain. Consistent with reported roles for these proteins in immune function, we find that PCAF-deficient macrophages exhibit a markedly reduced ability to produce cytokines upon stimulation with lipopolysaccharide (LPS). Investigating the potential to target this pathway pharmacologically, we show that chemical inhibition of the PCAF/GCN5 bromodomains is insufficient to recapitulate the diminished inflammatory response of PCAF-deficient immune cells. However, by generating the first PCAF/GCN5 proteolysis targeting chimera (PROTAC), we identify small molecules able to degrade PCAF/GCN5 and to potently modulate the expression of multiple inflammatory mediators in LPS-stimulated macrophages and dendritic cells. Our data illustrate the power of the PROTAC approach in the context of multidomain proteins, revealing a novel anti-inflammatory therapeutic opportunity for targeting PCAF/GCN5.
The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease (2004)

Donepezil has significant efficacy in the treatment of neuropsychiatric symptoms in patients with mild to moderate AD.
Induction of <i>Neurospora crassa</i> Laccase with Protein Synthesis Inhibitors (1974)

Rapidly growing Neurospora crassa does not produce laccase ( p -diphenol:oxygen oxidoreductase; EC 1.10.3.2). Low concentrations of cycloheximide induce the production of this enzyme, most of which is secreted into the media. In general, limited inhibition of protein synthesis seems to derepress laccase synthesis since actinomycin D and, to a limited extent, puromycin also induce laccase production. Similarities in the conditions of laccase and tyrosinase induction, plus investigations with two tyrosinase regulatory mutants, suggest that the production of these two phenol oxidases is controlled by the same mechanism. As shown by polyacrylamide gel electrophoresis, most of the 10 to 12 proteins normally present in the medium virtually disappear during cycloheximide treatment. In contrast, the amounts of two proteins that are present in only very minor quantities, if at all, in normal culture filtrates increase dramatically. One of these proteins co-migrates with laccase, whereas the other has not been identified.
The effect of stannous fluoride on human plaque acidogenicity in situ (Stephan curve) (1978)

A system employing an Ingold glass electrode was shown to give reliable measurements of pH drops in dental plaque in situ (Stephan curve readings). The system was used to demonstrate that mouthrinses of 0.2 per cent aqueous solutions of stannous fluoride reduced the pH drops markedly for at least seven hours. A reduction of the stannous fluoride concentration increased the pH drops and decreased the duration of the inhibiting effect. A commercial toothpaste containing stannous fluoride and stannous pyrophosphate had an effect similar to the 0.2 per cent mouthrinse. It was shown that tin accumulated in dental plaque after application of solutions containing stannous fluoride. About 40 per cent of the amount of tin present in the plaque immediately after the mouthrinse was still retained seven hours later. It is suggested that the reduction in acid formation may be caused by stannous ions adsorbing to the bacterial cell wall thus disturbing membrane transport mechanisms, or through inhibition of enzyme systems essential in the fermentation of sugars. The observed effect may be a part of the mechanism involved in the caries preventive function of stannous fluoride.
Investigation of Fatty Acid Monolayers on Metals by Contact Potential Measurements<sup>1</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigation of Fatty Acid Monolayers on Metals by Contact Potential Measurements1C. O. Timmons and W. A. ZismanCite this: J. Phys. Chem. 1965, 69, 3, 984–990Publication Date (Print):March 1, 1965Publication History Published online1 May 2002Published inissue 1 March 1965https://pubs.acs.org/doi/10.1021/j100887a050https://doi.org/10.1021/j100887a050research-articleACS PublicationsRequest reuse permissionsArticle Views226Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Hypergraph spectral hashing for similarity search of social image (2011)

The development of social media brings great challenges to image retrieval on both efficiency and accuracy. In addition to achieving fast similarity search over large scale data, it is very crucial to represent the complex and high-order relationships among the social contents to improve the semantic understanding of social images.In this paper, unified hypergraph is implemented to model the various relationships among images and other contexts in social media. Moreover, we extend traditional spectral hashing to hypergraph to accelerate similarity search of social images by mapping semantically related vertices into similar binary codes within a short Hamming distance. Furthermore, the proposed HSH approach is extended to out-of-sample data in a supervised manner. We evaluated our approach on the dataset crawled from Flickr and the experiment results indicate that our proposed HSH approach is both efficient and effective.
SOFTLIB — a documentation management system (1986)

Abstract This paper describes a software sysem (SOFTLIB) that has been developed to assist in the management of software documentation generated during systems development projects. It provides facilities to manage large numbers of documents, to file documents when they are complete and to issue them to system developers and maintainers. It also includes an information retrieval facility that allows programming staff to find documents, to examine their contents before issue and to assess the state of the software project documentation. SOFTLIB is explicitly intended to help manage the documentation generated during software development — it is not designed for use by end‐users of that software or for managing end‐user documentation. The novel characteristic of this system is the approach that is taken to the consistency and completeness of documentation. The documentation associated with a software system is organized in such a way that it may be detected if document sets are complete (that is, if all documentation which should be provided for a software component is available) and if document sets are likely to be inconsistent. This means that if a document has been changed without a comparable change being made to other associated documents, this is detectable by the librarian system. In addition, a subsidiary aim of our work was to investigate the utility of menu systems to complex software tools by building a user interface to SOFTLIB. We conclude that menu systems are far from ideal in such situations because of the range of possible options which must be handled by the system.
Purification and Properties of Orotidine-5′-Phosphate Pyrophosphorylase and Orotidine-5′-Phosphate Decarboxylase from Bakers' Yeast (1971)

Journal Article Purification and Properties of Orotidine-5′-Phosphate Pyrophosphorylase and Orotidine-5′-Phosphate Decarboxylase from Bakers' Yeast Get access Kohei UMEZU, Kohei UMEZU The Faculty of Pharmaceutical Sciences, Kyoto UniversityKyoto Search for other works by this author on: Oxford Academic PubMed Google Scholar Tadahiro AMAYA, Tadahiro AMAYA The Faculty of Pharmaceutical Sciences, Kyoto UniversityKyoto Search for other works by this author on: Oxford Academic PubMed Google Scholar Akio YOSHIMOTO, Akio YOSHIMOTO The Faculty of Pharmaceutical Sciences, Kyoto UniversityKyoto Search for other works by this author on: Oxford Academic PubMed Google Scholar Kenkichi TOMITA Kenkichi TOMITA The Faculty of Pharmaceutical Sciences, Kyoto UniversityKyoto Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 70, Issue 2, August 1971, Pages 249–262, https://doi.org/10.1093/oxfordjournals.jbchem.a129637 Published: 01 August 1971 Article history Received: 07 January 1971 Published: 01 August 1971
Standardization of interphase Ag‐NOR measurement by means of an automated image analysis system using lymphocytes as an internal control (1991)

Using an automated image analysis system, we have developed a procedure for standardizing the measurement of silver-stained proteins of the nucleolar organizer regions (NORs) in cancer cells, irrespective of the fixative employed and the time of the staining reaction. We observed that the area of Ag-NOR proteins from the same tumour was smaller in samples fixed with formalin-containing solutions, buffered formalin, and Bouin liquid, compared with those fixed with absolute ethanol and 'methcarn' solution (1.77 +/- 0.26micron 2 and 2.36 +/- 0.35 micron2 versus 3.34 +/- 0.54 micron2 and 3.72 +/- 0.61 micron2). Increased values of the Ag-NOR area were also observed after lengthening the silver staining reaction. However, in both cases no difference was observed in the ratio between Ag-NOR area of cancer cells and that of the lymphocytes infiltrating the stroma. The value of the ratio, which is called the 'Ag-NOR index', was in fact very similar, for the same cancer, after employing different fixatives or staining times. The use of lymphocyte Ag-NOR area as an internal control for the standardization of Ag-NOR evaluation in cancer tissues was made possible by the fact that lymphocyte Ag-NOR area is almost constant in human tumours independent of sex and age.
POSSIBILITY OF HEARING LOSS FROM EXPOSURE TO INTERIOR AIRCRAFT NOISE (1981)

This report reviews criteria for hearing damage developed by the Committee on Hearing, Bioacoustics and Biomechanics (CHABA) of the National Academy of Science. It presents noise levels occurring in narrow and wide body commercial aircraft, business jet aircraft and short takeoff and landing (STOL) aircraft. It presents estimates of time exposure for pilots and crews based on FAA permitted flight times. It also provides estimations of possible hearing damage resulting from different exposures to interior noise of various aircraft types.
Measurement of cellular elastic properties by acoustic microscopy (1984)

The acoustic microscope is used to investigate the elastic properties of living biological cells. A quantitative model is developed relating acoustic microscope image contrast to cellular elastic properties. Cytoplasmic acoustic attenuation is measured by focusing the acoustic microscope on the surface of the underlying substrate. Cytoplasmic acoustic impedance is measured by focusing the acoustic microscope on the top surface of the cell. The model allows the acoustic microscope to give quantitative information about cellular elasticity on a subcellular scale.
Lake ice measurements from soil water content reflectometer sensors (2015)

Abstract Lake ice depth provides important information about local and regional climate change, weather patterns, and recreational safety, as well as impacting in situ ecology and carbon cycling. However, it is challenging to measure ice depth continuously from a remote location, as existing methods are too large, expensive, and/or time‐intensive. Therefore, we present a novel application that resolves size, cost, and automation issues using commercially‐available soil water content reflectometer sensors from multiple manufactures. Analysis of sensors deployed in an environmental chamber using a scale model of a lake demonstrated accurate measure of the change in ice depth over any time period to within 1 cm, through sensor response of liquid‐to‐solid phase change. A robust correlation exists between volumetric water content in time as a function of environmental temperature and ice growth. This relationship allows us to convert volumetric water content into ice depth. An array of these sensors can be used in lake or river settings to create a temporally high‐resolution ice depth record, which fills in a needed gap for ecological or climatological studies as well as increasing public recreational safety.
Studies on the Utilization of Polyoxymethylene. V. Reaction of Toluene Formaldehyde Resin with Urea (1963)

トルエン・ホルムアルデヒド樹脂(以下TFRと略記)と尿素との反応を酸性触媒下で反応し含窒素樹脂を得た。この含窒素樹脂の構造確認および生成機構を知るため,ベンジルアルコールおよびベンジルエーテルと尿素との反応をモデル実験として行ない,リン酸触媒下,TFRと尿素との反応によって生成する含窒素樹脂はTFRのメチロール基が尿素と反応してウレタン型の結合を生じたもので,エーテル,アセタール等はそのまま樹脂中に残存することがわかった。また,ベンジルアルコールと尿素とを酸性下反応して得られるカルバミン酸ベンジルはホルムアルデヒドと反応して2量体となることを見出した。このものは文献未記載の新化合物である。
A Chemical and Toxicological Comparison of Urban Air PM<sub>10</sub> Collected During Winter and Spring in Finland (2000)

We have used a new high-volume, low-cutoff inertial impactor (HVLI) in a pilot study on chemical characterization and toxicity testing of ambient air PM10 in Helsinki, Finland. Ambient air PM10 was collected at 1100 L/min in 2- to 4-day periods. Two different PM10 samples were selected to represent wintertime combustion type and springtime resuspension type particulate matter (PM) pollution. The most abundant water-soluble ions and elements were analyzed by ion chromatography and inductively coupled plasma mass spectrometry, respectively. The proinflammatory activation ¡NO and interleukin 6 (IL-6) production] and viability of cultured murine RAW 264.7 macrophages were tested in 24-h incubations with increasing mass doses (30-2000 µg per 10(6) cells) from the collected PM10 samples. The winter sample had a higher assessed PM2.5 fraction and sulfate content, and lower chloride, sodium, calcium, aluminum, copper, manganese, and especially iron contents than the spring sample. Both PMjo samples induced dose-dependent NO production in murine macrophages, and the springtime PM10 produced also a strong, dose-dependent IL-6 production. In conclusion, the HVLI proved to be a suitable technique for short-term collection of relatively large ambient air PM masses, enabling extensive chemical characterization and toxicity testing from the same samples.
Role of the Neurogranin Concentrated in Spines in the Induction of Long-Term Potentiation (2006)

Synaptic plasticity in CA1 hippocampal neurons depends on Ca2+ elevation and the resulting activation of calmodulin-dependent enzymes. Induction of long-term depression (LTD) depends on calcineurin, whereas long-term potentiation (LTP) depends on Ca2+/calmodulin-dependent protein kinase II (CaMKII). The concentration of calmodulin in neurons is considerably less than the total concentration of the apocalmodulin-binding proteins neurogranin and GAP-43, resulting in a low level of free calmodulin in the resting state. Neurogranin is highly concentrated in dendritic spines. To elucidate the role of neurogranin in synaptic plasticity, we constructed a computational model with emphasis on the interaction of calmodulin with neurogranin, calcineurin, and CaMKII. The model shows how the Ca2+ transients that occur during LTD or LTP induction affect calmodulin and how the resulting activation of calcineurin and CaMKII affects AMPA receptor-mediated transmission. In the model, knockout of neurogranin strongly diminishes the LTP induced by a single 100 Hz, 1 s tetanus and slightly enhances LTD, in accord with experimental data. Our simulations show that exchange of calmodulin between a spine and its parent dendrite is limited. Therefore, inducing LTP with a short tetanus requires calmodulin stored in spines in the form of rapidly dissociating calmodulin-neurogranin complexes.
Environmental Performance of Sealed Chip-On-Board (scob) Memory Circuits (2005)

This report presents the results of environmental testing of sealed chip-on-board (SCOB) memory circuits. Samples consisted of four SRAM chips mounted on fine line PWBs (MCM-L technology). A complete design of experiments (DOE) matrix included two PWB sources, three die attachment adhesives, one moisture passivation coating (plasma enhanced, chemical vapor deposited silicon nitride), and two encapsulants (a silicone gel and an epoxy glob-top material). DOE was also employed to set up the environmental test scheme using tests selected from MIL-STD-883, and HAST. A set of conventional thin film hybrid circuit samples packaged in hermetic ceramic packages was included in the environmental test scheme as a control. Failure analyses of test samples and conclusions on performance of adhesives and protective coatings are presented.
Two-photon-excitation fluorescence imaging of three-dimensional calcium-ion activity (1994)

Two-photon excitation of the ultraviolet-absorbing fluorescent calcium indicator Indo-1 in laser scanning microscopy makes possible a quantitative, three-dimensional recording of intracellular free calcium activity ([Ca(2equation)](i)) distributions and dynamics with low background and minimal photobleaching. We have constructed a simple optical system that facilitates collection of the 400-500-nm Indo-1 fluorescence without the use of a confocal spatial filter. Instead of the fluorescence being descanned as is normally required in confocal microscopy, the fluorescence is deflected by a dichroic mirror into a separate detection pathway. Images of [Ca(2+)](i) distributions with three-dimensional submicrometer resolution and 10% precision are obtained at100-µM Indo-1 concentration and 3-s recording time for 384 × 512 pixels. Data on [Ca(2+)](i) in tumor mast cells and cardiac myocytes illustrate the capabilities of this technique.
Research on Behavioral Decision Method of Simulation Entity Based on Cognitive Model (2013)

This paper studies how to use the cognitive model to model the behavioral decision-making for the tactical level simulation. The decision making process includes initial behavior planning and behavior modification. This method has the advantages of accuracy and real-time, this makes the behaviors of the simulation entity more realistic and improves the credibility of simulation.