gebhart/patrepeval huggingface dataset:
Aplicación práctica y adaptación de la herramienta Coeficiente U en una unidad de innovación educativa de una universidad pública de Santiago de Chile (2016)

Este articulo presenta los resultados de la aplicacion de la herramienta Coeficiente U en una Unidad de Innovacion Educativa, para identificar su nivel de innovacion interna. Este instrumento, originalmente desarrollado por el Grupo de Investigacion en Politica y Gestion Tecnologica de la Escuela de Ingenierias de la Universidad Pontificia Bolivariana de Colombia (UPB), fue modificado para que los encuestados senalaran sus propias experiencias. Los resultados y conclusiones mas relevantes de esta investigacion establecen que la barrera mas importante para la Unidad investigada esta relacionada con la falta de tiempo para desarrollar todas sus actividades innovativas, esto a pesar de contar con personal calificado para ello. Por otra parte, su fortaleza se encuentra en su capital humano de alto profesionalismo para ejecutar los proyectos que desarrollan en periodos de sobrecarga de trabajo, y enfrentar situaciones complejas, tales como las movilizaciones estudiantiles.
The System of Rice Intensification: Time for an empirical turn (2011)

The System of Rice Intensification (SRI) is claimed to be a new, more productive and more sustainable method for cultivating rice. These claims have proved controversial. One dimension of the controversy has centred on the imprecision with which SRI's component practices have been defined. The supporters of SRI suggest that the system has been designed to satisfy the needs of rice itself, implying that it is a set of integrated, mutually reinforcing practices that need to be implemented as a package in order to obtain the best results. However, they also argue that the system should be understood as a suite of flexible principles to be adapted to particular agro-ecological and socio-economic settings – the antithesis of a fixed package. This poses a conceptual and practical challenge for scientific evaluation of SRI methods. However, this apparent difficulty is chiefly an artefact created by conceptualizing agricultural methods as standardized packages. A process of translation is always necessary to convert theoretical models or norms into farming practices. Smallholder farming practices, being intrinsically constrained and contingent, rarely conform precisely to abstract norms. As an alternative, the notion of performance offers a useful way to frame a methodological and analytical approach to understanding what is going on in SRI. Such an approach calls for close technographic observation of farming activities and the interaction between farmers and their fields, plants and tools
Acute myeloid leukemias with chromosomal abnormalities involving the 21q22 region identified by their in vitro responsiveness to interleukin-5. (1991)

Among 52 patients diagnosed as acute myeloid leukemia (AML), nine cases were found in which interleukin-5 (IL-5) induced a proliferative response in the leukemic cells, as measured by the stimulation of DNA synthesis or colony formation in vitro. All cases (n = 7) with the cytogenetic abnormality t(8;21)(q22;q22) belonged to this group of IL-5 responders. Of the additional two cases, one had an apparently normal karyotype, but the other expressed a dicentric chromosome 21, an abnormality also involving the breakpoint region 21q22. The leukemic cells of the IL-5 responsive patients could also be stimulated to proliferate by IL-3, GM-CSF and G-CSF, and in some cases by IL-6 or M-CSF. Immunophenotypic analysis revealed the presence of the immature hematopoietic cell antigen CD34, the myelomonocytic maturation antigens CD13 and CD33, in association with the B-cell related surface marker CD19 on the leukemic cells. Immunoglobulin mu and T-cell receptor beta-genes in the leukemic cells were in germline configuration. Upon incubation in colony culture, clonogenic cells were capable of producing progeny showing eosinophilic or neutrophilic maturation following stimulation with IL-5 or G-CSF, respectively. It is concluded that IL-5 responsive AML represents a subgroup of leukemia with distinct immunotypic and cytogenetic features.
Liquid-Phase Methanation of High Concentration CO Synthesis Gas (1975)

Chem Systems is conducting a development program for the methanation of synthesis gases as part of a joint program of the United States Office of Coal Research and the American Gas Association. The objective is to develop practical methods for producing substitute natural gas from coal. Chem Systems' process involves the reaction of CO and H2 in a liquid-fluidized catalyst system which is a novel way of effecting highly exothermic gas-gas reactions that offers several advantages over present technology. Experimental data were obtained on both bench-scale and process development units. Process variables are examined, and a kinetic model is developed to define the reaction mechanism.
An isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP-induced transcription. (1994)

cAMP response element-binding protein (CREB) and modulator protein (CREM) regulate the transcription of cAMP-responsive genes via phosphorylation by cAMP-dependent protein kinase A. Reverse transcription and polymerase chain amplification of RNA from male germ cells identify an alternatively spliced CREM isoform, CREM delta C-G, lacking four exons including those encoding the protein kinase A-regulated phosphorylation domain and the flanking glutamine-rich transcriptional activation domains. CREM delta C-G retains exons that encode the basic-leucine zipper (bZIP) DNA-binding domain, binds to cAMP response elements (CREs), and competitively inhibits binding of CREB and CREM to CREs. Expression of CREM delta C-G inhibits transcription of a CRE-containing chloramphenicol acetyltransferase reporter plasmid induced by endogenous CREB. Antiserum to CREM detects CREM delta C-G in elongated spermatids from rat testis. These observations indicate that CREM delta C-G is a unique form of a competitive negative regulator of CREB-mediated gene transcription expressed in a maturation-dependent manner in haploid germ cells. The developmental specificity of CREM delta C-G suggests that it may play a role in transcriptional regulation during spermatogenesis.
Low cost transformer isolated boost half-bridge micro-inverter for single-phase grid-connected photovoltaic system (2012)

This paper presents a low cost high efficiency transformer isolated micro-inverter for single-phase grid-connected photovoltaic (PV) system. The proposed micro-inverter is composed of two stages, an isolated dc-dc converter stage and an inverter stage with a dc link. A high frequency transformer isolated high voltage gain boost half-bridge dc-dc converter is used at the first stage to achieve maximum power point tracking (MPPT) and to step up the PV voltage to the high voltage dc-link. A pulse width modulated (PWM) full-bridge inverter with LCL filter is used at the second stage to output the synchronized sinusoid current with unity power factor to the grid. By utilizing the transformer leakage inductance, two primary side switches can achieve zero voltage switching (ZVS). A 210 W prototype of the proposed micro-inverter has been built and tested. The efficiency of the proposed boost half-bridge dc-dc converter has been measured according to the PV curve, which is up to 98.2%. Experimental results are provided to demonstrate the validity and features of the proposed circuit.
Organometallic Anticancer Compounds (2010)

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTOrganometallic Anticancer CompoundsGilles Gasser*†§, Ingo Ott*‡, and Nils Metzler-Nolte*§View Author Information† Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland‡ Institute of Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig, Germany§ Chair of Inorganic Chemistry I, Bioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstrasse 150, 44801 Bochum, Germany*To whom correspondence should be addressed. For G.G.: phone, +41(0)44 635-4611; fax, +41(0)44 635-6803; e-mail, [email protected]; Web page, www.gassergroup.com. For I.O.: phone, +49 (0)531-391 2743; fax, +49 (0)531-391 8456; e-mail, [email protected]; Web page, www.pharmchem.tu-bs.de/forschung/ott/. For N.M.-N.: phone, +49 (0)234-32 28152; fax, +49 (0)234-32 14378; e-mail, [email protected]; Web page, www.chemie.rub.de/ac1.Cite this: J. Med. Chem. 2011, 54, 1, 3–25Publication Date (Web):November 15, 2010Publication History Received8 January 2010Published online15 November 2010Published inissue 13 January 2011https://doi.org/10.1021/jm100020wCopyright © 2010 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views34024Altmetric-Citations1313LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-AlertscloseSUBJECTS:Genetics,Ligands,Metals,Reaction products,Sandwich compounds Get e-Alerts
New antitumor anthracyclines. (1977)

<p>Using a recently developed alternative assay procedure to measure hormone levels from hair samples, we examined the relationships between testosterone, cortisol, 2D:4D ratio, overconfidence and risk taking. A total of 162 (53 male) participants provided a 3 cm sample of hair, a scanned image of their right and left hands from which we determined 2D:4D ratios, and completed measures of overconfidence and behavioral risk taking. While our sample size for males was less than ideal, our results revealed no evidence for a relationship between hair testosterone concentrations, 2D:4D ratios and risk taking. No relationships with overconfidence emerged. Partially consistent with the Dual Hormone Hypothesis, we did find evidence for the interacting effect of testosterone and cortisol on risk taking but only in men. Hair testosterone concentrations were positively related to risk taking when levels of hair cortisol concentrations were low, in men. Our results lend support to the suggestion that endogenous testosterone and 2D:4D ratio are unrelated and might then exert diverging activating vs. organizing effects on behavior. Comparing our results to those reported in the existing literature we speculate that behavioral correlates of testosterone such as direct effects on risk taking may be more sensitive to state-based fluctuations than baseline levels of testosterone.</p>
The contingent rationality of housing preferences: Homeless mentally ill persons' housing choices before and after housing experience (2005)

Prior research indicates that homeless consumers of mental health services have a marked preference for independent living, while clinicians tend to recommend staffed, group housing. In order to understand this divergence and identify its consequences for mental health policy, we test influences on housing preferences suggested by rational choice and social structural perspectives. We use a randomized field trial of independent and group housing to identify the consequences for subsequent housing loss and consumer functioning of consumer- and clinician-determined housing placements. We find that consumer preference at baseline for independent living indicates greater vulnerability to housing loss, but the bases of preferences change after consumers gained experience with stable housing. We interpret the results as indicating the contingent rationality of preferences and the susceptibility of preferences to change with experience.
A 50 K dual-mode sapphire oscillator and whispering spherical mode oscillators (2007)

[Truncated abstract] This thesis is split into two parts. In part one; A 50 K dual mode oscillator, the aim of the project was to build a 50 K precision oscillator with frequency stability on the order of 1014 from 1 to 100 seconds. A dual-mode temperature compensation technique was used that relied on a turning point in the frequency-temperature relationship of the difference frequency between two orthogonal whispering gallery modes in a single sapphire crystal. A cylindrical sapphire loaded copper cavity resonator was designed, modelled and built with a turning point in the difference frequency between an E-mode and H-mode pair at approximately 52.5 K . . . The frequencies and Q-factors of whispering spherical modes in the 3-12 GHz range in the fused silica resonator are measured at 6, 77 and 300 K and the Q-factor is used to determine the loss tangent at these temperatures. The frequency and Q-factor temperature dependence of the TM2,1,2 whispering gallery mode at 5.18 GHZ is used to characterise the loss tangent and relative permittivity of the fused silica from 4-300 K. Below 22 K the frequency-temperature dependence of the resonator was found to be consistent with the combined effects of the thermal properties of the dielectric and the influence of an unknown paramagnetic impurity, with a spin resonance frequency at about 138 ± 31 GHz. Below 8 K the loss tangent exhibited a 9th order power law temperature dependence, which may be explained by Raman scattering of Phonons from the paramagnetic impurity ions. A spherical Bragg reflector resonator made from multiple concentric dielectric layers loaded in a spherical cavity that enables confinement of field in the centre of the resonator is described. A set of simultaneous equations is derived that allow the calculation of the required dimensions and resonance frequency for such a resonator and the solution is confirmed using finite element analysis. A spherical Bragg reflector resonator is constructed using Teflon and free-space as the dielectric materials. A Q-factor of 22,000 at 13.87 GHz was measured and found to compare well with the design values.
Indirect vs direct measurement of magnesium and zinc in erythrocytes. (1987)

We evaluated three methods (two indirect and one direct) for determining the magnesium (Mg) and zinc (Zn) content of erythrocytes, to compare methodologic differences and to establish a method suitable for use in field studies. For the indirect methods, erythrocytes in whole blood were lysed by adding either de-ionized water (I) or nitric acid, 2 mol/L (II). For the direct method (III), erythrocytes were isolated by density centrifugation, washed, then digested in concentrated HNO3. Mg and Zn concentrations were measured by atomic absorption spectrophotometry in plasma and whole blood for the indirect methods, and in the pellet for the direct method. Hematocrit and hemoglobin were measured, and erythrocytes were sized and counted on all samples. Within-run CVs for the three methods ranged from 2.2% with method III for Mg to 5.4% with method I for Zn. CVs for reproducibility of the analytical procedures ranged from 2.6% with method II for Zn to 4.2% with method I for the two cations. Analytical recoveries of added Mg and Zn ranged from 93.8 to 104.7%. When values for the three methods were compared, those by method I were significantly (p less than 0.05) lower than those by methods II and III. Values obtained by method II were 100.1% for Mg and 102.4% for Zn of those by the direct method. Thus, the indirect method with 2 mol/L HNO3 lysing solution provides a reproducible, reliable, accurate, and simple technique for measuring Mg and Zn in erythrocytes.
THERMAL PATTERNS IN 36 INCH FREIGHT CAR WHEELS DURING SERVICE TESTS (1976)

Service tests were conducted on the Atchison, Topeka and Santa Fe Railway Co. track at various speeds with an instrumented brake beam to determine the normal (perpendicular) and retarding (circumferential) brake shoe forces applied to a wheel set. The specially designed brake beam and load measuring transducers were installed in a truck under a 100-ton gondola used as the test car. The wheel set installed in this truck consisted of two different wheel designs mounted on the same axle. These wheels were instrumented with thermocouples embedded in the tread and plate areas to determine the temperature generated under controlled service brake application. Different types of brake shoes instrumented with thermocouples were also used to determine wheel-brake shoe heat flow characteristics. The retarding force applied to the wheel tread surface by the brake shoe was controlled by an air source independent of the train line source.
Insulin unmasks a COOH-terminal Glut4 epitope and increases glucose transport across T-tubules in skeletal muscle. (1996)

An improved immunogold labeling procedure was used to examine the subcellular distribution of glucose transporters in Lowricryl HM20-embedded skeletal muscle from transgenic mice overexpressing either Glut1 or Glut4. In basal muscle, Glut4 was highly enriched in membranes of the transverse tubules and the terminal cisternae of the triadic junctions. Less than 10% of total muscle Glut4 was present in the vicinity of the sarcolemmal membrane. Insulin treatment increased the number of gold particles associated with the transverse tubules and the sarcolemma by three-fold. However, insulin also increased the total Glut4 immunogold reactivity in muscle ultrathin sections by up to 1.8-fold and dramatically increased the amount of Glut4 in muscle sections as observed by laser confocal immunofluorescence microscopy. The average diameter of transverse tubules observed in longitudinal sections increased by 50% after insulin treatment. Glut1 was highly enriched in the sarcolemma, both in the basal state and after insulin treatment. Disruption of transverse tubule morphology by in vitro glycerol shock completely abolished insulin-stimulated glucose transport in isolated rat epitrochlearis muscles. These data indicate that: (a) Glut1 and Glut4 are targeted to distinct plasma membrane domains in skeletal muscle; (b) Glut1 contributes to basal transport at the sarcolemma and the bulk of insulin-stimulated transport is mediated by Glut4 localized in the transverse tubules; (c) insulin increases the apparent surface area of transverse tubules in skeletal muscle; and (d) insulin causes the unmasking of a COOH-terminal antigenic epitope in skeletal muscle in much the same fashion as it does in rat adipocytes.
Multispectral decomposition for the removal of out-of-band effects of visible/infrared imaging radiometer suite visible and near-infrared bands (2012)

The visible/infrared imaging radiometer suite (VIIRS) is now onboard the first satellite platform managed by the Joint Polar Satellite System of the National Oceanic and Atmospheric Administration and NASA. It collects scientific data from an altitude of approximately 830 km in 22 narrow bands located in the 0.4-12.5 μm range. The seven visible and near-infrared (VisNIR) bands in the wavelength interval between 0.4-0.9 μm are known to suffer from the out-of-band (OOB) responses--a small amount of radiances far away from the center of a given band that can pass through the filter and reach detectors in the focal plane. A proper treatment of the OOB effects is necessary in order to obtain calibrated at-sensor radiance data [referred to as the Sensor Data Records (SDRs)] from measurements with these bands and subsequently to derive higher-level data products [referred to as the Environmental Data Records (EDRs)]. We have recently developed a new technique, called multispectral decomposition transform (MDT), which can be used to correct/remove the OOB effects of VIIRS VisNIR bands and to recover the true narrow band radiances from the measured radiances containing OOB effects. An MDT matrix is derived from the laboratory-measured filter transmittance functions. The recovery of the narrow band signals is performed through a matrix multiplication--the production between the MDT matrix and a multispectral vector. Hyperspectral imaging data measured from high altitude aircraft and satellite platforms, the complete VIIRS filter functions, and the truncated VIIRS filter functions to narrower spectral intervals, are used to simulate the VIIRS data with and without OOB effects. Our experimental results using the proposed MDT method have demonstrated that the average errors after decomposition are reduced by more than one order of magnitude.
cis-diamminedichloroplatinum(II) nephrotoxicity: tubular function after rescue with sodium diethyldithiocarbamate in rats. (1983)

Sodium diethyldithiocarbamate (DDTC) administered following cis-diamminedichloroplatinum(II) (DDP) has been reported to attenuate structural renal damage and elevation of blood urea nitrogen in rats. Since DDP damages primarily proximal tubular epithelium in this species, we compared proximal tubular function, glomerular function, and histology in male Sprague-Dawley rats treated with DDP followed by either DDTC or 0.9% NaCl solution (NS) rescue. Male Sprague-Dawley rats received a single i.p. injection of DDP (7.5 mg/kg)-mannitol (75 mg/kg)-NaCl (67.5 mg/kg). Forty-five min later, rats were given i.p. injections of either DDTC (750 mg/kg) dissolved in 0.5 ml of NS (DDP + DDTC group; ten rats) or 0.5 ml NS (DDP + NS group; nine rats); additional rats received either DDTC only (DDTC group; six rats) or no treatment (untreated control group; six rats). All groups were sacrificed 5 days later by ether anesthesia and exsanguination. Compared to the untreated control group, the DDTC group had slightly lower mean blood urea nitrogen at sacrifice [12.5 +/- 0.5 (S.E.) versus 15.4 +/- 0.8 mg/dl; p less than 0.025 by unpaired Student's t test]; there was no difference in serum creatinine. The DDP + DDTC group had no diarrhea and no presacrifice deaths in contrast to diarrhea and three presacrifice deaths in the DDP + NS group. Blood urea nitrogen was also lower in the DDP + DDTC group at sacrifice (187 +/- 30 versus 383 +/- 39 mg/dl; p less than 0.005). However, weight loss and serum creatinine were not different. Structural acute tubular necrosis was marked in both DDP groups but was less severe in the DDP + DDTC group than in the DDP + NS group. Proximal tubular function was indexed by the uptake of the organic base N-[14C]methyl nicotinamide (NMN) and the organic acid p-aminohippurate in renal cortical slices incubated 90 min in Cross and Taggart medium. NMN uptake (expressed as slice to medium ratio) was slightly lower in the DDTC group than in untreated controls (4.1 +/- 0.2 versus 5.0 +/- 0.2; p less than 0.025). Marked depression of p-aminohippurate and NMN uptake occurred in both DDP + DDTC and DDP + NS groups. There was no difference in NMN uptake, but depression of p-aminohippurate uptake was slightly less severe in the DDP + DDTC group (5.3 +/- 0.7 versus 3.1 +/- 0.3; p less than 0.005). We conclude that DDTC rescue attenuates structural DDP injury in this animal model. DDP-mediated proximal tubular dysfunction was only marginally attenuated by DDTC; glomerular filtration rate, as indexed by serum creatinine, was not protected. DDTC attenuation of DDP toxicity may be mediated in part via reducing volume depletion due to DDP-associated diarrhea.