gebhart/patrepeval huggingface dataset:
Molecular cloning and gibberellin-induced expression of multiple cysteine proteinases of rice seeds (oryzains). (1991)

We screened a cDNA library of germinating rice seeds with a cDNA for aleurain (cysteine proteinase from barley) and obtained three distinct types of cDNA clones encoding three species of cysteine proteinases (oryzains alpha, beta, and gamma). The deduced amino acid sequences are distinct in part, but, on the whole, are similar to one another. The three sequences all contain the catalytic triad Cys25-His159-Asn175 (papain numbering). The three oryzains are similar to one another and also to other known cysteine proteinases such as papain and cathepsin H with respect to the sequences around the active site residues and the COOH-terminal Trp-rich region. Amino acid sequence comparison revealed that oryzains alpha and beta are similar not only to each other (70% similarity) but also to actinidin and papain (about 50%), whereas oryzain gamma was rather similar to aleurain (85%) and cathepsin H (60%). Northern blot analysis revealed that the mRNAs for the three oryzains are expressed only in seeds, not in shoots or roots, and show different expression profiles during germination and when the seeds are treated with gibberellic acid. Oryzains alpha and gamma are expressed continuously during germination with a maximum expression 5 days from the start of germination, but are present in neither ripening nor ripened seeds. On the other hand, oryzain beta is expressed not only during germination, but also in ripened seeds before germination. It was noted that the expression of the three oryzain mRNAs is enhanced in different manners by gibberellic acid but is not enhanced by other plant hormones such as auxin. The induction of oryzain beta mRNA is transient, reaching a maximum in 4 h from the addition of giberellic acid and diminishing rapidly thereafter, while the induction of oryzain alpha and gamma mRNAs continues over 5 days. Thus, multiple systems involving cysteine proteinases must be differentially involved in the germination process, probably under hormonal control.
3D object segmentation for shelf bin picking by humanoid with deep learning and occupancy voxel grid map (2016)

Picking objects in a narrow space such as shelf bins is an important task for humanoid to extract target object from environment. In those situations, however, there are many occlusions between the camera and objects, and this makes it difficult to segment the target object three dimensionally because of the lack of three dimensional sensor inputs. We address this problem with accumulating segmentation result with multiple camera angles, and generating voxel model of the target object. Our approach consists of two components: first is object probability prediction for input image with convolutional networks, and second is generating voxel grid map which is designed for object segmentation. We evaluated the method with the picking task experiment for target objects in narrow shelf bins. Our method generates dense 3D object segments even with occlusions, and the real robot successfully picked target objects from the narrow space.
An Immaterial, Dual-sided Display System with 3D Interaction (2006)

We present an interactive wall-sized immaterial display that introduces a number of interesting possibilities for advanced interface design. The immaterial nature of a thin sheet of fog allows users to penetrate and even walk through the screen, while its dual-sided nature allows for new possibilities in multi-user faceto- face collaboration and pseudo-3D visualization.
A better update policy (1994)

Some file systems can delay writing modified partially-filled data block results in a delayed write, while a modification that fills a block results in an immediate, although asynchronous, write. The data to disk, in order to reduce disk traffic and over-ULTRIX ™ operating system can be configured to be head. Prudence dictates that such delays be bounded, even more aggressive, delaying all writes of modified in case the system crashes. We refer to an algorithm data. used to decide when to write delayed data back to Without some bound on the age of a delayeddisk as an update policy. Traditional UNIX ® systems write block, a system crash could cause loss of aruse a periodic update policy, writing back all bitrary data. Users would not tolerate this, so the file delayed-write data once every 30 seconds. Periodic system does push delayed-write data out to disk, after update is easy to implement but performs quite badly a while. We use the term update policy to describe in some cases. This paper describes an approximate the algorithm that decides what to write out, and implementation of an interval periodic update policy, when. in which each individual delayed-write block is written when its age reaches a threshold. Interval peri-odic update adds little code to the kernel and can perform much better than periodic update. In particular, interval periodic update can avoid the huge variances in read response time caused by using peri-odic update with a large buffer cache. UNIX systems have traditionally used a simple periodic update (or ‘‘PU’’) policy: once every 30 seconds, all dirty blocks in the file system’s buffer cache are placed on the output queue for the ap-propriate disk. Recent analytical and simulation results, presented by Carson and Setia [2], showed that the PU policy actually performs worse in many cases than the write-through (WT) policy (in which 1.
Variational surface modeling (1992)

article Variational surface modeling Share on Authors: William Welch School of Computer Science, Carnegie Mellon University, Pittsburgh, PA School of Computer Science, Carnegie Mellon University, Pittsburgh, PAView Profile , Andrew Witkin School of Computer Science, Carnegie Mellon University, Pittsburgh, PA School of Computer Science, Carnegie Mellon University, Pittsburgh, PAView Profile Authors Info & Claims ACM SIGGRAPH Computer GraphicsVolume 26Issue 2July 1992 pp 157–166https://doi.org/10.1145/142920.134033Online:01 July 1992Publication History 259citation1,611DownloadsMetricsTotal Citations259Total Downloads1,611Last 12 Months36Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Origin and propagation of interictal discharges in the acute electrocorticogram. Implications for pathophysiology and surgical treatment of temporal lobe epilepsy (1997)

Although acute electrocorticography (ECoG) is routinely performed during epilepsy surgery there is little evidence that the extent of the discharging regions is a useful guide to tailoring the resection or that the findings are predictive of outcome or pathology. Patterns of discharge propagation have, however, rarely been considered in assessing the ECoG. We hypothesize that regions where discharges show earliest peaks ('leading regions') are located in the epileptogenic zone, whereas sites in which late, secondary, propagated activity occurs have less epileptogenic potential and do not need to be excised. To allow intraoperative topographic ECoG analysis, a computer program has been developed to identify leading regions and the sites showing greatest rates or amplitudes of spikes. Their topography has been compared retrospectively with pathology and seizure control in 42 consecutive patients following temporal lobe surgery. Leading regions were most often found in the hippocampus, the subtemporal cortex and the superior temporal gyrus. The most common propagation patterns were from hippocampus to subtemporal cortex and vice versa. There was no association between seizure outcome and the location of regions with greatest incidence or amplitude of spikes or location of leading regions. There was, however, a strong and significant association between poor outcome and non-removal of leading regions other than those in the posterior subtemporal cortex. All leading regions (other than posterior subtemporal) were resected in 27 patients of whom 25 had a favourable outcome. Leading regions (other than posterior subtemporal) remained in 14 patients of whom only four had a good outcome. One patient had no epileptiform activity in the ECoG and good outcome. Persistent posterior subtemporal leading regions remained in nine subjects; all had favourable outcome (Grades I or II) but only three were seizure free. These results suggest that: (i) interictal epileptiform discharges may originate from a complex interaction between separate regions, resulting in propagation and recruitment of neuronal activity along specific neural pathways; (ii) removal of all discharging areas appears unnecessary to achieve seizure control provided that leading regions (other than posterior subtemporal) are removed; and (iii) identification of such leading regions could be used to tailor resections in order to improve seizure control and reduce neurological, neuropsychological and psychiatric post-surgical morbidity.
Voltage controlled sub-THz detection with gated planar asymmetric nanochannels (2018)

This letter reports on room temperature sub-THz detection using self-switching diodes based on an AlGaN/GaN heterostructure on a Si substrate. By means of free-space measurements at 300 GHz, we demonstrate that the responsivity and noise equivalent power (NEP) of sub-THz detectors based on planar asymmetric nanochannels can be improved and voltage controlled by means of a top gate electrode. A simple quasi-static model based on the DC measurements of the current-voltage curves is able to predict the role of the gate bias in its performance. The best values of voltage responsivity and NEP are achieved when the gate bias approaches the threshold voltage, around 600 V/W and 50 pW/Hz1/2, respectively. A good agreement is found between modeled results and those obtained from RF measurements under probes at low frequency (900 MHz) and in free-space at 300 GHz.
Design of a N20/HTPB Hybrid Rocket Motor Utilizing a Toroidal Aerospike Nozzle (2010)

Current efforts by the student members of the sole student rocket group at Arizona State University, Daedalus Astronautics, have been focused on development of both a hybrid rocket motor and an aerospike nozzle. Hybrid rocket propulsion has combined properties of both solid and liquid rockets giving it advantages over the individual systems. This is a concept which has gained a more substantial footing with the success of Scaled Composites and SpaceShipOne. Daedalus Astronautics has designed and developed a simple hybrid rocket motor for the use in their high-powered sounding rocket program. The designed motor utilizes nitrous oxide and hydroxyl-terminated polybutadiene (HTPB) for oxidizer and fuel respectively. The key components of the hybrid design and analysis include the oxidizer solenoid valve, injector, pre-combustion chamber, fuel grain, post combustion chamber and nozzle. Initial testing of the hybrid rocket motor have been conducted utilizing a standard “bell” nozzle in order to allow for direct comparison to a more advanced nozzle design. A toroidal aerospike nozzle with an isentropic contour was designed and implemented for use with the hybrid due to its advantages over the standard and widely used “bell” shaped nozzle. An aerospike nozzle has the ability to perfectly expand the exhaust gas at all altitudes increasing the performance of the system. This design includes the use of graphite inserts at the nozzle throat to deter erosion and expansion which has been problems in previous designs. By integrating this nozzle with the hybrid rocket motor a high performance launch system can be achieved.
A family of glycolipids from Toxoplasma gondii. Identification of candidate glycolipid precursor(s) for Toxoplasma gondii glycosylphosphatidylinositol membrane anchors. (1992)

Four major glycolipids were extracted from Toxoplasma gondii tachyzoites which were metabolically labeled with tritiated glucosamine, mannose, palmitic and myristic acid, ethanolamine, and inositol. Judging from their sensitivity to a set of enzymatic and chemical tests, these glycolipids share the following properties with the glycolipid moiety of the glycosylphosphatidylinositol anchor (GPI anchor) of the major surface protein, P30, of T. gondii: 1) a nonacetylated glucosamine-inositol phosphate linkage; 2) sensitivity toward phosphatidylinositol-specific phospholipase C and nitrous acid; 3) identity of HF-dephosphorylated GPI glycan backbone between three glycolipids and the HF-dephosphorylated core glycan of the GPI anchor of the major surface protein P30; 4) the presence of a linear core glycan structure blocked by an ethanolamine phosphate residue(s). Taken together with the nature of radiolabeled precursors incorporated into these glycolipids, the data indicate that these GPIs are involved in the biosynthesis of the GPI-membrane anchors of T. gondii.
Methotrexate analogs. 15. A methotrexate analogue designed for active-site-directed irreversible inactivation of dihydrofolate reductase (1982)

N alpha-(4-Amino-4-deoxy-N10-methylpteroyl)-N epsilon-(iodoacetyl)-L-lysine (1) was synthesized as a potential active-site-directed irreversible inhibitor of dihydrofolate reductase (DHFR). In an ultraviolet spectrophotometric assay of dihydrofolate reduction of Lactobacillus casei DHFR, 1 and methotrexate (MTX, 4-amino-4-deoxy-N10-methylpteroyl-L-glutamic acid) had ID50 values of 4.5 and 6.2 nM. The corresponding ID50 values in a competitive radioligand binding assay against [3H]MTX were 31 and 16 nM. Thus, as reversible inhibitors of this enzyme over a short exposure time, 1 and MTX had comparable activity. On the other hand, when L. casei DHFR was incubated for up to 6 h with 0.1 or 1.0 microM 1, a progressive decrease in the ability of [3H]MTX to subsequently displace the drug was observed. When MTX itself was used at the same concentrations, the extent of displacement of [3H]MTX did not decrease with time. These results were consistent with rapid reversible binding of 1 to the enzyme, followed more slowly by covalent bond formation near the active site. The pH profile for this effect followed a curve with a sigmoidal shape. The apparent inflection point near pH 7.2 was consistent with alkylation of a histidine residue.
Effect of Pyrimethamine and Sulfadiazine on the Fine Structure and Multiplication of Toxoplasma gondii in Cell Cultures (1975)

Rhesus monkey kidney cell cultures were inoculated with Toxoplasma gondii organisms obtained from peritoneal fluid of mice infected with the RH strain. Pyrimethamine and sulfadiazine were added either singly or in combination to the cultures 4 hr after inoculation. Twenty-four hours later the effect of the drugs on the parasites were studied by light and electron microscopy. Pyrimethamine (1.0 mug/ml) inhibited multiplication of the parasites and caused striking morphological changes. Organisms were rounded and often had a fragmented nucleus. Division was inhibited as indicated by abnormal daughter membrane formation during endodyogeny. No effect was evident in sulfadiazine-treated parasites when concentrations up to 50 mug/ml were used. However, combination of ineffective levels of pyrimethamine (0.1 mug/ml) and sulfadiazine (0.5 mug/ml) produced effects similar to those seen at a higher concentration of pyrimethamine indicating a synergistic action of the 2 drugs.
Efficient calculation of the free-space periodic Green's function (1990)

Electromagnetic scattering from periodic structures can be formulated in terms of an integral equation that has as its kernel a periodic Green's function. The periodic Green's function can be derived as a response to an array of line/point sources (spatial domain) or as a response to series of current sheets (spectral domain). These responses are a Fourier transform pair and are slowly convergent summations. The convergence problems in each domain arise from unavoidable singularities in the reciprocal domain. A method is discussed to overcome the slow convergence by using the Poisson summation formula and summing in a combination of spectral and spatial domains. A parameter study is performed to determine an optimum way to weigh the combination of domains. simple examples of scattering from a one-dimensional array of strips and two-dimensional array of plates are used to illustrate the concepts.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Dual photoemissions from the room temperature solutions of the tetranuclear copper(I) clusters Cu4I4(py-X)4(py-X = substituted pyridine) (1989)

The time-resolved emission spectra of the tetranuclear clusters Cu4I4(py-X)4(X = H, 3-Cl, 4-Ph, 4-PhCH2, or 4-But) at 296 K in toluene each display separate, uncoupled emissions from two states, a short-lived (0.13–0.56 µs) metal-to-ligand charge transfer in the range 473–537 nm and a much more intense and longer lived (10–13 µs) metal cluster centred (MCC) emission in the range 678–698 nm; for X = 4-Ph the MCC emission exhibits an unusual, temperature dependent rise-time.
Kinetic Analysis of Secretory Protein Traffic and Characterization of Golgi to Plasma Membrane Transport Intermediates in Living Cells (1998)

Quantitative time-lapse imaging data of single cells expressing the transmembrane protein, vesicular stomatitis virus ts045 G protein fused to green fluorescent protein (VSVG-GFP), were used for kinetic modeling of protein traffic through the various compartments of the secretory pathway. A series of first order rate laws was sufficient to accurately describe VSVG-GFP transport, and provided compartment residence times and rate constants for transport into and out of the Golgi complex and delivery to the plasma membrane. For ER to Golgi transport the mean rate constant (i.e., the fraction of VSVG-GFP moved per unit of time) was 2.8% per min, for Golgi to plasma membrane transport it was 3.0% per min, and for transport from the plasma membrane to a degradative site it was 0.25% per min. Because these rate constants did not change as the concentration of VSVG-GFP in different compartments went from high (early in the experiment) to low (late in the experiment), secretory transport machinery was never saturated during the experiments. The processes of budding, translocation, and fusion of post-Golgi transport intermediates carrying VSVG- GFP to the plasma membrane were also analyzed using quantitative imaging techniques. Large pleiomorphic tubular structures, rather than small vesicles, were found to be the primary vehicles for Golgi to plasma membrane transport of VSVG-GFP. These structures budded as entire domains from the Golgi complex and underwent dynamic shape changes as they moved along microtubule tracks to the cell periphery. They carried up to 10,000 VSVG-GFP molecules and had a mean life time in COS cells of 3.8 min. In addition, they fused with the plasma membrane without intersecting other membrane transport pathways in the cell. These properties suggest that the post-Golgi intermediates represent a unique transport organelle for conveying large quantities of protein cargo from the Golgi complex directly to the plasma membrane.
Prognostic Significance of Early Response to a Single Dose of Asparaginase in Childhood Acute Lymphoblastic Leukemia (1999)

All three asparaginase preparations produced equivalent LCKs in in vitro and in vivo analyses. In vitro response to asparaginase provided a risk group-independent prognostic factor.
Recent developments in hydrocarbon separator interface imaging (2001)

Level monitoring instrumentation is an essential part of hydrocarbon processing facilities, and has together with separator technology been widely addressed over the last decade. Key issues are production capacity, product enhancement and well- flow control. The reliability and accuracy of the level instrumentation, and its ability to monitor the thickness of the foam and the oil-water emulsion, are particularly important when considering the level instrumentation as the main sensing element in the automatic control of the separation vessel. Lately industry focus has been placed on optimal automatic control to improve the quality of the production output, and to minimize the use of expensive and environmentally undesirable separation enhancing chemicals. Recent developments in hydrocarbon production includes subsea separation stations, where the constraints placed on the reliability and accuracy of the level instrumentation are especially severe. This paper discuss the most common existing level monitoring technologies, and present some recent level monitoring developments for three-phase separators. In order to clarify the issue of cross sectional metering the notion tomometry is introduced in this paper. Tomometry denotes multipoint cross sectional metering aiming to acquire cross sectional information on the distribution of the substances in the process vessel for control purposes, not mainly to create a cross sectional reconstructed image of the process in question.
Stereospecific transformation of 2,2-dimethylcyclobutanols into optically active 1,2-cis-disubstituted cyclopropanes (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific transformation of 2,2-dimethylcyclobutanols into optically active 1,2-cis-disubstituted cyclopropanesMartin Karpf and Carl DjerassiCite this: J. Am. Chem. Soc. 1981, 103, 2, 302–306Publication Date (Print):January 1, 1981Publication History Published online1 May 2002Published inissue 1 January 1981https://pubs.acs.org/doi/10.1021/ja00392a009https://doi.org/10.1021/ja00392a009research-articleACS PublicationsRequest reuse permissionsArticle Views195Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts