gebhart/patrepeval huggingface dataset:
Sap R/3 Process-Oriented Implementation: Iterative Process Prototyping (1998)

This book puts forward a method (Iterative Process Prototyping) for defining a company's business process and their interconnectinos so the R/3 system can be modeled accordingly. Because R/3 is a single, corporate wide system it must be set up to reflect the way a company does business.
ChemInform Abstract: S‐TRIAZINE DERIVATIVES. 1. INTERACTION OF 2‐CHLORO‐4,6‐DIMETHOXY‐S‐TRIAZINE WITH ETHYL SODIOMALONATE (1980)

Abstract Das Chlor‐dimethoxy‐triazin (I) reagiert mit Natriummalonsäurediethylester (II) in Dimethylformamid zu einem Gemisch verschiedener Verbindungen (III)‐(VI).
Camilo José Cela, La palabra en libertad: homenaje a Camilo José Cela (1992)

Es resena de: La palabra en libertad : homenaje a Camilo Jose Cela.Comision V Centenario, 1991. ISBN 84-404-9934-5
Specific immunity to human papilloma virus (HPV) in patients with genital warts. (1978)

A study of human papilloma virus (HPV) specific cellular and humoral immunity in 30 patients with genital warts is reported. By in vivo testing with purified, inactivated plantar wart virus, a cell-mediated immunity to HPV was determined in 60% of patients. Circulating antibodies, evaluated by immunofluorescence testing, were rare, but these increased after an intradermal test had been carried out, especially in patients with a positive skin test, suggesting a booster effect. No significant difference was found between this group of patients and those having skin warts. Our results showed a specific immune response to HPV in most patients, confirming the role of the viral agent in the induction of genital warts.
Integration of High‐Conductivity Graphite Foam to Metallic Systems Using Ag‐ <scp>C</scp> u‐ <scp>T</scp> i and <scp>A</scp> g‐ <scp>C</scp> u‐ <scp>P</scp> d Braze Alloys (2013)

Graphite foams with low, medium, and high densities were joined to C u‐clad‐ M o, 430 stainless steel, titanium, and I nconel 625 using C usil‐ ABA ® and P alcusil‐5 ® . Copper‐clad‐molybdenum and steel were also joined to S i C ‐coated foam. Well‐bonded joints with partially infiltrated foam and with carbon ligaments enriched with T i formed in C usil‐ ABA joints of coated and uncoated foam. Low‐density foams showed greatest braze penetration and penetration distance decreased with increasing foam density. Foam/metal joints with P alcusil‐5 showed less penetration than C usil‐ ABA . The tension test on foam/ C u‐clad‐ M o and foam/430 stainless steel joints made using C usil‐ ABA revealed that the joints were always stronger than the foam.
Evaluation of the performance of DEM interpolation algorithms for LiDAR data (2009)

Airborne light detection and ranging (LiDAR) is one of the most effective means for high quality terrain data acquisition. The high-accuracy and high-density LiDAR data\nmakes it possible to model terrain surface in more detail. Using LiDAR data for DEM generation is becoming a standard practice in the spatial science community. Of the three commonly used digital elevation models (e.g., triangular irregular network (TIN), gridded DEM and contour line model), the gridded DEM is the simplest and the most efficient approach in terms of storage and manipulation. However, this approach is liable to introduce errors because of its discontinuous representation of the terrain surface based on the interpolation process of sampled terrain points. Given the characteristics of LiDAR data, much attention must be paid to the selection of an appropriate interpolation algorithm, otherwise the accuracy of produced DEM from LiDAR data will be compromised. This study aims to evaluate the performance of commonly used interpolation algorithms to the LiDAR data, including inverse distance weighted (IDW) method, Kriging method, and local polynomial method. All these interpolation algorithms are applied to DEMs generated from LiDAR at various data density levels. The performance of these interpolation methods is evaluated by using both cross-validation and validation test methods. The results showed the performance of each interpolation algorithm for two study sites with different terrain types and analysed the relationship between interpolation algorithms and LiDAR data density. Considering accuracy and computing time for large volume of LiDAR data, IDW is recommended for LiDAR DEM generation from this study.
Neutral metalloendopeptidase in human male genital tract. Comparison to angiotensin I-converting enzyme. (1985)

High concentrations of neutral metalloendopeptidase (NEP) (enkephalinase) were found in human male genital tract immunohistochemically and by enzyme activity assays, and its distribution was compared with that of angiotensin-converting enzyme (ACE) (kininase II). Whereas the two enzymes colocalize on the luminal aspect of proximal tubular epithelium and are not found elsewhere in the nephron, their distribution in the male genitalia is different. Seminal fluid is rich in NEP and ACE, but after ultracentrifugation ACE remains soluble while NEP sediments. NEP activity is low in testicular homogenate but high in the particulate fraction of epididymides and prostates. ACE, on the other hand, is active in the particulate fraction of testes and in the soluble fraction of epididymides and prostates. Prostatic NEP had a slightly higher molecular weight than the renal NEP, which was reduced by neuraminidase in electroblotting. Testicular and seminal plasma ACE also had a slightly higher molecular weight than the purified renal enzyme (150,000), probably caused by removal of an "anchor" peptide during purification. In the prostate, NEP was found by three different immunohistochemical techniques in luminal epithelial cells and in lumina. The function of NEP in the genital tract may be related to sperm maturation and proacrosin activation.
The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multi‐drug transporter (1993)

The MDRI protein is an energy-dependent transport protein responsible for the multi-drug resistance seen in many tumors. A variety of drugs have been shown to inhibit the function of this pump, including compounds known to block various ion channels. The mouse lymphoma cell line L5178Y has been transduced with the human mdrI gene. Using this cell line, we have tested a number of compounds to determine whether there is a correlation between the ability to block a specific type of ion channel, or shift membrane potential, and the ability to act as an MDR-reversing agent using the fluorescent substrates Rhodamine 123 and daunorubicin as test compounds. Our results show no apparent correlation between the ability to block a specific ion channel and reversal of MDR transport ability. We have found active MDR inhibitors in compounds that affect K+, Na+, Ca++, H+, but not Cl- channels. Our data suggest that Cl- channel activity may be distinct from MDR activity. Several immunosuppressive compounds and analogs were also tested and found to be active reversing agents. Measurements suggest a significant difference in resting membrane potential between the L5178YvMDR line and the L5178Y parental cell line used in these experiments. No correlation was found between the ability of drugs to alter membrane potential and to inhibit MDR transport activity. Our results suggest that MDR transport function may be independent of the physiological movement of ions and show that a wide variety of compounds can inhibit MDR transport.
Introducing Real Time Communication: Frames, modes & rules (2010)

The paper reports on the implementation of Lotus® Sametime® in a large financial services company. The paper uses the distinction of application and infrastructure view to elaborate on distinct modes of RTC use. Moreover, it provides a classification of managerial tasks and responsibilities and reflects on the balancing act of the managerial dictum and space for experimentation and organizational learning. The case highlights organizational design choices as well as managerial challenges. It provides rich insights into the processes of organizational embedding and rule setting, complemented by individual appropriation and self-organization on a group level. Processes of managerial and organizational alignment unfold against the backdrop of the dynamics of implementation.
Co-transfection of MDR1 and MRP antisense RNAs abolishes the drug resistance in multidrug-resistant human lung cancer cells. (1998)

The resistance of lung cancer cells to the therapeutic actions of anticancer drugs is a serious clinical problem often encountered during cancer chemotherapy. It is very important, therefore, to investigate how to prevent and/or reverse this drug resistance. To this end, we took advantage of the fact that the overexpression of MDR1 and MRP genes, two genes known to be associated with the development of drug resistance, is very common in lung cancer. We used antisense RNA in an attempt to prevent expression of the protein products of these genes. Using a retrovirus, we introduced the antisense RNAs of MDR1 and MRP genes into doxorubicin-selected, multidrug-resistant GAOK cells, a cell which overexpresses both MDR1 and MRP genes. The expression levels of the products of the MDR1 gene (Pgp) and MRP gene (Mrp) in the transfected cells were analyzed using flow cytometry, and the drug resistances of the transfected cells were detected by a cell viability (MTT) assay. The expression of Pgp and Mrp in the transfected cells was almost completely inhibited by the antisense RNAs: expression levels decreased 64% and 93%, respectively. In parallel, the drug resistance of these cells decreased about 99% to doxorubicin, 98% to vinblastine, and 97% to colchicine. These results show that: a) antisense RNAs can attenuate drug resistance, an inhibition that might lead to new treatments for patients who are, or become, refractory to conventional chemotherapy; b) MDR1 and MRP appear to be cooperating to confer drug resistance in GAOK cells.
Polyacrylamide Hydrogels: An Effective Tool for Delivering Liquid Baits to Pest Ants (Hymenoptera: Formicidae) (2014)

Ant management in urban and natural areas often relies on toxic baits. Liquid baits are highly attractive to pest ants because they mimic natural food sources such as honeydew and nectar, the principal dietary components of many ants. However, liquid bait use has been limited owing to the lack of bait dispensers that are effective, inexpensive, and easy to service. The current study evaluated the potential of water-storing crystals (polyacrylamide spheres) to effectively deliver liquid thiamethoxam baits to laboratory colonies of Argentine ants, Linepithema humile Mayr. Results of laboratory trials show that bait crystals saturated in 25% sucrose solution containing 0.007% thiamethoxam are highly attractive to Argentine ants and highly effective against all castes and life stages, including workers, queens, and brood. Fresh bait crystals were highly effective and required approximately 2 d to kill all workers and approximately 6 d to achieve complete mortality in queens and brood. Results of bait aging tests show that the crystals lose approximately 70% of moisture in 8 h and the duration of outdoor exposure has a significant effect on moisture loss and subsequently bait acceptance and bait efficacy. A gradual decrease in mortality was observed for all castes and life stages as bait age increased. In general, fresh baits and those aged for < 8 h retained their efficacy and caused substantial mortality. Baits aged longer than 8 h were substantially less attractive and less effective. Horizontal transfer tests examined the transfer of thiamethoxam from live treated donors to live untreated recipients. The results show that donor ants that obtain thiamethoxam by feeding on bait crystals effectively transfer it to untreated recipient ants. The level of secondary mortality depended on the donor:recipient ratio, with approximately 40% recipient worker mortality with the 1:5 ratio and 15% recipient worker mortality with 1:10 or 1:20 ratios. However, no queens died in any transfer tests, suggesting that multiple feedings from multiple donors may be necessary to produce queen mortality. The results of the transfer tests demonstrate the role of trophallaxis in the distribution of thiamethoxam and confirm that thiamethoxam is effectively transferred in Argentine ant colonies. The distribution of thiamethoxam within Argentine ant colonies was further examined using protein marking coupled with an enzyme-linked immunosorbent assay to detect the marker. The distribution of thiamethoxam was highly efficient, with 79 +/- 13% of workers testing positive at 15 min and 100 +/- 0% of workers testing positive at 6 h. In summary, the results of this study demonstrate that water-storing crystals effectively deliver thiamethoxam to all castes and life stages of Argentine ants and may offer an effective tool for Argentine ant management.
Practical Considerations in Optimal Flight Management Computations (1985)

The relationships between cost index, speed, flight time, fuel burn, and wind are investigated via simulations of flight of a DC-10 aircraft, as controlled by a flight management computer system (FMCS), over a representative 1000 NM flight plan. In this context, a two-part procedure is described for achieving minimum total flight cost; that is, direct operating cost plus arrival error cost. First the optimum cost index and the associated optimum arrival time (which sometimes turns out to be the scheduled arrival time) are sought. A simple method for fine tuning the speed to achieve the desired arrival time is then described. The methods are practical to incorporate in the FMCS.
Visualization Bio-Mimetic Model of Muscular Drive (2007)

There exist large numbers of papers on muscle modeling for biomechanics or virtual reality but, in our opinion, they are inconvenient as a practicable method for muscular drive modeling for robotic joint or bio-mechanisms. We now propose a computational approach to modeling artificial muscle for robotic joint or bio-mechanisms drive. In the full paper, we explain in detail the proposed efficient method; in this abstract we just summarize briefly how we developed our visualization muscular drive model. This paper advocates a two-element model representing the complex mechanical properties of artificial muscles, the model utilizes Zajac's method and neglects the effect of series elastic element, in addition, its three-dimensional geometry entity is designed. In order to build this muscle model rapidly, a software plugin is developed based on ADAMSTM that allows the creation of control module and multi-body dynamic system for use in bio-mechanisms. As an example, a bio-mimetic joint actuator for robots comprising four muscle models is built and analyzed. The results show that our visualization model of muscular drive has good simplicity and accuracy.
Spatial Correlation between Hyperpigmentary Changes on Color Fundus Photography and Hyperreflective Foci on SDOCT in Intermediate AMD (2012)

A novel algorithm achieves automated intermodality spatial coregistration for masked grading of regions selected on CFP and SDOCT. In intermediate AMD, macular hyperpigmentation has high spatial correlation to SDOCT hyperreflective foci and often represents the same anatomical lesion. (ClinicalTrials.gov number, NCT00734487.).
Fault detection effectiveness of source test case generation strategies for metamorphic testing (2018)

Metamorphic testing is a well known approach to tackle the oracle problem in software testing. This technique requires the use of source test cases that serve as seeds for the generation of follow-up test cases. Systematic design of test cases is crucial for the test quality. Thus, source test case generation strategy can make a big impact on the fault detection effectiveness of metamorphic testing. Most of the previous studies on metamorphic testing have used either random test data or existing test cases as source test cases. There has been limited research done on systematic source test case generation for metamorphic testing. This paper provides a comprehensive evaluation on the impact of source test case generation techniques on the fault finding effectiveness of metamorphic testing. We evaluated the effectiveness of line coverage, branch coverage, weak mutation and random test generation strategies for source test case generation. The experiments are conducted with 77 methods from 4 open source code repositories. Our results show that by systematically creating source test cases, we can significantly increase the fault finding effectiveness of metamorphic testing. Further, in this paper we introduce a simple metamorphic testing tool called "METtester" that we use to conduct metamorphic testing on these methods.
Functional analyses of the eyelid skin constituting the most soft and smooth area on the face: contribution of its remarkably large superficial corneocytes to effective water‐holding capacity of the stratum corneum (2007)

Our present biophysical findings suggest that, although the eyelid skin is poor in surface lipids, its extraordinary large superficial corneocytes play an important role in maintaining sufficient hydration state of its skin surface to keep it soft and flexible, enabling its good compliance with the blinking movement.
General Diffraction Theory of Optical Aberration Tests, from the Point of View of Spatial Filtering (1969)

A general theory of optical-aberration tests, encompassing many well-known practical tests, is presented, utilizing the formalism of spatial filtering, employing coherent illumination. The basic diffraction integrals of the Ronchi-grating test, Foucault knife-edge test, phase Foucault knife-edge test, and the Zernike phase-contrast test are derived. Typical situations have been analyzed and numerical results are shown and discussed.
Regulation of chemokine-induced transendothelial migration of T lymphocytes by endothelial activation: differential effects on naive and memory T cells (2000)

Human T lymphocyte transendothelial migration (TEM) was examined in response to chemokines across cytokine-activated endothelium. Monocyte chemotactic protein-1 (MCP-1), RANTES, and macrophage inflammatory protein-1alpha (MIP-1alpha) induced TEM by memory T cells, while stromal cell-derived factor-1 (SDF-1) induced TEM by both naive and memory T cells. Tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) increased endothelial adhesion molecule (CAM) expression, whereas interferon-gamma (IFN-gamma) induced little up-regulation of CAM. However, both TNF-alpha and IFN-gamma strongly facilitated T cell migration, which was completely inhibited by pertussis toxin and both greatly increased TEM to RANTES, MIP-1alpha, and SDF-1 selectively of memory but not naive T cells. Thus, the dual selective effect on memory T cells of endothelial activation and these chemokines promotes the preferential recruitment of memory T cells to inflammatory sites. However, the enhanced chemokine-induced migration by memory T cells across activated endothelium appears to be independent of the increase in endothelial CAM expression. G-protein-linked stimuli may play an important part in T cell TEM across cytokine-activated endothelium.
Phase-shifting speckle interferometry: a noise reduction filter for phase unwrapping (1997)

We present a noise reduction filter for the phase unwrapping of data from phase-shifting speckle pattern interferometry. This filter is effective in reducing the noise in wrapped phase maps without affecting the edges of the phase jumps, so that a simple and fast unwrapping algorithm can be used. We also discuss a data analysis strategy, includ- ing a routine for the recovery of unwrapping errors. The filter perfor- mance has been evaluated on real data from a fiber optic phase-shifting speckle interferometer, which we built for the analysis of out-of-plane deformations. The phase shifting is introduced by current modulation of the diode laser source. Some results relative to the analysis of very noisy phase measurements are presented. © 1997 Society of Photo-Optical Instru- mentation Engineers. (S0091-3286(97)01209-9)
Biosynthesis of 4‘-<i>O</i>-Methylpyridoxine (Ginkgotoxin) from Primary Precursors (1999)

Cell suspension cultures of Ginkgo biloba and Albizia tanganyicensis were investigated for the presence of 4'-O-methylpyridoxine (ginkgotoxin, 2), the 4'-O-methyl derivative of vitamin B(6) (pyridoxine, 1). The cultures produced the toxin even in the absence of vitamin B(6) (a common additive to plant cell culture media). This indicates that the pyridoxine ring system of ginkgotoxin is synthesized de novo by the cultured cells. A feeding experiment with D-[U-(13)C(6)]glucose revealed that the mode of incorporation of label into the pyridoxine moiety of 2 matched that observed for 1 in Escherichia coli. Thus, the data obtained in this investigation provide independent proof supporting the current hypothesis on vitamin B(6) biosynthesis. The 4'-O-methyl group of ginkgotoxin (2) was labeled from L-[methyl-(13)C(1)]methionine. This indicates that ginkgotoxin is likely to be derived by 4'-O-methylation of pyridoxine (1). The G. biloba cell suspension culture may be a suitable system to get further insight into vitamin B(6) and/or ginkgotoxin biosynthesis.
Purification and characterization of sulfotransferase specific to O-22 of 11-hydroxy saxitoxin from the toxic dinoflagellate Gymnodinium catenatum (dinophyceae) (2002)

A novel sulfotransferase (O-ST), which transferred the sulfate group of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to O-22 of 11-α, β-hydroxy saxitoxin (STX) and produced GTX2+3, was purified to homogeneity from the cytosolic fraction of clonal-axenic vegetative cells of the toxic dinoflagellate Gymnodinium catenatum GC21V. After four purification steps, including affinity chromatography and anion exchange chromatography, the enzyme was purified 500-fold and the yield was 4%. On affinity chromatography with a PAP-agarose column, O-ST was observed in the bound fraction, and N-ST specific to N-21 of STX and GTX2+3 was found in the unbound fraction. The molecular mass of the purified enzyme was determined by sodium dodecylsulfate polyacrylamide gel electrophoresis (SDS-PAGE) to be 65 kDa. Gel filtration chromatography showed a native molecular mass of 67 kDa, indicating that O-ST is a monomeric enzyme. The enzyme was optimally active at pH 6.0 and 35°C. O-ST did not require metal cations for its activity. O-ST required PAPS as the sole source of sulfate. O-ST transferred a sulfate group from PAPS to only O-22 of 11-α, β-hydroxy STX and not to N-21 of these toxins. These observations suggested that two ST, N-ST and O-ST, participate in the sulfation of PSP toxins.
Isolation and identification of equol-producing bacterial strains from cultures of pig faeces (2008)

Transformation of daidzein to equol was compared during fermentation of three growth media inoculated with faeces from Erhualian piglets, but equol was produced from only one medium, M1. Two equol-producing strains (D1 and D2) were subsequently isolated using medium M1. Both strains were identified as Eubacterium sp., on the basis of morphological and physiological characteristics, and 16S rRNA gene sequence analysis showed that strains D1 and D2 were most closely related to previously characterized daidzein-metabolizing bacteria isolated from human faecal and rumen samples, respectively. This suggests that the ability to metabolize daidzein can be found among bacteria present within the mammalian intestine. The results provided the first account of conversion of daidzein directly to equol by bacterial species from farm animals. These strains may be of importance to the improvement of animal performance, and the use of medium M1 could provide a simple way to isolate bacterial strains capable of transforming daidzein into equol.