gebhart/patrepeval huggingface dataset:
Angiogenesis at the Interface between Basic and Clinical Research (1999)

The field of antiangiogenesis has shown a remarkably rapid evolution from the discovery at the bench to translation into the clinic. Currently a wide variety of compounds are in clinical trial as inhibitors of angiogenesis, and new compounds are being frequently added. The target cell of most angiogenesis inhibitors is the endothelial cell, with inhibitors that selectively affect a number of endothelial cell functions acquired during angiogenesis, including activation, proliferation, migration, invasion and survival. The endothelial cell may also be targeted by chemotherapeutic agents currently in use. The high doses and intermittent treatment schedules used to fight resistant tumor cells may be altered towards lower doses and chronic administration to obtain selective inhibition of angiogenic factor-stimulated endothelial cells as adjuvant therapy. Finally, gene therapy is a promising route for the delivery of novel protein inhibitors of angiogenesis, and is actively being investigated.
Who? What? When? Using a timeline technique to facilitate recall of a complex event. (2013)

Accurately recalling a complex multi-actor incident presents witnesses with a cognitively demanding retrieval task. Given the important role played by temporal context in the retrieval process, the current research tests an innovative timeline technique to elicit information about multiple perpetrators and their actions. Adopting a standard mock witness paradigm, participants were required to provide an account of a witnessed event. In Experiment 1, the timeline technique facilitated the reporting of more correct details than a free recall, immediately and at a two-week retention interval, at no cost to accuracy. Accounts provided using the timeline technique included more correct information about perpetrator specific actions and fewer sequencing errors. Experiment 2 examined which mnemonic components of the timeline technique might account for these effects. The benefits of exploiting memory organization and reducing cognitive constraints on information flow are likely to underpin the apparent timeline advantage.
O PAPEL DA MEMÓRIA NA ESCRITA AUTOBIOGRÁFICA (2016)

GARCIA, Celina Fontenele. O papel da memória na escrita autobiográfica. Rev. de Letras, Fortaleza, v. 25, n. 1/2, p. 15-24, jan./dez. 2003.
Influenza Vaccination and Vitamin K Antagonist Treatment (2010)

clinicaltrials.gov Identifier: NCT00222638.
Comparative profiling analysis of woody flavouring from vine‐shoots and oak chips (2013)

Statistical analysis enabled demonstration of the similarity among extracts from vine shoots and oak wood, providing the first study on this subject. The special role of phenols and furanic derivatives has been described. This study is the first stage for characterization of vine shoots as a by-product with potential for use in the oenological field.
Tolerance intervals for accuracy control of bootstrapped matched filters (2002)

We consider the problem of designing detectors using tolerance intervals. Signal detection based on tolerance intervals allows us to force the actual level of significance not to exceed the preset level with a given probability. The results presented in this letter demonstrate the accuracy with which these detectors can control the false-alarm rate when little is known about the noise distribution and only a small sample is available.
α/3<sub>10</sub>‐Helix transitions in α‐methylalanine homopeptides: Conformational transition pathway and potential of mean force (1994)

The conformational transition between the alpha- and 3(10)-helical states of alpha-methylalanine homopeptides is studied with molecular mechanics. Conformational transition pathways for Ace-(MeA)n-NMe with n = 7, 9, and 11 are obtained with the algorithms of Elber and co-workers [R. Czerminski & R. Elber (1990) International Journal of Quantum Chemistry, Vol. 24, pp. 167-186; A. Ulitsky & R. Elber (1990) Journal of Chemical Physics, Vol. 92, pp. 1510-1511]. The free energy surface, or potential of mean force, for the conformational transition of Ace-(MeA)9-NMe is calculated from molecular dynamics simulations, and a method is presented for the decomposition of the free energy surface into the constituent energetic and entropic terms, via the calculation of the required temperature derivatives in situ. For the AMBER/OPLS model employed here, the conformational transition pathways each contain a single 3(10)-helical-like transition state, and the transition state potential energy relative to the 3(10)-conformation is 3 kcal/mol, independent of peptide length. Entropic stabilization in the barrier region significantly lowers the activation free energies for the forward and reverse transitions from the estimates of the barrier heights based simply on potential energy alone.
Thermal, spectroscopic, and dissolution studies of the simvastatin–acetylsalicylic acid mixtures (2012)

The objective of the present investigation was to study the effect of eutectic formation on in vitro dissolution of simvastatin (SIM) released from mixtures with acetylsalicylic acid (ASA) prepared by a grinding method. SIM–ASA mixtures were characterized by means of differential scanning calorimetry (DSC), infrared spectroscopy (IR), X-ray powder diffractometry (XRPD), and in vitro dissolution tests. IR spectroscopy and XRPD studies indicated no interaction between SIM and ASA in the solid state. The DSC investigation has revealed that SIM and ASA form a simple eutectic system containing 66.6 % w/w of SIM at the eutectic point. In vitro dissolution studies of SIM and its mixtures with ASA were carried out. The eutectic mixture shows an appreciable increase in the dissolution rate in comparison with other ratios and SIM in 0.5 % w/v sodium lauryl sulfate. The dissolution enhancement of SIM was related to the effective wetting of the drug particles with a significantly reduced size released from eutectic composition. In conclusion, dissolution of SIM can be enhanced through eutectic formation with ASA by means of simple mechanical activation (a grinding method).
Design and Implementation of Stored Procedure Router Based on Dynamic SQL (2009)

The stored procedure router is designed to dynamically call stored procedure. It is based on dynamic SQL and coded by PL/SQL. Two tables are established according to stored procedure table and stored procedure parameter table before stored procedure router is called. The caller gets input and output parameters of stored procedure by visiting two tables, without direct contact stored procedure itself. Inputting stored procedure number and parameters can obtain result of executing stored procedure. Dynamic SQL statement based on these parameters is designed and executed. Input parameters and output parameters are bind the corresponding variables which begin to the colon in SQL statement.When invoking stored procedure coded by PL/SQL, it is convenient to use stored procedure router. Only modify content of table when stored procedure changes. It brings a great facilitate to secondary development staff and accelerate the system design process, improve the system design performance.
Host-defence-related proteins in cows’ milk (2011)

Milk is a source of bioactive molecules with wide-ranging functions. Among these, the immune properties have been the best characterised. In recent years, it has become apparent that besides the immunoglobulins, milk also contains a range of minor immune-related proteins that collectively form a significant first line of defence against pathogens, acting both within the mammary gland itself as well as in the digestive tract of the suckling neonate. We have used proteomics technologies to characterise the repertoire of host-defence-related milk proteins in detail, revealing more than 100 distinct gene products in milk, of which at least 15 are known host-defence-related proteins. Those having intrinsic antimicrobial activity likely function as effector proteins of the local mucosal immune defence (e.g. defensins, cathelicidins and the calgranulins). Here, we focus on the activities and biological roles of the cathelicidins and mammary serum amyloid A. The function of the immune-related milk proteins that do not have intrinsic antimicrobial activity is also discussed, notably lipopolysaccharide-binding protein, RNase4, RNase5/angiogenin and cartilage-glycoprotein 39 kDa. Evidence is shown that at least some of these facilitate recognition of microbes, resulting in the activation of innate immune signalling pathways in cells associated with the mammary and/or gut mucosal surface. Finally, the contribution of the bacteria in milk to its functionality is discussed. These investigations are elucidating how an effective first line of defence is achieved in the bovine mammary gland and how milk contributes to optimal digestive function in the suckling calf. This study will contribute to a better understanding of the health benefits of milk, as well as to the development of high-value ingredients from milk.
Microstructural origin of soft magnetic properties of sendust films prepared by N2 reactive sputtering (1998)

Sendust films were deposited using dc magnetron sputtering at room temperature in a mixture of Ar and N2 gas. The soft magnetic properties of the sendust films were, in general, improved with the addition of N2. The optimum soft magnetic properties were achieved when 6% N2 gas was used. Transmission electron microscopy studies showed that the sendust film without N2 contains average grain sizes of 200 nm; whereas the films with increasing N2 content contain increasing percentages of much smaller grains of 20 nm. The smaller grains have a random crystalline orientation with respect to each other. The cross-sectional morphological structures were studied using a scanning electron microscope. In the film without N2, power-law cone structures were observed. In the N2 containing films, needlelike morphological structures were formed. X-ray photoelectron spectroscopy studies on these films indicate that N2 included in the films reacts preferentially with Al to form AlN. Excess N2 may then react with Si, possibly to form Si3N4. The atomic concentrations of Al and N become equal in the films when 6% N2 was used, which also gives rise to the optimum soft magnetic properties. To understand the advent of soft magnetic properties, a random magnetic anisotropy model and a static wall coercive force model were considered.
Spatial and polarization characterization of MIMO channels in rural environment (2005)

An extensive campaign to characterize the multi-antenna radio propagation channel between two ground based platforms was conducted in a rural area of Lakehurst, NJ. Dozens of links with ground level transmitter and receiver arrays were characterized in mixed wooded/open terrain over ranges of up to 4 km. MIMO capacity was computed for an 8/spl times/10 MIMO system using the measured H-matrices. It was found that median 8/spl times/10 MIMO capacity supported by the channel was about 8 times the corresponding 1/spl times/1 capacity, and 3.2 times the corresponding 1/spl times/10 capacity. It was found that using arrays containing antennas of both horizontal and vertical polarizations improves capacity for short range LOS channels by almost fifty percent.
A canonical representation for distributions of adaptive matched subspace detectors (2002)

We present a unified derivation of the distributions for adaptive versions of matched subspace detectors (MSDs) derived by Scharf (see Statistical Signal Processing, Addison-Wesley, and IEEE Trans. Signal Processing, 1996). These include: (1) the matched filter detector, (2) the gain invariant (CFAR) matched filter detector (3) the phase invariant matched subspace detector, and (4) the gain invariant (CFAR) and phase invariant matched subspace detector. We show that all these detectors can be decomposed into representations that are simple functions of the same five statistically independent, chi-squared or normal, scalar random variables. This canonical representation has at least three advantages: (1) the behavior of these detectors can easily be related to that of the non-adaptive detectors from which they are derived (2) moments can be simply obtained from the distributions of the scalar random variables, and (3) Monte Carlo simulations of the distributions can be implemented more efficiently.
Immunomagnetic Purging of Lymphoma Cells from Autografts (1996)

This report describes experiences at the Norwegian Radium Hospital in immunomagnetic purging of lymphoma from autologous stem cell grafts by negative and positive selection. Clinical data from 83 patients who received purged marrow grafts and 3 patients who received purged, mobilized leukapheresis products are presented. Early data indicate that immunomagnetic enrichment of CD34+ cells from leukapheresis products does not routinely achieve effective purging, as 1%-2% residual lymphoma cells could still be detected in the selected grafts.
On-line Energy-based Method for Soil Estimation and Classification in Autonomous Excavation (2007)

This paper proposes a novel approach for soil estimation and classification in autonomous excavation exploiting key features from bucket velocity and energy signatures considering the interaction dynamic of the digging process. A real-time energy-based method is proposed for estimating the dynamic friction force arising during soil-tool interaction. The method relies on a novel technique for measuring the force and displacement variables which allows the on-line determination of the bucket velocity and dissipation energy along the full excavation profile. It is shown that these measurements can be effectively used for the on-line identification and classification of different types of soil encountered during the excavation process. The proposed method is insensitive to noise and can be easily implemented in practice using an excavation arm and hydraulic actuators. Various experimental results are presented supporting the practicality of the proposed method.
Characterization and overproduction of the<i>Escherichia coli</i><i>appA</i>encoded bifunctional enzyme that exhibits both phytase and acid phosphatase activities (1999)

The appA gene that was previously shown to code for an acid phosphatase instead codes for a bifunctional enzyme exhibiting both acid phosphatase and phytase activities. The purified enzyme with a molecular mass of 44 708 Da was further separated by chromatofocusing into two isoforms of identical size with isoelectric points of 6.5 and 6.3. The isoforms had identical pH optima of 4.5 and were stable at pH values from 2 to 10. The temperature optimum for both phytase isoforms was 60°C. When heated at different pH values the enzyme showed the greatest thermal resistance at pH 3. The pH 6.5 isoform exhibited K m and V max values of 0.79 mM and 3165 U·mg -1 of protein for phytase activity and 5.5 mM and 712 U·mg -1 of protein for acid phosphatase, respectively. The pH 6.3 isoform exhibited slightly lower K m and V max values. The enzyme exhibited similar properties to the phytase purified by Greiner et al. (1993), except the specific activity of the enzyme was at least 3.5-fold less than that previously reported, and the N-terminal amino acid sequence was different. The Bradford assay, which was used by Greiner et al. (1993) for determination of enzyme concentration was, in our hands, underestimating protein concentration by a factor of 14. Phytase production using the T7 polymerase expression system was enhanced by selection of a mutant able to grow in a chemically defined medium with lactose as the carbon source and inducer. Using this strain in fed-batch fermentation, phytase production was increased to over 600 U·mL -1 . The properties of the phytase including the low pH optimum, protease resistance, and high activity, demonstrates that the enzyme is a good candidate for industrial production as a feed enzyme.
Intra- and Intercellular Silver Nanoparticle Translocation and Transformation in Oyster Gill Filaments: Coupling Nanoscale Secondary Ion Mass Spectrometry and Dual Stable Isotope Tracing Study (2020)

The extensive application of silver nanoparticles (AgNPs) requires a full examination of their biological impacts, especially in aquatic systems where AgNPs are likely to end up. Despite numerous toxicity studies from molecular to individual levels, it is still a daunting challenge to achieve <i>in situ</i> subcellular imaging of Ag and to determine the sites of AgNP interaction with organelles or macromolecules simultaneously. Here, by coupling high-resolution nanoscale secondary ion mass spectrometry elemental mapping with scanning electron microscopy ultrastructural characterization, we successfully visualized the subcellular localization and the potential toxicity effects of AgNPs in the oyster gill filaments. The stable isotope tracing method was also adopted to investigate the respective uptake and transport mechanisms of differently labeled <sup>109</sup>AgNPs and <sup>107</sup>Ag<sup>+</sup> ions. <sup>109</sup>Ag hotspots were colocalized with endosomes or lysosomes, proving an endocytosis-based entry of AgNPs which passed through the barrier of oyster gill epithelium. These <sup>109</sup>Ag hotspots showed a strong colocalization with <sup>32</sup>S<sup>-</sup>. For the first time, we provided visualized evidence of AgNP-induced autophagy in the oyster gill cells. We further identified two categories of hemocytes (blood cells) and illustrated their roles in AgNP transport and sequestration. The integration of morphological and functional aspects of Ag subcellular distribution in different target cells suggested that oysters were equipped with a specialized endolysosomal (epithelial cells) or phagolysosomal system (hemocytes) in regulating the cellular process of AgNPs, during which the lysosome was the most involved organelle and sulfur was the most relevant macronutrient element. This study highlighted not only the intracellular but also the intercellular AgNP translocation and transformation, providing important subcellular imaging of silver and reliable methodology regarding bio-nano interactions in natural environments.
Structure of a novel glucosamine-containing phosphoglycolipid from Deinococcus radiodurans (1989)

The structure of a major novel lipid from Deinococcus radiodurans has been determined to be 2'-O-(1,2-diacyl-sn-glycero-3-phospho)-3'-O-(alpha-N-acetylglucosaminyl) -N- glyceroyl alkylamine. The lipid was shown to contain a phosphatidic acid backbone by digestion with phospholipase A2 and by hydrolysis with hydrofluoric acid. Using a combination of chemical and NMR spectroscopic techniques, the structure of this lipid was elucidated and compared with that of a similar phosphoglycolipid reported earlier (Anderson, R., and Hansen, K. (1985) J. Biol. Chem. 260, 12219-12223) in which galactose was found in place of N-acetylglucosamine. The fatty acid compositions of the two lipids were similar.
Abstract: Grenvillian inller in the Appalachian Orogen: U-Pb ages from the Blair River Complex, northern Cape Breton Island, Nova Scotia (1993)

The Blair River Complex (BRC) forms the surficial expression of the southeastern part of a promontory on the proto-Atlantic continental margin. In the northern Appalachian Orogen this margin, represented by the Humber Zone, is characterized by Grenvillian basement overlain by a CambroOrdovician, passive-margin sedimentary sequence. The BRC lacks these sedimentary rocks, but has granulite-facies gneiss, syenite, anorthosite, and granitoid orthogneiss, rock types suggestive of Grenvillian basement. U-Pb dating of zircons from the BRC suggest that the igneous protolith of the Sailor Brook gneiss is no younger than 1217 Ma, and that metamo_rphism of this unit occurred at 1035 +12/-10 Ma. Zircon from the Lowland Brook Syenite indicates an igneous age of 1080 +5/-3 Ma. Zircon from a compositionally layered unit of the Red River Anorthosite Complex indicates metamorphism, perhaps accompanied by injection of minor foreign melt, at 996 +6/-5 Ma. The biotiterich, garnet-bearing, granitoid Otter Brook orthogneiss yielded an igneous age of 978 +6/-5 Ma. Comparable ages occur throughout the North American Grenville Province. The effect of a major thermal overprint on the BRC is demonstrated by titanite from seven widely distributed samples, which gave metamorphic ages of ca. 425 Ma. Rutile from the anorthosite complex yielded an age of 410 +2/-3 Ma and likely represents post-metamorphic cooling through 430 to 380°C. Comparisons of rock types and ages best support a Grenvillian origin for the BRC, and the intense, widespread Silurian metamorphism indicates significant involvement in Appalachian orogenesis. These data support inclusion of the BRC in the Humber Zone.
A detailed investigation of circulating IgE levels in a normal population (1975)

Total circulating IgE levels were measured in a carefully selected normal population, using a highly sensitive double antibody assay. The mean level of 36.3 u/ml found in this group is much lower than that reported in all previous studies. No circadian rhythm was evident, but IgE levels varied slightly from day-to-day. IgE levels in 100 serum samples were compared using the double antibody assay and the Phadebas test kit, based on a solid phase technique. A poor correlation was obtained with values below 100 u/ml, however, there was an excellent correlation for samples with IgE levels above this figure.
PAPER CHEMISTRY: Approaching super-hydrophobicity from cellulosic materials: A Review (2013)

The development of super-hydrophobic surfaces has been inspired by natural systems and uses a number of novel (nano) technologies. Superhydrophobicity has stimulated much scientific and industrial interest because of applications in water repellency, selfcleaning, friction reduction, antifouling, etc. Despite its inherent hydrophilicity, cellulose has unparalleled advantages as a substrate for the production of superhydrophobic materials. This is because of its abundance, biodegradability and unique physical, chemical and mechanical properties that compare advantageously with the non-renewable materials typically used. This review includes a comprehensive survey of the progress achieved so far in the production of super-hydrophobic materials based on cellulose. Emphasis is placed on the effects of cellulose surface chemistry and topography, both of which affect hydrophobicity. Overall, this contribution summarizes some of the aspects that are critical to advance this evolving field of science.
Histone H1 expressed in Saccharomyces cerevisiae binds to chromatin and affects survival, growth, transcription, and plasmid stability but does not change nucleosomal spacing. (1994)

Histone H1 is proposed to serve a structural role in nucleosomes and chromatin fibers, to affect the spacing of nucleosomes, and to act as a general repressor of transcription. To test these hypotheses, a gene coding for a sea urchin histone H1 was expressed from the inducible GAL1 promoter in Saccharomyces cerevisiae by use of a YEp vector for high expression levels (strain YCL7) and a centromere vector for low expression levels (strain YCL1). The H1 protein was identified by its inducibility in galactose, its apparent molecular weight, and its solubility in 5% perchloric acid. When YCL7 was shifted from glucose to galactose for more than 40 h to achieve maximal levels of H1, H1 could be copurified in approximately stoichiometric amounts with core histones of Nonidet P-40-washed nuclei and with soluble chromatin fractionated on sucrose gradients. While S. cerevisiae tolerated the expression of low levels of H1 in YCL1 without an obvious phenotype, the expression of high levels of H1 correlated with greatly reduced survival, inhibition of growth, and increased plasmid loss but no obvious change in the nucleosomal repeat length. After an initial induction, RNA levels for GAL1 and H1 were drastically reduced, suggesting that H1 acts by the repression of galactose-induced genes. Similar effects, but to a lower extent, were observed when the C-terminal tail of H1 was expressed.