gebhart/patrepeval huggingface dataset:
Molecular profiling of proteolytic and lectin transcripts in <i>Homalodisca vitripennis</i> (Hemiptera: Auchenorrhyncha: Cicadellidae) feeding on sunflower and cowpea (2007)

Homalodisca vitripennis Germar 1821 (Hemiptera: Cicadellidae) [Takiya et al. (2006) Ann Entomol Soc Am 99:648-655; syn. H. coagulata (Say)] salivary gland and gut EST libraries were used to isolate cDNA fragments of the gene transcripts encoding for cathepsin L, asparaginyl endopeptidase, cathepsin B, metalloendopeptidase, cathepsin D, multicatalytic endopeptidase, and a sugar-binding C-type lectin. Transcript levels were evaluated in immature and adult H. vitripennis feeding on sunflower (Helianthus annuus) or cowpea (Vigna unguiculata). Northern blot hybridization results showed that expression of most of the transcripts were similar for all developmental stages and feeding on the two diets examined. However, the expression of the transcript for asparaginyl endopeptidase was less expressed in sunflower-fed adult females compared to sunflower-fed immatures. Also, the expression of the C-type lectin transcript was up-regulated in adults compared to immatures when fed on either diet. Documenting both the presence and variation of transcript expression involved in putative digestive proteolysis in this xylem-feeding leafhopper is noteworthy and aids efforts to design specific diet formulations for mass production of hosts and parasitoids to be used as effective biological control measures.
Choices in the Implementation of Rating (1997)

Collagenase-treated isolated cells, prepared from epididymal fat pads of Sprague-Dawley rats exposed to 32Pi or (gamma-32P)-ATP, result in differences in label incorporation into peptides as determined by autoradiography of dried SDS polyacrylamide gels. 32Pi-labelled cells respond to epinephrine by increase in labeling of a 67,000-dalton band, presumably the activated lipase. (gamma-32P)-ATP exposed cells gave a dose-dependent increase in a 53,000-dalton band, a finding shared by cells exposed to cAMP in the absence of epinephrine. However, whereas, cAMP also significantly increased the labeling of an 18,000-dalton band, epinephrine had only a minor effect in the labeling of the 18,000-dalton component. Also, the degree of labeling of a 42,000-dalton band is diminished after epinephrine compared to unstimulated cells. By contrast, cAMP does not affect the labeling of the 42,000-dalton component. The localization of the 53,000- and the 18,000-dalton peptides as well as the enzyme(s) that catalyze their phosphorylation on the external surface of the fat cell is supported by studies using a number of macromolecular probes as well as by subcellular fractionation studies. The absence of such phosphopeptides or kinase activity in the infranatants of such cell suspensions eliminates the possibility that these phenomena are the result of leakage of cytoplasmic components. Thus, epinephrine appears to have effect and do not appear to be explicable simply by the release of cAMP to the extracellular compartment.
Evaluation of dynamic electromagnetic tracking deviation (2009)

Electromagnetic tracking systems (EMTS's) are widely used in clinical applications. Many reports have evaluated their static behavior and errors caused by metallic objects were examined. Although there exist some publications concerning the dynamic behavior of EMTS's the measurement protocols are either difficult to reproduce with respect of the movement path or only accomplished at high technical effort. Because dynamic behavior is of major interest with respect to clinical applications we established a simple but effective modal measurement easy to repeat at other laboratories. We built a simple pendulum where the sensor of our EMTS (Aurora, NDI, CA) could be mounted. The pendulum was mounted on a special bearing to guarantee that the pendulum path is planar. This assumption was tested before starting the measurements. All relevant parameters defining the pendulum motion such as rotation center and length are determined by static measurement at satisfactory accuracy. Then position and orientation data were gathered over a time period of 8 seconds and timestamps were recorded. Data analysis provided a positioning error and an overall error combining both position and orientation. All errors were calculated by means of the well know equations concerning pendulum movement. Additionally, latency - the elapsed time from input motion until the immediate consequences of that input are available - was calculated using well-known equations for mechanical pendulums for different velocities. We repeated the measurements with different metal objects (rods made of stainless steel type 303 and 416) between field generator and pendulum. We found a root mean square error (<i>e</i><sub>RMS</sub>) of 1.02mm with respect to the distance of the sensor position to the fit plane (maximum error <i>e</i><sub>max</sub> = 2.31mm, minimum error <i>e</i><sub>min</sub> = -2.36mm). The eRMS for positional error amounted to 1.32mm while the overall error was 3.24 mm. The latency at a pendulum angle of 0° (vertical) was 7.8ms.
Rotational symmetry field design on surfaces (2007)

Designing rotational symmetries on surfaces is a necessary task for a wide variety of graphics applications, such as surface parameterization and remeshing, painterly rendering and pen-and-ink sketching, and texture synthesis. In these applications, the topology of a rotational symmetry field such as singularities and separatrices can have a direct impact on the quality of the results. In this paper, we present a design system that provides control over the topology of rotational symmetry fields on surfaces.
A high performance GPU-based software-defined basestation (2014)

We present a high performance GPU-based software-defined basestation. The key idea is to explore the feasibility of using GPU as a baseband processor for supporting software-defined basestation to achieve both real-time high performance and high reconfigurability, considering the numerous computing resources and flexible programming interface of GPU. Based on an existing WARPLab SDR framework, we put effort on the exploration of the data level parallelism and algorithm level parallelism of baseband kernels for GPU acceleration, as well as the task level parallelism in the system for the task pipelining of packet data transfer and data processing. As a case study, an OFDM system is implemented to better demonstrate the concept of our system architecture and optimization strategies. In this case, our GPU-based basestation can not only achieve less than 3ms latency and more than 50Mbps throughput for processing streaming frames in real-time, but also offer software-defined flexibility and scalability for supporting future wireless standards.
Nanolithography with an atomic force microscope by means of vector-scan controlled dynamic plowing (1999)

We present a nanolithography technique based on an atomic force microscope. A thin resist layer on the sample surface is plastically indented by a vibrating tip. Controlling of the vibration amplitude and tip movement enables one to plow a narrow furrow along line segments of arbitrary length and direction. Different line segments which form a complex pattern can be plowed at a scan speed up to 5 μm/s. The geometric distortion of the resist pattern is less than 50 nm, where at scan speed in excess of 1 μm/s an interrupt of at least 10 ms is necessary between the line segments. The minimum offset error in positioning a pattern with respect to existing features is less than 4% of the scanning field. The patterns are transferred into SiO2, Si, GaAs, Ti, and Au by wet-chemical etching. Minimum linewidth is 25 nm in 1.5 nm oxide layers, 75 nm in 10 nm Ti film and 40 nm in 10 nm Au. On semiconductor surfaces smooth and perfectly shaped V grooves of 55 nm width are obtained.
Mercury Cadmium Telluride/Cadmium Telluride Distributed Bragg Reflectors (2006)

A HgCdTe/CdTe system is investigated for use in distributed Bragg reflectors. The modelled performance is described, and compared to an as-grown structure. As-grown 15 layer structures with arithmetically varying layer thickness are also annealed at 250°C and performance re-evaluated at 2, 7 and 24 hours anneal times. There is some shifting of the absorption edge after annealing , and some degradation in reflectivity, but the mirror is still functioning
Vertically Aligned p-Type Single-Crystalline GaN Nanorod Arrays on n-Type Si for Heterojunction Photovoltaic Cells (2008)

Vertically aligned Mg-doped GaN nanorods have been epitaxially grown on n-type Si substrate to form a heterostructure for fabricating p-n heterojunction photovoltaic cells. The p-type GaN nanorod/n-Si heterojunction cell shows a well-defined rectifying behavior with a rectification ratio larger than 10(4) in dark. The cell has a high short-circuit photocurrent density of 7.6 mAlcm2 and energy conversion efficiency of 2.73% under AM 1.5G illumination at 100 mW/cm2. Moreover, the nanorod array may be used as an antireflection coating for solar cell applications to effectively reduce light loss due to reflection. This study provides an experimental demonstration for integrating one-dimensional nanostructure arrays with the substrate to directly fabricate heterojunction photovoltaic cells.
Mechanics-Based Solutions to RF MEMS Switch Stiction Problem (2004)

RF micro-electro-mechanical systems (MEMS) switches are an attractive solution to switch antenna bands and transmit/receive switching for future multiband, high bandwidth cell phones. However, Stiction is a major concern for resistive switches with metal-to-metal contact. An iterative-coupled electrostatic-structural analysis is utilized to evaluate the effect of design parameters on restoring force of MEMS switches. Parameters including metal thickness, dielectric thickness, beam-to-ground gap height, metal and dielectric width, and cantilever beam length can be evaluated. The electrostatic force is first calculated based on the electrical field component. A structural analysis is then performed to determine the cantilever beam deflection due to the electrostatic force. A unique integrated empirical-numerical method is used to quantitatively determine the stiction force based on measured actuation voltages for real devices. The analysis can provide quick evaluation and screenings of proposed designs to determine if their actuation voltage falls in the acceptable range. Simulation prediction agrees very well with test measurements. Although increasing cantilever thickness and shortening cantilever length both increase restoring force, the actuation voltage will increase significantly as a result. The most favorable modification is to increase the electrode area. A short and wide structure with a large area can increase restoring force while maintaining low actuation voltage. Compared to similar bi-layer designs, sandwich designs can be actuated at further reduced voltages without changing the beam restoring force. In addition, the sandwich structure, being thermal-stress-balanced, is less sensitive to temperature excursion. With the properly selected design parameters, the new designs will be able to achieve the break away restoring force of the original design at much lower actuation voltages. Switches with good electrical as well as mechanical performances have been successfully fabricated.
Gate driving of high power IGBT through a Double Galvanic Insulation Transformer (2006)

The reliability of the transmission of the switching signal of IGBT in a static converter is crucial. In fact, if the switching signals are badly transmitted, the power converter can be short-circuited with dramatic consequences. Thus, the operating of such a system can be stopped with heavy economic consequences, as it is the case for an electric train. Many techniques have been developed to achieve solutions for a safe transmission of switching signals with a good galvanic insulation. In very high-voltage, over 10 kV, an optimal solution is to use optic fibres. This technology is limited by the fibre degradation in high temperature atmosphere. Actually, this problem exists in trains. The common use of the radio frequency transmission (RFT) can be exploited to achieve an original IGBT wireless driver. This solution seems to be interesting because high temperature do not interfere with radio frequency transmission. However, radiated electromagnetic interferences (EMI) are drastically important in such an electrical environment, EMI can disturb the RFT. In order to optimise the transmission of switching signals, we have decided to transmit the signals through the energy supplying link. This last device is constituted by a double galvanic insulation transformer (DGIT). The difficulty is to transmit the energy, which is used for the IGBT driver supply and the switching signals in the same loop wire. The paper will highlight this aspect
Comparative observations on some bionomics of Japanese ixodid ticks under laboratory cultural conditions. (1976)

Seventeen species of Japanese ixodid ticks of the genera Amblyomma, Boophilus, Haemaphysalis, Ixodes, and Rhipicephalus were reared in the laboratory under almost the same cultural conditions. Their major biological characters, such as feeding, molting, oviposition, and hatching, were summarized in tables. There were some differences in these bionomics among the species. The general characteristics common to all the ticks, except Amblyomma testudinarium, were as follows. The feeding period in immature stages and adult females was 3 approximately 5 and 7 approximately 14 days, respectively. The engorged body weight in larvae, numphs, and females was 0.3 approximately 0.5, 3.5 approximately 5.0, and 100 approximately 300 mg, respectively. The potential sexuality could be estimated from the nymphal engorged weight in five species. The larval and nymphal molting periods at 25 degrees C were alike, or 10 approximately 20 days, and there were no significant sexual differences in nymphal molting period among six species. The body weight just after molting in nymphs, males, and females was 0.25 approximately 0.3, 1 approximately 2, and 2 approximately 3 mg, respectively. The pre-oviposition, oviposition, and egg-incubation periods at 25 degrees C were 4 approximately 10 days, 2 approximately 3 weeks, and 1 month, respectively.
Myocardial bridging (2005)

Myocardial bridging, a congenital coronary anomaly, is a clinical condition with several possible manifestations, and its clinical relevance is debated. This article reviews current knowledge about the anatomy, pathophysiology, clinical relevance, and treatment of myocardial bridging. Myocardial bridging is present when a segment of a major epicardial coronary artery, the 'tunnelled artery', runs intramurally through the myocardium. With each systole, the coronary artery is compressed. Myocardial bridging has been associated with angina, arrhythmia, depressed left ventricular function, myocardial stunning, early death after cardiac transplantation, and sudden death. Evidence indicates that the intima beneath the bridge is protected from atherosclerosis, and the proximal segment is more susceptible to development of atherosclerotic lesions because of haemodynamic disturbances. New techniques (e.g. intravascular ultrasonography and intracoronary Doppler studies) have revealed new characteristics and pathophysiologic processes such as diastolic flow abnormalities. Medical treatment generally includes beta-blockers. Nitrates should be avoided because symptoms may worsen. Intracoronary stents and surgery have been attempted in selected patients. Additional research is needed to define patients in whom myocardial bridging is potentially pathologic, and randomized multicentre long-term follow-up studies are needed to assess the natural history, patient selection, and therapeutic approaches.
Neuromorphic Analogue VLSI (1995)

Neuromorphic systems emulate the organization and function of nervous systems. They are usually composed of analogue electronic circuits that are fabricated in the complementary metal-oxide-semiconductor (CMOS) medium using very large-scale integration (VLSI) technology. However, these neuromorphic systems are not another kind of digital computer in which abstract neural networks are simulated symbolically in terms of their mathematical behavior. Instead, they directly embody, in the physics of their CMOS circuits, analogues of the physical processes that underlie the computations of neural systems. The significance of neuromorphic systems is that they offer a method of exploring neural computation in a medium whose physical behavior is analogous to that of biological nervous systems and that operates in real time irrespective of size. The implications of this approach are both scientific and practical. The study of neuromorphic systems provides a bridge between levels of understanding. For example, it provides a link between the physical processes of neurons and their computational significance. In addition, the synthesis of neuromorphic systems transposes our knowledge of neuroscience into practical devices that can interact directly with the real world in the same way that biological nervous systems do.
Initial stability of a modular uncemented, porous-coated femoral stem: a mechanical study. (1996)

A versatile modular hip system was used to evaluate the initial stability of a cementless femoral stem in anatomically consistent composite bones. Four implant bone configurations of varying proximal and distal fit/fill were tested. The implanted femurs were tested on an Instron 1331 materials testing machine in neutral loading and flexion loading; both translational micromotions and rotations of the implant relative to the bone were recorded on all three axes of motion, accounting for all 6 degrees of freedom of joint motion. Implants were then sectioned, and both endosteal canal fit and intramedullary canal fill were measured. Results indicate that (1) loading the implant in flexion by out-of-plane forces significantly increases both relative translation and rotation at the interface, (2) increasing the proximal fit reduces implant rotation about its longitudinal axis in flexion loading and (3) increasing the distal canal fit and fill increases prosthesis rotation about its longitudinal axis in flexion loading. These results indicate that the femoral stem is more unstable in out-of-plane loading, such as during stair climbing, and that increasing the proximal fit may enhance the initial rotational stability of an uncemented femoral stem.
Thermal Heterogeneity Within Human Atherosclerotic Coronary Arteries Detected In Vivo (1999)

Thermal heterogeneity within human atherosclerotic coronary arteries was shown in vivo by use of a special thermography catheter. This heterogeneity is larger in UA and AMI, suggesting that it may be related to the pathogenesis.
Regulation of the peptidylglutamyl-peptide hydrolyzing activity of the pituitary multicatalytic proteinase complex (1991)

The finding that the activity of the multicatalytic proteinase complex (MPC) is greatly activated by low concentrations of sodium dodecyl sulfate (SDS) and fatty acids led to the proposal that the proteolytic activity of the complex is latent and that activation is needed for expression of full activity. Kinetic examination of the nature of the latency with Cbz-Leu-Leu-Glu-2-naphthylamide, a substrate cleaved by the peptidylglutamyl-peptide hydrolyzing activity (PGPH activity) of the complex, showed that plots of velocity versus substrate concentration yield sigmoidal curves, implying the presence of two or more substrate binding sites and the presence of cooperative interactions between the sites. Hill plots of log [v/(Vmax-v)] versus log [S] gave slopes with a Hill coefficient of 2.2-2.4, suggesting that more than two subunits are expressing the PGPH activity. At saturating substrate concentrations, SDS and lauric acid exposed a masked component of PGPH activity that was about equal in magnitude to the overt activity measured in the absence of these detergents, showing that under the latter conditions only about half of the enzyme activity is expressed. Activation by SDS and lauric acid was greater at low than at high substrate concentrations and was associated with a shift of the substrate concentration at half-Vmax (apparent Km) toward lower values. The decrease in the apparent Km in the presence of SDS (but not in the presence of lauric acid) was associated with a decrease in cooperativity. The presence of at least two distinct PGPH activity components with different reactivities was also indicated by the finding of two distinct inactivation rate constants in reactions with 3,4-dichloroisocoumarin, an irreversible inhibitor of the enzyme.(ABSTRACT TRUNCATED AT 250 WORDS)
The InterMed Approach to Sharable Computer-interpretable Guidelines: A Review (2003)

InterMed is a collaboration among research groups from Stanford, Harvard, and Columbia Universities. The primary goal of InterMed has been to develop a sharable language that could serve as a standard for modeling computer-interpretable guidelines (CIGs). This language, called GuideLine Interchange Format (GLIF), has been developed in a collaborative manner and in an open process that has welcomed input from the larger community. The goals and experiences of the InterMed project and lessons that the authors have learned may contribute to the work of other researchers who are developing medical knowledge-based tools. The lessons described include (1) a work process for multi-institutional research and development that considers different viewpoints, (2) an evolutionary lifecycle process for developing medical knowledge representation formats, (3) the role of cognitive methodology to evaluate and assist in the evolutionary development process, (4) development of an architecture and (5) design principles for sharable medical knowledge representation formats, and (6) a process for standardization of a CIG modeling language.
Gene transfer mediated by alpha2-macroglobulin (1996)

alpha2-Macroglobulin covalently linked to poly(L)-lysine can be used as a vehicle for receptor-mediated gene transfer. This modified alpha2-macroglobulin maintains its ability to bind to the alpha2-macroglobulin receptor, and was shown to introduce a luciferase reporter gene plasmid into HepG2 human hepatoma cells in vitro. The alpha2-macroglobulin receptor is a very large and multifunctional cell surface receptor, whose rapid and efficient internalization rate makes it attractive for gene therapy, e.g. for hepatic gene targeting via injection into the portal vein.
The Glucocorticoid Receptor and RU 486 in Man (1995)

RU 486 is a prototype glucocorticoid antagonist with strong antiglucocorticoid activity in vitro and in vivo. Studies of its molecular mechanism of action have provided invaluable insights in the complex activation cascade of the GR itself. RU 486 effectively antagonizes glucocorticoids in most glucocorticoid-sensitive systems. Agonist effects, however, have been observed in some in vitro and in vivo systems, but remain the exception. In humans, administration of RU 486 causes generalized glucocorticoid resistance with high levels of cortisol compensating for the peripheral receptor blockade. This state is similar to that of patients with generalized familial glucocorticoid resistance. Because of its HPA axis stimulatory effects, RU 486 has limited chronic utility as an antiglucocorticoid. To date, the application of RU 486 can only be recommended in inoperable patients with ectopic ACTH secretion or adrenal carcinoma who have failed to respond to other treatments. The unusually long half-life of this drug also poses problems with titrating its dose within a therapeutic range. The development of a short-acting, selective glucocorticoid antagonist is therefore, a desirable goal of future research.