gebhart/patrepeval huggingface dataset:
Incrased Expression of Dopamine Transporter in Parkinson's Disease Mice Substantia Nigra by Electroacupuncture Therapy (2006)

Objective:To determine whether electroacupuncture(EA) treatment can regulate the expression of dopamine transporter(DAT) in Parkinson's disease(PD) mice substantia nigra compacta(SNC).Methods: Twenty-four male mice(C_(57)BL/6J) were averagely and randomly divided into controlled group,controlled+EA group,model group and EA group.PD model mice were induced by i.p.1-methyl,4-phenyl-1,2,3,6 tetrahydropyridine.We take EA treatment with frequency from 2 to 100HZ,volt arrange from 2 to 4V,points on Hegu(LI4) and Taichong(LV3).The treatment was once daily.After 21 times treatments,we killed all mice and detected the expression of DAT by immunohistochemistry.Results:Compared to model group(2.33±3.22),the DAT positive cells are more in EA group(24.67±13.01) with significant statistical differences(P0.01).Conclusion:EA can increase the expression of DAT in PD mice SNC.
Efficacy of Aqueous and Alcohol‐Based Quaternary Ammonium Sanitizers for Reducing  <i>Salmonella</i>  in Dusts Generated in Almond Hulling and Shelling Facilities (2009)

Recent large-scale outbreaks of salmonellosis with low-moisture foods have increased concerns regarding their safety. Little research or guidance is available on appropriate cleaning and sanitation programs for these food types. This research is focused on an evaluation of sanitation options for low-moisture foods, in particular almonds. The information should be applicable and useful to the nut industry and to other low-moisture foods.
La sal de la vida o el beso de la muerte (2002)

Pure rotational spectra of the ground electronic states of lead monoiodide and tin monoiodide have been measured using a chirped pulsed Fourier transform microwave spectrometer over the 7-18.5 GHz region for the first time. Each of PbI and SnI has a X (2)Π1/2 ground electronic state and may have a hyperfine structure that aids the determination of the electron electric dipole moment. For each species, pure rotational transitions of a number of different isotopologues and their excited vibrational states have been assigned and fitted. A multi-isotopologue Dunham-type analysis was carried out on both species producing values for Y01, Y02, Y11, and Y21, along with Λ-doubling constants, magnetic hyperfine constants and nuclear quadrupole coupling constants. The Born-Oppenheimer breakdown parameters for Pb have been evaluated and the parameter rationalized in terms of finite nuclear field effects. Analysis of the bond lengths and hyperfine interaction indicates that the bonding in both PbI and SnI is ionic in nature. Equilibrium bond lengths have been evaluated for both species.
How subsequent pregnancy affects outcome in women with a prior breast cancer. (1991)

Of all women who develop breast cancer, approximately 25% will do so in their premenopausal years and may still wish to bear children. The effect of a subsequent pregnancy, with its profound hormonal changes, on the outcome of the breast cancer (which itself may be hormonally responsive) is an important question. The prognosis of the original tumor also may influence the decision regarding pregnancy. Many studies have addressed these issues and have concluded that a pregnancy after a successfully treated breast cancer does not alter the outcome of that tumor, whether analyzed according to overall survival for all breast cancer patients or according to stage or axillary lymph node status. Nevertheless, it is recommended that pregnancy be delayed until 2 to 3 years after completion of treatment, especially if axillary nodes were positive for tumor--not because of any influence of the pregnancy on the malignancy, but rather to defer childbearing until after the period of greatest risk of recurrence of the tumor.
BASILIXIMAB [SIMULECT®] DRAMATICALLY REDUCES ACUTE REJECTION AFTER PEDIATRIC KIDNEY TRANSPLANTATION. (2000)

Cohn, Richard A.1; Sherbotie, Joseph R.2; Grimm, Paul C.3; Leone, John4; Taylor, Rodney4; Somerville, Troy2; Lemire, Jacques3 Author Information
Pooled Contextualized Embeddings for Named Entity Recognition (2019)

Alan Akbik, Tanja Bergmann, Roland Vollgraf. Proceedings of the 2019 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 1 (Long and Short Papers). 2019.
Driver Attitudes and Behaviors at Intersections and Potential Effectiveness of Engineering Countermeasures (2005)

This report describes the results of a focus group study that explored driver attitudes and behaviors at intersections to assess the likely impacts of new or existing infrastructure-based technologies/countermeasures.The focus group study is part of a larger research project that will provide the Federal Highway Administration (FHWA) with information about roadway user attitudes and behaviors at intersections.Specifically, the information concerns driving performance, perceptual and cognitive bottlenecks, constraints that can negatively impact intersection safety, and engineering or educational countermeasures for intersection safety with the greatest likely impact on performance and safety.
Progressive decrease of true intestinal calcium absorption with age in normal man. (1973)

The true intestinal absorption coefficient of calcium (a-value) was determined in 26 men and 26 women, normal in respect to calcium metabolism and intestinal function, by a double-isotope ratio technique. The age of the patients ranged from 12 to 81 years, and the a-values were between 20 and 75% of oral dose with a geometric mean of 34%. A highly significant negative linear correlation was present between the logarithm of a-value and age (r = −0.526, p
Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3 (2006)

Hdm2 and HdmX coordinately regulate the stability and function of p53. Each is overexpressed in subsets of many different types of malignancy, and most of these subsets maintain wild-type p53. Nutlins, newly discovered small-molecule inhibitors of the Hdm2-p53 interaction, offer a novel strategy for therapy of tumors with wild-type p53. We now show that Nutlin-3 efficiently induces apoptosis and diminishes long-term survival of human fibroblasts transformed in vitro by Hdm2 but not HdmX. The resistance of cells overexpressing HdmX to Nutlin-3 is due to its inability to disrupt the p53-HdmX interaction, resulting in continued suppression of p53 activity. Although HdmX overexpression yielded cells resistant to Nutlin-3, ablation of HdmX expression by short hairpin RNA sensitized tumor cells to Nutlin-3-mediated cell death or arrest. Furthermore, deletion of the COOH-terminal RING finger domain of HdmX completely reversed the resistance to Nutlin-3, probably reflecting the requirement of the RING finger for interaction with Hdm2. Thus, the relative abundance of Hdm2 and HdmX and the specificity of Nutlin-3 for Hdm2 influence the sensitivity of cells to p53-dependent apoptosis or arrest in response to Nutlin-3. Our findings establish Hdm2 and HdmX as independent therapeutic targets with respect to reactivating wild-type p53 as a means for cancer therapy.
CARBONATES AND OTHER SALTS IN THE ATACAMA DESERT AND ON MARS, AND THE IMPLICATIONS FOR THE ROLE OF LIFE IN CARBONATE FORMATION (2015)

The scarcity of carbonate on Mars has been difficult to reconcile with the morphologic evidence for a wet epoch in Martian history, and has weakened early interpretations of a water-rich Noachian. Limited soil carbonate from pre-Silurian Earth has created a similar conundrum, and in both instances this paradox has likely led to overreaching interpretations about past climates. To better understand the formation of carbonate on Mars, early Earth, and in present day hyperarid climates, we examined the distribution of carbonate in the Atacama Desert—a region that spans multiple climate regimes and allows us to isolate the effects of precipitation and plant cover on soil mineralogy. To better quantify the influences of vegetation on carbonate we utilized a simple one-dimensional precipitation model and simulated carbonate formation with or without plant cover under a range of relevant climatic conditions and soil morphologies. In the Atacama we found two distinct zones with only trace (<5%) carbonate: the "absolute desert" with precipitation too low to sustain plant life, and the high Andes where precipitation was significantly higher, but where the low mean annual temperature (MAT) inhibits plants. The fog-supported, low-elevation coastal "lomas" below approximately 800 meters above sea level (masl) and the higher elevations between approximately 2500-4500 masl are variably vegetated and contain abundant carbonate within the soils. Plants increase total evapotranspiration and its distribution with depth, weathering rates, and total pCO₂. Our model results show that all of these factors increase the formation of pedogenic soil carbonate. Without the influence of vegetation the diminished carbonate that is produced is flushed through the shallow soil, where it eventually precipitates in the deep vadose zone or is entrained by groundwater.
Multiparametric Duplex Real-Time Nucleic Acid Sequence-Based Amplification Assay for mRNA Profiling (2004)

Nucleic acid sequence-based amplification (NASBA) is a sensitive isothermal transcription-based amplification method. We have developed real-time NASBA assays to detect mRNA coding for the estrogen receptor alpha (ESR1) and the progesterone receptor (PGR) in breast tumors by means of duplex reactions using cyclophilin B (PPIB) as the normalizing gene. Both the ESR1/PPIB and PGR/PPIB duplex NASBA assays are highly sensitive, specific, and reproducible. Quantification is determined using external standard calibration curves and the ratio between the number of target and housekeeping gene mRNA copies. Amplification of the target gene in the duplex NASBA assay was disrupted when this latter was mixed with a large amount of the housekeeping PPIB gene, suggesting that it is preferable for the normalizing gene chosen to have an expression level comparable to the target gene. Sensitivity and robustness of the duplex NASBA assays were assessed in breast cancer cell lines. Such a rapid and easy-to-use multiparametric duplex real-time NASBA assay could also advantageously be set up for other mRNA profiling applications.
The Relationship between Homoserine and its Lactone (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Relationship between Homoserine and its LactoneMarvin D. ArmstrongCite this: J. Am. Chem. Soc. 1949, 71, 10, 3399–3402Publication Date (Print):October 1, 1949Publication History Published online1 May 2002Published inissue 1 October 1949https://pubs.acs.org/doi/10.1021/ja01178a037https://doi.org/10.1021/ja01178a037research-articleACS PublicationsRequest reuse permissionsArticle Views218Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vital DNA staining and cell sorting by flow microfluorometry (1980)

A procedure has been investigated for sorting viable cells according to their DNA content. Cells are stained with the U.V. activated fluorochromes 4'6-diamidino-2-phenylindole (DAPI), Hoechst 33258 or Hoechst 33342, and sorted with a Fluorescence Activated Cell Sorter. Hoechst 33342 is a suitable vital stain for a variety of cell types. Hoechst 33258 and DAPI, however, are quantitative vital stains for CHO cells only. Cloning efficiency is unaffected by the sorting procedure, and these stains are not mutagenic at concentrations suitable for vital staining. Potential applications of this procedure to cell biology are discussed.
Simple Wide Frequency Range Impedance Meter Based on AD5933 Integrated Circuit (2015)

Abstract As it contains elements of complete digital impedance meter, the AD5933 integrated circuit is an interesting solution for impedance measurements. However, its use for measurements in a wide range of impedances and frequencies requires an additional digital and analogue circuitry. This paper presents the design and performance of a simple impedance meter based on the AD5933 IC. Apart from the AD5933 IC it consists of a clock generator with a programmable prescaler, a novel DC offset canceller for the excitation signal based on peak detectors and a current to voltage converter with switchable conversion ratios. The authors proposed a simple method for choosing the measurement frequency to minimalize errors resulting from the spectral leakage and distortion caused by a lack of an anti-aliasing filter in the DDS generator. Additionally, a novel method for the AD5933 IC calibration was proposed. It consists in a mathematical compensation of the systematic error occurring in the argument of the value returned from the AD5933 IC as a result. The performance of the whole system is demonstrated in an exemplary measurement.
Conversation Clock: Visualizing audio patterns in co-located groups (2007)

Aural conversation is ephemeral by nature. The interaction history of conversation fades as the present moment demands the attention of participants. In this paper, we explore the nature of group interaction by augmenting aural conversation with a persistent visualization of audio input. This visualization, conversation clock, displays individual contribution via audio input and provides a corresponding social mirror over the course of interaction. This paper describes the implementation of conversation clock, provides observations on an initial pilot study, and outlines the future progression of this research
Highly efficient perovskite solar cells based on a nanostructured WO<sub>3</sub>–TiO<sub>2</sub>core–shell electron transporting material (2014)

A novel core–shell nanostructured WO<sub>3</sub>is investigated in detail and shown to work successfully as an electron transporting material in hybrid perovskite solar cells. A thin TiO<sub>2</sub>shell reduces charge recombination while highly textured single-crystal WO<sub>3</sub>nanostructures promote fast electron transport leading to an efficiency above 11%.
A closer look at keyboard acoustic emanations (2012)

We take a closer look at keyboard acoustic emanations specifically for the purpose of eavesdropping over random passwords. In this scenario, dictionary and HMM language models are not applicable; the attacker can only utilize the raw acoustic information which has been recorded. We investigate several existing signal processing techniques for our purpose, and introduce a novel technique -- time-frequency decoding -- that improves the detection accuracy compared to previous techniques. We also carefully examine the effect of typing style -- a crucial variable largely ignored by prior research -- on the detection accuracy. Our results show that using the same typing style (hunt and peck) for both training and decoding the data, the best case success rate for detecting correctly the typed key is 64% per character. The results also show that changing the typing style, to touch typing, during the decoding stage reduces the success rate, but using the time-frequency technique, we can still achieve a success rate of around 40% per character.
PCB Origami: A Material-Based Design Approach to Computer-Aided Foldable Electronic Devices (2013)

Origami is traditionally implemented in paper, which is a passive material. This research explores the use of material with embedded electronics such as printed circuit boards (PCB) as the medium for origami folding to create an interactive folding experience and to generate foldable objects with added functionalities. PCBs are produced as 2D shapes. By folding PCB arrays, it is possible to create 3D objects that contain electronic functions. Conductivity, output devices (such as light emitting diodes) and microcontroller computation can create an interactive folding experience, for user guidance and verification of the folding. We call this approach and methodology PCB origami. The work presented in this paper describes two unique interaction and fabrication techniques for creating and folding electronic materials. We demonstrate prototypes and present verification/evaluation strategies for guiding the user through the folding process.
A new approach to coupling/decoupling networks for EMC testing (1999)

Testing of immunity to EN61000-4-6 and of emission to EN55022 is achieved using Coupling and Decoupling networks (CDNs). The paper will describe several improvements to the configuration, construction and connection of such networks. Firstly it will be shown that embodying the whole of the 150Ω source impedance Within the CDN, together with built-in voltage measurement, substantially reduces the energising power required and so reduces system cost. At the same time this simplifies calibration. Secondly the factors limiting frequency response will be analysed, and it will be shown that With a carefully-designed CDN and a sufficiently small EUT it is certainly practicable to extend the maximum Injection frequency to 400MHz. Lastly it will be described how a limited set of CDNs can be adapted to meet a large variety of practical applications in telecommunications, computing, and process control by appropriate CDN intemal design and linking Within the CDN connectors. The improved versatility and wider frequency range are equally applicable to emission testing to EN55022.
Diet affects nutrient digestibility, hematology, and serum chemistry of senior and weanling dogs123 (2004)

The objective of this experiment was to determine the effects of age and diet on serum chemistry, hematology, and nutrient digestibility in healthy dogs. Twelve senior (11 yr old; six males and six females) and 12 weanling (age = 8 wk old; six males and six females) beagles were randomly assigned to one of two dietary treatments: 1) an animal product-based (APB) diet or 2) a plant product-based (PPB) diet. The APB diet was primarily composed of brewer's rice, chicken by-product meal, and poultry fat, whereas the primary ingredients of the PPB diet included corn, soybean meal, wheat middlings, and meat and bone meal. Dogs remained on experiment for 12 mo. A 4-d total fecal collection was performed to determine apparent macronutrient digestibilities after 3 and 10 mo. Blood samples were collected at baseline and after 3, 6, 9, and 12 mo on study. After 3 mo, dogs fed the APB diet had greater (P < 0.001) DM (6 percentage units) and OM (7 percentage units) digestibilities than dogs fed the PPB diet. Senior dogs had greater DM (2.5 percentage units; P = 0.07) and OM (3 percentage units; P < 0.01) digestibilities than young dogs. Dogs fed the PPB diet had a lower (P < 0.001) fecal DM percentage (7.5 percentage units) and greater (P < 0.001) fecal output (253 vs. 97 g/d, as-is basis). After 10 mo, age did not affect nutrient digestibility or fecal characteristics. However, the effect of diet after 10 mo was similar to that observed after 3 mo, as dogs fed the PPB diet had a lower (P < 0.001) fecal DM percentage (7 percentage units), lower OM (4 percentage units; P = 0.09) and fat (6 percentage units; P < 0.001) digestibilities, and greater (P < 0.005) fecal output (235 vs. 108 g/d, as-is basis). At baseline, most serum metabolites were different between age groups, with weanlings having several metabolite concentrations outside the reference ranges for adult dogs. Blood cholesterol, red blood cells, hemoglobin, hematocrit, creatinine, total protein, albumin, bilirubin, sodium, chloride, and alanine transaminase were present in greater (P < 0.05) concentrations in senior dogs, but weanling dogs had greater (P < 0.05) concentrations of glucose, platelets, Ca, P, K, and alkaline phosphatase. Over time, blood cholesterol concentrations were affected by age (P < 0.05) and diet (P < 0.01). Senior dogs had greater (P < 0.05) cholesterol concentrations than weanling dogs. Moreover, dogs fed the APB diet had greater (P < 0.05) cholesterol concentrations than dogs fed the PPB diet. Overall, although serum metabolite concentrations of weanlings were different from senior dogs at baseline, as weanlings matured into young adults, metabolite concentrations were similar to those of senior dogs. Diet had the largest effects on nutrient digestibilities and fecal characteristics. Canine age and diet must be considered when interpreting experimental and clinical data.
Influence of germanium on thermal dewetting and agglomeration of the silicon template layer in thin silicon-on-insulator (2009)

We investigate the influence of heteroepitaxially grown Ge on the thermal dewetting and agglomeration of the Si(0 0 1) template layer in ultrathin silicon-on-insulator (SOI). We show that increasing Ge coverage gradually destroys the long-range ordering of 3D nanocrystals along the ⟨1 3 0⟩ directions and the 3D nanocrystal shape anisotropy that are observed in the dewetting and agglomeration of pure SOI(0 0 1). The results are qualitatively explained by Ge-induced bond weakening and decreased surface energy anisotropy. Ge lowers the dewetting and agglomeration temperature to as low as 700 °C.
Structural features of the human C3 gene: Intron/exon organization, transcriptional start site, and promoter region sequence (1991)

The third component of human complement (C3) is a key molecule in the activation of the complement cascade. C3 cDNA fragments were used to identify seven cosmid clones that covered all but 1 kilobase pair (kb) of the C3 gene. The remainder of the gene was cloned by using the polymerase chain reaction. These clones were used to identify the intron/exon boundaries and to map the gene. The C3 gene is 42 kb in length and comprises 41 exons ranging in size from 52 to 213 base pairs (bp). The transcription start site was identified by primer extension, and approximately 1 kb of DNA upstream of this site was sequenced. Putative TATA and CAAT boxes were identified along with a number of regions that shared homology with known regulatory sequences. These include responsive elements for interferon-gamma, interleukin-6, nuclear factor kappa B, estrogen, glucocorticoids and thyroid hormone. Several of these agents have been shown to affect C3 synthesis and mRNA levels. The sizes of the exons in C3 were compared to those of C4 and alpha 2-macroglobulin (alpha 2M). Thirty-nine of 41 exons in C4 were found to be of similar size to the analogous ones in C3, and two-thirds of those in alpha 2M were also similarly sized, supporting the hypothesis that these genes arose from a common ancestor.