gebhart/patrepeval huggingface dataset:
Statistical Theory of Overlap for Variable Poisson Density: Relaxation of Constraint of Randomness (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStatistical Theory of Overlap for Variable Poisson Density: Relaxation of Constraint of RandomnessJoe M. DavisCite this: Anal. Chem. 1994, 66, 5, 735–746Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/ac00077a025https://doi.org/10.1021/ac00077a025research-articleACS PublicationsRequest reuse permissionsArticle Views71Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
FPGA-Based Platform Development for Change Detection in GTAW Welding Process (2010)

This paper presents the development of an FPGA-based platform for on-line discontinuity detection in a Gas Tungsten Arc Welding (GTAW) process, through the monitoring its voltaic arc, using an optical infrared sensor. The FPGA-based platform uses a hardware/software co-design approach, in which the hardware part includes a change detection peripheral, apart from general purpose peripherals (e.g. UART, timer) and several customized ones such as memory for storing discontinuity data and an ADC driver. The change detection peripheral comprises the filtering stage and the stopping rule stage, which include a Kalman filter and a cumulative sum (CUSUM) modules, respectively. In order to validate the FPGA-based platform, several experimental tests in the field have been made by introducing intentional discontinuities in the weld bead. These experimental results have shown a suitable performance of the overall system in the on-line discontinuity detection task. In this paper the change detection peripheral is described as well as the synthesis results related to performance and resources consumption. In the overall co-design approach, the software part includes a Micro Blaze soft-processor to control and managing the overall platform, including the interface issues.
<i>Ab initio</i> design of coherent thermal sources (2007)

Emission of thermal light from a hot body has been considered for a long time as broadband and quasi-isotropic. Today, we know that this paradigm is wrong and it has been shown that many micro- and nanostructured materials are able to radiate in narrow spectral bands and around specific directions of space. However, so far, only heuristic strategies based on trial and error have been followed for engineering such sources. Here, we present a general method for the ab initio design of coherent thermal sources by using only the first principles of optics. Our results pave the way toward the inverse design of new composite emitting structures for high performance applications in optics.
UNAFold (2008)

The UNAFold software package is an integrated collection of programs that simulate folding, hybridization, and melting pathways for one or two single-stranded nucleic acid sequences. The name is derived from “Unified Nucleic Acid Folding.” Folding (secondary structure) prediction for single-stranded RNA or DNA combines free energy minimization, partition function calculations and stochastic sampling. For melting simulations, the package computes entire melting profiles, not just melting temperatures. UV absorbance at 260 nm, heat capacity change (Cp), and mole fractions of different molecular species are computed as a function of temperature. The package installs and runs on all Unix and Linux platforms that we have looked at, including Mac OS X. Images of secondary structures, hybridizations, and dot plots may be computed using common formats. Similarly, a variety of melting profile plots is created when appropriate. These latter plots include experimental results if they are provided. The package is “command line” driven. Underlying compiled programs may be used individually, or in special combinations through the use of a variety of Perl scripts. Users are encouraged to create their own scripts to supplement what comes with the package. This evolving software is available for download at http://www.bioinfo.rpi.edu/applications/hybrid/download.php .
Structuring as a Basis for Product Modelling (1999)

decomposition Structure means the way which things are built up. A composite product does not exhibit one structure, but hides in its structure of parts several different structuring principles, which fit the production, service, transport etc. Structuring of product models is complex where many factors are influencing. This paper identifies four factors that are influencing the structure of a product model: genetics, functionality/property, product life and product assortment. Three principles, which support determination of product model structures, are proposed. 1
Modeling Langmuir probes in multi-component plasmas (2008)

Langmuir probes are conceptually simple devices and have long been the primary diagnostic for plasmas, but interpreting the output is rarely straightforward, even in plasmas consisting of Maxwellian electrons and a single ion species. The problem is worse yet in more complicated plasmas where theoretical calculations are lacking. To help interpret probe data, this work presents a numerical scheme capable of modeling spherical and cylindrical probes in plasmas containing any number of charged species, positive or negative. The scheme is based on solving the derivative of Poisson's equation as an initial-value problem rather than solving Poisson's equation as a boundary-value problem. Because the new equation is linear in the electric field, stable solutions are possible. The same approach can be used with other nonlinear ordinary differential equations as well, but in most cases the initial conditions must be adjusted until the original boundary conditions are satisfied. Fortunately, this difficulty is easily circumvented for certain types of problems, including Langmuir probes. Accordingly, Langmuir probes can be modeled quickly and easily, even in plasmas containing multiple ion species and multi-temperature electrons. Examples are given for electropositive plasmas, electronegative plasmas, and two-temperature electrons.
Sickle Cell Disease (2013)

Get immediate, on-the-spot help for safe, effective, confident inpatient care! Developed by top pediatric hospitals, the all-new Caring for the Hospitalized Child: A Handbook of Inpatient Pediatrics is sure to become your go-to resource from initial evaluation through hospital discharge management.Pediatric hospitalists with extensive hands-on experience offer proven recommendations for dozens of pediatric inpatient problems. Here's what you need to know - and what you need to do - for anaphylaxis; cardiac conditions; dermatological; ENT and GI issues; infectious diseases; seizure; eye trauma; fractures; physical and sexual abuse; and much more.
Poly(ADP-ribose) Glycohydrolase Deficiency Sensitizes Mouse ES Cells to DNA Damaging Agents (2009)

Poly(ADP-ribose) glycohydrolase (Parg) is the main enzyme for degradation of poly(ADP-ribose) by splitting ribose-ribose bonds. Parg-deficient (Parg(+/-) and Parg(-/-)) mouse ES cell lines have been established by disrupting both alleles of Parg exon 1 through gene-targeting. A transcript encoding a full length isoform of Parg was eliminated and only low amounts of Parg isoforms were detected in Parg(-/-) embryonic stem (ES) cells. Poly(ADP-ribose) degradation activity was decreased to one-tenth of that in Parg(+/+) ES cells. Parg(-/-) ES cells exhibited the same growth rate as Parg(+/+) ES cells in culture. Sensitivity of Parg(-/-) ES cells to various DNA damaging agents, including an alkylating agent dimethyl sulfate, cisplatin, gemcitabine, 5-fluorouracil, camptothecin, and gamma-irradiation was examined by clonogenic survival assay. Parg(-/-) ES cells showed enhanced lethality after treatment with dimethyl sulfate, cisplatin and gamma-irradiation compared with wild-type (Parg(+/+)) ES cells (p<0.05, respectively). In contrast, a sensitization effect by Parg-deficiency was not observed with gemcitabine and camptothecin. These results suggest the possibility that functional inhibition of Parg leads to sensitization of tumor cells to some chemo- and radiation therapies.
Son1p is a component of the 26S proteasome of the yeast <i>Saccharomyces cerevisiae</i> (1998)

A son1 mutant was isolated as a mutant showing synthetic lethality with nin1-1 which is defective in the p31 component of the regulatory subunit of the yeast 26S proteasome. son1delta showed a synthetic effect with sen3delta and sun1delta, both components of the 26S proteasome, and with cdc28-1N. The 26S proteasome was partially purified from the wild type yeast. The FPLC fractions were analyzed by Western blotting using anti-Son1p antibody and antibodies against some authentic subunits of the 26S proteasome, and we found that Son1p co-migrated with components of the 26S proteasome. The 26S proteasome containing fraction was immunoprecipitated with anti-Son1p antibody. The resultant precipitate contained Nin1p, Sun1p, TBP1, and the 20S proteasome. Combining genetic and biochemical results together, we concluded that Son1p is a component of the yeast 26S proteasome.
Small‐Molecule Targeting of the Mitochondrial Compartment with an Endogenously Cleaved Reversible Tag (2009)

Targeted accumulation of chemically unaltered compounds within the mitochondrial compartment has not yet been achieved. Here we describe a reversible tag that is endogenously cleaved after mitochondrial accumulation has occurred. Specifically, we have reversibly tagged alpha-lipoic acid with a triphenylphosphonium moiety that is cleaved by the physiologically contained mitochondrial aldehyde dehydrogenase (ALDH-2). This reversibly tagged compound activates the lipoic acid-sensitive pyruvate dehydrogenase complex, and this results in increased glucose oxidation. We observed a reduction in ROS accumulation after preincubation with the reversibly tagged compound, whereas untagged or irreversibly tagged compounds either had no effect on ROS formation or rather caused increased oxidative stress, respectively. Lastly, the cytotoxicity of the reversibly tagged compound is less than that of the irreversibly tagged compound. Overall, reversible tagging combines decreased tag-related cytotoxicity with increased bioactivity, and this potentially provides a novel concept in mitochondrial pharmacology.
[Teratogenic effect of N-phthaloyl-L-aspartic acid on the mouse (author's transl)]. (1977)

The optical isomers of N-phthaloyl-aspartic acid, structurally related to thalidomide, were administered i.p. to pregnant mice on day 9 of gestation; the injected solutions contained Tween 20 as solubilizer. N-Phthaloyl-L-aspartic acid exerts an embryotoxic and teratogenic effect as is evident by the high incidence of resorption and malformations. On the other hand the D-isomer is devoid of any embryotoxic and teratogenic activity under the same conditions of experiment.
Quantum Hall Effect in a Graphene p-n Junction (2007)

We report on the fabrication and transport studies of a single-layer graphene p-n junction. Carrier type and density in two adjacent regions are individually controlled by electrostatic gating using a local top gate and a global back gate. A functionalized Al203 oxide that adheres to graphene and does not significantly affect its electronic properties is described. Measurements in the quantum Hall regime reveal new plateaus of two-terminal conductance across the junction at 1 and 3/2 times the quantum of conductance, e2/h, consistent with theory.
Foundations of C++ and object-oriented programming (1995)

From the Publisher:
Foundations of C++ and Object-Oriented Programming is the complete C++ tutorial and reference you need to master the C++ language and gain an in-depth understanding of object-oriented programming. With programming guru Namir Clement Shammas to guide you, you'll learn to build high-performance C++ applications for any operating system, including Windows 95. You'll also find out how to exploit the new Standard Template Library to optimize your development efforts. Plus, the bonus CD-ROM accompanying Foundations of C++ and Object-Oriented Programming features a fully-searchable hypertext version of the book, the complete Hewlett-Packard STL, and valuable source code.
Tunneling Characteristics of Au–Alkanedithiol–Au Junctions formed via Nanotransfer Printing (nTP) (2012)

Construction of permanent metal-molecule-metal (MMM) junctions, though technically challenging, is desirable for both fundamental investigations and applications of molecule-based electronics. In this study, we employed the nanotransfer printing (nTP) technique using perfluoropolyether (PFPE) stamps to print Au thin films onto self-assembled monolayers (SAMs) of alkanedithiol formed on Au thin films. We show that the resulting MMM junctions form permanent and symmetrical tunnel junctions, without the need for an additional protection layer between the top metal electrode and the molecular layer. This type of junction makes it possible for direct investigations into the electrical properties of the molecules and the metal-molecule interfaces. Dependence of transport properties on the length of the alkane molecules and the area of the printed Au electrodes has been examined systematically. From the analysis of the current-voltage (I-V) curves using the Simmons model, the height of tunneling barrier associated with the molecule (alkane) has been determined to be 3.5 ± 0.2 eV, while the analysis yielded an upper bound of 2.4 eV for the counterpart at the interface (thiol). The former is consistent with the theoretical value of ~3.5-5.0 eV. The measured I-V curves show scaling with respect to the printed Au electrode area with lateral dimensions ranging from 80 nm to 7 μm. These results demonstrate that PFPE-assisted nTP is a promising technique for producing potentially scalable and permanent MMM junctions. They also demonstrate that MMM structures (produced by the unique PFPE-assisted nTP) constitute a reliable test bed for exploring molecule-based electronics.
Wireless systems and interference avoidance (2002)

Motivated by the emergence of programmable radios, we seek to understand a new class of communication system where pairs of transmitters and receivers can adapt their modulation/demodulation method in the presence of interference to achieve better performance. Using signal to interference ratio as a metric and a general signal space approach, we present a class of iterative distributed algorithms for synchronous systems which results in an ensemble of optimal waveforms for multiple users connected to a common receiver (or colocated independent receivers). That is, the waveform ensemble meets the Welch (1974) bound with equality and, therefore, achieves minimum average interference over the ensemble of signature waveforms. We derive fixed points for a number of scenarios, provide examples, look at ensemble stability under user addition and deletion as well as provide a simplistic comparison to synchronous code-division multiple-access. We close with suggestions for future work.
Mechanisms of Poly-N-Acetyl Glucosamine Polymer–Mediated Hemostasis: Platelet Interactions (2004)

Poly-N-acetyl glucosamine fiber material promotes hemostasis by the activation of platelets.
Global intensity correction in dynamic scenes (2007)

Changing image intensities causes problems for many computer vision applications operating in unconstrained environments. We propose generally applicable algorithms to correct for global differences in intensity between images recorded with a static or slowly moving camera, regardless of the cause of intensity variation. The proposed intensity correction is based on intensity-quotient estimation. Various intensity estimation methods are compared. Usability is evaluated with background classification as example application. For this application we introduced the PIPE error measure evaluating performance and robustness to parameter setting. Our approach retains local intensity information, is always operational and can cope with fast changes in intensity. We show that for intensity estimation, outlier removal is essential for dynamic scenes. For image sequences with changing intensity, the best performing algorithm (MofQ) improves foregroundbackground classification results up to a factor two to four on real data.
CAPEX Costs of Lightly Loaded Restorable Networks under a Consistent WDM Layer Cost Model (2009)

Shared protection promises the benefits of lower network capacity utilization without sacrificing the availability level of dedicated protection. Shared protection is often evaluated in terms of its spare capacity efficiency, but seldom in terms of real-world CAPEX (capital expenditure) costs. In this paper, we investigate the design of several shared protection architectures under a standardized cost model for the WDM layer, developed recently within the European NOBEL project. This paper presents a comparative study of the implementations and costs of these architectures under this model. Findings show a counterintuitive relationship between network capacity utilization and design cost when the network is lightly loaded.
Activation of Akt correlates with resistance to endocrine therapy for metastatic breast cancer (2005)

9500 Background: In breast cancer, the PI3K/Akt pathway can be activated by membrane receptors, including the HER family of growth factor receptors. Akt promotes breast cancer cell survival and it has been suggested that Akt promotes resistance to chemotherapy, trastuzumab, and tamoxifen. This suggests that targeting the PI3K/Akt pathway may increase the therapeutic efficacy of breast cancer therapy. Methods: 1. We analyzed the activation of Akt by immunohistochemical analyses of expression of phosphorylated Akt (pAkt) in breast cancer, from 253 patients who underwent surgery at our department. We also evaluated the expression of HER2, estrogen receptor (ER), and progesterone receptor (PR) by immunohistochemistry. 2. Thirty-five patients with metastatic breast cancer received 44 endocrine therapies. We evaluated the correlation of pAkt expression with effect of the endocrine therapy in those patients. Results: 1. Expression of pAkt was positive in 85 samples (33.6%). Expression of pAkt significantly correlated with overexpression of HER2 (p<0.0001) and inversely correlated with PR expression (p<0.05). There was no correlation between of ER expression and pAkt expression. 2. Endocrine therapies for recurrent cases were as follows; Aromatase inhibitor for 21 cases, LH-RH agonist for 7 cases, SERM for 15 cases and MPA for one case. We defined CR, PR, and SD as effective and PD as not effective. High expression of pAkt and HER2 in primary tumor well correlated with resistance of endocrine therapy (p=0.0045 and p=0.0229) (Table). Conclusion: Activation of Akt correlated with HER2 overexpression and inversely correlated with PR expression. Activation of Akt correlated with endocrine therapies for metastatic breast cancer. This study suggets that pAkt may be used as a predictor of resistance of endocrine therapy for breast cancer and that inhibition of Akt may increase the efficacy of endocrine therapy. No significant financial relationships to disclose.
A fully bio-based epoxy vitrimer: Self-healing, triple-shape memory and reprocessing triggered by dynamic covalent bond exchange (2019)

Vitrimers are a new type of polymers with promising applications in innovative materials. Epoxidized soybean oil (ESO) is an ideal candidate for vitrimer preparation owing to its abundant epoxy groups. However, preparing plant oil-based vitrimers with high glass transition temperatures (Tg) and strength remains challenging. A novel and fully bio-based vitrimer with a Tg above room temperature was synthesized from ESO and a rosin derivative-fumaropimaric acid (FPA) and exhibited excellent self-healing, shape memory, and reprocessing due to the presence of dynamic covalent bond exchange. The fully bio-based ESO-FPA vitrimer exhibited a Tg of 65 °C and a tensile strength of 16 MPa, which resulted from the rigid structure and tricarboxylic groups of FPA. The effect of transesterification reactions on the network structure was confirmed through stress relaxation. Our work expands the applications of commercial ESO in vitrimer materials and provides a novel approach to prepare bio-based vitrimers with desirable properties.
TRPC channels are necessary mediators of pathologic cardiac hypertrophy (2010)

Pathologic hypertrophy of the heart is regulated through membrane-bound receptors and intracellular signaling pathways that function, in part, by altering Ca(2+) handling and Ca(2+)-dependent signaling effectors. Transient receptor potential canonical (TRPC) channels are important mediators of Ca(2+)-dependent signal transduction that can sense stretch or activation of membrane-bound receptors. Here we generated cardiac-specific transgenic mice that express dominant-negative (dn) TRPC3, dnTRPC6, or dnTRPC4 toward blocking the activity of the TRPC3/6/7 or TRPC1/4/5 subfamily of channels in the heart. Remarkably, all three dn transgenic strategies attenuated the cardiac hypertrophic response following either neuroendocrine agonist infusion or pressure-overload stimulation. dnTRPC transgenic mice also were partially protected from loss of cardiac functional performance following long-term pressure-overload stimulation. Importantly, adult myocytes isolated from hypertrophic WT hearts showed a unique Ca(2+) influx activity under store-depleted conditions that was not observed in myocytes from hypertrophied dnTRPC3, dnTRPC6, or dnTRPC4 hearts. Moreover, dnTRPC4 inhibited the activity of the TRPC3/6/7 subfamily in the heart, suggesting that these two subfamilies function in coordinated complexes. Mechanistically, inhibition of TRPC channels in transgenic mice or in cultured neonatal myocytes significantly reduced activity in the calcineurin-nuclear factor of activated T cells (NFAT), a known Ca(2+)-dependent hypertrophy-inducing pathway. Thus, TRPC channels are necessary mediators of pathologic cardiac hypertrophy, in part through a calcineurin-NFAT signaling pathway.
Extracorporeal Immunoadsorption for the Treatment of Haemophilic Patients with Inhibitors to Factor VIII or IX (1999)

Immunoadsorption can be used in cases of acute bleeding, before surgery, acquired factor VIII (FVIII) antibodies, and before the start of immune tolerance therapy. We suggest the inclusion of this method in immune tolerance protocols in order to improve levels, recovery, and half-life of FVIII and to save concentrates.