gebhart/patrepeval huggingface dataset:
Procoagulant Soluble Tissue Factor Is Released From Endothelial Cells in Response to Inflammatory Cytokines (2005)

Inflammatory cytokines alter the hemostatic balance of endothelial cells (ECs). Alternatively spliced human tissue factor (asHTF), a soluble isoform of tissue factor (TF), has recently been detected in ECs, possibly contributing to procoagulability. Agonists regulating asHTF expression and release are yet unknown. This study examines the effect of TNF-alpha and IL-6 on the endothelial expression of both TF variants and delineates the impact of asHTF on the procoagulability of extracellular fluids. asHTF and TF mRNA were assessed by real-time PCR, and asHTF, TF, and tissue factor pathway inhibitor (TFPI) proteins by Western blot and fluorescence microscopy before and after stimulation with TNF-alpha (10 ng/mL) or IL-6 (10 ng/L). The procoagulability of cell supernatant was analyzed by a chromogenic assay with or without phospholipid vesicles. We found asHTF mRNA to be maximally increased 10 minutes after TNF-alpha and 40 minutes after IL-6 treatment (asHTF/GAPDH ratio 0.0223+/-0.0069 versus 0.0012+/-0.0006 for control, P<0.001 and 0.0022+/-0.0004 versus 0.0012+/-0.0007, P<0.05, respectively). Not only was asHTF increased, but also TFPI decreased after cytokine treatment. asHTF was found in the supernatant as early as 5 hours after TNF-alpha stimulation, supporting factor Xa generation after relipidation (6.55+/-1.13 U versus 2.99+/-0.59 U in control supernatant, P<0.00001). Removal of asHTF from supernatants by immunoprecipitation diminished its procoagulability to baseline. The soluble TF isoform expressed and released from ECs in response to inflammatory cytokines becomes procoagulant in the presence of phospholipids. Thus, asHTF released from ECs is a marker for and a contributor to imbalanced hemostasis.
Impact of synchronization on receiver performance in wideband CDMA networks (2002)

Synchronization may severely impact the capacity or spectrum efficiency of wideband CDMA networks. Evaluations of the uplink capacity for improved STAR and the 2D-RAKE with both perfect and active synchronization indicate that synchronization with the early-late gate component of a RAKE-type receiver may constitute a bottleneck for any performance improvement. Enhancement of synchronization remains a key issue. Results also suggest that STAR offers a promising alternative to the 2D-RAKE with early-late gate, offering on average an increase in spectrum efficiency of more than 100% in the presence of synchronization errors at both data rates of 9.6 and 144 kbps.
Phase 1 dose escalation trial of the safety and pharmacokinetics of cabozantinib concurrent with temozolomide and radiotherapy or temozolomide after radiotherapy in newly diagnosed patients with high‐grade gliomas (2015)

Cabozantinib at a dose of 40 mg daily with RT plus TMZ and post-RT TMZ for patients with newly diagnosed high-grade glioma was generally well tolerated, and demonstrated no pharmacokinetic interactions with concurrent TMZ. Given the strong theoretical rationale for combining anti-VEGF and anti-MET activity with standard therapy, cabozantinib at a dose of 40 mg daily warrants evaluation in combination with standard therapy for patients with newly diagnosed glioblastoma.
Mobile Platform as a Service A Case Study of User Friendly Approach to Mobile Strategy (2015)

Last few decades, opportunities for improvements in IT efficiency and performance through resource centralization and with mobility (service at anywhere and anytime) have increased very rapidly. This efficiency and performance gain can be achieved by providing the service oriented architecture in which shared computing and storage resources over a network in a self-service manner without human intervention. The paper includes the characteristics of mobile platform as a service (MPaaS) and its requirements to justify the necessity of such platforms. It also presents the potentials that it possesses through the case study of project "Mobile Seva" M-Governance initiative in India. Through the Mobile Seva Government Departments are enabled to offer the public services over mobile devices across various mobile-based delivery channels such as Short Message Services (SMS), Voice / Interactive Voice Response System (IVRS), Unstructured Supplementary Service Data (USSD), and mobile applications (m-Apps).
<i>Trypanosoma brucei</i>infection induces apoptosis and up-regulates neuroleukin expression in the cerebellum (2001)

Human infection with Trypanosoma brucei may result in meningo-encephalitis, neuronal demyelination, blood-brain-barrier dysfunction, peri-vascular infiltration, astrocytosis and neuronal apoptosis. Prevention of the short- or long-term, parasite-induced, neuronal assault requires a better understanding of the host's responses to the infection at the molecular level. Northern analysis, cDNA micro-arrays, reverse-transcrip-tase-PCR (RT-PCR), SDS-PAGE and immunohistology were therefore used to investigate global gene and protein expression in the brains of mice infected with T. brucei. Temporal and spatial expression of neuroleukin (NLK), a predominant neurotrophin which is associated with neuronal protection and regeneration during neuronal assault in the brain, was then assessed. Expression of 20 of the 588 genes investigated (representing pro- and anti-inflammatory immuno-modulators, growth factors, neurotransmitters, and pro- and anti-apoptosis factors) was significantly altered (P < 0.05). TUNEL analysis revealed extensive apoptosis at peak parasitaemia, mainly in the cerebellum. RT-PCR analysis of two regulators of apoptosis, Bcl-x(L) (anti-apoptotic) and Bax (pro-apoptotic), revealed equivalent increases in levels of expression. NLK expression was up-regulated in punctated fashion in brain and was mainly localized to abnormal (stellate) catecholamine neurons (CN) in the locus coeruleus (LC) of infected [and, to a lesser degree, the normal (polygonal) cells of uninfected] brainstem. Expression of NLK receptor (NLK-R) was inversely correlated with that of NLK. At peak parasitaemia, trypanosome infection apparently induces cerebellar apoptosis and a corresponding increase in NLK expression. NLK may be modulating inflammation and is probably involved in protecting CN and the cerebellum against apoptosis.
Measurement of apoptosis and proliferation of bone marrow plasma cells in patients with plasma cell proliferative disorders (1999)

The proliferative rate of malignant plasma cells, as measured by the plasma cell labelling index (PCLI), is an important prognostic factor in multiple myeloma (MM); however, the PCLI alone is probably Inadequate to describe tumour growth because it ignores the idea that myeloma cells may have a reduced rate of apoptosis. The aims of this study were to develop a flow cytometric method to measure the apoptosis index of fresh marrow plasma cells and develop a plasma cell growth index (PCGI) that related both proliferation and apoptosis to disease activity. Marrow aspirates were obtained from 91 patients with plasma cell disorders and the plasma cells in apoptosis were identified by either 7-amino actinomycin-D (7-AAD) or annexin V-FITC three-colour flow cytometry. The median plasma cell apoptotic index (PCAI) for patients with monoclonal gammopathy of undetermined significance (MGUS), smouldering or indolent myeloma (SMM/IMM), and new multiple myeloma (MM) was 5.2, 3.4 and 2.4, respectively (P=0.03, MGUS v MM). The median PCLI for these same patient groups was 0.0, 0.2 and 0.6, respectively (P<0.001, MGUS v MM). The paired PCLI and PCAI for each sample were used to derive the PCGI=2 + [PCLI-(O.1)(PCAI)]. The median PCGI for patients with inactive disease (MGUS, SMM/IMM or amyloidosis) was 1.8 compared to 2.4 for those with active disease (new or relapsed MM) (P<0.001). These results suggest that a decrease in the PCAI may be a factor in the progression from MGUS to SMM to overt MM.
Identification of Compounds with Anti-West Nile Virus Activity (2006)

The lack of antiviral compounds targeting flaviviruses represents a significant problem in the development of strategies for treating West Nile Virus (WNV), Dengue, and Yellow Fever infections. Using WNV high-throughput screening techniques developed in our laboratories, we report the identification of several small molecule anti-WNV compounds belonging to four different structural classes including pyrazolines, xanthanes, acridines, and quinolines. The initial set of "hits" was further refined using cell viability-cytotoxicity assays to two 1,3,5-triaryl pyrazoline compounds: 1-(4-chlorophenylacetyl)-5-(4-nitrophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole and 1-benzoyl-5-(4-chlorophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole. On the basis of their activity and favorable therapeutic indexes, these compounds were identified as viable leads and subjected to additional evaluation using an authentic viral titer reduction assay employing an epidemic strain of WNV. The compounds were further evaluated in a transient replicon reporting system to gain insight into the mechanism of action by identifying the step at which inhibition takes place during viral replication. The results indicate the pyrazolines inhibit RNA synthesis, pointing to viral RNA polymerase, RNA helicase, or other viral replication enzymes as potential targets. Progress was also made in understanding the structural requirements for activity by synthesizing a focused chemical library of substituted pyrazolines. Preliminary SAR data are presented that show the aryl-rings are required for activity against WNV. More importantly, the results indicate WNV activity is tolerant to aryl-substitutions paving the way for the design and development of much larger combinatorial libraries with varied physicochemical properties.
An Adaptive Frequency Hopping TechniqueWith Application to Bluetooth-WLAN Coexistence (2006)

In this paper, a new adaptive frequency hopping (AFH) technique is proposed in an attempt to mitigate the interference between Bluetooth (IEEE 802.15) and wireless local area networks (WLANs) (IEEE 802.11b). The new AFH technique optimizes the carrier spacing according to the network load and noise level. For a given overall bandwidth and data rate, reducing the separation between adjacent channels has a positive effect of increasing the number of available hopping channels. This can definitely lead to decreasing the collision rate. On the other hand, decreasing the channel spacing increases the adjacent channel interference. Therefore, there exists an optimal channel spacing that maximizes the network throughput. Rayleigh fading was considered and results show that the new AFH technique outperforms existing AFH techniques for a wide range of network loads.
Diffserv’s Assured Forwarding PHB: What Assurance does the Customer Have? (1999)

This paper examines issues related to assuring the throughput performance parameters of a Service Level Agreement in an Assured Forwarding based Diffserv-capable IP network. In an effort to understand the kinds of quantifiable parameters that can be included in a contract, the analysis of detailed studies on throughput are presented. Seven different factors are discussed which can bias bandwidth assurance for equal paying customers. Design options for various Traffic Conditioning schemes at the edge of the network to mitigate the effect of these factors are also discussed. The scope of network for which such schemes are viable is assessed. There are open issues that need to be addressed before such schemes can achieve their desired effect on the general Internet.
Small molecule interleukin-8 modulators (2001)

The correlation between the production of IL-8, along with many chemokines and inflammatory diseases, has been well documented. Therefore, modulation of IL-8 production is a viable approach to drug discovery for the treament of inflammatory diseases. Two general approaches to regulate IL-8 production are most prevalent. One is direct inhibition of IL-8 receptors, CXCR1 and/or CXCR2. The other is downstream regulation of IL-8 production via inhibition of p38 kinase. This review accounts the patent literature published between 1998 and 2001, covering small molecule IL-8 modulators using both approaches.
Synthesis of Glycosphingolipids and Psychosines (1986)

As components of biological membranes, glycolipids are of great importance. By reversing the usual order of steps in the synthesis, the yields obtained by a known method have been dramatically improved: the azidosphingosine and not the ceramide is glycosylated first by means of the trichloroacetimidate method. O-Glucopsychosine (1, NH2 instead of NHCOC15H31) can thereby be facilely acylated to give the glucocerebroside 1.
Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs. (1988)

The mRNAs for the heavy and light subunits of the iron-storage protein ferritin occur in cells largely as inactive ribonucleoprotein particles, which are recruited for translation when iron enters the cell. Cytoplasmic extracts from rat tissues and hepatoma cells were shown by an electrophoretic separation procedure to form RNA-protein complexes involving a highly conserved sequence in the 5' untranslated region of both ferritin heavy- and light-subunit mRNAs. The pattern of complex formation was affected by pretreatment of rats or cells with iron. Crosslinking by UV irradiation showed that the complexes contained an 87-kDa protein interacting with the conserved sequence of the ferritin mRNA. We propose that intracellular iron levels regulate ferritin synthesis by causing changes in specific protein binding to the conserved sequence in the ferritin heavy- and light-subunit mRNAs.
Classifying construction site photos for roof detection (2016)

Purpose Roofing is one of the most dangerous jobs in the construction industry. Due to factors such as lack of planning, training and use of precaution, roofing contractors and workers continuously violate the fall protection standards enforced by the US Occupational Safety and Health Administration. A preferable way to alleviate this situation is automating the process of non-compliance checking of safety standards through measurements conducted in site daily accumulated videos and photos. As a key component, the purpose of this paper is to devise a method to detect roofs in site images that is indispensable for such automation process. Design/methodology/approach This method represents roof objects through image segmentation and visual feature extraction. The visual features include colour, texture, compactness, contrast and the presence of roof corner. A classification algorithm is selected to use the derived representation for statistical learning and detection. Findings The experiments led to detection accuracy of 97.50 per cent, with over 15 per cent improvement in comparison to conventional classifiers, signifying the effectiveness of the proposed method. Research limitations/implications This study did not test on images of roofs in the following conditions: roofs initially built without apparent appearance (e.g. structural roof framing completed and undergoing the sheathing process) and flat, barrel and dome roofs. From a standpoint of construction safety, while the present work is vital, coupling with semantic representation and analysis is still needed to allow for risk analysis of fall violations on roof sites. Originality/value This study is the first to address roof detection in site images. Its findings provide a basis to enable semantic representation of roof site objects of interests (e.g. co-existence and correlation among roof site, roofer, guardrail and personal fall arrest system) that is needed to automate the non-compliance checking of safety standards on roof sites.
Pressure and temperature dependence of tracer diffusion coefficients of methanol, ethanol, acetonitrile, and formamide in water (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPressure and temperature dependence of tracer diffusion coefficients of methanol, ethanol, acetonitrile, and formamide in waterAllan J. Easteal and Lawrence A. WoolfCite this: J. Phys. Chem. 1985, 89, 7, 1066–1069Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/j100253a004https://doi.org/10.1021/j100253a004research-articleACS PublicationsRequest reuse permissionsArticle Views847Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A Fast-Response Sliding-Mode Controller for Boost-Type Converters With a Wide Range of Operating Conditions (2007)

This paper proposes a fast-response sliding-mode controller for controlling boost-type converters requiring a fast dynamical response over a wide range of operating conditions. The various aspects of the controller, which include the method of generating the reference-current profile, the choice of sliding surface, the existence and stability properties, and the selection of the control parameters, are discussed. Experimental results are presented to validate the theoretical design and to illustrate the strength of the proposed controller. It is demonstrated that, with the proposed controller, the boost converter has a faster response and a lower voltage overshoot over a wide range of operating conditions as compared to that under the widely used peak current-mode controller. Moreover, it is easily realized with simple analog circuitries.
Intelligent stretching of ankle joints with contracture/spasticity (2002)

An intelligent stretching device was developed to treat the spastic/contractured ankle of neurologically impaired patients. The device stretched the ankle safely throughout the range of motion (ROM) to extreme dorsiflexion and plantarflexion until a specified peak resistance torque was reached with the stretching velocity controlled based on the resistance torque. The ankle was held at the extreme position for a period of time to let stress relaxation occur before it was rotated back to the other extreme position. Stretching was slow at the joint extreme positions, making it possible to reach a larger ROM safely and it was fast in the middle ROM so the majority of the treatment was spent in stretching the problematic extreme ROM. Furthermore, the device evaluated treatment outcome quantitatively in multiple aspects, including active and passive ROM, joint stiffness and viscous damping and reflex excitability. The stretching resulted in considerable changes in joint passive ROM, stiffness, viscous damping and reflex gain. The intelligent control and yet simple design of the device suggest that with appropriate simplification, the device can be made portable and low cost, making it available to patients and therapists for frequent use in clinics/home and allowing more effective treatment and long-term improvement.
Heteroduplex DNA formation is associated with replication and recombination in poxvirus-infected cells. (1991)

Poxviruses are large DNA viruses that replicate in the cytoplasm of infected cells and recombine at high frequencies. Calcium phosphate precipitates were used to cotransfect Shope fibroma virus-infected cells with different DNA substrates and the recombinant products assayed by genetic and biochemical methods. We have shown previously that bacteriophage lambda DNAs can be used as substrates in these experiments and recombinants assayed on Escherichia coli following DNA recovery and in vitro packaging. Using this assay it was observed that 2-3% of the phage recovered from crosses between point mutants retained heteroduplex at at least one of the mutant sites. The reliability of this genetic analysis was confirmed using DNA substrates that permitted the direct detection of heteroduplex molecules by denaturant gel electrophoresis and Southern blotting. It was further noted that heteroduplex formation coincided with the onset of both replication and recombination suggesting that poxviruses, like certain bacteriophage, make no clear biochemical distinction between these three processes. The fraction of heteroduplex molecules peaked about 12-hr postinfection then declined later in the infection. This decline was probably due to DNA replication rather than mismatch repair because, while high levels of induced DNA polymerase persisted beyond the time of maximal heteroduplex recovery, we were unable to detect any type of mismatch repair activity in cytoplasmic extracts. These results suggest that, although heteroduplex molecules are formed during the progress of poxviral infection, gene conversion through mismatch repair probably does not produce most of the recombinants. The significance of these observations are discussed considering some of the unique properties of poxviral biology.
Heat Pipe Integrated in Direct Bonded Copper (DBC) Technology for Cooling of Power Electronics Packaging (2006)

Thermal dissipation in power electronics systems is becoming an extremely important issue with the continuous growth of power density in their components. The primary cause of failure in this equipment is excessive temperatures in the critical components, such as semiconductors and transformers. This problem is particularly important in power electronic systems for space applications. These systems are usually housed in completely sealed enclosures for safety reasons. The effective management of heat removal from a sealed enclosure poses a major thermal-design challenge since the cooling of these systems primarily rely on natural convection. In this context, the presented paper treats the heat pipes as effective heat transfer devices that can be used to raise the thermal conductive path in order to spread a concentrated heat source over a larger surface area. As a result, the high heat flux at the heat source can be reduced to a smaller and manageable level that can be dissipated through conventional cooling methods. The objective of our work is to describe the feasibility of a cooling system with miniature heat pipes embedded in a direct bonded copper (DBC) structure. The advantage of this type of heat pipe is the possibility for implementation of the component layout on the heat pipe itself, which eliminates the existence of a thermal interface between the device and the cooling system
Relativistic klystron research for linear colliders (1988)

Relativistic klystrons are being developed as a power source for high gradient accelerator applications which include large linear electron-positron colliders, compact accelerators, and FEL sources. We have attained 200 MW peak power at 11.4 GHz from a relativistic klystron, and 140 MV/m longitudinal gradient in a short 11.4 GHz accelerator section. We report here on the design of our relativistic klystrons, the results of our experiments so far, and some of our plans for the near future. 5 refs., 9 figs., 1 tab.