gebhart/patrepeval huggingface dataset:
<i>In vivo and in vitro</i> immunological cross‐reactions between basic encephalitogen and synthetic basic polypeptides capable of suppressing experimental allergic encephalomyelitis (1973)

Abstract A significant extent of immunological cross‐reactivity has been demonstrated between the basic encephalitogenic protein of bovine origin and several synthetic amino acid copolymers which have suppressive effect on experimental allergic encephalomyelitis (EAE). This cross‐reactivity has been conclusively established on the cellular level, both in vivo by means of delayed hypersensitivity skin tests and in vitro using transformation of sensitized lymphocytes, as measured by incorporation of radioactive thymidine. The in vitro experiments have been conducted with lymph node cells from guinea pigs of both random bred and inbred strains, and on spleen and lymph node cells from rabbits. Definite cross‐reactivity was observed between the basic encephalitogen and all the synthetic copolymers which were previously shown effective in suppression of EAE, whereas ineffective copolymers or unrelated proteins did not show any cross‐reactivity. In the case of strain 2 guinea pigs and rabbit lymph node cells the cross‐reactivity in vitro was manifested by direct cross‐stimulation of the lymphocytes, whereas in random‐bred or strain 13 guinea pigs and rabbit spleen cells, the cross‐reaction was detected only by means of specific inhibition of the homologous stimulation by the heterologous antigen. A limited extent of cross‐reactivity was observed on the humoral level as well; antibodies provoked in guinea pigs against the synthetic copolymer Cop 1 cross‐reacted in the passive cutaneous anaphylaxis assay with the bovine basic encephalitogen.
The Jack and Snowshoe Rabbits as Swimmers (1925)

The Jack and Snowshoe Rabbits as Swimmers Get access Charles Eugene Johnson Charles Eugene Johnson New York State College of Forestry, Syracuse, New York Search for other works by this author on: Oxford Academic Google Scholar Journal of Mammalogy, Volume 6, Issue 4, November 1925, Pages 245–249, https://doi.org/10.2307/1373411 Published: 01 November 1925
Topology and subcellular localization of FtsH protein in Escherichia coli (1993)

FtsH protein in Escherichia coli is an essential protein of 70.7 kDa (644 amino acid residues) with a putative ATP-binding sequence. Western blots (immunoblots) of proteins from fractionated cell extracts and immunoelectron microscopy of the FtsH-overproducing strain showed exclusive localization of the FtsH protein in the cytoplasmic membrane. Most of the FtsH-specific labeling with gold particles was observed in the cytoplasmic membrane and the adjacent cytoplasm; much less was observed in the outer membrane and in the bulk cytoplasm. Genetic analysis by TnphoA insertions into ftsH revealed that the 25- to 95-amino-acid region, which is flanked by two hydrophobic stretchs, protrudes into the periplasmic space. From these results, we concluded that FtsH protein is an integral cytoplasmic membrane protein spanning the membrane twice and that it has a large cytoplasmic carboxy-terminal part with a putative ATP-binding domain. The average number of FtsH molecules per cell was estimated to be approximately 400.
Mean Absolute Relative Difference of Blood Glucose Monitoring Systems and Relationship to ISO 15197 (2021)

There is a threshold MARD that may allow an estimate whether ISO 15197 requirements are fulfilled, but this statement cannot be made with certainty.
Default logic as a query language (1997)

Research in nonmonotonic reasoning has focused largely on the idea of representing knowledge about the world via rules that are generally true but can be defeated. Even if relational databases are nowadays the main tool for storing very large sets of data, the approach of using nonmonotonic AI formalisms as relational database query languages has been investigated to a much smaller extent. In this work, we propose a novel application of Reiter's default logic by introducing a default query language (DQL) for finite relational databases, which is based on default rules. The main result of this paper is that DQL is as expressive as SO/sub /spl exist//spl forall// the existential-universal fragment of second-order logic. This result is not only of theoretical importance: We exhibit queries-which are useful in practice-that can be expressed with DQL and cannot with other query languages based on nonmonotonic logics such as DATALOG with negation under the stable model semantics. In particular, we show that DQL is well-suited for diagnostic reasoning.
A high repetition rate nanosecond pulsed power supply for nonthermal plasma generation (2005)

The basic principles of high repetition rate nanosecond pulsed power supplies, the design, and the implementation are presented. Voltage pulses of 20-30 kV with a rise time of 30 ns, a pulse duration of 200 ns, a pulse repetition rate of 1-2 kHz, an energy per pulse of 0.5-1 J, and the average power up to 0.5-1 kW have been achieved with total energy conversion efficiency of 90%. The protective circuit against overvoltage and the measurement of high-voltage output are described.
Serum pharmacology of amphotericin B applied in lipid emulsions (1997)

Application of amphotericin B in lipid emulsions (AmB/L) reduced membrane toxicity in vitro and decreased amphotericin B-associated toxic side effects in vivo when compared to that of amphotericin B applied in 5% glucose (AmB/G). Therefore, a comparative analysis of the pharmacological parameters of AmB/L and AmB/G was performed. Thirteen patients were analyzed, and nine of these patients received a subsequent treatment with AmB/G and AmB/L. In patients in both treatment groups amphotericin B showed a biphasic elimination from serum, with a prolonged terminal half-life of approximately 27 h. Patients treated with AmB/L showed significantly lower peak concentrations (44.2%; P = 0.008) and correspondingly lower area under the drug concentration-time curve (AUC) values (64.3%; P = 0.015) compared to the values for the same patients treated with AmB/G at a dose range of 0.6 to 1.5 mg/kg of body weight. The enhanced clearance of AmB/L may be due to a faster initial elimination of amphotericin B-lipid aggregates by the reticuloendothelial system. Lower peak concentrations and AUC values in serum and a correspondingly faster deposition of AmB/L in tissues may at least partly explain the lower toxicity of AmB/L. A comparative pharmacokinetic analysis with data for a single patient treated with AmB/L demonstrated that hemodialysis did not significantly affect the disposition of amphotericin B.
Elimination reactions. III. Hofmann elimination in cyclic compounds (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElimination reactions. III. Hofmann elimination in cyclic compoundsManning P. Cooke Jr. and James L. CokeCite this: J. Am. Chem. Soc. 1968, 90, 20, 5556–5561Publication Date (Print):September 1, 1968Publication History Published online1 May 2002Published inissue 1 September 1968https://pubs.acs.org/doi/10.1021/ja01022a043https://doi.org/10.1021/ja01022a043research-articleACS PublicationsRequest reuse permissionsArticle Views560Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Can injured adult CNS axons regenerate by recapitulating development? (2017)

In the adult mammalian central nervous system (CNS), neurons typically fail to regenerate their axons after injury. During development, by contrast, neurons extend axons effectively. A variety of intracellular mechanisms mediate this difference, including changes in gene expression, the ability to form a growth cone, differences in mitochondrial function/axonal transport and the efficacy of synaptic transmission. In turn, these intracellular processes are linked to extracellular differences between the developing and adult CNS. During development, the extracellular environment directs axon growth and circuit formation. In adulthood, by contrast, extracellular factors, such as myelin and the extracellular matrix, restrict axon growth. Here, we discuss whether the reactivation of developmental processes can elicit axon regeneration in the injured CNS.
A magnesium tetraphenylaluminate battery electrolyte exhibits a wide electrochemical potential window and reduces stainless steel corrosion (2014)

Using Al(OPh)<sub>3</sub> rather than the typical AlCl<sub>3</sub> with Grignard reagents affords a Mg-ion electrolyte with a reduced chloride content to enhance the stability on stainless steel.
Comparative genomics of Clostridium bolteae and Clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants (2016)

Genomic comparison of C. bolteae and C. clostridiofrome revealed functional differences in butyrate pathways and in flagellar systems, which play a critical role within human microbiota. Most of the resistance genes detected in both species were previously characterized in other bacterial species. A few of them were related to antibiotics inactive against Clostridium spp. Some were part of mobile genetic elements suggesting that these commensals of the human microbiota act as reservoir of antimicrobial resistances.
Cardioprotective Effects of Defibrotide in Acute Lethal and Nonlethal Myocardial Ischemia in the Cat (1986)

We evaluated the effects of defibrotide (D), a natural profibrinolytic and antithrombotic agent with endogenous PGI2-stimulating properties, on acute lethal and nonlethal myocardial ischemia (L-AMI and NL-AMI) in the cat. The coronary artery was occluded at 12-14 mm from its origin. In L-AMI, 12 of 15 control cats developed ventricular fibrillation and died; D (32 mg kg-1, bolus intravenously plus infusion) provided total protection against death and showed protective effects on plasma and myocardial creatine phosphokinase (CPK), hemodynamics and ECG. In NL-AMI, pretreatment of cats with D at the same dosage (intravenous infusion) reduced AMI-ST segment increases and AMI changes in hemodynamics. AMI-induced changes in lactate adenosine triphosphate and CPK in ischemic tissues were prevented by D. The beneficial effects of D in NL-AMI could be partly attributed to its stimulatory effect on vascular PGI2 release; the mechanism of the impressive protection by D observed in L-AMI has still to be elucidated.
The First Catalytic Synthesis of an Acrylate from CO<sub>2</sub> and an Alkene—A Rational Approach (2012)

For more than three decades the catalytic synthesis of acrylates from the cheap and abundantly available C(1) building block carbon dioxide and alkenes has been an unsolved problem in catalysis research, both in academia and industry. Herein, we describe a homogeneous catalyst based on nickel that permits the catalytic synthesis of the industrially highly relevant acrylate sodium acrylate from CO(2), ethylene, and a base, as demonstrated, at this stage, by a turnover number of greater than 10 with respect to the metal.
Blind reconstruction of non-minimum-phase systems from 1-D oblique slices of bispectrum (1999)

The author considers the problem of identifying a non-minimum-phase signal from one-dimensional slices of its output bispectra. It is proved that any single slice of the bispectrum carries sufficient information to estimate the impulse response of a complex valued system within a time shift, as long as the chosen slice is not parallel to any one of the frequency axes or to the diagonal at 135 degrees. The author also derives identifiability criteria associated with complex-valued signals that admit finite-dimensional ARMA representations. One-dimensional techniques are proposed for signal reconstruction from bispectrum slices and their performance is investigated through Monte-Carlo simulations. The slices required for the proposed method can be estimated on a polar raster directly from observations, avoiding the heavy computational burden associated with cumulant estimates. The freedom to choose arbitrarily oriented and shifted slice(s) allows bispectrum regions dominated by larger estimation variance and higher noise to be avoided.
Location-Independent Scheduling Mechanism for Multi-hop Wireless Backhaul Networks (2007)

A common problem of a multi-hop wireless backhaul network (WBN) is the end-to-end throughput of a relay node is location-dependent. That is, the closest relay node to the gateway will get the most bandwidth. This paper presents a location-independent scheduling mechanism (LISM) for WBNs. LISM adopts a simple time-stamp-based approach to resolve the location-dependent problem and utilizes a dual-queue approach to minimize the sorting complexity. Simulation results indicate that LISM successfully solves the location-dependent problem.
Constructing and maintaining scientific database views in the framework of the object-protocol model (2002)

Scientific databases (ScDBs) are used to archive and retrieve data describing objects of scientific inquiry. Since these ScDBs must provide continuous and efficient access to large communities of scientists, they are often developed with reliable commercial relational database management systems (DBMSs) or file systems. However, relational DBMSs and flat files do not provide constructs for representing directly ScDB-specific objects and experimental procedures, and therefore they are often hard to develop, maintain, and explore. The authors present a retrofitting tool for constructing and maintaining ScDB views using an object-oriented data model, and describe their experience with retrofitting ScDBs that have been originally developed using relational DBMSs and file systems. The retrofitting tool is part of a data management toolkit based on the object-protocol model (OPM). The OPM toolkit provides facilities for developing databases defined using OPM and for querying and browsing such ScDBs in terms of OPM constructs. The OPM retrofitting tool allows constructing (one or several) OPM views for ScDBs that have not been originally developed with the OPM tools. ScDBs with native OPM schemas or retrofitted OPM views can be browsed and queried via OPM interfaces, reorganized, or incorporated into an OPM-based database federation.
Prospective validation of a low-back disorder risk model and assessment of ergonomic interventions associated with manual materials handling tasks (2000)

The evaluation of low-back disorder risk associated with materials handling tasks can be performed using a variety of assessment tools. Most of these tools vary greatly in their underlying logic, yet few have been assessed for their predictive ability. It is important to document how well an assessment tool realistically reflects the job's injury risk, since only valid and accurate tools can reliably determine whether a given ergonomic intervention will result in a future reduction in back injuries. The goal of this study was to evaluate how well a previously reported low-back disorder (LBD) risk assessment model (Marras et al. 1993) could predict changes in LBD injury rates as the physical conditions to which employees are exposed were changed. Thirty-six repetitive materials handling jobs from 16 different companies were included in this prospective cohort study. Of these 36 jobs, 32 underwent an ergonomic intervention during the observation period, and four jobs in which no intervention occurred served as a comparison group. The trunk motions and workplace features of 142 employees performing these jobs were observed both before and after workplace interventions were incorporated. In addition, the jobs' LBD rates were documented for these pre- and post-intervention periods. The results indicated that a statistically significant correlation existed between changes in the jobs' estimated LBD risk values and changes in their actual low-back incidence rates over the observation period. Linear and Poisson regression models also were developed to predict a change in a job's incidence rate and the number of LBD on ajob respectively, as a function of the job's risk change using this assessment model. Finally, this prospective study showed which ergonomic interventions consistently reduced the jobs' mean low-back incidence rates. These results support use of the LBD risk model to assess accurately a job's potential to lead to low-back injuries among its employees.
Mesostructure-Induced Selectivity in CO<sub>2</sub> Reduction Catalysis (2015)

Gold inverse opal (Au-IO) thin films are active for CO2 reduction to CO with high efficiency at modest overpotentials and high selectivity relative to hydrogen evolution. The specific activity for hydrogen evolution diminishes by 10-fold with increasing porous film thickness, while CO evolution activity is largely unchanged. We demonstrate that the origin of hydrogen suppression in Au-IO films stems from the generation of diffusional gradients within the pores of the mesostructured electrode rather than changes in surface faceting or Au grain size. For electrodes with optimal mesoporosity, 99% selectivity for CO evolution can be obtained at overpotentials as low as 0.4 V. These results establish electrode mesostructuring as a complementary method for tuning selectivity in CO2-to-fuels catalysis.
Synthesis of <i>β</i>-Aminophosphonates and -Phosphinates (2005)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of β-Aminophosphonates and -PhosphinatesFrancisco Palacios, Concepción Alonso, and Jesús M. de los SantosView Author Information Departamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco, Apartado 450, 01080 Vitoria, Spain Cite this: Chem. Rev. 2005, 105, 3, 899–932Publication Date (Web):February 11, 2005Publication History Received27 September 2004Published online11 February 2005Published inissue 1 March 2005https://pubs.acs.org/doi/10.1021/cr040672yhttps://doi.org/10.1021/cr040672yresearch-articleACS PublicationsCopyright © 2005 American Chemical SocietyRequest reuse permissionsArticle Views5326Altmetric-Citations317LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ethyl groups,Hydrolysis,Organic compounds,Organophosphorus compounds,Reaction products Get e-Alerts
Plasmas for spacecraft propulsion (2009)

This review presents the basics of plasma discharges applied to electric spacecraft propulsion. It briefly reports on the mature and flown technologies of gridded ion thrusters and Hall thrusters before exploring the recent yet immature technology of plasma thrusters based on expansion from low pressure high density inductively coupled and wave-excited plasma sources, e.g. the radiofrequency helicon source. Prototype development of plasma engines for future space travel is discussed using the example of the helicon double layer thruster. A summary of highlights in electric propulsion based space missions gives some insight into the challenges of future high power missions in more remote regions of space.
T Regulatory Lymphocytes Prevent Aldosterone-Induced Vascular Injury (2011)

Aldosterone mediates actions of the renin-angiotensin-aldosterone system inducing hypertension, oxidative stress, and vascular inflammation. Recently, we showed that angiotensin II-induced hypertension and vascular damage are mediated at least in part by macrophages and T-helper effector lymphocytes. Adoptive transfer of suppressor T-regulatory lymphocytes (Tregs) prevented angiotensin II action. We hypothesized that Treg adoptive transfer would blunt aldosterone-induced hypertension and vascular damage. Thirteen to 15-week-old male C57BL/6 mice were injected intravenously at 1-week intervals with 3×10(5) CD4(+)CD25(+) cells (representing Treg) or control CD4(+)CD25(-) cells and then infused or not for 14 days with aldosterone (600 μg/kg per day, SC) while receiving 1% saline to drink. Aldosterone induced a small but sustained increase in blood pressure (P<0.001), decreased vasodilatory responses to acetylcholine by 66% (P<0.001), increased both media:lumen ratio (P<0.001) and media cross-sectional area of resistance arteries by 60% (P<0.05), and increased NADPH oxidase activity 2-fold in aorta (P<0.001), kidney and heart (P<0.05), and aortic superoxide production. As well, aldosterone enhanced aortic and renal cortex macrophage infiltration and aortic T-cell infiltration (all P<0.05), and tended to decrease Treg in the renal cortex. Treg adoptive transfer prevented all of the vascular and renal effects induced by aldosterone. Adoptive transfer of CD4(+)CD25(-) cells exacerbated aldosterone effects except endothelial dysfunction and increases in media:lumen ratio of resistance arteries. Thus, Tregs suppress aldosterone-mediated vascular injury, in part through effects on innate and adaptive immunity, suggesting that aldosterone-induced vascular damage could be prevented by an immunomodulatory approach.
Fine-Tuning StyleGAN2 For Cartoon Face Generation (2021)

Recent studies have shown remarkable success in the unsupervised image to image (I2I) translation. However, due to the imbalance in the data, learning joint distribution for various domains is still very challenging. Although existing models can generate realistic target images, it's difficult to maintain the structure of the source image. In addition, training a generative model on large data in multiple domains requires a lot of time and computer resources. To address these limitations, we propose a novel image-to-image translation method that generates images of the target domain by finetuning a stylegan2 pretrained model. The stylegan2 model is suitable for unsupervised I2I translation on unbalanced datasets; it is highly stable, produces realistic images, and even learns properly from limited data when applied with simple fine-tuning techniques. Thus, in this paper, we propose new methods to preserve the structure of the source images and generate realistic images in the target domain. The code and results are available at https://github.com/happy-jihye/Cartoon-StyleGan2