gebhart/patrepeval huggingface dataset:
Tailor-made Data Management - A Challenge for Database Technology? (2009)

The need for tailor-made data management is apparent in database research. There is an impressive body of research on extensible or customizable DBMS like kernel systems or component DBMS. Nevertheless, all these approaches have drawbacks, e.g., regarding customizability or performance, and there is no general solution for efficient development of tailorable DBMS. Novel software engineering techniques (e.g, software product lines and feature-oriented programming), can help in developing customizable DBMS and reduce the complexity of building variable solutions as we could show for embedded systems [2]. Applying such an approach to other domains like stream processing, column stores, XML databases, etc. is promising to create DBMS that provide only needed functionality, can be better tuned and maintained, and provide reuse within a domain and even between different domains. Customizability is also required on the level of the query language, i.e., SQL, which grows with every new standard. Independent of the actual task, which may be as simple as querying a single value, developers are confronted with the full arsenal of SQL. Furthermore, applications only use a small subset of the standard and require special extensions, e.g., for sensor networks or stream processing. This results in SQL dialects that are used in different domains and are decoupled from the SQL standard. We could show that SQL (i.e., the grammar and the parser) can be decomposed with a feature-oriented approach. This results in a family of SQL dialects from which tailor-made SQL parsers, e.g., for sensor networks, can be generated [1]. By combining tailor-made SQL dialects and customizable DBMS we think that one can build DBMS that can be fully tailored to an application domain or a special use case within a domain while providing high reuse. Creating such fully customizable systems is a highly challenging task. It involves customizability on all levels of a DBMS such as the query processor and optimizer, the transaction subsystem, or the storage system. Because of interdependencies between those subsystems an architecture has to be developed that is able to handle the resulting complexity. For example, changing the query language affects the whole DBMS including the query optimizer which is highly connected with all other parts of a DBMS. New extensibility mechanisms as provided by feature-oriented programming can help in building such variable systems. However, this is probably not sufficient and the community has to investigate in an architecture and new mechanisms for handling the variability that keep maintainability and performance of DBMS.
Simultaneous multifrequency inversion of full-waveform seismic data (2009)

Abstract We present a simultaneous multifrequency inversion approach for seismic data interpretation. This algorithm inverts all frequency data components simultaneously. A data-weighting scheme balances the contributions from different frequency data components so the inversion process does not become dominated by high-frequency data components, which produce a velocity image with many artifacts. A Gauss-Newton minimization approach achieves a high convergence rate and an accurate reconstructed velocity image. By introducing a modified adjoint formulation, we can calculate the Jacobian matrix efficiently, allowing the material properties in the perfectly matched layers (PMLs) to be updated automatically during the inversion process. This feature ensures the correct behavior of the inversion and implies that the algorithm is appropriate for realistic applications where a priori information of the background medium is unavailable. Two different regularization schemes, an L2-norm and a weighted L2-norm function, are used in this algorithm for smooth profiles and profiles with sharp boundaries, respectively. The regularization parameter is determined automatically and adaptively by the so-called multiplicative regularization technique. To test the algorithm, we implement the inversion to reconstruct the Marmousi velocity model using synthetic data generated by the finite-difference time-domain code. These numerical simulation results indicate that this inversion algorithm is robust in terms of starting model and noise suppression. Under some circumstances, it is more robust than a traditional sequential inversion approach.
Effect of Lifelong Coenzyme Q10 Supplementation on Age-Related Oxidative Stress and Mitochondrial Function in Liver and Skeletal Muscle of Rats Fed on a Polyunsaturated Fatty Acid (PUFA)-Rich Diet (2007)

This study investigates aging-related changes in lipid peroxidation and functionality in liver and skeletal-muscle mitochondria in rats fed a diet rich in polyunsaturated fatty acids (PUFA), depending on supplementation or not with coenzyme Q(10) (CoQ(10)). Two groups of rats were fed for 24 months on a PUFA-rich diet, differing in supplementation or not with CoQ(10). At 6 and 24 months mitochondria were analyzed for fatty acid profile; hydroperoxides; alpha-tocopherol; CoQ(9;) CoQ(10;) cytochromes b, c+c(1), and a+a(3) contents; cytochrome c oxidase activity; and catalase activity in cytosol. Results of this study showed for the supplemented group an age-associated decrease in the peroxidizability index, an increase in catalase activity in skeletal muscle, and modulation of the aging-related changes in different mitochondrial electron-transport-chain components in skeletal muscle. These findings provide mechanisms to explain the effect of CoQ(10) in extending the life span of animals fed a PUFA-rich diet.
High Temperature Measurements for On-Board Diagnostics of LEV/ULEV Systems (1994)

<div class="htmlview paragraph">High temperature exhaust gas sensors have been used since 1975 to monitor catalyst overtemperature in the Japan auto market. Heated catalyst systems introduced to meet LEV and ULEV will make use of high temperature sensors for control and diagnosis. This paper describes the history and the evolution of these sensors. The three leading sensor technologies consisting of thermistors, thermocouples, and resistive temperature detectors (RTD) are described. Interface and system requirements for each of the sensor technologies are summarized. Sensor response time characteristics interaction with system design are covered.</div>
Factors that can Influence and Control the Emissions of Dioxins and Furans from Hazardous Waste Incinerators (1991)

The European Economic Community (EEC) has proposed strict limits on emissions of dioxins and furans from hazardous waste incinerators. The proposed limit is 0.1 ng/Nm3, expressed as the 2,3,7,8 TCDD toxic equivalent of 17 specific dioxin and furan congeners. These limits will potentially redefine technology selection and design for combustion, energy recovery, and air pollution control. The EPA has a different approach for controlling emissions of products of incomplete combustion (PICs) and reformation products such as dioxins and furans. Rather than limiting these contaminants individually and quantitatively, EPA proposes controlling them by assuring good combustion as measured by stack emissions of carbon monoxide (CO) and total hydrocarbons (THC). Dioxins and furans are combustion by-products and emission control relies mainly on control of the combustion process. These compounds can also be reformed from certain precursor compounds and elements in lower temperature regions of the system downstream of the combustion process. Air pollution control technologies have demonstrated the ability to remove dioxins and furans as contaminants on fine particulate. This paper will discuss the two regulatory approaches, the mechanisms for the formation and reformation of dioxins and furans, and the technologies available to control emissions.
Cardiovascular drugs and sexuality: a cardiologist's review (1980)

• In evaluating the factors of sexual dysfunction of the cardiovascular patient, the impact of drugs should be considered. Cardiovascular drugs may affect the sexuality of the patient through their effects on the CNS and peripheral nervous system, the vascular system, and hormonal changes. Such agents may impair the libidinal, erectile, and orgasmic phases of the human sexual response or may have effects that indirectly affect sexuality. Adrenergic inhibiting drugs, diuretics, vasodilators, monoamine oxidase inhibitors, antiarrhythmics, hypolipidemics, and digitalis may affect the sexual response, with the former group having the most serious effects. These effects may interfere with the patient's compliance with medications, can cause emotional problems, and often have an undesirable impact on marital relations. Knowledge of the sexual side effects of the drugs and proper counseling of the patient are vital. (<i>Arch Intern Med</i>140:1341-1345, 1980)
Synthesis of Chiral α-Amino Tertiary Boronic Esters by Enantioselective Hydroboration of α-Arylenamides (2015)

The rhodium-catalyzed asymmetric hydroboration of α-arylenamides with BI-DIME as the chiral ligand and (Bpin)2 as the reagent yields for the first time a series of α-amino tertiary boronic esters in good yields and excellent enantioselectivities (up to 99% ee).
The 120 kilodalton outer membrane protein (rOmp B) of <i>Rickettsia rickettsii</i> is encoded by an unusually long open reading frame: evidence for protein processing from a large precursor (1991)

A Rickettsia rickettsii outer surface membrane protein (rOmp B), of an apparent molecular mass of 120 kilodaltons, is a major surface antigen of the Rickettsiae that displays genus, species, and sub-species specific antigenic determinants. The 5' portion of this gene was found to be unstable in plasmids, but was stably cloned in a lambda vector. The nucleotide sequence of the 5' terminus has been determined, thus completing the DNA sequence of the entire gene. Genetic analysis revealed an unusually large open reading frame with the capacity to encode a product much larger than the mature protein. A 32 kilodalton peptide from purified rickettsiae was isolated and the amino terminus was sequenced, which revealed that the peptide is encoded by the 3' portion of this large open reading frame. This suggests a role for post-translational processing of rOmp B from a large precursor molecule.
Correlation between Cold- and Drought-Induced Frost Hardiness in Winter Wheat and Rye Varieties (1982)

Exposure of six wheat (Triticum aestivum L.) and one rye (Secale cereale L.) cultivar to 40% relative humidity for 24 hours induced the same degree of freezing tolerance in seedling epicotyls as did cold conditioning for 4 weeks at 2 degrees C.Frost hardiness varietal relationships were the same in desiccation-stressed and cold-hardened seedlings. Drought stress could, therefore, be used as a rapid and simple method for inducing frost hardiness in seedling shoots in replacement of cold conditioning.
Uterine contractility decreases at the time of blastocyst transfers (2001)

High-frequency uterine contractions at the time of non-cavitating embryo transfer influence adversely IVF-embryo transfer outcome. This prompted us to quantify prospectively the possible decline in uterine contraction frequency occurring during later stages of the luteal phase of ovarian stimulation, up to the time of blastocyst transfers, in 43 IVF-embryo transfer candidates. Contractility was assessed on the day of human chorionic gonadotrophin (HCG) administration, 4 days after HCG (non-cavitating embryo transfer; HCG + 4), and 7 days after HCG (blastocyst transfers; HCG + 7). For this, 2 min sagittal uterine scans were obtained by ultrasound and digitized with a computerized system for the assessment of uterine contraction frequency. Our results indicated that a slight, yet significant, decrease in uterine contraction frequency, observed from the day of HCG (4.4 +/- 0.2 contractions/min) to HCG + 4 (3.5 + 0.2 contractions/min), was followed by a more pronounced, additional decrease between HCG + 4 and HCG + 7 (1.5 +/- 0.2 contractions/min; P < 0.001). In conclusion, during the luteal phase of ovarian stimulation, uterine contractility decreases progressively, and reaches a nearly quiescent status 7 days after HCG administration, at the time of blastocyst transfers. It is possible that such a uterine relaxation assists blastocyst implantation.
Hierarchical user interest model based on large log data of mobile internet (2016)

The development of mobile internet brings a new perspective for user interest model. Mobile logs record more behaviors which can build a more comprehensive model for personalized service or recommendation system. Comparing the VSM and semantic network, we choose Concept Hierarchy to model user interest considering hierarchical granularity relations and make the user interest vivid and clear. In the background of large scale data, we analyze the characteristic of mobile internet and propose a mechanism based on session, so as to make the process of modeling linear and superimposed. In addition, we employ unsupervised learning method to avoid storing large historic data. At the end, we import time decay function and spreading activation model to trace the change of user interest. Experiential results confirm the feasibility and availability.
Old World Nonhuman Primate Models of Type 2 Diabetes Mellitus (2006)

Type 2 diabetes mellitus is a major health problem of increasing incidence. To better study the pathogenesis and potential therapeutic agents for this disease, appropriate animal models are needed. Old World nonhuman primates (NHPs) are a useful animal model of type 2 diabetes; like humans, the disease is most common in older, obese animals. Before developing overt diabetes, NHPs have a period of obesity-associated insulin resistance that is initially met with compensatory insulin secretion. When either a relative or absolute deficiency in pancreatic insulin production occurs, fasting glucose concentrations begin to increase and diabetic signs become apparent. Pathological changes in pancreatic islets are also similar to those seen in human diabetics. Initially there is hyperplasia of the islets with abundant insulin production typically followed by replacement of islets with islet-associated amyloid. Diabetic NHPs have detrimental changes in plasma lipid and lipoprotein concentrations, lipoprotein composition, and glycation, which may contribute to progression of atherosclerosis. As both the prediabetic condition (similar to metabolic syndrome in humans) and overt diabetes become better defined in monkeys, their use in pharmacological studies is increasing. Likely due to their genetic similarity to humans and the similar characteristics of the disease in NHPs, NHPs have been used to study recently developed agonists of the peroxisome proliferators-activated receptors. Importantly, agonists of the different receptor subclasses elicit similar responses in both humans and NHPs. Thus, Old World NHPs are a valuable animal model of type 2 diabetes to study disease progression, associated risk factors, and potential new treatments.
Photoelectrochemical Biosensors for Nucleic Acid Detection (2014)

A biosensor for detection of nucleic acids employs, as the sensing element, an oligonucleotide, with a known sequence of bases that can be used to detect specific DNA/RNA sequences through the hybridization reaction (this kind of biosensor is also called a genosensor). Many different transducers can be used in the development of a genosensor. Recently, with the emergence of novel photoelectrochemically active species and new detection schemes, photoelectrochemistry has received increasing attention in the field of biosensors. Advances in the development and applications of photoelectrochemical genosensors are reviewed in this article.
Variation in the electrophoretic karyotype analysed by the assignment of DNA probes in Candida albicans (1990)

By using pulsed-field gel electrophoresis, we have separated the entire chromosome bands and examined the electrophoretic karyotypes of 27 strains of Candida albicans. The electrophoretic karyotype varied widely among these strains. Their chromosomal DNAs were resolved into 7-12 bands ranging in size from 042 to 30 Mb. Most of the separated chromosomal bands were assigned by eight cloned C. albicans DNA probes. These results suggest that the haploid number of C. albicans chromosomes is eight. Each of the probes hybridized specifically to one or two bands of similar size in most strains. With the exception of the MGL1 probe, when two bands were detected by one probe, the size of one of them was very conserved whilst the other was of fairly variable size. The sizes of the chromosome bands assigned by the MGL1 probe were much more variable. As C. albicans is considered to be a diploid organism, it is inferred that the karyotype polymorphism between strains is mainly derived from wide size heterogeneity in one of the homologous chromosomes. Furthermore, we have confirmed species-specific and strain-specific variation in medically important Candida species (C. stellatoidea, C. tropicalis, C. parapsilosis, C. krusei, C. guilliermondii, C. kefyr and C. glabrata). Electrophoretic karyotype analysis is thus useful for species assignation. The TUB2 probe, encoding C. albicans beta-tubulin, hybridized to the chromosomal DNA of all the Candida species examined, but four C. albicans probes exhibited cross-species hybridization with C. stellatoidea only. The karyotype of C. stellatoidea seems to be within the range of the intraspecies variation observed in C. albicans.
Central Effects of Long‐Term Relaxin Expression in the Rat (2005)

A recombinant adenovirus containing the human H2 preprorelaxin (hH2) cDNA and a reporter gene was coinjected with a transactivator virus (Ad-tTA) into the lateral cerebral ventricles of female rats. Cardiovascular effects were measured over a 21-day period. Circulating vasopressin in the periphery was significantly greater (P < .0001) in the relaxin-treated group throughout the experimental period, compared with controls. There was a significant decrease in plasma osmolality (P < .05) by approximately 10 mmol/L in the treated group by day 14. Immunofluorescence for hH2 present in cryosections showed rAd transduction and hH2 expression from ependymal cells of the ventricular system. Adenovirus-mediated delivery of hH2 to the brain is capable of producing bioactive relaxin that affects cardiovascular parameters.
Ethanol Metabolites: Their Role in the Assessment of Alcohol Intake (2015)

Depending on the biological material used for analysis, ethanol metabolites can be applied in different settings such as assessment of alcohol intake, screening, prevention, diagnosis, and therapy of alcohol use disorders.
Some ideas for further research in reproduction. (1970)

Comments are made on reproductive research problems in the hope that they may serve as a stimulus for effective research in the areas concerned. In studying the effects of drugs on the nerve elements involved in reproductive processes, no one has attempted to delineate the neural part of endometrial function, or to show if, or how it relates to the hormonal effect on the same tissues. Hysterectomy, removal of about 75% of the uterus, and the denervation of the guinea pig uterus greatly extend the life of the corpus luteum. If a luteolysin exists, the question of whether it relates to the parasympathetic control of uterine glandular epthelium, to the hormonal balance, or to both of these 2 functional entities remains to be answered. Clinicians indicate that women of reproductive age, who have been diagnosed as having a traumatic lumbar cord section, apparently have normal menstrual cycles, conceive, carry to full term, and have normal delivery. Further studies and statistics are needed to learn why this is true. The effect of vagotomy on gonadal function and morphology in the primate has not received careful consideration. Study of the effect of diet on the content of uterine luminal fluids has been neglected as has been the possibility that the contact of an IUD will change the secretion of the irritated glandular epithelium. Whether zygote implantation results from physical stimulation or a physiological process is unknown. No research data appear to exist that were taken directly from North American Indian women who are or have been habitual drinkers of an extract of Lithosperm ruderale which is said to reduce fertility. The effect of the celery plant, Apium graveolens, on the reproductive process is another area of study that might be undertaken.
Erratum to: The evaluation of yeast derivatives as adjuvant of the immune response to the Bm86 antigen in cattle: Correction (2001)

In the recent issue ofBMC Biotechnology 20011:2, Manuel Rodriguez Valle, Carlos Montero, Hector Machado and Marisdania Joglar published a paper entitled evaluation of yeast derivatives as adjuvant for the immune response to the Bm86 antigen in cattle [http:/ /www.biomedcentral.com/1472-6750/1/2] .This is the same paper that we prepared with them and submitted in 1998 to Experimental and Applied Acarology. The only changes in the manuscript were the title and format required by BMC Biotechnology.We were not informed about the submission or included as co-authors which, we believe, is an ethical violation of our scientific authorship. The manuscript that we submitted for publication in Experimental and Applied Acarology (Jose C. GarciaGarcia, Manuel Rodriguez Valle, Carlos Montero, Hector Machado, Marisdania Joglar and Jose de la Fuente Mouse as a predictive model for the evaluation of yeast derivatives as adjuvant of the immune response to the Bm86 antigen in cattle) was not accepted for publication at that time. We agreed to do additional experiments as suggested by the Editor of the journal, but soon after we relocated to the United States.
Re-examining the concept of severity in traumatic brain injury (1994)

This paper re-examines the theoretical concept of severe brain injury focusing on the duration of coma as a precise indicator of the clinical profile. A retrospective hospital chart study of 361 traumatic brain-injured patients was undertaken to determine the homogeneity of the subsample of the severely brain-injured (defined as 2 or more days of coma) with respect to the probability of four types of impairment: ataxia, contractures, paralysis and speech impairment. The current concept of severity assumes homogeneity among the 'severely brain-injured'. However, our results indicate significant differences in impairment within this population. The authors feel strongly that future studies must describe coma duration in finer gradations, and test for homogeneity within samples before inferences are made. Improvements in life-sustaining technologies have resulted in longer coma durations. The need to use coma days as an indicator of impairment rather than a broad category of severity is emphasized.
Electron Holography Surmounts Resolution Limit of Electron Microscopy (1995)

In high resolution electron off-axis holography, the complete information about amplitude and phase of the complex electron image wave is captured in a single hologram, fed to a computer, numerically reconstructed, and analyzed using methods of wave optical image processing. Specifically, the blurring effect due to the aberration of the objective lens of the electron microscope is corrected under reconstruction. The presented first results, achieved with a Philips CM30FEG electron microscope specially developed for the needs of high resolution electron holography, reveal that the point resolution of modern electron microscopes is significantly improved.
Relationship of c-myc Amplification to Progression of Breast Cancer From In Situ to Invasive Tumor and Lymph Node Metastasis (1993)

These results suggest that c-myc amplification can occur at an early stage in tumor progression and that amplification does not always persist in the nodal metastasis.