gebhart/patrepeval huggingface dataset:
Self-healing for autonomic pervasive computing (2007)

Self-healing is one of the main challenges to growing autonomic pervasive computing. Fault detection and recovery are the main steps of self-healing. Due to the characteristics of pervasive computing the self-healing becomes difficult. In this paper, the challenges of self-healing have been addressed and an approach to develop a self-healing service for autonomic pervasive computing is presented. The self-healing service has been developed and integrated into the middleware named MARKS+ (Middleware Adaptability for Resource discovery, Knowledge usability, and Self-healing). The self-healing approach is being evaluated on a test bed of PDAs. An application is being developed by using the proposed service.
Constrained evolvability of interferon suppression in an RNA virus (2016)

Innate immunity responses controlled by interferon (IFN) are believed to constitute a major selective pressure shaping viral evolution. Viruses encode a variety of IFN suppressors, but these are often multifunctional proteins that also play essential roles in other steps of the viral infection cycle, possibly limiting their evolvability. Here, we experimentally evolved a vesicular stomatitis virus (VSV) mutant carrying a defect in the matrix protein (M∆51) that abolishes IFN suppression and that has been previously used in the context of oncolytic virotherapy. Serial transfers of this virus in normal, IFN-secreting cells led to a modest recovery of IFN blocking capacity and to weak increases in viral fitness. Full-genome ultra-deep sequencing and phenotypic analysis of population variants revealed that the anti-IFN function of the matrix protein was not restored, and that the Mdelta51 defect was instead compensated by changes in the viral phosphoprotein. We also show that adaptation to IFN-secreting cells can be driven by the selection of fast-growing viruses with no IFN suppression capacity, and that these population variants can be trans-complemented by other, IFN-suppressing variants. Our results thus suggest that virus-virus interactions and alternative strategies of innate immunity evasion can determine the evolution of IFN suppression in a virus.
Design, Synthesis, and Biological Activity of a Family of Novel Ceramide Analogues in Chemoresistant Breast Cancer Cells (2009)

Resistance to chemotherapy and endocrine therapy is a major cause of breast cancer treatment failure. We have synthesized six novel analogues using C8-ceramide as the lead analogue and studied their effect on hormone therapy resistant (MDA-MB-231) and chemoresistant (MCF-7TN-R) breast cancer cells. Pharmacologic intervention using these ceramide analogues inhibited clonogenic survival and induced apoptosis, with one analogue being more effective than C8-ceramide. Our results show ceramide-based therapy has therapeutic potential in treating drug resistant breast cancer.
Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling (2002)

Heparan sulfates (HSs) exert critical regulatory actions on many proteins, including growth factors, and are essential for normal development. Variations in their specific sulfation patterns are known to regulate binding and signaling of fibroblast growth factors (FGFs) via tyrosine kinase receptors (FGFRs). We previously reported differences in sulfation patterns between HS species expressed by embryonic day 10 (E10) and E12 mouse neural precursor cells. We have examined the abilities of the different HS species to support signaling of the relevant FGF-FGFR combinations expressed early during brain development. For FGF8, which only functions early (E8-E11), E10 HS showed preferential activation. The most potent signaling for FGF8 was via FGFR3c, for which E10 HS was strongly active and E12 HS had no activity. For FGF2, which functions from E10 to E13, HS from both stages showed similar activity and were more potent at activating FGFR1c than the other receptors. Thus, we find a stage-specific correlation with activation. To explore the potential mechanisms for the generation of these stage-specific HS species, we investigated the expression of the HS sulfotransferase (HSST) isozymes responsible for creating diverse sulfation motifs in HS chains. We find that there are stage-specific combinations of HSST isozymes that could underlie the synthesis of different HS species at E10 and E12. Collectively, these data lead us to propose a model in which differential expression of HSSTs results in the synthesis of variant HS species that form functional signaling complexes with FGFs and FGFRs and orchestrate proliferation and differentiation in the developing brain.
Electromechanical Design and Construction of a Rotating Radio-Frequency Coil System for Applications in Magnetic Resonance (2012)

While recent studies have shown that rotating a single radio-frequency (RF) coil during the acquisition of magnetic resonance (MR) images provides a number of hardware advantages (i.e., requires only one RF channel, avoids coil-coil coupling and facilitates large-scale multinuclear imaging), they did not describe in detail how to build a rotating RF coil system. This paper presents detailed engineering information on the electromechanical design and construction of a MR-compatible RRFC system for human head imaging at 2 T. A custom-made (bladeless) pneumatic Tesla turbine was used to rotate the RF coil at a constant velocity, while an infrared optical encoder measured the selected frequency of rotation. Once the rotating structure was mechanically balanced and the compressed air supply suitably regulated, the maximum frequency of rotation measured ~14.5 Hz with a 2.4% frequency variation over time. MR images of a water phantom and human head were obtained using the rotating RF head coil system.
Vision-based absolute localization for unmanned aerial vehicles (2014)

This paper presents a method for localizing an Unmanned Aerial Vehicle (UAV) using georeferenced aerial images. Easily maneuverable and more and more affordable, UAVs have become a real center of interest. In the last few years, their utilization has significantly increased. Today, they are used for multiple tasks such as navigation, transportation or vigilance. Nevertheless, the success of these tasks could not be possible without a highly accurate localization which can, unfortunately be often laborious. Here we provide a multiple usage localization algorithm based on vision only. However, a major drawback with vision-based algorithms is the lack of robustness. Most of the approaches are sensitive to scene variations (like season or environment changes) due to the fact that they use the Sum of Squared Differences (SSD). To prevent that, we choose to use the Mutual Information (MI) which is very robust toward local and global scene variations. However, dense approaches are often related to drift disadvantages. Here, we solve this problem by using georeferenced images. The localization algorithm has been implemented and experimental results are presented demonstrating the localization of a hexarotor UAV fitted with a downward looking camera during real flight tests.
Round-robin scheduling for max-min fairness in data networks (1991)

The author studies a simple strategy, proposed independently by E.L. Hahne and R.G. Gallager (1986) and M.G.H. Katevenis (1987), for fairly allocating link capacity in a point-to-point packet network with virtual circuit routing. Each link offers its packet transmission slots to its user sessions by polling them in round-robin order. In addition, window flow control is used to prevent excessive packet queues at the network nodes. As the window size increases, the session throughput rates are shown to approach limits that are perfectly fair in the max-min sense. If each session has periodic input (perhaps with jitter) or has such heavy demand that packets are always waiting to enter the network, then a finite window size suffices to produce perfectly fair throughput rates. The results suggest that the transmission capacity not used by the small window session will be approximately fairly divided among the large window sessions. The focus is on the worst-case performance of round-robin scheduling with windows.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nonhomologous DNA end-joining for repair of DNA double-strand breaks (2017)

Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand break (DSB) repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of the S and G<sub>2</sub> phases. NHEJ relies on Ku to thread onto DNA termini and thereby improve the affinity of the NHEJ enzymatic components consisting of polymerases (Pol μ and Pol λ), a nuclease (the Artemis·DNA-PKcs complex), and a ligase (XLF·XRCC4·Lig4 complex). Each of the enzymatic components is distinctive for its versatility in acting on diverse incompatible DNA end configurations coupled with a flexibility in loading order, resulting in many possible junctional outcomes from one DSB. DNA ends can either be directly ligated or, if the ends are incompatible, processed until a ligatable configuration is achieved that is often stabilized by up to 4 bp of terminal microhomology. Processing of DNA ends results in nucleotide loss or addition, explaining why DSBs repaired by NHEJ are rarely restored to their original DNA sequence. Thus, NHEJ is a single pathway with multiple enzymes at its disposal to repair DSBs, resulting in a diversity of repair outcomes.
Dibenzo[a,e]cyclooctatetraene in a proposed test for heterogeneity in catalysts formed from soluble platinum-group metal complexes (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDibenzo[a,e]cyclooctatetraene in a proposed test for heterogeneity in catalysts formed from soluble platinum-group metal complexesDouglas R. Anton and Robert H. CrabtreeCite this: Organometallics 1983, 2, 7, 855–859Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/om50001a013https://doi.org/10.1021/om50001a013research-articleACS PublicationsRequest reuse permissionsArticle Views1993Altmetric-Citations356LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dependence of Sub-Micron Vaterite Container Release Properties on pH and Ionic Strength of the Surrounding Solution (2012)

We report on the synthesis and characterization of porous monodisperse vaterite containers with controllable average sizes from 400 nm to 10 μm. Possible release strategies of enclosed substances via recrystallization or by pH-change are presented. As a model experiment, a fluorescent marker was encapsulated and imaged by two-photon microscopy to monitor the dye release. The release process was found to be controllable via the immersion medium’s properties. Release times can be further tuned by covering the containers with additional polymer layers, creating a flexible system with promising perspectives for pharmaceutical applications.
Treatment of Organic-Contaminated Industrial Wastes Using Cement-Based Stabilization/Solidification— I. Microstructural Analysis of Cement-Organic Interactions (1991)

The major deficiencies in cement-based stabilization/solidification (S/S) processes are their inability to treat inorganic wastes contaminated with organic material or organic wastes. In general, organic compounds are poorly retained in a cement matrix and frequently have a detrimental, poorly understood, effect upon cement hydration and strength development. These interactions need to be understood as fully as possible, however, if S/S processes are to be developed in ways which will assure the long-term integrity of the resultant products. The work presented in this paper investigates some fundamental aspects of the interactions of two organic compounds, 3-chlorophenol and chloronaphthalene, with a cement matrix. Phenolic compounds have previously been shown to have a detrimental effect upon the macrostructural properties of ordinary Portland cement (OPC), for example, the strength, setting rate and leachability (Montgomery et al. 1988). Microstructural studies in this work have shown that 3-chlorophenol inhibits the hydration of tricalcium silicate (C 3 S in cement chemists' notation), with up to 90% of the C 3 S remaining after 28 days for highly dosed 3-chlorophenol/OPC samples. The formation of ettringite was found to be increased by the presence of 3-chlorophenol and its conversion to monosulphate inhibited. Scanning electron microscopy/energy dispersive spectroscopy (SEM/EDS) analysis of the samples showed that 3-chlorophenol crystallized in the cement matrix to form discrete crystals containing calcium and phenol. In contrast, chloronaphthalene had no observable effect on hydration reactions. In a subsequent paper, detailed studies will be presented showing how these deleterious effects can be minimized by the use of organophilic clays as a pre-solidification adsorbent.
Design modification of a solution-cathode glow discharge-atomic emission spectrometer for the determination of trace metals in titanium dioxide (2014)

The quantitative measurement of trace elements in TiO<sub>2</sub>powders using a modified solution-cathode glow discharge-atomic emission spectrometry system has been developed.
Peripheral Blood CD14+ Cells From Healthy Subjects Carry a Circular Conformation of Latent Cytomegalovirus Genome (1999)

The majority of the human population harbors latent cytomegalovirus. Although CD14(+) peripheral blood mononuclear cells have been implicated as sites of latency, the conformation of the latent viral genome in these cells is unknown. In this study, the conformation of viral genomic DNA was assessed in CD14(+) cells from healthy virus seropositive carriers using an electrophoretic separation on native agarose gels in combination with polymerase chain reaction detection. Here we show that the viral genome migrates as a circular plasmid with a mobility equivalent to a circular 230-kb Shigella flexneri megaplasmid marker. Neither linear nor complex or integrated forms of the viral genome were detected. This report provides further evidence that the CD14(+) cell population is an important site of viral latency in the naturally infected human host. Detection of the viral genome as a circular plasmid during latency suggests that this virus maintains its genome in a manner analogous to other herpesviruses where latent viral genome conformation has been studied.
Chemical Bridging for Well Control During Stimulation and Workover Operations (1991)

Abstract Oil field operators around the world are making increased use of polymer gel plugs to control wells and divert treating fluids during stimulation and workover operations. Use of this versatile method has eliminated the need in many cases for mechanical packers, bridge plugs and mechanical diverters. Benefits gained from use of gel plugs are usually economical; however, in many applications, gel plugs are used because mechanical devices may be undesirable. One method often used to obtain a temporary plug is to apply a water soluble polymer to a fluid which forms a highly viscous gel plug. These plugs can be designed to remain viscous for hours to several weeks. If time constraints change after the plug has been pumped, the plugs can be broken down with acid and removed ahead of schedule. This paper describes the chemistry of various gel plugs used at different temperatures and conditions in stimulation and workover operations. Several case histories detailing circumstances and conditions where various gel plugs have been applied are presented.
Cardiac contractility: Correction strategies applied to telemetry data from a HESI-sponsored consortium (2017)

Results suggest that the optimal correction formula for dP/dt<sub>max</sub> would be subject-specific, non-linear and would include HR and LV systolic pressure. Correcting contractility for HR and systolic LV pressure may enhance data interpretation in non-clinical drug safety assessments. Similar correction methods could be evaluated for other species used in safety pharmacology.
Distributed learning in mobile sensor networks using cross validation (2010)

Mobile sensor networks can increase sensing coverage both in space and time and robustness against dynamic changes in the environment, compared to stationary wireless sensor networks. For operations in a dynamic or unknown environment, mobile sensors need the capability of learning a suitable model during its operations. However, due to the limited communication bandwidth, it is prohibited to share all measurements with other mobile sensors. In this paper, we propose an efficient distributed learning algorithm based on cross validation for mobile sensor networks, which takes the advantage of a multi-agent system and minimizes the communication overhead while achieving excellent performance, and demonstrate its performance in simulation.
Human MCG measurements with a high-sensitivity potassium atomic magnetometer (2012)

Measuring biomagnetic fields, such as magnetocardiograms (MCGs), is important for investigating biological functions. To address to this need, we developed an optically pumped atomic magnetometer. In this study, human MCGs were acquired using a potassium atomic magnetometer without any modulating systems. The sensitivity of the magnetometer is comparable to that of high-T(c) superconducting quantum interference devices (SQUIDs) and is sufficient for acquiring human MCGs. The activity of a human heart estimated from the MCG maps agrees well with that measured with SQUID magnetometers. Thus, our magnetometer produces reliable results, which demonstrate the potential of our atomic magnetometer for biomagnetic measurements.
CNN-Based Patch Matching for Optical Flow with Thresholded Hinge Embedding Loss (2017)

Learning based approaches have not yet achieved their full potential in optical flow estimation, where their performance still trails heuristic approaches. In this paper, we present a CNN based patch matching approach for optical flow estimation. An important contribution of our approach is a novel thresholded loss for Siamese networks. We demonstrate that our loss performs clearly better than existing losses. It also allows to speed up training by a factor of 2 in our tests. Furthermore, we present a novel way for calculating CNN based features for different image scales, which performs better than existing methods. We also discuss new ways of evaluating the robustness of trained features for the application of patch matching for optical flow. An interesting discovery in our paper is that low-pass filtering of feature maps can increase the robustness of features created by CNNs. We proved the competitive performance of our approach by submitting it to the KITTI 2012, KITTI 2015 and MPI-Sintel evaluation portals where we obtained state-of-the-art results on all three datasets.
Beyond fixation durations: Recurrence quantification analysis reveals spatiotemporal dynamics of infant visual scanning (2018)

Standard looking-duration measures in eye-tracking data provide only general quantitative indices, while details of the spatiotemporal structuring of fixation sequences are lost. To overcome this, various tools have been developed to measure the dynamics of fixations. However, these analyses are only useful when stimuli have high perceptual similarity and they require the previous definition of areas of interest (AOIs). Although these methods have been widely applied in adult studies, relatively little is known about the temporal structuring of infant gaze-foraging behaviors such as variability of scanning over time or individual scanning patterns. Thus, to shed more light on the spatiotemporal characteristics of infant fixation sequences we apply for the first time a new methodology for nonlinear time-series analysis-the recurrence quantification analysis (RQA). We present how the dynamics of infant scanning varies depending on the scene content during a "pop-out" search task. Moreover, we show how the normalization of RQA measures with average fixation durations provides a more detailed account of the dynamics of fixation sequences. Finally, we link the RQA measures of temporal dynamics of scanning with the spatial information about the stimuli using heat maps of recurrences without the need for defining a priori AOIs and present how infants' foraging strategies are driven by the image content. We conclude from our findings that the RQA methodology has potential applications in the analysis of the temporal dynamics of infant visual foraging offering advantages over existing methods.
Interleukin‐1β impairment of transforming growth factor β1 signaling by DOWN‐REGULATION of transforming growth factor β receptor type II and up‐regulation of Smad7 in human articular chondrocytes (2007)

We demonstrate that IL-1beta impairs TGFbeta1 signaling through down-regulation of TGFbetaRII, which is mediated by the p65/NF-kappaB and activator protein 1/JNK pathways, and secondarily through the up-regulation of Smad7. These findings show that there is cross-talk in the signaling of 2 regulatory cytokines involved in inflammation.
Platelet–Monocyte Aggregates (2002)

hrombus formation within a coronary vessel is the precipitating event in unstable coronary syndromes.The angiographic severity of coronary stenoses may not predict sites of subsequent acute coronary events, inasmuch as rupture of atheromatous plaque with thrombosis in relatively mildly stenosed vessels may underlie many acute coronary syndromes.The intact endothelium normally prevents platelet activation, but the intimal injury associated with endothelial denudation and plaque rupture exposes subendothelial collagen and von Willebrand factor, which support prompt platelet adhesion and activation.Circulating platelets can adhere either directly to collagen or indirectly, via the binding of von Willebrand factor, to the glycoprotein Ib/IX complex.Local platelet activation promotes thrombus formation and additional platelet recruitment by supporting cell surface thrombin formation and releasing potent platelet agonists, such as adenosine 5Ј-diphosphate, serotonin, and thromboxane A 2 .The central role of platelet activation in acute coronary syndromes is supported by increased plateletderived thromboxane and prostaglandin metabolites detected in patients with acute coronary syndromes 1 and the clear clinical benefit of treatment with aspirin for prevention of acute coronary events.