gebhart/patrepeval huggingface dataset:
A Performance Trade-Off for the Insulated Gate Bipolar Transistor: Buffer Layer Versus Base Lifetime Reduction (1987)

A one-dimensional analytic model for the insulated gate bipolar transistor (IGBT), which includes a high-doped buffer layer in the low-doped bipolar transistor base, is developed. The model is used to perform a theoretical trade-off study between IGBT's with and without the buffer layer. The study is performed for devices of equal breakdown voltages, and the critical parameters chosen to ``trade-off'' are turn-off switching energy loss (related to turn-off time) and on-state voltage, both at a given current. In this model, as in reality, the two critical parameters are varied by 1) adjusting the doping concentration and thickness of a buffer layer included as part of the bipolar transistor base, 2) adjusting the lifetime in the lowly doped bipolar transistor base with no buffer layer included, or by 3) a combination of 1) and 2). The results of the model predict that for equal breakdown voltages an optimized device with a buffer layer has less switching energy loss for a given on-state voltage than an optimized device with no buffer layer.
Exploring In-Car Augmented Reality Navigation Aids: A Pilot Study (2009)

We evaluate the effects of in-car augmented reality navigation aids on driving performance and driver visual attention. Results from a pilot simulator study suggest that augmented reality navigation aids which overlay a route directly on the windshield are safer than today’s standard navigation aids.
PRODUCTION OF A BETACYANINE CONCENTRATE BY FERMENTATION OF RED BEET JUICE WITH Candida utilis (1976)

ABSTRACT Recent limitations on the use of artificial red food colorants has prompted extensive research into finding suitable natural red pigments as color additives. Investigations have shown that water‐based concentrates or powders of red beet root ( Beta vulgaris ) are applicable colorants in some food systems. However, presently available commercial beet preparations have relatively low pigment concentration; therefore, large quantities are required to obtain the desired color strength. Fermentation of ultrafiltered red beet juice by Candidu utilis under partial anaerobic conditions was shown to substantially reduce solids, resulting in a five‐ to sevenfold increase in betacyanine content on a dry basis. A 668% betacyanine content was achieved in the final dry product, The fermentable carbohydrate, nitrates and 80% of the Kjeldahl nitrogen were assimilated by Gmdida utilis after 6.5 hr of fermentation by maintaining the pH at 5.0 with NaOH and HCl solutions. After drying, the product lacked the characteristic beet flavor and aroma and was readily water soluble. This dry betacyanine concentrate may have application as a red food colorant.
Life/Style Online© a web-based methodology for visually-oriented consumer research (2000)

This paper describes a web-based data collection technique called Life/Style OnLine© that is suitable for a broad variety of consumer research applications. Unlike the majority of online research techniques now in use, respondents provide rapid-response feedback to stimuli presented primarily on the visual rather than the verbal channel. Following a brief review of current web-based research methods, we provide some details regarding the Life/Style OnLine© methodology, describe some alternative applications of its core functionalities, and explore the ramifications of this and similar web-based technologies for consumer research and marketing practice.
Spreadsheet Visualization Effects on Error Correction (2004)

Spreadsheets have been used by organizations for decades. Errors in spreadsheets are commonly found in laboratory and field findings. In recent years, many exciting new visualization techniques have been developed to help users understand spreadsheet models and to check for errors. Two visualization tools were tested in an experiment for their effects on error correction. The first is a simple arrow tool which shows dependencies among cells. The second shows the inputprocess- output function of cells in addition to the dependency arrows. The experiment shows significantly better error detection with the arrow method than for the plain method (without visualization tools). Wrong data errors took more time to correct than missing data errors.
The Application of Cross Correlation Technique for Estimating Impulse Response and Frequency Response of Wireless Communication Channel (2007)

Cross correlation technique is one of the most commonly used methods to estimate the channel impulse response such as a wireless communication channel. This paper looks at the use of two different types of signals that is applied in the cross correlation technique. The signals are phase shift keying (PSK) and linear FM signals (Chirps). Pseudo random sequence (PRS) is used in the generation of the PSK signals. The parameters of the PRS are varied according to the sequence lengths, sampling frequency and bit rate. From the cross correlation functions and the cross spectrum, the channel impulse response and channel frequency response are respectively estimated. Besides PSK signals, linear FM signal is also used as an input to estimate the channel impulse response. Both PSK and linear FM signals are chosen due to their auto correlation properties that are similar to an impulse function. Thus, the channel impulse response can be estimated based on the cross correlation between the output and the input signals. The desired and the estimated channel impulse responses and channel frequency response are respectively estimated and compared based on the mean squared error (MSE).
Separation of the Spectral Radiance Factor Curve of Fluorescent Substances into Reflected and Fluoresced Components (1973)

When a spectrophotometer with the correct optical configuration is used to measure a fluorescent sample, the resulting spectral radiance factor curve consists of the sum of a reflected and a fluoresced portion. The true reflectance curve can be obtained by direct measurement below the emission region and also above the absorption region by the use of a fluorescence-killing filter. Between these two limits, in the region of simultaneous absorption and emission (the crossover region), the true reflectance curve can be. obtained by calculation from two different spectral radiance factor curves and a single reading through the fluorescence-killing filter.
Amyloid‐β protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice (2009)

Oligomeric assemblies of amyloid-beta (Abeta) are suggested to be central in the pathogenesis of Alzheimer's disease because levels of soluble Abeta correlate much better with the extent of cognitive dysfunctions than do senile plaque counts. Moreover, such Abeta species have been shown to be neurotoxic, to interfere with learned behavior and to inhibit the maintenance of hippocampal long-term potentiation. The tg-ArcSwe model (i.e. transgenic mice with the Arctic and Swedish Alzheimer mutations) expresses elevated levels of Abeta protofibrils in the brain, making tg-ArcSwe a highly suitable model for investigating the pathogenic role of these Abeta assemblies. In the present study, we estimated Abeta protofibril levels in the brain and cerebrospinal fluid of tg-ArcSwe mice, and also assessed their role with respect to cognitive functions. Protofibril levels, specifically measured with a sandwich ELISA, were found to be elevated in young tg-ArcSwe mice compared to several transgenic models lacking the Arctic mutation. In aged tg-ArcSwe mice with considerable plaque deposition, Abeta protofibrils were approximately 50% higher than in younger mice, whereas levels of total Abeta were exponentially increased. Young tg-ArcSwe mice showed deficits in spatial learning, and individual performances in the Morris water maze were correlated inversely with levels of Abeta protofibrils, but not with total Abeta levels. We conclude that Abeta protofibrils accumulate in an age-dependent manner in tg-ArcSwe mice, although to a far lesser extent than total Abeta. Our findings suggest that increased levels of Abeta protofibrils could result in spatial learning impairment.
Preferential loss of expression of p16(INK4a) rather than p19(ARF) in breast cancer. (1996)

The tumor suppressor p16(INK4a) has been shown to be inactivated in numerous cancer lines and primary tumors. Recently, we reported loss of heterozygosity of the region in which p16(INK4a) is located in more than one-half of primary breast tumors. However, mutational analysis of these same tumors revealed mutation of p16(INK4a) to be infrequent. Other possible modes of inactivation, such as de novo methylation and homozygous deletion, have since been shown to occur in numerous neoplasias. Furthering the complexity of this locus, a transcript overlapping the p16(INK4a) coding sequence and encoding a novel peptide with growth-suppressive activity, p19(ARF), has been described. To clearly elucidate the target of aberrations affecting this subchromosomal region and approximate frequency in breast cancer, we performed a comprehensive study including p16 deletion analysis by means of interphase chromosomal fluorescence in situ hybridization, methylation analysis of the first exon encoding p16(INK4a) (exon 1alpha), mutational analysis of exon 1beta by single-strand conformational polymorphism analysis of p19(ARF) transcripts, and expression of both alpha and beta transcripts by reverse transcription PCR. Homozygous deletion of p16, as determined by interphase chromosomal fluorescence in situ hybridization, was observed in 3 of 18 (17%) tumors analyzed, whereas de novo methylation of exon 1alpha was observed in an additional 17% (4 of 23). Reduced expression of p16(INK4a) was observed in 11 tumors (48%), including all those in which homozygous deletion or complete methylation was observed. No mutations of exon 1 beta were detected, and expression of its transcript was variable, with 13% demonstrating decreased expression and 17% demonstrating overexpression. These results further support p16(INK4a) as a target of inactivation in the 9p21 region for breast cancer.
Effect of Foot Morphology on Center-of-Pressure Excursion During Barefoot Walking (2008)

These results indicate the importance of assessing foot posture when measuring center of pressure and may help explain regional differences in pain and injury location among foot types.
A 5 inch diameter position-sensitive scintillation counter (1993)

Recent developments in photomultiplier technology have enabled the construction of 5-in-diameter position-sensitive scintillation counters. A 5-in-diameter hard X-ray imager has been built and a position resolution of 4.0 mm full width half maximum (FWHM) has been obtained at 122 keV using a standard 3-mm-thick, 125-mm-diameter NaI(Tl) crystal with a 100-mm-diameter exit window. The spatial resolution can be improved by making some simple changes in the crystal design. The results show that the light output and spatial resolution vary considerably over the surface of such a detector. In order to make the best use of the imaging capability of these tubes, individual photon events must be corrected both in energy and position. The results of a 300-point detailed survey of the characteristics of the position-sensitive detector demonstrate its overall performance. A thyroid phantom image was obtained using this imager.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Gastric myoelectrical activity in patients with gastric outlet obstruction and idiopathic gastroparesis (1998)

Gastric myoelectrical patterns recorded in the EGG distinguish mechanical and idiopathic causes of gastroparesis and may be useful in evaluating patients with nausea, vomiting, and gastroparesis of unknown cause.
Constitutive Delivery of Bovine β-Lactoglobulin to the Digestive Tracts of Gnotobiotic Mice by Engineered<i>Lactobacillus casei</i> (2006)

The gut microbiota is critical for maturation of the immune system. Recent evidence suggests that early establishment of lactobacilli in the intestinal microbiota, during neonatal colonization or by probiotic supplementation, could prevent the development of allergic disorders. Postnatal maturation of the gut immune system with allergen-producing lactobacilli colonizing the digestive tract could then affect the development of further allergic sensitization. In this paper, we describe construction of a recombinant Lactobacillus casei strain that can constitutively deliver bovine beta-lactoglobulin (BLG), a major cow's milk allergen, to the guts of gnotobiotic mice. The blg gene was inserted into the L. casei chromosome downstream of an endogenous promoter. BLG production was improved by fusing the propeptide LEISSTCDA (LEISS) to the BLG mature moiety. This led to a 10-fold increase in LEISS-BLG production compared to the production obtained without the propeptide and also led to enhanced secretion corresponding to 5% of the total production. After inoculation into germfree C3H/HeN mice, the genetic stability of the recombinant strain and in vivo BLG production were confirmed for at least 10 weeks. BLG stimulation of spleen cells from mice monoassociated with the BLG-producing lactobacilli induced secretion of the Th1 cytokine gamma interferon and, to a lesser extent, the Th2 cytokine interleukin-5. No BLG-specific immunoglobulin G1 (IgG1), IgG2a, or IgA was detected in sera or in fecal samples. These results suggest that gut colonization with allergen-producing lactobacilli could provide a useful model for studying the modulation of allergic disorders.
Blue phosphorescent nitrile containing C^C* cyclometalated NHC platinum(<scp>ii</scp>) complexes (2013)

Since C^C* cyclometalated Pt(II) complexes with N-heterocyclic carbene (NHC) ligands have been identified as potential emitter materials in organic light-emitting devices (OLEDs), very promising results regarding quantum yields, colour and stability have been presented. Herein, we report on four nitrile substituted complexes with a chelating NHC ligand (1-(4-cyanophenyl)-3-isopropyl-1H-benzo[d]imidazole or 4-(tert-butyl)-1-(4-cyanophenyl)-3-methyl-1H-imidazole) and a bidentate monoanionic auxiliary ligand (acetylacetone or dimesitoylmethane). The complexes have been fully characterized including extensive 2D NMR studies (COSY, HSQC, HMBC, NOESY, (195)Pt NMR), three of them also by solid-state structures. Photophysical measurements in amorphous PMMA films and pure emitter films at room temperature reveal the impact of the mesityl groups in the auxiliary ligand, which led to a significant increase of the quantum yield, while the decay lifetimes decreased. The electron withdrawing nitrile groups shift the emission towards blue colour coordinates.
Mechanism of the Reaction Catalyzed by Acetoacetate Decarboxylase. Importance of Lysine 116 in Determining the p<i>K</i><sub>a</sub> of Active-Site Lysine 115 (1996)

Acetoacetate decarboxylase from Clostridium acetobutylicum (AAD) catalyzes the decarboxylation of acetoacetate via a Schiff base intermediate [Hamilton, G. A., & Westheimer, F. H. (1959) J. Am. Chem. Soc. 81, 6332; Fridovich, I., & Westheimer F. H. (1962) J. Am. Chem. Soc. 84, 3208]. The pKa of the active-site lysine (Lys 115) is 6.0, 4.5 pKa units less than the pKa of lysine in solution [Kokesh, F. C., & Westheimer, F. H. (1971) J. Am. Chem. Soc. 93, 7270; Frey, P. A., Kokesh, F. C., & Westheimer, F. H. (1971) J. Am. Chem. Soc. 93, 7266; Schmidt, D. E., Jr., & Westheimer, F. H. (1971) Biochemistry 10, 1249]. Westheimer and co-workers hypothesized that the pKa of Lys 115 is decreased by its spatial proximity to the epsilon-ammonium group of Lys 116. We have investigated this proposal by studying site-directed mutants of Lys 115 and Lys 116. Two substitutions for Lys 115 (K115C and K115Q) were both catalytically inactive at pH 5.95, the pH optimum of wild type AAD, demonstrating the importance of this residue in catalysis. Activity could be restored to K115C by aminoethylation with 2-bromoethyl-ammonium bromide (2-BEAB). Substitutions for Lys 116 (K116C, K116N, and K116R) had reduced but significant activities at pH 5.95. The effects of Lys 116 on the pKa of Lys 115 in the mutant AADs were evaluated following imine formation with 5-nitrosalicylaldehyde and reduction with NaBH4. Whereas the pKa of Lys 115 in K116R is similar to that observed for wild type AAD, the pKaS of Lys 115 in K116C and K116N were elevated to > 9.2. Alkylation of Cys 116 in K116C with 2-BEAB resulted in both significant activation and restoration of the pKa of Lys 115 to 5.9. These data support Westheimer's hypothesis that the pKa of the Schiff base-forming Lys 115 is decreased by its spatial proximity to the epsilon-ammonium group of Lys 116.
Novel N-Substituted Amino-4-methylsulfanyl-2-pyridones and Deazapurine Analogues from Ketene Dithioacetals (1998)

A novel synthesis of N-substituted amino-4-methylsulfanyl-2-pyridones and deazapurine analogues via the reaction of ketene dithioacetals with substituted semi- and thio-semicarbazide derivatives is reported and the synthetic potential of the method is demonstrated.
Electrical Impedance Tomography: a new study method for neonatal Respiratory Distress Syndrome? (2011)

Treatment of cardiorespiratory system diseases is a procedure that usually demands data collection on terms of the anatomy and the operation of the organs that are under study. Electrical Impedance Tomography (EIT) is an alternative approach, in comparison to existing techniques. With EIT electrodes are placed in the perimeter of the human body and images of the estimated organ are reconstructed, using the measurement of its impendence (or resistance) distribution and determining its alteration through time, while at the same time the patient is not exposed to ionizing radiation. Its clinical use presupposes the correct placement of the electrodes over the perimeter of the human body, the rapid data collection and electrical safety. It is a low cost technique and it is implemented near the patient. It is able to determine the distribution of ventilation, blood supply, diffused or localized lung defects, but it can also estimate therapeutic interventions or alteration to assisted ventilation of the neonate. EIT was developed at the beginning of the 1980s, but it has only recently begun to be implemented on neonates, and especially in the study of their respiratory system function. The low rate of image analysis is considered to be a drawback, but it is offset by the potential offered for the estimation of lungs' function (both under normal and pathological conditions), since ventilation and resistance are two quite similar concepts. In this review the most important studies about EIT are mentioned as a method of estimating respiratory distress syndrome in neonates. In terms of the above mentioned development, it is supposed that this technique will offer a great amount of help to the doctor in his / her estimations of the cardiorespiratory system and to his / her selection of the best intervening strategies.
The Cognitive-Theoretic Model of the Universe: A New Kind of Reality Theory (2002)

Inasmuch as science is observational or perceptual in nature, the goal of providing a scientific model and mechanism for the evolution of complex systems ultimately requires a supporting theory of reality of which perception itself is the model (or theory-to-universe mapping). Where information is the abstract currency of perception, such a theory must incorporate the theory of information while extending the information concept to incorporate reflexive self-processing in order to achieve an intrinsic (self-contained) description of reality. This extension is associated with a limiting formulation of model theory identifying mental and physical reality, resulting in a reflexively self-generating, self-modeling theory of reality identical to its universe on the syntactic level. By the nature of its derivation, this theory, the Cognitive Theoretic Model of the Universe or CTMU, can be regarded as a supertautological reality-theoretic extension of logic. Uniting the theory of reality with an advanced form of computational language theory, the CTMU describes reality as a Self-Configuring Self-Processing Language or SCSPL, a reflexive intrinsic language characterized not only by self-reference and recursive self-definition, but full self-configuration and self- execution (reflexive read-write functionality). SCSPL reality embodies a dual-aspect monism consisting of infocognition, self-transducing information residing in self-recognizing SCSPL elements called syntactic operators. The CTMU identifies itself with the structure of these operators and thus with the distributive syntax of its self-modeling SCSPL universe, including the reflexive grammar by which the universe refines itself from unbound telesis or UBT, a primordial realm of infocognitive potential free of informational constraint. Under the guidance of a limiting (intrinsic) form of anthropic principle called the Telic Principle, SCSPL evolves by telic recursion, jointly configuring syntax and state while maximizing a generalized self- selection parameter and adjusting on the fly to freely-changing internal conditions. SCSPL relates space, time and object by means of conspansive duality and conspansion, an SCSPL-grammatical process featuring an alternation between dual phases of existence associated with design and actualization and related to the familiar wave-particle duality of quantum mechanics. By distributing the design phase of reality over the actualization phase, conspansive spacetime also provides a distributed mechanism for Intelligent Design, adjoining to the restrictive principle of natural selection a basic means of generating information and complexity. Addressing physical evolution on not only the biological but cosmic level, the CTMU addresses the most evident deficiencies and paradoxes associated with conventional discrete and continuum models of reality, including temporal directionality and accelerating cosmic expansion, while preserving virtually all of the major benefits of current scientific and mathematical paradigms.
Pharmacokinetics of Mycophenolate Mofetil in Patients with Autoimmune Diseases Compared Renal Transplant Recipients (2003)

Mycophenolate mofetil (MMF), being effectively used as immunosuppressant in transplant medicine, has recently attracted interest as therapeutic agent for autoimmune diseases (AID). For these patients, no pharmacokinetic (PK) data are available. This study is an investigation of single-dose concentration-time profiles of 1 g off MMF in 16 patients with AID, including 10 patients with ANCA-associated vasculitis and 6 patients with systemic lupus erythematosus, and compares them with profiles of 16 renal transplant recipients (RTX). Mycophenolic acid (MPA) blood levels were measured by both HPLC and EMIT, and MPA-glucuronide was determined by HPLC. In AID, mean MPA concentrations at 12 h were significantly higher compared with RTX (4.1 +/- 3.27 versus 1.8 +/- 1.15 mg/L; P = 0.018), whereas peak concentrations were lower (P = 0.017). However, mean MPA-AUC at 12 h as well as at 24 h were comparable between both groups. In contrast to RTX, there was an association in AID between MPA trough levels at 12 h and at 24 h with AUC(0-12) (P < 0.05 and P < 0.01). MPA trough concentrations at 24 h provided an estimation of AUC(0-24 h) in both patient groups (P < 0.001 and P < 0.01; AID and RTX, respectively). Compared with RTX, MPA-PK seems to be less affected in AID by renal function. Inter-individual variability of PK parameters was high in both groups. These data indicate that there are differences of MPA-PK between RTX and AID. The use of therapeutic drug monitoring in patients with AID appears to be clinically practicable and may be valuable to optimize individual immunosuppressive therapy.