gebhart/patrepeval huggingface dataset:
Identification of a Region within the ErbB2/HER2 Intracellular Domain That Is Necessary for Ligand-independent Association (2002)

Ligand-independent ErbB2 activation occurs principally by two distinct mechanisms: overexpression and mutation. Overexpression of ErbB2 at the plasma membrane drives receptor self-association in a concentration-dependent manner, which in turn leads to constitutive receptor activation. Subsets of human breast cancers contain a molecular alteration that leads to erbB2 gene amplification and subsequent protein overexpression. Although not recognized to occur in human cancers, mutation can also lead to increased ErbB2 association. A well characterized mutant of the rodent ortholog neu involves substitution of glutamate for valine within the transmembrane domain. In each case, a number of explanations have been proposed to explain the resulting ErbB2 activation. These include stabilization of receptor oligomers, release of negative constraints, and altered receptor conformations. Here we define a short amino acid segment comprising amino acids 966-968 in the intracellular domain that seemingly disrupts receptor-receptor association that is driven either by overexpression or mutation in the transmembrane region. Because of the hydrophobic nature of these amino acids (VVI), we propose that alteration of this segment likely results in a global conformational change in an area that has been proposed previously to be a dimerization motif for ErbB homomeric association.
Performance Analysis of Plasma Antenna with Different Shapes of Plasma Tube (2020)

Abstract This paper investigates analysis of a novel antenna design using plasma element instead of using metallic element as a conducting medium in transmit signal of radio frequency (RF). The main objective in this paper is to analyse the performance of plasma antenna using with different shapes of plasma tube. In this research, the simulation for four different designs (single tube, double tube, triple tube, and U-tube) with fixed gas (neon) and pressure (10 Torr) were conducted. Four different design tubes with constant length (160 mm) and diameter (10 mm), attached with coupling sleeve (copper) were used to analyze the electrical characteristic of electromagnetic wave propagation. Computer Simulation Technology (CST) was used to design the four custom made tubes and calculate the antenna parameters in terms of gain, return loss, directivity and radiation pattern. Plasma parameters were calculated by the CST software with frequency was set starting from 1 to 10 GHz for simulation based on the most effective range to get the best result. The results revealed that the triple tube has the highest gain of 3.247 dB with plasma frequency 1.22x10 9 rad/s and collision frequency 6.0985x10 8 collision/s. The three arrays on the triple tube gave the ability to transmit the input power into radiation in a specific magnitude is high. Although high gain obtained from the triple tube, U-tube shape gave the lowest Return Loss, S 11 value which is -15.706934 dB. The results show the ability of plasma antenna to transmit and receive a signal which is a basic part of an antenna.
Roll‐to‐Roll fabrication of large area functional organic materials (2012)

Abstract With the prospect of extremely fast manufacture of very low cost devices, organic electronics prepared by thin film processing techniques that are compatible with roll‐to‐roll (R2R) methods are presently receiving an increasing interest. Several technologies using organic thin films are at the point, where transfer from the laboratory to a more production‐oriented environment is within reach. In this review, we aim at giving an overview of some of the R2R‐compatible techniques that can be used in such a transfer, as well the current status of R2R application within some of the existing research fields such as organic photovoltaics, organic thin film transistors, light‐emitting diodes, polymer electrolyte membrane fuel cells, and electrochromic devices. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2012
Cervical lymph node metastasis in patients with submucosal carcinoma of the thoracic esophagus (2000)

Background and Objectives The effect of esophagectomy with three-field lymph node dissection for submucosal carcinoma of the thoracic esophagus remains controversial. The aim of this study was to evaluate the effect of esophagectomy with three-field lymph node dissection for submucosal carcinoma of the thoracic esophagus. Methods From January 1983 to December 1997, the records of 101 consecutive patients who underwent transthoracic esophagectomy with three-field lymph node dissection were retrospectively analyzed. Results The incidence of the operative complications was 70%. The 30-day and overall hospital mortality rates were 1.0% and 2.0%, respectively. The positive rate of histological cervical nodal metastasis was 17%. The 5-year survival rates for the patients with and those without cervical nodal metastasis were 55% and 71%, respectively. The difference between patients with and those without cervical nodal metastasis was not statistically significant. Cumulative 5-year survival rates for the patients with metastasis in the cervical, upper mediastinal, or abdominal lymph nodes were 55%, 65%, and 46%, respectively. There was no statistically significant difference between each survival. Conclusions Three-field lymph node dissection may be indicated for patients requiring esophagectomy for submucosal carcinoma of the thoracic esophagus because the frequency of cervical lymph node metastasis is not negligible and acceptable overall hospital mortality and favorable survival rates of patients with histologically positive cervical nodes can be achieved. J. Surg. Oncol. 2000:75:37–41. © 2000 Wiley-Liss, Inc.
Optimal Catastrophe Insurance with Multiple Catastrophes (1999)

This paper adopts a normative approach to catastrophe insurance. It addresses the question of how innovations in the design of insurance contracts could help resolve the capacity gap in the provision of insurance against natural catastrophes. It extends previous research with the same approach first by considering the case of "uncorrelated catastrophes", and second by combining the influence of catastrophes on claims amounts (severity risk) and on the probability of loss (frequency risk). We show that the menu of contracts proposed in previous research, where only one type of catastrophe is considered, is dominated by the menu of contracts proposed in this paper, taking into account the absence of correlation between catastrophes of different kinds.
Effective browsing and serendipitous discovery with an experience-infused browser (2012)

In the digital age, users can have perfect recall of their online experiences. In this paper, we explore how this recall can be leveraged during web browsing.
The Effect of Active-Layer Thickness and Back-Channel Conductivity on the Subthreshold Transfer Characteristics of Hf–In–Zn–O TFTs (2011)

The effect of active-layer thickness and back-channel conductivity on the subthreshold transfer characteristics of hafnium–indium–zinc–oxide (HIZO) thin-film transistors was studied. Experiments show that subthreshold humps in the transfer curves become more pronounced as the active-layer thickness increases, in the presence of a highly conductive back channel. With a highly conductive thin back channel, subthreshold humps were observed as the total active-layer thickness exceeded 80 nm. The above results can be interpreted as a consequence of a reduction in the effective gate field as the active thickness exceeds the “screening length”. The screening length of the HIZO layer is calculated to be approximately 78 nm, and accordingly, as the active thickness exceeds this value, subthreshold humps that are anticipated to originate from the back-channel conduction appear.
Pisa y la evaluación. Espejo o alimento: Notas al margen (2010)

Del 23 al 26 de noviembre, tuvo lugar en La Palma al Simposio Internacional PISA a examen -cambiar el conocimiento, cambiar las pruebas y cambiar las escuelas-. El autor, que participó en el mismo, describe y extrae conclusiones de la prolongada y fructífera conversación entre especialistas de la máxima solvencia, llegados de todo el mundo, de la mano de CESE -Comparative Education Society in Europe- y de su presidente, el palmero Miguel A. Pereyra.
NBS1 is required for macrophage homeostasis and functional activity in mice (2015)

Nijmegen breakage syndrome 1 (NBS1) is a component of the MRE11 complex, which is a sensor of DNA double-strand breaks and plays a crucial role in the DNA damage response. Because activated macrophages produce large amounts of reactive oxygen species (ROS) that can cause DNA lesions, we examined the role of NBS1 in macrophage functional activity. Proliferative and proinflammatory (interferon gamma [IFN-γ] and lipopolysaccharide [LPS]) stimuli led to increased NBS1 levels in macrophages. In mice expressing a hypomorphic allele of Nbs1, Nbs1(∆B/∆B), macrophage activation-induced ROS caused increased levels of DNA damage that were associated with defects in proliferation, delayed differentiation, and increased senescence. Furthermore, upon stimulation, Nbs1(∆B/∆B) macrophages exhibited increased expression of proinflammatory cytokines. In the in vivo 2,4-dinitrofluorobenzene model of inflammation, Nbs1(∆B/∆B) animals showed increased weight and ear thickness. By using the sterile inflammation by zymosan injection, we found that macrophage proliferation was drastically decreased in the peritoneal cavity of Nbs1(∆B/∆B) mice. Our findings show that NBS1 is crucial for macrophage function during normal aging. These results have implications for understanding the immune defects observed in patients with NBS and related disorders.
Determination of arsenic (1932)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of arsenicR. C. Wiley, J. P. Bewley, and R. IreyCite this: Ind. Eng. Chem. Anal. Ed. 1932, 4, 4, 396–397Publication Date (Print):October 1, 1932Publication History Published online1 May 2002Published inissue 1 October 1932https://pubs.acs.org/doi/10.1021/ac50080a025https://doi.org/10.1021/ac50080a025research-articleACS PublicationsRequest reuse permissionsArticle Views127Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Differential gene expression in white and brown preadipocytes (2001)

White (WAT) and brown (BAT) adipose tissue are tissues of energy storage and energy dissipation, respectively. Experimental evidence suggests that brown and white preadipocytes are differentially determined, but so far not much is known about the genetic control of this determination process. The aim of this study was to identify differentially expressed genes involved in brown and white preadipocyte development. Using representational difference analysis (cDNA RDA) and DNA microarray screening, we identified four genes with higher expression in white preadipocytes (three different complement factors and delta-6 fatty acid desaturase) and seven genes with higher expression levels in brown preadipocytes, of which three are structural genes implicated in cell adhesion and cytoskeleton organization (fibronectin, alpha-actinin-4, metargidin) and four that might function in gene transcription and protein synthesis (vigilin, necdin, snRNP polypeptide A, and a homolog to human hepatocellular carcinoma-associated protein). The expression profile of these genes was analyzed during preadipocyte differentiation, upon beta-adrenergic stimulation, and in WAT and BAT tissue in vivo compared with references genes such as peroxisome proliferator-activated receptor-gamma (PPARgamma), uncoupling protein 1 (UCP1), cytochrome c oxidase.
A short, enantioselective synthesis of the carbocyclic nucleoside carbovir (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA short, enantioselective synthesis of the carbocyclic nucleoside carbovirMichael R. Peel, Daniel D. Sternbach, and M. Ross JohnsonCite this: J. Org. Chem. 1991, 56, 16, 4990–4993Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://pubs.acs.org/doi/10.1021/jo00016a039https://doi.org/10.1021/jo00016a039research-articleACS PublicationsRequest reuse permissionsArticle Views404Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Shallow water multiple prediction and attenuation, case study on data from the Arabian Gulf (2002)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2002Shallow water multiple prediction and attenuation, case study on data from the Arabian GulfAuthors: Riaz Alá'iDirk Jacob VerschuurJock DrummondStan MorrisGerard HaugheyRiaz Alá'iAnadarko Petroleum Corporation, Dirk Jacob VerschuurDelft University of Technology, Jock DrummondAnadarko Petroleum Corporation, Stan MorrisAnadarko Petroleum Corporation, and Gerard HaugheyAnadarko Petroleum Corporationhttps://doi.org/10.1190/1.1817154 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1817154FiguresReferencesRelatedDetailsCited byRobust estimation of primaries by sparse inversion and Marchenko equation-based workflow for multiple suppression in the case of a shallow water layer and a complex overburden: A 2D case study in the Arabian GulfMyrna Staring, Marcin Dukalski, Mikhail Belonosov, Rolf H. Baardman, Jewoo Yoo, Rob F. Hegge, Roald van Borselen, and Kees Wapenaar5 February 2021 | GEOPHYSICS, Vol. 86, No. 2Integrated Geophysical Analyses of Shallow-Water Seismic Imaging With Scholte Wave Inversion: The Northern Adriatic Sea Case Study25 November 2020 | Frontiers in Earth Science, Vol. 8An alternative workflow for demultiple and PZ summation for two component OBC data - A 2D case studyRiaz Alai* and Shivaji Maitra5 August 2014Shallow water demultiple with seafloor reflection modeling using multichannel prediction operatorKunlun Yang and Barry Hung25 October 2012Model‐based water‐layer demultiplePing Wang, Hongzheng Jin, Sheng Xu, and Yu Zhang25 May 2012Surface multiple attenuation in seabeach‐shallow water, case study on data from the Bohai SeaBarry Hung, Kunlun Yang, Joe Zhou, Yonghe Guo, and Qing Long Xia21 October 2010 SEG Technical Program Expanded Abstracts 2002ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2002 Pages: 2478 publication data© 2002 Copyright © 2002 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 03 Jan 2005 CITATION INFORMATION Riaz Alá'i, Dirk Jacob Verschuur, Jock Drummond, Stan Morris, and Gerard Haughey, (2002), "Shallow water multiple prediction and attenuation, case study on data from the Arabian Gulf," SEG Technical Program Expanded Abstracts : 2229-2232. https://doi.org/10.1190/1.1817154 Plain-Language Summary PDF DownloadLoading ...
3D Parameters and New Filtration Techniques (2006)

For a long time surface metrology has been based upon contact measurement using 2D profilometers. Over the past twenty years the appearance of 3D profilometers and non-contact gauges has created a need for the standardization and formalization of the analysis of 3D surface texture. This paper presents the current status of the standardization process and includes a short description of the tools and parameters that will become available to users when work on the definition of the new standards, which is being carried out by working groups WG15 and WG16 of ISO technical committee TC213, has been completed.
Wavelength-tuning-free 10-Gb/s operation of a silicon-integrated resonantly-enhanced modulator and single-mode laser (2012)

A modulator with an enhanced efficiency by cascaded microring resonators (MRRs), and a single-mode laser with a wavelength determined by a MRR wavelength filter were integrated on a Si chip to demonstrate for the first time wavelength-tuning-free 10-Gb/s modulation over a wide range of temperature.
TRPM2 Channel Regulates Endothelial Barrier Function (2009)

Oxidative [Au1]stress, through the production of oxygen metabolites such as hydrogen peroxide[Au2] (H(2)O(2)), increases vascular endothelial permeability and plays a crucial role in several lung diseases. The transient receptor potential (melastatin) 2 (TRPM2) is an oxidant-sensitive, nonselective cation channel that is widely expressed in mammalian tissues, including the vascular endothelium. We have demonstrated the involvement of TRPM2 in mediating oxidant-induced calcium entry and endothelial hyperpermeability in cultured pulmonary artery endothelial cells. Here, we provide evidence that neutrophil activation-dependent increase in endothelial permeability and neutrophil extravasation requires TRPM2 in cultured endothelial cells. In addition, protein kinase Calpha (PKCalpha) that rapidly colocalizes with the short (nonconducting) TRPM2 isoform after exposure to hydrogen peroxide positively regulates calcium entry through the functional TRPM2 channel. Thus, increase in lung microvessel permeability and neutrophil sequestration depends on the activation of endothelial TRPM2 by neutrophilic oxidants and on PKCalpha regulation of TRPM2 channel activity. Manipulating TRPM2 function in the endothelium may represent a novel strategy aimed to prevent oxidative stress-related vascular dysfunction.
The impact of 'terminator' technology (2001)

Genetic use-restriction technologies enable the developers of transgenic plants or animals to protect their variety or breed from unauthorized use in a biological way. The use of 'terminator technology' can have different impacts on farmers and breeders. If the technology is effective, it impacts on agrobiodiversity and environment. This article focuses on the technology and its environmental effects.
Optical nanosensors—an enabling technology for intracellular measurements (2003)

Optical nanosensors have been designed to utilise the sensitivity of fluorescence for making quantitative measurements in the intracellular environment, using devices that are small enough to be inserted into living cells with a minimum of physical perturbation. Advantages over widely used fluorescence dye based methods are observed because the nanosensor matrix imparts two key benefits; (1) protection of the sensing component from interfering species within the intracellular environment and (2) protection of the intracellular environment from any toxic effects of the sensing component. This Highlight article discusses the recent developments in nanosensor technology and investigates the use of more complex sensing schemes that will expand the range of analytes that can be detected and quantified.
Intracellular Na<sup>+</sup> measurements using sodium green tetraacetate with flow cytometry (1995)

Intracellular sodium concentration ([Na+]i) can be measured using SBFI with image analysis or spectrofluorometry. However, SBFI cannot be used with most flow cytometry systems, due to its requirement for dual excitation in the UV range. Recently a new sodium indicator, Sodium Green, was developed which can be used with flow cytometry to measure [Na+]i. Adequate staining of cells with Sodium Green is dependent upon both dye and cell concentration, time and temperature of loading, use of the non-ionic detergent Pluronic, and the cell line used. Both Sodium Green and SBFI give similar calibration curves using the ionophore gramicidin. Sodium Green has a small pH dependence, but this should not affect most applications. Since a fluorescence ratio technique cannot be used with Sodium Green, we used a ratio of dye fluorescence to forward angle light scatter to normalize for cell size variations in the population. The basal [Na+]i obtained using the Sodium Green technique in CHO ISI cells was 19 mM, in reasonable agreement with previous studies using SBFI in other cells.
<title>Transform domain image restoration methods: review, comparison, and interpretation</title> (2001)

Two families of transform domain signal restoration (denoising and deblurring) and enhancement methods well suited to processing non-stationary signals are reviewed and comprehensively compared in their different modifications in terms of their signal restoration capability and computational complexity: sliding window transform domain (SWTD) filters and wavelet (WL) based algorithms. SWTD filters work in sliding window in the domain of an orthogonal transform and, in each position of the window, nonlinearly transform window transform coefficients to generate an estimate of the central pixel of the window. As a transform, DCT has been found to be one of the most efficient in most applications. WL methods act globally and apply element-wise nonlinear transformation similar to those used in SWTD methods to the wavelet transform coefficients to generate an estimate of the output signal. The paper provides results of extensive experimental comparisons of image restoration capabilities of the methods and demonstrates that they can naturally be interpreted in a unified way as different implementations of signal sub-band decomposition with uniform (in SWTD filters) or logarithmic (for WL-methods) arrangement of signal sub-bands and element-wise processing decomposed components. As a bridge, a hybrid wavelet/sliding window processing that combines advantages of both methods is described.