gebhart/patrepeval huggingface dataset:
Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator. (1989)

Reocclusion of the coronary artery occurs after thrombolytic therapy of acute myocardial infarction despite routine use of the anticoagulant heparin. However, heparin is inhibited by platelet activation, which is greatly enhanced in this setting. Consequently, it is unclear whether thrombin induces acute reocclusion. To address this possibility, we examined the effect of argatroban [MCI9038, (2R,4R)-4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetrahydro-8- quinolinesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid], a specific thrombin inhibitor, on the response to tissue-type plasminogen activator in a closed-chest canine model of coronary thrombosis. MCI9038 prolonged the thrombin time and shortened the time to reperfusion (28 +/- 2 min vs. 59 +/- 7 min in controls; mean +/- SEM, n = 5, P less than 0.01). At the highest dose, 2.5 mg/kg per hr, complete reocclusion was prevented in four of the five experimental animals, whereas reocclusion occurred in all five controls. However, reperfusion was complicated by cycles of decrease flow, which were abolished by the thromboxane A2 antagonist, GR32191. GR32191 at 1 mg/kg combined with MCI9038 at 0.5 mg/kg per hr prevented reocclusion, whereas, at these doses, either drug alone was without effect. In addition, thromboxane A2 biosynthesis, determined as excretion of its metabolite 2,3-dinor-thromboxane B2, was increased after reperfusion at all doses of MCI9038. These data demonstrate that thrombin impairs thrombolysis induced by tissue-type plasminogen activator in vivo and induces acute reocclusion. Furthermore, the response to thrombin inhibition may be impaired by continued formation of thromboxane A2.
Hypertensive disorders in pregnancy: screening by uterine artery Doppler imaging and blood pressure at 11–13 weeks (2009)

Effective screening for hypertensive disorders in pregnancy is provided by a combination of maternal history, uterine artery Doppler imaging and blood pressure at 11-13 weeks.
Purification,Characterization of Raventoxin-VI from the Venom of the Spider Macrothele raveni (2003)

A novel neurotoxin named RaventoxinVI is purified from the venom of the spider Macrothele raveni by ion exchange chromatography and reverse phase high performance liquid chromatography.The molecular weight of RaventoxinVI is (5 371.6±0.5) Da,identified by MALDITOF mass spectrometry,which is in good agreement with the complete amino acid sequence of NH2NIIKGRVVKLCGGCAQKCCDREPRCDPCRTCVENVGTGGGYLSSNKKNCGSCOOH determined by automatic Edman degradation.RaventoxinVI is a novel neurotoxin which can paralyze rat after intracerebroventricular injection and block the neuromuscular transmission of isolated rat phrenic nerve diaphragm preparation. The 51residues peptide,which contained 8 Cys and formed four disulfide bonds,shows no homology with other spider toxins.
Social Identity and Group Lending (2004)

'The success of joint liability programs depends on nature and composition of borrowing groups. Group formation is a costly process and in our model these costs vary with the social identity of group partners. We show that risk heterogeneity in a borrowing group may arise due to the social identity of the agents. The presence of caste and gender bias may not resolve the adverse selection and moral hazard problems created by information asymmetry between the borrowers and the lender. We also find that with costly group formation and state verification, individual liability lending may be better than joint liability lending. Thus ignoring social identity and group formation costs can lead to the failure of a joint liability program. Finally, the paper also suggests that targeting different social groups requires the use of a menu of joint liability costs.' (author's abstract)
The Moist Available Energy of a Conditionally Unstable Atmosphere. Part II: Further Analysis of GATE Data (1994)

The generalized convective available potential energy (GCAPE) observed during GATE has been analyzed using the Lagrangian algorithm of Lorenz, as modified by Randall and Wang. The effects of ice are included and are discussed in an Appendix. A high positive correlation is found between the rate of GCAPE production by large-scale processes and the observed precipitation rate, and a negative correlation between the GCAPE itself and the precipitation rate. The observed time rate of change of the GCAPE is much smaller than the rate of GCAPE production by large-scale processes.
Overexpression of corticotropin‐releasing hormone in transgenic mice and chronic stress‐like autonomic and physiological alterations (2002)

To gain a greater insight into the relationship between hyperactivity of the corticotropin-releasing hormone (CRH) system and autonomic and physiological changes associated with chronic stress, we developed a transgenic mouse model of central CRH overproduction. The extent of central and peripheral CRH overexpression, and the amount of bioactive CRH in the hypothalamus were determined in two lines of CRH-overexpressing (CRH-OE) mice. Furthermore, 24 h patterns of body temperature, heart rate, and activity were assessed using radiotelemetry, as well as cumulative water and food consumption and body weight gain over a 7-day period. CRH-OE mice showed increased amounts of CRH peptide and mRNA only in the central nervous system. Despite the presence of the same CRH transgene in their genome, only in one of the two established lines of CRH-OE mice (line 2122, but not 2123) was overexpression of CRH associated with increased levels of bioactive CRH in the hypothalamus, increased body temperature and heart rate (predominantly during the light (inactive) phase of the diurnal cycle), decreased heart rate variability during the dark (active) phase, and increased food and water consumption, when compared with littermate wildtype mice. Because line 2122 of the CRH transgenic mice showed chronic stress-like neuroendocrine and autonomic changes, these mice appear to represent a valid animal model for chronic stress and might be valuable in the research on the consequences of CRH excess in situations of chronic stress.
DensePhysNet: Learning Dense Physical Object Representations via Multi-step Dynamic Interactions (2019)

We study the problem of learning physical object representations for robot manipulation. Understanding object physics is critical for successful object manipulation, but also challenging because physical object properties can rarely be inferred from the object's static appearance. In this paper, we propose DensePhysNet, a system that actively executes a sequence of dynamic interactions (e.g., sliding and colliding), and uses a deep predictive model over its visual observations to learn dense, pixel-wise representations that reflect the physical properties of observed objects. Our experiments in both simulation and real settings demonstrate that the learned representations carry rich physical information, and can directly be used to decode physical object properties such as friction and mass. The use of dense representation enables DensePhysNet to generalize well to novel scenes with more objects than in training. With knowledge of object physics, the learned representation also leads to more accurate and efficient manipulation in downstream tasks than the state-of-the-art.
GeV PARTONS AND TeV HEXONS FROM A TOPOLOGICAL VIEWPOINT (1984)

An elementary TeV topological hadron supermultiplet breaks into GeV-scale mesons, baryons and baryoniums and TeV-scale hexons (extremely-heavy bosons corresponding to six topological constituents). Phenomena on the GeV scale are describable by parton graphs which give meaning to constituent quarks of QCD type. Hexons are responsible - through mixing - for electroweak-boson masses, may be responsible for cosmic-ray Centauro events, and promise novel TeV accelerator phenomena. 25 references.
Design and applications of a versatile HF radar calibration target in low Earth orbit (2008)

High frequency (HF) radars are used to detect ionospheric irregularities, meteor trails, and moving targets. The Precision Expandable Radar Calibration Sphere (PERCS) is a simple radar target in space to help determine the operational parameters of ground HF radars. PERCS will have a known radar cross section that is independent of observation direction within 0.5 dB. The PERCS satellite can be launched in a stowed configuration that has about 1 m in diameter. After launch, the PERCS will expand to a diameter of almost 10 m. Upon expansion, a stable wire frame is formed to act as a radar scatter target in the form of a polyhedral sphere. The simplest version of the sphere has 60 vertices (V60) that are joined to 90 rigid segments. Each segment is hinged so that the PERCS can be folded into a compact package for launch. Analysis of the V60 wire frame with a 10 m diameter shows that the radar cross section (RCS) is nearly independent of viewing angle up to 30 MHz. Another design with 240 vertices produces even better performance. Radar systems will be calibrated using the radar echo data and the precise knowledge of the target RCS, position, and velocity. The PERCS can reflect radar signals from natural targets such as field aligned and current driven irregularities not presently accessible from ground‐based radars. The wire frame structure has several advantages over a metalized spheroid “balloon” with (1) much less drag, (2) larger radar cross section, and (3) lower fabrication cost.
A Compact and Broadband Ka-band Asymmetrical GaAs Doherty Power Amplifier MMIC for 5G Communications (2018)

In this paper, we present a compact and broadband Ka-band asymmetrical Doherty power amplifier (DPA) MMIC in a 0.15-μm enhancement mode (E-mode) GaAs pHEMT process. The offset line behind the main power amplifier is removed without degrading the back-off efficiency by choosing an appropriate output matching network and employing a design method based on load-pull data, which results in a compact chip size of 2.1 mm x 1.7 mm, and a broad bandwidth (BW) of 2.8 GHz, simultaneously. Experimental results demonstrate that the DPA achieves a saturation output power of 26.3 dBm, with a power added efficiency (PAE) of 35% at saturation and 28% at 7 dB power backoff (PBO) at the frequency of 31.1 GHz. The DPA also achieves a saturation output power of 25.7 dBm-26.8 dBm, a peak PAE of 31%-38%, and a PAE at 7 dB PBO of 21%-30% in the frequency range of 29 GHz to 31.8 GHz.
Essentiality of boron for healthy bones and joints. (1994)

Since 1963, evidence has accumulated that suggests boron is a safe and effective treatment for some forms of arthritis. The initial evidence was that boron supplementation alleviated arthritic pain and discomfort of the author. This was followed by findings from numerous other observations epidemiologic and controlled animal and human experiments. These findings included a) analytical evidence of lower boron concentrations in femur heads, bones, and synovial fluid from people with arthritis than from those without this disorder; b) observation evidence that bones of patients using boron supplements are much harder to cut than those of patients not using supplements; c) epidemiologic evidence that in areas of the world where boron intakes usually are 1.0 mg or less/day the estimated incidence of arthritis ranges from 20 to 70%, whereas in areas of the world where boron intakes are usually 3 to 10 mg, the estimated incidence of arthritis ranges from 0 to 10%; d) experimental evidence that rats with induced arthritis benefit from orally or intraperitoneally administered boron; e) experimental evidence from a double-blind placebo-boron supplementation trial with 20 subjects with osteoarthritis. A significant favorable response to a 6 mg boron/day supplement was obtained; 50% of subjects receiving the supplement improved compared to only 10% receiving the placebo. The preceding data indicate that boron is an essential nutrient for healthy bones and joints, and that further research into the use of boron for the treatment or prevention of arthritis is warranted.
A Promising Therapeutic Approach for Treatment of Posterior Uveitis: Recombinant T Cell Receptor Ligand Protects Lewis Rats from Acute and Recurrent Experimental Autoimmune Uveitis (2010)

Our studies demonstrate a successful treatment of acute and recurrent EAU with RTL220, which effectively suppressed the recurrence of inflammation and reversed clinical and histological EAU by altering cytokine and chemokine expression. These findings strongly support a possible clinical application of this novel class of peptide/MHC class II drugs for patients with autoimmune uveitis.
Optical heterodyne interferometer with radiofrequency phase reference (1976)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. J. Lavan, W. K. Cadwallender, T. F. DeYoung, and G. E. Van Damme, "Optical heterodyne interferometer with radiofrequency phase reference," Appl. Opt. 15, 2627-2628 (1976) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Cross-Validatory Selection of Binary Variables in Differential Diagnosis (1980)

A. Mabbett, M. Stone, J. Washbrook, Cross-Validatory Selection of Binary Variables in Differential Diagnosis, Journal of the Royal Statistical Society. Series C (Applied Statistics), Vol. 29, No. 2 (1980), pp. 198-204
Fusing image data with location and orientation sensor data streams for consumer video applications (2010)

We discuss the problem of fusing the information in a video stream with synchronized streams of location and orientation data obtained from sensors attached to the video camera. We are interested in using this information for the reconstruction of camera trajectory and observed scenery from consumer videos with the objective of visualizing those in a 3D virtual environment. We review existing literature and applications and suggest application scenarios for personal video. We discuss the issues that distinguish the personal video application from similar applications and present outlines of algorithms for several consumer video application scenarios.
Electronic structure of the layer compounds GaSe and InSe in a tight-binding approach (2002)

The three-dimensional band structure of the III-VI layer compounds GaSe and InSe has been investigated in the tight-binding approach. The pseudo-Hamiltonian matrix elements in the ${\mathrm{sp}}^{3}{s}^{*}$ basis are fit in order to reproduce the nonlocal pseudopotential band structure, in the framework of constrained optimization techniques using the conjugate gradient method. The results are in good agreement with the optical and photoemission experimental data. The scaling laws appropriate to the covalent bonding are violated by a fraction of eV only, which suggests that the interlayer interactions are not solely of the van der Waals type.
Rapid, automated, parallel quantitative immunoassays using highly integrated microfluidics and AlphaLISA (2015)

Immunoassays represent one of the most popular analytical methods for detection and quantification of biomolecules. However, conventional immunoassays such as ELISA and flow cytometry, even though providing high sensitivity and specificity and multiplexing capability, can be labor-intensive and prone to human error, making them unsuitable for standardized clinical diagnoses. Using a commercialized no-wash, homogeneous immunoassay technology ('AlphaLISA') in conjunction with integrated microfluidics, herein we developed a microfluidic immunoassay chip capable of rapid, automated, parallel immunoassays of microliter quantities of samples. Operation of the microfluidic immunoassay chip entailed rapid mixing and conjugation of AlphaLISA components with target analytes before quantitative imaging for analyte detections in up to eight samples simultaneously. Aspects such as fluid handling and operation, surface passivation, imaging uniformity, and detection sensitivity of the microfluidic immunoassay chip using AlphaLISA were investigated. The microfluidic immunoassay chip could detect one target analyte simultaneously for up to eight samples in 45 min with a limit of detection down to 10 pg mL(-1). The microfluidic immunoassay chip was further utilized for functional immunophenotyping to examine cytokine secretion from human immune cells stimulated ex vivo. Together, the microfluidic immunoassay chip provides a promising high-throughput, high-content platform for rapid, automated, parallel quantitative immunosensing applications.
Safe and efficient active network programming (2002)

Active networks are aimed at incorporating programmability into the network to achieve extensibility. One approach to obtaining extensibility is to download router programs into network nodes. This programmability is critical to allow multipoint distributed systems to adapt to network conditions and individual clients' needs. Although promising, this approach raises critical issues such as safety to achieve reliability despite the complexity of a distributed system, security to protect shared resources, and efficiency to maximize usage of bandwidth. This paper proposes the use of a domain-specific language, PLAN-P, to address all of the above issues. To address safety and security, we give examples of properties of PLAN-P programs that can be automatically checked due to the use of a restricted language. For efficiency, we show that an automatically generated run-time compiler for PLAN-P produces code which outperforms an equivalent compiled Java program. Additionally, we present performance results on a real application (learning bridge) where we obtain 100% of the maximum possible throughput.
An Evaluation of a Self-Management Program for Adults with Asthma (1997)

The purpose of this study was to evaluate the impact of a self-management program for adults with moderate to severe asthma on compliance with inhaled, prescribed, nonemergency medications; asthma symptoms; and airway obstruction. In this controlled experimental study, 55 subjects from a rural community were randomized to one of two groups. Self-efficacy theory served as the framework for this study. Primary measures included the Metered Dose Inhaler (MDI) Chronolog, a journal of daily asthma concerns, and a peak-flow meter to appraise airway obstruction. Secondary measures included the Asthma Self-Management Assessment Tool (ASMAT) and the Self-Efficacy for Asthma Management Scale (SEAMS). These measures were completed pre- and post-intervention. Data analysis using descriptive and inferential statistics revealed that subjects receiving the self-management program increased compliance with inhaled medications (U = 271, p = .043).
A 5mm<sup>2</sup> 40nm LP CMOS 0.1-to-3GHz multistandard transceiver (2010)

The trend in wireless communication where terminals give their users ubiquitous access to a multitude of services drives the development of Software-Defined Radio (SDR) in deeply scaled CMOS. This is enhanced with the advent of LTE, a standard that is inherently so flexible that an SDR is its most economical implementation. This work presents an answer to that need with the development of a complete transceiver with RF, baseband and data converter circuits in 40nm LP CMOS.
Sequential Differentiation of Embryonic Stem Cells into Neural Epithelial-Like Stem Cells and Oligodendrocyte Progenitor Cells (2016)

We developed a precise and reliable strategy for sequential differentiation to capture NESCs and OPCs derived from ESCs, thus providing unlimited cell source for cell transplantation and drug screening towards CNS repair.
Seismic anisotropy in sedimentary rocks, part 1: A single-plug laboratory method (2002)

Abstract A single-plug method for measuring seismic velocities and transverse isotropy in rocks has been rigorously validated and laboratory tested. The method requires only one sample to measure the velocities needed to derive the five independent elastic constants for transversely isotropic materials. In this method, piezoelectric transducers are fitted to the top, bottom, and sides of the cylindrical sample. Laboratory velocity and anisotropy can be measured as functions of pressure, temperature, fluid saturation, and fluid displacement. Because this method uses a horizontal core plug that has much higher permeability than a vertical core plug, it is especially suitable for low-permeability shale measurements. It reduces the sample preparation and velocity measurement time by more than two-thirds.
<i>neu/ERBB2</i> Cooperates with <i>p53-172H</i> during Mammary Tumorigenesis in Transgenic Mice (1997)

Thirty percent of human breast cancers have amplification of ERBB2, often in conjunction with mutations in p53. The most common p53 mutation in human breast cancers is an Arg-to-His mutation at codon 175, an allele that functions in a dominant oncogenic manner in tumorigenesis assays and is thus distinct from loss of p53. Transgenic mice expressing mouse mammary tumor virus-driven neu transgene (MMTV-neu) develop clonal mammary tumors with a latency of 234 days, suggesting that other events are necessary for tumor development. We have examined the role of mutations in p53 in tumor development in these mice. We have found that 37% of tumors arising in these mice have a missense mutations in p53. We have directly tested for cooperativity between neu and mutant p53 in mammary tumorigenesis by creating bitransgenic mice carrying MMTV-neu and 172Arg-to-His p53 mutant (p53-172H). In these bitransgenic mice, tumor latency is shortened to 154 days, indicating strong cooperativity. None of the nontransgenic mice or the p53-172H transgenic mice developed tumors within this time period. Tumors arising in the p53-172H/neu bitransgenic mice were anaplastic and aneuploid and exhibited increased apoptosis, in distinction to tumors arising in p53-null mice, in which apoptosis is diminished. Further experiments address potential mechanisms of cooperativity between the two transgenes. In these bitransgenic mice, we have recapitulated two common genetic lesions that occur in human breast cancer and have shown that p53 mutation is an important cooperating event in neu-mediated oncogenesis.
Mutual coupling between microstrip antennas (1982)

A theoretical study of mutual coupling between microstrip antennas is presented. The cavity method is used, and from the equivalence theorem application the problem is reduced to interaction of two magnetic loops. The mutual impedance is then calculated from the reaction theorem. Theoretical results and measurements are in good agreement.
Predictors of false-positive stroke thrombectomy transfers (2017)

Clinical scales appear to overdiagnose LVO and may be responsible for the majority of our stroke code transfers not undergoing thrombectomy. Primary stroke centres therefore have reason to develop the capability to rapidly acquire and interpret a CTA in patients with suspected LVO prior to transfer. Such efforts may reduce the costs associated with unnecessary thrombectomy transfers.