gebhart/patrepeval huggingface dataset:
Simple Proportional Fairness Scheduling for OFDMA Frame-Based Wireless Systems (2008)

We propose a packet scheduling scheme called OFDMA frame-based proportional fairness (OFPF) for a frame- based OFDMA wireless system. OFPF aims to maximize system throughput as well as maintain fairness between users. We define the scheduling resources as slots of fixed duration per OFDMA subchannel. Furthermore, we assume a realistic traffic pattern in which the user queues are not always backlogged. We suggest a simple method to update the average data rate in the PF ratio. In addition, we introduce an uncomplicated approach to schedule user data using matrix-based calculation. The simulation shows that our scheme improves performance in terms of throughput, delay, and fairness.
The pure anti-androgen bicalutamide inhibits cyclin A expression both in androgen-dependent and -independent cell lines (2010)

We investigated the effects of testosterone and the pure anti-androgen, bicalutamide, on DNA synthesis and cell cycle in androgen-sensitive or -insensitive human and mouse cell lines by 3H-thymidine incorporation, flow cytometry, RT-PCR and Western blotting. In androgen-dependent mouse SC-3 cells, testosterone induced DNA synthesis, shift of cell cycle distribution from G0/G1 to S/G2/M and expression of cyclin A. The induction was preceded by that of fibroblast growth factor 8 (FGF-8), and completely blocked by monoclonal antibody to FGF-8. Dihydrotestosterone (DHT) induced cyclin A expression in androgen-sensitive human prostate cancer cells, but not in androgen-independent cell lines. Bicalutamide almost completely inhibited these androgen-dependent effects both in LNCaP and SC-3 cells, but had no or limited effect on androgen-independent or FGF-8-induced DNA synthesis, and FGF-8 induced cyclin A expression. Interestingly, bicalutamide inhibited both DNA synthesis and the cyclin A expression in androgen-independent human cell lines in serum-free condition. A MEK1/2 inhibitor U0126 blocked both androgen- and rFGF-8-induced DNA synthesis. Overall, bicalutamide inhibits the cyclin A expression possibly by inhibiting FGF-8 mRNA expression and FGF-8 protein secretion but not by inhibiting FGF receptor (FGFR) signalling in androgen-dependent cell lines, and by other mechanisms in androgen-independent cell lines. The results suggest that combination with compounds such as FGFR signalling inhibitors may provide additional benefits to anti-androgens. It is also suggested that cyclin A could be a sensitive marker for androgen-induced cancer growth and for the growth inhibitory effects of anti-androgen.
SyncTS: Automatic Synchronization of Speech and Text Documents (2011)

In this paper, we present an automatic approach for aligning speech signals to corresponding text documents. For this sake, we propose to first use text-to-speech synthesis (TTS) to obtain a speech signal from the textual representation. Subsequently, both speech signals are transformed to sequences of audio features which are then time-aligned using a variant of greedy dynamic time-warping (DTW). The proposed approach is both efficient (with linear running time), computationally simple, and does not rely on a prior training phase as it is necessary when using HMM-based approaches. It benefits from the combination of a) a novel type of speech feature, being correlated to the phonetic progression of speech, b) a greedy left-to-right variant of DTW, and c) the TTS-based approach for creating a feature representation from the input text documents. The feasibility of the proposed method is demonstrated in several experiments. 1.
Does residual cement around implant‐supported restorations cause peri‐implant disease? A retrospective case analysis (2012)

Implants with cement remnants in patients with history of periodontitis may be more likely to develop peri-implantitis, compared with patients without history of periodontal infection.
Static analysis of millimeter wave transmission lines micromachined in silicon substrate (2002)

Several millimeter wave transmission lines fabricated on silicon substrate are investigated numerically. The structures of this kind of transmission lines consist of metal strips evaporated on oxynitride membrane with a silicon substrate as the mechanical supporting materials. The characteristic impedances for single strip transmission lines and coupled transmission lines are obtained as functions of the physical parameters by the point matching method.
Desarrollo institucional de la Comunidad Andina (2004)

"Desde la firma del Acuerdo de Cartagena se acordó dotarlo de instituciones para dirigir y orientar la integración, las cuales han sido objeto de distintas modificaciones. El trabajo busca revisar estos cambios institucionales desde 1969 hasta la actualidad en que el Acuerdo se ha convertido en Comunidad Andina(CAN); encontrar explicaciones a estos cambios a la luz de la realidad económica y política que ha venido experimentando la región a fin de indagar si los mismos se deben a presiones derivadas de las modificaciones en esa realidad, y discutir sobre la importancia de la institucionalidad en la integración regional. Se intentará comparar las instituciones de la CAN con las de la Unión Europea para destacar semejanzas y contrastes así como su funcionalidad. La discusión final será producto del cotejo de la evaluación de las instituciones de la integración andina con el enfoque teórico que señala que para que una experiencia de integración tenga éxito, los Estados y las instituciones deben ser fuertes a fin de orientar y dirigir ese proceso."
Status of the Novosibirsk phi-factory project (2002)

An electron-positron colliding beam facility is described. The facility comprises a 4*7 GeV B-factory with a luminosity of 5*10/sup 33/ cm/sup -2/ s/sup -1/; a phi -factory with a luminosity of over 10/sup 33/ cm/sup -2/ s/sup -1/; an injector consisting of a linear accelerator and a cooling storage ring for providing the factories with intense electron and positron beams. After investigating the relevant problems of accelerator physics and running the first cycle of experiments with the CMD-3 detector, the second stage of the project will come into being. It will be devoted to increasing the luminosity. To attain this, the magnetic structure and the storage ring design provide for a three-bunched beam regime applying electrostatic beam separation at the side interaction points.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
In vivo efficacy of the antimicrobial peptide ranalexin in combination with the endopeptidase lysostaphin against wound and systemic meticillin-resistant Staphylococcus aureus (MRSA) infections (2010)

New treatments are urgently required for infections caused by meticillin-resistant Staphylococcus aureus (MRSA) as these strains are often resistant to multiple conventional antibiotics. Earlier studies showed that ranalexin, an antimicrobial peptide (AMP), in combination with lysostaphin, an antistaphylococcal endopeptidase, synergistically inhibits the growth of MRSA, meaning that it deserved consideration as a new anti-S. aureus therapy. Using haemolysis and Vero cell viability assays, ranalexin with lysostaphin is proven to be non-toxic at antibacterial concentrations. In human serum, ranalexin with lysostaphin is significantly more effective against MRSA than treatment with either component alone. In a rabbit model of wound infection, ranalexin with lysostaphin reduced MRSA in the wound by ca. 3.5log(10) colony-forming units (CFU) compared with the untreated control. The combination is significantly more effective than treatment with ranalexin or lysostaphin alone. In a mouse model of systemic infection, ranalexin with lysostaphin reduced MRSA kidney burden by ca. 1log(10)CFU/g compared with untreated controls or treatment with ranalexin or lysostaphin alone. Importantly, the combination is synergistically bactericidal against various S. aureus isolates in vitro, including those with reduced susceptibility to lysostaphin or vancomycin. Ranalexin and lysostaphin could be incorporated in wound dressings for the prevention and treatment of topical S. aureus infections. That AMPs can enhance the antibacterial effectiveness of lysostaphin in vivo highlights a new avenue of research in the fight against drug-resistant staphylococci.
Coordinate developmental control of the meiotic cell cycle and spermatid differentiation in <i>Drosophila</i> males (1996)

Wild-type function of four Drosophila genes, spermatocyte arrest, cannonball, always early and meiosis I arrest, is required both for cell-cycle progression through the G2/M transition of meiosis I in males and for onset of spermatid differentiation. In males mutant for any one of these meiotic arrest genes, mature primary spermatocytes with partially condensed chromosomes accumulate and postmeiotic cells are lacking. The arrest in cell-cycle progression occurs prior to degradation of cyclin A protein. The block in spermatogenesis in these mutants is not simply a secondary consequence of meiotic cell-cycle arrest, as spermatid differentiation proceeds in males mutant for the cell cycle activating phosphatase twine. Instead, the arrest of both meiosis and spermiogenesis suggests a control point that may serve to coordinate the male meiotic cell cycle with the spermatid differentiation program. The phenotype of the Drosophila meiotic arrest mutants is strikingly similar to the histopathological features of meiosis I maturation arrest infertility in human males, suggesting that the control point may be conserved from flies to man.
The usefulness of liver stiffness measurement using FibroScan in chronic hepatitis C in South Korea: A multicenter, prospective study (2010)

Our data suggest that LSM can accurately assess liver fibrosis in patients with CHC and be applied in South Korea.
Intermediate Trapping on a Mutant Retaining α-Galactosyltransferase Identifies an Unexpected Aspartate Residue (2004)

Lipopolysaccharyl-alpha-1,4-galactosyltransferase C (LgtC), a glycosyltransferase family 8 alpha-1,4-galactosyltransferase from Neisseria meningitidis, catalyzes the transfer of galactose from UDP galactose to terminal lactose-containing acceptor sugars with net retention of anomeric configuration. To investigate the potential role of discrete nucleophilic catalysis suggested by the double displacement mechanism generally proposed for retaining glycosyltransferases, the side chain amide of Gln-189, which is suitably positioned to act as the catalytic nucleophile of LgtC, was substituted with the more nucleophilic carboxylate-containing side chain of glutamate in the hope of accumulating a glycosyl-enzyme intermediate. The resulting mutant was subjected to kinetic, mass spectrometric, and x-ray crystallographic analysis. Although the K(m) for UDP-galactose is not significantly altered, the k(cat) was reduced to 3% that of the wild type enzyme. Electrospray mass spectrometric analysis revealed that a steady state population of the Q189E variant contains a covalently bound galactosyl moiety. Liquid chromatographic/mass spectrometric analysis of fragmented proteolytic digests identified the site of labeling not as Glu-189 but, surprisingly, as the sequentially adjacent Asp-190. However, the side chain carboxylate of Asp-190 is located 8.9 A away from the donor substrate in the available crystal structure. Kinetic analysis of a D190N mutant at this position revealed a k(cat) value 3000-fold lower than that of the wild type enzyme. A 2.6-A crystal structure of the Q189E mutant with bound uridine 5'-diphospho-2-deoxy-2-fluoro-alpha-d-galactopyranose revealed no significant perturbation of the mode of donor sugar binding nor of active site configuration. This is the first trapping of an intermediate in the active site of a retaining glycosyltransferase and, although not conclusive, implicates Asp-190 as an alternative candidate catalytic nucleophile, thereby rekindling a longstanding mechanistic debate.
Synthesis, structure–activity relationship studies and biological evaluation of novel 2,5‐disubstituted indole derivatives as anticancer agents (2016)

Three novel series of 2,5-disubstituted indole derivatives were synthesized and evaluated in vitro for their antiproliferative activity against human cancer cells and HIV-1 inhibition activity used as a readout of cellular activity. Most compounds were found to have potent anticancer activity. In particular, 2c and 3b which showed effectively to repress HIV-1 transcription had a pan antiproliferative activity in cervical cancer cells (HeLa), breast cancer cells (MCF-7), liver cancer cells (HepG2), and lung cancer cells (H460 and A549). While 3b exhibited high sensitivity to A549 cells with the IC<sub>50</sub> value 0.48 ± 0.15 μm, 2c showed high selectivity toward HepG2 cells with the IC<sub>50</sub> value 13.21 ± 0.30 μm. With respect to the cellular mechanism of action, HepG2 cells treated with 2c and A549 cells treated with 3b for 24 h were studied by annexin V/PI staining and Western blot analysis, and results revealed that 2c and 3b may induce cancer cells apoptosis through inhibiting the phosphorylation at Ser2 of RNAPII CTD which can be phosphorylated by cyclin-dependent kinase 9. These studies indicated that 2c and 3b may develop as potent lead compounds in the therapy of cancer. However, determining their roles in preventing HIV-1 still requires further intensive study.
Effects of cytokines on synthesis and function of the hepatic asialoglycoprotein receptor (1994)

In this study we have investigated whether cytokines, critical mediators of the immune response, might have a direct effect on the expression and/or function of the human hepatic asialoglycoprotein receptor (ASGPR). Binding and uptake of asialoglycoproteins by the human hepatoma cell line, HepG2, and by freshly isolated rat hepatocytes were inhibited by 50% after 3-6 hours and completely abolished following a 24 hour exposure to tumor necrosis factor (TNF) alpha, interferon (INF) alpha or gamma, or interleukin-2 (IL-2). The loss of ASGPR binding activity mediated by IL-2 was reversible up to 4 hours of exposure and accompanied by the selective phosphorylation of the cell-surface receptor. Steady-state levels of total cellular ASGPR protein remained unchanged over the first 6 hours of IL-2 incubation but declined in a dose dependent manner thereafter. This down regulation of ASGPR expression was due to reduced synthesis as a result of reduced receptor transcript levels. No loss was detected, however, of cell surface-associated receptor protein even after 24 hours of IL-2 incubation, suggesting that cytokine induced phosphorylation constitutes a mechanism to regulate receptor activity.
High-Speed NTT-based Polynomial Multiplication Accelerator for Post-Quantum Cryptography (2021)

This paper demonstrates an architecture for accelerating the polynomial multiplication using number theoretic transform (NTT). Kyber is one of the finalists in the third round of the NIST post-quantum cryptography standardization process. Simultaneously, the performance of NTT execution is its main challenge, requiring large memory and complex memory access pattern. In this paper, an efficient NTT architecture is presented to improve the respective computation time. We propose several optimization strategies for efficiency improvement targeting different performance requirements for various applications. Our NTT architecture, including four butterfly cores, occupies only 798 LUTs and 715 FFs on a small Artix-7 FPGA, showing more than 44% improvement compared to the best previous work. We also implement a coprocessor architecture for Kyber KEM benefiting from our high-speed NTT core to accomplish three phases of the key exchange in 9, 12, and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\mathbf{19}\mu \mathbf{s}$</tex> , respectively, operating at 200 MHz.
Unique chemistries of metal-nitrate precursors to form metal-oxide thin films from solution: materials for electronic and energy applications (2019)

Unique chemistries of metal-nitrate precursors that enable the preparation of high-quality, high-performance metal-oxide thin films by solution deposition are reviewed.
In Vivo X-Ray Imaging of Phosphor-Doped PDMS and Phosphor-Doped Aerogel Biomaterials (2015)

Noninvasive rapid in vivo imaging and detection of biomedical implants is a critical part of the design and implementation of smart implants. Thermographic phosphors offer a precise and remotely accessible sensing method that has been utilized here. We present the first in vivo X-ray images of La2O2S:Eu-doped crosslinked silica aerogels and polydimethylsiloxane (PDMS) with increasing dopant concentrations. Results show that native PDMS and crosslinked silica aerogel do not show noticeable attenuation of X-rays while image analysis yields values of the absorption coefficient of 0.014 for the doped aerogel and a range of 0.015–0.017 for the doped PDMS.
Global Identification of Multiple Substrates for<i>Plasmodium falciparum</i>SUB1, an Essential Malarial Processing Protease (2011)

The protozoan pathogen responsible for the most severe form of human malaria, Plasmodium falciparum, replicates asexually in erythrocytes within a membrane-bound parasitophorous vacuole (PV). Following each round of intracellular growth, the PV membrane (PVM) and host cell membrane rupture to release infectious merozoites in a protease-dependent process called egress. Previous work has shown that, just prior to egress, an essential, subtilisin-like parasite protease called PfSUB1 is discharged into the PV lumen, where it directly cleaves a number of important merozoite surface and PV proteins. These include the essential merozoite surface protein complex MSP1/6/7 and members of a family of papain-like putative proteases called SERA (serine-rich antigen) that are implicated in egress. To determine whether PfSUB1 has additional, previously unrecognized substrates, we have performed a bioinformatic and proteomic analysis of the entire late asexual blood stage proteome of the parasite. Our results demonstrate that PfSUB1 is responsible for the proteolytic processing of a range of merozoite, PV, and PVM proteins, including the rhoptry protein RAP1 (rhoptry-associated protein 1) and the merozoite surface protein MSRP2 (MSP7-related protein-2). Our findings imply multiple roles for PfSUB1 in the parasite life cycle, further supporting the case for considering the protease as a potential new antimalarial drug target.
Mixed Dithiolate Durene-DT and Monothiolate Phenylethanethiolate Protected Au<sub>130</sub>Nanoparticles with Discrete Core and Core-Ligand Energy States (2011)

A new type of gold nanoparticle with interesting energetics has been created by employing a mixture of dithiol durene (Durene-DT) and monothiol phenylethanethiol (PhC2S) in the synthesis. The average composition of these mixed thiolate clusters is characterized to be Au(130)(Durene-DT)(29)(PhC2S)(22). Continuous quantized core charging behaviors were observed at lower potentials in voltammetric measurements, while ligand reaction and core-ligand interactions were observed at higher potentials. The absorbance spectrum displays discrete absorption bands at ca. 355, 490, 584, and 718 nm. The electrochemical and absorbance features are correlated through the determined energy states and charging energy. Broad near-IR luminescence was observed, associated with significant relaxation of excitation energy. Such interesting optical and electrochemical properties are attributed to the nanoparticle core size, ligand composition, and core-ligand charge delocalization determined by the dithiolate molecular structure.
Sensing Technologies for Grain Crop Yield Monitoring Systems: A Review (2016)

Purpose: Yield monitoring systems are an essential component of precision agriculture. They indicate the spatial variability of crop yield in fields, and have become an important factor in modern harvesters. The objective of this paper was to review research trends related to yield monitoring sensors for grain crops. Methods: The literature was reviewed for research on the major sensing components of grain yield monitoring systems. These major components included grain flow sensors, moisture content sensors, and cutting width sensors. Sensors were classified by sensing principle and type, and their performance was also reviewed. Results: The main targeted harvesting grain crops were rice, wheat, corn, barley, and grain sorghum. Grain flow sensors were classified into mass flow and volume flow methods. Mass flow sensors were mounted primarily at the clean grain elevator head or under the grain tank, and volume flow sensors were mounted at the head or in the middle of the elevator. Mass flow methods used weighing, force impact, and radiometric approaches, some of which resulted in measurement error levels lower than 5% (R 2 = 0.99). Volume flow methods included paddle wheel type and optical type, and in the best cases produced error levels lower than 3%. Grain moisture content sensing was in many cases achieved using capacitive modules. In some cases, errors were lower than 1%. Cutting width was measured by ultrasonic distance sensors mounted at both sides of the header dividers, and the errors were in some cases lower than 5%. Conclusions: The design and fabrication of an integrated yield monitoring system for a target crop would be affected by the selection of a sensing approach, as well as the layout and mounting of the sensors. For accurate estimation of yield, signal processing and correction measures should be also implemented.
Optimierung des Herstellungsprozesses von Natrium-Cellulosesulfat (NaCS) zur Mikroverkapselung von Zellkulturen (2002)

No translation.
Chlorogenic acids and other cinnamates - nature, occurrence, dietary burden, absorption and metabolism (2000)

This paper summarises the occurrence in foods and beverages of the cinnamic acids, their associated conjugates and transformation products. Quantitative data are lacking for some commodities known to contain them, but it is clear that for many people coffee will be the major source. The daily dietary intake of total cinnamates may vary substantially from almost zero to perhaps close to 1 g. The data relating to their absorption and metabolism are presented along with a consideration of their possible in vivo effects. Data for true bioavailability are incomplete: in particular it is not clear whether availability differs markedly with the form of the conjugate, and whether as a consequence some dietary sources may be superior to others. © 2000 Society of Chemical Industry
A Scalable Multi-channel Parallel NAND Flash Memory Controller Architecture (2011)

With more data-intensive applications appearing in the present social life, the NAND flash memory acting as a replacement candidate of hard disk drives is popularly used in some data centers due to its lower power consumption, faster random access, and higher shock resistance. But the traditional solid state disk exposes the limitation of bandwidth. To this end, we deliver the scalable multi-channel flash memory controller architecture in this paper to exploit the parallelism of multiple chips. It supports all the flash operations, and boosts the performance by evenly distributing multiple accesses among different chips when using the error correction code to improve its reliability. The functions of the multi-channel parallel controller are validated according to a wide spread of workloads. And the evaluation results show that our proposed eight-channel controller outperforms the traditional controller by more than three times and can be well scaled to be 128 channels without extra critical timing path.