A Serum Antigen (Australia Antigen) in Down's Syndrome, Leukemia, and Hepatitis (1967)

Article1 May 1967A Serum Antigen (Australia Antigen) in Down's Syndrome, Leukemia, and HepatitisBARUCH S. BLUMBERG, M.D., D.PHIL., F.A.C.P., BETTY JANE S. GERSTLEY, M.D., DAVID A. HUNGERFORD, PH.D., W. THOMAS LONDON, M.D., ALTON I. SUTNICK, M.D., F.A.C.P.BARUCH S. BLUMBERG, M.D., D.PHIL., F.A.C.P., BETTY JANE S. GERSTLEY, M.D., DAVID A. HUNGERFORD, PH.D., W. THOMAS LONDON, M.D., ALTON I. SUTNICK, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-924 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe have previously reported the presence of an isoantigen of human sera, rare or absent in normal U. S. and northern European populations but relatively common in patients with leukemia (1, 2). The "new" isoantigen has been called "Australia antigen" because it was first found in the serum of an Australian aborigine. It appears to be different from the low-density lipoprotein isoantigen system first described in our laboratory (3-5). Hemophilia patients and others who have received multiple transfusions may develop precipitating isoantibodies against Australia antigen. These precipitating isoantibodies react with a protein in the blood of some normal and some...References1. BLUMBERG BS: Polymorphism of serum proteins and the development of iso-precipitins in transfused patients. Bull. N. Y. Acad. Med. 40: 377, 1964. MedlineGoogle Scholar2. BLUMBERGALTERVISNICH BSHJS: A "new" antigen in leukemia sera. JAMA 191: 541, 1965. CrossrefMedlineGoogle Scholar3. ALLISONBLUMBERG ACBS: An isoprecipitin reaction distinguishing human serum-protein types. Lancet 1: 634, 1961. CrossrefMedlineGoogle Scholar4. BLUMBERGALLISON BSAC: Studies on the isoprecipitin-determined human serum polymorphism, in Proceedings of the International Congress on Human Genetics, 2nd (Rome). Istituto Gregorio Mendel, Rome, 1961, pp. 733-736. Google Scholar5. BLUMBERGDRAYROBINSON BSSJC: Antigen polymorphism of a low-density betalipoprotein. Allotypy in human serum. Nature (London) 194: 656, 1962. CrossrefMedlineGoogle Scholar6. ALTERBLUMBERG HJBS: Studies on a "new" human isoprecipitin system (Australia antigen). Blood 27: 297, 1966. CrossrefMedlineGoogle Scholar7. MELARTINBLUMBERG LBS: Production of antibody against "Australia antigen" in rabbits. Nature (London) 210: 1340, 1966. CrossrefMedlineGoogle Scholar8. BLUMBERGMELARTINGUINTOWERNER BSLRAB: Family studies of a "new" human serum isoantigen system (Australia antigen). Amer. J. Hum. Genet. 18: 594, 1966. MedlineGoogle Scholar9. BLUMBERGALTER BSHJ: Precipitating antibodies against a serum protein ("Australia antigen") in the serum of transfused hemophilia patients (abstract). J. Clin. Invest. 44: 1029, 1965. Google Scholar10. BLUMBERG BS: An inherited serum isoantigen in leukemia and Down's syndrome (abstract). J. 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STOLLERCOLLMAN ARD: Incidence of infectious hepatitis followed by Down's syndrome nine months later. Lancet 2: 1221, 1965. CrossrefMedlineGoogle Scholar25. MELLALANG BDJ: Leucocyte mitosis: suppression in vitro associated with acute infectious hepatitis. Science 155: 80, 1967. CrossrefMedlineGoogle Scholar26. FAILKOWUCHIDAHECHTMOTULSKY PJIFAG: Increased frequency of thyroid auto-antibodies in mothers of patients with Down's syndrome. Lancet 2: 868, 1965. CrossrefMedlineGoogle Scholar27. ROBINSONPUCK ATT: Sex chromatin in newborns; presumptive evidence for external factors in human nondisjunctions. Science 148: 83, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BARUCH S. BLUMBERG, M.D., D.PHIL., F.A.C.P.; BETTY JANE S. GERSTLEY, M.D.; DAVID A. HUNGERFORD, PH.D.; W. THOMAS LONDON, M.D.; ALTON I. SUTNICK, M.D., F.A.C.P.Affiliations: Philadelphia, PennsylvaniaFrom the Institute for Cancer Research, Fox Chase, Philadelphia, Pa.This study was supported by research grants CA-06551, CA-08069, and FR-05539, the National Cancer Institute, the National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Baruch S. Blumberg, M.D., The Institute for Cancer Research, 7701 Burholme Ave., Fox Chase, Philadelphia, Pa. 19111. 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