gebhart/patrepeval huggingface dataset:
Investigation of Multiple Panel Reinforced Concrete Floor Slabs (1963)

First Name is required invalid characters Last Name is required invalid characters Email Address is required Invalid Email Address Invalid Email Address
Speech Dialogue with Facial Displays: Multimodal Human-Computer Conversation (1994)

Human face-to-face conversation is an ideal model for human-computer dialogue. One of the major features of face-to-face communication is its multiplicity of communication channels that act on multiple modalities. To realize a natural multimodal dialogue, it is necessary to study how humans perceive information and determine the information to which humans are sensitive. A face is an independent communication channel that conveys emotional and conversational signals, encoded as facial expressions. We have developed an experimental system that integrates speech dialogue and facial animation, to investigate the effect of introducing communicative facial expressions as a new modality in human-computer conversation. Our experiments have shown that facial expressions are helpful, especially upon first contact with the system. We have also discovered that featuring facial expressions at an early stage improves subsequent interaction.
Parents' Inclusion and Primary Prevention of Behaviour Disorders in Children in a Pre-school Institution (1998)

This work starts from the presumption that the empowerment of parents for their parental function, in the most important period of the child's development, is almost the only way to affect the process and results of the child's primary socialization. The path of empowerment is actually a path of investment in the primary prevention of behaviour disorders in children and youth being carried out in an interaction between the family (parents) and the institution of pre-school education. On a sample of (92) parents of pre-school children, a model of working with groups of parents in the year before their children start primary school will be presented. The model explains how parents are to be guided towards becoming aware of their own perception of the child's prepareness for school, the perception of the forms of behaviour the child masters or should acquire and the ways of teaching new modes of behaviour related to school. The factor analysis established four factors which explain the parents' self-assessment of their prepareness for the child starting school and four factors explaining the parents' assessment of the child's prepareness for school. Key words: primary prevention of behaviour disorders, pre-school age children, prepareness for school, parents, kindergarten.
Electrogenerated Chemiluminescence from a CdSe Nanocrystal Film and Its Sensing Application in Aqueous Solution (2004)

Electrogenerated chemiluminescence (ECL) of semiconductor quantum dots in aqueous solutions and its first sensing application were studied by depositing CdSe nanocrystals (NCs) on a paraffin-impregnated graphite electrode (PIGE). The CdSe nanocrystal thin film exhibited two ECL peaks at -1.20 (ECL-1) and -1.50 V (ECL-2) in pH 9.3, 0.1 M PBS during the cyclic sweep between 0 and -1.8 V at 20 mV s(-1). The electron-transfer reaction between individual electrochemically reduced nanocrystal species and oxidant coreactants such as H(2)O(2) and reduced dissolved oxygen led to ECL-1. When mass NCs packed densely in the film were reduced electrochemically, assembly of reduced nanocrystal species could react with coreactants to produce another ECL signal, ECL-2. ECL-1 showed higher sensitivity to the concentration of oxidant coreactants than ECL-2 and thus was used for ECL detection of coreactant, H(2)O(2). A linear response of ECL-1 to H(2)O(2) was observed in the concentration range of 2.5 x 10(-7)-6 x 10(-5) M with a detection limit of 1.0 x10(-7) M. The fabrication of 10 CdSe nanocrystal thin-film modified PIGEs displayed an acceptable reproducibility with a RSD of 1.18% obtained at H(2)O(2) level of 10 microM.
Targeting Natural Killer Cells to Acute Myeloid Leukemia<i>In Vitro</i>with a CD16 × 33 Bispecific Killer Cell Engager and ADAM17 Inhibition (2013)

CD16 × 33 BiKE can overcome self-inhibitory signals and effectively elicit NK cell effector activity against AML. These in vitro studies highlight the potential of CD16 × 33 BiKE ± ADAM17 inhibition to enhance NK cell activation and specificity against CD33(+) AML, which optimally could be applied in patients with relapsed AML or for adjuvant antileukemic therapy posttransplantation.
A region-based memory manager for prolog (2000)

We extend Tofte and Talpin's region-based model for memory management to support backtracking and cuts, which makes it suitable for use with Prolog and other logic programming languages. We describe how the extended model can be implemented and report on the performance of a prototype implementation. The prototype implementation performs well when compared to a garbage-collecting Prolog implementation using comparable technology for non-memory-management issues.
A Poly(propylene imine) (DAB-Am-64) Dendrimer as Cu<sup>2+</sup> Chelator for the Synthesis of Copper Oxide Clusters Embedded in Sol−Gel Derived Matrixes (2002)

The fifth generation poly(propylene)imine dendrimer (DAB-Am-64) was used as a macrochelating agent to produce well-dispersed CuO nanoclusters embedded in a silica sol−gel derived matrix. Several characterization methods, including X-ray absorption and diffuse reflectance Fourier transform IR spectroscopies, temperature-programmed oxidation, transmission electron microscopy, and X-ray diffraction, were used for the characterization of the materials. The presence of Cu was found to catalyze the oxidative removal of the dendrimer guest from the silica matrix. The proposed synthetic method, which is expected to be useful for a range of transition metal (e.g., Cu, Ni, Co, Pd, Pt, and Zn) ions with some affinity for amine-type ligands, is viewed as particularly suitable for the synthesis of model supported catalysts and materials with unusual magnetic and optical properties.
Precision Determination of Lattice Constants with a Geiger-Counter X-Ray Diffractometer (1955)

It is shown that the Geiger-counter x-ray diffractometer can be used for precision determination of lattice constants. The zero point of the goniometer (determined by two methods) and the position of the diffraction lines ($2\ensuremath{\theta}$) were obtained with an accuracy of \ifmmode\pm\else\textpm\fi{}0.001\ifmmode^\circ\else\textdegree\fi{}. The temperature was kept constant by a special unit within 0.05\ifmmode^\circ\else\textdegree\fi{}C. An investigation of the systematic errors was made, which shows that the extrapolation of lattice constants vs ${cos}^{2}\ensuremath{\theta}$, according to Wilson's equation, is permissible and the vertical divergence error, as computed by Eastabrook, lies within our tolerances for $2\ensuremath{\theta}$ up to 165\ifmmode^\circ\else\textdegree\fi{} and may be neglected. The lattice constants of Al, Ag, Ge, Si, Ca${\mathrm{F}}_{2}$, CsI, TlCl, and TlBr, determined by extrapolation, are in good agreement with published data. The limiting factor in the accuracy of the lattice constant determination is not in the error of the diffractometer, but in the x-ray wavelength.
Loss of Astrocytic Domain Organization in the Epileptic Brain (2008)

Gliosis is a pathological hallmark of posttraumatic epileptic foci, but little is known about these reactive astrocytes beyond their high glial fibrillary acidic protein (GFAP) expression. Using diolistic labeling, we show that cortical astrocytes lost their nonoverlapping domain organization in three mouse models of epilepsy: posttraumatic injury, genetic susceptibility, and systemic kainate exposure. Neighboring astrocytes in epileptic mice showed a 10-fold increase in overlap of processes. Concurrently, spine density was increased on dendrites of excitatory neurons. Suppression of seizures by the common antiepileptic, valproate, reduced the overlap of astrocytic processes. Astrocytic domain organization was also preserved in APP transgenic mice expressing a mutant variant of human amyloid precursor protein despite a marked upregulation of GFAP. Our data suggest that loss of astrocytic domains was not universally associated with gliosis, but restricted to seizure pathologies. Reorganization of astrocytes may, in concert with dendritic sprouting and new synapse formation, form the structural basis for recurrent excitation in the epileptic brain.
The evidence is in. Why are IUDs still out?: family physicians' perceptions of risk and indications. (2008)

A substantial proportion of surveyed FPs believed that the side effects of IUDs were more severe than is supported by clinical guidelines and were misinformed about the range of women who could benefit from IUDs. These misconceptions likely contribute to the low rate of IUD use in Canada.
The Impact of Health on the Ability of Older Australians to Stay in the Workforce - with Possible Contributions to Economic Sustainability (2004)

The ageing of the population, combined with increasing life expectancies, is raising concerns about the sustainability of current economic and social structures. This paper studies the likelihood and impact of more older Australians staying in the labour force - subject to individuals’ own health, socioeconomic status (SES), sex, age and family characteristics. A dynamic microsimulation model is used to estimate the probability that, in a changed employment environment, more Australians aged 65-70 would work more than 15 hours per week. Under that scenario, the findings are that around 500,000 additional persons aged 65-70 years would remain in the workforce - with the related earnings totalling up to $20 billion in 1998 ($35 billion in 2018). The estimated savings by government on the age pension would be around $2 billion ($4 billion in 2018).
Secreted Frizzled-Related Protein 1 Modulates Glucocorticoid Attenuation of Osteogenic Activities and Bone Mass (2005)

Prolonged glucocorticoid treatment is known to cause osteoporosis or aseptic necrosis. Secreted frizzled-related proteins 1 (SFRP1) and low-density lipoprotein-related protein 5 (LRP5), a Wnt protein antagonist and a coreceptor, have been found to regulate skeletogenesis. Whereas recent studies have reported that excess glucocorticoid promotes bone loss, the biological role of SFRP1 and LRP5 in regulating glucocorticoid attenuation of bone formation is not fully understood. We showed that a supraphysiological level of glucocorticoid enhanced SFRP1 but not LRP5 expression of primary mesenchymal cell cultures in vitro and osteoblasts at metaphyseal trabecular endosteum and chondrocytes at calcified cartilage in vivo. Glucocorticoid augmentation of SFRP1 expression was transcriptionally mediated. The inhibitory action of glucocorticoid on osteogenic differentiation appeared to be regulated by SFRP1 mediation of beta-catenin destabilization because knocking down SFRP1 by RNA interference abrogated the supraphysiological level of glucocorticoid attenuation of osteogenesis. Recombinant human SFRP1 reduced the promoting effect of physiological level of glucocorticoid on cytosolic beta-catenin accumulation, runt-related transcription factor-2 activation, and osteogenic activities. Glucocorticoid and recombinant human SFRP1 significantly increased osteochondral cell apoptosis associated with reduced mineral density, biomechanical properties, trabecular bone volume, and midshaft cortical bone areas in rat femurs. These findings suggest that SFRP1 modulates glucocorticoid-induced bone loss. Regulation of Wnt/SFRP signal transduction can be used in the future as an alternative strategy for the prevention of glucocorticoid-induced osteoporosis.
Detection of Severe Human Metapneumovirus Infection by Real-Time Polymerase Chain Reaction and Histopathological Assessment (2005)

Our results provide in situ evidence of hMPV infection in humans and suggest that hMPV is a cause of clinically severe lower respiratory tract infection that can be detected during bronchoscopy by use of real-time PCR and routine histopathological assessment.
Superhydrophobic Transparent Surface of Nanostructured Poly(Methyl Methacrylate) Enhanced by a Hydrolysis Reaction (2013)

Abstract We report a method to create a self‐cleaning, transparent surface on poly(methyl methacrylate) (PMMA) using a dry etching with CF 4 plasma and a subsequent hydrolysis process with water immersion. During the CF 4 plasma treatment, nanoscale pillar structures were formed and its aspect ratio tended to increase. However, the transparency was reduced due to the deposition and the accumulation of undesired capping layers, which cover the structures. The hydrolysis was used to remove the capping layers of metal fluoride. As a result, the surface improves their clarity based on the transmittance up to 95%, because the reflectivity was reduced. With a subsequent hydrophobic coating, a superhydrophobic surface was achieved showing robust anti‐wetting and anti‐dewing effects. magnified image
The Enzymatic Synthesis of D-Alanyl-D-alanine. III. On the Inhibition of D-Alanyl-D-alanine Synthetase by the Antibiotic D-Cycloserine<sup>*</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Enzymatic Synthesis of D-Alanyl-D-alanine. III. On the Inhibition of D-Alanyl-D-alanine Synthetase by the Antibiotic D-Cycloserine*Francis C. Neuhaus and Judy L. LynchCite this: Biochemistry 1964, 3, 4, 471–480Publication Date (Print):April 1, 1964Publication History Published online1 May 2002Published inissue 1 April 1964https://pubs.acs.org/doi/10.1021/bi00892a001https://doi.org/10.1021/bi00892a001research-articleACS PublicationsRequest reuse permissionsArticle Views457Altmetric-Citations130LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On Convergence Properties of the EM Algorithm for Gaussian Mixtures (1996)

We build up the mathematical connection between the “Expectation-Maximization” (EM) algorithm and gradient-based approaches for maximum likelihood learning of finite gaussian mixtures. We show that the EM step in parameter space is obtained from the gradient via a projection matrix P, and we provide an explicit expression for the matrix. We then analyze the convergence of EM in terms of special properties of P and provide new results analyzing the effect that P has on the likelihood surface. Based on these mathematical results, we present a comparative discussion of the advantages and disadvantages of EM and other algorithms for the learning of gaussian mixture models.
Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed (2010)

Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of "soft" neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population-based cohort study in Tuscany, Italy. PD was defined based on standard criteria. "Soft" neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance-based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction.
Hyperspectral Microscopy of Near-Infrared Fluorescence Enables 17-Chirality Carbon Nanotube Imaging (2015)

The intrinsic near-infrared photoluminescence (fluorescence) of single-walled carbon nanotubes exhibits unique photostability, narrow bandwidth, penetration through biological media, environmental sensitivity, and both chromatic variety and range. Biomedical applications exploiting this large family of fluorophores will require the spectral and spatial resolution of individual (n,m) nanotube species' fluorescence and its modulation within live cells and tissues, which is not possible with current microscopy methods. We present a wide-field hyperspectral approach to spatially delineate and spectroscopically measure single nanotube fluorescence in living systems. This approach resolved up to 17 distinct (n,m) species (chiralities) with single nanotube spatial resolution in live mammalian cells, murine tissues ex vivo, and zebrafish endothelium in vivo. We anticipate that this approach will facilitate multiplexed nanotube imaging in biomedical applications while enabling deep-tissue optical penetration, and single-molecule resolution in vivo.
Cost-effectiveness of stereotactic core needle biopsy: analysis by means of mammographic findings. (1997)

Cost savings of stereotactic core needle biopsy vary in subgroups of patients defined according to mammographic findings. Over-all savings will depend on the distribution of patients among these groups. In this series, cost savings were realized with stereotactic core biopsy over open surgical biopsy for all mammographic subgroups.
Optimal filtering for linear systems with state and multiple observation delays (2008)

This article solves the optimal filtering problem for linear systems with state and multiple observation delays. The optimal estimate equation similar to the traditional Kalman–Bucy one is derived, and the system of equations for determining the filter gain matrix consists of an infinite set of equations. It is then demonstrated that a finite set of the filtering equations can be obtained in case of commensurable delays. In the example, the designed optimal filter is compared to the traditional Kalman–Bucy filter.
Nanoscale Imaging and Spectroscopy of Plasmonic Modes with the PTIR Technique (2014)

The photothermal induced resonance (PTIR) method measures the near-field absorption in gold plasmonic structures. PTIR absorption images show the interference between the bright and dark modes of asymmetric split ring resonators (ASRRs). The plasmonic absorption spectra of the ASRRs individual arcs are obtained locally, confirming the collective nature of the plasmonic excitation. Scale bars are 500 nm.
Isolation and Reconstitution of Cytochrome P450ox and in Vitro Reconstitution of the Entire Biosynthetic Pathway of the Cyanogenic Glucoside Dhurrin from Sorghum (1997)

A cytochrome P450, designated P450ox, that catalyzes the conversion of (Z)-p-hydroxyphenylacetaldoxime (oxime) to p-hydroxymandelonitrile in the biosynthesis of the cyanogenic glucoside beta-D-glucopyranosyloxy-(S)-p-hydroxymandelonitrile (dhurrin), has been isolated from microsomes prepared from etiolated seedlings of sorghum (Sorghum bicolor L. Moench). P450ox was solubilized using nonionic detergents, and isolated by ion-exchange chromatography, Triton X-114 phase partitioning, and dye-column chromatography. P450ox has an apparent molecular mass of 55 kD, its N-terminal amino acid sequence is -ATTATPQLLGGSVP, and it contains the internal sequence MDRLVADLDRAAA. Reconstitution of P450ox with NADPH-P450 oxidoreductase in micelles of L-alpha-dilauroyl phosphatidylcholine identified P450ox as a multifunctional P450 catalyzing dehydration of (Z)-oxime to p-hydroxyphenylaceto-nitrile (nitrile) and C-hydroxylation of p-hydroxyphenylacetonitrile to nitrile. P450ox is extremely labile compared with the P450s previously isolated from sorghum. When P450ox is reconstituted in the presence of a soluble uridine diphosphate glucose glucosyltransferase, oxime is converted to dhurrin. In vitro reconstitution of the entire dhurrin biosynthetic pathway from tyrosine was accomplished by the insertion of CYP79 (tyrosine N-hydroxylase), P450ox, and NADPH-P450 oxidoreductase in lipid micelles in the presence of uridine diphosphate glucose glucosyltransferase. The catalysis of the conversion of Tyr into nitrile by two multifunctional P450s explains why all intermediates in this pathway except (Z)-oxime are channeled.
Nucleotide sequence of 3' untranslated portion of human alpha globin mRNA (1977)

We have determined the nucleotide sequence of 75 nucleotides of the 3'-untranslated portion of normal human α globin mRNA which corresponds to the elongated amino acid sequence of the chain termination mutant Hb Constant Spring. This was accomplished by sequence analysis of cDNA fragments obtained by restriction endonuclease or T4 endonuclease IV cleavage of human globin cDNA synthesized from globin mRNA by use of viral reverse transcriptase. Analysis of cRNA synthesized from cDNA by use of RNA polymerase provided additional confirmatory sequence information. Possible polymorphism has been identified at one site of the sequence. Our sequence overlaps with, and extends the sequence of 43 nucleotides determined by Proudfoot and coworkers for the very 3'-terminal portion of human α globin mRNA. The complete 3'-untranslated sequence of human a globin mRNA (112 nucleotides including termination codon) shows little homology to that of the human or rabbit β globin mRNAs except for the presence of the hexanucleotide sequence AAUAAA which is found in most eukaryotic mRNAs near the 3' poly(A).
Do Allelic Variants in α <sub>2A</sub> and α <sub>2C</sub> Adrenergic Receptors Predispose to Hypertension in Blacks? (2006)

Sequence variations in the human alpha2 adrenergic receptor genes (ADRA2A and ADRA2C) have been implicated as a cause of hypertension in blacks. Although certain alleles are selectively enriched in blacks, their association with hypertension is based on small convenience samples and has not been evaluated in larger populations. From a stratified random population sample of 3398 individuals (52% blacks), we obtained DNA samples together with an in-home health interview, 10 in-home measurements of blood pressure, and cardiac MRI. We tested for associations among hypertension, untreated blood pressure, and parameters of hypertensive heart disease with 2 alleles, a DraI restriction fragment length polymorphism in the ADRA2A gene and a deletion of residues 322 to 325 in the ADRA2C gene. Although both alleles were selectively enriched in this black population, we found no association of either allele with hypertension, untreated blood pressure, or any of the cardiac function parameters. In a logistic model that controlled for age, body mass index, diabetes, and smoking, the adjusted odds ratio (OR) for hypertension was 1.0 (95% CI, 0.8 to 1.2), and 1.0 (95% CI, 0.9 to 1.2) for ADRA2A and ADRA2C variant alleles. In subjects not receiving prescription blood pressure medication, neither of these alleles, alone or in combination, was predictive of blood pressure, heart rate, left ventricular mass, cardiac output, systemic vascular resistance, or aortic compliance. Both the DraI restriction fragment length polymorphism in ADRA2A and the ADRA2C (Del 322 to 325) can be excluded as major candidate alleles for hypertension in blacks.