gebhart/patrepeval huggingface dataset:
Fludarabine, mitoxantrone, dexamethasone (FND) compared with an alternating triple therapy (ATT) regimen in patients with stage IV indolent lymphoma (2002)

Treatment for patients with stage IV indolent lymphoma ranges from watchful waiting to intensive chemotherapy and stem cell transplantation. In this trial we compared 2 induction regimens followed by 1 year of interferon maintenance therapy. Fludarabine, mitoxantrone (Novantrone), and dexamethasone (FND) were compared with an alternating triple therapy (ATT) regimen (CHOD-Bleo, ESHAP, and NOPP). Maintenance interferon/dexamethasone was given for 1 year in both treatment arms. Endpoints were comparisons of remission rates, survival, failure-free survival (FFS), molecular response rates, and toxicities. One hundred forty-two patients with previously untreated stage IV indolent lymphoma were evaluable (73 on FND; 69 on ATT). The overall response rates were 97% for FND and 97% for ATT (P =.9). The median follow-up is 5.9 years. The 5-year survival rates were 84% with FND and 82% with ATT (P =.9); the 5-year FFS rates were 41% with FND and 50% with ATT (P =.02). In a multivariate analysis, factors predicting for longer FFS were beta(2)-microglobulin less than 3 mg/L (P =.01) and ATT treatment (P =.03). ATT was associated with a substantially higher rate of grade 3-4 toxicities than FND. In conclusion, both regimens were associated with high rates of response and survival. ATT was associated with substantially longer FFS, but it was more toxic than FND.
Estimating the Power of the Two-Sample Wilcoxon Test for Location Shift (1988)

Traditional methods for calculating the power of a statistical test for location shift require knowledge of the shape of the underlying probability distribution. The distribution shape, however, may be unknown. This paper describes a bootstrap method for using observed data (or pilot data) to approximate the power. No assumptions need be made about the shape of the underlying continuous probability distribution. Simulation evidence shows that, when applied to the Wilcoxon two-sample test for location shift, the suggested method is reliable. The evidence also shows that it is more accurate than a benchmark traditional approach. The bootstrap method is applied to a real-data example. The analysis demonstrates how the method can be used to determine sample sizes and how to choose the more powerful of two alternative tests for location shift.
Surface Membrane Biotinylation Efficiently Mediates the Endocytosis of Avidin Bioconjugates into Nucleated Cells (1999)

Here we demonstrate that biotin covalently attached to cell surface obligates existing receptors to endocytose avidin bioconjugates into nucleated cells. Incubation of fluorescein-labeled avidin with biotinylated cell lines resulted in uniform and rapid surface attachment and endocytosis compared with no detectable association of the avidin-conjugated dye with unbiotinylated cells. Uptake was detected within minutes with efficiencies approaching 100% in cell lines and freshly obtained peripheral blood mononuclear cells. After 24 h, avidin was barely detectable on the surface of the nucleated cells. In marked contrast, fluorescent avidin remained exclusively on the external membrane of erythrocytes after 24 h. To investigate biotin-mediated endocytosis for the delivery of DNA, we prepared polyethylenimine-avidin (PEI-avidin) conjugates. Surface biotinylation significantly increased the transfection efficiencies of PEI-avidin condensed plasmid DNA coding green fluorescent protein (GFP) to the level of transferrin-receptor targeted gene delivery (15-20% GFP positive cells in culture after 48 h). The increase in transfection efficiency was blocked by the addition of free avidin or biotin to the culture medium. Biotin covalently bound to cell surface membrane proteins efficiently mediates the entry of avidin bioconjugates into nucleated cells.
Wavelet regression by cross-validation, (1994)

This paper is about using wavelets for regression. The main aim of the paper is to introduce and develop a cross-validation method for selecting a wavelet regression threshold that produces good estimates with respect to L2 error. The selected threshold determines which coefficients to keep in an orthogonal wavelet expansion of noisy data and acts in a similar way to a smoothing parameter in non-parametric regression. The paper gives a very brief introduction to wavelets and how the discrete wavelet transform with a thresholding rule can be used to estimate functions from noisy data. The paper examines the integrated square error (ISE) of a soft-thresholded wavelet estimator as a function of the threshold and shows that the ISE is almost always convex and almost always has negative first derivative for a zero threshold. This implies that it is almost always possible to find a unique minimum for the ISE. A cross-validation score is introduced to estimate the ISE of a softthresholded est...
The Aldehydic Constituents from the Ethanolysis of Spruce and Maple Woods (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Aldehydic Constituents from the Ethanolysis of Spruce and Maple WoodsLeo. Brickman, James J. Pyle, and Harold. HibbertCite this: J. Am. Chem. Soc. 1939, 61, 2, 523Publication Date (Print):February 1, 1939Publication History Published online1 May 2002Published inissue 1 February 1939https://pubs.acs.org/doi/10.1021/ja01871a503https://doi.org/10.1021/ja01871a503research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Soil carbon and climate change: from the Jenkinson effect to the compost‐bomb instability (2010)

First generation climate–carbon cycle models suggest that climate change will suppress carbon accumulation in soils, and could even lead to a net loss of global soil carbon over the next century. These model results are qualitatively consistent with soil carbon projections published by Jenkinson almost two decades ago. More recently there has been a suggestion that the release of heat associated with soil decomposition, which is neglected in the vast majority of large‐scale models, may be critically important under certain circumstances. Models with and without the extra self‐heating from microbial respiration have been shown to yield significantly different results. The present paper presents a mathematical analysis of a tipping point or runaway feedback that can arise when the heat from microbial respiration is generated more rapidly than it can escape from the soil to the atmosphere. This ‘compost‐bomb instability’ is most likely to occur in drying organic soils with high porosity covered by an insulating lichen or moss layer. However, the instability is also found to be strongly dependent on the rate of global warming. This paper derives the conditions required to trigger the compost‐bomb instability, and discusses the relevance of these to the concept of dangerous rates of climate change. On the basis of simple numerical experiments, rates of long‐term warming equivalent to 10°C per century could be sufficient to trigger compost‐bomb instability in drying organic soils.
Modified Curvelet Thresholding Algorithm for Image Denoising (2010)

Problem statement: This study introduced an adaptive thresholding method for removing additive white Gaussian noise from digital images. Approach: Curvelet transform employed in the proposed scheme provides sparse decomposition as compared to the wavelet transform methods which being nongeometrical lack sparsity and fail to show optimal rate of convergence. Results: Different behaviors of curvelet transform maxima of image and noise across different scales allow us to design the threshold operator adaptively. Multiple thresholds depending on the scale and noise variance are calculated to locally suppress the curvelet transform coefficients so that the level of threshold is different at every scale. Conclusion/Recommendations: The proposed algorithm succeeded in providing improved denoising performance to recover the shape of edges and important detailed components. Simulation results proved that the proposed method can obtain a better image estimate than the wavelet based restoration methods.
Aging rate of grade 3 presspaper insulation used in power transformers (2014)

Paper materials are used as the insulation of power transformers. Over time these materials slowly degrade, until they reach a point when they no longer function effectively as transformer insulation, and the transformer has then reached its end of life. The aging rate of paper is affected by temperature, water, oxygen and acids. Investigations have been performed previously on Kraft and Kraft thermally upgraded types of paper. However, a different type of paper used in transformer insulation, Grade 3 presspaper (which contains cotton), has not been extensively tested and compared to Kraft paper. In these experiments we studied the aging rate of Grade 3 presspaper and compared it to our previous studies of Kraft paper. Traditionally, the aging rate of paper has been studied in sealed vessels. The problem with this approach is that the chemical environment within the vessel will change during aging, and so the aging rate will be affected. In our experiment setup we controlled the water and oxygen content to more accurately determine the aging rate. Similarly to Kraft paper, the aging rate of Grade 3 presspaper with the same water content increased with oxygen content in the oil. Life curves were developed based on the water content of the paper and the oxygen content of the oil.
Regulation of<i>Pseudomonas aeruginosa</i>corneal infection in IL-1ß converting enzyme (ICE, caspase-1) deficient mice (2004)

These data provide evidence that bacterial infection in the cornea of ICE(-/-) mice induces a reduced inflammatory response by: reduction in PMN and cytokines and chemokines that attract these cells to the cornea; enhanced apoptotic cell death in the infected epithelium; and increased IL-1Ra levels. The data also confirm the importance of IL-1 regulation in this model and suggest that ICE inhibition may be an attractive ancillary therapeutic strategy to control the host response to this pathogen.
Construction of synthetic regulatory networks in yeast (2012)

Yeast species such as Saccharomyces cerevisiae have been exploited by humans for millennia and so it is therefore unsurprising that they are attractive cells to re-engineer for industrial use. Despite many beneficial traits yeast has for synthetic biology, it currently lags behind Escherichia coli in the number of synthetic networks that have been described. While the eukaryotic nature of yeast means that its regulation is not as simple to predict as it is for E. coli, once initial considerations have been made yeast is pleasingly tractable. In this review we provide a loose guide for constructing and implementing synthetic regulatory networks in S. cerevisiae using examples from previous research to highlight available resources, specific considerations and potential future advances.
Preparation and Photosensitized Oxidation of Isopropylidenecyclobutanes and -cyclobutenes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and Photosensitized Oxidation of Isopropylidenecyclobutanes and -cyclobutenesAryeh A. Frimer, Joseph Weiss, Hugo E. Gottlieb, and Joel L. WolkCite this: J. Org. Chem. 1994, 59, 4, 780–792Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/jo00083a019https://doi.org/10.1021/jo00083a019research-articleACS PublicationsRequest reuse permissionsArticle Views850Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Secreted forms of human neutrophil collagenase. (1986)

Collagenase in human neutrophils is found within intracellular granules which can be stimulated to be secreted with phorbol myristic acetate. This extracellular secreted form of neutrophil collagenase was isolated by immunoaffinity chromatography using a monoclonal antibody previously shown to specifically recognize neutrophil collagenase. The enzyme efficiently bound to this column and was eluted with NaSCN as three major species of 75, 57, and 22 kDa, respectively. These proteins were closely related immunologically since, after radiolabeling and separation by gel filtration, each of the three proteins was precipitated by the monoclonal antibody. Also, the 75- and 57-kDa proteins exhibited collagenase activity after elution from polyacrylamide gels run under nondenaturing conditions. Further, the 57-kDa protein autodegraded into a 22-kDa protein with time. Polyclonal antibody, prepared to the 57-kDa enzyme, also recognized the 75- and 22-kDa proteins using an immunoblot technique. When crude neutrophil supernatants containing latent collagenase were immunoblotted, both the 75- and the 57-kDa enzymes were present. Our immunoaffinity purified active enzymes, although activated during the course of purification, resemble the latent enzymes in crude neutrophil supernatants. The multiple forms of secreted collagenase from degranulated leukocytes may resemble more closely that seen in inflammation.
The optimal control in batch arrival queue with server vacations, startup and breakdowns (2004)

This paper studies the N policy M[x]/G/1 queue with server vacations; startup and breakdowns, where arrivals form a compound Poisson process and service times are generally distributed. The server is turned off and takes a vacation whenever the system is empty. If the number of customers waiting in the system at the instant of a vacation completion is less than N, the server will take another vacation. If the server returns from a vacation and finds at least N customers in the system, he is immediately turned on and requires a startup time before providing the service until the system is empty again. It is assumed that the server breaks down according to a Poisson process whose repair time has a general distribution. The system characteristics of such a model are analyzed and the total expected cost function per unit time is developed to determine the optimal threshold of N at a minimum cost.
S<scp>ELECTIVE</scp> T<scp>OXICITY OF</scp> N<scp>EONICOTINOIDS</scp> A<scp>TTRIBUTABLE TO</scp> S<scp>PECIFICITY OF</scp> I<scp>NSECT AND</scp> M<scp>AMMALIAN</scp> N<scp>ICOTINIC</scp> R<scp>ECEPTORS</scp> (2002)

Neonicotinoids, the most important new class of synthetic insecticides of the past three decades, are used to control sucking insects both on plants and on companion animals. Imidacloprid (the principal example), nitenpyram, acetamiprid, thiacloprid, thiamethoxam, and others act as agonists at the insect nicotinic acetylcholine receptor (nAChR). The botanical insecticide nicotine acts at the same target without the neonicotinoid level of effectiveness or safety. Fundamental differences between the nAChRs of insects and mammals confer remarkable selectivity for the neonicotinoids. Whereas ionized nicotine binds at an anionic subsite in the mammalian nAChR, the negatively tipped ("magic" nitro or cyano) neonicotinoids interact with a proposed unique subsite consisting of cationic amino acid residue(s) in the insect nAChR. Knowledge reviewed here of the functional architecture and molecular aspects of the insect and mammalian nAChRs and their neonicotinoid-binding site lays the foundation for continued development and use of this new class of safe and effective insecticides.
Microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent (1985)

The potential of octenidine hydrochloride (WIN 41464-2) as a topical microbicide was measured both by in vitro death kinetics and reductions in numbers of bacteria on the skin of cynomolgus monkeys. Semilogarithmic survival curves were plotted to measure the microbicidal activity of various concentrations of octenidine against Staphylococcus aureus. The microbicidal activity of octenidine was also determined for Staphylococcus epidermidis, Proteus mirabilis, Streptococcus pyogenes, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens, and Candida albicans. Death rates for the same microbial strains were compared with those obtained by using chlorhexidine gluconate. Octenidine concentrations of less than 1.5 microM (0.94 microgram/ml) caused a greater than 99% reduction of each microbial population within 15 min. Staphylococcus epidermidis was the most susceptible of the test organisms, and E. coli and C. albicans were the least susceptible. Octenidine was more active than chlorhexidine against each test strain. Skin-degerming activities of aqueous and formulated octenidine and formulated chlorhexidine were compared in single and multiple applications of these agents to the hand and foot surfaces of monkeys by using a glove-juice extraction procedure to measure the skin microflora. Aqueous octenidine, at a concentration of 0.2 to 1.6% reduced resident microflora populations from 90 to 99.98%, depending on the concentration and number of applications. Octenidine formulated at 2% in a surfactant-based vehicle exhibited significantly better skin-degerming activity than did either a nonmedicated vehicle or the Hibiclens brand of 4% chlorhexidine gluconate.
Alteration of Hemoglobin Oxygenation in the Frontal Region in Elderly Depressed Patients as Measured by Near-infrared Spectroscopy (2000)

In an attempt to elucidate the neurobiological basis of hypofrontality in depression, alterations of oxyhemoglobin and deoxyhemoglobin were examined by using near-infrared spectroscopy of the left frontal region in 9 elderly patients with depressive disorders and 10 control subjects. Verbal repetition task, verbal fluency test, hyperventilation, and paper-bag breathing were performed. During the verbal fluency test, oxyhemoglobin significantly increased and deoxyhemoglobin significantly decreased in control subjects, whereas no significant change was observed in patients. During hyperventilation, oxyhemoglobin significantly decreased and deoxyhemoglobin significantly increased in both groups. These findings suggest that functional hypofrontality in elderly depression is not due to altered vasodilator response.
Coarse grain reconfigurable architecture (embedded tutorial) (2001)

The paper gives a brief survey over a decade of R&D on coarse grain reconfigurable hardware and related compilation techniques and points out its significance to the emerging discipline of reconfigurable computing.
Towards Recommender Systems for Police Photo Lineup (2017)

Photo lineups play a significant role in the eyewitness identification process. This method is used to provide evidence in the prosecution and subsequent conviction of suspects. Unfortunately, there are many cases where lineups have led to the conviction of an innocent suspect. One of the key factors affecting the incorrect identification of a suspect is the lack of lineup fairness, i.e. that the suspect differs significantly from all other candidates. Although the process of assembling fair lineup is both highly important and time-consuming, only a handful of tools are available to simplify the task.
A greasy soil hard surface cleaning test (1984)

Abstract A laboratory screening test for greasy soil removal from hard surfaces using lard, vegetable shortening and vegetable oil darkened with finely divided charcoal on white, latex‐painted masonite wallboard is described. Cleaning by a wet sponge in the Gardner apparatus is measured by reflectometer. Statistical evaluation of results based on comparisons of 8 competitive cleaners is documented. Curves showing performance vs concentration of cleaners are given.
Reishi immuno‐modulation protein induces interleukin‐2 expression via protein kinase‐dependent signaling pathways within human T cells (2008)

Ganoderma lucidum, a medicinal fungus is thought to possess and enhance a variety of human immune functions. An immuno-modulatory protein, Ling Zhi-8 (LZ-8) isolated from G. lucidum exhibited potent mitogenic effects upon human peripheral blood lymphocytes (PBL). However, LZ-8-mediated signal transduction in the regulation of interleukin-2 (IL-2) gene expression within human T cells is largely unknown. Here we cloned the LZ-8 gene of G. lucidum, and expressed the recombinant LZ-8 protein (rLZ-8) by means of a yeast Pichia pastoris protein expression system. We found that rLZ-8 induces IL-2 gene expression via the Src-family protein tyrosine kinase (PTK), via reactive oxygen species (ROS), and differential protein kinase-dependent pathways within human primary T cells and cultured Jurkat T cells. In essence, we have established the nature of the rLZ-8-mediated signal-transduction pathways, such as PTK/protein kinase C (PKC)/ROS, PTK/PLC/PKCalpha/ERK1/2, and PTK/PLC/PKCalpha/p38 pathways in the regulation of IL-2 gene expression within human T cells. Our current results of analyzing rLZ-8-mediated signal transduction in T cells might provide a potential application for rLZ-8 as a pharmacological immune-modulating agent.