gebhart/patrepeval huggingface dataset:
Electrophoretic and hydrodynamic properties of duplex ribonucleic acid molecules transcribed in vitro: evidence that A-tracts do not generate curvature in RNA (1991)

We have developed a T7 RNA polymerase based transcription system for the production of fully complementary RNA molecules (i.e., molecules capable of forming blunt-ended duplex species) as the direct products of transcription, thus rendering unnecessary the enzymatic removal of single-stranded ends. A combined gel electrophoretic and hydrodynamic analysis of a 180 bp double-stranded (ds) RNA molecule containing four A5-tracts in approximate phase coherence with the helix repeat provides no indication that the helix axis is curved, in sharp contrast to DNA molecules containing phased A-tracts. The electrophoretic behavior of dsRNA molecules reveals that their mobilities in nondenaturing acrylamide gels are approximately 10-20% lower than the corresponding mobilities of duplex DNA, in accord with earlier observations in the literature. Furthermore, the relative mobilities are only slightly modulated by gel concentration, the concentration of monovalent salt, or the presence of spermidine and/or Mg2+. The reduced mobilities are not caused by increased contour length, since direct hydrodynamic measurements using transient electric birefringence indicate that the average helix rise, h, of the dsRNA molecules examined in the current study is 2.8 +/- 0.1 A/bp. The reduced electrophoretic mobilities, extrapolated to zero acrylamide concentration, are consistent with the lower residual charge predicted for dsRNA by counterion condensation theory. Finally, birefringence measurements indicate that dsRNA is only marginally stiffer than DNA, with a persistence length of ca. 500-700 A.
Smoothing effect of GaAs/Al<i>x</i>Ga1−<i>x</i>As superlattices grown by metalorganic vapor phase epitaxy (1994)

GaAs/AlxGa1−xAs (x=0.5, 0.6, 1.0) superlattices used as buffer layers in high electron mobility transistors and photomultiplier devices can smooth out interface roughness. The mechanism of the smoothing effect has been discussed in detail. The initial stage of nucleation on the substrates has been clearly verified by examining the undulations of a 30 nm GaAs layer sandwiched between the substrate and the superlattice.
Übergangsmetallkomplexe, I. Olefin‐Komplexe des Nickels(0) (1966)

Abstract Bis‐[cyclooctadien‐(1.5)]‐nickel(0) ( 3 ), all‐trans ‐Cyclododecatrien‐(1.5.9)‐nickel(0) ( 12 ), Cyclooctatetraen‐nickel(0) ( 19 ) und Bis‐[cyclooctatetraen]‐nickel(0) ( 20 ) entstehen, wenn Nickelverbindungen in Gegenwart der überschüssigen Olefine mit Hilfe von metallorganischen Verbindungen reduziert werden. die kristallinen Komplexe lassen sich über Verdrängungsgleichgewichte zum Teil ineinander überführen. Bis‐[cyclooctadien‐(1.5)]‐nickel(0) reagiert mit Acetylaceton zu Cycloocten‐(4)‐yl‐(1)‐nickelacetylacetonat ( 4 ).
Synthesis and biochemical studies of various 8-substituted derivatives of guanosine cyclic-3',5' phosphate, inosine cyclic-3',5' phosphate, and xanthosine cyclic-3',5' phosphate (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and biochemical studies of various 8-substituted derivatives of guanosine cyclic-3',5' phosphate, inosine cyclic-3',5' phosphate, and xanthosine cyclic-3',5' phosphateJon P. Miller, Kay H. Boswell, Kei Muneyama, Lionel N. Simon, Roland K. Robins, and Dennis A. ShumanCite this: Biochemistry 1973, 12, 26, 5310–5319Publication Date (Print):December 1, 1973Publication History Published online1 May 2002Published inissue 1 December 1973https://doi.org/10.1021/bi00750a014RIGHTS & PERMISSIONSArticle Views236Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Synthesis of 4-Methacryloylmethyldiphenylsulphone and its Copolymerization (2010)

This paper presents the synthesis of two new compounds: 4-chloromethylphenylsulphone (4-CmDPhSu) and 4-methacryloylmethylphenylsulphone (4-McMDPhSu) which are derivatives of diphenylsuphone. Introduction of the methacryloyl group into 4-CmDPhSu transferred this compound into the vinyl monomer 4-McMDPhSu. This monomer was polymerized and copolymerized with the use of two types of initiators: a mixture containing benzoyl peroxide (BP) and N,N-dimethylaniline (DMA), as well as the photoinitiators Irgacure 651 or Darocur 1173. In further studies, its copolymers with methyl methacrylate were used. Their thermomechanical properties were studied.
The Selectivity of Visual Arrestin for Light-activated Phosphorhodopsin Is Controlled by Multiple Nonredundant Mechanisms (1998)

Arrestin plays an important role in quenching phototransduction via its ability to bind to the phosphorylated light-activated form of the visual receptor rhodopsin (P-Rh*). Remarkable selectivity of visual arrestin toward this functional form is determined by an elegant sequential multisite binding mechanism. Previous structure-function studies have suggested that the COOH-terminal region of arrestin (residues 356-404) is not directly involved in rhodopsin interaction, but instead plays a regulatory role. This region supports basal arrestin conformation and ensures arrestin's transition into a high affinity rhodopsin-binding state upon an encounter with P-Rh*. Overall, our results corroborate this hypothesis and identify three functional subregions (residues 361-368, 369-378, and 379-404) and individual amino acids involved in the control of arrestin stability and binding selectivity. Two of the most potent mutants, arrestin(1-378) and arrestin(F375A,V376A, F377A) belong to a novel class of constitutively active arrestins with high affinity for P-Rh*, dark P-Rh, and Rh* (but not dark Rh), in contrast to earlier constructed mutants arrestin(R175E) and arrestin(Delta2-16) with high affinity for light-activated forms only. The implications of these findings for the mechanism of arrestin-rhodopsin interaction are discussed in light of the recently determined crystal structure of arrestin.
Methods used to evaluate the immune protection factor of a sunscreen: advantages and disadvantages of different in vivo techniques. (2004)

Solar UV radiation (UVR) induces skin cancer in humans, a process partially mediated by UVR-induced immunosuppression. To help prevent skin cancer, sunscreens should prevent UVR-induced immunosuppression to a level that is comparable to their sun protection factor (SPF). There are no standardized protocols for determining the immune protection factor (IPF) of sunscreens or agreement on what degree of IPF is needed to fully preserve cutaneous immune function. Current in vivo approaches to this problem rely on sunscreens' ability to prevent localized UVR-induced suppression of contact hypersensitivity (CHS) and delayed-type hypersensitivity (DTH) responses, using either the induction or elicitation arms of these responses, with comprehensive controls. The induction arm of the CHS response is sensitive to a single suberythemal exposure of solar-simulated radiation (SSR), and allows for direct SPF and IPF comparisons. However, this approach requires a large number of volunteers and is extremely labor-intensive and time-consuming. The elicitation arm of the CHS or DTH response exploits prior sensitization to contact or recall antigens. Fewer volunteers are needed, but current protocols require repeat SSR exposure, which may invalidate comparison with SPF measures based on a single exposure, or erythemal doses, which may have systemic effects. Robust protocols for routinely assessing IPF are needed.
Formulation and Characterization of a Covalently Coated Magnetic Nanogel (2009)

The aim of this study was to develop a novel method to encapsulate magnetic nanoparticles (MNPs) with polymer via covalent bonding, in order to increase the magnetic nanoparticle stability and ease the synthesis process. In this technique, silane coated MNPs act as a template for polymerization of the monomer N-isopropylacrylamide, (NIPA) via radical polymerization. Transmission and scanning electron microscopy indicated the size of the original MNP was approximately 10 nm, the silane-coated MNP was 40 nm and the NIPA silane-coated MNP was 100 +/- 10 nm. Chemical composition and chemical state analysis of NIPA MNPs by FTIR and XPS showed that the MNPs were actually encapsulated by silane and NIPA. Furthermore, the magnetic properties of different layers on the MNP, analyzed by SQUID, indicated a decrease in saturation magnetization for each layer. The results demonstrate the feasibility of encapsulation of the MNP with NIPA by means of silane covalent bonding. Future work will investigate the phase transition and biocompatibility properties of the NIPA-coated MNP for drug delivery and tissue engineering applications.
Core Analysis (1939)

Core analysis is a recent development in the field of petroleum technology.The earliest work on this subject was done in connection with evaluating andplanning secondary oil recovery by water-flooding. Present-day analysis ofsands of flush fields requires new and independent interpretations of the dataprovided by cored material. Particular attention is being paid to thedevelopment of rapid, routine methods for measuring physical characteristics ofsandstone, such as permeability, porosity and grain size, as well as the sand's fluid content. Permeability may be defined as the fluid-passing capacity of a rock. For a sandstone to be permeable it must be possible to pass a measurablequantity of fluid through the material in a finite period of time. The commonunit of permeability is the darcy, which may be defined as the rate of viscousflow, in milliliters per second, of a fluid of one centipoise viscosity througha porous medium having a cross section of one square centimeter, under apressure gradient of one atmosphere (76.0 cm. Hg) per centimeter. 1 Forconvenience the subunit millidarcy, or one-thousandth darcy, is often used.Porosity is defined as the fluid-containing capacity of a rock and is usuallyexpressed as a percentage ratio of the total pore volume to the rock or bulkvolume. Since measurement of only the effective or communicating pore volume isoften made, porosities are distinguished as total or effective. Net effectiveporosity is defined as the net pore volume available for oil and gas. Oil andwater content of sand is measured and expressed either as the percentagesaturation of the total pores or of the bulk rock. The oil content may also beexpressed as the percentage saturation of the net effective pores. In connection with water-flooding, methods of core analysis were developed tofurnish data that could be used in determining the quantity of recoverable oil, and the probable rates at which various sands or divisions of a sand open tothe wells would take water or produce oil. In flush fields, the analytical dataare used to predict the productivity of a cored interval. T.P. 1024
Structural characterization of peptide hormone/receptor interactions by NMR spectroscopy (1999)

The structural characterization of peptide hormones and their interaction with G-protein (guanine nucleotide-binding regulatory protein) coupled receptors by high-resolution nmr is described. The general approaches utilized can be categorized into three different classes based on their target: the ligand, the receptor, and the ligand/receptor complex. Examples of these different approaches, aimed at facilitating the rational design of peptides and peptidomimetics with improved pharmacological profiles, based on work carried out in our own laboratory, are given. In the ligand-based approach, the high-resolution structures of bradykinin analogues allowing for the development of a structure-activity relationship for activation of the B1 receptor are described. Studies targeting the receptor are to a large extent theoretical, based on computational molecular modeling. However, experimentally based structural features provided by high-resolution nmr can be used to great advantage, providing insight into the mechanism of receptor function, as illustrated here with results from parathyroid hormone. A similar combination of theoretical methods, supplemented by high-resolution structures from nmr has been utilized to probe the formation and stabilization of the ligand/receptor complex both for parathyroid hormone and cholecystokinin. In each of these three approaches, the importance of well-designed peptide mimetics and accurate structural analysis by high-resolution nmr, will be highlighted.
Organic Light Emitting Devices and Materials Integrated with Active Matrix Backplanes for Flexible Displays (2006)

The following paper details the development of a new phosphorescent emitting dopant molecule for organic light emitting diodes (OLEDs). A systematic series of heteroleptic tris-cyclometallated iridium compounds were fabricated. Of the molecules, the fac- Ir(dfppy)(dfppz)2 compound had the blue-est emission with the highest quantum efficiency. Phosphorescent emitting OLEDs (PhOLED) were fabricated and properties measured. The emitting dopant was integrated into a device structure and the properties measured as a function of doping concentration. The device efficiency is 20 lm/W at 100 cd/m2 and a peak emission of 498 nm. The Army's Flexible Display Center (FDC) has fabricated thin film transistors on a rigid opaque substrate that make up an active matrix (AM) backplane. ARL's OLEDs are being integrated with the AM backplanes to demonstrate high performance emissive test demonstrator displays with a 1.1" diag.
Luminescence Properties of Eu[sup 2+]-Doped Ca-α-SiAlON Synthesized by Spark Plasma Sintering (2010)

Yellow light-emitting -doped phosphors with compositions of were successfully prepared by spark plasma sintering (SPS), and their luminescence properties were investigated. The phosphors absorbed in the UV–blue visible light region and showed a strong yellow-orange emission band centered at 565 nm. The influences of Ca content, Eu doping concentration, synthesis temperature, and post-heat-treatment on the luminescence performance of phosphors were investigated. The optimization of SPS and subsequent postannealing yields the yellow phosphor with an emission intensity comparable to the commercial yellow phosphor under blue light excitation.
Dynamic group key authentication mechanism for data sharing in network (2014)

In the network data sharing is an important functionality. In many organizations data owners store their data into the storage server which can certainly share data with other followers (users). Earlier approaches either unreasonably expose the uniqueness of a data owner to the untrusted server or any unexclusive vouchers, or innovate substantial expenses on confirmation metadata to preserve concealment. In the proposed system, group manager is introduced and takes charge of user registration, and enlightening the real uniqueness of a dispute data proprietor. Group manager will generate a key and provide to the user, who want to access the data from the storage server. Consequently proposed method reduces the computation overhead and provides high performance due to revoke verification procedure.
Molecular beam epitaxy of low defect density (<b>⩽</b>1×104 cm−2) ZnSSe on GaAs (1996)

We study the growth of pseudomorphic ZnSSe layers on GaAs. The dependence of the epilayer quality on Zn exposure to the GaAs surface is investigated. Zn treatment prior to the ZnSe buffer growth on the As-rich GaAs surface results in the lowest defect density. Transmission electron microscopy studies show that an atomic scale smooth interface is formed. Based on the etch pit density and photoluminescence image analysis, ZnSSe layers with defect density ≤1×104 cm−2 can be reproducibly obtained.
A Study of two Types of Vomiting Associated with Acetonuria (1928)

Lecturer in Chemistry in
Feasibility of ALOS2 PALSAR2 Offset-Based Phase Unwrapping of SAR Interferogram in Large and Complex Surface Deformations (2018)

The interferometric synthetic aperture radar (InSAR) is a well-known tool for mapping ground surface deformations with centimeter precision, and is much better than that used in the offset tracking method. However, the InSAR method has difficulties in precisely measuring large deformation signals because the phase unwrapping can include severe errors in the case of large and complex deformations. To overcome this drawback, an offset-based unwrapping strategy was proposed. However, this strategy has almost never been used for the unwrapping approach because the accuracy of offset measurement is much lower than that of InSAR measurement. As the spatial resolution of the SAR image becomes more precise, the offset measurement accuracy increases. Specifically, the L-band ALOS2 PALSAR2 sensor has much higher offset measurement accuracy due to its higher spatial resolution. In this paper, the feasibility of the unwrapping of a PALSAR-2 interferometric phase with large surface deformation signals, using an offset map, is proved. This validation of offset-based unwrapping was performed using two ALOS2 PALSAR2 coseismic pairs in the 2016 Kumamoto earthquake where large deformations of more than 200 cm occurred. The offset-based unwrapping was more successful than traditional unwrapping. The root-mean square errors of offset-based unwrapping using GPS in situ data were about 1.96 and 1.90 cm in the ascending and descending pairs, respectively. The validation results showed that the ALOS2 PALSAR2 offset-based unwrapping enables us to measure complex and large deformation signals accurately. Precise measurements in high-gradient and high-decorrelated deformation areas would be helpful to better understand geological mechanisms.
Design of 28nm FD-SOI CMOS 800MS/s SAR ADC for wireless applications (2016)

As user expectations for higher bandwidth continue to rise, new techniques are required. One such is the massive-Multiple Input Multiple Output (MIMO), building on dozens or hundreds of antennas all having their own antenna. Making compact, low cost transceivers then becomes essential. Silicon technology fulfils the cost while suffering in terms of performance which needs to be compensated for by active pre-distortion which require an Analog-to-Digital Converter (ADC). This converter must have low power consumption, small footprint and achieve high sample rates in order to be useful. This work tries to fulfil these demands by implementing a Successive-Approximation- Register (SAR) Analog-to-Digital Converter (ADC) in a 28nm Fully Depleted Silicon on Insulator (FD-SOI) Complementary Metal-Oxide Semiconductor (CMOS) process. The converter has been implemented based on the principle of alternating comparators in combination with a redundantly scaled Capacitive Digital-to-Analog Converter (CDAC) that help increase the operation speed. The implementation also includes additional circuitry in order to support testing of the circuit. The implemented ADC shows an SNDR = 38.4 dB at a sample rate of 800MS/s. The converter consumes 1.1mW of power while doing this which results in a FoMW = 20.3 fJ/conversion step. This Figure of Merit (FoM) is among the lowest reported for high speed ADC.
Alterations of Chromosome Arms 1p and 19q as Predictors of Survival in Oligodendrogliomas, Astrocytomas, and Mixed Oligoastrocytomas (2000)

Combined loss of 1p and 19q is a statistically significant predictor of prolonged survival in patients with pure oligodendroglioma, independent of tumor grade. Given the lack of this association in patients with astrocytic neoplasms and the previously demonstrated chemosensitivity of oligodendrogliomas, a combined approach of histologic and genotypic assessment could potentially improve existing strategies for patient stratification and management.
Investigation of ejector re-compression absorption refrigeration cycle (1999)

This thesis describes a theoretical and experimental investigation of the ejector re-compression lithium bromide absorption refrigeration cycle. In this novel cycle, a steam ejector is used to enhance the concentration process by compressing the vapour to a state that it can be used to re-heat the solution from where it was evolved. Since this cycle recovers the heat otherwise wasted in a conventional absorption cycle, the energy performance of the cycle is improved. The theoretical study shows that the improvement of the efficiency is proportional to the performance of the steam ejector. A COP of 1.013 was achieved from the experiment in this investigation.\n\nThe novel cycle does not only improve the energy efficiency but also avoids the corrosion that will happen when high temperature heat sources are used to drive a lithium bromide absorption refrigerator. The steam ejector in the novel cycle acts as an efficient temperature converter in acceptance of different temperature heat sources, which reduces the energy loss when the temperature difference between the solution and the heat source is big. Therefore, the solution temperature can be set to a low level while the heat source temperature is high. This is significant to avoid the corrosion of lithium bromide solution at high temperature. Furthermore, the construction of the machine based on the novel cycle is simpler than that based on the conventional double-effect cycle. This refrigerator will be more reliable and have a lower initial capital cost.\n\nThe cycle was investigated comprehensively in this thesis. In the theoretical study, a mathematical model for this novel cycle was established. The theoretical study reveals the operation characteristics and the factors that affect the energy efficiency of the cycle as well as how to design a refrigerator based on the novel cycle. In the experimental study, a concept-approved refrigerator was manufactured and tested. The part-load performance of the novel cycle was investigated from the experiment. The theoretical results had a good agreement with the experimental ones.\n\n\nNB. This ethesis has been created by scanning the typescript original and contains some inaccuracies. In case of difficulty, please refer to the original text.
LISZT AS LIEDER COMPOSER (1917)

Journal Article LISZT AS LIEDER COMPOSER Get access EDWIN HUGHES EDWIN HUGHES Search for other works by this author on: Oxford Academic Google Scholar The Musical Quarterly, Volume III, Issue 3, July 1917, Pages 390–409, https://doi.org/10.1093/mq/III.3.390 Published: 01 July 1917
ChemInform Abstract: Low Micromolar Inhibitors of Galectin‐3 Based on 3′‐Derivatization of N‐Acetyllactosamine. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.