gebhart/patrepeval huggingface dataset:
Genetic Algorithms As an Approach to Configuration and Topology Design (1993)

Abstract The Genetic Algorithm, a search and optimization technique based on the theory of natural selection, is applied to problems of structural topology optimization. Given a structure’s boundary conditions and maximum allowable design domain, a discretized design representation is created. Populations of genetic algorithm “chromosomes” are then mapped into the design representation, creating potentially optimal structure topologies. Utilizing genetics-based operators such as crossover and mutation, generations of increasingly-desirable structure topologies are created. In this paper, the use of the genetic algorithm (GA) in structural topology optimization is presented. An overview of the genetic algorithm will describe the genetics-based representations and operators used in a typical genetic algorithm search. After defining topology optimization and its relation to the broader area of structural optimization, a review of previous research in GA-based and non-GA-based structural optimization is provided. The design representations, and methods for mapping genetic algorithm “chromosomes” into structure topology representations, are then detailed. Several examples of genetic algorithm-based structural topology optimization are provided: we address the optimization of beam cross-section topologies and cantilevered plate topologies, and we also investigate efficient techniques for using finite element analysis in a genetic algorithm-based search. Finally, a description of potential future work in genetic algorithm-based structural topology optimization is offered.
Data mining for fuzzy diagnosis systems in LTE networks (2015)

The recent developments in cellular networks, along with the increase in services, users and the demand of high quality have raised the Operational Expenditure (OPEX). Self-Organizing Networks (SON) are the solution to reduce these costs. Within SON, self-healing is the functionality that aims to automatically solve problems in the radio access network, at the same time reducing the downtime and the impact on the user experience. Self-healing comprises four main functions: fault detection, root cause analysis, fault compensation and recovery. To perform the root cause analysis (also known as diagnosis), Knowledge-Based Systems (KBS) are commonly used, such as fuzzy logic. In this paper, a novel method for extracting the Knowledge Base for a KBS from solved troubleshooting cases is proposed. This method is based on data mining techniques as opposed to the manual techniques currently used. The data mining problem of extracting knowledge out of LTE troubleshooting information can be considered a Big Data problem. Therefore, the proposed method has been designed so it can be easily scaled up to process a large volume of data with relatively low resources, as opposed to other existing algorithms. Tests show the feasibility and good results obtained by the diagnosis system created by the proposed methodology in LTE networks.
IL-23 Is Required for the Development of Severe Egg-Induced Immunopathology in Schistosomiasis and for Lesional Expression of IL-17 (2008)

In infection with the trematode helminth Schistosoma mansoni, the severity of CD4 T cell-mediated hepatic granulomatous and fibrosing inflammation against parasite eggs varies considerably in humans and among mouse strains. In mice, either the natural high pathology, or high pathology induced by concomitant immunization with schistosome egg Ags (SEA) in CFA (SEA/CFA), results from a failure to contain a net proinflammatory cytokine environment. We previously demonstrated that the induction of severe immunopathology was dependent on the IL-12/IL-23 common p40 subunit, and correlated with an increase in IL-17, thus implying IL-23 in the pathogenesis. We now show that mice lacking the IL-23-specific subunit p19 are impaired in developing severe immunopathology following immunization with SEA/CFA, which is associated with a marked drop of IL-17 in the granulomas, but not in the draining mesenteric lymph nodes, and with a markedly suppressed SEA-specific IFN-gamma response regulated by a striking increase in IL-10. The granulomas are characterized by a significant reduction in Gr-1(+) cell recruitment and by alternative macrophage activation. Taken together, these results demonstrate that IL-23 per se is not necessary for the generation of IL-17-producing T cells, but is essential for the development of severe schistosome egg-induced immunopathology, and its absence cannot be overcome with other possible compensatory mechanisms.
Video-Based Sign Language Recognition Without Temporal Segmentation (2018)

Millions of hearing impaired people around the world routinely use some variants of sign languages to communicate, thus the automatic translation of a sign language is meaningful and important. Currently, there are two sub-problems in Sign Language Recognition (SLR), i.e., isolated SLR that recognizes word by word and continuous SLR that translates entire sentences. Existing continuous SLR methods typically utilize isolated SLRs as building blocks, with an extra layer of preprocessing (temporal segmentation) and another layer of post-processing (sentence synthesis). Unfortunately, temporal segmentation itself is non-trivial and inevitably propagates errors into subsequent steps. Worse still, isolated SLR methods typically require strenuous labeling of each word separately in a sentence, severely limiting the amount of attainable training data. To address these challenges, we propose a novel continuous sign recognition framework, the Hierarchical Attention Network with Latent Space (LS-HAN), which eliminates the preprocessing of temporal segmentation. The proposed LS-HAN consists of three components: a two-stream Convolutional Neural Network (CNN) for video feature representation generation, a Latent Space (LS) for semantic gap bridging, and a Hierarchical Attention Network (HAN) for latent space based recognition. Experiments are carried out on two large scale datasets. Experimental results demonstrate the effectiveness of the proposed framework.
Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat (1996)

We have recently shown that it is not possible to restore euthyroidism completely in all tissues of thyroidectomized rats infused with T4 alone. The present study was undertaken to determine whether this is achieved when T3 is added to the continuous sc infusion of T4. Thyroidectomized rats were infused with placebo or T4 (0.80 and 0.90 μg/100 g BW · day), alone or in combination with T3 (0.10, 0.15, or 0.20 μg/100 g BW · day). Placebo- infused intact rats served as euthyroid controls. Plasma and 12 tissues were obtained after 12 days of infusion. Plasma TSH and plasma and tissue T4 and T3 were determined by RIA. Iodothyronine deiodinase activities were assayed using cerebral cortex, pituitary, brown adipose tissue, liver, and lung. Circulating and tissue T4 levels were normal in all the groups infused with thyroid hormones. On the contrary, T3 in plasma and most tissues and plasma TSH only reached normal levels when T3 was added to the T4 infusion. The combination of 0.9 μg T4 and 0.15 μg T3/100 g BW-day resulted in normal T4 and T3 concentrations in plasma and all tissues as well as normal circulating TSH and normal or near-normal 5'-deiodinase activities. Combined replacement therapy with T4 and T3 (in proportions similar to those secreted by the normal rat thyroid) completely restored euthyroidism in thyroidectomized rats at much lower doses of T4 than those needed to normalize T3 in most tissues when T4 alone was used. If pertinent to man, these results might well justify a change in the current therapy for hypothyroidism.
Synthesis and Characterization of Iron(II) Complexes with Tetradentate Diiminodiphosphine or Diaminodiphosphine Ligands as Precatalysts for the Hydrogenation of Acetophenone (2008)

Six complexes of the type trans-[Fe(NCMe)2(P-N-N-P)]X2 (X = BF4(-), B{Ar(f)}4(-)) (Ar(f) = 3,5-(CF3)2C6H3) containing diiminodiphosphine ligands and the complexes trans-[Fe(NCMe)2(P-NH-NH-P)][BF4]2 with a diaminodiphosphine ligand were obtained by the reaction of Fe(II) salts with achiral and chiral P-N-N-P or P-NH-NH-P ligands, respectively, in acetonitrile at ambient temperature. The P-N-N-P ligands are derived from reaction of ortho-diphenylphosphinobenzaldehyde with the diamines 1,2-ethylenediamine, 1,3-propylenediamine, (S,S)-1,2-disopropyl-1,2-diaminoethane, and (R,R)-1,2-diphenyl-1,2-diaminoethane. Some complexes could also be obtained for the first time in a one-pot template synthesis under mild reaction conditions. Single crystal X-ray diffraction studies of the complexes revealed a trans distorted octahedral structure around the iron. The iPr or Ph substituents on the diamine were found to be axial in the five-membered Fe-N-CHR-CHR-N- ring of the chiral P-N-N-P ligands. A steric clash between the imine hydrogen and the substituent probably determines this stereochemistry. The diaminodiphosphine complex has longer Fe-N and Fe-P bonds than the analogous diiminodiphosphine complex. The new iron compounds were used as precatalysts for the hydrogenation of acetophenone. The complexes without axial substituents on the diamine had moderate catalytic activity while that with axial Ph substituents had low activity but fair (61%) enantioselectivity for the asymmetric hydrogenation of acetophenone. The fact that the diaminodiphosphine complex has a slightly higher activity than the corresponding diiminodiphosphine complex suggests that hydrogenation of the imine groups in the P-N-N-P ligand may be important for catalyst activation. Evidence is provided, including the first density-functional theory calculations on iron-catalyzed outer-sphere ketone hydrogenation, that the mechanism is similar to that of ruthenium analogues.
Narrative Review: Statin-Related Myopathy (2009)

Statin-related myopathy is a clinically important cause of statin intolerance and discontinuation. The spectrum of statin-related myopathy ranges from common but clinically benign myalgia to rare but life-threatening rhabdomyolysis. Observational studies suggest that myalgia can occur in up to 10% of persons prescribed statins, whereas rhabdomyolysis continues to be rare. The mechanisms of statin-related myopathy are unclear. Options for managing statin myopathy include statin switching, particularly to fluvastatin or low-dose rosuvastatin; nondaily dosing regimens; nonstatin alternatives, such as ezetimibe and bile acid-binding resins; and coenzyme Q10 supplementation. Few of these strategies have high-quality evidence supporting them. Because statin-related myopathy will probably become more common with greater numbers of persons starting high-dose statin therapy and the increasing stringency of low-density lipoprotein cholesterol level targets, research to better identify patients at risk for statin myopathy and to evaluate management strategies for statin-related myopathy is warranted.
MAMMOTH: A massive-scale emulation platform for Internet of Things (2012)

Internet of Things (IoT) is increasingly used in a plethora of fields to enable radically new ways for various purposes, ranging from monitoring the environment to enhancing the wellbeing of human life. With the ever-increasing size of such networks, it is fundamental to understand the issues that come with scaling on different networking layers. A cost-efficient approach to examine large-scale networks is to use simulators or emulators to test the infrastructure and its ability to support the desired applications. In this paper, we investigate and compare the currently available simulation/emulation software. We found out that the current solutions are mostly appropriate for small- and medium-scale emulation, however they are not suitable for large-scale testing that reaches millions of node running concurrently. We then propose a large-scale IoT emulator called MAMMotH and present a brief overview of its design. Finally we discuss some of the current issues and future directions, e.g. radio link simulation.
Genetic Algorithm based Automated Calibration Tool for Numerical Selective Catalytic Reduction (SCR) Models (2009)

<div class="htmlview paragraph">An automated process was developed for the calibration of numerical aftertreatment models. The chemical kinetic mechanism examined in this case was part of a simplified SCR model. The process adopted for calibrating the SCR model was based on a micro-population multi-objective genetic algorithm. The algorithm developed was used to calibrate the SCR model using data derived from another, more detailed model to ensure that the evaluation focused only on the effectiveness of the calibration process and was not affected by issues of experimental inaccuracies or details of the model chemistry involved.</div>
B-cell subpopulations in humans and their differential susceptibility to depletion with anti-CD20 monoclonal antibodies (2013)

In humans, different B-cell subpopulations can be distinguished in peripheral blood and other tissues on the basis of differential expression of various surface markers. These different subsets correspond to different stages of maturation, activation and differentiation. B-cell depletion therapy based on rituximab, an anti-CD20 mAb, is widely used in the treatment of various malignant and autoimmune diseases. Rituximab induces a very significant depletion of B-cell subpopulations in the peripheral blood usually for a period of 6 to 9 months after one cycle of therapy. Cells detected circulating during depletion are mainly CD20 negative plasmablasts. Data on depletion of CD20-expressing B cells in solid tissues are limited but show that depletion is significant but not complete, with bone marrow and spleen being more easily depleted than lymph nodes. Factors influencing depletion are thought to include not only the total drug dose administered and distribution into various tissues, but also B-cell intrinsic and microenvironment factors influencing recruitment of effector mechanisms and antigen and effector modulation. Available studies show that the degree of depletion varies between individuals, even if treated with the same dose, but that it tends to be consistent in the same individual. This suggests that individual factors are important in determining the final extent of depletion.
Nitroparacetamol exhibits anti‐inflammatory and anti‐nociceptive activity (2000)

Nitroparacetamol (NCX-701) is a newly synthesized nitric oxide-releasing derivative of paracetamol. Following i.p. administration, nitroparacetamol inhibits carrageenan-induced hindpaw oedema formation (ED(50), 169.4 micromol kg(-1)) and mechanical hyperalgesia (ED(50), 156 micromol kg(-1)) in the rat. In contrast, the parent compound, paracetamol, exhibits no significant anti-oedema activity in this model (ED(50)>1986 micromol kg(-1), i.p. ) and is markedly less potent than nitroparacetamol as an inhibitor of carrageenan-mediated hyperalgesia (ED(50), 411.6 micromol kg(-1), i.p.). In a second model of nociception (inhibition of acetic acid induced abdominal constrictions in the mouse), nitroparacetamol administered orally (ED(50), 24.8 micromol kg(-1)), was again considerably more potent than paracetamol (ED(50), 506 micromol kg(-1), p.o.). Thus, compared with paracetamol, nitroparacetamol not only exhibits augmented antinociceptive activity in both rat and mouse but, intriguingly, is also anti-inflammatory over a similar dose range.
A new scheme for touchless fingerprint recognition system (2005)

Fingerprint-based recognition systems are widely used in the field of biometrics. Most of the fingerprint sensors developed so far acquire fingerprint images through the surface of a solid plate, which degrades the recognition performance due to deformations. These deformations are caused by the pressure of the physical contact that is costly and hard to estimate. A touchless fingerprint recognition system is devised using a camera sensor to resolve this problem. However, this system raises some new problems, such as defocusing, low ridge-valley contrast, 3D-to-2D mapping, and so forth. Adequate solutions are discussed by introducing modified steps to the algorithm. Our proposed system is compared with a primitive touchless sensor with no manipulation and the algorithm of the preceding touch-based system. Future work is suggested.
Phase II trial of docetaxel: a new, highly effective antineoplastic agent in the management of patients with anthracycline-resistant metastatic breast cancer. (1995)

Docetaxel has the highest reported antitumor activity in anthracycline-resistant MBC. High objective response rates were seen in patients with visceral-dominant involvement, multiple metastatic sites, or extensive previous therapy. Docetaxel is associated with severe but reversible neutropenia, asthenia, and cumulative dose-related fluid retention. Dexamethasone decreased the frequency and severity of skin toxicity and appeared to ameliorate fluid retention.
Mode stabilization method for superstructure-grating DBR lasers (1998)

A wavelength stabilization method for widely tunable superstructure-grating (SSG) distributed Bragg reflector (DBR) laser is described. The output characteristics under tuning are studied theoretically and experimentally. It is found that peak reflectivity states, in which the lasing mode is just aligned with the reflection peaks of both DBR's, are obtained at saddle points in the output characteristics while changing the two SSG-DBR currents. Based on these results, a method for the Bragg frequency control of the two SSG-DBRs is proposed. The feedback control circuit keeps the lasing mode at a peak reflectivity state, and it suppresses mode hopping. Additionally, the oscillation mode is locked to arbitrary reference wavelengths of an optical filter. Stabilization at 200 GHz (1.6 nm)-spaced 16 wavelengths was achieved within the wide tuning range of the SSG-DBR laser. Control was maintained under a laser temperature variation of /spl plusmn/5/spl deg/C as a result of the Bragg frequency control of the two DBR's.
A New Code for Galileo (1988)

Over the past six to eight years, an extensive research effort was conducted to investigate advanced coding techniques which promised to yield more coding gain than is available with current NASA standard codes. The delay in Galileo's launch due to the temporary suspension of the shuttle program provided the Galileo project with an opportunity to evaluate the possibility of including some version of the advanced codes as a mission enhancement option. A study was initiated last summer to determine if substantial coding gain was feasible for Galileo and, is so, to recommend a suitable experimental code for use as a switchable alternative to the current NASA-standard code. The Galileo experimental code study resulted in the selection of a code with constant length 15 and rate 1/4. The code parameters were chosen to optimize performance within cost and risk constraints consistent with retrofitting the new code into the existing Galileo system design and launch schedule. The particular code was recommended after a very limited search among good codes with the chosen parameters. It will theoretically yield about 1.5 dB enhancement under idealizing assumptions relative to the current NASA-standard code at Galileo's desired bit error rates. This ideal predicted gain includes enough cushion to meet the project's target of at least 1 dB enhancement under real, non-ideal conditions.
Taxonomic Status of Micrococcus varians Migula 1900 and Designation of the Neotype Strain (1972)

An amended description of Micrococcus varians Migula 1900 is given on the basis of a study of 20 strains. CCM 884 (= ATCC 15306 = NCTC 7564) is designated as the neotype strain of M. varians. Staphylococcus lactis Shaw et al. 1951 is a later objective synonym and Microccus pulcher Müller 1961 is a later subjective synonym of M. varians Migula 1900.
The Ret Finger Protein Inhibits Signaling Mediated by the Noncanonical and Canonical IκB Kinase Family Members (2006)

IFN regulatory factor-3 is a transcription factor that is required for the rapid induction of type I IFNs in the innate antiviral response. Two noncanonical IkappaB kinase (IKK) family members, IKKepsilon and TRAF family-associated NF-kappaB activator-binding kinase-1, have been shown to phosphorylate IFN regulatory factor-3 and are critically involved in virus-triggered and TLR3-mediated signaling leading to induction of type I IFNs. In yeast two-hybrid screens for potential IKKepsilon-interacting proteins, we identified Ret finger protein (RFP) as an IKKepsilon-interacting protein. Coimmunoprecipitation experiments indicated that RFP interacted with IKKepsilon and TRAF family-associated NF-kappaB activator-binding kinase-1 as well as the two canonical IKK family members, IKKbeta and IKKalpha. RFP inhibited activation of the IFN-stimulated response element and/or NF-kappaB mediated by the IKK family members and triggered by TNF, IL-1, polyinosinic-polycytidylic acid (ligand for TLR3), and viral infection. Moreover, knockdown of RFP expression by RNA interference-enhanced activation of IFN-stimulated response element and/or NF-kappaB triggered by polyinosinic-polycytidylic acid, TNF, and IL-1. Taken together, our findings suggest that RFP negatively regulates signaling involved in the antiviral response and inflammation by targeting the IKKs.
Wait-free queues with multiple enqueuers and dequeuers (2011)

The queue data structure is fundamental and ubiquitous. Lock-free versions of the queue are well known. However, an important open question is whether practical wait-free queues exist. Until now, only versions with limited concurrency were proposed. In this paper we provide a design for a practical wait-free queue. Our construction is based on the highly efficient lock-free queue of Michael and Scott. To achieve wait-freedom, we employ a priority-based helping scheme in which faster threads help the slower peers to complete their pending operations. We have implemented our scheme on multicore machines and present performance measurements comparing our implementation with that of Michael and Scott in several system configurations.
Studies on the environment structure of natural nidi and epidemic areas of hemorrhagic fever with renal syndrome in China. (1994)

The environment structure of natural nidi and epidemic areas of hemorrhagic fever with renal syndrome (HFRS) possesses characteristics of topography, hydrology, climate, soil, vegetation, and animals. The natural nidi and epidemic areas of HFRS are distributed mainly in plain and hilly regions under 500 meters above the sea level; in plentiful-water zones and transitional zones; in temperate zone and subtropical zone of the eastern monsoon region; in the abundant-aluminum soil region and the sial soil region; in the eastern China damp forest region (agricultural districts and northeast forest districts); in the eastern Asia dampness-preferring animal geographic region. Apodemus agrarius and Rattus norvegicus are the thriving animal population, predominant species or common species as well as the main reservoir hosts and sources of infection in the natural nidi and epidemic areas of HFRS.