gebhart/patrepeval huggingface dataset:
NASA's next generation all-digital deep space network breadboard receiver (1993)

This work describes the breadboard advanced receiver (called ARX) that is currently being built for use in NASA's deep space network (DSN). This receiver has unique requirements in having to operate with very weak signals from deep space probes and provide high-quality telemetry and tracking data. The hybrid analog/digital receiver performs multiple functions, including carrier, subcarrier, and symbol synchronization. Tracking can be achieved for either residual, suppressed or hybrid carriers and for both sinusoidal and square wave subcarriers. System requirements are specified, and a functional description of the ARX is presented. The various digital signal processing (DSP) algorithms used are illustrated with block diagrams. Other functions, such as time tagged Doppler extraction and monitor/control, are also discussed, including acquisition algorithms and lock detection schemes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Multivariate Correlation of Higher Harmonics for Heart Rate Remote Measurement Using UWB Impulse Radar (2019)

Ultra wideband impulse (UWB) radars are getting much attention in the application of remote sensing of heart rate. UWB radar measures the heart rate by mean of the motion of thorax in the heartbeat activities. However, the signal of heartbeat is usually much smaller than the harmonics signal of respiration, then be easily perturbed. Thus, this paper proposed a multivariate correlation method (MCM) to improve the signal-to-noise ratio (SNR) of the heartbeat. The MCM is applied in the bandwidth of higher harmonics rather than the fundamental of heart rate to minimize the affection of the respiration signal. The experiments showed that the second harmonic of heart rate is good at minimizing the affection of the respiration signal, and the MCM is efficient to improve the SNR about 83.7 dB than the continuous wavelet transform method. The heart rate could be estimated with an average error of 2.54% compared with a referenced photoplethysmography sensor.
Evaluation of Carrier-Based PWM Methods for Multi-level Inverters (2007)

Carrier-based methods have been used widely for switching of multilevel inverters due to their simplicity, flexibility and reduced computational requirements compared to space vector modulation (SVM). Several multi-carrier modulation methods with miscellaneous properties have been already known. The paper also proposes another three new multi-carrier techniques being more efficient for high-power inverter applications. While evaluating and comparing these new methods with all basic methods, such as PS, PD, POD and APOD through measures like THD, WTHD, WTHDO, switching losses and DC bus utilization, the paper shows their advantages for applications of diode-clamped and cascade multi-level topologies by simulation results. The validity of obtained results is approved by experimental results.
GLOBALIZAÇÃO E DIVERSIDADE CULTURAL: o caso do Manguebeat na música brasileira contemporânea (2003)

Este artigo discute um dos movimentos culturais mais importantes da ultima decada na musica brasileira: o movimento Manguebeat, surgido no Recife. Esse movimento musical e cultural rompeu as fronteiras regionais e seus produtos foram vendidos em varias partes do Brasil. Alem disso, eles foram submetidos a um processo de comercializacao sem precedentes na historia da musica popular produzida em Pernambuco. O movimento colocou o estado como um dos polos mais importantes na producao de musica direcionada para o publico jovem. Outra questao discutida e o debate sobre o potencial de destruicao das culturas locais pela industria cultural globalizada dos grandes conglomerados transnacionais. O contato com os produtos dessa industria levaria a perda daquelas culturas. No entanto, este artigo traz para a discussao um caso em que a cultura local consegue desafiar a centralidade dos produtos globais e reforcar o mercado e as culturas locais a partir da hibidrizacao com as influencias externas. Pode-se observar uma combinacao da cultura local com o repertorio internacional, onde a alianca com grandes gravadoras nao se apresenta como um ameaca para a perda da identidade.
Formation and Properties of Stabilized Aluminum Nanoparticles (2009)

The wet-chemical synthesis of aluminum nanoparticles was investigated systematically by using dimethylethylamine alane and 1-methylpyrrolidine alane as precursors and molecules with one or a pair of carboxylic acid groups as surface passivation agents. Dimethylethylamine alane was more reactive, capable of yielding well-defined and dispersed aluminum nanoparticles. 1-Methylpyrrolidine alane was less reactive and more complex in the catalytic decomposition reaction, for which various experimental parameters and conditions were used and evaluated. The results suggested that the passivation agent played dual roles of trapping aluminum particles to keep them nanoscale during the alane decomposition and protecting the aluminum nanoparticles postproduction from surface oxidation and that an appropriate balance between the rate of alane decomposition (depending more sensitively on the reaction temperature) and the timing in the introduction of the passivation agent into the reaction mixture was critical to the desired product mixes and/or morphologies. Some fundamental and technical issues on the alane decomposition and the protection of the resulting aluminum nanoparticles are discussed.
One-pot Borohydride Synthesis of Magnetically Modified Lepidocrocite (2005)

Abstract The one-pot borohydride treatment of a Fe(NO3)3/CoCl2 aqueous solution results in an inorganic magnetic nanocomposite γ-FeOOH/Co where the properties of the layered support are combined with those of the cobalt nanoparticles.
Baby Care Products: Possible Sources of Infant Phthalate Exposure (2008)

Phthalate exposure is widespread and variable in infants. Infant exposure to lotion, powder, and shampoo were significantly associated with increased urinary concentrations of monoethyl phthalate, monomethyl phthalate, and monoisobutyl phthalate, and associations increased with the number of products used. This association was strongest in young infants, who may be more vulnerable to developmental and reproductive toxicity of phthalates given their immature metabolic system capability and increased dosage per unit body surface area.
GM-CSF mediates autoimmunity by enhancing IL-6–dependent Th17 cell development and survival (2008)

Granulocyte macrophage-colony stimulating factor (GM-CSF) is critically involved in development of organ-related autoimmune inflammatory diseases including experimental allergic encephalitis and collagen-induced arthritis. Roles of GM-CSF in the initiation and in the effector phase of the autoimmune response have been proposed. Our study was designed to investigate the mechanisms of GM-CSF in autoimmunity using a model of autoimmune heart inflammatory disease (myocarditis). The pathological sequel after immunization with heart myosin has been shown previously to depend on IL-1, IL-6, IL-23, and IL-17. We found that innate GM-CSF was critical for IL-6 and IL-23 responses by dendritic cells and generation of pathological Th17 cells in vivo. Moreover, GM-CSF promoted autoimmunity by enhancing IL-6-dependent survival of antigen specific CD4(+) T cells. These results suggest a novel role for GM-CSF in promoting generation and maintenance of Th17 cells by regulation of IL-6 and IL-23 in vivo.
Raf Kinase Inhibitor Protein Interacts with NF-κB-Inducing Kinase and TAK1 and Inhibits NF-κB Activation (2001)

The Raf kinase inhibitor protein (RKIP) acts as a negative regulator of the mitogen-activated protein (MAP) kinase (MAPK) cascade initiated by Raf-1. RKIP inhibits the phosphorylation of MAP/extracellular signal-regulated kinase 1 (MEK1) by Raf-1 by disrupting the interaction between these two kinases. We show here that RKIP also antagonizes the signal transduction pathways that mediate the activation of the transcription factor nuclear factor kappa B (NF-kappaB) in response to stimulation with tumor necrosis factor alpha (TNF-alpha) or interleukin 1 beta. Modulation of RKIP expression levels affected NF-kappaB signaling independent of the MAPK pathway. Genetic epistasis analysis involving the ectopic expression of kinases acting in the NF-kappaB pathway indicated that RKIP acts upstream of the kinase complex that mediates the phosphorylation and inactivation of the inhibitor of NF-kappaB (IkappaB). In vitro kinase assays showed that RKIP antagonizes the activation of the IkappaB kinase (IKK) activity elicited by TNF-alpha. RKIP physically interacted with four kinases of the NF-kappaB activation pathway, NF-kappaB-inducing kinase, transforming growth factor beta-activated kinase 1, IKKalpha, and IKKbeta. This mode of action bears striking similarities to the interactions of RKIP with Raf-1 and MEK1 in the MAPK pathway. Emerging data from diverse organisms suggest that RKIP and RKIP-related proteins represent a new and evolutionarily highly conserved family of protein kinase regulators. Since the MAPK and NF-kappaB pathways have physiologically distinct roles, the function of RKIP may be, in part, to coordinate the regulation of these pathways.
Temperature: The “Ignored” Factor at the NanoBio Interface (2013)

Upon incorporation of nanoparticles (NPs) into the body, they are exposed to biological fluids, and their interaction with the dissolved biomolecules leads to the formation of the so-called protein corona on the surface of the NPs. The composition of the corona plays a crucial role in the biological fate of the NPs. While the effects of various physicochemical parameters on the composition of the corona have been explored in depth, the role of temperature upon its formation has received much less attention. In this work, we have probed the effect of temperature on the protein composition on the surface of a set of NPs with various surface chemistries and electric charges. Our results indicate that the degree of protein coverage and the composition of the adsorbed proteins on the NPs' surface depend on the temperature at which the protein corona is formed. Also, the uptake of NPs is affected by the temperature. Temperature is, thus, an important parameter that needs to be carefully controlled in quantitative studies of bionano interactions.
METAL COMPLEXES AS NEW PRO-ECOLOGICAL CROSSLINKING AGENTS FOR CHLOROPRENE RUBBER BASED ON HECK COUPLING REACTION (2019)

ABSTRACT The influence of new pro-ecological curing agents on the crosslinking process of chloroprene rubber (CR) was examined. The proposed curing system used a simpler recipe (no need to apply harmful products such as zinc oxide and ethylene thiourea) and cost less than standard metal oxides. It was expected that the mechanism of crosslinking would be similar to that of Heck-type reactions. Heck-type reactions are powerful tools for the creation of new C=C bonds. They provide the simplest and most efficient way to synthesize a variety of important compounds used in many areas, such as pharmaceuticals, antioxidants, ultraviolet absorbers, and industrial applications. However, despite their wide application, Heck-type reactions have not been used in the rubber industry so far. Rubber blends containing acetylacetonates with different transition metals as new crosslinking agents were filled with fumed silica Aerosil 380 or carbon black Corax N-550. It was found that metal complexes are active crosslinking agents of the CR composites. The obtained vulcanizates were characterized by a high degree of crosslinking and good mechanical properties. Considering the high tensile strength and degree of crosslinking, iron acetylacetonate was the most effective curing agent of the used metal complexes. Compared with the reference sample cured with metal oxides, the CR samples crosslinked using metal acetylacetonates had a higher activity.
A double oracle algorithm for zero-sum security games on graphs (2011)

In response to the Mumbai attacks of 2008, the Mumbai police have started to schedule a limited number of inspection checkpoints on the road network throughout the city. Algorithms for similar security-related scheduling problems have been proposed in recent literature, but security scheduling in networked domains when targets have varying importance remains an open problem at large. In this paper, we cast the network security problem as an attacker-defender zero-sum game. The strategy spaces for both players are exponentially large, so this requires the development of novel, scalable techniques.We first show that existing algorithms for approximate solutions can be arbitrarily bad in general settings. We present Rugged (Randomization in Urban Graphs by Generating strategies for Enemy and Defender), the first scalable optimal solution technique for such network security games. Our technique is based on a double oracle approach and thus does not require the enumeration of the entire strategy space for either of the players. It scales up to realistic problem sizes, as is shown by our evaluation of maps of southern Mumbai obtained from GIS data.
Reliable gender screening for human preimplantation embryos, using multiple DNA target-sequences (1992)

Dependable methods were developed for preimplantation sexing of human IVF embryos, for use in clinical settings where prospective parents are at high risk for transmission of X-linked diseases. Using single cultured cells and blastomeres from human embryos as model systems, a multiplex protocol was developed for rapid analysis via nested polymerase chain reaction (PCR). Reliability was enhanced by co-amplification of conserved amelogenin gene segments from both X and Y chromosomes, as well as Y-linked DYZ1 repetitive elements. Each cell was manually isolated and individually washed to avoid potential contaminants. Multiplex amplification allowed recognition of spurious amplification failures specific to particular amelogenin single-copy targets. The X-linked internal control and multiple Y-linked markers allowed recognition and exclusion of most aberrant samples, thus averting potential misdiagnosis. The optimized single-cell protocol reduced experimental sexing errors to < 2% (1/60), but also revealed potential pitfalls of single-cell analysis. With human triploid embryos, separate sampling of individual blastomeres provided concordant female or male signals. Slight modification adapted the procedure for diagnosis of biopsy material from blastocyst stage embryos, allowing separate analysis of multiple tubes containing multiple cells for improved reliability.
A Piperidine Amide Extracted from <i>Piper longum</i> L. Fruit Shows Activity against <i>Aedes aegypti</i> Mosquito Larvae (2002)

Mosquito larvicidal activity of Piper longum fruit-derived materials against the fourth-instar larvae of Aedes aegypti was examined. A crude methanol extract of P. longum fruits was found to be active against the larvae, and the hexane fraction of the methanol extract showed a strong larvicidal activity of 100% mortality. The biologically active component of P. longum fruits was characterized as pipernonaline by spectroscopic analyses. The LC(50) value of pipernonaline was 0.25 mg/L. The toxicity of pipernonaline is comparable to that of pirimiphos-methyl as a mosquito larvicide. In tests with available components derived from P. longum, no activity was observed with piperettine, piperine, or piperlongumine.
Effects of carrier pulse rate and stimulation site on modulation detection by subjects with cochlear implants (2007)

Most modern cochlear-implant speech processors convey speech-envelope information using amplitude-modulated pulse trains. The use of higher-rate carrier pulse trains allows more envelope detail in the signal. However, neural response properties could limit the efficacy of high-rate carriers. This study examined effects of carrier rate and stimulation site, on psychophysical modulation detection thresholds (MDTs). Both of these variables could affect the neural representation of the carrier and thus affect perception of the modulation. Twelve human subjects with cochlear implants were tested. Phase duration of symmetric biphasic pulses was modulated sinusoidally at 40 Hz. MDTs were determined for monopolar stimulation at two carrier rates [250 and 4000 pulses/s (pps)], three stimulation sites (basal, middle, and apical), and five stimulus levels (10%, 30%, 50%, 70%, and 90% of the dynamic range). MDTs were lower for 250 pps carriers than for 4000 pps carriers in 71% of the 180 cases studied. Effects of carrier rate were greatest at the apical stimulation site and effects of stimulation site on MDTs depended on carrier rate. The data suggest a distinct disadvantage to using carrier pulse rates as high as 4000 pps. Stimulation site should be considered in evaluating modulation detection ability.
Lipase-Catalyzed Oligomerization and Hydrolysis of Alkyl Lactates: Direct Evidence in the Catalysis Mechanism That Enantioselection Is Governed by a Deacylation Step (2010)

Lipase-catalyzed oligomerization of alkyl d- and l-lactate monomers (RDLa and RLLa, respectively) was studied for the first time. It has been found that the oligomerization occurs enantioselectively only for d-lactates to give oligomers up to heptamers of lactic acid (LA) in good to high yields by using primary C1 to C8 alkyl groups and sec-butyl group for d-lactate monomers. No reaction happened for all l-lactates in similar conditions. Lipase-catalyzed hydrolysis of alkyl d- and l-lactates was also examined, revealing that the hydrolysis took place for both d- and l-lactates, although l-lactates proceeded a couple of times slower. The hydrolysis results clearly demonstrate that the lipase catalysis mechanism involves an acyl-enzyme intermediate (EM) formation via the acylation step from both d- and l-lactates as a rate-determining step, and the subsequent deacylation step, a nucleophilic attack of water to the EM, takes place to produce free LA. On the other hand, in the oligomerization of d-lactates, the deacylation step, in which a sec-alcohol group of the monomer or of the propagating chain-end attacks to the EM, is only allowed for the sec-d-alcohol group to give a one-LA-unit-elongated oligomer. l-Lactates form the EM; however, the subsequent deacylation reaction with both the sec-l- and sec-d-alcohol groups does not take place, failing in the oligomerization to occur. These results provide with the first direct evidence in the lipase catalysis that the enantioselection is governed by the deacylation step. In the co-oligomerization between l- and d-lactates, the l-isomer retarded the reaction rate of the d-isomer, which was found due to the function of the former as a competitive inhibitor in the acylation step toward the latter.
Antilipidemic drugs. Part 3: On the synthesis of 14C-radiolabelled isopropyl-[4'-chlorobenzoyl)-2-phenoxy-2-methyl]-propionate (LF-178). (1976)

Isopropyl-[4'-(p-chlorobenzoyl)-2-phenoxy-2 methyl]-propionate (LF 178; procetofene; Lipanthyl¿) was labelled with 14C. The carbon atom of the ketone function was chosen for the study. The obtained product has a total specific radioactivity of 8.79 mCi/mM. Its structure was proved by NMR.
Maintainability: A Key to Effective Serviceability and Maintenance Management (1995)

Planning for Maintainability. Organization for Maintainability. The Measures of Maintainability. Development of the Maintenance Concept. Maintainability Analysis. Maintainability in Design. Maintainability Prediction. Maintenance Task Analysis (MTA). Formal Design Review. Maintainability Test and Demonstration. Maintainability Applcations for Operating Systems. Appendices. Index.
Construction of Single Chain Variable Fragment (ScFv) and BiscFv-Alkaline Phosphatase Fusion Protein for Detection of <i>Bacillus </i><i>A</i><i>nthracis</i> (2006)

This paper describes an attempt for convenient and sensitive detection of Bacillus anthracis with single chain variable fragment (scFv)-based protein chip. Phage display technology was employed to generate scFv by using the protective antigen (PA) of B. anthracis for immunization. V(H) and V(L) genes of the scFv were amplified separately by reverse transcriptase-PCR from mRNA of immunized mice and then assembled into scFv gene with a linker DNA sequence. The scFv gene was inserted into a phagemid vector pCANTAB-5E and then transformed into Escherichia coli TG1 to yield recombinant phages after infection with helper phage M13KO7. After six rounds of panning with PA, the phage clones displaying scFv fragments of the antibody were selected by ELISA. One phage clone scFv-6w10 showing the strongest positive signal in ELISA was selected. To enhance the affinity of the scFv-6w10, a recombinant bivalent single-chain Fv antibody (biscFv-6w10) directed against PA was constructed and tested in functional assays. The affinity of the biscFv-6w10 was much higher than that of scFv-6w10 and reached 6.5 x 10(9) M(-1). An expression system was constructed for the production of E. coli alkaline phosphatase (EAP) labeled biscFv-6w10 (biscFv-6w10-EAP) in E. coli cells. The expressed fusion protein retained both antigen-specific binding and enzymatic activity and thus directly served as an enzyme-labeled antibody. Detections of PA and bacterial cells of B. anthracis using biscFv-6w10-EAP and Cy3-labeled biscFv-6w10 were performed on a protein chip. The fusion protein (biscFv-6w10-EAP) chip could detect 10 pg of PA and 500-1000 bacterial cells in approximately 2 h, while the sensitivity of Cy3-labeled protein chip reached 1 pg of PA and 50-100 cells within 2 h.
Bromelain Inhibits SARS-CoV-2 Infection in VeroE6 Cells (2020)

Bromelain inhibits / cleaves the expression of ACE-2 and TMPRSS2Bromelain cleaves / degrades SARS-CoV-2 spike proteinBromelain inhibits S-Ectodomain binding and SARS-CoV-2 infection.
Thermogravimetric analyzer/atmospheric pressure chemical ionization tandem triple quadrupole mass spectrometer system for evolved gas analysis (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermogravimetric analyzer/atmospheric pressure chemical ionization tandem triple quadrupole mass spectrometer system for evolved gas analysisR. Bruce. Prime and Bori. ShushanCite this: Anal. Chem. 1989, 61, 11, 1195–1201Publication Date (Print):June 1, 1989Publication History Published online1 May 2002Published inissue 1 June 1989https://pubs.acs.org/doi/10.1021/ac00186a004https://doi.org/10.1021/ac00186a004research-articleACS PublicationsRequest reuse permissionsArticle Views133Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts