gebhart/patrepeval huggingface dataset:
Steroids and terpenoid from Mimosa pudica roots (2006)

Department of Chemistry, Tripura University, Suryamaninagar, Agartala-799 130, Tripura. India <em>E-mail :</em> dindabtu@rediffmail.com Fax : 91-0381-2374801 School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo-108 8641, Japan <em>Manuscript received 23 February 2006, revised 4 May 2006, accepted 3 July 2006</em> One new sterolglucoside 1 along with stigmasterol, β-sitosterol and betulinic acid isolated from the roots of Mimosa pudica has been characterized as 4-α,24-dimethylcholest-7-en-3β-ol-3β-D-glucoside.This report of isolation of stigmasterol and betulinic acid is for the first time from this plant and β-sitosterol was reported earlier from its aerial parts.
Identification of Genes Controlling Growth Polarity in the Budding Yeast <i>Saccharomyces cerevisiae</i>: A Possible Role of <i>N</i>-Glycosylation and Involvement of the Exocyst Complex (1997)

The regulation of secretion polarity and cell surface growth during the cell cycle is critical for proper morphogenesis and viability of Saccharomyces cerevisiae. A shift from isotropic cell surface growth to polarized growth is necessary for bud emergence and a repolarization of secretion to the bud neck is necessary for cell separation. Although alterations in the actin cytoskeleton have been implicated in these changes in secretion polarity, clearly other cellular systems involved in secretion are likely to be targets of cell cycle regulation. To investigate mechanisms coupling cell cycle progression to changes in secretion polarity in parallel with and downstream of regulation of actin polarization, we implemented a screen for mutants defective specifically in polarized growth but with normal actin cytoskeleton structure. These mutants fell into three classes: those partially defective in N-glycosylation, those linked to specific defects in the exocyst, and a third class neither defective in glycosylation nor linked to the exocyst. These results raise the possibility that changes in N-linked glycosylation may be involved in a signal linking cell cycle progression and secretion polarity and that the exocyst may have regulatory functions in coupling the secretory machinery to the polarized actin cytoskeleton.
Crosslinking chemistry and network structure in high solids acrylic-melamine coatings (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrosslinking chemistry and network structure in high solids acrylic-melamine coatingsDavid R. Bauer and Gregory F. BuddeCite this: Ind. Eng. Chem. Prod. Res. Dev. 1981, 20, 4, 674–679Publication Date (Print):December 1, 1981Publication History Published online1 May 2002Published inissue 1 December 1981https://pubs.acs.org/doi/10.1021/i300004a016https://doi.org/10.1021/i300004a016research-articleACS PublicationsRequest reuse permissionsArticle Views359Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Variable-gap structures in electron-beam-pumped semiconductor lasers (1978)

A theoretical analysis is made of the active carrier distribution and carrier collection efficiency in threelayer and variable-gap structures in electron-beam-pumped semiconductors. It is shown that these structures make it possible to lower the laser stimulated emission threshold by more than an order of magnitude with a carrier collection efficiency of up to 100%.
Overview of phase I/II pemetrexed studies. (2004)

Pemetrexed (Alimta) is an antifolate that is effective in the inhibition of multiple enzyme targets including thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyl transferase. The compound has been evaluated in several phase I trials, both as single agent and in combination with other cytotoxic agents. The initial schedule selected for further investigation in phase II trials was pemetrexed 600 mg/m2 as a 10-minute infusion on day 1 every 21 days. During the subsequent phase II development the dose of pemetrexed was adjusted to 500 mg/m2 due to bone marrow and gastrointestinal toxicities. The adjusted dose of pemetrexed was well tolerated throughout the late-phase drug development program. Preclinical evidence suggests that pemetrexed has additive or synergistic activity when combined with many other clinically important anticancer agents, including gemcitabine (Gemzar), fluorouracil, carboplatin (Paraplatin), oxaliplatin (Eloxatin), paclitaxel, and vinorelbine (Navelbine). Dose-limiting toxicities in these studies were primarily hematologic, and there was no evidence of cumulative hematologic toxicity. During the drug development program it was discovered that supplementation with folic acid and vitamin B12 profoundly increased the tolerability of pemetrexed. The studies discussed in this review demonstrate that pemetrexed is well tolerated as a single agent and will be an important contribution to combination chemotherapy regimens.
TC-CSBP: Compressive sensing for time-correlated data based on belief propagation (2011)

Existing compressive sensing techniques mostly consider the sparsity of signals in one dimension. However, a very important case that has rarely been studied is when the signal of interest is time varying and signal coefficients have correlation in time. Our proposed algorithm in this paper is a structure-aware version of the compressive sensing reconstruction via belief propagation proposed by Baron et al. that exploits the time correlation between the signal components and provides the belief propagation algorithm with more accurate initial priors. Numerical simulations show that the belief propagation-based compressive sensing algorithm is able to utilize the side information about signals time correlation and results in enhanced reconstruction performances.
HTLV-II Seroprevalence in Pygmies Across Africa Since 1970 (1993)

HTLV-II-specific antibodies, with patterns similar to those in the Americas, were present in sera collected about 1970 from Bambuti pygmies in Zaire (14/102; 14%) and from pygmies in Cameroon (5/214; 2.3%), and were more prevalent than HTLV-I. In the Central African Republic, 504 pygmies were HTLV negative. After finding of 4 HTLV-II seropositives among 12 Bambuti pygmies sampled in 1991, this established that HTLV-II or a related retrovirus is present as an ancient endemic in some, but not all, insulated groups of African pygmies, similar to the HTLV-II distribution in Amerindian populations. The endemic among the oldest inhabitants of central Africa, and the occasional and scattered occurrence of apparent HTLV-II among predominant HTLV-I in other Africans, fit well with an ancient African virus and not with importation from the New World. Theories on the origin and evolution of the primate T-lymphotropic viruses (PTLVs) should take into account the longstanding presence of HTLV-II-type viruses in both the Old and New World. Present serology suggests identity of the African viruses with HTLV-II, but their assignment to a new HTLV type is open should genetic analysis show strong divergence from American HTLV-II. Clinical expression, if any, remains to be studied.
Optimized speech balloon placement for automatic comics generation (2013)

Comic presentation for videos has attracted more and more attention in recent years. This work deeply discusses one important component, i.e., speech balloon placement, that was depreciated and was done by heuristic approaches before. According to number of words and emotion embedded in subtitles, and audio energy corresponding to the targeted frame, speech balloons of various sizes and appropriate shapes are generated. How to locate speech balloons in panels at the same comic page is then formulated as an optimization problem. The objective function integrates an intra-panel cost with an inter-panel cost, where the former is designed to avoid occluding important regions of frames and to direct viewer's gaze, and the latter is designed to build the reading tempo. The experimental results show that the proposed method facilitates higher readability, higher content coverage, and better speech balloon placement.
A built-in performance-monitoring/fault isolation and correction (PM/FIC) system for active phased-array antennas (1993)

A built-in performance-monitoring/fault isolation and correction (PM/FIC) system for an active phased-array antenna has been developed and tested. This PM/FIC system employs a transmission line signal injector embedded at the radiating aperture together with a phase-toggling technique for signal detection. Hardware components for a demonstration test-array have been developed, fabricated, and assembled. Eight active elements are fed by four dual-channel transmit/receive (T/R) modules in a column array. Far-field range tests and fault correction tests have also been performed to demonstrate the PM/FIC functions on this test array. Good results have been obtained from these tests. The measurement accuracy of the phase-toggling method is compared with an HP8510 measurement system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Section B. Bacteriology: The flavour of Cheddar cheese (1961)

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Efficient realization of a cal video decoder on a mobile terminal (position paper) (2008)

Resource utilization is a very central issue in the development of large-volume embedded systems. Increasingly complex execution platforms for embedded multimedia systems challenge the prevailing approach of achieving high utilization by carefully tuned implementations in C and assembly language. The recently started ACTORS project addresses resource utilization by providing appropriate high-level abstractions. Algorithms will be specified in a dataflow programming model. This position paper describes the dataflow compilation subproject within ACTORS, and the plans for a demonstrator in the form of a wireless video player, which will be compiled from a library of dataflow components. We give an account for existing software synthesis techniques and the challenges that anticipate in applying them to complex dataflow models.
Hunger and Satiety in Humans During Parenteral Hyperalimentation (1974)

Fifty patients treated with intravenous hyperalimentation were observed while receiving from 1200-4800 kcal per day via a central venous catheter. They were observed while receiving only intravenous nutrition and also while receiving nutrition by mouth as well as by vein. Assessment of degree of hunger and satiety were made and compared with records of body weight, temperature, blood sugar level, and amount and duration of intravenous nutrients. Most patients reported hunger during therapy in spite of the intravenous calories. The onset of satiety was hastened by the intravenous nutrients and although patients would report mild to ravenous hunger while on intravenous nutrients alone, they were able to eat only small amounts of food when oral feeding was initiated. Four patients received intravenous fat emulsions in addition to the carbohydrate-amino acid solution. These patients did not experience hunger during the 24-hr period after fat administration.
Synthesis of 1, 5-Benzothiazepine Derivatives. III (1971)

Various derivatives of 2-aryl-3-hydroxy-2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-one (I) were synthesized. Alternative routes to 2-aryl-3-hydroxy-5-alkyl-trans-2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-one (II-β) and 2-aryl-3-acetoxy-5-dimethylaminoethyl-cis-2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-one (VI-α) were also investigated respectively.
Effect of ganglioside GT1b on the <i>in vitro</i> maturation of porcine oocytes and embryonic development (2015)

Ganglioside is an acidic glycosphingolipid with sialic acids residues. This study was performed to investigate the effect and mechanism of ganglioside GT1b in porcine oocytes in the process of in vitro maturation (IVM) and preimplantation development. Metaphase II (MII) rates were significantly (P < 0.05) different between the control group and the 5 nM GT1b treatment group. Intracellular glutathione (GSH) levels in oocytes matured with 5 nM and 20 nM and GT1b decreased significantly (P < 0.05). The 10 nM group showed a significant (P < 0.05) decrease in intracellular reactive oxygen species (ROS) levels compared with the control group. Subsequently, the level of intracellular Ca(2+) in oocytes treated with different concentrations of GT1b was measured. Intracellular Ca(2+) was significantly (P < 0.05) increased with a higher concentration of GT1b in a dose-dependent manner. Real-time PCR was performed and showed that the expression of bradykinin 2 receptor (B2R) and calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ) in cumulus cells was significantly (P < 0.05) decreased in the 20 nM GT1b treatment group. Treatment with 5 nM GT1b significantly (P < 0.05) decreased the expression of CaMKIIδ. In oocytes, treatment with 5 nM GT1b significantly (P < 0.05) decreased CaMKIIγ and POU5F1 (POU domain, class 5, transcription factor 1). However, treatment with 20 nM GT1b significantly (P < 0.05) increased the expression of POU5F1. Finally, embryonic developmental data showed no significant differences in the two experiments (parthenogenesis and in vitro fertilization). In conclusion, the results of the present study indicated that GT1b plays an important role in increasing the nuclear maturation rate and decreasing the intracellular ROS levels during IVM. However, GT1b inhibited maturation of the cytoplasm by maintaining intracellular Ca(2+) in the process of oocyte maturation regardless of the cell cycle stage. Therefore, GT1b is thought to act on another mechanism that controls intracellular Ca(2+).
Edge Data Processing (2016)

A MapReduce-based framework for processing data at edges, including nodes on the Internet of Things (IoT), is presented in this paper. Although MapReduce processing and its clones have been designed for high-performance server clusters, the processing itself is simple and generalized, so it should be used in non-high-performance computing environments, e.g., IoT and sensor networks. The proposed framework deploys programs for data processing at the nodes that contain the target data as a map step and executes the programs with the local data. Finally, it aggregates the results of the programs to certain nodes as a reduce step. The architecture of the framework, its basic performance, and its application are also described here.
CooVar: Co-occurring variant analyzer (2012)

CooVar is an easy-to-use and lightweight variant annotation tool that considers the combined impact of GVs on protein-coding transcripts. CooVar is freely available at http://genome.sfu.ca/projects/coovar/.
New Criterion for Evaluation of Honey: Quantification of Royal Jelly Protein Apalbumin 1 in Honey by ELISA (2010)

The 55 kDa major protein of royal jelly, named apalbumin 1, is an authentic protein of honey and pollen pellet, and for its quantification an enzyme-linked immunosorbent assay (ELISA) was developed using specific polyclonal anti-apalbumin 1 antibody. The limit of detection for apalbumin 1 was 2 ng mL(-1). The floral honeys contained apalbumin 1 as follows: acacia, 0.011%; linden, 0.010%; chestnut, 0.029%; rape, 0.010%; and dandelion, 0.014%. The saccharose syrup honey contained only 0.001% of apalbumin 1. The average amount of apalbumin 1 relating to the total protein content of analyzed honey samples was 23.39%, whereas in SCCH apalbumin 1 presented only 4.81% of total proteins of honey. Apalbumin 1 is thermostabile in honey at 80 degrees C incubated for 40 min. ELISA results show good precision in the evaluation of apalbumin 1 quantity in honey (CV ranged from 0.69 to 4.25%).
A Novel Three-Phase High-Power Soft-Switched DC/DC Converter for Low-Voltage Fuel Cell Applications (2005)

An efficient dc/dc converter is needed as the interface between a low-voltage fuel cell source and a high-voltage bus for inverter operation. In this paper, a three-phase transformer-isolated dc/dc converter utilizing phase-shift (PS) modulation is proposed. The converter must be able to boost the voltage significantly and operate at current levels above 240 A on the source side. Key features of the proposed converter include reduced transformer turns ratio by a factor of two while maintaining the same output voltage, reduced size of passive components including output filter and input dc bus capacitor using three-phase interleaving, eliminated inductor current ripple at PS angles above 120/spl deg/, and achieved soft switching over a wide load range without auxiliary circuitry. The proposed converter has been analyzed, simulated, and implemented in hardware. An efficiency of above 96% was achieved using the prototype unit. Experimental results were used to verify all designs and analyses.
The Production of Glucooligosaccharides by Leuconostoc Mesenteroides ATCC 13146 and Lipomyces Starkeyi ATCC 74054. (1997)

Glucooligosaccharides of less than DP 10 were produced either by mixed cultures of Leuconostoc mesenteroides ATCC 13146 and L. starkeyi ATCC 74054, or by an acceptor reaction produced by Leuconostoc mesenteroides ATCC 13146. The yields of glucooligosaccharides produced by mixed culture and acceptor reaction reached up to 49 and 90% of theoretical yield. The composition of carbohydrates at the end of fermentation by mixed culture was 31.4% oligosaccharides, 17.6% dextran, 31.4% mannitol, 2.1% fructose, and 2.4% of sucrose. The composition of carbohydrates at the end of fermentation by acceptor reaction was 32.7% pannose, 30.4% branched isomaltotetraose (DP 4), 21.7% branched DP 5, 5.2% branched DP 6, and 3.6% branched DP 7, and 6.5% maltose. The oligosaccharides produced suppressed growth of Salmonella enteritidis, Salmonella typhimurium, Staphylococcus aureus, Staphylococcus epidermidis, and Clostridium perfringenes. Bifidobacterium bifidum and Bifidobacterium fullorum completely utilized the oligosaccharides as carbon sources in 48 hr.
Apoptosis-Linked Gene 2-Deficient Mice Exhibit Normal T-Cell Development and Function (2002)

The apoptosis-linked gene product, ALG-2, is a member of the family of intracellular Ca(2+)-binding proteins and a part of the apoptotic machinery controlled by T-cell receptor (TCR), Fas, and glucocorticoid signals. To explore the physiologic function of ALG-2 in T-cell development and function, we generated mice harboring a null mutation in the alg-2 gene. The alg-2 null mutant mice were viable and fertile and showed neither gross developmental abnormality nor immune dysfunction. Analyses of apoptotic responses of ALG-2-deficient T cells demonstrated that ALG-2 deficiency failed to block apoptosis induced by TCR, Fas, or dexamethasone signals. These findings indicate that ALG-2 is physiologically dispensable for apoptotic responses induced by the above signaling pathways and suggest that other functionally redundant proteins might exist in mammalian cells.
Simulation of nitrogen uptake, fixation and leaching in a grass/white clover mixture (1999)

To represent nitrogen cycling in a low input grass/legume pasture system, a previously developed, weather‐driven grass/white clover growth model has been adapted to become the crop growth component of the soil nitrogen dynamics model SOILN. This provides a means of simulating nitrogen uptake by a grass/white clover crop, an important component of the overall nitrogen balance in low‐input grassland systems. Crop growth is represented by a photosynthesis equation adapted to take account of competition between the two crops for resources of light, water and nitrogen in the soil. Water shortage is represented by linked simulations with the soil water and heat model SOIL, and nitrogen shortage by links with the SOILN model. Nitrogen fixation has been introduced according to an equation for potential fixation reduced by environmental factors, particularly temperature. Transfer of nitrogen‐rich clover plant material to the soil nitrogen pools of SOILN (from where it becomes available as a nutrient for grass) is also represented. The model is tested by comparing simulated cut crop yields and nitrogen content of cut material with measured data from perennial ryegrass/white clover at a test site. Soil nitrogen processes in the model are tested by comparing simulated and measured nitrate in drainflows. Apart from some discrepancies between simulated and measured results attributable to the inherent instability of a mixed crop system, agreement is reasonable by the standards of biological system models, indicating that the combined model gives a realistic representation of carbon and nitrogen processes in grassland with a grass, legume mixed crop.
A near perfect stable random access protocol for a broadcast channel (2003)

A near perfect stable random access protocol for a broadcast channel, the distributed queuing random access protocol (DQRAP), is presented and evaluated. The DQRAP protocol utilizes minislots to provide ternary channel feedback and two distributed queues to resolve contention and to schedule the transmission of messages. Modeling and simulation indicate that the DQRAP protocol, using as few as three minislots, achieves a performance level which approaches that of a hypothetical perfect scheduling protocol, i.e., the M/D/1 system, with respect to throughput and delay. The DQRAP protocol is stable and not sensitive to propagation delay and thus offers the potential of improved performance over current protocols in satellite, metropolitan and packet radio networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Oxime Amides as a Novel Zinc Binding Group in Histone Deacetylase Inhibitors: Synthesis, Biological Activity, and Computational Evaluation (2011)

Several oxime containing molecules, characterized by a SAHA-like structure, were explored to select a potentially new biasing binding element for the zinc in HDAC catalytic site. All compounds were evaluated for their in vitro inhibitory activity against the 11 human HDACs isoforms. After identification of a “hit” molecule, a programmed variation at the cap group and at the linker was carried out in order to increase HDAC inhibition and/or paralogue selectivity. Some of the new derivatives showed increased activity against a number of HDAC isoforms, even if their overall activity range is still far from the inhibition values reported for SAHA. Moreover, different from what was reported for their hydroxamic acid analogues the new α-oxime amide derivatives do not select between class I and class II HDACs; rather they target specific isoforms in each class. These somehow contradictory results were finally rationalized by a computational assisted SAR, which gave us the chance to understand how the oxime derivatives interact with the catalytic site and justify the observed activity profile.