gebhart/patrepeval huggingface dataset:
Human Immunodeficiency Virus Infection, the Acquired Immunodeficiency Syndrome, and Inflammatory Bowel Disease (1996)

The objective of this study was to determine the effect of human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) on inflammatory bowel disease (IBD). A retrospective survey of the medical records of St. Paul's Hospital and its AIDS-care physicians/gastroenterologists searching for patients with both HIV/AIDS and IBD was conducted. Of 1,839 hospitalized patients (4,459 hospital admissions) from 1989 to 1993, two patients with AIDS/HIV and IBD were found. The physician survey revealed four patients for a total of six patients. Four patients developed de novo IBD--two ulcerative colitis (UC), one Crohn's disease (CrD), and one indeterminate colitis (IC)--after HIV infection. Two patients had UC predating HIV seroconversion. The absolute CD4 count of patients with de novo IBD was 210-700 cells/ml at the time of IBD. The patient with IC maintained quiescent IBD from a CD4 count of 190-30 cells/ml. The other had many relapses before HIV seropositivity. With CD4 count depletion, disease activity improved. IBD medications were discontinued at a CD4 count of 130 cells/ml. Diarrhea returned at a CD4 count of 20 cells/ml; however, sigmoidoscopy was unremarkable, and mucosal biopsy revealed cryptosporidiosis without active UC. No patient had an AIDS-related illness during active IBD. Two patients followed to CD4 counts of < 30 cells/ml suffered AIDS-related infections with quiescent IBD. With a progressive decline in CD4 count, IBD disease activity may improve and remit. The CD4 count at which remission occurs may reflect severe immunodeficiency such that risk for AIDS-related infection is high. Active IBD may occur with lesser degrees of immunodeficiency.
Exposing Fine-Grained Parallelism in Algebraic Multigrid Methods (2012)

Algebraic multigrid methods for large, sparse linear systems are a necessity in many computational simulations, yet parallel algorithms for such solvers are generally decomposed into coarse-grained tasks suitable for distributed computers with traditional processing cores. However, accelerating multigrid methods on massively parallel throughput-oriented processors, such as graphics processing units, demands algorithms with abundant fine-grained parallelism. In this paper, we develop a parallel algebraic multigrid method which exposes substantial fine-grained parallelism in both the construction of the multigrid hierarchy as well as the cycling or solve stage. Our algorithms are expressed in terms of scalable parallel primitives that are efficiently implemented on the GPU. The resulting solver achieves an average speedup of $1.8\times$ in the setup phase and $5.7\times$ in the cycling phase when compared to a representative CPU implementation.
Relative Importance of Heat-Labile Enterotoxin in the Causation of Severe Diarrheal Disease in the Gnotobiotic Piglet Model by a Strain of Enterotoxigenic <i>Escherichia coli</i> That Produces Multiple Enterotoxins (2004)

Enterotoxigenic Escherichia coli (ETEC) strains that produce multiple enterotoxins are important causes of severe dehydrating diarrhea in human beings and animals, but the relative importance of these enterotoxins in the pathogenesis is poorly understood. Gnotobiotic piglets were used to study the importance of heat-labile enterotoxin (LT) in infection with an ETEC strain that produces multiple enterotoxins. LT(-) (DeltaeltAB) and complemented mutants of an F4(+) LT(+) STb(+) EAST1(+) ETEC strain were constructed, and the virulence of these strains was compared in gnotobiotic piglets expressing receptors for F4(+) fimbria. Sixty percent of the piglets inoculated with the LT(-) mutant developed severe dehydrating diarrhea and septicemia compared to 100% of those inoculated with the nalidixic acid-resistant (Nal(r)) parent and 100% of those inoculated with the complemented mutant strain. Compared to piglets inoculated with the Nal(r) parent, the mean rate of weight loss (percent per hour) of those inoculated with the LT(-) mutant was 67% lower (P < 0.05) and that of those inoculated with the complemented strain was 36% higher (P < 0.001). Similarly, piglets inoculated with the LT(-) mutant had significant reductions in the mean bacterial colony count (CFU per gram) in the ileum; bacterial colonization scores (square millimeters) in the jejunum and ileum; and clinical pathology parameters of dehydration, electrolyte imbalance, and metabolic acidosis (P < 0.05). These results indicate the significance of LT to the development of severe dehydrating diarrhea and postdiarrheal septicemia in ETEC infections of swine and demonstrate that EAST1, LT, and STb may be concurrently expressed by porcine ETEC strains.
Monoclonal antibody-purified antigen for the immunodiagnosis of trichinosis (1984)

Monoclonal antibodies generated from spleen cells of Balb/cJ mice infected with Trichinella spiralis reacted with antigenic determinants present in some other common swine parasites, especially Trichuris suis. An antigenic determinant unique to T spiralis was recognized by one immunoglobulin M monoclonal antibody (7C2C5); this determinant was found on larval T spiralis proteins with molecular weights of 53,000, 49,000, and 45,000. These proteins were components of in vitro-derived worm excretory-secretory products. Immunoperoxidase staining techniques and reactions of the monoclonal antibody with living parasites indicated that the source of the antigen was the stichocyte. Two of the proteins (53,000 and 49,000 molecular weight) possessing this determinant were isolated by monoclonal antibody-affinity chromatography, using hybridoma 7C2C5. When used in a serologic enzyme-linked immunosorbent assay, the affinity-isolated antigen was able to completely eliminate false-positive reactions with serum from healthy swine and to detect all pigs infected with T spiralis.
Ependymin as a substrate for outgrowth of axons from cultured explants of goldfish retina (1991)

Ependymin, a prominent protein of the brain's extracellular fluid (ECF) was previously implicated in the consolidation of memory and in the activity-driven sharpening of the retinotectal projection. Because both these phenomena probably involve the growth and elaboration of appropriate synapses, we have tested whether ependymin can serve as a substrate for the growth of axons from goldfish retinal ganglion cells in a culture assay. Ependymin (Ep), laminin (LAM), polylysine (PL), and Concanavalin A (Con A) were plated on glass coverslips either uniformly or in striped patterns. Ep alone, either soluble or partly polymerized (by dropping calcium concentration and pH), was a good substrate for axonal outgrowth, as good or better than PL and Con A, but not as good as LAM. Neurites grew faster on LAM (71 microns/h) than on Ep (32 microns/h) or on PL (22 microns/h). Fasciculation was low on LAM, intermediate on Ep, and highest on PL. In exclusive side-by-side stripe assays, axons preferred LAM over Ep, but gave weak or no preference for Ep over Con A or PL. With stripes of LAM + Ep alongside pure LAM, the axons preferred the mixture of LAM + Ep. When antibodies to Ep were plated in stripes over continuous Ep substrate, the axons avoided the antibody-blocked stripes and grew on the Ep stripes. Antibodies to Ep did not, however, block growth on laminin substrates, nor did antibodies to LAM block growth on Ep. Dot blots and western blots showed very little cross recognition between the antibodies. Ependymin is a good substrate for neurite outgrowth, which is normally present in ECF, and adhesion to Ep is independent of LAM and possibly additive to it.
Swelling of Filler-Reinforced Vulcanizates (1964)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Gerard Kraus; Swelling of Filler-Reinforced Vulcanizates. Rubber Chemistry and Technology 1 March 1964; 37 (1): 6–13. doi: https://doi.org/10.5254/1.3540317 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search
Pixel Offset Regression (POR) for Single-shot Instance Segmentation (2018)

State-of-the-art instance segmentation methods including Mask-RCNN and MNC are multi-shot, as multiple region of interest (ROI) forward passes are required to distinguish candidate regions. Multi-shot architectures usually achieve good performance on public benchmarks. However, hundreds of ROI forward passes in sequel limits their running efficiency, which is a critical point in several utilities such as vehicle surveillance. As such, we arrange our focus on seeking a well trade-off between performance and efficiency. In this paper, we introduce a novel Pixel Offset Regression (POR) scheme which can simply extend single-shot object detector to single-shot instance segmentation system, i.e., segmenting all instances in a single pass. Our framework is based on VGG16 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> with following four parts: (1) a single-shot detection branch to generate object detections, (2) a segmentation branch to estimate foreground masks, (3) a pixel offset regression branch to effectively estimate the distance and orientation from each pixel to the respective object center and (4) a merging process combining output of each branch to obtain instances. Our framework is evaluated on Berkeley-BDD, KITTI and PASCAL VOC2012 validation set, with comparison against several VGG16 based multi-shot methods. Without whistles and bells, our framework exhibits decent performance, which shows good potential for fast speed required applications.
Layer-by-Layer Assembly of Colloidal CdS and ZnS−CdS Quantum Dots and Improvement of Their Photoluminescence Properties (2009)

Thin films of colloidal CdS and ZnS−CdS alloy quantum dots (QDs) were fabricated by layer-by-layer (LBL) self-assembly to synthesize blue luminescent QD thin films. The assembly of negatively charged colloidal QDs and positively charged poly(diallyldimethylammonium chloride) results in QD/polymer multilayers. The relative intensity of the band-edge photoluminescence (PL) to that of the defect-related PL was decreased during the LBL assembly process. With an additional dipping treatment in a Cd(ClO4)2 aqueous solution with pH 10, the band-edge PL intensity was recovered. The PL decay profiles before and after the dipping treatment were considerably different. From this fact, we conclude that the enhancement of the band-edge PL intensity originates from the reduction of nonradiative recombination processes at the QD surface.
Tea catechin ingestion combined with habitual exercise suppresses the aging-associated decline in physical performance in senescence-accelerated mice (2008)

Catechins, which are abundant in green tea, possess a variety of biologic actions, and their clinical application has been extensively investigated. In this study, we examined the effects of tea catechins and regular exercise on the aging-associated decline in physical performance in senescence-accelerated prone mice (SAMP1) and age-matched senescence-accelerated resistant mice (SAMR1). The endurance capacity of SAMR1 mice, measured as the running time to exhaustion, tended to increase over the 8-wk experimental period, whereas that of SAMP1 mice decreased by 17%. On the other hand, the endurance capacity of SAMP1 mice fed 0.35% (wt/wt) catechins remained at the initial level and was significantly higher than that of SAMP1 mice not fed catechins. In SAMP1 mice fed catechins and given exercise, oxygen consumption was significantly increased, and there was an increase in skeletal muscle fatty acid β-oxidation. The mRNA levels of mitochondria-related molecules, such as peroxisome proliferator-activated receptor-γ coactivator-1, cytochrome c oxidase-II, III, and IV in skeletal muscle were also higher in SAMP1 mice given both catechins and exercise. Moreover, oxidative stress measured as thiobarbituric reactive substances was lower in SAMP1 groups fed catechins than in the SAMP1 control group. These results suggest that long-term intake of catechins, together with habitual exercise, is beneficial for suppressing the aging-related decline in physical performance and energy metabolism and that these effects are due, at least in part, to improved mitochondrial function in skeletal muscle.
Insulin and Insulin-Like Growth Factors (2001)

Insulin and insulin-like growth factors 1 and 2 (Igf1 and Igf2, respectively) are genetically and functionally related peptides with overlapping anabolic and growth-promoting effects (1,2). The actions of insulin are mediated by the insulin receptor, a membrane-bound tyrosine kinase which is activated by ligand binding (3). The actions of both Igfl and 2 are mediated for the most part by the homologous Igf 1 receptor, which engages many of the same intracellular signaling pathways as the insulin receptor (4,5). An Igf2/ mannose-6-phosphate receptor, binds Igf2 and promotes its degradation in the lyzosomal pathway (6). During the past decade, each of these ligands and receptors have been subjected to targeted gene deletions, providing novel insights into growth regulation and ligand-receptor interactions in murine embryonic and postnatal development. This chapter focuses on the developmental and physiological consequences of deletions of Igf1, Igf2, insulin, and the Igf1 and insulin receptors, alone and in combination.
Osmiophilic Reagents: New Cytochemical Principle for Light and Electron Microscopy (1964)

Established histochemical procedures have been altered by utilizing reagents which contain a group capable of reacting selectively with OsO(4). This permits the cytochemical demonstration of a particular enzyme or functional group of a macromolecule with the light and electron microscope. The osmiophilic groups used thus far are mercapto, thiocarbamyl, and diazothioether. The "osmium black" produced at the site of reaction is electron opaque, is insoluble in lipids, and is not altered when the issue is embedded in acrylic and epoxy resins. Its fine amorphous character enables it to be maintained precisely in the electron beam.
A formal approach for network security management based on qualitative risk analysis (2013)

The risk analysis is an important process for enforcing and strengthening efficient and effective security. Due to the significant growth of the Internet, application services, and associated security attacks, information professionals face challenges in assessing risk of their networks. The assessment of risk may vary with the enterprise's requirements. Hence, a generic risk analysis technique is suitable. Moreover, configuring a network with correct security policy is a difficult problem. The assessment of risk aids in realizing necessary security policy. Risk is a function of security threat and impact. Security threats depend on the traffic reachability. Security devices like firewalls are used to selectively allow or deny traffic. However, the connection between the network risk and the security policy is not easy to establish. A small modification in the network topology or in the security policy, can change the risk significantly. It is hard to manually follow a systematic process for configuring the network towards security hardening. Hence, an automatic generation of proper security controls, e.g., firewall rules and host placements in the network topology, is crucial to keep the overall security risk low. In this paper, we first present a declarative model for the qualitative risk analysis. We consider transitive reachability, i.e., reachability considering one or more intermediate hosts, in order to compute exposure of vulnerabilities. Next, we formalize our risk analysis model and the security requirements as a constraint satisfaction problem using the satisfiability modulo theories (SMT). A solution to the problem synthesizes necessary firewall policies and host placements. We also evaluate the scalability of the proposed risk analysis technique as well as the synthesis model.
Buried source-side injection (BSSI) for flash EPROM programming (1992)

A flash-EPROM cell structure that can be programmed at low drain voltages and low power is disclosed. The new element in the device structure is the incorporation of buried junction at the source side where the high electric field region is established during programming. The cell is programmed by hot-electron injection at the source side and erased by Fowler-Nordheim tunneling at the drain side. Typical programming time of 10 mu s/byte can be accomplished with 3.5 V on the drain junction. The structure can be built with the standard EPROM technology and can offer advantages in low-voltage power supply systems such as portable and notebook computers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Phase I Testing of a Malaria Vaccine Composed of Hepatitis B Virus Core Particles Expressing<i>Plasmodium falciparum</i>Circumsporozoite Epitopes (2004)

We report the first phase I trial to assess the safety and immunogenicity of a malaria vaccine candidate, ICC-1132 (Malarivax), composed of a modified hepatitis B virus core protein (HBc) containing minimal epitopes of the Plasmodium falciparum circumsporozoite (CS) protein. When expressed in Escherichia coli, the recombinant ICC-1132 protein forms virus-like particles that were found to be highly immunogenic in preclinical studies of mice and monkeys. Twenty healthy adult volunteers received a 20- or a 50-microg dose of alum-adsorbed ICC-1132 administered intramuscularly at 0, 2, and 6 months. The majority of volunteers in the group receiving the 50-microg dose developed antibodies to CS repeats as well as to HBc. Malaria-specific T cells that secreted gamma interferon were also detected after a single immunization with ICC-1132-alum. These studies support ICC-1132 as a promising malaria vaccine candidate for further clinical testing using more-potent adjuvant formulations and confirm the potential of modified HBc virus-like particles as a delivery platform for vaccines against other human pathogens.
Panhandle Polymerase Chain Reaction Amplifies MLL Genomic Translocation Breakpoint Involving Unknown Partner Gene (1997)

We used a new approach called panhandle polymerase chain reaction (PCR) to clone an MLL genomic translocation breakpoint in a case of acute lymphoblastic leukemia of infancy in which karyotype analysis was technically unsuccessful and did not show the translocation partner. Panhandle PCR amplified known MLL sequence 5′ of the breakpoint and 3′ sequence from the unknown partner gene from a DNA template with an intrastrand loop schematically shaped like a pan with a handle. The 7-kb panhandle PCR product contained the translocation breakpoint in MLL intron 8. The partner DNA included unique nonrepetitive sequences, Alu and mammalian apparent LTR-retrotransposon (MaLR) repetitive sequences, and a region of homology to expressed sequence tags. MaLR sequences have not been found before near leukemia-associated translocation breakpoints. The nonrepetitive sequences were not homologous to known partner genes of MLL. Screening of somatic cell hybrid and radiation hybrid lines by PCR and fluorescence in situ hybridization analysis of normal metaphase chromosomes mapped the partner DNA to chromosome band 4q21. Reverse transcriptase-PCR identified an MLL-AF-4 chimeric mRNA, indicating that panhandle PCR identified a fusion of MLL with a previously uncharacterized AF-4 intronic sequence. Panhandle PCR facilitates cloning translocation breakpoints and identifying unknown partner genes.
High-rate evaporation/deposition processes of metals, alloys, and ceramics for vacuum metallurgical applications (1974)

This is a review on high-rate evaporation/deposition processes for metals, alloys, and ceramics. These processes are described. The influence of process variables on the microstructure and mechanical properties of the deposits is discussed. Present and potential applications are presented.
High Precision Superconducting Magnets (1977)

Window-frame type superconducting dipole magnets have demonstrated accuracy and predictability of fields which compare well with the best conventional accelerator-type magnets. Precision measurements were made on the two series powered 2 m long 4 T modules comprising the 80 bending magnet at BNL after two years of beam operation including several dozen beam induced quenches. The integral field of the two units is identical to measurement accuracy, ≤ 1 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> parts at ~ full aperture, for all multipoles except quadrupole. Random quadrupole terms of G/B = 6 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> or 2 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> parts are present. A 1 m long 6 T model of more advanced design shows pure dipole field, at all field levels, to 1 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> parts, using a single correction coil with predetermined excitation. The field shape at ~ 0.5 T/sec rise rate is identical to dc. The advantages of the extended current sheet coil construction are discussed. Results will be compared with computer simulations of construction errors. Suitable conceptual designs of compact 6 T dipoles and of quadrupoles applied to a 1 km accelerator lattice will be presented.
Human Studies in the Development of Human Immunodeficiency Virus Vaccines (1995)

The safety and immunogenicity of candidate human immunodeficiency virus type 1 (HIV-1) vaccines have been studied in > 1500 healthy, seronegative (HIV-1-uninfected) subjects. HIV-1 envelope proteins, gp160 and gp120, have been the most extensively investigated. A live virus vector construct, vaccinia with insertion of the HIV-1 env gene, has also been studied. HIV-1 candidate vaccines have been well tolerated, with no acute or longer-term serious toxicity. Intramuscular multidose gp120 vaccines induce neutralizing antibodies, lymphoproliferative responses, and anti-HIV-1 CD4 cytotoxic T cell (CTL) activity. Immunization with the vaccinia-env construct, followed by a boost with an envelope protein, also induces neutralizing antibodies, and anti-HIV-1 CTL activity (CD8, major histocompatibility complex class I-restricted) has been observed. To date, serum from vaccinees can neutralize laboratory-adapted HIV-1 strains in vitro but not primary isolates; the significance of this observation is unknown. Additional approaches to vaccination against HIV-1 are in development.