gebhart/patrepeval huggingface dataset:
Kaiser Permanente's Convergent Medical Terminology. (2004)

This paper describes Kaiser Permanente's (KP) enterprise-wide medical terminology solution, referred to as our Convergent Medical Terminology (CMT). Initially developed to serve the needs of a regional electronic health record, CMT has evolved into a core KP asset, serving as the common terminology across all applications. CMT serves as the definitive source of concept definitions for the organization, provides a consistent structure and access method to all codes used by the organization, and is KP's language of interoperability, with cross-mappings to regional ancillary systems and administrative billing codes. The core of CMT is comprised of SNOMED CT, laboratory LOINC, and First DataBank drug terminology. These are integrated into a single poly-hierarchically structured knowledge base. Cross map sets provide bi-directional translations between CMT and ancillary applications and administrative billing codes. Context sets provide subsets of CMT for use in specific contexts. Our experience with CMT has lead us to conclude that a successful terminology solution requires that: (1) usability considerations are an organizational priority; (2) "interface" terminology is differentiated from "reference" terminology; (3) it be easy for clinicians to find the concepts they need; (4) the immediate value of coded data be apparent to clinician user; (5) there be a well defined approach to terminology extensions. Over the past several years, there has been substantial progress made in the domain coverage and standardization of medical terminology. KP has learned to exploit that terminology in ways that are clinician-acceptable and that provide powerful options for data analysis and reporting.
Registration of ‘Jazzman‐2’ Aromatic Long‐Grain Rice (2012)

‘Jazzman‐2’ (Reg. No. CV‐139, PI 663188) is the second jasmine‐type long‐grain aromatic rice ( Oryza sativa L.) cultivar, which was developed using the pedigree selection by the Rice Research Station, Louisiana State University Agricultural Center near Crowley, LA. It was approved for official release by the director of the Louisiana Agricultural Experiment Station in 2010 based on its strong aroma, slender and translucent grain, fair yield potential, and good milling quality. In 28 yield trials conducted at five Louisiana locations and in five southern rice growing states during 2006–2010, Jazzman‐2 had an average main crop grain yield of 7.39 t ha −1 , which was lower than that of ‘Jazzman’ (7.93 t ha −1 ) and the nonaromatic check ‘Cheniere’ (8.98 t ha −1 ). Jazzman‐2 is similar to Cheniere in plant height but is 10 cm shorter than Jazzman. The average number of days from emergence to 50% heading is 83, 85, and 87 for Jazzman‐2, Cheniere, and Jazzman. Jazzman‐2 has a commercially acceptable head rice yield of 639 g kg −1 , which is similar to the 633 and 630 g kg −1 of Jazzman and Cheniere. Jazzman‐2 has the typical jasmine‐rice cooking quality with low amylose content, low gelatinization temperature, and a very strong aroma. The average amylose content of Jazzman‐2 is 14.4% compared with 15.7 and 24.2% for Jazzman and Cheniere. The average alkali spread value of Jazzman‐2, Jazzman, and Cheniere is 6.0, 6.4, and 4.4. Jazzman‐2 has an average 2‐acetyl‐pyrroline content of 833 ng g −1 , which is significantly higher than the 482 ng g −1 of Jazzman. Naming the new cultivar Jazzman‐2 is based on the fact that both Jazzman‐2 and Jazzman share the similar unique cooking quality and also for branding purposes. Jazzman‐2 will complement the original Jazzman by offering more choices to rice growers, processors, and consumers with its earliness, short stature, and enhanced specialty attributes.
Microarray scanner calibration curves: characteristics and implications (2005)

It is preferable to scan microarray slides at fixed, optimal gain settings under which the linearity between concentration and intensity is maximized. Although normalization methods improve reproducibility of microarray measurements, they appear less effective in improving accuracy.
Interactions Between Mastoparan B and the Membrane Studied by<sup>1</sup>H NMR Spectroscopy (2001)

Mastoparan B (MP-B) is an antimicrobial cationic tetradecapeptide amide isolated from the venom of the hornet Vespa basalis. NMR spectroscopy was used to study the membrane associated structures of MP-B in various model membrane systems such as 120 mM DPC micelles, 200 mM SDS micelles, and 3%(w/v) DMPC/DHPC (1:2) bicelles. In all systems, MP-B has an amphiphilic alpha-helical structure from Lys2 to Leu14. NOESY experiments performed on MP-B in nondeuterated SDS micelles show that protons in the indole ring of Trp9 are in close contact with methylene protons of SDS micelles. T1 relaxation data and NOE data revealed that the bound form of MP-B may be dominant in SDS micelles. The interactions between MP-B and zwitterionic DPC micelles were much weaker than those between MP-B and anionic SDS micelles. By substitution of Trp9 with Ala9, the pore-forming activity of MP-B was decreased dramatically. All of these results imply that strong electrostatic interactions between the positively charged Lys residues in MP-B and the anionic phospholipid head groups must be the primary factor for MP-B binding to the cell membrane. Then, insertion of the indole ring of Trp9 into the membrane, as well as the amphiphilic alpha-helical structures of MP-B may allow MP-B to span the lipid bilayer through the C-terminal portion. These structural features are crucial for the potent antibiotic activities of MP-B.
Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication (2016)

The hepatitis B virus (HBV) regulatory protein X (HBx) activates gene expression from the HBV covalently closed circular DNA (cccDNA) genome. Interaction of HBx with the DDB1-CUL4-ROC1 (CRL4) E3 ligase is critical for this function. Using substrate-trapping proteomics, we identified the structural maintenance of chromosomes (SMC) complex proteins SMC5 and SMC6 as CRL4(HBx) substrates. HBx expression and HBV infection degraded the SMC5/6 complex in human hepatocytes in vitro and in humanized mice in vivo. HBx targets SMC5/6 for ubiquitylation by the CRL4(HBx) E3 ligase and subsequent degradation by the proteasome. Using a minicircle HBV (mcHBV) reporter system with HBx-dependent activity, we demonstrate that SMC5/6 knockdown, or inhibition with a dominant-negative SMC6, enhance HBx null mcHBV-Gluc gene expression. Furthermore, SMC5/6 knockdown rescued HBx-deficient HBV replication in human hepatocytes. These results indicate that a primary function of HBx is to degrade SMC5/6, which restricts HBV replication by inhibiting HBV gene expression.
Abstract B133: Antitumor effects of novel high-hydrophilic and non-ATP-competitive MEK1/2 inhibitor SMK-17. (2011)

Abstract The mitogen-activated protein kinase (MAPK) signal pathway plays a central role in regulating tumor cell proliferation, survival, and differentiation. The components of this pathway, Ras/Raf/MEK/ERK, are frequently activated in human cancers. Targeting this pathway is considered to be a promising anticancer strategy. In particular, MEK is an attractive drug target due to its high selectivity to ERK. We can expect potent growth inhibitory and proapoptotic effects by inhibiting MEK. We synthesized derivatives of N-[2-(2-Chloro-4-iodo-phenylamino)-3,4-difluorophenyl] -methanesulfonamide as novel MEK1/2 inhibitors. Among these compounds, we found SMK-17 to be a potent MEK1/2 inhibitor with high aqueous solubility. The in silico docking study suggested that SMK-17 be bound to an allosteric pocket of MEK1. The kinetics study and kinase profiler analysis confirmed the allosteric character of SMK-17. SMK-17 inhibited MEK1 kinase activity by a non-ATP-competitive manner and it was highly selective to MEK1 and 2. SMK-17 inhibited the growth of tumor cell lines in vitro. Especially, it seemed that cell lines harboring highly phosphorylated MEK1/2 and ERK1/2 were highly sensitive to SMK-17. Moreover, unlike previously reported MEK inhibitors, PD184352 or U0126, SMK-17 did not inhibit phosphorylation of ERK5. In vivo, SMK-17 exhibited potent antitumor activity in animal models by oral administration. SMK-17 selectively blocked the MAPK pathway signaling without affecting other signal pathways, which resulted in significant antitumor efficacy without notable side effects. In conclusion, we found very potent MEK inhibitor SMK-17 from our structure-activity correlation study of new derivative series of diphenyl amine sulfonamide. Kinase profiler and kinetics study revealed that SMK-17 is a non-ATP-competitive and highly selective MEK1/2 inhibitor. Moreover, SMK-17 exhibited potent antitumor activity in animal models by oral administration. SMK-17 selectively blocked the MAPK pathway signaling without affecting other signal pathways both in vitro and in vivo. These findings suggest that SMK-17 is a useful chemical biology tool for characterizing the function of MEK/MAPK signaling. Furthermore, we are now investigating the combination effects of SMK-17 with several drugs, and studying about prediction marker of this compound. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B133.
Purification of the Main Ginsenosides from a French Crop of<i>Panax Quinquefolium</i>L. (1995)

International audience
The lepidopteran transposon vector, <i>piggyBac</i> , mediates germ-line transformation in the Mediterranean fruit fly (1998)

The piggyBac (IFP2) short inverted terminal repeat transposable element from the cabbage looper Trichoplusia ni was tested for gene transfer vector function as part of a bipartite vector-helper system in the Mediterranean fruit fly Ceratitis capitata. A piggyBac vector marked with the medfly white gene was tested with a normally regulated piggyBac transposase helper at two different concentrations in a white eye host strain. Both experiments yielded transformants at an approximate frequency of 3-5%, with a total of six lines isolated having pigmented eyes with various levels of coloration. G1 transformant siblings from each line shared at least one common integration, with several sublines having an additional second integration. For the first transformant line isolated, two integrations were determined to be stable for 15 generations. For five of the lines, a piggyBac-mediated transposition was verified by sequencing the insertion site junctions isolated by inverse PCR that identified a characteristic piggyBac TTAA target site duplication. The efficient and stable transformation of the medfly with a lepidopteran vector represents transposon function over a relatively large evolutionary distance and suggests that the piggyBac system will be functional in a broad range of insects.
Toward a practice of autonomous systems (1992)

Autonomous robots - Swarm intelligence - Learning and evolution - Adaptive and evolutionary mechanisms - Epistemological issues and conceptual foundations.
Development of an automated speech recognition interface for personal emergency response systems (2009)

The use of an automated dialog-based PERS has the potential to provide users with more autonomy in decisions regarding their own health and more privacy in their own home.
Empirical Evaluation of a New Method for Calculating Signal-to-Noise Ratio for Microarray Data Analysis (2008)

Signal-to-noise-ratio (SNR) thresholds for microarray data analysis were experimentally determined with an oligonucleotide array that contained perfect-match (PM) and mismatch (MM) probes based upon four genes from Shewanella oneidensis MR-1. A new SNR calculation, called the signal-to-both-standard-deviations ratio (SSDR), was developed and evaluated, along with other two methods, the signal-to-standard-deviation ratio (SSR) and the signal-to-background ratio (SBR). At a low stringency, the thresholds of the SSR, SBR, and SSDR were 2.5, 1.60, and 0.80 with an oligonucleotide and a PCR amplicon as target templates and 2.0, 1.60, and 0.70 with genomic DNAs as target templates. Slightly higher thresholds were obtained under high-stringency conditions. The thresholds of the SSR and SSDR decreased with an increase in the complexity of targets (e.g., target types) and the presence of background DNA and a decrease in the compositions of targets, while the SBR remained unchanged in all situations. The lowest percentage of false positives and false negatives was observed with the SSDR calculation method, suggesting that it may be a better SNR calculation for more accurate determination of SNR thresholds. Positive spots identified by SNR thresholds were verified by the Student t test, and consistent results were observed. This study provides general guidance for users to select appropriate SNR thresholds for different samples under different hybridization conditions.
Near-field interrogation of SAW resonators on rotating machinery (2013)

Abstract. Surface acoustic wave (SAW) resonators electrically behave like LCR circuits, their frequency can be influenced by temperature, pressure and torque. When they are used for passive wireless sensing on rotating machinery, they can also be influenced by the angular variations of the coupling between the coupler elements and the receiving coupler element impedance. This parasitic frequency shift is known as the "pulling effect". In this paper, we present a capacitive coupler based on open coplanar strip lines for physical measurements on a small diameter rotating shaft. This approach allows a single 434 MHz resonator angular frequency pulling lower than 200 Hz (0.46 ppm) and 100 Hz (0.23 ppm) in a differential configuration. This is more than 10 times lower compared to frequency pulling obtained using couplers based on circular and electrically shorted transmission lines. RADAR-based interrogation, finite element method (FEM) simulation, coupler parameters and frequency pulling measurements results are presented to demonstrate the performances of the complete system.
(+)‐Asteriscanolide (Paquette 2000) (2001)

The sesquiterpene (+)-asteriscanolide 1 was first isolated from Asteriscus aquaticus L and characterized by San Feliciano in 1985.1 It has captured the attention of organic chemists mainly because of its uncommon bicyclo[6.3.0]undecane ring system bridged by a butyrolactone fragment. This problem is based on the work of Paquette published in 2000.4
Lanthanum oxide-based catalysts for the Claus process (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLanthanum oxide-based catalysts for the Claus processJoseph A. Baglio, Thomas J. Susa, David W. Wortham, Elizabeth A. Trickett, and Thomas J. LewisCite this: Ind. Eng. Chem. Prod. Res. Dev. 1982, 21, 3, 408–415Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://pubs.acs.org/doi/10.1021/i300007a011https://doi.org/10.1021/i300007a011research-articleACS PublicationsRequest reuse permissionsArticle Views174Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
ABI5 acts downstream of ABI3 to execute an ABA‐dependent growth arrest during germination (2002)

The development of a germinating embryo into an autotrophic seedling is arrested under conditions of water deficit. This ABA-mediated developmental checkpoint requires the bZIP transcription factor ABI5. Here, we used abi3-1, which is also unable to execute this checkpoint, to investigate the relative role of ABI3 and ABI5 in this process. In wild-type Arabidopsis plants, ABI3 expression and activity parallel those described for ABI5 following stratification. During this process, transcript levels of late embryogenesis genes such as AtEm1 and AtEm6 are also re-induced, which might be responsible for the acquired osmotic tolerance in germinated embryos whose growth is arrested. ABI5 expression is greatly reduced in abi3-1 mutants, which has low AtEm1 or AtEm6 expression. Cross complementation experiments showed that 35S-ABI5 could complement abi3-1, whereas 35S-ABI3 cannot complement abi5-4. These results indicate that ABI5 acts downstream of ABI3 to reactivate late embryogenesis programmes and to arrest growth of germinating embryos. Although ABI5 is consistently located in the nucleus, chromosomal immunoprecipitation (ChIP) experiments revealed that ABA increases ABI5 occupancy on the AtEm6 promoter.
A novel approach to data deduplication over the engineering-oriented cloud systems (2013)

This paper presents a duplication-less storage system over the engineering-oriented cloud computing platforms. Our deduplication storage system, which manages data and duplication over the cloud system, consists of two major components, a front-end d
Adaptive camera assignment and hand-off algorithm in multiple active camera surveillance system (2010)

Recently, the pan-tilt-zoom (PTZ) camera is extensively used for surveillance in wide area environments. A current automatic system has been developed to continually track a person with the function of keeping the person centered in the field of view (FOV). Tracking moving objects has long been a key problem in computer vision. It is important in a wide variety of video surveillance applications and has been applied successfully in people's daily life, like human motion analysis, traffic monitoring, market guard, and in-house health care. When multiple cameras are used for tracking, the algorithm can automatically provide an optimal capacity and provide a solution to perform the camera assignment efficiently. This paper investigates the application of automatic methods for tracking individual across cameras via a surveillance network. Our approach is to track the individual and activate the function of surveillance in cameras to achieve seamless tracking with high quality image. We develop an emerging low computational complexity hand-off function that can automatically carry out the camera assignment and hand-off task. In the experiment, with a feasible solution for seamless tracking and real-time surveillance provided, our algorithm can perform the hand-off task efficiently and automatically in multiple active camera surveillance systems.
Global Collaboration Benefits Textile Research (1999)

Textile scientist Anil Netravali and researchers at Kyoritsu Women's University in Japan are working to develop stronger, more durable synthetic fibers and fabrics. An agreement of collaboration between the two universities has allowed the researchers-and their students-to learn from each other. It's the first Monday of the Wimbledon fortnight. When Anil Netravali is asked to illustrate the ubiquitousness of composite materials, the first word out of his mouth is tennis. The tennis ball's furry covering, he's quick to say, is made of a fibrous material. So are the racket strings, woven though a frame - made of 50 percent graphite fibers held together by epoxy - that is light yet strong enough that 90-miles-per-hour serves are commonplace. Were the Wimbledon courts not grass, the players would be running on fibers too, for asphalt courts (and the highways players use to get to them) sit on a layer of geotextiles that promotes water drainage, thus reducing potholes. Around the globe, elite athletes, and the rest of us, rely on composite materials - fibers of some type bonded in a matrix of some type of polymer, and more commonly known as plastic. Sutures and circuit boards, bulletproof vests and racing bicycles, the bodies of automobiles and the shafts of golf clubs - all are made of composites. Their main virtue is offering great strength with very little weight. In a composite material it's the fibers that bear the load. For the fibers to do so, they must be bonded together extremely well. Netravali, an associate professor of textiles and apparel who joined the faculty in 1987, is an expert in using radiation to modify the surface characteristics of fibers - their chemistry or topography - in order to make those bonds stronger. So when Tetsuya Sakai, a professor in the textiles program from the Kyoritsu Women's University (KWU) in Tokyo, Japan, was looking for a collaborator to investigate the effects of high-energy radiation (such as gamma and UV) on polyamide fibers, Netravali was a likely choice. The first polyamide fiber, better known as nylon, was invented by the E. I. du Pont de Nemours & Co. in the 1930s. This synthetic fiber is used today worldwide in everything from tire cords and women's stockings to carpets and netting for commercial fishing fleets. Yet as the owners of nylon carpet know only too well, nylon color fades when exposed to the sun. Radiation causes nylon to degrade in other ways as well, including a gradual loss of strength. In the next few years Netravali and Sakai - as part of an agreement of collaboration between the two colleges signed in 1998 by Dean Francille Firebaugh - will be working together to characterize the degradation of different types of polyamide fibers and fabrics as a function of the dose of various types of radiation. …
Expression of Ia and monocyte-macrophage lineage antigens in giant cell tumor of bone and related lesions. (1988)

An immunohistochemical study of six giant cell tumors of bone and eight related lesions (aneurysmal bone cyst, fibrous histiocytoma, and giant cell tumor of tendon sheath) was performed using a panel of monoclonal antibodies directed to the Ia and monocyte-macrophage lineage antigens. In all types of lesion, osteoclastlike multinucleate giant cells were negative for both types of antigen, but a proportion of mononuclear cells gave positive reactions. While the possibility that these cells are reactive cannot be excluded, in giant cell tumor and malignant fibrous histiocytoma, their frequency and their morphologic similarity to the rest of the tissue suggest that they may be an intrinsic part of the neoplasm. This finding is consistent with the presumed fibrohistiocytic nature of these tumors.
Fibre‐Optic Sensors (2007)

This chapter contains sections titled: Introduction to Fibre-Optic Technology Fibre-Optic Sensing Technologies Sensor Packaging Distributed Sensing Cables Software and System Integration Conclusions and Summary