gebhart/patrepeval huggingface dataset:
The Chlorination of Aromatic Hydrocarbons in Carbon Tetrachloride and in Trifluoroacetic Acid (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chlorination of Aromatic Hydrocarbons in Carbon Tetrachloride and in Trifluoroacetic AcidL. J. Andrews and R. M. KeeferCite this: J. Am. Chem. Soc. 1957, 79, 19, 5169–5174Publication Date (Print):October 1, 1957Publication History Published online1 May 2002Published inissue 1 October 1957https://pubs.acs.org/doi/10.1021/ja01576a024https://doi.org/10.1021/ja01576a024research-articleACS PublicationsRequest reuse permissionsArticle Views169Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spatiotemporal state lattices for fast trajectory planning in dynamic on-road driving scenarios (2009)

We present a method for motion planning in the presence of moving obstacles that is aimed at dynamic on-road driving scenarios. Planning is performed within a geometric graph that is established by sampling deterministically from a manifold that is obtained by combining configuration space and time. We show that these graphs are acyclic and shortest path algorithms with linear runtime can be employed. By reparametrising the configuration space to match the course of the road, it can be sampled very economically with few vertices, and this reduces absolute runtime further. The trajectories generated are quintic splines. They are second order continuous, obey nonholonomic constraints and are optimised for minimum square of jerk. Planning time remains below 20 ms on general purpose hardware.
Improved Energy Efficiency for Optical Transport Networks by Elastic Forward Error Correction (2014)

In this paper we propose a scheme for reducing the energy consumption of optical links by means of adaptive forward error correction (FEC). The scheme works by performing on the fly adjustments to the code rate of the FEC, adding extra parity bits to the data stream whenever extra capacity is available. We show that this additional parity information decreases the number of necessary decoding iterations and thus reduces the power consumption in iterative decoders during periods of low load. The code rate adjustments can be done on a frame-by-frame basis and thus make it possible to manipulate the balance between effective data rate and FEC coding gain without any disruption to the live traffic. As a consequence, these automatic adjustments can be performed very often based on the current traffic demand and bit error rate performance of the links through the network. The FEC scheme itself is designed to work as a transparent add-on to transceivers running the optical transport network (OTN) protocol, adding an extra layer of elastic soft-decision FEC to the built-in hard-decision FEC implemented in OTN, while retaining interoperability with existing OTN equipment. In order to facilitate dynamic code rate adaptation, we propose a programmable encoder and decoder design approach, which can implement various codes depending on the desired code rate using the same basic circuitry. This design ensures optimal coding gain performance with a modest overhead for supporting multiple codes with minimal impact on the area and power requirements of the decoder.
Molecular Characterization of Hepatitis A Virus Isolates from a Transcontinental Shellfish-Borne Outbreak (2002)

One hundred eighty-four serologically confirmed cases of hepatitis A were reported in eastern Spain in 1999. A matched case-control study implicated imported coquina clams complying with European Union shellfish standards as the source of infection; this implication was confirmed by the detection by reverse transcription-PCR of hepatitis A virus (HAV) RNA in shellfish samples. In spite of the recognized low variability of HAV, genetic characterization of the complete capsid region of virus isolates from patient serum samples revealed the existence of both synonymous and nonsynonymous variants. Two antigenic variants were detected, one in a discontinuous epitope defined by monoclonal antibody K3-4C8 and a second in a linear VP1 epitope of the virus. In spite of these antigenic variants, all isolates were assigned to genotype IB, providing further evidence that the outbreak originated from a common source, although multiple strains were likely to be involved.
Toll‐like receptor 3 agonist poly(I:C)‐induced antiviral response in human corneal epithelial cells (2005)

The objective of this study was to examine the expression of Toll-like receptor 3 (TLR3) by human corneal epithelial cells (HCECs) and to determine whether exposure to the TLR3 agonist polyinosinic-polycytidylic acid [poly(I:C)] induces an antiviral response in these cells. Fluorescence-activated cell sorter (FACS) analysis revealed TLR3 to be constitutively expressed and distributed intracellularly in HCECs. Stimulation of HCECs with the TLR3 agonist poly(I:C) induced the activation of nuclear factor (NF)-kappaB and production of the proinflammatory cytokine interleukin (IL)-6 and the chemokine IL-8. Upon exposure to poly(I:C), HCECs initiated a potent antiviral response resulting in an increase of interferon (IFN)-beta mRNA expression (7-fold). Poly(I:C) stimulation also up-regulated mRNA expression of the antiviral chemokine IFN-gamma inducible protein 10 (IP10), myxovirus resistance gene A and 2',5'-oligoadenylate synthetase (5-, 10- and 9-fold, respectively), and secretion of IP10. These responses were also induced by exogenously added type 1 IFNs, but could not be blocked by pretreatment of the cells with anti-TLR3 monoclonal antibody, suggesting that the receptor was not expressed on the cell surface. Furthermore, incubation of HCECs with an endosomal acidification inhibitor, chloroquine, markedly inhibited poly(I:C)-mediated IFN-beta expression in HCECs. These results suggest that corneal epithelial cells are important sentinels of the corneal innate immune system against viral infection, and that stimulation of TLR3 can induce the expression of key proinflammatory cytokines and chemokines and antiviral genes that help in the defence of the cornea against viral infection.
B-Raf and Raf-1 Are Regulated by Distinct Autoregulatory Mechanisms (2005)

B-Raf is a key regulator of the ERK pathway and is mutationally activated in two-thirds of human melanomas. In this work, we have investigated the activation mechanism of B-Raf and characterized the roles of Ras and of B-Raf phosphorylation in this regulation. Raf-1 is regulated by an N-terminal autoinhibitory domain whose actions are blocked by interaction with Ras and subsequent phosphorylation of Ser(338). We observed that B-Raf also contains an N-terminal autoinhibitory domain and that the interaction of this domain with the catalytic domain was inhibited by binding to active H-Ras. However, unlike Raf-1, the phosphorylation of B-Raf at Ser(445) was constitutive and was only moderately increased by expression of constitutively active H-Ras or constitutively active PAK1. Ser(445) phosphorylation is important to the B-Raf activation mechanism, however, because mutation of this site to alanine increased the affinity of the regulatory domain for the catalytic domain and increased autoinhibition. Similarly, expression of constitutively active PAK1 also decreased auto-inhibition. B-Raf autoinhibition was negatively regulated by acidic substitutions at phosphorylation sites within the activation loop of B-Raf and by the oncogenic substitution V599E. However, these substitutions did not affect the ability of the regulatory domain to co-immunoprecipitate with the catalytic domain. These data demonstrate that B-Raf activity is autoregulated, that constitutive phosphorylation of Ser(445) primes B-Raf for activation, and that a key feature of phosphorylation within the activation loop or of oncogenic mutations within this region is to block autoinhibition.
A HYBRID HELIX CONTAINING BOTH DEOXYRIBOSE AND RIBOSE POLYNUCLEOTIDES AND ITS RELATION TO THE TRANSFER OF INFORMATION BETWEEN THE NUCLEIC ACIDS (1960)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
A 5.58nW 32.768kHz DLL-assisted XO for real-time clocks in wireless sensing applications (2012)

There is a growing interest in ultra-low-power wireless microsystems [1]. Synchronization between different nodes in a wireless sensor network plays an important role in the overall node energy budget due to the high power demand of wireless communication. One synchronization approach is to employ a realtime clock (RTC) on each node, with nodes awakening periodically to communicate and re-synchronize. With recent work on ultra-low-power microsystems demonstrating average power consumption of several nW [2], there is a need for ultra-low-power timers that can synchronize communication events and serve as frequency references for radios.
Using Rank‐Order Geostatistics for Spatial Interpolation of Highly Skewed Data in a Heavy‐Metal Contaminated Site (2001)

The spatial distribution of a pollutant in contaminated soils is usually highly skewed. As a result, the sample variogram often differs considerably from its regional counterpart and the geostatistical interpolation is hindered. In this study, rank-order geostatistics with standardized rank transformation was used for the spatial interpolation of pollutants with a highly skewed distribution in contaminated soils when commonly used nonlinear methods, such as logarithmic and normal-scored transformations, are not suitable. A real data set of soil Cd concentrations with great variation and high skewness in a contaminated site of Taiwan was used for illustration. The spatial dependence of ranks transformed from Cd concentrations was identified and kriging estimation was readily performed in the standardized-rank space. The estimated standardized rank was back-transformed into the concentration space using the middle point model within a standardized-rank interval of the empirical distribution function (EDF). The spatial distribution of Cd concentrations was then obtained. The probability of Cd concentration being higher than a given cutoff value also can be estimated by using the estimated distribution of standardized ranks. The contour maps of Cd concentrations and the probabilities of Cd concentrations being higher than the cutoff value can be simultaneously used for delineation of hazardous areas of contaminated soils.
Synthesis of Resistive Tapers to Control Scattering Patterns of Strips. (1987)

This thesis outlines a technique for synthesizing a resistive taper that generates desired bistatic scattering and backscattering patterns from a strip. Antenna synthesis techniques relate the scattered field to the induced surface current density to get low sidelobes and nulls in the scattering patterns. Either physical optics or an integral equation approach relates the surface current density to the resistive taper. Numerical methods are used to analyze the errors in measuring a resistive taper on a sheet with the four-point probe. The impact of the manufacturing and resistivity measurement errors on the low sidelobe scattering patterns is examined. Finally, experimental bistatic scattering patterns of a tapered resistive sheet and a metal plate are compared with theoretical predictions.
An Analysis of Tire Traction Properties and Their Influence on Vehicle Dynamic Performance (1970)

<div class="htmlview paragraph">An analysis is made of the influence of tire-mechanics characteristics on the behavior of an automobile undergoing maneuvers requiring the tires to produce combined longitudinal and lateral forces. The mathematical model employed to represent the vehicle incorporates wheel rotational degrees of freedom and relationships expressing the longitudinal and lateral tire shear force components as analytical functions of tire normal load, sideslip and inclination angles, and longitudinal slip.</div> <div class="htmlview paragraph">The tire shear force relationships, derived by extrapolating from existing theory for the traction mechanics of a freely rolling tire, agree qualitatively with available experimental data. Analog simulation results are examined to assess the influence on vehicle steering/braking response of variations of three parameters: lateral tire stiffness, longitudinal tire stiffness, and the coefficient of friction at the tire/road interface.</div>
Electrochemical printing: software reconfigurable electrochemical microfabrication (2005)

Electrochemical printing (EcP) is a software reconfigurable tool and process for electrodeposition of multi-scale, multi-material objects from input drawings. The EcP system—comprising custom LabVIEW print driver software, hardware, electrolyte and a microjet print nozzle—creates complex patterns by locally electroplating individual metal and alloy dots as the microjet rasters over a substrate. The rastering of a microjet just a few microns above the substrate provides extraordinary convective mass transfer rates, allowing material growth rates that are routinely two orders of magnitude greater than in conventional plating. EcP has the flexibility to vary the print resolution and material composition during the patterning process via real time control of the microjet fly height, electrolyte flow rate and applied current. Microjet fly-height is used to vary the print resolution from 50 to 1000 dots per inch during the printing of a copper pattern. Simultaneous control of electrolyte flow rate and applied current through the microjet nozzle is used to achieve high plating efficiencies, well-formed dots and alloys of specific compositions for the copper and nickel–copper systems. It is also shown that commercially available noble metal plating baths can be used in the EcP tool, despite the unusually large current densities achievable and the complexity of commercial bath additives. Issues associated with making EcP a robust tool for 2D and 3D microfabrication are discussed.
Effects of <i>Lactobacillus Salivarius</i> LS01 (DSM 22775) Treatment on Adult Atopic Dermatitis: A Randomized Placebo-Controlled Study (2011)

Atopic dermatitis (AD) is a common inflammatory skin disease characterized by xerosis, pruritus and eczema. The role of probiotics in the prevention and the treatment of AD have been extensively studied in children with controversial results while there are few studies on an adult population. The aim of this randomized, double-blind, placebo-controlled study is to evaluate the clinical efficacy of the intake of a probiotic strain (Lactobacillus salivarius LS01) in the treatment of adult patients with AD. A group of 38 patients was treated with probiotics or placebo (maltodextrin) for 16 weeks. The study was performed from January (T0) to May, 2009 (T16). The assessment of efficacy was based on change in SCORAD (SCORing Atopic Dermatitis) index, dermatology life quality index (DLQI) improvement, cytokine production by PBMCs and ability to modify faecal microbial flora. No significant adverse events were recorded during the study. Patients treated with probiotics showed a statistically improvement of both clinical parameters (SCORAD p<0.0001 and DLQI p= 0.021) at the end of treatment (T16) compared with the placebo group. Furthermore, after four months of treatment there was a significant reduction of Th1 cytokines (IL-12+IFNgamma) (p= 0.03) and Th1/Th2 ratio (IL-12+IFNgamma/IL-4+IL-5) (p= 0.019) only in placebo-treated patients. A statistically relevant decrease of staphylococci in faeces of the probiotictreated group was also observed at the end of treatment. In our study, the administration of L. salivarius LS01 was well tolerated and was associated with a significant improvement of clinical manifestation and QoL. This probiotic strain could have an important role in modulating Th1/Th2 cytokine profiles and could be considered as an important adjunctive therapy in the treatment of adult AD.
Growth hormone, IGF‐I and insulin and their abuse in sport (2008)

There is widespread anecdotal evidence that growth hormone (GH) is used by athletes for its anabolic and lipolytic properties. Although there is little evidence that GH improves performance in young healthy adults, randomized controlled studies carried out so far are inadequately designed to demonstrate this, not least because GH is often abused in combination with anabolic steroids and insulin. Some of the anabolic actions of GH are mediated through the generation of insulin-like growth factor-I (IGF-I), and it is believed that this is also being abused. Athletes are exposing themselves to potential harm by self-administering large doses of GH, IGF-I and insulin. The effects of excess GH are exemplified by acromegaly. IGF-I may mediate and cause some of these changes, but in addition, IGF-I may lead to profound hypoglycaemia, as indeed can insulin. Although GH is on the World Anti-doping Agency list of banned substances, the detection of abuse with GH is challenging. Two approaches have been developed to detect GH abuse. The first is based on an assessment of the effect of exogenous recombinant human GH on pituitary GH isoforms and the second is based on the measurement of markers of GH action. As a result, GH abuse can be detected with reasonable sensitivity and specificity. Testing for IGF-I and insulin is in its infancy, but the measurement of markers of GH action may also detect IGF-I usage, while urine mass spectroscopy has begun to identify the use of insulin analogues.
Rapid Shortening of Telomere Length in Response to Ceramide Involves the Inhibition of Telomere Binding Activity of Nuclear Glyceraldehyde-3-phosphate Dehydrogenase (2004)

Ceramide has been demonstrated as one of the upstream regulators of telomerase activity. However, the role for ceramide in the control of telomere length remains unknown. It is shown here that treatment of the A549 human lung adenocarcinoma cells with C(6)-ceramide results in rapid shortening of telomere length. During the examination of ceramide-regulated telomere-binding proteins, nuclear glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was identified to associate with both single- and double-stranded telomeric DNA with high specificity in vitro. The association of nuclear GAPDH with telomeres in interphase nuclei was also demonstrated by co-fluorescence in situ hybridization and chromatin immunoprecipitation analysis. Further data demonstrated that the nuclear localization of GAPDH is regulated by ceramide in a cell cycle-dependent manner parallel with the inhibition of its telomere binding activity in response to ceramide. In addition, the results revealed that nuclear GAPDH is distinct from its cytoplasmic isoform and that telomere binding function of nuclear GAPDH is strikingly higher than the cytoplasmic isoform. More importantly, the functional role for nuclear GAPDH in the maintenance and/or protection of telomeric DNA was identified by partial inhibition of the expression of GAPDH using small interfering RNA, which resulted in rapid shortening of telomeres. In contrast, overexpression of nuclear GAPDH resulted in the protection of telomeric DNA in response to exogenous ceramide as well as in response to anticancer drugs, which have been shown to induce endogenous ceramide levels. Therefore, these results demonstrate a novel function for nuclear GAPDH in the maintenance and/or protection of telomeres and also show that mechanisms of the rapid degradation of telomeres in response to ceramide involve the inhibition of the telomere binding activity of nuclear GAPDH.
Uncooled Lasers for Deployment of Fiber in the Loop (1993)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. E. ZAH, R. BHAT, T. P. LEE, Z. WANG, D. DARBY, D. FLANDERS, and J. J. HSIEH, "Uncooled Lasers for Deployment of Fiber in the Loop," Optics & Photonics News 4(12), 25-25 (1993) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Ernst Stracke, Luthers großes Selbstzeugnis 1545 über seine Entwicklung zum Reformator, historisch - kritisch untersucht. Wilhelm Stolze, Bauernkrieg und Reformation. (1928)

Article Ernst Stracke, Luthers großes Selbstzeugnis 1545 über seine Entwicklung zum Reformator, historisch - kritisch untersucht. Wilhelm Stolze, Bauernkrieg und Reformation. was published on August 1, 1928 in the journal Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Kanonistische Abteilung (volume 17, issue 1).
HIV/AIDS business coalitions: guidelines for building business coalitions against HIV/AIDS (2004)

HIV/AIDS undermines the social and economic fabrics of societies. Beyond the human tragedies, HIV/AIDS degrades the health and education of a nation's citizenry. Current and future workforces are at an increasingly higher risk, as the epidemic disproportionately affects people during their most productive years. HIV/AIDS can increase the costs of doing business and reduce the long-term business potential of markets. It can also impact the investment environment and inflows of foreign capital. As a vital part of society, businesses are increasingly responding to the epidemic. Some respond from a sense of enlightened self-interest and corporate social responsibility.
Thermal analysis of Ga-In-Sn system (1978)

AbstractAbstractThermal analysis has been used to determine the liquidus and characterize the reactions in the Ga-In- Sn system. A reaction of the type liq + (In) ⇄ β >+ (Ga) was shown to occur at 13°C, and the ternary eutectic reaction liq ⇄ (Ga)+β+(Sn) at 10.7±0.3°C. A quasi-peritectic reaction liq +γ ⇄ β + (Sn) is postulated but was pot located experimentally: it is believed to occur in alloys containing less than 1 wt-% Ga with a reaction temperature above 110°C. A quasi-peritectoid reaction β + (Sn) = (Ga) + γ is also postulated. The ternary eutectic occurs at the composition 66.0Ga-20.5In-13.5 wt-%Sn.
Visual Reverse Turing Tests: A False Sense of Security (2006)

Internet services are increasingly abused by malicious scripts that try to mimic human users. Reverse Turing tests are challenges used to differentiate humans from computers. Visual reverse Turing tests use visual challenges, such as distorted character recognition tasks, that are easily solved by humans, while remaining too hard for automatic scripts. We demonstrate that the computational and development cost of a script breaking through some currently deployed visual reverse Turing tests is low, thus making them ineffective in protecting these services. We present two case studies of successful attacks on character-based tests that are currently used to protect two public Web services. Our attacks utilize image processing techniques and also exploit flaws in the test deployment