gebhart/patrepeval huggingface dataset:
Generic Architecture for Cloud Infrastructure as a Service (IaaS) Provisioning Model Release 1 (2011)

This document provides information about the proposed architectural framework for Cloud Infrastructure as a Service (IaaS) provisioning model that includes the following components: the Composable Services Architecture (CSA) that intends to provide a conceptual and methodological framework for developing dynamically configurable virtualised infrastructure services; the Infrastructure Services Modeling Framework (ISMF) that provides a basis for the infrastructure resources virtualisation and management, including description, discovery, modeling, composition and monitoring; the Service Delivery Framework (SDF) that provides a basis for defining the whole composable services life cycle management and supporting infrastructure services. The document intends to provide a starting point for further discussion and possible coordination with other project developments and standardisation activities. This development has been facilitated by a number of the projects and activities in which the SNE Group at the University of Amsterdam takes active part, in particular projects GEYSERS, GEANT3 JRA3 Composable Services, NOVI, SURFnet e-Science, and Open Grid Forum Research Group on Infrastructure Services On-Demand provisioning (ISOD-RG).
Organometallic route to the chemical vapor deposition of titanium carbide films at exceptionally low temperatures (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganometallic route to the chemical vapor deposition of titanium carbide films at exceptionally low temperaturesGregory S. Girolami, James A. Jensen, Deborah M. Pollina, Clare M. Allocca, Alain E. Kaloyeros, and Wendell S. WilliamsCite this: J. Am. Chem. Soc. 1987, 109, 5, 1579–1580Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://pubs.acs.org/doi/10.1021/ja00239a053https://doi.org/10.1021/ja00239a053research-articleACS PublicationsRequest reuse permissionsArticle Views488Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Differential Expression of the Small-Conductance, Calcium-Activated Potassium Channel SK3 Is Critical for Pacemaker Control in Dopaminergic Midbrain Neurons (2001)

The physiological activity of dopaminergic midbrain (DA) neurons is important for movement, cognition, and reward. Altered activity of DA neurons is a key finding in schizophrenia, but the cellular mechanisms have not been identified. Recently, KCNN3, a gene that encodes a member (SK3) of the small-conductance, calcium-activated potassium (SK) channels, has been proposed as a candidate gene for schizophrenia. However, the functional role of SK3 channels in DA neurons is unclear. We combined patch-clamp recordings with single-cell RT-PCR and confocal immunohistochemistry in mouse midbrain slices to study the function of molecularly defined SK channels in DA neurons. Biophysical and pharmacological analysis, single-cell mRNA, and protein expression profiling strongly suggest that SK3 channels mediate the calcium-dependent afterhyperpolarization in DA neurons. Perforated patch recordings of DA neurons in the substantia nigra (SN) demonstrated that SK3 channels dynamically control the frequency of spontaneous firing. In addition, SK3 channel activity was essential to maintain the high precision of the intrinsic pacemaker of DA SN neurons. In contrast, in the ventral tegmental area, DA neurons displayed significantly smaller SK currents and lower SK3 protein expression. In these DA neurons, SK3 channels were not involved in pacemaker control. Accordingly, they discharged in a more irregular manner compared with DA SN neurons. Thus, our study shows that differential SK3 channel expression is a critical molecular mechanism in DA neurons to control neuronal activity. This provides a cellular framework to understand the functional consequences of altered SK3 expression, a candidate disease mechanism for schizophrenia.
Fuel Efficient Lubricant Formulations for Passenger Cars or Heavy Duty Trucks (2000)

<div class="htmlview paragraph">For environmental and economical reasons, reduction of fuel consumption is becoming a major concern for car and truck manufacturers and customers. Analysis of consumer way of using their cars indicates, that it is by working on low temperature and low engine rotating speed that benefits given by the lubricant can be optimized. Analysis of customers way of using their trucks indicates that the engine is mainly working at stabilized temperature, in hydrodynamic conditions; in such conditions (for exemple highway), the reduction of fuel consumption coming from the engine lubricant is rather low, compared with passenger car applications.</div> <div class="htmlview paragraph">On that basis, specific rig tests have been developed to help the lubricant formulator. Each of these tests is specifically designed, for different engine friction area study: valve train, rings/liner, crankshaft bearings. The correlation between engine friction on each area and fuel consumption reduction is discussed. The influence of lubricant formulation on friction reduction is studied with these rig tests.</div> <div class="htmlview paragraph">For passenger car applications, the best compromise with the respect of API and ACEA specifications is obtained with a 5W-30 formulation, which gives a significant global engine friction reduction compared with current products. Evolution of fuel efficiency properties with lubricant ageing during drain intervals is discussed after field tests on engine test observation.</div> <div class="htmlview paragraph">For heavy duty truck application, the best way with the respect of API, ACEA and truck manufacturer specifications is obtained by a set of three lubricants (engine + gear box + rear axle), which gives an attractive reduction of fuel consumption.</div>
Preparation of Vitamin E Using Cation Exchange Resin Complexes of Metal Ions (1977)

Abstract A series of cation exchange resin complexes of metal ions were prepared. These resins are effective catalysts for the preparation of vitamin E and were recycled for use several times with little activity loss. The effect of solvents and metal ions on the reaction is discussed.
Susceptibility to adjuvant arthritis in da and F<sub>344</sub> RATS. A dominant trait controlled by an autosomal gene locus linked to the major histocompatibility complex (1982)

The hereditary of adjuvant-induced arthritis in rats of the DA and Fisher 344 strains was examined. Development of arthritic lesions in response to a single injection of supplemented Freund's complete adjuvant has been found to be controlled by an autosomal, dominant gene locus, Ar. The capacity to respond was present in DA rats and absent in our Fisher rats. Ar has been found to be linked to the major histocompatibility complex genes with which it exhibits a high rate of recombination.
Oncogenic Driver Mutations: Neither Tissue-Specific nor Independent (2013)

Genomic analysis of 12 cancers identifies common somatic mutations across tumor types.
Integrated Magnetic Bead–Quantum Dot Immunoassay for Malaria Detection (2017)

Malaria persists as a disease of high morbidity and mortality due to improper diagnosis, overuse of drugs, rapidly evolving drug resistant parasites, and poor disease monitoring. The two common tests used in developing countries, microscopic examination of Glemsa slides and rapid diagnostic tests (RDTs), have limitations associated with variability in specificity and sensitivity, and qualitative outcome. Here we report on an immunoassay using magnetic beads for capture and quantum dots for detection of histidine-rich protein 2 (HRP2). Conventional immunoassays, such as ELISA, and molecular analysis tools, such as PCR, are difficult to implement in low resource settings. Therefore, to provide a proof-of-principle of translation of this assay to low resource settings, we demonstrate HRP2 detection in an automated droplet-based microfluidic device. Droplet-based platforms have the potential to allow translation of molecular detection assays to point-of-care use in low resource settings.
Evaluating Influence Diagrams (1986)

An influence diagram is a graphical structure for modeling uncertain variables and decisions and explicitly revealing probabilistic dependence and the flow of information. It is an intuitive framework in which to formulate problems as perceived by decision makers and to incorporate the knowledge of experts. At the same time, it is a precise description of information that can be stored and manipulated by a computer. We develop an algorithm that can evaluate any well-formed influence diagram and determine the optimal policy for its decisions. Since the diagram can be analyzed directly, there is no need to construct other representations such as a decision tree. As a result, the analysis can be performed using the decision maker's perspective on the problem. Questions of sensitivity and the value of information are natural and easily posed. Modifications to the model suggested by such analyses can be made directly to the problem formulation, and then evaluated directly.
Clinical pharmacology of vasodilators. (1979)

Theodore Roosevelt Jr. with Claudine Spreckels, daughter of Rudolph Spreckels, the owner of the house Roosevelt rented in San Francisco.
Shorted, folded planar monopole antenna for dual-band mobile phone (2003)

A novel shorted, folded planar monopole antenna for application in GSM/DCS dual-band mobile phones is proposed. The antenna is easily fabricated from stamping a single metal plate, which is then folded onto a foam base of compact size 5×10×40 mm3. In addition, the proposed antenna shows a very low profile of 5 mm protruded from the top edge of the system ground plane, making it very promising to be employed within the casing of a mobile phone as an internal antenna.
Prediction of protein structure: The problem of fold multiplicity (1999)

Three-dimensional (3D) models of four CASP3 targets were calculated using a simple modeling procedure that includes prediction of regular secondary structure, analysis of possible beta-sheet topologies, assembly of amphiphilic helices and beta-sheets to bury their nonpolar surfaces, and adjustment of side-chain conformers and loops to provide close packing and saturation of the "hydrogen bond potential" (exposure of all polar groups to water or their involvement in intramolecular hydrogen bonds). It has been found that this approach allows construction of 3D models that, in some cases, properly reproduce the structural class of the protein (such as beta-barrel or beta-sandwich of definite shape and size) and details of tertiary structure (such as pairing of beta-strands), although all four models were more or less incorrect. Remarkably, some models had fewer water-exposed nonpolar side-chains, more hydrogen bonds, and smaller holes than the corresponding native structures (although the models had a larger water-accessible nonpolar surface). The results obtained indicate that hydrophobicity patterns do not unequivocally determine protein folds, and that any ab initio or fold recognition methods that operate with imprecise potential energy functions, or use crude geometrical approximations of the peptide chain, will probably produce many different nonnative structures.
Use of a ReO<sub>3</sub> Single Crystal as the Tip for Scanning Tunneling Microscopy (1991)

A corner of a ReO 3 single crystal was used as the tip for scanning tunneling microscopy (STM). The atomic arrays of graphite and ReO 3 were easily observed. The image of the emissive area is round in the former and polygonal in the latter, reflecting, perhaps, the electron distribution in the uppermost band.
Effect of manganese doping on remnant polarization and leakage current in (K0.44,Na0.52,Li0.04)(Nb0.84,Ta0.10,Sb0.06)O3 epitaxial thin films on SrTiO3 (2008)

Single phase, epitaxial, ⟨001⟩ oriented, undoped and 1mol% Mn-doped (K0.44,Na0.52,Li0.04)(Nb0.84,Ta0.10,Sb0.06)O3 thin films of 400nm thickness were synthesized on SrRuO3 coated SrTiO3. Such films exhibit well saturated hysteresis loops and have a spontaneous polarization (Ps) of 10μC∕cm2, which is a 150% higher over the Ps of the undoped composition. The coercive field of 1mol% Mn doped films is 13kV∕cm. Mn-doping results in three orders of magnitude decrease in leakage current above 50kV∕cm electric field, which we attribute to the suppression of intrinsic p-type conductivity of undoped films by Mn donors.
Bezafibrate increases very-long-chain acyl-CoA dehydrogenase protein and mRNA expression in deficient fibroblasts and is a potential therapy for fatty acid oxidation disorders (2005)

Inherited defect in very-long-chain acyl-CoA dehydrogenase (VLCAD), a mitochondrial enzyme catalyzing the initial step of long-chain fatty acid beta-oxidation (FAO), is one of the most frequent FAO enzyme defects. VLCAD deficiency is associated with clinical manifestations varying in severity, tissue involvement and age of onset. The molecular basis of VLCAD deficiency has been elucidated but therapeutic approaches are quite limited. In this study, we tested the hypothesis that fibrates, acting as agonist of peroxisome proliferator-activated receptors (PPARs), might stimulate FAO in VLCAD-deficient cells. We demonstrate that addition of bezafibrate or fenofibric acid in the culture medium induced a dose-dependent (up to 3-fold) increase in palmitate oxidation capacities in cells from patients with the myopathic form of VLCAD deficiency, but not in cells from severely affected patients. Complete normalization of cell FAO capacities could be achieved after exposure to 500 microm bezafibrate for 48 h. Cell therapy of VLCAD deficiency was related to drug-induced increases in VLCAD mRNA (+44 to +150%; P<0.001), protein (1.5-2-fold) and residual enzyme activity (up to 7.7-fold) in patient cells. Bezafibrate also diminished the production of toxic long-chain acylcarnitines by 90% in cells harboring moderate VLCAD deficiency. Finally, real-time PCR studies indicated that bezafibrate potentially stimulated gene expression of other enzymes in the beta-oxidation pathway. These data highlight the potential of fibrates in the correction of inborn FAO defects, as most mutations associated with these defects are compatible with the synthesis of a mutant protein with variable levels of residual enzyme activity.
Maximum Storage Capacity in Neural Networks (1987)

The upper storage capacity of a neural network for patterns of fixed magnetization m is calculated. The optimal capacity increases with the correlation m2 between the patterns.
Recent advances in contraceptive vaccine development: a mini-review (2005)

Contraceptive vaccines (CV) may provide viable and valuable alternatives to the presently available methods of contraception. The molecules that are being explored for CV development either target gamete production [luteinizing hormone-releasing hormone (LHRH)/GnRH, FSH], gamete function [sperm antigens and oocyte zona pellucida (ZP)], and gamete outcome (HCG). CV targeting gamete production have shown varied degrees of efficacy; however, they either affect sex steroids causing impotency and/or show only a partial rather than a complete effect in inhibiting gametogenesis. However, vaccines based on LHRH/GnRH are being developed by several pharmaceutical companies as substitutes for castration of domestic pets, farm and wild animals, and for therapeutic anticancer purposes such as in prostatic hypertrophy and carcinoma. These vaccines may also find applications in clinical situations that require the inhibition of increased secretions of sex steroids, such as in uterine fibroids, polycystic ovary syndrome, endometriosis and precocious puberty. CV targeting molecules involved in gamete function such as sperm antigens and ZP proteins are exciting choices. Sperm constitute the most promising and exciting target for CV. Several sperm-specific antigens have been delineated in several laboratories and are being actively explored for CV development. Studies are focused on delineating appropriate sperm-specific epitopes, and increasing the immunogenicity (specifically in the local genital tract) and efficacy on the vaccines. Anti-sperm antibody (ASA)-mediated immunoinfertility provides a naturally occurring model to indicate how a vaccine might work in humans. Vaccines based on ZP proteins are quite efficacious in producing contraceptive effects, but may induce oophoritis, affecting sex steroids. They are being successfully tested to control feral populations of dogs, deer, horses and elephants, and populations of several species of zoo animals. The current research for human applicability is focused on delineating infertility-related epitopes (B-cell epitopes) from oophoritis-inducing epitopes (T-cell epitopes). Vaccines targeting gamete outcome primarily focus on the HCG molecule. The HCG vaccine is the first vaccine to undergo Phase I and II clinical trials in humans. Both efficacy and lack of immunopathology have been reasonably well demonstrated for this vaccine. At the present time, studies are focused on increasing the immunogenicity and efficacy of the birth control vaccine, and examining its clinical applications in various HCG-producing cancers. The present article will focus on the current status of the anti-sperm, anti-ZP, anti-LHRH/GnRH and anti-HCG vaccines.
La enseñanza de la composición musical en Venezuela (antes, durante y después de Vicente Emilio Sojo) (2011)

La composicion musical en Venezuela ha tenido figuras importantes a lo largo de su historia, desde los tiempos de la Colonia hasta nuestros dias. El presente articulo tiene como objetivo realizar una reconstruccion historica de lo acontecido en esta area del quehacer musical academico, a traves de Vicente Emilio Sojo, un musico excepcional que dejo una huella imborrable en la educacion musical del pais, especialmente en el campo de la composicion. ABSTRACT The teaching of music composition in Venezuela (before, during and after Vicente Emilio Sojo) Musical composition in Venezuela has been represented by outstanding people throughout history since colonial times. This paper aims at reconstructing the history of main events in this area of academic work through an exceptional musician, Vicente Emilio Sojo, who left a lasting trace in music education, in general, and in the field of composition, in particular. RESUME L’enseignement de la composition musicale au Venezuela (avant, durant et apres Vicente Emilio Sojo) La composition musicale a ete representee au Venezuela par des gens remarquables a travers l’histoire, depuis la colonie jusqu’a nos jours. Cet article a pour but reconstruire l’histoire des principaux evenements dans ce domaine du travail academique a travers un musicien exceptionnel, Vicente Emilio Sojo, qui a laisse des traces ineffacables dans l’enseignement de la musique, en general, et dans la composition, en particulier. RESUMO Ensino da composicao musical na Venezuela (antes, durante e depois de Vicente Emilio Sojo) A composicao musical na Venezuela tem tido figuras importantes ao longo da sua historia, desde os tempos da Colonia ate os nossos dias. O presente articulo tem como objetivo fazer uma reconstrucao historica do acontecido nesta area do quefazer musical academico, atraves de Vicente Emilio Sojo, um musico excepcional que deixou um rastro inapagavel no ensino musical do pais, especialmente no campo da composicao.
Monoclonal antibodies specific for type 3 protein kinase C recognize distinct domains of protein kinase C and inhibit in vitro functional activity. (1988)

Monoclonal antibodies (mAbs) which distinguish Type 3 protein kinase C (PKC) from Types 1 and 2 have been obtained from mice immunized with purified Type 3 PKC from rabbit brain cytosol. Most of these mAbs (seven out of eight) selectively recognize Type 3 versus Types 1 and 2 PKC in both enzyme-linked immunosorbent and immunoblot assays. Trypsin treatment of Type 3 PKC reduced the immunoreactivity with 82-kDa PKC and generated immunoreactive fragments of 45 and 35 kDa. The mAbs can be divided into two classes based on their ability to recognize the 45-kDa catalytic fragment (5/8) or the 35 kDa regulatory domain fragment (3/8). Each of the mAbs inhibits phosphorylation of histone or lipocortin by PKC, although the extent of the inhibition varied. Only those mAbs that recognize the 35-kDa regulatory domain inhibited phorbol ester binding. The inhibition of both kinase and binding activities by this group of mAbs was sensitive to the concentration of phospholipid used in the assay. This functional inhibition suggests that these mAbs may be useful for defining the phospholipid binding domain(s) of Type 3 PKC. The mAbs recognized 82-kDa PKC in a variety of cell types; the presence of smaller molecular weight fragments was not consistently found. Distinct immunofluorescence staining patterns were observed with mAbs directed toward different epitopes, suggesting that there may be heterogeneity in the subcellular localization of PKC. The type specificity of these mAbs will make them valuable tools for studying activation and regulation of Type 3 PKC in cell culture model systems.
Magnetic current sensors for Space Station Freedom (1993)

Instrumentation on Space Station Freedom will require an accurate, isolated, and low-powered method of measuring high-DC currents. The magnetic current sensor presented here was created under the guidance of the NASA Lewis Research Center and is dependable, stable over time and temperature, and lightweight. Flexible topology allows the design of a pin-programmable hybrid package that contains analog and digital circuitry necessary for both bidirectional and unidirectional current sensing.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Global plasma demand in 2015 (2009)

Over the past fifty years, the plasma industry has gone through three phases, each one characterized by a different market driver: