gebhart/patrepeval huggingface dataset:
Text Mining and Social Network Analysis-based Patent Analysis Method for Improving Collaboration and Technology Transfer between University and Industry (2017)

Today, according to the increased importance of industry-university cooperation in the knowledge-based economy, support and the number of researches involved in industry- university cooperation has also steadily increased. But it is true that profits from the outcome of patents resulting from such cooperation, such as technology transfer and royalty fees, are lower than they are supposed to be, because of excessive patents applications, although some of them have little commercial potential. Therefore, this research aims to suggest a way to analyze and recognize patents, which enable efficient industry-university cooperation  and technology transfer. For the analysis, data on 1,061 patents was collected from 4 different universities. With the data, a quality-strategy matrix was arranged targeting the industry- university cooperation foundations’, US patents owned by universities, text mining, and social network analysis were carried out, particularly focusing on the patents in the advanced quality technology section of the matrix. Then core key words and IPC codes were obtained and key patents were analyzed by universities. As a result of the analysis, it was found that 4 key patents, 2 key IPC codes were drawn for University H, 4 key patents, 2 key IPC codes for University K, 6 key patents, 1 key IPC code for University Y, 14 key patents, and 2 key IPC codes for University S. This research is expected to have a great significance in contributing to the invigoration of industry-university cooperation based on the analysis result on patents and IPC codes, which enable efficient industry-university cooperation and technology transfer.
Applications of sequence space and SRG theories to distributed sample scrambling (1997)

In this paper, we consider how to apply the sequence space and the shift register generator (SRG) theories to distributed sample scrambling (DSS), which exhibits the best performance in scrambling of small frame-sized signals. We first consider how to predict scrambling sequences using their samples, which is a basic problem for a proper synchronization within the DSS systems. Then for DSS scramblers, we consider how to determine the scrambler SRGs and the sampling times for conveying information on the scrambling sequence; and for DSS descramblers, we consider how to determine the descrambler SRGs, the correction times, and the correction vectors for a proper synchronization. We further examine how to realize the scramblers and the descramblers with minimized circuit complexity. Finally, we demonstrate how to apply the results to DSS scramblers and descramblers for application in cell-based asynchronous transfer mode (ATM) transmission.
Measurement of velocity distribution inside the liquid bridge at oscillation sate by PIV method (1997)

info:eu-repo/semantics/published
Improving tactical plans with genetic algorithms (2002)

The problem of learning decision rules for sequential tasks is addressed, focusing on the problem of learning tactical plans from a simple flight simulator where a plane must avoid a missile. The learning method relies on the notion of competition and uses genetic algorithms to search the space of decision policies. In the research presented here, the use of available heuristic domain knowledge to initialize the population to produce better plans is investigated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
<i>P</i>-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function (2002)

Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and that these compounds play critical roles in the regulation of renal, pulmonary, and cardiac function and vascular tone. EETs are endothelium-derived vasodilators that hyperpolarize vascular smooth muscle (VSM) cells by activating K(+) channels. 20-HETE is a vasoconstrictor produced in VSM cells that reduces the open-state probability of Ca(2+)-activated K(+) channels. Inhibitors of the formation of 20-HETE block the myogenic response of renal, cerebral, and skeletal muscle arterioles in vitro and autoregulation of renal and cerebral blood flow in vivo. They also block tubuloglomerular feedback responses in vivo and the vasoconstrictor response to elevations in tissue PO(2) both in vivo and in vitro. The formation of 20-HETE in VSM is stimulated by angiotensin II and endothelin and is inhibited by nitric oxide (NO) and carbon monoxide (CO). Blockade of the formation of 20-HETE attenuates the vascular responses to angiotensin II, endothelin, norepinephrine, NO, and CO. In the kidney, EETs and 20-HETE are produced in the proximal tubule and the thick ascending loop of Henle. They regulate Na(+) transport in these nephron segments. 20-HETE also contributes to the mitogenic effects of a variety of growth factors in VSM, renal epithelial, and mesangial cells. The production of EETs and 20-HETE is altered in experimental and genetic models of hypertension, diabetes, uremia, toxemia of pregnancy, and hepatorenal syndrome. Given the importance of this pathway in the control of cardiovascular function, it is likely that CYP metabolites of arachidonic acid contribute to the changes in renal function and vascular tone associated with some of these conditions and that drugs that modify the formation and/or actions of EETs and 20-HETE may have therapeutic benefits.
The first regioregular head-to-tail poly(3-hexylthiophene-2,5-diyl) and a regiorandom isopolymer: nickel versus palladium catalysis of 2(5)-bromo-5(2)-(bromozincio)-3-hexylthiophene polymerization (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe first regioregular head-to-tail poly(3-hexylthiophene-2,5-diyl) and a regiorandom isopolymer: nickel versus palladium catalysis of 2(5)-bromo-5(2)-(bromozincio)-3-hexylthiophene polymerizationTian An Chen and Reuben D. RiekeCite this: J. Am. Chem. Soc. 1992, 114, 25, 10087–10088Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/ja00051a066https://doi.org/10.1021/ja00051a066research-articleACS PublicationsRequest reuse permissionsArticle Views3749Altmetric-Citations457LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Theoretical Studies of the Mechanics of the Fiber-Matrix Interface in Composites (1969)

This paper treats the development of pertinent theories that establish the properties of the fiber-matrix interface needed to achieve efficient composites and the development of a test technique to measure these properties. An equation is derived that relates the externally applied load to the failure mode, fiber tensile strength, and interface shear strength. This equation makes it possible to establish the interface strength that is required to obtain overall composite failure instead of interface failure. The effect of interface on the bending stiffness and Young's modulus of filamentary composites is investigated. A technique, based on shear-lag theory, that will measure the properties of the interface is presented. This technique involves pullout tests on fibers that are imbedded in a matrix. An approximate solution also is presented for the shear-stress distribution around a discontinuous fiber that is surrounded by six continuous fibers. The seven fibers are a part of a composite of infinite extent that is subjected to a remotely applied tensile stress. It is shown that there is a significant variation in the shear-stress distribution along the fiber length as well as around its circumference.
Phase III Randomized, Placebo-Controlled Trial of Docetaxel With or Without Gefitinib in Recurrent or Metastatic Head and Neck Cancer: An Eastern Cooperative Oncology Group Trial (2013)

The addition of gefitinib to docetaxel was well tolerated but did not improve outcomes in poor prognosis but otherwise unselected patients with SCCHN.
Circulating microRNAs are new and sensitive biomarkers of myocardial infarction (2010)

Acute MI up-regulated miR-1, -133a, -133b, and -499-5p plasma levels, both in humans and mice, whereas miR-122 and -375 were lower than control only in STEMI patients. These miRNAs represent novel biomarkers of cardiac damage.
Regulation and Regulatory Role of Proteinase Inhibitors (1995)

Excess or ill-timed proteolytic events have, of necessity, to be restrained. Therefore, there are partner proteinase inhibitors to most of the known mammalian enzymes that cleave peptide bonds, a situation that implicates the inhibitors in a myriad of normal as well as pathological processes. Here, what is currently known about the regulatory functions, the mode of action, and the control of gene expression of the commoner extracellularly acting proteinase inhibitors is reviewed. The review covers four families of serine proteinase inhibitors: the serpins, the Kunitz, Kazal, and leukoproteinase inhibitors, which overlap considerably in the range of their specificities but differ considerably in their respective structures and likely functions. There then follows a description of the growing family of metalloproteinase inhibitors (usually known by the acronym TIMP), the structurally varied cysteine proteinase inhibitors, and finally alpha 2-macroglobulin, a large multisubunit inhibitor, that is relatively catholic in its range of targets. The review concludes with two short sections, the first an overview of the acute phase response, which features several proteinase inhibitors from the different families discussed earlier, and the second, our prediction of where this research field is headed over the next decade.
Preparation of Core‐Sheath Nanofibers from Conducting Polymer Blends (2005)

Abstract Summary: Core‐sheath nanofibers with conductive polyaniline as the core and an insulating polymer as the sheath were prepared by electrospinning of blends of polyaniline with either polystyrene or polycarbonate. These unique core‐sheath structures offer potential in a number of applications including nanoelectronics. When polyaniline was blended with poly(methyl methacrylate) and poly(ethylene oxide), only isolated domains of polyaniline in beadlike structures were formed. The phase morphology of electrospun fibers is thought to be dependent on the high‐surface tension of the solution and the molecular weight of the polymers. Incompatibility of the polymers and low molecular weight of compositions played a key role in the formation of core‐sheath structures, as opposed to co‐continuous morphologies. TEM image of electrospun polyaniline/polystyrene nanofiber after staining by OsO 4 . The dark regions are polyaniline. magnified image TEM image of electrospun polyaniline/polystyrene nanofiber after staining by OsO 4 . The dark regions are polyaniline.
Geriatric gynecologic problems increasing. (1978)

Over a 3-year period, the percentage of geriatric patients with gynecologic problems treated in one Canadian hospital almost doubled. Pelvic pain, uterine bleeding, and voiding problems were the most common symptoms. Concomitant diseases existed in 60% of the patients, with cardiac and pulmonary problems the most frequent. Uterine fibroids and genital cancer were the most common pathologic diagnoses. Hysterectomy was part of the operative procedure in 37 of 50 patients, and these operations required more time and longer postoperative hospitalization than others. Complications developed in 24% of the patients, with cellulitis, phlebitis, and fever seen most often.
Long-lived respiratory immune response to filamentous hemagglutinin following Bordetella pertussis infection (1993)

Systemic and mucosal B-cell-mediated immune responses to purified filamentous hemagglutinin (FHA) in mice were analyzed at different times following a single respiratory infection with Bordetella pertussis. Serum immunoglobulin G (IgG) anti-FHA and respiratory IgG and IgA anti-FHA antibodies were first detected at 3 weeks postinfection, reached high levels by 8 weeks postinfection, and remained at high levels 12 to 32 weeks postinfection. FHA-specific B lymphocytes isolated from the spleens or lungs of uninfected control mice or mice convalescing from B. pertussis respiratory infection were analyzed in limiting-dilution cultures. Analysis of culture supernatants for the production of antibodies to FHA revealed an increased frequency of FHA-specific B cells of both the IgG- and the IgA-secreting classes in the lungs and tracheas of aerosol-challenged mice; these levels remained high as late as 25 weeks postinfection, compared with those in uninfected controls. No corresponding increase in the frequency of FHA-specific B cells in the spleens of aerosol-infected mice was observed. This long-lasting response observed in cultured cells was radiation resistant, a result suggesting that this response was due to B cells already activated in vivo. Polymerase chain reaction analysis revealed low but detectable levels of B. pertussis chromosomal DNA in 75% of mice tested at 8 weeks postinfection and 37.5% of mice tested at 26 weeks postinfection, at which times high levels of anti-FHA antibody were detected. One explanation for these data may be that, in this animal model, a major adhesin of B. pertussis can persist and interact with components of the immune system to stimulate the production of specific antibody in the respiratory tract many weeks after a single B. pertussis infection.
The Effect of Varying Molar Ratios of Potassium‐Magnesium Citrate on Thiazide‐Induced Hypokalemia and Magnesium Loss (1998)

This study was conducted to compare the value of an older formulation of potassium-magnesium citrate (K4MgCit2) with newer formulations (K3MgHCit2 and K5MgCit2Cl) with respect to the correction of thiazide-induced hypokalemia and magnesium loss, alkalinizing effect, and citraturic action. Sixty-two healthy volunteers first took hydrochlorothiazide 50 mg/day. After 3 weeks of thiazide treatment (or earlier if hypokalemia developed), they were randomized to take one of three drugs for 3 weeks while continuing thiazide: K4MgCit2 (49 mEq K, 25 mEq Mg, and 74 mEq citrate/day), K3MgHCit2 (49 mEq K, 33 mEq Mg, and 98 mEq citrate/day), and K5MgCit2Cl (49 mEq K, 20 mEq Mg, 10 mEq Cl and 59 mEq citrate/day). Outcome measures were changes in serum potassium and magnesium, and urinary potassium, magnesium, pH, and citrate. The three drugs were equally effective in correcting thiazide-induced hypokalemia. K3MgHCit2 and K4MgCit2 produced a small but significant increase in serum magnesium concentration, whereas K5MgCit2Cl did not. Although all three supplements significantly increased urinary pH and citrate, these effects were more marked with K3MgHCit2 and K4MgCit2 than with K5MgCit2. All three supplements were generally well tolerated, with the lowest side effect profile obtained with K4MgCit2. The new formulation of K3MgHCit2 exerts similar correction of thiazide-induced hypokalemia and magnesium loss, and enhancement of urinary pH and citrate, compared with the older K4MgCit2. However, it is less well tolerated. The new formulation of K5MgCit2Cl does not avert magnesium loss, and has less prominent alkalinizing and citraturic effects than the older preparation.
The Oropharyngeal Delivery of Interferons: Where Are We and Where Do We Need to Go? (1999)

The controversial concept of oral delivery of interferon (IFN) is reviewed in relation to possible mechanisms of action. Although there is a rational basis and some positive clinical results for believing that it may work, problems remain to understand which is the most effective IFN preparation and why. Owing to a minimal cost and lack of toxicity, the oral as well as other unconventional routes of IFN delivery deserve to be evaluated because they may become useful.
Combining competent crossover and mutation operators (2005)

This paper presents an approach to combine competent crossover and mutation operators via probabilistic model building. Both operators are based on the probabilistic model building procedure of the extended compact genetic algorithm (eCGA). The model sampling procedure of eCGA, which mimics the behavior of an idealized recombination---where the building blocks (BBs) are exchanged without disruption---is used as the competent crossover operator. On the other hand, a recently proposed BB-wise mutation operator---which uses the BB partition information to perform local search in the BB space---is used as the competent mutation operator. The resulting algorithm, called hybrid extended compact genetic algorithm (heCGA), makes use of the problem decomposition information for (1) effective recombination of BBs and (2) effective local search in the BB neighborhood. The proposed approach is tested on different problems that combine the core of three well known problem difficulty dimensions: deception, scaling, and noise. The results show that, in the absence of domain knowledge, the hybrid approach is more robust than either single-operator-based approach.
Analysis of antigen binding and idiotypic expression by antibodies with polyglycine-replaced complementarity-determining regions (1996)

We investigated the feasibility and usefulness, for structure-function studies, of removing the side chains of entire complementarity-determining regions (CDRs) of Abs by replacement with polyglycine. The CDRs of a murine Ab specific for p-azophenylarsonate (Ars) were replaced with polyglycine, one CDR at a time and in combinations, by oligonucleotide-directed mutagenesis of the V region genes. Mutant Abs were expressed in transfected hybridoma cells and analyzed for Ars binding and for idiotypic expression. The results suggest that, except for the longest CDRs, polyglycine replacement does not alter the general structure of the Ab molecule. However, for analysis of functional contributions of a CDR, the polyglycine replacement method appears to be most useful for CDRs with extended structures whose replacement by polyglycine does not affect the structure of other parts of the variable regions. In the current studies, such CDRs were CDR1 of the heavy chain (H1) and CDR2 of the light chain (L2). The polyglycine replacement of L2, which does not contain an Ag-contacting residue, allowed the formation of an Ars binding Ab. Furthermore, this mutant Ab revealed previously uncharacterized contributions of L2 to idiotypic expression. Polyglycine replacement of H1 abolished Ars binding as expected, because H1 contains an Ag-contacting residue. However, introduction of the contacting residue (Asn) on the polyglycine-replaced H1 background restored the ability of the Ab to bind Ars. The results suggest that polyglycine replacement of CDRs can provide structural information that complements and extends the information obtained by other methods.
Vriendschap wordt belangrijker (2010)

Het sociale leven van oudere volwassenen is gedurende de laatste twee decennia behoorlijk veranderd als gevolg van maatschappelijke ontwikkelingen. Onderliggende processen bij deze veranderingen zijn individualisering en het loslaten van tradities. Er is meer persoonlijke vrijheid in de keuze van leefstijl en identiteit, en grotere persoonlijke verantwoordelijkheid voor het ontwikkelen en in stand houden van een persoonlijk netwerk van sociale relaties
Structural Changes Accompanying Coke Calcination (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural Changes Accompanying Coke CalcinationMack P. Whittaker, Fred C. Miller, and Harlan C. FritzCite this: Ind. Eng. Chem. Prod. Res. Dev. 1970, 9, 2, 187–190Publication Date (Print):June 1, 1970Publication History Published online1 May 2002Published inissue 1 June 1970https://pubs.acs.org/doi/10.1021/i360034a014https://doi.org/10.1021/i360034a014research-articleACS PublicationsRequest reuse permissionsArticle Views128Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A Single Layer Higher Order Neural Net and its Application to Context Free Grammar Recognition (1990)

A single layer higher order dynamic topology neural net called HODYNE is described, targeted at natural language processing problems, HODYNE has an input layer of nodes containing concatenations of words from the input string, and grows nodes during training which are dependent on the training data. The training procedure also has some novel features. Results are presented on the problem of grammaticality determination. The results are encouraging, with almost perfect performance on unseen test sets derived from simple context-free grammars. An important aspect of this work is that the data sets used in training and testing are larger than is common in the research literature.
Characterization of the mouse SPARC/osteonectin gene. Intron/exon organization and an unusual promoter region. (1988)

Two overlapping cosmids have been isolated containing the entire murine gene for SPARC (osteonectin), a Ca2+-binding, phosphorylated glycoprotein associated with extracellular matrix synthesis and remodeling. The gene contains 10 exons and covers 26.5 kilobase pairs of DNA. Exon analysis shows that the two N-terminal glutamic acid-rich sequences which are predicted to undergo conformational change upon binding of calcium, as well as the C-terminal EF-hand Ca2+-binding domain are each encoded by a single exon. Comparative analysis of the exon sequence does not support the idea that the SPARC gene has evolved by shuffling of exons from other Ca2+-binding proteins. The 5' flanking region of the SPARC gene, which promotes transcription when placed in front of the bacterial chloramphenicol acetyltransferase gene, contains neither "TATA" nor "CAAT" box sequences. However, unlike most other genes lacking these motifs, mapping of the 5' end of the SPARC gene by RNase protection and primer extension analysis reveals only a single major and one minor transcription start site. The upstream region to -120 includes six repeats of the sequence GGAGG, two repeats of the sequence 5' GGAGG A/C GGAGGG 3', and a potential transcription factor AP-2 binding site.