gebhart/patrepeval huggingface dataset:
Cardiovascular effects of nebivolol in spontaneously hypertensive rats persist after treatment withdrawal (2005)

Objectives We observed previously that nebivolol treatment for 2 months reduced cardiovascular lesions in spontaneously hypertensive rats (SHR). Therefore, we investigated whether this beneficial effect is increased with a longer treatment, and its persistence after withdrawal. Methods Male SHR were treated with 8 mg/kg per day of nebivolol (N-SHR) for 6 months. A separate group was also given identical treatment but they were then monitored for a further 3 months after drug withdrawal. SHR and Wistar–Kyoto rats (WKY) receiving vehicle were used as controls. Systolic blood pressure and heart rate were measured using the tail-cuff method. Left ventricular weight/body weight ratio was calculated as the hypertrophy index. Cardiac and vascular fibrosis was evaluated on sections stained with sirious red. Vascular reactivity was evaluated on aortic rings through acetylcholine and sodium nitroprusside responses. The effect of treatment on vascular structure was assessed by lumen diameter, wall thickness and medial cross-sectional area determination. Results Blood pressure was reduced in N-SHR. After withdrawal it increased progressively, without reaching the values of the hypertensive controls. Cardiac hypertrophy and collagen content both in heart and aorta were significantly reduced, and these changes persisted after nebivolol suppression. Acetylcholine-induced relaxant response was improved by nebivolol and maintained after withdrawal. Medial thickness and cross-sectional area were significantly reduced in both conductance and resistance arteries, and these effects persisted after withdrawal. Conclusion The nebivolol antihypertensive effect was accompanied by an important reduction of hypertrophy and collagen deposition in both vascular and left ventricle tissue, which was maintained after a long period of therapy withdrawal.
Path selection using active measurement in multi-homed wireless networks (2004)

The mobile Internet is built upon a number of different wireless access networks with widely varying features in terms of coverage area, bandwidth, packet loss, and delay. To move across these different networks smoothly, issues associated with the changing features need to be addressed. In this paper, a path selection method for the coverage overlap area is proposed in which the mobile host actively measures the round trip time (RTT) and bottleneck bandwidth for each path and a path is selected based on four rules.
[Determination of the quality of fluorescent antibodies against human globulins using an antinuclear antibody standard]. (1978)

The authors present data concerning the standardization of the assessment of fluorescent antibodies against human globulins. Fluorescent emision proved to depend on the biochemical indices of the conjugates and on the quality of the initial raw material of crude serum. Materials of quantitative recording of the strength of fluorescence of the nuclear antigen treated with fluorescent antibodies are presented. A difference between the activity and the specific activity (with respect to normal human serum) of the preparations was noted.
III-V compound semiconductor nanostructures on silicon: epitaxial growth, properties, and applications in light emitting diodes and lasers (2009)

Significant developments have occurred in the area of III-V compound semiconductor nanostructures. The scope of developments includes quantum dots and nanowires epitaxially grown on Si substrates, as well as their applications in light emitting diodes and lasers. Such nanoscale heterostructures exhibit remarkable structural, electrical, and optical properties. The highly effective lateral stress relaxation, due to the presence of facet edges and free surfaces, enables the achievement of nearly defect-free III-V nanoscale heterostructures directly on Si, in spite of the large lattice mismatches and the surface incompatibility. With the incorporation of multiple quantum dot layers as highly effective three-dimensional dislocation filters, self-organized quantum dot lasers monolithically grown on Si exhibit, for the first time, relatively low threshold current (Jth = 900 A/cm2) and very high temperature stability (T0 = 244 K). III-V semiconductor nanowire light emitting diodes on Si, with emission wavelengths from UV to near-infrared, have also been demonstrated.
Les Poètes modernes et le cinéma (1910-1930) (2013)

Art machinique de l'image-mouvement, le cinéma intéresse des poètes novateurs comme Apollinaire et les surréalistes et constitue une mutation anthropologique qui pèse sur le devenir de la poésie. Cet ouvrage analyse les liens entre poètes et cinéma en étudiant des textes méconnus aux frontières entre les arts.
Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and -independent mechanisms (2008)

Regulation of mRNA stability by p38 MAPK has been linked to adenosine-uridine-rich elements (AURE) within the 3'-untranslated region (3'UTR) of mRNA. Using microarrays, we previously found that AURE-containing mRNA is over-represented among transcripts up-regulated by NO(*), an activator of p38 MAPK. Here, we investigated NO(*)-induced mRNA stabilization of specific AURE-containing genes to determine the sequence specificity and protein-binding interactions associated with this effect. IL-8, TNF-alpha, and p21/Waf1 3'UTRs were inserted into a luciferase (LUC) reporter gene system and found to decrease LUC activity and mRNA half-life in transfected THP-1 cells. The inhibitory effect of these 3'UTRs on LUC expression inversely correlated with the number of AUUUA motifs. Sequence truncation of the IL-8 3'UTR revealed that two segments, one with AURE sites and another without, contributed to mRNA destabilization. NO(*) activation of p38 MAPK increased LUC activity and mRNA half-life for reporter constructs that contained either of these IL-8 3'UTR segments. AURE-dependent and -independent NO(*) effects were blocked by p38 MAPK inhibition, and AURE-dependent effects were also blocked by site-directed mutagenesis of AUUUA sites. Two proteins, HuR and heterogeneous nuclear ribonucleoprotein A0, were identified, which bound to the AURE-containing region of exogenous and endogenous IL-8 mRNA in a NO(*)-p38 MAPK-dependent manner. These results demonstrate that NO(*)-p38 MAPK signaling can stabilize mRNA via AURE-dependent and -independent mechanisms.
Chaotic wavelength-hopping device for multiwavelength optical communications (2001)

We describe a laser device which generates wavelength-hopping sequences useful for optical communication. The wavelength-hopping sequences are generated using nonlinear dynamical behavior of a wavelength tunable laser with opto-electric feedback. Methods for data transmission using periodic and chaotic hopping sequences are described.
Lipoxin A4 Receptor Activation Is Distinct from That of the Formyl Peptide Receptor in Myeloid Cells: Inhibition of CD11/18 Expression by Lipoxin A4-Lipoxin A4 Receptor Interaction (1995)

Lipoxin A4 (LXA4) interacts with high-affinity receptors in human neutrophils and differentiated HL-60 cells. Recently, we characterized a myeloid-derived cDNA that encodes a LXA4 high-affinity receptor (LXA4R) [Fiore, S., Maddox, J. F., Perez, H. D., and Serhan, C. N. (1994) J. Exp. Med. 180, 253-260] denoted earlier as a related N-formyl peptide receptor (RFP). To examine the selectivity of this receptor we tested its preference for specific binding of 3H-LXA4 versus 3H-N-formylmethionyl-leucyl-phenylalanine (3H-FMLP). When receptor-transfected Chinese hamster ovary cells were exposed to either 3H-LXA4 or 3H-FMLP, the receptor affinity for LXA4 exceeded by 1000-fold that of FMLP (6.1 nM vs 5 microM). Upon differentiation, HL-60 cells acquire high-affinity binding sites and respond to both LXA4 and FMLP. Northern blot analysis of differentiated HL-60 cells using an RFP probe showed a characteristic band at 2.1 kb. Differentiated HL-60 cells exposed to an RFP antisense oligonucleotide selectively lost 3H-LXA4 binding as well as LXA4-stimulated lipid remodeling that paralleled the loss of mRNA for LXA4R. In contrast, the specific mRNA for the FMLP receptor, 3H-FMLP specific binding, and FMLP-induced phospholipase D activity were still observed. Treatment of human neutrophils with antisera raised against a peptide in the LXA4R third extracellular domain also resulted in selective abrogation of 3H-LXA4 specific binding with polymorphonuclear leukocytes (PMN) without blocking 3H-FMLP binding. FMLP-stimulated CD11b upregulation as well as homotypic aggregation of PMN was inhibited by LXA4 (which at 10(-9) M gave approximately 1 log unit shift to the right in the FMLP dose-response curve). The addition of LXA4R antisera did not alter FMLP-induced responses in PMN but completely blocked LXA4 actions. These results indicate that altering the expression of the LXA4R protein by blockage of transcriptional mechanisms or hindrance of the LXA4R extracellular domains leads to loss of LXA4 specific binding and blockage of LXA4 signaling. Moreover, they indicate that in myeloid cells LXA4-LXA4R interactions are dissociable from those of FMLP and that LXA4 regulates CD11/18 on the PMN surface.
EcI5, a group IIB intron with high retrohoming frequency: DNA target site recognition and use in gene targeting (2009)

We find that group II intron EcI5, a subclass CL/IIB1 intron from an Escherichia coli virulence plasmid, is highly active in retrohoming in E. coli. Both full-length EcI5 and an EcI5-DeltaORF intron with the intron-encoded protein expressed separately from the same donor plasmid retrohome into a recipient plasmid target site at substantially higher frequencies than do similarly configured Lactococcus lactis Ll.LtrB introns. A comprehensive view of DNA target site recognition by EcI5 was obtained from selection experiments with donor and recipient plasmid libraries in which different recognition elements were randomized. These experiments suggest that EcI5, like other mobile group II introns, recognizes DNA target sequences by using both the intron-encoded protein and base-pairing of the intron RNA, with the latter involving EBS1, EBS2, and EBS3 sequences characteristic of class IIB introns. The intron-encoded protein appears to recognize a small number of bases flanking those recognized by the intron RNA, but their identity is different than in previously characterized group II introns. A computer algorithm based on the empirically determined DNA recognition rules enabled retargeting of EcI5 to integrate specifically at 10 different sites in the chromosomal lacZ gene at frequencies up to 98% without selection. Our findings provide insight into modes of DNA target site recognition used by mobile group II introns. More generally, they show how the diversity of mobile group II introns can be exploited to provide a large variety of different target specificities and potentially other useful properties for gene targeting.
Analysis of clinicopthologic features and prognosis of 4 cases primary gastric anaplastic large cell lymphomas (2012)

Objective To evaluate clinicopathologic features and prognosis of primary gastric anaplastic large cell lymphomas (ALCL).Methods Clinical data and parafiin blocks of 4 patients diagnosed with primary gastric ALCL were obtained. The diagnosis of all cases was based on the criteria of WHO classification of hematolymphoid neoplasm.Furthermore,chromosomal rearrangement involving ALK gene was detected by interphase fluorescence in situ hybridization (FISH) and Epstein-Barr virus (EBV) status was determined by in situ hybridization(ISH) for EBV-encoded small RNAs (EBERs).Results The patients (3 males and 1 female) were from 27 to 87 years old, with a median age of 58.5 years. All the four cases presented with a solitary ulcerative mass in stomach. Morphologically, the normal architecture of gastric wall was effaced by the diffuse infiltration of tumor cells in which the characteristic hallmark cells were easily identified.The tumor cells of all cases showed a consistently strong expression of LCA and CD30,and CD3e was expressed in 3 of the 4 cases.Both ALK expression and ALK gene rearrangements were negative in all cases.Two cases underwent total or partial gastrectomy followed by CHOP chemotherapy. Another one patient was treated with chemotherapy and autologous stem cell transplantation. None of these 3 patients developed a relapse or progression till the last follow-up on Nov 30,2011. While the rest one patient refused to take any treatment and died 20 months after diagnosis. Conclusions Primary gastric ALCL is very rare and usually ALK negative. Its pathologic features as well as the clinical outcome are quite similar to the ALK negative ALCL from other sites, except the more frequently positive CD3e Early diagnosis and proper therapy are of great significance to the prognosis.

Key words: 
Lymphomas, large-cell, anaplastic;  Stomach;  Primary
‘‘Tray’’ type calorimeter for the 15–300 K temperature range: Copper as a specific heat standard in this range (1987)

A calorimeter is described in which thermal contact with the sample is made via a grease film. Radiation shields built into the calorimeter minimize the effect of temperature gradients. Used in an adiabatic shield system the apparatus gives results of high precision and accuracy. The new design permits easy sample changing but there is a small specific heat anomaly owing to melting of the grease film. An all-metal water triple point cell can be installed in place of the sample to check the temperature measuring equipment. The adiabatic shield system used had four independently controlled elements. Experiment showed that a single controlled element is sufficient for discontinuous heating calorimetry. The apparatus could be run in both continuous and discontinuous heating modes. There was no significant difference in results. Measurements on pure copper are reported and the use of this material as a specific heat standard up to 300 K is discussed.
Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina (2017)

Herein we showcase the potential of ultrasound-responsive nanobubbles in enhancing macromolecular permeation through layers of the retina, ultimately leading to significant and direct intracellular delivery; this being effectively demonstrated across three relevant and distinct retinal cell lines. Stably engineered nanobubbles of a highly homogenous and echogenic nature were fully characterised using dynamic light scattering, B-scan ultrasound and transmission electron microscopy (TEM). The nanobubbles appeared as spherical liposome-like structures under TEM, accompanied by an opaque luminal core and darkened corona around their periphery, with both features indicative of efficient gas entrapment and adsorption, respectively. A nanobubble +/- ultrasound sweeping study was conducted next, which determined the maximum tolerated dose for each cell line. Detection of underlying cellular stress was verified using the biomarker heat shock protein 70, measured before and after treatment with optimised ultrasound. Next, with safety to nanobubbles and optimised ultrasound demonstrated, each human or mouse-derived cell population was incubated with biotinylated rabbit-IgG in the presence and absence of ultrasound +/- nanobubbles. Intracellular delivery of antibody in each cell type was then quantified using Cy3-streptavidin. Nanobubbles and optimised ultrasound were found to be negligibly toxic across all cell lines tested. Macromolecular internalisation was achieved to significant, yet varying degrees in all three cell lines. The results of this study pave the way towards better understanding mechanisms underlying cellular responsiveness to ultrasound-triggered drug delivery in future ex vivo and in vivo models of the posterior eye.
Using sonar in terrain-aided underwater navigation (2002)

In many ways autonomous navigation of underwater vehicles is a 'holy grail' of subsea robotics. For an AUV to continually estimate its pose (position and orientation) and operate within an initially unknown environment a solution is required to the simultaneous map building and localisation or 'SLAM' problem. The paper describes and investigates an inertial and terrain based approach to this problem. The fusion of body frame inertial and sonar based world frame feature information can form part of a robust navigation algorithm suitable for implementation in both artificial and natural environments. Particular attention is given to the role of the sonar and its ability to detect and track terrain features.
Computational Study on Prediction of Bioactivity for Regulation of New Designer Drugs (2012)

A method of prediction of biological activities of chemicals has been developed as a new drug-discovery technology. In recent years, a wide distribution of non-controlled psychotropic substances has become a serious problem in Japan. It takes a long time to evaluate their bioactivity in vitro and in vivo. Computer simulation could regulate new designer drugs in a short time. Prediction of biological activities of these drugs was performed by quantitative structure-activity relationship (QSAR) and pharmacophore-fingerprint method. A preliminary demonstration to predict the bioactivity of 4-methcathinone, a cathinone derivative that is widely distributed, by two methods is described herein.
What Brings Intentions to Mind? An In Situ Study of Prospective Memory (1997)

In a naturalistic study, we aimed to uncover the relationship between thinking about and remembering intentions. Electronic badges allowed us to track the activities of subjects within their work environment. Over two weeks, subjects were asked to respond using a button on their badges (1) every two hours (Time task); (2) whenever they were in a particular room (Place task). In addition, whenever they thought about the task, they were asked to indicate this with their badges. Although subjects thought about the Time task more, they forgot to respond more often than in the Place task. In the Time task, there was a marked absence of thoughts about the task following successful remembering. When subjects remembered the Place task, thoughts increased with proximity to the target location. In both tasks, thoughts about intentions occurred more in places such as stairwells than in locations where people tended to settle. On the basis of these findings, possible mechanisms for prospective memory are discussed.
Sodium Hexametaphosphate as an Aid in the Treatment of Periodontal Disease (1944)

Peer Reviewed
Prompt Gamma Neutron Activation Analysis (1995)

Instruments and shielding neutron damage and induced effects on nuclear instruments used for PGAA prompt gamma neutron activation analysis with reactor neutron in situ applications. (Part contents).
Comprehensive gearbox design using expert system techniques (2008)

Abstract In this study, a computer aided design (CAD) software is developed in order to design various gearboxes under several conditions, to draw detailed assembly drawings and to carry out comprehensive gearbox analysis. An expert system computer language, VisualLISP, is used for this purpose. With the developed software, gear designs and shaft analysis can be carried out by using necessary parameters for the gear box. Certain detailed analyses such as rolling bearing selection and gearbox volume determination are realized by the expert system techniques. © 2008 Wiley Periodicals, Inc. Comput Appl Eng Educ 16: 157–164, 2008; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae.20132
Topical perfluorodecalin resolves immediate whitening reactions and allows rapid effective multiple pass treatment of tattoos (2012)

Multiple-pass tattoo removal using PFD to deliver rapid sequential passes (R0 method) appears equally effective as the R20 method, in a total treatment time averaging 5 minutes, and more effective than single pass treatment. OCT-visualized whitening-associated "bubbles," upon treatment with PFD, resolve twice as rapidly as spontaneous resolution.
Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration (2016)

α-SYN plays a central role in the pathophysiology of PD through initiation of neuroinflammatory responses. Using an α-SYN overexpression PD model, we demonstrate a beneficial therapeutic effect of AZD1480, a specific inhibitor of JAK1/2, in suppressing neuroinflammation and neurodegeneration. Our findings document that inhibition of the JAK/STAT pathway influences both innate and adaptive immune responses by suppressing α-SYN-induced microglia and macrophage activation and CD4(+) T-cell recruitment into the CNS, ultimately suppressing neurodegeneration. These findings are the first documentation that suppression of the JAK/STAT pathway disrupts the circuitry of neuroinflammation and neurodegeneration, thus attenuating PD pathogenesis. JAK inhibitors may be a viable therapeutic option for the treatment of PD patients.
Boron clusters in medicinal chemistry: perspectives and problems (2015)

Abstract Boron clusters have been employed successfully as constituents in bioactive substances. In this review, the perspectives of boron clusters for drug design and problems to be solved for a broader application are discussed, and a list of actions is given for overcoming the problems.
Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration (2009)

Little is known about which components of the axonal cytoskeleton might break during rapid mechanical deformation, such as occurs in traumatic brain injury. Here, we micropatterned neuronal cell cultures on silicone membranes to induce dynamic stretch exclusively of axon fascicles. After stretch, undulating distortions formed along the axons that gradually relaxed back to a straight orientation, demonstrating a delayed elastic response. Subsequently, swellings developed, leading to degeneration of almost all axons by 24 h. Stabilizing the microtubules with taxol maintained the undulating geometry after injury but greatly reduced axon degeneration. Conversely, destabilizing microtubules with nocodazole prevented undulations but greatly increased the rate of axon loss. Ultrastructural analyses of axons postinjury revealed immediate breakage and buckling of microtubules in axon undulations and progressive loss of microtubules. Collectively, these data suggest that dynamic stretch of axons induces direct mechanical failure at specific points along microtubules. This microtubule disorganization impedes normal relaxation of the axons, resulting in undulations. However, this physical damage also triggers progressive disassembly of the microtubules around the breakage points. While the disintegration of microtubules allows delayed recovery of the "normal" straight axon morphology, it comes at a great cost by interrupting axonal transport, leading to axonal swelling and degeneration.