gebhart/patrepeval huggingface dataset:
Cyclosporin A inhibits the delayed‐type hypersensitivity reaction: impaired production of early pro‐inflammatory mediator(s) (1984)

The effect of cyclosporin A (CsA) on the delayed-type hypersensitivity (DTH) elicited in mice by sheep red blood cells was investigated. Evidence is presented that a single injection of CsA adversely affects the inflammatory reaction. Sensitized T lymphocytes initiate the DTH reaction by their recruiting activity on phagocytic cells which infiltrate the cutaneous site of antigen deposition. CsA administration has no adverse effect on the recruitment of phagocytic cells at the site of the inflammatory reaction. The present studies show that CsA acts on specific T cells: (a) in adoptive transfer, T-DTH-mediating cells cannot elicit a response in mice treated with CsA 8 h before; (b) when collected 8 h after a single injection of CsA, T-DTH-mediating lymphocytes are no longer able to adoptively transfer the reaction. This conclusion is strengthened by in vitro studies: (a) the frequency of T-DTH-mediating lymphocytes is 50-fold decreased after a short in vitro incubation with CsA; (b) in vitro production by concanavalin A-activated lymphocytes of chemotactic pro-inflammatory mediator(s) is abolished in presence of CsA.
Glucose repression in the yeast <i>Saccharomyces cerevisiae</i> (1992)

Understanding the mechanism of glucose repression in yeast has proved to be a difficult and challenging problem. A multitude of genes in different pathways are repressed by glucose at the level of transcription. The SUC2 gene, which encodes invertase, is an excellent reporter gene for glucose repression, since its expression is controlled exclusively by this pathway. Genetic analysis has identified numerous regulatory mutations which can either prevent derepression of SUC2 or render its expression insensitive to glucose repression. These mutations allow us to sketch the outlines of a pathway for general glucose repression, which has several key elements: hexokinase PII, encoded by HXK2, which seems to play a role in the sensing of glucose levels; the protein kinase encoded by SNF1, whose activity is required for derepression of many glucose-repressible genes; and the MIG1 repressor protein, which binds to the upstream regions of SUC2 and other glucose-repressible genes. Repression by MIG1 requires the activity of the CYC8 and TUP1 proteins. Glucose repression of other sets of genes seems to be controlled by the general glucose repression pathway acting in concert with other mechanisms. In the cases of the GAL genes and possibly CYC1, regulation is mediated by a cascade in which the general pathway represses expression of a positive transcriptional activator.
Climatic change and its affect on world food (1975)

In February 1972, earth-orbiting artificial satellites revealed the existence of a greatly increased area of the snow and ice cover of the north polar cap as compared to all previous years of space-age observations. Some scientists believe that this may have presaged the onset of the dramatic climate anomalies of 1972 that brought far-reaching adversities to the world's peoples. Moreover, there is mounting evidence that the bad climate of 1972 may be the forerunner of a long series of less favourable agricultural crop years that lie ahead for most world societies. Thus widespread food shortages threaten at a time when world population is increasing rapidly. Indeed, less favourable climate may be the new global norm. The Earth may have entered a new ‘little ice age’. Perhaps this future period will not be so extreme as it was at the beginning of the 18th Century, but it seen likely, at least, to be a cooler period resembling the hemispheric climatic regimes of the period from 1880–1920.
Antenatal maternal stress and long‐term effects on child neurodevelopment: how and why? (2007)

We review a significant body of evidence from independent prospective studies that if a mother is stressed while pregnant, her child is substantially more likely to have emotional or cognitive problems, including an increased risk of attentional deficit/hyperactivity, anxiety, and language delay. These findings are independent of effects due to maternal postnatal depression and anxiety. We still do not know what forms of anxiety or stress are most detrimental, but research suggests that the relationship with the partner can be important in this respect. The magnitude of these effects is clinically significant, as the attributable load of emotional/behavioral problems due to antenatal stress and/or anxiety is approximately 15%. Animal models suggest that activity of the stress‐responsive hypothalamic‐pituitary‐adrenal (HPA) axis and its hormonal end‐product cortisol are involved in these effects in both mother and offspring. The fetal environment can be altered if stress in the mother changes her hormonal profile, and in humans, there is a strong correlation between maternal and fetal cortisol levels. However, many problems remain in understanding the mechanisms involved in this interaction. For example, maternal cortisol responses to stress decline over the course of pregnancy, and earlier in pregnancy, the link between maternal and fetal cortisol is less robust. It is possible that the effects of maternal anxiety and stress on the developing fetus and child are moderated by other factors such as a maternal diet (e.g., protein load). It is suggested that extra vigilance or anxiety, readily distracted attention, or a hyper‐responsive HPA axis may have been adaptive in a stressful environment during evolution, but exists today at the cost of vulnerability to neurodevelopmental disorders.
Progressive Loss of Retinal Ganglion Cell Function Is Hindered with IOP-Lowering Treatment in Early Glaucoma (2012)

Progressive loss of RGC function in early glaucoma may be alleviated after IOP lowering, as measured by PERG.
The immune checkpoint regulator PD-L1 is a specific target for naturally occurring CD4<sup>+</sup>T cells (2013)

Programmed cell death 1 ligand 1 (PD-L1) is an important regulator of T-cell responses and may consequently limit anticancer immunity. We have recently identified PD-L1-specific, cytotoxic CD8<sup>+</sup> T cells. In the present study, we develop these findings and report that CD4<sup>+</sup> helper T cells spontaneously recognize PD-L1. We examined the locality of a previously identified HLA-A*0201-restricted PD-L1-epitope for the presence of possible CD4<sup>+</sup> T-cell epitopes. Thus, we identified naturally occurring PD-L1-specific CD4<sup>+</sup> T cells among the peripheral blood lymphocytes of cancer patients and - to lesser extents - healthy donors, by means of ELISPOT assays. PD-L1-specific CD4<sup>+</sup> T cells appeared to be T<sub>H</sub>17 cells exhibiting an effector T-cell cytokine profile. Hence, PD-L1-specific CD4<sup>+</sup> T cells released interferon γ (IFNγ), tumor necrosis factor α (TNFα) and interleukin-17 (IL-17) in response to a long PD-L1-derived peptide. Furthermore, we demonstrate that the specific recognition of PD-L1 by CD4<sup>+</sup> T cells is MHC class II-restricted. Natural T-cell responses against PD-L1 are noteworthy as they may play a prominent role in the regulation of the immune system. Thus, cytokine release from PD-L1-specific CD4<sup>+</sup> T cells may surmount the overall immunosuppressive actions of this immune checkpoint regulator. Moreover, PD-L1-specific T cells might be useful for anticancer immunotherapy, as they may counteract common mechanisms of immune escape mediated by the PD-L1/PD-1 pathway.
Multi-Way, Multilingual Neural Machine Translation with a Shared Attention Mechanism (2016)

We propose multi-way, multilingual neural machine translation. The proposed approach enables a single neural translation model to translate between multiple languages, with a number of parameters that grows only linearly with the number of languages. This is made possible by having a single attention mechanism that is shared across all language pairs. We train the proposed multiway, multilingual model on ten language pairs from WMT'15 simultaneously and observe clear performance improvements over models trained on only one language pair. In particular, we observe that the proposed model significantly improves the translation quality of low-resource language pairs.
Do Deep Convolutional Nets Really Need to be Deep and Convolutional? (2016)

Yes, they do. This paper provides the first empirical demonstration that deep convolutional models really need to be both deep and convolutional, even when trained with methods such as distillation that allow small or shallow models of high accuracy to be trained. Although previous research showed that shallow feed-forward nets sometimes can learn the complex functions previously learned by deep nets while using the same number of parameters as the deep models they mimic, in this paper we demonstrate that the same methods cannot be used to train accurate models on CIFAR-10 unless the student models contain multiple layers of convolution. Although the student models do not have to be as deep as the teacher model they mimic, the students need multiple convolutional layers to learn functions of comparable accuracy as the deep convolutional teacher.
Role of C‐terminal cytoplasmic domain of the AT2 receptor in ligand binding and signaling (2002)

A stop codon at position 322 was introduced to generate a truncated, C-terminal-deleted AT2 receptor. Expression studies in Xenopus oocytes showed that C-terminal-deleted AT2 had reduced affinity to [(125)I]angiotensin II (K(d)=1.7 nM) and enhanced binding of the AT2-specific peptidic ligand [(125)I]CGP42112A (K(d)=0.097 nM). AT2 activation by angiotensin II resulted in reduction of cGMP levels in oocytes and this reduction was further enhanced by C-terminal deletion, implying that the C-terminus may have a negative effect on the AT2-mediated cGMP reduction. Moreover, interaction of the AT2 with the ATP-binding domain of the human ErbB3 receptor in yeast two-hybrid assay was abolished by C-terminal deletion. In summary, the C-terminal cytoplasmic tail of AT2 modulates its ligand binding and signaling properties.
Double patterning technology friendly detailed routing (2008)

Double patterning technology (DPT) is a most likely lithography solution for 32/22 nm technology nodes as of 2008 due to the delay of extreme ultra violet lithography. However, it should hurdle two challenges before being introduced to mass production, layout decomposition and overlay error. In this paper, we present the first detailed routing algorithm for DPT to improve layout decomposability and robustness against overlay error, by minimizing indecomposable wirelength and the number of stitches. Experimental results show that the proposed approach improves the quality of layout significantly in terms of decomposability and the number of stitches with 3.6x speedup, compared with a current industrial DPT design flow.
Structure elucidation of the janthitrems, novel tremorgenic mycotoxins from Penicillium janthinellum (1984)

The assignment of the structures (1)–(3) to janthitrems E-G, tremorgenic mycotoxins isolated from cultures of Penicillium janthinellum is based on a detailed study of their highfield 1H and 13C n.m.r. spectra. In the structure elucidation extensive use was made of heteronuclear 13C-{1H} selective population inversion (SPI) and homonuclear 1H-{1H} n.O.e. experiments.
Impossibility of large phase shifts via the giant Kerr effect with single-photon wave packets (2010)

An approximate analytical solution is presented, along with numerical calculations, for a system of two single-photon wave packets interacting via an ideal, localized Kerr medium. It is shown that, because of spontaneous emission into the initially unoccupied temporal modes, the cross-phase-modulation in the Schr\"odinger picture is very small as long as the spectral width of the single-photon pulses is well within the medium's bandwidth. In this limit, the Hamiltonian used can be derived from the ``giant Kerr effect'' for a four-level atom, under conditions of electromagnetically induced transparency; it is shown explicitly that the linear absorption in this system increases as the pulse's spectral width approaches the medium's transparency bandwidth, and hence, as long as the absorption probability remains small, the maximum cross-phase-modulation is limited to essentially useless values. These results are in agreement with the general, causality-based, and unitarity-based arguments of Shapiro and Razavi [J. H. Shapiro, Phys. Rev. A 73, 062305 (2006); J. H. Shapiro and M. Razavi, New J. Phys. 9, 16 (2007)].
Exploring place through user-generated content: Using Flickr to describe city cores (2010)

Terms used to describe city centers, such as Downtown, are key concepts in everyday or vernacular language. Here, we explore such language by harvesting georeferenced and tagged metadata associated with 8 million Flickr images and thus consider how large numbers of people name city core areas. The nature of errors and imprecision in tagging and georeferencing are quantified, and automatically generated precision measures appear to mirror errors in the positioning of images. Users seek to ascribe appropriate semantics to images, though bulk-uploading and bulk-tagging may introduce bias. Between 0.5-2% of tags associated with georeferenced images analyzed describe city core areas generically, while 70% of all georeferenced images analyzed include specific place name tags, with place names at the granularity of city names being by far the most common. Using Flickr metadata, it is possible not only to describe the use of the term Downtown across the USA, but also to explore the borders of city center neighborhoods at the level of individual cities, whilst accounting for bias by the use of tag profiles.
Function and evolution of sex determination mechanisms, genes and pathways in insects (2010)

Animals have evolved a bewildering diversity of mechanisms to determine the two sexes. Studies of sex determination genes--their history and function--in non-model insects and Drosophila have allowed us to begin to understand the generation of sex determination diversity. One common theme from these studies is that evolved mechanisms produce activities in either males or females to control a shared gene switch that regulates sexual development. Only a few small-scale changes in existing and duplicated genes are sufficient to generate large differences in sex determination systems. This review summarises recent findings in insects, surveys evidence of how and why sex determination mechanisms can change rapidly and suggests fruitful areas of future research.
Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells (2003)

Lactoferrin (Lf), a multifunctional molecule present in mammalian secretions and blood, plays important roles in host defense and cancer. Indeed, Lf has been reported to inhibit the proliferation of cancerous mammary gland epithelial cells and manifest a potent antiviral activity against human immunodeficiency virus and human cytomegalovirus. The Lf-binding sites on the cell surface appear to be proteoglycans and other as yet undefined protein(s). Here, we isolated a Lf-binding 105 kDa molecular mass protein from cell extracts and identified it as human nucleolin. Medium-affinity interactions ( approximately 240 nm) between Lf and purified nucleolin were further illustrated by surface plasmon resonance assays. The interaction of Lf with the cell surface-expressed nucleolin was then demonstrated through competitive binding studies between Lf and the anti-human immunodeficiency virus pseudopeptide, HB-19, which binds specifically surface-expressed nucleolin independently of proteoglycans. Interestingly, binding competition studies between HB-19 and various Lf derivatives in proteoglycan-deficient hamster cells suggested that the nucleolin-binding site is located in both the N- and C-terminal lobes of Lf, whereas the basic N-terminal region is dispensable. On intact cells, Lf co-localizes with surface nucleolin and together they become internalized through vesicles of the recycling/degradation pathway by an active process. Morever, a small proportion of Lf appears to translocate in the nucleus of cells. Finally, the observations that endocytosis of Lf is inhibited by the HB-19 pseudopeptide, and the lack of Lf endocytosis in proteoglycan-deficient cells despite Lf binding, point out that both nucleolin and proteoglycans are implicated in the mechanism of Lf endocytosis.
Particle swarm optimization for demand side management in smart grid (2015)

Demand side management is a useful and necessary tool in smart grid energy management system to reduce total power demand during peak demand periods and hence, enhancing grid sustainability and reducing overall cost. This paper discusses a new load shifting approach for demand side management in smart grid energy management. This approach optimizes the consumption curves of household, commercial and industrial consumers. The proposed algorithm in this approach minimizes the cost incurred by users while taking into account users' individual preferences for the loads by setting priorities and preferred time intervals for load scheduling.
Comparative Study of Uniform Versus Supersteep Retrograde MOSFET Channel Doping and Implications for 6-T SRAM Yield (2013)

The benefit of supersteep retrograde (SSR) channel doping for suppressing short-channel effects in planar bulk MOSFET performance is studied via technology computer-aided design simulation of devices with gate length L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> = 28 nm. It is found that drain-induced barrier lowering is reduced by more than 40%, and variation in saturation threshold voltage (σ V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T,Sat</sub> ), caused by random dopant fluctuation, is reduced by ~50%, with SSR channel doping. However, degraded drive current is observed for SSR channel doping due to enhanced body effect. Estimations of six-transistor static random access memory (SRAM) cell yield indicate that 33% reduction in the minimum operating voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MIN,SRAM</sub> ) can be achieved with SSR channel doping.
Chemistry and Applications of Photocatalytic Oxidation of Thin Organic Films (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry and Applications of Photocatalytic Oxidation of Thin Organic FilmsAdam HellerCite this: Acc. Chem. Res. 1995, 28, 12, 503–508Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/ar00060a006https://doi.org/10.1021/ar00060a006research-articleACS PublicationsRequest reuse permissionsArticle Views2189Altmetric-Citations410LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Field emission from vertically aligned few-layer graphene (2008)

The electric field emission behavior of vertically aligned few-layer graphene was studied in a parallel plate–type setup. Few-layer graphene was synthesized in the absence of any metallic catalyst by microwave plasma enhanced chemical vapor deposition with gas mixtures of methane and hydrogen. The deposit consists of nanostructures that are several micrometers wide, highly crystalline stacks of four to six atomic layers of graphene, aligned vertically to the substrate surface in a high density network. The few-layer graphene is found to be a good field emitter, characterized by turn-on fields as low as 1 V/μm and field amplification factors up to several thousands. We observe a clear dependence of the few-layer graphene field emission behavior on the synthesis parameters: Hydrogen is identified as an efficient etchant to improve field emission, and samples grown on titanium show lower turn-on field values and higher amplification factors when compared to samples grown on silicon.
Rac1 and Rac3 are targets for geranylgeranyltransferase I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling. (2003)

Rac1, a Rho family GTPase, is a mediator of diverse cellular functions including membrane ruffling, cell cycle progression, and transformation. Rac3, a close relative of Rac1, is less well characterized. Posttranslational addition of geranylgeranyl isoprenoid lipids to Rac proteins is required for biological activity. Inhibitors of geranylgeranyl transferase I (GGTIs) are currently under investigation as a possible anticancer therapy, although the targets of GGTIs have not been determined. We created COOH-terminal mutants of Rac1 and Rac3 that are farnesylated and used them to characterize Rac1 and Rac3 as physiological targets of GGTIs. We show that, like Rac1, activated Rac3 causes transformation and leads to membrane ruffling. Farnesylated versions of Rac1 and Rac3 retain the ability to signal to the transcription factor c-Jun and cause membrane ruffling and transformation, indicating that switching isoprenoid modification does not alter function. Finally, treatment with GGTIs led to the inhibition of membrane-ruffling and transforming activities of both activated and wild-type Rac1 and Rac3. However, the farnesylated versions of both activated and wild-type Rac1 and Rac3 were resistant to the inhibitory effects of GGTIs. These results illustrate that Rac1 and Rac3 are potential physiological targets for these novel drugs.
Pretreatment with intraventricular aurintricarboxylic acid decreases infarct size by inhibiting apoptosis following transient global ischemia in gerbils (1998)

The goal of this study was to determine whether aurintricarboxylic acid (ATA), an endonuclease inhibitor known to inhibit apoptosis, could ameliorate cell damage in a gerbil model of transient ischemia. Transient ischemia was induced in gerbils by bilateral carotid artery occlusion for a period of 5 minutes. Four micrograms of ATA was administered intraventricularly 1 hour before ischemia, and the brains were assessed histologically 1 week later to quantitate cell loss in the vulnerable CA-1 subsector of the hippocampus. In a separate set of experiments, 4 microg of ATA was administered intraventricularly 1 hour before ischemia and the brains were assessed for evidence of DNA fragmentation by the TUNEL method. There was only a 16% cell loss compared with nonischemic controls in animals pretreated with ATA that was significantly less (p < 0.05) than the 48% cell loss in animals pretreated with saline alone. TUNEL-positive cells were first evident at 3 days and were still present at 7 days subsequent to ischemia. Maximal staining occurred at 4 days. Pretreatment with ATA virtually eliminated TUNEL staining at 4 days. These results support the hypothesis that the delayed cell death secondary to transient ischemia is, in part, apoptotic. Furthermore, ATA afforded significant neuronal protection and prevented DNA fragmentation.