gebhart/patrepeval huggingface dataset:
The <i>Drosophila dead ringer</i> gene is required for early embryonic patterning through regulation of <i>argos</i> and <i>buttonhead</i> expression (1999)

The dead ringer (dri) gene of Drosophila melanogaster is a member of the recently discovered ARID-box family of eukaryotic genes that encode proteins with a conserved DNA binding domain. dri itself is highly conserved, with specific orthologs in the human, mouse, zebrafish and C. elegans genomes. We have generated dri mutant alleles to show that dri is essential for anterior-posterior patterning and for muscle development in the embryo. Consistent with the mutant phenotype and the sequence-specific DNA-binding properties of its product, dri was found to be essential for the normal early embryonic expression pattern of several key regulatory genes. In dri mutant embryos, expression of argos in the terminal domains was severely reduced, accounting for the dri mutant head phenotype. Conversely, buttonhead expression was found to be deregulated in the trunk region, accounting for the appearance of ectopic cephalic furrows. Curiously, dri was found also to be required for maintenance of expression of the ventrolateral region of even-skipped stripe four. This study establishes dri as an essential co-factor in the regulated expression of specific patterning genes during early embryogenesis.
A piece of my mind : editorial comment (2013)

you can expect from Piece - When (if) you read this column, you'll notice that there are times when I comment on what people have written, and there are times when I don't. There are other times when I focus on meetings that I have attended, or perhaps there are just random thoughts about things that strike me as being important, funny or sometimes possibly just interesting to me. The answer to What are you going to write about this month? is usually It depends. I certainly don't feel the urge to comment on every single thing in the SAPJ, and there are many times when I adopt a wait and see attitude - if it's important to you, you'll write to me. That is an essential aspect of the journal. It's here to inform you, to provide material for CPD, and to give you a platform to air your views. My views are really not important in your daily life.
Improving Manual Manufacturing with a Computer Based Laser Projection System (1993)

<div class="htmlview paragraph">The application of computers to manufacturing has been largely in the area of total automation. (CNC, robotics, etc.). This paper describes a computer based laser projection system which is currently in use in several specialized aerospace applications. The system delivers accurate dimensional information directly onto large (meters), complex work surfaces for manual manufacturing tasks. Most manual manufacturing processes can be dramatically improved by delivering electronic dimensional information (CAD data) accompanied by electronically based multi media work instructions directly to the person performing the work. The results of applying this system will be lower costs, higher quality and improved time to market for products which are manually prototyped or manufactured.</div>
Conformal array microwave applicator for superficial hyperthermia of large contoured surfaces (2002)

Local hyperthermia continues to offer great promise as an adjuvant to radiation and chemotherapy treatments for cancer but its clinical use is severely restricted by technical difficulties in producing adequate uniformity of heating. The authors describe the design and radiation field characteristics of a novel dual concentric conductor microwave radiator which may be combined into multi-aperture arrays for heating large contoured superficial tissue regions at 915 MHz. Power deposition patterns for single aperture and multi-element array applicators were quantified with detailed electric field measurements in tissue equivalent phantom models and with temperature distributions obtained during clinical treatments of human chestwall tumors. The data demonstrate that power deposition patterns measured in a plane 1 cm deep in muscle equivalent phantom material remain above approximately 50% of their peak value out to the perimeter of each 3.5-5 cm square aperture tested In addition, conformal arrays with up to 24 such apertures driven non-coherently can be used to heat large contoured human chestwall disease to acceptably uniform temperatures within the range of 41.5-44/spl deg/C, with improved patient tolerance compared to previously used bulky waveguide applicators. These new applicators offer improved utility in the clinic due to their thin flexible construction which allows the applicator to conform tightly but comfortably to complex surface contours. Planned improvements on this preliminary conformal array design will allow the delivery of external beam radiation directly through the applicator to take advantage of the improved synergism between simultaneously applied modalities.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Energy Efficient Inverse Power Control for a Cognitive Radio Link (2007)

In this paper, a novel adaptive energy and spectrum efficient inverse power control method that is based on the truncated filtered-x LMS (FxLMS) algorithm is introduced. By truncated power control we mean power control where transmission is interrupted if the channel state deteriorates to bad enough. Inverse power control minimizes the interference that a cognitive radio (CR) creates to licensed users and allows more users to share the spectrum. To further reduce the transmission power and consequently the interference, truncation in power control is used. The performance of the system is improved and the amount of needed transmitted energy is smaller. Based on numerical analysis this new method offers energy efficient transmission, helps to minimize interference to the primary users, and allows even more users to share the same spectrum.
PCB Rogowski coils benefit relay protection (2002)

Innovative Rogowski coils enable the design of advanced protection systems when used with new multifunction relays and fiberoptic communication. The protection systems have faster response times to faults and can easily adjust to load and/or power system configuration changes. Since the new Rogowski coils are very accurate and do not saturate, protection levels can be set to lower fault current thresholds, reducing the stress on the protected equipment. The whole system is immune to external magnetic fields and has self-testing logic. No wiring is necessary.
Greek and Roman poetics (1993)

In any modern discussion of tragedy, Aristotle almost always has some role to play, whether on center stage or whispering from the wings. But the Poetics was not known to Latin Antiquity, and it was badly misunderstood or neglected when it finally came to light in the thirteenth century. And since our present enterprise is primarily concerned not with what we think about tragedy (or with what we think Aristotle thought about tragedy), but rather with what was thought about tragedy in the Middle Ages, we shall not have to be much concerned with Aristotle's views.
Autophagy in the Pathogenesis of Pulmonary Disease (2013)

Autophagy is a process of lysosomal self-degradation that helps to maintain the homeostatic balance between the synthesis, degradation and recycling of cellular proteins and organelles. Autophagy does not simply function as the machinery for supplying amino acids in response to energy demands, it is an adaptive pathway of cytoprotection against cellular stressors, including starvation, reactive oxygen species (ROS), endoplasmic reticulum (ER) stress and microbial infection. Accordingly, autophagy is considered to be the mediator of a variety of cellular processes and cell fates, including cell survival and death, cellular senescence and immune responses. Due to the organ-specific role of gas exchange, various cell types within the lungs are serially exposed to a diverse array of cellular stressors, and growing evidence has revealed the crucial involvement of autophagy in the pathogenic processes underlying pulmonary diseases. We herein review recent findings regarding the role of autophagy in cellular processes and cell fates and summarize the role that autophagy appears to play in the pathogenesis of pulmonary diseases.
Cross-Talk between Two Cysteine Protease Families (2000)

Calpains and caspases are two cysteine protease families that play important roles in regulating pathological cell death. Here, we report that m-calpain may be responsible for cleaving procaspase-12, a caspase localized in the ER, to generate active caspase-12. In addition, calpain may be responsible for cleaving the loop region in Bcl-xL and, therefore, turning an antiapoptotic molecule into a proapoptotic molecule. We propose that disturbance to intracellular calcium storage as a result of ischemic injury or amyloid beta peptide cytotoxicity may induce apoptosis through calpain- mediated caspase-12 activation and Bcl-xL inactivation. These data suggest a novel apoptotic pathway involving calcium-mediated calpain activation and cross-talks between calpain and caspase families.
Calcium Oxalate Crystals in the Breast (1991)

Deposits of birefringent calcium oxalate crystals in the breast constitute a mammographically detectable but often histologically overlooked form of calcification. Unstained by routine dyes, these deposits are important as a cause of discrepant radiographic and microscopic biopsy findings. To elucidate the pathologic changes that give rise to these crystals and the possible significance of these deposits in the breast, we retrospectively studied 119 breast biopsies from 100 women. By polarized light microscopy, we identified 16 cases with calcium oxalate deposits from this group. The crystals were typically within benign cysts or terminal ductules exhibiting apocrine differentiation by conventional morphologic criteria or by immunoreactivity to monoclonal antibodies against gross cystic disease fluid protein of 1,500 MW (anti-GCDFP-15). The lesions harboring the crystals were papillary or cystic apocrine metaplasia in 14 cases and simple apocrine metaplasia in two cases. These lesions were associated with separate foci of lobular carcinoma in situ in three cases and with other proliferative lesions regarded as risk markers for invasive carcinoma in six other cases. Paradoxically, the crystals were rarely seen in association with infiltrating carcinomas. Our findings support the concept that calcium oxalate deposits are a secretory form of calcification. The association with lobular carcinoma in situ and the rarity of the crystals in invasive carcinomas are in accord with previous observations. We found polarized light microscopy indispensable for the demonstration of these deposits in hematoxylin-eosin-stained sections.
A Simplified Hyperbaric Oxygen Technique for Leg Ulcers (1984)

A modified technique for administering hyperbaric oxygen with the use of disposable polyethylene bags was evaluated for the treatment of arterial leg ulcers. The potential advantages of the method include fairly low expense, lack of cross-infection, and simplicity in the administration of oxygen. Six men with 27 chronic arterial ulcers were treated with this technique, and five men (ten ulcers) served as controls. In the treated group, 18 of 27 ulcers (5/6 patients) were healed within six to 21 days, with 50% to 90% reduction in size of seven of nine of the remaining ulcers after a three-week period. None were healed in the control group. The treated ulcers healed by 7.8% +/- 1.15% per day compared with -0.5% +/- 0.37% in the control patients. The results indicate that our technique of administering hyperbaric oxygen for the treatment of leg ulcers is simple and effective. It can be adapted for either inpatient or outpatient treatment.
High Speed Holographic Digital Recorder (1974)

Concepts, feasibility experiments, and key component developments are described for a holographic digital record/reproduce system with the potential for 1.0 Gbit/sec rates and higher. Record rates of 500 Mbits/sec have been demonstrated with a ten-channel acoustooptic modulator array and a mode-locked, cavity-dumped argon-ion laser. Acoustooptic device technology has been advanced notably during the development of mode lockers, cavity dumpers, beam deflectors, and multichannel modulator arrays. The development of high speed multichannel photodetector arrays for the readout subsystem requires special attention. The feasibility of 1.0 Gbits/sec record rates has been demonstrated.
Immobilization of bioactive peptides on benzocyclobutene (BCB) surface grafted-dextran for neural implant applications (2004)

In vitro cell adhesion and neurite growth on dextran-coated benzocyclobutene (BCB) films, covalently grafted with bioactive peptides are investigated. For cell/tissue adhesive surfaces, synthetic peptide GRGDSP was employed. GRADSP was used as an inactive control for nonspecific peptide-induced cell adhesion. For surface coatings with neurite growth-promoting activity, the laminin-based peptide SRARKQAASIKVAVSADR was utilized. Three cell lines were utilized in these studies. The cell cultures investigated in this study were 3T3 fibroblasts, neuronal-like PC 12 cells, and a glial-like (glioblastoma) T98-G cell line. Chemical composition of all modified surfaces was verified by X-ray photoelectron spectroscopy (XPS). Our non-toxic aqueous methods to graft cell adhesion peptides on dextran monolayer surfaces, effectively limited non-specific cell adhesion and neurite growth in the presence of cultured cells. Microscopic visualization and imaging of these surfaces showed that dextran coatings promoted essentially no adhesion of all cell lines tested. Surface-grafted cell adhesion RGD peptides stimulated fibroblast and glial cell adhesion with minimal neuronal PC12/spl I.bar/cell attachment and spreading in vitro. In contrast, surface-grafted inactive RAD peptide sequences did not promote significant cell interaction of all cell types indicating that peptide-grafted surfaces did not promote non-specific cell adhesion. Surface-grafted high affinity IKVAV peptides promoted cell type-dependent interactions. The IKVAV-grafted surfaces also promoted neurite growth on all substrates.
Actuation of atomic force microscope cantilevers in fluids using acoustic radiation pressure (2003)

Actuation of microcantilevers in fluids has applications such as atomic force microscopy, fluid mixing and mechanical property characterization in microchannels. In this paper of a microfluidic actuator, which utilizes acoustic radiation pressure (ARP) to exert DC and AC forces on a microcantilever is discussed. An atomic force microscope (AFM) cantilever has been used to demonstrate the capabilities of this actuator. The method allows the application of a localized force at a desired location on a cantilever with a 5 MHz bandwidth. The localized nature of the applied force allows the characterization of flexural and torsional oscillation modes of the AFM cantilevers. Tapping mode atomic force microscopy was also carried out using the ARP actuator.
ACTIVIDAD ANTIMICROBIANA Y ANTITUMORAL DE LA VARIABILINA Y SUS ENANTIOMEROS AISLADOS DE Ircinia felix (2001)

El presente trabajo muestra un amplio espectro antimicrobiano para la variabilina y sus enantiomeros siendo activos contra los microorganismos Gram (+) Micrococcus luteus, Staphylococcus aureus y Bacillus subtilis y los microorganismos Gram (-) Pseudomonas sp, Enterobacter aerogenes y Escherichia coli. Los compuestos no mostraron actividad contra los hongos Aspergillus tamari, Aspergillus niger y Penicillium sp, en las concentraciones ensayadas. El efecto antitumoral en disco de zanahoria se observó a una concentración de 2.5 Î¼g/mL, mientras que la concentración inhibitoria de los tumores fue determinada a un valor de 18.0 Î¼g/mL, además se encontró que la concentración letal CL50 en Artemia salina es 272.0 Î¼g/mL.
Human hHpr1/p84/Thoc1 Regulates Transcriptional Elongation and Physically Links RNA Polymerase II and RNA Processing Factors (2005)

Cotranscriptional loading of RNA processing factors onto nascent RNA facilitates efficient gene expression. Mechanisms responsible for coupling transcription and RNA processing are not well defined, but the Saccharomyces cerevisiae TREX complex provides an example. TREX is composed of the subcomplex THO that associates with RNA polymerase II and is required for normal transcriptional elongation. THO associates with proteins involved in RNA splicing and export to form the larger TREX complex. Hence, assembly of TREX physically couples transcriptional elongation with RNA processing factors. Whether metazoan species with long, intron-containing genes utilize a similar mechanism has not been established. Here we show that human hHpr1/p84/Thoc1 associates with elongating RNA polymerase II and the RNA splicing and export factor UAP56 in intact cells. Depletion of hHpr1/p84/Thoc1 causes transcriptional elongation defects and associated cellular phenotypes similar to those observed in THO-deficient yeast. We conclude that hHpr1/p84/Thoc1 regulates transcriptional elongation and may participate in a protein complex functionally analogous to yeast TREX, physically linking elongating RNA polymerase II with RNA processing factors.
The Spatial Distribution of Precipitation in Northwest China (2014)

Northwestern China has an extremely complex climate due to the varied terrain and complexities of climate change where the environment is sensitive to both regional and global climate change. We employed the Mann-Kendal test to investigate trends of precipitation distributions using annual, seasonal, and monthly data records from 1960 to 2008. On the whole, the variations in precipitation patterns are more complex than those for temperature. The trends of annual, seasonal, and monthly precipitation have shown remarkable differences between the east and west. In the west such as in northern Xinjiang and western Qinghai, the variation is a significant increase, consistent with the temperature change, whereas in the east such as in eastern Gansu, and southern Shaanxi, the variation is a remarkable decrease, opposite to the change observed in temperatures.
Method for detecting the extent of the melting layer (1998)

Comparisons of current melting band detection techniques applied to hundreds of CAMRa RHI scans have revealed differences in estimating the width of the melting band as high as 600 m. The authors present a more accurate method for the determination of the width of the melting band and the implications for attenuation modelling of earth-space communication paths are discussed.
CMOS 3-T digital pixel sensor with in-pixel shared comparator (2012)

A CMOS digital pixel sensor (DPS) VLSI architecture with in-pixel one-bit quantization is presented. A single column-parallel comparator is shared by all pixels in the column. This results in a compact 3-T pixel implementation. By eliminating the in-pixel source follower the pixel effective power dissipation is reduced by over two orders of magnitude compared to a conventional 3-T pixel. A 64×64 DPS test prototype with 10μm pixel pitch has been fabricated in 0.35μm standard CMOS and experimentally characterized.
Adipose Tissue Immune Response: Novel Triggers and Consequences for Chronic Inflammatory Conditions (2014)

Adipose tissue inflammation mediates the association between excessive body fat accumulation and several chronic inflammatory diseases. A high prevalence of obesity-associated adipose tissue inflammation was observed not only in patients with cardiovascular conditions but also in patients with inflammatory bowel diseases, abdominal aortic aneurysm, or cardiorenal syndrome. In addition to excessive caloric intake, other triggers promote visceral adipose tissue inflammation followed by chronic, low-grade systemic inflammation. The infiltration and accumulation of immune cells in the inflamed and hypertrophied adipose tissue promote the production of inflammatory cytokines, contributing to target organ damages. This comorbidity seems to delimit subgroups of individuals with systemic adipose tissue inflammation and more severe chronic inflammatory diseases that are refractory to conventional treatment. This review highlights the association between adipose tissue immune response and the pathophysiology of visceral adiposity-related chronic inflammatory diseases, while suggesting several new therapeutic strategies.
Spectroscopic Measurements in Oil Sands Industry-From Laboratories to Real-time Applications (2015)

This article presents an overview of the principle, engineering implementation and applications of spectroscopic measurements technology, such as NIR (near infrared), FTIR (Fourier transform infrared), Raman and NMR (nuclear magnetic resonance). The discussions are focused on oil sands industry in which the process majorly consists of the mining, slurry hydro-transport, extraction, froth treatment and upgrading plants.
Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution (2015)

Group II introns are remarkable mobile retroelements that use the combined activities of an autocatalytic RNA and an intron-encoded reverse transcriptase (RT) to propagate efficiently within genomes. But perhaps their most noteworthy feature is the pivotal role they are thought to have played in eukaryotic evolution. Mobile group II introns are ancestrally related to nuclear spliceosomal introns, retrotransposons and telomerase, which collectively comprise more than half of the human genome. Additionally, group II introns are postulated to have been a major driving force in the evolution of eukaryotes themselves, including for the emergence of the nuclear envelope to separate transcription from translation.
Narrowband channel extraction for wideband receivers (1999)

One of the most computationally intensive processing stages of a wideband digital receiver is the extraction of a narrowband channel from a wideband input signal. In implementations that compute the convolutional sum, the computation is proportional to the bandwidth of the input signal. This paper shows how to break this dependence, reducing the limiting factor to the requirement to maintain a sufficient output signal-to-noise ratio (SNR). This paper describes two complementary algorithms for efficient channel extraction in wideband receivers. The first allows the required frequency translation to be performed at the lower sample rate of the channel filter output. The second algorithm decouples the effect of interference rejection from the SNR improvement and improves the computational efficiency of filtering by using only a subset of the input samples. Additionally, we present a simple model to quantify the effects of this technique and experimental verification using a wideband software radio receiver.