gebhart/patrepeval huggingface dataset:
Trust based Secure Reliable Route Discovery in Wireless Mesh Networks (2019)

Secured and reliable routing is a crucial factor for improving the performance of Wireless Mesh Networks (WMN) since these networks are susceptible to many types of attacks. The existing assumption about the internal nodes in wireless mesh networks is that they cooperate well during the forwarding of packets all the time. However, it is not always true due to the presence of malicious and mistrustful nodes. Hence, it is essential to establish a secure, reliable and stable route between a source node and a destination node in WMN. In this paper, a trust based secure routing algorithm is proposed for enhancing security and reliability of WMN, which contains cross layer and subject logic based reliable reputation scheme with security tag model for providing effective secured routing. This model uses only the trusted nodes with the forwarding reliability of data transmission and it isolates the malicious nodes from the providing path. Moreover, every node in this model is assigned with a security tag that is used for efficient authentication. Thus, by combining authentication, trust and subject logic, the proposed approach is capable of choosing the trusted nodes effectively to participate in forwarding the packets of trustful peer nodes successfully. The simulation results obtained from this work show that the proposed routing protocol provides optimal network performance in terms of security and packet delivery ratio.
[Effects of surgical treatment on circadian variations of arterial pressure in patients with primary aldosteronism and renovascular hypertension]. (1990)

Noninvasive recording of blood pressure (BP) with a portable Del Mar Avionics monitor (USA) revealed its abnormal circadian rhythm in patients with renovascular hypertension or arterial hypertension caused by adrenal aldosteroma. Surgical treatment was shown to result in a significant decrease in blood pressures and normalization of its circadian rhythm in the early postoperative period.
1/4-&#181;m CMOS isolation technique using selective epitaxy (1987)

A new CMOS isolation technique has been developed for reducing isolation width to a 1/4 µm with large latchup immunity. This technique is supported by three key processes. The first is to form 1/4 µm thick insulator films on trench sidewalls, which are shaped perpendicularly to the substrate surface plane. The second is to refill the trenches with selectively grown single-crystal silicon with a planar surface. The third is to form a low-resistance well for latchup prevention. The CMOS devices are composed of n-channel devices fabricated on a p-type substrate and p-channel devices fabricated on an n-type epi-layer. In this isolation structure, a parasitic MIS operation with vertical channel induces large leakage currents along the isolation sidewalls. However, the highly doped p-type region, due to deep boron implant in the p-type substrate, is effective to suppress parasitic operation. Submicrometer-gate CMOS inverter operation is shown, when the channel stop implant is carried out.
The Hutterian Brethren By John Horsch. Goshen, Indiana: Mennonite Historical Society, 1931. 168 pages. $2.00. (1933)

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Predicted Very Large Thermoelectric Effect in Ferromagnet-Superconductor Junctions in the Presence of a Spin-Splitting Magnetic Field (2014)

We show that a huge thermoelectric effect can be observed by contacting a superconductor whose density of states is spin split by a Zeeman field with a ferromagnet with a nonzero polarization. The resulting thermopower exceeds kB/e by a large factor, and the thermoelectric figure of merit ZT can far exceed unity, leading to heat engine efficiencies close to the Carnot limit. We also show that spin-polarized currents can be generated in the superconductor by applying a temperature bias.
Xanthones from Mangosteen Extracts as Natural Chemopreventive Agents: Potential Anticancer Drugs (2011)

Despite decades of research, the treatment and management of malignant tumors still remain a formidable challenge for public health. New strategies for cancer treatment are being developed, and one of the most promising treatment strategies involves the application of chemopreventive agents. The search for novel and effective cancer chemopreventive agents has led to the identification of various naturally occurring compounds. Xanthones, from the pericarp, whole fruit, heartwood, and leaf of mangosteen (Garcinia mangostana Linn., GML), are known to possess a wide spectrum of pharmacologic properties, including antioxidant, anti- tumor, anti-allergic, anti-inflammatory, anti-bacterial, anti-fungal, and anti-viral activities. The potential chemopreventive and chemotherapeutic activities of xanthones have been demonstrated in different stages of carcinogenesis (initiation, promotion, and progression) and are known to control cell division and growth, apoptosis, inflammation, and metastasis. Multiple lines of evidence from numerous in vitro and in vivo studies have confirmed that xanthones inhibit proliferation of a wide range of human tumor cell types by modulating various targets and signaling transduction pathways. Here we provide a concise and comprehensive review of preclinical data and assess the observed anticancer effects of xanthones, supporting its remarkable potential as an anticancer agent.
Potentiation of the anti-tumor effect of actinomycin D by tumor necrosis factor α in mice: Correlation betweenin vitro andin vivo results (1996)

The anti-tumor effects of actinomycin D (Act D) and recombinant human tumor necrosis factor (TNF)-alpha have been studied on 4 established murine tumor cell lines: MmB16 melanoma, Lewis lung (LL/2) carcinoma, L1 sarcoma and L1210 leukemia. During short-term incubation (24 hr) Act D produced dose-dependent cytostatic/cytotoxic effects against MmB16, LL/2 and L1 tumor cells but did not reduce the viability of these cells even at high concentration (10 micrograms/ml), below a threshold of 30-60%. However, L1210 leukemic cells were highly susceptible to Act D, and no viable cells were detected in cultures incubated with 1 microgram/ml of Act D. TNF-alpha alone, when used under the same culture conditions, had only a negligible effect on all cell lines tested. However, the combination of this cytokine with Act D produced synergistic cytotoxic effects against MmB16, LL/2 and L1 cells but not against L1210 leukemia cells. In an in vivo model of regional therapy in which tumor-bearing mice were treated with Act D and TNF-alpha, a correlation with in vitro results was observed. In mice bearing MmB16 melanoma, LL/2 carcinoma and L1 sarcoma, the most potent anti-tumor effects were observed in mice treated with Act D and TNF-alpha together. This treatment led to a delay of tumor growth and induced complete tumor regression in some cases. On the contrary, TNF-alpha did not enhance the effect of Act D in mice injected with L1210 leukemia cells. Our results show that TNF-alpha can potentiate the anti-tumor effects of Act D against tumors weakly susceptible to Act D and may be a useful adjuvant to chemotherapy in the local treatment of neoplasia.
Increased polymerase fidelity of lamivudine-resistant HIV-1 variants does not limit their evolutionary potential (1999)

This study demonstrates that the Met184Val and Met184Ile mutations in the HIV-1 reverse transcriptase enzyme do not significantly affect the evolutionary potential of the corresponding viruses.
Evolution of a novel subfamily of nuclear receptors with members that each contain two DNA binding domains (2007)

2DBD-NRs share a common ancestor gene which possessed an extra DBD that likely resulted from a recombination event. After the split of the Arthropods, Mollusks and Platyhelminths, 2DBD-NR underwent a recent duplication in a common ancestor of Mollusks, while two rounds of duplication occurred in a common ancestor of the Platyhelminths. This demonstrates that certain NR gene underwent recent duplication in Prostostome lineages after the split of the Prostostomia and Deuterostomia.
Traitement des signaux parcimonieux et applications (2012)

Quel que soit le domaine d'application, il est necessaire de tirer profit de toute l'information a priori dans le but d'optimiser les resultats ou parfois meme de maniere a rendre un probleme soluble. Dans ce contexte, la notion de parcimonie a emerge comme un a priori fondamental ces dernieres annees. On dit qu'un signal est parcimonieux dans une base s'il peut etre decrit par un faible nombre de coefficients non nuls dans cette base. L'objet de cette these est l'etude de nouveaux apports de l'hypothese de parcimonie au traitement du signal. Deux domaines d'applications sont consideres. Outre l'utilisation de la parcimonie, ces deux domaines ont en commun la resolution de problemes inverses sous-determines. Le premier concerne la separation de sources. Dans ce domaine, la parcimonie a conduit au developpement de differentes methodes de separation de sources. Les performances de ces methodes sont sensibles au choix de certains parametres, habituellement choisis de maniere empirique. Dans cette these, on propose un formalisme statistique qui permet de reduire le nombre de ces parametres, tout en preservant la qualite de la separation. Le second domaine d'application etudie est l'acquisition compressee des signaux a alphabet fini. Une telle acquisition compressee permet de reduire la dimension des signaux a alphabet fini, tout en gardant l'information necessaire a leur reconstruction. Une formalisation du probleme permet de le relier a celui de la reconstruction des signaux parcimonieux a partir de mesures incompletes. Cette these est donc une exploration de nouvelles problematiques ou l'integration de la parcimonie conduit a de bonnes performances.
Control System Development for an Advanced-Technology Medium-Duty Hybrid Electric Truck (2003)

<div class="htmlview paragraph">The power management control system development and vehicle test results for a medium-duty hybrid electric truck are reported in this paper. The design procedure adopted is a model-based approach, and is based on the dynamic programming technique. A vehicle model is first developed, and the optimal control actions to maximize fuel economy are then obtained by the dynamic programming method. A near-optimal control strategy is subsequently extracted and implemented using a rapid-prototyping control development system, which provides a convenient environment to adjust the control algorithms and accommodate various I/O configurations. Dynamometer-testing results confirm that the proposed algorithm helps the prototype hybrid truck to achieve a 45% fuel economy improvement on the benchmark (non-hybrid) vehicle. It also compares favorably to a conventional rule-based control method, which only achieves a 31% fuel economy improvement on the same hybrid vehicle.</div>
CD8 T Cell Recognition of Endogenously Expressed Epstein-Barr Virus Nuclear Antigen 1 (2004)

The Epstein-Barr virus (EBV) nuclear antigen (EBNA)1 contains a glycine-alanine repeat (GAr) domain that appears to protect the antigen from proteasomal breakdown and, as measured in cytotoxicity assays, from major histocompatibility complex (MHC) class I-restricted presentation to CD8+ T cells. This led to the concept of EBNA1 as an immunologically silent protein that although unique in being expressed in all EBV malignancies, could not be exploited as a CD8 target. Here, using CD8+ T cell clones to native EBNA1 epitopes upstream and downstream of the GAr domain and assaying recognition by interferon gamma release, we show that the EBNA1 naturally expressed in EBV-transformed lymphoblastoid cell lines (LCLs) is in fact presented to CD8+ T cells via a proteasome/peptide transporter-dependent pathway. Furthermore, LCL recognition by such CD8+ T cells, although slightly lower than seen with paired lines expressing a GAr-deleted EBNA1 protein, leads to strong and specific inhibition of LCL outgrowth in vitro. Endogenously expressed EBNA1 is therefore accessible to the MHC class I pathway despite GAr-mediated stabilization of the mature protein. We infer that EBNA1-specific CD8+ T cells do play a role in control of EBV infection in vivo and might be exploitable in the control of EBV+ malignancies.
Simulations of a LiF Solid Electrolyte Interphase Cracking on Silicon Anodes Using Molecular Dynamics (2018)

The main advantage of silicon-based anodes for lithium-ion batteries is their high volumetric and gravimetric capacity to store Li. However, swelling upon lithiation causes cracks on the anode protective solid electrolyte interphase (SEI), creating channels for the electrolyte to enter and disturb the anode, leading to capacity fading, short- or open-circuit failures. We study the mechanical properties of LiF as a model SEI layer of a SiLi nanoparticle (NP) swollen by a time-dependent expanding potential (TDEP) simulating the lithiation of Si. The stress on the SEI increases until reaching its maximum at LiF bond breaking and cracking onsets. Then, stress decreases and the number of bonds in the SEI approaches a minimum, confirming the cracking. However, at the lowest currents, atoms have enough relaxation time that a surface reconstruction is observed and the stress reaches a second and higher maximum, then the SEI layer breaks into pieces. The microscopic amorphization mechanism is found to be independent of the charging rate; however, the value of the tensile strength depends on the expanding rate. LiF bonds breaking begins with those nearest to the SiLi-LiF interface, along a radial direction, then forming larger LiF rings until the SiLi alloy loses its protective shell
Total Structure Determination of Apratoxin A, a Potent Novel Cytotoxin from the Marine Cyanobacterium <i>Lyngbya </i><i>m</i><i>ajuscula</i> (2001)

Apratoxin A (1), a potent cytotoxin with a novel skeleton, has been isolated from the marine cyanobacterium Lyngbya majuscula Harvey ex Gomont. This cyclodepsipeptide of mixed peptide-polyketide biogenesis bears a thiazoline ring flanked by polyketide portions, one of which possesses an unusual methylation pattern. Its gross structure has been elucidated by spectral analysis, including various 2D NMR techniques. The absolute configurations of the amino acid-derived units were determined by chiral HPLC analysis of hydrolysis products. The relative stereochemistry of the new dihydroxylated fatty acid unit, 3,7-dihydroxy-2,5,8,8-tetramethylnonanoic acid, was elucidated by successful application of the J-based configuration analysis originally developed for acyclic organic compounds using carbon-proton spin-coupling constants ((2,3)J(C,H)) and proton-proton spin-coupling constants ((3)J(H,H)); its absolute stereochemistry was established by Mosher analysis. The conformation of 1 in solution was mimicked by molecular modeling, employing a combination of distance geometry and restrained molecular dynamics. Apratoxin A (1) possesses IC(50) values for in vitro cytotoxicity against human tumor cell lines ranging from 0.36 to 0.52 nM; however, it was only marginally active in vivo against a colon tumor and ineffective against a mammary tumor.
<i>Cis</i>-regulatory Changes at<i>FLOWERING LOCUS T</i>Mediate Natural Variation in Flowering Responses of<i>Arabidopsis thaliana</i> (2009)

Flowering time, a critical adaptive trait, is modulated by several environmental cues. These external signals converge on a small set of genes that in turn mediate the flowering response. Mutant analysis and subsequent molecular studies have revealed that one of these integrator genes, FLOWERING LOCUS T (FT), responds to photoperiod and temperature cues, two environmental parameters that greatly influence flowering time. As the central player in the transition to flowering, the protein coding sequence of FT and its function are highly conserved across species. Using QTL mapping with a new advanced intercross-recombinant inbred line (AI-RIL) population, we show that a QTL tightly linked to FT contributes to natural variation in the flowering response to the combined effects of photoperiod and ambient temperature. Using heterogeneous inbred families (HIF) and introgression lines, we fine map the QTL to a 6.7 kb fragment in the FT promoter. We confirm by quantitative complementation that FT has differential activity in the two parental strains. Further support for FT underlying the QTL comes from a new approach, quantitative knockdown with artificial microRNAs (amiRNAs). Consistent with the causal sequence polymorphism being in the promoter, we find that the QTL affects FT expression. Taken together, these results indicate that allelic variation at pathway integrator genes such as FT can underlie phenotypic variability and that this may be achieved through cis-regulatory changes.
Cost Effective Swath Bathymetry (2001)

Between 23rd and 25th July 2001 GeoSwath, a high specification shallow water wide swath bathymetry system, was used to survey the entire Portsmouth NH Harbor area. This paper deals with the results of this survey, illustrating the potential for significant reductions in the high costs, which have prevented widespread proliferation of Swath Bathymetry systems to date. Data, including a complete DTM gridded to 1 m resolution, will be presented and discussed in detail. These results show that the system is very easy to set up and use, requires greatly reduced boat and processing time, whilst offering high accuracy and very high coverage and resolution when used in a real-world survey of a dynamic harbor environment.
Highly conductive PEDOT:PSS films prepared through a treatment with zwitterions and their application in polymer photovoltaic cells (2010)

This paper reports the significant conductivity enhancement of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) films through a treatment with aqueous solutions of zwitterions for the first time. The conductivity enhancement was dependent on the structure of the zwitterions and the experimental conditions during the treatment, such as the concentration of the zwitterions and the temperature. Conductivity enhancement from 0.2 to 92.4 S cm−1 was observed on PEDOT:PSS films after a zwitterion treatment. The chemical and physical characterizations indicate the lowering of the energy barrier for charge hopping across the PEDOT chains, the loss of poly(styrene sulfonate) acid (PSSH) chains from the PEDOT:PSS film, and the conformational change of the PEDOT chains after the zwitterion treatment. These highly conductive PEDOT:PSS films could be used to replace indium tin oxide (ITO) as the transparent anode of polymer photovoltaic cells (PVs). Power conversion efficiency as high as 2.48% was observed on the polymer PVs with a zwitterion-treated PEDOT:PSS film as the transparent anode.
Two-finger input with a standard touch screen (2007)

Most current implementations of multi-touch screens are still too expensive or too bulky for widespread adoption. To improve this situation, this work describes the electronics and software needed to collect more data than one pair of coordinates from a standard 4-wire touch screen. With this system, one can measure the pressure of a single touch and approximately sense the coordinates of two touches occurring simultaneously. Naturally, the system cannot offer the accuracy and versatility of full multi-touch screens. Nonetheless, several example applications ranging from painting to zooming demonstrate a broad spectrum of use.
Inverted-repeats-aware finite-context models for DNA coding (2008)

Finite-context models have been used for DNA sequence compression as secondary, fall back mechanisms, the generalized opinion being that models with order larger than two or three are inappropriate. In this paper we show that finite-context models can also be used as the main encoding method, and that they are effective for model orders at least as higher as thirteen. Moreover, we propose a new model updating scheme that takes into account inverted repeats, a common characteristic in DNA sequences.
Effect of yttrium dopping on the ferroelectric fatigue and switching characteristics of Pb(Zr<sub>0.65</sub>Ti<sub>0.35</sub>)O<sub>3</sub> thin films prepared by sol-gel processing (1995)

Abstract Variations of remanent polarization and coercive field of undoped and yttrium doped Pb(Zr0.65Ti0.35)O3 thin films prepared by Sol-Gel processing were observed using hysteresis measurement according to the cumulative switching cycles. Remanent polarization and coercive field of undoped Pb(Zr0.65Ti0.35)O3 thin films after 1010 polarization reversals were decreased and increased, respectively. But the variations of remanent polarization and coercive field of yttrium doped specimens with the polarization switching cycles were different from those of undoped specimens. In the case of yttrium doped specimens, remanent polarizations were not decreased and coercive fields were increased more than those of undoped specimens after fatigue. It was well known that doped yttrium reduced holes and increased vacancies in PZT thin films. This strongly suggests that the variations of holes and vacancies influence on the remanent polarizations and the coercive fields of Pb(Zr0.65Ti0.35)O3 thin films after fatigue. Also, switching time was reduced as the yttrium doping increased.
Tau pathology: a marker of neurodegenerative disorders (2000)

Tau is not only a basic component of neurofibrillary degeneration, but is also an aetiological factor, as demonstrated by mutations on the tau gene responsible for frontotemporal dementias with parkinsonism linked to chromosome 17. Polymorphisms on the tau gene and the hierarchical invasion of neocortical areas by tau pathology in numerous sporadic neurodegenerative diseases also suggest that tau pathology is a primary pathogenic event in non-familial dementing diseases and a lead for solid diagnostic and therapeutic approaches.
Spectral response of electron-irradiated homoepitaxial InP solar cells (1996)

The Naval Research Laboratory has presented numerous reports on the radiation hardening of the two-terminal InP/Ga/sub 0.47/In/sub 0.53/As tandem solar cells for space use. To date, most work has been done on n/sup +/p devices. However, in order to facilitate the heteroepitaxial growth of these tandems on substrates such as Si or Ge, the polarity of the subcells may need to be reversed. With this in mind, spectral response measurements on irradiated homoepitaxial p/sup +/n InP solar cells were carried out for several fluences of 1 MeV electrons. The quantum efficiency data degraded at high wavelengths but no significant degradation was observed at low wavelengths. An important material parameter in solar cell devices is the minority carrier diffusion length (L) for which L/sub P/ was measured in the present study. This parameter was measured as a function of electron irradiation using the steady-state short-circuit current method. The degradation of L/sub P/ was plotted as a function of electron fluence and the data were fit to the standard semi-empirical model which relates /spl Delta/L to the damage constant, K/sub L/. The fit yielded values for K/sub L/ and the unirradiated minority carrier diffusion length, L/sub 0/.
S-, C- and L-band continuously tunable fiber laser using thulium- and erbium-doped fibers (2005)

A hybrid-cavity fiber laser using thulium-doped fluoride fiber and erbium-doped fiber presents a narrow linewidth that can be continuously tuned in the S, C and L bands, from 1445 nm to 1590 nm.