gebhart/patrepeval huggingface dataset:
Failure to diagnose acute myocardial infarction. The clinicopathologic experience at a large community hospital. (1983)

A retrospective study of 100 consecutive cases of autopsy-proved acute myocardial infarction has disclosed a surprisingly low frequency (53%) of correct antemortem diagnoses. Incorrect diagnoses seemed to be caused by (1) unjustified dependence on misleading laboratory studies, (2) inattention to suggestive or diagnostic laboratory studies, (3) atypical or obscure presentation of myocardial infarction, and (4) failure to consider acute myocardial infarction as a diagnostic possibility, particularly when the responsible physician was not a specialist in internal medicine or its subspecialty of cardiology. Suggested corrective measures are a more appropriate use of the ECG and the laboratory and education and reeducation of selected groups of physicians.
Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane (2015)

Gene therapy, used to achieve functional recovery from sensorineural deafness, promises to grant better understanding of the underlying molecular and genetic mechanisms that contribute to hearing loss. Introduction of vectors into the inner ear must be done in a way that widely distributes the agent throughout the cochlea while minimizing injury to the existing structures. This manuscript describes a post-auricular surgical approach that can be used for mouse cochlear therapy using molecular, pharmacologic, and viral delivery to mice postnatal day 10 and older via the round window membrane (RWM). This surgical approach enables rapid and direct delivery into the scala tympani while minimizing blood loss and avoiding animal mortality. This technique involves negligible or no damage to essential structures of the inner and middle ear as well as neck muscles while wholly preserving hearing. To demonstrate the efficacy of this surgical technique, the vesicular glutamate transporter 3 knockout (VGLUT3 KO) mice will be used as an example of a mouse model of congenital deafness that recovers hearing after delivery of VGLUT3 to the inner ear using an adeno-associated virus (AAV-1).
Prehistoric Textiles (1991)

This pioneering work revises our notions of the origins and early development of textiles in Europe and the Near East. Using innovative linguistic techniques, along with methods from palaeobiology and other fields, it shows that spinning and pattern weaving began far earlier than has been supposed. Prehistoric Textiles made an unsurpassed leap in the social and cultural understanding of textiles in humankind's early history. Cloth making was an industry that consumed more time and effort, and was more culturally significant to prehistoric cultures, than anyone assumed before the book's publication. The textile industry is in fact older than pottery--and perhaps even older than agriculture and stockbreeding. It probably consumed far more hours of labor per year, in temperate climates, than did pottery and food production put together. And this work was done primarily by women. Up until the Industrial Revolution, and into this century in many peasant societies, women spent every available moment spinning, weaving, and sewing. The author, Elizabeth Wayland Barber, demonstrates command of an almost unbelievably disparate array of disciplines--from historical linguistics to archaeology and paleobiology, from art history to the practical art of weaving. Her passionate interest in the subject matter leaps out on every page. Barber, a professor of linguistics and archaeology, developed expert sewing and weaving skills as a small girl under her mother's tutelage. One could say she had been born and raised to write this book. Because modern textiles are almost entirely made by machines, we have difficulty appreciating how time-consuming and important the premodern textile industry was. This book opens our eyes to this crucial area of prehistoric human culture.
Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells (2007)

HTLV-1 (human T-cell leukaemia virus type 1) is the causative agent for ATL (adult T-cell leukaemia). HTLV-1 Tax can activate the PI3K (phosphoinositide 3-kinase)/Akt signalling pathway, which is responsible for survival of HTLV-1-infected T-cells. HIFs (hypoxia-inducible factors) are transcriptional regulators that play a central role in the response to hypoxia. Overexpression of HIF-1alpha in many cancers is associated with a poor response to treatment and increased patient mortality. Our objectives in the present study were to investigate whether HIF-1 was activated in HTLV-1-infected T-cells and to elucidate the molecular mechanisms of HIF-1 activation by focusing on the PI3K/Akt signalling pathway. We detected a potent pathway that activated HIF-1 in the HTLV-1-infected T-cells under a normal oxygen concentration. Enhanced HIF-1alpha protein expression and HIF-1 DNA-binding activity were exhibited in HTLV-1-infected T-cell lines. Knockdown of HIF-1alpha by siRNA (small interfering RNA) suppressed the growth and VEGF (vascular endothelial growth factor) expression of the HTLV-1-infected T-cell line. HIF-1 protein accumulation and transcriptional activity were enhanced by Tax, which was inhibited by dominant-negative Akt. Importantly, mutant forms of Tax that are defective in activation of the PI3K/Akt pathway failed to induce HIF-1 transcriptional activity. The PI3K inhibitor LY294002 suppressed HIF-1alpha protein expression, HIF-1 DNA-binding and HIF-1 transcriptional activity in HTLV-1-infected T-cell lines. In primary ATL cells, HIF-1alpha protein levels were strongly correlated with levels of phosphorylated Akt. The results of the present study suggest that PI3K/Akt activation induced by Tax leads to activation of HIF-1. As HIF-1 plays a major role in tumour progression, it may represent a molecular target for the development of novel ATL therapeutics.
Ionic permeation and blockade in Ca2+-activated K+ channels of bovine chromaffin cells. (1984)

Single channel currents through Ca2+-activated K+ channels of bovine chromaffin cells were measured to determine the effects of small ions on permeation through the channel. The channel selects strongly for K+ over Na+ and Cs+, and Rb+ carries a smaller current through the channel than K+. Tetraethylammonium ion (TEA+) blocks channel currents when applied to either side of the membrane; it is effective at lower concentrations when applied externally. Millimolar concentrations of internal Na+ reduce the average current through the channel and produce large fluctuations (flicker) in the open channel currents. This flickery block is analyzed by a new method, amplitude distribution analysis, which can measure block and unblock rates in the microsecond time range even though individual blocking events are not time-resolved by the recording system. The analysis shows that the rate of block by Na+ is very voltage dependent, but the unblock rate is voltage independent. These results can be explained easily by supposing that current flow through the channel is diffusion limited, a hypothesis consistent with the large magnitude of the single channel current.
Extremely sharp carbon nanocone probes for atomic force microscopy imaging (2006)

A simple and reliable catalyst patterning technique combined with electric-field-guided growth is utilized to synthesize a sharp and high-aspect-ratio carbon nanocone probe on a tipless cantilever for atomic force microscopy. A single carbon nanodot produced by an electron-beam-induced deposition serves as a convenient chemical etch mask for catalyst patterning, thus eliminating the need for complicated, resist-based, electron-beam lithography for a nanoprobe fabrication. A gradual, sputtering-induced size reduction and eventual removal of the catalyst particle at the probe tip during electric-field-guided growth creates a sharp probe with a tip radius of only a few nanometers. These fabrication processes are amenable for the wafer-scale synthesis of multiple probes. High resolution imaging of three-dimensional features and deep trenches, and mechanical durability enabling continuous operation for many hours without noticeable image deterioration have been demonstrated.
In vivo and in vitro complexes of activated protein C with two inhibitors in baboons (1991)

In vivo complex formation of activated protein C with protein C inhibitor (APC-PCI) and with alpha 1-antitrypsin (APC-alpha 1AT) following infusion of 0.25 or 1.0 mg APC/kg in 1 hour into baboons was studied using immunoblotting and sandwich enzyme-linked immunosorbent assay (ELISA)s. Before APC infusion, detectable plasma levels (about 30 ng/mL) of APC-alpha 1AT complex were found in the baboon plasma. At the lower APC dose, APC-PCI and APC-alpha 1AT complex levels were 1.4 +/- 0.3 (mean +/- SD) and 0.8 +/- 0.1 microgram/mL after 1 hour of infusion. At the higher APC dose, the APC-PCI level was similar to the APC-alpha 1AT level during the first 30 minutes, but after 1 hour of infusion the APC-alpha 1AT level was higher than the APC-PCI level, reaching 4.1 +/- 1.2 and 2.9 +/- 1.2 microgram/mL, respectively. After 24 hours, complex levels had returned to basal conditions. During infusion of protein C (1.0 mg/kg in 1 hour), both complexes were detected in low concentrations. Following bolus injection of APC, half-lives (t1/2) for APC and APC-PCI and APC-alpha 1AT complexes of 10, 40, and 140 minutes, respectively, were observed. After 1-hour incubation with 2.5 micrograms/mL APC, baboon plasma contained 1.0 +/- 0.2 and 0.8 +/- 0.1 microgram/mL of APC-PCI and APC-alpha 1AT, respectively. Addition of 10 micrograms/mL APC to baboon plasma yielded 2.5 and 2.4 micrograms/mL APC-PCI and APC-alpha 1AT after 1 hour, respectively. Immunoblotting analysis also showed in vivo formation of complexes of APC with an auxilliary inhibitor but not in vitro in citrated plasma. These data show that both PCI and alpha 1AT are physiologic inhibitors of APC and suggest that when PCI is depleted by a high dose of APC, alpha 1AT becomes the major inhibitor of APC.
Grating Visual Acuity in Eyes With Retinal Residua of Retinopathy of Prematurity (1995)

Acute-phase retinopathy of prematurity that regresses without retinal residua produces no deficit in grating visual acuity between 1 and 4 1/2 years of age. In contrast, eyes with macular heterotopia show a visual acuity deficit, and the deficit is greater at older than at younger ages. Eyes with retinal fold or partial detachment that have measurable visual acuity show large visual acuity deficits at all ages.
Modulation of mechanical properties in multiple-component tissue adhesives (2000)

In vitro, ex vivo, and in vivo studies were performed to investigate the effect of mixing upon the mechanical properties of a two-component tissue adhesive. The hypothesis investigated was that a more complete mixing of the two components would yield an increase in the mechanical performance of the adhesive. This in turn would be demonstrated by improved outcomes in models of clinical sealant application. In vitro stereological analysis of tissue adhesive mixed and delivered by several different applicators demonstrated variation in the amount of mixing provided by each type of delivery system. Ex vivo tensile adhesive strength showed that there was a correlation between the amount of mixing and bonding strength; that is, more thorough mixing demonstrated higher adhesive strength. No significant difference was seen, however, between the different applicator types and impact on in vivo dermal incisional closure strength. There was a correlation, though, in amount of mixing and in vivo hemostasis. In a rabbit spleen incision model, a more thoroughly mixed sealant corresponded with a decrease in time to obtain complete hemostasis, as well as less sealant used. The effects of mixing on tissue-adhesive mechanical performance were influenced somewhat by the amount of mixing provided by the applicator. This effect, however, was dependent upon the sealant formulation and the type of in vivo application.
Influence of multiple internal reflections and thermal expansion on the effective diffraction efficiency of holograms stored in lithium niobate (1975)

In experimentally determining the diffraction efficiency of holograms stored in lithium niobate and similar materials by exposure to known amounts of light, it is necessary to take into account multiple internal reflections from the surfaces. In particular, the effective diffraction efficiency is very sensitive to small changes in temperature (∼ 1 °C) such as those which are easily produced by exposure to medium−intensity laser beams.
Improved dialysis method for free thyroxin in serum compared with five commercial radioimmunoassays in nonthyroidal illness and subjects with abnormal concentrations of thyroxin-binding globulin. (1983)

We describe a method for free thyroxin (FT4) in serum, based on radioimmunoassay of T4 in serum dialysate, FT4(D). The method is analytically accurate, sensitive, reproducible, and suitable for routine use in the clinical laboratory. We compared results by this method with those obtained with five commercial FT4 assays (Amerlex, GammaCoat, ImmoPhase, LiquiSol, Spiria) and the free T4 index (FT4I). In several of the patients with nonthyroidal illness FT4(D) was above normal and FT4 as measured with the commercial assays was subnormal. In the third trimester of pregnancy all the FT4 methods gave decreased mean values, though the decreases were of various magnitudes: FT4(D) 32%, Amerlex 44%, GammaCoat 40%, Spiria 19%, LiquiSol 16%, and ImmoPhase 13%, respectively. FT4I was significantly higher than normal during late pregnancy. In women taking oral contraceptives the mean FT4I was increased, but there was no significant effect on the results obtained with the various FT4 methods. All subjects with hereditarily high or low serum thyroxin-binding globulin had normal FT4(D) and abnormal FT4I. Amerlex, ImmoPhase, and LiquiSol misclassified some of the subjects with hereditarily abnormal thyroxin-binding globulin.
ND voxel localization using large-scale 3D environmental map and RGB-D camera (2013)

We propose an efficient 3D global localization and tracking technique for a mobile robot in a large-scale environment using 3D geometrical map and a RGB-D camera. With the rapid development of high-resolution 3D range sensors, high-speed processing of a large amount of 3D data is becoming an urgent challenge in robotic applications such as localization. To tackle this problem, the proposed technique utilizes a ND (Normal Distributions) voxel representation. Firstly, a 3D geometrical map represented by point-clouds is converted to a number of ND voxels, and local features are extracted and stored as an environmental map. In addition, range data captured by a RGB-D camera is also converted to the ND voxels, and local features are calculated. For global localization and tracking, the similarity of ND voxels between the environmental map and the sensory data is examined according to the local features or Kullback-Leibler divergence, and optimum positions are determined in a framework of a particle filter. Experimental results show that the proposed technique is robust for the similarity in a 3D environmental map and converges more stable than a standard voxel-based scan matching technique.
تأثير زاوية ونصف قطر الحز على معامل حساسية الحز للصلب المتوسط الكربون تحت تأثير الاجهادات الاستاتيكية والديناميكية (2012)

تعتبر ممركزات الإجهاد حرجة لمعظم أجزاء المقاطع الهندسية ،حيث ان معظم حالات الفشل تعود الى تلك الظاهرة . يتناول هذا البحث دراسة تأثير كل من زواية ونصف قطر جذر الحز على معامل حساسية الحز للصلب المتوسط الكربون تحت تأثير اختبارات الشد وكلال الانحناء لعينات دائرية المقطع . أوضحت نتائج البحث ان زيادة زاوية ونصف قطر جذر الحز تؤدي الى زيادة في حدود مقاومة الشد ، وبالتالي فأن تأثير تركيز الإجهاد يقل مع زيادة زاوية ونصف قطر جذر الحز . حساسية الحز تكون متغيرة ما يبن معامل تركيز الإجهاد النظري (Kt) الإجهاد الإنهياري (Kf) ، حيث وجد ان معامل تركيز الإجهاد ألانهياري (Kf) يكون اقل من معامل تركيز الإجهاد النظري (Kt).
Conformational Polymorphism (2013)

An unambiguous definition of conformational change and conformational polymorphism, as well as a quantitative basis for the likelihood of its appearance, is reviewed. Conformational adjustment and conformational change are different phenomena. Two polymorphs are conformational polymorphs only if their conformations are related by conformational change. Conformational change requires a change of gas-phase conformer and, hence, crossing of an energy barrier. Energy differences associated with conformational variations of small organic molecules in different polymorphs are usually small. Higher-energy conformations in crystals are rare but possible for molecules that are able to break an intramolecular interaction in favor of a strong intermolecular interaction and molecules that crystallize in special symmetry positions. Polymorphic molecules containing R-bonds that are prone to both change and adjust are likely to display a rich polymorphic landscape.
Improved Stainless Steel Needle Valve (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImproved Stainless Steel Needle ValveA. R. Glasgow and G. S. Ross, Sr.Cite this: Anal. Chem. 1954, 26, 12, 2003Publication Date (Print):December 1, 1954Publication History Published online1 May 2002Published inissue 1 December 1954https://pubs.acs.org/doi/10.1021/ac60096a053https://doi.org/10.1021/ac60096a053research-articleACS PublicationsRequest reuse permissionsArticle Views28Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<title>Scanner-based image quality measurement system for automated analysis of EP output</title> (2003)

Inspection of electrophotographic print cartridge quality and compatibility requires analysis of hundreds of pages on a wide population of printers and copiers. Although print quality inspection is often achieved through the use of anchor prints and densitometry, more comprehensive analysis and quantitative data is desired for performance tracking, benchmarking and failure mode analysis. Image quality measurement systems range in price and performance, image capture paths and levels of automation. In order to address the requirements of a specific application, careful consideration was made to print volume, budgetary limits, and the scope of the desired image quality measurements. A flatbed scanner-based image quality measurement system was selected to support high throughput, maximal automation, and sufficient flexibility for both measurement methods and image sampling rates. Using an automatic document feeder (ADF) for sample management, a half ream of prints can be measured automatically without operator intervention. The system includes optical character recognition (OCR) for automatic determination of target type for measurement suite selection. This capability also enables measurement of mixed stacks of targets since each sample is identified prior to measurement. In addition, OCR is used to read toner ID, machine ID, print count, and other pertinent information regarding the printing conditions and environment. This data is saved to a data file along with the measurement results for complete test documentation. Measurement methods were developed to replace current methods of visual inspection and densitometry. The features that were being analyzed visually could be addressed via standard measurement algorithms. Measurement of density proved to be less simple since the scanner is not a densitometer and anything short of an excellent estimation would be meaningless. In order to address the measurement of density, a transfer curve was built to translate the gray scale values that are the fundamental scanner output into an estimation of density. The correlation coefficient was excellent and was deemed to be adequate for this application. This paper addresses the automation process, image analysis and data management required by this application.
Salvage of Tissue Expander in the Setting of Mastectomy Flap Necrosis: A 13-Year Experience Using Timed Excision with Continued Expansion (2009)

Timed excision with continued expansion is a straightforward procedure associated with a low incidence of failure. This approach allows for salvage of a significant percentage of threatened tissue expanders and may be coordinated with adjuvant oncologic therapy without excessive delays.
Peripheral arterial vasodilation hypothesis: A proposal for the initiation of renal sodium and water retention in cirrhosis (1988)

Renal sodium and water retention and plasma volume expansion have been shown to precede ascites formation in experimental cirrhosis. The classical "underfilling" theory, in which ascites formation causes hypovolemia and initiates secondary renal sodium and water retention, thus seems unlikely. While the occurrence of primary renal sodium and water retention and plasma volume expansion prior to ascites formation favors the "overflow" hypothesis, the stimulation of the renin-angiotensin-aldosterone system, vasopressin release and sympathetic nervous system associated with cirrhosis is not consonant with primary volume expansion. In this present article, the "Peripheral Arterial Vasodilation Hypothesis" is proposed as the initiator of sodium and water retention in cirrhosis. Peripheral arterial vasodilation is one of the earliest observations in the cirrhotic patient and experimental animals with cirrhosis. Arterial vasodilators and arteriovenous fistula are other examples in which renal sodium and water retention occur secondary to a decreased filling of the arterial vascular tree. An increase in cardiac output and hormonal stimulation are common features of cirrhosis, arteriovenous fistula and drug-induced peripheral arterial vasodilation. However, a predilection for the retained sodium and water to transudate into the abdominal cavity occurs with cirrhosis because of the presence of portal hypertension. The Peripheral Arterial Vasodilation Hypothesis also explains the continuum from compensated to decompensated cirrhosis to the hepatorenal syndrome.
Aluminium <i>per se</i> and in the anti‐acid drug sucralfate promotes sensitization via the oral route (2009)

Our data show for the first time that ALUM acts as a Th2-adjuvant via the oral route. This suggests that orally applied SUC leads to an enhanced risk for food allergy, not only by inhibiting peptic digestion but also by acting as a Th2-adjuvant by its ALUM content.