gebhart/patrepeval huggingface dataset:
Effects of glucagon-like peptide-1(7–36)amide on motility and sensation of the proximal stomach in humans (2002)

GLP-1 is a candidate physiological inhibitory regulator of fundus motility. It allows the stomach to afford a larger volume without increase in sensation.
Frequency-modulated multimode laser diode for fiber Bragg grating sensors (1998)

A demodulation scheme for fiber Bragg grating (FBG) sensors is presented. It is based on the generation of an electrical carrier by using a modulated multimode laser diode to illuminate the fiber grating. The change in Bragg wavelength is measured by tracking the phase of the carrier at the detector output in either an open- or a closed-loop scheme. A theoretical analysis of the interrogation technique in terms of linearity and dynamic range is presented. Experimental data were obtained for both strain and temperature measurements. Sensitivities of 0.7 /spl mu//spl epsiv///spl radic/Hz and 0.05/spl deg/C//spl radic/Hz were obtained over a dynamic range of /spl ap/60 dB. The application of this demodulation scheme to a multiplexed sensing system is also demonstrated.
Are You Tampering With My Data? (2018)

We propose a novel approach towards adversarial attacks on neural networks (NN), focusing on tampering the data used for training instead of generating attacks on trained models. Our network-agnostic method creates a backdoor during training which can be exploited at test time to force a neural network to exhibit abnormal behaviour. We demonstrate on two widely used datasets (CIFAR-10 and SVHN) that a universal modification of just one pixel per image for all the images of a class in the training set is enough to corrupt the training procedure of several state-of-the-art deep neural networks causing the networks to misclassify any images to which the modification is applied. Our aim is to bring to the attention of the machine learning community, the possibility that even learning-based methods that are personally trained on public datasets can be subject to attacks by a skillful adversary.
Evaluation of diameter protocol against IPFIX requirements (2001)

This document provides an evaluation of the applicability of the Diameter protocol [DIAMETER] as an IPFIX protocol. It compares the properties and capabilities of the Diameter protocol to the IPFIX requirements [IPFIX-REQ].
Wholesale price list : February 15 1932 / (1932)

We maintain a full line at Berkeley, Modesto, Fresno and Sacramento, which enables us to give you prompt service from our nearest warehouse This old PIONEER alfalfa plant was taken from a field of PIONEER Chilean alfalfa just before cut¬ ting' for seed.This field was seeded in 1884 and is now 46 years old.and is still yielding excellent crops of dairy hay and a crop of PIONEER Chilean alfalfa seed each year.
Research and Development for Inertial Energy Storage Based on a Flexible Flywheel. (1980)

Abstract : A design concept for a nonrigid energy storage flywheel suitable for home or farm use has been investigated. The distinguishing feature of this flexible flywheel is its construction from high strength fibers (such as synthetic rope) with no bonding agent. The work done to date indicates that the flexible flywheel is self balancing, safe, has a high energy density capability (60 Wh/lb), and should be simple and economical to manufacture. The major thrust of the contract work has been to find a solution to the subsynchronous whirling instability, a problem common to all high speed flywheels, which is especially severe in the flexible flywheel due to the high supercritical speed ratio and the large amount of internal friction. A unique gimbal support system has been designed and analyzed and tested on this contract which stabilizes the flywheel without the need for a squeeze film damper. The conceptual design was developed for a flexible flywheel energy storage system suitable for interfacing with a small scale solar energy source. Cost estimates were prepared for the system in the 10 KWh and 50 KWh sizes.
Biochemical Characterization of Secreted Proteases During Growth in <i>Tetrahymena pyriformis</i> WH‐14: Comparison of Extracellular with Intracellular Proteases (1982)

Tetrahymena pyriformis strain WH-14 secreted large quantities of intracellular proteases into its culture medium during growth. Extracellular enzymes were purified to homogeneity from cell-free medium by ammonium sulfate precipitation, CM-Sephadex column chromatography, gel filtration, and DEAE-cellulose column chromatography. The DEAE-cellulose eluates were separated into four peaks (P-I, P-II, P-III, and P-IV), each of which exhibited a different specific activity toward azocasein and alpha-N-benzoyl-DL-arginine-rho-nitroanilide (Bz-Arg-Nan). These four forms of the protease showed similarity in amino acid composition, molecular weight (21,000-24,000), and antigenic reactivity. They had pH optima at neutral range. P-I showed the highest specificity to azocasein whereas P-IV was most effective toward the synthetic substrates. The Km values for hydrolysis of Bz-Arg-Nan were 2.4, 1.6, 1.3 and 1.4 mM for P-I, P-II, P-III, and P-IV, respectively, and the corresponding Kcat/Km values were 5.0, 9.4, 28.5, and 114.3 S-1 . M-1. These properties of secreted proteases were compared with those of intracellular proteases purified by the same procedure except for the initial Triton X-100 extraction. There were similarities in specific activity toward two substrates, molecular weight, Km, pH optima, and antigenic reactivity between the proteases from two sources, providing evidence that the intracellular proteases may be secreted into the extracellular medium without modification.
Mazda 4-Rotor Rotary Engine for the Le Mans 24-Hour Endurance Race (1992)

<div class="htmlview paragraph">The “R26B” 4-rotor rotary engine is a powerplant that brought a Mazda racing car to victory in the 1991 Le Mans 24-hour endurance race. This engine was developed to achieve high levels of power output, fuel efficiency, and reliability, as required of endurance racing engines. This paper describes the basic structure of the engine, including a 3-piece eccentric shaft that represents a major technological achievement incorporated in the engine, as well as other technological innovations employed for the enhancement of the engine's power output and reliability, and for reducing its fuel consumption. These innovations include a telescopic intake manifold system, peripheral port injection, 3-plug ignition system, 2-piece ceramic apex seal, and a cermet coating on the rubbed surfaces of the housings.</div>
A comparative analysis between skilled nursing facilities experiencing high versus low resident transfer injury rates (2010)

Nonossifying fibromas and fibrous cortical defects are the most common benign lesions of the skeletal system. They are frequently detected incidentally on radiographs taken for an unrelated reason. The diagnosis is routinely made solely on the basis of the history, physical examination, and radiographic appearance. The incidence of multifocal nonossifying fibroma is typically underestimated in patients initially found to have a solitary lesion; the use of a limited skeletal survey rather than bone scan may help detect multifocal lesions in this population. Small, asymptomatic lesions may be followed over time using serial radiographs. Incisional biopsy, curettage, and bone grafting are indicated for large lesions that raise concern for impending pathologic fracture, for lesions that have become painful, and for lesions whose characteristics prevent a definitive radiographic diagnosis. Pathologic fractures involving these lesions should be treated with cast immobilization until the fracture has healed, followed by biopsy, curettage, and bone grafting.
Expression of the RNA‐binding protein Musashi1 in adult liver stem‐like cells (2010)

These findings demonstrate that the RNA-binding protein Musashi1 is expressed with Notch signaling markers in adult liver stem-like cells.
Design of double-sampling /spl Sigma//spl Delta/ modulation A/D converters with bilinear integrators (2005)

Double-sampling techniques allow to double the sampling frequency of a switched capacitor /spl Sigma//spl Delta/ analog-to-digital convertors without increasing the clock frequency. Unfortunately, path mismatch between the double sampling branches may cause noise folding, which could ruin the modulator's performance. The fully floating double-sampling integrator is an interesting building block to be used in such a double sampling /spl Sigma//spl Delta/ modulator because its operation is tolerant to path mismatch. However, this circuit exhibits an undesired bilinear filter effect. This effectively increases the order of the modulator by one. Due to this, previously presented structures don't have enough freedom to fully control the modulator pole positions. In this paper, we introduce modified topologies for double-sampling /spl Sigma//spl Delta/ modulators built with bilinear integrators. We show that these architectures provide full control of the modulator pole positions and hence can be used to implement any noise transfer function. Additionally, analytical expressions are obtained for the residual folded noise.
Differential localization of human nongastric H<sup>+</sup>-K<sup>+</sup>-ATPase ATP1AL1 in polarized renal epithelial cells (2000)

The human H(+)-K(+)-ATPase, ATP1AL1, belongs to the subgroup of nongastric, K(+)-transporting ATPases. In concert with the structurally related gastric H(+)-K(+)-ATPase, it plays a major role in K(+) reabsorption in various tissues, including colon and kidney. Physiological and immunocytochemical data suggest that the functional heteromeric ion pumps are usually found in the apical plasma membranes of renal epithelial cells. However, the low expression levels of characteristic nongastric ion pumps makes it difficult to verify their spatial distribution in vivo. To investigate the sorting behavior of ATP1AL1, we expressed this pump by stable transfection in MDCK and LLC-PK(1) renal epithelial cell lines. Stable interaction of ATP1AL1 with either the endogenous Na(+)-K(+)-ATPase beta-subunit or the gastric H(+)-K(+)-ATPase beta-subunit was tested by confocal immunofluorescence microscopy and surface biotinylation. In cells transfected with ATP1AL1 alone, the alpha-subunit accumulated intracellularly, consistent with its inability to assemble and travel to the plasma membrane with the endogenous Na(+)-K(+)-ATPase beta-subunit. Cotransfection of ATP1AL1 with the gastric H(+)-K(+)-ATPase beta-subunit resulted in plasma membrane localization of both pump subunits. In cotransfected MDCK cells the heteromeric ion pump was predominantly polarized to the apical plasma membrane. Functional expression of ATP1AL1 was confirmed by (86)Rb(+) uptake measurements. In contrast, cotransfected LLC-PK(1) cells accumulate ATP1AL1 at the lateral membrane. The distinct polarization of ATP1AL1 indicates that the alpha-subunit encodes sorting information that is differently interpreted by cell type-specific sorting mechanisms.
Tribological study of non-asbestos fiber reinforced phenolic composites for braking applications (1994)

A cashew modified phenolic resin was used as the binder to prepare several different nonasbestos fiber reinforced composite friction materials. Friction-wear tests were conducted at various loads, speeds and temperatures on a Chase friction testing machine. The fade and wear characteristics of glass and carbon fiber reinforced friction materials were studied. The wear rates of hybrid composites containing Kevlar{reg_sign} (registered trademark of E.I. duPont de Nemours) pulp were compared to those of control composites without Kevlar{reg_sign} pulp.
Electrophysiological evidence for a gradient of G protein‐gated K<sup>+</sup> current in adult mouse atria (2003)

Whole cell current and voltage clamp techniques were used to examine the properties of acetylcholine-sensitive K+ current (IKACh) in myocytes from adult mouse atrium. Superfusion of a maximal dose of carbachol (CCh; 10 microM) caused a substantial increase in K+ current in all myocytes examined. The current-voltage (I-V) relation of maximally activated IKACh exhibited weak inward rectification. Consequently, CCh increased the amount of depolarising current necessary to evoke action potentials (APs), and APs evoked in CCh had significantly shorter durations than control APs (P<0.05). The effects of CCh on K+ current and on AP properties were blocked by the muscarinic receptor antagonist methoctramine (1 microM). ACh (10 microM) activated a K+ current with identical properties to that activated by CCh, as did the A1 receptor agonist adenosine (100 microM). Right atrial myocytes had significantly more IKACh than left atrial myocytes (P<0.05), regardless of whether IKACh was evoked by superfusion of muscarinic or A1 receptor agonists. IKACh current density was significantly higher in SA node myocytes than either right or left atrial myocytes. These data identify a gradient of IKACh current density across the supraventricular structures of mouse heart. This gradient, combined with the heterogeneous distribution of parasympathetic innervation of the atria, may contribute to the proarrhythmic ability of vagal nerve stimulation to augment dispersion of atrial refractoriness.
Synthesis and Microarray-Assisted Binding Studies of Core Xylose and Fucose Containing N-Glycans (2015)

The synthesis of a collection of 33 xylosylated and core-fucosylated N-glycans found only in nonmammalian organisms such as plants and parasitic helminths has been achieved by employing a highly convergent chemo-enzymatic approach. The influence of these core modifications on the interaction with plant lectins, with the human lectin DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Nonintegrin), and with serum antibodies from schistosome-infected individuals was studied. Core xylosylation markedly reduced or completely abolished binding to several mannose-binding plant lectins and to DC-SIGN, a C-type lectin receptor present on antigen presenting cells. Employing the synthetic collection of core-fucosylated and core-xylosylated N-glycans in the context of a larger glycan array including structures lacking these core modifications, we were able to dissect core xylose and core fucose specific antiglycan antibody responses in S. mansoni infection sera, and we observed clear and immunologically relevant differences between children and adult groups infected with this parasite. The work presented here suggests that, quite similar to bisecting N-acetylglucosamine, core xylose distorts the conformation of the unsubstituted glycan, with important implications for the immunogenicity and protein binding properties of complex N-glycans.
ac driving amplitude dependent systematic error in scanning Kelvin probe microscope measurements: Detection and correction (2006)

The dependence of the contact potential difference (CPD) reading on the ac driving amplitude in scanning Kelvin probe microscope (SKPM) hinders researchers from quantifying true material properties. We show theoretically and demonstrate experimentally that an ac driving amplitude dependence in the SKPM measurement can come from a systematic error, and it is common for all tip sample systems as long as there is a nonzero tracking error in the feedback control loop of the instrument. We further propose a methodology to detect and to correct the ac driving amplitude dependent systematic error in SKPM measurements. The true contact potential difference can be found by applying a linear regression to the measured CPD versus one over ac driving amplitude data. Two scenarios are studied: (a) when the surface being scanned by SKPM is not semiconducting and there is an ac driving amplitude dependent systematic error; (b) when a semiconductor surface is probed and asymmetric band bending occurs when the systematic error is present. Experiments are conducted using a commercial SKPM and CPD measurement results of two systems: platinum-iridium∕gap∕gold and platinum-iridium∕gap∕thermal oxide∕silicon are discussed.
Lines of Constant Correlated Color Temperature Based on MacAdam’s (u,υ) Uniform Chromaticity Transformation of the CIE Diagram (1963)

The chromaticities of hot bodies (such as the filaments of incandescent lamps) and the various phases of daylight are often expressed on the color–temperature scale. Such chromaticities do not usually coincide precisely with those of the blackbody at any temperature, but are specified by giving the temperature of the blackbody yielding the nearest chromaticity match. Thus each chromaticity point near the Planckian locus is correlated with a chromaticity point on it, and the color temperature corresponding to the Planckian chromaticity is called the correlated color temperature. If the decision as to the nearest Planckian chromaticity is based on a uniform-chromaticity-scale (UCS) diagram, the chromaticity points correlated with each Planckian chromaticity fall on a straight line (isotemperature line) on the chromaticity diagram normal to the Planckian locus at that Planckian chromaticity. The UCS diagram proposed by MacAdam in 1937 and recommended in 1959 by the International Commission on Illumination (CIE) has been used here to define the isotemperature lines. Graphs showing the Planckian locus and the isotemperature lines both in the CIE (x,y)-diagram and in the MacAdam CIE (u,υ)-diagram are shown at every 10 microreciprocal degrees for all color temperatures higher than 1515°K.
Body Cell Mass in Cancer‐Bearing and Anorexic Patients (1987)

We used a sensitive whole body counter which measures potassium-40 (40K) to determine total body potassium and to estimate body cell mass (BCM) in 104 previously untreated patients with upper gastrointestinal malignancies, 233 normal volunteers, and 18 patients with anorexia nervosa. BCM was greater in normal males than in females. In both normal males and females, the BCM tended to decrease with age, both as an absolute measure and as a percentage of body weight. Anorexia nervosa patients experienced marked weight loss (30.5%), and had significant depletion of absolute BCM, but exhibited relative sparing of BCM as indicated by a rise in BCM as a percentage of body weight. This may reflect a normal adaptation and predominant fat utilization in chronic malnutrition. The cancer patients, on the other hand, had significant weight loss (12.7% for females, 13.9% for males) and demonstrated a proportional decline in BCM, with no change in BCM as a percentage of body weight. These findings support the contention that, in the cancer-bearing patient, weight loss consists of a significant depletion of both fat and BCM. The challenge to the clinicians caring for cancer patients is repletion of this supremely functional body compartment.
Statistical multiplexing with loss priorities in rate-based congestion control of high-speed networks (1994)

Statistical multiplexing with loss priorities is a central element in ATM-based B-ISDN. Cell priorities arise from the marking schemes employed by the access regulators to identify excess cells, which are dropped during periods of congestion, Also, in real time applications, such as hierarchically coded voice and video, cells are assigned priorities which correspond to their importance to service quality, so that when congestion occurs only the least important are dropped. The authors present a stochastic fluid model of statistical multiplexing with loss priorities. Each Markov modulated fluid source generates streams of different priorities. The burstiness of each stream and the correlation between the priority streams are captured in the mode. The loss priority is implemented by selectively discarding cells of certain priority classes when the buffer content exceeds a corresponding threshold. To handle high dimensional source models, the authors develop an algebraic theory for the efficient computation of the spectrum of the statistical multiplexing system, which generalizes previous results for on-off sources. It is shown that to obtain the solution of the statistical multiplexing problem with J priority classes, J different 1-class problems need to be solved, together with a system of linear equations which describe the behavior of the stationary distribution at the thresholds. The numerical results demonstrate the manner in which i) the threshold level controls the tradeoff between delay of higher priority cells and the loss probability of lower priority cells, and ii) the buffer size controls the loss probability of higher priority cells.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Technological Overview of iPS Induction from Human Adult Somatic Cells (2013)

The unlimited proliferation capacity of embryonic stem cells (ESCs) combined with their pluripotent differentiation potential in various lineages raised great interest in both the scientific community and the public at large with hope for future prospects of regenerative medicine. However, since ESCs are derived from human embryos, their use is associated with significant ethical issues preventing broad studies and therapeutic applications. To get around this bottleneck, Takahashi and Yamanaka have recently achieved the conversion of adult somatic cells into ES-like cells via the forced expression of four transcription factors: Oct3/4, Sox2, Klf4 and c-Myc. This first demonstration attracted public attention and opened a new field of stem cells research with both cognitive - such as disease modeling - and therapeutic prospects. This pioneer work just received the 2012 Nobel Prize in Physiology or Medicine. Many methods have been reported since 2006, for the generation of induced pluripotent stem (iPS) cells. Most strategies currently under use are based on gene delivery via gamma-retroviral or lentiviral vectors; some experiments have also been successful using plasmids or transposons- based systems and few with adenovirus. However, most experiments involve integration in the host cell genome with an identified risk for insertional mutagenesis and oncogenic transformation. To circumvent such risks which are deemed incompatible with therapeutic prospects, significant progress has been made with transgene-free reprogramming methods based on e.g.: sendai virus or direct mRNA or protein delivery to achieve conversion of adult cells into iPS. In this review we aim to cover current knowledge relating to both delivery systems and combinations of inducing factors including chemicals which are used to generate human iPS cells. Finally, genetic instability resulting from the reprogramming process is also being considered as a safety bottleneck for future clinical translation and stem cell-therapy prospects based on iPS.
Methods and Tactics in Cognitive Science (2014)

First published in 1984. The editors of this volume are three psychologists whose work has brought them into frequent contact with other disciplines within cognitive science, particularly linguistics and artificial intelligence. Cognitive science is based on the belief that crossing the boundaries of the traditional disciplines is not merely possible, but indeed essential in the study of cognition. The purpose of this volume is to facilitate this interaction among the disciplines that constitute cognitive science, and trying to do this not by an abstract discussion of methodological issues, but by concrete example.