gebhart/patrepeval huggingface dataset:
<sc>Replisom</sc>: Disciplined Tiny Memory Replication for Massive IoT Devices in LTE Edge Cloud (2015)

Augmenting the long-term evolution (LTE)-evolved NodeB (eNB) with cloud resources offers a low-latency, resilient, and LTE-aware environment for offloading the Internet of Things (IoT) services and applications. By means of devices memory replication, the IoT applications deployed at an LTE-integrated edge cloud can scale its computing and storage requirements to support different resource-intensive service offerings. Despite this potential, the massive number of IoT devices limits the LTE edge cloud responsiveness as the LTE radio interface becomes the major bottleneck given the unscalability of its uplink access and data transfer procedures to support a large number of devices that simultaneously replicate their memory objects with the LTE edge cloud. We propose Replisom; an LTE-aware edge cloud architecture and an LTE-optimized memory replication protocol which relaxes the LTE bottlenecks by a delay and radio resource-efficient memory replication protocol based on the device-to-device communication technology and the sparse recovery in the theory of compressed sampling. Replisom effectively schedules the memory replication occasions to resolve contentions for the radio resources as a large number of devices simultaneously transmit their memory replicas. Our analysis and numerical evaluation suggest that this system has significant potential in reducing the delay, energy consumption, and cost for cloud offloading of IoT applications given the massive number of devices with tiny memory sizes.
Identification of the Strong Vasorelaxing Substance Scirpusin B, a Dimer of Piceatannol, from Passion Fruit (<i>Passiflora edulis</i>) Seeds (2011)

Piceatannol is present in passion fruit (Passiflora edulis) seeds in high amounts. In this study, we isolated the second major polyphenolic compound of passion fruit seeds and identified it as scirpusin B, which is a dimer of piceatannol. We investigated the antioxidant activities and vasorelaxing effects of these polyphenols. Their antioxidant effects were measured using an in vitro 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, and their vasorelaxant effects were determined ex vivo in rat thoracic aorta. Both polyphenolic compounds exhibited potent antioxidant activities and significant vasorelaxant effects in endothelium-intact aortas. More specifically, scirpusin B exerted a greater antioxidant activity and vasorelaxant effect compared with that of piceatannol. Additionally, the vasorelaxation effects of the compounds were induced via the NO derived from the endothelium. This study provides the possibility that polyphenols in passion fruit seeds are effective against cardiovascular diseases (CVDs).
Gonadotropin-induced expression of pancreatitis-associated protein-III mRNA in the rat ovary at the time of ovulation (2002)

The ovulatory process in mammals involves gross physiological events in the ovary that cause transient deterioration of the ovarian connective tissue and rupture of the apical walls of mature follicles. This gonadotropin-induced process has features similar to an acute inflammatory reaction that affects most of the ovary. The present study reveals that the ovulatory events include induction of mRNA for pancreatitis-associated protein-III (PAP-III). Immature Wistar rats were primed with 10 IU equine chorionic gonadotropin s.c., and 48 h later the 12-h ovulatory process was initiated by 10 IU human chorionic gonadotropin (hCG) s.c. Ovarian RNA was extracted at 0, 2, 4, 8, 12 and 24 h after the animals were injected with hCG. The RNA extracts were used for RT-PCR differential display to detect PAP-III gene expression in the stimulated ovarian tissue. Northern blotting showed that transcription was significantly greater at 4-12 h after the ovaries had been stimulated by hCG. In situ hybridization indicated that PAP-III mRNA expression was limited mainly to the hilar region of the ovarian stroma, with most of the signal emanating from endothelial cells that lined the inner walls of blood vessels, and from small secondary follicles. Treatment of the animals with ovulation-blocking doses of indomethacin (an inhibitor of prostanoid synthesis) or epostane (an inhibitor of progesterone synthesis) revealed that ovarian transcription of PAP-III mRNA was moderately dependent on ovarian progesterone synthesis. In conclusion, the present evidence of an increase in PAP-III gene expression in gonadotropin-stimulated ovaries provides further evidence that the ovulatory process is comparable to an inflammatory reaction.
Purification and Identification of Secreted Oxidative Stress-induced Factors from Vascular Smooth Muscle Cells (2000)

Reactive oxygen species have been implicated in the pathogenesis of atherosclerosis and hypertension, in part by promoting vascular smooth muscle cell (VSMC) growth. We have previously shown that LY83583, a generator of O-(2), activated extracellular signal-regulated kinases (ERK1/2) with early (10 min) and late (2 h) peaks and stimulated VSMC growth. To investigate whether secreted oxidative stress-induced factors (termed SOXF) from VSMC were responsible for late ERK1/2 activation in response to LY83583, we purified putative SOXF proteins from conditioned medium (2 h of LY83583 exposure) by sequential chromatography based on activation of ERK1/2. Proteins identified by capillary chromatography, electrospray ionization tandem mass spectrometry, and data base searching included heat shock protein 90-alpha (HSP90-alpha) and cyclophilin B. Western blot analysis of conditioned medium showed specific secretion of HSP90-alpha but not HSP90-beta. Immunodepletion of HSP90-alpha from conditioned medium significantly inhibited conditioned medium-induced ERK1/2 activation. Human recombinant HSP90-alpha reproduced the effect of conditioned medium on ERK1/2 activation. These results show that brief oxidative stress causes sustained release of protein factors from VSMC that can stimulate ERK1/2. These factors may be important mediators for the effects of reactive oxygen species on vascular function.
Use of a polyvalent bacterial lysate in patients with recurrent respiratory tract infections: results of a prospective, placebo-controlled, randomized, double-blind study. (1999)

Respiratory tract infections (RTIs) are the most common infections in humans, and it is difficult to effectively treat patients with increased susceptibility to these ailments. LW 50020 (Luivac; Paspat oral), an oral immunomodulator consisting of the antigens of seven bacteria commonly involved in RTIs, has been developed for the induction of specific and nonspecific immune responses of the mucosa-associated lymphoid tissue. In this placebo-controlled study, the efficacy and safety of the tablet formulation of LW 50020 were evaluated in children and adults with recurrent RTIs. Tablets were taken once daily during two periods of 4 weeks each, interrupted by a treatment-free interval of 4 weeks. The main endpoint of the study, a clinical severity score that evaluated treatment benefits, was significantly lower in the second study period in patients treated with the bacterial lysate compared to patients given placebo. A comparison of the infection rates in the first and second study periods of patients treated with LW 50020 revealed a placebo-corrected reduction of 39% in children and a placebo-corrected reduction of 44% in adolescents and adults. The placebo-corrected duration of infections was shortened by 47% in children and by 55% in older patients. No serious drug-related side effects occurred. This study demonstrated that the oral bacterial immunomodulator LW 50020 is efficacious in treating patients with recurrent RTIs.
Structures of Gold Thin Films Formed by Ion Plating (1974)

Structures of gold particles in the initial stage prepared by d.c. and r.f. ion plating have been studied. The gold thin films were deposited onto the cleaved surfaces of rocksalt with ion plating and observed by an electron microscope. The results were summarized as follows. 1) As the density of ionized portion in the vapor beam was increased, most of gold particles were of rectangular form and characterized by the diffraction pattern of (001) orientation. 2) The epitaxial temperature was found to be lower than that in the ordinary vacuum deposition. 3) The r.f. method is superior to the d.c. method in forming thin film by ion plating.
Isolation of genomic and cDNA clones encoding bovine poly(A) binding protein II (1995)

cDNA clones for bovine poly(A) binding protein II (PAB II) were isolated. Their sequence predicts a protein of 32.8 kDa, revising earlier estimates of molecular mass. The protein contains one putative RNA-binding domain of the RNP type, an acidic N-terminal and a basic C-terminal domain. Analyses of authentic PAB II were in good agreement with all predictions from the cDNA sequence except that a number of arginine residues appeared to be post-translationally modified. Poly(A) binding protein II expressed in Escherichia coli was active in poly(A) binding and reconstitution of processive polyadenylation, including poly(A) tail length control. The cDNA clones showed a number of potential PAB II binding sites in the 3' untranslated sequence. Bovine poly(A)+RNA contained two mRNAs hybridizing to a PAB II-specific probe. Analysis of a genomic clone revealed six introns in the coding sequence. The revised molecular mass led to a demonstration of PAB II oligomer formation and a reinterpretation of earlier data concerning the protein's binding to poly(A).
Framework of AVS2-video coding (2013)

The first generation of Audio-video coding standard (AVS1) will become an international standard of IEEE (IEEE.1857). The second generation of Audio-video coding standard (AVS2) is a successor to IEEE.1857 which targets to higher coding efficiency, especially for high resolution videos, with reasonable complexity increase. Currently, AVS2 working draft is developed, in which symbolic techniques of IEEE.1857, such as logarithmic arithmetic coding, are still used. It also introduces new coding tools, e.g. flexible partition structure which is based on macro-block structure and high efficient prediction methods utilizing more texture information and temporal redundancies, etc. The performance of AVS2 is improved by 37% compared to the IEEE.1857 Jiaqiang Profile and 16.4% compared to H.264 in average. This paper provides an overview of the framework of AVS2-video coding standard.
Analysis of human papillomavirus types in exophytic condylomata acuminata by hybrid capture and Southern blot techniques (1993)

Exophytic condylomata acuminata of the external genitalia of 40 patients were analyzed for human papillomavirus (HPV) DNA by the Southern blot and hybrid capture methods. All lesions were initially analyzed by the Southern blot method by using a mixture of HPV type 6, 11, 16, and 18 whole genomic probes. Southern blots demonstrated characteristic PstI restriction patterns of HPV type 6, 11, or 16 in all but one lesion. HPV 6 subtypes accounted for 28 of 39 HPV-positive lesions. Twenty-seven of these 28 lesions contained HPV type 6a, and 1 lesion contained HPV type 6c. Eight lesions contained HPV type 11 and three contained HPV type 16. Two of the three condylomata acuminata containing HPV type 16 were obtained from solid-organ transplant recipients receiving immunosuppressive medications. The third lesion containing HPV type 16 was a typical exophytic condyloma acuminatum from a woman with previously resected vulvar carcinoma. The hybrid capture assay detected HPV DNAs in all lesions except the Southern blot-negative lesion. Twenty-five lesions were positive for the A probe only (HPV types 6 and 11 and related types). All of these lesions were found to contain HPV type 6 or 11 sequences in the Southern blot assay. The remaining 14 lesions were positive for both the A probe and the B probe (HPV types 16 and 18 and related types). The strongest signal in these 14 lesions by the hybrid capture assay was consistent with the result of the Southern blot assay in all but one case. We conclude that (i) HPV type 6a is the most common type found in these lesions, (ii) HPV type 16 may be present more often in exophytic condylomata acuminata from immunosuppressed individuals, (iii) hybrid capture is a useful tool for documenting the presence of HPV sequences in DNAs from exophytic condylomata acuminata, and (iv) in samples containing multiple HPV types, hybrid capture allows detection of minority HPV types.
GENOA—a customizable, front-end-retargetable source code analysis framework (1999)

Code analysis tools provide support for such software engineering tasks as program understanding, software metrics, testing, and reengineering. In this article we describe GENOA, the framework underlying application generators such as Aria and GEN++ which have been used to generate a wide range of practical code analysis tools. This experience illustrates front-end retargetability of GENOA; we describe the features of the GENOA framework that allow it to be used with different front ends. While permitting arbitrary parse tree computations, the GENOA specification language has special, compact iteration operators that are tuned for expressing simple, polynomial-time analysis programs; in fact, there is a useful sublanguage of the GENOA language that can express precisely all (and only) polynomial-time (PTIME) analysis programs on parse trees. Thus, we argue that the GENOA language is a simple and convenient vehicle for implementing a range of analysis tools. We also argue that the “front-and reuse” approach of GENOA offers an important advantage for tools aimed at large software projects: the reuse of complex, expensive build procedures to run generated tools over large source bases. In this article, we describe the GENOA framework and our experiences with it.
3D Printing Solutions for Microfluidic Chip-To-World Connections (2018)

The connection of microfluidic devices to the outer world by tubes and wires is an underestimated issue. We present methods based on 3D printing to realize microfluidic chip holders with reliable fluidic and electric connections. The chip holders are constructed by microstereolithography, an additive manufacturing technique with sub-millimeter resolution. The fluidic sealing between the chip and holder is achieved by placing O-rings, partly integrated into the 3D-printed structure. The electric connection of bonding pads located on microfluidic chips is realized by spring-probes fitted within the printed holder. Because there is no gluing or wire bonding necessary, it is easy to change the chip in the measurement setup. The spring probes and O-rings are aligned automatically because of their fixed position within the holder. In the case of bioanalysis applications such as cells, a limitation of 3D-printed objects is the leakage of cytotoxic residues from the printing material, cured resin. This was solved by coating the 3D-printed structures with parylene-C. The combination of silicon/glass microfluidic chips fabricated with highly-reliable clean-room technology and 3D-printed chip holders for the chip-to-world connection is a promising solution for applications where biocompatibility, optical transparency and accurate sample handling must be assured. 3D printing technology for such applications will eventually arise, enabling the fabrication of complete microfluidic devices.
A secured alternative path routing protocol against DoS attack (2014)

Wireless sensor networks are vulnerable to attacks as nodes are deployed in harsh environment depending on the application. We proposed A Secured Alternative path Routing Protocol against Dos Attack (SARP) method which prevents and detects the DoS attack in sensor network. The source node collects the data while sending the data to the sink the SARP uses alternative path to send the data these data need to secured in the transmitting region. Thus the sending node will calculate the trust value using the neighbor nodes report and the observed value. The neighbor report is collected from 2-Hop distance sensor node. The neighbor report is secured by using a secured session key.
Rapid adaptation using penalized-likelihood methods (2002)

We introduce rapid adaptation techniques that extend and improve two successful methods previously introduced, cluster weighting (CW) and MAPLR. First, we introduce an adaptation scheme called CWB which extends the cluster weighting adaptation method by including a bias term and a reference speaker model. CWB is shown to improve the adaptation performance as compared to CW. Second, we introduce an extension of cluster weighting that uses penalized-likelihood objective functions to stabilize the estimation and provide soft constraints. Third, we propose a variant of MAPLR adaptation that uses prior speaker information. Previously, prior distributions of transforms in MAPLR were obtained using the same adaptation data, speaker independent HMM means or by some heuristics. We propose to use the prior information of speaker variability to obtain the priors, by using CW or CWB weights. Penalized-likelihood or Bayesian theory serves as a tool to combine transformation based and prior speaker information based adaptation methods resulting in effective rapid adaptation techniques. The techniques are shown to outperform full, block diagonal and diagonal MLLR as well as some other recently proposed methods for rapid adaptation.
Association of elevated levels of cellular lipoteichoic acids of group B streptococci with human neonatal disease (1983)

Cell-associated lipoteichoic acids (LTAs) from late-exponential-phase cultures (serotypes Ia, Ib, Ic, II, and III) of group B streptococci isolated from infected and asymptomatically colonized infants were quantitated and characterized by growing the organisms in a chemically defined medium containing [3H]glycerol and [14C]acetate. Cell pellets were extracted with 45% aqueous phenol and chloroform-methanol and subjected to DEAE-Sephacel anion-exchange chromatography. Elution profiles resolved three major peaks, I, II, and III, with glycerol and phosphate present in a 1:1 molar ratio in each peak, and results obtained by Ouchterlony immunodiffusion analysis confirmed the presence of poly(glycerol phosphate). Saponification indicated that [14C]acetate was incorporated into fatty acids of peaks I and II only, suggesting that these were cell-associated LTAs. Peak II was of small molecular weight (less than 10,000) and probably represented another species of LTA. Peaks I and II were further demonstrated to be LTA by their ability to sensitize human type O erythrocytes. Peak III lacked fatty acids and was shown to probably be deacylated LTA. Quantitation of cell-associated teichoic acid material produced by the group B streptococcal strains indicated that the clinical isolates from infants with early- or late-onset disease possessed significantly higher levels than did the asymptomatic (clinical isolates from infants without symptoms of disease) group B streptococcal strains.
Fine-needle aspiration biopsy in diagnosis of soft tissue infections (1985)

This study explores the efficacy of fine-needle tissue aspiration biopsy in the diagnosis of soft tissue infections that cannot be sampled satisfactorily by regular microbiological techniques. Aspiration biopsy was performed on 50 patients with presumptive soft tissue infections. The conditions investigated were decubitus, diabetic, ischemic, venous, and traumatic ulcers (2, 6, 1, 2, and 7 patients, respectively), cellulitis (23 patients), chronic osteomyelitis (5 patients), and infected surgical wounds (4 patients). Where possible, comparison with superficial cultures was made. All of the cultures obtained from aspirate samples taken from ulcers, chronic osteomyelitis, and infected surgical wounds were positive. In cellulitis, cultures from aspirates were positive in 30 and 81% of the cases, respectively, depending on the presence or absence of concomitant antimicrobial therapy. These results suggest that fine-needle deep tissue aspiration biopsy is reliable and clinically applicable for deep tissue sample collection. The procedure is simple, brief, and does not cause significant discomfort to the patient. It also plays an important role in providing a guideline for antimicrobial therapy.
DG-AMMOS: A New tool to generate 3D conformation of small molecules using D istance G eometry and A utomated M olecular M echanics O ptimization for in silico S creening (2009)

DG-AMMOS provides fast, automated and reliable access to the generation of 3D conformation of small molecules and facilitates the preparation of a compound collection prior to high-throughput virtual screening computations. The validation of DG-AMMOS on several different datasets proves that generated structures are generally of equal quality or sometimes better than structures obtained by other tested methods.
The “Stinger” (2001)

American Journal of Physical Medicine & Rehabilitation: April 2001 - Volume 80 - Issue 4 - p 243
The present state of Kirkpatrick-Baez mirror systems at the ESRF (2002)

This paper describes the mechanical design of Kirkpatrick-Baez (KB) mirror systems that have been developed at the ESRF over several years. These very compact and stable though flexible focusing devices for synchrotron x-ray beams are based on bending an initially flat, superpolished plate, which permits to vary the focusing conditions. Nowadays a whole family of mechanical benders exists at the ESRF that allows us to choose the most adapted system according to the properties defined by the experiment such as the energy and energy range, the focusing parameters such as magnification and focusing distance and the substrate coatings, <i>i.e. </i>single-layer mirrors or multilayers. The geometrical characteristics of these KB systems can be chosen in terms of focal distances ranging from 0.1 to 3 m and circular or elliptical bending radii from 20 to 1000m. Mirror substrates such as silicon or pyrex, single-layer or multilayer coatings require different motorisations and deformation systems. The very challenging requirements for mechanical resolution and sensitivity have led to the development of several generations of micro-motors. The ESRF has built a special multi-purpose micropusher that provides the required resolution and linearity, a thrust up to 80 N and finally a good position latching. Issues such as mounting interfaces, stress in the bent mirror and the dynamic bender, local mirror deformation and curvature stability had to be addressed and were solved. The ESRF has developed mirror clamping technologies controlled by mechanical and optical metrologies. The dynamic stability and reproducibility requirements to achieve a spot size variable from sub-micron to tens of microns required by various beamlines necessitate a very high degree of stiffness.
How to Scope DMAIC Projects (2003)

IX SIGMA SUCCESS is supported by abundant training materials such as texts, videos and audio programs. These materials do an excellent job of telling the history of Six Sigma, providing case studies about extraordinary results at some organizations and explaining the Six Sigma DMAIC (define, measure, analyze, improve and control) process. The materials also cover some of the tools that need to be used and steps that must be taken during successful implementation of the Six Sigma DMAIC process. But there is little information about some necessary steps and tools. Many are not emphasized or not even addressed in Six Sigma training programs. As a result, those implementing Six Sigma have to rely heavily on learning through trial and error. One such step is the effective scoping of DMAIC projects. Scoping is a vital part of the define phase and can have a long-term impact on a Six Sigma program’s ultimate success.