gebhart/patrepeval huggingface dataset:
Prognosis for allergic fungal sinusitis (1997)

Allergic fungal sinusitis is a recently described clinical entity that has gained increased attention as a cause of chronic sinusitis. The diagnosis can be established by demonstrating (1) type I hypersensitivity confirmed by history, skin tests, or serology; (2) nasal polyposis; (3) characteristic CT scan; (4) eosinophilic mucus without fungal invasion into sinus tissue; and (5) positive fungal stain of sinus contents removed intraoperatively or during office endoscopy. The exact pathogenesis of allergic fungal sinusitis remains controversial, and no treatment modality has proved to be consistently effective. Several reports during the last decade have suggested that allergic fungal sinusitis recurs more frequently than chronic bacterial sinusitis, but no studies have specifically addressed the prognosis of allergic fungal sinusitis. During the past two and a half years, we have treated 26 patients with allergic fungal sinusitis. The treatment always included functional endoscopic sinus surgery, topical nasal steroids, postoperative nasal saline irrigations, and endoscopic cleaning in the office. Adjuvant medical therapy included systemic steroids, oral antifungals, a combination of systemic steroids and oral antifungals, or in some cases, no additional treatment. Outcome was graded subjectively as improved, unchanged, or worse. Mean follow-up was 14.5 months. Twenty-two of 26 patients were improved. In reviewing postoperative outcomes, we observed endoscopic recurrent disease that generally preceded patient symptoms. Consequently, we developed an endoscopic staging system to record postoperative clinical status. Use of this staging system allowed evaluation of various treatments and enabled classification of patient outcome. Nineteen of 24 patients examined with extensive follow-up had objective signs of recurrent disease. It appears that this is a chronic disease characterized by physical signs that appear before the return of subjective clinical symptoms.
The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation (2014)

Metabolic stress induces autophagy as an alternative source of energy and metabolites. Insufficient autophagy in nutrient-deprived cancer cells would be beneficial for cancer therapy. Here, we performed a functional screen in search of novel autophagy regulators from natural products. We showed that oblongifolin C (OC), a natural small molecule compound extracted from Garcinia yunnanensis Hu, is a potent autophagic flux inhibitor. Exposure to OC results in an increased number of autophagosomes and impaired degradation of SQSTM1/p62. Costaining of GFP-LC3B with LysoTracker Red or LAMP1 antibody demonstrates that autophagosome-lysosome fusion is blocked by OC treatment. Furthermore, OC inhibits lysosomal proteolytic activity by altering lysosomal acidification and downregulating the expression of lysosomal cathepsins. Importantly, OC can eliminate the tolerance of cancer cells to nutrient starvation. Starvation dramatically increases the susceptibility of cancer cells to OC-induced CASP3-dependent apoptosis in vitro. Subsequent studies in xenograft mouse model showed that OC has anticancer potency as revealed by increased staining of cleaved CASP3, LC3 puncta, and SQSTM1, as well as reduced expression of lysosomal cathepsins. Combined treatment with OC and caloric restriction potentiates anticancer efficacy of OC in vivo. Collectively, these data demonstrated that OC is a novel autophagic flux inhibitor and might be useful in anticancer therapy.
The Association between Childhood Overweight and Reflux Esophagitis (2010)

Background. In adults, it has been shown that obesity is associated with gastroesophageal reflux disease (GERD) and GERD-related complications. There are sparse pediatric data demonstrating associations between childhood overweight and GERD. Objective. To investigate the association between childhood overweight and RE. Methods. We performed a retrospective chart review of 230 children (M : F = 114 : 116) who underwent esophagogastroduodenoscopy (EGD) with biopsies between January 2000 and April 2006. Patient demographics, weight, height, clinical indications for the procedure, the prevalence of BMI classification groups, the prevalence of RE and usage of anti-reflux medications were reviewed. For these analyses, the overweight group was defined to include subjects with BMI>/= 85th percentile. The normal weight group was defined to include subjects with BMI 5th to 85th percentile. Results. Among the 230 subjects, 67 (29.1%) had BMI percentiles above the 85th percentile for age and gender. The prevalence of RE in the overweight group did not differ significantly from that in the normal weight group (23.9% versus 24.5%, resp.). Overweight subjects taking anti-reflux medications clearly demonstrated a higher prevalence of biopsy-proven RE compared to overweight subjects not taking anti-reflux medications (34.1% versus 7.7%, P = .009). Conclusions. There was no significant difference in the prevalence of biopsy-proven RE in the overweight group compared to the normal weight group. However, the prevalence of RE was significantly higher in overweight subjects on anti-reflux medications compared to overweight subjects not taking anti-reflux medications. This finding emphasizes the importance of early recognition and treatment of GERD for the overweight pediatric patients with symptoms in conjunction with weight loss program for this population to reduce long-term morbidities associated with GERD.
Latin Historiography: A Survey, 1400-1600 (1955)

Flavio Biondo, writing in 1443 to Alfonso of Naples, explained his purpose in composing a history. All interested in the humanities realized, said he, that in twelve hundred years Italy had produced poets and orators, but practically no historians. Scholars had prepared translations from the Greek and philosophical treatises, yet their duty to history they had avoided, or touched upon in superficial fashion. This judgment was echoed by Bruni, Bonfini, Sabellico, and others, who regretted the lack of accounts of their medieval past. Church calendars had shaped the early recording of events. The language was Latin, the arrangement chronological, with no effort to group related occurrences or to indicate causation other than the will of God. The supernatural was readily accepted.
Drill collar length is a major factor in vibration control (1982)

Drill collar length directly affects the overall vibration response of drill strings. Drill collar length is partly responsible for severe vibrations in hard rock drilling but can also be the solution to vibration control. This paper gives a new interpretation to the cause and control of drill string vibrations and presents the results in terms of formulas that can be directly applied by the drilling engineer.
<title>Design And Assembly Of A High Resolution Schwarzschild Microscope For Soft X Rays</title> (1982)

Recently developed multilayer coatings permit use of normal incidence optics for soft x-rays promising a resolution that should be substantially better than that obtained with grazing incidence optics. We describe the design and assembly of a Schwarzschild objective for a scanning x-ray microscope. The Schwarzschild objective, consisting of two nearly concentric spherical mirrors promises diffraction-limited resolution for soft x-rays.
Specific Non-Native Hydrophobic Interactions in a Hidden Folding Intermediate:  Implications for Protein Folding (2003)

Structures of intermediates and transition states in protein folding are usually characterized by amide hydrogen exchange and protein engineering methods and interpreted on the basis of the assumption that they have native-like conformations. We were able to stabilize and determine the high-resolution structure of a partially unfolded intermediate that exists after the rate-limiting step of a four-helix bundle protein, Rd-apocyt b(562), by multidimensional NMR methods. The intermediate has partial native-like secondary structure and backbone topology, consistent with our earlier native state hydrogen exchange results. However, non-native hydrophobic interactions exist throughout the structure. These and other results in the literature suggest that non-native hydrophobic interactions may occur generally in partially folded states. This can alter the interpretation of mutational protein engineering results in terms of native-like side chain interactions. In addition, since the intermediate exists after the rate-limiting step and Rd-apocyt b(562) folds very rapidly (k(f) approximately 10(4) s(-1)), these results suggest that non-native hydrophobic interactions, in the absence of topological misfolding, are repaired too rapidly to slow folding and cause the accumulation of folding intermediates. More generally, these results illustrate an approach for determining the high-resolution structure of folding intermediates.
Experiences In The Precision Machining Of Grazing Incidence X-Ray Mirror Substrates (1986)

A brief description is given of the successful development of a large computer controlled machine for diamond turning aluminium alloy X-ray mirror substrates (1.5 m (60 in.) dia., 600 mm (24 in.) axial length). The in situ metrology facility for axial profile, round-ness and diameter measurement is described, together with the technique for automatic programming of the final tool path to compensate for errors of workpiece deflection, tool setting and edge radius, etc.. Examples are based on the ROSAT and SXT mirrors for which the axial and radial location/mounting surfaces are produced with precise reference to the reflecting surfaces. Adaptation of this type of precision machine/metrology facility to the production of glass ceramic optical components is also discussed.
The Addition of Arylselenium Trichlorides <i>vs</i>. Areneselenenyl Chlorides to <i>cis</i>- and <i>trans</i>-1-Phenylpropene (1974)

2,4-Dinitrophenylselenium trichloride has been found to add to cis- and trans-1-phenylpropene in an anti stereospecific manner to yield threo-dl-and erythro-dl-β-chloroalkyl 2,4-dinitrophenyl selenide dichlorides, respectively. Comparison is made with the adducts from the addition of 2,4-dinitrobenzeneselenenyl chlorides. β-Chloroalkyl 2,4-dinitrophenyl selenides react with chlorine or sulfuryl chloride to yield β-chloroalkyl 2,4-dinitrophenyl selenide dichlorides. β-Chloroalkyl selenide dichlorides were observed to decompose into 1,2-dichloro adducts and areneselenenyl chloride. 2,4-Dinitrobenzeneselenenyl acetate was shown to add to alkenes in an anti stereospecific manner.
Production of a Biodegradable Plastic Polymer, Poly-β-Hydroxybutyrate, in Transgenic Alfalfa (2002)

Alfalfa (Medicago sativa L.) is primarily used as a source of forage and animal feed. Improving the economic value of alfalfa could be achieved by developing new uses of this perennial crop. To investigate the potential of alfalfa as a source of industrial materials, we employed a genetic transformation approach to produce a biodegradable plastic, poly-β-hydroxybutyrate (PHB), in the leaves of alfalfa plants. Three genes from Ralstonia eutropha (formerly Alcaligenes eutrophus) encoding the enzymes for synthesis of PHB (phbA, phbB, phbC) and a copolymer of PHB and polyhydroxyvalerate (polyhydroxybutyrate-co-hydroxyvalerate, or PHB/V) (bktB, phbB, phbC) engineered for plastid targeting were introduced into alfalfa by Agrobacterium-mediated transformation. DNA and RNA blot analyses of transgenic plants indicated integration and expression of the PHB biosynthetic pathway genes. Polyhydroxybutyrate content in the leaves of transgenic plants ranged from ≈0.025 to 1.8 g kg−1 dry weight (DW). Agglomerations of PHB granules 0.2 to 0.4 μm in diameter, similar to bacterial PHB, were located in the chloroplasts of transgenic plants, demonstrating that phb gene products were targeted into the plastids of transgenic alfalfa. Transgenic plants exhibited growth similar to untransformed plants, suggesting that expression of PHB biosynthetic pathway genes at current levels and accumulation of product in the plastids had no deleterious effect on growth and fertility. F1 hybrid progeny, obtained from crosses of PHB transgenic plants with elite alfalfa germplasm, exhibited leaf PHB levels similar to the transgenic parental line, demonstrating that PHB production in alfalfa is a stable and dominantly inherited trait.
Cure of Carbon Black–Unsaturated Polyester Mixtures (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCure of Carbon Black–Unsaturated Polyester MixturesC. W. Sweitzer, F. Lyon, and T. S. GrabowskiCite this: Ind. Eng. Chem. 1955, 47, 11, 2380–2385Publication Date (Print):November 1, 1955Publication History Published online1 May 2002Published inissue 1 November 1955https://pubs.acs.org/doi/10.1021/ie50551a051https://doi.org/10.1021/ie50551a051research-articleACS PublicationsRequest reuse permissionsArticle Views112Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Thinning Effects of Bloomtime Gibberellin Sprays on Thompson Seedless Table Grapes (1966)

Gibberellin sprays applied during the bloom period to Thompson Seedless vines used for table grapes resulted in a decrease in berry set, an increase in berry size, and higher soluble solids. The berries were also elongated by the gibberellin treatments. Gibberellin concentrations of 10 and 20 ppm produced loose, attractive clusters. Concentrations of 25, 50, and 100 ppm induced the development of undesirable shot berries. There were no significant differences in berry set between the 10- and 20-ppm treatments or between spraying at 10 and 70% bloom. The berry thinning effect from the gibberellin was relatively uniform throughout the cluster. This is important in market acceptance of table grapes.
Occlusion Geodesics for Online Multi-object Tracking (2014)

Robust multi-object tracking-by-detection requires the correct assignment of noisy detection results to object trajectories. We address this problem by proposing an online approach based on the observation that object detectors primarily fail if objects are significantly occluded. In contrast to most existing work, we only rely on geometric information to efficiently overcome detection failures. In particular, we exploit the spatio-temporal evolution of occlusion regions, detector reliability, and target motion prediction to robustly handle missed detections. In combination with a conservative association scheme for visible objects, this allows for real-time tracking of multiple objects from a single static camera, even in complex scenarios. Our evaluations on publicly available multi-object tracking benchmark datasets demonstrate favorable performance compared to the state-of-the-art in online and offline multi-object tracking.
R-URC: Smartphone based RF4CE Universal Remote Control Framework (2010)

RC(Remote Control) is a technology that can efficiently control and transfer a variety of user commands to CEs. However, the existing RCs have been required various additional features such as communication between CEs, extension of communication range, low power-consumption and bi-directional communication according to the advent of new types of CE devices and its enhanced performance. Even though RC controller has many customers' requests, it is not a simple solution because most legacies work on IR-based RC. In this paper, we propose RF4CE-based Universal Remote Control Framework using Smartphone in order to solve the many constraints of IR legacies. The proposed R-URC system is designed by RF4CE platform which is a kind of de-facto standard for CE remote control communication. From the verification scenarios using various CEs and smart phone, we can see that the proposed R-URC shows the good practical usage in terms of contents sharing and smart CE control.
Automated mosaics via topology inference (2002)

The authors present a complete approach for the automated construction of mosaics from images and video using topology inference, local and global alignment, and compositing.
Thematic review series: Adipocyte Biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis (2007)

The majority of eukaryotic cells synthesize neutral lipids and package them into cytosolic lipid droplets. In vertebrates, triacylglycerol-rich lipid droplets of adipocytes provide a major energy storage depot for the body, whereas cholesteryl ester-rich droplets of many other cells provide building materials for local membrane synthesis and repair. These lipid droplets are coated with one or more of five members of the perilipin family of proteins: adipophilin, TIP47, OXPAT/MLDP, S3-12, and perilipin. Members of this family share varying levels of sequence similarity, lipid droplet association, and functions in stabilizing lipid droplets. The most highly studied member of the family, perilipin, is the most abundant protein on the surfaces of adipocyte lipid droplets, and the major substrate for cAMP-dependent protein kinase [protein kinase A (PKA)] in lipolytically stimulated adipocytes. Perilipin serves important functions in the regulation of basal and hormonally stimulated lipolysis. Under basal conditions, perilipin restricts the access of cytosolic lipases to lipid droplets and thus promotes triacylglycerol storage. In times of energy deficit, perilipin is phosphorylated by PKA and facilitates maximal lipolysis by hormone-sensitive lipase and adipose triglyceride lipase. A model is discussed whereby perilipin serves as a dynamic scaffold to coordinate the access of enzymes to the lipid droplet in a manner that is responsive to the metabolic status of the adipocyte.
Induction of embryonic dysmorphogenesis by high glucose concentration, disturbed inositol metabolism, and inhibited protein kinase C activity (2001)

High glucose concentration causes dysmorphogenesis in embryos by an interaction of oxidative stress and inositol depletion.
The prototype design of gFEX — a component of the l1calo trigger for the ATLAS phase-I upgrade (2016)

The ATLAS experiment will follow the upgrade steps of the Large Hadron Collider (LHC), which will undergo a series of upgrades to increase the luminosity in the next ten years. During the Phase-I upgrade, a new component will be designed for the ATLAS Level-1 calorimeter trigger system to maintain the trigger acceptance against the increasing luminosity - the global feature extractor (gFEX). The gFEX is intended to identify patterns of energy associated with the hadronic decays of high momentum Higgs, W & Z bosons, top quarks and exotic particles in real time at the LHC crossing rate. A prototype v1 with one System-on-Chip Xilinx ZYNQ FPGA, and one Vertex-7 FPGA for technology validation has been designed and tested in 2015. With the lessons learned from the prototype v1, a prototype v2 with three UltraScale FPGAs and one ZYNQ FPGA is implemented on an ATCA module. This board will receive coarse-granularity information from the entire ATLAS calorimeter on 276 optical fibers at the speed up to 12.8 Gb/s synchronous to the 40 MHz LHC clock. The test results of the prototype v2 show that the main gFEX functionalities are working well. Currently it is being used as the test platform for trigger algorithm development and integration with other detector systems. Based on the prototype v2 design, a prototype v3 design, the final prototype before production, has been started. This features a ZYNQ UltraScale+ FPGA and more fiber optical links to provide compatibility for the High-Luiminosity upgrade of the LHC (HL-LHC).
Treatment of Multidrug-Resistant Tuberculosis (1993)

The frequency of infections with M. tuberculosis resistant to antituberculous drugs is increasing in the United States and globally. This increase is a major threat to tuberculosis treatment and control programs. To prevent this situation from worsening, initial treatment programs that entail directly observed therapy supported by effective inducements or enforcements must be used. Retreatment of patients who have multidrug-resistant tuberculosis should be carried out in programs with comprehensive microbiologic, pharmacokinetic, psychosocial, and nutritional support systems. Regimens of multiple drugs, which generally are poorly tolerated and more toxic than traditional regimens, must be administered for 18 to 36 months. Resectional surgery may be required for substantial numbers of patients. For patients with AIDS who acquire tuberculosis caused by multiply-resistant strains, the disease may prove lethal before effective therapy can be implemented. Ultraviolet irradiation systems should be used to protect health care personnel and other patients in high-risk environments. Enhanced federal, state, and local programs for prevention and control are urgently needed, and research to identify new medications and systems for their delivery is essential.
The Advent of Competition and Credit Control (1983)

In May 1971 the Bank of England published a consultative document entitled Competition and Credit Control which heralded the adoption of a new approach to monetary control. The aims of reform were threefold: to increase competition within the banking sector; to improve the bank regulatory system for demand-management purposes; and finally, to enhance the authorities’ ability to control the money stock.
High-speed droplet generation on demand driven by pulse laser-induced cavitation (2011)

We report on a pulse laser-driven droplet generation (PLDG) mechanism that enables on-demand droplet generation at rates up to 10,000 droplets per second in a single-layer PDMS-based microfluidic device. Injected droplet volumes can be continuously tuned between 1 pL and 150 pL with less than 1% volume variation.
FEncy: Spreadsheet Formulae Exploration. (2014)

Abstract. Spreadsheets are well-known to be frequently-used but error-prone communication devices. They are useful since they are active (e.g., automatic computation), provide a cognitive notation system drawing on visualizing val-ues, meanings and relations at the same time (enabled by labeled, color-coded grids), and provide easy-to-use domain-specific operations (e.g., computational functions). The latter, in particular, is enabled by the text-style formula format in spreadsheets, in which variables are replaced by cell references. For simply-structured formulae this works very well. To keep the formulae simple, computa-tions are modularized into subformulae and as such distributed over and beyond the spreadsheet. This makes the provenance (tree) of spreadsheet values difficult to understand – a probable cause for the high error rate in spreadsheets. To explore and navigate the subformulae involved in the computation of a cell value we present the subformula explorer “FEncy”, a tree-based, explorative in-terface: Whenever a user clicks on a cell its formula becomes the root of a cell-dependency graph. Each child node displays the formula of a cell (or range) ref-erence used in the parent formula either in the original text-style or potentially in math notation. Moreover, each node represents a direct link to the respective cell (or range), so that it can be used for formula navigation as well. 1