gebhart/patrepeval huggingface dataset:
Line and receiver interface circuit for high-speed voice-band modems (1987)

A single-chip implementation of the analog signal processing functions required for full-duplex voice-band modem operation over twisted pair wires is described. Echo path signal-to-signal harmonic distortion plus noise exceeds 65 dB. The device is implemented in a 3.5-/spl mu/m twin-tub CMOS process, and typically dissipates 180 mW.
Panoramic stereo photography based on single-lens with a double-symmetric prism (2013)

Different from traditional panorama stereo acquisition technique shooting with numerous cameras, this study equips a double-symmetric prism in front of a single-lens camera to acquire images from four different angles of view, and the images acquired from the cameras every 20 degrees complete a pair of panorama stereo images with vertical angle of view ( ± 16 degrees) by image-based rendering. The panorama stereo acquisition technique reduces the number of cameras by three-fourth, and the acquired images contain vertical angles of view. Moreover, the image resolution is enhanced several times of the resolution of integral photography without moiré effect.
Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor. (2002)

DNA topoisomerase II has been shown to be an important therapeutic target in cancer chemotherapy. Here, we describe studies on the antitumor activity of a novel topoisomerase II inhibitor, ER-37328 [12,13-dihydro-5-[2-(dimethylamino)ethyl]-4H-benzo[c]pyrimido[5,6,1- jk]carbazole-4,6,10(5H,11H)-trione hydrochloride]. ER-37328 inhibited topoisomerase II activity at 10 times lower concentration than etoposide in relaxation assay and induced double-strand DNA cleavage within 1 h in murine leukemia P388 cells, in a bell-shaped manner with respect to drug concentration. The maximum amount of DNA cleavage was obtained at 2 microM. Like etoposide, ER-37328 (2 microM) induced topoisomerase II-DNA cross-linking in P388 cells. A spectroscopic study of ER-37328 mixed with DNA demonstrated that ER-37328 has apparent binding activity to DNA. ER-37328 showed potent growth-inhibitory activity against a panel of 21 human cancer cell lines [mean (50% growth-inhibitory concentration) GI50 = 59 nM]. COMPARE analysis according to the National Cancer Institute screening protocol showed that the pattern of the growth-inhibitory effect of ER-37328 was similar to that of etoposide, but different from that of doxorubicin. Studies on etoposide-, amsacrine [4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA)]-, and camptothecin-resistant P388 cell lines showed that: (a) etoposide- and m-AMSA-resistant P388 cell lines were partially resistant to ER-37328 compared with the parental cell line; and (b) a camptothecin-resistant cell line showed no cross-resistance to ER-37328. In addition, ER-37328 overcame P-glycoprotein-mediated resistance. In vivo, ER-37328 produced potent tumor regression of Colon 38 carcinoma inoculated s.c., and its activity was superior to that of etoposide or doxorubicin. These results indicate that ER-37328 inhibits topoisomerase II activity through the formation of topoisomerase II-DNA cleavable complex and has potent antitumor activity both in vitro and in vivo.
60 YEARS OF NEUROENDOCRINOLOGY: Acromegaly (2015)

Acromegaly (ACM) is a chronic, progressive disorder caused by the persistent hypersecretion of GH, in the vast majority of cases secreted by a pituitary adenoma. The consequent increase in IGF1 (a GH-induced liver protein) is responsible for most clinical features and for the systemic complications associated with increased mortality. The clinical diagnosis, based on symptoms related to GH excess or the presence of a pituitary mass, is often delayed many years because of the slow progression of the disease. Initial testing relies on measuring the serum IGF1 concentration. The oral glucose tolerance test with concomitant GH measurement is the gold-standard diagnostic test. The therapeutic options for ACM are surgery, medical treatment, and radiotherapy (RT). The outcome of surgery is very good for microadenomas (80-90% cure rate), but at least half of the macroadenomas (most frequently encountered in ACM patients) are not cured surgically. Somatostatin analogs are mainly indicated after surgical failure. Currently their routine use as primary therapy is not recommended. Dopamine agonists are useful in a minority of cases. Pegvisomant is indicated for patients refractory to surgery and other medical treatments. RT is employed sparingly, in cases of persistent disease activity despite other treatments, due to its long-term side effects. With complex, combined treatment, at least three-quarters of the cases are controlled according to current criteria. With proper control of the disease, the specific complications are partially improved and the mortality rate is close to that of the background population.
Demonstrating the safety of manuka honey UMF<sup>®</sup> 20+in a human clinical trial with healthy individuals (2010)

Honey is an established traditional medicine with a variety of putative nutritional and health effects, including antibacterial, antioxidant, anti-inflammatory and prebiotic. The aim of the present study was to investigate the safety of consuming manuka honey, UMF ® 20+, on healthy individuals by establishing whether UMF ® 20+caused an allergic response (as measured by IgE levels), changed major commensal and beneficial microbial groups in the gut and/or affected levels of one of the most common advanced glycation endpoints, N ɛ -(carboxymethyl)-lysine (CML). The study had a randomised, double-blind cross-over design. A total of twenty healthy individuals aged 42–64 years were recruited. We tested two different honeys– a multiflora honey and UMF ® 20+, both produced by Comvita New Zealand Ltd (Te Puke, New Zealand). Multiflora honey or UMF ® 20+(20 g) was consumed daily for 4 weeks, with a 2-week ‘washout’ period in between. Blood samples were collected every week for each intervention period and used to measure total IgE levels in serum and advanced glycation endproducts – a consequence of methyglyoxal accumulation. Faecal samples were collected at the beginning and end of each 4-week period. DNA was extracted from faecal samples and the levels of a number of microbial groups in the gut, both beneficial and commensal, were analysed. Neither product changed the levels of IgE or CML or altered gut microbial profiles during the trial, confirming that UMF ® 20+is safe for healthy individuals to consume. Despite anecdotal evidence suggesting that manuka honey is good for digestive health, we observed no beneficial effects on lower gut bacterial levels with either honey in this healthy population.
Magnetoresistive sensors for nondestructive evaluation (Invited Paper) (2005)

New high-sensitivity solid-state magnetoresistive (MR) sensor technologies offer significant advantages in nondestructive evaluation (NDE) systems. A key advantage of MR sensors is a flat frequency response extending from dc to hundreds of MHz, making them particularly attractive for low-frequency and multi-frequency eddy current detection for deep-flaw detection and depth profiling. MR sensors are mass produced by thin film processing techniques similar to integrated circuit manufacturing, dramatically reducing the cost per sensor. The fabrication process is compatible with silicon circuit technology, allowing integration of sensors with on-chip signal processing. MR sensors can easily be produced in dense arrays for rapid, single-pass scanning of large areas. The small size and low power consumption of these solid-state magnetic sensors enable the assembly of compact arrays of sensors on a variety of substrates as well as on-chip sensor arrays. Arrays have been fabricated with sensor spacing as small as 5 μm. This paper presents a review of the state of the art in MR sensors and applications in NDE. The physical principles, manufacturing process, and performance characteristics of the three main types of MR devices, anisotropic magnetoresistance (AMR), giant magnetoresistance (GMR) and tunneling magnetoresistance (TMR) are discussed. Their performance is compared to other magnetic sensor technologies for NDE applications. Finally, we provide a comprehensive review of the literature on NDE applications of MR sensors.
AS03- and MF59-Adjuvanted Influenza Vaccines in Children (2017)

Influenza is a major cause of respiratory disease leading to hospitalization in young children. However, seasonal trivalent influenza vaccines (TIVs) have been shown to be ineffective and poorly immunogenic in this population. The development of live-attenuated influenza vaccines and adjuvanted vaccines are important advances in the prevention of influenza in young children. The oil-in-water emulsions MF59 and adjuvant systems 03 (AS03) have been used as adjuvants in both seasonal adjuvanted trivalent influenza vaccines (ATIVs) and pandemic monovalent influenza vaccines. Compared with non-adjuvanted vaccine responses, these vaccines induce a more robust and persistent antibody response for both homologous and heterologous influenza strains in infants and young children. Evidence of a significant improvement in vaccine efficacy with these adjuvanted vaccines resulted in the use of the monovalent (A/H1N1) AS03-adjuvanted vaccine in children in the 2009 influenza pandemic and the licensure of the seasonal MF59 ATIV for children aged 6 months to 2 years in Canada. The mechanism of action of MF59 and AS03 remains unclear. Adjuvants such as MF59 induce proinflammatory cytokines and chemokines, including CXCL10, but independently of type-1 interferon. This proinflammatory response is associated with improved recruitment, activation and maturation of antigen presenting cells at the injection site. In young children MF59 ATIV produced more homogenous and robust transcriptional responses, more similar to adult-like patterns, than did TIV. Early gene signatures characteristic of the innate immune response, which correlated with antibody titers were also identified. Differences were detected when comparing child and adult responses including opposite trends in gene set enrichment at day 3 postvaccination and, unlike adult data, a lack of correlation between magnitude of plasmablast response at day 7 and antibody titers at day 28 in children. These insights show the utility of novel approaches in understanding new adjuvants and their importance for developing improved influenza vaccines for children.
A novel algorithm for identification and tracking of power system harmonics (2004)

A novel and efficient linear least squares algorithm for a real time measurement technique that can track the harmonics in power system waveforms is presented. The proposed algorithm does not require matrix inversion. The technique produces accurate real time measurements of the amplitude and phase of the harmonics present in a power system. To verify the theoretical analysis, computer simulation has been used and tested with a hypothetical signal. The results obtained confirm that the method is computationally efficient and suitable for real time applications. The simulation has shown that the computational requirement has been reduced significantly and that the identification of harmonics buried in a noisy signal is accurate.
Undergraduate Analytical Chemistry (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUndergraduate Analytical ChemistryJ. W. RobinsonCite this: Anal. Chem. 1968, 40, 11, 33A–36APublication Date (Print):September 1, 1968Publication History Published online22 May 2012Published inissue 1 September 1968https://pubs.acs.org/doi/10.1021/ac60267a728https://doi.org/10.1021/ac60267a728research-articleACS PublicationsRequest reuse permissionsArticle Views22Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reversible axial segregation of rotating granular media (1995)

Experimental measurements of axial segregation of binary mixtures of granular media combined in a horizontal cylinder and rotated like a drum mixer are reported. While in the traditional axial segregation effect the mixture of two different sizes of granular media will separate into bands of relatively pure single concentrations along the axis of rotation, in special cases the homogeneous mixed state can be restored simply by decreasing the speed of rotation. Systematic variation of the relative diameters of the components reveal three classes of behavior: no segregation at any rotation speed, a nonreversible axial segregation, and an axial segregation at high speeds that reverses back into the mixed state at low speeds. Measurements of the dynamic angle of repose of the mixed and segregated phases as a function of rotation speed support a model for the axial segregation effect that involves a diffusion equation with an effective axial diffusion coefficient that can be negative under the conditions for which segregation occurs.
Demonstration and system analysis of the HORNET architecture (2003)

The HORNET architecture is a packet-over-wavelength-division-multiplexing ring network that utilizes fast-tunable packet transmitters and wavelength routing to enable it to scale cost-effectively to ultrahigh capacities. In this paper, we present the HORNET architecture and a novel control-channel-based media access control protocol. The survivability of the architecture is demonstrated with an experimental laboratory testbed. Mathematical analysis of the architecture shows that the wavelength routed network can scale to relatively large sizes ranging between 30 and 50 nodes, depending on the component performance. This is true even for arrangements that do not contain high-power optical amplifiers in every node.
Dielectric characterization of B<sub>3</sub>and B<sub>4</sub>phases (2000)

Dielectric measurements on two samples formed from banana-shaped molecules with terminal alkyl or alkyloxy groups were carried out in a frequency range between 10-3 Hz and 10 MHz. Both samples exhibit B2 and B3 phases; one of them has a B4 state as well. As usual, two ranges of relaxation were detected in the B2 phase, the fast reorientation about the long axes of the molecules and a slow collective process. Only one dielectrically active low frequency process could be separated in the B3 and B4 phases; this is probably related to the dynamics of superstructures. The high frequency limit of the dielectric constants gives a hint that neither phase is a classical solid. A quite strong increase in the conductivity at the transition into the B3 phase is critically discussed.
Sodium Butyrate Promotes Generation of Human Induced Pluripotent Stem Cells Through Induction of the miR302/367 Cluster (2013)

Small molecules (SM) can greatly enhance the efficiency of induced pluripotent stem (iPS) cell generation, but the mechanisms by which they act have not been fully explored. We show here that an SM cocktail (NaB, PD03259, and SB431542) significantly promotes iPS cell generation from human fibroblasts, and NaB is more potent than the other two common histone deacetylase inhibitors (valproic acid and Trichostatin A) in promoting cellular reprogramming. Our data indicate that the SM cocktail substantially upregulates the miR302/367 cluster expression by increasing the stability and transcriptional level of this microRNA (miRNA) cluster in a manner dependent on the four defined transcription factors (TFs). Among the four TFs, Oct4 in particular appears to be required for the induction of the miR302/367 cluster by the SM cocktail. We also found that NaB alone can enhance the TFs-dependent upregulation of the miR302/367 cluster. Using a promoter reporter assay, we show that the SM cocktail remarkably enhanced the transcriptional activity of the four TFs in the miR302/367 promoter. Notably, attenuation of miRNA302/367 using a miRZip impairs the ability of the SM cocktail in promoting reprogramming. Collectively, these findings suggest that the SM cocktail promotes reprogramming at least partly through the induction of the miR302/367 cluster expression. Further insights into this process may pave the way for the generation of iPS cells using only SM cocktails.
The Advantages and Importance of Learning and Using Idioms in English (2009)

This article has as main purpose to share the results of a small scale project based on guiding students in the use of idioms through dialogues and readings, in order to improve students' communicative skill. The project was applied at Universidad Santo Tomás - Tunja, with one group of eleven Electronic Engineering students who attend to an undergraduate education program. Dialogues, interviews, and informal speech or conversations were used to collect the data in this action research study. Findings demonstrated that by learning and using some idioms the learners were able to increase their knowledge about idioms, they learned new vocabulary, and improved their communicative skill.
Inhibition of Cholesteryl Ester Transfer Protein by Torcetrapib Modestly Increases Macrophage Cholesterol Efflux to HDL (2007)

These data indicate that inhibition of CETP by torcetrapib causes a modest increase in the ability of HDL to promote net cholesterol efflux at the 60 mg dose, and a more dramatic increase at the 120 mg dose in association with enhanced particle functionality.
Incidence of Regional Recurrence Guiding Radicality in Differentiated Thyroid Carcinoma (1996)

Total thyroidectomy has become the routine procedure for treatment of differentiated thyroid carcinoma. However, the necessity of unilateral or bilateral neck dissection is far less standardized. Our usual procedure has been to perform a routine neck dissection in T4 tumors and in all other tumor stages only in the presence of positive diagnostic or intraoperative findings. The results concerning regional tumor recurrence in cervical lymph nodes subsequent to thyroidectomy are studied and discussed. Between April 1986 and December 1992 a group of 252 patients were operated on for differentiated thyroid carcinoma (DTC) (176 papillary, 76 follicular). Postoperative treatment included radioiodine therapy as a rule in all patients more than stage T1, and follow-up encompassed thyroglobulin measurements, cervical ultrasonography, and radioiodine scintigraphy. After a mean follow-up of 6.9 years, 77 (31%) of the patients underwent reoperation because of regional tumor recurrence [46 of 176 (26%) papillary, 31 of 76 (41%) follicular]. In papillary thyroid cancer a significant difference could be demonstrated between patients with thyroidectomy only versus thyroidectomy plus neck dissection in all tumor stages (T2, 13 of 29 (45%) versus 1 of 34 (3%); T3, 10 of 13 (77%) versus 4 of 11 (36%); T4, 6 of 8 (75%) versus 6 of 18 (33%) (p < 0.0001). Similar results could be achieved for follicular thyroid cancer, showing statistical significance with regard to operative procedure (p < 0.009). Our experience demonstrates a positive correlation of regional tumor recurrence with increasing tumor stage for both histologic tumor types. The high rate of regional recurrence justifies a more radical approach, including neck dissection at the initial operation. The impact on survival, however, must be proved by further evaluation.
The role of leadership in successful vocational initiatives (2001)

Abstract Vocational education is occurring in an environment of new technologies, global competition, and changing demographics that is transforming community colleges. Leaders with foresight and courage will have a positive influence on their institutions and promote the new vocationalism.
High-Dose Naloxone Infusions in Normals (1983)

Hypotheses of involvement of the endogenous opioid system (EOS) in the regulation of human behavior suggest that functional blockade of the EOS should have behavioral consequences. Clinical administration of the opiate receptor antagonist naloxone hydrochloride, however, has had little or inconsistent behavioral effects in normals. This may be attributable to the use of doses insufficient to yield a complete EOS blockade. To assess this explanation, normals were administered increasing doses of naloxone hydrochloride (0.3 to 4 mg/kg) in a single-blind design. Significant dose-dependent behavioral, hormonal, and physiological effects were found. With increasing doses of naloxone, volunteers demonstrated increasingly dysphoric affects, a deterioration of performance on memory testing, increasing systolic BP and respiratory rate, and increasing plasma cortisol and growth hormone levels. These results are consistent with the expected effects of increasing EOS blockade, and thus suggest that lower doses of naloxone used in previous clinical studies may not have been sufficient to produce a complete EOS blockade. Specifically, they suggest involvement of the EOS in the tonic regulation of normal human mood, memory, BP, respirations, and plasma growth hormone and cortisol levels.
Arbitrary view generation for three-dimensional scenes from uncalibrated video cameras (2002)

This paper focuses on the representation and arbitrary view generation of three dimensional (3-D) scenes. In contrast to existing methods that construct a full 3-D model or those that exploit geometric invariants, our representation consists of dense depth maps at several preselected viewpoints from an image sequence. Furthermore, instead of using multiple calibrated stationary cameras or range data, we derive our depth maps from image sequences captured by an uncalibrated camera. We propose an adaptive matching algorithm which assigns various confidence levels to different regions. Nonuniform bicubic spline interpolation is then used to fill in low confidence regions in the depth maps. Once the depth maps are computed at preselected viewpoints, the intensity and depth at these locations are used to reconstruct arbitrary views of the 3-D scene. Experimental results are presented to verify our approach.
Acceleration of tetramer formation by the binding of inositol hexaphosphate to hemoglobin dimers. (1975)

The aggregation of deoxyhemoglobin dimers was studied by dropping the pH of a dilute solution of deoxyhemoglobin originally at high pH. In the presence of inositol hexaphosphate, a sharp increase in the rate of dimer association was observed. At higher concentrations of the phosphate, the rate decreased to a value close to that seen in the absence of phosphate. These observations require that inositol hexaphosphate binds to deoxyhemoglobin dimers. The dependence of the aggregation rate on phosphate concentration occurs because the reaction of a dimer containing bound phosphate with a phosphate-free dimer is 30 to 50 times faster than either the association of phosphate-free dimers or the association of dimers both containing bound phosphate.
Optical coherence tomography and retinal pathology in neurologic diseases (2015)

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