gebhart/patrepeval huggingface dataset:
Mussel inspired protein‐mediated surface modification to electrospun fibers and their potential biomedical applications (2012)

Mussel inspired proteins have been demonstrated to serve as a versatile biologic adhesive with numerous applications. The present study illustrates the use of such Mussel inspired proteins (polydopamine) in the fabrication of functionalized bio-inspired nanomaterials capable of both improving cell response and sustained delivery of model probes. X-ray photoelectron spectroscopy analysis confirmed the ability of dopamine to polymerize on the surface of plasma-treated, electrospun poly(ε-caprolactone) (PCL) fiber mats to form polydopamine coating. Transmission electron microscopy images demonstrated that self-polymerization of dopamine was induced by pH shift and that the thickness of polydopamine coating was readily modulated by adjusting the concentration of dopamine and reaction time. Polydopamine coatings were noted to affect the mechanical properties of underlying fiber mats, as mechanical testing demonstrated a decrease in elasticity and increase in stiffness of polydopamine-coated fiber mats. Polydopamine coatings were also utilized to effectively immobilize extracellular matrix proteins (i.e., fibronectin) on the surface of polydopamine-coated, electrospun fibers, resulting in enhancement of NIH3T3 cell attachment, spreading, and cytoskeletal development. Comparison of release rates of rhodamine 6G encapsulated in coated and uncoated PCL fibers also confirmed that polydopamine coatings modulate the release rate of loaded payloads. The authors further demonstrate the significant difference of rhodamine 6G adsorption kinetics in water between PCL fibers and polydopamine-coated PCL fibers. Taken together, polydopamine-mediated surface modification to electrospun fibers may be an effective means of fabricating a wide range of bio-inspired nanomaterials with unique properties for use in tissue engineering, drug delivery, and advanced biomedical applications.
Security informatics research challenges for mitigating cyber friendly fire (2014)

This paper addresses cognitive implications and research needs surrounding the problem of cyber friendly fire (FF). We define cyber FF as intentional offensive or defensive cyber/electronic actions intended to protect cyber systems against enemy forces or to attack enemy cyber systems, which unintentionally harms the mission effectiveness of friendly or neutral forces. We describe examples of cyber FF and discuss how it fits within a general conceptual framework for cyber security failures. Because it involves human failure, cyber FF may be considered to belong to a sub-class of cyber security failures characterized as unintentional insider threats. Cyber FF is closely related to combat friendly fire in that maintaining situation awareness (SA) is paramount to avoiding unintended consequences. Cyber SA concerns knowledge of a system’s topology (connectedness and relationships of the nodes in a system), and critical knowledge elements such as the characteristics and vulnerabilities of the components that comprise the system and its nodes, the nature of the activities or work performed, and the available defensive and offensive countermeasures that may be applied to thwart network attacks. We describe a test bed designed to support empirical research on factors affecting cyber FF. Finally, we discuss mitigation strategies to combat cyber FF, including both training concepts and suggestions for decision aids and visualization approaches.
Development of Nanoscale Interdigitated Array Electrode as Electrochemical Sensor Platform for Highly Sensitive Detection of Biomolecules (2008)

We studied nanoscale interdigitated array electrodes (nano-IDAEs) to create a detector platform for highly sensitive biosensing devices. We successfully fabricated a gold nano-IDAE with 1000 pairs of electrodes (width and gap both 250 nm) and a 1 mm band length. We also fabricated a series of IDAEs whose widths and gaps ranged from 250 nm to , and performed cyclic voltammetry with the IDAEs using of ferrocenylmethyl trimethyl ammonium bromide solution to evaluate their characteristics. As the width and gap (line and space) of the IDAEs decreased, the difference between the experimental and theoretical limiting currents became larger, and when the line and space were 250 nm, the limiting currents were 20% higher than the theoretical value. We also employed the nano-IDAEs for measuring adrenaline. We demonstrated that the collection efficiency of 0% obtained when using a IDAE could be improved to more than 60% when using a 250 nm IDAE.
DataToon (2019)

Comics are an entertaining and familiar medium for presenting compelling stories about data. However, existing visualization authoring tools do not leverage this expressive medium. In this paper, we seek to incorporate elements of comics into the construction of data-driven stories about dynamic networks. We contribute DataToon, a flexible data comic storyboarding tool that blends analysis and presentation with pen and touch interactions. A storyteller can use DataToon rapidly generate visualization panels, annotate them, and position them within a canvas to produce a visually compelling narrative. In a user study, participants quickly learned to use DataToon for producing data comics.
Coastal Dynamics, East Coast of New Zealand, South Island (1977)

The paper examines the probable effects of hydro-electric and irrigation works on lower river and coastal systems along the east coast, South Island, in relation to accepted notions concerning the role of channel storage of sediments, modifications to fluvial flow regimes and the nature of river-beach exchanges. Problems are discussed in relation to changes in two river mouths over the past 24 years and with respect to an approximate sediment budget for one river. Direct river contributions to the coast are shown to be smaller than quantities released by shoreline erosion of unconsolidated gravel fans. The ultimate effect of hydro-electric works would be to accelerate coastal erosion while drawing off low flows for irrigation would lead to significant loss of recreational and wildlife amenities and probably increase flood risks adjacent to the lower reaches of the channels.
OFDM Guard Interval: Analysis and Observations (2007)

Orthogonal frequency division multiplexing (OFDM) is a modulation technique that is used in many modern digital communication systems and has been explored in numerous publications. Specifically, the tradeoff between throughput and ICI/ISI (intercarrier interference/intersymbol interference), which affects the length of the guard interval (GI) is well known. Many equalization methods that decrease the interference for a given (short) GI have been proposed. However, it seems that the exact expressions for the ICI and ISI have never been derived. In this paper these expressions are derived for a general (per tone equalization) setup. Often, the matched filter bound (MFB) for single carrier systems is used for OFDM systems. We make two new observations. First, we prove that under mild conditions, met in common scenarios, the ICI power and the ISI power are approximately equal. Second, we show by example that the MFB does not necessarily hold for OFDM. Both cyclic prefix (CP) and zeros prefix (ZP) are examined.
Word Embeddings for the Construction Domain (2016)

We introduce word vectors for the construction domain. Our vectors were obtained by running word2vec on an 11M-word corpus that we created from scratch by leveraging freely-accessible online sources of construction-related text. We first explore the embedding space and show that our vectors capture meaningful construction-specific concepts. We then evaluate the performance of our vectors against that of ones trained on a 100B-word corpus (Google News) within the framework of an injury report classification task. Without any parameter tuning, our embeddings give competitive results, and outperform the Google News vectors in many cases. Using a keyword-based compression of the reports also leads to a significant speed-up with only a limited loss in performance. We release our corpus and the data set we created for the classification task as publicly available, in the hope that they will be used by future studies for benchmarking and building on our work.
Research of Molded Line for Cylindrical Blade of Low Speed centrifugal pump (2009)

Based on the boundary conditions at blade inlet and outlet,the cubic polynomial is used to construct the expression of blade-type in polar coordinates;and the range of blade wrap angle which ensures that the vane setting angle varied monotonously is deduced.The main feature of this blade-type is that the wrapping angle is used as a designing constant,which can be preseted within a certain range.With the increase of blade radius,the blade radius of curvature increases monotonously,the vane setting angle changes monotonously and evenly.Thus the loss of off-flow on the surface of the blade is reduced and the efficiency of centrifugal pump is raised.
Ion acceleration in plasmas emerging from a helicon-heated magnetic-mirror device (2003)

Using laser-induced fluorescence, measurements have been made of metastable argon-ion, Ar+*(3d4F7/2), velocity distributions on the major axis of an axisymmetric magnetic-mirror device whose plasma is sustained by helicon wave absorption. Within the mirror, these ions have sub-eV temperature and, at most, a subthermal axial drift. In the region outside the mirror coils, conditions are found where these ions have a field-parallel velocity above the acoustic speed, to an axial energy of ∼30 eV, while the field-parallel ion temperature remains low. The supersonic Ar+*(3d4F7/2) are accelerated to one-third of their final energy within a short region in the plasma column, ⩽1 cm, and continue to accelerate over the next 5 cm. Neutral-gas density strongly affects the supersonic Ar+*(3d4F7/2) density.
CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus (2009)

T-cell development depends on recruitment of bone marrow-derived precursor cells to the thymus via a multistep adhesion cascade involving the chemokine receptor CCR9. However, CCR9 deficiency does not result in complete abrogation of progenitor entry into the adult thymus. Therefore, we tested the hypothesis that additional chemokine/chemokine receptor systems might play a role in this process. To this end, we generated mice deficient in both CCR9 and CCR7. Deficiency in both chemokine receptors resulted in severely reduced numbers of early T-cell progenitors and in near-complete abrogation of thymus reconstitution. Progenitors in bone marrow and peripheral blood remained largely unaffected in CCR7(-/-)CCR9(-/-) mice, and direct intrathymic transfer of precursors from CCR7(-/-)CCR9(-/-) mice as well as single-mutant mice showed that intrathymic differentiation of these precursors remained functional. Thus, our data reveal a previously unrecognized role of CCR7 in progenitor seeding of the adult thymus, which is largely masked by compensatory effects of CCR9 signals. In turn, CCR7 signals can partially compensate for CCR9 signals, thus explaining the rather mild phenotype of CCR9(-/-) mice with respect to progenitor seeding.
Access Restrictions to and with Description Logic Web Ontologies (2010)

Access restrictions are essential in standard information systems and became an issue for ontologies in the following two aspects. Ontologies can represent explicit and implicit knowledge about an access policy. For this aspect we provided a methodology to represent and systematically complete role-based access control policies. Orthogonally, an ontology might be available for limited reading access. Independently of a specific ontology language or reasoner, we provided a lattice-based framework to assign labels to an ontology’s axioms and consequences. We looked at the problems to compute and repair one or multiple consequence labels and to assign a query-based access restriction. An empirical evaluation has shown that the algorithms perform well in practical scenarios with large-scale ontologies.
Investigations on Structural and Electrochemical Properties of Some Disulfides Prepared by Schiff Base Reactions (2000)

Four different disulfides, [2,2′-dithiobis-(2-mercaptoacetophenone)]-4-triphenylmethylthiosemicarbazone (1), [5,5′-dithiobis-(4-formyl-3-methyl-1-phenylpyrazole)]-4-triphenylmethylthiosemicarbazone (2), bis[1-(2-mercaptophenyl)-2-(4-(1-phenyl-3-methyl)pyrazole)-azaethene]di-sulfide (3) and bis[1-phenyl-2-(4-(1-phenyl-3-methyl-5-mercapto) pyrazole)-azaethene]disulfide (4) were synthesized by Schiff base reactions. Their electrochemical behaviour was examined by cyclic voltammetry. The results show low potentials for the disulfide reduction so that these compounds are suitable for the syntheses of tridentate thiolate ligands from disulfides by electrochemical cleavage. In addition compounds 2 and 4 were characterized by X-ray structure determination. The structures show significant differences of the S—S bonds and angles as compared to other disulfides without bulky substituents.
Fluorination of amino alcohols and hydroxyaziridines by Olah's reagent (1983)

International audience
Corporate Price Policies as a Factor in the Recent Business Recession (1939)

Sumner H. Slichter, Corporate Price Policies as a Factor in the Recent Business Recession, Proceedings of the Academy of Political Science, Vol. 18, No. 2, Monopoly and Competition in Industry and Labor (Jan., 1939), pp. 20-33
Synthesis and Characterization of Cobalt−Complex Functionalized MCM-41 (1997)

Silanation of the internal pore surface of the mesoporous molecular sieve MCM-41 (40 Å) has yielded ethylenediamine (ED), diethylenetriamine (DET), and ethylenediaminetriacetic acid salt (EDT) functionalized sites. These grafted ligands were used for the preparation of cobalt(II) complexes covalently bound to the MCM-41 support. These materials were characterized by SEM, UV−vis, FTIR, ESR, and cyclic voltammetry as well as elemental analysis. Preliminary studies suggest the formation of a reversible cobalt−oxygen adduct with MCM-41 grafted ED and DET. The nature and reactivity of the MCM-41 bound complexes were found to differ significantly from functionalized amorphous silica.
Reproducibility of the distribution of carbon-11-SCH 23390, a dopamine D1 receptor tracer, in normal subjects. (1998)

The radioactivity ratio and the tissue-input Bmax/Kd may be preferred methods for the evaluation of dopamine D1 receptor binding because these two methods do not require arterial blood sampling and metabolite analysis. Our results show that cerebellum is a reliable reference region for SCH 23390. When the Logan plasma-input function method is used in data analysis for SCH 23390, DVRs rather than total DV values should be used because of the poor reliability of the DV values and their lack of correlation with other measures. Carbon-11-SCH 23390 is thus a reliable and reproducible ligand for the study of dopamine D1 receptor binding by PET.
Large‐Scale Synthesis of Titanate and Anatase Tubular Hierarchitectures (2007)

Tube to tube: Tubular anatase hierarchitectures have been prepared on a large scale from titanate structures with a similar morphology (see image). The as-obtained anatase hierarchitectures exhibit improved photocatalytic activity over Degussa P-25 and hollow rutile spheres, suggesting their application potential for catalysis. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2296/2007/z700179_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Seamless PAM-4 to QPSK Modulation Format Conversion at Gateway for Short-Reach and Long-Haul Integrated Networks (2018)

A direct optical PAM-4 to QPSK modulation format conversion using XPM in HNLF and a 20km-long SSMF transmission of the converted signal are experimentally demonstrated. SNR dependency on HNLF input-power tolerance of PAM4 signal is also reported.
Thin-film bulk acoustic wave resonators - FBAR: fabrication, heterogeneous integration with CMOS technologies and sensor applications (2008)

El gran impacto de la tecnologia FBAR tanto en sistemas de radio frecuencia como mas recientemente en sensores han motivado el desarrollo de aplicaciones integradas. Esto implica que los procesos de fabricacion deberian lograr producir dispositivos resonadores con un alto factor de calidad, al tiempo que permitir la integracion de los FBAR con tecnologias CMOS estandar. De tal manera, esta tesis doctoral aborda dichos requerimientos, contribuyendo con el diseno, fabricacion y caracterizacion de resonadores FBAR; su integracion con tecnologias CMOS estandar; y su aplicacion a sistemas de sensores. El desarrollo de la tecnologia de fabricacion de los FBAR ha involucrado la puesta a punto de las tecnicas de deposito y micro-mecanizacion de la estructura en capas del resonador, la cual esta comprendida por una pelicula de material acustico hecha de nitruro de aluminio (AlN). Se realizaron diversas pruebas para analizar la calidad del AlN depositado. Tambien se probaron y pusieron a punto diferentes tecnologias de micro¬mecanizacion para liberar la estructura del FBAR, destacando entre ellas la tecnica de ataque en seco por la cara de componentes, dados los altos factores de calidad obtenidos (superiores a 2.000 a 2,4 GHz). Sobre los dispositivos fabricados se realizaron caracterizaciones estructurales, modelos utilizando analisis de elementos finitos y la extraccion de parametros de circuito equivalente. Una variacion del proceso que involucraba el diseno, modelado y fabricacion de un dispositivo FBAR con compensacion de temperatura fue igualmente desarrollada. En este ambito vale la pena resaltar la concepcion y realizacion de una novedosa tecnica post-fabricacion para el ajuste fino de la frecuencia de resonancia de los FBAR por medio de un haz de iones focalizados (FIB). Basado en la tecnologia arriba mencionada, se desarrollo un metodo de integracion heterogenea a nivel de oblea de los dispositivos FBAR en sustratos CMOS estandar. De acuerdo con este metodo, se logro fabricar por primera vez dispositivos FBAR flotando sobre sustratos CMOS estandar. Este metodo ha sido exitosamente demostrado por medio de la integracion de los FBAR tanto con la tecnologia comercial AMS035 como con la CNM25, desarrollada en el CNM-IMB (CSIC). En el terreno de las aplicaciones, se disenaron y realizaron diferentes aplicaciones de sensores basadas en FBAR, siendo el detector de masas localizadas la mas relevante de entre ellas. Es de anotar que esta aplicacion fue demostrada por primera vez utilizando FBARs de alta frecuencia como elemento sensor. De tal forma, se contrastaron los resultados experimentales y de modelado del sensor. Por otra parte, se presenta tambien el concepto de sensores mecanicos basados en FBAR. Para ello se han desarrollado dos ejemplos: el acelerometro basado en FBAR y el sensor de fuerza para aplicaciones de puntas de AFM. Se reporta tambien en esta tesis la fabricacion y caracterizacion de un nuevo tipo de resonadores acusticos de AlN sin contacto entre electrodos.
Factors Influencing the DNA Nuclease Activity of Iron, Cobalt, Nickel, and Copper Chelates (2011)

A library of complexes that included iron, cobalt, nickel, and copper chelates of cyclam, cyclen, DOTA, DTPA, EDTA, tripeptide GGH, tetrapeptide KGHK, NTA, and TACN was evaluated for DNA nuclease activity, ascorbate consumption, superoxide and hydroxyl radical generation, and reduction potential under physiologically relevant conditions. Plasmid DNA cleavage rates demonstrated by combinations of each complex and biological co-reactants were quantified by gel electrophoresis, yielding second-order rate constants for DNA(supercoiled) to DNA(nicked) conversion up to 2.5 × 10(6) M(-1) min(-1), and for DNA(nicked) to DNA(linear) up to 7 × 10(5) M(-1) min(-1). Relative rates of radical generation and characterization of radical species were determined by reaction with the fluorescent radical probes TEMPO-9-AC and rhodamine B. Ascorbate turnover rate constants ranging from 3 × 10(-4) to 0.13 min(-1) were determined, although many complexes demonstrated no measurable activity. Inhibition and Freifelder-Trumbo analysis of DNA cleavage supported concerted cleavage of dsDNA by a metal-associated reactive oxygen species (ROS) in the case of Cu(2+)(aq), Cu-KGHK, Co-KGHK, and Cu-NTA and stepwise cleavage for Fe(2+)(aq), Cu-cyclam, Cu-cyclen, Co-cyclen, Cu-EDTA, Ni-EDTA, Co-EDTA, Cu-GGH, and Co-NTA. Reduction potentials varied over the range from -362 to +1111 mV versus NHE, and complexes demonstrated optimal catalytic activity in the range of the physiological redox co-reactants ascorbate and peroxide (-66 to +380 mV).
Antibacterial activity of norfloxacin (1983)

Norfloxacin, a new quinoline derivative, was studied in vitro, and determinations of agar dilution minimal inhibitory concentrations (MICs) and broth dilution MICs and MBCs were made. Nalidixic acid and cinoxacin were used as comparative agents. Norfloxacin was found to be extremely active against all strains tested of Escherichia coli, Klebsiella spp., Proteus mirabilis, indole-positive Proteus spp. Serratia spp., Citrobacter spp., and Enterobacter spp., with MICs normally below 1 microgram/ml. It also was found to be highly active against Pseudomonas aeruginosa, Staphylococcus saprophyticus, and enterococci, which are all resistant to nalidixic acid and cinoxacin. The MICs for norfloxacin obtained by broth dilution were slightly higher than those obtained by agar dilution, whereas the reverse was true for nalidixic acid and cinoxacin. The MBCs of norfloxacin were only slightly higher than the MICs, even at high inocula. The in vitro activity of norfloxacin was not dependent on the inoculum size, whereas both the MICs and the MBCs of nalidixic acid increased markedly for many of the strains tested when the inoculum was increased in broth dilution from 10(3) to 10(6) colony-forming units per ml. Norfloxacin seems to be a promising antibacterial agent for the treatment of urinary tract infections, especially those caused by Pseudomonas spp. and other species today requiring the use of injectable antibiotics.
Age‐dependent effects of hippocampal neurogenesis suppression on spatial learning (2012)

Reducing hippocampal neurogenesis sometimes, but not always, disrupts hippocampus-dependent learning and memory. Here, we tested whether animal age, which regulates rate of hippocampal neurogenesis, is a factor that influences whether deficits in spatial learning are observed after reduction of neurogenesis. We found that suppressing the generation of new hippocampal neurons via treatment with temozolomide, an antiproliferation agent, impaired learning the location of a hidden platform in the water maze in juvenile mice (1-2 months old) but not in adult mice (2-3 months old) or middle-aged mice (11-12 months old). These findings suggest that during juvenility, suppression of neurogenesis may alter hippocampal development, whereas during adulthood and aging, pre-existing neurons may compensate for the lack of new hippocampal neurons.
An overview of the Artificial Neural System and Possibility of Its Use in the Paper Industry. (1992)

Artificial neural systems, also called neural networks, and neurocomputers, were spotlighted in Japan's recent announcement of their Sixth Generation project. This paper reviews these new systems involving the back-propagation algorithms and the adaptive resonance theory. Most of