gebhart/patrepeval huggingface dataset:
The Medusa applications environment (1994)

Medusa is a peer to peer architecture for controlling networked multimedia devices. This paper describes the software model presented to the applications programmer. Active objects called modules are used to represent cameras, displays, format converters and so on. Data can flow from module to module on connections between them. We introduce two key ideas: firstly, connections between modules are simple, reliable and unbuffered. More complex connections are represented by special intermediate modules. Secondly, security is provided by naming modules with unforgeable capabilities then using hierarchies of proxy modules to restrict access.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Heart Failure with Preserved Ejection Fraction: Clinical Characteristics of 4133 Patients Enrolled in the I-PRESERVE Trial (2008)

Patients in I-PRESERVE are broadly representative of those seen in epidemiological studies and, because of this, the results of this trial should be generally applicable to "real world" patients with heart failure and preserved ejection fraction.
Modelling cascades over time in microblogs (2015)

One of the most important features of microblogging services such as Twitter is how easy it is to re-share a piece of information across the network through various user connections, forming what we call a "cascade". Business applications such as viral marketing have driven a tremendous amount of research effort predicting whether a certain cascade will go viral. Yet the rarity of viral cascades in real data poses a challenge to all existing prediction methods. One solution is to simulate cascades that well fit the real viral ones, which requires our ability to tell how a certain cascade grows over time. In this paper, we build a general time-aware cascade model for each particular cascade, in which the chance of one user's re-sharing behaviour over time is modelled as a hazard function of time. Based on two key observations on user retweeting behaviour, we design an appropriate hazard function specifically for Twitter network. We evaluate our model on a large real Twitter dataset with over two million retweeting cascades. Our experiment results show our proposed model outperforms other baseline models in terms of model fitting. Further, we make use of our model to simulate viral cascades, which are otherwise few and far in-between, to alleviate the imbalance issue in cascade data, offering a 20% boost in viral cascade discovery.
factors for survival in refractory anaemia with ring sideroblasts and marked thrombocytosis (2013)

Refractory anaemia with ring sideroblasts (RARS) and marked thrombocytosis (RARS-T) is a provisional entity in the World Health Organisation 2008 classification and has previously been shown to have a high proportion of JAK2 V617F (Janus Kinase 2) and SF3B1 (Splicing Factor 3B subunit 1) mutations. The purpose of the present study was to analyse the frequency of SF3B1 mutations in a large cohort of 111 patients with RARS-T and 33 patients with RARS and to explore the prognostic impact of SF3B1 mutational status on RARS-T. The frequency of SF3B1 mutations in RARS-T (96/111, 86.5%) and RARS (28/33, 84.8%) was similar. In RARS-T, median survival was better in SF3B1-mutated patients than in SF3B1-non-mutated patients (6.9 and 3.3 years, respectively, P ¼ 0.003). RARS can be differentiated from RARS-T by the frequency of JAK2 V617F (0% vs 48.6%). In RARS-T patients, SF3B1 (P ¼ 0.021) and JAK2 mutations (P ¼ 0.016) were independent factors for a better prognosis. Altogether, our results confirm that RARS-T is an independent entity that should be recognised by the next World Health Organisation classification. The assessment of SF3B1 mutations is of prognostic interest in RARS-T patients. Younger age, JAK2 V617F and SF3B1 mutations are the main predicting factors for survival in RARS-T.
Signal classification based on frequency analysis using multilayer neural network with limited data and computation (2002)

Signal classification performance using both multilayer neural network (MLNN) and conventional signal processing methods are theoretically compared under a limited observation period and computational load. Signals with N samples are classified based on the frequency components. A comparison is carried out based on the degree of freedom of the signal detection regions in an N-dimensional signal space. As a result, the MLNN has a higher degree of freedom, and can provide a more flexible performance for classifying the signals than the conventional methods. This analysis is further investigated through computer simulations. Multi-frequency signals and a real application in dial tone receiver, are considered. As a result, the MLNN can provide a much higher accuracy than the conventional signal processing methods.
Shining Light into Black Boxes (2012)

Funders, publishers, and research institutions must act to ensure that research computer code is made widely available.
THREE NEW ECLIPSING WHITE-DWARF-M-DWARF BINARIES DISCOVERED IN A SEARCH FOR TRANSITING PLANETS AROUND M-DWARFS (2012)

We present three new eclipsing white-dwarf/M-dwarf binary systems discovered during a search for transiting planets around M-dwarfs. Unlike most known eclipsing systems of this type, the optical and infrared emission is dominated by the M-dwarf components, and the systems have optical colors and discovery light curves consistent with being Jupiter-radius transiting planets around early M-dwarfs. We detail the PTF/M-dwarf transiting planet survey, part of the Palomar Transient Factory (PTF). We present a graphics processing unit (GPU)-based box-least-squares search for transits that runs approximately 8 × faster than similar algorithms implemented on general purpose systems. For the discovered systems, we decompose low-resolution spectra of the systems into white-dwarf and M-dwarf components, and use radial velocity measurements and cooling models to estimate masses and radii for the white dwarfs. The systems are compact, with periods between 0.35 and 0.45 days and semimajor axes of approximately 2 R_☉ (0.01 AU). The M-dwarfs have masses of approximately 0.35 M_☉, and the white dwarfs have hydrogen-rich atmospheres with temperatures of around 8000 K and have masses of approximately 0.5 M_☉. We use the Robo-AO laser guide star adaptive optics system to tentatively identify one of the objects as a triple system. We also use high-cadence photometry to put an upper limit on the white-dwarf radius of 0.025 R_☉ (95% confidence) in one of the systems. Accounting for our detection efficiency and geometric factors, we estimate that 0.08%^(+0.10%)_(-0.05%) (90% confidence) of M-dwarfs are in these short-period, post-common-envelope white-dwarf/M-dwarf binaries where the optical light is dominated by the M-dwarf. The lack of detections at shorter periods, despite near-100% detection efficiency for such systems, suggests that binaries including these relatively low-temperature white dwarfs are preferentially found at relatively large orbital radii. Similar eclipsing binary systems can have arbitrarily small eclipse depths in red bands and generate plausible small-planet-transit light curves. As such, these systems are a source of false positives for M-dwarf transiting planet searches. We present several ways to rapidly distinguish these binaries from transiting planet systems.
A SINGLE CHIP MPEGI DECODER (1995)

1. Abstract A single chip MPEGl decoder was developed. It contains MPEGI video/audio/system decoders and also include a CD-ROM decoder for package media application. The outstanding feature of the chip is its high quality control of MPEGI system such as buffer management and AV synchronization. The chip basically decodes a MPEG1 stream automatically without a support of an external microprocessor. The circuit was designed using dedicated hardwired logic resulting in a low cost and low power chip.
RF micromachined varactors with wide tuning range (2002)

Polysilicon surface micromachined varactors using two- and three-plate structures with 1.5:1 and 1.87:1 tuning ranges, respectively, are presented. The tuning ranges are near-theoretical limits and can be obtained within 4.4 V control voltage. The two-plate varactor has a nominal capacitance of 2.05 pF and a Q-factor of 20 at 1 GHz.
Mucosal IgG Levels Correlate Better with Respiratory Syncytial Virus Load and Inflammation than Plasma IgG Levels (2015)

Maternal vaccination is currently considered a strategy against respiratory syncytial virus (RSV) infections. In RSV-infected infants, high mucosal IgG levels correlated better with reduced RSV load and lower mucosal CXCL10 levels than plasma IgG levels. For future vaccination strategies against RSV, more focus should be on the mucosal humoral immune response.
Summary and Conclusions (2018)

We have tried to show in this monograph how and why keeping track of current values, on assets and on liabilities, is absolutely essential for managers who must make decisions - on investment and choice of products and lines of activity, on choosing optimal prices and outputs for the different products fashioned and sold, on choosing which combination of inputs is most cost effective, and on choosing how to finance the various activities undertaken at different points in time. Decisions can, for the most part, be formulated in a way that Current Cost/Constant Dollar Accounting data can accommodate. Budgets can be formulated in these terms, and then as events occur, the expectations embodied in budgets can be evaluated. And in a way that certainly contributes at least indirectly to the decision-making process. The framework allows both managers and interested outsiders to judge the performance of managers in a way that is very much more meaningful than alternative frameworks that are common - specifically traditional Historical Cost Accounting, and Cash Flow Accounting which some would use to replace Historical Cost Accounting because of the tremendous arbitrary allocations inevitably exercised in the traditional framework. No allocations are required in the computation of Current Real Entity Income and its principal components, Current Operating Income and Realizable Real Cost Savings and Holding Gains. Nor is any required to move from Current Real Entity Income to Current Real Ownership Income by taking out of Entity Income all of the elements associated with creditor equities, viz. Current Interest Charges and any Realizable Holding Gain or Loss on Bonds Payable.
Flexible screen printed thick film thermoelectric generator with reduced material resistivity (2014)

This work presents a flexible thick-film Bismuth Tellurium/Antimony Tellurium (BiTe/SbTe) thermoelectric generator (TEG) with reduced material resistivity fabricated by screen printing technology. Cold isostatic pressing (CIP) was introduced to lower the resistivity of the printed thermoelectric materials. The Seebeck coefficient (alpha) and the resistivity (rho) of printed materials were measured as a function of applied pressure. A prototype TEG with 8 thermocouples was fabricated on flexible polyimide substrate. The dimension of a single printed element was 20 mm × 2 mm × 78.4 µm. The coiled-up prototype produced a voltage of 36.4 mV and a maximum power of 40.3 nW from a temperature gradient of 20 °C.
Mutations in the C‐terminal domain of ALSV (Avian Leukemia and Sarcoma Viruses) integrase alter the concerted DNA integration process <i>in vitro</i> (2003)

Integrase (IN) is the retroviral enzyme responsible for the integration of the DNA copy of the retroviral genome into the host cell DNA. The C-terminal domain of IN is involved in DNA binding and enzyme multimerization. We previously performed single amino acid substitutions in the C-terminal domain of the avian leukemia and sarcoma viruses (ALSV) IN. Here, we modelled these IN mutants and analysed their ability to mediate concerted DNA integration (in an in vitro assay) as well as to form dimers (by size exclusion chromatography and protein-protein cross-linking). Mutations of residues located at the dimer interface (V239, L240, Y246, V257 and K266) have the greatest effects on the activity of the IN. Among them: (a) the L240A mutation resulted in a decrease of integration efficiency that was concomitant with a decrease of IN dimerization; (b) the V239A, V249A and K266A mutants preferentially mediated non-concerted DNA integration rather than concerted DNA integration although they were found as dimers. Other mutations (V260E and Y246W/DeltaC25) highlight the role of the C-terminal domain in the general folding of the enzyme and, hence, on its activity. This study points to the important role of residues at the IN C-terminal domain in the folding and dimerization of the enzyme as well as in the concerted DNA integration of viral DNA ends.
Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020 (2020)

Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct > 35 and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source of transmissible virus.
Development and applications of sensitive enzyme immunoassay for antibodies: A review (1989)

The sensitivity of the conventional enzyme immunoassay methods is seriously limited by the presence of nonspecific immunoglobulins at high concentrations in test serum. In order to overcome this difficulty, various methods have been developed, and the detection limit of serum antibodies has been lowered to 50-100 ng/l, which is 300,000-fold lower than that by the conventional enzyme immunoassay method using antigen-coated solid phases and anti-immunoglobulin antibody-enzyme conjugates. As a result, anti-insulin antibodies have been demonstrated in most of patients treated with insulin for 0.5-10 months, and anti-thyroglobulin IgG has been demonstrated not only in all patients with Graves' disease and chronic thyroiditis, but also in a large proportion of healthy subjects.
'Effing' the ineffable (2015)

Blockchain, an innovative public ledger of transactions that underpins digital currencies such as Bitcoin, has the potential to open up and offer radical alternatives to civic life, democracy and society. Yet there is currently only a small, technically savvy section of society who understand its principles. Therefore in order to work through and realize the potential of the blockchain and its transferability across society we need to find means to open up and reduce its 'ineffable' nature. This paper presents and reflects on an approach that made the complexity of the blockchain understandable or 'effable' using physical modeling. The design-based approach adopted a tangible system of Lego and colored stickers to allow participant-actors to physically enact transactions on a Blockchain Lego 'block'. This modeled simplification was not designed as a comprehensive or accurate explanation of Bitcoin and Blockchain but rather as a prompt for opening up rich dialogue and insightful lines of questioning.
Using simulated patients to teach family practice residents to manage patients by telephone (1987)

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Production and characterization of antibody against diacetoxyscirpenol (1984)

Antibodies against diacetoxyscirpenol (DAS) were obtained from rabbits after immunizing them with hemisuccinate or hemiglutarate derivatives of DAS conjugated to bovine serum albumin (BSA). DAS-hemiglutarate-BSA was found to be a much better immunogen than DAS-hemisuccinate-BSA. Competitive radioimmunoassay revealed that the antisera obtained from rabbits after immunization with DAS-hemiglutarate-BSA showed high specificity toward DAS. The concentrations causing 50% displacement of radioactive DAS by unlabeled DAS, 4-monoacetoxyscirpenol (MAS), and 15-MAS were found to be 1.5, 130, and 300 ng per assay, respectively. Thus, the cross-reactivities for 4-MAS and 15-MAS are ca. 87 and 300 times weaker than that of DAS. Practically no cross-reaction (less than 5% displacement) was observed when deoxynivalenol, T-2 toxin, deoxyverrucarol, and scirpentriol were tested at a concentration of 2,000 ng/ml.
[Frequency and distribution of variable-number tandem repeats in the genome of Aspergillus niculans]. (2005)

A total of 30.1 Mb of publicly available DNA sequence in Aspergillus niculans was researched for mono- to hexanucleotide variable-number tandem repeat (VNTR) to determine its type, size and frequency. A total of 4 837 VNTRs were observed in whole genomic DNA sequence with criteria of VNTR length > 15 bp and 80% matches. Considering all six classes of VNTRs, they occur on average about once every 6.2 kb for mono- to hexanucleotide in genomic DNA. The most abundance variable-number tandem repeat is pentanucleotide repeats; the number was 1 386, followed by hexanucleotide and trinucleotide repeats, the number was 1 228 and 1 199 respectively. The least abundance is dinucleotide repeat, only 144 tracts.
Tissue Sites of Aromatization in the Female Rhesus Monkey (1983)

Nine female rhesus monkeys (four in the follicular and five in the luteal phases of their cycles) had catheters implanted and were infused iv with [7-3H]androstenedione (A) and [4-14C]estrone (E1) for 4 h. Blood samples were drawn at intervals from the hepatic, renal, jugular, uterine, and brachial veins and the femoral artery. The samples were analyzed for radioactivity as A and E1. The mean +/- SE MCRs for A and E1 were 280 +/- 40 and 270 +/- 30 liters/day, respectively. The mean extractions across the liver measured in six of the monkeys were 0.83 +/- 0.03 for A and 0.71 +/- 0.06 for E1. The percentage of A entering each tissue, which was measured as E1 leaving the tissue (pA,E1AV), was 0.20 +/- 0.10 for splanchnic, 0.21 +/- 0.11 for renal, 0.46 +/- 0.21 for jugular, 2.36 +/- 1.27 for arm, and 0.35 +/- 0.10 for uterine veins. Because of the sampling technique, the value for the uterus may be a reflection of ovarian blood admixture with uterine blood. There were no apparent differences in tissue aromatization between values in the follicular and luteal phases of the cycle. The overall mean value for the percentage of A infused and measured as E1 in arterial blood (pA,E1BB) was 1.01 +/- 0.38%. Using previously reported tissue blood flow, we calculate that the contributions to the overall aromatization rate of tissues drained by the brachial, renal, jugular, hepatic, and uterine veins are 23%, 5%, 5%, 4%, and 0.2%, respectively. Thus, the splanchnic tissue is a minor site for extraglandular aromatization of androgens in the rhesus monkey. An important site appears to be the arm, which reflects aromatization in adipose tissue, muscle, skin, and supporting structures.
Top-k string similarity search with edit-distance constraints (2013)

String similarity search is a fundamental operation in many areas, such as data cleaning, information retrieval, and bioinformatics. In this paper we study the problem of top-k string similarity search with edit-distance constraints, which, given a collection of strings and a query string, returns the top-k strings with the smallest edit distances to the query string. Existing methods usually try different edit-distance thresholds and select an appropriate threshold to find top-k answers. However it is rather expensive to select an appropriate threshold. To address this problem, we propose a progressive framework by improving the traditional dynamic-programming algorithm to compute edit distance. We prune unnecessary entries in the dynamic-programming matrix and only compute those pivotal entries. We extend our techniques to support top-k similarity search. We develop a range-based method by grouping the pivotal entries to avoid duplicated computations. Experimental results show that our method achieves high performance, and significantly outperforms state-of-the-art approaches on real-world datasets.
H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells (2016)

Embryonic stem cells (ESCs) are a hallmark of ideal pluripotent stem cells. Epigenetic reprogramming of induced pluripotent stem cells (iPSCs) has not been fully accomplished. iPSC generation is similar to somatic cell nuclear transfer (SCNT) in oocytes, and this procedure can be used to generate ESCs (SCNT-ESCs), which suggests the contribution of oocyte-specific constituents. Here, we show that the mammalian oocyte-specific linker histone H1foo has beneficial effects on iPSC generation. Induction of H1foo with Oct4, Sox2, and Klf4 significantly enhanced the efficiency of iPSC generation. H1foo promoted in vitro differentiation characteristics with low heterogeneity in iPSCs. H1foo enhanced the generation of germline-competent chimeric mice from iPSCs in a manner similar to that for ESCs. These findings indicate that H1foo contributes to the generation of higher-quality iPSCs.
The Use of Video to Put Interaction at the Centre of Supporting Parents Communication with Children (2013)

AbstractTwo student primary health care professional groups were brought together for two days of training to look at their role and skills in reinforcing and supporting parents in facilitating children’s communication development through interaction. Student Speech and Language Therapists (SLT) and student Specialist Community Public Health Nurses (SCPHN) were introduced to the practice of video interaction as a tool and shown how it could be used with families. The use of video as a powerful tool for reflecting on communication and interaction skills in student professionals also has potential application for other groups. This approach to working with families has wide relevance for educationalists engaged in teaching professional practitioners through reflective and reflexive processes.