gebhart/patrepeval huggingface dataset:
Nicotine receptors in the mammalian brain (1990)

Nicotine is a drug of abuse that presumably exerts its psychoactive effect through its interactions with nicotine binding sites in the central nervous system. Among its potential sites of action are the neuronal nicotinic acetylcholine receptors and the neuronal alpha-bungarotoxin binding sites. In this review we focus on the neuronal nicotinic acetylcholine receptors, their diversity, distribution, and functions as nicotine receptors or as mediators of synaptic transmission in the mammalian brain. We find that the complexity characteristic of the gene family encoding the subunits of these receptors is reflected both in the pattern of expression of the genes and in the pharmacological diversity of the expressed receptors.
Quality Improvement Principles in Practice: The Reduction of Umbilical Cord Blood Errors in the Labor and Delivery Suite (1998)

Mislabeled umbilical cord blood specimens were identified as an important and difficult problem to solve. Quality improvement principles were employed after education-based interventions failed to achieve measurable improvement. A small interdisciplinary working group of key stakeholders investigated, designed, and evaluated interventions for a solution. This article describes a system-based change where substantial qualitative and quantitative improvements were measured. The success of the change is attributed to the involvement and commitment by key stakeholders and use of systems reengineering principles.
The Proper Protocol: Validity and Completeness of Verbal Reports (1994)

It is a fact that I see an inkstand before me; but before I can say that I am obliged to have impressions of sense into which no idea of an inkstand, or of any separate object, or of an I, or of seeing, enter at all; and it is true that my judging that I see an inkstand before me is the product of mental operations upon these impressions of sense. (Peirce, 1901, cited in Bowers; Regehr, Balthazard, & Parker, 1990, p. 94)
Economic impacts of leafy spurge on grazing lands in the northern Great Plains (1991)

Leafy spurge (Euphorbia esula) is an exotic, noxious perennial weed that has become widely distributed in the northern Great Plains. The plant is found primarily in nontilled agricultural land (pasture, rangeland, hayland, and idle cropland) and also in road ditches, around lakes, and in parks. Because leafy spurge exhibits exceptional ability to spread and thrive in a variety of habitats, is hardy, and resists control, it has become a serious problem for farmers and ranchers.
Down regulation of poliovirus receptor RNA in HeLa cells resistant to poliovirus infection (1991)

A line of HeLa cells (SOFIA) was previously isolated that is resistant to poliovirus infection and does not express functional virus binding sites at the cell surface. The expression of the poliovirus receptor (PVR) gene in SOFIA cells was examined to determine the molecular basis for the failure of these cells to express PVRs. Southern blot analysis of genomic DNA revealed that the PVR gene in SOFIA cells did not contain gross alterations. However, PVR transcripts were not detected in Northern (RNA) blot analysis of SOFIA cell RNA. In vitro nuclear run-on analysis showed that transcription of PVR-specific RNA was reduced in SOFIA cells. Treatment of SOFIA cells with 5-azacytidine restored susceptibility to poliovirus infection, which correlated with the appearance of PVRs at the cell surface, as detected with anti-PVR monoclonal antibody D171. PVR RNA was detected in clones derived from 5-azacytidine-treated SOFIA cells. SOFIA cells were converted to poliovirus sensitivity at a rate of 5 to 7%, suggesting that down regulation of PVR expression involved few cellular targets. Resistance of SOFIA cells to poliovirus infection therefore appears to result from down regulation of PVR RNA, leading to lack of PVR expression at the cell surface. Methylation may play a role in regulating the expression of the PVR gene, which is not essential for survival of HeLa cells.
Widespread Worry and the Stock Market (2010)

Our emotional state influences our choices. Research on how it happens usually comes from the lab. We know relatively little about how real world emotions affect real world settings, like financial markets. Here, we demonstrate that estimating emotions from weblogs provides novel information about future stock market prices. That is, it provides information not already apparent from market data. Specifically, we estimate anxiety, worry and fear from a dataset of over 20 million posts made on the site LiveJournal. Using a Granger-causal framework, we find that increases in expressions of anxiety, evidenced by computationally-identified linguistic features, predict downward pressure on the S&P 500 index. We also present a confirmation of this result via Monte Carlo simulation. The findings show how the mood of millions in a large online community, even one that primarily discusses daily life, can anticipate changes in a seemingly unrelated system. Beyond this, the results suggest new ways to gauge public opinion and predict its impact.
Carbohydrate recognition molecules on lymphocytes (1992)

Conference Article| May 01 1992 Carbohydrate recognition molecules on lymphocytes Christopher R. Parish; Christopher R. Parish 1Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra ACT. 2601, Australia Search for other works by this author on: This Site PubMed Google Scholar Meredith G. Bradbury; Meredith G. Bradbury 1Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra ACT. 2601, Australia Search for other works by this author on: This Site PubMed Google Scholar Susan A. Weston; Susan A. Weston 1Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra ACT. 2601, Australia Search for other works by this author on: This Site PubMed Google Scholar Hilary S. Warren Hilary S. Warren *Cancer Research Unit, Woden Valley Hospital, Woden ACT. 2606, Australia Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: December 18 1991 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1992 Biochemical Society1992 Biochem Soc Trans (1992) 20 (2): 295–297. https://doi.org/10.1042/bst0200295 Article history Received: December 18 1991 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Christopher R. Parish, Meredith G. Bradbury, Susan A. Weston, Hilary S. Warren; Carbohydrate recognition molecules on lymphocytes. Biochem Soc Trans 1 May 1992; 20 (2): 295–297. doi: https://doi.org/10.1042/bst0200295 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: HKV, high endothelial venules, SP, sulphated polysaccharide, GAG, glycosaminoglycans, MHC, major histocompatibility complex, SSC, splenic sinusoidal cells, LFA-1, lymphocyte function-associated antigen-1 This content is only available as a PDF. © 1992 Biochemical Society1992 Article PDF first page preview Close Modal You do not currently have access to this content.
QUANTUM ELECTRONICS III. VOLUME 1. (1964)

Contents: Solid state lasers; Lasers modes and special techniques; Non-linear optics; Semiconductor and phonon masers.
Synergistic inhibition of T-lymphoblastic leukemic CCRF-CEM cell growth by gallium and recombinant human alpha-interferon through action on cellular iron uptake. (1994)

Gallium, a metal with clinical antineoplastic activity, is known to inhibit cellular iron uptake and iron-dependent DNA synthesis. Little information exists regarding the efficacy of gallium in combination with other agents. Since alpha-interferon (IFN-alpha) can modulate the action of certain chemotherapeutic drugs, we examined its influence on the growth inhibitory effects of gallium in CCRF-CEM cells. IFN-alpha and gallium as single agents had only minimal to moderate antiproliferative effects. In combination, however, both drugs synergistically inhibited cell growth, causing cell death accompanied by DNA fragmentation. At lower concentrations (120 microM), gallium inhibited cellular iron uptake but did not increase transferrin receptor expression, nor did it block cellular proliferation. The addition of IFN-alpha to this concentration of gallium significantly increased the gallium-induced block of iron uptake, resulting in an increase in transferrin receptors and an inhibition of cell growth. In contrast, IFN-alpha did not enhance the effects of the iron chelator deferoxamine on iron uptake or cell growth. Our studies suggest that gallium and IFN-alpha synergistically inhibit DNA synthesis through a mechanism that includes inhibition of cellular iron uptake and depletion of intracellular iron below the critical level needed to maintain DNA synthesis.
M-ary trellis coded FSK for narrowband, low error-rate applications (2003)

This paper describes an optimum trellis-coded M-ary frequency-shift-keying (FSK) signaling technique. The trellis code is derived and its spectrum and error rate presented. A computer simulation of the trellis-coded FM modem is performed to access performance to verify the analytically predicted performance under conditions not readily analyzed mathematically (such as fading and dispersion) and to study implementation tradeoffs. The effect of shaped data, IF filtering, and adjacent channel interference on the error rate is also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Epitaxial lift-off of GaAs thin-film solar cells followed by substrate reuse (2012)

We demonstrate the fabrication of GaAs thin-film solar cells on plastic substrate by combining epitaxial lift-off (ELO) and cold weld bonding. A lattice-matched epitaxial protection layer is employed to preserve the wafer surface during the ELO process to enable multiple reuses of the parent wafer. For the removal of protection layer and contaminants from ELO process, we have developed a unique pre-cleaning process. Combination of these technologies enables 1) the fabrication of light weight, flexible thin-film GaAs solar cells, 2) a transfer process that cold-weld bonds the GaAs epi-cell onto an accepting plastic foil substrate, and 3) the multiple growths from a single parent substrate the requires no destructive mechanical polishing process. The morphology and chemistry of the GaAs substrate surface after ELO simulation and protection-layer removal are compared to those of the original substrate using atomic force microscopy, energy dispersive spectrometry, X-ray photoelectron spectrometry and reflection high energy electron diffraction. The regrown epitaxial film quality is investigated by Hall-effect and photoluminescence measurements, and cross-sectional transmission electron microscopy. We show that p-n junction GaAs solar cells grown on original and reused wafers have power conversion efficiencies of ~23%, under simulated AM1.5G illumination. The ability to perform multiple growths from a single parent wafer promises to dramatically reduce production costs for high power conversion efficiency GaAs solar cells.
New Frac Fluid Provides Excellent Proppant Transport and High Conductivity (2009)

Abstract A new clean biopolymer-based fracturing fluid has been developed. The new fluid has high conductivity, stable viscosity, low pipe friction, excellent proppant transport, and the capability to be used with produced water. This fluid-system development effort was aided by the evolution of a new approach to proppant transport measurement as well as the operational deployment of a dry-polymer blender used to effectively hydrate the fluid system as part of an on-the-fly treatment. The new fluid has been field-trialed in 14 frac stages over four wells with about two million pounds of proppant placed. The application of the new fluid and experience of the field-trials are discussed. This new clean fluid is widely applicable to fracturing low-permeability reservoirs worldwide and can be used where both waterfrac and traditional gelled fluids are currently used. This fluid signals a dramatic shift in fracturing low-permeability unconventional reservoirs by coupling excellent proppant transport with high conductivity.
Cluster-Based Landmark and Event Detection for Tagged Photo Collections (2010)

An image analysis scheme can automate the detection of landmarks and events in large image collections, significantly improving the content-consumption experience.
In vitro interactions between a potyvirus-encoded, genome-linked protein and RNA-dependent RNA polymerase. (1998)

Recent studies have shown that potyvirus VPg/ proteinases and RNA-dependent RNA polymerases are capable of protein-protein interactions in yeast cells. We have extended these studies in vitro. We found that tobacco vein mottling virus (TVMV) VPg is retained on glutathione-Sepharose matrices if co-incubated with a glutathione S-transferase (GST)-NIb fusion protein, but not with GST, which is suggestive of a direct physical interaction between these two proteins. However, a mutation in the VPg (Y1860S) that eliminates virus infectivity and the interaction in yeast cells had little effect on the in vitro interaction. We also found that the TVMV VPg and NIa proteins are capable of stimulating the polymerase activity of the NIb protein. Since this stimulatory activity is retained when the proteinase domain of the NIa is removed, we conclude that the VPg is the moiety responsible for the stimulation of polymerase activity. As with the interaction revealed by co-purification, the Y1860S mutation had little or no effect on the stimulation of polymerase activity. Moreover, the VPg was able to stimulate a mutant NIb with an altered 'GDD' motif. Our studies thus provide two lines of evidence indicative of in vitro interactions between the TVMV VPg and NIb proteins.
Intracellular Calcium Homeostasis in a Human Neuroblastoma Cell Line: Modulation by Depolarization, Cholinergic Receptors, and α‐Latrotoxin (1988)

Intracellular calcium homeostasis and its modulation by different agents was studied in control and differentiated IMR32 human neuroblastoma cells by using the Ca2+-sensitive fluorescent dye quin2. The results obtained demonstrate the existence in IMR32 cells of (a) voltage-dependent, verapamil sensitive, Ca2+ channels, which are expressed before differentiation; (b) muscarinic receptors whose activation triggers both Ca2+ influx and Ca2+ redistribution from intracellular stores, whereas nicotinic receptors and alpha-bungarotoxin binding sites do not; and (c) receptors for alpha-latrotoxin (the major toxin of the black widow spider venom), which are well-known markers of the neuronal presynaptic membrane. Up to now, no cell lines of human origin sensitive to this toxin have been identified. These results confirm that IMR32 cells are very convenient model cells for studying specific aspects of the neurochemistry and neurobiology of the human neuron at the molecular and cellular levels.
State re-encoding for peak current minimization (2006)

In a synchronous finite state machine (FSM), huge current peaks are often observed at the moment of state transition. Previous low power state encoding algorithms focus on the reduction of switching activities of state registers (i.e., state bits). However, even though the switching state registers are the same, different combinations of switching directions still result in different peak currents. Based on that observation, in this paper, we propose the first approach to re-encode an FSM by considering the switching directions of state registers in order to minimize the peak current caused by the state transition. Experimental data consistently show that the peak current is reduced with no penalty.
Measurements of the three-dimensional impurity profile in Si using chemical etching and scanning tunneling microscopy (1991)

Three-dimensional boron impurity concentration profiles in silicon substrates have been measured with 10 nm resolution by scanning tunneling microscopy (STM) on chemically etched cleaved silicon surfaces using an impurity sensitive HF-HNO3-H2O solution. Comparisons to depth profiles obtained with secondary-ion mass spectroscopy and spreading resistance methods reveal that our proposed method measures activated boron impurity concentration rather than total boron concentration. Three-dimensional impurity profiling is demonstrated with a metal-oxide-silicon structure, and the lateral junction depth in the test structure is found to be 70% of the junction depth.
Congenital Short QT Syndrome (2016)

Congenital short QT syndrome (SQTS) is characterised by extremely short QT intervals, typically with QTc less than 330 ms and a propensity for life threatening ventricular arrhythmias and atrial fibrillation. The QT interval in SQTS does not change significantly with heart rate and the T waves have a narrow base and high voltage, similar to those in hyperkalemia.
Charging and behavior of a spherically conducting particle on a dielectrically coated electrode in the presence of electrical gradient force in atmospheric air (2002)

This paper discusses the charging and behavior of a spherically conducting particle on a dielectrically coated electrode in non-uniform dc and ac electric fields between non-parallel plane electrodes in atmospheric air. The charging mechanism of a particle resting on a dielectrically coated electrode is investigated by observing light emissions from partial discharges and by utilizing the dust figure technique. The charge acquired by a particle is estimated from the results of particle motion onset voltage measurement and direct measurement with a Faraday cage. The basic particle movement as well as particle-triggered breakdown characteristics under non-uniform electric field distribution along the electrode surface is also investigated. The results suggest that the effect of the electrical gradient force/dielectro-phoretic force on particle motion on a dielectrically coated electrode should be adequately considered in the design of gas insulated systems (GIS). This is because a particle can move laterally on the coated electrode toward increasing electric field regions by the action of the electrical gradient force which is independent of the charge on the particle. Also the possibility of the particle charging and lifting at high field regions or reaching and adhering onto an insulating spacer further increases the risk of breakdown.
The theory of solution hardening (1977)

Abstract The glide plane of a dislocation contains a concentration c of obstacles, which we take to be attractive potential wells each made of four parabolic arcs of width w, exerting a maximum attractive force fm. If the line tension of the dislocation is T, the nature of its motion is controlled by the parameter β = f m/4Tcw 2. When β is large the motion occurs in the Friedel limit. A length of dislocation line interacting with three consecutive obstacles A, B, C breaks away from B and moves until it interacts with a fourth obstacle D. The portions of dislocation line outside the segment AC do not move appreciably during this process. If the Burgers vector of the dislocation is 6, the critical resolved shear stress τc is given in this limit by bτc = (f m 3c/2T)1/2. In the Labusch limit, where β is small, we find, in agreement with Labusch, that the motion of a dislocation segment through a well is then adiabatic and non-dissipative. The segment of dislocation which moves coherently is in contact with many obstacles. Labusch assumes that the obstacles are statistically aggregated into clusters, and shows that, if the clusters are large enough, one obtains a flow stress roughly β−1/6 times that predicted by Friedel. We believe that his argument is not self-consistent, because the dislocation then interacts coherently with only three consecutive clusters. By using an earlier statistical idea, due to Mott, and applying it to a simple model due to Lowell, we give an analysis which clarifies the physical processes occurring. While the advance of a segment of dislocation which is interacting with a large number n of obstacles is reversible, it does not occur under zero force, but under a force of order ± n 1/2/m. In regions where this force opposes the motion of the dislocation, it determines the flow stress; in regions where this force aids the motion, both this force and the force on the dislocation produced by the external stress lead to an acceleration of the dislocation and hence to dissipation.
Computed Tomographic-Based Volumetric Reconstruction of the Pulmonary System in Scoliosis (2007)

CT-based volumetric reconstruction of the pulmonary system in scoliosis patients shows differences in both lung volumes and lung volume ratios compared with normal controls.
2-(2'-Hydroxyphenyl)-4-aryl-1,5-benzodiazepines as CNS active agents. (1982)

1-Aryl-3(2'-hydroxyphenyl)-propane-1,3-diones (III) have been prepared by the Baker-Venkataraman transformation of the corresponding 2-substituted benzoyl-oxyacetophenones (II). The aforesaid propane-1,3-diones (III) were condensed with o-phenylene diamine to give eight benzodiazepines (IV) which have been found to be very good MAO inhibitors (in vitro), and anticonvulsant and hypnotic (in vivo) agents. Some chemical leads on pharmacological activities have been observed.
FDDI- A LAN among MANS (1990)

FDDI (Fiber Distributed Data Interface) is a 100 Mbit/sec local area network (LAN) based on a token ring protocol operating over an optical fiber medium. Though not a metropolitan area network (MAN), FDDI can operate over distances normally considered as the province of MANs. With the addition of FDDI-II capabilities, and the newly defined mapping for FDDI over SONET, FDDI now offers MAN functionality for large organizations needing to provide integrated services over a widely based high performance private network. This paper updates earlier efforts on this subject, giving an up-to-date overview of FDDI, FDDI-II and SONET mapping. At the end of the paper a brief look at the possible future for FDDI technology is given.
Synthesis of High Purity Yb <sup>3+</sup> ‐Doped Lu <sub>2</sub> O <sub>3</sub> Powder for High Power Solid‐State Lasers (2011)

We have synthesized high‐purity Yb 3+ ‐doped Lu 2 O 3 powder by the coprecipitation method. We have demonstrated that the recrystallization of the metal nitrates greatly improve the chemical purity of the resulting oxides. From thermogravimetry and differential thermal analysis study, we have calculated the approximate formula of the oxinitrate precipitate precursor as Lu 1.8 Yb 0.2 (OH) 5.44 (NO 3 ) 0.56 ·0.58H 2 O. Fine and soft agglomerate powders were obtained after calcinations. We have shown that the powder is mainly in the form of polycrystalline soft agglomerates composed with 15–20 nm size crystals. The resulting ceramic showed higher transparency (close to theoretical limit) compared with the ones fabricated with commercial powders.
Effect of different probiotic preparations on anti-Helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study (2002)

All the probiotics used were superior to placebo for side effect prevention, but were not associated with better compliance with antibiotic therapy. The effect of probiotic supplementation on side effects during anti-H. pylori regimens seemed to be independent of the probiotic species used.