gebhart/patrepeval huggingface dataset:
ONLINE COLLABORATION IMPACT ON STUDENT ENGAGEMENT AND COMMUNICATION IN ENVIRONMENTAL SCIENCE (2013)

To enhance student engagement in Environmental Science enlightening articles and applicable case studies were integrated in the science content. For each unit students read articles, responded to essential questions, and participated in an online discussion forum with their peers. This study focused on the benefit of online collaboration to promote independence in learning, engagement in the content, self-direction and communication among ninth grade students.
Concurrent Detection of Cellular and Molecular Cancer Markers Using an Immunomagnetic Flow System (2015)

We report a detection system for simultaneous measurement of cellular and molecular markers of cancer. Magnetic beads conjugated with antibodies against a specific antigen are used to capture both free molecules and whole cells overexpressing the antigen. The target-bound beads then flow through a microfluidic chamber where they are drawn to a glass surface by an external magnetic field. The cells and molecules captured on the surface are quantitatively analyzed using fluorescent microscopy. The system was characterized by detecting free folate receptor (FR) and an FR+ cancer cell line (KB) in culture media. The system detected as low as 10 pM of FR and captured 87% of the spiked KB cells at a volumetric throughput of 3 mL/min. We further demonstrated the detection of 100 KB cells and 200 pM FR spiked into healthy human blood to simulate detection of rare cells and protein biomarkers present in a cancer patient's blood sample. The FR concentration was measured to be 244 pM (including the intrinsic FR present in the blood), and the total number of KB cells in the sample was estimated to be 98. The potential of this approach in clinical diagnostics was also demonstrated by detecting both FR+ cells and free FR in an ascites sample obtained from an ovarian cancer patient. Because of the system's capability to detect multiple targets at the same time, its high throughput, and its overall simplicity, we expect it to be highly useful in a wide range of research settings.
CRYOPRESERVATION OF EMBRYONIC AXES OF FERULA GUMMOSA: A TOOL FOR GERMPLASM CONSERVATION AND GERMINATION IMPROVEMENT (2012)

ISHS International Symposium on Medicinal and Aromatic Plants IMAPS2010 and History of Mayan Ethnopharmacology IMAPS2011 CRYOPRESERVATION OF EMBRYONIC AXES OF FERULA GUMMOSA: A TOOL FOR GERMPLASM CONSERVATION AND GERMINATION IMPROVEMENT
Development of a DNA Aptamer for Screening Neisseria meningitidis Serogroup B by Cell SELEX (2017)

The findings suggest the application of the developed aptamer in specific detection of N. meningitidis serogroup B amongst a group of meningitis causing bacteria.
Immune activation alters cellular and humoral responses to yellow fever 17D vaccine (2014)

This study was funded by Canada's Global Health Research Initiative, Defense Threat Reduction Agency, National Institute of Allergy and Infectious Diseases, Bill & Melinda Gates Foundation, and United States Agency for International Development.
Logistic regression analysis of risk factors for intra-amniotic infection. (1989)

The identification of risk factors for intra-amniotic infection may allow changes in obstetric management and reduce complications. In a pilot study, stepwise logistic regression identified duration of ruptured membranes and duration of interval monitoring as significant risk factors for intra-amniotic infection. Using the preliminary regression equation, we established critical durations (risk criteria) to predict a 20% or greater probability of intra-amniotic infection. Subsequently, 2908 patients were screened prospectively for risk criteria and/or the presence of intra-amniotic infection. Seven hundred five patients of the 2908 (24%) met the risk criteria, and 107 of 124 cases of intra-amniotic infection (86%) met the risk criteria. In patients meeting the risk criteria, the relative risk of intra-amniotic infection was 19.7. In addition, 81 of 705 (12%) of mothers developed endometritis. Ten neonates of mothers with criteria developed sepsis or pneumonia. A stepwise logistic regression performed on the prospectively gathered data showed that among patients meeting risk criteria, parity, duration of internal monitoring, and duration of membrane rupture were the significant risk factors for intra-amniotic infection.
Facile Synthesis of Defective TiO2−x Nanocrystals with High Surface Area and Tailoring Bandgap for Visible-light Photocatalysis (2015)

A facile hydrothermal approach has been developed to prepare defective TiO2-x nanocrystals using Ti(III)-salt as a precursor and L-ascorbic acid as reductant and structure direction agent. The prepared TiO2-x nanocrystals are composed of a highly crystallized TiO2 core and a disordered TiO2-x outer layer, possessing high surface area, controlled oxygen vacancy concentration and tunable bandgap via simply adjusting the amount of added L-ascorbic acid. The defective TiO2-x shows high photocatalytic efficiency in methylene blue and phenol degradation as well as in hydrogen evolution under visible light, underlining the significance of the present strategy for structural and bandgap manipulation in TiO2-based photocatalysis.
Municipal Solid Waste Bottom Ash as Portland Cement Concrete Ingredient (1998)

The disposal of municipal solid waste ash has become a significant economic and environmental issue. Municipal solid waste ash can be considered to have a fly ash and a bottom ash component. Municipal solid waste bottom ash (MSWBA) from a refuse-derived fuel facility was evaluated as a potential portland cement concrete ingredient. Portland cement–related ASTM methods and other analytical techniques such as X-ray diffraction were used. The sample MSWBA was found to be a marginal concrete aggregate. The sample MSWBA met most ASTM C 331 standards such as size gradation, but the high angularity and brittle nature of the MSWBA would significantly affect concrete workability. The MSWBA sulfate and chloride concentrations also were high enough to create potential sulfate attack and reinforcing steel corrosion problems. Iron removal and aggregate processes such as size control offer cost-effective methods to improve MSWBA for use as an aggregate.
Effects of Sleep Deprivation on Nocturnal Cytokine Concentrations in Depressed Patients and Healthy Control Subjects (2012)

Previous studies have reported alterations of cytokine and cytokine-receptor concentrations in psychiatric patient populations, including patients with major depressive disorder (MDD). However, study results are conflicting, and possible causes for these abnormalities are unknown. Since sleep deprivation may induce a rapid improvement of mood in depressed patients, the authors investigated the impact of total sleep deprivation (TSD) for one night, and subsequent recovery sleep, on nocturnal concentrations of interleukin-6 (IL-6), interleukin-1-receptor antagonist (IL-1RA), and soluble IL-2 receptor (sIL-2R) in 15 unmedicated patients with MDD and 16 healthy volunteers. Whereas IL-6 levels normalized again during the recovery night in depressed patients, they were still elevated in control subjects. Serum levels of IL-1RA were higher in depressed patients than in controls, but were not affected by TSD. During recovery sleep, IL-1RA levels increased as compared with the preceding TSD night only in controls. Responders (N=8) differed from nonresponders (N=7) to TSD with regard to IL-1RA, which increased significantly during TSD in responders only. Sleep deprivation therefore seems to significantly affect cytokine levels in both depressed patients and healthy subjects, but does so in different ways. Sleep disturbances in depressed patients could account for the increased levels of cytokines found in these patients in several previous studies. The interaction between antidepressant effects of TSD and alterations of cytokines warrants further investigation.
Analytical Computation of the Spatial Resolution in GNSS-R and Experimental Validation at L1 and L5 (2020)

Global navigation satellite systems reflectometry (GNSS-R) is a relatively novel remote sensing technique, but it can be understood as a multi-static radar using satellite navigation signals as signals of opportunity. The scattered signals over sea ice, flooded areas, and even under dense vegetation show a detectable coherent component that can be separated from the incoherent component and processed accordingly. This work derives an analytical formulation of the response of a GNSS-R instrument to a step function in the reflectivity using well-known principles of electromagnetic theory. The evaluation of the spatial resolution then requires a numerical evaluation of the proposed equations, as the width of the transition depends on the reflectivity values of two regions. However, it is found that results are fairly constant over a wide range of reflectivities, and they only vary faster for very high or very low reflectivity gradients. The predicted step response is then satisfactorily compared to airborne experimental results at L1 (1575.42 MHz) and L5 (1176.45 MHz) bands, acquired over a water reservoir south of Melbourne, in terms of width and ringing, and several examples are provided when the transition occurs from land to a rough ocean surface, where the coherent scattering component is no longer dominant.
Corticosteroid modulation of interleukin-1 hematopoietic effects and toxicity in a murine system (1994)

Interleukin-1 (IL-1) has been shown to ameliorate the hematopoietic toxicities of antitumor chemotherapeutic agents in both mice and humans. However, IL-1 toxicity in humans is considerable and is similar to the systemic inflammatory toxicities induced by IL-3, IL-6, and other cytokines with pleiotropic biologic activities, eg, fever, nausea, malaise, and hypotension. We hypothesized that corticosteroids may reduce IL-1 toxicity without reducing IL-1 hematopoietic effects in vivo. C3H/HeJ mice (female, 6 weeks) were treated for 7 days subcutaneously with cortisone acetate (CA), (0.1, 0.25, or 0.5 mg/d/mouse), intraperitoneally with IL-1 (1 or 2 micrograms/d/mouse), or both. As expected, IL-1 increased white blood cell counts, splenic granulocyte-macrophage colony-forming units, and spleen cell number, and protected mice from lethal doses of carboplatin (200 mg/kg; Paraplatin, Bristol Laboratories, Evansville, IN) administered the day after completion of the 7 days of IL-1 administration. CA did not significantly block the hematopoietic effects of IL-1 or the ability of IL-1 to protect mice from the hematopoietic toxicity of carboplatin. IL- 1 administered to mice at 8 micrograms/d/mouse for 5 days induced decreased activity, roughening of hair, diarrhea, pancytopenia, multiple metabolic abnormalities, and death in 60% of mice. IL-1 at the therapeutic doses (0.5 to 2 micrograms/d) was not toxic. CA in a dose- dependent manner blocked all of the above mentioned toxicities when administered 24 hours and 30 minutes before each IL-1 injection. CA also decreased IL-1-induced increase in plasma tumor necrosis factor levels at the time point examined.
A Stochastic Branch-and-Bound Approach to Activity Crashing in Project Management (2000)

Many applications such as project scheduling, workflow modeling, or business process re-engineering incorporate the common idea that a product, task, or service consisting of interdependent time-related activities should be produced or performed within given time limits. In real-life applications, certain measures like the use of additional manpower, the assignment of highly-skilled personnel to specific jobs, or the substitution of equipment are often considered as means of increasing the probability of meeting a due date and thus avoiding penalty costs. This paper investigates the problem of selecting, from a set of possible measures of this kind, the combination of measures that is the most cost-efficient. Assuming stochastic activity durations, the computation of the optimal combination of measures may be very expensive in terms of runtime. In this article, we introduce a powerful stochastic optimization approach to determine a set of efficient measures that crash selected activities in a stochastic activity network. Our approach modifies the conventional Stochastic Branch-and-Bound, using a heuristic—instead of exact methods—to solve the deterministic subproblem. This modification spares computational time and by doing so provides an appropriate method for solving various related applications of combinatorial stochastic optimization. A comparative computational study shows that our approach not only outperforms standard techniques but also definitely improves conventional Stochastic Branch-and-Bound.
ΤΟ ΘΕΑΤΡΟ ΤΟΥ ΠΑΡΑΛΟΓΟΥ (1976)

Το μοντέρνο δράμα, όπου γράφeται και παίζeται, ύστeρα κυρίως από τον δeύτeρο παγκόσμιο πόλeμο, στην Eυρώπη και στην Αμeρική(τeλeυταία έχeι eισβάλeι και στις δικέ μας σκηνές), παρουσιάζeι ένα μeγάλο φάσμα ιδιορρυθμιών, που αρχίζeι από ανeκτές μέσα στο παραδοσιακό πλαίσιο καινοτομίeς στη σύνθeση και στην eρμηνeία, έως τους eξωφρeνισμούς του pop. Ιδού για παράδeιγμα μια ακραία πeρίπτωση. (Αντιγράφω από άρθρο γνωστού Αμeρικάνου κριτικού) : «Τον Μάιο του 1969 ο συνθέτης Τζων Καίητζ και ο συνeργάτης του Λάχαρeν Χίλλeρ χρησιμοποίησαν μια τeράστια αίθουσα του Πανeπιστημίου του Ιλλινόι όπου έδωσαν τν πρώτη και μοναδική παράσταση της νέας τους δημιουργίας πόπ ‘Χαρπσιχορντ’. Μe όποιο πρίσμα και αν έβλeπe κανeίς τη δημιουργία eκeίνη, παρουσίαζe ασφαλώς κάτι πολύ ιδιαίτeρο. ΘEΜΑΤΙΚEΣ EΠΙΚEΦΑΛΙΔEΣ ΤEΧΝΗ-- EΛΛΑΔΑ-- ΙΣΤΟΡΙΑ ΤEΧΝΗ-- ΜEΛEΤΗ ΚΑΙ ΔΙΔΑΣΚΑΛΙΑ ΔΡΑΜΑ-- ΙΣΤΟΡΙΑ ΚΑΙ ΚΡΙΤΙΚΗ
Nanofibrous Collagen Nerve Conduits for Spinal Cord Repair (2012)

Nerve regeneration in an injured spinal cord is often restricted, contributing to the devastating outcome of neurologic impairment below the site of injury. Although implantation of tissue-engineered scaffolds has evolved as a potential treatment method, the outcomes remain sub-optimal. One possible reason may be the lack of topographical signals from these constructs to provide contact guidance to invading cells or regrowing axons. Nanofibers mimic the natural extracellular matrix architecturally and may therefore promote physiologically relevant cellular phenotypes. In this study, the potential application of electrospun collagen nanofibers (diameter=208.2±90.4 nm) for spinal cord injury (SCI) treatment was evaluated in vitro and in vivo. Primary rat astrocytes and dorsal root ganglias (DRGs) were seeded on collagen-coated glass cover slips (two-dimensional [2D] substrate controls), and randomly oriented or aligned collagen fibers to evaluate scaffold topographical effects on astrocyte behavior and neurite outgrowth, respectively. When cultured on collagen nanofibers, astrocyte proliferation and expression of glial fibrillary acidic protein (GFAP) were suppressed as compared to cells on 2D controls at days 3 (p<0.05) and 7 (p<0.01). Aligned fibers resulted in elongated astrocytes (elongation factor >4, p<0.01) and directed the orientation of neurite outgrowth from DRGs along fiber axes. In the contrast, neurites emanated radially on randomly oriented collagen fibers. By forming collagen scaffolds into spiral tubular structures, we demonstrated the feasibility of using electrospun nanofibers for the treatment of acute SCI using a rat hemi-section model. At days 10 and 30 postimplantation, extensive cellular penetration into the constructs was observed regardless of fiber orientation. However, scaffolds with aligned fibers appeared more structurally intact at day 30. ED1 immunofluorescent staining revealed macrophage invasion by day 10, which decreased significantly by day 30. Neural fiber sprouting as evaluated by neurofilament staining was observed as early as day 10. In addition, GFAP immunostained astrocytes were found only at the boundary of the lesion site, and no astrocyte accumulation was observed in the implantation area at any time point. These findings indicate the feasibility of fabricating 3D spiral constructs using electrospun collagen fibers and demonstrated the potential of these scaffolds for SCI repair.
Endothelial Dysfunction: Implications for Therapy of Cardiovascular Diseases (1998)

Endothelial dysfunction serves as a marker for cardiovascular disease, but pharmacologic treatment does not consistently restore normal endothelial function. Nevertheless, some of these agents are known to have positive clinical outcomes. Future research using these techniques will provide greater insight into the effects of many commonly used therapies for cardiovascular disease on the pathobiology of endothelial dysfunction.
Allgemeiner Teil (1967)

Durch das Gesetz über die Versorgung der Opfer des Krieges vom 20. Dezember 1950 — Bundesversorg;ungsgesetz (BVG) — ist eine für das ganze Bundesgebiet geltende einheitliche Regelung der Leistungen an alle Beschädigte und deren Hinterbliebene geschaffen worden.
Coexistence of Quiescent and Active Adult Stem Cells in Mammals (2010)

Adult stem cells are crucial for physiological tissue renewal and regeneration after injury. Prevailing models assume the existence of a single quiescent population of stem cells residing in a specialized niche of a given tissue. Emerging evidence indicates that both quiescent (out of cell cycle and in a lower metabolic state) and active (in cell cycle and not able to retain DNA labels) stem cell subpopulations may coexist in several tissues, in separate yet adjoining locations. Here, we summarize these findings and propose that quiescent and active stem cell populations have separate but cooperative functional roles.
Near-Infrared Fluorescent Probes:  Synthesis and Spectroscopic Investigations of A Few Amphiphilic Squaraine Dyes (2005)

With the objective of developing near-infrared fluorescence probes for biological applications, a few squaraine dyes 3a-d, containing amphiphilic substituents, were synthesized and their photophysical properties have been investigated in the presence and absence of the organized media. These dyes exhibited absorption in the range 630-650 nm, with significant absorption coefficients (epsilon = 1-3 x 10(5) M(-1) cm(-1)) in the aqueous medium. The fluorescence spectra of these dyes showed emission maximum from 660 to 675 nm, depending on the nature of substituents. The fluorescence quantum yields were in the range from 0.15 to 0.21 in ethanol, but 10 times lower values were observed (phi(f) = 0.01-0.02) in the aqueous medium. In the presence of micelles such as cetyltrimethylammonium bromide, sodium dodecyl sulfate, and Triton X-100, these dyes showed negligible changes in their absorption properties, whereas a significant enhancement (5-10-folds) in their fluorescence yields was observed. Picosecond time-resolved studies indicated that these dyes show single-exponential decay in ethanol and ethanol-water mixtures; however, they exhibit biexponential decay with longer lifetimes in the presence of the micellar media. The results indicate that these novel amphiphilic squaraine dyes 3a-d, which exhibit favorable photophysical properties, good solubility in the aqueous medium, and interact efficiently with micelles, can have potential biological applications as near-infrared fluorescence sensors.
Effects of daily changes in environmental factors on the abundance and richness of Odonata (2011)

Aim: The aim of this work was to investigate the effects of daily changes in surface water abiotic factors on the abundance of Odonata larvae and the genus richness in a lateral lake isolated from a tropical river during the nycthemeral cycle in dry and wet seasons; Methods: Macrophytes were sampled on a single day at 6-hours intervals for 24 hours (at 12:00 AM, 6:00 AM, 12:00 PM and 6:00 PM) in dry and wet periods. At each site, abiotic factors were measured as follows: air temperature, surface water temperature, dissolved oxygen, pH, and electric conductivity. Canonical correspondence analysis (CCA) of abiotic and biological data and sampling periods was made using CANOCO program; Results: A total of 249 and 265 Odonata larvae from six genera (Acanthagrion, Cyanallagma, Telebasis, Erythemis, Erythrodiplax and Tauriphila) were sampled in association with macrophytes in wet and dry seasons, respectively. Telebasis presented the highest frequency of occurrence and was collected in all nycthemeral cycle sampling periods in both seasons. The highest abundance of dragonflies was recorded at 6:00 AM and 12:00 AM in wet and dry seasons, respectively. Anoxia was detected in wet season during the entire nycthemeral cycle, while in the dry season, the highest variability in oxygen content was observed during sunlight. Canonical correspondence analysis showed that the abundances of Telebasis and Erythemis were positively related to water electrical conductivity, temperature, and depth, while for Acanthagrion and Tauriphila, abundance showed a positive relationship to water oxygen and pH. The variability of the abundance of Odonata due to surface water temperature, dissolved oxygen, electrical conductivity, pH, and depth during the daily cycle was therefore evidenced; Conclusions: We suggested that the better sampling period Odonata larvae must to be carried in the morning , since that we recorded the highest densities of both wet and dry stations at that hour. We point out that our data must to be examined with caution because the low sampling effort and the reduced taxonomic resolution.
Phosphorus-Containing Poly(ethylene terephthalate): Solid-State Polymerization and Its Sequential Distribution (2013)

A series of phosphorus-containing copolyester prepolymers were first sythesized from dimethyl terephthalate (DMT), ethylene glycol (EG), and 2-carboxyethyl (phenyl)phosphinic acid (CEPPA) by molten transesterification and polycondensation, and then solid-state polymerization (SSP) was conducted for different reaction times (tSSP) so as to prepare higher molecular weight copolymers. The intrinsic viscosity was increased with the increase of tssp, but decreased with the increase of CEPPA content. The sequence distribution of resultant copolyesters was analyzed by 1H NMR. It was found that the randomness of copolyesters was decreased after SSP, and the transesterification occurred mainly at the ester bonds formed by CEPPA and EG, resulting in the chain growth. DSC results showed that SSP treatment was favorable to enhance the crystallization ability of the obtained copolyesters.
Nitrogen Mustards Related to Chloroquine, Pamaquine, and Quinacrine<sup>1</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitrogen Mustards Related to Chloroquine, Pamaquine, and Quinacrine1RALPH JONES Jr., CHARLES C. PRICE, and ACHINTYA K. SENCite this: J. Org. Chem. 1957, 22, 7, 783–786Publication Date (Print):July 1, 1957Publication History Published online1 May 2002Published inissue 1 July 1957https://pubs.acs.org/doi/10.1021/jo01358a017https://doi.org/10.1021/jo01358a017research-articleACS PublicationsRequest reuse permissionsArticle Views196Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts