gebhart/patrepeval huggingface dataset:
IPv6 Addresses as Content Names in Information-Centric Networking (2012)

Content is quickly beginning to emerge as the core of Internet and networking applications today. Among the most important research issues with content is the problem of addressing and naming content, since a robust and naming-centric networking strategy will enable the building of next-generation Internet architectures that can easily scale content demands correctly. We propose a counter-intuitive approach to solving the naming problem, by using IPv6 addresses as content names. We explain our proposal and architecture for using IPv6 addresses for content names, and argue that using IPv6 addresses for naming content will allow us to solve the problems of routing and directory services associated with naming. 1.
Increased Variability of Genomic Transcription in Schizophrenia (2015)

Schizophrenia (SZ) is a severe chronic mental disorder with a high heritability. Current microarray analyses typically focus on identifying differentially expressed genes or enriched pathways relevant to phenotypes. Whether there is a variability change of the genomic transcription in diseases has rarely been explored. In this study, we compared coefficient of variation (CV, the ratio of the standard deviation to the mean) of genome transcription of early-onset SZ (EOS) patients with controls in a blood mRNA microarray dataset and a blood microRNA (miRNA) microarray dataset. Furthermore, we compared CV of the expression levels of 17 genes in blood of the 30 patients before and after the 12-week treatment using real-time quantitative PCR (RT-qPCR) analysis. Our results indicated a significant increase of CV of genome transcription in patients compared with controls in both the mRNA and the miRNA datasets. The 30 after-treatment patients showed a significant decrease of CV of gene expression compared with the before-treatment patients. Our study may implicate the blood gene expression variability in SZ, providing further evidence supporting the abnormality of peripheral blood transcriptome in SZ. Given that peripheral blood can be easily collected from patients and followed longitudinally, our results may indicate a new way to facilitate the identification of the signatures of clinical subtypes, their prognosis and treatment response.
Targeting Mammalian Target of Rapamycin by Rapamycin Prevents Tumor Progression in an Oral-Specific Chemical Carcinogenesis Model (2009)

The increased molecular understanding of cancerous growth may now afford the opportunity to develop novel therapies targeting specific dysregulated molecular mechanisms contributing to the progression of each cancer type. In this regard, the aberrant activation of Akt/mammalian target of rapamycin (mTOR) pathway is a frequent event in head and neck squamous cell carcinomas (HNSCC), thus representing a potential molecular target for the treatment of HNSCC patients. The ability to translate this emerging body of information into effective therapeutic strategies, however, has been hampered by the limited availability of animal models for oral malignancies. Here, we show that the administration in the drinking water to mice of 4-nitroquinoline-1 oxide, a DNA adduct-forming agent that serves as a surrogate of tobacco exposure, leads to the progressive appearance of preneoplastic and tumoral lesions in the tongue and oral mucosa, with 100% incidence after only 16 weeks of carcinogen exposure. Remarkably, many of these lesions evolve spontaneously into highly malignant SCCs few weeks after 4-nitroquinoline-1 oxide withdrawal. In this model, we have observed that the activation of the Akt-mTOR biochemical route represents an early event, which is already detectable in dysplastic lesions. Furthermore, we show that the inhibition of mTOR by the chronic administration of rapamycin halts the malignant conversion of precancerous lesions and promotes the regression of advanced carcinogen-induced SCCs. Together, these findings support the contribution of the mTOR signaling pathway to HNSCC progression and provide a strong rationale for the early evaluation of mTOR inhibitors as a molecular-targeted strategy for HNSCC chemoprevention and treatment.
Consistent view removal in transparent schema evolution systems (2002)

We have developed the transparent schema evolution (TSE) system that, simulating schema evolution using object-oriented views, allows for the interoperability of applications with diverse and even changing requirements. TSE relieves users of the risk of making existing application programs obsolete when run against the modified schema, because the old view schema is maintained while a new view schema is generated to capture the changes desired by the user. However TSE may be generating a large number of schema versions (object-oriented view schemata) over time, resulting in an excessive build-up of classes and underlying object instances-some of which may potentially no longer be in use. We propose to solve this problem by developing techniques for effective and consistent schema removal. First, we characterize four potential problems of schema consistency that could be caused by removal of a single virtual class; and then outline our solution approach for each of these problems. Second, we demonstrate that view schema removal is sensitive to the order in which individual classes are processed. Our solution to this problem is the development of a dependency graph model for capturing the class relationships, used as a foundation for selecting among removal sequences. Designed to optimize the performance of the TSE system by effective schema version removal, the proposed techniques will enable more effective interoperability among evolving software applications.
Fuzzy Q-Learning for Mobility Robustness Optimization in wireless networks (2013)

The high popularity of smartphones and mobile PCs is expected to increase wireless data traffic in the order of 1000 times by 2020 [1]. However, the current situation of Mobile Network Operator (MNO)s is characterized by increasing margin pressure due to declining revenues and an increasing cost base. Self-optimization functionalities, e.g. for Mobility Robustness Optimization (MRO), are essential means for reducing Operational Expenditure (OPEX). In particular, mobile user groups or moving networks at high speeds impose challenges and may severely degrade network performance as well as user experience. The Fuzzy Q-Learning-based approach presented in this paper aims at providing a generic basis for enabling self-optimizing and self-healing network operations. The designed concept consists of the following key components: Fuzzy Inference System (FIS), heuristic Exploration/Exploitation Policy (EEP), and Q-Learning (QL). Its performance in a reference scenario is compared with a trend-based handover (HO) optimization scheme presented in [2] and a scheme that assigns time-to-trigger (TTT) values based on velocity estimates.
A Review on Adsorption of Fluoride from Aqueous Solution (2014)

Fluoride is one of the anionic contaminants which is found in excess in surface or groundwater because of geochemical reactions or anthropogenic activities such as the disposal of industrial wastewaters. Among various methods used for defluoridation of water such as coagulation, precipitation, membrane processes, electrolytic treatment, ion-exchange, the adsorption process is widely used. It offers satisfactory results and seems to be a more attractive method for the removal of fluoride in terms of cost, simplicity of design and operation. Various conventional and non-conventional adsorbents have been assessed for the removal of fluoride from water. In this review, a list of various adsorbents (oxides and hydroxides, biosorbents, geomaterials, carbonaceous materials and industrial products and by-products) and its modifications from literature are surveyed and their adsorption capacities under various conditions are compared. The effect of other impurities on fluoride removal has also been discussed. This survey showed that various adsorbents, especially binary and trimetal oxides and hydroxides, have good potential for the fluoride removal from aquatic environments.
Fluid condition monitoring sensors for diesel engine control (2006)

Online monitoring of liquid operating media is an essential new tool to increase engine efficiency and to meet increasingly stringent exhaust gas requirements (e.g.. EU4/5). In this contribution, we present novel results on diesel applications of the prototype of an oil condition sensor. We demonstrate the advantages of simultaneous viscosity, permittivity, and temperature measurement for the efficient discrimination between different oil aging mechanisms. Besides permittivity and viscosity sensors, IR-spectroscopy is a new powerful tool for fluid condition monitoring. We present first results for a new prototype IR-sensor for engine fuels and show its capability to determine the concentration of alternative engine fuels like FAME (fatty acid methyl esther, "biodiesel") and ethanol as an example.
WorkloadCompactor (2017)

Service providers want to reduce datacenter costs by consolidating workloads onto fewer servers. At the same time, customers have performance goals, such as meeting tail latency Service Level Objectives (SLOs). Consolidating workloads while meeting tail latency goals is challenging, especially since workloads in production environments are often bursty. To limit the congestion when consolidating workloads, customers and service providers often agree upon rate limits. Ideally, rate limits are chosen to maximize the number of workloads that can be co-located while meeting each workload's SLO. In reality, neither the service provider nor customer knows how to choose rate limits. Customers end up selecting rate limits on their own in some ad hoc fashion, and service providers are left to optimize given the chosen rate limits.
Requirements for Zinc, Manganese, Calcium, and Magnesium in Wort (1997)

The effect of wort zinc, manganese, calcium, and magnesium on fermentation performance was investigated in 2-L laboratory fermentations. Trace metals were added at different concentrations to a 16°P wort. CO2 evolution rate, specific gravity, and pH were monitored throughout the fermentation. Fermentation performance was based on the time to end of fermentation. Under the conditions used, zinc was found to be maximally effective at a level of 0.1–0.15 mg/L; lower concentrations can result in slower fermentations. Zinc concentrations do not affect cell growth, but rather affect the specific rate of fermentation. The yeast's history with regard to zinc concentration has an effect on fermentation performance. No effect on fermentation performance was seen by increasing the manganese concentration fivefold, increasing the magnesium or calcium concentration twofold, or varying the Mg++/Ca++ ratio from one to four.
Concurrent mapping and localization using sidescan sonar (2004)

This paper describes and evaluates a concurrent mapping and localization (CML) algorithm suitable for localizing an autonomous underwater vehicle. The proposed CML algorithm uses a sidescan sonar to sense the environment. The returns from the sonar are used to detect landmarks in the vehicle's vicinity. These landmarks are used, in conjunction with a vehicle model, by the CML algorithm to concurrently build an absolute map of the environment and to localize the vehicle in absolute coordinates. As the vehicle moves forward, the areas covered by a forward-look sonar overlap, whereas little or no overlap occurs when using sidescan sonar. It has been demonstrated that numerous reobservations by a forward-look sonar of the landmarks can be used to perform CML. Multipass missions, such as sets of parallel and regularly spaced linear tracks, allow a few reobservations of each landmark with sidescan sonar. An evaluation of the CML algorithm using sidescan sonar is made on this type of trajectory. The estimated trajectory provided by the CML algorithm shows significant jerks in the positions and heading brought about by the corrections that occur when a landmark is reobserved. Thus, this trajectory is not useful to mosaic the sea bed. This paper proposes the implementation of an optimal smoother on the CML solution. A forward stochastic map is used in conjunction with a backward Rauch-Tung-Striebel filter to provide the smoothed trajectory. This paper presents simulation and real results and shows that the smoothed CML solution helps to produce a more accurate navigation solution and a smooth navigation trajectory. This paper also shows that the qualitative value of the mosaics produced using CML is far superior to those that do not use it.
Conformationally Gated Photoinduced Processes within PhotosensitizerAcceptor Dyads Based on Osmium(II) Complexes with Triarylpyridinio-Functionalized Terpyridyl Ligands:  Insights from Experimental Study (2006)

[(ttpy)Os(tpy-ph-TPH(3)(+))](3+) (2), [(ttpy)Os(tpy-xy-TPH(3)(+))](3+) (3), [(ttpy)Os(tpy-ph-TPH(2)(NO(2))(+))](3+) (4), and [(ttpy)Os(tpy-xy-TPH(2)(NO(2))(+))](3+) (5) are a series of dyads made of an Os(II) bis-tpy complex (tpy = 2,2':6',2"-terpyridine) as the photosensitizer (P) and 2,4,6-triarylpyridinium group (TP(+)) as the electron acceptor (A). These dyads were designed to form charge-separated states (CSS) upon light excitation. Together with analogous Ru(II) complexes (7-10), they have been synthesized and fully characterized. We describe herein how intramolecular photoinduced processes are affected when the electron-accepting strength of A (by nitro-derivatization of TP(+)) and/or the steric hindrance about intercomponent linkage (by replacing a phenyl spacer by a xylyl one) are changed. Electronic absorption and electrochemical behavior revealed that (i) chemical substitution of TP(+) (i.e., TP(+)-NO(2)) has no sizable influence on P-centered electronic features, (ii) reduction processes located on TP(+) depend on the intercomponent tilt angle. Concerning excited-state properties, photophysical investigation evidenced that phosphorescence of P is actually quenched in dyads 4 and 5 only. Ultrafast transient absorption (TA) experiments allowed attributing the quenching in conformationally locked dyad 5 to oxidative electron transfer (ET) from the (3)MLCT level to the TP(+)-NO(2) acceptor (k(el) = 1.1 x 10(9) s(-)(1)). For 4, geometrically unlocked, the (3)MLCT state was shown to first rapidly equilibrate (reversible energy transfer; k(eq) approximately 2 x 10(9) s(-)(1)) with a ligand centered triplet state before undergoing CSS formation. Thus, the pivotal role of conformation in driving excited-state decay pathways is demonstrated. Also, inner P structural planarization as a relaxation mode of the (3)MLCT states has been inferred from TA experiments.
ICAM-1-Induced Expression of Proinflammatory Cytokines in Astrocytes: Involvement of Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways (2000)

ICAM-1 is a transmembrane glycoprotein of the Ig superfamily involved in cell adhesion. ICAM-1 is aberrantly expressed by astrocytes in CNS pathologies such as multiple sclerosis, experimental allergic encephalomyelitis, and Alzheimer's disease, suggesting a possible role for ICAM-1 in these disorders. ICAM-1 has been shown to be important for leukocyte diapedesis through brain microvessels and subsequent binding to astrocytes. However, other functional roles for ICAM-1 expression on astrocytes have not been well elucidated. Therefore, we investigated the intracellular signals generated upon ICAM-1 engagement on astrocytes. ICAM-1 ligation by a mAb to rat ICAM-1 induced mRNA expression of proinflammatory cytokines such as IL-1alpha, IL-1beta, IL-6, and TNF-alpha. Examination of cytokine protein production revealed that ICAM-1 ligation results in IL-6 secretion by astrocytes, whereas IL-1beta and IL-1alpha protein is expressed intracellularly in astrocytes. The involvement of mitogen-activated protein kinases (MAPKs) in ICAM-1-mediated cytokine expression in astrocytes was tested, as the MAPK extracellular signal-regulated kinase (ERK) was previously shown to be activated upon ICAM-1 engagement. Our results indicate that ERK1/ERK2, as well as p38 MAPK, are activated upon ligation of ICAM-1. Studies using pharmacological inhibitors demonstrate that both p38 MAPK and ERK1/2 are involved in ICAM-1-induced IL-6 expression, whereas only ERK1/2 is important for IL-1alpha and IL-1beta expression. Our data support the role of ICAM-1 on astrocytes as an inflammatory mediator in the CNS and also uncover a novel signal transduction pathway through p38 MAPK upon ICAM-1 ligation.
CrkI and CrkII Function as Key Signaling Integrators for Migration and Invasion of Cancer Cells (2005)

Crk adaptor proteins play an important role during cellular signaling by mediating the formation of protein complexes. Increased levels of Crk proteins are observed in several human cancers and overexpression of Crk in epithelial cell cultures promotes enhanced cell dispersal and invasion, implicating Crk as a regulator of invasive responses. To determine the requirement of Crk for invasive signals, we targeted the CRKI/II gene by RNA interference. Consistent knockdown of CrkI/II was observed with two small interfering RNA targeting sequences in all human cancer cell lines tested. CrkI/II knockdown resulted in a significant decrease in migration and invasion of multiple malignant breast and other human cancer cell lines (MDA-231, MDA-435s, H1299, KB, and HeLa). Moreover, CrkI/II knockdown decreased cell spreading on extracellular matrix and led to a decrease in actin stress fibers and the formation of mature focal adhesions. Using immunohistochemistry, we show elevated CrkI/II protein levels in patients with breast adenocarcinoma. Together, these studies identify Crk adaptor proteins as critical integrators of upstream signals for cell invasion and migration in human cancer cell lines and support a role for Crk in metastatic spread.
Inactivation of Kanamycin A by Phosphorylation in Pathogenic <i>Nocardia</i> (1991)

Among the five species of pathogenic Nocardia, i.e., N. asteroides, N. brasiliensis, N. farcinica, N. nova and N. otitidiscaviarum, all strains of N. brasiliensis and N. farcinica showed resistance to an aminoglycoside antibiotic, kanamycin A, showing the MIC (minimum inhibitory concentration) values of more than 100 micrograms/ml. This species-specific difference in sensitivity was found to be explained by the production of an inactivation enzyme, aminoglycoside 3'-phosphotransferase APH(3'). Structural studies by mass and NMR spectroscopy on the inactivated substance produced by a cell-free extract of the Nocardia confirmed the conversion of kanamycin A to an inactive substance, kanamycin A 3'-phosphate. The MIC values of N. otitidiscaviarum and N. nova for kanamycin A, on the other hand, ranged from 0.78 micrograms/ml to 100 micrograms/ml, and both species were non-producers of APH(3'). Sensitivity to the antibiotic and APH(3') productivity of N. asteroides varied depending on the strain.
Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance (2014)

Cyclooxygenase (COX) is an enzyme involved in tumorigenesis and is associated with tumor cell resistance against platinum-based antitumor drugs. Cisplatin analogues were conjugated with COX inhibitors (indomethacin, ibuprofen) to study the synergistic effects that were previously observed in combination treatments. The conjugates ensure concerted transport of both drugs into cells, and subsequent intracellular cleavage enables a dual-action mode. Whereas the platinum(II) complexes showed cytotoxicities similar to those of cisplatin, the platinum(IV) conjugates revealed highly increased cytotoxic activities and were able to completely overcome cisplatin-related resistance. Although some of the complexes are potent COX inhibitors, the conjugates appear to execute their cytotoxic action via COX-independent mechanisms. Instead, the increased lipophilicity and kinetic inertness of the conjugates seem to facilitate cellular accumulation of the platinum drugs and thus improve the efficacy of the antitumor agents. These conjugates are important tools for the elucidation of the direct influence of COX inhibitors on platinum-based anticancer drugs in tumor cells.
Mechanistic Studies of Photoacid Generation from Substituted 4,6-Bis(trichloromethyl)-1,3,5-triazines (1997)

The photochemistry and photophysics of 2-methyl- (1), 2-(2‘-furylethylidene)- (2), and 2-[(4‘-methoxy)styryl]-4,6-bis(trichloromethyl)-1,3,5-triazine (3), three compounds that find application as photoacid generators in photoresist formulations, have been investigated under conditions of direct excitation and using various phenothiazine derivatives as photosensitizers. C−Cl bond cleavage is confirmed by laser flash photolysis as the primary photochemical step in the direct photolysis of these compounds; the chlorine atoms formed in this reaction can be detected by complexation with chloride anions or benzene. In the case of 1, this photodissociation occurs with a lifetime of <20 ns. The quantum yield of bond breaking for 1 after direct excitation as determined by laser flash photolysis and steady-state irradiations was found to be 30−40 times greater than for 2 and 3. The mechanism under sensitized conditions involves electron transfer from the excited phenothiazines to the triazines as the primary photochemical step; the rate constants for excited-state quenching exceed 109 M-1 s-1 for the T1 state and 1010 M-1 s-1 for the S1 state. The rate constants correlate with the free energy for electron transfer estimated from the excited-state energies and the oxidation potential of the sensitizers.
DO ISO14001 EMS COMPANIES IN MALAYSIA REWARD EMPLOYEES FOR ENVIRONMENTAL INITIATIVES (2010)

The environmental management literature recommends that companies committed towards achieving their sustainable environmental aspirations should establish a rewards scheme for reinforcing employee motivation in the search for innovative solutions to environmental problems. This paper will assess whether rewards1 will provide a good indicator of employee willingness to try eco-initiatives2 in some of the leading environmentally proactive ISO 14001 companies in Malaysia. Of the two hundred and twenty three survey responses used in the final data analysis, two hundred and eleven responses are from the recipients of the Malaysian Prime Minister's Hibiscus Award (PMHA). The PMHA was first launched in 1996 as Malaysia's premier private sector environmental award for business and industry. Moreover given that employees' job appraisals rarely include an environmental category, several environmental initiatives are proposed which could provide practitioners a tool to assess employees' performance evaluation. The data was treated to descriptive, reliability, validity and correlation analysis using the SPSS computer program version 16. The rewards and employee willingness to try eco-initiatives constructs exhibited good internal consistency and adequate construct validity. In summary the findings suggest that middle and lower level employees are rarely rewarded for their environmental initiatives.
Antiferromagnetic Resonance in Hydrated Copper Salts (1963)

The antiferromagnetic resonance in CuCl22H2O and LiCuCl32H2O were investigated experimentally using centimeter and millimeter microwaves at liquid helium temperature. Detailed study of a single crystal of CuCl22H2O shows a small deviation from the Nagamiya—Yosida theory and is explained by introducing an anisotropic exchange interaction. Similar results are presented for CoCl26H2O. Hysteresis of spin flopping at Hc was observed and a possible mechanism is discussed. Main feature of the antiferromagnetic resonance LiCuCl32H2O can be explained by the present theory as well as in CuCl22H2O.
Electromagnetism using bivectors (1980)

A more instructive presentation of electromagnetism is possible when the magnetic field is treated as a bivector quantity rather than as an axial vector quantity. The connection between the magnetic field and currents as its sources is more transparent. The Lorentz-Abraham analogy between the field quantities is more complete.