gebhart/patrepeval huggingface dataset:
Rapid Method for Detection of Anti-Recombinant Human Erythropoietin Antibodies as a New Form of Erythropoietin Resistance (1997)

Recombinant human erythropoietin (rHuEPO) is a sialoglycoprotein hormone that appears to be immunologically and biologically equivalent to the endogenous compound, enhancing erythropoiesis dose-proportionally. The recombinant product is structurally very similar, if not identical, to native human erythropoietin, being a 193-amino acid peptide from which a 27-amino acid leader sequence is cleaved. Evidence indicates that the arginyl residue at the carboxyl terminus is also removed. The 165-amino acid mature protein contains two disulfide bonds, and one O-linked and three N-linked carbohydrate chains. The major carbohydrate units are sialated tetraantennary saccharides, which are required for stability in vivo (1). Two different rHuEPO products have been developed, alpha and beta, with differences in carbohydrate structure (glycoforms). In spite of the fact that rHuEPO is produced in mammalian cell lines and despite its widespread use, relatively little information is available regarding its immunogenic character. To date, few reports have been published on the development of anti-rHuEPO antibodies (2)(3)(4)(5).

Because of anemia, with hemoglobin of 65 g/L, a patient with end-stage renal disease in chronic hemodialysis required treatment with rHuEPO. rHuEPO-alpha, 20 U/kg body weight three times weekly (Eprex, Cilag, Switzerland), was scheduled, with good initial hematological response. In the …
COMPARATIVE PHYSIOLOGY AND MORPHOLOGY OF SIX STRAINS OF STIGONEMATACEAN BLUE‐GREEN ALGAE<sup>1</sup> (1974)

SUMMARY Six strains of branched blue‐green algae were examined in a search for lines to an explanation for apparent noncompetitiveness. Classical taxonomic treatments were often inadequate for confident species determination; forms that were very differ their morphologically frequently “keyed” to the same species. Strain distinctions based on comparative morphological and physiological studies were inconclusive. With the exception of 1 species, there were no substantial differences in physiological rates. In addition to the branching habit, diversity of cellular form was found to be an outstanding group characteristic. Individual cells of developing trichomes became a spore‐like and then divided to produce either cell clusters or lateral branches. The eventual separation of daughter cells by sheath materials may be analogous to spore formation in Nostocales and could be the factor which determines the nature of these organisms. The Stigonemataceae may not represent the pinnacle of blue‐green algal development but may, instead, be a primitive and basic form linking coccoid and filamentous algae.
Isolation of Circulating Immune Complexes (1978)

A B S T R A C T Raji cells were used for the isolationi of complement-fixing antigen-antibody complexes from serum. Immune complexes bound to these cells were radiolabeled at the cell surface with lactoperoxidase. The complexes were then eluted from the cells with isotonic citrate buffer pH 3.2 or recovered by immunoprecipitation of cell lysates. The antigen and antibody moieties of the complexes were isolated by dissociating sucrose density gradient centrifugation or by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A variety of preformed immune complexes were successfully isolated from serum with this approach. In addition, these techniques were used to isolate and identify the antigens in immuine complexes in the serum of rabbits with chronic serum sickness and rats with Moloney virus-induced sarcomas. Methods were also developed for the production of' antisera against the antigenic moiety of immune complexes isolated from serum. Repeated challenge of' rabbits with whole Raji cells with bound complexes or eluates from such cells resulted in antibody production against the antigens of the immune complexes, although reactivity against cellular and serum components was also elicited. Monospecific antisera against the antigens in immune complexes were produced by immunizing rabbits with the alum-precipitated antigen isolated on sodium dodecyl sulfatepolyacrylamide gel electrophoresis. These techni(ues
Enterotoxigenic Escherichia coli Secretes a Highly Conserved Mucin-Degrading Metalloprotease To Effectively Engage Intestinal Epithelial Cells (2013)

Enterotoxigenic Escherichia coli (ETEC) is a leading cause of death due to diarrheal illness among young children in developing countries, and there is currently no effective vaccine. Many elements of ETEC pathogenesis are still poorly defined. Here we demonstrate that YghJ, a secreted ETEC antigen identified in immunoproteomic studies using convalescent patient sera, is required for efficient access to small intestinal enterocytes and for the optimal delivery of heat-labile toxin (LT). Furthermore, YghJ is a highly conserved metalloprotease that influences intestinal colonization of ETEC by degrading the major mucins in the small intestine, MUC2 and MUC3. Genes encoding YghJ and its cognate type II secretion system (T2SS), which also secretes LT, are highly conserved in ETEC and exist in other enteric pathogens, including other diarrheagenic E. coli and Vibrio cholerae bacteria, suggesting that this mucin-degrading enzyme may represent a shared virulence feature of these important pathogens.
Considerations of supporting seamless mobility to mobile user in Mobile IPTV environments (2010)

Mobile IPTV lets mobile users transmit and receive multimedia traffic, such as TV signals, audio, text and graphics, through IP-based networks with the support of quality of service(QoS) and quality of experience(QoE), mobility and interactivity [1]. To provide service feasibility, QoS and seamless mobility to mobile users, we consider mobility prediction, link stability, service requirements to develop resource reservation scheme in mobile IPTV environments. Thus, we study for mobility prediction and QoS-guaranteed mobile IPTV service prior to develop the resource reservation scheme.
Breast Cancer Sentinel Node Metastases: Histopathologic Detection and Clinical Significance (2001)

Routine examination of the SN specimen should include serial sections with H&E stain. Ongoing prospective clinical trials should help to define the clinical significance of SN micrometastases. Furthermore, these trials could help identify predictors of non-SN metastasis that would allow a subset of patients with a tumor-involved SN to avoid the morbidity of ALND.
Citrus Fruit: Biology, Technology and Evaluation (2008)

Post harvest biology and technology of citrus fruits is gaining importance as the therapeutic value of citrus fruits is realized and supported by the increase in health awareness among the general public. This book is the most comprehensive reference on citrus fruit biology, biotechnology and quality. Basic and applied scientific information is interwoven to serve the researcher, marketer, scientist, nutritionist, or dietician. With discussions of fruit morphology, anatomy, physiology and biochemistry and chapters on growth phases, maturity standards, grades and physical and mechanical characteristics of citrus trees, this book provides the foundation for understanding growth, harvest and post harvest aspects of these important plants. Insect-pests and diseases, irrigation, nutrition and rootstocks are also addressed. * Provides practical tips for post harvest management * Includes all aspects of citrus fruit biology, technology and quality evaluation. * Discusses biotechnological applications and potential fresh citrus fruit quality improvement * Evaluates medicinal and therapeutic applications and recent clinical findings * Exhaustive glossary included
Non-interference topology scheme in wireless sensor networks (2007)

一个新奇拓扑学计划，有多重活动水池方法(CMMSM ) 的房间，为信息的收集并且为在无线传感器网络监视的环境在这篇文章被建议。系统由许多静态的传感器组成，在察觉到地和多重活动水池的大规模散布了，航行在簇之中。精力的保存和协议的简化是在这个计划的重要设计考虑。不干涉拓扑学计划大部分与碰撞回避和随机的路由的能力简化完整分布式的通讯协议。在如此的拓扑学的簇头的全部的数字被分析，然后在一个回合的全部的精力消费的近似评估被执行。模拟结果证明 CMMSM 能节省可观的精力并且比低精力的适应聚类层次获得更高的产量(沥滤) 并且地理适应忠实(GAF ) 。
Nanotechnology, nanosurfaces and silicone gel breast implants: current aspects (2017)

Nanotechnology is defined as the design of products that interact with biological systems on the nanoscopic scale. Creating a controlled nanotexture and understanding the ways in which surface properties impact inflammatory response is of the utmost significance in designing implants that can provide satisfactory outcomes.
Novel Noninvasive Nuclear Medicine Imaging Techniques for Cardiac Inflammation (2017)

Nuclear medicine techniques offer valuable information in the assessment of myocardial inflammation. Given the possibility to directly visualize inflammatory activity, they represent useful tools for diagnosis, risk stratification, and therapy monitoring.
Identification of CTX-M-14 Extended-Spectrum β-Lactamase in Clinical Isolates of <i>Shigella sonnei</i> , <i>Escherichia coli</i> , and <i>Klebsiella pneumoniae</i> in Korea (2001)

CTX-M-14 beta-lactamase was identified in a stool isolate of Shigella sonnei and in blood isolates of Escherichia coli (one isolate) and Klebsiella pneumoniae (two isolates) from different parts of Korea. The amino acid sequence differed by one amino acid from CTX-M-9 (Ala-231--> Val) and was identical to that of beta-lactamases recently found in China and Japan.
The risk of low concentrations of antibiotics in agriculture for resistance in human health care (2016)

The contribution of antibiotic resistance originally selected for in the agricultural sector to resistance in human pathogens is not known exactly, but is unlikely to be negligible. It is estimated that 50% to 80% of all antibiotics used are applied in agriculture and the remainder for treating infections in humans. Since dosing regimens are less controlled in agriculture than in human health care, veterinary and environmental microbes are often exposed to sublethal levels of antibiotics. Exposure to sublethal drug concentrations must be considered a risk factor for de novo resistance, transfer of antimicrobial resistant (AMR) genes, and selection for already existing resistance. Resistant zoonotic agents and commensal strains carrying AMR genes reach the human population by a variety of routes, foodstuffs being only one of these. Based on the present knowledge, short treatments with the highest dose that does not cause unacceptable side-effects may be optimal for achieving therapeutic goals while minimizing development of resistance. Novel approaches such as combination or alternating therapy are promising, but need to be explored further before they can be implemented in daily practice.
Granulocyte colony-stimulating factor-producing ascending colon cancer as indicated by histopathological findings: report of a case. (2011)

Various types of granulocyte colony-stimulating factor (G-CSF)-producing malignant tumors have been reported. However, a G-CSF-producing colorectal cancer is rare. We present a case of G-CSF-producing ascending colon cancer. An 81-year-old man was referred to our hospital with right lower abdominal pain. A colon fiberscopy revealed an ascending colon tumor, and histological examination revealed tubular adenocarcinoma. He was admitted due to worsening abdominal pain. Although laboratory data showed an elevated white blood cell (WBC) count of 17000/mm3 with 77.8% neutrophils, elevated C-reaction protein (CRP) was insignificant (1.06 mg/dL), and he was afebrile. Because computed tomography indicated that the tumor penetrated into surrounding tissue, a semi-urgent ileocecal resection was performed. An abscess was not located. The tumor was staged as T3N2aM0 and as stage IIB according to the TNM classification. Microscopically, significant neutrophil infiltration between cancer cells was observed, suggesting the presence of a G-CSF-producing tumor. Immunohistochemical staining using a G-CSF antibody revealed cytoplasmic staining in cancer cells. The serum concentration of G-CSF upon admission was 334 pg/mL. After surgical resection, the WBC count decreased to within a normal range. These findings confirmed the diagnosis of G-CSF-producing ascending colon cancer. The prognosis of G-CSF-producing tumors is considered to be poor. Early diagnosis and surgical treatment are needed for patients with G-CSF-producing tumors, and continuous careful follow-up is required.
Pathologic pupillary signs: self-learning module, Part 1. (1991)

Designed for independent study, this module explores some of the common, but often missed, pupillary abnormalities and eye movement irregularities. Part 1 presents an introduction to the module, a prerequisite test (with answer key and study references), module objectives, and a pretest.
Search Patterns: Design for Discovery (2010)

Search is among the most disruptive innovations of our time. It influences what we buy and where we go. It shapes how we learn and what we believe. In this provocative and inspiring book, you'll explore design patterns that apply across the categories of web, ecommerce, enterprise, desktop, mobile, social, and real-time search and discovery. Filled with colorful illustrations and examples, Search Patterns brings modern information retrieval to life, covering such diverse topics as relevance, faceted navigation, multi-touch, personalization, visualization, multi-sensory search, and augmented reality. By drawing on their own experience-as well as best practices and evidence-based research-the authors not only offer a practical guide to help you build effective search applications, they also challenge you to imagine the future of discovery. You'll find Search Patterns intriguing and invaluable, whether you're a web practitioner, mobile designer, search entrepreneur, or just interested in the topic. Discover a pattern language for search that embraces user psychology and behavior, information architecture, interaction design, and emerging technology Boost enterprise efficiency and e-commerce sales Enable mobile users to achieve goals, complete tasks, and find what they need Drive design innovation for search interfaces and applications
Energetics of enzyme catalysis. (1978)

Quantitative studies of the energetics of enzymatic reactions and the corresponding reactions in aqueous solutions indicate that charge stabilization is the most important energy contribution in enzyme catalysis. Low electrostatic stabilization in aqueous solutions is shown to be consistent with surprisingly large electrostatic stabilization effects in active sites of enzymes. This is established quantitatively by comparing the relative stabilization of the transition states of the reaction of lysozyme and the corresponding reaction is aqueous solution.
Growth and Band Gap Control of Corundum-Structured α-(AlGa)<sub>2</sub>O<sub>3</sub> Thin Films on Sapphire by Spray-Assisted Mist Chemical Vapor Deposition (2012)

Following the previous achievement of highly crystalline α-Ga 2 O 3 thin films on c -plane sapphire, the growth of corundum-structured α-(Al x Ga 1- x ) 2 O 3 was examined aiming at the future application of α-(Al x Ga 1- x ) 2 O 3 /Ga 2 O 3 heterostructures to power devices and other functional devices. The results show the control of x and band gap up to 0.81 and 7.8 eV, respectively, maintaining the dominant corundum structure. The transmission electron microscope observation suggested the formation of the crystallographically good interface of α-(Al x Ga 1- x ) 2 O 3 /Ga 2 O 3 without the severe generation of threading dislocation lines from the interface.
Evaluation of the antirhinovirus chalcone Ro 09-0415 given orally to volunteers (1984)

Ro 09-0415, a phosphorylated 'pro-drug' of the potent antirhinovirus compound, 4' ethoxy-2'-hydroxy-4, 6' dimethoxy-chalcone (Ro 09-0410) was tested in a double-blind placebo-controlled trial for its protective effect against experimental rhinovirus infection. The maximum dose, 1200 mg bd, based on considerations of practicality and tolerance was given orally both before and after challenge with a sensitive rhinovirus, type 9. Plasma concentrations of active compound in excess of those required for the inhibition of rhinovirus type 9 in vitro were achieved, but there was no evidence to suggest that treatment with Ro 09-0415 had a beneficial effect. It is concluded that Ro 09-0415 given orally is unlikely to be of value in the prophylaxis or therapy of human rhinovirus infection.
Analyses of Phase-Matching for Noncollinear Three-Wave Mixing in Uniaxial Crystals (1990)

Noncollinear phase-matching for three-wave mixing in uniaxial crystals is studied theoretically. A very simple relation correlating the noncollinear angle with the phase-matching angles of the interacting beams emerges for noncollinear difference-frequency mixing similar to second harmonic generation and sum-frequency mixing.
Development of a monolithic sub-micron precision linear-motion mechanism (2010)

OF THE THESIS Development of a Monolithic Sub-Micron Precision LinearMotion Mechanism by Steven Chang Master of Science in Mechanical Engineering San Diego State University, 2010 For high precision applications, flexure-based mechanisms have long been popular as they allow highly repeatable motion without problems such as backlash and stiction associated with other motion transfer linkages. In fact, due to the inherent simplicity of flexure mechanisms, these structures have found use in optical alignment, in positioning of cutting tools for high precision machining, as a basis for MEMS structures, and in wafer alignment for photolithography. This thesis discusses the development of a novel monolithic flexure-based structure used for the application of a tool onto a sample. The mechanism is arranged as a nested configuration of two independently moving platforms: the first acts as the reference frame for tool position while the second provides the mount point for the tool. Due to the compliance between the two structures, we obtain a measure of the contact load acting on the tool from the deflection of the two structures relative to each other. However, for the purposes of attaining repeatable positioning, the hysteresis inherent in the piezoelectric actuator used presents a problem. To address this issue, a disturbance observer (DOB) controller is applied in estimating and canceling the hysteresis nonlinearity of the actuator. DOB controllers are conventionally used to compensate against external disturbances. However, in this case, we treat the hysteretic behavior of the actuator as a combination of a bounded hysteresis operator and a linear dynamic system thus treating the hysteresis as a disturbance input to be canceled by the DOB. Experimental results show the effectiveness of the DOB in hysteresis compensation. Finally, we explore the application of this system for depth sensing indentation (DSI). To verify the performance of this system, indentation tests were performed on aluminum samples. The resulting hardness and elastic modulus determined through testing were shown to be close to literature values.
Toward a Better Understanding of Ni-Based Ohmic Contacts on SiC (2011)

There is still little consensus regarding why low contact resistivity is achieved when Ni on n-type 4H- and 6H-SiC is annealed at temperatures of more than above 950°C. The objective of this paper is to provide an answer concerning to this question. It is has been reported that even Ni-based contacts formed in the n++ region exhibited a steep reduction of contact resistivity in an annealing temperature range > 900°C. This effect reduction cannot be explained by the carbon vacancy induced donor model (Vc model) proposed by Han and his coworkers [Appl. Phys. Lett., Vol. 79, p. 1816 (2001)]. And, it is clarified that It was observed that the surface of substrates annealed at 1000°C was not covered with not Ni2Si but with a thin layer of NiSi. Finally, a plausible model is proposed that as the result of annealing at higher temperatures, results in the formation of the a NiSi/SiC system is builtat the substrate interface, resulting in significant reduction in low causing contact resistivity to be reduced significantly.
Cross-coupling reaction of tert-alkyl halides with Grignard reagents in dichloromethane as a non-Lewis basic medium (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCross-coupling reaction of tert-alkyl halides with Grignard reagents in dichloromethane as a non-Lewis basic mediumMasatomi Ohno, Kazuo Shimizu, Kenichi Ishizaki, Tadashi Sasaki, and Shoji EguchiCite this: J. Org. Chem. 1988, 53, 4, 729–733Publication Date (Print):February 1, 1988Publication History Published online1 May 2002Published inissue 1 February 1988https://pubs.acs.org/doi/10.1021/jo00239a005https://doi.org/10.1021/jo00239a005research-articleACS PublicationsRequest reuse permissionsArticle Views2175Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A pilot clinical trial of oxcarbazepine in adults with attention deficit hyperactivity disorder (2005)

Despite the increasing recognition of attention deficit hyperactivity disorder (ADHD) in adults, there is a paucity of controlled pharmacological trials. Recent reports have suggested the potential usefulness of mood stabilizing drugs for ADHD. To this end, the authors completed a pilot study with oxcarbazepine for the treamtent of adults with ADHD. This was an open pilot study of oxcarbazepine (300–1500mg daily dosage) in adults who met DSM-IV criteria for ADHD. The treatment period was 8 weeks. Of the 9 subjects enrolled in the study (4 men, 5 women), 8 patients could be be included in the analysis. At the endpoint of the active treatment, a significantly high proportion of subjects was considered improved while receiving oxcarbazepine. ADHD symptom checklist scores (ADHD-IV rating scale, Conners ADHD adult rating scale, ADHD-selfrating [ADHD-SR] scale) showed significant reduction during the treamtent period. Treatment with oxcarbazepine was relatively well tolerated; dizziness, sedation and nausea were the most frequently reported adverse effects. The results of this investigation indicate that oxcarbazepine may be a potentially useful agent for the treatment of ADHD in adults.
DISCUSSION. THE CONSTRUCTION OF TIGNES DAM AND MALGOVERT TUNNEL. (1953)

Keywords CONSTRUCTION, DAMS, TUNNELS, CONCRETE, AGGREGATES, TEMPERATURE, CABLEWAYS, GROUTING, SYSTEMS TIGNES DAM, MALGOVERT TUNNE, CASTELO DO BODE, CLAERWEN DAM FRANCE, PORTUGAL... Show All