gebhart/patrepeval huggingface dataset:
Efficacy of Nintendo Wii Training on Mechanical Leg Muscle Function and Postural Balance in Community-Dwelling Older Adults: A Randomized Controlled Trial (2012)

Biofeedback-based Wii training led to marked improvements in maximal leg muscle strength (maximal voluntary contraction; rate of force development) and overall functional performance in community-dwelling older adults. Unexpectedly, static bilateral postural balance remained unaltered with Wii training. The high level of participant motivation suggests that biofeedback-based Wii exercise may ensure a high degree of compliance to home- and/or community-based training in community-dwelling older adults.
Transdermal estradiol and oral or vaginal natural progesterone: bleeding patterns (2010)

Transdermal estrogen replacement therapy combined with 100 mg of micronized NP administered per vagina from the 14th day to the 25th day of each 28-day cycle leads to good cycle control and provides excellent patient satisfaction without serious side-effects. This therapy could be a treatment of first choice in early postmenopausal patients.
Complete assignment of 1H and 13C signals of a triterpene from Agrimonia pilosa Ledeb. by 2D NMR (2009)

A known triterpene obtained from Agrimonia pilosa Ledeb. was identified as 1β, 2β, 3β, 19α-tetrahydroxyurs-12-en-28-oic acid. This paper reports the complete assignment of the structure of this compound by the method of 2D NMR for the first time.
Estudio Clínico Comparativo entre Colutorio de p-clorofenol y peróxido de hidrógeno con Colutorio de Clorhexidina al 0.12% en el Crecimiento de Placa Microbiana y Gingivitis (2010)

Se formuló un colutorio a base de p-clorofenol alcanforado y peróxido de hidrógeno, y considerando que no se disponían de antecedentes de eficacia y seguridad del colutorio, se realizó un ensayo clínico para medirlas utilizando un modelo de formación de placa microbiana y gingivitis en un período de cuatro días, como control positivo se uso un colutorio de clorhexidina al 0.12%. Participaron 26 sujetos en un estudio doble ciego cruzado y con distribución aleatoria. El colutorio en base a p-clorofenol alcanforado y peróxido de hidrógeno y el de clorhexidina tuvieron un similar efecto en el control de la formación de placa y antigingivitis. No hubo diferencias entre los acontecimientos adversos observados para el colutorio y el control. Por consiguiente, el colutorio en estudio podría ser una alternativa para el control químico de la placa microbiana y gingivitis en el tratamiento de la enfermedad periodontal. A camphorated p-chlorophenol and hydrogen peroxide-based mouthwash was prepared, and a clinical trial to measure the efficiency and safety records of the mouthwash -considering the lack of them- was carried out using a formation model of microbial plaque and gingivitis over a 4-day period, with a 0.12% chlorhexidine mouthwash as positive control. Twenty-six individuals participated in the randomized double-blind crossover study. The camphorated p-chlorophenol and hydrogen peroxide-based and chlorhexidine mouthwash had a similar effect in controlling the formation of plaque and antigingivitis. There was no difference between the adverse events observed for the mouthwash and the control. Therefore, the mouthwash in study might be an alternative to the chemical control of microbial plaque and gingivitis in the periodontal desease treatment.
Simian Virus 40 Infection of Humans (2003)

Since its discovery, simian virus 40 (SV40) has been one of the most intensely studied animal viruses. The molecular biology of SV40 has led to seminal discoveries in the fields of transcription, DNA replication, and oncogenic transformation ([19][1]). Over the last decade, provocative evidence has
Relationship between Asbestos Exposures and 8-Hydroxydeoxyguanosine Levels in Leukocytic DNA of Workers at a Chinese Asbestos-material Plant (1997)

AbstractAbstractThe objective of the study was to evaluate the level of 8-hydroxydeoxyguanosine (8-OHdG) in DNA of peripheral-blood leukocytes as a biological marker of asbestos exposure and/or its fibrotic effects in an occupational population exposed to asbestos. The setting was a large-scale asbestos plant in China producing brake linings, asbestos rubber, and textile using chrysotile. From a base population of active and retired workers with various levels of cumulative exposure to asbestos and grades of asbestosis, 39 study subjects were randomly selected to reflect incremental grades of asbestosis based On Chinese diagnostic standards. They consisted of 19 "normal" (control) and ten "suspected" and ten "definite" asbestosis-grade subjects, group-matched for age and sex. Leukocytic DNA was extracted from 5-mL samples of peripheral blood and 8-0HdG level measured by high-pressure liquid chromatography. A cumulative asbestos exposure index (CEI) was calculated for each subject as the summed product of duration and level of asbestos exposure per job, incorporating a job-exposure matrix. Geometric mean 8-OHdG levels showed a positive gradient in relation to increasing grades of asbestosis (control: 1.78, suspected: 2.21, definite: 2.58), with a significant difference between the control and definite-asbestosis subgroups (p < 0.05). The 8-0HdG level of the two subgroups combined as one "asbestosis" group was significantly higher than that of the control group (control: 1.78, asbestosis: 2.39, p = 0.01). Further, 8-OHdG levels were moderately correlated with CEls for all subjects (r = 0.35, p < 0.05) and with grades of asbestosis for all (r = 0.47, p < 0.01) and for male subjects (r = 0.43, p < 0.05). In multiple regression analyses, grade of asbestosis explained 27% of the total variation in 8-0HdG and was a better predictor than GEI or duration of exposure. Thus, the 8-ORdG level in leukocytic DNA is related to grade of asbestosis and to individual cumulative exposure and may serve as a biologic marker reflecting the status of oxidative DNA damage by asbestos.Keywords: 8-hydroxydeoxyguanosineasbestos exposureepidemiology
Current Understanding of the Molecular Biology of Pancreatic Neuroendocrine Tumors (2013)

Pancreatic neuroendocrine tumors (PanNETs) are complicated and often deadly neoplasms. A recent increased understanding of their molecular biology has contributed to expanded treatment options. DNA sequencing of samples derived from patients with PanNETs and rare genetic syndromes such as multiple endocrine neoplasia type 1 (MEN1) and Von Hippel-Lindau (VHL) syndrome reveals the involvement of MEN1, DAXX/ATRX, and the mammalian target of rapamycin (mTOR) pathways in PanNET tumorigenesis. Gene knock-out/knock-in studies indicate that inactivation of factors including MEN1 and abnormal PI3K/mTOR signaling uncouples endocrine cell cycle progression from the control of environmental cues such as glucose, leading to islet cell overgrowth. In addition, accumulating evidence suggests that further impairment of endothelial-endocrine cell interactions contributes to tumor invasion and metastasis. Recent phase III clinical trials have shown that therapeutic interventions, such as sunitinib and everolimus, targeting those signal transduction pathways improve disease-free survival rates. Yet, cure in the setting of advanced disease remains elusive. Further advances in our understanding of the molecular mechanisms of PanNETs and improved preclinical models will assist in developing personalized therapy utilizing novel drugs to provide prolonged control or even cure the disease.
Sequence homology of the mitochondrial leucyl-tRNA cistron in different organisms (1975)

Sequence divergence of the mitochondrial leucytl-tRNA cistron in several eukaryotes has been examined by RNA-DNA hybridized. Rat mitochondria Leucyl-tRNA was hybridized with rat, mouse, guinea pig, monkey, chicken, and yeast mitochondrial DNAs (mtDNA) immobilized onfilters. Hybridization was carried out in 50% formamide (Tm -12degrees) or in 20% fromamide (Tm -21degrees). melting profiles of the hybrids were obtained for evaluation of the extent of base sequence micmatching. Under the more stringent hybridization conditions (50% formamide, Tm -12degrees), only mouse and quines pig mtDNAs hybridized with rat mitochondrial leucyl-tRNA. The Tm's of the heterohybrids were depressed by 2 and 9 degrees, respectively. Under less stringent hybridization conditions (Tm-21 degrees), monkey mtDNA also hybridized, and the Tm was depressed by about 15 degrees. Chicken and yeast mtDNAs did not form specific hybrids with rat mibochondrial leucyl-tRNA under these hybridization conditions. Mitochondrial leucyl-tRNA sequences in different eukaryotes appear to be conserved to a less extent than cytoplasmic rRNA, 5S RNA, or hemoglobin mRNA sequences.
<title>Raman mapping of plasma-treated and grafted polymer surfaces</title> (2001)

The grafting of polystyrene (PS) onto various polypropylene (PP) containing substrates, previously treated by exposure to a plasma, has been followed by Raman microspectroscopic mapping. The substrates consisted of either pure PP, or blends of PP and ethylene-propylene rubber (EPR). For exactly the same section of polymer surface, Raman spectra were obtained at 1 micrometers intervals for small sections of each substrate, the surface after plasma-treatment, and the surface after PS grafting. Typically, the size of the sections studied was 50 micrometers X 50 micrometers . Raman maps were constructed indicating the crystallinity variation across the surface, and also the distribution of the EPR component in the substrate, and after plasma treatment. Raman maps were also constructed to show the distribution of the PS at the surface after the grafting reaction. Grafting was found to be heterogeneous. The overall amount of grafted PS depended on the amount of EPR in the substrate. For a particular substrate, increased concentrations of grafted PS were correlated with positions on the surface which had higher EPR after plasma treatment.
A diffusion method for making silver bromide based holographic recording material (1999)

A simple diffusion method for the distribution of ultrafine silver bromide grains in pre-coated gelatin and customized polymeric films for holographic recording has been developed. The method involves two steps: immersion of the pre-formed film in a solution of a silver salt, followed by agitation of the film in a solution of a bromide salt containing sensitizing dye. Repetition of the operation on the same film with different sensitizing dyes in the bromide bath enables the production of film with a panchromatic response. Transmission electron microscopy reveals a grain structure very suitable for use in holography. A reflection hologram made by this method has a similar brightness under the same exposure and processing conditions to one made from a proprietary hologram recording material currently available.
Synthesis of a New Heterobifunctional Linker, <i>N</i>-[4-(Aminooxy)butyl]maleimide, for Facile Access to a Thiol-Reactive <sup>18</sup>F-Labeling Agent (2003)

A new heterobifunctional linker containing an aldehyde-reactive aminooxy group and a thiol-reactive maleimide group, namely N-[4-(aminooxy)butyl]maleimide, was synthesized as a stable HCl salt by O-alkylation of either N-hydroxyphthalimide or N-(4-monomethoxytrityl)hydroxylamine, followed by N-alkylation of maleimide, in an overall yield of 18% (seven steps) or 29% (five steps), respectively. This heterobifunctional linker allowed a simple and efficient synthesis of a maleimide-containing thiol-reactive (18)F-labeling agent. Thus, N-[4-[(4-[(18)F]fluorobenzylidene)aminooxy]butyl]maleimide (specific activity: approximately 3000 Ci/mmol at end of synthesis) was synthesized in two steps involving the preparation of 4-[(18)F]fluorobenzaldehyde, followed by its aminooxy-aldehyde coupling reaction to the heterobifunctional linker, with an overall radiochemical yield of approximately 35% (decay corrected) within approximately 60 min from end of bombardment. Initial (18)F-labeling experiments were carried out using a thiol-containing tripeptide glutathione (GSH) and a 5'-thiol-functionalized oligodeoxynucleotide (5'-S-ODN) in phosphate-buffered saline (PBS, pH 7.5). After standing at room temperature for 10 min, the (18)F-labeled GSH and 5'-S-ODN were obtained in (18)F-labeling yields of approximately 70% and approximately 5% (decay-corrected), respectively. The heterobifunctional linker is easy to synthesize and provides a facile access to the maleimide-containing thiol-reactive (18)F-labeling agent, which could be advantageously employed in the development of (18)F-labeled biomomolecules for use with positron emission tomography.
Flash CS4 All-in-One For Dummies (2008)

Ready to take your Flash skills to the next level? Learn how to use Adobe Flash CS4 to create innovative interactive experiences! Flash CS4 All-In-One For Dummies shows you how to create professional, cool projects, step by step, from start to finish. Whether youre working on your first Flash project or youre a veteran Flash animator ready to get into more advanced applications, Flash CS4 All-In-One For Dummies walks you through Flashs new tricks and explains how to use them. Youll get the skinny on new features including inverse kinematics, motion tweening, and Motion Editor. Youll also find out how to: Work with panels Take advantage of an ActionScript Create and plan your first project Follow the ins and outs of Flash graphics Navigate your way around the swatches panel Get your video on the Web using YouTube Utilize Flash audio and video Develop with the Flash timeline To help you quickly find what you need, Flash CS4 All-In-One For Dummies is divided into eight minibooks: Introducing Flash Creating Graphics Animating Graphics Adding ActionScript 3.0 Magic Working with Flash Audio Working with Flash Video Getting Interactive Finalizing a Flash Project Flash CS4 All-In-One For Dummies will help make your experience animating in Flash much easier!
A Framework for Determining Realistic Capacity Bounds for Distributed Antenna Systems (2006)

In the current research on future cellular networks, both classical MIMO concepts, such as schemes achieving spatial diversity or spatial multiplexing, and also virtual MIMO concepts are observed. In the latter, multiple base stations serving different cells are grouped to form distributed antenna systems that can be exploited as large MIMO systems. For example, concepts such as joint detection in the uplink and joint transmission in the downlink can be applied in order to cancel or suppress inter-cell interference. In this paper, we focus on the uplink and introduce a framework to investigate capacity bounds in cellular networks that use conventional single-cell links or employ multi-cell joint detection. We observe both an ideal hexagonal cell setup and also the existing GSM cell setup in downtown Dresden, while initially computing the capacities based on idealistic assumptions, and then successively introducing more and more non-idealistic aspects, to finally obtain a good estimate of performance bounds in a real-world system. The paper illustrates capacity bounds and thus the benefits of distributed antenna systems, as well as the methodology of efficiently and realistically modelling the physical layer of future cellular networks
Wireless intelligent incontinence management system using smart diapers (2008)

This paper presents a wireless intelligent incontinence management system being developed for the University Malaya Medical Center (UMMC) that utilizes ldquosmartrdquo diapers to discreetly monitor and estimate wetness events, detect other relevant clinical conditions and alert staff by transmitting information via wireless technology to an intelligent central management system. We describe the hardware and software modules of the system and give results conducted on diaper experiments and the transmission range of the wireless technology.
Room-temperature InAlAs∕InGaAs∕InP planar resonant tunneling-coupled transistor (2005)

We report an experimental demonstration of room-temperature InAlAs∕InGaAs∕InP planar two-dimensional to two-dimensional resonant tunneling-coupled transistors, in which the tunneling characteristics such as negative differential resistance and peak current are controlled by a surface Schottky gate similar to the state-of-the-art high-electron-mobility transistors (HEMT) with high gain. The tunneling peak voltage was modulated linearly with the Schottky gate voltage with a ratio of nearly unity. Functionality of the device can also be switched between HEMT and tunneling transistor mode. The fabrication process is fully compatible with conventional HEMT processes, offering a fully integrable and scalable tunneling transistor technology.
Loop-Aware Memory Prefetching Using Code Block Working Sets (2014)

Memory prefetchers predict streams of memory addresses that are likely to be accessed by recurring invocations of a static instruction. They identify an access pattern and prefetch the data that is expected to be accessed by pending invocations of the said instruction. A stream, or a prefetch context, is thus typically composed of a trigger instruction and an access pattern. Recurring code blocks, such as loop iterations may, however, include multiple memory instructions. Accurate data prefetching for recurring code blocks thus requires tight coordination across multiple prefetch contexts. This paper presents the code block working set (CBWS) prefetcher, which captures the working set of complete loop iterations using a single context. The prefetcher is based on the observation that code block working sets are highly interdependent across tight loop iterations. Using automated annotation of tight loops, the prefetcher tracks and predicts the working sets of complete loop iterations. The proposed CBWS prefetcher is evaluated using a set of benchmarks from the SPEC CPU2006, PARSEC, SPLASH and Parboil suites. Our evaluation shows that the CBWS prefetcher improves the performance of existing prefetchers when dealing with tight loops. For example, we show that the integration of the CBWS prefetcher with the state-of-the-art spatial memory streaming (SMS) prefetcher achieves an average speedup of 1.16× (up to 4× ), compared to the standalone SMS prefetcher.
Heats of Hydrogenation of Compounds Featuring Main Group Elements and with the Potential for Multiply Bonding (2002)

Reaction enthalpies are calculated for the hydrogenation reactions of main group hydrides with the potential for multiple bonding, and thus the unsaturated character of these species is determined. In addition to the global minimum structures, which leave in some cases no hope for even a single E-E bond (E=Group 13, 14, or 15 element), calculations are also performed for geometries with maximum potential for multiple bonding. The trends down the groups and the periods are established. Interpretations have to take several factors into account. These factors sometimes work hand in hand but also against each other. We also include in our survey the species [HGaGaH]2- as a free anion and Na2[HGaGaH] as well as their hydrogenation products [H2GaGaH2]2- and Na2[H2GaGaH2]2-. The results show that the presence of the Na+ ions has a significant impact on their chemistry, and thus suggests that they are involved to a large extent in the bonding. Our results indicate that the compounds should be described as cluster compounds.
Therapeutic Preparations of Normal Polyspecific IgG (IVIg) Induce Apoptosis in Human Lymphocytes and Monocytes: A Novel Mechanism of Action of IVIg Involving the Fas Apoptotic Pathway (1998)

Therapeutic preparations of normal human IgG for i.v. use (i.v.Ig) exhibit a broad spectrum of immunoregulatory activities in vitro and in vivo. I.v.Ig has been shown to inhibit the proliferation of activated B and T lymphocytes and of several autonomously growing cell lines. In this study, we demonstrate that i.v.Ig induces apoptosis in leukemic cells of lymphocyte and monocyte lineage and in CD40-activated normal tonsillar B cells, involving, at least in part, Fas (CD95/APO-1) and activation of caspases. I.v.Ig-induced apoptosis was higher in Fas-sensitive HuT78 cells than in Fas-resistant HuT78.B1 mutant cells, and soluble Fas inhibited IVIg-induced apoptosis. I.v.Ig immunoprecipitated Fas from Fas-expressing transfectants and recognized purified Fas/glutathione-S-transferase fusion proteins upon immunoblotting. Affinity-purified anti-Fas Abs from i.v.Ig induced apoptosis of CEM T cells at a 120-fold lower concentration than unfractionated i.v.Ig. Inhibitors of cysteine proteases of the caspase family, caspase 1 (IL-1beta-converting enzyme) and caspase 3 (Yama/CPP32b), partially inhibited i.v.Ig-induced apoptosis of CEM cells. Furthermore, cleavage of poly(A)DP-ribose polymerase into an 85-kDa signature death fragment was observed in CEM cells following i.v.Ig treatment. Thus, normal IgG induces apoptosis in lymphocytes and monocytes. Our results provide evidence for a role of Fas, bring new insights into the mechanisms of action of i.v.Ig in autoimmune diseases, and suggest a role of normal Ig in controlling cell death and proliferation.
Tat engagement of p38 MAP kinase and IRF7 pathways leads to activation of interferon-stimulated genes in antigen-presenting cells (2013)

As a result of its interaction with transcription factors, HIV type 1 (HIV-1) Tat can modulate the expression of both HIV and cellular genes. In antigen-presenting cells Tat induces the expression of a subset of interferon (IFN)-stimulated genes (ISGs) in the absence of IFNs. We investigated the genome-wide Tat association with promoters in immature dendritic cells and in monocyte-derived macrophages. Among others, Tat associated with the MAP2K6, MAP2K3, and IRF7 promoters that are functionally part of IL-1 and p38 mitogen-activated protein kinase (MAPK) signaling pathways. The association correlated with their increased gene expression, increased activation of p38 MAPK and of phosphorylated signal transducer and activator of transcription 1 (STAT1), and consequent induction of ISGs. Probing these pathways with RNA interference, pharmacological p38 MAPK inhibition, and in cell lines lacking STAT1s or the type I IFN receptor chain confirmed the role of MAPKKs and IRF7 in Tat-mediated modulation of ISGs and excluded the involvement of IFNs in this modulation. Tat interaction with the 2 MAPKK and IRF7 promoters in HIV-1-infected cells and the resulting persistent activation of ISGs, which include inflammatory cytokines and chemokines, can contribute to the increased immune activation that characterizes HIV infection.