gebhart/patrepeval huggingface dataset:
Comparative Efficacy of 2 Topical Anesthetics for the Placement of Orthodontic Temporary Anchorage Devices (2009)

This study compared the effectiveness of topical benzocaine 20% versus a combination of lidocaine, tetracaine, and phenylephrine in providing sufficient analgesia for the placement of orthodontic temporary anchorage devices (TADs). The 2 topical anesthetics were tested against each other bilaterally using a randomized, double-blind, crossover design. The agents were left in place for the amount of time prescribed by the manufacturer. The TAD was then placed, and each subject rated the degree of pain on a Heft-Parker visual analogue scale. A pulse oximeter was used to record the preoperative and postoperative pulse rates. Statistically significant differences in perceived pain (P < .05) and success rate (P < .01) between drugs were seen, but no significant difference in pulse rate change between the topical anesthetics was observed (P > .05). It was concluded that when the efficacy of topical benzocaine and of a combination product was compared as the sole anesthetic to facilitate acceptable pain control for placement of orthodontic temporary anchorage devices, the combination product was considerably more efficacious.
Modelling of the interline power flow controller and the generalised unified power flow controller in Newton power flow (2003)

The latest generation FACTS controller named the convertible static compensator (CSC) was recently installed at the New York Power Authority (NYPA) Marcy substation as part of a project that will increase power transfer capability and maximise the use of the existing transmission network. Within the general framework of the CSC, two innovative FACTS controllers, the interline power flow controller (IPFC) combining at least two converters and the generalised unified power flow controller (GUPFC) combining at least three converters, can be configured. Mathematical models of the IPFC and GUPFC and their implementation in Newton power flow are reported. Numerical results based on the IEEE 30-bus 118-bus and 300-bus systems are presented to demonstrate the performance of the Newton power flow algorithm with incorporation of the IPFC and GUPFC.
Fleet: Model-based hand tracking with texture, shading and self-occlusions (2008)

International audience
Integrated Sample Processing System Involving On-Column Protein Adsorption, Sample Washing, and Enzyme Digestion for Protein Identification by LC−ESI MS/MS (2005)

An automated system has been developed for protein identification using mass spectrometry that incorporates sample cleanup, preconcentration, and protein digestion in a single stage. The procedure involves the adsorption of a protein or a protein mixture from solution onto a hydrophobic medium that is contained within a microcolumn. The protein is digested while still bound to the hydrophobic support. The peptides are then eluted from surface digestion to an electrospray ionization mass spectrometer for detection and sequencing. The entire system is fully automated wherein the mass spectrometer is collecting data continuously. We demonstrate that this system is capable of identifying standard protein samples at concentrations down to 100 nM. Further development of this technique may offer a potential solution for proteomics applications that require unattended operation, such as on-line monitoring and identification of microorganisms on the basis of the detection of their protein biomarkers.
Infrared Imaging and Spectroscopy Beyond the Diffraction Limit (2015)

Progress in nanotechnology is enabled by and dependent on the availability of measurement methods with spatial resolution commensurate with nanomaterials' length scales. Chemical imaging techniques, such as scattering scanning near-field optical microscopy (s-SNOM) and photothermal-induced resonance (PTIR), have provided scientists with means of extracting rich chemical and structural information with nanoscale resolution. This review presents some basics of infrared spectroscopy and microscopy, followed by detailed descriptions of s-SNOM and PTIR working principles. Nanoscale spectra are compared with far-field macroscale spectra, which are widely used for chemical identification. Selected examples illustrate either technical aspects of the measurements or applications in materials science. Central to this review is the ability to record nanoscale infrared spectra because, although chemical maps enable immediate visualization, the spectra provide information to interpret the images and characterize the sample. The growing breadth of nanomaterials and biological applications suggest rapid growth for this field.
Influence Of The Plastic Material Behaviour On The Prediction Of Forming Limits (2007)

Prediction of the onset of necking is of large importance in reliability of forming simulation in present automotive industry. Advanced material models require accurate descriptions of the plastic material behaviour including the effect of strain rate. The usual approach for identifying the forming limits in industry is the comparison of a calculated strain map (major against minor strain) with a measured forming limit curve. This approach does not take into account the influence of strain path changes. Prediction of forming limit curves with classical material models can already demonstrate that the forming limits are influenced by this strain path change effect. Including the effect of strain rate on the plastic material behaviour has a strong influence in prediction of onset of instability. Neglecting this effect leads to underestimation of forming capacity of the material in stretch forming parts in particular. The shape of the yield locus will influence the predicted forming limit curves in the region from plane strain to bi‐axial. Damage controlled failure will become more important using (advanced) high strength steels. This will affect the stress strain curve at high deformation grades. The work hardening is not only controlled by dislocation interaction, but also by void growth and possible presence of micro‐cracks at the interface between the hard en soft phases.
The DNA Replication Machine of a Gram-positive Organism (2000)

This report outlines the protein requirements and subunit organization of the DNA replication apparatus of Streptococcus pyogenes, a Gram-positive organism. Five proteins coordinate their actions to achieve rapid and processive DNA synthesis. These proteins are: the PolC DNA polymerase, tau, delta, delta', and beta. S. pyogenes dnaX encodes only the full-length tau, unlike the Escherichia coli system in which dnaX encodes two proteins, tau and gamma. The S. pyogenes tau binds PolC, but the interaction is not as firm as the corresponding interaction in E. coli, underlying the inability to purify a PolC holoenzyme from Gram-positive cells. The tau also binds the delta and delta' subunits to form a taudeltadelta' "clamp loader." PolC can assemble with taudeltadelta' to form a PolC.taudeltadelta' complex. After PolC.taudeltadelta' clamps beta to a primed site, it extends DNA 700 nucleotides/second in a highly processive fashion. Gram-positive cells contain a second DNA polymerase, encoded by dnaE, that has homology to the E. coli alpha subunit of E. coli DNA polymerase III. We show here that the S. pyogenes DnaE polymerase also functions with the beta clamp.
Evidence for a rolling‐circle mechanism of phage DNA synthesis from both replicative and integrated forms of CTXφ (2001)

The genes encoding cholera toxin, the principal virulence factor of Vibrio cholerae, are part of the circular single-stranded DNA genome of CTXphi. In toxigenic V. cholerae strains, the CTXphi genome is typically found in integrated arrays of tandemly arranged CTX prophages. Infected cells that lack a chromosomal integration site harbour the CTXphi genome as a plasmid (pCTX). We studied the replication of pCTX and found several indications that this plasmid replicates via a rolling-circle (RC) mechanism. The initiation and termination sites for pCTX plus-strand DNA synthesis were mapped to a 22 bp sequence that contains inverted repeats and a nonanucleotide motif found in the plus-strand origins of several RC replicons. Furthermore, similar to other RC replicons, replication of plasmids containing duplicated pCTX origins resulted in the deletion of sequences between the two origins and the formation of a single chimeric origin. Our previous work revealed that CTX prophage arrays give rise to hybrid CTX virions that contain sequences derived from two adjacent prophages. We now report that the boundaries between the sequences contributed to virions by the upstream and the downstream prophages in an array correspond to the site at which synthesis of plus-strand pCTX DNA is initiated and terminated. These data support the model that plus-strand CTXphi DNA is generated from chromosomal prophages via a novel process analogous to RC replication.
Thermodynamically Stable Blue Phases (2010)

We show theoretically that flexoelectricity stabilizes blue phases in chiral liquid crystals. Induced internal polarization reduces the elastic energy cost of splay and bend deformations surrounding singular lines in the director field. The energy of regions of double twist is unchanged. This in turn reduces the free energy of the blue phase with respect to that of the chiral nematic phase, leading to stability over a wider temperature range. The theory explains the discovery of large temperature range blue phases in highly flexoelectric "bimesogenic" and "bent-core" materials, and predicts how this range may be increased further.
Value of Immunohistochemical Laminin Staining in Transitional Cell Carcinoma of Human Bladder (1993)

A prospective immunohistochemical study of 66 human bladder biopsies with and without transitional cell carcinoma (TCC) of the bladder was performed to assess the diagnostic and prognostic value of laminin staining in TCC of the human bladder. In all normal and nonmalignant inflammatory specimens, a continuous intact basement membrane (BM) laminin could be identified. In bladder cancer specimens laminin staining revealed focal interruption of the subepithelial BM with microinvasion in 2 of 6 specimens initially diagnosed as Tis(Pis) and 7 of 25 specimens initially diagnosed as pTa tumors. A statistically significant association between the pT category and BM interruption was found (p < 0.025). BM loss was directly proportional with the stage of the tumor. However, no significant association could be observed between BM interruption and the grade of the tumor (p > 0.25). In a short-term follow-up (mean 16 months) a statistically significant correlation (p = 0.01) could be observed between tumor recurrence and BM integrity in that a higher recurrence rate and shorter recurrence-free interval was found in patients with interrupted BM versus those with intact BM. Assessment of the vascular BM-staining pattern revealed interruption in specimens from 5 patients who died from advanced metastatic tumors. The metastatic process was found to be closely associated with focal interruption of the subendothelial BM (p < 0.001). From our results it appears that the adjunct use of immunohistochemical laminin staining in the histopathologic examination of TCC of the bladder is essential in more exact identification of the different pathologic stages and is also of help in the more detailed prediction of tumor behavior and prognosis.
New Instrument for Rapid and Accurate Measurement of Ultrasonic Velocity and Attenuation Using a Minicomputer System (1979)

A new instrument has been developed for rapid continuous recording of temporal changes in ultrasonic velocity and attenuation constant in a material. A set of data of changes in velocity and attenuation is obtained within the interval of one echo train, usually 0.1 msec or longer. A high-speed minicomputer is used for controlling the whole electronic system and data processing. The accuracy is 10-5 to 10-6 for the velocity change and 10-3 for the attenuation change in a sample length of 3 cm. Data showing the speed and accuracy of the instrument are given.
A Model of Tissue-Engineered Ventral Hernia Repair (2006)

We have developed a tissue-engineered ventral hernia repair system using our novel aligned collagen tube and autologous skeletal muscle satellite cells. In this model system, skeletal muscle satellite cells were isolated from a biopsy, expanded in culture, and incorporated into our collagen tube scaffold, forming the tissue-engineered construct. We characterized the results of the repaired hernias on both the gross and microscopic scales and compared them to an unrepaired control, an autologous muscle repair control, and a collagen-tube-only repair. Untreated animals developed a classic hernia sac, devoid of abdominal muscle and covered only with a thin layer of mesothelial tissue. Significant muscle, small-diameter blood vessels, and connective tissue were apparent in both the autologous control and the engineered muscle repairs. The engineered muscle repairs became cellularized, vascularized, and integrated with the native tissue, hence becoming a "living" repair. A tissue-engineered construct repair of ventral hernias with subsequent incorporation and vascularization could provide the ultimate in anterior wall myofascial defect repair and would further the understanding of striated muscle engineering. The knowledge gained from our model system would have immediate application to mangled extremities, maxillofacial reconstructions, and restorative procedures following tumor excision in other areas of the body.
An essential yeast protein, CBF5p, binds in vitro to centromeres and microtubules. (1993)

Yeast centromere DNA (CEN) affinity column chromatography has been used to purify several putative centromere and kinetochore proteins from yeast chromatin extracts. The single yeast gene (CBF5) specifying one of the major low-affinity centromere-binding proteins (p64'/CBF5p) has been cloned and shown to be essential for viability of Saccharomyces cerevisiae. CBF5 specifies a 55-kDa highly charged protein that contains a repeating KKD/E sequence domain near the C terminus, similar to known microtubule-binding domains in microtubule-associated proteins 1A and 1B, CBF5p, obtained by overexpression in bacterial cells, binds microtubules in vitro, whereas C-terminal deleted proteins lacking the (KKD/E)n domain do not. Dividing yeast cells containing a C-terminal truncated CBF5 gene, producing CBF5p containing only three copies of the KKD/E repeat, delay with replicated genomes at the G2/M phase of the cell cycle, while depletion of CBF5p arrests most cells in G1/S. Overproduction of CBF5p in S. cerevisiae complements a temperature sensitivity mutation in the gene (CBF2) specifying the 110-kDa subunit of the high-affinity CEN DNA-binding factor CBF3, suggesting in vivo interaction of CBF5p and CBF3. A second low-affinity centromere-binding factor has been identified as topoisomerase II.
Magnetoexciton dispersion in graphene bilayers embedded in a dielectric (2009)

A study of the magnetoexciton binding energy in graphene bilayers embedded in a dielectric is presented. The calculations are based on the relativistic Bethe-Salpeter equation assuming a strong magnetic field regime where the lowest Landau-level approximation takes place. It is shown that in graphene bilayer structures the magnetoexciton mass (binding energy) is four times lower (higher) than the corresponding magnetoexciton mass (binding energy) in coupled quantum wells with parabolic dispersion.
Equal Opportunities and University Practice; Race, Gender and Disability: A Comparative Perspective (1994)

Summary This paper provides a comparative analysis of data arising from three recent surveys of equal opportunity practice in relation to race, gender and disability. The surveys gathered information from a range of university departments and included questions about departmental structures and organisation as well as curriculum development. Instances of good practice are described, and some implications explored for the further development of equal opportunities in higher education.
An experience of catalyst design using mathematical modeling (2006)

The report concerns an approach called the "kinetic-assisted design of catalysts" that has been widely used in the literature during the last ten years. Several examples of mathematical modeling application in catalyst design are presented. The roles and ratio of the active centers of "metallic" (Pt?) and "ionic" platinum (Pt n+) and the acid centers of Al2O3 (AC) in naphtha reforming catalysts are discussed. The role of the micro-distribution of active centers in the catalyst porous structure (among the pores with different size) was analyzed. The affect of porous structure on the reactions accompanied by the capillary condensation of some reagents was considered. It was demonstrated that different shapes of catalyst pellets may be optimal depending on the optimization criterion (effectiveness factor, bed productivity and others). The application of solid inert in the catalyst bed ("dilution" of the catalyst) in unsteady-state regimes was examined.
Establishment of oil‐degrading bacteria associated with cyanobacteria in oil‐polluted soil (1995)

A unique natural microbial cocktail with promising potential for remediating oil-polluted desert in the Gulf region is reported. Oil-degrading micro-organisms immobilized within dense cyanobacterial mats on oily coasts of the Arabian Gulf were successfully established in oil-contaminated sand. Those micro-organisms biodegraded 50% of the oil within 10-20 weeks. Nocardioforms belonging to the genus Rhodococcus predominated in the first few weeks, but after 22 weeks Pseudomonas spp. increased, sharing Rhodococcus in the predominance. Other oil-utilizing bacterial genera included Bacillus and Arthrobacter. Filamentous actinomycetes belonging to the genera Streptomyces and probably Thermoactinomyces, as well as fungi belonging mainly to Aspergillus and Penicillium increased in the contaminated sand during the experiment but declined later. Representative strains grew on spectra of the tested n-alkanes with chain lengths between C10 and C40, as sole sources of carbon and energy.
Fibrinogen Excretion in the Urine and Immunoreactivity in the Kidney Serves as a Translational Biomarker for Acute Kidney Injury (2012)

Fibrinogen (Fg) is significantly up-regulated in the kidney after acute kidney injury (AKI). We evaluated the performance of Fg as a biomarker for early detection of AKI. In rats and mice with kidney tubular damage induced by ischemia/reperfusion (I/R) or cisplatin administration, respectively; kidney tissue and urinary Fg increased significantly and correlated with histopathological injury, urinary kidney injury molecule-1 (KIM-1) and N-acetyl glucosaminidase (NAG) corresponding to the progression and regression of injury temporally. In a longitudinal follow-up of 31 patients who underwent surgical repair of abdominal aortic aneurysm, urinary Fg increased earlier than SCr in patients who developed postoperative AKI (AUC-ROC = 0.72). Furthermore, in a cohort of patients with biopsy-proven AKI (n = 53), Fg immunoreactivity in the tubules and interstitium increased remarkably and was able to distinguish patients with AKI from those without AKI (n = 59). These results suggest that immunoreactivity of Fg in the kidney, as well as urinary excretion of Fg, serves as a sensitive and early diagnostic translational biomarker for detection of AKI.
Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity (1992)

Chimeric human immunodeficiency virus type 1 (HIV-1) molecular clones differing only in the envelope V3 region were constructed. The V3 regions were derived from two HIV-1 isolates with a non-syncytium-inducing, non-T-cell-tropic phenotype and from four HIV-1 isolates with a syncytium-inducing, T-cell-tropic phenotype. When assayed in SupT1 cells, the two chimeric viruses with a V3 region derived from the non-syncytium-inducing isolates did not induce syncytia and showed a low level of replication. The four chimeric viruses with a V3 region derived from the syncytium-inducing isolates did induce syncytia and replicated efficiently in SupT1 cells. In A3.01 cells, which do not support syncytium formation, the V3 loop affected replication similarly. Upon prolonged culture in SupT1 cells, the phenotype of a non-syncytium-inducing, low-replicating chimeric HIV-1 converted into a syncytium-inducing, high-replicating phenotype. Mutations within the usually conserved GPGR tip of the loop, which were shown to be responsible for the conversion into the syncytium-inducing, high-replicating phenotype, had occurred. In vitro mutagenesis showed that coupled changes of amino acids at both sides of the tip of the V3 loop were able to convert the viral phenotype from non-syncytium-inducing, low replicating into syncytium inducing, high replicating. Our data show that the V3 loop is involved in both syncytium forming and replicative capacity of HIV-1.
Social Cognitive Influences on Physical Activity Behavior in Middle-Aged and Older Adults (2011)

These results provide further support for the use of SCT to physical activity behavior in middle-aged and older adults. Self-efficacy influenced physical activity both directly and indirectly via outcome expectations, suggesting that these variables should be targeted in physical activity interventions for middle-aged and older adults.
Higher Order Cochlea-Like Channelizing Filters (2008)

A design method is presented for contiguous-channel multiplexing filters with many channels covering a wide bandwidth. The circuit topology extends previous work on cochlea-like channelizers by introducing multiple resonator-channel filter sections. The new design provides increased stopband rejection, lower insertion loss, and improved passband shape compared with the earlier version while retaining a simple design method and a compact layout, and requires no post-fabrication tuning. Results of a three-pole ten-channel channelizer covering from 182 MHz to 1.13 GHz with 17.5% bandwidth channels and 1.1-dB insertion loss are presented, and agree well with theory. A discussion of the power handling of planar channelizers is also presented.
Disease Severity in a Murine Model of Lyme Borreliosis Is Associated with the Genotype of the Infecting<i>Borrelia burgdorferi</i>Sensu Stricto Strain (2002)

The pathogenicity of Borrelia burgdorferi sensu stricto clinical isolates representing 2 distinct ribosomal DNA spacer restriction fragment-length polymorphism genotypes (RSTs) was assessed in a murine model of Lyme disease. B. burgdorferi was recovered from 71.5% and 26.6% of specimens from mice infected with RST1 and RST3 isolates, respectively (P<.0001). The average ankle diameter and histologic scores for carditis and arthritis were significantly higher after 2 weeks of infection among mice infected with RST1 isolates than among those infected with RST3 isolates (P<.001). These clinical manifestations were associated with larger numbers of spirochetes in target tissues but not with the serum sensitivity of the individual isolates. Thus, the development and severity of disease in genetically identical susceptible hosts is determined mainly by the pathogenic properties of the infecting B. burgdorferi isolate. The RST1 genotype is genetically homogeneous and thus may represent a recently evolved clonal lineage that is highly pathogenic in humans and animals.