gebhart/patrepeval huggingface dataset:
Scientific Challenges of Convective-Scale Numerical Weather Prediction (2017)

Abstract After extensive efforts over the course of a decade, convective-scale weather forecasts with horizontal grid spacings of 1–5 km are now operational at national weather services around the world, accompanied by ensemble prediction systems (EPSs). However, though already operational, the capacity of forecasts for this scale is still to be fully exploited by overcoming the fundamental difficulty in prediction: the fully three-dimensional and turbulent nature of the atmosphere. The prediction of this scale is totally different from that of the synoptic scale (10 3 km), with slowly evolving semigeostrophic dynamics and relatively long predictability on the order of a few days. Even theoretically, very little is understood about the convective scale compared to our extensive knowledge of the synoptic-scale weather regime as a partial differential equation system, as well as in terms of the fluid mechanics, predictability, uncertainties, and stochasticity. Furthermore, there is a requirement for a drastic modification of data assimilation methodologies, physics (e.g., microphysics), and parameterizations, as well as the numerics for use at the convective scale. We need to focus on more fundamental theoretical issues—the Liouville principle and Bayesian probability for probabilistic forecasts—and more fundamental turbulence research to provide robust numerics for the full variety of turbulent flows. The present essay reviews those basic theoretical challenges as comprehensibly as possible. The breadth of the problems that we face is a challenge in itself: an attempt to reduce these into a single critical agenda should be avoided.
Synthesis of 4‐Substituted Pyrrolo[2, 3‐ <i>c</i> ]quinolines via Microwave‐Assisted C‐N Bond Formation (2018)

Abstract A metal‐free approach for the synthesis of 4‐substituted pyrolo[2, 3‐ c ]quinoline is reported in this paper. Synthesis of the target molecule started from easily available quinoline and was carried out in five steps. The fused pyrrolo‐quinoline unit was assembled using Bartoli indolization and the crucial final step involving microwave assisted C−N bond formation was carried out by reaction of 4‐chloro‐3 H ‐pyrrolo[2, 3‐ c ]quinolines and diverse aliphatic amines, in the presence of N , N ’‐diisopropylethylamine (DIPEA). Final molecules were obtained in good yields even in the presence of additional bromine functionality on the quinolines, thus demonstrating the selectivity of the developed coupling procedure and possibility of increasing the product diversity.
Research progress in validation of laboratory methods of assessing body composition (1984)

This paper presents various laboratory methods designed to estimate body composition and documents some of the progress in their validation. In addition to the well-known methods of densitometry, hydrometry, and spectrometry (40K), many other methods will be reviewed briefly for their relation to body composition. Emphasis is given to validation principles which need to be followed if new methods are to be developed. The reliance of past research on the two-component model and reference man is reviewed, and the need for multicomponent approaches to the study of body composition is emphasized. Past research using the two-component approach has until recently led to lack of research in developing new methodologies, has limited the potential usefulness of various laboratory methods in estimating body composition in different populations, and has made the relation of body composition to health, performance, and exercise an inexact science. The application of several multicomponent approaches to the characterization of both fat-free body composition and body composition of various populations will lead to the development of reference bodies so essential for the advancement of the field. The estimation of body composition changes with exercise, growth, development, and aging and the relation of body composition to health and physical performance are important areas for future research using various multicomponent approaches.
JPL encapsulation task (1986)

A detailed summary of the diverse encapsulation materials and techniques that evolved to meet the cost goals of the Flat-plate Solar Array (FSA) Project is presented. A typical solar cell now consists of low iron glass, two layers of ethylene vinyl acetate (EVA) polymers, a porous space, primers/adhesives, a back cover of Tedlar, and a gasket/seal for a volume cost of $1.30/sq ft. This compares well with the project goal of $1.40/sq ft.
Linking presentation documents using image analysis (2004)

Systems for recording presentations are becoming commonly available. Commercial solutions include authoring tools that let users create online representations by recording audio, video, and presentation slides while a talk is being given. A typical collection of presentation recordings may contain hundreds even thousands of recordings, making it very difficult to retrieve particular presentations and find specific points in the presentation. This paper describes a retrieval technique that utilizes the digital camera pictures taken during presentations. An enabling image matching algorithm is also described. The algorithm utilizes the text and the layout of presentation slides captured in different multimedia streams and documents. Experimental results show that our method yields to a high retrieval accuracy.
A common MSH2 mutation in English and North American HNPCC families: origin, phenotypic expression, and sex specific differences in colorectal cancer (1999)

The frequency, origin, and phenotypic expression of a germline MSH2 gene mutation previously identified in seven kindreds with hereditary non-polyposis cancer syndrome (HNPCC) was investigated. The mutation (A-->T at nt943+3) disrupts the 3' splice site of exon 5 leading to the deletion of this exon from MSH2 mRNA and represents the only frequent MSH2 mutation so far reported. Although this mutation was initially detected in four of 33 colorectal cancer families analysed from eastern England, more extensive analysis has reduced the frequency to four of 52 (8%) English HNPCC kindreds analysed. In contrast, the MSH2 mutation was identified in 10 of 20 (50%) separately identified colorectal families from Newfoundland. To investigate the origin of this mutation in colorectal cancer families from England (n=4), Newfoundland (n=10), and the United States (n=3), haplotype analysis using microsatellite markers linked to MSH2 was performed. Within the English and US families there was little evidence for a recent common origin of the MSH2 splice site mutation in most families. In contrast, a common haplotype was identified at the two flanking markers (CA5 and D2S288) in eight of the Newfoundland families. These findings suggested a founder effect within Newfoundland similar to that reported by others for two MLH1 mutations in Finnish HNPCC families. We calculated age related risks of all, colorectal, endometrial, and ovarian cancers in nt943+3 A-->T MSH2 mutation carriers (n=76) for all patients and for men and women separately. For both sexes combined, the penetrances at age 60 years for all cancers and for colorectal cancer were 0.86 and 0.57, respectively. The risk of colorectal cancer was significantly higher (p<0.01) in males than females (0.63 v 0.30 and 0.84 v 0.44 at ages 50 and 60 years, respectively). For females there was a high risk of endometrial cancer (0.5 at age 60 years) and premenopausal ovarian cancer (0.2 at 50 years). These intersex differences in colorectal cancer risks have implications for screening programmes and for attempts to identify colorectal cancer susceptibility modifiers.
Application of X-Ray Measurement to Bearing Failure Analysis (1983)

<div class="htmlview paragraph">X-ray measurement is a very useful tool for bearing failure analysis. Compressive residual stress is created under the bearing raceway if bearings are used under a contact stress higher than the critical value. Residual stress distribution measurement of a used bearing enables to presume contact stress in service. Half height breadth of diffracted X-rey also changes with the fatigue of the material. Therefore X-ray measurement may estimate the degree of fatigue of a used bearing. Fracture surface of a fractured bearing has sometimes a high tensile residual stress at the surface, from which we can presume the fracture toughness of the material and then calculate the fracture stress.</div> <div class="htmlview paragraph">X-RAY diffraction is a very useful tool for bearing failure analysis, because X-ray diffraction technique can detect sensitively macro and microscopic lattice changes of a surface layer of crystalline materials. We have been applying X-ray measurement for failure analysis of used bearings for over ten years. In this paper, estimations of contact stress, remaining life of used bearings, or fracture stress of fractured bearings are described as examples of X-ray failure analysis.</div>
Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific (1991)

We have studied the expression of mRNA encoding all known protein kinase C (PKC) isozymes (alpha, beta, gamma, delta, epsilon, zeta, and eta) in murine tumor cell lines that exemplify hemopoietic cells arrested at different stages of development as well as in normal hemopoietic cells. We demonstrate that some of the isozymes, PKC-alpha, -beta, and -eta, are differentially expressed in different lineages. PKC-alpha and -beta generally are not detectable in myeloid cell lines, where PKC-delta is the predominant isoform. Both PKC-alpha and -beta are abundant in most T and B lymphocytic lines, but steady state levels of PKC-beta mRNA are lowest in plasma cell tumors, which exemplify the terminally differentiated B lymphocyte. In contrast, the levels of PKC-alpha mRNA remain high in plasma cell tumors, and a novel, 2.5-kb PKC-alpha mRNA gains prominence. PKC-eta mRNA is the major PKC isoform expressed in T lymphocytes, but it also is highly abundant in some myeloid lines. PKC-delta is expressed at high levels in all the lines we studied, whereas PKC-epsilon and -zeta are found in most cells but only at rather low levels. Analysis of myeloid clones derived from bipotential B lineage progenitor cell lines suggests that the B cell phenotype is associated with the expression of PKC-alpha. The close correlation of protein levels with mRNA levels indicates that PKC expression in hemopoietic cells is mainly regulated at the level of mRNA. The lineage- and differentiation stage-specific patterns of PKC-isozyme expression presented here suggest the involvement of specific PKC isozymes in differentiation as well as lineage determination of hemopoietic cells.
Retinoic Acid Induction of Human Tissue-type Plasminogen Activator Gene Expression via a Direct Repeat Element (DR5) Located at −7 Kilobases (1995)

All-trans-retinoic acid (RA) and retinoids induce synthesis of tissue-type plasminogen activator (t-PA) in endothelial and neuroblastoma cells in vitro and in rats in vivo. In HT1080 fibrosarcoma cells, induction of t-PA-related antigen secretion and t-PA mRNA steady state levels by RA were found to depend on de novo protein and mRNA synthesis. Fragments derived from the 5'-flanking region of the t-PA gene (+197 to -9578 base pairs (bp)) were linked to the chloramphenicol acetyltransferase gene. Transfection studies demonstrated that the region spanning bp -7145 to -9578 mediated induction by RA. A functional retinoic acid response element (RARE), consisting of a direct repeat of the GGGTCA motif spaced by 5 nucleotides (t-PA/DR5), was localized at -7.3 kilobases. The t-PA/DR5 element interacted with the heterodimer composed of retinoic acid receptor alpha and retinoid X receptor alpha in vitro, whereas its mutation abolished induction by RA in transient expression. In human EA.hy926 hybrid endothelial and in SK-N-SH neuroblastoma cells, the activity of t-PA/DR5 was found to be independent of the intervening sequence (-632 to -7144 bp) and of its distance from the transcription initiation site. Staurosporine, an inhibitor of protein kinase activity, inhibited induction by RA, suggesting that it required protein phosphorylation.
Multilevel Secure Transaction Processing: Status and Prospects. (1996)

Since 1990, transaction processing in multilevel secure database management systems (DBMSs) has been receiving a great deal of attention from the database research community. Transaction processing in these systems requires modification of conventional scheduling algorithms and commit protocols. These modifications are necessary because preserving the usual transaction properties when transactions are executing at different security levels often conflicts with the enforcement of the security policy. Considerable effort has been devoted to the development of efficient, secure algorithms for the major types of secure DBMS architectures: kernelized, replicated, and distributed. An additional problem that arises uniquely in multilevel secure DBMSs is that of secure, correct execution when data at multiple security levels must be written within one transaction. Significant progress has been made in a number of these areas, and a few of the techniques have been incorporated into commercial trusted DBMS products. However, there are many open problems remain to be explored. This paper reviews the achievements to date in transaction processing for multilevel secure DBMSs. The paper provides an overview of transaction processing needs and solutions in conventional DBMSs as background, explains the constraints introduced by multilevel security, and then describes the results of research in multilevel secure transaction processing. Research results and limitations in concurrency control, multilevel transaction management, and secure commit protocols are summarized. Finally, important new areas are identified for secure transaction processing.
An Efficient Deep Learning Model to Predict Cloud Workload for Industry Informatics (2018)

Deep learning, as the most important architecture of current computational intelligence, achieves super performance to predict the cloud workload for industry informatics. However, it is a nontrivial task to train a deep learning model efficiently since the deep learning model often includes a great number of parameters. In this paper, an efficient deep learning model based on the canonical polyadic decomposition is proposed to predict the cloud workload for industry informatics. In the proposed model, the parameters are compressed significantly by converting the weight matrices to the canonical polyadic format. Furthermore, an efficient learning algorithm is designed to train the parameters. Finally, the proposed efficient deep learning model is applied to the workload prediction of virtual machines on cloud. Experiments are conducted on the datasets collected from PlanetLab to validate the performance of the proposed model by comparing with other machine-learning-based approaches for workload prediction of virtual machines. Results indicate that the proposed model achieves a higher training efficiency and workload prediction accuracy than state-of-the-art machine-learning-based approaches, proving the potential of the proposed model to provide predictive services for industry informatics.
Anti-ferroelectric ZrO<inf>2</inf>, an enabler for low power non-volatile 1T-1C and 1T random access memories (2017)

Recently it was demonstrated that an asymmetric DRAM capacitor stack can introduce non-volatility and at the same time outperform ferroelectric HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> based FeRAM in terms of cycle endurance. With the present work, we provide an in-depth study of the underlying mechanisms and perform a comprehensive retention study that characterizes ferroelectric memories. Piezoelectric force microscopy is applied to prove the ultimate scalability of the proposed concept beyond capacitor based application. Finally, switching density plots reveal a much lower device to device variability and high switching uniformity with respect to ferroelectric HfO2 based films.
Fabrication of GaAs MESFET Ring Oscillator on MOCVD Grown GaAs/Si(100) Substrate (1984)

GaAs MESFET ring oscillators were successfully fabricated on silicon substrate. GaAs epitaxial layers were grown directly by MOCVD on Si(100) substrate. A typical transconductance of 200 mS/mm was observed for the FET of 1.0 µm × 10 µm gate. A minimum propagation delay time of 51 ps/gate at a power dissipation of 1.1 mW/gate was observed for an E/D gate ring oscillator with gate length of 1.0 µm.
Ethyl Propiolate: A Simple and Convenient Peptide Coupling Reagent (2004)

International audience
Screening for von Hippel-Lindau disease by DNA polymorphism analysis (1992)

<h3>Objective.</h3> —Von Hippel-Lindau (VHL) disease is a rare, inherited multisystem neoplastic disorder. There is no biochemical test available to distinguish VHL disease gene carriers from their healthy siblings. We evaluated DNA polymorphism analysis as a method for identifying disease gene carriers. <h3>Design.</h3> —Prospective comparison of the results of DNA analysis with a comprehensive clinical screening examination. <h3>Setting.</h3> —The Clinical Center of the National Institutes of Health. <h3>Patients.</h3> —Blood was collected from 182 members of 16 families with VHL disease. Forty-eight asymptomatic individuals, at risk of developing this hereditary illness (with an affected parent or sibling), were examined for occult disease at the Clinical Center of the National Institutes of Health and tested by DNA polymorphism analysis. <h3>Results.</h3> —DNA polymorphism analysis predicted nine disease gene carriers and 33 individuals with the wild-type (normal) allele among the 48 individuals at risk of developing VHL disease; the test was not informative in six individuals. All nine individuals predicted to carry the VHL gene had evidence of occult disease on clinical examination. There was no clinical evidence of VHL disease in 32 of 33 individuals predicted to carry the wild-type allele. <h3>Conclusions.</h3> —DNA polymorphism analysis can identify individuals likely to carry the VHL disease gene among asymptomatic members of disease families. This technique serves to focus attention on those individuals who require periodic medical examination and may help to alleviate the morbidity and mortality associated with this disease. (<i>JAMA</i>. 1992;267:1226-1231)
A two-stage clinical trial of Phyllanthus amarus in hepatitis B carriers: failure to eradicate the surface antigen. (1994)

Phyllanthus amarus is not effective in clearing HBsAg in asymptomatic carriers of the antigen.
Effects of phorbol-12-myristate-13-acetate on the phenotypic program of cultured chondroblasts and fibroblasts. (1978)

Phorbol-12-myristate-13-acetate (PMA) has a prompt, differential, and partially reversible effect on cultured chick chondroblasts. Within 36 hr PMA transforms sessile, polygonal, epithelioid chondroblasts into motile, multilayered, fibroblastic cells. In PMA chick chondroblasts rapidly cease to synthesize two of their terminal luxury molecules, the type IV sulfated proteoglycan that characterizes the extracell matrix and a glycosylated protein with an apparent molecular weight of 180,000. This glycosylated protein constitutes approximately 5% of the total protein in normal chondroblasts. If returned to normal medium after 4 days in PMA, virtually 100% of the cells reinitiate the synthesis of their type IV sulfated proteoglycan, of the 180,000-dalton protein, and reacquire their polygonal, epithelioid morphology. If returned to normal medium after 12 days in PMA, the cells fail to synthesize their two characteristic luxury molecules, and 100% of the cells remain fibroblastic. PMA alters the morphology of chick fibroblasts but does not block synthesis of their characteristic type III sulfated proteoglycan. PMA proves to be a mitogen for chondroblasts but not for fibroblasts, in spite of the phenotypic similarities of these two cell types.
Coherent lidar airborne windshear sensor: performance evaluation (1991)

National attention has focused on the critical problem of detecting and avoiding windshear since the crash on 2 Aug. 1985 of a Lockheed L-1011 at Dallas/Fort Worth International Airport. As part of the NASA/FAA National Integrated Windshear Program, we have defined a measurable windshear hazard index that can be remotely sensed from an aircraft, to give the pilot information about the wind conditions he will experience at some later time if he continues along the present flight path. A technology analysis and end-to-end performance simulation measuring signal-to-noise ratios and resulting wind velocity errors for competing coherent laser radar (lidar) systems have been carried out. The results show that a Ho:YAG lidar at a wavelength of 2.1 microm and a CO(2) lidar at 10.6 microm can give the pilot information about the line-of-sight component of a windshear threat from his present position to a region extending 2-4 km in front of the aircraft. This constitutes a warning time of 20-40 s, even in conditions of moderately heavy precipitation. Using these results, a Coherent Lidar Airborne Shear Sensor (CLASS) that uses a Q-switched CO(2) laser at 10.6 microm is being designed and developed for flight evaluation in the fall of 1991.
Molecular Structure and Novel DNA Binding Sites Located in Loops of Flap Endonuclease-1 from Pyrococcus horikoshii (2002)

The crystal structure of flap endonuclease-1 from Pyrococcus horikoshii (phFEN-1) was determined to a resolution of 3.1 A. The active cleft of the phFEN-1 molecule is formed with one large loop and four small loops. We examined the function of the conserved residues and positively charged clusters on these loops by kinetic analysis with 45 different mutants. Arg(40) and Arg(42) on small loop 1, a cluster Lys(193)-Lys(195) on small loop 2, and two sites, Arg(94) and Arg(118)-Lys(119), on the large loop were identified as binding sites. Lys(87) on the large loop may play significant roles in catalytic reaction. Furthermore, we successfully elucidated the function of the four DNA binding sites that form productive ES complexes specific for each endo- or exo-type hydrolysis, probably by bending the substrates. For the endo-activity, Arg(94) and Lys(193)-Lys(195) located at the top and bottom of the molecule were key determinants. For the exo-activity, all four sites were needed, but Arg(118)-Lys(119) was dominant. The major binding sites for both the nick substrate and double-stranded DNA might be the same.
Geometric molecular similarity from volume‐based distance minimization: Application to saxitoxin and tetrodotoxin (1995)

Abstract The geometric molecular dissimilarity between two molecules is defined as the difference between the volume of their union minus the volume of their intersection. This dissimilarity has the mathematical properties of a distance. This distance is minimized under all rotations and translations using a discrete Broyden, Fletcher, Goldfarb & Shanno (B.F.G.S.) algorithm. The optimal geometric superimposition of saxitoxin and tetrodotoxin is discussed. © 1995 by John Wiley & Sons, Inc.