EMETINE TOXICITY IN MAN: STUDIES ON THE NATURE OF EARLY TOXIC MANIFESTATIONS, THEIR RELATION TO THE DOSE LEVEL, AND THEIR SIGNIFICANCE IN DETERMINING SAFE DOSAGE (1948)

Article1 May 1948EMETINE TOXICITY IN MAN: STUDIES ON THE NATURE OF EARLY TOXIC MANIFESTATIONS, THEIR RELATION TO THE DOSE LEVEL, AND THEIR SIGNIFICANCE IN DETERMINING SAFE DOSAGEGERALD KLATSKIN, M.D., HARRY FRIEDMAN, M.D.GERALD KLATSKIN, M.D.Search for more papers by this author, HARRY FRIEDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-5-892 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEmetine is an important drug in the treatment of amebiasis, even though it frequently fails to cure the intestinal form of the disease. It is indispensable in the management of amebic hepatitis and abscess,1it controls the dysenteric symptoms most effectively, and there is evidence to suggest that it improves the end results of treatment in intestinal amebiasis when used in conjunction with other amebicides.2Yet, fear of toxicity has led to the employment of ineffective doses and, in some instances, to the complete abandonment of emetine.23There is evidence to indicate, however, that moderate to large doses may be...Bibliography1. KLATSKIN G: Amebiasis of the liver: classification, diagnosis and treatment, Ann. Int. Med., 1946, xxv, 601. Google Scholar2. KLATSKIN G: Observations on amebiasis in American troops stationed in India, Ann. Int. Med., 1946, xxv, 773. Google Scholar3. ANDERSONLEAKE HHCD: The oral toxicity of emetine hydrochloride and certain related compounds in rabbits and cats, Am. Jr. Trop. Med., 1930, x, 249. CrossrefGoogle Scholar4. 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Author, Article, and Disclosure InformationAffiliations: *Received for publication June 2, 1947.From the Department of Internal Medicine, Yale University School of Medicine.†Formerly Chief of Medical Service, Schick General Hospital, Clinton, Iowa.‡Formerly Chief of Cardiovascular Section, Schick General Hospital, Clinton, Iowa PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEmetine Is Not Ipecac: Considerations for Its Use as Treatment for SARS-CoV2Muscle Toxicity of Drugs: When Drugs Turn Physiology into PathophysiologyDiuretics, Ipecac, and LaxativesToxicity and tissue distribution studies on the hydrochloride, bismuth iodide complex and a resinate of emetineInhibition of neuromuscular transmission in the intact rat by emetinePhase I and Pharmacokinetic Study of LU79553, a DNA Intercalating Bisnaphthalimide, in Patients With Solid MalignanciesEffects of myotoxins on skeletal muscle fibersEmetine-induced lactate dehydrogenase release, functional changes and electrocardiographic changes in the rat heart in vitroSudden onset of profound weakness in a toddlerAbuse of drugs associated with eating disordersIpecac-induced toxicity in eating disordersChemical Aversion Treatment of Alcohol Dependence. 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RADKEFatal myocarditis due to emetine hydrochloridePresent Day Treatment of AmebiasisElectrocardiographic changes under emetine therapyProtozoenkrankheitenTREATMENT OF AMEBIASIS WITH ATABRINE COMBINED WITH CARBARSONE*RYLE A. RADKEEffects of emetine hydrochloride on the electrocardiogram in manDeath Due to Cardiac Disease Following the Use of Emetine Hydrochloride in Conditioned-Reflex Treatment of Chronic Alcoholism 1 May 1948Volume 28, Issue 5Page: 892-915KeywordsAmebiasisCardiovascular diseasesDrugsFearHepatitisMedical servicesToxicity ePublished: 1 December 2008 Issue Published: 1 May 1948 PDF downloadLoading ...