gebhart/patrepeval huggingface dataset:
The measurement of atmospheric water vapor: radiometer comparison and spatial variations (1991)

Two water vapor radiometer (WVR) experiments were conducted to evaluate whether such instruments are both suitable and necessary to correct for propagation effects that are induced by precipitable water vapor (PWV) on signals from the Global Positioning System (GPS) and Very Long Baseline Interferometry (VLBI). WVRs are suitable for these corrections if they provide wet path delays to better than 0.5 cm. They are needed if spatial variations of PWV result in complicated, direction-dependent propagation effects that are too complex to be parameterized in the GPS or VLBI geodetic solution. In the first experiment, the suitability of radiometers were addressed by comparing six WVRs at Stapleton International Airport in Denver, Colorado, for two weeks. The second experiment addressed the question whether radiometers are needed for the detection of inhomogeneities in the wet delay. Three JPL D-series radiometers were operated at three sites in Colorado approximately 50 km apart. The WVRs simultaneously sampled PWV at different azimuths and elevations in search of spatial variations of PWV.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Association of Newly Identified Respiratory Viruses with Lower Respiratory Tract Infections in Korean Children, 2000–2005 (2006)

This study describes the features of LRTIs associated with newly identified viruses in children, compared with those associated with known viruses. Additional investigations are required to define the role of HBoV in LRTI.
Design and application of a metal wet-etching post-process for the improvement of CMOS-MEMS capacitive sensors (2009)

This study presents a process design methodology to improve the performance of a CMOS-MEMS gap-closing capacitive sensor. In addition to the standard CMOS process, the metal wet-etching approach is employed as the post-CMOS process to realize the present design. The dielectric layers of the CMOS process are exploited to form the main micro mechanical structures of the sensor. The metal layers of the CMOS process are used as the sensing electrodes and sacrificial layers. The advantages of the sensor design are as follows: (1) the parasitic capacitance is significantly reduced by the dielectric structure, (2) in-plane and out-of-plane sensing gaps can be reduced to increase the sensitivity, and (3) plate-type instead of comb-type out-of-plane sensing electrodes are available to increase the sensing electrode area. To demonstrate the feasibility of the present design, a three-axis capacitive CMOS-MEMS accelerometers chip is implemented and characterized. Measurements show that the sensitivities of accelerometers reach 11.5 mV G−1 (in the X-, Y-axes) and 7.8 mV G−1 (in the Z-axis), respectively, which are nearly one order larger than existing designs. Moreover, the detection of 10 mG excitation using the three-axis accelerometer is demonstrated for both in-plane and out-of-plane directions.
Acceleration planning based anti-swing and position control for double-pendulum cranes (2017)

For a double-pendulum crane system with multi-state variables, strong coupling and under-actuated, the mathematical model is a nonlinear second order differential equations and the controller is a multi-input single-output system, leading to the challenge of controller design. Most of the existing good methods are based on advanced control theories or optimization theories, but it is difficult to put into practical application. In this paper, an anti-swing and position controller based on trapezoidal acceleration spline curve programming is designed to achieve the control requirements of effective anti-swing and precise position under constraints of the maximum acceleration, maximum velocity and maximum swing angle. The method has strong robustness which can adapt to the different length of the rope and the mass of the load, the most important thing is that it can be implemented in almost all controller devices and is suitable for engineering applications. The simulation results prove the effectiveness of the method.
Parallel processing of large node B-trees (1990)

The performance improvement afforded by parallel processing of large-node B-trees is investigated. A node partitioning scheme to enhance concurrency for B-trees is presented. In the method, the tree height is reduced by increasing the node size. However, it is shown that increasing node size alone in conventional B-trees on parallel disks may not improve the response time, and may even degrade the performance. The proposed method achieves better performance while avoiding this anomaly.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Survival Analysis of Automobile Components Using Mutually Exclusive Forests (2014)

An ability to predict the mileage at failure of components in a complicated system, particularly in automobiles, is a challenging task. In the current work, a methodology for estimating the distribution of failure and survival rate of automobile components affected by multiple factors is presented. A novel adaptation of an ensemble recursive partitioning and tree-based learning method, mutually exclusive forest, is introduced. The proposed method is capable of handling a high dimensional dataset and maximizing the extracted information to estimate the distribution of mileage at failure of automobile components. Each tree in the proposed mutually exclusive forest uses a mutually exclusive set of factors in each of its constituent decision trees to classify the failure data. Information across the trees is combined to obtain the failure rate distribution of an automobile component with respect to mileage. A case study, based on real-world field failure data and censored data of automobile components, is presented to evaluate the proposed algorithm. Results show similar results to the C-Forest approach in terms of prediction quality, while generating models with significantly lower space that are easier to interpret.
Inhibition of the RNA polymerase III-mediated dsDNA-sensing pathway of innate immunity by vaccinia virus protein E3 (2010)

The vaccinia virus E3 protein is an important intracellular modulator of innate immunity that can be split into distinct halves. The C terminus contains a well defined dsRNA-binding domain, whereas the N terminus contains a Z-DNA-binding domain, and both domains are required for virulence. In this study, we investigated whether the E3 Z-DNA-binding domain functions by sequestering cytoplasmic dsDNA thereby preventing the induction of type I interferon (IFN). In line with this hypothesis, expression of E3 ablated both IFN-beta expression and NF-kappaB activity in response to the dsDNA, poly(dA-dT). However, surprisingly, the ability of E3 to block poly(dA-dT) signalling was independent of the N terminus, whereas the dsRNA-binding domain was essential, suggesting that the Z-DNA-binding domain does not bind immunostimulatory dsDNA. This was confirmed by the failure of E3 to co-precipitate with biotinylated dsDNA, whereas the recruitment of several cytoplasmic DNA-binding proteins could be detected. Recently, AT-rich dsDNA was reported to be transcribed into 5'-triphosphate poly(A-U) RNA by RNA polymerase III, which then activates retinoic acid-inducible gene I (RIG-I). Consistent with this, RNA from poly(dA-dT) transfected cells induced IFN-beta and expression of the E3 dsRNA-binding domain was sufficient to ablate this response. Given the well documented function of the E3 dsRNA-binding domain we propose that E3 blocks signalling in response to poly(dA-dT) by binding to transcribed poly(A-U) RNA preventing RIG-I activation. This report describes a DNA virus-encoded inhibitor of the RNA polymerase III-dsDNA-sensing pathway and extends our knowledge of E3 as a modulator of innate immunity.
Changes in Basal and Insulin and Amino Acid Response of Whole Body and Skeletal Muscle Proteins in Obese Men (2009)

The obesity-related impairment of protein metabolism is characterized by 1) a reduced turnover rate of skeletal muscle proteins in PA; 2) a lack of stimulation of mitochondrial protein synthesis by insulin and amino acid; and 3) a lower inhibition of WB proteolysis by insulin and amino acid. Alterations of selective muscle protein kinetics may predispose obese subjects to muscle metabolic dysfunction leading to type 2 diabetes.
<title>Simulation of the imaging performance of x-ray image intensifier/TV camera chains</title> (1995)

The signal and noise propagation through a generalized x-ray image intensifier/TV camera chain is modeled in terms of the modulation transfer function, two dimensional noise power spectrum, and detective quantum efficiency. The model covers effects of energy dependent x- ray absorption in the cesium iodide entrance screens, K-fluorescence and K-reabsorption, electron optics, output screens, lenses and also sensing with electronic pick-up tubes (plumbicons) or CCD sensors. Several Philips x-ray image intensifiers in combination with plumbicon TV-chains and with laboratory type CCD cameras are compared with the model. Based on the model results we further present an image simulation tool. The image simulation allows a direct evaluation of the impact of the individual components of the imaging chain on image quality. It is shown that future high resolution CCD systems can exhibit a superior image quality as compared with electronic pick-up tube systems.
A systems reliability approach to decision making in autonomous multi-platform systems operating a phased mission (2008)

This paper presents a decision making strategy for autonomous multi-platform systems, wherein a number of platforms perform phased missions in order to achieve an overall mission objective. Phased missions are defined for both single and multi-platform systems and a decision making strategy is outlined for such systems. The requirements for a tool performing such a strategy are discussed and methods and techniques, traditionally used for system reliability assessment, are identified to fulfill these requirements. Two examples are presented in order to demonstrate how a decision making tool would be employed in practice. Finally, a brief discussion of the efficient implementation of such a strategy is presented.
Synthesis of hydroxylated cyclohexenyl- and cyclohexanyladenines as potential inhibitors of S-adenosylhomocysteine hydrolase (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of hydroxylated cyclohexenyl- and cyclohexanyladenines as potential inhibitors of S-adenosylhomocysteine hydrolaseKakarla Ramesh, Michael S. Wolfe, Younha Lee, David Vander Velde, and Ronald T. BorchardtCite this: J. Org. Chem. 1992, 57, 22, 5861–5868Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/jo00048a018https://doi.org/10.1021/jo00048a018research-articleACS PublicationsRequest reuse permissionsArticle Views614Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Discordant patterns of linkage disequilibrium of the peptide-transporter loci within the HLA class II region. (1995)

Disequilibrium between genetic markers is expected to decline monotonically with recombinational map distance. We present evidence from the HLA class II region that seems to violate this principle. Pairwise disequilibrium values were calculated from six loci ranging in physical separation from 15 kb to 550 kb. The histocompatibility loci DRB1, DQA1, and DQB1, located on the distal end of the class II region, behave as a single evolutionary unit within which extremely high linkage disequilibrium exists. Lower but still significant levels of disequilibrium are present between these loci and DPB1, located at the proximal edge of the HLA complex. The peptide-transporter loci TAP1 and TAP2, located in the intervening region, reveal no disequilibrium with each other and low or negligible disequilibrium with the flanking loci. The action of two genetic process is required to account for this phenomenon: a recombinational hotspot operating between TAP1 and TAP2, to eliminate disequilibrium between these loci, and at the same time selection operating on particular combinations of alleles across the DR-DP region, to create disequilibrium in the favored haplotypes. The forces producing the patterns of disequilibrium observed here have implications for the mapping of train loci and disease genes: markers of TAP1, for example, would give a false impression as to the influence of DPB1 on a trait known to be associated with DQB1.
<i>Cannabis:</i> Pharmacology and Interpretation of Effects (1985)

A selective introductory review of the Cannabis literature is presented. Subjects reviewed include the relative psychoactivities of Cannabis constituents, the disposition and distribution of THC and its metabolites, the relative psychoactivities of THC metabolites, and the use of cannabinoid concentrations in physiological fluids in interpretations of the significance of Cannabis-induced effects. The pharmacology of cannabinoids in humans is emphasized.
Anti-IRS-1 Monoclonal Antibody, 6G5, Cross-reacts to IRS-2 (1996)

We previously reported the production of anti-IRS-1 monoclonal antibodies against human IRS-1 C-terminal portion. One of anti IRS-1 monoclonal antibodies, 6G5, was found to immunologically cross-react with IRS-2, which has been reported recently. The data presented here provide information arising from the use of the anti-IRS-1 MAb, 6G5; this MAb was found to be a useful reagent in studying the functional role of IRSs in the insulin-signaling system.
Anti-Inflammatory Effect of Ethanolic Extract of <i>Sargassum serratifolium</i> in Lipopolysaccharide-Stimulated BV2 Microglial Cells (2016)

Sargassum serratifolium was found to contain high concentrations of meroterpenoids, having strong antioxidant, anti-inflammatory, and neuroprotective activities. This study aims to investigate the anti-inflammatory mechanisms of an ethanolic extract of S. serratifolium (ESS) using lipopolysaccharide (LPS)-stimulated BV2 microglial cells and to identify the anti-inflammatory components in ESS. The level of proinflammatory cytokines was measured by enzyme-linked immunosorbent assay. The expression of inflammation-related proteins and mRNA was evaluated by Western blot and reverse transcription-polymerase chain reaction analysis, respectively. Anti-inflammatory activities of isolated components from ESS were analyzed in LPS-stimulated BV2 cells. ESS inhibited LPS-induced nitric oxide (NO) and prostaglandin E<sub>2</sub> and the expression of inducible NO synthase and cyclooxygenase-2. ESS also decreased the release of proinflammatory cytokines in a dose-dependent manner. LPS-induced nuclear factor-kappa B (κB) transcriptional activity and translocation into the nucleus were remarkably suppressed by ESS through the prevention of inhibitor κB-α degradation. The main anti-inflammatory components in ESS were identified as sargahydroquinoic acid, sargachromenol, and sargaquinoic acid based on the inhibition of NO production using LPS-stimulated BV2 cells. Furthermore, treatment with ESS significantly reduced levels of tumor necrosis factor-α and interleukin-1β stimulated with LPS in mouse hippocampus. Our results indicate that ESS can be used as a functional food or therapeutic agent for the treatment of neuroinflammatory diseases.
Down-regulation of E2F1 during ER stress is required to induce apoptosis (2015)

The endoplasmic reticulum (ER) has recently emerged as an alternative target to induce cell death in tumours, because prolonged ER stress results in the induction of apoptosis even in chemoresistant transformed cells. Here, we show that the DNA-damage-responsive pro-apoptotic factor E2F1 is unexpectedly downregulated during the ER stress-mediated apoptotic programme. E2F1 decline is a late event during the ER response and is mediated by the two unfolded protein response (UPR) sensors ATF6 and IRE1 (also known as ERN1). Whereas ATF6 directly interacts with the E2F1 promoter, IRE1 requires the involvement of the known E2F1 modulator E2F7, through the activation of its main target Xbp-1. Importantly, inhibition of the E2F1 decrease prevents ER-stress-induced apoptosis, whereas E2F1 knockdown efficiently sensitises cells to ER stress-dependent apoptosis, leading to the upregulation of two main factors in the UPR pro-apoptotic execution phase, Puma and Noxa (also known as BBC3 and PMAIP1, respectively). Our results point to a novel key role of E2F1 in the cell survival/death decision under ER stress, and unveil E2F1 inactivation as a valuable novel potential therapeutic strategy to increase the response of tumour cells to ER stress-based anticancer treatments.
Sand consolidation preflush dynamics (1977)

Laboratory testing has demonstrated that for effective sand consolidation, the resin must wet the surface of the sand grains. In those cases where the plastic resins lack this ability, a preflush that preferentially removes water in the presence of oil is essential, particularly when there has been a prior mud acid treatment. Radial field-scale model studies have demonstrated that preflush effectiveness was dependent on preflush volume, viscosity, and sand permeability. These studies showed that an optimum volume of 100 gal/ft was required for an effective preflush.
Physiological Regulation of the  -Amyloid Precursor Protein Signaling Domain by c-Jun N-Terminal Kinase JNK3 during Neuronal Differentiation (2005)

Beta-amyloid precursor protein (APP) is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the pathogenesis of Alzheimer's disease but whose normal biological function is unknown. Analogy to the Notch protein suggests that APP is a cell-surface receptor that signals via sequential proteolytic cleavages that release its intracellular domain (AICD) to the nucleus. Because these cleavages are major targets for therapeutic inhibition, it is critical to elucidate their physiological function. AICD is stabilized by Fe65, interacts with the transcriptional factor Tip60, and translocates to the nucleus. Here, we show that endogenous AICD in primary neurons is detectable only during a short period of time during differentiation in culture. During this transient rise, a portion of AICD localizes to the nucleus. Subsequently, phosphorylation of the APP cytoplasmic domain at threonine 668 appears to disrupt the stabilizing interaction with Fe65 and thus downregulate AICD-mediated signaling. Furthermore, we find that the neuron-specific c-Jun N-terminal kinase JNK3, but not JNK1 or JNK2, mediates a substantial portion of this phosphorylation. We conclude that endogenous AICD undergoes tight temporal regulation during the differentiation of neurons and is negatively regulated by JNK3 via phosphorylation of APP at Thr668.
TEST YOUR KNOWLEDGE OF PSYCHIATRIC AND PSYCHOSOCIAL NURSING (1985)

SMITH, SANDRA F. . RN. MS; KARASIK, DARLENE A . RN, MS; MEYER, BEVERLY J RN, MS Author Information
Complex fluoroanions in solution. XI. Complexes of silicon, germanium, and titanium tetrafluorides with simple anions (1980)

A fluorine-bridged silicon fluoroanion and many hexa-co-ordinate germanium and titanium fluoroanions have been identified in solution via fluorine magnetic resonance. A generalized shceme is used to correlate all fluorine chemical shift data for hexa-coordinate fluorine containing species.
IANA Allocations for Mobile Ad Hoc Network (MANET) Protocols (2009)

This document enumerates several common IANA allocations for use by
MANET protocols. The following well-known numbers are required: a UDP
port number, an IP protocol number, and a link-local multicast group
address.
Automatic code generation for database-oriented web applications (2002)

The paper presents an architecture for database-oriented web applications. Then it introduces concepts which form a foundation for a code generation tool that supports the software construction process in the web application domain. The tool follows simple rules about mapping JavaBean components to the database schema and generates components, as well as a set of standardized JSP pages. The mapping is specified as an instance of an XML Schema document presented here. Efficiency of this tool is analyzed in several projects.
An integrated ECT/ERT dual modality sensor (2009)

Capacitance and resistance tomography systems have been developed for visualizing the distributions of materials in an industrial process. They offer certain advantages over other tomography modalities, such as low cost, rapid response, no radiation and being non-intrusive. Single modal tomography could provide a satisfactory solution in most process applications. However, in some more complex applications, additional information is required for comprehensive understanding of the process under investigation. ECT and ERT are two most researched electrical tomography techniques. Individual ECT and ERT systems has been combined for dual modal measurement in recent years, however, the two sensors were located at two different cross-sections of the process, resulting in poor sensor integration and data fusion. As a result of the present research an integrated tomography system with capacitive and resistive sensors located at the same cross-section of the process has been developed. In the integrated system the use of both resistive and capacitive electrodes help eliminate mutual interferences between the two modalities. Experimental work with water-gas two-phase flow on vertical and horizontal pipes shows that the integrated system can provide effective dual modal measurements. The reconstructed images together with the stacked images are used to deduce such process parameters as gas holdup and flow velocity.