gebhart/patrepeval huggingface dataset:
Type-2 hepatorenal syndrome and refractory ascites: role of transjugular intrahepatic portosystemic stent-shunt in eighteen patients with advanced cirrhosis awaiting orthotopic liver transplantation. (2004)

We can notice how the setting of TIPS, at least in the presented case, has allowed the treatment of ascites and, furthermore, has lead to improvement of the renal functional parameters. It all implies the enormous advantage of a better management of the patient waiting for orthotopic liver transplantation and, most of all, the advantage of preparing the patient for the surgical intervention with normal renal functional parameters: in fact, it is well known that the increase of serum creatinine influences the pre- and post-orthotopic liver transplantation course, and in particular can modify the mortality rate of the patient list. The lack of effective alternative treatment modalities and the almost universally fatal outcome of hepatorenal syndrome make TIPS an attractive option in the treatment of hepatorenal syndrome as a bridge to orthotopic liver transplantation.
Malware Detection Based on Hybrid Signature Behaviour Application Programming Interface Call Graph (2012)

Problem statement: A malware is a program that has malicious intent. Nowadays, malware authors apply several sophisticated techniques such as packing and obfuscation to avoid malware detection. That makes zero-day attacks and false positives the most challenging problems in the malware detection field. Approach: In this study, the static and dynamic analysis techniques that are used in malware detection are surveyed. Static analysis techniques, dynamic analysis techniques and their combination including Signature-Based and Behaviour-Based techniques are discussed. Results: In addition, a new malware detection framework is proposed. Conclusion: The proposed framework combines Signature-Based with Behaviour-Based using API graph system. The goal of the proposed framework is to improve accuracy and scan process time for malware detection.
Functionalized Lipid–Polymer Hybrid Nanoparticles Mediated Codelivery of Methotrexate and Aceclofenac: A Synergistic Effect in Breast Cancer with Improved Pharmacokinetics Attributes (2017)

The present study was aimed to coencapsulate methotrexate (MTX) and aceclofenac (ACL) in fucose anchored lipid-polymer hybrid nanoparticles (Fu-LPHNPs) to achieve target specific and controlled delivery for developing therapeutic interventions against breast cancer. The effective combination therapy requires coadministration of drugs to achieve synergistic effect on tumor with minimum adverse effects. Present study investigates the potential of codelivery of MTX and ACL through LPHNPs in MCF-7 and triple negative breast cancer cells (MDA-MB-231). We obtained LPHNPs in the nanosize range (<150 nm) with better particle size distribution (<0.3). The entrapment and loading efficiency of MTX and ACL was calculated as 85-90% and 10-12%, respectively. The coumarin-6 LPHNP formulations showed rapid internalization within 2 h incubation with MCF-7 and MDA-MB-231 cells. With 8-10 times, greater bioavailability of drug-loaded LPHNPs than free MTX and ACL was obtained. Also, antitumor efficacy of MTX- and ACL-loaded LPHNPs was determined on DMBA-induced experimental breast cancer mouse model. This model showed better control over tumor growth with MTX- and ACL-loaded LPHNPs than the combination of MTX and ACL or MTX alone. ACL-loaded LPHNPs showed prophylactic and anticancer activity in DMBA-induced mouse model at higher dose (10 mg/kg). ACL-LPHNPs confer synergistic anticancer effect when administered in combination with MTX. In conclusion, ACL enhances the therapeutic and anticancer efficacy of MTX, when coencapsulated into fucose-anchored LPHNPs, as confirmed by cell viability and serum angiogenesis (IL-6, TNF-α, IL-1β, COX2, and MMP1) at both transcript and proteome level.
Note on a Pneumatic Method of Measuring Variations of the Acceleration of Gravity (1920)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis (2018)

While suppression of specific genes through aberrant promoter methylation contributes to different diseases including organ fibrosis, gene-specific reactivation technology is not yet available for therapy. TET enzymes catalyze hydroxymethylation of methylated DNA, reactivating gene expression. We here report generation of a high-fidelity CRISPR/Cas9-based gene-specific dioxygenase by fusing an endonuclease deactivated high-fidelity Cas9 (dHFCas9) to TET3 catalytic domain (TET3CD), targeted to specific genes by guiding RNAs (sgRNA). We demonstrate use of this technology in four different anti-fibrotic genes in different cell types in vitro, among them RASAL1 and Klotho, both hypermethylated in kidney fibrosis. Furthermore, in vivo lentiviral delivery of the Rasal1-targeted fusion protein to interstitial cells and of the Klotho-targeted fusion protein to tubular epithelial cells each results in specific gene reactivation and attenuation of fibrosis, providing gene-specific demethylating technology in a disease model.
Phenylethylamine, Tyramine and Other Trace Amines in Patients with Affective Disorders: Associations with Clinical State and Antidepressant Drug Treatment (1984)

In 22 patients with major affective disorders, phenyl-ethylamine (PE) excretion tended to be higher and more variable in 12 females (25 ± 39 μg/d) than in 10 males (8 ± 1 μg/day). In a subgroup of 15 patients studied intensively as part of a treatment trial with the MA0-inhibitors, clorgyline and pargyline, pretreatment PE excretion was not consistently associated with differences in severity of depression, anxiety, activation or hypomania, although almost all correlations with psychopathology were in the negative direction, including several [self-rated dysphoria (r=-.55), anger (r=-.49), functional deficit (r=-.59)] which were statistically significant. Excretion of m-tyramine (m-TA) also exhibited generally negative associations with psychopathology, including self-rated depression (r=-.52) and anxiety (r=-.59), while hypomania was positively correlated (r=.72). Significant cross-correlations among PE, m-TA, and p-TA were not present at baseline, but MAO-inhibitor treatment led to intercorrelated increases in these trace amines, as well as phenylethanolamine, o-TA and platelet MAO activity changes. Increased PE excretion was associated with significantly decreased self-rated depression and anxiety during MAO-inhibitor treatment. Some baseline cardiovascular measures were negatively correlated with PE excretion, including systolic blood pressure, pulse and plasma norepinephrine concentrations, while baseline p-TA excretion was significantly correlated with pulse increases and systolic and diastolic blood pressure reductions produced by standing. These associations suggest that further study of behavioral connections with PE and m-TA excretion and of cardiovascular interactions with p-TA and PE might be of interest. Our data could be considered consistent with an amended hypothesis relating phenylethylamine to a cluster of depression-related symptoms including dysphoria and anger, but not depressed mood alone.
Obesity and Surgical Wound Healing: A Current Review (2014)

Objective. The correlation between obesity and deficient wound healing has long been established. This review examines the current literature on the mechanisms involved in obesity-related perioperative morbidity. Methods. A literature search was performed using Medline, PubMed, Cochrane Library, and Internet searches. Keywords used include obesity, wound healing, adipose healing, and bariatric and surgical complications. Results. Substantial evidence exists demonstrating that obesity is associated with a number of postoperative complications. Specifically in relation to wound healing, explanations include inherent anatomic features of adipose tissue, vascular insufficiencies, cellular and composition modifications, oxidative stress, alterations in immune mediators, and nutritional deficiencies. Most recently, advances made in the field of gene array have allowed researchers to determine a few plausible alterations and deficiencies in obese individuals that contribute to their increased risk of morbidity and mortality, especially wound complications. Conclusion. While the literature discusses how obesity may negatively affect health on various of medical fronts, there is yet to be a comprehensive study detailing all the mechanisms involved in obesity-related morbidities in their entirety. Improved knowledge and understanding of obesity-induced physiological, cellular, molecular, and chemical changes will facilitate better assessments of surgical risks and outcomes and create efficient treatment protocols for improved patient care of the obese patient population.
A Novel Resource Scheduling Approach in Container Based Clouds (2014)

Cloud computing is a new paradigm to deliver computing resources to customers in a pay-as-you-go model. In this paper, the recently emerged container-based virtualization technology is adopted for building the infrastructure of a cloud data center. Cloud providers are concerned with the resource usage in a multi-type resource sharing environment while cloud customers desire higher quality of services. According to this, we propose a resource scheduling approach for the container virtualized cloud environments to reduce response time of customers' jobs and improve providers' resource utilization rate. The stable matching theory is applied to generate an optimal mapping from containers to physical servers. Simulations are implemented to evaluate our resource scheduling approach. The results show that our approach achieves a better performance for customers and maximal profits for cloud providers by improving the resource utilization.
3DMAPPR: A community-based underwater archaeological photogrammetry program in Perth, Western Australia (2016)

The Maritime Archaeology Association of Western Australia (MAAWA), in collaboration with Tempus Archaeology (TA) and with the support of the Maritime Archaeology Department of the Western Australian Museum (MADWAM), recently initiated the 3D Maritime Archaeological Project - Perth Region (3DMAPPR). Intended primarily as a community-oriented capacity-building exercise, the overall objectives of the initial stage of the project were twofold: (i) to assess the viability of employing a low-cost underwater 3D photogrammetry package to document maritime archaeological sites; and, (ii) to provide MAAWA members with a set of operational guidelines, training, and experience in underwater 3D photogrammetric recording and data processing techniques. It was intended that avocational 'citizen scientists' would then be able to help address current management priorities by making meaningful contributions to the ongoing documentation and monitoring of maritime archaeological sites in the Perth metropolitan region. Combined with another MAAWA initiative (the Shipwreck WA website and smart phone application, http://www.shipwreckswa.com), this data has the potential not only to inform ongoing management of maritime archaeological sites, but also to be used as a resource for research, public education and outreach. This paper provides an overview of activities undertaken as part of 3DMAPPR during the first year of its operation. After outlining the project background and rationale, the authors review several case studies and highlight the opportunities afforded by the adoption of underwater multi-image 3D photogrammetry in a non-specialist context.
New norfriedelene-1,3-dione from the root bark of Salacia oblonga (2003)

From the hexane extract of the root bark of Salacia oblonga a new norfriedelene-1,3-dione whose structure was established as 15a-hydroxy-24-nor-friedel-5-ene-1,3-dione has been isolated. Two known triterpenes, 25,26-oxidofriedelane-1,3-dione and 7,24-oxido friedelane-1,3-dione have also been isolated from the hexane extract of the rootbark. Structures of all compounds have been established by spectroscopic and chemical methods.
A Scalable Hybrid Approach to Switching in Metro Ethernet Networks (2007)

The most common technology in local area networks is the Ethernet protocol. The continuing evolution of Ethernet has propelled it into the scope of metropolitan area networks. Even though Ethernet is fast and simple, the spanning tree in Ethernet is inefficient in terms of network utilization and load balancing. In this work, we compare the performance of spanning tree and link state algorithms in the context of layer 2 switching. In addition, we introduce a hybrid scheme that is customized for metro Ethernet networks. The results show that the hybrid scheme increases utilization and reduces the congestion ratio and delay. The performance gained as compared to RSTP, link state, and MSTP are 20.9%, 9.4%, and 11.4%, respectively. In addition, the hybrid scheme is more scalable than using pure link state.
Orson Scott Card: The Book of Mormon as History and Science Fiction (1994)

Book Review| July 01 1994 Orson Scott Card: The Book of Mormon as History and Science Fiction Homecoming, Vols. 1-5. The Memory of Earth, The Call of Earth, The Ships of Earth, Earthfall, Keeper of Earth, Orson Scott Card.A Storyteller in Zion: Essays and Speeches, Orson Scott Card."An Open Letter to those who are concerned about ’plagiarism’ in The Memory of Earth", Orson Scott Card. Eugene England Eugene England Search for other works by this author on: This Site Google Review of Books on the Book of Mormon (1994) 6 (1994) (2): 59–78. https://doi.org/10.2307/44796972 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Eugene England; Orson Scott Card: The Book of Mormon as History and Science Fiction. Review of Books on the Book of Mormon 1 July 1994; 6 (1994) (2): 59–78. doi: https://doi.org/10.2307/44796972 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveUniversity of Illinois PressMormon Studies Review Search Advanced Search The text of this article is only available as a PDF. © 1994 Foundation for Ancient Research and Mormon Studies1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Structure and catalytic activity of CoχMg1–χAl2O4 spinel solid solutions. Part 1.—Cation distribution of Co2+ ions (1977)

The cation distribution in CoAl2O4 and in several CoχMg1–χAl2O4 solid solutions with χ ranging from 0.05 to 0.5 has been studied by magnetic susceptibility, reflectance spectroscopy, lattice parameter variation and analysis of some X-ray reflections whose intensities are particularly sensitive to variation in cation positions.The results show that all specimens have the cobalt ions in a predominantly tetrahedral distribution and that there is a change towards a random cation distribution when the preparation temperature is increased from 1073 to 1473 K. The fraction of Co2+ ions in tetrahedral sites, α, is equal to 0.82 and 0.77 for the CoAl2O4 spinel prepared at 1073 and 1473 K, respectively.The X-ray results show, moreover, that α does not vary significantly with composition for χ varying from 1.0 to 0.1. For the most dilute cobalt solid solution (χ= 0.05), however, the value of α is lower; this trend is observed in both series of specimens prepared at different temperatures and may be explained in terms of anion–anion contact effects.
Wafer Backside Particle Reduction By Optimizing AC3 Coating for Poly Etch Chamber (2011)

As semiconductor devices are being scaled down to CD (Critical Dimension) of 65nm and below, the control of chamber condition in Poly Etch chamber is critical to achieve stable CD and defect performance from wafer to wafer, lot to lot. AC3 (Advanced Chamber Condition Control) coating is widely used after traditional WAC (Waferless Auto Clean): an SiCl4 coating step is added after WAC to coat a thin layer on both chamber wall and ESC chuck. This layer maintains chamber in good condition for every wafer to achieve stable Etch Rate, CD and defect performance, while low quality coating makes wafer backside particle high. This paper introduces two key factors for SiCl4 coating quality control which affects wafer backside particle performance. One is SiCl4 gas overshoot, the other one is ESC temperature effect. The wafer backside particle high can finally cause wafer frontside high defect count.
Magnetic Study of <i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-Tetramethyl-<i>p</i>-phenylenediamine (Wurster’s Blue) Iodide Cation Radical (1990)

Abstract One of the Wurster’s blue cation radicals, which is composed of the N,N,N′,N′-tetramethyl-p-phenylenediamine cation and iodine anion moieties, was prepared and its magnetic susceptibility measured from 2.6 to 300 K. The cation radical underwent no phase transition within this temperature range in striking contrast with the first-order phase transition observed in perchlorate and tetrafluoroborate salts, regardless of similar crystallographic structures. In addition, the temperature dependence of the magnetic susceptibility could be well-reproduced by a dimer model: a thermally accessible triplet state lying above a singlet ground state with an energy separation of ΔE⁄k=229 K. This behavior is controversial regarding the crystallographic determination. The unusual magnetic properties of the iodide salt were discussed, together with the crystal structure, ESR and visible absorption data, in comparison with those of the other salts.
Enhanced propionic acid fermentation by <i>Propionibacterium acidipropionici</i> mutant obtained by adaptation in a fibrous‐bed bioreactor (2005)

Fed-batch fermentations of glucose by P. acidipropionici ATCC 4875 in free-cell suspension culture and immobilized in a fibrous-bed bioreactor (FBB) were studied. The latter produced a much higher propionic acid concentration (71.8 +/- 0.8 g/L vs. 52.2 +/- 1.1 g/L), indicating enhanced tolerance to propionic acid inhibition by cells adapted in the FBB. Compared to the free-cell fermentation, the FBB culture produced 20-59% more propionate (0.40-0.65 +/- 0.02 g/g vs. 0.41 +/- 0.02 g/g), 17% less acetate (0.10 +/- 0.01 g/g vs. 0.12 +/- 0.02 g/g), and 50% less succinate (0.09 +/- 0.02 g/g vs. 0.18 +/- 0.03 g/g) from glucose. The higher propionate production in the FBB was attributed to mutations in two key enzymes, oxaloacetate transcarboxylase and propionyl CoA: succinyl CoA transferase, leading to the production of propionic acid from pyruvate. Both showed higher specific activity and lower sensitivity to propionic acid inhibition in the mutant than in the wild type. In contrast, the activity of PEP carboxylase, which converts PEP directly to oxaloacetate and leads to the production of succinate from glucose, was generally lower in the mutant than in the wild type. For phosphotransacetylase and acetate kinase in the acetate formation pathway, however, there was no significant difference between the mutant and the wild type. In addition, the mutant had a striking change in its morphology. With a threefold increase in its length and approximately 24% decrease in its diameter, the mutant cell had an approximately 10% higher specific surface area that should have made the mutant more efficient in transporting substrates and metabolites across the cell membrane. A slightly lower membrane-bound ATPase activity found in the mutant also indicated that the mutant might have a more efficient proton pump to allow it to better tolerate propionic acid. In addition, the mutant had more longer-chain saturated fatty acids (C17:0) and less unsaturated fatty acids (C18:1), both of which could decrease membrane fluidity and might have contributed to the increased propionate tolerance. The enhanced propionic acid production from glucose by P. acidipropionici was thus attributed to both a high viable cell density maintained in the reactor and favorable mutations resulted from adaptation by cell immobilization in the FBB.
Recent advances in the potential applications of bioinspired superhydrophobic materials (2014)

This review highlights the recent advances made in the potential applications of superhydrophobic materials.
Study on PSD system control strategy for safety (2012)

How to effectively ensure the operational safety of the urban mass transit (UMT) system becomes one of the key issues in rail transit. By isolated the platform from the train to prevent accidental falls off the platform, the widely used platform screen door (PSD) system plays an important role in urban operational safety. This article firstly gave a brief introduction on PSD system including its functions and compositions, and obtained its safety requirement by hazard analysis. Based on these results, control strategy for safety was presented. Finally, the functional safety assessment on passenger anti-sandwiched circuit and signal safety circuit, which were two subsystems of a typical Chinese PSD system, was studied, and the effectiveness of the control strategy could be verified.
Torrefaction and Gasification of Hydrolysis Residue (2008)

When producing ethanol from lignocellulosic material using hydrolysis combined with fermentation, a large amount of residue consisting of mainly lignin is generated. A significant amount of energy ...
One-step synthesis of 2,3-dihydronaphtho[2,3-b]thiophene-4,9-diones by a new regioselective [3 + 2] photoaddition of photogenerated 2-mercapto-1,4-naphthoquinone with alkenes (1993)

2,3-Dihydronaphtho[2,3-b]thiophene-4,9-diones are formed in one-step reactions in 6–41 % yields by an unprecedented regioselective (3 + 2] photoaddition of 2-mercapto-1,4-naphthoquinone, generated by the photochemical decarbonylation of 5-hydroxynaphth[2,1-d]-1,3-oxathiol-2-one, with alkenes.
Total Synthesis of the Novel, Immunosuppressive Agent (−)-Pateamine A from <i>Mycale </i>sp. Employing a β-Lactam-Based Macrocyclization (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTotal Synthesis of the Novel, Immunosuppressive Agent (−)-Pateamine A from Mycale sp. Employing a β-Lactam-Based MacrocyclizationRobert M. Rzasa, Helene A. Shea, and Daniel RomoView Author Information Department of Chemistry, Texas A&M University College Station, Texas 77843-3255 Cite this: J. Am. Chem. Soc. 1998, 120, 3, 591–592Publication Date (Web):January 13, 1998Publication History Received10 October 1997Published online13 January 1998Published inissue 1 January 1998https://pubs.acs.org/doi/10.1021/ja973549fhttps://doi.org/10.1021/ja973549frapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1310Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Aldol reactions,Macrocyclization,Organic compounds,Stereochemistry Get e-Alerts