gebhart/patrepeval huggingface dataset:
Neurogenetics : methods and protocols (2003)

The rapid identification and characterization of neurologically relevant genes holds great potential for understanding not only the pathophysiologic mechanisms of neurological diseases, but also for improving their diagnosis and management. In Neurogenetics: Methods and Protocols, an international panel of recognized academic physicians, researchers, and clinical laboratory diagnosticians describe their best methods for characterizing these genes, their mutations, and their proteins. Providing detailed step-by-step instructions to ensure successful experimental results, these experts cover the key methods for mutation detection and screening, including discussions of quantitative PCR, trinucleotide repeat detection, sequence-based mutation detection, fluorescence in situ hybridization (FISH), in vitro protein expression systems, and studies of protein expression and function. Each method has been thoroughly tested and includes notes on troubleshooting and avoiding pitfalls. Comprehensive and timely, Neurogenetics: Methods and Protocols offers academic neurologists and clinical laboratory diagnosticians an authoritative collection of readily reproducible techniques that can greatly assist with the diagnosis, management, and understanding of the pathophysiologic mechanisms of neurological diseases
Rearrangement of (Polymethoxybenzyl)ammonium N-Methylides (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRearrangement of (Polymethoxybenzyl)ammonium N-MethylidesYasuhiro Maeda, Naohiro Shirai, Yoshiro Sato, and Hiroshi TatewakiCite this: J. Org. Chem. 1994, 59, 25, 7897–7901Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/jo00104a055https://doi.org/10.1021/jo00104a055research-articleACS PublicationsRequest reuse permissionsArticle Views120Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
El desarrollo de un rol de práctica avanzada en enfermería de urgencias y emergencias: reflexiones desde la experiencia en Irlanda (2010)

El rol de los practicantes de enfermeria avanzados [advanced nurse proctitioner (ANP)] ha sido establecido en los servicios de urgencias en el Hospital de Saint James en los ul­timos 12 anos. El exito de este rol se ha hecho evidente en multiples logros hasta la fe· cha: mejora en la calidad del servicio prestado, desarrollo profesional, imitacion y proli. feracion de este rol a nivel nacional. La satisfaccion expresada por los usuarios del servicio es el testimonio de un servicio de alta calidad. Los resultados de las investiga­ciones y otros indicadores de calidad como la mejora de los tiempos de consulta y alta, y el incremento de las horas en que prestan servicio sustentan la expansion de mas en­tidades clinicas a los casos por tratar. El desarrollo del ANP en los servicios de urgencias ha pavimentado el camino para otras innovaciones en la practica de enfermeria avan· zada (advanced nursing proctice) en el Hospital de Saint James y en otros hospitales al· rededor del pais. Los servicios de urgencias como el del Hospital de Saint James, donde el papel del ANP esta bien desarrollado, aportan un modelo de buena practica clinica y demuestran el espiritu de un trabajo fuertemente multi-disciplinar. [Emergencias 2010;22:220-225]
Modeling and Predicting Retweeting Dynamics on Microblogging Platforms (2015)

Popularity prediction on microblogging platforms aims to predict the future popularity of a message based on its retweeting dynamics in the early stages. Existing works mainly focus on exploring effective features for prediction, while ignoring the underlying arrival process of retweets. Also, the effect of user activity variation on the retweeting dynamics in the early stages has been neglected. In this paper, we propose an extended reinforced Poisson process model with time mapping process to model the retweeting dynamics and predict the future popularity. The proposed model explicitly characterizes the process through which a message gain its retweets, by capturing a power-law temporal relaxation function corresponding to the aging in the ability of the message to attract new retweets and an exponential reinforcement mechanism characterizing the "richer-get-richer" phenomenon. Further, we introduce the notation of weibo time and integrate a time mapping process into the proposed model to eliminate the effect of user activity variation. Extensive experiments on two Weibo datasets, with 10K and 18K messages respectively, well demonstrate the effectiveness of our proposed model in popularity prediction.
Low-cost interference lithography (2009)

The authors report demonstration of a low-cost (∼1000 USD) interference lithography system based on a Lloyd’s mirror interferometer that is capable of ∼300nm pitch patterning. The components include only a 405nm GaN diode-laser module, a machinist’s block, a chrome-coated silicon mirror, substrate, and double-sided carbon scanning electron microscopy (SEM) tape. The laser and the machinist’s block were assembled in a linear configuration, and to complete the system, the mirror and substrate were taped to perpendicular surfaces of the machinist’s block. Approximately 50 silicon substrates were prepared, exposed, and developed, after which some were inspected in a SEM. The associated laser spectrum was also measured, enabling calculation of the laser’s fringe visibility as it varied along the substrate surface. To compare the exposed resist pattern to the fringe visibility, the authors measured the first order diffraction efficiency as a function of position along the grating surface. Their measurements indicated that artifacts seen in both the optical spectrum and resulting grating patterns arose from the laser diode source, thus improving the source characteristics will be the topic of future work.
ChemInform Abstract: A Novel Synthetic Route to Ethyl 3‐Substituted‐trans‐2,3‐difluoro‐2‐acrylates and Their Reactions with Nucleophiles. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dipentafluorophenyl carbonate—a reagent for the synthesis of oligonucleotides and their conjugates (1994)

Please note that References 5 – 8 were missing from the printed version of this paper. The full set of References are reprinted below.
Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates (2012)

Children with anxious temperament (AT) are particularly sensitive to new social experiences and have increased risk for developing anxiety and depression. The young rhesus monkey is optimal for studying the origin of human AT because it shares with humans the genetic, neural, and phenotypic underpinnings of complex social and emotional functioning. In vivo imaging in young monkeys demonstrated that central nucleus of the amygdala (Ce) metabolism is relatively stable across development and predicts AT. Transcriptome-wide gene expression, which reflects combined genetic and environmental influences, was assessed within the Ce. Results support a maladaptive neurodevelopmental hypothesis linking decreased amygdala neuroplasticity to early-life dispositional anxiety. For example, high AT individuals had decreased mRNA expression of neurotrophic tyrosine kinase, receptor, type 3 (NTRK3). Moreover, variation in Ce NTRK3 expression was inversely correlated with Ce metabolism and other AT-substrates. These data suggest that altered amygdala neuroplasticity may play a role the early dispositional risk to develop anxiety and depression.
Photo-responsive systems and biomaterials: photochromic polymers, light-triggered self-assembly, surface modification, fluorescence modulation and beyond (2009)

There has been considerable interest in the application of photochromism to photo-responsive systems which has led to the development of new tailored smart materials for photonics and biomedical fields. Within a polymeric matrix photochromic isomerizations can be stimulated by light to reversibly alter the physical and chemical properties of a material such as LC phase, shape, surface wettability, permeability, solubility, self-assembly, size and fluorescence. The underlying principles behind photo-responsive behavior, subsequent applications and relevant examples are discussed in this review.
Web 2.0: sindicación de contenidos (RSS) (2006)

El autor hace un repaso sobre el origen y las aplicaciones mas populares de la Web2.0, tales como los blogs, fotoblogs, audioblogs, videoblogs y moblogs, para aterrizar en la Sindicacion de Contenidos o RSS. Ademas tambien se hace eco de las principales caracteristicas de esta tecnologia, esto es, la interactividad y la colaboracion social.
Magnetic properties of Co–Pt∕Co hard/soft stacked dot arrays (2008)

The magnetic properties of Co80Pt20(10nm)∕Co(0,3,5nm) hard/soft stacked dot arrays with dot diameters D of about 50nm were studied. Co–Pt films were deposited on Ru (001) seed layers, resulting in a large uniaxial magnetic anisotropy Ku with the c axis perpendicular to the film plane. Dot patterns were formed using high resolution e-beam lithography and reactive ion etching. Magnetic force microscopy images revealed that all dot arrays showed a single domain state, even after removal of an applied field equal to the coercivity. The remanence coercivity Hr decreased from 9.1to6.9kOe as the Co layer thickness increased from 0to5nm, indicating that the hard/soft stacked structure was effective at reducing the switching field, as theoretically predicted. The applied field angular dependence of Hr for 10-nm-thick Co–Pt dot arrays was in good agreement with calculations based on the Stoner–Wohlfarth model, HS-W indicating coherent rotation of the magnetization during nucleation. Moreover, it was confirmed that the hard/soft stacked structure reduced the angular variation of Hr.
Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients (2005)

Our findings suggest a link between loss of surfactant function driven by progressive airway inflammation and loss of small airway function in CF patients with limited lung disease.
Architectures for the implementation of a fixed delay tree search detector (1997)

This paper examines the tradeoff between fixed delay tree search (FDTS) detector complexity and performance with various modulation codes. Several architectures suitable for implementing FDTS or achieving performance comparable to FDTS are presented. Recursive forms are derived by decomposing the branch metric computation while breaking down the entire path metric yields nonrecursive forms. The final architecture casts the detection problem into a signal space context in which the observation space is partitioned into decision regions. These structures are presented and evaluated in the context of an analog very large scale integration (VLSI) implementation. Compared to a direct mapping to hardware of the original algorithm, these alternative schemes offer reduced power consumption and/or increased data rate.
2-18 GHz logarithmic amplification componentry (2002)

Two microwave logarithmic amplifier designs are described. The first is a dual channel extended dynamic range detector logarithmic video amplifier (DLVA) design to cover the 2-18-GHz frequency band. The DLVA was developed to achieve state-of-the-art accuracy over a 65-dB dynamic range, while providing excellent amplitude and phase tracking between the two channels. Amplitude and phase tracking of +or-1 dB and +or-5 degrees , respectively, have been achieved. The second is a successive detection logarithmic amplifier (SDLA) design to cover the 2-6-GHz frequency range. The SDLA was developed to achieve state-of-the-art pulse processing capability. A risetime of 8 ns and a recovery time of 30 ns have been achieved over 70 dB of dynamic range.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Novel benzamides as selective and potent gastric prokinetic agents. 1. Synthesis and structure-activity relationships of N-[(2-morpholinyl)alkyl]benzamides (1990)

With the purpose of obtaining more potent and selective gastric prokinetic than metoclopramide (1), a new series of N-[(2-morpholinyl)alkyl]benzamides (17-52) were synthesized and their gastric prokinetic activity was evaluated by determining effects on the gastric emptying of phenol red semisolid meal and of resin pellets solid meal in rats and mice. The morpholinyl moiety was newly designed after consideration of the side-chain structure of cisapride (2) and produced the desired activity when coupled with the 4-amino-5-chloro-2-methoxybenzoyl group of both metoclopramide and cisapride. Modification of the substituents of the benzoyl group markedly influenced the activity. In particular, 4-amino-N-[(4-benzyl-2-morpholinyl)methyl]-5-chloro-2-methoxybenzamide (17) and the 4-(dimethylamino) and 2-ethoxy analogues (25 and 29) of 17 showed potent and selective gastric prokinetic activity along with a weak dopamine D2 receptor antagonistic activity.
Mechanisms of the Glycaemic Effects of Sulfonylureas (1996)

Sulfonylureas are widely used to treat non-insulin dependent diabetes mellitus. These drugs exert their hypoglycaemic effects by stimulating insulin secretion from the pancreatic beta-cell. Their primary mechanism of action is to close ATP-sensitive K-channels in the beta-cell plasma membrane, and so initiate a chain of events which results in insulin release. Recent studies have shown that the beta-cell ATP-sensitive K-channel is a complex of two proteins: a pore-forming subunit (Kir6.2) and a drug-binding subunit (SUR1) which functions as the receptor for sulfonylureas. This review summarizes recent advances in our understanding of the molecular mechanism of sulfonylurea action, focusing on the relationship between the sulfonylurea receptor and the K-ATP channel. Earlier studies are also re-examined in the light of new findings.
A Broadband Low-Cost Direct-Conversion Receiver Front-End in 90 nm CMOS (2008)

Transistors in aggressively scaled CMOS technologies have f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> greater than 150 GHz, which exceeds requirements for most existing commercial applications below 10 GHz. Excess transistor performance can be traded-off for cost by designing out inductors. This paper presents a prototype which exploits the speed of transistors to design highly integrated broadband receiver front-ends. The inductor-less prototype operates from 2 to 5.8 GHz and dissipates 85 mW at 5 GHz while occupying 0.2 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> active area. It provides 44 dB of gain, 3.4 dB double side band noise figure, 21 dBm in-band IIP3 in the highest gain mode and 15 dB input matching.
<title>Electronic front-end processor for active vision</title> (1992)

We suggest that a `vision front end' processor, or VFE, will be a key element of practical vision systems that perform complex tasks in real time, such as autonomous vehicle driving. The VFE is a specialized image processing device located between the cameras and the main vision computer. Its functions are to isolate critical image data for subsequent attention-based analysis, and to compute attributes of these data that are required by the system in order to respond quickly to objects or events of interest in the scene. We propose a generic architecture for the VFE, and describe a prototype system that has been built in custom hardware. We show that a compact device can serve multiple vision modalities, including pattern, motion, and stereo vision.
El discurso como acción social (2004)

El abordaje del discurso como acción social, se presenta como forma de habilitar nuevos caminos en la reconstrucción de acontecimientos, mostrando tanto las estructuras del lenguaje como la ideología que compromete a los actores sociales de un momento determinado.
A New Framework for Credit Card Transactions Involving Mutual Authentication between Cardholder and Merchant (2011)

Electronic Commerce (e-Commerce) and ease in the onsite transactions have led to the exponential growth in the acceptance of credit cards among consumers of all the sections. But despite their remarkable advantages, consumers are still reluctant in their use, especially for online transactions and reason being the increasing credit card fraud rate. A number of security models have been proposed and deployed for secure online transactions but the sharing of sensitive credit card data over the Internet has made online transactions vulnerable to threats. In this paper, we discuss and analyze the current developments in online authentication procedures including biometrics, one-time-password systems and use of mobile device and Public Switched Telephone Network for cardholder authentication. Then we propose a complete new framework for both onsite and online (Internet shopping) credit card transactions. This framework is more secure, robust, enhances user privacy and does not involve the deployment of special hardware systems at the customer's site.
A note on information organization and storage (1973)

Since the logical structure of a data base can be represented by a tree or graph, it is quite natural for us to view the process of designing a data base as that of constructing a tree or a graph. A general method for constructing such a tree or graph is provided. There are three important elements in this general construction method; namely, a set of binary relations, an algorithm for constructing subsets of a set, and an algorithm for selecting an element from the given set of objects. The use of different relations and algorithms results in different information structures, as list, tree, ring, etc. Thus the problem of information organization and storage is reduced to that of defining relations and formulating algorithms under a given set of constraints. The results presented may be valuable to designers as useful design concepts, and may serve as a basis for developing a formal theory on the subject.
Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast (2015)

The structural diversity and biological activities of fungal indole diterpenes (IDTs) are generated in large part by the IDT cyclases (IDTCs). Identifying different IDTCs from IDT biosynthetic pathways is therefore important toward understanding how these enzymes introduce chemical diversity from a common linear precursor. However, IDTCs involved in the cyclization of the well-known aflavinine subgroup of IDTs have not been discovered. Here, using Saccharomyces cerevisiae as a heterologous host and a phylogenetically guided enzyme mining approach, we combinatorially assembled IDT biosynthetic pathways using IDTCs homologues identified from different fungal hosts. We identified the genetically standalone IDTCs involved in the cyclization of aflavinine and anominine and produced new IDTs not previously isolated. The cyclization mechanisms of the new IDTCs were proposed based on the yeast reconstitution results. Our studies demonstrate heterologous pathway assembly is a useful tool in the reconstitution of unclustered biosynthetic pathways.
FACE: A Firewall Analysis and Configuration Engine (2005)

Firewalls play a critical role in protecting networks and enforcing security policies. Traditionally, firewalls have been deployed at an organization's periphery to protect it from Internet traffic. Today, however, this model no longer holds true as organizations try to safeguard themselves against other types of threats. This has led to the advent of the distributed firewall where potentially every router or end-host can run a firewall. As it is, firewalls are extremely hard to analyze and configure correctly due to complexities of network topology, routing, and administrative issues. Distributed firewalls make the situation even worse since there are multiple firewalls. This paper describes FACE - a tool that helps in analysis and configuration of distributed firewalls. Using FACE, administrators can automatically generate and analyze configurations for all firewalls in the network by specifying the filtering policy and a threat model in which a distributed firewall must provide defense against spoofed traffic from specified nodes in a network.
Glycobiology of schistosomiasis (1996)

Schistosomiasis is a helminthic parasitic disease that results in a wide-ranging pathology in the approximately 200 million infected people worldwide. Much of the immunity to the parasite is directed against carbohydrate determinants in both glycoproteins and glycolipids from the adult worms and their eggs. Circulating glycoproteins derived from the parasite may be diagnostic for the disease. Recent studies of the structures of schistosome-derived glycoconjugates reveal that they exhibit several interesting and novel motifs. Many schistosome glycans are rich in fucose and devoid of sialic acid. It is surprising that some of the fucosylated schistosome glycans contain the Lewis x (Le(x)) antigen that is also found on human leukocytes and other tissues. These Le(x)-containing glycans elicit autoantibodies, and the glycans may affect lymphocyte functions. This review highlights recent progress in schistosome research in terms of structure, function, and biosynthesis of glycoconjugates. It is hoped that the deeper understanding being gained about glycoconjugates will foster innovative new strategies for lessening the mortality and morbidity caused by these parasites.
Synthesis of a TMC-95A Ketomethylene Analogue by Cyclization via Intramolecular Suzuki Coupling (2003)

[structure: see text] A TMC-95A analogue extended at the C-terminus with NlePsi[COCH(2)]Gly-Ala-Ala-NH(2) was synthesized via side-chain cyclization of the linear precursor by a Suzuki cross-coupling reaction in solution to analyze the effect of additional P' residues on the inhibitory potency against yeast proteasome.