gebhart/patrepeval huggingface dataset:
[Xanthine oxidase activity of thymocytes in lymphocytolytic effect of hypoxanthine]. (1990)

Destruction of thymocytes, caused by incubation with hypoxanthine, was decreased distinctly after addition of allopurinol as shown by eosin staining. Lymphocytolytic effect of hypoxanthine was accompanied by considerable activation in thymocytes of endogenous xanthine oxidase, which was measured by superoxide anion production; allopurinol decreased the enzyme activity. Enzymatic activity of nucleases participating in degradation of chromatin appears to be a component of prooxidant enzymatic systems of cell.
Efficient Photocurrent Generation in Novel Self-Assembled Multilayers Comprised of [60]Fullerene−Cationic Homooxacalix[3]arene Inclusion Complex and Anionic Porphyrin Polymer (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTEfficient Photocurrent Generation in Novel Self-Assembled Multilayers Comprised of [60]Fullerene−Cationic Homooxacalix[3]arene Inclusion Complex and Anionic Porphyrin PolymerAtsushi Ikeda, Tsukasa Hatano, Seiji Shinkai, Tsuyoshi Akiyama, and Sunao YamadaView Author Information Department of Chemistry & Biochemistry, Graduate School of Engineering, Kyushu University, Fukuoka 812-8581, Japan TOREST, Japan Science and Technology Corporation (JST) Cite this: J. Am. Chem. Soc. 2001, 123, 20, 4855–4856Publication Date (Web):April 26, 2001Publication History Received29 January 2001Published online26 April 2001Published inissue 1 May 2001https://pubs.acs.org/doi/10.1021/ja015596khttps://doi.org/10.1021/ja015596krapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views1226Altmetric-Citations169LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Absorption,Electrodes,Monolayers,Photonics,Vesicles Get e-Alerts
Hyaluronate distribution in the regenerating retinal pigment epithelium of the rabbit: A study using confocal laser scanning microscopy (1994)

The distribution of hyaluronate (HA) in regenerating retinal pigment epithelium (RPE) of the rabbit was examined using immunohistochemistry and confocal laser scanning microscopy. The goal was to determine if there is a correlation between differentiation and HA expression, like that seen in developing tissues, where HA accumulates and then disappears as the tissue matures. In normal RPE cells HA is associated mainly with the apical surface. In regenerating RPE (produced by i.v. injection of sodium iodate to damage the epithelium, regeneration arising from spared cells), HA exhibits a patchy distribution among the more immature cells and is especially prominent where they overlap or pile up on each other. Where cells are more mature and form a compact monolayer of cells, HA is expressed mainly on the apical surface, as in normal RPE. The accumulation of HA among the more immature cells in the regenerating epithelial sheet supports the hypothesis that HA influences differentiation by suppressing cell-cell associations until the proper time for their formation.
Controlled Release of Insect Sex Pheromones from a Natural Rubber Substrate (1991)

A mechanistic model encompassing the factors controlling evaporation rates of pheromones from rubber septa was developed. The model correctly predicted the effect of dose, time, chemical structure, temperature and air speed on evaporation rates. Evaporation rates were first order, and the logarithms of the half-lives were directly proportional to the number of carbon atoms in a homologous series and for a specific compound to the reciprocal of absolute temperature. Also, evaporation rates were directly proportional to air speed. Half-lives depended on thermodynamic relationships and there was an approximate additivity of thermodynamic parameters, making it possible to estimate half-lives and therefore evaporation rates of a large number of compounds at any temperature from a few parameters. There are limitations on uses of natural rubber as a controlled release substrate for conjugated dienes, aldehydes, and certain crystalline compounds. Natural rubber septa are useful for monitoring insect flight activity, for insect behavioral studies, and have potential in control programs based on mating disruption.
A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids (2014)

This study reports on a microfluidic platform on which single multicellular spheroids from malignant pleural mesothelioma (MPM), an aggressive tumor with poor prognosis, can be loaded, trapped and tested for chemotherapeutic drug response. A new method to detect the spheroid viability cultured on the microfluidic chip as a function of the drug concentration is presented. This approach is based on the evaluation of the caspase activity in the supernatant sampled from the chip and tested using a microplate reader. This simple and time-saving method does only require a minimum amount of manipulations and was established for very low numbers of cells. This feature is particularly important in view of personalised medicine applications for which the number of cells obtained from the patients is low. MPM spheroids were continuously perfused for 48 hours with cisplatin, one of the standard chemotherapeutic drugs used to treat MPM. The 50% growth inhibitory concentration of cisplatin in perfused MPM spheroids was found to be twice as high as in spheroids cultured under static conditions. This chemoresistance increase might be due to the continuous support of nutrients and oxygen to the perfused spheroids.
Graphical configuration programming (1989)

The structural description, construction, and evolution of software systems using the Conic graphs environment are discussed. The configuration programming concepts embodied in conic are described and illustrated by the example of a patient monitoring system. The characteristics of the ConicDraw graphic workstation are examined. Browsing and animation extensions are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Rank-One Matrix Pursuit for Matrix Completion (2014)

Low rank matrix completion has been applied successfully in a wide range of machine learn-ing applications, such as collaborative filtering, image inpainting and Microarray data imputa-tion. However, many existing algorithms are not scalable to large-scale problems, as they involve computing singular value decomposition. In this paper, we present an efficient and scalable algo-rithm for matrix completion. The key idea is to extend the well-known orthogonal matching pur-suit from the vector case to the matrix case. In each iteration, we pursue a rank-one matrix ba-sis generated by the top singular vector pair of the current approximation residual and update the weights for all rank-one matrices obtained up to the current iteration. We further propose a novel weight updating rule to reduce the time and storage complexity, making the proposed al-gorithm scalable to large matrices. We establish the linear convergence of the proposed algorithm. The fast convergence is achieved due to the pro-posed construction of matrix bases and the es-timation of the weights. We empirically evalu-ate the proposed algorithm on many real-world large-scale datasets. Results show that our al-gorithm is much more efficient than state-of-the-art matrix completion algorithms while achieving similar or better prediction performance.
Partial Hydrogenation of Alkynes to <i>cis</i>‐Olefins by Using a Novel Pd<sup>0</sup>–Polyethyleneimine Catalyst (2008)

Partial hydrogenation: Various mono- and disubstituted alkynes were partially hydrogenated to give cis-olefins with high selectivity using a 5 % Pd0–polyethyleneimine complex as a catalyst without additives (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2111/2008/z800535_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Cationic niosomes composed of spermine-based cationic lipids mediate high gene transfection efficiency (2012)

Non-ionic surfactant-based vesicles (niosomes) composed of non-ionic surfactants (i.e., Tween and Span) and cholesterol were formulated, and their turbidity and particle size assayed. The most appropriate niosomes formulation was mixed with novel synthesized spermine-based cationic lipids to prepare cationic niosomes that could act as gene carriers. Factors affecting gene transfection and cell viability including differences in the acyl chain length (C14, C16 and C18) of cationic lipids and the weight ratio of niosomes to DNA were evaluated on a human cervical carcinoma cell line (HeLa cells) using pDNA encoding green fluorescent protein (pEGFP-C2). The morphology, size and charge of the niosomes were also characterized, and a gel retardation assay to determine complex formation was performed. The results revealed that the transfection efficiency of the Span 20-niosomes was the highest for the spermine-C14 formulation and decreased as follows: spermine-C14 > spermine-C16 > spermine-C18. In addition to the highest transfection efficiency, there was also no serum effect on transfection efficiency of the spermine-C14 niosomes at a weight ratio of 10. This formulation was safe in vitro and had good physical stability for at least 1 month at 4°C. In conclusion, the cationic niosomes may constitute a good alternative carrier for gene transfection.
Perspectives of the Farm Cooperative Operating Environment: Directors and Managers (2002)

Farmer cooperative managers and directors were contracted to determine their perspectives of the cooperative environment. Special emphasis was given to assessing their perceptions of division of responsibility between management and the board of directors, the importance of cooperative principles to the operation and success of their firms, and their knowledge and capabilities in business decision-making and financial analysis. Both groups showed strong support for most traditional cooperative principles and performance scores were consistent for finance and decision making areas. However, managers showed they understood and carried out their areas of responsibility better than directors. Self-assessments were higher for managers and consistent with performance measures. Additional training in financial analysis, strategic planning, and proper roles for managers and directors seemed warranted.
A micro method for the separation and determination of polysaccharides by zone electrophoresis (1956)

The separation and determination of the individual polysaccharides present in a mixture is a difficult and tedious process which often can only be carried out on the macro-scale. Northcote (1954) has used electrophoresis in borate buffer in the Tiselius apparatus as a method for determining the minimum number of constituents of a mixture, but the recovery of the materials behind each boundary, which is necessary if the monosaccharide consti- tuents of each component are to be studied, is difficult. This difficulty might be overcome if the electrophoresis could be carried out on some form of strip support, and the present work describes such a technique.
A Strongly Coupled Graphene and FeNi Double Hydroxide Hybrid as an Excellent Electrocatalyst for the Oxygen Evolution Reaction (2014)

Cost-effective electrocatalysts for the oxygen evolution reaction (OER) are critical to energy conversion and storage processes. A novel strategy is used to synthesize a non-noble-metal-based electrocatalyst of the OER by finely combining layered FeNi double hydroxide that is catalytically active and electric conducting graphene sheets, taking advantage of the electrostatic attraction between the two positively charged nanosheets. The synergy between the catalytic activity of the double hydroxide and the enhanced electron transport arising from the graphene resulted in superior electrocatalytic properties of the FeNi-GO hybrids for the OER with overpotentials as low as 0.21 V, which was further reduced to 0.195 V after the reduction treatment. Moreover, the turnover frequency at the overpotential of 0.3 V has reached 1 s(-1), which is much higher than those previously reported for non-noble-metal-based electrocatalysts.
Fibrillar &#946;-Amyloid Impairs the Late Phase of Long Term Potentiation (2006)

Synaptic dysfunction is involved in early stages of Alzheimer's disease (AD). Amyloid-beta peptides (Abeta), a neuropathologic hallmark of the disease, have been shown to alter synaptic function. Given that Abeta is present in different forms including monomeric, oligomeric and fibrillar species, we have investigated whether fibrillar Abeta impairs synaptic function. Here we report that a synthetic fibrillar form of Abeta impairs the late protein-synthesis dependent phase of LTP without affecting the early protein-synthesis independent phase. These findings add to previous reports that Abeta oligomers are highly toxic to cells and might cause synaptic dysfunction, and suggest that a therapeutic intervention in AD should include the use of drugs inhibiting and disassembling fibril formation in addition to drugs inhibiting oligomers formation.
Expression of an <i>ASCL2</i> related stem cell signature and <i>IGF2</i> in colorectal cancer liver metastases with 11p15.5 gain (2010)

With unprecedented resolution a striking conservation of genomic alterations was demonstrated in liver metastases, suggesting that metastasis typically occurs after the pCRC has fully matured. In addition, we characterised a subset of liver metastases with an ASCL2-related stem-cell signature likely to affect metastatic behaviour of tumour cells.
Realistic efficiency of coupling light from GaAs laser diodes into parabolic-index optical fibres (1978)

More than 500 laser diodes have been coupled to graded-index fibres using microscopic glass beads for a proper injection into the fibre core. The coupling efficiencies have a good reproducibility and a high average value.
Cerebellar lipid differences between R6/1 transgenic mice and humans with Huntington’s disease (2010)

Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by motor, psychiatric, and cognitive abnormalities. In this present study, we tested whether abnormal motor behavior in a mouse model of HD, the R6/1 transgenic (Tg) mice, was associated with changes in cerebellar lipid composition and gene expression. We report altered motor behavior, which was associated with abnormal expression of glycosyltransferase genes in the cerebellum of R6/1 Tg mice. Cerebellar wet weight and total ganglioside concentration was significantly lower in R6/1 Tg mice than in wild-type (Wt) mice. Furthermore, the Purkinje cell-enriched ganglioside LD1 and the granule cell-enriched ganglioside GD1a were significantly lower in R6/1 Tg mice than in Wt mice. The myelin-enriched lipid sulfatides was also reduced in the cerebellum of R6/1 Tg mice. In contrast to the R6/1 Tg mice, total cerebellar ganglioside concentration did not differ between HD and control subjects. However, expression of several cerebellar glycosyltransferases genes was significantly less in HD subjects than in control subjects. Our findings indicate that the R6/1 Tg mice have severe cerebellar glycosphingolipid (GSL) abnormalities that may account, in part, for their abnormal motor behavior. Although the cerebellar lipid abnormalities found in the R6/1 Tg mice were not found in these HD subjects, the R6/1 Tg mice may be useful for evaluating the role of GSLs in cerebellar development.
Resistive-gate CTD area image sensor (1978)

The resistive gate sensor concept that combines high functional density, good blue sensitivity and an effective anti-blooming operating, will be described. A super-8 format 300 × 200 element sensor has been realized.
A Comparison of MCC and CEN Error Measures in Multi-Class Prediction (2012)

We show that the Confusion Entropy, a measure of performance in multiclass problems has a strong (monotone) relation with the multiclass generalization of a classical metric, the Matthews Correlation Coefficient. Analytical results are provided for the limit cases of general no-information (n-face dice rolling) of the binary classification. Computational evidence supports the claim in the general case.
Workflow analysis method using activity‐based costing management with information allocation (2004)

Abstract In a workflow information processing system, usually optimization of the workflow overall and design of each process which comprises the workflow are performed separately. As a result, inefficient procedures and duplication of processes remain in the workflow. In order to resolve this problem, the authors apply activity‐based costing management (ABM), a managerial accounting method, to workflow design in this paper. Note, however, that under a conventional ABM which allocates cost and time, sufficient analytical results cannot be obtained. Thus, in this paper the authors propose a new analysis method which allocates data items in the system. Under this method, a data item in the system or an operator process is defined as “information,” and then classified as value‐added information or non‐value‐added information depending on whether or not it contributes to the manufacturing resource produced by the system. The authors apply their proposed method to the workflow of the research paper manuscript system at the Institute of Electronics, Information, and Communication Engineers and confirm that it reduces the number of steps in the workflow by 12%. © 2004 Wiley Periodicals, Inc. Electron Comm Jpn Pt 3, 87(8): 55–65, 2004; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/ecjc.20087
Two genes in Saccharomyces cerevisiae encode a membrane-bound form of casein kinase-1. (1992)

Two cDNAs encoding casein kinase-1 have been isolated from a yeast cDNA library and termed CKI1 and CKI2. Each clone encodes a protein of approximately 62,000 Da containing a highly conserved protein kinase domain surrounded by variable amino- and carboxy-terminal domains. The proteins also contain two conserved carboxy-terminal cysteine residues that comprise a consensus sequence for prenylation. Consistent with this posttranslational modification, cell fractionation experiments demonstrate that intact CKI1 is found exclusively in yeast cell membranes. Gene disruption experiments reveal that, although neither of the two CKI genes is essential by itself, at least one CKI gene is required for yeast cell viability. Spores deficient in both CKI1 and CKI2 fail to grow and, therefore, either fail to germinate or arrest as small cells before bud emergence. These results suggest that casein kinase-1, which is distributed widely in nature, plays a pivotal role in eukaryotic cell regulation.
Occurrence of a trypsin inhibitor in eggplant exocarps. (1975)

A trypsin inhibitor was extracted from eggplant exocarps with several buffers. The 0.1M acetate buffer, pH 5.5, extract had the highest specific activity. The crude inhibitor, obtained by heat treatment and salting-out from the acetate buffer extract, contained 4.5 nitrogen and 22.6% hexose. Isoelectrofocusing demonstrated that this crude inhibitor in the eggplant exocarps was composed of at least three forms, one of which differed in its isoelectric point. The form at pH 4.7 had the strongest activity. The molecular weights of these inhibitors were estimated to be between 5.000-10.000 by gel filtration.
Synthesis and Antimicrobial Evaluation of Some New Thiophene Derivatives (2010)

2-(2-Cyano-acetylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxamide(3) was used as starting material for synthesis of 4-thiazolidinone, thiazolidine, and thiophene derivatives 6, 7a, b, and 8a, b, respectively. Thiocarbomyl derivative 5, 4-thizolidinone 9, and thioxothiazolidine 10 were obtained from reaction of 3 with thioglycolic acid and phenyl isothiocyanate/sulfur, respectively. Condensation of 3 with selected cyclic ketones and aromatic aldehydes yielded the arylidine derivatives 11a, b and 13, respectively. Refluxing of 11a, b with sulfur and morpholine yielded the thiophene derivatives 12a, b, respectively. Diazocoupling of compound 3 withp-tolyl diazonium chloride yielded the hydrazone derivative 14. The newly synthesized compounds were characterized by infrared, 1H NMR, and mass spectral studies. Representative compounds of the synthesized product were tested and evaluated as antimicrobial agents. Compound 12b gives very high antimicrobial activity against Ampicillin.
Cytoplasmic interactions between decay-accelerating factor and intercellular adhesion molecule-1 are not required for coxsackievirus A21 cell infection (2000)

Coxsackievirus A21 (CAV-21) employs a cell receptor complex of decay-accelerating factor (DAF) and intercellular adhesion molecule-1 (ICAM-1) for cell infectivity. In this study, the nature of potential extra- and/or intracellular interactions between DAF and ICAM-1 involved in picornaviral cell entry was investigated. Firstly, it was shown that intracellular interplay between DAF and ICAM-1 is not required for CAV-21 infection, as CAV-21 lytic infection mediated via the DAF/ICAM-1 receptor complex is not inhibited by replacement of the transmembrane and cytoplasmic domains of ICAM-1 with those from an unrelated cell surface molecule, CD36. By immunoprecipitation, chemical cross-linking and picornaviral binding assays, the existence of a close spatial association between DAF and ICAM-1 on the surface of ICAM-1-transfected RD cells was confirmed. Furthermore, it was shown that potential extracellular DAF/ICAM-1 interactions are likely to occur in an area on or proximal to DAF SCR3 and may influence the route of CAV-21 cell entry.
Design Patterns for Teaching Type Checking in a Compiler Construction Course (2007)

A course in compiler construction seeks to develop an understanding of well-defined fundamental theory and typically involves the production of a language processor. In a graduate degree in software engineering, the development of a compiler contributes significantly to the developer's comprehension of the practical application of theoretical concepts. Different formal notations are commonly used to define type systems, and some of them are used to teach the semantic analysis phase of language processing. In the traditional approach, attribute grammars are probably the most widely used ones. This paper shows how object-oriented design patterns represented in unified modeling language (UML) can be used to both teach type systems and develop the semantic analysis phase of a compiler. The main benefit of this approach is two-fold: better comprehension of theoretical concepts because of the use of notations known by the students (UML diagrams), and improvement of software engineering skills for the development of a complete language processor.