gebhart/patrepeval huggingface dataset:
Analysis of TCP/IP for high performance parallel implementations (2003)

An analysis of potential parallelism in TCP/IP is presented for two purposes. First, it is used as a basis for an implementation on a multiprocessing platform. Second, it reveals the areas where protocol modifications and/or tuning would yield more efficient implementations on multiprocessors. The focus is on the analysis, and detailed dependence graphs among the atomic TCP/IP protocol functions are presented. No specific implementation design is shown, since this highly depends on the particular hardware chosen.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Computer-aided diagnosis in chest imaging: How to improve performance and avoid reinventing the wheel (2010)

Computer-aided diagnosis (CAD) is a rapidly expanding area of medical image analysis that aims to help clinicians in making a proper diagnosis by, for example, detecting abnormalities, classifying and diagnosing these, and quantifying the spread of disease. The largest efforts in CAD, both commercially and academically, have been aimed at mammography, but chest imaging is the second major area.
Regulatory Review of Novel Therapeutics — Comparison of Three Regulatory Agencies (2012)

For novel therapeutic agents approved between 2001 and 2010, the FDA reviewed applications involving novel therapeutics more quickly, on average, than did the EMA or Health Canada, and the vast majority of these new therapeutic agents were first approved for use in the United States. (Funded by the Pew Charitable Trusts.).
Radiation-induced changes in bone perfusion and angiogenesis (1998)

Radiation induces a chronic antiangiogenic effect contributing to reduced limb growth. At 33 weeks the antiangiogenesis was not associated with local soft tissue elevations of TNF, IFN, or TGFbeta. Radiation toxicity to bone is alleviated by bFGF therapy suggesting that powerful locally-acting antiangiogenic mechanisms are involved. We postulate that the increased LDF of the contralateral tibia is due to circulating angiogenesis factors that are elevated to compensate for the radiation-induced antiangiogenesis.
Compression of Phase-Only Holograms with JPEG Standard and Deep Learning (2018)

It is a critical issue to reduce the enormous amount of data in the processing, storage and transmission of a hologram in digital format. In photograph compression, the JPEG standard is commonly supported by almost every system and device. It will be favorable if JPEG standard is applicable to hologram compression, with advantages of universal compatibility. However, the reconstructed image from a JPEG compressed hologram suffers from severe quality degradation since some high frequency features in the hologram will be lost during the compression process. In this work, we employ a deep convolutional neural network to reduce the artifacts in a JPEG compressed hologram. Simulation and experimental results reveal that our proposed “JPEG + deep learning” hologram compression scheme can achieve satisfactory reconstruction results for a computer-generated phase-only hologram after compression.
OUT‐PATIENT CERVICAL CRYOSURGERY (1972)

Summary Cryosurgery is an easy, safe and highly acceptable means of treating chronic cervicitis and erosions. One hundred and thirty‐two patients were reassessed after cryosurgery had been performed in the out‐patients department without anaesthesia or analgesia: treatment was successful in 125 instances (95 per cent).
Efficient Decomposition of Environmentally Persistent Perfluorocarboxylic Acids by Use of Persulfate as a Photochemical Oxidant (2005)

Photochemical decomposition of persistent perfluorocarboxylic acids (PFCAs) in water by use of persulfate ion (S2O8(2-)) was examined to develop a technique to neutralize stationary sources of PFCAs. Photolysis of S2O8(2-) produced highly oxidative sulfate radical anions (SO4-), which efficiently decomposed perfluorooctanoic acid (PFOA) and other PFCAs bearing C4-C8 perfluoroalkyl groups. The major products were F- and CO2; also, small amounts of PFCAs with shorter than initial chain lengths were detected in the reaction solution. PFOA at a concentration of 1.35 mM (typical of that in untreated wastewater after an emulsifying process in fluoropolymer manufacture) was completely decomposed by a photochemical system with 50 mM S2O8(2-) and 4 h of irradiation from a 200-W xenon-mercury lamp. The initial PFOA decomposition rate was 11 times higherthan with photolysis alone. All sulfur-containing species in the reaction solution were eventually transformed to sulfate ions by this method. This method was successfully applied to the decomposition of perfluorononanoic acid contained in a floor wax solution.
THE ALIGNMENT OF INFORMATION TECHNOLOGY WITH INTELLIGENTTRANSPORT SYSTEMS (2008)

This article aims to present the importance of alignment
					of information technology with intelligent transport systems for
					the Traffic Demand Management. The congestion are some of the major
					problems that happen in the main avenues of the big cities, but
					with the use of some techniques of Intelligent Transport Systems
					through the use of variable information, or PMVs (Variable Message
					Panels), which has the function of disseminating updated in real
					time information to users of the route, this technology can be an
					important tool to alleviate the inconvenience caused by the traffic
					congestions of Avenida Brasil in Campo Grande in Rio de Janeiro.
					This work is based on the review of existing literature, as well as
					information obtained through interviews with taxi drivers who ride
					daily on Avenida Brasil.
Upregulated expression of human neutrophil peptides 1, 2 and 3 (HNP 1-3) in colon cancer serum and tumours: a biomarker study (2005)

HNP 1-3 may serve as blood markers for colon cancer in combination with other diagnostic tools. We propose that HNP 1-3 are carried into the bloodstream by attaching to high mass plasma proteins in the tumour microenvironment. We discuss the effect of HNP 1-3 on tumour progression.
Gas-phase characterization of silicon nanoclusters produced by laser pyrolysis of silane (1999)

Silicon clusters and nanocrystals containing up to several thousand atoms per cluster have been generated by pulsed ${\mathrm{CO}}_{2}$-laser-induced decomposition of ${\mathrm{SiH}}_{4}$ in a flow reactor. By introducing a conical nozzle into the reaction zone, the nascent clusters are extracted into a molecular beam apparatus where they are analyzed with a time-of-flight mass spectrometer. Compared to the well-established laser vaporization method, this technique is capable of producing considerably larger silicon clusters with diameters in the nanometer size regime. A time-of-flight study of the neutral silicon clusters has shown that the velocity of the particles strongly depends on their size. This feature enables one, by introducing a chopper into the cluster beam, to considerably reduce the size distribution and to perform experiments with quasi-size-selected neutral clusters. An investigation of the fragmentation behavior of the ionized silicon clusters as a function of the fluence of the ionizing ArF excimer laser reveals that intermediate-size ${\mathrm{Si}}_{n}$ clusters $(n=22\ensuremath{-}100)$ fragment by fission, yielding ${\mathrm{Si}}_{6}^{+}\mathrm{}\ensuremath{-}{\mathrm{Si}}_{11}^{+},$ while nanometric silicon clusters evaporate single ${\mathrm{Si}}^{+}$ and ${\mathrm{Si}}_{2}^{+}$ ions if the fluence of the ionizing laser is large enough. At the same time, multiply charged nanoclusters are observed. The probability of multiple ionization scales with the size of the nanoclusters.
Dynamical behavior of rate-based flow control mechanisms (1990)

Flow control mechanisms are essential for the efficient and stable operation of store-and-forward networks. New transport protocols, such as VMTP and NETBLT, intend to use rate-based flow control. We present a model in which a network with connections subject to rate-based flow control is considered as a dynamical system, i.e., a set of coupled differential equations. We consider two scenarios: (1) a single connection over a long delay path involving a bottleneck; and (2) two connections with different roundtrip delays that share a common bottleneck. For a recently proposed control scheme, we obtain closed-form solutions for the dynamical model in both transient and steady state regimes, and evaluate appropriate performance measures. We compare our results with those obtained by others using experimental and simulation approaches.
95% Leakage-Reduced FPGA using Zigzag Power-gating, Dual-VTH/VDD and Micro-VDD-Hopping (2005)

Low-power FPGA architecture is proposed based on fine-grained V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> control scheme called micro-V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> -hopping. Four configurable logic blocks (CLB) are grouped into one block where V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> is shared. In the micro-V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> -hopping scheme, V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> of each block is varied between the higher V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DDH</sub> ) and the lower V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DDL</sub> ) spatially and temporally to achieve lower power, while keeping performance undegraded. A level shifter that has less contention is proposed. The FPGA also incorporates Zigzag power-gating scheme, special care has been taken to cope with sneak leakage path problem. The proposed FPGA is fabricated using 035mum CMOS technology together with the conventional fixed-V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> FPGA. Measurement shows that the dynamic power can be reduced by 86% when the required speed is half of the highest speed. Simulation using 90nm CMOS technology shows that a leakage power reduction of 95% can be achieved, when the proposed method is used. Area overhead of the proposed FPGA is 2%
Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5‐fluorouracil (1992)

We determined the effects of organ environment on the response of murine CT-26 colon carcinoma cells to 2 structurally and pharmacologically distinct chemotherapeutic agents. CT-26 cells were injected i.v. (to produce lung lesions), s.c., into the cecal wall, and into the spleen (to produce spleen and liver lesions). Doxorubicin (DXR) at 10 mg/kg, 5-fluorouracil (5-FU) at 20 mg/kg, or saline (control) was injected intravenously on different schedules after tumor-cell implantation. The in vivo responses of the tumors growing in the cecum, spleen, liver, lung and subcutis were compared. Colon carcinomas growing in the subcutis were most sensitive to DXR. Tumors growing in the spleen and cecum were most sensitive to 5-FU and less so to DXR. Tumors in the liver were highly resistant to both drugs, whereas experimental lung metastases were sensitive to 5-FU but resistant to DXR. The differential responses of the tumors to the drugs were not due to drug distribution. The level of protein-kinase-C activity was elevated in the spleen, liver and cecum tumors as compared with s.c. tumors and correlated with the in vivo DXR resistance of the tumor cells. This correlation suggested that organ environment may modulate the chemosensitivity of tumor cells, at least in part, by perturbing signal transduction pathways. Collectively, the data indicate that the organ environment has profound effects on the response of tumor cells to chemotherapy. A molecular understanding of this phenomenon should facilitate the design of more effective systemic chemotherapy for cancer metastases.
Large Scale Synthesis of H<sub>2</sub>B(NH<sub>3</sub>)<sub>2</sub>+BH<sub>4</sub>- and H<sub>3</sub>NBH<sub>3</sub> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLarge Scale Synthesis of H2B(NH3)2+BH4- and H3NBH3S. G. Shore and K. W. BoddekerCite this: Inorg. Chem. 1964, 3, 6, 914–915Publication Date (Print):June 1, 1964Publication History Published online1 May 2002Published inissue 1 June 1964https://pubs.acs.org/doi/10.1021/ic50016a038https://doi.org/10.1021/ic50016a038research-articleACS PublicationsRequest reuse permissionsArticle Views1174Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Neue Orchideen des malaiischen Archipels, II (1908)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
ACE: Architecture for collaborative environments (2010)

With the advent of Facebook and Twitter, people are demanding high-performance high-quality online multimedia systems where a large number of users can collaborate with each other. Incorporating these features usually results in the following issues: high bandwidth usage, lower interactivity, higher latency; and often, only low quality compressed multimedia content can be used. In this paper we present the ACE architecture which is implemented in a virtual collaborative environment and tries to overcome the mentioned drawbacks.
Detection of Driver Cognitive Distraction: A Comparison Study of Stop-Controlled Intersection and Speed-Limited Highway (2016)

Driver distraction has been identified as one major cause of unsafe driving. The existing studies on cognitive distraction detection mainly focused on high-speed driving situations, but less on low-speed traffic in urban driving. This paper presents a method for the detection of driver cognitive distraction at stop-controlled intersections and compares its feature subsets and classification accuracy with that on a speed-limited highway. In the simulator study, 27 subjects were recruited to participate. Driver cognitive distraction is induced by the clock task that taxes visuospatial working memory. The support vector machine (SVM) recursive feature elimination algorithm is used to extract an optimal feature subset out of features constructed from driving performance and eye movement. After feature extraction, the SVM classifier is trained and cross-validated within subjects. On average, the classifier based on the fusion of driving performance and eye movement yields the best correct rate and F-measure (correctrate = 95.8 ± 4.4%; for stop-controlled intersections and correct rate = 93.7 ± 5.0%; for a speed-limited highway) among four types of the SVM model based on different candidate features. The comparisons of extracted optimal feature subsets and the SVM performance between two typical driving scenarios are presented.
Genetically Determined Heterogeneity in Hemoglobin Scavenging and Susceptibility to Diabetic Cardiovascular Disease (2003)

A major function of haptoglobin (Hp) is to bind hemoglobin (Hb) to form a stable Hp-Hb complex and thereby prevent Hb-induced oxidative tissue damage. Clearance of the Hp-Hb complex can be mediated by the monocyte/macrophage scavenger receptor CD163. We recently demonstrated that diabetic individuals homozygous for the Hp 2 allele (Hp 2-2) were at 500% greater risk of cardiovascular disease (CVD) compared with diabetic individuals homozygous for the Hp 1 allele (Hp 1-1). No differences in risk by Hp type were seen in individuals without diabetes. To understand the relationship between the Hp polymorphism and diabetic CVD, we sought to identify differences in antioxidant and scavenging functions between the Hp types and to determine how these functions were modified in diabetes. The scavenging function of Hp was assessed using rhodamine-tagged and 125I-Hp in cell lines stably transfected with CD163 and in macrophages expressing endogenous CD163. We found that the rate of clearance of Hp 1-1-Hb by CD163 is markedly greater than that of Hp 2-2-Hb. Diabetes is associated with an increase in the nonenzymatic glycosylation of serum proteins, including Hb. The antioxidant function of Hp was assessed with glycosylated and nonglycosylated Hb. We identified a severe impairment in the ability of Hp to prevent oxidation mediated by glycosylated Hb. We propose that the specific interaction between diabetes, CVD, and Hp genotype is the result of the heightened urgency of rapidly clearing glycosylated Hb-Hp complexes from the subendothelial space before they can oxidatively modify low-density lipoprotein to atherogenic oxidized low-density lipoprotein.
The Transcriptional Targets of Mutant FOXL2 in Granulosa Cell Tumours (2012)

Given that many of the transcriptional targets of mutant FOXL2 are known TGF-β signalling genes, we suggest that deregulation of this key antiproliferative pathway is one way mutant FOXL2 contributes to the pathogenesis of adult-type GCTs. We believe this pathway should be a target for future therapeutic interventions, if outcomes for women with GCTs are to improve.
R2* estimation using “in‐phase” echoes in the presence of fat: The effects of complex spectrum of fat (2012)

R2* mapping uncorrected for spectral complexity of fat contains protocol and fat-dependent errors (lack of robustness) in tissues with high fat content. Accounting for complex fat spectrum improves robustness and accuracy of signal fitting, with modest noise performance loss.
CXC‐chemokine/CXCR2 biological axis promotes angiogenesis <i>in vitro</i> and <i>in vivo</i> in pancreatic cancer (2009)

Angiogenesis is essential for tumor growth and metastasis. Although ELR(+)-CXC-chemokines and their corresponding receptor, CXC-receptor 2 (CXCR2), are known mediators of angiogenesis, little is known about their role in pancreatic cancer (PaCa). The aim of our study was to determine the role of ELR(+)-CXC-chemokine/CXCR2 biological axis in promoting PaCa angiogenesis. We prospectively collected secretin-stimulated exocrine pancreatic secretions (SSEPS) from normal individuals (NP) and PaCa patients. We showed that summed concentrations of ELR(+)-CXC-chemokines in SSEPS from PaCa patients were significantly higher than in those from NP (p = 0.002). We measured ELR(+)-CXC-chemokine levels in supernatants from multiple PaCa cell lines and confirmed that BxPC-3, Colo-357 and Panc-28 had significantly higher expression compared with an immortalized human pancreatic ductal epithelial (HPDE) cell line. After confirming lack of autocrine effects of ELR(+)-CXC-chemokines on PaCa cells (due to absence of CXCR2 expression), we investigated paracrine effects of these chemokines on human umbilical vein endothelial cells (HUVEC). Both recombinant ELR(+)-CXC-chemokines and co-culturing with BxPC-3 significantly enhanced proliferation, invasion, and tube formation of HUVEC (p < 0.05). These biological effects were significantly inhibited by treatment with a neutralizing antibody against CXCR2 (anti-CXCR2 Ab) (p < 0.05). Finally, anti-CXCR2 Ab significantly reduced tumor volume (p < 0.05), Ki-67 proliferation index (p = 0.043) and Factor VIII(+) microvessel density (p = 0.004) in an orthotopic nude mouse PaCa model. Our results show that ELR(+)-CXC-chemokines promote PaCa tumor-associated angiogenesis through CXCR2, suggesting that CXCR2 is an anti-angiogenic target in PaCa.
Carotenoids: potential allies of cardiovascular health? (2015)

Carotenoids are a class of natural, fat-soluble pigments found principally in plants. They have potential antioxidant biological properties because of their chemical structure and interaction with biological membranes. Epidemiologic studies supported the hypothesis that antioxidants could be used as an inexpensive means of both primary and secondary cardiovascular disease (CVD) prevention. In fact, the oxidation of low-density lipoproteins (LDL) in the vessels plays a key role in the development of atherosclerotic lesions. The resistance of LDL to oxidation is increased by high dietary antioxidant intake, so that carotenoids, as part of food patterns such as the Mediterranean diet, may have beneficial effects on cardiovascular health too. Further properties of carotenoids leading to a potential reduction of cardiovascular risk are represented by lowering of blood pressure, reduction of pro-inflammatory cytokines and markers of inflammation (such as C-reactive protein), and improvement of insulin sensitivity in muscle, liver, and adipose tissues. In addition, recent nutrigenomics studies have focused on the exceptional ability of carotenoids in modulating the expression of specific genes involved in cell metabolism. The aim of this review is to focus attention to this effect of some carotenoids to prevent CVD.
Prediction methods for effective resource provisioning in cloud computing: A survey (2018)

Nowadays, most of the companies are shifting from desktop PCs application to cloud based applications deployed on clouds to provide the effective services in the heterogeneous environments. But, in order to survive in such a cloud competitive market,
Identification of Small Molecule Hes1 Modulators as Potential Anticancer Chemotherapeutics (2012)

Hes1 is a key transcriptional regulator primarily controlled by the Notch signaling pathway, and recent studies have demonstrated both an oncogenic and tumor suppressor role for Hes1, depending on the cell type. Small molecules that activate and inhibit Hes1 activity hold promise as future anticancer chemotherapeutics. We have utilized a cell-based dual luciferase assay to identify modulators of Hes1 expression in a medium-throughput format. A modest screen was performed in HCT-116 colon cancer cell lines, and two small molecules were identified and characterized as Hes1 regulators. Compound 3 induced Hes1 expression and exhibited anticancer effects in pulmonary carcinoid tumor cells, a cell type in which the upregulated Notch/Hes1 signaling plays a tumor suppressive role. Treatment of HCT-116 cells with compound 12 resulted in Hes1 downregulation and antitumor effects.