gebhart/patrepeval huggingface dataset:
The amide nitrogen-15 chemical shift tensors of four peptides determined from carbon-13 dipole-coupled chemical shift powder patterns (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe amide nitrogen-15 chemical shift tensors of four peptides determined from carbon-13 dipole-coupled chemical shift powder patternsTerrence G. Oas, Cynthia J. Hartzell, Frederick W. Dahlquist, and Gary P. DrobnyCite this: J. Am. Chem. Soc. 1987, 109, 20, 5962–5966Publication Date (Print):September 1, 1987Publication History Published online1 May 2002Published inissue 1 September 1987https://pubs.acs.org/doi/10.1021/ja00254a011https://doi.org/10.1021/ja00254a011research-articleACS PublicationsRequest reuse permissionsArticle Views286Altmetric-Citations147LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature (2016)

Janus kinase family (JAKs) has recently attracted the attention of many researchers, and several JAK inhibitor drugs have been developed targeting different members of the JAK family. Tofacitinib and ruxolitinib are US FDA approved drugs in this family for rheumatoid arthritis and myeloproliferative diseases, respectively. Dysregulation of JAK/STAT pathway is also involved in many skin diseases, specifically inflammatory disorders. The JAK/STAT signaling pathway and its involvement in skin diseases are overviewed in this study. We also review clinical studies of JAK inhibitors in field of dermatology, including psoriasis, atopic dermatitis, alopecia areata and vitiligo. Although the available evidence shows promising results, it is still too early to draw a firm conclusion about the place of these drugs in dermatological treatment.
Controlled Flaws in Ceramics: A Comparison of Knoop and Vickers Indentation (1983)

Application of indentation fracture analysis to Knoop and Vickers indentation is examined, with particular emphasis on determining the limitations of the point force representation for the residual stress field. Deviation from the point force approximation is insignificant for crack‐size/plastic‐zone‐size ratios 1.3. The Vickers deformation/fracture configuration in brittle materials invariably conforms to this requirement, whereas the Knoop configuration does not (except at very high indentation loads). However, stable crack growth during a failure test extends the crack sufficiently that the strength degradation for both types of indentation is well described by the point force approximation.
Synergistic effect of perfluorochemicals on BCNU chemotherapy (1982)

✓ In a study of the effect of adding perfluorochemicals to BCNU chemotherapy, 7 × 105 9L tumor cells were implanted in the right cerebral hemisphere of Fischer 344 rats weighing about 100 gm each. On the 7th day after implantation, rats were given BCNU or Fluosol-43 (perfluorochemical artificial blood substitute), or a combination of the two, and the therapeutic effects of these treatments were studied. Mean survival time of control animals was 15.23 days ± 2.84 days (standard deviation); in the group treated with Fluosol-43 and kept in an oxygen chamber (95% O 2 , 5% CO 2 ), survivial time was 15.30 ± 2.11 days. The BCNU treatment alone and BCNU in rats kept in an oxygen chamber prolonged the mean survival time to 20.90 ± 3.80 days and 21.10 ± 2.14 days, respectively. Survival times in rats receiving BCNU plus Fluosol and breathing normal air, BCNU plus dextran-40 and breathing normal air, and BCNU plus dextran-40 in an oxygen chamber were 21.20 ± 2.63 days, 22.90 ± 1.52 days, and 22.20 ± 1.79 days, respectively. On the other hand, treatment with BCNU plus Fluosol-43 in rats kept in an oxygen chamber resulted in a significant increase of mean survival time of 32.27 ± 4.80 days (p < 0.005). From these results, it seems likely that Fluosol-43 with oxygen might have a synergistic effect for BCNU chemotherapy in malignant brain tumors.
Surface Reaction of C<sub>60</sub>with Atomic Hydrogen: Formation of a Protecting Hydrocarbon Layer (2005)

Abstract The interaction of a single domain C60/InP(0 0 1)‐(2×4) film during exposure to atomic hydrogen was investigated. At low hydrogen dosing, a high reactivity of the C60 molecules was detected. Presumably, the cracking of fullerene cages follows from a fast destruction of the molecular order. High dosing leads, by chemical modification, to the formation of a stable coverage of hydrocarbons, which is promising for future technological applications.
Robust multivariable feedback design for an extractive distillation column (1994)

In this paper, multivariable quantitative feedback theory (QFT) techniques are used to synthesize a robust feedback system for an extractive distillation column with a vaporous sidestream. The simplified state space model of Gilles and Retzbach (1983) for an extractive distillation column exhibiting sharp temperature profiles is adopted here. Large uncertainty of +20% is assumed in three key matrix elements of this model. The feedback design problem is to find the controller and prefilter matrices such that the stated tracking specifications are met, over the entire range of model parametric uncertainty. The fourth MIMO QFT technique of Yaniv and Horowitz (1986) is used to solve the design problem. The design is verified through extensive simulations in both frequency and time domains, for several plants picked from the plant uncertainty set. In all cases, the results obtained are quite satisfactory.
Determination of the acidity of Lewis acids (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of the acidity of Lewis acidsPierre Laszlo and Michelle TestonCite this: J. Am. Chem. Soc. 1990, 112, 24, 8750–8754Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/ja00180a017https://doi.org/10.1021/ja00180a017research-articleACS PublicationsRequest reuse permissionsArticle Views2657Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inducing a large second-order optical nonlinearity in soft glasses by poling (1998)

Electrothermal poling of soft glasses (soda lime and borosilicate glass) at relatively high currents led to the creation of a second-order optical nonlinearity. The second-harmonic generation efficiency decays in time, and the decay rate can be accelerated by exposure to intense infrared radiation.
Overview of Content Protection Technology for Intelligent Attached Devices (2006)

We previously developed standards for a new type of removable storage device called an "information versatile disk for removable usage" (iVDR/sup /spl trade/1/) as members of the iVDR hard disk drive consortium. The standards cover both the physical and application aspects, but not cover content protection. We have now developed architecture to protect the content recorded on the removable storage device. The architecture focuses on the transfer of the content key and the usage rules. It is pertinent for video recording and playback, and enables time-shift playback of video content without the storage device having to establish distinct secure connections for the import devices and export device.
Fabrication of dense and porous biphasic calcium phosphates: Effect of dispersion on sinterability and microstructural development (2019)

Abstract The particle size distribution of a commercial Mg‐doped hydroxyapatite powder was tailored through two different milling procedures, carried out under wet or dry conditions. Wet milling gave rise to finer particles, with a narrower size distribution. Tailoring the particles size was the key to produce homogeneous gelcast green bodies, as well as fully dense and fine microstructures. In fact, wet‐milled samples achieved full densification and compressive strength of about 300 MPa, five times higher than the values achieved by the dry milled samples. During the calcination treatments, HA progressively decomposed into β‐ and α‐ TCP phases, promoted by the progressive Mg 2+ substitution inside the HA and β‐ TCP lattices. As a result, a biphasic ( HA /β‐ TCP ) calcium phosphate ceramic was successfully obtained. Gelcast macroporous materials were prepared by direct foaming, starting from both milled powders. Highly porous samples (73%‐77% porosity) with a high degree of interconnectivity within pores were successfully produced. However, dry milled‐foamed materials were characterized by a significant residual porosity within the struts, whereas in wet‐milled foams struts and pore windows were highly compact, the key to provide sufficient mechanical strength to such highly porous open‐cell foams, thus suggesting a possible use as implantable scaffolds.
Numerical analysis of the vibroacoustic properties of plates with embedded grids of acoustic black holes (2015)

The concept of an Acoustic Black Hole (ABH) has been developed and exploited as an approach for passively attenuating structural vibration. The basic principle of the ABH relies on proper tailoring of the structure geometrical properties in order to produce a gradual reduction of the flexural wave speed, theoretically approaching zero. For practical systems the idealized "zero" wave speed condition cannot be achieved so the structural areas of low wave speed are treated with surface damping layers to allow the ABH to approach the idealized dissipation level. In this work, an investigation was conducted to assess the effects that distributions of ABHs embedded in plate-like structures have on both vibration and structure radiated sound, focusing on characterizing and improving low frequency performance. Finite Element and Boundary Element models were used to assess the vibration response and radiated sound power performance of several plate configurations, comparing baseline uniform plates with embedded periodic ABH designs. The computed modal loss factors showed the importance of the ABH unit cell low order modes in the overall vibration reduction effectiveness of the embedded ABH plates at low frequencies where the free plate bending wavelengths are longer than the scale of the ABH.
Biosensors: a tutorial review (2006)

This paper discusses various biosensors in detail, where the biosensor consists of bioelement and a sensor element. The bioelement may be an enzyme, antibody, living cells etc., and the sensing element may be electric current, electric potential, and so on. This survey initially introduces the basic concept of the biosensors. High-level overviews of different types of biosensors are given and the working principles, constructions, advantages and applications of many biosensors are also presented. In addition to these MEMS have given rise to a whole new class of biosensors which involve the transduction of mechanical energy and are based on mechanical phenomena.
A compressometer for obtaining stress-strain curves of rock specimens up to fracture (1957)

A compressometer is described by which the axial compressive strains occurring in a cylindrical rock specimen subjected to a linear axial compressive load in a compression test, can be read, or recorded continuously up to the point of fracture of the specimen. The measuring elements are U-pieces to which wire resistance strain gauges are cemented. The U-pieces are built into the compressometer in such a way that when the specimen, to which the compressometer is attached, fractures, they fall unharmed from the compressometer. The instrument has been used to obtain the stress-strain curves of many rock specimens without its accuracy being impaired or suffering physical damage.
Field based reliability and validity of the bioharness™ multivariable monitoring device. (2012)

The Bioharness™ device is designed for monitoring physiological variables in free-living situations but has only been proven to be reliable and valid in a laboratory environment. Therefore, this study aimed to determine the reliability and validity of the Bioharness™ using a field based protocol. Twenty healthy males participated. Heart rate (HR), breathing frequency (BF) and accelerometry (ACC) were assessed by simultaneous measurement of two Bioharness™ devices and a test-retest of a discontinuous incremental walk-jog-run protocol (4 - 11 km·h(-1)) completed in a sports hall. Adopted precision of measurement devices were; HR: Polar T31 (Polar Electro), BF: Spirometer (Cortex Metalyser), ACC: Oxygen expenditure (Cortex Metalyser). For all data, precision of measurement reported good relationships (r = 0.61 to 0.67, p < 0.01) and large Limits of Agreement for HR (>79.2 b·min(-1)) and BF (>54.7 br·min(-1)). ACC presented excellent precision (r = 0.94, p < 0.01). Results for HR (r= ~0.91, p < 0.01: CV <7.6) and ACC (r > 0.97, p < 0.01; CV <14.7) suggested these variables are reliable. BF presented more variable data (r = 0.46-0.61, p < 0.01; CV < 23.7). As velocity of movement increased (>8 km·h(-1)) data became more erroneous. A data cleaning protocol removed gross errors in the data analysis and subsequent reliability and validity statistics improved across all variables. In conclusion, the Bioharness™ HR and ACC variables have demonstrated reliability and validity in a field setting, though data collected at higher velocities should be treated with caution. Measuring human physiological responses in a field based environment allows for more ecologically valid data to be collected and devices such as the Bioharness™ could be used by exercise professionals to begin to further investigate this area.
Intraoral Topical Nonsteroidal Antiinflammatory Drug Application for Headache Prevention (2002)

Recent evidence suggests an association between migraine and tension-type headache and local inflammation occurring in a maxillary nerve segment. This study was designed to evaluate the efficacy of topical ketoprofen for the prevention of migraine, tension-type, and posttraumatic headache. Patients with a headache frequency of at least once a week recorded the frequency, severity, duration, and type of headache for 60 days. After 30 days, patients applied the medication daily for the next 30 days to the periapical area of the maxillary molars on the symptomatic side(s). Headache medications and analgesics were permitted, as needed. Headache burden was defined as the average intensity of each headache (0-10 scale) multiplied by its duration, in hours. The average monthly headache burden score for the 20 patients enrolled in this study decreased from 454.8 (30-day baseline) to 86.5 P < 0.001 during the 30-day treatment phase. Analgesic and headache medication intake were significantly reduced from baseline during the treatment phase, and side effects were minimal.
Constitutive Analyses of Nontraditional Stabilization Additives (2004)

Abstract : Personnel of the U.S. Army Engineer Research and Development Center (ERDC), Vicksburg, MS, conducted a series of laboratory experiments designed to characterize the constitutive properties of selected soil minerals and nontraditional stabilization additives. The results of these experiments were analyzed and included in this report to document the baseline characteristics prior to mixing the stabilizers and individual soil minerals. Analyses of the potential of individual stabilization products to reinforce specific soil types were conducted and reported. Additionally, an experimental modeling approach for describing the reinforcement mechanisms of individual stabilization agents was developed.
Signal Design and Error Rate of an Impulse Noise Channel (1971)

An optimal signal design of the classical smeardesmear technique for combating impulse noise is demonstrated. The signal design makes use of calculus of variations to derive an integral equation to which several solutions are given, along with a technique for generating additional solutions. A computer simulation and an evaluation of Rice's triple integral pdf for impulse noise are used to analyze the error probability of a smear-desmear data channel and a standard data channel. This is the first known publication of a general evaluation of Rice's integral for the intermediate repetition rate case. The error rates show that the smeardesmear channel is superior only for the lower repetition rate and/or lower level impulse noise cases. An analysis is then made of a clipper before the receiving filter. It is shown that this improves the system error rate to a degree, depending on the clipping level and the preclipper bandwidth-with the wider bandwidth giving greater improvement. The smear-desmear channel experienced a greater improvement than the conventional channel, so that the smear-desmear channel can be considered superior except for very high noise levels or repetition rates; practical considerations in the preclipper bandwidth and clipping level are the limiting factors.
Accelerated atherosclerosis in inflammatory rheumatic diseases (2004)

Over recent years it has become clear that patients with inflammatory rheumatic diseases are at increased risk of developing atherosclerosis. The exact causes for this are probably related in part to a general adverse effect of inflammation on atherogenesis, and in part to immune mechanisms specific to individual rheumatic diseases. This review discusses proposed mechanisms of accelerated atherosclerosis, including abnormal lipid and lipoprotein profiles, oxidative stress, enhanced apoptosis, thrombophilia, immune complexes, and increased mononuclear cell infiltration of atherosclerotic lesions, and local generation of cytokines.
The relationship between cognitive inhibition and psychotic symptoms. (2000)

Cognitive models of schizophrenia have highlighted deficits of inhibitory attentional processes as central to the disorder. This has been investigated using "negative priming" (S. P. Tipper, 1985), with schizophrenia patients showing a reduction of negative priming in a number of studies. This study attempted to replicate these findings, but studied psychotic symptoms rather than the broad diagnostic category of schizophrenia. Psychotic individuals exhibiting positive symptoms were compared with asymptomatic psychiatric patients and with a normal control group. As predicted, the symptomatic group failed to show the usual negative priming effect, which was present in the asymptomatic and normal groups. A modest but significant correlation was found between negative priming and delusions. Neither diagnosis, nor affective or negative symptoms, nor chronicity, nor medication, was related to negative priming. These data replicate previous findings that positive symptoms are related to a reduction in cognitive inhibition, although considerable variability was observed among the psychotic patients.
Total Synthesis of Sanglifehrin A (1999)

The immunosuppressive agent sanglifehrin A has been prepared for the first time by total synthesis. The construction of the macrocyclic unit of the target molecule was achieved through a selective intramolecular Stille coupling, and the spirolactam unit by Paterson–aldol reactions. The final steps involve an intermolecular Stille coupling and the opening of the internal acetal unit. This convergent synthesis opens the way for the synthesis of libraries of novel sanglifehrin analogues for biological screening.
Effects of diabetes mellitus on gastrointestinal motor function (1997)

Disordered gastrointestinal motility occurs frequently, and represents a generally underestimated cause of morbidity in patients with diabetes mellitus. The aetiology of gastrointestinal symptoms, which are presumed to arise primarily as a result of abnormal motor function, is poorly understood. It has been established, however, that changes in both gastrointestinal motor function and the perception of sensations arising from the gastrointestinal tract, may result from acute changes in the blood glucose concentration. The rate of gastric emptying is an important determinant of postprandial blood glucose homeostasis in normal subjects and in patients with Type 1 or Type 2 diabetes mellitus. It appears probable that modulation of gastric emptying will prove to be a therapeutically useful approach to the optimisation of glycaemic control in patients with diabetes mellitus. © 1997 John Wiley & Sons, Ltd.
SOLVENT EXTRACTION OF β-GALACTOSIDASE FROM KLUYVEROMYCES LACTIS YIELDS A STABLE AND HIGHLY ACTIVE ENZYME PREPARATION (2011)

ABSTRACT The yeast Kluyveromyces lactis was cultured in cheese whey and β-galactosidase was extracted from cells by an organic solvent procedure. Under optimum conditions (pH 8.5, 25C), approximately 90% of the intracellular β-galactosidase activity was released into 0.1 M potassium phosphate solution with 2% chloroform after 9 h. The cell-free extract containing β-galactosidase activity was concentrated and the enzyme partially characterized. This enzyme has exhibited an optimum activity at a pH range of 6.2–6.6 and temperature of 40–45C on O-nitrophenyl-β-D-galctopyranoside. The maximum enzyme activity in milk was found at 45C and the concentrated enzymatic extract was found to have 19 U/mg protein. A feasible preparation for commercial application containing 20% glycerol maintained 89% of activity after 2 months at 4C, demonstrating stability. This preparation analyzed on 5% nondenaturing polyacrylamide gel electrophoresis exhibited two bands suggesting two aggregation forms with β-galactosidase activity. PRACTICAL APPLICATIONS Kluyveromyces lactis yeast cells are a safe source of β−galactosidase for food and pharmaceutical industries. Their application to prior hydrolysis of lactose in milk products has become commonplace in alleviating the symptoms of lactose intolerance. It is also of great interest to prevent lactose crystallization in concentrated or frozen dairy products such as condensedmilk, ice cream and “dulce de leche,” thereby increasing consumers' acceptability. In addition, treatment of cheese whey with β-galactosidase increases its fermentability to convert cheese whey lactose into ethanol helping to reduce the pollution caused by large volumes of this by-product released in the environment. Solvent extraction of β-galactosidase from K. lactis is a low-cost process and yields a stable and highly active enzyme preparation.