gebhart/patrepeval huggingface dataset:
Benefits of whole ginger extract in prostate cancer (2011)

It is appreciated far and wide that increased and regular consumption of fruits and vegetables is linked with noteworthy anticancer benefits. Extensively consumed as a spice in foods and beverages worldwide, ginger (Zingiber officinale Roscoe) is an excellent source of several bioactive phenolics, including non-volatile pungent compounds such as gingerols, paradols, shogaols and gingerones. Ginger has been known to display anti-inflammatory, antioxidant and antiproliferative activities, indicating its promising role as a chemopreventive agent. Here, we show that whole ginger extract (GE) exerts significant growth-inhibitory and death-inductory effects in a spectrum of prostate cancer cells. Comprehensive studies have confirmed that GE perturbed cell-cycle progression, impaired reproductive capacity, modulated cell-cycle and apoptosis regulatory molecules and induced a caspase-driven, mitochondrially mediated apoptosis in human prostate cancer cells. Remarkably, daily oral feeding of 100 mg/kg body weight of GE inhibited growth and progression of PC-3 xenografts by approximately 56 % in nude mice, as shown by measurements of tumour volume. Tumour tissue from GE-treated mice showed reduced proliferation index and widespread apoptosis compared with controls, as determined by immunoblotting and immunohistochemical methods. Most importantly, GE did not exert any detectable toxicity in normal, rapidly dividing tissues such as gut and bone marrow. To the best of our knowledge, this is the first report to demonstrate the in vitro and in vivo anticancer activity of whole GE for the management of prostate cancer.
Mechanism of oxygen poisoning of ammonia synthesis catalyst (2009)

The effect of oxygen adsorbed on the surface of a commercial catalyst from a mixture of hydrogen with water vapor on the steady-state and nonsteady-state ammonia synthesis kinetics is studied under gradientless conditions at the pressures of the stoichiometric nitrogen-hydrogen mixture below the atmospheric pressure and at the temperatures of 285 and 240°C. The results obtained are discussed on the basis of the concepts of the ammonia synthesis theory of Temkin. The poisoning effect of oxygen on the reaction rate is explained by an increase in the activation energy of the rate constant k + in the Temkin-Pyzhev equation, i.e., an increase in the activation energy of the rate constant of nitrogen adsorption at the fixed nitrogen adsorption heat. This conclusion agrees with the concepts of Ertl et al., according to which the activation energy of nitrogen adsorption on iron changes in symbasis with the variation of the electronic work function. Oxygen adsorption on the catalyst surface increases the electronic work function. Thus, the mechanism of the catalyst poisoning by oxygen (at its low surface coverage) consists in an increase in the electronic work function. Assumptions are stated as to the role of chemical promoters of iron catalysts.
Synthesis of Possible Cancer Chemotherapeutic Compounds Based on Enzyme Approach. IV. Aziridine Derivatives<sup>1</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Possible Cancer Chemotherapeutic Compounds Based on Enzyme Approach. IV. Aziridine Derivatives1K. C. Tsou, K. Hoegerle, and Helen C. F. SuCite this: J. Med. Chem. 1963, 6, 4, 435–439Publication Date (Print):July 1, 1963Publication History Published online1 May 2002Published inissue 1 July 1963https://pubs.acs.org/doi/10.1021/jm00340a021https://doi.org/10.1021/jm00340a021research-articleACS PublicationsRequest reuse permissionsArticle Views144Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Building a modular service oriented workflow engine (2009)

Current workflow engines, often based on WS-BPEL, are monolithic programs to orchestrate a business process or take part in choreography between partners. They cover aspects like the execution of the workflow description derived from the business process, the communication with external services, and the handling of errors. Both, the communication with services as well as basic error handling are covered by static and internal APIs [1], and thus provide only simple strictly internal means of interaction with running workflows. Introducing new repair algorithms or self-healing behavior require detailed monitoring and modification of all aspects of a workflow execution thus requiring a modularization of the workflow engine itself. In this paper we will present a modular and service oriented workflow engine. Modularity and service-orientedness are realized by integrating a workflow execution engine with means of logging, repair and possibility to invoke external services through simple web-based APIs.
Clustering of multiallele DNA markers near the Huntington's disease gene. (1989)

Five highly informative multiallele restriction fragment length polymorphisms (RFLPs) of value for preclinical diagnosis of Huntington's disease (HD) have been genetically characterized. One RFLP was uncovered by expansion of the D4S43 locus while three others are at D4S111 and D4S115, loci defined by NotI-linking clones. The final marker, D4S125, represents a recently discovered VNTR locus. All four loci map closer to the HD gene and to the telomere than D4S10, the original linked marker for HD. In combination with two multiallele RFLPs previously identified for D4S43 and another linked locus, D4S95, these five new multiallele markers will dramatically improve the speed and accuracy of predictive testing in HD, and increase its applicability by maximizing the chances of an informative test for anyone with appropriate family structure.
Oral IGF-I enhances nutrient and electrolyte absorption in neonatal piglet intestine (1999)

The effect of orally administered insulin-like growth factor-I (IGF-I) on small intestinal structure and function was studied in 5-day-old colostrum-deprived piglets. Human recombinant IGF-I (3.5 mg. kg(-1). day(-1)) or control vehicle was given orogastrically for 4 days. Body weights, jejunal and ileal mucosa wet and dry weights, and serum IGF-I levels were similar in the two groups. Small intestinal villus height and crypt depth and jejunal enterocyte microvillar dimensions were also similar between groups. Oral IGF-I produced higher rates of jejunal ion transport because of increased basal Na+ absorption. Short-circuit current responses to mucosal addition of D-glucose and L-alanine and net transepithelial absorption of 3-O-methylglucose were increased by IGF-I. Carrier-mediated uptake of D-glucose per milligram in everted jejunal sleeves was greater in IGF-I-treated piglets because of a significantly greater maximal rate of uptake. We conclude that rates of net Na+ and Na+-dependent nutrient absorption are enhanced in piglets treated with oral IGF-I, and this effect is independent of changes in mucosal mass or surface area.
Cost analysis of distribution channels : an empirical determination of the optimal channel strategy (1985)

The area of channel selection and evaluation is perceived as being an increasingly important component of any firm's marketing strategy. Despite this, empirical research has been limited primarily to surveys of existing practices. Although models have been developed, they have remained, for the most part, in the theoretical realm. The primary reason for this appears to be the difficulty in obtaining the requisite accounting data. The purpose of this study was two-fold: (1) to identify the accounting data necessary to enable a firm to select the most effective channels of distribution; and (2) to provide empirical evidence that changes in the distribution strategy by a firm represent movements in the direction of the most effective channel strategy. A profit maximization model developed by Zoltners, Rangan and Becker of Northwestern University was used to predict the optimal channel strategy. The dealer network of a regional paint manufacturer was selected for analysis. Over a five-year period, sixty-two dealers in fourteen geographic areas were considered as potential market intermediaries. Contribution margin and direct costs were calculated. Advertising costs were reviewed. Actual results were compared to the results predicted by the model. Changes in the dealer network over the five-year period were identified and analyzed with respect to whether or not such changes reflected increased profits. In eight of the fourteen geographic areas, the company was already utilizing the optimal dealer. In the remaining six areas, the company made four changes. All changes resulted in increased profits for the company. Based on this study, it was concluded that the company was moving in the direction of profit maximization. This movement, however, seemed to be intuitive, rather than based on any formal strategy or evaluation. The accounting data necessary for effective evaluation of channel strategy was not readily available to management. Neither marketing management nor the accountant appeared the be cognizant of the importance of marketing costs in channel selection.
Loan pricing model for SMEs based on credit risk adjustment (2011)

Through comparatively analyzing the ways adopted by western commercial banks to make a loan price, this article establish a loan pricing model that suitable for SMEs from the standpoint of city small and medium-sized banks, in order to help banks to make better financial services for small and medium-sized enterprises (SMEs). At the same time, the article also adopt one regional commercial bank's data to made empirical test, to explain it is a viable method to use that loan pricing models to solve the problem of the interest changes from the control price into the market price.
A Novel Design of Reconfigurable Slot Antenna With Switchable Band Notch and Multiresonance Functions for UWB Applications (2012)

A novel printed reconfigurable square slot antenna with switchable band-notched and multiresonance performances is designed and manufactured. In the proposed structure, in order to generate single band-notched characteristics, a Π-shaped slot is etched on the radiating stub. Furthermore, to achieve a reconfigurable function, a p-i-n diode is utilized across the slot. When this p-i-n diode is biased forwardly, the Π -shaped slot transforms to a pair of C-shaped slots, and also by changing to this new structure, an additional resonance is excited. Additionally, by cutting two modified L-shaped slits with variable dimensions on the microstrip feed line, new additional resonance is excited, and hence wider impedance bandwidth can be produced, especially at the higher band. The designed antenna has a small size of 20 × 20 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> while showing the radiation performance in the frequency band of 3.04 to over 11.17 GHz with a switchable band-rejection performance in the frequency band of 5.03-5.94 GHz. Simulated and experimental results obtained for this antenna show that it exhibits good radiation behavior within the ultrawideband (UWB) frequency range and also it has a reconfigurable frequency band-notched function in the range of 5-6 GHz that can eliminate the interference between UWB frequency band and other existing wireless communication systems.
Cracking passwords (2010)

Passwords are all around us. We use them to authenticate ourselves to mobile phone and broadband service providers. We have to keep track of multiple passwords to access websites and online services. We may use them to secure our computers or individual files. The supposed strength of this security is the assumption that a password is something only we know. But are passwords adequate for today's security needs? How easy is it to crack them? And what are the technologies that threaten the password's usefulness? In this first instalment of a two-part feature, security journalist Steve Gold explores the current state of password- and password-cracking technology. Passwords are all around us. We use them to authenticate ourselves to mobile phone and broadband service providers. We have to keep track of multiple passwords to access websites and online services. We may use them to secure our computers or individual files. The supposed strength of this security is the assumption that a password is something only we know.
Direct Blood PCR in Combination with Nucleic Acid Lateral Flow Immunoassay for Detection of Plasmodium Species in Settings Where Malaria Is Endemic (2012)

Declining malaria transmission and known difficulties with current diagnostic tools for malaria, such as microscopy and rapid diagnostic tests (RDTs) in particular at low parasite densities, still warrant the search for sensitive diagnostic tests. Molecular tests need substantial simplification before implementation in clinical settings in countries where malaria is endemic. Direct blood PCR (db-PCR), circumventing DNA extraction, to detect Plasmodium was developed and adapted to be visualized by nucleic acid lateral flow immunoassay (NALFIA). The assay was evaluated in the laboratory against samples from confirmed Sudanese patients (n = 51), returning travelers (n = 214), samples from the Dutch Blood Bank (n = 100), and in the field in Burkina Faso (n = 283) and Thailand (n = 381) on suspected malaria cases and compared to RDT and microscopy. The sensitivity and specificity of db-PCR-NALFIA compared to the initial diagnosis in the laboratory were 94.4% (95% confidence interval [CI] = 0.909 to 0.969) and 97.4% (95% CI = 0.909 to 0.969), respectively. In Burkina Faso, the sensitivity was 94.8% (95% CI = 0.88.7 to 97.9%), and the specificity was 82.4% (95% CI = 75.4 to 87.7%) compared to microscopy and 93.3% (95% CI = 87.4 to 96.7%) and 91.4% (95% CI = 85.2 to 95.3%) compared to RDT. In Thailand, the sensitivity and specificity were 93.4% (CI = 86.4 to 97.1%) and 90.9 (95% CI = 86.7 to 93.9%), respectively, compared to microscopy and 95.6% (95% CI = 88.5 to 98.6%) and 87.1% (95% CI = 82.5 to 90.6) compared to RDT. db-PCR-NALFIA is highly sensitive and specific for easy and rapid detection of Plasmodium parasites and can be easily used in countries where malaria is endemic. The inability of the device to discriminate Plasmodium species requires further investigation.
Query Processing on Multi-Core Architectures (2009)

The upcoming generation of computer hardware poses several new challenges for database developers and engineers. Software in general and database management systems (DBMSs) in particular will no longer benefit from performance gains of future hardware due to increase clock speed, as it was the case for the last 35 years; instead, the number of cores per CPU will increase steadily. Today’s approach is to run each query on a single core or only a few different cores using parallel query execution. This approach suffers from several problems (e.g. contention problem) and therefore leads to poor speed up and scale up behavior. These observations open several important research questions on how to use the new multi-core CPU architecture for improving the overall performance of DBMSs. This paper outlines our approach for query processing on multi-core CPU architectures. We present an abstract architecture view for multi-core CPUs, meta operators to control and to interact with the hardware, and a new query operator model that makes use of the meta operators to control the parallel execution of a query over different cores. We illustrate how each of these parts fits in our framework for query processing on multi-core architectures.
Design of Wrist Gimbal: A forearm and wrist exoskeleton for stroke rehabilitation (2013)

In this paper, we present design, implementation and specifications of the Wrist Gimbal, a three degree-of-freedom (DOF) exoskeleton developed for forearm and wrist rehabilitation. Wrist Gimbal has three active DOF, corresponding to pronation/supination, flexion/extension and adduction/abduction joints. We mainly focused on a robust, safe and practical device design to facilitate clinical implementation, testing and acceptance. Robustness and mechanical rigidity was achieved by implementing two bearing supports for each of the pronation/supination and adduction/abduction axes. Rubber hard stops for each axis, an emergency stop button and software measures ensured safe operation. An arm rest with padding and straps, a handle with adjustable distal distance and height and a large inner volume contribute to ease of use, of patient attachment and to comfort. We present the specifications of Wrist Gimbal in comparison with similar devices in the literature and example data collected from a healthy subject.
Managing Uncertainties on Production Predictions Using Integrated Statistical Methods (1999)

Reservoir engineering requires to manage many sources of uncertainties that can be classified in two categories : (a) uncontrolled uncertainties on the physical reservoir description parameters and (b) controlled uncertainties on the reservoir development scheme parameters. In this context engineers must answer several problems : describe prior uncertainties, identify the ones that actually influence the oil production process, make safe production forecasts and optimize the reservoir production scheme.In this paper, several statistical methods dealing with these problems are presented. They are (a) Experimental Design, (b) Response Surface Methodology and (c) Monte-Carlo methods. Integrating these techniques enables to build a simplified model of a process and to estimate the uncertainties on the response predictions. The entire procedure was applied to a field case showing both types of controlled and uncontrolled uncertainties. The result is a new frame allowing engineers to quantify uncertainties on the reservoir production forecasts conditionally to uncertainties on the reservoir modeling parameters. The procedure has lower computational costs than the traditional one but is quite complex and needs adapted software to be used by reservoir engineers.
Intragastric pressure as a determinant of food intake (2012)

These findings indicate that IGP per se does not affect satiation but that a gradual IGP increase during food intake is associated with decreased food intake, indicating that gastric accommodation is an important determinant of food intake.
Adipose-Derived Stem Cells for Future Regenerative System Medicine (2012)

BACKGROUND: The potential use of stem cell-based therapies for repair and regeneration of various tissues and organs offers a paradigm shift that may provide alternative therapeutic solutions for a number of disease. Despite the advances, the availability of stem cells remaining a challenge for both scientist and clinicians in pursuing regenerative medicine. CONTENT: Subcutaneous human adipose tissue is an abundant and accessible cell source for applications in tissue engineering and regenerative medicine. Routinely, the adipose issue is digested with collagenase or related lytic enzymes to release a heterogeneous population for stromal vascular fraction (SVF) cells. The SVF cells can be used directly or can be cultured in plastic ware for selection and expansion of an adherent population known as adipose-derived stromal/stem cells (ASCs). Their potential in the ability to differentiate into adipogenic, osteogenic, chondrogenic and other mesenchymal lineages, as well in their other clinically useful properties, includes stimulation of angiogenesis and suppression of inflammation.SUMMARY: Adipose tissue is now recognized as an accessible, abundant and reliable site for the isolation of adult stem cels suitable for the application of tissue engineering and regenerative medicine applications. The past decade has witnessed an explosion of preclinical data relating to the isolation, characterization, cryopreservation, differentiation, and transplantation of freshly isolated stromal vascular fraction cells and adherent, culture-expanded, adipose-derived stromal/stem cells in vitro and in animal models.KEYWORDS: adipose tissue, adult stem cells, regenerative medicine, mesenchymal stem cells
Mo and Cu Modified FeK/SiO_2 Catalysts for Fischer-Tropsch Synthesis (2010)

The effects of Mo and Cu promoters on the properties of FeK/SiO2 catalysts and their Fischer-Tropsch synthesis(FTS) performance were studied.The catalysts were characterized by N2 adsorption,H2 temperature-programmed reduction,X-ray diffraction,M?ssbauer effect spectroscopy and X-ray photoelectron spectroscopy.The characterization results indicate that Mo addition inhibits the reduction and carburization of the catalysts,which is opposite to Cu promoter.When Mo and Cu are co-added,similar reduction and carburization behavior is observed as that of Cu promoter alone.FTS performance was tested at 280 oC,1.5 MPa,2 000 h?1,and syngas H2/CO = 2.0 in a fixed-bed reactor.The reaction results show that Mo addition decreases the FTS activity and improves the stability of heavy hydrocarbon(C5+) selectivity over the catalysts;Cu addition increases the activity but has no contribution to the stability of C5+ selectivity.For the co-promoted catalyst,stable selectivity to C5+ is obtained without sacrificing activity.
Typography for journals (1994)

ABSTRACT Considers the principles of typography in relation to readers and readability, type of text, editorial methods, and the effects of new electronic publishing options.
An Efficient, Bolus-Stage Based Method for Motion Correction in Perfusion Weighted MRI (2014)

This paper addresses the data corruption that occurs due to patient motion during a scan which is particularly a problem in perfusion weighted MRI due to long scan times. Motion correction is typically the ratelimiting step in processing as each volume has to be registered to a reference volume. This is compounded by the dynamically varying contrast in the volume series due to passage of an injected contrast agent. We propose an efficient two stage motion correction method, consisting of motion detection and a 2-pass registration method for aligning the motion-corrupted volumes. A 2D block-wise phase correlation in central slices is used for the first stage. Alignment employs a strategy which is sensitive to the status of the bolus in the volume and is based on gamma-variate function fitting for intensity correction to handle dynamic contrast in DSC-MRI. Evaluation of the approach shows that it is fast and accurate. 1.