gebhart/patrepeval huggingface dataset:
7-Substituted actinomycin D analogs. Chemical and growth-inhibitory studies (1975)

The synthesis and biological activity of three 7-substituted actinomycin D derivatives are reported. Three such derivatives, 7-nitro-, 7-amino-, and 7-hydroxyactinomycin D, were synthesized via new methods which were first tested successfully with a chromophore model system. Of these, 7-nitro- and 7-aminoactinomycin D were assayed for growth inhibitory activity against mammalian cells (CCRF-CEM human lymphoblastic leukemia) in vitro and against the Ridgway osteogenic sarcoma and the L1210, P1534, and P388 murine leukemias in vivo. In these systems, the inhibitory activity of the 7-substituted analogs was comparable to actinomycin D. In two bacterial systems ( (L. casei and L. arabinosus) in vitro, on the other hand, these compounds showed inhibitory profiles which are distinctly different from actinomycin D. These studies demonstrate that substitution at the 7 position, which does not interfere with DNA binding, is capable of yielding experimental antitumor agents with significant activity against a variety of tumors.
Intelligence: Knowns and unknowns. (1996)

Ulric Neisser (Chair) Gwyneth Boodoo Thomas J. Bouchard, Jr. A. Wade Boykin Nathan Brody Stephen J. Ceci Diane E Halpern John C. Loehlin Robert Perloff Robert J. Sternberg Susana Urbina Emory University Educational Testing Service, Princeton, New Jersey University of Minnesota, Minneapolis Howard University Wesleyan University Cornell University California State University, San Bernardino University of Texas, Austin University of Pittsburgh Yale University University of North Florida
Dual damascene photo process using negative-tone resist (2000)

To further improve device performance, copper has been introduced to replace aluminum as the interconnect material due to its lower resistivity. Copper/low-k dual damascene process requires significant changes in process design and implementation from the traditional aluminum interconnect architecture. There are several implementation schemes for dual damascene architecture, including via first, trench first and buried hard mask. Among these schemes, via first process provides the largest process tolerance for stepper/scanner overlay control in addition to the guaranteed full size vias. However, positive tone resist encounters some difficulties in dual damascene photo process for via first approach, because the resist filled in the via can not be exposed and removed properly, resulting in considerable resist residual in the via after development. In contrast, negative tone resist shows great advantage in this process and demonstrates its capability in producing desired patterns without resist residuals in the via. In this paper, the design of a dual damascene photo process using Shipley UVN30 negative tone resist is evaluated, and experimental results regarding to its process performance are presented.
Highly Stereoselective Proton/Hydride Exchange: Assistance of Hydrogen Bonding for the Heterolytic Splitting of H<sub>2</sub> (2009)

The dihydrido amine complex [Ru(H)(2)PMe(3){HN(CH(2)CH(2)P(i)Pr(2))(2)}] and H(2)O exhibit highly unusual, stereoselective H(+)/H(-) exchange, as derived using (1)H 2D EXSY NMR spectroscopy. While H(RuA) rapidly exchanges with H(2)O [k = 337(20) L mol(-1) s(-1)], no direct H(RuB)/H(2)O proton exchange was detected. Methylation of the pincer amine nitrogen results in unselective slow exchange of both hydrides with H(2)O. These results emphasize the important role of hydrogen bonding of N with Brønsted acids (e.g., water) for heteroloytic H(2) activation with Ru-amide hydrogenation catalysts, which was confirmed computationally.
Graph OLAP: a multi-dimensional framework for graph data analysis (2009)

Databases and data warehouse systems have been evolving from handling normalized spreadsheets stored in relational databases, to managing and analyzing diverse application-oriented data with complex interconnecting structures. Responding to this emerging trend, graphs have been growing rapidly and showing their critical importance in many applications, such as the analysis of XML, social networks, Web, biological data, multimedia data and spatiotemporal data. Can we extend useful functions of databases and data warehouse systems to handle graph structured data? In particular, OLAP (On-Line Analytical Processing) has been a popular tool for fast and user-friendly multi-dimensional analysis of data warehouses. Can we OLAP graphs? Unfortunately, to our best knowledge, there are no OLAP tools available that can interactively view and analyze graph data from different perspectives and with multiple granularities. In this paper, we argue that it is critically important to OLAP graph structured data and propose a novel Graph OLAP framework. According to this framework, given a graph dataset with its nodes and edges associated with respective attributes, a multi-dimensional model can be built to enable efficient on-line analytical processing so that any portions of the graphs can be generalized/specialized dynamically, offering multiple, versatile views of the data. The contributions of this work are three-fold. First, starting from basic definitions, i.e., what are dimensions and measures in the Graph OLAP scenario, we develop a conceptual framework for data cubes on graphs. We also look into different semantics of OLAP operations, and classify the framework into two major subcases: informational OLAP and topological OLAP. Second, we show how a graph cube can be materialized by calculating a special kind of measure called aggregated graph and how to implement it efficiently. This includes both full materialization and partial materialization where constraints are enforced to obtain an iceberg cube. As we can see, due to the increased structural complexity of data, aggregated graphs that depend on the underlying “network” properties of the graph dataset are much harder to compute than their traditional OLAP counterparts. Third, to provide more flexible, interesting and informative OLAP of graphs, we further propose a discovery-driven multi-dimensional analysis model to ensure that OLAP is performed in an intelligent manner, guided by expert rules and knowledge discovery processes. We outline such a framework and discuss some challenging research issues for discovery-driven Graph OLAP.
Immunohistochemistry of normal human skin. (1998)

The skin is the largest organ of the body and consists of various cell types (epithelial, mesenchymal, vascular, neural, muscular). The cellular and extracellular components of the skin express an ever-growing number of antigens that can be recognised by specific monoclonal or polyclonal antibodies. Whereas several antigens are widely distributed, some differentiation antigens are sufficiently specific and sensitive to particular components [...]
Moisture Removal Substantially Improves the Efficiency of in Situ Biodiesel Production from Soybeans (2006)

Abstract In an effort to reduce the production cost of biodiesel, we previously described an approach termed “in situ transesterification” wherein the transesterification of a vegetable oil occurred directly in its raw agricultural material. In that method, substantial quantities of reagents were required to achieve high‐efficiency transesterification. Here we report that by drying the substrate a marked reduction in the reagent requirements was achieved. Reaction conditions for maximum fatty acid methyl ester (FAME) production were identified using statistical experimental design methods. In 16‐h reactions with 5 g of flakes (2.6% moisture) and 18 mL of 0.10 N NaOH in methanol, 97% theoretical maximum transesterification was achieved. For dry flakes, optimal transesterification was achieved in 10 h in reactions containing 5 g of flakes and 12 mL of 0.10 N NaOH in methanol. This represented a 60% reduction in methanol and a 56% reduction in NaOH use compared with the transesterification of full‐moisture flakes. Under these conditions the degree of transesterification was 100% of the theoretical maximum. The transesterification of 20 kg of flakes with a moisture content of 0.8% was conducted under optimal reaction conditions. Both triacylglycerols (TAG) and phosphoacylglycerols (PL) were transesterified to high degrees, with an overall efficiency of 97.3% of the maximum theoretical efficiency. PL were not detected in the flakes following transesterification, and the amount of remaining unreacted TAG was only 1.0% of that input. Following washes with water, 0.5 M NaCl, and dilute NaOH, the recovered FAME met the ASTM specifications for biodiesel. The tocopherol levels of the FAME exceeded by 76% those of a representative commercial biodiesel. Soy flakes retained 97% of their protein following in situ transesterification.
Regulation of RANTES and ICAM-1 expression in murine mesangial cells. (1997)

Chemokines and adhesion molecules play a pivotal role in leukocyte infiltration during tissue injury. RANTES (regulated upon activation, normal T cell expressed and secreted) is a monocyte chemoattractant that induces the expression of CD11/CD18 integrins on leukocytes for which intercellular adhesion molecule-1 (ICAM-1) is the ligand. Both RANTES and ICAM-1 can be expressed by mesangial cells (MC) in culture and in glomeruli during immune injury. In this study, the role of reactive oxygen species (ROS) in the activation of RANTES and ICAM-1 in murine MC was examined. Tumor necrosis factor alpha (TNF-alpha) and aggregated immunoglobulin (aggr. Ig) G, which enhance ROS formation in MC, increased mRNA transcripts of both RANTES and ICAM-1. Thiol-containing free-radical scavengers N-acetyl cysteine, dimethyl- and tetramethylthiourea, or pyrrolidinedithiocarbamate abrogated the increase in mRNA for RANTES and ICAM-1 in response to TNF-alpha or IgG. Hydroxy-methoxy acetophenone, an inhibitor of NADPH-dependent oxidase, also attenuated RANTES and ICAM-1 in response to TNF-alpha or IgG. ROS generated by addition of xanthine oxidase and hypoxanthine induced RANTES and ICAM-1 expression, whereas hydrogen peroxide caused no response. Because cAMP can interfere with gene activation in MC, the effects of 8-Br-cAMP, forskolin, and prostaglandin E2 on mRNA levels were examined for RANTES and ICAM-1. These agents attenuated the response to IgG aggregates and also to superoxide generation. Finally, the effect of glucocorticoids, which are frequently used in glomerular immune injury, was examined. Dexamethasone decreased mRNA for both RANTES and ICAM-1 after stimulation with aggr. IgG or TNF-alpha. Both forskolin and dexamethasone also reduced the amount of RANTES protein secreted by MC in response to aggr. IgG. Only dexamethasone decreased RANTES secretion in response to TNF-alpha stimulation. The inhibitory effects of cAMP and dexamethasone may explain the beneficial effects of cAMP mimetics, such as prostaglandin E2 and glucocorticoid administration on glomerular inflammatory processes.
Isolation and characterization of the transferrin receptor from human placenta. (1979)

The transferrin receptor has been isolated from human placenta using immunochromatography and affinity chromatography. The receptor is a glycoprotein and has a Mr = 90,000 on sodium dodecyl sulfate-gel electrophoresis in the presence of 2-mercaptoethanol. The isolated receptor is immunologically related to the transferrin receptor on the reticulocyte cell surface.
The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. (1999)

A previous report identified and classified a small family of gram-negative bacterial drug and heavy metal efflux permeases, now commonly referred to as the RND family (TC no. 2.6). We here show that this family is actually a ubiquitous superfamily with representation in all major kingdoms. We report phylogenetic analyses that define seven families within the RND superfamily as follows: (1) the heavy metal efflux (HME) family (gram negative bacteria), (2) the hydrophobe/amphiphile efflux-1 (HAE1) family (gram negative bacteria), (3) the nodulation factor exporter (NFE) family (gram negative bacteria), (4) the SecDF protein-secretion accessory protein (SecDF) family (gram negative and gram positive bacteria as well as archaea), (5) the hydrophobe/amphiphile efflux-2 (HAE2) family (gram positive bacteria), (6) the eukaryotic sterol homeostasis (ESH) family, and (7) the hydrophobe/amphiphile efflux-3 (HAE3) family (archaea and spirochetes). Functionally uncharacterized proteins were identified that are members of the RND superfamily but fall outside of these seven families. Some of the eukaryotic homologues function as enzymes and receptors instead of (or in addition to) transporters. The sizes and topological patterns exhibited by members of all seven families are shown to be strikingly similar, and statistical analyses establish common descent. Multiple alignments of proteins within each family allow derivation of family-specific signature sequences. Structural, functional, mechanistic and evolutionary implication of the reported results are discussed.
Building Information Modeling in Support of Sustainable Design and Construction (2012)

The use of building information modeling (BIM) has provided a means of increasing total project quality, providing accurate quantity take-offs, and improving scheduling, consequently diminishing total project contingencies and costs. Although BIM is a recent development, a lot of research has been conducted in order to further enhance the capabilities of BIM in design and construction. However, there has been very little research done so far on the effect that BIM has on sustainable construction practices. Hence, the goal of this research is to investigate the perceptions of the use of BIM for sustainable design and construction among designers and constructors. A survey was developed and administered through the Internet to determine the existing trends of BIM application in general as well as its use as a tool in sustainable design and construction. The survey results indicated that although the majority of the respondents believed that sustainable design and construction practices were of importance within their company, most still believed that sustainability was not a primary application of BIM and that project coordination and visualization were instead more important. Although BIM is perceived as a multidisciplinary tool, problems with interoperability continue to persist among the various BIM applications in the industry. In terms of project delivery methods, the majority of the survey respondents believed that design/build and integrated project delivery (IPD) are the optimal project delivery methods to integrate BIM as a sustainability tool. Although BIM is still a recent development, as more design and construction professionals understand the potential benefits offered through its use, BIM will become a vital tool for sustainable design and construction.
Region of Interest-Based Adaptive Multimedia Streaming Scheme (2008)

Adaptive multimedia streaming aims at adjusting the transmitted content based on the available bandwidth such as losses that often severely affect the end-user perceived quality are minimized and consequently the transmission quality increases. Current solutions affect equally the whole viewing area of the multimedia frames, despite research showing that there are regions on which the viewers are more interested in than on others. This paper presents a novel region of interest-based adaptive scheme (ROIAS) for multimedia streaming that when performing transmission-related quality adjustments, selectively affects the quality of those regions of the image the viewers are the least interested in. As the quality of the regions the viewers are the most interested in will not change (or will involve little change), the proposed scheme provides higher overall end-user perceived quality than any of the existing adaptive solutions.
Novel Duplicate Address Detection with Hash Function (2016)

Duplicate address detection (DAD) is an important component of the address resolution protocol (ARP) and the neighbor discovery protocol (NDP). DAD determines whether an IP address is in conflict with other nodes. In traditional DAD, the target address to be detected is broadcast through the network, which provides convenience for malicious nodes to attack. A malicious node can send a spoofing reply to prevent the address configuration of a normal node, and thus, a denial-of-service attack is launched. This study proposes a hash method to hide the target address in DAD, which prevents an attack node from launching destination attacks. If the address of a normal node is identical to the detection address, then its hash value should be the same as the "Hash_64" field in the neighboring solicitation message. Consequently, DAD can be successfully completed. This process is called DAD-h. Simulation results indicate that address configuration using DAD-h has a considerably higher success rate when under attack compared with traditional DAD. Comparative analysis shows that DAD-h does not require third-party devices and considerable computing resources; it also provides a lightweight security resolution.
Fe–N <sub>2</sub> /CO complexes that model a possible role for the interstitial C atom of FeMo-cofactor (FeMoco) (2013)

We report here a series of four- and five-coordinate Fe model complexes that feature an axial tri(silyl)methyl ligand positioned trans to a substrate-binding site. This arrangement is used to crudely model a single-belt Fe site of the FeMo-cofactor that might bind N2 at a position trans to the interstitial C atom. Reduction of a trigonal pyramidal Fe(I) complex leads to uptake of N2 and subsequent functionalization furnishes an open-shell Fe-diazenido complex. A related series of five-coordinate Fe-CO complexes stable across three redox states is also described. Spectroscopic, crystallographic, and Density Functional Theory (DFT) studies of these complexes suggest that a decrease in the covalency of the Fe-C(alkyl) interaction occurs upon reduction and substrate binding. This leads to unusually long Fe-C(alkyl) bond distances that reflect an ionic Fe-C bond. The data presented are contextualized in support of a hypothesis wherein modulation of a belt Fe-C interaction in the FeMo-cofactor facilitates substrate binding and reduction.
<i>Trichuris muris</i>: antigen recognition and transfer of immunity in mice by IgA monoclonal antibodies (1991)

Mesenteric node lymphocytes from mice that had been infected with the nematode Trichuris muris, and then boosted with adult worm excretory-secretory antigens were fused with myeloma cells to produce a panel of 9 monoclonal antibodies (MoAbs). Five of the MoAbs were of the IgA isotype. The antigen recognition profiles of these MoAbs were studied using SDS-PAGE and immunoblotting; three major profile patterns were identified. Five MoAbs recognized a major band in the MW range 43-48 kD; all recognized a range of antigens. Three MoAbs were used to localize antigens in the bodies of adult worms. Granules within the anterior stichocytes were recognized strongly, as was material within the eggs and pseudocoelom. Two MoAbs stained the cuticle. Although the phosphorylcholine (PC) determinant was widely distributed within worm tissues none of the MoAbs tested recognized PC. Passive transfer of immunity was achieved using two of the IgA monoclonals; no immunity was transferred by the IgM and IgG MoAbs used. The limited recognition profiles of these IgA MoAbs, and the ability to stain stichocyte granules, suggest that their protective activity results from an interaction with ES antigens.
SUBSET-SELECTION AND ENSEMBLE METHODS FOR WAVELET DE-NOISING (1999)

Many nonparametric regression procedures are based on selec- tion: they choose a subset of carriers from a large or even infinite set, and then determine the coefficients of the chosen carriers by least squares. Procedures which can be cast in this framework include Projection Pursuit, Turbo, Mars, and Match- ing Pursuit. Recently, considerable attention has been given to esti- mators which combine least squares estimates obtained from multiple subsets of carriers. In the parametric regression setting, such ensemble estimators have been shown to improve on the accuracy of subset selection procedures in some situations. In this paper we compare subset selection estimators and ensemble estimators in the context of wavelet de-noising. We present simulation results demonstrating that a certain class of ensemble wavelet estimators, based on the concept of cycle spinning, are significantly more accurate than subset selection methods. These advantages hold even when the subset selection procedures can rely on an oracle to select the optimal number of carriers. We compute ideal thresholds for translation invariant wavelet shrinkage and investigate other approaches to ensemble wavelet
Palladium-Catalyzed Carbonylation of Allyl Alcohols in the Presence of Phenols (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTPalladium-Catalyzed Carbonylation of Allyl Alcohols in the Presence of PhenolsTetsuya Satoh, Masahiro Ikeda, Yuichi Kushino, Masahiro Miura, and Masakatsu NomuraView Author Information Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565, Japan Cite this: J. Org. Chem. 1997, 62, 8, 2662–2664Publication Date (Web):April 18, 1997Publication History Received20 December 1996Published online18 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/jo962387nhttps://doi.org/10.1021/jo962387nbrief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1023Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Aromatic compounds,Carbonylation,Hydrocarbons,Organic compounds Get e-Alerts
Initiation and replication of vesicular stomatitis virus genome RNA in a cell-free system. (1983)

A system for studying the in vitro replication of the RNA genomes of both wild-type vesicular stomatitis virus (VSV) and its defective interfering particle MS-T has been developed. After lysolecithin treatment of cells infected with VSV or VSV plus MS-T, a cell-free cytoplasmic extract is prepared which will support VSV mRNA synthesis and the synthesis of the 42S wild-type or 19S MS-T genome RNAs. The genome-length RNAs synthesized in vitro are assembled into RNase-resistant nucleocapsids. The level of 42S RNA synthesis in vitro (6-13% of total RNA synthesis) reflects the level of replication in vivo. Although the extracts of VSV-infected cells can also support the synthesis of VSV proteins, RNA replication is not dependent on de novo protein synthesis but utilizes the preformed soluble proteins present in the infected cell at the time the extract is prepared. The initiation of genomic RNA during in vitro replication can be demonstrated because detergent-disrupted, purified MS-T particles will replicate their RNA when added to either a total cytoplasmic extract from VSV-infected cells or the soluble protein fraction derived from such an extract.