gebhart/patrepeval huggingface dataset:
A Meta-Analysis of Fluoxetine Outcome in the Treatment of Depression (1994)

A meta-analysis was conducted on all the double-blind, placebo-controlled efficacy trials of the antidepressant fluoxetine (Prozac). This drug has become the antidepressant most frequently prescribed by psychiatrists and has been hailed by the media as a "wonder drug." Results produced a relatively modest overall effect size that was no greater than effect sizes obtained by previous meta-analyses of tricyclic antidepressants. This study also examined the possibility that bias may have contaminated study outcome ratings. Because past studies suggest that the greater frequency of side effects in active drug groups unblinds study participants, we examined the relationship between study effect sizes and the percentage of patients reporting side effects. As predicted, both clinician and patient outcome ratings correlated significantly with the percentage of patients experiencing side effects. Questions are raised about the role of side effects in mediating drug outcome results.
HALOTHANE ANESTHESIA AS A METHOD OF IMMOBILIZING FREE-RANGING CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS) (1993)

Thirty free-ranging California sea lions, Zalophus californianus, including 20 adult females (approximate individual weight of 100 kg) and 10 newborn pups (average weight 7.9 kg) were anesthetized using halothane and oxygen on San Miguel Island, California. The halothane was delivered through a precision, out-of-circle vaporizer in a portable semiclosed circle system anes thesia machine. Sea lions were monitored for respiratory and heart rates, and time of capture, induction, and duration of anesthesia were recorded. Twenty-nine of the 30 sea lions recovered uneventfully; one adult female became apneic and died despite resuscitation efforts. Adults had significantly lower heart and respiratory rates than pups, although induction, anesthesia, and recovery times did not differ between age groups.
Protein Secondary Structure Prediction using Bayesian Inference method on Decision fusion algorithms (2007)

Prediction of protein secondary structure (alpha-helix, beta-sheet, coil) from primary sequence of amino acids is a very challenging task, and the problem has been approached from several angles. Previously research was performed in this field using several techniques such as neural networks, simulated annealing (SA) and genetic algorithms (GA) for improving the protein secondary structure prediction accuracy. Decision fusion methods such as the committee method and correlation methods were also used in combination with the profile-based neural networks and AI algorithms for achieving better prediction accuracy. In this research we investigate the Bayesian inference method for predicting the protein secondary structure. The Bayesian inference method proposed in this research uses the results from the committee and correlation methods to achieve better prediction accuracy. Simulations are performed using the RS126 data set. The results show that the protein secondary structure prediction accuracy can be improved by more than 2% using the Bayesian inference method.
Using UCODE_2005 and PHREEQC To Determine Thermodynamic Constants from Experimental Data (2007)

This article presents a method for estimating chemical thermodynamic constants from experimental data using the two computer programs UCODE_2005 and PHREEQC. As an example, the conditional stability constant for lead (Pb) complexation by a remediation agent (carboxymethyl-beta-cyclodextrin) is estimated, but the method can be applied to estimate other thermodynamic parameters such as sorption constants and degradation rate constants. Advantages of this technique include estimation of uncertainties associated with estimated parameters, evaluation of information content of observations, statistical evaluation of the appropriateness of the conceptual model, and statistical-based comparison of different models.
The expression of cytochrome P-450, epoxide hydrolase, and glutathione s-transferase in hepatocellular carcinoma (1993)

This study showed that the expression of xenobiotic-metabolizing enzymes in hepatocellular carcinoma is complex and the presence of different xenobiotic enzymes in hepatocellular carcinoma may contribute to the intrinsic drug resistance of these tumors.
Ternary silicate glasses (1987)

This is the third volume of a five-part comprehensive reference work on the properties of one-component, binary and ternary oxide glass-forming melts and glasses. Part A ``Silica Glass and Binary Silicate Glasses'' was published in 1983, and Part B ``Single-Component and Binary yon-Silicate Oxide Glasses'' in 1985. Part D will focus on ternary non-silicate oxide glasses, and the final volume will contain supplements providing new information published during the time of preparation of the first four parts. The present volume covers ternary silicate glasses. All ternary systems are united into large groups according to the valency of the elements forming the corresponding oxides. Within each of these groups the data are classified by properties. The sequence is as follows: glass formation, crystallization, density, thermal expansion and other thermal properties, optical properties, viscosity, elastic properties and internal friction, strength, surface tension, chemical durability, electrical properties, diffusion, permeation and solubility of gases, ion diffusion, volatilization and magnetic properties. Extensive references are included, as are author, subject and formula indexes.
Long-Term Bilayer Encapsulation Performance of Atomic Layer Deposited Al$_{\bf 2}$O$_{\bf 3}$ and Parylene C for Biomedical Implantable Devices (2013)

We present an encapsulation scheme that combines atomic layer deposited (ALD) Al₂O₃ and Parylene C for the encapsulation of implantable devices. The encapsulation performances of combining alumina and Parylene C was compared to individual layers of Parylene C or alumina and the bilayer coating had superior encapsulation properties. The alumina-Parylene coated interdigitated electrodes (IDEs) soaked in PBS for up to nine months at temperatures from 37 to 80 °C for accelerated lifetime testing. For 52-nm alumina and 6-μm Parylene C, leakage current was ∼20 pA at 5 VDC, and the impedance was about 3.5 MΩ at 1 kHz with a phase near -87° from electrochemical impedance spectroscopy for samples soaked at 67 °C for equivalent lifetime of 72 months at 37 °C. The change of impedance during the whole soaking period (up to 70 months of equivalent soaking time at 37 °C) over 1 to 10⁶ Hz was within 5%. The stability of impedance indicated almost no degradation of the encapsulation. Bias voltage effect was studied by continuously applying 5 VDC, and it reduced the lifetime of Parylene coating by ∼75% while it showed no measurable effect on the bilayer coating. Lifetime of encapsulation of IDEs with topography generated by attaching a coil and surface mount device (SMD) capacitor was about half of that of planer IDEs. The stable long-term insulation impedance, low leakage current, and better lifetime under bias voltage and topography made this double-layer encapsulation very promising for chronic implantable devices.
Knowledge and Identity: A Review (2009)

This paper reviews the literature in a number of areas that converge upon the theme of the role of knowledge within professional identity. Within knowledge transfer literature the individual perspective is underdeveloped, and this paper seeks to contribute by exploring the function of knowledge within an individual's professional identity, thus unfolding a theoretical connection between the literatures of knowledge and identity. Its central argument concurs with Szulanski's notion of ‘internal stickiness’ as a barrier to knowledge transfer but extends this hypothesis into the psychological ownership of knowledge and to the idea of ‘possessiveness’. The paper argues that the value of self‐categorized knowledge places the latter within the individual's cognitive structure of their identity. It offers up the idea of valued knowledge to the knowledge transfer domain and suggests that feelings of possessiveness towards knowledge may intervene in the willingness of an individual to disclose knowledge in a knowledge transfer process.
La muerte de una madre (2012)

espanolEn el ejercicio de nuestra labor asistencial como enfermeras nos encontramos con todo tipo de situaciones. La mayoria de ellas desagradables, donde el dolor y el sufrimiento estan latentes casi en todo momento. Como en este caso. La historia de las que le voy a hablar trata de como un dia me encontraba en el centro de salud donde trabajaba, cuando recibimos un aviso consistente en un accidente de trafico en el que la madre se desplazaba con sus tres hijos a la playa, donde pocos dias despues se reuniria con su marido. Ella murio en dicho accidente, los hijos por suerte no, apenas habian sufrido ningun dano fisico. Camino del hospital, trate de hablar con el nino al que acompanaba pero se mostraba reacio. Tras dejarlos en el hospital mas proximo, poco pude saber de ellos, excepto lo que me decia una companera que hacia guardias en tal hospital. Con este texto quise dar a pie a como vivi tal experiencia, por desgracia, no la unica en mi trayectoria profesional, pero si quizas una de la mas duras EnglishAbstract (The death of a mother) In the exercise of our welfare work as nurses we find all kinds of situations. Most of them unpleasant, where suffering and pain are latent almost at all times, like in this case. The story I'm going to tell you treats about how one day I was in the center where I worked, when we were informed of an accident where a mother was travelling towards the beach (she was going to meet his husband some days later). She died in this accident, fortunately her children did not, they had not suffered almost any damages. As we were going to the hospital, I tried to talk with the boy I was accompanying, but he did not want to. After leaving them in the nearest hospital, I could know only a little about them, except what one of my mates, who worked some nights there, told me. With this text, I just wanted to show you how I lived this experience, unfortunately, not the only one during my career, but maybe one of the hardest ones.
GROWTH AND MORPHOLOGY OF BaAlBO_3F_2 CRYSTALS (2005)

BaAlBO3F2 (BABF) crystals with sizes up to 18mm×18mm×12mm were grown with [001]-oriented seed using NaF as the flux. The suitable molar ratio for solute BaAlBO3F2 and NaF is 1/1. 5. During the growth of BABF, the cooling rate was 2 -4℃/d, and the rotation rate was 15 r/min. The morphology of BABF was studied. The predominant faces are (100) and (001). BABF was found to have powder second harmonic generation (SHG) efficiency about 0. 8 times of KH2PO4 (KDP). The grown BABF were subjected to microhardness measurement at room temperature. The microhardness values of BABF are 10. 99 GPa on the (001) plane and 8. 137 Gpa on the (100) plane.
Real-Time Specularity Detection Using Unnormalized Wiener Entropy (2013)

Specularity is a common phenomenon in the real world and can provide both challenges and opportunities for computer vision algorithms. In this paper, we propose a new method to detect specularities in real time. This method is based on an unnormalized version of the Wiener Entropy which is commonly used in audio spectral analysis. Experiment results demonstrate our proposed methodology's efficacy in specularity detection on both natural and synthetic images. Its potential in the 3D movie industry and for helping compute stereo correspondence in the presence of specularities is described.
Interactive Storytelling: A Player Modelling Approach (2007)

In recent years, the fields of Interactive Storytelling and Player Modelling have independently enjoyed increased interest in both academia and the computer games industry. The combination of these technologies, however, remains largely unexplored. In this paper, we present PaSSAGE (Player-Specific Stories via Automatically Generated Events), an interactive storytelling system that uses player modelling to automatically learn a model of the player's preferred style of play, and then uses that model to dynamically select the content of an interactive story. Results from a user study evaluating the entertainment value of adaptive stories created by our system as well as two fixed, pre-authored stories indicate that automatically adapting a story based on learned player preferences can increase the enjoyment of playing a computer role-playing game for certain types of players.
NMR Spectroscopic Studies of Palladium(II) Complexes of Bidentate Diphenylphosphane Ligands with Acetate and Tosylate Anions: Complex Formation and Structures (2009)

Abstract The synthetic pathways towards Pd II complexes of functionalized bidentate diphenylphosphane ligands of the type [Pd(ligand)(anion) 2 ] and [Pd(ligand) 2 ](anion) 2 have been investigated. Eighteen different ligands have been used in combination with strongly (acetate, OAc – ) or weakly (tosylate, OTs – ) coordinating anions. The solid‐state structure of some representative complexes was determined with X‐ray crystallography. It is shown that the solid‐state structures are fully retained in solution. The formation of [Pd(ligand)(anion) 2 ]‐type complexes was studied in detail by 1 H‐ and 31 P‐NMR spectroscopy. Depending on the ligand structure, the complex is formed instantaneously, via a polynuclear intermediate or is not formed at all. Complex formation is demonstrated to depend on the length and rigidity of the ligand backbone and on the steric bulk at the ortho position of the phenyl rings on phosphorus. It was also found that the coordinating ability of the anions can alter the structure of the kinetic and/or thermodynamic product.
VLSI design of a quaternary multiplier with direct generation of partial products (2002)

This paper presents the VLSI design of a novel quaternary multiplier with direct generation of partial products using a radix-4 redundant number system. The structure of the multiplier is so simple and regular that it is suitable for VLSI implementation. Partial products in the multiplier are generated as the corresponding value 0 to 9 and are implemented by simple CMOS current-mode circuits. To add partial products in the multiplier, we introduce a redundant multi-valued adder (RMA). The RMA can add two redundant numbers without carry propagation. The resulting numbers in the final level of additions are also redundant. We use a high speed quaternary carry-lookahead adder (QCLA) to convert a redundant number into a non-redundant number. The chip of a CMOS 4/spl times/4-digit quaternary multiplier is fabricated in cooperation with the VLSI Design and Education Center of Tokyo University, Japan. The chip and core sizes of the multiplier are 2.3/spl times/2.3 mm/sup 2/ and 1.5/spl times/1.6 mm/sup 2/, respectively with 1.5 /spl mu/m technology. The layout design of a 16/spl times/16-digit quaternary multiplier with 0.8 /spl mu/m technology is also discussed for the practical use.
Rare cells detection by selective enrichment with a novel multilayer concentric filter device (2014)

We develop a novel multilayer concentric filter device conjugated with an immune-binding method to achieve enrichment and detection of rare cells in a mass cell population by size based separation. Filter and size-based separation is one of the most efficient, simple and inexpensive method to isolate cells, but it encounters main disadvantages of clogs, cell deformation and insignificant size difference between targeted cell and normal cell. The concentric filter device and method used in this research were designed to create significant size difference and better separation efficiency by clogs reducing to identify rare cell with simple lab instrument. The target rare cells enrichment and detection from a mass cell population is successfully demonstrated by mixing 1:100,000 ratio of targeted MCF-7 and Jurkat cell. The device can be potentially applied for clinical Circulating Tumor Cells (CTCs) detection in the future.
Electron-beam fabrication of a 1.25 μm, 16-bit <i>I</i>2<i>L</i> microprocessor (1981)

E-beam direct slice writing has been utilized to fabricate a 55% linear shrink of the SBP9989, a 16-bit I2L microprocessor in the familiar TI SBP9900 series. The scaled device contains approximately 5 K gates and the chip area is 14.4 mm2 as compared with 37.1 mm2 for the full-sized chip. The chip layout is maintained in a database which can be easily manipulated to change design rules, scale selected geometries (pnp base width, collector size, etc.) or vary the overall scaling factor. The design requires minimum geometries of 1.25 μm and an overall process registration of ±0.75 μm. Patterns were delineated in TI-323A positive and TI-309 negative electron resists using EBMIII, a vector-scanned, laser-controlled electron beam exposure machine with a minimum beam diameter of 0.4 μm and level-to-level registration accuracy of &lt;±0.25 μm. The oxide-separated, double-level-metal fabrication process used ion implantation and anisotropic plasma etching to achieve maximum control of junction depths and etch profiles, respectively. Fabricated units were fully functional from −55 °C to +125 °C and showed a speed improvement of 2× at one-half the power of the full-size chip.
Density Functional Theory Study of Catechol Adhesion on Silica Surfaces (2010)

It has been speculated that the catechol (1,2-dihydroxybenzene) functionality of marine mussels is responsible for its strong and versatile adhesion on various wet surfaces. To elucidate features of this adhesion, we performed a periodic density functional theory calculation for catechol adsorption on silica surfaces. We obtained its binding energy and geometry on two representative hydroxylated surfaces of cristobalite, which mimic amorphous silica. Catechol strongly adhered to both surfaces by making three or four hydrogen bonds. Catechol achieved versatility in adhesion via torsion of its hydroxyls. The binding energy of catechol, which amounts to 14 kcal/mol, was larger than that of water, irrespective of the surface. With the inclusion of dispersion interaction, the binding energy of catechol further increased up to 33 kcal/mol, and its preferential adsorption over water became evident. Both the hydroxyls and phenylene ring of catechol contribute to its strong adhesion due to hydrogen bonds and dispersion.
El Caribe: movimientos político-poblacionales, 1950-1994 (2000)

Nuestro estudio pretende hacer hincapie no solo en aquellas politicas violentas o adversas que motivan los desplazamientos de personas, sino tambien en como los factores economicos, que en muchos casos los podemos encontrar encubiertos por motivaciones politicas, tambien son motivo de desplazamiento forzado y como en muchos momentos son confundidos o encubiertos unos en los otros para no darles el valor y la categoria que les corresponde, como lo podemos observar en los casos de Haiti y Cuba, que ejemplifican perfectamente esta cuestion y, sobre todo, caracterizan el tipo de movimiento de la poblacion
Chromosome rearrangements recovered following transformation of Neurospora crassa. (1993)

New chromosome rearrangements were found in 10% or more of mitotically stable transformants. This was shown for transformations involving a variety of different markers, vectors and recipient strains. Breakpoints were randomly distributed among the seven linkage groups. Controls using untransformed protoplasts of the same strains contained almost no rearrangements. A study of molecularly characterized Am+ transformants showed that rearrangements are frequent when multiple ectopic integration events have occurred. In contrast, rearrangements are absent or infrequent when only the resident locus is restored to am+ by a homologous event. Sequences of the transforming vector were genetically linked to breakpoints in 6 of 10 translocations that were examined using Southern hybridization or colony blots.
Color filters integrated with the detector in silicon (1987)

The usual single-chip color imager consists of an alternating pattern of three types of color filters deposited on top of a regular array of photodetectors. The novel principle to be presented is comprised of a method for integrating the filtering element with the photodetector in silicon, which reveals an intrinsic color filtering capability based on the strong wavelength dependence of the absorption coefficient. The band-pass central wavelength of the optical filter is electronically tunable using the reverse voltage applied across the diode, so that only one diode is required for each color element.
Polar bodies—more a lack of understanding than a lack of respect (2010)

Polar bodies are as diverse as the organisms that produce them. Although in many animals these cells often die following meiotic maturation of the oocyte, in other organisms they are an essential and diverse part of embryonic development. Here we highlight some of this diversity and summarize the evolutionary basis for their utility.
ChemInform Abstract: Synthesis and Characterization of Alkyl‐, Halo‐ and Heterosubstituted Derivatives of the Potent Phototoxin α‐Terthienyl. (1988)

Abstract A series of derivatives of the known phototoxic title compound (I) including the compounds (III), (IV), (V), (X), (XI), (XII), (XIV), and (XV) are synthesized as outlined in the scheme.
Distribution pattern of tenascin‐C in normal and neoplastic mesenchymal tissues (1997)

Descriptions for tenascin-C distribution are largely restricted to epithelial tumours. The present study utilized newly developed and characterized monoclonal (hT191) and polyclonal antibodies to investigate the distribution pattern of tenascin-C in a panel of mesenchymal tumours, which was contrasted with normal tissue. The specific antibodies recognized the distinctive star-like hexabrachion protein isolated from transformed cell-culture medium and serum from normal individuals. In normal tissues, a strong tenascin-C expression in the extracellular matrix was largely restricted to basement-membrane regions of epithelium and tonsilar sinusoids, pericellularly within smooth-muscle bundles, associated with perimysial, -chondrial, -neurial and -tendon surfaces, and diffusely within vascular adventitia. It was found in the corresponding tumours of the neural sheath (schwannoma) and smooth muscle (leiomyosarcoma), and was abundantly present around certain blood vessels of mesenchymal tumours. Although not detected in normal muscle, or in adipose or fibrous connective tissue, neo-expression of tenascin-C was shown in more than half of the rhabdomyosarcomas, fibromas and liposarcomas, with an increased positive percentage in variably malignant myxoid liposarcomas compared with lipoma-like sarcomas. Tenascin-C was typically found in the extracellular matrix of soft-tissue tumours, but was notably absent from the epithelial-cell components of mixed epithelial/mesenchymal tumours. Its apparently enhanced expression in soft-tissue tumours differs from that of most other large extracellular-matrix proteins, suggesting possible functional involvement of the cell-adhesion molecule, tenascin-C, in the neoplastic phenotype.
Extracorporeal liver support (2011)

therapy to study, prognosis and liver transplantation. Because of its central role the prognosis of liver failure is poor and is finally dependent upon restoration of sufficient liver function to reverse the consequences listed above.