gebhart/patrepeval huggingface dataset:
A new approach for initialization sequences computation for synchronous sequential circuits (1997)

This paper presents a new approach to the automated generation of an initialization sequence for synchronous sequential circuits. Finding an initialization sequence is a hard task when a global reset signal is not available, and functional techniques often cannot handle large circuits. We propose a Genetic Algorithm providing a sequence that aims at initializing the highest number of flip flops with the lowest number of vectors. The experimental results we provide shore that the approach is feasible to be applied even to the largest benchmark circuits and that it compares well to other known approaches in terms of initialized flip flops and sequence length.
Synthesis of Mixed Opioid Affinity Cyclic Endomorphin-2 Analogues with Fluorinated Phenylalanines (2015)

As part of our continuing studies on the structure-activity relationships of cyclic pentapeptides based on the structure of endomorphin-2 (EM-2), we report here the synthesis and biological activities of a new series of analogues of a general sequence Tyr/Dmt-c[d-Lys-Phe-Phe-Asp]NH2 (where Dmt = 2',6'-dimethyltyrosine), incorporating fluorinated amino acids: 4-fluorophenylalanine (4-F-Phe), 2,4-difluorophenylalanine (2,4-F-Phe), or 4-trifluoromethylphenylalanine (4-CF3-Phe) instead of the Phe residue in position 3 or 4. Depending on the fluorinated amino acid residue and its position in the sequence, analogues were mixed, high affinity MOP/KOP receptor agonists, MOP/DOP/KOP agonists, or selective KOP agonists. The in vitro potencies and efficacies of all novel analogues were assessed in calcium mobilization assay. The most potent analogues, Dmt-c[d-Lys-Phe-4-F-Phe-Asp]NH2 and Dmt-c[d-Lys-Phe-2,4-F-Phe-Asp]NH2, were tested in vivo in the mouse hot-plate test. They produced strong antinociceptive effect not only after intracerebroventricular but also after intraperitoneal injection, indicating that they were able to cross the blood-brain barrier.
A Non-Negative Quadratic Programming Approach To Minimize The Generalized Vector-Valued Total Variation Functional (2010)

Publication in the conference proceedings of EUSIPCO, Aalborg, Denmark, 2010
Analysis of HRT Images: Comparison of Reference Planes (2008)

Compared to the standard RP, the Moorfields RP has significantly lower variability and probably provides a greater facility for discriminating RA change from measurement variability in a longitudinal HRT image series.
Anatomy of Schizophrenia Revisited (1997)

The search for an anatomy of schizophrenia has engendered an enormous, almost indigestible mass of data. In no studies do all patients show the same deviations from control samples. No morphological or microscopic abnormality has been found that is either necessary or sufficient for the diagnosis. In contrast to epilepsy, in which a proliferation of excitatory pathways or inadequate inhibitory factors are paramount, schizophrenia may represent a genetically and age-determined elaboration of one or more inhibitory networks in response to specific physiological events (e.g., the increased neuronal activity in limbic and hypothalamic structures during the physiological events of puberty) or to brain injury or defect. Current diagnostic classifications, including the positive-negative categories, have not led to separation of the disorder into etiologically or pathologically similar subgroups. Analysis of morphological and other biological pathology by a different nosological principle, such as trajectory of the illness, and separate correlation of anatomical and other biological outliers with clinical and demographic factors may be more successful strategies than pooling and averaging results from a mixture of patients diagnosed with schizophrenia.
U.S. Food and Drug Administration Approval Summary: Ramucirumab for the Treatment of Metastatic Non-Small Cell Lung Cancer Following Disease Progression On or After Platinum-Based Chemotherapy (2015)

This report presents key information on the U.S. Food and Drug Administration approval of ramucirumab, a monoclonal antibody targeting vascular endothelial growth factor receptor-2, given in combination with docetaxel for the treatment of patients with metastatic non-small cell lung cancer whose disease has progressed on or after platinum-based chemotherapy. This report specifically addresses the issues of safety in patients with squamous cell tumors, effect of treatment in elderly patients, and uncertainties regarding effects in patients with tumors harboring epidermal growth factor receptor or anaplastic lymphoma kinase genomic tumor aberrations.
Protease Inhibitors Fail To Prevent Pore Formation by the Activated <i>Bacillus thuringiensis</i> Toxin Cry1Aa in Insect Brush Border Membrane Vesicles (2006)

To investigate whether membrane proteases are involved in the activity of Bacillus thuringiensis insecticidal toxins, the rate of pore formation by trypsin-activated Cry1Aa was monitored in the presence of a variety of protease inhibitors with Manduca sexta midgut brush border membrane vesicles and by a light-scattering assay. Most of the inhibitors tested had no effect on the pore-forming ability of the toxin. However, phenylmethylsulfonyl fluoride, a serine protease inhibitor, promoted pore formation, although this stimulation only occurred at higher inhibitor concentrations than those commonly used to inhibit proteases. Among the metalloprotease inhibitors, o-phenanthroline had no significant effect; EDTA and EGTA reduced the rate of pore formation at pH 10.5, but only EDTA was inhibitory at pH 7.5. Neither chelator affected the properties of the pores already formed after incubation of the vesicles with the toxin. Taken together, these results indicate that, once activated, Cry1Aa is completely functional and does not require further proteolysis. The effect of EDTA and EGTA is probably better explained by their ability to chelate divalent cations that could be necessary for the stability of the toxin's receptors or involved elsewhere in the mechanism of pore formation.
Lattice Boltzmann Method for Simulation of Shale Gas Transport in Kerogen (2012)

Summary Fluid mechanics of natural gas in organic-rich shale involves nanoscale phenomena that could lead to potential non-Darcy effects during gas production. In general, these are low-Reynolds-number and noncontinuum effects and, more importantly, pore-wall-dominated multiscale effects. In this study, we introduce a new lattice Boltzmann method (LBM) to investigate these effects numerically in simple pore geometries. The standard method was developed in the 1980s to overcome the weaknesses of lattice gas cellular automata and has emerged recently as a powerful tool to solve fluid dynamics problems, in particular in the areas of micro- and nanofluidics. The new approach takes into account molecular-level interactions by use of adsorptive/cohesive forces among the fluid particles and defining a Langmuir-slip boundary condition at the organic pore walls. The model allows us to partition mass transport by the walls into two components: slippage of free gas molecules and hopping (or surface transport) of the adsorbed gas molecules. By use of the standard 2D D2Q9 lattice, low-Reynolds-number gas dynamics is simulated in a 100-nm model organic capillary and later in a bundle of smaller-sized organic nanotubes. The results point to the existence of a critical Knudsen-number value for the onset of laminar gas flow under typical shale-gas-reservoir pressure conditions. Beyond this number, the predicted velocity profile shows that the mechanisms of slippage and surface transport could lead to molecular streaming by the pore walls, which enhances the gas transport in the organic nanopores. The work is important for development of new-generation shale-gas-reservoir flow simulators, and it can be used in the laboratory for organic-rich-shale characterization.
Surface energy relations in liquid/solid systems I. The adhesion of liquids to solids and a new method of determining the surface tension of liquids (1942)

Abstract A new method for determining the surface tension of liquids has been derived. This involves the consideration of the advancing and receding contact angles of a liquid drop on a tilted solid surface. The theory has been tested by an improved optical projection technique for a variety of liquid/ solid systems and the results obtained are in agreement with the accepted values. It is shown that the advancing and receding contact angles are characteristic constants of liquid/solid system s and the calculated and measured values of the minimum receding angles are in agreement. The prevailing views of ‘hysteresis’ effects or ‘stationary’ contact angles which have arisen to account for the data available are incorrect and the discordant experimental results reported are due to inadequate technique. The difference between the adhesions corresponding to the advancing and receding angles is ascribed to the work done in removing an adsorbed unimolecular layer. The work done in gcal./mol. in forming this adsorbed layer is in reasonable agreement with that expected from studies in gas/solid systems and the forces involved are van der Waals’. Further, different solids that might be expected to show similar surface structures yield similar values for the work done. The variation in the value of the advancing angle in some liquid/solid systems and its constancy in others is reconciled with the polar character of the solid surface, i.e. it is suggested that short-range forces are involved. It has been found that monolayers of ferric stearate on glass are orientated with their hydrocarbon tails away from the interface in agreement with electron diffraction measurements. It is suggested that the methods may be useful for investigating the structure of monofilms and built-up layers of monofilms.
Silver‐Catalyzed Oxidative Activation of Benzylic CH Bonds for the Synthesis of Difluoromethylated Arenes (2014)

A mild and catalytic method to form difluoromethylated arenes through the activation of benzylic C-H bonds has been developed. Utilizing AgNO3 as the catalyst, various arenes with diverse functional groups undergo activation/fluorination of benzylic C-H bonds with commercially available Selectfluor reagent as a source of fluorine in aqueous solution. The reaction is operationally simple and amenable to gram-scale synthesis.
α-Smooth Muscle Actin Distribution in the Pulmonary Vasculature Comparing Hypoplastic and Normal Fetal Lungs (1998)

We investigated the intra-acinar pulmonary vascular muscularization in the developing human fetal lung between the 17th and 24th gestational weeks, that is, during the canalicular phase of lung development. Fifteen hypoplastic and 25 normal developed lungs were included in this study using monoclonal alpha-smooth muscle (sm) actin antibodies for smooth muscle detection. Computer-aided image analysis was performed for morphometrical measurements and statistical evaluation. Alpha-sm-actin-immunoreactive intra-acinar vessels down to a luminal diameter of less than 10 microns were detected in hypoplastic as well as in normally developed lungs. Crucial differences presented as follows: significantly higher density of intra-acinar vessels, especially due to alpha-sm-actin-negative vessels less than 30 microns in luminal diameter, in the control group; significantly higher alpha-sm-actin immunore-activity per section unit as well as per vessel in the hypoplastic lung group. As suggested by others, alpha-sm-actin-positive cells of the intra-acinar vessel wall in the developing human lung were demonstrated to be smooth muscle cells, their immediate precursors, and pericytes. We conclude that the increased alpha-sm-actin immunoreactivity represents muscularization of the vessel wall in functional terms and may be regarded as one structural cause among others for the establishment of persistent fetal circulation in hypoplastic lungs.
New Light on Arianism (1982)

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Involvement of the SREBP pathway in the mode of action of androgens in sebaceous glands <i>in vivo</i> (2003)

Androgens have profound effects on the physiology of the sebaceous gland. Using the hamster ear sebaceous gland model, we performed a detailed kinetic study to clarify the mechanism of androgen action on sebaceous gland function. We demonstrated that the growth of sebaceous glands observed after androgen treatment was due to both an increase in sebocyte proliferation and a parallel induction of sebocyte terminal differentiation, as evidenced by the induction of the synthesis of specific sebaceous lipids such as cholesterol esters, triglycerides, and squalene. Accordingly, the effect of androgen treatment on the mRNA expression of several key enzymes involved in the synthesis of sebaceous lipids has been studied using semi-quantitative RT-PCR. Up-regulation by androgens of mRNA expression of HMG coenzyme A synthase and reductase, acetyl coenzyme A carboxylase (ACC), glycerol 3-phosphate acyl transferase (GPAT), and FAR-17c (stearoyl coenzyme A desaturase homologous), was demonstrated. Because sterol-response element(s) (SREs) are known to be present in the promoters of these genes, we analyzed the expression by RT-PCR and the activation of the transcription factor sterol regulatory element binding protein (SREBP) using immunoblotting experiments. Our results showed that SREBP-1 was up-regulated and rapidly activated after androgen treatment. Altogether, these results demonstrate for the first time that in sebaceous glands, in vivo, androgen regulates the synthesis of sebum lipids through the SREBP pathway.
Functional Living Trileaflet Heart Valves Grown In Vitro (2000)

Background —Previous tissue engineering approaches to create heart valves have been limited by the structural immaturity and mechanical properties of the valve constructs. This study used an in vitro pulse duplicator system to provide a biomimetic environment during tissue formation to yield more mature implantable heart valves derived from autologous tissue. Methods and Results —Trileaflet heart valves were fabricated from novel bioabsorbable polymers and sequentially seeded with autologous ovine myofibroblasts and endothelial cells. The constructs were grown for 14 days in a pulse duplicator in vitro system under gradually increasing flow and pressure conditions. By use of cardiopulmonary bypass, the native pulmonary leaflets were resected, and the valve constructs were implanted into 6 lambs (weight 19±2.8 kg). All animals had uneventful postoperative courses, and the valves were explanted at 1 day and at 4, 6, 8, 16, and 20 weeks. Echocardiography demonstrated mobile functioning leaflets without stenosis, thrombus, or aneurysm up to 20 weeks. Histology (16 and 20 weeks) showed uniform layered cuspal tissue with endothelium. Environmental scanning electron microscopy revealed a confluent smooth valvular surface. Mechanical properties were comparable to those of native tissue at 20 weeks. Complete degradation of the polymers occurred by 8 weeks. Extracellular matrix content (collagen, glycosaminoglycans, and elastin) and DNA content increased to levels of native tissue and higher at 20 weeks. Conclusions —This study demonstrates in vitro generation of implantable complete living heart valves based on a biomimetic flow culture system. These autologous tissue-engineered valves functioned up to 5 months and resembled normal heart valves in microstructure, mechanical properties, and extracellular matrix formation.
REVIEWS OF BOOKS (1995)

Journal Article REVIEWS OF BOOKS Get access The Halt in the Mud: French Strategic Planning from Waterloo to Sedan. By Gary P. Cox. Boulder, Colo and Summertown, Oxford: Westview Press. 1994. 258 + xii pp. £33.50. ISBN 0 8133 1536 0. PADDY GRIFFITH PADDY GRIFFITH Nuneaton Search for other works by this author on: Oxford Academic Google Scholar French History, Volume 9, Issue 2, June 1995, Pages 250–252, https://doi.org/10.1093/fh/9.2.250 Published: 01 June 1995
Cyclic sulfamate from N-substituted 2-amino-3-phenyl-1-propanol and its nucleophilic reactions (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclic sulfamate from N-substituted 2-amino-3-phenyl-1-propanol and its nucleophilic reactionsGregory J. White and Michael E. GarstCite this: J. Org. Chem. 1991, 56, 9, 3177–3178Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/jo00009a045https://doi.org/10.1021/jo00009a045research-articleACS PublicationsRequest reuse permissionsArticle Views657Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Evaluation of drug treatment in irritable bowel syndrome (2003)

The irritable bowel syndrome (IBS) remains a therapeutic challenge in part because of the limited understanding of the pathophysiology. The placebo response rate varies in randomized controlled trials from 20 to 70%, and can persist for up to at least 1 year. It is contentious whether dietary fibre and bulking agents relieve the symptoms of IBS; constipation probably improves. Anticholinergic and antispasmodic agents are of questionable benefit in IBS despite positive meta-analyses of poor quality trials. A meta-analysis concluded that the tricyclic antidepressants were superior to placebo in IBS, although the individual trial results were variable. Selective serotonin reuptake inhibitors are of uncertain benefit. Laxatives are used for constipation but probably poorly control the IBS symptom complex. Loperamide is superior to placebo in improvement of diarrhoea but not abdominal pain in IBS. Tegaserod is a well- tolerated aminoguanidine indole derivative of serotonin that is a partial 5HT4-receptor agonist with prokinetic properties; a therapeutic gain over placebo of 5% to 15% has been observed in constipation-predominant IBS in females. Alosetron is a 5HT3-receptor antagonist that is efficacious in females with diarrhoea-predominant IBS, with a 12% to 17% therapeutic gain; the risk of ischaemic colitis is 1 in 350, with very severe constipation occurring in about 1 in 1000. Optimizing study design remains a challenge in IBS. New visceral analgesic and motility modifying agents, as well as anti-inflammatory agents are in trials, and hopefully additional efficacious therapeutic options for patients with IBS will soon emerge.
Profesionales de la Información dentro de la Sociedad de la Información (2006)

CELSO GONZALES CAM es egresado de la especialidad de Bibliotecologia y Ciencias de la Informacion de la Pontificia Universidad Catolica del Peru. Se ha especializado en administracion de redes y actualmente se desempena como webmaster de la Universidad del Pacifico. Ademas, es profesor del curso de Tecnologia de la Informacion en la especialidad de Ciencias de la Informacion de la PUCP.
Electrical characteristics of the interface between the top Si and buried oxide in ITOX-SIMOX wafers (2002)

Summary form only given. High-quality ITOX-SIMOX (internal thermal oxidation-SIMOX) wafers (Nakashima et al, 1994) have been used for the fabrication of 0.25 /spl mu/m fully-depleted CMOS-SIMOX LSIs (Ino et al, 1996). In fully-depleted devices, device performance strongly depends on the quality of the interface between the top Si and the buried oxide (top Si-buried oxide interface) as well as that of the gate oxide-top Si interface. However, there are few reports on the electrical characteristics of the top Si-buried oxide interface. Accordingly, we fabricated a buried MOS diode, which has a P/sup +/ gate beneath the buried oxide, in ITOX-SIMOX wafers and investigated the electrical characteristics of the interface. The obtained results reveal that the fixed charge density Q/sub f//q and the interface trap density D/sub it/ are extremely small, and are comparable to those of thermal oxide. These results indicate that the ITOX-SIMOX wafer has a high quality top Si-buried oxide interface, and the reduced pinhole density and high quality interface of ITOX-SIMOX wafers are useful for the fabrication of fully-depleted CMOS-SIMOX LSIs.
Laser ray-tracing method for optical testing (1999)

We have developed a novel laser ray-tracing method to measure aberrations in optical systems. It consists of delivering narrow laser pencils (by a laser scanner), recording the spots that are formed on the image plane (with a CCD camera), and computing the position of each centroid. This approach could be considered an experimental (approximate) implementation of standard numerical ray tracing. Several tests and experiments, including a direct comparison with a Hartmann-Shack wave-front sensor, provided highly satisfactory results that confirmed the validity of the method and revealed potential advantages.
DRAFT: an on-line fault detection method for dynamic and partially reconfigurable FPGAs (2002)

Reconfigurable systems have benefited from the novel partial dynamic reconfiguration features of recent FPGA devices. Enabling the concurrent reconfiguration without disturbing system operation, this technology has raised a new test challenge: to assure a continuously fault free operation, independently of the circuit present after many reconfiguration processes, testing the FPGA without disturbing the whole system operation. Re-using the IEEE 1149.1 infrastructure, already widely used for In-System Programming, and exploiting the same dynamic and partially reconfigurable features underlying this test challenge, this paper develops a new structural concurrent test approach able to detect faults and introduce fault tolerance features, without disturbing system operation, in the field and throughout its lifetime.
Cross-Device Tracking: Matching Devices and Cookies (2015)

The number of computers, tablets and smartphones is increasing rapidly, which entails the ownership and use of multiple devices to perform online tasks. As people move across devices to complete these tasks, their identities becomes fragmented. Understanding the usage and transition between those devices is essential to develop efficient applications in a multi-device world. In this paper we present a solution to deal with the cross-device identification of users based on semi-supervised machine learning methods to identify which cookies belong to an individual using a device. The method proposed in this paper scored third in the ICDM 2015 Drawbridge Cross-Device Connections challenge proving its good performance.