gebhart/patrepeval huggingface dataset:
Current status of FK 506 in liver transplantation. (1991)

In 1987 Ochiai and coworkers presented a report on the immunosuppressive qualities of a new immunosuppressive agent, FK 506, isolated from the fermented broth of a soil fungus, Streptomyces tsukubaensis.1 Extensive in vitro studies demonstrated the effectiveness in suppressing mixed lymphocyte cultures, presumably by inhibiting 1L-2 synthesis following ailoactivation.2 The receptor for FK 506 has been identified and has been characterized as a peptidyl-prolyl cis-trans isomerasc.3

The background for the clinical development of FK 506 was well documented by Starzi in the opening remarks of a satellite symposium on FK 506, held in Barcelona, Spain, in November 1989 as part of the European Society of Organ Transplantation.4 In vivo studies using a number of animal models have shown a marked ability to prevent rejection following various types of organ transplants.5-7 More interestingly, FK 506 possesses the ability to reverse ongoing rejection in animal models.7,8 This characteristic is unique, since it is well known that cyclosporine (CyA) will not reverse established ongoing rejection. These properties served as the initiative to pursue clinical testing of FK506.

The objective of this report is to update the reader on the current status of the use of FK 506 in liver transplantation at the University of Pittsburgh. One phase of the study consists of the “rescue” with FK 506 of liver allografts undergoing rejection with CyA-based immunosuppression.9 The second phase of the report consists of the results of primary liver transplantation using FK 506.10
Adaptive beamforming for moving array with 3-axis electronic compass in hearing aids (2009)

People who use digital hearing aids with directional microphones want to listen target sounds selectively, whether the speaker is remote or nearby. We have proposed a steerable microphone array technique that combines omnidirectional and directional microphone signals with 3-axis electronic compass. When the user moves the array toward a desired sound source, the microphone array can be steered while fast and slow head movements. The 3-axis electronic compass can be built in hearing aids to generate coordinates of a microphone in array. When array moves, the adaptive beamformer uses the geometry information to find optimal solution for enhancing the sound quality such as Speech Intelligibility.
Phase Transitions in Ferroelastic and Co-elastic Crystals (1991)

This textbook describes the fundamental principles of structural phase transitions in materials in an easily understandable form, suitable for both undergraduate and graduate students. Ferroelasticity, twinning and related microstructures are described. Landau-type theories of phase transitions are introduced, together with details of elastic and specific heat anomalies, the formation of spontaneous strain, and the generation of solitary waves at temperatures close to the transition point. Many materials used in industry are crystals. These crystals often show anomalies such as sudden softening or embrittlement at certain temperatures; if controlled, such behaviour can be extremely useful for manufacturing and high technology applications. This is one of the first books to describe the recently determined physical origins of such behaviour, and provides an insight into the important thermodynamic principles and microstructural properties involved.
Organotin polymers formed by glow-discharge polymerization (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganotin polymers formed by glow-discharge polymerizationErich Kny, Leonard L. Levenson, William J. James, and Robert A. AuerbachCite this: J. Phys. Chem. 1980, 84, 12, 1635–1638Publication Date (Print):June 1, 1980Publication History Published online1 May 2002Published inissue 1 June 1980https://doi.org/10.1021/j100449a039Request reuse permissions Article Views86Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Synthetic Study of a(2,8) Oligosialoside Using N-Troc Sialyl N-Phenyltrifluoroimidate (2006)

An effective approach for the synthesis of oligo-α(2,8) sialosides using N-Troc sialyl donors is described.Glycosylation of N-Troc sialoside with N-Troc sialyl N-phenyltrifluoroimidate and phosphites smoothly proceeded to provide α(2,8) disialosides in good yield and selectivity.Sialic acids such as Neu5Ac, Neu5Gc and KDN, are often located at the non-reducing end of glycoconjugates on the cell surface through α-glycosidic bonds, and play a central role in cell surface recognition phenomena. 1Recently, poly-and oligo-sialosides composed of the α(2,8) disialyl unit (1) are found in many glycoproteins as well as glycolipids, and would be important fragments to bind proteins as well as monomeric sialic acid. 2 However, low availability of the pure sialo-containing glycoconjugates from the natural sources makes it difficult to elucidate their biological activity, and requires an effective methodology for the synthesis of α(2,8) sialosides.
Performance evaluation of vision-based lane sensing: some preliminary tools, metrics, and results (2002)

The growth in the number of vision-based lane sensing algorithms in the literature has far outpaced the development of methods for characterizing the limits of performance of such algorithms. The large amounts of data such systems will need to correctly process to be sufficiently reliable for commercial deployment requires that tools be developed for the evaluation process which are almost completely automated. In order to gain some insight into the issues involved, a small pilot study was performed to compare the reliability of two methods used by the YARF road tracking system for locating white painted stripes in small image windows. The evaluation methodology and results are described. In addition, several proposed metrics for measuring road detectability are defined and evaluated.
Ethnicity and Peripheral Arterial Disease (2005)

Black ethnicity was a strong and independent risk factor for PAD, which was not explained by higher levels of diabetes, hypertension, and body mass index. There was no evidence of a greater susceptibility of blacks to cardiovascular disease risk factors as a reason for their higher PAD prevalence. Thus, the excess risk of PAD in blacks remains unexplained and requires further study.
The virD operon of Agrobacterium tumefaciens Ti plasmid encodes a DNA-relaxing enzyme. (1989)

The virD locus of Agrobacterium tumefaciens Ti plasmid encodes functions necessary for endonucleolytic cleavage of transferred DNA (T-DNA) prior to its transfer to plant cells. For the overproduction of the VIRD proteins in Escherichia coli a tac-virD operon fusion was constructed. A significant increase in the accumulation of VIRD proteins was observed in a lon protease-deficient E. coli host. The presence of an overlapping open reading frame (ORF) upstream of the VIRD1 coding sequence had a negative effect on VIRD1 production. A preparation containing VIRD proteins catalyzes the conversion of supercoiled (form I) DNA to relaxed (form IV) DNA. This activity is similar to that of a DNA topoisomerase. The relaxation activity lacks DNA sequence specificity, requires magnesium ion, and has no requirement for an energy source. Studies with plasmids that had lost defined DNA segments encompassing various virD coding regions showed that VIRD1 is the DNA-relaxing enzyme. In a density gradient centrifugation experiment, the DNA-relaxing activity sedimented as a 21-kDa polypeptide. Earlier studies of Jayaswal et al. [Jayaswal, R., Veluthambi, K., Gelvin, S. & Slightom, J. (1987) (J. Bacteriol. 169, 5035-5045] have shown that in E. coli VIRD2 alone is not sufficient for endonucleolytic cleavage of T-DNA and requires VIRD1 for its activity.
Seasons Changing (2001)

through a Lucky Strike, than in ambling along the roadside at a playpretend job. When "black lung" was honored with a name, the state's lawyers spotted the gold behind it and began enlisting miners in their cause (one Eastern Kentucky lawyer, in three years of handling black lung cases, made two and a half million dollars). Ferd Runnel, always an obliging fellow, applied for benefits, though he had worked in a truck mine only a few weeks. He was let go when the coal market went into a slump. The day Ferd had his medical exam he was a bit nervous, a buddy who went with him reported. He arrived at the doctor's office early and chain-smoked until the nurse called him in. His lungs were so clogged with Lucky Strikes, he successfully failed the breathing test with room to spare. As if to make sure he getting his point across, he died before his claim could be processed. Millie Runnel was awarded enough money to buy a house trailer and a lot on the edge of town. Of course this was going too far. Her new neighbors made remarks behind her back. They could've overlooked a little butter and cheese, free school lunches for her children. Not one of them would've refused to chip in on the gingerbread if asked. Ferd never did anything to deserve all that money, they said. It's awful what our country's come to. Seasons Changing From the field below he'd passed clumps of cresses, frosted that morning. Across an old foot log he stepped carefully, slowly, where moss indented the surface. Life lay here and there, bunched in trout lilies, mottled, yellow flowers flirting, turkey mustard and sprigs of wintergreen. By rocks piled in a new field's plowed beginnings, the quick green of a garter snake slithered by like a girl's wind-frightened ribbon. In the season changing, it could have been a copperhead awakening. Where sarvis trees shroud a hill white, the chill had a bite. —John Cantey Knight 19 ...
Antiviral Activity of<i>Isatis indigotica</i>Extract and Its Derived Indirubin against Japanese Encephalitis Virus (2012)

Isatis indigotica is widely used in Chinese Traditional Medicine for clinical treatment of virus infection, tumor, and inflammation, yet its antiviral activities remain unclear. This study probed antiviral activity of I. indigotica extract and its marker compounds against Japanese encephalitis virus (JEV). I. indigotica methanol extract, indigo, and indirubin proved less cytotoxic than other components, showing inhibitory effect (concentration-dependent) on JEV replication in vitro. Time-of-addition experiments proved the extract, indigo, and indirubin with potent antiviral effect by pretreatment (before infection) or simultaneous treatment (during infection), but not posttreatment (after entry). Antiviral action of these agents showed correlation with blocking virus attachment and exhibited potent virucidal activity. In particular, indirubin had strong protective ability in a mouse model with lethal JEV challenge. The study could yield anti-JEV agents.
Daniel Rabreau, La saline royale d'Arc-et-Senans. Un monument industriel : allégorie des Lumières. Paris, Belin-Herscher, 2002 (2003)

Morin Christophe. Daniel Rabreau, La saline royale d'Arc-et-Senans. Un monument industriel : allégorie des Lumières. Paris, Belin-Herscher, 2002. In: Bulletin Monumental, tome 161, n°3, année 2003. p. 272.
An introduction to intelligent and autonomous control (1993)

Part 1 Theory and architectures: introduction to intelligent control systems with high degrees of autonomy, P.A. Antsaklis and K.M. Passino a reference model architecture for intelligent systems design, J.S. Albus model-based architecture concepts for autonomous systems design and simulation, B.P. Zeigler and Sungdo Chi design of structure-based hierarchies for distributed intelligent control, L. Acar and U. Ozguner modelling and design of distributed intelligence systems, A.H. Levis nested hierarchical control, A. Meystel. Part 2 Design approaches and techniques: expert control, K.J. Astrom and K.-E. Arzen modelling and analysis of artificially intelligent planning systems, K.M. Passino and P.J. Antsaklis fuzzy and neural control, H.R. Berenji learning control systems, J.A. Farrell and W. Baker learning control methods, needs and architectures, M.M. Kokar learning in control, E. Grant. Part 3 Applications: intellingent robot prehension, Thang N. Nguyen and H. Stephanou modelling of multi-sensory robotic systems with failure diagnostic capabilities, K.P. Valavanis and G. Seetharaman AUTOCREW - a paradigm for intelligent flight control, B.L. Belkin and R.F. Stengel a framework for knowledge-based diagnosis in process operations, P.R. Prased and J.F. Davis.
Legolizer: A Real-Time System for Modeling and Rendering LEGO Representations of Boundary Models (2009)

In this work we propose a method for converting triangular meshes into LEGO <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> bricks through a voxel representation of boundary meshes. We present a novel voxelization approach that uses points sampled from a surface model to define which cubes (voxels) and their associated colors will compose the model. All steps of the algorithm were implemented on the GPU and real-time performance was achieved with satisfactory volumetric resolutions. Rendering results are illustrated using realistic graphics techniques such as screen space ambient occlusion and irradiance maps.
Quantitative Microfluidic Separation of DNA in Self-Assembled Magnetic Matrixes (2004)

We present an experimental study of the microfluidic electrophoresis of long DNA in self-assembling matrixes of magnetic bead columns. Results are presented for the rapid separation of lambda-phage, 2lambda-DNA, and bacteriophage T4 DNA, where separation resolutions greater than 2 between lambda and T4 are achieved in times as short as 150 s. The use of a computer-piloted flow control system and injection results in high reproducibility between separations. We compare the experimentally measured mobility and dispersion with an exactly solvable lattice Monte Carlo model. The theory predicts that the mean velocity scales linearly with the field, the band broadening scales with the inverse of the field, and the resolution is independent of the field for intermediate fields-all of which are in accord with the experimental results. Moreover, reasonable quantitative agreement is achieved for band broadening for longer DNA (2lambda and T4) when the average postengagement time is measured experimentally. This work demonstrates the possibility of achieving fast microfluidic separation of large DNA on a routine basis.
Amniotic Fluid Defensins: Potential Markers of Subclinical Intrauterine Infection (1998)

Human neutrophil peptides 1-3 (defensins) are granule constituents released from activated neutrophils. We hypothesized that amniotic fluid (AF) defensin levels are elevated in preterm labor (PTL) patients with subclinical intrauterine infection (IUI). AF samples were obtained from 203 pregnant patients with varying clinical characteristics. Defensin levels were measured by enzyme-linked immunosorbent assay. Median AF defensin levels were fourfold to 24-fold higher in patients with IUI than in preterm and term controls. Among patients with subclinical IUI, the degree of AF defensin elevation was greater in those with a positive AF culture. AF defensin levels increased exponentially with increasing severity of histologic chorioamnionitis. An AF defensin level of > 2,500 ng/mL identified 88% of patients with a positive AF culture, whereas a level of > 400 ng/mL identified 85% of all infected patients. AF defensin levels accurately identify patients with subclinical IUI, as defined by a positive AF culture or placental histology.
1.5 μm phase-shifted DFB lasers for single-mode operation (1984)

Fabrication and single-mode laser oscillation were demonstrated for modified DFB lasers where the phase of the corrugations was shifted at the centre by a quarter guided-wavelength and which, in principle, provided a resonance at the Bragg wavelength and stable single-mode oscillation. Phase-shifted corrugations were fabricated using electron-beam lithography.
A Review of Implantable Patch Antennas for Biomedical Telemetry: Challenges and Solutions [Wireless Corner] (2012)

Biomedical telemetry permits the transmission (telemetering) of physiological signals at a distance. One of its latest developments is in the field of implantable medical devices (IMDs). Patch antennas currently are receiving significant scientific interest for integration into the implantable medical devices and radio-frequency (RF)-enabled biotelemetry, because of their high flexibility in design, conformability, and shape. The design of implantable patch antennas has gained considerable attention for dealing with issues related to biocompatibility, miniaturization, patient safety, improved quality of communication with exterior monitoring/control equipment, and insensitivity to detuning. Numerical and experimental investigations for implantable patch antennas are also highly intriguing. The objective of this paper is to provide an overview of these challenges, and discuss the ways in which they have been dealt with so far in the literature.
Electrostatically Driven Touch-Mode Poly-SiC Microspeaker (2007)

This paper presents an electrostatically driven microspeaker utilizing a SiC membrane operating in the touch-mode configuration. The device is formed using conventional wafer bonding to hermetically seal a low-stress, heavily-doped polycrystalline 3C-SiC (poly-SiC) membrane to a bulk micromachined silicon back-plate containing a thin oxide insulating layer. The bonding process is done in high vacuum, causing the poly-SiC membrane to flex down into contact with the back-plate when exposed to atmospheric pressure. Sound Pressure Level (SPL) measurements were recorded for a device with a poly-SiC membrane thickness of 1 mum, a diameter of 800 mum, and a diaphragm/back-plate spacing of 8 mum. At a distance of 10 mm, a maximum SPL of 73 dB was found at a frequency of 16.59 kHz.
Concurrent chemotherapy (carboplatin, paclitaxel, etoposide) and involved-field radiotherapy in limited stage small cell lung cancer: a Dutch multicenter phase II study (2006)

To improve the prognosis of limited stage small cell lung cancer (LS-SCLC) the addition of concurrent thoracic radiotherapy to a platinum-containing regimen is important. In the Netherlands, we initiated a multicenter, phase II study, of the combination of four cycles of carboplatin (AUC 5), paclitaxel (200 mg m(-2)) and etoposide (2 x 50 mg orally for 5 days) combined with 45 Gy (daily fractions of 1.8 Gy). The radiation was given to the involved field and concurrently with the second and third chemotherapy cycle. Patients with a partial or complete response received prophylactic cranial irradiation to a dose of 30 Gy. From January 1999 to December 2001, 37 of the 38 patients with LS-SCLC entered were eligible for toxicity analysis and response. Grade 3 and 4 haematological toxicity occurred in 57% (21/37) with febrile neutropenia in 24% (9/37). There were no treatment-related deaths or other grade 4 toxicity. Grade 3 toxicities were oesophagitis (27%), radiation pneumonitis (6%), anorexia (14%), nausea (16%), dyspnea (19%) and lethargy (22%). The objective response rate was 92% (95% confidence interval (CI) 80-98%) with a median survival time of 19.5 months (95% CI 12.8-29.2). The 1-, 2- and 5-year survival rate was 70, 47 and 27%, respectively. In field local recurrences occurred in six patients. Distant metastases were observed in 19 patients of which 13 in the brain. This study indicates that combination chemotherapy with concurrent involved-field radiation therapy is an effective treatment for LS-SCLC. Despite PCI, the brain remained the most important site of recurrence.
Determination of gibberellins in fermentation broth produced by <i>Fusarium verticilliodes</i> MTCC 156 by high‐performance liquid chromatography tandem mass spectrometry (2004)

A method for the detection of gibberellins produced by Fusarium verticilliodes is described using HPLCMS/MS (HPLC tandem MS). A Hypersil (5 microm) octadecylsilane column with methanol/water as eluent in the ratio 3:1 at a flow rate of 0.5 ml/min was used. In the HPLCMS, GA(3) (gibberellic acid; m / z 346.3) eluted at retention time tr=3.08 min, with the corresponding mass chromatogram having peaks at m / z 346.7 and 328.8 corresponding to the M+ and M+-H2O ions respectively. The ethyl acetate extract from the broth, subjected to HPLCMS analysis under similar conditions, showed a constituent with tr=2.13 min, the mass chromatogram of which exhibited peaks at m / z 348.9 and 331.9 corresponding to the MH+ and MH+-H2O ions respectively. Comparison of the MS and MS/MS results (direct infusion) of an authentic sample of GA3 and the ethyl acetate extract from the broth revealed the formation of reduced GA3 in the broth. The present study, utilizing HPLCMS/MS, describes an improved methodology for the unambiguous determination and estimation of gibberellins from fermentation broth.
Notizen: Structures, Energies, and Reactivities of Bridgehead Olefins (1977)

Force field calculations of a series of bridgehead olefins give nonplanar double bond deformation energies which are correlated with chemical stability (reactivity) properties. Minimum potential energies allow an interpretation of experimental relative yields of isomeric bridgehead olefins with the same carbon skeleton. Pyramidal distortions (outof-plane bending) at the sp 2-carbon atoms are often found to contribute more prominently to the non-planar double bond deformations than pure twisting. Qualitative rules proposed in the past as to reactivity, thermodynamic stability, and structure of bridgehead olefins do not always agree with the computational results.
Direct Bonding of Gallium Arsenide on Silicon (1999)

Direct bonding of gallium arsenide on silicon is studied. The technology is expected to enable the easy integration of gallium arsenide optoelectronic devices with silicon very-large-scale integrated circuits. The interface quality of n-GaAs/p-Si can be improved with a thermal annealing process. It is examined by the current-voltage characteristics of the n-GaAs/p-Si diode. The bonding strength was found to be sufficiently high and could “high enough to” withstand the subsequent grinding and polishing procedures of the bonded wafers.
The Contribution of Anulus Fibers to Torque Resistance (1996)

In lumbar motion segments without degeneration, anulus fibers restrict axial rotation more than the facets.