gebhart/patrepeval huggingface dataset:
Potentiation of the anaphylatoxins in vivo using an inhibitor of serum carboxypeptidase N (SCPN). I. Lethality and pathologic effects on pulmonary tissue. (1983)

Carboxypeptidase N (EC 3.4.12.7) (SCPN) is a plasma enzyme that efficiently inactivates the anaphylatoxins C3a and C4a and significantly reduces C5a spasmogenic activity by removing the C-terminal arginyl residue from each of these factors. The arginine analog DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (SCPN-INH) is a potent competitive inhibitor of SCPN with a Ki for this carboxypeptidase in serum of 2 x 10(-9) M. Therefore, we have used the SCPN inhibitor to potentiate biologic activity of the anaphylatoxins in vivo. Infusion via the carotid artery of about 40 mg of SCPN-INH into each of 8 adult guinea pigs inactivated the SCPN for at least 3 hours and caused no measurable toxic effects. When cobra venom factor (CVF) is infused into guinea pigs, it activates the alternative pathway of complement, thereby generating the anaphylatoxins C3a and C5a. Ordinarily, infusion of CVF is nonlethal, because the generated anaphylatoxins are rapidly converted to C3a des Arg and C5a des Arg by SCPN. However, CVF (200 micrograms) plus SCPN-INH delivered intravenously in 5 animals induced a lethal reaction in less than 5 minutes. The authors conclude that the lethal effect is due largely to the anaphylatoxins. Histologic sections of the lungs from treated animals show dramatic structural changes consistent with peripheral small airway constriction, bronchial constriction, and vasoconstriction of small muscular arteries. Also, cell aggregates are present in blood vessels. Other histologic changes include severe congestion, pulmonary edema, and an interstitial infiltrate of mononuclear cells. Large doses of chlorpheniramine prevent this lethal reaction. Lethality is apparently attributable to asphyxia and is dependent on the level of CVF administered: eg, 100 micrograms CVF was not lethal in 4 animals given SCPN inhibitor, although signs of respiratory distress were observed. On histologic examination of lungs from guinea pigs given CVF and SCPN-INH, the features are similar to those described when anaphylatoxins are instilled into guinea pig lungs. Intravenous application of purified C3a plus SCPN-INH also proved lethal in 3 of the 6 animals challenged. This is the first evidence that the C3a anaphylatoxin can elicit a lethal response.
Parents’ Growth in Childhood and the Birth Weight of Their Offspring (2004)

Our findings are consistent with the hypothesis that maternal growth during childhood influences offspring birth weight, independently of maternal birth weight, final attained height, or midgrandparental height. Because leg length is a sensitive marker of adverse nutritional and social exposures during childhood, these results suggest a key role for a mother's early environmental exposures as a determinant of her child's subsequent health.
<i>N</i>-(2-Methoxybenzyl)-9-(oxolan-2-yl)-9<i>H</i>-purin-6-amine (2013)

The title compound, C17H19N5O2, features an almost planar purine skeleton (r.m.s. deviation = 0.009 Å) substituted by a tetra-hydro-furan ring, which adopts an envelope conformation. The purine and benzene rings subtend a dihedral angle of 66.70 (3)°. In the crystal, pairs of N-H⋯N hydrogen bonds connect adjacent mol-ecules into inversion dimers. C-H⋯N, C-H⋯O, C-H⋯π and π-π inter-actions [pyrimidine ring centroid-centroid distance = 3.3909 (1) Å] connect the dimers into a three-dimensional architecture.
Benefit of interferon β-1a on MSFC progression in secondary progressive MS (2002)

IFNbeta-1a demonstrated benefit on MSFC progression, relapses, quality of life, and MRI activity in SPMS.
Hybrid applications over XML (2002)

We discuss the design of a quasi-statically typed language for XML in which data may be associated with different structures and different algebras in different scopes, whilst preserving identity. In declarative scopes, data are trees and may be queried with the full flexibility associated with XML query algebras. In procedural scopes, data have more conventional structures, such as records and sets, and can be manipulated with the constructs normally found in mainstream languages.For its original form of structural polymorphism, the language offers integrated support for the development of hybrid applications over XML, where data change form to reflect programming expectations and enable their enforcement.
p53 can repress transcription of cell cycle genes through a p21<sup>WAF1/CIP1</sup>-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements (2012)

The tumor suppressor p53 plays an important role in cell cycle arrest by downregulating transcription. Many genes repressed by p53 code for proteins with functions in G₂/M. A large portion of these genes is controlled by cell cycle-dependent elements (CDE) and cell cycle genes homology regions (CHR) in their promoters. Cyclin B2 is an example of such a gene, with a function at the transition from G₂ to mitosis. We find that p53-dependent downregulation of cyclin B2 promoter activity is dependent on an intact CHR element. In the presence of high levels of p53 or p21WAF1/CIP1, protein binding to the CHR switches from MMB to DREAM complex by shifting MuvB core-associated proteins from B-Myb to E2F4/DP1/p130. The results suggest a model for p53-dependent transcriptional repression by which p53 directly activates p21WAF1/CIP1. The inhibitor then prevents further phosphorylation of p130 by cyclin-dependent kinases. The presence of hypophosphorylated pocket proteins shifts the equilibrium for complex formation from MMB to DREAM. In the case of promoters that do not hold CDE or E2F elements, binding of DREAM and MMB solely relies on a CHR site. Thus, p53 can repress target genes indirectly through CHR elements.
Sistemas Sensores em Desenvolvimento no Grupo de Fotônica do DES-UFPE (2011)

Neste artigo sao descritos alguns dos desenvolvimentos realizados nos ultimos anos na area de Sensores do Grupo de Fotonica do DES-UFPE. Sistemas completos para aplicacoes cientificas e industriais tem sido elaborados com base em uma metodologia que abrange desde o projeto da cabeca sensora e do circuito de processamento eletronico dos sinais — passando pelo dimensionamento e implantacao do sistema de comunicacao mais adequado para a transmissao desses sinais — ate o desenvolvimento do aplicativo de aquisicao e gerenciamento dos dados para o usuario final. Algumas aplicacoes sao brevemente discutidas, e tres sistemas, um com potencial de aplicacao no setor de petroleo e gas e dois outros desenvolvidos para o setor eletrico sao descritos de forma mais detalhada.
Rizatriptan Combined with Rofecoxib Vs. Rizatriptan for the Acute Treatment of Migraine: an Open Label Pilot Study (2002)

Rizatriptan is an effective and fast acting drug for the acute treatment of migraine. As with any other acute treatment for migraine, headache recurrence may occur in up to one-third of responders. Combination with non-steroidal anti-inflammatory drugs (NSAIDs) seems to reduce the incidence of headache recurrence in clinical practice. Rofecoxib is a member of a new class of NSAIDs, which selectively inhibits the COX-2 enzyme and therefore is associated with a lower risk of gastrointestinal side-effects; the drug has a long plasma half-life (17 h). This open label study compared rizatriptan with rizatriptan plus rofecoxib in the acute treatment of migraine. Fifty-six triptan naive patients from a tertiary centre (37 women and 19 men, ages 16-55 years, mean 35 years) with International Headache Society migraine were randomized into two groups. They were instructed to treat three consecutive moderate or severe attacks with either 10 mg rizatriptan (group 1: 18 women and 10 men) or with 10 mg rizatriptan plus 25 mg rofecoxib (group 2: 19 women and 9 men). The presence of headache and nausea at 1, 2 and 4 h, and of side-effects, use of rescue medication and recurrence were compared. Fifty-four patients completed the study. Group 1 treated 76 attacks and group 2 treated 81 attacks. Absence of headache at 1 h was seen in 19 attacks (25%) in group 1 and in 34 attacks (42%) in group 2 (P=0.082); at 2 h absence of headache was seen in 60% of group 1 attacks and in 76% of group 2 attacks (P=0.115). At 4 h, 75% of group 1 attacks and 88% of group 2 attacks were pain free (P=0.122). With regard to nausea, of those who had nausea at baseline, 31% and 49% of attacks in groups 1 and 2, respectively, were nausea free at 1 h (P=0.091), 75% and 79% at 2 h (P=0.736) and 82% and 91% (P=0.479) at 4 h. Recurrence, based on all attacks of those patients who achieved pain free at 4 h, was observed in 53% of group 1 and 20% of group 2 attacks (P<0.001). Sustained pain-free rates (for the 4-h time point) were 45.6% of group 1 and 78.9% of group 2 attacks. There were no significant differences with regard to rescue medication consumption after 4 h and side-effects in both groups. There was a non-significant trend for the combination group to have a higher response rate. The group treated with rizatriptan and rofecoxib had a lower recurrence rate than the group treated with rizatriptan. This study demonstrated that combining a fast acting triptan such as rizatriptan with rofecoxib reduced headache recurrence rates, was well tolerated and may be more effective than the use of rizatriptan alone. Double-blind, placebo-controlled studies are necessary to confirm these observations.
A cis-acting element in the BCL-2 gene controls expression through translational mechanisms. (1996)

The bcl-2 gene becomes activated in many types of human cancers and contributes to neoplastic cell expansion, as well as to resistance to radiation and chemotherapy, by blocking programmed cell death or apoptosis. The expression of this proto-oncogene is regulated at both the transcriptional and post-transcriptional levels. DNA sequence comparisons of human, mouse, rat and chicken bcl-2 cDNAs revealed the presence of an open reading frame (ORF) [correction of (OFR)] located upstream of the normal coding region. Because upstream ORFs (uORFs) have been associated with translational repression, we analysed the functional significance of the 11 amino-acid uORF in the human BCL-2 gene (-119 to -84 bp). Deletion of this uORF from chloramphenicol acetyltransferase (CAT) reporter gene constructs that contained the bcl-2 promoter and entire 5'-untranslated region (5'-UTR), as well as introduction of an A-->T mutation at position -119 bp that destroyed the AUG-initiation codon, significantly increased CAT activity in HeLa, CEM, and other cell lines, without producing a corresponding elevation in CAT mRNA levels. Positioning this uORF, together with its accompanying Kozak sequences, between a heterologous promoter from SV40 and a CAT reporter gene resulted in marked inhibition of CAT protein production without a decrease in CAT mRNA. Mutation of the start codon (ATG-->TTG) of this uORF completely abolished its inhibitory activity, consistent with a translational mechanism. Taken together, these findings suggest that the uORF located within the 5'UTR of the bcl-2 gene is necessary and sufficient for translational regulation of bcl-2 gene expression.
Utilizing Radio-Frequency Interconnect for a Many-DIMM DRAM System (2012)

The demand for capacity and off-chip bandwidth to dynamic random-access memory (DRAM) will continue to grow as we integrate more cores onto a die. However, as the data rate of DRAM has increased, the number of dual in-line memory modules (DIMMs) supported on a multi-drop bus has decreased. Therefore, traditional memory systems are not sufficient to meet both these demands. We propose the DIMM tree architecture for better scalability by connecting the DIMMs as a tree. The DIMM tree architecture is able to grow the number of DIMMs exponentially with each level of latency in the tree. We also propose application of multiband radio-frequency interconnect (MRF-I) to the DIMM tree architecture for even greater scalability and higher throughput. The DIMM tree architecture without MRF-I was able to scale up to 64 DIMMs with only an 8% degradation in throughput over an ideal system. The DIMM tree architecture with MRF-I was able to increase throughput by 68% (up to 200%) on a 64-DIMM system over a 4-DIMM system. Finally, we propose the partitioned DIMM tree, which allows the scaling of a main memory system to a many-DIMM memory system while still maintaining high throughput. The partitioned DIMM tree is able to improve throughput by an average of 19% up to 35% over the DIMM tree with 256 DIMMs on a single channel.
A novel association of DQ alpha and DQ beta genes in the DRw10 haplotype. Determination of a DQw1 specificity by the DQ beta-chain. (1989)

The association of the class II genes of the DRw10 haplotype from a cell line, NASC, initiated from a member of a well characterized family, was analyzed by sequencing cDNA clones corresponding to DR beta I, DQ alpha, and DQ beta genes. An identical haplotype was also identified in the Raji cell line. In addition to typing as DRw10 and DQw1 with HLA typing sera both, the NASC and Raji cell lines were shown to react strongly with the monoclonal antibodies 109d6 (specific for DRw10 beta 1 and DRw53 beta 2 gene products) and Genox 3.5.3 (specific for DQw1) and exhibited the restriction fragment length polymorphism indicative of a DRw10, DQw1 haplotype. The DR beta 1 gene corresponding to the DRw10 specificity was found to have a first domain sequence different from all other DR beta I genes. Sequence analysis of the 3'-untranslated region of this DR beta-chain gene showed a significant divergence from the 3' untranslated region of the DRw53 family of haplotypes and a lesser divergence from that of the DRw52 and DR1/DR2 families. The sequence of the DQ beta genes corresponding to the DQw1 specificity in the DRw10 haplotype was found to be identical to the DQ beta gene from a DR1, DQw1 haplotype. Surprisingly, however, the DQ alpha gene did not resemble other DQw1-like DQ alpha genes, but was identical in sequence to the DQ alpha gene found in DR4 haplotypes. The novel association of DQ alpha and DQ beta genes in the DRw10 haplotype revealed in these studies may result from a double recombinational event. More consequentially, these studies strongly suggest that the DQw1 specificity recognized by Genox 3.5.3 is determined by the DQ beta chain and is not affected by the DQ alpha-chain.
Speaker-Independent HMM-based Speech Synthesis System: HTS-2007 System for the Blizzard Challenge 2007 (2007)

This paper describes an HMM-based speech synthesis system developed by the HTS working group for the Blizzard Challenge 2007. To further explore the potential of HMM-based speech synthesis, we incorporate new features in our conventional system which underpin a speaker-independent approach: speaker adaptation techniques; adaptive training for HSMMs; and full covariance modeling using the CSMAPLR transforms.
Solubilization of Therapeutic Agents in Micellar Nanomedicines (2013)

We use atomistic molecular dynamics simulations to reveal the binding mechanisms of therapeutic agents in PEG-ylated micellar nanocarriers (SSM). In our experiments, SSM in buffer solutions can solubilize either ≈11 small bexarotene molecules or ≈6 (2 in low ionic strength buffer) human vasoactive intestinal peptide (VIP) molecules. Free energy calculations reveal that molecules of the poorly water-soluble drug bexarotene can reside at the micellar ionic interface of the PEG corona, with their polar ends pointing out. Alternatively, they can reside in the alkane core center, where several bexarotene molecules can self-stabilize by forming a cluster held together by a network of hydrogen bonds. We also show that highly charged molecules, such as VIP, can be stabilized at the SSM ionic interface by Coulombic coupling between their positively charged residues and the negatively charged phosphate headgroups of the lipids. The obtained results illustrate that atomistic simulations can reveal drug solubilization character in nanocarriers and be used in efficient optimization of novel nanomedicines.
Magneto-resistive elements-an alternative to floating gate technology (2003)

Magnetoresistive elements have previously been fabricated and tested for storage of data. Due to the nonvolatile property of these elements they can be used to replace floating gate storage cells. A programmable logic array (PLA) using on-chip magnetoresistive elements is simulated and its layout shown to illustrate the applicability of these elements. The die size for the 6*16*4 PLA is 2000 mu m*2000 mu m with 2- mu m technology. The PLA has a delay of 20 ns during normal operation. Programming time is 20 ns/cross point, and power up time is 1 mu s.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Neuroprotective effects of GYKI 52466 on experimental spinal cord injury in rats (2003)

The findings in this rat model suggest that GYKI 52466 may provide significant therapeutic protection from secondary damage after acute SCI. This agent may be a viable alternative treatment for SCI.
Active Damping of Torsional Drillstring Vibrations With a Hydraulic Top Drive (1995)

Summary This paper describes the development and field testing of a new active-damping system to eliminate "stick/slip" torsional drillstring vibrations. The system controls the energy flow through a hydraulic top drive and makes the top drive react as a tuned vibration damper. The control algorithm, outlined in the paper, was implemented in software in the electronic control system for the pump unit of the top drive. Dedicated workshop testing allowed for a rapid installation at the rigsite. The system was field tested in a deep exploration well in the Barents Sea and contributed to excellent coring performance by eliminating torsional vibrations while coring hard limestone.
Selective excitation of single-mode acoustic waves by phase velocity scanning of a laser beam (1991)

A novel method for selective generation of single-mode acoustic waves in multimode media has been developed using a laser beam scanned at the phase velocity of a specified mode. In dispersive media, the acoustic frequency can be varied by changing the scanning velocity. The number of carriers in the generated wave packet is proportional to the difference between the phase and the group velocities. These features were experimentally verified in the fundamental symmetric and asymmetric Lamb waves on an aluminum plate generated by a long-pulse Nd:YAG laser. Applications to anisotropy and thickness measurements are discussed.
Dynamic Weather Routes: A Weather Avoidance Concept for Trajectory-Based Operations (2011)

The integration of convective weather modeling with trajectory automation for conflict detection, trial planning, direct routing, and auto resolution has uncovered a concept that could help controllers, dispatchers, and pilots identify improved weather routes that result in significant savings in flying time and fuel burn. Trajectory automation continuously and automatically monitors aircraft in flight to find those that could potentially benefit from improved weather reroutes. Controllers, dispatchers, and pilots then evaluate reroute options to assess their suitability given current weather and traffic. In today's operations aircraft fly convective weather avoidance routes that were implemented often hours before aircraft approach the weather and automation does not exist to automatically monitor traffic to find improved weather routes that open up due to changing weather conditions. The automation concept runs in real-time and employs two keysteps. First, a direct routing algorithm automatically identifies flights with large dog legs in their routes and therefore potentially large savings in flying time. These are common - and usually necessary - during convective weather operations and analysis of Fort Worth Center traffic shows many aircraft with short cuts that indicate savings on the order of 10 flying minutes. The second and most critical step is to apply trajectory automation with weather modeling to determine what savings could be achieved by modifying the direct route such that it avoids weather and traffic and is acceptable to controllers and flight crews. Initial analysis of Fort Worth Center traffic suggests a savings of roughly 50% of the direct route savings could be achievable.The core concept is to apply trajectory automation with convective weather modeling in real time to identify a reroute that is free of weather and traffic conflicts and indicates enough time and fuel savings to be considered. The concept is interoperable with today's integrated FMS/datalink. Auxiliary(lat/long) waypoints define a minimum delay reroute between current position and a downstream capture fix beyond the weather. These auxiliary waypoints can be uplinked to equipped aircraft and auto-loaded into the FMS. Alternatively, for unequipped aircraft, auxiliary waypoints can be replaced by nearby named fixes, but this could reduce potential savings. The presentation includes an overview of the automation approach and focuses on several cases in terms of potential savings, reroute complexity, best auxiliary waypoint solution vs. named fix solution, and other metrics.
New Frontiers of Delivery Services Using Drones: A Prototype System Exploiting a Quadcopter for Autonomous Drug Shipments (2015)

Drone-based delivery of goods could become a reality in the near future, as witnessed by the increasing successful experiences in both research and commercial fields. In this paper, a prototype system exploiting a do it yourself quad copter drone for delivering products is proposed. On the one hand, the hardware choices made in order to limit risks arising from autonomous delivery are presented. On the other hand, a framework for orders placement and shipment is shown. The advantages of a system like the one described in this paper are mainly related to an increased delivery speed, especially in urban contexts with traffic, to the possibility to make deliveries in areas usually difficult to be reached, and to the drone's ability to autonomously carry out consignments. A practical use case, in which the proposed system is used for delivering drugs (an application in which the need to quickly receive the good might be particularly important) is shown. Nevertheless, the proposed prototype could be employed in other contexts, such as take-away deliveries, product shipments, registered mail consignments, etc.
Anti‐high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats (2007)

The high mobility group box-1 (HMGB1), originally identified as an architectural nuclear protein, exhibits an inflammatory cytokine-like activity in the extracellular space. Here we show that treatment with neutralizing anti-HMGB1 monoclonal antibody (mAb; 200 microg, twice) remarkably ameliorated brain infarction induced by 2-h occlusion of the middle cerebral artery in rats, even when the mAb was administered after the start of reperfusion. Consistent with the 90% reduction in infarct size, the accompanying neurological deficits in locomotor function were significantly improved. Anti-HMGB1 mAb inhibited the increased permeability of the blood-brain barrier, the activation of microglia, the expression of TNF-alpha and iNOS, and suppressed the activity of MMP-9, whereas it had little effect on blood flow. Intracerebroventricular injection of HMGB1 increased the severity of infarction. Immunohistochemical study revealed that HMGB1 immunoreactivity in the cell nuclei decreased or disappeared in the affected areas, suggesting the release of HMGB1 into the extracellular space. These results indicate that HMGB1 plays a critical role in the development of brain infarction through the amplification of plural inflammatory responses in the ischemic region and could be an outstandingly suitable target for the treatment. Intravenous injection of neutralizing anti-HMGB1 mAb provides a novel therapeutic strategy for ischemic stroke.