gebhart/patrepeval huggingface dataset:
The Action of Oxidizing Agents on Salts of Nitroalkanes. I. Oxidative Dimerization<sup>1,2,3</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Action of Oxidizing Agents on Salts of Nitroalkanes. I. Oxidative Dimerization1,2,3Harold Shechter and Ralph B. KaplanCite this: J. Am. Chem. Soc. 1953, 75, 16, 3980–3983Publication Date (Print):August 1, 1953Publication History Published online1 May 2002Published inissue 1 August 1953https://pubs.acs.org/doi/10.1021/ja01112a031https://doi.org/10.1021/ja01112a031research-articleACS PublicationsRequest reuse permissionsArticle Views259Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
RENAL MEDULLARY CARCINOMA AND <i>ABL</i> GENE AMPLIFICATION (2005)

RMC is typically seen in young individuals with the sickle cell trait. It is diagnosed when metastatic, is not responsive to systemic therapy and rapidly causes death. Because cure appears possible with early diagnosis, increased awareness of the disease could make an impact. The use of thalidomide or newer anti-angiogenesis agents should be considered for advanced disease. The role of ABL amplification with respect to etiology and as a therapeutic target should be investigated further.
Piezoresistive accelerometers for MCM-package - Part II:The packaging (2005)

This paper is the second part of a twofold work related to the full integration of piezoresistive accelerometers in a multichip modules-deposited (MCM-D) type with flip-chip interconnection package. This part is fully devoted to the packaging of an accelerometer with movable parts in an MCM so a description of the package fabrication is given. The accelerometer was designed taking into account its final package and, therefore, some modifications to the standard piezoresistive accelerometer were done. In particular, a sealing ring was defined around the movable parts of the sensor in order to protect them from the underfill used during the final packaging process. This underfill is being studied at the moment so the tests performed have been without taking into account its effects. After the manufacturing step the MCM packaged accelerometers are attached to a PLCC44 substrate and characterized. The results show an improvement on the sensors performance when using the MCM solution in comparison to the accelerometers packaged in standard TO-8. The results show that the influence of the packaging technique on the final stress of the sensors is negligible. They also show an extra damping due to the confined air volume around the swinging proof mass of the accelerometers. The quality factor of the TO-8 packaged accelerometers is of 12 whereas for the MCM packaged devices is of 1, 2. This low-quality factor is of great interest for applications where the devices can suffer large acceleration changes. Finally, the results are in good agreement with the FEM simulations previously done and they demonstrate the viability of this technology.
Exploitation by Informed Exploration between Isolated Operatives for information-theoretic data harvesting (2015)

We consider the problem of ferrying data between nodes of a sparsely distributed sensing network of Unattended Ground Sensors (UGS) with endurance-constrained Unmanned Aerial Systems (UAS). The sensing domain wherein the sparsely distributed UGS network is deployed is assumed to be highly nonstationary (time-varying) and noisy. This makes the data-ferrying problem very complicated as the expected value-of-information at a sensing location can rapidly change. To address this issue, we present a new data ferrying algorithm termed Exploitation by Informed Exploration between Isolated Operatives (EIEIO), and show that with several reasonable assumptions and a model on the predicted accumulation of value-of-information, the problem can be simplified to a mathematical linear program. To solve the linear program, the UAS learns to anticipate regions in the sensing domain that have the highest degree of change. The degree of change, is learned using a novel implementation of a Cox Process called the Cox-Gaussian Process (CGP). Our approach does not require a priori knowledge of the sensing domain model to arrive at an optimal UAS allocation strategy.
A capacity investigation on UTRA-TDD utilising underused UTRA-FDD uplink resources (1999)

This paper presents an analytical approach to calculate the capacity that a UMTS terrestrial radio access-TDD (UTRA-TDD) pico cell can exploit from underused uplink radio resources of a UTRA-FDD macro cellular overlay. Also, the impact on the UTRA-FDD uplink capacity is evaluated. Underused FDD spectrum is a consequence of a growing demand for an asymmetrical use of communication channels. This study is carried out under the assumption of a spatially uniform user distribution. It was found that under the assumption made, the TDD underlay can be used to increase the flexibility of the UMTS air interface. However, the advantages of the underlay are dependent on the BS separation and the severity of lognormal shadowing. The optimal BS separation was found to be between 200 m and 300 m. Methods are proposed to overcome the revealed constraints.
<i>Actinobacillus actinomycetemcomitans</i> in human periodontal disease (1985)

Recent evidence implicates Actinobacillus actinomycetemcomitans in the etiology of localized juvenile periodontitis. This paper reviews the morphological, biochemical and serological charcteristics of A. actinomycetemcomitans, evidence incriminating it as a periodontopathogen, its importance in human nonoral infections, and virulence factors which may be involved in the pathogenesis of A. actinomycetemcomitans infections. A. actinomycetemcomitans is a non-motile, gram-negative, capnophilic, fermentative coccobacillus which closely resembles several Haemophilus species but which does not require X or V growth factors. The organism has been categorized into 10 biotypes based on the variable fermentation of dextrin, maltose, mannitol, and xylose and into 3 serotypes on the basis of heat stable, cell surface antigens. A. actinomycetemcomitans' primary human ecologic niche is the oral cavity. It is found in dental plaque, in periodontal pockets, and buccal mucosa in up to 36% of the normal population. The organism can apparently seed from these sites to cause severe infections throughout the human body such as brain abscesses and endocarditis. There is a large body of evidence which implicates A. actinomycetemcomitans as an important micro-organism in the etiology of localized juvenile periodontitis including: (1) an increased prevalence of the organism in almost all localized juvenile periodontitis patients and their families compared to other patient groups; (2) the observation that localized juvenile periodontitis patients exhibit elevated antibody levels to A. actinomycetemcomitans in serum, saliva and gingival crevicular fluid; (3) the finding that localized juvenile periodontitis can be successfully treated by eliminating A. actinomycetemcomitans from periodontal pockets; (4) histopathologic investigations showing that A. actinomycetemcomitans invades the gingival connective tissue in localized juvenile periodontitis lesions; (5) the demonstration of several pathogenic products from A. actinomycetemcomitans including factors which may: (a) facilitate its adherence to mucosal surfaces such as capsular polysaccharides; (b) inhibit host defense mechanisms including leukotoxin, a polymorphonuclear leukocyte chemotaxis inhibiting factor, and a lymphocyte suppressing factor (c) cause tissue destruction such as lipopolysaccharide endotoxin, a bone resorption-inducing toxin, acid and alkaline phosphatases, collagenase, a fibroblast inhibiting factor and an epitheliotoxin.(ABSTRACT TRUNCATED AT 400 WORDS)
Ultrafast all optical switching in two wavelength amplifying nonlinear optical loop mirror (1992)

An ultrafast optical switch is described based on optical pulse switching in a nonlinear loop mirror incorporating an erbium doped fibre amplifier. Semiconductor laser diodes are used throughout, emphasising the practical applicability of this device. A 10 bit/s pulse stream comprising 20 ps pulses is modulated by a −7.4dBm, 10 Gbit/s NRZ optical data stream.
Selective Precipitation and Removal of Lipids from Cheese Whey Using Chitosan (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective Precipitation and Removal of Lipids from Cheese Whey Using ChitosanDer-Chyan Hwang and Srinivasan DamodaranCite this: J. Agric. Food Chem. 1995, 43, 1, 33–37Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/jf00049a008https://doi.org/10.1021/jf00049a008research-articleACS PublicationsRequest reuse permissionsArticle Views789Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Holey optical fiber with circularly distributed holes analyzed by the radial effective-index method (2003)

We analyze a holey fiber that consists of a circular distribution of air holes by the radial effective-index method. By this method, we show that the holey fiber is a leaky structure and its extended single-mode operation is governed by the differential leakage loss between the first two modes of the fiber. The effects of the hole size and the hole separation on the leakage losses of the first two modes are calculated. The leakage loss of the fundamental mode of the fiber is found to be comparable to that of a conventional holey fiber that has a hexagonal distribution of air holes.
Novel urinary exosomal biomarkers of acute T cell-mediated rejection in kidney transplant recipients: A cross-sectional study (2018)

Tetraspanin-1 and hemopexin were detected in KTR urine and could act as potential diagnostic proteins for TCMR.
Long-Chain Glycerol Diether and Polyol Dialkyl Glycerol Triether Lipids of <i>Sulfolobus acidocaldarius</i> (1974)

Cells of Sulfolobus acidocaldarius contain about 2.5% total lipid on a dry-weight basis. Total lipid was found to contain 10.5% neutral lipid, 67.6% glycolipid, and 21.7% polar lipid. The lipids contained C(40)H(80) isopranol glycerol diethers. Almost no fatty acids were present. The glycolipids were composed of about equal amounts of the glycerol diether analogue of glucosyl galactosyl diglyceride and a glucosyl polyol glycerol diether. The latter compound contained an unidentified polyol attached by an ether bond to the glycerol diether. The polar lipids contained a small amount of sulfolipid, which appeared to be the monosulfate derivative of glucosyl polyol glycerol diether. About 40% of the lipid phosphorus was found in the diether analogue of phosphatidyl inositol. The remaining lipid phosphorus was accounted for by approximately equal amounts of two inositol monophosphate-containing phosphoglycolipids, inositolphosphoryl glucosyl galactosyl glycerol diether and inositolphosphoryl glucosyl polyol glycerol diether.
Shielded silicon gate complementary MOS integrated circuit (1972)

An electrostatic shield for complementary MOS integrated circuits was developed to minimize the adverse effects of stray electric fields created by the potentials in the metal interconnections. The process is compatible with silicon gate technology. n-doped polycrystalline silicon was used for all the gates and the shield. The effectiveness of the shield was demonstrated by constructing a special field plate over certain transistors. The threshold voltages obtained on a oriented silicon substrate ranged from 1.5 to 3 V for either channel. Integrated inverters performed satisfactorily from 3 to 15 V, limited at the low end by the threshold voltages and at the high end by the drain breakdown voltage of the n-channel transistors. The stability of the new structure with an n-doped silicon gate as measured by the shift in <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C-V</tex> curve under 200°C ± 20 V temperature-bias conditions was better than conventional aluminum gate or p-doped silicon gate devices, presumably due to the doping of gate oxide with phosphorous. The advantages of the new structure are: avoidance of field inversion, elimination of guard rings, and thinner and more stable oxides.
Behavior of Colloidal Nanosilica in an Ultrahigh Performance Concrete Environment Using Dynamic Light Scattering (2019)

The dispersion quality of nanosilica (NS) is an essential parameter to influence and control the material characteristics of nanosilica-enhanced concrete. In this research, the dispersion quality of colloidal nanosilica in simulated concrete environments was investigated using dynamic light scattering. A concrete environment was simulated by creating a synthetic pore solution that mimicked the ionic concentration and pH value of ultrahigh-performance concrete in the fluid state. Four colloidal nanosilica samples were used, ranging in particle sizes from 5 to 75 nm, with differing solid contents and stabilizing ions. It was found that the sodium stabilized 20 nm NS sol remains dispersed at a solid concentration of 2 wt % through a variety of pH values with the inclusion of potassium ions. Calcium ions are a major contributor to the agglomeration of NS sols and only small concentrations of calcium ions can drastically affect the dispersion quality.
Exendin-4 Improves Nonalcoholic Fatty Liver Disease by Regulating Glucose Transporter 4 Expression in ob/ob Mice (2014)

Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor (GLP-1R) agonist, has been known to reverse hepatic steatosis in ob/ob mice. Although many studies have evaluated molecular targets of Ex-4, its mechanism of action on hepatic steatosis and fibrosis has not fully been determined. In the liver, glucose transporter 4 (GLUT4) is mainly expressed in hepatocytes, endothelial cells and hepatic stellate cells (HSCs). In the present study, the effects of Ex-4 on GLUT4 expression were determined in the liver of ob/ob mice. Ob/ob mice were treated with Ex-4 for 10 weeks. Serum metabolic parameters, hepatic triglyceride levels, and liver tissues were evaluated for hepatic steatosis. The weights of the whole body and liver in ob/ob mice were reduced by long-term Ex-4 treatment. Serum metabolic parameters, hepatic steatosis, and hepatic fibrosis in ob/ob mice were reduced by Ex-4. Particularly, Ex-4 improved hepatic steatosis by enhancing GLUT4 via GLP-1R activation in ob/ob mice. Ex-4 treatment also inhibited hepatic fibrosis by decreasing expression of connective tissue growth factor in HSCs of ob/ob mice. Our data suggest that GLP-1 agonists exert a protective effect on hepatic steatosis and fibrosis in obesity and type 2 diabetes.
Activation of local aldosterone system within podocytes is involved in apoptosis under diabetic conditions (2009)

Previous studies have shown that mineralocorticoid receptor (MCR) blocker reduces proteinuria in diabetic nephropathy (DN), but the role of aldosterone in podocyte injury has never been explored in...
Human platelet‐rich plasma stimulates migration and chondrogenic differentiation of human subchondral progenitor cells (2011)

In cartilage repair, platelet-rich plasma (PRP) is used in one-step approaches utilizing microfracture and matrix-induced chondrogenesis procedures, bone marrow-derived cell transplantation, or intra-articular injection. The aim of our study was to evaluate the effect of human PRP on the migration and chondrogenic differentiation of human subchondral progenitors. Human progenitors were derived from subchondral cortico-spongious bone (CSP), were analyzed for their migration capacity upon PRP treatment in 96-well chemotaxis assays and cultured in high-density pellet cultures under serum-free conditions in the presence of 5% PRP. Chemotaxis assays showed that 0.1-100% PRP significantly (p < 0.05) stimulate the migration of CSP compared to untreated controls. Histological staining of proteoglycan and immuno-staining of type II collagen indicated that progenitors stimulated with PRP show significantly increased cartilage matrix formation compared to untreated progenitors. Real-time gene expression analysis of typical chondrocyte marker genes as well as osteogenic and adipogenic markers like osteocalcin and fatty acid binding protein showed that PRP induces the chondrogenic differentiation sequence of human progenitors in high-density pellet cultures, while osteogenic or adipogenic differentiation was not evident. These results suggest that human PRP may enhance the migration and stimulate the chondrogenic differentiation of human subchondral progenitor cells known from microfracture.
Reconfigurable bandpass filter with a three-to-one switchable passband width (2003)

A reconfigurable bandpass filter is described that aims to preserve the optimal performance of a broad-band system under changing signal conditions. It does so by allowing the passband width of the system's receiver to adapt. The filter can be switched between two discrete states with widely differing bandwidths of 500 and 1500 MHz, respectively, while keeping the passband responses centered at 10 GHz. The physical implementation comprises a hybrid-integrated microstrip circuit on a 0.010-in-thick quartz substrate. The circuit employs commercial beam-lead p-i-n diodes to switch fixed-valued reactance elements. Despite the presence of semiconductor switching devices, the filter behaves very linearly, exhibiting measured passband third-order output-referenced intercept points that exceed 46 dBm in both switched states.
Efficient design of meganucleases using a machine learning approach (2014)

This new method shows competitive performance compared with state-of-the-art in silico physical models, with up to a fourfold increase in terms of the design success rate. Compared to experimental high-throughput screening methods, it reduces the number of screening experiments needed by a factor of more than 100 without affecting final performance.
Milk fat globule–EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium (2007)

Milk fat globule-EGF factor 8 (MFG-E8)/lactadherin participates in several cell surface-mediated regulatory events. Although its mRNA is present in the gut, the physiological roles of MFG-E8 in the intestinal mucosa have not been explored. Here we show that MFG-E8 was expressed in intestinal lamina propria macrophages from mice. Using a wound-healing assay, MFG-E8 was shown to promote the migration of intestinal epithelial cells through a PKCepsilon-dependent mechanism. MFG-E8 bound to phosphatidylserine and triggered reorientation of the actin cytoskeleton in intestinal epithelial cells at the wound edge. Depleting MFG-E8 in mice by administration of anti-MFG-E8 antibody or targeted deletion of the MFG-E8 gene resulted in a slowing of enterocyte migration along the crypt-villus axis and focal mucosal injury. Moreover, in septic mice, intestinal MFG-E8 expression was downregulated, which correlated with intestinal injury, interrupted enterocyte migration, and impaired restitution. Treatment with recombinant MFG-E8 restored enterocyte migration, whereas deletion of MFG-E8 impeded mucosal healing in mice with sepsis. These results suggest that a decrease in intestinal MFG-E8 impairs intestinal mucosal repair in sepsis. Together, our data indicate that MFG-E8 plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing and suggest that recombinant MFG-E8 may be beneficial for the treatment of bowel injuries.
Experimental and theoretical investigations of laser-induced crystallization and amorphization in phase-change optical recording media (1997)

We describe the numerical procedure for calculating three-dimensional profiles of temperature in a multilayer stack illuminated by a laser beam, and model the crystallization and amorphization kinetics for phase-change rewritable media. Experimental methods have been used to determine indirectly the probabilities of nucleation and growth for Ge2Sb2Te5 alloy. Some of the fundamental behaviors of phase-change erasable media, such as the crystallization of as-deposited amorphous phase, amorphization of supercooled liquid, and recrystallization of quenched amorphous phase, have been illustrated based on our three-dimensional temperature calculations and the model kinetics. The calculated transient reflectance behavior of as-deposited Ge2Sb2Te5 amorphous films in a single layer and in a quadrilayer stack, as well as the erasure behavior of Ge2Sb2Te5 alloy in a quadrilayer disk are in good agreement with experimental observations.
Time-saving formats for patient care planning in outpatient surgery units. (1991)

Due to the frequent patient turnover and the fast pace of an outpatient surgery unit, time is limited for developing an individual plan of care. Other factors making this task more complex are related to brief nursing observations and unclear patient expectations. Care plans are now mandated in the outpatient areas at Central Baptist Hospital in Lexington, KY. The plans need to be realistic, comprehensive, and timesaving, yet generic. A checklist format, which is described in this article, was the solution.
Scattering Angle Resolved Optical Coherence Tomography Detects Early Changes in 3xTg Alzheimer's Disease Mouse Model (2020)

Clinical OCT systems may be modified to record SAR-OCT images for non-invasive retinal diagnostic imaging of patients with neurodegenerative diseases such as AD.
Pitfalls in thermal emission studies (1963)

Pitfalls in thermal emission studies - terminology, experimental procedure, and physical standards