gebhart/patrepeval huggingface dataset:
Secure Association Rule Mining on Vertically Partitioned Data Using Private-Set Intersection (2020)

Data mining entails the discovery of unexpected but reusable knowledge from large unorganized datasets. Among the many available data-mining algorithms, association rule mining (ARM) is very common. It was developed to aggregate all data into one site and subsequently mine them. In recent years, organizations in different fields have been required to collaborate to create new value. However, data mining among and within organizations has raised privacy and confidentiality concerns. In our scheme, parties cannot share anything other than the number of records, including the candidate itemset. This study focuses on the private-set intersection instead of the scalar product and shows that this intersection enables organizations to execute ARM on vertically partitioned data, allowing flexible information sharing while preserving privacy without increasing communication and computation costs. Furthermore, we focus on the fact that the number of protocol rounds among parties can be reduced and present three use cases in which the proposed scheme works more effectively than the existing schemes.
Detection of Rearrangements of the BCL2 Major Breakpoint Region in Follicular Lymphomas Correlation of Polymerase Chain Reaction Results With Southern Blot Analysis (1992)

The translocation t(14;18)(q32;q21) occurs in 70% of follicular lymphomas and places the BCL2 proto-oncogene, normally located at 18q21, under the control of the immunoglobulin heavy chain (IgH) gene at 14q32. Its detection by the polymerase chain reaction (PCR), made possible by the close clustering of most of the BCL2 breakpoints in the major breakpoint region (MBR) of the gene, has numerous clinical applications. Since the PCR covers shorter lengths of DNA than Southern blotting, PCR-based tests may be more susceptible to microheterogeneity in breakpoint location. There have been no published studies of the impact of breakpoint microheterogeneity on the detection rate of this translocation by PCR. We studied 30 follicular lymphomas with the t(14;18), in which a BCL2 MBR rearrangement had previously been demonstrated and mapped by conventional Southern blotting, by PCR with the commonly used IgH and BCL2 MBR primers. Twenty-five cases (83%) had a junction fragment demonstrable by PCR. All three cases in which the MBR rearrangement mapped outside of the 4.3-kb HindIII fragment containing the MBR, as determined by Southern blotting, were negative by PCR. In addition, two cases with rearrangements within the HindIII fragment were also negative. All negative results were repeated at least once and were confirmed to be true negatives by actin PCR. Our results suggest that negative PCR results in this setting are attributable to small variations in BCL2 MBR breakpoint location and cannot be interpreted without the corresponding conventional Southern blotting data. With this caveat in mind, PCR analysis for the t(14;18) remains an extremely useful technique, especially in the follow-up and monitoring for minimal residual disease in previously characterized cases of follicular lymphoma.
Hybrid Density Functional Theory (DFT) Study on Electronic States of Halogen-Substituted Organic–Inorganic Hybrid Compounds: Al-NTCDA (2005)

Hybrid density functional theory (DFT) calculations have been carried out for high-performance molecular devices, complexes of naphthalene tetracarboxylic dianhydride (NTCDA) and halogen-substituted NTCDA with aluminum (denoted by Al 4 (X) 4 NTCDA, where X denotes H, F, Cl or Br). The four hydrogen atom of NTCDA were substituted with X atoms. It was found that the electronic state of the complex in the ground state is composed of a charge-transfer state expressed by (Al 4 ) δ+ ((X) 4 NTCDA) δ- . Also, it was predicted that the binding energy of the Al atom was enhanced by the halogen substitution, indicating that the complex of (X) 4 NTCDA (X = halogen atoms) is more stable in terms of energy than that of pure NTCDA (X=H). The large binding energy results in the high material stability in atmosphere. By photoirradiation of the complex, the interaction between Al and NTCDA was changed from ionic to covalent. This electronic excitation was assigned to the back donation of an electron from NTCDA to Al, and it was predicted theoretically that the absorption spectrum appears as a charge-transfer (CT) band in the near infrared region. The effects of halogen-substitution on the electronic states of NTCDA are discussed on the basis of theoretical results.
A replication cut for two-way partitioning (1995)

Graph partitioning is crucial in multiple-chip design, floorplanning and mapping large logic networks into multiple FPGA's. Replication logic can be used to improve the partitioning. Given a network G with only two-pin nets and a pair of nodes s and t to be separated, we introduce a replication graph and an O(mn log(n/sup 2//m)) algorithm for optimum partitioning with replication and without size constraints, where m and n denote the number of nets and the number of nodes in G, respectively. In VLSI designs, each partition has size constraints and the given network contains multiple-pin nets. A heuristic extension is adopted to construct replication graphs with multiple-pin nets. Then we use a directed Fiduccia-Mattheyses algorithm in the constructed replication graph to solve the replication cut problem with size constraints.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Distributed PCI Assignment in LTE Based on Consultation Mechanism (2010)

Physical Cell Identity (PCI) is cell identifier on the physical layer which can be used to create synchronization signals. There is a mapping between synchronization signals and physical cell identity, and then User Equipment (UE) can search cells through this mapping. Traditionally, PCI was configured during network planning process. While with 3G Long Term Evolution (LTE) has been prevalent in the future network, auto configuration of radio parameters has become a necessity. This paper proposed a distributed PCI assignment method based on consultation mechanism for automatic configuration of locally-unique PCI. This method which is implemented in eNBs, first receives a PCI list from OAM, and then obtains the neighbor information through interaction between X2 interfaces of eNBs; in particular, a consultation mechanism is required by the candidate eNBs to determine sequence and time for responding to the initiated eNBs when more than one eNB request for neighbor cell information. After that, the initiating eNB is responsible to create suitable PCIs for its cells from the PCI list which exclude the PCIs appeared in neighbor cells.
The Fanconi anemia polypeptide FACC is localized to the cytoplasm. (1994)

Fanconi anemia (FA) is an autosomal recessive disease characterized by congenital anomalies, aplastic anemia, and chromosomal instability. A cDNA encoding the FA complementation group C (FACC) polypeptide was recently cloned [Strathdee, C. A., Gavish, H., Shannon, W. R. & Buchwald, M. (1992) Nature (London) 356, 763-767]. To further characterize this polypeptide, we generated a rabbit polyclonal antiserum against its carboxyl terminus. We used this antiserum to analyze the FACC polypeptide from normal or mutant (FA) lymphoblast cell lines. By immunoprecipitation, the wild-type FACC was a 60-kDa protein, consistent with its predicted molecular mass. FA group C cell lines expressed full-length FACC, truncated FACC, or no detectable FACC polypeptide. In addition, the antiserum specifically immunoprecipitated a 50-kDa and a 150-kDa FACC-related protein (FRP-50 and FRP-150). Unexpectedly, cell fractionation and immunofluorescence studies demonstrated that the FACC polypeptide localizes to the cytoplasm. In conclusion, we have generated an antiserum specific for the human FACC polypeptide. The antiserum should be useful for screening FA cells for mutant FACC polypeptides and for identifying and cloning FACC-related proteins.
Confirmatory methods for the thermal energy determination of N-nitroso compounds at trace levels (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConfirmatory methods for the thermal energy determination of N-nitroso compounds at trace levelsI. S. Krull, E. U. Goff, G. G. Hoffman, and D. H. FineCite this: Anal. Chem. 1979, 51, 11, 1706–1709Publication Date (Print):September 1, 1979Publication History Published online1 May 2002Published inissue 1 September 1979https://pubs.acs.org/doi/10.1021/ac50047a028https://doi.org/10.1021/ac50047a028research-articleACS PublicationsRequest reuse permissionsArticle Views97Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification of a novel Bcl‐xL phosphorylation site regulating the sensitivity of taxol‐ or 2‐methoxyestradiol‐induced apoptosis (2003)

Bcl-xL, a close homolog of Bcl2, is an important regulator of apoptosis and is overexpressed in human cancer. Phosphorylation of Bcl-xL can be induced by microtubule-damaging drugs such as taxol or 2-methoxyestradiol (2-ME). By site-directed mutagenesis studies, we have identified that serine 62 is the necessary site for taxol- or 2-ME-induced Bcl-xL phosphorylation in prostate cancer cells. Further studies with the inhibitor of Jun kinase (JNK) and phosphorylation null mutant of Bcl-xL reveal the augmentative role of JNK-mediated Bcl-xL phosphorylation in apoptosis of prostate cancer cells. In summary, our studies suggest that the phosphorylation of Bcl-xL by stress response kinase signaling might oppose the anti-apoptotic function of Bcl-xL to permit prostate cancer cells to die by apoptosis.
The proteolytic digestion of ox neurofilaments with trypsin and α-chymotrypsin (1983)

Brief digestion of ox neurofilaments with trypsin liberates fragments that are soluble and have molecular weights ranging from 164 000 to 97 000. Peptide fingerprinting indicates that these regions, termed the tryptic head-regions, arise from the 205 000- and 158 000-mol.wt. components of the triplet. The remains of the parent polypeptides sediment with normal filaments and have been termed tail-regions. Digestion of neurofilaments with chymotrypsin also liberates soluble fragments (chymotryptic head-regions) but these have mol.wts. 171 000 and 119 000, though they too originate from the higher-molecular-weight triplet polypeptides. Tryptic and chymotryptic head-regions have extensive homology, and a low (less than or equal to 20%) helix content. Electron microscopy shows that chymotryptic digestion rapidly reduces the length of filaments, probably because this enzyme preferentially attacks the 72 000-mol.wt. polypeptide. In contrast, brief digestion with trypsin does not reduce filament length even though more than 90% of the two higher-molecular-weight components have been cleaved. These results indicate that the backbone of native filaments is formed from the 72 000-mol.wt. polypeptide together with the tail-regions from the 205 000- and 158 000-mol.wt. polypeptides. The corresponding head-regions of these components, which can represent nearly 75% of each molecule, are not necessary for preserving the backbone of native neurofilaments and are therefore good candidates for being the side arms that connect these filaments in nerve cells.
The discussion of intensive use and spatial disposition pattern of countryside land resources - on the basis of the increase and decrease in city construction land. (2010)

In order to propose guarantee measures,taking Xindu district of Chengdu as an example,intensive use and spatial disposition pattern of countryside land resources were discussed in present study.The results indicated that farmland could be increased 0.94ha by the spatial disposing land resources and linking the increase in land use of urban construction.When 9.53ha construction level was used for farmers concentrated residential areas,37.03ha construction land index was saved.So,the model of linking the increase in land used for urban construction with the decrease in land used for rural construction is one of the most important ways to relive contradiction between urban construction and rural construction,protect farmland,promote intensive land use and push harmonious development of urban and rural.
Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency (2011)

Inhibition of the MDM2-p53 interaction has been shown to produce an antitumor effect, especially in MDM2 amplified tumors. The isoindolinone scaffold has proved to be versatile for the discovery of MDM2-p53 antagonists. Optimization of previously reported inhibitors, for example, NU8231 (7) and NU8165 (49), was guided by MDM2 NMR titrations, which indicated key areas of the binding interaction to be explored. Variation of the 2-N-benzyl and 3-alkoxy substituents resulted in the identification of 3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cyclopropyl)methoxy)-2-(4-nitrobenzyl)isoindolin-1-one (74) as a potent MDM2-p53 inhibitor (IC(50) = 0.23 ± 0.01 μM). Resolution of the enantiomers of 74 showed that potent MDM2-p53 activity primarily resided with the (+)-R-enantiomer (74a; IC(50) = 0.17 ± 0.02 μM). The cellular activity of key compounds has been examined in cell lines with defined p53 and MDM2 status. Compound 74a activates p53, MDM2, and p21 transcription in MDM2 amplified cells and shows moderate selectivity for wild-type p53 cell lines in growth inhibition assays.
Computational and human observer image quality evaluation of low dose, knowledge‐based CT iterative reconstruction (2015)

IMR improves detectability over FBP and may enable significant dose reductions. A channelized Hotelling observer with internal noise proportional to channel output standard deviation agreed well with human observers across a wide range of variables, even across reconstructions with drastically different image characteristics. Utility of the model observer was demonstrated by predicting the effect of image processing (blending), analyzing detectability improvements with IMR across dose, size, and contrast, and in guiding real CT scan dose reduction experiments. Such a model observer can be applied in optimizing parameters in advanced iterative reconstruction algorithms as well as guiding dose reduction protocols in physical CT experiments.
Detection of weakly absorbing gases using a resonant optoacoustic method (1976)

Recently developed optoacoustic techniques have greatly expanded our capability of measuring ultralow concentrations of infrared absorbing gases. Devices of this type include both the spectrophone which was introduced by Kreuzer in 1971 and the resonant spectrophone first considered by Dewey, Kamm, and Hackett in 1973. The advantage in the resonant method lies in the capability of accumulating energy in a standing acoustic wave, thereby providing for an effective means of signal amplification. In this paper we present the theory for the resonant acoustic response to an excitation of known characteristics with particular emphasis placed on the dissipative processes which act to limit the extent of resonant enhancement. We also investigate both theoretically and experimentally the effect of a multiple-pass configuration in which the laser beam undergoes numerous reflections, thereby increasing the total energy imparted to the gas. This description leads to a means of objectively comparing a resonant optoacoustic system to other detection devices. This same approach introduces an expression which can be used to optimize the resonant technique with respect to the variable parameters.
ChemInform Abstract: N‐ETHYLMORPHOLINIUM MOLYBDATES AND TUNGSTATES (1976)

Abstract Das Tetramolybdat und Tetra‐ , wolframat (I) werden durch 1:5‐molare Reaktion der Metalltrioxide mit N‐Äthylmorpholin in wäßriger Lösung dargestellt und durch Behandlung ihrer Lösung mit H25 in Gegenwart freier Base in die Tetrathiometallate (II) übergeführt.
Epitaxial growth of Eu2O3 thin films on LaAlO3 substrates by polymer-assisted deposition (2004)

Eu 2 O 3 thin films were epitaxially grown on (001)LaAlO3(LAO) substrates using a polymer-assisted deposition technique. Microstructural studies by x-ray diffraction and transmission electron microscopy show that the films are epitaxial with an orientational relationship of (001)Eu2O3∥(001)LAO and [11¯0]Eu2O3∥[100]LAO. We have found a systematic change in the out-of-plane lattice parameter of Eu2O3(a⊥) with the annealing temperature, which is believed to be from different strain effects.
Dead/alive bacteria detection using an all-fibre optical system (2014)

Accurate monitoring of microbial viability plays an essential role in pharmacodynamic studies such as in estimating the efficiency of antimicrobial agents. Traditionally, bacterial viability is determined by their ability to form colonies on solid growth medium or to proliferate in liquid nutrient broths but, with these culture-based methods, the live bacterial population can only be estimated retrospectively. To address this challenge, we have employed differential fluorescence staining and an all-fiber optical system developed by our group. The detection is based on the collection of the fluorescence from commercial dyes that produce a substantially increased signal upon binding with bacterial nucleic acids. The dyes allow discrimination between alive and dead cells through differential membrane permeability and fluorescence wavelength. The respective fluorescence signal is correlated to the number of bacterial cells present in the sample. Our setup uses DPSS lasers and a sensitive CCD-based spectrometer over the 400-800 nm wavelength range. A laser shutter allows the sample exposure time and acquisition time to be synchronized to minimize the effect of photobleaching. As a model, bacteria (Escherichia coli or Staphylococcus aureus) killed with isopropyl alcohol were mixed with live cells at different ratios. The population ratios of alive and dead cells were accurately quantified by our optical setup providing a rapid method for the estimation of bactericidal treatments. In summary, our optical system may offer a robust, accurate and fast alternative for detection of dead/alive bacteria in turbid solution opening the new avenues for pharmacodynamic studies.
Bag-of-visual-words models for adult image classification and filtering (2008)

We present a method to classify images into different categories of pornographic content to create a system for filtering pornographic images from network traffic. Although different systems for this application were presented in the past, most of these systems are based on simple skin colour features and have rather poor performance. Recent advances in the image recognition field in particular for the classification of objects have shown that bag-of-visual-words-approaches are a good method for many image classification problems. The system we present here, is based on this approach, uses a task-specific visual vocabulary and is trained and evaluated on an image database of 8500 images from different categories. It is shown that it clearly outperforms earlier systems on this dataset and further evaluation on two novel web-traffic collections shows the good performance of the proposed system.
Structure-Directing Agent Governs the Location of Silanol Defects in Zeolites (2015)

International audience
AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteins (2003)

The most common form of blindness at birth, Leber's congenital amaurosis (LCA), is inherited in an autosomal recessive fashion. Mutations in six different retina-specific genes, including a recently discovered gene, AIPL1, have been linked to LCA in humans. To understand the molecular basis of LCA caused by aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) mutations, and to elucidate the normal function of AIPL1, we performed a yeast two-hybrid screen using AIPL1 as bait. The screen demonstrated that AIPL1 interacts specifically with farnesylated proteins. Mutations in AIPL1 linked to LCA compromise this activity. These findings suggest that the essential function of AIPL1 within photoreceptors requires interactions with farnesylated proteins. Analysis of isoprenylation in cultured human cells shows that AIPL1 enhances the processing of farnesylated proteins. Based on these findings, we propose that AIPL1 interacts with farnesylated proteins and plays an essential role in processing of farnesylated proteins in retina.
Location privacy in database-driven Cognitive Radio Networks: Attacks and countermeasures (2013)

Cognitive Radio Network (CRN) is regarded as a promising way to address the increasing demand for wireless channel resources. It solves the channel resource shortage problem by allowing a Secondary User (SU) to access the channel of a Primary User (PU) when the channel is not occupied by the PU. The latest FCC's rule in May 2012 enforces database-driven CRNs, in which an SU queries a database to obtain spectrum availability information by submitting a location based query. However, one concern about database-driven CRNs is that the queries sent by SUs will inevitably leak the location information. In this study, we identify a new kind of attack against location privacy of database-drive CRNs. Instead of directly learning the SUs' locations from their queries, our discovered attacks can infer an SU's location through his used channels. We propose Spectrum Utilization based Location Inferring Algorithm that enables the attacker to geo-locate an SU. To thwart location privacy leaking from query process, we propose a novel Private Spectrum Availability Information Retrieval scheme that utilizes a blind factor to hide the location of the SU. To defend against the discovered attack, we propose a novel prediction based Private Channel Utilization protocol that reduces the possibilities of location privacy leaking by choosing the most stable channels. We implement our discovered attack and proposed scheme on the data extracted from Google Earth Coverage Maps released by FCC. Experiment results show that the proposed protocols can significantly improve the location privacy.
3D detectors with high space and time resolution (2018)

For future high luminosity LHC experiments it will be important to develop new detector systems with increased space and time resolution and also better radiation hardness in order to operate in high luminosity environment. A possible technology which could give such performances is 3D silicon detectors. This work explores the possibility of a pixel geometry by designing and simulating different solutions, using Sentaurus Tecnology Computer Aided Design (TCAD) as design and simulation tool, and analysing their performances. A key factor during the selection was the generated electric field and the carrier velocity inside the active area of the pixel.