gebhart/patrepeval huggingface dataset:
Formation of antibiotic, biodegradable/bioabsorbable polymers by processing with neomycin sulfate and its inclusion compound with ?-cyclodextrin (1999)

Samples of pure neomycin sulfate and its inclusion compound (IC) with β-cyclodextrin were implanted into films of poly(L-lactic acid) (PLLA) and poly(ε-caprolactone) (PCL). Both polymers have been widely used commercially to make sutures. The antibacterial activity of these films against Escherichia coli was tested. Films made by either solution casting or melt pressing were divided into the following three groups: (1) plain polymer films, (2) those embedded with pure neomycin sulfate, and (3) those embedded with neomycin sulfate-β-cyclodextrin IC. Filter paper treated with 1.5 μL of 10 mg/μL Kanamycin and neomycin were used as controls and resulted in 11- and 8-mm zones of inhibition/or antibacterial activity, respectively. Small discs (ca. 2% of total area) cut from solution-cast films of PLLA and PCL containing 50 wt % neomycin sulfate IC had 17- and 16-mm zones of inhibition, and PLLA and PCL containing 50 wt % pure neomycin sulfate deterred bacterial growth, resulting in 19-mm zones of inhibition. Melt-pressed films containing 10 wt % pure neomycin sulfate or its IC, showed 17- and 11-mm zones of inhibition for PLLA films, respectively, while PCL films showed 13- and 9-mm zones of inhibition, respectively. For melt-pressed films that contain 0.01 wt % pure neomycin sulfate or its IC, PLLA films showed 11- and 9.5-mm zones of inhibition, respectively, while PCL films showed 11- and 10-mm zones of inhibition, respectively. Since an antibiotic, bioabsorbable suture does not require surgical removal, implanting an inclusion compound in the suture might allow the slow release of antibiotic, thereby guarding against postsurgical infection and also protecting the antibiotic from degradation during the melt-spinning process used to make the suture. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 74: 937–947, 1999
Substrate Integrated Waveguide (SIW)-Based Wireless Temperature Sensor for Harsh Environments (2018)

This paper presents a new wireless sensor structure based on a substrate integrated circular waveguide (SICW) for the temperature test in harsh environments. The sensor substrate material is 99% alumina ceramic, and the SICW structure is composed of upper and lower metal plates and a series of metal cylindrical sidewall vias. A rectangular aperture antenna integrated on the surface of the SICW resonator is used for electromagnetic wave transmission between the sensor and the external antenna. The resonant frequency of the temperature sensor decreases when the temperature increases, because the relative permittivity of the alumina ceramic increases with temperature. The temperature sensor presented in this paper was tested four times at a range of 30⁻1200 °C, and a broad band coplanar waveguide (CPW)-fed antenna was used as an interrogation antenna during the test process. The resonant frequency changed from 2.371 to 2.141 GHz as the temperature varied from 30 to 1200 °C, leading to a sensitivity of 0.197 MHz/°C. The quality factor of the sensor changed from 3444.6 to 35.028 when the temperature varied from 30 to 1000 °C.
High Picture Quality Digital TV for NTSC and PAL Systems (1984)

A new digital TV for both the NTSC and the PAL systems has been developed. High picture quality was obtained by using a 2-line memory for the Y/C separation and the contour correction. Also, this digital TV is so designed that new features can be easily added to it.
zhong guo zheng quan shi chang xin xi pi lu cun zai de wen ti (2007)

证券市场信息披露制度有利于保护投资者权益并能促进证券市场健康、有序发展.我国证券市场由于监管不到位,导致上市公司在信息披露过程中不规范,对投资者特别是中小投资者的保护力度不足.本文通过对我国证券市场信息披露现状的阐述,给出了规范其市场的相关建议.
TaylorBoost: First and second-order boosting algorithms with explicit margin control (2011)

A new family of boosting algorithms, denoted Taylor-Boost, is proposed. It supports any combination of loss function and first or second order optimization, and includes classical algorithms such as AdaBoost, Gradient-Boost, or LogitBoost as special cases. Its restriction to the set of canonical losses makes it possible to have boosting algorithms with explicit margin control. A new large family of losses with this property, based on the set of cumulative distributions of zero mean random variables, is then proposed. A novel loss function in this family, the Laplace loss, is finally derived. The combination of this loss and second order TaylorBoost produces a boosting algorithm with explicit margin control.
Hyperphagia as a Mediator of Renal Disease Initiation in Obese Zucker Rats (2001)

Prevention of overeating in young OZR normalizes albuminuria and attenuates the pathogenic alterations in glomerular gene expression seen at the initiation of renal disease in obese animals allowed to feed ad libitum. This model may be relevant for studying the early end-organ effects of obesity.
Effects of T142 Phosphorylation and Mutation R145G on the Interaction of the Inhibitory Region of Human Cardiac Troponin I with the C-Domain of Human Cardiac Troponin C (2002)

Cardiac troponin I (cTnI) is the inhibitory component of the troponin complex, and its interaction with cardiac troponin C (cTnC) plays a critical role in transmitting the Ca(2+) signal to the other myofilament proteins in heart muscle contraction. The switch between contraction and relaxation involves a movement of the inhibitory region of cTnI (cIp) from cTnC to actin-tropomyosin. This region of cTnI is prone to missense mutations in heart disease, and a specific mutation, R145G, has been associated with familial hypertrophic cardiomyopathy. It also contains the unique cardiac PKC phosphorylation site at residue T142. To determine the structural consequences of the mutation R145G and the T142 phosphorylation on the interaction of cIp with cTnC, we have utilized 2D [(1)H, (15)N]-HSQC NMR spectroscopy to monitor the binding of native cIp, cIp-R (R145G), and cIp-P (phosphorylated T142), respectively, to the Ca(2+)-saturated C-domain of cTnC (cCTnC.2Ca(2+)). We also report a strategy for cloning, expression, and purification of cTnI peptide, and both synthetic and recombinant peptides are used in this study. NMR chemical shift mapping indicates that the binding epitope of cIp on cCTnC.2Ca(2+) is not greatly affected, but the affinity is reduced by approximately 14-fold by the T142 phosphorylation and approximately 4-fold by the mutation R145G, respectively. This suggests that these modifications of cIp have an adverse effect on the binding of cIp to cCTnC.2Ca(2+). These perturbations may correlate with the impairment or loss of cTnI function in heart muscle contraction.
Torsional Dynamics of Generator Units During Sudden Impact Load (2012)

The aim of this paper is to analyze the dynamics of generator units during sudden impact load, direct-on-line starting loaded induction motors connected to a synchronous generator in autonomous operation. A complex mathematical model of isolated electrical grid consisting of: diesel engine, synchronous generator and motor drives have been developed. In the previous works, most often in case of direct starting of the induction motor to the grid, the torsional dynamics of the unit was not analyzed consistently, but rather the whole generator-unit was considered as a single rotating mass. Here, system with two rotating masses, one at the side of the diesel engine and the other at the side of the synchronous generator is analyzed. Ship electrical grids have such units with a diesel engine and a synchronous generator as sources. Connection of bigger induction motors to the ship's grid with such sources is the most difficult transition regime for units due to electricity loads and also due to the torsional strains in the shaft lines. This paper attempts to analyze the torsional dynamics, combining thus the knowledge in this field with the knowledge of motor drives with induction motors. The dynamics of generator-units, as well as induction motors during direct-on-line starting on isolated electrical grid is analyzed.
Controlling Domain Orientations in Thin Films of AB and ABA Block Copolymers (2011)

Domain orientations in thin films of lamellar copolymers are evaluated as a function of copolymer architecture, film thickness, and processing conditions. Two copolymer architectures are considered: An AB diblock of poly(styrene-b-methyl methacrylate) and an ABA triblock of poly(methyl methacrylate-b-styrene-b-methyl methacrylate). All films are cast on substrates that are energetically neutral with respect to the copolymer constituents. Film structures are evaluated with optical microscopy, atomic force microscopy, and grazing-incidence small-angle X-ray scattering. For AB diblock copolymers, the domain orientations are very sensitive to film thickness, annealing temperature, and imperfections in the “neutral” substrate coating: Diblock domains are oriented perpendicular to the substrate when annealing temperature is elevated (≥220 °C) and defects in the substrate coating are minimized; otherwise, parallel or mixed parallel/perpendicular domain orientations are detected for most film thicknesses. For ABA triblock copolymers, the perpendicular domain orientation is stable for all the film thicknesses and processing conditions that were studied. The orientations of diblock and triblock copolymers are consistent with recent works that consider architectural effects when calculating the copolymer surface tension (Macromolecules 2006, 39, 9346 and Macromolecules 2010, 43, 1671). Significantly, the data demonstrate that triblocks are easier to process for applications in nanopatterning—in particular, when high-aspect-ratio nanostructures are required. However, both diblock and triblock films contain a high density of “tilted” or bent domains, and these kinetically trapped defects should be minimized for most patterning applications.
Oxidative mechanisms in carcinogenesis (1993)

Cancer in humans and animals is a multistep disease process. In this process, a single cell can develop from an otherwise normal tissue into a malignancy that can eventually destroy the organism. The complex series of cellular and molecular changes that occur through the development of cancers can be mediated by a diversity of endogenous and environmental stimuli. Active oxygen species and other free radicals have long been known to be mutagenic; further, these agents have more recently emerged as mediators of the other phenotypic and genotypic changes that lead from mutation to neoplasia. Free radical production is ubiquitous in all respiring organisms, and is enhanced in many disease states, by carcinogen exposure, and under conditions of stress. Free radicals may therefore contribute widely to cancer development in humans. This review explores the molecular mechanisms through which free radicals can participate in the carcinogenic process.
Gut mucosal immunostimulation by lactic acid bacteria. (2000)

The beneficial properties of lactic acid bacteria (LAB) on human health have been frequently demonstrated. The interaction of LAB with the lymphoid cells associated to the gut to activate the mucosal immune system and the mechanisms by which they can exert an adjuvant effect is still unclear, as well as if this property is common for all the LAB. We studied the influence of the oral administration of different geneous of LAB such as Lactobacillus casei, L. acidophilus, L. rhamnosus, L. delbrueckii subsp. bulgaricus, L. plantarum, Lactococcus lactis and Streptococcus thermophilus. We determined if the LAB assayed were able to stimulate the specific, the non-specific immune response (inflammatory response), or both. We demonstrated that all the bacteria assayed were able to increase the number of IgA producing cells associated to the lamina propria of small intestine. This effect was dose dependent. The increase in IgA+ producing cells was not always correlated with an increase in the CD4+ T cell number, indicating that some LAB assayed only induced clonal expansion of B cells triggered to produce IgA. Most of them, induced an increase in the number of cells involved in the inflammatory immune response. CD8+ T cell were diminished or not affected, with exception of L. plantarum that induced an increase at low dose. This fact would mean that LAB are unable to induce cytotoxicity mechanisms. We demonstrated the importance in the selection of LAB to be used as gut mucosal adjuvant. The different behaviours observed among them on the gut mucosal immune response, specially those that induce inflammatory immune response, show that not all the LAB can be used as oral adjuvant and that the beneficial effect of them can not generalized to genous or specie. The immunoadjuvant capacity would be a property of the strain assayed.
The Best 9X9 Square Yet (1991)

On December 28, 1897 the first 9X9 word square in history was published. It was constructed by Arthur F. Holt, the master formist of his time, and appeared in the Chicago Inter-Ocean, back when newspapers were enlightened enough to carry that sort of thing. Given the incredible difficulty of building such a form, it is not surprising that the square contained words taken from a variety of sources.
High‐Performance Nonvolatile Transistor Memories of Pentacence Using the Green Electrets of Sugar‐based Block Copolymers and Their Supramolecules (2014)

Reported here are the nonvolatile electrical characteristics of pentacene‐based organic field‐effect transistor (OFET) memory devices created from the green electrets of sugar‐based block copolymer maltoheptaose ‐block‐ polystyrene (MH ‐b‐ PS), and their supramolecules with 1‐aminopyrene (APy). The very hydrophilic and abundant‐hydroxyl MH block is employed as a charge‐trapping site, while the hydrophobic PS block serves as a matrix as well as a tunneling layer. The orientation of the MH nanodomains could be well controlled in the PS matrix with random spheres, vertical cylinders, and ordered horizontal cylinders via increasing solvent annealing time, leading to different electrical switching characteristics. The electron‐trapping ability induced by the horizontal‐cylinder MH is stronger than those of the random‐sphere and vertical‐cylinder structures, attributed to the effective contact area. The electrical memory window of the device is further improved via the supramolecules of hydrogen‐bonding 1‐aminopyrene to the MH moieties of MH ‐b‐ PS for enhancing the hole‐trapping ability. The optimized device using the horizontal cylinders of the supramolecule electret exhibits the excellent memory characteristics of a wide memory window (52.7 V), retention time longer than 10 4 s with a high ON/OFF ratio of >10 5 , and stable reversibility over 200 cycles. This study reveals a new approach to achieve a high‐performance flash memory through the morphology control of sugar‐based block copolymers and their supramolecules.
Complement activation-related cardiac anaphylaxis in pigs: role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function (2005)

Cardiac anaphylaxis is a severe, life-threatening manifestation of acute hypersensitivity reactions to allergens and drugs. Earlier studies highlighted an amplifying effect of locally applied C5a on the process; however, the role of systemic complement (C) activation with C5a liberation in blood has not been explored to date. In the present study, we used the porcine liposome-induced cardiopulmonary distress model for 1) characterizing and quantifying peripheral C activation-related cardiac dysfunction; 2) exploring the role of C5a in cardiac abnormalities and therapeutic potential of C blockage by soluble C receptor type 1 (sCR1) and an anti-C5a antibody (GS1); and 3) elucidating the role of adenosine and adenosine receptors in paradoxical bradycardia, one of the symptoms observed in this model. Pigs were injected intravenously with different liposomes [Doxil and multilamellar vesicles (MLV)], zymosan, recombinant human (rhu) C5a, and adenosine, and the ensuing hemodynamic and cardiac changes (hypotension, tachy- or bradycardia, arrhythmias, ST-T changes, ventricular fibrillation, and arrest) were quantified by ranking on an arbitrary scale [cardiac abnormality score (CAS)]. There was significant correlation between CAS and C5a production by liposomes in vitro, and the liposome-induced cardiac abnormalities were partially or fully reproduced with zymosan, rhuC5a, adenosine, and the selective adenosine A1 receptor agonist cyclopentyl-adenosine. The use of C nonactivator liposomes or pretreatment of pigs with sCR1 or GS1 attenuated the abnormalities. The selective A1 blocker cyclopentyl-xanthine inhibited bradycardia without influencing hypotension, whereas the A(2) blocker 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol (ZM-24135) had no such effect. These data suggest that 1) systemic C activation can underlie cardiac anaphylaxis, 2) C5a plays a causal role in the reaction, 3) adenosine action via A1 receptors may explain paradoxical bradycardia, and 4) inhibition of C5a formation or action or of A1-receptor function may alleviate the acute cardiotoxicity of liposomal drugs and other intravenous agents that activate C.
Seismic group recorder system (1982)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1982Seismic group recorder systemAuthors: David G. ShaveDavid G. ShaveGus Manufacturing, Inc.https://doi.org/10.1190/1.1827090 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1827090FiguresReferencesRelatedDetailsCited ByRecent advances in nodal land seismic acquisition systems11 November 2019 | ASEG Extended Abstracts, Vol. 2019, No. 1 SEG Technical Program Expanded Abstracts 1982ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1982 Pages: 520 publication data© 1982 Copyright © 1982 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 24 Mar 2005 CITATION INFORMATION David G. Shave, (1982), "Seismic group recorder system," SEG Technical Program Expanded Abstracts : 45-46. https://doi.org/10.1190/1.1827090 Plain-Language Summary PDF DownloadLoading ...
Stereoselective total syntheses of the antitumor antibiotics (+)-actinobolin and (-)-bactobolin from a common bridged lactone intermediate (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselective total syntheses of the antitumor antibiotics (+)-actinobolin and (-)-bactobolin from a common bridged lactone intermediateRavi S. Garigipati, David M. Tschaen, and Steven M. WeinrebCite this: J. Am. Chem. Soc. 1990, 112, 9, 3475–3482Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/ja00165a035https://doi.org/10.1021/ja00165a035research-articleACS PublicationsRequest reuse permissionsArticle Views763Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
State of the Art. Role of CD4+ T Cells in Sarcoidosis (2007)

Activated pulmonary CD4(+) T lymphocytes of the Th-1 type are essential for the inflammatory process in sarcoidosis, and IFN-gamma production is crucial for the characteristic granuloma formation. Both the T cells and their inflammatory mediators may constitute possible targets for immunotherapy. A particular T-cell subset, the T-cell receptor (TCR) AV2S3(+) bronchoalveolar lavage (BAL) CD4(+) T cells, is found at dramatically increased levels in the BAL fluid of human leukocyte antigen (HLA)-DRB1*0301-positive and/or HLA-DRB3*0101-positive patients with sarcoidosis. The AV2S3(+) BAL CD4(+) T cells strongly associate with the sarcoid inflammation, and future studies on this particular T-cell subset to reveal their specificity may lead to the identification of sarcoidosis-specific antigen(s). T-cell subpopulations with regulatory functions (i.e., natural killer T cells and T regulatory cells) have recently been described as abnormal in sarcoidosis. Dysfunctional regulatory T cells may allow T effector cells to contribute to the formation of granulomas, and they may thus be relevant for the inflammatory process in this disease. These findings are exciting news and will be of help in designing new treatment strategies.
History of the concept of tolerance (1963)

(1963). History of the concept of tolerance. Pacific Philosophy Forum: Vol. 2, No. sup1, pp. 4-10.
3 Chloroplast and Mitochondrial DNAs of Arabidopsis thaliana: Conventional Genomes in an Unconventional Plant (1994)

Many of the unusual features that make Arabidopsis thaliana such an attractive model system for flowering plants relate, either directly or indirectly, to its unconventional nuclear genome. Of paramount importance, the notably small size of this genome, together with the relative lack of repeated sequences and reduced size of many introns and gene families, directly facilitates efforts to map, isolate, and characterize genes. Indirectly, the small size of the nuclear genome may be related to, perhaps in some measure responsible for, the reduced size of the plant and length of its life cycle, features that considerably enhance its genetic tractability. The chloroplast and mitochondrial genomes of Arabidopsis have not shared the limelight with its nuclear genome. This is in part because these organellar genomes have not, until recently, been subject to much experimental study and also because they appear, in distinct contrast to the nuclear genome, to be utterly conventional in all important respects. The primary goal of this chapter is to show how the chloroplast DNA (cpDNA) and mitochondrial DNA (mtDNA) of Arabidopsis are typical of flowering plant organellar genomes in terms of size, organization, content of repeats and genes, gene structure, and, probably, modes of expression and regulation. In terms of direct molecular characterization, the Arabidopsis mitochondrial genome should soon assume primacy among flowering plant mtDNAs, thanks to a genome-sequencing project that is now more than half complete. A secondary goal of this chapter is to describe what we view as the proper and rightful swing of the...