gebhart/patrepeval huggingface dataset:
MetaSync: Coordinating Storage across Multiple File Synchronization Services (2016)

Cloud-based file synchronization services such as Dropbox are a worldwide resource for many millions of users. However, individual services often have tight resource limits, suffer from temporary outages or shutdowns, and sometimes silently corrupt or leak user data. As a solution, the authors design, implement, and evaluate MetaSync, a secure and reliable file synchronization service using multiple cloud synchronization services as untrusted storage providers. To provide global consistency among the storage providers, the authors devise a novel variant of Paxos that enables efficient updates on top of the unmodified APIs exported by each service. MetaSync provides better availability and performance, stronger confidentiality and integrity, and larger storage for end users.
Plasma quinine levels in patients with falciparum malaria when given alone or in combination with tetracycline with or without primaquine. (1991)

Quinine has been an effective drug for severe chloroquine-resistant falciparum malaria. However, there has been a decline in the sensitivity of Plasmodium falciparum to quinine. In 1978-1979 the cure rate was 94% compared to 86% in 1979-1980 and 76% in 1980-1981. The combination of quinine and tetracycline has improved the cure rate to 95-100%. However, the mechanism responsible for this has not been identified. We have compared plasma quinine levels on day 2, day 5 and day 7 (before and at 2 hours after dosing) in twenty-one patients with acute falciparum malaria who were treated with quinine alone (8 patients) or quinine in combination with tetracycline (8 patients) or quinine with tetracycline and primaquine (5 patients). All patients who received combination of quinine and tetracycline with or without primaquine responded well to the treatment with no recrudescence. Two patients who were treated with quinine alone had RI responses. Plasma quinine concentrations from the quinine alone group were significantly lower than those obtained from combination groups on days 2, 5 and 7. The minimal plasma quinine levels from quinine alone group were all lower than MIC, ie below 10 micrograms/ml while those obtained from the combination group were higher than MIC for 7 days. The results from the present study suggest that tetracycline has influence on the maintenance of plasma quinine levels above MIC throughout the treatment period. Therefore, this must be one possible explanation for the better cure rate.
Polymeric optical mixing rod coupler (1990)

Optical mixing rod couplers have been fabricated using extruded plastic tubing filled with optically transparent casting resins to form a waveguide-type mixing region. Asymmetric (1*19) splitter/combiners with plastic fiber and plastic-clad silica fiber pigtails have been made with efficiencies greater than 60% and power uniformities within 1-dB standard deviation. Tested as a combiner, the coupler had an average loss of -1.6 dB with a standard deviation of 0.71 dB. Tested as a splitter, it had an average loss of -14.9 dB with a standard deviation of 0.9 dB, and the excess loss was -2.0 dB. The results suggest that the coupler would be useful in a variety of short-distance optical interconnection applications where multimode step-index fiber is appropriate. It may also offer a higher yield than some competing, more complex techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Performance Comparison of Weather Disruption-Tolerant Cross-Layer Routing Algorithms (2009)

With growing demand for high-speed access to mobile handheld devices, there is a significant cost benefit in deploying fixed wireless-mesh networks for backhaul access. However, enabling reliable broadband access over high-frequency radios (such as millimeter-wave networks) posses a fundamental challenge due to weather disruptions in general and rain attenuation in particular. In this paper, we present an analysis of the impact of precipitation on millimeter-wave mesh networks based on radar measurements of real storms in the Midwest US. Furthermore, we compare two novel algorithms that use physical-layer information to optimize routing at the network layer: P-WARP (Predictive Weather-Assisted Routing Protocol) and XL-OSPF (Cross-Layered Open Shortest Path First). Finally, we present simulation studies to compare the performance of the proposed protocols and evaluate the dependability of the end-user service during weather disruptions.
Human Slack Potassium Channel Mutations Increase Positive Cooperativity between Individual Channels (2014)

Disease-causing mutations in ion channels generally alter intrinsic gating properties such as activation, inactivation, and voltage dependence. We examined nine different mutations of the KCNT1 (Slack) Na(+)-activated K(+) channel that give rise to three distinct forms of epilepsy. All produced many-fold increases in current amplitude compared to the wild-type channel. This could not be accounted for by increases in the intrinsic open probability of individual channels. Rather, greatly increased opening was a consequence of cooperative interactions between multiple channels in a patch. The degree of cooperative gating was much greater for all of the mutant channels than for the wild-type channel, and could explain increases in current even in a mutant with reduced unitary conductance. We also found that the same mutation gave rise to different forms of epilepsy in different individuals. Our findings indicate that a major consequence of these mutations is to alter channel-channel interactions.
Classification of heparinolytic bacteria into a new genus, Pedobacter, comprising four species: Pedobacter heparinus comb. nov., Pedobacter piscium comb. nov., Pedobacter africanus sp. nov. and Pedobacter saltans sp. nov. Proposal of the family Sphingobacteriaceae fam. nov. (1998)

Sixteen heparinase-producing isolates, related to Sphingobacterium heparinum, were grouped into three major clusters by SDS-PAGE and DNA-rRNA hybridizations. Based on a polyphasic approach, it was shown that isolates of two of these clusters and S. heparinum species belong to a new genus for which the name Pedobacter is proposed. The genus consists of Pedobacter heparinus comb. nov. (formerly Sphingobacterium heparinum), which is the type species, Pedobacter piscium comb. nov. (formerly Sphingobacterium piscium), Pedobacter africanus sp. nov. and Pedobacter saltans sp. nov. and four as-yet-unnamed DNA hybridization groups. All the previously named taxa can be discriminated by phenotypic features, but have strong overall similarities with representatives of the genus Sphingobacterium and the misclassified species [Flexibacter] canadensis. All these organisms constitute a separate rRNA branch in rRNA superfamily V for which the family Sphingobacteriaceae fam. nov. is proposed.
Immunoblotting analysis of concanavalin A ‐isolated allergens of <i>Candida albicans</i> (1990)

The carbohydrate-containing fraction of Candida albicans was isolated from the crude extract with ConA Sepharose affinity chromatography and studied by IgE-immunoblotting with individual and pooled sera from C. albicans-allergic subjects. In the ConA-bound fraction there was a diffuse IgE binding in the high molecular weight area which also gave a carbohydrate stain (PAS). A distinct band corresponding to a molecular weight of 70 kD bound specific IgE antibodies. This glycoprotein, presumably a mannoprotein, gave a weak carbohydrate staining and a strong protein staining. Further biochemical studies are needed to reveal the exact nature of the epitopes in the ConA-bound mannose-containing fraction of C. albicans.
Conformational behaviour of hydroxamic acids: ab initio and structural studies (1996)

The conformational behaviour of a series of monohydroxamic acids, p-RC6H4CONR′OH (R = Me, R′= H, Me; R = MeO, R′= H, Me; R = NO2, R′= H), and a series of dihydroxamic acids, (CH2)n(CONR′OH)2(n= 3–8, 10, R′= H and n= 7, R′= Me), in methanol, DMSO and chloroform and in the solid state has been examined using IR and NMR spectroscopy. X-Ray crystal structure determinations of p-MeC6H4CONMeOH and the monohydrate of glutarodihydroxamic acid (n= 3) together with ab initio molecular orbital calculations for several hydrated and unhydrated hydroxamic acids have been performed. Hydrogen bonding effects are shown to be important in both the solid state and solution. The cis(Z) conformation of the hydroxamate group(s)(CONHOH) is preferentially stabilized by hydrogen bonding with water molecules.
HIV-1 Reverse Transcriptase Plus-strand Initiation Exhibits Preferential Sensitivity to Non-nucleoside Reverse Transcriptase Inhibitors in Vitro (2006)

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent allosteric inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. NNRTIs inhibit reverse transcription in a substrate length-dependent manner in biochemical assays and in cell-based HIV-1 replication assays, suggesting a stochastic inhibitory mechanism. Surprisingly, we observed that NNRTIs potently inhibited plus-strand initiation in vitro under conditions in which little or no inhibition of minus-strand DNA synthesis was observed. In assays that recapitulated the initiation of plus-strand DNA synthesis, greater inhibition was observed with an RNA PPT primer than with a DNA primer of corresponding sequence and with wild-type reverse transcriptase but not with NNRTI-resistant enzymes. Structural elements that dictate sensitivity to NNRTIs were revealed using modified plus-strand initiation substrates. The data presented here suggest that specific inhibition of plus-strand initiation may be an important mechanism by which NNRTIs block HIV-1 replication.
Syntheses of Discodermolides Useful for Investigating Microtubule Binding and Stabilization (1996)

Discodermolide is a marine natural product reported to inhibit the proliferation of T cells and exhibit immunosuppresive activity. Total syntheses of the natural antipode of discodermolide and several variants are reported. These studies provide reagents to investigate discodermolide's recently discovered ability to bind and stabilize microtubules in cells. Retrosynthetically, the polypropionate is divided into three fragments of approximately equal complexity. This modular strategy provides convergency in the synthesis and facilitates the preparation of discodermolide-based reagents.
Process vs. task migration (1996)

This paper describes task and process migration for the OSF/1 AD Operating System (OS server for massively parallel processors and clusters of workstations. OSF/1 AD, runs in user space, on top of the Mach microkernel. A process in the OSF/1 AD server is composed of a Mach task state (memory, capabilities, threads, etc.) and of the UNIX-related state (open file descriptors, signal masks, etc.). Process migration invokes task migration to transfer the Mach task state, and supports transparent transfer of the UNIX process state. Process and task migration rely on a single system image provided at both OSF/1 AD and Mach levels. We compare the initial and run-time costs of task and process migration for several programs with different needs. While process migration initial costs are less than 17% of task migration costs, the expected benefits can easily be as high as a 50% improvement in run-time cost over task migration. We conducted the experiments on a cluster of PCs; however, results are also applicable to massively parallel processors.
Detection of Concealed Weapons in X-Ray Images Using Fuzzy K-NN (2012)

Scanning baggage by x-ray and analysing such images have become important technique for detecting illicit materials in the baggage at Airports. In order to provide adequate security, a reliable and fast screening technique is needed for baggage examination.This paper aims at providing an automatic method for detecting concealed weapons, typically a gun in the baggage by employing image segmentation method to extract the objects of interest from the image followed by applying feature extraction methods namely Shape context descriptor and Zernike moments. Finally the objects are classified using fuzzy KNN as illicit or non-illicit object.
Cyclization of .beta.-keto sulfoxides. V. New synthetic method for condensed heterocycles, carbazoles, indoles, and benzothiophenes, based on acid-catalyzed cyclization of .beta.-keto sulfoxides (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclization of .beta.-keto sulfoxides. V. New synthetic method for condensed heterocycles, carbazoles, indoles, and benzothiophenes, based on acid-catalyzed cyclization of .beta.-keto sulfoxidesYuji Oikawa and Osamu YonemitsuCite this: J. Org. Chem. 1976, 41, 7, 1118–1124Publication Date (Print):April 1, 1976Publication History Published online1 May 2002Published inissue 1 April 1976https://pubs.acs.org/doi/10.1021/jo00869a007https://doi.org/10.1021/jo00869a007research-articleACS PublicationsRequest reuse permissionsArticle Views697Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficacy of Monensin or Amprolium in the Prevention of Hepatic Coccidiosis in Rabbits (1972)

SYNOPSIS. New Zealand White rabbits were fed monensin (Coban® Premix) or amprolium in pelleted feed as a prophylaxis against infection with Eimeria stiedai. Rabbits receiving monensin at 0.005, 0.01, or 0.02% concentrations in the feed did not become infected but ate only small amounts of pellets when the drug concentration was 0.02%. All rabbits given 0.02% amprolium in pelleted feed developed severe infections. Rabbits on “limited” (8 gm pellets per day) diets were susceptible to infection.
Challenges in CMOS mixed-signal designs for analog circuit designers (2002)

Common issues of designing analog circuits in a CMOS mixed-signal environment are summarized. Effects of power supply noise and regulation, substrate noise, cross talk, and layout and floor planning are briefly discussed and a condensed description of proposed solutions are presented. In addition, process scalability for analog circuits built in a mixed-signal chip is reviewed. Design of analog circuits with ability to scale into different CMOS technologies are often neglected in a mixed-signal design which typically culminates in major modifications, or a complete design change for the analog blocks when a the process is changed.
Effects of local Joule heating on the reduction of contact resistance between carbon nanotubes and metal electrodes (2007)

We report here a practical application of known local Joule heating processes to reduce the contact resistance between carbon nanotubes and metallic electrical contacts. The results presented in this study were obtained from a series of systematic Joule heating experiments on 289 single-walled carbon nanotubes (SWCNTs) and 107 multiwalled carbon nanotubes (MWCNTs). Our experimental results demonstrate that the Joule heating process decreases the contact resistances of SWCNTs and MWCNTs to 70.4% and 77.9% of their initial resistances, respectively. The I-V characteristics of metallic nanotubes become more linear and eventually become independent of the gate voltages (Vgs). For semiconducting nanotubes, the contact resistance has a similar decreasing tendency but the dependency of source-drain current (Ids) on Vgs does not change with the Joule heating process. This suggests that the reduction of the contact resistance and the decrease of the transport potential barrier are largely attributed to the thermal-energy-induced desorption of adsorbates such as water and oxygen molecules from the nanotube surface and the interface region, as well as thermal-energy-enhanced bonding between the nanotubes and electrode surfaces. In comparison to several other methods including rapid thermal annealing, e-beam lithography patterning of the top metal layer, and focused ion beam induced metal deposition of the top layer, the Joule heating process not only effectively reduces the contact resistance but also simultaneously measures the resistance and monitors the change in the transport potential barrier at the interface region.
Isomer‐Selective Vibrational Spectroscopy of Benzene–Acetylene Aggregates: Comparison with the Structure of the Benzene–Acetylene Cocrystal (2008)

Crystallization seeds in supersonic jets? T-shaped structures dominate the isomer-selective IR–UV double-resonance spectra of benzene–acetylene clusters in supersonic jets. The double T-shaped motif is also present in the 1:1 cocrystal (see picture).
Influence of the Linker on the Biodistribution and Catabolism of Actinium-225 Self-Immolative Tumor-Targeted Isotope Generators (2006)

Current limitations to applications of monoclonal antibody (mAb) targeted isotope generators in radioimmunotherapy include the low mAb labeling yields and the nonspecific radiation of normal tissues by nontargeted radioimmunoconjugates (RIC). Radiotoxicity occurs in normal organs that metabolize radiolabeled proteins and peptides, primarily liver and kidneys, or in radiosensitive organs with prolonged exposure to the isotope from the blood, such as the bone marrow. Actinium-225 nanogenerators also have the problem of released agar-emitting daughters. We developed two new bifunctional chelating agents (BCA) in order to address these issues. Thiol-maleimide conjugation chemistry was employed to increase the efficiency of the mAb radiolabelings by up to 8-fold. In addition, one bifunctional chelating agent incorporated a cleavable linker to alter the catabolism of the alpha-particle-emitting mAb conjugate. This linker was designed to be sensitive to cathepsins to allow release and clearance of the chelated radiometal after internalization of the radioimmunoconjugate into the cell. We compared the properties of the cleavable conjugate (mAb-DOTA-G3FC) to noncleavable constructs (mAb-DOTA-NCS and mAb-DOTA-SH). The cleavable RIC was able to release 80% of its radioactive payload when incubated with purified cathepsin B. The catabolism of the constructs mAb-DOTA-G3FC and mAb-DOTA-NCS was investigated in vitro and in vivo. RIC integrity was retained at 85% over a period of 136 h in mouse serum in vivo. Both conjugates were degraded over time inside HL-60 cells after internalization and in mouse liver in vivo. While we found that the rates of degradation of the two RICs in those conditions were similar, the amounts of the radiolabeled product residues were different. The cleavable mAb-DOTA-G3FC conjugate yielded a larger proportion of fragments below 6kDa in size in mouse liver in vivo after 12 h than the DOTA-NCS conjugate. Biodistribution studies in mice showed that the mAb-DOTA-G3FC construct yielded a higher liver dose and prolonged liver retention of radioactivity compared to the mAb-DOTA-NCS conjugate. The accumulation in the liver seemed to be in part caused by the maleimide functionalization of the antibody, since the noncleavable mAb-DOTA-SH maleimide-functionalized control conjugate displayed the same biodistribution pattern. These results provide an insight into the catabolism of RICs, by demonstrating that the release of the radioisotope from a RIC is not a sufficient condition to allow the radioactive moiety to clear from the body. The excretion mechanisms of radiolabeled fragments seem to constitute a major limiting step in the chain of events leading to their clearance.
Fast High Dimensional Vector Multiplication Face Recognition (2013)

This paper advances descriptor-based face recognition by suggesting a novel usage of descriptors to form an over-complete representation, and by proposing a new metric learning pipeline within the same/not-same framework. First, the Over-Complete Local Binary Patterns (OCLBP) face representation scheme is introduced as a multi-scale modified version of the Local Binary Patterns (LBP) scheme. Second, we propose an efficient matrix-vector multiplication-based recognition system. The system is based on Linear Discriminant Analysis (LDA) coupled with Within Class Covariance Normalization (WCCN). This is further extended to the unsupervised case by proposing an unsupervised variant of WCCN. Lastly, we introduce Diffusion Maps (DM) for non-linear dimensionality reduction as an alternative to the Whitened Principal Component Analysis (WPCA) method which is often used in face recognition. We evaluate the proposed framework on the LFW face recognition dataset under the restricted, unrestricted and unsupervised protocols. In all three cases we achieve very competitive results.
<b>The Chemistry of Carbonyl Fluoride. I. The Fluorination of Organic Compounds</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chemistry of Carbonyl Fluoride. I. The Fluorination of Organic CompoundsF. S. Fawcett, C. W. Tullock, and D. D. CoffmanCite this: J. Am. Chem. Soc. 1962, 84, 22, 4275–4285Publication Date (Print):November 1, 1962Publication History Published online1 May 2002Published inissue 1 November 1962https://pubs.acs.org/doi/10.1021/ja00881a017https://doi.org/10.1021/ja00881a017research-articleACS PublicationsRequest reuse permissionsArticle Views2097Altmetric-Citations128LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts