gebhart/patrepeval huggingface dataset:
Methylseleninic acid inhibits PMA-stimulated pro-MMP-2 activation mediated by MT1-MMP expression and further tumor invasion through suppression of NF- B activation (2006)

Selenium, an essential biological trace element, reduces the incidence of cancer. Our previous studies show that selenite inhibits tumor invasion by suppressing the expression of matrix metalloproteinases (MMP) -2 and -9. Methylseleninic acid (MSeA), an immediate precursor of methylselenol, inhibits tumor cell growth in vitro and mammary carcinogenesis in vivo. In this study, we demonstrate that MSeA suppresses pro-MMP-2 activation in a dose-dependent manner induced by 12-Otetradecanoylphorbol-13-acetate (PMA), and further decreases the invasiveness of HT1080 tumor cells. Membrane type-1-MMP (MT1-MMP) is a crucial element in the process of pro-MMP-2 activation. Pro-MMP-2 binds MT1-MMP, using tissue inhibitor of metalloproteinase-2 (TIMP-2) as an adaptor, by forming a trimolecular complex on the cell surface. MSeA blocked MT1-MMP in a dose-dependent manner, but not TIMP-2 expression. MMP-9 and TIMP-1 levels were not affected by MSeA. Selenite induced a decrease in protein levels of both pro-MMPs -9 and -2, but not active forms of pro-MMP-2. MT1-MMP expression is regulated by NF-kB. Our data show that the effect of MSeA on MT1-MMP expression is mediated through suppression of NF-kB activity. Methylselenol generated by selenomethionine (SeMet) and methioninase (METase) inhibited pro-MMP-2 activation induced by PMA, confirming the effect of MSeA on pro-MMP-2 activity. Moreover, ROS production induced by PMA was partly decreased in the presence of MSeA. This suppression of ROS production may be related to diminished NF-kB activity. Thus, our results suggest that MSeA blocks tumor invasion in vitro via inhibiting pro-MMP-2 activation mediated by suppression of MT1-MMP expression, which is regulated by the NF-kB signal pathway.
Simulating the Emergence of Mutations and Their Subsequent Evolution in an Age-Structured Stochastic Self-Regulating Process with Two Sexes (2013)

The stochastic process under consideration is intended to be not only part of the working paradigm of evolutionary and population genetics but also that of applied probability and stochastic processes with an emphasis on computer intensive methods. In particular, the process is an age-structured self-regulating multitype branching process with a genetic component consisting of an autosomal locus with two alleles for females and males. It is within this simple context that mutation will be quantified in terms of probabilities that a given allele mutates to the other per meiosis. But, unlike many models that are currently being used in mathematical population genetics, in which natural selection is often characterized in terms of parameters called fitness by genotype or phenotype, in this paper the parameterization of submodules of the model provides a framework for characterizing natural selection in terms of some of its components. One of these modules consists of reproductive success that is quantified in terms of the total expected number of offspring a female contributes to the population throughout her fertile years. Another component consists of survival probabilities that characterize an individual’s ability to compete for limited environmental resources. A third module consists of a parametric function that expresses the probabilities of survival in a birth cohort of individuals by age for both females and males. A forth module of the model as an acceptance matrix of conditional probabilities such female may show a preference for the genotype or phenotype as her male sexual partner. It is assumed that any force of natural selection acts at the level of the three genotypes under consideration for each sex. By assigning values of the parameters in each of the modules under consideration, it is possible to conduct Monte Carlo simulation experiments designed to study the effects of each component of selection separately or in any combination on a population evolving from a given initial population over some specified period of time.
Buildings Energy Efficiency and Innovative Energy Systems (2021)

The use of energy in buildings is at the crossroads between comfort and productivity requirements, passive and active technological options, and health and environmental consequences [...]
An amphibian model for developing and evaluating retinal prostheses (2002)

The current project seeks to address the problem of constructing models with which to guide the development and evaluation of retinal prosthesis designs. In particular, the efforts described in this paper are intended to develop a more complete understanding of how electrical stimulation of ganglion cells by external electrodes interacts with retinal surface tissues, and how specific stimuli are encoded by the retinal and optic nerve processing systems. Toward this end, novel surgical techniques, optic tecturm recording from live animals, correlational analysis, and systematic electrophysiological recording of stimulation are utilized. Microsurgical methods for providing a repeatable, chronic implantation of stimulating prostheses have been developed. An optoelectronic processor capable of reliably encoding wavelength-dependent intensity information, including sensitivity changes with light adaptation has also been constructed.
Computational Mapping Identifies Localized Mechanisms for Ablation of Atrial Fibrillation (2012)

Atrial fibrillation (AF) is the most common heart rhythm disorder in the Western world and a common cause of hospitalization and death. Pharmacologic and non-pharmacologic therapies have met with limited success, in part due to an incomplete understanding of the underlying mechanisms for AF. AF is traditionally characterized by spatiotemporally disorganized electrical activation and, although initiating triggers for AF are described, it is unclear whether AF is sustained by spatially meandering continuous excitation (re-entrant waves), localized electrical sources within the atria, or some other mechanism. This has limited therapeutic options for this condition. Here we show that human AF is predominantly caused by a small number (1.8 ± 0.9) of localized re-entrant waves or repetitive focal beats, that remain stable with limited spatial migration over prolonged periods of time. Radiofrequency ablation that selectively targeted the sites of these sources was able to immediately terminate fibrillation and eliminate the arrhythmia with high success. Our results show that human AF, despite apparent spatiotemporal disorganization, is often perpetuated by a few spatially-constrained and temporally conserved sources whose targeted ablation can eliminate this complex rhythm disorder.
A new approach for in-vehicle camera traffic sign detection and recognition (2009)

In this paper we discuss theoretical foundations and a practical realization of a circular traffic sign detection and recognition system operating on board of a vehicle. To initially detect sign candidates in the scene, we utilize the circular Hough transform with an appropriate post-processing in the vote space. Track of an already established candidate is maintained using a function that encodes the relationship between a unique feature representation of the target object and the affine transinformation it is subject to. This function is learned on-the-fly via regression from random distortions applied to the last stable image of the sign. Finally, we adopt a novel AdaBoost algorithm to learn a sign similarity measure from example image pairs labeled either ¨sameör ¨different ¨. This enables construction of an efficient multi-class classifier. Prototype implementation has been evaluated on a video captured in crowded street scenes. Good detection and recognition performance was achieved for a 14 class problem which reveals a high potential of our approach.
Radical nitridation in multi-oxide process for 100 nm generation CMOS technology (2002)

We propose a new multi-oxide technology, which drastically improves the ratio of the drive current to the gate leakage current for both high-performance (HP) transistors and low-power (LP) transistors on the same die. The key technology is radical nitridation (Watanabe et al, Appl. Phys. Lett. vol. 76, p. 2940, 2000; Togo et al, VLSI Tech. Symp., p. 116, 2000) followed by multi-oxide formation. In addition, it is easier to integrate with conventional CMOS processes compared with high-k dielectrics. Only one additional step reduces equivalent oxide thickness (EOT) of the LP transistor by 0.3 nm, thereby improving the drive current (I/sub on/). It also suppresses the gate leakage current (I/sub g/) for HP transistors by two orders of magnitude without an increase of EOT. Each oxide thickness of the multi-oxide is scalable to support various system-on-a-chip (SoC) applications.
Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation (2014)

The mammalian intestine is colonized by beneficial commensal bacteria and is a site of infection by pathogens, including helminth parasites. Helminths induce potent immunomodulatory effects, but whether these effects are mediated by direct regulation of host immunity or indirectly through eliciting changes in the microbiota is unknown. We tested this in the context of virus-helminth coinfection. Helminth coinfection resulted in impaired antiviral immunity and was associated with changes in the microbiota and STAT6-dependent helminth-induced alternative activation of macrophages. Notably, helminth-induced impairment of antiviral immunity was evident in germ-free mice, but neutralization of Ym1, a chitinase-like molecule that is associated with alternatively activated macrophages, could partially restore antiviral immunity. These data indicate that helminth-induced immunomodulation occurs independently of changes in the microbiota but is dependent on Ym1.
Compnet: A New Scheme for Single Image Super Resolution Based on Deep Convolutional Neural Network (2018)

The features produced by the layers of a neural network become increasingly more sparse as the network gets deeper and consequently, the learning capability of the network is not further enhanced as the number of layers is increased. In this paper, a novel residual deep network, called CompNet, is proposed for the single image super resolution problem without an excessive increase in the network complexity. The idea behind the proposed network is to compose the residual signal that is more representative of the features produced by the different layers of the network and it is not as sparse. The proposed network is experimented on different benchmark datasets and is shown to outperform the state-of-the-art schemes designed to solve the super resolution problem.
Stretch-induced calcium sensitization of rat lymphatic smooth muscle (2003)

The relationships between smooth muscle calcium and isometric tension generation to spontaneous lymphatic pump activity and its modulation by stretch equivalent from 0 to approximately 6 cmH2O were investigated. Excised preparations of the rat thoracic duct were mounted on a wire myograph and loaded with the calcium-sensitive fluorochrome indo-1. Calcium-dependent fluorescence and isometric force were simultaneously recorded. The thoracic duct segments developed spontaneous rhythmic contractile activity. Each contraction was preceded by an increase in intracellular calcium. When the vessels were normalized and stabilized at a preload equal to 3 cmH2O, the peak generation in tension occurred 0.70 +/- 0.11 s after that of calcium. Incremental stretch enhanced the frequency of the phasic activity and amplitude of isometric force generation but not the basal calcium level or the amplitude of the calcium transient. These findings suggest that stretch enhances lymphatic pump activity by increasing the pacemaker activity and the calcium sensitivity of the contractile apparatus.
A transient array to increase the peak power delivered to a localized region in space: part I-theory and modeling (2002)

It is shown that an array of pulsed antennas (a transient array) can be used for providing a high concentration of electromagnetic energy into small regions. By controlling the timing of the pulses radiated from the individual elements, selected regions of space will see a coherent superposition of the radiated pulses forming "hot spots." The formation of "hot spots" is demonstrated by theoretical analysis. Using a highly damped sinusoid for the radiated pulse and dipole antenna elements, a contour plot of the peak electric field is determined for a linear array of six equally spaced sources. The impact of pulse-timing errors and the factors determining the size of the hot spot are also considered.
Nonadiabatic photodissociation process using an optical near field (2004)

We demonstrated the deposition of nanometric Zn dots using photodissociation with gas-phase diethylzinc and an optical near field under nonresonant conditions. To explain the experimental results, we proposed an exciton-phonon polariton model, and discuss the quantitative experimental dependence of the deposition rate on the optical power and photon energy based on photodissociation involving multiple-step excitation via molecular vibration modes. The physical basis of this process, which seems to violate the Franck-Condon principle, is the optically nonadiabatic excitation of the molecular vibration mode due to the steep spatial gradient of the optical near-field energy.
High-Speed Discrete Gaussian Sampler With Heterodyne Chaotic Laser Inputs (2017)

Considering the limited throughput of a true random number generator (TRNG), the time independence of speed in a real discrete Gaussian sampler design was usually sacrificed. By utilizing the broadband chaos from an optically injected semiconductor laser with heterodyning, we propose a laser-field-programmable gate array system which generates discrete Gaussian numbers with a time-invariant throughput of 35.7 and 7.8 MSPS on Zedboard for two ring learning with errors schemes. Applying the proposed compressed cumulative distribution table method, the throughput of the proposed architectures reaches up to 40 and 8.3 MSPS, which is the fastest amongst the existing architectures based on TRNG inputs.
Label-Free Biosensing With a Slot-Waveguide-Based Ring Resonator in Silicon on Insulator (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We present a slot-waveguide-based ring resonator in silicon on insulator (SOI) with a footprint of only <formula formulatype="inline"><tex Notation="TeX">$13\ \mu\hbox{m} \times 10\ \mu\hbox{m}$</tex></formula>, fabricated with optical lithography. Experiments show that it has 298 nm/RIU sensitivity and a detection limit of <formula formulatype="inline"><tex Notation="TeX">$4.2\cdot 10^{-5}\ \hbox{RIU}$</tex></formula> for changes in the refractive index of the top cladding. We prove for the first time that surface chemistry for selective label-free sensing of proteins can be applied inside a 100 nm-wide slot region and demonstrate that the application of a slot waveguide instead of a normal waveguide increases the sensitivity of an SOI ring resonator with a factor 3.5 for the detection of proteins. </para>
In die Ferne schweifen (2012)

<b>Als Hospitantin in einem OP in Schweden</b> – Schweden gilt als das Paradies im Gesundheitswesen und ruft positive, fast schwärmerische Assoziationen unter Pflegenden hervor. Schwedische Pflegekräfte gelten als zufriedener, obwohl sie mehr Verantwortung tragen als deutsche. Doch entspricht das alles wirklich der Realität? Von dieser Frage inspiriert, fasste eine leitende Anästhesiepflegerin aus Coesfeld den Entschluss, sich selbst ein Bild vom schwedischen Gesundheitswesen zu machen.
Advances in Microwave on Chemical Reactions (2014)

Microwave is a part of the electromagnetic spectrum occurring in the frequency between infrared and radio waves. More and more attention to microwave has been paid, due to its magic effects in chemical reactions. The special electromagnetic field effect and the special heating way of mi- crowave make chemical reactions system be heated quickly and uniformly and bring necessary changes in molecular energy levels. Microwave makes chemical reactions become more and more high-speed, low-energy-costing, high-efficiency, green and environment-protective. In this review, the applications of microwave in chemical reactions are summarized, including the applications in organic synthesis, preparations of inorganic materials and catalytic materials and applications in environmental pollution control. In addition, subsistent problems in microwave chemistry are al- so systematically discussed and the possible developing orientations in the field of microwave ef- fects on the chemical reactions are also prospected. Progress of microwave applications for syn- thesizing of nano-materials and catalytic materials, removal of NOx and SO2 and treatment of wastewater are reviewed. Microwave provides a new direction and new powers for chemical reac- tion, which possesses wide applications in accelerating or changing chemical reaction. In the fu- ture, researches will be focused on the mechanisms of microwave chemistry, establishing the basis of microwave chemistry and improving the systematical theories of microwave chemistry. De- signing and creating of microwave chemical reactor device for industrial applications are also ex- pected.
Functor-driven natural language generation with categorial-unification grammars (1990)

Article Free Access Share on Functor-driven natural language generation with categorial-unification grammars Authors: Dale Gerdemann University of Illinois, at Urbana-Champaign, Urbana, IL University of Illinois, at Urbana-Champaign, Urbana, ILView Profile , Erhard W. Hinrichs University of Illinois, at Urbana-Champaign, Urbana, IL University of Illinois, at Urbana-Champaign, Urbana, ILView Profile Authors Info & Claims COLING '90: Proceedings of the 13th conference on Computational linguistics - Volume 2August 1990 Pages 145–150https://doi.org/10.3115/997939.997964Online:20 August 1990Publication History 4citation180DownloadsMetricsTotal Citations4Total Downloads180Last 12 Months33Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
The amino terminus regulates binding to and activation of cGMP‐dependent protein kinase (1989)

The allosteric regulation of binding to and the activation of cGMP-dependent protein kinase (cGMP kinase) was studied under identical conditions at 30 degrees C using three forms of cGMP-kinase which differed in the amino-terminal segment, e.g. native cGMP kinase, phosphorylated cGMP kinase which contained 1.4 +/- 0.4 mol phosphate/subunit and constitutively active cGMP kinase which lacked the amino-terminal dimerization domain. These three enzyme forms have identical kinetic constants, e.g. number of cGMP-binding sites, Km values for MgATP and the heptapeptide kemptide, and Vmax values. In the native enzyme, MgATP decreases the affinity for binding site 1. This effect is abolished by 1 M NaCl. In contrast, high concentrations of Kemptide increase the affinity of binding site 2 about fivefold. Under the latter conditions, identical Kd values of 0.2 microM were obtained for sites 1 and 2. Salt, MgATP and Kemptide do not affect the binding kinetics of the phosphorylated or the constitutively active enzyme, suggesting that allosteric regulation depends solely on the presence of a native amino-terminal segment. Cyclic GMP activates the native enzyme at Ka values which are identical with the Kd values for both binding sites. The activation of cGMP-dependent protein kinase is noncooperative but the Ka value depends on the substrate peptide concentration. These results show that the activity of cGMP kinase is primarily regulated by conformational changes within the amino-terminal domain.
Leveraging multiple languages to improve statistical MT word alignments (2005)

We present a new multilingual statistical MT word alignment model based on a simple extension of the IBM and HMM models and a two-step alignment procedure. Preliminary results on a small hand-aligned subset of the Europarl corpus show a 7% relative improvement over a state of the art alignment model
Preparation of fluconazole buccal tablet and influence of formulation expedients on its properties. (2011)

The aim of present study was to prepare buccal tablets of fluconazole for oral candidiasis. The dosage forms were designed to release the drug above the minimum inhibitory concentration for prolonged period of time so as to reduce the frequency of administration and to overcome the side effects of systemic treatment. The buccal tablets were prepared by using Carbopol 71G and Noveon AA-1 by direct compression method. Microcrystalline cellulose was used as the filler and its effect was also studied. The prepared dosage forms were evaluated for physicochemical properties, in vitro release studies and mucoadhesive properties using sheep buccal mucosa as a model tissue. Tablets containing 50% of polymers (Carbopol & Noveon) were found to be the best with moderate swelling along with favorable bioadhesion force, residence time and in vitro drug release. The in vitro drug release studies revealed that drug released for 8 h, which in turn may reduce dosing frequency and improved patient compliance in oral candidiasis patients.
The Interface Between Academic Knowledge and Working Knowledge: Implications for Curriculum Design and Pedagogic Practice. (2008)

This paper considers some aspects of the theory and practice of work-based learning (WBL) that may be of interest to academic staff in higher education who have responsibility for negotiating, designing, delivering and assessing programmes for, and with, Irish workplaces, companies, organisations and sectors of the workforce. The paper does not claim to be breaking significant new ground: rather it is trying to connect aspects of the field to inform underpinning of WBL curriculum design and related pedagogic practice as the start of a conversation rather than the last word.
ChemInform Abstract: REACTIONS OF SODIUM SILICATE WITH KAOLIN UNDER VARIOUS HYDROTHERMAL CONDITIONS (1977)

Abstract Röntgen‐, elektronenmikroskopische und IR‐Untersuchungen der Produkte der Reaktionen zwischen Natronwasserglas (Molverhältnis SiO, /Na,O = 3,8) und Kaolin bei hydrothermaler Behandlung in gesättigtem H, O‐Dampf im Autoklaven zeigen, daß Na‐silicat mit Kaolin bis zum Alumosilicagel bzw. bis zum kristallisierten Zeolith‐ Mineral Analcim Na,O′Al 2 O 3 ‐4 SiO, ‐2 H 2 O reagiert.
Kilohertz linewidth from frequency-stabilized mid-infrared quantum cascade lasers (1999)

Frequency stabilization of mid-IR quantum cascade (QC) lasers to the kilohertz level has been accomplished by use of electronic servo techniques. With this active feedback, an 8.5-microm QC distributed-feedback laser is locked to the side of a rovibrational resonance of nitrous oxide (N(2) O) at 1176.61cm (-1) . A stabilized frequency-noise spectral density of 42Hz/ radicalHz has been measured at 100 kHz; the calculated laser linewidth is 12 kHz.