gebhart/patrepeval huggingface dataset:
ACETYLATED FATTY ACID TOPICAL CREAM WITH MENTHOL REDUCES PAIN AND IMPROVES FUNCTIONAL PERFORMANCE IN INDIVIDUALS WITH ARTHRITIS (2005)

This investigation was an extension of a previous study conducted in our laboratory in which we showed that 1 month of treatment with a topical cream (Celadrint) consisting of cetylated fatty acids was effective for reducing pain and improving functional performance in individuals with osteoarthritis (OA) of the knee (Kraemer et al., Journal of Rheumatology, 2004). We wanted to verify that the addition of menthol to the compound would produce a similar percentage of improvement in therapeutic effects. We used a single treatment group with a pre-post experimental design to examine % treatment changes. Individuals diagnosed with OA of the knee (N = 10; age, 66.4 ± 11.5 years) and severe pain (e.g., OA, rheumatoid arthritis) of the elbow (N = 8; age, 59.1 ± 18.2 years) and wrist (N = 10; age, 60.3 ± 16.8 years) were tested for pain and functional performance before and after 1 week of treatment with a topical cream consisting of cetylated fatty acids and menthol applied twice per day. In individuals with knee OA, significant improvements in stair-climbing ability (about 12%), “up-and-go‘” performance (about 12%), balance and strength (about 16.5%), and range of motion (about 3.5%) were observed, as were reductions in pain. In individuals with severe pain of the elbow and wrist, significant improvements in dynamic (about 22 and 24.5%, respectively) and isometric (about 33 and 42%, respectively) local muscular endurance were observed, as was a reduction in pain. Neither group demonstrated significant changes in maximal grip strength or maximal force production. One week of treatment with a topical cream consisting of cetylated fatty acids and menthol was similarly effective for reducing pain and improving functional performance in individuals with arthritis of the knee, elbow, and wrist. The % changes were consistent with our prior work on the compound without menthol. Further work is needed to determine the impact of menthol in such a cream. Nevertheless, our data support the use of a topical cream consisting of cetylated fatty acids (with or without menthol) for enhancing the potential for exercise training in this population.
The effect of pH and modified maize starches on texture, rheological properties and meltability of acid casein processed cheese analogues (2016)

The objective of this study was to investigate the influence of pH on texture, rheological properties and meltability of processed cheese analogues obtained using acid casein (AC) at 11, 12 or 13 % concentration or using 10 % AC with 1, 2 or 3 % acetylated distarch adipate (ADA) or hydroxypropyl distarch phosphate (HDP). Hardness, adhesiveness, cohesiveness and viscosity increased with protein or starch concentration. The increase in complex viscosity (η*) was greater for samples contained ADA than HDP. In general, starch-containing cheese analogues exhibited more viscous properties (tan δ > 1) in higher pH values (6.0–7.0) and more elastic properties (tan δ < 1) in lower pH values (4.5–5.5). All processed cheese analogues obtained at pH 5.0–7.0 presented good melting characteristics. These various characteristics analysed in the present study may ensure the valuable information for obtaining cheeses with proper textural/rheological properties and meltability.
A low-power differential common-gate LNA (2008)

The conventional common-gate low-noise amplifier (CGLNA) exhibits a relatively high noise figure (NF) at low operating frequencies relative to the MOSFET f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> , which has limited its adoption even though its superior linearity, input matching, and stability compared to the inductively degenerated (CS-LNA). The design of a low-power inductorless LNA using a capacitive cross-coupled (CCC) g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> -boosting and a positive feedback schemes is described that improves the NF and retains the advantages of the CGLNA. The LNA designed in 0.13 mum CMOS shows more than 15 dB input return loss, maximum gain of 18.2 dB, NF of 2.86 dB, and the third-order input intercept point (IIP3) is 2 dB while dissipating 1.8 mA from 1.2 V supply.
Superconductivity and electrical properties in single-crystalline ultrathin Nb films grown by molecular-beam epitaxy (1995)

High-quality superconducting ultrathin Nb films were grown on sapphire single-crystal substrates by molecular-beam epitaxy, of which thicknesses ranged from 1.2 to 9.0 nm. They were found to be single crystalline by reflection high-energy electron diffraction. Size effects appeared remarkably in the normal conduction range. Superconducting transition temperatures (${\mathit{T}}_{\mathit{c}}$'s) of these films were higher than in the past reports for the same thicknesses. The thickness (d) dependence of ${\mathit{T}}_{\mathit{c}}$ was ln[${\mathit{T}}_{\mathit{c}}$(d)]\ensuremath{\propto}-1/d, which could be explained in terms of the proximity effect. A theory of localization effects in two-dimensional superconductors by Maekawa and Fukuyama, on the other hand, could not be applied to the present experiments, since the prepared ultrathin films had better crystallinity than those discussed in the theory.
Data-Driven Multiresolution Camera Using the Foveal Adaptive Pyramid (2016)

There exist image processing applications, such as tracking or pattern recognition, that are not necessarily precise enough to maintain the same resolution across the whole image sensor. In fact, they must only keep it as high as possible in a relatively small region, but covering a wide field of view. This is the aim of foveal vision systems. Briefly, they propose to sense a large field of view at a spatially-variant resolution: one relatively small region, the fovea, is mapped at a high resolution, while the rest of the image is captured at a lower resolution. In these systems, this fovea must be moved, from one region of interest to another one, to scan a visual scene. It is interesting that the part of the scene that is covered by the fovea should not be merely spatial, but closely related to perceptual objects. Segmentation and attention are then intimately tied together: while the segmentation process is responsible for extracting perceptively-coherent entities from the scene (proto-objects), attention can guide segmentation. From this loop, the concept of foveal attention arises. This work proposes a hardware system for mapping a uniformly-sampled sensor to a space-variant one. Furthermore, this mapping is tied with a software-based, foveal attention mechanism that takes as input the stream of generated foveal images. The whole hardware/software architecture has been designed to be embedded within an all programmable system on chip (AP SoC). Our results show the flexibility of the data port for exchanging information between the mapping and attention parts of the architecture and the good performance rates of the mapping procedure. Experimental evaluation also demonstrates that the segmentation method and the attention model provide results comparable to other more computationally-expensive algorithms.
pH Electrode -Based Enzyme Immunoassay for the Determination of Human Chorionic Gonadotropin (1982)

Abstract The determinazione of HCG is performed by the enzyme immunoassay technique using acetylcholinesterase enzyme as lable and a pH electrode to follow the enzyme activity. The antibody to HCG is immobilized in a membrane form with a polyethylene net; to the sample a certain amount of enzyme-labeled HCG is added, the antibody bound membrane is dipped for two hours; after it is taken out, washed and immersed in an acetylcholine Solution and a pH variation can be detected by placing a glass pH electrode with flat surface against the memberane for a few minutes. the pH variation is related tio the HCG concentration of the sample. Key Words: PotentiometryFnzyme ImmunoAssayHuman Chorionic gonadotropin
PR Program Boosts Public Image (1986)

This article discusses public perceptions of water and wastewater departments and the need for public relations efforts to increase public support for these important services. Examples of successful public relations programs are presented.
Traffic Signal Control with Connected Vehicles (2013)

The operation of traffic signals is currently limited by the data available from traditional point sensors. Point detectors can provide only limited vehicle information at a fixed location. The most advanced adaptive control strategies are often not implemented in the field because of their operational complexity and high-resolution detection requirements. However, a new initiative known as connected vehicles allows the wireless transmission of the positions, headings, and speeds of vehicles for use by the traffic controller. A new traffic control algorithm, the predictive microscopic simulation algorithm, which uses these new, more robust data, was developed. The decentralized, fully adaptive traffic control algorithm uses a rolling-horizon strategy in which the phasing is chosen to optimize an objective function over a 15-s period in the future. The objective function uses either delay only or a combination of delay, stops, and decelerations. To measure the objective function, the algorithm uses a microscopic simulation driven by present vehicle positions, headings, and speeds. The algorithm is relatively simple, does not require point detectors or signal-to-signal communication, and is completely responsive to immediate vehicle demands. To ensure drivers' privacy, the algorithm does not store individual or aggregate vehicle locations. Results from a simulation showed that the algorithm maintained or improved performance compared with that of a state-of-the-practice coordinated actuated timing plan optimized by Synchro at low and midlevel volumes, but that performance worsened under saturated and oversaturated conditions. Testing also showed that the algorithm had improved performance during periods of unexpected high demand and the ability to respond automatically to year-to-year growth without retiming.
<title>Statistical signal processing using wavelet-domain hidden Markov models</title> (1997)

Most wavelet-based statistical signal and image processing techniques treat the wavelet coefficients as though they were statistically independent. This assumption is unrealistic; considering the statistical dependencies between wavelet coefficients can yield substantial performance improvements. In this paper, we develop a new framework for wavelet-based signal processing that employs hidden Markov models to characterize the dependencies between wavelet coefficients.
Ketamine Metabolites Enantioselectively Decrease Intracellular D-Serine Concentrations in PC-12 Cells (2016)

D-Serine is an endogenous NMDA receptor co-agonist that activates synaptic NMDA receptors modulating neuronal networks in the cerebral cortex and plays a key role in long-term potentiation of synaptic transmission. D-serine is associated with NMDA receptor neurotoxicity and neurodegeneration and elevated D-serine concentrations have been associated with Alzheimer's and Parkinsons' diseases and amyotrophic lateral sclerosis. Previous studies have demonstrated that the ketamine metabolites (rac)-dehydronorketamine and (2S,6S)-hydroxynorketamine decrease intracellular D-serine concentrations in a concentration dependent manner in PC-12 cells. In the current study, PC-12 cells were incubated with a series of ketamine metabolites and the IC50 values associated with attenuated intracellular D-serine concentrations were determined. The results demonstrate that structural and stereochemical features of the studied compounds contribute to the magnitude of the inhibitory effect with (2S,6S)-hydroxynorketamine and (2R,6R)-hydroxynorketamine displaying the most potent inhibition with IC50 values of 0.18 ± 0.04 nM and 0.68 ± 0.09 nM. The data was utilized to construct a preliminary 3D-QSAR/pharmacophore model for use in the design of new and more efficient modulators of D-serine.
Mechanism of Asymmetric Production of <scp>l</scp>-Aromatic Amino Acids from the Corresponding Hydantoins by <i>Flavobacterium</i> sp. (1987)

Journal Article Mechanism of Asymmetric Production of l-Aromatic Amino Acids from the Corresponding Hydantoins by Flavobacterium sp. Get access Kenzo Yokozeki, Kenzo Yokozeki Central Research Laboratories of Ajinomoto Co., Inc., 1–1, Suzuki-cho, Kawasaki-ku, Kawasaki 210, Japan Search for other works by this author on: Oxford Academic Google Scholar Yoshiteru Hirose, Yoshiteru Hirose Central Research Laboratories of Ajinomoto Co., Inc., 1–1, Suzuki-cho, Kawasaki-ku, Kawasaki 210, Japan Search for other works by this author on: Oxford Academic Google Scholar Koji Kubota Koji Kubota Central Research Laboratories of Ajinomoto Co., Inc., 1–1, Suzuki-cho, Kawasaki-ku, Kawasaki 210, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 51, Issue 3, 1 March 1987, Pages 737–746, https://doi.org/10.1080/00021369.1987.10868116 Published: 01 March 1987 Article history Received: 26 August 1986 Published: 01 March 1987
Über Metalladditionen an mehrfache Bindungen (1914)

Die Arbeiten iiber die Metallketyle haben gezeigt, daB die C a rb o n y l g r u p p e , also die Kohlenstoff-Sauerstoff-Doppelbindung, gegentiber A l k a l i m eta11 ein betrachtliches A d d i t i o n s v e r m iigen besitzt.Diese uberraschende Erlahrung regte uns zu einer PruIung der Frage an, ob nicht auch die verschiedenen nndren Systeme mehrfacher Bindungen zu Zhnlichen Metalladditionen befahigt sind.Dabei hat sich gezeigt, daB unter entsprechenden Arbeitsbedingungen und bei Wahl der geeigneten Reprlsentanten der einzelnen Arten von Doppelbindungen es tatsiichlich gelingt, in den verschiedensten Fallen mittels Alkalimetalls eine Absattigung des ungeskttigten Zustandes herbeizuf iihren.Wenn auch die Zahl der fur eine solche Untersuchung in Frage kommenden Arten mehrfacher Bindungen eine relativ geringe ist, SO bedarf man wegen des groBen Einflusses, welchen die Natur der a n ungesattigte Gruppen geknupften Reste ganz allgemein auf die Additionsfahigkeit der mehrfachen Bindungen ausubt, doch eines grol3en experimentellen Materials, urn vollkommene Klarheit in die Verhaltnisse bei den Metalladditionen zu bringen.D a unser Material aber noch sehr liickenhaft ist, so
A transplantable TH‐MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastoma (2013)

Current multimodal treatments for patients with neuroblastoma (NBL), including anti-disialoganglioside (GD2) monoclonal antibody (mAb) based immunotherapy, result in a favorable outcome in around only half of the patients with advanced disease. To improve this, novel immunocombinational strategies need to be developed and tested in autologous preclinical NBL models. A genetically well-explored autologous mouse model for NBL is the TH-MYCN model. However, the immunobiology of the TH-MYCN model remains largely unexplored. We developed a mouse model using a transplantable TH-MYCN cell line in syngeneic C57Bl/6 mice and characterized the immunobiology of this model. In this report, we show the relevance and opportunities of this model to study immunotherapy for human NBL. Similar to human NBL cells, syngeneic TH-MYCN-derived 9464D cells endogenously express the tumor antigen GD2 and low levels of MHC Class I. The presence of the adaptive immune system had little or no influence on tumor growth, showing the low immunogenicity of the NBL cells. In contrast, depletion of NK1.1+ cells resulted in enhanced tumor outgrowth in both wild-type and Rag1(-/-) mice, showing an important role for NK cells in the natural anti-NBL immune response. Analysis of the tumor infiltrating leukocytes ex vivo revealed the presence of both tumor associated myeloid cells and T regulatory cells, thus mimicking human NBL tumors. Finally, anti-GD2 mAb mediated NBL therapy resulted in ADCC in vitro and delayed tumor outgrowth in vivo. We conclude that the transplantable TH-MYCN model represents a relevant model for the development of novel immunocombinatorial approaches for NBL patients.
Engineering Mechanosensitive Multivalent Receptor–Ligand Interactions: Why the Nanolinker Regions of Bacterial Adhesins Matter (2012)

Inspired by bacterial adhesins, we present a promising strategy of how to engineer peptides to probe various mechanical strains of extracellular matrix fibers. Functional sequence alignment of bacterial adhesins reveals that the bacterial linkers connecting the multivalent binding motifs recognizing fibronectin show considerable heterogeneity in length. Their length regulates the tunable affinities for fibronectin fibrils when stretched into different mechanical strain states. This platform has potential applications in probing extracellular matrix fiber strains in tissues.
Liver Regeneration Is Suppressed in Small-for-Size Liver Grafts after Transplantation: Involvement of c-Jun N-terminal Kinase, Cyclin D1, and Defective Energy Supply (2006)

Liver regeneration is stimulated in half-size grafts but suppressed in quarter-size grafts. Defective liver regeneration in small grafts is associated with an inhibition of the c-Jun N-terminal kinase/c-Jun and CyD1 pathways and compromised energy production.
Isotype‐specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation (2008)

Tumor cells express the glycolytic regulator pyruvate kinase subtype M2 (M2-PK), which can occur in a tetrameric form with high affinity to its substrate phosphoenolpyruvate (PEP) and a dimeric form with a low PEP affinity. The transition between both conformations contributes to the control of glycolysis and is important for tumor cell proliferation and survival. Here we targeted M2-PK by synthetic peptide aptamers, which specifically bind to M2-PK and shift the isoenzyme into its low affinity dimeric conformation. The aptamer-induced dimerization and inactivation of M2-PK led to a significant decrease in the PK mass-action ratio as well as ATP:ADP ratio in the target cells. Furthermore, the expression of M2-PK-binding peptide aptamers moderately reduced the growth of immortalized NIH3T3 cell populations by decelerating cell proliferation, but without affecting apoptotic cell death. Moreover, the M2-PK-binding peptide aptamers also reduced the proliferation rate of human U-2 OS osteosarcoma cells. In the present study, we developed the first specific inhibitors of the pyruvate kinase isoenzyme type M2 and present evidence that these inhibitors moderately decelerate tumor cell proliferation.
Micelle/Silica Co-protected Conjugated Polymer Nanoparticles for Two-Photon Excited Brain Vascular Imaging (2014)

Large two-photon absorption cross section and high fluorescence quantum yield (QY) of a fluorescent probe is highly desirable to achieve high resolution in two-photon excited fluorescence imaging. Taking poly(9,9-dihexylfluorene-alt-2,1,3-benzothiadiazole) (PFBT) as an example, we report a one-step approach to synthesize PFBT loaded nanoparticles (NPs) with both large two-photon absorption cross section and high fluorescence QY in aqueous media through a micelle and silica coprotection strategy. The PFBT loaded NPs show a two-photon absorption cross section of 1085 GM at 810 nm based on polymer chain concentration and an emission maximum at 545 nm with a high fluorescence QY of 75%. The fluorescence lifetime investigation reveals that the high fluorescence QY is mainly due to reduced polymer aggregation and minimized environment influence on conjugated polymer (CP) fluorescence quenching. The synthesized PFBT NPs have shown good colloid stability and photostability as well as benign biocompatibility, which have been further applied to visualize the mouse brain vasculature through intravital two-photon excited brain vascular imaging with high contrast. The developed micelle/silica coprotection strategy should be generally applicable to other CP NPs with improved brightness and stability for various biological applications.
Centralized control of carrier sense threshold and channel bandwidth in high-density WLANs (2014)

Wireless LAN (WLAN) devices are now everywhere and their rapid spread has created dense deployment environments. Since WLAN transmission is based on carrier sense multiple access with collision avoidance (CSMA/CA), network capacity is degraded by the restrictions created by CSMA/CA on transmission opportunity in such high-density WLAN environments. The increased channel bandwidth available in recent WLANs also accelerates the degradation in transmission opportunity. This paper proposes a centralized control scheme of carrier sense threshold and channel bandwidth to improve spectrum efficiency in high-density WLAN environments. The proposed control determines the clear channel assessment (CCA) threshold and channel bandwidth by using the received signal strength indicator (RSSI) and wireless channel information of the access points (APs). A computer simulation shows that the proposed control raises the average throughput per station by 15 times compared to the conventional isolated APs.
The Efficacy and Safety of Intravenous Emulsified Isoflurane in Rats (2005)

Although direct IV injection of liquid volatile anesthetics is usually lethal, anesthesia using emulsified halothane and isoflurane without adverse effects has been safely induced in animals. We identified the safe concentration of emulsified volatile anesthetic preparations and determined the dose-response relationship of IV emulsified isoflurane and propofol in rats. Liquid/gas partition coefficients of desflurane, sevoflurane, isoflurane, enflurane, and halothane in 20% and 30% Intralipid were measured and used to calculate their saturated concentrations. Unsaturated emulsified isoflurane was prepared by adding liquid isoflurane to 30% Intralipid. The loss of forepaw righting reflex was taken as induction of anesthesia, and disappearance of electrocardiogram was taken as death. The median effective induction dose (ED50) and median lethal dose (LD50) of emulsified isoflurane were 0.072 and 0.216 mL/kg liquid isoflurane, respectively. The ED50 and LD50 of propofol were 5.89 mg/kg and 18.19 mg/kg, respectively. Time to return of forepaw righting reflex after injection of emulsified isoflurane (38 +/- 18 s) was significantly shorter than with propofol (101 +/- 62 s; P < 0.05). Anesthesia was successfully induced in rats by IV emulsified isoflurane with a comparable safety index and certain safety factor as propofol. Recovery of anesthesia after IV emulsified isoflurane was faster than with propofol.
Optimization of grid design for solar cells (2010)

By theoretical simulation of two grid patterns that are often used in concentrator solar cells, we give a detailed and comprehensive analysis of the influence of the metal grid dimension and various losses directly associated with it during optimization of grid design. Furthermore, we also perform the simulation under different concentrator factors, making the optimization of the front contact grid for solar cells complete.
Image patterned molecular delivery into live cells using gold particle coated substrates (2010)

An image-patterned molecular delivery system for mammalian cells is demonstrated by pulsed laser irradiation of gold particles immobilized on a substrate below a cell monolayer. Patterned cavitation bubble nucleation was captured using a time-resolved imaging system and molecular delivery verified by observing the uptake of a membrane-impermeable fluorescent dye, calcein. Delivery efficiency as high as 90% was observed and multiplexed, patterned dye delivery was demonstrated.