gebhart/patrepeval huggingface dataset:
Enteric solid dispersion of ciclosporin A (CiA) having potential to deliver CiA into lymphatics. (1989)

Solid dispersions composed of three components, ciclosporin A (CiA), surfactant (HCO-60) and a pharmaceutical additive, were prepared. As an additive, cellulose acetate phthalate (CAP), methacrylic acid and methacrylic acid methylester copolymer (Eudragit L-100) and hydroxypropylmethylcellulose phthalate (HP-55), which are generally used as enteric coating materials, were employed. The dissolution behavior of CiA from these enteric solid-dispersion system was studied according to the paddle method of JP XI in comparison with that of Sandimmun, an olive oily CiA solution as a reference. Solid dispersion of CiA preparation did not dissolve in the 1st test fluid (pH 1.2) in 2 h. In the 2nd fluid (pH 6.8), about 80% of CiA was dissolved within 12 min, though the dissolution rate was dependent on both the quality and quantity of the additives. An in vivo systemic and lymphatic availability study was performed with rats whose carotid artery and thoracic lymph duct were cannulated. After intrastomach administration of each CiA preparation to rats at a dose of 7 mg/kg, blood and lymph samples were collected for 6 h. One of the HP-55 preparations gave the highest plasma CiA level, Cmax = 0.99 +/- 0.20 (S.E., n = 4) micrograms/ml, and also showed the highest lymphatic availability, the percentage of dose delivered to the lymphatics in 6 h was 1.98 +/- 0.10% and the maximum lymph CiA level was 76.8 +/- 12.86 micrograms/ml. Lymphatic availability of CiA from Sandimmun was 0.78 +/- 0.11% and the peak plasma CiA level was 0.46 +/- 0.10 microgram/ml.(ABSTRACT TRUNCATED AT 250 WORDS)
Quadrifilar helix antenna for MIMO system (2004)

In this letter, the performance of using a meander line printed quadrifilar helix antenna (MPQHA) structure in a multiple-input-multiple-output (MIMO) system was investigated. It is known that MIMO systems can offer larger capacity than traditional systems, and can exploit transmit or receive diversity. An important parameter is the correlation between the adjacent channels, with a capacity increase for low correlation. It was found that the MPQHA offers low correlation between its individual elements, and has significant advantages in terms of size compared to an array of monopole antennas.
Barometric whole body plethysmography in mice (2005)

There has been significant utilization of the technique described by Hamelmann et al. ( Am J Respir Crit Care Med 156: 766–775, 1997) in which a parameter, enhanced pause (Penh), related to airways responsiveness is noninvasively measured by unrestrained plethysmography (UP). Investigating this technique, we sought to answer these questions: 1) How do changes in Penh compare with changes in traditional plethysmographic and lung mechanical parameters? 2) How do UP parameters perform in two different mouse strains? Awake immunized and control BALB/c ( n = 16) and C57BL/6 ( n = 14) mice were placed in the UP chamber and exposed to doses of aerosolized methacholine while the following parameters were measured at each concentration: inspiratory time (Ti), expiratory time (Te), total time (Ttot), Ti/Ttot, peak inspiratory pressure, peak expiratory pressure, Pause, Penh, tidal volume (Vt), Vt/Ti, Vt/Te, and Vt/Ttot. The next day, lung resistance (Rl) and compliance (Cl) were invasively measured in the same animals. For the BALB/c, the parameters with the highest magnitude of correlation coefficient vs. Rl are (in order) 1) Cl, 2) Pause and Penh, 3) parameters of breathing frequency (Te, Ttot, Ti), and 4) parameters related to Vt (inspiratory pressure, expiratory pressure). Flow parameters (Vt/Ttot, Vt/Te, Vt/Ti) and duty cycle parameters (Ti/Ttot) had insignificant correlations. This ordering is significantly different in C57BL/6 mice, in which the parameters with the largest correlations are 1) Cl, 2) parameters of breathing frequency, and 3) flow parameters. Pause, Penh, Vt, and duty cycle parameters had insignificant correlations. These data show that Penh is problematic in the sense that it is strain specific; it behaves very differently in BALB/c and C57BL/6 mice. We suggest that UP parameters largely originate as part of reflex control of breathing processes, rather than in the lung mechanics and conclude that it is inappropriate to use UP parameters in general, and Penh specifically, as substitute variables for invasive mechanical indexes such as Rl.
Perceived Time as a Measure of Mental Workload: Effects of Time Constraints and Task Success (2012)

The mental workload imposed by systems is important to their operation and usability. Consequently, researchers and practitioners need reliable, valid, and easy-to-administer methods for measuring mental workload. The ratio of perceived time to clock time appears to be such a method, yet mental workload has multiple dimensions of which the perceived time ratio has mainly been linked to the task-related dimension. This study investigates how the perceived time ratio is affected by time constraints, which make time an explicit concern in the execution of tasks, and task success, which is a performance-related rather than task-related dimension of mental workload. A higher perceived time ratio is found for timed than untimed tasks. According to subjective workload ratings and pupil-diameter measurements, the timed tasks impose higher mental workload. This finding contradicts the prospective paradigm, which asserts that perceived time decreases with increasing mental workload. A higher perceived time ratio was also found for solved than unsolved tasks, whereas subjective workload ratings indicate lower mental workload for the solved tasks. This finding shows that the relationship between the perceived time ratio and mental workload is reversed for task success compared to time constraints. Implications for the use of perceived time as a measure of mental workload are discussed.
The development of the automatic lane following navigation system for the intelligent robotic wheelchair (2011)

In this paper, we constructed an intelligent robotic wheelchair equipped with automatic tracking function in barrier-free environment of campus; the system used video paint line detection as the basis of automatic tracking navigation; since the barrier-free environment of campus includes indoor and outdoor environment and the outdoor environment includes gentle slopes, sidewalk and etc, we proposed a paint line detection method, which showed color distribution and judgment of paint line using Gaussian mixture models; the input image completed paint line detection and parameters calculation with this method and then input them into the fuzzy logic controller of wheelchair and in this way, the tracking navigation control of wheelchair was performed; the system was actually tested on barrier-free paths in campus, including straight and curve barrier-free paths; the result showed that the system could make the wheelchair keep moving on the paint line correctly and the mean deviation was kept within ±10 cm, which proved the navigation of intelligent robotic wheelchair could be realized automatically and successfully on barrier-free paths in campus.
ChemInform Abstract: CYCLING CHARACTERISTICS OF SECONDARY LITHIUM ELECTRODE IN LITHIUM TETRAFLUOROBORATE (LIBF4)/MIXED ETHER ELECTROLYTES (1985)

Abstract Die Einflüsse der Stromdichte und der Elektrolytkonzentration auf die Ladungs‐Entladungs‐Ausb. von Li‐Elektroden in 1,3‐Dioxolan(DOL)‐TH F/ LiBE‐Lösungen werden untersucht und mit dem entsprechenden Verhalten bei Verwendung von 2‐Me‐DOL oder 2,2‐Me2‐DOL als Lösungsmittel neben THF verglichen.
The effect of scandium on the tissue distribution of Ga-67 in normal and tumor-bearing rodents. (1980)

In rats and mice the intravenous administration of scandium before or with Ga-67 produces an increase in Ga-67 excretion and bone deposition, coupled with pronounced decreases in the uptake of Ga-67 in soft tissues. These effects result from the blocking by scandium of Ga-67 plasma-protein binding sites, which forces Ga-67 into an unbound or loosely bound state. This increases Ga-67 excretion and bone deposition, which in turn acts to produce greatly reduced Ga-67 uptake in soft tissues. When tumor-bearing rats and mice are administered scandium, similar effects occur, but the uptake of Ga-67 by tumor tissue remains unchanged. This suggests that Ga-67 enters tumor and normal soft tissues by different routes. With tumor, an unbound or loosely bound form of gallium is primarily involved, whereas with normal soft tissues this route is apparently of minor importance.
Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein. (1994)

The myristoylated alanine-rich C kinase substrate (MARCKS) and the MARCKS-related protein (MRP) are members of a distinct family of protein kinase C (PKC) substrates that also bind calmodulin in a manner regulated by phosphorylation by PKC. The kinetics of PKC-mediated phosphorylation and the calmodulin binding properties of intact, recombinant MARCKS and MRP were investigated and compared with previous studies of synthetic peptides spanning the PKC phosphorylation site/calmodulin binding domains (PSCBD) of these proteins. Both MARCKS and MRP were high affinity substrates for the catalytic fragment of PKC, and their phosphorylation occurred with positive cooperativity (MARCKS: S0.5 = 100 nM, KH = 1.43; MRP: S0.5 = 238 nM, KH = 1.72). These affinities are similar to the values determined from studies of their respective PSCBD peptides. Two-dimensional mapping of MRP and its synthetic PSCBD peptide yielded identical patterns of tryptic phosphopeptides, indicating that, as in the case of MARCKS, all of the PKC phosphorylation sites in MRP lie within the 24-amino acid PSCBD. Sequence analysis of tryptic phosphopeptides revealed that the first and third, but not the second, serines in the MRP PSCBD were phosphorylated by PKC. Both MARCKS and MRP bound dansyl-calmodulin with high affinity, with a Kapp of 4.6 and 9.5 nM, respectively. Phosphorylation of MARCKS and MRP by PKC disrupted the protein-calmodulin complexes, with half-lives of 4.0 and 3.5 min, respectively. These studies suggest that intact, recombinant MARCKS and MRP are accurately modeled by their synthetic PSCBD peptides with respect to PKC phosphorylation kinetics and their phosphorylation-dependent calmodulin binding properties.
Weight-Oriented Approximation for Energy-Efficient Neural Network Inference Accelerators (2020)

Current research in the area of Neural Networks (NN) has resulted in performance advancements for a variety of complex problems. Especially, embedded system applications rely more and more on the utilization of convolutional NNs to provide services such as image/audio classification and object detection. The core arithmetic computation performed during NN inference is the multiply-accumulate (MAC) operation. In order to meet tighter and tighter throughput constraints, NN accelerators integrate thousands of MAC units resulting in a significant increase in power consumption. Approximate computing is established as a design alternative to improve the efficiency of computing systems by trading computational accuracy for high energy savings. In this work, we bring approximate computing principles and NN inference together by designing NN specific approximate multipliers that feature multiple accuracy levels at run-time. We propose a time-efficient automated framework for mapping the NN weights to the accuracy levels of the approximate reconfigurable accelerator. The proposed weight-oriented approximation mapping is able to satisfy tight accuracy loss thresholds, while significantly reducing energy consumption without any need for intensive NN retraining. Our approach is evaluated against several NNs demonstrating that it delivers high energy savings (17.8% on average) with a minimal loss in inference accuracy (0.5%).
<title>Three-dimensional correlation of MR images to muscle tissue response for interventional MRI thermal ablation</title> (2001)

We are treating tumors using radiofrequency (RF) ablation under interventional MRI (iMRI) guidance. We investigated the ability of MR to monitor the treated region by comparing MR thermal lesion images to cellular damage as seen histologically. Our new methodology allows 3D registration that should enable more accurate correlation than previous 2D methods. Using a low-field (0.2T) open magnet iMRI system for probe guidance, we applied RF ablation to the thigh muscle of four New Zealand White rabbits. To relate in vivo MR and histology images, we obtained intermediate ex vivo MR images and pictures of thick tissue slices obtained using a specially designed apparatus. Registration was done with a computer algorithm that matches tracks of needle fiducials placed near the tissue of interest. After registration, we determined the region inside the circular, hyperintense rim in MR closely corresponds to the region of necrosis as determined by histology on animals sacrificed 30 minutes after ablation. This is good evidence that iMRI images can be used for real-time feedback during thermal RF ablation treatments.
α-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats (2003)

Total gene expression analysis (TOGA) was used to identify genes that are differentially expressed in brain regions between the alcohol-naive, inbred alcohol-preferring (iP), and -nonpreferring (iNP) rats. alpha-Synuclein, expressed at >2-fold higher levels in the hippocampus of the iP than the iNP rat, was prioritized for further study. In situ hybridization was used to determine specific brain regions and cells expressing alpha-synuclein in the iP and iNP rats. Similar to alpha-synuclein mRNA levels, protein levels in the hippocampus were higher in iP rats than iNP rats. Higher protein levels were also observed in the caudate putamen of iP rats compared with iNP rats. Sequence analysis identified two single nucleotide polymorphisms in the 3' UTR of the cDNA. The polymorphism was used to map the gene, by using recombination-based methods, to chromosome 4, within a quantitative trait locus for alcohol consumption that was identified in the iP and iNP rats. A nucleotide exchange in the iNP 3' UTR reduced expression of the luciferase reporter gene in SK-N-SH neuroblastoma cells. These results suggest that differential expression of the alpha-synuclein gene may contribute to alcohol preference in the iP rats.
[Acute myocardial infarct and Friedreich's disease]. (1995)

The association between Friedreich's ataxia and heart disease is well known. Microvascular disease and spasm of coronary arteries have been reported. We report now a patient with the association between this disease and acute myocardial infarction, which raises the hypothesis that it may be related with the already known cardiac abnormalities in this disease.
Mining for Useful Association Rules Using the ATMS (2006)

Association rule mining has made many achievements in the area of knowledge discovery in databases. Recent years, the quality of the extracted association rules has drawn more and more attention from researchers in data mining community. One big concern is with the size of the extracted rule set. Very often tens of thousands of association rules are extracted among which many are redundant thus useless. In this paper, we first analyze the redundancy problem in association rules and then propose a novel ATMS-based method for extracting non-redundant association rules
The effects of Qi-Qong ocular exercise on accommodation. (1995)

Visual-training methods in management of myopia are suggested as possibly leading to normal vision or an improvement in the refractive state. The purpose of this work was to investigate the hypothesis that a Qi-Qong ocular exercise improves visual function by training the accommodation bias. Variations of pupil size, accommodative amplitude, latency and speed of accommodative response and accommodative adaptation were evaluated objectively. The accommodative state was monitored with an objective infrared refractometer (Nidek AA-2000). Subjects were divided into two groups: experimental (n = 9), and control (n = 8). Subjects of the experimental group undertook the Qi-Qong ocular exercise for at least three years, and were able to perform the exercise smoothly and gently. Subjects of the control group had no knowledge of the Qi-Qong ocular exercise, but were given the same testing procedures as the experimental group. Results showed that Qi-Qong ocular exercise can improve the accommodative amplitude and accelerate the accommodative response slightly, but there was no effect on the latency of accommodative response. Furthermore, the level of accommodative adaptation was elevated, and the pupil became slight miotic. Therefore, the mechanism of visual improvement may undergo a great accommodative adaptation and produce a pinhole effect by miosis of the pupil. Methods of visual training can produce a false image of visual improvement from an enhanced parasympathetic response to a task, but this effect may be a factor that induces progression of myopia.
Cross-Media Alignment of Names and Faces (2009)

In this paper we report on our experiments on aligning names and faces as found in images and captions of online news Websites. Developing accurate technologies for linking names and faces is valuable when retrieving or mining information from multimedia collections. We perform exhaustive and systematic experiments exploiting the (a)symmetry between the visual and textual modalities. This leads to different schemes for assigning names to the faces, assigning faces to the names, and establishing name-face link pairs. On top of that, we investigate generic approaches to the use of textual and visual structural information to predict the presence of the corresponding entity in the other modality. The proposed methods are completely unsupervised and are inspired by methods for aligning phrases and words in texts of different languages developed for constructing dictionaries for machine translation. The results are competitive with state-of-the-art performance on the ¿Labeled Faces in the Wild¿ dataset in terms of recall values, now reported on the complete dataset, include excellent precision values, and show the value of text and image analysis for identifying the probability of being pictured or named in the alignment process.
Quantification of Pulsatility as a Function of Vascular Input Impedance: An In Vitro Study (2007)

The physiological benefits of pulsatility generated by ventricular assist device (VAD) support continue to be heavily debated as application of VAD support has been expanded to include destination and recovery therapies. In this study, the relationship between input impedance (Zart) and vascular pulsatility during continuous flow (CF) or pulsatile flow (PF) VAD support was investigated. Hemodynamic waveforms were recorded at baseline failure and with 50%, 75%, and 100% CF or PF VAD support for nine different Zart test conditions (combination of three different resistance and compliance settings) in a mock circulatory system simulating left ventricular failure. High-fidelity hemodynamic pressure and flow waveforms were recorded to calculate mean arterial pressure (MAP), Zart, energy equivalent pressure (EEP), and surplus hemodynamic energy (SHE) as metrics for quantifying vascular pulsatility. MAP and EEP were elevated with increasing resistance whereas SHE was reduced with increasing compliance. Vascular pulsatility was restored with increasing PF VAD support, but diminished by up to 90% with increasing CF VAD support. The nonpulsatile energy component (MAP) of the pressure waveform is dependent on resistance whereas the pulsatile energy component (SHE) is dependent on compliance. The impact of Zart and vascular pulsatility on patient recovery with VAD support warrants further investigation.
A sample cell for low temperature optical absorption studies of frozen aqueous solutions (1974)

A sample cell for optical absorption studies of frozen aqueous solutions from 68 to 300 K is described. The use of very thin samples reduces undesirable scattering and the cell design permits both vacuum sealing to ∼ 10−6 Torr and the elimination of optical window breakage.
A review of metal oxynitrides for photocatalysis (2016)

This review highlights the recent progress in the production of hydrogen using a metal oxynitride photocatalyst under visible light irradiation.
Driver confusion status detection using recurrent neural networks (2016)

In this paper, we present a method for estimating the confusion level of a driver using a classifier trained on multimodal sensor data. Using the driver confusion status detector, a car navigation system can proactively support the driver when he/she is confused. A corpus of data was collected during on-road driving in traffic using a navigation system and a car instrumented with a variety of sensors. The data was manually annotated with the driver's confusion status and with multiple features representing driver's behavior and the traffic conditions. We compared different types of classifiers trained from the data: logistic regression, a feed-forward neural network, a recurrent neural networks, and a long short-term memory (LSTM)-based recurrent neural network. The accuracy was evaluated using F-max as well as precision/recall. We found that the LSTM outperformed the other models.
Tritiation of the cannabinoid receptor antagonist SR144528 involving lithium aluminum tritide reduction; assessment of the kinetic isotope effect by <sup>3</sup>H‐NMR (2005)

Abstract The cannabinoid receptor antagonist SR144528 was synthesized by an approach that enabled the incorporation of high specific activity tritium label while circumventing the lability of the target compound to catalytic hydrogenation. Lithium aluminum tritide of less than maximum specific activity was employed to introduce tritium, resulting in an H/T incorporation indicative of no kinetic isotope effect for the hydride/tritide reduction of a methyl benzoate. Copyright © 2005 John Wiley & Sons, Ltd.
Bistatic SAR ATR (2007)

With the present revival of interest in bistatic radar systems, research in that area has gained momentum. Given some of the strategic advantages for a bistatic configuration, and technological advances in the past few years, large-scale implementation of the bistatic systems is a scope for the near future. If the bistatic systems are to replace the monostatic systems (at least partially), then all the existing usages of a monostatic system should be manageable in a bistatic system. A detailed investigation of the possibilities of an automatic target recognition (ATR) facility in a bistatic radar system is presented. Because of the lack of data, experiments were carried out on simulated data. Still, the results are positive and make a positive case for the introduction of the bistatic configuration. First, it was found that, contrary to the popular expectation that the bistatic ATR performance might be substantially worse than the monostatic ATR performance, the bistatic ATR performed fairly well (though not better than the monostatic ATR). Second, the ATR performance does not deteriorate substantially with increasing bistatic angle. Last, the polarimetric data from bistatic scattering were found to have distinct information, contrary to expert opinions. Along with these results, suggestions were also made about how to stabilise the bistatic-ATR performance with changing bistatic angle. Finally, a new fast and robust ATR algorithm (developed in the present work) has been presented.