gebhart/patrepeval huggingface dataset:
Efficacy of Flocculating and Other Emergency Water Purification Tablets (1993)

Abstract : Chlor-Floc (CF) emergency water purification tablets were tested for bactericidal, viricidal and cysticical efficacy; removal of turbidity and chemical agents in water at temperatures ranging from 5 deg C-to 25 deg C; and storage stability at 5, 25 and 40 deg C. The minimal required reduction was achieved for bacteria, Rotavirus, and Giardia, bu CF did not achieve the required reduction of Poliovirus at any of the temperatures or time periods investigated. Clarification of water was effective in turbid waters, but filtration through a cloth is necessary to prevent flocculated sediment from entering the canteen. Removal of chemical agents from water was a function of the solubility of the chemical agent, the rate of hydrolysis and the composition of the water. The free residual chlorine in CF tablets remained stable at 5 deg C-and 25 deg C for 27 months, but declined rapidly after three months at 40 0 C and three days at 60 deg C. To be acceptable to the Military, the tablets must be approved and registered by the EPA and must be stable during normal storage for three years. Commercial Item Descriptions have been written for CF tablets and for a kit containing tablets, filters, and a water treatment bag. Both may be procured through the Defense General Supply Center, Richmond, VA.... Water purification, Chlorine flocculating tablets, Water purification kit, Bactericidal tests, Iodine tablets, Water treatment, Chlor-Floc (CF), Tablets.
Coronary vascular sympathetic beta-receptor innervation (1976)

Recent studies indicate that coronary vessels have alpha- and beta-2-adrenergic receptors and that the alpha receptors are functionally innervated. We studied whether the beta-2-vasodilator receptors are functionally innervated, using a dog in situ modified Langendorff preparation with constant coronary perfusion pressure. The beating, nonworking heart and systemic circulation were supported with a pump oxygenator. Stimulation of the left stellate ganglion increased coronary blood flow and decreased coronary sinus oxygen tension from prestimulation control values. After beta-1-receptor blockade (practolol, 10 mg/kg), stellate stimulation decreased coronary blood flow and decreased coronary sinus oxygen tension from prestimulation control values, revealing alpha-receptor vasoconstriction. After the addition of alpha-receptor blockade (Dibozane, 5 mg/kg), stellate stimulation increased coronary blood flow and coronary sinus oxygen tension a small amount from prestimulation values. Finally, after the addition of beta-2-receptor blockade (propranolol, 2 mg/kg), stellate stimulation increased flow and coronary sinus oxygen tension slightly from prestimulation control values. Direct intracoronary injections of isoproterenol, norepinephrine, and epinephrine gave results consistent with the presence of beta-1 myocardial receptors and alpha and beta-2 coronary receptors. We conclude that there is little functional innervation of coronary vascular beta-2 receptors. Intracoronary injections of isoproterenol and epinephrine activated beta-2-receptor coronary vasodilation after beta-1-receptor blockade, but norepinephrine did not.
Pharmacological effects of N-[2-[[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]ethyl]hyaluronamide (diclofenac Etalhyaluronate, SI-613), a novel sodium hyaluronate derivative chemically linked with diclofenac (2018)

A single IA injection of SI-613 was shown to exert analgesic and anti-inflammatory effects for 28 days in non-clinical pharmacological studies, suggesting that SI-613 will be a promising candidate in the treatment of osteoarthritis pain.
Targeting the <scp>N</scp>otch signaling pathway in cancer therapeutics (2014)

Despite advances in surgery, imaging, chemotherapy, and radiotherapy, the poor overall cancer-related death rate remains unacceptable. Novel therapeutic strategies are desperately needed. Nowadays, targeted therapy has become the most promising therapy and a welcome asset to the cancer therapeutic arena. There is a large body of evidence demonstrating that the Notch signaling pathway is critically involved in the pathobiology of a variety of malignancies. In this review, we provide an overview of emerging data, highlight the mechanism of the Notch signaling pathway in the development of a wide range of cancers, and summarize recent progress in therapeutic targeting of the Notch signaling pathway.
Planar miniature tapered-slot-fed annular slot antennas for ultrawide-band radios (2005)

A novel planar tapered-slot-fed annular slot antenna is proposed in this paper. The antenna utilizes a unique tapered-slot feeding structure and simultaneously possesses ultrawide bandwidth, almost uniform radiation patterns, and low profile. It is, hence, adequate for ultrawide-band (UWB) applications. By means of a normalized antenna transfer function, both frequency domain and time domain characteristics of the antenna are carefully investigated. Two measures, the uniformity related to the radiation patterns and the fidelity associated with the transient behaviors, are used to quantitatively describe the performance of an antenna over such an ultrawide bandwidth. Effects of varying the antenna's geometric parameters on the performance are then investigated. Finally, the influence of minimizing the antenna dimension is discussed at the end of the paper.
Inertial Navigation - Forty Years of Evolution (1998)

For over forty years, this Company has been one of the world’s significant players in the field of iner tial navigation. From its inception, as an almost impossible, barelyaffordable technology for guiding strategic missiles, to today’s acceptance of it as an everyday fact of life, the art and craft of iner tial navigation still retains some of its mystique, and continues to provide stretching challenges in engineering. This article doesn’t pretend to be a textbook-there are plenty of excellent and readable texts available (see, for example, refs. (13)). This paper will attempt to explain only what is necessary in order to understand the significance of the current and future trends.
Polarizing Filters in Ski Sports (2010)

Abstract Polarizing filters are suitable, e.g., for driving/motoring. They also have great advantages for sailing or angling. But are they useful in alpine skiing? A natural source for at least partly polarized light is not only the scattered light in the sky but also the reflected light on special materials. The reflected light on snow might be partly polarized, especially for compressed snow (traces in the snow) or ice patches. Depending on the direction of the polarization of a filter, the amount of information might be reduced in a skiing area because these polarized icy patches might become invisible.
C-myc deregulation during transformation induction: involvement of 7SK RNA (1997)

The process of oncogenic transformation has been widely studied but is still poorly understood. We have focused on the mechanism of deregulation of the c-myc gene during transformation of a temperature-sensitive SV40-transformed mouse cell line. Run-on transcription assays showed that the two c-myc minor promoters, P1 and P3, are transiently activated following induction of transformation and that peak activation of both promoters is preceded by a large increase in transcription of a small RNA (7SK). To test the possibility that this RNA might participate in promoter activation, we transfected cells with sense and antisense oligodeoxynucleotides corresponding to different regions of the 7SK RNA predicted to be accessible within the RNP particle. Out of 14 oligos tested, inhibition of activation of P1 and/or P3 was observed with four antisense oligonucleotides corresponding to looped regions in the putative 7SK secondary structure. To identify c-myc promoter sequences which might serve as targets for 7SK activity, we carried out mobility-shift assays with either whole or 7SK-depleted cell extracts. The CT element of the c-myc promoter formed a 7SK-dependent complex which could be competed only with the same antisense 7SK oligo that suppressed P1 and P3 activation in vivo. Taken together these results suggest that 7SK RNP participates in transformation-dependent c-myc deregulation.
Considerations of noise and schemes for its reduction in laser amplifiers (1964)

Spontaneous emission adds noise to the signal in laser amplifiers. In this paper the radiation characteristics of this noise and structures to reduce it are discussed. The structures make use of the spatial directionality of coherent light, and consist of aperture stops in combination with lenses. Their ultimate performance is studied. Signal-beam configurations necessary for optimum signal-to-noise (SNR) are described.
Aminomercuration of olefins (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAminomercuration of olefinsH. K. Hall Jr., J. P. Schaefer, and R. J. SpanggordCite this: J. Org. Chem. 1972, 37, 20, 3069–3075Publication Date (Print):October 1, 1972Publication History Published online1 May 2002Published inissue 1 October 1972https://pubs.acs.org/doi/10.1021/jo00985a006https://doi.org/10.1021/jo00985a006research-articleACS PublicationsRequest reuse permissionsArticle Views165Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vitamin D and prostate cancer: a prediagnostic study with stored sera. (1993)

This study evaluates the risk of prostate cancer in relation to serum levels of the major vitamin D metabolites, 25-hydroxyvitamin D (25-D3) and 1,25-dihydroxyvitamin D (1,25-D). Between 1964 and 1971, more than 250,000 serum samples were collected from members of the Kaiser Permanente Medical Care Plan in Oakland and San Francisco and stored for future use. Levels of 25-D and 1,25-D were measured in samples from 90 black and 91 white men diagnosed with prostate cancer before December 31, 1987 and controls individually matched on age, race, and day of serum storage. Mean serum 1,25-D was 1.81 pg/ml lower in cases than in matched controls (P = 0.002). Risk of prostate cancer decreased with higher levels of 1,25-D especially in men with low levels of 25-D. However, mean 25-D was not significantly different in cases and controls. The association of lower 1,25-D with prostate cancer was found in men above the median age of 57 years at serum storage but not younger men and was similar in black and white men. In men > or = 57 years of age, 1,25-D was an important predictor of risk for palpable and anaplastic tumors but not for tumors incidentally discovered during surgery to treat the symptoms of benign prostatic hyperplasia or well differentiated tumors.
Behavior Based Adaptive Control for Autonomous Oceanographic Sampling (2007)

This paper describes an investigation into the adaptive control of autonomous mobile sensor platforms for providing oceanographic sampling. Mobile sensor platforms provide an ability to rapidly sample oceanographic data of interest for real-time input into ocean environmental models with the goal of reducing the modeling uncertainty by introducing selected sampled data. The major objective of this paper is to describe the autonomy architecture developed to support adaptive sampling. This architecture consists of an open-source distributed autonomy architecture and an approach to behavior-based control of autonomous vehicles using multiple objective functions that allows reactive control in complex environments with multiple constraints. Experimental results are provided for an adaptive ocean thermal gradient tracking application performed by an autonomous surface craft in Monterey Bay. These results highlight not only the suitability of autonomous sensor platforms for providing adaptive sampling of the ocean environment but, also, the suitability of our behavior-based autonomy approach and distributed autonomy architecture for providing a simple, flexible, and scalable method for autonomous sensor platform control. The paper concludes with an overview of future adaptive sampling experiments planned with autonomous underwater sensor platforms using the same methodology.
Stereoselective Prostereogenic 3‐Oxo Ester Reduction Mediated by a Novel Yeast Alcohol Dehydrogenase Derived from <i>Kluyveromyces marxianus</i> CBS 6556 (2007)

Abstract A yeast alcohol dehydrogenase (ADH) has been purified up to a purification factor value of 21,731‐fold from Kluyveromyces marxianus CBS 6556. The purification procedure consisted of two chromatographic steps (DEAE‐anion exchange and affinity chromatography). The optimal pH was 7, its optimal temperature was 40 °C and its co‐factor was NADPH. This novel ADH efficiently mediated the reduction of 3‐oxo esters with a high degree of stereoselectivity, providing chiral alcohols having the ( S ) absolute configuration at the newly formed stereogenic centre by delivering the hydride from the re ‐face of the prochiral carbonyl compounds.
Enterotoxemia in rabbits. (1978)

The presence of Clostridium perfringens Type E iota toxin was confirmed from the cecal contents of 23 of 46 rabbits which died of enteritis complex. The most consistent lesions observed were hemorrhage and edema in the cecum. Rabbit toxicity tests showed the toxic cecal contents were lethal for young rabbits unless incubated with Clostridium perfringens Type E antiserum.
The Making of a Gaming-Simulation Course: A Personal Tale (2004)

The author’s gaming-simulation course atWestern Carolina University has been 30 years in the making. Its structure, content, and instructional methods are heavily influenced by the author’s professorial aspirations and experience in the use of simulations. In this brief article, the author shares some of his early use of educational games and gaming simulations, his creation of a graduate-level course on the design and use of gaming simulations, and how he has updated his course for the digital age. For readers who are thinking about creating a gaming-simulation course of their own, the author has listed some common simulation course development barriers and a few strategies for overcoming them.
A Human Monoclonal IgG1λ Anti‐Hepatitis B Surface Antibody (1985)

Peripheral blood mononuclear cells from a donor with a high titre of anti-hepatitis B surface (HBs) antibodies were fused with a cell line that was positive for Epstein-Barr virus nuclear antigen and sensitive to hypoxanthine-aminopterine-thymidine. A cell line was established that produces a monoclonal IgG1 lambda anti-HBs antibody. Afterwards, it appeared that the anti-HBs antibody-producing cell line had arisen from Epstein-Barr virus transformation of the donor B cells. The cell line is capable of producing up to 60 micrograms/ml of the monoclonal antibody, which has a high avidity for HBs antigen (Ag) and recognizes both ad and ay subtypes. The antibody is useful as a reagent for the detection of HBsAg in human serum. Over 1000 patient sera have been tested with a conventional third-generation assay in parallel, and only a single discrepant serum was found.
Influence of vaccination on respiratory coccidiodial disease in cynomolgous monkeys. (1962)

Five of ten Cynomolgous monkeys (Macaca irus) died and two were moribund within 9 months after respiratory infection with 200 coccidioidal arthrospores. None of seven animals previously vaccinated with formalinized spheruleendospore elements of the fungus succumbed to the above dose but one vaccinated animal challenged with approximately 400 arthrospores died within a 7-week period. It was demonstrated that both early and late roentgenographic changes in the lungs were less extensive in the vaccinated group than in the control group and these observations were in accord with pathologic findings at necopsy. The etiologic agent was recovered from the lungs of all surviving animals but histopathologic studies suggested that the parasite was contained more effectively within lesions in the vaccinated monkeys.
Thermodynamics of nematic phases formed from semiflexible chain polymers (1978)

Abstract In co[poly(ethylene terephthalate)‐p‐oxybenzoate] containing 30 mole % oxybenzoate units, the ethylene terephthate units crystallize. The copolymer melts in the temperature range 180–210°C to form a nematic phase which, at a higher temperature, transforms to an isotropic liquid. The latent heat of the first transition is 5 cal/g, and the thermodynamic melting temperature, 247°C, is essentially that expected for a random copolymer of this composition. The nematic → isotropic transition occurs at 244°C, with an enthalpy change of 3.2 cal/g (10% of the heat of fusion of poly(ethylene terephthalate)). We conclude that semiflexible polymers form a nematic phase which is rather highly disordered. The model of the nematic phase treated by Flory is modified to increase its entropy through incorporation of chain bends (which must be correlated in position and direction with those in neighboring molecules). This increases the chain extension, as measured by the fraction (1– f ) of collinear chain bonds, required to form the nematic phase. For binary polymer‐solvent systems, an appropriate scaling of f values leaves the phase diagram as predicted by Flory's treatment essentially unchanged.
S100A9 a new marker for monocytic human myeloid‐derived suppressor cells (2012)

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of cells that negatively regulate the immune response during tumour progression, inflammation and infection. Only limited data are available on human MDSC because of the lack of specific markers. We have identified members of the S100 protein family-S100A8, S100A9 and S100A12 - specifically expressed in CD14(+) HLA-DR(-/low) MDSC. S100A9 staining in combination with anti-CD14 could be used to identify MDSC in whole blood from patients with colon cancer. An increase in the population of CD14(+) S100A9(high) MDSC was observed in the peripheral blood from colon cancer patients in comparison with healthy controls. Finally, nitric oxide synthase expression, a hallmark of MDSC, was induced in CD14(+) S100A9(high) upon lipopolysaccharide/interferon-γ stimulation. We propose S100 proteins as useful markers for the analysis and further characterization of human MDSC.
RECENT ADVANCES IN PHARMACEUTICAL CHEMISTRY–REVIEW III A NEW WAVE OF BETA-BLOCKERS (1987)

In the U.K. today there are 11 8-blockers, as well as approximately 52 different formulations or trademarks including combination products, in various strengths; this does not take into account the generic products also available. World-wide there are more than 30 different 8-blockersY although propranolol is still the most widely used and is believed to account for over a third of the World market. Atenolol and metoprolol are the two next most popular. These 8-blockers, available today, are used primarily in hypertension and angina although some are registered for use to control arrhythmias, thyrotoxicosis and migraine. The most recent new 8-blocker to the U.K. market is betaxolol (trademark Kerlone) launched in September 1984. Despite this large number there is a new wave of 8-blocking compounds nearing completion of research and development. At present over 40 8-blockers are currently in development world-wide with over one-third of these close to a market launch. This review will look closely at some of the new products now awaiting registration or in Phase I11 clinical trials in addition to the most recent entry to the U.K. market, betaxolol, and assess their place amongst existing 8-blockers.
Octadecylthiol-modified surface-enhanced Raman spectroscopy substrates: a new method for the detection of aromatic compounds (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOctadecylthiol-modified surface-enhanced Raman spectroscopy substrates: a new method for the detection of aromatic compoundsKeith Carron, Laura Peitersen, and Mary LewisCite this: Environ. Sci. Technol. 1992, 26, 10, 1950–1954Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/es00034a011https://doi.org/10.1021/es00034a011research-articleACS PublicationsRequest reuse permissionsArticle Views445Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Localization of Living-Bodies Using Single-Frequency Multistatic Doppler Radar System (2009)

Recently, it has become important to rapidly detect human subjects buried under collapsed houses, rubble and soil due to earthquakes and avalanches to reduce the casualties in a disaster. Such detection systems have already been developed as one kind of microwave displacement sensors that are based on phase difference generated by the motion of the subject's breast. Because almost all the systems consist of single transmitter and receiver pair, it is difficult to rapidly scan a wide area. In this paper, we propose a single-frequency multistatic radar system to detect breathing human subjects which exist in the area surrounded by the transmitting and receiving array. The vibrating targets can be localized by the MUSIC algorithm with the complex amplitude in the Doppler frequency. This algorithm is validated by the simulated signals synthesized with a rigorous solution of a dielectric spherical target model. We show experimental 3D localization results using a developed multistatic Doppler radar system around 250MHz.