gebhart/patrepeval huggingface dataset:
Expression of Escherichia coli SecB in Bacillus subtilis facilitates secretion of the SecB-dependent maltose-binding protein of E. coli (1994)

Less than 20% of the Escherichia coli maltose-binding protein (MBP) synthesized in Bacillus subtilis is exported. However, a portion of the secreted MBP was processed cotranslationally. Coexpression of SecB, a secretion-related chaperone of E. coli, stimulated posttranslational export of MBP in B. subtilis but inhibited its cotranslational processing. Export of a SecB-independent MBP-ribose-binding protein hybrid precursor was not enhanced by SecB. A slowly folding MBP derivative (MBP-Y283D) was more efficiently secreted than wild-type MBP, suggesting that the antifolding activity of SecB promotes posttranslational secretion of MBP in B. subtilis.
Preliminary characterization of Thy-1.1 and Ag-B antigens from rat tissues solubilized in detergents (1974)

1. A radioactive binding assay for Thy-1.1 alloantigen which functions in the presence of detergents was established by using glutaraldehyde-fixed thymocytes as target cells. Thy-1.1 activity in detergent extracts was then assayed by measuring inhibition of the binding assay. 2. Solubilization of Thy-1.1 from whole thymocytes, and their membranes by a large number of non-ionic detergents and deoxycholate was studied. In the same extracts Ag-B(4) histocompatibility antigenic activities were measured. With the exception of Nonidet P-40, the detergents did not affect the antigenicity of Thy-1.1, but only Lubrol-PX and deoxycholate gave effective solubilization as measured by activity remaining in the supernatant after centrifugation at 200000g for 40min. With Ag-B(4) antigen, Triton X-100, Triton X-67 and Nonidet P-40 gave effective solubilization as well as Lubrol-PX and deoxycholate. Solubilization of Thy-1.1 activity from leukaemia cells and a brain homogenate was also studied, but none of the non-ionic detergents gave satisfactory results with these tissues. 3. Extracts from thymocyte membranes were further examined by gel filtration and sucrose gradient centrifugation. The Thy-1.1 activity behaved as a single component in deoxycholate with a density similar to that of a globular protein, but in Lubrol-PX the antigen was contained in a low-density complex. In Lubrol-PX extracts Ag-B(4) was also found in aggregates not observed in deoxycholate. 4. The s(20,w) values for Thy-1.1 and Ag-B(4) antigens in deoxycholate were 2.4 and 4.4, and v values were 0.70 and 0.75 respectively. The Stokes radius observed for Thy-1.1 was 3.1nm and for Ag-B(4) 5.3nm. By using these values the molecular weights for the antigen-detergent complexes were calculated to be 28000 for Thy-1.1 and 100000 for Ag-B(4).
Assessment of Frequency Selective Surface for Improving Indoor Cellular Coverage (2014)

Modern houses use energy efficient building materials like metal shielding and energy saving windows to improve the thermal efficiency. Such energy efficient building mate-rials creates the barrier for outdoor-to-indoor RF signals propagation which is one of the challenging problems in the field of cellular communication. In order to solve such problem of outdoor-to-indoor propagation, an effective and efficient solution is very essential. Some existing techniques to solve the indoor coverage problem are the use of outdoor to indoor repeaters, pico-cell or dedicated indoor systems like distributed an-tenna system and radiating cables. However, such techniques are operator oriented; ex-pensive for single residential houses; possess additional network architecture design and maintenance complexity. One of the newer passive techniques which is operator inde-pendent and does not have additional network burden, is the use of frequency selective windows. Frequency selective windows consist of Frequency Selective Surface (FSS) etched on the metal coating of the energy saving windows, allowing cellular frequencies to pass through them while blocking the thermal radiation. FSS is the combination of either conducting patches or apertures in a thin conducting sheet arranged periodically in one or two dimensional array. FSS possess frequency selective behavior based on the element geometry. Patch type of FSS exhibits total reflection around resonant frequency whereas aperture type exhibits total transmission. \nThis thesis presents the modelling, simulation, fabrication and test measurements of the FSS that is transparent to GSM and UMTS frequency band. FSS with a double square loop aperture as a unit cell is selected for the analysis. The modelling and simu-lation of the FSS are carried out in the Computer Simulation Technology (CST) micro-wave studio, 2012 version. FSS prototype is fabricated using the commercial available aluminum foil. Furthermore, the FSS prototype is tested in the laboratory as well as in real-time networks. The real-time or field measurement is conducted in the real networks for all three operators of Finland, namely DNA, Elisa and TeliaSonera. The laboratory result shows the resonant frequency shift downwards by a factor of 1.22 comparing to the simulation results of freestanding FSS. The reason behind such frequency shift is well explained by the presence of a dielectric substrate in FSS prototype. On average, for all operators the field measurement result shows the transmission improvement of around 10 dB and 4.5 dB in GSM and UMTS band respectively over the plain aluminum foil. Although the field measurement result does not show much improvement compared to the laboratory measurement result, it still prevails the possibility of using FSS for indoor coverage improvement.
Determination of Ungrafted Rubber in Abs Polymers (1974)

A method has been developed for determining the amount of ungrafted rubber in ABS polymers. First the styrene-acrylonitrile (SAN) resin is removed by extraction with ethyl acetate. The composition of the SAN resin was determined by NMR analysis. The ethyl acetate insoluble material which consists of graft polymer and ungrafted rubber is then extracted with a mixture of hexachlorobutadiene and ethyl acetate The ungrafted rubber dissolves in the extraction solvent mixture while the graft polymer remains insoluble Filtration, concentration of the filtrate by vacuum distillation and NMR analysis of the concentrated filtrate using an internal standard technique provided the amount and composition of the ungrafted rubber. The data also permitted the amount and composition of the graft polymer to be calculated.
Switched reluctance machines for EV and HEV propulsion: State-of-the-art (2013)

This paper overviews the state of the art of switched reluctance machines (SRM) and their potential application in propulsion of electric vehicles (EV) and hybrid electric vehicles (HEV). Three-phase SRM configurations have been advised, in order to reduce the inverter cost, and a relationship between their numbers of stator-poles and rotor-poles have been established. Compared to other machine technologies, SRMs produce more high frequency pure tones (up to 12 kHz) that are prominent and perceived as unpleasant. The poor sound quality of SRMs is holding them from a possible consideration for mass-production in automotive applications.
Effect of 12 Months of Whole-Body Vibration Therapy on Bone Density and Structure in Postmenopausal Women (2011)

Whole-body vibration therapy at 0.3g and 90 or 30 Hz for 12 months did not alter BMD or bone structure in postmenopausal women who received calcium and vitamin D supplementation.
Pneumolysin Causes Neuronal Cell Death through Mitochondrial Damage (2007)

Bacterial toxins such as pneumolysin are key mediators of cytotoxicity in infections. Pneumolysin is a pore-forming toxin released by Streptococcus pneumoniae, the major cause of bacterial meningitis. We found that pneumolysin is the pneumococcal factor that accounts for the cell death pathways induced by live bacteria in primary neurons. The pore-forming activity of pneumolysin is essential for the induction of mitochondrial damage and apoptosis. Pneumolysin colocalized with mitochondrial membranes, altered the mitochondrial membrane potential, and caused the release of apoptosis-inducing factor and cell death. Pneumolysin induced neuronal apoptosis without activating caspase-1, -3, or -8. Wild-type pneumococci also induced apoptosis without activation of caspase-3, whereas pneumolysin-negative pneumococci activated caspase-3 through the release of bacterial hydrogen peroxide. Pneumolysin caused upregulation of X-chromosome-linked inhibitor of apoptosis protein and inhibited staurosporine-induced caspase activation, suggesting the presence of actively suppressive mechanisms on caspases. In conclusion, our results indicate additional functions of pneumolysin as a mitochondrial toxin and as a determinant of caspase-independent apoptosis. Considering this, blocking of pneumolysin may be a promising cytoprotective strategy in pneumococcal meningitis and other infections.
Human coagluation factor V purification and thrombin-catalyzed activation. (1980)

Factor V was isolated from human plasma by barium citrate adsorption, polyethylene glycol fractionation, DEAE-Sepharose CL-6B chromatography, ammonium sulfate fractionation, and gel chromatography on Ultrogel 22. Degradation of Factor V during purification was largely prevented by ample use of inhibitors of proteolytic enzyme. The purified Factor V was a stable, single-chain molecule with an apparent molecular weight of 330,000. Activation of human Factor V by thrombin resulted in a 10- to 15-fold increase in activity. The activation pattern as monitored by sodium dodecyl sulfate polyacrylamide gel electrophoresis was compared with that of bovine Factor V. Differences in the patterns of thrombin activation were noticed between the two species, whereas the final products were similar. The products of human Factor V activation are two closely spaced doublets, one with an apparent molecular weight of approximately 110,000, and the other, approximately 72,000. An antibody was raised against the purified protein. Crossed immunoelectrophoresis showed that the antibody recognized Factor V both before and after activation with thrombin.
Where special means sinister (1993)

(1993). Where special means sinister. The Journal of Forensic Psychiatry: Vol. 4, No. 1, pp. 5-8.
Comorbidity and Survival in Lung Cancer Patients (2015)

Future models for predicting lung cancer survival should take individual comorbid conditions into consideration.
Schutzschicht gegen Bakterien (2011)

Abstract Der unterschiedliche Aufbau der Membranen von eukaryontischen Zellen und von Bakterienzellen ist der Angriffspunkt für natürliche antibakterielle Peptide. Synthetische (Co)Polymere nutzen deren Strategie ebenfalls und schützen als Beschichtung medizinische Implantate gegen Bakterien.
Synthesizing Scene Text Images for Recognition with Style Transfer (2019)

Majority of the existing datasets for tasks like scene text recognition only include a few thousand images with a very limited words and characters. Therefore, it cannot meet the need of the typical deep learning based text recognition approaches. In the same time, although the standard synthetic datasets usually comprise millions of scene text images, which means that the data distribution of the small target datasets cannot be learned very well. We propose a word image generating method called Synth-Text Transfer Network to solve these problems. It has the capability of estimating and simulating the distribution of target datasets. Synth-Text Transfer Network utilizes a style transfer approach to synthesis images with arbitrary text content with preserving the texture of the referenced style image in the target dataset. The large amount of synthesized images can help to alleviate the overfitting problem and improve the accuracy in latter scene text image recognition tasks. In addition, our proposed method is flexible and fast, which has a relatively fast speed among regular style transfer approaches.
Fast gaze typing with an adjustable dwell time (2009)

Previous research shows that text entry by gaze using dwell time is slow, about 5-10 words per minute (wpm). These results are based on experiments with novices using a constant dwell time, typically between 450 and 1000 ms. We conducted a longitudinal study to find out how fast novices learn to type by gaze using an adjustable dwell time. Our results show that the text entry rate increased from 6.9 wpm in the first session to 19.9 wpm in the tenth session. Correspondingly, the dwell time decreased from an average of 876 ms to 282 ms, and the error rates decreased from 1.28% to .36%. The achieved typing speed of nearly 20 wpm is comparable with the result of 17.3 wpm achieved in an earlier, similar study with Dasher.
A Review on Process Validation (2016)

Process validation is the process for improving the safety and quality of the dosage form which is manufactured in the pharmaceutical industry. Basically, Process validation emphasize the role of objective measure and statistical tools and analyses knowledge, detection, and control of variability and give assurance on consistent of quality / productive throughout life cycle of product. Result from Process validation method can be used to judge the quality and consistency of analytical result. The purpose of this review to cover need of process validation, principle of process validation, type of process validation, phase of process validation, strategy for process validation. In this review article we discussed about the importance and strategy of validation of analytical procedure.
Advances in Malignant Mesothelioma (2005)

Malignant mesothelioma is an aggressive tumor of serosal surfaces, such as the pleura and the peritoneum. This tumor was once rare, but its incidence is increasing worldwide, probably as a result of widespread exposure to asbestos, a factor with which it is associated. The authors review advances made in the past 5 to 10 years in the understanding, diagnosis, and management of mesothelioma.
Applying personal construct theory in occupational guidance (1979)

Abstract Personal construct theory was applied to various occupational choice problems. It became clear that there was no single best way of applying it, since the technique could easily be adapted to suit varying circumstances. Attempts to introduce it to occupational guidance officers have so far lead to only limited use, but it is hoped that modified training may increase their confidence in utilising it where appropriate.
Correlation of Hedgehog Signal Activation with Chemoradiotherapy Sensitivity and Survival in Esophageal Squamous Cell Carcinomas (2010)

These findings suggest an important role for the activation of hedgehog signaling in esophageal squamous cell carcinoma progression and that PTCH1 and GLI-1 expression may be significantly associated with esophageal squamous cell carcinoma resistance to chemoradiotherapy.
Microscopic identification of defects propagating through the center of silicon and indium-doped liquid encapsulated Czochralski grown GaAs using x-ray topography (1985)

Extended defects in 3×1018 cm−3 Si-doped and 2×1019 cm−3 In-doped GaAs grown by the liquid encapsulated Czochralski technique are investigated using x-ray topography and found to include straight and helicoidal dislocations propagating along the central axis of the ingot. These dislocations are not simply extensions of dislocations in the seed. The defect morphology is explained by strong interaction with native point defects and elastic strain associated with solute segregation at the growing interface.
Scanning Ellipsometric Spectroscopy: Study of the Formation of the Anodic Oxide Film on Noble Metals. (1973)

Abstract : The formation of the anodic oxide film on Pt has been investigated at wavelengths in the visible using voltage scanning ellipsometry. Changes in light intensity in an ellipsometric experiment were used to determine the changes in optical properties of the surface. From these three parameters, the effective complex refractive index and thickness of the surface film have been calculated, using a three-layer model. The anodic oxide film on Au has also been studied using this technique. (Modified author abstract)
Vertex-based anisotropic texturing (2001)

MIP mapping is a common method used by graphics hardware to avoid texture aliasing. In many situations, MIP mapping over-blurs in one direction to prevent aliasing in another. Anisotropic texturing reduces this blurring by allowing differing degrees of filtering in different directions, but is not as common in hardware due to the implementation complexity of current techniques. We present a new algorithm that enables anisotropic texturing on any current MIP map graphics hardware supporting MIP level biasing, available in OpenGL 1.2 or through the GL_EXT_texture_lod_bias or GL_SGIX_texture_lod_bias OpenGL extensions. The new algorithm computes anisotropic filter footprint parameters per vertex. It constructs the anisotropic filter out of several MIP map texturing passes or multi-texture lookups. Each lookup uses MIP level bias and perturbed texture coordinates to place one probe used to construct the more complex filter profile.
Effects of the Mechanical Properties of Polymer Resin and the Conductive Ball Types of Anisotropic Conductive Films on the Bending Properties of Chip-in-Flex Package (2016)

Ultrathin chip-in-flex (CIF) packages using anisotropic conductive film (ACF) as an interconnecting material were demonstrated as one of the flexible electronic packages for wearable electronics applications. In this paper, the effects of ACF resin material and conductive ball type on the CIF package bending properties were investigated. Various ACFs with different moduli were fabricated by adding silica particle to polymer resin. For the conductive ball type, solder ball, metal-coated polymer ball, and Ni ball were used. To quantify the bending properties of the CIF packages, dynamic bending test was performed. It was found that the lowest modulus resin (0.54 GPa) resulted early delamination between the conductive ball and the electrode interface. For the resin modulus of 1.04 GPa, the conductive balls and electrodes interface delamination was significantly suppressed due to lower deformation of ACFs. However, when the modulus was increased to 1.3 GPa, chip crack failure occurred presumably due to the internal stress increase at the chip area. Therefore, it is suggested that the optimal modulus of the ACF resin was around 1 GPa. In addition, among the various conductive ball types, metal-coated polymer balls showed no electrical and mechanical failure even after 160k dynamic bending cycles. The metal-coated polymer balls had better compliance compared with the solder ball and Ni ball, which eventually prevented chip crack and ACF contact loss to occur.
Switchable focus using a polymeric lenticular microlens array and a polarization rotator (2013)

We demonstrate a flat polymeric lenticular microlens array using a mixture of rod-like diacrylate monomer and positive dielectric anisotropy nematic liquid crystal (LC). To create gradient refractive index profile in one microlens, we generate fringing fields from a planar top electrode and two striped bottom electrodes. After UV stabilization, the film is optically anisotropic and can stand alone. We then laminate this film on a 90° twisted-nematic LC cell, which works as a dynamic polarization rotator. The static polymeric lenticular lens exhibits focusing effect only to the extraordinary ray, but no optical effect to the ordinary ray. Such an integrated lens system offers several advantages, such as low voltage, fast response time, and temperature insensitivity, and can be used for switchable 2D/3D displays.
Dual Mechanisms of ABCA1 Regulation by Geranylgeranyl Pyrophosphate (2001)

ATP-binding cassette transporter A1 (ABCA1) mediates an active efflux of cholesterol and phospholipids and is mutated in patients with Tangier disease. Expression of ABCA1 may be increased by certain oxysterols such as 22(R)-hydroxycholesterol via activation of the nuclear hormone receptor liver X receptor (LXR). In searching for potential modulators of ABCA1 expression, we have studied the effects of various mevalonate metabolites on the expression of ABCA1 in two human cell lines, THP-1 and Caco-2 cells. Most of the tested metabolites, including mevalonate, geranyl pyrophosphate, farnesyl pyrophosphate, and ubiquinone, failed to significantly change the expression levels of ABCA1. However, treatment with geranylgeranyl pyrophosphate resulted in a dose- and time-dependent reduction of ABCA1 expression. Geranylgeranyl pyrophosphate appears to reduce ABCA1 expression via two different mechanisms. One of these mechanisms is by acting directly as an antagonist of LXR since it reduces the interaction between LXR alpha or -beta with nuclear coactivator SRC-1. Another mechanism appears to involve activation of the Rho GTP-binding proteins since treatment of Caco-2 cells with inhibitors of geranylgeranyl transferase or the Rho proteins significantly increased the expression and promoter activity of ABCA1. Further studies showed that mutations in the DR4 element of the ABCA1 promoter completely eliminate the inducible activities of these inhibitors. These data indicate that activation of the Rho proteins may change the activation status of LXR.
Place-Based Environmental Health Justice Education: A Community-University-Government-Middle School Partnership (2012)

In collaboration with the Woonasquatucket River Watershed Council and the Department of Environmental Management, the Brown University Superfund Research Program's Community Engagement Core piloted an environmental health justice program with middle school students in Rhode Island. Our curriculum introduces students to environmental justice and the nearby Superfund site, with the goal of building environmental health justice literacy and encouraging civic engagement in local environmental remediation. Although little research has been done on teaching middle school students about environmental justice, popular education approaches rooted in community-based participatory research methods are regularly used in community outreach activities to organize and engage local residents in community issues. With this particular program, we present a place-based, student-centered, standards-aligned model for teaching environmental health justice.
Organische Phosphorverbindungen XVI. Reduktion von Phosphinsulfiden zu den entsprechenden dreiwertigen Phosphorverbindungen (1964)

Abstract The reduction of (C 6 H 5 ) 3 PS, ( p ‐CH 3 C 6 H 4 ) 3 PS and ( n ‐C 4 H 9 ) 3 PS with iron powder to the corresponding tertiary phosphines is described. Reduction of ( o ‐, p ‐ClC 6 H 4 ) 3 PS, ( i ‐C 4 H 9 ) 2 P(S)H, thiophosphonic as well as thiophosphinic halides with tributylphosphine to the corresponding trivalent phosphorus compounds is also reported.
Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in <i> Apc <sup>Min/+</sup> </i> mice (2005)

Leptin acts as a growth factor on colon cancer cells in vitro but does not promote tumour growth in vivo in the two models tested. These findings do not support a pivotal role for hyperleptinaemia in intestinal carcinogenesis.