gebhart/patrepeval huggingface dataset:
Target regulation of neuronal differentiation in a temperature-sensitive cell line derived from medullary raphe (1993)

Following infection of dissociated embryonic day 13 rat medullary raphe cells with a retrovirus encoding the temperature-sensitive mutant of SV40 large T antigen, a clonal cell line, RN33B, was isolated by serial dilution. At 33°C, RN33B cells divide with a doubling time of 48 h and show T antigen, vimentin, nestin, diffuse neuron-specific enolase, and low and medium molecular weight neurofilament immunoreactivities. RN33B cells are immortal, but not transformed, as they will not grow in soft agar. At non-permissive temperature (38°C), T antigen expression is markedly decreased and RN33B cells cease mitotic activity and differentiate with phase bright cell bodies and ‘neuritic-like’ processes. Differentiated RN33B cells express enhanced neuronal-spcific protein expression but do not synthesize astrocytic or oligodendrolytic-specific proteins. Moreover, differentiated RN33B cells returned to 33°C re-express T antigen, but do not de-differentiate or begin dividing. Co-culture with embryonic hippocampus and cerebral cortex, but not medullary raphe or spinal cord, resulted in significantly greater survival, more complex neuronal morphology, and enhanced expression of neuronal-specific antigens. Immunohistochemical and Northern blot analysis revealed high levels of low affinity NGF receptor protein and mRNA in differentiated RN33B cells. PCR analysis demonstrated the presence of trkB, but not trkA or trkC, mRNA in both undifferentiated and differentiated RN33B cells.These data sugest that the observed target regulation of RN33B cell neuronal differentiation in co-culture may be mediated by neurotrophin(s).
Bioelectronic neural pixel: Chemical stimulation and electrical sensing at the same site (2016)

Local control of neuronal activity is central to many therapeutic strategies aiming to treat neurological disorders. Arguably, the best solution would make use of endogenous highly localized and specialized regulatory mechanisms of neuronal activity, and an ideal therapeutic technology should sense activity and deliver endogenous molecules at the same site for the most efficient feedback regulation. Here, we address this challenge with an organic electronic multifunctional device that is capable of chemical stimulation and electrical sensing at the same site, at the single-cell scale. Conducting polymer electrodes recorded epileptiform discharges induced in mouse hippocampal preparation. The inhibitory neurotransmitter, γ-aminobutyric acid (GABA), was then actively delivered through the recording electrodes via organic electronic ion pump technology. GABA delivery stopped epileptiform activity, recorded simultaneously and colocally. This multifunctional "neural pixel" creates a range of opportunities, including implantable therapeutic devices with automated feedback, where locally recorded signals regulate local release of specific therapeutic agents.
A 5 Gb/s repeaterless transmission system using erbium-doped fiber amplifiers (1993)

A fully engineered 5 Gb/s repeaterless long-span transmission system with excellent long term performance is introduced. The transmitting power from an optical power booster was +15.5 dBm with SBS suppression, and an optical preamplifier receiver provided a receiver sensitivity of -38 dBm for 10/sup -9/ BER (or -35 dBm for 10/sup -15/ BER). A Ti:LiNbO/sub 3/ external modulator transmitter allowed dispersion limited repeaterless transmission through 226 km non-DSF (a total dispersion of 4100 ps/nm).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Recent advances in the care of children with acute diarrhoea: giving responsibility to the nurse and parents (1987)

Five hundred million attacks of diarrhoea occur each year in children under 5 years of age, throughout the world, and acute gastroenteritis remains a frequent cause of admission to hospital in the United Kingdom. Current practice in the treatment of diarrhoeal dehydration in the UK is focused upon intravenous rehydration. Drugs (eg antibiotics, anti-emetics, anti-diarrhoeal agents and absorbents) are commonly prescribed, and 'therapeutic' starvation, followed by cautious reintroduction of diet, is recommended. Studies conducted by health workers in developing countries have challenged these dogma. Whilst intravenous rehydration is occasionally required (eg. in shock, ileus or coma) the majority of episodes of dehydration can be treated orally. Oral rehydration is less unpleasant than intravenous infusion, safer, quicker, cheaper and readily administered by parents with nursing supervision. Recovery may be hastened by continuing to breast feed and offer normal diet, and weight loss is minimized. These principles are being applied in pilot studies at The Children's Hospital, Birmingham. Outpatient treatment is largely supervised by trained paediatric nurses, after initial medical assessment of the child. Nurses are becoming more confident in the technique of oral rehydration, coupled with early reintroduction of food. This is reflected in less discomfort and weight loss for the child, less parental anxiety, decreased length of hospital stay, and financial savings.
Video coding using global motion and brightness‐variation compensation with complexity reduction (2002)

Abstract Global motion compensation and global brightness‐variation compensation are proposed in order to deal with motion or brightness variation over the whole image. It is expected that the coding efficiency will be greatly improved by these techniques. The purpose of this investigation is to reduce the tremendous amount of computation which has especially hindered global brightness‐variation compensation. A simple method is introduced for blockwise motion estimation processing and brightness‐variation parameter estimation processing. A coding scheme is proposed, with the motion estimation procedure shared between global motion compensation and local motion compensation, so that the two functions are realized simultaneously with smaller complexity. In the case of the block size and the range of motion search in the experiment, the number of multiplications is reduced to about 1/400 as many as when the conventional compensation procedures are simply combined. As regards the coding efficiency, we demonstrate improvement integrating the effects obtained when global motion compensation and brightness‐variation compensation are separately applied. © 2002 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 86(2): 80–93, 2003; Published online in Wiley InterScience ( www.interscience.wiley. com ). DOI 10.1002/ecja.1156
Laser Communications (1988)

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsSimon Turner∗ There were several video clips shown during the presentation and where they appeared they have been described in parentheses.
ChemInform Abstract: New Quinoxaline and Pyrimido(4,5‐b)quinoxaline Derivatives. Potential Antihypertensive and Blood Platelet Antiaggregating Agents. (1990)

Abstract The title compounds (II), (IV), (V), (VII), (IX) and (X) are screened for their inhibitory activity of blood platelet aggregation and for their antihypertensive activity.
Simulation and Analysis of Extended Brake Lights for Inter-Vehicle Communication Networks (2007)

The goal of this research is to simulate and analyze an inter-vehicle communication (IVC) mobile ad hoc network (MANET). Automobiles of the future will take advantage of IVC capabilities, in which vehicles will communicate with one another wirelessly. The crash avoidance metrics partnership (CAMP) vehicle safety communications consortium (VSCC) has identified three scenarios that are representative of the capabilities of future vehicular networks: curve speed warning (CSW), traffic signal violation warning (TSVW), and extended brake lights (EBL). We consider only EBL, as it is the only scenario that involves direct communication between vehicles. This research aims to simulate the EBL scenario over an IVC network, and analyze the network using accepted metrics and benchmarks. The resulting performance data may influence and motive future research efforts.
Robust stabilization of tone reproduction curves for the xerographic process (2002)

The stabilization of a single color tone reproduction curve (TRC) is critical for high fidelity color printing. A TRC controller uses a small number of actuators and a small number of measurements to stabilize the potentially high dimensional TRC. The overall least squares deviation of the TRC from the ideal nominal TRC is minimized in the face of the many disturbances and uncertainty in the system description. The control design consists of the steps of: 1) determining a robust optimally performing static controller, and 2) realizing a causal controller. Simulations and experiments showed that the proposed controllers perform superiorly, in terms of robustness, disturbance and noise rejection, compared to integral controllers.
Willy Gerking, Die Wüstungen des Kreises Lippe (2018)

Rezension zu: Willy Gerking, Die Wüstungen des Kreises Lippe. Eine historisch-archäologische und geographische Studie zum spätmittelalterlichen Wüstungsgeschehen in Lippe. Veröffentlichungen der Altertumskommission für Westfalen, Band X. Münster: Aschendorffsche Verlagsbuchhandlung GmbH & Co. 1995. X u. 178 Seiten, 23 Abbildungen, 37 Karten. ISBN 3-402-05035-8.
Allogeneic Hematopoietic Cell Transplantation for Aggressive NK Cell Leukemia. A Center for International Blood and Marrow Transplant Research Analysis (2017)

Aggressive NK cell leukemia (ANKL) is an exceedingly rare form of leukemia and carries a poor prognosis, with a median survival of only 2 months. Using the Center for International Blood and Marrow Transplant Research database, we evaluated outcomes of allogeneic hematopoietic cell transplantation (alloHCT) in patients with ANKL. Twenty-one patients with a centrally confirmed diagnosis of ANKL were included. Median patient age was 42 years and 15 patients (71%) were Caucasian. Fourteen patients (67%) were in complete remission (CR) at the time of alloHCT, and 5 patients had active disease. Median follow-up of survivors was 25 months (range, 12 to 116). The 2-year estimates of nonrelapse mortality, relapse/progression, progression-free (PFS), and overall survival (OS) were 21%, 59%, 20%, and 24%, respectively. The 2-year PFS of patients in CR at the time of alloHCT was significantly better than that of patients with active disease at transplantation (30% versus 0%; P = .001). The 2-year OS in similar order was 38% versus 0% (P < .001). In conclusion, this registry analysis that included majority non-Asian patient population shows that alloHCT can provide durable disease control in a subset of ANKL patients. Achieving CR before transplantation appears to be a prerequisite for successful transplantation outcomes.
Synergy between Signal Transducer and Activator of Transcription 3 and Retinoic Acid Receptor-α in Regulation of the Surfactant Protein B Gene in the Lung (2004)

During respiratory cycles, airborne particles and pathogens are inhaled into the lung, which can cause cytokine production by respiratory macrophages and inflammatory responses. Secreted cytokines affect surfactant protein expression and homeostasis in the lung. In coculturing experiments in vitro, bronchoalveolar macrophages stimulated human surfactant protein B (hSP-B) gene transcription in primary alveolar type II epithelial cells in lipopolysaccharide-independent and -dependent ways. Neutralization by IL-6 antibody abolished lipopolysaccharide-dependent macrophage stimulation of hSP-B gene transcription. IL-6 treatment enhanced signal transducer and activator of transcription (Stat)3 phosphorylation at Y705 in alveolar type II epithelial cells and Clara cells in vivo. Biochemical analysis of functional domain swapping between Stat1 and Stat3 identified that the SH2 domain and the DNA binding domain are critical for Stat3 stimulation of hSP-B gene transcription. Glutathione-S-transferase pull-down study determined functional domains required for protein-protein interaction between Stat3 and retinoic acid receptor-alpha. Cotransfection of Stat3 and retinoic acid receptor-alpha into respiratory epithelial cells resulted in synergistic DNA binding and transcriptional activation on the hSP-B gene. To assess Stat3 physiological function, overexpression of a dominant negative Stat3 in respiratory epithelial cells in a doxycycline-controlled double transgenic mouse line caused pulmonary emphysema and increase of animal death during hyperoxia. Therefore, the IL-6/Stat3 signaling axis plays an important role in surfactant protein homeostasis and respiratory inflammation in the lung.
The RAD6000MC System-on-Chip Microcontroller for Spacecraft Avionics and Instrument Control (2008)

A highly integrated system-on-chip is currently in development. Based on the flight-proven RAD6000™ microprocessor, this mixed-signal microcontroller supports a wide variety of standard digital interfaces commonly used in spacecraft avionics. Multiple analog input and output channels are also provided. This paper will discuss the RAD6000mc architecture, porting of the RAD6000 processor into a reusable core, development of the analog circuitry and analog control interface core, and various applications for which the RAD6000MC is well matched.
Online and incremental algorithms for facility location (2011)

In the online and incremental variants of Facility Location, the demands arrive one-by-one and must be assigned to an open facility upon arrival, without any knowledge about future demands. In the online variant, the decisions of opening a facility at a particular location and of assigning a demand to some facility are irrevocable. In the incremental variant, the algorithm can also merge existing facilities (and the corresponding demand clusters) with each other, and only the decision of assigning some demands to the same facility is irrevocable. The goal is to maintain, either online or incrementally, a set of facilities and an assignment of the demands to them that minimize the total facility opening cost plus the assignment cost for all demands. In this survey, we discuss the previous work on online and incremental algorithms for Facility Location. In addition to the main results, namely that the competitive ratio for the online variant is Θ(log n log log n ), where n is the number of demands, and that the competitive ratio for the incremental variant is O(1), we discuss all known online and incremental Facility Location algorithms, sketch the intuition behind them and the main ideas of their competitive analysis, and discuss some applications.
Surface-Based Efficient Cloud Visualisation for Animation Applications. (2002)

For the local TV presentation of weather forecast data it is important to have high-quality and fast visualisation of clouds. In this paper we present surface-based methods for the high performance visualisation of clouds from data produced by a routine meteorological weather simulation. Isosurfaces, which are originally too coarse because of the data grid resolution are refined and deformed. The refined geometry is used for a light simulation and transparency computation.
Water resources management in an arid environment: the case of Israel (2006)

Israel is a semi-arid country, and a significant increase in population combined with sustained economic growth now place enormous pressure on the country's scarce water resources. To date however, the Israeli government has been successful in addressing this problem. Rigorous enforcement of policy, institutional and legal measures has been very effective, and in many aspects the country is a worldwide leader in water resource management. This paper therefore reviews Israel's efforts in this area in order to identify lessons that may provide useful insights for developing countries - such as China - whose future economic growth is also threatened by water scarcity. The rest of the paper is organized as follows. The second section briefly discusses current water resource availability in Israel. Section three discusses the legal framework for water resources management. Section four reviews the role of water resources institutions. Section five summarizes major technical strategies for water resource management. Section six discusses economic instruments such as water tariffs, subsidies, water trading, and private sector participation. Section seven contains concluding remarks.
Heritability of Lung Disease Severity in Cystic Fibrosis (2007)

Our heritability estimates indicate substantial genetic control of variation in CF lung disease severity, independent of CFTR genotype.
Organic electroluminescent devices and organic photo detectors for polymeric optical integrated devices (2003)

Summary form only given. The OLEDs are fabricated on a glass substrate and a polymeric substrate. The device fabricated on a polymeric substrate shows similar device characteristics to that on a glass substrate for an OLED of Alq/sub 3/ (8-hydroxyquinoline aluminum) as an emissive layer. Emission characteristics and pulse response characteristics of OLEDs are discussed. The pulse response of photo-detectors, consisting of multilayered phthalocyanines, shows that the cutoff frequency is drastically improved by decreasing the individual layer thickness and applying a reverse bias voltage.
Prophylaxis of experimental bone marrow transplant nephropathy. (1994)

Renal radiation injury is a known complication of both local kidney irradiation and total body irradiation (TBI). TBI is felt to play an important role in the late-onset chronic renal failure seen after bone marrow transplantation in human beings. Two-hundred and eleven WAG/Rij/MCW rats underwent 0 to 20 Gy TBI followed by syngeneic bone marrow transplant (BMT). Rats received either no drug or verapamil, enalapril, or captopril in the drinking water starting 9 days before TBI and continuing thereafter. Follow-up continued up to 55 weeks after TBI/BMT. No-drug irradiated animals developed significant proteinuria 6 weeks after TBI, were azotemic by 9 weeks after TBI, and were hypertensive by 13 weeks after TBI. Survival was inversely related to the dose of TBI. There was a dose-related reduction in proteinuria, blood pressure, and azotemia with increasing doses of captopril. At 500 mg/L, captopril was more effective than 50 mg/L enalapril in controlling proteinuria, blood pressure, and azotemia and in enhancing survival of irradiated animals. Verapamil, 700 mg/L, did not control proteinuria, blood pressure, or the development of renal failure and did not enhance survival when compared with no-drug irradiated animals. We conclude that angiotensin-converting enzyme inhibitors are beneficial in preventing radiation nephropathy and that control of proteinuria may be of particular importance in preventing progression of renal failure in this model.
Enhanced Inter-Prediction Via Shifting Transformation in the H.264/AVC (2012)

Inter-prediction based on block-based motion estimation (ME) is used in most video codecs. The closer the prediction to the target block, the lower the residual, and thus more efficient compression can be achieved. In this paper, a new technique called enhanced inter-prediction (EIP) is proposed to improve the prediction candidates using an additional transformation acting while performing ME. A parametric transformation acts within the coding loop of each block to modify the prediction for each motion vector candidate. The EIP is validated in the particular case of a single-parameter shifting transformation. This paper presents an efficient algorithm to compute the best shift for each prediction candidate and a model to select the optimal prediction based on minimum cost integrating the approach with existing rate-distortion optimization techniques in the H.264/AVC video codec. Results show significant improvements with an average of 6% bit-rate reduction compared to the original H.264/AVC.
Notes. Mannich Derivatives of Analgesic Agents (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes. Mannich Derivatives of Analgesic AgentsE Fry and Everette MayCite this: J. Org. Chem. 1959, 24, 1, 116–117Publication Date (Print):January 1, 1959Publication History Published online19 May 2003Published inissue 1 January 1959https://pubs.acs.org/doi/10.1021/jo01083a609https://doi.org/10.1021/jo01083a609research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interrater reliability of the unified Parkinson's disease rating scale motor examination (1994)

Interrater reliability of the Unified Parkinson's Disease Rating Scale (UPDRS) motor examination was assessed by three neurologists experienced in the administration of this scale. Intraclass correlation coefficients indicated good-to-excellent agreement for speeded repeated movements, resting tremor, arising from a chair, and gait; moderate agreement for action tremor, rigidity, posture, postural stability, and bradykinesia; and poor agreement for speech disorder and facial immobility. Overall, these results indicate that satisfactory interrater reliability is attainable with the UPDRS motor examination.
Enantioselective Synthesis of the Antiinflammatory Agent (−)-Acanthoic Acid (2001)

An enantioselective synthesis of the potent antiinflammatory agent (-)-acanthoic acid (1) is described. The successful strategy departs from (-)-Wieland-Miescher ketone (10), which is readily available in both enantiomeric forms and constitutes the starting point toward a fully functionalized AB ring system of 1. Conditions were developed for a regioselective double alkylation at the C4 center of the A ring, which produced compound 32 as a single stereoisomer. Construction of the C ring of 1 was accomplished via a Diels-Alder reaction between sulfur-containing diene 43 and methacrolein (36), which after desulfurization and further functionalization yielded synthetic acanthoic acid. The described synthesis confirms the proposed stereochemistry of the natural product and represents a fully stereocontrolled entry into an underexplored class of biologically active diterpenes.