gebhart/patrepeval huggingface dataset:
Corticosteroid Use and Complications in a US Inflammatory Bowel Disease Cohort (2016)

Prolonged corticosteroid therapy for the treatment of IBD is common and is associated with significant harm to patients. Patients with prolonged use of corticosteroids for IBD should be referred to gastroenterology early and universal efforts to improve the delivery of high quality care should be undertaken.
Tunable combline filter with continuous control of center frequency and bandwidth (2005)

A new combline filter structure with a continuous tunability for both the center frequency and bandwidth is presented in this paper. The passband-width tunability is achieved by placing variable coupling reducers between the filter resonators. The coupling reducers, operating as bandwidth control subnetworks, are designed as detuned resonators made up of a line segment ending in a variable capacitor. The proposed filter structure is experimentally validated with the design, construction in suspended stripline technology, and characterization of a low-cost filter prototype for terrestrial digital video broadcasting receivers operating in the UHF band (470-862 MHz). Other relevant factors, such as the intermodulation distortion produced by the varactors used to control the bandwidth electronically or the power-handling performance of the constructed filter, are also discussed. The reconfigurable filter module described in this paper is very suitable for the design of flexible multifunction receiver subsystems simultaneously supporting signals with a different bandwidth.
The Urbanization of Empire (2004)

Research Article| December 01 2004 The Urbanization of Empire: MEGACITIES AND THE LAWS OF CHAOS Mike Davis Mike Davis Search for other works by this author on: This Site Google Social Text (2004) 22 (4 (81)): 9–15. https://doi.org/10.1215/01642472-22-4_81-9 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Mike Davis; The Urbanization of Empire: MEGACITIES AND THE LAWS OF CHAOS. Social Text 1 December 2004; 22 (4 (81)): 9–15. doi: https://doi.org/10.1215/01642472-22-4_81-9 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsSocial Text Search Advanced Search The text of this article is only available as a PDF. Mike Davis.2004 Article PDF first page preview Close Modal Issue Section: Articles You do not currently have access to this content.
Lysine production from methanol at 50°C using Bacillus methanolicus: Modeling volume control, lysine concentration, and productivity using a three‐phase continuous simulation (1996)

A simulation was developed based on experimental data obtained in a 14-L reactor to predict the growth and L-lysine accumulation kinetics, and change in volume of a large-scale (250-m3) Bacillus methanolicus methanol-based process. Homoserine auxotrophs of B. methanolicus MGA3 are unique methylotrophs because of the ability to secrete lysine during aerobic growth and threonine starvation at 50°C. Dissolved methanol (100 mM), pH, dissolved oxygen tension (0.063 atm), and threonine levels were controlled to obtain threonine-limited conditions and high-cell density (25 g dry cell weight/L) in a 14-L reactor. As a fed-batch process, the additions of neat methanol (fed on demand), threonine, and other nutrients cause the volume of the fermentation to increase and the final lysine concentration to decrease. In addition, water produced as a result of methanol metabolism contributes to the increase in the volume of the reactor. A three-phase approach was used to predict the rate of change of culture volume based on carbon dioxide production and methanol consumption. This model was used for the evaluation of volume control strategies to optimize lysine productivity. A constant volume reactor process with variable feeding and continuous removal of broth and cells (VFcstr) resulted in higher lysine productivity than a fed-batch process without volume control. This model predicts the variation in productivity of lysine with changes in growth and in specific lysine productivity. Simple modifications of the model allows one to investigate other high-lysine-secreting strains with different growth and lysine productivity characteristics. Strain NOA2#13A5-2 which secretes lysine and other end-products were modeled using both growth and non-growth-associated lysine productivity. A modified version of this model was used to simulate the change in culture volume of another L-lysine producing mutant (NOA2#13A52-8A66) with reduced secretion of end-products. The modified simulation indicated that growth-associated production dominates in strain NOA2#13A52-8A66. © 1996 John Wiley & Sons, Inc.
Effect of xylose on the molecular and particle size distribution of peanut hydrolysate in Maillard reaction system (2011)

The study shows that both peptide degradation and peptide cross-linking occurred during the Maillard reaction. The thermal degradation product (TDP) and MRPs had significantly different molecular size distribution, and the particle size distribution of TDPs and MRPs had similar change tendency to that of the molecular size distribution. These would provide an insight into the formation mechanism of MRPs.
Recovery of Carbonate Sand Beaches on San Salvador Island, Bahamas From Damage by Hurricane Frances (2004) (2012)

East Beach and Hanna Bay Beach, located on the northeast coast of San Salvador, were two of the island's beaches most heavily impacted by Hurricane Frances (category 3) on September 2, 2004. A maximum storm surge of 3.1 m was reported for East Beach, with erosion occurring up to 70 m inland from the wave-break line and resulting in scarps cut into dunes of up to 1.5 m height. In January 2005, 5 beach profile stations along 1 km of East Beach and 3 stations along Hanna Bay Beach were established to monitor long-term coastal recovery from hurricane damage. East Beach was profiled 6 times and Hanna Bay Beach profiled 5 times using the stake and horizon-sighting method, beginning in January 2005 through January 2010. Dune vegetation also was greatly damaged by Hurricane Frances, and its recovery and stabilizing effects on dunes was noted.
Rapid and shape-controlled synthesis of “clean” star-like and concave Pd nanocrystallites and their high performance toward methanol oxidation (2012)

Uniform “clean” star-shaped and concave palladium (Pd) nanocrystallites (NCs) are first successfully synthesized via a very simple and rapid route without using any surfactants. Interestingly, the as-prepared Pd NCs manifest superior electrocatalytic activity and stability toward methanol oxidation over the commercial Pd/C catalyst.
An All-MOS companded PCM voice encoder (1976)

A per channel μ 255 CPCM encoder which can be fabricated as a single MOS chip, will be described. Experimental results from a prototype in which all analog portions were fabricated as MOS integrated circuits will be discussed.
Fluidic Self-Assembly of Millimeter-Scale Thin Parts at Air-Water Interface (2012)

Thesis (Ph.D.)--University of Washington, 2012
Complete spontaneous resolution of compressive chronic subdural hematoma in a patient with liver failure. (2012)

Chronic subdural hematoma is usually caused by minor head trauma and occurs frequently with older people. Predisposing factors include alcohol abuse, epilepsy and coagulopathy. This report presents a 65-year old woman who had a large, mixed density, left sided compressive chronic subdural hematoma diagnosed by computed tomography. She also displayed a moderate neurological deficit on admission, confusion and behavioral disorder with Glasgow Coma Score 10. The computed tomography and neurological parameters indicated the necessity of surgery. A difficult general condition and coagulation factor disorder in this patient were determinative for the decision for non-operative treatment. It is very rare that a large chronic subdural hematoma is resolved completely spontaneously, but in our case conservative treatment gave an excellent result.
Genomic diversity landscape of the honey bee gut microbiota (2019)

The structure and distribution of genomic diversity in natural microbial communities is largely unexplored. Here, we used shotgun metagenomics to assess the diversity of the honey bee gut microbiota, a community consisting of few bacterial phylotypes. Our results show that most phylotypes are composed of sequence-discrete populations, which co-exist in individual bees and show age-specific abundance profiles. In contrast, strains present within these sequence-discrete populations were found to segregate into individual bees. Consequently, despite a conserved phylotype composition, each honey bee harbors a distinct community at the functional level. While ecological differentiation seems to facilitate coexistence at higher taxonomic levels, our findings suggest that, at the level of strains, priority effects during community assembly result in individualized profiles, despite the social lifestyle of the host. Our study underscores the need to move beyond phylotype-level characterizations to understand the function of this community, and illustrates its potential for strain-level analysis.
Automated threshold detection using a pyramid data structure (2003)

An approach to detect the thresholds automatically in a noisy histogram is discussed. The histogram is considered as a 1D image. Then, a histogram pyramid is built for smoothing the noisy histogram and eliminating the small noise peaks and valleys. The threshold is first found at the higher level of the histogram pyramid and then mapped back to the successive levels. The results show that the thresholds obtained are close to the optimal solution in terms of the statistical point of view and are of reasonable values in some complicated and noisy histograms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Costal diaphragm curvature in the dog (1993)

The curvature of the midcostal region of the diaphragm in seven dogs was determined at functional residual capacity (FRC) and end inspiration during spontaneous breathing and mechanical ventilation and at total lung capacity in the prone and supine positions. Metallic markers were attached to muscle fibers on the abdominal surface of the diaphragm, and the dog was allowed to recover from surgery. The three-dimensional positions of the markers were determined by biplane videofluoroscopy. A quadratic surface was fit to the bead positions. The principal axes of the quadratic surface lie nearly along and perpendicular to the muscle fibers. In both the supine and prone positions, the values of the principal curvatures were similar at FRC and end inspiration during spontaneous breathing, when muscle tension and transdiaphragmatic pressure both increase with increasing lung volume, and during mechanical ventilation and passive inflation to total lung capacity, when both decrease relative to their magnitude at FRC. No abrupt change of curvature, which might be expected at the edge of the zone of apposition, was apparent. The curvature along the muscle fiber was 0.35 +/- 0.07 cm-1; the curvature perpendicular to the muscle fiber was much smaller, 0.06 +/- 0.01 cm-1. The costal region of the diaphragm displaces and shortens as lung volume increases, but its shape, as described by its curvatures, does not change substantially.
A 10Gb/s wire-line transceiver with half rate period calibration CDR (2009)

This paper presents the design of a 10 Gb/s low power wire-line transceiver in 65 nm CMOS process with 1 V supply voltage. The transmitter occupies an area of 430 mum times 240 mum, consumes 50.56 mW power and has a 5-order programmable pre-emphasis equalizer. The receiver occupies an area of 300 mum times 500 mum. With the novel half rate period calibration clock data recovery (CDR) circuit, the receiver consumes only 52 mW power. The receiver combines a low power wideband programmable continuous time linear equalizer (CTLE) and a 3-order decision feedback equalizer (DFE).
Integrated Semantics Service Platform for the Internet of Things: A Case Study of a Smart Office (2015)

The Internet of Things (IoT) allows machines and devices in the world to connect with each other and generate a huge amount of data, which has a great potential to provide useful knowledge across service domains. Combining the context of IoT with semantic technologies, we can build integrated semantic systems to support semantic interoperability. In this paper, we propose an integrated semantic service platform (ISSP) to support ontological models in various IoT-based service domains of a smart city. In particular, we address three main problems for providing integrated semantic services together with IoT systems: semantic discovery, dynamic semantic representation, and semantic data repository for IoT resources. To show the feasibility of the ISSP, we develop a prototype service for a smart office using the ISSP, which can provide a preset, personalized office environment by interpreting user text input via a smartphone. We also discuss a scenario to show how the ISSP-based method would help build a smart city, where services in each service domain can discover and exploit IoT resources that are wanted across domains. We expect that our method could eventually contribute to providing people in a smart city with more integrated, comprehensive services based on semantic interoperability.
Energy values in pig nutrition:I. The relationship between digestible energy, metabolizable energy and total digestible nutrient values of a range of feedstuffs (1975)

SUMMARY Nineteen feedstuffs were evaluated for total digestible nutrients (TDN), digestible energy (DE) and metabolizable energy (ME) using growing pigs. DE values, on a drymatter basis, ranged from 1570 kcal/kg D.M. (grassmeal) to 4890 kcal/kg D.M. (BP Grangemouth protein). ME averaged 97·4% of DE for cereal feeds and 81·9% of DE for protein feeds, the ratio of DE to ME being significantly affected by the crudeprotein content of the feedstuff: ME/DE × 100 = 99·7–0·18 × crude protein (%): r = –0·94; P < 0·01. TDN was more closely related to ME than DE: DE (kcal/kg D.M.) = 45 TDN + 156: r = 0·92; P < 0·01, ME (kcal/kg D.M.) = 43 TDN + 71: r = 0·98; P < 0·01. ME values were corrected to both 30% and 0% nitrogen retention. Correction to 30% retention caused a maximum change of 3% in ME value while correction to 0% retention had a variable effect related to protein content of the feedstuff: (ME( N 0 )/ME) × 100 = 98·3–0·113 × crude protein (%): r = –0·80; P < 0·01.
Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy (2019)

The PINK1 protein kinase activates the PARK2 ubiquitin ligase to promote mitochondrial ubiquitylation and recruitment of ubiquitin-binding mitophagy receptors typified by OPTN and TAX1BP1. Here, we combine proximity biotinylation of OPTN and TAX1BP1 with CRISPR-Cas9-based screens for mitophagic flux to develop a spatial proteogenetic map of PARK2-dependent mitophagy. Proximity labeling of OPTN allowed visualization of a "mitochondrial-autophagosome synapse" upon mitochondrial depolarization. Proximity proteomics of OPTN and TAX1BP1 revealed numerous proteins at the synapse, including both PARK2 substrates and autophagy components. Parallel mitophagic flux screens identified proteins with roles in autophagy, vesicle formation and fusion, as well as PARK2 targets, many of which were also identified via proximity proteomics. One protein identified in both approaches, HK2, promotes assembly of a high-molecular weight complex of PINK1 and phosphorylation of ubiquitin in response to mitochondrial damage. This work provides a resource for understanding the spatial and molecular landscape of PARK2-dependent mitophagy.
Sudden cardiac death: epidemiology and temporal trends. (2005)

Sudden cardiac death (SCD) now accounts for more than half of all coronary heart disease deaths in the United States. The majority of cases are due to underlying coronary artery disease, and deaths from both coronary artery disease and SCD have declined markedly over the past several decades due to improved primary and secondary prevention and treatment strategies. This review examines the current statistics on the prevalence of SCD, and identifies those patients at greatest risk. It also discusses existing tests and treatments, including medication that results in neurohormonal antagonism, and devices such as the implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy with a defibrillator (CRT-D). Along with increased public awareness of SCD as a major health risk, physicians are advised to implement proven effective drug and devices that can improve survival.
Association and linkage analysis of the  -adducin gene and blood pressure (2000)

In Milan hypertensive rats, a variant in the alpha-adducin gene has been shown to account for approximately 50% of the interindividual variation in blood pressure levels between these animals and their normotensive counterparts. Additional studies have suggested that a polymorphism within exon 10 of the human alpha-adducin gene (Gly-460-Trp) may be associated with hypertension and salt sensitivity. On the basis of these observations, we investigated variation within or near the human alpha-adducin gene for linkage and association with a locus influencing blood pressure levels in 281 nuclear families (774 siblings aged 5 to 37 years; 380 parents aged 26 to 57 years), selected from the white population of Rochester, Minnesota, without regard to health. Sib pair linkage analyses (n = 852 sibling pairs) using a dinucleotide repeat marker (D4S43) that maps approximately 660 kb from the alpha-adducin gene provided no evidence of linkage between this marker locus and a locus influencing systolic, diastolic, or mean blood pressure levels. Allele frequencies for the Gly-460-Trp polymorphism were similar to those reported in other white populations (Gly = 0.812, Trp = 0.188); however, this polymorphism was not associated with any measure of blood pressure level in either parents or siblings. Therefore, variation within the alpha-adducin gene does not appear to have a major influence on measures of blood pressure in white families from Rochester, Minnesota.
Hierarchical wavelet networks for facial feature localization (2003)

We present a technique for facial feature localization using a two-level hierarchical wavelet network. The first level wavelet network is used for face matching, and yields an affine transformation used for a rough approximation of feature locations. Second level wavelet networks for each feature are then used to fine-tune the feature locations. Construction of a training database containing hierarchical wavelet networks of many faces allows features to be detected in most faces. Experiments show that facial feature localization benefits significantly from the hierarchical approach. Results compare favorably with existing techniques for feature localization.
The flgE gene of Campylobacter coli is under the control of the alternative sigma factor sigma54 (1997)

The flgE gene encoding the flagellar hook protein of Campylobacter coli VC167-T1 was cloned by immunoscreening of a genomic library constructed in lambdaZAP Express. The flgE DNA sequence was 2,553 bp in length and encoded a protein with a deduced molecular mass of 90,639 Da. The sequence had significant homology to the 5' and 3' sequences of the flgE genes of Helicobacter pylori, Treponema phagedenis, and Salmonella typhimurium. Primer extension analysis indicated that the VC167 flgE gene is controlled by a sigma54 promoter. PCR analysis showed that the flgE gene size and the 5' and 3' DNA sequences were conserved among C. coli and C. jejuni strains. Southern hybridization analyses confirmed that there is considerable sequence identity among the hook genes of C. coli and C. jejuni but that there are also regions within the genes which differ. Mutants of C. coli defective in hook production were generated by allele replacement. These mutants were nonmotile and lacked flagellar filaments. Analyses of flgE mutants indicated that the carboxy terminus of FlgE is necessary for assembly of the hook structure but not for secretion of FlgE and that, unlike salmonellae, the lack of flgE expression does not result in repression of flagellin expression.
Evaluation of Discharge Coefficients for Window Openings in Wind Driven Natural Ventilation (2006)

This paper describes the classical approach for calculation of wind driven airflow through large openings in buildings and discusses the fulfilment of the limiting assumptions. It is demonstrated that the limiting assumptions are not fulfilled for large openings in buildings for cross ventilation, and therefore, the classical approach is not appropriate for prediction of airflow through large openings in buildings in the cross ventilation case. Using the approach for real openings and estimating the discharge coefficient for window openings has also not been very successful. The discharge coefficient cannot be regarded as a constant and it is very difficult to estimate correct values resulting in less accuracy of prediction of natural ventilation.
Effect of once weekly dulaglutide by baseline beta‐cell function in people with type 2 diabetes in the AWARD programme (2018)

Glucagon-like peptide-1 receptor agonists lower blood glucose in type 2 diabetes (T2D) partially through glucose-dependent stimulation of insulin secretion. The aim of this study was to investigate whether beta-cell function (as measured by HOMA2-%B) at baseline affects the glycaemic response to dulaglutide. Dulaglutide-treated patients from AWARD-1, AWARD-3 and AWARD-6 clinical studies were categorised based on their homeostatic model assessment of beta-cell function (HOMA2-%B) tertiles. Changes in glycaemic measures in response to treatment with once-weekly dulaglutide were evaluated in each HOMA2-%B tertile. Patients with low HOMA2-%B had higher baseline glycated haemoglobin (HbA1c), fasting and postprandial blood glucose, and longer duration of diabetes (P < .001, all) (mean low, middle and high tertiles with dulaglutide 1.5 mg: HOMAB-2%B, 31%, 58%, 109%; HbA1c, 8.7%, 7.7%, 7.3%, respectively). At 26 weeks, the low tertile experienced larger reductions in HbA1c compared to the high tertile with dulaglutide 1.5 mg (mean; -1.55% vs. -0.98% [-16.94 vs. -10.71 mmol/mol]). Differences between low and high tertiles disappeared when adjusted for baseline HbA1c (LSM; -1.00 vs. -1.18% [-10.93 vs. -12.90 mmol/mol]). Greater decreases in fasting blood glucose and greater increases in fasting C-peptide were observed in the low tertile. Similar increases in HOMA2-%B were observed in all tertiles. Dulaglutide demonstrated clinically relevant HbA1c reduction irrespective of estimated baseline beta-cell function.