gebhart/patrepeval huggingface dataset:
Circular marzo 17 de 2020 - Superintendencia de Industria y Comercio (2020)

Suspension Procedimiento de identificacion biometrica mediante huella dactilar cuando se solicite la inscripcion de actos y documentos o modificacion de la informacion de los registros publicos.
Rapid changes in the concentration of phosphoenolpyruvate carboxykinase mRNA in rat liver and kidney. Effects of insulin and cyclic AMP. (1982)

Starvation and diabetes both caused a marked increase in the concentration of hepatic phosphoenolpyruvate caroboxykinase mRNA while the administration of insulin to diabetic rats or refeeding glucose to starved animals caused a marked reduction in the levels of enzyme mRNA as measured by hybridization using a cDNA probe.l The Administration of dibutyryl cAMP to a starved-refed cat caused an 8-fold induction of phosphoenolpyruvate carboxykinase mRNA in 1 h. Triamcinolone plus acidosis induced the levels of enzyme mRNA in kidney 3-fold within 6 h, however, starvation for 24h had only marginal effects. In all of the above conditions, the levels of phosphoenolpyruvate carboxykinase mRNA measured by hybridization assay agreed well with the relative levels of translatable mRNA for the enzyme. The half-time of phosphoenolpyruvate carboxykinase mRNA, determined after the administration of either alpha-amanitin or cordycepin to starved animals, was approximately 40 min. However, cycloheximide either alone or together with cordycepin, not only prevented the decrease in phosphoenolpyruvate carboxykinase mRNA sequence abundance, but induced it 2-fold. Cycloheximide itself, when injected into 21-day fetal rats in utero caused an induction of enzyme mRNA equal to that noted when dibutyryl cAMP was administered. The mRNA for phosphoenolpyruvate carboxykinase is approximately 2.8 kb in length, but nuclei from the livers of diabetic rats contain a number of putative precursor RNA species for the enzyme, up to 6.5 kb in size, all containing a poly(A) tail. Two hours after refeedng glucose to a starved rat, these nuclear RNA species could no longer be detected by hybridization to our cDNA probe.
Metacognition, cognition and learning: Old dubitations and new directions (1994)

Research into metacognition, a relatively new construct in the cognitive sciences, has been prodigious over the last decade. This is despite continuing doubts about its heuristic value. Initial doubts emphasised difficulties associated with definition of the construct, the limited predictive power of metacognitive task performance in relation to actual cognitive task or test performance and, relatedly, difficulties in operationalising the construct in specific thinking and problem solving contexts. Subsequent cross-cultural research has focussed on the degree to which metacognitive thinking is situationalised according to cultural context and thinking task, despite the implication that such thinking, by nature, is “multicontextual.” It then questioned the extent to which different social and cultural groups differ in their construction of the metacognitive level of knowledge and its relevance to their everyday life task performance and thinking.
Pre-decoding mechanism for superscalar architecture (2002)

A predecoding mechanism for superscalar processors that is necessary to issue instructions to plural functional units is described. Using a predecoding mechanism, a processor can issue instructions without increasing the cycle time or the branch penalty. The predecoder decides which functional unit should execute an instruction during a cache miss and refill. A special tag, the call predecode tag, is generated by the predecoder. This tag is saved with instructions to an instruction cache memory. The processor fetches instructions with the predecode tag and issues instructions controlled by the predecode tag. Using this mechanism, fast cycle times, comparable to those of RISC processors, are attained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cross-Presentation by Dendritic Cells of Tumor Antigen Expressed in Apoptotic Recombinant Canarypox Virus-Infected Dendritic Cells (2001)

We have investigated the possible usefulness of recombinant canarypox virus (ALVAC) encoding the melanoma-associated Ag, Melan-A/MART-1 (MART-1), in cancer immunotherapy, using a dendritic cell (DC)-based approach. ALVAC MART-1-infected DC express, and are able to process and present, the Ag coded by the viral vector. One consistent feature of infection by ALVAC is that these viruses induce apoptosis, and we show cross-presentation of Ag when uninfected DC are cocultured with ALVAC MART-1-infected DC. Uptake of apoptotic virally infected DC by uninfected DC and subsequent expression of tumor Ag in the latter were verified by flow cytometry analysis, image cytometry, and confocal microscopy. Functional activity was monitored in vitro by the stimulation of a MART-1-specific cytotoxic T cell clone. Heightened efficiency in Ag presentation is evidenced in the 2- to 3-fold increase in IFN-gamma production by the T cell clone, as compared with the ALVAC-infected DC alone. Cocultures of ALVAC MART-1-infected and uninfected DC are able to induce MART-1-specific T cell immune responses, as assessed by HLA class I/peptide tetramer binding, IFN-gamma ELISPOT assays, and cytotoxicity tests. Overall, our data indicate that DC infected with recombinant canarypox viruses may represent an efficient presentation platform for tumor Ags, which can be exploited in clinical studies.
LTCC Wide-Band Ridge-Waveguide (1999)

A ridge-waveguide tap-in coupling structure is ap- plied to the design of wide-band ridge-waveguide bandpass filters using low-temperature cofired ceramic (LTCC). The design is based on rigorous mode-matching modeling, which takes the higher order mode interactions into account. Design procedure is described and design examples are given to demonstrate the features of the proposed coupling structure. A wide-band LTCC ridge-waveguide filter is simulated and successfully built. Good experimental results are obtained.
The Arabidopsis thaliana MYB60 promoter provides a tool for the spatio-temporal control of gene expression in stomatal guard cells (2013)

Plants have evolved different strategies to resist drought, of which the best understood is the abscisic acid (ABA)-induced closure of stomatal pores to reduce water loss by transpiration. The availability of useful promoters that allow for precise spatial and temporal control of gene expression in stomata is essential both for investigating stomatal regulation in model systems and for biotechnological applications in field crops. Previous work indicated that the regulatory region of the transcription factor AtMYB60 specifically drives gene expression in guard cells of Arabidopsis, although its activity is rapidly down-regulated by ABA. Here, the activity of the full-length and minimal AtMYB60 promoters is reported in rice (Oryza sativa), tobacco (Nicotiana tabacum), and tomato (Solanum lycopersicum), using a reporter gene approach. In rice, the activity of both promoters was completely abolished, whereas it was spatially restricted to guard cells in tobacco and tomato. To overcome the negative effect of ABA on the AtMYB60 promoter, a chimeric inducible system was developed, which combined the cellular specificity of the AtMYB60 minimal promoter with the positive responsiveness to dehydration and ABA of the rd29A promoter. Remarkably, the synthetic module specifically up-regulated gene expression in guard cells of Arabidopsis, tobacco, and tomato in response to dehydration or ABA. The comparative analysis of different native and synthetic regulatory modules derived from the AtMYB60 promoter offers new insights into the functional conservation of the cis-mechanisms that mediate gene expression in guard cells in distantly related dicotyledonous species and provides novel tools for modulating stomatal activity in plants.
STATE-LOCAL GOVERNMENT RELATIONS IN NIGERIA’S FOURTH REPUBLIC: AN ASSESSMENT OF THE (1999 – 2010) EXPERIENCE (2012)

The mutual working relationship between and amongst the federal, state and local councils in Nigeria, just like those of advanced democracies is germane to this study. The paper is an empirical theoretical expositions of the chequered relationship that has existed between the three tiers of government in Nigeria since political independence in 1960 to date. The position of this paper is that the place of local councils as enshrined in the 1999 constitution (as amended) is practically honored in the breach than in strict observance. Hence, local councils in Nigeria have been highly politicize by the powers that be, and the true position of the constitution on the status of the councils are greatly in doubt. Of particular importance in this paper is the dynamics of federal, state and local council relations in the erstwhile Obasanjo administration and the kind of contradictions the administration posed in the corporate affairs of state. The paper concludes that greater autonomy, consensus building, adequate constitutional obligations should be granted to local councils to enhance overall best practices as well as grassroot transformation and sustainable development.
Theoretical Insights on A series of Cyclic Energetic Derivatives (2018)

Abstract Cyclic energetic derivatives based on guanidine and 1,1‐diaminoethene were designed and investigated systematically using density functional theory methods. The optimized geometry, heats of formation, heats of detonation, detonation velocities, detonation pressures as well as bond dissociation energies were calculated at the B3LYP/6‐31G(d,p) level. It is found that the parent molecules possess high positive heats of formation (from 196.3 to 367.1 kJ mol −1 ) which in turn will lead to the high positive heats formation of the designed compounds (from 340.2 to 1312.8 kJ mol −1 ). Besides, all the designed compounds have acceptable detonation properties (heats of detonation, from 434.3 to 2006.6 cal g −1 ; densities, from 1.49 to 2.38 g cm −3 ; detonation velocities, from 6.14 to 11.7 km s −1 ; detonation pressures, from 14.9 to 67.7 GPa) and moderated thermal stabilities (bond dissociation energies were from 11.3 to 118.9 kJ mol −1 ). Take both of detonation properties and thermal stabilities into consideration, compounds A4, B4, C1, C2, C4 and D4 were regarded as the promising candidates for high energy density materials. Finally, frontier molecular orbitals, electronic densities and electrostatic potentials of compounds A4, B4, C1, C2, C4 and D4 were also simulated. All the presented data may provide comprehensive information on laboratory synthesis, physical and chemical properties of these promising explosives.
Effects of sex steroids on proliferation in normal mammary tissue (1998)

Numerous women are treated with a combination of oestrogen and progestogen for contraception and hormone replacement therapy worldwide. A possible increased risk of cancer in target organs has been discussed vividly for many years. While oestrogens are clearly mitogenic for breast epithelial cells, there has been considerable uncertainty about the effects of progestogens. This article reviews current knowledge on this field, including our own data. Oestrogen receptors are down-regulated during the luteal phase, while progesterone receptors remain at a high level throughout the menstrual cycle. According to most studies, in vivo proliferation of normal breast epithelial cells is higher during the luteal phase in the vast majority of women. Normal breast tissue can convert oestrone sulphate to oestradiol. A negative correlation between the levels of circulating oestradiol and the enzyme converting oestrone into oestradiol suggests a local regulatory mechanism of tissue oestradiol formation. Serum progesterone levels correlate positively with sulphatase activity while 19-norsteroid progestogens may be inhibitory. We found that long-term continuous combined hormonal treatment with conjugated equine oestrogens and medroxyprogesterone acetate induced a proliferative response in the breasts of surgically postmenopausal macaques. The effect of combined treatment was more pronounced than that of oestrogen treatment alone. Both endogenous progesterone and exogenous progestogens increase proliferation of breast epithelial cells. Exogenous progestogens down-regulate both oestrogen and progesterone receptors. Oestrogen and progestogens may have both direct and indirect stimulating effects on proliferation. The finding of a positive correlation between insulin-like growth factor I messenger RNA and proliferation found in hormonally treated women with low receptor levels suggests the possibility of nonreceptor-mediated effects of sex steroids on proliferation, which needs to be investigated further.
Biochemical Behavior of Synthetic Detergents (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiochemical Behavior of Synthetic DetergentsClair N. Sawyer, Richard H. Bogan, and James R. SimpsonCite this: Ind. Eng. Chem. 1956, 48, 2, 236–240Publication Date (Print):February 1, 1956Publication History Published online1 May 2002Published inissue 1 February 1956https://pubs.acs.org/doi/10.1021/ie50554a026https://doi.org/10.1021/ie50554a026research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A least squares multiple constraint direct data domain approach for STAP (2004)

Traditionally, statistical space-time adaptive processing (STAP) approaches have been implemented to detect targets using an airborne radar system. These approaches typically assume a wide sense stationary environment and utilize auxiliary training data to estimate the statistics of the interference. Unfortunately the airborne radar environment can be highly non-stationary and may contain coherent interferers, which could drastically impact statistical STAP performance. Various approaches have been investigated to address this problem. One approach is the direct data domain least squares (D3LS) approach. This deterministic least squares adaptive signal processing technique operates on a "snapshot-by-snapshot" basis to determine the adaptive weights for nulling interferers and estimating signals of interest (SOI). Due to the reduced training data set (one range ring only - the range ring under test) and because of the particular least squares techniques employed, this approach can readily be implemented in real time in field deployable sensor signal processing systems. This paper presents an improvement to the existing D3LS approaches for radar processing. By implementing multiple space-time constraints system gain is maintained on the signal of interest when the signal arrives slightly off-set in angle, Doppler, or both. To illustrate this concepts an airborne radar simulation is used to generate radar data, and the D3LS processing results are presented.
Detection of solder joint degradation using RF impedance analysis (2008)

The trend for many types of electronic products is toward higher operating frequencies or digital bit rates. At high frequencies, signal propagation is concentrated at the surface of interconnects, a phenomenon known as the skin effect. Degradation of interconnects, such as cracking of solder joints due to fatigue or shock loading, also usually initiates at the surface and propagates inward. Therefore, even a small crack at the surface of a solder joint may affect the performance of high speed electronic assemblies. Traditional DC resistance measurements are not appropriate for detecting such a small fault. More accurate and sensitive alternatives are required for monitoring the reliability of current and future electronic products. RF impedance analysis offers an improved means of sensing interconnect degradation. This study demonstrates the use of RF impedance changes as an early indicator of physical degradation of solder joints, due to the skin effect, and compares this to DC resistance measurements. Mechanical shear tests at an elevated temperature have been conducted with an impedance- controlled circuit board on which a surface mount component was soldered. Simultaneous measurements were performed of DC resistance and the time domain reflection coefficient, as a measure of RF impedance, while the solder joints were stressed. The RF impedance was observed to increase in response to cracking of the solder joint earlier than the DC resistance. These results were qualitatively repeatable over multiple trials.
Inhibitory Compounds of .ALPHA.-Glucosidase Activity from Arctium lappa L. (2005)

Methanol extract from Arctium lappa L. showed an inhibitory activity of α-glucosidase. The methanol extract was re-extracted with ethyl acetate and water. The ethyl acetate extract showed inhibitory activity. The inhibitory compound was isolated from the ethyl acetate extract and identified as sitosterol-β -D-glucopyranoside (1) by EI-MS, FAB-MS, IR, 1H and 13C NMR spectroscopy. Compound 1 inhibited 97.3% of α-glucosidase activity at a concentration of 200.0 μ mol/mL, and the ID50 (50% inhibition dose) value was 30 μ mol/mL. In addition, the inhibitory compounds from the ethyl acetate extract were also identified as methyl palmitate (2), methyl linoleate (3) and methyl linoleneate (4) by GC-MS analysis. Compound 2-4 inhibited 73.4%, 66.5% and 68.5% of α-glucosidase activity at a concentration of 200 μ mol/mL, and the ID50 values were 52.8, 47.5 and 46.7 μ mol/mL. To research the structure-activity relationship, methyl steareate (5), methyl oleate (6), palmitic acid (7), linoleic acid (8), linolenic acid (9), stearic acid (10) and oleic acid (11) were also assayed.
Multiple agents moving target search (2003)

We investigated the association between the clinical and histopathological classifications of actinic keratosis (AK) and the efficacy of topical imiquimod treatment. Forty patients (55 lesions) with AK were treated with topical 5% imiquimod and the efficacy of imiquimod for AK was evaluated based on the clinical/histopathological changes. The complete remission (CR) rates in patients with the different clinical classifications of AK were 85.4% (erythematous type) and 46.2% (hyperkeratotic type). The CR rates in the different histopathological classifications of AK were 80% (hypertrophic type), 81.8% (atrophic type) and 42.9% (bowenoid type). The results revealed that determining the clinical and histopathological type of AK was important for selecting a therapeutic method. The topical imiquimod treatment could be expected to be more effective for AK clinically classified as the erythematous type, or histopathologically classified as the atrophic or hypertrophic type. However, it would be expected to be less effective for the treatment of AK clinically classified as the hyperkeratotic type or histopathologically classified as the bowenoid type. Our observations suggest that we can predict the efficacy of topical imiquimod therapy in AK by determining its clinical and histopathological type.
Synthesis of New Phenanthroline‐Based Heteroditopic Ligands – Highly Efficient and Selective Fluorescence Sensors for Copper(II) Ions (2006)

Abstract The heteroditopic phenanthroline derivatives 5,6‐bis(2‐pyridylcarboxamido)‐1,10‐phenanthroline (H 2 L 1 ) and 5,6‐bis[(4‐methoxy‐2‐pyridyl)carboxamido]‐1,10‐phenanthroline (H 2 L 2 ) have been prepared and characterized, together with their luminescent ruthenium(II) complexes [Ru(bpy) 2 (H 2 L 1,2 )](PF 6 ) 2 and [Ru(H 2 L 1 ) 3 ](PF 6 ) 2 and the corresponding iron(II) complex [Fe(H 2 L 1 ) 3 ](PF 6 ) 2 . In these complexes, the metal ion is coordinated by the bidentate phen site of H 2 L. The luminescence of the ruthenium complexes ( λ ex = 450 nm, λ em ca. 620 nm) is completely quenched by Cu 2+ ions in the micromolar concentration range and, to a lesser extent, by other metal ions. At pH 5, the response of the luminescent sensors is highly Cu 2+ ‐selective. Heterodinuclear complexes [Ru(bpy) 2 (LM)](PF 6 ) 2 , [Ru(LM) 3 ](PF 6 ) 2 , and [Fe(LM) 3 ](PF 6 ) 2 have been isolated for M = Cu 2+ , Ni 2+ , Co 2+ , and Pd 2+ . It is suggested that M is coordinated to the tetradentate N4 site of L by two deprotonated amide N atoms and two pyridyl groups. This coordination type is confirmed by the EPR spectrum of the compound [Ru II (bpy) 2 (L 1 Cu II )](PF 6 ) 2 .(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Stereoselective additions to [60]fullerene (1996)

1,3-Dipolar cycloaddition of chiral azomethine ylides to C60 affords mixtures of diastereoisomeric fulleropyrrolidines, which can be seperated by flash chromatography; the structure of the adducts is supported by unambiguous NOE enahancements, and CD curves of the adducts can be of help in the assignment of the absolute configuration.
Challenges of drug resistance in the management of pancreatic cancer (2010)

The current treatment of choice for metastatic pancreatic cancer involves single-agent gemcitabine or a combination of gemcitabine with capecitabine or erlotinib (a tyrosine kinase inhibitor). Only 25–30% of patients respond to this treatment and patients who do respond initially ultimately exhibit disease progression. Median survival for pancreatic cancer patients has reached a plateau due to inherent and acquired resistance to these agents. Key molecular factors implicated in this resistance include: deficiencies in drug uptake, alteration of drug targets, activation of DNA repair pathways, resistance to apoptosis and the contribution of the tumor microenvironment. Moreover, for newer agents including tyrosine kinase inhibitors, overexpression of signaling proteins, mutations in kinase domains, activation of alternative pathways, mutations of genes downstream of the target and/or amplification of the target represent key challenges for treatment efficacy. Here we will review the contribution of known mechanisms and markers of resistance to key pancreatic cancer drug treatments.
A new multichip module using a copper polyimide multilayer substrate (1989)

A new multichip module using a multilayer substrate with a polyimide dielectric and a fine pattern of copper conductors is presented. This substrate contains small copper columnar vias which reduce the thermal resistance of polyimide layers without causing a channel accommodation decrease, and thin-film resistors for terminated transmission. This module can densely mount high-speed LSI chips that produce twice as much heat as those in conventional modules. Furthermore, this module can transmit high-speed pulses at over 2 Gb/s.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>