gebhart/patrepeval huggingface dataset:
Integrated assembly and motion planning using regrasp graphs (2016)

This paper presents an integrated assembly and motion planning system to recursively find the assembly sequence and motions to assemble two objects with the help of a horizontal surface as the supporting fixture. The system is implemented in both assembly level and motion level. In the assembly level, the system checks all combinations of the assembly sequences and gets a set of candidates. Then, for each candidate assembly sequence, the system incrementally builds regrasp graphs and performs recursive search to find a pick-and-place motion in the motion level to manipulate the base object as well as to assemble the other object to the base. The system integrates the candidate assembly sequences computed in the assembly level incrementally and recursively with graph searching and motion planning in the motion level and plans the assembly sequences and motions integratedly for assembly tasks. Both simulation and real-world experiments are performed to demonstrate the efficacy of the integrated planning system.
Integrated optical sensing of dissolved oxygen in microtiter plates: A novel tool for microbial cultivation (2003)

Microtiter plates with integrated optical sensing of dissolved oxygen were developed by immobilization of two fluorophores at the bottom of 96-well polystyrene microtiter plates. The oxygen-sensitive fluorophore responded to dissolved oxygen concentration, whereas the oxygen-insensitive one served as an internal reference. The sensor measured dissolved oxygen accurately in optically well-defined media. Oxygen transfer coefficients, k(L)a, were determined by a dynamic method in a commercial microtiter plate reader with an integrated shaker. For this purpose, the dissolved oxygen was initially depleted by the addition of sodium dithionite and, by oxygen transfer from air, it increased again after complete oxidation of dithionite. k(L)a values in one commercial reader were about 10 to 40 h(-1). k(L)a values were inversely proportional to the filling volume and increased with increasing shaking intensity. Dissolved oxygen was monitored during cultivation of Corynebacterium glutamicum in another reader that allowed much higher shaking intensity. Growth rates determined from optical density measurement were identical to those observed in shaking flasks and in a stirred fermentor. Oxygen uptake rates measured in the stirred fermentor and dissolved oxygen concentrations measured during cultivation in the microtiter plate were used to estimate k(L)a values in a 96-well microtiter plate. The resulting values were about 130 h(-1), which is in the lower range of typical stirred fermentors. The resulting maximum oxygen transfer rate was 26 mM h(-1). Simulations showed that the errors caused by the intermittent measurement method were insignificant under the prevailing conditions.
Design and Calibration of Load Sensing Orthopaedic Implants (2008)

Contact forces and moments act on orthopaedic implants such as joint replacements. The three forces and three moment components can be measured by six internal strain gauges and wireless telemetric data transmission. The accuracy of instrumented implants is restricted by their small size, varying modes of load transfer, and the accuracy of calibration. Aims of this study were to test with finite element studies design features to improve the accuracy, to develop simple but accurate calibration arrangements, and to select the best mathematical method for calculating the calibration constants. Several instrumented implants, and commercial and test transducers were calibrated using different loading setups and mathematical methods. It was found that the arrangement of flexible elements such as bellows or notches between the areas of load transfer and the central sensor locations is most effective to improve the accuracy. Increasing the rigidity of the implant areas, which are fixed in bones or articulate against joint surfaces, is less effective. Simple but accurate calibration of the six force and moment components can be achieved by applying eccentric forces instead of central forces and pure moments. Three different methods for calculating the measuring constants proved to be equally well suited. Employing these improvements makes it possible to keep the average measuring errors of many instrumented implants below 1–2% of the calibration ranges, including cross talk. Additional errors caused by noise of the transmitted signals can be reduced by filtering if this is permitted by the sampling rate and the required frequency content of the loads.
The standard of care: legal history and definitions: the bad and good news. (2011)

The true meaning of the term "the standard of care" is a frequent topic of discussion among emergency physicians as they evaluate and perform care on patients. This article, using legal cases and dictums, reviews the legal history and definitions of the standard of care. The goal is to provide the working physician with a practical and useful model of the standard of care to help guide daily practice.
Suppressive effects of transforming growth factor-beta1 produced by hepatocellular carcinoma cell lines on interferon-gamma production by peripheral blood mononuclear cells. (2002)

Transforming growth factor-beta1 (TGF-beta1) exerts potent immunosuppressive effects. In this study, we investigated the potential role of TGF-beta1 produced by hepatocellular carcinoma (HCC) cell lines in immunosuppression mechanisms. Using the Mv1Lu cell-growth inhibition assay and an enzyme-linked immunosorbent assay (ELISA), we detected optimal levels of TGF-beta1 in the culture supernatants conditioned by the HCC cell lines PLC/PRF/5, Hep3B, and HepG2. To determine the biological activity of TGF-beta1 in the supernatants, we examined the effects of the culture supernatants on the production of interferon (IFN)-gamma induced during the culture of peripheral blood mononuclear cells (PBMCs) stimulated with interleukin (IL)-12. IFN-gamma production of IL-12-stimulated PBMCs in the 1:1 dilution of the acid-activated conditioned medium of PLC/PRF/5, Hep3B, and HepG2 reduced to 14.7 +/- 0.8, 17.3 +/- 9.0, and 35.9 +/- 14.6%, respectively, compared with the value in the culture with control medium (complete culture medium). These results suggest that HCC cells producing TGF-beta1 may reduce the generation or activation of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, and thus could enhance their ability to escape immune-mediated surveillance.
Sulfuric acid baking and leaching of spent sulfuric acid catalyst (2011)

Vanadium, iron and aluminum were recovered from the spent sulfuric acid catalyst with efficiency of 98%, 95% and 85%, respectively by using low temperature sulphuric acid baking followed by leaching. The optimum baking conditions were four grams of concentrated sulfuric acid per ten grams of spent catalyst at 300 ^\circ C for two hours. Sulphuric acid baking followed by leaching was found to be the best and it is more effective in Iron and Aluminum dissolution. Sulfuric acid baking is expected to consume small amount of chemicals and generate much less waste effluents during the separation process of metals with alkali solutions. It is economically favorable, as it avoids us much more environmental contamination.
Potential Energy Savings Due to Phase Change Material in a Building Wall Assembly: An Examination of Two Climates (2012)

Phase change material (PCM), placed in an exterior wall, alters the temperature profile within the wall and thus influences the heat transport through the wall. This may reduce the net energy transport through the wall via interactions with diurnal temperature swings in the external environment or reduce the electricity needed to meet the net load through the wall by shifting the time of the peak load to a time when the cooling system operates more efficiently. This study covers a broad range of parameters that can influence the effectiveness of such a merged thermal storage-thermal insulation system. These parameters included climate, PCM location within the wall, amount of PCM, midpoint of the PCM melting and freezing range relative to the indoor setpoint temperature, temperature range over which phase change occurs, and the wall orientation. Two climates are investigated using finite difference and optimization analyses: Phoenix and Baltimore, with two utility rate schedules. Although potential savings for a PCM with optimized properties were greater when the PCM was concentrated near the inside wall surface, other considerations described here lead to a recommendation for a full-thickness application. An examination of the temperature distribution within the walls also revealed the potential for this system to reduce the amount of energy transported through the wall framing. Finally, economic benefits can exceed energy savings when time-of-day utility rates are in effect, reflecting the value of peak load reductions for the utility grid.
Direct Measurements of Endothelium-Derived Nitric Oxide Release by Stimulation of Endothelin Receptors in Rat Kidney and Its Alteration in Salt-Induced Hypertension (1995)

These results suggest that ET-1 and ET-3 release EDNO via ETB receptors in renal vessels. ETB-mediated NO release was reduced in DOCA-salt rats, which may modulate renal function and thus blood pressure regulation in DOCA-salt hypertensive rats.
Eigenspace-based anomaly detection in computer systems (2004)

We report on an automated runtime anomaly detection method at the application layer of multi-node computer systems. Although several network management systems are available in the market, none of them have sufficient capabilities to detect faults in multi-tier Web-based systems with redundancy. We model a Web-based system as a weighted graph, where each node represents a "service" and each edge represents a dependency between services. Since the edge weights vary greatly over time, the problem we address is that of anomaly detection from a time sequence of graphs.In our method, we first extract a feature vector from the adjacency matrix that represents the activities of all of the services. The heart of our method is to use the principal eigenvector of the eigenclusters of the graph. Then we derive a probability distribution for an anomaly measure defined for a time-series of directional data derived from the graph sequence. Given a critical probability, the threshold value is adaptively updated using a novel online algorithm.We demonstrate that a fault in a Web application can be automatically detected and the faulty services are identified without using detailed knowledge of the behavior of the system.
Synthesis, characterization, and antimicrobial properties of copper nanoparticles (2013)

Copper nanoparticle synthesis has been gaining attention due to its availability. However, factors such as agglomeration and rapid oxidation have made it a difficult research area. In the present work, pure copper nanoparticles were prepared in the presence of a chitosan stabilizer through chemical means. The purity of the nanoparticles was authenticated using different characterization techniques, including ultraviolet visible spectroscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and field emission scanning electron microscopy. The antibacterial as well as antifungal activity of the nanoparticles were investigated using several microorganisms of interest, including methicillin-resistant Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Salmonella choleraesuis, and Candida albicans. The effect of a chitosan medium on growth of the microorganism was studied, and this was found to influence growth rate. The size of the copper nanoparticles obtained was in the range of 2-350 nm, depending on the concentration of the chitosan stabilizer.
A Novel Asymmetric Benzoin Reaction Catalyzed by a Chiral Triazolium Salt. Preliminary communication (1996)

Abstract Using the chiral triazolium salt 1 as catalyst, a novel asymmetric variant of the benzoin reaction is reported. For the first time, the scope of the method is extended to a broader range of aromatic aldehydes 2 , affording the acyloins 3a–h in yields of 22–72% and enantiomeric excesses up to 86%.
Improved variable ordering of BDDs with novel genetic algorithm (2002)

A new algorithm for variable ordering of binary decision diagram (BDD) is presented. The algorithm is based on a novel formulation of the Genetic Algorithm (GA) employing three dynamic GA parameters: population size, mutation rate and stop criteria. Test results using LGSynth93 benchmark circuits show that the new algorithm offers considerable improvements on large circuits when compared with previously published results.
Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of gag precursors and result in the release of noninfectious virus particles (1996)

The Cys-Xaa2-Cys-Xaa4-His-Xaa4-Cys zinc fingers of retroviral nucleocapsid proteins are prime antiviral targets because of conservation of the Cys and His chelating residues and the absolute requirement of these fingers in both early and late phases of retroviral replication. We previously reported that certain disulfide-substituted benzamides (DIBAs) chemically modify the Cys residues of the fingers, resulting in inhibition of human immunodeficiency virus type 1 (HIV-1) replication (W. G. Rice, J. G. Supko, L. Malspeis, R. W. Buckheit, Jr., D. Clanton, M. Bu, L. Graham, C. A. Schaeffer, J. A. Turpin, J. Domagala, R. Gogliotti, J. P. Bader, S. M. Halliday, L. Coren, R. C. Sowder II, L. O. Arthur, and L. E. Henderson, Science 270:1194-1197, 1995). We now examine the consequences of the interaction of DIBAs with the zinc fingers of the HIV-1 p7 nucleocapsid protein and its Pr55gag precursor. In HIV-1-infected U1 cells, DIBAs inhibited the release of infectious virions, and even under conditions in which virion particles were produced, the particles were noninfectious. DIBAs caused abnormal processing of Gag precursors, and the inhibitory effect on processing was not due to inhibition of the HIV-1 protease enzyme or Pr55gag myristoylation. Rather, the defect in processing was due to the formation of intermolecular cross-linkages among the zinc fingers of adjacent Gag molecules, rendering the precursors no longer recognizable by HIV-1 protease. Likewise, DIBAs caused intermolecular cross-linkage among recombinant Pr55gag packaged into pseudovirions, thereby generating modified precursors that were resistant to the action of protease. Thus, DIBAs chemically modified the mutationally intolerant retroviral zinc fingers in infected cells, interrupting protease-mediated maturation of virions and leading ultimately to the production of compromised virions.
Improvement of the dirt suspending power of CMC (1954)

Abstract The salts of carboxymethylcellulose (CMC) are used in large quantities to improve the dirt‐suspending power of synthetic detergents and soaps. Hardly any attention has been given to the question as to which properties they should have to obtain the greatest suspending power. They exert their specific influence because they are adsorbed by cellulose fibers from their solutions in water. Theoretical considerations are given, showing that: ( 1 ) The degree of substitution (DS) should probably be about 0.5. ( 2 ) The substitution should be as uniform as possible. ( 3 ) The cellulose chains should be neither too short nor too long. Normally only the average degree of substitution, DS, is determined. The fiber contents, FC, i.e. , the percentage of insoluble and partly swollen fibers in 1/20 N NaOH can be taken as a measure of the uniformity of the substitution. Technical products differ greatly in p H and salt contents; therefore the viscosity of solutions of the technical products containing 1% of the cellulose ether, to which 2.5% Na 2 CO 3 and 2.5% NaHCO 3 have been added, is taken as a measure of the length of the cellulose chains. The easiest way to obtain uniformly substituted products is by dispersing cellulose and reagents in a suspending liquid, e.g. , an alcohol or a hydrocarbon. FC's smaller than 2 to 4% are obtained. Then the dirt‐suspending power was greatest with a DS between 0.48 and 0.53; and a viscosity measured as above with a Hoeppler standard viscometer between 11 and 29 c.p.s. The substitution in general is much less uniform when CMC is prepared according to the customary method by mixing cellulose, NaOH, and ClCH 2 COONa or ClCH 2 COOH and a little water. Then the results were best with an average DS between 0.51 and 0.60, and an FC between 6 and 16%, said viscosity being 20 to 30 c.p.s.
Modified Beer-Lambert law for blood flow (2014)

We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues.
[Reduction of acute kidney transplantation rejection by the chemokine receptor antagonist Met-RANTES]. (1999)

Chemokines contribute to the mononuclear cell infiltrate in vessels and interstitium which is characteristic of renal transplant rejection. By employing the chemokine receptor blocker Met-RANTES it was shown that recruitment of inflammatory cells into renal allografts could be significantly suppressed. In a renal transplant model (Fisher RT1(1v1) rat kidney into Lewis RT1(1) rat) Met-RANTES-treated animals showed a significant reduction in vascular injury score (16.10 +/- 5.20 vs. 62.67 +/- 18.64) and tubular damage score (15.70 +/- 5.22 vs. 33.00 +/- 6.44) relative to untreated animals. In a severe rejection model (Brown-Norway RT1n rat kidney into Lewis RT1(1) rat), Met-RANTES significantly augmented low-dose cyclosporin A treatment to reduce all aspects of renal injury including interstitial inflammation (score 71.00 +/- 6.10 vs. 157.30 +/- 21.30). In a monocyte attachment assay on microvascular endothelium under physiological flow conditions exposure of microvascular endothelium to RANTES resulted in RANTES immobilization and RANTES-induced firm adhesion of monocytes only after prestimulation of the endothelium with IL-1 beta. Met-RANTES completely inhibited this RANTES-mediated arrest. Thus, Met-RANTES can reduce acute rejection by impeding leukocyte arrest to inflamed endothelium.
Detection of interest points using symmetry (2002)

An operator based on the intuitive motion of symmetry, which effectively locates interest points in real time and can be incorporated also in active visual systems, is introduced. The results of its operation agree with some psychophysical evidence concerning symmetry as well as evidence concerning fixation points. The operator can be applied successfully without prior knowledge of the world. Combining the operator with some preconceptions about the image is a powerful tool for feature detection in intricate natural scenes. The localization of faces and facial features in real time is demonstrated on detailed and noisy pictures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Optimal signal reconstruction in noisy filter bank systems: multirate Kalman synthesis filtering approach (1995)

A multirate Kalman synthesis filter is proposed in this paper to replace the conventional synthesis filters in a noisy filter bank system to achieve optimal reconstruction of the input signal. Based on an equivalent block representation of subband signals, a state-space model is introduced for an M-band filter bank system with subband noises. The composite effect of the input signal, analysis filter bank, decimators, and interpolators is represented by a multirate state-space model. The input signal is embedded in the state vector, and the corrupting noises in subband paths are generally considered as additive noises. Hence, the signal reconstruction problem in the M-band filter bank systems with subband noises becomes a state estimation procedure in the resultant multirate state-space model. The multirate Kalman filtering algorithm is then derived according to the multirate state-space model to achieve optimal signal reconstruction in noisy filter bank systems. Based on the optimal state estimation theory, the proposed multirate Kalman synthesis filter provides the minimum-variance reconstruction of the input signal. Two numerical examples are also included. The simulation results indicate that the performance improvement of signal reconstruction in noisy filter bank systems is remarkable.
Expression and posttranslational modification of class III β-tubulin during neuronal differentiation of P19 embryonal carcinoma cells (1996)

We have used a combination of immunofluorescence microscopy, northern blotting, ELISA, and isoelectric focusing to characterize the expression of neuronal Class III beta-tubulin in P19 embryonal carcinoma cells induced to differentiate along a neuronal pathway by retinoic acid. Following 48 h differentiation, beta-III tubulin mRNA is evident and beta-III tubulin appears in the mitotic spindle of neuroblasts. Neurite outgrowth is obvious by day 3, and beta-III tubulin protein and mRNA levels increase concurrently until approximately day 7, when beta-III mRNA levels begin to decrease while protein levels remain high. In addition, increasingly acidic beta-III tubulin isoforms appear during neuronal differentiation. The expression of these isoelectric variants occurs concomitant with a temporal increase in the levels of beta-III tubulin present in the colchicine-stable microtubules. These results implicate posttranslational modifications of beta-III tubulin in the increased microtubule stability noted in differentiating P19 neurons.