gebhart/patrepeval huggingface dataset:
Association after linkage analysis indicates that homozygosity for the 46C→T polymorphism in the F12 gene is a genetic risk factor for venous thrombosis (2004)

In a family-based study called GAIT (Genetic Analysis of Idiopathic Thrombophilia) that included a genome-wide scan we demonstrated that a polymorphism (46C-->T) in the F12 locus jointly influences variability of plasma (Factor XII) FXII levels and susceptibility to thrombotic disease. It then became germane to determine the prevalence of the 46C-->T polymorphism and its relative risk of thrombotic disease. We followed up evidence for genetic linkage with a case-control study, including 250 unrelated consecutive Spanish patients suffering from venous thrombotic disease and 250 Spanish subjects matched for sex and age as a controls. We measured FXII levels and genotyped the 46C-->T polymorphism, as well as a number of classical risk factors for thrombotic disease. We confirmed that individuals with different genotypes for this polymorphism showed significant differences in their FXII levels. Most importantly, the mutated T allele in the homozygous state (genotype T/T) was associated with an increased risk of thrombosis (adjusted OR of 4.82; 95% CI 1.5-15.6), suggesting that the polymorphism itself is an independent risk factor for venous thromboembolism. This study confirms that the 46C-->T polymorphism is a genetic risk factor for venous thrombosis in the Spanish population. In addition, our results confirm that a genome-wide scan coupled with a classical case-control association study is an extremely valuable approach to identify DNA variants that affect complex diseases.
Image-Guided Personalized Predictive Dosimetry by Artery-Specific SPECT/CT Partition Modeling for Safe and Effective <sup>90</sup>Y Radioembolization (2012)

Image-guided personalized predictive dosimetry by artery-specific SPECT/CT partition modeling achieves high clinical success rates for safe and effective (90)Y radioembolization.
Case 17-2000 (2000)

Presentation of CaseA 21-week-old girl was admitted to the hospital because of fever.The infant had been born by normal spontaneous vaginal delivery to a 37-year-old nulliparous woman after a full-term, uncomplicated pregnancy. The mother had endometritis after delivery. The infant's birth weight was 2840 g. All immunizations were up to date, and growth and development were normal.The infant was well until two weeks before admission (four weeks after having started to attend a day-care program), when fever developed. She was given acetaminophen, but her temperature rose to 38.3°C during the next several days. Ten days before admission . . .
Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models (2010)

Atu027 can be considered as a potent drug for preventing lung metastasis formation, which might be suitable for preventing hematogenous metastasis in addition to standard cancer therapy.
Variable Structure Control of Radar Servo System Based on IMM (2008)

The interacting multiple model (IMM) algorithm is mostly applied to state estimation of system whose characteristic changes by time. Itpsilas especially fit for the track of maneuvering object. By using the estimation of parameter in object movement, this paper presents variable structure control, based on IMM of servo system tracked by radar. The algorithm filters the controlled input signals, to decrease the noises and to reach the purpose of diminishing the buffeting. By making use of target angular speed and the state of angular acceleration which are estimated by algorithm, the dynamic hysteresis of servo system can be reduced. Simulation results show the effectiveness of the algorithm. And in practical engineering application, it has achieved good control.
Physiological and Transcriptomic Aspects of Urea Uptake and Assimilation in Arabidopsis Plants  (2008)

Urea is the major nitrogen (N) form supplied as fertilizer in agriculture, but it is also an important N metabolite in plants. Urea transport and assimilation were investigated in Arabidopsis (Arabidopsis thaliana). Uptake studies using (15)N-labeled urea demonstrated the capacity of Arabidopsis to absorb urea and that the urea uptake was regulated by the initial N status of the plants. Urea uptake was stimulated by urea but was reduced by the presence of ammonium nitrate in the growth medium. N deficiency in plants did not affect urea uptake. Urea exerted a repressive effect on nitrate influx, whereas urea enhanced ammonium uptake. The use of [(15)N]urea and [(15)N]ammonium tracers allowed us to show that urea and ammonium assimilation pathways were similar. Finally, urea uptake was less efficient than nitrate uptake, and urea grown-plants presented signs of N starvation. We also report the first analysis, to our knowledge, of Arabidopsis gene expression profiling in response to urea. Our transcriptomic approach revealed that nitrate and ammonium transporters were transcriptionally regulated by urea as well as key enzymes of the glutamine synthetase-glutamate synthase pathway. AtDUR3, a high-affinity urea transporter in Arabidopsis, was strongly up-regulated by urea. Moreover, our transcriptomic data suggest that other genes are also involved in urea influx.
Saturation Magnetizations of Iron Carbides<sup>1</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSaturation Magnetizations of Iron Carbides1L. J. E. Hofer and Ernst M. CohnCite this: J. Am. Chem. Soc. 1959, 81, 7, 1576–1582Publication Date (Print):April 1, 1959Publication History Published online1 May 2002Published inissue 1 April 1959https://pubs.acs.org/doi/10.1021/ja01516a016https://doi.org/10.1021/ja01516a016research-articleACS PublicationsRequest reuse permissionsArticle Views669Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Triterpenoids. Part 8. Structure Elucidation of New CrO3 and tert‐ Butyl Chromate Oxidation Products of Methyl Oleanolate and Some of Its Derivatives. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Image Analysis of 2D X-ray Intensity Maps: Element Abundances, Mineralogy, and Modal Analysis of Meteorites (2014)

X-ray mapping is increasingly used in the geological sciences for qualitative observations of textures, mineral zoning, and element distribution among rock components We combine mapping with an aggressive program of image analysis in deepening our understanding of the early solar system through the analysis of chondritic meteorites Chondrites are "sediments" that accreted in the earliest solar system into planetesimals now represented by objects in the asteroid belt. They accumulated hightemperature inclusions (igneous rock droplets or aggregations) with a low-temperature fine-grained mineral matrix including pre-solar grains and macromolecular carbon We seek to measure the relative abundances, modal mineralogies, and chemical compositions of these components with such different thermal histories, to higher accuracy than has been done previously.
Drug-eluting cements for hard tissue repair: A comparative study using vancomycin and RNPA1000 to inhibit growth of <i>Staphylococcus aureus</i> (2013)

Bone cement used in orthopaedic applications can become colonized with bacterial biofilms, resulting in severe medical complications. Consequently, bone cements are often loaded with antibiotics in an effort to prevent bacterial colonization. However, current formulations may not release antibiotics into the environment at sufficient and sustained concentrations required to impede bacterial growth or may be incompatible with antibiotics that are effective against the colonizing organism. Thus, new cement formulation options are needed. This report describes the performance of a novel SiO2-TiO2-ZnO-CaO-SrO-based glass polyalkenoate cement as a carrier of antimicrobials active against Staphylococcus aureus, the predominant cause of orthopaedic biofilm-associated infections. The antibiotic vancomycin and a novel Staphylococcus aureus RnpA inhibitor under pre-clinical development, RNPA1000, were included in these studies. Rheological testing characterized the workability of the glass polyalkenoate cement over a range of powder-to-liquid ratios and polyacrylic acid concentrations and revealed that the most suitable powder-to-liquid ratio was 2/1.25 with 40 wt% polyacrylic acid. Loading glass polyalkenoate cement with either 20-30% RNPA1000 or vancomycin prevented bacterial growth. However, longer incubations allowed for Staphylococcus aureus colonies to form near the vancomycin-infused cement, indicating that vancomycin may not be suitable for long-term biofilm inhibition in comparison to RNPA1000. Scanning electron microscopy and energy-dispersive X-ray analyses confirmed successful incorporation RNPA1000 into the cement matrix and were indicative of its slow release. These studies establish a drug-eluting formulation of glass polyalkenoate cement with great potential in orthopaedic implants that incorporates known antibiotics as well as RNPA1000 to prevent growth of the dangerous pathogen Staphylococcus aureus.
A continuation method for emission tomography (1993)

The authors describe a continuation method in which the minimum of the energy function corresponding to one member of the Phi function sequence is used as an initial condition for the minimization of the next, less approximate, stage. This continuation method is implemented using a GEM-ICM (generalized expectation maximization-iterated conditioned mode) procedure. Simulation results show improvement using this continuation method relative to using Phi * alone, and to conventional EM reconstructions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
EPC-Synthesis of β-Amino Acid Derivatives through Lithiated Hydropyrimidines (1999)

Racemic and enantiopure 2-tert-butyltetrahydropyrimidinones (from pivalaldehyde and 3-aminocarboxylic acids) are converted to Alloc-, Boc-, and Z-protected cyclic imino esters (7–10, Schemes 2–4). These are deprotonated to Li enaminates (K, L). Reactions with electrophiles (prim., sec. alkyl, allyl, benzyl, propargyl halides, aldehydes, imines, enoates) give good yields and are highly diastereoselective (products 11–42, Schemes 5–10). A two-step cleavage (removal of protecting group and hydrolysis) under very mild conditions converts the heterocyclic products to α-branched β-amino acid methyl esters (43–61, Schemes 11–13). The structure of the products is determined by NMR spectroscopy (Figure 1), by chemical correlation (Scheme 14), and by X-ray analysis (Figure 2, 3, 7, Table 1). A structure of the Li enaminates is proposed (Figure 4). Mechanistic models are derived for the reactions occurring with formation of two stereogenic centers with relative topicity like (Figures 5, 6).
THE PATHOGENESIS OF CHRONIC INFLAMMATION IN EXPERIMENTAL ANTIGEN-INDUCED ARTHRITIS (1972)

In an experimental arthritis induced by injection of bovine serum albumin or egg albumin into the joints of previously immunized animals, it has been demonstrated that the major portion of the radioactively labeled antigens injected was localized to avascular collagenous tissues in the joint, i.e., articular cartilage, menisci, and intra-articular ligaments. The antigens were partially eluted from the tissues with 5 M guanidine solution, but not with acid buffers or by 3 M magnesium chloride. The radioactive material eluted with guanidine was at least 80% precipitable by specific antisera. The radioactively labeled-inducing antigen was identified on the surface of articular collagenous tissues from arthritic joints by radioautography and immunofluorescence. Rabbit immunoglobulin and C3 were demonstrated in the same sites by immunofluorescence. The presence of specific antibody in collagenous tissues was demonstrated by the selective in vitro binding of (125)I-labeled-inducing antigen to menisci from arthritic joints of immunized animals. The evidence obtained indicates that in this model of chronic arthritis, the inducing antigen persists for long periods of time in the form of immune complexes in the surface layers of the intra-articular collagenous tissue. The antigen retained in this form may be responsible for the chronicity of the synovitis by serving as a direct stimulus for the maintenance of prolonged antibody synthesis in the synovium and by providing a source of complement-fixing antigen-antibody complexes for the mediation of joint inflammation.
Entacapone and Tolcapone, Two Catechol O-Methyltransferase Inhibitors, Block Fibril Formation of α-Synuclein and β-Amyloid and Protect against Amyloid-induced Toxicity (2010)

. There is considerable consensus that the increased production and/or aggregation of -synuclein (-syn) plays a central role in the pathogenesis of PD and related synucleinopathies. Current therapeutic strategies for treating PD offer mainly transient symptomatic relief and aim at the restitution of dopamine levels to counterbalance the loss of dopaminergic neurons. Therefore, the identification and development of drug-like molecules that block -synuclein aggregation and prevent the loss of dopaminergic neurons are desperately needed to treat or slow the progression of PD. Here, we show that entacapone and tolcapone are potent inhibitors of -syn and -amyloid (A) oligomerization and fibrillogenesis, and they also protect against extracellular toxicity induced by the aggregation of both proteins. Comparison of the anti-aggregation properties of entacapone and tolcapone with the effect of five other catechol-containing compounds, dopamine, pyrogallol, gallic acid, caffeic acid, and quercetin on the oligomerization and fibrillization of -syn and A, demonstrate that the catechol moiety is essential for the antiamyloidogenic activity. Our findings present the first characterization of the anti-amyloidogenic properties of tolcapone and entacapone against both -synuclein and A42 and highlight the potential of this class of nitro-catechol compounds as antiamyloidogenic agents. Their inhibitory properties, mode of action, and structural properties suggest that they constitute promising lead compounds for further optimization.
Conservation and Variability of Dengue Virus Proteins: Implications for Vaccine Design (2008)

Forty-four (44) pan-DENV sequences of at least 9 amino acids were highly conserved and identical in 80% or more of all recorded DENV sequences, and the majority were found to be immune-relevant by their correspondence to known or putative HLA-restricted T-cell determinants. The conservation of these sequences through the entire recorded DENV genetic history supports their possible value for diagnosis, prophylactic and/or therapeutic applications. The combination of bioinformatics and experimental approaches applied herein provides a framework for large-scale and systematic analysis of conserved and variable sequences of other pathogens, in particular, for rapidly mutating viruses, such as influenza A virus and HIV.
Efficient XML Interchange in factory automation systems (2011)

The advent of Service-Oriented Architecture (SOA) in the automation domain has made possible the cross-layer vertical integration of devices, manufacturing systems and business processes. However, the use of standard web service technologies is not always possible in an industrial environment with high real-time requirements and limited hardware resources due to the overhead connected to XML processing. The work presented in this paper analyses the opportunities, advantages and challenges when applying the newly emerged Efficient XML Interchange (EXI) standard for XML encoding to the factory automation systems. The two major SOA-based automation middleware architectures, namely OPC Unified Architecture (OPC UA) and Devices Profile for Web Services (DPWS), were investigated. Furthermore, we present an EXI-based approach for extending the reach of the service technology covering deployments on resource constrained embedded devices.
Characterization of the Extra-large G Protein α-Subunit XLαs (2000)

Our group previously described a new type of G protein, the 78-kDa XLalphas (extra large alphas) (Kehlenbach, R. H., Matthey, J., and Huttner, W. B. (1994) Nature 372, 804-809 and (1995) Nature 375, 253). Upon subcellular fractionation, XLalphas labeled by ADP-ribosylation with cholera toxin was previously mainly detected in the bottom fractions of a velocity sucrose gradient that contained trans-Golgi network and was differentially distributed to Galphas, which also peaked in the top fractions containing plasma membrane. Here, we investigate, using a new antibody specific for the XL domain, the tissue distribution and subcellular localization of XLalphas and novel splice variants referred to as XLN1. Upon immunoblotting and immunofluorescence analysis of various adult rat tissues, XLalphas and XLN1 were found to be enriched in neuroendocrine tissues, with a particularly high level of expression in the pituitary. By both immunofluorescence and immunogold electron microscopy, endogenous as well as transfected XLalphas and XLN1 were found to be predominantly associated with the plasma membrane, with only little immunoreactivity on internal, perinuclear membranes. Upon subcellular fractionation, immunoreactive XLalphas behaved similarly to Galphas but was differentially distributed to ADP-ribosylated XLalphas. Moreover, the bottom fractions of the velocity sucrose gradient were found to contain not only trans-Golgi network membranes but also certain subdomains of the plasma membrane, which reconciles the present with the previous observations. To further investigate the molecular basis of the association of XLalphas with the plasma membrane, chimeric proteins consisting of the XL domain or portions thereof fused to green fluorescent protein were analyzed by fluorescence and subcellular fractionation. In both neuroendocrine and non-neuroendocrine cells, a fusion protein containing the entire XL domain, in contrast to one containing only the proline-rich and cysteine-rich regions, was exclusively localized at the plasma membrane. We conclude that the physiological role of XLalphas is at the plasma membrane, where it presumably is involved in signal transduction processes characteristic of neuroendocrine cells.
hnRNP-K and Purα act together to repress the transcriptional activity of the CD43 gene promoter (2002)

CD43 is an abundant, heavily glycosylated molecule expressed specifically on the surface of leukocytes and platelets. When leukocytes are at rest, CD43 acts to prevent both homotypic and heterotypic interactions. However, during leukocyte activation CD43 expression is repressed, facilitating the intercellular contact required for chemotaxis, phagocytosis, aggregation, adhesion to endothelium, and transendothelial migration. Consequently, CD43 repression plays a vital role both in innate and acquired immunity. Here we report that a dramatic down-regulation of CD43 mRNA levels occurs during activation of the leukocytic cell line K562. This repression coincides with repression of the transcriptional activity of the CD43 gene promoter. We have determined that heterogeneous nuclear ribonucleoprotein K (hnRNP-K) and Pur(alpha) act together to mediate repression of the CD43 promoter during K562 activation. The hnRNP-K molecule and Pur(alpha) bind single-stranded DNA. Therefore, exposure of single-stranded structures within the CD43 promoter probably plays a major role in effecting CD43 repression.
Release of Oligosaccharides from Human Erythrocyte Membranes of Different Blood-Group-P Phenotypes by Trifluoroacetolysis (1980)

Human erythrocyte membranes of different blood-group-P phenotypes have been degraded by trifluoroacct olysis at conditions that will effect transamidation. This degradation resulted in dissolution of the membranes with concomitant degradation of proteins. Oligosaccharide chains linked to proteins and ceramides were released as their pertrifluoroacetylated derivatives, which generally are stable towards further action of the reagent. 2-Acetamido-2-deoxy-sugar residues were converted into their corresponding 2-deoxy-2-trifluoroacetamido derivatives. The mixture of pertrifluoroacetylated oligosaccharides obtained was de-O-trifluoroacetylated and de-N-trifluoroacetylated, reduced, acetylated, permethylated and analyzed by gas-liquid chromatography/mass spectrometry. Membranes obtained from two individuals with phenotype B, p̄ (known to contain an excess of lactosyl ceramide) gave almost identical results with lactose released as the main component. From AZB, Pk1 cell membranes small amounts of lactose were obtained but the trisaccharide Gal(α1-4)Gal(β1-4)Glc was the major component found. This trisaccharide is most likely derived from the Pk antigen (trihexosyl ceramide). Membranes from a donor with the phenotype B.P1 yielded small amounts of both lactose and the Pk trisaccharide together with a larger quantity of the tetrasaccharide GalNAc(β1-3)Gal(α1-4)Gal(β1-4)Glc. The tetrasaccharide represents the carbohydrate portion of the P antigen (globoside). From all three types of membranes the B-specific trisaccharide Gal(α1-3)Gal was obtained. This compound is probably derived from specific degradation of blood-group-B-active glycoproteins and/or glycolipids. In addition to the oligo-saccharides mentioned above a large number of others were observed but in lower amounts.
Locating functional errors in logic circuits (1989)

In the verification phase of the design of logic circuits using the top-down approach, it is necessary not only to detect but also to locate the source of any inconsistencies that may exist between the functional-level description and its gate-level implementation. In this paper we present a method that determines the areas, within the gate-level circuit, that contain the functional errors. The indicated areas are shown to have sufficient resolution to allow the designer to quickly find the cause of the inconsistency and, therefore, reduce the time required for debugging.
The role of excess arsenic in interface mixing in low-temperature-grown AlAs/GaAs superlattices (1995)

Undoped low-temperature-grown AlAs/GaAs superlattices experience pronounced interface intermixing with increasing anneal temperatures up to 900 °C. Quantum confinement shifts caused by intermixing of low-temperature-grown and standard-temperature-grown superlattices were studied using electromodulation spectroscopy. The effective activation energy for intermixing in the low-temperature-grown superlattices during 30 s isochronal postgrowth anneals was found to be (0.32±0.04) eV, anomalously smaller than for standard-temperature-grown superlattices. Roughening of the interfaces caused by arsenic precipitates accompanies the intermixing. Qualitative features of the intermixing have been confirmed using high resolution transmission electron microscopy and studies on x-ray rocking curves.