gebhart/patrepeval huggingface dataset:
Nuclear envelope disassembly in mitotic extract requires functional nuclear pores and a nuclear lamina (1998)

Using sea urchin embryonic and in-vitro-assembled nuclei incubated in sea urchin mitotic extract, I provide evidence for a requirement for functional nuclear pores and a nuclear lamina for nuclear envelope disassembly in vitro. In interphase gastrula nuclei, lamin B interacts with p56, an integral protein of inner nuclear membrane cross-reacting with antibodies to human lamin B receptor. Incubation of gastrula nuclei in mitotic cytosol containing an ATP-generating system rapidly induces hyperphosphorylation of p56 and lamin B. Subsequently, p56-lamin B interactions are weakened and the two proteins segregate into distinct nuclear envelope-derived vesicles upon disassembly of nuclear membranes and of the lamina. Nuclear disassembly is accompanied by chromatin condensation. Blocking nuclear pore function with wheat germ agglutinin or antibodies to nucleoporins prevents p56 and lamin B hyperphosphorylation, nuclear membrane breakdown and lamina solubilization. These events are not rescued by permeabilization of nuclear membranes to molecules of 150, 000 Mr with lysolecithin. In-vitro-assembled nuclei containing nuclear membranes with functional pores but no lamina do not disassemble in mitotic cytosol in spite of p56 hyperphosphorylation. Nuclear import of soluble lamin B and reformation of a lamina in interphase extract restores nuclear disassembly in mitotic cytosol. The data indicate a role for functional nuclear pores in nuclear disassembly in vitro. They show that p56 hyperphosphorylation is not sufficient for nuclear membrane disassembly in mitotic cytosol and argue that the nuclear lamina plays a critical role in nuclear disassembly at mitosis.
Monitoring Neuromuscular Transmission (2002)

Persistent neuromuscular blockade is not uncommon in the recovery room and contributes to postoperative morbidity and possibly mortality. The use of neuromuscular monitoring and intermediate rather than long-acting neuromuscular blocking drugs have been shown to reduce its incidence. Clinically available methods of detecting and quantitating neuromuscular blockade are reviewed. The writer concludes that such monitoring should be routine when neuromuscular blocking drugs are used.
Isolated Mitochondrial Myopathy Associated With Muscle Coenzyme Q10 Deficiency (2005)

The absence of central nervous system involvement and recurrent myoglobinuria expands the clinical phenotype of this treatable mitochondrial disorder. The complete recovery of myopathy with exogenous CoQ(10) supplementation observed in this patient highlights the importance of early identification and treatment of this genetic disorder.
Dioxygen Oxidation of Alcohols and Aldehydes Over a Cerium Dioxide-Ruthenium System (1998)

Abstract Treatment of cerium dioxide with small amounts of RuCl3. 3H2O allows the mild preparation of an efficient heterogeneous system for the dioxygen oxidation of various alcohols and aldehydes.
The effect of sputtered-SiO&lt;inf&gt;2&lt;/inf&gt;facet coating films on the suppression of self-sustained pulsations in the output of (GaAl)As double-heterostructure lasers during CW operation (1980)

In order to clarify the cause of self-sustained pulsation (SSP) associated with degradation, both channeled-substrate-planar and new buried-heterostructure lasers were life tested under various conditions. Surface layers at the laser mirrors, which probably included large nonradiative recombination centers, were etched off to a depth of 200-500 Å by Ar+ ion etching, then sputtered-SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> films were deposited on both mirrors without the laser chips being removed from the apparatus. Optical microscope observation for the mirrors of the aged lasers and electroluminescent patterns observed in the active layers revealed that the SSP was caused by a mechanism closely related to optically induced faults, such as <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\langle110\rangle</tex> oriented dark line defects, which formed a saturable absorption region in the interior of the laser near the mirror. Facet coating films formed with the above process were found to be quite helpful in suppressing the occurrence of SSP provided that power densities were kept less than the moderately high value of 0.6 MW/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (∼15 mW/facet).
Divalent cations modulate the activity of metabotropic glutamate receptors (2003)

Metabotropic glutamate receptors (mGluRs) and calcium receptors (CaR) are closely related G protein-coupled receptors (GPCRs). The similar structural and functional properties of mGluRs and CaRs include conserved amino acid residues involved in glutamate binding in mGluRs and Ca2+ binding in the CaR. Furthermore, recent findings have demonstrated that mGluRs can respond to high extracellular Ca2+ (Ca2+(o)) whereas CaR activity is potentiated by L-amino acids. We show that both mGluR1 and mGluR2 are activated by Ca2+(o) in the absence of glutamate in the extracellular media. This activation by Ca2+(o) is antagonized by Mg2+(o). Unlike the CaR, in which the intracellular carboxyl tail has been reported to be involved in Ca2+(o)-dependent activity, the carboxyl tail of mGluRs does not seem to play a role in mediating Ca2+(o) actions. On the other hand, we find that preservation of disulfide bonds in the N-terminal extracellular domain of mGluRs is essential for stimulation by Ca2+(o) as well as glutamate. Because the mGluR1 EC50 for Ca2+(o) is within the physiologic range of Ca2+ in the synaptic cleft, mGluR function is likely regulated by changes in divalent cations caused by synaptic activity under normal or pathologic conditions.
Surface‐enhanced Raman scattering study of the adsorption of the anthraquinone pigment alizarin on Ag nanoparticles (2004)

Abstract FT‐Raman and surface‐enhanced Raman scattering (SERS) spectroscopy were applied in the vibrational characterization and study of the adsorption and acidity behavior of the highly fluorescent anthraquinone dye alizarin on Ag colloids prepared by chemical reduction with hydroxylamine hydrochloride. The SERS spectra were obtained at different conditions of pH, excitation wavelength and pigment concentration in order to deduce the adsorption mechanism of this molecule. On the basis of the results found we propose an adsorption model for alizarin, which has a different acidic behavior on the metal surface to that in solution. On the metal the deprotonation order of the OH groups changes with respect to the aqueous solution, the OH in position 1 being the first to be ionized instead of that in position 2 as occurs in solution. The two main alizarin forms identified on the metal surface correspond to the mono‐ and dianionic alizarin species. Copyright © 2004 John Wiley & Sons, Ltd.
Flexible Two-Dimensional Square-Grid Coordination Polymers: Structures and Functions (2010)

Coordination polymers (CPs) or metal-organic frameworks (MOFs) have attracted considerable attention because of the tunable diversity of structures and functions. A 4,4'-bipyridine molecule, which is a simple, linear, exobidentate, and rigid ligand molecule, can construct two-dimensional (2D) square grid type CPs. Only the 2D-CPs with appropriate metal cations and counter anions exhibit flexibility and adsorb gas with a gate mechanism and these 2D-CPs are called elastic layer-structured metal-organic frameworks (ELMs). Such a unique property can make it possible to overcome the dilemma of strong adsorption and easy desorption, which is one of the ideal properties for practical adsorbents.
Electrical characteristics and reliability properties of metal-oxide-semiconductor field-effect transistors with ZrO2 gate dielectric (2007)

Metal-oxide-semiconductor capacitors and metal-oxide-semiconductor field-effect transistors with ZrO2 gate dielectric were fabricated. The time dependent dielectric breakdown (TDDB) of ZrO2 capacitors was studied. It was observed that the Weibull slopes were independent of the capacitor area. The Weibull slopes had no clear dependence on ZrO2 thickness. The TDDB of ZrO2 follows the E model. The activation energy Ea was linearly dependent on the electric field and the field acceleration parameter γ is independent of temperature.
List of editors. (2002)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
The proliferative response of peripheral blood mononuclear cells to streptokinase (1990)

In vitro proliferative PBM responses were investigated for 26 patients with and 5 patients without acute myocardial infarction. All patients were initially treated with streptokinase (1.5 MIU infused for 1 hour). Five weeks after the disease increased responses to streptokinase, PPD and PHA were seen; but only for streptokinase had original nonresponders become responders (7 out of 14 nonresponders). The increased responsiveness to streptokinase could be detected five days after antigen infusion, and CD-2 positive cells constituted a major part of the proliferating PBM population. The responses after antigen infusion varied within a wide range both for patients with and without myocardial infarction.
A high proportion of blue light increases the photosynthesis capacity and leaf formation rate of <i>Rosa</i> × <i>hybrida</i> but does not affect time to flower opening (2012)

Alterations in light quality affect plant morphogenesis and photosynthetic responses but the effects vary significantly between species. Roses exhibit an irradiance‐dependent flowering control but knowledge on light quality responses is scarce. In this study we analyzed, the responses in morphology, photosynthesis and flowering of Rosa × hybrida to different blue (B) light proportions provided by light‐emitting diodes ( LED , high B 20%) and high pressure sodium ( HPS , low B 5%) lamps. There was a strong morphological and growth effect of the light sources but no significant difference in total dry matter production and flowering. HPS ‐grown plants had significantly higher leaf area and plant height, yet a higher dry weight proportion was allocated to leaves than stems under LED . LED plants showed 20% higher photosynthetic capacity (A max ) and higher levels of soluble carbohydrates. The increase in A max correlated with an increase in leaf mass per unit leaf area, higher stomata conductance and CO 2 exchange, total chlorophyll (Chl) content per area and Chl a/b ratio. LED ‐grown leaves also displayed a more sun‐type leaf anatomy with more and longer palisade cells and a higher stomata frequency. Although floral initiation occurred at a higher leaf number in LED , the time to open flowers was the same under both light conditions. Thereby the study shows that a higher portion of B light is efficient in increasing photosynthesis performance per unit leaf area, enhancing growth and morphological changes in roses but does not affect the total Dry Matter ( DM ) production or time to open flower.
Intestinal absorption of macromolecules during viral enteritis: an experimental study on rotavirus-infected conventional and germ-free mice. (1987)

Epithelial transport and degradation of horseradish peroxidase (HRP), a macromolecular tracer, was studied in conventional and germ-free suckling mice following an experimental infection with rotavirus. Conventional and germ-free mice developed diarrhea from days 2 to 8 postinfection (pi), with growth failure. In mucosal homogenates, infectious virus detected by immunofluorescence on MA 104 cells was present from day 2 through day 8 pi in germ-free mice, but persisted longer (day 13 pi) in conventional mice. Only mild histological lesions were observed during diarrhea, but obvious macrovacuolation of epithelial cells and increased cellular density occurred during the convalescence period (days 9 to 13 pi). Intact and degraded HRP fluxes from mucosa to serosa were measured in vitro on segments of jejunum mounted in Ussing chambers. Both groups of mice developed increased HRP permeability during the experimental period, but at different times after inoculation: during the diarrheal period (days 2 and 3 pi) conventional mouse epithelium absorbed five times more HRP than noninfected controls and during the convalescence period (days 9 to 13 pi) HRP absorption in germ-free mice rose 10-fold as compared to its level before infection. In both cases, this increase in HRP permeability was entirely due to an increase in intact HRP absorption, probably via a transcellular route, and occurred without any alteration in degraded HRP transport. These results indicate that in mice, rotavirus infection causes a transient rise in gut permeability to undegraded proteins. The intestinal microflora seems to affect the timing, magnitude, and duration of this increased permeability.
Decreased HLA‐A expression in prostate cancer is associated with normal allele dosage in the majority of cases (2000)

A comparison has been made of the phenotypic expression of MHC class I antigens with the corresponding HLA-A genotype in 15 cases of benign prostatic hyperplasia (BPH) and 34 cases of primary locally invasive prostatic carcinoma. Expression of class 1 protein, detected by immunocytochemistry, was partially or completely lost in approximately 90% of the tumours examined. Comparative genomic analysis of the beta2 microglobulin (beta2m) gene and 15 individual HLA-A haplotypes using a polymerase chain reaction (PCR)-based method demonstrated abnormal gene dosage in the minority of cases: homozygous deletion of the beta2m locus was detected in one case and HLA-A allele in two cases (HLA-A1 and HLA-A2, respectively), representing approximately 8% of the population studied. This first comparative study of gene dosage and expression of class 1 protein reported for prostate cancer reveals that deletion is not the cause of the partial or complete loss seen in the majority of cases. This raises the possibility, in the future, for novel selective immunomodulatory therapeutic strategies which stimulate a clinically significant re-expression of class 1 protein and associated cytotoxic T-cell response.
A cluster based architecture for intersection collision avoidance using heterogeneous networks (2013)

With the popularity of wireless devices, the possibility of implementing vehicular safety applications has been studied for years in the context of vehicular ad-hoc networks. Dedicated Short Range Communication (DSRC) is designed to serve the needs of vehicular safety applications. However, DSRC does not offer good enough coverage and range around intersections in urban areas for certain applications such as intersection collision avoidance. Considering these drawbacks, LTE, an advanced cellular communication technology, is proposed as an alternative to DSRC. One problem is LTE bandwidth capability to support regularly transmitted cooperative awareness messages. In this paper, we propose a cluster based architecture using both Wi-Fi and LTE channels to accomplish this task. In our architecture, Wi-Fi peer to peer channels are used for cluster formation while LTE channels are used for transmitting Cooperative Awareness Messages (CAMs). A clustering algorithm specifically designed for intersection collision avoidance service is proposed in this paper. In addition, a channel allocation algorithm is applied to reduce the interference of Wi-Fi channels between different clusters. Simulations show that CAM traffic can be efficiently supported in this architecture.
Electrostatic digital micromirror using interdigitated cantilevers (2003)

We have proposed an electrostatic digital micromirror utilizing interdigitated cantilevers. The electrostatically-actuated microstructure has been fabricated by the electroplated-nickel surface micromachining. Thanks to the unique design of the interdigitated cantilevers, the micromirror has an operational mechanism of a seesaw allowing accurate, reliable control of the final rotating angle. The fabricated digital micromirror has shown the rotating angle of /spl plusmn/9 degrees with an actuation voltage of 60 V.
Microscopic Social Influence (2012)

Social influences, the phenomena that one individual's actions can induce similar behaviors among his/her friends via their social ties, have been observed prevailingly in socially networked systems. While most existing work focuses on studying general, macro-level influence (e.g., diffusion); equally important is to understand social influence at microscopic scales (i.e., at the granularity of single individuals, actions, and time-stamps), which may benefit a range of applications. We propose μSI, a microscopic social-influence model wherein: individuals' actions are modeled as temporary interactions between social network (formed by individuals) and object network (formed by targets of actions); one individual's actions influence his/her friends in a dynamic, network-wise manner (i.e., dependent on both social and object networks). We develop for μSI a suite of novel inference tools that enable to answer questions of the form: How may an occurred interaction trigger another? More importantly, when and where may a new interaction be observed? We carefully address the computational challenges for inferencing over such semantically rich models by dynamically identifying sub-domains of interest and varying the precision of solutions over different sub-domains. We demonstrate the breadth and generality of μSI using two seemingly disparate applications. In the context of social tagging service, we show how it can help improve the accuracy and freshness of resource recommendation; in the context of mobile phone call service, we show how it can help improve the efficiency of paging operation.
A Staining Technique for the Study of Two‐Dimensional Dopant Diffusion in Silicon (1988)

Un melange de sulfate cuivrique (CuSO 4 •5H 2 O) dans l'acide fluorhydrique sert de solution de coloration, par depot de cuivre sur le type n par une reaction d'oxydoreduction
Performance of the rebuilt SUERC single-stage accelerator mass spectrometer (2015)

The SUERC bipolar single-stage accelerator mass spectrometer (SSAMS) has been dismantled and rebuilt to accommodate an additional rotatable pre-accelerator electrostatic spherical analyser (ESA) and a second ion source injector. This is for the attachment of an experimental positive-ion electron cyclotron resonance (ECR) ion source in addition to a Cs-sputter source. The ESA significantly suppresses oxygen interference to radiocarbon detection, and remaining measurement interference is now thought to be from 13C injected as 13CH molecule scattering off the plates of a second original pre-detector ESA.
Antigenic heterogeneity of lipopolysaccharide among Burkholderia pseudomallei clinical isolates. (2000)

Burkholderia pseudomallei (BP) causes melioidosis, a potentially fatal human infection in the tropics. Clinical isolates from different geographical locations have similar morphological and biochemical characteristics. Although BP has been reported to possess 2 types of lipopolysaccharide (LPS) differing in the chemical structure of their O-polysaccharide (O-PS) component, earlier report demonstrated that the clinical strains exhibited identical LPS moieties. Recently, we reported antigenic similarity between the pathogenic (Ara-) and nonpathogenic (Ara+) biotypes. However, a few clinical isolates showed atypical SDS-PAGE profiles. In this study, LPS from 739 BP isolated from patients and animals in different geographical areas were extracted by proteinase K digestion method. Their SDS-PAGE profiles and their immunoreactivities with patients' sera and monoclonal antibody (MAb) to LPS were analyzed. The isolates showed 3 LPS patterns differing in the number and electrical mobility of bands in silver-stained gel. A majority of BP (711) isolates exhibited identical typical ladder pattern, 21 isolates showed atypical ladder pattern and 7 isolates did not exhibit ladder appearance. However, all LPS preparations exhibited similar endotoxic activity as determined by Limulus amebocyte lysate assay. On the other hand, there were no immunological cross reactivity between typical and atypical LPS, as judged from Western blot against homologous and heterologous sera from melioidosis patients from whom the typical and atypical LPS were isolated. Nevertheless, a Western blot profile of the typical LPS showed some variations when probed with MAb against BP LPS (9D5). Heat-killed bacteria from all LPS groups could similarly activate mouse macrophage cell line to produce nitric oxide (NO) and inducible NO synthase (iNOS).
Enhanced CHISEL programming in flash memory devices with SiGe buried layer (2005)

A buried SiGe layer is used to increase the secondary impact ionization (SII) rate and therefore enhance the channel-initiated secondary electron (CHISEL) gate current in NOR flash electrically erasable and programmable read-only memory (EEPROM) devices. Electrical characterization of planar flash cells with a nanocrystal quantum dot floating gate shows a greater than 3/spl times/enhancement in the CHISEL component of the threshold voltage shift for devices with the SiGe layer compared to devices without.
Supersonic aircraft drag reduction (1990)

This paper reviews aerodynamic drag reduction for friction, wave and vortex drag associated with supersonic cruise aircraft and suggests approaches and research directions. Suction laminar flow control may also enable improved low-speed, high-lift systems, improved lift-to-drag ratio for subsonic cruise, reduced parasitic viscous drag for favorable interference wave drag reduction approaches, and turbulent skin friction reduction via slot injection. Flow separation control at cruise proffers opportunities for increased leading-edge thrust, increased lift increment from upper surface, increased fuselage lift/camber for wave drag-due-to-lift reduction, improved performance of various favorable interference wave drag reduction schemes, as well as possibly better low-speed, high-lift systems and wing cruise performance.
The tops in flops (2011)

Supercomputers are now running our search engines and social networks.Modern supercomputers are based on groups of tightly interconnected microprocessors. In recent years, supercomputers have shaped our daily lives more directly.
Analysis and improvement of a strongly secure certificateless key exchange protocol without pairing (2012)

Recently, Yang and Tan proposed a certificateless key exchange protocol without pairing, and claimed their scheme satisfies forward secrecy, which means no adversary could derive an already-established session key unless the full user secret keys (including a private key and an ephemeral secret key) of both communication parties are compromised. However, in this paper, we point out their protocol is actually not secure as claimed by presenting an attack launched by an adversary who has learned the private key of one party and the ephemeral secret key of the other, but not the full user secret keys of both parties. Furthermore, to make up this flaw, we also provide an improved protocol in which the private key and the ephemeral secret key are closely intertwined with each other for generating the session key, thus above attack can be efficiently resisted.