gebhart/patrepeval huggingface dataset:
Moonshine: Diurnally varying hydration through natural distillation on the Moon, detected by the Lunar Exploration Neutron Detector (LEND) (2015)

The Lunar Exploration Neutron Detector (LEND), on the polar-orbiting Lunar Reconnaissance Orbiter (LRO) spacecraft, has detected suppression in the Moon's naturally-occurring epithermal neutron leakage flux that is consistent with the presence of diurnally varying quantities of hydrogen in the regolith near the equator. Peak hydrogen concentration (neutron flux suppression) is on the dayside of the dawn terminator and diminishes through the dawn-to-noon sector. The minimum concentration of hydrogen is in the late afternoon and dusk sector. The chemical form of hydrogen is not determinable from these measurements, but other remote sensing methods and anticipated elemental availability suggest water molecules or hydroxyl ions. Signal-to-noise ratio at maximum contrast is 5.6<i>σ</i> in each of two detector systems. Volatiles are deduced to collect in or on the cold nightside surface and distill out of the regolith after dawn as rotation exposes the surface to sunlight. Liberated volatiles migrate away from the warm subsolar region toward the nearby cold nightside surface beyond the terminator, resulting in maximum concentration at the dawn terminator. The peak concentration within the upper ~1 m of regolith is estimated to be 0.0125 ± 0.0022 weight-percent water-equivalent hydrogen (wt% WEH) at dawn, yielding an accumulation of 190 ± 30 ml recoverable water per square meter of regolith at each dawn. Volatile transport over the lunar surface in opposition to the Moon's rotation exposes molecules to solar ultraviolet radiation. The short lifetime against photolysis and permanent loss of hydrogen from the Moon requires a resupply rate that greatly exceeds anticipated delivery of hydrogen by solar wind implantation or by meteoroid impacts, suggesting that the surface inventory must be continually resupplied by release from a deep volatile inventory in the Moon. The natural distillation of water from the regolith by sunlight and its capture on the cold night surface may provide energy-efficient access to volatiles for in situ resource utilization (ISRU) by direct capture before volatiles can enter the surface, eliminating the need to actively mine regolith for volatile resource recovery.
Evaluation of Detergent Enzymes in Air (1972)

To assist in evaluation of the physiological aspects of exposure to detergent enzymes and the adequacy of industrial hygiene controls, a method for determining air concentrations of proteolytic enzymes was developed. Samples are taken by means of a high-volume sampling technique in which the dust is collected on glass fiber pads. The total dust level is determined gravimetrically; the amount of proteolytic enzyme is determined colorimetrically with dimethylated casein as the substrate and trinitrobenzene sulfonic acid sis the color reagent. Data describing analytical accuracy, precision, and detection limits are presented. Results over a 16-month period for key operating areas indicate a reduction in total dust and enzyme levels as well as a satisfactory position in terms of the TLV. An automated data handling system which serves individual plant and corporate needs is described.
Metabolic flux analysis of hybridoma continuous culture steady state multiplicity (1999)

Physiological state multiplicity was observed in continuous cultures of the hybridoma cell line ATCC CRL-1606 cultivated in glutamine-limited steady state chemostats. At the same dilution rate (0.04 h-1), two physiologically different cultures were obtained which exhibited similar growth rates and viabilities but drastically different cell concentrations (7.36 x 10(5) and 1.36 x 10(6) cells/mL). Metabolic flux analysis conducted using metabolite and gas exchange rate measurements revealed a more efficient culture for the steady state with the higher cell concentration, as measured by the fraction of pyruvate carbon flux shuttled into the TCA cycle for energy generation. The low-efficiency steady state was achieved after innoculation by growing the cells in a nutrient rich environment, first in batch mode followed by a stepwise increase of the dilution rate to its set point at 0.04 h-1. The high-efficiency steady state was achieved by reducing the dilution rate to progressively lower values to 0.01 h-1 resulting in conditions of stricter nutrient limitation. The high energetic efficiency attained under such conditions was preserved upon increasing the chemostat dilution rate back to 0.04 h-1 with a higher nutrient consumption, resulting in approximate doubling of the steady state cell concentration. This metabolic adaptation is unlikely due to favorable genetic mutations and could be implemented for improving cell culture performance by inducing cellular metabolic shifts to more efficient flux distribution patterns.
The script processing technique in modeling/simulation and its role in the generation of animated computer graphics (1986)

The script processing method provides the modeler with an extremely powerful technique for developing simulations of force-on-force engagements that are detailed and/or complex in nature. Through the use of the script processing technique, it is possible to simulate the actions and reactions of opposing forces (logically) in parallel on a computer with a single CPU. The cornerstone of this technique is the input script and associated processing software. Many different scenarios and tactics can be played easily due to the flexibility of the script concept. Just as a script directs players within a framework of scenes and activities for a screenplay, the simulation script directs elements in particular actions such as movement, weapon firing, et cetera. It also provides for contingencies based on the recognition of script-defined situations.
Retention of calcium oxalate crystals in renal tubules. (1991)

Crystal retention within the renal tubules is essential for nephrolithiasis and the development of urinary stone disease. We studied the mechanisms involved in this process by inducing calcium oxalate crystal deposition within the rat renal tubules and examining them using various microscopic techniques. Crystals appeared to be retained either by attachment to the tubular epithelium or by aggregating with other crystals thus becoming large enough to be retained by their collective size.
A Bus Authentication and Anti-Probing Architecture Extending Hardware Trusted Computing Base Off CPU Chips and Beyond (2020)

Tamper-proof hardware designs present a great challenge to computer architects. Most existing research limits hardware trusted computing base (TCB) to a CPU chip and anything off the CPU chip is vulnerable to probing and tampering. This paper introduces a new hardware design that provides strong defenses against physical attacks on interconnecting buses between chips in a computer system thereby extending the hardware TCB beyond CPU chips. The new approach is referred to as DIVOT: Detecting Impedance Variations Of Transmission-lines (Tx-lines). Every Tx-line in a computer system, such as a bus and interconnection wire has a unique, intrinsic, and fingerprint-like property: Impedance Inhomogeneity Pattern (IIP), i.e. the impedance distribution over distance. Such unpredictable, uncontrollable, and non-reproducible IIP fingerprints can be used to authenticate a Tx-line to ensure the confidentiality and integrity of data being transmitted. In addition, physical probes perturb the electromagnetic (EM) field around a Tx-line, leading to an altered IIP. As a result, runtime monitoring of IIPs can also be used to actively detect physical probing, snooping, and wire-tapping on buses. While the physics behind the IIP is known, the major technical breakthrough of DIVOT is the new integrated time domain reflectometer, iTDR, that is capable of carrying out in-situ and runtime monitoring of a Tx-line without interfering with normal data transfers. The iTDR is based on two innovations: analog-to-probability conversion (APC) and probability density modulation (PDM). The iTDR performs runtime IIP measurements noninvasively and is CMOS-compatible allowing it to be integrated with any interface logic connected to a bus. DIVOT is a generic, scalable, cost-effective, and low-overhead security solution for any computer system from servers to embedded computers in smart mobile devices and IoTs. To demonstrate the proposed architecture, a working prototype of DIVOT has been built on an FPGA as a proof of concept. Experimental results clearly showed the feasibility and performance of DIVOT for both hardware authentication and tamperproof applications. More specifically, the probability of correctly identifying a bus is close to 1 with an equal error rate (EER) of less than 0.06% at room temperature. We present an example design that incorporates DIVOT into an off-chip memory bus to protect against physical attacks including probing/snooping, tampering, and cold boot attacks.
A preliminary model of time-pressure dispensing system for bioprinting based on printing and material parameters (2014)

In recent years, computer-assisted technology has been adopted into the field of tissue engineering. The ability to control the input of cell/material using computer technology has spun an active field termed bioprinting. Of the three different types of bioprinting techniques, extrusion-based bioprinting allows deposition of material with varying viscosity range. Several studies optimise the bioprinting process to study the effect of extrusion printing and material parameters in relation to formation quality and cell viability. This article aims to develop a model for a time-pressure extrusion-based biodispensing system, providing a platform for future correlation studies.
Synthesis of Potential Anticancer Agents. XXVI. The Alkylation of 6-Chloropurine<sup>2</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Potential Anticancer Agents. XXVI. The Alkylation of 6-Chloropurine2John A. Montgomery and Carroll Temple Jr.Cite this: J. Am. Chem. Soc. 1961, 83, 3, 630–635Publication Date (Print):February 1, 1961Publication History Published online1 May 2002Published inissue 1 February 1961https://doi.org/10.1021/ja01464a031RIGHTS & PERMISSIONSArticle Views374Altmetric-Citations113LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (738 KB) Get e-Alertsclose Get e-Alerts
Optimizing rule placement in software-defined networks for energy-aware routing (2014)

Software-defined Networks (SDN), in particular OpenFlow, is a new networking paradigm enabling innovation through network programmability. Over past few years, many applications have been built using SDN such as server load balancing, virtual-machine migration, traffic engineering and access control. In this paper, we focus on using SDN for energy-aware routing (EAR). Since traffic load has a small influence on power consumption of routers, EAR allows to put unused links into sleep mode to save energy. SDN can collect traffic matrix and then computes routing solutions satisfying QoS while being minimal in energy consumption. However, prior works on EAR have assumed that the table of OpenFlow switch can hold an infinite number of rules. In practice, this assumption does not hold since the flow table is implemented with Ternary Content Addressable Memory (TCAM) which is expensive and power-hungry. In this paper, we propose an optimization method to minimize energy consumption for a backbone network while respecting capacity constraints on links and rule space constraints on routers. In details, we present an exact formulation using Integer Linear Program (ILP) and introduce efficient greedy heuristic algorithm. Based on simulations, we show that using this smart rule space allocation, it is possible to save almost as much power consumption as the classical EAR approach.
REVIEW OF EQUATIONS OF CONSERVATION IN CURVILINEAR COORDINATES (1992)

Momentum equations are analyzed and reviewed that are expressed in the boundary-fitted curvilinear coordinate systems used in the multidimensional modeling oof estuaries and lakes. The study focuses on nonlinear advection terms. The momentum equations are derived with components specified in contravariant directions. Mathematical coefficients are defined with new physical meanings and comparisons made among equations having different forms for the advection terms. It is shown that conservative forms of the advection terms cannot exist when momentum is expressed in contravariant directions in a curvilinear, orthogonal or nonorthogonal grid system.
Saliency Detection on Light Field (2017)

Saliency detection has recently received increasing research interest on using high-dimensional datasets beyond two-dimensional images. Despite the many available capturing devices and algorithms, there still exists a wide spectrum of challenges that need to be addressed to achieve accurate saliency detection. Inspired by the success of the light-field technique, in this article, we propose a new computational scheme to detect salient regions by integrating multiple visual cues from light-field images. First, saliency prior maps are generated from several light-field features based on superpixel-level intra-cue distinctiveness, such as color, depth, and flow inherited from different focal planes and multiple viewpoints. Then, we introduce the location prior to enhance the saliency maps. These maps will finally be merged into a single map using a random-search-based weighting strategy. Besides, we refine the object details by employing a two-stage saliency refinement to obtain the final saliency map. In addition, we present a more challenging benchmark dataset for light-field saliency analysis, named HFUT-Lytro , which consists of 255 light fields with a range from 53 to 64 images generated from each light-field image, therein spanning multiple occurrences of saliency detection challenges such as occlusions, cluttered background, and appearance changes. Experimental results show that our approach can achieve 0.6--6.7% relative improvements over state-of-the-art methods in terms of the F-measure and Precision metrics, which demonstrates the effectiveness of the proposed approach.
IgE Sensitization to the Nonspecific Lipid-Transfer Protein Ara h 9 and Peanut-Associated Bronchospasm (2013)

Allergen component analysis is now available in many laboratories. The aim of this study was to examine the possible association between peanut allergen IgE components and severity of clinical reactions in patients with a history of peanut allergy. Data and sera collected from 192 patients within the Manchester Allergy Research Database and Serum Bank were used in this retrospective study. Sensitization to peanut specific IgE and Ara h 1, 2, 3, and 8 peanut IgE components, as measured by fluoroenzyme immunoassay, was not associated with anaphylaxis. In contrast, sensitization to the lipid-transfer protein Ara h 9 was significantly more prevalent in patients with peanut-associated bronchospasm (26% versus 9% of patients), even after adjusting for potential confounding effects of age, gender, and severity of concomitant chronic atopic diseases. Patients who were sensitized to Ara h 9 were more likely to have ingested rather than just have had skin contact with peanut and have a more rapid onset of symptoms. These results are consistent with observations that sensitization to heat and protease resistant lipid-transfer protein components of hazelnut, grains, and fruit is predictive of anaphylaxis.
Geospatial Object Detection in Remote Sensing Imagery Based on Multiscale Single-Shot Detector with Activated Semantics (2018)

Geospatial object detection from high spatial resolution (HSR) remote sensing imagery is a heated and challenging problem in the field of automatic image interpretation. Despite convolutional neural networks (CNNs) having facilitated the development in this domain, the computation efficiency under real-time application and the accurate positioning on relatively small objects in HSR images are two noticeable obstacles which have largely restricted the performance of detection methods. To tackle the above issues, we first introduce semantic segmentation-aware CNN features to activate the detection feature maps from the lowest level layer. In conjunction with this segmentation branch, another module which consists of several global activation blocks is proposed to enrich the semantic information of feature maps from higher level layers. Then, these two parts are integrated and deployed into the original single shot detection framework. Finally, we use the modified multi-scale feature maps with enriched semantics and multi-task training strategy to achieve end-to-end detection with high efficiency. Extensive experiments and comprehensive evaluations on a publicly available 10-class object detection dataset have demonstrated the superiority of the presented method.
Purpura haemorrhagica in 53 horses (2003)

The medical records of 53 horses with purpura haemorrhagica were reviewed. Seventeen of them had been exposed to or infected with Streptococcus equi, nine had been infected with Corynebacterium pseudotuberculosis, five had been vaccinated with S. equi M protein, five had had a respiratory infection of unknown aetiology, and two had open wounds; the other 15 cases had no history of recent viral or bacterial infection. The horses were between six months and 19 years of age (mean 8.4 years). The predominant clinical signs were well demarcated subcutaneous oedema of all four limbs and haemorrhages on the visible mucous membranes; other signs included depression, anorexia, fever, tachycardia, tachypnoea, reluctance to move, drainage from lymph nodes, exudation of serum from the skin, colic, epistaxis and weight loss. Haematological and biochemical abnormalities commonly detected were anaemia, neutrophilia, hyperproteinaemia, hyperfibrinogenaemia, hyperglobulinaemia and high activities of muscle enzymes. All of the horses were treated with corticosteroids; 42 also received non-steroidal anti-inflammatory drugs and 26 received antimicrobial drugs. Selected cases received special nursing care, including hydrotherapy and bandaging of the limbs. Most of the horses were treated for more than seven days and none of them relapsed. Forty-nine of the horses survived, one died and three were euthanased, either because their severe clinical disease failed to respond to treatment or because they developed secondary complications. Two of the four non-survivors had been vaccinated against S. equi with a product containing the M protein, one had a S. equi infection and the other had a respiratory infection of undetermined aetiology.
Inhibition of hepatitis C virus NS3 protease by peptides derived from complementarity‐determining regions (CDRs) of the monoclonal antibody 8D4: tolerance of a CDR peptide to conformational changes of a target (2002)

We have synthesized and characterized peptides derived from complementarity-determining regions (CDRs) of 8D4, a mouse monoclonal antibody against NS3 protease domain of hepatitis C virus. 8D4 inhibits enzymatic activity without its cofactor, NS4A peptide. One of the synthetic peptides derived from CDRs, CDR1 of the heavy-chain (CDR-H1) peptide strongly inhibited NS3 protease activity competitively in the absence of NS4A and non-competitively in the presence of NS4A. Moreover, cyclic CDR-H1 peptides bridged by disulfide inhibited NS3 protease more potently. The chain length of the CDR-H1 peptide is critical for strong inhibition, even when the peptide is circularized. This finding suggests the importance of peptide conformation. In contrast to a cognate antibody molecule, CDR-derived peptides may provide good ligands for target molecules by having a tolerance to conformational changes of the targets caused by cofactor binding or mutation.
[Cu(dap)<sub>2</sub>Cl] As an Efficient Visible‐Light‐Driven Photoredox Catalyst in Carbon–Carbon Bond‐Forming Reactions (2012)

Copper sees the light of day: [Cu(dap)(2)Cl] proved to be an excellent photoredox catalyst for atom-transfer radical addition reactions, as well as for allylation reactions (see scheme), providing an attractive alternative to commonly used iridium- and ruthenium-based catalysts.
Cage-Shaped Borate Esters with Enhanced Lewis Acidity and Catalytic Activity (2006)

[structure: see text] A cage shape causes high Lewis acidity and catalytic activity on boron. Borate esters that have cage-shaped ligands have accessible LUMO with lower eigenvalues than normal open-shaped borate esters. A large dihedral angle at C-O-B-O in cage-shaped borate esters induces less overlap between p-orbitals on O and B. The hetero-Diels-Alder reaction is effectively catalyzed by the cage-shaped borate, although the open-shaped borate does not act as a catalyst.
<title>Fabrication and reliability testing of Ti/TiN heaters</title> (1999)

We present a new material for highly resistive heaters: thin Ti/TiN layers. Their resistivity is indeed comparable to the resistivity of NiCr, i.e. 50-100 micro-Ohn-cm. However, as opposed to the latter material, Ti/TiN is CMOS compatible and thus easier to incorporate in CMOS integrated MEMS processing. To test the reliability of thin Ti/TiN resistive heaters, both 5 nm Ti/30 nm TiN and 5 nm Ti/60 nm TiN heaters were fabricated. A thermal analysis shows a small temperature coefficient of resistivity. To test the reliability of such heaters at temperatures up to 300 degrees C, 1 micron wide Ti/TiN lines were biased using high currents. Both DC and pulsed DC current stressing resulted in very small deviations from the initial resistance for sintered and passivated heaters. The temperature uniformity over the heater line is investigated using Emission Microscopy.
Liquid-crystal point-diffraction interferometer for wave-front measurements (1996)

A new instrument, the liquid-crystal point-diffraction interferometer (LCPDI), is developed for the measurement of phase objects. This instrument maintains the compact, robust design of Linnik's point-diffraction interferometer and adds to it a phase-stepping capability for quantitative interferogram analysis. The result is a compact, simple to align, environmentally insensitive interferometer capable of accurately measuring optical wave fronts with very high data density and with automated data reduction. We describe the theory and design of the LCPDI. A focus shift was measured with the LCPDI, and the results are compared with theoretical results.
Comparison of direct immunofluorescence and direct immunoperoxidase procedures for detection of herpes simplex virus antigen in lesion specimens (1983)

Direct immunofluorescence and direct immunoperoxidase staining were equally sensitive and specific for detection of herpes simplex virus antigen in lesion specimens, and each method showed 82% agreement with virus isolation results.