gebhart/patrepeval huggingface dataset:
A concurrent operating CDRAM for low cost multi-media (1993)

This paper describes a concurrent operating cache DRAM (CDRAM) for low cost multi-media systems, in which the program and graphic data coexist in the main memory. The concurrent operation of the DRAM and SRAM completely removes the idle cycles. As a result, the average access time is equal to the SRAM access time of 6.5 ns with 0.6 /spl mu/m CMOS process. The flash write and direct read/write are also useful for the multi-media systems.
Ultrathin silicon wafer bonding physics and applications (2001)

Controlling the pn-type behavior of a semiconductor such as silicon by adding an extremely small quantity of an impurity (doping) is a central part of inorganic semiconductor electronics since the 20th century. Recent progress in the doping of organic semiconductors strongly suggests the advent of a new era of doped organic semiconductors. Here, the principles and effects of doping at the level of parts per million (ppm) in organic semiconductor films and single crystals are described, including descriptions of complete pn-control, doping sensitization, ppm doping using an extremely low-speed deposition technique reaching 10<sup>-9</sup> nm s<sup>-1</sup> , and emerging ppm-level doping effects, such as trap filling, majority carriers, homojunction formation, and decreased mobility, as well as ppm-level doping effects in organic single crystals measured by the Hall effect, which shows a doping efficiency of 24%. The Wannier excitonic doping of organic single crystals possessing band conduction and the defect science of organic single crystals related to carrier trapping and scattering are introduced as a new scientific field. The dawn of organic single-crystal electronics is also discussed.
DNA and chromatin structure of the human alpha 1 (I) collagen gene. (1984)

The human alpha 1 (I) collagen gene and 48 kilobase pairs of flanking DNA have been isolated on two overlapping cosmids. The alpha 1 (I) gene is 18 kilobase pairs long and contains a single repetitive element of the Alu family; at least 15 repetitive elements are present in the flanking DNA. Analysis of chromatin structure in nuclei isolated from cultured fibroblasts demonstrated a single chromatin domain greater than 65 kilobase pairs in length that contained 9 DNase I-hypersensitive sites. The pattern of hypersensitive sites was also determined in nuclei derived from placental tissue. Five of the DNase I-hypersensitive sites were observed in both placental and fibroblast chromatin including one site near the 5' end and another near the 3' end of alpha 1 (I). An additional two sites located near the 3' end of the alpha 1 (I) gene in fibroblast chromatin are associated with the tissue-specific use of different polyadenylation sites. Two DNase I-hypersensitive sites found only in fibroblast chromatin and one site found only in placental chromatin were located more than 10 kilobase pairs away from the alpha 1 (I) gene and may be related to tissue-specific expression of other genes in the domain. However, the only abundant placental mRNAs from the 65-kilobase pair domain were those transcribed from the alpha 1 (I) gene. These findings suggest that physical linkage does not play a predominant role in controlling coordinate expression of collagen genes.
Anandamide and diet: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding <i>N</i> -acylethanolamines in piglets (2001)

Endogenous ligands of cannabinoid receptors have been discovered recently and include some N-acylethanolamines (NAEs; e.g., N-arachidonoylethanolamine) and some 2-acylglycerols (e.g., sn-2-arachidonoylglycerol). Previously, we found these compounds to be active biologically when administered per os in large quantities to mice. In the present work, piglets were fed diets with and without 20:4n-6 and 22:6n-3 fatty acid precursors of NAEs, in levels similar to those found in porcine milk, during the first 18 days of life, and corresponding brain NAEs were assessed. In piglets fed diets containing 20:4n-6 and 22:6n-3, there were increases in several biologically active NAEs in brain homogenates-20:4n-6 NAE (4-fold), 20:5n-3 NAE (5-fold), and 22:5n-3 and 22:6n-3 NAE (9- to 10-fold). These results support a mechanism we propose for dietary long-chain polyunsaturated fatty acids influences on brain biochemistry with presumed functional sequelae. This paradigm will enable targeted investigations to determine whether and why specific populations such as infants, elderly, or persons suffering from certain clinical conditions may benefit from dietary long-chain polyunsaturated fatty acids.
Recognition of handwritten cursive Arabic characters (1994)

An automatic off-line character recognition system for handwritten cursive Arabic characters is presented. A robust noise-independent algorithm is developed that yields skeletons that reflect the structural relationships of the character components. The character skeleton is converted to a tree structure suitable for recognition. A set of fuzzy constrained character graph models (FCCGM's), which tolerate large variability in writing, is designed. These models are graphs, with fuzzily labeled arcs used as prototypes for the characters. A set of rules is applied in sequence to match a character tree to an FCCGM. Arabic handwritings of four writers were used in the learning and testing stages. The system proved to be powerful in tolerance to variable writing, speed, and recognition rate.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Dynamic magnetic resonance imaging for grading pelvic organ prolapse according to the international continence society classification: Which line should be used? (2007)

Although dynamic MRI shows excellent inter- and intra-observer reliability, its agreement with clinical examination is poor whatever the line used.
Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans. (1997)

Uncoupling protein-2 and -3 (UCP2 and UCP3) are mitochondrial proteins that show high sequence homology with the brown adipocyte-specific UCP1. UCP1 induces heat production by uncoupling respiration from ATP synthesis. UCP2 is widely expressed in human tissues, whereas UCP3 expression seems restricted to skeletal muscle, an important site of thermogenesis in humans. We have investigated the regulation of UCP2 and UCP3 gene expression in skeletal muscle and adipose tissue from lean and obese humans. UCP2 and -3 mRNA levels were not correlated with body mass index (BMI) in skeletal muscle, but a positive correlation (r = 0.55, P < 0.01, n = 22) was found between UCP2 mRNA level in adipose tissue and BMI. The effect of fasting was investigated in eight lean and six obese subjects maintained on a hypocaloric diet (1,045 kJ/d) for 5 d. Calorie restriction induced a similar 2-2.5-fold increase in UCP2 and -3 mRNA levels in lean and obese subjects. To study the effect of insulin on UCP gene expression, six lean and five obese subjects underwent a 3-h euglycemic hyperinsulinemic clamp. Insulin infusion did not modify UCP2 and -3 mRNA levels. In conclusion, the similar induction of gene expression observed during fasting in lean and obese subjects shows that there is no major alteration of UCP2 and -3 gene regulation in adipose tissue and skeletal muscle of obese subjects. The increase in UCP2 and -3 mRNA levels suggests a role for these proteins in the metabolic adaptation to fasting.
The Metabolic and Performance Effects of Caffeine Compared to Coffee during Endurance Exercise (2013)

There is consistent evidence supporting the ergogenic effects of caffeine for endurance based exercise. However, whether caffeine ingested through coffee has the same effects is still subject to debate. The primary aim of the study was to investigate the performance enhancing effects of caffeine and coffee using a time trial performance test, while also investigating the metabolic effects of caffeine and coffee. In a single-blind, crossover, randomised counter-balanced study design, eight trained male cyclists/triathletes (Mean ± SD: Age 41 ± 7 y, Height 1.80 ± 0.04 m, Weight 78.9 ± 4.1 kg, VO2 max 58 ± 3 ml • kg(-1) • min(-1)) completed 30 min of steady-state (SS) cycling at approximately 55% VO2max followed by a 45 min energy based target time trial (TT). One hour prior to exercise each athlete consumed drinks consisting of caffeine (5 mg CAF/kg BW), instant coffee (5 mg CAF/kg BW), instant decaffeinated coffee or placebo. The set workloads produced similar relative exercise intensities during the SS for all drinks, with no observed difference in carbohydrate or fat oxidation. Performance times during the TT were significantly faster (~5.0%) for both caffeine and coffee when compared to placebo and decaf (38.35 ± 1.53, 38.27 ± 1.80, 40.23 ± 1.98, 40.31 ± 1.22 min respectively, p<0.05). The significantly faster performance times were similar for both caffeine and coffee. Average power for caffeine and coffee during the TT was significantly greater when compared to placebo and decaf (294 ± 21 W, 291 ± 22 W, 277 ± 14 W, 276 ± 23 W respectively, p<0.05). No significant differences were observed between placebo and decaf during the TT. The present study illustrates that both caffeine (5 mg/kg/BW) and coffee (5 mg/kg/BW) consumed 1 h prior to exercise can improve endurance exercise performance.
Molecular Dissection of Zyxin Function Reveals Its Involvement in Cell Motility (1999)

Spatially controlled actin filament assembly is critical for numerous processes, including the vectorial cell migration required for wound healing, cell- mediated immunity, and embryogenesis. One protein implicated in the regulation of actin assembly is zyxin, a protein concentrated at sites where the fast growing ends of actin filaments are enriched. To evaluate the role of zyxin in vivo, we developed a specific peptide inhibitor of zyxin function that blocks its interaction with alpha-actinin and displaces it from its normal subcellular location. Mislocalization of zyxin perturbs cell migration and spreading, and affects the behavior of the cell edge, a structure maintained by assembly of actin at sites proximal to the plasma membrane. These results support a role for zyxin in cell motility, and demonstrate that the correct positioning of zyxin within the cell is critical for its physiological function. Interestingly, the mislocalization of zyxin in the peptide-injected cells is accompanied by disturbances in the distribution of Ena/VASP family members, proteins that have a well-established role in promoting actin assembly. In concert with previous work, our findings suggest that zyxin promotes the spatially restricted assembly of protein complexes necessary for cell motility.
A multilead wavelet-based ECG delineator based on the RMS signal (2006)

In this work a multilead (ML) algorithm for ECG delineation was validated against the CSE and the PTB databases (DB). This algorithm is based on a previously validated single-lead (SL) algorithm, which is also used as reference in this work. For both DB a set of manual reference annotations made by experts is available. The algorithm performance was assessed by the measurement of QRS onset (QRSon) and T wave offset (Toff) in both DB. The differences (mean±sd in ms) between automatic and experts annotations for CSEDB was for QRSon 6.7 ± 7.2 and for Toff 0.1 ± 10.2. For the PTBDB, results were for QRSon −5.7 ± 6.9 and for Toff 11.3 ± 24.4. Also standard deviation of QT interval in 10 consecutive beats was calculated as a measurement of stability in the PTBDB, resulting in 6.7 ± 14.3. In conclusion this ML approach is more recommendable than SL in applications where measurement stability is mandatory and when absolute value of QT is required as a lead-independent measure. 1.
Interleukin 13 and Interleukin 4 Protect Bronchoalveolar Macrophages from Productive Infection with Human Immunodeficiency Virus Type 1 (1994)

In this study, we examined the impact of the predominantly Th2-type lymphokines interleukin 13 (IL-13) and interleukin 4 (IL-4) on acute infection of human bronchoalveolar macrophages with a macrophage-tropic isolate of human immunodeficiency virus type 1 (HIV-1). Addition of 0.01-10 ng of IL-4 or IL-13 per milliliters significantly blocked HIV-1 replication in infected cells, judging from levels of reverse transcriptase and p24 antigen in the supernatants of infected cells. Both IL-4 and IL-13 were almost as efficient as interferon-gamma (IFN-gamma) in preventing HIV-1 replication, when given in equivalent amounts. Moreover, neither IL-13 nor IL-4 interfered with the IFN-gamma-mediated enhancement of anti-HIV-1 activity in alveolar macrophages. Both IL-4 and IL-13 interfered with enhanced replication of HIV-1 in macrophages pulsed with the growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF). Interleukin 13 also prevented HIV-1 release from peripheral blood mononuclear cells in a cocultivation experiment with feeder cells from a seronegative subject. These data suggest that Th2-derived lymphokines have significant anti-HIV-1 activity in cells of the macrophage lineage, although they may enhance the susceptibility of HIV-1-infected subjects to some opportunistic pathogens.
Gal d 6 Is the Second Allergen Characterized from Egg Yolk (2010)

Only one allergen from the egg yolk, alpha-livetin (Gal d 5) has been described thus far. A new egg yolk allergen was detected studying 27 egg allergic patients. The study was performed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and IgE-immunoblotting and IgE-immunoblotting-inhibition assays. An egg yolk extract was fractioned by reverse-phase high-performance liquid chromatography (RP-HPLC), and the new allergen detected was characterized by N-terminal amino acid analysis. A total of 5 of the 27 patients (18%) detected a yolk allergen of an apparent molecular weight of 35 kDa by SDS-PAGE. Heating and reduction treatments did not affect its allergenicity, although digestion with simulated gastric fluid diminished the IgE-binding capacity of the allergen. The N-terminal amino acid sequence corresponded with the YGP42 protein, a fragment of the vitellogenin-1 precursor. Thus, a second egg yolk allergen has been described and designated Gal d 6 by the World Health Organization (WHO)/International Union of Immunological Societies (IUIS) Allergen Nomenclature Subcommittee.
Flow rate maintenance and output of intravenous fluid administration sets (1975)

Seven brands of intravenous fluid administration sets were studied to determine: (1)which set(s) maintained the most consistent flow rates; (2) if the type of fluid container (open, vented or closed, nonvented) affected the flow rates of administration sets; and (3) which set(s) closely approximated the theoretical amounts of fluid to be delivered in one hour at flow rates of 60,100 and 125 ml/hour. Six samples of each brand of administration set were tested in a laboratory setting which approximatedclinical conditions. The type of fluid container had little effect on the performance of the administration sets. The ARDL set was the most accurate in terms of the average volume of fluid delivered in 24 hours. The Burron set required fewer adjustments in 24 hours to maintain a constant flow rate. The U.S. Surgical set recordedthe smallest percent change in flow rate at the end of the first hour. The U.S. Surgical set is rated superior in overall performance. Based on the results of the study,the authors make recommendations to health care personnel, the pharmaceutical industry and the U.S. Pharmacopeial Convention.
Beam current monitoring in the AGS booster and its transfer lines (2002)

The new AGS Booster is designed to accelerate low intensity polarized protons and heavy ions, and high intensity protons. The authors describe the problems and solutions for the beam current monitors in the booster and its transport lines. The wide range of beam parameters and the vacuum, thermal and radiation environment presented challenges in the instrumentation design. While most of the current monitors are external to the vacuum, they must tolerate bakeout at 150 to 300 degrees C, depending on location. The various types of monitors employed are described. Where available, results of the initial operation are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Improving the effectiveness of test suite through mining historical data (2014)

Software regression testing is an integral part of most major software projects. As projects grow larger and the number of tests increases, performing regression testing becomes more costly. If software engineers can identify and run tests that are more likely to detect failures during regression testing, they may be able to better manage their regression testing activities. In this paper, to help identify such test cases, we developed techniques that utilizes various types of information in software repositories. To assess our techniques, we conducted an empirical study using an industrial software product, Microsoft Dynamics AX, which contains real faults. Our results show that the proposed techniques can be effective in identifying test cases that are likely to detect failures.
Apoptosis - the p53 network (2003)

Exposure to cellular stress can trigger the p53 tumor suppressor, a sequence-specific transcription factor, to induce cell growth arrest or apoptosis. The choice between these cellular responses is influenced by many factors, including the type of cell and stress, and the action of p53 co-activators. p53 stimulates a wide network of signals that act through two major apoptotic pathways. The extrinsic, death receptor pathway triggers the activation of a caspase cascade, and the intrinsic, mitochondrial pathway shifts the balance in the Bcl-2 family towards the pro-apoptotic members, promoting the formation of the apoptosome, and consequently caspase-mediated apoptosis. The impact of these two apoptotic pathways may be enhanced when they converge through Bid, which is a p53 target. The majority of these apoptotic effects are mediated through the induction of specific apoptotic target genes. However, p53 can also promote apoptosis by a transcription-independent mechanism under certain conditions. Thus, a multitude of mechanisms are employed by p53 to ensure efficient induction of apoptosis in a stage-, tissue- and stress-signal-specific manner. Manipulation of the apoptotic functions of p53 constitutes an attractive target for cancer therapy.
Comparison of single-mode fiber dispersion measurement techniques (1985)

This paper describes state-of-the-art techniques for characterizing dispersion in single-mode fibers. Special emphasis is placed on achieving high measurement accuracy within the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1.1-1.7 \mu</tex> m wavelength region.
Synthesis of (E)-(2-arylethenyl)silanes by palladium-catalyzed arylation of vinylsilanes in the presence of silver nitrate (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of (E)-(2-arylethenyl)silanes by palladium-catalyzed arylation of vinylsilanes in the presence of silver nitrateKostas Karabelas and Anders HallbergCite this: J. Org. Chem. 1986, 51, 26, 5286–5290Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/jo00376a044https://doi.org/10.1021/jo00376a044research-articleACS PublicationsRequest reuse permissionsArticle Views1553Altmetric-Citations141LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inhibition of HIV-1 Infectivity by Phosphate-Methylated DNA: Retraction (1990)

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Direct liquid introduction/thermospray interface for liquid chromatography/mass spectrometry (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect liquid introduction/thermospray interface for liquid chromatography/mass spectrometryThomas. Covey and Jack. HenionCite this: Anal. Chem. 1983, 55, 14, 2275–2280Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/ac00264a018https://doi.org/10.1021/ac00264a018research-articleACS PublicationsRequest reuse permissionsArticle Views135Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of a whisker sensor system and simulation of active whisking for agent navigation (2005)

The goal of this paper is to explore whisker systems as a sensory modality in animals (rodents) and robots with respect to their adaptive potential. To this end, we have developed an active whisker system. Whiskers from real mice, when attached to capacitor microphones, can detect very weak stimuli at their tips. Different eigen frequencies are induced in the whisker according to the materials over which the whiskers move. Whisking is active, i.e., they can move back and forth to induce sensory stimulation even when an agent is not moving. In this study, active whisking is applied to navigation tasks. The results show that materials can be distinguished using 2-3 kHz signals, which correspond to the experimental evidence obtained from animals.