gebhart/patrepeval huggingface dataset:
Evaluation of Interactive Visualization on Mobile Computing Platforms for Selection of Deep Brain Stimulation Parameters (2012)

In recent years, there has been significant growth in the use of patient-specific models to predict the effects of neuromodulation therapies such as deep brain stimulation (DBS). However, translating these models from a research environment to the everyday clinical workflow has been a challenge, primarily due to the complexity of the models and the expertise required in specialized visualization software. In this paper, we deploy the interactive visualization system ImageVis3D Mobile, which has been designed for mobile computing devices such as the iPhone or iPad, in an evaluation environment to visualize models of Parkinson's disease patients who received DBS therapy. Selection of DBS settings is a significant clinical challenge that requires repeated revisions to achieve optimal therapeutic response, and is often performed without any visual representation of the stimulation system in the patient. We used ImageVis3D Mobile to provide models to movement disorders clinicians and asked them to use the software to determine: 1) which of the four DBS electrode contacts they would select for therapy; and 2) what stimulation settings they would choose. We compared the stimulation protocol chosen from the software versus the stimulation protocol that was chosen via clinical practice (independent of the study). Lastly, we compared the amount of time required to reach these settings using the software versus the time required through standard practice. We found that the stimulation settings chosen using ImageVis3D Mobile were similar to those used in standard of care, but were selected in drastically less time. We show how our visualization system, available directly at the point of care on a device familiar to the clinician, can be used to guide clinical decision making for selection of DBS settings. In our view, the positive impact of the system could also translate to areas other than DBS.
ChemInform Abstract: EFFECT OF FURNACE PREANNEAL AND RAPID THERMAL ANNEALING ON ARSENIC‐IMPLANTED SILICON (1985)

Abstract Die elektrischen Eigenschaften, die Fremdkörper‐Verteilung, Schichtenmobilität und Dotierungsaktivität von bei niedriger Temp. vorgeheizten und dann schnell erhitzten As‐implantierten Si(100)‐Proben werden diskutiert; TEM‐Messungen an Si‐Proben mit und ohne Vorerhitzung (550°C, 1 h) werden miteinander verglichen.
MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response (2012)

Increasing evidence supports the involvement of microRNAs (miRNA) in the regulation of inflammation in human neurological disorders. In the present study we investigated the role of miR-146a, a key regulator of the innate immune response, in the modulation of astrocyte-mediated inflammation. Using Taqman PCR and in situ hybridization, we studied the expression of miR-146a in epilepsy-associated glioneuronal lesions which are characterized by prominent activation of the innate immune response. In addition, cultured human astrocytes were used to study the regulation of miR-146a expression in response to proinflammatory cytokines. qPCR and western blot were used to evaluate the effects of overexpression or knockdown of miR-146a on IL-1β signaling. Downstream signaling in the IL-1β pathway, as well as the expression of IL-6 and COX-2 were evaluated by western blot and ELISA. Release several cytokines was evaluated using a human magnetic multiplex cytokine assay on a Luminex® 100™/200™ platform. Increased expression of miR-146a was observed in glioneuronal lesions by Taqman PCR. MiR-146a expression in human glial cell cultures was strongly induced by IL-1β and blocked by IL-1β receptor antagonist. Modulation of miR-146a expression by transfection of astrocytes with anti-miR146a or mimic, regulated the mRNA expression levels of downstream targets of miR-146a (IRAK-1, IRAK-2 and TRAF-6) and the expression of IRAK-1 protein. In addition, the expression of IL-6 and COX-2 upon IL-1β stimulation was suppressed by increased levels of miR-146a and increased by the reduction of miR-146a. Modulation of miR-146a expression affected also the release of several cytokines such as IL-6 and TNF-α. Our observations indicate that in response to inflammatory cues, miR-146a was induced as a negative-feedback regulator of the astrocyte-mediated inflammatory response. This supports an important role of miR-146a in human neurological disorders associated with chronic inflammation and suggests that this miR may represent a novel target for therapeutic strategies.
Chronic traumatic encephalopathy in a professional American wrestler (2010)

We present in this case report the tissue substrates and forensic evidence for chronic traumatic encephalopathy (CTE) in a professional American wrestler with Apolipoprotein E (apoE) genotyping. Professional wrestling is a contact-sport, with an integral risk for players to sustain repeated concussions over their careers. This case provides the first autopsy evidence of neuropathological abnormalities that accompany CTE in professional American wrestlers. A complete autopsy was performed on a 40-year-old Caucasian male, after he died unexpectedly by suicidal hanging after he had killed his wife and son. The brain showed no atrophy and no recent or remote contusions or necrosis. There was a mild to moderate neocortical neuronal dropout without any amyloid plaques. There were diffuse, sparse to frequent tau-immunoreactive Neurofibrillary Tangles and Neuropil Threads in the neocortex, subcortical ganglia, and brainstem nuclei including the substantia nigra consistent with CTE. The apoE genotype was determined to be E3/E3. Other autopsy findings included cardiomegaly, left ventricular hypertrophy, and bilateral atrioventricular dilatation; toxicologic analyses showed alprazolam and hydrocodone in the blood, and evidence of exogenous testosterone in the urine. Longitudinal studies of professional contact-sport athletes are needed to identify the differentiating characteristics of athletes who develop CTE and devise strategies for intervention.
The relationship of the dimer content of rosin determined by gas chromatography to crystallization time (1965)

Abstract The resin acid dimer content of rosin influences the crystallization time, as determined with the Burrell‐Castor Gelometer. A gas chromatographic packing prepared by treatment of Chromosorb W with dimethyldichlorosilane and trimethylchlorosilane resolved the methyl esters of rosin dimers into 15 components. A vacuum stripping method for assay of rosin dimer agrees with results obtained by quantitative gas chromatography.
Cloning and sequencing of a gene encoding a 21-kilodalton outer membrane protein from Bordetella avium and expression of the gene in Salmonella typhimurium (1992)

Three gene libraries of Bordetella avium 197 DNA were prepared in Escherichia coli LE392 by using the cosmid vectors pCP13 and pYA2329, a derivative of pCP13 specifying spectinomycin resistance. The cosmid libraries were screened with convalescent-phase anti-B. avium turkey sera and polyclonal rabbit antisera against B. avium 197 outer membrane proteins. One E. coli recombinant clone produced a 56-kDa protein which reacted with convalescent-phase serum from a turkey infected with B. avium 197. In addition, five E. coli recombinant clones were identified which produced B. avium outer membrane proteins with molecular masses of 21, 38, 40, 43, and 48 kDa. At least one of these E. coli clones, which encoded the 21-kDa protein, reacted with both convalescent-phase turkey sera and antibody against B. avium 197 outer membrane proteins. The gene for the 21-kDa outer membrane protein was localized by Tn5seq1 mutagenesis, and the nucleotide sequence was determined by dideoxy sequencing. DNA sequence analysis of the 21-kDa protein revealed an open reading frame of 582 bases that resulted in a predicted protein of 194 amino acids. Comparison of the predicted amino acid sequence of the gene encoding the 21-kDa outer membrane protein with protein sequences in the National Biomedical Research Foundation protein sequence data base indicated significant homology to the OmpA proteins of Shigella dysenteriae, Enterobacter aerogenes, E. coli, and Salmonella typhimurium and to Neisseria gonorrhoeae outer membrane protein III, Haemophilus influenzae protein P6, and Pseudomonas aeruginosa porin protein F. The gene (ompA) encoding the B. avium 21-kDa protein hybridized with 4.1-kb DNA fragments from EcoRI-digested, chromosomal DNA of Bordetella pertussis and Bordetella bronchiseptica and with 6.0- and 3.2-kb DNA fragments from EcoRI-digested, chromosomal DNA of B. avium and B. avium-like DNA, respectively. A 6.75-kb DNA fragment encoding the B. avium 21-kDa protein was subcloned into the Asd+ vector pYA292, and the construct was introduced into the avirulent delta cya delta crp delta asd S. typhimurium chi 3987 for oral immunization of birds. The gene encoding the 21-kDa protein was expressed equivalently in B. avium 197, delta asd E. coli chi 6097, and S. typhimurium chi 3987 and was localized primarily in the cytoplasmic membrane and outer membrane. In preliminary studies on oral inoculation of turkey poults with S. typhimurium chi 3987 expressing the gene encoding the B. avium 21-kDa protein, it was determined that a single dose of the recombinant Salmonella vaccine failed to elicit serum antibodies against the 21-kDa protein and challenge with wild-type B. avium 197 resulted in colonization of the trachea and thymus with B. avium 197.
On the<i>in Vitro</i>and<i>in Vivo</i>Activity of a New Synthetic Hexapeptide that Acts on the Pituitary to Specifically Release Growth Hormone* (1984)

His-DTrp-Ala-Trp-DPhe-LysNH2, [His1,Lys6] GHRP, is a new synthetic hexapeptide which specifically elicits a dosage-related release of GH in vitro and in vivo without a concomitant release of LH, FSH, TSH, or PRL and, in limited in vivo studies, insulin or glucagon. Our results indicate that this small peptide has the attributes of a hypophysiotropic hormone. In vitro the minimum and maximum active dosages ranged from 1-10 ng/ml in the pituitary incubate assay. It was active in rats, monkeys, lambs, calves, and under special experimental conditions chicks, indicating its lack of species dependency. It was active when administered iv, sc, or ip to rats. After iv injection, GH levels rose within 2 min, peaked at +10-20 min, and by 2 h usually had returned to normal. It was not possible to directly compare the potencies of [His1,Lys6]GHRP, and the GH-releasing factors GHRF-44 and GHRF-40 after a single sc injection in rats because the time course of the GH response of these peptides was different. The GH response of [His1,Lys6]GHRP was longer in duration than either of these larger peptides. Both SRIF-14 and SRIF-28 inhibited the GH response of the hexapeptide; however, SRIF-28 was about four times more active than SRIF-14 in vitro and 7.5 times more active in vivo. When this small peptide was administered sc once or twice daily to immature rats for 9 or 25 days, the BW gain increased above the control. At the end of the weight gain studies the pituitary remained fully responsive to the peptide. Thus, [His1,Lys6] GHRP may be a valuable peptide for investigating the function of the pituitary somatotrophs and, in addition, it has the potential for increasing BW gain of a variety of normal animals by inducing GH release via a direct pituitary site of action.
Polycrystalline <i>n</i>-SrTiO3 as an electrode for the photoelectrochromic switching of Prussian blue films (1987)

We have developed methods for the preparation of polycrystalline n-SrTiO3 electrodes which show low dark currents and reasonable efficiencies for photoelectrochromic switching of Prussian blue films. Electrochemical methods were used to characterize the polycrystalline electrodes and the Prussian blue films. The Prussian blue→Prussian white charge-transfer reaction occurs via a state within the SrTiO3 band gap, located at ∼−0.68 V (versus saturated calomel electrode), the same as that measured on single-crystal n-SrTiO3 electrodes. Good image contrast and stability are demonstrated with these polycrystalline electrodes.
Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model (2008)

Hepsin is a serine protease that is widely expressed in different tissues and cell types, most prominently in the normal liver and kidney. Overexpression of hepsin has been associated with prostate cancers, ovarian cancers and renal cell carcinomas. The physiological functions of hepsin in normal tissues and tumors are poorly understood. To gain insight into its function in ovarian cancer, we analyzed the expression and subcellular localization of hepsin protein in ovarian cancer cell lines and tumors. We showed that the membrane-associated hepsin protein is present at desmosomal junctions, where it colocalizes with its putative proteolytic substrate hepatocyte growth factor. Consistent with the growing evidence that desmosomal junctions and their constituents play a role in cancer progression, we demonstrated that overexpression of hepsin promotes ovarian tumor growth in a mouse model. The ability of ectopic hepsin to induce tumor growth in mice is abrogated by the mutation of 3 critical residues in the catalytic domain, thus implicating the enzymatic activity of hepsin in promoting tumor progression.
Detecting worms via mining dynamic program execution (2007)

Worm attacks have been major security threats to the Internet. Detecting worms, especially new, unseen worms, is still a challenging problem. In this paper, we propose a new worm detection approach based on mining dynamic program executions. This approach captures dynamic program behavior to provide accurate and efficient detection against both seen and unseen worms. In particular, we execute a large number of real-world worms and benign programs (executables), and trace their system calls. We apply two classifier-learning algorithms (Naive Bayes and Support Vector Machine) to obtain classifiers from a large number of features extracted from the system call traces. The learned classifiers are further used to carry out rapid worm detection with low overhead on the end-host. Our experimental results clearly demonstrate the effectiveness of our approach to detect new worms in terms of a very high detection rate and a low false positive rate.
High Marks for SmartMarks (A New Bookmarks Organizer from Netscape) (1997)

Abstract Smart Marks, a new software tool from Netscape, is marketed as “Web surfing for people with a life.” This reviewer agrees that it is very useful for those of us who have a hard time keeping track of our bookmarks in Netscape Navigator. SmartMarks allows you to organize your bookmarks into folders, allows you to label and assigri key words to both bookmarks and folders, and monitors your bookmarks for changes in content or location. This last feature makes it an especially useful tool for librarians who have taken on all or part of the responsibility for maintaining a library's home page.
Industrialization of New Haven, Conn., as recorded in reservoir sediments (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIndustrialization of New Haven, Conn., as recorded in reservoir sedimentsK. K. Bertine and M. F. MendeckCite this: Environ. Sci. Technol. 1978, 12, 2, 201–207Publication Date (Print):February 1, 1978Publication History Published online1 May 2002Published inissue 1 February 1978https://pubs.acs.org/doi/10.1021/es60138a002https://doi.org/10.1021/es60138a002research-articleACS PublicationsRequest reuse permissionsArticle Views99Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Heterogeneity in Customization of Recommender Systems By Users with Homogenous Preferences (2016)

Recommender systems must find items that match the heterogeneous preferences of its users. Customizable recommenders allow users to directly manipulate the system's algorithm in order to help it match those preferences. However, customizing may demand a certain degree of skill and new users particularly may struggle to effectively customize the system. In user studies of two different systems, I show that there is considerable heterogeneity in the way that new users will try to customize a recommender, even within groups of users with similar underlying preferences. Furthermore, I show that this heterogeneity persists beyond the first few interactions with the recommender. System designs should consider this heterogeneity so that new users can both receive good recommendations in their early interactions as well as learn how to effectively customize the system for their preferences.
Effects of a progestogen on normal human breast epithelial cell apoptosis in vitro and in vivo (2003)

Many investigators have reported cyclic proliferation of normal human breast epithelial cells. A delicate balance between proliferation and apoptosis (programmed cell death) ensures breast homeostasis. Both the follicular and luteal phases of the menstrual cycle are characterized by proliferation, whereas apoptosis occurs only at the end of the latter phase. In this study, we observed that the withdrawal of a synthetic progestin (nomegestrol acetate or NOMAC), but not continuous treatment with it, induced apoptosis of normal human breast epithelial cells in vitro and in women who applied NOMAC gel to their breasts. Furthermore, this apoptotic response was specific to normal breast cells, since withdrawal of NOMAC did not induce apoptosis of tumoral T47D cells in vitro or of fibroadenoma cells in women. These observations open up new perspectives in the prevention of hyperplasia and breast cancer.
Therapeutic treatment with poly(ADP‐ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury (2007)

Our results support the therapeutic application of PARP inhibitors in the treatment of established AP.
Adaptive separation of unknown narrowband and broadband time series (2002)

Motivated by Thomson's (1982, 1994) multiple taper spectral estimation technique, we derive a new, robust procedure for automatically separating time series data into its constituent narrowband and broadband time series components. The new procedure avoids the pitfalls of adaptive notch filters, PCI method, or other similar algorithms, of mistaking and filtering local spectral peaks of the broadband component as narrowband components by decomposing the data vector into local subbands by a bank of matrix filters. Then in a piecewise fashion, the narrowband components are estimated and then filtered from each subband using the principal component inverse (PCI) method. Finally, the filtered components are coherently recombined to obtain the narrowband and broadband time series estimates. Computer simulation results show that the new procedure works well and can have a performance close to the clairvoyant Wiener filter.
Analysis and design of optical waveguide components with metallization (2003)

Planar optical waveguide components with metallization are analyzed with a mode-matching method that takes into account surface plasmons on the metallization, the plasmon character of TM-modes as well as to any significant extend also radiating modes. A waveguide modulator and a triple waveguide polarization splitter serve as examples also for the optimum design of such waveguide components.
Characterization of Dual Leucine Zipper-bearing Kinase, a Mixed Lineage Kinase Present in Synaptic Terminals Whose Phosphorylation State Is Regulated by Membrane Depolarization via Calcineurin (1996)

The biochemistry and regulation of dual leucine zipper bearing kinase (DLK), a member of the mixed lineage kinase or MLK subfamily of protein kinases, was examined in the nervous system. DLK transcript expression in the nervous system was predominantly neuronal. DLK protein was present in synaptic terminals where it was associated with both plasma membrane and cytosol fractions. Within these two fractions, DLK had differing characteristics. Cytosolic DLK existed in both a phosphorylated and dephosphorylated state; DLK associated with plasma membrane existed in the dephosphorylated state only. On nonreducing SDS-polyacrylamide gel electrophoresis, cytosolic DLK migrated at 130 kDa, while membrane associated DLK migrated with an apparent Mr >/= 260,000. Similarly, DLK transiently expressed in COS 7 cells autophosphorylated in vivo and migrated at approximately 260 kDa when separated by nonreducing SDS-polyacrylamide gel electrophoresis. In cotransfection experiments, FLAG-tagged DLK or a FLAG-tagged truncated DLK mutant (F-Delta520) was coimmunoprecipitated with Myc-tagged DLK and formed complexes under nonreducing conditions consistent with the conclusion that DLK formed covalently associated homodimers in overexpressing COS 7 cells. In aggregating neuronal-glial cultures, depolarization of plasma membrane lead to dephosphorylation of DLK. Treatment of aggregates with 5 nM or 200 nM okadaic acid lead to a shift in electrophoretic mobility consistent with phosphorylation of DLK. Treatment with cyclosporin A, a specific inhibitor of the calcium/calmodulin-dependent protein phosphatase 2B (calcineurin), had no effect on DLK phosphorylation under basal conditions. However, cyclosporin A completely inhibited DLK dephosphorylation upon membrane depolarization.
Is nitric oxide and heparin treatment justified in inflammatory bowel disease? An experimental study (1996)

Microcirculatory disturbances of the colon may contribute to the pathogenesis of inflammatory bowel disease. The aim of the study was to investigate the alterations of rectal blood perfusion in experimental colitis with reference to nitric oxide and heparin treatment. The study was carried out on 36 rats, divided into six groups: group I, control; group II, control ± NG-nitro-L-arginine (L-MA); group III, colitis without treatment; group IV, colitis ± L-arginine; group V, colitis ± L-MA; group VI, colitis ± heparin treatment. Experimental colitis was induced by 4% acetic acid enema, and 48 h after the enema, besides the measurement of rectal capillary blood flow by means of laser Doppler flowery, the serum interleukin-6 (IL-6) level and histopathological alterations within the rectal mucks were examined. Experimental colitis resulted in a drop in rectal wall perfusion. L-Arginine and heparin treatment improved the microcirculatory values. The highest IL-6 level and the most advanced histopathological alterations were observed in the rats treated with L-NNA. L-Arginine treatment had no influence on IL-6 concentration, however it aggravated the inflammatory changes within the rectal mucosa. Heparin administration reduced the IL-6 values and also had a positive impact on the microscopic alterations within the rectal wall. It is concluded that heparin treatment has a beneficial effect on the microcirculatory disturbances and inflammatory changes observed in experimental colitis. The inhibition of nitric oxide-synthase aggravated the course of experimental colitis. L-Arginine administration improves the rectal blood flow but aggravates the histopathological alterations within the rectal wall.