gebhart/patrepeval huggingface dataset:
Long Term Improvement in <i>mdx</i> Cardiomyopathy after Therapy with Peptide‐conjugated Morpholino Oligomers (2009)

The cardiomyopathy found in Duchenne Muscular Dystrophy (DMD) is responsible for death due to heart failure in ~30% of patients. Strategies to bypass DMD‐causing mutations to allow an increase in body‐wide dystrophin have proven promising, but increasing cardiac dystrophin continues to be challenging. The purpose of this study was to determine if therapeutic restoration of cardiac dystrophin improved the significant cardiac hypertrophy and diastolic dysfunction identified in mdx dystrophin‐null mice. mdx mice were treated with an arginine‐rich cell‐penetrating peptide‐conjugated phosphorodiamidate morpholino oligomer (PPMO) that delivered a splice‐switching oligonucleotide‐mediated exon skipping therapy to restore dystrophin in mdx mice. PPMO successfully restored cardiac dystrophin expression, preserved cardiac sarcolemma integrity, and significantly reversed the cardiac pathology found in mdx ‐null mice. By echocardiography and Doppler analysis, we identified that PPMO treatment ameliorated the cardiac hypertrophy and diastolic dysfunction identified in mdx mice and provided a durable cardiac improvement for up to 6 months. These results demonstrate for the first time that PPMO‐mediated exon skipping therapy early in the course of DMD may effectively retard the mdx associated cardiac hypertrophy and diastolic dysfunction with significant long‐term impact.
Stress Detection Using Low Cost Heart Rate Sensors (2016)

The automated detection of stress is a central problem for ambient assisted living solutions. The paper presents the concepts and results of two studies targeted at stress detection with a low cost heart rate sensor, a chest belt. In the device validation study ( n = 5), we compared heart rate data and other features from the belt to those measured by a gold standard device to assess the reliability of the sensor. With simple synchronization and data cleaning algorithm, we were able to select highly (>97%) correlated, low average error (2.2%) data segments of considerable length from the chest data for further processing. The protocol for the clinical study ( n = 46) included a relax phase followed by a phase with provoked mental stress, 10 minutes each. We developed a simple method for the detection of the stress using only three time-domain features of the heart rate signal. The method produced accuracy of 74.6%, sensitivity of 75.0%, and specificity of 74.2%, which is impressive compared to the performance of two state-of-the-art methods run on the same data. Since the proposed method uses only time-domain features, it can be efficiently implemented on mobile devices.
Study of Pineapple Peelings Processing into Vinegar by Biotechnology (2009)

This study aimed to reduce post-harvest losses of pineapple local variety egbenana by the transformation of juice into vinegar through biotechnological process. Vinegar was produced through two successive fermentations: alcoholic and acetic fermentations. The alcohol fermentation was carried out at 30 degrees C using yeast. Biomass, pH and Brix were evaluated daily during the fermentation. Acetic fermentation was carried out at 30 degrees C using an acetic bacteria strain isolated from pineapple wine previously exposed to ambient temperature (28 degrees C) for 5 days. Biomass, pH and acid levels were monitored each 2 days. The performance of acetic bacteria isolated was also assessed by studying their glucose and ethanol tolerance. The study allowed the isolation of yeast coded Saccharomyces cerevisiae (LAS01) and an acetic bacteria coded Acetobacter sp. (ASV03) both occurring in the pineapple juice. The monitoring of successive fermentations indicated that the pineapple juice with sugar concentration of 20 Brix, seeded with 10(6) cells of Saccharomyces cerevisiae (LAS01) for alcoholic fermentation for 4 days and afterwards seeded with 10(6) cells of Acetobacter sp. resulted in 4.5 acetic degree vinegar at Brix 5.3% and pH 2.8 for 23 to 25 days. The study of glucose tolerance of the strain of Acetobacter sp. showed that the growth of acetic bacteria was important in a juice with high concentration of sugar. However, the concentration of ethanol did not effect on the acetic bacteria growth. These results enabled on one hand to improve the manufacturing technology of vinegar from fruits and on the other hand to produce a starter of yeast and acetic bacteria strains for this production.
Removal of Silica from Water (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRemoval of Silica from WaterA. S. Behrman and H. GustafsonCite this: Ind. Eng. Chem. 1940, 32, 4, 468–472Publication Date (Print):April 1, 1940Publication History Published online1 May 2002Published inissue 1 April 1940https://pubs.acs.org/doi/10.1021/ie50364a006https://doi.org/10.1021/ie50364a006research-articleACS PublicationsRequest reuse permissionsArticle Views1634Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Influence of the Red Blood CellPreparation Method on the Efficacyof a Leukocyte Reduction Filter (1996)

The performance of a leukocyte reduction bedside filter with different types of RBC concentrates was analyzed. Three types of RBCs were prepared; buffycoat- depleted RBCs suspended in saline-adenine-glucose-mannitol (SAGM)- additive solution (BC-RBCs; n = 20), RBCs suspended in SAGM-additive solution without huffy coat removal (SAGM-RBCs; n = 20), and RBCs drawn in CPDA-1 conservative solution and processed for component preparation by the platelet-rich plasma method (CPDA-RBCs; n = 20). The units were filtered within 8 h of collection. One filter was used for every 2 units. High numbers of residual WBCs were found even in the units filtered first. Filtration of CPDA-RBCs resulted in a higher residual WBC content than SAGM-RBCs or BC-RBCs (p = 0.0032 and p = 0.0002, respectively). The filter performance strikingly decreased when the WBC load per filter exceeded 4x 10^9 or the platelet load was less than 100 x 10^9. We conclude that filter performance varies with the WBC and platelet content of the RBC concentrates. Under the experimental conditions assayed in this study CPDA-RBCs are the least appropriate ones to be used for bedside leukocyte reduction.
Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform (2009)

We report a chemically modified construct of the Sgc8 aptamer, selected against CEM cells, conjugated to an activator platform for stimulated release of molecules at the tumor surface using DNA template assisted functional group transfer reactions (DTGTR).
Guaiane Sesquiterpenoids Isolated from the Fruits of <i>Torilis japonica</i> and Their Cytotoxic Activity (2010)

Abstract Two new guaiane sesquiterpenoids, 11‐(acetyloxy)‐1,8‐dihydroxyguai‐4‐en‐3‐one ( 5 ) and (1 α ,6 β )‐1,6‐dihydroxytorilin ( 6 ), were isolated from the fruits of Torilis japonica (Umbelliferae), along with four known sesquiterpenes, torilin ( 1 ), torilolone ( 2 ), (1 β )‐1‐hydroxytorilin ( 3 ), and (1 α )‐1‐hydroxytorilin ( 4 ). During the phytochemical investigation, daucosterol, friedelin, and epifriedelanol were also isolated from the plant for the first time. The structures of the new sesquiterpenoids 5 and 6 were determined by comprehensive analyses of MS and NMR spectroscopic data. These isolates were evaluated against human breast cancer cells (MCF‐7) and Lewis lung carcinoma (LLC) cells. Compounds 1, 3 , and 4 exhibited cytotoxic activity against the LLC cells with IC 50 values of 31.3, 32.5, and 34.0 μg/ml, respectively. However, no significant cytotoxicity was found against the MCF‐7 cells for any of the compounds tested.
An Effective Thermal Splicing Method to Join Fluoride and Silica Fibers for a High Power Regime (2015)

A repeatable and simple thermal splicing method for low loss splice between fluoride and silica fibers is presented. The minimum splicing loss of 0.58 dB is achieved experimentally with this approach. Meanwhile, the power capacity of this splicing joint is also tested with a high power fiber laser. The maximum input power is up to 15 W, only limited by the available power of the laser source. To the best of our knowledge, this is the first report on thermal splicing between fluoride and silica fibers operating in a high power regime without any complicated ion-assisted deposition process.
An assessment of iloperidone for the treatment of schizophrenia (2000)

Iloperidone (Novartis' Zomariltrade mark) is an atypical antipsychotic agent for the treatment of schizophrenia. Current trends in the treatment of schizophrenia indicate that some atypical antipsychotics are being recommended as first-line therapy. Atypical antipsychotics, in addition to being dopamine (D) receptor antagonists, are all relatively potent serotonin (5-HT) receptor antagonists and are less likely than conventional dopamine antagonists to induce movement disorders. However, all of these agents differ in their receptor profiles and clinical profiles. Iloperidone, a benzisoxazole, is a mixed 5-HT(2A)/D(2)antagonist. Iloperidone was found to be more potent than its analogues when compared with haloperidol in antagonising climbing behaviour in mice. Iloperidone is extensively metabolised and the main circulating metabolite is reduced iloperidone. In patients treated with iloperidone, a low incidence of extrapyramidal symptoms and weight gain has been shown. Data from Phase II trials demonstrated efficacy in patients at doses of 8 mg/day and tolerability was good up to 32 mg/day. Phase III prospective, double-blind, randomised trials with iloperidone are in progress under the ZEUS (Zomariltrade mark Efficacy Utility and Safety) programme involving 3300 patients. Iloperidone, with a balance of activity at the dopaminergic and serotonergic receptors, has obvious advantages over clozapine and olanzapine, both of which have a similar receptor profile as they favour serotonergic over dopamine receptors. Iloperidone is likely to reach the market in 2001 and has favourable prospects in the atypical antipsychotic market for schizophrenia, which is expanding from US$ 1.5 billion in 2000 to US$ 3 billion in 2005.
Tumor-suppressive <i>miR-34a</i> induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells (2007)

Accumulating evidence suggests a role for microRNAs in human carcinogenesis as novel types of tumor suppressors or oncogenes. However, their precise biological role remains largely elusive. In the present study, we aimed to identify microRNA species involved in the regulation of cell proliferation. Using quantitative RT-PCR analysis, we demonstrated that miR-34a was highly up-regulated in a human colon cancer cell line, HCT 116, treated with a DNA-damaging agent, adriamycin. Transient introduction of miR-34a into two human colon cancer cell lines, HCT 116 and RKO, caused complete suppression of cell proliferation and induced senescence-like phenotypes. Moreover, miR-34a also suppressed in vivo growth of HCT 116 and RKO cells in tumors in mice when complexed and administered with atelocollagen for drug delivery. Gene-expression microarray and immunoblot analyses revealed down-regulation of the E2F pathway by miR-34a introduction. Up-regulation of the p53 pathway was also observed. Furthermore, 9 of 25 human colon cancers (36%) showed decreased expression of miR-34a compared with counterpart normal tissues. Our results provide evidence that miR-34a functions as a potent suppressor of cell proliferation through modulation of the E2F signaling pathway. Abrogation of miR-34a function could contribute to aberrant cell proliferation, leading to colon cancer development.
Light Emission from Quantum-Box Structure by Current Injection (1987)

Light emitting from quantum-box structure by current injection was observed for the first time. GaInAsP/InP quantum-box structures were fabricated from one-dimensional quantum-well (quantum-film) structures grown by OMVPE. Holographic lithography, wet etching, and LPE regrowth techniques were employed. Three-dimensional quantum size effect was suggested by the wavelength shift of the light emission.
Birefringence elimination of bismuth germanate crystal in quasi-reciprocal reflective optical voltage sensor (2013)

Bismuth germanate (Bi(4)Ge(3)O(12), BGO) has been widely utilized for the application of Pockels effect-based voltage and electric field sensors, because it possesses no unwanted effects ideally. However, there are multiple birefringences in BGO crystal induced by natural imperfections, temperature-dependent strain, and external pressure (or stress), which influences the demodulation of the Pockels effect induced by the voltage to be measured. For a Pockels effect-based quasi-reciprocal reflective optical voltage sensor, the influences of the multiple birefringences in BGO crystal are investigated and an elimination scheme is also proposed in this paper. The feasibility of the proposed elimination scheme is simulated and experimentally verified.
Aerosol MALDI with a Reflectron Time-of-Flight Mass Spectrometer (1996)

Aerosol matrix-assisted laser desorption/ionization (MALDI) has been combined with a reflectron time-of-flight mass spectrometer for improved mass resolution. A methanol solution of matrix and analyte was sprayed directly into a reflectron time-of-flight mass spectrometer, and the aerosol particles were irradiated and ionized with a frequency-tripled Nd:YAG laser at 355 nm. Mass resolution of over 300 was observed for the peptides bradykinin, angiotensin II, and gramicidin D and for vitamin B(12). This represents a resolution enhancement of approximately 10-fold over that previously reported for aerosol MALDI with a linear time-of-flight instrument.
Palladium-catalyzed direct arylation of simple arenes in synthesis of biaryl molecules (2006)

Significant progress has been made in the direct arylation of simple arenes. A number of catalyst systems have been developed which enable the intramolecular direct arylation of aryl chlorides, bromides and iodides in high yield as well as conditions capable of achieving intermolecular direct arylation with simple arenes. This account describes recent progress by our group and others in the development of these reactions.
Occlusion Robust Face Recognition with Dynamic Similarity Features (2006)

In this paper, we present a new scheme for face recognition. The main idea is to represent the images with the similarity features against the reference set and to provide the relative match for two images. For any image, we first compute the similarities between it and all the reference images, and then we take these similarities as its feature. Based on the similarity features, a linear discriminating classifier is constructed to recognize the querying image. Inspired by research in cognitive psychology, the perceptual distance based dynamic similarity function is proposed to compute the similarity features. The proposed method can be regarded as a generalization of kernel discriminant analysis, and it can well deal with the nonlinear variations, especially occlusion. Extensive experiments are conducted to show its performance and robustness to occlusion
32 TW atmospheric white-light laser (2007)

Ultrahigh power laser pulses delivered by the Alisé beamline (26J, 32TW pulses) have been sent vertically into the atmosphere. The highly nonlinear propagation of the beam in the air gives rise to more than 400 self-guided filaments. This extremely powerful bundle of laser filaments generates a supercontinuum propagating up to the stratosphere, beyond 20km. This constitutes the highest power “atmospheric white-light laser” to date.
A Frequency Meter for Microwave Spectroscopy (1950)

A frequency meter using known absorption lines as microwave frequency standards has been developed. By mixing signals of unknown microwave frequency fx, standard microwave frequency f0, and known radiofrequency signals nfc from a crystal-controlled harmonic generator, it is possible to obtain a set of ``beat'' frequencies fr which can be detected by a calibrated radio receiver. From the relation fr=±m(fx−f0)±nfcit is possible to determine values for the unknown microwave frequency fx. Tests on methanol absorption lines with ammonia lines as microwave frequency standards show that microwave frequencies can be determined to ±0.03 mc/sec. Advantages of this device over other frequency meters are discussed; the accuracy is ultimately limited by the uncertainties in the value of the standard frequency f0.
Feature-level data fusion for bimodal person recognition (1997)

Consistently high person recognition accuracy is difficult to attain using a single recognition modality. This paper assesses the fusion of voice and outer lip-margin features for person identification. Feature fusion is investigated in the form of audio-visual feature vector concatenation, principal component analysis, and linear discriminant analysis. The paper shows that, under mismatched test and training conditions, audio-visual feature fusion is equivalent to an effective increase in the signal-to-noise ratio of the audio signal. Audio-visual feature vector concatenation is shown to be an effective method for feature combination, and linear discriminant analysis is shown to possess the capability of packing discriminating audio-visual information into fewer coefficients than principal component analysis. The paper reveals a high sensitivity of bimodal person identification to a mismatch between LDA or PCA feature-fusion module and speaker model training noise-conditions. Such a mismatch leads to worse identification accuracy than unimodal identification.
FAULT LOCALIZATION AND SELF-HEALING MECHANISMS FOR FCS NETWORKS 1 (2002)

In the dynamic environment of mobile ad-hoc battlefield (FCS) networks, it is important to have an efficient fault management (FM) system capable of performing dynamic and rapid fault localization and providing appropriate self-healing (service survivability) to mission-critical applications in a timely and efficient manner. This paper presents a multi-layer fault localization mechanism using Bayesian techniques for narrowing down the fault/problem on hand. It also proposes appropriate cost-performance-complexity sensitive self-healing/service survivability mechanisms for FCS networks. 1.
Identification of progenitor cells in long-term spleen stromal cultures that produce immature dendritic cells (2000)

Dendritic cells (DC) are produced continuously by a unique, long-term culture (LTC) system in which hemopoiesis is supported by a splenic stromal cell layer in the absence of added growth factors. Flow cytometric analysis reveals the production of two distinct cell subsets. The more predominant large-cell subset resembles highly endocytic DC that are large, granular, and possess membrane extensions. They also express high levels of the DC markers CD11c, CD11b, DEC-205, and CD80 on their cell surface. They do not resemble mature DC because they express low levels of MHC type II and CD86 molecules, as well as c-kit and Fc receptor (FcR). These are known characteristics of immature DC. Small cells are smaller and less granular than large cells, with negative to low expression of CD11c, DEC-205, and CD86. A majority of small cells express varying levels of CD11b and CD80. Subpopulations of small cells express low levels of c-kit, FcR, and MHC type II, and only a 20% subpopulation is weakly endocytic. Upon transfer to an irradiated stromal layer, cells within the small subset proliferate and differentiate to resemble the large cells in size, complexity, membrane extensions, and CD11c and CD86 expression. The two cell subsets produced in LTC are developmentally linked, with the heterogeneous small-cell subset containing progenitors of the larger homogeneous, immature DC subset. LTC represent a valuable model system for studying DC development from hemopoietic progenitors.
The chemistry of electroluminescent organic materials (1998)

Electroluminescence has been a subject of interest for several decades because of its many applications in areas such as telecommunications or information displays. Light-emitting diodes using p-n junctions of inorganic semiconductors have dominated the field in the last twenty years; however, efficient blue emission has only recently been achieved and inorganic semiconductors are difficult to form over large areas, making the process uneconomic. During the last decade, an explosive growth of activity in the area of organic electroluminescence has occurred in both academia and industry, stimulated by the promise of light-emitting plastics for the fabrication of large, flexible, inexpensive and efficient screens to be used in different applications. Thus, a substantial amount of research is presently directed towards color control and improvement of manufacturability and reliability of devices in order to make their commercialization viable. A great deal of work has been carried out by physicists and materials scientists concerned with the preparation of different device structures and with the use of different techniques for device manufacture. However, all this work would not be possible without the continuous efforts of synthetic chemists to prepare materials with enhanced luminescent properties and processabilities. This article provides a review of the main types of organic materials that have been used in the fabrica-tion of light-emitting diodes either as emitting materials or as charge-transport layers. Special attention will be paid to the different synthetic strategies that have been followed in order to tune the color of the emission, to increase stability of materials and to enhance their processabilities.
Huntingtin Modulates Transcription, Occupies Gene Promoters<i>In Vivo</i>, and Binds Directly to DNA in a Polyglutamine-Dependent Manner (2008)

Transcriptional dysregulation is a central pathogenic mechanism in Huntington's disease, a fatal neurodegenerative disorder associated with polyglutamine (polyQ) expansion in the huntingtin (Htt) protein. In this study, we show that mutant Htt alters the normal expression of specific mRNA species at least partly by disrupting the binding activities of many transcription factors which govern the expression of the dysregulated mRNA species. Chromatin immunoprecipitation (ChIP) demonstrates Htt occupation of gene promoters in vivo in a polyQ-dependent manner, and furthermore, ChIP-on-chip and ChIP subcloning reveal that wild-type and mutant Htt exhibit differential genomic distributions. Exon 1 Htt binds DNA directly in the absence of other proteins and alters DNA conformation. PolyQ expansion increases Htt-DNA interactions, with binding to recognition elements of transcription factors whose function is altered in HD. Together, these findings suggest mutant Htt modulates gene expression through abnormal interactions with genomic DNA, altering DNA conformation and transcription factor binding.