gebhart/patrepeval huggingface dataset:
Zika Virus–Induced Antibody Response Enhances Dengue Virus Serotype 2 Replication In Vitro (2016)

Zika virus has emerged in the Americas, where dengue virus is endemic. Among the 4 serotypes of dengue virus, antibody-dependent enhancement is thought to enhance viral replication and disease severity. Reports suggest that anti-dengue virus antibody may enhance Zika virus replication. We investigated whether Zika virus antibodies enhance dengue virus replication, by exposing C57Bl/6 mice to Zika virus. Polyclonal serum was verified for strong Zika virus-neutralizing, dengue virus-subneutralizing capacity. Then we determined the enhancement capabilities of Zika virus-immune serum for dengue virus in vitro. We showed that Zika virus antibodies have the ability to enhance dengue virus infections, which is important, because in many Zika virus-affected areas, dengue virus is expected to remain endemic.
An Acoustic Analysis of Diadochokinesis in Patients with Parkinson's Disease (2013)

The acoustic analysis of diadochokinesis(DDK) has been used to evaluate dysarthria. However, there has not been an automatic method to evaluate dysarthria. The aim of this study was to introduce a new automated program to measure DDK tasks and to apply this to clinical patients with idiopathic Parkinson's disease(IPD). Fourty-seven patients with IPD and a healthy control group of twenty participants were selected with every DDK task recorded three times. Twenty-five acoustic parameters in the program were developed. The relevant parameters were times of DDK, pitch related parameters, intensity parameters which were analyzed by 2-way ANOVA. Significant differences between the groups were found in the times of DDK, pitch related parameters, and intensity parameters. The findings indicated that the pitch of control group was more stable than that of the IPD. Even though the patients with IPD had a higher intensity value, this phenomenon was caused by the weakness of the IPD group who could not control their speech with a breath.
Mobile communication switching system for voice/nonvoice services (2002)

The architecture and service features of a digital mobile communication switching system are presented. New technologies used in this system include advanced voice coding-decoding equipment that allows low-bit rate speech transmission, a speech path monitoring circuit, and a high-quality nonvoice service control scheme.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Manufacturer Usage Description Specification (2019)

This memo specifies a component-based architecture for manufacturer
usage descriptions (MUD). The goal of MUD is to provide a means for
end devices to signal to the network what sort of access and network
functionality they require to properly function. The initial focus is
on access control. Later work can delve into other aspects. This memo
specifies two YANG modules, IPv4 and IPv6 DHCP options, an LLDP TLV, a
URL, an X.509 certificate extension and a means to sign and verify the
descriptions.
<i>CLCA1</i> gene polymorphisms in chronic obstructive pulmonary disease (2004)

hronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, is a major cause of morbidity and mortality in many countries. The most important risk factor for COPD is cigarette smoking, and nearly 90% of COPD patients are smokers. 1 However, only 15% of cigarette smokers develop clinically significant COPD. 2 COPD is known to aggregate in families, In contrast, there are differences in the prevalence of COPD between different ethnic groups. 5 All these results support the notion that genetic factors are involved in the pathogenesis of COPD. Recent segregation analysis has demonstrated that the genetic components determining forced expiratory volume in 1 second (FEV 1 ) consist of multiple genes, each of which has a small influence, rather than a single Mendelian gene. n intensive search has been ongoing to find the genetic factors responsible for COPD development. Until now, more than 20 polymorphisms of candidate genes have been reported to have an association with COPD. They include genes for proteinases, 7 anti-proteinases, 8-10 anti-oxidants, 11 xenobiotic metabolising enzymes, 12 13 and inflammatory mediators. 14 15 For most of these loci, however, there have been contradictory results. Although genetic heterogeneity among different ethnic groups under different environmental conditions could explain this inconsistency, it is still necessary to confirm the associations of the polymorphisms in different populations.
Thermal oxidation of nickel disilicide (1982)

The thermal oxidation characteristics of nickel disilicide on Si substrates have been investigated in the temperature range of 700–900 °C in dry oxygen and wet oxygen. A surface layer of SiO2 grows parabolically in time. The growth rate is independent on the crystalline structure (epitaxial or polycrystalline) and thickness of the NiSi2 layer. We surmise that the oxidation mechanism is dominated by oxygen diffusion through the growing SiO2. Activation energies for the dry and wet oxidation are 1.0±0.1 eV and 1.5±0.1 eV, respectively. NiSi2 layers on SiO2 oxidize with the same rate—resulting with progressively Ni-rich NiSi2. Preliminary measurements of the oxide quality yield dielectric strength of 2.1×106 V cm−1, and a pinhole density of about 100 per cm2. A survey of oxidation data for Si and other refractory metal silicides shows that their oxidation does not draw similar kinetics to that of NiSi2.
ALKYLIERUNGS, UND ARYLIERUNGSREAKTIONEN MIT GEMINALEN DITHIOLATEN (1981)

Abstract Acylacetonitrile 1 reagieren mit Schwefelkohlenstoff in Gegenwart von Natriumhydrid zu den Dinatriumsalzen 2. Behandlung von 2 mit einem Alkylierungsreagens ergibt die offenkettigen oder cyclischen Acyl-cyanketen-S,S-acetale 3, 4, 8 bzw. 10. Arylierung zu 11 gelingt mit 2,4-Dinitrochlorbenzen. Fügt man zu2 nur ein Äquivalent Methyliodid hinzu und säuert das Reaktionsgemisch an, so entstehen die monoalkylierten Verbindungen 7, während β-Hydroxythioanilide 12 durch Umsetzung von 1 mit Phenylisothiocyanat zugänglich sind. Ein Vergleich der δ-Werte zeigt, daß in 7 und 12 der gleiche Typ für die Chelatisierung des Protons der OH-Gruppe vorliegt. Acyl acetonitriles 1 react with carbon disulfide in the presence of sodium hydride to give disodium salts 2. Treatment of 2 with an alkylation reagent yields the open chain or cyclic acyl cyanketene S,S-acetals 3,4,8 and 10, respectively. Arylation to 11 is successful with 2,4-dinitro-chlorobenzene. Adding only one equivalent of methyl iodide to 2 and acidifying the reaction mixture lead to the monoalkylated compounds 7, whereas β-hydroxythioanilides 12 are available by reaction of 1 with phenyl isothiocyanate. A comparison of the δ-values shows that there exists the same type of the proton's chelation of the OH-group in 7 and 12.
Unnatural Amino Acid Substitution as a Probe of the Allosteric Coupling Pathway in a Mycobacterial Cu(I) Sensor (2009)

The Cu(I) sensor Mycobacterium tuberculosis CsoR is a founding member of a new metalloregulatory protein family. Here we show that two "atom" substitutions of the Nepsilon2 face of a Cu(I) coordinating histidine-61 allosterically uncouple Cu(I) and DNA binding, with no effect on Cu(I) binding affinity and coordination structure. A model analogous to the allosteric switch mechanism in Staphylococcus aureus CzrA, a zinc sensor protein with a completely different fold, is proposed.
Characteristics of CDC group 3 and group 5 coryneform bacteria isolated from clinical specimens and assignment to the genus Dermabacter (1994)

Over a 1-year period, 11 isolates (including 5 from blood cultures) of the recently described CDC group 3 and group 5 coryneform bacteria were derived from clinical specimens and compared with reference strains. Biochemical characteristics indicated a very close relationship between CDC group 3 and group 5 coryneform bacteria. The ability of CDC group 3 and the inability of CDC group 5 coryneform bacteria to ferment xylose were the only reactions that were different for the two taxa. Chemotaxonomic features of the two groups included the presence of meso-diaminopimelic acid, a lack of mycolic acids, and the presence of predominantly branched cellular fatty acids, a combination found among gram-positive rods only in Brevibacterium spp., Brachybacterium faecium, and Dermabacter hominis. 16S rRNA gene sequence analysis revealed that CDC group 3 and group 5 coryneform bacteria are members of the genus Dermabacter, which to date has been isolated exclusively from human skin.
Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6–independent mechanism (2002)

The effects of combined exposure to the checkpoint abrogator UCN-01 and pharmacologic MEK1/2 inhibitors were examined in human multiple myeloma (MM) cell lines. Treatment of RPMI8226, NCI-H929, and U266 MM cells with a minimally toxic concentration of UCN-01 (150 nM) for 24 hours resulted in mitogen-activated protein (MAP) kinase activation, an effect that was blocked by coadministration of the MEK1/2 inhibitor PD184352. These events were accompanied by enhanced activation of p34(cdc2) and a marked increase in mitochondrial damage (loss of DeltaPsim; cytochrome c and Smac/DIABLO (direct IAP binding protein with low pI) release), poly(ADP-ribose) polymerase (PARP) cleavage, and apoptosis. PD184352/UCN-01 also dramatically reduced clonogenic survival in each of the MM cell lines. In contrast to As(2)0(3), apoptosis induced by PD184352/UCN-01 was not blocked by the free-radical scavenger N-acetyl-L-cysteine. Whereas exogenous interleukin 6 substantially prevented dexamethasone-induced lethality in MM cells, it was unable to protect them from PD184352/UCN-01-induced apoptosis despite enhancing Akt activation. Insulinlike growth factor 1 (IGF-1) also failed to diminish apoptosis induced by this drug regimen. MM cell lines selected for a high degree of resistance to doxorubicin, melphalan, or dexamethasone, or displaying resistance secondary to fibronectin-mediated adherence, remained fully sensitive to PD184352/UCN-01-induced cell death. Finally, primary CD138(+) MM cells were also susceptible to UCN-01/MEK inhibitor-mediated apoptosis. Together, these findings suggest that simultaneous disruption of cell cycle and MEK/MAP kinase signaling pathways provides a potent stimulus for mitochondrial damage and apoptosis in MM cells, and also indicate that this strategy bypasses the block to cell death conferred by several other well-described resistance mechanisms.
Closed-loop Servoing using Real-time Markerless Arm Tracking (2018)

We present a simple, efficient method of realtime articulated arm pose estimation using stochastic gradient descent to correct unmodeled errors in the robot’s kinematics with point cloud data from commercial depth sensors. We show that our method is robust to error in both the robot’s joint encoders and in the extrinsic calibration of the sensor; and that it is both fast and accurate enough to provide realtime performance for autonomous manipulation tasks. The efficiency of our technique allows us to embed it in a closedloop position servoing strategy; which we extensively use to perform manipulation tasks. Our method is generalizable to any articulated robot, including dexterous humanoids and mobile manipulators with multiple kinematic chains.
A Mouse Model of Post-Arthroplasty Staphylococcus aureus Joint Infection to Evaluate In Vivo the Efficacy of Antimicrobial Implant Coatings (2010)

Taken together, this mouse model may represent an alternative pre-clinical screening tool to evaluate novel in vivo therapeutic strategies before studies in larger animals and in human subjects. Furthermore, the antibiotic-polymer implant coating evaluated in this study was clinically effective, suggesting the potential for this strategy as a therapeutic intervention to combat post-arthroplasty infections.
Low‐dose cytosine arabinoside regimen induced a complete remission with normal karyotypes in a case with hypoplastic acute myeloid leukaemia with No. 8‐trisomy: <i>in vitro</i> and <i>in vivo</i> evidence for normal haematopoietic recovery (1985)

Complete remission was achieved in a case of hypoplastic acute myeloid leukaemia with chromosomal aberration of No. 8-trisomy by giving very low dose of cytosine arabinoside (ara-C), 10 mg (7 X 5 mg/m2)/d, by 24 h continuous intravenous infusion for 20 d. We observed a definite cytoreduction phase in the bone marrow (BM) before normal haematopoiesis resumed. The remission BM showed only normal karyotypes in all metaphases examined. Granulocyte/macrophage colonies and erythroid bursts recovered sufficiently in numbers and cytogenetic study on single colonies and bursts revealed only normal karyotypes. These observations provide evidence that a low dose ara-C regimen can induce remission by cytoreduction which diverts the growth advantage from the leukaemic clone to the normal clones.
A Case of Malignant Pleural Mesothelioma in the Anterior Mediastinum. (1993)

症例は73歳の男性. 前縦隔腫瘍の精査加療目的にて当院に入院. 患者は10年前に他院で縦隔腫瘍摘出術を受けており, 神経鞘腫と診断されている. 今回我々は経皮針生検を施行したが, 組織診断は得られなかった, 画像上前縦隔腫瘍と診断し, 腫瘍の摘出術を施行. 組織診断は悪性胸膜中皮腫であった. 前回の摘出標本の組織を検討したところ, 同じ組織構造であった. 悪性胸膜中皮腫の頻度は比較的少なく, 特に縦隔内発生の場合はまれであり, 本症例では縦隔腫瘍との鑑別が困難であった. また, 本症における10年以上の生存例もまれで, 本症例は本邦報告例として3例目となり, 興味ある症例であると思われた.
Efficacy of Tie2 Receptor Antagonism in Angiosarcoma (2012)

Angiosarcomas are malignant endothelial cell tumors with few effective systemic treatments. Despite a unique endothelial origin, molecular candidates for targeted therapeutic intervention have been elusive. In this study, we explored the tunica internal endothelial cell kinase 2 (Tie2) receptor as a potential therapeutic target in angiosarcoma. Human angiosarcomas from diverse sites were shown to be universally immunoreactive for Tie2. Tie2 and vascular endothelial growth factor receptor (VEGFR) antagonists inhibited SVR and MS1-VEGF angiosarcoma cell survival in vitro. In the high-grade SVR cell line, Tie2 and VEGF antagonists inhibited cell survival synergistically, whereas effects were largely additive in the low-grade MS1-VEGF cell line. Xenograft modeling using these cell lines closely recapitulated the human disease. In vivo, Tie2 and VEGFR inhibition resulted in significant angiosarcoma growth delay. The combination proved more effective than either agent alone. Tie2 inhibition seemed to elicit tumor growth delay through increased tumor cell apoptosis, whereas VEGFR inhibition reduced tumor growth by lowering tumor cell proliferation. These data identify Tie2 antagonism as a potential novel, targeted therapy for angiosarcomas and provide a foundation for further investigation of Tie2 inhibition, alone and in combinations, in the management of this disease.
Clinical outcome of gliosarcoma compared with glioblastoma multiforme: North Central Cancer Treatment Group results (1998)

The data obtained in this study support the conclusion that gliosarcoma shares significant clinical and genetic similarities with GBM and that the same principles should be applied for patient enrollment in research protocols and treatment for these two kinds of tumor.
Neutron production from<sup>7</sup>Li(d,<i>x</i>n) nuclear fusion reactions driven by high-intensity laser–target interactions (2010)

Numerical simulations of neutron production from deuterium–lithium nuclear fusion reactions have been performed. A set of differential cross sections for the 7Li(d,xn) reaction for incident deuteron energies of up to 50 MeV is assembled. The angular distribution of neutrons from a thick lithium target is simulated and benchmarked against experimental data. Two-stage neutron production from laser–target experiments has been studied as a function of laser intensity and energy. During the first stage a well collimated deuteron beam is generated using a high-intensity ultrashort pulse laser. During the second stage it is transported through a lithium target using a 3D Monte-Carlo ion beam–target deposition model. The neutron yield is estimated to be ∼108 neutrons J−1 laser energy. Some 1010 neutrons can be expected from a ∼100 J petawatt-class laser. For incident deuteron energies above 1 MeV the proposed scheme for neutron production from d–Li reactions is superior to that from d–d reactions, producing a collimated beam of neutrons with higher neutron yield.
Optical Properties of a Continuous Helium–Neon Optical Maser (1962)

A continuous optical maser has been operated at five wavelengths in the near infrared. Such a maser oscillator consists of a medium having optical amplification at the wavelength of interest and a Fabry-Perot interferometer as a resonant cavity. The optical amplification is provided by maser action in a discharge through a mixture of helium and neon gas. The Fabry-Perot interferometer is constructed within the gas volume using two very flat, and highly reflecting, parallel, silica plates. The transmission of the Fabry-Perot plates, although small, allows a beam to pass through each end window, with four milliwatts of continuous output power in the strongest transition at 1.153-μ wavelength. Examination of the beam shows that it is almost diffraction limited for its one-centimeter diameter. The spectral line shape at each transition is made up of three or more components each less than a few hundred cycles in width separated by the spacing of orders in the interferometer.
PS 1-4: Prospective Comparison between TE, SSI, and ARFI for Predicting Fibrosis in Subjects with NAFLD (2016)

Aims: To compare the diagnostic performance of transient elastography (TE), supersonic shear-wave imaging (SSI), and acoustic radiation force impulse (ARFI) imaging for staging liver fibrosis and to find clinical factors which affect liver stiffness measurement (LSM) in a prospective NAFLD cohort. Methods: Ninety-four patients with histologically confirmed NAFLD were included in this prospective cohort study. For each patient, liver stiffness was measured using TE, SSI, and ARFI within 1 month of percutaneous liver biopsy. Diagnostic performance for staging liver fibrosis was evaluated using receiver operating characteristic (ROC) analysis. Clinical, laboratory, and anthropometric data using fat-amount CT and bioelectrical impedance analysis were evaluated as covariates influencing LSM by regression analyses. Results: All three LSM methods were well correlated with fibrosis stages (NASH CRN) (r= 0.416~0.532, p 0.05). ARFI tended to be more specific and SSI tended to be more sensitive to differentiate each fibrosis stage with their best diagnostic performances showing the highest Youden’s index. Anthropometric data were correlated with failure or unreliability of LSM, especially for SSI LSM. In regression analysis, anthropometric data might be confounding factors for SSI LSM, while serum liver injury-related markers might be confounding factors for TE and ARFI LSM. Conclusions: Diagnostic performances of individual LSM modalities for staging liver fibrosis in NAFLD patients were not statistically significantly different. TE or ARFI might fit better for suspicion of advanced fibrosis (≥F3) in NAFLD, while TE or SSI could be more advantageous for suspicion of mild fibrosis (F0~F2) in NAFLD. Pre-LSM anthropometric evaluation may help predicting LSM reliability, especially for SSI.
Heteroepitaxy of Ni-Based Alloys on Diamond (2016)

Growth of perfect heteroepitaxial metal layers on diamond can extend applications of diamond in microelectronics and open new areas for its use in devices with unique electrical properties for operations at elevated temperatures and in harsh environments. This work implements the heteroepitaxy of Ni-based alloys on single-crystal diamond and demonstrates a significant improvement of heteroepitaxial quality. The crystal lattices of the Ni–Cu, Ni–Cu–Cr, and Ni–W alloys used for heteroepitaxy have parameters close to those of diamond, a = 3.567 Å. Heteroepitaxy was achieved on all diamond faces; the best results were obtained on the {100} faces. According to X-ray diffraction data, the lattice parameters of the heteroepitaxial films and diamond in the epitaxial plane differ by no more than 0.5%. The heteroepitaxial quality of the films is characterized by values of 0.3–0.4° of the full widths at half-maximum of the X-ray rocking curve. Structural perfection of the NiCu epitaxial layers becomes better when their lattice parameters match with the diamond ones at the growth temperature. Owing to a good epitaxial matching, epitaxial crystallites of the Ni-based alloys demonstrate good wetting of diamond, despite the absence of chemical adsorption and a metal carbide layer.
Realizing high performance multi-radio 802.11n wireless networks (2011)

We explore the design of a high capacity multi-radio wireless network using commercial 802.11n hardware. We first use extensive real-life experiments to evaluate the performance of closely located 802.11n radios. We discover that even when tuned to orthogonal channels, co-located 802.11n radios interfere with each other and achieve significantly less throughput than expected. Our analysis reveals that the throughput degradation is caused by three link-layer effects: (i) triggering of carrier sensing, (ii) out of band collisions and (iii) unintended frequency adaptation. Using physical layer statistics, we observe that these effects are caused by fundamental limitations of co-located radios in achieving signal isolation. We then consider the use of beamforming antennas, shielding and antenna separation distance to achieve better signal isolation and to mitigate these problems. Our work profiles the gains of different physical isolation approaches and provides insights to network designers to realize high-performance wireless networks without requiring synchronization or protocol modifications.
Association of Polyacrylamide Beads to Polyethylene Terephtalate Prostheses (1993)

A method for the coupling of polyacrylamide beads to polyethylene terephthalate (PET) vascular prostheses is described. The reactional procedure used is performed along several steps; acrylic acid grafting on PET textile fibres, in order to introduce reactive carboxylic groups, introduction of terminal primary amine groups onto the beads, and then, attachment method which consists in coupling carboxylic groups of prostheses with amine groups of modified beads. The relative weight increase of the samples before and after the coupling reaction and, microscopic observations of beads distribution onto the prostheses surface demonstrate the binding feasibility of polyacrylamide matrices to PET prostheses. In the near future, authors expect to replace these beads by microcapsules with polyacrylamide wall and containing active compounds to improve the vascular prostheses biocompatibility.