gebhart/patrepeval huggingface dataset:
Pyroelectric properties of bismuth layer-structured ferroelectric ceramics (1991)

Abstract Pyroelectric properties of a bismuth layer-structured ferroelectric (BLSF) family are studied on ordinarily fired (OF) (nonoriented) and grain-oriented ceramics for pyrosensor materials. The pyroelectric figure of merit, Fv and FD , are evaluated from the measured values of the pyroelectric coefficient, p, the dielectric constant, ε = ε33 T/ε0, and the loss tangent, tan δ. Infrared frequency response measurements give the voltage responsivity, R v, and the detectivity, D* , for infrared sensing figure of merits, which are related with the Fv and FD , respectively. The grain orientation effects using the hot-forging (HF) method enhance the pyroelectric properties by two or more times those of nonoriented (OF) ones. The Mn-doped and grain-oriented (HF) (Na1/2 Bi1/2)1-xCaxBi4Ti4O15[NCBT] ceramics with a lower free permittivity, ε33 T/ε0(= ∼130), a higher electromechanical coupling factor, k 33(= 33 ∼ 40%) and a higher anisotropy, k 33/k 31(= 13 ∼ 17) have a comparable value of Fv and D* to that of PbTiO3-based or PbZrO3-based ceramics, in spite of the high Curie temperature, Tc(= 660 ∼ 680°C).
Fountain codes (2004)

Fountain codes are record-breaking sparse-graph codes for channels with erasures, such as the Internet, where files are transmitted in multiple small packets, each of which is either received without error or not received. Standard file-transfer protocols simply chop a file up into K packet-sized pieces, then repeatedly transmit each packet until it is successfully received. A back-channel is required for the transmitter to find out which packets need retransmitting. In contrast, fountain codes make packets that are random functions of the whole file. The transmitter sprays packets at the receiver without any knowledge of which packets are received. Once the receiver has received any N packets, where N is just slightly greater than the original file-size K, he can recover the whole file. The paper reviews random linear fountain codes, LT codes, and raptor codes. The computational costs of the best fountain codes are astonishingly small, scaling linearly with the file size.
Cancer Prevention: Obstacles, Challenges, and the Road Ahead (2015)

Approaches to reduce the global burden of cancer include two major strategies: screening and early detection and active preventive intervention. The latter is the topic of this Commentary and spans a broad range of activities. The genetic heterogeneity and complexity of advanced cancers strongly support the rationale for early interruption of the carcinogenic process and an enhanced focus on prevention as a priority strategy to reduce the burden of cancer; however, the focus of cancer prevention management should be on individuals at high risk and on primary localized disease in which screening and detection should also play a vital role. The timing and dose of (chemo-)preventive intervention also affects response. The intervention may be ineffective if the target population is very high risk or already presenting with preneoplastic lesions with cellular changes that cannot be reversed. The field needs to move beyond general concepts of carcinogenesis to targeted organ site prevention approaches in patients at high risk, as is currently being done for breast and colorectal cancers. Establishing the benefit of new cancer preventive interventions will take years and possibly decades, depending on the outcome being evaluated. We also propose that comparative effectiveness research designs and the value of information obtained from large-scale prevention studies are necessary in order for preventive interventions to become a routine part of cancer management.
The effects of an acute dose of <i>Rhodiola rosea</i> on exercise performance and cognitive function (2009)

Background: The purpose of this study was to determine the effects of an acute oral dose of 3 mg/kg of Rhodiola rosea (R. rosea) on endurance exercise performance, mood, and cognitive function. Methods: A total of 15 recreationally active college women (21.3 ± 0.09 y, 56.1 ± 6.3 kg; mean ± SD) participated in this study. 2–7 d after a familiarization trial subjects ingested in a double blind, random crossover manner, either R. rosea or a carbohydrate placebo 1 h prior to testing. Exercise testing consisted of a 10 minute warm-up, standardized to 80% of the average watts produced during the familiarization trial, followed by a 6 mile simulated indoor time trial on a Velotron electronic bicycle ergometer. Every 5 min during the time trial, subjects rated their level of perceived exertion using a BORG 10 pt scale. A blood sample was taken pre warm-up, 2 minutes post warm-up, and 2 minutes following completion of the time trial, and was analyzed for lactate concentration. Subjects also completed a Profile of Mood States (POMS) questionnaire and a Stroop's color test pre-warm up and following the completion of the time trial. Subjects returned to the lab 2–7 d later to repeat the testing with the other condition. Results: A 3 mg/kg acute does of R. rosea resulted in a shorter time to completion of the 6 mile time trial course (R. rosea 1544.7 ± 155.2 s, Placebo 1569.5 ± 179.4 s; mean ± SD; p = 0.06) as well as a lower average heart rate during the standardized warm up (R. rosea 138.6 ± 13.3 bpm, Placebo 143.7 ± 12.4 bpm; mean ± SD; p = 0.001). There were no significant differences between treatment conditions for rating of perceived exertion during the time trial. Both treatments resulted in a significant increase in the POMS fatigue score following exercise (p = 0.001), as well as a significant improvement following exercise for the Stroop's test of incongruent words (p = 0.001). No other significant differences between treatments were observed. Conclusion: Acute Rhodiola rosea ingestion decreases the heart rate response to sub-maximal exercise, and appears to improve endurance exercise performance.
UNetGAN: A Robust Speech Enhancement Approach in Time Domain for Extremely Low Signal-to-Noise Ratio Condition (2019)

Speech enhancement at extremely low signal-to-noise ratio (SNR) condition is a very challenging problem and rarely investigated in previous works. This paper proposes a robust speech enhancement approach (UNetGAN) based on U-Net and generative adversarial learning to deal with this problem. This approach consists of a generator network and a discriminator network, which operate directly in the time domain. The generator network adopts a U-Net like structure and employs dilated convolution in the bottleneck of it. We evaluate the performance of the UNetGAN at low SNR conditions (up to -20dB) on the public benchmark. The result demonstrates that it significantly improves the speech quality and substantially outperforms the representative deep learning models, including SEGAN, cGAN fo SE, Bidirectional LSTM using phase-sensitive spectrum approximation cost function (PSA-BLSTM) and Wave-U-Net regarding Short-Time Objective Intelligibility (STOI) and Perceptual evaluation of speech quality (PESQ).
Characterization of a R115777-Resistant Human Multiple Myeloma Cell Line with Cross-Resistance to PS-341 (2005)

The farnesyl transferase inhibitor R115777 has been found to have clinical activity in diverse hematopoietic tumors. Clinical efficacy, however, does not correlate with Ras mutation status or inhibition of farnesyl transferase. To further elucidate the mechanisms by which R115777 induces apoptosis and to investigate drug resistance, we have identified and characterized a R115777-resistant human myeloma cell line. 8226/R5 cells were found to be at least 50 times more resistant to R115777 compared with the parent cell line 8226/S. K-Ras remained prenylated in both resistant and sensitive cells after R115777 treatment; however, HDJ-2 farnesylation was inhibited in both lines, implying that farnesyl transferase (the drug target) has not been mutated. Whereas many 8226 lines that acquire drug resistance have elevated expression of P-glycoprotein, we found that P-glycoprotein expression is not increased in the 8226/R5 line and intracellular accumulation of R115777 was not reduced. In fact, 8226/R5 cells were insensitive to a diverse group of antitumor agents including PS-341, and multidrug resistance did not correlate with the expression of heat shock proteins. Comparison of gene expression profiles between resistant and sensitive cells revealed expression changes in several genes involved in myeloma survival and drug resistance. Future experiments will attempt to identify genes that are directly linked to the resistant phenotype. Identification of molecules associated with R115777 and PS-341 resistance is clinically relevant because both compounds are being tested in solid tumors and hematopoietic malignancies.
Sound-resonance hydrogen sensor (2003)

A hydrogen sensor is reported in which a small piezoelectric-sound-resonance-cavity (PSRC) is used as the sensing element. Detection utilizes sound resonance and acoustic property differences between H2 and air as a sensing mechanism. Changes in H2 concentration result in a shift of the sound-resonance state of the PSRC. Preliminary experiments have demonstrated a sensitivity limit of 8 ppm, a fast response time ∼1.5 second, and detection capabilities over a broad concentration range 10−5&lt;n&lt;0.2.
Phthalocyaninoaluminum Compounds (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhthalocyaninoaluminum CompoundsJames E. Owen and Malcolm E. KenneyCite this: Inorg. Chem. 1962, 1, 2, 331–333Publication Date (Print):May 1, 1962Publication History Published online1 May 2002Published inissue 1 May 1962https://pubs.acs.org/doi/10.1021/ic50002a026https://doi.org/10.1021/ic50002a026research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Transesophageal Echocardiography for Quantifying Size of Patent Foramen Ovale in Patients With Cryptogenic Cerebrovascular Events (2002)

We conclude that 2D TEE measurement of a PFO size is more accurate than the traditionally used contrast technique.
Bronchoscopic interventions in the management of chronic obstructive pulmonary disease (2013)

Though the preliminary results are quite encouraging, further trials need to be done before these procedures can be adopted in daily practice.
Plasma‐graft polymerization of a monomer with double bonds onto the surface of carbon fiber and its adhesion to a vinyl ester resin (2003)

Abstract Double bonds reactive with active radical species were introduced onto the surface of carbon yarn by the plasma‐graft polymerization of adipic acid divinyl ester and ethylene glycol dimethacrylate monomers to increase the adhesive strength in the interface between the carbon yarn and a vinyl ester resin. The degree of grafting increased with increasing polymerization time and polymerization temperature. The degree of grafting depended on both the solvent and the monomer species used in the polymerization, and a high degree was obtained with ethylene glycol dimethacrylate as the conjugated monomer and in a mixture of methyl isobutyrate and water. The grafted yarn, whose surface layer contained double bonds, was reacted with a vinyl ester resin containing benzoyl peroxide and N,N ‐dimethylaniline. The pull‐out force of the yarn embedded in the resin increased with increasing degree of grafting. The failure in pulling out the yarn was cohesive. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 2415–2419, 2003
Microbiome Data Distinguish Patients with Clostridium difficile Infection and Non-C. difficile-Associated Diarrhea from Healthy Controls (2014)

Antibiotic usage is the most commonly cited risk factor for hospital-acquired Clostridium difficile infections (CDI). The increased risk is due to disruption of the indigenous microbiome and a subsequent decrease in colonization resistance by the perturbed bacterial community; however, the specific changes in the microbiome that lead to increased risk are poorly understood. We developed statistical models that incorporated microbiome data with clinical and demographic data to better understand why individuals develop CDI. The 16S rRNA genes were sequenced from the feces of 338 individuals, including cases, diarrheal controls, and nondiarrheal controls. We modeled CDI and diarrheal status using multiple clinical variables, including age, antibiotic use, antacid use, and other known risk factors using logit regression. This base model was compared to models that incorporated microbiome data, using diversity metrics, community types, or specific bacterial populations, to identify characteristics of the microbiome associated with CDI susceptibility or resistance. The addition of microbiome data significantly improved our ability to distinguish CDI status when comparing cases or diarrheal controls to nondiarrheal controls. However, only when we assigned samples to community types was it possible to differentiate cases from diarrheal controls. Several bacterial species within the Ruminococcaceae, Lachnospiraceae, Bacteroides, and Porphyromonadaceae were largely absent in cases and highly associated with nondiarrheal controls. The improved discriminatory ability of our microbiome-based models confirms the theory that factors affecting the microbiome influence CDI. IMPORTANCE The gut microbiome, composed of the trillions of bacteria residing in the gastrointestinal tract, is responsible for a number of critical functions within the host. These include digestion, immune system stimulation, and colonization resistance. The microbiome's role in colonization resistance, which is the ability to prevent and limit pathogen colonization and growth, is key for protection against Clostridium difficile infections. However, the bacteria that are important for colonization resistance have not yet been elucidated. Using statistical modeling techniques and different representations of the microbiome, we demonstrated that several community types and the loss of several bacterial populations, including Bacteroides, Lachnospiraceae, and Ruminococcaceae, are associated with CDI. Our results emphasize the importance of considering the microbiome in mediating colonization resistance and may also direct the design of future multispecies probiotic therapies.
Human immunodeficiency virus type 1 NL4-3 replication in four T-cell lines: rate and efficiency of entry, a major determinant of permissiveness (1991)

Single-cycle infections have been used to study the human immunodeficiency virus type 1 (HIV-1) life cycle in CD4+ T-cell lines that differ in their permissiveness for infection. In single-cycle infections of highly permissive C8166 cells, 50% of the infectious units escaped being blocked by a monoclonal antibody against the virus binding site on CD4 (leu3a) within 30 min. In contrast, 50% of the infectious units for three less permissive cell lines (H9, A3.01, and Jurkat) required 4 h to escape the leu3a block. Entry was also more efficient in the highly permissive cells, with NL4-3 stocks having three times more infectious units for C8166 cells than for H9, A3.01, or Jurkat cells. Postentry steps up through reverse transcription required approximately 3.5 h in each of the cell lines. The times lapsing between reverse transcription and the expression of reverse transcripts ranged from 17 to 25 h in the different cell lines. Virus production per cell was also similar in the different cell lines (within 1.5-fold of each other). These results indicate that a major determinant of the permissiveness of growing T cells for HIV-1 is the rate and efficiency of virus entry.
The External Gelation of Thorium Process for Preparation of ThO<sub>2</sub> and (Th,U)O<sub>2</sub> Fuel Kernels (1979)

For refabrication of high-temperature reactor fuel elements, a process for producing dense ThO2 and (Th,U)O2 microspheres has been developed. The process is an external gelation process and takes full advantage of the gelation features of thorium hydroxide for formation of particles. Unlike other external gelation methods, neither viscosity increase by adding other substances (e.g., organic polymers) to the broth nor drop formation in organic liquids is employed. The method uses few process steps and only simple process equipment. A pilot plant has been constructed that operation with one nozzle can produce 1 kg/h of (Th,U)O2 microspheres 500 µm in diameter.
Privacy Preservation Measurement through Diversity and Anonymity using Closeness (2015)

Public survey data that may Increase the exposure of privacy and census information about the particulars is called the Data sensitivity. To maintain the privacy increase the similarity in the data item and introduce redundancy in such a way that information about individual users can not be disclose. This technique also desires the actual information of the data to not change. In this work we propose a unique method by combining two of the most widely used privacy preservation techniques: K-anonymity and l-diversity. The k-anonymity privacy requirement for publishing micro data requires that each equivalence class contains at least k records. Diversity requires that each equivalence class has at least well-represented values for each sensitive attribute. it is neither necessary nor sufficient to prevent attribute disclosure. Motivated by these limitations, we propose a new notion of privacy called k-anonymity,l-diversity, closeness. We ﬁrst present the base model t-closeness, which requires that the distribution of a sensitive attribute in any equivalence class is close to the distribution of the attribute in the overall table (i.e., the distance between the two distributions should be no more than a threshold t). Based on entropy based closeness and distance measure between the class of data we propose a comprehensive technique to change the dataset to preserve the privacy while keeping the original meaning intact.
Development of Receptor Targeted Magnetic Iron Oxide Nanoparticles for Efficient Drug Delivery and Tumor Imaging (2008)

The development of multifunctional nanoparticles that have dual capabilities of tumor imaging and delivering therapeutic agents into tumor cells holds great promises for novel approaches for tumor imaging and therapy. We have engineered urokinase plasminogen activator receptor (uPAR) targeted biodegradable nanoparticles using a size uniform and amphiphilic polymer-coated magnetic iron oxide (IO) nanoparticle conjugated with the amino-terminal fragment (ATF) of urokinase plasminogen activator (uPA), which is a high affinity natural ligand for uPAR. We further developed methods to encapsulate hydrophobic chemotherapeutic drugs into the polymer layer on the IO nanoparticles, making these targeted magnetic resonance imaging (MRI) sensitive nanoparticles drug delivery vehicles. Using a fluorescent drug doxorubicin (Dox) as a model system, we showed that this hydrophobic drug can be efficiently encapsulated into the uPAR-targeted IO nanoparticles. This class of Dox-loaded nanoparticles has a compact size and is stable in pH 7.4 buffer. However, encapsulated Doxcan be released from the nanoparticles at pH 4.0 to 5.0 within 2 hrs. In comparison with the effect of equivalent dosage of free drug or non-targeted IO-Dox nanoparticles, uPAR-targeted IO-Dox nanoparticles deliver higher levels of Dox into breast cancer cells and produce a stronger inhibitory effect on tumor cell growth. Importantly, Dox-loaded IO nanoparticles maintain their <i>T</i>2 MRI contrast effect after being internalized into the tumor cells due to their significant susceptibility effect in the cells, indicating that this drug delivery nanoparticle has the potential to be used as targeted therapeutic imaging probes for monitoring the drug delivery using MRI.
[Phosphorus removal of agriculture wastewater through subsurface constructed wetland]. (2003)

Phosphorus removal in subsurface constructed wetland treating agriculture non-pointed wastewater was studied in pilot-scale. The experimental results showed that the removal rates of TP increased with HRT increasing when the nominal hydraulic retention time was less than 5 days. The pH decreased distinctly when the retention time was too longer in the batch and sequence style, it may bring on a lower removel rate of TP. The amount of TP that can be removed by harvesting were about 15.8% and 9.5% compared to the total quantity of removing in Phragmitas communis and zizania caduciflora constructed system respectively. Temperature impacted on the removel of TP, the removel rate of TP decreased 30% in the winter compared to summuer.
Synergistic interaction of cigarette smoking and alcohol drinking with serum carotenoid concentrations: findings from a middle-aged Japanese population (2009)

Previous studies have indicated low serum carotenoid concentrations among cigarette smokers and/or alcohol drinkers, but little is known about the interaction of smoking and drinking with serum carotenoids. We tested the hypothesis that smoking and drinking reduce serum carotenoid concentrations synergistically. A total of 1073 subjects (357 male and 716 female) who had received health examinations in the town of Mikkabi, Shizuoka Prefecture, Japan, participated in the study. The subjects were divided into six groups according to alcohol intake (non-drinkers, < 1 g/d; light drinkers, > or = 1, < 25 g/d; moderate-to-heavy drinkers, > or = 25 g/d) and smoking status (non-smokers and current smokers). The dietary intakes and serum concentrations of six carotenoids (lycopene, alpha-carotene, beta-carotene, lutein, beta-cryptoxanthin and zeaxanthin) within each group were evaluated cross-sectionally. The dietary intakes of all carotenoids did not differ in the six groups after adjusting for age and sex. The multivariate-adjusted means of the serum carotenoid concentrations in non-drinkers did not differ between non-smokers and current smokers. In contrast, the adjusted means of serum alpha-carotene, beta-carotene and beta-cryptoxanthin were significantly lower than those with increased alcohol intake, and these lower serum carotenoids among alcohol drinkers were more evident in current smokers than in non-smokers. Serum lycopene of moderate-to-heavy drinkers was significantly lower than that of non-drinkers, but it was not influenced by smoking. Neither smoking nor drinking was associated with the serum concentrations of lutein and zeaxanthin. These results suggest that smoking and drinking may reduce the serum alpha-carotene, beta-carotene and beta-cryptoxanthin concentrations in a synergistic manner.