gebhart/patrepeval huggingface dataset:
A Research on the Methods of Forecasting and Controlling for Air Compressor (2010)

The constant pressure controlling progress of air compressor, limited by the production load and the changing of compression material flow, directly influences the condensation and separation, purification and rectification of the air, and the energy consumption of the system, is a representative time-varying system. In this paper, the coupling correlations among many parameters during the constant pressure controlling progress of air compressor are analyzed, the model of controlled autoregressive integrated moving average (CARIMA) is established, the generalized predictive control strategy based on the cascade control was proposed and had been applied successfully to the governing system of air compressor for separating copious cooling air in a factory. The result indicated that this optimized control law can efficiently eliminate the negative influence on constant pressure speed control system of air compressor by the uncertain perturbations and nonlinearity factors, enhancing control precision and dynamic qualities and reducing the system's energy consumption.
Adapter chimeric antigen receptor (AdCAR)-engineered NK-92 cells: an off-the-shelf cellular therapeutic for universal tumor targeting (2020)

Despite the recent success of CAR T cells targeting CD19 and CD22 in hematological malignancies, the production of CAR T cells still requires an extensive manufacturing process. The well-established NK-92 cell line provides a promising alternative to produce CAR-modified effector cells in a GMP-compliant, cost-effective way. NK-92 can be redirected against a variety of surface antigens by our adapter CAR (AdCAR) system utilizing biotinylated antibodies (bAb) as adapter molecules. Selected bAb were capable of inducing significant AdCAR NK-92-mediated lysis of non-Hodgkin lymphoma (NHL) and mantle-cell lymphoma (MCL) cell lines as well as primary MCL and chronic lymphocytic leukemia (CLL) cells. AdCAR specificity was proven using a JeKo-1 CD19/CD20 knockout antigen-loss model. Moreover, through combinations of bAb, AdCAR NK-92 cells are capable of combatting tumor antigen evasion mechanisms. In conclusion, we successfully generated the AdCAR NK-92 cell line which can be manufactured as an "off-the-shelf, on-demand" product allowing universal and tunable tumor targeting.
First experimental demonstration of combined multicast and unicast video streaming over an optical-label switching network (2006)

This paper experimentally demonstrates, for the first time to our knowledge, the combined multicast and unicast video streaming applications over an optical-label switching network, with edge routers connecting the end-to-end multicast server and clients.
Nuclear Tau, a Key Player in Neuronal DNA Protection (2010)

Tau, a neuronal protein involved in neurodegenerative disorders such as Alzheimer disease, which is primarily described as a microtubule-associated protein, has also been observed in the nuclei of neuronal and non-neuronal cells. However, the function of the nuclear form of Tau in neurons has not yet been elucidated. In this work, we demonstrate that acute oxidative stress and mild heat stress (HS) induce the accumulation of dephosphorylated Tau in neuronal nuclei. Using chromatin immunoprecipitation assays, we demonstrate that the capacity of endogenous Tau to interact with neuronal DNA increased following HS. Comet assays performed on both wild-type and Tau-deficient neuronal cultures showed that Tau fully protected neuronal genomic DNA against HS-induced damage. Interestingly, HS-induced DNA damage observed in Tau-deficient cells was completely rescued after the overexpression of human Tau targeted to the nucleus. These results highlight a novel role for nuclear Tau as a key player in early stress response.
Peculiarities of Polyelectrolyte Multilayer Assembly on Patterned Surfaces (2011)

The layer-by-layer assembly of poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate) is studied on templates with imprinted arrays of microwells ranging from 2 to 25 μm and different aspect ratios. The thickness and microstructure of polyelectrolyte multilayers (PEMs) are measured using scanning electron microscopy. At 0.2 M ionic strength, the PEM film evenly coats the template both inside and outside the microwells. If the film is thinner than the critical value of about 400 nm, PEM microstructures collapse upon dissolving the template. Euler's model of critical stress is used to describe the collapse. At 2 M ionic strength, a substantially thinner PEM film is assembled inside the 25 μm wells than outside. If the well diameter is reduced to 7 and 2 μm, a much thicker PEM film is formed inside the microwells. These observations have been attributed to the changing of polyelectrolyte conformation in the solutions.
The morphology of elastin in non-specific and inflammatory abdominal aortic aneurysms. A comparative transmission, scanning and immunoelectronmicroscopy study. (1995)

The maintenance of the mechanical properties of the vessels results from the correct arrangement of smooth muscle cells and extracellular fibrous proteins (elastin and collagen) in their wall. The morphology of extracellular matrix modifications, particularly of elastin, was investigated in inflammatory (IA) and non specific (NSA) abdominal aortic aneurysms by scanning (SEM), transmission (TEM) and immunoelectron microscopy. Both NSAs and IAs were significantly characterized by extensive extracellular matrix remodelling, including different patterns of elastin degradation. Elastic and collagen fibres distribution appeared to be extensively altered in IAs, while it conformed more to a normal pattern in NSAs. With respect to NSAs, the morphology of elastic fibres in IAs was modified to such an extent that their identification by TEM had a rely on immunocytochemical methods and by SEM on back-scattered electron analysis. The observed ultrastructural changes are indicative of the central role of extracellular matrix modifications in the pathogenesis of IAs and NSAs.
A new ESD protection structure for high-speed GaAs RF ICs (2005)

We demonstrate a new electrostatic discharge (ESD) protection structure for high-speed GaAs RF ICs. The structure is composed of small diodes and large transistors using an InGaP heterojunction bipolar transistor (HBT) technology. Its loading effect and its robustness are evaluated experimentally. The impedance of the new structure at OFF state, represented with an equivalent shunt capacitance and an equivalent shunt resistance, are 0.22 pF and 500 /spl Omega/ at 10 GHz. The structure can withstand +2700-V and -2900-V human body model ESD pulses. It can clamp voltage more effectively than the conventional diode-based ESD structure. The new structure can be used to protect 10 Gb/s input/output pins of high-speed RF ICs against ESD.
Adolphe Prins ou la légitime défense sociale (1990)

info:eu-repo/semantics/published
Lack of Psychotomimetic or Impairing Effects on Psychomotor Performance of Acamprosate (1998)

The possible effects on psychomotor performance, concentration, attention, and mood of acamprosate (calciumacetylhomotaurinate) were assessed using a randomized, double-blind, cross-over, placebo-controlled design involving 12 healthy male volunteers. Acamprosate 2 g daily per os or placebo was administered for seven days and separated by washout intervals of at least 21 days. Objective tests evaluated psychomotor functions (simple reaction time measurement, binary choice reaction test, computerized visual searching task, sustained attention test). Mood was assessed using the Beck Depression Inventory and the Beschwerde-Liste to assess subjective physical impairment. Additionally, a visual 3-D illusion paradigm was applied to measure the psychotomimetic effect. A dose of acamprosate of 2 g/day for seven days was free of any significant effects on mood, concentration, attention, psychomotor performance and did not produce any subjective sedation, excitation or psychotomimetic effects.
PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules (2006)

Loss of function of the tumor suppressor gene PTEN is more frequently encountered in high-grade malignant gliomas than in low-grade gliomas. High-grade gliomas are characterized by their extremely invasive behavior, suggesting that PTEN is one of the important regulators of cell motility and that alterations of its coding gene contribute to a much more invasive tumor cell phenotype. In order to clarify a role of PTEN in glioma invasion, we introduced the wild-type PTEN gene into human malignant glioma cell lines and investigated their motile and invasive activity in a brain slice model that presents circumstances analogous to normal brain conditions in vivo. In addition, we analyzed biochemical and molecular changes resulting from the transfer of PTEN in the glioma cells. Infection of recombinant replication-defective adenovirus vector containing the wild-type PTEN cDNA (Ad5CMV-PTEN) significantly inhibited the cell migration and invasion activities of PTEN-mutated glioma cell lines in in vitro migration and chemoinvasion assays. In an organotypic brain slice model, co-culture of glioma spheroids and rat brain slices demonstrated that Ad5CMV-PTEN transfected cells failed to invade surrounding normal brain tissues. Ad5CMV-PTEN transfer into the glioma cell lines lacking the wild-type gene product decreased the levels of matrix metalloproteinase (MMP)-2 mRNA and inhibited the enzymatic activities of MMP-2 and MMP-9. In contrast, mRNA expression of tissue inhibitor of metalloproteinase (TIMP)-2 was upregulated by the PTEN gene transfer. Introduction of PTEN gene in glioma cell lines markedly reduced the levels of Rac-GTP and Cdc42-GTP, activated forms of these small GTP-binding proteins, and decreased the phosphorylation levels of focal adhesion kinase. These results suggest that PTEN inhibits glioma cell invasion in two ways: suppressing proteolysis of the extracellular matrix by MMPs and modulating the migratory activity of glioma cells to a less motile nature by inactivating two Rho-family GTP-binding proteins, Rac and Cdc42.
A data-driven method for input feature selection within neural prosody generation (2002)

The analysis and selection of input features within machine learning techniques is an important problem if a new system has to be established or the system has to be trained for a new task. Within a Text-to-Speech (ITS) application this task has to be handled while adapting a system to a new language or a new speaker.
Single-Molecule Resolution Fluorescent In Situ Hybridization (smFISH) in the Yeast S. cerevisiae (2013)

Regulating gene expression is a major task for all cellular systems. RNA production and degradation plays a critical role in this process and accurately measuring cellular mRNA levels is essential to understanding gene expression regulation. Classical biochemical assays that study gene expression rely on extracting RNAs from large populations of cells, taking them out of their native context and thereby losing spatial information as well as cell-to-cell variability. In this chapter, we describe a fluorescent in situ hybridization (FISH) technique that circumvents this problem by detecting single RNAs in single cells. The technique employs multiple single-stranded short DNA probes fluorescently labeled with organic dyes that hybridize to target RNAs in fixed cells, allowing quantification and localization of RNAs at the single-cell level and at single-molecule resolution. The protocol described here has been optimized for the yeast S. cerevisiae.
Decellularized Tracheal Extracellular Matrix Supports Epithelial Migration, Differentiation, and Function (2014)

Tracheal loss is a source of significant morbidity for affected patients with no acceptable solution. Interest in engineering tracheal transplants has created a demand for small animal models of orthotopic tracheal transplantation. Here, we examine the use of a decellularized graft in a murine model of tracheal replacement. Fresh or decellularized tracheas harvested from age-matched female donor C57BL/6 mice were transplanted into syngeneic recipients. Tracheas were decellularized using repeated washes of water, 3% Triton X-100, and 3 M NaCl under cyclic pressure changes, followed by disinfection with 0.1% peracetic acid/4% ethanol, and terminal sterilization by gamma irradiation. Tracheas were explanted for immunolabeling at 1, 4, and 8 weeks following surgery. Video microscopy and computed tomography were performed to assess function and structure. Decellularized grafts supported complete reepithelialization by 8 weeks and motile cilia were observed. Cartilaginous portions of the trachea were maintained in mice receiving fresh transplants, but repopulation of the cartilage was not seen in mice receiving decellularized transplants. We observed superior postsurgical survival, weight gain, and ciliary function in mice receiving fresh transplants compared with those receiving decellularized transplants. The murine orthotopic tracheal transplant provides an appropriate model to assess the repopulation and functional regeneration of decellularized tracheal grafts.
Differential Effects of Cytotoxic Drugs on Mortal and Immortalized B-Lymphoblastoid Cell Lines from Normal and Werner's Syndrome Patients. (1998)

We studied the effects of nine cytotoxic drugs on three groups of B-lymphoblastoid cell lines transformed by Epstein-Barr virus (EBV): group 1, mortal cell lines from normal individuals; group 2, immortalized cell lines from normal individuals with strong telomerase activity; group 3, mortal cell lines from Werner's syndrome (WS) patients. Aminoglycoside antibiotics and alkylating drugs showed significantly stronger cytotoxic effects on immortalized cell lines than on mortal cell lines or the cell lines before immortalization. In contrast, topoisomerase II inhibitors showed no difference or they tended to be less cytotoxic to immortalized cell lines. Mortal cell lines from normal individuals and WS patients showed no difference in sensitivity against all the drugs examined except for the topoisomerase I inhibitor, camptothecin, which had a stronger cytotoxic effect on WS cell lines than other cell lines. We discuss the mechanisms underlying these cytotoxic effects.
Strong fibre Bragg-gratings written in highly photosensitive Sn-doped fibres without H2-loading using KrF excimer and UV copper vapour lasers (2001)

Sn-doped silica optical fibres are temperature resistant, have high photosensitivity and low loss at 1.55 µm, properties which make them desirable for use in telecom components and sensors. Results of the fabrication of Bragg gratings in Sn-doped fibres using KrF excimer and UV copper vapour lasers will be presented. 1. Introduction Since the first observation in 1978 by Hill and co-workers [l], photosensitivity has launched many new fields in telecom and fibre optic based devices. In the last decade many papers have been published showing enormous progress both in grating writing techniques and fibre fabrication. New materials have been studied to increase the photosensitivity of telecom optical fibres that would otherwise be insufficient for many applications. SnO2-doping was proposed as a convenient co-dopant [2,3,4,5] because of its low-absorption in the third telecom window at 1.55 µm and high photosensitivity when exposed to 248 KrF excimer laser (KEL) radiation. Recently it was demonstrated that the reflectivity of gratings written with frequency-doubled copper vapour laser (CVL) is similar to the reflectivity of the gratings written with the frequency-doubled argon ion laser [6] . Moreover, the CVL can be used to write simultaneous multiple gratings with identical reflectivity [6,7]. In this work we study the photosensitivity of tin-doped fibres with the CVL and compare it to the photosensitivity achieved with the KEL.
Corneal Haze Development After PRK Is Regulated by Volume of Stromal Tissue Removal (1998)

Excimer laser transepithelial photoablation induced significantly less keratocyte loss than manual epithelial debridement; however, photoablation was followed by a more intense inflammatory response and a greater increase in backscattering of light (haze) that was associated with increased keratocyte activation and myofibroblast transformation. Most important, the magnitude of corneal wound repair and the development and duration of corneal haze increased proportionally with increasing stromal photoablation depth (i.e., the volume of stromal tissue removal) but were unrelated to depth of initial keratocyte loss.
Distributed Shared Memory for Roaming Large Volumes (2006)

We present a cluster-based volume rendering system for roaming very large volumes. This system allows to move a gigabyte-sized probe inside a total volume of several tens or hundreds of gigabytes in real-time. While the size of the probe is limited by the total amount of texture memory on the cluster, the size of the total data set has no theoretical limit. The cluster is used as a distributed graphics processing unit that both aggregates graphics power and graphics memory. A hardware-accelerated volume renderer runs in parallel on the cluster nodes and the final image compositing is implemented using a pipelined sort-last rendering algorithm. Meanwhile, volume bricking and volume paging allow efficient data caching. On each rendering node, a distributed hierarchical cache system implements a global software-based distributed shared memory on the cluster. In case of a cache miss, this system first checks page residency on the other cluster nodes instead of directly accessing local disks. Using two Gigabit Ethernet network interfaces per node, we accelerate data fetching by a factor of 4 compared to directly accessing local disks. The system also implements asynchronous disk access and texture loading, which makes it possible to overlap data loading, volume slicing and rendering for optimal volume roaming.
Ear Temperature Measurements in Healthy Children Using the Arterial Heat Balance Method (2001)

This study was undertaken to determine the upper limit of normal ear temperatures, defined as the 95th percentile for infants, children, and adolescents, using the arterial heat balance method for measuring ear temperatures. Ear temperatures were measured in 62 infants, 0-2 months of age; 346 children, 3-47 months; 226 children, 48-119 months; and 172 adolescents, 120-227 months using the LighTouch Pedi-Q (Exergen Corp, Watertown, MA) ear thermometer. The 95th percentiles for the four age groups were 100.1 degrees F (37.8 degrees C), 100.3 degrees F (37.9 degrees C), 99.8 degrees F (37.7 degrees C), and 99.8 degrees F (37.7 degrees C), respectively. Temperatures above 100.0 degrees F (37.8 degrees C) using the LighTouch Pedi-Q ear thermometer should be considered elevated.
Proposal of Electro-Optical Switching and Memory Devices Utilizing Doping and Undoping Processes of Conducting Polymers (1983)

New optical switching and memory elements utilizing the spectral change of conducting polymers by electro-chemical doping and undoping are proposed.
A computational pathway for bracketing native-like structures for small alpha helical globular proteins (2005)

Impressive advances in the applications of bioinformatics for protein structure prediction coupled with growing structural databases on one hand and the insurmountable time-scale problem with ab initio computational methods on the other continue to raise doubts whether a computational solution to the protein folding problem--categorized as an NP-hard problem--is within reach in the near future. Combining some specially designed biophysical filters and vector algebra tools with ab initio methods, we present here a promising computational pathway for bracketing native-like structures of small alpha helical globular proteins departing from secondary structural information. The automated protocol is initiated by generating multiple structures around the loops between secondary structural elements. A set of knowledge-based biophysical filters namely persistence length and radius of gyration, developed and calibrated on approximately 1000 globular proteins, is introduced to screen the trial structures to filter out improbable candidates for the native and reduce the size of the library of probable structures. The ensemble so generated encompasses a few structures with native-like topology. Monte Carlo optimizations of the loop dihedrals are then carried out to remove steric clashes. The resultant structures are energy minimized and ranked according to a scoring function tested previously on a series of decoy sets vis-a-vis their corresponding natives. We find that the 100 lowest energy structures culled from the ensemble of energy optimized trial structures comprise at least a few to within 3-5 angstroms of the native. Thus the formidable "needle in a haystack" problem is narrowed down to finding an optimal solution amongst a computationally tractable number of alternatives. Encouraging results obtained on twelve small alpha helical globular proteins with the above outlined pathway are presented and discussed.
Muscle Hypertrophy in Rats Fed on a Buckwheat Protein Extract (1999)

Growing rats were examined for the influence of a buckwheat protein diet on muscle weight and protein. In experiment 1, the rats were fed on a diet containing either casein or a buckwheat protein extract (BWPE) as the protein source (10%, 20% or 30%) for 5 wk. The relative weights (g per kg of body wt) of the gastrocnemius, plantaris and soleus muscles were higher in the BWPE-fed animals than in the casein-fed ones, but were unaffected by the dietary level of protein. These differences were not associated with growth. In experiment 2, the rats were fed on either a casein or BWPE diet at the 20% protein level for 5 wk. BWPE intake significantly elevated the gastrocnemius muscle weight, carcass protein and water, and reduced carcass fat. These results demonstrate that BWPE consumption causes muscle hypertrophy, elevates carcass protein and water, and reduces body fat.
Effect of recycling blast furnace flue dust as pellets on the sintering performance (2010)

The Egyptian Iron and Steel Company generates a great amount of blast furnace flue dust. The recovery of metals and carbon from this flue dust becomes a very important demand due to the increase of the price of coke breeze and the decrease of the primary source of metals. At the same time, it make the environment more safe by decreasing pollution. Introducing these dust fines in the sintering process proves to be very harmful for different operating parameters. Thus, this study aims at investigating the production of pellets resulting from these fines, using molasses as organic binder and its application in sintering of iron ore. The sintering experiments were performed using flue dust as pellets as a substitute of coke breeze. The results revealed that, sintering properties such as inter strength increases with using the flue dust pellets, while productivity of both the sinter machine and sinter machine at blast furnace yard decreases. Also the vertical velocity of the sinter machine and the weight loss during the reduction of produced the sinter by hydrogen decrease.