gebhart/patrepeval huggingface dataset:
Metalloselective anti-porphyrin monoclonal antibodies (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetalloselective anti-porphyrin monoclonal antibodiesAlan W. Schwabacher, Michael I. Weinhouse, Maria Teresa M. Auditor, and Richard A. LernerCite this: J. Am. Chem. Soc. 1989, 111, 6, 2344–2346Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/ja00188a082https://doi.org/10.1021/ja00188a082research-articleACS PublicationsRequest reuse permissionsArticle Views187Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermography of the bovine scrotum. (1985)

Thermographic patterns of the bovine scrotum were established in 15 clinically normal bulls and were compared with patterns in 10 bulls with scrotal and testicular diseases. Thermography of a normal scrotum was characterized by a symmetrical and constant thermal pattern with a temperature gradient of 4 degrees to 6 degrees (C) from the base to the apex of the scrotum. There was a significant difference (P less than 0.05) in the temperature from the base to the apex of the scrotum (34.94 +/- 0.60 C to 30.11 +/- 0.91 C). Lack of thermal symmetry was seen in bulls with unilateral lesions. Inflammation of one testicle increased ipsilateral scrotal infrared emission temperature 2.5 degrees to 3 degrees (C) above that in the contralateral side. If both testes were inflamed and hyperemic, there was an overall increase in scrotal temperature of at least 3 degrees (C), and a reduction in temperature gradient of 2 to 3 degrees (C) from the base to the apex of the scrotum. Area temperatures in bulls with chronic testicular degeneration with fibrosis were reduced.
The relationship between work stress and mental disorders in men and women: findings from a population-based study (2007)

Policies improving the work environment may have positive effects on workers' mental health status. Imbalance between work and family life may be a stronger risk factor than work stress for mental disorders. Longitudinal studies incorporating important workplace health research models are needed to delineate causal relationships between work characteristics and mental disorders.
Classifying Breast Cancer Subtypes Using Multiple Kernel Learning Based on Omics Data (2019)

It is very significant to explore the intrinsic differences in breast cancer subtypes. These intrinsic differences are closely related to clinical diagnosis and designation of treatment plans. With the accumulation of biological and medicine datasets, there are many different omics data that can be viewed in different aspects. Combining these multiple omics data can improve the accuracy of prediction. Meanwhile; there are also many different databases available for us to download different types of omics data. In this article, we use estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) to define breast cancer subtypes and classify any two breast cancer subtypes using SMO-MKL algorithm. We collected mRNA data, methylation data and copy number variation (CNV) data from TCGA to classify breast cancer subtypes. Multiple Kernel Learning (MKL) is employed to use these omics data distinctly. The result of using three omics data with multiple kernels is better than that of using single omics data with multiple kernels. Furthermore; these significant genes and pathways discovered in the feature selection process are also analyzed. In experiments; the proposed method outperforms other state-of-the-art methods and has abundant biological interpretations.
Towards the Development of Mixed MT<sub>1</sub>‐Agonist/MT<sub>2</sub>‐Antagonist Melatonin Receptor Ligands (2006)

Herein we report attempts to optimize the pharmacological properties of 5-(2-hydroxyethoxy)-N-acetyltryptamine (5-HEAT), a melatonin receptor ligand previously described by us. Several 5-substituted and 2,5-disubstituted N-acyltryptamines were synthesized and evaluated in vitro for the human cloned MT(1) and MT(2) receptors. From this series of N-acyltryptamines the 2-bromo derivative (5 c) retains the interesting efficacy profile of 5-HEAT and shows increased melatonin receptor affinities; it represents one of the first examples of a high-affinity MT(1) agonist/MT(2) antagonist. Some other full agonists for both melatonin receptors which exhibit similar or increased affinity relative to that of melatonin were obtained.
Integration of reproductive meristem fates by a <i>SEPALLATA</i> -like MADS-box gene (2004)

Reproductive transition, inflorescence architecture, meristem patterning, and floral organ identity have been studied as distinct research areas in plant science. By using the ornamental plant Gerbera, we demonstrate that all of these keystone aspects of reproductive meristematic fate are integrated genetically by a single SEPALLATA-like MADS-box gene from a functional class designated previously as "floral homeotic" or "organ identity." This extended regulatory network has not been elaborated in the model plant systems, which have a floral design and inflorescence-determinacy state that obscures these relationships.
Stress induced leakage current limiting to scale down EEPROM tunnel oxide thickness (2003)

The effects of thinning the FLOTEX EEPROM tunnel oxide on its reliability are investigated using capacitors and cell structures with oxide thickness ranging from 47 to 100 AA. A low-electric-field oxide leakage current is induced by charge injection stressing, and it increases with decreasing oxide thickness. Its conduction mechanism is found to be different from that caused by positive charge accumulation in that it has the opposite thickness dependence. A corresponding increase of charge loss in a write/erase (W/E)-cycled EEPROM cell is observed with decreasing oxide thickness in a room-temperature retention test. When oxide thickness is decreased, the maximum number of W/E cycles to tunnel-oxide breakdown decreases with the decrease in charge to breakdown of the negatively biased gate. For scaling down the EEPROM tunnel oxide, the most serious limiting factor is oxide leakage current induced by W/E cycling stress, resulting in data-retention degradation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Monitoring the conjugal transfer of plasmid RP4 in activated sludge and in situ identification of the transconjugants (1999)

A GFPmut3b-tagged derivative of broad host-range plasmid RP4 was used to monitor the conjugative transfer of the plasmid from a Pseudomonas putida donor strain to indigenous bacteria in activated sludge. Transfer frequencies were determined to be in the range of 4×10−6 to 1×10−5 transconjugants per recipient. In situ hybridisation with fluorescently labeled, rRNA-targeted oligonucleotides was used to phylogenetically affiliate the bacteria that had received the plasmid.
The Transcriptional Repressor Even-skipped Interacts Directly with TATA-Binding Protein (1995)

The Drosophila homeodomain protein Even-skipped (Eve) has previously been shown to function as a sequence-specific transcriptional repressor, and in vitro and in vivo experiments have shown that the protein can actively block basal transcription. However, the mechanism of repression is not known. Here, we present evidence establishing a direct interaction between Eve and the TATA-binding protein (TBP). Using cotransfection assays with minimal basal promoters whose activity can be enhanced by coexpression of TBP, we found that Eve could efficiently block, or squelch, this enhancement. Squelching did not require Eve DNA-binding sites on the reporter plasmids but was dependent on the presence of the Eve repression domain. Further support for an in vivo interaction between the Eve repression domain and TBP was derived from a two-hybrid-type assay with transfected cells. Evidence that Eve and TBP interact directly was provided by in vitro binding assays, which revealed a specific protein-protein interaction that required an intact Eve repression domain and the conserved C terminus of TBP. The Eve homeodomain was also required for these associations, suggesting that it may function in protein-protein interactions. We also show that a previously characterized artificial repression region behaves in a manner similar to that of the Eve repression domain, including its ability to squelch TBP-enhanced expression in vivo and to bind TBP specifically in vitro. Our results suggest a model for transcriptional repression that involves an interaction between Eve and TBP.
Retroviral Transfer of Herpes Simplex Thymidine Kinase Gene into Glioma Cells Causes Targeting of Gancyclovir Cytotoxic Effect (1994)

The thymidine kinase (tk) gene of herpes simplex virus type 1 (HSV-1) was transduced into three glioma cell lines (T98, U251MG, T9) using a retrovirus vector. The supernatants of viral producer cell line PA317/LTRNL was used for infection and three transduced cell lines (T98/LTRNL, U251MG/LTRNL, T9/LTRNL) were established. The toxicities of the anti-herpetic drugs, acyclovir and gancyclovir, were evaluated in vitro. The cytotoxicities of acyclovir and gancyclovir to the HSV-1 tk gene-transduced cells increased 100-1000 fold compared to the non-transduced parental cell lines. The cytotoxic effect of gancyclovir was higher than that of acyclovir, requiring a concentration of less than 0.31 microM to obtain 50% inhibition. Deoxyribonucleic acid analysis of the gancyclovir-treated cells demonstrated fragmentation, suggesting that apoptosis is involved in the mechanism of cell death. The HSV-1 tk gene-transduced cells were co-cultured with parental cells and treated with gancyclovir. More than 95% of cells were killed in a mixture ratio of 1:1, suggesting that the "bystander effect" operated in this system. Selective transduction of HSV-1 tk gene into glioma cells using a retroviral vector and treatment with gancyclovir is a promising therapy for patients with malignant glioma.
Androgen receptor genotypes predict response to endocrine treatment in breast cancer patients (2011)

A marker for a group of patients who responded to TAM, but not to AIs, was identified. If this finding is confirmed, AR genotyping may provide useful information for selection of endocrine treatment of breast cancer patients.
Estrogenic Analogues Synthesized by Click Chemistry (2007)

Fast and simple: the complexity of steroids can be mimicked by two phenol rings linked together by the easiest of reactions: the click [3+2] azide-alkyne cycloaddition. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2007/z600192_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Galactosyl Derivatives of <scp>l</scp>-Arginine and <scp>d</scp>-Arginine:  Synthesis, Stability, Cell Permeation, and Nitric Oxide Production in Pituitary GH<sub>3</sub> Cells (2006)

Nitric oxide (NO) is critical for the normal physiological regulation of the nervous system and other tissues. L-Arginine, but not D-arginine, is the natural substrate for nitric oxide synthase (NOS), for it is enzymatically converted to NO and L-citrulline. However, recent evidence suggests that D-arginine can also produce NO and NO-derivatives via a different pathway. The aim of the present paper was to raise NO levels in the cells by increasing the cell permeation of its precursors. To this aim, two galactosyl prodrugs, L-arginine-D-galactos-6'-yl ester (L-ArgGal) and D-arginine-D-galactos-6'-yl ester (D-ArgGal) were synthesized. Remarkably, using the HPLC-ESI/MS technique, we found that L-ArgGal and D-ArgGal prodrugs both increased the concentration levels of L- and D-arginine and their derivatives in pituitary GH3 cells. Furthermore, we found that D-ArgGal (1) penetrated cell membranes more rapidly than its precursor D-arginine, (2) released arginine more slowly and in greater amounts than L-ArgGal, and (3) produced much higher levels of DAF-2 monitored NO and nitrite than did L-ArgGal under the same experimental conditions. In conclusion, these results indicate that an increase in the cell permeation of L- and D-arginine by L-ArgGal and D-ArgGal can lead to an increase in NO levels.
A 600-MHz Single-Chip Multiprocessor With 4.8-GB/s Internal Shared Pipelined Bus and 512-kB Internal Memory (2004)

A 600-MHz single-chip multiprocessor, which includes two M32R 32-bit CPU cores , a 512-kB shared SRAM and an internal shared pipelined bus, was fabricated using a 0.15-/spl mu/m CMOS process for embedded systems. This multiprocessor is based on symmetric multiprocessing (SMP), and supports modified-exclusive-shared-invalid (MESI) cache coherency protocol. The multiprocessor inherits the advantages of previously reported single-chip multiprocessors, while its multiprocessor architecture is optimized for use as an embedded processor. The internal shared pipelined bus has a low latency and large bandwidth (4.8 GB/s). These features enhance the performance of the multiprocessor. In addition, the multiprocessor employs various low-power techniques. The multiprocessor dissipates 800 mW in a 1.5-V 600-MHz multiprocessor mode. Standby power dissipation is less than 1.5 mW at 1.5 V. Hence, the multiprocessor achieves higher performance and lower power consumption. This paper presents a single-chip multiprocessor architecture optimized for use as an embedded processor and its various low-power techniques.
Nanoengineering gold particle composite fibers for cardiac tissue engineering (2013)

Gold nanostructures can be incorporated into macroporous scaffolds to increase the matrix conductivity and enhance the electrical signal transfer between cardiac cells. Here we report a simple approach for fabricating 3-dimensional (3D) gold nanoparticle (NP)-based fibrous scaffolds, for engineering functional cardiac tissues generating a strong contraction force. A polycaprolactone-gelatin mixture was electrospun to obtain fibrous scaffolds with an average fiber diameter of 250 nm. In a facile method, gold NPs were evaporated on the surface of the fibers, creating nanocomposites with a nominal gold thickness of 2, 4, and 14 nm. Compared to pristine scaffolds, cardiac cells seeded on the nano-gold scaffolds assembled into more elongated and aligned tissues. The gold NPs on the fibers were able to maintain the ratio of cardiomyocytes to fibroblasts in the culture, to encourage the growth of cardiomyocytes with significantly higher aspect ratio, and promote massive cardiac sarcomeric actinin expression. Finally, engineering cardiac tissues within gold NP-based scaffolds exhibited significantly higher contraction amplitudes and rates, as compared to scaffolds without gold. We envision that cardiac tissues engineered within these gold NP scaffolds can be used to improve the function of the infarcted heart.
A Self‐Administered Technique for the Detection of Sexually Transmitted Diseases in Remote Communities (1997)

The control of sexually transmitted diseases (STDs) in remote rural communities would be enhanced by a sensitive self-administered method for the detection of asymptomatic infection. Results of conventional methods for the detection of STDs were compared with results of tampon-collected specimens analyzed by polymerase chain reaction (PCR) for 480 women. Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis were detected by routine methods in 4 (1%), 14 (3%), and 41 (9%) samples, respectively, while PCR detected these organisms from 52 (11%), 26 (5%), and 75 (16%) tampons, respectively. The detection of each organism was significantly greater by PCR in tampon-collected samples than by routine conventional methods (P < .01). Discrepant results were confirmed by separate primers in 40 of 48 specimens for N. gonorrhoeae, in 11 of 12 specimens for C. trachomatis, and in 31 of 32 specimens for T. vaginalis. Tampons tested by PCR provide an acceptable and sensitive method for detection of STDs in women living in remote areas.
High-loading Fe<sub>2</sub>O<sub>3</sub>/SWNT composite films for lithium-ion battery applications (2017)

Single-walled carbon nanotube (SWNT) films are a potential candidate as porous conductive electrodes for energy conversion and storage; tailoring the loading and distribution of active materials grafted on SWNTs is critical for achieving maximum performance. Here, we show that as-synthesized SWNT samples containing residual Fe catalyst can be directly converted to Fe<sub>2</sub>O<sub>3</sub>/SWNT composite films by thermal annealing in air. The mass loading of Fe<sub>2</sub>O<sub>3</sub> nanoparticles is tunable from 63 wt% up to 96 wt%, depending on the annealing temperature (from 450 °C to 600 °C), while maintaining the porous network structure. Interconnected SWNT networks containing high-loading active oxides lead to synergistic effect as an anode material for lithium ion batteries. The performance is improved consistently with increasing Fe<sub>2</sub>O<sub>3</sub> loading. As a result, our Fe<sub>2</sub>O<sub>3</sub>/SWNT composite films exhibit a high reversible capacity (1007.1 mA h g<sup>-1</sup> at a current density of 200 mA g<sup>-1</sup>), excellent rate capability (384.9 mA h g<sup>-1</sup> at 5 A g<sup>-1</sup>) and stable cycling performance with the discharge capacity up to 567.1 mA h g<sup>-1</sup> after 600 cycles at 2 A g<sup>-1</sup>. The high-loading Fe<sub>2</sub>O<sub>3</sub>/SWNT composite films have potential applications as nanostructured electrodes for various energy devices such as supercapacitors and Li-ion batteries.
Modeling of correlated failures and community error recovery in multiversion software (1990)

Three aspects of the modeling of multiversion software are considered. First, the beta-binomial distribution is proposed for modeling correlated failures in multiversion software. Second, a combinatorial model for predicting the reliability of a multiversion software configuration is presented. This model can take as inputs failure distributions either from measurements or from a selected distribution (e.g. beta-binomial). Various recovery methods can be incorporated in this model. Third, the effectiveness of the community error recovery method based on checkpointing is investigated. This method appears to be effective only when the failure behaviors of program versions are lightly correlated. Two different types of checkpoint failure are also considered: an omission failure where the correct output is recognized at a checkpoint but the checkpoint fails to correct the wrong outputs and a destructive failure where the good versions get corrupted at a checkpoint.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Bioactive Fullerene Peptide (1994)

The highly hydrophobic C60 (buckminsterfullerene) was water solubilized by covalently linking the synthon 1,2-dihydro-1,2-methanofullerene [60]-61-carboxylic acid to the alpha-amino group of the hydrophilic 4-8 sequence of peptide T, known to display potent human monocyte chemotaxis. The resulting compound, characterized by a variety of analytical techniques, including a UV spectrum in aqueous solution, exhibits remarkable chemotactic potency, comparable to that of the parent pentapeptide. Furthermore, this fullerene-peptide conjugate inhibits, albeit weakly, HIV-1 protease.
Rock densities and vertical gradient of gravity in the Earth's crust (1963)

The Mohole project now under way brings up an important problem involving the rate of change of the gravitational field through the crust of the earth down to the Mohorovicic discontinuity. If measurements of the vertical gradient of gravity in the Mohole are feasible, direct determinations of in situ densities of rock formations penetrated by the borehole will be accomplished [Hammer, 1950; Smith, 1950; Domzalski, 1953–1954; Miller and Innes, 1953]. This is one of the major problems in the presently very active study of the structure of earth's crust [Ewing and Press, 1956; Press, 1961; Woollard, 1959].

An instrument to measure gravity or the gravitational gradient in a borehole is of interest in exploration geophysics, but construction of such an instrument presents formidable design problems and has not yet been brought to successful, practical fruition [Gilbert, 1952; Dolbear, 1959]. However the precision requirements to obtain more generalized, but important, results in the Mohole conceivably could be within reach. Furthermore, the problem of collecting representative rock samples from the Mohole for measurements in the laboratory may be no less difficult [Hammer, 1950].
The Hospital's Obligation to Protect Patients from Carriers of Infectious Diseases (1979)

Nosocomial infection is a serious problem in hospitals and other inpatient health care facilities. It has been receiving increasing attention in the medical literature since the first outbreaks of penicillin-resistant staphylococcal infections were recognized in the 1950s. The medical profession has been forced to acknowledge, albeit reluctantly, that infectious diseases are not going to be eradicated by the administration of antibiotics and antimicrobials alone. Microogranisms have shown amazing resilience in their ability to protect themselves against the most sophisticated drugs in our armamentarium by the formation of resistant strains. Further, organisms which were never believed to cause disease in the pre-antibiotic era are now linked with devastating infections in seriously ill hospitalized patients. Even the organisms commonly found on the skin of a healthy person can cause disease given the right set of circumstances. A carrier, however, is a person who harbors a specific pathogenic organism, yet fails to exhibit any discernible symptom of the disease. Nonetheless, the carrier is capable of spreading the organism to others.
Learning classifiers for misuse and anomaly detection using a bag of system calls representation (2005)

In this paper, we propose a "bag of system calls" representation for intrusion detection in system call sequences and describe misuse and anomaly detection results with standard machine learning techniques on University of New Mexico (UNM) and MIT Lincoln Lab (MIT LL) system call sequences with the proposed representation. With the feature representation as input, we compare the performance of several machine learning techniques for misuse detection and show experimental results on anomaly detection. The results show that standard machine learning and clustering techniques on simple "bag of system calls" representation of system call sequences is effective and often performs better than those approaches that use foreign contiguous subsequences in detecting intrusive behaviors of compromised processes.