gebhart/patrepeval huggingface dataset:
Handover probability database for optimization of mobility between UMTS and WLAN (2006)

Most handover algorithms between UMTS and WLAN networks require coverage information obtained by mobile terminal measurements. However, nothing is currently forecast in standards to ease these potentially costly measurements. We therefore propose a handover probability database used to compute, for each mobile terminal, the identity of the most probable UMTS cells and WLAN Access Points for inter-system handover. Handover probability database results may be either one element for blind handover, or a neighboring list to limit mobile terminal's measurements to the most probable cells or Access Points. The method is assessed with a dynamic simulation tool. Blind handover from UMTS to WLAN using the handover probability database shows good performance, compared with direct blind handover. The neighboring cell list size is importantly restricted, in both directions. The handover probability database can be combined with handover or reselection algorithms, at different levels of UMTS -WLAN inter- working architecture.
A High-Rate, High-Capacity, Nanostructured Tin Oxide Electrode (1999)

Recently, battery anodes derived from oxides of tin have been of considerable interest because they can, in principle, store more than twice as much as graphite. However, large volume changes occur when is inserted and removed from these materials, and this causes internal damage to the electrode resulting in loss of capacity and rechargeability. We describe here a nanostructured electrode that has extraordinary rate capabilities, can deliver very high capacities , and still retain the ability to be discharged and recharged for as many as 800 cycles. These electrodes, prepared via the template method, consist of monodisperse nanofibers protruding from a current‐collector surface like the bristles of a brush. The dramatically improved rate and cycling performance are related to the small size of the nanofibers that make up the electrode and the small domain size of the grains within the nanofibers. ©2000 The Electrochemical Society
Hinged Hydrostatic Transducers. (1984)

The initial proposal for this work was to prepare trial conformal hydrophones based on hinged arrays of individual transducer elements of three basic types. Choice of elements was based on previous work with composite transducers and consideration of sensitivity and durability. Polyurethane was chosen as a hinging material because it was an elastomer that had been used in other composite applications. Later this material was replaced by a flexable epoxy material that showed improved polymer/ceramic bonding, excellent self-bonding, and increased pot life. Many variations of element design were tested in 1 in. x 1 in. arrays. Variations in elastomer hardness were tested. Different fillers were incorporated in the hinging material to make it hydrostatically compressible. Along with this work two flexable electrode systems were developed, for use with polyurethane and epoxy based polymers. (Author)
The genetics of asthma (1998)

The genetic approach to asthma has revealed a few candidate genes. Among them, special attention is given to the association between chromosome 5q and various cytokines and also to chromosome 11q and the IgE receptor. A mutation in chromosome 5 enhances interleukin-4 activity, which increases IgE synthesis by plasma cells. Polymorphism in the beta chain of the high-affinity IgE receptor (FC epsilonRI-beta) is considered to play a key role in the pathogenesis of asthma. Increased IgE, caused by both mutations, is responsible for inflammatory allergic reactions. A possible link between genetics and asthma has been suggested, although some studies could not confirm an association. Further study of the candidate genes may allow at-risk individuals to be tested and new treatments to be developed.
Proteomic analysis of Lyme disease: Global protein comparison of three strains of <b><i>Borrelia burgdorferi</i></b> (2005)

The Borrelia burgdorferi spirochete is the causative agent of Lyme disease, the most common tick-borne disease in the United States. It has been studied extensively to help understand its pathogenicity of infection and how it can persist in different mammalian hosts. We report the proteomic analysis of the archetype B. burgdorferi B31 strain and two other strains (ND40, and JD-1) having different Borrelia pathotypes using strong cation exchange fractionation of proteolytic peptides followed by high-resolution, reversed phase capillary liquid chromatography coupled with ion trap tandem mass spectrometric analysis. Protein identification was facilitated by the availability of the complete B31 genome sequence. A total of 665 Borrelia proteins were identified representing approximately 38% coverage of the theoretical B31 proteome. A significant overlap was observed between the identified proteins in direct comparisons between any two strains (>72%), but distinct differences were observed among identified hypothetical and outer membrane proteins of the three strains. Such a concurrent proteomic overview of three Borrelia strains based upon only the B31 genome sequence is shown to provide significant insights into the presence or absence of specific proteins and a broad overall comparison among strains.
Lithium-Doped Gallium Arsenide Tunnel Diodes (1964)

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Supramolecular chemistry as an underpinning concept (2015)

I always feel a bit guilty in describing myself as a supramolecular chemist. While in the scientific literature supramolecular chemistry has been enduringly popular (or perhaps more accurately, pap...
Novel biobased epoxy compounds: epoxidized sucrose esters of fatty acids (2011)

Novel biobased high functionality epoxy resins were synthesized by the epoxidation of sucrose ester resins of vegetable oil fatty acids (SEFA). A series of sucrose esters of fatty acids were epoxidized by peracetic acid generated in situ from hydrogen peroxide and acetic acid in the presence of an ion exchange resin catalyst to produce the epoxidized sucrose esters of fatty acids (ESEFA). The conversion of double bonds to epoxides was greater than 99%. The products were characterized by matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) mass spectrometry, Fourier-transform infrared (FTIR) spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy. The physical properties were characterized using bulk viscosity, intrinsic viscosity, and density measurements. The thermal properties were characterized by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Since sucrose esters consist of a sucrose core fully substituted with eight vegetable oil fatty acids, both SEFAs and ESEFAs possess well-defined compact macromolecular structures. As novel biobased epoxy compounds, ESEFAs possess high epoxy functionality (8–15 per molecule), high density, and a compact molecular structure. Thus, ESEFAs are very promising in a number of uses from the formation of biobased thermosets by crosslinking of the epoxy groups, to further derivatization by reaction of the epoxy groups.
Quantitative Studies on the Melittin-Induced Leakage Mechanism of Lipid Vesicles (1998)

We have investigated, both experimentally and theoretically, the efflux of carboxyfluorescein (a self-quenching fluorescent dye) from vesicles of different sizes and lipid species (POPC, DOPC) after having added the bee venom peptide melittin. This comprises quantitative analyses regarding the extent of lipid-associated peptide, the mode as well as the temporal progress of dye release and the possible leakage mechanism. Our results indicate a graded efflux characterized by a single-pore retention factor reflecting the formation of pores whose lifetimes are rather small (millisecond range). The observed fluorescence signal arising from the dequenching of effluent dye has been converted to the number of pore openings over the course of time. All the resulting curves exhibit a pronounced slowing down of the pore formation rate revealing two distinct relaxation steps at about 20 and 200 s, respectively, being largely independent of vesicle type and peptide to lipid ratio. The pore formation rate itself increases in proportion to the amount of membrane bound peptide. We give a quantitative account of our experimental findings based on a novel reaction scheme applicable to any of our various liposome systems. It implies that the pore formation rate is controlled by a passage through two intermediate monomeric peptide states. These states are thought to become well populated in the initial stage of lipid bilayer perturbation, but would practically die out after some time owing to a restabilization of the membrane system.
Pharmacokinetic Evaluation and Safety Profile of a 15‐Minute Versus 30‐Second Infusion of Palonosetron in Healthy Subjects (2006)

Palonosetron is a potent, selective 5-HT(3) receptor antagonist effective in the prevention of acute and delayed chemotherapy-induced nausea and vomiting. In practice, 5-HT(3) receptor antagonists, including palonosetron, are often coadministered with dexamethasone over approximately 15 minutes, although the approval of palonosetron was based on administration as a 30-second infusion. This open-label, randomized, 2-way crossover trial compared the pharmacokinetics and safety of palonosetron 0.25 mg administered as a 15-minute 50-mL intravenous infusion with a 30-second 5-mL infusion. Aside from an anticipated 40% decrease in maximum plasma concentration after a 15-minute infusion, the pharmacokinetics of palonosetron (including area under the plasma concentration-time curve [AUC], plasma elimination half-life, total body clearance, and apparent volume of distribution at steady state) were similar for both treatments. Both treatments were well tolerated, with no significant changes in vital signs or electrocardiograms. Palonosetron infused over 15 minutes is well tolerated, with an AUC(0-infinity) equivalent to a 30-second infusion.
An Experimental and Modeling Study of Cordierite Traps - Pressure Drop and Permeability of Clean and Particulate Loaded Traps (2000)

<div class="htmlview paragraph">A model for calculating the trap pressure drop, particulate mass inside the trap and various particulate and trap properties was developed using the steady-state data and the theory developed by Konstandopoulos &amp; Johnson, 1989. Changes were made with respect to the calculation of clean pressure drop, particulate layer porosity and the particulate layer permeability. This model was validated with the data obtained from the steady-state data run with different traps supplied by Corning Inc. The data were collected using the 1988 Cummins L-10 heavy-duty diesel engine using No.2 low sulfur diesel fuel. The three different traps were EX 80 (100 cell density), EX 80 (200 cell density) and EX 66 (100 cell density) all with a 229 mm diameter and 305 mm length. These traps were subjected to different particulate matter loadings at different speeds. The traps were not catalyzed. Subsequent loadings were performed without baking the trap in between to validate the pressure drop model with a certain amount of particulate mass already present in the trap. The pressure drop performance of the three traps were different from each other as they had different properties. The initial building up of particulate mass inside the EX 66 was different from other traps, because it had a larger pore size when compared to the EX 80. The model was able to predict this behavior by allowing a certain amount of particulate mass into the wall during the initial hours of loading followed by the building up of a particulate layer thereby increasing the pressure drop.</div> <div class="htmlview paragraph">Regeneration experiments were also performed with all the traps to determine the regeneration efficiency of these traps at different loading conditions. Filtration efficiency of the traps was determined experimentally by measuring the raw exhaust solid particulate matter concentration upstream and downstream of the trap.</div>
Recent advances in exploitation geophysics (1989)

In today’s climate of dwindling domestic reserves and relatively low oil prices, many companies are focusing on increasing reserves by more detailed characterization and precise definition of mature fields. Analyses by the Bureau of Economic Geology indicate that, excluding Alaska, up to 80 billion bbl oil and 180trillionft3 gas can be added to current US onshore reserves by infill drilling, extension drilling, and well recompletion, but only if this work is based on detailed geologic evaluations. Because of the increasing importance in developing mature fields, detailed production strategies must be devised that incorporate all available geologic, geophysical, and engineering data.
Recent Trends in FPGA Architectures and Applications (2008)

Since their introduction in the 1985, field programmable gate arrays (FPGAs) have become increasingly important to the electronics industry. They have the potential for higher performance and lower power consumption than microprocessors and compared with application specific integrated circuits (ASICs), offer lower non-recurrent engineering (NRE) costs, reduced development time, easier debugging and reduced risk. Since modern FPGAs can meet many of the performance requirements of ASICs, they are being increasingly used in their place. In this paper, some recent developments in FPGA devices, platforms and applications are reviewed, with a focus on high performance applications of this technology.
Shigella actin-based motility in the absence of vinculin (1997)

Reports on the role of vasodilator-stimulated phosphoprotein (VASP) and proline-rich sequences in actin-based motility of Listeria and potentially of Shigella flexneri have led to the suggestion that vinculin might be an essential docking protein on the surface O2 motile Shigella. Therefore, whether vinculin had a functional role in Shigella actin-based motility was tested by examining Shigella infection of the vinculin-deficient F9 cell line variant 5.51. Shigella are able to form actin tails and surface protrusions in 5.51 cells that are indistinguishable from those they produce in F9 cells, and Shigella rates of intracellular movement and protrusion formation are similar in the two cell lines. These data disprove the model of Shigella actin-based motility in which vinculin is an essential docking protein for either the formation of actin tails or the acceleration of motile bacteria.
Single- and dual-ion-beam sputter deposition of titanium oxide films (1998)

The optical properties and the surface morphologies of single-ion-beam sputtering (SIBS) and dual-ion-beam sputtering (DIBS) depositions of titanium oxide films are investigated and compared. In the DIBS process, the ion-assisted deposition by the voltage of a low ion beam ranged from 50 to 300 V at a 0% and 44% oxygen percentage. Cosputtering with materials of Si, SiO(2) (fused silica), and Al is also utilized in SIBS to improve amorphous-structure film. For the low-absorption and surface-roughness film, the optimum deposition condition of DIBS and postdeposition baking temperature for SIBS and DIBS are essential to the process.
Aportaciones al estudio en secundaria de la mujer en el sistema feudal (2004)

El estudio de una historia global conlleva necesariamente la inclusion de la mujer, es decir, la introduccion en la ensenanza de la variable genero. Sin embargo, a este aspecto no se le presta la atencion necesaria en los curricula de Ciencias Sociales.
Esta comunicacion pretende aportar algunas ideas para la ensenanza en secundaria de la mujer en el sistema feudal a traves de textos e imagenes, tanto en formato tradicional como en digital. En los planes educativos actuales, la ensenanza de este aspecto se llevaria a cabo en segundo curso del primer ciclo de la ESO.
La comunicacion esta dividida fundamentalmente en dos partes: la consideracion de la mujer en la Edad Media y los diversos tipos de mujeres en el sistema feudal
Estradiol activation of human colon carcinoma-derived Caco-2 cell growth. (1996)

This is the first report on estrogen-dependent growth of human-derived colon carcinoma cells. Under selected conditions, growth of subconfluent Caco-2 cells is triggered by estradiol. Cell growth is estradiol concentration dependent, with maximal effect occurring at about 0.4 nM. Growth is prevented by two different antiestrogens: the partial agonist, OH-Tamoxifen, and the pore antagonist, ICI 182,780. The growth effect is specific for estradiol since other hormonal steroids tested do not affect cell growth. The amount of estradiol receptor in subconfluent Caco-2 cells, detected by blot with monoclonal antibodies directed against the receptor as well as estradiol binding assays, is similar to that of the classical estradiol-responsive, human mammary cancer-derived MCF-7 cells. Estradiol treatment of subconfluent Caco-2 cells rapidly and reversibly stimulates four important intermediates in a signal transduction pathway that is known to trigger cell proliferation: two members of the large family of c-src-related tyrosine kinases, c-src and c-yes, and two serine/threonine kinases, the mitogen-activated protein (MAP) kinases, erk-1 and erk-2. Tyrosine kinases activated by estradiol are up-stream MAP kinases and Caco-2 cell proliferation. In fact, genistein, a specific tyrosine kinase inhibitor, abolishes the estradiol stimulatory effect on both erk-2 activity and cell proliferation. Our findings show that in subconfluent Caco-2 cells, the estradiol-receptor complex activates the c-src, c-yes/MAP kinase pathway and activates growth. This could have important implications for the understanding of human intestinal carcinogenesis.
FcγRII (CD32) Is Linked to Apoptotic Pathways in Murine Granulocyte Precursors and Mature Eosinophils (1997)

Murine granulocytes and precursors express low-affinity IgG Fc receptors (Fc gammaR). We investigated the effects of FcyR ligation on the development of eosinophils in cultures of normal murine bone marrow. Eosinophilopoiesis was induced by culture of bone marrow cells in the presence of cytokines (granulocyte-macrophage colony-stimulating factor [GM-CSF], interleukin-3 [IL-3], and IL-5). Addition to the cultures of 2.4G2, a rat monoclonal antibody (mAb) that reacts with Fc gammaRII (CD32) and Fc gammaRIII (CD16), induced granulocyte apoptosis within 24 hours. Granulocytes in cultures that contained 2.4G2 showed chromatin condensation, binding of Annexin-V, and fas induction, and by electron microscopy, apoptosis was most commonly observed in cells of the eosinophil lineage. Since murine granulocytes can express both Fc gammaRII (CD32) and Fc gammaRIII (CD16), we investigated the effect of 2.4G2 on cultures of bone marrow obtained from Fc gammaRIII (CD16) gene-disrupted mice and found that the apoptosis induced with 2.4G2 was CD16-independent. Studies with bone marrow cultures from B6MLR-lpr/lpr and C3H/HEJ-gld/gld mice established that the Fc gammaRII (CD32)-triggered apoptosis was fas-fasL-dependent. When mature eosinophils isolated from hepatic granulomas of Schistosoma mansoni-infected mice were cultured in cytokines in the presence of 2.4G2, the eosinophils underwent apoptosis within 24 hours. These findings identify a previously unknown linkage between Fc gammaR on eosinophils and fas-mediated apoptosis, a connection that could be relevant to mechanisms by which eosinophils mediate tissue injury and antibody-dependent cellular cytotoxicity reactions.
Targeted Synthesis of a Porous Aromatic Framework with High Stability and Exceptionally High Surface Area (2009)

Diamantenfieber: Ein Diamantgerüst, in dem C-C-Bindungen gegen Benzolringe ausgetauscht sind (siehe Bild), ist einerseits stabil und hat andererseits eine große innere Oberfläche. Das poröse aromatische Gerüst PAF-1 (Oberfläche 7100 m2 g−1) kann große Mengen an Wasserstoff und Kohlendioxid, Benzol- und Toluoldampf aufnehmen. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Rapid creation of <i>Arabidopsis</i> doubled haploid lines for quantitative trait locus mapping (2012)

Quantitative trait loci (QTL) mapping is a powerful tool for investigating the genetic basis of natural variation. QTL can be mapped using a number of different population designs, but recombinant inbred lines (RILs) are among the most effective. Unfortunately, homozygous RIL populations are time consuming to construct, typically requiring at least six generations of selfing starting from a heterozygous F(1). Haploid plants produced from an F(1) combine the two parental genomes and have only one allele at every locus. Converting these sterile haploids into fertile diploids (termed "doubled haploids," DHs) produces immortal homozygous lines in only two steps. Here we describe a unique technique for rapidly creating recombinant doubled haploid populations in Arabidopsis thaliana: centromere-mediated genome elimination. We generated a population of 238 doubled haploid lines that combine two parental genomes and genotyped them by reduced representation Illumina sequencing. The recombination rate and parental allele frequencies in our population are similar to those found in existing RIL sets. We phenotyped this population for traits related to flowering time and for petiole length and successfully mapped QTL controlling each trait. Our work demonstrates that doubled haploid populations offer a rapid, easy alternative to RILs for Arabidopsis genetic analysis.
Experience with a new ureteral stent made of a biocompatible copolymer. (1988)

A double-pigtail ureteral stent made from a biocompatible copolymer was designed for antegrade insertion with a new coaxial system. Thirty-eight of these stents were successfully placed in 33 patients. Of eight stents used for benign temporary indications, two (two patients) occluded prematurely. One of these patients had retained stone fragments, which caused the 10-F stent to occlude 4 months after balloon dilation of a midureteral stricture. The second patient had a ureteroconduit stricture that was dilated and stented, but mucus occluded the 10-F stent 5 days after insertion. In 25 of the patients, 30 stents were placed for ureteral obstruction due to malignant neoplasms. Three patients died with patent stents, while surviving patients with malignancies continue to have functioning stents, for an overall mean patency of 5.1 months in these patients. No problems related to stent migration or brittleness have been encountered.
Graph-Theoretic Scagnostics (2006)

We introduce Tukey and Tukey scagnostics and develop graphtheoretic methods for implementing their procedure on large datasets.
A model for the computer analysis of synchronous DNA distributions obtained by flow cytometry (1980)

A new model for obtaining the distributions of cells in the cell cycle by computer analysis of flow cytometry data is proposed. The model is able to analyze distributions from both asynchronous and synchronous cell populations. A culture of HeLa cells is pulse-labeled with tritiated thymidine at various times after synchronization by the mitotic selection method, then analyzed by flow cytometry and autoradiography. The results show good agreement between the percentage S-phase cells determined by the model and by autoradiography.