gebhart/patrepeval huggingface dataset:
Analysis and Optimization of a Piezoelectric Harvester on a Car Damper (2015)

Low power levels obtained from piezoelectric conversion of ambient vibrations appear to be a promising solution to supply wireless sensors embedded inside automotive suspension. However such a solution requires overall an optimum power extraction from the piezoelectric power harvester. This leads to the use of a sufficiently accurate and flexible modelling method to find the optimal characterics and configuration of the harvester. To this end, an innovative bond graph model of the piezoelectric harvester embedded in the quarter vehicle system is proposed for providing the harvested power when a car travels a road with a speed bump at 30 km/h. Results show that around of 0.5 milliwatt electrical power is harvested when varying key parameters like the location and characteristics of the piezoelectric device.
Antihyperlipidemic Effect of Crocin Isolated from the Fructus of Gardenia jasminoides and Its Metabolite Crocetin (2005)

The pancreatic lipase inhibitors were isolated from the fructus of Gardenia jasminoides ELLIS, and their antihyperlipidemic activities were measured. Gardeniae fructus (GF) water extract inhibited pancreatic lipase activity. Crocetin and crocin were isolated from GF water extract as inhibitors of pancreatic lipase with an IC50 value of 2.1 and 2.6 mg/ml (triolein as a substrate). Crocin and crocetin significantly inhibited the increase of serum TG level in corn oil feeding-induced triglyceridemic mice, as well as that of serum triglyceride and total and LDL cholesterol levels in Triton WR-1339-induced hyperlipidemic mice. These compounds also showed hypolipidemic activity in hyperlipidemic mice induced by high cholesterol, high fat or high carbohydrate diets for 5 weeks. The results suggest that the hypolipidemic activity of GF and its component crocin may be due to the inhibition of pancreatic lipase and crocin, and its metabolite, crocetin, can improve hyperlipidemia.
Measurement of the pH of Frozen Buffer Solutions by Using pH Indicators (1977)

A method was established to estimate the pH change of several buffer solutions on freezing by using a combination of pH indicators. Among more than 30 buffer solutions examined, almost half exhibited a pH change in the temperature range between freezing point and 220°K; the results were tabulated. Glycerol was found to suppress the pH changes because of its “salt buffer” effect.
Structural Basis of Protein Kinase C Isoform Function (2008)

Protein kinase C (PKC) isoforms comprise a family of lipid-activated enzymes that have been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised of a regulatory domain (that contains the membrane-targeting motifs that respond to lipid cofactors, and in the case of some PKCs calcium) and a relatively conserved catalytic domain that binds ATP and substrates. These enzymes are coexpressed and respond to similar stimulatory agonists in many cell types. However, there is growing evidence that individual PKC isoforms subserve unique (and in some cases opposing) functions in cells, at least in part as a result of isoform-specific subcellular compartmentalization patterns, protein-protein interactions, and posttranslational modifications that influence catalytic function. This review focuses on the structural basis for differences in lipid cofactor responsiveness for individual PKC isoforms, the regulatory phosphorylations that control the normal maturation, activation, signaling function, and downregulation of these enzymes, and the intra-/intermolecular interactions that control PKC isoform activation and subcellular targeting in cells. A detailed understanding of the unique molecular features that underlie isoform-specific posttranslational modification patterns, protein-protein interactions, and subcellular targeting (i.e., that impart functional specificity) should provide the basis for the design of novel PKC isoform-specific activator or inhibitor compounds that can achieve therapeutically useful changes in PKC signaling in cells.
<i>In vitro</i> Effect of Essential Oils and Isolated Mono- and Sesquiterpenes on <i>Leishmania major</i> and <i>Trypanosoma brucei</i> (2000)

The effect of different essential oils as well as of isolated mono- and sesquiterpenes on the viability of bloodstream forms of Trypanosoma brucei, promastigotes of Leishmania major and human HL-60 cells was evaluated using the Almar Blue assay. Of the 12 essential oils and 8 terpenes investigated, only three essential oils, Melissa officinalis (balmmint) oil, Thymus vulgaris (thyme) oil, and Melaleuca alternifolia (tea tree) oil were about 50-fold and 80-fold more toxic to bloodstream forms of T. brucei than to HL-60 cells, respectively. Terpinen-4-ol, the main compound of the Australian tea tree oil, was even 1000-fold more toxic to trypanosomes than to the human cells. On the other hand, none of the essential oils and terpenes tested were more toxic to promastigotes of L. major than to HL-60 cells.
Prediction-Based Dynamic Resource Allocation for Video Transcoding in Cloud Computing (2013)

This paper presents prediction-based dynamic resource allocation algorithms to scale video transcoding service on a given Infrastructure as a Service cloud. The proposed algorithms provide mechanisms for allocation and deallocation of virtual machines (VMs) to a cluster of video transcoding servers in a horizontal fashion. We use a two-step load prediction method, which allows proactive resource allocation with high prediction accuracy under real-time constraints. For cost-efficiency, our work supports transcoding of multiple on-demand video streams concurrently on a single VM, resulting in a reduced number of required VMs. We use video segmentation at group of pictures level, which splits video streams into smaller segments that can be transcoded independently of one another. The approach is demonstrated in a discrete-event simulation and an experimental evaluation involving two different load patterns.
Evidence for prolactin as the main luteotrophic factor in the cyclic dog (1990)

The role of prolactin and LH in the control of the function of the corpus luteum in the dog was studied. Experiments were performed to interfere with the secretion of a) prolactin by administering a dopamine agonist and b) LH by desensitisation with a long-acting LHRH and by stimulation. Treatments with prolactin-lowering dosages of bromocriptine, (20 micrograms/kg body weight twice a day, orally; n = 8) which started between day 1-5 (n = 4) and day 20-24 (n = 4) of the luteal period resulted in a similar pattern of progesterone, concentration in peripheral blood in both groups. The progesterone release in the second half of the luteal period (13.1 +/- 1.8% (sem) of the progesterone release of the total luteal period) was significantly lower than in control dogs (24.7 +/- 2.2%). Treatment at about day 30 of the luteal period with LHRH CR (1.34 mg, intramuscularly; n = 3), which significantly suppressed the LH level, did not reduce the progesterone release in the second half of the luteal period, 21.3 +/- 4.7% compared to 24.7 +/- 2.2% in the control dogs. The endogenous LH peak resulting from treatment with LHRH had no effect on the progesterone concentration in the blood. It is concluded that prolactin is the main luteotrophic factor in the cyclic dog during the second half of the luteal period.
Beyond 1 Tb/s Intra-Data Center Interconnect Technology: IM-DD OR Coherent? (2019)

We discuss technology options and challenges for scaling intra-datacenter interconnects beyond 1 Tb/s bandwidths, with focus on two possible approaches: pulse amplitude modulation (PAM)-based intensity modulation-direct detection (IM-DD) and baud-rate sampled coherent technology. In our studies, we compare the performance of various orders of PAM modulation (PAM4 to 8). In addition to these fixed PAM signaling options, a flexible PAM (FlexPAM) technique leveraging granularity in spectral efficiency (SE) is proposed to maximize link margin. For baud-rate sampled coherent technology, we propose a simplified digital signal processing (DSP) architecture to bring down power consumption of the coherent approach closer to that of IM-DD PAM. We also propose two new phase noise tolerant 2D coherent modulation formats to relax the laser linewidth requirement. In closing, a comparative study of fixed IM-DD PAM versus coherent polarization multiplexed-quadrature amplitude modulation (PM-QAM) is presented for a 1.6 Tb/s solution (200 Gb/s per dimension), with consideration of link loss/reach budget, power consumption, implementation complexity, as well as fan-out granularity.
Tissue Levels of Bone Resorptive Cytokines in Periodontal Disease (1991)

The levels of 3 bone resorptive cytokines, interleukin 1 alpha (IL-1 alpha), IL-1 beta, and tumor necrosis factor alpha (TNF alpha), were assessed in tissues from sites of periodontal disease. As determined by ELISA of tissue extracts, IL-1 beta and TNF alpha were detected in all diseased sites, whereas IL-1 alpha was present in 8/22 sites, IL-1 beta was present in highest concentration (mean +/- SEM: 11,695 +/- 2,888 pg/ml; 672 pM), followed by TNF alpha (434 +/- 135 pg/ml; 26 pM), and IL-1 alpha (342 +/- 160 pg/ml; 20 pM). The levels of all 3 mediators were significantly lower in clinically healthy tissues. There was a highly significant correlation between levels of IL-1 beta and TNF alpha (rs = 0.61, P less than 0.001), suggesting coordinated expression of these 2 mediators. The numbers of cells containing each mediator was also determined by indirect immunofluorescence on frozen tissue sections. Consistent with findings from tissue extracts, IL-1 beta-containing cells were present in approximately 5-fold higher numbers than TNF alpha-containing cells, and 40-fold higher numbers than IL-1-alpha-containing cells. Taken together with previous findings, these results indicate that IL-1 beta is likely to be an important mediator in the pathogenesis of periodontal disease.
Artificial Zinc Finger Peptide Containing a Novel His<sub>4</sub> Domain (2000)

Zinc finger constitutes one of the most common DNA binding motifs. Although zinc finger proteins consisting of Cys2His2, Cys3His, Cys4, and Cys6 domains are known in nature, a novel His4 zinc finger protein has never been observed. Herein, we have created the first artificial His4-type zinc finger protein (H4Sp1) engineered by Cys → His mutations of the Cys2His2-type zinc finger transcription factor Sp1. The CD features of the single finger H4Sp1f2 and three-finger H4Sp1 clearly demonstrate the folding of the mutant His4 peptides by complexation with Zn(II). The NMR study of Zn(II)-H4Sp1f2 reveals that some distortions of the helical region occur due to Zn(II) coordination. The gel mobility shift assay and DNase I footprinting analysis strongly show the binding of Zn(II)-H4Sp1 to the GC-box site of duplex DNA. The methylation interference pattern of Zn(II)-H4Sp1 binding significantly resembles that of the corresponding C2H2Sp1 binding. The present artificial peptide H4Sp1 is the first example of a zinc finger containing the His4 domain. Of special interest is the fact that the zinc finger domains of H4Sp1 are folded (although not identical to the native structure) and bind DNA similar to wild-type C2H2Sp1.
Tumor-infiltrating CD45RO+ Memory T Lymphocytes Predict Favorable Clinical Outcome in Solid Tumors (2017)

The prognostic role of tumor-infiltrating CD45RO<sup>+</sup> memory T lymphocytes (CD45RO<sup>+</sup> T cells) in human solid tumors remains controversial. Herein, we conducted a meta-analysis including 25 published studies with 4720 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating CD45RO<sup>+</sup> T cells in human solid tumors. We found that CD45RO<sup>+</sup> T cell infiltration was significantly associated with improved overall survival (OS) and disease-free survival (DFS) in all types of solid tumors. In stratified analyses, CD45RO<sup>+</sup> T cell infiltration significantly improved 1-year, 3-year and 5-year OS in colorectal, gastric and esophageal cancer, but only 5-year OS in hepatocellular carcinoma. And these cells were positively associated with 1-year, 3-year and 5-year DFS in hepatocellular, colorectal and esophageal cancer. In addition, high density of intratumoral CD45RO<sup>+</sup> T cells inversely correlated with TNM stage of solid tumor. In conclusion, CD45RO<sup>+</sup> memory T lymphocyte infiltration leads to a favorable clinical outcome in solid tumors, implicating that it is a valuable biomarker for prognostic prediction for human solid malignances.
Preparation of N-Substituted 1-(3′,4′-Dihydroxyphenyl)-2-aminoethanols (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of N-Substituted 1-(3′,4′-Dihydroxyphenyl)-2-aminoethanolsJohn R. Corrigan, Marie-Jo. Langermann, and Maurice L. MooreCite this: J. Am. Chem. Soc. 1949, 71, 2, 530–531Publication Date (Print):February 1, 1949Publication History Published online1 May 2002Published inissue 1 February 1949https://pubs.acs.org/doi/10.1021/ja01170a044https://doi.org/10.1021/ja01170a044research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Introduction to Radiochemistry (1949)

This book is a teaching text for chemists. Considerable background in chemistry, calculus and newtonian and relativistic physics is necessary to appreciate fully the scope of this volume. Nevertheless, the authors have written the text in a lucid style that enables one with only a nodding acquaintance with higher mathematics to appreciate the principles set forth. Throughout the book the historical approach is used to introduce a subject. This lends interest to the discussion and ties the new material to the basic knowledge of the student. The subject of radiochemistry is introduced with a discussion of the three principal naturally occurring radioactive series of substances. A discussion of atomic and nuclear structure is followed by an excellent treatment of nuclear reactions. Sources of bombarding particles, such as alpha particles, electrons, neutrons and gamma radiations and their properties are discussed. The quantitative treatment of nuclear reactions receives attention, and it is
Synthesis and Membrane Binding Properties of a Lipopeptide Fragment from Influenza Virus A Hemagglutinin (2002)

Hemagglutinin from influenza virus A is a S-palmitoylated lipoglycoprotein in which the lipid groups are thought to influence the interaction between cell membrane and capsid during budding of viral offspring as well as fusion processes of the viral membrane with the endosome after entry of the viral particle into the cell. The paper describes the development of a method for the synthesis of characteristic lipidated hemagglutinin derived peptides which additionally carry the fluorescent 7-nitrobenz-2oxa-1,3-diazole (NBD) group. To achieve this goal the enzyme-sensitive para-phenylacetoxybenzyloxycarbonyl (PAOB) ester was developed. It is cleaved from the peptides and lipidated peptides under very mild conditions and with complete selectivity by treatment with the enzyme penicillin G acylase; this results in the formation of a phenolate. This intermediate spontaneously undergoes fragmentation thereby releasing the desired carboxylates. The combined use of this enzyme-labile fragmenting ester with the acid-labile Boc group, the Pd(0)-sensitive allyl ester and the corresponding Aloc urethane gave access to a mono-S-palmitoylated and a doubly S-palmitoylated NBD-labelled hemagglutinin peptide. The binding of these lipopeptides to model membranes was analyzed in a biophysical setup monitoring the transfer of fluorescent-labelled lipopeptide from vesicles containing the non-exchangeable fluorescence quencher Rho-DHPE to quencher-free vesicles. The experiments demonstrate that one lipid group is not sufficient for quasi-irreversible membrane insertion of lipidated peptides. This is, however, achieved by introduction of the bis-palmitoyl anchor. The intervesicle transfer always implies release of peptides localized at the outer face of the vesicles into solution followed by diffusion to and insertion into acceptor vesicles. For peptides bound at the inner face of the vesicle membrane, however, an additional flip-flop diffusion to the outer face has to occur beforehand. The kinetics of these processes were estimated by fast chemical quench of the outside fluorophores by sodium dithionite.
SKI-606, a Src/Abl Inhibitor with<i>In vivo</i>Activity in Colon Tumor Xenograft Models (2005)

Src up-regulation is a common event in human cancers. In colorectal cancer, increased Src levels are an indicator of poor prognosis, and progression to metastatic disease is associated with substantial increases in Src activity. Therefore, we examined the activity of SKI-606, a potent inhibitor of Src and Abl kinases, against colon tumor lines in vitro and in s.c. tumor xenograft models. SKI-606 inhibited Src autophosphorylation with an IC(50) of approximately 0.25 micromol/L in HT29 cells. Phosphorylation of Tyr(925) of focal adhesion kinase, a Src substrate, was reduced by similar concentrations of inhibitor. Antiproliferative activity on plastic did not correlate with Src inhibition in either HT29 or Colo205 cells (IC(50)s, 1.5 and 2.5 micromol/L, respectively), although submicromolar concentrations of SKI-606 inhibited HT29 cell colony formation in soft agar. SKI-606 also caused loosely aggregated Colo205 spheroids to condense into compact spheroids. On oral administration to nude mice at the lowest efficacious dose, peak plasma concentrations of approximately 3 micromol/L, an oral bioavailability of 18%, and a t(1/2) of 8.6 hours were observed. SKI-606 was orally active in s.c. colon tumor xenograft models and caused substantial reductions in Src autophosphorylation on Tyr(418) in HT29 and Colo205 tumors. SKI-606 inhibited HT29 tumor growth on once daily administration, whereas twice daily administration was necessary to inhibit Colo205, HCT116, and DLD1 tumor growth. These results support development of SKI-606 as a therapeutic agent for treatment of colorectal cancer.
Nanoscale layer-selective readout of magnetization direction from a magnetic multilayer using a spin-torque oscillator (2014)

Technology for detecting the magnetization direction of nanoscale magnetic material is crucial for realizing high-density magnetic recording devices. Conventionally, a magnetoresistive device is used that changes its resistivity in accordance with the direction of the stray field from an objective magnet. However, when several magnets are near such a device, the superposition of stray fields from all the magnets acts on the sensor, preventing selective recognition of their individual magnetization directions. Here we introduce a novel readout method for detecting the magnetization direction of a nanoscale magnet by use of a spin-torque oscillator (STO). The principles behind this method are dynamic dipolar coupling between an STO and a nanoscale magnet, and detection of ferromagnetic resonance (FMR) of this coupled system from the STO signal. Because the STO couples with a specific magnet by tuning the STO oscillation frequency to match its FMR frequency, this readout method can selectively determine the magnetization direction of the magnet.
Polarization control in ridge-waveguide-laser diodes (1987)

The polarization dependence of the gain/current relation and threshold current of quasi-index-guided laser diodes is analyzed for the case of λ=1.3 μm InGaAsP-InP ridge-waveguide lasers. Thereby it is shown that three different regimes for the stripe width and the lateral effective index discontinuity can be distinguished where one modal polarization (TE or TM) predominates. The significance of this finding on laser design and polarization control is discussed, and a comparison is performed on experimental results.
Power losses evaluation for modular multilevel converter with junction temperature feedback (2011)

This paper evaluates the converter power losses of the modular multilevel converter based HVDC systems (MMC-HVDC). A junction temperature feedback method is proposed in order to estimate the power losses more accurately. Based on the data provided by the manufacture, the characteristic of semiconductor device is acquired. Both the switching and conduction losses are calculated with the real-time voltage and current waveforms, which are derived from the detailed PSCAD/EMTDC model. Thermal circuit model is applied to estimate the average junction temperatures of the semiconductors. The converter valve losses with different heat sink temperatures are also investigated. Power losses evaluation results demonstrate that MMC topology has the lower valve losses than the 2-level or 3-level VSC topologies.
Bulk Micromachined Titanium Microneedles (2007)

Microneedle-based drug delivery has shown considerable promise for enabling painless transdermal and hypodermal delivery of conventional and novel therapies. However, this promise has yet to be fully realized due in large part to the limitations imposed by the micromechanical properties of the material systems being used. In this paper, we demonstrate titanium-based microneedle devices developed to address these limitations. Microneedle arrays with in-plane orientation are fabricated using recently developed high-aspect-ratio titanium bulk micromachining and multilayer lamination techniques. These devices include embedded microfluidic networks for the active delivery and/or extraction of fluids. Data from quantitative and qualitative characterization of the fluidic and mechanical performance of the devices are presented and shown to be in good agreement with finite-element simulations. The results demonstrate the potential of titanium micromachining for the fabrication of robust, reliable, and low-cost microneedle devices for drug delivery