gebhart/patrepeval huggingface dataset:
Rate-Transient Analysis of Tight Gas Condensate and Black Oil Wells Exhibiting Two-phase Flow (2016)

Quantitative Production Data Analysis (PDA) is a popular petroleum reservoir engineering technique that is employed to derive information about reservoir properties and well stimulation (hydraulic fractures). Rate-Transient Analysis (RTA), which is an advanced form of PDA, uses well flowing well pressures along with production rates to extract this information. Although mathematical models used for RTA are reasonably mature for conventional reservoirs, there are complexities associated with reservoir fluid storage and flow behavior that impede direct adaptation of these methods for low-permeability (tight), unconventional reservoirs. For example, wells producing from tight unconventional reservoirs may exhibit lengthy periods of transient flow, during which time multi-phase flow could occur. The primary objective of this thesis is to demonstrate that analytical RTA techniques may be adapted to quantitatively analyze and forecast wells producing from tight unconventional reservoirs exhibiting single− and multi-phase flow during the transient linear and boundary-dominated flow periods. In particular, multi-fractured horizontal wells (MFHWs) producing from tight gas condensate and oil reservoirs and exhibiting long-term transient linear flow are studied. Several commonly observed behaviors associated with MFHWs producing from tight reservoirs, such as constant gas-oil-ratios (GORs) during the transient linear flow, are explained analytically. Modified pseudovariables, critical for linearizing the diffusivity equation for describing multi-phase flow, are developed that allow the liquid-solution analogy to be applied to the transient linear and boundary-dominated flow versions of the diffusivity equation. Novel techniques for calculation of saturation pressure relationships, required for pseudovariable evaluation, are developed. Solutions that utilize modified pseudovariables are applied to both inverse and forward modeling of wells producing from these reservoir types. The accuracy of the new analytical approaches is demonstrated through comparison to numerical simulation, and practical utility through analysis of field cases. A secondary objective is to demonstrate the use of black oil simulation and surface fluid rate recombination techniques, combined with assisted history-matching techniques, to extract reservoir, hydraulic fracture and in-situ fluid compositions from MFHWs completed in tight gas condensate reservoirs. The analytical techniques developed in this thesis will be useful for petroleum engineers who employ analytical techniques in tight unconventional reservoir and hydraulic-fracture characterization.
Analysis of Protein Tyrosine Phosphorylation by Nanoelectrospray Ionization High-Resolution Tandem Mass Spectrometry and Tyrosine-Targeted Product Ion Scanning (2003)

A novel highly sensitive strategy is introduced for analysis of tyrosine phosphorylation in previously identified proteins channelling for this aim all analytical and sequence information available. Nanoelectrospray high-resolution MS/MS analysis is targeted to precalculated m/z values corresponding to phosphotyrosine-containing tryptic peptides. Identification of these peptides is supported by the occurrence of the phosphotyrosine immonium ion at m/z 216, neutral loss of 79.97/z (= loss of HPO3), and similarity of the fragmentation patterns of phosphotyrosine-containing peptides with their nonphosphorylated analogues. This tyrosine-targeted tandem mass spectrometry strategy is demonstrated for epidermal growth factor receptor showing that phosphotyrosine-containing tryptic peptides invisible in the survey spectrum can be safely identified.
InN-based anion selective sensors in aqueous solutions (2007)

We demonstrate that indium nitride (InN) can be used as ion selective electrode (ISE) for anion concentration measurements. The InN ISE reveals remarkable selectivity, response time, signal stability, and repeatability for chlorine and hydroxyl ions. The selective interaction of Lewis bases in solutions with the N-polarity InN epitaxial layer grown on silicon is confirmed by potentiometric responses. The Helmholtz potential of the InN ISE, generated at the InN/solution interface, satisfies the Nernst equation. The observation of anion attraction to the InN surface further demonstrates the existence of donor-type surface states on InN.
Fast switching ferroelectric side-chain liquid-crystalline polymer and copolymer (1991)

Abstract New ferroelectric side-chain liquid-crystalline polymers, a copolymer and a homopolymer, with siloxane backbone and a triaromatic mesogen as the side group have been synthesized. The materials exhibit a chiral smectic C phase over a large temperature range extending to room temperature. They possess high values of spontaneous polarization: 105 nC cm−2 for the homopolymer and 180 nC cm−2 for the copolymer. The electro-optic switching time in the chiral smectic C phase is extremely fast (150 μs). In the smectic A phase, an electroclinic effect with switching times less than 100 μs and with field induced tilt angles of 18° is observed.
Interferon Lambda: A New Sword in Cancer Immunotherapy (2011)

The discovery of the interferon-lambda (IFN-λ) family has considerably contributed to our understanding of the role of interferon not only in viral infections but also in cancer. IFN-λ proteins belong to the new type III IFN group. Type III IFN is structurally similar to type II IFN (IFN-γ) but functionally identical to type I IFN (IFN-α/β). However, in contrast to type I or type II IFNs, the response to type III IFN is highly cell-type specific. Only epithelial-like cells and to a lesser extent some immune cells respond to IFN-λ. This particular pattern of response is controlled by the differential expression of the IFN-λ receptor, which, in contrast to IFN-α, should result in limited side effects in patients. Recently, we and other groups have shown in several animal models a potent antitumor role of IFN-λ that will open a new challenging era for the current IFN therapy.
Facile CO<sub>2</sub> Electro-Reduction to Formate via Oxygen Bidentate Intermediate Stabilized by High-Index Planes of Bi Dendrite Catalyst (2017)

Electrochemical CO2 conversion to chemical products is a promising strategy for sustainable industrial development. However, the success of this approach requires an in-depth understanding of catalysis because it involves highly complex multistep reactions. Herein, we suggest a rational design of a hierarchical Bi dendrite catalyst for an efficient conversion of CO2 to formate. A high selectivity (∼89% at −0.74 VRHE) and, more importantly, a stable performance during long-term operation (∼12 h) were achieved with the Bi dendrite. Density functional theory (DFT) is used to investigate three possible reaction pathways in terms of surface intermediate, and the one via *OCOH surface intermediate is calculated to be the most energetically feasible. DFT calculations further elucidate the plane-dependent catalytic activity and conclude that the high-index planes developed on the Bi dendrite are responsible for the sustainable performance of Bi dendrite. We expect that our experimental and theoretical study will provide a fundamental guideline for the CO2-to-formate conversion pathway as well as design principles for enhancing the catalytic performance.
“Overshoot” of O<sub>2</sub>Is Required to Maintain Baseline Tissue Oxygenation at Locations Distal to Blood Vessels (2011)

In vivo imaging of cerebral tissue oxygenation is important in defining healthy physiology and pathological departures associated with cerebral disease. We used a recently developed two-photon microscopy method, based on a novel phosphorescent nanoprobe, to image tissue oxygenation in the rat primary sensory cortex in response to sensory stimulation. Our measurements showed that a stimulus-evoked increase in tissue pO₂ depended on the baseline pO₂ level. In particular, during sustained stimulation, the steady-state pO₂ at low-baseline locations remained at the baseline, despite large pO₂ increases elsewhere. In contrast to the steady state, where pO₂ never decreased below the baseline, transient decreases occurred during the "initial dip" and "poststimulus undershoot." These results suggest that the increase in blood oxygenation during the hemodynamic response, which has been perceived as a paradox, may serve to prevent a sustained oxygenation drop at tissue locations that are remote from the vascular feeding sources.
Microvascular Repair: Post‐Angiogenesis Vascular Dynamics (2012)

Vascular compromise and the accompanying perfusion deficits cause or complicate a large array of disease conditions and treatment failures. This has prompted the exploration of therapeutic strategies to repair or regenerate vasculatures, thereby establishing more competent microcirculatory beds. Growing evidence indicates that an increase in vessel numbers within a tissue does not necessarily promote an increase in tissue perfusion. Effective regeneration of a microcirculation entails the integration of new stable microvessel segments into the network via neovascularization. Beginning with angiogenesis, neovascularization entails an integrated series of vascular activities leading to the formation of a new mature microcirculation, and includes vascular guidance and inosculation, vessel maturation, pruning, AV specification, network patterning, structural adaptation, intussusception, and microvascular stabilization. While the generation of new vessel segments is necessary to expand a network, without the concomitant neovessel remodeling and adaptation processes intrinsic to microvascular network formation, these additional vessel segments give rise to a dysfunctional microcirculation. While many of the mechanisms regulating angiogenesis have been detailed, a thorough understanding of the mechanisms driving post-angiogenesis activities specific to neovascularization has yet to be fully realized, but is necessary to develop effective therapeutic strategies for repairing compromised microcirculations as a means to treat disease.
6-Deoxytetracyclines. V.<sup>1a</sup> 7,9-Disubstituted Products (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT6-Deoxytetracyclines. V.1a 7,9-Disubstituted ProductsJohn L. Spencer, Joseph J. Hlavka, Joseph Petisi, Helen M. Krazinski, and J. H. BootheCite this: J. Med. Chem. 1963, 6, 4, 405–407Publication Date (Print):July 1, 1963Publication History Published online1 May 2002Published inissue 1 July 1963https://pubs.acs.org/doi/10.1021/jm00340a014https://doi.org/10.1021/jm00340a014research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Metronidazole Vaginal Gel 1.3% in the Treatment of Bacterial Vaginosis (2014)

Metronidazole vaginal gel 1.3% applied once daily for 1, 3, or 5 days showed similar efficacy, safety, and tolerability as MVG 0.75% once daily for 5 days.
Visual Analytics for Automated Model Discovery. (2018)

A recent advancement in the machine learning community is the development of automated machine learning (autoML) systems, such as autoWeka or Google's Cloud AutoML, which automate the model selection and tuning process. However, while autoML tools give users access to arbitrarily complex models, they typically return those models with little context or explanation. Visual analytics can be helpful in giving a user of autoML insight into their data, and a more complete understanding of the models discovered by autoML, including differences between multiple models. In this work, we describe how visual analytics for automated model discovery differs from traditional visual analytics for machine learning. First, we propose an architecture based on an extension of existing visual analytics frameworks. Then we describe a prototype system Snowcat, developed according to the presented framework and architecture, that aids users in generating models for a diverse set of data and modeling tasks.
A Meta-Analysis of Tea Drinking and Risk of Parkinson's Disease (2012)

This meta-analysis showed that tea drinking can lower the risk of PD, while no apparent dose-response relationship was found. Further effort is needed to fully understand the mechanism underlying the beneficial effect of tea consumption in lowering PD risk.
Polar Coding Without Alphabet Extension for Asymmetric Models (2013)

This paper considers polar coding for asymmetric settings, that is, channel coding for asymmetric channels and lossy source coding for nonuniform sources and/or asymmetric distortion measures. The difficulty for asymmetric settings comes from the fact that the optimal symbol distributions of codewords are not always uniform. It is known that such nonuniform distributions can be realized by Gallager's scheme which maps multiple auxiliary symbols distributed uniformly to an actual symbol. However, the complexity of Gallager's scheme increases considerably for the case that the optimal distribution cannot be approximated by simple rational numbers. To overcome this problem for the asymmetric settings, a new polar coding scheme is proposed, which can attain the channel capacity without any alphabet extension by invoking results on polar coding for lossless compression. It is also shown that the proposed scheme achieves a better tradeoff between complexity and decoding error probability in many cases.
Hierarchical classification of glycoside hydrolases (2011)

This review deals with structural and functional features of glycoside hydrolases, a widespread group of enzymes present in almost all living organisms. Their catalytic domains are grouped into 120 amino acid sequence-based families in the international classification of the carbohydrate-active enzymes (CAZy database). At a higher hierarchical level some of these families are combined in 14 clans. Enzymes of the same clan have common evolutionary origin of their genes and share the most important functional characteristics such as composition of the active center, anomeric configuration of cleaved glycosidic bonds, and molecular mechanism of the catalyzed reaction (either inverting, or retaining). There are now extensive data in the literature concerning the relationship between glycoside hydrolase families belonging to different clans and/or included in none of them, as well as information on phylogenetic protein relationship within particular families. Summarizing these data allows us to propose a multilevel hierarchical classification of glycoside hydrolases and their homologs. It is shown that almost the whole variety of the enzyme catalytic domains can be brought into six main folds, large groups of proteins having the same three-dimensional structure and the supposed common evolutionary origin.
WAVELET BASED PALMPRINT RECOGNITION (2002)

Author name used in this publication: David Zhang
Diversity and phylogeny of gephyrin: Tissue-specific splice variants, gene structure, and sequence similarities to molybdenum cofactor-synthesizing and cytoskeleton-associated proteins (2000)

Gephyrin is essential for both the postsynaptic localization of inhibitory neurotransmitter receptors in the central nervous system and the biosynthesis of the molybdenum cofactor (Moco) in different peripheral organs. Several alternatively spliced gephyrin transcripts have been identified in rat brain that differ in their 5' coding regions. Here, we describe gephyrin splice variants that are differentially expressed in non-neuronal tissues and different regions of the adult mouse brain. Analysis of the murine gephyrin gene indicates a highly mosaic organization, with eight of its 29 exons corresponding to the alternatively spliced regions identified by cDNA sequencing. The N- and C-terminal domains of gephyrin encoded by exons 3-7 and 16-29, respectively, display sequence similarities to bacterial, invertebrate, and plant proteins involved in Moco biosynthesis, whereas the central exons 8, 13, and 14 encode motifs that may mediate oligomerization and tubulin binding. Our data are consistent with gephyrin having evolved from a Moco biosynthetic protein by insertion of protein interaction sequences.
Wideband co-site interference cancellation based on hybrid electrical and optical techniques (2014)

A wideband co-site co-channel interference cancellation system (ICS), based on hybrid electrical and optical techniques, is proposed and is experimentally demonstrated. The demonstrated cancellation system subtracts the in-band wideband interfering signal from the received signal, such that the weak signal of interest (SOI) can be recovered. Our system utilizes a broadband radio frequency (RF) Balun transformer to invert the phase of the interfering signal, while electro-absorption modulated lasers are used for converting the RF signals into the optical domain to enable fine adjustment with the hybrid ICS. We experimentally achieve 45 dB of cancellation over a 220 MHz bandwidth, and over 57 dB of cancellation for a 10 MHz bandwidth, at a center frequency of 900 MHz. The proposed system also experimentally shows good cancellation (30 dB) over an enormously wide bandwidth of 5.5 GHz. To the best of our knowledge, this is the first demonstration of such a wide bandwidth cancellation with good cancellation depth. This property is extremely useful when there are multiple interference signals at various frequency bands. The proposed hybrid ICS has a spurious-free dynamic range of 93.2 dBm/Hz(2/3). Moreover, a 10 Gb/s SOI is recovered from a strong interfering signal, sweeping over 3 GHz bandwidth. A widely open eye diagram, as well as error-free bit-error rate measurements, is experimentally achieved, with the use of the hybrid ICS. The approach also works well for various frequency bands that are within the bandwidth of the Balun transformer and electro-absorption modulated lasers.
Design of a plug-and-play pulse oximeter (2002)

Presents the design of a plug-and-play pulse oximeter that communicates with a LabVIEW virtual instrument. The sensor module samples plethysmographic data and sends them to a personal computer via an RS-232 serial link. The system configuration is described, and the response of the system is discussed when either the computer, sensor, or RS-232 connection breaks down. The oximeter is suitable for home use and can reliably collect pulsatile data from multiple body locations (e.g. finger, forehead, palm, etc.).
Assessment of the Phototoxic Potential of Compounds and Finished Topical Products Using a Human Reconstructed Epidermis (2001)

The goal of this study was to design a model system for the assessment of phototoxic potential using a human reconstructed epidermis (HRE, SkinEthic Laboratories, Nice, France), by testing some representative phototoxic (P) and non-phototoxic (NP) compounds and finished topical products. The tissue response to 24-h application of 5-5000 microg/mL of the test agents in the presence and absence of UVA light was analyzed in terms of viability (Lactate Dehydrogenase release), pro-inflammatory activity (IL-8 release and mRNA expression) and morphology (histopathology). 8-Methoxypsoralen (P) and promethazin (P), but not sodium lauryl sulfate (NP) produced cytotoxicity concentration-response curves significantly different between irradiated and nonirradiated tissues. Only irradiated tissues showed morphological damage. Application of tetracyclin (P) in the culture medium, but not topically, induced similar signs of phototoxicity. 6-Methylcoumarine (weak P) was not cytotoxic, yet it increased IL-8 release and mRNA expression only following UVA irradiation. PUVA therapy creams containing 1% 8-Methoxy-psoralen (P) or coal tar (P) decreased viability and induced histologic damage in UVA-exposed tissues. In conclusion, the phototoxic potential of the tested agents was correctly predicted by using a tiered strategy that involves determining cytotoxicity, production of IL-8, and morphological damage following exposure of the HRE to the compounds and UVA light.
Network management considerations for interworking ATM networks with non-ATM services (1996)

Rapid progress has been made on standards and implementation agreements for interworking ATM networks with frame relay, DS1/DS3 circuits, and SMDS. This article examines ATM network management issues in these interworking environments, with an emphasis on how each interworking environment has unique requirements for network management.
The culture and skills challenges associated with servitization : a South African perspective (2010)

The boundaries between the manufacturing of products and the provision of service are increasingly breaking down and becoming blurred as institutions implement servitization strategies. It is suggested that there are,\nhowever, two very pertinent hurdles that need to be overcome in implementing such a strategy, namely culture transformation and the development of a new set of skills required for dealing with service provision. These challenges confronting management were analysed on the basis of a multidisciplinary literature research and the findings emanating from the study are briefly dealt with in this paper. A particularly\nimportant finding relates to the fact that in addition to manufacturing technological skills, a far wider range of multidisciplinary skills are required and these within a South African context are not always readily available. In addition it was found that traditional management paradigms of culture transformation may not be all that\neffect in dealing with a very complex servitization contextual setting. These findings and the insights gained from the research study could be of value to executives and managers of South African manufacturing institutions who are considering implementing a servitization strategy.
MEMS RF devices for antenna applications (2002)

In this paper, we reviewed the RF MEMS research efforts at the University of Hawaii. The efforts, which are fused with MEMS technologies and antenna theories, can be divided into two areas: planar reconfigurable transceivers and phased arrays using MEMS devices. For the planar transceivers, the interest is in demonstration of new MEMS RF devices with a focus on integration issues (architectures and fabrication) to establish building blocks for reconfigurable transceivers that have beam forming and tuning functionality. For phased-array applications, we demonstrated the system architectures of quasi-optical beam-forming apertures and phased arrays using MEMS RF switches and photonic bandgap ground planes instead of phase shifters.
Plasma extracellular nanovesicle (exosome)‐derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure (2018)

Consistent strong concordance was observed between exosome-derived CYP3A4 biomarkers and midazolam CL/F. The significance of these results is that CYP3A4 is the drug-metabolizing enzyme of greatest clinical importance and variability in CYP3A4 activity is poorly described by existing precision dosing strategies.