gebhart/patrepeval huggingface dataset:
Server networks: software integration tools for CIM (2003)

Graphical software-development mechanisms are presented that produce server networks, which are flexible, modular CIM (computer-aided manufacturing) software systems. The Server Network Generator (SNG) is an interactive expert system used to graphically configure a network, while automatically enforcing network integrity rules, and to remotely develop and maintain its distributed software. Graphical programming is used with the data-driven control-flow methodology (DDCF) and an interprocess communication mechanism called share variables to implement flexible server communication. A prototype server network, including an SNG, a dispatcher, and servers, has been built and is in use.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Versatile Syntheses of Alkynyl- and Substituted Alkynylcyclopropanes: 2-Alkoxyethynylcyclopropanes for the Anellation of Bicyclo[3.3.0]octane Fragments (1993)

Enol ethers 1a-f are brominated at - 78° C and the resulting alkyl 1,2-dibromoethyl ethers are regioselectively coupled with propargyl-magnesium bromide to give 4-alkoxy-5-bromo-1-pentynes 2a-f, which are protected at the acetylenic terminus with a trimethylsilyl group. These 4-alkoxy-5-bromo-1-trimethylsilyl-1-pentynes 3a-f readily cyclize by γ-elimination to give trimethylsilyl protected 2-alkoxyethynylcyclopropanes 4a-f in excellent overall yields. Under appropriate conditions (E)-diastereomers (E)-4a-f can be prepared selectively. The diastereoselectivity of the bromine addition onto enantiomerically pure chiral enol ethers 1e and 1f, however, is 64% (for 2f) at best. 2-Alkoxy-1-trimethylsilylethynyl-cyclopropanes (E/Z)-4 can be deprotonated with LDA or butyllithium to give configurationally stable 1-lithio derivatives (E)-6, which are trapped by reactive electrophiles (protons, carbonyl compounds, tosyl halides) with retention of configuration on the three-membered ring. 2-Alkoxy-1-ethynylcyclopropanes 5 can be used to anellate a bicyclo[3.3.0]octane fragment onto a cycloalkene in a domino-type reaction sequence, as demonstrated by the Pauson-Khand cycloaddition of (E)-5c to norbornene (14) as well as deltacyclene (20), and subsequent interconversion to the tetracyclic and hexacyclic compounds anti/syn-19 and anti/syn-25/27 with a reasonable degree of diastereoselectivity.
Extracellular Matrix Proteins in Hemostasis and Thrombosis (2011)

The adhesion and aggregation of platelets during hemostasis and thrombosis represents one of the best-understood examples of cell-matrix adhesion. Platelets are exposed to a wide variety of extracellular matrix (ECM) proteins once blood vessels are damaged and basement membranes and interstitial ECM are exposed. Platelet adhesion to these ECM proteins involves ECM receptors familiar in other contexts, such as integrins. The major platelet-specific integrin, αIIbβ3, is the best-understood ECM receptor and exhibits the most tightly regulated switch between inactive and active states. Once activated, αIIbβ3 binds many different ECM proteins, including fibrinogen, its major ligand. In addition to αIIbβ3, there are other integrins expressed at lower levels on platelets and responsible for adhesion to additional ECM proteins. There are also some important nonintegrin ECM receptors, GPIb-V-IX and GPVI, which are specific to platelets. These receptors play major roles in platelet adhesion and in the activation of the integrins and of other platelet responses, such as cytoskeletal organization and exocytosis of additional ECM ligands and autoactivators of the platelets.
Integrated optical transmitter and receiver (1983)

Abstract : This document reports the results of a one-year program, based on a technical proposal submitted to and accepted by DARPA, to develop a technology for realizing a GaAlAs/GaAs monolithic integrated optoelectronic transmitter for high-speed fiber-optic communications applications. The primary objectives were to: (1) determine a suitable approach for integrating optical and electronic devices in terms of compatible device processing and fabrication, (2) design a simplified high-speed transmitter based on the integration approach which will serve as a building block for future more sophisticated designs, (3) develop the transmitter materials technology, (4) develop the transmitter device components, and (5) fabricate and demonstrate the integrated transmitter. At the end of the programs, all of the objectives were realized except for the demonstration of a functional transmitter. A selective epitaxial growth technique using a dielectric mask was developed for process/fabrication compatibility of the laser with planar ion-implanted GaAs electronic devices with 1 micron-type geometries. Based on this integration approach, a nominal 1-4 Gb/s transmitter set utilizing standard cleaved mirror lasers and field-effect transistor (FET)/Gunn logic drivers was designed, process/fabrication steps defined, and a fabrication mask set generated.
A Low-Complexity and High-Quality Image Compression Method for Digital Cameras (2006)

This letter proposes a new near-lossless image compression method with only one line buffer cost for a digital camera with Bayer format image. For such format data, it can provide a low average compression rate (4.24bits/pixel) with high-image quality (larger than 46.37dB where the error of every pixel is less than two). The experimental results show that the near-lossless compression method has better performance than JPEG-LS (lossless) with δ = 2 for a Bayer format image.
Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Na&#239;ve-like State with Improved Multilineage Differentiation Potency (2018)

Naïve human pluripotent stem cells (N-hPSC) with improved functionality may have a wide impact in regenerative medicine. The goal of this protocol is to efficiently revert lineage-primed, conventional human pluripotent stem cells (hPSC) maintained on either feeder-free or feeder-dependent conditions to a naïve-like pluripotency with improved functionality. This chemical naïve reversion method employs the classical leukemia inhibitory factor (LIF), GSK3β, and MEK/ERK inhibition cocktail (LIF-2i), supplemented with only a tankyrase inhibitor XAV939 (LIF-3i). LIF-3i reverts conventional hPSC to a stable pluripotent state adopting biochemical, transcriptional, and epigenetic features of the human pre-implantation epiblast. This LIF-3i method requires minimal cell culture manipulation and is highly reproducible in a broad repertoire of human embryonic stem cell (hESC) and transgene-free human induced pluripotent stem cell (hiPSC) lines. The LIF-3i method does not require a re-priming step prior to the differentiation; N-hPSC can be differentiated directly with extremely high efficiencies and maintain karyotypic and epigenomic stabilities (including at imprinted loci). To increase the universality of the method, conventional hPSC are first cultured in the LIF-3i cocktail supplemented with two additional small molecules that potentiate protein kinase A (forskolin) and sonic hedgehog (sHH) (purmorphamine) signaling (LIF-5i). This brief LIF-5i adaptation step significantly enhances the initial clonal expansion of conventional hPSC and permits them to be subsequently naïve-reverted with LIF-3i alone in bulk quantities, thus obviating the need for picking/subcloning rare N-hPSC colonies later. LIF-5i-stabilized hPSCs are subsequently maintained in LIF-3i alone without the need of anti-apoptotic molecules. Most importantly, LIF-3i reversion markedly improves the functional pluripotency of a broad repertoire of conventional hPSC by decreasing their lineage-primed gene expression and erasing the interline variability of directed differentiation commonly observed amongst independent hPSC lines. Representative characterizations of LIF-3i-reverted N-hPSC are provided, and experimental strategies for functional comparisons of isogenic hPSC in lineage-primed vs. naïve-like states are outlined.
Clinical Decision Support for In-Hospital AKI (2017)

AKI carries a significant mortality and morbidity risk. Use of a clinical decision support system (CDSS) might improve outcomes. We conducted a multicenter, sequential period analysis of 528,108 patients without ESRD before admission, from October of 2012 to September of 2015, to determine whether use of a CDSS reduces hospital length of stay and in-hospital mortality for patients with AKI. We compared patients treated 12 months before (181,696) and 24 months after (346,412) implementation of the CDSS. Coprimary outcomes were hospital mortality and length of stay adjusted by demographics and comorbidities. AKI was diagnosed in 64,512 patients (12.2%). Crude mortality rate fell from 10.2% before to 9.4% after CDSS implementation (odds ratio, 0.91; 95% confidence interval [95% CI], 0.86 to 0.96; <i>P</i>=0.001) for patients with AKI but did not change in patients without AKI (from 1.5% to 1.4%). Mean hospital duration decreased from 9.3 to 9.0 days (<i>P</i><0.001) for patients with AKI, with no change for patients without AKI. In multivariate mixed-effects models, the adjusted odds ratio (95% CI) was 0.76 (0.70 to 0.83) for mortality and 0.66 (0.61 to 0.72) for dialysis (<i>P</i><0.001). Change in adjusted hospital length of stay was also significant (incidence rate ratio, 0.91; 95% CI, 0.89 to 0.92), decreasing from 7.2 to 6.0 days for patients with AKI. Results were robust to sensitivity analyses and were sustained for the duration of follow-up. Hence, implementation of a CDSS for AKI resulted in a small but sustained decrease in hospital mortality, dialysis use, and length of stay.
Genetic Control of Flagellation in <i>Bacillus subtilis</i> (1967)

Flagellation in Bacillus subtilis was shown to involve at least three loci: a gene H controlling the specificity of the flagellar antigen; a gene fla controlling the presence or absence of flagella; and a gene mot controlling the function of the flagella. The loci were shown to be nonallelic and unlinked in transformation tests. Strains W 23 and SB 108-b, a derivative of strain 168, were shown to differ in their major flagellar antigen.
Home automation using IoT and a chatbot using natural language processing (2017)

Home automation - controlling the fans, lights and other electrical appliances in a house using Internet of things is widely preferred in recent days. In this paper, we propose a web application using which the fans, lights and other electrical appliances can be controlled over the Internet. The important features of the web application is that firstly, we have a chatbot algorithm such that the user can text information to control the functioning of the electrical appliances at home. The messages sent using the chatbot is processed using Natural Language processing techniques. Secondly, any device connected to the local area network of the house can control the devices and other appliances in the house. Thirdly, the web application used to enable home automation also has a security feature that only enables certain users to access the application. And finally, it also has a functionality of sending an email alert when intruder is detected using motion sensors.
A survey on cloud interoperability (2013)

Cloud computing is a new computing paradigm that allows users with different computing demands to access a shared pool of configurable computing resources (e.g., servers, network, storage, database, applications and services). Many commercial cloud providers have emerged in the past 6-7 years, and each typically provides its own cloud infrastructure, APIs and application description formats to access the cloud resources, as well as support for service level agreements (SLAs). Such vendor lock-in has seriously limited the flexibility that cloud end users would like to process, when it comes to deploy applications over different infrastructures in different geographic locations, or to migrate a service from one provider's cloud to another. To enable seamless sharing of resources from a pool of cloud providers, efforts have emerged recently to facilitate cloud interoperability, i.e., the ability for multiple cloud providers to work together, from both the industry and academia. In this article, we conduct a comprehensive survey on the state-of-the-art efforts, with a focus on interoperability among different IaaS (infrastructure as a service) cloud platforms. We investigate the existing studies on taxonomies and standardization of cloud interoperability, as well as practical cloud technologies from both the cloud provider's and user's perspectives to enable interoperation. We pose issues and challenges to advance the topic area, and hope to pave a way for the forthcoming research.
Urokinase Plasminogen Activator Impairs SNP and PGE <sub>2</sub> Cerebrovasodilation after Brain Injury through Activation of LRP and ERK MAPK (2008)

Pial artery dilation in response to prostaglandin (PG)E(2) and the nitric oxide (NO) releaser sodium nitroprusside (SNP) are blunted after fluid percussion brain injury (FPI), whereas responses to papaverine are unchanged. Urokinase plasminogen activator (uPA) and ERK mitogen-activated protein kinase (MAPK) are upregulated and contribute to the impairment of cerebrohemodynamics seen after FPI. PA vascular activity is mediated through the low-density lipoprotein receptor (LRP). Therefore, we investigated the role of uPA, LRP, and ERK MAPK in the impaired cerebrovasodilation response to PGE(2) and SNP after FPI. Lateral FPI (2 atm) was induced in anesthetized piglets equipped with a closed cranial window. Cerebrospinal fluid (CSF) ERK MAPK was quantified by enzyme-linked immunosorbent assay (ELISA). Pretreatment with soluble uPA receptor (suPAR), which antagonizes the vascular action of uPA, blunted the impairment of SNP and PGE(2)-mediated dilation seen after FPI. Pretreatment with the LRP antagonist RAP, a monoclonal antibody against LRP (Mab ag LRP) and the ERK MAPK antagonist, U 0126, all provided similar protection, whereas control immunoglobulin G (IgG) had no effect. Responses to papaverine were unchanged after FPI. Upregulation of ERK MAPK phosphorylation in CSF after FPI was blunted in animals pretreated with suPAR, RAP, MAb ag LRP, or U 0126, whereas control IgG had no effect. These data indicate that uPA contributes to the impairment of SNP and PGE(2)-mediated cerebrovasodilation seen after brain injury through activation of LRP and ERK MAPK.
Resource Allocation Optimization for Delay-Sensitive Traffic in Fronthaul Constrained Cloud Radio Access Networks (2014)

The cloud radio access network (C-RAN) provides high spectral and energy efficiency performances, low expenditures and intelligent centralized system structures to operators, which has attracted intense interests in both academia and industry. In this paper, a hybrid coordinated multi-point transmission (H-CoMP) scheme is designed for the downlink transmission in C-RANs, which fulfills the flexible tradeoff between cooperation gain and fronthaul consumption. The queue-aware power and rate allocation with constraints of average fronthaul consumption for the delay-sensitive traffic are formulated as an infinite horizon constrained partially observed Markov decision process (POMDP), which takes both the urgent queue state information (QSI) and the imperfect channel state information at transmitters (CSIT) into account. To deal with the curse of dimensionality involved with the equivalent Bellman equation, the linear approximation of post-decision value functions is utilized. A stochastic gradient algorithm is presented to allocate the queue-aware power and transmission rate with H-CoMP, which is robust against unpredicted traffic arrivals and uncertainties caused by the imperfect CSIT. Furthermore, to substantially reduce the computing complexity, an online learning algorithm is proposed to estimate the per-queue post-decision value functions and update the Lagrange multipliers. The simulation results demonstrate performance gains of the proposed stochastic gradient algorithms, and confirm the asymptotical convergence of the proposed online learning algorithm.
Identification and egg hatching activity of monohydroxy fatty acid eicosanoids in the barnacle <i>Balanus balanoides</i> (1992)

Monohydroxy fatty acids (MHFAs) were isolated from homogenates of the barnacle Balanus balanoides and identified by gas chromatography-mass spectrometry (GC-MS) as 14- and 17-hydroxy docosahexaenoic acids, 8-, 11-, 12-, 15- and 18-hydroxy eicosapentaenoic acids, 13- and 16-hydroxyoctadecatrienoic acids and 9-, 13- and 15-hydroxyoctadecadienoic acids. Each monohydroxy fatty acid was tested for egg hatching activity in a bioassay using Elminius modestus egg masses, but 8-hydroxy-5, 9, 11, 14, 17-eicosapentaenoic acid (8-HEPE) was the only MHFA with barnacle egg hatching activity. Studies on the egg hatching activity of MHFAs prepared from the oxidation of polyunsaturated fatty acids showed that activity was confined to the 8-hydroxy isomer of eicosapentaenoic acid and arachidonic acid, and that unsaturation at C5 and C14, but not C17, was essential for activity. In addition, the 8(R) conformation is necessary for activity, as 8(R)-HEPE caused egg hatching at 10(-7) M whereas the enantiomer 8(S)-HEPE was inactive.
A high energy X-ray computed tomography using silicon semiconductor detectors (2002)

Second- and third-generation high energy industrial X-ray computed tomography systems using silicon semiconductor detectors were developed. Both systems consist of a high energy X-ray source using an electron linear accelerator with the maximum energy of 6 MeV and an array detector unit using silicon semiconductor detectors. This unit also includes a collimator with slits 0.2 mm wide and 1.4 mm high, located in front of the detectors. To increase sensitivity, detector elements were placed parallel to the X-ray beams, The third-generation system had 512 detector elements arrayed with 1.3 mm pitch. To reduce detector pitch, each detector chip was mounted on a tungsten base plate using a thin film circuit board. The plate acts as shield to absorb incoming scattered X-rays and secondary electrons generated at neighbor detectors. Performance tests were carried out in the second- and third-generation systems. The spatial resolution of 0.30 mm was confirmed for an iron test piece of 70 mm diameter using the second-generation system. The scans for a slice were completed within less than 10 seconds in the third-generation system.
X-ray Studies on the Structures of Solid Solutions NaCl-CaCl<sub>2</sub> I. Main Results and General Considerations (1954)

Stationary X-ray diffraction patterns from transparent single crystals of solid solutions of NaCl dissolved with a few per cent of CaCl 2 show a number of diffuse spots. Their displacements with the change of the direction of incident X-rays reveal the existence of several kinds of rods in reciprocal space. Among them, the rods running along <111> and <310> rows are most remarkable. The appearance of these rods are considered as the result of the formation of thin plate-like precipitates in the matrix because of the homogeneous solid solutions being unstable at room temperatures. The precipitates may be the places where Ca ++ ions replacing Na + ions, and vacancies of Na + sites, are locally concentrated. It was shown, by a general consideration, that the plate-like precipitate responsible for <111> or <310> rods is likely composed of an assembly of anti-phase, domains of super structures.
“Stress” and its Implications in Poultry Production (1959)

(1959). “Stress” and its Implications in Poultry Production. World's Poultry Science Journal: Vol. 15, No. 3, pp. 255-263.
<i>N</i>-Heterocyclic Carbene-Catalyzed Generation of Homoenolates:  γ-Butyrolactones by Direct Annulations of Enals and Aldehydes (2004)

N-Heterocyclic carbenes, prepared in situ from diarylimidazolium salts, serve as highly effective catalysts for the generation of reactive homoenolates from alpha,beta-unsaturated aldehydes. The catalyst-bound homoenolate reacts with electrophilic aldehydes leading, via the key intermediacy of an activated carboxylate, to gamma-butyrolactones in good yields and stereoselectivities. Importantly, this process demonstrates an unprecedented reaction mode for the generation of nucleophilic carbanions with a multifunctional organocatalyst under exceptionally mild and convenient reaction conditions.
AlGaN-based ultraviolet light detectors with integrated optical filters (2000)

AlGaN-based ultraviolet light detectors with high responsivities in a narrow range of photon energy (≈0.3 eV) were grown by plasma induced molecular beam epitaxy on sapphire substrates. A thin Al0.4Ga0.6N film acting as an optical filter blocking high energy light was separated by an insulating AlGaN barrier from a third light sensitive Al0.3Ga0.7N layer. By optimizing the alloy compositions in the heterostructure and thickness of the filter layer, a peak responsivity of up to 35 A/W was achieved over a narrow range of wavelength with a peak position at 305 nm. The rejection of visible light response with respect to the peak responsivity was 5 orders of magnitude for a photoconductor device with a filter thickness of 1.4 μm. Decay times of the photoresponse after excimer laser exposure were determined to be between 40 and 330 ns.
Immunotherapy in Bladder Cancer with Keyhole-Limpet Hemocyanin: A Randomized Study (1988)

A randomized, controlled study was begun in 1982 on the effect of keyhole-limpet hemocyanin and mitomycin C in the prevention of recurrent superficial bladder cancer (stages pTa to pT1, grades 0 to 3) in 44 patients. All tumors were resected and all patients were presumed to be free of tumor at initiation of the prophylactic instillations. Before the bladder instillation program was begun all patients in the keyhole-limpet hemocyanin group Ia were immunized with 1 mg. keyhole-limpet hemocyanin intracutaneously and then monthly bladder instillations of 10 mg. were given. The control group Ib received 20 mg. mitomycin C monthly. Of the 21 patients in the keyhole-limpet hemocyanin group Ia (mean followup 20.7 months) 3 (14.2 per cent) had recurrences, compared to 9 of 23 (39.1 per cent) in the mitomycin C group Ib (mean followup 18.3 months). The over-all preventive effect was significantly better (p less than 0.05, chi-square) in keyhole-limpet hemocyanin-treated patients than in those given mitomycin C. In 1984 a new single drug study (group II) was started with keyhole-limpet hemocyanin alone, administered as in group Ia. Of 81 patients in group II (nonrandomized, mean followup 22.8 months) 17 (20.9 per cent) had recurrences. Of the patients given keyhole-limpet hemocyanin 20 of 21 (95.2 per cent) in group Ia and 70 of 81 (86.4 per cent) in group II had complete and partial prevention (downgrading), compared to 16 of 23 (69.5 per cent) in group Ib. Our study was established to analyze the effect of a new method of immunotherapy; no adverse local or systemic side effects were noted.