gebhart/patrepeval huggingface dataset:
Apoptin Nucleocytoplasmic Shuttling Is Required for Cell Type-Specific Localization, Apoptosis, and Recruitment of the Anaphase-Promoting Complex/Cyclosome to PML Bodies (2006)

The chicken anemia virus protein Apoptin selectively induces apoptosis in transformed cells while leaving normal cells intact. This selectivity is thought to be largely due to cell type-specific localization: Apoptin is cytoplasmic in primary cells and nuclear in transformed cells. The basis of Apoptin cell type-specific localization and activity remains to be determined. Here we show that Apoptin is a nucleocytoplasmic shuttling protein whose localization is mediated by an N-terminal nuclear export signal (NES) and a C-terminal nuclear localization signal (NLS). Both signals are required for cell type-specific localization, since Apoptin fragments containing either the NES or the NLS fail to differentially localize in transformed and primary cells. Significantly, cell type-specific localization can be conferred in trans by coexpression of the two separate fragments, which interact through an Apoptin multimerization domain. We have previously shown that Apoptin interacts with the APC1 subunit of the anaphase-promoting complex/cyclosome (APC/C), resulting in G(2)/M cell cycle arrest and apoptosis in transformed cells. We found that the nucleocytoplasmic shuttling activity is critical for efficient APC1 association and induction of apoptosis in transformed cells. Interestingly, both Apoptin multimerization and APC1 interaction are mediated by domains that overlap with the NES and NLS sequences, respectively. Apoptin expression in transformed cells induces the formation of PML nuclear bodies and recruits APC/C to these subnuclear structures. Our results reveal a mechanism for the selective killing of transformed cells by Apoptin.
Principal Component Analysis as a Tool for Analyzing Beat-to-Beat Changes in ECG Features: Application to ECG-Derived Respiration (2009)

An algorithm for analyzing changes in ECG morphology based on principal component analysis (PCA) is presented and applied to the derivation of surrogate respiratory signals from single-lead ECGs. The respiratory-induced variability of ECG features, P waves, QRS complexes, and T waves are described by the PCA. We assessed which ECG features and which principal components yielded the best surrogate for the respiratory signal. Twenty subjects performed controlled breathing for 180 s at 4, 6, 8, 10, 12, and 14 breaths per minute and normal breathing. ECG and breathing signals were recorded. Respiration was derived from the ECG by three algorithms: the PCA-based algorithm and two established algorithms, based on RR intervals and QRS amplitudes. ECG-derived respiration was compared to the recorded breathing signal by magnitude squared coherence and cross-correlation. The top ranking algorithm for both coherence and correlation was the PCA algorithm applied to QRS complexes. Coherence and correlation were significantly larger for this algorithm than the RR algorithm(p < 0.05 and p < 0.0001, respectively) but were not significantly different from the amplitude algorithm. PCA provides a novel algorithm for analysis of both respiratory and nonrespiratory related beat-to-beat changes in different ECG features.
The use of state and general hospitals for inpatient psychiatric care. (1998)

These results demonstrate that probabilistic methodologies can significantly enhance the value of existing databases for epidemiological research.
Multimedia based PC assembly learning tool (2002)

This paper describes HALT (Hardware Assembly Learning Tool), a learning tool, that embodies the strengths of both multimedia and artificial intelligence. The system supports exploratory type of learning and provides an adaptive environment that allows the user to navigate the hypertext system effectively. It involves static display of bitmaps, the integration of hypertext, sound and video by means of multimedia techniques. HALT demonstrates the effectiveness of multimedia in the implementation of a software learning tool to guide computer users to assemble the various computer components into a complete computer set by themselves and to help them to troubleshoot should problems arise.
Role of the hydrogen plasma treatment in layer-by-layer deposition of microcrystalline silicon (1997)

We have investigated the role of hydrogen in hydrogenated microcrystalline silicon (μc-Si:H) formation using hydrogen plasma treatments, in particular examining the possibility of subsurface reaction due to permeating hydrogen atoms, which leads to the crystallization of hydrogenated amorphous silicon (a-Si:H). It is demonstrated that the hydrogen plasma treatment of a-Si:H film on the anode using a cathode covered by a-Si:H film, which is inevitably coated during the deposition period, gives rise to the deposition of μc-Si:H over the a-Si:H layer, i.e., chemical transport takes place. It is also found that the pure hydrogen plasma treatment using a clean cathode induces only etching of the a-Si:H layer. These results imply that the present hydrogen plasma condition does not cause crystallization of a-Si:H but only etching, and that careful experimentation is required to determine the real subsurface reaction due to atomic hydrogen.
On the realtime satellite image compression of X-sat (2004)

The transmission of image data acquired by remote sensing missions based on spaceborne platforms is a major bottleneck. It results from limited power on-board, the huge volume of the data, and the number of accessible ground receiving stations. In particular these arguments hold true for small satellites that face additional design constraints in terms of size, mass and cost. To relax the downlink restriction image compression has to be applied. This paper analyses the architecture and requirements for the minisatellite X-Sat and sets them in relation with selected compression algorithms. Due to the realtime nature of the mission, i.e. simultaneous imaging and downlinking, only hardware-based solutions are considered. The investigation addresses the issues of achievable compression ratios and guaranteeing lossless compression.
Legacy Software Modernization (2006)

Software modernization converts legacy systems into component-based systems. The process involves program understanding, business rules extraction, and software transformation. In this paper, we will present a semi-automated program slicing technique for business rules extraction from legacy code and convert the reusable code into a component conforming to the protocols of a component interconnection model. The component interconnection model was developed to standardize the development of the components so they can communicate with each other seamlessly in a heterogeneous computing environment. We adopted CORBA as an underlying communicating infrastructure in the model.
A Dual−Ion Battery Cathode via Oxidative Insertion of Anions in a Metal–Organic Framework (2015)

A redox-active metal-organic framework, Fe2(dobpdc) (dobpdc(4-) = 4,4'-dioxidobiphenyl-3,3'-dicarboxylate), is shown to undergo a topotactic oxidative insertion reaction with a variety of weakly coordinating anions, including BF4(-) and PF6(-). The reaction results in just a minor lattice contraction, and a broad intervalence charge-transfer band emerges, indicative of charge mobility. Although both metal- and ligand-based oxidations can be accessed, only the former were found to be fully reversible and, importantly, proceed stoichiometrically under both chemical and electrochemical conditions. Electrochemical measurements probing the effects of nanoconfinement on the insertion reaction revealed strong anion size and solvent dependences. Significantly, the anion insertion behavior of Fe2(dobpdc) enabled its use in the construction of a dual-ion battery prototype incorporating a sodium anode. As a cathode, the material displays a particularly high initial reduction potential and is further stable for at least 50 charge/discharge cycles, exhibiting a maximum specific energy of 316 Wh/kg.
Trapping of Human Hemoglobin by Haptoglobin: Molecular Mechanisms and Clinical Applications (2012)

A detailed analysis of the influence of Hp glycosylation will be instrumental to generate a deeper understanding of its biological function. Several pathological conditions also modify the glycan compositions allowing Hp to be potentially used as a marker protein for these disorders.
Reflection of a Gaussian ultrasonic beam from a liquid-solid interface (1974)

A Gaussian distribution of amplitudes in an ultrasonic beam reflected from liquid-solid interfaces is used in the reexamination of the concept of “beam displacement” which occurs at the angle of excitation of surface waves on the interface. Experimental results show that the energy of the reflected beam is redistributed into two or more beams at (or near) this angle. The theory of Brekhovskikh has been extended to include both a Gaussian input beam and the second derivative of the phase shift upon reflection. Reasonable agreement is obtained between theory and experiment for water-aluminum and water-brass interfaces. For water-beryllium and water-stainless steel the agreement is fair.
Two PC 12 Pheochromocytoma Lines Sealed in Hollow Fiber-Based Capsules Tonically Release L-Dopa In Vitro (1993)

Two PC12 cell-derived lines have been studied following encapsulation into polymer-based hollow fibers with respect to secreted catecholamines and their metabolites. Cellular encapsulation provides a chronic microperfusion environment within which basally secreted PC12 products can be readily measured. Encapsulated PC12 cells grown and held under the conditions specified in this report basally release amounts exceeding their total cellular stores of the dopamine precursor L-DOPA and the electrochemically active dopamine metabolites DOPAC and HVA during 45-min static incubations. Under these same conditions, these cells release less than 0.1% of their total cellular store of dopamine. Depolarizing incubations enhance dopamine secretion eightyfold and enhance secretion of L-DOPA, HVA, and DOPAC about twofold. The relative composition of products basally secreted differs between PC12-derived cell lines, and an inverse relationship exists between basal release of L-DOPA and total cellular store of dopamine. These results further indicate that selected PC12 cell lines are potentially a source of both dopamine and L-DOPA in therapeutic cellular replacement applications.
Structure and Adsorption of 3-Acryloxypropyltrimethoxysilane (1999)

The adsorption of 3-acryloxypropyltrimethoxysilane (APMS) onto silica and structures formed from the adsorption were studied using gravimetric analysis and NMR. APMS molecules were hydrolyzed at room temperature and then condensed at 110 °C with other APMS molecules or on a silica surface. After heat treatment at 110 °C, the alkyl groups of APMS from the bulk species or the immobilized species on the silica surface were investigated using 13C cross-polarization, magic-angle spinning (CP-MAS) NMR. 29Si MAS and CP-MAS NMR techniques showed that most of the APMS silanol groups were condensed to 27% T2 and 73% T3 species during heat treatment at 110 °C. The condensed APMS was then pyrolized at 600 °C. Most of the APMS alkyl groups had been replaced with oxygen during pyrolysis resulting in 21% Q3 and 79% Q4 species. The differences in the masses of APMS following the heat treatment steps (at 110 °C and 600 °C) made it possible to confirm the nature of the chemical species present. From the gravimetric measurements, there were 26% T2 and 74% T3 species after 110 °C heat treatment and 18% Q3 and 82% Q4 species after pyrolysis. The results from NMR and gravimetric analysis were in good agreement. A Langmuir isotherm was applied to estimate the saturated layer coverage of APMS, which was determined using the mass profile of APMS adsorbed on a high-surface-area fumed silica; it showed the saturated layer coverage to be about 0.6 mmol/100 m2.
Protective role of Coenzyme Q<sub>10</sub> in two models of rat lung injury (2009)

The effect of CoQ(10) pretreatment is insufficient to protect the lung against severe ischaemia-reperfusion as may occur in lung transplantation. However, in the setting of less severe pulmonary injury as in anaesthesia and non-transplant surgery, CoQ(10) may have a protective role.
Evaluation of Light Fluence Distribution Using an IR Navigation System for HPPH‐mediated Pleural Photodynamic Therapy (pPDT) (2019)

Uniform light fluence distribution for patients undergoing photodynamic therapy (PDT) is critical to ensure predictable PDT outcomes. However, current practice when delivering intrapleural PDT uses a point source to deliver light that is monitored by seven isotropic detectors placed within the pleural cavity to assess its uniformity. We have developed a real-time infrared (IR) tracking camera to follow the movement of the light point source and the surface contour of the treatment area. The calculated light fluence rates were matched with isotropic detectors using a two-correction factor method and an empirical model that includes both direct and scattered light components. Our clinical trial demonstrated that we can successfully implement the IR navigation system in 75% (15/20) of the patients. Data were successfully analyzed in 80% (12/15) patients because detector locations were not available for three patients. We conclude that it is feasible to use an IR camera-based system to track the motion of the light source during PDT and demonstrate its use to quantify the uniformity of light distribution, which deviated by a standard deviation of 18% from the prescribed light dose. The navigation system will fail when insufficient percentage of light source positions is obtained (<30%) during PDT.
Elevated brain derived neurotrophic factor levels in plasma reflect in vivo functional viability of infused mesenchymal stem cells for stroke in rats (2018)

These results support the hypothesis that BDNF levels in plasma, but not serum, may be more appropriate to detect circulating BDNF in vivo following MSC infusion in a cerebral infarction rat model of ischemic stroke. Further, plasma BDNF might reflect in vivo functional viability of infused MSCs after stroke.
The Nutritional Status of School-Aged Children: Why Should We Care? (2010)

The available data indicate that malnutrition is a public health issue in school-aged children in developing countries and countries in transition. However, the available data, especially data on micronutrient status, are limited. These findings emphasize the need for nutrition interventions in school-aged children and more high-quality research to assess nutritional status in this age group.
Joint inspection of CA153 ,CA125 and FANC in diagnosis of breast cancer (2011)

Objective To investigate the joint inspection of CA153, CA125 and FANC in diagnosis of breast cancer. Methods To detect the blood serum level of CA153,CA125 examination and the FNAC examination separately in 128 breast benign tumor cases and 132 breast cancer cases. Results The CA153 examination's sensitivity was 44.70% , specificity was 95.31%. The CA125 examination's sensitivity was 51.52% , specificity was 94.53%. But the FANC sensitivity was 84.09% , the specificity was 98.44%. Three joint inspection make the sensitivity enhance to 91. 67%, only the specificity slightly reduces to 88.28%. Conclusions FNAC has the high accuracy in breast cancer's diagnosis, but joint inspection with CA153, CA125 can improve the sensitivity of early diagnosis of breast cancer and has some clinical value.

Key words: 
Breast cancer;  Carbohydrate antigen 153;  Carbohydrate antigen 125;  Fine needle aspiration cytology
Oversampled pipeline A/D converters with mismatchshaping (1998)

The authors present a pipeline A/D converter with improved linearity (SNDR). The SNDR improvement is achieved through a combination of oversampling and mismatch shaping, which modulates the distortion energy out-of-band. At an oversampling ratio of four and 64, and a component mismatch of 0.1%, 9 and 35 dB improvements in SNDR are achieved, respectively, in comparison to a converter with no mismatch shaping.
Immunological characterization of a low molecular mass polypeptidic antigen of<i>Borrelia burgdorferi</i> (1991)

The presence of a low molecular mass polypeptidic antigen in Borrelia burgdorferi was described. The protein was exposed at the bacterial surface since it was clearly identified by mAb 3H4 using the immunofluorescence test performed with living bacteria. This antigen was cleaved by proteinase K treatment, whereas it was resistant to the action of chymotrypsin, trypsin and thermolysin. Western blotting analysis of the immunological reactivity of this antigenic structure performed using monoclonal antibody, mouse-immune ascitic fluids raised against B. burgdorferi and other spirochetes, sera from patients with Lyme disease and other infirmities in which false positive results in serological tests for B. burgdorferi have been described, demonstrated that this protein expresses only species-specific epitopes which may be recognized during human B. burgdorferi infections.
Synthesis of Green Emitting Materials for OLED (2011)

We study on the preparation of green emitting materials for organic light emitting device. 3-chromonealdehyde derivatives possessing a conjugated structure, which were composed of electron acceptor of 3-chromonealdehydes and electron donor of diamines, were synthesized by dehydration-condensation process. The structural properties of reaction products were analyzed FT-IR and spectroscopy. The thermal stabilities and reactivities were measured by melting points and yields. The UV-visibles and PL properties can be determined by excitation spectra and emission spectra, respectively.
Compreensão e praxis pedagógica: experiências e atualizações (2010)

O texto relata experiencias de duas professoras com seus estudos e atividades de ensino na pos-graduacao, em torno do tema compreensao e praxis pedagogica. Destaca a aproximacao e o aprofundamento do tema no percurso de cada uma das autoras para elaboracao de suas teses de doutorado; as publicacoes conjuntas e comunicacoes em eventos cientificos e se detem no desenvolvimento de uma disciplina junto a alunas de mestrado e doutorado em educacao na Faculdade de Educacao da UFBA, tomando como sub-titulos do texto, os sub-temas discutidos no curso enfocado. A compreensao e tematizada a partir de uma dimensao ontologica do termo, com o aporte da hermeneutica de Wilhelm Dilthey e de Martin Heidegger em contraponto com a dimensao cognitivista da taxionomia de Benjamim Bloom. As experiencias e atualizacoes sao discutidas a partir do conteudo dos ensaios de alunas participantes do curso. Conclui-se que a despeito da diversidade dos objetos de estudo das alunas e professoras, foi possivel a todas estabelecer articulacoes com o tema proposto e possivelmente realizar experiencias e compreensoes articuladoras. Com isso evidenciou-se o carater formativo desse tema pelas possibilidades de propiciar atualizacoes/experiencias circunscritas ao processo de compreensao.
Origins and effects of variations in spermatozoal quality. (1993)

A traditional view of mammalian fertilization is that the active component of the process, the spermatozoon, by virtue of its progressive motility and acrosomal enzymes, penetrates an otherwise passive oocyte. This concept has placed bias on spermatozoal normality as largely determining the outcome of fertilization. Once this has been achieved, the contribution of the spermatozoon is often forgotten, and attention switches to the maternally derived "blue-print" for early embryonic development. Paternal genomic contribution is known to start at the 8-cell stage in the human, but this is usually after the early cleavage stage embryos are transferred in human reproductive technologies, such as in vitro fertilization (IVF). Hence, any fundamental abnormal contribution to embryogenesis derived from the fertilizing spermatozoon is not seen. IVF has permitted far greater powers of analysis of fertilization in the human, and fertilization success appears to be determined in this system by three main factors: spermatozoal quality, oocyte quality, and the quality of the in vitro culture conditions (the gamete environment). If the second two factors are more carefully controlled than the first, as is the usual emphasis in IVF practice, then any large variation in fertilization rates that is also related to embryonic viability and ultimate pregnancy outcome may be thought to be more directly associated with original quality of the fertilizing spermatozoon. If this hypothesis is accepted, we should drastically alter our concept of the spermatozoon as a robust simple initiator of embryonic development, and embrace the idea of the vulnerability of such germ cells both during and after their production, and how detrimental influences on this may profoundly affect embryogenesis after fertilization.
Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer (2017)

Cancer stem cells (CSCs) have been identified as a subpopulation of stem-like cancer cells with the ability of self-renewal and differentiation in hematological malignancies and solid tumors. Pancreatic cancer is one of the most lethal cancers worldwide. CSCs are thought to be responsible for cancer initiation, progression, metastasis, chemoresistance, and recurrence in pancreatic cancer. In this review, we summarize the characteristics of pancreatic CSCs and discuss the mechanisms involved in resistance to chemotherapy, the interactions with the niche, and the potential role in cancer immunoediting. We propose that immunotherapy targeting pancreatic CSCs, in combination with targeting the niche components, may provide a novel treatment strategy to eradicate pancreatic CSCs and hence improve outcomes in pancreatic cancer.
Adaptive Multipath Equalization for T.V. Broadcasting (1977)

In recent years the growing use of vertical interval data transmission systems in television broadcasting, such as the Captioning for the Deaf system1 developed by the Public Broadcasting Service (PBS)*, has created a renewed interest in the problems of multipath distortion.2 This interest is heightened by the fact that new devices, such as microcomputers and charge coupled delay devices (CCD's), make possible an economic solution to this problem for the first time, not only for data but for video as well3, although the work described herein has concentrated primarily on data applications.
The Use of a Repetitive Differential Analyzer for Finding Roots of Polynomial Equations (1959)

The paper describes a procedure for obtaining real and complex roots of algebraic equations with real or complex coefficients by the use of a repetitive differential analyzer. The procedure requires only operational amplifiers and ganged linear potentiometers. Differential analyzers are very suitable for solving algebraic equations since they permit visual checking of the procedure and make it possible to investigate how the roots of the polynomial are affected by variation of its coefficients. The procedure is not iterative.