gebhart/patrepeval huggingface dataset:
Progress in the Development of CdTe and CdZnTe Semiconductor Radiation Detectors for Astrophysical and Medical Applications (2009)

Over the last decade, cadmium telluride (CdTe) and cadmium zinc telluride (CdZnTe) wide band gap semiconductors have attracted increasing interest as X-ray and gamma ray detectors. Among the traditional high performance spectrometers based on silicon (Si) and germanium (Ge), CdTe and CdZnTe detectors show high detection efficiency and good room temperature performance and are well suited for the development of compact and reliable detection systems. In this paper, we review the current status of research in the development of CdTe and CdZnTe detectors by a comprehensive survey on the material properties, the device characteristics, the different techniques for improving the overall detector performance and some major applications. Astrophysical and medical applications are discussed, pointing out the ongoing Italian research activities on the development of these detectors.
Privacy-preserving location-dependent query processing (2004)

A mobile portable device will often make queries, to a remote database, that depend on its location: It may ask for the nearest coffee shop, restaurant, pharmacy, etc. For privacy reasons, the mobile unit may not wish to disclose its precise location to the remote database - while it is unavoidable that the cell phone company already knows the rough location of the customer (somewhere in Lafayette ), it is quite another matter if the customer's precise location can be tracked over tune through his pattern of location-dependent queries to the remote database. This work describes an efficient protocol, between the client and database, through which a client can learn the answer to its location-dependent query without revealing to the remote database anything about his location, other than what the database can infer from the answer it gives to the query (which is unavoidable). We also analyze the performance of some other, simpler solutions, that do not require the database to run a protocol with the client, but that can reveal more information about the private location and also introduce inaccuracies in the answer - we quantify how much error these simpler schemes introduce in the answer.
A lock method for KBMSs using abstraction relationships' semantics (1994)

Knowledge Base Management Systems (KBMSs) are a growing research area finding applicability in different domains. As a consequence, the demand for ever-larger knowledge bases (KBs) is growing more and more. Inside this context, knowledge sharing turns out to be a crucial point to be supported by KBMSs. In this paper, we propose a way of controlling knowledge sharing. We show how we obtain serializability of transactions providing many different locking granules, which are based on the semantics of the abstraction relationships. The main benefit of our technique is the high degree of potential concurrency, to be obtained through a logical partitioning of the KB graph and the provision of lock types used for each referenced partition. By this way, we capture more of the semantics contained in a KB graph, through an interpretation of its edges grounded in the abstraction relationships, and make feasible a full exploitation of all inherent parallelism in a knowledge representation approach.
Genetic association of α2‐macroglobulin with Alzheimer's disease in a Finnish elderly population (1999)

Recently, two studies have reported an association between the α2-macroglobulin gene on chromosome 12 and late-onset Alzheimer's disease, whereas others have not been able to replicate these findings. By using a prospective population-based study, we have investigated the relation between two polymorphisms in this gene with the presence of the disease and also with the extent of pathological changes in the cerebral cortex. The Vantaa 85+ Study includes all 601 persons, at least 85 years of age, who were living in Vantaa, Finland, on April 1, 1991. The neocortical β-amyloid protein load and the number of neurofibrillary tangles were determined on tissue sections by using methenamine silver staining and a modified Bielschowsky staining, respectively. The A/A genotype in exon 24 of the α2-macroglobulin gene was associated with neuropathologically defined diagnosis of Alzheimer's disease according to the CERAD (Consortium to Establish a Registry for Alzheimer's Disease) criteria and with an increase in the neocortical β-amyloid protein load. The effect of this association was stronger in the apolipoprotein E ε4–negative group. Therefore, genetic variability in the α2-macroglobulin gene is a risk factor associated with neuropathologically defined Alzheimer's disease in our population, as well as with the extent of neocortical β-amyloid protein deposition.
Improving the detection of chronic migraine: Development and validation of Identify Chronic Migraine (ID-CM) (2015)

ID-CM is a simple yet accurate tool that correctly classifies most individuals with migraine and CM. Further testing in other settings will also be valuable.
Reverse time migration in vertical and tilted orthorhombic media (2011)

In this paper we derive a stable second order wave equation for reverse time migration in arbitrarily heterogeneous 3D orthorhombic media (ORT) with vertical and tilted symmetry axis. The formulation is equivalent to the first order elastic wave equation, thus it is physically stable and is a natural extension of the wave equations in VTI and TTI media. We compute the reverse time migration impulse responses for tilted orthorhombic media and demonstrate that our method provides stable and high quality RTM images in more general anisotropy media.
SRM inverter topologies: a comparative evaluation (1991)

Several inverter power circuits suitable for switched reluctance motor (SRM) drives are analyzed and compared. Five inverter circuits are considered with the objective of establishing the most appropriate topology for an SRM drive. The comparison is based on the peak voltage and peak current ratings of the DC link components. Because the power converter choice depends on the motor design, the converter analysis and selection are done for a high-speed, 6/2 SRM suitable for a spindle drive and a high-torque 8/6 motor. Experimental results obtained for a high-torque drive are included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A further comparison of solid-state thermionic and thermoelectric refrigeration (2005)

We show that the expressions for current and heat current calculated via (the non-linearized) ballistic and diffusive transport formalisms reduce to the same form for solid-state devices one electron mean free path in length. The materials parameters for thermionic and thermoelectric devices are also shown to be equal, rather than differing by a multiplicative constant. We derive a simple transport equation that includes both ballistic and diffusive contributions to the current, and, as an example, use this to calculate the maximum temperature difference obtainable for a piece of Bi/sub 2/Te/sub 3/ as a function of its length, from less than an electron mean-free path to much greater than a mean-free path. Finally we briefly discuss similarities and differences between thermionic and thermoelectric devices in the regime where device length is of the order of a mean-free path length.
Progress Toward Clinical Application of the Nitric Oxide–Releasing Diazeniumdiolates (2003)

Diazeniumdiolates, compounds of structure R(1)R(2)NN(O)=NOR(3), which have also been called NONOates, have proven useful for treating an increasing diversity of medical disorders in relevant animal models. Here, I review the chemical features that make them such excellent starting points for designing materials capable of targeting reliable and controllable fluxes of bioactive NO for in vitro and in vivo applications. This is followed by a consideration of recent proof-of-concept studies that underscore what I believe to be the substantial clinical promise of such materials. Examples covered include progress toward inhibiting restenosis after angioplasty, preparing thromboresistant medical devices, reversing vasospasm, and relieving pulmonary hypertension. Together with a very recent report describing the beneficial effects of diazeniumdiolate therapy in a patient with acute respiratory distress syndrome, the results of the animal experiments support the prediction that a broad selection of problems in clinical medicine can be solved by judiciously mining the enormous variety of possible R(1)R(2)NN(O)=NOR(3) structures.
Optimal ofdm design for time-frequency dispersive channels (2003)

Transmission over wireless channels is subject to time dispersion due to multipath propagation and to frequency dispersion due to the Doppler effect. Standard orthogonal frequency-division multiplexing (OFDM) systems, using a guard-time interval or cyclic prefix, combat intersymbol interference (ISI), but provide no protection against interchannel interference (ICI). This drawback has led to the introduction of pulse-shaping OFDM systems. We first present a general framework for pulse shape design. Our analysis shows that certain pulse shapes proposed in the literature are, in fact, optimal in a well-defined sense. Furthermore, our approach provides a simple way to adapt the pulse shape to varying channel conditions. We then show that (pulse-shaping) OFDM systems based on rectangular time-frequency lattices are not optimal for time- and frequency-dispersive wireless channels. This motivates the introduction of lattice-OFDM (LOFDM) systems which are based on general time-frequency lattices. Using results from sphere packing theory, we show how to design LOFDM systems (lattice and pulse shape) optimally for timeand frequency-dispersive channels in order to minimize the joint ISI/ICI. Our theoretical analysis is confirmed by numerical simulations, showing that LOFDM systems outperform traditional pulse-shaping OFDM systems with respect to robustness against ISI/ICI.
Optimal Design of Opamps for Oversampled Converters (1996)

: The power consumption for various opamps used in \\Sigma\\Delta modulators are considered. We first classify the different opamp topologies used in such modulators. We then develop a generalized integrator model that allows us to compare the power consumption for all these topologies. We also derive an expression for the minimum theoretical bound on the power dissipation. We illustrate our results with two design examples: a class A and a class AB opamp. It is shown that class A opamps are the best choice for \\Sigma\\Delta modulators. 1 Introduction Oversampled A/D converters are widely used in instrumentation, data acquisition, telecommunication, and consumer electronics. Some advantages of oversampled A/D converters include a higher dynamic range and signal-to-noise ratio than traditional architectures. Additionally, in these converters the requirement for precisely matched components is relaxed. In this converter the operational amplifier within the modulator is the most critical c...
Adaptive timing synchronization schemes for a short-ranged Bluetooth system (2000)

This paper describes two adaptive timing synchronization schemes for a short-ranged Bluetooth system in the partial-band noise environments. One estimates the variance of the partial-band interference, which is utilized for the trigger threshold value of the inquiry scan and page scan states, while second is designed using the scaled partial correlation value for the connection state. Numerical results show the proposed synchronization algorithms are robust to the partial-band noise interference and of low complexity which is suitable for a low-cost personal area network (PAN).
Singular motions of asymmetric rotators (1976)

An apparatus is described that shows clearly and quantitatively the spectacular motion of free rotating rigid and semirigid bodies moving near their inertial singularities. A geometric construction is shown that makes the theory of this motion clear.
Sugar Content and Activity of Sucrose Metabolism Enzymes in Milled Rice Grain (1989)

Most rice (Oryza sativa L.) cultivars grown in the United States were selected for endosperm starch properties and not soluble sugar content. The minor pool of soluble sugar may affect the qualities of rice as a food. Some cultivar variation in soluble sugar content was detected in milled grain, essentially the starchy endosperm, of long grain varieties. Milled grain of cultivars Lemont and Texmati had a soluble sugar content of 0.21 and 0.35% (w/w), respectively, on a fresh weight basis. The dorsal portion of the milled grain contained the greatest amount of soluble sugar, approximately tenfold the amount found in the central core of the grain. Extracts of the milled grain contained sucrose-phosphate synthase (EC 2.4.1.14) and sucrose synthase (EC 2.4.1.13) activities, which were separated by anion exchange chromatography. The presence of sucrose-phosphate synthase in the rice endosperm suggested a mechanism for sucrose accumulation which might be involved in carbon partitioning during grain development.
The Role of Natural Product Chemistry in Drug Discovery (2004)

Although traditionally natural products have played an important role in drug discovery, in the past few years most Big Pharma companies have either terminated or considerably scaled down their natural product operations. This is despite a significant number of natural product-derived drugs being ranked in the top 35 worldwide selling ethical drugs in 2000, 2001, and 2002. There were 15 new natural product-derived drugs launched from 2000 to 2003, as well as 15 natural product-derived compounds in Phase III clinical trials or registration at the end of 2003. Recently, there has been a renewed interest in natural product research due to the failure of alternative drug discovery methods to deliver many lead compounds in key therapeutic areas such as immunosuppression, anti-infectives, and metabolic diseases. To continue to be competitive with other drug discovery methods, natural product research needs to continually improve the speed of the screening, isolation, and structure elucidation processes, as well addressing the suitability of screens for natural product extracts and dealing with issues involved with large-scale compound supply.
2-(2-Arylphenyl)benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological Evaluation (2014)

The 2-(2-arylphenyl)benzoxazole moiety has been found to be a new and selective ligand for the enzyme cyclooxygenase-2 (COX-2). The 2-(2-arylphenyl)benzoxazoles 3a-m have been synthesized by Suzuki reaction of 2-(2-bromophenyl)benzoxazole. Further synthetic manipulation of 3f and 3i led to 3o and 3n, respectively. The compounds 3g, 3n, and 3o selectively inhibited COX-2 with selectivity index of 3n much better than that of the COX-2 selective NSAID celecoxib. The in vivo anti-inflammatory potency of 3g and 3n is comparable to that of celecoxib and the nonselective NSAID diclofenac at two different doses, and 3o showed better potency compared to these clinically used NSAIDs.
Highly Asymmetrical Glycerol Diether Bolalipids: Synthesis and Temperature-Dependent Aggregation Behavior (2015)

In the present work, we describe the synthesis and temperature-dependent aggregation behavior of two examples of a new class of highly asymmetrical glycerol diether bolaphospholipids. The bolalipids contain a long alkyl chain (C32) bound to glycerol in the sn-3 position, carrying a hydroxyl group at the ω position. The C16 alkyl chain in the sn-2 position either possesses a racemic methyl branch at the 10 position of the short alkyl chain (lipid II) or does not (lipid I). The sn-1 position of the glycerol is linked to a zwitterionic phosphocholine moiety. The temperature-dependent aggregation behavior of both bolalipids was studied using differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy, and X-ray scattering. Aggregate structures were visualized by transmission electron microscopy (TEM). We show that both bolalipids self-assemble into large lamellar sheetlike aggregates. Closed lipid vesicles or other aggregate structures such as tubes or nanofibers, as usually found for diglycerol tetraether lipids, were not observed. Within the lamellae the bolalipid molecules are arranged in an antiparallel (interdigitated) orientation. Lipid I, without an additional methyl moiety in the short alkyl chain, shows a lamellar phase with high crystallinity up to a temperature of 34 °C, which was not observed before for other phospholipids.
Stationary Phases for the Separation of Reducing Sugars by Normal-Phase Partition Chromatography (2014)

High-performance liquid chromatography (HPLC) has great contribution in the analysis of the carbohydrates. Various separation modes such as ion exchange chromatography, size exclusion chromatography and partition chromatography have been applied to HPLC of mono- and oligosaccharides. Among them, partition chromatography with a polar stationary phase and aqueous mobile phase, called aqueous normal phase partition (ANP) chromatography, has been used in various fields, and is widely used for the separation of reducing sugars. Currently, this separation mode is considered to be a type of "hydrophilic interaction chromatography (HILIC)". As the use of HILIC mode increases, many novel stationary phases being available for the separation of reducing sugars have been developed. This article focuses on the separation of reducing sugars by ANP (HILIC) mode, and summarizes the traditional and/or recent stationary phases for the separation of reducing sugars. The applicability of various kinds of stationary phases to solid-phase extraction (SPE) of saccharides is also described.
Evaluation of the Immunomodulatory Activity of the Chicken NK-Lysin-Derived Peptide cNK-2 (2017)

Chicken NK-lysin (cNK-lysin), the chicken homologue of human granulysin, is a cationic amphiphilic antimicrobial peptide (AMP) that is produced by cytotoxic T cells and natural killer cells. We previously demonstrated that cNK-lysin and cNK-2, a synthetic peptide incorporating the core α-helical region of cNK-lysin, have antimicrobial activity against apicomplexan parasites such as Eimeria spp., via membrane disruption. In addition to the antimicrobial activity of AMPs, the immunomodulatory activity of AMPs mediated by their interactions with host cells is increasingly recognized. Thus, in this study, we investigated whether cNK-lysin derived peptides modulate the immune response in the chicken macrophage cell line HD11 and in chicken primary monocytes by evaluating the induction of chemokines, anti-inflammatory properties, and activation of signalling pathways. cNK-2 induced the expression of CCL4, CCL5 and interleukin(IL)-1β in HD11 cells and CCL4 and CCL5 in primary monocytes. We also determined that cNK-2 suppresses the lipopolysaccharide-induced inflammatory response by abrogating IL-1β expression. The immunomodulatory activity of cNK-2 involves the mitogen-activated protein kinases-mediated signalling pathway, including p38, extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinases, as well as the internalization of cNK-2 into the cells. These results indicate that cNK-2 is a potential novel immunomodulating agent rather than an antimicrobial agent.
De novotranscriptome characterization of Vitis vinifera cv. Corvina unveils varietal diversity (2013)

The de novo assembly approach allowed a substantial amount of the Corvina transcriptome to be reconstructed, improving known gene annotations by robustly defining gene structures, annotating splice isoforms and detecting genes without annotations. The private genes we discovered are likely to be nonessential but could influence certain cultivar-specific characteristics. Therefore, the application of de novo transcriptome assembly should not be restricted to species lacking a reference genome because it can also improve existing reference genome annotations and identify novel, cultivar-specific genes.
Isolation of cDNA clones and complete amino acid sequence of human erythrocyte glycophorin C. (1986)

Two cDNA clones for glycophorin C, a transmembrane glycoprotein of the human erythrocyte which carries the blood group Gerbich antigens, have been isolated from a human reticulocyte cDNA library. The clones were identified with a mixture of 32 oligonucleotide probes (14-mer) which have been synthetized according to the amino acid sequence Asp-Pro-Gly-Met-Ala present in the N-terminal tryptic peptide of the molecule. The primary structure of glycophorin C deduced from the nucleotide sequence of the 460 base-pair insert of the pGCW5 clone indicates that the complete protein is a single polypeptide chain of 128 amino acids clearly organized in three distinct domains. The N-terminal part (residues 1-57, approximately) which is N- and O-glycosylated is connected to a hydrophilic C-terminal domain (residues 82-128, approximately) containing 4 tyrosine residues by a hydrophobic stretch of nonpolar amino acids (residues 58-81, approximately) probably interacting with the membrane lipids and permitting the whole molecule to span the lipid bilayer. Northern blot analysis using a 265-base-pair restriction fragment obtained by DdeI digestion of the inserted DNA shows that the glycophorin C mRNA from human erythroblasts is approximately 1.4 kilobases long and is present in the human fetal liver and the human K562 and HEL cell lines which exhibit erythroid features. The glycophorin C mRNA, however, is absent from adult liver and lymphocytes, indicating that this protein represents a new erythrocyte-specific probe which might be useful to study erythroid differentiation.
Variability in near-surface particulate absorption spectra: What can a satellite ocean color imager see? (1994)

An extensive database of ∼400 in situ particulate absorption spectra [ap(λ)] is analyzed to assess the potential of using ocean color imagers to examine variability in the structure of the near-surface ocean planktonic ecosystem. This application of ap(λ) data is appropriate, as particulate absorption variations are the dominant source of ocean color variation and are attributable to changes in the phytoplankton community structure. Empirical orthogonal function (EOF) analyses are used to estimate the contribution of each statistical mode to the total variance. The EOF analyses showed that >99% of the variance found in the ap(λ) data set can be simply attributed to the total amount of particulate material. When this source of variability is removed, two significant modes of variability can be identified which comprise 79 and 18% of the normalized variance. These modes are interpreted as representing the relative contribution of chlorophyll-containing biomass and detrital materials, verifying the use of two-component phytoplankton-detritus models to partition ap(λ). Only a small amount of the total ap(λ) variability (<0.5% of the total) can be attributed to absorption features caused by accessory pigment groups. Thus, variability in ap(λ) is almost entirely associated with the quantity of the absorbing materials rather than their spectral quality (or normalized spectral shape). These results suggest that remotely sensed ocean color spectra will reflect only three statistically significant components: the total amount of particulate material, the relative amounts of chlorophyll-containing biomass, and detrital materials. For most typical conditions it is unlikely that robust global algorithms for determining particular phytoplankton groups can be developed from remotely sensed ocean color spectra.