gebhart/patrepeval huggingface dataset:
Context-aware management for sensor networks (2011)

The wide field of wireless sensor networks requires that hundreds or even thousands of sensor nodes have to be maintained and configured. With the upcoming initatives such as Smart Home and Internet of Things, we need new mechanism to discover and manage this amount of sensors. In this paper, we describe a middleware architecture that uses context information of sensors to supply a plug-and-play gateway and resource management framework for heterogeneous sensor networks. Our main goals are to minimise the effort for network engineers to configure and maintain the network and supply a unified interface to access the underlying heterogeneous network. Based on the context information such as battery status, routing information, location and radio signal strength the gateway will configure and maintain the sensor network. The sensors are associated to nearby base stations using an approach that is adapted from the 802.11 WLAN association and negotiation mechanism to provide registration and connectivity services for the underlying sensor devices. This abstracted connection layer can be used to integrate the underlying sensor networks into high-level services and applications such as IP-based networks and Web services.
INTRAGRAFT EXPRESSION OF SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION (STATS) AND SUPPRESSORS OF CYTOKINE SYNTHESIS (SOCS) MOLECULES IN REJECTION VS. TOLERANCE. (2000)

Ozkaynak, Engin1; Gao, Wei1; Csizmadia, Vilmos1; King, Jennifer A.1; Turka, Laurence A.2; Hancock, Wayne W.1,3 Author Information
Sniffer dogs as part of a bimodal bionic research approach to develop a lung cancer screening (2012)

Lung cancer (LC) continues to represent a heavy burden for health care systems worldwide. Epidemiological studies predict that its role will increase in the near future. While patient prognosis is strongly associated with tumour stage and early detection of disease, no screening test exists so far. It has been suggested that electronic sensor devices, commonly referred to as 'electronic noses', may be applicable to identify cancer-specific volatile organic compounds in the breath of patients and therefore may represent promising screening technologies. However, three decades of research did not bring forward a clinically applicable device. Here, we propose a new research approach by involving specially trained sniffer dogs into research strategies by making use of their ability to identify LC in the breath sample of patients.
Small-Molecule Screening Using a Whole-Cell Viral Replication Reporter Gene Assay Identifies 2-{[2-(Benzoylamino)Benzoyl]Amino}-Benzoic Acid as a Novel Antiadenoviral Compound (2010)

Adenovirus infections are widespread in society and are occasionally associated with severe, but rarely with life-threatening, disease in otherwise healthy individuals. In contrast, adenovirus infections present a real threat to immunocompromised individuals and can result in disseminated and fatal disease. The number of patients undergoing immunosuppressive therapy for solid organ or hematopoietic stem cell transplantation is steadily increasing, as is the number of AIDS patients, and this makes the problem of adenovirus infections even more urgent to solve. There is no formally approved treatment of adenovirus infections today, and existing antiviral agents evaluated for their antiadenoviral effect give inconsistent results. We have developed a whole cell-based assay for high-throughput screening of potential antiadenoviral compounds. The assay is unique in that it is based on a replication-competent adenovirus type 11p green fluorescent protein (GFP)-expressing vector (RCAd11pGFP). This allows measurement of fluorescence changes as a direct result of RCAd11pGFP genome expression. Using this assay, we have screened 9,800 commercially available small organic compounds. Initially, we observed approximately 400 compounds that inhibited adenovirus expression in vitro by > or = 80%, but only 24 were later confirmed as dose-dependent inhibitors of adenovirus. One compound in particular, 2-{[2-(benzoylamino)benzoyl]amino}-benzoic acid, turned out to be a potent inhibitor of adenovirus replication.
Botines e indemnizaciones, la economía romana de guerra entre Cartagena y Pidna (2001)

Aquest treball vol aportar elements quantitatius que ajuden a confeccionar un balanç econòmic a la Roma de finais del segle III a. C. 1ª meitat del II a. C., considerant els ingresos de l’època com capítols extraordinaris d’un pressupost que els romans mai el•laboraren, llevat de la previsió d’obtenir enormes guanys en cadascuna de les campanyes militars, enriquint als comandants i sostenint l’estat a costa dels vençuts.
Detection of Mullerian Inhibiting Substance in Biological Samples by a Solid Phase Sandwich Radioimmunoassay (1986)

Mullerian inhibiting substance (MIS) is a 140,000-dalton glycoprotein responsible for regression of Miillerian ducts in a male embryo. It has recently been demonstrated that MIS inhibits the growth of tumors in vivo and in vitro. In this study, we have constructed a sensitive, solid phase sandwich RIA using monoclonal antibodies raised to bovine MIS. The amount of MIS detected was based on the protein concentration of Green 3, the most purified fraction of MIS available. The assay could detect 20 ng Green 3 or 0.14 pmol in physiological samples. There was no evidence of cross-reactivity of the antibodies raised to bovine MIS with chicken, rat, mouse, or human MIS. (Endocrinology118: 791-796,1986)
Visual-inertial SLAM for a small helicopter in large outdoor environments (2012)

In this video, we present our latest results towards fully autonomous flights with a small helicopter. Using a monocular camera as the only exteroceptive sensor, we fuse inertial measurements to achieve a self-calibrating power-on-and-go system, able to perform autonomous flights in previously unknown, large, outdoor spaces. Our framework achieves Simultaneous Localization And Mapping (SLAM) with previously unseen robustness in onboard aerial navigation for small platforms with natural restrictions on weight and computational power. We demonstrate successful operation in flights with altitude between 0.2-70 m, trajectories with 350 m length, as well as dynamic maneuvers with track speed of 2 m/s. All flights shown are performed autonomously using vision in the loop, with only high-level waypoints given as directions.
Treatment of Homozygous Protein C Deficiency and Neonatal Purpura Fulminans with a Purified Protein C Concentrate (1991)

PROTEIN C is a vitamin K—dependent glycoprotein circulating in plasma as an inactive zymogen.1 It is converted to the serine protease—activated protein C, a natural anticoagulant that inactivates factors V and VIII after they are activated by thrombin during the coagulation process.2 , 3 The homozygous and double heterozygous forms of congenital protein C deficiency can result in life-threatening neonatal thrombosis and purpura fulminans, diseases that are frequently associated with disseminated intravascular coagulation.4 , 5 At least 19 cases have been reported.4 , 6 7 8 9 10 11 The predominant clinical signs of purpura fulminans consist of ecchymotic skin lesions that spontaneously become necrotic.12 , 13 We describe the case of an . . .
The Automatic Measurement System for Harmonic-drive Devices (2019)

Abstract Harmonic-drive transmission finds many applications in industry, especially in manufacturing of industrial robots. As the key devices of an industrial robot, the harmonic drive reducers determine the robot’s performance, which includes the positioning accuracy, loading capacity, life time, etc. To satisfy the need of manufacturing high performance harmonic drive devices, development of competent measurement system is of great importance. An automatic measurement system with high-precision and multifunction is under development. The system consists of the power module, loading module, torque and rotation measuring module. The measurement and operation principle were explained. The factors affecting the accuracy of the measurement system were analysed. The control system was designed to realize the automatic loading and acquisition of torque and rotation data. The principle and measurement software of the control system were also introduced. Finally, a harmonic reducer with the gear ratio 120 was measured to verify the feasibility of the measurement system.
Improving the Cherenkov Based PET Performance Using Multi-Layer Detectors (2019)

Positron emission tomography (PET) images can be improved by including measurement of time-of-flight (TOF) information in image reconstruction. The accuracy of the TOF measurement is currently limited by the time response of the scintillator crystal. One open possibility to develop new devices is to search for new materials with faster light emission mechanisms such as the Cherenkov light emitted by electrons moving in a material with velocities exceeding the speed of light in the material. This enables excellent time resolution. On the other hand, the travel time spread of photons inside crystals of sufficient length for PET application represents a fundamental limitation for the TOF resolution. One possibility to improve the timing without affecting gamma stopping power is to use a multi-layer detector geometry. In this work we have explored a multi-layer detector for Cherenkov PET using annihilation gammas from a sodium source ( <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">22</sup> Na). When incorporating silicon photomultiplier (SiPM) photodetectors, Cherenkov PET detectors could be realized at a very competitive price. Due to their compact size, SiPMs also enable the construction of a multi-layer detector.
Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration (2015)

Trisomy 21 (T21), Down Syndrome (DS) is the most common genetic cause of dementia and intellectual disability. Modeling DS is beginning to yield pharmaceutical therapeutic interventions for amelioration of intellectual disability, which are currently being tested in clinical trials. DS is also a unique genetic system for investigation of pathological and protective mechanisms for accelerated ageing, neurodegeneration, dementia, cancer, and other important common diseases. New drugs could be identified and disease mechanisms better understood by establishment of well-controlled cell model systems. We have developed a first nonintegration-reprogrammed isogenic human induced pluripotent stem cell (iPSC) model of DS by reprogramming the skin fibroblasts from an adult individual with constitutional mosaicism for DS and separately cloning multiple isogenic T21 and euploid (D21) iPSC lines. Our model shows a very low number of reprogramming rearrangements as assessed by a high-resolution whole genome CGH-array hybridization, and it reproduces several cellular pathologies seen in primary human DS cells, as assessed by automated high-content microscopic analysis. Early differentiation shows an imbalance of the lineage-specific stem/progenitor cell compartments: T21 causes slower proliferation of neural and faster expansion of hematopoietic lineage. T21 iPSC-derived neurons show increased production of amyloid peptide-containing material, a decrease in mitochondrial membrane potential, and an increased number and abnormal appearance of mitochondria. Finally, T21-derived neurons show significantly higher number of DNA double-strand breaks than isogenic D21 controls. Our fully isogenic system therefore opens possibilities for modeling mechanisms of developmental, accelerated ageing, and neurodegenerative pathologies caused by T21.
ChemInform Abstract: HETEROCYCLIC ANALOGS OF PLEIADIENE. 50. SULFONATION OF PERIMIDINES, PERIMIDONES, AND 2,3‐DIHYDROPERIMIDINES (1980)

Abstract Die Sulfonierung der Perimidine (I), des Perimidons (III) und des Dihydroperimidins (V) erfolgt stets in 6‐Stellung.
Multiple sequence alignment modeling: methods and applications (2015)

This review provides an overview on the development of Multiple sequence alignment (MSA) methods and their main applications. It is focused on progress made over the past decade. The three first sections review recent algorithmic developments for protein, RNA/DNA and genomic alignments. The fourth section deals with benchmarks and explores the relationship between empirical and simulated data, along with the impact on method developments. The last part of the review gives an overview on available MSA local reliability estimators and their dependence on various algorithmic properties of available methods.
Mo[N(<i>t</i>-Bu)(Ar)]<sub>3</sub>Complexes As Catalyst Precursors:  In Situ Activation and Application to Metathesis Reactions of Alkynes and Diynes (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTMo[N(t-Bu)(Ar)]3 Complexes As Catalyst Precursors: In Situ Activation and Application to Metathesis Reactions of Alkynes and DiynesAlois Fürstner, Christian Mathes, and Christian W. LehmannView Author Information Max-Planck-Institut für Kohlenforschung D-45470 Mülheim/Ruhr, Germany Cite this: J. Am. Chem. Soc. 1999, 121, 40, 9453–9454Publication Date (Web):September 23, 1999Publication History Received26 April 1999Published online23 September 1999Published inissue 1 October 1999https://pubs.acs.org/doi/10.1021/ja991340rhttps://doi.org/10.1021/ja991340rrapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views3669Altmetric-Citations199LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Additives,Aromatic compounds,Catalysts,Hydrocarbons,Metathesis Get e-Alerts
Adaptive CPFSK modulation for power line communications (2002)

Power-line communication (PLC) has an advantage of no additional wiring for communications, but it may not be suitable for high speed signal transmission due to the nature of power-line. In this paper we consider the use of adaptive CPFSK modulation scheme robust to harsh power-line channel condition. The modulation parameters are initialized and adjusted during the data transmission without interrupt. The performance of the proposed scheme is analyzed and verified by computer simulation.
Exact computation of a sum or difference with applications to argument reduction (2002)

Results are presented that identify when the computed value of a sum or difference is exact. The accuracy of an argument reduction algorithm is analyzed using these results. This analysis demonstrates that catastrophic cancellation does not occur in this algorithm's computation of the reduced argument.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Tailored theranostic apolipoprotein E3 porphyrin-lipid nanoparticles target glioblastoma (2017)

The development of curative glioblastoma treatments and tumour-specific contrast agents that can overcome the blood-brain barrier (BBB) and infiltrative tumour morphology remains a challenge. Apolipoprotein E3 (apoE3) is a high density lipoprotein apolipoprotein that chaperones the transcytosis of nanoparticles across the BBB, and displays high-affinity binding with the low density lipoprotein receptor (LDLR), a cell-surface receptor overexpressed by glioblastoma cells. This LDLR overexpression and apoE3 binding capacity was exploited for the development of glioblastoma-targeted porphyrin-lipid apoE3 lipid nanoparticles (pyE-LNs) with intrinsic theranostic properties. Size-controlled discoidal and cholesteryl oleate (CO)-loaded spherical pyE-LNs were synthesized through the systematic variation of particle composition, which dictated nanoparticle size and morphology. Composition optimization yielded 30 nm pyE-LNs with stable loading of apoE3 and porphyrin-lipid that simultaneously conferred the nanoparticles with glioblastoma targeting and activatable near-infrared fluorescence imaging functionalities. A 4-fold higher uptake of pyE-LNs by LDLR-expressing U87 glioblastomas cells relative to minimally expressing ldlA7 cells was observed <i>in vitro</i>. This uptake was a result of receptor-mediated endocytosis, which could be inhibited through LDL competition and acetylation of particle apoE3 moieties. ApoE3-dependent delivery of pyE-LN to glioblastomas was also demonstrated in orthotopic U87-GFP tumour-bearing animals. Quantification of CO-loaded pyE-LN biodistribution demonstrated successful selective uptake of porphyrin by malignant tissue, with a 4 : 1 tumour : healthy tissue particle specificity. This allowed for the detection of strong, tumour-localized porphyrin fluorescence, which was diminished when apoE3-devoid py-LN particles were administered. Furthermore, this selective uptake yielded cell-specific potent PDT sensitization <i>in vitro</i>, resulting in an 83% reduction in glioblastoma cell viability. These results highlight the promising capacity of pyE-LNs to target porphyrin delivery to glioblastoma tumours for theranostic applications.
Gas Lift Optimization Efforts and Challenges (1999)

Abstract Gas lift plays an important role in Esso Production Malaysia Inc. (EPMI) oil production operation. As oil fields mature, the production facilities need to handle increasing water and gas. Gas lift optimization is crucial to ensure maximum oil production within facility constraints. Nodal analysis, Gas lift Optimization Allocation model (GOAL), gas lift databases and Gas Lift Monitoring System (GLMS) are among the tools applied to meet the objective. Some of the challenges encountered during the gas lift optimization efforts are dual gas lift optimization, tight dummy valve retrieval at one particular platform, production from thin oil column, emulsion and sand production.
Polymerization of ethylene oxide with a calixarene‐based precursor: Synthesis of eight‐arm poly(ethylene oxide) stars by the core‐first methodology (2003)

Abstract Eight‐arm poly(ethylene oxide) (PEO) stars were prepared by the core‐first method with a newly designed octahydroxylated precursor. This compound was readily obtained in two steps from commercially available tert ‐butylcalix[8]arene. The choice of the proper solvent of polymerization proved crucial to obtain PEO star materials with a narrow distribution of molar masses. For instance, the use of dimethyl sulfoxide (DMSO) resulted in PEO samples of rather large polydispersities (PDI: 1.3–1.5). In this solvent, the calixarene‐based precursor was only sparingly soluble, and an attempt to metalate its eight hydroxyl groups produced insoluble alkoxides. In addition, the presence of a side population of low‐molar‐mass species attributable to linear chains was detected because of the chain transfer of propagating alkoxides to DMSO. Polymerization experiments carried out in tetrahydrofuran (THF) as solvent afforded better control over the molar masses and PDIs. This was related to the better solubility of the octafunctional calixarene‐based precursor in THF and to the small tendency of the alkoxides formed to aggregate in that solvent. Under such conditions, all eight hydroxyl functions efficiently initiated the polymerization of ethylene oxide. In this way, well‐defined PEO stars (PDI < 1.2) of tunable molar masses incorporating a calixarene‐based core could be obtained, as it was supported by the characterization of the samples by size exclusion chromatography, NMR, and viscometry. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 1669–1676, 2003
Production of Antipeptide Antibodies (2010)

Peptides (8-20 residues) are as effective as proteins in raising antibodies, both polyclonal and monoclonal with a titer above 20,000 easily achievable. A successful antipeptide antibody production depends on several factors such as peptide sequence selection, peptide synthesis, peptide-carrier protein conjugation, the choice of the host animal, and antibody purification. Peptide sequence selection is likely the most difficult and critical step in the development of antipeptide antibodies. Although the format for designing peptide antigens is not precise, several guidelines can help maximize the likelihood of producing high-quality antipeptide antibodies. Typically, 5-20 mg of peptide is enough for raising an antibody, for preparing a peptide affinity column, and for antibody titer determination using an enzyme-linked immunosorbent assay (ELISA). Usually, it takes 3 months to raise a polyclonal antipeptide antibody from a rabbit that yields ~90 mL of serum which translates into approximately 8-10 mg of the specific antibody after peptide affinity purification.
Parvovirus NS1 stimulates P4 expression by interaction with the terminal repeats and through DNA amplification (1991)

Parvovirus protein NS1 is required for replication of viral DNA and plays a role in the regulation of viral gene expression. NS1 trans-activates the P38 promoter for capsid protein synthesis and has variable effects on other promoters. In this study, we examined the effects of NS1 on the regulation of its own promoter, P4. A number of plasmid constructions were made with the P4 promoter fused to reporter genes. The effects of NS1 on expression from the P4 promoter differed depending on the construction. Plasmids containing viral sequences which could not replicate showed a decrease in P4 expression on cotransfection with the NS1 gene. However, plasmids having replication-proficient viral sequences showed a three- to fivefold increase in P4 expression dependent on NS1. The effect on NS1 on P4 transcription was also evaluated at the steady-state RNA level. An infectious clone of the LuIII viral genome was modified to an NS1-NS2 null mutant (pLu272) that is competent for viral DNA replication by introducing a frameshift mutation at codon 5 of the NS1 open reading frame. The P4 transcripts of pLu272 are four nucleotides longer than the wild type and can therefore be resolved from the wild type by primer extension analysis. pLu272 allows comparison of the constitutive level of steady-state RNA produced by the pLu272 P4 promoter in the absence or presence of a template replication dependent on NS1 supplied in trans. NS1 increased P4 transcripts about six- to eightfold. Expression of P4 transcripts from clones that could not amplify depended on the presence of an intact inverted terminal repeat sequence at the left end. A clone with an intact viral left end and a defective viral right end gave an NS1-dependent threefold increase in P4 expression. Destruction of terminal hairpins at both ends resulted in no significant increase in P4 expression in the presence of NS1. Thus, the positive effect of NS1 on the steady-state levels of P4 transcripts depends on the amplification of gene copy number and the integrity of the terminal repeats.