gebhart/patrepeval huggingface dataset:
Preliminaryin vivo studies on the osteogenic potential of bone morphogenetic proteins delivered from an absorbable puttylike polymer matrix (2000)

This article describes preliminary in vivo studies evaluating the osteogeneic potential of bone morphogenetic proteins (BMPs) delivered from an absorbable puttylike polymer matrix. In the first study, bovine-derived bone morphogenetic proteins were incorporated in an polymer matrix consisting of 50:50 poly(DL-lactide-co-glycolide) dissolved in N-methyl-2-pyrrolidone. The matrix was implanted in an 8 mm critical-size calvarial defect created in the skull of adult Sprague-Dawley rats (n = 5 per treatment group). After 28 days, the implant sites were removed and examined for new bone formation, polymer degradation, and tissue reaction. Gamma-irradiated polymer matrices appeared to give more bone formation than nonirradiated samples (histological analysis; 2. 76 + 1.34 mm(2) of bone versus 1.30 + 0.90 mm(2) of bone, respectively and x-ray analysis; 27.2 + 15.9 mm(2) of bone versus 20. 7 + 16.7 mm(2) of bone, respectively) and less residual polymer (0.0 + 0.0 versus 0.2 + 0.4, respectively). The polymer implants with bone morphogenetic protein also gave less inflammatory response than the polymer controls (gamma irradiated polymer/BMP = 1.8 + 0.4 and nonirradiated polymer/BMP = 1.2 + 0.4 versus polymer only = 3.0 + 1. 2, respectively). However, despite trends in both the x-ray and histological data there was no statistical difference in the amount of new bone formed among the four treatment groups (P > 0.05). This was most likely due to the large variance in the data scatter and the small number of animals per group. In the second animal study, bovine-derived BMPs and the polymeric carrier were gamma irradiated separately, at doses of 1.5 or 2.5 Mrad, and their ability to form bone in a rat skull onlay model was evaluated using Sprague-Dawley rats (n = 5 per treatment group). Histomorphometry of skull caps harvested 28 days after implantation showed no significant differences as compared to non-irradiated samples, in implant area, new bone area, and percent new bone (P > 0.05). These results suggest gamma irradiation may be useful in sterilization of the bovine-derived BMPs and the polymeric carrier for potential bone repair and/or regeneration applications.
Determination of on-line differential refractive index and molecular weight via gradient HPLC interfaced with low-angle laser light scattering, ultraviolet, and refractive index detection (1993)

Gradient ion-exchange chromatography (IEC) was interfaced with a low-angle laser light scattering photometer (LALLS) and ultraviolet (UV) and refractive index (RI) detectors connected in series for on-line determination of the differential refractive index (dn/dc) of proteins and eventually their molecular weights (Mw's). Interfacing of gradient HPLC with a RI detector was made possible by using two isorefractive buffers, which helped generate stable baselines for the LALLS and RI detectors. An optically modified, laser based RI detector was used for determination of dn/dc. On-line determinations of dn/dc required smaller amounts of sample compared to off-line determinations (3-4 mg vs 200 mg). Also, dn/dc could be measured by making one repetitive injection of the sample, if the molar absorptivity of the sample was known. dn/dc values determined on-line were in close agreement with those determined off-line. Additionally, percent recovery of the sample was calculated on-line, and this provided true concentration detected at the UV detector, which was then used for determination of Mw.
A New Way to Silicon Microstructuring with Electrochemical Etching (2000)

Porous silicon layers etched through openings in an inert masking layer have been employed to produce microstructures in silicon. In order to overcome the isotropic nature of the porous silicon formation process around the mask edges, optimized organic electrolytes for etching macropores on p-type silicon were employed. New kinds of pores (dubbed “trenches”) were found, which are sensitive to mechanical stress and may prove useful for microstructuring silicon. Systematic experiments are presented which investigate the stability, the crystal orientation dependence, and limitations of trench formation. A possible mechanism for the trench formation is discussed in terms of the “current burst” model.
Prospects for three‐dimensional projective and tomographic imaging radar networks (1984)

Results of a study demonstrating the feasibility of broadband and speckle‐free projective imaging of a complex shaped scattering object in the 6‐17 GHz range with centimeter resolution are presented. We show how angular, spectral, and polarization diversities can be combined in the data acquisition process, with a unique target‐derived reference technique to access the three‐dimensional Fourier space of the scatterer cost‐effectively. Image retrieval algorithms, based on the projection slice theorem and knowledge of object symmetry, are utilized in obtaining images of a model aircraft with near optical resolution. The implications for high‐resolution three‐dimensional tomographic imaging radar networks are discussed.
PRL-3 Initiates Tumor Angiogenesis by Recruiting Endothelial Cells <i>In vitro</i> and <i>In vivo</i> (2006)

We show here that PRL-3 protein is expressed in fetal heart, developing blood vessels, and pre-erythrocytes but not in their mature counterparts. These observations imply that PRL-3 may be involved in the early development of the circulatory system. Because PRL-3 mRNA had been reported to be consistently elevated in metastatic samples derived from colorectal cancers, we attempted to investigate if PRL-3 might be involved in tumor angiogenesis and if PRL-3-expressing cells could cross-talk to human umbilical vascular endothelial cells (HUVEC) by using an in vitro coculture system. HUVECs were grown with fibroblasts, which were later overlaid with PRL-3-expressing cells. We observed that both PRL-3-expressing Chinese hamster ovary (CHO) cells and PRL-3-expressing DLD-1 human colon cancer cells could redirect the migration of HUVECs toward them; in addition, PRL-3-expressing DLD-1 cells could enhance HUVEC vascular formation. In vivo injection of PRL-3-expressing CHO cells into nude mice to form local tumors resulted in the recruitment of host endothelial cells into the tumors and initiation of angiogenesis. We further showed that PRL-3-expressing cells reduced interleukin-4 (IL-4) expression levels and thus attenuated IL-4 inhibitory effects on the HUVEC vasculature. Our findings provide direct evidence that PRL-3 may be involved in triggering angiogenesis and establishing microvasculature and it may serve as an attractive therapeutic target with respect to both angiogenesis and cancer metastasis.
Learning Generalized Linear Models Over Normalized Data (2015)

Enterprise data analytics is a booming area in the data management industry. Many companies are racing to develop toolkits that closely integrate statistical and machine learning techniques with data management systems. Almost all such toolkits assume that the input to a learning algorithm is a single table. However, most relational datasets are not stored as single tables due to normalization. Thus, analysts often perform key-foreign key joins before learning on the join output. This strategy of learning after joins introduces redundancy avoided by normalization, which could lead to poorer end-to-end performance and maintenance overheads due to data duplication. In this work, we take a step towards enabling and optimizing learning over joins for a common class of machine learning techniques called generalized linear models that are solved using gradient descent algorithms in an RDBMS setting. We present alternative approaches to learn over a join that are easy to implement over existing RDBMSs. We introduce a new approach named factorized learning that pushes ML computations through joins and avoids redundancy in both I/O and computations. We study the tradeoff space for all our approaches both analytically and empirically. Our results show that factorized learning is often substantially faster than the alternatives, but is not always the fastest, necessitating a cost-based approach. We also discuss extensions of all our approaches to multi-table joins as well as to Hive.
Pharmacodynamics of propiverine and three of its main metabolites on detrusor contraction (2005)

1. Besides its antimuscarinic effects, propiverine may possess an additional mode of action. We compared the effects of propiverine, three of its metabolites (M-5, M-6, M-14) and atropine in human, pig and mouse urinary bladder preparations in order to elucidate the nature of a possible additional mode of action. 2. Like the parent compound, M-5, M-6 and M-14 reduced to variable degrees the contractions elicited by electric field stimulation (EFS) of isolated, urothelium-denuded detrusor strips. In mouse the atropine-resistant and therefore the nonadrenergic, noncholinergic component of contractile response to EFS was reduced by M-5, M-14 and propiverine, but was hardly affected by M-6. 3. Atropine, propiverine and M-6 significantly shifted the cumulative concentration-response curves for carbachol (CCh) to higher concentrations. Atropine and M-6 did not affect the maximum tension induced by CCh. Propiverine, M-5 and M-14 reduced the maximum CCh effect, suggesting at least one additional mode of action. This pattern of response was observed in all the three species, albeit with some differences in sensitivity to the various agents. 4. In freshly isolated human detrusor smooth muscle cells, propiverine and M-14 inhibited the nifedipine-sensitive L-type calcium current (I(Ca)) in a concentration-dependent manner. In contrast, the effects of M-5 and M-6 on I(Ca) were insignificant in the concentration range examined. 5. The investigated responses to propiverine and its metabolites suggest that impairment of maximum CCh-induced contractions is due to strong effect on I(Ca) and that this may be associated with the presence of the aliphatic side chain.
Geldanamycin, an inhibitor of the chaperone activity of HSP90, induces MAPK‐independent cell cycle arrest (2004)

The effects of GA, an ansamycin antibiotic in development as a lead anticancer drug, were studied in mouse BP-A31 fibroblasts and in human cancer-derived cell lines. GA and related molecules act by inhibiting the chaperone function of the Hsp90 protein through competition for ATP binding. The antiproliferative effects of GA have been attributed to destabilization of the Raf-1 protein, one of the targets of Hsp90, and to the resulting inhibition of MAPK. Addition of GA to BP-A31 cells, synchronously progressing through the G(1) phase, inhibited Rb hyperphosphorylation and G(1)/S transition irrespective of the time of addition. The G(1) arrest was accompanied by a progressive decrease in Raf-1 content, especially of the phosphorylated form; however, GA caused only partial inhibition of MAPK phosphorylation. We show that GA triggers a rapid and marked decrease in the kinase activity of the cyclin E/cdk2 complex coupled with a decline in both total and cdk2-associated cyclin E. In transient transfection experiments, inhibition of cyclin E expression by GA was correlated with inhibition of the transcriptional activity of the cyclin E gene promoter. Inhibition of cdk4 activity by GA was observed 3 hr after addition of the drug to late G(1) cells but not after a short (1 hr) exposure, as revealed by the phosphorylation of Rb on the Ser(780) residue. In human cancer-derived cell lines expressing or not a functional Rb protein, GA blocked proliferation and inhibited the transcriptional activity of the cyclin E gene promoter. In these cell lines, the antiproliferative effect of GA was not limited to the G(1) phase, suggesting the existence of multiple cellular targets of the drug.
Synthesis of gold nanoparticles by laser ablation of an Au foil inside and outside ionic liquids (2011)

Stable gold nanoparticles (AuNPs) were prepared by simple laser ablation of an Au foil placed inside or outside four ionic liquids (ILs), without the addition of any external chemical reagent. Irregular spherical AuNPs with a diameter range of 5 to 20 nm were produced after laser ablation of an Au foil located inside or outside the ILs 1-n-butyl-3-methylimidazolium tetrafluoroborate (BMI·BF4), 1-n-butyl-3-methylimidazolium hexafluorophosphate (BMI·PF6) and 1-(3-cyanopropyl)-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ((BCN)MI·NTf2). Additionally, whereas laser ablation inside the IL 1-n-butyl-3-methylimidazolium dicyanamide BMI·N(CN)2 produced flower-like shaped nanoparticles of about 50 nm in size, ablation outside this IL presented similar results to the others ILs studied, as determined by TEM and UV-Vis. The size and shape of the prepared NPs were related to where NP nucleation and growth occurred, i.e., at the IL surface or within the IL. Indeed, the chemical composition of the IL/air interface and surface ion orientation played important roles in the stabilization of the AuNPs formed by laser ablation outside the ILs.
Performance analysis of intervehicle Communication for Collaborative Traffic Applications (2007)

In the past years, though communication became more and more available and efficient (GPRS, UMTS, Win...), very few traffic applications have been implemented in the real life, all of them using a central server (V2C). Cooperative systems using inter-vehicular communication (V2V) represent the next step, but the deployment roadmap remains unclear, even though safety is strongly pushed. This paper aims at presenting current integration and testing work performed at the LaRA lab for inter-vehicular communication. From the characterization of communication performance, we analyze the suitability of a set of applications. Our aim is to show what kind of application can be deployed with current hardware and software.
AUTOMATIC GENERATION CONTROL OF INTERCONNECTED POWER SYSTEM USING ANN TECHNIQUE BASED ON µ-SYNTHESIS (2004)

This paper presents a nonlinear Artificial Neural Networks (ANN) controller based on µ–synthesis for Automatic Generation Control (AGC) of power systems. Power systems such as other industrial plants have some uncertainties and deviations due to multivariable operating conditions and load changes. For this reason, in the design of ANN controller the idea of µ synthesis theory is used. The motivation of using the µ–based robust controller for training the proposed controller is to take the large parametric uncertainties and modeling error into account in such a way that both the stability of the overall system and good performance have been achieved for all admissible uncertainties. The simulation results on a twoarea power system show that the proposed ANN controller is effective and gives good dynamic responses even in the presence of Generation Rate Constraints (GRC). In addition, it is superior to the conventional PI and µ–based robust controllers. K e y w o r d s: AGC, Power System Control, ANN, µ-synthesis, Robust Control. 1
Antenatal Diagnosis of Alobar Holoprosencephaly (2014)

A twenty-year-old second gravida presented to the department of radiodiagnosis for routine obstetric ultrasound examination. Ultrasonography revealed a live fetus of 17 weeks with absent falx, fused thalami, monoventricle, proboscis, and cyclopia. Fetal MRI was performed and the findings were confirmed. Even though ultrasonography is diagnostic in the detection of fetal anomalies, MRI plays a vital role due to its multiplanar capability and excellent soft tissue resolution. The importance of presenting this classical case of alobar holoprosencephaly is to sensitize the clinicians and radiologists to the imaging manifestations of holoprosencephaly and to stress the importance of early diagnosis. If diagnosed in utero at an early stage of pregnancy, termination can be performed and maternal psychological trauma of bearing a deformed fetus can be avoided.
PLASTICITY OF THE SPINAL NEURAL CIRCUITRY AFTER INJURY (2004)

Motor function is severely disrupted following spinal cord injury (SCI). The spinal circuitry, however, exhibits a great degree of automaticity and plasticity after an injury. Automaticity implies that the spinal circuits have some capacity to perform complex motor tasks following the disruption of supraspinal input, and evidence for plasticity suggests that biochemical changes at the cellular level in the spinal cord can be induced in an activity-dependent manner that correlates with sensorimotor recovery. These characteristics should be strongly considered as advantageous in developing therapeutic strategies to assist in the recovery of locomotor function following SCI. Rehabilitative efforts combining locomotor training pharmacological means and/or spinal cord electrical stimulation paradigms will most likely result in more effective methods of recovery than using only one intervention.
Understanding the effect of cellular structures on mechanical behavior of additively manufactured 316L stainless steel (2021)

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Multi-privacy biometric protection scheme using ensemble systems (2015)

Biometric systems use personal biological or behavioural traits that can uniquely characterise an individual but this uniqueness property also becomes its potential weakness when the template characterising a biometric trait is stolen or compromised. To this end, we consider two strategies to improving biometric template protection and performance, namely, (1) using multiple privacy schemes and (2) using multiple matching algorithms. While multiple privacy schemes can improve the security of a biometric system by protecting its template; using multiple matching algorithms or similarly, multiple biometric traits along with their respective matching algorithms, can improve the system performance due to reduced intra-class variability. The above two strategies lead to a novel, ensemble system that is derived from multiple privacy schemes. Our findings suggest that, under the worst-case scenario evaluation where the key or keys protecting the template are stolen, multi-privacy protection scheme can outperform a single protection scheme as well as the baseline biometric system without template protection.
Development of Methods for Studying the Differentiation of Human Mesenchymal Stem Cells Under Cyclic Compressive Strain (2011)

Human mesenchymal stem cells (hMSC) have numerous potential advantages over terminally differentiated cells and embryonic stem cells for use in tissue engineering applications. The aims of this study were to develop methods to test the hypothesis that hMSC could be differentiated using cyclic compressive strain alone. hMSC were successfully isolated, purified using D7-FIB antibody, cloned, and characterized. The cells were subsequently analyzed using fluorescence-activated cell sorting using a panel of antibodies and differentiation into multiple cell lineages. D7FIB-positive cells were then seeded into collagen-alginate scaffolds and subjected to 10% or 15% cyclic compressive strain for 4 out of 24 hours for up to 21 days in a bespoke servo-assisted displacement-controlled device. Cells were analyzed using adenosine triphosphate assay to determine cell number, live-dead cell assay, and quantitative real-time polymerase chain reaction at 7 and 21 days. Cloned D7-FIB-positive hMSCs showed evidence of differentiation to an osteogenic lineage under 10% cyclic compressive strain alone (core binding factor alpha 1 (CBFA-1) was significantly upregulated at 7 and 21 days by a factor of 18.3 and 32.2, respectively) and to an osteo-chondrogenic lineage under 15% cyclic compressive strain alone (increased expression of CBFA-1, Sox9, and aggrecan). A combination of a composite viscoelastic scaffold and controlled cyclic compressive strain may be useful for study of the differentiation of MSC.
Application of a Nested Polymerase Chain Reaction Assay to Detect<i>Mycoplasma Hyopneumoniae</i>from Nasal Swabs (1999)

The porcine respiratory disease complex (PRDC) is an increasingly important cause of decreased swine productivity and is characterized by slow growth, decreased feed efficiency, anorexia, cough, and dyspnea. Mycoplasma hyopneumoniae is among the most prevalent and important infectious agents associated with PRDC. Understanding of mycoplasmal pneumonia has been hindered by inadequate diagnostic methods. Many of the currently available tests are relatively insensitive or nonspecific when used in a diagnostic laboratory setting or are too costly or difficult for routine diagnostic use. Several polymerase chain reaction (PCR) assays have been described, but they are not sensitive enough to detect the microorganisms in live pigs, from either nasal or tracheal swabs. A nested PCR using 2 species-specific sets of primers from the 16S ribosomal DNA gave positive results with as little as 80 microorganisms and did not cross-react with other mycoplasma species or with other microorganisms commonly found in the respiratory tract of pigs. This assay was better suited for detection of M. hyopneumoniae from nasal swabs than was conventional PCR. Nasal swab samples were taken at different time periods following experimental challenge of 10 susceptible pigs. Only 2 of the 55 swabs examined gave a positive result with conventional PCR, whereas 30 of the 55 swabs gave a positive result using the nested PCR. Twenty of 40 (50%) nasal swabs from pigs experiencing a respiratory disease outbreak where M. hyopneumoniae had been diagnosed also gave a positive result with the nested PCR. To confirm that the amplified product was specific, 4 nested PCR products were purified, sequences were determined and aligned, and they were confirmed to be from M. hyopneumoniae.
Wiener solution for the broadband Griffiths-Jim beamformers (1990)

The problem of finding the Weiner filters for a wideband adaptive beamformer is treated. Explicit expressions are given for the filters and the error power spectrum in the frequency domain. The expressions are simple to program and make it possible to investigate superresolution for wideband signals and to determine sufficient lengths of finite impulse response filters in adaptive arrays. The Griffiths-Jim (1982) structure implies that the ordinary LMS algorithm can be used without constraints.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
On an unusual azimuthal orientational relationship in the system gallium nitride layer on spinel substrate (2000)

Possible types of orientational relationships for hexagonal and cubic gallium nitride layers on aluminum-magnesium spinel substrates with various crystallographic orientations have been determined as a result of the theoretical and the experimental studies of this system. Most of the experimental data and the data obtained in the present study are consistent with the theoretical considerations. The causes of some apparent inconsistencies are discussed.
Introduction (2010)

This book explores the limits of the idea of 'neo-colonialism' - the idea that in the period immediately after independence Malaya/Malaysia enjoyed only a 'pseudo-independence', largely because of the entrenched and dominant position of British business interests allied to indigenous elites. The author argues that, although British business did indeed have a strong position in Malaysia in this period, Malaysian politicians and administrators were able to utilise British business, which was relatively weak vis-a-vis the Malaysian state, for their own ends, at the same time as indigenous businesses and foreign, non-British competitors were gathering strength. In addition, despite the commitment of both Conservative and Labour governments in the UK to preserving British influence worldwide through the Commonwealth relationship, British firms in Malaysia received only limited support from the British post-imperial state.