gebhart/patrepeval huggingface dataset:
Evaluation of docetaxel in previously untreated extensive-stage small cell lung cancer: a Southwest Oncology Group phase II trial. (1999)

Docetaxel, at a dose of 100 mg/m2, is an active agent in the treatment of small cell lung cancer. Reversible neutropenia is the most common toxicity associated with this treatment. The overall survival (9 months) with this agent is comparable to that reported with other new chemotherapeutic agents in small cell lung cancer and warrants additional evaluation of docetaxel in combination therapy.
Calculating time-to-contact using real-time quantized optical flow (1995)

Despite many recent advances in optical flow research, many robotic vision researchers are frustrated by an inability to obtain reliable optical flow estimates in real-world conditions to apply to real-world tasks. Recently it has been demonstrated that robust, real-time optical flow is possible using standard computing hardware [C94j. One limitation of this correlation-based algorithm is that it does not give truly real-valued image velocity measurements. Therefore, it is not obvious that it can be used for a wide range of robotic vision tasks. One particular application for optical flow is time-to-contact: based on the equations for the expansion of the optical flow field it is possible to compute the number of frames remaining before contact with an observed object. Although the individual motion measurements of this algorithm are of limited precision, they can be combined to produce remarkably accurate time-to-contact measurements, which can be produced in real-time on standard computing hardware. 2
Trapping force on a finite-sized particle in a dielectrophoretic cage (2005)

The point dipole (PD) model is routinely used for estimating the dielectrophoretic (DEP) force acting on a particle placed in the nonuniform electric fields of dielectrophoresis devices, such as square cages. We show that if the particle size is much smaller than the dielectrophoretic cage size, the PD model accurately approximates the actual DEP force, computed numerically using the Maxwell stress tensor method. However, when the two sizes are comparable, the actual DEP force differs significantly in both magnitude and direction from that given by the PD model.
Mechanisms of toxicity of hepsulfam in human tumor cell lines. (1990)

1,7-Heptanediol disulfamate (hepsulfam, NSC 329680) is a new anti-cancer agent which is currently undergoing phase I clinical trials. The mechanism of action of this compound is not clear at this time. We have recently shown that hepsulfam was more toxic to L1210 leukemia cells than was busulfan. Consistent with the difference in toxicity, we found that hepsulfam induced DNA interstrand cross-links in L1210 mouse leukemia cells, whereas busulfan did not. In the present study, we have found that hepsulfam was more cytotoxic to two human leukemia cell lines (HL-60 and K562) and to two human colon carcinoma cell lines (BE and HT-29) than was busulfan. As in L1210 cells, hepsulfam induced a higher level of DNA interstrand cross-links than busulfan. Both compounds induced DNA-protein cross-links. Hepsulfam was also more cytotoxic to the human leukemia cell lines when the concentrations were reduced 10-fold and the duration of drug exposure was increased to 12-h This more accurately reflects the drug exposures that human leukemia cells may encounter in vivo. Under these 12-h drug exposures, hepsulfam was still able to form DNA interstrand and DNA-protein cross-links, whereas busulfan was only able to form DNA-protein cross-links. These results show that busulfan and hepsulfam react with DNA differently and that hepsulfam is a more potent cytotoxic agent.
A robust motion detection and estimation filter for video signals (2002)

The problem of detecting areas of motion in video sequences and estimating parameters such as speed, direction and dynamics is addressed in many applications of image processing such as video surveillance, object tracking, image stream compression or autonomous navigation systems. Real world computer vision highly depends on reliable, robust systems for recognition of motion cues to make accurate high-level decisions about its surroundings. In this paper, we present a simple, yet high performance low-level filter for motion detection and estimation in digitized video signals. The algorithm is based on constant characteristics of a common, 2-frame interlaced video signal, yet its applicability to generically acquired image sequences is shown as well. In general, our approach presents a computationally low-cost solution to motion estimation application and compares very well to existing approaches due to its robustness towards environmental changes. A simple application of motion parameter estimation based on a pedestrian surveillance application is illustrated.
Efficient organic light emitting diodes and photodetectors (2002)

Summary form only given. A discussion of several approaches of employing organic semiconductors to achieve high performance devices is be the focus of this presentation. For example, we discuss means for obtaining extremely high efficiency organic light emitting devices (OLED) for displays, and organic photodetectors for power conversion and other detection applications, by effectively confining and capturing molecular excited states by appropriate and precision insertion of energy barriers in these devices. The first device to be discussed is an electrophosphorescent OLED. We show that by employing metallorganic phosphor molecules based on Pt or Ir, nearly 100% internal electroluminescent efficiency can be achieved. Using this approach, we have succeeded in demonstrating very high efficiency electrophosphorescent OLED emission in the red, green and blue spectral regions. Our most efficient devices demonstrated thus far are based on the green phosphor, (ppy)/sub 2/Ir(acac), with a maximum external quantum efficiency of 19/spl plusmn/1%, and luminous power efficiency of 60/spl plusmn/51 m/W.
Characterization of a Gene Cluster of<i>Staphylococcus warneri</i>ISK-1 Encoding the Biosynthesis of and Immunity to the Lantibiotic, Nukacin ISK-1 (2004)

We characterized a gene cluster in a plasmid designated pPI-1 of Staphylococcus warneri ISK-1 encoding the biosynthesis of and immunity to the lacticin-481 type lantibiotic, nukacin ISK-1. The DNA sequence suggested that the nukacin ISK-1 gene cluster consists of at least six genes, nukA (a structural gene), -M, -T, -F, -E, -G, and two open reading frames, ORF1 and ORF7. NukM and NukT were predicted to be involved in post-translational modification and secretion of nukacin ISK-1 respectively. NukF, -E, and -G were predicted to form a membrane complex which contributes to self-protection from nukacin ISK-1. Transcriptional analyses revealed that nukM through ORF7 comprises an operon, and that ORF1 is transcribed independently from downstream of nukA. The transcriptional levels of the nukA and nukM genes were enhanced by osmotic stress. The expression level of the nukA transcript was scarcely enhanced by nukacin ISK-1, suggesting that expression is not under the control of the autoregulatory circuit.
Efficient high-speed CMOS design by layout based schematic method (2002)

As the diffusion area and the wire capacitance worsen the circuit performance in very high speed CMOS design, the results between schematic and layout differ from each other because of missing parasitic components in the schematic. We address a layout based schematic (LBS) method for high speed CMOS cell design. In our method, we introduce different types of MOS transistors and a wire capacitance estimation method, based on layout knowledge. The simulation results at very high speed show that the difference between LBS and real circuit layout is much smaller, less than 3 percent in rise time, compared to the difference in the worst case up to 65 percent in original schematic. The result of LBS is reliable and easy to be optimized during the schematic procedure. It will reduce the design time and cost in high speed circuit design. We also believe that the LBS is more convenient to be translated into the real layout than the original schematic.
Evaluation of the Abbott LCx Ligase Chain Reaction Assay for Detection of <i>Chlamydia trachomatis</i> and <i>Neisseria gonorrhoeae</i> in Urine and Genital Swab Specimens from a Sexually Transmitted Disease Clinic Population (1998)

The Abbott LCx ligase chain reaction (LCR) assay for the simultaneous detection of Chlamydia trachomatis and Neisseria gonorrhoeae was evaluated by using swab and urine specimens from 562 patients. C. trachomatis results by LCR were compared to those by the Gen-Probe PACE 2 assay, whereas N. gonorrhoeae results by LCR were compared to those by culture. The Gen-Probe and LCR assays were performed according to the manufacturers' instructions. Gram-negative diplococci growing on modified Thayer-Martin medium were confirmed as N. gonorrhoeae by the GonoGen II assay. Supplemental data analysis was performed by major outer membrane protein PCR for C. trachomatis and probes for pilin gene detection for N. gonorrhoeae. A true-positive result for each pathogen was defined as a positive result for all three or two of three assays. Overall agreement among the six assays was 94.8%. C. trachomatis prevalence was 16.2%; N. gonorrhoeae prevalence was 5.5%. The overall sensitivity and specificity, respectively, for each test (after supplemental data analysis) were as follows: for C. trachomatis, Gen-Probe, 65.9 and 100%; LCR on urine, 90.1 and 100%; LCR on swab specimens, 96.7 and 100%; and for N. gonorrhoeae, culture, 80.6 and 100%; LCR on urine, 93.5 and 99.8%; and LCR on swab specimens, 96.8 and 100%. For women, the N. gonorrhoeae culture was very insensitive compared to its performance in men (58.3 versus 94.7%, respectively). For C. trachomatis, the Gen-Probe assay's sensitivity was lower for men than for women (62.3 versus 71.1%, respectively). The sensitivity for C. trachomatis detection by LCR on urethral and cervical swab specimens was 96.2 and 97.4% for men and women, respectively. For men, swab results were slightly better than urine results for both pathogens (sensitivity for C. trachomatis in swab and urine specimens, 96.2 and 92.5%, respectively; sensitivity for N. gonorrhoeae in swab and urine specimens, 100 and 94.7%, respectively), while for women, cervical swabs were superior in sensitivity to urine samples for detecting C. trachomatis (swab, 97.4%; urine, 81.6%) and equivalent for N. gonorrhoeae (swab, 92.3%; urine, 91.6%). The LCx LCR appears to be both sensitive and specific for the detection of C. trachomatis and N. gonorrhoeae when performed on urine or genital swab samples. Swab samples had better sensitivity than urine samples for the detection of both pathogens.
Phase-shifted distributed feedback laser with linearly chirped grating for narrow linewidth and high-power operation (1991)

Phase-shifted distributed feedback laser with linearly chirped grating (PS-CG-DFB) was analyzed. The field distribution, threshold gain difference between the lasing mode and the next lowest threshold gain mode, linewidth of the lasing mode, and output power of PS-CG-DFB were self-consistently calculated under different injection levels. It is found that the lasing mode pattern and the carrier concentration distribution are ‘‘locked’’ at high injection level due to the strong interaction between carriers and photons. The chirped grating compensates the spatial hole burning effect to the mode stability and makes the mode stable in the whole injection region.
A Query-oriented XML Fragment Search Approach on A Relational Database System (2010)

Abstract: In this paper, we propose a query-oriented fragment search approach for efficient and effective XML search engines on relational database systems. Conventional approaches for XML fragment search have only considered statistics of XML documents stored in a database system to rank a search result. As a result, almost all XML fragment search engines have attained negative results in the research field of information retrieval (IR). To cope with this problem, considering not only statistics in the database system but also ones extracted from a query helps to improve retrieval accuracy of XML fragment search engines; however, it is also faced with a problem related with their efficiencies. Therefore, we have to devise ways of achieving both highly-relevant search results and efficient query processing. We implemented our XML search engine adopting the query-oriented fragment search approach, and found that it allows users to search XML fragments more accurately and effectively than conventional ones on our XML search engine.
Rechargeable Ca-Ion Batteries: A New Energy Storage System (2015)

As new uses for larger scale energy storage systems are realized, new chemistries that are less expensive or have higher energy density are needed. While lithium-ion systems have been well studied, the availability of new energy storage chemistries opens up the possibilities for more diverse strategies and uses. One potential path to achieving this goal is to explore chemistries where a multivalent ion such as Ca2+ or Mg2+ is the active species. Herein, we demonstrate this concept for a Ca-ion system utilizing manganese hexacyanoferrate (MFCN) as the cathode to intercalate Ca reversibly in a dry nonaqueous electrolyte. Through characterization via X-ray absorption near-edge spectroscopy, it is determined that only the manganese changes oxidation state during cycling with Ca. X-ray diffraction indicates the MFCN maintains its crystallinity during cycling, with only minor structural changes associated with expansion and contraction. Furthermore, we have demonstrated the first rechargeable Ca-ion battery utilizing MFCN as the cathode and elemental tin as the anode.
Human γ-Glutamyl Transpeptidase Mutants Involving Conserved Aspartate Residues and the Unique Cysteine Residue of the Light Subunit (1995)

Mutant human gamma-glutamyl transpeptidases with amino acid substitutions on the light subunit at the Asp residues conserved among several species, and at the unique cysteine residue (Cys-454), were prepared and expressed in a baculovirus insect cell system. Replacement of Asp-423 by Ala or Glu led to major loss of enzyme activity, consistent with the conclusion that Asp-423 is essential for activity. A mutant in which Cys-454 was replaced by Ala was fully active, indicating that the unique light subunit thiol is not required for catalysis. Kinetic analysis of the hydrolysis reaction of L-gamma-glutamyl-p-nitroanilide indicated that the decreased activity of Asp-423 mutants is the consequence of an extremely high substrate Km value, which is more than a 1000-fold greater than that for the wild-type enzyme, whereas the Vmax is decreased only less than 90-fold. The results suggest that Asp-423, and to a lesser extent Asp-422, interact electrostatically with the alpha-amino group of the gamma-glutamyl donor substrate. Although further studies are required to evaluate the possibility that the reaction involves function of a charge (or proton) relay system, the present work suggests that the gamma-glutamyl moiety of the substrate binds electrostatically to specific groups on the enzyme; this facilitates gamma-glutamyl enzyme formation.
People who cause accidents should pay for victims' care. (1997)

body, has hit on an idea which it claims could recoup an estimated ?120m ($180m) for the NHS making those who cause acci dents pay for their victims' care. The commission says that there is a strong case for the reform, which would in practice draw the extra funds from insur ers. Media attention focused mainly on the prospects of motorists paying, but the paper sees the reform as applying to all types of accident in which the victim recovers damages. The full cost of accidents to the NHS
Impact of Increased Technology Use on the Free-time Choices of Fifth and Seventh Grade Students in a Southern School District (2009)

The study sought to determine if increased technology use affects the free-time choices of students. While technology options have grown exponentially, time remains a fixed commodity. Therefore, it is suggested that students who increasingly use technology must draw time from more traditional childhood activities. Students' free-time activities were examined to document discernable patterns among the activities valued by students who use technology extensively and the activities valued by students who use technology less frequently. Study participants were fifth and seventh grade students in a semi-rural suburban county in the southeastern United States. The data collection instrument was a selfreporting survey in which students were asked to specify their relative interest in six traditional activities in comparison to specific technology-based alternatives. Students were also asked to estimate the number of minutes per week they spent on traditional and technology-related activities. Based on their time estimates, high and low quartiles of technology use were established. The forced-choice responses of students in the upper quartile of technology use were compared to the forced-choice responses of students in the lower quartile of technology use to determine if there were differences in their expressed preferences for the six traditional activities included in the study. Although findings revealed that students in the upper quartile of technology use were less interested in all six traditional activities studied than were students in the lower quartile of technology use, reading for fun, supervised activities, outdoor activities, and having a hobby were activities more readily relinquished than were spending time with family and playing with friends, indicating their relative value among the two groups. As students abandon traditional childhood activities to pursue technology-driven options, adults who are concerned about childhood development might explore alternative means for obtaining the benefits those six activities once provided. Recommendations are made for replicating the study among different populations. Although gender and grade level were two variables that were examined in this study, it would be beneficial to determine if findings would be similar among students with more or less access to technology, with divergent socio-economic means, and from diverse ethnic backgrounds.
Systematic hypermedia application design with OOHDM (1996)

Article Free Access Share on Systematic hypermedia application design with OOHDM Authors: Daniel Schwabe Departamento de Informática, Pontifícia Universidade Católica, R. Marquêes de São Vicente, 225, Rio de Janeiro, RJ 22453-900, Brazil Departamento de Informática, Pontifícia Universidade Católica, R. Marquêes de São Vicente, 225, Rio de Janeiro, RJ 22453-900, BrazilView Profile , Gustavo Rossi Departamento de Informática, Pontifícia Universidade Católica, R. Marquêes de São Vicente, 225, Rio de Janeiro, RJ 22453-900, Brazil and LIFIA, F. Cs. Exactas-UNLP, and CONICET, Argentina Departamento de Informática, Pontifícia Universidade Católica, R. Marquêes de São Vicente, 225, Rio de Janeiro, RJ 22453-900, Brazil and LIFIA, F. Cs. Exactas-UNLP, and CONICET, ArgentinaView Profile , Simone D. J. Barbosa Departamento de Informática, Pontifícia Universidade Católica, R. Marquêes de São Vicente, 225, Rio de Janeiro, RJ 22453-900, Brazil Departamento de Informática, Pontifícia Universidade Católica, R. Marquêes de São Vicente, 225, Rio de Janeiro, RJ 22453-900, BrazilView Profile Authors Info & Claims HYPERTEXT '96: Proceedings of the the seventh ACM conference on HypertextMarch 1996 Pages 116–128https://doi.org/10.1145/234828.234840Online:01 March 1996Publication History 207citation1,522DownloadsMetricsTotal Citations207Total Downloads1,522Last 12 Months25Last 6 weeks8 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy (2009)

We examined the effects of 48 h bilateral nephrectomy on plasma and cardiac tissue expression of angiotensin-(1-12) [ANG-(1-12)], ANG I, and ANG II in adult Wistar-Kyoto rats to evaluate functional changes induced by removing renal renin. The goal was to expand the evidence of ANG-(1-12) being an alternate renin-independent, angiotensin-forming substrate. Nephrectomy yielded divergent effects on circulating and cardiac angiotensins. Significant decreases in plasma ANG-(1-12), ANG I, and ANG II levels postnephrectomy accompanied increases in cardiac ANG-(1-12), ANG I, and ANG II concentrations compared with controls. Plasma ANG-(1-12) decreased 34% following nephrectomy, which accompanied 78 and 66% decreases in plasma ANG I and ANG II, respectively (P < 0.05 vs. controls). Contrastingly, cardiac ANG-(1-12) in anephric rats averaged 276 +/- 24 fmol/mg compared with 144 +/- 20 fmol/mg in controls (P < 0.005). Cardiac ANG I and ANG II values were 300 +/- 15 and 62 +/- 7 fmol/mg, respectively, in anephric rats compared with 172 +/- 8 fmol/mg for ANG I and 42 +/- 4 fmol/mg for ANG II in controls (P < 0.001). Quantitative immunofluorescence revealed significant increases in average grayscale density for cardiac tissue angiotensinogen, ANG I, ANG II, and AT(1) receptors of WKY rats postnephrectomy. Faint staining of cardiac renin, unchanged by nephrectomy, was associated with an 80% decrease in cardiac renin mRNA. These changes were accompanied by significant increases in p47(phox), Rac1, and Nox4 isoform expression. In conclusion, ANG-(1-12) may be a functional precursor for angiotensin peptide formation in the absence of circulating renin.
Tunable pulse repetition-rate multiplication using phase-only line-by-line pulse shaping (2007)

We demonstrate a method for all-optical, tunable pulse repetition-rate multiplication of a mode-locked laser based on spectral line-by-line control. In particular, two-to-five-times repetition-rate multiplication of a 9 GHz source is achieved with very high fidelity.
Camera system for arbitrary viewpoint 3D display system (2005)

We have developed an arbitrary viewpoint 3D display system. This system consists of multiview camera system for 3D data capturing and real-time color autostereoscopic 3D display system. The multiview camera system is based on the image-based rendering technique. To reconstruct a 3D image of a real 3D object, this 3D display system requires many multiview images. Therefore, it is difficult to implement multiview camera system. In order to overcome this problem, we propose the interpolation method to decrease the number of required multiview images. This paper describes multiview camera system to obtain the ray data of real 3D objects for arbitrary viewpoint 3D display system. This camera system consists of 9 CMOS cameras, and their pixels are randomly accessible. Thus, the ray data to reconstruct 3D images of captured real 3D objects can be synthesized from 9 CMOS cameras directly. Each ray data to reconstruct captured real 3D objects is calculated by the FPGA board, and the pixel corresponds to each ray data, which is given by the FPGA board to the PC. Therefore, arbitrary viewpoint 3D display with proposed camera system can display real-time captured 3D objects. As the experimental results, the 3D image of real object is reconstructed.
Molecular Biology of Neuroblastoma (1999)

The molecular biology of neuroblastoma has led to a combined clinical and biologic risk stratification. Future advances may lead to more specific treatment strategies for children with neuroblastoma.