gebhart/patrepeval huggingface dataset:
Multimarker immunohistochemical staining of calgranulins, chloroacetate esterase, and S100 for simultaneous demonstration of inflammatory cells on paraffin sections. (1990)

Mac387 monoclonal antibody (MAb) recognizes two calcium binding, myeloid-associated proteins, now termed calgranulins, expressed at high levels by neutrophils and monocytes. Calgranulins are related to migration inhibitory factor (MIF) and are lost in a few days from monocytes differentiated in vitro. This marker is therefore potentially useful to analyze macrophage heterogeneity and turnover in tissue sections. In this study, we developed an immunohistochemical multimarker technique, including calgranulin demonstration, suitable for analyzing different inflammatory cells on paraffin-embedded material. The technique was carried out in subsequent steps demonstrating (a) naphthol AS-D chloroacetate esterase (CAE); (b) S100 immunoreactivity using a rabbit antibody in peroxidase-antiperoxidase (PAP) staining; and (c) Mac387 immunoreactivity using the alkaline phosphatase-anti-alkaline phosphatase (APAAP) technique. CAE staining was introduced in this method to distinguish Mac387+/CAE- macrophages from Mac387+/CAE+ neutrophils, and Mac387-/CAE+ mast cells. S100 protein is strongly expressed within lymphoid tissues by dendritic accessory cells and was then applied to distinguish these cells from S100-macrophages. We have also verified the possibility of reducing the staining time for this time-consuming procedure by use of microwave irradiation. The technique was applied to a representative variety of normal and pathological samples to assess its usefulness for study of cell heterogeneity. Our results showed the multimarker technique to be highly informative in the study of inflammatory lesions (e.g., rheumatoid arthritis, sarcoid and cat-scratch granulomas, dermathopathic lymphadenopathy), and is of wide potential value as an aid to histopathological diagnosis of several diseases.
Crystal growth kinetics of boron oxide under pressure (1985)

We have measured the crystal growth rate u of B2O3-I in the amorphous phase, as it varied over five orders of magnitude with changes in temperature and pressure. We eliminated the crystal nucleation barrier by seeding the surface of boron oxide glass with crystals. u became measurable only when the pressure exceeded a threshold level near 10 kbar. Using the published thermodynamic information on the B2O3 system and a crude free-energy model for the crystal and glass phases, we account qualitatively for our results with the theory of crystal growth limited by the rate of two-dimensional nucleation of monolayers. The constants for the prefactor, activation energy, activation volume, and ledge tension are determined by fitting. By adjusting the thermodynamic parameters to a set of values that are well within the ranges delineated by their experimental uncertainties, we account quantitatively for the measured growth rates from 300 to 500 °C and from 0 to 30 kbar with the following relation: u(T,P)=(785 m/s)[‖ΔGm‖/(RT)]1/6 ×exp[π×3 Å(420 erg/cm2)2(28 cm3/mole)/(3 kTΔGm)]exp[−10 366 cal/mole/(RT)] ×exp[−P×16 cm3/mole/(RT)]×{1−exp[ΔGm/(RT)]}2/3, with the driving free energy given by ΔGm(T,P)=(13 cm3/mole) [PM(T)−P] and the melting curve given by PM(T)=(T−450 °C)/(42.6 K/kbar). The ‘‘B2O3 crystallization anomaly’’, that crystals have never been observed to grow at atmospheric pressure, is explained, since according to our model, the frequency of two-dimensional nucleation is negligible at all temperatures at pressures less than 10 kbar.
The Status of YATP and Maintenance Energy as Biologically Interpretable Phenomena (1984)

Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly pathogenic HCoVs: severe acute respiratory syndrome coronavirus (SARS-CoV) and ...Read More
Quantum information with continuous variables (2005)

Quantum information is a rapidly advancing area of interdisciplinary research. It may lead to real-world applications for communication and computation unavailable without the exploitation of quantum properties such as nonorthogonality or entanglement. This article reviews the progress in quantum information based on continuous quantum variables, with emphasis on quantum optical implementations in terms of the quadrature amplitudes of the electromagnetic field.
Organo-silica nano-particles used in ultrahigh-pressure liquid chromatography (2002)

A simple one-step process was used to synthesize uniform, spherical organosilica nano-particles containing octadecyl moieties. These nano-particles, having a diameter of 670 nm, were slurry packed into fused-silica capillary tubes of 50 microm internal diameter and tested for use in ultrahigh-pressure liquid chromatography (UHPLC) at inlet pressures of about 50,000 psi (approximately 3,500 bar), providing for the use of HPLC with nano-particle packed columns. The retention characteristics of a column packed with the organo-nano-particles were shown to be stable under acidic (pH < 1) and basic (pH > 11) conditions. Fast analysis times and relatively high separation efficiencies (approximately 500,000 plates m(-1)) were obtained under the conditions used.
Political and Occupational Barriers to the Implementation of Affirmative Action: Administrative, Executive, and Legislative Attitudes toward Representative Bureaucracy (1984)

This article reports the results of a five-state survey of administrators, executives, and legislators from Florida, Iowa, Kentucky, Maine, and Wisconsin. The survey was conducted in 1979 regarding attitudes toward representative bureaucracy/affirmative action and policies in support of improved conditions for ethnic minorities and women. Government elites are divided in their views of representative bureaucracy with more registering disapproval than approval; however, this “opposition” is not supported by demands that less effort be expended on such efforts. Political and occupational characteristics (ideology, party, state, age, seniority, and education) show slight effect. Some evidence exists supporting a self-interest thesis among administrators and a general politicization of the topic.
Fourth-power law clock recovery with prefiltering (2002)

The performance of a clock recovery scheme employing fourth-power law nonlinearity and prefiltering is described. This scheme uses a prefilter centered at 1/4 of the symbol rate and of a bandwidth not greater than 1/8 of the symbol rate. It is found that time jitter due to self-noise can be completely eliminated if the signal is sent only during every other symbol period.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer (2003)

The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within a Japanese population. Fifty-seven women with HPV16-positive cervical cancer were analyzed for E6 sequence variation and its relationship to HLA class II alleles. Compared with local controls (n = 138) and published controls (n = 916), DRB1*1501 and DQB1*0602 frequencies were significantly increased among patients with HPV16 E6 prototype (n = 11). Additionally, DRB1*1502 was positively associated with a particular E6 variant designated D25E (n = 25), although we could not find a significant association between HLA class II alleles and L83V variants (n = 16). Our observations suggest that a specific match between E6 variant proteins and HLA types may contribute to HPV16-related cervical carcinogenesis.
192. Halogen derivatives of dehydro-2-naphthol 1-disulphide (1933)

J. A. C. McClelland and S. Smiles, J. Chem. Soc., 1933, 786 DOI: 10.1039/JR9330000786
Obituary (1962)

Obituary Get access Robert Morris Jones Robert Morris Jones Search for other works by this author on: Oxford Academic PubMed Google Scholar Occupational Medicine, Volume 12, Issue 1, April 1962, Page 31, https://doi.org/10.1093/occmed/12.1.31 Published: 01 April 1962
Subcellular Localization of the Major Pneumococcal Autolysin: A Peculiar Mechanism of Secretion in Escherichia coli (1989)

The major pneumococcal autolysin (N-acetylmuramoyl-L-alanine amidase) has been localized in the cellular envelope of Streptococcus pneumoniae and Escherichia coli by using immunocytochemical labeling on ultrathin sections and whole-mounted cells. Cell fractionation experiments in E. coli confirmed the peripheral localization of the pneumococcal amidase and suggested that this enzyme is weakly bound to the outer face of the cytoplasmic membrane. This interaction does not depend on the presence of choline but represents an intrinsic property of the amidase. The autolysin, that is synthesized without any N-terminal signal sequence (García, P., García, J. L., García, E., and López, R. (1986) Gene (Amst.) 43, 265-272) was not processed during translocation. A new regulatory mechanism that might be specific for bacterial autolysins is discussed.
Nanoconfining affinity materials for pH-mediated protein capture–release (2014)

Based on the nanoconfinement effect, two new affinity materials that have a pH-responsive capture–release ability for proteins were developed.
Haptic touchscreen display for avionics: Demonstrator characterization measurements (2015)

The paper aims to present the implementation of surface haptics feature on the optically bonded touch screen display, 10.4" of size, currently used on the AW169 helicopter; this technology has never been used in avionic environment up to now. A demonstrator has been realized and tested as an intermediate, verification, step to a prototype that will be mounted in the Agusta Westland AW169 helicopter and tested in flight. The demonstrator is at a stage defined as Technology Readiness Level 6: System/subsystem model or prototyping demonstration in a relevant end-to-end environment (ground or space). Prototyping implementations on full-scale realistic problems. Engineering feasibility fully demonstrated in actual system application. The prototype will be a straightforward integration of this demonstrator, whose very satisfactory features will be here reported. The work and tests have been carried out at Redux Labs (Cambridge, UK), who hold multiple surface haptics patents.
On-demand flexible tiered qos scheduling algorithm for ieee 802.16j multi-hop relay networks (2010)

WiMAX is a wireless technology that provides broadband access for services having different QoS requirements and different traffic priorities. Since the QoS demands of different traffic flows vary, it is the responsibility of the medium access control (MAC) layer to schedule the traffic flows and allocate bandwidth such that the QoS requirements of each flow is satisfied. This scenario is even more complex when multi-hop relays are introduced into the network. Nonetheless, the IEEE 802.16j standard does not specify any QoS architectures or scheduling mechanisms. In this paper, we propose an On-Demand Flexible Tiered (ODFT) QoS scheduling algorithm for WiMAX Multi-hop Relay networks to guarantee the QoS demands of various applications by utilizing QoS tiers for the relay network. The ODFT (1) classifies the user requests from various wireless zones based on the zone ID and service flow types, (2) calculate the QoS weights of the service flows, (3) schedule service flows based on the calculated weights, and (4) allocate suitable bandwidth for each service flow type.
The motion of a ship at sea and the consequent motion sickness amongst passengers (1986)

Measurements were made of the motion of a ship, and of the consequent seasickness experienced by passengers. Data are presented for 17 voyages of up to 6 hours duration, involving 4915 passengers. Vertical motion occurred up to 1·0 m s−2 r.m.s. and vomiting incidence of up to nearly 40% was encountered. Both vomiting incidence and illness rating correlated well with root mean square vertical z-axis acceleration. The effect of exposure duration was also investigated, producing suggestions for a combined measure of acceleration and time. Multiple regression analysis with all six axes of motion revealed only a small increase in correlation when all directions of motion in addition to the z-axis were taken into account.
Integrating geometric constraints into reactive leg motion generation (2010)

This paper proposes a reactive leg motion generation method which integrates geometric constraints into its generation process. In order to react given instructions instantaneously or to keep balance against external disturbances, feasible steps must be generated automatically in real-time for safety. In many cases this feasibility has been realized by using predefined steps or admissible stepping regions. However, these predefinitions are often too conservative or valid only in limited situations. The proposed method considers geometric constraints in addition to joint limits during its generation process and it can utilize the ability of the robot to a maximum extent. It can generate feasible walking pattern in real-time by modifying the swing leg motion and the next landing position at each control cycle. The proposed method is validated by experiments using a humanoid robot HRP-2.
I La Galigo by Robert Wilson (2007)

No doubt a reference to Einstein’s Twin Paradox constitutes a seemingly incongruous opening to an appraisal of Robert Wilson’s latest production I La Galigo, inspired by an epic poem from South Sulawesi. However, Einstein is not only the subject of one of Wilson’s most acclaimed productions, but this brief allusion to his theory encapsulates the hypnotic dilation of time intrinsic to Wilson’s theatre. Wilson is known for his ability to transform the stage into a temporal sculpture that renders the presence of time aesthetically tangible through duration and repetition. His unique spatial construction imposes a kinetic logic on objects and the human body to frame motion and open up ‘mental space’ for contemplation in the theatre medium (Wilson, 1997: 81). What ensues for the audience is an atmosphere analogous to the experience implied by the unearthly ‘blood flow’ of Einstein’s clock.
Measurements of serum gamma-seminoprotein and prostate specific antigen evaluated for monitoring carcinoma of the prostate. (1986)

We have compared the concentrations in serum of gamma-seminoprotein (gamma-SM) and prostate specific antigen (PSA), two antigens of prostatic origin that are synthesized independently of prostatic acid phosphatase (PAP, EC 3.1.3.2), to assess their potential in monitoring prostatic cancer. At presentation, 27/30 (90%) patients with metastases had a PSA concentration greater than 10 ng/mL, and 29/30 (97%) a gamma-SM concentration greater than 10 ng/mL; 21/61 (34%) with disease but without metastases had an abnormal content of PSA, and 23/61 (38%) an abnormal gamma-SM. Concentrations of PSA and gamma-SM were significantly correlated (r = 0.68, p less than 0.001). In 20 patients without metastases followed longitudinally, the median concentrations of gamma-SM, PSA, and PAP in the 13 patients who developed bony metastases or showed signs of local spreading of the tumor were 58 ng/mL, 34 ng/mL, and 2.1 U/L, respectively. The corresponding median values in the seven patients who remained clinically stable were 2.5 and 3.9 ng/mL, and 2.3 U/L. We conclude that either PSA or gamma-SM can warn of disease progression when PAP activities are still within normal limits.
Sequence‐specific binding by <i>Aspergillus nidulans</i> AflR, a C<sub>6</sub> zinc cluster protein regulating mycotoxin biosynthesis (1998)

The Aspergillus nidulans aflR gene is found within a 60 kb gene cluster that includes approximately 24 other genes that putatively function in the production of the aflatoxin-related mycotoxin sterigmatocystin. Previous work showed that AflR is a C6 zinc binuclear cluster protein that is conserved across Aspergillus spp. and functions as a pathway-specific transcription factor in activating expression of other cluster genes. In this report, we demonstrate that A. nidulans AflR (AnAflR) is a 45kDa protein that binds to the palindromic sequence 5'-TCG(N5)CGA-3' found in the promoter regions of several aflatoxin and sterigmatocystin cluster genes (stc genes). The in vivo relevance of this AnAflR binding site was assessed by examining the contribution of the three TCG(N5)CGA elements in the 1.1 kb promoter region of stcU using gene fusions with the bacterial uidA gene encoding beta-glucuronidase (GUS). By mutating one, two or all three of the AnAflR-binding elements and examining GUS activity in wild-type aflR or delta aflR A. nidulans strains, we found that stc gene activation required both AnAflR and at least one TCG(N5)CGA AflR binding site.
Law in Cyberspace (Tutorial). (1996)

Shock wave attenuation rate and formation of central uplifts are not precisely constrained for moderately sized complex impact structures. The distribution of shock metamorphism in drilled basement rocks from the 10.5-kilometer-diameter Bosumtwi crater, and results of numerical modeling of inelastic rock deformation and modification processes during uplift, constrained with petrographic data, allowed reconstruction of the pre-impact position of the drilled rocks and revealed a shock attenuation by approximately 5 gigapascals in the uppermost 200 meters of the central uplift. The proportion of shocked quartz grains and the average number of planar deformation feature sets per grain provide a sensitive indication of minor changes in shock pressure. The results further imply that for moderately sized craters the rise of the central uplift is dominated by brittle failure.
In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain (1998)

The adult mammalian forebrain contains a population of multipotential neural stem cells in the subependyma of the lateral ventricles whose progeny are the constitutively proliferating cells, which divide actively throughout life. The adult mammalian brain is ideal for examining the kinetics of the stem cells due to their strict spatial localization and the limited and discrete type of progeny generated (constitutively proliferating cells). Clonal lineage analyses 6 days after retrovirus infection revealed that under baseline conditions 60% of the constitutively proliferating cells undergo cell death, 25% migrate to the olfactory bulb and 15% remain confined to the lateral ventricle subependyma (where they reside for approximately 15 days). Analysis of single cell clones 31 days after retroviral infection revealed that the stem cell divides asymmetrically to self-renew and give rise to constitutively proliferating cells. Following repopulation of the depleted subependyma the average clone size is 2.8 times larger than control, yet the absolute number of cells migrating to the olfactory bulb is maintained and the stem cell retains its asymmetric mode of division. The number of neural stem cells in the adult forebrain 33 days after repopulation of the subependyma was estimated using bromodeoxyuridine labeling of subepenydmal cells. There were calculated to be 1200-1300 cells between the rostral corpus callosum and rostral anterior commissure; these data support a lineage model similar to those based on stem cell behavior in other tissue types.
The 9‐point hedonic scale and hedonic ranking in food science: some reappraisals and alternatives (2014)

The 9-point hedonic scale has been used routinely in food science, the same way for 60 years. Now, with advances in technology, data from the scale are being used for more and more complex programs for statistical analysis and modeling. Accordingly, it is worth reconsidering the presentation protocols and the analyses associated with the scale, as well as some alternatives. How the brain generates numbers and the types of numbers it generates has relevance for the choice of measurement protocols. There are alternatives to the generally used serial monadic protocol, which can be more suitable. Traditionally, the 'words' on the 9-point hedonic scale are reassigned as 'numbers', while other '9-point hedonic scales' are purely numerical; the two are not interchangeable. Parametric statistical analysis of scaling data is examined critically and alternatives discussed. The potential of a promising alternative to scaling itself, simple ranking with a hedonic R-Index signal detection analysis, is explored in comparison with the 9-point hedonic scale.
Differential oxidative stress and DNA damage in rat brain regions and blood following chronic arsenic exposure (2008)

Chronic arsenic poisoning caused by contaminated drinking water is a wide spread and worldwide problem particularly in India and Bangladesh. One of the possible mechanisms suggested for arsenic toxicity is the generation of reactive oxygen species (ROS). The present study was planned 1) to evaluate if chronic exposure to arsenic leads to oxidative stress in blood and brain - parts of male Wistar rats and 2) to evaluate which brain region of the exposed animals was more sensitive to oxidative injury. Male Wistar rats were exposed to arsenic (50A ppm sodium arsenite in drinking water) for 10A months. The brain was dissected into five major parts, pons medulla, corpus striatum, cortex, hippocampus, and cerebellum. A number of biochemical variables indicative of oxidative stress were studied in blood and different brain regions. Single-strand DNA damage using comet assay was also assessed in lymphocytes. We observed a significant increase in blood and brain ROS levels accompanied by the depletion of GSH/GSSG ratio and glucose-6-phosphate dehydrogenase (G6PD) activity in different brain regions of arsenic-exposed rats. Chronic arsenic exposure also caused significant single-strand DNA damage in lymphocytes as depicted by comet with a tail in arsenic-exposed cells compared with the control cells. On the basis of results, we concluded that the cortex region of the brain was more sensitive to oxidative injury compared with the other regions studied. The present study, thus, leads us to suggest that arsenic induces differential oxidative stress in brain regions with cortex followed by hippocampus and causes single-strand DNA damage in lymphocytes.
Human Exposure to RF, Microwave, and Millimeter-Wave Electromagnetic Radiation [Health Effects] (2016)

Mobile phones and other wireless devices and systems rely on RF or microwave radiation to function. They use RF or microwave radiation to send and receive text and voice messages, along with many other kinds of data. In addition to RF and microwaves, millimeter and terahertz waves are increasingly enlisted to support the rally toward ubiquitous, round-the-clock wireless connectivity. For the first time in its history, a ubiquitous source of RF radiation is being placed directly next to the heads (and bodies) of a large portion of the human race; in fact, the percentage of all people being exposed to RF electromagnetic radiation is rapidly approaching the percentage exposed to polluted air. the author discusses research and warnings about the health risks of human exposure to RF, microwave, and millimeter-wave electromagnetic radiation.
Power quality conditioning based on space vector transformation (2005)

The paper presents a novel solution for power quality conditioning exploiting the capabilities of the DC/AC converter of a system that has been developed to generate electric power by utilizing alternative, renewable and waste energies, pointing out that the solution can also be applied in other fields of power electronic energy conversion. The solution of power quality conditioning is based on the application of space vector theory, using an algorithm easy to implement. The theoretical analysis is confirmed by computer simulation results.