gebhart/patrepeval huggingface dataset:
Loss of RB compromises specific heterochromatin modifications and modulates HP1α dynamics (2007)

Heterochromatin domains are important for gene silencing, centromere organization, and genomic stability. These genomic domains are marked with specific histone modifications, heterochromatin protein 1 (HP1) binding and DNA methylation. The retinoblastoma tumor suppressor, RB mediates transcriptional repression and functionally interacts with a number of factors that are involved in heterochromatin biology including HP1, Suv39h1, DNMT1, and components of the SWI/SNF chromatin remodeling complex. To analyze the specific influence of RB loss on chromatin modification, mouse adult fibroblasts (MAFs) derived from Rb(loxP/loxP) mice were utilized to acutely knockout RB. In this setting, target genes of RB are deregulated. Additionally, changes in histone modifications were observed. Specifically, histone H4 lysine 20 trimethylation was absent from heterochromatin domains following loss of RB and there were changes in the relative levels of histone modifications between RB-proficient and deficient cells. While RB loss significantly altered the modifications associated with heterochromatin domains, these domains were readily identified and efficiently mediated the recruitment of HP1alpha. Kinetic analyses of HP1alpha within the heterochromatin domains present in RB-deficient cells indicated that loss of RB retarded HP1alpha dynamics, indicating that HP1alpha is paradoxically more tightly associated with heterochromatin in the absence of RB function. Combined, these analyses demonstrate that loss of RB has global effects on chromatin modifications and dynamics.
Recyclable 3D printing of vitrimer epoxy (2017)

An epoxy ink and its 3D printing method were developed to allow printed parts to be recycled and reprinted.
Efficient memory integrity verification and encryption for secure processors (2004)

Secure processors enable new sets of applications such as commercial grid computing, software copy-protection, and secure mobile agents by providing security from both physical and software attacks.This paper proposes new hardware mechanisms for memory integrity verification and encryption, which are two key primitives required in singlechip secure processors.The integrity verification mechanism offers significant performance advantages over existing ones when the checks are infrequent as in grid computing applications.The encryption mechanism improves the performance in all cases.
Hybrid avatars (2016)

Virtual reality (VR) and augmented reality (AR) technologies are quickly making their way into people's everyday lives. Typically, these technologies are used separately to create either plain VR or AR applications rather than harnessing the possibilities of combining the two. In this position paper, we introduce a novel concept of hybrid avatar that enables avatar-based interactions between VR and AR users visiting the same place both in the real world and its virtual counterpart. We illustrate a generic architecture for implementing hybrid avatar interactions, present our prototype implementation and discuss the implementation related challenges. Main contribution of this paper is to provide new ideas for research on the areas of VR, AR, and hybrid reality.
Increasing the Capacity for Automated Valet Parking Using Variable Spot Width (2020)

Automated vehicles allow to adapt new parking concepts, which have the potential to increase the parking capacity significantly. Thereby, the abilities to assign optimal parking spaces to the vehicles and to perform shunting operations are systematically utilised. In this paper, the typical parking order with spots of constant width is replaced by a loose parking order with variable width. In this way, the width of each individual vehicle can be considered, which leads to an improved utilisation of the available space. Despite this improvement, first simulation studies without shunting operations under realistic conditions did not show the expected results. Therefore, an optimum strategy for shunting operations is deployed. As the optimisation is computationally challenging, a heuristic method is proposed which shows similar results as the optimal solution. A substantial increase in the parking capacity of up to 12% for a commercial parking garage is achieved, where no constructional modifications are necessary.
Independiencia ayer, ¿independencia hoy? (2010)

Durante mas de treinta anos se forjo gracias a numerosas rebeliones como la de los indigenas negros y el mismo movimientos comunero de 1781 la gesta de la independencia contra la dominacion espanola hoy el multiple y diverso pueblo Colombiano continua en resistencia viviendo nuevas formas de colonizacion y dominacion Identificaremos en la presente revista algunos problemas que merecen reflexion hacia procesos de cambio por condiciones de vida digna que posibiliten la autonomia de los pueblos y la definicion de su devenir en beneficio de los diversos pueblos que conforman a Colombia y disminuyendo los servicios hacia los grandes intereses internacionales
Supramolecular Organization of Dye Molecules in Zeolite L Channels: Synthesis, Properties, and Composite Materials (2016)

Sequential insertion of different dyes into the 1D channels of zeolite L (ZL) leads to supramolecular sandwich structures and allows the formation of sophisticated antenna composites for light harvesting, transport, and trapping. The synthesis and properties of dye molecules, host materials, composites, and composites embedded in polymer matrices, including two- and three-color antenna systems, are described. Perylene diimide (PDI) dyes are an important class of chromophores and are of great interest for the synthesis of artificial antenna systems. They are especially well suited to advancing our understanding of the structure-transport relationship in ZL because their core fits tightly through the 12-ring channel opening. The substituents at both ends of the PDIs can be varied to a large extent without influencing their electronic absorption and fluorescence spectra. The intercalation/insertion of 17 PDIs, 2 terrylenes, and 1 quaterrylene into ZL are compared and their interactions with the inner surface of the ZL nanochannels discussed. ZL crystals of about 500 nm in size have been used because they meet the criteria that must be respected for the preparation of antenna composites for light harvesting, transport, and trapping. The photostability of dyes is considerably improved by inserting them into the ZL channels because the guests are protected by being confined. Plugging the channel entrances, so that the guests cannot escape into the environment is a prerequisite for achieving long-term stability of composites embedded in an organic matrix. Successful methods to achieve this goal are described. Finally, the embedding of dye-ZL composites in polymer matrices, while maintaining optical transparency, is reported. These results facilitate the rational design of advanced dye-zeolite composite materials and provide powerful tools for further developing and understanding artificial antenna systems, which are among the most fascinating subjects of current photochemistry and photophysics.
Human Serum Albumin as a &lsquo;Silent Receptor&rsquo; for Drugs and Endogenous Substances (1979)

Most drugs are bound to human serum albumin (HSA) via a few high affinity binding sites and several sites of much lower affinity. There is now increasing evidence that the actual number of high affinity drug-binding sites of HSA is rather small. Thus, each of these binding sites binds several drugs of very different chemical and pharmacological properties with relative high affinity. On the other hand these drug-binding sites can in some cases be very specific and even stereoselective, as demonstrated by the stereospecific binding of drugs to some of these binding sites. The discrepancy between both observations can be explained by the conformational adaptability of the HSA-binding sites.
Evaluation of Characteristic Improvement of Waste-Polyethylene Asphalt Concrete (2002)

This study is a fundamental research for recycling waste polyethylene film(WPF) in asphalt concrete for roadway pavement. The objective of this study is to develop technology of making waste polyethylene asphalt mixture and evaluate properties of the asphalt concrete containing WPF. Asphalt concrete for surface course of pavement was produced through an appropriate mix-design using dense-graded and gap-graded aggregates. Marshall mix design, indirect tensile strength test, wheel tracking test and tensile fatigue test were performed. Test result showed that some WPF asphalt mixtures had a high tensile property and good resistances against rutting and fatigue cracking, compared with normal asphalt mixture.
A Facile and Efficient Preparation of Pillararenes and a Pillarquinone (2009)

Ring around the roses: The ipso substitution of benzene rings makes a simple and efficient synthesis of pillar[n]arenes (n=5, 6) possible. Pillar[6]arenes (see picture) and pillar[5]quinone, an oxidation product of pillar[5]arene, are novel, highly promising host systems for host–guest chemistry.
Multiway SLCA-based keyword search in XML data (2007)

Keyword search for smallest lowest common ancestors (SLCAs)in XML data has recently been proposed as a meaningful way to identify interesting data nodes inXML data where their subtrees contain an input set of keywords. In this paper, we generalize this useful search paradigm to support keyword search beyond the traditional AND semantics to include both AND and OR boolean operators as well. We first analyze properties of the LCA computation and propose improved algorithms to solve the traditional keyword search problem (with only AND semantics). We then extend our approach to handle general keyword search involving combinations of AND and OR boolean operators. The effectiveness of our new algorithms is demonstrated with a comprehensive experimental performance study.
Road Grade Measurement Using In-Vehicle, Stand-Alone GPS with Barometric Altimeter (2013)

Real-world vehicle fuel use and emission rates are sensitive to road grade. There is a need for a practical method for measuring road grade in combination with on-board measurement of vehicle activity, energy use, and emissions using portable emissions measurement systems (PEMS). This paper focuses on quantification of the accuracy and precision of a low-cost method using a stand-alone global positioning system (GPS) receiver with an in-built barometric altimeter. Approximately 100 one-way runs were made on each of several study routes. The sensitivity of average grade estimates to the averaging distance over which grade is estimated is quantified. The repeatability of vehicle location and distance traveled is quantified. The run-to-run variability and confidence intervals for average estimates of grade are quantified. The accuracy of the grade estimates is evaluated in comparison to LIDAR-based estimates. The low-cost method is shown to be accurate, but imprecision in the measurements leads to a need for typically at least 10 or more repeated runs, depending on the desired precision of the average estimate of grade.
Imperfection loss reduction in viscosity-matched optical fibers (1993)

An optical fiber with a homogeneously viscous cross section is fabricated by utilizing two kinds of dopant which have different effects on host material viscosity. It is confirmed experimentally that matching the viscosity between the core and cladding greatly reduces imperfection loss.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Accelerated Evolution in Inhibitor Domains of Porcine Elafin Family Members (1996)

Through the analysis of the porcine gene encoding the elastase inhibitor elafin, we demonstrated that there are at least three closely related members of the elafin family, and their genes have arisen by accelerated evolution. A porcine genomic DNA library was screened with a previously cloned human elafin cDNA probe, and several positive clones were obtained that can be distinguished by a combination of restriction enzymes. Sequence analysis of these clones revealed the presence of three homologous members whose genes, all consisting of three exons and two introns, are almost identical except the exon 2 sequences encoding the inhibitor domain called "WAP motif"; the intron sequences are related to each other with sequence similarities of 93-98%, whereas the exon 2 sequences exhibited only 60-77% similarities among the three members. The extreme divergence in the exon 2 sequences compared to the highly conserved intron sequences may be generated by accelerated mutations confined in a short stretch of the genes following recent duplication events of a single ancestral gene. An RNase protection assay indicated that the messages of the elafin family members are abundantly expressed in the trachea and intestine, suggesting that the most likely selective forces for the accelerated evolution are extrinsic proteinases produced by invasive microorganisms.
Single-Anchor Localization and Orientation Performance Limits Using Massive Arrays: MIMO <i>vs.</i> Beamforming (2018)

In the next generation of cellular networks, it is desirable to use single access points both for communication and localization. This could be made possible thanks to the combination of femtocells, mm-wave technology and massive antenna arrays, and would overcome the problem of having an over-sized infrastructure for positioning which is, nowadays, the bottleneck for the widespread diffusion of indoor localization systems. In this context, our paper aims at investigating the localization and orientation performance limits employing massive arrays both at the access point and mobile side. To this end, we first asymptotically demonstrate the tightness of the Cramér-Rao bound (CRB) in the massive array regime and that the effect of multipath can be made negligible even for practical values of SNR levels. Successively, we propose a comparison between two different transmitter configurations, namely multiple-input multiple-output (MIMO), where orthogonal waveforms are sent, and beamforming, which takes advantage of highly correlated waveforms and directive array patterns. We also consider random weighting as a trade-off between the diversity gain of MIMO and the high directivity guaranteed by the beamforming. CRB results show the interplay between diversity and beamforming gain as well as the benefits achievable by varying the number of antennas in terms of localization accuracy and multipath mitigation.
Rapid Method of Preparation of Lysoglycosphingolipids and Their Confirmation by Delayed Extraction Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (1996)

We have recently developed a rapid method for the preparation of lysoglycosphingolipids on a small scale, in high yield. This procedure of microwave-mediated saponification of about 1 mg of glycosphingolipid with 0.5 ml of 0.1 M NaOH in methanol for two minutes can be easily repeated if larger amounts of lyso-compounds are needed. We have also found that the new methodology of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry in the reflector mode is extremely effective for the confirmation of different lysoglycosphingolipids together with their long chain base components. The combined method of preparation and confirmation of lysoglycosphingolipids is also important for the identification of long chain bases of various sphingolipids, because the usual analytical method of long-chain bases of sphingolipids depends on acidic methanolysis, which results in the formation of by-products such as O-methylsphingosines and threo-sphingosines.
Role of GB virus C in modulating HIV disease (2012)

GB virus C (GBV-C) is a member of the Flaviviridae family and the most closely related human virus to HCV. However, GBV-C does not replicate in hepatocytes, but rather in lymphocytes. GBV-C has a worldwide distribution and is transmitted sexually, parenterally and through mother-to-child transmission. Thus, co-infection with HCV and HIV is common. Until now, no human disease has been associated with GBV-C infection. However, there are several reports of a beneficial effect of GBV-C on HIV disease progression in vivo. Different mechanisms to explain these observations have been proposed, including modification of antiviral cytokine production, HIV co-receptor expression, direct inhibition of HIV-1 entry, T-cell activation and Fas-mediated apoptosis. Further understanding of these mechanisms may open new strategies for the treatment of HIV/AIDS.
Cortisol Inhibits the Synthesis of Insulin-like Growth Factor-binding Protein-5 in Bone Cell Cultures by Transcriptional Mechanisms (1996)

Glucocorticoids inhibit the synthesis of insulin-like growth factor-binding protein-5 (IGFBP-5) in osteoblasts, but the mechanisms involved are unknown. IGFBP-5 stimulates bone cell growth, and its inhibition by glucocorticoids may be relevant to the action of this binding protein on bone formation. We tested the effects of cortisol on IGFBP-5 expression in cultures of osteoblast-enriched cells from fetal rat calvariae (Ob cells). Cortisol decreased IGFBP-5 polypeptide levels in the extracellular matrix and caused a time- and dose-dependent decrease in IGFBP-5 mRNA. IGFBP-5 transcripts were markedly decreased by cycloheximide, and further suppressive effects of cortisol could not be determined. Cortisol did not modify the decay of IGFBP-5 mRNA in transcriptionally arrested Ob cells. Cortisol decreased IGFBP-5 hnRNA, the rate of IGFBP-5 transcription, and the activity of the murine IGFBP-5 promoter by 35% in transient transfection experiments. Deletion analysis showed that the region responsive to cortisol is from base pairs -70 to +22, and E-box-binding proteins or c-Myb-related nuclear factors may be involved in its regulation. In conclusion, cortisol inhibits IGFBP-5 transcription in Ob cells through the Myb-binding domain. This effect may be partly responsible for the effect of glucocorticoids on bone formation.
Leadership to Match A New Era: Democratizing Society Through Emancipatory Learning (1997)

Leadership models operative during the industrial era were concerned primarily with the development of products. With recent dramatic societal changes, leaders have been forced to shift their focus from products to services. Given this change, many leaders are struggling to identify new directions for effective leadership. Because the goals of democracy cannot be separated from emerging critical needs of the 21 st century, this article will examine the use of a transformative learning theory to facilitate movement toward a social model of leadership. This article also identifies the importance of the role of "followers" as co-participants in a leadership praxis. Leaders are challenged to explore ways to democratize society as a necessary condition for leader effectiveness. Because Americans are currently living through the most rapid change ever experienced in society, new levels of consciousness are needed to explore new definitions of success and progress. The Transformational Learning model is emancipatory for leaders, followers, organizations, and society at large. This critical pedagogical approach is capable of shifting values that are no longer valid. This process is facilitated through the "affective domain" of learning. Issues presented in this article support the need for leaders to respond to societal needs through their personal use of this learning process. The transformative model is entrusted to leaders who are committed to helping to shape the world toward more humanistic goals.
[Study on the clinical application of wuzhi capsule after renal transplantation]. (2011)

WC could significantly increase the blood Tac concentration of renal transplant recipients, reduce their Tac dosages, with no obvious adverse reaction.
ChemInform Abstract: Nucleoside von Fluorzuckern. 15. Mitt. Synthese von 2′,3′‐Didesoxy‐3′‐fluor‐D‐ribofuranosyl‐benzimidazol ‐ ein neues Fluorzucker‐Purinnucleosidanalogon. (1985)

Abstract Im Zusammenhang mit Untersuchungen des Einflusses von synthetischen Purinanalogen mit Fluorzuckem auf Polymerasesysteme werden die beiden Anomeren (III) und (IV) der Titelverbindung aus dem Thymidin (I) und Benzimidazol (II) hergestellt.
Endocannabinoids selectively enhance sweet taste (2009)

Endocannabinoids such as anandamide [N-arachidonoylethanolamine (AEA)] and 2-arachidonoyl glycerol (2-AG) are known orexigenic mediators that act via CB(1) receptors in hypothalamus and limbic forebrain to induce appetite and stimulate food intake. Circulating endocannabinoid levels inversely correlate with plasma levels of leptin, an anorexigenic mediator that reduces food intake by acting on hypothalamic receptors. Recently, taste has been found to be a peripheral target of leptin. Leptin selectively suppresses sweet taste responses in wild-type mice but not in leptin receptor-deficient db/db mice. Here, we show that endocannabinoids oppose the action of leptin to act as enhancers of sweet taste. We found that administration of AEA or 2-AG increases gustatory nerve responses to sweeteners in a concentration-dependent manner without affecting responses to salty, sour, bitter, and umami compounds. The cannabinoids increase behavioral responses to sweet-bitter mixtures and electrophysiological responses of taste receptor cells to sweet compounds. Mice genetically lacking CB(1) receptors show no enhancement by endocannnabinoids of sweet taste responses at cellular, nerve, or behavioral levels. In addition, the effects of endocannabinoids on sweet taste responses of taste cells are diminished by AM251, a CB(1) receptor antagonist, but not by AM630, a CB(2) receptor antagonist. Immunohistochemistry shows that CB(1) receptors are expressed in type II taste cells that also express the T1r3 sweet taste receptor component. Taken together, these observations suggest that the taste organ is a peripheral target of endocannabinoids. Reciprocal regulation of peripheral sweet taste reception by endocannabinoids and leptin may contribute to their opposing actions on food intake and play an important role in regulating energy homeostasis.
The formation of indigotin from indol by soil bacteria (1928)

Abstract Indol (C6 H4 CH : CH . NH) has a wide distribution in nature, being present an several plants and also produced by putrefactive changes in the intestine. There is no evidence as to its fate after decomposition in soil or in sewage. Its non-persistence at the moderately high temperatures of the manure heap may be due to its volatility; its disappearance from sewage and manured soil may have to be assigned to some other cause. Supniewski states that Bacillus pyocyaneus can decompose indol with the production of antkranilic (o-aminobenzoic) acid, although the action is extremely slow. In attempting to isolate from soil by the usual selective method of cultivation bacteria capable of destroying indol, it was found that in mineral salt solution containing indol, the latter rapidly disappeared, some colourless compounds being formed whose nature has not been determined. Two organisms have, however, been isolated that can decompose indol with the formation of blue crystals. The chief cultural characters of these two organisms are described below.