gebhart/patrepeval huggingface dataset:
Apert and Crouzon syndromes—Cognitive development, brain abnormalities, and molecular aspects (2016)

Apert and Crouzon are the most common craniosynostosis syndromes associated with mutations in the fibroblast growth factor receptor 2 (FGFR2) gene. We conducted a study to examine the molecular biology, brain abnormalities, and cognitive development of individuals with these syndromes. A retrospective longitudinal review of 14 patients with Apert and Crouzon syndromes seen at the outpatient Craniofacial Surgery Hospital for Rehabilitation of Craniofacial Anomalies in Brazil from January 1999 through August 2010 was performed. Patients between 11 and 36 years of age (mean 18.29 ± 5.80), received cognitive evaluations, cerebral magnetic resonance imaging, and molecular DNA analyses. Eight patients with Apert syndrome (AS) had full scale intelligence quotients (FSIQs) that ranged from 47 to 108 (mean 76.9 ± 20.2), and structural brain abnormalities were identified in five of eight patients. Six patients presented with a gain-of-function mutation (p.Ser252Trp) in FGFR2 and FSIQs in those patients ranged from 47 to78 (mean 67.2 ± 10.7). One patient with a gain-of-function mutation (p.Pro253Arg) had a FSIQ of 108 and another patient with an atypical splice mutation (940-2A →G) had a FSIQ of 104. Six patients with Crouzon syndrome had with mutations in exons IIIa and IIIc of FGFR2 and their FSIQs ranged from 82 to 102 (mean 93.5 ± 6.7). These reveal that molecular aspects are another factor that can be considered in studies of global and cognitive development of patients with Apert and Crouzon syndrome (CS). © 2016 Wiley Periodicals, Inc.
Hand Hygiene Behavior in a Pediatric Emergency Department and a Pediatric Intensive Care Unit: Comparison of Use of 2 Dispenser Systems (2005)

The type of dispensing system influenced hand hygiene behavior. Nevertheless, overall hand hygiene compliance remained low. In order for interventions to have a major effect on hand hygiene, multiple factors must be considered.
Rule-based expert systems for network management and operations: an introduction (1988)

The functions that can be performed by an integrated communication network management expert system are identified. Expert systems are defined, and knowledge representation, knowledge acquisition, and inference engines are discussed. A sample application problem using OPS5 is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cell Separation by Staphylococcal Protein A‐Coated Erythrocytes (1975)

A method for cell separation according to cell surface markers is described. Heat-aggregated human IgG or IgG antibodies, raised to surface markers of mouse lymphocytes-for example, Ig or theta antigen-are allowed to react with the lymphocytes. When these cells are incubated with sheep erythrocytes coated with protein A of Staphylococcus aureus, rosettes are formed. These rosettes can be separated from nonrosetted lymphocytes by density gradient centrifugation. The erythrocytes of the rosettes are disrupted by complement action or by osmotic shock, and the lymphocytes are recovered. Immunoglobulin-protein A complexes are shed off the cell surfaces by cultivation. In this way cells with, as well as those without, surface markers could be obtained with high purity (up to 80%) and with high viability.
Isolation and characterization of genomic clones corresponding to the human type II procollagengene (1984)

A recombinant human DNA library was screened using probes corresponding to the chick alpha 1 (II) procollagen gene. This resulted in the isolation of 2 different genomic clones, LgHCol(II)a and LgHCol(II)b. LgHCol(II)a was identified as corresponding to the alpha 1(II) gene by comparative hybridization and DNA sequence analysis. DNA sequence established that LgHCol(II)a extends at least from amino acid 694 of the triple helix through 54 amino acids of the COOH-propeptide. Hybridization with a probe containing only the exon at the 3' end of the chicken gene suggests that the clone contains the 3' end of the human gene. Thus LgHCol(II)a contains approximately 40% of the coding sequences of the human type II collagen gene.
Occupancy-Based Control of Indoor Air Ventilation: A Theoretical and Experimental Study (2001)

In this paper, the theoretical and experimental studies of the occupancy-based control of the ventilation are presented to demonstrate the practical usefulness of the occupancy-based scheme for real-time air ventilation control and energy saving. The CO2 concentration is widely used as an indicator of the pollutant contaminant in indoor air and it often changes with time on account of the number of occupants. With the proposed methodology, the number of occupants can be estimated from the real- time measurement of the CO2 concentration of the outdoor air and the indoor air. As known, not only occupants but also buildings themselves contribute to potential indoor-air-quality problems. ASHRAE Standard 62-1989R guideline gives the design ventilation rate based on both occupancy and building space. According to ASHRAE Standard 62-1989R, the estimated number of the occupants and the area of ventilation-controlled space are used to determine the design ventilation rate required for acceptable indoor air quality. This design ventilation rate allows the Heating, Ventilating and Air-conditioning system to produce the acceptable indoor air quality at efficient energy usage. The experimental results show the viability of the proposed method- controlling ventilation based on estimated occupants.
Highly sensitive fiber optic Fabry-Perot geophone with graphene coated PMMA membrane (2017)

A highly sensitive fiber-optic Fabry-Perot interferometric geophone (FFPG) with graphene coated PMMA membrane is proposed and demonstrated, where the graphene coating is used for enhancement of the mechanical strength of the membrane. It is found that the sensitivity of the FFPG is much higher than that of the conventional electrical geophone. Such a novel all-optical geophone with low cost, high sensitivity, electromagnetic interference immunity, easy fabrication and robust structure would have great potential for use in oil/gas exploration and seismic wave detection.
Probabilistic analysis of large finite state machines (1994)

Article Free Access Share on Probabilistic analysis of large finite state machines Authors: Gary D. Hachtel University of Colorado, Dept. of Electrical and Computer Engineering, Boulder, CO University of Colorado, Dept. of Electrical and Computer Engineering, Boulder, COView Profile , Enrico Macii University of Colorado, Dept. of Electrical and Computer Engineering, Boulder, CO and Politecnico di Torino, Dipartimento di Automatica e Informatica, Torino, Italy University of Colorado, Dept. of Electrical and Computer Engineering, Boulder, CO and Politecnico di Torino, Dipartimento di Automatica e Informatica, Torino, ItalyView Profile , Abelardo Pardo University of Colorado, Dept. of Electrical and Computer Engineering, Boulder, CO University of Colorado, Dept. of Electrical and Computer Engineering, Boulder, COView Profile , Fabio Somenzi University of Colorado, Dept. of Electrical and Computer Engineering, Boulder, CO University of Colorado, Dept. of Electrical and Computer Engineering, Boulder, COView Profile Authors Info & Claims DAC '94: Proceedings of the 31st annual Design Automation ConferenceJune 1994 Pages 270–275https://doi.org/10.1145/196244.196374Published:06 June 1994Publication History 52citation355DownloadsMetricsTotal Citations52Total Downloads355Last 12 Months15Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Photodeposition of Molecular Layers on Nanoparticle Substrates (1999)

We report the photodeposition of polymeric layers of nanometer scale thickness onto silica nanoparticle substrates. This was accomplished by ultraviolet irradiation of a solution of functionalized diacetylene monomers in which the silica nanoparticles were suspended. Following photodeposition, the coated nanoparticles were analyzed using transmission electron microscopy and UV−visible spectroscopy. Highly regular polydiacetylene films with thicknesses from 2.5 to 25 nm were produced. The thickness measurements were facilitated by the attachment of small gold nanoparticles onto the surface of the silica nanoparticle substrates prior to photodeposition, to provide contrast in the final TEM image. UV−visible spectroscopy of the deposited films indicates that approximately 40% less conjugation is present relative to that of macroscopic polydiacetylene thin films grown with the same approach. This process yields a unique “nanolaminate” coating which may be useful in the modification of the physical, chemical, or optical properties of nanoparticles.
Novel concepts in understanding and management of glomerular proteinuria (2002)

‘Form follows function’ and ‘time is precious’: these principles are conflated in the glomerular podocyte. They define its function but also the necessity to limit the exposure of podocytes to injurious agents. A number of glomerular disorders that may lead to chronic kidney disease are characterized by simplification and retraction of podocyte foot processes (FP) (effacement). These structural podocyte defects are highly reversible for a certain time and every effort should be undertaken to prevent disease progression and the need for renal replacement therapy, which harbors enormous financial and human costs. Podocytes elaborate a network of processes—major processes and FP, which surround glomerular capillaries. Together with the glomerular basement membrane (GBM) and the glomerular endothelial cells, podocytes provide the structural basis for glomerular filtration w1x. Although it is generally acknowledged that the GBM can restrict the passage of large plasma proteins, there is increasing evidence that the ultimate barrier for proteins larger than albumin is the slit diaphragm (SD). The past 4 years have been extremely fruitful in providing an extensive amount of information on the molecular composition of the SD, and opened up new avenues to understand podocyte function w2,3x. ACE inhibitors and angiotensin receptor blockers have proven effective in ameliorating glomerular proteinuria and slowing of disease progression in proteinuric renal diseases and in diabetic nephropathy in particular w4–8x. In addition, there are novel intriguing experimental data that link the salutary effects of these drugs to changes in the composition of the SD. This comment is focused on the recent progress in understanding the molecular mechanisms that underlie SD dysfunction and the development of proteinuria.
BiNoC: A bidirectional NoC architecture with dynamic self-reconfigurable channel (2009)

A Bidirectional channel Network-on-Chip (BiNoC) architecture is proposed to enhance the performance of on-chip communication. The BiNoC allows each communication channel to be dynamically self-configured to transmit flits in either direction in order to better utilize on-chip hardware resources. This added flexibility promises better bandwidth utilization, lower packet delivery latency, and higher packet consumption rate at each on-chip router. In this paper, a novel on-chip router architecture supporting the self-configuring bidirectional channel mechanism is presented. It is shown that the associated hardware overhead is negligible. Cycle-accurate simulation runs on this BiNoC network under synthetic and real-world traffic patterns demonstrate consistent and significant performance advantage over conventional mesh grid NoC architecture equipped with hard-wired unidirectional channels.
Electronic Structure and Magnetic Properties of Ni<sub>2</sub>MnGa<sub>1-x</sub>Ge<sub>x</sub>and Disordered Ni<sub>2</sub>MnSn Heusler Alloys (2009)

In this work we present the influence of atomic disorder on the electronic and magnetic properties of Ni2MnGa1-xGex and Ni2MnSn Heusler alloys. Ab initio band calculations were performed for the experimental lattice parameters. We applied SPR-KKR-CPA methods in the local spin density approximation.
Enzymic and immunochemical properties of lysozyme. Evaluation of several amino group reversible blocking reagents (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymic and immunochemical properties of lysozyme. Evaluation of several amino group reversible blocking reagentsA. F. S. A. Habeeb and M. Zouhair AtassiCite this: Biochemistry 1970, 9, 25, 4939–4944Publication Date (Print):December 8, 1970Publication History Published online1 May 2002Published inissue 8 December 1970https://pubs.acs.org/doi/10.1021/bi00827a016https://doi.org/10.1021/bi00827a016research-articleACS PublicationsRequest reuse permissionsArticle Views356Altmetric-Citations109LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Moving Up the Information Food Chain: Deploying Softbots on the World Wide Web (1996)

I view the World Wide Web as an information food chain (figure 1). The maze of pages and hyperlinks that comprise the Web are at the very bottom of the chain. The WebCrawlers and Alta Vistas of the world are information herbivores; they graze on Web pages and regurgitate them as searchable indices. Today, most Web users feed near the bottom of the information food chain, but the time is ripe to move up. Since 1991, we have been building information carnivores, which intelligently hunt and feast on herbivores in Unix (Etzioni, Lesh, &amp; Segal 1993), on the Internet (Etzioni &amp; Weld 1994), and on the Web (Doorenbos, Etzioni, &amp; Weld 1996; Selberg &amp; Etzioni 1995; Shakes, Langheinrich, &amp; Etzioni 1996). Motivation Today&apos;s Web is populated by a panoply of primitive but popular information services. Consider, for example, an information cow such as Alta Vista. Alta Vista requires massive memory resources (to store an index of the Web) and tremendous network bandwidth (to create and continually ...
Multiple resonant inverters in parallel with a novel current sharing control based on current decomposition method (2006)

The control issue of multiple inverter modules operated in parallel is investigated for high frequency AC power distribution architectures, where multiple high frequency resonant inverters are connected in parallel to the high frequency, high voltage low current (HVLC) AC bus, to feed a number of point-of-use power supplies. The circulating current in the multiple inverter system is analyzed first. A novel control scheme is proposed based on the active and reactive current decomposition concept. In the proposed control, there are two loops, the current sharing control loop and the voltage feedback control loop. For the current sharing loop, the active current and reactive current are controlled separately. It is shown that the minimization of the circulating current can be achieved if both the active current and reactive current of the equivalent load are evenly distributed among activated inverter modules. This control method is superior to the scalar control where only the magnitudes of the currents are controlled. Performance is verified with both simulations and experiments on a prototype HFAC power distribution system where two two-stage resonant inverter modules of 500 kHz, 100W are connected in parallel through small connection inductors to the HFAC bus of 500 kHz, 28V (RMS).
Immune responses in mice to DNA vaccination using the C-terminus of p43 (p12) from Mycobacterium avium subspcies paratuberculosis (2000)

Immune responses in mice to DNA vaccination using the C-terminus of p43 (p12) from Mycobacterium avium subspcies paratuberculosis
Behavior-driven clustering of queries into topics (2011)

Categorization of web-search queries in semantically coherent topics is a crucial task to understand the interest trends of search engine users and, therefore, to provide more intelligent personalization services. Query clustering usually relies on lexical and clickthrough data, while the information originating from the user actions in submitting their queries is currently neglected. In particular, the intent that drives users to submit their requests is an important element for meaningful aggregation of queries. We propose a new intent-centric notion of topical query clusters and we define a query clustering technique that differs from existing algorithms in both methodology and nature of the resulting clusters. Our method extracts topics from the query log by merging missions, i.e., activity fragments that express a coherent user intent, on the basis of their topical affinity. Our approach works in a bottom-up way, without any a-priori knowledge of topical categorization, and produces good quality topics compared to state-of-the-art clustering techniques. It can also summarize topically-coherent missions that occur far away from each other, thus enabling a more compact user profiling on a topical basis. Furthermore, such a topical user profiling discriminates the stream of activity of a particular user from the activity of others, with a potential to predict future user search activity.
[Synthetic inhibitors of serine proteinases. 13. Quantitative structure-activity relationship for inhibition of trypsin and thrombin by 4-amidinophenyl compounds with a ketone structure]. (1976)

To establish quantitative structure-activity relationships for the inhibition of trypsin, plasmin and thrombin by 4-amidinophenyl compounds with a keto group, attempts have been made to detect correlations between data on inhibition and substituent constants. The inhibitor activity of the derivatives is described by lipophilic or steric substituent constants using linear free energy relationships. To describe the action of beta-ketones, an additional sigma I term is necessary. The lipophilic or steric term stands for binding of the inhibitor side chain to a second hydrophobic binding site of the enzyme. The electronic term describing inductive influences on the keto group suggests the contribution of the beta-keto group to the enzyme inhibitor binding via a tetrahedral conformation of the carbonyl carbon.
Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity (2017)

KDM subfamily 6 enzymes KDM6A and KDM6B specifically catalyze demethylation of di- and trimethylated lysine on histone 3 lysine 27 (H3K27me3/2) and play an important role in repression of developmental genes. Despite identical amino acid sequence in the immediate surroundings of H3K9me3/2 (ARKS), the enzymes do not catalyze demethylation of this general marker of repression. To address this question for KDM6B, we used computational methods to identify H3(17-33)-derived peptides with improved binding affinity that would allow co-crystallization with the catalytic core of human KDM6B (ccKDM6B). A total of five peptides were identified, and their IC<sub>50</sub> values were determined in a matrix-assisted laser desorption ionization time-of-flight-based assay. Despite none of the peptides showing affinity significantly higher than that of the H3(17-33) peptide, it was possible to co-crystallize ccKDM6B with a H3(17-33)A21M peptide. This structure reveals the interactions between the KDM6B zinc binding domain and the H3(17-23) region. Although KDM6A and KDM6B differ in primary sequence, particularly in the H3L20 binding pocket of the zinc binding domains, where two histidines in KDM6A have been replaced by a glutamate and a tyrosine, they bind H3(17-23) in a very similar fashion. This structure shows that KDM6B, in analogy with KDM6A, also uses the zinc binding domain to achieve H3K27me3/me2 specificity. The histidine to glutamine substitution at amino acid position 1564 in the KDM6B zinc binding domain can further explain why KDM6B binds substrates with an affinity higher than that of KDM6A.
AIDS â Transformando casos em Histârias: uma pesquisa-intervenâçâo (2007)

O objetivo desta pesquisa-intervenA§A£o foi integrar a produA§A£o de conhecimento com a intervenA§A£o social e polA­tica, construindo estratA©gias metodolA³gicas para reunir, analisar e discutir as narrativas disseminadas sobre o tema da AIDS a partir de uma perspectiva histA³rica. Os resultados destacam a importA¢ncia de se levar em consideraA§A£o a dinA¢mica da doenA§a no campo social e seus modos de representaA§A£o na cultura ao longo da histA³ria, como aspectos fundamentais para a implementaA§A£o de polA­ticas sociais de prevenA§A£o que sejam efetivamente promissoras.
Whole Blood Processing for Measurement of Signaling Proteins by Flow Cytometry (2008)

Signal transduction pathways link external stimuli with cellular responses, which normally regulate cell proliferation, death, and differentiation. The study of signal transduction was revolutionized through the development of phospho-specific antibodies that recognize proteins only when they are phosphorylated at specific sites. As discussed by Nolan and co-workers (UNIT ), one of the unique features of flow cytometry is its ability to perform correlated measurements of multiple phosphorylation states at the single cell level. This provides insight into the complexity of signaling networks that is not obtained by standard biochemical techniques. Furthermore, in combination with other phenotypic markers, flow cytometry can measure alterations in signaling pathways in subpopulations of cells. This clearly has wide potential for studying disorders of the hematopoietic and immune systems.
Similarity Search in Trajectory Databases (2007)

Trajectory database (TD) management is a relatively new topic of database research, which has emerged due to the explosion of mobile devices and positioning technologies. Trajectory similarity search forms an important class of queries in TD with applications in trajectory data analysis and spatiotemporal knowledge discovery. In contrast to related works which make use of generic similarity metrics that virtually ignore the temporal dimension, in this paper we introduce a framework consisting of a set of distance operators based on primitive (space and time) as well as derived parameters of trajectories (speed and direction). The novelty of the approach is not only to provide qualitatively different means to query for similar trajectories, but also to support trajectory clustering and classification mining tasks, which definitely imply a way to quantify the distance between two trajectories. For each of the proposed distance operators we devise highly parametric algorithms, the efficiency of which is evaluated through an extensive experimental study using synthetic and real trajectory datasets.