gebhart/patrepeval huggingface dataset:
Synthesis and characterization of the first fullerene-peptide (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of the first fullerene-peptideMaurizio Prato, Alberto Bianco, Michele Maggini, Gianfranco Scorrano, Claudio Toniolo, and Fred WudlCite this: J. Org. Chem. 1993, 58, 21, 5578–5580Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/jo00073a004https://doi.org/10.1021/jo00073a004research-articleACS PublicationsRequest reuse permissionsArticle Views508Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
DC-link Capacitor Voltage Balancing for a Five-Level Diode-Clamped Active Power Filter using Redundant Vectors (2013)

This paper investigates the compensation and modulation processes of the five-level diode-clamped APF, compensating a three-phase rectified RL load by redundant vectors. From the analysis, a hybrid SVM algorithm allows capacitor voltage balancing. Simulation and experimental results validate the SVM algorithm.
Estrogen-Dependent Cyclin E-cdk2 Activation through p21 Redistribution (1997)

In order to elucidate the mechanisms by which estrogens and antiestrogens modulate the growth of breast cancer cells, we have characterized the changes induced by estradiol that occur during the G1 phase of the cell cycle of MCF-7 human mammary carcinoma cells. Addition of estradiol relieves the cell cycle block created by tamoxifen treatment, leading to marked activation of cyclin E-cdk2 complexes and phosphorylation of the retinoblastoma protein within 6 h. Cyclin D1 levels increase significantly while the levels of cyclin E, cdk2, and the p21 and p27 cdk inhibitors are relatively constant. However, the p21 cdk inhibitor shifts from its association with cyclin E-cdk2 to cyclin D1-cdk4, providing an explanation for the observed activation of the cyclin E-cdk2 complexes. These results support the notion that cyclin D1 has an important role in steroid-dependent cell proliferation and that estrogen, by regulating the activities of G1 cyclin-dependent kinases, can control the proliferation of breast cancer cells.
Log smooth extension of a family of curves and semi-stable reduction (2004)

We show that a family of smooth stable curves defined on the interior of a log regular scheme is extended to a log smooth scheme over the whole log regular scheme, if it is so at each generic point of the boundary, under a very mild assumption. We also include a proof of the fact that a log smooth scheme over a discrete valuation ring has potentially a semi-stable model. As a consequence, we show that a hyperbolic polycurve in the sense of Mochizuk over a discrete valuation field has potentially a proper semi-stable model if the characteristic of the residue field is sufficiently large.
Stereospecificity of Reactions Catalyzed by Bacterial D-Amino Acid Transaminase (1989)

The spectral shift from 420 to 338 nm when pure bacterial D-amino acid transaminase binds D-amino acid substrates is also exhibited in part by high concentrations of L-amino acids (L-alanine and L-glutamate) but not by simple dicarboxylic acids or monoamines. Slow processing of L-alanine to D-alanine was observed both by coupled enzymatic assays using D-amino acid oxidase and by high pressure liquid chromatography analysis employing an optically active chromophore (Marfey's reagent). When the acceptor for L-alanine was alpha-ketoglutarate, D-glutamate was also formed. This minor activity of the transaminase involved both homologous (L-alanine and D-alanine) and heterologous (L-alanine and D-glutamate) substrate pairs and was a function of the nature of the keto acid acceptor. In the presence of alpha-ketoisovalerate, DL-alanine was almost completely processed to D-valine; within the limits of the assay no L-valine was detected. With alpha-ketoisocaproate, 90% of the DL-alanine was converted to D-leucine. In the mechanism of this transaminase reaction, there may be more stereoselective constraints for the protonation of the quinonoid intermediate during the second half-reaction of the transamination reaction, i.e. the donation of the amino group from the pyridoxamine 5'-phosphate coenzyme to a second keto acid acceptor, than during removal of the alpha proton in the initial steps of the reaction pathway. Thus, with this D-amino acid transaminase, the discrete steps of transamination ensure fidelity of the stereospecificity of reaction pathway.
Quantitative Troposphere Composition Retrievals from Satellite Measurements: Initial Results (2006)

The direct measurement of tropospheric trace gases from space is difficult and so it is necessary to combine models and data to fully exploit the potential of observations. To obtain quantitative estimates of the tropospheric abundance the contamination from clouds and the stratosphere have to be removed accurately, and the multiple-scattering of photons in the troposphere has to be correctly interpreted. The aim of this project is to introduce a new method for calculating tropospheric column amounts of trace gases that reduces the large error that is already associated with this kind of calculation. We will initially focus on estimating the concentration of NO2, BrO, SO2 and HCHO using data from the Global Ozone Monitoring Experiment (GOME). There are two steps to this process.
The Flagellar Sigma Factor FliA (ς<sup>28</sup>) Regulates the Expression of<i>Salmonella</i>Genes Associated with the Centisome 63 Type III Secretion System (2000)

One of the essential features of all pathogenic strains of Salmonella enterica is the ability to enter into nonphagocytic cells. This pathogenic property is mediated by the Salmonella pathogenicity island 1 (SPI-1)-encoded type III secretion system. Expression of components and substrates of this system is subject to complex regulatory mechanisms. These mechanisms include a number of specific and global transcriptional regulatory proteins. In this study we have compared in S. enterica serovars Typhimurium and Typhi the effect of mutations in flagellar genes on the phenotypes associated with the SPI-1 type III protein secretion system. We found that serovar Typhi strains carrying a null mutation in either of the flagellar regulatory genes flhDC or fliA were severely deficient in entry into cultured epithelial cells and macrophage cytotoxicity. This defect could not be reversed by applying a mild centrifugal force, suggesting that the effects of the mutations were not due to the absence of motility. In contrast, the same mutations had no significant effect on the ability of serovar Typhimurium to enter into cultured Henle-407 cells or to induce macrophage cell death. Consistent with these observations, we found that the mutations in the flagellar regulatory proteins significantly reduced the expression of components of the SPI-1-encoded type III system in serovar Typhi but had a marginal effect in serovar Typhimurium. Our results therefore indicate that there is an overlap between regulatory mechanisms that control flagellar and type III secretion gene expression in Salmonella serovar Typhi.
A fundamental study of inter-area oscillations in power systems (1991)

A fundamental study of the nature of inter-area oscillations in power systems is presented. The effects of the system structure, generator modeling, excitation type, and system loads are discussed in detail. Both small signal and transient stability analyses are used to determine the characteristics of the system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Tube theory of entangled polymer dynamics (2002)

The dynamics of entangled flexible polymers is dominated by physics general to many chemical systems. It is an appealing interdisciplinary field where experimental and theoretical physics can work closely with chemistry and chemical engineering. The role of topological interactions is particularly important, and has given rise to a successful theoretical framework: the 'tube model'. Progress over the last 30 years is reviewed in the light of specially-synthesized model materials, an increasing palette of experimental techniques, simulation and both linear and nonlinear rheological response. Our current understanding of a series of processes in entangled dynamics: 'reptation', 'contour length fluctuation' and 'constraint-release' are set in the context of remaining serious challenges. Especial attention is paid to the phenomena associated with polymers of complex topology or 'long chain branching'.
Reduction of Certain Insects Infesting Alfalfa by Use of Sabadilla1 (1945)

Journal Article Reduction of Certain Insects Infesting Alfalfa by Use of Sabadilla Get access T. C. Allen, T. C. Allen University of Wisconsin, Madison2 Search for other works by this author on: Oxford Academic PubMed Google Scholar F. J. Dexiieimer, F. J. Dexiieimer University of Wisconsin, Madison2 Search for other works by this author on: Oxford Academic PubMed Google Scholar Elsie Cole Elsie Cole University of Wisconsin, Madison2 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 38, Issue 3, 1 June 1945, Pages 389–390, https://doi.org/10.1093/jee/38.3.389a Published: 01 June 1945
How Progressive is the U.S. Federal Tax System? A Historical and International Perspective (2007)

This paper provides estimates of federal tax rates by income groups in the United States since 1960, with special emphasis on very top income groups. We include individual and corporate income taxes, payroll taxes, and estate and gift taxes. The progressivity of the U.S. federal tax system at the top of the income distribution has declined dramatically since the 1960s. This dramatic drop in progressivity is due primarily to a drop in corporate taxes and in estate and gift taxes combined with a sharp change in the composition of top incomes away from capital income and toward labor income. The sharp drop in statutory top marginal individual income tax rates has contributed only moderately to the decline in tax progressivity. International comparisons confirm that is it critical to take into account other taxes than the individual income tax to properly assess the extent of overall tax progressivity, both for time trends and for cross-country comparisons. The pattern for the United Kingdom is similar to the U.S. pattern. France had less progressive taxes than the United States or the United Kingdom in 1970 but has experienced an increase in tax progressivity and has now a more progressive tax system than the United States or the United Kingdom.
Clinical and molecular aspects of the Simpson-Golabi-Behmel syndrome (1998)

The Simpson-Golabi-Behmel syndrome (SGBS) is an overgrowth/multiple congenital anomalies/dysplasia syndrome caused by a mutant X-linked gene. The spectrum of its clinical manifestations is broad, varying from very mild forms in carrier females to infantile lethal forms in affected males. A typically affected male will show tall stature, "coarse" face, supernumerary nipples, congenital heart defect, and generalized muscular hypotonia. Mental development is normal in most cases. There is an increased risk of neoplasia in infancy, especially Wilms tumor. The SGBS gene spans 500 kilobases in the Xq26 region and contains eight exons. It encodes an extracellular proteoglycan, designated glypican 3 (GPC3), capable of interacting with the insulin-like growth factor IGF2. At present, only deletions of various sizes have been found in a number of affected families.
ONDE A LUTA ENSINA: OLHOS DE APRENDIZ NO MOVIMENTO SOCIAL (2002)

A participacao de pesquisadores em um movimento social permite compreender e (res)significar muitos saberes que so ganham sentido se vivenciados no interior de grupos e na realidade dos sujeitos que vivem as carencias que afetam, cotidianamente, seus modos de viver. O artigo aborda o tema, derivado de uma intensa experiencia pessoal, buscando revelar sentidos que um movimento social assume ao lidar com as sempre novas carencias das populacoes pobres, cujos direitos negados sao ainda visiveis na decada de 1990. Nessa busca, emergem conhecimentos e poderes, desafiando a compreensao de algumas categorias – luta e festa, por exemplo –, para alem do movimento social. Essas categorias se impoem como indispensaveis para o alargamento do campo da educacao de jovens e adultos e das possibilidades de transformar, pela acao historica dos sujeitos, a vida cotidiana.
Ultrasound-assisted electrochemical reduction of emulsions in aqueous media (1997)

The electrochemical reduction of diethylmaleate, diethylfumarate and diethylacetylene dicarboxylate in the form of microscopic droplets generated by applying power ultrasound to aqueous electrolyte media allows a clean hydrogenation of the carbon–carbon double/triple bond whilst providing a novel and versatile methodology for electrochemistry of insoluble materials in aqueous environments.
Disruption of<i>PPT1</i>or<i>PPT2</i>causes neuronal ceroid lipofuscinosis in knockout mice (2001)

PPT1 and PPT2 encode two lysosomal thioesterases that catalyze the hydrolysis of long chain fatty acyl CoAs. In addition to this function, PPT1 (palmitoyl-protein thioesterase 1) hydrolyzes fatty acids from modified cysteine residues in proteins that are undergoing degradation in the lysosome. PPT1 deficiency in humans causes a neurodegenerative disorder, infantile neuronal ceroid lipofuscinosis (also known as infantile Batten disease). In the current work, we engineered disruptions in the PPT1 and PPT2 genes to create "knockout" mice that were deficient in either enzyme. Both lines of mice were viable and fertile. However, both lines developed spasticity (a "clasping" phenotype) at a median age of 21 wk and 29 wk, respectively. Motor abnormalities progressed in the PPT1 knockout mice, leading to death by 10 mo of age. In contrast, the majority of PPT2 mice were alive at 12 mo. Myoclonic jerking and seizures were prominent in the PPT1 mice. Autofluorescent storage material was striking throughout the brains of both strains of mice. Neuronal loss and apoptosis were particularly prominent in PPT1-deficient brains. These studies provide a mouse model for infantile neuronal ceroid lipofuscinosis and further suggest that PPT2 serves a role in the brain that is not carried out by PPT1.
Novel aplanatic designs (2009)

We have discovered an aplanatic design that contributes to a celebrated problem in classical optics in a novel way. In so doing new devices are envisioned with applications to illumination, concentration, and imaging.
Identification of Id2 as a Globin Regulatory Protein by Representational Difference Analysis of K562 Cells Induced To Express γ-Globin with a Fungal Compound (1999)

A fungus-derived compound (OSI-2040) which induces fetal globin expression in the absence of erythroid cell differentiation was identified in a high-throughput drug discovery program. We utilized this compound to isolate gamma-globin regulatory genes that are differentially expressed in OSI-2040-induced and uninduced cells in the human erythroleukemia cell line K562. Representational difference analysis (RDA) of cDNA revealed several genes that were significantly up- or down-regulated in OSI-2040-induced cells. One gene whose expression was markedly enhanced was the gene for the helix-loop-helix (HLH) transcription factor Id2. Southern analysis of RDA amplicons demonstrated progressive enrichment of Id2 with each successive subtraction of uninduced cDNA from induced cDNA. Northern analysis of OSI-2040-induced K562 cells confirmed that Id2 expression was directly up-regulated coordinately with gamma-globin. Analysis of other inducers of fetal globin demonstrated up-regulation of Id2 with sodium butyrate but not with hemin. Retrovirus-mediated overexpression of Id2 in K562 cells reproduced the enhancement of endogenous globin expression observed with OSI-2040 induction. Functional assays demonstrated that an E-box element in hypersensitivity site 2 is required for Id2-dependent enhancement of gamma-promoter activity. Protein binding studies suggest that alterations in E-box site occupancy by basic HLH proteins may influence this activity, thus expanding the potential role of these factors in globin gene regulation.
Investigation of DC-DC resonant converter constructed nanostructure magnetic core transformer for power distribution system (2012)

A high frequency power converter system suitable to replace a typical power distribution transformer is discussed. The new power converter systems contain a number of high power DC-DC converters as main components. Magnetic circuits are widely used in the switching converters. Increasing the switching frequency in switching converters is considered an advantage. Because with increasing frequency, can reduce size of the magnetic components. But with increasing frequency, conventional magnetic core and winding losses increase. In fact this is most important limitation in increasing the switching frequency in switching converters. Other limitations of increased frequency, is increasing magnetic parasites. Increased frequency of transformer is the causing of increased leakage inductance and equivalent capacitance between the windings. These parasites cause unwanted voltages and leakage currents in the transformer, which increases losses and reduce the efficiency will be that result. This paper presents the DC-DC converter with resonant commutation. The described converter employs a low profile high frequency transformer, a LCL resonant tank and two full bridge converters. In this paper, after evaluation the features of the nanostructure magnetic core, Design issues of high power density transformers for DC/DC converter systems are discussed. Under the specified operating condition, the transformer is designed to achieve the minimum volume. Finemet nanocrystalline magnetic material is suitable for the high frequency applications, due to its superior low loss density and high operating temperature characteristics. Based on an product area approach, transformer design and equivalent circuit is developed, with leakage inductances calculated. The analysis has been verified by the simulations results.
Train-Track Interaction and Mechanisms of Irregular Wear on Wheel and Rail Surfaces (2003)

Summary High-frequency train-track interaction and mechanisms of wheel/rail wear that is non-uniform in magnitude around/along the running surface are surveyed. Causes, consequences and suggested remedies to relieve the problems are discussed for three types of irregular wheel/rail wear: (1) short-pitch rail corrugation on tangent tracks and large radius curves, (2) wheel corrugation as caused by tread braking, and (3) wheel polygonalisation. The state-of-the-art in modelling of dynamic train-track interaction in conjunction with prediction of irregular wear is reviewed.
A method for cDNA cloning in COS cells irrespective of subcellular site of expression (1991)

Journal Article A method for cDNA cloning in COS cells irrespective of subcellular site of expression Get access E. Horst, E. Horst Search for other works by this author on: Oxford Academic PubMed Google Scholar P.L.J. Wijngaard, P.L.J. Wijngaard 1Department of Immunology, Academic Hospital UtrechtUtrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Metzelaar, M. Metzelaar 1Department of Immunology, Academic Hospital UtrechtUtrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar E.J.E.G. Bast, E.J.E.G. Bast 1Department of Immunology, Academic Hospital UtrechtUtrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar H.C. Clevers H.C. Clevers * 1Department of Immunology, Academic Hospital UtrechtUtrecht, The Netherlands * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 16, 25 August 1991, Page 4556, https://doi.org/10.1093/nar/19.16.4556 Published: 25 August 1991 Article history Accepted: 02 July 1991 Published: 25 August 1991
Theory of Clock Synchronization and Mutual Exclusion in Networked Control Systems (1999)

Process Synchronization, Mutual Exclusion and Deadlock Freedom are basic issues in Distributed Systems.
A fast FORTRAN implementation of the U. S. naval research laboratory algorithm for automatic translation of english text to VOTRAX parameters (2005)

The U. S. Naval Research Laboratories algorithm of Elovitz et. al. enables automatic transalation of English text to IPA and, via a further mapping, to input for a "phoneme" based synthesizer such as VOTRAX. A novel feature of the NRL algorithm is that the set of 300+ rules used to perform the translation is read in at run time and thus may be easily altered to expand the set of rules in general or to treat special cases such as jargon. While the orignal NRL FASBOL version ran about 4 to 5 times real time on a PDP-10, Broihier and Crowley implelemented a BASIC Plus version which translated up to 165 words per minute on a PDP-11/70. The program included here consists essentially of a FORTRAN control structure with calls to string manipulation subroutines, available as efficient library routines under the PDP-11 RT-11 operating system. The software runs in less than real time on an LSI-11 with 16K of memory. Alternatively, using the string manipulation routine definitions provided, an all-FORTRAN version may be written. Finally, the straightforward, non-recursive structure employed can implemented in other high level languages. In fact, a PL/M version has been written which, using calls to assembler routines employing block move instructions, will run real time on a Zilog Z-80.
Prospective Study of Clinical Phenotypes in Neuropsychiatric Systemic Lupus Erythematosus; Multidisciplinary Approach to Diagnosis and Therapy (2012)

We describe multidisciplinary consensus as a standard for diagnosing and defining phenotypes in NPSLE. These phenotypes show specific characteristics, which can be used to support diagnosis and guide therapeutic decisions. Clinical phenotyping and selection of patients becomes increasingly important when advances in experimental science lead to new targets for therapy in NPSLE.
Activity of posaconazole in the treatment of central nervous system fungal infections (2005)

These data suggest that posaconazole, as an oral medication, has clinical activity against fungal infections of the CNS and may provide a valuable alternative to parenteral therapy in patients failing existing antifungal agents.