gebhart/patrepeval huggingface dataset:
Locality Aware DAG-Scheduling for LU-Decomposition (2015)

Modern computers have deepening memory hierarchies with multiple levels of (partially shared) caches and non-uniform memory access (NUMA). This makes it increasingly difficult and important to schedule computations in such a way that expensive memory accesses are avoided.In this paper we are choosing LU-decomposition for a case study since its use in the famous LINPACK benchmark means that highly tuned codes are already available. Our approach is to perform the very same computations as a leading implementation (PLASMA) but to schedule them in a more locality aware way. In particular, we better take into account when independent subtasks share the same input data and we explicitly address NUMA-effects coordinating memory layout and task scheduling. These measures lead to up to 36 % performance improvement compared to PLASMA.
Interference in a two-site immunoradiometric assay for thyrotropin in a child. (1985)

Journal Article Interference in a two-site immunoradiometric assay for thyrotropin in a child. Get access C F Cusick, C F Cusick Search for other works by this author on: Oxford Academic Google Scholar K Mistry, K Mistry Search for other works by this author on: Oxford Academic Google Scholar G M Addison G M Addison Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 31, Issue 2, 1 February 1985, Pages 348–349, https://doi.org/10.1093/clinchem/31.2.348 Published: 01 February 1985
Instrumented measurement of anterior laxity of the knee. (1985)

We performed instrumented measurement of anterior-posterior laxity of the knee in thirty-three cadaver specimens, 338 normal subjects, and eighty-nine patients with unilateral disruption of the anterior cruciate ligament. The test instrument was the Medmetric knee arthrometer, model KT-2000. We measured total anterior-posterior laxity, produced by anterior and posterior loads of eighty-nine newtons (twenty pounds), and the anterior compliance index. The total anterior-posterior laxity is composed of an anterior displacement and a posterior displacement; these are measured from a testing reference position, defined as the resting position of the knee after applying and then releasing a posterior load of eighty-nine newtons. The anterior compliance index is defined as the anterior displacement between an anterior load of sixty-seven newtons and one of eighty-nine newtons. All tests were performed with the knee held on a thigh support that placed the knee in 20 +/- 5 degrees of flexion. The mean anterior displacement at eighty-nine newtons was 5.7 millimeters in a group of normal subjects and 13.0 millimeters in a group of patients with a disrupted anterior cruciate ligament. Ninety-two per cent of the normal subjects had a left knee-right knee difference in anterior displacement of no more than two millimeters, while 96 per cent of the patients with a unilateral disruption of the anterior cruciate ligament had an injured knee-normal knee difference in anterior displacement of more than two millimeters. Ninety-three per cent of the normal subjects had a difference in the left-right compliance index of no more than 0.5 millimeter, and 85 per cent of the patients with unilateral disruption of the anterior cruciate ligament had a difference in the compliance index of the injured and normal sides of more than 0.5 millimeter.
Scaling link-based similarity search (2005)

To exploit the similarity information hidden in the hyperlink structure of the web, this paper introduces algorithms scalable to graphs with billions of vertices on a distributed architecture. The similarity of multi-step neighborhoods of vertices are numerically evaluated by similarity functions including SimRank [20], a recursive refinement of cocitation; PSimRank, a novel variant with better theoretical characteristics; and the Jaccard coefficient, extended to multi-step neighborhoods. Our methods are presented in a general framework of Monte Carlo similarity search algorithms that precompute an index database of random fingerprints, and at query time, similarities are estimated from the fingerprints. The performance and quality of the methods were tested on the Stanford Webbase [19] graph of 80M pages by comparing our scores to similarities extracted from the ODP directory [26]. Our experimental results suggest that the hyperlink structure of vertices within four to five steps provide more adequate information for similarity search than single-step neighborhoods.
Triple interpenetration in [Ag(4,4′-bipyridine)][NO<sub>3</sub>], a cationic polymer with a three-dimensional motif generated by self-assembly of ‘T-shaped’ building blocks (1995)

We report the synthesis and single-crystal X-ray structure of a triply interpenetrated cationic framework with a three-dimensional motif that is based upon T-shaped building blocks generated by silver(I) cations and 1 equivalent of 4,4′-bipyridine.
Interaction and Comparison of a Class I Hydrophobin from <i>Schizophyllum commune</i> and Class II Hydrophobins from <i>Trichoderma reesei</i> (2006)

Hydrophobins fulfill a wide spectrum of functions in fungal growth and development. These proteins self-assemble at hydrophilic-hydrophobic interfaces into amphipathic membranes. Hydrophobins are divided into two classes based on their hydropathy patterns and solubility. We show here that the properties of the class II hydrophobins HFBI and HFBII of Trichoderma reesei differ from those of the class I hydrophobin SC3 of Schizophyllum commune. In contrast to SC3, self-assembly of HFBI and HFBII at the water-air interface was neither accompanied by a change in secondary structure nor by a change in ultrastructure. Moreover, maximal lowering of the water surface tension was obtained instantly or took several minutes in the case of HFBII and HFBI, respectively. In contrast, it took several hours in the case of SC3. Oil emulsions prepared with HFBI and SC3 were more stable than those of HFBII, and HFBI and SC3 also interacted more strongly with the hydrophobic Teflon surface making it wettable. Yet, the HFBI coating did not resist treatment with hot detergent, while that of SC3 remained unaffected. Interaction of all the hydrophobins with Teflon was accompanied with a change in the circular dichroism spectra, indicating the formation of an alpha-helical structure. HFBI and HFBII did not affect self-assembly of the class I hydrophobin SC3 of S. commune and vice versa. However, precipitation of SC3 was reduced by the class II hydrophobins, indicating interaction between the assemblies of both classes of hydrophobins.
Hydramnios: anomaly prevalence and sonographic detection (2002)

The anomaly detection rate in pregnancies with hydramnios was nearly 80%, irrespective of the degree of amniotic fluid increase. Residual anomaly risk after normal sonographic evaluation was 2% or less if hydramnios was mild or moderate and 11% if severe.
A step-by-step debugging technique to facilitate mashup development and maintenance (2010)

With Web mashups, data from different Web documents and services are mashed together to create a new functionality. The mashup developer usually has a clear vision of the desired output, i.e., the resulting Web page to present to the end user. Complex mashups require multiple processing steps, and become hard to debug if the delivered result is not as expected. In this paper we propose an approach that supports step-by-step debugging for declarative development of data mashups. A dependency graph is constructed from the mashup definition, and developers are able to define breakpoints to inspect a snapshot of the running mashup execution. A Web 2.0 application visualizes the intermediate results in each processing step. On top of that, it is possible to specify expected and unexpected result elements. If the result does not comply with the specifications, the platform helps to identify the processing step which caused the error.
Termination of Persistent Atrial Fibrillation Resistant to Cardioversion by a Single Radiofrequency Application (2003)

This report describes the termination of persistent AF refractory to multiple cardioversions and antiarrhythmic therapy in a patient without structural heart disease, with a single radiofrequency application delivered in the left upper pulmonary vein. The observations and failure of repeated internal and external cardioversion suggest a rapidly firing arrhythmia focus sustaining atrial fibrillation amenable to curative pulmonary vein ablation.
Growth Enhancement of Transgenic Mice Expressing Human Insulin-Like Growth Factor I* (1988)

A line of transgenic mice carrying a chimeric gene composed of human insulin-like growth factor I (IGF-I) coding sequences fused to the mouse metallothionein I promoter was generated to study the effects of chronically elevated exposure to IGF-I. Mice in this line overexpress IGF-I in most tissues studied and have circulating IGF-I levels 1.5 times the normal value. This results in a growth response manifested by a 1.3-fold increase in weight as a result of selective organomegaly without an apparent increase in skeletal growth. In addition, expression of the endogenous GH and IGF-I genes is inhibited. These results are consistent with IGF-I playing an important role in the control of somatic growth.
Non-Intrusive Load Monitoring Approaches for Disaggregated Energy Sensing: A Survey (2012)

Appliance Load Monitoring (ALM) is essential for energy management solutions, allowing them to obtain appliance-specific energy consumption statistics that can further be used to devise load scheduling strategies for optimal energy utilization. Fine-grained energy monitoring can be achieved by deploying smart power outlets on every device of interest; however it incurs extra hardware cost and installation complexity. Non-Intrusive Load Monitoring (NILM) is an attractive method for energy disaggregation, as it can discern devices from the aggregated data acquired from a single point of measurement. This paper provides a comprehensive overview of NILM system and its associated methods and techniques used for disaggregated energy sensing. We review the state-of-the art load signatures and disaggregation algorithms used for appliance recognition and highlight challenges and future research directions.
Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant (2020)

Medicinal use of <i>Cannabis sativa</i> L. has an extensive history and it was essential in the discovery of phytocannabinoids, including the <i>Cannabis</i> major psychoactive compound-Δ9-tetrahydrocannabinol (Δ9-THC)-as well as the G-protein-coupled cannabinoid receptors (CBR), named cannabinoid receptor type-1 (CB1R) and cannabinoid receptor type-2 (CB2R), both part of the now known endocannabinoid system (ECS). Cannabinoids is a vast term that defines several compounds that have been characterized in three categories: (i) endogenous, (ii) synthetic, and (iii) phytocannabinoids, and are able to modulate the CBR and ECS. Particularly, phytocannabinoids are natural terpenoids or phenolic compounds derived from <i>Cannabis sativa</i>. However, these terpenoids and phenolic compounds can also be derived from other plants (non-cannabinoids) and still induce cannabinoid-like properties. Cannabimimetic ligands, beyond the <i>Cannabis</i> plant, can act as CBR agonists or antagonists, or ECS enzyme inhibitors, besides being able of playing a role in immune-mediated inflammatory and infectious diseases, neuroinflammatory, neurological, and neurodegenerative diseases, as well as in cancer, and autoimmunity by itself. In this review, we summarize and critically highlight past, present, and future progress on the understanding of the role of cannabinoid-like molecules, mainly terpenes, as prospective therapeutics for different pathological conditions.
Single Cell MicroRNA Analysis Using Microfluidic Flow Cytometry (2013)

MicroRNAs (miRNAs) are non-coding small RNAs that have cell type and cell context-dependent expression and function. To study miRNAs at single-cell resolution, we have developed a novel microfluidic approach, where flow fluorescent in situ hybridization (flow-FISH) using locked-nucleic acid probes is combined with rolling circle amplification to detect the presence and localization of miRNA. Furthermore, our flow cytometry approach allows analysis of gene-products potentially targeted by miRNA together with the miRNA in the same cells. We demonstrate simultaneous measurement of miR155 and CD69 in 12-O-tetradecanoylphorbol 13-acetate (PMA) and Ionomycin stimulated Jurkat cells. The flow-FISH method can be completed in ∼10 h, utilizes only 170 nL of reagent per experimental condition, and is the first to directly detect miRNA in single cells using flow cytometry.
Influence of Gamma Irradiation on Seedless Citrus Production: Pollen Germination and Fruit Quality (2011)

Seedlessness is a desirable characteristic in citrus fruits sold for fresh consumption. Gamma irradiation is widely used to obtain seedless citrus fruits. Here, different clones of the self-incompatible parthenocarpic ‘Moncada’ mandarin, obtained by gamma irradiation, were studied to assess seedlessness, pollen germination, fruit characteristics and qua- lity attributes. Findings indicate that irradiation altered aspects other than seedlessness, such as pollen germination, and some of the clones presented different weight, size, acidity and maturity index. Fruit quality and nutritional bio- components were affected differently; some clones presented no changes compared to the control ‘Moncada’ man-darin, while other clones showed significant differences. In general, all clones examined presented low seed numbers and re- duced pollen viability. Some of these clones, which ripen late in the season and whose fruit quality is maintained or improved, are in the process of registration.
Factors Associated with the Development of Neonatal Tolerance After the Administration of a Plasmid DNA Vaccine (1999)

A plasmid DNA vaccine encoding the circumsporozoite protein of malaria (pCSP) induces tolerance rather than immunity when administered to newborn mice. We find that this tolerance persists for >1 yr after neonatal pCSP administration and interferes with the induction of protective immunity in animals challenged with live sporozoites. Susceptibility to tolerance induction wanes rapidly with age, disappearing within 1 wk of birth. Higher doses of plasmid are more tolerogenic, and susceptibility to tolerance is not MHC-restricted. CD8+ T cells from tolerant mice suppress the in vitro Ag-specific immune response of cells from adult mice immunized with pCSP. Similarly, CD8+ T cells from tolerant mice transfer nonresponsiveness to naive syngeneic recipients. These findings clarify the cellular basis and factors contributing to the development of DNA vaccine-induced neonatal tolerance.
Laser-assisted modification of polymers for microfluidic, micro-optics, and cell culture applications (2007)

Laser-assisted patterning of polymers is investigated for the direct fabrication of polymeric lab-on-a-chip devices in microsystem technology for capillary electrophoresis chips in bio-analytical applications. In many cases the laser process induces a chemical, physical and topographical change in the laser treated surface. This material modification significantly influences the lab-on-a-chip-functionalities. We will present our current research results in laser-assisted modification of polystyrene (PS) and polymethylmethacrylate (PMMA) with respect to applications in micro-optics, micro-fluidics and cell culture applications. For this purpose the refractive index change, the wettability and the adsorption of proteins and the adhesion of animal cells were investigated as function of laser- and processing parameters. The possible change of surface chemistry was characterized by X-ray photoelectron spectroscopy. The local UV-laser-assisted formation of chemical structures suitable for improved cell adhesion was realized on two- and three-dimensional PS and polycarbonate (PC) surfaces. Above and below the laser ablation threshold two different mechanisms were detected. In one case the produced debris was responsible for improved cell adhesion, while in the other case a photolytical activation of the polymer surface including a subsequent oxidization in oxygen or ambient air leads to a highly localized alteration of protein adsorption from cell culture media and increased cell adhesion. The highly localized control of wettability on polymeric surfaces was investigated for PS and PMMA. In the case of PS the dynamic advancing contact angle could be adjusted between 2° and 150°. This was possible for a suitable exposure dose and an appropriate choice of processing gas (helium or oxygen). A similar but not so significant effect was observed for PMMA below the laser ablation threshold. For PMMA the dynamic advancing contact angle could be adjusted between nearly 50° and 80°. The adjustment of wettability for microfluidic application will be discussed. For the integration of integrated optical waveguides in micro-fluidic devices new approaches for a rapid manufacturing of optical singlemode waveguides made of PMMA were investigated. For this purpose a high repetition excimer laser radiation source was used in combination with a flexible mask technology. The waveguides were characterized for the visible optical range and for 1559 nm. The obtained structures reveal absorption losses of 0.7 dB/cm in the visible range.
<i>C</i>-(2-Hydroxyaryl)-<i>N</i>-(2-hydroxyphenylmethyl)nitrones as regioselective bidentate ligands in boron chelate formation. Crystal and molecular structures of a diphenylboron complex and its parent ligand (1998)

The C-(2-hydroxyaryl)-N-(2-hydroxyphenylmethyl)nitrones 5 are synthesized by the condensation of variously substituted salicylaldehydes with N-(2-hydroxyphenylmethyl)-hydroxylamine. These nitrones react with diphenylborinic acid anhydride to form seven-membered diphenylboron chelates 6. Crystals of C-(4-diethylamino-2-hydroxyphenyl)-N-(2-hydroxyphenylmethyl)nitrone, 5d, are monoclinic, a = 6.911(2), b = 10.663(2), c = 22.951(1) Å, β = 97.33(1)°, Z = 4, space group P21/n, and those of 4-dimethylamino-8-(2-hydroxyphenylmethyl)-6,6-diphenyl-5,7-dioxa-8-azonia-6-borata-6,7-dihydro-5H-benzocycloheptene-ethanol, 6d·EtOH, are monoclinic, a = 9.069(2), b = 29.881(1), c = 11.1883(6) Å, β = 109.426(9)°, Z = 4, space group P21/n. The structures were solved by direct methods and refined by full-matrix least-squares procedures to R = 0.032 and 0.039 (R w = 0.031 and 0.036) for 2510 and 4162 reflections with I > 3σ(I), respectively. Key words : C-(2-hydroxyaryl)-N-(2-hydroxyphenylmethyl)nitrones, organoboron compounds, crystal structures.
Determinants of renal vascular resistance in the Dahl strain of genetically hypertensive rat. (1980)

Hypertension-resistant (R) rats of the Dahl strain remain normotensive on diets containing excessive sodium chloride, while hypertension-sensitive (S) rats rapidly become hypertensive when eating the same diet. In the present study, renal hemodynamics were investigated in Dahl rats eating normal or high salt chow for 4 weeks. The R rats eating sodium-enriched chow were found to have significantly lower renal vascular resistance (RVR) than R rats on normal chow; RVR was identical in S rats on either diet. The reason for the failure of S kidneys to exhibit vasodilation during high salt ingestion was explored by examining renal vascular responses to interruption of the renal sympathetic nerves, renal sympathetic nerve stimulation (SNS), and to several vasoactive agents. Changes in RVR to nerve section and to SNS were similar in both strains regardless of diet. Renal vascular responses to intraarterial norepinephrine were suppressed significantly by high salt intake only in the R rats. Changes in RVR to intraarterial angiotensin II were uniformly greater in S than in R rats, but were not altered by salt intake in either strain. Renal vasodilation in response to intraarterial acetylcholine was reduced in R rats on high salt intake, but was not affected by salt intake in S rats. It is concluded that S rats exhibit inappropriately high renal vascular tone during ingestion of excessive salt, and that this alteration is not the result of increased neurogenic activity or increased vascular reactivity to angiotensin II or norepinephrine.
Protecting cache memories through data scrambling technique (2014)

Increasing the security of memory systems is relevant due to the sensitive information which is stored in plain-text. Over the last decade, device specific attacks have been reported as being successfully in retrieving encryption and private keys from AES algorithms. A novel technique is proposed in this work, which improves the security of a cache memory through the use of data scrambling. Several dissemination rules are explained and employed, in order to make the proposed method a viable security solution. The proposed technique is evaluated from several points of view (area overhead, power consumption and performance) and compared to a standard technique.
Lysobactin, a novel antibacterial agent produced by Lysobacter sp. II. Biological properties. (1988)

Lysobactin, an antibiotic isolated from a strain of Lysobacter, is 2 to 4-fold more active than vancomycin against aerobic and anaerobic Gram-positive bacteria. Included in the spectrum of lysobactin are Staphylococci, Streptococci, corynebacteria, clostridia and various other Gram-positive anaerobic bacteria. The activity of lysobactin against aerobic and anaerobic Gram-negative bacteria is poor. When given parenterally the compound was efficacious in systemic staphylococcal and streptococcal infections in mice. Similarly, when applied topically lysobactin was also curative in a staphylococcal wound infection in mice. Some studies on the mode of action of lysobactin are presented.
High-Performance and Dynamically Updatable Packet Classification Engine on FPGA (2015)

High-performance and dynamically updatable hardware architectures for multi-field packet classification have regained much interest in the research community. For example, software defined networking requires 15 fields of the packets to be checked against a predefined rule set. Many algorithmic solutions for packet classification have been studied over the past decade. FPGA-based packet classification engines can achieve very high throughput; however, supporting dynamic updates is yet challenging. In this paper, we present a two-dimensional pipelined architecture for packet classification on FPGA; this architecture achieves high throughput while supporting dynamic updates. In this architecture, modular Processing Elements (PEs) are arranged in a two-dimensional array. Each PE accesses its designated memory locally, and supports prefix match and exact match efficiently. The entire array is both horizontally and vertically pipelined. We exploit striding, clustering, dual-port memory, and power gating techniques to further improve the performance of our architecture. The total memory is proportional to the rule set size. Our architecture sustains high clock rate even if we scale up (1) the length of each packet header, or/and (2) the number of rules in the rule set. The performance of the entire architecture does not depend on rule set features such as the number of unique values in each field. The PEs are also self-reconfigurable; they support dynamic updates of the rule set during run-time with very little throughput degradation. Experimental results show that, for a 1 K 15-tuple rule set, a state-of-the-art FPGA can sustain a throughput of 650 Million Packets Per Second (MPPS) with 1 million updates/second. Compared to TCAM, our architecture demonstrates at least four-fold energy efficiency while achieving two-fold throughput.