gebhart/patrepeval huggingface dataset:
L-TYPE AMINO ACID TRANSPORTER 1 EXPRESSION IN PROSTATE CANCER: ASSOCIATION WITH CANCER PROGRESSION AND HIGH-GRADE MALIGNANCY (2008)

You have accessJournal of Urology1 Apr 2008L-TYPE AMINO ACID TRANSPORTER 1 EXPRESSION IN PROSTATE CANCER: ASSOCIATION WITH CANCER PROGRESSION AND HIGH-GRADE MALIGNANCY Takefumi Satoh, Takeshi Sakata, Isao Okayasu, Golam Ferdous, Tomoko Tsuruta, Tomoko Muto, Akinori Ueno, Yoshikatsu Kanai, Hitoshi Endou, and Shiro Baba Takefumi SatohTakefumi Satoh More articles by this author , Takeshi SakataTakeshi Sakata More articles by this author , Isao OkayasuIsao Okayasu More articles by this author , Golam FerdousGolam Ferdous More articles by this author , Tomoko TsurutaTomoko Tsuruta More articles by this author , Tomoko MutoTomoko Muto More articles by this author , Akinori UenoAkinori Ueno More articles by this author , Yoshikatsu KanaiYoshikatsu Kanai More articles by this author , Hitoshi EndouHitoshi Endou More articles by this author , and Shiro BabaShiro Baba More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60306-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "L-TYPE AMINO ACID TRANSPORTER 1 EXPRESSION IN PROSTATE CANCER: ASSOCIATION WITH CANCER PROGRESSION AND HIGH-GRADE MALIGNANCY." The Journal of Urology, 179(4S), p. 105 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 105 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Takefumi Satoh More articles by this author Takeshi Sakata More articles by this author Isao Okayasu More articles by this author Golam Ferdous More articles by this author Tomoko Tsuruta More articles by this author Tomoko Muto More articles by this author Akinori Ueno More articles by this author Yoshikatsu Kanai More articles by this author Hitoshi Endou More articles by this author Shiro Baba More articles by this author Expand All Advertisement PDF downloadLoading ...
Health-Dev: Model Based Development Pervasive Health Monitoring Systems (2012)

Implementing requirements verified body worn medical sensors and smart phones, acting as base stations, in Body Sensor Networks (BSNs), is of extreme importance for development of reliable pervasive health monitoring systems (PHMS). Models of BSNs have been used to analyze designs with respect to requirements such as energy consumption, lifetime, and network reliability under dynamic context changes due to user mobility. This paper proposes Health-Dev that takes a high level specification of requirements verified BSN design and automatically generates both the sensor and smart phone code. Case studies related to energy efficiency and mobility aware network reliability show whether the resulting implementation satisfies the requirements set forth in the design phase.
Fast-switching frequency-converted laser light source for display applications (2010)

We report a passively Q-switched two-component visible laser light source based on frequency conversion. The device consists of a monolithic single transverse mode ridge-waveguide infrared laser diode and a waveguide-type periodically poled magnesium oxide doped lithium niobate crystal for second harmonic light generation. An integrated 45-degree folding mirror and a coupling lens are formed by etching on opposite sides of the monolithic gallium arsenide -based laser diode for coupling the infrared emission into the waveguide-type nonlinear crystal for efficient single pass frequency conversion. Passively Q-switched operation is realized by an integrated electro-absorber section coupled with the in-plane multi-quantum well gain structure. Stable high-repetition rate self-pulsating operation was achieved by reverse-biasing the electro-absorber section and reduced speckle visibility of the second harmonic light was observed when compared to continuous-wave operation of the same laser.
Iris boundaries segmentation using the generalized structure tensor. A study on the effects of image degradation (2012)

We present a new iris segmentation algorithm based on the Generalized Structure Tensor (GST), which also includes an eyelid detection step. It is compared with traditional segmentation systems based on Hough transform and integro-differential operators. Results are given using the CASIA-IrisV3-Interval database. Segmentation performance under different degrees of image defocus and motion blur is also evaluated. Reported results shows the effectiveness of the proposed algorithm, with similar performance than the others in pupil detection, and clearly better performance for sclera detection for all levels of degradation. Verification results using 1D Log-Gabor wavelets are also given, showing the benefits of the eyelids removal step. These results point out the validity of the GST as an alternative to other iris segmentation systems.
Vasoregulatory function of the heme-heme oxygenase-carbon monoxide system (2001)

Arterial vessels express one or more heme oxygenase (HO) isoenzymes that catalyze the metabolism of heme to carbon monoxide (CO) and biliverdin. Carbon monoxide promotes vasorelaxation through mechanisms that, depending on the vessels, involve activation of soluble guanylate cyclase, stimulation of calcium-activated potassium channels, or diminished synthesis of constrictor mediators, such as, endothelin and 20-HETE. Inhibitors of HO elicit vasoconstriction in vivo and in isolated pressurized arterioles. Inhibitors of HO also enhance myogenic vasoconstriction, as well as the constriction induced by phenylephrine in several vessels. The blood pressure of awake rats is increased by acute treatment with HO inhibitors, a response that is accompanied by attenuation of baroreflex activity. All in all, it would appear that a product of HO activity manufactured by arterial vessels, presumably CO, promotes vasodilation and decreases the reactivity of vascular smooth muscle to myogenic stimuli and constrictor agonists. In doing so, CO of vascular origin may contribute to the implementation of antihypertensive mechanisms. Carbon monoxide produced in central nervous system structures, for example, the nucleus tractus solitarii, also appears to support a blood pressure-lowering mechanism linked to inhibitory modulation of baroreceptor reflex activity.
Blood Glucose-Lowering Activity of a Hyaluronan–Insulin Complex After Oral Administration to Rats with Diabetes (2005)

Background: Several covalently modified insulin derivatives or formulations with absorption enhancers have been shown to decrease the blood glucose concentration after oral administration in animals with diabetes. The aim of this study was to investigate the biological activity of a novel hyaluronan–insulin complex. Methods: The efficacy of the complexed insulin after oral and subcutaneous administration was evaluated by analysis of blood glucose concentrations in rats with streptozotocin-induced diabetes. Results: The complexed insulin significantly decreased blood glucose concentrations within 1 h after oral administration in eight of 10 rats in the dose interval 1.5–4.7 mg (3.1–14.5 mg/kg). Oral administration of native insulin or non-complexed insulin plus hyaluronan using similar doses failed to decrease blood glucose concentrations. The lowest oral dose of complexed insulin achieving a statistically significant decrease in blood glucose concentrations was 1.2–1.5 mg (about 4 mg/kg), and the threshold dose after subcutaneous administration was 0.08–0.12 mg (0.25 mg/kg). Conclusions: The hyaluronan–insulin complex was active after oral administration and decreased blood glucose concentrations in rats with streptozotocin-induced diabetes. The ratio between the oral and subcutaneous threshold doses was about 16.
Mutations in the fukutin-related protein gene (FKRP) identify limb girdle muscular dystrophy 2I as a milder allelic variant of congenital muscular dystrophy MDC1C (2001)

The limb girdle and congenital muscular dystrophies (LGMD and CMD) are characterized by skeletal muscle weakness and dystrophic muscle changes. The onset of symptoms in CMD is within the first few months of life, whereas in LGMD they can occur in late childhood, adolescence or adult life. We have recently demonstrated that the fukutin-related protein gene (FKRP) is mutated in a severe form of CMD (MDC1C), characterized by the inability to walk, leg muscle hypertrophy and a secondary deficiency of laminin alpha2 and alpha-dystroglycan. Both MDC1C and LGMD2I map to an identical region on chromosome 19q13.3. To investigate whether these are allelic disorders, we undertook mutation analysis of FKRP in 25 potential LGMD2I families, including some with a severe and early onset phenotype. Mutations were identified in individuals from 17 families. A variable reduction of alpha-dystroglycan expression was observed in the skeletal muscle biopsy of all individuals studied. In addition, several cases showed a deficiency of laminin alpha2 either by immunocytochemistry or western blotting. Unexpectedly, affected individuals from 15 families had an identical C826A (Leu276Ileu) mutation, including five that were homozygous for this change. Linkage analysis identified at least two possible haplotypes in linkage disequilibrium with this mutation. Patients with the C826A change had the clinically less severe LGMD2I phenotype, suggesting that this is a less disruptive FKRP mutation than those found in MDC1C. The spectrum of LGMD2I phenotypes ranged from infants with an early presentation and a Duchenne-like disease course including cardiomyopathy, to milder phenotypes compatible with a favourable long-term outcome.
Genomic Mismatch Scanning Identifies Human Genomic DNA Shared Identical by Descent (1998)

Genomic mismatch scanning (GMS) is a high-throughput, high-resolution identity by descent mapping technique that enriches for genomic DNA fragments that are shared between related individuals. In GMS, DNA heteroduplexes are formed from restriction-digested genomic DNA fragments from two relatives. Mismatch-free DNA heteroduplexes, likely representing DNA shared identical by descent between the two individuals, are relatively purified by depleting the mismatch-containing heteroduplexes using the Escherichia coli mismatch repair proteins and exonuclease. Here, we demonstrate using quantitative microsatellite genotyping that, despite the complexity of the human genome, GMS can enrich the majority of restriction fragments that are identical by descent between two related humans. As the entire genome is selected in GMS, an extraordinarily dense set of markers (up to 200,000 markers) may be screened in parallel. The demonstration of the molecular enrichment of identical DNA fragments in the context of the whole human genome establishes conditions for the application of GMS to human genetics. This forms a frame-work for the further development of GMS as a hybridization-based mapping technique that utilizes DNA microarray technology to map the selected identical by descent DNA fragments.
An Efficient GPS Position Determination Algorithm (2003)

ABSTRACT: A direct, closed-form and efficient new position determination algorithm that exploits the closed-form solution of the GPS trilateration equations and works in the presence of pseudorange measurement noise and for an arbitrary number of satellites in view is developed. A two-step GPS position determination algorithm that (1) entails the solution of a linear regression and (2) updates the solution based on one nonlinear measurement equation is derived. In step 2, only two or three iterations are required, as opposed to the five iterations that are normally required in the standard iterative least-squares (ILS) algorithm currently used. The mathematically derived stochastic modeling – based solution algorithm for the GPS pseudorange equations is assessed and compared with the conventional ILS algorithm. Good estimation performance is achieved even under high geometric dilution of precision (GDOP) conditions.
Floating-gates transistors for precision analog circuit design: an overview (2005)

This paper presents an overview of floating-gate transistors with an emphasis on using them as programmable elements to correct mismatch inherent in analog circuit design. The design methodology is such that floating-gate MOSFETs play the role of programmable elements while forming an inherent part of the circuitry of interest, as well. Such an approach results in a compact architecture with minimal additional power. Accurate programming that is key to a successful implementation is discussed along with experimental results demonstrating floating-gate charge retention. An overview of several circuit design examples is provided to demonstrate the feasibility of using floating-gate transistors for precision analog circuit design
Biochemical and Molecular Characterization of Hereditary Myeloperoxidase Deficiency (1997)

Hereditary myeloperoxidase (MPO) deficiency is a neutrophil disorder characterized by the lack of peroxidase activity. Cytochemical, biochemical, spectroscopic, immunocytochemical, and genetic studies were carried out on a 5-year-old MPO-deficient subject and on her parents. The father was also MPO-deficient, whereas the mother had 24% of normal MPO activity. Although the typical absorption spectrum of MPO was absent in both the father and daughter, the father's neutrophils, and not those of the daughter, contained material antigenically related to MPO. In the MPO gene of the father, two mutations were found, each located in a different allele: a T --> C transition, causing the nonconservative replacement M251T and a 14-base deletion within exon 9. The M251T substitution occurred in the carboxy-terminal region of the light chain that is included in the heme pocket. The daughter inherited the 14-base deletion from her father. The study of the MPO mRNAs present in liquid cultures of granulocyte precursors surprisingly showed that the same genetic defect, ie, the 14-base deletion, seemed to exhibit different mRNA phenotypes in the father and the daughter. In fact, mRNA derived from the 14-base-deleted allele was not found in the father and an aberrantly spliced MPO mRNA with a 77-base deletion of exon 9, which includes the 14-base deletion and leads to the generation of a premature stop codon, was found in the daughter. The possibility that Delta77 mRNA could derive from other mutations linked to the Delta14 allele was dismissed because no sequence differences were found in the region (exons and exon-intron junctions). Our data indicate that the alteration of the mRNA context caused by the 14-base deletion provide a basis for the 77-base deletion in the mRNA processing. Since the granulocyte precursors from the liquid cultures of the father were more differentiated than those from the daughter, the observed different behavior of the 14-base-deleted allele in the father and daughter may be the result of a differentiation-stage dependent control of altered spliced mRNA, which may be tolerated during the early stages of differentiation but degraded at later stages. In the liquid cultures of the daughter's cells, in addition to the mRNA with the 77-base deletion, a mRNA with the wild type sequence was also found. This mRNA was inherited from the mother, since no mutations were found in her MPO cDNA and MPO gene. The MPO defect might be caused by a regulatory mutation that induces the MPO gene switch off at an early stage of granulocyte differentiation.
Controlled Release Pulmonary Administration of Curcumin Using Swellable Biocompatible Microparticles (2011)

This study involves a promising approach to achieve sustained pulmonary drug delivery. Dry powder particulate carriers were engineered to allow simultaneous aerosol lung delivery, evasion of macrophage uptake, and sustained drug release through a controlled polymeric architecture. Chitosan grafted with PEG was synthesized and characterized (FTIR, EA, DSC and 2D-XRD). Then, a series of respirable amphiphilic hydrogel microparticles were developed via spray drying of curcumin-loaded PLGA nanoparticles with chitosan-grafted-PEG or chitosan. The nanoparticles and microparticles were fully characterized using an array of physicochemical analytical methods including particle size, surface morphology, dynamic swelling, density, moisture content and biodegradation rates. The PLGA nanoparticles and the hydrogel microspheres encapsulating the curcumin-loaded PLGA nanoparticles showed average size of 221-243 nm and 3.1-3.9 μm, respectively. The developed carriers attained high swelling within a few minutes and showed low moisture content as dry powders (0.9-1.8%), desirable biodegradation rates, high drug loading (up to 97%), and good sustained release. An aerosolization study was conducted using a next generation impactor, and promising aerosolization characteristics were shown. In vitro macrophage uptake studies, cytotoxicity and in vitro TNF-α assays were performed for the investigated particles. These assays revealed promising biointeractions for the respirable/swellable nano-micro particles developed in this study as potential carriers for sustained pulmonary drug delivery.
Volume 4, Issue 1 (2013)

<div><em>This issue showcases a rich variety of first year issues reported from an assortment of national and international settings.  In the Feature, Professor Phil Long (University of Queensland) and Associate Professor Shane Dawson (University of South Australia) share their views about the issues and challenges associated with learning analytics.  Reflecting the adage from last century that successful student engagement is the result of a combination of warmth and challenge the articles and practice reports focus on both the cognitive challenge  (e.g., assessment, forms of knowledge, distance learning, research skills, peer learning, etc.) and the affective warmth (e.g., help-seeking, collaboration, identity development etc.) aspects of student behaviour.</em></div><div><br /></div>
Multicenter Validation of an <scp>MMSE</scp> ‐Mo <scp>CA</scp> Conversion Table (2017)

In this study, we validated a conversion table between MMSE and MoCA using a large multicenter sample. Our results suggest caution in interpreting the tables in heterogeneous clinical populations, as the MMSE-MoCA relationship may be different across dementia subtypes.
Pattern design criteria of main circuit using printed circuit boards for parasitic inductance reduction (2014)

This paper investigates differences of parasitic inductances caused by DC bus bar patterns on printed circuit boards(PCB). The DC bus bar pattern on the PCB is limited depending on the layout of main circuits and the control circuits. Two patterns which are a laminated wiring pattern and a plane wiring pattern are compared in experiments and simulations. In this paper, it will be clarified that effects of the DC bus bars on PCBs such as a surge voltage of a switch in terms of the parasitic inductance depending on the circuits on PCBs. As a result, if the same parasitic inductance which is 20 nH, is realized between each wiring pattern at the same length, the plane wiring pattern requires over ten times of the pattern width compared with that of the laminated wiring pattern. Hence, the circuit size can be downsized when the laminated pattern is used. From the experimental results, the maximum surge voltage in the plane wiring pattern is larger than that in the laminated wiring pattern. In this case, the parasitic inductance value of the plane wiring pattern is three times that of the laminated wiring pattern. However, the surge voltage in the laminated pattern is reduced by 7% compared with the plane wiring pattern. As a consequence, the ratio of the surge voltage does not match that of the parasitic inductance. As a result, not only the parasitic inductance of the DC bus bar but also it is necessary to consider other parasitic inductances on PCBs such as parasitic inductances into input capacitors and the path between an upper MOSFET and a lower one and so on.
Cylindrical manifolds and tube dynamics in the restricted three-body problem (2004)

Within the phase space of the planar circular restricted three-body problem, stable and unstable manifolds of periodic orbits with a S x R (cylindrical) geometry are shown to exist. The periodic orbits considered reside in bottleneck regions of the energy manifold, separating large zones associated with motion about one mass, the other mass, or both masses.

The cylinders have the physical property that all motion through the bottleneck in which the periodic orbit resides must occur through the interior of these surfaces. The cylinders thus mediate the global transport of test particles between large zones of the energy surface which are separated by the bottlenecks.

By elucidating the structuring role of the cylinders, we provide a new language for discussing some important problems in celestial mechanics. Furthermore, we propose that these cylindrical structures are the natural objects of study for the design of space mission trajectories which take advantage of three-body effects.
연구개발비와 초과이익간의 상관성이 가치평가에 미치는 영향 (2004)

본 연구에서는 손익계산서상 비용처리된 연구개발지출에 대한 가치평가를 분석하였다. 이익지속성을 초과이익의 1차자기상관계수로 정의할 때 연구개발지출이 당기 또는 차기 초과이익에 미치는 영향에 따라서 동 연구개발지출에 대한 주가배수가 달라지는지의 여부를 검토하였다. 구체적으로 Ohlson(1995) 모형의 초과이익에 관한 선형정보식으로부터 t년도 연구개발지출과 t+1년도(t년도) 초과이익간의 시차상관성(동시상관성)이 높을수록 이익지속성이 감소(증가)한다는 관계를 도출하고, 이에 따라 현행 회계원칙 하에서 비용처리된 연구개발지출의 시차상관성(동시상관성)이 높을수록 그에 대한 주가배수는 커(작아)진다는 가설을 검증하였다. 1993년부터 2001년 사이에 증권거래소에 상장된 금융업에 속하지 않는 275개 12월 결산법인(1,426개 기업-년)을 대상으로 실증분석을 수행하였다. 분석결과에 의하면 가설의 예측대로 t년도 연구개발지출이 t+1년도 초과이익에 미치는 영향, 즉 시차상관성이 클수록 동 연구개발지출에 대한 주가배수는 증가하는 것으로 나타났다. 또한 t년도 연구개발지출이 t년도 초과이익에 미치는 영향, 즉 동시상관성이 클수록 동 연구개발지출에 대한 주가배수는 감소하는 것으로 나타났다. 이는 연구개발지출이 미래수익창출에 공헌하는지에 따라 비용처리하거나 또는 자산화후 상각처리하는 것이 이익지속성 및 가치관련성에 유의한 영향을 미친다는 증거로 해석된다. 이상의 결과는 연구개발지출의 회계처리방법을 논의함에 있어서 두 가지의 시사점을 제시하고 있다. 첫째는 미래수익을 성공적으로 창출하는 경우와 그렇지 않은 경우를 구분할 필요가 있다는 점이다. 둘째는 구분된 연구개발지출에 대하여 차별적으로 회계처리하는 방안을 고려하는 것이 수익·비용 대응을 향상시킨다는 점이다. 이와 같은 문제에 초점을 맞춤으로써 궁극적으로 회계정보의 가치관련성을 제고할 수 있을 것이다.
CHAP. II (2011)

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Artifact removal in Fourier-domain optical coherence tomography with a piezoelectric fiber stretcher (2008)

We describe an artifact removal setup swept-source optical coherence tomography (OCT) system that enables high-speed full-range imaging. We implement a piezoelectric fiber stretcher to generate a periodic phase shift between successive A-scans, thus introducing a transverse modulation. The depth ambiguity is then resolved by performing a Fourier filtering in the transverse direction before processing the data in the axial direction. The dc artifact is also removed. The key factor is that the piezoelectric fiber stretcher can be used to generate discrete phase shifts with a high repetition rate. The proposed experimental setup is a much improved version of the previously reported B-M mode scanning for spectral-domain OCT in that it does not generate additional artifacts. It is a simple and low-cost solution for artifact removal that can easily be applied.