gebhart/patrepeval huggingface dataset:
Effect Of Biomass Generated Producer Gas, Methane And Physical Parameters On Producer Gas Fermentations By Clostridium Strain P11 (2014)

The effect of producer gas generated by gasification of Kanlow switchgrass was determined to investigate the robustness of Clostridium strain P11 for the integration of gasification-fermentation process in a lab scale. Further experiments were performed for determining the effect of 5% methane, as methane is a major component of producer gas generated through gasification. Effect of 1.63% oxygen that was present in corn gluten feed (CGF) producer gas was also determined. Furthermore, the effect of physical parameters such as heat shocking, agitation and headspace gas (amount of available gas) were determined for enhancing the solvent concentrations and productivities. Findings and Conclusions: The use of switchgrass producer gas generated from fluidized bed gasifier showed an increase in ethanol concentrations by 125%, decrease in acetic acid concentrations by 40% and production of isopropanol at concentrations as high as 3.9 g/l. Producer gas components such as tars, nitric oxide and hydrocarbons could possibly be responsible for the metabolic shifts. 5% methane did not affect growth, product formation and gas uptake in P11 fermentation indicating that methane was an inert component of producer gas. However, the presence of 1.63% oxygen was highly toxic to P11 cells as it inhibited growth, product formation and gas uptake rates. Also, acetone that was used in gas-clean up was found to be contaminant of producer gas in the CGF experiment as it was getting accumulated in the culture media. Increasing agitation rates inhibited product formation possibly due to the shear sensitivity of P11. Heat shocking at 92�C improved the percentage of gas (CO and H 2 ) utilization, yields of ethanol and acetic acid, ethanol productivity when compared to cells that were heat shocked at 75�C and the cells that were not heat treated. By increasing the headspace gas, cell mass and ethanol concentrations increased by 160% and 181% respectively and the ethanol productivity increased by 865% when compared to the cells that were grown with the normal headspace.
Increased human immunodeficiency virus (HIV) expression in chronically infected U937 cells upon in vitro differentiation by hydroxyvitamin D3: roles of interferon and tumor necrosis factor in regulation of HIV production (1990)

We have investigated the roles of cytokines in the modulation of human immunodeficiency virus (HIV) production in chronically infected U937 cells upon in vitro differentiation by hydroxyvitamin D3. HIV-infected U937 cells exhibited markedly lower levels of CD4 and HLA-DR antigens than uninfected cells did. Vitamin D3 induced a time-dependent macrophagelike differentiation, as determined by monitoring the expression of some surface antigens by means of the monoclonal antibodies OKM1, OKM5, OKM13, OKM14, OKT4, anti-HLA-DR, TecMG2, TecMG3, LeuM3, LeuM1, anti-HLA-DP, and anti-HLA-DQ. Treatment with hydroxyvitamin D3 resulted in a marked increase in HIV production compared with control cultures. Interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) were detected in the culture media, whereas interferon (IFN) was not generally found. Using the polymerase chain reaction technique, we found HIV-infected U937 cells to express detectable levels of mRNAs for alpha interferon (IFN-alpha), IFN-beta, TNF-alpha, and IL-1 beta. The addition of TNF resulted in a marked increase of HIV production, whereas IL-1 beta was ineffective. In contrast, both IFN-alpha and IFN-beta exerted some inhibitory effect on HIV production, which was more marked in vitamin D3-treated cultures than in untreated cultures. HIV production was significantly increased by antibodies to IFN-alpha in both untreated and vitamin D3-treated cultures. Anti-IFN-beta antibody increased HIV production only in vitamin D3-treated cells. In contrast, anti-TNF-alpha antibodies markedly decreased HIV production in both control and differentiating U937 cells. Vitamin D3 treatment resulted in a higher expression of TNF receptors in differentiating cells than in control HIV-infected cells. These data demonstrate a strong correlation between HIV production and macrophagelike differentiation in chronically infected U937 cells and suggest that endogenous IFN and TNF exert opposite effects in the regulation of virus production in both undifferentiated and vitamin D3-treated cell cultures.
Structure−Affinity Relationship Study on <i>N</i>-[4-(4-Arylpiperazin-1-yl)butyl]arylcarboxamides as Potent and Selective Dopamine D<sub>3</sub> Receptor Ligands (2002)

The benzamide PB12 (N-[2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide) (1), already reported as potent and selective dopamine D(4) receptor ligand, has been modified searching for structural features that could lead to D(3) receptor affinity. Changes in the aromatic ring linked to N-1 piperazine ring led to the identification of 2-methoxyphenyl and 2,3-dichlorophenyl derivatives (compounds 6 and 13) displaying moderate D(3) affinity (K(i) = 145 and 31 nM, respectively). Intermediate alkyl chain elongation in compounds 1, 6, and 13 improved binding affinity for the D(3) receptor and decreased the D(4) affinity (compounds 18-26). Among these latter compounds, the N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-3-methoxybenzamide (19) was further modified with the replacement or of the 2,3-dichlorophenyl moiety (compounds 27-30) or of the 3-methoxyphenyl ring (compounds 31-41). In this way, we identified several high-affinity D(3) ligands (0.13 nM < K(i)'s < 4.97 nM) endowed with high selectivity over D(2), D(4), 5-HT(1A), and alpha(1) receptors. In addition, N-[4-[4-(2,3-dimethylphenyl)piperazin-1-yl]butyl]-3-methoxybenzamide (27) and N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-7-methoxy-2-benzofurancarboxamide (41) appear to be valuable candidates for positron emission tomography (PET) because of their affinity values, lipophilicity properties, and liability of (11)C labeling in the O-methyl position.
Building a Technology-Using Faculty to Facilitate Technology-Using Teachers (1995)

AbstractThe faculty and dean of the College of Education at the University of Nebraska at Omaha identified educational technology as a major goal eight years ago. This goal was divided into teaching about technology, teaching with educational technology, integrating technology into curricula, and engaging in research regarding technology in the teaching/learning process.In order to meet this goal, the college developed a plan, which addresses three important areas; equipment for faculty, staff, and students; training of faculty in the educational and personal uses of computer-related technology; and expectations that technology be an integral part of the academic activities of the faculty. This article overviews the literature related to technology use in teacher education programs, explains the UNO plan, and reports the results of the plan to date.
Coexpression of IL7 and CCL21 Increases Efficacy of CAR-T Cells in Solid Tumors without Requiring Preconditioned Lymphodepletion (2020)

Coexpression of IL7 and CCL21 could boost CAR-T cells' antitumor activity, and 7 × 21 CAR-T cells may be served as a promising therapy strategy for solid tumors.
In vivo evaluation of polyurethanes based on novel macrodiols and MDI (1995)

A series of novel polyurethane elastomers based on methylenediphenyl diisocyanate, 1,4-butanediol and the macrodiols, poly(hexamethylene oxide), poly(octamethylene oxide), and poly(decamethylene oxide) were implanted subcutaneously in sheep for periods of 3 and 6 months. The specimens that were subjected to 3 months of implantation were strained to 250% of their resting length, while those implanted for 6 months had no applied external strain. SEM examination of the explanted specimens revealed that the novel materials displayed resistance to environmental stress cracking. Proprietary materials, Pellethane 2363-80A, Biomer and Tecoflex EG-80A, which had been implanted under identical conditions, showed evidence of significant stress cracking. The extent of stress cracking in the 3-month strained experiment was similar to that from the 6-month unstrained experiment. Stress cracking was also observed in Pellethane 2363-55D, when implanted for 6 months (unstrained). Neither changes in molecular weight nor in tensile properties provided a clear indication of early susceptibility to degradation by environmental stress cracking.
Fast Sleep Spindle (13–15 Hz) Activity Correlates with Sleep-Dependent Improvement in Visuomotor Performance (2008)

The thalamocortical network underlying fast-spindle generation may contribute to or reflect plasticity during sleep.
An Improved Synthesis of Oxytocin<sup>1</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Improved Synthesis of Oxytocin1Miklos Bodanszky and Vincent du VigneaudCite this: J. Am. Chem. Soc. 1959, 81, 10, 2504–2507Publication Date (Print):May 1, 1959Publication History Published online1 May 2002Published inissue 1 May 1959https://pubs.acs.org/doi/10.1021/ja01519a053https://doi.org/10.1021/ja01519a053research-articleACS PublicationsRequest reuse permissionsArticle Views207Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Guanidinoacetate methyltransferase (GAMT) deficiency: Outcomes in 48 individuals and recommendations for diagnosis, treatment and monitoring (2013)

We collected data on 48 patients from 38 families with guanidinoacetate methyltransferase (GAMT) deficiency. Global developmental delay/intellectual disability (DD/ID) with speech/language delay and behavioral problems as the most affected domains was present in 44 participants, with additional epilepsy present in 35 and movement disorder in 13. Treatment regimens included various combinations/dosages of creatine-monohydrate, l-ornithine, sodium benzoate and protein/arginine restricted diets. The median age at treatment initiation was 25.5 and 39 months in patients with mild and moderate DD/ID, respectively, and 11 years in patients with severe DD/ID. Increase of cerebral creatine and decrease of plasma/CSF guanidinoacetate levels were achieved by supplementation with creatine-monohydrate combined with high dosages of l-ornithine and/or an arginine-restricted diet (250 mg/kg/d l-arginine). Therapy was associated with improvement or stabilization of symptoms in all of the symptomatic cases. The 4 patients treated younger than 9 months had normal or almost normal developmental outcomes. One with inconsistent compliance had a borderline IQ at age 8.6 years. An observational GAMT database will be essential to identify the best treatment to reduce plasma guanidinoacetate levels and improve long-term outcomes.
II. Photochemistry of azobenzene and its derivatives (1972)

The first page of this article is displayed as the abstract.
Secretory immunological response after intranasal inactivated influenza A virus vaccinations: evidence for immunoglobulin A memory (1983)

An intranasal, inactivated trivalent influenza A vaccine containing 7 micrograms of A/Bangkok/1/79 (H3N2) hemagglutinin was administered to 20 children aged 1 to 6 years to assess the local and systemic immune responses to antigen delivered to the respiratory tract. Six children without prior influenza virus infection exhibited no local immune response and manifested only a minimal systemic response to the intranasal vaccine. In contrast, five individuals who were previously infected with a live attenuated influenza A H3N2 virus vaccine, although having no residual secretory antibody at the time of challenge, promptly developed a local antibody response to intranasal, inactivated antigen. Therefore, the live influenza A virus vaccine had induced memory in the local immunoglobulin A (IgA) immune system. The third group of nine children had previously been infected with wild-type H3N2 influenza virus. A majority of these children had residual local and systemic antibody at the time of challenge but they demonstrated some boosting of local IgA antibody with administration of intranasal inactivated vaccine. The competence of the secretory IgA immune system in young children in mounting primary and secondary responses to influenza antigens has important implications for approaches to prevention of influenzal illness.
Front Matter (2015)

Volume 13, Nomor 2, Desember 2015
Endotoxin Enhanced Adjuvant Effect of Liposomes, Particularly when Antigen and Endotoxin are Incorporated within the Same Liposome (1980)

Endotoxin has been shown to enhance the adjuvant effect of liposomes to protein antigens. When a weak antigen and endotoxin were associated with the same liposomes, antibody production could be detected 3 days (72 hours) after injection of the antigen-liposome-endotoxin preparation. When antigen and endotoxin were associated with different liposomes and these antigen-liposome and endotoxin-liposome preparations were injected simultaneously, the adjuvant effect of the liposomes was enhanced also, but not enough to detect antibody production on day 3.
Altitude investigation of 16 flame-holder and fuel-system configurations in tail-pipe burner (1951)

From Introduction: "The data obtained for each configuration are presented in a manner to show the effects of fuel distribution and flame-holder design on net thrust, specific fuel consumption, exhaust-gas temperature, combustion efficiency, operable range of tail-pipe-burner fuel-air ratios, and maximum altitude limit."
A novel automatic tuning scheme for high-frequency high-Q continuous-time filters (2002)

An automatic tuning scheme for high-frequency high-Q continuous time biquadratic filters is proposed. The method is based on tuning the slope of the phase response around the pole frequency. The value of Q is digitally controlled and does not depend on the filter's bandpass gain, which may be quite different than Q in the presence of dominant parasitics. Therefore, very high-frequency high-Q filters can be tuned accurately. Digital phase locked loops and frequency dividers are employed by the tuning circuit.
Neonatal Hyperpigmentation: Diagnosis of Familial Glucocorticoid Deficiency with a Novel Mutation in the Melanocortin‐2 Receptor Gene (2013)

Familial glucocorticoid deficiency (FGD), a rare autosomal recessive disorder of insensitivity to adrenocorticotropic hormone (ACTH), is characterized by isolated glucocorticoid deficiency and preserved mineralocorticoid production. The clinical features include generalized hyperpigmentation, hypoglycemia, failure to thrive, and recurrent infections. Here we describe the case of an infant who exhibited generalized hyperpigmentation and hypoglycemia. A high morning blood ACTH level and low blood cortisol level confirmed the diagnosis of FGD. The patient was found to be homozygous for a novel mutation in the melanocortin-2 receptor gene (635insC, I154H). Early initiation of corticosteroid treatment led to normalization of morning blood ACTH levels and the patient thrived, with subsequent fading of the hyperpigmentation.
Predicting Survival in Heart Failure Case and Control Subjects by Use of Fully Automated Methods for Deriving Nonlinear and Conventional Indices of Heart Rate Dynamics (1997)

These results demonstrate that HRV analysis of ambulatory ECG recordings based on fully automated methods can have prognostic value in a population-based study and that nonlinear HRV indices may contribute prognostic value to complement traditional HRV measures.
The absolute bioavailability of racemic ketamine from a novel sublingual formulation (2013)

Sublingual administration of the ketamine wafer resulted in rapid absorption. The ketamine wafer has comparable bioavailability with other oral transmucosal formulations of ketamine but with markedly reduced inter-subject variability, warranting further evaluation as an analgesic adjunct.
Adiabatic Passage of Light in CMOS-Compatible Silicon Oxide Integrated Rib Waveguides (2011)

A fully complementary metal-oxide-semiconductor-compatible adiabatic passage of light in the visible range is presented in this letter. We experimentally show that a system of three total internal reflection waveguides, which has been defined by using non-stoichiometric silicon oxide, allows a highly efficient transfer of light between the outermost waveguides by adiabatically following one eigenmode of the system. Furthermore, we demonstrate that such transfer of light is very robust against small variations of the system parameters.
Key distribution scheme based on two cryptosystems for hierarchical access control (2006)

To combine the merits of symmetric key cryptosystem and public-key cryptosystem, the authors present a key distribution scheme based on both the Rabin public-key system and the Chinese remainder theorem (CRT) for conditional access system (CAS) in digital TV broadcast, in order to solve dynamic access control problems in user hierarchies. Due to the simplicity of key generation and derivation, the proposed scheme can greatly reduce the encrypting computation and transportation load in the meantime acquire high security. Dynamic access control problems, such as adding/deleting group, adding/deleting relationships and changing secret keys, are easily solved. The proposed scheme is also very suitable for the pay-per-view method
ARFI Ultrasound for <i>In Vivo</i> Hemostasis Assessment Postcardiac Catheterization, Part I: Preclinical Studies (2009)

The world wide prevalence of cardiovascular disease leads to over seven million annual percutaneous coronary catheterization procedures, the majority of which exploit femoral artery access. Femoral puncture sites ('arteriotomies') can be associated with severe vessel complications after sheath removal if hemostasis is not properly achieved. Hemostasis onset is routinely determined by examination for bleeding at the skin puncture; however, clotting along the puncture path can obscure subcutaneous bleeding, and therefore hemostasis is blindly assessed. We hypothesize that hemostasis assessment can be un-blinded by Acoustic Radiation Force Impulse (ARFI) ultrasound. In this first of a two-part series, we present in vivo ARFI hemostasis imaging data obtained in relevant canine models of femoral artery puncture. Above arteriotomies, ARFI-induced displacements were large (3.5 to >5.0 microm) relative to surrounding soft tissue soon after needle removal, which was consistent with our expectation for pooled extravasated blood. ARFI-induced displacements above arteriotomies decreased in magnitude (to approximately 2 microm) some time after needle removal and suggested the onset of hemostasis. This preclinical investigation served as proof of concept and justification for a pilot human study, which is presented in part two of this series.
Evaluation of heart-to-organ ratios of 123I-BMIPP and the dimethyl-substituted 123I-DMIPP fatty acid analogue in humans (1997)

Radioiodinated fatty acid analogues modified by methyl-substitution are used for single photon emission tomography (SPET) imaging of the heart. The effect of mono- and dimethyl-substitution on heart-to-organ ratios was investigated in humans to evaluate their relative merits for SPET image quality. Planar total body scans were performed in fasting patients with coronary artery disease, but without heart failure, 1 h after administration of 111 MBq 15-(p-[I-123]-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP, n = 7) or 111 MBq 15-(p-[I-123]-iodophenyl)-3,3-dimethylpentadecanoic acid (DMIPP, n = 4). Because these branched fatty acids are used for cardiac imaging, we focused on heart-to-organ (heart/organ) ratios by comparing small regions of interest in heart, liver, lung, muscle and bladder. Both tracers showed good visualization of the heart. DMIPP showed a relatively high liver uptake: the heart/liver ratios for DMIPP and BMIPP were 0.39 +/- 0.05 and 1.00 +/- 0.12, respectively (P < 0.0001). Increased lung activity was found for BMIPP, with a heart/lung ratio of 1.63 +/- 0.17 versus 2.32 +/- 0.28 for DMIPP (P < 0.001). In contrast to DMIPP, BMIPP also showed increased activity in the bladder. In conclusion, BMIPP and DMIPP show different distribution patterns. Despite the more favourable heart/lung ratios for DMIPP, the high liver uptake affects cardiac SPET image quality and therefore BMIPP appears to provide superior cardiac SPET image quality in humans.
Transformer & Marchand integrated baluns of extremely small size for 60 GHz applications in 65 nm CMOS technology (2016)

In this paper we present extremely small size integrated balun topologies in 65 nm CMOS technology for millimeter wave applications. An octagon stacked version of the transformer balun and respectively, a stacked version of the Marchand balun are proposed. Both balun structures are designed for 60 GHz applications and present a wideband performance, satisfactory phase and amplitude imbalances. The baluns show maximum phase and amplitude imbalances of 4° and 0.6 dB, respectively. The maximum occupied area is approximately 0.0061 mm2.
Ratiometric photoacoustic imaging of endoplasmic reticulum polarity in injured liver tissues of diabetic mice (2017)

As one of the complications of diabetes, liver injury results in significant hazards. Therefore, accurately diagnosing diabetes-induced liver injury beforehand is crucial for the warning and treatment of hepatic diseases. Diabetes-induced liver injury can cause changes in the microstructure and morphology of liver tissue, leading to changes in the hydrophilic and hydrophobic domains in the endoplasmic reticulum (ER), which is closely associated with changes in cellular ER polarity. So, differences in the ER polarity can indicate the degree of diabetes-induced liver injury. Herein, we develop a new fluorescent and photoacoustic dual-mode probe, ER-P, for detection of the ER polarity of liver tissue in normal and diabetic mice. Upon excitation with a 633 nm laser, ER-P showed increasing fluorescence intensity at 800 nm accompanying a decline in the polarity. Due to its polarity-sensitivity, ER-P was utilized for confocal fluorescence imaging in live cells, and the results demonstrate that ER-P can exclusively accumulate in the ER and indicate an increase in the polarity during ER stress. Importantly, ER-P displayed different absorbance intensities at 700 nm and 800 nm in different polarity environments because of intramolecular charge transfer. The photoacoustic intensity ratios between 700 nm and 800 nm will enable quantification of polarity to be achieved. The ratiometric photoacoustic imaging data demonstrate that the polarity of the liver tissue of diabetic mice is higher than that of the liver tissue of normal mice. Meanwhile, after treatment with the antidiabetic drug metformin, diabetic mice exhibit a reduced polarity environment in their liver tissue. The proposed study may serve as a new approach for the early diagnosis and therapeutic evaluation of diabetes-induced liver injury.