gebhart/patrepeval huggingface dataset:
Positive effect of partial zona pellucida digestion on <i>in vitro</i> fertilization of mouse oocytes with cryopreserved spermatozoa (2009)

Cryopreservation of mouse spermatozoa has been widely used; however, fertility of frozen spermatozoa in some strains, especially when inseminating cryopreserved oocytes, is low and may be improved by assisted fertilization techniques. The present study was performed to investigate the effect of partial zona pellucida (ZP) digestion on the in vitro fertilization (IVF) capacity of frozen mouse spermatozoa. Mouse oocytes were subjected to partial ZP digestion using acidic Tyrode's solution (pH 3.1). Fertilization rates in digestion groups (30 or 45 s) were higher (P < 0.05) than that of zona-intact control (78.3% or 86.3% vs. 52.5%). The recovery rate at 45 s was lower (P < 0.05) than that at 30 s (84.2% vs. 97.3%). Among vitrified oocytes, the fertilization rate in treatment group (digested for 30 s) was higher (P < 0.05) than that of zona-intact group (50.8% vs. 22.1%). After embryo transfer at the two-cell stage, 17.7% and 11.8% of transferred embryos derived from fresh and vitrified digested oocytes developed to term and showed no significant difference as compared with that from zona-intact oocytes (24.1%, P > 0.05). These results indicate that partial ZP digestion improves IVF efficiency of fresh and vitrified oocytes with frozen mouse spermatozoa, which can provide valuable information for in vitro assisted fertilization using cryopreserved gametes in the re-establishment of mouse colonies.
A polarimetric current sensor using an orthogonally polarized dual-frequency fibre laser (1998)

We demonstrate a novel -doped fibre laser operating in orthogonally polarized dual-frequency modes and its application to electric current sensing with frequency read-out. A Faraday rotating mirror and spatial hole burning effects in a gain medium and in a saturable absorber are utilized to control the lasing mode and polarization. The polarization mode beat frequency changes linearly in response to the non-reciprocal circular birefringence induced by an external magnetic field. When the laser was applied to sensing an alternating electric current with a simple phase-locked loop signal processing scheme, the slope coefficient of 8.0 kHz per turn and the noise equivalent current of 460 per turn were obtained. The new current sensor is immune to perturbations in the lead fibres.
Reprogramming Nonribosomal Peptide Synthetases for “Clickable” Amino Acids (2014)

Nonribosomal peptide synthetases (NRPSs) are multifunctional enzymes that produce a wide array of bioactive peptides. Here we show that a single tryptophan-to-serine mutation in phenylalanine-specific NRPS adenylation domains enables the efficient activation of non-natural aromatic amino acids functionalized with azide and alkyne groups. The resulting 10(5)-fold switch in substrate specificity was achieved without appreciable loss of catalytic efficiency. Moreover, the effective communication of the modified A domains with downstream modules in dipeptide synthetases permitted incorporation of O-propargyl-L-tyrosine into diketopiperazines both in vitro and in vivo, even in the presence of competing phenylalanine. Because azides and alkynes readily undergo bioorthogonal click reactions, reprogramming NRPSs to accept non-natural amino acids that contain these groups provides a potentially powerful means of isolating, labeling, and modifying biologically active peptides.
Memorabilia (1965)

Memorabilia Get access E. G. Stanley, E. G. Stanley Search for other works by this author on: Oxford Academic Google Scholar Jean Birrell, Jean Birrell Search for other works by this author on: Oxford Academic Google Scholar V. Sillery, V. Sillery Search for other works by this author on: Oxford Academic Google Scholar W. S. M., W. S. M. Search for other works by this author on: Oxford Academic Google Scholar K. S. R. K. S. R. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 12, Issue 1, 18 January 1965, Pages 2–4, https://doi.org/10.1093/notesj/12.1.2 Published: 18 January 1965
On the (un)reliability of eavesdropping (2008)

We investigate the reliability of current generation eavesdropping tools and show that obtaining 'high fidelity' transcripts is harder than previously assumed. Even in situations highly favourable to the eavesdropper, simple unilateral countermeasures are shown to be sufficient to prevent all tested systems from reliably reconstructing communicated messages. Less than a third of the tested systems report irregularities, and 45% incorrectly interpret covertext chosen by the sending party. Unlike cryptography or steganography, the techniques introduced require no cooperation by the communicating parties and, in some case, can be employed entirely by a third party not involved in the communication at all.
Development of 2-DOF haptic devices working with magnetorheological fluids (2006)

The thesis presents the design and development of a 2-DOF (degree of freedom) magnetorheological (MR) fluid based haptic joystick and studies its applications in virtual reality. MR fluids are controllable fluids that can generate adaptable resistance forces when subjected to a magnetic field. This feature is capable of realizing novel haptic devices. The developed system consists of three main parts: MR joystick, control and display hardware, and software. The MR joystick is constructed of two disc-shaped MR actuators positioned perpendicularly with a gimbal structure, which transfers the movement of the joystick handle into two actuator rotary movements. Therefore, operators can feel the resisting force generated by the two actuators. The dimensions of the actuators have been optimized using finite element analysis, and the steady-state performance of the actuators has been measured and analyzed. The kinetics of the joystick in terms of working space and resistance will be discussed. In the thesis, a subhysteresis model and a torque converting method will be employed to enhance the accuracy of the force control. The applications of the MR joystick in virtual reality will be demonstrated by using six typical interface examples designed in LabVIEW. These demonstrations show that the MR haptic devices have a huge application potential in entertainment, medical, and general industry fields.
Architecture for Faster RAM Controller Design with Inbuilt Memory (2010)

In this era of fast processors and processors with many cores, there is a requirement for faster and bigger memories. But today the speed of fetching data from memories is not able to match up with speed of processors. So there is the need for a fast memory controller. The responsibility of the controller is to match the speeds of the processor on one side and memory on the other so that the communication can take place seamlessly. Here we have built a memory controller which is specifically targeted for DRAM. Certain novel features were included in the design which could increase the overall efficiency of the controller, such as, searching the internal memory of the controller for the requested data for the most recently used data, instead of going to the RAM to fetch it. The design was implemented on Xilinx ISE till the final simulation and synthesis.
Quinolone resistance in campylobacter isolated from man and poultry following the introduction of fluoroquinolones in veterinary medicine (1991)

Eight hundred and eighty-three strains of Campylobacter spp. isolated between 1982 and 1989 from human stools and poultry products were screened for quinolone resistance. In this period the prevalence of resistant strains isolated from poultry products increased from 0% to 14%. During the same period the prevalence in man increased from 0% to 11%. The emergence of quinolone resistance has implications for the identification of campylobacter up to species level: the susceptibility for nalidixic acid can no longer be used as a criterion for identification in the laboratory. The rapid emergence of resistant campylobacter may also have important implications for the treatment and prophylaxis of diarrhoeal disease. The increase of quinolone resistance coincides with the increasing use of fluoroquinolones in human and veterinary medicine. Extensive use of enrofloxacin in poultry and the almost exclusive transmission route of campylobacter from chicken to man, in The Netherlands, suggests that the resistance observed is mainly due to the use of enrofloxacin in the poultry industry.
Templated Synthesis and Electron Microscopy Characterization of Pt Nanoparticles via Carbon Nanotube/DNA Molecules (2007)

Extended abstract of a paper presented at Microscopy and Microanalysis 2007 in Ft. Lauderdale, Florida, USA, August 5 – August 9, 2007
On the Way to Graphane—Pronounced Fluorescence of Polyhydrogenated Graphene (2012)

Chemistry meets graphane: a Birch-type reaction using frozen water as a gentle proton source causes the exfoliation of graphite and formation of hydrogenated graphene with electronically decoupled π-nanodomains. This highly functionalized graphene displays pronounced fluorescence.
Stokes trap for multiplexed particle manipulation and assembly using fluidics (2016)

The ability to confine and manipulate single particles and molecules has revolutionized several fields of science. Hydrodynamic trapping offers an attractive method for particle manipulation in free solution without the need for optical, electric, acoustic, or magnetic fields. Here, we develop and demonstrate the Stokes trap, which is a new method for trapping multiple particles using only fluid flow. We demonstrate simultaneous manipulation of two particles in a simple microfluidic device using model predictive control. We further show that this approach can be used for fluidic-directed assembly of multiple particles in solution. Overall, this technique opens new vistas for fundamental studies of particle-particle interactions and provides a new method for the directed assembly of colloidal particles.
Follicular Cell Implantation: An Emerging Cell Therapy for Hair Loss (2005)

The cells of the adult follicular dermal papilla retain a powerful hair-inductive capacity acquired during embryonic hair morphogenesis. This inductive capacity is the basis of a cell therapy called follicular cell implantation in which dermal papilla cells from a small number of donor follicles are expanded in culture and then implanted into a bald region of scalp. In this manner, many new follicles can be formed from the cells of a few.
Semi-blind maximum-likelihood multichannel estimation with Gaussian prior for the symbols using soft decisions (2002)

We present maximum-likelihood (ML) approaches to semi-blind estimation of multiple FIR channels. The first approach, DML, is based on a deterministic model. The second one, GML is based on a Gaussian model in which the input symbols are considered as Gaussian random variables: this model leads to better and more robust performance than DML. Algorithms are presented to solve DML and GML and the significant improvement of GML w.r.t. DML is demonstrated. A soft decision strategy is also presented to improve ML performance: the most reliable decisions taken at the output of an equalizer built from a semi-blind ML channel estimate are treated as known symbols and semi-blind ML is reiterated with an augmented number of known symbols.
Heterogeneous distribution of the two components of delayed rectifier K+ current: a potential mechanism of the proarrhythmic effects of methanesulfonanilideclass III agents (1999)

The regional differences in IK, in particular differences in its two components may underlie the regional disparity in APD, and that methanesulfonanilide class III antiarrhythmic agents such as E-4031 may cause a greater spatial inhomogeneity of ventricular repolarization, leading to re-entrant arrhythmias.
NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner (2009)

Anaplastic large cell lymphoma (ALCL) is characterized by the presence of the t(2;5)(p23;q35) generating the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) fusion protein, a hyperactive kinase with transforming properties. Among these properties is the ability to regulate activity of the p53 tumor suppressor protein. In many human cancers, p53 is inactivated by mutation or other means, in some cases as a result of up-regulation of the negative regulator MDM2. However, the majority of ALK-expressing ALCL carry wild-type p53 and do not over express MDM2. We demonstrate a novel p53-dependent pathogenetic mechanism in ALK-expressing lymphoma. We confirm previously published reports of NPM-ALK-induced activation of the phosphoinositide (PI) 3-kinase and Jun N-terminal kinase (JNK) stress-activated protein (SAP) kinase proteins, but in this study demonstrate a role for these in the regulation of p53 activity in an intricate signaling system. Specifically, constitutive ALK signaling leads to the functional inactivation and/or degradation of p53 in JNK and MDM2 dependent manners. We also show nuclear exclusion of p53 in a PI 3-kinase-dependent manner. Furthermore, we demonstrate that reactivation of p53 in ALK-expressing cells as a result of pharmacologic inhibition of JNK, PI 3-kinase, and/or MDM2 activities results in the induction of apoptosis suggesting a novel therapeutic modality.
Generalized Blind Mismatch Correction for a Two-Channel Time-Interleaved ADC: Analytic Approach (2007)

Time-interleaved analog-to-digital converters (TIADC) require mismatch calibration to achieve high signal-to-noise ratios. In this paper, we present a new blind technique for M=2 TIADC's with following properties: (1) correction of general mismatches as well as static gain and timing error, (2) unique multi-parameter identification under realistic assumptions, and (3) analytic error measure and gradient. The proposed method overcomes the limitation of traditional gain-timing mismatch model. Time-frequency transformation is eliminated by analytic approach, enhancing efficiency.
Smart microscope: an adaptive optics learning system for aberration correction in multiphoton confocal microscopy (2000)

Off-axis aberrations in a beam-scanning multiphoton confocal microscope are corrected with a deformable mirror. The optimal mirror shape for each pixel is determined by a genetic learning algorithm, in which the second-harmonic or two-photon fluorescence signal from a reference sample is maximized. The speed of the convergence is improved by use of a Zernike polynomial basis for the deformable mirror shape. This adaptive optical correction scheme is implemented in an all-reflective system by use of extremely short (10-fs) optical pulses, and it is shown that the scanning area of an f:1 off-axis parabola can be increased by nine times with this technique.
Familial Adenomatous Polyposis: Prevalence of Adenomas in the Ileal Pouch After Restorative Proctocolectomy (2001)

Adenomas are frequently found in the ileal pouch of patients after restorative proctocolectomy for FAP. Regular endoscopic surveillance of the pouch is recommended at a frequency similar to that of upper gastrointestinal endoscopy.
Modeling a Submicrometer Electrostatic Motor (2003)

Numerical models are developed for a recently proposed submicrometer device that uses the electric field energy of a biased parallel-plate semiconducting capacitor to propel a piston through the open capacitor gap. Through variation of design parameters or applied external bias, actuator forces on the order of hundreds of piconewtons are developed for device size scales ranging from 10(-7) m to 10(-4) m per side. A rotary configuration of the device is also presented.
Basic Study on Traction Control of Electric Vehicle (1998)

Recent researches of electric vehicle are normally focused on batteries and motors themselves. However electric vehicle can achieve high performance motion control by taking advantage of its excellent controllability. In this paper, we propose “traction control”. First, we clarify the static characteristic of vehicle slip phenomena by introducing “constant slip ratio curve”. Next, we propose “model following control” and “slip ratio control” and show their effectiveness by experiments using a real test vehicle.
[Hygienic processing of dental transmission instruments (handpieces and instruments, turbines) in dental practice]. (1995)

The efficacy of a steam disinfection method for the processing of used instruments in dental practice was tested with 274 high-speed turbines and handpieces. The instruments treated with streaming steam were both taken out of the dental practice of treatment and artificially contaminated with five different test-microorganisms (E. coli, P. aeruginosa, S. aureus, E. faecium, C. albicans) and different concentrations of serum (1%, 10%, 20%). In spite of the narrow channels of these instruments a microbial reduction of more than 5 log10 steps could be achieved in all cases. Thus dental high-speed turbines and handpieces can reliably be disinfected with streaming steam.
Cast blasting - state of the art (1999)

Abstract Cast blasting technique reduces the overburden handling cost considerably. Due to this economical advantage, it is gaining importance day by day. This paper addresses the technical analysis of cast blasting technique. Economical criterion of this technique has been dealt with in detail. How this casting can be a viable alternative to shovel/dumper combination or dragline operation, is also discussed. Environmental problems associated with this method are outlined. Case studies regarding successful application of this technique is mentioned.
Ultraviolet B Light Emitting Diodes (LEDs) Are More Efficient and Effective in Producing Vitamin D3 in Human Skin Compared to Natural Sunlight (2017)

Vitamin D, the sunshine vitamin is important for health. Those with fat malabsorption disorders malabsorb vitamin D and thus must rely on cutaneous production of vitamin D<sub>3</sub>. Vitamin D<sub>3</sub> is generated secondary to exposure to ultraviolet B (UVB) radiation (whether from the sun or from an artificial source). Light emitting diodes (LEDs) have been developed to emit ultraviolet radiation. Little is known about the efficiency of UVB emitting LEDs tuned to different wavelengths for producing vitamin D<sub>3</sub> in human skin. Ampoules containing 7-dehydrocholesterol were exposed to a LED that emitted a peak wavelength at 293, 295, 298 or 305 nm to determine their efficiency to produce previtamin D<sub>3</sub>. The 293 nm LED was best suited for evaluating its effectiveness for producing vitamin D in human skin due to the shorter exposure time. This LED was found to be 2.4 times more efficient in producing vitamin D<sub>3</sub> in human skin than the sun in less than 1/60<sup>th</sup> the time. This has significant health implications for medical device development in the future that can be used for providing vitamin D supplementation to patients with fat malabsorption syndromes as well as patients with other metabolic abnormalities including patients with chronic kidney disease.
Comparison of two radiographic techniques for evaluation of hip joint laxity in 10 breeds of dogs (2004)

Distraction radiography detected the greatest range and magnitude of passive hip laxity in the 10 breeds of dogs. The difference in values between breeds known to have high prevalence of canine hip dysplasia and those in Borzois was greater for DI than for HEI. Breeds must be evaluated individually because of inherent differences in hip joint laxity.
자녀 양육비와 둘째 자녀 출산의도 (2010)

This study investigated the association between the expenditures for childrearing and the intention to have the second childbirth applying the recursive equation models. The major results were as follows. First, more than half of the households with one child did not have an intention to have the second childbirth. Second, about 40% of the household expenditure was spent for childrearing. About 36% of the childrearing expenditure was spent on the childcare and education, and about 64% on purchase of goods and services for child. Third, the variables which had a significant effect on the intention to have the second childbirth were child`s age, mother`s education, father`s income, the private educational expenditure, and consumption expenditure for child. The intention to have the second childbirth did not have a significant effect on the level of childrearing expenditure. The implications for the family policies were suggested.
A Compact Dual-Band Pattern Diversity Antenna by Dual-Band Reconfigurable Frequency-Selective Reflectors With a Minimum Number of Switches (2012)

A novel compact dual-band pattern diversity antenna is proposed. Dual-band reconfigurable frequency-selective reflectors are designed and applied to form a right-angle corner reflector antenna with reconfigurable patterns. With only one switch, the reconfigurable frequency-selective reflector can be controlled to be transmissive or reflective to vertically polarized waves at 2.45 and 5.25 GHz. By changing the combinations of the switch states, multiple patterns can be obtained. A dual-band feeding antenna designed via using the coupling effects is made to achieve well-matching conditions in all circumstances corresponding to various switch states at both frequencies. The measured results show good agreement with the calculated ones and demonstrate good pattern diversity virtues.
Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution (2008)

Several mammalian peptide hormones and proteins from plant and animal origin contain an N-terminal pyroglutamic acid (pGlu) residue. Frequently, the moiety is important in exerting biological function in either mediating interaction with receptors or stabilizing against N-terminal degradation. Glutaminyl cyclases (QCs) were isolated from different plants and animals catalyzing pGlu formation. The recent resolution of the 3D structures of Carica papaya and human QCs clearly supports different evolutionary origins of the proteins, which is also reflected by different enzymatic mechanisms. The broad substrate specificity is revealed by the heterogeneity of physiological substrates of plant and animal QCs, including cytokines, matrix proteins and pathogenesis-related proteins. Moreover, recent evidence also suggests human QC as a catalyst of pGlu formation at the N-terminus of amyloid peptides, which contribute to Alzheimer's disease. Obviously, owing to its biophysical properties, the function of pGlu in plant and animal proteins is very similar in terms of stabilizing or mediating protein and peptide structure. It is possible that the requirement for catalysis of pGlu formation under physiological conditions may have triggered separate evolution of QCs in plants and animals.
Lazy symbolic model checking (2000)

In this paper w e presen t a lazy model checking approach aimed at improving the efficiency and capacity of symbolic model checking. The lazy approach dynamically computes an abstraction of a circuit model for each pre-image computation based on the partial result leading to the computation. A t the heart of the approach is a lazy algorithm for transition relation building and pre-image computation. A variable minimization heuristic is then proposed to maximize the benefit of the lazy algorithm in iterative fix-point computations. This approach shows greater promise in complexit y reduction than the cone of influence approach.