gebhart/patrepeval huggingface dataset:
Women Engineers: The Continuing Crusade (2001)

The Careers Review of Engineering Women (CREW) project investigates whether women engineers in Australia are less likely to stay in the profession than male engineers. The review found that women engineers do face many difficulties in their workplace. In spite of this environment many still wish to encourage their female children to study engineering if they show an interest.
Designing with speech acts to elude disfluency in human-computer dialogue systems (2009)

We have conducted a pilot-study of one particular aspect of computer system design, namely how the speech acts in a human--computer dialogue system influence the disfluency production of the user. We have analysed two travel-booking corpora with the aim to find out how many disfluencies the various speech acts in the dialogues of the corpora produce. We found that the speech acts do influence the disfluency rates, and that this trend was especially discernible when addressing the `openness&apos; of the speech acts. Our findings indicate that one way of reducing disfluencies in spoken human--computer systems would be to reduce the number of speech acts which present difficulty in processing for the user, and we propose that this be done in the design of the dialogue manager of the system.
Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex–Induced Arthritis (2013)

Factor H (fH) is an endogenous negative regulator of the alternative pathway (AP) that binds polyanions as well as complement activation fragments C3b and C3d. The AP is both necessary and sufficient to develop collagen Ab-induced arthritis (CAIA) in mice; the mechanisms whereby normal control of the AP is overcome and injury develops are unknown. Although primarily a soluble circulating protein, fH can also bind to tissues in a manner dependent on the carboxyl-terminal domain containing short consensus repeats 19 and 20. We examined the role of fH in CAIA by blocking its binding to tissues through administration of a recombinant negative inhibitor containing short consensus repeats 19 and 20 (rfH19-20), which impairs fH function and amplifies surface AP activation in vitro. Administration of rfH19-20, but not control rfH3-5, significantly worsened clinical disease activity, histopathologic injury, and C3 deposition in the synovium and cartilage in wild-type and fH(+/-) mice. In vitro studies demonstrated that rfH19-20 increased complement activation on cartilage extracts and injured fibroblast-like synoviocytes, two major targets of complement deposition in the joint. We conclude that endogenous fH makes a significant contribution to inhibition of the AP in CAIA through binding to sites of immune complex formation and complement activation.
Ferrohydrodynamic modeling of magnetic nanoparticle harmonic spectra for magnetic particle imaging (2015)

Magnetic Particle Imaging (MPI) is an emerging imaging technique that uses magnetic nanoparticles as tracers. In order to analyze the quality of nanoparticles developed for MPI, a Magnetic Particle Spectrometer (MPS) is often employed. In this paper, we describe results for predictions of the nanoparticle harmonic spectra obtained in a MPS using three models: the first uses the Langevin function, which does not take into account finite magnetic relaxation; the second model uses the magnetization equation by Shliomis (Sh), which takes into account finite magnetic relaxation using a constant characteristic time scale; and the third model uses the magnetization equation derived by Martsenyuk, Raikher, and Shliomis (MRSh), which takes into account the effect of magnetic field magnitude on the magnetic relaxation time. We make comparisons between these models and with experiments in order to illustrate the effects of field-dependent relaxation in the MPS. The models results suggest that finite relaxation results in a significant drop in signal intensity (magnitude of individual harmonics) and in faster spectral decay. Interestingly, when field dependence of the magnetic relaxation time was taken into account, through the MRSh model, the simulations predict a significant improvement in the performance of the nanoparticles, as compared to the performance predicted by the Sh equation. The comparison between the predictions from models and experimental measurements showed excellent qualitative as well as quantitative agreement up to the 19th harmonic using the Sh and MRSh equations, highlighting the potential of ferrohydrodynamic modeling in MPI.
Potential CO<sub>2</sub> Leakage Reduction through Biofilm-Induced Calcium Carbonate Precipitation (2012)

Mitigation strategies for sealing high permeability regions in cap rocks, such as fractures or improperly abandoned wells, are important considerations in the long term security of geologically stored carbon dioxide (CO(2)). Sealing technologies using low-viscosity fluids are advantageous in this context since they potentially reduce the necessary injection pressures and increase the radius of influence around injection wells. Using aqueous solutions and suspensions that can effectively promote microbially induced mineral precipitation is one such technology. Here we describe a strategy to homogenously distribute biofilm-induced calcium carbonate (CaCO(3)) precipitates in a 61 cm long sand-filled column and to seal a hydraulically fractured, 74 cm diameter Boyles Sandstone core. Sporosarcina pasteurii biofilms were established and an injection strategy developed to optimize CaCO(3) precipitation induced via microbial urea hydrolysis. Over the duration of the experiments, permeability decreased between 2 and 4 orders of magnitude in sand column and fractured core experiments, respectively. Additionally, after fracture sealing, the sandstone core withstood three times higher well bore pressure than during the initial fracturing event, which occurred prior to biofilm-induced CaCO(3) mineralization. These studies suggest biofilm-induced CaCO(3) precipitation technologies may potentially seal and strengthen fractures to mitigate CO(2) leakage potential.
PURE mRNA display and cDNA display provide rapid detection of core epitope motif via high‐throughput sequencing (2021)

The reconstructed in vitro translation system known as the PURE system has been used in a variety of cell-free experiments such as the expression of native and de novo proteins as well as various display methods to select for functional polypeptides. We developed a refined PURE-based display method for the preparation of stable messenger RNA (mRNA) and complementary DNA (cDNA)-peptide conjugates and validated its utility for in vitro selection. Our conjugate formation efficiency exceeded 40%, followed by gel purification to allow minimum carry-over of components from the translation system to the downstream assay enabling clean and efficient random peptide sequence screening. We chose the commercially available anti-FLAG M2 antibody as a target molecule for validation. Starting from approximately 1.7 × 10<sup>12</sup> random sequences, a round-by-round high-throughput sequencing showed clear enrichment of the FLAG epitope DYKDDD as well as revealing consensus FLAG epitope motif DYK(D/L/N)(L/Y/D/N/F)D. Enrichment of core FLAG motifs lacking one of the four key residues (DYKxxD) indicates that Tyr (Y) and Lys (K) appear as the two key residues essential for binding. Furthermore, the comparison between mRNA display and cDNA display method resulted in overall similar performance with slightly higher enrichment for mRNA display. We also show that gel purification steps in the refined PURE-based display method improve conjugate formation efficiency and enhance the enrichment rate of FLAG epitope motifs in later rounds of selection especially for mRNA display. Overall, the generalized procedure and consistent performance of two different display methods achieved by the commercially available PURE system will be useful for future studies to explore the sequence and functional space of diverse polypeptides.
Dual-pulse pulse position modulation (DPPM) for deep-space optical communications: Performance and practicality analysis (2012)

Due to its simplicity and robustness against wave-front distortion, pulse position modulation (PPM) with photon counting detector has been seriously considered for long-haul optical wireless systems. This paper evaluates the dual-pulse case and compares it with the conventional single-pulse case. Analytical expressions for symbol error rate and bit error rate are first derived and numerically evaluated, for the strong, negative-exponential turbulent atmosphere. The capacity of the turbulent FSO channel modeled as a Z-channel is evaluated, and throughput, bandwidth efficiency and energy efficiency of Dual-pulse and single-pulse PPM are subsequently assessed. It is shown that, under a set of practical constraints including pulse width and pulse repetition frequency (PRF), dual-pulse PPM enables a better channel utilization and hence a higher throughput than its single-pulse counterpart. This result is new and different from the previous idealistic studies that showed multi-pulse PPM provided no essential information-theoretic gains over single-pulse PPM.
BINDING OF QUATERNARY AMMONIUM SALTS TO ACETYLCHOLINE RECEPTORS: POSSIBLE CHEMICAL WARFARE NERVE AGENTS (2013)

Classical chemical nerve agents are organophosphate based compounds such as Sarin, Soman, Tabun, VX and others. These compounds inhibit acetylcholinesterases in the synapses of nerve junctions. Instead of inactivating acetylcholinesterases, compounds, quaternary amines, can block nerve transmission by binding primarily to the acetylcholine receptor sites. The U.S. Patent Office has published 23 unique patents or invention registrations on the synthesis of compounds that can bind to muscarinic and nicotinic acetylcholine receptors. It is likely that some of these compounds could serve as either polarizing or nonpolarizing nerve agents that bind to the acetylcholine receptor and block binding of acetylcholine. This paper has systematically reviewed a series of bisquaternary amines that could be potentially deadly nerve agents. Analogous tertiary amines, based on the structure of the parent bisquaternary amines, have been proposed as compounds that might be more soluble in membranes making them more bioavailable and toxic. Finally, methods have been discussed that could identify this class of compounds using a bioassay for binding to the acetylcholine receptor. A tool in the identification of these compounds, the Hofmann elimination reaction, has been proposed as a novel method for helping to establish that quaternary or tertiary amines are functional groups of the nerve agent.
Deterioration of Reflecting Coatings by Intermetallic Diffusion (1972)

Gold diffraction gratings overcoated with Al + MgF(2) to increase their efficiency in the vacuum ultraviolet suffered a severe loss in efficiency within six months to a year after coating; for example, from 50% to 2% at lambda1216 A. The cause of this loss was assumed to be interdiffusion of Au and Al; therefore, a more complete study of Au-Al film combinations was performed. The coatings were aged at room and elevated temperatures. Reflectance measurements were made in the visible and vacuum ultraviolet spectral regions. For wavelengths longer than lambda900 A, the measurements show very little change until the diffusion boundary reaches the penetration depth of the radiation. If Al is the first surface layer, however, reflectance measurements at lambda584 A permit measuring the progress of the diffusion boundary toward the Al surface because of the low absorptance of Al at this wavelength. Interdiffusion can be effectively eliminated by the use of thin dielectric layers uch as SiO and the natural oxide of Al. Such protected coatings have been exposed for one week at a temperature of 170 degrees C with no visible sign of diffusion, whereas a similar coating without the barrier layer would become useless in less than 1 h. Some preliminary studies have been made with Pt-Al film combinations.
Glutathione-Associated Regulation of Plant Growth and Stress Responses (2005)

A reduced form of glutathione (GSH) is considered to protect the cell from oxidative damage, based on its redox buffering action and abundance in the cell. However, in plants, the high redox potential molecule ascorbate exists at comparable or higher concentrations and is used for scavenging hydrogen peroxide as an electron donor. Recently, examples that cannot be explained simply by the antioxidant activity of GSH have been increasing in number. This article summarizes the recent findings on the glutathione-associated events in plants, in particular, growth and development including cell differentiation, cell death and senescence, pathogen resistance, and enzymatic regulation.
Heat shock protein 90 targeting therapy: state of the art and future perspective (2015)

Heat shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone that plays a role in stabilizing and activating more than 200 client proteins. It is required for the stability and function of numerous oncogenic signaling proteins that determine the hallmarks of cancer. Since the initial discovery of the first Hsp90 inhibitor in the 1970s, multiple phase II and III clinical trials of several Hsp90 inhibitors have been undertaken. This review provides an overview of the current status on clinical trials of Hsp90 inhibitors and future perspectives on novel anticancer strategies using Hsp90 inhibitors.
Generalized Vibration Analysis by Means of the Mechanical Transients Analyzer (1947)

Abstract This paper presents the results of a general study that has been made of a linear system having 2 deg of freedom. This is representative for many mechanical vibration problems as well as for problems of other physical systems. The system is described specifically in terms of the mechanical parameters of translational motion and consists of one mass, spring, dashpot system mounted on another. Three types of generalized solutions are given for the maximum motion of the first system relative to the second, or the maximum stress developed in the spring of the first system. One of these is for known sinusoidal forces applied to the second system, one is for the whole system striking a fixed base at a known velocity without rebound, and one is for such an impact and one rebound. The solutions were obtained on the mechanical transients analyzer which employs the principle of electric-circuit analogy. The solutions are given in dimensionless curve form for a wide range of all parameters.
Comparison of different theories for focusing through a plane interface (1997)

We consider the problem of light focusing by a high-aperture lens through a plane interface between two media with different refractive indices. We compare two recently published diffraction theories and a new geometrical optics description. The two diffraction approaches exhibit axial distributions with little difference. The description based on geometrical optics is shown to agree well with the diffraction optics results. Also, some implications for three-dimensional imaging are discussed.
Creativity As an Exact Science (1984)

This book discusses the principles of controlling thinking in the solution of inventive problems that are transposed to the organization of creative thinking in any sphere of human activity. It is aimed at the engineer and also comprehensible to people who do not work with technology.
Efficacy of interventions for prevention of chemotherapy‐induced alopecia: A systematic review and meta‐analysis (2014)

Chemotherapy-induced alopecia (CIA) is a highly distressing event for cancer patients, and hence, we here aimed to assess the efficacy of various interventions in the prevention of CIA. We searched PubMed, EMBASE and the Cochrane Library, from June 20, 2013 through August 31, 2013. Two of the authors independently reviewed and selected clinical trials that reported the efficacy of any intervention for prevention of CIA compared with that of controls. Two authors extracted data independently on dichotomized outcome in terms of CIA occurrence. Relative risks (RRs) and 95% confidential intervals (CIs) were calculated for efficacy of CIA prevention by using random-effect or fixed-effect models. Out of 691 articles retrieved, a total of eight randomized controlled trials and nine controlled clinical trials involving 1,098 participants (616 interventions and 482 controls), were included in the final analyses. Scalp cooling, scalp compression, a combination of cooling and compression, topical minoxidil and Panicum miliaceum were used as interventions. The participants were mainly breast cancer patients receiving doxorubicin- or epirubicin-containing chemotherapy. Scalp cooling, which is the most popular preventive method, significantly reduced the risk of CIA (RR = 0.38, 95% CI = 0.32-0.45), whereas topical 2% minoxidil and other interventions did not significantly reduce the risk of CIA. No serious adverse effects associated with scalp cooling were reported. Our results suggest that scalp cooling can prevent CIA in patients receiving chemotherapy. However, the long-term safety of scalp cooling should be confirmed in further studies.
2 GHz repetition-rate femtosecond blue sources by second harmonic generation in a resonantly enhanced cavity (2005)

We report a 2GHz repetition-rate, all-solid-state femtosecond blue source. Pumped by a 740mW femtosecond Ti:sapphire laser with the same repetition rate, 150mW femtosecond pulses at 409nm can be efficiently generated from the external resonant cavity with a lithium triborate crystal.
An iconic language for the graphical representation of medical concepts (2008)

VCM can be learnt in a few hours and appears to be easy to read. It can now be used in a second step: the design of graphical interfaces facilitating access to drug monographs. It could also be used for broader applications, including the design of interfaces for consulting other types of medical document or medical data, or, very simply, to enrich medical texts.
Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME <sup>®</sup> trial (2016)

In patients with type 2 diabetes and high cardiovascular risk, empagliflozin reduced heart failure hospitalization and cardiovascular death, with a consistent benefit in patients with and without baseline heart failure.
Synthesis and Assignment of Absolute Configuration of (−)-Oleocanthal:  A Potent, Naturally Occurring Non-steroidal Anti-inflammatory and Anti-oxidant Agent Derived from Extra Virgin Olive Oils (2005)

[structure: see text] Effective total syntheses and the assignment of absolute configurations of both the (+)- and (-)-enantiomers of oleocanthal 1 (a.k.a. deacetoxy ligstroside aglycon), the latter derived from extra virgin olive oils and known to be responsible for the back of the throat irritant properties of olive oils, have been achieved. The absolute and relative stereochemistry of the naturally occurring enantiomer (-)-1 proved to be 3S,4E. Both syntheses begin with d-(-)-ribose, proceed in 12 steps, and are achieved with an overall yield of 7%. Both enantiomers proved to be non-steroidal anti-inflammatory and anti-oxidant agents.
Test function specification in synthesis (1990)

We present a new synthesis for testability method in which a test function is incorporated into the state diagram of the finite state machine (FSM). The test function is specified as a FSM with the same number of state variables as the given object machine. The state graph of the test machine is so defined that each state is uniquely set and observed by an input sequence no longer than ⌈logkn⌉, where n is the number of states and the integer k is a design parameter. The state transition graph of the test machine is superimposed on the state graph of the object function such that a minimal number of new transitions are added. State assignment, logic minimization and technology mapping are then carried out for the combined graph. By design, the embedded test machine is fully testable. Also, since the test machine can control all memory elements, the circuit is effectively tested by a combinational circuit test generator. Scan register is shown to be a special case in this methodology.
Angle Gathers by Reverse-time Migration (2010)

One of the ways to compute angle gathers for reverse-time migration (RTM) is through time lags. Algorithm for the transformation of time lags to angles has been proposed previously by other authors. However, the proposed workflow requires a dip field and is increasingly inaccurate in areas with conflicting dips and for dips greater than 60-degrees. In this paper we propose methods to overcome the dip limitation and to do the angle transformation without explicitly using the dip field. The angle gathers thus obtained can be used for migration velocity analysis or to improve the image quality through stack. We use a synthetic 2D model to compare results obtained using our proposed methods and the conventional workflow. Finally, we show RTM angle gathers for SEAM model using our methods.
Multispectral polarization active imager in the visible band (2000)

We present the concept of a Multispectral Polarization Active Imager operating in the visible range. The acquisition of three degree of polarization (0% < Dp < 100%) images and three intensity images at different wavelengths (RGB) enables to get information about the spectral signature of targets as well as their polarization properties. A theoretical analysis and an experimental validation of this technique are presented. The device is operating in a monostatic configuration, using a white light source to illuminate the target. The reception system consists of a liquid crystal achromatic polarization rotator followed by a liquid crystal color filter and a CCD camera, all driven by a computer. The three polarization images can be merged in one by using a RGB coding in order to visualize the whole polarization information. Results with different targets will be presented, emphasizing polarization effects about backscattering. In particular the degree of polarization is found to be highly correlated to the reflectance of diffuse materials like paints, papers and other coatings. A first interpretation is given to explain this phenomenon. Application to identification of targets with low sensitivity to irradiance can be envisaged thanks to multispectral polarization signature.
Selection with a Peptide Fusion Inhibitor Corresponding to the First Heptad Repeat of HIV-1 gp41 Identifies Two Genetic Pathways Conferring Cross-Resistance to Peptide Fusion Inhibitors Corresponding to the First and Second Heptad Repeats (HR1 and HR2) of gp41 (2011)

We generated four HIV-1 cultures that are resistant to a peptide fusion inhibitor corresponding to the first heptad repeat of gp41 in order to study mechanisms of resistance and gain insights into envelope glycoprotein-mediated membrane fusion. Two genetic pathways emerged that were defined by acquisition of a specific mutation in either the first or second heptad repeat region of gp41 (HR1 or the HR2, respectively). Each pathway was enriched in mutations that clustered in either HR2 and V3 or in HR1 and residues in or near CD4 contact sites. The gp41 mutations in both pathways not only accounted for resistance to the selecting HR1 peptide but also conferred cross-resistance to HR2 peptide fusion inhibitors and enhanced the stability of the six-helix bundle formed by the self-assembly of HR1 and HR2. The gp120 mutations alone enhanced fusion but did not appear to directly contribute to resistance. The implications of these findings for resistance mechanisms and regulation of envelope-mediated fusion are discussed.