gebhart/patrepeval huggingface dataset:
Intramolecular addition of carbon-centered tinthioimidoyl radicals to carbon-carbon double bonds. Synthesis of .gamma.- and .delta.-thiolactams (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular addition of carbon-centered tinthioimidoyl radicals to carbon-carbon double bonds. Synthesis of .gamma.- and .delta.-thiolactamsMario D. Bachi and Daniella DenenmarkCite this: J. Org. Chem. 1990, 55, 11, 3442–3444Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/jo00298a008https://doi.org/10.1021/jo00298a008research-articleACS PublicationsRequest reuse permissionsArticle Views288Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High binding capacity of cyclophilin B to chondrocyte heparan sulfate proteoglycans and its release from the cell surface by matrix metalloproteinases: Possible role as a proinflammatory mediator in arthritis (2003)

Cyclophilin B is a secreted CSA-binding protein involved in inflammatory events. It can induce chemotaxis in human neutrophils and T lymphocytes. The finding that cyclophilin B is an intrinsic component of cartilage and that it can be released by MMPs suggests that it has a role in the pathogenesis of arthritic diseases, even more so since its signaling receptor is present within the inflamed joint both on T cells and in the rheumatoid synovium.
A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites (2005)

A comprehensive method of quantifying intracellular metabolite concentrations would be a valuable addition to the arsenal of tools for holistic biochemical studies. Here, we describe a step toward the development of such method: a quantitative assay for 90 nitrogen-containing cellular metabolites. The assay involves reverse-phase high-performance liquid chromatography separation followed by electrospray ionization and detection of the resulting ions using triple-quadrupole mass spectrometry in selected reaction monitoring mode. For 79 of the 90 metabolites, the assay is linear with a limit of detection of 10 ng/mL or less. Using this method, 36 metabolites can be reliably detected in extracts of the bacterium Salmonella enterica, with the identity of each metabolite confirmed by the presence, on growing of the bacteria in (13)C-glucose, of a peak corresponding to the isotope-labeled form of the compound. Quantitation in biological samples is performed by mixing unlabeled test cell extract with (13)C-labeled standard extract, and determining the (12)C/(13)C-ratio for each metabolite. Using this approach, the metabolomes of growing (exponential phase) and carbon-starved (stationary phase) bacteria were compared, revealing 16 metabolites that are significantly down-regulated and five metabolites that are significantly up-regulated, in stationary phase.
Reactions concerned in Tertiary Amine N-Oxides. XIV. Cyclization Reactions of Amine N-Oxides with [Fe (dipy)<SUB>3</SUB>] Cl<SUB>2</SUB> Complex Catalyst (1982)

1-Benzylisoquinoline N-oxide reacts with [Fe (dipy)3] Cl2 complex catalyst in dil. H2SO4 (pH 1.5-4.0) under N2 atmosphere at 85-95°C to give a protoberberine type compound. Laudanosine N-oxide (I) gives xylopinine (IV), O-methylcorypalline (VI), and N-methylcorydaldine (VII) in the respective yields of 12.5, 3, and 15%. 3, 4-Dimethoxy-N, N-dimethylphenethylamine N-oxide (III) gives a very small amount of VI under the same conditions.
Ultrafast Raman loss spectroscopy: a new approach to vibrational structure determination (2009)

The rapid data acquisition, natural fluorescence rejection and experimental ease are the advantages of the ultra-fast Raman loss scattering (URLS) which makes it a unique and valuable molecular structure-determining technique. URLS is an analogue of stimulated Raman scattering (SRS) but far more sensitive than SRS. It involves the interaction of two laser sources, viz. a picosecond (ps) pulse and white light, with the sample leading to the generation of loss signal on the higher energy (blue) side with respect to the wavelength of the ps pulse, unlike the gain signal observed on the red side in SRS. These loss signals are at least 1.5 times more intense than the SRS signals. Also, the very prerequisite of the experimental protocol for signal detection to be on the higher energy side by design eliminates the interference from fluorescence, which always appears on the red side. Unlike coherent anti-Stokes Raman scattering, URLS signals are not precluded by non-resonant background under resonance condition and also being a self-phase matched process, it is experimentally easier.
A switching power supply of 99% power factor by the dither rectifier (2002)

The authors present a current waveform improvement method, based on the dither effect normally used in the linearization of nonlinear functions. The proposed circuit utilizes this principle to linearize the dead-zone characteristic which is present in the input of capacitor input rectifiers. The principal characteristics of this method are its simple composition and, more importantly, that it avoids the need for current control. The same switching device realizes the input current waveform improvement and the high frequency inverting output. The experimental circuit achieved over 99% input power factor and current distortion below 9%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Wide-gap re-entrant cavity resonators for 900-1500 MHz (1984)

An approximate model for high Qfactor wide-gap re-entrant cavity resonators is presented which is suitable for evaluating the performance of units capable of operation in the 900 MHz and 1500 MHz bands. The model is used to estimate the unloaded Q-factor and temperature stability. Theory and practice are compared.
Characterization of Mammary Tumors Using Noninvasive Tactile and Hyperspectral Sensors (2014)

The use of both tactile and hyperspectral imaging sensors, which exploit the mechanical and physiological changes in tissues, can significantly increase the performance in automatic identification of tumors with malignant histopathology. Tactile imaging measures the elastic modulus of a tumor, whereas hyperspectral imaging detects important biochemical markers. Spontaneous mammary tumors in canines were used to demonstrate the efficacy of our approach. The tactile sensor achieved a sensitivity of 50% and a specificity of 100% in identifying malignant tumors. The sensitivity and specificity of the hyperspectral sensor were 71% and 76%, respectively. We investigated several machine learning techniques for fusing the tactile and spectral data, which increased the sensitivity and specificity to 86% and 97%, respectively. Our tactile and hyperspectral imaging sensors are noninvasive and harmless (no ionized radiation is used). These imaging sensors may not only eliminate unnecessary surgeries, but will also motivate the development of similar sensors for human clinical use, due to the fact that canine and human tumors have similar physiology and biology.
Motion vector prediction for improving one bit transform based motion estimation (2008)

One bit transforms (1BT) have been proposed for lowering the complexity of motion estimation (ME) in video coding. These transforms generate a one bit representation of each pixel in the video that is used in the motion search. This approach can greatly reduce the silicon area and power required for hardware based video encoding. However 1BT methods under-perform traditional Sum of absolute differences (SAD) based motion estimation, particularly for smaller block sizes. In this paper, it is proposed to improve 1BT based ME by predicting the motion vector for each block based on the vectors from previous blocks and modifying the cost function to favor motion vectors close to the predicted one. This takes advantage of the spatial correlation between motion vectors and produces a more uniform motion field. Simulation results show the proposed method can improve the PSNR of frames reconstructed through motion compensation by up to 1 dB and substantially improve the subjective video quality by reducing blocking artifacts.
Learning Flow Cytometry (2003)

This chapter includes the following topics: Information Sources and Resources The Reader's Guide to Periodical Literature Resources and Courses Exploring the Foundations Alternatives to Flow Cytometry
Photo Realistic Image Completion via Dense Correspondence (2018)

In this paper, we propose an image completion algorithm based on dense correspondence between the input image and an exemplar image retrieved from the Internet. Contrary to traditional methods which register two images according to sparse correspondence, in this paper, we propose a hierarchical PatchMatch method that progressively estimates a dense correspondence, which is able to capture small deformations between images. The estimated dense correspondence has usually large occlusion areas that correspond to the regions to be completed. A nearest neighbor field (NNF) interpolation algorithm interpolates a smooth and accurate NNF over the occluded region. Given the calculated NNF, the correct image content from the exemplar image is transferred to the input image. Finally, as there could be a color difference between the completed content and the input image, a color correction algorithm is applied to remove the visual artifacts. Numerical results show that our proposed image completion method can achieve photo realistic image completion results.
Insulin receptor substrate 2: a bridge between Hippo and AKT pathways (2018)

NAFLD induces the development of advanced liver diseases such as NASH and liver cancer. Therefore, understanding the mechanism of NAFLD development is critical for its prevention and treatment. Ablation of PTEN or Hippo pathway components induces liver cancer in a murine model by hyperactive AKT or YAP/TAZ, respectively. Although the regulation of these two pathways occurs in the same hepatocyte, the details of crosstalk between Hippo-YAP/TAZ and PTEN-AKT pathways in liver homeostasis and tumorigenesis still remain unclear. Here, we found that depletion of both PTEN and SAV1 in liver promotes spontaneous NAFLD and liver cancer through hyperactive AKT via YAP/TAZmediated up-regulation of IRS2 transcription. Conversely, NAFLD is rescued by both ablation of YAP/TAZ and activation of the Hippo pathway. Furthermore, human HCC patients with NAFLD showed strong correlation between YAP/TAZ and IRS2 or phospho-AKT expression. Finally, the inhibition of AKT by MK-2206 treatment attenuates NAFLD development and tumorigenesis. Our findings indicate that Hippo pathway interacts with AKT signaling during the intervention with IRS2 to prevent NAFLD and liver cancer. [BMB Reports 2018; 51(5): 209-210].
Neural Induction with Neurogenin1 Increases the Therapeutic Effects of Mesenchymal Stem Cells in the Ischemic Brain (2008)

Mesenchymal stem cells (MSCs) have been shown to ameliorate a variety of neurological dysfunctions. This effect is believed to be mediated by their paracrine functions, since these cells rarely differentiate into neuronal cells. It is of clinical interest whether neural induction of MSCs is beneficial for the replacement therapy of neurological diseases. Here we report that expression of Neurogenin1 (Ngn1), a proneural gene that directs neuronal differentiation of progenitor cells during development, is sufficient to convert the mesodermal cell fate of MSCs into a neuronal one. Ngn1-expressing MSCs expressed neuron-specific proteins, including NeuroD and voltage-gated Ca2+ and Na+ channels that were absent in parental MSCs. Most importantly, transplantation of Ngn1-expressing MSCs in the animal stroke model dramatically improved motor functions compared with the parental MSCs. MSCs with Ngn1 populated the ischemic brain, where they expressed mature neuronal markers, including microtubule associated protein 2, neurofilament 200, and vesicular glutamate transporter 2, and functionally connected to host neurons. MSCs with and without Ngn1 were indistinguishable in reducing the numbers of Iba1+, ED1+ inflammatory cells, and terminal deoxynucleotidyl transferase dUTP nick-end labeling(+) apoptotic cells and in increasing the numbers of proliferating Ki67+ cells. The data indicate that in addition to the intrinsic paracrine functions of MSCs, motor dysfunctions were remarkably improved by MSCs able to transdifferentiate into neuronal cells. Thus, neural induction of MSCs is advantageous for the treatment of neurological dysfunctions.
Repeated vs single physical maneuver in benign paroxysmal positional vertigo (2004)

A single session of repeated physical procedure seems to be clinically superior to one single maneuver and well tolerated. Additional post-treatment measurements are inconvenient and should be abandoned.
Energy-Efficient Distributed Adaptive Multisensor Scheduling for Target Tracking in Wireless Sensor Networks (2008)

Due to uncertainties in target motion and limited sensing regions of sensors, single-sensor-based collaborative target tracking in wireless sensor networks (WSNs), as addressed in many previous approaches, suffers from low tracking accuracy and lack of reliability when a target cannot be detected by a scheduled sensor. Generally, actuating multiple sensors can achieve better tracking performance but with high energy consumption. Tracking accuracy, reliability, and energy consumed are affected by the sampling interval between two successive time steps. In this paper, an adaptive energy-efficient multisensor scheduling scheme is proposed for collaborative target tracking in WSNs. It calculates the optimal sampling interval to satisfy a specification on predicted tracking accuracy, selects the cluster of tasking sensors according to their joint detection probability, and designates one of the tasking sensors as the cluster head for estimation update and sensor scheduling according to a cluster head energy measure (CHEM) function. Simulation results show that, compared with existing single-sensor scheduling and multisensor scheduling with a uniform sampling interval, the proposed adaptive multisensor scheduling scheme can achieve superior energy efficiency and tracking reliability while satisfying the tracking accuracy requirement. It is also robust to the uncertainty of the process noise.
Antigenic relationships between human and cobra complement factors C3 and cobra venom factor (CVF) from the Indian cobra (<i>Naja naja</i>). (1983)

The presence of a factor immunologically related to cobra venom factor (CVF) was demonstrated in serum and plasma from the Indian cobra (Naja naja kaoutia). The factor was purified from cobra plasma by affinity chromatography on an anti-CVF gel and was found to consist of a protein composed of two polypeptide chains similar in size to those of human C3. With use of immunoblotting technique, common antigenic determinants were found in the smaller chain of the prepared material and the beta-chain of human C3; the larger chain may display antigenic determinants present in the alpha-chain of human C3. These findings suggest that this molecule represents the C3 of the cobra complement system. Common antigenic determinants were also demonstrated in the alpha-chain of CVF and the beta-chains of human and cobra C3. No reactions were observed between the beta- and gamma-chains of CVF and any antiserum against human C3 or its subunits. Upon immunodiffusion analysis, cobra serum was found to contain a factor besides C3 sharing antigens specific for CVF, while cobra C3 was antigenically deficient compared to CVF. This suggests that cobra C3 physiologically is degraded to a molecule very similar to or identical with CVF.
Fiber-optic angular sensor with interleaved channel spectra (1986)

The angular position of a polarizer determines the power ratio of two light beams with interleaved channel spectra, filtered from a broadband light-emitting diode. The beams are transmitted simultaneously through a 750-m-long multimode fiber and then analyzed. An angular resolution of 0.5 degrees over a 70 degrees range is obtained, independently of the attenuation of the fiber link.
Processing In A GPS Receiver To Reduce Multipath Errors (1994)

Four techniques of ancillary real-time digital processing of signals in Global Positioning System, GPS, receiver introduced reducing effects of multipath propagation of signals on position estimates produced by receiver. Multipath range errors halved. Applied in addition to other signal-processing techniques and to other techniques designing as receiving antenna to make it insensitive to reflections of GPS signals from nearby objects.
A novel methodology for antenna design and optimization: Variable Zo (2011)

This paper describes "Variable Zo," a novel and proprietary approach to antenna design and optimization. The new methodology is illustrated by applying it to the design of a resistively-loaded bowtie antenna and to two broadband Yagi-Uda arrays. Variable Zo is applicable to any antenna design or optimization methodology. Using it will result in generally better antenna designs across any user-specified set of performance objectives.
Normalization in Econometrics (2007)

The issue of normalization arises whenever two different values for a vector of unknown parameters imply the identical economic model. A normalization implies not just a rule for selecting which among equivalent points to call the maximum likelihood estimate (MLE), but also governs the topography of the set of points that go into a small-sample confidence interval associated with that MLE. A poor normalization can lead to multimodal distributions, disjoint confidence intervals, and very misleading characterizations of the true statistical uncertainty. This paper introduces an identification principle as a framework upon which a normalization should be imposed, according to which the boundaries of the allowable parameter space should correspond to loci along which the model is locally unidentified. We illustrate these issues with examples taken from mixture models, structural vector autoregressions, and cointegration models.
Preparation and cellular uptake of PLGA particles loaded with lamivudine (2012)

Poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with lamivudine and coated with bovine serum albumin (BSA) were prepared via a double emulsion method. The influences of experiments parameters such as volume of inner aqueous phase, concentration of organic phase and ultrasonication time on the particle size and drug entrapment efficiency were investigated, obtaining PLGA particles with a diameter of ∼260 nm and drug entrapment efficiency of ∼35%. The particles were observed by scanning electron microscopy and transmittance electron microscopy, showing a core-shell structure. BCA assay found that 58 mg BSA was present on/in 1 g LPB particles. The loaded lamivudine showed a burst release at beginning and sustained release until 24 h in physiological conditions. Low pH could accelerate the release of lamivudine from PLGA particles, making the PLGA particles potential intelligent intracellular drug carriers. The PLGA particles were readily internalized into the human liver cells within a short time and increased gradually with the prolongation of incubation time regardless of the loading of lamivudine. The particles either resided within lysosomes or transferred to cytoplasm, but could not enter into the cell nucleus. The cell viability was not significantly influenced in the presence of the particles regardless of lamivudine encapsulation, suggesting that this kind of particles may be a good candidate for the intracellular anti-hepatitis B drug delivery.
Flat multi-scalable coding for failure-free video transmission (2003)

The conventional full-redundant duplicate transmission scheme, which is often adopted in video transmission that requires high reliability such as contribution and primary distribution, has a drawback in that the efficiency of utilization of transmission links is low. In order to improve this, it would be effective to realize "flat multi-scalable video transmission", in which the picture can be reconstructed by using any single channel, while combining more than one channel leads to the reconstruction of the picture with even higher quality. In this paper, for this purpose, the authors propose a "complementary sampling method". In this method, the improvement in picture quality is achieved by cancelling out the coding noise which is included in more than one channel. Moreover, it is shown that in this scheme, the objective assessment of picture quality can be performed based only on the received pictures. The authors hope that this study will help to construct a visual communication system with high efficiency and high reliability.
Annual Survey of English Law, 1938. London: Published for the London School of Economics and Political Science by Sweet & Maxwell, Ltd.1939. xxxvi and 434 pp. (10<i>s</i>. 6<i>d</i>.) (1941)

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Heterocyclic Carbenes (2006)

New carbenes open up new vistas. The P-heterocyclic carbene 1 was obtained after planarization of the P atoms in the heterocycle with sterically demanding substituents. The cyclohexyl substituent in the cyclic alkylaminocarbene 2 can be locked by proper substitution in the most sterically demanding conformation such that a low-coordinate metal center, as in complex 3, is stabilized.
Mechanical Relaxations and Transitions in Poly(Vinylidene Fluoride) PVDF (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.