gebhart/patrepeval huggingface dataset:
Potential drugs for the treatment of AIDS (1989)

From our investigations the following compounds have emerged as particularly potent and selective inhibitors of HIV replication: sulphated polysaccharides (i.e. heparin, dextran sulphate, pentosan polysulphate), dideoxynucleoside analogues such as the 3'-azido-and 3'-fluoro-substituted 2',3'-dideoxyribosides of both purines (i.e. guanine, 2,6-diaminopurine) and pyrimidines (i.e. uracil, thymine), and the 9-(2-phosphonylmethoxyethyl) derivatives of adenine, 2-monoaminopurine and 2,6-diaminopurine. All these compounds yield great promise for the treatment of retrovirus infections in humans. Whereas the sulphated polysaccharides interfere with the virus adsorption process, the nucleoside analogues (following intracellular phosphorylation to their 5'-triphosphate) appear to be targeted at the reverse transcriptase.
Rapid ultrafine-tunable optical delay line at the 155-µm wavelength (1998)

A fast, ultrafine-tunable delay line at 1550 nm is demonstrated by use of acousto-optic pulse shaping. Delays of up to 30 ps can be achieved without any optical readjustment. The delay is linear to the rf center frequency applied to the acousto-optic modulator and is fully electronic. It takes only 3micros to switch between different time slots, irrespective of the time separation in the tuning range of 30 ps; for a smaller tuning range the tuning speed can be faster. The tuning resolution and range depend on the choice of system parameters. The pulse energy can be regulated by rf power.
Handbook of Research on Biomedical Engineering Education and Advanced Bioengineering Learning (2012)

"This book explores how healthcare practices have been steered toward emerging frontiers, including, among others, functional medical imaging, regenerative medicine, nanobiomedicine, enzyme engineering, and artificial sensory substitution" - Provided by publisher
Hierarchical Execution: A Technique for Utilizing Multi-Cores to Improve Single-Thread Performance (2010)

In this paper, a new architecture is proposed that obtainshigh performance for single-threaded applications in amulti-core environment, while using simpler cores tomeet the high throughput and low power requirements.
Influence of 2′-Fluoro versus 2′-<i>O</i>-Methyl Substituent on the Sugar Puckering of 4′-<i>C</i>-Aminomethyluridine (2013)

Herein, we report the synthesis of 4'-C-aminomethyl-2'-deoxy-2'-fluorouridine, a therapeutically appealing RNA modification. Conformational analysis by DFT calculations and molecular dynamics simulations using trinucleotide model systems revealed that modified sugar adopts C3'-endo conformation. In this conformer, a weak intramolecular C-H···F H-bond between the hydrogen atom of the 4'-C-CH2 group and the F atom at the 2' position is observed. Comparative studies with unmodified, 2'-fluoro-, 2'-O-methyl-, and 4'-C-aminomethyl-2'-O-methyluridine showed the chemical nature of 2'-substituent dictates the sugar puckering of 2',4'-modified nucleotides.
Ventilator-Induced Lung Injury (2013)

Mechanical ventilation may cause injury to the ventilated lung. This article reviews the probable causes of such injury and ways to prevent it.
The Effect of Hydrogen Addition on the Fluorine Doping Level of SiOF Films Prepared by Remote Plasma-Enhanced Chemical Vapor Deposition Using SiF<sub>4</sub>-Based Plasmas (1998)

Fluorinated silicon dioxide films (SiOF) have been prepared by high-density remote plasma-enhanced chemical vapor deposition from silicon tetrafluoride (SiF 4 ), oxygen and helium feedstock gas mixture at substrate temperature as low as 175°C. Addition of hydrogen has been found to control the fluorine doping level of the SiOF films over a wide range of fluorine concentrations while the SiF 4 -to-O 2 flow rate ratio is kept constant. It has been confirmed that hydrogen addition does not lead to the incorporation of hydrogen in detectable quantities into the grown film with Si–F x bond concentrations in the range of 0.5–4.9 at.% because of effective mutual scavenging behavior of fluorine and hydrogen in the entire range of hydrogen flow rates used. The decrease in the refractive index of the SiOF films from 1.463 to 1.410 and the increase in Si–O–Si bonding angles from about 137° to about 148° were found to be approximately linear with the increase in fluorine concentration. The hydrogen added to the process gas mixture has been found to play an active role in the film formation process affecting both the surface reactions and properties of the obtained SiOF films.
Hybrid frequency-time domain proportional fair resource allocation scheme for LTE downlink (2012)

In this research work, we explored the radio resource allocation schemes used in LTE downlink. We studied the frame and physical resource block (PRB) of LTE both in frequency and time domains. We propose a hybrid proportional fairness scheme (SAMM) which uses proportional fairness (PF) and maximum throughput (MT) schemes in such a way that PF runs for K users in 1st transmission time interval (TTI) and the MT allocates RBs to K-1 users in 2nd TTI. We discard one user who has highest throughput in 1st TTI. Finally we compared round robin, maximum throughput, max-min, proportional fairness, and the proposed scheme using Matlab. Simulation results show that the proposed scheme outperforms the PF for the users with high signal-to-noise ratio and renders 20% increase in sum-throughput at the expense of 19.5% fairness index compared to the PF.
Continuous system and user documentation integration (2014)

Formal user and system documentation is often completely ignored by development teams. This is a direct result of the pain standard documentation tools and processes cause to technical teams. Traditional documentation models hamper the velocity of development. User and/or system documentation is often created and maintained using clunky binary files (i.e. *.docx). Generally, collaboration systems include passing updated versions through long email chains, or network file shares. Additionally, proprietary formats tend to suffer from inconsistencies across operating systems, which can lead to data corruption across teams with disparate work environments. Storing binary files in version control systems is a solution to some of these problems, but versioning binary files is still challenging. Automating and integrating this into a software development life cycle is problematic at best, often resulting in documents languishing behind the pace of a project, or being deprecated entirely. In our organization, we developed a new process to rapidly produce PDFs, HTML, and Word-based documentation from multiple authors and integrated it with our existing automated build system. The process is tool/environment independent and takes full advantage of a version control system. This has increased our efficiency, communication and collaboration in an oft-overlooked area in the software development process.
Performance Evaluation of the GPS Block IIR Time Keeping System (1996)

The Time Keeping System (TKS) is asenhhl to the GPS Block IIR totcrl navigation palload and must provide an crccura!e tinu tmse for each GPS space vehicle. Pcrfonnance ~ 4 1 y s i s of the TKS has been reported previously for the m e in which a rubidium [Rb) atomic frequency standard is used as a reference. In this paper the system error model of the TKS is developed and the perjonnance of the TKS output using either a cesium (Cs) or a rubidium (Rb) atomic frequency shuhrds as a reference is evaluated. The contributions to the TKS output AUM deviation was examined from mch of the three noise sources: olomicfnquency standard (either Cs or Rb), vokge control crystal oscillator (VCXO), and phase mier (PM). In addition, since the TKS does not have a baseplate temperature controller and thr VCXO of the TKS is tempmature-sensitive, a TKS m o r is induced when the VCXO is xubjcd to the orbital tempemlure v- or the space vehicle umbra during solar eclipse. These two temperature-induced TKS output mars are also rxcuninod. Sensitivities of the Allan v a ~ n c e at the TKS output for each of its indrpcndmt input noises are provided and they are valuable for design trade-off and troub*shdng. The resuUs of this paper compare favombly with those obtained by the TKS system Wing. &apos;RK paper will show that when the TKS components m &amp; or meed their sped&amp;- the RlFS TKS and the CAPS TKS should meet their specifications. I 1
Tumour-infiltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic (2004)

The results support the hypothesis that MSI-H colorectal cancers may be more immunogenic than MSS tumours.
Chronic fatigue in patients with unexplained self-reported food hypersensitivity and irritable bowel syndrome: validation of a Norwegian translation of the Fatigue Impact Scale (2013)

The Norwegian translation of the FIS performed excellently in patients with unexplained self-reported food hypersensitivity and IBS, with patients reporting significantly more impact of chronic fatigue than healthy controls.
Computer Vision – A Versatile Technology in Automation of Agricultural Machinery (2010)

The agricultural market in developed countries is evolving from being mechanised in the 20th century, with still larger machines being automated in the 21st century. Development of automation technology for agricultural machinery includes many aspects. As the degree of automation increases, the complexity of automation would rise. The paper focuses on the sensor sub-system, and more specifically, computer vision technology. The emergence of widely available vision technologies has enabled the manufacturers to automate a wide range of tasks. Weed control and auto-guidance systems are two areas in agriculture that have driven the development of vision technology. Applying computer vision technology makes it possible to automate the navigation tasks when the vehicle is driven along crops and other field structures. The operator stress level can be generally reduced and high precision steering in sensitive crops can be maintained through out the day. The driver can concentrate on optimizing the machine settings and ensure a safe operation of the system. Machine settings can be optimised yielding a higher quality in the field operations. The working speed can be increased, thus saving time and money.
6‐ und 8π‐Ringschlußreaktionen von 2‐Oxaheptatrienyl‐Dipolen: Synthese von 3‐Vinyl‐2,3‐dihydrofuranen und 2,3(6,7)‐Dihydrooxepinen (1981)

Abstract Es werden thermisch induzierte Ringerweiterungsreaktionen von Butadienyloxiranen beschrieben. Während die 3(E)‐konfigurierten Epoxytriene 11 ganz überwiegend zu cis ‐3‐Vinyl‐2,3‐dihydrofuranen 15 reagieren und nur die Derivate a, c, h auch geringe Anteile der trans ‐Isomeren 16 bilden, entsteht beim Erhitzen der 3(Z)‐Butadienyloxirane 12 stets ein Dreikomponentengemisch, welches neben den Fünfringprodukten 15/16 noch zusätzlich die Dihydrooxepine 17 (bzw. 29 ) enthält. Als Mechanismus der Ringerweiterungsreaktionen wird eine mehrstufige Sequenz über 2‐Oxaheptatrienyl‐Dipole diskutiert, welche unter Beteiligung von sechs Elektronen zu Dihydrofuranen oder von acht Elektronen zu Dihydrooxepinen elektrocyclisieren. Im Zusammenhang mit 1,7‐Cyclisierungsreaktionen von anderen erweiterten Dipol‐Systemen wird auf die entscheidende Bedeutung der Stereochemie in den Ausgangsprodukten hingewiesen.
Molecular analysis of the polymorphisms of thymidylate synthase on cell‐free circulating DNA in blood of patients with advanced colorectal carcinoma (2009)

As a key enzyme in folate metabolism, the thymidylate synthase (TS) is important for the synthesis of nucleotides. Its polymorphisms may affect the TS gene expression and the susceptibility for Fluoropyrimidine (FU)-based chemotherapies. In this study, we assessed the relationship between the TS genotypes and clinical outcome to 5-FU-based chemotherapy, and examined whether cell-free circulating DNA is applicable for these molecular analyses. We combined the variable number tandem repeat (VNTR) and single nucleotide (SNP) polymorphisms of the TS promoter and the deletion variants (1494del6) in the 3'UTR with the occurrence of loss of heterozygosity (LOH) at the microsatellite markers D18S59, D18S1140, and D18S976 mapped up- and downstream to the TS locus. Cell-free blood DNA, tumor tissues, and leukocytes of 51 patients with advanced colorectal cancer were used. Genotyping revealed linkage disequilibrium between TS promoter and 3'UTR (p = 0.03) in blood and leukocytes. Inverse associations of the response to therapy with the number of polymorphisms (p = 0.05) and the 494del6 polymorphism (p < 0.02) were detected on serum DNA. The quantification of serum DNA showed significant correlations with the 1494del6 variant (p = 0.006) in tumor tissues and the combined polymorphisms in leukocytes (p < 0.04). In contrast to the low LOH frequency in blood, LOH spanned more than one marker in the primary tumor of the majority of the patients suggesting the loss of the entire TS locus. Our data provide insight into the molecular diversity of the regulation of the TS gene expression. This is the first study that compares multi-variant TS genotypes in different clinical specimens.
Measurement of Temperature in General-Purpose Squirre-Cage Induction Motors (1939)

THERE are three fundamental methods of temperature determination1 which might be applied to squirrel-cage motors, namely: 1. The thermometer method 2. The resistance method 3. The embedded-detector method
Impedance Characterization of a Model Au∕Yttria-Stabilized Zirconia∕Au Electrochemical Cell in Varying Oxygen and NO[sub x] Concentrations (2007)

An electrochemical cell serves as a model system to investigate the effect of and . Possible mechanisms responsible for the response are presented. Two dense Au electrodes are co-located on the same side of a dense YSZ electrolyte and are separated from the electrolyte by a porous YSZ layer, present only under the electrodes. While not completely understood, the porous layer appears to result in enhanced response. Impedance data were obtained over a range of frequencies , temperatures , and oxygen (2–18.9%) and concentrations. Spectra were fit with an equivalent circuit, and values of the circuit elements were evaluated. In the absence of , the effect of on the low-frequency arc resistance could be described by a power law, and the temperature dependence by a single apparent activation energy at all concentrations. When both and were present, however, the power-law exponent varied as a function of both temperature and concentration, and the apparent activation energy also showed dual dependence. Adsorption mechanisms are discussed as possibilities for the rate-limiting steps. Implications for impedancemetric sensing are also discussed.
Modeling human supervisory control in heterogeneous unmanned vehicle systems (2009)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2009.
One Hundred Years of Sulfenic Acid Chemistry I. Sulfenyl Halide Syntheses (1970)

The currently known methods for the synthesis of sulfenyl halides, especially sulfenyl chlorides, are discussed. In addition to sulfenyl halides in the narrower sense, in which the halosulfenyl residue is linked to a carbon atom, consideration is also given to compounds in which the linkage with the halosulfenyl residue is via nitrogen, phosphorus, or an acyl group.
Complications Associated with Fracture of the Neck of the Femur in Children (1992)

We reviewed 16 children with 16 displaced fractures of the femoral neck associated with complications. One was a transepiphyseal fracture, 12 were transcervical fractures, and three were basocervical fractures. The mean age at time of fracture was 11 years 7 months (range, 4 years 6 months to 16 years), and the mean length of follow-up after fracture was 6 years 11 months (range, 2-24 years). Complications in this series were avascular necrosis (AVN) (14 patients), nonunion (seven patients), premature physeal closure (15 patients), chondrolysis (seven patients), and coxa vara (two patients). Avascular necrosis, nonunion, and chondrolysis were associated with a poor outcome. Coxa vara or premature physeal closure alone was not responsible for a poor result.
GreenTube (2012)

Mobile video streaming has become one of the most popular applications in the trend of smartphone booming and the prevalence of 3G/4G networks, i.e., HSPA, HSPA+, and LTE. However, the prohibitively high power consumption by 3G/4G radios in smartphones reduces battery life significantly and thus severely hurts user experience. To tackle this challenge, we designed GreenTube, a system that optimizes power consumption for mobile video streaming by judiciously scheduling downloading activities to minimize unnecessary active periods of 3G/4G radio. GreenTube achieves this by dynamically managing the downloading cache based on user viewing history and network condition. We implemented GreenTube on Android-based smartphones. Experimental results show that GreenTube achieves large power reductions of more than 70% (on the 3G/4G radio) and 40% (for the whole system). We believe GreenTube is a desirable upgrade to the Android system, especially in the light of increasing LTE popularity.
Mating disruption or mass trapping? Numerical simulation analysis of a control strategy for lepidopteran pests (2006)

Abstract I have constructed a simulation model applicable to both mass trapping and mating disruption for lepidopteran insect pests. The basic structure of the model is based on mass trapping model proposed by Knipling and McGuire (Agric Info Bull 308:1–20 ), but this was modified to include mechanistic competition among females and lures. Several new implications are derived from the model. (1) Long‐living pests are hard to control. (2) Protandry does not improve control efficiency for pests with low survival rates. (3) Sexual communication across large distances is more difficult to control than that across a short range. (4) There is an upper limit to improvement which can be achieved by increasing the number of pheromone traps. (5) Improving the catching efficiency of traps does not improve mating suppression although improvement of lure efficiency does substantially. The last implication, in particular, has practical importance. If an efficient lure attracts males or inhibits their ability to locate females and mate, mating disruption works as well as mass trapping with the same number of lures. In such circumstances mating disruption should be preferred to mass trapping because the former does not incur the cost of the trapping devices. Mass trapping should, however, be considered in preference to mating disruption if the lure is not efficient enough and no other methods are available.
Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity. (1998)

Thiopurine methyltransferase (TPMT) catalyzes S-methylation of thiopurine drugs such as 6-mercaptopurine. Large variations in levels of TPMT activity in human tissue can result from a common genetic polymorphism with a series of alleles for low activity. This polymorphism is an important factor responsible for large individual variations in thiopurine toxicity and therapeutic efficacy. We now report a new variant allele, TPMT*4, that contains a G--> A transition that disrupts the intron/exon acceptor splice junction at the final 3' nucleotide of intron 9, the terminal intron of the TPMT gene. This new allele cosegregated within an extended kindred with reduced TPMT activity. We attempted to determine the mechanism(s) by which the presence of TPMT*4 might result in low enzyme activity. Although very few mature transcripts derived from allele TPMT*4 were detected, the mutation did lead to generation of at least two aberrant mRNA species. The first resulted from use of a novel splice site located one nucleotide 3' downstream from the original splice junction. That mRNA species contained a single nucleotide deletion and a frameshift within exon 10, the terminal exon of the gene. The second novel mRNA species resulted from activation of a cryptic splice site located within intron 9, leading to inclusion of 330 nucleotides of intron sequence. That sequence contained a premature translation termination codon. TPMT*4 is the first reported allele for low TPMT activity as a result of a mutation within an intron. These observations also provide insight into mechanisms of mRNA processing after disruption of a terminal exon splice junction.
Initial Treatment of Pigmentary Glaucoma (1993)

Ritch, Robert M.D., Editor; Campbell, David G. M.D.; Camras, Carl M.D. Author Information
Forecasting dynamic public transport Origin-Destination matrices with long-Short term Memory recurrent neural networks (2016)

A considerable number of studies have been undertaken on using smart card data to analyse urban mobility. Most of these studies aim to identify recurrent passenger habits, reveal mobility patterns, reconstruct and predict passenger flows, etc. Forecasting mobility demand is a central problem for public transport authorities and operators alike. It is the first step to efficient allocation and optimisation of available resources. This paper explores an innovative approach to forecasting dynamic Origin-Destination (OD) matrices in a subway network using long Short-term Memory (LSTM) recurrent neural networks. A comparison with traditional approaches, such as calendar methodology or Vector Autoregression is conducted on a real smart card dataset issued from the public transport network of Rennes Métropole, France. The obtained results show that reliable short-term prediction (over a 15 minutes time horizon) of OD pairs can be achieved with the proposed approach. We also experiment with the effect of taking into account additional data about OD matrices of nearby transport systems (buses in this case) on the prediction accuracy.
Pid Parameter Optimization Of An Uav Longitudinal Flight Control System (2008)

In this paper, an automatic control system design based on Integral Squared Error (ISE) parameter optimization technique has been implemented on longitudinal flight dynamics of an UAV. It has been aimed to minimize the error function between the reference signal and the output of the plant. In the following parts, objective function has been defined with respect to error dynamics. An unconstrained optimization problem has been solved analytically by using necessary and sufficient conditions of optimality, optimum PID parameters have been obtained and implemented in control system dynamics.
REVIEWS Le Message Humain de Georges Duhamel. Esquisse littéraire. By FALLSWILLIAM F.. Paris: Boivin (Éditions Contemporaines). [1948]. 103 pp. (1949)

Journal Article REVIEWS Get access Le Message Humain de Georges Duhamel. Esquisse littéraire. By WILLIAM F. FALLS. Paris: Boivin (Éditions Contemporaines). [ 1948]. 103 pp. J. HEYWOOD THOMAS J. HEYWOOD THOMAS CARDIFF Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume III, Issue 3, July 1949, Pages 284–285, https://doi.org/10.1093/fs/III.3.284 Published: 01 July 1949
Anatomy of a Data Stream Management System. (2006)

In this paper, we identify issues and present solutions developed – both theoretical and experimental – during the course of developing a data stream management system (DSMS) for applications in a sensor environment. Specifically, we summarize our solutions for CQ processing, trigger mechanisms, and Quality of Service (QoS) management in a stream data processing system. Specifically, we first present our query processing model and then discuss our scheduling strategies to support different requirements of stream applications. We further discuss our QoS framework in such a DSMS and present our load shedding techniques, queueing model, and analysis techniques in order to effectively deliver QoS requirements for those applications. Finally, we discuss our integration model to enhance the active capability of a DSMS.