gebhart/patrepeval huggingface dataset:
Measuring reaction kinetics in a lab-on-a-chip by microcoil NMR (2005)

A microfluidic chip with an integrated planar microcoil was developed for Nuclear Magnetic Resonance (NMR) spectroscopy on samples with volumes of less than a microliter. Real-time monitoring of imine formation from benzaldehyde and aniline in the microreactor chip by NMR was demonstrated. The reaction times in the chip can be set from 30 min down to ca. 2 s, the latter being the mixing time in the microfluidic chip. Design rules will be described to optimize the microreactor and detection coil in order to deal with the inherent sensitivity of NMR and to minimize magnetic field inhomogeneities and obtain sufficient spectral resolution.
The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me/me mutant mice (1999)

Naturally occuring inactivating mutations of the Src homology 2 (SH2) domain-containing tyrosine phosphatase 1 (SHP-1) in mice give rise to the motheaten (me) phenotype. me/me mice have multiple hematopoietic abnormalities, suggesting that this phosphatase plays an important role in hematopoiesis. SHP-1 binds to and is activated by several hematopoietic surface receptors, including the colony-stimulating factor type 1 receptor. We have examined the role of SHP-1 in osteoclastogenesis and osteoclast function using mice with the viable motheaten (mev/mev) mutation, which has markedly decreased SHP-1 activity. Histomorphometric analysis of 6-week-old mev/mev mice and control littermates showed a marked osteopenia with an increase in bone resorption indices. The number of formed osteoclast-like cells (OCLs) in cocultures of mev/mev hematopoietic cells with normal osteoblasts was significantly increased. In contrast, the number of OCLs formed in the coculture of normal bone marrow cells with the mev/mev osteoblasts was not significantly different from controls. The bone-resorbing activity of mev/mev OCLs and authentic osteoclasts was also found to be increased. Finally, Western blotting of proteins from mev/mev and control OCLs revealed an overall increase in tyrosine phosphorylation in the mev/mev lysates. These in vivo and in vitro results suggest that SHP-1 is a negative regulator of bone resorption, affecting both the formation and the function of osteoclasts.
Chemiluminescence detection using regenerable tris(2,2'-bipyridyl)ruthenium(II) immobilized in Nafion (1992)

The development of a detection method based on the electrogenerated chemiluminescence of tris(2,2'-bipyridine)ruthenium(II), (Ru(bpy)3(2+], immobilized in a Nafion film coated on an electrode is discussed. Control of the electrode potential controls creation of the reactive reagent Ru(bpy)3(3+) which reacts with certain analytes to yield chemiluminescence emission of intensity proportional to the analyte concentration. The reaction results in Ru(bpy)3(3+) being converted to Ru(bpy)3(2+), which then is recycled to Ru(bpy)3(3+) again at the electrode. This sensor has been used in flow injection to determine oxalate, alkylamines, and NADH. Detection limits are 1 microM, 10 nM, and 1 microM, respectively, with working ranges extending over 4 decades in concentration. Sensitivity is constant over the wide pH range from 3 to 10. With oxalate, and to a small extent with amines, emission intensities increase with increasing ionic strength; this was shown to be a phenomenon related to the Nafion film and not to the chemiluminescence reaction. Emission intensities increase with temperature. The sensor remains stable for several days with suitable storage conditions. Significant amounts of Ru(bpy)3(3+) are shown to be capable of storage within the film.
Rayleigh fading compensation for 16QAM using FFT (1999)

Pilot symbol-assisted modulation (PSAM) has been proposed to overcome the Rayleigh fading. However, as the fading rate becomes more rapid, it is difficult to provide an exact interpolation with conventional PSAM. To compensate for the fast Rayleigh fading, a PSAM which calculates in the frequency domain rather than the time domain as in conventional PSAM is proposed. Although this PSAM scheme only needs the zero interpolation for fading estimation, it provides a very accurate estimate even in relatively fast Rayleigh fading environments. We introduce this PSAM using fast Fourier transform (FFT) and apply it to 16QAM and then show some results of computer simulations.
Myelokathexis, a congenital disorder of severe neutropenia characterized by accelerated apoptosis and defective expression ofbcl-x in neutrophil precursors (2000)

Myelokathexis is a congenital disorder that causes severe chronic leukopenia and neutropenia. Characteristic findings include degenerative changes and hypersegmentation of mature neutrophils and hyperplasia of bone marrow myeloid cells. The associated neutropenia can be partially corrected by treatment with granulocyte colony-stimulating factor (G-CSF) or granulocyte–macrophage colony-stimulating factor (GM-CSF). These features led us to propose that accelerated apoptosis of neutrophil precursors might account for the neutropenic phenotype. Blood and bone marrow aspirates were obtained from 4 patients (2 unrelated families) with myelokathexis before G-CSF therapy and from 2 of the affected persons after G-CSF therapy (1 μg/kg per day subcutaneously for 3 weeks). Bone marrow was fractionated using immunomagnetic bead cell sorting into CD34+, CD33+/CD34−, and CD15+/CD34−/CD33− cell populations. Examination of these cells by flow cytometry and electron microscopy revealed abundant apoptosis in the CD15+ neutrophil precursor population, characterized by enhanced annexin-V binding, extensive membrane blebbing, condensation of heterochromatin, and cell fragmentation. Colony-forming assays demonstrated significant reduction in a proportion of bone marrow myeloid-committed progenitor cells. Immunohistochemical analysis revealed a selective decrease inbcl-x, but not bcl-2, expression in the CD15+/CD34−/CD33− cell population compared with similar subpopulations of control bone marrow-derived myeloid precursors. After G-CSF therapy, apoptotic features of patients' bone marrow cells were substantially reduced, and the absolute neutrophil counts (ANC) and expression ofbcl-x in CD15+/CD34−/CD33−cells increased. The authors concluded that myelokathexis is a disease characterized by the accelerated apoptosis of granulocytes and the depressed expression of bcl-x in bone marrow-derived granulocyte precursor cells. These abnormalities are partially corrected by the in vivo administration of G-CSF. (Blood. 2000;95:320-327)
Targeting of a chelating derivative of a short-chain analogue of α-melanocyte stimulating hormone to Cloudman S91 melanomas (1990)

Conference Article| October 01 1990 Targeting of a chelating derivative of a short-chain analogue of α-melanocyte stimulating hormone to Cloudman S91 melanomas DAVID R. BARD; DAVID R. BARD 1Strangeways Research Laboratory, Worts' Causeway, CB1 4RN, Cambridge U.K. Search for other works by this author on: This Site PubMed Google Scholar C. GRAHAM KNIGHT; C. GRAHAM KNIGHT 1Strangeways Research Laboratory, Worts' Causeway, CB1 4RN, Cambridge U.K. Search for other works by this author on: This Site PubMed Google Scholar D. PETER PAGE-THOMAS D. PETER PAGE-THOMAS 1Strangeways Research Laboratory, Worts' Causeway, CB1 4RN, Cambridge U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1990) 18 (5): 882–883. https://doi.org/10.1042/bst0180882 Article history Received: February 28 1990 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation DAVID R. BARD, C. GRAHAM KNIGHT, D. PETER PAGE-THOMAS; Targeting of a chelating derivative of a short-chain analogue of α-melanocyte stimulating hormone to Cloudman S91 melanomas. Biochem Soc Trans 1 October 1990; 18 (5): 882–883. doi: https://doi.org/10.1042/bst0180882 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: MSH, α-melanocyte stimulating hormone, DTPA, diethylenetriamine penta-acetic acid This content is only available as a PDF. © 1990 Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Effects of point singularities on shear-wave propagation in sedimentary basins (1991)

In most directions of propagation in anisotropic solids, seismic shear waves split in regular and predictable ways that, in principle, can be directly related to the degree of anisotropy and the anisotropic symmetry of the rockmass. In all anisotropic solids, however, there are directions of propagation, known as shear-wave singularities, where the split shear-waves have the same phase-velocities. For directions of propagation near the commonest type of singularity, the point singularity, the relationship between the phase and group-velocities may undergo rapid variations for small changes in direction. This results in shear-waves along rays (propagating at the group-velocity) behaving anomalously, with irregular polarizations and amplitude changes as if they were propagating near cusps, although the degree of anisotropy may be too small to cause conventional cusps on the group-velocity wave surfaces. The effects of propagation near such point singularities have been identified in sedimentary basins where they are features of the well-established phenomenon of azimuthal isotropy (transverse isotropy with a vertical axis of symmetry) caused by horizontal lithology, or by fine layering (PTL anisotropy), combining with the more recently recognized azimuthal anisotropy, caused by distributions of near-parallel near-vertical fluid-filled inclusions (EDA anisotropy). This paper demonstrates these irregular effects by calculating synthetic shear waves in directions near a point singularity in a material simulating a possible sedimentary basin. Such anomalies may be important in exploration seismology as point singularities can occur along nearly vertical ray paths in sedimentary basins. If not identified correctly, the effects of such point singularities could be mistakenly attributed to structural irregularities, and if correctly identified, the directions of such singularities can place tight constraints on possible combinations of PTL and EDA anisotropy in sedimentary basins.
<i>In vitro</i> and <i>in vivo</i> degradation of poly(1,3‐diamino‐2‐hydroxypropane‐<i>co</i>‐polyol sebacate) elastomers (2008)

Biomaterials with a wide range of tunable properties are desirable for application-specific purposes. We have previously developed a class of elastomeric poly(ester amides) based on the amine alcohol 1,3-diamino-2-hydroxypropane termed poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) or APS. In this work, we have synthesized and characterized formulations of APS polymers and studied the degradation of these polymers in vitro and in vivo. It was found that the chemical, physical, and mechanical properties of APS polymers could be tuned by adjusting monomer feed ratios and polymerization conditions. The degradation kinetics could also be greatly influenced by altering the formulation of APS polymers. In vivo degradation half-lives ranged from 6 to approximately 100 weeks. Furthermore, the dominant degradation mechanism (i.e. hydrolytic or enzymatic) could be controlled by adjusting the specific formulation of the APS polymer. On the basis of the observed in vitro and in vivo biodegradation phenomena, we also propose that the primary modes of degradation are composition dependent.
Direct evidence for increased pulmonary free radical generation in AMS and HAPE. (2007)

info:eu-repo/semantics/published
Heterogeneous meshing and biomechanical modeling of human spine (2006)

We aim to develop a patient-specific biomechanical model of human spine for the purpose of surgical training and planning. In this paper, we describe the development of a finite-element model of the spine from the VHD Male Data. The finite-element spine model comprises volumetric elements suitable for deformation and other finite-element analysis using ABAQUS. The mesh generation solution accepts segmented radiological slices as input, and outputs three-dimensional (3D) volumetric finite element meshes that are ABAQUS compliant. The proposed mesh generation method first uses a grid plane to divide the contours of the anatomical boundaries and its inclusions into discrete meshes. A grid frame is then built to connect the grid planes between any two adjacent planes using a novel scheme. The meshes produced consist of brick elements in the interior of the contours and with tetrahedral and wedge elements at the boundaries. The nodal points are classified according to their materials and hence, elements can be assigned different properties. The resultant spine model comprises a detailed model of the 7 cervical vertebrae, 12 thoracic vertebrae, 5 lumbar vertebrae, and S1. Each of the vertebrae and intervertebral disc has between 1200 and 6000 elements, and approximately 1200 elements, respectively. The accuracy of the resultant VHD finite element spine model was good based on visual comparison of volume-rendered images of the original CT data, and has been used in a computational analysis involving needle insertion and static deformation. We also compared the mesh generated using our method against two automatically generated models; one consists of purely tetrahedral elements and the other hexahedral elements.
A Rough Set-Based SVM Classifier for ATR on the Basis of Invariant Moment (2009)

Automatic target recognition (ATR) is an important task in image application. A classifier for the airplane recognition based on the merits of rough set theory (RST)and directed acyclic graph support vector machines (DAGSVM) is proposed in this paper. RST can mine useful information from a large number of data and generate decision rules without prior knowledge. DAGSVM have better classification performances than other SVMs methods and good capabilities of fault-tolerance and generalization. RST is used as preprocessing step to improve the performances of DAGSVM. Coupled together with RST and DAGSVM techniques they enable the ATR system to identify airplane type on the basis of certain shape feature sets in the images. The methods proposed are compared with general SVMs approach and are shown to perform somewhat better on the remote sensing images.
THE ROLE OF CHRISTIAN PHILOSOPHY IN THE GLOBAL AGE (2009)

Filsafat bergulir seiring dengan zaman. Inilah hakikat filsafat, ia mengalir sepanjang aliran sungai peradaban manusia membawanya. Atau, dinamika filsafat mengawal sekaligus mengarahkan dinamisme perkembangan sejarah kehidupan. Dinamika filsafat Kristiani diawali dengan perspektif baru dalam membaca filsafat Aristotelian. Tidak hanya dari Thomas Aquinas kita mewarisi perspektif Kristiani di dunia filsafat, tetapi juga dari Nicholas de Cusa kita memiliki purifikasi terminologi semacam “the single and the individual” atau “the whole”. Zaman kini telah bergulir kepada “global age”. Pertanyaan dasar yang diajukan dalam artikel ini: Apa peranan filsafat Kristiani di dunia global? Penulis dengan melakukan studi panoramik mengajukan beberapa tesis pandangan. Pertama, filsafat Kristiani mesti mewujud dalam sosok-sosok yang mampu menyatukan peradaban. Filsafat Kristiani perlu melampaui perdebatan dari level terminologis kepada upaya-upaya konkret personal eksistensial untuk membangun peradaban baru. Yohanes Paulus II harus disebut sebagai salah satu sosok partisipatif “beyond” terminologi filosofis Kristiani. Ia menghadirkan “sense of unity” dari peradaban zaman ini.
Synthesis of (1<i>R</i>,4<i>S</i>,5<i>R</i>)‐<i>endo‐N,N</i>‐dimethyl‐2‐azabicyclo[2.2.1]methanamine (1991)

Abstract Starting from trans ‐4‐hydroxy‐L‐proline, (1 R ,4 S ,5 R )‐ endo‐N,N ‐dimethyl‐2‐azabicyclo[2.2.1]methanamine 1 has been synthesized. The target compound is precursor of antibacterial quinolone carboxylic acids.
Electron—hydrogenlike-ion scattering (1982)

The $s$-, $p$-, and $d$-wave phase shifts have been calculated for elastic scattering of electrons by hydrogenlike ions ${\mathrm{He}}^{+}$, ${\mathrm{Li}}^{2+}$, ${\mathrm{Be}}^{3+}$, and ${\mathrm{B}}^{4+}$ with the use the polarized-orbital method of Callaway et al. The present method takes account of exchange polarization explicitly following Sloan. Our $s$-wave triplet phase shifts are in very good agreement with those of the variational method. In the case of ${e}^{\ensuremath{-}}$-${\mathrm{He}}^{+}$ scattering, our singlet $s$-wave phase shifts differ by about 7.5% whereas for ${e}^{\ensuremath{-}}$-${\mathrm{B}}^{4+}$ scattering, agreement is very good.
34.3: Quasi‐ and Analog‐Full‐Color Displaying Methods with High Light Efficiency in Super‐High‐Resolution LCDs (2004)

Abstract A new coloring method of LCD (liquid crystal display) using the hybrid structure of CF (color filter) method and the interference coloration of ECB (electrically controlled birefringence) effect is presented. One unit pixel is divided into at least two sub‐pixels, and the one sub‐pixel is equipped with a green CF and the other one a magenta CF. As for the green coloration of the highest luminosity property, a green CF is used in order to display the analogue gray scale. The interference coloration of ECB effect with a magenta CF is used for red and blue binary coloration as well as analogue gray scale of the magenta color. Monochrome gray scale can be realized by the additive color mixing of green and magenta sub‐pixels. The VA (vertical alignment) mode is adopted for suppressing the temperature dependence of the optical retardation. We can achieve much better light efficiency than that of the conventional color LCDs with both an RGB‐CF and a polarizer. This mode has the features of quasi‐full color and wide color space for red and blue color by the subtractive color mixing effect between interference coloration and magenta CF. Furthermore, the present LCD can be fabricated without changing the conventional LCD process and materials. We also present the analog‐full‐color method, which can be realized by using small additive sub‐pixels of red and blue colors.
Milling of Brittle and Ductile Materials (2015)

Abstract Milling of materials, whether hard and brittle or soft and ductile, is of prime interest and of economic importance to the powder metallurgy (PM) industry. This article discusses the principles of milling, milling parameters, and the powder characteristics required for the process. It discusses the changes in powder particle morphology that occur during milling of metal powders produced by various processes such as microforging, fracturing, agglomeration, and deagglomeration. The article also provides useful information on milling equipment such as tumbler ball mills, vibratory ball mills, attrition mills, and hammer and rod mills.
A Unified Approach to Personalization Based on Probabilistic Latent Semantic Models of Web Usage and Content (2004)

Web usage mining techniques, such as clustering of user sessions, are often used to identify Web user access patterns. However, to understand the factors that lead to common navigational patterns, it is necessary to develop techniques that can automatically characterize users’ navigational tasks and intentions. Such a characterization must be based both on the common usage patterns, as well as on common semantic information associated with the visited Web resources. The integration of semantic content and usage patterns allows the system to make inferences based on the underlying reasons for which a user may or may not be interested in particular items. In this paper, we propose a unified framework based on Probabilistic Latent Semantic Analysis to create models of Web users, taking into account both the navigational usage data and the Web site content information. Our joint probabilistic model is based on a set of discovered latent factors that “explain” the underlying relationships among pageviews in terms of their common usage and their semantic relationships. Based on the discovered user models, we propose algorithms for characterizing Web user segments and to provide dynamic and personalized recommendations based on these segments. Our experiments, performed on real usage data, show that this approach can more accurately capture users’ access patterns and generate more effective recommendations, when compared to more traditional methods based on clustering.
Determining effect of irrigation water use on groundwater quality and drainage. (2010)

This work was carried out in Akarsu Irrigation District (AID) of 9 495 hectares. Drainage and groundwater salinity problems developed due to mismanaged irrigation systems, low irrigation efficiency, heavy soil texture, inadequate drainage systems and other likely problems which all cause reduced agricultural production. The undertaken work investigates interrelations between the existing irrigation practice with groundwater depths and salinity, using groundwater observation wells. With additionally installed drainage observation wells, a total of 107 wells were under survey in 2006. The groundwater depths were measured in May and July and samples were collected concurrently for measuring electrical conductivity (EC, dS m-1). The groundwater depths in May showed that there was no drainage problem in the area. However, drainage problem (ground water depth &amp;lt; 1 m) was evident during high irrigation season in July. Mean groundwater salinity in May and July were respectively 4.3±10.1 and 2.8±4.3 dS m-1. The high groundwater salinity observed during the peak irrigation season in July was attributed to wide spread practice of excess irrigation resulting both low field irrigation efficiency and low irrigation water use efficiency
Randomized phase II study of weekly paclitaxel versus paclitaxel and carboplatin as second-line therapy in disseminated melanoma (2003)

Stage melanoma IV has a poor prognosis, with a median survival time between 3 and 11 months from the diagnosis of distant metastases. Response rates in first-line regimens are around 20%. To date, no second-line treatment has been established. We performed a randomized, multicentre, second-line clinical phase II study of paclitaxel either as monotherapy or combined with carboplatin given on an outpatient basis. In arm A, paclitaxel was administered at a dose of 100 mg/m2 intravenously on day 1 each week for 6 weeks. In arm B, paclitaxel was administered at a dose of 80 mg/m2 intravenously followed by carboplatin 200 mg/m2 on day 1 each week for 6 weeks. The next cycle was administered after a 2 week intermission. The response rate, survival time, time-to-progression and toxicity were assessed in both arms. The study was stopped after 40 patients because the overall response rate was below 10% in both arms. The median survival time after initiation of second-line treatment was 209 days (+/- 196 days) for patients treated with paclitaxel only, and 218 days for those treated with paclitaxel/carboplatin. The median time-to-progression was around 56 days in both arms. Two partial responses were observed after 16 weeks, lasting for 8 and 12 weeks, respectively. Although both treatment modalities were well tolerated, haematological toxicity was higher in the combination arm. This is so far the largest second-line clinical phase II study reported in melanoma. However, paclitaxel with or without carboplatin had only limited efficacy, and the combination of these drugs adds significantly to haematological toxicity without improving response or survival rates.