gebhart/patrepeval huggingface dataset:
Influence of the primary emulsification procedure on the characteristics of small protein-loaded PLGA microparticles for antigen delivery (2006)

Microparticles prepared from poly(lactic-co-glycolic acid) (PLGA) using a W1/O/W2 double emulsion solvent evaporation method are suitable vehicles for the delivery of proteins to antigen presenting cells, e.g. dendritic cells. In this study, the influence of different techniques for the preparation of the primary W1/O emulsion was investigated with respect to the protein localization within the microparticles, morphological characteristics of these particles, protein burst release and the native state of the released protein. Bovine serum albumin bearing fluorescein isothiocyanate (FITC-BSA) was used as model protein. A static micromixer was applied for the preparation of the W1/O/W2 double emulsion. Employing a rotor-stator homogenizer (Ultra-Turrax) for primary emulsification, microcapsules with a high burst release were produced, because nearly all FITC-BSA was attached to the outside of the particle wall. Using a high pressure homogenizer or an ultrasonic procedure resulted in the formation of microspheres with homogeneous protein distribution and a reduced burst release.
Privatization and Restructuring in Central and Eastern Europe (1997)

One of the most important policy questions in the transition economies is what governments can do to speed the restructuring of firms and thus hasten the transition to a mature market economy. The authors report on a study that provides some answers. Privatization encourages restructuring if it is rapid and comprehensive and leads to concentrated ownership. Privatization also promotes restructuring because privatized firms are more likely than state-owned enterprises to exercise wage restraint--and wage restraint is vital to free up the necessary internal finance. But policies that increase bank lending to firms, such as debt forgiveness and recapitalization, may do more harm than good. The safest course is to recapitalize banks only as part of privatization and to encourage negotiations for financial restructuring only after the banks are privatized.
Electrospun Activated Carbon Nanofibers Electrodes Based on Polymer Blends (2009)

Activated carbon nanofibers (ACNFs) based on a polymer blend, which consists of polyacrilonitrile (PAN) and cellulose acetate (CA), were prepared by electrospinning and subsequent thermal treatment. The diameter of ACNF increased with increasing CA content. The electrical conductivity increased with the addition of CA due to a larger oxygen amount of CA molecules. The specific surface area and average pore diameter of CA-free ACNF (CP) were and , respectively, while those of CA-blended ACNF (15CP) increased to and , respectively. The capacitance of CP was at , whereas that of 15CP increased to . This is why the CP is predominated by small surface area with microporosity, whereas the 15CP is affected by higher surface area with better mesoporosity due to the combination of electrospinning based on polymer blends and thermal treatment.
Design of modified oligodeoxyribonucleotide probes to detect telomere repeat sequences in FISH assays (1999)

A series of dye-labeled oligonucleotide probes containing base and sugar modifications were tested for the ability to detect telomeric repeat sequences in FISH assays. These modified oligonucleotides, all 18 nt in length, were complementary to either the cytidine-rich (C(3)TA(2))(n)or guanosine-rich (T(2)AG(3))(n)telomere target sequences. Oligonucleotides were modified to either increase target affinity by enhancing duplex stability [2'-OMe ribose sugars and 5-(1-propynyl)pyrimidine residues] or inhibit the formation of inter- or intramolecular structures (7-deazaguanosine and 6-thioguanosine residues), which might interfere with binding to the target. Several dye-labeled oligonucleotide probes were found that could effectively stain the telomeric repeat sequences of either cytidine- or guanosine-rich strands in a specific manner. Such probes could be used as an alternative to peptide nucleic acids for investigating the dynamics of telomere length and maintenance. In principle, these relatively inexpensive and readily synthesized modified oligonucleotides could be used for other FISH-related assays.
The Hybrid Cycle: Integration of Turbomachinery With a Fuel Cell (1999)

In the deregulated electric utility environment, distributed power is expected to play a major role in meeting national power generation requirements of the 21st century. Compliance with environmental regulations and ultra-high efficiency will be attributes in penetrating distributed power markets. Fuel cell/turbomachinery hybrids are poised to become the first choice for these applications, yielding emissions of nitrogen oxides below 2 ppmv and low CO2 emissions due to high efficiency (>70% in 20 MW power packages). The challenges faced by hybrid systems are: system integration, power electronics/power conditioning, system controls, operational and transient dynamics, and commercial system cost. Opportunities to use existing gas turbines as the selected turbomachinery are being investigated, prompted by size flexibility and the savings in time and investment that this offers. This paper is an attempt to address the opportunities and challenges posed by a variety of fuel cell/turbomachinery hybrids.
Modeling of STDR system for locating faults in live aircraft wires (2013)

Wiring problems in aging aircraft have been identified as the cause of several tragic mishaps and hundreds of thousands of lost mission hours. Intermittent wiring faults, which occur during flight, have been and continue to be difficult to resolve. This makes it necessary to monitor live aircraft wires continuously, without affecting the aircraft signals on live wires. Monitoring of live aircraft wires can be accomplished by various Reflectometry methods. Sequence Time Domain Reflectometry (STDR) is one of the Time Domain Reflectometry methods for detecting discontinuities on live wires carrying signals or data, without disturbing them. In this paper, we have modeled this STDR system using MATLAB coding and interfacing with the Simulink blocks. This model prototypes the STDR method along with correlation to detect either open or short circuits.
Real-time measurement of traffic queue parameters by using image processing techniques (1995)

The real-time measurement of traffic queue parameters are required in many traffic situations such as accident and congestion monitoring and adjusting the timings of the traffic lights. So far the reported image processing methods have been targeted for measuring simple traffic parameters. The present authors describe image processing techniques together with the results to measure the queue traffic parameters in real-time. The proposed queue detection algorithm consists of a motion detection and vehicle detection operation, both based on extracting edges of the scene. The results show that the proposed algorithms are able to measure various queue parameters such as queue detection, length of the queue, period of the occurrence of the queue, slope of the queue etc.
T<sub>3</sub>increases lactate transport and the expression of MCT4, but not MCT1, in rat skeletal muscle (2003)

Triiodothyronine (T3) regulates the expression of genes involved in muscle metabolism. Therefore, we examined the effects of a 7-day T3 treatment on the monocarboxylate transporters (MCT)1 and MCT4 in heart and in red (RG) and white gastrocnemius muscle (WG). We also examined rates of lactate transport into giant sarcolemmal vesicles and the plasmalemmal MCT1 and MCT4 in these vesicles. Ingestion of T3 markedly increased circulating serum T3 (P < 0.05) and reduced weight gain (P < 0.05). T3 upregulated MCT1 mRNA (RG +77, WG +49, heart +114%, P < 0.05) and MCT4 mRNA (RG +300, WG +40%). However, only MCT4 protein expression was increased (RG +43, WG +49%), not MCT1 protein expression. No changes in MCT1 protein were observed in any tissue. T3 treatment doubled the rate of lactate transport when vesicles were exposed to 1 mM lactate (P < 0.05). However, plasmalemmal MCT4 was only modestly increased (+13%, P < 0.05). We conclude that T3 1) regulates MCT4, but not MCT1, protein expression and 2) increases lactate transport rates. This latter effect is difficult to explain by the modest changes in plasmalemmal MCT4. We speculate that either the activity of sarcolemmal MCTs has been altered or else other MCTs in muscle may have been upregulated.
Use of a Machine Learning Algorithm to Classify Expertise (2014)

The results confirmed the hypothesis. The SVM algorithm increased the predictive power to classify blinded surgical hand motion patterns into expert versus novice groups. With further development, the system used in this study could become a viable tool for low-cost, objective assessment of procedural proficiency in a competency-based curriculum.
Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase (2008)

Fatty Acid Synthase (FASN), a cytoplasmic biosynthetic enzyme, is the major source of long-chain fatty acids, particularly palmitate. Caveolin-1 (Cav-1) is a palmitoylated lipid raft protein that plays a key role in signal transduction and cholesterol transport. Both proteins have been implicated in prostate cancer (PCa) progression, and Cav-1 regulates FASN expression in a mouse model of aggressive PCa. We demonstrate that FASN and Cav-1 are coordinately upregulated in human prostate tumors in a hormone-insensitive manner. Levels of FASN and Cav-1 protein expression discriminated between localized and metastatic cancers, and the two proteins exhibited analogous subcellular locations in a tumor subset. Endogenous FASN and Cav-1 were reciprocally co-immunoprecipitated from human and murine PCa cells, indicating that FASN forms a complex with Cav-1. FASN, a cytoplasmic enzyme, was induced to associate transiently with lipid raft membranes following alterations in signal transduction within the Src, Akt and EGFR pathways, suggesting that co-localization of FASN and Cav-1 is dependent on activation of upstream signaling mediators. A Cav-1 palmitoylation mutant, Cav-1(C133/143/156S), that prevents phosphorylation by Src, did not interact with FASN. When overexpressed in Cav-1-negative PCa cells, Cav-1(C133/143/156S) caused a reduction of both Src and Akt levels, as well as of their active, phosphorylated forms, in comparison with wild type Cav-1. These findings suggest that FASN and Cav-1 physically and functionally interact in PCa cells. They also imply that palmitoylation within this complex is involved in tumor growth and survival.
Promising Electrochemiluminescence from CuInS<sub>2</sub>/ZnS Nanocrystals/Hydrazine via Internal Cu(I)/Cu(II) Couple Cycling (2019)

Screening a novel electrochemiluminescence (ECL) system is crucial to ECL evolution. Herein, an efficient ECL system with less interference and environmental concern under physiological condition is developed via a unique internal Cu(I)/Cu(II) couple cycling amplified strategy by employing the glutathione- and citrate-capped copper indium sulfide (CIS)/ZnS nanocrystals (NCs) as electrochemiluminophore and N<sub>2</sub>H<sub>4</sub>·H<sub>2</sub>O as co-reactant. CIS/ZnS NCs can be electrochemically injected with valence band (VB) hole at 0.46 and 0.87 V (vs Ag/AgCl), and then achieve the same hole-injected states by relocalizing VB holes with the Cu(I) species inside of CIS/ZnS NCs to form internal Cu(II) defects, while each N<sub>2</sub>H<sub>4</sub>·H<sub>2</sub>O molecule can be successively oxidized to two more reducing species N<sub>2</sub>H<sub>3</sub><sup>•</sup> and N<sub>2</sub>H<sub>2</sub> around 0.10 V, and inject conduction band (CB) electron onto CIS/ZnS NCs for triple times. The internal Cu(I)/Cu(II) couple cycling involved radiative-charge recombination between these VB hole and CB electron eventually enables two efficient near-infrared ECL processes (around 731 nm) at 0.55 and 0.87 V, in which each single nanocrystal may participate in multiple ECL reaction cycles to produce multiple photons for amplified ECL, similar to the tris(bipyridyl)ruthenium(III) based ECL system. The low-triggering-potential ECL process at 0.55 V can be utilized to selectively determine Cu(II) with a wide linear range from 10 and 1500 nM and a limit of detection of 5 nM (<i>S</i>/<i>N</i> = 3). This work presents a NCs engineering and co-reactant selecting combined strategy for further ECL evolution.
Pyrolysis of phenylalkylsulphonyl azides and 2-phenethyl azidoformate. Selectivity of sulphonylnitrenes and contrast between sulphonyl- and carbonyl-nitrenes (1981)

Flash vacuum pyrolysis and solution thermolysis of Ph[CH2]nSO2N3 indicate that intramolecular addition to the phenyl group is preferred in solution, provided that up to an eight-membered sultam ring is formed, otherwise side-chain insertion results, while in the gas phase the latter process is favoured when n= 4,5, but not 3; some 5,6,7,8-tetrahydroquinoline is obtained when n= 3 at 990 °C, but 2-phenethyl azidoformate gave monomeric tetrahydro-1, 3-oxazino [3,4-a] azepin-2-one and 4-phenyl-oxazolidinone, but no dihydrocyclopenta [b] pyridine, even at 990 °C.
Preparation and characterization of LDPE and PP—Wood fiber composites (2009)

Abstract Natural fiber reinforced composites is an emerging area in polymer science. These natural fibers are low cost fibers with low density and high specific properties. These are biodegradable and nonabrasive. The natural fiber composites offer specific properties comparable to those of conventional fiber composites. However, in development of these composites, the incompatibility of the fibers and poor resistance to moisture often reduce the potential of natural fibers, and these draw backs become critical issue. Wood‐plastic composites (WPC) are a relatively new class of materials and one of the fastest growing sectors in the wood composites industry. Composites of wood in a thermoplastic matrix (wood–plastic composites) are considered a low maintenance solution to using wood in outdoor applications. WPCs are normally made from a mixture of wood fiber, thermoplastic, and small amounts of process and property modifiers through an extrusion process. In this study, Wood–plastic composites (WPC) are produce by adding a maleic anhydride modified low density polyethylene coupling agent to improve interfacial adhesion between the wood fiber and the plastic. Mixing is done with twin screw extruder. Subsequently, tensile strength, the modulus of elasticity, % elongation, hardness, Izod impact strength, melt flow index (MFI), and heat deflection temperature (HDT) are determined. Thermal transition temperatures and microstructure are determined with DSC and SEM, respectively. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Synthesis and Pharmacologic Evaluation of 2-<i>endo</i>-Amino-3-<i>exo</i>- isopropylbicyclo[2.2.1]heptane:  A Potent Imidazoline<sub>1</sub> Receptor Specific Agent (1996)

ADVERTISEMENT RETURN TO ISSUELetterNEXTSynthesis and Pharmacologic Evaluation of 2-endo-Amino-3-exo- isopropylbicyclo[2.2.1]heptane: A Potent Imidazoline1 Receptor Specific AgentStephen A. Munk, Ronald K. Lai, James E. Burke, Premilla N. Arasasingham, Alexander B. Kharlamb, Cynthia A. Manlapaz, Edwin U. Padillo, Mercy K. Wijono, Dain W. Hasson, Larry A. Wheeler, and Michael E. GarstView Author Information Allergan Pharmaceuticals, 2525 Dupont Drive, Irvine, California 92715 Cite this: J. Med. Chem. 1996, 39, 6, 1193–1195Publication Date (Web):March 15, 1996Publication History Received3 January 1996Published online15 March 1996Published inissue 15 March 1996https://pubs.acs.org/doi/10.1021/jm960012ohttps://doi.org/10.1021/jm960012orapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views588Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Agonists,Anatomy,Assays,Receptors,Screening assays Get e-Alerts
The Marketing Code (2006)

Death stalks the streets of Edinburgh, as marketing lecturer Simon Magill receives a gruesome message about a mysterious website. He is plunged into a marketing maelstrom that sweeps from the glitz of Las Vegas to the grime of West Belfast, taking in the Freemasons, the Knights Templar, the conspiracies surrounding the sinking of the Titanic and, not least, the insidious marketing campaign behind Dan Brown’s blockbuster novel, The Da Vinci Code .As Simon Magill struggles to make sense of the riddle, he uncovers a startling truth about the irredeemably commercial character of the Holy Grail. Racing against time, he discovers that there is, and always has been, a cabal at the heart of Western capitalism – a secret society that possesses the key to business success. Based at a prominent American business school, this clandestine organisation has been systematically misleading the marketing community for millennia. As Magill soon discovers, it will stop at nothing to prevent its jealously guarded secret being revealed...
On-Site Acoustic-Emission Monitoring for a Prestressed Concrete BT-54 AASHTO Girder Bridge (2020)

Acoustic emission (AE) data were investigated to better understand damage conditions in a three-span prestressed concrete girder bridge during a load test. The innovation lies in classification of crack extensions (stable or unstable) during the loading and holding processes. The gap in current literature addressed is a shortage of data and findings on bridges in operation and having inclined cracks. This manuscript addresses processing of AE signals recorded by piezoelectric sensors attached on two interior girders toward the obtuse corner of the bridge while under loading. Results showed indications of crack propagation beyond the existing cracks during both loading and load holds. Damage classification procedures based on AE data recorded during one loading and holding step are discussed. Shear strength analysis using modified compression field theory (MCFT) was performed to place the results in the context of potential overloads.
Pore Narrowing and Formation of Ultrathin Yttria‐Stabilized Zirconia Layers in Ceramic Membranes by Chemical Vapor Deposition/Electrochemical Vapor Deposition (1993)

Chemical vapor deposition (CVD) and electrochemical vapor deposition (EVD) have been applied to deposit yttria‐stabilized‐zirconia (YSZ) on porous ceramic media. The experimental results indicate that the location of YSZ deposition can be varied from the surface of the substrates to the inside of the substrates by changing the CVD/EVD experimental conditions, i.e., the concentration ratio of the reactant vapors. The deposition width is strongly dependent on the deposition temperature used. The deposition of YSZ inside the pores resulted in pore narrowing and eventually pore closure, which was measured by using permpor‐ometry. However, deposition of YSZ on top of porous ceramic substrates (outside the pores) did not result in a reduction of the average pore size. Ultrathin, dense YSZ layers on porous ceramic substrates can be obtained by suppressing the EVD layer growth process after pore closure.
A quantitative model for charge carrier transport, trapping and recombination in nanocrystal-based solar cells (2015)

Improving devices incorporating solution-processed nanocrystal-based semiconductors requires a better understanding of charge transport in these complex, inorganic-organic materials. Here we perform a systematic study on PbS nanocrystal-based diodes using temperature-dependent current-voltage characterization and thermal admittance spectroscopy to develop a model for charge transport that is applicable to different nanocrystal-solids and device architectures. Our analysis confirms that charge transport occurs in states that derive from the quantum-confined electronic levels of the individual nanocrystals and is governed by diffusion-controlled trap-assisted recombination. The current is limited not by the Schottky effect, but by Fermi-level pinning because of trap states that is independent of the electrode-nanocrystal interface. Our model successfully explains the non-trivial trends in charge transport as a function of nanocrystal size and the origins of the trade-offs facing the optimization of nanocrystal-based solar cells. We use the insights from our charge transport model to formulate design guidelines for engineering higher-performance nanocrystal-based devices.
From DataGlove to DataSuit (1988)

The development of an interface system that captures, records, and renders to the movement of the human body is reported. Sensors on the DataSuit, a garment covering the body from neck to ankles, register the position and orientation of the joints of the body. An absolute positioning system tracks the movement of the individual in six degrees of freedom within the room is reported. Applications of the DataSuit include use as a user input device for teleoperation, telepresence, human performance modeling, and animation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain (2014)

Involvement of endothelial pathways in functional neurovascular coupling provides new explanations for the spatial and temporal features of the hemodynamic response to stimulus and could explain previous results that were interpreted as evidence for astrocyte-mediated control of functional hyperemia. Our results unify many aspects of blood flow regulation in the brain and body and prompt new investigation of direct links between systemic cardiovascular disease and neural deficits.