gebhart/patrepeval huggingface dataset:
The Glass Cockpit ‐Displays for Multi‐Colour Presentation of Large Quantities of Information (1986)

FAULTLESS, error‐free communication between man and machine, as well as between individual assemblies is of vital importance for reliable aircraft operation. The term ‘man/machine communication’ is interpreted in this context as the output of information offered by the aircraft equipment and the entry of commands and information in the aircraft system by the human operator. Machine/machine communication, on the other hand, means integrated operation of the individual subsystems of the aircraft.
Herpes Simplex Virus Tegument Protein VP22 Contains Overlapping Domains for Cytoplasmic Localization, Microtubule Interaction, and Chromatin Binding (2002)

We have previously shown that the 301-amino-acid herpes simplex virus tegument protein VP22 exhibits a range of subcellular localization patterns when expressed in isolation from other virus proteins. By using live-cell analysis of cells expressing green fluorescent protein (GFP)-tagged VP22 we have shown that when VP22 is first expressed in the cell it localizes to the cytoplasm, where, when present at high enough concentrations, it can assemble onto microtubules, causing them to bundle and become highly stabilized. In addition we have shown that when a cell expressing VP22 enters mitosis, the cytoplasmic population of VP22 translocates to the nucleus, where it efficiently binds mitotic chromatin. Here we have investigated the specific regions of the VP22 open reading frame required for these properties. Using GFP-VP22 as our starting molecule, we have constructed a range of N- and C-terminal truncations and analyzed their localization patterns in live cells. We show that the C-terminal 242 residues of VP22 are sufficient to induce microtubule bundling. Within this subregion, the C-terminal 89 residues contain a signal for cytoplasmic localization of the protein, while a larger region comprising the C-terminal 128 residues of the VP22 protein is required for mitotic chromatin binding. Furthermore, a central 100-residue domain of VP22 maintains the ability to bind microtubules without inducing bundling, suggesting that additional regions flanking this microtubule binding domain may be required to alter the microtubule network. Hence, the signals involved in dictating the complex localization patterns of VP22 are present in overlapping regions of the protein.
The OBF1 protein and its DNA-binding site are important for the function of an autonomously replicating sequence in Saccharomyces cerevisiae. (1989)

The autonomously replicating sequence ARS121 was cloned as a 480-base-pair (bp) long DNA fragment that confers on plasmids autonomous replication in Saccharomyces cerevisiae. This fragment contains two OBF1-binding sites (sites I and II) of different affinities, as identified by a gel mobility shift assay and footprint analysis. Nucleotide substitutions (16 to 18 bp) within either of the two sites obliterated detectable in vitro OBF1 binding to the mutagenized site. Linker substitution (6 bp) mutations within the high-affinity site I showed effects similar to those of the complete substitution, whereas DNA mutagenized outside the binding site bound OBF1 normally. We also tested the mitotic stability of centromeric plasmids bearing wild-type and mutagenized copies of ARS121. Both deletion of the sites and the extensive base alterations within either of the two OBF1-binding sites reduced the percentage of plasmid-containing cells in the population from about 88% to 50 to 63% under selective growth and from about 46% to 15 to 20% after 10 to 12 generations of nonselective growth. Furthermore, linker (6 bp) substitutions within site I, the high-affinity binding site, showed similar deficiencies in plasmid stability. In contrast, plasmids containing linker substitutions in sequences contiguous to site I displayed wild-type stability. In addition, plasmid copy number analysis indicated that the instability probably resulted not from nondisjunction during mitosis but rather from inefficient plasmid replication. The results strongly support the notion that the OBF1-binding sites and the OBF1 protein are important for normal ARS function as an origin of replication.
Airfoil sampling of a pulsed Laval beam with tunable vacuum ultraviolet synchrotron ionization quadrupole mass spectrometry: Application to low-temperature kinetics and product detection (2011)

A new pulsed Laval nozzle apparatus with vacuum ultraviolet (VUV) synchrotron photoionization quadrupole mass spectrometry is constructed to study low-temperature radical-neutral chemical reactions of importance for modeling the atmosphere of Titan and the outer planets. A design for the sampling geometry of a pulsed Laval nozzle expansion has been developed that operates successfully for the determination of rate coefficients by time-resolved mass spectrometry. The new concept employs airfoil sampling of the collimated expansion with excellent sampling throughput. Time-resolved profiles of the high Mach number gas flow obtained by photoionization signals show that perturbation of the collimated expansion by the airfoil is negligible. The reaction of C(2)H with C(2)H(2) is studied at 70 K as a proof-of-principle result for both low-temperature rate coefficient measurements and product identification based on the photoionization spectrum of the reaction product versus VUV photon energy. This approach can be used to provide new insights into reaction mechanisms occurring at kinetic rates close to the collision-determined limit.
Enhanced IPv6 ping and traceroute (2012)

Ping and Traceroute utility has been a fundamental tool for a network service provider or an enterprise network operator to run its IPv4 network for various kinds of services, data/voice/video. However, it's known the returned result from IPv4 ping/traceroute tool cannot tell whether any link in a packet's path to its destination is congested. In this paper, a proposal to enhance IPv6 ping/traceroute utility is presented. The returned results of the enhanced IPv6 traceroute utility will carry information on link utilization of each intermediate hop. The information is particularly useful for Internet traffic crossing multiple autonomous systems and being sensitive to network congestion. Over-the-top video delivery and IP audio/video conferences are examples of QoS sensitive traffic crossing multiple ASNs in internet. The link utilization information from the enhanced IPv6 ping/traceroute tool can also be used in a measurement-based approach for dynamic QoS adaptation in wired-wireless networks. The enhanced ping/traceroute utility can also inform its user on the autonomous system number (ASN), interface ID and host/domain name of each intermediate hop. The latter capability will deem DNS and/or whois database queries based on returned IPv6 address unnecessary. In fact, the enhanced utility can be used to tell if DNS entry of a router interface is correct in DNS database. Error in DNS entry of a router interface is common due to re-IP, network migration or merger. It's known that DNS error can mislead a network operator when trouble shooting a network connectivity failure.
DNAH5 Mutations Are a Common Cause of Primary Ciliary Dyskinesia with Outer Dynein Arm Defects (2020)

Rationale: Primary ciliary dyskinesia (PCD) is characterized by recurrent airway infections and randomization of left–right body asymmetry. To date, autosomal recessive mutations have only been identified in a small number of patients involving DNAI1 and DNAH5, which encode outer dynein arm components.
Neuronal antinuclear antibody (anti-Hu) in paraneoplastic encephalomyelitis simulating acute polyneuritis (1987)

A patient with paraneoplastic encephalomyelitis (PEM) and small cell lung cancer had a clinical presentation of acute polyneuritis. The patient had an antibody (anti-Hu) restricted to nuclei of neurons identical to that reported in patients with subacute sensory neuronopathy and lung cancer. This finding further supports the hypothesis that PEM and subacute sensory neuronopathy are closely related disorders of autoimmune origin. PEM should be considered in patients with small cell lung cancer and clinical features limited to the peripheral nervous system.
Biologically inspired intelligent decision making (2013)

Artificial neural networks (ANNs) are a class of powerful machine learning models for classification and function approximation which have analogs in nature. An ANN learns to map stimuli to responses through repeated evaluation of exemplars of the mapping. This learning approach results in networks which are recognized for their noise tolerance and ability to generalize meaningful responses for novel stimuli. It is these properties of ANNs which make them appealing for applications to bioinformatics problems where interpretation of data may not always be obvious, and where the domain knowledge required for deductive techniques is incomplete or can cause a combinatorial explosion of rules. In this paper, we provide an introduction to artificial neural network theory and review some interesting recent applications to bioinformatics problems.
The Man Who Lived for Tomorrow: A Biography of William Hallock Park, M. D (1942)

Journal Article The Man Who Lived for Tomorrow: A Biography of William Hallock Park, M. D Get access The Man Who Lived for Tomorrow: A Biography of William Hallock Park, M. D. By Wade W. Oliver. Cloth. Price, $3.75. Pp. 507, with portrait. New York: E. P. Dutton & Co., Inc., 1941. Physical Therapy, Volume 22, Issue 2, March 1942, Page 122, https://doi.org/10.1093/ptj/22.2.122c Published: 01 March 1942
Revisiting the <i>Hinsberg</i> Reaction: Facile and Expeditious Synthesis of 3‐Substituted Quinoxalin‐2(1<i>H</i>)‐ones under Catalyst‐Free Conditions in Water (2010)

Abstract Substituted benzene‐1,2‐diamine reacted with various α ‐keto esters at 50° under mild conditions for 15 min using H 2 O as reaction medium, providing a variety of 3‐substituted quinoxalinone derivatives in excellent yields. The reaction was instantaneous, and products were isolated by simple filtration.
Packaging of a reflective optical duplexer based on silicon micromechanics (2002)

We present a fully packaged duplexer implementing a reflective Fabry-Perot modulator realised by silicon surface micromachining. The device demonstrates excellent performance for bit rates up to 2.8 Mbit/s. Relaxed positioning tolerances, a fiber to fiber loss below 3 dB, an extinction ratio better than 12 dB, and the potential for low cost fabrication make this device very attractive for use in economical optical links.
A Authentication and Access Authorization Mechanism on the PaaS Platform (2019)

Security of Platform as a Service for multi-tenant becomes a key factor for the sustainable development of the system. This paper analyzes the limitations and shortcomings of traditional identity authentication. Identity authentication is realized through the ticket authentication method. Considering the dynamic and timeliness of resources in cloud computing, this paper proposes a dynamic access control method based on Role-Based Access Control and usage control model from the perspective of business conversation, so as to realize the dynamic access control of tenants to resources in Platform as a Service. The paper elaborates on the security and usability of the key generation, distribution, update, and metadata access control processes. Practice shows that the cloud resource access control model can flexibly realize the control of cloud resources such as authority separation, resource attribute restriction and utilization control, so as to better meet the demand of cloud resource access control with multi-tenant sharing and dynamic characteristics in cloud environment.
Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease (2007)

Microglial activation is a key feature in Alzheimer's disease and is considered to contribute to progressive neuronal injury by release of neurotoxic products. The innate immune receptor Toll-like-receptor 4 (TLR4), localized on the surface of microglia, is a first-line host defense receptor against invading microorganisms. Here, we show that a spontaneous loss-of-function mutation in the Tlr4 gene strongly inhibits microglial and monocytic activation by aggregated Alzheimer amyloid peptide resulting in a significantly lower release of the inflammatory products IL-6, TNFalpha and nitric oxide. Treatment of primary murine neuronal cells with supernatant of amyloid peptide-stimulated microglia demonstrates that Tlr4 contributes to amyloid peptide-induced microglial neurotoxicity. In addition, stimulation experiments in transfected HEK293 cells allowed to define a tri-molecular receptor complex consisting of TLR4, MD-2 and CD14 necessary for full cellular activation by aggregated amyloid peptide. A clinical relevance of these findings is supported by a marked upregulation of Tlr4 mRNA in APP transgenic mice and by an increased expression of TLR4 in Alzheimer's disease brain tissue associated with amyloid plaque deposition. Together, these observations provide the first evidence for a role of the key innate immune receptor, TLR4, in neuroinflammation in Alzheimer's disease.
Perbandingan brand equity produk sabun pembersih wajah merek pond’s dengan biore pada mahasiswa fakultas keguruan dan ilmu pendidikan universitas mulawarman samarinda (2017)

This research aim to know the comparison of brand equity between facial wash product brand ponds with biore. Data analysis technique used is different from the mean test with paired samples. Based on the result of the study, it was found that difference between facial wash brand ponds with biore. Of the four indicators that make up the brand equity, ponds is superior to the biore. Additionaly the Biore expected to increase four indicator shaper brand equity in order to become a top brand of facial wash product. Key word: Brand Equity, Brand Awareness,  Brand Association, Perceived Quality, Brand Loyalty.
Reservoir connectivity uncertainty from stochastic seismic inversion (2009)

Static reservoir connectivity analysis is sometimes based on 3D facies or “geobody” models defined by combining well data and inverted seismic impedances. However, this is mostly performed from deterministic inversion results that provide limited information on uncertainty and may yield biased estimates of reservoir volume. Here, we present a workflow exploiting stochastic impedance realisations for facies characterisation and connectivity analysis with uncertainty, and illustrate the workflow using seismic and well data from a turbidite sand reservoir. After pre‐stack stochastic inversion, we perform seismic facies classification based on cross‐plots of inverted elastic attributes, calibrated to log data. Applying the classification to all impedance realisations, we generate multiple seismic sand facies models that can be averaged to produce a sand probability cube, reflecting the level of uncertainty in the inversion process. We then identify all connected sand “geobodies” in each realisation. We rank the facies realisations based on computed geobody statistics. Finally, we combine the geobodies from all realisations to calculate the probability of connection to given wells and the uncertainty in connected sand volume.
Reliability of respiratory tidal volume estimation by means of ambulatory inductive plethysmography (2006)

Ambulatory monitoring of ventilatory parameters in everyday life, field research and clinical situations may offer new insights into respiratory functioning in health and disease. Recent technological advances that employ ambulatory inductive plethysmography could make monitoring of respiration outside the clinic and laboratory feasible. Inductive plethysmography provides a method for nonintrusive assessment of both timing (e.g. respiration rate) and volumetric parameters (e.g. tidal volume and minute ventilation), by which tidal volume is initially calibrated to direct measures of volume. Estimates of tidal volume assessed by this technique have been validated in laboratory investigations, usually examining within-individual relations to direct measures over a large range of tidal volume variation. However, the reliability of individual differences in tidal volume or other breathing parameters has not been tested under naturalistic measurement conditions using inductive plethysmography. We examined the test-retest reliability of respiration rate, tidal volume and other volumetric parameters of breathing over a period of six weeks of repeated measurements during baseline conditions and breathing exercises with 16 healthy freely moving volunteers in a Yoga course. Reliability of measurement was evaluated by calculating the average week-to-week between-subject correlation coefficients for each physiological measure. Additionally because body-mass index has been previously positively correlated to tidal volume, we also assessed this relationship as an external criterion of validity of tidal volume estimation. Regarding the latter, similar correlations to those previous studies were found (r = 0.6). Furthermore, reliability estimates were high and consistent across respiratory measures (typically r's = 0.7-0.8). These results suggest the validity of ambulatory inductive plethysmographic measurement of respiration, at least under relatively sedentary conditions. Findings also point to the stability of individual differences in respiratory parameters over consecutive weeks.
Über eine neue Synthese der Flavon‐carbonsäure‐(8) (1966)

Abstract Die Darstellung der Flavon‐carbonsäure‐(8) durch Oxydation von 8‐Allyl‐ oder 8‐Propenylflavon wird beschrieben.
Ionic liquids and solids with paramagnetic anions (2010)

Four paramagnetic ionic compounds have been prepared and their magnetic, structural and thermal properties have been investigated. The four compounds are methylbutylpyrrolidinium tetrachloroferrate(III) ([Pyrr(14)](+)/[FeCl(4)](-)), methyltributylammonium tetrachloroferrate(III) ([N(1444)](+)/[FeCl(4)](-)), butylmethylimidazolium tetrachloroferrate(III) ([bmim](+)/[FeCl(4)](-)) and tetrabutylammonium bromotrichloroferrate(III) ([N(4444)](+)/[FeBrCl(3)](-)). Temperature-dependent studies of their magnetic behaviors show that all four compounds are paramagnetic at ambient temperatures. Glass transitions are observed for only two of the four compounds, [Pyrr(14)](+)/[FeCl(4)](-) and [bmim](+)/[FeCl(4)](-). Crystal structures for [Pyrr(14)](+)/[FeCl(4)](-) and [N(1444)](+)/[FeCl(4)](-) are compared with the previously reported [N(4444)](+)/[FeBrCl(3)](-).
Two 10Gb/s/pin Low-Power Interconnect Methods for 3D ICs (2007)

Two RF techniques are combined with capacitive coupling interconnect to form ultra-wide-bandwidth impulse interconnect and RF interconnect in 3D IC technology. They achieve 10Gb/s/pin and 11Gb/s/pin transmission with 2.7mW/pin and 4.35mW/pin power consumption, respectively, using the MIT Lincoln Lab 3D 0.18μm CMOS, an 8times improvement over previous work
Isotope ratio measurements of urinary calcium with a thermal ionization probe in a quadrupole mass spectrometer (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsotope ratio measurements of urinary calcium with a thermal ionization probe in a quadrupole mass spectrometerAlfred L. Yergey, Nancy E. Vieira, and James W. HansenCite this: Anal. Chem. 1980, 52, 12, 1811–1814Publication Date (Print):October 1, 1980Publication History Published online1 May 2002Published inissue 1 October 1980https://pubs.acs.org/doi/10.1021/ac50062a008https://doi.org/10.1021/ac50062a008research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The evolving landscape in the therapy of acute myeloid leukemia (2013)

Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of myeloid precursors arrested in their maturation, creating a diverse disease entity with a wide range of responses to historically standard treatment approaches. While significant progress has been made in characterizing and individualizing the disease at diagnosis to optimally inform those affected, progress in treatment to reduce relapse and induce remission has been limited thus far. In addition to a brief summary of the factors that shape prognostication at diagnosis, this review attempts to expand on the current therapies under investigation that have shown promise in treating AML, including hypomethylating agents, gemtuzumab ozogamicin, FLT3 tyrosine kinase inhibitors, antisense oligonucleotides, and other novel therapies, including aurora kinases, mTOR and PI3 kinase inhibitors, PIM kinase inhibitors, HDAC inhibitors, and IDH targeted therapies. With these, and undoubtedly many others in the future, it is the hope that by combining more accurate prognostication with more effective therapies, patients will begin to have a different, and more complete, outlook on their disease that allows for safer and more successful treatment strategies.
110-GHz monolithic resonant-tunneling-diode trigger circuit (1991)

The design and fabrication of a novel resonant tunneling diode (RTD) structure to be used in a monolithically integrated trigger circuit are reported. The structure has been designed to have high peak current densities with relatively low resonant voltages. These devices have been monolithically integrated with resistors to build a high-frequency trigger circuit. Experiments demonstrated triggering performance up to 110 GHz with subpicosecond timing jitter.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
N-Substituted salicylamides as selective malaria parasite dihydroorotate dehydrogenase inhibitors (2011)

In our continuing program to develop Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors, a series of N-substituted salicylamides were synthesized and their ability to selectively inhibit PfDHODH was examined. The synthetic program was based on 2-hydroxy-N-(2-phenylethyl)benzamide (1) that weakly inhibits both PfDHODH and human DHODH (hDHODH). Structure activity relationships were examined for developing derivatives. Selective PfDHODH inhibitors with improved potency were obtained by introducing a 2,2-diphenylethyl substitution on the salicylamidic nitrogen. Biological activity of the most potent compounds was confirmed on parasite infected cells in vitro.