gebhart/patrepeval huggingface dataset:
Modeling of backmixing in continuous polymerization of caprolactam in VK column reactors (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModeling of backmixing in continuous polymerization of caprolactam in VK column reactorsAlok Gupta and Kandukuri S. GandhiCite this: Ind. Eng. Chem. Prod. Res. Dev. 1985, 24, 2, 327–333Publication Date (Print):June 1, 1985Publication History Published online1 May 2002Published inissue 1 June 1985https://pubs.acs.org/doi/10.1021/i300018a030https://doi.org/10.1021/i300018a030research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Neurofeedback Training to Enhance Learning and Memory in Patients with Cognitive Impairment (2011)

The brain tumours can make cognitive impairment especially when they involve the limbic system, the frontal or temporal lobes. The aim of the present study was to examine neurofeedback training (NFT) to enhance learning and memory in patients with cognitive impairment. Single case pre- and post-intervention study was adopted. The qEEG WISC-IV and CBCL test was compared pre and post NFT. Patient was given 40 sessions of NFT, 45 min / day, 3 days a week. The training incorporated video feedback to increase the frequency of Beta waves (15-18 Hz) and to decrease theta waves (3-7 Hz) in T3 and F3. Also, SMR training was performed in Cz to decrease the seizure attacks. qEEG showed prominent different in the brain activity. Results indicated decrease in theta and increase in Beta waves. The present study puts forward that NFT should be taken into account to plan for rehabilitation of patients with cognitive impairment for enhancement of performance in the school or university.
Towards collaborative multi-device computing (2018)

Mobile devices (e.g., smartphone, wearable device) are now an essential part of human life as the most effective and convenient communication tools, providing users with rich experience of various services. Besides traditional web-based services, the research community and industry are exploring computation intensive capabilities of mobile devices to seamlessly augment users' cognitive abilities. However, the resource and communication shortages of a single mobile device make it insufficient in providing high quality of experience (QoE), especially in satisfying the real-time and interactive constraints.Recently, considerable research has addressed these problems, and the proposed systems take advantage of collaborative mobile computing which benefits mobile devices in terms of computing capability, battery life, latency, and data usage. In this survey, we pay our attention to collaborative multi-device computation, and discuss the QoE guarantee, user incentives and other challenges that exit in this area. We also study the networking technologies that can be utilized in multi-device collaboration. In the end of the survey, we point out some future research directions in real-time collaborative mobile systems.
Impact of Chemoselective Pressure on Integration Site Patterns of Lentivirally Transduced Human Hematopoietic Stem Cells (2008)

Abstract Hematologic side effects of cancer chemotherapy like myelosuppression are frequently dose-limiting. Lentiviral gene therapy with cytostatic drug resistance gene transfer to human hematopoietic stem cells (CD34+) is a promising approach to overcome this problem. In this context it is of interest if chemotherapy mediated selection has an impact on lentiviral integration site patterns of transduced hematopoietic stem cells (CD34+). Concerning this issue, human CD34+ cells transduced with a lentiviral self-inactivating (SIN) vector encoding MGMTP140K (the O6-BG resistant mutant of O6-methylguanine- DNA methyltransferase) were in vitro treated with the alkylating agent BCNU. For integration site analysis LM-PCR was performed and integration patterns of the treated and untreated CD34+ cells were analyzed and compared with an in silico set of 106 random integrations. We found different integration preferences of the lentiviral vector between either the treated (82 integrations) or the untreated (30 integrations) CD34+ cells and the in silico set: both groups showed chromosomal preferences, a significant bias for integrations in genes (74,4% in the treated, respectively 70% in the untreated to 40% in the in silico group), especially by favouring introns, a random integration distribution regarding transcription start sites (TSS), and most importantly no significant differences concerning the number of integrations in or near cancer genes. Concerning all integration characteristics we could not find significant differences when comparing the untreated with the treated group. In conclusion, the general distribution of lentiviral integrations in either untreated or treated human CD34+ cells showed no distinct differences between both groups but significant differences compared to the in silico integration set. These results suggest that chemoselection of cells lentivirally overexpressing a specific chemoresistence gene might not influence the integration pattern. Therefore chemotherapy pressure seems not to hamper the safety of lentiviral vectors in gene transfer studies.
MRI of Breast Tumor Initiating Cells Using the Extra Domain-B of Fibronectin Targeting Nanoparticles (2014)

The identification of breast tumor initiating cells (BTICs) is important for the diagnosis and therapy of breast cancers. This study was undertaken to evaluate whether the extra domain-B of fibronectin (EDB-FN) could be used as a new biomarker for BTICs and whether EDB-FN targeting superparamagnetic iron oxide nanoparticles (SPIONs) could be used as a magnetic resonance imaging (MRI) contrast agent for BTIC imaging in vitro and in vivo. BTICs (NDY-1) exhibited high EDB-FN expression, whereas non-BTICs (MCF-7, BT-474, SUM-225, MDA-MB-231) did not exhibit EDB-FN expression. Furthermore, Cy3.3-labeled EDB-FN specific peptides (APTEDB) showed preferential binding to the targeted NDY-1 cells. To construct an EDB-FN targeted imaging probe, APTEDB was covalently attached to a thermally cross-linked SPION (TCL-SPION) to yield APTEDB-TCL-SPION. In the in vitro MRI of cell phantoms, selective binding of APTEDB-TCL-SPION to NDY-1 cells was evident, but little binding was observed in MCF-7 cells. After the intravenous injection of APTEDB-TCL-SPION into the NDY-1 mouse tumor xenograft model, a significant decrease in the signal within the tumor was observed in the T2*-weighted images; however, there was only a marginal change in the signal of non-targeting SPIONs such as APTscramble-TCL-SPION or TCL-SPION. Taken together, we report for the first time that EDB-FN was abundantly expressed in BTICs and may therefore be useful as a new biomarker for identifying BTICs. Our study also suggests that APTEDB-TCL-SPION could be used as an MRI contrast agent for BTIC imaging.
Exercise-Induced Activation of NMDA Receptor Promotes Motor Unit Development and Survival in a Type 2 Spinal Muscular Atrophy Model Mouse (2008)

Spinal muscular atrophy (SMA) is an inborn neuromuscular disorder caused by low levels of survival motor neuron protein, and for which no efficient therapy exists. Here, we show that the slower rate of postnatal motor-unit maturation observed in type 2 SMA-like mice is correlated with the motor neuron death. Physical exercise delays motor neuron death and leads to an increase in the postnatal maturation rate of the motor-units. Furthermore, exercise is capable of specifically enhancing the expression of the gene encoding the major activating subunit of the NMDA receptor in motor neurons, namely the NR2A subunit, which is dramatically downregulated in the spinal cord of type 2 SMA-like mice. Accordingly, inhibiting NMDA-receptor activity abolishes the exercise-induced effects on muscle development, motor neuron protection and life span gain. Thus, restoring NMDA-receptor function could be a promising therapeutic approach to SMA treatment.
Pandemic influenza vaccine: characterization of A/California/07/2009 (H1N1) recombinant hemagglutinin protein and insights into H1N1 antigen stability (2012)

We conclude that, similar to the recombinant seasonal influenza vaccine, recombinant A(H1N1)pdm09 vaccine is likely to perform comparably to licensed A(H1N1)pdm09 vaccines and could offer manufacturing advantages.
Permanent disability from hand dermatitis in females sensitive to nickel, chromium and cobalt. (1979)

Among 564 Danes applying for permanent disability pension due to skin diseases, 222 had allergic contact eczema. Psoriasis was the next most common disorder. Nickel allergy was found in 99 cases, of whom 91 were women with hand eczema. In 43 the primary eczema was on the hands, in 38 under costume jewellery, suspenders, ect. Besides nickel the patients were often sensitive to cobalt, rubber and formaldehyde. Within Denmark there were geographical differences, as only few applicants came from the rural areas. Ten were atopics. 63 were chrome sensitive, including 21 women who all had hand eczema. Like the nickel sensitive they often had additional allergies to cobalt, rubber and formaldehyde. In 53% of the nickel sensitive the hand eczema started in occupations with a high nickel exposure. 39% had frequent changes in occupation, often to a new job with occupational nickel contact. As the patients in the present study were all selected on the basis of their poor prognoses, we have tried to establish prognostic criteria through comparison with unselected material from within the same geographical area.
Distribution of serotypes and antimicrobial resistance of Streptococcus pneumoniae strains isolated in Brazil from 1988 to 1992 (1994)

Forty-two serotypes were identified among 288 Streptococcus pneumoniae strains isolated from patients living in Brazil. Serotyping was determined by the capsular typing test (Quellung reaction). Types 14 (10.4%), 6B (9.8%), 23F (8.0%), 5 (7.3%), 19F (6.9%), 6A (6.0%), and 1 and 4 (4.6%) were the most commonly identified strains. Two hundred twenty (76.4%) of the strains were of serotypes that are included in the 23-valent pneumococcal polysaccharide vaccine. If vaccine-related serotypes are also considered, the proportions of coverage in the vaccine are 82.3% (if type 6B alone is added) and 85.7% (if all the vaccine-related types are considered to be cross-protecting). Decreased susceptibility to penicillin, which was identified by using the 1-microgram oxacillin disk method as a screening test, was detected in 70 (26.7%) strains. The MICs of nine antimicrobial agents were determined by using the procedures recommended by the National Committee for Clinical Laboratory Standards. Seventy (35.9%) of the strains were resistant to tetracycline, 57 (29.2%) were resistant to sulfamethoxazole-trimethoprim, 3 (1.5%) were resistant to rifampin, 2 (0.80%) were resistant to penicillin, and 1 (0.5%) was resistant to chloramphenicol. The two penicillin-resistant strains were also resistant to or had decreased susceptibilities to cephalosporins. Forty-seven (17.9%) of the strains were intermediately resistant to penicillin, 17 (8.7%) were intermediately resistant to tetracycline, 13 (6.7%) were intermediately resistant to chloramphenicol, 12 (6.1%) were intermediately resistant to erythromycin, and 6 (3.1%) were intermediately resistant to rifampin.
Graph-based Attack Detection in Cloud using KDD CUP 99 Dataset (2014)

In the area of research and development effort for cloud computing, Cloud security is considered as one of challenging issues. Most commonly faced attacks are Distributed Denial-of-Service (DDoS) attacks. DDoS attacks are variation of DOS attack at distributed and large-scale level. Firstly attacker tries to discover the vulnerabilities or we can say loopholes of a cloud system and takes control over the virtual machines. And then gets success in deploying DDoS at large scale. Such attacks includes certain actions at initial stage such as exploitation in multiple steps, scanning for uncommon or less occurring vulnerabilities, identified vulnerabilities are utilized against virtual machines to use them as zombies and finally DDOS is achieved through these compromised zombies. To avoid vulnerable virtual machines from being compromised in the cloud system, proposed approach uses multiphase vulnerability detection at distributed level, measurement, countermeasure selection mechanism called as NICE, which is based on attack graph based models and reconfigurable virtual network based countermeasures. Use of standard dataset KDD Cup 99 dataset helps to cover most of the types of intrusion signatures and features. There is a need of processing encrypted traffic also together with plain traffic flowing through the cloud system. As included in the proposed system, host-based intrusion detection system implementation gives more benefits as compare to NIDS based implementation.
Diamond Turning of Optics: The Past, the Present, and the Exciting Future (1978)

Diamond turning of optics has grown from obscurity to popularity. After giving a brief background of the diamond-turning accomplishments, we summarize the technical capabilities and availabilities. Infrared systems applications are the major current production diamond-turning requirements. We discuss ongoing R&D work which bridges the present to the future. The DoD planned manufacturing technology program of the Army, Navy, and ongoing work of the Air Force are discussed briefly.
Charged Ultrafiltration Membranes Increase the Selectivity of Whey Protein Separations (2009)

Ultrafiltration is widely used to concentrate proteins, but fractionation of one protein from another is much less common. This study examined the use of positively charged membranes to increase the selectivity of ultrafiltration and allow the fractionation of proteins from cheese whey. By adding a positive charge to ultrafiltration membranes, and adjusting the solution pH, it was possible to permeate proteins having little or no charge, such as glycomacropeptide, and retain proteins having a positive charge. Placing a charge on the membrane increased the selectivity by over 600% compared to using an uncharged membrane. The data were fit using the stagnant film model that relates the observed sieving coefficient to membrane parameters such as the flux, mass transfer coefficient, and membrane Peclet number. The model was a useful tool for data analysis and for the scale up of membrane separations for whey protein fractionation.
Construction of a Functional Single-Chain Variable Fragment Antibody against Hemagglutinin from<i>Porphyromonas gingivalis</i> (1998)

Hemagglutinin is a major glycoprotein of Porphyromonas gingivalis vesicles and likely confers the ability to adsorb and penetrate into host tissue cells. To protect this bacterial invasion, murine monoclonal antibody (MAb) Pg-vc, which inhibited the hemagglutinating activity, was prepared by using P. gingivalis vesicles as an antigen. Western blot analysis revealed that when both MAb Pg-vc and anti-HA-Ag2 antibody raised against the P. gingivalis hemagglutinin adhesin (M. Deslauriers and C. Mouton, Infect. Immun. 60:2791-2799, 1992) were allowed to react with protein blots from P. gingivalis vesicles, a superimposable profile was observed. To obtain a recombinant antibody, cDNAs coding for the variable domains of the L and H chains of MAb Pg-vc were cloned by PCR, and a plasmid specifying a single-chain variable fragment (ScFv) was constructed. Following transformation of Escherichia coli cells, a recombinant ScFv protein was successfully expressed. The immunological properties of this protein were identical to those of the parental murine MAb, specifically recognizing the two proteins (43 and 49 kDa) originating from P. gingivalis vesicles. In addition, the ScFv antibody inhibited the P. gingivalis vesicle-associated hemagglutinating activity. The amino acid sequences deduced from nucleotide sequencing experiments confirmed that variable heavy-chain and variable light-chain regions belonged to VH1 and Vkappa12/13 families, respectively. Since the expression system used in this study can readily provide large quantities of single-chain recombinant antibody, it may be a useful in developing a therapeutic agent for passive immunization in humans.
Coevolutionary search among adversaries (1997)

Competitive coevolution is a biologically-inspired search technique that uses a genetic algorithm in two competing populations. During search, individuals in each population are evaluated by direct competition against members of the opposing population. A class of adversarial problems is defined, to which competitive coevolution can be applied. In such problems, it is important to actively choose difficult test cases to accurately evaluate candidate solutions. Competitive coevolution evaluates candidate solutions and test cases against one another while searching for both, so that each drives the improvement of the other.
Tools from computational learning theory are used to obtain positive theoretical results on the efficiency of simplified coevolutionary algorithms. Lower bounds show the importance of several parameters for describing performance of these algorithms. This work gives insight into necessary and sufficient conditions for successful coevolutionary search.
Experimental work uses competitive coevolution as a heuristic method for adversarial problems. Several measurement techniques are used to understand the behavior of coevolution. These allow identification of several flaws in simple forms of coevolution. Coevolution can be stalled by the loss of important niches, by coevolutionary cycles, or by a lack of balance between populations. New methods are described that overcome these Aaws and make coevolution more efficient. Competitive fitness sharing preserves important niches, the hall of fame encourages long-term progress, the phantom parasite maintains balance, and shared sampling allows efficient fitness testing. With these new methods, coevolution is able to solve several game learning test problems that cannot be efficiently solved without them.
Several applications are discussed. The first uses a simulation of patient blood pressure during surgery to evaluate drug delivery controllers against patients; the goal is a controller that successfully controls all possible patients. The second application uses a sorting network design problem to explore the relationship between theoretical concepts of testability and experimental coevolutionary behavior. The third application is the design of strategies for the game of Go. Coevolution produces competitive players that push the strategy representation to its limits. Finally, preliminary work is presented on the design of drugs that are robust across possible drug resistance mutations.
OS MANUAIS ESCOLARES DE HERMANTINA RICCIOPPO: resgates da produção de conhecimento geográfico escolar no Triângulo Mineiro, em meados do século XX (2014)

A partir da analise de dois manuais escolares produzidos por uma professora do ensino primario, este trabalho elucida elementos historicos da disciplina escolar de Geografia e suas particularidades no ensino em meados do seculo XX, no municipio de Uberaba, no Triângulo Mineiro, Estado de Minas Gerais, bem como a contextualizacao historico-cultural e as influencias pedagogicas que nortearam a elaboracao da obra. Estes manuais tiveram sua primeira publicacao em 1962 e foram produzidos pela professora Hermantina Riccioppo, sendo destinados ao ensino primario e envolvendo Geografia, Historia e Ciencias Naturais. Acreditamos que o contexto de formacao profissional, de influencia pedagogica, de pesquisa, de dificuldades e ao mesmo tempo de incentivos institucionais, de uma realidade sociopolitica e de desenvolvimento do trabalho escolar com os alunos no Grupo Escolar Minas Gerais se constituiram como um arranjo cultural que se materializou nos manuais escolares. Palavras-chave Manuais escolares, Professora/autora, Historia da disciplina geografia, Triângulo Mineiro. LOS MANUALES ESCOLARES DE HERMANTINA RICCIOPPO: resgates de la produccion de conocimiento geografico escolar en el Triângulo Mineiro, Minas Gerais, Brasil, a mediados del siglo XX Resumen Desde el analisis de dos libros de texto producidos por una maestra de escuela primaria, este trabajo aclara elementos historicos de la disciplina escolar de Geografia y sus peculiaridades en la ensenanza a mediados del siglo XX, en Uberaba, en el Triângulo Mineiro, Minas Gerais, asi como el contexto historico y cultural y las influencias pedagogicas que guiaron el desarrollo de la obra. Estos manuales se publicaron por primera vez en 1962 y fueron producidos por la maestra Hermantina Riccioppo, siendo asignado a la educacion primaria y la ensenanza de Geografia, Historia y Ciencias Naturales. Creemos que el contexto de la formacion profesional, la influencia pedagogica, la investigacion, y las dificultades mientras que los incentivos institucionales, la realidad socio-politica y el desarrollo del trabajo escolar con los estudiantes en el Grupo Escolar Minas Gerais se constituyo como una conjuncion cultural que se ha materializado en libros de texto. Palabras clave Manuales escolares, Maestra/autora, Historia de la disciplina geografia, Triângulo Mineiro. ISSN: 2236-3904 REVISTA BRASILEIRA DE EDUCACAO EM GEOGRAFIA - RBEG www.revistaedugeo.com.br - revistaedugeo@revistaedugeo.com.br
Synthesis of condensed tannins. Part 17. Oligomeric (2R,3S)-3,3′,4′,7,8-pentahydroxyflavans: atropisomerism and conformation of biphenyl and m-terphenyl analogues from Prosopis glandulosa(‘mesquite’) (1986)

(2R,3S)-2,3-trans-3′,4′,7,8-Tetrahydroxyflavan-3-ol [(+)-mesquitol], the predominant metabolite in the heartwood of Prosopis glandulosa, represents a putative precursor of a variety of oligomers, including conventional [4,6]- and [4,8]-biflavan-3-ols, a [1,6]-1,3-diarylpropylflavan-3-ol, [5,6]- and atropisomeric [5,8]-biphenyl-type biflavan-3-ols, and [5,6:5,8]-m-terphenyl-type triflavan-3-ols. Other participants in these condensations are mainly (+)-catechin, and also the flavan-3,4-diol analogue of (+)-mesquitol. Oligomeric structures were confirmed by biomimetic oxidative and acid-induced couplings, and by nuclear Overhauser effect difference spectroscopy. These applications enabled correction of previous structural assignments for atropisomeric [5,8]-(+)-mesquitol-(+)-catechins and [5,6:5,8]-bis-[(+)mesquitol]-(+)-catechins, and determination of their conformations.