gebhart/patrepeval huggingface dataset:
Cdk1-Cyclin B1-mediated Phosphorylation of Tumor-associated Microtubule-associated Protein/Cytoskeleton-associated Protein 2 in Mitosis (2009)

During mitosis, establishment of structurally and functionally sound bipolar spindles is necessary for maintaining the fidelity of chromosome segregation. Tumor-associated microtubule-associated protein (TMAP), also known as cytoskeleton-associated protein 2 (CKAP2), is a mitotic spindle-associated protein whose level is frequently up-regulated in various malignancies. Previous reports have suggested that TMAP is a potential regulator of mitotic spindle assembly and dynamics and that it is required for chromosome segregation to occur properly. So far, there have been no reports on how its mitosis-related functions are regulated. Here, we report that TMAP is hyper-phosphorylated at the C terminus specifically during mitosis. At least four different residues (Thr-578, Thr-596, Thr-622, and Ser-627) were responsible for the mitosis-specific phosphorylation of TMAP. Among these, Thr-622 was specifically phosphorylated by Cdk1-cyclin B1 both in vitro and in vivo. Interestingly, compared with the wild type, a phosphorylation-deficient mutant form of TMAP, in which Thr-622 had been replaced with an alanine (T622A), induced a significant increase in the frequency of metaphase cells with abnormal bipolar spindles, which often displayed disorganized, asymmetrical, or narrow and elongated morphologies. Formation of these abnormal bipolar spindles subsequently resulted in misalignment of metaphase chromosomes and ultimately caused a delay in the entry into anaphase. Moreover, such defects resulting from the T622A mutation were associated with a decrease in the rate of protein turnover at spindle microtubules. These findings suggest that Cdk1-cyclin B1-mediated phosphorylation of TMAP is important for and contributes to proper regulation of microtubule dynamics and establishment of functional bipolar spindles during mitosis.
Chemical method for achieving acceleration of macroparticles to ultrahigh velocities. Annual report. Progress report No. 1, 1 June 1985-28 February 1986 (1986)

The authors have been exploring the critical aspects of this program largely as outlined in the statement of work of their original proposal. Their main concentration has been on the velocity range between 6 and 50 km/sec. Recent investigations have proved very encouraging in that they have revealed a way in which they can use conventional gaseous explosives such as oxygen and hydrogen properly diluted to achieve velocities up to 11 km/sec. A discussion of this promising technique is contained in Appendix A. This has been an important finding in that it allows the use of a more comfortable entrance velocity to the beginning of the technique of the solid explosive driven ramjet. This would avoid the complication of sensitizing a relatively low detonation velocity solid explosive and constitutes, the authors feel, a significant advance in their theoretical development. As stated in the original proposal, calculations up to the 25 km/sec range necessitated the adoption of simplifications in order to develop an overall physical picture of the process. The authors fully realize that, before proposing any serious experiments, a much more complete set of calculations of the 11 to 50 km/sec possibilities must be developed. Therefore, they have initiated themore » process of developing the computational fluid mechanics codes necessary to carry out the detailed calculations necessary to either uncover hidden difficulties or unexpected advantages. These computational fluid dynamics calculations have been initiated, using recent advances in computational fluid mechanics principles. Work on the axisymmetric nonsteady flow codes is currently under way and it appears that there do not exist any unusual computational barriers to prevent obtaining the required depth of understanding for this program. Current progress in this program and plans for the future are reported in Appendix B.« less
A Sec-Dependent Secretory Protein of the Huanglongbing-Associated Pathogen Suppresses Hypersensitive Cell Death in Nicotiana benthamiana (2020)

"<i>Candidatus</i> Liberibacter asiaticus" (CLas) is a phloem-restricted Gram-negative bacterium that is the causal agent of citrus huanglongbing (HLB). In this study, we identified a CLas-encoded Sec-dependent secretory protein CLIBASIA_04405 that could contribute to the pathogenicity of this bacterium. The gene expression level of CLIBASIA_04405 was significantly higher in citrus than in psyllids. Transient overexpression of the mature CLIBASIA_04405 protein (m4405) in <i>Nicotiana benthamiana</i> leaves could suppress hypersensitive response (HR)-based cell death and H<sub>2</sub>O<sub>2</sub> accumulation triggered by the mouse BAX and the <i>Phytophthora infestans</i> INF1. An alanine-substitution mutagenesis assay revealed the essential of amino acid clusters EKR<sup>45-47</sup> and DE<sup>64-65</sup> in cell death suppression. Challenge inoculation of the transgenic <i>N. benthamiana</i>-expressing m4405 with <i>Pseudomonas syringae</i> DC3000Δ<i>hopQ1-1</i> demonstrated the greatly reduced bacterial proliferation. Remarkably, transcriptome profiling and RT-qPCR analysis disclosed that the gene expression of six small heat shock proteins (sHSPs), a set of plant defense regulators, were significantly elevated in the transgenic m4405 lines compared with those in wild-type <i>N. benthamiana</i>. In addition, the transgenic m4405 lines displayed phenotypes of dwarfism and leaf deformation. Altogether, these data indicated that m4405 was a virulence factor of CLas.
KNOXVILLE FACILITY TACKLES SOLID WASTE (1998)

For thirty years, the mantra of the waste management field has been Reuse, Reduce, Recycle. With the opening of its new $2.5-million facility on Earth Day 1997, the city of Knoxville, Tennessee has not only Talked the Talk, but has also Walked the Walk of the three Rs. Through careful and thoughtful planning and design, the city has reused and recycled an existing site into one of the premier waste management facilities in the state.
Multiple Future Prediction Leveraging Synthetic Trajectories (2021)

Trajectory prediction is an important task, especially in autonomous driving. The ability to forecast the position of other moving agents can yield to an effective planning, ensuring safety for the autonomous vehicle as well for the observed entities. In this work we propose a data driven approach based on Markov Chains to generate synthetic trajectories, which are useful for training a multiple future trajectory predictor. The advantages are twofold: on the one hand synthetic samples can be used to augment existing datasets and train more effective predictors; on the other hand, it allows to generate samples with multiple ground truths, corresponding to diverse equally likely outcomes of the observed trajectory. We define a trajectory prediction model and a loss that explicitly address the multimodality of the problem and we show that combining synthetic and real data leads to prediction improvements, obtaining state of the art results.
Nutritional, socioeconomic, and reproductive factors in relation to female breast cancer mortality: findings from a cross-national study. (1996)

Using data from 66 countries, we conducted an international comparison study to identify the most important predictors of female breast cancer mortality rates. This study was unique in that it included data on per capita tobacco disappearance, alcohol consumption, socioeconomic status (SES), reproductive factors, and a wide array of nutritional data. Results of correlation and single independent-variable linear regression models indicated that breast cancer mortality was most strongly associated with dietary factors typically associated with affluence, especially animal products. The strongest negative (i.e., protective) associations were with those variables related to increased fertility and population growth. A multiple linear regression that accounted for all important predictors simultaneously explained 91% of the variability in mortality rates across these countries. This model indicated a strong positive association between breast cancer mortality and calories from animal sources. Fish and cereal products as well as annual percentage growth in population appeared to exert protective effects. Despite the limitations of this type of analysis, the observed effect of high meat and animal product consumption, the major contributor to variability in dietary fat, as well as the protective effect of increased fertility are consistent with the known biology of breast cancer. The protective effect of fish and cereal consumption that we observed will require further study.
New codes and inner bounds for exact repair in distributed storage systems (2014)

We study the exact-repair tradeoff between storage and repair bandwidth in distributed storage systems (DSS). We give new inner bounds for the tradeoff region and provide code constructions that achieve these bounds.
Rhenium-Catalyzed Epoxide Deoxygenation: Scope and Limitations (2003)

Transfer of oxygen atoms from epoxides to triphenyl­phosphine is efficiently catalyzed by Tp′ReO3 [Tp′ = hydrido-tris-(3,5-dimethylpyrazolyl)borate] in benzene at 75-105 ºC. The reaction tolerates a wide variety of functional groups including ketones (conjugated or non-conjugated to the new double bond), esters, nitriles, ethers, silyl ethers and phthalimides. Relative rates vary with substitution pattern and electronics; in general, monosub­stituted and 2,2-disubstituted epoxides react fastest, and cis-2,3-di­substituted systems react faster than trans. Electron-withdrawing substituents promote the reaction.
Competition between particle formation and burrowing: Gold on bismuth (2008)

We discuss Au vapor deposition on polycrystalline Bi under conditions where particle formation and burrowing are competitive. Burrowing occurs because the surface free energy of Bi is lower than that of Au, the Au-Bi interface energy is small, and the kinetics, in terms of high surface and grain boundary diffusion rates, are favorable. For formation of Au particles on Bi, kinetic Monte Carlo simulations that include the relative rates of atom impingement, surface diffusion, and burrowing show a broadening of the overall size distribution. This occurs because burrowing continuously removes small particles from the surface, reduces the density of existing nuclei, and allows those that remain to grow by atom capture to larger sizes before they too are completely burrowed. These results are important for systems where nanostructures are assembled on low surface energy substrates.
Chugai Pharmaceuticals Co., Ltd (2003)

Pharmaceutical strategic business consultancy involved in partnering, licensing, acquisitions, divestments and new business start-ups. We assist in due diligence and write expert reports for investors. We are experts in business intelligence and markets
Barium intravasation during an upper gastrointestinal examination: a case report and literature review. (1995)

Barium ingestion is a routine practice in the radiologic examination of the alimentary tract. Barium intravasation is a rare complication, often resulting in the rapid onset of hypotension and death. The literature on this type of complication is sparse. In the majority of reported cases, the event involved high pressure barium instillation. This case illustrates the rare occurrence of barium in the portal venous circulation after an upper gastrointestinal examination.
Bioassay and biochemical analyses of insecticide resistance in southern African <i>Anopheles funestus</i> (Diptera: Culicidae) (2001)

Anopheles funestus Giles has been implicated as a major malaria vector in sub-Saharan Africa where pyrethroid insecticides are widely used in agriculture and public health. Samples of this species from northern Kwazulu/Natal in South Africa and the Beluluane region of southern Mozambique showed evidence of resistance to pyrethroid insecticides. Insecticide exposure, synergist and biochemical assays conducted on A. funestus suggested that elevated levels of mixed function oxidases were responsible for the detoxification of pyrethroids in resistant mosquitoes in these areas. The data suggested that this mechanism was also conferring cross-resistance to the carbamate insecticide propoxur.
Surface strontium enrichment on highly active perovskites for oxygen electrocatalysis in solid oxide fuel cells (2012)

Perovskite oxides have high catalytic activities for oxygen electrocatalysis competitive to platinum at elevated temperatures. However, little is known about the oxide surface chemistry that influences the activity near ambient oxygen partial pressures, which hampers the design of highly active catalysts for many clean-energy technologies such as solid oxide fuel cells. Using in situsynchrotron-based, ambient pressure X-ray photoelectron spectroscopy to study the surface chemistry changes, we show that the coverage of surface secondary phases on a (001)-oriented La0.8Sr0.2CoO3−δ (LSC) film becomes smaller than that on an LSC powder pellet at elevated temperatures. In addition, strontium (Sr) in the perovskite structure enriches towards the film surface in contrast to the pellet having no detectable changes with increasing temperature. We propose that the ability to reduce surface secondary phases and develop Sr-enriched perovskite surfaces of the LSC film contributes to its enhanced activity for O2 electrocatalysis relative to LSC powder-based electrodes.
Feature Selection and Stacking for Robust Discrimination of Speech, Monophonic Singing, and Polyphonic Music (2005)

In this work we strive to find an optimal set of acoustic features for the discrimination of speech, monophonic singing, and polyphonic music to robustly segment acoustic media streams for annotation and interaction purposes. Furthermore we introduce ensemble-based classification approaches within this task. From a basis of 276 attributes we select the most efficient set by SVM SFFS. Additionally relevance of single features by calculation of information gain ratio is presented. As a basis of comparison we reduce dimensionality by PCA. We show extensive analysis of different classifiers within the named task. Among these are Kernel Machines, Decision Trees, and Bayesian Classifiers. Moreover we improve single classifier performance by Bagging and Boosting, and finally combine strengths of classifiers by StackingC. The database is formed by 2,114 samples of speech, and singing of 58 persons. 1,000 Music clips have been taken from the MTV-Europe-Top-20 1980-2000. The outstanding discrimination results of a working real time capable implementation stress the practicability of the proposed novel ideas.
Comparison of deterministic wavelet estimation and statistic wavelet estimation through predictive deconvolution on the quality of well tie - application on synthetic and real data (2016)

Well to seismic tie is used to correlate well log information to the seismic data.The main link between a primary reflection signal and the reflectivity from a well log is the seismic wavelet.In this paper we test two different methods to estimate the seismic wavelet for the well tie procedure: one based on both the well log and seismic data, the deterministic approach, and one based only on the real seismic trace, through the predictive deconvolution.Our tests with numerical data show the estimation of seismic wavelet with reasonable accuracy for both cases.The feasibility of this approach is also verified on a real seismic and well data from Viking Graben field, North Sea, Norway.
A Self-Alignment System for LOS Optical Wireless Communication Links (2017)

This letter presents a self-alignment system using a continuous and a proportional-to-position-error correction algorithm. The system is designed to address uninterrupted point-to-point high-speed line-of-sight optical wireless links. The alignment correction employs amplitude detection from a mm2scale CMOS-compatible 4-PD array connected to a 4-channel receiver and followed by digital-processing and feedback toward the receiver lens position. The proposed self-alignment method is validated with a receiver position varying over about 5-cm range and a receiver angle covering around ±10 degree with roughly ×4 field-of-view widening due to the automatic alignment. A 50-Mb/s ON-OFF-keying transmission link is maintained across 4 meters distance using a 650-nm-red light-emitting-diode source with a bit-error-rate below the forward-error-correction limit of 3.8 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> .
Case-based reasoning support for online catalog sales (1998)

Case-based reasoning uses similarity measures and domain-specific knowledge for information retrieval and problem solving. The paper considers how CBR techniques can be applied to e-commerce applications to enable intelligent sales support. It reviews the limitations of ordinary databases to this task and then examines CBR techniques that can improve the usefulness of electronic catalogs. It describes an implementation of a CBR-based system in a specific application domain, and concludes with brief descriptions of two projects at the University of Kaiserslautern that advance these systems.
Construction and use of a bifunctional streptomycete cosmid (1984)

Conference Article| August 01 1984 Construction and use of a bifunctional streptomycete cosmid ANNE E. CHAMBERS; ANNE E. CHAMBERS * 1Pfizer Ltd., Sandwich, Kent CT13 9NJ, U.K. Search for other works by this author on: This Site PubMed Google Scholar IAIN S. HUNTER IAIN S. HUNTER † 2Pfizer Ltd., Sandwich, Kent CT13 9NJ, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1984 Biochemical Society1984 Biochem Soc Trans (1984) 12 (4): 644–645. https://doi.org/10.1042/bst0120644 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation ANNE E. CHAMBERS, IAIN S. HUNTER; Construction and use of a bifunctional streptomycete cosmid. Biochem Soc Trans 1 August 1984; 12 (4): 644–645. doi: https://doi.org/10.1042/bst0120644 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: kb, kilobase This content is only available as a PDF. © 1984 Biochemical Society1984 Article PDF first page preview Close Modal You do not currently have access to this content.
Gold—Chlorine and Gold—Bromine Equilibria in Fused Salts (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGold—Chlorine and Gold—Bromine Equilibria in Fused SaltsDenis D. Durnan, Alan D. Mighell, Edward J. Zapolski, and Reuben E. WoodCite this: J. Phys. Chem. 1964, 68, 4, 847–850Publication Date (Print):April 1, 1964Publication History Published online1 May 2002Published inissue 1 April 1964https://pubs.acs.org/doi/10.1021/j100786a024https://doi.org/10.1021/j100786a024research-articleACS PublicationsRequest reuse permissionsArticle Views39Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
HIV ENV Glycoprotein-mediated Bystander Apoptosis Depends on Expression of the CCR5 Co-receptor at the Cell Surface and ENV Fusogenic Activity (2011)

HIV-1 infections lead to a progressive depletion of CD4 cells culminating in AIDS. The coreceptor usage by HIV varies from CCR5 (R5) tropic early in infection to CXCR4 (X4) tropic in later infections. Although the coreceptor switch from R5 to X4 tropic HIV is well associated with progression to AIDS, the role of CCR5 in disease progression especially in patients infected exclusively with R5 isolates throughout the disease remains enigmatic. To better understand the role of CCR5 and R5 tropic HIV envelope in AIDS pathogenesis, we asked whether the levels of CCR5 and/or HIV Env-mediated fusion determine apoptosis of bystander cells. We generated CD4(+) T cell lines expressing varying levels of CCR5 on the cell surface to show that CCR5 expression levels correlate with bystander apoptosis induction. The mechanism of apoptosis involved caspase-3 activation and mitochondrial depolarization and was dependent on gp41 fusion activity as confirmed by fusion-restricted gp41 point mutants and use of the fusion inhibitor T20. Interestingly, lower levels of CCR5 were able to support virus replication in the absence of bystander apoptosis. Our findings suggest that R5 HIV-1-mediated bystander apoptosis is dependent on both CCR5 expression levels as well as fusogenic activity of the Env glycoprotein.
Adaptive data transmission based on band-selection for MC-CDMA systems (2002)

We introduce an adaptive band-selection (ABS) scheme for Multi Carrier-Code Division Multiple Access (MC-CDMA) systems to improve system capacity. Instead of using all subcarriers, mobile stations transmit message data only through the selected frequency bands based on band-selection coefficients from the base station. By using the adaptive band-selection scheme, ABS MC-CDMA systems accommodate more users than MC-CDMA systems that use all frequency bands for message data transmission. Due to the time-varying wireless channel conditions and dynamic power allocations, band-selection coefficients should be adaptively determined at the base station every update period. In our ABS MC-CDMA systems, the processing gain, the transmitted power and the data rate depend on the number of selected bands. Under the assumption that the total transmission power and the total amount of transmission data are the same for both MC-CDMA systems and ABS MC-CDMA systems, SNR behaviors are investigated and BER performances are presented in terms of the number of users and the normalized Doppler frequencies.
Molecular Mechanisms of Epigenetic Variation in Plants (2012)

Natural variation is defined as the phenotypic variation caused by spontaneous mutations. In general, mutations are associated with changes of nucleotide sequence, and many mutations in genes that can cause changes in plant development have been identified. Epigenetic change, which does not involve alteration to the nucleotide sequence, can also cause changes in gene activity by changing the structure of chromatin through DNA methylation or histone modifications. Now there is evidence based on induced or spontaneous mutants that epigenetic changes can cause altering plant phenotypes. Epigenetic changes have occurred frequently in plants, and some are heritable or metastable causing variation in epigenetic status within or between species. Therefore, heritable epigenetic variation as well as genetic variation has the potential to drive natural variation.