gebhart/patrepeval huggingface dataset:
The Carboxy-Terminal Neh3 Domain of Nrf2 Is Required for Transcriptional Activation (2005)

Nrf2 is a transcription factor critical for the maintenance of cellular redox homeostasis. We have previously found that Nrf2 is a labile protein, and its activation in cells under stress involves mechanisms leading to its stabilization. As a modular protein, Nrf2 possesses distinct transactivation and DNA binding domains essential for its transcriptional activity. In this study, we found that the C-terminal "Neh3" domain of Nrf2 is also important for its activity. Deletion of the last 16 amino acids of the protein completely abolishes its ability to activate both reporter and endogenous gene expression. Using site-directed mutagenesis, we have identified a stretch of amino acids within this region that are essential for its activity and that are found to be conserved across species and among other members of the CNC-bZIP family. Importantly, deletion of the final 16 amino acids of Nrf2 does not influence its dimerizing capability, DNA binding activity, or subcellular localization, although it does increase the half-life of the protein. In addition, this region was found to be important for interaction with CHD6 (a chromo-ATPase/helicase DNA binding protein) in a yeast two-hybrid screen. RNA interference-mediated knockdown of CHD6 reduced both the basal and tert-butylhydroquinone-inducible expression of NQO1, a prototypical Nrf2 target gene. These data suggest that the Neh3 domain may act as a transactivation domain and that it is possibly involved in interaction with components of the transcriptional apparatus to affect its transcriptional activity.
The pharmacology of 20681-S and 20682-S, 6-oxo-N-cyclopropylmethylmorphinans, as narcotic antagonist analgesics. (1979)

It has been demonstrated that L-3hydroxy-6-oxo-N-cyclopropylmethylmorphinan methansulfonate (20681-S) and L-3,14-dihydroxy-6-oxo-N-cyclopropylmethylmorphinan methansulfonate (20682-S), have antinociceptive and narcotic antagonistic properties. In the rodent antinociceptive test, the action of 20681-S was more potent and of longer duration than that of morphine and of cyclazocine after subcutaneous or oral administration. The antinociceptive effect of 20682-S ranked between that of morphine and that of pentazocine in the mouse acetic acid-writhing test. Both compounds possessed potent narcotic antagonistic activities, 20682-S being more active than naloxone and oxilorphan and 20681-S being equipotent with cyclazocine. The latent side effects (respiratory depression and fall in blood pressure) and the acute toxicity of 20681-S and 20682-S, were less than those of reference narcotic antagonists or of narcotic antagonist analgesics.
<i>Borrelia burgdorferi ospC</i> Heterogeneity among Human and Murine Isolates from a Defined Region of Northern Maryland and Southern Pennsylvania: Lack of Correlation with Invasive and Noninvasive Genotypes (2005)

B. burgdorferi invasiveness correlates with ospC genotype. To test this hypothesis and whether identical genotypes infect humans and small mammals in specific sites, B. burgdorferi ospC heterogeneity was tested among isolates from northern Maryland and southern Pennsylvania. Six culture-positive patients allowed collection of small animals from their properties, and spirochetes from animals trapped within 300 yards of each patient's home were isolated. 3' ospC sequences were compared to reference sequences. Of the 7 human and 15 mouse DNA templates that produced reliable sequences, all clustered with references into only four and seven distinct clades, respectively. A human and a mouse isolate with the same ospC were seen in only one locality, and five of six sites contained two or more B. burgdorferi ospC clones. Four invasive patient isolates and six small mammal isolates clustered with "noninvasive" reference ospC genotypes. A high degree of ospC diversity exists among B. burgdorferi isolates in Maryland and Pennsylvania, even in narrowly defined geographic localities. Dissemination in mice and humans by noninvasive ospC types contradicts the ospC invasiveness hypothesis. Alternative genetic markers for B. burgdorferi disseminated disease should be investigated.
SERS Labels for Red Laser Excitation: Silica‐Encapsulated SAMs on Tunable Gold/Silver Nanoshells (2009)

In a glass house: Silica-encapsulated self-assembled monolayers (SAMs) on tunable gold/silver nanoshells were used as labels for surface-enhanced Raman scattering (SERS). This concept combines the spectroscopic advantages arising from maximum surface coverage and uniform molecular orientation of the Raman reporter molecules within the complete monolayer together with the high chemical and mechanical stability of the glass shell.
CFC alternatives fail to take off in Europe (1993)

Huge differences are emerging in U.S. and European demand for chlorofluorocarbon (CFC) alternatives. European refrigeration system makers have made virtually no progress in replacing ozone-depleting CFCs with alternatives, according to ICI Klea (Runcorn, U.K.) - the newly named CFC-alternatives business of ICI (London). Meanwhile, U.S. tax incentives are spurring demand for CFC alternatives. Under European Community regulation, production and consumption of CFCs should be 50% lower as of Jan. 1, 1993, compared with the base year of 1986, and 85% lower by Jan. 1, 1994. CFC producers say the first target has been reached, but virtually all the reduction has been achieved through cuts in aerosol use.
Challenges of migrating to agile methodologies (2005)

Software development methodologies are constantly evolving due to changing technologies and new demands from users. Today's dynamic business environment has given rise to emergent organizations that continuously adapt their structures, strategies, and policies to suit the new environment [12]. Such organizations need information systems that constantly evolve to meet their changing requirements---but the traditional, plan-driven software development methodologies lack the flexibility to dynamically adjust the development process.
1. Introduction: Framing the View: Russian Women in the Long Nineteenth Century (2012)

Thinking of nineteenth-century Russia, we may find ourselves thinking of a woman’s image, perhaps one of the memorable heroines in the great Russian novels written by men: Sonia Marmeladova from Dostoevskii’s Crime and Punishment (Prestuplenie i nakazanie), Natasha Rostova from Tolstoi’s War and Peace (Voina i mir), or any of the Turgenev heroines so exemplary that a special adjective was created for the type. These characters have deeply influenced our perceptions of Russian life, to the poi...
Improving amplify-and-forward relay selection algorithm based on partial relay link (2010)

这篇文章处理在 amplify-and-forward (AF ) 选择一个适当继电器的设计问题合作差异系统。在这方面，这篇文章仅仅越过来源和继电器连接基于部分隧道知识集中于继电器选择。特别地，二个基本问题将被回答，也就是说是否合作并且与谁一起合作。通过回答这二个问题，改进继电器选择策略基于部分继电器连接，强调合作必要时发生，被建议瞄准最大化平均相互的信息。以力量分配和继电器选择，然后，联合优化被采用基于部分继电器连接为继电器选择保证柔韧的表演。最佳力量在来源和选择继电器之间被分配在目的地最大化产量 signal-to-noise (SNR ) 。模拟结果生产改进计划能比以前的工作和柔韧的表演完成更好的性能，这能被采用联合优化保证。
A RED discard strategy for ATM networks and its performance evaluation with TCP/IP traffic (1999)

In ATM UBR networks supporting TCP traffic, optimal efficiency can only be envisaged if switches adopt a discard mechanism that operates at the packet level rather than the cell level. In this paper, we define a variant of the RED discard strategy suitable for ATM switches. An interesting feature of this ATM-RED is that it has a similar per-VC implementation complexity as the Early Packet Discard (EPD) algorithm. To study the efficiency of the ATM-RED discard strategy, we compare its performance with plain the UBR, EPD and Fair Buffer Acceptance (FBA) discard strategies by means of simulation with TCP/IP traffic. We give comparative results with respect to different performance criteria such as goodput and fairness in various environments, such as end-to-end ATM networks and IP-based networks with an ATM backbone, in both single-bottlenecked and GFC topologies.
Use of Serum Immune Complexes in a New Test That Accurately Confirms Early Lyme Disease and Active Infection with <i>Borrelia burgdorferi</i> (2001)

The present recommendation for serologic confirmation of Lyme disease (LD) calls for immunoblotting in support of positive or equivocal ELISA. Borrelia burgdorferi releases large quantities of proteins, suggesting that specific antibodies in serum might be trapped in immune complexes (ICs), rendering the antibodies undetectable by standard assays using unmodified serum. Production of ICs requires ongoing antigen production, so persistence of IC might be a marker of ongoing or persisting infection. We developed an immunoglobulin M (IgM) capture assay (EMIBA) measuring IC-derived IgM antibodies and tested it using three well-defined LD populations (from an academic LD referral center, a well-described Centers for Disease Control and Prevention (CDC) serum bank, and a group of erythema migrans patients from whose skin lesions B. burgdorferi was grown) and controls (non-Lyme arthritis inflammatory joint disease, syphilis, multiple sclerosis, and nondisease subjects from a region where LD is endemic, perhaps the most relevant comparison group of all). Previous studies demonstrated that specific antigen-antibody complexes in the sera of patients with LD could be precipitated by polyethylene glycol and could then be disrupted with maintenance of the immunoreactivity of the released antibodies, that specific anti-B. burgdorferi IgM was concentrated in ICs, and that occasionally IgM to specific B. burgdorferi antigens was found in the IC but not in unprocessed serum. EMIBA compared favorably with commercial and CDC flagellin-enhanced enzyme-linked immunosorbent assays and other assays in confirming the diagnosis of LD. EMIBA confirmed early B. burgdorferi infection more accurately than the comparator assays. In addition, EMIBA more accurately differentiated seropositivity in patients with active ongoing infection from seroreactivity persisting long after clinically successful antibiotic therapy; i.e., EMIBA identified seroreactivity indicating a clinical circumstance requiring antibiotic therapy. Thus, EMIBA is a promising new assay for accurate serologic confirmation of early and/or active LD.
A Five-fingered Underactuated Prosthetic Hand System (2006)

A five-fingered underactuated prosthetic hand controlled by surface EMG (electromyographic) signals is presented in this paper. The prosthetic hand is designed with simplicity, lightweight and dexterity on the requirement of anthropomorphic hands. Underactuated self-adaptive theory is adopted to decrease the number of motors and weight. The fingers of the hand with multi phalanges have the same size as an adult hand. The prosthetic hand control part is based on an EMG motion pattern classifier which combines VLR (variable learning rate) based neural network with wavelet transform and sample entropy. This motion pattern classifier can successfully identify the flexion and extension of the thumb, the index finger and the middle finger, by measuring the EMG signals through three electrodes mounted on the flexor digitorum profundus, flexor pollicis longus and extensor digitorum. Furthermore, via continuously controlling single finger's motion, the five-fingered underactuated prosthetic hand can achieve more prehensile postures such as power grasp. The experimental results show that the system has a great application value
Osteochondral allografts in arm and forearm surgery. (1991)

Osteochondral allografting can restore the skeletal continuity anatomically after a limb salvage procedure. Evaluation of the clinical function indicates that a good result can be anticipated. Fracture was the most frequent complication, and the fixation technique we used initially predisposed the problem. The major advantage of allograft is the possibility of reinsertion of soft tissue to help stabilize the new joint. In addition, any part of the limb can potentially be reconstructed with an allograft.
Inner myometrial laceration causing a massive postpartum hemorrhage: a case report. (2006)

Inner myometrial lacerations must be considered in the differential diagnosis of postpartum hemorrhage when all other commonly established causes have been excluded. During laparotomy and hysterotomy, evaluation and repair of an inner myometrial laceration controls the bleeding and avoids a hysterectomy.
Theoretical model and error analysis of acoustic correlation current profiler (ACCP) (2003)

Acoustic correlation current profiler (ACCP) is suitable for long range current profiling. Based on the ocean acoustic reverberation theory, the authors constructed the theoretical model of ACCP and obtained the spatial correlation function of the ACCP sonar array and its minimal velocity estimate variance. Maximum likelihood estimate is adopted to process the ACCP signal. The coded signal, whose autocorrelation has peaks at time lag 0 and /spl tau/, was transmitted. This special transmission signal cuts down the processing complexity greatly and reduces signal overlapping. The estimate variance and its relationship with SNR and range are given. All these results are very useful for designing ACCP with good performance.
The analgesic action of some flavonoids in the hot plate test. (1979)

Albino-Swiss male mice were tested in the hot plate test. Oligomeric procyjanidin (OL-1), rutin, quercetin, hyperoside and vitexin rhamnoside were administered intraperitoneally in doses 3.5 and 10 mg/kg. It was found that OL-1, rutin and hyperoside but not vitexin rhamnoside exert analgesic action, whereas quercetin even decreases the pain threshold level. The mechanism of the analgesic action of flavonoids remains to be explained.
Analysis of fluorescence lifetime data for single Rhodamine molecules in flowing sample streams (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalysis of fluorescence lifetime data for single Rhodamine molecules in flowing sample streamsJoel. Tellinghuisen, Peter M. Goodwin, W. Patrick. Ambrose, John C. Martin, and Richard A. KellerCite this: Anal. Chem. 1994, 66, 1, 64–72Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ac00073a013https://doi.org/10.1021/ac00073a013research-articleACS PublicationsRequest reuse permissionsArticle Views539Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Microdischarge in microbridge plasma display with holes in the cathode (1998)

A new microbridge plasma display structure with holes in the cathode has been fabricated and operated at high gas pressure (400-700 Torr). With a hole diameter of 100 μm, the slope of the I-V curve in the discharge cell of the new structure is positive at 700 Torr. It is found that the discharge in this new structure has about 100 kohm internal resistance, and the discharges are stable when operated without current limiting resistors. The operating current in the new structure is about 50 μA with smaller 75 μm diameter holes in the cathode.
Identification and molecular characterization of an efflux system involved in Pseudomonas putida S12 multidrug resistance (2001)

The authors previously described srpABC, an operon involved in proton-dependent solvent efflux in the solvent-tolerant Pseudomonas putida S12. Recently, it was shown that organic solvents and not antibiotics induce this operon. In the present study, the authors characterize a new efflux pump, designated ArpABC, on the basis of two isolated chloramphenicol-sensitive transposon mutants. The arpABC operon is involved in the active efflux of multiple antibiotics, such as tetracycline, chloramphenicol, carbenicillin, streptomycin, erythromycin and novobiocin. The deduced amino acid sequences encoded by the three genes involved show a striking resemblance to proteins of the resistance/nodulation/cell division family, which are involved in both organic solvent and multiple drug efflux. These findings demonstrate that ArpABC is highly homologous to the MepABC and TtgABC efflux systems for organic solvents and multiple antibiotics. However, ArpABC does not contribute to organic solvent tolerance in P. putida S12 but is solely involved in multidrug resistance.
Synthesis and biological evaluation of a 4-fluoromethyl monobactam analog. (1983)

The synthesis and in vitro antibacterial activity of (+/-)(cis)-3-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]- 4-fluoromethyl-2-oxo-1-azetidinesulfonic acid, potassium salt are presented.
Open Hole Horizontal Well Cleanup in Sand Control Completions: State of the Art in Field Practice and Laboratory Development (1998)

This paper was prepared for presentation at the 1998 European Petroleum Conference held in The Hague, The Netherlands, 20-22 October 1998.
Design of a highly magnified directional acoustic source based on the resonant cavity of two-dimensional phononic crystals (2006)

The authors report a design of a highly magnified directional acoustic source based on the planar resonant cavity of two-dimensional phononic crystals. The authors demonstrate that the order of the resonant mode and the reflective ratio of the double phononic crystal slab are the key factors to the magnified ratio of the directional acoustic amplifier. With properly designed mode and cavity width of the asymmetric phononic structure, the optimal magnified amplitude can be achieved by more than 86.5 times in comparison with the amplitude of the original line source freely radiating in water.
The Preparation and Properties of [Re(amine)<sub>4</sub>O<sub>2</sub>]<sup>+</sup> Type Ions (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation and Properties of [Re(amine)4O2]+ Type IonsJohn H. Beard, Judith Casey, and R. Kent MurmannCite this: Inorg. Chem. 1965, 4, 6, 797–803Publication Date (Print):June 1, 1965Publication History Published online1 May 2002Published inissue 1 June 1965https://pubs.acs.org/doi/10.1021/ic50028a006https://doi.org/10.1021/ic50028a006research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Accelerated wound healing in mice by local administration of sustained-release CpG oligodeoxynucleotide (136.4) (2010)

Abstract Recent reports show that wounds in mice lacking MyD88 heal at a delayed rate, suggesting that the innate immune pathway can affect the healing process. Preliminary studies revealed that the kinetics of wound healing in TLR9 KO mice were also delayed when compared to congenic controls, suggesting that this activation pathway may contribute physiologically to wound healing. Synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs mimic the ability of bacterial DNA to stimulate an innate immune response via TLR9. We incorporated CpG ODN into a vehicle (basement membrane extract) that slowly released bioactive ODN to wound sites. The effect of the ODN was then examined using a murine excisional skin biopsy model. Results show that CpG ODN treatment significantly accelerates wound repair in normal adult and aged mice (p &lt; 0.0001 and p &lt; 0.01, respectively). Consistent with these effects being mediated by CpG signaling via TLR9, no effect was observed in TLR9 KO mice. Histologic studies indicate that CpG treatment promotes local accumulation of macrophages, increases production of VEGF, and accelerates neovascularization, resulting in accelerated granulation and wound closure in wildtype (but not TLR9 KO mice, p &lt; 0.01). Current findings suggest that immunostimulatory oligonucleotides may represent a novel, inexpensive, safe and effective means of improving wound repair.
THE RENEWAL OF ROD AND CONE OUTER SEGMENTS IN THE RHESUS MONKEY (1971)

The renewal of retinal rod and cone outer segments has been studied by radioautography in rhesus monkeys examined 2 and 4 days after injection of leucine-(3)H. The cell outer segment consists of a stack of photosensitive, membranous discs. In both rods and cones some of the newly formed (radioactive) protein became distributed throughout the outer segment. Furthermore, in rods (but not in cones), there was a transverse band of concentrated radioactive protein slightly above the outer segment base 2 days after injection. This was due to the formation of new discs, into which labeled protein had been incorporated. At 4 days, these radioactive discs were located farther from the outer segment base. Repeated assembly of new discs had displaced them away from the basal assembly site and along the outer segment. Measurements of the displacement rate indicated that each retinal rod produces 80-90 discs per day, and that the entire complement of outer segment discs is replaced every 9-13 days. To compensate for the continual formation of new discs, groups of old discs are intermittently shed from the apical end of the cell and phagocytized by the pigment epithelium. Each pigment epithelial cell engulfs and destroys about 2000-4000 rod outer segment discs daily. The similarity between visual cells in the rhesus monkey and those in man suggests that the same renewal processes occur in the human retina.