gebhart/patrepeval huggingface dataset:
RODERICK PEATTIE, GEOGRAPHER AND ROMANTICIST, 1891–1955 (1957)

(1957). RODERICK PEATTIE, GEOGRAPHER AND ROMANTICIST, 1891–1955. Annals of the Association of American Geographers: Vol. 47, No. 1, pp. 97-99.
Rapamycin Resistance Is Linked to Defective Regulation of Skp2 (2012)

The mammalian target of rapamycin (mTOR) plays a role in controlling malignant cellular growth. mTOR inhibitors, including rapamycin (sirolimus), are currently being evaluated in cancer trials. However, a significant number of tumors are rapamycin resistant. In this study, we report that the ability of rapamycin to downregulate Skp2, a subunit of the ubiquitin protein ligase complex, identifies tumors that are sensitive to rapamycin. RNA interference (RNAi)-mediated silencing of Skp2 in human tumor cells increased their sensitivity to rapamycin in vitro and inhibited the growth of tumor xenografts in vivo. Our findings suggest that Skp2 levels are a key determinant of antitumor responses to mTOR inhibitors, highlighting a potentially important pharmacogenomic marker to predict sensitivity to rapamycin as well as Skp2 silencing strategies for therapeutic purposes.
Traditions, Entrepreneurship, And Creative Governance: A Comparative Case Study of Cultural and Creative Industry and City’s Transformation in Macau and Tallinn (2014)

Cultural and creative industry is important drive for the economy, especially in economic crisis and cities’ transformation, which have proven by some great cities like London, New York, Brussels, Toronto and etc. Thus, some governments of the world adopted these concepts to transform their cities expectantly by cultural and creative strategies or city plans, it has heightening the hot spot of cultural and creative industry in public, incubating creative entrepreneurs, and accordingly gradually changing the cities’ traditions where the culture and creative industry stemmed from. This paper selects two cities which are in transforming state with active governance to cultural and creative industry. They are Macau and Tallinn located in Asia and Europe respectively. This research explores the interactive effects of tradition, entrepreneurship, creative governance on evolving cultural and creative industry and transforming city. The paper adopts qualitative and quantitative methods together to collect the data such as governmental statistics analysis, participant observing, in-depth interviewing of different groups, and finally comparatively analyzed the first-hand data with constructive grounded theory. This paper focuses on the four major results. First, entrepreneurship of the city is the key drive for evolving culture and creative industry and transforming a city; second, the pattern of creative governance influences cultivating entrepreneurship for cultural and creative industry; Third, more importantly, transforming the city is closely related to the ability and model of the creative governance imposing on changing the traditions of the city;finally, cultural and creative industry is conducive to build creative milieu in specific area of the city and gradually change the dependence on traditional development path of the city.
A UHPLC-MS/SRM method for analysis of phenolics from Camellia sinensis leaves from Nilgiri hills (2016)

Analysis of phenolics differentiates the top three leaves (Ist, IInd and IIIrd) in tea plants from Nilgiri hills.
Titration of individual components in a mixture with resolution of difference spectra, pKs, and redox transitions (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTitration of individual components in a mixture with resolution of difference spectra, pKs, and redox transitionsRichard I. Shrager and Richard W. HendlerCite this: Anal. Chem. 1982, 54, 7, 1147–1152Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/ac00244a031https://doi.org/10.1021/ac00244a031research-articleACS PublicationsRequest reuse permissionsArticle Views411Altmetric-Citations133LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Metabolic defense of the body weight set-point. (1984)

The energy needs of an organism are a function of the tissue mass it maintains. Interspecific comparisons indicate that energy needs are a power function of body weight (12). Much of the work described here represents an effort to ascertain whether the function relating intraspecific energy expenditure to maintained body weight takes a similar form. The evidence to date from various rat preparations suggests that although some differences may exist, the form of the function for rats is not likely to differ substantially from the interspecific function derived by Kleiber (12). What has also emerged from this work, however is evidence that both the inter- and intraspecific functions accurately predict energy needs only when the organism is at the particular body weight it normally maintains and defends. This is because a rise in weight from the normal level causes energy needs to increase at a faster rate than the relationship would predict, whereas declines in weight from this level produce greater than predicted decreases in energy expenditure. We thus propose that an animal's body weight set-point be taken as the weight at which its daily energy needs can be accurately predicted from its metabolic body size. It is only at this one body weight that the animal is normometabolic. It can then be asked whether organisms maintaining abnormally high or low body weights are suffering from regulatory dysfunctions or regulating normally but at elevated or depressed set-points. We have seen that obese Zucker rats display the same adaptive metabolic adjustments to weight loss as normal weight rats. Since the exact form of the intraspecific body weight-metabolic needs relationship has not yet been determined, we must withhold judgment as to whether Zucker fatty rats are normometabolic at their elevated body weights. Since they display an effective metabolic defense of their obesity, however, an elevated set-point, rather than regulatory failure, seems to be the more probable cause of the Zucker fatty's condition. More compelling evidence of regulation at an altered body weight set-point is provided by the LH-lesioned rat. This preparation is normometabolic at the reduced body weight it maintains, and it becomes hypermetabolic when its weight is elevated to the level of nonlesioned littermates. The obesity of the VMH-lesioned rat, on the other hand, may well stem from primary regulatory impairments.(ABSTRACT TRUNCATED AT 400 WORDS)
ChemInform Abstract: CATALYTIC ASYMMETRIC HYDROSILYLATION OF OLEFINS. III. CHIRAL PHOSPHINE‐PALLADIUM(II) COMPLEXES AS HYDROSILYLATION CATALYSTS (1981)

Abstract Die in situ dargestellten Palladiumkomplexe (III) katalysieren die asymmetrische Hydrosilylierung des Styrols (IV) bzw. der cyclischen Diene (VII), (IX) und (X) zu den optisch aktiven Produkten 1‐Phenyl‐ethyl‐trichlorsilan (VI) bzw. zu den 2‐Cycloalkenyl‐trichlorsilanen (VIII) bzw. (XI).
3′‐end processing of precursor M1 RNA by the N‐terminal half of RNase E (2002)

M1 RNA, the catalytic component of Escherichia coli RNase P, is derived from the 3'-end processing of precursor M1 RNA, a major transcript of the rnpB gene. In this study, we investigated the mechanism of 3'-end processing of M1 RNA using the recombinant N-terminal half RNase E. The cleavage site preference of RNase E differed from that of the 40% ammonium sulfate precipitate (ASP-40), a partially purified cell extract containing processing activity. However, the addition of a trace amount of ASP-40 changed the cleavage site preference of RNase E to that of ASP-40 suggesting the involvement of a soluble factor in cleavage site preference.
Aviation, traînées de condensation et climat (1999)

Dédiée aux sciences de l'atmosphère, au climat et à d'autres domaines connexes, tels que l'océanographie ou la glaciologie, La Météorologie, révisée par des pairs et publiée en français, s'adresse aux professionnels de la météo et du climat, aux enseignants, aux étudiants, aux amateurs et aux utilisateurs. La Météorologie a succédé en 1925 à l'Annuaire de la Société météorologique de France (1852-1924) qui avait lui-même succédé à l'Annuaire météorologique de la France (1849-1851).
An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. (2003)

Scutellaria lateriflora is an herbal medicine with long-standing traditional use as a relaxing nervine. There has been controversy in the literature with regards to its efficacy, and this study was designed to clarify its effectiveness in reducing anxiety, one of the phytotherapeutic indications. A double blind, placebo-controlled study of healthy subjects demonstrated noteworthy anxiolytic effects. The use of phytomedicines for the treatment of anxiety is reviewed, as is the published literature on S. lateriflora and its putative toxicity.
Abrupt Buckling Transition Observed during the Plectoneme Formation of Individual DNA Molecules (2008)

The response of single DNA molecules to externally applied forces and torques was directly measured using an angular optical trap. Upon overwinding, DNA buckled abruptly as revealed by a sharp extension drop followed by a torque plateau. When the DNA was held at the buckling transition, its extension hopped rapidly between two distinct states. Furthermore, the initial plectonemic loop absorbed approximately twice as much extension as was absorbed into the plectoneme upon each additional turn. The observed extension change after buckling and the postbuckling torque support a recent DNA elasticity model.
Adaptive sampling frequency for sampled-data control systems (1962)

Sampled-data control systems generally have fixed sampling frequencies which must be set high enough to give satisfactory performance for all anticipated conditions. A study is made here of an adaptive system which varies the sampling frequency by measuring a system parameter. It is shown that a sampler followed by a zero-order hold whose sampling period is controlled by the absolute value of the first derivative of the error signal will be a more "efficient" sampler than a fixed-frequency sampler. That is, over a given time interval, fewer samples are needed with the variable-frequency system than with a fixed-frequency system while maintaining essentially the same response characteristics. Analog computer studies of simple Type I and Type II sampled-data servo systems with error sampling and unity feedback verified the method. Standard analog computer components were used to set up a simulated servo system, a rate detector, absolute-value detector, a voltage-controlled oscillator, and a sampler and zero-order hold. The system described reduced the number of samples required for response to a step input to about three-quarters that required in a fixed-sampling-frequency system. Over a long period of time savings in the number of samples required can be expected to be between 25 and 50 per cent. In many applications the savings produced by reducing the over-all number of samples required may outweigh the added complexity of the adaptive-sampling-frequency system.
Seismic attribute selection and clustering to detect and classify surface waves in multicomponent seismic data by using <i>k</i> -means algorithm (2017)

Seismic records are characterized by a high level of complexity resulting from the interaction of different types of waves propagating in the subsurface. Interpretation of the different wave modes and features present in a seismic record generally is done by expert judgment, and its automatization is a problem that has not been resolved completely. We present a methodology that uses pattern recognition to select the best seismic attributes that should be chosen to detect and classify surface waves in a seismic record, based on the notion of similarity, and that is applied on the automatic interpretation of three different seismic-data record sets. The classification obtained for these different real data sets exhibits well-differentiated zones that improve and automatize the expert judgment interpretation.
Interaction of ibuprofen with the H-2 receptor antagonists ranitidine and cimetidine (1985)

The influences of cimetidine and ranitidine on single-dose ibuprofen kinetics were evaluated. Thirteen healthy subjects took a single, 600 mg oral dose of ibuprofen on three occasions: in the control state without drug coadministration; during concurrent dosing with cimetidine, 1.2 gm/day; and during concurrent dosing with ranitidine, 150 mg twice daily. Compared with the control state, cimetidine increased the peak serum ibuprofen concentration (64 vs. 56 micrograms/ml), but the value during ranitidine dosing (57 micrograms/ml) was indistinguishable from the control value. There were no significant differences between control, cimetidine, and ranitidine conditions in ibuprofen elimination t1/2 (2.1, 2.1, and 2.0 hours, respectively). Overall there was a significant difference among the control, cimetidine, and ranitidine conditions in ibuprofen oral clearance (52.8, 48.3, and 54.1 ml/min, respectively), but individual differences in cimetidine vs. control and between ranitidine vs. control were not statistically significant. The impairment of ibuprofen clearance by cimetidine is small, and ranitidine had no detectable effect on ibuprofen kinetics. These findings should be further validated during chronic dosing with ibuprofen.
Das Rechnungswesen der Kreditinstitute (1987)

Das BANKHAUS SCHROEDER ist eine Privatbank, die sowohl im Privatkunden- als auch im Firmenkundenbereich tätig ist.
Long-term intake of Lactobacillus paracasei KW3110 prevents age-related chronic inflammation and retinal cell loss in physiologically aged mice (2018)

Age-related chronic inflammation is a major risk factor for the incidence and prevalence of age-related diseases, including infectious and neurodegenerative diseases. We previously reported that a lactic acid bacteria, <i>Lactobacillus paracasei</i> KW3110, activated macrophages and suppressed inflammation in mice and humans. In this study, we investigated whether long-term intake of heat-killed L. paracasei KW3110 modulated age-related inflammation and altered the gut microbiota in physiologically aged mice. Compared with age-matched control mice, fecal analyses of gut microbiota revealed that intake of <i>L. paracasei</i> KW3110 mitigated age-related changes of beneficial bacterial composition, including the <i>Bifidobacteriaceae</i> family. <i>L. paracasei</i> KW3110 intake also mitigated age-related immune defects by reducing the prevalence of interferon-gamma (IFN-γ) -producing inflammatory CD4-positive T cells in the lamina propia of the small intestine, and reduced serum levels of proinflammatory cytokines. Furthermore, <i>L. paracasei</i> KW3110 intake suppressed retinal inflammation by reducing proinflammatory cytokine-producing macrophage, and age-related retinal cell loss. Taken together, these findings suggested that <i>L. paracasei</i> KW3110 mitigated age-related chronic inflammation through modulation of gut microbiota composition and immune system functions in aged mice, and also reduced age-related retinal ganglion cell (RGC) loss. Further studies are needed to evaluate the effect in age-related senescent changes of the retina.
Small‐interfering <scp>RNA</scp>s (<scp>siRNA</scp>s) as a promising tool for ocular therapy (2013)

RNA interference (RNAi) can be used to inhibit the expression of specific genes in vitro and in vivo, thereby providing an extremely useful tool for investigating gene function. Progress in the understanding of RNAi-based mechanisms has opened up new perspectives in therapeutics for the treatment of several diseases including ocular disorders. The eye is currently considered a good target for RNAi therapy mainly because it is a confined compartment and, therefore, enables local delivery of small-interfering RNAs (siRNAs) by topical instillation or direct injection. However, delivery strategies that protect the siRNAs from degradation and are suitable for long-term treatment would be help to improve the efficacy of RNAi-based therapies for ocular pathologies. siRNAs targeting critical molecules involved in the pathogenesis of glaucoma, retinitis pigmentosa and neovascular eye diseases (age-related macular degeneration, diabetic retinopathy and corneal neovascularization) have been tested in experimental animal models, and clinical trials have been conducted with some of them. This review provides an update on the progress of RNAi in ocular therapeutics, discussing the advantages and drawbacks of RNAi-based therapeutics compared to previous treatments.
Fabrication of poly(methyl methacrylate) microfluidic chips by redox‐initiated polymerization (2007)

In this report, a method based on the redox-initiated polymerization of methyl methacrylate (MMA) has been developed for the rapid fabrication of poly(methyl methacrylate) (PMMA) microfluidic chips. MMA containing 2-2'-azo-bis-isobutyronitrile was allowed to prepolymerize in a water bath to form a viscous prepolymer solution that was subsequently mixed with MMA containing a redox-initiation couple of benzoyl peroxide/N,N-dimethylaniline. The dense molding solution was sandwiched between a silicon template and a piece of 1-mm-thick PMMA plate. The polymerization could complete within 50 min under ambient temperature. The images of raised microfluidic structures on the silicon template were precisely replicated into the synthesized PMMA substrate during the redox-initiated polymerization of the molding solution. The chips were subsequently assembled by the thermal bonding of the channel plates and the covers. The new fabrication approach obviates the need for special equipment and significantly simplifies the process of fabricating PMMA microdevices. The attractive performance of the novel PMMA microchips has been demonstrated in connection with contactless conductivity detection for the separation and detection of ionic species.
Isokibdelones:  Novel Heterocyclic Polyketides from a <i>Kibdelosporangium</i> sp. (2006)

[Structure: see text] The isokibdelones are an unprecedented family of polyketides produced by an Australian isolate of a rare actinomycete, Kibdelosporangium sp. The structures of the isokibdelones were assigned by spectroscopic analysis and chemical interconversion. A proposed biosynthesis requires a novel molecular twist that generates an unprecedented heterocyclic system and differentiates the isokibdelones from their kibdelone co-metabolites. SAR analysis on the isokibdelones further defines the anticancer pharmacophore of these novel polyketides.
Chemical and Immunological Assay of the Nonreducing Terminal Residues of Chondroitin Sulfate from Human Aggrecan (1997)

Samples of aggrecan chondroitin sulfate, isolated from normal human knee cartilages of individuals from fetal to 72 years of age, were digested with chondroitin lyases. The products were analyzed by fluorescence-based anion exchange high performance liquid chromatography to separate and quantitate nonreducing terminal structures, in addition to internal unsaturated disaccharide products. The predominant terminal structures were the monosaccharides, GalNAc4S and GalNAc4,6S as they were present on 85-90% of all chains. The remaining chains terminated with the disaccharides GlcAbeta1,3GalNAc4S and GlcAbeta1,3GalNAc6S. Marked changes in the relative abundance of these terminals were identified in the transition from growth cartilage to adult articular cartilage. First, terminal GalNAc residues were almost exclusively 4-sulfated in aggrecan from fetal through 15 years of age, but were approximately 50% 4,6-disulfated in aggrecans from adults (22-72 years of age). Second, the terminal disaccharide GlcAbeta1,3GalNAc4S was on approximately 7% of chains on aggrecan from fetal through 15 years of age, but on only approximately 3% of chains on adult aggrecan. In contrast, the proportion of chains terminating in GlcAbeta1,3GalNAc6S, approximately 9%, was unchanged from fetal to 72 years of age. This terminal disaccharide is proposed to be recognized by the widely used monoclonal antibody 3B3. However, chemical quantitation of the structure together with solid phase 3B3(-) immunoassay of fetal and adult aggrecans showed that the content of the terminal disaccharide does not necessarily correlate with immunoreactivity of the proteoglycan, as chain density and presentation on the solid phase are critical factors for recognition of chain terminals by 3B3. The quantitative results obtained from chemical analyses of all nonreducing termini of aggrecan chondroitin sulfate chains revealed important changes in chain termination that occur when cellular activities are altered as adult articular cartilage is formed after removal of growth cartilage. These findings are discussed in relation to specific enzymatic steps that generate the nonreducing termini of chains in the biosynthesis pathway of chondroitin sulfate proteoglycans and their modulation in tissue development and pathology.
Dynamic Analysis and CFD Numerical Simulation on Backpressure Filling System (2015)

A backpressure filling system is a kind of air type filling system which could be applied to power type, fine or coarse grain, or mixtures with fine and coarse components. The working principle of backpressure filling system was discussed based on fundamental hydromechanics. The research limit values of backpressure were achieved via mechanical analysis. Comparing with the exit velocity of material by theoretical analysis and numerical simulation, the CFD simulation model was confirmed and its related parameters were determined. The CFD numerical simulation shows the relationship between production capacity of packaging machine and backpressure, and the results matched actual operation of the equipment well. Combining with the demand of device capacity, the range of backpressure could be controlled at 8 kPa~11 kPa.
The Research of Identity Management Services and its Key Devices for Mobile Internet (2012)

This paper presents an eID based solution to use for mobile internet, namely a platform structure and some key devices to realize the solution, in order to bring us an approach more secure and convenience to access online banking services and avoids some privacy leaking and online banking fishing problems.
Molecular genetics of too much bone (2002)

Bone remodelling is an important process both throughout growth and in adult life. The homeostasis of bone tissue is maintained by the balanced processes of bone resorption and formation. Imbalance can give rise to a broad spectrum of skeletal pathologies, of which osteoporosis, characterized by a decrease in bone density leading to increased fracture risk, is the best known because of its high prevalence and consequently high socio-economic impact. At the opposite end of the spectrum, several genetic conditions displaying too much bone are situated. Mainly because of their monogenic nature-in contrast to the multifactorial character of osteoporosis-the underlying molecular genetic causes for several of these conditions have been revealed recently. In this review, the most important gene identifications of the last years and their impact on the understanding of bone biology are discussed.