gebhart/patrepeval huggingface dataset:
Oral Administration of Growth Hormone (GH) Releasing Peptide-Mimetic MK-677 Stimulates the GH/Insulin-Like Growth Factor-I Axis in Selected GH-Deficient Adults<sup>1</sup> (1997)

To determine the effect of the GH releasing peptide (GHRP)-mimetic, MK-677, on the GH/insulin-like growth factor-I (IGF-I) axis in selected GH-deficient adults, we studied nine severely GH-deficient men [peak serum GH concentration in response to insulin-induced hypoglycemia of 1.2 +/- 1.5 micrograms/L, mean +/- SD (range 0.02-4.79)], age 17-34 yr, height 168 +/- 1.5 cm, body mass index 22.6 +/- 3.3 kg/m2, who had been treated for GH deficiency with GH during childhood. In a double-blind rising-dose design, subjects received once daily oral doses of 10 or 50 mg MK-677 or placebo for 4 days over two treatment periods separated by at least 28 days. Four subjects received placebo and 10 mg/day MK-677 in a cross-over fashion in periods 1 and 2. Five subjects received 10 mg and then 50 mg/day MK-677 in a sequential, rising-dose fashion in periods 1 and 2, respectively. Blood was collected every 20 min for 24 h before treatment and at the end of each period for GH measurement using an ultrasensitive assay. The drug was generally well tolerated, with no significant changes from baseline in circulating concentrations of cortisol, PRL, and thyroid hormones. Serum IGF-i and 24-H mean GH concentrations increased in all subjects after treatment with both 10 and 50 mg/day MK-677 vs. baseline. After treatment with 10 mg MK-677, IGF-I concentrations increased 52 +/- 20% (65 +/- 6 to 99 +/- 9 micrograms/L, geometric mean +/- intrasubject SE, P < or = 0.05 vs. baseline), and 24 h mean GH concentrations increased 79 +/- 19% (0.14 +/- 0.01 to 0.26 +/- 0.02 microgram/L, P < or = 0.05 vs. baseline). Following treatment with 50 mg MK-677, IGF-I concentrations increased 79 +/- 9% (84 +/- 3 to 150 +/- 6 micrograms/L, P < or = 0.05 vs. baseline) and 24-h mean GH concentrations increased 82 +/- 29% (0.21 +/- 0.02 to 0.39 +/- 0.04 microgram/L, P < or = 0.05 vs. baseline), respectively. Serum IGF binding protein-3 concentrations increased with both 10 mg (1.2 +/- 0.1 to 1.7 +/- 0.1 micrograms/L, P < or = 0.05) and 50 mg MK-677 (1.7 +/- 0.1 to 2.2 +/- 0.2 micrograms/L, P < or = 0.05). The GH response to MK-677 was greater in subjects who were the least GH/IGF-I deficient at baseline; by linear regression analysis the increase in 24-h mean GH concentration was positively related to both baseline 24-h mean GH concentration (r = 0.81, P = 0.009) and baseline IGF-I (r = 0.79, P = 0.01) for 10 mg MK-677. IGF-I responses were not significantly related to any baseline measurement. Fasting and postprandial insulin and postprandial glucose increased significantly after MK-677 treatment, and the clinical significance of these changes will need to be assessed in longer term studies. Oral administration of such GHRP-mimetic compounds may have a role in the treatment of GH deficiency of childhood onset.
An Adapted Clinical Measurement Tool for the Key Symptoms of CLN2 Disease (2018)

Neuronal ceroid lipofuscinosis type-2 (CLN2) disease is a rare, autosomal recessive, pediatric-onset, neurodegenerative lysosomal storage disease caused by mutations in the TPP1 gene. Cerliponase alfa (Brineura®), a recombinant form of human tripeptidyl peptidase-1, was recently developed as a treatment for CLN2 disease. In clinical trials, the primary end point to evaluate treatment effect was the aggregate score for the motor and language (ML) domains of the CLN2 Clinical Rating Scale, an adaptation of the Hamburg scale’s component items that include anchor point definitions to allow consistent ratings in multinational, multisite, clinical efficacy studies. Psychometric analyses demonstrated that the ML score of the CLN2 Clinical Rating Scale and individual item scores are well defined and possess adequate measurement properties (reliability, validity, and responsiveness) to demonstrate a clinical benefit over time. Additionally, analyses comparing the CLN2 Clinical Rating Scale ML ratings to the Hamburg scale’s ML ratings demonstrated adequate similarity.
Restricted domains of the sperm surface. (1982)

The plasma membrane of the sperm is a mosaic, with different moieties restricted to specific areas of the head or tail. Some of these heterogeneously distributed surface components are inserted into the membrane during spermatogenesis while others are acquired during post-testicular maturation, as the sperm passes through the epididymis. A variety of surface probes have been used to examine sperm, with lectins and antibodies proving to be effective at relating quantitative and qualitative changes to specific areas of the sperm surface. More recently, monoclonal antibodies have been used in conjunction with surface labeling procedures to study the distribution, time and site of origin and possible roles of sperm components. The use of such highly specific probes in conjunction with high resolution SEM instruments and new molecular labeling techniques offer considerable promise in addressing these problems.
Cytokines and Regulatory T Cells in Rheumatoid Arthritis and Their Relationship with Response to Corticosteroids (2010)

Patients at onset of RA present fewer alterations in cytokine levels and Treg than those with longer disease duration, supporting the role of disease progression in subsequent changes. The antiinflammatory balance observed in high IL-10/low TNF-α patients treated with prednisone supports the use of these genetic polymorphisms as predictors of response to corticosteroid therapy.
A LITERATURE REVIEW FOR ASSESSING THE STATUS OF CURRENT METHODS OF REDUCING DEER-VEHICLE COLLISIONS (1998)

Diverse older adults in an urban setting participating in a longitudinal peer program experienced reduced loneliness, depression, and barriers to socializing. Matching by shared backgrounds facilitated rapport and bonding between participants and peers.
Concrete polymer materials, production methods and applications (1977)

Concrete polymer materials are being used world-wide in applications where high strength and durability are required. Methods for producing two materials, polymer impregnated concrete and polymer concrete, are discussed and their structural and durability properties summarized. Existing and potential applications for these materials such as for chemical storage tanks, pilings, pipe, curbstones, and bridge decks are reviewed.
Experimental Test on the Last Common Ancestor: Reproduction of the Ancient Proteins. (2003)

The results of an experimental test for verifying the hypothesis that the common ancestor of all living organisms (universal ancestor, commonote) was a hyperthermophile (Miyazaki, et al., 2001), are explained. In the experiment, mutant enzymes with ancestral aminoacids were made using a gene engineering technique. The mutant enzymes were purified and tested for thermostability. The mutant enzymes with ancestral aminoacids showed higher thermostability than the contemporary hyperthermophile enzyme. The results suggest that the common ancestor of all living organisms was a hyperthermophile. The argument related to the hyperthermophilic common ancestor hypothesis was reviewed with respect to the experimental test.
1.3-$\mu$m Quantum-Dot Multisection Superluminescent Diodes With Extremely Broad Bandwidth (2007)

A novel ridge-waveguide quantum-dot superluminescent diode is reported. The multisection configuration enables the simultaneous realization of ultrawide 3-dB bandwidth (>150 nm) and an output power greater than 1 mW
Design optimization for asymmetrical half-bridge converters (2002)

A zero-voltage switching (ZVS) technique employing a resonant-transition during a switching interval has been explored for many years. To ensure ZVS operation, two approaches were frequently chosen, separately or mixed. One is to have enough gap on the main core. The other is to add an external inductor in series with the main transformer. However, both approaches suffer from the parasitic ringing phenomena in the practical circuit. The parasitic ringing is generated by the leakage inductance/external inductor and the stray capacitance seen from the transformer primary winding. It introduces additional losses and EMI noise. To alleviate these problems, a ring-free mechanism is proposed. It can apply to most of the conventional zero-voltage switching topologies. The asymmetrical half-bridge converter with this mechanism is presented here. With 94% efficiency and 6 dB improvement on conducted EMI measurement were recorded using an offline 24 V/5 A prototype.
Development of an interactive, real-time, multimedia flow-diagnostics laboratory (1996)

In the Aerospace Engineering Department at Texas A & M University, research advances in fluid mechanics/aerodynamics related hardware and software have recently been completed. These advances include the development of novel experimental flow-diagnostics techniques for low-speed aerodynamics applications and interactive multimedia software for flow-field presentation. We have integrated the newly acquired knowledge and technology into an interactive real-time multimedia experimental flow-diagnostics environment for the undergraduate and graduate teaching applications and laboratory research in fluid mechanics/aerodynamics. In graduate research, this environment is a valuable tool in documenting and modeling complex 3D flows in aerodynamic design and evaluation. In undergraduate and graduate education, it supersedes conventional approaches to lecture-laboratory combining courses in aerodynamics/fluid mechanics. The laboratory applications provide a stimulating interactive environment with a wealth of user-experiment interaction options. The environment, its utilization in graduate research, as well as current efforts for incorporating it into the curriculum of the Aerospace Engineering Department of Texas A & M University are described. (Author)
Augmentable gamma belief networks (2016)

To infer multilayer deep representations of high-dimensional discrete and nonnegative real vectors, we propose an augmentable gamma belief network (GBN) that factorizes each of its hidden layers into the product of a sparse connection weight matrix and the nonnegative real hidden units of the next layer. The GBN's hidden layers are jointly trained with an upward-downward Gibbs sampler that solves each layer with the same subroutine. The gamma-negative binomial process combined with a layer-wise training strategy allows inferring the width of each layer given a fixed budget on the width of the first layer. Example results illustrate interesting relationships between the width of the first layer and the inferred network structure, and demonstrate that the GBN can add more layers to improve its performance in both unsupervisedly extracting features and predicting heldout data. For exploratory data analysis, we extract trees and subnetworks from the learned deep network to visualize how the very specific factors discovered at the first hidden layer and the increasingly more general factors discovered at deeper hidden layers are related to each other, and we generate synthetic data by propagating random variables through the deep network from the top hidden layer back to the bottom data layer.
A New Solution to Lamport's Concurrent Programming Problem Using Small Shared Variables (1983)

A new solution to the concurrent programming control (mutual exclusion) problem that is immune to process failures and restarts is presented. The algorithm uses just four values of shared memory per process, which is within one value of the known lower bound. The algorithm is implemented using two binary variables that make it immune to read errors occurring during writes, that is, "flickering bits."
Cannabis for dyskinesia in Parkinson disease (2004)

Orally administered cannabis extract resulted in no objective or subjective improvement in dyskinesias or parkinsonism.
Effects of dietary oxidized oil and vitamin E on the growth, blood parameters and body composition of juvenile Atlantic cod<i>Gadus morhua</i>(Linnaeus 1758) (2008)

The effects of oxidized dietary lipid and the role of vitamin E on the growth performance, blood parameters and body composition of juvenile Atlantic cod (Gadus morhua) were evaluated over a 9-week feeding period. Four isonitrogenous experimental diets containing fresh or oxidized fish oil with or without added vitamin E (α-tocopherol or mixed tocopherols) were fed to juvenile cod. The oxidized lipid used had a peroxide value of 94 mEq kg−1 oil. No significant (P>0.05) differences in growth performance (weight gain and specific growth rate) or feed utilization (feed consumption and feed efficiency ratio) were observed when oxidized dietary lipid was used. The hepatosomatic index (HSI), viscerosomatic index (VSI) and haematocrit did not show any significant (P>0.05) differences among the treatments. However, erythrocyte osmotic fragility (EOF), referred to as susceptibility to haemolysis, of fish fed oxidized oil without added vitamin E was high in comparison with those fed unoxidized oil. Supplementation with α-tocopherol appeared to decrease haemolysis, but mixed tocopherols had no significant (P>0.05) effect on EOF. The proximate composition of fish whole body was also affected by diet treatment. Fatty acid composition of liver total lipid reflected that of dietary lipid. Variations in tissue (liver and muscle) fatty acid composition among the treatments followed the same trend as those of the dietary fatty acids. Fish fed fresh oil had a higher proportion of polyunsaturated fatty acids (PUFA) in muscle and liver lipid than those fed oxidized oil. The results suggest that oxidized dietary oil affected juvenile Atlantic cod in certain tissues and that these effects could be alleviated by supplementation of sufficient amounts of vitamin E in the diet.
Space-time block coding applied to turbo coded multicarrier CDMA (2004)

In this article, we combine a space-time block code (STBC) with a multi-carrier code division multiple access (MC-CDMA) system and a turbo code (TC) as channel code. MC-CDMA is likely to be one of the most promising access techniques for future wireless communication systems [N. Yee et al. (1993)] [M. Helard et al. (May 2001)]. In fact, MC-CDMA exploits the advantages of both the orthogonal frequency division multiplex (OFDM) multi-carrier modulation and of the code division multiple access (CDMA) technique. Moreover, the use of a multiple input multiple output (MIMO) OFDM system associated with a STBC code allows the achievement of both space and frequency diversities [J.-M. Auffray et al. (September)]. In this paper, we compare several STBC codes such as the Alamouti code [S. M. Alamouti et al. (October 1998)] and the generalized codes for 3 or 4 antennas proposed by Tarokh [ V. Tarokh et al. (July 1999)] applied to a MC-CDMA system leading to different spectral efficiencies. Then, since turbo coded MC-CDMA was demonstrated to be very efficient for a single input single output (SISO) system, allowing the use of a simple single user (SU) detector [M. Helard et al. (May 2001)], we extend this system to multiple input multiple output (MIMO) systems for different STBC. Simulation results are provided for full load systems.
The Alkaline Hydrolysis of β-Aminopropionitrile (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Alkaline Hydrolysis of β-AminopropionitrileJared H. FordCite this: J. Am. Chem. Soc. 1945, 67, 5, 876–877Publication Date (Print):May 1, 1945Publication History Published online1 May 2002Published inissue 1 May 1945https://pubs.acs.org/doi/10.1021/ja01221a503https://doi.org/10.1021/ja01221a503research-articleACS PublicationsRequest reuse permissionsArticle Views173Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High speed multi-frequency impedance analysis of single biological particle using Maximum Length Sequences (2007)

A novel impedance spectroscopy technique has been developed for high speed single biological particle analysis. A microfluidic cytometer is used to measure the impedance of single micrometre sized latex particles at high speed across a range of frequencies. The setup uses a technique based on maximum length sequence (MLS) analysis, where the time-dependent response of the system is measured in the time domain and transformed into the impulse response using fast M-sequence transform (FMT). Finally fast Fourier transform (FFT) is applied to the impulse response to give the transfer-function of the system in the frequency domain. It is demonstrated that the MLS technique can give multi-frequency (broad-band) measurement in a short time period (ms). The impedance spectra of polystyrene micro-beads are measured at 512 evenly distributed frequencies over a range from 976.5625 Hz to 500 kHz. The spectral information for each bead is obtained in approximately 1 ms. Good agreement is shown between the MLS data and both circuit simulations and conventional AC single frequency measurements.
Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease (2016)

The complement pathway is activated in Alzheimer's disease. Here we show that the central complement factor C3 secreted from astrocytes interacts with microglial C3a receptor (C3aR) to mediate β-amyloid pathology and neuroinflammation in AD mouse models. Our study provides support for targeting C3aR as a potential therapy for Alzheimer's disease.
肅宗 45년, 국왕의 耆老所 입소 경위와 그 정치적 함의 (2012)

본 논문은 숙종 45년, 국왕의 耆老所 入所의 정치적 의미를 세자의 대리청정과 연계하여 분석한 것이다. 국왕의 耆老所 입소는 태조 이후 처음으로 환갑에 이른 국왕이 태조의 기로소 입소 고사를 재현한다는 명분 아래 이루어진 것이었다. 하지만 이 행사의 명분이 된 태조의 고사는 선조대 기로소의 중건으로 생성된 신뢰성이 없는 사적이었다. 논란에도 불구하고 기로소...
Electron Broadening Operator Including Penetrating Collisions for Hydrogen (2020)

The expression of the electron broadening operator including the effect of penetrating collisions, i.e., for which the incoming electron enters the extent of bound-electron wave-functions, is rather complicated, even for hydrogen. It involves integrals of special functions, the evaluation of which deserves scrutiny. We present a simple approximate form of the electron collision operator for hydrogen including penetration effects, both in direct and interference terms. The new expression is accurate and easy to compute. In the Penetration Standard Theory, the collision operator is convergent whatever the value of the maximum impact parameter. However, when penetration theory is not valid anymore, it should be questioned. We discuss the problem of strong collisions when penetration effects are taken into account.
Anti-Inflammatory Activity of Compounds Isolated from Plants (2001)

This review shows over 300 compounds isolated and identified from plants that previously demonstrated anti-inflammatory activity. They have been classified in appropriate chemical groups and data are reported on their pharmacological effects, mechanisms of action, and other properties.
The Effect of Bordetella Pertussis on the Antibody Response in Mice to Type III Pneumococcal Polysaccharide (1976)

The effect of an i.p. injection of Bordetella pertussis on the primary humoral immune response in mice to the thymus-independent antigen SIII has been studied. Suppression of the antibody response occurred when pertussis cells were injected at the same time as an optimal immunizing dose of SIII. In contrast, the antibody response to high doses of SIII was enhanced by B. pertussis. When SIII alone was injected, only 19S antibody was detected. However, when B. pertussis was administered with either optimal or high doses of SIII, 7S as well as 19S antibody against SIII was produced.
Construction of Combinatorial Libraries that Encode Zinc Finger-Based Transcription Factors (2010)

Combinatorial retroviral libraries of zinc finger transcription factors (ZF-TFs) can be constructed that encode tens of thousands of different, multi-finger zinc finger proteins (ZFPs) with distinct DNA-binding specificities, each of which is fused to a transcriptional activation or repression domain. Individual zinc fingers (ZFs) recognize their target DNA subsites and retain their binding specificities in the context of artificially constructed multi-finger ZFPs. Because of this modular nature, expression libraries that specify diverse multi-finger ZF-TFs can be created by the combinatorial stitching together of individual modules in a pool of single-ZF-encoding DNA segments. When these libraries are introduced into cells, the encoded ZF-TFs are expressed and can then activate or repress the transcription of endogenous target genes. Ideally, the ZF-TF-encoding retroviral vectors in the library enter cells randomly at a ratio of approximately 1 per cell. As a result, individual cells express different ZF-TFs and thus display distinct phenotypical changes. Using an appropriate screening or selection method, one can isolate clonal cells that display phenotypes of interest. One can then identify the ZF-TFs responsible for the phenotypes and, ultimately, the genes that are targeted by the selected ZF-TFs. Here, we provide protocols for the preparation of retroviral libraries that encode ZF-TFs for use in mammalian cells.
Pollen Specificity Elements Reside in 30 bp of the Proximal Promoters of Two Pollen-Expressed Genes (1995)

Yoram Eyal, Catherine Curie, Sheila McCormick, Pollen Specificity Elements Reside in 30 bp of the Proximal Promoters of Two Pollen-Expressed Genes, The Plant Cell, Vol. 7, No. 3 (Mar., 1995), pp. 373-384