gebhart/patrepeval huggingface dataset:
The distribution of HLA class II susceptible/protective haplotypes could partially explain the low incidence of type 1 diabetes in continental Italy (Lazio region) (2001)

HLA class II is the primary susceptibility gene to type 1 diabetes and the analysis of HLA class II association could help to clarify the relative weight of genetic contribution to the incidence of the disease. Here we present an extensive typing for HLA class II alleles and their haplotypes in a homogenous population of type 1 diabetic patients (n=134) and controls (n=128) and in simplex (n=100) and multiplex families (n=50) from continental Italy (Lazio region). Among the various haplotypes tested, the DRB1*0301-DQA1*0501-DQB1*0201 was the most frequent found in type 1 diabetic patients and was transmitted in 82% of affected siblings, whereas DRB1*0402-DQA1*0301-DQB1*0302 appeared to have the highest odds ratio (10.4), this haplotype was transmitted in 96.3% of affected siblings, followed by DRB1*0405-DQA1*0301-DQB1*0302, DRB1*0405-DQA1*0301-DQB1*0201, DRB1*0401-DQA1*0301-DQB1*0302 and DRB1*0404-DQA1*0301-DQB1*0302. The following haplotypes showed a significant decreased transmission to diabetic siblings: DRB1*0701-DQA1*0201-DQB1*0303, DR2-DQA1*01-DQB1*0602, DR5-DQA1*0501-DQB1*0301. We suggest that the HLA DR/DQ haplotype/genotype frequencies observed could in part explain the low incidence of type 1 diabetes registered in Lazio region (8.1/100.000/year), for a number of reasons: i) the low frequency, in the general control population, of the most susceptible haplotypes and genotype for type 1 diabetes DRB1*0301-DQA1*0501-DQB1*0201 (14%), and DR4-DQA1*0301-DQB1*0302 (9%) and DRB1*0301-DQA1*0501-DQB1*0201/DR4-DQA1*0301-DQB1*0302 (0.8%) compared to other countries characterised by high incidence rate of the disease, Sardinia and Finland, respectively; ii) a significant lower ratio, in the control population, between the susceptible DRB1*0301-DQA1*0501-DQB1*0201 and the neutral DRB1*0701-DQA1*0501-DQB1*0201 haplotypes compared to the Sardinian population; iii) the high frequency of protection haplotypes/genotypes as the DR5-DQA1*0501-DQB1*0301, and DR5-DQA1*0501-DQB1*0301/DR5-DQA1*0501-DQB1*0301 very common in the control population of Lazio region and the DRB1*1401-DQA1*0101-DQB1*0503 haplotype.
Ahead of the pack through vision and hustle: a case study of information technology at Rosenbluth Travel (2002)

Rosenbluth Travel has grown from a regional travel agency with $40 million in annual sales to one of the five largest agencies in the US, with sales of over $1 billion. Their strategy was based on exploiting the structural changes initiated by airline deregulation in 1978, including the growth of the corporate travel market and increasing economies of scale leading to consolidation. IT was a fundamental part of this strategy. The case sheds light on several theories on gaining competitive advantage through IT: technology leadership, leveraging critical resources, the role of IT infrastructure and switching costs. While these theories contribute to an explanation of Rosenbluth's success, a critical factor appears to be the vision to see an opportunity and the ability to hustle to exploit it.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Angiotensin II-Induced Production of Mitochondrial Reactive Oxygen Species: Potential Mechanisms and Relevance for Cardiovascular Disease (2012)

The development of antioxidant strategies specifically targeting mitochondria could be therapeutically beneficial in these disease conditions.
Immunotherapy of collagen-induced arthritis by a T-cell antiproliferative molecule. (1990)

The present study describes a novel experimental immunotherapeutic methodology for the reduction of inflammatory synovitis that is noted in an animal model of rheumatoid arthritis. The reduction in inflammation is noted in the animals administered a contra-interleukin-2 (IL-2) cytokine secreted by a cloned T-cell line. The mechanism of reduction of inflammation by this cytokine is through the inhibition of activation and differentiation of T lymphocytes. The cytokine inhibits the in vitro mitogen activation of T-cell lymphocytes as well as antigen-specific activation of a collagen type II specific T-cell line. In addition, decreased levels of messenger RNA coding for interleukin-2 are noted in T lymphocytes and IL-2 activation of the collagen type II specific cell line is inhibited by the contra-IL-2 cytokine. This initial description of a reduction in inflammation by a contra-IL-2 lymphokine suggests that immunoregulatory biologic molecules that are antagonists to IL-2 may be useful for the experimental immunotherapy of cartilage connective tissue pathology.
A miniaturized active vision system (2003)

The authors have developed a prototype miniaturized active vision system whose sensor architecture is based on a logarithmically structured space-variant pixel geometry. This system integrates a CCD sensor, miniature pan-tilt actuator, controller, general purpose processors and display. Due to the ability of space-variant sensors to cover large work-spaces yet provide high acuity with an extremely small number of pixels, space-variant active vision system architectures provide the potential for radical reductions in system size and cost. The authors describe a prototype space-variant active vision system which performs tasks such as moving object tracking and functions as a video telephone. The potential application domains for systems of this type include vision systems for mobile robots and robot manipulators, traffic monitoring systems, security and surveillance, and consumer video communications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Tracking unstable steady states: Extending the stability regime of a multimode laser system (1992)

It is shown that the unstable steady state of a multimode laser system may be stabilized by the occasional proportional feedback technique for dynamical control of chaotic systems. The range of pump excitations over which stabilization can be maintained is extended by more than an order of magnitude through application of a procedure for tracking the unstable steady state as the pump excitation is slowly varied.
Ductile Particle Toughening Of Hydroxyapatite Ceramics Using Platinum Particles (2004)

ABSTRACT: Bioceramics such as hydroxyapatites have low fracture toughness and this has limited their widespread use in medicine. In this paper we describe a method for incorporating, ductile platinum particles into a hydroxyapatite matrix in order to improve the fracture toughness. The fracture toughness of the composite was measured using a Vickers indentation technique and the effect of volume fraction of platinum particles on the fracture toughness was determined and compared with predictions based on models in the literature. The results indicated that the incorporation of the particles improved the measured fracture toughness of the composite in a manner consistent with that predicted in the literature. 1
A low-energy chilled ammonia process exploiting controlled solid formation for post-combustion CO<sub>2</sub>capture (2016)

A new ammonia-based process for CO<sub>2</sub> capture from flue gas has been developed, which utilizes the formation of solid ammonium bicarbonate to increase the CO<sub>2</sub> concentration in the regeneration section of the process. Precipitation, separation, and dissolution of the solid phase are realized in a dedicated process section, while the packed absorption and desorption columns remain free of solids. Additionally, the CO<sub>2</sub> wash section applies solid formation to enable a reduction of the wash water consumption. A rigorous performance assessment employing the SPECCA index (Specific Primary Energy Consumption for CO<sub>2</sub> Avoided) has been implemented to allow for a comparison of the overall energy penalty between the new process and a standard ammonia-based capture process without solid formation. A thorough understanding of the relevant solid-solid-liquid-vapor phase equilibria and an accurate modeling of them have enabled the synthesis of the process, and have inspired the development of the optimization algorithm used to screen a wide range of operating conditions in equilibrium-based process simulations. Under the assumptions on which the analysis is based, the new process with controlled solid formation achieved a SPECCA of 2.43 MJ kg<sub>CO<sub>2</sub></sub><sup>-1</sup>, corresponding to a reduction of 17% compared to the process without solid formation (with a SPECCA of 2.93 MJ kg<sub>CO<sub>2</sub></sub><sup>-1</sup>). Ways forward to confirm this significant improvement, and to increase the accuracy of the optimization are also discussed.
<i>Borrelia burgdorferi</i> in Joint Fluid in Chronic Lyme Arthritis (1986)

Although indirect evidence suggests that chronic Lyme arthritis is caused by persistent infection with Borrelia burgdorferi, direct visualization has been lacking. We report the demonstration of B. burgdorferi from synovial fluid aspirated from the right knee of a 31-year-old man with Lyme arthritis for more than 1 year. After 6 days, culture medium inoculated with synovial fluid showed one motile and several nonmotile spirochetes. Direct immunofluorescence staining showed reactivity with anti-B. burgdorferi serum. Spirochetes were not seen in subcultured material. The patient's arthritis improved with high-dose intravenous penicillin. Identification of B. burgdorferi from the joint fluid of a patient with long-standing arthritis supports the concept that the arthritis is due to persistent infection.
Polarization Selective Magnetic Vortex Dynamics and Core Reversal in Rotating Magnetic Fields (2008)

We report on the observation of magnetic vortex dynamics in response to rotating magnetic fields in submicron platelets. Unlike linear fields or spin polarized currents, which excite both vortex core polarization states, an in-plane rotating field can selectively excite one of the polarization states. We demonstrate by direct imaging with time-resolved scanning x-ray microscopy that the rotating field only excites the gyrotropic mode if the rotation sense of the field coincides with the vortex gyration sense and that such a field can selectively reverse the vortex polarization.
Adecuación del método de pirámide para mejorar la coordinación intramuscular y desarrollo de la fuerza muscular a corto plazo, aplicado a un grupo de pacientes hemiparéticos atendidos en el Centro Internacional de Restauración Neurológica. (2006)

Las afecciones neurologicas son unos de los motivos de consulta medica actuales y particularmente los accidentes vasculares encefalicos (AVE) que constituyen la causa mas frecuente de enfermedad neurologica y la tercera causa de muerte. La hemiplejia es el sindrome neurologico por excelencia. Estas afecciones les ocasionan a estos pacientes una disminucion sustancial de las capacidades fisicas y deterioro de la fuerza muscular. Pues en muchos casos su capacidad queda limitada. El objetivo del trabajo es demostrar que el metodo de piramide modificado permite desarrollar la fuerza y coordinacion intramuscular a corto plazo. Se tomo una muestra de 15 pacientes con AVE de tipo hemorragico, los que se evaluaron al inicio y al final del periodo de tratamiento de 28 dias a traves de un test de esfuerzo maximo para extremidades inferiores y ademas se utilizo el indice de Barthel, seleccionando 3 areas de las 10 que componen todo el test (traslado silla cama, deambulacion y escalones), las que son a fines a las caracteristicas de nuestro trabajo. En los resultados es importante senalar la asimilacion por parte de los pacientes de este metodo donde en la muestra en su inicio se apreciaba una debilidad marcada en el hemicuerpo afectado; ya a mediados del tratamiento se percibia un incremento rapido de la fuerza. Al final del tratamiento se alcanzo un aumento de la fuerza muscular por encima del 50%, propiciando esto la deambulacion en la generalidad de los pacientes al menos con bastones, con mucho mas independencia en algunas tareas de la vida diaria.
A CONSTRAINED NON-RIGID REGISTRATION ALGORITHM FOR APPLICATION IN PROSTATE RADIOTHERAPY (2007)

This paper presents a novel free-form deformation registration algorithm with non-rigid constraints to capture the transformation between the planning day and treatment day CT images used for external beam radiotherapy for prostate cancer. The algorithm is constrained to the predetermined motion of a segmented organ, which is described by an injective free-form deformation (FFD) based on B-splines. The end goal is for the injective transformation to be used to update the radiotherapy plan to take into account bone and soft tissue deformation. The results of the algorithm have been compared to those achieved using rigid and fully non-rigid registration. The results clearly indicate that the constrained non-rigid registration algorithm presented in this paper performed much better at capturing the motion of the constrained organ, the bladder in this case, than the rigid or fully non-rigid registration algorithms.
VLSI computing architectures for Haar transform (1990)

The Haar transform is very useful in many signal and image processing applications where real-time implementation is essential. Three VLSI computing architectures are proposed for fast implementation of the Haar transform. Comparisons on the advantages and disadvantages of the proposed architectures are also presented.
Experimental Studies of the Pathogenesis of Infections due to Pseudomonas aeruginosa: Immunization Using Divalent Flagella Preparations (1986)

Flagella preparations of the two antigenic types that make up all the flagella antigens in Pseudomonas aeruginosa were used, individually, to immunize mice. Mice thus immunized were protected when burned and infected with P. aeruginosa. Protection was specific for the flagella antigen of the challenge strain but independent of its somatic antigen. When both antigens were used, together, for immunization, protection was independent of both the flagella and somatic antigen of the challenge strain. These results suggest that a divalent P. aeruginosa 'vaccine' would be of considerable value for immunoprophylaxis in burn patients.
Hydrogenation of conjugated diolefins with transition metal .pi.-complexes (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogenation of conjugated diolefins with transition metal .pi.-complexesYoshio Tajima and Etsuo KuniokaCite this: J. Org. Chem. 1968, 33, 4, 1689–1690Publication Date (Print):April 1, 1968Publication History Published online1 May 2002Published inissue 1 April 1968https://pubs.acs.org/doi/10.1021/jo01268a097https://doi.org/10.1021/jo01268a097research-articleACS PublicationsRequest reuse permissionsArticle Views176Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chances and limitations of high-power diode lasers (2004)

Great expectations were expressed about the future of high power diode lasers for direct materials processing applications, when they have been introduced in the mid-nineties. Nevertheless, based on their technology, there are physical limitations, especially if beam quality is considered: Kilowatt power must be generated from individual elements, which do not provide more than a few watts for the time being, if they shall last for a reasonable time; such elements are incoherently combined. In this article the technology will be analyzed about their potential and a comparison with "conventional" high power lasers will be performed. Fortunately not all laser materials processing techniques require extremely high power density, i.e. high beam quality, but rather need a larger spot or a spot with a special shape. Such applications are the niches for the highly efficient and reliable diode lasers. In this context, high power diode lasers have proven to be a perfect supplement to the existing CO<sub>2</sub> and Nd:YAG materials processing lasers rather than a competitor for them.
A Portable Vehicular Navigation System Using High Sensitivity GPS Augmented with Inertial Sensors and Map-matching (2004)

<div class="htmlview paragraph">A Global Positioning System (GPS) technology development known as high sensitivity GPS (HSGPS) can significantly improve availability in challenging environments such as in urban canyons where standard GPS performance is extremely poor. However, this technology could produce higher measurement noise, multipath and cross-correlation errors resulting in position errors of hundreds of metres in such cases. The use of internal filtering with “heavy” constraints provides better results in some cases but may result in major biases and overshooting effects in other cases. This paper develops a portable vehicle navigation system by aiding a standalone HSGPS receiver with self-contained inertial sensors and map-matching. Since traditional GPS error estimation methods are shown to be invalid in urban canyon environments for HSGPS, nontraditional data fusion algorithms are needed for augmenting HSGPS with self-contained sensors (<span class="xref">MacGougan et al, 2002</span>). A unique map-matching technique is presented that uses both position and velocity measurements and works with a vehicle dynamics model. The model provides a means to assess the quality of HSGPS measurements and therefore an integration mechanism for inertial sensors. The integrated system was tested in a suburban area as well as in a downtown core with buildings of 10 to 50 stories and mask angles of up to 80 degrees. The system performance under severe GPS signal degradation and multipath conditions is presented.</div>
An ultra-low power operating technique for mega-pixels current-mediated CMOS imagers (2004)

A novel ultra-low power operating technique is presented for mega-pixels current-mediated CMOS imagers. In the proposed technique, the reset and read-out phases occur simultaneously: as a single pixel is being read-out another pixel is being reset. Such a strategy reduces power consumption by more than 2 orders of magnitude for current- mediated mega-pixels CMOS imagers, while still allowing for on-read-out fixed pattern noise correction. Power consumption becomes independent of both read-out speed and imager array size. Additionally, the proposed operating technique leads to improved linearity for the pixel response, increased dynamic range as well as on-chip digital shutter functionality. A single additional address decoder is required to generate the reset signals, resulting in a marginal increase in silicon area. The wiring overhead is kept to a minimum with only a single control signal required to operate the current- mediated CMOS imager.
Optical local area networking using CWDM (2003)

This paper describes the current status of Coarse Wavelength Division Multiplexing (CWDM), and then progresses to discuss how it may evolve in networking applications in the future. As WDM can enhance not only transmission but also networking systems, the paper reports a potentially low cost WDM based access node architecture, particularly suited for routing optical data packets on nanosecond timescales. The scheme is cascadable and involves the use of a simple semiconductor optical amplifier (SAO) based add-drop switch. Preliminary results concerning the operation of the add-drop switches under multi-wavelength operation are reported.
Nature of the dominant deep trap in amorphous silicon nitride (1988)

We observe a strong correlation between changes in the density of paramagnetic silicon-``dangling-bond'' centers and changes in the space-charge density in amorphous silicon nitride films subjected alternately to positive and negative charge injection and optical illumination. Our results provide, for the first time, direct experimental evidence associating a specific point defect with the trapping phenomena in amorphous silicon nitride. We also demonstrate both directly and for the first time the amphoteric nature of the silicon nitride silicon-dangling-bond center.
Comparison of Surface Plasmon Resonance Imaging and Enzyme-Linked Immunosorbent Assay for the Detection of Antibodies against Iridovirus in Rock Bream (<i>Oplegnathus Fasciatus</i>) (2007)

A protein chip based on surface plasmon resonance imaging (SPRI) was developed for detecting fish iridovirus antibody using a recombinant 50-kDa fragment of major capsid protein (MCP) as an antigen. The diagnostic potential of SPRI for measuring antibodies to the iridovirus MCP was compared with that of a conventional enzyme-linked immunosorbent assay (ELISA) using 40 juvenile rock bream (Oplegnathus fasciatus) serum samples in a nursery. There was a strong positive correlation between the SPRI and ELISA (n = 40, r = 0.939, P < 0.01). Therefore, this recombinant 50-kDa MCP can be used as an antigen for serological studies, and the SPRI, which is a label-free and high-throughput method, is potentially a valuable tool in the serodiagnosis of an iridoviral infection.
Time Signature Detection by Using a Multi Resolution Audio Similarity Matrix (2007)

A method that estimates the time signature of a piece of music is presented. The approach exploits the repetitative structure of most music, where the same musical bar is repeated in different parts of a piece. The method utilised a multi-resolution audio similarity matrix approach, which allows comparisons between longer audio segments (bars) by combining comparisons of shorter segments (fraction of a note). The time signature method only depends on musical structure, and does not depend on the presence of percussive instruments or strong musical accents.
Mercury Delay Line Memory Using a Pulse Rate of Several Megacycles (1949)

A mercury delay line memory system for electronic computers, capable of operating at pulse repetition rates of several megacycles per second, has been developed. The high repetition rate results in a saving in space and a reduction in access time. Numerous improvements in techniques have made the high repetition rate possible. The use of the pulse envelope system of representing data has effectively doubled the possible pulse rate; the use of crystal gating circuits has made possible the control of signals at high pulse rates; and a multichannel memory using a single pool of mercury has simplified the mechanical construction, reduced the size, and made temperature control much easier. The memory system described makes possible a significant increase in the over-all speed of an electronic computer.
A new approach to the economic analysis of projects (1979)

The calculation of an economic rate of return has become a standard feature of project evaluation. Yet, as traditionally defined, the rate of return does not focus adequately on the scarcity of investable resources faced by developing countries, nor on their need to alleviate extreme poverty. A new approach in project analysis has therefore been developed which provides a framework designed to assist systematic decision making in this area.