gebhart/patrepeval huggingface dataset:
Association of Left Atrial Function and Left Atrial Enhancement in Patients With Atrial Fibrillation (2015)

Increased LA enhancement is associated with decreased LA reservoir, conduit, and booster pump functions. Phasic measurement of LA function using feature-tracking cardiac magnetic resonance may add important information about the physiological importance of LA fibrosis.
Recent Advances in FPGA Reverse Engineering (2018)

In this paper, we review recent advances in reverse engineering with an emphasis on FPGA devices and experimentally verified advantages and limitations of reverse engineering tools. The paper first introduces essential components for programming Xilinx FPGAs (Xilinx, San Jose, CA, USA), such as Xilinx Design Language (XDL), XDL Report (XDLRC), and bitstream. Then, reverse engineering tools (Debit, BIL, and Bit2ncd), which extract the bitstream from the external memory to the FPGA and utilize it to recover the netlist, are reviewed, and their limitations are discussed. This paper also covers supplementary tools (Rapidsmith) that can adjust the FPGA design flow to support reverse engineering. Finally, reverse engineering projects for non-Xilinx products, such as Lattice FPGAs (Icestorm) and Altera FPGAs (QUIP), are introduced to compare the reverse engineering capabilities by various commercial FPGA products.
Role of Bovine Albumin in a Serum-free Suspension Cell Culture Medium (1975)

A serum-free culture medium, supplemented with 1% bovine serum albumin, supported the growth of both primary and continuous suspension-type cultures of various mammalian tumor cells. The role of albumin added to the medium was also studied. Defatted albumin failed to support cell growth, unless reconstituted with its lipid extract. Similarly, defatted albumin when combined with oleic and linoleic acids, also supported cell growth. Therefore, albumin-bound fatty acids play an important growth-promoting role in serum-free medium.
Gluten and the Gut--Lessons for Immune Regulation (2002)

Celiac sprue is a common disease in which an immune response to the gluten in wheat results in an inflammatory reaction in the small intestine that can prevent the absorption of nutrients. In a Perspective,
 Schuppan and Hahn
 discuss new work (Shan et al .) that identifies a 33-amino acid peptide in gluten that contains the major immunogenic epitopes. This discovery opens the door to developing therapeutic strategies to treat celiac sprue by destroying this peptide.
Palladium-Catalyzed Cross-Coupling Reactions of Paramagnetic Vinyl Bromides and Paramagnetic Boronic Acids (2006)

Suzuki reactions are utilized for the synthesis of heterobifunctional cross-linking reagents (thiol- or aminospecific and photoactivatable), polyaromatics (such as phenanthrene) and heterocycles (such as coumarin and quinoline), anellated nitroxides and paramagnetic, biologically active molecules (such as cis-stilbene and nicotinamide). Furthermore, the synthesis of new vinyl and allyl boronic acid esters is also reported.
Activated T lymphocytes and macrophages secrete fibronectin which strongly supports cell adhesion (1992)

Matrix-bound fibronectin (FN) appears to be involved in cell adhesion and motility mediated by integrin receptors. Although lymphoid cells and other cell types are capable of producing and secreting FN, the precise role of this secreted FN-like factor in regulating immune reactions is unclear. In the present study we analyzed the adhesive properties of FN secreted by rat CD4+ T cells and clone cells activated by the T cell mitogen concanavalin A (Con A), antigen, or via the CD2 pathways, or by macrophages (M phi) activated by lipopolysaccharide (LPS). Immobilized culture supernatant (CS) from the activated T cells or M phi supports the adhesion of activated rat or human CD4+ T cell or murine tumor cell. These CS contained FN and were more potent at facilitating cell adhesion then plasma FN. The adhesion activity of CS was attributed to FN because (a) gelatin columns depleted the FN present in the CS and (b) pretreating the cells with peptides of the cell-binding domain of FN abrogated their ability to bind CS. CS-mediated adhesion appears to occur primarily via the recognition of the Arg-Gly-Asp (RGD) by the beta 1-integrin-specific receptors of the adhesive cells. Thus, we postulate that FN secreted by various types of leukocytes is involved in promoting essential cell-matrix interactions, possibly affecting cell-adhesive and migratory processes at inflammatory or extravasation sites.
High Yields of 2,3-Butanediol and Mannitol in Lactococcus lactis through Engineering of NAD <sup>+</sup> Cofactor Recycling (2011)

Manipulation of NADH-dependent steps, and particularly disruption of the las-located lactate dehydrogenase (ldh) gene in Lactococcus lactis, is common to engineering strategies envisaging the accumulation of reduced end products other than lactate. Reverse transcription-PCR experiments revealed that three out of the four genes assigned to lactate dehydrogenase in the genome of L. lactis, i.e., the ldh, ldhB, and ldhX genes, were expressed in the parental strain MG1363. Given that genetic redundancy is often a major cause of metabolic instability in engineered strains, we set out to develop a genetically stable lactococcal host tuned for the production of reduced compounds. Therefore, the ldhB and ldhX genes were sequentially deleted in L. lactis FI10089, a strain with a deletion of the ldh gene. The single, double, and triple mutants, FI10089, FI10089ΔldhB, and FI10089ΔldhBΔldhX, showed similar growth profiles and displayed mixed-acid fermentation, ethanol being the main reduced end product. Hence, the alcohol dehydrogenase-encoding gene, the adhE gene, was inactivated in FI10089, but the resulting strain reverted to homolactic fermentation due to induction of the ldhB gene. The three lactate dehydrogenase-deficient mutants were selected as a background for the production of mannitol and 2,3-butanediol. Pathways for the biosynthesis of these compounds were overexpressed under the control of a nisin promoter, and the constructs were analyzed with respect to growth parameters and product yields under anaerobiosis. Glucose was efficiently channeled to mannitol (maximal yield, 42%) or to 2,3-butanediol (maximal yield, 67%). The theoretical yield for 2,3-butanediol was achieved. We show that FI10089ΔldhB is a valuable basis for engineering strategies aiming at the production of reduced compounds.
Knowledge Graph Embedding via Graph Attenuated Attention Networks (2019)

Knowledge graphs contain a wealth of real-world knowledge that can provide strong support for artificial intelligence applications. Much progress has been made in knowledge graph completion, state-of-the-art models are based on graph convolutional neural networks. These models automatically extract features, in combination with the features of the graph model, to generate feature embeddings with a strong expressive ability. However, these methods assign the same weights on the relation path in the knowledge graph and ignore the rich information presented in neighbor nodes, which result in incomplete mining of triple features. To this end, we propose Graph Attenuated Attention networks(GAATs), a novel representation method, which integrates an attenuated attention mechanism to assign different weight in different relation path and acquire the information from the neighborhoods. As a result, entities and relations can be learned in any neighbors. Our empirical research provides insight into the effectiveness of the attenuated attention-based models, and we show significant improvement compared to the state-of-the-art methods on two benchmark datasets WN18RR and FB15k-237.
Edge detection algorithm of image fusion based on improved Sobel operator (2017)

The traditional Sobel operator has low edge localization accuracy, poor noise and edge detection continuity. In order to solve these problems, this paper proposes an image fusion algorithm combining fusion improved Sobel operator, Canny operator and LoG operator to optimize edge detection results. First, we use the Morphological smoothing to preprocess the image of the cigarette packet, and keep the edge information and remove the noise. Secondly, we extend the template of the vertical and horizontal directions of the traditional Sobel operator, and increase the 6-direction template, and enhance the edge extraction ability. Then, we use the Otsu method to apply the threshold. Finally, in order to optimize the edge detection effect, the image fusion method proposed in this paper is used to deal with the experiment. The experimental results show that the image fusion method has a much higher edge detection effect than the traditional Sobel operator.
Cox17 Is Functional When Tethered to the Mitochondrial Inner Membrane (2004)

Cox17 is an essential protein in the assembly of cytochrome c oxidase within the mitochondrion. Cox17 is implicated in providing copper ions for formation of CuA and CuB sites in the oxidase complex. To address whether Cox17 is functional in shuttling copper ions to the mitochondrion, Cox17 was tethered to the mitochondrial inner membrane by a fusion to the transmembrane domain of the inner membrane protein, Sco2. The copper-binding domain of Sco2 that projects into the inter-mitochondrial membrane space was replaced with Cox17. The Sco2/Cox17 fusion protein containing the mitochondrial import sequence and transmembrane segment of Sco2 is exclusively localized within the mitochondrion. The Sco2/Cox17 protein restores respiratory growth and normal cytochrome oxidase activity in cox17Delta cells. These studies suggest that the function of Cox17 is confined to the mitochondrial intermembrane space. Domain mapping of yeast Cox17 reveals that the carboxyl-terminal segment of the protein has a function within the intermembrane space that is independent of copper ion binding. The essential C-terminal function of Cox17 maps to a candidate amphipathic helix that is important for mitochondrial uptake and retention of the Cox17 protein. This motif can be spatially separated from the N-terminal copper-binding functional motif. Possible roles of the C-terminal motif are discussed.
Proteomic Identification of Carbonylated Proteins and Their Oxidation Sites (2010)

Excessive oxidative stress leaves a protein carbonylation fingerprint in biological systems. Carbonylation is an irreversible post-translational modification (PTM) that often leads to the loss of protein function and can be a component of multiple diseases. Protein carbonyl groups can be generated directly (by amino acids oxidation and the alpha-amidation pathway) or indirectly by forming adducts with lipid peroxidation products or glycation and advanced glycation end-products. Studies of oxidative stress are complicated by the low concentration of oxidation products and a wide array of routes by which proteins are carbonylated. The development of new selection and enrichment techniques coupled with advances in mass spectrometry are allowing the identification of hundreds of new carbonylated protein products from a broad range of proteins located at many sites in biological systems. The focus of this review is on the use of proteomics tools and methods to identify oxidized proteins along with specific sites of oxidative damage and the consequences of protein oxidation.
Phase Detection Based on the Lock-in Amplifier SR844 and Experiments of Brain Neuron Cells in MIT System (2008)

To implement a function of detecting phase change at a high precision in MIT system, a phase-change- detecting unit based on RF Lock-in Amplifier SR844 was designed at the frequency of 1 MHz. The unit provided a gain range of 3.52 dB ~ 61.1 dB and a phase resolution by 0.02 deg. And an experiment with neuron cell model from SD rat cortex was made to detect phase change produced by edema neuron cell model and normal neuron cell model respectively. The results of the experiment showed that the phase change produced by edema neuron cell model was smaller than that by normal neuron cell model and that the unit had good capability of detecting the phase change produced by edema neuron cell model and normal neuron cell model effectively. These may be of great help for further cerebral edema-detecting work.
Molecular and cellular effects of Auger emitters: 2008–2011 (2012)

Significant progress can be reported for targeting methods and improvements in methods to accumulate Auger emitters in the target cells, as well as advances in dose calculations. These studies further our understanding of how Auger emitters induce cell death at a cellular and molecular level, supporting the targeted radiomedical applications of Auger emitters.
Genetic Behavior of R Factors in <i>Vibrio cholerae</i> (1972)

The fi(+) and fi(-) R factors are unstable in Vibrio cholerae even on selective media containing antibiotics, although a temperature-sensitive kanamycin resistance factor and its recombinants are stably maintained in V. cholerae at low temperatures.
Investigation of the gelation mechanism in .kappa.-carrageenan/konjac mannan mixtures using differential scanning calorimetry and electron spin resonance spectroscopy (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigation of the gelation mechanism in .kappa.-carrageenan/konjac mannan mixtures using differential scanning calorimetry and electron spin resonance spectroscopyP. A. Williams, S. M. Clegg, M. J. Langdon, K. Nishinari, and L. PiculellCite this: Macromolecules 1993, 26, 20, 5441–5446Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ma00072a023https://doi.org/10.1021/ma00072a023research-articleACS PublicationsRequest reuse permissionsArticle Views608Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
태권도지도자 리더십유형 및 선수의 성취목표성향이 자아실현에 미치는 영향 (2009)

본 연구는 태권도 지도자의 리더십유형 및 선수들의 성취목표성향이 자아실현에 어떠한 영향을 미치는지를 분석하는데 연구의 목적이 있다. 본 연구의 대상은 대한태권도협회의 선수로 등록된 중·고·대학생 태권도 선수를 모집단으로 설정하여 군집표집과 유층집락표집의 방법을 이용하여 총 650부의 설문지 중 571부의 응답 자료를 분석하였으며, 통계처리는 Window용 SPSS 12.0을 이용하여 빈도분석, 신뢰도분석, 요인분석, 중다회귀 분석을 사용한 결과 다음과 같은 결론을 얻었다. 태권도지도자의 리더십유형 및 선수의 성취목표성향이 자아실현의 관계에서 과제목표와 혁신주의가 능력발휘에, 자기목표와 참여주의가 능력개발에, 과제목표와 혁신주의가 이상실현에 영향을 미치는 것으로 나타났다. 이상의 결론에서 태권도 선수들은 강한 훈련으로 기량을 향상시키며 시합에서의 좋은 성적을 향한 시합 전략을 잘 세우는 지도자를 선호하며 노력과 협동을 중시하며 특히 고등학생에게 높은 과제목표성향이 나타나는 것은 대학 진학을 위한 노력이 운동 경력과 입상 경력과도 무관하지 않음을 알 수 있었다. 태권도에의 지속적인 참여는 자아실현의 하위요인 중 이상실현에 많은 영향을 미치며 이는 태권도가 경기의 스포츠적인 측면은 물론 태권도에 내재한 태권도 정신과 무도철학의 인성교육에 의한 것으로 사료된다.
A Novel NE-dlg/SAP102-associated Protein, p51-nedasin, Related to the Amidohydrolase Superfamily, Interferes with the Association between NE-dlg/SAP102 and N-Methyl-d-aspartate Receptor (1999)

The membrane-associated guanylate kinase proteins have been known to interact various membrane receptors with their N-terminal segments designated the PDZ domains and to cluster these receptors at the target site of the cell membrane. NE-dlg/SAP102, a neuronal and endocrine tissue-specific MAGUK family protein, was found to be expressed in both dendrites and cell bodies in neuronal cells. Although NE-dlg/SAP102 localized at dendrites was shown to interact with N-methyl-D-aspartate receptor 2B via the PDZ domains to compose postsynaptic density, the binding proteins existing in the cell body of the neuron are still unknown. Here we report the isolation of a novel NE-dlg/SAP102-associated protein, p51-nedasin. Nedasin has a significant homology with amidohydrolase superfamily proteins and shows identical sequences to a recently identified protein that has guanine aminohydrolase activity. Nedasin has four alternative splice variants (S, V1, V2, and V3) that exhibited different C-terminal structures. NE-dlg/SAP102 is shown to interact with only the S form of nedasin which is predominantly expressed in brain. The expression of nedasin in neuronal cells increases in parallel with the progress of synaptogenesis and is mainly detected in cell bodies where it co-localizes with NE-dlg/SAP102. Furthermore, nedasin interferes with the association between NE-dlg/SAP102 and NMDA receptor 2B in vitro. These findings suggest that alternative splicing of nedasin may play a role in the formation and/or structural change in synapses during neuronal development by modifying clustering of neurotransmitter receptors at the synaptic sites.
Phosphorylation Is Required for Alteration of Kv1.5 K+ Channel Function by the Kvβ1.3 Subunit (1999)

The Kv1.5 K(+) channel is functionally altered by coassembly with the Kvbeta1.3 subunit, which induces fast inactivation and a hyperpolarizing shift in the activation curve. Here we examine kinase regulation of Kv1.5/Kvbeta1.3 interaction after coexpression in human embryonic kidney 293 cells. The protein kinase C inhibitor calphostin C (3 microM) removed the fast inactivation (66 +/- 1.9 versus 11 +/- 0.25%, steady state/peak current) and the beta-induced hyperpolarizing voltage shift in the activation midpoint (V(1/2)) (-21.9 +/- 1.4 versus -4.3 +/- 2.0 mV). Calphostin C had no effect on Kv1.5 alone with respect to inactivation kinetics and V(1/2). Okadaic acid, but not the inactive derivative, blunted both calphostin C effects (V(1/2) = -17.6 +/- 2.2 mV, 38 +/- 1.8% inactivation), consistent with dephosphorylation being required for calphostin C action. Calphostin C also removed the fast inactivation (57 +/- 2.6 versus 16 +/- 0.6%) and the shift in V(1/2) (-22.1 +/- 1.4 versus -2.1 +/- 2.0 mV) conferred onto Kv1.5 by the Kvbeta1.2 subunit, which shares only C terminus sequence identity with Kvbeta1. 3. In contrast, modulation of Kv1.5 by the Kvbeta2.1 subunit was unaffected by calphostin C. These data suggest that Kvbeta1.2 and Kvbeta1.3 subunit modification of Kv1.5 inactivation and voltage sensitivity require phosphorylation by protein kinase C or a related kinase.
Preparation and Properties of N-Methylol, N-Alkoxymethyl and N-Alkylthiomethyl Polyamides (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and Properties of N-Methylol, N-Alkoxymethyl and N-Alkylthiomethyl PolyamidesTheodore L. Cairns, Henry D. Foster, Arthur W. Larchar, Allan K. Schneider, and Richard S. SchreiberCite this: J. Am. Chem. Soc. 1949, 71, 2, 651–655Publication Date (Print):February 1, 1949Publication History Published online1 May 2002Published inissue 1 February 1949https://pubs.acs.org/doi/10.1021/ja01170a074https://doi.org/10.1021/ja01170a074research-articleACS PublicationsRequest reuse permissionsArticle Views402Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
"Microcontrollers and fuzzy logic for embedded control applications" (2002)

Only a minority of the fuzzy logic applications in existence today could be described as embedded control solutions. Although this number is expected to grow, most of the users benefitting from fuzzy today are involved in process and industrial control environments where very often the platform for fuzzy is a PC. In both situations, fuzzy may be applied in a relatively straightforward manner, however implementing fuzzy logic on a microcontroller gives rise to many more options to be given consideration.
Pharmacology of Store-operated Calcium Channels (2010)

Store-operated calcium entry is a process by which the depletion of calcium from the endoplasmic reticulum activates calcium influx across the plasma membrane. In the past few years, the major players in this pathway have been identified. STIM1 and STIM2 function as calcium sensors in the endoplasmic reticulum and can interact with and activate plasma membrane channels comprised of Orai1, Orai2, or Orai3 subunits. This review discusses recent advances in our understanding of this widespread signaling mechanism as well as the mechanisms by which a number of interesting pharmacological agents modify it.
Role of Riboflavin- and UV Light-Treated Plasma in Prevention of Transfusion-Related Acute Lung Injury (2014)

Thanks to its readiness, simplicity and feasibility, riboflavin- and UV light-treated FFP implementation can facilitate the preferential use of FFP from male donors as a TRALI prevention strategy.
Using Avian Morphology to Enhance Aircraft Maneuverability (2006)

Birds are perhaps the most versatile and graceful flying objects in the atmosphere. Even in complex urban environments, they are able to rapidly change shape to transition from efficient cruise to aggressive maneuvering and precision descents. Avian morphology permits a wide range of wing configurations, each of which may be used for a particular flight task. The shapes into which birds morph are of considerable interest for small UAVs, whose typically-fixed geometries preclude similarly-diverse maneuverability. Simple mechanical analogues to bird wing structures can be used to expand the flight envelope for conventional UAVs. Aerodynamic and dynamic metrics are used to determine optimal shapes for various missions within the configuration space afforded by the morphing wings. Computational aerodynamics are used to estimate the performance and dynamic characteristics of each wing shape. Classical mission objectives such as long range cruise, endurance loitering, and minimum radius turns are used to identify appropriate wing shapes for each mission. Other tasks such as steep descents and sensor-pointing are designed to enhance the operation of UAVs in the vicinity of urban obstacles. The optimized wing geometries are found to converge to biological solutions in several instances. A mission profile example is presented to illustrate the performance improvement resulting from morphing. Transient morphing between tasks is achieved using a simple approach where configuration trajectories move towards the shape goal while avoiding areas of undesirable dynamics. The configuration change is controlled using a set of stability criteria, which can guarantee pilotability or controllability for all morphing conditions.