gebhart/patrepeval huggingface dataset:
Wesen und Wahrscheinlichkeit eines zukünftigen Krieges (1967)

Die Architekten der sowjetischen strategischen Politik sehen sich einer Aufgabe gegenüber, die nicht grundsätzlich unähnlich der ist, vor die in der Welt von heute die Führung jeder Großmacht gestellt ist. Erstens müssen sie entscheiden, welche im Bereich des dem Lande Möglichen liegende strategische Haltung am besten den Ausbruch eines nuklearen Krieges verhindern und die politische Strategie des Landes allgemein fördern kann. Zweitens müssen sie überlegen, wie das Land einen Krieg — sollte es zu einem solchen kommen — führen könnte, und welche Kräfte und Maßnahmen für diesen Zweck notwendig sein würden.
Deposition of silicon alloys in an integrated distributed electron cyclotron resonance reactor: Oxide, nitride, oxinitrides, and multilayer structures (2002)

The films of SiOxNy were deposited in an integrated distributed electron cyclotron resonance reactor. Due to planar geometry, such deposition processes can be scaled-up for processing of large areas. Deposition kinetics and material properties were studied in order to find the common principles for obtaining faster growth rates and more uniform deposition of high quality films. Films were grown without bias at room temperature from mixtures of SiH4, O2, and N2 at high deposition rates (more than 4.5 nm/s for silica). Optical properties of the films were analyzed using ultraviolet (UV)-visible and infrared spectroscopic ellipsometry. The influence of gas flows, temperature, pressure, microwave power, and rf bias was investigated. A multilayer optical filter was grown on a polycarbonate substrate using a UV-visible ellipsometer to control the deposition process. The success of this test confirms the accuracy of the experimental results and shows high promise for the technology.
Health statistics for the Americas (1994)

The Banks World Development Report 1993: Investing in Health (WDR) presented data on health conditions services and expenditures for countries in the Americas. Countries in the region with populations of less than 3 million were however excluded from the document. This paper expands and updates the WDR in appendix tables for the countries of Latin America the Caribbean Canada and the US. Data for countries of population less than 3 million have been added data from Canada and the US were added and some statistics have been updated on the basis of recent data. Data are presented by subject and by country while country profiles have been added to the topical tables to facilitate use. The comparison with other global figures and with the developing world as a whole have been retained. Technical notes on methods and data sources comprise the closing section. This document will be updated every few years if it proves useful.
The grounds for researching the business network efficiency (2014)

The aim of this article is to present the grounds for researching the business network efficiency. The efficiency assessment of business network needs a multi-level approach which reflects the complexity of economic relationships formed in them. In particular the article shows: the network effects, efficiency of collaboration within networks and the theses of the proposed  concept for researching the business network efficiency which may be the foundation for the diagnostic and project works.
Wireless Power Transfer System Architectures for Portable or Implantable Applications (2016)

This paper discusses the near-field inductive coupling wireless power transfer (WPT) at the system level, with detailed analyses on each state-of-the-art WPT output voltage regulation topologies. For device miniaturization and power loss reduction, several novel architectures for efficient WPT were proposed in recent years to reduce the number of passive components as well as to improve the system efficiency or flexibility. These schemes are systematically studied and discussed in this paper. The main contribution of this paper is to provide design guidelines for WPT system design. In addition, possible combinations of the WPT building block configurations are summarized, compared, and investigated for potential new architectures.
GT160-246, a Toxin Binding Polymer for Treatment of <i>Clostridium difficile</i> Colitis (2001)

GT160-246, a high-molecular-weight soluble anionic polymer, was tested in vitro and in vivo for neutralization of Clostridium difficile toxin A and B activities. Five milligrams of GT160-246 per ml neutralized toxin-mediated inhibition of protein synthesis in Vero cells induced by 5 ng of toxin A per ml or 1.25 ng of toxin B per ml. In ligated rat ileal loops, 1 mg of GT160-246 neutralized fluid accumulation caused by 5 microg of toxin A. At doses as high as 80 mg/loop, cholestyramine provided incomplete neutralization of fluid accumulation caused by 5 microg of toxin A. GT160-246 protected 80% of the hamsters from mortality caused by infection with C. difficile, whereas cholestyramine protected only 10% of animals. Treatment of C. difficile-infected hamsters with metronidazole initially protected 100% of the hamsters from mortality, but upon removal of treatment, 80% of the hamsters had relapses and died. In contrast, removal of GT160-246 treatment did not result in disease relapse in the hamsters. GT160-246 showed no antimicrobial activity in tests with a panel of 16 aerobic bacteria and yeast and 22 anaerobic bacteria and did not interfere with the in vitro activities of most antibiotics. GT160-246 offers a novel, nonantimicrobial treatment of C. difficile disease in humans.
Volatiles Production and Lipoxygenase Gene Expression in Kiwifruit Peel and Flesh During Fruit Ripening (2009)

The relationship between lipoxygenase (LOX) pathway-derived volatiles and LOX gene expression was evaluated in kiwifruit [ Actinidia deliciosa (A. Chev.) C.F. Liang et A.R. Ferguson var. deliciosa cv. Bruno] during postharvest ripening at 20 °C. The C6 aldehydes n -hexanal and ( E )-2-hexenal were abundant in peel compared with flesh tissue and declined as kiwifruit ripened. Esters such as ethyl butanoate and methyl butanoate were lower in the peel than flesh and accumulated when the fruit underwent a climacteric rise in ethylene production. Total LOX activity was higher in the peel than in the flesh and increased as kiwifruit ripened. Expression of AdLox2 , AdLox3 , AdLox4 and AdLox6 was high in the peel, whereas AdLox1 and AdLox5 showed similar levels in the peel and flesh at the ethylene climacteric. AdLox1 and AdLox5 transcript levels increased and AdLox2 , AdLox3 , AdLox4 and AdLox6 levels decreased during postharvest fruit ripening. Principal component analysis showed that n -hexanal and ( E )-2-hexenal were grouped with LOX genes that were downregulated as kiwifruit ripened. The possible roles of LOX genes in relation to kiwifruit volatile formation during fruit ripening are discussed.
Quantifying memory effects in RF power amplifiers (2002)

This paper proposes a system-level behavioral model for RF power amplifiers (PAs), which exhibit memory effects, that is based on the parallel Wiener system. The model extraction is performed using two-tone intermodulation distortion (IMD) measurements with different tone frequency spacings and power levels. It is found that by using such a model, more accurate adjacent-channel power-ratio levels may be predicted for high PAS close to the carrier frequency. This is validated using IS-95B CDMA signals on a low-power (0.5 W) class-AB PA, and on a high-power (45 W) class-B PA. The model also provides a means to quantify memory effects in terms of a figure-of-merit that calculates the relative contribution to the IMD of the memoryless and memory portion of the PA nonlinearity. This figure-of-merit is useful in providing an estimate of the amount of correction that a memoryless predistortion system may have on PAS that exhibit memory effects.
Controversies in the management of advanced prostate cancer (1998)

For advanced prostate cancer, the main hormone treatment against which other treatments are assessed is surgical castration. It is simple, safe and effective, however it is not acceptable to all patients. Medical castration by means of luteinizing hormone-releasing hormone (LH-RH) analogues such as goserelin acetate provides an alternative to surgical castration. Diethylstilboestrol, previously the only non-surgical alternative to orchidectomy, is no longer routinely used. Castration reduces serum testosterone by around 90%, but does not affect androgen biosynthesis in the adrenal glands. Addition of an anti-androgen to medical or surgical castration blocks the effect of remaining testosterone on prostate cells and is termed combined androgen blockade (CAB). CAB has now been compared with castration alone (medical and surgical) in numerous clinical trials. Some trials show advantage of CAB over castration, whereas others report no significant difference. The author favours the view that CAB has an advantage over castration. No study has reported that CAB is less effective than castration. Of the anti-androgens which are available for use in CAB, bicalutamide may be associated with a lower incidence of side-effects compared with the other non-steroidal anti-androgens and, in common with nilutamide, has the advantage of once-daily dosing. Only one study has compared anti-androgens within CAB: bicalutamide plus LH-RH analogue and flutamide plus LH-RH analogue. At 160-week follow-up, the groups were equivalent in terms of survival and time to progression. However, bicalutamide caused significantly less diarrhoea than flutamide. Withdrawal and intermittent therapy with anti-androgens extend the range of treatment options.
Absolute Configurations of Four Resorcylic Acid Lactones, Paecilomycins J − M, by CD/TDDFT Calculations (2013)

The absolute configurations of four resorcylic acid lactones (RALs), paecilomycins J-M (1-3 and 5), were assigned by Time-Dependent Density-Functional Theory (TDDFT) calculations of their electronic circular dichroism (CD) spectra. The previously reported structure 4 for paecilomycin M was found to be incorrect and should be changed to structure 5. Analysis of structure-spectrum relationship for this group of RALs suggested that V'-shape conformations give type I CD spectra (two negative Cotton effects around 300 and 260 nm, a positive Cotton effect around 220 nm) while V-shape conformations yield type II spectra (signs of three Cotton effects were opposite to those in type I).
Implementation and performance evaluation of Indirect TCP (1997)

With the advent of small portable computers and the technological advances in wireless communications, mobile wireless computing is likely to become very popular in the near future. Wireless links are slower and less reliable compared to wired links and are prone to loss of signal due to noise and fading. Furthermore, host mobility can give rise to periods of disconnection from the fixed network. The use of existing network protocols, which were developed mainly for the high bandwidth and faster wired links, with mobile computers thus gives rise to unique performance problems arising from host mobility and due to the characteristics of wireless medium. Indirect protocols can isolate mobility and wireless related problems using mobility support routers (MSRs) as intermediaries, which also provide backward compatibility with fixed network protocols. We present the implementation and performance evaluation of I-TCP, which is an indirect transport layer protocol for mobile wireless environments. Throughput comparison with regular (BSD) TCP shows that I-TCP performs significantly better in a wide range of conditions related to wireless losses and host mobility. We also describe the implementation and performance of I-TCP handoffs.
suPAR: The Molecular Crystal Ball (2009)

soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR I-III , suPAR II-III and suPAR I which show different properties due to structural differences. Studies suggest that full-length suPAR is a regulator of uPAR/uPA by acting as uPA-scavenger, whereas the cleaved suPAR II-III act as a chemotactic agent promoting the immune response via the SRSRY sequence in the linker-region. This review focus on the various suPAR fragments and their involvement in inflammation and pathogenic processes. We focus on the molecular mechanisms of the suPAR fragments and the link to the inflammatory process, as this could lead to medical applications in infectious and pathological conditions.
DCP‐LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP‐1 inhibition (2009)

The linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) activated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) by inhibiting protein phosphatase-1 (PP-1). DCP-LA induced a transient huge facilitation of synaptic transmission monitored from the CA1 region of rat hippocampal slices, which was largely inhibited by the CaMKII inhibitor KN-93. DCP-LA potentiated kainate-evoked whole-cell membrane currents for Xenopus oocytes expressing alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors composed of the GluR1, GluR3, GluR1/GluR2, GluR1/GluR3, and GluR1/GluR2/GluR3 subunits, and the potentiation was significantly inhibited by KN-93. A similar potentiation was still found with mutant GluR1 (S831A) receptor lacking CaMKII phosphorylation site. The GluR1 and GluR2 subunits formed AMPA receptors in the rat hippocampus, and DCP-LA increased expression of both the subunits on the plasma membrane. The DCP-LA action was blocked by KN-93 and the exocytosis inhibitor botulinum toxin type A, but not by the endocytosis inhibitor phenylarsine oxide. DCP-LA, thus, appears to activate CaMKII through PP-1 inhibition, that stimulates AMPA receptor exocytosis to increase expression of the receptors on the plasma membrane, responsible for potentiate AMPA receptor responses and facilitation of hippocampal synaptic transmission.
Coexpression of c-erbB 1-4 receptor proteins in human glioblastomas. An immunohistochemical study. (2007)

Studies support involvement of the erbB/HER (human epidermal growth factor receptor) family, comprising the c-erbB-1/2/3/4 receptor proteins, in the tumourigenesis of human gliomas, raising their potential role in diagnostic and therapeutic approaches to these tumours. Reliable detection systems for these molecules in glioma tissue are therefore needed. Formalin-fixed and paraffin-embedded sections from twenty-one human glioblastomas were investigated by standard immunohistochemical procedures for expression of c-erbB-1/2/3/4 receptor proteins using commercial antibodies. All the antibodies used worked satisfactorily on paraffin-sections. For EGFR (epidermal growth factor receptor) two antibodies reactive against the external and internal domain were used. The first revealed positive immunoreactivity in 13 of 21 tumours (62 %), whereas all were positive with the latter. All glioblastomas were negative for the mutated variant of EGFR (i.e. EGFRvIII). Nine of 21 tumours (43 %) were immunoreactive for c-erbB-2, 19 of 20 tumours (95 %) for c-erbB-3, and 21 of 21 for c-erbB-4. Kaplan-Meier plots as a function of growth factor receptor expression did not show any significant association with survival among the glioblastoma patients. In conclusion, immunohistochemistry is well suited for detection of erb receptor proteins in glioblastoma tissue and demonstrated abundant and simultaneous immunoreactivity of these receptors.
Multi‐step processing of procathepsin L in vitro (1994)

The proteolytic processes involved in the conversion of procathepsin L to cathepsin L on a negatively charged surface, dextran sulfate, were studied. Upon incubation for 30 min at 37 degrees C, pH 5.5 with dextran-sulfate and dithiothreitol, purified procathepsin L showed maximal activation and, correspondingly, the complete conversion to the 30 kDa, single chain mature form of enzyme was observed. In contrast, incubation under the same conditions on ice rather than at 37 degrees C for 30 or 60 min resulted in partial proteolysis to produce a 31 kDa form without a significant increase in activity. Amino terminal amino acid sequence analyses showed that the 30 kDa form obtained by incubation at 37 degrees C corresponds to the purified form of mature cathepsin L with a 2 amino acid extension at the amino terminal, and that the 31 kDa form generated by incubation on ice possesses a 6 amino acid amino terminal extension, suggesting that the activation and processing of procathepsin L are different processes, and that 4 amino acid residues (Glu-Pro-Leu-Met) at the carboxyterminal in the propeptide function to prevent the activation of processed cathepsin L.
Multiple gene evidence for expansion of extant penguins out of Antarctica due to global cooling (2005)

Classic problems in historical biogeography are where did penguins originate, and why are such mobile birds restricted to the Southern Hemisphere? Competing hypotheses posit they arose in tropical-warm temperate waters, species-diverse cool temperate regions, or in Gondwanaland approximately 100 mya when it was further north. To test these hypotheses we constructed a strongly supported phylogeny of extant penguins from 5851 bp of mitochondrial and nuclear DNA. Using Bayesian inference of ancestral areas we show that an Antarctic origin of extant taxa is highly likely, and that more derived taxa occur in lower latitudes. Molecular dating estimated penguins originated about 71 million years ago in Gondwanaland when it was further south and cooler. Moreover, extant taxa are inferred to have originated in the Eocene, coincident with the extinction of the larger-bodied fossil taxa as global climate cooled. We hypothesize that, as Antarctica became ice-encrusted, modern penguins expanded via the circumpolar current to oceanic islands within the Antarctic Convergence, and later to the southern continents. Thus, global cooling has had a major impact on penguin evolution, as it has on vertebrates generally. Penguins only reached cooler tropical waters in the Galapagos about 4 mya, and have not crossed the equatorial thermal barrier.
Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits (2000)

The yeast CCR4-NOT protein complex is a global regulator of RNA polymerase II transcription. It is comprised of yeast NOT1 to NOT5, yeast CCR4 and additional proteins like yeast CAF1. Here we report the isolation of cDNAs encoding human NOT2, NOT3, NOT4 and a CAF1-like factor, CALIF. Analysis of their mRNA levels in different human tissues reveals a common ubiquitous expression pattern. A multitude of two-hybrid interactions among the human cDNAs suggest that their encoded proteins also form a complex in mammalian cells. Functional conservation of these proteins throughout evolution is supported by the observation that the isolated human NOT3 and NOT4 cDNAs can partially com-plement corresponding not mutations in yeast. Interestingly, human CALIF is highly homologous to, although clearly different from, a recently described human CAF1 protein. Conserved interactions of this factor with both NOT and CCR4 proteins and co-immunoprecipitation experiments suggest that CALIF is a bona fide component of the human CCR4-NOT complex.
Thoracoscopic versus Open Repair of Congenital Diaphragmatic Hernia: A Systematic Review and Meta-Analysis (2019)

Congenital diaphragmatic hernia is a malformation characterized by the defect of diaphragm development, occurring in approximately 1 in 2500-4000 live births
Large-scale cDNA transfection screening for genes related to cancer development and progression (2004)

A large-scale assay was performed by transfecting 29,910 individual cDNA clones derived from human placenta, fetus, and normal liver tissues into human hepatoma cells and 22,926 cDNA clones into mouse NIH 3T3 cells. Based on the results of colony formation in hepatoma cells and foci formation in NIH 3T3 cells, 3,806 cDNA species (8,237 clones) were found to possess the ability of either stimulating or inhibiting cell growth. Among them, 2,836 (6,958 clones) were known genes, 372 (384 clones) were previously unrecognized genes, and 598 (895 clones) were unigenes of uncharacterized structure and function. A comprehensive analysis of the genes and the potential mechanisms for their involvement in the regulation of cell growth is provided. The genes were classified into four categories: I, genes related to the basic cellular mechanism for growth and survival; II, genes related to the cellular microenvironment; III, genes related to host-cell systemic regulation; and IV, genes of miscellaneous function. The extensive growth-regulatory activity of genes with such highly diversified functions suggests that cancer may be related to multiple levels of cellular and systemic controls. The present assay provides a direct genomewide functional screening method. It offers a better understanding of the basic machinery of oncogenesis, including previously undescribed systemic regulatory mechanisms, and also provides a tool for gene discovery with potential clinical applications.
LOX-1, OxLDL, and Atherosclerosis (2013)

Oxidized low-density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation and progression by several mechanisms, including the induction of endothelial cell activation and dysfunction, macrophage foam cell formation, and smooth muscle cell migration and proliferation. Vascular wall cells express on their surface several scavenger receptors that mediate the cellular effects of OxLDL. The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the main OxLDL receptor of endothelial cells, and it is expressed also in macrophages and smooth muscle cells. LOX-1 is almost undetectable under physiological conditions, but it is upregulated following the exposure to several proinflammatory and proatherogenic stimuli and can be detected in animal and human atherosclerotic lesions. The key contribution of LOX-1 to the atherogenic process has been confirmed in animal models; LOX-1 knockout mice exhibit reduced intima thickness and inflammation and increased expression of protective factors; on the contrary, LOX-1 overexpressing mice present an accelerated atherosclerotic lesion formation which is associated with increased inflammation. In humans, LOX-1 gene polymorphisms were associated with increased susceptibility to myocardial infarction. Inhibition of the LOX-1 receptor with chemicals or antisense nucleotides is currently being investigated and represents an emerging approach for controlling OxLDL-LOX-1 mediated proatherogenic effects.
Outcome, Cost Analysis, and Long-term Follow-up in Preterm Infants with Massive Grade IV Germinal Matrix Hemorrhage and Progressive Hydrocephalus (1997)

As we have previously reported, logistic regression analysis determined that grade of hemorrhage was the only significant predictor of cognitive and motor outcomes. Most premature neonates with massive intracranial hemorrhages do not survive. The outcomes in those who do is very poor and the cost so high that we suggest that until therapeutic intervention exhibits efficacy, the consideration of withdrawal of life support should be presented as an option to the parents of these unfortunate children.