gebhart/patrepeval huggingface dataset:
Hyperbaric oxygen combined with nicardipine administration accelerates neurologic recovery after cerebral ischemia in a canine model (1994)

Combined therapy, using hyperbaric oxygenation with nicardipine administration, given after 15 mins of complete global cerebral ischemia, accelerates neurologic recovery in dogs.
Acid β‐glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α‐synuclein processing (2011)

Our results demonstrate that GBA mutants promote SNCA accumulation in a dose- and time-dependent manner, thereby identifying a biochemical link between GBA1 mutation carrier status and increased synucleinopathy risk. In cell culture models, this gain of toxic function effect can be mitigated by rapamycin. Loss in GCase activity did not immediately raise SNCA concentrations, but first led to neuronal ubiquitinopathy and axonal spheroids, a phenotype shared with other lysosomal storage disorders.
A compression technique for large statistical data-bases (1981)

In this paper we explore the compression of large statistical databases and propose techniques for organizing the compressed data, such that the time required to access the data is logarithmic. Our techniques are variations of run-length encoding, in which modified run-lengths for the series are extracted from the data stream and stored in a header, which is used to form the base level of a B-tree index into the database. The run-lengths are cumulative, and therefore the access time of the data is logarithmic in the size of the header. We discuss the details of the compression scheme and its implementation, present several special cases and give an analysis of the relative performance of the various versions.
Diffusion of Tin into Silicon (1968)

Diffusion of a neutral impurity (tin) into silicon in the presence or absence of acceptor- or donor-type impurities, such as boron or phosphorus, has been investigated through neutron-activation analysis. The diffusivity of tin alone in near-intrinsic silicon is found to be D0=32 exp(−98 000/RT)cm2·sec−1. In the simultaneous diffusion of tin and phosphorus, the diffusivity of tin is enhanced. It is found to agree well with the calculated increase of diffusivity, based on the model of increase of total equilibrium lattice vacancy concentration with donor concentration. However, in the simultaneous diffusion of tin and boron, the diffusivity of tin (due to the presence of boron) is found to be approximately the same as that without the boron. Although the acceptor doping is expected to reduce the tin diffusivity slightly, this effect cannot be ascertained with experimental accuracy.
Interactions Between Tetrahydrothiophene (THT) and Silver Species in AgNa-Y (2010)

We studied the interaction between tetrahydrothiophene (THT), which is one of sulfur odorants in a pipeline natural gas, and AgNa-Y zeolites, which can be obtained via Ag+ exchange with Na+ of Na-Y and used for the adsorptive removal of THT at ambient temperature and atmospheric pressure, with a temperature-programmed desorption (TPD), a temperature-programmed reduction with H2 (H2-TPR), a transmission electron microscopy (TEM) with an energy dispersive X-ray spectroscopy (EDX) and an X-ray absorption fine structure (XAFS). The presence of the metallic Ag and the Ag+ in the fresh AgNa-Y can be supported with a TEM and an XAFS analysis. The fraction of metallic Ag in silver species increased with increasing the pretreatment temperature. The formation of Ag-S bond with concomitant decreasing the interaction between Ag+ and oxygen in the lattice as well as the interaction of Ag-Ag in the metallic Ag can be observed during the adsorption of THT at ambient temperature. This can explain why there is no noticeable difference in the adsorption capacity in between Ag+ -dominant AgNa-Y and Ag0-rich AgNa-Y. This Ag-S bond was transformed into the Ag-Ag bond during the heat treatment in an inert gas above 673 K. However, the fresh chemical and electronic state of Ag can be recovered after the heat treatment in air above 673 K.
Model for a ring transducer with inactive segments (1976)

The equation of motion and the equivalent circuit for a segmented ring transducer which incorporates inactive segments is developed. Design considerations are discussed, and it is shown that, although the motion at resonance is dependent on the inactive segments, well below resonance the motion is independent of these segments. Subject Classification: [43]85.52; [43]30.85.
Comparative evaluation of chemiluminescent DNA probe assays and exoantigen tests for rapid identification of Blastomyces dermatitidis and Coccidioides immitis (1994)

Chemiluminescent DNA probe (Accuprobe) assays developed by Gen-Probe, Inc. (San Diego, Calif.), for the rapid identification of Blastomyces dermatitidis and Coccidioides immitis were evaluated and compared with the exoantigen test by using 74 mycelial cultures of B. dermatitidis and 72 mycelial cultures of C. immitis. Seventeen isolates of the dimorphic pathogen Paracoccidioides brasiliensis were included because of their gross morphologic and antigenic relatedness to B. dermatitidis. The heterologous fungi, namely, species of Chrysosporium, which are often confused with B. dermatitidis, and species of Malbranchea, which morphologically resemble C. immitis, were tested. All 74 of the B. dermatitidis mycelial isolates were correctly identified by the Accuprobe assay for B. dermatitidis within 2 h. However, the B. dermatitidis probe cross-hybridized with rRNA extracts of 10 of the 17 P. brasiliensis isolates, misidentifying them as B. dermatitidis. All 72 of the C. immitis isolates were identified correctly with the C. immitis probe. None of the other heterologous fungi belonging to Chrysosporium spp., Malbranchea spp., Onychocola canadensis, and Geotrichum sp. were cross-reactive with the B. dermatitidis and C. immitis probes. The exoantigen tests specifically identified 74 B. dermatitidis, 72 C. immitis, and 17 P. brasiliensis isolates within 48 to 72 h and differentiated the related heterologous fungi from the three dimorphic fungal pathogens.
Ranging of UHF RFID Tag Using Stepped Frequency Read-Out (2010)

This paper presents a phase-based method for obtaining the distance of an RFID tag with unknown properties. The tag's response is measured by the reader at several discrete frequencies at the threshold power of the tag. The dispersive properties of the modulated reflection coefficient of the tag are estimated from the measured power sensitivity and their effect is compensated in the distance estimation. The method is derived using a simple theoretical model for the tag and the performance of the method is experimentally verified at 860 MHz.
An Integrated Algorithm for Text Recognition: Comparison with a Cascaded Algorithm (1983)

The use of diverse knowledge sources in text recognition and in correction of letter substitution errors in words of text is considered. Three knowledge sources are defined: channel characteristics as probabilities that observed letters are corruptions of other letters, bottom-up context as letter conditional probabilities (when the previous letters of the word are known), and top-down context as a lexicon. Two algorithms, one based on integrating the knowledge sources in a single step and the other based on sequentially cascading bottom-up and top-down processes, are compared in terms of computational/storage requirements and results of experimentation.
Hematopoietic factor production by a cell line (TC-1) derived from adherent murine marrow cells (1985)

An adherent cell line, termed TC-1, has been isolated from long-term liquid culture of murine marrow cells by repeated exposure of the adherent cells to 0.1% trypsin. This is an alkaline phosphatase- positive cell line showing variable staining with acid phosphatase and alpha-naphthyl acetate esterase. On electron microscopy, the cells have moderate amounts of rough endoplasmic reticulum and variable numbers of polyribosomes. Some cells contain large clusters of laked glycogen particles. Intermediate junctions are present between some cells. Conditioned medium from this cell line produced from 384 to 638 units of CSF-1 per milliliter by radioimmunoassay and a CSF-1-dependent synergistic activity, which stimulates giant macrophage colony formation of marrow cells in soft agar. The conditioned medium also stimulates 3H-TdR incorporation by marrow cells in liquid culture and induces secondary adherent cell lines. The growth factor(s) produced by the TC-1 stromal cell line may be important in the regulation of early stages of hematopoietic differentiation. Two subclones, TC-1-C-11 and TC-1-C-3, have been isolated from passage 25 of the TC-1 cells by a penicylinder separation technique. The TC-1-C-11 is phenotypically like the parent TC-1 line and produces macrophage growth factors. The TC-1-C- 3 grows as an epithelioid monolayer with visible junctions among adjacent cells under phase contrast microscopy. This subclone produces retrovirus and is capable of providing anchorage support for hematopoietic stem cells. The TC-1 cell line and its subclones may provide models for the control of early stem cell proliferation and differentiation.
Naratriptan is effective and well tolerated in the acute treatment of migraine (1997)

The efficacy and tolerability of naratriptan tablets (2.5 mg, 1 mg, and 0.25 mg) compared with placebo in the acute treatment of migraine were evaluated in a randomized, double-blind, four-period crossover study. Five hundred eighty-six assessable patients received naratriptan 2.5 mg, 595 received 1 mg, 591 received 0.25 mg, 602 received placebo. Headache relief (moderate or severe pain reduced to mild or none) 4 hours postdose was reported in 68% of patients after treatment with naratriptan 2.5 mg compared with 57% after 1 mg, 39% after 0.25 mg, and 33% after placebo (p < 0.001 naratriptan 2.5 mg and 1 mg versus placebo and 1 mg and 2.5 mg versus 0.25 mg). Headache relief was maintained 8, 12, and 24 hours postdose with no use of rescue medication or a second dose of study medication by significantly (p < 0.001) greater percentages of patients after treatment with naratriptan 2.5 mg or 1 mg compared with naratriptan 0.25 mg or placebo. Naratriptan was also more effective than placebo in reducing clinical disability and the incidences of nausea, photophobia, and phonophobia. The overall incidence of adverse events and the incidences of specific adverse events did not differ in the naratriptan groups compared with placebo. No clinically relevant changes in ECG, blood pressure, or laboratory findings were reported. These data demonstrate that naratriptan is effective and well tolerated for the acute treatment of migraine. The 2.5-mg dose was associated with superior efficacy, whereas its adverse event profile was similar to that of placebo.
Off-resonance transformer charging for 250-kV water blumlein (1979)

An off-resonance transformer for charging a 250-kV Blumlein system provides a viable alternative to other charging schemes by permitting the use of conventional thyratrons. Such a transformer must have reliability, a reasonable voltage stepup, and a nonreversing primary current. This paper presents the analysis, design, and performance data for such a transformer. The strong interrelationship between transformer design and Blumlein requirements necessitates that Blumlein description and design criterion be briefly presented prior to transformer design such that transformer load requirements be defined.
Preparing for a change: A planning framework for business process reengineering (1997)

Business Process Reeingineering (BPR) projects offer organizations a means for improving their business processes. The high failure rate associated with BPR projects points to the need to have detailed plans designed prior to introducing change. This article provides a planning framework modeled on Lewin's three-stage change model. The framework incorporates both social and technical aspects of the project. The framework presented is a comprehensive planning process. It presents a guideline for establishing a solid foundation prior to implementing change. Although good planning cannot guarantee success, success without planning is impossible.
Predictive Updating Methods with Application to Bayesian Classification (1996)

SUMMARY We propose algorithms based on random draws from predictive distributions of unknown quantities (missing values, for instance). This procedure can either be iterative, which is a special variation of the Gibbs sampler, or be sequential, which is a variation of sequential imputation. In the latter case one can update the posterior distribution with new observations easily. The methods proposed have intuitive statistical implications and can be generalized to accommodate other Bayesian-like procedures. We display some applications of the method in connection with the Bayesian bootstrap, classification, hierarchical models and selection of variables. In particular, as an application of the method, we present a unified treatment of switching regression models driven by a general binary process, and we develop a Bayesian testing procedure. Some simulations and a real example are used to illustrate the methods proposed.
The Trp Cage:  Folding Kinetics and Unfolded State Topology via Molecular Dynamics Simulations (2002)

Using over 75 mus of molecular dynamics simulation, we have generated several thousand folding simulations of the 20-residue Trp cage at experimental temperature and solvent viscosity. A total of 116 independent folding simulations reach RMSDcalpha values below 3 A RMSDcalpha, some as close as 1.4 A RMSDcalpha. We estimate a folding time of 5.5+/-3.5 mus, a rate that is in reasonable agreement with experimental kinetics. Finally, we characterize both the folded and unfolded ensemble under native conditions and note that the average topology of the unfolded ensemble is very similar to the topology of the native state.
Terahertz radiation from an InAs surface due to lateral photocurrent transients (2015)

We report on terahertz (THz) emission from a (111)-cut InAs crystal in the reflection and transmission directions, excited by femtosecond optical pulses in the direction of its surface normal. THz pulse amplitudes emitted from the crystal surface in this case were only ~20% smaller than for optimal photoexcitation at a 45° angle. This observation evidences that THz emission from InAs is caused by lateral photocurrent transients appearing due to a crystal anisotropy rather than directly by the photo-Dember effect, which creates fast changing electric polarization perpendicular to the surface. Such a simple geometry of the photoexcitation could greatly enhance the fields of surface THz emitter applications.
Adsorption of Arsenate onto Ferrihydrite from Aqueous Solution:  Influence of Media (Sulfate vs Nitrate), Added Gypsum, and pH Alteration (2005)

Mineral processing effluents generated in hydrometallurgical industrial operations are sulfate based; hence it is of interest to investigate the effect sulfate matrix solution ("sulfate media") has on arsenate adsorption onto ferrihydrite. In this work, in particular, the influence of media (SO4(2-) vs NO3-), added gypsum, and pH alteration on the adsorption of arsenate onto ferrihydrite has been studied. The ferrihydrite precipitated from sulfate solution incorporated a significant amount of sulfate ions and showed a much higher adsorption capacityfor arsenate compared to nitrateferrihydrite at pH 3-8 and initial Fe/As molar ratios of 2, 4, and 8. Adsorption of arsenate onto sulfate-ferrihydrite involved ligand exchange with SO4(2-) ions that were found to be more easily exchangeable with increasing pH. Added gypsum to the adsorption system significantly enhanced the uptake of arsenate by ferrihydrite at pH 8. Equilibration treatment at acidic pH and addition of gypsum markedly improved the stability of adsorbed arsenate on ferrihydrite when pH was elevated. Comparison of arsenate adsorption onto ferrihydrite to coprecipitation of arsenate with iron(III) showed the latter process to lead to higher arsenic removal.
[The T cell activation from peripheral blood of patients with herpetic keratitis following in vitro activation]. (1999)

The ability of T cells activation decreases in cases with HSK following in vitro activation. The lymphocytes in patients with HUK shows much lower activation than those cases with HUK.
Abstract 197: The KRAB-containing zinc finger protein ZNF545 is a functional tumor suppressor exerting proapoptotic and antiproliferation abilities with frequent epigenetic inactivation in multiple carcinomas (2010)

Abstract Epigenetic silencing of tumor suppressor gene is frequently involved in tumor development. Some zinc finger proteins (ZFPs) involved in tumorigenesis are down-regulated through CpG methylation in multiple carcinomas. Here, through genome wide-screening, we identified a novel KRAB domain-containing zinc finger protein (KRAB-ZFP), ZNF545, downregulated in multiple tumor cell lines including nasopharyngeal, esophageal, colon, stomach, liver, kidney, breast, cervix, and prostate carcinomas, in contrast to its broad expression in normal tissues. The promoter of ZNF545 contains a typical CpG island and is frequently methylated in multiple carcinoma cell lines. Transcriptional silencing of ZNF545 could be reversed by pharmacologic demethylation or genetic demethylation, indicating a direct epigenetic silencing mechanism. ZNF545 was also frequently methylated in primary tumors of NPC and ESCC, but less frequently in normal epithelial tissues and paired surgical marginal normal tissues. ZNF545 was found to be a transcriptional repressor when fused to Gal4-binding domain, as determined by the luciferase assay. Ectopic expression of ZNF545 in silenced cancer cell lines significantly inhibited their colony formation, proliferation and induced apoptosis, indicating that ZNF545 can function as a tumor suppressor. ZNF545 also can inhibit the activity of NF-KappaB and AP-1, which play an important role in tumorigenesis. We further found that ZNF545 was located in the nucleus and sequestered in the nucleolus in some cells. ZNF545 could co-localize with KAP1 and heterochromatin protein, so we proposed that ZNF545 could inhibit tumorigenesis, at least partially through downregulating the transcription of target genes, or regulating nucleolus function such as ribosome biogenesis. The tumor specific-silencing of ZNF545 could serve as an epigenetic biomarker for common cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 197.
Towards Improved Human Action Recognition Using Convolutional Neural Networks and Multimodal Fusion of Depth and Inertial Sensor Data (2018)

This paper attempts at improving the accuracy of Human Action Recognition (HAR) by fusion of depth and inertial sensor data. Firstly, we transform the depth data into Sequential Front view Images(SFI) and fine-tune the pre-trained AlexNet on these images. Then, inertial data is converted into Signal Images (SI) and another convolutional neural network (CNN) is trained on these images. Finally, learned features are extracted from both CNN, fused together to make a shared feature layer, and these features are fed to the classifier. We experiment with two classifiers, namely Support Vector Machines (SVM) and softmax classifier and compare their performances. The recognition accuracies of each modality, depth data alone and sensor data alone are also calculated and compared with fusion based accuracies to highlight the fact that fusion of modalities yields better results than individual modalities. Experimental results on UTD-MHAD and Kinect 2D datasets show that proposed method achieves state of the art results when compared to other recently proposed visual-inertial action recognition methods.
Solution-Based Straight and Branched CdSe Nanowires (2004)

Confined straight and branched CdSe nanowires (NWs) are synthesized using a solution-based approach which leverages advances in the synthesis of colloidal CdSe quantum dots (QDs) with incipient approaches for the seeded (solution) synthesis of semiconductor NWs. The resulting straight and branched NWs have typical diameters below 10 nm with accompanying lengths between 1 and 10 μm. In the case of branched NWs, tripod, v-shaped, and y-shaped morphologies are observed. Variations in this preparation lead to higher order structures with multiple arms. The branching transition is discussed, and a possible mechanism based upon geminate NW nucleation is proposed. Such solution-grown straight, branched, and higher-order NWs exhibit potentially interesting optical, electrical, and transport properties due to their narrow radii below the corresponding bulk exciton Bohr radius of CdSe. Furthermore, this transition from straight to branched morphologies opens up avenues for investigating not only size- but also shape-dependent optical/electrical properties of one-dimensional (1D) and quasi-1D materials.
Differences in the cerebrovascular anatomy of C57Black/6 and SV129 mice (1998)

The vascular architecture of the brain of C57Black/6 and SV129 mice was studied following microvascular injection of carbon black stained latex. The dorsal brain surface was photographed to determine the number, diameter, and position of pial anastomotic vessels between the middle and anterior cerebral arteries. The mean number and diameter of anastomoses were not significantly different, but the line of anastomoses interconnecting the half way points of anastomotic vessels was located significantly closer to the midline in C57Black/6 mice, demonstrating that the middle cerebral artery had a larger vascular supplying territory than in SV129 mice. This explains the larger infarct volume previously reported in C57Black/6 mice, and raises concerns about the use of C57Black/6 and SV129 mice as parent strains for genetically modified animals in stroke research.
Nicotine and Carcinogen Exposure with Smoking of Progressively Reduced Nicotine Content Cigarette (2007)

Our findings with reduced nicotine content cigarettes differ from those of commercial low yields for which compensatory smoking for lower nicotine delivery is substantial. Our data suggest that the degree of nicotine dependence of smokers can be lowered without increasing their exposure to tobacco smoke toxins. Gradual reduction of nicotine content of cigarettes seems to be feasible and should be further evaluated as a national tobacco regulatory strategy.
Reevaluation of the Role of <i>HWP1</i> in Systemic Candidiasis by Use of <i>Candida albicans</i> Strains with Selectable Marker <i>URA3</i> Targeted to the <i>ENO1</i> Locus (2002)

Previous evaluation of HWP1 in systemic candidiasis in CBA/J mice was done with Candida albicans strains with differing genetic locations of URA3 as a result of Ura-blaster mutagenesis. In this study, the presence of HWP1 and the location of URA3 contributed to the severity of murine systemic candidiasis in BALB/c mice.
[Therapeutic agents for disorders of bone and calcium metabolism--Parathyroid hormone in weekly subcutaneous injection]. (2007)

The parathyroid hormone (PTH) that is marketed outside Japan is for daily administration. It has been proven to increase bone mass and prevent fractures, and the effects are very strong. However, data suggest that daily administration of PTH increases bone resorption. By contrast, weekly administration of PTH, which is being developed in Japan, actually decreases bone resorption, and data suggest that this regimen maintains a good balance between bone formation (predominant) and bone resorption. Furthermore, it has been reported that weekly administration of PTH increases bone mass as much as every day administration of PTH, and as such, weekly administration of PTH has the potential to be a useful regimen with characteristics that are different from those of daily administration of PTH.