gebhart/patrepeval huggingface dataset:
EVpedia: an integrated database of high‐throughput data for systemic analyses of extracellular vesicles (2013)

Secretion of extracellular vesicles is a general cellular activity that spans the range from simple unicellular organisms (e.g. archaea; Gram-positive and Gram-negative bacteria) to complex multicellular ones, suggesting that this extracellular vesicle-mediated communication is evolutionarily conserved. Extracellular vesicles are spherical bilayered proteolipids with a mean diameter of 20-1,000 nm, which are known to contain various bioactive molecules including proteins, lipids, and nucleic acids. Here, we present EVpedia, which is an integrated database of high-throughput datasets from prokaryotic and eukaryotic extracellular vesicles. EVpedia provides high-throughput datasets of vesicular components (proteins, mRNAs, miRNAs, and lipids) present on prokaryotic, non-mammalian eukaryotic, and mammalian extracellular vesicles. In addition, EVpedia also provides an array of tools, such as the search and browse of vesicular components, Gene Ontology enrichment analysis, network analysis of vesicular proteins and mRNAs, and a comparison of vesicular datasets by ortholog identification. Moreover, publications on extracellular vesicle studies are listed in the database. This free web-based database of EVpedia (http://evpedia.info) might serve as a fundamental repository to stimulate the advancement of extracellular vesicle studies and to elucidate the novel functions of these complex extracellular organelles.
Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury (2012)

Acute pancreatitis is a major health burden for which there are currently no targeted therapies. Premature activation of digestive proenzymes, or zymogens, within the pancreatic acinar cell is an early and critical event in this disease. A high-amplitude, sustained rise in acinar cell Ca(2+) is required for zymogen activation. We previously showed in a cholecystokinin-induced pancreatitis model that a potential target of this aberrant Ca(2+) signaling is the Ca(2+)-activated phosphatase calcineurin (Cn). However, in this study, we examined the role of Cn on both zymogen activation and injury, in the clinically relevant condition of neurogenic stimulation (by giving the acetylcholine analog carbachol) using three different Cn inhibitors or Cn-deficient acinar cells. In freshly isolated mouse acinar cells, pretreatment with FK506, calcineurin inhibitory peptide (CiP), or cyclosporine (CsA) blocked intra-acinar zymogen activation (n = 3; P < 0.05). The Cn inhibitors also reduced leakage of lactate dehydrogenase (LDH) by 79%, 62%, and 63%, respectively (n = 3; P < 0.05). Of the various Cn isoforms, the β-isoform of the catalytic A subunit (CnAβ) was strongly expressed in mouse acinar cells. For this reason, we obtained acinar cells from CnAβ-deficient mice (CnAβ-/-) and observed an 84% and 50% reduction in trypsin and chymotrypsin activation, respectively, compared with wild-type controls (n = 3; P < 0.05). LDH release in the CnAβ-deficient cells was reduced by 50% (n = 2; P < 0.05). The CnAβ-deficient cells were also protected against zymogen activation and cell injury induced by the cholecystokinin analog caerulein. Importantly, amylase secretion was generally not affected by either the Cn inhibitors or Cn deficiency. These data provide both pharmacological and genetic evidence that implicates Cn in intra-acinar zymogen activation and cell injury during pancreatitis.
Enhanced Signal-to-Background Ratios in Voltammetric Measurements Made at Diamond Thin-Film Electrochemical Interfaces (1996)

Large signal-to-background (S/B) ratios for the Fe(CN)(6)(3)(-)(/4)(-) and IrCl(6)(2)(-)(/3)(-) redox couples in KCl have been observed in cyclic voltammetric measurements made at a conductive diamond thin-film electrode without any conventional surface pretreatment. The S/B ratios were a factor of ∼16 and 8 larger at diamond than at freshly polished glassy carbon (GC) for Fe(CN)(6)(3)(-)(/4)(-) and IrCl(6)(2)(-)(/3)(-), respectively. The polycrystalline diamond film, grown on a p-Si(100) substrate, possessed significant cubic {100} faceting, as evidenced by AFM images, and was of high quality, as indicated by Raman spectroscopy. The high degree of electrochemical activity without surface pretreatment, the enhanced S/B ratios, and the excellent response stability demonstrate that diamond might be an attractive new electrode material for electroanalysis.
Cmos vlsi implementation of a low-power logarithmic converter (2003)

We present a unique 32-bit binary-to-binary logarithm converter including its CMOS VLSI implementation. The converter is implemented using combinational logic only and it calculates a logarithm approximation in a single clock cycle. Unlike other complex logarithm correcting algorithms, three unique algorithms are developed and implemented with low-power and fast circuits that reduce the maximum percent errors that result from binary-to-binary logarithm conversion to 0.9299 percent, 0.4314 percent, and 0.1538 percent. Fast 4, 16, and 32-bit leading-one detector circuits are designed to obtain the leading-one position of an input binary word. A 32-word/spl times/5-bit MOS ROM is used to provide 5-bit integers based on the corresponding leading-one position. Both converter area and speed have been considered in the design approach, resulting in the use of a very efficient 32-bit logarithmic shifter in the 32-bit logarithmic converter. The converter is implemented using 0.6/spl mu/m CMOS technology, and it requires 1,600/spl lambda//spl times/2,800/spl lambda/ of chip area. Simulations of the CMOS design for the 32-bit logarithmic converter, operating at V/sub DD/ equal to 5 volts, run at 55 MHz, and the converter consumes 20 milliwatts.
COGNITIVE FUNCTION-A COMPARISON BETWEEN ELDERLY NON DIABETIC AND DIABETIC SUBJECTS. (2016)

Introduction:- Increase in life expectancy and fall in death rate has led to rise in the proportion of the elderly in the community all over the world. The ageing population is facing a double epidemic
A high performance biometric signal and image processing method to reveal blood perfusion towards 3D oxygen saturation mapping (2014)

Non-contact imaging photoplethysmography (PPG) is a recent development in the field of physiological data acquisition, currently undergoing a large amount of research to characterize and define the range of its capabilities. Contact-based PPG techniques have been broadly used in clinical scenarios for a number of years to obtain direct information about the degree of oxygen saturation for patients. With the advent of imaging techniques, there is strong potential to enable access to additional information such as multi-dimensional blood perfusion and saturation mapping. The further development of effective opto-physiological monitoring techniques is dependent upon novel modelling techniques coupled with improved sensor design and effective signal processing methodologies. The biometric signal and imaging processing platform (bSIPP) provides a comprehensive set of features for extraction and analysis of recorded iPPG data, enabling direct comparison with other biomedical diagnostic tools such as ECG and EEG. Additionally, utilizing information about the nature of tissue structure has enabled the generation of an engineering model describing the behaviour of light during its travel through the biological tissue. This enables the estimation of the relative oxygen saturation and blood perfusion in different layers of the tissue to be calculated, which has the potential to be a useful diagnostic tool.
A Novel Noninvasive Measurement Technique for Analyzing the Pressure Pulse Waveform of the Radial Artery (2007)

Previous noninvasive measurements of the pulse waveform of the radial artery have not employed standard positioning procedures. Here, we propose a new noninvasive measuring apparatus that has a two-axis mechanism and employs a standard positioning procedure for detecting the optimal site for accurately measuring the pressure pulse waveform (PPW). A modified sensor was designed to simultaneously measure the arterial diameter changed waveform (ADCW) and PPW. Considering the artery as a cylinder, the measured waveform would be distorted if the sensor were not at the middle of arterial width. Moreover, a blood vessel is elastic, and its compliance changes with the transmural pressure, being maximal when the transmural pressure is equal to zero. The sensor should detect the PPW with the lowest possible distortion and, hence, an analysis of the vascular geometry and an arterial model were used to design a standard positioning procedure based on the ADCW for the X and Z axes. In order to verify the resolution of the X axis scanning procedure, the echo method was used to measure the radial artery outer diameter in ten healthy subjects. The difference between the scanning width and the actual arterial diameter was 0.36 +/- 0.23 mm (mean +/- SD). Finally, the PPW as measured at the optimal position was used to diagnose myocardial ischemia symptoms in 60 elderly subjects whose chief complaint was chest pain, with the exercise electrocardiogram being used as a reference to compare between individuals with and without myocardial ischemia. The PPW analysis used the harmonic components in the frequency domain. We found that the fourth harmonic of the Fourier series differed significantly between the groups (p = 0.0039), which is consistent with previous studies. The results indicate that our noninvasive measurement apparatus is very suitable for analyzing the PPW of the radial artery.
Watch-boxes (1898)

Watch-boxes Get access John T. Page John T. Page 1West Haddon, Northamptonshire Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s9-I, Issue 26, 25 June 1898, Page 514, https://doi.org/10.1093/nq/s9-I.26.514c Published: 25 June 1898
Multidirectional Gradient Neighbourhood-Weighted Image Sharpness Evaluation Algorithm (2020)

Aiming at the problem that the image sharpness evaluation algorithm in the photoelectric system has a slow speed in actual processing and is severely disturbed by noise, an improved image sharpness evaluation algorithm is proposed by combining multiscale decomposition tools and multidirectional gradient neighbourhood weighting. This paper applies non-subsampled shearlet transform (NSST) to perform multiscale transformation of the input images, obtaining high-frequency sub-band images and low-frequency sub-band images. In order to enhance the detection of the edge orientation of images, multidirectional gradient processing of the image matrix is added to each sub-band image. In addition, the weight corresponding to the current pixel is obtained by calculating the inverse ratio of the gradient of each direction and the distance of the center pixel. Through calculating the ratio of the gradient neighbourhood weighting operators of high-frequency sub-band images and low-frequency sub-band images, the image sharpness evaluation value can be acquired further. Moreover, the image sequence collected by a certain type of photoelectric system is selected as the image sequence of the noisy real environment for simulation experiments and compared with the current mainstream algorithms. Finally, the experimental draws a conclusion that compared with the mainstream evaluation algorithms, the evaluation results of the proposed method perform better in terms of steepness, sensitivity, and flat area fluctuation, it can better suppress noise and improve accuracy, and its running speed meets the basic requirements of the image sharpness evaluation algorithm.
Crystal Structures of Cyclosporin Derivatives: O-Acetyl-(4R)-4-(E-2-butyl)-4,N-dimethyl-L-threonyl-cyclosporin A and O-Acetyl-(4R)-4-[E-2-(4-bromobutyl)]-4,N-dimethyl-L-threonyl-cyclosporin A (1999)

The structures of O -acetyl-(4 R )-4-( E -2-butyl)-4, N -dimethyl-L-threonyl-cyclosporin A ( 1 ) and O -acetyl-(4 R )-4-[ E -2-(4-bromobutyl)]-4, N -dimethyl-L-threonyl-cyclosporin A ( 2 ) were determined by X-ray diffraction methods and compared with the structure of related cyclosporins. In contrast to expectation, neither the acetylation nor the subsequent bromination of 1 affects the conformation and packing of cyclosporins in the solid state. Both compounds are isomorphous and crystallize in the orthorhombic space group P2 1 2 1 2 1 with a = 12.936(2) Å, b = 15.590(2) Å, c = 36.280(3) Å, and a = 12.916(3) Å, b = 15.675(4) Å, c = 36.715(7) Å, for 1 and 2 , respectively.
Special Nuclear Materials Detection Using IEC Fusion Pulsed Neutron Source (2009)

Special Nuclear Materials (SNM) detection efforts have largely been divided into two main groups: active and passive. Passive techniques are highly desirable in that a radiation source need not be employed in order to detect fissile materials which broadcast a clear radiative signature. However, disadvantages can be seen in HEU (Highly Enriched Uranium) detection, for example, where the system’s efficacy is limited by its ability to detect a weak self-radiative signature from U. Active interrogation provides a catalyst for amplifying HEU’s presence vis-a-vis fission event inducement, which in turn yields a starker signature which can be discerned through an understanding of fissile materials and neutron transport in various media. Ongoing work in the Fusion Technology Institute’s Inertial Electrostatic Confinement (IEC) Experiment has focused on using the pulsed D-D neutrons from an IEC to interrogate the presence of HEU in an enclosed space. The paper begins with a brief description of the neutron-based detection schemes of Delayed Neutron Analysis (DNA) and Differential Die-Away (DDA). Experimental delayed neutron counts of ninety above the background at an interrogating neutron flux of 5.5x104 n/cm2-s are seen to confirm MCNP modeling results. MCNP is also utilized to probe future concepts in neutron-based active interrogating SNM detection systems using DDA analysis.
Implementing non-invasive prenatal testing for aneuploidy in a national healthcare system: global challenges and national solutions (2017)

This study shows that implementing advanced technologies with profound effects on prenatal care benefit from a learning phase that allows time to carefully evaluate the technical performance and women's experiences and to enable public debate. Such a coordinated learning phase, involving all stakeholders, will stimulate the process of responsible and sustainable implementation.
Path following system of small unmanned autonomous vehicle for surveillance application (2011)

A path following flight control is developed to be implemented in a small UAV system. The path following control is designed such that the UAV is able to follow smooth flight-paths within its maneuvering capabilities. Payload space, weight, and power source constraints dictate the system to be designed with limited application of sensors and actuators, while it is still required to be able to perform its mission within a predefined measures. The control scheme is intended to be able to steer the UAV flight close to a predefined path and control its heading angle accordingly. The controller principally works by driving the cross-track and course angle errors of the UAV flight, relative to the desired path, to zero, through performing Bank to Turn (BTT) maneuvers. The system generates corrective commands based on the error information and transforms it into a heading change via roll maneuver. The roll maneuver controller is designed using LQR technique such that it can provide an appropriate roll dynamics of the UAV. Simulation results will be presented and analyzed to investigate the performance of the proposed system
A New Retina-Like Visual Sensor Performing the Polar Transform (1994)

This paper describes the development of an anthropomorphic visual sensor with retina-like structure to perform the polar mapping. The sensor consists of a dove prism for image rotation and a linear CCD sensor with 512 pixellline resolution, and holds approximately 45 Kbytes of image data. The retina-like sensor has variable resolution with increasing density towards the center of the visual field, and performs the polar transforming directly. The motion equation that relates the egomotion and/or the motion of the object in the scene to the optical flow is considerably simplified if the velocity is represented in a polar coordinate system, as opposed to a cartesian representation. Development of this sensor holds promise in application to high speed tracking systems, such as the eyes of navigation robots, because it has a data reduction characteristics and mapping function onto the polar plane. 1.
Carbohydrate antigen profiles of human erythroleukemia cell lines HEL and K562 (1983)

The expression of major carbohydrate antigens carried by polylactosaminyl chains in human erythroleukemia cell lines, K562 and HEL, was investigated by applying monoclonal antibodies recognizing specific carbohydrate determinants. The two cell lines showed common differences in their glycolipid compositions: (1) the presence of significant amounts of ganglio-series glycolipids, which are absent in normal erythrocytes; and (2) a remarkable reduction in the amount of globo-series glycolipids, which are the major glycolipids in normal human erythrocytes. A variety of differences were also detected in the carbohydrate antigens carried by lacto-series glycolipids and glycoproteins having related carbohydrate chains. K562 cells were i+H- X+, with a minor population of I+ cells. HEL cells were I-i+H+X-. The presence of the I+ population in K562 cells is particularly noteworthy, since I-antigen is characteristic of adult mature erythrocytes and is absent in most human leukemic cell lines. Several clones showing I+, I+/-i+/-, or I-i+ specificities were isolated from K562 cells by cloning in either methylcellulose media or limiting dilution, and I+ and I- cells were sorted by FACS fluorometer. HEL cells and these K562 clones provide a useful experimental model for studying the biologic significance and enzymatic control in expression of cell surface polylactosamines.
Identification and characterization of binding proteins for inhibin and activin in human serum and follicular fluids. (1993)

Inhibins and activins are produced by a variety of tissues and may have important endocrine and paracrine roles in development, reproduction, and hematopoiesis. However, little is known regarding the physical properties or concentrations of inhibin and activin in biological fluids. Binding proteins for inhibin or activin in serum or at production or target sites may have important implications for restricting the bioactivity of these hormones and may alter the immunoreactivity of these molecules in biological fluids. The objective of this study was to identify inhibin- and activin-binding proteins in human serum (HS) and follicular fluid (hFF) and determine the ability of these proteins to alter biological or immunological activity. In HS, [125I]activin and inhibin bound to a protein identified as alpha 2-macroglobulin (alpha 2M) using three criteria: 1) [125I]inhibin and activin bind purified alpha 2M, but not several other serum proteins tested; 2) complexes formed by [125I]inhibin and activin in HS and in the presence of purified alpha 2M elute with similar retention times on HPLC; and 3) preadsorption of HS with alpha 2M antiserum inhibits inhibin and activin binding to this protein while antiserum directed against follistatin or other serum proteins had no effect. A small amount of a lower mol wt [125I]activin-follistatin complex was also found in HS. This complex eluted with a retention time similar to that of activin bound to purified porcine follistatin. Binding of inhibin to follistatin could not be detected in HS. In contrast, follistatin was the major binding protein of both activin and inhibin in hFF. Concentrations up to 100 micrograms/ml purified alpha 2M had no effect on the bioactivity or immunoreactivity of either inhibin or activin. In contrast, follistatin inhibited both activin-stimulated pituitary FSH release and K562 hemoglobin production as well as antiserum binding in a specific activin-A immunoassay. Follistatin did not interfere with inhibin immunodetection. These data indicate that two inhibin- and activin-binding proteins are present in different relative amounts in HS and hFF, alpha 2M, the primary binding protein in HS, did not alter inhibin or activin bio- or immunoactivity under the conditions of these experiments, while follistatin, the major binding protein in hFF, may mask activin's bio- and immunoactivities.
Rapid and controlled deswelling of porous poly(<i>N</i>‐isopropylacrylamide) hydrogels prepared by the templating of interpenetrated nanoporous silica particles (2002)

Abstract Free radical polymerization of N ‐isopropylacrylamide (NIPAAm) and crosslinker solutions, which were fulfilled in silica particles with an interpenetrated and nanometer‐sized porous structure (a diameter of 3 mm and mean pore sizes of 15, 30, and 50 nm), fabricated hybrids of organic hydrogels and inorganic silica. Differential scanning calorimetric analyses of the hybrids revealed that silica components affected the thermoresponsive properties of polyNIPAAm hydrogels. Porous polyNIPAAm hydrogels were prepared by the subsequent acid treatment of the hybrids to remove silica. Transmission Fourier transformed infrared spectra indicated the selective extraction of silica. Scanning electron microscopic observation of the hydrogels confirmed the porous structure. The deswelling rate of porous hydrogels was 7 times larger than that of conventional hydrogels and increased with increasing the pore size of silica used. However, the swelling was not affected by the pore formation. The thermoresponsiveness of porous polyNIPAAm hydrogels could be regulated by the pore size. © 2002 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 40: 3542–3547, 2002
Multiwavelength technology for local loop applications (2003)

Some of the possible options for the exploitation of wavelength division multiplexing (WDM) techniques in the local loop are illustrated. It is noted that few-wavelength systems will probably be the first systems to be exploited, and early practical realizations are discussed. It is further suggested that the fuller exploitation of the optical spectrum available will be via much more extensive high-density WDM. Techniques are described showing that these opportunities could rapidly follow from few-wavelength systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Large area silicon on insulator by double-merged epitaxial lateral overgrowth (1992)

The process and feasibility verification for a full wafer silicon-on-insulator (SOI) process by using two merged epitaxial lateral overgrowths has been achieved. This process can be used to produce SOI material with a wide range of silicon thicknesses from 0.1 μm to several microns thick and is compatible with three-dimensional circuit integration. Formation of local area SOI islands, formation of vertical wall seed windows, and epitaxial lateral overgrowth from these narrow vertical seeds have been demonstrated. This SOI process has the potential to reduce the defect density and cost of SOI substrates.