gebhart/patrepeval huggingface dataset:
Imidazole Derivatives with Sympathomimetic Activity (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImidazole Derivatives with Sympathomimetic ActivityC. R. ScholzCite this: Ind. Eng. Chem. 1945, 37, 2, 120–125Publication Date (Print):February 1, 1945Publication History Published online1 May 2002Published inissue 1 February 1945https://doi.org/10.1021/ie50422a006RIGHTS & PERMISSIONSArticle Views116Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts
The Altered Gravitropic Response of the lazy-2 Mutant of Tomato Is Phytochrome Regulated (1993)

Shoots of the lazy-2 (lz-2) gravitropic mutant of tomato (Lycopersicon esculentum Mill.) have a normal gravitropic response when grown in the dark, but grow downward in response to gravity when grown in the light. Experiments were undertaken to investigate the nature of the light induction of the downward growth of lz-2 shoots. Red light was effective at causing downward growth of hypocotyls of lz-2 seedlings, whereas treatment with blue light did not alter the dark-grown (wild-type) gravity response. Downward growth of lz-2 seedlings is greatest 16 h after a 1-h red light irradiation, after which the seedlings begin to revert to the dark-grown phenotype. lz-2 seedlings irradiated with a far-red light pulse immediately after a red light pulse exhibited no downward growth. However, continuous red or far-red light both resulted in downward growth of lz-2 seedlings. Thus, the light induction of downward growth of lz-2 appears to involve the photoreceptor phytochrome. Fluence-response experiments indicate that the induction of downward growth of lz-2 by red light is a low-fluence phytochrome response, with a possible high-irradiance response component.
IOMRA - A High Efficiency Frequent Itemset Mining Algorithm Based on the MapReduce Computation Model (2014)

The goal of Frequent Item set Mining (FIM) is to find the biggest number of frequently used subsets from a big transaction database. In previous studies, using the advantage of multicore computing, the execution time of an Apriori algorithm was sharply decreased: when the size of a data set was more than TBs and a single host had been unable to afford a large number of operations by using a number of computers connected into a super computer to speed up execution as being the obvious solution. Some parallel Apriori algorithms, based on the MapReduce framework, have been proposed. However, with these algorithms, memory would be quickly exhausted and communication cost would rise sharply. This would greatly reduce execution efficiency. In this paper, we present an improved reformative Apriori algorithm that uses the length of each transaction to determine the size of the maximum merge candidate item sets. By reducing the production of low frequency item sets in Map function, memory exhaustion is ameliorated, greatly improving execution efficiency.
Effects of Cholinesterase Inhibitors on the Activities and Protein Levels of Cholinesterases in the Cerebrospinal Fluid of Patients with Alzheimers Disease: A Review of Recent Clinical Studies (2010)

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive decline associated with a deficit in cholinergic function. Inhibitors of acetylcholinesterase (AChE) and/or butyrylcholinesterase (BuChE), such as donepezil, galantamine or rivastigmine, are widely prescribed as symptomatic treatments for AD. These agents exhibit a wide variation in their pharmacological properties. Here we review clinical data from 1998 to 2009 investigating the effect of different cholinesterase inhibitor treatments on the levels and activities of cholinesterases in the cerebrospinal fluid (CSF) of AD patients. These studies suggest that treatment with rapidly-reversible cholinesterase inhibitors (e.g. donepezil, galantamine, tacrine) are associated with marked and significant upregulation of AChE activities and protein levels in the CSF of AD patients. In contrast, pseudo-irreversible cholinesterase inhibition (e.g. rivastigmine) is associated with a significant decrease in both CSF AChE and BuChE activities, with no upregulation of CSF protein levels. Additionally, donepezil is associated with a decrease in the level of the AChE-R isoform relative to the synaptic AChE-S isoform, whereas rivastigmine seems to increase this ratio. These findings suggest that these agents exert different effects on CSF cholinesterases. The clinical effects of these pharmacological differences are yet to be fully established.
Biochemical Characterization of Porphobilinogen Deaminase-Deficient Mice During Phenobarbital Induction of Heme Synthesis and the Effect of Enzyme Replacement (2003)

Acute intermittent porphyria (AIP) is a genetic disorder caused by a deficiency of porphobilinogen deaminase (PBGD), the 3rd enzyme in heme synthesis. It is clinically characterized by acute attacks of neuropsychiatric symptoms and biochemically by increased urinary excretion of the porphyrin precursors porphobilinogen (PBG) and 5-aminolevulinic acid (ALA). A mouse model that is partially deficient in PBGD and biochemically mimics AIP after induction of the hepatic ALA synthase by phenobarbital was used in this study to identify the site of formation of the presumably toxic porphyrin precursors and study the effect of enzyme-replacement therapy by using recombinant human PBGD (rhPBGD). After 4 d of phenobarbital administration, high levels of PBG and ALA were found in liver, kidney, plasma, and urine of the PBGD-deficient mice. The administration of rhPBGD intravenously or subcutaneously after a 4-d phenobarbital induction was shown to lower the PBG level in plasma in a dose-dependent manner with maximal effect seen after 30 min and 2 h, respectively. Injection of rhPBGD subcutaneously twice daily during a 4-d phenobarbital induction reduced urinary PBG excretion to 25% of the levels found in PBGD-deficient mice administered with only phenobarbital. This study points to the liver as the main producer of PBG and ALA in the phenobarbital-induced PBGD-deficient mice and demonstrates efficient removal of accumulated PBG in plasma and urine by enzyme-replacement therapy.
Enhancement of Meltdown Temperature of the Polyethylene Lithium-Ion Battery Separator via Surface Coating with Polymers Having High Thermal Resistance (2009)

When a lithium-ion battery is overcharged, it starts to self-heat because of exothermic reactions occurring within the components of the cell. Separator shutdown is a useful safety feature for preventing thermal runaway reactions in lithium-ion batteries. The polyethylene (PE) separators used here had shutdown temperatures of around 135 °C. Because the cell temperature continues to increase before actually beginning to cool even after shutdown, the separator should have a higher meltdown temperature than the shutdown temperature to work as an insulator even above the shutdown temperature. To enhance the meltdown temperature of the separator, in this study, a PE separator was coated with polymers synthesized from various ethylene glycol dimethacrylate monomers. When the separator was coated with polymer synthesized from diethylene glycol dimethacrylate (DEGDMA), its shutdown temperature and meltdown temperature were increased to 142 and 155 °C, respectively. Furthermore, a slight increase in the air permeability of the separator was observed when the separator was coated with polymer synthesized from an ethanol solution containing the proper amount of DEGDMA.
Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010 (2013)

GBD 2010 identified depressive disorders as a leading cause of burden. MDD was also a contributor of burden allocated to suicide and ischemic heart disease. These findings emphasize the importance of including depressive disorders as a public-health priority and implementing cost-effective interventions to reduce its burden. Please see later in the article for the Editors' Summary.
Intrathecal baclofen: A useful agent in the treatment of well-established complex regional pain syndrome (2002)

IT baclofen appears to be an option for patients with intractable CRPS who have failed other modalities, including IT morphine.
Complete nucleotide sequence and start sites for transcription and translation of the Bacillus megaterium protein C gene (1984)

The nucleotide sequence of the Bacillus megaterium protein C gene, encompassing the coding region and 341 base pairs of flanking regions, has been determined. The gene codes for a 72-residue protein whose predicted amino acid sequence is identical to that previously determined for protein C with the exception of an amino-terminal methionine predicted from the gene sequence, but not found in the mature protein. The translational initiation codon is preceded by an 11-base pair sequence highly complementary to the 3' terminus of B. megaterium 16S rRNA. Protection against S1 nuclease digestion by hybridization of a protein C gene fragment to RNA containing high levels of protein C mRNA localized the transcription initiation site 108 base pairs upstream from the translation start site. Upstream from the transcription initiation site there are no obvious homologies with conserved regions of promoters for previously described B. subtilis vegetative or sporulation genes.
A novel wiggly-line hairpin filter with 2nd spurious passband suppression (2004)

In this paper, a novel spurious response suppression hairpin handpass filter is proposed based on the reformulation of the sinusoidal modulation of the wiggly coupled-line. Equal phase velocity can he achieved by the asymmetrical strip width modulation, resulting in significant spurious bandpass suppression. In order to demonstrate the proposed filter performance, two prototype filters are designed @900MHz with 10% fractional bandwidth. From the simulation and experimental results, more than 15dB suppression in the 2nd harmonic spurious passband has been obtained.
Automated just-in-time compiler tuning (2010)

Managed runtime systems, such as a Java virtual machine (JVM), are complex pieces of software with many interacting components. The Just-In-Time (JIT) compiler is at the core of the virtual machine, however, tuning the compiler for optimum performance is a challenging task. There are (i) many compiler optimizations and options, (ii) there may be multiple optimization levels (e.g., -O0, -O1, -O2), each with a specific optimization plan consisting of a collection of optimizations, (iii) the Adaptive Optimization System (AOS) that decides which method to optimize to which optimization level requires fine-tuning, and (iv) the effectiveness of the optimizations depends on the application as well as on the hardware platform. Current practice is to manually tune the JIT compiler which is both tedious and very time-consuming, and in addition may lead to suboptimal performance.
Synthesis and Evaluation of New Antagonists of Bacterial Quorum Sensing in <i>Vibrio harveyi</i> (2009)

Bacterial quorum sensing has received much attention in recent years because of its relevance to pathological events such as biofilm formation. Based on the structures of two lead inhibitors (IC50: 35-55 microM) against autoinducer-2-mediated quorum sensing identified through virtual screening, we synthesized 39 analogues and examined their inhibitory activities. Twelve of these new analogues showed equal or better inhibitory activities than the lead inhibitors. The best compound showed an IC50 value of approximately 6 microM in a whole-cell assay using Vibrio harveyi as the model organism. The structure-activity relationship is discussed herein.
Posterior Precortical Vitreous Pocket in Children (2014)

The results suggest a progressive temporal extension of PPVP during childhood.
Classification of adjectival and non-adjectival nouns based on their semantic behavior by using a self-organizing semantic map (2002)

We treat nouns that behave adjectively, which we call adjectival nouns, extracted from large corpora. For example, in "financial world" and "world of finance," "financial" and "finance" are different parts of speech, but their semantic behaviors are similar to each other. We investigate how adjectival nouns are similar to adjectives and different from non-adjectival nouns by using self-organizing semantic maps. We create five kinds of semantic maps, i.e., semantic maps of abstract nouns organized via (1) adjectives, (2) adjectival nouns, (3) non-adjectival nouns and (4) adjectival and adjectival nouns and a semantic map of adjectives, adjectival nouns and non-adjectival nouns organized via collocated abstract nouns, and compare them with each other to find similarities and differences.
Taurine chloramine inhibits the synthesis of nitric oxide and the release of tumor necrosis factor in activated RAW 264.7 cells (1993)

Taurine is present in high concentrations in most mammalian tissues, including those that prodigiously produce oxidants. Taurine protects against bronchiolar damage induced by NO2, ozone, bleomycin, and amiodarone. Taurine is chlorinated to form taurine chloramine (Tau-Cl) by the halide-dependent myeloperoxidase system and, under physiological conditions, reduces HOCl toxicity. Although NO and its metabolites, NO2- and NO3-, are thought to be major mediators of tissue damage resulting from oxidant exposure, cytokines, including tumor necrosis factor (TNF), are also involved. We examined the effects of Tau-Cl on NO production and TNF release by using RAW 264.7 cells activated with recombinant interferon-gamma (rIFN-gamma; 50 U/ml) and lipopolysaccharide (LPS; 10 micrograms/ml). NO was measured spectrophotometrically as NO2- after reaction with Griess reagent and TNF was measured by ELISA. Tau-Cl (0.5 mM) inhibits NO and TNF released into the medium by 47% and 43%, respectively. Tau-Cl is actively transported into RAW 264.7 cells by an uptake system that is energy, temperature, and Na+ dependent. Competition experiments demonstrate that the uptake system for Tau-Cl is distinct from that for taurine. In addition, the NO synthase activity of cytosolic preparations from activated RAW 264.7 cells is irreversibly inhibited by pretreatment with Tau-Cl. We demonstrate that Tau-Cl inhibits production of NO and TNF by activated macrophages and suggest a mechanism through which taurine supplementation may protect against oxidant-induced tissue damage.
Applications Of Wavefront Reversal By Stimulated Brillouin Scattering (1982)

Wavefront reversal (WFR) via stimulated Brillouin scattering (SBS) is shown to possess the capability to compensate for phase aberrations in laser media and also to temporally compress long laser pulses. Such techniques, which involve passive and lightweight conjugator elements, are believed to be simple and practical.
Influence of Incubation Atmosphere on Growth and Amino Acid Requirements of <i>Streptococcus mutans</i> (1974)

The growth response of Streptococcus mutans representing antigenic type a or d in a chemically defined medium was influenced by the oxygen concentration of the growth atmosphere. Under controlled aerobic (1.5% O(2)) conditions these cultures attained a greater density than when the atmosphere contained 0.006% O(2) or less. The growth of S. mutans strains representing antigenic types b or c in the defined medium was independent of the oxygen concentration of the growth environment. Under the conditions used in this study, none of the strains tested could utilize ammonium ion as a sole source of nitrogen for growth. The requirement for certain amino acids and inhibition by other amino acids varied with antigenic type and relative oxygen concentration of the growth environment. Under conditions where the atmospheric oxygen was reduced to 0.0006% O(2) or less, the amino acid requirements of the cultures became either more numerous or more stringent. S. mutans strains of type c generally required the least number of amino acids, whereas cultures of type d had more numerous requirements. Nearly every culture tested under the anaerobic atmosphere was inhibited by one of the branched-chain amino acids, leucine, valine, or isoleucine. Methionine and lysine were also found to be inhibitory, particularly toward the type c strains.
Enantioselective Enzymatic Desymmetrizations in Organic Synthesis (2004)

During the recent past years, tremendous efforts have been made to establish enantioselective routes for the preparation of enantiomerically pure compounds due to their importance in the pharmaceutical, agricultural, and food industries. This is reflected in the fact that the sales of single-enantiomer small-molecule drugs has reached c. US $10 billion in 2002.1 Moreover, the FDA has become increasingly reluctant to permit the introduction of additional racemic drugs, as these therapies are by definition saddled with 50% of chemical ballast.2 Enzymes are nowadays widely recognized among the most active and selective catalysts for the preparation of optically active compounds.3 Some of the factors that account for this popularity are (1) They are chemo-, regio-, and stereoselective, and environmentally friendly. (2) Because of the mild conditions under which they operate, enzymatic reactions are affected to a lesser extent by side reactions (viz. isomerization, racemization, epimerization, and rearrangement of molecules) as compared to nonenzymatic processes. Nevertheless, organic chemists have been traditionally reluctant to employ biocatalysts in their syntheses. This is mainly because, in their natural form, most of the enzymes are very sensitive catalysts that exert their activity mainly in aqueous solution. Moreover, their handling requires some biochemistry knowledge. However, some recent advances carried out in the biocatalysis field have “approached” enzymes to organic synthesis: (a) They can operate in nonaqueous media accepting a broad range of substrates;4 (b) immobilization techniques increase their stability and simplify their handling.5 Thus, many enzymes can now be acquired and used as any other chemical.
Systolic evaluation of polynomial expressions (1990)

Two types of organizations are presented for frame buffers of m*m pixels: one is a single wavefront complex cell array requiring O(m/sup 2/n) space and the other is a simple cell multiple wavefront array with O(m/sup 2/) area and O(n/sup 2/) wavefronts. Both these organizations have two main advantages over an earlier method: the cells and the interconnection among them are regular and hence are suitable for efficient VLSI implementation, and the organization permits evaluation of higher-order polynomials.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Long-Term Clinical Outcomes After Unprotected Left Main Trunk Percutaneous Revascularization in 279 Patients (2001)

Patients undergoing unprotected LMT PCI have frequent serious comorbidities and consequently have high event rates. PCI may be an alternative to CABG for a select proportion of elective patients and may also be appropriate for highly symptomatic inoperable patients. Meticulous follow-up of hospital survivors is required because of the rather high mortality during the first few months after treatment.
ChemInform Abstract: SALZ‐ UND LOESUNGSMITTELEFFEKTE AUF RK.‐GESCHWINDIGKEITEN IN KONZENTRIERTEN LOESUNGEN VON SAEUREN UND BASEN (1972)

Abstract (Übersicht.
Effects of various cryoprotective agents on the survival of unfrozen and frozen mouse embryos (1981)

The effects of DMSO, ethylene glycol, glycerol, erythritol, dimethylformamide and sucrose on the survival of unfrozen and frozen mouse morulae were examined. All the agents had a deleterious effect on survival of the unfrozen morulae at 20 degrees C. The harmful effect of erythritol was lower at 0 degrees C and sucrose had a protective effect at that temperature. Dimethylformamide and DMSO were more harmful than ethylene glycol and glycerol at both temperatures. Higher proportions of the morulae frozen in DMSO developed into expanded blastocysts when slowly frozen samples were thawed slowly (82%) than when they were thawed rapidly (85%) than when they were thawed slowly (4%). When the samples were frozen in the presence of ethylene glycol or glycerol, higher survival rates were obtained after slow (80--94%) than rapid (1--59%) freezing. When erythritol was used, only embryos thawed rapidly developed (31--50%) in subsequent cultures. Sucrose and dimethylformamide did not afford cryoprotection. Morulae frozen--thawed rapidly in the presence of ethylene glycol, glycerol or erythritol and transferred to recipients developed into normal young.
Re‐evaluation of the primary structure of <i>Ralstonia eutropha</i> phasin and implications for polyhydroxyalkanoic acid granule binding (1999)

Sequence analysis of several cDNAs encoding the phasin protein of Ralstonia eutropha indicated that the carboxyl terminus of the resulting derived protein sequence is different from that reported previously. This was confirmed by: (1) sequencing of the genomic DNA; (2) SDS-PAGE and peptide analysis of wild-type and recombinant phasin; and (3) mass spectrometry of wild-type phasin protein. The results have implications for the model proposed for the binding of this protein to polyhydroxyalkanoic acid granules in the bacterium.
Ferulic Acid Esterase Activity from <i>Schizophyllum commune</i> (1988)

Schizophyllum commune produced an esterase which released ferulic acid from starch-free wheat bran and from a soluble ferulic acid-sugar ester that was isolated from wheat bran. The preferred growth substrate for the production of ferulic acid esterase was cellulose. Growth on xylan-containing substrates (oat spelt xylan and starch-free wheat bran) resulted in activity levels that were significantly lower than those observed in cultures grown on cellulose. Similar observations were made for endoglucanase, p-nitrophenyllactopyranosidase, xylanase, and acetyl xylan esterase. Of the enzymes studied, only arabinofuranosidase was produced at maximum levels during growth on xylan-containing materials. Ferulic acid esterase that had been partially purified by DEAE chromatography released significant amounts of ferulic acid from wheat bran only in the presence of a xylanase-rich fraction, indicating that the esterase may not be able to readily attack high-molecular-weight substrates. The esterase acted efficiently, without xylanase addition, on a soluble sugar-ferulic acid substrate.
A 400 MHz, 300 mW, 8 kb, CMOS SRAM macro with a current sensing scheme (2002)

This paper describes the development of a 400 MHz, 8 kb, 0.4 /spl mu/m CMOS SRAM macro targeted for use in on-chip cache memories. A newly developed pipeline scheme uses a dynamic decoder and half-latches to increase speed by 10% over that of conventional synchronous pipeline SRAMs. Further, a newly developed current sensing scheme, resistant both to noise and to process deviations, contributes to a job reduction in power dissipation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>