gebhart/patrepeval huggingface dataset:
Effects of Bacterial ACC Deaminase on<i>Brassica napus</i>Gene Expression (2012)

Plants in association with plant growth-promoting rhizobacteria can benefit from lower plant ethylene levels through the action of the bacterial enzyme 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase. This enzyme cleaves the immediate biosynthetic precursor of ethylene, ACC. Ethylene is responsible for many aspects of plant growth and development but, under stressful conditions, it exacerbates stress symptoms. The ACC deaminase-containing bacterium Pseudomonas putida UW4 is a potent plant growth-promoting strain and, as such, was used to elaborate the detailed role of bacterial ACC deaminase in Brassica napus (canola) plant growth promotion. Transcriptional changes in bacterially treated canola plants were investigated with the use of an Arabidopsis thaliana oligonucleotide microarray. A heterologous approach was necessary because there are few tools available at present to measure global expression changes in nonmodel organisms, specifically with the sensitivity of microarrays. The results indicate that the transcription of genes involved in plant hormone regulation, secondary metabolism, and stress response was altered in plants by the presence of the bacterium, whereas the upregulation of genes for auxin response factors and the downregulation of stress response genes was observed only in the presence of bacterial ACC deaminase. These results support the suggestion that there is a direct link between ethylene and the auxin response, which has been suggested from physiological studies, and provide more evidence for the stress-reducing benefits of ACC deaminase-expressing plant growth-promoting bacteria.
Fabrication and properties of microforged ferromagnetic nanoflakes (1998)

Ferromagnetic nanoflakes (quasi-oblate spheroids of soft ferromagnetic alloys with submicron thicknesses and aspect ratios of 10-100) can be processed by microforging micron scale powders in a ball mill. Nanoflakes are potentially useful in fabricating microwave effective media, but the magnetic properties of microforged ferromagnetic flakes have not been previously studied. In this study, we produced ferromagnetic nanoflakes from gas atomized powders of several types of Fe, and alloy powders of FeSi and NiFe. SEM micrographs and sieving fractions show that nanoflakes can be made with thicknesses /spl sim/0.4 /spl mu/m, and that more than 95% of the initial powder mass can be converted into nanoflakes with aspect ratios greater than 50. Magnetic measurements show that composites of planar nanoflakes have magnetic remanences /spl sim/25% M/sub s/, /spl mu/'s that correlate with the aspect ratio (to values >50), and eddy currents suppressed to frequencies >200 MHz.
Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics (2017)

The repositioning or "repurposing" of existing therapies for alternative disease indications is an attractive approach that can save significant investments of time and money during drug development. For cancer indications, the primary goal of repurposed therapies is on efficacy, with less restriction on safety due to the immediate need to treat this patient population. This report provides a high-level overview of how drug developers pursuing repurposed assets have previously navigated funding efforts, regulatory affairs, and intellectual property laws to commercialize these "new" medicines in oncology. This article provides insight into funding programs (e.g., government grants and philanthropic organizations) that academic and corporate initiatives can leverage to repurpose drugs for cancer. In addition, we highlight previous examples where secondary uses of existing, Food and Drug Administration- or European Medicines Agency-approved therapies have been predicted <i>in silico</i> and successfully validated <i>in vitro</i> and/or <i>in vivo</i> (i.e., animal models and human clinical trials) for certain oncology indications. Finally, we describe the strategies that the pharmaceutical industry has previously employed to navigate regulatory considerations and successfully commercialize their drug products. These factors must be carefully considered when repurposing existing drugs for cancer to best benefit patients and drug developers alike.
Comparison of prediction schemes with motion information reuse for low complexity spatial scalability (2005)

Three low complexity algorithms that allow spatial scalability in the context of video coding are presented in this paper. We discussed the feasibility of reusing motion and residual texture information of the base layer in the enhancement layer. The prediction errors that arise from the discussed filters and schemes are evaluated in terms of the Mean of Absolute Differences. For the interpolation of the decoded pictures from the base layer, the presented 6-tap and bicubic filters perform significantly better than the bilinear and nearest neighbor filters. In contrast, when reusing the motion vector field and the error pictures of the base layer, the bilinear filter performs best for the interpolation of residual texture information. In general, reusing the motion vector field and the error pictures of the base layer gives the lowest prediction errors. However, our tests showed that for some sequences that have regions with complex motion activity, interpolating the decoded picture of the base layer gives best result. This means that an encoder should compare all possible prediction schemes combined with all interpolation filters in order to achieve optimal prediction. Obviously this would not be possible for real-time content creation.
Oxygen detection in thin silicon dioxide layers by low-energy x-ray fluorescence spectrometry (1993)

Light element detection using low-energy (&lt;2 keV) x-ray fluorescence (XRF) is described. By tuning the energy of the incident x rays to slightly above the absorption edge, the minimum detection limits for low-Z elements can be greatly improved over conventional XRF and signal-to-background is significantly better than that obtainable for electron-excited x-ray spectra using an energy-dispersive detector. In particular, the minimum detectable thickness of SiO2 is experimentally determined to be 0.36 Å (≊0.1 monolayer) film thickness for 1.85 kV anode voltage using a Mg anode with an Al window. Good signal linearity with film thickness is established by comparison with measurements obtained on the same samples using ellipsometry and x-ray photoelectron spectroscopy.
Functional map of biological and biomimetic materials with hierarchical surface structures (2015)

The properties and functions of both biological and artificial materials with hierarchical surface structures are reviewed to establish the functional map of various hierarchical surface structures.
Dependability: Important Factor for the Success of Electronic Health Record Systems (2003)

Improving quality of healthcare and patient safety are the focus of healthcare industry. Electronic health record systems are part of the healthcare system and it is important that electronic health record systems will assist in improving the quality of care. Patient's sensitive data are stored in the electronic health record systems and it is imperative that data quality of the electronic health record systems should be maintained. The research will identify the relationship framework of dependability and how the information processing of electronic health record is related to the data quality. Dependability can be categorised into availability, reliability, security and safety from software engineering perspectives and the paper would explain applying dependability in the electronic health record systems. Only the dependable electronic health record systems would maintain the data quality attributes such as accuracy, accessibility, consistency, comprehensiveness, currency and timeliness.
Effect of ultrafiltration of yeast extracts on their ability to promote lactic acid bacteria growth (1999)

Five yeast extracts (YE) were fractionated by ultrafiltration (UF) with 1, 3, and 10 kDa molecular weight cutoff membranes, concentrated by freeze-drying, and the resulting powders of yeast extract filtrates (YEF) were evaluated for their growth-promoting properties on nine cultures of lactic acid bacteria (LAB). There was an increase in alpha-amino nitrogen content of the YEF powders as the pore size of the UF membranes used to filter the YE solutions decreased. The source of YE had a much greater effect than UF on the growth of LAB. This was also the case for the YEF contents in total and alpha-amino nitrogen. Growth curves of the LAB showed that maximum growth rate (mumax) data were on average 30% higher with bakers' YE than with brewers' YE, while maximum optical density (ODmax) values were on average 16% higher with bakers' YE. This could be related to the higher nitrogen content of the bakers' YE used in this study. Modification by UF of the YE had no significant influence on the growth of 4 of the 9 LAB strains. The three strains of Lactobacillus casei were negatively influenced by UF, as they did not grow as well in the media containing the YEF obtained after filtering with 1 and 3 kDa membranes. On a total solids basis, the 2.5 x retentates from the 10 kDa membrane gave, on average, 4% lower mumax and 5% lower ODmax values as compared to cultures where the corresponding YEF was used as medium supplement. This could also be partially related to the different nitrogen contents of the filtrates and retentates.
JumpCut (2015)

We introduce JumpCut, a new mask transfer and interpolation method for interactive video cutout. Given a source frame for which a foreground mask is already available, we compute an estimate of the foreground mask at another, typically non-successive, target frame. Observing that the background and foreground regions typically exhibit different motions, we leverage these differences by computing two separate nearest-neighbor fields (split-NNF) from the target to the source frame. These NNFs are then used to jointly predict a coherent labeling of the pixels in the target frame. The same split-NNF is also used to aid a novel edge classifier in detecting silhouette edges (S-edges) that separate the foreground from the background. A modified level set method is then applied to produce a clean mask, based on the pixel labels and the S-edges computed by the previous two steps. The resulting mask transfer method may also be used for coherently interpolating the foreground masks between two distant source frames. Our results demonstrate that the proposed method is significantly more accurate than the existing state-of-the-art on a wide variety of video sequences. Thus, it reduces the required amount of user effort, and provides a basis for an effective interactive video object cutout tool.
Priority-based multiple access (PBMA) for statistical multiplexing of multiple services in wireless PCS (2002)

A priority based multiple access scheme is proposed to provide multiple services for wireless PCS. The scheme is then applied to the UMTS air interface with emphasis on voice, low delay data, ATM cell relay, and high delay data services. Simulation results are reported to illustrate the performance of the proposed priority-based access scheme in terms of QoS requirements and system capacity.
Flow cytofluorometric analysis of the nuclear division cycle of <i>Physarum polycephalum</i> plasmodia (1981)

The nuclear cycle kinetics of Physarum polycephalum plasmodia were examined using flow cytofluorometry. The dyes Hoechst 33342 and propidium iodide were used to stain the DNA of isolated nuclei. In asynchronously growing microplasmodia. S phase consists of 13--15% of the nuclear division cycle time. Nuclei isolated from individual macroplasmodia, which have previously been demonstrated to divide in synchrony, were shown to be less synchronized during late S phase than during mitosis. The results obtained demonstrate the feasibility of flow cytometric measurement of the properties of nuclei isolated from a single cell.
Automated production of [sup 124]I and [sup 64]Cu using IBA Terimo and Pinctada metal electroplating and processing modules (2012)

There is worldwide growing interest for the production of long-lived positron emitters for molecular imaging and the development of novel immuno-PET techniques for drugs discovery. The desire to produce solid target isotopes in Australia has significantly increased over the years and several research projects for labelling of peptides, proteins and biomolecules, including labelling of recombinant antibodies has been limited due to the availability of suitable isotopes. This has led to the recent installation and commissioning of a new lab dedicated to fully automated solid target isotope production, including 124I, 64Cu, 89Zr and 86Y.
Evolutionary co-operative design between human and computer (2000)

The Genetic Sculpture Park seeks to blur the distinction between artist and observer and to empower the novice in the creation of complex computer graphic models. Each visitor to the park experiences a unique set of forms and engages in a co-operative dialogue with the computer to produce more aesthetically pleasing designs. Inspired by Darwin's Theory of Evolution, Genetic Algorithms are used to allow visitors to 'breed' forms tailored to his or her own individual sense of aesthetics. This paper recounts investigations into evolutionary design methodologies (“3D Head Models”) and describes their implementation in an interactive Java/VRML world.
Robust EPI Nyquist ghost removal by incorporating phase error correction with sensitivity encoding (PEC‐SENSE) (2017)

The proposed correction method can robustly eliminate Nyquist ghost while preserving the image SNR. This approach requires no additional calibration data beyond standard coil sensitivity maps and can be readily applied to all EPI applications. Magn Reson Med 79:943-951, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Uniform Ant-Hills in the world of Golden Isozonohedra (1980)

Get article est compose de trois parties. La premiere partie (par Koji Miyazaki) introduit le monde étrange des “isozonaedres dorés” qui n’ont qu’un seul type de face, le diamant dot-e.\nLes plans urbanises et les designs architecturaux de par le monde sont bases sur de tels modeles\nperiodiques, ou parfois essentiellement nonperiodiques.\nLa seconde partie (par jchiro Takada) traite des fourmilieres uniformes dans lesquelles les polyedres reguliers sont lies les uns aux autres face a face, laissant maints tunnels finis (non-infinis).\nLeur forme fait penser a une fourmiliere, ou aux anneaux lies des molecules. \nLa troisieme partie (par Koji Miyazaki) associe les deux idees d&rites ci-dessus. Les isozonaedres dorés sont construits comme des fourmilieres uniformes nes de dodecaedres reguliers. En d’autres termes, le curieux modele non-periodique que I’on voit dans le monde de I’isozonaedre doré peut etre construit en utilisant tout simplement des dodecaedres réguliers.
Lithiation–Electrophilic Substitution of <i>N</i>‐Thiopivaloylazetidine (2010)

The fourth protocol: the rarely studied N-thiopivaloyl group plays a crucial role in mediating efficient α lithiation and incorporation of diverse electrophiles onto an azetidine ring; in the presence of chiral ligands, this chemistry also provides the first example of an enantioselective electrophilic substitution on a four-membered ring.
Aggregation of human platelets by amniotic fluid (1982)

Twenty-four amniotic fluid samples were examined for their effects on human platelets. All samples caused irreversible platelet aggregation. The active material precipitated with high-speed ultracentrifugation and was completely inhibited by prior incubation with purified collagenase. The presence of free collagen in amniotic fluid was further confirmed by polyacrylamide-gel electrophoresis and hydroxyproline assays. Beside platelet-aggregating activity, amniotic fluid samples were also shown to significantly shorten the recalcification time of normal plasma. This procoagulant activity appears to be related to the presence of thromboplastin, collagen and other as yet unidentified procoagulant material in amniotic fluid. The presence of activators of platelets and clotting factors in amniotic fluid would account for the strong clot-promoting activity of this fluid. These studies suggest that the ideal management of the coagulopathy of pregnancy should include a combination of anticoagulant and antiplatelet drugs.
A New Diterpene Acid From Salvia tomentosa (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Diterpene Acid From Salvia tomentosaA. Ulubelen, M. Miski, and T. J. MabryCite this: J. Nat. Prod. 1981, 44, 1, 119–124Publication Date (Print):February 1, 1981Publication History Published online1 July 2004Published inissue 1 February 1981https://pubs.acs.org/doi/10.1021/np50013a022https://doi.org/10.1021/np50013a022research-articleACS PublicationsRequest reuse permissionsArticle Views383Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A ±30% tuning range varactor compatible with future scaled technologies (2002)

A /spl plusmn/30% capacitance modulation of a new variable capacitor has been achieved for a 2 V variation in the controlling bias voltage. The realized varactor is based on a polysilicon/oxide/n-well structure, implemented in a 0.35 /spl mu/m standard CMOS process. The quality factor for a 3.1 pF sample ranges from 17 to 33, at 1800 MHz.
Synthesis and Biological Activities of the Antibiotic B 371 and its Analogs (1984)

Abstract The synthesis of the title compound 1 is described as well as the syntheses of a series of structural analogs of type 4 . The antimicrobial in vitro activity of these vinyl isocyanides, substituted in β‐position either by an indole derivative or by an aryl or 2‐thienyl group, was tested against Escherichia Coli, Bacillus subtilis , and Mucor muhei TÜ 284 (Table 1). Some of the compounds 4 display higher activity than the naturally occurring parent compound 1 . — A variety of alkyl 2‐isocyanoacrylates of type 5 were included in the biological test. Some of them display exceptionally high antimicrobial activity (Table 2). Upon conversion of the isocyano group into the formamido group ( 4 → 6 ), the biological activity is lost.
Macimorelin (AEZS-130)-Stimulated Growth Hormone (GH) Test: Validation of a Novel Oral Stimulation Test for the Diagnosis of Adult GH Deficiency (2013)

Oral macimorelin is safe, convenient, and effective in diagnosing AGHD with accuracy comparable with the arginine+GHRH test.
Anomalous Time-of-Flight Distributions Observed for Argon Implanted in Silicon and Resputtered by<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow><mml:mi mathvariant="normal">Ar</mml:mi></mml:mrow><mml:mrow><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:math>-Ion Bombardment (1986)

A Si substrate is bombarded by 3-keV ${\mathrm{Ar}}^{+}$ ions. From time-of-flight spectra of resputtered Ar neutrals at various target temperatures, we conclude that Ar-bubble formation takes place in the amorphized-Si top layer. The bubbles form and open during etching. The average kinetic energy of the Ar atoms is in agreement with the calculated average potential energy of the Ar atoms inside the bubbles.
Differential carrier loop estimation for digital vestigial side band modulation (2002)

In this paper we address the problem of phase recovery for a digital VSB modulation. Two criteria, a Constant Modulus and MSE, which exploit the properties of VSB signaling in the presence of noise are proposed and analyzed. The extrema of the objective functions and their domains of attraction are derived. Under mild conditions on the statistics of the input sequence, it is shown that the derivative of these functions can be used as a new phase detector in a Phase Locked Loop (PLL) implementation. An effective semi-blind solution which consists of a combination of the MSE and CM phase detectors is introduced and analyzed.
Photonic crystal structures on nonflat surfaces fabricated by dry lift-off soft UV nanoimprint lithography (2013)

The surface nonflatness induced from the material itself or the production atmosphere can lead to serious non-uniformity consequences in nanoimprint lithography (NIL) which is used for providing a low cost and high throughput nano-fabrication process. In this paper, soft UV NIL (SUNIL) processes are used for photonic crystal (PC) pattern transfer of a GaN-based light-emitting diode (LED) with patterned sapphire substrate (PSS). The results reveal a significant incompatibility between the conventional SUNIL and the nonflat p-GaN surface. Ellipse-shaped rather than circle-shaped PC structure is obtained on the p-GaN surface due the deformation of the soft mold in nonflat NIL. A dry lift-off (DLO) SUNIL is proposed to overcome the non-uniformity issue in nonflat NIL as well as the collapse problem of the free-standing pillar-shaped resist in wet lift-off. The photoluminescence enhancements of the LED fabricated by the DLO SUNIL method compared to those with conventional SUNIL and unpatterned LED are 1.41 fold and 3.48 fold, respectively. Further study shows that the DLO SUNIL is applicable in the fabrication of the PC structure with tunable duty cycle via one single initial PC mold.
COMETS 21-GHz advanced satellite broadcasting experiments-evaluation of trellis-coded 8-PSK performance (2000)

An advanced satellite broadcasting system using 21 GHz has been studied by using the high-power (200 W) and wideband (120 MHz) transponders on the Communication and Broadcasting Engineering Test Satellite (COMETS), which was launched 21 February 1998. A highly effective trellis-coded eight-phase-shift-keying (TC8PSK) modem was developed for the COMETS satellite broadcasting experiments, and this paper describes the degradation in the bit error performance of the TC8PSK modem due to the nonlinear amplification (AM/AM distortion and AM/PM conversion effects), group-delay distortion, and amplitude-frequency characteristics of the satellite transponder. The results of the COMETS experiments and computer simulations indicate that the performance degradation is due primarily to the nonlinear distortion and the amplitude-frequency characteristics of the traveling wave tube amplifiers in the transponder.
Designing innovative reading experiences for a museum exhibition (2001)

Rather than eliminating reading as many fear, digital technology actually facilitates a wide array of exciting and unusual reading experiences. A research team at Xerox PARC has created a museum exhibition called XFR that provides a glimpse into the future of reading forms and how we will interact with them. The exhibit stimulates an awareness of the ubiquity of reading and its continued importance in the digital age. It also explores the range of exciting reading experiences made possible by new technology, from interactive readers to large-scale reading walls to dynamic narratives that change in response to reader input. Because the XFR show took place within the context of a modern technology museum, most of the exhibits are interactive and hands-on.