gebhart/patrepeval huggingface dataset:
An Adaptive GTS Allocation Scheme for IEEE 802.15.4 (2008)

IEEE 802.15.4 is a new standard uniquely designed for low-rate wireless personal area networks. It targets ultralow complexity, cost, and power for low-rate wireless connectivity among inexpensive, portable, and moving devices. IEEE 802.15.4 provides a guaranteed time slot (GTS) mechanism to allocate a specific duration within a superframe for time-critical transmissions. This paper proposes an adaptive GTS allocation (AGA) scheme for IEEE 802.15.4, which considers low latency and fairness. The scheme is designed based on the existing IEEE 802.15.4 medium access control protocol, and IEEE 802.15.4 devices can receive this AGA service without any modification. A simulation model and an analytical model are developed to investigate the performance of our AGA scheme. The numerical results show that the proposed scheme significantly outperforms the existing IEEE 802.15.4 implementation.
Structure and Function of Window Glass and Pyrex (2006)

Window glass is a ternary mixture, while pyrex (after window glass, the most common form of commercial glass) is a quaternary. Building on our previous success in deriving the composition of window glass (sodium calcium silicate) without adjustable parameters, and borrowing from known reconstructed crystalline surfaces, we model pyrex as silica clusters with a specific ternary interface. Our global model explains the thermal expansivity contours of ternary sodium borosilicates, and it is consistent with the optimized resistance of pyrex to mechanical and thermal shocks. It suggests new directions for studying the nanoscopic structure of these remarkable materials.
Illihenin A: An Antiviral Sesquiterpenoid with a Cage-like Tricyclo[6.2.2.0<sup>1,5</sup>]dodecane Skeleton from <i>Illicium henryi</i> (2021)

Illihenin A (<b>1</b>), a novel sesquiterpenoid, was isolated from the roots of <i>Illicium henryi</i>. The structure was determined by spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction. Compound <b>1</b> represents a class of novel 5/7/6 tricyclic sesquiterpenoids featuring a rare cage-like tricyclo[6.2.2.0<sup>1,5</sup>]dodecane core. A plausible biosynthetic pathway of <b>1</b> by rearrangement of <i>allo</i>-cedrane is proposed. Additionally, <b>1</b> showed potent antiviral activity against coxsackievirus B3 with an IC<sub>50</sub> value of 2.87 μM.
Producing Patriotic Inspiration at Mount Rushmore (1994)

Journal Article Producing Patriotic Inspiration at Mount Rushmore Get access Matthew Glass Matthew Glass Search for other works by this author on: Oxford Academic Google Scholar Journal of the American Academy of Religion, Volume LXII, Issue 2, Summer 1994, Pages 265–283, https://doi.org/10.1093/jaarel/LXII.2.265 Published: 01 July 1994
Identification of Rifampin-Resistant <i>Mycobacterium tuberculosis</i> Strains by Hybridization, PCR, and Ligase Detection Reaction on Oligonucleotide Microchips (2001)

Three new molecular approaches were developed to identify drug-resistant strains of Mycobacterium tuberculosis using biochips with oligonucleotides immobilized in polyacrylamide gel pads. These approaches are significantly faster than traditional bacteriological methods. All three approaches-hybridization, PCR, and ligase detection reaction--were designed to analyze an 81-bp fragment of the gene rpoB encoding the beta-subunit of RNA polymerase, where most known mutations of rifampin resistance are located. The call set for hybridization analysis consisted of 42 immobilized oligonucleotides and enabled us to identify 30 mutant variants of the rpoB gene within 24 h. These variants are found in 95% of all mutants whose rifampin resistance is caused by mutations in the 81-bp fragment. Using the second approach, allele-specific on-chip PCR, it was possible to directly identify mutations in clinical samples within 1.5 h. The third approach, on-chip ligase detection reaction, was sensitive enough to reveal rifampin-resistant strains in a model mixture containing 1% of resistant and 99% of susceptible bacteria. This level of sensitivity is comparable to that from the determination of M. tuberculosis drug resistance by using standard bacteriological tests.
Experimental study of a co-flowing jet in ONERA’s F2 research wind tunnel by 3D background oriented schlieren (2017)

International audience
In vitro mutational analysis of cis-acting RNA translational elements within the poliovirus type 2 5' untranslated region (1991)

Initiation of translation on poliovirus RNA occurs by internal binding of ribosomes to a region within the 5' untranslated region (UTR) of the mRNA. This region has been previously roughly mapped between nucleotides 140 and 631 of the 5' UTR and termed the ribosome landing pad. To identify cis-acting elements in the 5' UTR of poliovirus type 2 (Lansing strain) RNA that confer cap-independent internal initiation, we determined the in vitro translational efficiencies of a series of deletion and point mutations within the 5' UTR of the mRNA. The results demonstrate that the 3' border of the core poliovirus ribosome landing pad is located between nucleotides 556 and 585, whereas a region extending between nucleotides 585 and 612 confers enhanced translation. We studied two cis-acting elements within this region of the 5' UTR: a pyrimidine stretch which is critical for translation and an AUG (number 7 from the 5' end) that is located approximately 20 nucleotides downstream from the pyrimidine stretch and augments translation. We also show that the stem-loop structure which contains this AUG is not required for translation.
Hardware implementation for census 3D disparity map with dynamic search range estimation (2011)

In this paper, a new hardware implementation for the real time disparity map is presented. The real time disparity map includes the Dynamic Search Range Estimation, Disparity estimation, and Error Correction. Our demonstrated design flow shows an approach to implementation and hardware architecture of real-time disparity map estimation. This design is efficiently synthesized on Xilinx vertex 5 VLX 330 FPGA. The resulting hardware implementation is analyzed and simulated for system clock speed 100MHz to verify adequate performance. Since the algorithm is not so complicated to adapt real-time hardware design, we successfully made system with FPGA Prototype design.
Probing Multidrug Resistance P-glycoprotein Transporter Activity with SPECT Radiopharmaceuticals (2010)

Multidrug resistance (MDR) mediated by overexpression of MDR1 (ABCB1) P-glycoprotein (Pgp) is one of the best characterized transporter-mediated barriers to successful chemotherapy in cancer patients and is also a rapidly emerging target in the progression of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Therefore, molecular imaging probes capable of imaging noninvasively Pgp and closely related transporter activities in tissues as well as tumors would be expected to contribute to personalized medicine. Interrogation of Pgp-mediated transport activity in vivo via noninvasive SPECT imaging could be beneficial for stratification of patient populations likely to benefit from a given therapeutic treatment, assist in the management of chemotherapy and aid the study of neurodegenerative diseases.
Fabrication of a Novel Bioceramic Membrane for Guided Bone Regeneration (2006)

In guided bone regeneration (GBR) technique, a barrier membrane is placed over the alveolar bone defect to prevent the down-growth of cells. However, the conventional membrane has no adhesive property for the tissue. This study challenged to develop a GBR membrane that has easily well adhesion to periodontal tissue with biocompatibility.
High Dielectric Constant Polymer Film Capacitors (PREPRINT) (2010)

Abstract : Pulse-forming networks (PFNs) are critical for many pulsed power applications; they perform conversion of prime electric energy into short pulses needed to energize large loads. They require high energy density, fast discharge speed (milliseconds to nanoseconds) capacitors. Medical defibrillators also require high performance capacitors that can deliver pulsed energy to the patient heart in approximately 5 milliseconds at 800 volts (implantable) or over 2,000 volts (external). Current commercial electrostatic capacitors usually have an energy density well below 3 J/cc due to the limitation of dielectric material performance and reliability constraints. The capacitors usually occupy a large fraction of the volume and contribute to the major cost in both the PFNs. The bulky size of capacitor components severely impedes the miniaturization of many electronic devices. The energy density (UE) of a linear dielectric material is proportional to its dielectric constant (K) and the square of its dielectric breakdown strength (DBS). Therefore, high K and DBS are critical to achieve a high energy density in capacitors. DBS is determined by both intrinsic and extrinsic (process-related) factors, but there is a general consensus that except for very thin films deposited on a substrate, the breakdown in practical components is limited by defects introduced during film processing. There have been many improvements over the last 10 to 20 years in polymer resin purity, capacitor film quality, metallization design, and capacitor fabrication so that energy densities of 1 to 3 J/cubic cm are now available with predictable lifetime for mission critical applications. It is uncertain if more process improvements can be expected to yield further energy density. In this paper, we present our recent progress in the development of high-K polymer dielectric materials, the commercial scale production of high-quality capacitor film, and the test of our first generation prototype capacitors.
HLA Phenotype and Cytokine-Induced Tumor Control in Advanced Renal Cell Cancer (2001)

Our data underline the pivotal role of the MHC complex in controlling and regulating the cellular immune response in renal cell cancer. We could identify HLA antigens, which correlate with response to cytokine-treatment, with a long-lasting effective tumor control and prolonged overall survival.
Miniature Wireless Photoplethysmography Devices: Integration in Garments and Test Measurements (2012)

Wireless PPG devices were developed and embedded in everyday clothes (bandage, scarf, cycling glove and wrist strap) to monitor cardiovascular state of free-moving persons. The corresponding software for measurements also has been developed and tested in laboratory. Real-time measurements of PPG signals were taken in parallel with a professional ECG reference device, and high correlation was demonstrated.
Twinning in cattle: I. Foundation animals and genetic and environmental effects on twinning rate. (1990)

Foundation cows were selected using prior records from one of two sources, private herds or other projects at the Research Center. Comparing twinning rates before and after selection, the repeatability was lower for those from the first (.08) than for those from the second (.16) source with a combined value of .12. Realized heritability of single-parity twinning rate estimated from selection of parents and response in daughters of foundation females was .06. Paternal half-sib estimate of heritability of twinning rate was .02 +/- .07. Estimates of repeatability computed from calving records of females born in the project indicate that permanent environmental effects on twinning rate in cattle are small. Mean calving rate of females born in the project was 1.11 in the data set that included all data and 1.09 in the data set that excluded females from highly selected parents. Twinning rate was greater (P less than .05) in fall than in spring calving (1.13 vs 1.06). Data on twinning rate of a sample of the Swedish Friesian breed were summarized. Mean twinning rate of the Swedish Friesian breed is 2.57%. Age adjusted mean twinning rate of daughters of 32 half-sib sons of one particular Swedish Frieisan sire averaged 5.4% and ranged from .9% to 13.6%. There was no indication of a bimodal distribution, which would be expected if a single gene with a major effect on twinning rate were segregating. The estimated genetic standard deviation (sigma-xn) for mean twinning rates of the 32 sire progeny groups was 1.8%. Observed range among son progenies was .127 or 7.2 sigma-xn, in reasonable agreement with the hypothesis that twinning rate in this population is inherited as a quantitative trait.
Fast PCR Thermal Cycling Device (2008)

A novel flow-through device for performing fast PCR thermal cycling is presented. The thermal gradient thermal cycling device is comprised of layers of highly thermally conducting material separated by insulating layers. Channels etched in the conducting and insulating layers create one continuous path through the device. When the device is held between platens at different temperatures and PCR sample mix is pumped through it, every fluid particle undergoes the time-temperature protocol necessary for PCR but with a temperature change rate not possible with conventional cyclers. Ultrafast thermal cycling makes it ideal for bio-defense applications, such as the instantaneous bio-aerosol agent identification system under development for the Department of Homeland Security. Its compact size and simplicity of use make it a natural choice for diagnostics, forensics, food and water testing and other DNA testing applications. Herein we describe the design and fabrication of the device developed for IBADS and the subsequent performance with various assays using plasmid and genomic template DNA. Performance under some circumstances was exceptional: Amplification rates of up to two decades per minute were recorded and total amplification of up to eight decades in 30 cycles was seen. We discuss how to optimize the performance of a device that pushes PCR to its fundamental limits and review a wide variety of performance data.
Cost-effective treatment of women with advanced ovarian cancer by cytoreductive surgery and chemotherapy directed by an in vitro assay for drug resistance. (1999)

Because of the high recurrence rate and the poor long-term survival of women with advanced ovarian cancer, improved therapies for this disease are needed. After surgical debulking, we used results of an in vitro assay for drug resistance to individually select chemotherapy for the patients in this study. Although the 3-year survival of 69% obtained in the present study appears good compared with previously published studies of optimally debulked patients, the results must be viewed with caution. Patients were not randomized, and differences in prognostic factors, such as tumor grade, patient age, and performance status, could account in part for the higher survival found in the current study compared with previously published studies. Treatment with either CP or TP resulted in equivalent 3-year survival. The cost to achieve 3-year survival with this protocol, including the cost of the drug resistance assay, was $9768. We believe that consideration of costs avoided by the elimination of ineffective treatments, needless toxicity, and loss of quality of life would likely increase the cost-effectiveness of assay-directed therapy compared with conventional therapy. This study demonstrates that it is feasible to use an in vitro assay in routine clinical practice to eliminate ineffective chemotherapeutic agents.
N-terminal amino acid sequence of Bacillus licheniformis alpha-amylase: comparison with Bacillus amyloliquefaciens and Bacillus subtilis Enzymes (1982)

The thermostable, liquefying alpha-amylase from Bacillus licheniformis was immunologically cross-reactive with the thermolabile, liquefying alpha-amylase from Bacillus amyloliquefaciens. Their N-terminal amino acid sequences showed extensive homology with each other, but not with the saccharifying alpha-amylases of Bacillus subtilis.
Rapid synthesis of oligodeoxyribonucleotides on a grafted polymer support (1979)

Rapid synthesis of oligodeoxyribonucleotides is described by a solid phase method. Polysterene grafted on the surface of polytetrafluoroethylene has been found to be an adequate support. The properties of the support were studied in the synthesis of a number of oligonucleotides 6 to 15 nucleotides long. A flow-type semi-automatic synthesizer has been used. Each nucleotide addition involves seven steps and takes 8 hours. Oligonucleotide isolated and purified by ion-exchange chromatography amounts to 1-3 mumol per gram of support.
Violet and Near-UV Light Emission from GaN/Al<sub> 0.08</sub>Ga<sub> 0.92</sub>N Injection Diode Grown on (0001) 6H-SiC Substrate by Low-Pressure Metal-Organic Vapor Phase Epitaxy (1995)

GaN/Al 0.08 Ga 0.92 N double-heterostructure (DH) was grown on (0001)-oriented 6H-SiC substrate by low-pressure metal-organic vapor phase epitaxy (LP MO-VPE). The main peak wavelength at room temperature from GaN/Al 0.08 Ga 0.92 N DH injection diode was 420 nm which originated in the band-to-impurity transition in GaN. A weak peak at 360 nm was also observed.
Retardation of Atherosclerosis by Overexpression of Catalase or Both Cu/Zn-Superoxide Dismutase and Catalase in Mice Lacking Apolipoprotein E (2004)

Oxidative stress has been suggested to potentiate atherogenesis. However, studies that have investigated the effect of antioxidants on atherosclerosis showed inconsistent results, ie, atherosclerosis was either retarded or not changed by dietary antioxidants. This report directly examined the effect of overexpressing Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and/or catalase on atherosclerosis and lipid peroxidation in mice lacking apolipoprotein E (ApoE-/-). Based on lipid staining of the en face of the aorta tree and the serial sections of the proximal aorta, ApoE-/- mice overexpressing catalase or both Cu/Zn-SOD and catalase had smaller and relatively early stages of atherosclerotic lesions (eg, foam cells and free lipids) when compared with ApoE-/- mice, who developed more advanced lesions (eg, fibrous caps and acellular areas). In addition, the retarded development of atherosclerosis was correlated with a reduced F2-isoprostanes in the plasma and aortas in ApoE-/- mice overexpressing catalase or both Cu/Zn-SOD and catalase. In contrast, the levels of F2-isoprostanes and atherosclerosis in the ApoE-/- mice overexpressing Cu/Zn-SOD alone were comparable to ApoE-/- control mice. These observations implied that endogenously produced hydrogen peroxide, but not superoxide anions, contributed to the formation of oxidized lipids and the development of atherosclerosis in ApoE-/- mice.
Synthesis, crystal structure, photoluminescence properties of organic-inorganic hybrid materials based on ethylenediamine bromide (2019)

In this work, a new orthorhombic organic-inorganic hybrid single crystal (C2H10N2)2MnBr4.2Br with-Zero-dimensional structure was synthesized by slow evaporation method at 75 °C. The crystal structure and intermolecular interactions were performed by single crystal X-ray diffraction and Hirshfeld surface. Optical properties of (C2H10N2)2MnBr4.2Br were systematically studied by Raman, infrared spectrum, UV–vis, photoexcitation spectra, and photoluminescence spectra. The optical band gap (Eg = 2.61 eV) were calculated from the absorption spectra of (C2H10N2)2MnBr4.2Br. This hybrid materials also had shown good thermal stability (decomposition temperature: 288–660 °C). Finally, photoluminescence measurements showed a strong excitation line at 362 nm and a strong fluorescence at 537 nm which makes it a promising material in luminescence field.
<i>Arabidopsis</i> TARGET OF RAPAMYCIN Interacts with RAPTOR, Which Regulates the Activity of S6 Kinase in Response to Osmotic Stress Signals (2005)

TARGET OF RAPAMYCIN (TOR) kinase controls many cellular functions in eukaryotic cells in response to stress and nutrient availability and was shown to be essential for embryonic development in Arabidopsis thaliana. We demonstrated that Arabidopsis RAPTOR1 (a TOR regulatory protein) interacts with the HEAT repeats of TOR and that RAPTOR1 regulates the activity of S6 kinase (S6K) in response to osmotic stress. RAPTOR1 also interacts in vivo with Arabidopsis S6K1, a putative substrate for TOR. S6K1 fused to green fluorescent protein and immunoprecipitated from tobacco (Nicotiana tabacum) leaves after transient expression was active in phosphorylating the Arabidopsis ribosomal S6 protein. The catalytic domain of S6K1 could be phosphorylated by Arabidopsis 3-phosphoinositide-dependent protein kinase-1 (PDK1), indicating the involvement of PDK1 in the regulation of S6K. The S6K1 activity was sensitive to osmotic stress, while PDK1 activity was not affected. However, S6K1 sensitivity to osmotic stress was relieved by co-overexpression of RAPTOR1. Overall, these observations demonstrated the existence of a functional TOR kinase pathway in plants. However, Arabidopsis seedlings do not respond to normal physiological levels of rapamycin, which appears to be due its inability to bind to the Arabidopsis homolog of FKBP12, a protein that is essential for the binding of rapamycin with TOR. Replacement of the Arabidopsis FKBP12 with the human FKBP12 allowed rapamycin-dependent interaction with TOR. Since homozygous mutation in TOR is lethal, it suggests that this pathway is essential for integrating the stress signals into the growth regulation.
Fomitopsis betulina (formerly Piptoporus betulinus): the Iceman’s polypore fungus with modern biotechnological potential (2017)

Higher Basidiomycota have been used in natural medicine throughout the world for centuries. One of such fungi is Fomitopsis betulina (formerly Piptoporus betulinus), which causes brown rot of birch wood. Annual white to brownish fruiting bodies of the species can be found on trees in the northern hemisphere but F. betulina can also be cultured as a mycelium and fruiting body. The fungus has a long tradition of being applied in folk medicine as an antimicrobial, anticancer, and anti-inflammatory agent. Probably due to the curative properties, pieces of its fruiting body were carried by Ötzi the Iceman. Modern research confirms the health-promoting benefits of F. betulina. Pharmacological studies have provided evidence supporting the antibacterial, anti-parasitic, antiviral, anti-inflammatory, anticancer, neuroprotective, and immunomodulating activities of F. betulina preparations. Biologically active compounds such as triterpenoids have been isolated. The mushroom is also a reservoir of valuable enzymes and other substances such as cell wall (1→3)-α-D-glucan which can be used for induction of microbial enzymes degrading cariogenic dental biofilm. In conclusion, F. betulina can be considered as a promising source for the development of new products for healthcare and other biotechnological uses.