gebhart/patrepeval huggingface dataset:
Efficient Authentication and Authorization of Mobile Users Based on Peer-to-Peer Network Mechanisms (2005)

This paper presents a peer-to-peer based authentication and authorization infrastructure to minimize authentication delays when mobile users roam across different wireless networks. The basic idea is to avoid exchanging security information between networks visited by a roaming user and the user's home authentication, authorization, and accounting (AAA) server that is typically located in the home network possibly far away from the visited network. Instead, authentication and authorization of a roaming user shall be supported by an AAA server in the visited network. We propose that the AAA server that is responsible for authentication and authorization in a newly visited network locates the AAA server in the previously visited network and retrieves the required security information from that AAA server. The AAA servers can be organized in a peer-to-peer manner and peer-to-peer mechanisms can be applied for searching and transferring security information between them. We propose several mechanisms for quickly locating the previously responsible AAA server in order to decrease authentication delays. The performance of these mechanisms is evaluated by simulations. Real performance measurements show the rather low performance overhead of application level forwarding used in peer-to-peer networks.
IL-4 Haplotype -590T, -34T and Intron-3 VNTR R2 Is Associated with Reduced Malaria Risk among Ancestral Indian Tribal Populations (2012)

Our study suggests that the IL-4 polymorphisms regulate host susceptibility to malaria and disease progression. TTR2 haplotype, which gives protection against malaria, is high among ATPs. Since they inhabited in isolation and mainly practice hunter-gatherer lifestyles and exposed to various parasites, IL-4 TTR2 haplotype might be under positive selection.
Immunohistochemical mapping of brain triiodothyronine reveals prominent localization in central noradrenergic systems (1996)

Many lines of evidence support a close association between thyroid hormones and noradrenergic systems in peripheral tissues. However, there is little certainty regarding interactions of the two systems in brain. We now report that triiodothyronine is concentrated in both nuclei and projection sites of central noradrenergic systems. Immunohistochemical mapping of the hormone revealed the following: (1) Locus coeruleus and all other noradrenergic cell groups identified were the most prominently labeled neural centers in the brain. (2) The hormone was also concentrated in the widely dispersed targets of noradrenergic projections. (3) Triiodothyronine labeling in noradrenergic target cells was most prominent over the cell nuclei, indicating that the hormone was bound to its receptors. Therefore, targets of noradrenergic innervation should be responsive to triiodothyronine. (4) Unlike that in noradrenergic target cells, triiodothyronine staining was decidedly perikaryal in locus coeruleus (A-6) and the other A-1 to A-7 cell groups; the staining pattern in locus coeruleus cytosol and processes was heavy, clumped and similar to that seen in contiguous sections immunostained for tyrosine hydroxylase. Results of radio-immunoassay, immunoabsorption and pharmacological tests demonstrated the specificity of the antibody for triiodothyronine and ruled against cross-reactivity with norepinephrine or its metabolites as the basis for the staining reactions. Although other possibilities consistent with these new observations are given consideration, it appears that the structure and activity of central noradrenergic systems may be major determinants of triiodothyronine distribution patterns and actions in brain. If the noradrenergic system processes both triiodothyronine and norepinephrine and conducts them both to nerve cell groups receiving its terminal arborizations, specific postsynaptic receptors would be available for transduction of both sets of messages. The evidence provides a morphological basis for earlier proposals that triiodothyronine may play a neuromodulatory or neurotransmitter role in the adrenergic nervous system.
Hematopoietic cells and radioresistant host elements influence natural killer cell differentiation. (1993)

Radioresistant host elements mediate positive selection of developing thymocytes, whereas bone marrow-derived cells induce clonal deletion of T cells with receptors that are strongly autoreactive. In contrast to T cell development, little is known about the elements governing the natural killer (NK) cell repertoire, which, similar to the T cell repertoire, differs between individuals bearing different major histocompatibility complex (MHC) phenotypes. We have used murine bone marrow transplantation models to analyze the influence of donor and host MHC on an NK cell subset. We examined the expression of Ly-49, which is strongly expressed on a subpopulation of NK cells of H-2b mice, but not by NK cells of H-2a mice, probably because of a negative effect induced by the interaction of Ly-49 with Dd. To evaluate the effect of hematopoietic cell H-2a expression on Ly-49 expression of H-2b NK cells, we prepared mixed allogeneic chimeras by administering T cell-depleted allogeneic (B10.A, H-2a) and host-type (B10, H-2b) marrow to lethally irradiated B10 mice, or by administering B10. A marrow to B10 recipients conditioned by a nonmyeloablative regimen. Expression of H-2a on bone marrow-derived cells was sufficient to downregulate Ly-49 expression on both H-2a and H-2b NK cells. This downregulation was thymus independent. To examine the effect of H-2a expressed only on radioresistant host elements, we prepared fully allogeneic chimeras by administering B10 bone marrow to lethally irradiated B10.A recipients. B10 NK cells of these fully allogeneic chimeras also showed downregulation of Ly-49 expression. The lower level of H-2a expressed on H-2b x H-2a F1 cells induced more marked downregulation of Ly-49 expression on B10 NK cells when presented on donor marrow in mixed chimeras than when expressed only on radioresistant host cells. Our studies show that differentiation of NK cells is determined by interactions with MHC molecules expressed on bone marrow-derived cells and, to a lesser extent, by MHC antigens expressed on radioresistant host elements.
Quantum cascade lasers with monolithic air–semiconductor Bragg reflectors (2000)

Electrically pumped GaAs/AlGaAs quantum cascade lasers with monolithic one-dimensional photonic-band gap mirrors are presented. The mirrors consist of two, precisely defined grooves trenched across the laser ridge using a focused ion beam. A substantial improvement of the laser performance is achieved due to the increased reflectivity of these mirrors. A decrease of the threshold current by 40% at 150 K is observed. The maximum operation temperature increases from 155 K for an unmodified laser to 170 K for the laser with the modified mirrors, and an increase of the T0 parameter from 99 to 114 K is found.
Towards a shape model of white matter fiber bundles using diffusion tensor MRI (2005)

White matter fiber bundles of the human brain form a spatial pattern defined by the anatomical and functional architecture. Human brain atlases provide names for individual tracts and document that these patterns are comparable across subjects. Tractography applied to the tensor field in diffusion tensor imaging (DTI) results in sets of streamlines which can be associated with major fiber tracts. Comparison of fiber tract properties across subjects requires comparison at corresponding anatomical locations. As an alternative to linear and nonlinear registration of DTI images and voxel-based analysis, we propose a novel methodology that models the shape of white matter tracts. A clustering uses similarity of adjacent curves and an iterative processing scheme to group sets of curves to bundles and to reject outliers. Unlike previous work which models fiber tracts as sets of curves centered around a spine, we extend the notion of bundling towards a more general representation of manifolds. We describe tracts, represented as sets of curves of similar shape, by a shape prototype swept along a space trajectory. This approach can naturally describe white matter structures observed either as bundles dispersing towards the cortex or tracts defined as dense patterns of parallel fibers forming manifolds. Curves are parameterized by arc-length and represented by intrinsic local shape properties (curvature and torsion). Feasibility is demonstrated by modeling the left and right cortico-spinal tracts and a part of the transversal callosal tract.
APPENDIX: Some Properties of DNP-Amines* (1961)

Journal Article APPENDIX: Some Properties of DNP-Amines Get access ATSUSHI OIKAWA, ATSUSHI OIKAWA Institute for Cancer Research, Osaka University Medical SchoolOsaka Search for other works by this author on: Oxford Academic PubMed Google Scholar SADAO NOGUCHI, SADAO NOGUCHI Institute for Cancer Research, Osaka University Medical SchoolOsaka Search for other works by this author on: Oxford Academic PubMed Google Scholar TAIJIRO MATSUSHIMA, TAIJIRO MATSUSHIMA Institute for Cancer Research, Osaka University Medical SchoolOsaka Search for other works by this author on: Oxford Academic PubMed Google Scholar MASAYORI INOUYE MASAYORI INOUYE Institute for Cancer Research, Osaka University Medical SchoolOsaka Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 50, Issue 2, August 1961, Pages 157–158, https://doi.org/10.1093/oxfordjournals.jbchem.a127423 Published: 01 August 1961 Article history Received: 13 March 1961 Published: 01 August 1961
Synthesis of functionalized bicyclo[3.2.1]octa-2,6-dienes by thermal rearrangement of substituted 6-<i>exo</i>-(1-alkenyl)bicyclo[3.1.0]hex-2-ene systems (1987)

Thermolysis of each of the enol silyl ethers 31–35 affords, cleanly and efficiently, the bicyclo[3.2.1]octadienes 36–40, respectively. Similarly, thermal rearrangement of the enol silyl ether 50 provides the diene 51. Hydrolysis of 36, 37, and 39, and decarbomethoxylation of the resultant keto esters 41, 42, and 44, gives the ketones 46–48, respectively. The ketone 46 is also obtained by acid hydrolysis of 51. Conversion of 6-methyl-1-hepten-4-yn-3-ol (56) into the enol ether 63 is described. Thermolysis of 63 gives 64, which, upon acid hydrolysis, affords 65. Thermolysis of the enones 68 and 69 produces the bicyclic dienones 70 and 71, respectively. On the other hand, thermolysis of 73 and 74, derived from the enone 69, provides the C-8 exo substituted bicyclo[3.2.1]octa-2,6-dienes 75 and 76, which are transformed smoothly, by acid hydrolysis, into the ketones 77 and 78, respectively.
[The expression of tumor necrosis factor related apoptosis induce ligand in human laryngeal squamous cell carcinoma]. (2006)

TRAIL receptors expression is generally expressed in human LSCC and LNT. The expression level of TRAIL receptors is various, which may explain the anti-cancer effect of TRAIL. The TRAIL receptor DcR1, DcR2 may play an important role in the apoptosis regulation of LSCC.
Human anti-FcεRIα autoantibodies isolated from healthy donors cross-react with tetanus toxoid (1999)

Natural antibodies (Ab) reacting with self antigens have been shown to be present in all individuals. These autoantibodies (auto-Ab) can be either pathogenic or non-pathogenic. Auto-Ab reacting with the α-subunit of the high-affinity receptor for IgE (FcϵRIα) have been implicated in the pathogenesis of a subset of patients with chronic idiopathic urticaria (CIU). Intravenous immunoglobulin (IVIg) preparations have been used with variable clinical benefit in the treatment of these patients. Here we show that anti-FcϵRIα auto-Ab are present in a therapeutic IVIg preparation as well as in atopic and chronic urticaria patients and healthy individuals. We affinity-purified the anti-FcϵRIα Ab from an IVIg preparation using recombinant FcϵRIα. Interestingly, these anti-FcϵRIα auto-Ab showed no evidence of histamine release but strongly cross-reacted with an external antigen, tetanus toxoid (TTd) with a higher affinity for TTd than for the FcϵRIα. Since the cross-reacting Ab are non-anaphylactogenic, there is no evidence that TTd immunization may contribute to the pathogenesis of CIU. However, our results may indicate that the anti-FcϵRIα auto-Ab belong to the natural Ab and serve as the parental Ab for some anti-TTd Ab.
Masters of Memory (2007)

This paper discusses Innovative Silicon's development of the densest and cheapest embedded technology in the world which is called Z-RAM, for zero-capacitor dynamic random access memory. If Z-RAM grabs even a little piece of the on-chip memory market, it will change the ground rules for microprocessor design and quickly make Innovative Silicon a company to be reckoned with. This development is considered to be a success, because its technology could quintuple the amount of memory incorporated into microprocessor chips and make them both cheaper and faster
Computer code for estimating installed performance of aircraft gas turbine engines. Volume 3: Library of maps (1979)

A computerized method which utilizes the engine performance data and estimates the installed performance of aircraft gas turbine engines is presented. This installation includes: engine weight and dimensions, inlet and nozzle internal performance and drag, inlet and nacelle weight, and nacelle drag. The use of two data base files to represent the engine and the inlet/nozzle/aftbody performance characteristics is discussed. The existing library of performance characteristics for inlets and nozzle/aftbodies and an example of the 1000 series of engine data tables is presented.
Effects of N-(4-hydroxyphenyl)retinamide supplementation on vitamin A metabolism. (1994)

The efficacy of the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) has been demonstrated in the inhibition of cancers in a variety of tissues. Moreover, toxicity effects following administration of 4-HPR have been found to be reduced or absent when compared to other retinoids. Pharmacokinetic studies in both animals and humans have focused on the metabolism of 4-HPR and its metabolites, and relatively little information has been published detailing the effects of long-term administration of 4-HPR upon normal endogenous vitamin A metabolism. Thus, the present study was carried out to examine the effects of long-term administration of 4-HPR upon plasma and tissue vitamin A kinetics. Male Sprague-Dawley rats were fed either a control diet sufficient in vitamin A [CON group; 1.0 retinol (ROH) equivalents/g diet] or a CON diet supplemented with 4-HPR (CON+4HPR group; 1173 micrograms 4-HPR/g diet). Following i.v. injection of a physiologically radiolabeled dose of ROH, ROH tracer and tracee kinetics were monitored in plasma and tissues over a 41-day period. Kinetic parameters were determined using the SAAM/CONSAM computer modeling programs to carry out graphical analysis of the tracer concentration curves. Mean plasma ROH levels measured for the CON+4HPR group were reduced to one-third of those of the CON group. Most of the kinetic parameters calculated were found to be significantly altered by the inclusion of 4-HPR in the diet. The fraction of the plasma ROH being catabolized per day (fractional catabolic rate) was nearly twice as high in the CON+4HPR treated group (3.61 +/- 0.49 day-1; mean +/- SD) as compared to the CON group (2.00 +/- 0.68 day-1). The amount of time that vitamin A molecules spent in the body before being lost irreversibly from the system (system residence time) was decreased by half in the CON+4HPR group (19.20 +/- 7.13 days) versus the CON group (38.63 +/- 9.62 days). Despite the increased catabolic rates and decreased system residence times measured for the CON+4HPR group, the estimated vitamin A use in these animals (11.01 +/- 3.10 micrograms/day) was 33% less than that used by the CON group (16.31 +/- 2.47 micrograms/day). Studies investigating the mechanisms by which 4-HPR alters vitamin A kinetics are presently under way in our laboratory. Nevertheless, these results suggest that long-term administration of 4-HPR markedly perturbs normal vitamin A metabolism in rats. Whether 4-HPR similarly alters human vitamin A metabolism with untoward clinical consequences deserves careful evaluation.
Quaternization of poly(tertiary aminostyrene)s and characterization of the quaternized polymers (1997)

The Menschutkin reaction of three poly(tertiary aminostyrene)s: poly(N,N-dimethyl-4-vinylphenylamine) (PPA), poly(N,N-dimethyl-4-vinylbenzylamine) (PBA), and poly(N,N-dimethyl-4-vinylphenethylamine) (PPTA) was investigated. These three polymers having narrow molecular weight distributions were prepared via anionic living polymerization. PPA reacted homogeneously with n-butyl bromide in N,N-dimethylformamide (DMF). PBA and PPTA also reacted homogeneously with n-butyl bromide in a mixture of DMF/methanol (75/25 v/v %). GPC measurement of the quaternized polymers was carried out using a mixture of water/acetonitrile (80/20 v/v %) containing 0.5M acetic acid and 0.3M sodium sulfate (pH = 2.9) as an eluant in order to suppress adsorption of the quaternized water soluble polymers on GPC gel. Results of GPC measurement indicate that the polymer chains of the three poly(tertiary aminostyrene)s are neither severed nor crosslinked in the process of quaternization. Temperature dependence and reaction time dependence on the degree of quaternization (DQ) were studied for PPT, PBA, and PPTA. By altering reaction time and temperature, the DQ values of the three poly(tertiary aminostyrene)s could be controlled in the range from 0% to nearly 100%. Quaternization reactivity of the amino groups in the three polymers was found to decrease in the order, PPTA, PBA, and PPA. The differences in reactivity are thought to be attributable to the electron density on the nitrogen atom of the N,N-dimethylamino group, and steric hindrance in the vicinity of the nitrogen atom. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35: 1219–1226, 1997
Clustering Based on Conditional Distributions in an Auxiliary Space (2002)

We study the problem of learning groups or categories that are local in the continuous primary space but homogeneous by the distributions of an associated auxiliary random variable over a discrete auxiliary space. Assuming that variation in the auxiliary space is meaningful, categories will emphasize similarly meaningful aspects of the primary space. From a data set consisting of pairs of primary and auxiliary items, the categories are learned by minimizing a Kullback-Leibler divergence-based distortion between (implicitly estimated) distributions of the auxiliary data, conditioned on the primary data. Still, the categories are defined in terms of the primary space. An online algorithm resembling the traditional Hebb-type competitive learning is introduced for learning the categories. Minimizing the distortion criterion turns out to be equivalent to maximizing the mutual information between the categories and the auxiliary data. In addition, connections to density estimation and to the distributional clustering paradigm are outlined. The method is demonstrated by clustering yeast gene expression data from DNA chips, with biological knowledge about the functional classes of the genes as the auxiliary data.
The Prediction of Tertiary Structure of RNA Based upon Secondary Structure by Using the Relaxation Method and Texture Mapping Method (2013)

In this paper, we propose a method to predict tertiary structure of an RNA sequence. Our prediction method would first find the secondary structure of the given RNA sequence. We then use the relaxation method to predict the 3-space structure of it. Experimental results show that our method is quite feasible. We tested our approach on 731 RNA's. 179 of them got a complete match, 391 of them got 90% match and 161 of them got 80% match.
Data Modeling for Developing the Baseline Network Analysis Software of Korean EMS System (2009)

This paper summarizes a data modeling for developing the baseline network analysis software of the Korean energy management system (EMS). The study is concentrated on the following aspects. First, the data for operating the each application software are extracted. Some of the EMS network application softwares are selected for basis model. Those are based on the logical functions of each software and are not considered the other softwares. Second, the common data are extracted for equipment model and topological structure of power system in Korea. We propose the application common model(ACM) that can be applied whole EMS network application softwares. The ACM model includes the hierarchy and non-hierarchy power system structure, and is connected each other using the direct and indirect link. Proposed database model is tested using the Korea Electric Power Corporation(KEPCO) system. The real time SCADA data are provided for the test. Through the test, we verified that the proposed database structure can be effectively used to accomplish the Korean EMS system.
Heat Transfer During Quenching by Plate Roller Quenching Machine (2013)

For plate quenching on a roller quenching machine, heat transfer process is investigated. According to the practical online experiment of plate center temperature, average heat transfer coefficient under different conditions and temperature fields are analyzed by numerical simulation. The results show that, at the water temperature of 15 ℃, the instantaneous maximum quenching cooling rate is 17.6 ℃/s for the plate of 50 mm in thickness in roller quenching process. In the temperature range of 400-850 ℃, the maximum is 12.1 ℃/s. With the plate surface temperature decreasing, surface heat transfer coefficient increases at first, and reaches the maximum value of about 15 000 W/(m~2·K), and then decreases. The calculated heat transfer coefficients are applied to analyze plate temperature field of different thicknesses, and the difference between the calculated and measured temperature is less than 5%.
Encapsulated VEGF-Secreting Cells Enhance Proliferation of Neuronal Progenitors in the Hippocampus of AβPP/Ps1 Mice (2012)

Vascular endothelial growth factor (VEGF) promotes neurogenesis in the adult hippocampus, but the way in which this process occurs in the Alzheimer's disease (AD) brain is still unknown. We examined the proliferation of neuronal precursors with an ex vivo approach, using encapsulated VEGF secreting cells, in AβPP/PS1 mice, a mouse model of AD. Overexpression of VEGF and VEGF receptor flk-1 was observed in the cerebral cortex from VEGF microcapsules-treated AβPP/PS1 mice at 1, 3 and 6 months after VEGF-microcapsule implantation. Stereological counting of 5-bromodeoxyuridine positive cells revealed that encapsulated VEGF secreting cells significantly enhanced cellular proliferation in the hippocampal dentate gyrus (DG). The number of neuronal precursors in VEGF microcapsules-treated AβPP/PS1 mice was also greater, and this effect remains after 6 months. We also confirmed that encapsulated VEGF secreting cells also stimulated angiogenesis in the cerebral cortex and hippocampal dentate gyrus. In addition, we found that VEGF-microcapsule treatment was associated with a depressed expression and activity of acetylcholinesterase in the hippocampus of AβPP/PS1 mice, a similar pattern as first-line medications for the treatment of AD. We conclude that stereologically-implanted VEGF-microcapsules exert an acute and long-standing neurotrophic effects, and could be utilized to improve potential therapies to control the progression of AD.