gebhart/patrepeval huggingface dataset:
Improved Music Perception with Explicit Pitch Coding in Cochlear Implants (2005)

Music perception and appraisal is very poor in cochlear implant (CI) subjects partly because (musical) pitch is inadequately transmitted by the current clinically used sound processors. A new sound processing scheme (F0mod) was designed to optimize pitch perception, and its performance for music and pitch perception was compared in four different experiments to that of the current clinically used sound processing scheme (ACE) in six Nucleus CI24 subjects. In the F0mod scheme, slowly varying channel envelopes are explicitly modulated sinusoidally at the fundamental frequency (F0) of the input signal, with 100% modulation depth and in phase across channels to maximize temporal envelope pitch cues. The results of the four experiments show that: (1) F0 discrimination of single-formant stimuli was not significantly different for the two schemes, (2) F0 discrimination of musical notes of five instruments was three times better with the F0mod scheme for F0 up to 250 Hz, (3) melody recognition of familiar Flemish songs (with all rhythm cues removed) was improved with the F0mod scheme, and (4) estimates of musical pitch intervals, obtained in a musically trained CI subject, matched more closely the presented intervals with the F0mod scheme. These results indicate that explicit F0 modulation of the channel envelopes improves music perception in CI subjects.
Bone Marrow–Derived Cells for Enhancing Collateral Development (2004)

Initial animal studies of single angiogenic agents, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), generated enthusiasm for the concept that these agents might enhance collateral development and thereby provide alternative therapies for patients with vascular disease not amenable to traditional revascularization. The enthusiasm, apparently justified by the subsequent results of small nonrandomized phase-I clinical trials, was then tempered by the subsequent disappointing results of randomized clinical trials. In light of these disappointing results, investigators have pursued alternative strategies in an attempt to improve tissue perfusion. One such strategy is the utilization of bone marrow-derived cell therapy. This review discusses mechanistic pathways mediating the effects of such cell therapy, summarizes the animal and early clinical experience, and speculates on the potential of genetic manipulation of bone marrow-derived cells in an attempt to further enhance their potency.
Phosphorus-Bridged <i>ansa</i>-Metallocene Complexes of Titanium, Zirconium, and Hafnium:  The Syntheses and Structures of [PhP(C<sub>5</sub>Me<sub>4</sub>)<sub>2</sub>]MX<sub>2</sub> and [Ph(E)P(C<sub>5</sub>Me<sub>4</sub>)<sub>2</sub>]MX<sub>2</sub> (E = O, S, Se) Derivatives (1998)

A series of phosphorus-bridged ansa-metallocene complexes of titanium, zirconium, and hafnium, [PhP(C5Me4)2]MX2 and [Ph(E)P(C5Me4)2]MX2 (X = Cl, Me, CO, (Se3)0.5, (Te3)0.5; E = O, S, Se), has been synthesized. Structural characterization by X-ray diffraction indicates that, in comparison to their non-ansa counterparts (C5Me5)2MX2, the cyclopentadienyl groups in phosphorus-bridged complexes are displaced from symmetric η5-coordination toward η3-coordination. Such η3,η3-coordination creates more electrophilic metal centers than those in their permethylcyclopentadienyl counterparts, as judged by the ν(CO) stretching frequencies of the zirconium dicarbonyl complexes Cp*2Zr(CO)2 (1946 and 1853 cm-1) and [PhP(C5Me4)2]Zr(CO)2 (1959 and 1874 cm-1).
The Use of Systolic Time Intervals as an Assessment of Left Ventricular Function in Acute Myocardial Infarction (1971)

Conference Abstract| June 01 1971 The Use of Systolic Time Intervals as an Assessment of Left Ventricular Function in Acute Myocardial Infarction E. D. Bennett; E. D. Bennett 1Institute of Cardiology, London, W.1 Search for other works by this author on: This Site PubMed Google Scholar C. S. Smithen; C. S. Smithen 1Institute of Cardiology, London, W.1 Search for other works by this author on: This Site PubMed Google Scholar G. E. Sowton G. E. Sowton 1Institute of Cardiology, London, W.1 Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd © 1971 The Biochemical Society and the Medical Research Society1971 Clin Sci (1971) 40 (6): 24P–25P. https://doi.org/10.1042/cs040024Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation E. D. Bennett, C. S. Smithen, G. E. Sowton; The Use of Systolic Time Intervals as an Assessment of Left Ventricular Function in Acute Myocardial Infarction. Clin Sci 1 June 1971; 40 (6): 24P–25P. doi: https://doi.org/10.1042/cs040024Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1971 The Biochemical Society and the Medical Research Society1971 Article PDF first page preview Close Modal You do not currently have access to this content.
Functional expression of sodium-glucose transporters in cancer (2015)

Glucose is a major metabolic substrate required for cancer cell survival and growth. It is mainly imported into cells by facilitated glucose transporters (GLUTs). Here we demonstrate the importance of another glucose import system, the sodium-dependent glucose transporters (SGLTs), in pancreatic and prostate adenocarcinomas, and investigate their role in cancer cell survival. Three experimental approaches were used: (i) immunohistochemical mapping of SGLT1 and SGLT2 distribution in tumors; (ii) measurement of glucose uptake in fresh isolated tumors using an SGLT-specific radioactive glucose analog, α-methyl-4-deoxy-4-[(18)F]fluoro-D-glucopyranoside (Me4FDG), which is not transported by GLUTs; and (iii) measurement of in vivo SGLT activity in mouse models of pancreatic and prostate cancer using Me4FDG-PET imaging. We found that SGLT2 is functionally expressed in pancreatic and prostate adenocarcinomas, and provide evidence that SGLT2 inhibitors block glucose uptake and reduce tumor growth and survival in a xenograft model of pancreatic cancer. We suggest that Me4FDG-PET imaging may be used to diagnose and stage pancreatic and prostate cancers, and that SGLT2 inhibitors, currently in use for treating diabetes, may be useful for cancer therapy.
Synthesis of an RGD‐Sialyl‐Lewis<sup>X</sup> Glycoconjugate: A New Highly Active Ligand for P‐Selectin<sup>**</sup> (1995)

Complex saccharide-peptide conjugates are accessible through an efficient fragment condensation in which the partially protected RGD peptide is coupled with the sialyl LewisX amine unit to form 1. Compound 1 is the most potent antagonist for P-select-in yet reported.
Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus. (1995)

The receptor for hepatocyte growth factor/scatter factor (HGF/SF) was originally identified as an oncogene, Tpr-Met, which consists of the cytoplasmic tyrosine kinase domain of the HGF/SF receptor (Met) fused down-stream of sequences encoded by the tpr gene. As a consequence of this rearrangement the Tpr-Met fusion oncoprotein is localized to the cytoplasm and is a constitutively activated kinase. To identify signalling pathways important for Tpr-Met-mediated cell transformation we have generated tyrosine to phenylalanine mutants of Tpr-Met that are compromised in their ability to transform Fischer rat 3T3 (Fr3T3) cells in culture. We show that a single tyrosine residue in the carboxy terminus of Tpr-Met (residue 489) is essential for efficient transformation of Fr3T3 cells by this oncoprotein. Mutation of tyrosine 489 to phenylalanine does not affect the exogenous kinase activity of the Tpr-Met oncoprotein toward casein, but it impairs the ability of the mutant protein to bind to and activate phosphatidylinositol 3 kinase in vivo and completely abolishes the in vivo association with the Grb2 adaptor protein as well as the association and/or phosphorylation of an unknown protein of 110 kDa. These data are consistent with a single tyrosine residue in the Tpr-Met oncoprotein being essential for the activation of several signalling pathways which lead to the transformation of Fr3T3 fibroblasts.
Makromolekulare Chemie und Medizin (1970)

Abstract Makromolekulare Stoffe werden in der Medizin als Material und als Reagentien verwendet. Als Material dienen die Polymeren beispielsweise zum Ersatz von Weichteilen, Gefäßen und Knochen sowie als Klebstoffe. Als Reagentien treten die Makromoleküle in Wechselwirkung mit dem lebenden Gewebe und nehmen aktiv an den Reparaturprozessen teil.
Effect of combination of montelukast and levocetirizine on otitis media with effusion: a prospective, placebo-controlled trial (2013)

The amelioration of bilateral otoscopic sign scores in the combination therapy group was statistically significantly greater than in all the other groups (p < 0.05). Improvement in bilateral tympanometric findings in the combination therapy group and montelukast group was greater than in the other groups. However, this difference was not statistically significant (p > 0.05). When we compared the difference between otoscopic sign scores before and after treatment we found that it was statistically significant in every group (p > 0.05). However, the significant improvement in tympanometric findings occurred in all groups except the levocetirizine group (p > 0.05).
Neural phenotype expression of cultured human cord blood cells in vitro (2001)

Neural stem cells have been proposed as useful vectors for treating diseases in the CNS, but their utility is severely limited by lack of accessibility. Brain development is ongoing extensively in early postnatal life. However, it is unclear whether stem cells that differentiate into neurons exist in the blood during early postnatal life. We showed in this experiment that neural markers (NeuN, neurofilament, MAP2, GFAP) are expressed and long cytoplasmic processes are elaborated in the cultured human cord blood monocytes prepared from newborn umbilical blood. These results suggest that stem cells in human cord blood may be potential sources of neurons in early postnatal life. We suggest that the neonatal blood system functions as a circulating pool of different types of stem cell.
Down-Regulation of ECRG4, a Candidate Tumor Suppressor Gene, in Human Breast Cancer (2011)

Our data suggest that ECRG4 is a candidate TSG in breast cancer, the expression of which may help improve the prognostication. If functional analyses confirm this TSG role, restoring ECRG4 expression in the tumor may represent a promising therapeutic approach.
Studies on the mechanism of immunoglobulin binding to red cells. (1967)

The red cell uptake of IgG on the basis of absorption experiments appears to be due to two populations of IgG molecules. One population is readily absorbable by red cells. The quantity of this type of IgG varies from preparation to preparation and appears to depend on the method used for preparing the IgG. It appears that this population of IgG molecules represents denatured or aggregated IgG, although no direct evidence of aggregation was obtained in these studies. The other population of red cell absorbable IgG appears to be proportional to the IgG concentration and cannot be depleted by successive red cell absorption of the IgG solution. A similar pattern of reactivity with red cells was found using [(131)I] IgM. Labelled subunits of IgM and fragments of IgG (Fab and Fc), differed from IgG and IgM in that they did not contain a population consisting of a variable quantity of readily absorbable molecules.
Examination of Methods That Adjust Observed Traffic Volumes on a Network (2000)

As the models of transportation planning and engineering become more and more sophisticated, the quality of data that is used as input to the models is of critical importance to the integrity of the analysis. Several methods that adjust the field-traffic-volume data so that they become consistent and useful information for the subsequent analysis steps are examined. Consistency as satisfaction of flow conservation and other relationships underlying the network flow in question are defined. Six methods, including the manual method, are presented, and the logic and computational process are explained for each method. Except for the manual method, the methods are grouped into two general categories and discussed—one considers inconsistency in the data as a result of the statistical error and uses the classical-regression approach, and the other considers the observed value as the approximate value and uses the fuzzy-set theory. These methods are compared for their performance using an example problem. Transportation analysts’ alternative methods for volume adjustment are provided, and the analysts’ theoretical and practical implications are explained.
Increased Endothelial Monocyte Chemoattractant Protein-1 and Interleukin-8 in Preeclampsia (2002)

In Brief OBJECTIVE To test the hypothesis that preeclampsia is associated with increased endothelial cell chemokine production of monocyte chemoattractant protein-1 and interleukin-8 necessary for monocyte recruitment to the vascular endothelium. METHODS Plasma was collected from women with severe preeclampsia and normal pregnant women at term and measured for monocyte chemoattractant protein-1, interleukin-8, and lipid peroxide levels by enzyme-linked immunosorbent assays and malondialdehyde assays. Human umbilical vein endothelial cells were cultured with 5% plasma from normal or preeclamptic patients and the media assayed for monocyte chemoattractant protein-1 and interleukin-8 production. RESULTS In women with severe preeclampsia, plasma levels of monocyte chemoattractant protein-1, interleukin-8, and lipid peroxides were elevated (1.5-fold, 2.5-fold, and 4.5-fold higher, respectively) compared with normal pregnant women. Human umbilical vein endothelial cells cultured with plasma from preeclamptic women significantly increased the production of both monocyte chemoattractant protein-1 (2.3-fold) and interleukin-8 (1.5-fold) compared with plasma from normal pregnant women. Monocyte chemoattractant protein-1 and interleukin-8 production was decreased by the antioxidant vitamin E in human umbilical vein endothelial cells treated with preeclamptic plasma, suggesting that the production of these cytokines may be regulated by signaling mechanisms sensitive to oxidative stress. CONCLUSION These findings support the hypothesis that circulating factors in the plasma of women with preeclampsia activate endothelial cell monocyte chemoattractant protein-1 and interleukin-8 production, and although not directly examined in this study, may increase monocyte adherence to the vascular endothelium. Plasma from women with severe preeclampsia has increased monocyte chemoattractant protein-1 and interleukin-8 and stimulates the production of these chemokines in vascular endothelial cells.
Syntheses for 2‐hydroxy‐2<i>H</i>‐1,4‐benzothiazin‐3(4<i>H</i>)‐one derivatives as thio analogues of natural hemiacetals (1994)

Abstract Reductive cyclizations of methyl 2‐(2‐nitrophenylthio)acetate 2 by means of electrochemistry or by catalytic hydrogenation have been used as key steps in the syntheses of the hemiacetals 2‐hydroxy‐2 H ‐1,4‐benzothiazin‐3(4 H )‐one 10 and its 4‐hydroxy derivative 9 representing thio analogues of allelo chemicals found in Gramineae and Acanthaceae. In contrast to its natural counterpart 2,4‐dihydroxy‐2 H ‐1,4‐benzoxa‐zin‐3(4 H )‐one hydroxamic acid 9 did not undergo degradation by extrusion of formic acid.
Provenance Integration Requires Reconciliation (2011)

While there has been a great deal of research on provenance systems, there has been little discussion about challenges that arise when making different provenance systems interoperate. In fact, most of the literature focuses on provenance systems in isolation and does not discuss interoperability – what it means, its requirements, and how to achieve it. We designed the Provenance-Aware Storage System to be a generalpurpose substrate on top of which it would be “easy” to add other provenance-aware systems in a way that would provide “seamless integration” for the provenance captured at each level. While the system did exactly what we wanted on toy problems, when we began integrating StarFlow, a Python-based workflow/provenance system, we discovered that integration is far trickier and more subtle than anyone has suggested in the literature. This work describes our experience undertaking the integration of StarFlow and PASS, identifying several important additions to existing provenance models necessary for interoperability among provenance systems.
A critical role for the chimpanzee model in the study of hepatitis C† (2004)

Chimpanzees remain the only recognized animal model for the study of hepatitis C virus (HCV). Studies performed in chimpanzees played a critical role in the discovery of HCV and are continuing to play an essential role in defining the natural history of this important human pathogen. In the absence of a reproducible cell culture system, the infectivity titer of HCV challenge pools can be determined only in chimpanzees. Recent studies in chimpanzees have provided new insight into the nature of host immune responses-particularly the intrahepatic responses-following primary and secondary experimental HCV infections. The immunogenicity and efficacy of vaccine candidates against HCV can be tested only in chimpanzees. Finally, it would not have been possible to demonstrate the infectivity of infectious clones of HCV without chimpanzees. Chimpanzees became infected when RNA transcripts from molecular clones were inoculated directly into the liver. The infection generated by such transfection did not differ significantly from that observed in animals infected intravenously with wild-type HCV. The RNA inoculated into chimpanzees originated from a single sequence, and the animals therefore had a monoclonal HCV infection. Monoclonal infection simplifies studies of HCV, because virus interaction with the host is not confounded by the quasispecies invariably present in a natural infection. It furthermore permits true homologous challenge in studies of protective immunity and in testing the efficacy of vaccine candidates. Finally, this in vivo transfection system has made it possible to test for the first time the importance of genetic elements for HCV infectivity.
Fractionation of yeast biomass. VIII. Utilization of nucleic acids fraction. (1992)

V ramci programu frakcionacie pekarskeho droždia zameraneho na sucasnu pripravu kvasnicneho extraktu, inverlazy, ergosterolu, fosfolipidov, biosorbentov na baze bunkových stien, β-glukanu, manoproteinov po indukovanej autolýze buniek, boli v tejto praci mapovane degradacne produkty nukleových kyselin s cieľom zlepsit kvalitativne parametre produktov frakcionacie hlavne kvasnicneho extraktu. Okrem toho boli preverene niektore metody izolacie RNA s cieľom využitie ziskaných preparatov pre veterinarne, potravinarske a medicinske aplikacie.
Distributed computation for direct position determination emitter location (2014)

Classical geolocation based on time-difference-of-arrival (TDOA) and frequency-difference-of-arrival (FDOA) uses a two-stage estimation approach. The single-stage approach direct position determination (DPD) has been proposed to improve accuracy. However, unlike the classical two-stage method, the proposed DPD method does all processing at a single node. That is not desirable when computational capabilities are limited and makes the approach nonrobust to loss of the central sensor. We develop and assess several DPD variants that address these issues.
Improvement of Corynebacterium glutamicum for production of lysine and ectoine from industrial raw materials (2016)

Corynebacterium glutamicum is of huge importance in the production of amino acids and has an impressive portfolio of substrates and products.\nIn this thesis it was shown that elevated growth temperature led to decreased biomass yield and specific growth rate and to increased lysine yield. At 38°C, the lysine yield was ca. 40-55% higher than at 30°C. Metabolic flux analysis of C. glutamicum Lys12 revealed 101% flux through the pentose phosphate pathway at 38°C as compared to 86% at 30°C. In a fed-batch bioreactor setup, the cultivation at 38°C led to a 10% higher yield, as compared to 30°C.\nAlso, C. glutamicum Lys12 was modified to allow for growth and lysine production from xylose via expression of the Escherichia coli genes xylA and xylB. The resulting strain C. glutamicum Xyl1 was able to grow at 0.17 1/h and converted xylose into lysine at a yield of 0.25 mol/mol. In a more industry-like fed-batch bioreactor setup 116 g/L lysine were produced with a xylose based medium.\nFinally, the Pseudomonas stutzeri ectABCD operon (with the osmosensitive promoter exchanged for a constitutive one and the codon usage of C. glutamicum considered) was expressed in C. glutamicum lysC T311I to enable ectoine production. This strain produced ectoine (19 mmol/mol) from glucose, but also lysine, which was stopped by deletion of lysE. Elevated temperatures led to improved ectoine secretion and 4.5 g/L ectoine could be produced in a fed-batch process at 35°C.
Incremental statistical geo-temporal structuring of a personal camera phone image collection (2004)

This paper makes a proposal for automatically organizing the personal image collection that would be collected from a mobile phone equipped with a digital camera. Doing so, it attempts to address emerging needs from this rapidly developing device family. Having sketched user needs, we underline the interest of temporal and spatial meta-data in the chosen context. Collection organization is then formulated as an unsupervised classification problem, in both space and time. A criterion and an estimation procedure are proposed, based on the statistical integrated completed likelihood criterion, providing effective solutions to model complexity determination, non-Gaussianity of clusters, and incrementality. For further summarization, a technique for fusing the temporal and geolocation-based partitions is finally put forward, to ease browsing of the image collection along a single dimension.
Nonparametric discovery of human routines from sensor data (2014)

People engage in routine behaviors. Automatic routine discovery goes beyond low-level activity recognition such as sitting or standing and analyzes human behaviors at a higher level (e.g., commuting to work). With recent developments in ubiquitous sensor technologies, it becomes easier to acquire a massive amount of sensor data. One main line of research is to mine human routines from sensor data using parametric topic models such as latent Dirichlet allocation. The main shortcoming of parametric models is that it assumes a fixed, pre-specified parameter regardless of the data. Choosing an appropriate parameter usually requires an inefficient trial-and-error model selection process. Furthermore, it is even more difficult to find optimal parameter values in advance for personalized applications. In this paper, we present a novel nonparametric framework for human routine discovery that can infer high-level routines without knowing the number of latent topics beforehand. Our approach is evaluated on public datasets in two routine domains: a 34-daily-activity dataset and a transportation mode dataset. Experimental results show that our nonparametric framework can automatically learn the appropriate model parameters from sensor data without any form of model selection procedure and can outperform traditional parametric approaches for human routine discovery tasks.