gebhart/patrepeval huggingface dataset:
Relationship between the content of lysyl oxidase-dependent cross-links in skin collagen, nonenzymatic glycosylation, and long-term complications in type I diabetes mellitus. (1990)

Many abnormalities in collagen have been reported in insulin-dependent diabetes mellitus, some or all of which have been attributed to increased cross-linking. Although recent work has focused on the role of glucose-derived collagen cross-links in the pathogenesis of diabetic complications, relatively few studies have investigated the role of lysyl oxidase-dependent (LOX) cross-links. In the present study, LOX cross-links and nonenzymatic glycosylation were quantified in skin collagen from diabetic subjects. There was an increase in the difunctional cross-link dihydroxylysinonorleucine (DHLNL) as well as in one of its trifunctional maturation products, hydroxypyridinium. All other LOX crosslinks were normal. Nonenzymatic glycosylation was increased in diabetic skin collagen, and this increase was correlated with increases in DHLNL (P less than 0.001). The biochemical results were examined for correlations with clinical data from the same subjects. Increases in DHLNL content were associated with duration of diabetes (P less than 0.003), glycohemoglobin levels (P less than 0.001), hand contractures (P less than 0.05), skin changes (P less than 0.005), and microalbuminuria (P less than 0.01). In nondiabetic subjects age was not correlated with collagen cross-link content with the exception that his-HLNL increased with age (r = 0.79, P less than 0.02). In diabetic subjects, PA levels decreased with age (r = 0.51, P less than 0.02). With increased duration of diabetes, DHLNL content was increased (r = 0.55, P less than 0.003) and OHP was increased (r = 0.59, P less than 0.01), whereas PA levels were decreased (r = -0.48, P less than 0.04). Nonenzymatic glycosylation of collagen was also increased with increased duration of diabetes (hex-lys, r = 0.47, P less than 0.02; hex-hyl, r = 0.39, P less than 0.05). We conclude that: (a) lysyl oxidase-dependent cross-linking is increased in skin collagen in diabetes and (b) that these changes in skin collagen are correlated with duration of diabetes, glycemic control, and long-term complications.
Higher order error of discrete fiber model and asymptotic bound on multistaged PMD compensation (2000)

We develop a random-matrix formalism that enables analysis of a variety of polarization-mode dispersion (PMD) related problems. In particular, we address the problems of higher order error in a discrete fiber model and limit of multistaged PMD compensation schemes. Our solution to the first problem leads to a simple condition for the validity of the model, which is often overlooked in PMD simulations. For the second issue, we have found an asymptotic bound on the limit of a multistaged PMD compensation scheme. The theory is confirmed by numerical simulations, and future work is suggested.
Natural Antibodies against Phosphorylcholine in Cardiovascular Disease (2009)

Atherosclerosis is a chronic inflammatory disease characterized by the presence of activated immune-competent cells in the lesions, producing mainly proinflammatory cytokines. Atherosclerosis is the underlying cause of cardiovascular disease (CVD), to a large extent occurring after damage and/or rupture of the atherosclerotic plaques. One major factor implicated as a cause of this immune activation is modified low-density lipoproteins (LDL), especially oxidized forms (oxLDL), which are abundant in plaques, both in foam cells and in the necrotic core. The LDL-oxidation process is very complex, and the nature of the antigens has been difficult to identify. We and others have focused on the phospholipids (PL) in oxLDL, especially oxidized forms of PL, including platelet-activating factor (PAF)-like lipids and lysophosphatidylcholine (LPC), and demonstrated that these could play a major role through proinflammatory effects. One common epitope is phosphorylcholine (PC), which is also exposed on some microorganisms (including Streptococcus pneumoneae) and on apoptotic cells. Natural IgM antibodies against PC (anti-PC) have been known for a long time, but little has been reported about their role in human disease, especially in CVD. We have demonstrated that anti-PC IgM are negatively associated with atherosclerosis development in hypertensive individuals and that low levels of anti-PC independently predict development of CVD. Anti-PC IgM could, therefore, be a novel risk marker in CVD. Animal experiments indicate that both active immunization with PC and passive immunization with anti-PC ameliorate atherosclerosis development. The possibility that anti-PC could be used therapeutically in humans deserves further study.
The Shift of Th1 to Th2 Immunodominance Associated with the Chronicity of <i>Mycobacterium bovis</i> Bacille Calmette-Guerin Infection Does Not Affect the Memory Response (2003)

In the present study we investigated the shaping and evolution of the immunodominance of the T cell response during a chronic mycobacterial infection. Using a recombinant bacille Calmette-Guérin expressing a reporter Ag, the Escherichia coli MalE protein, we analyzed the peptide specificity and the cytokine profile of the T cell response to the reporter Ag by ELISPOT. During the early steps of infection, the T cell response was focused on two dominant MalE epitopes and was characterized by a pure IFN-gamma response. Then, in the course of infection the initial IFN-gamma response to these two epitopes shifted to a mixed IFN-gamma/IL-4 response. At the same time, the peptide specificity of the T cell response was broadened to two additional MalE epitopes characterized by a unique IL-4 response resulting in the establishment of a dominant IL-4 response to the MalE protein at 16 wk postinfection. However, this phenomenon did not impair the outcome of a predominant IFN-gamma response upon subsequent MalE recall in vivo performed in the presence of CFA, a Th1-driving adjuvant. These results indicate that the Th2 nature of the immune response established during a chronic infection, which most likely reflects regulatory mechanisms to allow the return to T cell homeostasis, does not shape the Th1/Th2 nature of the memory response.
LytG of <i>Bacillus subtilis</i> Is a Novel Peptidoglycan Hydrolase:  The Major Active Glucosaminidase (2002)

LytG (YubE) of Bacillus subtilis is a novel 32 kDa autolysin produced during vegetative growth under the control of Esigma(A) RNA polymerase. Muropeptide analysis of vegetative cells of B. subtilis revealed LytG to be the major glucosaminidase responsible for peptidoglycan structural determination during vegetative growth. Overexpression and purification of LytG allowed its biochemical characterization. Despite sequence homology suggesting muramidase activity, LytG is a novel glucosaminidase with exoenzyme activity and may form part of a novel family of autolysins. It is involved in cell division, lysis, and motility on swarm plates.
Simultaneous acquisition of image and navigator slices using CAIPIRINHA for 4D MRI (2014)

We present a novel imaging method for truly simultaneous acquisition of image and navigator slices for four-dimensional (4D) MRI of organ motion. In this method, the time lag between the sequential acquisitions is eliminated, leading to an improved accuracy of organ motion models, while CAIPIRINHA reconstruction results in an improved SNR compared with an existing 4D MRI approach.
Direct modulation of long-cavity semiconductor lasers (1996)

The application of a high-speed signal via the drive current to a long-cavity semiconductor laser (cavity length >/spl sim/1 cm) differs from the short-cavity case in that the variation of the optical field within one round-trip time is not negligible. We theoretically investigate the modulation response for a semiconductor laser of arbitrary length and relate it to experiments on the multifrequency waveguide grating router laser, a long-cavity laser. We find that the largest modulation bandwidth is achieved by having the modulated amplifier and the desired output as far apart as possible, the modulation bandwidth can be further increased by simple electronic precompensation, and because of fast nonlinearities the broadband intensity modulation of long-cavity lasers exhibits substantially less chirp than short-cavity lasers, the chirp essentially equal to that of the amplifiers. Finally, we demonstrate the direct modulation of three channels simultaneously in a multifrequency laser at 1.24 Gb/s each.
« Gengis Khan » d’Henry Bauchau: anatomie de la première mise en scène d’Ariane Mnouchkine en 1961 (2020)

“Gengis Khan” by Henry Bauchau: Anatomy of Ariane Mnouchkine’s First Stage Direction in 1961 “Genghis Khan” by Henry Bauchau holds an important place in the theater of the second half of the XXth century by becoming the first staging of Ariane Mnouchkine. Yet we replace the physical body with a "materia theatrali, digna spectaculo” where Genghis Khan will expose himself to the gaze of the anatomist. Just as each organ has a function, we will strive to isolate the elements to circumscribe the major galvanic functions and to separate the genesis and history. Genghis Khan extends into complex branch-es from psychoanalysis to the clash of civilizations, from great history to personal destinies, the game of tracks between digressions of archaeology, anthropology, historiography, and we will place him in his dramatic reality, the sum of which is greater than its parts: "Is it Genghis Khan who enlarged the world ... Or is the world who enlarged Genghis Khan?" (Bauchau,1959,96).
On designing a cost-aware virtual CDN for the federated cloud (2016)

We have developed a prototype for a cost-aware, cloud-based content delivery network (CDN) suitable for a federated cloud scenario. The virtual CDN controller spawns and releases virtual caching proxies according to variations in user demand. A cost-based heuristic algorithm is used for selecting data centers where proxies are spawned. The functionality and performance of our virtual CDN prototype were evaluated in the XIFI federated OpenStack cloud. Initial results indicate that the virtual CDN can offer reliable and prompt service. Multimedia providers can use this virtual CDN solution to regulate expenses and have greater freedom in choosing the placement of virtual proxies as well as more flexibility in configuring the hardware resources available to the proxy (e. g., CPU cores, memory and storage).
환경이 참굴에 미치는 영향 (2002)

In this study, the oyster, Crassostrea Gigas which is composed of alternating nanoscale layers of calcium carbonate plate and organic matrix and is widely cultivated in Korea, is mainly focused to get a better understanding of the effect of environmental conditions on the formation of shell. It is suggested that environmental conditions are main factor for the transition normal shell into deformed shell through EA, EDS and crystal growth.
Lovastatin therapy in heterozygous familial hypercholesterolaemic patients: effect on blood rheology and fibrinogen levels (1991)

Thirteen heterozygous familial hypercholesterolaemic patients were treated with lovastatin for 1 year, and were investigated for the effect on lipid profile, blood rheology and fibrinogen levels. A significant dose-dependent reduction in serum levels of total and LDL-cholesterol, Apo B and the ratio of total cholesterol to HDL-cholesterol was noted. Improvement in red blood cell filterability and an increase in fibrinogen levels were also observed. We conclude that the hypocholesterolaemic effect of lovastatin in familial hypercholesterolaemia is accompanied by changes in blood rheology. While some of these haemorheological changes may be considered beneficial, others may be regarded as unfavourable. The net effect of lovastatin therapy on the coronary risk of familial hypercholesterolaemic patients warrants further investigation.
Variational Surface Approximation and Model Selection (2009)

Abstract We consider the problem of approximating an arbitrary generic surface with a given set of simple surface primitives. In contrast to previous approaches based on variational surface approximation, which are primarily concerned with finding an optimal partitioning of the input geometry, we propose to integrate a model selection step into the algorithm in order to also optimize the type of primitive for each proxy. Our method is a joint global optimization of both the partitioning of the input surface as well as the types and number of used shape proxies. Thus, our method performs an automatic trade‐off between representation complexity and approximation error without relying on a user supplied predetermined number of shape proxies. This way concise surface representations are found that better exploit the full approximative power of the employed primitive types.
Asynchronous circuits and systems in superconducting RSFQ digital technology (2002)

Superconductive Rapid Single Flux Quantum (RSFQ) logic and memory, in which ones and zeros are represented by the presence or absence within a timing window of quantized picosecond voltage pulse (/spl int/v(t)dt=h/2e=2.07 mV/spl middot/ps), corresponding to one SFQ, can be integrated into a digital computing system with an operating rate of several tens of GHz, based on the present Nb Josephson junction integrated circuit technology. It is the most promising technology beyond semiconductor transistors for low-power high-end computation. However, as the operating speed of circuits and systems increase, timing uncertainty from fabrication process variations makes global synchronization very hard. In this paper, we present a globally asynchronous, locally synchronous timing methodology for RSFQ digital design, which can solve the global synchronization problem. We also demonstrate the recent experimental results of some asynchronous circuits and systems implemented in RSFQ technology. Several key components such as a self-timed shift register, a self-timed demultiplexor, a Muller-C element, a completion detector, and a clock generator have been designed and tested. High speed operation has been confirmed up to 20 Gb/s for a prototype data buffer system, which consists two self-timed shift registers and an on-chip 5-38 GHz clock generator.
Induction of Alzheimer Antigens by an Uncoupler of Oxidative Phosphorylation (1990)

Since previous studies have suggested that the coupling of oxidation to phosphorylation is impaired in Alzheimer brain and fibroblasts, the effects of carbonyl cyanide m-chlorophenylhydrazone, a hydrazone known to uncouple mitochondrial oxidative phosphorylation, were tested on the development of immunoreactivity with antibodies to "Alzheimer antigens" in cultured fibroblasts from cognitively intact subjects. The fibroblasts were exposed for 10 to 14 days to a medium (DMd) modeled on media that favor neuronal differentiation in fetal brain cultures. The addition of a 10-microns concentration of carbonyl cyanide m-chlorophenylhydrazone to the DMd culture medium increased by more than 10-fold the proportion of cells reacting immunocytochemically with antibodies to paired helical filaments and by 157-fold the proportion of cells reacting with the Alz-50 monoclonal antibody. These observations suggest that the oxidative abnormalities previously described in tissues from patients with Alzheimer's disease may contribute to the accumulation of abnormal cytoskeletal materials in this disorder.
Role of Melanopsin in Circadian Responses to Light (2002)

Melanopsin has been proposed as an important photoreceptive molecule for the mammalian circadian system. Its importance in this role was tested in melanopsin knockout mice. These mice entrained to a light/dark cycle, phase-shifted after a light pulse, and increased circadian period when light intensity increased. Induction of the immediate-early gene c-fos was observed after a nighttime light pulse in both wild-type and knockout mice. However, the magnitude of these behavioral responses in knockout mice was 40% lower than in wild-type mice. Although melanopsin is not essential for the circadian clock to receive photic input, it contributes significantly to the magnitude of photic responses.
Anthropometric Procedures for Protective Equipment Sizing and Design (2012)

The study provided a basis for equipment designers, standards writers, and industry manufacturers to advance anthropometric applications for product design and improve product efficacy.
Brief for the Appellant, State of Rocky Mountain: Thirteenth Annual Pace National Environmental Moot Court Competition (2001)

2. The overburden in Lustra Creek remains a remediable problem and thus a continuing violation under the Gwaltney I standard... a.The overburden in
Tumour-promoting and hyperplastic effects of phorbol and daphnane esters in CD-1 mouse skin and a synergistic effect of calcium ionophore with the non-promoting activator of protein kinase C, sapintoxin A (1989)

Using an 18 week two-stage protocol we have compared the tumour-promoting properties of a range of phorbol and daphnane esters on female CD-1 mice. The induction of epidermal hyperplasia in this mouse strain by these compounds has also been assessed by comparison with the standard phorbol ester, 12-O-tetradecanoylphorbol-13-O-acetate (TPA). Two compounds, sapintoxin D (SAP D) and thymeleatoxin A (TA) (a daphnane structurally related to the second-stage promoter mezerein) were shown to be second-stage promoters using 5 nmol TPA as a first-stage promoter and 0.2 mumol 7,12-dimethylbenz[a]anthracene (DMBA) as initiator. Both compounds at a dose of 17 nmol were hyperplasiogenic. Two further derivatives, sapintoxin C (SAP C) and 4 alpha-sapinine (alpha-SAP) were inactive as promoters and hyperplastic agents. 4 alpha-sapinine, which prevents in vitro stimulation of protein kinase C (PKC), by 12-O-tetradecanoylphorbol-13-O-acetate (TPA) failed to inhibit significantly TPA-induced promotion and hyperplasia at a dose of 20 nmol and 100 nmol respectively. Sapintoxin A (SAP A), a potent activator of PKC, was neither a complete nor second-stage promoter at doses of up to 20 nmol. A series of in vivo and in vitro experiments which were carried out to determine the metabolic fate of this compound under experimental conditions showed that SAP A was not metabolized to any significant extent up to 48 h. When SAP A was co-administered with sub-hyperplastic doses of the calcium ionophore A23187 (5 micrograms and 10 micrograms) tumours appeared in a dose-dependent manner. This combination was also hyperplasiogenic in mouse skin. SAP A may be a useful probe for studying the involvement of PKC isozymes in tumour promotion and cell proliferation.
ChemInform Abstract: STEREOSPECIFIC SYNTHESIS OF DL‐TRIACETYLDAUNOSAMINE (1976)

Abstract Die selektive Bromierung des Oxarzols (Ia) mit N‐Bromsuccinimid zum Brommethylderivat (Ib), dessen Umsetzung mit KCN in HCN‐Äther im Bombenrohr zum Cyanid (Ic) und dessen Reaktion mit HCl‐Methanol liefert den Ester (Id), der mit HCl‐Essigsäure zur Carbonsäure (Ie) hydrolysiert wird.
Pseudo-digital quantum bits (2002)

Quantum computers are analog devices; thus they are highly susceptible to accumulative errors arising from classical control electronics. Fast operation—as necessitated by decoherence—makes gating errors very likely. In most current designs for scalable quantum computers, it is not possible to satisfy both the requirements of low decoherence errors and low gating errors. Here, we introduce a hardware-based technique for pseudo-digital gate operation. We perform self-consistent simulations of semiconductor quantum dots, finding that pseudo-digital techniques reduce operational error rates by more than two orders of magnitude, thus facilitating fast operation.
Electrical characteristics of ultrathin gate oxide prepared by postoxidation annealing in ND3 (2000)

The electrical and reliability characteristics of ultrathin gate oxide, annealed in ND3 gas, have been investigated. Compared with a control oxide, which had been annealed in NH3, the ND3-nitrided oxide exhibits a significant reduction in charge trapping and interface-state generation. The improvement of electrical and reliability characteristics can be explained by the strong Si–D bond at the Si/SiO2 interface. This nitridation process of a gate dielectric using ND3 has considerable potential for future ultra-large-scale integration device applications.
Coils producing a magnetic field gradient for diffusion measurements with NMR (1976)

Sets of coils providing linear gradients of any desired direction are described. The coils are small and placed in the NMR probe head. Power consumption is low and the rise time of the pulsed gradient is extremely short (a few microseconds).
Über Wirkung und Erbgang gelbverstärkender Faktoren (y-Faktoren) bei wild- und lohfarbigen Hauskaninchen (1972)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Significance of location of enzymes on their release during microbial cell disruption (2001)

The release kinetics of the enzyme invertase and alcohol dehydrogenase from yeast and penicillin acylase from E. coli during disruption using various techniques has been investigated. The disruption techniques used were sonication, high-pressure homogenization, and hydrodynamic cavitation. The first-order-release kinetics was applied for the determination of release rate of these enzymes and total soluble proteins. Location factor (LF) values were calculated using these release rates. The location of the enzymes as given by the values of location factor coincided well with those reported in the literature. Varying values of location factor for the same enzyme by different disruption techniques gave some indications about the selectivity of release of a target enzyme by different disruption techniques. Varying values of location factor for the same enzyme with the use of a particular equipment or disruption technique at different conditions reveals the degree to which the cell is disrupted. Few plausible applications of this location factor concept have been predicted and these speculations have been examined. This location factor concept has been used for monitoring the heat-induced translocation of ADH and location of penicillin acylase during the growth period of E. coli cells.
Initial Clinical Results of Tenecteplase (TNK) in Catheter-Directed Thrombolytic Therapy (2002)

Purpose: To investigate the safety and immediate efficacy of 2 different doses of tenecteplase (TNK) in peripheral catheter-directed thrombolytic therapy of arterial occlusions and deep vein thrombosis (DVT). Methods: Over a 20-month period, 63 nonconsecutive patients underwent catheter-directed thrombolytic therapy with either 0.25 mg/h or 0.50 mg/h of TNK in a nonrandomized, open-label study. Of these, 55 patients (60 limbs) were treated for DVT (36 limbs in 16 men and 15 women; mean age 41 years, range 21–73) or peripheral arterial occlusions (24 limbs in 16 men and 8 women; mean age 63 years, range 32–91). The primary endpoints were major bleeding complications and angiographic reduction in clot burden. Results: The mean duration of infusion was 18 ± 4 hours in patients with arterial occlusions and 30 ± 13 in those with DVT. Twenty-one (87.5%) patients with occlusive disease had marked or complete lysis of clot. Thirty (83.3%) limbs with DVT had either marked or complete resolution of thrombus. There were 4 (7.3%) episodes of minor bleeding with 1 (1.8%) major hemorrhagic event. Fibrinogen levels dropped by an average of 23%. Conclusions: Preliminary evidence suggests that TNK doses of 0.25 mg/h to 0.50 mg/h appear to be safe and effective. The potential benefits of TNK therapy warrant further investigation.