gebhart/patrepeval huggingface dataset:
Two Timing Samplers (1981)

Testing VLSl chips presents a variety of problems. some of which can be solved by building on-chip testing\nstructures. On-chip testing structures can allow a designer to test aspects of a circuit which might be difficult to\ntest even with expensive test equipment and moreover can provide reasonable testing hardware to designers who\ndo not have access to sophisticated off-chip testing equipment.\n\nIn this paper we describe a type of on-chip test structure called H timing sampler which enables the designer to\naccurately measure when on-chip signal transitions occur. The timing samplers we present are simple. They\nhave been fabricated as part of a multi-project chip and experimental results show that they arc reasonably\naccurate as well.
Recognition Imaging and Highly Ordered Molecular Templating of Bacterial S-Layer Nanoarrays Containing Affinity-Tags (2008)

Functional nanoarrays were fabricated using the chimeric bacterial cell surface layer (S-layer) protein rSbpA fused with the affinity tag Strep-tagII and characterized using various atomic force microscopy (AFM) techniques in aqueous environment. The accessibility of Strep-tagII was verified by single-molecule force spectroscopy studies employing Strep-Tactin as specific ligand. Simultaneous topography and recognition imaging (TREC) of the nanoarray yielded high resolution maps of the Strep-tagll binding sites with a positional accuracy of 1.5 nm. The nanoarrays were used as template for constructing highly ordered molecular binding blocks.
Alkoxyaminosilanes (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkoxyaminosilanesC. Miner, Jr., L. Bryan, R. Holysz, Jr., and G. Pedlow, Jr.Cite this: Ind. Eng. Chem. 1947, 39, 11, 1368–1371Publication Date (Print):November 1, 1947Publication History Published online2 February 2005Published inissue 1 November 1947https://doi.org/10.1021/ie50455a600Request reuse permissions Article Views197Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (591 KB) Get e-Alerts
The role of ClC‐3 in volume‐activated chloride currents and volume regulation in bovine epithelial cells demonstrated by antisense inhibition (2000)

1. A chloride current with mild outward rectification was induced in the native bovine non-pigmented ciliary epithelial (NPCE) cells by a 23 % hypotonic solution. The current showed no or little inactivation at depolarized steps. 2. ATP blocked 88 and 61 % of the outward and inward components of the volume-activated chloride current (ICl,vol) with an IC50 of 5.3 and 9.6 mM, respectively. 3. The volume-activated chloride current was decreased and the activation of the current was delayed by inhibiting endogenous ClC-3 expression using a ClC-3 antisense oligonucleotide. The inhibition of the current as a function of antisense concentration was asymptotic with a maximum about 60 %. The remaining current was probably not derived from ClC-3 and was inhibited by ATP. 4. ClC-3 expression in the bovine NPCE cells was verified by immunofluorescence studies. ClC-3 immunofluorescence was distributed throughout the cells but with the predominant location within the nucleus. The expression of ClC-3 protein was diminished by the ClC-3 antisense oligonucleotide with the greatest diminution occurring in the nuclear region. 5. The size of the volume-activated chloride current was positively correlated with the ClC-3 immunofluorescence level. 6. Regulatory volume decrease of the NPCE cells was reduced by ClC-3 antisense oligonucleotide. 7. We conclude that endogenous ClC-3 is associated with the volume-activated chloride current and is involved in cell volume regulation, but that it can only contribute towards a proportion of the current in NPCE cells. 8. The nuclear predominance of ClC-3 immunofluorescence in NPCE cells, the absence of basal activity of chloride current and the marked pharmacological differences between IClC-3 and ICl,vol argue against ClC-3 being the only, or even the main, volume-activated chloride channel in NPCE cells.
A System for Dispensing Sub-Milligram Doses of Active Pharmaceutical Powders for Early Stage Solubility Assays (2004)

At early stages of drug development, the solubility of compounds is an important screening criterion. However, because scientists lack the automated tools needed to perform comprehensive early stage solubility studies, they are only able to perform a small number of experiments by hand, thus exploring only a fraction of the potential formulation design space. To allow a larger formulation design space to be explored at relatively early stages of pharmaceutical development (when 100 mg of a prototype compound is available), TransForm has created the AquaSFinX™ and SFinX™ micro-solubility platforms. In this article, a novel solid deposition system is described which is an enabling component of TransForm's solubility platforms. Given 100 mg of a starting material, the deposition system can dispense over six hundred 50-μg plugs of powder into 384-well or 1,536-well plates with well openings as small as 1.5 mm. Currently no commercial powder deposition system can provide this functionality. Including the time required to characterize and run the system, the dispense times range from around 2 minutes per dose for small runs involving 100 mg of starting material, to 18 seconds per dose for larger runs involving a gram or more of starting material.
Investigation of Amplifying and Switching Characteristics in Double Heterostructure-Emitter Bipolar Transistors (2007)

Double heterostructure-emitter bipolar transistors (DHEBTs) with emitter edge-thinning design and DHEBTs without that design have been investigated. In the characteristics modeling, a two-dimensional continuity equation and boundary conditions in the base region are employed to determine the various components of base current in a cylindrical mesa-type DHEBT. The influence of structure parameters and emitter edge-thinning design on the current gain of the DHEBT is studied. The effect of quasi-electric field in the base region is taken into account. Switching mechanisms in the DHEBT are also discussed. In the experimental measurement, a DHEBT with an exposed base surface exhibits a small offset voltage of and a common-emitter current gain of 17. Due to the emitter edge-thinning to suppress the surface recombination current, a DHEBT with an passivated surface has a common-emitter current gain of 140 and a negligible offset voltage of . With symmetric structures, both devices present bidirectional switching phenomena. Moreover, the emitter edge-thinning design is found having the capability for reducing the holding power in the switching. Possessing both amplifying and switching features, the DHEBTs show good potentials for circuit applications.
Commodity trading with a two year old (2002)

Summary form only given. Continuing work to train an artificial neural network (ANN) to recognize a long/short (buy/sell) pattern for the live cattle commodity futures market was discussed. The back-propagation of errors algorithm was used to encode the relationship between the long/sell desired output and fundamental indicators plus technical variables into the ANN. Trained on two years of past data, the ANN was able to predict long/short market positions for 5 months in the future that would have made $2752 profit on an investment of $800.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A new genus of Miltogrammatinae from Namibia (Diptera: Sarcophagidae) (1991)

Khowaba gen. n., type-species Khowaba atrox sp. n., is descriptionbed from Namibia, and its phylogenetic relationships are discussed.
A high-speed bipolar technology featuring self-aligned single-poly base and submicrometer emitter contacts (1990)

An experimental bipolar transistor structure with self-aligned base-emitter contacts formed using one polysilicon layer is presented with geometries and frequency performance comparable to those of double-polysilicon structures. This structure, called STRIPE (self-aligned trench-isolated polysilicon electrodes), provides a 0.2- mu m emitter-base polysilicon contact separation. A 0.4- mu m emitter width is achieved with conventional 0.8- mu m optical lithography. Scaling of the emitter width of 0.3 mu m has been performed with minimal degradation of device performance, and scaling of the emitter width pattern to 0.2 mu m has been demonstrated. These dimensions are the smallest achieved in single-polysilicon structures with polysilicon base contacts and are comparable to those achieved in double-polysilicon structures. The STRIPE structure has been used to fabricate transistors with f/sub t/ as high as 33.8 GHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Insertion into the<i>Mycobacterium smegmatis</i>genome of the<i>aph</i>gene through lysogenization with the temperate mycobacteriophage Ms6 (1992)

A derivative of the temperate mycobacteriophage Ms6 containing the aph gene from transposon Tn 5 was constructed. In the transductants the aph gene was integrated in the bacterial genome. The aph gene is stably maintained in the absence of positive selection after more than 150 generations. The results presented in this report show that Ms6 can be used as a vehicle for the integration of foreign DNA into the Mycobacterium smegmatis genome. a
Preparation and Properties of Polypropylene/Expended Vermiculite Micro-Nano Composite (2012)

Thermoplastics were prepared by melt blending using polypropylene [PP] and expended vermiculite ball-milled with VAE emulsion. The effect of vermiculite content and vermiculite particle diameter on the crystallization and mechanical property of PP were studied. The mechanical property of PP and the composites studied by using universal testing machine show that both mass fraction of vermiculite and particle size have consequences for mechanical property of PP, and when mass fraction of vermiculite and ball-mill 5 hours can acquire good mechanical properties. The two parameters are in agreement with morphology of the composites observing from the Scanning Electron Microscopy and polarized-light microscope. The results obtained from nonisothermal crystallization of PP and the composites, which were carried out using the differential scanning calorimetry technique, show that vermiculite with micro diameter block crystallization, while vermiculite with micro-nano diameter can induce crystallization and increase crystallization.
Statistical Models for Empirical Search-Based Performance Tuning (2004)

Achieving peak performance from the computational kernels that dominate application performance often requires extensive machine-dependent tuning by hand. Automatic tuning systems have emerged in response, and they typically operate by (1) generating a large number of possible, reasonable implementations of a kernel, and (2) selecting the fastest implementation by a combination of heuristic modeling, heuristic pruning, and empirical search (i.e. actually running the code). This paper presents quantitative data that motivate the development of such a search-based system, using dense matrix multiply as a case study. The statistical distributions of performance within spaces of reasonable implementations, when observed on a variety of hardware platforms, lead us to pose and address two general problems which arise during the search process. First, we develop a heuristic for stopping an exhaustive compiletime search early if a near-optimal implementation is found. Secondly, we show how to construct run-time decision rules, based on run-time inputs, for selecting from among a subset of the best implementations when the space of inputs can be described by continuously varying features. We address both problems by using statistical modeling techniques that exploit the large amount of performance data collected during the search. We demonstrate these methods on actual performance data collected by the PHiPAC tuning system for dense matrix multiply. We close with a survey of recent projects that use or otherwise advocate an empirical search-based approach to code generation and algorithm selection, whether at the level of computational kernels, compiler and run-time systems, or problem-solving environments. Collectively, these efforts suggest a number of possible software architectures for constructing platform-adapted libraries and applications.
Abstract 5470: Potent MEK inhibitor CIP-137401: Preclinical studies (2011)

Abstract In recent years there is a lot of interest in both pre-clinical and clinical setting for the development of MEK kinase inhibitors as therapeutic agents for various cancers. A quite few number of MEK kianse inhibitors are currently undergoing phase I/II clinical trials both as a single agent as well as a combination with variety of other anti-tumor agents. These single agents include AZD-6244, RDEA-119, GSK-1120212, AS-703026 etc. One of the factors favoring MEK kinase as a sought after target besides being a part of very relevant Ras-Raf-MEK-ERK pathway is the identification of an allosteric binding site, which provides excellent selectivity for MEK kinase inhibitors as a class. Constitutive activation of Ras-Raf-MEK-ERK pathway has been a hallmark in several cancer types, including pancreatic, colon, lung, and melanoma. MEK is selective in phosphorylating serine/threonine residues of proteins resulting in regulation of variety of physiological functions of the cell including apoptosis, differentiation, proliferation and gene expression. We recently discovered a novel, potent, non-ATP competitive, allosteric class of MEK kinase inhibitors. Our lead compound, CIP-1374, in the preliminary in vitro data that include primary enzyme assay, inhibition of ERK phophorylation, and anti-proliferation assays in various cell lines exhibited very potent activity. CIP-1374 also displayed excellent pharmaco-kinetic profile in mice with about 17h of half life with about 30% oral bioavailability. Another molecule in this series, CIP-137401 is also displaying a potent in vitro activity in various assays. We are currently focusing on CIP-137401 as our lead candidate and conducting preclinical studies. In this poster, our results in preclinical studies including rat pharmaco-kinetic, metabolic stability, and in-vitro toxicology data will be presented. The in vitro toxicology assays include its profiling in cardiac toxicity data (hERG channel activation). In addition the efficacy data from in vivo tumor xenograft models will be presented. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5470. doi:10.1158/1538-7445.AM2011-5470
Hepatectomy for hepatocellular carcinoma: Patient selection and postoperative outcome (2004)

Hepatic resection and liver transplantation are considered the only curative treatments for hepatocellular carcinoma (HCC). Liver transplantation for HCCs < or =5 cm in diameter has been shown to produce favorable survival results, but its application is limited by the lack of donors. Hepatic resection remains the treatment of choice for patients who are not transplantation candidates because of large tumor, macroscopic vascular invasion, or advanced age. For small HCCs associated with Child's A cirrhosis, hepatic resection should still be considered the first-line treatment, but salvage transplantation for intrahepatic recurrence may be a feasible strategy. Recent improvement in surgical techniques and perioperative care has increased the safety and expanded the indication of hepatic resection for HCC to include large tumors that require extended hepatectomy in cirrhotic patients. Selection of appropriate candidates for hepatectomy depends on careful assessment of the tumor status and liver function reserve. Evaluation of the general fitness of patients is also critical because comorbid illness is an important cause of postoperative mortality, even if the patients have good liver function reserve. With careful patient selection and surgical expertise, the current operative mortality of hepatectomy for HCC is about 5% or less in major centers. Improved long-term survival results after resection of HCC have also been reported recently, with an overall 5-year survival rate of about 50%. The improved perioperative and long-term survival results have strengthened the role of hepatectomy as the mainstay of treatment for HCC despite the availability of a number of other treatment options for localized HCC.
Nearly 4-Inch-Diameter Free-Standing GaN Wafer Fabricated by Hydride Vapor Phase Epitaxy with Pit-Inducing Buffer Layer (2013)

A free-standing GaN wafer was fabricated by depositing a GaN buffer that induced the formation of pits (hereafter, pit-inducing GaN buffer) on a low-temperature-grown GaN buffer on the sapphire substrate. A high-temperature-grown GaN layer was grown on the pit-inducing GaN buffer that induced the formation of pits on the high-temperature-grown GaN layer. The pit-inducing buffer suppresses crack formation in the thick GaN film thereby releasing growth stress. Thermal stress in GaN on a sapphire system is also discussed on the basis of calculations utilizing a bilayer model. We have succeeded in the fabrication of a nearly 4-in.-diameter free-standing GaN thick wafer with a pit-inducing GaN buffer by one-stop hydride vapor phase epitaxy, which will lead to a low-cost fabrication of free-standing GaN wafers.
The System Magnesium Sulfate—Urea—Water at 30° (1936)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe System Magnesium Sulfate—Urea—Water at 30°Colin W. Whittaker, Frank O. Lundstrom, and James H. ShimpCite this: J. Am. Chem. Soc. 1936, 58, 10, 1975–1977Publication Date (Print):October 1, 1936Publication History Published online1 May 2002Published inissue 1 October 1936https://pubs.acs.org/doi/10.1021/ja01301a042https://doi.org/10.1021/ja01301a042research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Electrostatic Color Map Printer (1960)

A feasibility model of an electrostatic color map printer using Electrofax paper has been constructed and demonstrated under a contract with the U.S. Army Engineering Research and Development Laboratories, Fort Belvoir, Va. This machine is designed to print five-color, <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$22{1\over2}$</tex> by 29-in. maps by optical exposure from 70mm cartographic separations. The feasibility equipment uses liquid color Electrofax development with electronic flash exposure triggered photoelectrically from the paper. The machine is web fed, the paper transport being accomplished by means of air bearings. The Electrofax approach to tactical map reproduction greatly reduces the requirement for storage of large quantities of printed maps. It reduces the logistics problems to supply of raw material. The make-ready time is a few minutes.
A new load resonant dual-output converter (2003)

The resonant dual-output converter (RDOC) is derived from the series-parallel resonant LLC converter by introducing half-wave instead of full-wave rectification. The RDOC regulates two outputs independently using a single power stage. The load range covers any combination including no-load while still maintaining zero voltage switching. This holds for an input voltage range comparable to the conventional LLC converter. The RDOC can further be operated at different secondary voltages per turn in order to meet specific low voltage load requirements. A control structure is outlined that transfers the original error signals into two actuating signals which then separately control frequency and duty cycle.
Isomers and aza‐analogues of indoxyl containing nitrogen at a ring‐fusion position: Coupling reactions with electrophiles and attempted oxidations (1986)

Abstract Derivatives of four series of compounds derived from isomers of indoxyl with the nitrogen at the bridgehead and two further series of aza‐analogues are prepared and their absorption properties studied.
In vivo recombination of Saccharomyces eubayanus maltose-transporter genes yields a chimeric transporter that enables maltotriose fermentation (2019)

Saccharomyces eubayanus is the non-S. cerevisiae parent of the lager-brewing hybrid S. pastorianus. In contrast to most S. cerevisiae and Frohberg-type S. pastorianus strains, S. eubayanus cannot utilize the α-tri-glucoside maltotriose, a major carbohydrate in brewer's wort. In Saccharomyces yeasts, utilization of maltotriose is encoded by the subtelomeric MAL gene family, and requires transporters for maltotriose uptake. While S. eubayanus strain CBS 12357T harbors four SeMALT genes which enable uptake of the α-di-glucoside maltose, it lacks maltotriose transporter genes. In S. cerevisiae, sequence identity indicates that maltotriose and maltose transporters likely evolved from a shared ancestral gene. To study the evolvability of maltotriose utilization in S. eubayanus CBS 12357T, maltotriose-assimilating mutants obtained after UV mutagenesis were subjected to laboratory evolution in carbon-limited chemostat cultures on maltotriose-enriched wort. An evolved strain showed improved maltose and maltotriose fermentation in 7 L fermenter experiments on industrial wort. Whole-genome sequencing revealed a novel mosaic SeMALT413 gene, resulting from repeated gene introgressions by non-reciprocal translocation of at least three SeMALT genes. The predicted tertiary structure of SeMalT413 was comparable to the original SeMalT transporters, but overexpression of SeMALT413 sufficed to enable growth on maltotriose, indicating gene neofunctionalization had occurred. The mosaic structure of SeMALT413 resembles the structure of S. pastorianus maltotriose-transporter gene SpMTY1, which has high sequences identity to alternatingly S. cerevisiae MALx1, S. paradoxus MALx1 and S. eubayanus SeMALT3. Evolution of the maltotriose transporter landscape in hybrid S. pastorianus lager-brewing strains is therefore likely to have involved mechanisms similar to those observed in the present study.