gebhart/patrepeval huggingface dataset:
Amino Acid Sequence Studies on the Tryptic Peptides of the Coat Protein of the Bacteriophage R17<sup>*</sup> (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmino Acid Sequence Studies on the Tryptic Peptides of the Coat Protein of the Bacteriophage R17*Klaus WeberCite this: Biochemistry 1967, 6, 10, 3144–3154Publication Date (Print):October 1, 1967Publication History Published online1 May 2002Published inissue 1 October 1967https://pubs.acs.org/doi/10.1021/bi00862a023https://doi.org/10.1021/bi00862a023research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Eplerenone Attenuates Myocardial Fibrosis in the Angiotensin II-Induced Hypertensive Mouse: Involvement of Tenascin-C Induced by Aldosterone-Mediated Inflammation (2007)

Tenascin-C is an extracellular matrix glycoprotein that is supposed to be a profibrotic molecule in various fibrogenic processes. To elucidate its significance for myocardial fibrosis in the hypertensive heart, we used a mouse model with infusion of angiotensin II and examined results by histology, immunohistochemistry, in situ hybridization, and quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR). Angiotensin II treatment elevated blood pressure and expression of tenascin-C by interstitial fibroblasts in perivascular fibrotic lesions, and angiotensin II infusion caused accumulation of macrophages. It also upregulated expression of collagen Ialpha2; IIIalpha1; and proinflammatory/profibrotic mediators including transforming growth factor beta (TGFbeta), platelet-derived growth factor alpha (PDGF-A), PDGF-B, and PDGF-receptor alpha, but not IL-1beta and PDGF-receptor beta, in the myocardium. Treatment with an aldosterone receptor antagonist, eplerenone, significantly attenuated angiotensin II-induced fibrosis, expression of tenascin-C, and inflammatory changes without affecting the blood pressure level. In vitro, neither eplerenone nor aldosterone exerted any influence on tenascin-C expression of cardiac fibroblasts, whereas angiotensin II, TGF-beta1, and PDGF significantly upregulated expression of tenascin-C. These results suggest that, in the angiotensin II-induced hypertensive mouse heart: (1) tenascin-C may be involved in the progression of cardiac fibrosis and (2) aldosterone may elicit inflammatory reactions in myocardium, which might, in turn, induce tenascin-C synthesis of fibroblasts through at least 2 pathways mediated by TGF-beta and PDGF-A-B/PDGF-receptor alpha.
Review article: remission rates achievable by current therapies for inflammatory bowel disease (2011)

In the era of biologics, the proportion of patients with inflammatory bowel disease not entering remission remains high.
Scalability for an Alternative Rolling Traction CVT (2004)

<div class="htmlview paragraph">A new rolling traction CVT design based on spherical torque transfer components has been developed by Motion Technologies, LLC. Improved efficiencies and significantly improved power densities have been demonstrated. Ratio control of this CVT is very simple, in contrast with more complex controls required for other rolling traction type CVTs.</div> <div class="htmlview paragraph">Both the single cavity and dual cavity designs of the Motion CVT have coaxial input and output shafts. The input and/or output may also be offset to accommodate other automobile drivelines. These characteristics, combined with low manufacturing cost, make the Motion CVT a very reasonable option for automotive and other vehicle applications.</div>
Adaptive mesh subdivision for precomputed radiance transfer (2004)

In precomputed radiance transfer (PRT), the radiance transfer operator is precomputed on vertices of a mesh. During rendering the transfer operator is combined with illumination to produce global illumination effects at real-time frame rates. However, visible error can be introduced by interpolating the transferred radiance between vertices. We propose to adaptively subdivide meshes with PRT in order to avoid the interpolation error. The mesh density is increased where the transferred radiance can change rapidly and introduce high error. We exploit the fact that the illumination frequency in PRT is bounded and thus we are able to perform the subdivision during the preprocessing phase. This obviates the need for dynamic mesh subdivision at render-time. The adaptive subdivision is guided by an error measure based on the transfer operator.
FIELD-BASED SIMILARITY FORCING IN ENERGY MINIMIZATION AND MOLECULAR MATCHING (1998)

A new field-based similarity forcing procedure for matching conformationally-flexible molecules is presented. The method extends earlier work on similarity matching of molecules based upon the program MIMIC, by directly coupling a similarity function to a molecular mechanics force field. In this way conformational energetics are fully accounted for in the similarity matching process. Simultaneous similarity/conformational searches can then be undertaken within a Monte Carlo or molecular dynamics framework. Here, a Monte Carlo approach is used to provide a simple example of two HIV-1 reverse transcriptase inhibitors, nevirapine and alpha APA, that illustrates the basic characteristics of the method and suggests areas for further investigation.
Surface modification of III-V compound semiconductors using surface electromagnetic wave etching induced by ultraviolet lasers (1995)

The surface modification of semiconductors by laser-induced surface electromagnetic wave (SEW) etching was investigated. With the novel etching method using a holographic exposure system, submicron periodic dot structures were fabricated directly on semiconductor substrates (n-InP, n-GaAs, and InGaAs-InP). Making use of laser polarization dependence in this etching system, a variety of surface modifications could be achieved on the semiconductors. In particular, in the case of using the s-polarization light, periodic submicron dot structures with a geometrical diameter down to 80 nm could be obtained directly using a single-step process without a mask. The InGaAs-InP dot structures were studied optically by means of photoluminescence spectroscopy, and the blue shift of the photoluminescence energy up to 5.36 meV was observed for the smallest dots, which displayed a lateral quantization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Autosomal dominant parkinsonism associated with variable synuclein and tau pathology (2004)

Since the original 1995 report of a parkinsonian kindred, four individuals have been affected (mean age at onset, 65 years). All four had cardinal signs of Parkinson disease (PD) and good response to levodopa. Four autopsies showed neuronal loss and gliosis in the substantia nigra. Lewy bodies (LB) limited to brainstem nuclei were detected in one case, diffuse LB in the second, neurofibrillary tangles (NFT) without LB in the third, and neither NFT nor LB in the fourth. Genetic studies suggested linkage to the PARK8 locus on chromosome 12.
Using Suffix Arrays to Compute Term Frequency and Document Frequency for All Substrings in a Corpus (1998)

Americanae nace como un proyecto conjunto que surge dentro de la Red Europea de Información y Documentación sobre América Latina (REDIAL), y que ha afrontado la Biblioteca de la Agencia Española de Cooperación Internacional para el Desarrollo (AECID). Esta nueva biblioteca virtual hace más accesibles los libros digitales de tema americanista a los investigadores y usuarios interesados de cualquier parte del mundo.
Two-Step Hantzsch Based Macrocyclization Approach for the Synthesis of Thiazole-Containing Cyclopeptides (2010)

Macrocyclization via an efficient high-yielding solid-phase intramolecular thioalkylation reaction is described. The reaction of S-nucleophiles with newly generated N-terminal 4-chloromethyl thiazoles led to the desired macrocyclization products 5 in high purities and good overall yields.
Headache: classification, mechanism and principles of therapy, with particular reference to migraine. (1989)

The sensation of pain derived from intracranial and extracranial blood vessels is conveyed to the central nervous system chiefly by the trigeminal nerve, with first order neurones terminating in the nucleus caudalis of the spinal trigeminal tract and an area lateral to the dorsal horn of the spinal cord at the second cervical segment. The evoked discharge of second order neurons can be suppressed by activation of the endogenous pain control system or, in about one third of cases, by the local application of ergot derivatives or the serotonin (5HT1) agonist sumatriptan (GR43175). Stimulation of brainstem structures such as locus ceruleus, raphe nuclei and the trigeminal system induce changes in the cerebral and extracranial circulations of the experimental animal that mimic those of migraine with aura (classical migraine). Clinical and laboratory observations have led to a neural hypothesis for migraine in which changes in hypothalamic function (an 'internal clock') and reactions to stress or excessive afferent stimuli are thought to initiate brainstem activity, causing secondary vascular changes and release of inhibition of the trigeminal pain pathways to cause headache. Painful distension of cranial blood vessels may contribute the throbbing component to migraine headache. Migraine is associated with a lowered level of platelet serotonin that is thought to reflect monoamine depletion in brainstem nuclei. Migraine headache can be precipitated by reserpine, which releases serotonin from body stores, and relieved by the intravenous infusion of serotonin. The new 5HT1 agonist sumatriptan promises to have the beneficial effects of serotonin without the side-effects that limited its clinical use.(ABSTRACT TRUNCATED AT 250 WORDS)
The hydrogenation of nitroarenes mediated by platinum nanoparticles: an overview (2014)

This review reports the most recent advances in the synthesis and application of platinum nanoparticles as catalysts in the hydrogenation reaction of nitroaromatics.
Novel Combination Strategies to Repair the Injured Mammalian Spinal Cord (2008)

Due to the varied and numerous changes in spinal cord tissue following injury, successful treatment for repair may involve strategies combining neuroprotection (pharmacological prevention of some of the damaging intracellular cascades that lead to secondary tissue loss), axonal regeneration promotion (cell transplantation, genetic engineering to increase growth factors, neutralization of inhibitory factors, reduction in scar formation), and rehabilitation. Our goal has been to find effective combination strategies to improve outcome after injury to the adult rat thoracic spinal cord. Combination interventions tested have been implantation of Schwann cells (SCs) plus neuroprotective agents and growth factors administered in various ways, olfactory ensheathing cell (OEC) implantation, chondroitinase addition, or elevation of cyclic AMP. The most efficacious strategy in our hands for the acute complete transection/SC bridge model, including improvement in locomotion [Basso, Beattie, Bresnahan Scale (BBB)], is the combination of SCs, OECs, and chondroitinase administration (BBB 2.1 vs 6.6, 3 times more myelinated axons in the SC bridge, increased serotonergic axons in the bridge and beyond, and significant correlation between the number of bridge myelinated axons and functional improvement). We found the most successful combination strategy for a subacute spinal cord contusion injury (12.5-mm, 10-g weight, MASCIS impactor) to be SCs and elevation of cyclic AMP (BBB 10.4 vs 15, significant increases in white matter sparing, in myelinated axons in the implant, and in responding reticular formation and red and raphe nuclei, and a significant correlation between the number of serotonergic fibers and improvement in locomotion). Thus, in two injury paradigms, these combination strategies as well as others studied in our laboratory have been found to be more effective than SCs alone and suggest ways in which clinical application may be developed.
IEA Bioenergy Task 40 - Global Wood Pellets and Woodchips Market and Ttrade Study: Preliminary Results (2011)

This paper presents the first preliminary results of a study conducted by IEA Bioenergy Task 40 “Sustainable Bioenergy Trade” and still ongoing about the trends in the global wood pellet market as well as the status and prospects for woodchip trade for energy purposes. The wood pellet market has experienced a large growth in the last five years. in 2009 the estimated consumption was above 12 million tons. The European Union is still the main market for pellet consumption (10.4 million tons in 2009) and will remain such for the next several years. Sawdust is still the main raw material for the production of wood pellets, however the interest of producers in the supply of alternative feedstock such as round-wood and forest residues is growing. The rapid growth of the market is driven by different factors related to the different market segments, however they are still quite dependent on the availability of direct or indirect support measures. the rise of the demand in EU is stimulating large investments in new pellet plants and a rapidly increasing production capacity in countries such as Canada, U.S. and the Russian Federation. Although wood chips are traditionally traded locally on small distances, international trade flows are also becoming significant. i.e. in the Baltic sea area and in Southern Europe, but little is known on trade routes, prices and market drivers. In 2009, the wood chips and particles world production was evaluated at about 216 million m3 (Faostat). America is by far the greatest producer (46% of the world production), followed by Europe (27%), Asia (12%), Oceania (9%) and Africa (6%).
A Candidate Target for G Protein Action in Brain (1999)

An effector candidate for G protein action, GRIN1, was identified by screening a cDNA expression library with phosphorylated GTPgammaS-G(z)alpha as a probe. GRIN1 is a novel protein without substantial homology to known protein domains. It is expressed largely in brain and binds specifically to activated G(z)alpha, G(o)alpha, and G(i)alpha through its carboxyl-terminal region. The protein KIAA0514 (GRIN2) is homologous to GRIN1 at its carboxyl terminus and also binds to activated G(o)alpha. Both GRIN1 and G(o)alpha are membrane-bound proteins that are enriched in the growth cones of neurites. Coexpression of GRIN1 or GRIN2 with activated G(o)alpha causes formation of a network of fine processes in Neuro2a cells, suggesting that these pathways may function downstream of G(o)alpha to control growth of neurites.
Outbreak of haemolytic uraemic syndrome in Norway: update (2006)

As of 6 April 2006, 10 cases of haemolytic uraemic syndrome, six cases of diarrhoea and one case of asymptomatic infection linked to an outbreak, which began in February, have been notified in Norway
Stability and availability of cyclosporine stored in plastic syringes (1986)

The stability and availability of cyclosporine from the oral dosage form when stored in plastic syringes were examined. Solutions of cyclosporine were stored in plastic syringes for 28 days at 25 degrees C. Half of the solutions remained in room light, and samples were obtained at 3, 6, and 12 hours and 1, 2, 3, 4, 5, 6, 7, 14, 21, and 28 days. The remaining samples were protected from light, and samples were obtained at 1, 3, 5, 7, 14, 21, and 28 days. Samples stored in plastic were compared with control solutions stored in the original amber bottle. All samples were analyzed for unchanged cyclosporine by high-pressure liquid chromatography. Cyclosporine was stable and completely available from the oral dosage form when stored in plastic syringes for up to 28 days. There was no difference in the stability of cyclosporine between the solutions exposed to room light and those protected from light. Solutions of the oral dosage form of cyclosporine may be stored in plastic syringes without protection from light for up to 28 days.
Effects of the kinetics of osmotic pressure variation on yeast viability (1992)

The variation rate of the osmotic pressure increase was found to have a great effect on the viability of yeasts subjected to hyperosmotic stress. A low intensity of the increase rate of osmotic pressure could maintain an important viability of the cells (about 90 to 100%) even for very high levels of osmotic pressure (about 10(8) Pa). The viability level was found to be highly dependent on the physiological state of the cells: Variations in the properties of the cell membrane were supposed to be involved in such a dependence.
Assessment of the universality and utility of a set of conserved mitochondrial COI primers in insects (1997)

A set of mitochondrial COI primers has been studied by genomic PCR and many primer combinations shown to work universally well across Insecta. They are able to amplify various amplicons with different variability which enables the selection of a particular amplicon as a suitable DNA marker for a project. The potential usefulness of different amplicons is examined, with analysis on published study cases employing these regions. With respect to their variability, amplicons UEA5/UEA6, UEA7/UEA8 and UEA5/UEA8 could be useful for low- to mid-level phylogenetic analysis, i.e. from species, genus to perhaps family level depending on taxa involved. UEA5/UEA6 will be too conserved for intraspecific studies. Amplicons UEA3/UEA4 and UEA9/UEA10 would be better suited to low-level phylogenetic investigations, such a analysis of relationships among closely related species and population genetic studies. However, these guidelines should not be over-generalized for the reasons given. Amplification conditions of various primer combinations, and general problems in the use of conserved PCR primers are discussed.
Transformation ability of fungi isolated from cork and grape to produce 2,4,6-trichloroanisole from 2,4,6-trichlorophenol (2008)

The ability of eight fungal strains to transform 2,4,6-trichlorophenol (TCP) to 2,4,6-trichloroanisole (TCA) was studied. These fungi were isolated from cork, belonging to the genera Penicillium, Aspergillus, Trichoderma and Chrysonilia, and from grapes Botrytis cinerea. All, except Chrysonilia, produced TCA when grown directly on cork in the presence of TCP, Aspergillus and Botrytis cinerea being the ones with the highest level of production. It is the first time that Botrytis cinerea, a microorganism often present on grapes and in winery environments, has been shown to transform TCP into TCA. This result can partially explain the wine cork taint before being bottled.
Signal detection and classification using matched filtering and higher order statistics (1990)

A method for signal detection and classification in the presence of additive Gaussian noise using higher-than-second-order statistics of the matched filter output is presented. Deterministic and random, nonGaussian distributed signals are detected via multiple correlations and cumulants, respectively. The detection algorithm is computationally simple, and, contrary to standard matched filtering, it is insensitive to signal shifts and does not require knowledge of the noise spectrum for prewhitening. The detector can be viewed as a likelihood radio test between sampled higher-order statistics, and its performance is evaluated using binary hypothesis testing. Signals are designed to have equal higher-order correlation energies and then classified based on higher-order statistics. Two-dimensional extensions of the one-dimensional algorithms are discussed briefly. Simulations illustrate successful performance of the detection and classification algorithms at low signal-to-noise ratio.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Electron-deficient truxenone derivatives and their use in organic photovoltaics (2014)

A series of electron-deficient truxenone derivatives are investigated as fullerene alternatives in organic photovoltaic applications.
Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI (2000)

A quantitative MR perfusion method showed reduced white matter CBF in patients with ischaemic leukoaraiosis, but normal grey matter CBF. This is consistent with hypoperfusion playing a part in the pathogenesis of ischaemic leukoaraiosis. The absolute values of white matter and grey matter CBF obtained in the patient groups were very similar to those in previous PET studies, providing further evidence for the validity of the regional CBF measurements obtained using this quantitative MR perfusion technique. The high spatial resolution and lack of radioactive administration makes such techniques ideal for longitudinal studies in this condition.
The Anti-Inflammatory Role of Minocycline in Alzheimers Disease (2016)

Alzheimer's disease (AD) is a neurodegenerative disorder where the main risk factor is age, since its incidence increases dramatically after the age of 60. It is the most common form of dementia, and is accompanied by memory loss and cognitive impairment. Although AD was discovered over a century ago, the only drugs approved by the US Food and Drug Administration for use in its treatment are four cholinesterase inhibitors and memantine. However, these drugs are not fully effective in the treatment of AD. Therefore, the incessant search for new methods of treating AD continues, with the hope of improving both the effectiveness of therapies and the quality of life for patients suffering with AD. Current evidence suggests that the antibiotic minocycline could be a potential therapeutic drug for use in the treatment of AD due to its anti-neuroinflammatory effects. Minocycline is a tetracycline derivative that combines an anti-inflammatory property that is capable of crossing the blood brain barrier with neuroprotective properties that work by limiting inflammation and oxidative stress. Several studies have established the presence of inflammatory markers in the brains of patients suffering with AD, including elevated levels of cytokines/chemokines and microgliosis in damaged regions. Cytokines have been associated with increased tau phosphorylation and decreased levels of synaptophysin, establishing their roles in the cytoskeletal and synaptic alterations that take place in AD. Therefore, pharmacological approaches that allow for the discovery and development of new anti-inflammatory agents such as minocycline will be welcomed in the continuing struggle against AD. Considering these facts, this review will discuss the anti-inflammatory mechanisms underlying the neuroprotective effects of minocycline as a novel therapeutic approach for the treatment of AD.