gebhart/patrepeval huggingface dataset:
A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk) (2009)

Fibroblast growth factors (FGFs) transduce signals through FGF receptors (FGFRs) and have pleiotropic functions. Besides signal-transducing FGFRs, cysteine-rich FGF receptor (Cfr; Glg1) is also known to bind some FGFs, although its physiological functions remain unknown. In this study, we generated Cfr-deficient mice and found that some of them die perinatally, and show growth retardation, tail malformation and cleft palate. These phenotypes are strikingly similar to those of Fgf18-deficient mice, and we revealed interaction between Cfr and Fgf18 both genetically and physically, suggesting functional cooperation. Consistently, introduction of Cfr facilitated Fgf18-dependent proliferation of Ba/F3 cells expressing Fgfr3c. In addition, we uncovered binding between Cfr and delta-like protein (Dlk), and noticed that Cfr-deficient mice are also similar to Dlk-transgenic mice, indicating that Cfr and Dlk function in opposite ways. Interestingly, we also found that Dlk interrupts the binding between Cfr and Fgf18. Thus, the Fgf18 signaling pathway seems to be finely tuned by Cfr and Dlk for skeletal development. This study reveals a novel regulatory mechanism for Fgf18 signaling involving Cfr and Dlk.
Histological changes in experimental periodontal disease in gnotobiotic rats and conventional hamsters (1974)

Seventy‐six weanling gnotobiotic rats of the Sprague‐Dawley strain were monoinfected in groups with Actlnomyces naeslundii, Actinomyces viscosus or Streptococcus mutans. The animals were killed at intervals up to 84 days and the maxillae and mandibles examined histologically. Periodontal disease, as evidenced by the presence of plaque, migration of the epithelial attachment and regression of the alveolar bone was sometimes evident after 28 days and in all cases extreme by 84 days. No organisms were seen in the gingiva and inflammatory changes were slight. Periodontal disease was most marked between the first and second maxillary molars, the mandibular gingiva, apart from the presence of plaque, being normal over the experimental period. Bone loss was gauged by labelling the bone with 3 H proline, and osteoclasts were detected by the acid phosphatase technique. In another experiment, 44 conventional weanling cream hamsters were superinfected with A. naeslundii . Periodontal disease developed more slowly than in the gnotobiotic rats, usually taking about 160 days to be severe. In both experiments the pathological changes were similar. The gnotobiotic rats developed periodontal disease over the same time sequence with all three organisms. Bone loss was not accompanied by the presence of osteoclasts and seemed, in this model, to be more due to a gradual cessation of bone formation than to active resorption. If in addition bone resorption did occur, it was brought about by a mechanism at present undescribed.
Depth accuracy of the RealSense F200: Low-cost 4D facial imaging (2017)

The RealSense F200 represents a new generation of economically viable 4-dimensional imaging (4D) systems for home use. However, its 3D geometric (depth) accuracy has not been clinically tested. Therefore, this study determined the depth accuracy of the RealSense, in a cohort of patients with a unilateral facial palsy (n = 34), by using the clinically validated 3dMD system as a gold standard. The patients were simultaneously recorded with both systems, capturing six Sunnybrook poses. This study has shown that the RealSense depth accuracy was not affected by a facial palsy (1.48 ± 0.28 mm), compared to a healthy face (1.46 ± 0.26 mm). Furthermore, the Sunnybrook poses did not influence the RealSense depth accuracy (p = 0.76). However, the distance of the patients to the RealSense was shown to affect the accuracy of the system, where the highest depth accuracy of 1.07 mm was measured at a distance of 35 cm. Overall, this study has shown that the RealSense can provide reliable and accurate depth data when recording a range of facial movements. Therefore, when the portability, low-costs, and availability of the RealSense are taken into consideration, the camera is a viable option for 4D close range imaging in telehealth.
<i>Escherichia coli</i> O157[ratio ]H7 diarrhoea associated with well water and infected cattle on an Ontario farm (1998)

A 16-month old female child living on an Ontario dairy farm was taken to hospital suffering from bloody diarrhoea. Escherichia coli O157:H7 was isolated from her stool. Initial tests of well water samples were negative for E. coli by standard methods but culture of selected coliform colonies on sorbitol-MacConkey agar led to isolation of E. coli O157:H7. E. coli O157:H7 was also isolated from 63% of cattle on the farm. The E. coli O157:H7 isolates from the child, the water and the cattle were phage type 14, produced verotoxins 1 and 2, and were highly related on analysis by pulsed field gel electrophoresis. The child did not have known direct contact with the cattle and did not consume unpasteurized milk. Hydrogeological investigation revealed the design and location of the well would allow manure-contaminated surface water to flow into the well. This investigation demonstrates that cattle farm well water is a potential source of E. coli O157:H7 which may not be identified by standard screening for E. coli in water.
Discovery of a bacterial gene cluster for catabolism of the plant hormone indole 3-acetic acid (2008)

The isolation and annotation of an 8994-bp DNA fragment from Pseudomonas putida 1290, which conferred upon P. putida KT2440 the ability to utilize the plant hormone indole 3-acetic acid (IAA) as a sole source of carbon and energy, is described. This iac locus (for indole 3-acetic acid catabolism) was identified through analysis of a plasposon mutant of P. putida 1290 that was no longer able to grow on IAA or indole 3-acetaldehyde and was unable to protect radish roots from stunting by exogenously added IAA. The iac locus consisted of 10 genes with coding similarity to enzymes acting on indole or amidated aromatics and to proteins with regulatory or unknown function. Highly similar iac gene clusters were identified in the genomes of 22 bacterial species. Five of these, i.e. P. putida GB-1, Marinomonas sp. MWYL1, Burkholderia sp. 383, Sphingomonas wittichii RW1 and Rhodococcus sp. RHA1, were tested to confirm that bacteria with IAA-degrading ability have representatives in the Alpha-, Beta- and Gammaproteobacteria and in the Actinobacteria. In P. putida 1290, cat and pca genes were found to be essential to IAA-degradation, suggesting that IAA is channeled via catechol into the beta-ketoadipate pathway. Also contributing to the IAA degrading phenotype were genes involved in tricarboxylate cycling, gluconeogenesis, and carbon/nitrogen sensing.
A‐D‐A Type Small Molecules Based on Boron Dipyrromethene for Solution‐Processed Organic Solar Cells (2015)

The unique properties of boron dipyrromethene (BODIPY) dyes including facile synthesis, high absorption coefficients, and delocalized molecular orbitals as well as excellent photochemical and thermal stability, make them promising as materials for organic solar cells. Accordingly, in this study three A-D-A structural small molecules of BDTT-BODIPY, FL-BODIPY, and TT-BODIPY have been synthesized, in which two BODIPY acceptor units are symmetrically conjugated to 4,8-bis(5-(2-ethylhexyl) thiophen-2-yl)benzo[1,2-b:4,5-b]dithiophene (BDTT), 9,9-dioctyl-9H-fluorene (FL), and thieno[3,2-b]thiophene (TT) donor cores, respectively. The manipulation of the structural parameters significantly improves the performances of the BHJ OSCs, which show power conversion efficiencies of 4.75%, 1.51%, and 1.67% based on [6,6]-phenyl C71 -butyric acid methyl ester (PC71 BM) as the acceptor material and BDTT-BODIPY, FL-BODIPY, and TT-BODIPY as the donor materials, respectively.
Impact of Library Automation in Nigerian Universities (2018)

Abstract This paper discuss about the impact of library automation in Nigerian universities. The term automation is introduced used first D.S. Harder in 1936. Harder defined automation as the handling of parts between progressive production processes. Nok (2006) observes that the success of automation in the university library depends largely on the ability of staff to facilitate and implement the process. Proper, frequent, and regular in-house information technology training is a necessity if the maximum benefit is to be gained from the automation of library services. In Nigeria universities, librarians are normally put in place of information and communication technology facilities to enhance the library automation process. And the use of automation in Nigeria University promotes the libraries in their daily routines. These encourage both librarians and clienteles in the library patronage and usage. Keywords: Automation, Library, Universities, Library Automation, Information and Communication Technology.
Luminescent Gold(I) Acetylides:  From Model Compounds to Polymers (1997)

The emission spectra of rigid-rod, conjugated polymeric complexes of gold(I) of the type [−Au−C⋮C−Ar−C⋮C−Au−L−L−]x, where Ar = aryl and L−L = diphosphine or bis(isocyanide) ligands are reported for the first time, along with the corresponding spectra of analogous mononuclear and binuclear alkynylgold(I) model complexes. It is found that the emission spectra display a red shift on going from mononuclear to binuclear to polynuclear structures, and it is tentatively argued that this provides evidence for extended π-conjugation in the polymers. Many of the model complexes display a red shift in the emission spectra on going from solution in dichloromethane to the solid state; in most cases, this is attributed to the presence of intermolecular Au···Au bonding in the solid state but, in one case, it is also observed when the intermolecular Au···Au distance is too long to be consistent with a bonding interaction. Assignments of the emission spectra are aided by EHMO (extended Hückel molecular orbital) calculations on model complexes. Structures of the model complexes [Me3P−Au−C⋮C−C6H2Me2−C⋮C−Au−PMe3], the first digold diacetylide to be structurally characterized, and [XyN⋮C−Au−C⋮C−C6H4−NO2] have been determined crystallographically.
Radiochemical determination of plutonium in environmental and biological samples by ion exchange (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRadiochemical determination of plutonium in environmental and biological samples by ion exchangeN. A. TalvitieCite this: Anal. Chem. 1971, 43, 13, 1827–1830Publication Date (Print):November 1, 1971Publication History Published online1 May 2002Published inissue 1 November 1971https://doi.org/10.1021/ac60307a025Request reuse permissionsArticle Views258Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (533 KB) Get e-Alertsclose Get e-Alerts
Impairment of left atrial function predicts post-operative atrial fibrillation after coronary artery bypass graft surgery (2004)

Despite the prevalence of atrial fibrillation (AF) occurring after cardiac surgery, its pathophysiology is incompletely understood. Specifically, whether left atrial (LA) structural remodelling occurs, contributing to a decrement in atrial function and AF has not been previously determined. This study sought to determine the relationship between LA function and post-operative AF.Three hundred patients undergoing elective coronary artery bypass graft surgery were monitored with intraoperative transoesophageal echocardiography to determine LA function and dimensions. Post-operative AF was monitored with continuous telemetry until hospital discharge. The relationship between clinical factors versus LA function and dimension was assessed using multi-variate logistic regression. By univariate analysis, patients who subsequently developed post-operative AF had a larger LA area and LA appendage area, and lower LA ejection fraction measured in the pre-bypass period compared to those without subsequent AF. By multivariable analysis, in addition to clinical data including age (odds ratio [OR] 1.11, 95% confidence interval [CI] 1.05-1.16, P<0.0001), body surface area (OR 13.31, 95% CI 1.87-94.5, P=0.0097) and white race, post-bypass atrial systolic function (atrial filling fraction 0.36, OR 2.51, 95% CI 1.03-6.13, P=0.04) and abnormal relaxation of the left ventricle (E duration 270 ms) (OR 2.89, 95% CI 1.34-6.24, P=0.0067) independently increased the risk of post-operative AF.These results demonstrate that some of the structural and functional changes in the atria common to chronic AF in the elderly population are also prevalent in surgical patients who develop post-operative AF, suggesting that post-operative and chronic AF may have similar pathophysiology.
Thermodynamics of Chelation. I. The Statistical Factor in Chelate Ring Formation<sup>1</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermodynamics of Chelation. I. The Statistical Factor in Chelate Ring Formation1Clark G. Spike and Robert W. ParryCite this: J. Am. Chem. Soc. 1953, 75, 11, 2726–2729Publication Date (Print):June 1, 1953Publication History Published online1 May 2002Published inissue 1 June 1953https://pubs.acs.org/doi/10.1021/ja01107a053https://doi.org/10.1021/ja01107a053research-articleACS PublicationsRequest reuse permissionsArticle Views311Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermal and mechanical properties of polylactic acid (PLA) and bagasse carboxymethyl cellulose (CMCB) composite by adding isosorbide diesters (2015)

An isosorbide diesters is one of isororbide types used as a plasticizer. The influence of this plasticizer on thermal and mechanical properties of polylactic acid and bagasse carboxymethyl cellulose (PLA/CMCB) composites was studied. PLA was blended with CMCB at 1%wt using various contents of isosorbide diesters (5, 10, 15 and 20%wt of PLA). The differential scanning calorimetric (DSC) and thermogravimetric (TGA) analyses indicated that the increment of isosorbide diesters concentration resulted in decreasing glass transition, melting and decomposition temperatures, as well as the reduction of storage modulus of PLA/CMCB composites. Moreover, the elongation of PLA/CMCB composites was significantly improved with increasing plasticizer content.
Characterization of Self-Assembled Monolayers of Fullerene Derivatives on Gold Surfaces:  Implications for Device Evaluations (2006)

The widely employed approach to self-assembly of fullerene derivatives on gold can be complicated due to multilayer formations and head-to-tail assemblies resulting from the strong fullerene−fullerene and fullerene−gold interactions. These anomalies were not examined in detail in previous studies on fullerene self-assembled monolayers (SAMs) but were clearly detected in the present work using surface characterization techniques including ellipsometry, cyclic voltammetry (CV), and X-ray photoelectron spectroscopy (XPS). This is the first time that SAMs prepared from fullerene derivatives of thiols/thiol esters/disulfides have been analyzed in detail, and the complications due to multilayer formations and head-to-tail assemblies were revealed. Specifically, we designed and synthesized several fullerene derivatives based on thiols, thiol acetates, and disulfides to address the characterization requirements, and these are described and delineated. These studies specifically address the need to properly characterize and control fullerene−thiol assemblies on gold before evaluating subsequent device performances.
Quantitative and qualitative effects of douche preparations on vaginal microflora. (1992)

The use of povidone-iodine douches decreases the numbers of the dominant bacterial species beyond those expected with other douches. In some individuals, such changes may allow rapid proliferation of potential pathogens during this altered state, increasing the risk of associated infections.
Semi‐dry PhastTransfer detection of biotinylated cell surface molecules (1993)

The PhastTransfer system is a semi-dry electrophoretic unit designed to optimize the transfer of small amounts of protein. Because of its efficiency, we adapted the PhastTransfer system for the detection of labeled membrane molecules. Biotin was used as the membrane molecule label because it permitted the long-term storage of labeled lysates as well as the flexibility of derivatizing several different functional groups. After immunoaffinity separation using magnetic microspheres, the protein was electrophoretically separated with the PhastSystem and transferred with the PhastTransfer unit. Using an avidin-linked enzyme amplification system, less than 10 ng of loaded protein could be detected on the transfer membrane. Based on these findings, the PhastTransfer system is a fast, reproducible, and convenient method for the transfer of small quantities of labeled cell surface protein.
FK506 CONVERSION THERAPY IN PEDIATRIC LIVER TRANSPLANTATION (1994)

The safety and efficacy of conversion to FK506 after failing immunosuppression with cyclosporine was prospectively evaluated in 31 pediatric liver transplant recipients between April 1991 and March 1993. The patients, who ranged in age from 40 days to 14 years, accounted for 28 primary transplantations and 3 retransplantations. The initial immunosuppression regimen consisted of cyclosporine in combination with prednisone. The indications for conversion were acute or chronic rejection refractory to OKT3, Minnesota antilymphocyte globulin, or steroids (13 patients); hypertension (8 patients); inability to reach a therapeutic level of cyclosporine (6 patients); hirsutism (3 patients); and growth retardation (1 patient). After an average follow-up of 10 months (range, 2 to 25 months), 27 (87%) of the patients are alive and have functioning grafts. Of the 13 patients who were converted for refractory rejection, 9 are alive. Six of these 9 patients experienced a complete biochemical reversal of the rejection process within 3 months of conversion; 2 had a partial response to conversion, and 1 patient failed but underwent successful retransplantation. Three of the 4 patients who died did so without showing any improvement. The remaining 18 patients who were converted for various other reasons are alive and have functioning grafts. Of the 8 patients who developed hypertension on cyclosporine and prednisone, 6 experienced a resolution of this problem within 3 months of conversion. Three of the 18 children who underwent rescue therapy for reasons other than refractory rejection experienced rejection episodes after conversion to FK506. Two of these 3 children achieved resolution with either steroid therapy or an increased dosage of FK506, while the third child developed chronic rejection. The side effects of FK506 were generally minor and resolved by lowering the dose. Lymphoproliferative disease developed in 2 patients (6%). The present study suggests that FK506 is a relatively safe and effective rescue therapy for pediatric liver transplant recipients who have failed immunosuppression with cyclosporine. Longer follow-up is needed to assess the effect of FK506 on growth.
Hot-electron transport in 3-terminal devices based on magnetic tunnel junctions (2002)

International audience
Capless LDO Regulator Achieving −76 dB PSR and 96.3 fs FOM (2016)

The performance of switching devices such as display driver ICs is degraded by large power supply noise at switching frequencies from a few hundreds of kilohertz to a few megahertz. In order to minimize the power supply noise, a low-dropout (LDO) regulator with higher power supply rejection (PSR) is essential. In this brief, a capless LDO regulator with a negative capacitance circuit and voltage damper is proposed for enhancing PSR and figure of merit (FOM), respectively, in switching devices. The proposed LDO regulator is fabricated in a 0.18 μm CMOS. Measurement results show that the proposed LDO regulator achieves -76 dB PSR at 1 MHz and 96.3 fs FOM with a total on-chip capacitance of as small as 12.7 pF.
DNA Methylation: An Alternative Pathway to Cancer (2001)

DNA methylation is an important factor in the development of cancer. A greater understanding of the relationship between DNA methylation events at the molecular level and its interaction in the clinical context may provide the basis for future advances in the surgical and pharmacologic management of malignant diseases.
Accurately locating plugged perforations in a well-treating method. [radioactive tracer techniques] (1966)

A method is described for locating the sections of a perforated casing which are taking treatment fluid. During the treatment operation, rubber balls containing radioactive slugs are introduced into the casing. These balls will lodge in those perforations through which the treatment fluid is flowing. This raises the pressure on the remaining non-flowing perforations, causing them to be forced open. A sonde, provided with thermometer and radiation detector means, can be used to locate the rubber balls as well as provide information relative to which perforations are being treated. (6 claims)
An Interferometer for Precision Angle Measurements (1963)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. Rohlin, "An Interferometer for Precision Angle Measurements," Appl. Opt. 2, 762-763 (1963) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Failure analysis of bond pad metal peeling using FIB and AFM (1998)

Aluminum bond pads on semiconductor chips play an important role in chips functionality and reliability. Bond pad peeling during wire bonding process results in yield reduction. The failure mechanisms of the peeling must be identified so that potential reliability problem of poor bond pad adhesion can be avoided. In this work, FIB, SEM, EDX, and AFM are used to identify the root causes of the peeling. The possible root causes are found to be the presence of an extra layer of thickness of 0.14 μm and the poly-silicon surface roughness asperity due to prolonged BOE etching time.