gebhart/patrepeval huggingface dataset:
Biochemical studies on dacron arterial prostheses. (1976)

Dacron arterial prostheses, treated or not with biopolymers (gelatin, glycosaminoglycans) were implanted in the abdominal aorta of dogs and the connective tissue synthetised inside and outside the prosthesis was studied. After 3 and 9 months of implantation the prosthesis, a joining portion and a piece of aorta were excised and put in organ culture with 14C-lysine for 3 days. Representative macromolecular extracts were then obtained by a "chemical dissection" procedure. The radioactivity and the chemical composition of these extracts was studied. The DNA content of the prosthesis was higher than that of the adjacent aorta showing a dense cellular repopulation of the prosthesis. This was confirmed by histology also which revealed the presence of a newly formed limiting elastic membrane and the presence of numerous elastic fibrils. Collagen, elastin and glycosaminoglycans could be detected in the macromolecular extracts showing that the cells which repopulated the prosthesis expressed a complete biosynthetic capacity as far as matrix macromolecules are concerned. The distribution of proteins in the extracts was as follows: 4% of total proteins were extracted in a 1M CaCl2-buffer 80% of total proteins in the collagenase extracts, 10% in the 6M urea extract. Only 0,2% of proteins were in the final elastase extract, 10 times less than in the joining aorta fragment. The proportion of the other proteins was similar in aorta and in the prosthesis as well as the chemical composition (hexosamine and hydroxyproline content) of the extracts. The proportion of collagenase-extractable proteins decreased with the time of implantation (from 3 to 9 months) and the proportion of urea-extractable proteins increased. This type of modification is similar to that found in aging aorta wall. 14C-lysine was actively incorporated in all macromolecular fractions studied. The incorporation pattern of the prothesis tissue was similar to that found for the joining host aorta, showing a similar regulatory tendency for matrix macromolecules. It appears therefore that a valid hemocompatible vascular type of connective tissue can be synthesised on the dacron arterial prosthesis and nature of this connective tissue can be influenced by previous biopolymer treatment of the synthetic prosthesis. The described procedure (incorporation of labelled precursors in organ culture) appears to be a valid method for the exploration of the regulatory processes underlying the synthetic capacity for matrix macromolecules of the newly formed tissue in the synthetic prosthesis.
Feasibility of magnetic fiber-optic based corrosion sensor (2017)

A fiber optic based corrosion sensor utilizing the magnetic interaction force is proposed. The sensor aims to detect corrosion in structures, which are made from ferromagnetic materials (e.g. pipelines made of carbon steel). It consists of a beam that is made from a non-corrosive material with embedded Fiber Bragg Grating (FBG) sensor and a permanent magnet. The beam is placed in a position such that the permanent magnet is within a few millimeters away from the ferromagnetic material to allow for the generation of the magnetostatic attraction force between the sensor and the pipe. The corrosion causes a reduction in material thickness, which increases the distance between the material and the magnet, thus the attraction force will decrease. This change in the force can be related directly to the change in the strain measured by the optical fiber as it causes a shift in the wavelength of the reflected light. We present initial analytical investigation of the feasibility of the proposed concept for practical application of monitoring the external corrosion process on the exposed pipelines. The estimated magnitude of strain change due to corrosion is within the measurement range of typical FBG strain sensors.
Polysaccharide‐based vaccine delivery systems: Macromolecular assembly, interactions with antigen presenting cells, and <i>in vivo</i> immunomonitoring (2009)

Using a strategy of macromolecular assembly, a colloidal vaccine delivery system was obtained from chitosan and dextran sulfate and loaded with an antigenic protein (p24, the capsid protein of HIV-1). The colloidal polyelectrolyte complexes (PECs) were obtained by charge neutralization of the polyanion and polycation at a charge ratio (n(+)/n(-)) of 2 (CHDS). The conditions of assembly were tuned to maintain the colloidal properties of the carrier in high salt environment. The relative molar masses of the two polyions and the degree of acetylation (DA) of chitosan were essential parameters to achieve this goal, and this could be related to the nanometric scale organization of the colloids observed by Small Angle X-rays Scattering experiments. The binding of p24 to the colloidal carrier was achieved and the release of the antigen was investigated. Antigen presenting cells [dendritic cells (DCs)], obtained from monocytes, could internalize the colloids. Immature DCs (iDCs) were not matured by the colloidal PECs either loaded or not loaded with p24, as proved by Fluorescent Activated Cell Sorting (FACS) analysis. Despite this lack of in vitro interaction, a specific immune response was observed in mice with a high production of antibodies, after subcutaneous injection. The analysis of the interleukin production shows that both the cellular and the humoral responses were stimulated. This work brings a physico-chemical insight on polysaccharide-based antigen delivery systems and opens up new perspectives for their use as vaccine carriers.
Genomic prediction in an admixed population of Atlantic salmon (Salmo salar) (2014)

Reliability of genomic selection (GS) models was tested in an admixed population of Atlantic salmon, originating from crossing of several wild subpopulations. The models included ordinary genomic BLUP models (GBLUP), using genome-wide SNP markers of varying densities (1-220 k), a genomic identity-by-descent model (IBD-GS), using linkage analysis of sparse genome-wide markers, as well as a classical pedigree-based model. Reliabilities of the models were compared through 5-fold cross-validation. The traits studied were salmon lice (Lepeophtheirus salmonis) resistance (LR), measured as (log) density on the skin and fillet color (FC), with respective estimated heritabilities of 0.14 and 0.43. All genomic models outperformed the classical pedigree-based model, for both traits and at all marker densities. However, the relative improvement differed considerably between traits, models and marker densities. For the highly heritable FC, the IBD-GS had similar reliability as GBLUP at high marker densities (>22 k). In contrast, for the lowly heritable LR, IBD-GS was clearly inferior to GBLUP, irrespective of marker density. Hence, GBLUP was robust to marker density for the lowly heritable LR, but sensitive to marker density for the highly heritable FC. We hypothesize that this phenomenon may be explained by historical admixture of different founder populations, expected to reduce short-range lice density (LD) and induce long-range LD. The relative importance of LD/relationship information is expected to decrease/increase with increasing heritability of the trait. Still, using the ordinary GBLUP, the typical long-range LD of an admixed population may be effectively captured by sparse markers, while efficient utilization of relationship information may require denser markers (e.g., 22 k or more).
Hidróxidos dobles laminares: arcillas sintéticas con aplicaciones en nanotecnología (2012)

Los hidróxidos dobles laminares (HDLs) son estructuras sintéticas formadas por láminas de hidróxidos metálicos cargadas positivamente que son estabilizadas con aniones interlaminares. La presencia de grupos hidroxilo en las superficies de sus láminas y los aniones intercambiables los hace compuestos ideales para preparar productos de funcionalización o hibridación con moléculas orgánicas permitiendo la obtención de nuevos materiales en escala nanométrica que cubren una gama amplia de aplicaciones, desde materiales biológicamente compatibles hasta catalizadores o materiales para remediación ambiental. Este trabajo revisa las características químicas y estructurales de estos compuestos, los métodos de síntesis, sus productos de intercalación o funcionalización y presenta parte de las diversas áreas en que pueden ser aplicados con el fin de motivar el estudio y desarrollo de materiales basados en estas estructuras.
Safety and Efficacy of Antimicrobial Peptides against Naturally Acquired Leishmaniasis (2004)

Leishmaniases, which are important causes of morbidity and mortality in humans and dogs, are extremely difficult to treat. Antimicrobial peptides are rarely used as alternative treatments for naturally acquired parasitic diseases. Here we report that the acylated synthetic antimicrobial peptide Oct-CA(1-7)M(2-9) is safe and effective for treating naturally acquired canine leishmaniasis.
Advances in Time-Frequency Analysis of Biomedical Signals (1996)

The frequency content of many biomedical signals can change rapidly with time. Conventional Fourier spectral analysis techniques are insufficient for analyzing the time-varying spectral content of these signals. By mapping a one-dimensional function of time (or frequency), the time-frequency representation can localize the signal energy in both the time and frequency directions. It has been shown that many biomedical signal problems may benefit from time-frequency analysis. The objective of this paper is to review the advances in time-frequency analysis of biomedical signals. Relevant theoretical methodologies and practical considerations are introduced, and five application areas are reviewed: electroencephalography (EEG), electrocardiography, phonocardiography, electrogastrography, and electromyography.
Near-continuous-tone electronic color printing on low-sensitivity photographic materials (1991)

Two electronic exposure systems employing active-matrix addressed liquid crystal light modulators are described for printing on lowsensitivity photographic materials such as the new 3M Dry Silver Color and Mead Cycolor™ papers. The feasibility of using a liquid crystal light modulator to expose these new materials was first demonstrated on a system employing simple projection optics. The image quality, printing speed, and complexity of projection type systems make them poor candidates for low-cost video printers. A new Multiline Multilevel Scanned Printing System, which is especially well suited to printing with liquidcrystal light modulators, is described. This is a large-aperture digital technique using an incandescent light source. It can produce a near-continuous-tone color print on photographic materials in a single pass below the light modulator. The system is intrinsically insensitive to isolated defects in the modulator and can also easily accommodate corrections for single pixel and column defects. The system has been used to make prints on a variety of photographic materials varying by over three orders of magnitude in sensitivity. A figure of merit is introduced that can be used as a starting point when one is comparing various exposure schemes.
Novel Strategy for a Cocktail <sup>18</sup>F-Fluoride and <sup>18</sup>F-FDG PET/CT Scan for Evaluation of Malignancy: Results of the Pilot-Phase Study (2009)

Our pilot-phase prospective trial demonstrates that the combined (18)F/(18)F-FDG administration followed by a single PET/CT scan is feasible for cancer detection. This combined method opens the possibility for improved patient care and reduction in health care costs.
A Network Framework for Noisy Label Aggregation in Social Media (2017)

Xueying Zhan, Yaowei Wang, Yanghui Rao, Haoran Xie, Qing Li, Fu Lee Wang, Tak-Lam Wong. Proceedings of the 55th Annual Meeting of the Association for Computational Linguistics (Volume 2: Short Papers). 2017.
Delay/Fault-Tolerant Mobile Sensor Network (DFT-MSN): A New Paradigm for Pervasive Information Gathering (2007)

This paper focuses on the delay/fault-tolerant mobile sensor network (DFT-MSN) for pervasive information gathering. We develop simple and efficient data delivery schemes tailored for DFT-MSN, which has several unique characteristics, such as sensor mobility, loose connectivity, fault tolerability, delay tolerability, and buffer limit. We first study two basic approaches, namely, direct transmission and flooding. We analyze their performance by using queuing theory and statistics. Based on the analytic results that show the trade-off between data delivery delay/ratio and transmission overhead, we introduce an optimized flooding scheme that minimizes transmission overhead in flooding. Then, we propose two simple and effective DFT-MSN data delivery schemes, namely, the replication-based efficient data delivery scheme (RED) and the message fault tolerance-based adaptive data delivery scheme (FAD). The RED scheme utilizes the erasure coding technology in order to achieve the desired data delivery ratio with minimum overhead. It consists of two key components for data transmission and message management. The former makes the decision on when and where to transmit data messages according to the delivery probability, which is the likelihood that a sensor can deliver data messages to the sink. The latter decides the optimal erasure coding parameters (including the number of data blocks and the needed redundancy) based on its current delivery probability. The FAD scheme employs the message fault tolerance, which indicates the importance of the messages. The decisions on message transmission and dropping are made based on fault tolerance for minimizing transmission overhead. The system parameters are carefully tuned on the basis of thorough analyses to optimize network performance. Extensive simulations are carried out for performance evaluation. Our results show that both schemes achieve a high message delivery ratio with acceptable delay. The RED scheme results in lower complexity in message and queue management, while the FAD scheme has a lower message transmission overhead.
American Hegemony in an Unplanned World Order (2000)

1 The University of California, Davis
Activity of [Sm(C<sub>5</sub>Me<sub>5</sub>)<sub>3</sub>] in Ethylene Polymerization and Synthesis of [U (C<sub>5</sub>Me<sub>5</sub>)<sub>3</sub>], the First Tris(pentamethylcyclopentadienyl) 5f‐Element Complex (1997)

Abstract For corrigendum see DOI: 10.1002/anie.199713711
Absorption of Insulin from the Human Small Intestine (1968)

Insulin absorption from the human intestine without the necessity of suppressing the activity of pancreatic enzymes has been demonstrated in an adult male subject who survived total pancreatectomy. Following a large dose of insulin the fraction absorbed was small and the reason for this is discussed.
A New Synthesis of Acetals of Chloroacetaldehyde and Bromoacetaldehyde (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Synthesis of Acetals of Chloroacetaldehyde and BromoacetaldehydeEdward M. FilachioneCite this: J. Am. Chem. Soc. 1939, 61, 7, 1705–1706Publication Date (Print):July 6, 1939Publication History Published online1 May 2002Published inissue 6 July 1939https://pubs.acs.org/doi/10.1021/ja01876a021https://doi.org/10.1021/ja01876a021research-articleACS PublicationsRequest reuse permissionsArticle Views367Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Anti-inflammatory constituents of topically applied crude drugs. I. Constituents and anti-inflammatory effect of Eriobotrya japonica Lindl. (1986)

The ether-soluble fraction of EtOH extract from the leaves of Eriobotrya japonica LINDL.showed an anti-inflammatory effect when topically applied to rats. Ursolic acid, maslinic acid, methyl maslimate and euscaphic acid were isolated from the ether-soluble fraction. Maslinic acid was found to show an anti-inflammatory effect on carrageenan-induced edema and an inhibitory effect on histamine-induced ileum contraction.
Selective internalization of self-assembled artificial oil bodies by HER2<i>/neu</i>-positive cells (2010)

A novel delivery carrier was developed using artificial oil bodies (AOBs). Plant seed oil bodies (OBs) consist of a triacylglycerol matrix surrounded by a monolayer of phospholipids embedded with the storage protein oleosin (Ole). Ole consists of a central hydrophobic domain with two amphiphatic arms that extrude from the surface of OBs. In this study, a bivalent anti-HER2/neu affibody domain (ZH2) was fused with Ole at the C terminus. After overproduction in Escherichia coli, the fusion protein (Ole-ZH2) was recovered to assemble AOBs. The size of self-assembled AOBs was tailored by varying the oil/Ole-ZH2 ratio and pH to reach a nanoscale. Upon co-incubation with tumor cells, the nanoscale AOBs encapsulated with a hydrophobic fluorescence dye were selectively internalized by HER2/neu-overexpressing cells and displayed biocompatibility with the cells. In addition, the ZH2-mediated endosomal entry of AOBs occurred in a time- and AOB dose-dependent manner. The internalization efficiency was as high as 90%. The internalized AOBs disintegrated at the non-permissive pH (e.g. in acidic endosomes) and the cargo dye was released. Results of in vitro study revealed a sustained and prolonged release profile. Taken together, our findings indicate the potential of AOBs as a delivery carrier.
Introduction to applied quantum chemistry (McGlynn, S. P.; Vanquickenborne, L. G.; Kinoshita, M.; Carroll, D. G.) (1973)

ADVERTISEMENT RETURN TO ISSUEPREVBook and Media Revie...Book and Media ReviewNEXTIntroduction to applied quantum chemistry (McGlynn, S. P.; Vanquickenborne, L. G.; Kinoshita, M.; Carroll, D. G.)Yuh Kang Pan Cite this: J. Chem. Educ. 1973, 50, 6, A347Publication Date (Print):June 1, 1973Publication History Received3 August 2009Published online1 June 1973Published inissue 1 June 1973https://doi.org/10.1021/ed050pA347.1RIGHTS & PERMISSIONSArticle Views294Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (872 KB) Get e-Alerts Get e-Alerts
On using emoticons and lingoes for hiding data in SMS (2015)

SMS is widely used as a daily communication service among people around the world. As such, SMS is a suitable means that can be readily exploited for transferring secret messages between individuals in a less conspicuous way. In this paper, we present an investigation on the suitability of hiding secret message in SMS. The hidden data are represented as lingoes and emoticons which are frequently used by users in SMS and chat. As a result, a pre-shared list, which is common between the sender and receiver is used to embed, and later extract the secret message in SMS in a natural form. The proposed method is implemented and tested on Android based mobile device, and showed some desirable outcomes.
Technologies for Investigating the Physiological Barriers to Efficient Lipid Nanoparticle–siRNA Delivery (2013)

Small interfering RNA (siRNA) therapeutics have advanced from bench to clinical trials in recent years, along with new tools developed to enable detection of siRNA delivered at the organ, cell, and subcellular levels. Preclinical models of siRNA delivery have benefitted from methodologies such as stem-loop quantitative polymerase chain reaction, histological in situ immunofluorescent staining, endosomal escape assay, and RNA-induced silencing complex loading assay. These technologies have accelerated the detection and optimization of siRNA platforms to overcome the challenges associated with delivering therapeutic oligonucleotides to the cytosol of specific target cells. This review focuses on the methodologies and their application in the biodistribution of siRNA delivered by lipid nanoparticles.
Synergistic transcriptional activation by one regulatory protein in response to two metabolites (2002)

BenM is a LysR-type bacterial transcriptional regulator that controls aromatic compound degradation in Acinetobacter sp. ADP1. Here, in vitro transcription assays demonstrated that two metabolites of aromatic compound catabolism, benzoate and cis,cis-muconate, act synergistically to activate gene expression. The level of BenM-regulated benA transcription was significantly higher in response to both compounds than the combined levels due to each alone. These compounds also were more effective together than they were individually in altering the DNase I footprint patterns of BenM-DNA complexes. This type of dual-inducer synergy provides great potential for rapid and large modulations of gene expression and may represent an important, and possibly widespread, feature of transcriptional control.
Poly(dimethylsiloxane) Star Polymers Having Nanosized Silica Cores (2004)

Abstract Summary: Poly(dimethylsiloxane) (PDMS) star polymers having a nanosized silica particle as a core were prepared by reacting silica nanoparticles with monoglycidylether‐terminated poly(dimethylsiloxane). This star polymer was a hybrid material having an extremely high content of silica. The PDMS arms formed an organic domain to separate the silica particles and to prevent particle aggregation. The star polymers exhibited good thermal stability and high activation energy of their degradation reaction, in comparison to the linear PDMS polymer and the PDMS/silica blending materials. This star polymer can be used as a flame retardant for polymeric materials and this preparation technique can be applied to prepare other star polymers. An SEM image of poly(dimethylsiloxane) star polymers having nanosized silica particles as a core. magnified image An SEM image of poly(dimethylsiloxane) star polymers having nanosized silica particles as a core.