gebhart/patrepeval huggingface dataset:
Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain (1998)

ADP-ribosylation factors (ARFs) are small GTP-binding proteins that are regulators of vesicle trafficking in eukaryotic cells. GRP1 is a member of a family of ARF guanine-nucleotide-exchange factors that binds in vitro the lipid second messenger phosphatidylinositol 3,4, 5-trisphosphate [PtdIns(3,4,5)P3]. In order to study the effects of PtdIns(3,4,5)P3 on the function of GRP1, we have cloned the human homologue of GRP1, encoding for a protein which is 98.8% identical to mouse brain GRP1. Human GRP1 binds, via its pleckstrin homology (PH) domain, the inositol head group of PtdIns(3,4,5)P3, inositol 1, 3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4], with high affinity (Kd 32. 2+/-5.2 nM) and inositol phosphate specificity [Kd values for Ins(1, 3,4,5,6)P5, InsP6, Ins(1,3,4)P3 and Ins(1,4,5)P3: 283+/-32, >10000, >10000 and >10000 nM, respectively). Furthermore, GRP1 can accommodate addition of glycerol or diacetylglycerol to the 1-phosphate of Ins(1,3,4,5)P4, data that are consistent with its proposed role as a putative PtdIns(3,4,5)P3 receptor. To address whether GRP1 binds PtdIns(3,4,5)P3 in vivo, we have expressed a chimaera of green fluorescent protein (GFP) fused to the N-terminus of GRP1 in PC12 cells and, using confocal microscopy, examined its resultant localization in live cells. Stimulation with either nerve growth factor or epidermal growth factor (both at 100 ng/ml) results in a rapid, PH-domain dependent, translocation of GFP-GRP1 from the cytosol to the plasma membrane, which occurs with a time course that parallels the production of PtdIns(3,4,5)P3. This translocation is dependent on the activation of phosphatidylinositol 3-kinase, since it is inhibited by wortmannin (100 nM), LY294002 (50 microM) and by the co-expression with dominant negative p85. Taken together these data strongly suggest that GRP1 interacts in vivo with plasma membrane-located PtdIns(3,4,5)P3 and hence constitutes a true PtdIns(3,4,5)P3 receptor.
Characteristics of breast carcinomas missed by screening radiologists. (1997)

Missed cancers were statistically significantly lower in density and more often seen on only one of two views than detected cancers.
Brain Choline Acetyltransferase and Mental Function in Alzheimer Disease (1999)

Degeneration of the cholinergic system in vivo correlates with decreasing cognitive function in patients with AD.
Antibodies Recognizing Mycobacterium avium paratuberculosis Epitopes Cross-React with the Beta-Cell Antigen ZnT8 in Sardinian Type 1 Diabetic Patients (2011)

The environmental factors at play in the pathogenesis of type 1 diabetes (T1D) remain enigmatic. Mycobacterium avium subspecies paratuberculosis (MAP) is transmitted from dairy herds to humans through food contamination. MAP causes an asymptomatic infection that is highly prevalent in Sardinian T1D patients compared with type 2 diabetes (T2D) and healthy controls. Moreover, MAP elicits humoral responses against several mycobacterial proteins. We asked whether antibodies (Abs) against one of these proteins, namely MAP3865c, which displays a sequence homology with the β-cell protein zinc transporter 8 (ZnT8) could be cross-reactive with ZnT8 epitopes. To this end, Ab responses against MAP3865c were analyzed in Sardinian T1D, T2D and healthy subjects using an enzymatic immunoassay. Abs against MAP3865c recognized two immunodominant transmembrane epitopes in 52-65% of T1D patients, but only in 5-7% of T2D and 3-5% of healthy controls. There was a linear correlation between titers of anti-MAP3865c and anti-ZnT8 Abs targeting these two homologous epitopes, and pre-incubation of sera with ZnT8 epitope peptides blocked binding to the corresponding MAP3865c peptides. These results demonstrate that Abs recognizing MAP3865c epitopes cross-react with ZnT8, possibly underlying a molecular mimicry mechanism, which may precipitate T1D in MAP-infected individuals.
Motion sickness incidence induced by complex periodic waveforms. (1982)

Independent groups of up to 32 young men exposed in a standard seated posture to one of five conditions of vertical (Z axis) motion for up to 2 h. Exposure was less in the event of vomiting or a volunteer's voluntary withdrawal from the experiment. A control condition, sinusoidal motion of 0.17 Hz and 0.13 G R.M.S., provided the basis for comparison with the remaining four conditions, each produced by the sum of two sinusoids, the fundamental at 0.17 Hz plus the second or third harmonic. The conditions differed in the phase relationship of the fundamental and second harmonic, or in the relative acceleration levels of the two harmonic components. The predicted motion sickness incidence (MSI) for each sinusoid alone was calculated from a previously derived mathematical model and compared with the obtained MSIs. Certain motion conditions provoked unexpectedly high MSIs compared with the control condition. It was found that R.M.S. acceleration is not reliable as the sole predictor of MSI in complex motion. Further data must be obtained before accurate prediction of MSI in broadband motion will be possible.
Design of high-resolution Fourier transform lens (2007)

With the development of optical information processing, high-resolution Fourier transform lens has often been used in holographic data storage system, spatial filtering and observation of particles. This paper studies the optical design method of high-resolution Fourier transform optical lenses system, which could be used in particles observation and holographic data storage system. According to Fourier transform relation between object and its frequency plane and the theory of geometrical optics, the system with working wavelength 532nm and resolution 3μm was designed based on ZEMAX. A multi-configuration method was adopted to optimize the system's lenses. In the optical system, a diaphragm was placed at the system's spectrum plane and the system demanded a low vacuum to cut down the influences of atmosphere and other particles. The result of finite element analysis indicated that the influences of vacuum pumping to optics spacing and mirror surface shape very minor, and the imaging quality not being affected. This system has many advantages, such as simple structure, good image quality and a high resolution of 3μm. So it has a wide application prospect and can be used both in holographic data storage system and particles observation.
Chemical Enhancement of Metallized Zinc Anode Performance (1998)

Abstract Galvanic current delivered to reinforced concrete by a metallized zinc anode was studied relative to the humidity of its environment and periodic direct wetting. Current decreased quickly at low humidity to values unlikely to meet accepted cathodic protection criteria, but could be easily restored by direct wetting of the anode. Thirteen chemicals were screened for their ability to enhance galvanic current Such chemicals, when applied to the exterior surface of the anode, are easily transported by capillary action to the anode-concrete interface where they serve to maintain the interface conductive and the zinc electrochemically active. The most effective chemicals were potassium and lithium bromide, acetate, chloride and nitrate, which increased galvanic current by a factor of 2-15, depending on relative humidity and chloride contamination of the concrete. This new technique is expected to greatly expand the number of concrete structures which can be protected by simple galvanic cathodic protection. The use of lithium-based chemicals together with metallized zinc anode is also proposed for mitigation of existing problems due to ASR. In this case, lithium ion, which prevents or inhibits expansion due to ASR, can be readily injected into the concrete. A new process, electrochemical maintenance of concrete (EMC), is also proposed to benefit reinforced concrete structures suffering from chloride-induced corrosion.
SARS-CoV-2: Micronutrient Optimization in Supporting Host Immunocompetence (2020)

The novel 2019 coronavirus (SARS-CoV-2) has become an international pandemic.The lack of targeted treatment for SARS-CoV-2 has necessitated the need to evaluate all potential modalities to enhance host immune response.This article reviews the role essential micronutrients play in the risk reduction and treatment of COVID-19.While literature supporting the risk and severity reduction of COVID-19 infections through exogenous supplementation is limited, micronutrient optimization is essential in maintaining host immunocompetence, and deficits may critically impair host defense.The immune supportive mechanisms and physiologic effects of various micronutrients are multifaceted, including the reduction of viral replication, inhibition of polymerase function, augmentation of innate and acquired immune responses, enhancement of anti-inflammatory immune responses, and the reduction of pro-inflammatory responses.
ELECTRON MICROSCOPIC FEATURES OF MULTIPLE SCLEROSIS LESIONS (1965)

SCOPUS: ar.j
An Overview of Campus Recruitment and Selection Procedures and Strategies of Top-10 Business Schools in India (2018)

The research has been carried out in a highly structured and organised manner. It has been designed in such a way to give an overview of the top 10 business schools of India focusing on their campus recruitment and selection procedure. The main objective of this study attempts to reveal the methods and processes involved in the campus placements of the top ten schools and how the organisations act as recruiters there. Thus, few organisations were also approached in order to get a clear idea about the desired questions. A qualitative methodology has been used throughout the study which aimed at reviewing the whole course of actions involved in the establishment of campus placement programs at the institutes and the organisations visiting them. The interviews gave a direct significance to the research and add value to address the issues concerned.
High‐current AlInN/GaN field effect transistors (2005)

Abstract We present a study on AlInN/GaN field effect transistors (FETs) grown by metalorganic chemical vapor phase epitaxy. AlInN can be grown lattice‐matched to GaN with an In concentration of 18%. In this study samples with In concentrations ranging from 9.5 to 24%, covering a range from tensely to compressively strained AlInN layers, were grown on GaN layers on Si(111). From Hall effect and capacitance‐voltage measurements we find high sheet carrier densities for most of the samples indicating a high electron density at the AlInN/GaN heterointerface. This is also reflected in the behavior of processed FETs. Nearly lattice‐matched structures show sheet carrier densities of 3.2 × 10 13 cm –2 and mobilities up to ∼406 cm 2 /Vs. Such Al 0.84 In 0.16 N FETs have maximum DC currents of 1.33 A/mm for devices with 1 µm gate length and 100 µm gate width and an output power of 2.5 W/mm at 2 GHz. The best devices with In concentrations of 19% show maximum output powers of 4.1 W/mm at 2 GHz. In contrast to that a compressively strained AlInN layer with an In concentration of 24% leads to a decreased polarization charge at the heterointerface and a low DC current of ∼70 mA/mm. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Enabling secure location-based services in mobile cloud computing (2013)

The increasing spread of location-based services (LBSs) has led to a renewed research interest in the security of services. To ensure the credibility and availability of LBSs, there is a pressing requirement for addressing access control, authentication and privacy issues of LBSs in a synergistic way. In this paper, we propose an innovative location-based fine-grained access control mechanism for LBSs, enabling effective fine-grained access control, location-based authentication and privacy protection. Our proposed approach is based on the construction of a spatio-temporal predicate-based encryption by means of efficient secure integer comparison. Our experimental results not only validate the effectiveness of our scheme, but also demonstrate that the proposed integer comparison scheme performs better than previous bitwise comparison scheme.
ChemInform Abstract: Synthese von Insekten‐Lockstoffen an Metathesekatalysatoren. (1976)

Abstract Verschiedene Insekten‐Sexuallockstoffe, die für Zwecke der Schädlingsbekämpfung wegen der zu erzielenden Wirkungs‐Selektivität und minimalen Umweltbelastung von erheblicher Bedeutung sind, können anstatt durch bekannte vielstufige Synthesen durch Metathese‐Reaktionen mit billigen petrochemischen Ausgangsmaterialien gewonnen werden.
Automatic Defect Identification of Eddy Current Pulsed Thermography Using Single Channel Blind Source Separation (2014)

Eddy current pulsed thermography (ECPT) is an emerging nondestructive testing and evaluation (NDT&E) technique and has been applied for a wide range of conductive materials. In this paper, a single-channel blind source separation is proposed to process the ECPT image sequences. The proposed method enables: 1) automatically extract valuable spatial and time patterns according to the whole transient response behavior without any training knowledge, 2) automatically identify defect patterns and quantify the defects, and 3) to provide guidelines of choosing the optimal contrast functions that can improve the separation results. In this paper, both mathematical and physical models are discussed and linked. The basis of the selection of separated spatial and time patterns is also presented. In addition, an artificial slot and a thermal fatigue natural crack are applied to validate the proposed method.
Coproporphyrin in urine of newborns with meconium aspiration syndrome. (1983)

We evaluated coproporphyrin in the first urine passed by newborn infants with and without meconium aspiration, by spectrophotometric analysis and thin-layer and "high-performance" liquid chromatography. Urines of newborn infants without meconium aspiration contained only very small quantities of coproporphyrin, detected, after partial purification, by "high-performance" liquid chromatography. Urines of newborn infants with meconium aspiration contained large quantities of coproporphyrin, identified by all three techniques. Urinary coproporphyrin as measured spectrophotometrically correlates well with the "urinary meconium index," and the method is simple, rapid, and reliable, even for samples containing hemoglobin.
The Polypeptide Structure of Transmissible Gastroenteritis Virus (1975)

The polypeptides of purified preparations of the coronavirus responsible for transmissible gastroenteritis of pigs have beem examined by polyacrylamide gel electrophoresis. Four major polypeptides, VPI (mol. wt. 200000), VP2 (50 000), VP3 (30000) and VP4 (28500) and two minor polypeptides, VPIa (105000) and VPIb (80500) have been reproducibly demonstrated in the virion, of which VPI, VP3 and VP4 contain carbohydrate. Treatment of the virion with the proteolytic enzyme bromelain removes the surface projections and VPI, thus identifying this glycopolypeptide as the major structural component of the projection.
Analysis of 16-APSK modulation in AWGN and Rayleigh fading channel (1992)

The error probability for fully differential 16-APSK in a Rayleigh fading channel has been evaluated theoretically and through the use of extensive computer simulation. The optimum ring ratio and detection thresholds have been determined and the results indicate that 16-APSK can be considered as a potential candidate for spectrally efficient digital transmission over practical mobile fading channels.
Field trial of a dual device user experience for iTV (2011)

With the rise in highly capable, mobile and networked secondary devices, the two-screen Enhanced TV is a more plausible proposition today than ever before. This paper presents a field trial of a prototype that aimed to understand a conceptual merger of TV and second screen user experiences. Our prototype concept can be described as a companion device experience that enhances TV viewing by providing auxiliary information and media on a second screen. The additional media is semantically related and synchronized, in terms of timeline, to the TV content. We ran a three-week field trial in 11 households. Participants used our prototype as a companion to their TV shows. We provided a total of 43 episodes from 10 popular TV shows throughout the study period. Overall feedback to our concept was quite positive. 10 out of our 11 participants said they enjoyed the experience. Our prototype allowed participants to better connect with their TV shows and have an enriched social life around TV. We also report some of the discovered user desires regarding user interaction design such as kinds of customization controls needed and the pacing of posts of additional information to the second screen.
Rationale utilization of phospholipid excipients: a distinctive tool for progressing state of the art in research of emerging drug carriers (2022)

Phospholipids have a high degree of biocompatibility and are deemed ideal pharmaceutical excipients in the development of lipid-based drug delivery systems, because of their unique features (permeation, solubility enhancer, emulsion stabilizer, micelle forming agent, and the key excipients in solid dispersions) they can be used in a variety of pharmaceutical drug delivery systems, such as liposomes, phytosomes, solid lipid nanoparticles, etc. The primary usage of phospholipids in a colloidal pharmaceutical formulation is to enhance the drug's bioavailability with low aqueous solubility [i.e. Biopharmaceutical Classification System (BCS) Class II drugs], Membrane penetration (i.e. BCS Class III drugs), drug uptake and release enhancement or modification, protection of sensitive active pharmaceutical ingredients (APIs) from gastrointestinal degradation, a decrease of gastrointestinal adverse effects, and even masking of the bitter taste of orally delivered drugs are other uses. Phospholipid-based colloidal drug products can be tailored to address a wide variety of product requirements, including administration methods, cost, product stability, toxicity, and efficacy. Such formulations that are also a cost-effective method for developing medications for topical, oral, pulmonary, or parenteral administration. The originality of this review work is that we comprehensively evaluated the unique properties and special aspects of phospholipids and summarized how the individual phospholipids can be utilized in various types of lipid-based drug delivery systems, as well as listing newly marketed lipid-based products, patents, and continuing clinical trials of phospholipid-based therapeutic products. This review would be helpful for researchers responsible for formulation development and research into novel colloidal phospholipid-based drug delivery systems.
Modulation of Sub-RPE Deposits In Vitro: A Potential Model for Age-Related Macular Degeneration (2004)

Sub-RPE deposits formed in vitro share ultrastructural features with those seen in vivo. Deposit formation can be modulated by challenge with retinal homogenate, TNF-alpha, or MMP-2. Significantly, the results provide proof of the principle that sub-RPE deposits can be formed and modified in vitro.
Post COVID-19 youth work: A contribution to the Swedish social pedagogical debate (2020)

The coronavirus pandemic affects the whole world. This situation is a very challenging time for all humanity and social services no less. The present article explores how care and different forms of support can or should be offered to young people in the post-COVID-19 youth work. The objective of this paper is to reflect on how social work practitioners can adapt their daily clinical practice by focusing their interventions on the social pedagogical dimensions of social work. The article presents a generalised discussion of practice logics in social work and social pedagogy. Because of the meanings derived from knowledge on the importance of relationships between the helper and the help receiver, social practices in the post-COVID-19 world need to consider social pedagogical expertise in social work practice and the development of preventive assistance for young populations. This effort has been prepared as a part of the project “Social Professionals for Youth Education in the context of European Solidarity".
Superconducting-Insulating Transition in Two-Dimensional<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi mathvariant="italic">a</mml:mi></mml:math>-MoGe Thin Films (1995)

A zero-temperature magnetic-field-tuned superconducting-insulating transition is observed in two-dimensional $a$-MoGe films. The low temperature transport properties of these films show scaling behavior consistent with a transition driven by long-range Coulomb interactions and quantum phase fluctuations in a two-dimensional superconductor. However, contrary to the theoretical predictions we find the critical resistance to be sample dependent. We suggest that the apparent lack of universality in the critical resistance is due to the finite contribution of fermionic excitations to the resistance.
Reconstructing surfaces by volumetric regularization using radial basis functions (2002)

We present a new method of surface reconstruction that generates smooth and seamless models from sparse, noisy, nonuniform, and low resolution range data. Data acquisition techniques from computer vision, such as stereo range images and space carving, produce 3D point sets that are imprecise and nonuniform when compared to laser or optical range scanners. Traditional reconstruction algorithms designed for dense and precise data do not produce smooth reconstructions when applied to vision-based data sets. Our method constructs a 3D implicit surface, formulated as a sum of weighted radial basis functions. We achieve three primary advantages over existing algorithms: (1) the implicit functions we construct estimate the surface well in regions where there is little data, (2) the reconstructed surface is insensitive to noise in data acquisition because we can allow the surface to approximate, rather than exactly interpolate, the data, and (3) the reconstructed surface is locally detailed, yet globally smooth, because we use radial basis functions that achieve multiple orders of smoothness.
Comparing Respiratory Monitoring Performance of Commercial Wireless Devices (2018)

This paper addresses the performance of systems which use commercial wireless devices to make bistatic RF channel measurements for non-contact respiration sensing. Published research has typically presented results from short controlled experiments on one system. In this paper, we deploy an extensive real-world comparative human subject study. We observe twenty patients during their overnight sleep (a total of 160 hours), during which contact sensors record ground-truth breathing data, patient position is recorded, and four different RF breathing monitoring systems simultaneously record measurements. We evaluate published methods and algorithms. We find that WiFi channel state information measurements provide the most robust respiratory rate estimates of the four RF systems tested. However, all four RF systems have periods during which RF-based breathing estimates are not reliable.