gebhart/patrepeval huggingface dataset:
Genetic Determinants of Volatile-Thiol Release by<i>Saccharomyces cerevisiae</i>during Wine Fermentation (2005)

Volatile thiols, particularly 4-mercapto-4-methylpentan-2-one (4MMP), make an important contribution to the aroma of wine. During wine fermentation, Saccharomyces cerevisiae mediates the cleavage of a nonvolatile cysteinylated precursor in grape juice (Cys-4MMP) to release the volatile thiol 4MMP. Carbon-sulfur lyases are anticipated to be involved in this reaction. To establish the mechanism of 4MMP release and to develop strains that modulate its release, the effect of deleting genes encoding putative yeast carbon-sulfur lyases on the cleavage of Cys-4MMP was tested. The results led to the identification of four genes that influence the release of the volatile thiol 4MMP in a laboratory strain, indicating that the mechanism of release involves multiple genes. Deletion of the same genes from a homozygous derivative of the commercial wine yeast VL3 confirmed the importance of these genes in affecting 4MMP release. A strain deleted in a putative carbon-sulfur lyase gene, YAL012W, produced a second sulfur compound at significantly higher concentrations than those produced by the wild-type strain. Using mass spectrometry, this compound was identified as 2-methyltetrathiophen-3-one (MTHT), which was previously shown to contribute to wine aroma but was of unknown biosynthetic origin. The formation of MTHT in YAL012W deletion strains indicates a yeast biosynthetic origin of MTHT. The results demonstrate that the mechanism of synthesis of yeast-derived wine aroma components, even those present in small concentrations, can be investigated using genetic screens.
Strongly Interacting Rydberg Excitations of a Cold Atomic Gas (2012)

Highly excited Rydberg atoms have many exaggerated properties. In particular, the interaction strength between such atoms can be varied over an enormous range. In a mesoscopic ensemble, such strong, long-range interactions can be used for fast preparation of desired many-particle states. We generated Rydberg excitations in an ultra-cold atomic gas and subsequently converted them into light. As the principal quantum number n was increased beyond ~70, no more than a single excitation was retrieved from the entire mesoscopic ensemble of atoms. These results hold promise for studies of dynamics and disorder in many-body systems with tunable interactions and for scalable quantum information networks.
Catalytically Important Residues of E6AP Ubiquitin Ligase Identified Using Acid-Cleavable Photo-Cross-Linkers (2015)

Inactivation of the E6AP E3 ubiquitin ligase (UBE3A gene) causes Angelman syndrome, while aberrant degradation of p53 by E6AP is implicated in cervical cancers. Herein, we describe the development of photo-cross-linkers to discover catalytic residues of E6AP. Using these cross-linkers, we identified covalent modifications of the E6AP catalytic cysteine and two lysines: Lys(847) and Lys(799). Lys(847) is required for the formation of Lys(48)-linked polyubiquitin chains, while the K799A E6AP mutant was more active at producing Lys(48)-linked polyubiquitin chains. Thus, opposing roles of Lys(799) and Lys(847) pave the path forward to pharmacological inhibitors or activators of E6AP for therapeutic purposes.
Gene Transduction and Cell Entry Pathway of Fiber-Modified Adenovirus Type 5 Vectors Carrying Novel Endocytic Peptide Ligands Selected on Human Tracheal Glandular Cells (2004)

Monolayers of cystic fibrosis transmembrane conductance regulator (CFTR)-deficient human tracheal glandular cells (CF-KM4) were subjected to phage biopanning, and cell-internalized phages were isolated and sequenced, in order to identify CF-KM4-specific peptide ligands that would confer upon adenovirus type 5 (Ad5) vector a novel cell target specificity and/or higher efficiency of gene delivery into airway cells of patients with cystic fibrosis (CF). Three different ligands, corresponding to prototypes of the most represented families of phagotopes recovered from intracellular phages, were designed and individually inserted into Ad5-green fluorescent protein (GFP) (AdGFP) vectors at the extremities of short fiber shafts (seven repeats [R7]) terminated by scissile knobs. Only one vector, carrying the decapeptide GHPRQMSHVY (abbreviated as QM10), showed an enhanced gene transduction of CF-KM4 cells compared to control nonliganded vector with fibers of the same length (AdGFP-R7-knob). The enhancement in gene transfer efficiency was not specific to CF-KM4 cells but was observed in other mammalian cell lines tested. The QM10-liganded vector was referred to as AdGFP-QM10-knob in its knobbed version and as AdGFP-QM10 in its proteolytically deknobbed version. AdGFP-QM10 was found to transduce cells with a higher efficiency than its knob-bearing version, AdGFP-QM10-knob. Consistent with this, competition experiments indicated that the presence of knob domains was not an absolute requirement for cell attachment of the QM10-liganded vector and that the knobless AdGFP-QM10 used alternative cell-binding domains on its capsid, including penton base capsomer, via a site(s) different from its RGD motifs. The QM10-mediated effect on gene transduction seemed to take place at the step of endocytosis in both quantitative and qualitative manners. Virions of AdGFP-QM10 were endocytosed in higher numbers than virions of the control vector and were directed to a compartment different from the early endosomes targeted by members of species C Ad. AdGFP-QM10 was found to accumulate in late endosomal and low-pH compartments, suggesting that QM10 acted as an endocytic ligand of the lysosomal pathway. These results validated the concept of detargeting and retargeting Ad vectors via our deknobbing system and redirecting Ad vectors to an alternative endocytic pathway via a peptide ligand inserted in the fiber shaft domain.
Novel System for Decarboxylative Bromination of .ALPHA.,.BETA.-Unsaturated Carboxylic Acids with Diacetoxyiodobenzene (2009)

A simple and mild method for the conversion of varieties of alpha,beta-unsaturated carboxylic acids to the corresponding bromoalkenes using diacetoxyiodobenzene (IBD) in combination with tetraethyl-ammonium bromide (TEAB) at room temperature is discussed. Advantages of this system are short reaction time, easy work up and gave good to excellent yields.
Integrated acousto-optic collinear <i>TE</i> – <i>TM</i> mode convertors for 0.8 μm optical wavelength range (1991)

Low power, narrowband integrated acousto-optic TE–TM mode convenors for the 0.8μm optical wavelength range have been developed. Acoustic drive power of less then 10 mW was required for 96% conversion efficiency. The 0.32 nm optical bandwidth corresponding to the acoustic bandwidth of 138 kHz achieved is the narrowest reported to date for a TE–TM mode convenor.
Gibbs‐ringing artifact removal based on local subvoxel‐shifts (2015)

The robustness of the method suggests it as a suitable candidate for an implementation in the standard image processing pipeline in clinical routine. Magn Reson Med 76:1574-1581, 2016. © 2015 International Society for Magnetic Resonance in Medicine.
Fine directional de-interlacing algorithm using modified Sobel edge detection (2007)

In this paper we propose a fine directional de-interlacing algorithm, based on detection of an accurate edge direction using modified Sobel operation. Existing de-interlacing algorithms determine the presence of edge in pixel resolution or half pixel resolution, so that they can be highly sensitive to noise and lead to image degradation. Therefore the proposed method first considers rough edge tendency, and then through the modified Sobel edge detection it is adaptively adjusted to elucidate fine edge direction using its tendency. Finally, proposed fine directional de-interlacing algorithm yields accurate results compared with other edge-directed de-interlacing algorithms. Experimental results show that the proposed algorithm performs well with a variety of still images compared with conventional intra field de-interlacing algorithms in the literature.
Resonance Raman studies of oriented chromophores: Metmyoglobin single crystals (1989)

We report Soret enhanced resonance Raman studies of single crystals of metmyoglobin. Differing scattering intensities of the 345 cm−1 mode in solution and crystalline forms of the protein indicate a structural perturbation of the heme upon crystallization, possibly involving a propionate substituent of the heme. The immobilization of the heme in the crystal also allows observation of low-quantum-yield photoreduction of the heme that appears to be driven by Soret band absorption. We present experimental investigations of the orientational dependence of the intensity and polarization of several strong heme Raman modes along with calculations that explore the effects of vibrational mode symmetry and of differential coupling to x-, y-, and z-polarized electronic transitions. Orientation studies provide evidence that the vinyl C=C stretching band at 1622 cm−1 is a superposition of two independent modes that couple selectively to the x- and y-polarized Soret transitions. We also demonstrate how modes of nominal B1g and B2g symmetry can be distinguished by crystal studies. Modes that couple preferentially to charge transfer transitions polarized perpendicular to the heme plane are shown to be easily distinguishable from the majority of heme modes, which couple to the in-plane polarized Soret transition; we observe no modes of the former type in metmyoglobin. Finally, we present calculations showing that single-crystal polarization studies of resonance Raman scattering as a function of excitation frequency should be sensitive to the splitting of the nearly xy-degenerate Soret band as well as to the orientation of the x- and y-polarized transitions.
Array BP-XOR codes for reliable cloud storage systems (2013)

Low Density Parity Check (LDPC) codes such as LT codes have received significant attention from both academics and industry in the past few years. By employing the underlying ideas of efficient Belief Propagation (BP) decoding process in LT codes, this paper introduces array BP-XOR codes and shows the equivalence between the edge-colored graph model and degree-one-and-two encoding symbol based array BP-XOR codes. Using this equivalence result, novel [n, n-2] and [n, 2] MDS array BP-XOR codes are designed in this paper.
Intercavity coupling gap width dependence in coupled-cavity lasers (1984)

The width of the intercavity coupling gap between the sections of a coupled-cavity laser is important in determining laser performance. The effects of the gap width on spurious mode suppression, threshold currents, differential quantum efficiency and optimum ratios of drive currents are measured experimentally and compared with theoretical predictions.
Inducing Protein Degradation as a Therapeutic Strategy (2017)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTInducing Protein Degradation as a Therapeutic StrategyCraig M. CrewsCite this: J. Med. Chem. 2018, 61, 2, 403–404Publication Date (Web):November 22, 2017Publication History Published online22 November 2017Published inissue 25 January 2018https://doi.org/10.1021/acs.jmedchem.7b01333Copyright © 2017 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views10239Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (178 KB) Get e-AlertsSUBJECTS:Degradation,Molecules,Receptors,Targeting,Therapeutics Get e-Alerts
Adaptive Color Constancy Using Faces (2014)

In this work we design an adaptive color constancy algorithm that, exploiting the skin regions found in faces, is able to estimate and correct the scene illumination. The algorithm automatically switches from global to spatially varying color correction on the basis of the illuminant estimations on the different faces detected in the image. An extensive comparison with both global and local color constancy algorithms is carried out to validate the effectiveness of the proposed algorithm in terms of both statistical and perceptual significance on a large heterogeneous data set of RAW images containing faces.
Spin Waves and Transport Properties in Ferromagnetic Co–Al–O and Fe–Al–O Granular Films: A Brillouin Scattering Study (2008)

A systematic Brillouin light scattering (BLS) study on long-wavelength spin waves (SWs) in ferromagnetic TM–Al–O (TM=Co, Fe) nano-granular films with thickness of >1 µm was performed under magnetic fields of up to 4 kOe at room temperature. BLS spectra consist of a pair of bulk SW peaks on both frequency sides and a surface localized SW peak only on the positive frequency side in this study. These SW frequencies as a function of the magnetic field can be fully reproduced by the magnetostatic frequency formula developed for a semi-infinite uniform ferromagnetic medium with an exchange coupling and an in-plane uniaxial magnetic anisotropy. We determined a set of the magnetic constants including the exchange field H E for each film. Combining the exchange field H E with the electrical resistivity ρ for each film at room temperature, we found an inverse-square law given by ρ= a ( H E ) -2 for both the Co and Fe granular films with a Fe =30.3 µΩ·cm·(kOe) 2 and a Co =22.1 µΩ·cm·(kOe) 2 , respectively.
Very-large-mode-area, single-mode multicore fiber (2009)

A single-mode evanescently coupled multicore fiber consisting of 19 hexagonally arranged cores is investigated. Theoretical and experimental results are presented and compared to an equivalent hypothetical step-index fiber. A fundamental mode with an effective area of 465 microm(2) and a beam propagation factor M(2) of 1.02 was measured, showing the high potential of the developed fiber.
Illuminating the mixed reality stage: applying complex lighting conditions to AR (2002)

The Mixed Reality Stage is an augmented reality environment which aims to support creative and collaborative stage design processes. In this application scenario, the proper simulation of real lighting is crucial for a seamless integration of virtual objects into a physical model stage. The authors present their approach to emulating complex real world lighting conditions for rendering in real-time. They introduce mechanisms that significantly reduce the effective number of light sources, while simultaneously minimizing the loss of visualization quality.
Design and Characterization of an Injectable Pericardial Matrix Gel: A Potentially Autologous Scaffold for Cardiac Tissue Engineering (2010)

Following ischemic injury in the heart, little to no repair occurs, causing a progressive degeneration of cardiac function that leads to congestive heart failure. Cardiac tissue engineering strategies have focused on designing a variety of injectable scaffolds that range in composition from single-component materials to complex extracellular matrix (ECM)-derived materials. In this study, the pericardial ECM, a commonly used biomaterial, was investigated for use as an injectable scaffold for cardiac repair. It was determined that a solubilized form of decellularized porcine pericardium could be injected and induced to gel in vivo, prompting investigation with human pericardium, which has the decided advantage of offering an autologous therapy. Characterization showed that the matrix gels retained components of the native pericardial ECM, with extant protein and glycosaminoglycan content identified. The results of an in vitro migration assay indicate that the porcine pericardial matrix is a stronger chemoattractant for relevant cell types, but in vivo results showed that the two materials caused statistically similar amounts of neovascularization, demonstrating feasibility as injectable treatments. Potential stem cell mobilization was supported by the presence of c-Kit+ cells within the matrix injection regions. With this work, the pericardium is identified as a novel source for an autologous scaffold for treating myocardial infarction.
A New Type of the Motor-Driven Blood Pump for Artificial Heart (1990)

Technical Briefs A New Type of the Motor-Driven Blood Pump for Artificial Heart Gill J. Cheon, Gill J. Cheon Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, Korea Search for other works by this author on: This Site PubMed Google Scholar Hee C. Kim, Hee C. Kim Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, Korea Search for other works by this author on: This Site PubMed Google Scholar Byoung G. Min, Byoung G. Min Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, Korea Search for other works by this author on: This Site PubMed Google Scholar Dong C. Han Dong C. Han Department of Mechanical Design and Production Engineering, College of Engineering, Seoul National University, Seoul, Korea Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information Gill J. Cheon Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, Korea Hee C. Kim Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, Korea Byoung G. Min Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, Korea Dong C. Han Department of Mechanical Design and Production Engineering, College of Engineering, Seoul National University, Seoul, Korea J Biomech Eng. Nov 1990, 112(4): 473-475 (3 pages) https://doi.org/10.1115/1.2891213 Published Online: November 1, 1990 Article history Received: July 20, 1989 Revised: May 25, 1990 Online: March 17, 2008
The Geoscience Laser Altimeter System (GLAS) Laser Transmitter (2007)

The Geoscience Laser Altimeter System (GLAS), launched in January 2003, is a laser altimeter and lidar for the Earth Observing System's (EOS) ICESat mission. GLAS accommodates three, sequentially operated, diode-pumped, solid-state, Nd:YAG laser transmitters. The laser transmitter requirements, design, and qualification test results for this space-based remote-sensing instrument is summarized and presented.
Zinc(<scp>II</scp>)‐Selective Ratiometric Fluorescent Sensors Based on Inhibition of Excited‐State Intramolecular Proton Transfer (2004)

To develop a zinc(II)-selective emission ratiometric probe suitable for biological applications, we explored the cation-induced inhibition of excited-state intramolecular proton transfer (ESIPT) with a series of 2-(2'-benzenesulfonamidophenyl)benzimidazole derivatives. In the absence of Zn(II) at neutral pH, the fluorophores undergo ESIPT to yield a highly Stokes' shifted emission from the proton-transfer tautomer. Coordination of Zn(II) inhibits the ESIPT process and yields a significant hypsochromic shift of the fluorescence emission maximum. Whereas the paramagnetic metal cations Cu(II), Fe(II), Ni(II), Co(II), and Mn(II) result in fluorescence quenching, the emission response is not altered by millimolar concentrations of Ca(II) or Mg(II), rendering the sensors selective for Zn(II) among all biologically important metal cations. Due to the modular architecture of the fluorophore, the Zn(II) binding affinity can be readily tuned by implementing simple structural modifications. The synthesized probes are suitable to gauge free Zn(II) concentrations in the micromolar to picomolar range under physiological conditions.
Tandem-pumped ytterbium-doped aluminosilicate fiber amplifier with low quantum defect (2012)

We show theoretically that a quantum-defect below 1% is possible in tandem-pumped Yb-doped aluminosilicate fibers operating off the gain peak. Experimentally, we reach a quantum defect of 2% and a slope efficiency of 90% or more.
The Magnetic Susceptibilities of Some Aromatic Hydrocarbon Anions<sup>1a,b</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Magnetic Susceptibilities of Some Aromatic Hydrocarbon Anions1a,bTing Li Chu and Shan Chi YuCite this: J. Am. Chem. Soc. 1954, 76, 13, 3367–3369Publication Date (Print):July 1, 1954Publication History Published online1 May 2002Published inissue 1 July 1954https://pubs.acs.org/doi/10.1021/ja01642a004https://doi.org/10.1021/ja01642a004research-articleACS PublicationsRequest reuse permissionsArticle Views650Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts