gebhart/patrepeval huggingface dataset:
α<sub>2</sub>‐ADRENOCEPTORS MEDIATE CLONIDINE‐INDUCED SEDATION IN THE RAT (1979)

The central α‐adrenoceptors responsible for mediating clonidine‐induced sedation in rats have been characterized according to their sensitivity to α‐adrenoceptor agonists and antagonists. Clonidine, injected intraperitoneally or intracerebroventricularly, caused dose‐dependent sedation, both in terms of a reduction in the time that rats could remain on an accelerating rotarod and in terms of overt sedation assessed visually. Following intracerebroventricular injection, xylazine, naphazoline and methoxamine, but not phenylephrine, produced similar effects. The sedation caused by intraperitoneal injection of clonidine was antagonized by intracerebroventricularly injected phentolamine, yohimbine, piperoxan and tolazoline but not by labetalol, thymoxamine or prazosin. The relative potencies of the agonists in causing sedation and of the antagonists in inhibiting the sedative effect of clonidine clearly demonstrated that the central α‐adrenoceptors mediating clonidine‐induced sedation are the same as the peripheral presynaptic α 2 ‐adrenoceptors. All the α‐adrenoceptor agonists caused hypothermia after intracerebroventricular injection, but their order of potency was different from that in producing sedation. The hypothermic effect of intraperitoneally injected clonidine was little affected by any of the antagonists administered intracerebroventricularly. No conclusions could be drawn concerning the type of receptor responsible for mediating hypothermia.
Oxidation of mandelic acid by Fenton's reagent (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of mandelic acid by Fenton's reagentCheves Walling and Kalyani AmarnathCite this: J. Am. Chem. Soc. 1982, 104, 5, 1185–1189Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/ja00369a005https://doi.org/10.1021/ja00369a005research-articleACS PublicationsRequest reuse permissionsArticle Views839Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lignins as agents for bio-protection of wood (2011)

Abstract Pinewood was modified by vacuum impregnation with various aqueous lignin solutions of low concentration (0.5– 1.0%) and its decay resistance was tested by the standard procedure EN 113. Five lignin types were tested against three brown rot and one white rot fungi. The bio-durability of wood was considerably increased by the treatment. The highest effect of modification was for alkali, kraft, hydrolysis lignins and industrial lignosulfonate, when mass losses of wood for brown-rot fungi were negligible. The effect of the modification with certified lignosulfonates was insignificant. Chemical analysis revealed that phenols, which are leached from lignin and are adsorbed by wood in the impregnation process, could act as a biocide. The hydrophilic properties of wood either did not change (certified lignins) or were enhanced because of some change in the pore structure (industrial lignins). Further tests are needed to verify the positive effects of this technologically simple and environmentally friendly treatment.
Inducing Photonic Transitions between Discrete Modes in a Silicon Optical Microcavity (2008)

We show the existence of direct photonic transitions between modes of a silicon optical microcavity spaced apart in wavelength by over 8 nm. This is achieved by using ultrafast tuning of the refractive index of the cavity over a time interval that is comparable to the inverse of the frequency separation of modes. The demonstrated frequency mixing effect, i.e., the transitions between the modes, would enable on-chip silicon comb sources which can find wide applications in optical sensing, precise spectroscopy, and wavelength-division multiplexing for optical communications and interconnects.
Heavy Element Spectra (1949)

Because spectrochemical analysis has proved useful in establishing the purity of very small samples of the new heavy elements as they were produced in turn by the Plutonium Project, photographs of the spectra of these elements have accumulated.
A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas (2014)

Pediatric glioblastomas (GBM) are highly aggressive and lethal tumors. Recent sequencing studies have shown that ~30 % of pediatric GBM and ~80 % of diffuse intrinsic pontine gliomas show K27M mutations in the H3F3A gene, a variant encoding histone H3.3. H3F3A K27M mutations lead to global reduction in H3K27me3. Our goal was to develop biomarkers for the histopathologic detection of these tumors. Therefore, we evaluated the utility of measuring H3K27me3 global reduction as a histopathologic and prognostic biomarker and tested an antibody directed specifically against the H3.3 K27M mutation in 290 samples. The study cohort included 203 pediatric (including 38 pediatric high-grade astrocytomas) and 38 adult brain tumors of various subtypes and grades and 49 non-neoplastic reactive brain tissues. Detection of H3.3 K27M by immunohistochemistry showed 100 % sensitivity and specificity and was superior to global reduction in H3K27me3 as a biomarker in diagnosing H3F3A K27M mutations. Moreover, cases that stained positive for H3.3 K27M showed a significantly poor prognosis compared to corresponding negative tumors. These results suggest that immunohistochemical detection of H3.3 K27M is a sensitive and specific surrogate for the H3F3A K27M mutation and defines a prognostically poor subset of pediatric GBM.
Performance of the burst-level ARQ error protection scheme in an indoor mobile radio environment (2002)

Burst-level ARQ, a new error protection scheme for speech transmission, is based on ARE (automatic repeat request) which is used on burst level, i.e., only the erroneous bursts are repeated. It is more flexible than a conventional error protection based on forward error correction (FEC) because the redundancy is sent only when required. Furthermore, with a limited number of retransmissions, it provides a low delay. The performance of the burst-level ARQ is studied by computer simulations in an indoor environment and compared with conventional FEC schemes using convolutional codes and interleaving. The cellular capacity of both schemes is calculated taking into account the required carrier capacity (i.e., the number of slots per TDMA frame) as web as the frequency reuse efficiency (i.e., the robustness to co-channel interference). The burst level ARQ is shown to be a good solution when low delay and high performance is required.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Solidification of Sludges with Portland Cement (1970)

Raw primary sewage sludge and a chicken manure was solidified by mixing with fly ash and Portland cement. By varying the proportions of sludge solids, fly ash, and cement in a mix, it was possible to control the time required for final set, and the physical properties of the resulting solid matrix. A maximum of 3.3% of the input phosphate was leached from the matrices over a 15-day period. Phosphates are efficiently incorporated into the solid matrix.
Within-chip variability analysis (2002)

Current, integrated circuits are large enough that device and interconnect parameter variations within it chip are as important as those same variations from chip to chip. Previously, digital designers were concerned only with chip-to-chip variability, for which analysis techniques exist; concern for within-chip variations has been in the domain of analog circuit design. In this paper, we lay the groundwork needed to analyze the impact of inter-chip variations on digital circuits and propose an extreme-case analysis algorithm to efficiently determine the worst case performance due to such variability.
PEFC Cathode Alloy Catalysts Prepared by a Novel Process Using a Chelating Agent (2002)

A new Fe-Pt alloy catalyst for the oxygen reduction reaction of PEMFCs was prepared using a chelating agent, EDTA-Fe(III), as its non-precious metal source. Characterization showed that while the conventional catalyst showed particle aggregation over 5 nm, the new catalyst had a uniform particle size and a larger surface area. This new catalyst showed a higher catalytic mass activity than a conventional alloy catalyst although the specific activities are in the same range.
Synthesis and Characterization of <i>trans</i>-2-Aminocyclohexanecarboxylic Acid Oligomers:  An Unnatural Helical Secondary Structure and Implications for β-Peptide Tertiary Structure (1999)

The preparation, crystal structures, and circular dichroism (CD) spectra of two oligomers of optically active trans-2-aminocyclohexanecarboxylic acid are reported. In the solid state, both the tetramer and the hexamer of this β-amino acid display a helical conformation that involves 14-membered-ring hydrogen bonds between a carbonyl oxygen and the amide proton of the second residue toward the N-terminus. (For comparison, the familiar α-helix observed in conventional peptides is associated with a 13-membered-ring hydrogen bond between a carbonyl oxygen and the amide proton of the fourth residue toward the C-terminus.) These crystallographic data, along with CD data obtained in methanol, suggest that the 14-helix constitutes a stable secondary structure for β-amino acid oligomers (“β-peptides”). In addition, the crystal packing pattern observed for the hexamer offers a blueprint for the design of β-peptides that might adopt a helical bundle tertiary structure.
CLINICAL AND HISTOPATHOLOGIC FINDINGS AFTER PHOTODYNAMIC THERAPY OF CHOROIDAL MELANOMA (2012)

Photodynamic therapy and bevacizumab can induce closure of the superficial vasculature of a pigmented choroidal melanoma, but in none of our cases, there was evidence of tumor destruction from this treatment. Preoperative PDT may be useful to reduce the potential of bleeding at the time of tumor biopsy. Our cases do not support the use of a single session of PDT as a primary treatment for pigmented small choroidal melanomas.
Immunosuppressive activity of capsaicinoids: capsiate derived from sweet peppers inhibits NF-κB activation and is a potent antiinflammatory compound in vivo (2002)

Capsiate and its dihydroderivatives are the major capsaicinoids of sweet pepper. These new capsaicinoids do not activate the vanilloid receptor type 1 (VR1) but they share with capsaicin (CPS)some biological activities mediated in a VR1-independent fashion. In this study we show that CPS and nordihydrocapsiate (CPT) inhibit early and late events in T cell activation, including CD69, CD25 and ICAM-1 cell surface expression, progression to the S phase of the cell cycle and proliferation in response to TCR and CD28 co-engagement. Moreover, both CPS and CPT inhibit NF-kappaB activation in response to different agents including TNF-alpha. CPS itself does not affect the DNA-binding ability of NF-kappaB but it prevents IkappaB kinase activation and IkappaBalpha degradation in a dose-dependent manner, without inhibiting the activation of the mitogen-activated protein kinases, p38, extracellular regulated kinase and c-Jun N-terminal protein kinase. Moreover, intraperitoneal pretreatment with CPT prevented mice from lethal septic shock induced by lipopolysaccharide. In a second model of inflammation CPT pretreatment greatly reduced the extensive damage in the glandular epithelium observed in the bowel of DSS-treated mice. Taken together, these results suggest that CPT and related synthetic analogues target specific pathways involved in inflammation, and hold considerable potential for dietary health benefits as well as for pharmaceutical development.
Human Adipose Stem Cells (2012)

Adipose-derived stem cells are multipotent cells that can easily be extracted from adipose tissue, are capable of expansion in vitro, and have the capacity to differentiate into multiple cell lineages, which have the potential for use in regenerative medicine. However, several issues need to be studied to determine safe human use. For example, there are questions related to isolation and purification of adipose-derived stem cells, their effect on tumor growth, and the enforcement of U.S. Food and Drug Administration regulations. Numerous studies have been published, with the interest in the potential for regenerative medicine continually growing. Several clinical trials using human adipose stem cell therapy are currently being performed around the world, and there has been a rapid evolution and expansion of their number. The purpose of this article was to review the current published basic science evidence and ongoing clinical trials involving the use of adipose-derived stem cells in plastic surgery and in regenerative medicine in general. The results of the studies and clinical trials using adipose-derived stem cells reported in this review seem to be promising not only in plastic surgery but also in a wide variety of other specialties. Nevertheless, those reported showed disparity in the way adipose-derived stem cells were used. Further basic science experimental studies with standardized protocols and larger randomized trials need to be performed to ensure safety and efficacy of adipose-derived stem cells use in accordance with U.S. Food and Drug Administration guidelines.
Deficits in spatial learning and synaptic plasticity induced by the rapid and competitive broad‐spectrum cyclooxygenase inhibitor ibuprofen are reversed by increasing endogenous brain‐derived neurotrophic factor (2003)

Cyclooxygenase (COX), which is present in two isoforms (COX1 and 2), synthesizes prostaglandins from arachidonic acid; it plays a crucial role in inflammation in both central and peripheral tissues. Here, we describe its role in synaptic plasticity and spatial learning in vivo via an effect on brain-derived neurotrophic factor (BDNF) and prostaglandin E2 (PGE2; both measured by Elisa). We found that broad-spectrum COX inhibition (BSCI) inhibits the induction of long-term potentiation (LTP; the major contemporary model of synaptic plasticity), and causes substantial and sustained deficits in spatial learning in the watermaze. Increases in BDNF and PGE2 following spatial learning and LTP were also blocked. Importantly, 4 days of prior exercise in a running wheel increased endogenous BDNF levels sufficiently to reverse the BSCI of LTP and spatial learning, and restored a parallel increase in LTP and learning-related BDNF and PGE2. In control experiments, we found that BSCI had no effect on baseline synaptic transmission or on the nonhippocampal visible-platform task; there was no evidence of gastric ulceration from BSCI. COX2 is inhibited by glucorticoids; there was no difference in blood corticosterone levels as measured by radioimmunoassay in any condition. Thus, COX plays a previously undescribed, permissive role in synaptic plasticity and spatial learning via a BDNF-associated mechanism.
Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe). (1982)

A toxic protein, viscumin, was isolated from extracts of mistletoe by affinity chromatography on acid-treated Sepharose 4B. Viscumin was selectively bound to the column and could be eluted with lactose. It migrated in polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate corresponding to Mr = 60,000. In addition, two bands migrating corresponding to Mr = 29,000 and 32,000 were found. After treatment with 2-mercaptoethanol, only 2 bands (Mr = 29,000 and 34,000) were found. Apparently, viscumin consists of two chains which, in some of the molecules, are disulfide-linked. Protection experiments with antiserum against viscumin indicated that the major part of the cytotoxic activity in mistletoe extracts is due to viscumin. Gel filtration experiments on Sephacryl 200 indicated that, at low concentrations, viscumin occurs as a monomer and at higher concentrations as a dimer. Viscumin was found to inhibit protein synthesis in cell-free systems. When the two constituent peptide chains of viscumin were eluted from polyacrylamide gels and tested for ability to inhibit cell-free protein synthesis, this property was found to be associated with the fastest migrating chain, here denoted the A chain. The heavier chain was denoted the B chain. The A chain was found to inhibit protein synthesis by inactivating the ribosomes catalytically. Reconstitution experiments with isolated ribosomal subunits from untreated and A chain-treated ribosomes showed that the 60 S ribosomal subunit was selectively inactivated.
Improving the Sensitivity and Dynamic Range of Reagentless Fluorescent Immunosensors by Knowledge-Based Design (2004)

The variable fragment (Fv) of an antibody can be transformed into a reagentless fluorescent biosensor by mutating a residue into a cysteine in the neighborhood of the paratope (antigen-binding site) and then coupling an environment-sensitive fluorophore, e.g., N-((2-(iodoacetoxy)ethyl)-N-methyl)amino-7-nitrobenz-2-oxa-1,3-diazole (IANBD ester), to the mutant cysteine. For some residues, named operational, the formation of the conjugate does not affect the affinity of the Fv fragment for the antigen, and the binding of the antigen generates a measurable variation in the fluorescence intensity of the conjugate. We tested if this signal variation could be increased by coupling several molecules of fluorophores to the same molecule of Fv. Seven operational residues have been previously identified in the single-chain Fv (scFv) of monoclonal antibody D1.3 (mAbD1.3), directed against lysozyme. Ten double mutants of scFvD1.3, involving these residues, were constructed and coupled to the IANBD ester. The fluorescence of the double conjugates revealed a transfer of resonance energy between the two identical fluorescent groups. This homotranfer could be more important in the free state of the conjugate than in its antigen-bound state and increase its sensitivity for the detection of the antigen by up to 2.9-fold. A poorly sensitive conjugate could be improved by coupling a second molecule of fluorophore to residues located far from the paratope. Mutations altering the affinity of scFvD1.3 for lysozyme were introduced into one of its fluorescent conjugates. Using a mixture of three mutant derivatives of this unique conjugate, we could titrate lysozyme with precision in a concentration range encompassing 3 orders of magnitude.
Silicon micromachined SCALED technology (1995)

Silicon micromachining technology will play an important role in the fabrication of high-bandwidth servo controlled microelectromechanical (mechatronic) components for super-compact disk drives. At the University of California, Los Angeles, and the California Institute of Technology, for the last three years, we have initiated a number of industry-supported joint research projects to develop the necessary technology building blocks for an integrated drive design of the future. These efforts include a silicon read/write head microgimbal with integrated electrical and mechanical interconnects, which targets the next-generation 30% form factor pico-sliders, and an electromagnetic piggyback microactuator in super-high-track-density applications, both of which utilize state-of-the-art silicon micromachining fabrication techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A high average-efficiency SiGe HBT power amplifier for WCDMA handset applications (2005)

The linearity of a silicon-germanium (SiGe) HBT power amplifier (PA) is analyzed with the help of a power-dependent coefficient Volterra technique. The effect of emitter inductance is included and the dominant sources of nonlinearity are identified. A dynamic current biasing technique is developed to improve the average power efficiency for wide-band code-division multiple-access (WCDMA) PAs. The average power efficiency is improved by more than a factor of two compared to a typical class-AB operation, while the power gain keeps roughly constant. The measured adjacent channel power ratio with 5and 10-MHz offsets at 23.9-dBm average channel output power are -33 and -58.8 dBc, respectively, and satisfies the Third-generation partnership project WCDMA specifications. The output power at the 1-dB compression point is 25.9 dBm.
Validation of Large Particle Flow Cytometry for the Analysis and Sorting of Intact Pancreatic Islets (2005)

COPAS large particle flow cytometry provides a novel automated approach for quantification of intact islets and determination of islet equivalent yield. In addition, the ability to analyze and sort islets based upon user defined criterion opens unique avenues for experimentation.
How an Inhibitor of the HIV-I Protease Modulates Proteasome Activity (1999)

The human immunodeficiency virus, type I protease inhibitor Ritonavir has been used successfully in AIDS therapy for 4 years. Clinical observations suggested that Ritonavir may exert a direct effect on the immune system unrelated to inhibition of the human immunodeficiency virus, type I protease. In fact, Ritonavir inhibited the major histocompatibility complex class I restricted presentation of several viral antigens at therapeutically relevant concentrations (5 microM). In search of a molecular target we found that Ritonavir inhibited the chymotrypsin-like activity of the proteasome whereas the tryptic activity was enhanced. In this study we kinetically analyzed how Ritonavir modulates proteasome activity and what consequences this has on cellular functions of the proteasome. Ritonavir is a reversible effector of proteasome activity that protected the subunits MB-1 (X) and/or LMP7 from covalent active site modification with the vinyl sulfone inhibitor(125)I-NLVS, suggesting that they are the prime targets for competitive inhibition by Ritonavir. At low concentrations of Ritonavir (5 microM) cells were more sensitive to canavanine but proliferated normally whereas at higher concentrations (50 microM) protein degradation was affected, and the cell cycle was arrested in the G(1)/S phase. Ritonavir thus modulates antigen processing at concentrations at which vital cellular functions of the proteasome are not yet severely impeded. Proteasome modulators may hence qualify as therapeutics for the control of the cytotoxic immune response.
System Analysis and Test Bed for an Air-Breathing Electric Propulsion System (2014)

An air-breathing electric propulsion system (RAM-EP) ingests the air of the residual atmosphere through a mechanical intake and uses it as propellant for an electric thruster. A system analysis is shown within this work to derive the main design drivers for a RAM-EP mission application. The small-scale inductive plasma generator IPG6-S of the University of Stuttgart is continually improved, and is used as a test bed for a RAM-EP system using an IPG source.