gebhart/patrepeval huggingface dataset:
Label-Free Luminescent Mesoporous Silica Nanoparticles for Imaging and Drug Delivery (2013)

We report herein a straightforward and label-free approach to prepare luminescent mesoporous silica nanoparticles. We found that calcination at 400 °C can grant mesoporous organosilica nanoparticles with strong fluorescence of great photo- and chemical stability. The luminescence is found to originate from the carbon dots generated from the calcination, rather than the defects in the silica matrix as was believed previously. The calcination does not impact the particles' abilities to load drugs and conjugate to biomolecules. In a proof-of-concept study, we demonstrated that doxorubicin (Dox) can be efficiently encapsulated into these fluorescent mesoporous silica nanoparticles. After coupled to c(RGDyK), the nanoconjugates can efficiently home to tumors through interactions with integrin αvβ3 overexpressed on the tumor vasculature. This calcination-induced luminescence is expected to find wide applications in silica-based drug delivery, nanoparticle coating, and immunofluorescence imaging.
Evolution of the wall shear stresses during the progressive enlargement of symmetric abdominal aortic aneurysms (2006)

The changes in the evolution of the spatial and temporal distribution of the wall shear stresses (WSS) and gradients of wall shear stresses (GWSS) at different stages of the enlargement of an abdominal aortic aneurysm (AAA) are important in understanding the aetiology and progression of this vascular disease since they affect the wall structural integrity, primarily via the changes induced on the shape, functions and metabolism of the endothelial cells. Particle image velocimetry (PIV) measurements were performed in in vitro aneurysm models, while changing their geometric parameters systematically. It has been shown that, even at the very early stages of the disease, i.e. increase in the diameter $\leq\,$ 50%, the flow separates from the wall and a large vortex ring, usually followed by internal shear layers, is created. These lead to the generation of WSS that drastically differ in mean and fluctuating components from the healthy vessel. Inside the AAA, the mean WSS becomes negative along most of the aneurysmal wall and the magnitude of the WSS can be as low as 26% of the value in a healthy abdominal aorta. Two regions with distinct patterns of WSS were identified inside the AAA: the proximal region of flow detachment, characterized by oscillatory WSS of very low mean, and the region of flow reattachment, located distally, where large, negative WSS and sustained GWSS are produced as a result of the impact of the vortex ring on the wall. Comparison of the measured values of WSS and GWSS to an analytical solution, calculated for slowly expanding aneurysms shows a very good agreement, thus providing a validation of the PIV measurements.
Multihop radio networks in random terrains: Connectivity and some terrain adaptive routing algorithms (2002)

Multihop radio networks have been proposed to provide communication services in environments without suitable infrastructure. In most studies of these networks propagation models dependent only on the distance between transmitter and receiver were used. Also the network is assumed to be connected. In terrains with a lot of obstacles (mountains, forests) however, it might be difficult to obtain a connected network. The connectivity and performance of a ground radio network is investigated for various terrain types, using a more detailed propagation model. It is shown that the r/sup -/spl alpha// model, used in former studies, yields pessimistic results in predicting the network connectivity. In addition, the performance of three terrain adaptive routing algorithms is presented. Simulation results show that both the algorithm that minimizes the number of hops and the algorithm that minimizes the interference have a smaller delay than the minimum maximum path loss algorithm, where the path with the maximum pathloss is minimum compared to other paths.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Alterations in the regulatory region of the human papillomavirus type 6 genome are generated during propagation in Escherichia coli (1988)

We analyzed the long control regions (LCRs) of seven human papillomavirus type 6b (HPV-6b) clones, which contained prototype HPV-6b sequences recloned into various plasmid vectors and propagated in different strains of Escherichia coli. Southern blot analysis and DNA sequencing demonstrated three different sequences, each distinct from the published prototype HPV-6b sequence. Two of the plasmids contained insertions of 24 and 94 base pairs (bp) and a 1-bp deletion. Four plasmids contained insertions of 24 and 58 bp and a deletion of 49 bp. One plasmid contained a single insertion of 77 bp. The 94-, and 58-bp insertions occurred at the same site and had 100% positional identity across their shared lengths. All changes were located in the purine-thymidine-rich region of the LCR (nucleotides 7292 to 7400). Two additional LCR sequences were detected by restriction analysis of two other HPV-6b clones. We conclude that the purine-thymidine-rich region of the LCR is a hot spot for recombination in E. coli and that the alterations are the result of recA-independent events. These results emphasize the need to rigorously prove that a cloned isolate is an authentic copy of the genomic DNA present in the original lesion. In addition, the data indicate that the HPV-6b LCR sequences employed in different laboratories may be different, even if their parental DNAs were identical. Finally, we discuss the need for caution in assigning biological significance to alterations in this region, in view of the limited data available on the true identity of the HPV-6b LCR.
The α <sub>v</sub> β <sub>1</sub> integrin plays a critical in vivo role in tissue fibrosis (2015)

Integrins are transmembrane heterodimeric receptors that contribute to diverse biological functions and play critical roles in many human diseases. Studies using integrin subunit knockout mice and inhibitory antibodies have identified important roles for nearly every integrin heterodimer and led to the development of a number of potentially useful therapeutics. One notable exception is the αvβ1 integrin. αv and β1 subunits are individually present in numerous dimer pairs, making it challenging to infer specific roles for αvβ1 by genetic inactivation of individual subunits, and αvβ1 complex-specific blocking antibodies do not yet exist. We therefore developed a potent and highly specific small-molecule inhibitor of αvβ1 to probe the function of this understudied integrin. We found that αvβ1, which is highly expressed on activated fibroblasts, directly binds to the latency-associated peptide of transforming growth factor-β1 (TGFβ1) and mediates TGFβ1 activation. Therapeutic delivery of this αvβ1 inhibitor attenuated bleomycin-induced pulmonary fibrosis and carbon tetrachloride-induced liver fibrosis, suggesting that drugs based on this lead compound could be broadly useful for treatment of diseases characterized by excessive tissue fibrosis.
Anomalous Power-Usage Behavior Detection from Smart Home Wireless Communications (2019)

With the rapid development of Internet of things (IoT) technologies, smart home systems are getting more and more popular in our daily life. Besides providing convenient functionality and tangible benefits, smart home systems expose users to security risks. In this paper, we proposed SHGuard, an anomaly detection approach based on power usage data exposed from wireless communications in the smart home system. SHGuard monitors and collects the electricity-usage data sent from the smart sockets. Based on the collected data, we developed a method to identify/infer the type of device and formally defined the user behavior pattern according to the device event features, e.g., frequent sequence pattern set, the support degree, the sequence length and the occurrence time of the power changing event. SHGuard extracts and builds the normal behavior pattern during the initialization stage. It continuously infers the smart devices' states by monitoring the electricity usage data and updates the user behavior patterns. Any abnormal behaviors will be detected once the current user behavior pattern deviates from the original pattern. We prototyped our method and evaluated SHGuard using UCI dataset. The experiment results illustrated the efficiency of SHGuard.
Design and Implementation of an Integrated Reconfigurable Silicon Photonics Switch Matrix in IRIS Project (2016)

This paper aims to present the design and the achieved results on a CMOS electronic and photonic integrated device for low cost, low power, transparent, mass-manufacturable optical switching. An unprecedented number of integrated photonic components (more than 1000), each individually electronically controlled, allows for the realization of a transponder aggregator device which interconnects up to eight transponders to a four direction colorless-directionless-contentionless ROADM. Each direction supports 12 200-GHz spaced wavelengths, which can be independently added or dropped from the network. An electronic ASIC, 3-D integrated on top of the photonic chip, controls the switch fabrics to allow a complete and microsecond fast reconfigurability.
Various human hematopoietic growth factors (interleukin-3, GM-CSF, G- CSF) stimulate clonal growth of nonhematopoietic tumor cells [see comments] (1989)

We have studied the effect of recombinant human hematopoietic growth factors (interleukin-3 [rhIL-3], granulocyte-macrophage colony-stimulating factor [rhGM-CSF], and granulocyte CSF [rhG-CSF]) on the clonal growth of human colon adenocarcinoma cell lines HTB-38, CCL 187, and WiDr (CCL 218). The factors stimulated clonal growth of HTB-38 and CCL 187 in a capillary modification of the human tumor clonogenic assay in agar up to twofold. There were dose-response correlations over a range of 1 to 10,000 U/mL for rhIL-3, rhGM-CSF, and rhG-CSF. Incubation with neutralizing monoclonal antibodies abolished the stimulation of clonal growth by rhGM-CSF. The WiDr cell line was nonresponsive to rhIL-3 and rhGM-CSF. These results represent the first evidence that a variety of hematopoietic growth factors can stimulate the growth of clonogenic cells of some nonhematopoietic malignant cell lines in vitro.
The Effect of X-Irradiation on Thymidine Kinase Activity in Synchronous Populations of HeLa Cells (1971)

The periodic synthesis of thymidine kinase during the cell cycle has been studied in synchronous populations of HeLa cells. There is a sharp decrease in enzyme activity after cell division followed by a rise in thymidine kinase levels which reaches a maximum several hours after the peak of DNA synthetic activity. Cells treated with inhibitors of protein or RNA synthesis early in the cycle have low levels of thymidine kinase activity. Cells exposed to irradiation, however, have a pattern of prolonged elevated levels of thymidine kinase activity. This altered pattern of enzyme activity resulting from x-irradiation can be mimicked by treatment of the cells with inhibitors of DNA synthesis or of cell division. The data indicate that radiation of a dose of 2000 rads does not interfere with the synthesis of the enzyme and that the prolonged elevation of thymidine kinase activity in x-irradiated cells reflects interference with the progression of the cell population to a phase of the cell cycle that is detriment...
Similarity search through fuzzy relational algebra (1999)

Multimedia informations systems and Web-based applications such as search engines need to automatically extract and classify multimedia data such as images and textual documents. For this reason, very significant research has focused on similarity queries from the standpoint of the definition and creation of appropriate index structures. We provide a formal framework in which formulate powerful similarity-based queries. For this purposes a fuzzy relational algebra extending the classical relational algebra is defined and equivalence and containment rules for query processing are given.
Glucose-Triggered Drug Delivery from Borate Mediated Layer-by-Layer Self-Assembly (2010)

In this study, we report a novel approach for glucose-triggered anticancer drug delivery from the self-assembly of neutral poly(vinyl alcohol) (PVA) and chitosan. In the present study, we have fabricated multilayer thin film of PVA-borate and chitosan on colloidal particle (MF particle) and monitored the layer-by-layer growth using Zeta potential measurements. Formation of multilayer membrane on MF particle has been further characterized with transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM). Subsequently, disintegration of multilayer thin film and microcapsules was observed in presence of glucose. We investigated the disassembly of PVA-borate and chitosan self-assembly under CLSM and atomic force microscopy. These results suggest that this multilayer thin film is very efficient for encapsulation and release of DOX molecules above certain concentration of glucose (25 mM). This glucose-sensitive self-assembly is relevant for the application of anticancer therapeutic drug delivery.
High-Resolution Enabled 12-Plex DiLeu Isobaric Tags for Quantitative Proteomics (2014)

Multiplex isobaric tags (e.g., tandem mass tags (TMT) and isobaric tags for relative and absolute quantification (iTRAQ)) are a valuable tool for high-throughput mass spectrometry based quantitative proteomics. We have developed our own multiplex isobaric tags, DiLeu, that feature quantitative performance on par with commercial offerings but can be readily synthesized in-house as a cost-effective alternative. In this work, we achieve a 3-fold increase in the multiplexing capacity of the DiLeu reagent without increasing structural complexity by exploiting mass defects that arise from selective incorporation of (13)C, (15)N, and (2)H stable isotopes in the reporter group. The inclusion of eight new reporter isotopologues that differ in mass from the existing four reporters by intervals of 6 mDa yields a 12-plex isobaric set that preserves the synthetic simplicity and quantitative performance of the original implementation. We show that the new reporter variants can be baseline-resolved in high-resolution higher-energy C-trap dissociation (HCD) spectra, and we demonstrate accurate 12-plex quantitation of a DiLeu-labeled Saccharomyces cerevisiae lysate digest via high-resolution nano liquid chromatography-tandem mass spectrometry (nanoLC-MS(2)) analysis on an Orbitrap Elite mass spectrometer.
Effects of Ketamine on Metabolomics of Serum and Urine in Cynomolgus Macaques (Macaca fascicularis). (2016)

In this study, a metabolomics approach based on nuclear magnetic resonance spectroscopy and pertinent multivariate data analyses was used to evaluate the effect of ketamine on metabolic markers in cynomolgus macaques. Principal component analysis and orthogonal projection to latent structure with discriminant analysis showed that ketamine (10 mg/kg) induced metabolic perturbations. Compared with the control group, ketamine-treated macaques had lower serum levels of α-glucose, myoinositol, lactate and succinate and lower urine levels of pyruvate and lactate. In contrast, the levels of leucine in serum and arginine in urine were significantly higher in the ketamine group. Our results also demonstrated that a single injection of ketamine influenced the major energy and amino acid metabolic pathways in cynomolgus macaques. Our study suggests that these influences should be considered in the design of experiments and the interpretation related blood and urine data from ketamine-sedated cynomolgus macaques.
Rationally Designed Pincer‐Type Heck Catalysts Bearing Aminophosphine Substituents: Pd<sup>IV</sup> Intermediates and Palladium Nanoparticles (2008)

The aminophosphine-based pincer complexes [C6H3-2,6-(XP(piperidinyl)2)2Pd(Cl)] (X=NH 1; X=O 2) are readily prepared from cheap starting materials by sequential addition of 1,1',1''-phosphinetriyltripiperidine and 1,3-diaminobenzene or resorcinol to solutions of [Pd(cod)(Cl)2] (cod=cyclooctadiene) in toluene under N2 in "one pot". Compounds 1 and 2 proved to be excellent Heck catalysts and allow the quantitative coupling of several electronically deactivated and sterically hindered aryl bromides with various olefins as coupling partners at 140 degrees C within very short reaction times and low catalyst loadings. Increased reaction temperatures also enable the efficient coupling of olefins with electronically deactivated and sterically hindered aryl chlorides in the presence of only 0.01 mol % of catalyst. The mechanistic studies performed rule out that homogeneous Pd 0 complexes are the catalytically active forms of 1 and 2. On the other hand, the involvement of palladium nanoparticles in the catalytic cycle received strong experimental support. Even though pincer-type Pd IV intermediates derived from 1 (and 2) are not involved in the catalytic cycle of the Heck reaction, their general existence as reactive intermediates (for example, in other reactions) cannot be excluded. On the contrary, they were shown to be thermally accessible. Compounds 1 and 2 show a smooth halide exchange with bromobenzene to yield their bromo derivatives in DMF at 100 degrees C. Experimental observations revealed that the halide exchange most probably proceeded via pincer-type Pd IV intermediates. DFT calculations support this hypothesis and indicated that aminophosphine-based pincer-type Pd IV intermediates are generally to be considered as reactive intermediates in reactions with aryl halides performed at elevated temperatures.
Cloning and expression of human anti-rhG-CSF single chain antibody gene (2005)

Novel human anti-rhG-CSF (anti-recombinant human granulocyte colony stimulate factor) ScFv (single-chain fragment of variable domain) was cloned and expressed from phage display library. The gene of ScFv was cloned into vectors of pCANTAB 5E. By phage displaying, ScFv in form of ScFv-g3p fusion protein was panned based on its binding capacity to the rhG-CSF antigens on the cell surface. By the enzyme-linked immuno-sorbent assay (ELISA), one clone was found to have high affinity to rhG-CSF antigen. DNA sequencing confirmed that the heavy chain variable fragment (VH) was 366 bp, the light chain variable fragment (VL) was 322 bp, and that the whole gene of ScFv was 733 bp. In E.coli HB2151, the soluble ScFv-G-CSF was expressed mainly in the periplasm. The antibody production rate in total protein was 20%—25%. Western-blot analysis showed that the molecular weight of ScFv was 31 kD.
A Double‐Blind, Placebo‐Controlled Study of Nortriptyline and Bromocriptine in Male Alcoholics Subtyped by Comorbid Psychiatric Disorders (1995)

This double-blind, placebo-controlled, 6-month follow-up treatment study investigated the efficacy of bromocriptine and nortriptyline in attenuating drinking behavior and psychiatric symptoms in 216 male alcoholic patients subtyped by comorbid psychiatric disorder(s). Three well-defined subtypes were examined: alcoholism only, alcoholism + affective/anxiety disorder, and alcoholism + antisocial personality disorder. It was hypothesized that both medications would relieve negative affective symptoms associated with alcohol use and would be particularly effective for the affective/anxiety subgroup. Contrary to our predictions, the only significant effects found were with the antisocial personality disorder patients who were receiving nortriptyline. One interpretation of the results was that nortriptyline may have reduced impulsive drinking in the antisocial personality disorder subgroup by actions on serotonergic neurotransmission.
TORTS: an expert system for temporal optimization of robotic procedures (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTORTS: an expert system for temporal optimization of robotic proceduresT. L. Isenhour and P. B. HarringtonCite this: J. Chem. Inf. Comput. Sci. 1988, 28, 4, 215–221Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/ci00060a007https://doi.org/10.1021/ci00060a007research-articleACS PublicationsRequest reuse permissionsArticle Views30Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Novel Benzamides as Selective and Potent Gastrokinetic Agents. IV. Synthesis and Structure-Activity Relationships of 2-Substituted 4-Amino-N-((4-benzyl-2-morpholinyl)methyl)-5-chlorobenzamides. (1992)

A new series of 2-substituted 4-amino-N-[(4-benzyl-2-morpholinyl)methyl]-5-chlorobenzamides (4-39) including a few 4-fluorobenzyl analogues were prepared and evaluated for their gastrokinetic activity by determining their effects on the gastric emptying activity of phenol red semisolid meal in rats. The C-2 substituent comprises alkoxy and variously substituted alkoxy groups. Among the derivatives, 4-amino-N-[(4-benzyl-2-morpholinyl)methyl]-2-(n-butoxy)-5-chlorobenza mide (5), its 4-fluorobenzyl (6), and 3-methyl-2-butenyloxy analogues (22) were superior to cisapride and essentially equipotent to the 2-ethoxy analogue (1b, AS-4370 as its citrate) in gastrokinetic activity. These compounds, like AS-4370, had no dopamine D2 receptor antagonistic activity.
Nonlinear coefficient measurements for dispersionshifted fibres using self-phase modulation method at 1.55 µm (1994)

Nonlinear coefficient measurements for dispersion shifted fibres (DSFs) using the self-phase modulation (SPM) method at 1.55 µm are presented for the first time. The nonlinear Kerr refractive index n2 for various DSFs is found to be ~2.31 × 10-20 m2/W (± 5 %) for random polarisation states at 1.55 µm.
ENHANCEMENT OF THE METHANOL FORMATION FROM CO AND H2 OVER SUPPORTED RUTHENIUM CATALYSTS BY H2–H2O TREATMENT (1983)

Abstract Supported ruthenium catalysts, which was treated by H2–H2O mixture at elevated temperatures, could produce methanol from CO and H2 with 50% selectivity, and the nature of the active sites for methanol formation on these catalysts was discussed.
The performance of adaptive modulation with dynamic channel assignment in multimedia traffic (2002)

This paper proposes a multimedia adaptive modulation with dynamic channel assignment (M-AMDCA) to realize wireless multimedia communication systems. This system controls modulation parameters and the assigned slots of TDMA frame according not only to the propagation path conditions, but also to the feature of transmitted medium, say realtime traffic or non-realtime traffic, quality of service (QoS) and required bit rate. For this purpose, the proposed system measures the received carrier-to-noise plus interference power ratio (C/(N+I)) of each TDMA slot, and selects the optimum modulation parameters and the assigned slots by using the suitable channel assignment algorithm for each medium. Computer simulation confirms that the proposed M-AMDCA system can achieve very high performances for each medium under voice, video and data co-existence conditions.