gebhart/patrepeval huggingface dataset:
Visualizing science by citation mapping (1999)

Science mapping is discussed in the general context of information visualization. Attempts to construct maps of science using citation data are reviewed, focusing on the use of co-citation clusters. New work is reported on a dataset of about 36,000 documents using simplified methods for ordination, and nesting maps hierarchically. An overall map of the dataset shows the multidisciplinary breadth of the document sample, and submaps allow drilling down to the document level. An effort to visualize these data using advanced virtual reality software is described, and the creation of document pathways through the map is seen as a realization of Bush's (1945) associative trails.
Molecular cloning and characterization of the aklavinone 11-hydroxylase gene of Streptomyces peucetius subsp. caesius ATCC 27952 (1994)

The gene encoding aklavinone 11-hydroxylase of Streptomyces peucetius subsp. caesius ATCC 27952 was cloned and sequenced. The deduced amino acid sequence of the gene contains at least two common motifs of well-conserved amino acid sequences of several flavin-type bacterial hydroxylases. The hydroxylase gene is apparently transcribed from a single transcriptional start point. The phenotype of a dnrF mutant generated by gene disruption supports the idea that the dnrF gene encodes aklavinone 11-hydroxylase.
Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease (1999)

Enhanced IL-6/sIL-6R-mediated immune and inflammatory responses may be implicated, at least partly, in the continuation of intestinal inflammation in patients with IBD.
Local Texture Patterns ¿ A Univariate Texture Model for Classification of Images (2008)

Texture is an important spatial feature useful for identifying objects or regions of interest in an image. In this paper a new spatial method of texture model is proposed and a comparison of some of the histogram based texture models is carried out. This paper presents a texture analysis operator based on 'local texture patterns (LTP)'. The global image texture is modeled by 'pattern spectrum' which is an occurrence histogram of LTP over the image. The operator is designed as a gray-scale and rotational invariant texture measure on a local neighborhood. The efficiency of the proposed texture model is tested with classification of images based on log-likelihood similarity measure. The results show that the proposed method provides a very good and robust performance.
Progressive Depletion of Peripheral B Lymphocytes in 4-1BB (CD137) Ligand/I-Eα-Transgenic Mice (2001)

Interaction of 4-1BB (CD137) and its ligand (4-1BBL) is thought to positively regulate cell-mediated and humoral immune responses. We have prepared transgenic mouse strains that express 4-1BBL cDNA under the control of MHC class II I-Ealpha promoter. The 4-1BBL-transgenic mice show progressive splenomegaly and selective depletion of B220(+) B cells accompanied with low levels of circulating IgG and defective humoral responses to Ag challenge. In addition, splenocytes from the transgenic mice fail to provide stimulation for allogeneic T cells in both lymphoproliferative and CTL responses in vitro, whereas their T cells remain functionally normal. Our results reveal unexpected functions of 4-1BBL in the regulation of humoral immune responses and Ag presentation.
Achilles Tendon characterization in GDF-7 deficient mice (2006)

Growth/differentiation factors (GDFs) play a significant role in numerous skeletal tissues and processes. Previous work using the brachypod mouse has suggested that GDF-5 affects Achilles tendon composition, ultrastructure, and material behavior, as well as tendon repair. The aim of the present study was to examine the role of a related GDF family member, GDF-7 (BMP-12), in intact tendon by studying the Achilles tendon of genetically engineered knockout mice. Achilles tendons from 16-week-old GDF-7 -/- mice contained 14% less GAG/DNA than did wild type littermates (p = 0.0481), although collagen content was comparable to controls. Quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) results show that GDF-5 was upregulated two-threefold in response to the absence of GDF-7 protein. GDF-6 was also upregulated in knockouts, but to a lesser extent (twofold, p = 0.0013). On an ultrastructural level, GDF-7 deficient Achilles tendons exhibited a shift towards smaller diameter fibrils which resulted in a small but significant reduction in mean fibril diameter (-8%, p = 0.05). GDF-7 deficiency did not noticeably affect the expression of fibrillar collagens (I, III, V) or tendon proteoglycans (decorin, fibromodulin, lumican, biglycan, versican, aggrecan). Differences in tendon composition and ultrastructure were not biologically significant enough to have a noticeable effect on the structural or material behavior of the tendons. These results demonstrate that GDF-7 deficiency has a subtle effect on the composition and ultrastructure of murine Achilles tendon. The small magnitude of the observed differences may be due to overcompensation by related GDF family members.
Design and implementation of packet filter firewall using Binary Decision Diagram (2011)

Packet filtering is the one of the major contemporary firewall design techniques. An important design goal is to arrive at the decision at the packet only. Implementation of such packet filter using Binary Decision Diagram (BDD) gives more advantages in terms of memory usage and look up time. In the case of the list-based packet filter firewall where rules are checked one by one for each incoming packet, the time taken to decide on a packet is proportional to the number of rules. The performance is improved with rule promotion but that itself a slow procedure. In this work we present a BDD-based approach which gives much better result in terms of number of comparisons or accesses the rule list make. Results on 1 million packets show that for most-accept packets, on an average, 75% reduction happens in such comparisons when BDD-based approach is used over list-based with promotion approach. For most-reject packets this reduction is nearly 34%.
Infectious Morbidity Associated with Long-Term Use of Venous Access Devices in Patients with Cancer (1993)

The incidence of infections per device-day was 12 times greater with catheters than with ports. Patients with solid tumors were the least likely to have device-related infectious morbidity compared with those with hematologic cancers. The reasons for the difference in infectious complications is uncertain but may be attributable to type of disease, intensity of therapy, frequency with which devices are accessed, or duration of neutropenia.
Neurosurgical burr hole placement using the Microsoft HoloLens (2018)

PURPOSE: Tracked navigation systems are generally impractical in bedside neurosurgical procedures, such as a twist-drill crainiostomy for the removal of a subdural hematoma, where the use of navigation could optimize the placement of the drill in relation to the underlying fluid. We use the Microsoft HoloLens to display a hologram floating in the patient’s head to mark a burr hole on the skull. METHODS: A 3D model of the head, hematoma and burr hole is created from CT and imported to the HoloLens. The hologram is interactively registered to the patient and the burr hole is marked on the skull. 3D Slicer, Unity, and Visual Studio were used for software development. The system was tested by 6 inexperienced and 1 experienced users. They each performed 6 registrations on phantoms with fiducial markers placed at 3 plausible burr hole locations on each side of the head. Registration accuracy was determined by measuring the distance between the holographic and physical markers. RESULTS: Inexperienced users placed 98% of the markers within the clinically acceptable range of 10 mm in an average time of 4:46 min. The experienced user placed 100% of the markers within the acceptable range in an average time of 2:52 min. CONCLUSION: It is feasible to mark a neurosurgical burr hole location with clinically acceptable accuracy using the Microsoft HoloLens, within an acceptable length of time. This technology may also prove useful for procedures that require higher accuracy of drill location and drain trajectory such as the placement of external ventricular drains.
Receptor for AGE (RAGE): Weaving Tangled Webs Within the Inflammatory Response (2007)

The family of RAGE ligands, including Advanced Glycation Endproducts (AGEs), S100/calgranulins, High Mobility Group Box-1 (HMGB1) and amyloid beta peptide (Abeta) and beta-sheet fibrils are highly enriched in immune and inflammatory foci. In parallel, upregulation of Receptor for AGE (RAGE) is noted in diverse forms of inflammation and autoimmunity, based on experiments examining human tissues as well as animal models. Indeed, prior to the demonstration that S100/calgranulins were signal transduction ligands of RAGE, these molecules were considered "biomarkers" of disease and disease activity in disorders such as colitis and arthritis. Premiere roles for RAGE in advancing cellular migration implicate this receptor in targeting immune cells to vulnerable foci. Once engaged, ligand-RAGE interaction in inflammatory and vascular cells amplifies upregulation of inflammatory cytokines, adhesion molecules and matrix metalloproteinases (MMPs). Discerning the primal versus chronic injury-provoking roles for this ligand-receptor interaction is a challenge in delineating the functions of the ligand/RAGE axis. As RAGE is expressed by many of the key cell types linked integrally to the immune response, we propose that the sites and time course of ligand-RAGE stimulation determine the phenotype produced by this axis. Ultimately, drawing the fine line between antagonism versus stimulation of the receptor in health and disease will depend on the full characterization of RAGE in repair versus injury.
Editor’s (half) Page (1954)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text , "Editor’s (half) Page," J. Opt. Soc. Am. 44, 483-483 (1954) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
An evolutionary treasure: unification of a broad set of amidohydrolases related to urease (1997)

The recent determination of the three-dimensional structure of urease revealed striking similarities of enzyme architecture to adenosine deaminase and phosphotriesterase, evidence of a distant evolutionary relationship that had gone undetected by one-dimensional sequence comparisons. Here, based on an analysis of conservation patterns in three dimensions, we report the discovery of the same active-site architecture in an even larger set of enzymes involved primarily in nucleotide metabolism. As a consequence, we predict the three-dimensional fold and details of the active site architecture for dihydroorotases, allantoinases, hydantoinases, AMP-, adenine and cytosine deaminases, imidazolonepropionase, aryldialkylphosphatase, chlorohydrolases, formylmethanofuran dehydrogenases, and proteins involved in animal neuronal development. Two member families are common to archaea, eubacteria, and eukaryota. Thirteen other functions supported by the same structural motif and conserved chemical mechanism apparently represent later adaptations for different substrate specificities in different cellular contexts.
Stimulation of High-Temperature Sandstone Formations From West Africa With Chelating Agent-Based Fluids (2008)

Summary Fluids based on chelating agents have been developed for matrix stimulation of high-temperature sandstone formations. These fluids dissolve sizeable amounts of calcite and clays and maintain high levels of dissolved metal in solution over time with minimal precipitation. A series of field samples from high-temperature (149°C) sandstone reservoirs in a West African formation bear carbonate concentrations ranging from 2% to 37% (w/w). The effects of matrix treatment using a chelating agent-based system on these field samples were studied using coreflood and slurry reactor experiments. Linear coreflood test data show dramatic increases in the formation permeability after treatment with the chelating agent-based fluid. The improvement in permeability is ascribed to the removal of carbonate minerals and soluble clays, without secondary metal precipitation. Slurry reactor tests elucidated the kinetics of mineral dissolution in mechanically ground field samples. Treatment with acidic chelant fluids generated high levels of dissolved calcium, silicon, and aluminum that remained in solution over time. For comparison, conventional mineral-acid treatment of the field samples generated high levels of metals in solution that declined over the same period of time, which is indicative of secondary precipitation. The effectiveness of the chelant fluid for stimulation of this high-temperature formation was confirmed through increased formation permeability and high levels of dissolved minerals.
GuidedStyle: Attribute Knowledge Guided Style Manipulation for Semantic Face Editing (2020)

Although significant progress has been made in synthesizing high-quality and visually realistic face images by unconditional Generative Adversarial Networks (GANs), there still lacks of control over the generation process in order to achieve semantic face editing. In addition, it remains very challenging to maintain other face information untouched while editing the target attributes. In this paper, we propose a novel learning framework, called GuidedStyle, to achieve semantic face editing on StyleGAN by guiding the image generation process with a knowledge network. Furthermore, we allow an attention mechanism in StyleGAN generator to adaptively select a single layer for style manipulation. As a result, our method is able to perform disentangled and controllable edits along various attributes, including smiling, eyeglasses, gender, mustache and hair color. Both qualitative and quantitative results demonstrate the superiority of our method over other competing methods for semantic face editing. Moreover, we show that our model can be also applied to different types of real and artistic face editing, demonstrating strong generalization ability.
Minimally Invasive Coronary Bypass (1998)

inimally invasive techniques for coronary surgery are gaining increased attention, but not without debate.We recognize that in criticizing a new technique, it is necessary to have not only a firm opinion but also a willingness to be wrong; our purpose is to stimulate discussion and debate.Of course, it is difficult to argue against attempts to minimize the invasiveness of any procedure, but it is well to recall that the most obvious successes of minimally invasive surgery have involved technically simple operations, such as arthroscopy or cholecystectomy, which involve a minimum of precision and almost no sewing.The circumstances are different, however, when one attempts to apply the same theory and strategy to physiologically and technically complex cardiac operations.
Theoretical and experimental study of GaAs IMPATT oscillator efficiency (1973)

This theoretical and experimental study was motivated by a specific need for a solid-state microwave generator with an output efficiency exceeding 20% and focused on the properties of GaAs avalanche transit-time devices. First, the dependence of the ionization rates and drift carrier velocities as a function of electric field and temperature is established. Then several methods of calculation, exact enough to take into account all the important efficiency-limiting effects in the device, are discussed and used to derive theoretical figures for the efficiency of a GaAs IMPATT oscillator, special attention being given to the influence of the doping profile. Finally, the experimental study is described, including device realization and experimentally measured efficiencies, and a comparison between these and the calculated values is done. It is shown that the best calculated performances can reach 30% efficiency and that it is possible to obtain experimentally cw oscillation efficiencies exceeding 20% with GaAs IMPATT devices having special types of doping profile.
Lineage specification of neuronal precursors in the mouse spinal cord. (1995)

We have investigated the differentiation potential of precursor cells within the developing spinal cord of mice and have shown that spinal cord cells from embryonic day 10 specifically give rise to neurons when plated onto an astrocytic monolayer, Ast-1. These neurons had the morphology of motor neurons and > 83% expressed the motor neuron markers choline acetyltransferase, peripherin, calcitonin gene-related peptide, and L-14. By comparison, < 10% of the neurons arising on monolayers of other neural cell lines or 3T3 fibroblasts had motor neuron characteristics. Cells derived from dorsal, intermediate, and ventral regions of the spinal cord all behaved similarly and gave rise to motor neuron-like cells when plated onto Ast-1. By using cells that expressed the lacZ reporter gene, it was shown that > 93% of cells present on the Ast-1 monolayers were motor neuron-like. Time-lapse analysis revealed that the precursors on the Ast-1 monolayers gave rise to neurons either directly or following a single cell division. Together, these results indicate that precursors in the murine spinal cord can be induced to differentiate into the motor neuron phenotype by factors produced by Ast-1 cells, suggesting that a similar factor(s) produced by cells akin to Ast-1 may regulate motor neuron differentiation in vivo.
Influence of acute upper respiratory tract infection on the absorption of inhaled insulin using the AERx<sup>®</sup> insulin Diabetes Management System (2005)

The results suggest that insulin can be administered via AERx iDMS to nondiabetic subjects experiencing a URTI without any statistically significant changes in insulin pharmacokinetics or pharmacodynamics, and that the necessity for dose adjustments will not differ from subjects with an acute URTI who are receiving subcutaneous insulin.
Simultaneously Dual Modification of Ni‐Rich Layered Oxide Cathode for High‐Energy Lithium‐Ion Batteries (2019)

Abstract A critical challenge in the commercialization of layer‐structured Ni‐rich materials is the fast capacity drop and voltage fading due to the interfacial instability and bulk structural degradation of the cathodes during battery operation. Herein, with the guidance of theoretical calculations of migration energy difference between La and Ti from the surface to the inside of LiNi 0.8 Co 0.1 Mn 0.1 O 2 , for the first time, Ti‐doped and La 4 NiLiO 8 ‐coated LiNi 0.8 Co 0.1 Mn 0.1 O 2 cathodes are rationally designed and prepared, via a simple and convenient dual‐modification strategy of synchronous synthesis and in situ modification. Impressively, the dual modified materials show remarkably improved electrochemical performance and largely suppressed voltage fading, even under exertive operational conditions at elevated temperature and under extended cutoff voltage. Further studies reveal that the nanoscale structural degradation on material surfaces and the appearance of intergranular cracks associated with the inconsistent evolution of structural degradation at the particle level can be effectively suppressed by the synergetic effect of the conductive La 4 NiLiO 8 coating layer and the strong TiO bond. The present work demonstrates that our strategy can simultaneously address the two issues with respect to interfacial instability and bulk structural degradation, and it represents a significant progress in the development of advanced cathode materials for high‐performance lithium‐ion batteries.
Understanding Fiber Optics (2015)

Aimed at anyone who wants to learn quickly, this book focuses on the technical details of fibre optics, the fibres themselves, the tools used to work the fibres, and the associated devices used to connect fibre optics.
Observations of Instability in Semiconductors caused by Heavily Injected Minority Carriers (1962)

A new class of instability caused by the combination of heavily injected minority carriers and special geometrical shape of specimen has been observed. Current-voltage characteristics and the dependence of Hall voltage on the current show that the high density electron-hole cloud is produced in the specimen. Experimental results also show that the local high electric field region or abrupt change in the electric field strength along the specimen is indispensable for getting the instability. Coherent oscillation has been observed with application of high electric field, oscillation frequency ranging from 400 kc to 1 mc. The effect of magnetic field, both longitudinal and transverse, is to suppress the oscillation, which can be attributed to the enhanced recombination of carriers at the surface. Some tentative models for the understanding of the mechanism of the oscillation are give with brief discussions.
Asymmetric Non-Commodity Output Responses to Commodity Price Shocks (2021)

This paper focuses on identifying potential asymmetric responses of non-commodity output growth in times of positive and negative commodity terms-of-trade shocks. Using a sample of 27 oil-exporting countries and a panel VAR method, the study finds: 1) the short-and medium-run response of real non-commodity GDP growth is larger for negative shocks than positive shocks; 2) this asymmetry is more pronounced in countries with weak pre-existing fundamentals–high levels of public debt and low levels of international reserves–which also serve to amplify the volatility of the response; 3) the output response to positive shocks is stronger following a sustained period of CTOT increases, while the impact of negative shocks on output are more damaging when they occur after a period of CTOT decline.
Peculiar width dependence of the electronic properties of carbon nanoribbons (2006)

Nanoribbons (nanographite ribbons) are carbon systems analogous to carbon nanotubes. We characterize a wide class of nanoribbons by a set of two integers $⟨p,q⟩$, and then define the width $w$ in terms of $p$ and $q$. Electronic properties are explored for this class of nanoribbons. Zigzag (armchair) nanoribbons have similar electronic properties to armchair (zigzag) nanotubes. The band gap structure of nanoribbons exhibits a valley structure with streamlike sequences of metallic or almost metallic nanoribbons. These sequences correspond to equiwidth curves indexed by $w$. We reveal a peculiar dependence of the electronic property of nanoribbons on the width $w$.
Prolonged early G1 arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle–coupled loss of IRF4 (2012)

Dysregulation of cyclin-dependent kinase 4 (CDK4) and CDK6 by gain of function or loss of inhibition is common in human cancer, including multiple myeloma, but success in targeting CDK with broad-spectrum inhibitors has been modest. By selective and reversible inhibition of CDK4/CDK6, we have developed a strategy to both inhibit proliferation and enhance cytotoxic killing of cancer cells. We show that induction of prolonged early-G(1) arrest (pG1) by CDK4/CDK6 inhibition halts gene expression in early-G(1) and prevents expression of genes programmed for other cell-cycle phases. Removal of the early-G(1) block leads to S-phase synchronization (pG1-S) but fails to completely restore scheduled gene expression. Consequently, the IRF4 protein required to protect myeloma cells from apoptosis is markedly reduced in pG1 and further in pG1-S in response to cytotoxic agents, such as the proteasome inhibitor bortezomib. The coordinated loss of IRF4 and gain of Bim sensitize myeloma tumor cells to bortezomib-induced apoptosis in pG1 in the absence of Noxa and more profoundly in pG1-S in cooperation with Noxa in vitro. Induction of pG1 and pG1-S by reversible CDK4/CDK6 inhibition further augments tumor-specific bortezomib killing in myeloma xenografts. Reversible inhibition of CDK4/CDK6 in sequential combination therapy thus represents a novel mechanism-based cancer therapy.