gebhart/patrepeval huggingface dataset:
Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases (2011)

Abscisic acid (ABA) is an essential hormone for plants to survive environmental stresses. At the center of the ABA signaling network is a subfamily of type 2C protein phosphatases (PP2Cs), which form exclusive interactions with ABA receptors and subfamily 2 Snfl-related kinase (SnRK2s). Here, we report a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors. In the complex, the kinase activation loop docks into the active site of PP2C, while the conserved ABA-sensing tryptophan of PP2C inserts into the kinase catalytic cleft, thus mimicking receptor-PP2C interactions. These structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation and highlight a new paradigm of kinase-phosphatase regulation through mutual packing of their catalytic sites.
Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency. (1990)

Cathepsin D, an aspartic lysosomal proteinase, is overexpressed by breast cancer cells and highly correlated with the occurrence of metastasis in patients. We used an adenovirus transformed rat cell line that does not secrete cathepsin D, to study the consequences of transfecting human cathepsin D cDNA. Overexpression of human cathepsin D in stable transfectant clones, results in higher initial growth rates in low serum conditions, overgrowth at high cell densities resulting in stellate aggregates, and greater anchorage-independent growth in soft agar. The metastatic activity (mostly in liver) of cathepsin D clones injected into athymic mice was significantly higher than that of control clones. These results show that overexpression of cathepsin D increases the transformed phenotype of malignant cells in vitro and their metastatic potency in vivo.
A Method to Design Single Error Correction Codes With Fast Decoding for a Subset of Critical Bits (2015)

Single error correction (SEC) codes are widely used to protect data stored in memories and registers. In some applications, such as networking, a few control bits are added to the data to facilitate their processing. For example, flags to mark the start or the end of a packet are widely used. Therefore, it is important to have SEC codes that protect both the data and the associated control bits. It is attractive for these codes to provide fast decoding of the control bits, as these are used to determine the processing of the data and are commonly on the critical timing path. In this brief, a method to extend SEC codes to support a few additional control bits is presented. The derived codes support fast decoding of the additional control bits and are therefore suitable for networking applications.
Female mice lacking Xist RNA show partial dosage compensation and survive to term (2016)

X-chromosome inactivation (XCI) compensates for differences in X-chromosome number between male and female mammals. XCI is orchestrated by Xist RNA, whose expression in early development leads to transcriptional silencing of one X chromosome in the female. Knockout studies have established a requirement for Xist with inviability of female embryos that inherit an Xist deletion from the father. Here, we report that female mice lacking Xist RNA can, surprisingly, develop and survive to term. Xist-null females are born at lower frequency and are smaller at birth, but organogenesis is mostly normal. Transcriptomic analysis indicates significant overexpression of hundreds of X-linked genes across multiple tissues. Therefore, Xist-null mice can develop to term in spite of a deficiency of dosage compensation. However, the degree of X-autosomal dosage imbalance was less than anticipated (1.14-fold to 1.36-fold). Thus, partial dosage compensation can be achieved without Xist, supporting the idea of inherent genome balance. Nevertheless, to date, none of the mutant mice has survived beyond weaning stage. Sudden death is associated with failure of postnatal organ maturation. Our data suggest Xist-independent mechanisms of dosage compensation and demonstrate that small deviations from X-autosomal balance can have profound effects on overall fitness.
A New Segmentation Algorithm to Stock Time Series Based on PIP Approach (2007)

Stock time series segmentation is one of the fundamental components in stock time series data mining. And the segmentation is often used for the trend analysis. In this paper, a new stock time series segmentation algorithm is proposed based on PIP(Perceptually Important Point) approach. This proposed segmentation method contributes to containing both the important data points and the primitive trends like uptrend and downtrend, while most of the current algorithms only contain one aspect of that. The proposed segmentation algorithm is proved to be more efficient and effective in reserving the trends and less complexity than those combined split-and- merge piecewise linear approximation segmentation algorithms.
Workload characterization for operator-based distributed stream processing applications (2010)

Operator-based programming languages provide an effective development model for large scale stream processing applications. A stream processing application consists of many runtime deployable software processing elements (PE) that work in flows to process incoming messages. Operators (OP) are logical building blocks hosted by PEs. One or more OPs can be fused into a PE at compile-time. Performance optimization for our streaming system includes compile-time fusion optimization and runtime PE-to-host deployment. One of the goals of an optimized stream application is to use minimal computing resource to sustain maximal message throughput.
Sensing of the weld pool depth with neural network and fuzzy control of seam tracking (2002)

Deals with the problem concerning the sensing of the weld pool and the tracking of the welding line with welding robots. In order to obtain a good quality of the welding result, it is important to control the weld pool depth and to keep the torch posture constant regardless of the external disturbance. First, a new method is proposed for sensing the weld pool depth with the neural network. The depth is kept constant regardless of the disturbance, such as the variation of the groove gap, with the fuzzy controller. Next, the method of seam tracking is discussed when the pipe is joined to the plane. The CCD camera and the laser are used to detect the welding line and to control the torch posture. The torch axis /spl phi/ of the robot, its root axis /spl theta/, and the torch height are controlled with the fuzzy controller. The validity of the neural network and the fuzzy controller is verified by performing the experiments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effects of the DNA topoisomerase II inhibitor merbarone in male mouse meiotic divisions in vivo: Cell cycle arrest and induction of aneuploidy (1997)

In order to clarify possible risks of aneuploidy induction in germ cells by cancer chemotherapy we studied effects of a non complex-stabilizing DNA topoisomerase II (topo II) inhibitor merbarone in male mouse meiotic divisions in vivo. Two cytogenetic approaches were used: (1) C-banding on meiotic chromosome preparations and (2) analysis of spermatid micronuclei (MN) combined with immunocytochemical staining of kinetochore proteins using CREST serum. For comparison, another topo II inhibitor, VP-16, known to form cleavable complexes, was studied. The microdissection technique of mouse seminiferous tubules enabled us to carefully examine effects at specific phases of meiosis. Merbarone injections increased percentages of polyploid and hypoploid metaphase II spermatocytes at time intervals corresponding to the treatment of the first meiotic division and diplotene-diakinesis. The highest level of MN induction (5.8 MN/1000 spermatids, P < 0.001) was observed in animals injected 48 hours before the harvest, corresponding to the treatment of diplotene-diakinesis spermatocytes. Most of the induced MN (80%) contained kinetochore signals, indicating that they resulted from detachment of a whole bivalent or chromosome from the meiotic spindle. The high frequency of MN with two kinetochore signals at opposite sides (33%) most likely denotes lagging of whole bivalents during MI. Inhibition of cell proliferation was determined by scoring cells arrested at different phases of MI and MII. All groups of treated animals showed a clear increase in the frequency of arrested divisions compared to controls (P < 0.001). Thus, merbarone was shown to severely damage normal meiotic processes.
Windows programmer's guide to Borland C++ Tools (1992)

A guide for programmers offering information on and insights in the variety of tools bundled with Borland C++.
Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). IV. Distinct H-2-linked Ir genes control antibody responses to different HBsAg determinants on the same molecule and map to the I-A and I-C subregions. (1984)

We have previously demonstrated that the murine humoral immune responses to the group-specific a and subtype-specific d/y determinants of hepatitis B surface antigen (HBsAg) are controlled by H-2-linked immune response (Ir) genes. High responder (H-2d,q), intermediate responder (H-2a greater than b greater than k) and nonresponder (H-2f,s) haplotypes have been identified (8, 9). The kinetics and specificity of in vivo antibody production after HBsAg immunization in congeneic, H-2-recombinant strains was analyzed to further define relevant Ir genes and their influence on the immune response to distinct antigenic determinants. These studies indicate that the humoral anti-HBs response is regulated by at least two Ir genes, one in the I-A subregion (Ir-HBs-1) and one in the I-C subregion (Ir-HBs-2) of the murine H-2 complex. Ir-HBs-1 regulates the primary responses to all HBsAg determinants, whereas the influence of Ir-HBs-2 is determinant specific, affecting the responses to the d or y determinants. The anti-a response is regulated exclusively by Ir-HBs-1. Strains possessing only the Ir-HBs-2 gene [B10.S(9R) and B10.HTT] produce no anti-a response and a subtype-specific antibody response is detected only after secondary or tertiary immunization. In contrast, the influence of Ir-HBs-2 in the presence of Ir-HBs-1 is detected upon primary immunization and is additive rather than exclusive. There is also suggestive evidence that the presence of the Ek molecule, at least in the context of I-Ak, may have a suppressive influence on the anti-HBs response. Additionally, HBsAg-specific, T cell proliferative responses were H-2 restricted and the kinetics and specificity of T cell proliferative responses paralleled in vivo antibody production. These data indicate that, although the I-A subregion exerts a dominant influence, distinct Ir-HBs genes, mapping in separate I subregions, control immune responses to alternate HBsAg determinants on the same protein molecule.
Finite field wavelet transforms and multilevel error protection (2002)

A technique for providing unequal error protection is investigated. It relies on a transform approach to coding and makes use of the wavelet transform over finite fields. Reed-Muller codes, concatenated codes and dual codes are examined.
Studies on Composite Extrudable Propellant with varied Burning Rate Pressure Index 'n' (1989)

This paper discusses the development of composite propellantextrusion technique and the study of burning rate pressure indices nwith respect to compositional variations. The n is found to vary from0.35 to plateau and plateau to mesa by suitable compositionalmodifications. Compositional influence on burning rate with specificreference to plateau and mesaburning additives is described. Detailsof the process parameters like fluidity of the slurry, extrusion pressure,extrusion rate and die-swell are presented. This propellant is based onISRO-CTPB binder using ISRO-AP as oxidizer. Ammonium perchlorate (AP) particle size variation and inclusion of additives likePVC, lead stearate, ammonium sulphate, lithium fluoride etc. are foundto influence the burning rate pressure index n.
Radio-frequency spectral analysis for SONET framing recognition and performance monitoring (2001)

We have experimentally demonstrated what to our knowledge is a novel framing-recognition and performance-monitoring scheme for the synchronous optical network (SONET) using the radio-frequency spectral analysis and taking advantage of the intrinsic data structure of the SONET signal itself. This scheme does not require access to individual bits or recovered clock and data. It can recognize SONET frame-alignment sequences and generate framing pulses correspondingly. It also provides an analog indicator that varies monotonically with the in-band signal-to-noise ratio and hence the channel bit error rate. In principle the proposed scheme can be scaled to data rates of OC-192 and higher.
Modifying the netlist after placement for performance improvement (2002)

A postplacement netlist modifier which improves the performance of a placed netlist is presented. Iterative technology remapping operations customize the most critical path timing for physical wire capacitances that are unique to a standard-cell placement. The improvement is reached through three operations: buffer tree resynthesis, gate drive resizing, and gate reconnection. Results show up to a 13% reduction in circuit timing for MCNC benchmarks that have already been optimized at the logic level for timing.
Computational sports broadcasting: Automated director assistance for live sports (2013)

Live sports broadcast is seeing a large increase in the number of cameras used for filming. More cameras can provide better coverage of the field and a wider range of experiences for viewers. However, choosing optimal cameras for broadcast demands a high level of concentration, awareness and experience from sports broadcast directors. We present an automatic assistant to help select likely candidates from a large array of possible cameras. Sports directors can then choose the final broadcast camera from the reduced suggestion set. Our assistant uses both widely acknowledged cinematography guidelines for sports directing, as well as a data-driven approach that learns specific styles from directors.
Dielectric relaxation spectra of water adsorbed on lysozyme (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDielectric relaxation spectra of water adsorbed on lysozymeS. C. Harvey and P. HoekstraCite this: J. Phys. Chem. 1972, 76, 21, 2987–2994Publication Date (Print):October 1, 1972Publication History Published online1 May 2002Published inissue 1 October 1972https://pubs.acs.org/doi/10.1021/j100665a011https://doi.org/10.1021/j100665a011research-articleACS PublicationsRequest reuse permissionsArticle Views533Altmetric-Citations196LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Über die soziale Funktion von Verantwortung und Verantwortlichkeit (1989)

„Der Begriff der Verantwortung (scil: wird) eigenartigerweise in der Soziologie (wie übrigens auch in der Pädagogik) trotz seiner eminenten sozialen Bedeutung kaum diskutiert.“ An der Richtigkeit dieser Beobachtung von Dieter Claessens (1963:12) hat sich bis heute ebensowenig geändert wie an derjenigen Ernst von Schenks (1956:179) über die „durchaus lebendige Vielfalt und Häufigkeit bis zum Überdruß, in der heute die Vokabel der Umgangssprache einverleibt ist“. Die Ubiquität des Wortes, seit seiner Aufwertung zum „Prinzip Verantwortung“ (Jonas 1979, Saladin 1984) noch gesteigert, steht in einem auffallenden Gegensatz zum Fehlen systematischer Erörterungen des gemeinten Sachverhalts außerhalb von Philosophie und Theologie. Aber auch dort ist die Kategorie recht neuen Datums: die grundlegende Studie Wilhelm Weischedels datiert von 1933, die früheste Erwähnung in einem philosophischen Wörterbuch nach F. v. Schenk von 1954. „In der Theologie gewinnt der Begriff der Verantwortung seit dem Ende des Ersten Weltkrieges zunehmend an Gewicht. Er wird nach dem Zweiten Weltkrieg, ergänzt durch den der verantwortlichen Gesellschaft, zum Gemeinplatz.“ (Evangelisches Soziallexikon 1980:1358). Lediglich in der Jurisprudenz ist ein älterer kategorialer Gebrauch nachzuweisen: Man hat sich vor dem (Straf-)Richter zu verantworten, man wird für das feierlich verpfändete Wort zur Rede gestellt.
Degradation of type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explant cultures (1997)

MMP activity correlates with degradation of type II collagen, but not proteoglycan, in cartilage cultures. Interstitial collagenase, collagenase 3, and gelatinases are all likely to contribute to cleavage and removal of collagen from the cartilage matrix. The proteinase(s) responsible for aggrecan breakdown remains unclear.
Multiple Insertion of Unsaturated Molecules into the Zr−N Bonds of [<i>η</i><sup>5</sup>:<i>σ</i>-Me<sub>2</sub>A(C<sub>9</sub>H<sub>6</sub>)(C<sub>2</sub>B<sub>10</sub>H<sub>10</sub>)]Zr(NMe<sub>2</sub>)<sub>2</sub> (A = C, Si) (2003)

The compounds [η5:σ-Me2A(C9H6)(C2B10H10)]Zr(NMe2)2 (A = C, Si) reacted with CS2, PhCN, CH2CHCN, nBuNCS, and PhNCO to give the mono-, di-, and triinsertion products, depending upon the substrates. These unsaturated substances inserted exclusively into the Zr−N bonds, and the Zr−C(cage) bond remains intact in all reactions. It is believed that the preference of Zr−N over Zr−C(cage) insertion is governed by steric factors. The metal amide compounds also initiated the polymerization of CH2CHCN to produce poly(acrylonitrile) and catalyzed the trimerization of PhNCO. On the other hand, they reacted with methyl methacrylate to afford [{η5:σ-Me2A(C9H6)(C2B10H10)}Zr(OCH3)(μ-OCH3)]2 and CH2C(Me)CONMe2. All insertion products were fully characterized by various spectroscopic data, elemental analyses, and X-ray diffraction studies.
The Churchill Syndrome (2020)

Abstract This chapter focuses on the way in which political actors of different stripes have used the idea of Churchill as a means of self-validation. It explores how, in the decades after his death, Churchill became a key point of reference in Anglo-American relations, a theme which intensified after the terrorist attacks of 9/11. The chapter also examines how Churchill has been used by those on both sides of the long-running debate about British membership of the European Union. Although Remainers invoked the memory of the 1946 ‘United States of Europe’ speech, they struggled to sell Churchill as a complex figure who was prepared to make concessions on British sovereignty in the interests of future peace. The ingrained, bulldog image remained hegemonic—even though Churchill’s popular reputation had shifted in subtle but significant ways since the end of the Second World War.
Polysaccharide conformation. Part VII. Model building computations for α-1,4 galacturonan and the kinking function of<scp>L</scp>-rhamnose residues in pectic substances (1971)

D-Galacturonic acid residues in α-1,4 linked chains are shown, by 1H n.m.r. spectroscopy of oligomers in solution and by mathematical model-building to have the Reeves C1 conformation. The probable conformation of the polymer in the solid state is also derived. Calculations show that multiple-helix formation is impossible for α-1,4-galacturonan; therefore, despite physical similarities, the gel properties of pectins and pectates cannot be explained in the same terms as for agar and carrageenans. There is, however, a strong analogy with the other biological-network polysaccharides in that anomalous units are interspersed to form ‘kinks’ which interrupt any tendency to an ordered chain conformation; these units are L-rhamnose in pectic substances and correspond to galactose 6-sulphate in carrageenans and to L-iduronic or D-glacuronic acid in mucopolysaccharides.
RETINAL ADHESIVENESS IN SURGICALLY ENUCLEATED HUMAN EYES (1994)

Retinal adhesion in humans appears to involve similar mechanisms as in rabbits and monkeys.
Coronary Sinus Morphology in Patients With Atrioventricular Junctional Reentry Tachycardia and Other Supraventricular Tachyarrhythmias (1995)

The proximal coronary sinus in patients with AVJRT was significantly different from a control population. The ostium was 44% larger and remained more dilated to at least 10 mm from the ostium. The appearance was like a wind sock in AVJRT patients and tubular in the control patients. These findings may have important implications for arrhythmia pathogenesis in such patients.
Fiber-optic subcarrier multiplexing video transport employing multilevel QAM (1990)

The technical feasibility of applying a fiber-optic multilevel QAM (quadrature amplitude modulation) subcarrier multiplexing scheme to a multichannel conventional TV signal transport is explored. This transport scheme has some advantageous features. Because a digital subcarrier modulation scheme is used, a high-quality transmission performance is expected to be achieved, if the bit error is sufficiently small over a transmission line and the required carrier-to-noise ratio (CNR) is relatively small among the many candidates of subcarrier modulation schemes. The use of multilevel modulation allows the bandwidth to be efficiently utilized; consequently, up to 40-channel uncompressed digital TV signals are estimated to be accommodated in the frequency region of the VHF and UHF bands, where well-developed and inexpensive electronics can be easily applied.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hybrid-selection/optimum combining (2002)

We propose and study hybrid-selection/optimum combining (H-S/OC). With this technique, L out of M diversity branches are weighted and combined to maximize the output signal-to-interference-plus-noise ratio. We first present computer simulation results for L=1, showing that selecting the antenna with the largest signal-to-interference power ratio (S/I), rather than the largest signal power, can significantly improve performance when a few strong interferers are present. Our results with equal-power interferers show that H-S/OC can greatly suppress more than L interferers when M>L. Finally, we present computer simulation results for an ANSI-136 TDMA cellular system which show a 7-fold increase in capacity for H-S/OC with L=1, M=12 or L=2, M=4. Thus, H-S/OC offers the potential for systems to operate with multiple strong cochannel interferers and obtain diversity gain with only a few receiver chains.
Evaluating The Online Capabilities Of Onset Detection Methods. (2012)

[TODO] Add abstract here.