gebhart/patrepeval huggingface dataset:
Abstract 2606: Antitumor activity of the selective RAF inhibitor HM95573 in melanoma (2015)

Abstract The mitogen-activated protein kinase (MAPK) pathway is particularly important for the survival and proliferation of tumor cells. Activation of the MAPK pathway due to mutations in BRAF and NRAS is considered one of the causes of melanoma. HM95573 is a novel, highly potent RAF kinase inhibitor. Biochemically assayed for over 120 kinases, HM95573 showed the high selectivity toward BRAF mutant and CRAF kinases. The half maximal inhibition concentrations (IC50) of HM95573 against BRAFWT, BRAFV600E and CRAF kinases were 41nM, 7nM and 2nM, respectively. The strongly inhibited kinases subsequent to RAF kinases appeared to be CSF1R (44nM), DDR1 (77nM) and DDR2 (182 nM). HM95573 potently inhibited the growth of mutant BRAF melanoma cell lines such asA375 (IC50: 57nM) and SK-MEL-28 (69nM) and of mutant NRAS melanoma cell lines such asSK-MEL-2 (53nM) and SK-MEL-30 (24nM). In addition, the phosphorylations of MEK and ERK downstream kinases associated with cell proliferation were effectively inhibited with treatment of HM95573in mutant BRAF and mutant NRAS melanoma cells.HM95573inhibited the downstream signaling in melanoma cells even in the presence of HGF which is known to mediate innate resistance to RAF inhibitors. HM95573 showed the excellent antitumor activity in mouse models xenografted with both of BRAF mutation cell lines (e.g. A375 and SK-MEL-28) and NRAS mutation cell lines (such as SK-MEL-2 and SK-MEL-30) compared to two RAF inhibitors approved in melanoma which were effective to only BRAF mutation cell lines under conditions tested. Furthermore, HM95573 did not show a potential to paradoxical activation inducing tumor growth in mouse xenograft study using A431 cuSCC (cutaneous squamous cell carcinoma)cancer cell. Now, HM95573 is currently in phase I development in patients with advanced solid tumors including melanoma in Korea. Citation Format: InHwan Bae, YoungGil Ahn, Namgoong GwangMo, SuHyeon Kim, JiYeon Song, TaeHun Song, JaeHo Lee, KyuHang Lee, Young-Mi Lee, YoungHoon Kim, KweeHyun Suh. Antitumor activity of the selective RAF inhibitor HM95573 in melanoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2606. doi:10.1158/1538-7445.AM2015-2606
A CMOS Current Steering Neurostimulation Array With Integrated DAC Calibration and Charge Balancing (2017)

An 8-channel current steerable, multi-phasic neural stimulator with on-chip current DAC calibration and residue nulling for precise charge balancing is presented. Each channel consists of two sub-binary radix DACs followed by wide-swing, high output impedance current buffers providing time-multiplexed source and sink outputs for anodic and cathodic stimulation. A single integrator is shared among channels and serves to calibrate DAC coefficients and to closely match the anodic and cathodic stimulation phases. Following calibration, the differential non-linearity is within ±0.3 LSB at 8-bit resolution, and the two stimulation phases are matched within 0.3%. Individual control in digital programming of stimulation coefficients across the array allows altering the spatial profile of current stimulation for selection of stimulation targets by current steering. Combined with the self-calibration and current matching functions, the current steering capabilities integrated on-chip support use in fully implanted neural interfaces with autonomous operation for and adaptive stimulation under variations in electrode and tissue conditions. As a proof-of-concept we applied current steering stimulation through a multi-channel cuff electrode on the sciatic nerve of a rat.
Possible surface intermediates in alkane reactions on metallic catalysts (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPossible surface intermediates in alkane reactions on metallic catalystsFrancois Garin and Gilbert MaireCite this: Acc. Chem. Res. 1989, 22, 3, 100–106Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/ar00159a003https://doi.org/10.1021/ar00159a003research-articleACS PublicationsRequest reuse permissionsArticle Views181Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
TINEL'S SIGN AND PHALEN'S TEST IN CARPAL TUNNEL SYNDROME (1992)

Tinel's sign and Phalen's test are two provocative tests used in the diagnosis of carpal tunnel syndrome. A review of the literature reveals a wide range of sensitivity for these tests. Analyzing the historical data and comparing these to the Tinel's sign and Phalen's test results of 100 individuals without carpal tunnel syndrome (200 wrists), we conclude that the Tinel's sign is not useful in the evaluation of patients with carpal tunnel syndrome, whereas Phalen's test, which has a greater sensitivity and specificity, can be of use.
Comparison of Ewing's sarcoma of bone and peripheral neuroepithelioma. An immunocytochemical and ultrastructural analysis of two primitive neuroectodermal neoplasms. (1994)

Ewing's sarcoma of bone (ESB) and peripheral neuroepithelioma (PN) are frequently considered to be different tumors. Some researchers have suggested that PN is morphologically a neuroectodermal Ewing's sarcoma. We sought to determine the extent of neuroectodermal features in conventional ESB on direct patient material (25 cases) and to compare these tumors with a similar group of readily diagnosed PNs (10 cases). Light microscopic, ultrastructural, and immunophenotypic parameters were assessed and compared for both groups. The avidin-biotin complex method was used. All tumors were antigenically intact since all stained for vimentin or at least one marker. Neuroectodermal antigens (neuron-specific enolase, Leu-7 [HNK-1], neurofilament 200 kd, and S100) were found in nine of 10 cases of PN and in 17 of 25 cases of ESB. In ESB, an atypical light microscopic appearance correlated with the presence of neuroectodermal features in most cases, but neuroectodermal phenotype was more frequent (68%) than morphological evidence of neuroectodermal differentiation (36%). These data support the concept that ESB and PN are both peripheral primitive neuroectodermal neoplasms, differing only in extent of neuroectodermal phenotype and morphological differentiation.
PRACTICAL APPLICATIONS OF MOLECULAR MARKERS TO TROPICAL AND SUBTROPICAL SPECIES (1998)

Molecular marker techniques continue to be improved in their simplicity of application and cost. This makes them increasingly practical for routine applications to tropical or subtropical species for which very limited research resources are available. The earlier hybridisation based techniques have been largely replaced by methods based upon PCR (eg RAPD, AFLP and SSR). Recent developments suggest that alternatives to electrophoresis for the analysis of PCR products will provide a further major advantage in practical applications of this technology. Important applications include, commercial variety protection, assessment of seed purity, marker assisted plant breeding and the verification of labelling and identity of plants in production and marketing. Recent examples of applications to tropical and subtropical species include studies of mangoes, bananas, papaya, rice and ornamental and forest species.
Fundamentals of Diagnostic Mycology (1999)

The Basics. Morphology and Methods. Some Opportunistic Fungi. Superficial Fungi. The Dermatophytes. Subcutaneous Fungi. Yeasts and Yeastlike Organisms. Systematic Fungi. Appendix A: Answer Key for Assess What You Have Learned. Appendix B: Glossary of Terms, With Pronunciations. Appendix C: Suggested Student Laboratory Schedules. Appendix D: Reagents, Stains, Media, And Methods.
Calibration in laser speckle contrast imaging (2006)

We provided a novel calibration procedure in laser speckle contrast imaging that can efficiently compensate systematic errors in speckle contrast caused by speckle/pixel size mismatch and static scatters in the tissue.
Mass Spectrometry-based Quantitative Analysis and Biomarker Discovery (2011)

Mass spectrometry-based quantitative analysis and biomarker discovery using metabolomics approach represent one of the major platforms in clinical fields including for the prognosis or diagnosis, assessment of severity and response to therapy in a number of clinical disease states as well as therapeutic drug monitoring (TDM). This review first summarizes our mass spectrometry-based research strategy and some results on relationship between cysteinyl leukotriene (cysLT), thromboxane (TX), 12-hydroxyeicosatetraenoic acid (12-HETE) and other metabolites of arachidonic acid and diseases such as atopic dermatitis, rheumatoid arthritis and diabetes mellitus. For the purpose of evaluating the role of these metabolites of arachidonic acid in disease status, we have developed sensitive determination methods with simple solid-phase extraction and applied in clinical settings. In addition to these endogenous compounds, using mass spectrometry, we have developed actually applicable quantitative methods for TDM. Representative example was a method of TDM for sirolimus, one of the immunosuppressant agents for a recipient of organ transplant, which requires rigorous monitoring of blood level. As we recognized great potential in mass spectrometry during these researches, we have become interested in metabolomics as the non-targeted analysis of metabolites. Now, established strategy for the metabolomics investigation applies to samples from cells, animals and humans to separate groups based on altered patterns of metabolites in biological fluids and to identify metabolites as potential biomarkers discriminating groups. We would be honored if our research using mass spectrometry would contribute to provide useful information in the field of medical pharmacy.
A Single Channel Approach to High Resolution Direction Finding and Beamforming (2003)

I. ABSTRACT This paper presents an array processing approach that only requires the array outputs to be sampled one at a time by a single channel receiver. We note that the sequential sampling of the array outputs is equivalent to the periodic but non-uniform sampling af the source waveform. The derived array model is structurally similar to the conventional array model. This allows the direct application of most conventional high resolution DOA estimation and heamforming algorithms with the proposed approach. The feasibility of this approach is demonstratcd with simulation data.
Static analysis of XML transformations in java (2004)

XML documents generated dynamically by programs are typically represented as text strings or DOM trees. This is a low-level approach for several reasons: 1) traversing and modifying such structures can be tedious and error prone, 2) although schema languages, e.g., DTD, allow classes of XML documents to be defined, there are generally no automatic mechanisms for statically checking that a program transforms from one class to another as intended. We introduce XACT, a high-level approach for Java using XML templates as a first-class data type with operations for manipulating XML values based on XPath. In addition to an efficient runtime representation, the data type permits static type checking using DTD schemas as types. By specifying schemes for the input and output of a program, our analysis algorithm will statically verify that valid input data is always transformed into valid output data and that the operations are used consistently.
Analysis of Next Generation TCP (2004)

The Transmission Control Protocol (TCP) has been around for around 30 years, and in that time computer networks have increased in speed and reliability many times over. TCP has done very well to maintain stability and avoid collapse from congestion in the Internet with this incredible increase in speed. But as the speed of networks continues to increase, some assumptions about the underlying network that influenced the design of TCP may no longer hold valid. Additionally, modern networks often span many different types of links. For example, one end-to-end transmission may traverse both an optical link (high-bandwidth, low-loss) and a wireless network (low-bandwidth, high loss). TCP does not perform well in these situations. This survey will examine some of the reasons for this, focusing on high-bandwidth networks, and offer some solutions that have been proposed to fix these problems. This paper assumes basic knowledge of the TCP protocol.
Topical tretinoin or adapalene in acne vulgaris: an overview (2004)

Retinoids target several pathoetiologic events of acne vulgaris. The undisputed efficacy of tretinoin, and yet its underutilization, due to apprehension of retinoid dermatitis, triggered a search for newer, well-tolerated retinoids. The discovery of nuclear retinoic acid receptors has provided clues to a rational design of synthetic, receptor-selective retinoic acid agonists. Adapalene is an addition to the arsenal of topical retinoids. It possesses the biological properties of tretinoin, but has a distinct physiochemical profile, including high lipophilicity and increased chemical and photostability. It exhibits selective affinity for nuclear retinoic acid receptors and does not bind to cytosolic retinoic acid binding proteins. It exemplifies the formulation of a novel retinoid with specific pharmacologic profile and clinical objectives. Accordingly, numerous clinical trials have compared adapalene and tretinoin in the management of acne vulgaris and concluded that tretinoin 0.05% gel exhibits a greater anti-acne efficacy than adapalene 0.1% gel, but has higher skin irritation potential. This article reviews the pharmacology of adapalene, including its retinoid receptor binding profile, antiproliferative effects, cell differentiation modulation, comedolytic and anti-inflammatory activity, and specifically focuses on the comparison of the efficacy and irritation profile of adapalene and tretinoin.
Notes on the Ring and Ball Method (1931)

This is a method used in measuring the softening point of a bituminous material. In fact, it has been adopted as standard by the American Society for Testing Materials. Recently Walker has discussed this test and suggested a more convenient form of apparatus.
Low Molecular Weight Peptides Restore the Procoagulant Activity of Factor VIII in the Presence of the Potent Inhibitor Antibody ESH8 (2002)

Following repeated administration of factor VIII (FVIII), a significant number of hemophilia A patients develop antibodies (Abs), inhibiting the procoagulant activity of infused FVIII. We have designed an approach based on the blocking of the deleterious activity of these Abs by peptide decoys mimicking the anti-FVIII Ab epitopes. Here, the well characterized inhibitory monoclonal Ab ESH8 served as a model. Several phage peptide libraries were screened for specific binding to ESH8. Seven constrained dodecapeptide sequences were obtained. Six sequences carried the consensus motif, hydrophobic-(Y/F)GKTXL. This motif showed a certain similarity with the (2231)QVDFQKTMKV(2240) sequence of the C(2) domain. In the seventh sequence, YCNPSIGDKNCR, the residues GDKN are similar to the sequence (2267)DGHQ(2270). Upon inspection of the C(2) domain crystallographic structure, the two stretches QVDFQKTMKV and DGHQ appeared close together in space and might constitute a discontinuous epitope. Corresponding synthetic peptides were able to inhibit the binding of ESH8 to FVIII in a specific and dose-dependent manner. Moreover, the ability of the selected peptides to neutralize the inhibitory activity of ESH8 was demonstrated in functional tests as well as in vivo in a murine model of hemophilia A. This study demonstrates the potential of this approach to neutralize the activity of potent inhibitory Abs.
How Is Maternal Nutrition Related to Preterm Birth? (2011)

The incidence of preterm birth in developed countries is increasing, and in some countries, including the United States, it is almost as high as in developing countries. Demographic changes in women becoming pregnant can account for only a relatively small proportion of the increase. A significant proportion of spontaneous preterm birth continues to be of unknown cause. Experimental data from animal studies suggesting that maternal undernutrition may play a role in spontaneous, noninfectious, preterm birth are supported by observational data in human populations, which support a role for maternal prepregnancy nutritional status in determining gestation length. In addition, intakes or lack of specific nutrients during pregnancy may influence gestation length and thus the risk of preterm birth. As yet, the role of paternal nutrition in contributing to gestation length is unexplored.
Two commercial test kits for CK-MM isoforms evaluated for early recognition of acute myocardial infarction. (1989)

Journal Article Two commercial test kits for CK-MM isoforms evaluated for early recognition of acute myocardial infarction. Get access V D Shah, V D Shah International Immunoassay Labs., Inc., Santa Clara, CA 95054 Search for other works by this author on: Oxford Academic Google Scholar S E Yen, S E Yen International Immunoassay Labs., Inc., Santa Clara, CA 95054 Search for other works by this author on: Oxford Academic Google Scholar A F Diorio, A F Diorio International Immunoassay Labs., Inc., Santa Clara, CA 95054 Search for other works by this author on: Oxford Academic Google Scholar P A Hammer P A Hammer International Immunoassay Labs., Inc., Santa Clara, CA 95054 Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 35, Issue 3, 1 March 1989, Pages 493–494, https://doi.org/10.1093/clinchem/35.3.493a Published: 01 March 1989
Sigma Receptors and Sigma Ligands: Background to a Pharmacological Enigma (2004)

Although it is now well established that the sigma receptors are distinct from neurotransmitter, neuropeptide and steroid receptors, their precise physiological role, and possible involvement in the pathology of neurological and psychiatric disorders, remains an enigma. The purpose of this short review is to provide a basis upon which to explain the pharmacological properties of such a diverse group of drugs as the antidepressants, antipsychotics and neuroprotective agents. However, a greater understanding of the importance of the sigma receptors will depend on the development of more potent and selective sigma agonists and antagonists if the therapeutic potential of the sigma receptors is to be fully realised.
Surface Plasmon assisted extraordinary transmission in metallic nanohole arrays and its suitability as a bio-sensor (2011)

In this work plasmonic nanostructures in the form of free standing films of sub-wavelength holes are fabricated and characterised using a variety of methods. It is shown how the light transmitted through a nanohole array is altered by the dielectric constant of the medium above the array facilitating the development of new types of plasmonic and photonic devices for future bio-sensing applications.
Reference Values for the Augmentation Index and Pulse Pressure in Apparently Healthy Korean Subjects (2010)

Pending validation in prospective outcome-based studies, a peripheral PP of 70 mmHg, central PP of 50 mmHg, peripheral AI of 100%, and central AI of 40% may be preliminary values in adult subjects.
Ticket-based secure delegation service supporting multiple domain models (2002)

We propose a ticket-based delegation service for multiple domain models. This scheme presents an extension to the Kerberos (J.T. Kohl et al., 1991) framework using public key cryptosystem (T. ElGamal, 1985). This proposed model, based on CORBAsec (A. Alireza et al., 2000; B. Blakey, 2000), supports the protection of the high-level resources and the preservation of the security policies of the underlying resources that form the foundation of various domains, between the Kerberized domains and the nonKerberized domains. Also we achieved the flexibility of key management and reliable session key generation between the client and the provider using the public key cryptosystem based ticket.
Cumulative Damage Models for Failure with Several Accelerating Variables (2007)

In this paper, we present a method for incorporating several accelerating variables into accelerated test models for failure of materials. We propose a hyper-cuboidal volume approach as an overall accelerating measure, which enables one to extend existing models for one accelerating variable to the case of several. In particular, we extend a general cumulative damage model and the power-law Weibull model for materials failure to the several accelerating variables case. A real-data example is presented, which illustrates the improvement of the proposed methods over existing models.
Surface Modification of Nanoclays by Catalytically Active Transition Metal Ions (2007)

A unique class of nanoclays was prepared by modification of pristine clays or organoclays (Cloisite C20A) with transition metal ions (TMIs). The composition, structure, morphology and thermal properties of TMI-modified nanoclays were investigated by atomic absorption spectroscopy (AAS), elemental analysis (EA), scanning electron microscopy (SEM), small-angle X-ray scattering (SAXS), wide-angle X-ray diffraction (WAXD), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC) and X-ray absorption near-edge structure (XANES) spectroscopy. The content of TMIs in modified clays was found to be close to the limiting value of ion exchange capacity. SEM and X-ray results confirmed that TMIs were located between the mineral layers instead of being adsorbed on the surface of clay particles. TGA results indicated that the TMI treatment of organoclays could significantly increase the thermal stability, which was more pronounced in air than in nitrogen. Temperature-resolved SAXS measurements revealed that the presence of TMIs increased the onset temperature of structural degradation. The higher thermal stability of TMI-modified organoclays can be attributed to the change in the thermal degradation mechanism, resulting in a decrease in the yield of volatile products and the formation of char facilitated by the presence of catalytically active TMIs.