gebhart/patrepeval huggingface dataset:
Laminin receptor specific therapeutic gold nanoparticles ( <sup>198</sup> AuNP-EGCg) show efficacy in treating prostate cancer (2012)

Systemic delivery of therapeutic agents to solid tumors is hindered by vascular and interstitial barriers. We hypothesized that prostate tumor specific epigallocatechin-gallate (EGCg) functionalized radioactive gold nanoparticles, when delivered intratumorally (IT), would circumvent transport barriers, resulting in targeted delivery of therapeutic payloads. The results described herein support our hypothesis. We report the development of inherently therapeutic gold nanoparticles derived from the Au-198 isotope; the range of the (198)Au β-particle (approximately 11 mm in tissue or approximately 1100 cell diameters) is sufficiently long to provide cross-fire effects of a radiation dose delivered to cells within the prostate gland and short enough to minimize the radiation dose to critical tissues near the periphery of the capsule. The formulation of biocompatible (198)AuNPs utilizes the redox chemistry of prostate tumor specific phytochemical EGCg as it converts gold salt into gold nanoparticles and also selectively binds with excellent affinity to Laminin67R receptors, which are over expressed in prostate tumor cells. Pharmacokinetic studies in PC-3 xenograft SCID mice showed approximately 72% retention of (198)AuNP-EGCg in tumors 24 h after intratumoral administration. Therapeutic studies showed 80% reduction of tumor volumes after 28 d demonstrating significant inhibition of tumor growth compared to controls. This innovative nanotechnological approach serves as a basis for designing biocompatible target specific antineoplastic agents. This novel intratumorally injectable (198)AuNP-EGCg nanotherapeutic agent may provide significant advances in oncology for use as an effective treatment for prostate and other solid tumors.
A piezoelectric power harvester with adjustable frequency through axial preloads (2007)

We study the technique to adjust the performance of a piezoelectric bimorph vibrating in the flexural mode through axial preloads, which is useful for a power harvester to effectively scavenge energy from ambient mechanical vibrations/noise with varying-frequency spectra. The external circuit connected to the bimorph is simplified as an impedance in the analysis. Analytical solutions are derived. The analyses show that resonance happens when the natural frequency of the bimorph is adjusted adjacent to the external driving frequency by preloading, and the output power density can be raised many more times in that case. The mechanism for an axial preload to improve the bimorph performance at varying-frequency vibrations is examined in detail.
cis-Diamineplatinum(II) complexes containing phosphono carboxylate ligands as antitumor agents (1990)

A series of platinum complexes of the form cis-M[PtA2(PC)] (I) has been prepared and tested for antitumor activity in mice. Compounds in this series contain either two monodentate amine ligands (A), such as NH3 or isopropylamine, or one bidentate diamine (A2), such as ethylenediamine, 1,2-diaminopropane, or 1,2-diaminocyclohexane. The PC ligand is a bidentate, O-bound, phosphono carboxylate chelate of the form -O2C(CR1R2)nPO3-, where n = 0 or 1 and R1 and R2 are chosen from H, methyl, ethyl, propyl, butyl, phenyl, or pentanoic acid substituents. The resulting complexes (I) were prepared as the free acids (M = H) or as sodium salts (M = Na). Members of this series have demonstrated good activity in a number of tumor screens. A total of 18 platinum-phosphono carboxylate (Pt-PC) complexes were tested against Sarcoma 180 ascites (S180a) in CFW mice, with 13 analogues showing activity above the 50% ILS level. Antitumor activity was also observed vs L1210 leukemia in CDF1 mice, where six of the 12 compounds tested gave ILS values in the 60-160% range, and vs M5076 reticulum cell sarcoma (sc tumor, iv drug), where four of the four compounds tested gave ILS and T-C values comparable to that of cisplatin. Each of the Pt-PC complexes was characterized by NMR (195Pt, 13C, and 31P), HPLC, and elemental analysis. These compounds, which are anionic at neutral pH, display excellent solubility and stability in aqueous media, such as phosphate-buffered saline and fetal calf serum. On the basis of a comparative study of BUN and serum creatinine levels in treated mice, representative complexes from this series are also less kidney toxic than cisplatin. The results of these studies demonstrate that the platinum-phosphono carboxylate complexes are a promising new class of antitumor agents.
The Control of Neutrophil Chemotaxis by Inhibitors of Cathepsin G and Chymotrypsin (1995)

Neutrophil chemotaxis plays an important role in the inflammatory response and when excessive or persistent may augment tissue damage. The effects of inhibitors indicated the involvement of one or more serine proteinases in human neutrophil migration and shape change in response to a chemoattractant. Monospecific antibodies, chloromethylketone inhibitors, and reactive-site mutants of alpha 1-antitrypsin and alpha 1-antichymotrypsin were used to probe the specificity of the proteinases involved in chemotaxis. Antibodies specific for cathepsin G inhibited chemotaxis. Moreover, rapid inhibitors of cathepsin G and alpha-chymotrypsin suppressed neutrophil chemotaxis to the chemoattractants N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) and zymosan-activated serum in multiple blind well assays and to fMLP in migration assays under agarose. The concentrations of antichymotrypsin mutants that reduced chemotaxis by 50% would inactivate free cathepsin G with a half-life of 1.5-3 s, whereas the concentrations of chloromethylketones required to produce a similar inhibition of chemotaxis would inactivate cathepsin G with a half-life of 345 s. These data suggest different modes of action for these two classes of inhibitors. Indeed the chloromethylketone inhibitors of cathepsin G (Z-Gly-Leu-Phe-CMK) and to a lesser extent of chymotrypsin (Cbz-Gly-Gly-Phe-CMK) mediated their effect by preventing a shape change in the purified neutrophils exposed to fMLP. Antichymotrypsin did not affect shape change in response to fMLP even at concentrations that were able to reduce neutrophil chemotaxis by 50%. These results support the involvement of cell surface proteinases in the control of cell migration and show that antichymotrypsin and chloromethylketones have differing modes of action. This opens the possibility for the rational design of anti-inflammatory agents targeted at neutrophil membrane enzymes.
Research and Application of Improved Apriori Algorithm to Electronic Commerce (2012)

In order to analyze the shopping habits of consumers and more accurately mine the characteristics of consumption, we hereby have proposed and proved Theorem 1-3 to improve the classical Apriori algorithm, resulting in the reduction of database access. We improved the efficiency in the frequent-item sets-based establishment of strong association rule. With this new design we fulfilled the timely recommendation of related products to customers, reflecting the principle of personalized service in e-shopping.
Complement receptor mediates enhanced flavivirus replication in macrophages. (1983)

Evidence is presented that M phi complement receptors (CR3) mediate IgM-dependent enhancement of flavivirus replication in the presence of complement. Enhancement is blocked by pretreatment of macrophages with monoclonal antibody Ml/70, which inhibits CR3 binding, but not by pretreatment with monoclonal antibody 2.4G2, which inhibits FcR binding.
Refractive index study of AlxGa1−xN films grown on sapphire substrates (2003)

A prism coupling method was used to measure the ordinary (no) and extraordinary (ne) refractive indices of AlxGa1−xN films, grown by hydride vapor phase epitaxy (HVPE) and metalorganic chemical vapor deposition (MOCVD) on sapphire, at several discrete wavelengths from 442 nm to 1064 nm. In addition, spectroscopic transmittance and reflectance, correlated with the prism coupling results, were used to measure no as a continuous function of wavelength between the band gap of each sample (255 nm to 364 nm, depending on Al fraction) and 2500 nm. The Al mole fractions (x), determined by energy dispersive x-ray spectroscopy (EDS), were x=0.144, 0.234, 0.279, 0.363, 0.593, and 0.657 for the HVPE-grown samples, and x=0.000, 0.419, 0.507, 0.618, 0.660, and 0.666 for the MOCVD-grown samples. The maximum standard uncertainty in the EDS-determined value of x was ±0.02. The maximum standard uncertainty in the refractive indices measured by prism coupling was ±0.005 and a one-Sellmeier-term equation was adequate to fit the wavelength dependence of ne from 442 nm to 1064 nm. Due to the spectral proximity of the absorption edge, the wavelength dependence of no measured by spectroscopic transmittance/reflectance (correlated with the prism-coupling results), from the band gap of each sample to 2500 nm, was fit with a two-Sellmeier-term equation.
Surface profilometry by a holographic confocal microscopy (2003)

Optica Applicata, Vol. 33, 2003, nr 2-3, s. 381-389
Abstracting People's Trajectories for Social Robots to Proactively Approach Customers (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> For a robot providing services to people in a public space such as a shopping mall, it is important to distinguish potential customers, such as window shoppers, from other people, such as busy commuters. In this paper, we present a series of abstraction techniques for people's trajectories and a service framework for using these techniques in a social robot, which enables a designer to make the robot proactively approach customers by only providing information about target local behavior. We placed a ubiquitous sensor network consisting of six laser range finders in a shopping arcade. The system tracks people's positions as well as their local behaviors, such as fast walking, idle walking, wandering, or stopping. We accumulated people's trajectories for a week, applying a clustering technique to the accumulated trajectories to extract information about the use of space and people's typical global behaviors. This information enables the robot to target its services to people who are walking idly or stopping. The robot anticipates both the areas in which people are likely to perform these behaviors as well as the probable local behaviors of individuals a few seconds in the future. In a field experiment, we demonstrate that this service framework enables the robot to serve people efficiently. </para>
A REMOTE BRIDGE HEALTH MONITORING SYSTEM USING COMPUTATIONAL SIMULATION AND GPS SENSOR DATA. (2003)

In 2001, The University of Nottingham was awarded a three year research grant from the UK’s Engineering and Physical Sciences Research Council. The grant, entitled “A Remote Bridge Health Monitoring System Using Computational Simulation and GPS Sensor Data” is collaborative effort with Cranfield University, Railtrack, W S Atkins and Pell Freischman. The work expands and carries forward previous work started at the University of Nottingham in 1994. The work focuses on using kinematic GPS to create and validate finite element models of bridges, allowing the deflections and vibrations of the structures to be analysed for any uncharacteristic movements. The following paper details the progress of the work to date, including the way in which the field data gathered and analysed by the Nottingham group is used by the Cranfied Group in order to assess the quality of structures. In addition, the use of a Cyrax laser scanner to create a finite element model of a bridge is discussed.
A Descriptive Model of Robot Team and the Dynamic Evolution of Robot Team Cooperation (2005)

At present, the research on robot team cooperation is still in qualitative analysis phase and lacks the description model that can quantitatively describe the dynamical evolution of team cooperative relationships with constantly changeable task demand in Multi-robot field. First this paper whole and static describes organization model HWROM of robot team, then uses Markov course and Bayesian theorem for reference, dynamical describes the team cooperative relationships building. Finally from cooperative entity layer, ability layer and relative layer we research team formation and cooperative mechanism, and discuss how to optimize relative action sets during the evolution. The dynamic evolution model of robot team and cooperative relationships between robot teams proposed and described in this paper can not only generalize the robot team as a whole, but also depict the dynamic evolving process quantitatively. Users can also make the prediction of the cooperative relationship and the action of the robot team encountering new demands based on this model.
Enhanced backward stimulated Raman scattering by coupling between the forward and backward processes (1999)

Abstract A new scheme of backward Raman scattering, in which coupling between the forward and backward Stokes processes is caused by injecting an additional backward pump field, is demonstrated both experimentally and theoretically. Four wave mixing among the pump and Stokes fields leads to gain enhancement of backward Raman scattering. A factor of gain enhancement of 2 was obtained with injection of a 0.4 mJ seed Stokes and a 5 mJ backward pump wave.
Characterizing and Forecasting User Engagement with In-app Action Graph: A Case Study of Snapchat (2019)

While mobile social apps have become increasingly important in people's daily life, we have limited understanding on what motivates users to engage with these apps. In this paper, we answer the question whether users' in-app activity patterns help inform their future app engagement (e.g., active days in a future time window)? Previous studies on predicting user app engagement mainly focus on various macroscopic features (e.g., time-series of activity frequency), while ignoring fine-grained inter-dependencies between different in-app actions at the microscopic level. Here we propose to formalize individual user's in-app action transition patterns as a temporally evolving action graph, and analyze its characteristics in terms of informing future user engagement. Our analysis suggested that action graphs are able to characterize user behavior patterns and inform future engagement. We derive a number of high-order graph features to capture in-app usage patterns and construct interpretable models for predicting trends of engagement changes and active rates. To further enhance predictive power, we design an end-to-end, multi-channel neural model to encode temporal action graphs, activity sequences, and other macroscopic features. Experiments on predicting user engagement for 150k Snapchat new users over a 28-day period demonstrate the effectiveness of the proposed models. The prediction framework is deployed at Snapchat to deliver real world business insights. Our proposed framework is also general and can be applied to other social app platforms.
Vanadate mimics the effect of stem cell factor on highly purified human erythroid burst-forming units in vitro, but not the effect of erythropoietin. (1992)

When orthovanadate, an inhibitor of protein tyrosine phosphatase activity, was added to highly purified human blood erythroid burst-forming units (BFU-E) a marked increase in the number and size of erythroid bursts was evident at an optimum concentration of 4 microM. Because BFU-E are stimulated by stem cell factor (SCF), interleukin 3 (IL-3), and erythropoietin (EP), this effect could occur through an enhancement of any one of these pathways. However, no effect was observed on human erythroid colony-forming units (CFU-E), indicating that vanadate was not potentiating the effect of EP. The time course of decline in BFU-E, when vanadate was added in vitro on successive days, followed the time course produced by delayed addition of SCF but not IL-3. In addition, vanadate markedly enhanced the effect of an optimal concentration of IL-3, but it could only enhance the effect of SCF when SCF concentrations were less than optimum. These experiments demonstrate that vanadate markedly stimulates the number and size of human BFU-E in vitro and that it mimics the effect of SCF. Vanadate may be acting as a phosphatase inhibitor that potentiates the kinase activity induced by SCF, but elucidation of its specific biochemical effects on these cells awaits further investigation.
Hydrophobic films and their efficiency against moisture transfer. 1. Influence of the film preparation technique (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrophobic films and their efficiency against moisture transfer. 1. Influence of the film preparation techniqueM. Martin-Polo, C. Mauguin, and A. VoilleyCite this: J. Agric. Food Chem. 1992, 40, 3, 407–412Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/jf00015a009https://doi.org/10.1021/jf00015a009research-articleACS PublicationsRequest reuse permissionsArticle Views1053Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modeling and Simulating the Efficiency of Gearboxes and of Planetary Gearboxes (2002)

It is shown how to model and simulate frictional ef- fects present in gearboxes and in planetary gearboxes. This includes modeling of gear wheel stucking and sliding due to Coulomb friction between the gear teeth leading to load torque dependent losses. This allows reliable simulation of, e.g., stick-slip effects in servo drives or gear shifts in automatic gearboxes. It is also discussed how the friction characteristics can be mea- sured in a useful way. The presented models are implemented in Modelica and demonstrated at hand of the simulation of an automatic gearbox.
Association between steroid hormone receptor status and disease-free interval in breast cancer. (1979)

The possibility of an association between steroid hormone receptor status and disease-free interval was examined in 292 patients with breast cancer. Estrogen receptor positivity was associated with a prolonged disease-free interval. This association was independent of age, menopausal status, tumor size, or nodal status. There was no association between the presence or absence of progesterone, androgen, or glucocorticoid receptor and disease-free interval.
Analogue median circuit (1994)

A new analogue median circuit with a very sharp DC transfer characteristic is described. The configuration is based on a multiple-input current comparator and can be generalised to other rank extractors. A prototype has been fabricated in a 2 µm CMOS technology, and experimental results are presented.
Magnetic gores of thin tape insulated by cataphoresis (1950)

SPIRALLY-WOUND insulated magnetic cores of thin tape play an important role in modern communication systems. In the telephone plant, high-frequency transformers are required in connection with the simultaneous transmission of a large number of messages over a single circuit. In radar, transformers developing high-power microsecond pulses having large components of energy at high frequencies are used extensively. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> The trend toward high frequencies forced a reduction in the thickness of core laminations. This was necessary to maintain a high effective permeability and low core loss at the operating frequency. Of course, each lamination must be effectively protected against interlaminar welding during the final heat treatment that is required by all high permeability materials to develop their magnetic properties. This welding, unless prevented, permits eddy currents and sets up mechanical stresses which may impair magnetic properties.
Synthesis and calcium channel modulation effects of isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-phenylpyridine-5-carboxylates possessingortho-,meta-, andpara-CH2S(O)nMe and -S(O)nMe (n = 0-2) phenyl substituents (2000)

A group of isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-phenylpyridine-5-carboxylates (13–15) possessing ortho-, meta-, and para-CH2S(O)nMe and –S(O)nMe (n = 0–2) phenyl substituents were synthesized using a modified Hantzsch reaction. Calcium channel (CC) modulating activities were determined using guinea pig ileum longitudinal smooth muscle (GPILSM) and guinea pig left atrium (GPLA) in vitro assays. This class of –CH2S(O)nMe and –S(O)nMe (n = 0–2) compounds (13–15a–f) exhibited weaker CC antagonist activity on GPILSM (IC50 = > 1.1 × 10–5 to 4.1 × 10–6 M range) than the reference drug nifedipine (IC50 = 1.4 × 10–8 M). The oxidation state of the sulfur atom was a determinant of smooth muscle CC antagonist activity where the relative activity profile was generally thio (13, -CH2SMe, -SMe) and sulfonyl (15, -CH2SO2Me, -SO2Me) > sulfinyl (14, -CH2SOMe, -SOMe). The point of attachment of the phenyl substituent was a determinant of activity for the –CH2SMe (13a–c), -CH2SOMe (14a–c) and SOMe (14d–f) isomers where the relative potency order was meta and para > ortho. Compounds in this group (13–15), unlike Bay K 8644 (EC50 = 2.3 × 10–7 M on GPILSM), did not exhibit an agonist effect on GPILSM. The meta-CH2SMe (13b), ortho-CH2SMe (13c), meta-SMe (13e), and ortho-CH2SO2Me (15c) C-4 phenyl derivatives exhibited respectable in vitro cardiac positive inotropic activities (EC50 = 1.00 × 10–6 to 7.57 × 10–6 M range) relative to the reference drug Bay K 8644 (EC50 = 7.70 × 10–7 M) in the GPLA assay. In contrast to Bay K 8644, which acts as an undesirable calcium channel agonist on smooth muscle (GPILSM), compounds 13b (IC50 = 4.11 × 10–6 M), 13c (IC50 = 2.29 × 10–5 M), 13e (IC50 = > 1.20 × 10–5 M) and 15c (IC50 = 6.22 × 10–6 M) exhibited a desirable simultaneous calcium channel antagonist effect on smooth muscle at a similar (13b, 15c), or lower (13c, 13e), concentration relative to its cardiac agonist EC50 value. Model compounds such as 13b, 13c, 13e, and 15c, that exhibit dual cardioselective agonist / smooth muscle selective antagonist activities, represent a novel type of 1,4-dihydropyridine CC modulators that offer a potential approach to drug discovery targeted toward the treatment of congestive heart failure and for use as probes to study the structure–function relationship of calcium channels. Drug Dev. Res. 51:177–186, 2000. © 2001 Wiley-Liss, Inc.
<i>Helicobacter pylori</i> SabA Adhesin in Persistent Infection and Chronic Inflammation (2002)

Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.