gebhart/patrepeval huggingface dataset:
Clinical evaluation of<i>Lactobacillus paracasei</i>subsp.<i>paracasei</i>F19 with gluco-oligosaccharides in the short-term treatment of irritable bowel syndrome (2009)

Objective: The aim of the present research was to evaluate, in an open, short-term study, the efficacy and tolerability of a probiotic containing Lactobacillus paracasei subsp. paracasei F19 in irritable bowel syndrome (IBS). Patients and methods: Studies were carried out on 100 patients with IBS (38 male, 62 female, age range 18–68 years), 52 with diarrhoea and 48 with constipation, recruited in accordance with the Rome II diagnostic criteria. All patients were administered Genefilus F19 (Siffra Pharmaceuticals SpA, Florence, Italy), a commercial preparation containing L. paracasei subsp. paracasei F19, at a dose of one sachet (dissolved in water) twice daily for 14 days. Each sachet contained 12×109 genetically stable microorganisms of L. paracasei subsp. paracasei F19, combined with 750 mg gluco-oligosaccharides plus vitamins B1, B5 and B6. Symptoms were evaluated, based upon a daily diary, before and after treatment. In addition, in a series of 20 consecutive patients, L. paracasei subsp. paracasei F19 content was evaluated in faeces before and after treatment. Results: Following treatment, abdominal pain was no longer present in 94% of the patients with IBS with diarrhoea or in 87% of those with IBS with constipation. Diarrhoea was no longer present in 88% of the patients, while constipation was no longer present in 83% of the patients. Abdominal distension had disappeared, or considerably improved, in 95% of the study population. These percentages remained practically unchanged at follow-up, 2 weeks after the end of treatment. Tolerability was excellent – no significant side effects or drop-outs were recorded. The results of microbiological evaluations performed on faeces revealed a low microbial L. paracasei subsp. paracasei F19 load before treatment and a marked increase in load following treatment, with a minimum of 2, to a maximum of 10, cfu/g faeces. Conclusions: In this short-term study, Genefilus F19 was confirmed to be efficacious and well tolerated in patients with IBS presenting with diarrhoea or with constipation and, therefore, useful in everyday clinical practice. Double-blind controlled studies, with placebo, including clinical evaluations at medium- and long-term follow-up, are now under way with a larger series of patients to confirm these promising findings.
Amido- and carbamoyl-linked pseudoglyceryl lipids and liposomal dynamics (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmido- and carbamoyl-linked pseudoglyceryl lipids and liposomal dynamicsRobert A. Moss, Jong-Ming Li, and Ann T. KotchevarCite this: Langmuir 1994, 10, 10, 3380–3382Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/la00022a003https://doi.org/10.1021/la00022a003research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Molecular Dynamics Simulation of the Kinetic Reaction of Nickel and Aluminum Nanoparticles (2010)

Abstract : Molecular dynamics simulations are used to simulate the kinetic reaction of nickel (Ni) and aluminum (Al) particles at the nanometer scale. The effect of particle size on reaction time and temperature for separate nanoparticles is considered as a model system for a powder metallurgy system. Coated nanoparticles in the form of Ni-coated Al nanoparticles and Al-coated Ni nanoparticles are also analyzed as a model for nanoparticles embedded within a matrix. The differences in melting temperature and phase change behavior, e.g., the volumetric expansion of Al between Al and Ni is expected to produce differing results for the coated nanoparticle systems. For instance, the volumetric expansion of Al upon melting is expected to produce large tensile stresses and possibly rupture in the Ni shell for Ni-coated Al. Simulation results showed that the sintering time for separate and coated nanoparticles was nearly linearly dependent upon the number of atoms or volume of the sintering nanoparticles. We also found that nanoparticle size and surface energy was an important factor in determining the adiabatic reaction temperature for both systems at nanoparticle sizes of less than 10 nm in diameter.
Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas (2017)

Our study showed that NMI suppressed tumor growth by inhibiting PI3K/AKT, MMP2/MMP9, COX-2/PGE2 signaling pathways and p300-mediated NF-κB acetylation, and predicted a favorable prognosis in human lung adenocarcinomas, suggesting that NMI was a potential tumor suppressor in lung cancer.
Ferroelectric liquid crystal alignment by oblique evaporation of SiO<sub>2</sub> (1991)

Abstract A study of the alignment of a ferroelectric liquid crystal (FLC) on various obliquely deposited silicon oxide substrates is presented. The FLC is further aligned by an electric field >10 V/μm at 10 hz. Improved bistability and full cone-angle switching are achieved for 10 nm small angle depositions set at a glancing angle of 5° to the substrate. Thicker depositions ±30 nm inhibit full cone-angle switching. Flow effects consistent with piezoelectric flow are observed at high electric fields and khz frequencies.
12 mega-pixel, 1,000 fps visible camera with a nanowatt A/D converter at each pixel (2005)

A large format, area array, digital visible light camera was developed based on A/D conversion at each pixel. Production CMOS technology was used in the development of a monolithic front side illuminated photo diode pixel. Each pixel includes a one loop MOSAD, (Multiplexed Oversample A/D) converter, photo diode, and buffered output to support a very large array format operating at high frame rates. MOSAD is a modification of the delta sigma approach to A/D conversion. The 12 megapixel sensor consists of a 4,000X3,000 pixel array capable of up to 1,000 frames per second sample rate. To approximately fit a 35 millimeter optics format, a pixel size of 8.5 μm was selected. There are no operational amplifiers required at the pixel to perform the A/D function, thus allowing a high fill factor. With this pixel size, a 48% fill factor and 38% photo diode area was achieved. A single process run was completed yielding five 8 inch wafers each containing 27 camera die. The single poly, three metal AMIS 0.35 μm CMOS process was used in the fabrication process. Selected die were directly mounted on a specially designed carrier daughter board. Camera support electronics were designed and fabricated to allow sampling of the camera output using commercial standard Camera Link interfacing. Off the shelf 35 Millimeter optics was used to validate imaging capabilities of the sensor. Tests show that the first iteration sensor chip design works to the fundamental requirements and can image.
Crystallization and preliminary X-ray diffraction analysis of full-length spr1814, a response regulator of<i>Streptococcus pneumoniae</i>, in complex with a phosphoryl analogue (2014)

Spr1814 of Streptococcus pneumoniae is a signal transduction response regulator belonging to the NarL/FixJ subfamily, which has a helix-turn-helix DNA-binding effector domain. To understand how the phosphorylation of the conserved aspartic acid residue induces conformational changes in spr1814 allowing binding to the target promoter, recombinant spr1814 expressed in Escherichia coli was crystallized with the phosphoryl analogue beryllium fluoride BeF3(-) by the hanging-drop vapour-diffusion method. The crystals diffracted to 1.9 Å resolution and belonged to space group P21, with unit-cell parameters a = 40.2, b = 114.5, c = 50.1 Å, β = 92.1°. Structure determination by the SAD method using the bromine derivative 5-amino-2,4,6-tribromoisophthalic acid (B3C) is under way.
Biomarkers of progression of chronic obstructive pulmonary disease (COPD). (2014)

Disease progression of chronic obstructive pulmonary disease (COPD) is variable, with some patients having a relatively stable course, while others suffer relentless progression leading to severe breathlessness, frequent acute exacerbations of COPD (AECOPD), respiratory failure and death. Radiological markers such as CT emphysema index, bronchiectasis and coronary artery calcification (CAC) have been linked with increased mortality in COPD patients. Molecular changes in lung tissue reflect alterations in lung pathology that occur with disease progression; however, lung tissue is not routinely accessible. Cell counts (including neutrophils) and mediators in induced sputum have been associated with lung function and risk of exacerbations. Examples of peripheral blood biological markers (biomarkers) include those associated with lung function (reduced CC-16), emphysema severity (increased adiponectin, reduced sRAGE), exacerbations and mortality [increased CRP, fibrinogen, leukocyte count, IL-6, IL-8, and tumor necrosis factor α (TNF-α)] including increased YKL-40 with mortality. Emerging approaches to discovering markers of gene-environment interaction include exhaled breath analysis [volatile organic compounds (VOCs), exhaled breath condensate], cellular and systemic responses to exposure to air pollution, alterations in the lung microbiome, and biomarkers of lung ageing such as telomere length shortening and reduced levels of sirtuins. Overcoming methodological challenges in sampling and quality control will enable more robust yet easily accessible biomarkers to be developed and qualified, in order to optimise personalised medicine in patients with COPD.
A new and greener method to manufacture copolymer-1 (2011)

Polyamino acid random copolymers have a wide variety of properties that mimic proteins, which make these random copolymers suitable for the treatment of certain diseases. For example, polyamino acid random copolymers comprising alanine, glutamic acid, lysine, and tyrosine (copolymer-1) have been used in the treatment of multiple sclerosis. Synthesis of this copolymer requires protecting groups for the side chains of the glutamic acid and lysine residues. The manufacture of copolymer-1 is typically achieved by protecting lysine with N trifluoroacetyl (TFA) and glutamic acid with -benzyl protecting groups respectively.
Avian Pox: Infection and Immunity with Quail, Psittacine, Fowl, and Pigeon Pox Viruses (1985)

Quail, chickens, and turkeys vaccinated with pigeon and fowl pox viruses were not protected against challenge of their immunity with quail pox virus and they developed severe cutaneous lesions of pox. When quail and chickens were vaccinated with quail pox virus and given pigeon and fowl pox challenge viruses, no protection was present. Thus, quail pox virus had no immunologic relationship to pigeon and fowl pox viruses. Psittacine pox virus applied as a vaccine in quail and chickens also failed to protect against quail pox virus challenge. However, quail, chickens, and turkeys vaccinated with quail pox virus were protected against quail pox virus challenge. An isolate of psittacine pox virus, applied as a vaccine, protected chickens against challenge with the same virus isolate and also against challenge with two other psittacine pox virus isolates, confirming a close or identical antigenic relationship with each other. When combined in a multivalent vaccine, quail, psittacine, and fowl pox viruses induced excellent protection in chickens against challenge with the three respective viruses. The presence or absence of "takes" or reactions following vaccination by the wing web route did not necessarily correlate with the presence or absence of immunity noted from challenge by feather follicle virus application. The role of quail and psittacine pox viruses as potential pathogens for poultry was discussed briefly.
A Multivariate Analysis of the Human Development Index (2002)

A multivariate technique called principal component analysis is used to combine measures of human development. The first principal component index is the linear combination of component indexes with maximal information content. This multivariate technique accounts for differences in the variances of component indexes as well as interdependence among the component indexes. The first principal component of the three indexes used in the HDI (life expectancy, education, GDP) yields rankings nearly identical to the HDI itself. We interpret this as theoretical support for the HDI ranking system as a metric of international human development.
Overcoming severe renal ischemia: the role of ex vivo warm perfusion (2002)

Background. The ability to effectively utilize kidneys damaged by severe (2 hr) warm ischemia (WI) could provide increased numbers of kidneys for transplantation. The present study was designed to examine the effect of restoring renal metabolism after severe WI insult during ex vivo warm perfusion using an acellular technology. After warm perfusion for 18 hr, kidneys were reimplanted and evaluated for graft function. Methods. Using a canine autotransplant model, kidneys were exposed to 120 min of WI. They were then either reimplanted immediately, hypothermically machine perfused (4°C) for 18 hr with Belzer’s solution, or transitioned to 18 hr of warm perfusion (32°C) with an acellular perfusate before implantation. Results. Warm perfused kidneys with 120 min of WI provided life-sustaining function after transplantation, whereas the control kidneys immediately reimplanted or with hypothermic machine perfusion did not. The mean peak serum creatinine in the warm perfused kidneys was 3.7 mg/dl, with the mean peak occurring on day 2 and normalizing on day 9 posttransplant. Conclusions. These results indicate that 18 hr of ex vivo warm perfusion of kidneys is feasible. Furthermore, recovery of renal function during warm perfusion is demonstrated, resulting in immediate function after transplantation. The use of ex vivo warm perfusion to recover function in severe ischemically damaged kidneys could provide the basis for increasing the number of transplantable kidneys.
Citicoline improves memory performance in elderly subjects. (1997)

Citicoline is a choline donor involved in the biosynthesis of brain phospholipids and acetylcholine extensively used in the treatment of neurodegenerative diseases. In this study we investigated the effects of the oral administration of citicoline alone (C1000:1000 mg/day; C500:500 mg/day) or in combination with nimodipine (C +NI:300 + 90 mg/day) during 4 weeks on memory performance in elderly subjects with memory deficits and without dementia (N = 24; age = 66.12 +/- 10.78 years; MMS score = 31.69 +/- 2.76). Results indicated that citicoline in comparison with placebo improves memory in free recall tasks, but not in recognition tests. A significant improvement in word recall (5.17 +/- 1.1 vs. 3.95 +/- 1.2 omissions; p < 0.005), immediate object recall (6.5 +/- 1.6 vs. 5.5 +/- 1.2 omission; p < 0.05) and delayed object recall (8.5 +/- 2.1 vs. 6.7 +/- 2.4 omissions; p < 0.005) was observed after citicoline treatment. Similar results were found in the three subgroups of treatment (8 subjects per group), suggesting that citicoline possesses memory-enhancing activity at doses of 300-1000 mg/day. A decrease in systolic blood pressure and minor changes in lymphocyte cell counting were also observed in old subjects after receiving citicoline. These effects are consistent with the vasoregulatory and neuroimmune actions of citicoline and suggest that this compound may improve memory by acting on mechanisms of brain neurotropism and cerebrovascular regulation. According to the present results, showing that citicoline improves memory performance in elderly subjects, we concluded that this molecule is suitable for the treatment of memory deficits in old people.
Chiral polytungstometalates [WM<sub>3</sub>(H<sub>2</sub>O)<sub>2</sub>(XW<sub>9</sub>O<sub>34</sub>)<sub>2</sub>]<sup>12–</sup>(X = M = Zn or Co<sup>II</sup>) and their M-substituted derivatives. Syntheses, chemical, structural and spectroscopic study of some<scp>D</scp>,<scp>L</scp>sodium and potassium salts (1991)

Heteropolyanions [WM3(H2O)2(XW9O34)2]12–(X = M = Zn or CoII) form on ageing concentrated solutions of sodium salts of the well known polyanions [Zn(H2O)(ZnW11O39)]8– and [CoII(H2O)(CoIIW11O39)]8–. Their high-yield syntheses are reported. An X-ray crystallographic study of Na12[WZn3(H2O)2(ZnW9O34)2]·46H2O [Space group p21/c, a= 13.027(4), b= 17.788(5), c= 24.124(4)Å, β= 118.94(2)°, Z= 2, R′= 0.051 for 3783 reflections] and its high-resolution 183W NMR spectrum (ten lines, one with half the intensity of the others) reveal that the polyanion is isotypical of the earlier described [M4(H2O)2(PW9O34)2]10– anions (M = Zn or CoII) and elucidate the puzzling analytical composition Zn5W19. However, the lower point-group symmetry C2 (instead of C2h) points to the existence of enantiomers. This anion and the homologous cobalt(II) anion are always obtained as racemic mixtures. Both parent anions transform into substitution derivatives by replacement of atoms in M positions (Two or three for Zn, two only for Co) by transition elements: derivatives of MnII or MnIII, FeII or FeIII, CoII, NiII, CuII, Zn, PdII, PtII and VIV are reported. The structures of D,L-Na12[WCu3(H2O)2(ZnW9O34)2]·48H2O and D,L-K12[WZnV2O2(ZnW9O34)2]·30H2O are also described and compared. Chemical features, comparative electronic UV–VIS spectra, and 183W NMR spectra of these series are discussed.
High Efficiency Electrochemical Reduction of Carbon Dioxide under High Pressure on a Gas Diffusion Electrode Containing Pt Catalysts (1995)

Effects of current density, pressure, and charge passed on the electrochemical reduction of gas phase under high pressure (< 50 atm) on a gas diffusion electrode containing Pt electrocatalysts were investigated. The faradaic efficiency for reduction reached 46% at a current density of . Methane was produced at a faradaic efficiency of 35%. A partial current density of was achieved for methane formation. Ethanol was also produced at a faradaic efficiency of 2.2% (partial current density of ). The faradaic efficiency for methane formation increased with increasing pressure, whereas that for hydrogen formation decreased.
Effects of different environment on combined injury with craniocerebral firearm wound in dogs immersed by seawater (2008)

Objective To investigate effects of different environment of land and sea on combined injury with craniocerebral firearm wound ( CICFW) in dogs immersed by seawater. Methods The model of CICFW including craniocerebral firearm injury,open chest injury, open abdominal injury and burn. The dogs with CICFW were randomly divided into three groups, each of which had 10 dogs; the group Ⅰ(without seawater immersion in land environment) , the group Ⅱ(with seawater immersion in land environment) , and the group Ⅲ( with seawater immersion on sea environment). The changes of vital signs including body temperature, respiration, heart rates and mean arterial pressure were recorded by powlab/8sp electrophysiolograph. The blood gas analysis and electrolytes changes were, monitored. Results The state of an injury was severer in group Ⅲ than that in groupⅠand groupⅡ. Compared with groupⅠand groupⅡ, the respiration and heart rates in group Ⅲ were significantly faster ( P < 0.05). In addition, recirculating system and body heat regulation function were failure in group Ⅲ, as well as low temperature, high plasma osmotic pressure, hypsi-sodium, hyperchloraemia and metabolic acidosis were also vital sign of group El, which of all above them made live time of animals shorten and mortality rate increase. Conclusions The sea environment is one of important influence factors that cause the changes of vital signs and biochemical indicator after CICFW.

Key words: 
Combined injury;  Craniocerebral firearm wound;  Open chest injury;  Open abdominal injury;  Burn;  Seawater immersion;  Animal model
A new mandate for energy conversion: zero emission (electric) vehicles (2003)

Current laws require the sale of zero emission vehicles in several states, as early as 1998. This has caused the automotive industry to focus efforts on the development of battery-powered electric vehicles. As a major part of this effort, a cooperative program for the development of advanced batteries has been undertaken by the automotive industry, the electric power industry, and the US Department of Energy. The vehicle for the effort is the United States Advanced Battery Consortium. The author discusses the goals of the consortium and some of the technological options for meeting those goals, including opportunities for the development of high-performance, cost-effective electrochemical systems. Some of the battery systems that may meet most or all of the goals and are closer to production than other related candidates are briefly reviewed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Maintenance of Adult Stem Cells: Role of the Stem Cell Niche (2011)

Self-renewing stem cells are maintained in functionally specific microenvironments that are termed niches. Optimum combination of intrinsic programs and extrinsic stimuli from niches is essential for maintaining stem cell quiescence and for proper mobilization and differentiation. The most advanced imaging technologies allow the clearer real-time visualization of the behavior of hematopoietic stem cells in living animal. Functions of niche factors, such as adhesion molecules and cytokines, are well studied. Concentration levels of local oxygen and reactive oxygen species also affect the fate of stem cells in their niches. Analysis of niche regulation will lead to a better understanding of stem cell behavior. Moreover, altering the cancer stem cell fate through modification of the niche regulation may be one of the candidates for new therapeutic strategies for diseases such as chemoresistant leukemia.
The doctor in the Industrial Revolution. (1971)

Leeds, the home of both Baker and Charles Turner Thackrah, as 'the cradle of industrial medicine'.' Leeds was doubtless unique in nurturing two such eminent practitioners of this branch of medicine, but many of the other expanding towns of the late 18th and early 19th centuries could claim to be the dwelling place of doctors keenly interested, if not in industrial medicine, at least in social medicine, in the application of their professional skills and know- ledge to the problems of an industrializing and urbanizing society.
Unexpected Abrupt Increase in Left Ventricular Assist Device Thrombosis (2013)

The rate of pump thrombosis related to the use of the HeartMate II has been increasing at our centers and is associated with substantial morbidity and mortality.