gebhart/patrepeval huggingface dataset:
Chemical synthesis of the 1,2,4-triazole nucleosides related to uridine, 2'-deoxyuridine, thymidine, and cytidine (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical synthesis of the 1,2,4-triazole nucleosides related to uridine, 2'-deoxyuridine, thymidine, and cytidineJoseph T. Witkowski and Roland K. RobinsCite this: J. Org. Chem. 1970, 35, 8, 2635–2641Publication Date (Print):August 1, 1970Publication History Published online1 May 2002Published inissue 1 August 1970https://pubs.acs.org/doi/10.1021/jo00833a033https://doi.org/10.1021/jo00833a033research-articleACS PublicationsRequest reuse permissionsArticle Views567Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Scaling Laws for Cavitation Erosion. (1971)

Abstract : In the report, six scaling laws are derived and used to investigate the feasibility of modeling cavitation erosion. The velocity scale and size scale are studied with regard to six nondimensional ratios, namely. the erosion number, the relative nuclei size, the Weber number, the cavitation number, the cavitation inception number and the degree of cavitation. These scaling laws indicate that it is possible to model erosion in the laboratory and to predict the prototype performance. In addition, these scaling laws may be used to explain many currently available experimental observations.
Acute Exacerbations of Chronic Obstructive Pulmonary Disease Are Accompanied by Elevations of Plasma Fibrinogen and Serum IL-6 Levels (2000)

Plasma fibrinogen levels were elevated in stable patients with COPD and may contribute to the increased cardiovascular morbidity and mortality in these patients. COPD exacerbations increased serum IL-6 levels, leading to a rise in plasma fibrinogen. Thus acute rather than chronic infection may have a role in predisposing to coronary heart disease or stroke.
Adaptive Transceiver Design for C-RAN in mmWave Communications (2017)

An adaptive array design is proposed for hybrid beamforming in millimeter-wave (mmWave) communications in the context of cloud radio access networks (C-RAN). More explicitly, the adaptive design focuses on the physical layer aspect of C-RAN. The adaptation is performed at two levels, depending on whether the channel is of line-of-sight (LOS) or non-line-of-sight (NLOS) nature. First, the antenna array architecture can be adapted between a fully connected and a sub-array-connected architecture. Then, the employment of a digital precoder in the baseband is decided based on both the channel conditions and the architecture employed. We show that the proposed adaptive design performs better than the fully connected and sub-array-connected constituent designs, when the channel varies between LOS and NLOS scenarios. Then, we extend our proposed adaptive design to mmWave communications in the context of C-RAN, where we propose an adaptive virtual cell formation algorithm, where a user can be connected to one or two remote radio heads, depending on the channel conditions.
Halothane inhibits the neurotoxin stimulated [<sup>14</sup>C]guanidinium influx through ‘silent’ sodium channels in rat glioma C<sub>6</sub> cells (1985)

We have investigated the effect of pharmacological agents on [14C]guanidinium ion influx through sodium channels in C6 rat glioma and N18 mouse neuroblastoma cells. The sodium channels of the N18 cells can be activated by aconitine alone, indicating that they are voltage-dependent channels. In contrast, sodium channels in the C6 cells require the synergistic action of aconitine and scorpion toxin for activation and are therefore characterized as so-called silent channels. The general anesthetic halothane used at clinical concentrations, specifically inhibited the ion flux through the silent sodium channel of C6 rat glioma cells. The voltage-dependent channels of the N18 cells were insensitive to halothane at the concentrations tested.
Reactivity of Grubbs' Catalysts with Urea- and Amide-Substituted Olefins. Metathesis and Isomerization (2005)

[Chemical reaction: see text] The reactions of a series of urea- and amide-substituted olefins with Grubbs' catalysts are presented. Depending on the substrate's nature, the formation of either cross-metathesis or isomerization products is observed. To favor the cross-metathesis products, the reactions have been carried out using a wide range of experimental conditions. Upon addition of monophenyl phosphoester to these reactions, the isomerization of the olefins is completely suppressed and the cross-metathesis products are obtained in up to 60% yield.
Molecularly imprinted polyacrylic acid containing multiple recognition sites for steroids (2001)

The preparation and evaluation of a molecularly imprinted polymer (MIP) based on acrylic acid and ethylene glycol dimethacrylate containing multiple recognition sites for steroids is discussed. The ability of the polymer to bind simultaneously three steroids, namely cholesterol, testosterone, and hydrocortisone, is demonstrated. These types of novel MIPs with multiple binding sites could be useful in the design of sensing elements capable of detecting more components at a time. Such polymers could also be used as stationary phases in chromatography with broad separation potential as well as sorbents in solid-phase extraction. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 82: 889–893, 2001
The design and implementation of a database for human genome research (2002)

The Human Genome Project poses severe challenges in database design and implementation. These include comprehensive coverage of diverse data domains and user constituencies; robustness in the presence of incomplete, inconsistent and multi-version data; accessibility through many levels of abstraction, and scalability in content and organizational complexity. The paper presents a new data model developed to meet these challenges by the Utah Center for Human Genome Research. The central characteristics are: (i) a high level data model comprising five broadly applicable workflow notions; (ii) representation of those notions as objects in an extended relational model; (iii) expression of working database schemas as meta data in administration tables; (iv) population of the database through tables dependent on the meta data tables; and (v) implementation via a conventional relational database management system. The authors explore two advantages of this approach: the resulting representational flexibility, and the reflective use of meta data to accomplish schema evolution by ordinary updates. Implementation and performance pragmatics of this work are sketched, as well as implications for future database development.
Self-Sensing Actuators in Electrohydraulic Valves (2004)

Self-sensing refers to extracting the position information from the electromagnetic signals instead of from a physical position sensor. Self-sensing actuator has the benefit of significantly reducing hardware effort. In this paper, we investigate self-sensing actuators applied in direct acing proportional valves. The study is based on the configuration of a dual-solenoid actuator where each solenoid provides the independent single direction force. By considering the electrical dynamics of the solenoids and the nonlinear constraint between the two solenoids, an observer for the flux linkages is obtained. The position estimate is then calculated based on the flux linkage estimates. Both simulation and experiments verify the validity of the proposed algorithm.
Synthesis of New Polyphosphonic Acids (2002)

Abstract A general method for the synthesis of new polyphosphonic acids is described. The hexaisopropyl alkane-1,1,n-triphosphonates (n = 4-5) are formed by the reaction of the salt of tetraisopropyl methylenediphosphonate with diisopropyl n-bromoalkanephosphonates (n = 3-4) while the hexaisopropyl alkane-2,2,n-triphosphonates (n = 5-6) are formed by the reaction of the salt of tetraisopropyl ethane-1,1-diphosphonate with diisopropyl n-bromoalkanephosphonates (n = 3-4). The esters are then hydrolyzed with HCl to give the corresponding phosphonic acids. Keywords: Bone FormationPhosphonic AcidsSynthesis
Addition of thalidomide to melphalan and prednisone treatment prolongs survival in multiple myeloma – a retrospective population based study of 1162 patients (2013)

The combination of melphalan and prednisone (MP) has been the standard treatment of multiple myeloma (MM). Since the introduction of novel agents, the clinical outcome in MM has improved. Six randomized prospective studies with thalidomide combined with melphalan and prednisone (MPT) compared to MP have been performed, most of them showing that MPT gives a better response rate and median overall survival (OS). Amongst 1843 MM patients admitted to 15 Swedish centres, we selected all patients treated with MP and MPT in first, second, third or fourth line of therapy, in total 888 patients treated with MP and 274 with MPT. Patients were evaluated for response rate, OS and Time to Next Treatment. Multivariate Cox model analysis was made to adjust for different criteria at time for MM-diagnosis. The median OS from beginning of first line of treatment was 2.2/4.2 yrs after MP/MPT respectively, and in second, third and fourth line of treatment 1.8/2.9, 1.4/1.6 and 1.1/1.9 yrs (P < 0.0001, 0.003, 0.74 and 0.235). The relative risk for death in the MPT group vs. the MP group was 0.61 (95% CI: 0.45-0.84) in first and 0.55 (0.38-0.83), P < 0.01) in second line. Treatment with MPT gave a significantly better OS rate after both first and second line of therapy when compared with treatment with MP only.
Failure of Interferon γ to Induce the Anti-Inflammatory Interleukin 18 Binding Protein in Familial Hemophagocytosis (2010)

Since IL-18 plays a major role in perpetuating hemophagocytosis, the failure of IFNgamma to induce IL-18BP may constitute a fundamental pathogenetic mechanism. Furthermore, increased production of IL-8 and IL-27 appears to be associated with this disease. Such dysregulation of cytokines was also found in the heterozygous parents, providing a novel insight into genotype-phenotype correlation of FHL which may encourage future research of this rare disease.
Adaptive predictive coding for newspaper facsimile (1980)

An adaptive predictive coding method, which efficiently encodes newspaper pages with printed text and screened photographs is presented. This coding technique utilizes two kinds of predictors with different reference picture elements (pels). One is applied to printed text and the other is applied to screened photographs. The Dth previous pel and its neighboring pels age adopted as the reference pels for the photograph predictor, where distance D coincides with the screen period. Comparing the adaptive predictive coding with a typical document facsimile coding, the data compression ratio is improved by about two times for a screened photograph (compression ratio is 5 ∼ 6) and is almost the same or slightly higher for printed text. Computer simulation shows that if a 500-kbits buffer memory is employed, it is possible to transmit most pages, including an extreme case of a 100 percent photograph page, with a 4500-rev/min scanner at a transmission bit rate of 128 kbit/s. For average pages the revolution speed can be raised to 6000 rev/min. Page transmission time of about 5 min in analog facsimile through a 48-kHz band can be reduced to 1.8 min by adopting the digital transmission with a 128-kbit/s data modem and the adaptive predictive coding technique, when the facsimile revolution speed is set at 6000 rev/min.
Dataflow-driven GPU performance projection for multi-kernel transformations (2012)

Applications often have a sequence of parallel operations to be offloaded to graphics processors; each operation can become an individual GPU kernel. Developers typically explore a variety of transformations for each kernel. Furthermore, it is well known that efficient data management is critical in achieving high GPU performance and that fusing multiple kernels into one may greatly improve data locality. Doing so, however, requires transformations across multiple, potentially nested, parallel loops; at the same time, the original code semantics and data dependency must be preserved. Since each kernel may have distinct data access patterns, their combined dataflow can be nontrivial. As a result, the complexity of multi-kernel transformations often leads to significant effort with no guarantee of performance benefits. This paper proposes a dataflow-driven analytical framework to project GPU performance for a sequence of parallel operations. Users need only provide CPU code skeletons for a sequence of parallel loops. The framework can then automatically identify opportunities for multi-kernel transformations and data management. It is also able to project the overall performance without implementing GPU code or using physical hardware.
Glycan and lectin microarrays for glycomics and medicinal applications (2010)

Three different array formats to study a challenging field of glycomics are presented here, based on the use of a panel of immobilized glycan or lectins, and on in silico computational approach. Glycan and lectin arrays are routinely used in combination with other analytical tools to decipher a complex nature of glycan-mediated recognition responsible for signal transduction of a broad range of biological processes. Fundamental aspects of the glycan and lectin array technology are discussed, with the focus on the choice and availability of the biorecognition elements, fabrication protocols, and detection platforms involved. Moreover, practical applications of both technologies especially in the field of clinical diagnostics are provided. The future potential of a complementary in silico array technology to reveal details of the protein-glycan-binding profiles is discussed here.
Innovative Subsurface Remediation (1999)

Groundwater pollution has become one of our most pervasive environmental problems, and remediating sites with contaminated groundwater has proven to be a formidable challenge. Remediation efforts are often limited by the complexity of the subsurface environment, and by our lack of knowledge of that environment. Recent research has focused on enhancing our understanding of the complex subsurface environment and on developing innovative technologies capable of handling these complexities. An important step in the evolution of a new technology is going beyond well-controlled laboratory experiments to testing the technology at the field scale (i.e., real world). The purpose of this volume is to present evaluations of selected innovative technologies that have undergone field demonstration testing. This volume also reports on recent advances in subsurface characterization techniques that are critical to the proper design of all technologies, and that can help assess the performance of these technologies.
<i>Dnmt1</i>Overexpression Causes Genomic Hypermethylation, Loss of Imprinting, and Embryonic Lethality (2002)

Biallelic expression of Igf2 is frequently seen in cancers because Igf2 functions as a survival factor. In many tumors the activation of Igf2 expression has been correlated with de novo methylation of the imprinted region. We have compared the intrinsic susceptibilities of the imprinted region of Igf2 and H19, other imprinted genes, bulk genomic DNA, and repetitive retroviral sequences to Dnmt1 overexpression. At low Dnmt1 methyltransferase levels repetitive retroviral elements were methylated and silenced. The nonmethylated imprinted region of Igf2 and H19 was resistant to methylation at low Dnmt1 levels but became fully methylated when Dnmt1 was overexpressed from a bacterial artificial chromosome transgene. Methylation caused the activation of the silent Igf2 allele in wild-type and Dnmt1 knockout cells, leading to biallelic Igf2 expression. In contrast, the imprinted genes Igf2r, Peg3, Snrpn, and Grf1 were completely resistant to de novo methylation, even when Dnmt1 was overexpressed. Therefore, the intrinsic difference between the imprinted region of Igf2 and H19 and of other imprinted genes to postzygotic de novo methylation may be the molecular basis for the frequently observed de novo methylation and upregulation of Igf2 in neoplastic cells and tumors. Injection of Dnmt1-overexpressing embryonic stem cells in diploid or tetraploid blastocysts resulted in lethality of the embryo, which resembled embryonic lethality caused by Dnmt1 deficiency.
Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model (2012)

We concluded that intravitreous administration of recombinant TSG-6 might stabilize retinal lesions in Ccl2-/-/Cx3cr1-/- mice on rd8 background. Modulation of ocular immunological gene expressions, especially IL-17a, could be one of the mechanisms.
Dynamic Logic Applied to SAR Data for Parameter Estimation Behind Walls (2007)

Identifying and localizing targets within buildings using exterior sensors will offer superior advantages to the military and law enforcement communities. Research on wall-penetrating radar has produced significant advances in recent years regarding this topic. However, wall parameter ambiguities, multiple reflections, clutter, and measurement noise pose significant challenges to developing robust detection and estimation methods. In the present work we demonstrate can be mitigated using dynamic logic (DL), an adaptive method for iterative maximum likelihood.
Automatic Real-Time Barcode Localization in Complex Scenes (2006)

Many applications exist for automatically finding and reading barcodes in complex scenes with a camera. The key problem is to search barcodes in a complex scene and supply them for a reading subsystem. However, illumination, rotation, perspective distortion and multiple barcodes circumstances make barcode localization difficult. By jointly analyzing texture and shape, we propose a realtime barcode localization method that is robust to the above problems. A user only needs to put a barcode in front of a camera at around 15 cm for common Web cameras, and the system then automatically locates and decodes the barcode. This paper only focuses at automatic localization. We will demonstrate the complete system live at the conference.
Male Fertile and Male Sterile Cabbage, Broccoli, and Cauliflower Clubroot Resistant Breeding Lines (1985)

Abstract Clubroot, caused by Plasmodiophora brassicae Wor., is a major disease of crucifers. The pathogen, which is highly mutable, can survive in the soil for many years, and often occurs in mixed races or populations (9). Of the several races that Williams (10) has identified, the most common and virulent one observed world-wide is race 2 (E.C.D. 16/02/31) (3) to which there are limited sources of resistance within the Brassica oleracea L. group. However, a number of cultivars and lines of rutabaga ( B. napus L.) are resistant to P. brassicae race 2 (1). Therefore, in 1974, an interspecific hybridization program was initiated with the purpose of transferring the gene(s) responsible for resistance to P. brassicae race 2, from rutabaga ( B. napus L.) to cabbage ( B. oleracea L. ssp. capitata L.). Recently, we found that dominant genes from rutabaga responsible for resistance to both P. brassicae races 2 and 6 (E.C.D. 16/02/30) were transferred successfully to cabbage (5 and unpublished data). Both resistances were transferred later form resistant BC 3 cabbages (Fig. 1) to broccoli ( B. oleracea L. var. italica Plenck) and to cauliflower ( B. oleracea L. var. bo-trytis L.). The single dominant gene inheritance to race 2 (5) should simplify the production of race 2-resistant F 1 hybrids.
Impaired Tamoxifen Metabolism Reduces Survival in Familial Breast Cancer Patients (2008)

Poor metabolizer status for CYP2D6 predicts worse overall survival in patients with familial breast cancer. Therefore, CYP2D6 inhibitor drugs should not be prescribed concomitantly with tamoxifen. Prospective studies should be undertaken to establish the effect of CYP2D6 status on outcome in familial breast cancer patients treated with tamoxifen.
215. Phthalocyanines. Part IV. Copper phthalocyanines (1934)

C. E. Dent and R. P. Linstead, J. Chem. Soc., 1934, 1027 DOI: 10.1039/JR9340001027
BROADBAND MAGNETIC FIELD TUNING OF OPTICAL MASERS (1963)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Richard L. Fork, C. K. N. Patel; BROADBAND MAGNETIC FIELD TUNING OF OPTICAL MASERS. Appl. Phys. Lett. 1 May 1963; 2 (9): 180–181. https://doi.org/10.1063/1.1753834 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Reviewing polycrystalline mercuric iodide X-ray detectors (2005)

Polycrystalline films of HgI <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , which are used as nuclear radiation detectors, are fabricated by two different methods, either by physical vapor deposition (PVD) or glued with a polymeric binder called also "particle in binder" (PIB). Both types of PVD or PIB detectors are deposited directly on TFT imagers and can be used for X-ray imaging. The present review will concentrate on PVD-poly-HgI <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2 </sub> . However, the main review body will be a summary of the work performed by RTR, HU and Varian. Works by other groups will be mentioned briefly. The PVD process will be explained by reviewing XRD and SEM data. The charge transport properties of the PVD-polycrystalline HgI <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> detectors as they improved with R&D efforts will be shown. The response of these PVD detectors to <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">241</sup> Am and <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">57</sup> Co gamma rays and their X-ray imaging properties such as dark currents, sensitivity, and imaging resolution will be reviewed