gebhart/patrepeval huggingface dataset:
<i>β</i> 1 integrins mediate adherent phenotype of human erythroblastic cell lines after phorbol 12-myristate 13-acetate induction (1995)

We investigated the effects of phorbol ester (phorbol 12-myristate 13-acetate; PMA) treatment on the adhesive behaviour of three erythroleukaemia cell lines: HEL, LAMA-84 and AP217. In the three cell lines PMA induced an increase in expression of a megakaryocytic marker: alpha IIb beta 3 integrin, but did not promote activation of this receptor. Indeed, an antibody specific for the activated form of alpha IIb beta 3 failed to react with the three cell lines. PMA induction led to different adhesive phenotypes depending on the cell line; in fact LAMA-84 and HEL cells became adherent while AP217 cells remained non-adherent. By studying cell surface receptors we found that the major difference between the adherent and the non-adherent cells was the expression of beta 1 integrins. After PMA induction, beta 1 integrin expression was totally abolished in AP217 cells and the amount of beta 1 mRNA was reduced preventing new synthesis of the subunit. In HEL and LAMA-84 cells, PMA treatment did not alter the overall level of beta 1 integrin but induced a new pattern of alpha-subunit expression: up-regulation of alpha 2 and alpha v subunits and down-regulation of alpha 4 and alpha 5 subunits. Function-perturbing antibodies against beta 1, alpha 4, alpha 5, alpha v and alpha 2 reduced adhesion of HEL cells to fibronectin or collagen, whereas antibodies against beta 3 or alpha v beta 3 did not. Our results favour the involvement of beta 1 integrins in PMA-induced adhesion of erythroleukaemia cells.
Design and Development of Efficient Reversible Floating Point Arithmetic Unit (2015)

For calculation or representation of very large or small numbers, large range is essential. These values can be represented using the IEEE-754 standard based floating point arithmetic representation. The paper presents efficient approach towards designing of high speed floating point unit using reversible logic. Programmable reversible logic design is trending as a prospective logic design style for implementation in recent nanotechnology and quantum computing with low impact on circuit heat generation. There are various reversible implementations of logical and arithmetic units have been proposed in the existing research, but very few reversible floating-point designs has been designed. Floating-point operations are used very frequently in nearly all computing disciplines. The analysis of proposed reversible circuit can be done in terms of quantum cost, garbage outputs, constant inputs, power consumption, speed and area.
Isolation and Structural Elucidation of Aroma Constituents Bound as Glycosides from Sage (<i>Salvia </i><i>officinalis</i>) (1998)

Four glycosidic bound flavor precursors, (1S,2R,4R)-1,8-epoxy-p-menthan-2-yl-O-β-d-glucopyranoside, (6R,9R)-3-oxo-α-ionol β-d-glucopyranoside, (6R,9S)-3-oxo-α-ionol β-d-glucopyranoside, and eugenylglucoside, were isolated from the ethanol extract of Dalmatian sage. Their structures were elucidated by spectral methods (NMR and MS). All four compounds are new to the constituents of sage. Keywords: Sage; flavor precursors; monoterpenes; C13 norisoprenoid; Salvia officinalis
Knee cartilage MRI with in situ mechanical loading using prospective motion correction (2013)

The proposed technique enables knee cartilage imaging under in situ mechanical loading with submillimeter spatial resolution devoid of significant motion artifacts and thus appropriate for cartilage volumetry. It has the potential to provide new insight into the biomechanics of the knee and might complement the panoply of diagnostic MR methods for osteoarthritis.
ABC: A better control for manufacturing (1994)

ABC is a generic methodology to improve the quality of manufacturing. It can optimize operation of a single process or an entire factory to meet or exceed product specifications. ABC is based on three nets which continually interact to model processes and to provide local process control and global product optimization. Significant process variables are identified, evaluated, and ranked according to their contributions to product quality. Process performance, which determines product quality, is characterized by a sensitive parameter, the Q-factor, which is used for local control and for global optimization. Real-time response maps capture process behavior and identify current status, improved operating points, and expected improvement in relation to design targets. ABC continually compensates for off-specification manufacturing steps by feedforward-and-feedback corrective actions which keep the product on target. ABC also evaluates and ranks the effects of non-numeric manufacturing variables, such as specific tools and vendors, on product quality. Total quality control can be achieved by optimizing all variables, both sensor-based and non-numeric, which control the product. Some of ABC's capabilities are demonstrated in a multistep fabrication of a semiconductor capacitor in which the electrical properties of the product are optimized by controlling the individual chemical process steps. ABC's capacity to minimize scrap and rework by compensating for out-of-control conditions is demonstrated in this example. A functional subset of ABC currently exists as a menu-driven tool, implemented in APL2® on VM/CMS for mainframe computers and in the C language for workstation platforms: RS/6000 running under AIX® and PS/2® under OS/2®. ABC is available, in the workstation version, as an IBM Program Offering under the name QuMAP™—A Better Control, and is currently used in the semiconductor, pharmaceutical, chemical, and consumer goods industries.
Cu2O Photocathode for Low Bias Photoelectrochemical Water Splitting Enabled by NiFe-Layered Double Hydroxide Co-Catalyst (2016)

Layered double hydroxides (LDHs) are bimetallic hydroxides that currently attract considerable attention as co-catalysts in photoelectrochemical (PEC) systems in view of water splitting under solar light. A wide spectrum of LDHs can be easily prepared on demand by tuning their chemical composition and structural morphology. We describe here the electrochemical growth of NiFe-LDH overlayers on Cu2O electrodes and study their PEC behavior. By using the modified Cu2O/NiFe-LDH electrodes we observe a remarkable seven-fold increase of the photocurrent intensity under an applied voltage as low as -0.2 V vs Ag/AgCl. The origin of such a pronounced effect is the improved electron transfer towards the electrolyte brought by the NiFe-LDH overlayer due to an appropriate energy level alignment. Long-term photostability tests reveal that Cu2O/NiFe-LDH photocathodes show no photocurrent loss after 40 hours of operation under light at -0.2 V vs Ag/AgCl low bias condition. These improved performances make Cu2O/NiFe-LDH a suitable photocathode material for low voltage H2 production. Indeed, after 8 hours of H2 production under -0.2 V vs Ag/AgCl the PEC cell delivers a 78% faradaic efficiency. This unprecedented use of Cu2O/NiFe-LDH as an efficient photocathode opens new perspectives in view of low biasd or self-biased PEC water splitting under sunlight illumination.
Analysis of Lymphocyte Surface Antigen Expression by the Use of Variant Cell Lines (1977)

Distinct cell types arising within the same organism show both qualitative and quantitative differences in the cell-surface molecules they express (Boyse and Old 1969; Schlesinger 1970; Bennett et al. 1972). A paradigmatic example of this are the cells of the lymphoid system, in which a number of molecules specific to cells in various stages of differentiation can be identified immunologically (Boyse and Old 1969; McKenzie and Snell 1975; Trowbridge et al. 1975a; Cantor and Boyse 1975). Since all of the cells of the lymphoid system arise from a common stem cell (Wu et al. 1968), there must exist a network of structural and regulatory genes that interact during lymphocyte differentiation to produce the surface phenotype characteristic of cells in a particular stage along their pathway of differentiation.
Reduced angle-shift infrared bandpass filter coatings (2007)

Infrared optics are often expected to perform over a wide range of angles of incidence, over a selected bandpass. For the best performance, it is often desired that the shift of spectral features, and the splitting between s and p polarizations, be minimized. These issues can be mitigated to a large extent by design, particularly over a narrow range of angles. However, the availability of high index materials throughout a stack design can greatly improve the performance at a given coating thickness, or greatly reduce the overall thickness required to achieve a design. Here we discuss several designs that have been achieved via hydrogenated silicon in multilayers, which demonstrate improved performance at oblique angles of incidence.
DESIGN CONSIDERATIONS FOR PARALLEL GRAPHICS LIBRARIES (1994)

Applications which run on parallel sdpercomputers are often characterized by massive datasets. Converting these vast collections of numbers to visual form has proven to be a powerful aid to comprehension. For a variety of reasons, it may be desirable to provide this visual feedback at rntime. One way to accomplish this is to exploit the available parallelism to perform graphics operations in place. In order to do this, we need appropriate parallel rendering algorithms and library interfaces. This paper provides a tutorial introduction to some of the issues which arise in designing parallel graphics libraries and their underlying rendering algorithms. The focus is on polygon rendering for distributed memory message-passing systems. We illustrate our discussion with examples from PGL, a parallel graphics library which has been developed on the Intel family of parallel systems. Accesion For NTIS CRA&amp;I
High serum erythropoietin levels are normalized during treatment of congestive heart failure with enalapril (1989)

Eighteen patients with dilated cardiomyopathy (three female, mean age 57 years), were treated for 48 weeks with enalapril added to digoxin and diuretic therapy for congestive heart failure of New York Heart Association (NYHA) functional class II (three patients). III (eight patients) and IV (seven patients), respectively. Serum levels of erythropoietin (EPO) were raised at the start (37 +/- 12.8 pmol 1(-1); mean +/- SD) and were normalized during enalapril treatment (17.5 +/- 9.9 pmol 1(-1) at 48 weeks; P less than 0.001). Serum EPO correlated at the start with NYHA functional class (r = 0.68; P less than 0.05). Normalization of elevated serum EPO concentrations during treatment with enalapril paralleled clinical and haemodynamic improvement, and probably reflected relief from renal hypoxia.
Formation and chemical reactivity of carbon fibers prepared by defluorination of graphite fluoride (1994)

Defluorination of graphite fluoride (CFX) by heating to temperatures of 250 to 450 C in chemically reactive environments was studied. This is a new and possibly inexpensive process to produce new carbon-based materials. For example, CF 0.68 fibers, made from P-100 carbon fibers, can be defluorinated in BrH2C-CH = CH-CH2Br (1,4-dibromo-2butene) heated to 370 C, and graphitized to produce fibers with an unusually high modulus and a graphite layer structure that is healed and cross-linked. Conversely, a sulfur-doped, visibly soft carbon fiber was produced by defluorinating CF 0.9 fibers, made from P-25, in sulfur (S) vapor at 370 C and then heating to 660 C in nitrogen (N2). Furthermore, defluorination of the CF 0.68 fibers in bromine (Br2) produced fragile, structurally damaged carbon fibers. Heating these fragile fibers to 1100 C in N2 caused further structural damage, whereas heating to 150 C in bromoform (CHBr3) and then to 1100 C in N2 healed the structural defects. The defluorination product of CFX, tentatively called activated graphite, has the composition and molecular structure of graphite, but is chemically more reactive. Activated graphite is a scavenger of manganese (Mn), and can be intercalated with magnesium (Mg). Also, it can easily collect large amounts of an alloy made from copper (Cu) and type 304 stainless steel to form a composite. Finally, there are indications that activated graphite can wet metals or ceramics, thereby forming stronger composites with them than the pristine carbon fibers can form.
A macromolecular complex of β <sub>2</sub> adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA (2002)

It has been demonstrated previously that both the cystic fibrosis transmembrane conductance regulator (CFTR) and beta(2) adrenergic receptor (beta(2)AR) can bind ezrinradixinmoesin-binding phosphoprotein 50 (EBP50, also referred to as NHERF) through their PDZ motifs. Here, we show that beta(2) is the major adrenergic receptor isoform expressed in airway epithelia and that it colocalizes with CFTR at the apical membrane. beta(2)AR stimulation increases CFTR activity, in airway epithelial cells, that is glybenclamide sensitive. Deletion of the PDZ motif from CFTR uncouples the channel from the receptor both physically and functionally. This uncoupling is specific to the beta(2)AR receptor and does not affect CFTR coupling to other receptors (e.g., adenosine receptor pathway). Biochemical studies demonstrate the existence of a macromolecular complex involving CFTR-EBP50-beta(2)AR through PDZ-based interactions. Assembly of the complex is regulated by PKA-dependent phosphorylation. Deleting the regulatory domain of CFTR abolishes PKA regulation of complex assembly. This report summarizes a macromolecular signaling complex involving CFTR, the implications of which may be relevant to CFTR-dysfunction diseases.
Visualizing non-speech sounds for the deaf (2005)

Sounds constantly occur around us, keeping us aware of our surroundings. People who are deaf have difficulty maintaining an awareness of these ambient sounds. We present an investigation of peripheral, visual displays to help people who are deaf maintain an awareness of sounds in the environment. Our contribution is twofold. First, we present a set of visual design preferences and functional requirements for peripheral visualizations of non-speech audio that will help improve future applications. Visual design preferences include ease of interpretation, glance-ability, and appropriate distractions. Functional requirements include the ability to identify what sound occurred, view a history of displayed sounds, customize the information that is shown, and determine the accuracy of displayed information. Second, we designed, implemented, and evaluated two fully functioning prototypes that embody these preferences and requirements, serving as examples for future designers and furthering progress toward understanding how to best provide peripheral audio awareness for the deaf.
Morphable messaging: efficient support for evolution in distributed applications (2004)

All but the most briefly used systems must evolve as their mission and roles change over time. Evolution in the context of large distributed systems is extraordinarily complex because of the difficulty of upgrading all components simultaneously, and the fact that such systems are often very sensitive to changes in the message formats that underlay their communication. Prior approaches to the problem of implementing changes in a deployed system have relied upon ad-hoc solutions or protocol negotiation to avoid message format mismatches. We present a novel approach that combines message meta-data and dynamic code generation to create a robust messaging system that naturally supports application evolution.
Multi-connectivity functional architectures in 5G (2016)

Future mobile networks need to fulfill stringent requirements on data rates, reliability, and availability. In order to satisfy these requirements, heterogeneous radio access technologies and deployments need to be used. To make efficient use of these technologies, multi-connectivity has been proposed to connect to multiple different technologies simultaneously. In this paper, we discuss different options to connect to multiple radio access points. Each of these options is further detailed, novel functionality required for multi-connectivity is introduced, and expected benefits are explained.
Membrane Permeability and Transport in<i>Mycobacterium tuberculosis</i> (2014)

As in other mycobacterial species, cells of Mycobacterium tuberculosis are covered by a lipid-rich cell wall. What is most striking in the cell wall is the presence of a large amount of mycolic acids, most of which are covalently linked to the underlying arabinogalactan, which in turn is covalently linked to the peptidoglycan. There are significant differences in drug susceptibility among mycobacteria, and some mycobacterial species other than M. tuberculosis are more resistant to some of the traditional antimycobacterial agents. By using the Zimmermann-Rosselet procedure, the permeability of M. chelonae cell wall to small nutrient molecules was estimated. It was assumed that the nutrients cross the cell wall by a simple diffusion process and then are taken up by the active transport systems located in the cytoplasmic membrane. The mechanisms of inducer exclusion and inducer expulsion are found in organisms that use phosphotransferase system (PTS) transport and demonstrate an ordered hierarchy of carbon source utilization, usually headed by glucose. It is possible to measure the relative contributions of the proton and electrochemical gradients to the activated membrane state.
Cross-Modal Interaction Networks for Query-Based Moment Retrieval in Videos (2019)

Query-based moment retrieval aims to localize the most relevant moment in an untrimmed video according to the given natural language query. Existing works often only focus on one aspect of this emerging task, such as the query representation learning, video context modeling or multi-modal fusion, thus fail to develop a comprehensive system for further performance improvement. In this paper, we introduce a novel Cross-Modal Interaction Network (CMIN) to consider multiple crucial factors for this challenging task, including (1) the syntactic structure of natural language queries; (2) long-range semantic dependencies in video context and (3) the sufficient cross-modal interaction. Specifically, we devise a syntactic GCN to leverage the syntactic structure of queries for fine-grained representation learning, propose a multi-head self-attention to capture long-range semantic dependencies from video context, and next employ a multi-stage cross-modal interaction to explore the potential relations of video and query contents. The extensive experiments demonstrate the effectiveness of our proposed method.
Performance of RCP-II (1997)

The rotation counter protocol (RCP) is a token-passing ring protocol that includes a special field called the rotation counter in the token. It is capable of correlating the traffic among various stations and hence providing priority access. Not only is the mean delay of high-priority traffic small and almost constant, but the delay jitter can also be capped. In this respect, RCP can be used to serve synchronous traffic such as voice. By giving voice packets higher-priority access to the network, their real-time requirement can be satisfied in integrated services. In this paper we evaluate the integrated-services performance of RCP in terms of delay, jitter and throughput. Since this protocol can be adapted to the fibre-optic network, its performance is also compared with that of FDDI. Our performance study demonstrates that RCP-II is a potential candidate for high-speed token ring protocols.
Effects of reaction conditions on rates of incorporation of no‐carrier added F‐18 fluoride into several organic compounds (1988)

Abstract Apparent rate constants (fractional incorporation per minute per mole of organic reactant) were determined for reaction of no‐carrier added F‐18 fluoride with several aliphatic and aromatic substrates in acetonitrile or DMSO. No large differences were seen between tetraethylammonium and potassium Kryptofix‐2,2,2 as supporting cation. Three hexose derivatives with triflate or cyclic sulfate leaving groups all gave apparent rate constants (obtained by dividing fractional incorporation by time in minutes and by molar concentration of reactant) near 0.4 at 23° and 5 at 55°. An aliphatic iodide reacted ten times more slowly. Aromatic substrates tested showed a wide range of rate constants from >50 at 23° (isotope exchange in 2,4‐dinitrofluorobenzene) to 0.6 at 134° (p‐nitroacetophenone).
Determination of clenbuterol in bovine tissues and urine by enzyme immunoassay (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of clenbuterol in bovine tissues and urine by enzyme immunoassayGuy. Degand, Anne. Bernes-Duyckaerts, and Guy. Maghuin-RogisterCite this: J. Agric. Food Chem. 1992, 40, 1, 70–75Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/jf00013a014https://doi.org/10.1021/jf00013a014research-articleACS PublicationsRequest reuse permissionsArticle Views461Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Novel Conotoxin Framework with a Helix−Loop−Helix (Cs α/α) Fold (2005)

Venomous predatory animals, such as snakes, spiders, scorpions, sea anemones, and cone snails, produce a variety of highly stable cystine-constrained peptide scaffolds as part of their neurochemical strategy for capturing prey. Here we report a new family of four-cystine, three-loop conotoxins (designated framework 14). Three peptides of this family (flf14a−c) were isolated from the venom of Conus floridanus floridensis, and one (vil14a) was isolated from the venom of Conus villepinii, two worm-hunting Western Atlantic cone snail species. The primary structure for these peptides was determined using Edman degradation sequencing, and their cystine pairing was assessed by limited hydrolysis with a combination of CNBr and chymotrypsin under nonreducing, nonalkylating conditions in combination with MALDI-TOF MS analysis of the resulting peptidic fragments. CD spectra and nanoNMR spectroscopy of these conotoxins directly isolated from the cone snails revealed a highly helical secondary structure for the four conotoxins. Sequence-specific nanoNMR analysis at room temperature revealed a well-defined helix−loop−helix tertiary structure that resembles that of the Cs α/α scorpion toxins κ-hefutoxin, κ-KTx1.3, and Om-toxins, which adopt a stable three-dimensional fold where the two α-helices are linked by the two disulfide bridges. One of these conotoxins (vil14a) has a Lys/Tyr dyad, separated by approximately 6Å, which is a conserved structural feature in K+ channel blockers. The presence of this framework in scorpions and in cone snails indicates a common molecular imprint in the venom of apparently unrelated predatory animals and suggests a common ancestral genetic origin.