gebhart/patrepeval huggingface dataset:
Organoboron Compounds. IX. 8-Quinolineboronic Acid, its Preparation and Influence on Reactions of Chlorohydrins<sup>1</sup> (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganoboron Compounds. IX. 8-Quinolineboronic Acid, its Preparation and Influence on Reactions of Chlorohydrins1Robert L. Letsinger and S. H. DandegaonkerCite this: J. Am. Chem. Soc. 1959, 81, 2, 498–501Publication Date (Print):January 1, 1959Publication History Published online1 May 2002Published inissue 1 January 1959https://pubs.acs.org/doi/10.1021/ja01511a060https://doi.org/10.1021/ja01511a060research-articleACS PublicationsRequest reuse permissionsArticle Views395Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Long-term immunogenicity of a plasma-derived hepatitis B vaccine in HIV seropositive and HIV seronegative hemophiliacs (1989)

• Short-term studies indicate that hepatitis B vaccines are safe and satisfactorily immunogenic in hemophiliacs. The duration of immunity in these immunocompromised patients, however, is not known. To determine this, we studied 78 hemophiliacs prospectively 2, 3, and 4 years after the initial vaccination with a plasma-derived vaccine given as three monthly injections followed by a fourth booster injection at month 14. The duration of immunity clearly depended on whether the patients were infected with the human immunodeficiency virus (HIV). In HIV seronegative hemophiliacs (n = 67), there was a progressive decline in titers of antibody to the hepatitis B surface antigen (anti-HBs), but antibody was still detectable 4 years later in all of them. From the curves of decline of antibody titers, it appears that there is no need to revaccinate patients for at least 5 to 6 years. The HIV seropositive hemophiliacs (n=11) not only started from much lower anti-HBs titers, but 5 of 11 lost anti-HBs. None of the 45 patients treated with concentrates during the postvaccination period developed serologic signs of hepatitis B, even though 6 of them had come into contact with live or inactivated hepatitis B virus as shown by the occurrence of spontaneous anamnestic antibody responses. This vaccine and schedule of vaccination afford a prolonged duration of immunity in HIV seronegative hemophiliacs, but HIV seropositive hemophiliacs have a risk of losing immunity early. (<i>Arch Intern Med.</i>1989;149:1333-1337)
Millimeter Waves from Harmonic Generators (1954)

The process of generating millimeter microwave energy from a crystal multiplier driven by a reflex klystron is discussed. Quantitative data are given on the intensity of the various harmonics down to a wavelength of 1.9 mm. A harmonic generator of novel construction which has proven superior to the previously used types is described, and the details of our version of a built-in crystal detector are given.
Polysaccharase Activity in Streptococcus agalactiae (Group B Streptococci) (1982)

Of 300 recently isolated strains of Streptococcus agalactiae from human sources, 97% degraded starch. Representative strains also degraded glycogen, pullulan, amylopectin and amylose. The polysaccharase activity is easily detected by clearing around growth on Columbia agar base medium. The activity is weaker than that of some S. pyogenes strains, and it does not appear to produce fermentable products but is inhibited by the presence of easily used sugars.
Femtosecond laser bone ablation with a high repetition rate fiber laser source (2014)

Femtosecond laser pulses can be used to perform very precise cutting of material, including biological samples from subcellular organelles to large areas of bone, through plasma-mediated ablation. The use of a kilohertz regenerative amplifier is usually needed to obtain the pulse energy required for ablation. This work investigates a 5 megahertz compact fiber laser for near-video rate imaging and ablation in bone. After optimization of ablation efficiency and reduction in autofluorescence, the system is demonstrated for the in vivo study of bone regeneration. Image-guided creation of a bone defect and longitudinal evaluation of cellular injury response in the defect provides insight into the bone regeneration process.
Simultaneous catalytic elimination of formaldehyde and ozone over one‐dimensional rod‐like manganese dioxide at ambient temperature (2019)

ABSTRACT Background Formaldehyde (HCHO) and ozone (O 3 ) are seriously hazardous materials to human health, especially in the indoor environment, and need to be inhibited. Manganese dioxide (MnO 2 ) catalysts have been extensively studied in the field of environmental pollution owing to their various morphologies and crystal structures. In this study, one‐dimensional rod‐like MnO 2 catalysts were prepared by a hydrothermal method. The crystal form and other factors affecting the activity were explored through an activity test and various characterization methods. The decomposition process of HCHO and O 3 on the most active catalyst was analyzed by in situ diffuse reflection infrared Fourier transform spectroscopy (DRIFTS). Results α ‐MnO 2 displayed the best catalytic performance and achieved 90% HCHO conversion, 100% carbon dioxide (CO 2 ) yield and 100% O 3 decomposition under different experimental conditions. The characterization results illustrated that the crystal phase of α ‐MnO 2 has a suitable tunnel structure for HCHO adsorption, also leading to greater mobility of adsorbed oxygen species, abundant oxygen vacancies and active surface oxygen species, which could be the reason for the superior catalytic performance of α ‐MnO 2 . Formate and dioxymethylene (DOM) species were identified as the dominant intermediates by in situ DRIFTS. The surface hydroxyl (OH) group was confirmed to play an essential role in the complete oxidation of carbonaceous intermediates into harmless CO 2 and water (H 2 O). Conclusion α ‐MnO 2 exhibited the best catalytic performance among the as‐prepared samples and can efficiently eliminate HCHO and O 3 in the environment. © 2019 Society of Chemical Industry
Beam Properties of 980-nm Tapered Lasers With Separate Contacts: Experiments and Simulations (2008)

The beam properties of 980-nm tapered lasers with separate current drives for the ridge waveguide and tapered sections are analyzed by means of a comparison between simulations and experimental results. The simulations are performed with a new model for this type of tapered lasers, providing a good qualitative agreement with experiments. The observed improvement in the beam quality by a stronger pumping of the ridge waveguide section with respect to the tapered section is attributed to the reduction of the backward field intensity. The simulations show that this improvement, far from being a general rule, depends on the details of the device geometry.
Dimeric ristocetin flocculates proteins, binds to platelets, and mediates von Willebrand factor-dependent agglutination of platelets (1991)

Ristocetin in aqueous solution dimerizes with an equilibrium dissociation constant of 5.0 x 10(-4) M, i.e. approximately 1.1 mg ml-1 (Waltho, J.P., and Williams, D. H. (1989) J. Am. Chem. Soc. 111, 2475-2480). At concentrations of about 1.0 mg ml-1 ristocetin flocculates many proteins, lyses platelets and, in the presence of von Willebrand factor, agglutinates both fresh and formalin-fixed platelets. Because ristocetin exists as both monomeric and dimeric species, we sought to determine which of these forms flocculates proteins and agglutinates platelets. We found that: 1) the initial rate of flocculation of certain proteins, 2) the initial rate of agglutination of formalin-fixed platelets, and 3) the binding of ristocetin to formalin-fixed platelets are higher order solely with respect to the concentration of ristocetin dimers. As to the operative mechanism, it appears that bifunctional dimers cross-link proteins that possess multiple copies of a common recognition site. Preliminary evidence indicates that a recognition site is a beta-turn of the form X-P-G-X'.
Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of β-cell ATP-sensitive potassium channels (2005)

ATP-sensitive potassium (K(ATP)) channels of pancreatic beta-cells mediate glucose-induced insulin secretion by linking glucose metabolism to membrane excitability. The number of plasma membrane K(ATP) channels determines the sensitivity of beta-cells to glucose stimulation. The K(ATP) channel is formed in the endoplasmic reticulum (ER) on coassembly of four inwardly rectifying potassium channel Kir6.2 subunits and four sulfonylurea receptor 1 (SUR1) subunits. Little is known about the cellular events that govern the channel's biogenesis efficiency and expression. Recent studies have implicated the ubiquitin-proteasome pathway in modulating surface expression of several ion channels. In this work, we investigated whether the ubiquitin-proteasome pathway plays a role in the biogenesis efficiency and surface expression of K(ATP) channels. We provide evidence that, when expressed in COS cells, both Kir6.2 and SUR1 undergo ER-associated degradation via the ubiquitin-proteasome system. Moreover, treatment of cells with proteasome inhibitors MG132 or lactacystin leads to increased surface expression of K(ATP) channels by increasing the efficiency of channel biogenesis. Importantly, inhibition of proteasome function in a pancreatic beta-cell line, INS-1, that express endogenous K(ATP) channels also results in increased channel number at the cell surface, as assessed by surface biotinylation and whole cell patch-clamp recordings. Our results support a role of the ubiquitin-proteasome pathway in the biogenesis efficiency and surface expression of beta-cell K(ATP) channels.
Disruption of <i>URA7</i> and <i>GAL6</i> improves the ethanol tolerance and fermentation capacity of <i>Saccharomyces cerevisiae</i> (2007)

Screening of the homozygous diploid yeast deletion pool of 4741 non-essential genes identified two null mutants (Deltaura7 and Deltagal6) that grew faster than the wild-type strain in medium containing 8% v/v ethanol. The survival rate of the gal6 disruptant in 10% ethanol was higher than that of the wild-type strain. On the other hand, the glucose consumption rate of the ura7 disruptant was better than that of the wild-type strain in buffer containing ethanol. Both disruptants were more resistant to zymolyase, a yeast lytic enzyme containing mainly beta-1,3-glucanase, indicating that the integrity of the cell wall became more resistance to ethanol stress. The gal6 disruptant was also more resistant to Calcofluor white, but the ura7 disruptant was more sensitive to Calcofluor white than the wild-type strain. Furthermore, the mutant strains had a higher content of oleic acid (C18 : 1) in the presence of ethanol compared to the wild-type strain, suggesting that the disruptants cope with ethanol stress not only by modifying the cell wall integrity but also the membrane fluidity. When the cells were grown in medium containing 5% ethanol at 15 degrees C, the gal6 and ura7 disruptants showed 40% and 14% increases in the glucose consumption rate, respectively.
Further stabilization of 3-isopropylmalate dehydrogenase of an extreme thermophile, Thermus thermophilus, by a suppressor mutation method (1996)

We succeeded in further improvement of the stability of 3-isopropylmalate dehydrogenase (IPMDH) from an extreme thermophile, Thermus thermophilus, by a suppressor mutation method. We previously constructed a chimeric IPMDH consisting of portions of thermophile and mesophile enzymes. The chimeric enzyme is less thermostable than the thermophile enzyme. The gene encoding the chimeric enzyme was subjected to random mutagenesis and integrated into the genome of a leuB-deficient mutant of T. thermophilus. The transformants were screened at 76 degrees C in minimum medium, and three independent stabilized mutants were obtained. The leuB genes from these three mutants were cloned and analyzed. The sequence analyses revealed Ala-172-->Val substitution in all of the mutants. The thermal stability of the thermophile IPMDH was improved by introducing the amino acid substitution.
Anti-UAV Defense Requirements for Ground Forces and Hypervelocity Rocket Lethality Models (1992)

This thesis analyzes the threat that unmanned aerial vehicles (UAVs) pose to U.S. ground forces. The operational environment in which both lethal and non-lethal UAVs may be encountered by friendly surface forces is examined to determine the elements of UAV operation which may be exploited in defense against UAVS. Two probability models of the air defense endgame are developed to examine the potential lethality of hypervelocity rocket anti-UAV weapons. These models are used to determine the detonation distance which maximizes the probability that a single hypervelocity rocket kills a UAV. Data used in this study are synthetic to prevent disclosure of classified and proprietary information and allow wider distribution of this thesis. Air Defense, Cookie- Cutter Damage Function, Detonation Distance, Diffuse Gaussian Damage Function, Diffuse Target, Hypervelocity Rocket, Lethality, Optimization, Point Defense, Probability Model, Small Target, Survivability, Susceptibility, Unmanned aerial Vehicle, UAV, Vulnerability, Weapon Delivery Error.
The Diaoyu/Tiaoyutai/Senkaku Islands dispute (2010)

This is a groundbreaking analysis of China's territorial disputes, exploring the successes and failures of negotiations that have taken place between its three neighbours, namely India, Japan and Russia. By using Roberts Putnam's two level game framework, Chung relates the outcome of these disputes to the actions of domestic nationalist groups who
Low voltage hot carrier effects and stress methodology (2002)

The conventional methodology to predict hot carrier device lifetime is to apply stress at high voltages and then extrapolate to lower operating voltage. In this paper hot carrier stress has been applied with different voltages both above and below the silicon to oxide hot electron barrier of 3 V. The results indicate that there is no discontinuity on either side of the barrier in the lifetime versus stress substrate current curve. This means that the methodology used for the high voltage stress can be applied to low voltage stress. This is because the hot electron distribution has a high energy tail. The characteristics of this tail does not change for all practical voltages above or below the barrier.
Knowing and Steering: Mediatization, Planning and Democracy in Victoria, Australia (2004)

Habermas suggests that democracy means that a society is able to know itself and steer itself. This article builds on Habermas’ conception that mediatization is a central impediment to the realization of democracy, while recognizing the locally particular resolution of democratic dilemmas represented by any planning system. Using Victoria, Australia as an example, the article seeks to demonstrate that Habermas’ project offers a means of critiquing existing planning systems. Rather than communicative planning remaining an unattainable ideal, the possibility is explored of Habermasian critique offering practical directions for enhancing the democracy of existing planning systems.
Methodology for repeater insertion management in the RTL, layout, floorplan and fullchip timing databases of the Itanium microprocessor (2000)

In this paper, we describe a methodology for inserting repeaters into the RTL, Layout, Floorplan and Fullchip timing databases of the Itanium processor.
DISPERSION CHARACTERISTICS AND FREQUENCY STABILIZATION OF AN He–Ne GAS LASER (1964)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation W. R. Bennett, S. F. Jacobs, J. T. LaTourrette, P. Rabinowitz; DISPERSION CHARACTERISTICS AND FREQUENCY STABILIZATION OF AN He–Ne GAS LASER. Appl. Phys. Lett. 1 August 1964; 5 (3): 56–58. https://doi.org/10.1063/1.1754050 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Validation of an actuator disk model for numerical simulation of propeller (2014)

In this article, an actuator disk model for simulating propeller is presented by coupling the momentum and the blade element theories. The pressure jump across the disk is computed by integrating the blade aerodynamic characteristics of specific geometric topology, three-dimensional induced velocities and tip-loss correction. Validations have been performed to assess the simulated ability of the developed actuator disk model. The computational results show a good agreement of the experimental data in terms of thrust and torque coefficients. Moreover, the flow visualization indicated a considerable accuracy by comparing with full modelling computation. The actuator disk model can be therefore be regarded as a reliable model for predicting propeller flow.
Passivation of zinc–tin–oxide thin-film transistors (2005)

A methodology for the passivation of bottom-gate thin-film transistors (TFTs) utilizing zinc–tin–oxide as the channel layer and silicon dioxide as the passivation layer is presented. This methodology involves annealing of the TFT after channel layer deposition and an additional anneal after thermal evaporation of a SiO2 passivation layer. Passivated zinc–tin–oxide TFTs possess electrical characteristics equivalent to those of unpassivated, air-exposed devices. In contrast, TFT electrical performance is dramatically degraded if a zinc–tin–oxide TFT is covered with a dielectric layer and does not undergo both types of anneal. In addition to silicon dioxide, successful passivation of zinc–tin–oxide TFTs is accomplished using thermally evaporated calcium fluoride, germanium oxide, strontium fluoride, or antimony oxide as passivation dielectrics.
Design, Synthesis, and Biological Activity of NCC149 Derivatives as Histone Deacetylase 8‐Selective Inhibitors (2014)

We recently discovered N-hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide (NCC149) as a potent and selective histone deacetylase 8 (HDAC8) inhibitor from a 151-member triazole compound library using a click chemistry approach. In this work, we present a series of NCC149 derivatives bearing various aromatic linkers that were designed and synthesized as HDAC8-selective inhibitors. A series of in vitro assays were used to evaluate the newly synthesized compounds, four of which showed HDAC8 inhibitory activity similar to that of NCC149, and one of which displayed HDAC8 selectivity superior to that of NCC149. In addition, these top four compounds induced the increase of acetylated cohesin (an HDAC8 substrate) in HeLa cells in a dose-dependent manner, indicating inhibition of HDAC8 in the cells. While none of these compounds enhanced the acetylation of H3K9 (a substrate of HDAC1 and 2), only one compound refrained from increasing α-tubulin acetylation, a substrate of HDAC6, indicating that this compound is more selective for HDAC8 than the other derivatives. Furthermore, this HDAC8-selective inhibitor suppressed the growth of T-cell lymphoma cells more potently than did NCC149. These findings are useful for the further development of HDAC8-selective inhibitors.
Application of V-groove technology to InP solar cells (1990)

InP solar cells with a V-grooved front surface were fabricated and tested. The cells were made by the closed-ampoule thermal diffusion of sulfur into Zn-doped InP substrates on which the grooves were formed by a wet-chemical anisotropic etch. Reflectivity measurements show significantly lower reflectance for the microgrooved cell compared to a planar wafer. Cell short-circuit current, open-circuit voltage, efficiency, and quantum efficiency as a function of wavelength were measured. Compared to planar cells, the V-grooved cells showed increased short circuit current over the entire spectral range, with a slight decrease in voltage.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Economic range checks in pascal (1978)

Abstract A Pascal implementation is described which exploits the information provided by subrange type declarations to minimize the run‐time checking involved in detecting range violations. An evaluation of its performance is given, and some possible modifications are discussed.
Image categorization using Fisher kernels of non-iid image models (2012)

The bag-of-words (BoW) model treats images as an unordered set of local regions and represents them by visual word histograms. Implicitly, regions are assumed to be identically and independently distributed (iid), which is a poor assumption from a modeling perspective. We introduce non-iid models by treating the parameters of BoW models as latent variables which are integrated out, rendering all local regions dependent. Using the Fisher kernel we encode an image by the gradient of the data log-likelihood w.r.t. hyper-parameters that control priors on the model parameters. Our representation naturally involves discounting transformations similar to taking square-roots, providing an explanation of why such transformations have proven successful. Using variational inference we extend the basic model to include Gaussian mixtures over local descriptors, and latent topic models to capture the co-occurrence structure of visual words, both improving performance. Our models yield state-of-the-art categorization performance using linear classifiers; without using non-linear transformations such as taking square-roots of features, or using (approximate) explicit embeddings of non-linear kernels.