gebhart/patrepeval huggingface dataset:
In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy (2012)

The use of a novel all-optical photoacoustic scanner for imaging the development of tumor vasculature and its response to a therapeutic vascular disrupting agent is described. The scanner employs a Fabry-Perot polymer film ultrasound sensor for mapping the photoacoustic waves and an image reconstruction algorithm based upon attenuation-compensated acoustic time reversal. The system was used to noninvasively image human colorectal tumor xenografts implanted subcutaneously in mice. Label-free three-dimensional in vivo images of whole tumors to depths of almost 10 mm with sub-100-micron spatial resolution were acquired in a longitudinal manner. This enabled the development of tumor-related vascular features, such as vessel tortuosity, feeding vessel recruitment, and necrosis to be visualized over time. The system was also used to study the temporal evolution of the response of the tumor vasculature following the administration of a therapeutic vascular disrupting agent (OXi4503). This revealed the well-known destruction and recovery phases associated with this agent. These studies illustrate the broader potential of this technology as an imaging tool for the preclinical and clinical study of tumors and other pathologies characterized by changes in the vasculature.
65. α- and β-santalols (1935)

A. E. Bradfield, A. R. Penfold and J. L. Simonsen, J. Chem. Soc., 1935, 309 DOI: 10.1039/JR9350000309
Kinetics of Homoacetic Fermentation of Lactate by <i>Clostridium formicoaceticum</i> (1987)

Clostridium formicoaceticum homofermentatively converted lactate to acetate at mesophilic temperatures (30 to 42 degrees C) and at pHs between 6.6 and 9.6. The production of acetate was found to be growth associated. Approximately 0.96 g of acetic acid and 0.066 g of cells were formed from each gram of lactic acid consumed at 37 degrees C. The concentration of the substrate (lactate) had little or no effect on the growth rate; however, the fermentation was inhibited by acetic acid. The bacterium grew at an optimal pH of 7.6 and an optimal temperature of 37 degrees C. Small amounts of bicarbonate were stimulatory to bacterial growth. Bacterial growth was enhanced, however, by the use of higher concentrations of bicarbonate in the media, only because higher buffer capacities were obtained and proper medium pH could be maintained for growth. Based on its ability to convert lactate to acetate, this homoacetic bacterium may be important in the anaerobic methanogenic process when lactate is a major intermediary metabolite.
The Role of Psychotherapy in the Treatment of Depression (1996)

Persons AND colleagues 1 have raised some intriguing, provocative, and clinically important issues in their review and critique of two clinical practice guidelines: one by the Agency for Health Care Policy and Research (AHCPR), 2, 3 aimed at primary care (PC) practitioners, and the second by the American Psychiatric Association (APA), 4 directed toward psychiatrists. In essence, Persons et al find a greater basis for recommending psychotherapy alone as a treatment for major depressive disorder, and they view the stronger call for combined treatment (medication and psychotherapy) by the APA as lacking empirical support. They make several recommendations for subsequent guideline development (eg, multidisciplinary panels, comments on cost, highest reliance on randomized controlled trials [RCTs], periodic revisions, etc). The following comments, intended to be explanatory rather than in defense of, in particular, the AHCPR guidelines, focus on the philosophical basis underpinning the development and use of clinical practice guidelines. Assumptions made
Ion beam texturing (1977)

Wehner and Hajicek have reported that a microscopic surface texture could be created by sputter etching a surface while simultaneously sputter depositing a lower sputter yield material onto the surface. A xenon ion beam source has been used to perform this texturing process on samples as large as 3 cm diam. Ion‐beam‐textured surface structures have been characterized with SEM photomicrographs for a large number of materials, including Cu, Al, Si, Ti, Ni, Fe, stainless steel, Au, and Ag. Surfaces have been textured using a variety of low sputter yield materials—Ta, Mo, Nb, and Ti. The initial stages of the texture creation have been documented, and the technique of ion beam sputter removal of any remaining deposited material has been studied. A number of other texturing parameters have been studied such as the variation of the texture with ion beam power, surface temperature, and the rate of texture growth with sputter etching time.
Monolithically series-interconnected GaInAsSb/AlGaAsSb/GaSb thermophotovoltaic devices with an internal backsurface reflector formed by wafer bonding (2003)

GaInAsSb/AlGaAsSb/GaSb thermophotovoltaic (TPV) cells were monolithically interconnected in series to build open-circuit voltage Voc. GaInAsSb epitaxial layers were transferred to GaAs by wafer bonding with SiOx/Ti/Au, which provides electrical isolation of individual cells and forms an internal backsurface reflector. This configuration is compatible with monolithic series interconnection of TPV cells; can mitigate the requirements of filters used for front-surface spectral control; and has the potential to improve TPV device performance. Wafer-bonded GaInAsSb TPV cells exhibit nearly linear voltage building. At a short-circuit current density of 0.4 A/cm2, Voc of a single TPV cell is 0.2 V, compared to 0.37 and 1.8 V for 2- and 10-junction series-interconnected TPV cells, respectively.
Line Circuit Interfaces for a Digital Switching System (1979)

Crucial to the design of digital switching systems for local switching applications is the line circuit interface. It forms the boundary between the analog, 2-wire, subscriber loop, with its attendant environment hostile to low-voltage electronics, and the digital logic environment. ITT North's DSS uses a Quad Line Circuit (QLC) that provides the line circuit interface between four subscriber loops and two PCM multiplexed highways. The QLC contains per-line elements consisting of an electronic 2W/4W hybrid, transmit and receive PCM filters, a codec, two card-mounted relays, and distributed logic for various gating and clocking functions. In addition, there is digital logic common to all four lines for interfacing with redundant microprocessors common to 320 lines. Design of the QLC in a dynamic technology evolution is discussed, and several evolutions of the initial design are presented.
Computational models of Bitemporal, Bifrontal and Right Unilateral ECT predict differential stimulation of brain regions associated with efficacy and cognitive side effects (2017)

In this exploratory study on three realistic head models, Bitemporal ECT resulted in greater direct stimulation of deep midline structures and also left temporal and inferior frontal regions. Interpreted in light of existing knowledge on depressive pathophysiology and cognitive neuroanatomy, it is suggested that the former sites are related to efficacy and the latter to cognitive deficits. We hereby propose an approach using binarised subtraction models that can be used to optimise, and even individualise, ECT therapies.
Computing 3-D head orientation from a monocular image sequence (2002)

An approach for estimating 3D head orientation in a monocular image sequence is proposed. The approach employs recently developed image-based parameterized tracking for face and face features to locate the area in which a sub-pixel parameterized shape estimation of the eye's boundary is performed. This involves tracking of five points (four at the eye corners and the fifth is the lip of the nose). The authors describe an approach that relies on the coarse structure of the face to compute orientation relative to the camera plane. Our approach employs projective invariance of the cross-ratios of the eye corners and anthropometric statistics to estimate the head yaw, roll and pitch. Analytical and experimental results are reported.
Probability of heat wave impact on the occupants of different star rated houses and the benefits of upgrading house star ratings to 6 star: a case study for Victoria (2015)

Heat events have killed more people than any other natural hazard experienced in Australia over the past 200 years. In late January 2009, South-eastern Australia was affected by one of the most extreme heat wave which claimed 374 lives. The same region suffered another heat wave on January 2014 which resulted in 167 excess deaths. In the present study, a statistical analysis have been carried out to calculate the distribution of different star rated houses in Victoria and the percentage of people living in different star rated houses. It is then followed by the probability analysis of experiencing heat stress by the occupants of different star rated houses. Building simulation software EnergyPlus V8.1 was used to calculate the severe heat stress hours inside different star rated houses. The results showed that approximately 55% of the total Victorian people lives in a house with star ratings 2 or less. During heat wave, severe heat stress hours inside a lower star rated house were found to be significantly higher than a 6 star rated house. On a typical 2009 heat wave day, the probability of experiencing two severe heat stress hours by the occupants of 1 and 2 star houses is over 95% compared to only 20% in case of 6 star houses. The results also showed that health impact of heat wave can be reduced significantly by upgrading house star rating to 6 star.
Parallel manipulators.Part I :Theory design,kinematics,dynamics and control (1987)

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Synthesis and antimalarial evaluation of some 1,7-naphthridines and 2,9-diazaanthracenes (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antimalarial evaluation of some 1,7-naphthridines and 2,9-diazaanthracenesPing-Lu Chien and C. C. ChengCite this: J. Med. Chem. 1968, 11, 1, 164–167Publication Date (Print):January 1, 1968Publication History Published online1 May 2002Published inissue 1 January 1968https://pubs.acs.org/doi/10.1021/jm00307a043https://doi.org/10.1021/jm00307a043research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SC29EK, a Peptide Fusion Inhibitor with Enhanced α-Helicity, Inhibits Replication of Human Immunodeficiency Virus Type 1 Mutants Resistant to Enfuvirtide (2008)

Peptides derived from the alpha-helical domains of human immunodeficiency virus (HIV) type 1 (HIV-1) gp41 inhibit HIV-1 fusion to the cell membrane. Enfuvirtide (T-20) is a peptide-based drug that targets the step of HIV fusion, and as such, it effectively suppresses the replication of HIV-1 strains that are either wild type or resistant to multiple reverse transcriptase and/or protease inhibitors. However, HIV-1 variants with T-20 resistance have emerged; therefore, the development of new and potent inhibitors is urgently needed. We have developed a novel HIV fusion inhibitor, SC34EK, which is a gp41-derived 34-amino-acid peptide with glutamate (E) and lysine (K) substitutions on its solvent-accessible site that stabilize its alpha-helicity. Importantly, SC34EK effectively inhibits the replication of T-20-resistant HIV-1 strains as well as wild-type HIV-1. In this report, we introduce SC29EK, a 29-amino-acid peptide that is a shorter variant of SC34EK. SC29EK blocked the replication of T-20-resistant HIV-1 strains and maintained antiviral activity even in the presence of high serum concentrations (up to 50%). Circular dichroism analysis revealed that the alpha-helicity of SC29EK was well maintained, while that of the parental peptide, C29, which showed moderate and reduced inhibition of wild-type and T-20-resistant HIV-1 strains, was lower. Our results show that the alpha-helicity in a peptide-based fusion inhibitor is a key factor for activity and enables the design of short peptide inhibitors with improved pharmacological properties.
Smoking-Related Weight Concerns and Obesity: Differences Among Normal Weight, Overweight, and Obese Smokers Using a Telephone Tobacco Quitline (2012)

Overweight and obese smokers, particularly women, express substantial concern about gaining weight after quitting. It is possible that smokers who begin quitline treatment with a BMI in the obese range may benefit from adjunctive interventions designed to address smoking-related weight concerns.
Proactive Cache Placement on Cooperative Client Caches for Online Social Networks (2015)

This paper investigates cache placement on a cooperative cache built from individual client caches in an online social network or web service. We use a service that maintains a mapping between content and the clients that cache it, and propose cache placement schemes that leverage relationships between clients (for example, social links) and workload statistics, proactively placing content on clients that are likely to access it. We evaluate efficacy through simulation, comparing our schemes against commonly used cache placement algorithms as well as optimal placement. We synthesize a workload to match characteristics of online social networks. Simulation results of our proposed caching schemes impose moderate network overhead and show considerable improvement to the client's cache hit ratio, even under churn.
Directed evolution of an industrially important enzyme (1997)

Conference Abstract| February 01 1997 Directed evolution of an industrially important enzyme Duncan J. H. Gaskin; Duncan J. H. Gaskin 1Institute of Food Research, Earley Gate, Whiteknights Rd, Reading, UK, RG6 6BZ Search for other works by this author on: This Site PubMed Google Scholar Anne H. Bovagnet; Anne H. Bovagnet 2Institute of Food Research, Earley Gate, Whiteknights Rd, Reading, UK, RG6 6BZ Search for other works by this author on: This Site PubMed Google Scholar Nigel A. Turner; Nigel A. Turner 3Institute of Food Research, Earley Gate, Whiteknights Rd, Reading, UK, RG6 6BZ Search for other works by this author on: This Site PubMed Google Scholar Evgeny N. Vulfson Evgeny N. Vulfson 4Institute of Food Research, Earley Gate, Whiteknights Rd, Reading, UK, RG6 6BZ Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1997) 25 (1): 15S. https://doi.org/10.1042/bst025015s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Duncan J. H. Gaskin, Anne H. Bovagnet, Nigel A. Turner, Evgeny N. Vulfson; Directed evolution of an industrially important enzyme. Biochem Soc Trans 1 February 1997; 25 (1): 15S. doi: https://doi.org/10.1042/bst025015s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: Lip+/Est+ lipase positive and esterase positive, Lip-/Est- lipase negative and esterase negative, Lip+/Est- lipase positive and esterase negative, Lip-/Est+ lipase negative and esterase positve This content is only available as a PDF. © 1997 Biochemical Society1997 Article PDF first page preview Close Modal You do not currently have access to this content.
Ginseng Intake and Gastric Cancer Risk in the Shanghai Women's Health Study Cohort (2007)

Ginseng is a deciduous perennial plant that is cultivated in East Asia and North America, and is commonly used as a herbal medicine in East Asian countries ([1][1]). The most commonly used types of ginseng are American ginseng ( Panax qinquefolius ), and white and red ginseng, which are prepared
<title>Wide-viewing-area glassless stereoscopic display using multiple projectors</title> (1998)

The stereoscopic display using a curved-directional- reflection screen is a promising approach towards realizing a 3D imaging system that does not require use of special glasses. However, the limited viewing area has been a drawback. In this paper, we describe how the viewing area can be made wider. Our system uses four sets of liquid- crystal projectors that provide four images corresponding to each viewing area. The viewing area is expanded about three times wider than that of a conventional system using two projectors. Especially if the viewer is sitting in a fixed chair, precise control of the viewer's position is not needed due to this wide viewing area.
Kinetic Analysis of Interaction of Eukaryotic Release Factor 3 with Guanine Nucleotides (2006)

Eukaryotic translation termination is mediated by two release factors: eRF1 recognizes stop codons and triggers peptidyl-tRNA hydrolysis, whereas eRF3 accelerates this process in a GTP-dependent manner. Here we report kinetic analysis of guanine nucleotide binding to eRF3 performed by fluorescence stopped-flow technique using GTP/GDP derivatives carrying the fluorescent methylanthraniloyl (mant-) group, as well as thermodynamic analysis of eRF3 binding to unlabeled guanine nucleotides. Whereas the kinetics of eRF3 binding to mant-GDP is consistent with a one-step binding model, the double-exponential transients of eRF3 binding to mant-GTP indicate a two-step binding mechanism, in which the initial eRF3.mant-GTP complex undergoes subsequent conformational change. The affinity of eRF3 for GTP (K(d), approximately 70 microM) is about 70-fold lower than for GDP (K(d), approximately 1 microM) and both nucleotides dissociate rapidly from eRF3 (k(-1)(mant-GDP) approximately 2.4 s(-1); k(-2)(mant-GTP) approximately 3.3 s(-1)). Whereas not influencing eRF3 binding to GDP, association of eRF3 with eRF1 at physiological Mg(2+) concentrations specifically changes the kinetics of eRF3/mant-GTP interaction and stabilizes eRF3.GTP binding by two orders of magnitude (K(d) approximately 0.7 microM) due to lowering of the dissociation rate constant approximately 24-fold (k(-1)(mant-GTP) approximately 0.14s(-1) approximately 0.14 s(-1)). Thus, eRF1 acts as a GTP dissociation inhibitor (TDI) for eRF3, promoting efficient ribosomal recruitment of its GTP-bound form. 80 S ribosomes did not influence guanine nucleotide binding/exchange on the eRF1 x eRF3 complex. Guanine nucleotide binding and exchange on eRF3, which therefore depends on stimulation by eRF1, is entirely different from that on prokaryotic RF3 and unusual among GTPases.
The Silica‐Like Extended Polymorphism of Cobalt(<scp>II</scp>) Imidazolate Three‐Dimensional Frameworks: X‐ray Single‐Crystal Structures and Magnetic Properties (2003)

Five polymorphous frameworks of cobalt(II) imidazolates (1-5) have been prepared by solvatothermal syntheses. Of these, compound 3 has already been synthesized in a gas-phase reaction by Seel et al. in 1969 and structurally characterized by Sturm et al. in 1975. The new synthetic strategy affords four polymorphous frameworks of cobalt(II) imidazolates (1, 2, 4, 5) of crystalline substances, of which the compound 4 (a = b = 23.450(3), c = 12.460(3) A, tetragonal, I4(1)cd, Z = 16) is an isomorphous compound of [Zn(im)(2)]( infinity ), which was also synthesized in a gas-phase reaction in 1980. The frameworks of compounds 1 and 2 are porous and isostructural; they have the same framework topology that represents a novel uninodal (6,4)-net: 1: a = 18.513(4), b = 24.368(5), c = 9.2940(19) A, orthorhombic, Fdd2, Z = 16; 2: a = 17.635(4), b = 27.706(6), c = 9.0810(18) A, orthorhombic, Fdd2, Z = 16. The framework of compound 5 exhibits a topology of zeolitic structure with the unit-cell parameters: a = 24.3406(8), b = 9.4526(3), c = 24.8470(8) A, beta = 91.977(1) degrees, monoclinic, P2(1)/n, Z = 4. All polymorphous frameworks of cobalt(II) imidazolates reflect the structural features of silica (SiO(2)) and also exhibit different magnetic behaviors, although the imidazolates transmit the antiferromagnetic coupling between the cobalt(II) ions in all cases. However, the uncompensated antiferromagnetic couplings arise from spin-canting are sensitive to the structures: compound 1 is an antiferromagnet with T(N) = 13.11 K; compounds 2-4 are weak ferromagnets (canted antiferromagnets): 2 shows a very weak ferromagnetism below 15 K, 3 exhibits a relatively strong ferromagnetism below 11.5 K and a coercive field (H(C)) of 1800 Oe at 1.8 K, and 4 displays the strongest ferromagnetism of the three cobalt imidazolates and demonstrates a T(C) of 15.5 K with a coercive field, H(C), of 7300 Oe at 1.8 K. However, compound 5 seems to be a hidden canted antiferromagnet with a magnetic ordering temperature of 10.6 K.
Low-Density Lipoprotein Cholesterol and the Risk of Dementia With Stroke (1999)

Elevated levels of LDL cholesterol were associated with the risk of dementia with stroke in elderly patients. Further study is needed to determine whether treatment of elevated LDL cholesterol levels will reduce the risk of dementia with stroke.
Pancreatitis post-bone marrow transplantation. (1996)

Pancreatitis has been reported as a rare complication after bone marrow transplantation (BMT). This paper reports a series of three cases of pancreatitis post-BMT and reviews the literature. Pancreatitis occurred in three of 68 (4.4%) of BMT cases in our transplant program. The etiology of such cases is multifactorial and includes drugs, graft-versus-host disease, infection, cholecystitis, and the lipid in total parenteral nutrition. Pancreatitis should be included in the differential diagnosis of abdominal pain post-BMT. The development of a pancreatic pseudocyst in an immunocompromised host may require surgical drainage since infected pseudocysts are not drained adequately by radiologically guided techniques.
Hydrogen Density Measurements Using an Open-Ended Microwave Cavity (1972)

The density measurement of liquid hydrogen and two-phase mixtures of liquid and gaseous hydrogen is considered. This paper describes a complete prototype system that uses an open-ended microwave cavity for making dynamic density measurements of flowing hydrogen in a transfer line. The theory of operation along with test results for both the single- and two-phase cases are presented and discussed.