gebhart/patrepeval huggingface dataset:
Systematic Review of Arthroscopic Rotator Cuff Repair and Mini-Open Rotator Cuff Repair (2007)

Nho, Shane J. MD, MS; Shindle, Michael K. MD; Sherman, Seth L. MD; Freedman, Kevin B. MD, MSCE; Lyman, Stephan PhD; MacGillivray, John D. MD Author Information
Paleomagnetism: magnetic domains to geologic terranes (1992)

Introduction to geomagnetism Ferromagnetic minerals Origins of natural remanent magnetism Sampling, measurement, and display of NRM Paleomagnetic stability Statistics of paleomagnetic data Paleomagnetic poles Special topics in rock magnetism Geochronologic applications Applications to paleogeography Applications to regional tectonics Appendix: Derivations
Combination of COFRADIC and high temperature – extended column length conventional liquid chromatography: A very efficient way to tackle complex protein samples, such as serum (2007)

The previously reported COmbined FRActional DIagonal Chromatography (COFRA-DIC) methodology, in which a subset of peptides representative for their parent proteins are sorted, is particularly powerful for whole proteome analysis. This peptide-centric technology is built around diagonal chromatography, where peptide separations are crucial. This paper presents high efficiency peptide separations, in which four 250 x 2.1 mm, 5 microm Zorbax 300SB-C18 columns (total length 1 m) were coupled at operating temperatures of 60'C using a dedicated LC oven and conventional LC equipment. The high efficiency separations were combined with the COFRADIC procedure. This extremely powerful combination resulted, for the analysis of serum, in an increase in the uniquely identified peptide sequences by a factor of 2.6, compared to the COFRADIC procedure on a 25 cm column. This is a reflection of the increased peak capacity obtained on the 1 m column, which was calculated to be a factor 2.7 higher than on the 25 cm column. Besides more efficient sorting, less ion suppression was noticed.
Multiple opiate receptors and their functional significance. (1983)

There is ample evidence from studies of peripheral isolated organs, binding of opiate receptor ligands to brain membranes and behavioural experiments that opiate receptors are not homogeneous but consist of different types such as the mu- (= morphine), delta- (= enkephalin), kappa- (= ketocyclazocine) and the epsilon- (= beta-endorphin) receptors. In addition, there are indications for subtypes within the particular classes of receptors, at least in the case of mu- and kappa-receptors. In one organ or particular brain structure, several types of receptors can be present-though big differences in the relative concentrations between various brain areas exist. The precise nature of the relationship between the multiplicity of opiate receptors and the multiplicity of endogenous opioids is not clear. The enkephalins and dynorphin appear to be, however, related to, respectively, delta- and kappa-receptors. According to our present knowledge, there is no strict relationship between certain physiological functions (or pharmacological actions) and the activation of a particular receptor type; for example, mu-, delta- and kappa-receptors are involved in pain modulation.
X.—NEW BOOKS (1964)

X.—NEW BOOKS Get access Time and the Physical World. By RICHARD SCHLEGEL. Michigan State University Press, 1961. Pp. xii + 211. $7.50. DOLORES WRIGHT DOLORES WRIGHT Search for other works by this author on: Oxford Academic Google Scholar Mind, Volume LXXIII, Issue 289, January 1964, Pages 150–154, https://doi.org/10.1093/mind/LXXIII.289.150 Published: 01 January 1964
对得克萨斯州Gaines县Seminole San Andres单元—碳酸盐岩缓坡储层进行综合性储层特征研究 (1998)

在建立地质和储层模型中最重要的问题是确定地质格架,它是确定流动单元,推导井的数据和模拟流体流动的基础。对于Seminole San Andres单元(SSAU),根据露头模拟和岩芯确定的高频率旋回(HFC′S)和岩石组构单元可用来校正电缆测井。用作为一种地质格架的HFC′S内的岩石组构单元来建立SSAU两条剖面区储层和露头的模拟模型。使用这些模型对影响采收率关键因素的研究进行模拟。在模拟浅海碳酸盐岩缓坡储层中,HFC′S和岩石组构单元是两项关键的尺度。对叠加在HFC′S内的岩石组构相加以描述,可为建立地质和储层模型提供最准确的格架。因为不连续的岩石物性函数可与岩石组构相拟合,而流体的流动能与岩石组构流动单元之间的Kh值相适应。利用粒间孔隙度和渗透率之间的岩石组构特殊转换就可以计算渗透率。岩芯分析数据表明:分离的晶洞孔隙对影响相对渗透率和毛细管压力的测量有着巨大的作用。我们研究了对随机模拟的地层限制的影响。对比了常规性线型推导产生的地质模拟,以及具有地层限制的随机模型和没有地层限制的随机模型。只有当受到岩石组构流动单元的制约时,碳酸盐岩的地层形态才可能在随机识别中被观察到。在现实中的模拟结果与采收率的模拟结果一样,但不同于产量知注入量的模拟结果。根据垂向渗透率和水平渗透率的比值(Kvh),研究了渗透率在垂向上的递增。随着垂直网格块尺寸上升到平均旋回尺寸20英尺(6.1米),渗透率比值呈指数下降,并保持了对网格块尺寸超过20英尺(为HFC′S的平均厚度)的0.06的数值。从模型中得出结果表明:影响采收率的主要因素是—岩石组构流动单元的叠加形式。Kvh和致密泥岩的分布。
Role of Solvent Parameters in the Regeneration of Cellulose from Ionic Liquid Solutions (2012)

The ionic liquids 1-ethyl-3-methylimidazolium acetate [emim]OAc, N,N,N,N-tetramethylguanidium propionate [TMGH]EtCO(2), and N,N,N,N-tetramethylguanidium acetate [TMGH]OAc, and the traditional cellulose solvent N-methylmorpholine N-oxide NMMO were characterized for their Kamlet-Taft (KT) values at several water contents and temperatures. For the ionic liquids and NMMO, thresholds of regeneration of cellulose solutions by water were determined using nephelometry and rheometry. Regeneration from wet IL was found to be asymmetric compared to dissolution into wet IL. KT parameters were found to remain almost constant at temperatures, between 20-100 °C, even at different water contents. Among the KT parameters, the β value was found to change most drastically, with an almost linear decrease upon addition of water. The ability of the mixtures to dissolve cellulose was best explained by the difference β-α (net basicity), rather than β alone. Regeneration of cellulose starts at thresholds values of approximately β < 0.8 (β-α < 0.35) and displayed four phases.
Reductive Metabolism of the Nitroimidazole-Based Hypoxia-Selective Cytotoxin NLCQ-1 (NSC 709257) (2003)

The enzymatic cell-free metabolism of the novel hypoxia-selective cytotoxin 4-[3-(2-nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1) was investigated under hypoxic or aerobic conditions in the presence of purified reductive enzymes or isolated rat liver microsomes by monitoring the parent compound with HPLC-UV analysis. Enzymatic reduction of NLCQ-1 with isolated rat liver microsomes and NADPH or NADH showed that, only under hypoxic conditions, ca. 45% and 60% of the parent compound was reduced, respectively, within 1 h of incubation (37 degrees C). Under identical conditions but in the presence of 2'-AMP (a P450 reductase inhibitor), 6-propyl-2-thiouracil or p-hydroxymercuribenzoate (cytochrome b5 reductase inhibitors), NLCQ-1 reduction was inhibited. Enzymatic cell-free metabolism of NLCQ-1 with recombinant human DT-diaphorase (DTD) and NADPH or NADH under hypoxic or aerobic conditions showed that < or = 5% of the compound was reduced within 2 h. Reduction kinetics with human P450 reductase-expressing microsomes showed ca. 75% or 50% reduction of NLCQ-1 under hypoxic or aerobic conditions, respectively, after 2 h incubation. These results suggest that DTD is not involved in the initial steps of the bioreductive metabolism of NLCQ-1, although it could be involved with metabolites of NLCQ-1, and that cytochrome P450 and cytochrome b5 reductases play a significant role in the bioreductive metabolism of NLCQ-1.
Introducing the RECOLA multimodal corpus of remote collaborative and affective interactions (2013)

We present in this paper a new multimodal corpus of spontaneous collaborative and affective interactions in French: RECOLA, which is being made available to the research community. Participants were recorded in dyads during a video conference while completing a task requiring collaboration. Different multimodal data, i.e., audio, video, ECG and EDA, were recorded continuously and synchronously. In total, 46 participants took part in the test, for which the first 5 minutes of interaction were kept to ease annotation. In addition to these recordings, 6 annotators measured emotion continuously on two dimensions: arousal and valence, as well as social behavior labels on live dimensions. The corpus allowed us to take self-report measures of users during task completion. Methodologies and issues related to affective corpus construction are briefly reviewed in this paper. We further detail how the corpus was constructed, i.e., participants, procedure and task, the multimodal recording setup, the annotation of data and some analysis of the quality of these annotations.
Glass-like dynamics of collective cell migration (2011)

Collective cell migration in tissues occurs throughout embryonic development, during wound healing, and in cancerous tumor invasion, yet most detailed knowledge of cell migration comes from single-cell studies. As single cells migrate, the shape of the cell body fluctuates dramatically through cyclic processes of extension, adhesion, and retraction, accompanied by erratic changes in migration direction. Within confluent cell layers, such subcellular motions must be coupled between neighbors, yet the influence of these subcellular motions on collective migration is not known. Here we study motion within a confluent epithelial cell sheet, simultaneously measuring collective migration and subcellular motions, covering a broad range of length scales, time scales, and cell densities. At large length scales and time scales collective migration slows as cell density rises, yet the fastest cells move in large, multicell groups whose scale grows with increasing cell density. This behavior has an intriguing analogy to dynamic heterogeneities found in particulate systems as they become more crowded and approach a glass transition. In addition we find a diminishing self-diffusivity of short-wavelength motions within the cell layer, and growing peaks in the vibrational density of states associated with cooperative cell-shape fluctuations. Both of these observations are also intriguingly reminiscent of a glass transition. Thus, these results provide a broad and suggestive analogy between cell motion within a confluent layer and the dynamics of supercooled colloidal and molecular fluids approaching a glass transition.
Fluorinated Analogues of the Imidazole Insect Growth Regulator KK-42 (1990)

The preparation of compounds l b , l c and l e , monofluoro and trifluoromethyl analogues of the imidazole KK-42 ( l a ) is reported.The synthetic sequence involves the formation of an imine between the appropriate fluoro aldehyde and benzylamine, followed by condensation with tosylmethyl isocyanide (TosMIC) in basic media.Each step has been thoroughly studied and the whole procedure has been optimized for the case of model imidazole l a .It has been observed that when possible, the imine formation proceeds with a concomitant UE isomerization on the olefin moiety of the a,Punsaturated system.Finally, data on the biological activity of the title compounds as ecdysone antagonists are also presented.
Probing the Enantioselectivity of Chiral Pesticides (2006)

ADVERTISEMENT RETURN TO ISSUEPREVFEATURENEXTProbing the Enantioselectivity of Chiral PesticidesArthur W. GarrisonCite this: Environ. Sci. Technol. 2006, 40, 1, 16–23Publication Date (Web):January 1, 2006Publication History Published online1 January 2006Published inissue 1 January 2006https://pubs.acs.org/doi/10.1021/es063022fhttps://doi.org/10.1021/es063022fnewsACS Publications. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2832Altmetric-Citations297LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (502 KB) Get e-Alertsclose SUBJECTS:Pest control,Stereoselectivity Get e-Alerts
Cellular ras Activity Is Required for Passage through Multiple Points of the G <sub>0</sub> /G <sub>1</sub> Phase in BALB/c 3T3 Cells (1994)

Microinjection experiments demonstrated a requirement for cellular ras activity late in G1. In this study, we used two separate methods to identify an additional requirement for cellular ras activity early in the G0/G1 phase of the cell cycle. Quiescent BALB/c cells were injected with anti-ras antibody prior to stimulation with serum. The cells would therefore be inhibited in progression through the cell cycle at the earliest point requiring ras function. Alternatively, cells were inhibited in late G1 as in previous studies by injecting anti-ras several hours after serum addition to quiescent cells. The injected cultures were then treated with chemical cell cycle inhibitors known to function in mid-G1. Cells injected with anti-ras prior to serum stimulation were retained at a point of ras requirement prior to the execution point of the chemical inhibitor, while cells injected 3 to 5 h after serum stimulation were retained at a point of ras requirement downstream of the execution point of the chemical inhibitor. To confirm these results, quiescent BALB/c cells were injected with anti-ras antibody prior to or several hours following serum addition. In this case, however, second injections of oncogenic ras or adenoviral E1A protein were performed to overcome the inhibitory effects of the anti-ras antibody. Cells injected prior to serum addition were clearly inhibited at an early point of Ras requirement since they required 5 or 6 h longer to enter S phase than cells injected with anti-ras antibody after serum addition.
Ring Confidential Transactions (2016)

This article introduces a method of hiding transaction amounts in the strongly decentralized anonymous cryptocurrency Monero. Similar to Bitcoin, Monero is a cryptocurrency which is distributed through a proof-of-work “mining” process having no central party or trusted setup. The original Monero protocol was based on CryptoNote, which uses ring signatures and one-time keys to hide the destination and origin of transactions. Recently the technique of using a commitment scheme to hide the amount of a transaction has been discussed and implemented by Bitcoin Core developer Gregory Maxwell. In this article, a new type of ring signature, A Multilayered Linkable Spontaneous Anonymous Group signature is described which allows one to include a Pedersen Commitment in a ring signature. This construction results in a digital currency with hidden amounts, origins and destinations of transactions with reasonable efficiency and verifiable, trustless coin generation. The author would like to note that early drafts of this were publicized in the Monero Community and on the #bitcoin-wizards IRC channel. Blockchain hashed drafts are available showing that this work was started in Summer 2015, and completed in early October 2015. An eprint is also available at http://eprint.iacr.org/2015/1098.
Creating Novel Activated Factor XI Inhibitors through Fragment Based Lead Generation and Structure Aided Drug Design (2015)

Activated factor XI (FXIa) inhibitors are anticipated to combine anticoagulant and profibrinolytic effects with a low bleeding risk. This motivated a structure aided fragment based lead generation campaign to create novel FXIa inhibitor leads. A virtual screen, based on docking experiments, was performed to generate a FXIa targeted fragment library for an NMR screen that resulted in the identification of fragments binding in the FXIa S1 binding pocket. The neutral 6-chloro-3,4-dihydro-1H-quinolin-2-one and the weakly basic quinolin-2-amine structures are novel FXIa P1 fragments. The expansion of these fragments towards the FXIa prime side binding sites was aided by solving the X-ray structures of reported FXIa inhibitors that we found to bind in the S1-S1'-S2' FXIa binding pockets. Combining the X-ray structure information from the identified S1 binding 6-chloro-3,4-dihydro-1H-quinolin-2-one fragment and the S1-S1'-S2' binding reference compounds enabled structure guided linking and expansion work to achieve one of the most potent and selective FXIa inhibitors reported to date, compound 13, with a FXIa IC50 of 1.0 nM. The hydrophilicity and large polar surface area of the potent S1-S1'-S2' binding FXIa inhibitors compromised permeability. Initial work to expand the 6-chloro-3,4-dihydro-1H-quinolin-2-one fragment towards the prime side to yield molecules with less hydrophilicity shows promise to afford potent, selective and orally bioavailable compounds.
The effectiveness and safety of recombinant human LH to support follicular development induced by recombinant human FSH in WHO group I anovulation: evidence from a multicentre study in Spain (2001)

This study confirms that combined rFSH and rLH treatment induces follicular growth, ovulation and pregnancy in a good proportion of hypogonadotrophic anovulatory patients and is well tolerated. The doses of 150 IU rFSH and 75 IU rLH daily seem the most appropriate but in a small minority of patients doses >75 IU rLH/day may be necessary.
Macrophage Scavenger Receptor 1 (Msr1, SR-A) Influences B Cell Autoimmunity by Regulating Soluble Autoantigen Concentration (2013)

The class A macrophage scavenger receptor Msr1 (SR-A, CD204) has been reported to participate in the maintenance of immunological tolerance. We investigated the role of Msr1 in a mouse model of autoantibody-dependent arthritis. Genetic deficiency of Msr1 in K/BxN TCR transgenic mice decreased the incidence and severity of arthritis because of decreased autoantibody production. Despite normal initial activation of autoreactive CD4(+) T cells, potentially autoreactive B cells in Msr1(-/-) K/BxN mice retained a naive phenotype and did not expand. This was not due to an intrinsic B cell defect. Rather, we found that macrophages lacking Msr1 were inefficient at taking up the key autoantigen glucose-6-phosphate isomerase and that Msr1-deficient mice had elevated serum concentrations of glucose-6-phosphate isomerase. Arthritis developed normally when bone marrow from Msr1(-/-) K/BxN mice was transplanted into hosts whose macrophages did express Msr1. Thus, Msr1 can regulate the concentration of a soluble autoantigen. In this model, the absence of Msr1 led to higher levels of soluble autoantigen and protected mice from developing pathogenic autoantibodies, likely because of altered cognate interactions of autoreactive T and B cells with impaired differentiation of follicular Th cells.
Capillary zone electrophoresis with laser-induced fluorescence detection for the determination of nanomolar concentrations of noradrenaline and dopamine: application to brain microdialyzate analysis (1995)

Determination of catecholamines by capillary zone electrophoresis with laser-induced fluorescence detection was performed on low-concentration samples, which were derivatized with naphthalene-2,3-dicarboxaldehyde to give highly fluorescent compounds. When the borate concentration in the derivatization medium was decreased from 130 to 13 mM, sensitivity for noradrenaline (NA) and dopamine (DA) was greatly enhanced while resolution between these two compounds decreased. A 50 mM borate concentration in derivatization medium was chosen since it provided maximal resolution between NA and DA, together with a high separation efficiency (3.1 million theoretical plates per meter for DA). The injection of 2.4 nL of a NA and DA solution derivatized at 10(-9) M produced peaks with signal-to-noise ratio of 8:1 and 3:1, respectively, corresponding to 1.8 amol of each catecholamine. The calibration curves were linear when NA and DA solutions were derivatized at concentrations ranging from 10(-6) to 10(-9) M. This method was used to determine NA in brain extracellular fluid: a peak corresponding to a basal level of 5 x 10(-9) M endogeneous NA was observed in microdialysates from the medial frontal cortex of the rat, and its nature was confirmed by both electrophoretic and pharmacological validations.
Design of Composite Right/Left-Handed Coplanar-Waveguide Bandpass and Dual-Passband Filters (2006)

The design and implementation of novel coplanar-waveguide (CPW) bandpass and dual-passband filters that consist of the composite right/left-handed short-circuited stubs are proposed. In contrast to the conventional short-circuited stub, whose input impedance repeats every half-wavelength, the composite right/left-handed CPW stub combines the phase-lead composite right/left-handed CPW and the phase-lag uniform CPW to achieve the arbitrary resonant frequencies with compact size. The equivalent bandpass and dual-passband LC resonators are established by investigating the frequency responses of the composite right/left-handed CPW stubs. The composite right/left-handed CPW bandpass filter is 62.5% more compact than the conventional quarter-wavelength shunt-stub CPW bandpass filter. The composite right/left-handed CPW dual-passband filter, which possesses the sharp rejection between the two asymmetric passbands, is also developed. The synthesis procedures of the composite right/left-handed CPW bandpass and dual-passband filters are successfully validated by measurement and full-wave simulation
Meet In the Middle Cross-Layer Adaptation for Audiovisual Content Delivery (2007)

This paper describes a new architecture and implementation of an adaptive streaming system (e.g., television over IP, video on demand) based on cross-layer interactions. At the center of the proposed architecture is the meet in the middle concept involving both bottom-up and top-down cross layer interactions. Each streaming session is entirely controlled at the RTP layer where we maintain a rich context that centralizes the collection of (i) instantaneous network conditions measured at the underlying layers (i.e.: link, network, and transport layers) and (ii) user- and terminal-triggered events that impose new real-time QoS adaptation strategies. Thus, each active multimedia session is tied to a broad range of parameters, which enable it to coordinate the QoS adaptation throughout the protocol layers and thus eliminating the overhead and preventing counter-productiveness among separate mechanisms implemented at different layers. The MPEG-21 framework is used to provide a common support for implementing and managing the end-to-end QoS of audio/video streams. Performance evaluations using peak signal to noise ratio (PSNR) and structural similarity index (SSIM) objective video quality metrics show the benefits of using the proposed Meet In the Middle cross-layer design compared to traditional media delivery approaches.
Efficacy of clozapine therapy in aggression (1998)

Object: Migration is one of the most important problems ofTurkey. 30.000 people are estimated to migrate to Adana from poor eastern villages per month. This study aimed to assess depression, anxiety and self-esteem in children, whose families had migrated from eastern region to Adana.