gebhart/patrepeval huggingface dataset:
Mechanisms of Synaptic Plasticity in the Dorsal Cochlear Nucleus: Plasticity-Induced Changes That Could Underlie Tinnitus (2008)

Here we review recent findings on cellular mechanisms observed in the DCN that can lead to long-term changes in the synaptic strength between different neurons in the DCN. These cellular mechanisms could provide candidate signaling pathways underlying the induction (ignition) and/or the expression (maintenance) of tinnitus.
Intracoronary Infusion of Reduced Glutathione Improves Endothelial Vasomotor Response to Acetylcholine in Human Coronary Circulation (1998)

The results indicate that GSH improved coronary endothelial vasomotor function, particularly in subjects with coronary risk factors, and it potentiated the vasodilator effect of nitroglycerin in human coronary arteries.
A blendshape model for mapping facial motions to an android (2007)

An important part of natural, and therefore effective, communication is facial motion. The android Repliee Q2 should therefore display realistic facial motion. In computer graphics animation, such motion is created by mapping human motion to the animated character. This paper proposes a method for mapping human facial motion to the android. This is done using a linear model of the android, based on blendshape models used in computer graphics. The model is derived from motion capture of the android and therefore also models the android's physical limitations. The paper shows that the blendshape method can be successfully applied to the android. Also, it is shown that a linear model is sufficient for representing android facial motion, which means control can be very straightforward. Measurements of the produced motion identify the physical limitations of the android and allow identifying the main areas for improvement of the android design.
Rosacea: Classification and Treatment (1997)

Rosacea is a chronic skin disorder affecting the facial convexities, characterized by frequent flushing, persistent erythema, and telangiectases. During episodes of inflammation additional features are swelling, papules and pustules. The disease was originally called acne rosacea, a misleading term that unfortunately persists1. Rosacea is a common disease, especially in fair-skinned people of Celtic and northern European heritage; it has been called the curse of the Celts. It is rare in American and African blacks2. Women are more often affected than men, but they seldom suffer the gross tissue and sebaceous gland hyperplasia of rhinophyma. Onset is usually between ages 30 and 50. In a recent epidemiological study the prevalence was 10%, most of the patients having only a red face3. In young patients especially, there may be a history of acne and the conditions may coexist.
The concept of plasma cleaning in glow discharge spectrometry (2009)

A plasma cleaning procedure to improve elemental depth profiling of shallow layered materials by glow discharge spectrometry is proposed. The procedure is based on two approaches applied prior to depth profiling, either individually or sequentially. The first approach employs a plasma generated at low power, i.e. a “soft” plasma, for removal of contaminants adsorbed on the surface of the target material. In the second approach, sacrificial material is sputtered under normal conditions, e.g. those used for depth profiling, to clean the inner surface of the anode of the glow discharge source. It is demonstrated that plasma cleaning in glow discharge optical emission spectrometry and glow discharge time-of-flight mass spectrometry improves significantly the spectrum of the target material, particularly at the commencement of sputtering due to stabilisation of the plasma as a result of removal of contaminants. Furthermore, modelling and validation studies confirmed that the soft plasma cleaning does not sputter the target material.
Grb-2-Associated Binder-1 Is Involved in Insulin-Induced <i>egr-1</i> Gene Expression through its Phosphatidylinositol 3′-Kinase Binding Site (2001)

The Grb2-associated binder-1 (Gab1) is one of the major adapter molecules downstream of growth factor receptor signaling. Even though insulin causes tyrosine phosphorylation of Gab1, its role in insulin signaling has not been identified yet. We have demonstrated that insulin increased expression of early growth response gene-1 (egr-1), which is one of the most important transcription factors involved in cell proliferation and differentiation. In the present study, the possible role of Gab1 in insulin-induced egr-1 expression was studied using Rat1 fibroblasts expressing human insulin receptors and wildtype Gab1 (HIRc/Gab1(WT)), Gab1 with three tyrosines in the phosphatidylinositol (PI) 3'-kinase binding domain mutated to phenylalanine (HIRc/Gab1(DeltaPI3K)), or histidinol resistance only (HIRc/HIS). Insulin-induced egr-1 expression in HIRc/Gab1(DeltaPI3K) cells was much lower than in the other cells, as determined by Northern blot analysis. These results suggest that Gab1 is involved in the signaling pathway for insulin-induced egr-1 expression through increasing PI3'-kinase activity. The MAP kinase activity increased less with insulin treatment in HIRc/Gab1(DeltaPI3K) cells than in other cells. Inhibition of MAP kinase by the MEK inhibitor completely abolished insulin-induced egr-1 expression. These results suggest that Gab1 increases MAP kinase activity through its PI3'-kinase binding site, which then leads to egr-1 expression. Our results indicate that Gab1 is involved in the control of egr-1 expression regulated by insulin.
Facility provision using mobile agents (2002)

In our opinion, a mobile user should be able to move seamlessly between networked sites on the Internet without having to care about how the same kind of facility is offered at different sites. We look at how mobile agent technology may be used to support user mobility. In our solution, a mobile agent travels ahead of the mobile user and therefore has the ability to prepare for the arrival of a mobile user at a visiting site. Our mobile agent will discover the facilities the mobile user wants to use. The mobile agent will bring along the mobile users personal preferences regarding e.g. the look-and-feel of the facilities. Some available solutions which support user mobility (e.g Jini), provide proxies through which facilities may be utilized. This requires dedicated operating systems (OS) or rigorous infrastructures at the mobile computing entity (MCE) for piping the service requests from the MCE to the provided facility. The solution we provide, aims at enabling the MCE to utilize the provided facilities by adapting the MCE OS to the provided facilities.
Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians (2009)

Our data support that alcohol sensitivity in Caucasians is genetically determined and suggest that a histamine-releasing effect of acetaldehyde represents a plausible biological mechanism. Furthermore, we present the first report of a clinically significant SNP within the acetaldehyde-metabolizing system in a Caucasian population.
Experiments of Hurricane Initialization with Airborne Doppler Radar Data for the Advanced Research Hurricane WRF (AHW) Model (2009)

Abstract Initialization of the hurricane vortex in weather prediction models is vital to intensity forecasts out to at least 48 h. Airborne Doppler radar (ADR) data have sufficiently high horizontal and vertical resolution to resolve the hurricane vortex and its imbedded structures but have not been extensively used in hurricane initialization. Using the Weather Research and Forecasting (WRF) three-dimensional variational data assimilation (3DVAR) system, the ADR data are assimilated to recover the hurricane vortex dynamic and thermodynamic structures at the WRF model initial time. The impact of the ADR data on three hurricanes, Jeanne (2004), Katrina (2005) and Rita (2005), are examined during their rapid intensification and subsequent weakening periods before landfall. With the ADR wind data assimilated, the three-dimensional winds in the hurricane vortex become stronger and the maximum 10-m winds agree better with independent estimates from best-track data than without ADR data assimilation. Through the multivariate incremental structure in WRF 3DVAR analysis, the central sea level pressures (CSLPs) for the three hurricanes are lower in response to the stronger vortex at initialization. The size and inner-core structure of each vortex are adjusted closer to observations of these attributes. Addition of reflectivity data in assimilation produces cloud water and rainwater analyses in the initial vortex. The temperature and moisture are also better represented in the hurricane initialization. Forty-eight-hour forecasts are conducted to evaluate the impact of ADR data using the Advanced Research Hurricane WRF (AHW), a derivative of the Advanced Research WRF (ARW) model. Assimilation of ADR data improves the hurricane-intensity forecasts. Vortex asymmetries, size, and rainbands are also simulated better. Hurricane initialization with ADR data is quite promising toward reducing intensity forecast errors at modest computational expense.
Colorimetric Enzymatic Determination of Serum Total Carbon Dioxide, as Applied to the Vickers Multichannel 300 Discrete Analyzer (1975)

Phosphoenolpyruvate carbosylase (EC 4.1.1.31) has been used in developing a simple, inexpensive colorimetric assay for serum total carbon dioxide in an open system. The oxaloacetate formed by the action of the enzyme on bicarbonate and phosphoenolpyruvate is measured by use of the diazonium salt of Fast Violet B. Interferences from billirubin, pyruvate, and drugs are negligible. Acetoacetate interference is significant only in highly ketotic samples, and a serum blank corrects for it. Serum protein interference is equivalent to 3.3 plus or minus 1.25 mmol of CO2 per liter and hence is sufficiently constant to be corrected for by use of a serum standard or serum blank. The method has been applied to the Vickers M-300 and D-300 systems and within-batch standard deviations of plus or minus 0.1 to plus or minus 0.6 mmol/liter have been observed. Excellent correlation with orthodox techniques has been obtained.
Structure-Activity Relationships of New Taxoids Derived from 14.beta.-Hydroxy-10-deacetylbaccatin III (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-Activity Relationships of New Taxoids Derived from 14.beta.-Hydroxy-10-deacetylbaccatin IIIIwao Ojima, Young Hoon Park, Chung-Ming Sun, Ivana Fenoglio, Giovanni Appendino, Paula Pera, and Ralph J. BernackiCite this: J. Med. Chem. 1994, 37, 10, 1408–1410Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/jm00036a004https://doi.org/10.1021/jm00036a004research-articleACS PublicationsRequest reuse permissionsArticle Views281Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Community detection in general stochastic block models: fundamental limits and efficient recovery algorithms (2015)

New phase transition phenomena have recently been discovered for the stochastic block model, for the special case of two non-overlapping symmetric communities. This gives raise in particular to new algorithmic challenges driven by the thresholds. This paper investigates whether a general phenomenon takes place for multiple communities, without imposing symmetry. In the general stochastic block model $\text{SBM}(n,p,Q)$, $n$ vertices are split into $k$ communities of relative size $\{p_i\}_{i \in [k]}$, and vertices in community $i$ and $j$ connect independently with probability $\{Q_{i,j}\}_{i,j \in [k]}$. This paper investigates the partial and exact recovery of communities in the general SBM (in the constant and logarithmic degree regimes), and uses the generality of the results to tackle overlapping communities. The contributions of the paper are: (i) an explicit characterization of the recovery threshold in the general SBM in terms of a new divergence function $D_+$, which generalizes the Hellinger and Chernoff divergences, and which provides an operational meaning to a divergence function analog to the KL-divergence in the channel coding theorem, (ii) the development of an algorithm that recovers the communities all the way down to the optimal threshold and runs in quasi-linear time, showing that exact recovery has no information-theoretic to computational gap for multiple communities, in contrast to the conjectures made for detection with more than 4 communities; note that the algorithm is optimal both in terms of achieving the threshold and in having quasi-linear complexity, (iii) the development of an efficient algorithm that detects communities in the constant degree regime with an explicit accuracy bound that can be made arbitrarily close to 1 when a prescribed signal-to-noise ratio (defined in term of the spectrum of $\diag(p)Q$) tends to infinity.
Transient-fault recovery using simultaneous multithreading (2003)

We propose a scheme for transient-fault recovery called Simultaneously, and Redundantly Threaded processors with Recovery (SRTR) that enhances a previously proposed scheme for transient-fault detection, called Simultaneously and Redundantly Threaded (SRT) processors. SRT replicates an application into two communicating threads, one executing ahead of the other. The trailing thread repeats the computation performed by the leading thread, and the values produced by the two threads are compared. In SRT a leading instruction may commit before the check for faults occurs, relying on the trailing thread to trigger detection. In contrast, SRTR must not allow any leading instruction to commit before checking occurs, since a faulty instruction cannot be undone once the instruction commits. To avoid stalling leading instructions at commit while waiting for their trailing counterparts, SRTR exploits the time between the completion and commit of leading instructions. SRTR compares the leading and trailing values as soon as the trailing instruction completes, typically before the leading instruction reaches the commit point. To avoid increasing the bandwidth demand on the register file for checking register values, SRTR uses the register value queue (RVQ) to hold register values for checking. To reduce the bandwidth pressure on the RVQ itself SRTR employs dependence-based checking elision (DBCE). By reasoning that faults propagate through dependent instructions, DBCE exploits register (true) dependence chains so that only the last instruction in a chain uses the RVQ, and has the leading and trailing values checked. SRTR performs within 1% and 7% of SRT for SPEC95 integer and floating-point programs, respectively. While SRTR without DBCE incurs about 18% performance loss when the number of RVQ ports is reduced from four (which is performance-equivalent to an unlimited number) to two ports, with DBCE, a two-ported RVQ performs within 2% of a four-ported RVQ.
Visceral glomerular epithelial cells can proliferate in vivo and synthesize platelet-derived growth factor B-chain. (1993)

In glomerular diseases associated with antibody- and complement-mediated injury to endothelial and mesangial cells, cell proliferation is an important early response that precedes matrix accumulation and glomerulosclerosis. In contrast, in diseases in which the visceral glomerular epithelial cell (vGEC) is the principal target of injury, cell proliferation is not a recognized consequence, although vGECs respond in vitro to a variety of growth factors and inflammatory mediators. To explore the possibility that low levels of vGEC proliferation may occur and participate in such diseases, serial studies were done in the passive Heymann nephritis model of membranous nephropathy, in which the vGEC is the primary target of antibody- and C5b-9-mediated injury. The results showed mitotic figures and positive staining for the proliferating cell nuclear antigen in cells whose location defined them as vGECs. The proliferating cell nuclear antigen-positive cells at the edge of the capillary wall were confirmed to be vGECs by double-immunostaining with antibodies to SPARC/osteonectin, which preferentially label vGECs in passive Heymann nephritis. Proliferation of vGECs in vivo was preceded by increased glomerular expression of platelet-derived growth factor (PDGF) B-chain protein and messenger RNA, both of which localized to vGECs. PDGF B-chain protein and messenger RNA were also detected in cultured vGECs. PDGF receptor beta-subunit protein or messenger RNA could not be demonstrated in vGECs in vivo or in vitro, and no growth response of cultured vGECs to PDGF was noted. These results suggest that proliferation of vGECs does occur in a model of glomerular injury induced by antibody and C5b-9 on vGECs. VGEC proliferation and production of PDGF may be involved in the restoration of the capillary wall but could also contribute to local capillary wall injury and proliferation of other cells in Bowman's capsule, interstitium, and tubules.
Synthesis and reaction of cyanopyridone derivatives and their potential biological activities. (1999)

4-Carboxy-3-cyano-6-biphenyl-pyrid-2-one (1) was prepared and then allowed to react with methyliodide, benzenesulphonyl chloride, phenylisothiocyanate, acetic anhydride, o-phenylenediamine, phenylmagnesium bromide and phosphorus pentasulphide affording the corresponding N-substituted pyrid-2-one 2-5, 4-(benzimidazol-2-yl)-pyrid-2-one 7, 2-hydroxy-2-phenyl-1,2-dihydro-pyridine 8 and 2-thiopyridone 9 derivatives, respectively. Treatment of 1 with dimethyl sulphate and phosphorus oxychloride to give 2-methoxy pyridine 12 and 2-chloro pyridine 13 derivatives. Reaction of 13 with amines and hydrazine hydrate afforded 14 and 15, respectively. The structural assignments of the new compounds were based on analytical, spectroscopic measurements and chemical reactions. Some of the obtained compounds showed interesting antibacterial and antifungal activities in vitro.
A rigid spirocyclic diol from fructose-based 5-hydroxymethylfurfural: synthesis, life-cycle assessment, and polymerization for renewable polyesters and poly(urethane-urea)s (2019)

Fructose based rigid diol with a spirocyclic structure and low GHG emission profile toward high performance biopolymers.
Tissue Expression and Immunolocalization of Tumor Necrosis Factor-α in Postinfarction Dysfunctional Myocardium (1999)

TNF-alpha is present early in a model of large myocardial infarction and is sustained into the later stage within the myocardium. Expression of this cytokine is not only confined strictly to the infarct or peri-infarct zone but is expressed by cardiac myocytes within the myocardium contralateral to the infarct. Therefore TNF-alpha production forms a part of an important intrinsic myocardial stress response system to injury.
Electric ticket-reserving system (1950)

STEADILY increasing difficulties have marked the expansion of the reservation systems of railroads and air lines over the past two decades. This may in large part be due to the greater number of people traveling today, to the increased speed of the vehicles, and perhaps also to the efforts that the carriers have made in supplying a large variety of accommodations. A large railroad can provide 12 different types of space such as berths, club chairs, roomettes, and so forth, all of which must be recorded in the reservation department to assure that every available seat is sold and at the same time to prevent duplicate selling that would irritate to the passenger and endanger good public relations.
Phospholipids containing polyunsaturated fatty acyl groups are mitogenic for normal mouse mammary epithelial cells in serum-free primary cell culture. (1989)

Epithelial cells obtained by collagenase digestion of mammary glands from virgin BALB/c mice were cultured in collagen gels in serum-free basal medium containing insulin (10 micrograms/ml), to which lipids or growth factors were added. Synthetic phospholipids were added as liposomes. Dilinoleoyl phosphatidic acid or phosphatidylserine or epidermal growth factor stimulated multifold growth. The optimum mitogenic effect of the phospholipids was dependent upon the presence of a polyunsaturated fatty acid esterified to the sn-2 position of the glycerol moiety. Dilinoleoyl phosphatidylcholine also stimulated growth but was generally less stimulatory than phosphatidylserine or phosphatidic acid, and phosphatidylethanolamine did not stimulate growth. Studies using phospholipids radiolabeled in either the sn-2 fatty acyl group or the glycerol backbone showed that the relative effect of phospholipids on growth did not correlate directly with the extent of their incorporation into cellular lipid, indicating that phospholipid turnover was the more important determinant for mitogenesis. Analysis of phosphatidic acid-stimulated growth suggested that both cAMP-dependent and cAMP-independent pathways were involved. Thus, mitogenic phospholipids stimulate proliferation by activating (directly or indirectly) multiple growth-regulatory pathways in mammary epithelial cells.
An ocular dynamic study supporting the hypothesis that hypothyroidism is a treatable cause of secondary open-angle glaucoma. (1992)

To examine the hypothesis that glaucoma may be a manifestation of unrecognized hypothyroidism, we studied 25 consecutive patients with newly diagnosed hypothyroidism who presented to an endocrinology clinic. Using tonography and tonometry, we demonstrated a reduction in facility of outflow in the hypothyroid state. With treatment of the hypothyroidism alone there was a statistically significant improvement in facility of outflow, intraocular pressure and Po/C (p < 0.002). Our results support the hypothesis that secondary open-angle glaucoma may be a manifestation of hypothyroidism and that the glaucoma will resolve on treatment of the primary disease.
A realistic evaluation of consistency algorithms for replicated files (1988)

Data are often replicated in distributed systems to protect them against site failures and network malfunctions. When this is the case, an access policy must be chosen to insure that a consistent view of the data is always presented. Voting protocols guarantee consistency of replicated data in the presence of any scenario involving non-Byzantine site failures and network partitions. While Static Majority Consensus Voting protocols use static quorums, Dynamic Voting protocols, like Dynamic Voting and Lexicographic Dynamic Voting, dynamically adjust quorums to changes in the status of the network of sites holding the copies.The availabilities of replicated data managed by these three protocols are compared using a simulation model with realistic parameters. Dynamic Voting is found to perform better than Majority Consensus Voting for all files having more than three copies while Lexicographic Dynamic Voting performs much better than the two other protocols for all eleven configurations under study.