gebhart/patrepeval huggingface dataset:
A 100 MHz 2-D 8×8 DCT/IDCT processor for HDTV applications (1995)

This paper discusses the design of a combined DCT/IDCT CMOS integrated circuit for real time processing of HDTV signals. The processor operates on 8/spl times/8 blocks. Inputs include the blocked pixels that are scanned one pixel at a time, and external control signals that control the forward or inverse modes of operation. Input pixels have a precision of 9-b for the DCT and 12-b for the IDCT. The layout has been generated with a 0.8 /spl mu/m CMOS library using the Mentor Graphics GDT tools and measures under 10 mm/sup 2/. Critical path simulation indicates a maximum input sample rate of 100 MHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
What do you measure when you measure resistivity? (1992)

Resistivity measurement is a weighted averaging of local resistivities. We develop a formalism to calculate the weighting function, applying it to square van der Pauw samples and to linear and square four-point probe arrays. In each case, some regions of the sample are negatively weighted, but these regions can be reduced or eliminated by van der Pauw averaging. We discuss negative weighting, which we feel is responsible for spurious reports of superconductivity above room temperature. We show how a square four-point array can be more effective at measuring local resistivity than a linear one. Finally, we show how to apply our formalism to anisotropic materials.
Cobalt-Catalyzed Intermolecular [2 + 2 + 2] Cycloaddition for the Synthesis of 1,3-Cyclohexadienes (2008)

A cobalt(I)-catalyzed [2 + 2 + 2] cycloaddition reaction between an internal acceptor-substituted alkyne and a terminal alkene leads to the formation of regiochemically enriched polysubstituted 1,3-cyclohexadiene derivatives in acceptable yields when methyl butynoate is used, whereas regiochemically pure products are formed in good yields form phenyl propyonate. The concurrent cyclotrimerization reaction of the alkyne to the corresponding benzene derivative is dependent on the sterical bulk of the alkyne and is considerably reduced with the sterically more hindered alkyne.
CHEMICAL and STRUCTURAL APPROACHES to RATIONAL DRUG DESIGN (2020)

Chemical Approaches to Rational Drug Design Design, Synthesis and Antitumor Activity of an Inhibitor of Ribonucleotide Reductase, J.R. McCarthy and P.S. Sunkara. The Development of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors, A. Stern. The Development of Potent Angiotensin II Receptor Antagonists Using a Novel Peptide Pharmacophore Model, R.M. Keenan, J. Weinstock, J.C. Hempel, J.M. Samanen, D.T. Hill, N. Aiyar, E.H. Ohlstein, and R.M. Edwards. Endothelin Structure and Development of Receptor Antagonists, A.M. Doherty. Molecular Targeting Chemistry in Rational Drug Design, A. Fritzberg, L. Gustavson, M. Hylarides, and J. Reno. Structural Approaches to Rational Drug Design The Role of X-Ray Crystallography in Structure-Based Rational Drug Design, A. McPherson. Biocomputational Approaches to Protein-Based Drug Design, K. Prammer, M. Weiner, and T. Kieber-Emmons. Architecture and Design of Zinc Protein-Ligand Complexes, D.W. Christianson and A.M. Khoury Christianson. Design of Immunomodulatory Peptides Based on Active Site Structures, A.B. Mukherjee and L. Miele. Index.
Enhancing the absorption coefficient of a backed rigid frame porous layer by embedding circular periodic inclusions (2011)

The acoustic properties of a porous sheet of medium static air flow resistivity (around 10,000 N m s(-4)), in which a periodic set of circular inclusions is embedded and which is backed by a rigid plate, are investigated. The inclusions and porous skeleton are assumed motionless. Such a structure behaves like a multi-component diffraction grating. Numerical results show that this structure presents a quasi-total (close to unity) absorption peak below the quarter-wavelength resonance of the porous sheet in absence of inclusions. This result is explained by the excitation of a complex trapped mode. When more than one inclusion per spatial period is considered, additional quasi-total absorption peaks are observed. The numerical results, as calculated with the help of the mode-matching method described in this paper, agree with those calculated using a finite element method.
D603 DYNAMIC CHARACTERISTICS OF A SINGLE MAGNET SUSPENSION SYSTEM APPLIED TO A LOW-SPEED EMS MAGLEV VEHICLE (2003)

Based on a single magnet suspension system applied to a low-speed maglev vehicle in China, the suspension stiffness and damping characteristics are investigated. Theoretic analyses show that suspension stiffness and damping are directly proportional to the feedback gains of airgap and airgap velocity respectively. Then, considering a real two-level cascade control system, a dynamic model of the single magnet-guideway-controller coupling system is established. Simulation results of take-off dynamic response indicate that the system resonance will be easily excited if any two of the frequency of secondary suspension, the eigenfrequency of guideway and the frequency of electromagnetic suspension are too close.
Regulation of Connexin43 Expression by c-Fos and c-Jun in Myometrial Cells (2001)

Labor is associated with a dramatic increase in the myometrial expression of connexin43 (Cx43) which is thought to mediate myocyte contractile coupling. The transcription factor c-fos is also dramatically increased prior to the onset of labor and is therefore a potential regulator of Cx43. The promoter region of Cx43 contains a conserved activator protein-1 (AP-1) site, which binds dimers of Fos and Jun proteins. We constructed expression vectors for c-Fos and c-Jun to investigate the role of these transcription factors in the regulation of Cx43 expression. These expression vectors were then co-transfected into SHM (syrian hamster myocyte) cells with a Cx43 promoter-Luciferase vector. The combinations of c-Fos and c-Jun proteins activated the Cx43 promoter while c-Jun alone had no effect on Cx43 promoter activity. Mutation of the AP-1 site was found to reduce this responsiveness. These data indicate that the transcription factors c-Fos and c-Jun are important in the regulation of Cx43 expression.
The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. (1994)

The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B). In most cell contexts, hPR-B functions as a transcriptional activator of progesterone-responsive genes, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors. We have created mutations within the carboxyl terminus of hPR which differentially effect the transcriptional activity of hPR-B in a cell- and promoter-specific manner. Analogous mutations, when introduced into hPR-A, have no effect on its ability to inhibit the transcriptional activity of other steroid hormone receptors. The observed differences in the structural requirements for hPR-B and hPR-A function suggest that transcriptional activation and repression by PR are mediated by two separate pathways within the cell. In support of this hypothesis, we have shown that hPR-A mediated repression of human estrogen receptor (hER) transcriptional activity is not dependent on hER expression level but depends largely on the absolute expression level of hPR-A. Thus, it appears that hPR-A inhibits hER transcriptional activity as a consequence of a noncompetitive interaction of hPR-A with either distinct cellular targets or different contact sites on the same target. We propose that hPR-A expression facilitates a ligand-dependent cross-talk among sex steroid receptor signaling pathways within the cell. It is likely, therefore, that alterations in the expression level of hPR-A or its cellular target can have profound effects on the physiological or pharmacological responses to sex steroid hormone receptor ligands.
Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: evidence for the existence of a sphingosine phosphatase (1994)

On addition of [4,5-3H]sphinganine 1-phosphate to human fibroblast monolayers, the label was efficiently removed from the culture medium. In contrast with the reported stability of phosphorylated sphingenine in 3T3 cells [Desai, Zhang, Olivera, Mattie and Spiegel (1992). J. Biol. Chem. 267, 23122-23128] and B16 melanoma cells [Sadahira, Ruan, Hakomuri and Igarashi (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 9686-9690], sphinganine 1-phosphate appeared to be subjected to a fast and extensive metabolism in fibroblasts, the major pathways being cleavage and dephosphorylation. The first of these pathways, catalysed by sphingosine-phosphate lyase, resulted in the formation of labelled palmitaldehyde, which was recovered, mainly after oxidation, in glycerophospholipids in an ester bond. A smaller part of the palmitaldehyde was reduced and incorporated in alk(en)ylphospholipids. Dephosphorylation of spinganine 1-phosphate, a hitherto overlooked pathway catalysed by an unknown phosphatase(s), gave rise to sphinganine, which was converted by N-acylation into ceramide and then incorporated in spingomyelin and glycosphingolipids.
Comparison of acid‐induced conformation changes between 7S and 11S globulin in soybean seeds (1972)

Abstract The acid‐induced conformation changes between 7 and 11 S globulin, the major storage proteins in soybean seeds, were compared by ultraviolet difference spectra, ultracentrifugation and optical rotatory dispersion. Maximum denaturation occurred at approximately pH 2 in both and dissociation of the proteins into subunits and unfolding of the polypeptide chains were observed simultaneously. However, both proteins showed apparent differences in their readiness to undergo acid‐induced denaturation. The differences were particularly remarkable in the presence of 0.1 ionic strength sodium chloride.
Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH (2012)

During atherogenesis, the extracellular pH of atherosclerotic lesions decreases. Here, we examined the effect of low, but physiologically plausible pH on aggregation of modified LDL, one of the key processes in atherogenesis. LDL was treated with SMase, and aggregation of the SMase-treated LDL was followed at pH 5.5-7.5. The lower the pH, the more extensive was the aggregation of identically prelipolyzed LDL particles. At pH 5.5-6.0, the aggregates were much larger (size >1 µm) than those formed at neutral pH (100-200 nm). SMase treatment was found to lead to a dramatic decrease in α-helix and concomitant increase in β-sheet structures of apoB-100. Particle aggregation was caused by interactions between newly exposed segments of apoB-100. LDL-derived lipid microemulsions lacking apoB-100 failed to form large aggregates. SMase-induced LDL aggregation could be blocked by lowering the incubation temperature to 15°C, which also inhibited the changes in the conformation of apoB-100, by proteolytic degradation of apoB-100 after SMase-treatment, and by HDL particles. Taken together, sphingomyelin hydrolysis induces exposure of protease-sensitive sites of apoB-100, whose interactions govern subsequent particle aggregation. The supersized LDL aggregates may contribute to the retention of LDL lipids in acidic areas of atherosclerosis-susceptible sites in the arterial intima.
Monoclonal Antibodies Directed Against Human Fibroblast Interferon: Characterization and Functional Studies (1983)

Spleen cells from BALB/c mice, immunized with SDS-acrylamide gel purified human fibroblast interferon (HuIFN-β) were fused with mouse myeloma cells. Culture fluids from the resulting hybrid cells were screened for HuIFN-β specificity by the following tests: (1) a solid-phase RIA using partially purified HuIFN-β, (2) a protein-transfer RIA using electrophoretically resolved and immobilized HuIFN-β, and (3) a bioassay which tests residual HuIFN-β activity in the supernatant following immunoprecipitation. Six HuIFN-β-specific hybridomas were identified; two were capable of partially neutralizing HuIFN-β activity. All six antibodies bind to the β1-IFN polypeptide synthesized in E. coli cells containing a cloned β1-IFN DNA sequence. All six monoclonal antibodies were found to be IgG3/x.
A Proposed Intelligent Vehicle Telematics Service System (IVTS) (2006)

Location-based vehicle navigation services, monitoring services and traffic information services are three categories of transportation-related applications, and tend to converge at a new domain now, i.e., vehicle telematics. This paper addresses a uniform system, so-called intelligent vehicle telematics service system (IVTS). Firstly, the four-part structure is put forward, including traffic information collection sub-system, service centers (inc. traffic information center, map server and monitoring center), communication infrastructures and in-vehicle telematics terminal. Secondly, five related issues are discussed in detail respectively, that is, traffic information encoding, traffic-data-based dynamic route calculation, dynamic updating of navigable digital map, server-side multi-user response, and hardware terminal incorporation. Lastly, experimental systems are illustratively exhibited
Proton NMR and NOE Structural and Dynamic Studies of Larger Proteins and Nucleic Acids Aided by Isotope Labels: T4 Lysozyme (1987)

This article reviews methods based on direct observation of proton NMR in macromolecules containing 13C or 15N labels. The resonances and Overhauser effects of protons attached to the labels can be edited or filtered from the remaining overlapping resonances. This leads to simplification of the spectra when labels are incorporated selectively. In 2D and related methods the label's chemical shift provides a second dimension which is useful for spectral differentiation and identification. The methods are useful for larger proteins and we describe our progress on studies of T4 lysozyme, mass 18.7 kD, in which we have already identified a large number of resonances.
Multiwavelength InGaAs/InGaAsP strained-layer MQW-laser array using shadow-masked growth (1992)

A simple technique for fabricating multiwavelength laser arrays is presented. The lateral variations in bandgap (or emission wavelength) between the different lasers are obtained by the use of shadow-masked growth. The shadow masked growth results in variations in thickness (and to a lesser extent, in composition) over the substrate. In combination with a multiquantum well (MQW) active region, this gives the required bandgap variations. By varying the window width in the shadow mask between 10 mu m and >500 mu m it was possible to obtain a wavelength span of 130 nm centered around 1.55 mu m. The strained-layer-ridge MQW Fabry-Perot lasers showed a constant threshold current (around 70 mA for an 11- mu m*500- mu m stripe).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An analysis of the effects of mobility on bandwidth allocation strategies in multi-class cellular wireless networks (2002)

In this paper we present a multi-cell analytic model for multi-class cellular networks. We investigate the effects subscriber mobility has on bandwidth control strategies when the network supports multiple classes of subscribers having different bandwidth requirements. We introduce control strategies from non-mobile networks and examine them in a mobile environment. The expressions for call blocking using these control strategies have product form solutions. This allows us to develop a multi-cell, multi-class, model by generalizing on the Erlang fixed point approximation using generalized multi-rate, multi-class, Erlang loss formulas for each class of traffic. We produce expressions for originating calls lost, hand-off calls lost, forced-termination, and mean channel occupancy for each class of traffic in each cell for different control strategies. The multicell analytic model allows us to investigate the effects of asymmetric loads and mobility patterns in the network. The analytic results are supported by simulation.
Spectral response of InP/Si solar cells irradiated to high proton fluences (2002)

InP/Si solar cells have been irradiated with 3 MeV protons to very large fluences where carrier removal, instead of decreases in minority carrier diffusion length, dominates the radiation response. In this regime, radiation-induced expansion of the base depletion width causes I/sub sc/ to increase above the pre-irradiation level before falling catastrophically to zero. Current-voltage (IV), capacitance-voltage (CV), quantum efficiency (QE), and electrochemical capacitance-voltage (ECV) profiling measurements are presented.
Synthesis and pharmacological properties of some 7H-[1] benzothiopyrano-[3,2-c] quinolin-7-ones. (1983)

The title compounds 3a-d were prepared by intramolecular cyclization of 2-[S-(quinolyl-4)]-thiobenzoic acids 2a-d. The effects of 3a-d on the central nervous system were tested. Among the investigated benzothiopyranoquinolinones, the 2-chloro-6-methyl-derivative (3c) showed analgesic activity in the hot-plate and the writhing tests in doses over 100 mg/kg. Among known, biologically active polycyclic heterocyclic systems [1], benzothiopyranoquinolinones with variously condensed heterocyclic rings, have received little attention. 7H-[1] Benzothiopyrano [3,2-c] quinolin-7-one (3a) is an example of one of the four possible isomers in such systems. In continuation of our search for new centrally active compounds [12], we report here the synthesis and characterization of the parent system 3a and its three derivatives 3b-d. Since some thioxanthene derivatives [9] are known to be neuroleptic drugs, and few known in literature compounds [2, 13, 20] derived from the 3a system have not been tested pharmacologically for the central nervous system activity, we decided to investigate the influence of [1]-benzothiopyranoquinolinones 3a-d on the central nervous system of mice. The results of pharmacological screening are presented in this paper.
Methane-hydrogen III-V metal-organic reactive ion etching (1991)

A CH4/H2 gas mixture has been used for reactive ion etching of GaAs, GaP, GaSb, InP and GaInAsP in an effort to achieve slow, smooth, anisotropic mesa etching of micrometre to submicrometre structures without causing considerable surface damage or stoichiometric modifications to the etched compounds. Parametric effects have been studied to try to understand the etching mechanism.
Formation Damage and Fluid Loss Reduction due to Plastering Effect of Casing Drilling (2011)

Abstract The objective of this work is to investigate the influence of cuttings size in Casing Drilling to plug pores for fluid loss control, and thereby reducing formation damage. Historically, the emphasis of drilling operations has been to drill wells cheaply and quickly without much consideration for the resulting impact on well productivity. Formation damage occurs frequently and rapidly during drilling operations with potentially severe consequences. The Plastering Effect of Casing Drilling reduces solids and filtrate invasion, resulting in less skin damage and improved productivity. It also reduces formation damage due to cement filtrate by creating a gauged wellbore and proper casing/wellbore standoff. The Casing Drilling process grinds drill cuttings as they travel up the annulus and creates a larger particle size distribution (PSD) profile than conventional drilling operations. These finer cuttings are subsequently smeared into the wellbore face by the mechanical contact of the large diameter casing with the borehole wall. The result is a very high quality, tight, thin, almost impermeable mud cake that isolates the formation from the wellbore. Evidence shows that cement binds very well to this type of mud cake. The PSD analysis determined that the smaller size and wide range of Casing Drilling cuttings make it possible for these particles to readily adhere to the wellbore; this helps seal the pore spaces of the formation and prevent further solids and filtrate invasion. Pore throats can most effectively be plugged when the cuttings are in the proper micron size range as any possible gap between the mud and cuttings PSD can be covered by adding minimal amounts of properly sized lost circulation materials. Casing Drilling has proven to be a unique approach in mitigating formation damage due to the drilling process. One case study confirms that reservoir sections drilled with casing show enhanced productivity as much as twice the wells drilled conventionally. The Plastering Effect, as an inherent benefit of Casing Drilling, keeps the producing formation as intact as possible and reduces formation damage.
Revising User Profiles: The Search for Interesting Web Sites (1996)

We describe Syskill &amp; Webert, a software agent that learns to rate pages on the World Wide Web (WWW), deciding what pages might interest a user. The user rates explored pages on a three point scale, and Syskill &amp; Webert learns a user profile by analyzing the information on each page. We focus on an extension to Syskill &amp; Webert that lets a user provide the system with an initial profile of his interests in order to increase the classification accuracy without seeing many rated pages. We represent this user profile in a probabilistic way, which allows us to revise the profile as more training data is becoming available using &quot;conjugate priors&quot;, a common technique from Bayesian statistics for probability revision. Unseen pages are classified using a simple Bayesian classifier that uses the revised probabilities. We compare our approach to learning algorithms that do not make use of such background knowledge, and find that a user defined profile can significantly increase the classificati...
Ứng dụng WebGIS trong giám sát quản lý, sử dụng tài nguyên đất (2019)

Bài báo này giới thiệu kết quả xây dựng WebGIS do cơ quan quản lý đất đai cấp tỉnh quản lý, với 2 chức năng chính là cung cấp các thông tin về đất đai và tiếp nhận các phản ánh của người dân, cộng đồng về các vi phạm trong quản lý, sử dụng đất, các thông tin về tai biến tự nhiên trên đất. Các thông tin cung cấp của người dân và cộng đồng là những nội dung theo đúng quy định của pháp luật trong thực hiện các quyền giám sát và hỗ trợ hoạt động giám sát của cơ quan quản lý. WebGIS có địa chỉ http://tainguyendat-quangninh.vn bước đầu thực nghiệm cho thành phố Uông Bí tỉnh Quảng Ninh. WebGIS được thiết kế công cụ đồ họa để người dân và cộng đồng khoanh vẽ khu vực xảy ra vi phạm kèm theo các thông tin, hình ảnh, video. Đây là một công cụ hỗ trợ hiệu quả trong quản lý nhà nước về đất đai.