gebhart/patrepeval huggingface dataset:
[Cylindrical osteotomy of the upper extremity of the tibia with advancement of the patellar ligament. Biomechanical treatment of gonarthrosis]. (1975)

The authors recall briefly the applications of Pauwel's theories concerning surgery in cases of gonarthrosis, which must be surgery to relieve restrictions on movement and not surgery to restore shape. They describe briefly the main biomechanical principles which must guide the pre-operative investigations and report their experience with a technique proposed by Blaimont and perfected by Maquet, the advantage of which is the exactness of the surgical correction. The technique is also useful in cases of femoro-patellar arthrosis. Among 120 osteotomies carried out using this method, the authors obtained very good or good results in 85 per cent of cases, and fairly good or poor results in 15 per cent of the patients. This method makes it possible to avoid in the great majority of cases recourse to total prostheses of the knee.
A high-frequency CMOS linear transconductance element (1986)

A simple four-transistor, linear, tunable, high-frequency transconductance element is described. By using a pair of composite <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</tex> -channel- <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</tex> -channel devices, the circuit achieves its linearity by current differencing without undue matching requirements. It is shown that linearity and frequency response can be optimized simultaneously by appropriate choice of device dimensions. The performance is verified by SPICE simulations, and an operational transconductance amplifier (OTA) is used as one example for the many applications of the proposed element.
Enhancement of Photocathode Sensitivity by Total Internal Reflection as Applied to an Image Tube (1966)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text W. C. Livingston, "Enhancement of Photocathode Sensitivity by Total Internal Reflection as Applied to an Image Tube," Appl. Opt. 5, 1335-1336 (1966) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Evaluation of a commercially available vaccine against Corynebacterium pseudotuberculosis for use in sheep. (1998)

To evaluate the efficacy of a commercially available bacterin-toxoid vaccine for preventing Corynebacterium pseudotuberculosis-induced abscesses in sheep.Prospective randomized controlled trial.31 mixed-breed sheep seronegative for C pseudotuberculosis.Sheep were randomly assigned to vaccinate (n = 20) or nonvaccinate (11; control) groups. Sheep in the vaccinate group received 2 doses of serial A or serial B bacterin-toxoid vaccine at 4-week intervals. Serologic testing was conducted after vaccination to document an antibody response to vaccination. All sheep were challenge inoculated with virulent C pseudotuberculosis organisms 32 weeks after the second vaccination. Twenty weeks after challenge inoculation, all sheep were examined for external and internal abscesses secondary to C pseudotuberculosis infection.Vaccinated sheep developed an antibody response to both components of the vaccine, as measured by use of ELISA tests. After challenge inoculation, vaccinated sheep had significantly less external, internal, and total abscesses than control sheep.Vaccination of sheep with a commercially available bacterin-toxoid against C pseudotuberculosis could substantially decrease the prevalence and number of abscesses that form secondary to C pseudotuberculosis infection.
Computerised linking of medical records: methodological guidelines. (1993)

Probability matching, using an array of identifiers, achieves much higher levels of correct matching than is generally achievable by exact character by character comparisons. The increasing use of information technology to store data about health and health care means that there is increasing scope to link records for research and for patient care. Sophisticated methods to achieve this on a large scale are now available.
RNA-Guided Recombinase-Cas9 Fusion Targets Genomic DNA Deletion and Integration (2019)

CRISPR-based technologies have become central to genome engineering. However, CRISPR-based editing strategies are dependent on the repair of DNA breaks via endogenous DNA repair mechanisms, which increases susceptibility to unwanted mutations. Here we complement Cas9 with a recombinase's functionality by fusing a hyperactive mutant resolvase from transposon Tn3, a member of serine recombinases, to a catalytically inactive Cas9, which we term integrase Cas9 (iCas9). We demonstrate iCas9 targets DNA deletion and integration. First, we validate iCas9's function in <i>Saccharomyces cerevisiae</i> using a genome-integrated reporter. Cooperative targeting by CRISPR RNAs at spacings of 22 or 40 bp enables iCas9-mediated recombination. Next, iCas9's ability to target DNA deletion and integration in human HEK293 cells is demonstrated using dual GFP-mCherry fluorescent reporter plasmid systems. Finally, we show that iCas9 is capable of targeting integration into a genomic reporter locus. We envision targeting and design concepts of iCas9 will contribute to genome engineering and synthetic biology.
Adaptive extremal control (2002)

In this paper extremal control of a simple nonlinear stochastic system is analyzed. The process is modeled as a generalized Hammerstein model. Different problem formulations are discussed and the performances of the resulting nonlinear adaptive controllers are investigated. The adaptive controllers are based on online estimation of the parameters of the process and the certainty equivalence principle.
Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control. (1980)

Dendritic cells prepared by a modification of the method of Steinman and Cohn are I-A+ and FcR-. They are extremely potent at activating not only allogeneic T cell proliferation but also antigen-specific syngeneic T cell proliferation. Dendritic cells from nonresponder strains are unable to present antigens to responder X nonresponder T cells, suggesting that they may be a site of Ir gene product expression.
IL‐1β TNF‐α, and IL‐2 in Peritoneal Fluid and Macrophage‐Conditioned Media of Women With Endometriosis (1995)

This study supports the concept that endometriosis is associated with activation of peritoneal macrophages, and a higher concentration of these cells. This activation is reflected by the increased levels of cytokines found in macrophage conditioned media. The absence of significant changes in peritoneal fluid cytokine levels would seen to indicate that the above derangements are not responsible for the development or progression of endometriosis.
The Peptidyl-Prolyl Isomerase Motif Is Lacking in PmpA, the PrsA-Like Protein Involved in the Secretion Machinery of <i>Lactococcus lactis</i> (2002)

The prsA-like gene from Lactococcus lactis encoding its single homologue to PrsA, an essential protein triggering the folding of secreted proteins in Bacillus subtilis, was characterized. This gene, annotated pmpA, encodes a lipoprotein of 309 residues whose expression is increased 7- to 10-fold when the source of nitrogen is limited. A slight increase in the expression of the PrsA-like protein (PLP) in L. lactis removed the degradation products previously observed with the Staphylococcus hyicus lipase used as a model secreted protein. This shows that PmpA either triggers the folding of the secreted lipase or activates its degradation by the cell surface protease HtrA. Unlike the case for B. subtilis, the inactivation of the gene encoding PmpA reduced only slightly the growth rate of L. lactis in standard conditions. However, it almost stopped its growth when the lipase was overexpressed in the presence of salt in the medium. Like PrsA of B. subtilis and PrtM of L. lactis, the L. lactis PmpA protein could thus have a foldase activity that facilitates protein secretion. These proteins belong to the third family of peptidyl-prolyl cis/trans-isomerases (PPIases) for which parvulin is the prototype. Almost all PLP from gram-positive bacteria contain a domain with the PPIase signature. An exception to this situation was found only in Streptococcaceae, the family to which L. lactis belongs. PLP from Streptococcus pneumoniae and Enterococcus faecalis possess this signature, but those of L. lactis, Streptococcus pyogenes, and Streptococcus mutans do not. However, secondary structure predictions suggest that the folding of PLP is conserved over the entire length of the proteins, including the unconserved signature region. The activity associated with the expression of PmpA in L. lactis and these genomic data show that either the PPIase motif is not necessary for PPIase activity or, more likely, PmpA foldase activity does not necessarily require PPIase activity.
Protein Microarrays with Novel Microfluidic Methods: Current Advances (2014)

Microfluidic-based micromosaic technology has allowed the pattering of recognition elements in restricted micrometer scale areas with high precision. This controlled patterning enabled the development of highly multiplexed arrays multiple analyte detection. This arraying technology was first introduced in the beginning of 2001 and holds tremendous potential to revolutionize microarray development and analyte detection. Later, several microfluidic methods were developed for microarray application. In this review we discuss these novel methods and approaches which leverage the property of microfluidic technologies to significantly improve various physical aspects of microarray technology, such as enhanced imprinting homogeneity, stability of the immobilized biomolecules, decreasing assay times, and reduction of the costs and of the bulky instrumentation.
Influence of S and Se on the Schottky-barrier height and interface chemistry of Au contacts to GaAs (1985)

The electrical properties and interface chemistry of Au Schottky-barrier contacts formed on n-type GaAs (100) surfaces that had prior exposure (at room temperature) to elemental S or Se are compared to those of Au contacts to clean surfaces (ideal contacts). The interface Fermi-level energy EiF and chemistry during contact formation were investigated by x-ray photoemission spectroscopy (XPS). The Schottky-barrier height φB was measured by current-voltage and capacitance-voltage methods on the same interfaces characterized by XPS. The exposure of clean GaAs to elemental S or Se results in formation of a ∼5 Å surface layer of Ga and As chalcogenides via a limited chemical reaction. The Schottky-barrier height for Au contacts to the S or Se exposed surfaces had a 0.2 eV variation (0.8–1.0 eV) centered about the φB=0.89 eV value for the ideal Au contact. Changes in EiF over a ∼0.4 eV range occur in response to changes in interface chemistry during surface treatment sequences that include S and Se exposure and Au deposition.
Sorting of Human Peripheral Blood T-Cell Subsets Using Immunomagnetic Beads (1998)

Immunomagnetic beads are uniform, polymer particles coated with a polystyrene shell that provides both a smooth, hydrophobic surface to facilitate absorption of molecules, such as antibodies, and surface hydroxyl groups that allow covalent chemical binding of other bioreactive molecules, such as streptavidin, lectins, and peptides. Iron (III) oxide (Fe2O3) deposited in the core gives the beads superparamagnetic properties that lead to consistent and reproducible reactions to a magnetic field without permanent magnetization of the particles. These are the two qualities on which immunomagnetic separation (IMS) depends.
The query execution engine in Tandem's new ServerWare SQL product (2002)

Tandem has re-written its SQL compiler and its query execution engine into a new product that will be available on multiple operating systems. The new product uses a novel query execution engine and the authors highlight the unique aspects of the new engine. ServerWare SQL uses a data flow and scheduler driven task model to execute queries. Tasks communicate either via in-memory queues or via interprocess communication. Partitioned, pipelined, or independent operations are executed in parallel. By adding new task types the model can be easily extended. Parallelism in a distributed memory environment is implemented as a special "exchange" task type, as in the Volcano research prototype. Scheduling and load balancing are performed by separate scheduler tasks.
Split-Transactions for Open-Ended Activities (1988)

Open-ended activities such as CAD/Cam, VLSI layout and software development require consistent concurrent access and fault tolerance associated with database transactions, but their uncertain duration, uncertain developments during execution and long interaction with other concurrent activities break traditional transaction atomicity boundaries. We propose split-transaction as a new database operation that solves the above problems by permitting transactions to commit data that will not change. Thus an open-ended activity can release the committed data and serialize interactions with other concurrent activities through the committed data. This technical report was originally titled Support of Multiuser Software Development Environments.
High Rate Ion Production for Vacuum Deposition (1972)

A high current, low voltage magnetically confined and bent hot hollow cathode discharge was used to simultaneously evaporate and to ionize materials under vacuum. At power levels of about 15 kW, (60V, 250A) evaporation rates of 4 g/min were observed for copper and quartz from a 3 in. diam water-cooled crucible. Two 6×6 in. substrates were mounted symmetrically 20 in. above the source one being at crucible (ground) potential, the other having a negative bias voltage (0–200 V) in order to collect ions. At a given evaporation rate, the biased substrate collected about twice as much copper and about five times the amount of quartz as that deposited upon the grounded substrate.
D-104 Inverse Analysis of Neutron Diffraction Data (2007)

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Hitting the limit of magnetic anisotropy (2014)

Enhancing the magnetic properties of adatoms provides a route toward atom-scale memory [Also see Report by Rau et al. ]
Case 34-2009 (2009)

A 20-year-old man was admitted to this hospital because of sore throat, fever, and a diffuse rash for 1 week. Testing for streptococcal pharyngitis and mononucleosis was negative. Amoxicillin and clavulanate were prescribed, and the next day, a red, itchy rash developed on the medial surface of his right arm; the lesions became raised, enlarged, and painful and spread from his arms to his legs, back, hands, feet, and perioral area, without mucosal involvement. Examination disclosed a diffuse eruption of tender violaceous-pink papulovesicles, which progressed to hemorrhagic crusting. A diagnostic procedure was performed.
Genetic Analysis of Mouse Embryonic Stem Cells Bearing <i>Msh3</i> and <i>Msh2</i> Single and Compound Mutations (2000)

We have previously described the use of homologous recombination and CRE-loxP-mediated marker recycling to generate mouse embryonic stem (ES) cell lines homozygous for mutations at the Msh3, Msh2, and both Msh3 and Msh2 loci (2). In this study, we describe the analysis of these ES cells with respect to processes known to be affected by DNA mismatch repair. ES cells homozygous for the Msh2 mutation displayed increased resistance to killing by the cytotoxic drug 6-thioguanine (6TG), indicating that the 6TG cytotoxic mechanism is mediated by Msh2. The mutation rate of the herpes simplex virus thymidine kinase 1 (HSV-tk1) gene was unchanged in Msh3-deficient ES cell lines but markedly elevated in Msh2-deficient and Msh3 Msh2 double-mutant cells. Notably, the HSV-tk1 mutation rate was 11-fold higher, on average, than that of the hypoxanthine-guanine phosphoribosyl transferase (Hprt) locus in Msh2-deficient cells. Sequence analysis of HSV-tk1 mutants from these cells indicated the presence of a frameshift hotspot within the HSV-tk1 coding region. Msh3-deficient cells displayed a modest (16-fold) elevation in the instability of a dinucleotide repeat, whereas Msh2-deficient and Msh2 Msh3 double-mutant cells displayed markedly increased levels of repeat instability. Targeting frequencies of nonisogenic vectors were elevated in Msh2-deficient ES cell lines, confirming the role of Msh2 in blocking recombination between diverged sequences (homeologous recombination) in mammalian cells. These results are consistent with accumulating data from other laboratories and support the current model of DNA mismatch repair in mammalian cells.
Collaborative localization of mobile users with Bluetooth (2012)

Location awareness is a key requirement for many pervasive applications. Collaborative localization can improve accuracy and coverage indoors and improve power consumption by duty-cycling GPS outdoors. We use Bluetooth for collaborative localization of mobile personal devices. Specifically, we embed information in Bluetooth device names to improve latency of information exchange between participating nodes. We identify and demonstrate on real hardware two problems in the Bluetooth stack that negatively impact localization accuracy: a) device name caching that introduces significant device-specific delays in transmitting information between nodes, and b) poor accuracy of time synchronization in modern mobile devices. Our solution is to append additional time information to the device name and track time offsets between nodes. We verify experimentally that this helps to both detect outliers and correct for time-synchronization errors and thus mitigate localization errors.
Direct current, alternating current, rapid, and inverse polarographic methods for determination of tin(IV) (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect current, alternating current, rapid, and inverse polarographic methods for determination of tin(IV)Alan M. BondCite this: Anal. Chem. 1970, 42, 11, 1165–1168Publication Date (Print):September 1, 1970Publication History Published online1 May 2002Published inissue 1 September 1970https://pubs.acs.org/doi/10.1021/ac60293a028https://doi.org/10.1021/ac60293a028research-articleACS PublicationsRequest reuse permissionsArticle Views116Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Role of Hydrogen Peroxide and Other Reactive Oxygen Species in Wound Healing (2011)

Wound healing is a complex physiological process important for tissue homeostasis. An acute injury initiates massive cell migration, proliferation and differentiation, synthesis of extracellular matrix components, scar formation and remodelling. Blood flow and tissue oxygenation are parts of the complex regulation of healing. Higher organisms utilize molecular oxygen as a terminal oxidant. This way of gaining energy for vital processes such as healing leads to the production of a number of oxygen compounds that may have a defensive or informatory role. They may be harmful when present in high concentrations. Both the lack and the excess of reactive oxygen species may influence healing negatively.
A CMOS IC for Gb/s Viterbi decoding: system design and VLSI implementation (1996)

At present, the Viterbi algorithm (VA) is widely used in communication systems for decoding and equalization. The achievable speed of conventional Viterbi decoders (VD's) is limited by the inherent nonlinear add-compare-select (ACS) recursion. The aim of this paper is to describe system design and VLSI implementation of a complex system of fabricated ASIC's for high speed Viterbi decoding using the "minimized method" (MM) parallelized VA. We particularly emphasize the interaction between system design, architecture and VLSI implementation as well as system partitioning issues and the resulting requirements for the system design flow. Our design objectives were 1) to achieve the same decoding performance as a conventional VD using the parallelized algorithm, 2) to achieve a speed of more than 1 Gb/s, and 3) to realize a system for this task using a single cascadable ASIC. With a minimum system configuration of four identical ASIC's produced by using 1.0 /spl mu/ CMOS technology, the design objective of a decoding speed of 1.2 Gb/s is achieved. This means, compared to previous implementations of Viterbi decoders, the speed is increased by an order of magnitude.
CpG oligonucleotide and α-d-mannose conjugate for efficient delivery into macrophages (2016)

For improved intracellular uptake of CpG ODN into macrophages, we developed CpG ODN and mannose conjugate (CpG–Man conjugate) via simple conjugation of α-d-mannose to CpG ODN. CpG–Man conjugate showed greatly enhanced intracellular uptake by 2.1-fold into macrophages, compared to CpG ODN in a TLR-9 receptor-specific manner. In addition, internalized CpG–Man conjugate successfully triggered TNF-α release in macrophages. Taken together, the CpG–Man conjugate can serve as the promising delivery systems of CpG ODN into immune cells as a candidate adjuvant.
A New Approach Towards Text Filtering (2009)

The problem of malicious contents in blogs has reached epic proportions and various efforts are underway to fight it. Blog classification using machine learning techniques is a key method towards doing it. We have devised a machine learning algorithm where features are created from individual sentences in the body of a blog by taking one word at a time. Weights are assigned to the features based on the strength of their predictive capabilities for illegitimate/legitimate determination. The predictive capabilities are estimated by the frequency of occurrence of the feature in illegitimate/legitimate collections. During classification, total illegitimate and legitimate evidence in the blog is obtained by summing up the weights of extracted features of each class and the message is classified into whichever class accumulates the greater sum. We compared the algorithm against the popular Naive Bayes algorithm and found its performance does not deteriorate in the least than that of Naive Bayes algorithm both in terms of catching blog spam and for reducing false positives.