gebhart/patrepeval huggingface dataset:
A CMOS high-speed wide-range programmable counter (2002)

A CMOS high speed wide-range programmable divide-by-N counter was designed and the performance was verified by SPICE simulations and the measurements on the fabricated chip. A new reloading scheme and the use of simplified circuits for three least significant bit flip-flops enabled the high-speed operation of the proposed counter, independently of the number of counter stages. The proposed and Chang's counters were fabricated on the same chip using a 0.6-/spl mu/m triple-metal CMOS technology. The proposed and Chang's counters with six stages were measured to work up to the clock frequencies of 1.34 GHz and 930 MHz, respectively.
ON THE CONVERGENCE OF THE MODIFIED SZASZ-MIRAKJAN OPERATOR (1994)

A necessary and sufficient condition of convergence for the modified Szasz-Mirakjan operator is estab-lished.
Metallorganische Verbindungen XXIV Organo‐Aluminium‐Fluoride (1957)

Abstract Es werden Dialkylaluminium‐fluoride R 2 AlF und deren Komplexverbindungen mit Alkalifluoriden beschrieben. Die Natriumfluorid‐Komplexverbindungen Na[AlR 2 F 2 ] zersetzen sich in der Hitze in Kryolith und Aluminiumtrialkyle. Alkylaluminiumdifluoride sind schwierig herzustellen und ähneln in ihren Eigenschaften dem Aluminiumfluorid.
Synthesen von Cholinphosphatiden, IV. <i>O</i>‐Methylierte und <i>O</i>‐acetylierte Lysolecithine (1967)

Abstract Es werden einige einfache Synthesen für racemische 2‐substituierte 1‐Acyl‐glycerin‐phosphorsäure‐(3)‐cholinester ( 1 – 4 ) sowie der entsprechenden Diglycerid‐Vorstufen ( 5 – 8 ) beschrieben.
Robust control of heterogeneous vehicular platoon with uncertain dynamics and communication delay (2016)

Platoon formation of highway vehicles has the potential to significantly enhance road safety, improve highway utility, and increase traffic efficiency. However, various uncertainties and disturbances that are present in real‐world driving conditions make the implementation of vehicular platoon a challenging problem. This study presents an H‐infinity control method for a platoon of heterogeneous vehicles with uncertain vehicle dynamics and uniform communication delay. The requirements of string stability, robustness and tracking performance are systematically measured by the H‐infinity norm, and explicitly satisfied by casting into the linear fractional transformation format. A delay‐dependent linear matrix inequality is derived to numerically solve the distributed controllers for each vehicle. The performances of the controlled platoon are theoretically analysed by using a delay‐dependent Lyapunov function which includes a linear quadratic function of states during the delay period. Simulations with a platoon of heterogeneous vehicles are conducted to demonstrate the effectiveness of the proposed method under random parameters and external disturbances.
Automatic EO/IR sensor image registration (2002)

This paper presents an automatic EO/IR sensor image registration algorithm which is based on Zheng-Chellappa's (see Proc. International Conference on Pattern Recognition, The Hague, Netherlands, p.193-7, September 1992) point feature image matching work. Several apsects of this algorithm including feature extraction, feature matching and consistency checking are discussed in detail. Experimental results using real EO/IR sensor data are presented.
Functional Significance of Factor H Binding to <i>Neisseria meningitidis</i> (2006)

Neisseria meningitidis is an important cause of septicemia and meningitis. To cause disease, the bacterium must successfully survive in the bloodstream where it has to avoid being killed by host innate immune mechanisms, particularly the complement system. A number of pathogenic microbes bind factor H (fH), the negative regulator of the alternative pathway of complement activation, to promote their survival in vivo. In this study, we show that N. meningitidis binds fH to its surface. Binding to serogroups A, B, and C N. meningitidis strains was detected by FACS and Far Western blot analysis, and occurred in the absence of other serum factors such as C3b. Unlike Neisseria gonorrhoeae, binding of fH to N. meningitidis was independent of sialic acid on the bacterium, either as a component of its LPS or its capsule. Characterization of the major fH binding partner demonstrated that it is a 33-kDa protein; examination of insertion mutants showed that porins A and B, outer membrane porins expressed by N. meningitidis, do not contribute significantly to fH binding. We examined the physiological consequences of fH bound to the bacterial surface. We found that fH retains its activity as a cofactor of factor I when bound to the bacterium and contributes to the ability of N. meningitidis to avoid complement-mediated killing in the presence of human serum. Therefore, the recruitment of fH provides another mechanism by which this important human pathogen evades host innate immunity.
Variable Speed Drives (1971)

Once it has been established by a machine designer or user that there is a necessity for driving a certain piece of machinery at a variable speed, the designer is able to select from many and varied methods of obtaining a variable speed output. The desired result may be achieved by three basic methods: (1) Mechanically. (2) Hydraulically. (3) Electrically. However, many forms of these basic methods are available, resulting in considerable difficulty in narrowing down the choice.
A Lewis Acid Catalyst Anchored on Silica Grafted with Quaternary Alkylammonium Chloride Moieties (2001)

Resistance to leaching and re-usability are characteristic of the novel heterogeneous Lewis acid catalyst that was prepared by anchoring tin(IV) chloride on silica grafted with tetraalkylammonium or pyridinium chloride groups. The catalyst displays high activity and selectivity in the synthesis of 3-methyl-3-buten-1-ol by the Prins condensation of isobutene with formaldehyde [Eq. (1)].
Polymer Infrared Proximity Sensor Array (2011)

A near-infrared proximity sensor array is achieved by integrating a polymer light-emitting diode and a polymer photodetector (PD). A green emission is converted into deep red peaked at 670 nm by the inorganic phosphor Intematix R670 with quantum efficiency of over 20%. A bandpass filter is used to select a spectral tail of phosphor luminescence with a wavelength above 700 nm. The emissive polymer is green polyfluorene. The infrared PD contains a thick film of a blend of poly(3-hexylthiophene) and (6,6)-phenyl-C61-butyric acid methyl ester up to a thickness of 8 m. Position of a moving object at a distance of 10 cm is detected in real time by the array with dynamic images displayed on the computer screen.
Digital Interface Handbook (2013)

A digital interface is the technology that allows interconnectivity between multiple pieces of equipment. In other words hardware devices can communicate with each other and accept audio and video material in a variety of forms. The Digital Interface Handbook is a thoroughly detailed manual for those who need to get to grips with digital audio and video systems. Francis Rumsey and John Watkinson bring together their combined experience to shed light on the differences between audio interfaces and show how to make devices 'talk to each' in the digital domain despite their subtle differences. They also include detailed coverage of all the regularly used digital video interfaces. New information included in this third edition: dedicated audio interfaces, audio over computer network interfaces and revised material on practical audio interfacing and synchronisation.
Reviews of Books (1899)

Reviews of Books P. T. P. T. Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume XIV, Issue LVI, October 1899, Pages 814-b–815, https://doi.org/10.1093/ehr/XIV.LVI.814-b Published: 01 October 1899
Conversion of Bis(trichloromethyl) Carbonate to Phosgene and Reactivity of Triphosgene, Diphosgene, and Phosgene with Methanol<sup>1</sup> (2000)

Triphosgene was decomposed quantitatively to phosgene by chloride ion. The reaction course was monitored by IR spectroscopy (React-IR), showing that diphosgene was an intermediate. The methanolysis of triphosgene in deuterated chloroform, monitored by proton NMR spectroscopy, gave methyl chloroformate and methyl 1,1,1-trichloromethyl carbonate in about a 1:1 ratio, as primary products. The reaction carried out in the presence of large excess of methanol (0.3 M, 30 equiv) was a pseudo-first-order process with a kobs of 1.0 × 10-4 s-1. Under the same conditions, values of kobs of 0.9 × 10-3 s-1 and 1.7 × 10-2 s-1 for the methanolysis of diphosgene and phosgene, respectively, were determined. The experimental data suggest that, under these conditions, the maximum concentration of phosgene during the methanolysis of triphosgene and diphosgene was lower than 1 × 10-5 M. Methyl 1,1,1-trichloromethyl carbonate was synthesized and characterized also by the APCI-MS technique.
Human anti-cytomegalovirus (CMV) immunoglobulins secreted by EBV-transformed B-lymphocytes cell lines. (1984)

The in vitro production of human immunoglobulins against cytomegalovirus may have clinical potentials. The attempts to produce human monoclonal antibodies by somatic cell hybridization have been unsuccessful so far. Another approach is to establish B-lymphoblastoid cell lines secreting specific antibodies. Usually such cell lines have been initiated after enrichment of antibody producing B-cells before immortalization by Epstein-Barr virus. We investigated the possibility of establishing lines secreting antibodies neutralizing human cytomegalovirus infectivity by selecting leucocyte donors who have undergone clinical disease which resulted in natural enrichment of antibody producing cells. Two cell lines were established from a patient with a severe post-transfusional CMV syndrome and one cell line from a patient who has continuously shed CMV since renal transplantation 10 years ago. The characterization of the specific immunoglobulin production of these lines will be presented.
Nonlinear Analysis of the Separate Contributions of Autonomic Nervous Systems to Heart Rate Variability Using Principal Dynamic Modes (2004)

This paper introduces a modified principal dynamic modes (PDM) method, which is able to separate the dynamics of sympathetic and parasympathetic nervous activities. The PDM is based on the principle that among all possible choices of expansion bases, there are some that require the minimum number of basis functions to achieve a given mean-square approximation of the system output. Such a minimum set of basis functions is termed PDMs of the nonlinear system. We found that the first two dominant PDMs have similar frequency characteristics for parasympathetic and sympathetic activities, as reported in the literature. These results are consistent for all nine of our healthy human subjects using our modified PDM approach. Validation of the purported separation of parasympathetic and sympathetic activities was performed by the application of the autonomic nervous system blocking drugs atropine and propranolol. With separate applications of the respective drugs, we found a significant decrease in the amplitude of the waveforms that correspond to each nervous activity. Furthermore, we observed near complete elimination of these dynamics when both drugs were given to the subjects. Comparison of our method to the conventional low-frequency/high-frequency ratio shows that our proposed approach provides more accurate assessment of the autonomic nervous balance. Our nonlinear PDM approach allows a clear separation of the two autonomic nervous activities, the lack of which has been the main reason why heart rate variability analysis has not had wide clinical acceptance.
Single Phase PV Inverter Applying a Dual Boost Technology (2015)

In this paper, a single-phase PV inverter applying a dual boost converter circuit inverter is proposed for photovoltaic (PV) generation system and PV grid connected system. This system is designed to improve integration of a Single phase inverter with Photovoltaic panel. The DC 24V is converted into to 86V DC and then 86V DC to 312V DC. The 312 V DC is then successfully inverted to AC 220V. Hence solar energy is powerfully converted into electrical energy for fulfilling the necessities of the home load, or to link with the grid. Matlab Simulation software was used for simulation of the circuit and outcome are presented in this paper.
LES ORIGINES DE LA CONSTRUCTION SOUCIEUSE DES RESSOURCES ET DE L’ÉNERGIE (2008)

«S’agit-il de construire une ville? La premiere chose a faire est de choisir un endroit sain. Il doit etre eleve, a l’abri des brouillards et du givre, situe sous la douce temperature d’un ciel pur, sans avoir a souffrir ni d’une trop grande chaleur ni d’un trop grand froid. […]» (1) Dans son celebre traite De architectura, Vitruve pose une des premieres pierres de la tradition de l’architecture et de l’urbanisme. Il s’inspire pour ce faire de ce qu’ont laisse les Grecs dans ces domaines. Il explique en detail l’influence du soleil sur les differentes fonctions urbaines. Les Grecs et les Romains connaissaient en effet depuis longtemps l’importance d’une bonne orientation pour l’utilisation d’un bâtiment.
Déterminants du militantisme et projet syndical des ouvriers et des techniciens (1965)

Les responsables d'organisations syndicales ont été souvent étudiés soit sous un angle purement psychologique, en termes de personnalité, de motivations, à partir de leurs caractéristiques individuelles, soit dans une perspective psycho-sociologique , en termes de statut et de rôle dans l'organisation, en opposant parfois la «base» et le «sommet» du syndicat. Sans nier l'intérêt de telles approches, le militantisme syndical, analysé ici par rapport à la mobilité sociale et professionnelle, est interprété en termes de projet, en référence à une structure socio-professionnelle relativement «fermée» dans le cas des ouvriers, et relativement «ouverte» dans celui des techniciens. La signification du projet syndical est recherchée à partir du désir d' indépendance, de la représentation du travail, et de la participation socio-politique. Les données présentées permettent une comparaison entre les militants, les adhérents, et les sympathisants d'une même fédération syndicale.
Butyrate-induced apoptotic cascade in colonic carcinoma cells: modulation of the beta-catenin-Tcf pathway and concordance with effects of sulindac and trichostatin A but not curcumin. (1999)

Short-chain fatty acids play a critical role in colonic homeostasis because they stimulate pathways of growth arrest, differentiation, and apoptosis. These effects have been well characterized in colonic cell lines in vitro. We investigated the role of beta-catenin-Tcf signaling in these responses to butyrate and other well-characterized inducers of apoptosis of colonic epithelial cells. Unlike wild-type APC, which down-regulates Tcf activity, butyrate, as well as sulindac and trichostatin A, all inducers of G0-G1 cell cycle arrest and apoptosis in the SW620 colonic carcinoma cell line, up-regulate Tcf activity. In contrast, structural analogues of butyrate that do not induce cell cycle arrest or apoptosis and curcumin, which stimulates G2-M arrest without inducing apoptosis, do not alter Tcf activity. Similar to the cell cycle arrest and apoptotic cascade induced by butyrate, the up-regulation of Tcf activity is dependent upon the presence of a mitochondrial membrane potential, unlike the APC-induced down-regulation, which is insensitive to collapse of the mitochondrial membrane potential. Moreover, the butyrate-induced increase in Tcf activity, which is reflected in an increase in beta-catenin-Tcf complex formation, is independent of the down-regulation caused by expression of wild-type APC. Thus, butyrate and wild-type APC have different and independent effects on beta-catenin-Tcf signaling. These data are consistent with other reports that suggest that the absence of wild-type APC, associated with the up-regulation of this signaling pathway, is linked to the probability of a colonic epithelial cell entering an apoptotic cascade.
Local planar gradients with order‐of‐magnitude strength and speed advantage (2007)

A three-axis uniplanar gradient coil was designed and built to provide order-of-magnitude increases in gradient strength of up to 500 mT/m on the x- and y-axes, and 1000 mT/m for the z-axis at 640 A input over a limited FOV ( approximately 16 cm) for superficial regions, compared to conventional gradient coils, with significant gradient strengths extending deeper into the body. The gradient set is practically accommodated in the bore of a conventional whole-body, cylindrical-geometry MRI scanner, and operated using standard gradient supplies. The design was optimized for gradient linearity over a restricted volume while accounting for the practical problems of torque and heating. Tests at 320 A demonstrated up to 420-mT/m gradients near the surface at efficiencies of up to 1.4 mT/m/A. A new true 2D gradient-nonlinearity correction algorithm was developed to rectify gradient nonlinearities and considerably expand the imageable volumes. The gradient system and correction algorithm were implemented in a standard 1.5 T scanner and demonstrated by high-resolution imaging of phantoms and humans.
Westinghouse Advanced Particle Filter System (1994)

Integrated Gasification Combined Cycles (IGCC) and Pressurized Fluidized Bed Combustion (PFBC) are being developed and demonstrated for commercial, power generation application. Hot gas particulate filters are key components for the successful implementation of IGCC and PFBC in power generation gas turbine cycles. The objective of this work is to develop and qualify through analysis and testing a practical hot gas ceramic barrier filter system that meets the performance and operational requirements of PFBC and IGCC systems. This paper reports on the development and status of testing of the Westinghouse Advanced Hot Gas Particle Filter (W-APF) including: W-APF integrated operation with the American Electric Power, 70 MW PFBC clean coal facility--approximately 6000 test hours completed; approximately 2500 hours of testing at the Hans Ahlstrom 10 MW PCFB facility located in Karhula, Finland; over 700 hours of operation at the Foster Wheeler 2 MW 2nd generation PFBC facility located in Livingston, New Jersey; status of Westinghouse HGF supply for the DOE Southern Company Services Power System Development Facility (PSDF) located in Wilsonville, Alabama; the status of the Westinghouse development and testing of HGF`s for Biomass Power Generation; and the status of the design and supply of the HGF unit for the 95 MW Pinon Pine IGCC Clean Coal Demonstration.
The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls (2016)

Patients with PSC exhibited a gut microbial signature distinct from both HC and UC without liver disease, but similar in PSC with and without IBD. The <i>Veillonella</i> genus, which is also associated with other chronic inflammatory and fibrotic conditions, was enriched in PSC.
Wilm's Tumor 1 Protein Confers TRAIL Resistance in Myeloid Leukemia Cells Through Bcl-Xl (2011)

Abstract Abstract 2557 INTRODUCTION: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an attractive therapeutic agent because of its selective potential to induce apoptosis in variety of tumors but not in normal cells. However, many cancers including myeloid leukemias exhibit resistance to TRAIL and the underlying mechanisms are not fully understood. Wilms' tumor 1 (WT1) protein is an aberrantly overexpressed protein that is associated with leukemia blast survival, chemoresistance and shortened disease-free survival in acute myeloid leukemia (AML). Here, we report a previously unknown protective role of WT1 against TRAIL-induced apoptosis in leukemia cells. METHODS: Various myeloid leukemia cell lines with variable WT1 expression levels were tested for TRAIL sensitivity. The effect of pharmacological or short hairpin RNA (shRNA)-mediated inhibition of WT1 on TRAIL-induced apoptosis was evaluated by AnnexinV/PI staining method. The mRNA levels of WT1 and Bcl-xL were measured by reverse transcription-PCR (RT-PCR) and the expression of apoptosis regulators were analyzed by western blotting. RESULTS: We observed a strong correlation between higher levels of WT1 and increased TRAIL resistance in myeloid leukemia cell lines. WT1 downregulation by shRNA significantly sensitized leukemia cells to TRAIL-induced apoptosis and importantly, ectopic expression of shRNA resistant WT1 (WT1SR) in WT1-knockdown cells restored the TRAIL resistance. WT1 influences apoptosis through transcriptional regulation of Bcl-2 family members such as Bcl-2 and Bak. We found for the first time, a positive correlation between WT1 and Bcl-xL expression in leukemia cell lines and primary AML samples. Furthermore, using chromatin immunoprecipitation (ChIP) analysis, we show that Bcl-xL is a bonafide WT1-target gene as WT1 transctivates Bcl-xL by binding to its promoter. We have (Bansal et al., Blood 2010) recently shown that the expression and oncogenic functions of WT1 could be abrogated by heat shock protein 90 (Hsp90) inhibitors in myeloid leukemia cells. In order to establish whether Hsp90- mediated regulation of WT1 has any functional significance in TRAIL-resistance we treated leukemia cell with the Hsp90 inhibitor, 17-allylamino-17-demethoxygeldanamycin (17-AAG). The results confirm that Hsp90 inhibition was able to overcome TRAIL resistance, by reducing levels of WT1 and Bcl-xL and by increasing the levels of the proapoptotic protein Bak. Taken together, our results reveal that increased expression of Bcl-xL, along with low Bak, confer WT1-mediated TRAIL resistance. CONCLUSION: Our data indicate that TRAIL resistance in myeloid leukemia cells is mediated by overexpression of the panleukemic marker WT1 and this can be overcome by either silencing WT1 or by pharmacologic inhibitors such as 17-AAG. of Hsp90. Our study highlights the potential therapeutic benefit of the combining TRAIL and Hsp90 inhibitors for the treatment of myeloid leukemias. Disclosures: No relevant conflicts of interest to declare.