gebhart/patrepeval huggingface dataset:
Synthesis and biological activity of some methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and biological activity of some methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonistsCarlo Melchiorre, Maria L. Bolognesi, Alberto Chiarini, Anna Minarini, and Santi SpampinatoCite this: J. Med. Chem. 1993, 36, 23, 3734–3737Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/jm00075a032https://doi.org/10.1021/jm00075a032research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Limits of high-order perturbation theory in time-domain optical mammography (2006)

Higher order corrections to the Born approximation in perturbation theory are derived in order to improve its performance with the experiments in slablike geometry. A general expression of the nth order correction to absorption is developed. The cross talking between absorption and scattering is given. The convergence for higher orders of perturbation analysis for absorbing inclusions was studied. Second order absorption and scattering contributions to the transmitted flux are discussed by analyzing the data from forward simulations. The validity of the results is proven in the experiments with phantoms simulating breast tumors. The significant improvement for the fitted values of the absorption is observed. The alternative application of developed formalism as the first order theory to treat the multiple inclusions is suggested.
Neurone-specific enolase and Sangtec 100 assays during cardiac surgery: part I - the effects of heparin, protamine and propofol (1997)

Neurone-specific enolase (NSE) and Sangtec 100 (S-100) (Sangtec Medical, Sweden) assays are designed for clotted samples, but when studying cerebral damage following cardiac surgery, perioperative samples will contain heparin and/or protamine. The lipid emulsion propofol is also frequently used during cardiac surgery and could affect the assays. We, therefore, studied the effects of heparin, protamine and propofol on the accuracy of NSE and S-100 assays in five healthy patients. Blood samples were taken and divided into four groups: normal saline was added to group A; heparin to group B; heparin followed by protamine to group C; and propofol to group D. NSE and S-100 concentrations were measured for all samples. Neither heparin, protamine nor propofol affected the accuracy of S-100 and NSE assays; therefore, samples can be taken throughout operations involving cardiopulmonary bypass without influencing the results.
The anti-proliferative and differentiation-inducing effects of vitamin D analogs are not determined by the binding affinity for the vitamin D receptor alone. (1996)

Calcipotriol, a synthetic analog of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25[OH]2D3), is used in the treatment of psoriasis. In this investigation, the biological profile of calcipotriol and of two new vitamin D analogs, EB 1213 and GS 1500, has been studied and compared with the profile of 1 alpha,25(OH)2D3. Despite the fact that the affinity for the intracellular vitamin D receptor of the three analogs is comparable (EB 1213) or lower (GS 1500, calcipotriol) than that of 1 alpha,25(OH)2D3, they were all found to be more potent in inhibiting human skin cell proliferation in vitro. The anti-proliferative effect was accompanied by a change in the cytokeratin pattern of the skin cells, indicating a differentiation-inducing effect of the compounds similar to that of 1 alpha,25(OH)2D3. Further investigations including ligand-induced vitamin D receptor transcription studies in chloramphenicol acetyl transferase assays showed that EB 1213 and GS 1500 were more efficient than 1 alpha,25(OH)2D3 in inducing vitamin D receptor transcription. This strongly indicates that not only the binding affinity for the receptor, but more importantly, the ability of the compounds to induce vitamin D receptor transcription, is a determinant of the biological activity of the compounds.
Unrepeated 20-Gbit/s QPSK transmission over standard single-mode fiber using homodyne detection and digital signal processing for dispersion compensation (2006)

We demonstrate unrepeated transmission of 20-Gbit/s QPSK signals over a 200-km-long standard single-mode fiber without any optical dispersion compensator. Digital signal processing after homodyne detection enables demodulation and dispersion compensation of the transmitted QPSK signal.
Application of medical thoracoscopy in diagnosis of sarcoidosis‐related pleural effusion (2014)

Pleural effusion caused by sarcoidosis is unusual. Medical thoracoscopy could help clinicians detect associated pleural disease, yet studies on thoracoscopic observations in sarcoidosis pleural involvement are rare. In this article, we report the utility of medical thoracoscopy in diagnosing sarcoid-related pleural disease for three patients. Pleural nodularity was common with solitary and multiple nodules evident; biopsies confirmed the presence of diagnostic noncaseating granulomas.
Flavor Chemistry and Technology (2005)

A much-anticipated revision of a benchmark resource, written by a renowned author, professor, and researcher in food flavors, Flavor Chemistry and Technology, Second Edition provides the latest information and newest research developments that have taken place in the field over the past 20 years. New or expanded coverage includes:Flavor and the Inf
Conformity in heart rate variability under online game without conversations (2009)

This paper describes the coaction-indexes based on physiological experiments in online-works such as tele-working or online-gaming in the Net. We think the important factor on online works is sharing strategies and situations. If the strategies are shared in the work, it is considered that self-regard operations decreases, and/or the conformities are seen in the physiological response by the situation acknowledgment. We experimented in the online action game. Two players had to be limited the conversation, and to acknowledge the strategy only by information on the screen. We measured the frequency of player's switch button as a behavioral indicator. Moreover, the heartbeat fluctuation was measured as a physiology index. The frequency of the button has decreased by the progress of the game from the experiment. Moreover, it has been understood that consideration is shared from the conformity of the heartbeat fluctuation by the same scene.
Dynamic Changes in ANGUSTIFOLIA3 Complex Composition Reveal a Growth Regulatory Mechanism in the Maize Leaf (2015)

Most molecular processes during plant development occur with a particular spatio-temporal specificity. Thus far, it has remained technically challenging to capture dynamic protein-protein interactions within a growing organ, where the interplay between cell division and cell expansion is instrumental. Here, we combined high-resolution sampling of the growing maize (Zea mays) leaf with tandem affinity purification followed by mass spectrometry. Our results indicate that the growthregulating SWI/SNF chromatin remodeling complex associated with ANGUSTIFOLIA3 (AN3) was conserved within growing organs and between dicots and monocots. Moreover, we were able to demonstrate the dynamics of the AN3-interacting proteins within the growing leaf, since copurified GROWTH-REGULATING FACTORs (GRFs) varied throughout the growing leaf. Indeed, GRF1, GRF6, GRF7, GRF12, GRF15, and GRF17 were significantly enriched in the division zone of the growing leaf, while GRF4 and GRF10 levels were comparable between division zone and expansion zone in the growing leaf. These dynamics were also reflected at the mRNA and protein levels, indicating tight developmental regulation of the AN3-associated chromatin remodeling complex. In addition, the phenotypes of maize plants overexpressing miRNA396aresistant GRF1 support a model proposing that distinct associations of the chromatin remodeling complex with specific GRFs tightly regulate the transition between cell division and cell expansion. Together, our data demonstrate that advancing from static to dynamic protein-protein interaction analysis in a growing organ adds insights in how developmental switches are regulated.
P-selectin and Platelet-Derived Microparticles Associated with Monocyte Activation Markers in Patients with Pulmonary Embolism (2003)

Platelet activation markers (platelet-derived microparticles and P-selectin on activated platelets), chemokines (monocyte chemotactic peptide and regulated on activation normally T-cell expressed and secreted), and soluble markers (sP-selectin, sE-selectin, sVCAM-1, and sCD14) were measured and compared in patients with pulmonary embolism (PE). These substances are thought to participate in the pathogenesis of PE. Levels of all of the platelet activation markers, chemokines, and soluble markers were higher in the patients with PE than in normal controls. Levels of platelet activation markers were also significantly increased postoperatively after total knee arthroplasty. Anti-platelet therapy significantly inhibited the elevation of platelet activation markers after total knee arthroplasty. These findings suggest that antiplatelet therapy may be useful for PE-related interaction of platelets, leukocytes, and endothelial cells.
SU-APSD: Static IEEE 802.11e Unscheduled Automatic Power Save Delivery (2006)

The integration of the wireless LAN technology in mobile devices as cellular phones or PDAs has become a user need due to its popularity in providing high speed wireless Internet access at a low cost. Such devices though should meet users' expectations with regard to QoS, e.g., guarantee a reasonable voice quality when VoIP is used, and power saving efficiency, e.g., standby and calling times should be similar to the ones of cellular phones. IEEE 802.11e defines QoS and power saving enhancements that should allow the wireless LAN technology address users' wishes in such specific devices. However, there are several questions that need to be answered in order to assess whether the additional complexity introduced by these mechanisms would be justified by a relevant performance improvement. With our work we contribute to answer these questions by i) identifying the likely 802.11e functionality to be implemented in mobile devices in the short-term (EDCA+U-APSD) ii) proposing a specific implementation of the U-APSD mechanism (SU-APSD) and iii) evaluating the performance improvement obtained as compared to 802.11 standard power save mode.
Invited review GPCR structural characterization: Using fragments as building blocks to determine a complete structure (2014)

The structural characterization of G protein-coupled receptors has surged since the development of methodologies to facilitate the crystallization of these highly helical, seven transmembrane, integral membrane receptors. In the past seven years, eighteen GPCR structures were determined by X-ray crystallography. The crystal structures represent a static picture of these conformationally flexible signal transducers. Analyses that probe their dynamics and conformational changes require other techniques, in particular solution state nuclear magnetic resonance studies. Such investigations are challenged by the size of GPCRs, their α-helical structure, which limits resonance dispersion, their tendencies to aggregate in micellar preparations and their conformational heterogeneity. For many years, groups have been studying GPCR fragments as a means to overcome some of these difficulties. The results of these fragment analyses are presented here. Review of the literature reveals that much of the original work depended on circular dichroism, infra-red spectroscopy and fluorescence approaches. High resolution structures obtained by NMR are compared, where applicable, to the available crystal structures. In most cases, the work done on fragments by biophysical analysis is validated by these comparisons. Our perspective on the field of GPCR fragment analysis is presented together with the future goals that must be considered if work with fragments is continued.
Chemical vapor deposition of fluoroalkylsilane monolayer films for adhesion control in microelectromechanical systems (2000)

We have developed a new process for applying a hydrophobic, low adhesion energy coating to microelectromechanical (MEMS) devices. Monolayer films are synthesized from tridecafluoro-1,1,2,2- tetrahydrooctyltrichlorosilane (FOTS) and water vapor in a low-pressure chemical vapor deposition process at room temperature. Film thickness is self-limiting by virtue of the inability of precursors to stick to the fluorocarbon surface of the film once it has formed. We have measured film densities of ∼3 molecules nm2 and film thickness of ∼1 nm. Films are hydrophobic, with a water contact angle &gt;110°. We have also incorporated an in situ downstream microwave plasma cleaning process, which provides a clean, reproducible oxide surface prior to film deposition. Adhesion tests on coated and uncoated MEMS test structures demonstrate superior performance of the FOTS coatings. Cleaned, uncoated cantilever beam structures exhibit high adhesion energies in a high humidity environment. An adhesion energy of 100 mJ m−2 is observed after exposure to &gt;90% relative humidity. Fluoroalkylsilane coated beams exhibit negligible adhesion at low humidity and ⩽20 μJ m−2 adhesion energy at &gt;90% relative humidity. No obvious film degradation was observed for films exposed to &gt;90% relative humidity at room temperature for ∼24 h.
A simplified technique for constructing a tube feeding gastrostomy. (1981)

A technique has been developed to establish a tube feeding gastrostomy without the need for laparotomy or general anesthesia. To date, it has been used in 53 patients with excellent results. This technique should prove to be the preferred method in the performance of tube feeding gastrostomy.
Monolithic oxide-confined multiple-wavelength vertical-cavity surface-emitting laser arrays with a 57-nm wavelength grading range using an oxidized upper Bragg mirror (2000)

Monolithic, oxide-confined, multiple-wavelength vertical-cavity surface-emitting laser arrays with a very large periodic, wavelength grading span of 57 nm (from 968 to 1025 nm) have been achieved under room temperature, continuous-wave operation, with threshold currents of 4.5 mA/spl plusmn/1.5 mA. Almost linear wavelength grading is achieved by organometallic vapor phase epitaxial growth on a patterned substrate. An extended wavelength range is achieved by minimizing the optical loss dispersion by scaling the growth rate of all the epilayers and using a selectively-oxidized upper DBR mirror with a flattened optical reflectance spectrum, plus the higher differential optical gain provided by compressively-strained In/sub 0.2/Ga/sub 0.8/As-GaAs quantum wells.
Catalytic Disproportionation of Formic Acid to Generate Methanol (2013)

The homogeneously catalyzed disproportionation of formic acid to methanol, water, and carbon dioxide is accomplished by only 10 ppm of a readily accessible iridium catalyst, [Cp*Ir(bpy)(H2O)]2+ (Cp*=pentamethylcyclopentadienyl, bpy=2,2′-bipyridine). Methanol is produced under mild, aqueous conditions, without the use of any organic solvents or hydrogen gas. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Comparative Study of Some Isolated Mammalian Smooth Muscle Effectors of Penile Erection (1977)

Spontaneous rhythmic activity, responses to drugs and effects of field stimulation of nerves of the retractor penis (rp) and/or corpus cavernosum urethrae (ccu) of macaque, rabbit, guinea-pig, rat, dog, cat, horse, boar, elk, bull, ram and goat, as well as of the penile artery (pa) of bull were studied. A basic property of all these muscles was automaticity. Their responses to 5-hydroxytryptamine, histamine, adenosine triphosphate, prostaglandins E1, E2, AND F2alpha, oxytocin, vasopressin, substance P, bradykinin and angiotensin exhibited considerable species variations. Their excitatory innervation seems to be adrenergic. They also have an inhibitory innervation. In spite of comprehensive pharmacological analysis the inhibitory mediator remains obscure. The frequency--response relationship to inhibitory nerve stimulation was characterized by a rapidly achieved maximum at low frequencies, indicating high efficiency of the neuroeffector unit.
Accurate multi-view reconstruction using robust binocular stereo and surface meshing (2008)

This paper presents a new algorithm for multi-view reconstruction that demonstrates both accuracy and efficiency. Our method is based on robust binocular stereo matching, followed by adaptive point-based filtering of the merged point clouds, and efficient, high-quality mesh generation. All aspects of our method are designed to be highly scalable with the number of views. Our technique produces the most accurate results among current algorithms for a sparse number of viewpoints according to the Middlebury datasets. Additionally, we prove to be the most efficient method among non-GPU algorithms for the same datasets. Finally, our scaled-window matching technique also excels at reconstructing deformable objects with high-curvature surfaces, which we demonstrate with a number of examples.
Simultaneous Sourcing Without Compromise (2008)

The use of high-efficiency simultaneous sourcing methods results in a signal-to-noise<br>compromise. Noise arises because multiple seismograms need to be recovered or separated<br>from a smaller number of vibroseis field records compared to methods, such as HFVS (High<br>Fidelity Vibratory Seismic), in which there are as many sweeps as there are vibrators. We<br>show that iterative methods can improve the separation and remove noise for seismograms<br>recorded with multiple vibrators operating simultaneously with a single sweep. The iterative<br>methods start with an initial separation. Then, updated seismograms are produced by<br>adjusting them to match the survey data and to satisfy characteristics of noise-free<br>seismograms. The match to survey data involves reconvolving parts of the initial<br>seismograms with an estimate of the vibrator signatures and stacking. The method is<br>especially effective at removing the noise at the bottom of records for Continuous-HFVS SM<br>(Krohn and Johnson, 2005). With these iterative methods, the full efficiency of simultaneous<br>sourcing can be obtained without a noise compromise.
The Virucidal Properties of Peracetic Acid (1960)

Journal Article The Virucidal Properties of Peracetic Acid Get access Louise Briefman Kline, M.A., Louise Briefman Kline, M.A. Lilly Research Laboratories, Indianapolis, Indiana Search for other works by this author on: Oxford Academic Google Scholar Robert N. Hull, Ph.D. Robert N. Hull, Ph.D. Lilly Research Laboratories, Indianapolis, Indiana Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 33, Issue 1, 1 January 1960, Pages 30–33, https://doi.org/10.1093/ajcp/33.1.30 Published: 01 January 1960 Article history Received: 08 August 1959 Revision received: 26 August 1959 Accepted: 02 October 1959 Published: 01 January 1960
Enzymatic Esterification of Fatty Acid Mixtures from Milk Fat and Anhydrous Milk Fat with Canola Oil in Supercritical Carbon Dioxide (1992)

Abstract The ester ethyl oleate was synthesized from oleic acid and ethanol by using the lipase, Candida cylindracea , immobilized on Celite 545 and in supercritical carbon dioxide (SC‐CO 2 ) as the solvent. The enzymatic esterification reaction is much faster in SC‐CO 2 than in organic solvents. This technique was then applied to the hydrolysis products of milk fat to determine the feasibility of using it as a process to enhance flavor. Gas chromatographic (GC) analysis of the ethyl esters showed that short‐chain fatty acids (C 4 ‐C 8 ) esterify more completely than long‐chain fatty acids (C 16 ‐C 18 ). The technique was then applied to interesterify a mixture of triglycerides from canola oil (CNO) and anhydrous milk fat (AMF). The starting mixture contained predominantly C 52 ‐C 56 triglycerides from the CNO and C 32 ‐C 38 triglycerides from the AMF. The product exhibited predominantly the C 42 ‐C 50 and C 54 triglycerides.
IFN‐γ activation of mesenchymal stem cells for treatment and prevention of graft <i>versus</i> host disease (2008)

Graft versus host disease (GVHD), mediated by donor T cells, is a significant source of morbidity and mortality following allogeneic stem cell transplantation. Mesenchymal stem cells (MSC) can successfully treat ongoing graft versus host disease, presumably due to their ability to suppress donor T cell proliferation. Little is known about the potential of MSC to prevent GVHD. Here we show that bone marrow-isolated MSC can suppress the development of GVHD if given after donor T cell recognition of antigen. IFN-gamma was required to initiate MSC efficacy. Recipients of IFN-gamma(-/-) T cells did not respond to MSC treatment and succumbed to GVHD. MSC, pre-treated with IFN-gamma, became immediately active and could suppress GVHD more efficiently than a fivefold-greater number of MSC that were not activated. When given at the time of bone marrow transplantation, activated MSC could prevent GVHD mortality (100% survival, p=0.006). MSC activation was dependent on the magnitude of IFN-gamma exposure, with increased IFN-gamma exposure leading to increased MSC suppression of GVHD. Activated MSC present a new strategy for preventing GVHD using fewer MSC.