gebhart/patrepeval huggingface dataset:
Repeated adenoviral administration into the biliary tract can induce repeated expression of the original gene construct in rat livers without immunosuppressive strategies (2004)

These results suggest that adenovirus mediated gene transfer into the liver may be repeatable without immunosuppressive strategies in clinical settings by means of endoscopic retrograde cholangiography.
Where's Waldo?: Geolocation, Mobile Apps, and Privacy (2013)

The effect of a low-monoamine diet on the 24-h urinary excretion of unconjugated catecholamines and some of their metabolites was investigated. Total (unconjugated and conjugated) 3-methoxy-4-hydroxy-phenylglycol excretion was 15% to 20% lower under the low-monoamine diet, both when calculated per 24 h and per creatinine excretion. No effect on the concentrations of unconjugated urinary catecholamines, unconjugated vanillylmandelic acid, or total normetanephrine was observed. It is concluded that, for diagnosis of neural crest tumors, no dietary restrictions are necessary, provided analytical methods such as presented are used. When 24-h urines are analysed for MHPG, however, as in psychiatric studies, dietary effects must be taken into account, especially when small differences in excretion are expected.
Reinforcing Fault Ride Through Capability of Grid Forming Voltage Source Converters Using an Enhanced Voltage Control Scheme (2018)

Medium power distributed energy resources (DERs) are commonly connected to medium voltage distribution systems via voltage source converters (VSCs). Several guidelines and standards have been developed to establish the needed criteria and requirements for DERs interconnections. In this respect, it is preferred to reinforce the VSC fault ride through (FRT) capability, which considerably minimizes the DG outage period and reconnection time and results in a resilient system against short circuits. Considering the significant number of asymmetrical faults in distribution systems, the VSC response in such conditions must be investigated, and consequently, its FRT capability must be reinforced. In this paper, first, a comprehensive review on the existing FRT methods has been presented and discussed. Accordingly, an adaptive virtual impedance-based voltage reference generation method is proposed, which enhances the VSC behavior under short circuits and increases the VSC FRT capability. Also, a fast sinusoidal current reference limiter is proposed to improve the performance. To evaluate the performance of the proposed scheme, state-space analysis is presented, and a complete set of simulations is performed in PSCAD/EMTDC environment. Also, a comparison with the conventional method is presented.
Design of a coaxially fed circularly polarized rectangular microstrip antenna using a genetic algorithm (2000)

A new application of a genetic algorithm (GA) for the design of a coaxially fed circularly polarized rectangular microstrip antenna is presented. The GA shows excellent results for the design of microstrip antennas that have a very complicated objective function, including the input impedance, the effective loss tangent, and the axial ratio. The objective function is derived from the cavity model, and we optimize the size and the feeding point of the antenna using the GA. The experimental results show good agreement with the simulated results. © 2000 John Wiley & Sons, Inc. Microwave Opt Technol Lett 26: 288–291, 2000.
Measurement of semiconductor laser amplifier noise figure in coherent optical transmission system (1989)

We report the first detailed investigation of the effect of semiconductor laser amplifier noise figure on the sensitivity of a heterodyne receiver. Independent measurement of the amplifier spontaneous noise spectral density confirms that local oscillator-spontaneous emission beat noise accounts for all of the observed penalty.
Directivity characteristics of adaptive microphone-array for noise reduction(AMNOR). (1991)

AMNOR is a new type of noise-reduction microphone system which uses a microphone arrayand digital signal processing. In this paper, the theory of AMNOR is described in the frequency domain, and its directivity characteristics are studied. Then, it is shown that, under some simple noise conditions, AMNOR forms the same directivity patterns as those formed by conventional directional microphones.
The Wavelength Dependence of the Yule-Nielsen Factor (1999)

A common problem in the printing industry today is optical dot gain. Optical dot gain is popularly thought to be caused by light scatter in paper 1. Another name for the scattering of light in a paper substrate is the Yule - Nielsen effect. The Yule-Nielsen effect is described in the following equation: R(1/n) = Fo Ri (1/n) + ( 1 - Fo) Rp (1/n) ( 1 ) This research involves studying the n factor of this equation. This factor is an index of the amount of optical dot gain and is highly correlated with the scattering coefficient of the paper. The n factor is already known to be wavelength dependent. The purpose of my research is to find out what causes n to be wavelength dependent. The factors considered were the color of ink, the opacity of the ink, the halftone dot pattern, and the degree of penetration into the paper. After completing my research I found that the relationship between n and wavelength was very similar to the absorbance spectra of
A decomposition method with minimum communication amount for parallelization of multi-dimensional FFTs (2013)

The fast Fourier transform (FFT) is undoubtedly an essential primitive that has been applied in various fields of science and engineering. In this paper, we present a decomposition method for parallelization of multi-dimensional FFTs with smallest communication amount for all ranges of the number of processes compared to previously proposed methods. This is achieved by two distinguishing features: adaptive decomposition and transpose order awareness. In the proposed method, the FFT data are decomposed based on a row-wise basis that maps the multi-dimensional data into one-dimensional data, and translates the corresponding coordinates from multi-dimensions into one-dimension so that the resultant one-dimensional data can be divided and allocated equally to the processes. As a result, differently from previous works that have the dimensions of decomposition pre-defined, our method can adaptively decompose the FFT data on the lowest possible dimensions depending on the number of processes. In addition, this row-wise decomposition provides plenty of alternatives in data transpose, and different transpose order results in different amount of communication. We identify the best transpose orders with smallest communication amounts for the 3-D, 4-D, and 5-D FFTs by analyzing all possible cases. Given both communication efficiency and scalability, our method is promising in development of highly efficient parallel packages for the FFT.
2019 AANS Annual Scientific Meeting (2019)

Introduction: Surgical services that work in open admission units often encompass various difficulties with managing their patients related to daily work flow in comparison with traditional medical services. A Neurosurgery Nursing Communication Tool (NNCT) was adapted to the pediatric neurosurgery (NSGY) population to improve team communication and understanding of patient care. There is limited research on rounding tools amongst the multi-disciplinary care team especially NSGY with nurses (RNs). Methods: This is a prospective cohort study utilizing a pre/post-implementation surveys with RNs on the pediatric unit was distributed to assess perceptions of baseline team communication. Each NNCT was assessed for various data components.
Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2 (1997)

TNF-induced activation of the transcription factor NF-kappaB and the c-jun N-terminal kinase (JNK/SAPK) requires TNF receptor-associated factor 2 (TRAF2). The NF-kappaB-inducing kinase (NIK) associates with TRAF2 and mediates TNF activation of NF-kappaB. Herein we show that NIK interacts with additional members of the TRAF family and that this interaction requires the conserved "WKI" motif within the TRAF domain. We also investigated the role of NIK in JNK activation by TNF. Whereas overexpression of NIK potently induced NF-kappaB activation, it failed to stimulate JNK activation. A kinase-inactive mutant of NIK was a dominant negative inhibitor of NF-kappaB activation but did not suppress TNF- or TRAF2-induced JNK activation. Thus, TRAF2 is the bifurcation point of two kinase cascades leading to activation of NF-kappaB and JNK, respectively.
Synthesis of 2′‐Amino‐2′‐deoxyuridine Modified by 1,8‐Naphthalimide (2006)

Abstract A simple and efficient synthetic route of 2′‐amino‐2′‐deoxyuridine was studied. 2′‐Amino‐2′‐deoxyuridine was incorporated into 1,8‐naphthalimides in the 2′‐position of 2′‐sugar via linking arms of different lengths. A convenient method for the synthesis of the conjugates was adopted.
A simple single-switch single-stage AC/DC converter with fast output voltage regulation (2002)

In this paper, a simple single-stage AC/DC converter based on the flyback topology is presented. With a single switch, a fast-regulated output voltage is achieved and, although the line current is not sinusoidal, the converter complies with the Standard IEC 1000-3-2 about low frequency harmonies for a medium power range (50-500 W). The major advantages of this converter are the size and the efficiency. Design guidelines, analysis of the line current, and extensions to other topologies are analyzed. Experimental results are included in the paper.
Don’t Mono-crop the Movement (2014)

Over the past generation, advocates for healthier food and agriculture have drawn on the farm-to-fork trope to define spatial arrangements in the foodshed. Consider farmers' markets, food hubs, community supported agriculture (CSA), co-ops, rooftop, community, and schoolyard gardens, 100-Mile Diets, and urban farms: the architecture of reform is endless, but every part seeks to reduce the distance between food producers (farms) and consumers (forks). For all the intuitive appeal of the farm-to-fork trope, however, there are other ways to think about the local food movement's spatial configurations that could be more inclusive, multidimensional, and politically potent. This article argues that instead of a distance versus proximity orientation, good-food advocates might envision a kind of cultural ecology of various efforts toward healthier food and agriculture. This perspective shows the various organizational efforts of a region interacting like species in a healthy ecosystem. Where farmers' markets might be gentrified, for example, community gardens and urban farms might not; where urban farms might be labor intensive, food hubs might not and could offer healthier food in urban spaces; where food hubs might not be convenient enough, virtual marketplaces might. The downsides of one part are carried by the advantages of another; the limitations of the first are helped by the strengths of the next. What matters here are not just the particular individual innovations—farmers' markets, CSAs, food hubs, etc.—but the ways in which they overlap to build an interdependent whole. No longer one-dimensional, this cultural ecology adds political and organizational integrity to the physical integrity of food.
Fibroblast growth factor 23 (FGF23) gene polymorphism in children with Kawasaki syndrome (KS) and susceptibility to cardiac abnormalities (2013)

The prevalent segregation of the c.212-37insC polymorphism in children with CaA advocates a possible functional FGF23 role in the predisposition to higher serum levels of FGF23 and potential occurrence of any coronary artery abnormalities in KS.
Autoría en la Revista d e Otorrinolaringología y Cirugía de Cabeza y Cuello: Análisis de tres décadas (2002)

A significant increase in the number of authors per manuscript was observed in this review.
Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro (2009)

The anti-diabetic drug metformin reduces human cancer incidence and improves the survival of cancer patients, including those with breast cancer. We studied the activity of metformin against diverse molecular subtypes of breast cancer cell lines in vitro. Metformin showed biological activity against all estrogen receptor (ER) positive and negative, erbB2 normal and abnormal breast cancer cell lines tested. It inhibited cellular proliferation, reduced colony formation and caused partial cell cycle arrest at the G(1) checkpoint. Metformin did not induce apoptosis (as measured by DNA fragmentation and PARP cleavage) in luminal A, B or erbB2 subtype breast cancer cell lines. At the molecular level, metformin treatment was associated with a reduction of cyclin D1 and E2F1 expression with no changes in p27(kip1) or p21(waf1). It inhibited mitogen activated protein kinase (MAPK) and Akt activity, as well as the mammalian target of rapamycin (mTOR) in both ER positive and negative, erbB2-overexpressing and erbB2-normal expressing breast cancer cells. In erbB2-overexpressing breast cancer cell lines, metformin reduced erbB2 expression at higher concentrations, and at lower concentrations within the therapeutic range, it inhibited erbB2 tyrosine kinase activity evidenced by a reduction of phosphorylated erbB2 (P-erbB2) at both auto- and Src- phosphorylation sites. These data suggest that metformin may have potential therapeutic utility against ER positive and negative, erbB2-overexpressing and erbB2-normal expressing breast cancer cells.
[Preventive and therapeutic effects of radix Salviae miltiorrhizae on glycerol-induced acute renal failure in rats]. (1997)

Three substances obtained from Radix Salviae Miltiorrhizae were administered to rats with acute renal failure (ARF) induced by intramuscular injection of glycerol. The rats treated with the substances had significantly lower serum urea and creatinine levels than the untreated animals. In the treated group, the survival percentage was higher than that in the untreated group. Examination of kidneys showed that the treated group had significantly lighter renal damage than the untreated group. These results suggest that the three substances exert preventive and therapeutic effects on the ARF in rats and the effects are probably the result of adenosine antagonism.
Metal Foam Production Process Using Hydro-Gel and its Improvement (2007)

Already, we are developing the process to produce stainless steel foam over 97% porosity using hydro-gel binder. However, this process is very sensitive process, and foaming condition is affected by the slight deference of heating temperature. Therefore, we tried to improve the process by changing the foaming agent and foaming conditions. By the improvement of the process, the foaming operation becomes stable and finer cell size stainless steel foam can be obtained.
Worst-case timing prediction of relay ladder logic by constraint analysis (2002)

In this paper, we propose a technique of predicting the execution time of PLC application programs written in relay ladder logic. The proposed technique divides an RLL program into several RLL blocks and then transforms them into boolean logic equations. The internal states of an RLL program is analyzed and their dependencies are used as constraints when we solve the boolean logic equations. The plant information represented by exclusiveness of input contacts is also used as constraints. The constraint analysis reduces the complexity of logic programming as well as the worst-case timing prediction. The algorithm for partitioning variables in the logic equations is developed to reduce the complexity further.
Trends in therapy of abnormal airway epithelial ion and liquid transport. (1993)

Airway epithelial ion transport, particularly that of sodium and chloride, influences the volume and composition of airway surface liquid. Defects in ion transport play an important role in the pathogenesis of some chronic airway diseases, for example cystic fibrosis. New aerosolised therapies that modulate defects in ion transport, and hence influence the natural history of cystic fibrosis are currently undergoing scrutiny. Agents such as sodium channel inhibitors and chloride channel activators are included in this class.
SARS Antibody Test for Serosurveillance (2004)

A peptide-based enzyme-linked immunosorbent assay (ELISA) can be used for retrospective serosurveillance of severe acute respiratory syndrome (SARS) by helping identify undetected chains of disease transmission. The assay was developed by epitope mapping, using synthetic peptides from the spike, membrane, and nucleocapsid protein sequences of SARS-associated coronavirus. The new peptide ELISA consistently detected seroconversion by week 2 of onset of fever, and seropositivity remained through day 100. Specificity was 100% on normal blood donor samples, on serum samples associated with infection by other pathogens, and on an interference panel. The peptide-based test has advantages of safety, standardization, and automation over previous immunoassays for SARS. The assay was used for a retrospective survey of healthy healthcare workers in Taiwan who treated SARS patients. Asymptomatic seroconversions were detected in two hospitals that had nosocomial disease.
Spectral characterization of tracheal and esophageal tissues using a hyperspectral camera and fiber optic sensors (2016)

During emergency medical situations where the patient has an obstructed airway or necessitates respiratory support, endotracheal intubation (ETI) is the medical technique of placing a tube into the trachea in order to facilitate adequate ventilation of the lungs. In particular, the anatomical, visual and time-sensitive challenges presented in these scenarios, such as in trauma, require a skilled provider in order to successfully place the tube into the trachea. Complications during ETI such as repeated attempts, failed intubation or accidental intubation of the esophagus can lead to severe consequences or ultimately death. Consequently, a need exists for a feedback mechanism to aid providers in performing successful ETI. To investigate potential characteristics to exploit as a feedback mechanism, our study examined the spectral properties of the trachea tissue to determine whether a unique spectral profile exists. In this work, hyperspectral cameras and fiber optic sensors were used to capture and analyze the reflectance profiles of tracheal and esophageal tissues illuminated with UV and white light. Our results show consistent and specific spectral characteristics of the trachea, providing foundational support for using spectral properties to detect features of the trachea.
Clock Skew Scheduling Under Process Variations (2006)

Process variation may lead to chip fail because of the property variation of its datapath and clock network. We consider the problem of finding an optimal clock schedule, which has not only the minimal clock period but also the maximal tolerant to process variation. Clock skew scheduling is modeled as a constraint difference system, which can be solved by graph theory. The basic traditional algorithm has the vulnerability that the skew value is near to the skew constraint boundary. The parametric shortest path algorithm inserts unified margin value in the skew constraint with loss of circuit performance. We present an approach that can maximize the safe margin during clock skew scheduling, which is evaluated by center error square index. Experimental results show that our incremental slack distribution algorithm has the optimal clock skew scheduling result with more safe margin and has more robust tolerant to process variation.
Comparing Vessel Trajectories Using Geographical Domain Knowledge and Alignments (2010)

This paper presents a similarity measure that combines low-level trajectory information with geographical domain knowledge to compare vessel trajectories. The similarity measure is largely based on alignment techniques. In a clustering experiment we show how the measure can be used to discover behavior concepts in vessel trajectory data that are dependent both on the low-level trajectories and the domain knowledge. We also apply this measure in a classification task to predict the type of vessel. In this task the combined measure performs better than similarities based on domain knowledge or low-level information alone.
High-speed interferometric measurement of aerodynamic phenomena (1990)

The cross-sections of high-speed aerodynamic phenomena are presently measured by means of a system that interferometrically ascertains optical path length changes with high spatial resolution. Attention is given to the optical disturbance through an aerocurtain, and to the shock wave produced by a hypersonic projectile. While the slowest repetition rate of the laser, camera, and data recorder determines the time-frame rate, the combination of the camera and data recorder determines the spatial resolution. The technique is the spatial equivalent of phase-shifting interferometry. The real-time hardware employed is discussed.
Low voltage performance of a microwave CMOS Gilbert cell mixer (1997)

This paper demonstrates the low voltage operation of a doubly balanced Gilbert mixer fabricated in a 0.8-/spl mu/m CMOS process and operating as both a down-converter and an up-converter. As a down-converter with an RF input of 1.9 GHz, the mixer has a single sideband noise figure as low as 7.8 dB and achieved down-conversion gain for supply voltages as low as 1.8 V. As an up-converter, the mixer demonstrates 10 dB of conversion gain at an RF frequency of 2.4 GHz with an applied local oscillator (LO) power of -7 dBm and LO-RF/LO-IF isolation of at least 30 dB. Up-conversion gain was achieved over a 5-GHz bandwidth and at supply voltages as low as 1.5 V. The mixer presented demonstrates the lowest single side band noise figure for a CMOS doubly balanced down-converting mixer and the highest frequency of operation for a mixer fabricated in CMOS technology to date.
CpG DNA rescues B cells from apoptosis by activating NFκB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway (1999)

Isolated murine splenic B cells gradually undergo spontaneous apoptosis while WEHI-231 B lymphoma cells undergo activation-induced apoptosis. Unmethylated CpG dinucleotides in a particular sequence context (CpG motif) in bacterial DNA or in synthetic oligodeoxynucleotides (CpG DNA) rescue both splenic B cells and WEHI-231 cells from apoptosis, an effect which could potentially contribute to autoimmune disease. Chloroquine has been used as an effective therapeutic agent for some autoimmune diseases, although the mechanism of action is not clearly understood. Low concentrations of chloroquine (<5 microM) selectively abolished CpG DNA-mediated protection against spontaneous apoptosis of splenic B cells and against anti-IgM-induced apoptosis of WEHI-231 cells without affecting anti-apoptotic activities of anti-CD40 or lipopolsaccharide. CpG DNA effectively prevented mitochondrial membrane potential disruption through a chloroquine-sensitive pathway in splenic B cells. Apoptosis protection by CpG DNA was also associated with increased expression of several proto-oncogenes and oncoproteins directly and/or indirectly through a rapid and sustained activation of NFkappaB in splenic B cells and WEHI-231 cells. These effects were also suppressed by chloroquine. Our results suggest that despite the difference in maturation phenotype of splenic B cells and WEHI-231 cells, CpG DNA rescues both from apoptosis by similar pathway, which is blocked at an early step by chloroquine.