gebhart/patrepeval huggingface dataset:
Studies on Peroxisomes (1980)

Treatment with 1,3-propanediol-bis(2-p-chlorophenoxy-isobutyrate) (simfibrate), a hypolipidemic drug, showed little effect on liver weight and hepatic lipid level. When the effects of simfibrate on rat liver peroxisomal enzymes were examined, it was found that cyanide-insensitive fatty acyl-CoA oxidizing system and carnitine acetyltransferase activity increased from 0.38 U/g liver to 4.5 U/g liver and from 227 U/g liver to 6,450 U/g liver, respectively. The activity of D-amino acid oxidase decreased from 1.05 U/g liver to 0.39 U/g liver. Other peroxisomal enzymes including catalase and urate oxidase were not significantly changed by this drug. Of the protein components of the light mitochondrial fraction of simfibrate-treated rat liver, a polypeptide with a molecular weight of approximately 76,000, which has been suggested to be one of the peroxisomal proteins, increased in the treated rat liver (as estimated by sodium dodecylsulfate-polyacrylamide gel electrophoresis) and DL-[4,5-3H]leucine-incorporation into this particular component was also stimulated to a level about 3 times that of the control.
A UHF ultrabroadband vivaldi-type direction finding antenna (2010)

A modern state of the art direction finder system consists of several direction finding (DF) antennas and the direction finder electronics. In order to achieve most accurate results for all azimuth directions the direction finder antenna system is often built using a circular antenna array. The need for light weight mobile DF systems leads to smaller DF antenna designs using less frequency bands to cover the whole frequency range. In this paper, an ultrabroadband DF antenna array covering the whole UHF frequency range from 0.3 GHz to 3 GHz is introduced. Unlike the common antenna designs using dipols [I, 2] the new design consists often vivaldi-type antenna elements to cover the UHF frequency range fully.
EGF receptor signaling induces <i>pointed P1</i> transcription and inactivates Yan protein in the <i>Drosophila</i> embryonic ventral ectoderm (1996)

ABSTRACT The induction of different cell fates along the dorsoventral axis of the Drosophila embryo requires a graded activity of the EGF receptor tyrosine kinase (DER). Here we have identified primary and secondary target genes of DER, which mediate the determination of discrete ventral cell fates. High levels of DER activation in the ventralmost cells trigger expression of the transcription factors encoded by ventral nervous system defective (vnd) and pointed P1 (pntP1). Concomitant with the induction of pntP1, high levels of DER activity lead to inactivation of the Yan protein, a transcriptional repressor of Pointed-target genes. These two antagonizing transcription factors subsequently control the expression of secondary target genes such as otd, argos and tartan. The simultaneous effects of the DER pathway on pntP1 induction and Yan inactivation may contribute to the definition of the border of the ventralmost cell fates.
Polymers for biodegradable medical devices. X. Microencapsulation studies: control of poly-hydroxybutyrate-hydroxyvalerate microcapsules porosity via polycaprolactone blending (1993)

Reservoir-type microcapsules were prepared using a double emulsion solvent evaporation process from a range of different poly-beta-hydroxybutyrate homopolymers and copolymers thereof with 3-hydroxyvalerate (P(HB-HV) polymers) blended with 20 per cent by weight of poly-epsilon-caprolactone (PCL). Microcapsules prepared from these P(HB-HV)/20 per cent PCL blends had very different typical surface morphologies from those prepared from the corresponding unblended P(HB-HV) polymers. At this blend ratio the effects of polymer blending on particle morphology were clearly dependent on the molecular weight of P(HB-HV) polymer and, to a reduced extent, the 3-hydroxyvalerate content. Microcapsules were also prepared from blends of a high molecular weight P(HB-HV) polymer with PCL in which the proportion of the latter was varied from 0 to 100 per cent at 10 per cent intervals. Increasing the proportion of PCL from 0 to 50 per cent produced a systematic and dramatic increase in microcapsule porosity; with only skeletal particles being generated from the even 50-50 blend. When the proportion of PCL in the blends was increased from 50 to 70 per cent the level of particle porosity diminished, and at 80 per cent or above the microcapsules were essentially smooth and non-porous.
Comparison of subcellular proteins of normal prostate, benign prostatic hypertrophy, and prostatic cancer: Presence of BPH‐associated nonhistone proteins (1985)

Proteins in the cytosol, postnuclear particulate, and nuclear fractions from seven specimens of normal prostate from bladder cancer patients, 14 specimens of benign hypertrophic prostate (BPH), and three specimens of cancerous prostate were analyzed and compared by SDS-polyacrylamide slab gel electrophoresis. Abundant protein species in the cytosol fractions were 60K (species having a molecular weight of about 60,000) and 42K; their relative contents were about 35% for 60K and about 12% for 42K. In the postnuclear particulate fraction, 42K was the most abundant (about 10% of the total). The contents of these major protein species were similar in specimens of normal and diseased prostates. In addition, there are marked similarities in the electrophoretic patterns for all the protein (24-29 species) in the cytosol and postnuclear particulate fractions of the human prostate, except for four minor species in the cytosol fraction. Of the nuclear proteins, the content of core histones (H2A, H2B, H3, and H4) was fundamentally similar among all the specimens, whereas the content of H1 histone was different from one specimen to another. The most remarkable and significant difference was that the 42K-NHP (nonhistone protein having a molecular weight of about 42,000), 55K-NHP, and 190K-NHP concentrations were significantly higher in BPH than in normal and cancerous prostates.
Trial of Baclofen in Amyotrophic Lateral Sclerosis (1979)

A trial of the antispastic drug baclofen was made in amyotrophic lateral sclerosis. Some patients noted reduction of tonus and spasticity; but others had no benefit, nor was the course of the disease altered by long-term administration of baclofen. No major side effects occurred.
New PAPR-preserving mapping methods for single-carrier FDMA with space-frequency block codes (2009)

Innovative mapping schemes for Space-Frequency Block Codes (SFBC) which are compatible with the structure of Single-Carrier Frequency Division Multiple Access (SC-FDMA) systems are introduced. We first show that existing space-time and space-frequency block codes lack flexibility in terms of framing or cause a degradation of the signal envelope properties when combined with SC-FDMA. Then, we present an Alamoutibased orthogonal code designed for 2 transmit antennas that makes use of an innovative mapping in the frequency domain to preserve the low envelope properties of SC-FDMA. Next, an extension of this concept to a quasi-orthogonal code for 4 transmit antennas is presented and analyzed. We prove the good performance of the proposed schemes over multiple-input multiple-output (MIMO) channels both in static and in highmobility scenarios.
Urinary Lipid Profiling for the Identification of Fabry Hemizygotes and Heterozygotes (2005)

These lipid profiles hold particular promise for the identification of Fabry individuals, may aid in the prediction of phenotype, and are potentially useful for the monitoring of therapy in patients receiving enzyme replacement.
Degradation of polyethylene during extrusion. II. Degradation of low‐density polyethylene, linear low‐density polyethylene, and high‐density polyethylene in film extrusion (2004)

When this article was published, Figure 5 was printed incorrectly. It is shown here (see next page) in its correct form. (A) Molecular mass (M̄w) and polydispersity (M̄n/M̄w) for LDPE as function of exposure time, air gap, and extrusion process temperature (⧫ 260, ▪ 280, and ▴ 325°C). The value at 0 mm air gap represents the starting material. (B) Molecular mass (M̄w) and polydispersity (M̄n/M̄w) for LLDPE as function of exposure time, air gap, and extrusion process temperature (⧫ 260, ▪ 280, and ▴ 325°C). The value at 0 mm air gap represents the starting material. (C) Molecular mass (M̄w) and polydispersity (M̄n/M̄w) for HDPE as function of exposure time, air gap, and extrusion process temperature (⧫ 260, ▪ 280, and ▴ 325°C). The value at 0 mm air gap represents the starting material.
Electron-beam cell projection lithography: Its accuracy and its throughput (1994)

The cell projection electron-beam lithography system HL-800D has been developed for 0.2 μm ultralarge scale integration circuit and application specific integrated circuit use. This system is formed by a conventional variable shaped beam and cell beams for using five apertures. To achieve high resolution and high-stitching accuracy between the cell beams, and between variable shaped beam and cell beam, we developed the automatic tuning method for cell beams. Included in the method are: (1) rotation and magnification correction, (2) beam alignment for cell beams, (3) space-charge effect correction, and (4) mask position alignment. This method realized a system for easy handling of cell projection tuning. As a result, stitching accuracy under 0.05 μm and resolution under 0.2 μm for cell beams have been achieved. The contact hole layer and the wiring layer of a 0.35 μm DRAM pattern have been overlaid with an accuracy of 0.04 μm (maximum value).
Characterization of coherent quantum frequency combs using electro-optic phase modulation (2018)

We demonstrate a two-photon interference experiment for phase coherent biphoton frequency combs (BFCs), created through spectral amplitude filtering of biphotons with a continuous broadband spectrum. By using an electro-optic phase modulator, we project the BFC lines into sidebands that overlap in frequency. The resulting high-visibility interference patterns provide an approach to verify frequency-bin entanglement even with slow single-photon detectors; we show interference patterns with visibilities that surpass the classical threshold for qubit and qutrit states. Additionally, we show that with entangled qutrits, two-photon interference occurs even with projections onto different final frequency states. Finally, we show the versatility of this scheme for weak-light measurements by performing a series of two-dimensional experiments at different signal-idler frequency offsets to measure the dispersion of a single-mode fiber.
Milestones Toward 50% Efficient Solar Cell Modules (2007)

Abstract : The Very High Efficiency Solar Cell (VHESC) program is developing integrated optical system - PV modules for portable applications that operate at greater than 50 percent efficiency. We are integrating the optical design with the solar cell design, and have entered previously unoccupied design space. Our approach is driven by proven quantitative models for the solar cell design, the optical design and the integration of these designs. Optical systems efficiency with an optical efficiency of 93% and solar cell device results summing to 42.9% are described. Keywords: High performance, module architecture, solar cell efficiency.
Gene expression profiling in primary breast cancer distinguishes patients developing local recurrence after breast-conservation surgery, with or without postoperative radiotherapy (2008)

A highly distinct gene expression profile for patients developing local recurrence after breast-conservation surgery despite radiotherapy has been identified. If verified in further studies, this profile might be a most important tool in the decision making for surgery and adjuvant therapy.
Ethnomedicines used in Trinidad and Tobago for reproductive problems (2007)

Native Caribbean plants have been less studied that those from Africa, India and Europe. Chamaesyce hirta has scientific support but as a diuretic. Other plants with level 3 validity for reproductive issues are: Achyranthes indica, Coleus aromaticus, Hibiscus rosa-sinesis, Parthenium hysterophorus and Ruta graveolens. The non-experimental validation method can be used to advise the public on which plants are safe, effective and useful, and which are not; pending clinical trials. This is especially important since so few clinical trials are conducted on Caribbean plants.
A GaAs data switching IC for a gigabits per second communication system (1986)

A GaAs monolithic 4/spl times/4 switching circuit has been developed for high-speed digital communication systems. This switching IC, which has built-in address decoders, is completely ECL-compatible. Dynamic performance measurements on the chip mounted in a 32-pin flat package prove that it correctly switches pseudorandom data transmitted at more than 2 Gb/s, switching in 1 ns. The pulsewidth variation is only /spl plusmn/60 ps at 2 Gb/s. Very stable operation is observed from 0 to 70/spl deg/C ambient temperature for supply voltage fluctuations of /spl plusmn/5%.
One-Flask Preparation of Symmetrical Ketones and 1,2-Diketones from Esters (1991)

A convenient one-flask preparation of a series of symmetrical 1,2diketones from esters is reported using sodium metal induced acyloin condensation followed by reaction with thionyl chloride. Symmetrical monoketones were obtained when after initial acyloin condensation, the reaction mixture is oxidized with aqueous sodium bromate and then reacted with thionyl chloride. Preparative aspects, the scope of the reaction, and the suggested mechanism are discussed.
[Clinical and experimental study on treatment of retention enema for chronic non-specific ulcerative colitis with quick-acting kuijie powder]. (1999)

Retention enema with QAKJP has good effect on CUC, low recurrence rate and no toxic and side effect.
Exemplar-Supported Representation for Effective Class-Incremental Learning (2020)

Catastrophic forgetting is a key challenge for class-incremental learning with deep neural networks, where the performance decreases considerably while dealing with long sequences of new classes. To tackle this issue, in this paper, we propose a new exemplar-supported representation for incremental learning (ESRIL) approach that consists of three components. First, we use memory aware synapses (MAS) pre-trained on the ImageNet to retain the ability of robust representation learning and classification for old classes from the perspective of the model. Second, exemplar-based subspace clustering (ESC) is utilized to construct the exemplar set, which can keep the performance from various views of the data. Third, the nearest class multiple centroids (NCMC) is used as the classifier to save the training cost of the fully connected layer of MAS when the criterion is met. Intensive experiments and analyses are presented to show the influence of various backbone structures and the effectiveness of different components in our model. Experiments on several general-purpose and fine-grained image recognition datasets have fully demonstrated the efficacy of the proposed methodology.
Dynamic Processes of Supercavitation and Computer Simulation (2001)

This lecture is devoted to unsteady processes in the flows with natural and artificial supercavitation. We consider two classes of phenomena: (1) forced non-stationarity of the flow which is induced by external causes - a model velocity change an ambient pressure impulse a variation of gas supply into a cavity etc.; and (2) self-exited oscillation arising due to internal instability of gas-filled supercavities. Results of computer simulation of the dynamic supercavitation processes are presented. They were obtained by using the approximate mathematical model based on the G. Logvinovich independence principle of the supercavity expansion. A comparison of unsteady behavior of axisymmetric and two-dimensional supercavities is given. Formulation and solution of two 2-D problems are presented: (1) the problem on instability of the 2-D gas-filled supercavity; and (2) the problem on evolution of the 2-D supercavity past an oscillating wedge. The solutions are based on the M. Tulin's linearized cavitation scheme. The lecture material is illustrated by sequences of motion-picture flames and photographs of the unsteady supercavitation processes. They were obtained at the hydrodynamic laboratory of the Institute of Hydromechanics of NAS of Ukraine (IHM UNAS).
Letter: Ischemic heart disease, water hardness and myocardial magnesium. (1975)

In 54 cases of accidental death in cities with water hardness of 60 parts per million (ppm) or less, the mean myocardial magnesium concentration was 918 mug/g of dry tissue. This was 7% lower than the corresponding figure of 982 mug/g among 29 cases of accidental death in cities with water hardness of 300 ppm or more, and this difference was significant (P less than 0.01). There were no significant differences between the cities with soft and hard water in the mean myocardial concentrations of calcium, zinc, copper, chromium, lead or cadmium. These results are compatible with the belief that the relatively high death rates in some soft-water areas may be due to a suboptimal intake of magnesium, and that water-borne magnesium exerts a protective effect on the residents of hard-water areas.
Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity (1986)

Mutations that eliminated the ability of the human T-cell lymphotropic virus type III to produce the 27-kilodalton 3' orf product did not eliminate the ability of the virus to replicate in and kill T4+ cells. A mutant carrying a mutation that deleted carboxy-terminal sequences from the envelope gene as well as the 3' orf sequences retained the ability to kill T4+ lymphocytes, but had a retarded replication rate.
Control point assessment for image registration (2003)

Presents several extensions of the basic control point assessment (CPA) algorithm. First, we compare CPA to standard corner detection algorithms and then turn to the question of selecting control points with adequate dispersion, since this is crucial for accurate registration. Two selection methods are proposed. The first consists of clustering the control points via the Lloyd algorithm (S.P. Lloyd, 1957, 1982) followed by selecting the dominant control point in each cluster. This "gold standard" approach produces excellent dispersion but is costly in terms of computational effort. The second selection method consists of subdividing the image and then selecting dominant control points in each subdivision. This is extremely fast and produces results comparable to the Lloyd selection method. The paper concludes with a discussion of how least-squares operator norm information can be coupled with anisotropic diffusion to produce smoothed images without corner degradation.
Systematic Urokinase-Activated Anthrax Toxin Therapy Produces Regressions of Subcutaneous Human Non–Small Cell Lung Tumor in Athymic Nude Mice (2007)

The novel recombinant anthrax toxin, PrAgU2/FP59, composed of the urokinase-activated protective antigen and a fusion protein of Pseudomonas exotoxin and lethal factor was tested for anti-lung cancer efficacy in an in vivo human tumor model. Male athymic nude mice (age 4-6 weeks) were inoculated s.c. with 10 million H1299 non-small cell lung cancer (NSCLC) cells in the left flank. When tumor volumes reached 200 mm(3) (6-8 days), i.p. injection of 100 muL saline or different ratios and doses of PrAgU2/FP59 in 100 muL saline were given every 3 days for four doses and an additional dose at day 29. Animals were monitored twice daily and tumor measurements were made by calipers. The maximum tolerated doses of PrAgU2/FP59 differed dependent on the ratios of PrAgU2 to FP59 over the range of 3:1 to 25:1, respectively. At tolerated doses, tumor regressions were seen in all animals. Complete histologic remission lasting 60 days occurred in 30% of animals. PrAgU2/FP59 showed dramatic anti-NSCLC efficacy and warrants further clinical development for therapy of patients with advanced NSCLC.
Analyzing three-dimensional ultrastructure of human cervical tissue using optical coherence tomography (2015)

During pregnancy, the uterine cervix is the mechanical barrier that prevents delivery of a fetus. The underlying cervical collagen ultrastructure, which influences the overall mechanical properties of the cervix, plays a role in maintaining a successful pregnancy until term. Yet, not much is known about this collagen ultrastructure in pregnant and nonpregnant human tissue. We used optical coherence tomography to investigate the directionality and dispersion of collagen fiber bundles in the human cervix. An image analysis tool has been developed, combining a stitching method with a fiber orientation measurement, to study axially sliced cervix samples. This tool was used to analyze the ultrastructure of ex-vivo pregnant and non-pregnant hysterectomy tissue samples taken at the internal os, which is the region of the cervix adjacent to the uterus. With this tool, directionality maps of collagen fiber bundles and dispersion of collagen fiber orientation were analyzed. It was found that that the overall preferred directionality of the collagen fibers for both the nonpregnant and pregnant samples were circling around the inner cervical canal. Pregnant samples showed greater dispersion than non-pregnant samples. Lastly, we observed regional differences in collagen fiber dispersion. Fibers closer to the inner canal showed more dispersion than the fibers on the radial edges.
The Halpin‐Tsai equations: A review (1976)

Abstract The Halpin‐Tsai equations are based upon the “self‐consistent micromechanics method” developed by Hill. Hermans employed this model to obtain a solution in terms of Hill's “reduced moduli”. Halpin and Tsai have reduced Hermans' solution to a simpler analytical form and extended its use for a variety of filament geometries. The development of these micromechanic's relationships, which form the operational bases for the coniposite analogy of Halpin and Kardos for semi‐crystalline polymers, are reviewed herein.
Interacting domains of E2F1, DP1, and the adenovirus E4 protein (1994)

Recent experiments demonstrate that a family of related proteins constitute the E2F transcription factor activity and that the interaction of two of these gene products, E2F1 and DP1, generates a heterodimer with DNA binding and transcriptional activating capacity. Previous experiments have shown that the adenovirus E4 19-kDa protein facilitates the formation of a stable E2F dimer on the adenovirus E2 promoter. We now show that coexpression of the E2F1 and DP1 products in transfected SAOS-2 cells, together with the E4 product, generates a multicomponent complex with specificity to the adenovirus E2 promoter. Using a yeast two-hybrid assay system, we find that the E2F1 hydrophobic heptad repeat (E2F1 amino acid residues 206 to 283) allows interaction with a corresponding domain of the DP1 protein (amino acids 196 to 245). We also find that the adenovirus E4 protein interacts with the DP1 hydrophobic heptad repeat domain, but we could not detect a direct interaction between E2F1 and E4. Additional assays demonstrate that the E4 protein can dimerize. Since our previous experiments have shown that mutations within the E2F1 hydrophobic heptad repeat element abolish the E4-mediated transcription enhancement in transfection assays, we conclude that the E4 protein likely interacts with the E2F1-DP1 heterodimer by directly binding to the DP1 product. As a consequence of the ability of E4 to dimerize, we propose that the stable complex formed on the two E2F sites within the E2 promoter is composed of two E2F1-DP1 heterodimers held together by an E4 dimer.