gebhart/patrepeval huggingface dataset:
Oracle essentials : Oracle9i, Oracle8i, and Oracle8. (2001)

Preface. 1. Introducing Oracle The Evolution of the Relational Database The Oracle Family Summary of Oracle Features Database Application Development Features Database Connection Features Distributed Database Features Data Movement Features Performance Features Database Management Features Oracle Internet Developer Suite Oracle Lite. 2. Oracle Architecture Instances and Databases The Components of a Database The Components of an Instance The Data Dictionary. 3. Installing and Running Oracle Installing Oracle Creating a Database Configuring Oracle Net/Net8 Starting Up the Database Shutting Down the Database Accessing a Database Oracle at Work. 4. Data Structures Datatypes Basic Data Structures Additional Data Structures Data Design Constraints Triggers Query Optimization Understanding the Execution Plan Data Dictionary Tables. 5. Managing Oracle Implementing Security Management Through the Oracle Enterprise Manager Options for Oracle Enterprise Manager Fragmentation and Reorganization Backup and Recovery Working with Oracle Support. 6. Oracle Performance Performance Tuning Basics Oracle and Disk I/O Resources Oracle and Parallelism Oracle and Memory Resources Oracle and CPU Resources Avoiding Performance Problems with Oracle9i Real Application Clusters and Performance. 7. Multiuser Concurrency Basics of Concurrent Access Oracle and Concurrent User Access Oracle's Isolation Levels Oracle Concurrency Features How Oracle Handles Locking Concurrent Access and Performance Workspaces. 8. Oracle and Transaction Processing OLTP Basics Oracle's OLTP Heritage Architectures for OLTP Oracle Features for OLTP High Availability Oracle Advanced Queuing Object Technologies and Distributed Components. 9. Oracle and Data Warehousing Data Warehousing Basics Data Warehouse Design Query Optimization OLAP in the Database Managing the Data Warehouse Other Data Warehouse Software The Metadata Challenge Best Practices. 10. Oracle and High Availability What Is High Availability? System Crashes Protecting Against System Crashes Recovering from Disasters Complete Site Failure Data Redundancy Solutions. 11. Oracle and Hardware Architecture System Basics Uniprocessor Systems Symmetric Multiprocessing Systems Clusters Massively Parallel Processing Systems Nonuniform Memory Access Systems Disk Technology Which Hardware Solution? 12. Distributed Databases and Distributed Data Accessing Multiple Databases as a Single Entity Two-Phase Commits Moving Data Between Distributed Systems Advanced Queuing. 13. Extending Oracle Datatypes Object-Oriented Development Extensibility Features and Options Using the Extensibility Framework in Oracle. 14. Oracle and the Web The Internet Computing Platform Oracle as an Internet Server XML Dynamic Services Oracle Internet Application Server Oracle9iAS Portal. A. What's New in This Book for Oracle9i. B. Additional Resources. Index
Biosynthesis of K88 fimbriae in Escherichia coli: interaction of tip-subunit FaeC with the periplasmic chaperone FaeE and the outer membrane usher FaeD. (2001)

K88 fimbriae are ordered polymeric protein structures at the surface of enterotoxigenic Escherichia coli cells. Their production and assembly requires a molecular chaperone located in the periplasm (FaeE) and a molecular usher located in the outer membrane (FaeD). FaeC is the tip component of the K88 fimbriae. We studied the expression of the subcloned faeC gene, the subcellular localization of FaeC and its interaction with the chaperone and the outer membrane usher. In the absence of the chaperone or the usher, FaeC could not be detected in E. coli cells harbouring the faeC gene and its ribosome binding site under contol of the IPTG inducible lpp/lac promoter/operator. The expression of FaeC was detectable in the presence of chaperone FaeE, but a direct interaction between the chaperone and FaeC was not found. The expression of FaeC was also detectable in cells co-expressing the outer membrane usher FaeD. Overexpression of FaeC after changing the faeC ribosome binding site appeared to induce lethality. Expression of subcloned FaeC in the absence of FaeE or FaeD could be detected when faeC was cloned under the tight control of the ara promoter/operator and when lethality induction was avoided. The direct interaction of FaeC with outer membranes containing the usher FaeD was studied by cell fractionation, isopycnic sucrose density gradient centrifugation, SDS-PAGE and immunoblotting. FaeC was found to bind to outer membranes containing FaeD or a FaeD-PhoA hybrid construct containing 215 amino-terminal residues of FaeD. This binding was not observed when control outer membranes without FaeD were used. No other K88 specific proteins were required for this interaction. The direct interaction between FaeC and FaeD in the outer membranes was shown by affinity blotting experiments. FaeE was not required for this interaction. Together these data indicate that the minor fimbrial subunit FaeC, unlike FaeG, H and F, does not have a strong interaction with the chaperone FaeE in the E. coli periplasm, but directly binds to the outer membrane molecular usher FaeD.
Pathway and Evolutionary Implications of Diphenylamine Biodegradation by <i>Burkholderia</i> sp. Strain JS667 (2009)

Diphenylamine (DPA) is a common contaminant at munitions-contaminated sites as well as at aniline manufacturing sites. Little is known about the biodegradation of the compound, and bacteria able to use DPA as the growth substrate have not been reported. Burkholderia sp. strain JS667 and Ralstonia sp. strain JS668 were isolated by selective enrichment from DPA-contaminated sediment. The isolates grew aerobically with DPA as the sole carbon, nitrogen, and energy source. During induction of DPA degradation, stoichiometric amounts of aniline accumulated and then disappeared, which suggested that aniline is on the DPA degradation pathway. Genes encoding the enzymes that catalyze the initial steps in DPA degradation were cloned from the genomic DNA of strain JS667. The Escherichia coli clone catalyzed stoichiometric transformation of DPA to aniline and catechol. Transposon mutagenesis, the sequence similarity of putative open reading frames to those of well-characterized dioxygenases, and (18)O(2) experiments support the conclusion that the initial reaction in DPA degradation is catalyzed by a multicomponent ring-hydroxylating dioxygenase. DPA is converted to aniline and catechol via dioxygenation at the 1,2 position of the aromatic ring and spontaneous rearomatization. Aniline and catechol are further biodegraded by the well-established aniline degradation pathway. Genes that encode the complete aniline degradation pathway were found 12 kb downstream of the genes that encode the initial dioxygenase. Expression of the relevant dioxygenases was confirmed by reverse transcription-PCR analysis. Both the sequence similarity and the gene organization suggest that the DPA degradation pathway evolved recently by the recruitment of two gene clusters that encode the DPA dioxygenase and aniline degradation pathway.
Female Apparel Consumers’ Understanding of Body Size and Shape (2013)

This study assessed the reliability of the self-perceived lower-body size and shape using 3D body-scanning technology. Comparison of each participant's measurements on the relevant variables to categorized Size USA data provided a method of identifying where an individual is placed in relation to the population. Comparing perceptions (survey results) to actual placement in the population (derived from a participant's 3D body measurements) gave insight into how different categories of participants viewed themselves and how valid their self-assessments were at various locations on the body. This study also analyzed the relationship between garment fit satisfaction, body cathexis, and self-perception of lower-body size and shape for each body location because apparel companies have had difficulty in understanding fit from a consumer's perspective. The researchers expect that the analyses of the influences of body cathexis and body perceptions on fit satisfaction can help apparel companies further understand their customers' fit satisfaction goals.
Synthetic aperture imaging in medical ultrasound with correction for motion artifacts (2002)

The authors state that a synthetic receive aperture (SRA) system of a relatively simple design could increase the resolution of a phased-array imaging system several-fold, by utilizing a given number of parallel receive channels to address a larger number of transducer elements through multiplexers. A 1*N phased array can be extended linearly to improve lateral resolution, or it can be split into an M*N array in order to improve resolution in the elevation dimension. Images from an SRA system are degraded by any tissue/transducer motion during data acquisition. This degradation can be corrected by estimating the axial component of the motion and then realigning the data. A cross-correlation technique, which detects the phase difference between two similar lines of RF data (one for each receive subaperture), is used to perform this correction. The results of a theoretical analysis, of simulations, and of laboratory experiments are presented to demonstrate the advantages of using SRA compared to using conventional phased-array imaging.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Extraction of Unloaded Q and Coupling Matrix From Measurements on Filters With Large Losses (2010)

In this letter, a simple solution is described for obtaining an accurate evaluation of the coupling matrix and the unloaded Q from the measured scattering parameters of a microwave lossy filter (assuming all the resonators with the same unloaded Q). The Cauchy method is applied in a predistorted frequency domain, where the measured (lossy) parameters refer to a lossless device. In this way, it becomes possible to synthesize a prototype low-pass network using well established techniques, once the topology of the filters has been assigned. With respect to the previous methods available in the literature, the one here proposed allows very accurate results even with filters exhibiting large insertion losses; moreover the computing time is extremely short allowing the use of the method in real time computer-aided tuning procedures for microwave filters. An example of application of the proposed method is reported in the letter for illustrative and validating purposes.
Overview of molecular mechanisms in chagasic cardioneuromyopathy and achalasia. (1999)

Evidence accumulated by our investigations over the years give adequate proof for the existence of circulating antibodies in Chagas disease which bind to beta adrenergic and muscarinic cholinergic receptor of myocardium. The interaction of agonist-like antibodies with neurotransmitter receptors, triggers in the cells intracellular signal transductions that alter the physiological behaviour of the target organs. These events convert the normal cells into pathologically active cells. The interaction of antibodies with heart beta adrenergic and cholinergic receptors triggers physiologic, morphologic, enzymatic and molecular alterations, leading to tissue damage. The analysis of the prevalence and distribution of these antibodies reveals a strong association with cardiac and esophageal autonomic dysfunction in seropositive patients in comparison with those without alteration of the heart and esophagus autonomic disorders: therefore, the presence of these antibodies may partially explain the cardiomyoneurophathy and achalasia of Chagas disease, in which the sympathetic and parasympathetic systems are affected. The deposit of autoantibodies behaving like an agonist on neurotransmitter receptors, induceds desensitization and/or down regulation of the receptors. This in turn, could lead to a progressive blockade of neurotransmitter receptors, with sympathetic and parasympathetic dennervation, a phenomenon that has been described during the course of Chagas cardioneuropathy and achalasia. The clinical relevance of these findings is the demonstration, using biomolecules, of a strong association between the existence of circulating autoantibodies against peptides corresponding to the second extracellular loop of the human heart beta, adrenoceptor and M2 cholinoceptor in chagasic patients, and the presence of dysautonomic symptoms, making these autoantibodies a proper early marker of heart and digestive autonomic dysfunction.
Electrophysiological studies of acetylcholine and the role of the basal forebrain in the somatosensory cortex of the cat. II. Cortical neurons excited by somatic stimuli (1990)

1. Of the sample of 322 neurons located in somatosensory cortex and tested for their responsiveness to somatic stimulation, 91 (28%) responded to stimuli applied to the skin. The majority were located in the middle cortical layers. Each of the cells subjected to tests with glutamate and acetylcholine (ACh) was rapidly adapting to cutaneous stimuli, giving a response at the onset of skin indentation and sometimes after the stimulus withdrawal. 2. Of the 30 cells tested by pairing basal forebrain (BF) stimulation with cutaneous stimulation. 18 (60%) displayed enhanced responses to the same cutaneous stimulus after the pairing. These effects lasted for greater than 5 min in 17 cases, persisting for as long as the cell was studied, sometimes greater than 1 h. 3. The enhanced responsiveness to cutaneous stimuli could not be reversed by atropine, but in each of the 11 cells where atropine was administered while the BF stimulus was paired with the skin stimulus, the pairing produced no enhancement. 4. We conclude that pairing a BF stimulus with a cutaneous stimulus leads to long-term facilitation of the responsiveness of the cortical neuron subjected to this treatment and that this effect is mediated by the release of acetylcholine from BF cholinergic neurons that act on muscarinic receptors found on neurons in the somatosensory cortex.
TouchMover 2.0 - 3D touchscreen with force feedback and haptic texture (2014)

This paper presents the design and development of a novel visio-haptic device that co-locates 3D stereo visualization, direct touch, texture and touch force sensing with a robotically actuated display. Our actuated immersive 3D display, called TouchMover 2.0, is capable of providing 1D movement (up to 36cm), haptic screen force feedback (up to 230N) in a single dimension perpendicular to the screen plane, and has an additional capability to render haptic texture cues via vibrotactile actuators attached to the touchscreen. We describe the details of our design and improvements. We showcase how TouchMover 2.0 allows the user to: touch and feel the 3D contour and 2D texture of a topographic map, to interact with 3D objects by pushing them on the screen with realistic force feedback and intuitively explore and feel pseudo tissue texture within volumetric data from medical imagery (e.g., MRI brain scan).
Analysis of the attenuation ratio of MQW optical intensity modulator for 1.55 μm wavelength taking account of electron wave function leakage (1996)

A theoretical analysis of an attenuation ratio for MQW optical intensity modulator was carried out taking account of the leakage of electron envelope function from the well layer. In the MQW modulator using InGaAsP material, the leakage of electron envelope function is large even for a low applied field because of the comparatively low potential barrier for electron. A normalization scheme in energy space was introduced for such leaky envelope function and field dependence of the Stark shift and oscillator strength have been analyzed by solving exciton effective mass equation. This approach was applied to MQW modulator for the wavelength of 1.55 /spl mu/m for optical communication system. The well width and well number for large attenuation ratio with small residual absorption have been obtained. The calculation was compared with the experimental result and the difference was discussed.
Small Molecule BMH-Compounds That Inhibit RNA Polymerase I and Cause Nucleolar Stress (2014)

Activation of the p53 pathway has been considered a therapeutic strategy to target cancers. We have previously identified several p53-activating small molecules in a cell-based screen. Two of the compounds activated p53 by causing DNA damage, but this modality was absent in the other four. We recently showed that one of these, BMH-21, inhibits RNA polymerase I (Pol I) transcription, causes the degradation of Pol I catalytic subunit RPA194, and has potent anticancer activity. We show here that three remaining compounds in this screen, BMH-9, BMH-22, and BMH-23, cause reorganization of nucleolar marker proteins consistent with segregation of the nucleolus, a hallmark of Pol I transcription stress. Further, the compounds destabilize RPA194 in a proteasome-dependent manner and inhibit nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-9- and BMH-22-mediated nucleolar stress was detected in ex vivo-cultured human prostate tissues indicating good tissue bioactivity. Testing of closely related analogues showed that their activities were chemically constrained. Viability screen for BMH-9, BMH-22, and BMH-23 in the NCI60 cancer cell lines showed potent anticancer activity across many tumor types. Finally, we show that the Pol I transcription stress by BMH-9, BMH-22, and BMH-23 is independent of p53 function. These results highlight the dominant impact of Pol I transcription stress on p53 pathway activation and bring forward chemically novel lead molecules for Pol I inhibition, and, potentially, cancer targeting.
Risk of breast cancer in women with history of benign disease of the breast. (1984)

A consecutive series of 791 women who had attended diagnostic breast clinics during 1967-70 and been found to be free of malignant disease were later traced to determine their subsequent incidence of breast cancer. Of the 770 (97%) successfully traced, 22 had developed breast cancer. Based on data from the Welsh Cancer Registry only eight cases of breast cancer had been expected, so that the excess risk for the group was 2.7. The increased risk occurred in all age groups and in women deemed "essentially normal" as well as in those who had had a pathological abnormality. The risk was increased when epithelial hyperplasia was present. No excess mortality from breast cancer was apparent, but follow up was short. More breast symptoms were experienced and more biopsies performed than expected in this group of women. Women with a past history of benign breast disease have a slightly increased risk of breast cancer. Selective screening of these women, however, may be uneconomic and a cause of groundless anxiety.
Chromatic interferometry for an intelligent plasma processing system (1994)

A thin film measuring system for the online monitoring of semiconductor films during processing with a radio frequency plasma is described. The method is based upon the use of chromatic processing of polychromatic interference signals produced by the thin semiconductor film when illuminated with white light. A description is given of the interpretation of the polychromatic signals produced by interference effects and some typical experimental results are presented to illustrate the capabilities of the technique. The approach utilizes cost effective instrumentation with acceptable time response for real time process control via optical fibre transmission. It is currently being incorporated as part of an intelligent knowledge based system for such process control.
p53-Independent Endoplasmic Reticulum Stress-Mediated Cytotoxicity of a Newcastle Disease Virus Strain in Tumor Cell Lines (2007)

While Newcastle disease virus (NDV) causes serious infections in birds, it is apparently nonpathogenic in mammalian species, including humans. Previous observations and small-scale clinical trials indicated that NDV exerts oncolytic effects. Isolates of NDV were found to have selective affinity to transformed cells. We previously showed that the attenuated NDV strain MTH-68/H causes apoptotic cell death in cultures of PC12 rat pheochromocytoma cells. The aim of the present study was to extend MTH-68/H cytotoxicity testing with human tumor cell lines and to analyze certain biochemical aspects of its oncolytic effect. MTH-68/H was found to be able to kill a wide range of transformed cells by apoptosis. While caspase-8 and caspase-9 are not involved in MTH-68/H-induced apoptosis, activation of caspase-3 and caspase-12 was detected in virus-infected PC12 cells. A human glioblastoma cell line with repressible expression of the p53 protein did not show any difference in MTH-68/H sensitivity in its p53-expressing and p53-depleted states, indicating that the apoptotic process induced by MTH-68/H does not depend on p53. Apoptosis was accompanied by virus replication in two tumor cell lines tested (PC12 cells and HeLa human cervical cells), and signs of endoplasmic reticulum stress (phosphorylation of protein kinase R-like endoplasmic reticulum kinase and eIF2alpha) were also detected in transformed cells. In contrast, proliferation of nontransformed mouse and rat fibroblast cell lines and human primary fibroblasts was not affected by MTH-68/H treatment. MTH-68/H thus selectively kills tumor cell cultures by inducing endoplasmic reticulum stress leading to p53-independent apoptotic cell death.
ChemInform Abstract: Broensted Acid Catalyzed Asymmetric Reduction of Ketones and Acyl Silanes Using Chiral anti‐Pentane‐2,4‐diol. (2010)

Abstract The metal‐free asymmetric reduction of ketones that uses the chiral diol (II) under Broensted acid catalysis is reported.
In vitro activities of rifapentine and rifampin, alone and in combination with six other antibiotics, against methicillin-susceptible and methicillin-resistant staphylococci of different species (1985)

The antistaphylococcal activity of rifapentine, a new rifamycin SV derivative, was evaluated in vitro and compared with that of rifampin. A total of 313 staphylococcal strains freshly isolated from clinical material and including representatives of all currently recognized Staphylococcus species of human origin were used. The susceptibility to methicillin of all the test strains was determined preliminarily. Despite minor differences with some species, the MICs of rifapentine were found to be substantially similar to those of rifampin. Methicillin-resistant strains of all species were most resistant to rifapentine and rifampin than were their methicillin-susceptible counterparts. For most strains tested, the MBCs of both rifamycins exceeded by twofold the respective MICs. Both the checkerboard dilution and time-kill methods were used to determine the interactions of rifapentine or rifampin with six different antibiotics: cefamandole, vancomycin, teicoplanin, gentamicin, erythromycin, and fusidic acid. No significant differences between the two rifamycins in the combinations were observed against either methicillin-susceptible or methicillin-resistant strains. Minor differences were noted depending on the second antibiotic tested or the staphylococcal species examined. Antagonism was never observed, and indifference was the prevalent response. Cases of synergism were observed occasionally with the checkerboard method and slightly more often with the time-kill method.
Digital Transmitter I/Q Imbalance Calibration: Real-Time Prototype Implementation And Performance Measurement (2010)

Publication in the conference proceedings of EUSIPCO, Aalborg, Denmark, 2010