gebhart/patrepeval huggingface dataset:
MeCP2: structure and functionThis paper is one of a selection of papers published in a Special Issue entitled 31st Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process. (2011)

Despite a vast body of literature linking chromatin structure to regulation of gene expression, the role of architectural proteins in higher order chromatin transitions required for transcription activation and repression has remained an under-studied field. To demonstrate the current knowledge of the role of such proteins, we have focused our attention on the methylated DNA binding and chromatin-associated protein MeCP2. Structural studies using chromatin assembled in vitro have revealed that MeCP2 can associate with nucleosomes in an N-terminus dependent manner and efficiently condense nucleosome arrays. The present review attempts to match MeCP2 structural domains, or lack thereof, and specific chromatin features needed for the proper recruitment of MeCP2 to its multiple functions as either activator or repressor. We specifically focused on MeCP2's role in Rett syndrome, a neurological disorder associated with specific MeCP2 mutations.
Species-specific detection of Legionella pneumophila in water by DNA amplification and hybridization (1989)

A sensitive detection system specific for Legionella pneumophila in water was developed. This system is based on amplification of a chromosomal DNA sequence from L. pneumophila by the polymerase chain reaction, followed by detection of the amplified product by hybridization of a radiolabeled oligodeoxynucleotide. After 35 cycles of amplification, a water sample which had been seeded with 35 CFU of L. pneumophila contained sufficient amplified DNA to be detected on dot blots. Bacteria of other genera tested did not generate positive signals under these conditions. Application of this technique to environmental water samples may help identify the natural reservoirs of nosocomial and community-acquired L. pneumophila infections.
Closed-loop phase-shifting interferometry with a laser diode (1998)

A closed-loop phase-shifting Fizeau-type interferometer at ?=633 nm was constructed with the direct frequency modulation of laser diodes. The interferometer is servo controlled fully in the phase domain where optical phases are detected by a two-frequency optical heterodyne method. Stepwise phase shifting was accomplished with good stabilization against external disturbances (vibration, air flow, etc.)??and laser frequency fluctuations.
Myocardial damage delineated by indium-111 antimyosin Fab and technetium-99m pyrophosphate. (1987)

Technetium-99m-labeled pyrophosphate and radiolabeled antimyosin antibodies are two infarct localizing agents with apparently different kinetics of localization. To determine whether these agents localize in a similar fashion in early acute myocardial necrosis, we studied the simultaneous distribution of 111In-labeled antimyosin and 99mTc-labeled pyrophosphate in dogs after intracoronary (i.c.) (n = 9) or intravenous (i.v.) (n = 9) administration of a mixture of these two agents in a reperfused infarct model. The mean infarct size (+/- s.d.) delineated by pyrophosphate [20.2 +/- 14.1 (i.v.), 29.8 +/- 12.3 (i.c.)] was larger than that by antimyosin [14.2 +/- 11.3 (i.v.) (p = 0.05), 20.0 +/- 11.8 (i.c.) (p = 0.05)] which was larger than that by triphenyl tetrazolium chloride [13.9 +/- 8.0 (i.v.) (p = 0.05), 15.3 +/- 6.5 (i.c.) (p = 0.05)]. This overestimation persisted whether the radiopharmaceuticals were administered by intracoronary or intravenous injections, although the latter with antimyosin was only slightly larger (TTC:AM = 13.9:14.2) (p = n.s.). There was a good correlation, however, between antimyosin and pyrophosphate delineated infarct sizes in dogs with intracoronary injection (y = 0.82x + 13.33, r = 0.79) or i.v. injection (y = 1.208x + 3.01, r = 0.97) of the mixture of the two agents. Since the images of the 111In and 99mTc activities were obtained consecutively by identical methods, the overestimation of infarct size by pyrophosphate cannot be due to differences in spatial resolution of the techniques used. The differences in the areas of myocardial damage delineated by pyrophosphate and antimyosin in our study most probably denote the area of viable but compromised myocardium.
Optimum Design of Water Jet Pumps (1969)

A summary of an extensive program of experimental and analytical work leading to a procedure for obtaining optimized performance of water jet-pump systems is presented. The procedure is extended to include systems involving n, series-staged ejector components operating in an optimal manner as a complete pump, pipeline, ejector unit. The theoretical, limiting performance of ejectors is established and several examples involving different design situations are shown.
Steering Stability Control of a Four In-Wheel Motor Drive Electric Vehicle on a Road With Varying Adhesion Coefficient (2019)

In order to improve the steering stability of a four in-wheel motor independent-drive electric vehicles (4MIDEVs) on a road with varying adhesion coefficient, such as on a joint road and a μ-split road, this paper presents a hierarchical electronic steering control (ESC) strategy. The upper level controller of the proposed ESC strategy achieves the adaptive control of the yaw rate and sideslip angle in the direct yaw-moment control based on the influence of road adhesion. The lower level controller is designed as a two-hierarchy structure, which can adaptively change the torque allocation algorithm and achieve different weight controls of each wheel torque according to road adhesion coefficient. The results of real-time simulation conducted in the RT-LAB testing platform and a real-car test indicate an improvement in the steering stability of the 4MIDEV on a road with varying adhesion coefficient. Particularly the “double lane change”testing carried out on a joint road and a μ-split road shows a yaw rate error reduction of up to 55.1%, compared with the ordinary control strategy, with output torque and its fluctuation of each in-wheel motor significantly reduced.
Comparison of Activated Carbon and Zeolite 13X for CO2 Recovery from Flue Gas by Pressure Swing Adsorption (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of Activated Carbon and Zeolite 13X for CO2 Recovery from Flue Gas by Pressure Swing AdsorptionK. T. Chue, J. N. Kim, Y. J. Yoo, S. H. Cho, and R. T. YangCite this: Ind. Eng. Chem. Res. 1995, 34, 2, 591–598Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/ie00041a020https://doi.org/10.1021/ie00041a020research-articleACS PublicationsRequest reuse permissionsArticle Views7723Altmetric-Citations422LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Laser generation of ultra high pressure (1986)

The generation of ultra high pressure by laser beams is reviewed in the context of laser driven inertial confinement fusion. Central pressures of 200 GBar are required in an imploded pellet and are achieved by the amplification of the laser generated pressure in the implosion. The theory of laser driven ablation predicts greater efficiency with shorter laser wavelength but with the penalty of greater susceptibility to laser beam non-uniformity. A variety of experimental measurements of laser ablation is described and their results are in good agreement with applicable theories. Factors determining the overall implosion symmetry and pressure multiplication are discussed briefly.
MUTUALITY FOR FOOTBALL CLUBS? LESSONS FROM THE FINANCIAL SECTOR (2004)

The mutualisation of two English third division football clubs in 2001 and the creation of a large number of supporters' trusts make it timely to consider whether there is a case for mutualisation of football clubs. This paper assesses whether mutuality would be of economic benefit for clubs, drawing heavily on the experience of mutuals in the financial sector. Our conclusions are mixed. The economic case rests on the distinctive feature of customer loyalty to a club, presuming this to be much stronger than loyalty to a financial institution. However, club members in a mutual must expect to be called upon to provide financial support.
The Evolution of Price Dispersion in the European Car Market (2001)

Car prices in Europe are characterized by large and persistent differences across countries. The purpose of this paper is to document and explain this price dispersion. Using a panel data set extending from 1980 to 1993, we first demonstrate two main facts concerning car prices in Europe: (1) The existence of significant differences in quality adjusted prices across countries, with Italy and the U.K. systematically representing the most expensive markets. (2) Substantial year-to-year volatility that is to a large extent accounted for by exchange rate fluctuations and the incomplete response of local currency prices to these fluctuations. These facts are analysed within the framework of a multiproduct oligopoly model with product differentiation. The model identifies three potential sources for the international price differences: price elasticities generating differences in markups, costs, and import quota constraints. Local currency price stability can be attributed either to the presence of a local component in marginal costs, or to markup adjustment that is correlated with exchange rate volatility; the latter requires that the perceived elasticity of demand is increasing in price. We find that the primary reason for the higher prices in Italy is the existence of a strong bias for domestic brancs that generates high markups for the domestic firm (Fiat). In the U.K. higher prices are mainly attributed to better equipped cars and/or differences in the dealer discount practices. The import quota constraints are found to have a significant impact on Japanese car prices in Italy, France and the U.K. With respect to local currency price stability, a large percentage of the documented price inertia can be attributed to local costs, and a smaller fraction to markup adjustment that is indicative of price discrimination. Based on these results we conjecture that the EMU will substantially reduce the year-to-year volatility observed in the car price data, but without further measures to increase European integration, it will not completely eliminate existing cross-country price differences.
A dual band FMCW radar receiver with integrated active balun and baseband AGC loop (2017)

This work presents the design of a dual band frequency modulated continuous wave (FMCW) radar receiver (RX) at the 2.4 and 5.8 GHz industrial, scientific and medical (ISM) bands. The designed low noise amplifier (LNA) has a single ended 50 Ω input stage followed by an active balanced-to-unbalanced (balun) stage. The radio frequency (RF) signal is then down-converted to a low intermediate frequency (IF) by a multi-tanh Gilbert cell mixer whose local oscillator (LO) port is driven by an integrated fractional-N phase locked loop (Frac-N PLL). After down-conversion, the resulting IF signal is low pass filtered and amplified by a baseband variable gain amplifier (VGA). Fabricated on an IBM 0.18 μm BiCMOS process, the measured RX performance is in good agreement with simulations achieving a measured maximum conversion gain (CG) of 82.0 and 77.2 dB and a noise figure (NF) of 7.3 and 8.0 dB at the 2.4 and 5.8 GHz bands respectively. The receiver consumes 22.3 mA from a 3 V supply and occupies a chip area of 0.32 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . When used as a primary FMCW radar transceiver (TRX), the designed chip achieves a ranging precision of 0.30 and 0.31 mm at the 2.4 and 5.8 GHz bands respectively. To the best of the author's knowledge, this dual band FMCW radar TRX has the highest level of integration reported in the literature.
Hepatocyte Asialoglycoprotein Receptor Assay Using Stable Isotopes and Neutron Activation Analysis (2000)

Since the initial studies of receptor-mediated endocytosis on LDL (1)(2) and asialoglycoprotein (ASGP) (3)(4), many internalized ligands and their receptors have been identified and characterized (5). It was soon recognized that these receptors could be exploited for pharmaceutical and medical imaging applications (6). In the case of the ASGP receptor (ASGP-R), delivery of diagnostic or therapeutic agents to hepatocytes was achieved by attachment of the agent to a variety of macromolecules possessing the terminal galactose signal necessary to bind the ASGP-R (6). These moieties include radioactive isotopes (7), drugs (8), and DNA (9).

Considering the effort devoted to developing drug delivery systems utilizing the ASGP-R, surprisingly little effort has been devoted to developing simple, easy-to-use assays to measure this receptor activity in vivo. Much of the technology associated with receptor-based diagnostic agents has arisen in fields associated with magnetic resonance and single photon emission computed tomography imaging. One class of magnetic resonance compounds includes iron chelates, which appear to be absorbed by hepatocytes by an unknown biochemical mechanism (10). Saini et al. (11) and others have demonstrated the promise of ferrite particles as a magnetic resonance contrast agent for liver imaging. These commercially available micron-sized particles are taken up by the Kupffer cells of liver and do not measure ASGP-R activity.

Sato et al. (12) reported on the ability of the ASGP-R to take up galactose-terminated, protein-coated ferrite particles in vivo. These particles are taken up preferentially by hepatocytes (70%) and largely avoid uptake by the reticular endothelial system. For a crystal-based material to bind the ASGP-R of hepatocytes, it must penetrate pores of the 100-nm fenestrae characteristic of endothelial cells that lie between the hepatocyte and the circulatory compartment (13). Particles smaller than 100 nm are needed to serve as hepatocyte-directed diagnostic agents.

Josephson …
The Progression of Liver Fibrosis Is Related with Overexpression of the miR-199 and 200 Families (2011)

Four miRNAs are tightly related to the grade of liver fibrosis in both human and mouse was shown. This information may uncover the critical mechanism of progression of liver fibrosis. miRNA expression profiling has potential for diagnostic and therapeutic applications.
Preparation of α-cyanoacrylate from Methylacrylate (1969)

Methyl acrylate is cony erted quantitatively to methyl α, β-dichloropropionate by chlorination at room temperature in the presence of 4 mol-% DMF as the catalyst.Methyl α, β-dichloropropionate is then methoxylated by reaction with an equimolar amount of Na-methylate in one hour without a catalyst at -20 to -35°C in mately 90% yield.Methyl α-chloro-β-methoxypropionate is let to react with an equimolar amount of potassiumcyanide at 30°C in a homogeneous solution. The yield is about 95%, but part of the produced α-cyano-β-methoxy propionate changes into poly-α-cyanoacrylate. Therefore, the true cyanation yield appears to be between 60 to 70%.Then crude methyl α-cyano-β-methoxypropionate is converted to methyl α-cyanoacrylate at rather high temperature, since the reaction involves the degradation of poly-α-cyanoacrylate. The reaction is carried out at 170250°C/39mmHg in a SO2 stream in the presence of 3 mole-% sulfuric acid and 100 g of DOP. Approximately 80% yield is attained.
Transfer of a Speed of Processing Intervention to Near and Far Cognitive Functions (2002)

Speed of processing training may enhance the speed at which older adults can perform instrumental activities of daily living.
Analysis, Evaluation and Development of Wheelchair-Mounted Robotic Arms (2005)

This paper focuses on kinematic analysis and evaluation of wheelchair mounted robotic arms (WMRA). It addresses the kinematics of the WMRA with respect to its ability to reach common positions while performing activities of daily living (ADL). A procedure is developed for the kinematic analysis and evaluation of a WMRA. In an effort to evaluate two commercial WMRAs, the procedure for kinematic analysis is applied to each manipulator. Design recommendations and insights with regard to each device are obtained and used to design a new WMRA to overcome the limitations of these devices. This method benefits the researchers by providing a standardized procedure for kinematic analysis of WMRAs that is capable of evaluating independent designs.
Arguments for an increasing differentiation towards fibrocartilaginous components in midportion Achilles tendinopathy (2012)

Immunohistochemical staining of the fibrocartilaginous components biglycan and aggrecan showed a progressive increase, correlated with a further evolved histopathological stage. This observation gave arguments for an increased differentiation towards fibrocartilaginous components at protein level in midportion Achilles tendinopathy.
DECOMPOSITION IN SOIL Fate of 2-chloro-s-triazine herbicides in soil (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDECOMPOSITION IN SOIL Fate of 2-chloro-s-triazine herbicides in soilClare Irving. HarrisCite this: J. Agric. Food Chem. 1967, 15, 1, 157–162Publication Date (Print):January 1, 1967Publication History Published online1 May 2002Published inissue 1 January 1967https://pubs.acs.org/doi/10.1021/jf60149a030https://doi.org/10.1021/jf60149a030research-articleACS PublicationsRequest reuse permissionsArticle Views109Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Line shapes and half widths of pure- and foreign-gas-broadened 2.5-μm HF absorption spectra (1979)

The absorption line shapes of the ${R}_{1}(1)\ensuremath{-}{R}_{1}(5)$ lines of HF have been measured as a function of pressure for pure HF and with Ar and Kr as buffer gases by means of a cw tunable ${F}_{B}$ (II)-type color-center laser operating in the wavelength range from 2.25 to 2.65 \ensuremath{\mu}m. Line-broadening coefficients are determined and Einstein $A$ coefficients are evaluated from the line shapes. Collisional narrowing is observed for the ${R}_{1}(4)$ line with Kr as the buffer gas.
Receptivity of Human Choriocarcinoma JEGIII Cells and Isolated Trophoblast Cells to Hepatitis B Virus Infection and Enhancement by Tumor Necrosis Factor Alpha (2007)

Intrauterine infection of the fetus is clearly an important mode of vertical transmission of hepatitis B virus (HBV). The trophoblast layer of the human placenta must be traversed by HBV in order to reach underlying cells and fetal capillaries. Although HBV has been detected in the trophoblast layer in situ, the degree of susceptibility of primary trophoblast cells to direct HBV infection in vitro remains unknown. To determine the receptivity of trophoblast cells to HBV infection and to discover the cellular basis for the molecular mechanism responsible for the passage of HBV from the maternal to the fetal circulation, we infected choriocarcinoma JEGIII cells and primary trophoblast cells with HBV. Our findings suggest that the cells could be reproducibly infected with HBV and that the infective patterns of the isolated trophoblasts and JEGIII cells were remarkably similar. In vitro infection resulted in an intracellular viral DNA and hepatitis B surface antigen signal and the secretion of hepatitis B surface antigen into culture medium. The results suggest that both isolated trophoblast cells and trophoblast-derived choriocarcinoma cells are sensitive to infection with HBV in vitro. In addition, we have found that infection of trophoblast cells and JEGIII cells by HBV was enhanced in the presence of tumor necrosis factor alpha. This supports an additional role for tumor necrosis factor alpha in the entry of HBV into trophoblast cells during pregnancy.
Syntheses of Heterocyclic Compounds of Nitrogen. CX. Azaphenoxazine Derivatives. (1958)

3-Bromo-4-(o-hydroxyphenylamino)-5-nitropyridine prepared from the potassium salt of o-aminophenol and 3-bromo-4-chloro-5-nitropyridine easily yielded 4-nitro-5H-benzo [b] pyrido [4, 3-e]-1, 4-oxazine by the intramolecular condensation in the presence of piperidine or potassium hydroxide. Attempts to prepare a ring-fused azaphenoxazine from the potassium salts of o-aminophenol and 2-chloro-3, 5-dinitropyridine in alkaline medium ended in failure, only giving 2-(o-hydroxyphenylamino)-3, 5-dinitropyridine. On the other hand, when 2-chloro-3, 5-dinitropyridine was allowed to react with o-methylaminophenol, 3-nitro-10-methylbenzo [e] pyrido [3, 2-b]-1, 4-oxazine was obtained. These facts are well explainable from the hypothesis of a chelate ring formation forwarded by Brady. 3-Amino-5-chloro-2-pyridone was condensed with s-trinitroanisole giving 3-chloro-6, 8-dinitro-5H-benzo [b] pyrido [3, 2-e]-1, 4-oxazine.