gebhart/patrepeval huggingface dataset:
High-frequency Haplotypes in the X Chromosome Locus TLR8 Are Associated With Both CD and UC in Females (2008)

TLR8 is an X-linked IBD susceptibility gene with both common predisposing and protecting haplotypes. These associations further emphasize the importance of genetic variation in innate immunity as determinants, not only of CD, but of UC as well.
A Leakage-Based Random Bit Generator with On-line Fault Detection (2006)

This paper presents a new, patent pending, random bit generator whose noise source exploits the leakage current in a reverse biased p-n junction. The circuit is described and a model is provided to estimate data-rate and expected quality of the generated bit sequence. Since the noise source is quasi-stateless, its deterministic evolution does not present complex patterns and therefore a lack of entropy and faults can be detected on-line
Bioelectric controls of cell proliferation: Ion channels, membrane voltage and the cell cycle (2009)

All cells possess long-term, steady-state voltage gradients across the plasma membrane. These transmembrane potentials arise from the combined activity of numerous ion channels, pumps and gap junction complexes. Increasing data from molecular physiology now reveal that the role of changes in membrane voltage controls, and is in turn controlled by, progression through the cell cycle. We review recent functional data on the regulation of mitosis by bioelectric signals, and the function of membrane voltage and specific potassium, sodium and chloride ion channels in the proliferation of embryonic, somatic and neoplastic cells. Its unique properties place this powerful, well-conserved, but still poorly-understood signaling system at the center of the coordinated cellular interactions required for complex pattern formation. Moreover, disregulation of ion channel expression and function is increasingly observed to be not only a useful marker but likely a functional element in oncogenesis. New advances in genomics and the development of in vivo biophysical techniques suggest exciting opportunities for molecular medicine, bioengineering and regenerative approaches to human health.
The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells. (2006)

Since the identification of the p38 mitogen-activated protein kinase (MAPK) as a key signal-transducing molecule in the expression of the proinflammatory cytokine tumor necrosis factor (TNF) more than 10 years ago, huge efforts have been made to develop inhibitors of p38 MAPK with the intent to modulate unwanted TNF activity in diseases such as autoimmune diseases or sepsis. However, despite some anti-inflammatory effects in animal models, no p38 MAPK inhibitor has yet demonstrated clinical efficacy in human autoimmune disorders. One possible reason for this paradox might relate to the fact that the p38 MAPK signaling cascade is involved in the functional regulation of several different cell types that all contribute to the complex pathogenesis of human autoimmune diseases. In particular, p38 MAPK has a multifaceted role in CD4 T cells that have been implicated in initiating and driving sustained inflammation in autoimmune diseases, such as rheumatoid arthritis or systemic vasculitis. Here we review recent advances in the understanding of the role of the p38 MAPK signaling cascade in CD4 T cells and the consequences that its inhibition provokes in T cell functions in vitro and in vivo. These new data suggest that p38 MAPK inhibitors may elicit several unwanted effects in human autoimmune diseases but may be useful for the treatment of allergic disorders.
The chemistry of peroxonitrites. Part II. Copper(II)-catalysed reaction between hydroxylamine and peroxonitrite in alkali (1970)

Hydroxylamine and peroxonitrite react in alkaline solution in the absence of oxygen, in a metal-ion catalysed reaction, giving nitrite and nitrous oxide. It is suggested that the nitrous oxide is formed by the decomposition of cis-hyponitrite, which, in turn, is produced by the dimerisation of nitroxyl, NO–, one of the initial products of the reaction. Evidence is presented to show the presence of NO– as an intermediate and the instability of cis-hyponitrite under the conditions of the reaction. A little trans-hyponitrite is probably formed in this reaction, presumably also by NO– dimerisation. In the presence of oxygen, the stoicheiometry is changed, hydroxylamine being oxidised to nitrite with apparently no loss of peroxonitrite. It is suggested that this is due to the reformation of peroxonitrite by the addition of oxygen to NO–. The stability of Angeli's salt has been re-investigated while we have been unable to prepare sodium β-oxohyponitrite by the N2O4 oxidation of hyponitrite. Both these were considered as intermediates.
Fast screening of paramagnetic molecules in zebrafish embryos by MRI (2007)

Zebrafish embryo is a well-established model used in many fields of modern experimental biology. We demonstrate that it provides a promising model platform for exploring fundamental MR aspects that can be used to screen and study active MR molecules before progressing to more complex living systems. Setting up a dedicated MRI methodology, we arrayed a large number of living embryos, which were microinjected at very early stages of development with different contrast agents. We also showed that MRI signal intensity correlates with the gadolinium content of zebrafish embryos. This allowed us to validate a new approach for MR compound screening. Using a specific surface coil of 5 mm inner diameter, we obtained for the first time high-spatial-resolution images at 7 T of living zebrafish embryos with a 47 microm isotropic voxel size with an acquisition time of 39 min. Finally, we discuss potential applications of this development: a viable in vivo assay for screening small pharmacological compounds; assessment of and tracking the action of molecules over time. Exploring in vivo biological activity, gene function analysis, and detailed characterization of disease processes in fish are natural extensions of these preliminary studies.
Psychometric Normalization of a Hyperacusis Questionnaire (2002)

Clinical hyperacusis consists of a marked intolerance to ordinary environmental sounds, while hearing thresholds are quite often normal. Hyperacusis appears to be a subjective phenomenon, which is not easily defined or quantified by objective measurements. In order to create a tool suitable to quantify and evaluate various hyperacusis symptoms, a questionnaire screening several aspects of auditory symptomatology has been constructed. Two hundred and one subjects (who were either hyperacusic or not), randomly selected from the general population, were tested. A principal component analysis performed on the correlation matrix of the 14 items of the questionnaire isolated three dimensions: attentional, social, and emotional. The three dimensions had satisfactory internal consistency reliability. The mean +/- SD total score was 15 +/- 6.7 out of 42 (maximum of hyperacusis) and a score greater than 28 seems to represent a strong auditory hypersensitivity. This new psychometric tool should further be tested on hyperacusic patients to verify its relevance in pathology and define the involvement of the three dimensions statistically obtained on the hyperacusis symptomatology.
Conceptual Design of CO2 Transportation System for CCS (2013)

Reducing carbon dioxide (CO2) emission is strongly requested in relation to the global warming issue. The development of innovative technology including Carbon dioxide Capture and Storage (CCS) is required to achieve the CO2 reduction targets. Because of the geological structure of the domestic complex in Japan, reservoirs near sources of emissions have not enough storage capacity of CO2. Therefore, transportation to suitable sites will be necessary for large amount of CO2 storage. Three methods of transporting CO2 from coal-fired power plant to offshor storage sites near japan1's coastline were studied. One with transporting liquefied CO2 by ship, another with transporting CO2 hydrate by ship, and the third by a pipeline. Transportation distance is approximately 700–1,000 km for the former two cases, and 120 km for pipeline. The case study on a demonstration scale and a commercial use was executed. The CO2 transport volume set for each case is 240,000 ton-CO2/year and 1,540,000 ton- CO2/year respectively. This research was executed as a contract study from New Energy and Industrial Technology Development Organization (NEDO).
Semiempirical Use of Chirality Functions for the Description of the Optical Activity of Allene Derivatives in the Transparent Region (1973)

Abstract A comparison of calculated and experimental data shows that the optical rotatory power of phenylallenecarboxylic acids is quantitatively described by the polynomial expression developed in (1). The T d component of this expression, the only relevant one for the case of methane derivatives turns out to be negligibly small in the case of allene derivatives. Therefore, and because allene derivatives belong to category a [16] the sequence of the λ‐parameter values of the ligands may be used to determine the configuration and the sign of rotation.
MIND+ system; More universal dose patterns by single-step ion implantation (2012)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Yasuharu Okamoto, Shiro Ninomiya, Akihiro Ochi, Yusuke Ueno, Tatsuya Yamada, Yasuhiko Kimura, Tetsuya Kudo, Masazumi Koike, Noriyuki Suetsugu, Yoshiaki Ookita, Mitsukuni Tsukihara, Fumiaki Sato, Genshu Fuse, Kazuyoshi Ueno, Michiro Sugitani; MIND+ system; More universal dose patterns by single-step ion implantation. AIP Conference Proceedings 6 November 2012; 1496 (1): 348–351. https://doi.org/10.1063/1.4766560 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
A new string search hardware architecture for VLSI (1986)

This paper presents a new architecture for practical string search hardware design. This architecture is based on the finite state automaton design concept using a character control charge transfer model. The resultant hardware is a set of programmable sequential logic (PSL) circuits, each of which consists of a sequential logic and memory parts. The logic part is an array of logical gates, each of which is controlled by the read-out signal from the memory part, to connect the flip-flops. The memory part stores each variable-length pattern string character on a bit line by bit line basis. Then, several pattern strings in the memory part can be compared with the serial input data string in parallel, even at a non-anchor mode and an approximate matching mode. This new hardware can be easily implemented in an LSI chip, which allows 8192 pattern string storage using 1 Mb RAM cells.
Atlas of the Arteries of the Human Brain. (1972)

This new volume from the professor of neuroradiology at Marseilles is a triumph of the bookmakers art and a pleasure on that basis alone. The atlas consists principally of a series of photographs of brain sections cut in the frontal, horizontal, and sagittal planes; each photograph being accompanied by a transparent reproduction of the postmortem arteriogram of the particular cerebral section concerned. Superimposition of the relevant angiographic transparencies over the photograph of the brain enables the reader to visualize the arterial systems of the cortex, white matter, and basal nuclei in three dimensions. The atlas also contains a radiographic study of the anatomy of the major individual arteries to the brain, and concludes with a microangiographic study of certain vascular areas. The index is arranged so that both the sections illustrating the individual arteries and those illustrating the structures they supply can readily be found. The index is actually presented
Spontaneous emission in the waveguide free-electron laser (1985)

The incoherent emission from an undulating electron beam in the presence of metallic boundaries is analyzed. A general method of solving Maxwell's equations is used to express the field of a single particle in terms of vector waveguide modes. It is shown that the radiation characteristics depend upon a parameter involving the energy, wiggler wavelength, and the waveguide transverse dimension. At some values of this parameter the energy spectrum and angular distribution will differ significantly from the analogous free-space results. The amount of energy emitted into resonator modes is also analyzed in terms of a similar expansion.
Luminescent Core–Shell Imprinted Nanoparticles Engineered for Targeted Förster Resonance Energy Transfer-Based Sensing (2013)

Red-luminescent 200 nm silica nanoparticles have been designed and prepared as a versatile platform for developing FRET (Förster resonance energy transfer) biomimetic assays. Ru(phen)₃²⁺ dye molecules embedded off-center in the silica core provide the long-lived donor emission, and a near-infrared labeled analyte serves as fluorescent acceptor (the measured R₀ of this D-A pair is 4.3 nm). A thin surface-grafted molecularly imprinted polymer (MIP) shell intervenes as selective enrofloxacin-binding element. These nanoparticles have been tested for photochemical detection of enrofloxacin by using a competitive scheme that can be readily performed in MeCN-HEPES (pH 7.5) 7:3 (v/v) mixtures and allows for the antibiotic detection in the μM range (LOD = 2 μM) without optimization of the assay. Given the well-known difficulties of coupling the target-binding-to-MIP and the transducing events, the novel photochemical approach tuned up here will be valuable in future developments of MIP-based assays and optosensors that capitalize also on the advantages of nanomaterials for (bio)analysis.
Stream derivation and clustering scheme for subspace distribution clustering hidden Markov model (2002)

Bocchieri and Mak (Proc. Eurospeech, vol. 1, p. 107-10, 1997) introduced a novel subspace distribution clustering hidden Markov model (SDCHMM) as an approximation to a continuous-density HMM (CDHMM). Deriving SDCHMMs from CDHMMs requires a definition of multiple streams and a Gaussian clustering scheme. Previously, we have tried 4 and 13 streams, which are common but ad hoc choices. In this paper, we present a simple and coherent definition for streams of any dimension: the streams comprise the most correlated features. The new definition is shown to give better performance in two speech recognition tasks. The clustering scheme of Bocchieri and Mak is an O(n/sup 2/) algorithm which can be slow when the number of Gaussians in the original CDHMMs is large. Now, we have devised a modified k-means clustering scheme using the Bhattacharyya distance as the distance measure between Gaussian clusters. Not only is the new clustering scheme faster but, when combined with the new stream definitions, we now obtain SDCHMMs which perform at least as well as the original CDHMMs (with better results in some cases).
The ABCs of IGF-I isoforms: impact on muscle hypertrophy and implications for repair (2006)

Insulin-like growth factor I (IGF-I) plays a critical role in the growth and development of many tissues in the body. It is a key regulator of skeletal muscle development, and continues to enhance the ability for muscle to grow and undergo repair throughout life. Although the focus of research has been on the molecular actions and physiological impact of IGF-I, there has also been a growing undercurrent of studies geared toward the characterization of additional potentially active peptides produced by the igf1 gene. Alternative splicing of the gene results in multiple isoforms that retain the identical sequence for mature IGF-I, but also give rise to divergent C-terminal peptides. The peptides might modulate the actions, stability, or bioavailability of IGF-I, or they might have independent activity. These possibilities have gained the attention of the skeletal muscle field, where novel actions of IGF-I could have significant impact on muscle mass, strength, and repair.
Time-resolved rise of iodine molecule (1-) upon oxidation of iodide at aqueous titania colloid (1993)

GR-MO
Two-dimensional simulation of an alternating current matrix plasma display cell: Cross-talk and other geometric effects (1998)

A two-dimensional, user-friendly model of the discharge occurring in a plasma display panel cell was developed. This model was used to study the transient discharges in an alternating current plasma display with a matrix electrode configuration. The space and time variations of the charge particle densities, excitation rates, electric potential, and surface charge densities are described. The model is also used to study the conditions of existence of electrical interaction between adjacent cells and the effects of electrode misalignment.
Measuring Factors that Influence the Success of Internet Commerce (2002)

Efforts to develop measures of Internet commerce success have been hampered by (1) the rapid development and use of Internet technologies and (2) the lack of conceptual bases necessary to develop success measures. In a recent study, Keeney (1999) proposed two sets of variables labeled as means objectives and fundamental objectives that influence Internet shopping. Means objectives, he argues, help businesses achieve what is important for their customers—fundamental objectives. Based on Keeney's work, this paper describes the development of two instruments that together measure the factors that influence Internet commerce success. One instrument measures the means objectives that influence online purchase (e.g., Internet vendor trust) and the other measures the fundamental objectives that customers perceive to be important for Internet commerce (e.g., Internet product value). In phase one of the instrument development process, we generated 125 items for means and fundamental objectives. Using a sample of 199 responses by individuals with Internet shopping experience, these constructs were examined for reliability and validity. The Phase 1 results suggested a 4-factor, 21-item instrument to measure means objectives and a 4-factor, 17-item instrument to measure fundamental objectives. In Phase 2 of the instrument development process, we gathered a sample of 421 responses to further explore the 2 instruments. With minor modifications, the Phase 2 data support the 2 models. The Phase 2 results suggest a 5-factor, 21-item instrument that measures means objectives in terms of Internet product choice, online payment, Internet vendor trust, shopping travel, and Internet shipping errors. Results also suggest a 4-factor, 16-item instrument that measures fundamental objectives in terms of Internet shopping convenience, Internet ecology, Internet customer relation, and Internet product value. Evidence of reliability and discriminant, construct, and content validity is presented for the hypothesized measurement models. The paper concludes with discussions on the usefulness of these measures and future research ideas.
Decoding Movement Intent From Human Premotor Cortex Neurons for Neural Prosthetic Applications (2006)

Primary motor cortex (M1), a key region for voluntary motor control, has been considered a first choice as the source of neural signals to control prosthetic devices for humans with paralysis. Less is known about the potential for other areas of frontal cortex as prosthesis signal sources. The frontal cortex is widely engaged in voluntary behavior. Single-neuron recordings in monkey frontal cortex beyond M1 have readily identified activity related to planning and initiating movement direction, remembering movement instructions over delays, or mixtures of these features. Human functional imaging and lesion studies also support this role. Intraoperative mapping during deep brain stimulator placement in humans provides a unique opportunity to evaluate potential prosthesis control signals derived from nonprimary areas and to expand our understanding of frontal lobe function and its role in movement disorders. This study shows that recordings from small groups of human prefrontal/premotor cortex neurons can provide information about movement planning, production, and decision-making sufficient to decode the planned direction of movement. Thus, additional frontal areas, beyond M1, may be valuable signal sources for human neuromotor prostheses.
On‐line determination of animal cell concentration in two industrial high‐density culture processes by dielectric spectroscopy (2001)

Dielectric spectroscopy was applied to two industrial high cell density culture processes and used to determine on-line the concentration of CHO cells immobilized on macroporous microcarriers in a stirred bioreactor and in a packed-bed of disk carriers. The cell concentration predicted from the spectroscopic data was in excellent agreement with off-line cell counting data for both processes. Deviations between the two counting methods only occurred in the case of a significant decrease of the cell viability, from 93% to 64%, which induced a change of the average cell size in the culture. Results for the packed-bed process were further confirmed by the application of indirect yield models based on the measurement of glucose, lactate, and the protein of interest. Moreover, dielectric spectroscopy was used as a tool to characterize the packed-bed process. It was possible to determine both the maximum cell concentration that could be reached in the culture system, 2.0 x 10(11) cell per kg of disk carrier, and to quantify the increase of specific protein productivity induced by the production phase, from 5.14 x 10(-8) microg x cell(-1) x h(-1) to 4.24 x 10(-7) microg x cell(-1) x h(-1).
A new chemically amplified electrochemical system for the detection of biological affinity reactions: direct and competitive biotin assay (2005)

Quantitation of biological affinity reactions by a newly developed chemically amplified electrochemical detection method was demonstrated with the biotin-avidin binding pair. In the method, ruthenium tris(2,2'-bipyridine)(Ru-bipy) was used as an electrochemical signal-generating tag. Its oxidation current on an indium tin oxide (ITO) electrode was amplified with a sacrificial electron donor, oxalate. Because oxalate itself produced negligible current on the electrode, the signal-to-background ratio was greatly enhanced in comparison with other chemical amplification systems. Although the Ru-bipy/oxalate redox couple has been employed previously in electrochemiluminescent and photoelectrochemical detection, its use in a catalytic amperometric detection of biological binding assays has not been reported. To implement the method in the detection of biotin-avidin recognition, avidin was immobilized on an ITO electrode, and was reacted with biotin in solution. Immobilization of avidin by passive adsorption was found to be relatively stable under the condition of the affinity reaction. In the direct assay, biotin labelled with Ru-bipy was recognized by avidin and accumulated on the electrode surface, which was then detected electrochemically in the presence of oxalate. A linear relationship between electrochemical current and biotin concentration was obtained in the range of 1-300 ng mL(-1). In the competitive assay, a mixed solution of unlabelled biotin (the analyte) of various concentrations and 100 ng mL(-1) labelled biotin was reacted with avidin on the surface. As the concentration of the unlabelled biotin increased, less labelled biotin bound to avidin, leading to a reduction in the electro-catalytical response of Ru-bipy. A detection limit of 1 ng mL(-1) biotin was obtained in the competitive assay, which is close to the sensitivity of some enzyme-labelled amperometric assays.
[Nuclear matrix protein pattern in human hepatocellular carcinoma]. (1997)

There are HCC-specific nuclear matrix proteins which may be related to the etiology and pathogenesis of HCC.