gebhart/patrepeval huggingface dataset:
Transport properties and thermoelectric performance of (Zn1−yMgy)1−xAlxO (1998)

Addition of MgO to Al-doped ZnO was successful in reduction of the phonon thermal conductivity,κph , in order to suppress the unfavorably high thermal conductivity, κ, of the material in terms of applications to thermoelectric conversion. The electrical conductivity, σ, of Zn0.98Al0.02O decreased with increasing amount of the added MgO, whereas the Seebeck coefficient was virtually unchanged up to (Zn0.9Mg0.1)0.98Al0.02O. Further Al2O3 doping was ineffective in improving σ. The carrier mobility decreased with increasing amount of the added MgO but was independent of the extent of the Al doping. In spite of the significant suppression of κ, the figure of merit was smaller for the MgO-added samples because of the marked decrease of σ.
An Atlas of Cellular Oscillators (1979)

ABSTRACT Rapidly accumulating evidence suggests that periodic behaviour is not confined to a limited number of cell types but is a common property of most biological systems. The argument for this proposition is presented by systematically cataloguing an atlas of biological and biochemical oscillators with periods of an hour or less. The listing consists of eight principal sections .and includes oscillations in secretory cells, neural oscillators, oscillations in muscle cells and rhythmic behaviour in growth and development. Each entry states the experimental preparation, the periodic event (the observed oscillatory variable), the period and lists references to the experimental literature. Four hundred and fifty experimental papers are cited.
Blind equalization based on second and fourth order statistics (1990)

A novel blind and adaptive equalization scheme is introduced for nonminimum phase communication channels. A classical least-mean-squares type predictor is used for the identification and equalization of the amplitude information of the channel. Independently, phase correction is carried out with a method based on noncausal autoregressive moving average modelling of the fourth-order cumulants of the received signal sequence. It is shown by means of computer simulation examples that the proposed equalizer has very good convergence speed and low start-up symbol error rate.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Bioinspired Polymer Vesicles Based on Hydrophilically Modified Polybutadienes (2007)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTBioinspired Polymer Vesicles Based on Hydrophilically Modified PolybutadienesZofia Hordyjewicz-Baran, Liangchen You, Bernd Smarsly, Reinhard Sigel, and Helmut SchlaadView Author Information Max Planck Institute of Colloids and Interfaces, Colloid Chemistry, Research Campus Golm, 14424 Potsdam, Germany Cite this: Macromolecules 2007, 40, 11, 3901–3903Publication Date (Web):April 26, 2007Publication History Received9 February 2007Revised4 April 2007Published online26 April 2007Published inissue 1 May 2007https://pubs.acs.org/doi/10.1021/ma070347nhttps://doi.org/10.1021/ma070347nrapid-communicationACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views1881Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Hydrophilicity,Membranes,Polymers,Scattering,Vesicles Get e-Alerts
A cache coherence scheme with fast selective invalidation (1988)

Software-assisted cache coherence enforcement schemes for large multiprocessor systems with shared global memory and interconnection network have gained increasing attention. Proposed software-assisted approaches rely on either indiscriminate invalidation or selective invalidation to invalidate stale cache lines. The indiscriminate approach combined with advanced memory hardware can quickly invalidate the entire cache but may result in lower hit ratios. The selective approach may achieve a better hit ratio. However, sequential selection and invalidation of cache or TLB entries is time consuming. We propose a new solution that offers the fast operation of the indiscriminate invalidation approach and can selectively invalidate cache items without extensive run-time book-keeping and checking. The solution relies on the combination of compile-time reference tagging and individual invalidation of potentially stale cache lines only when referenced. Performance improvement over an indiscriminate invalidation approach is presented.
Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein (1992)

Polyclonal antibodies were raised against a multiprotein 'holoenzyme' form of calf thymus DNA polymerase alpha-primase and used to probe a human cDNA-protein expression library constructed in the lambda gt11 vector. The probe identified a series of cDNA clones derived from a 3.2 kb mRNA which encodes a novel 105 kDa polypeptide, the P1 protein. In intact cells, the P1 protein was specifically associated with the nucleus, and in cell extracts, it was associated with complex forms of DNA polymerase alpha-primase. The synthesis of human P1-specific mRNA was stimulated upon addition of fresh serum to growth-arrested cells, and RNA blot analyses with the human P1-cDNA probe indicated that P1 is encoded by a strictly conserved mammalian gene. The amino acid sequence deduced from a 240-codon open reading frame resident in the largest human P1-cDNA (0.84 kb) displayed greater than 96% identity with that deduced from the equivalent segment of a 795-codon open reading frame of a larger mouse P1-cDNA (2.8 kb). Throughout its length, the primary structure of mammalian P1 displayed strong homology with that of Mcm3, a 125 kDa yeast protein thought to be involved in the initiation of DNA replication (Gibson et al. 1990. Mol. Cell. Biol. 10: 5707-5720). The P1-Mcm3 homology, the strong conservation of P1 among mammals, its nuclear localization, and its association with the replication-specific DNA polymerase alpha strongly suggest an important role of the P1 protein in the replication of mammalian DNA.
Improved Large-Scale Preparation of 4-Iodopicolinic Acid (1996)

Abstract Dimethylformamide showed a dramatic catalytic effect in the chlorination of picolinic acid with thionyl chloride. Methyl 4-chloropicolinate was directly transformed to 4-iodopicolinic acid in a good yield.
Purines. IX. Reaction of 9-Phenyl-9H-purine-2-carbonitriles with Grignard Reagents (1990)

The palladium-catalyzed cross-coupling r e a c t i o n of 2-and 6-chloro-9-phenyl-9H-purines with potassium cyanide proceeded t o g i v e 9-phenyl-9H-purine-2-(3a-c) and -6-carbon i t r i l e s ( 4 a -c ) .The conversion of t h e cyano group a t t h e 2-pos i t i o n i n t o t h e corresponding a c y l groups was achieved by t r e a tment of 3a,b with Grignard r e a g e n t s .W e r e p o r t e d t h a t 9-phenyl-9H-purine-2-( 3 a ) and -6 -c a r b o n i t r i l e s (4a) were synthes i z e d from 2-and 6-(rnethylsulfony1)-9-phenyl-9H-purines and potassium cyanide ( K C N ) 2 r 3 and t h e s e l e c t i v e a d d i t i o n of t h e n u c l e o p h i l e s t o the cyano group a t the 6 -p o s i t i o n of t h e 9H-purine took p l a c e .4 I t i s w e l l known t h a t t h e cross-coupling r e a c t i o n of a r y l h a l i d e s with KCN i n t h e presence of a palladium complex was e ff e c t i v e f o r p r e p a r a t i o n of a r y l c y a n i d e s .5
Tagging of Endogenous Genes in a <i>Toxoplasma gondii</i> Strain Lacking Ku80 (2009)

As with other organisms with a completed genome sequence, opportunities for performing large-scale studies, such as expression and localization, on Toxoplasma gondii are now much more feasible. We present a system for tagging genes endogenously with yellow fluorescent protein (YFP) in a Deltaku80 strain. Ku80 is involved in DNA strand repair and nonhomologous DNA end joining; previous studies in other organisms have shown that in its absence, random integration is eliminated, allowing the insertion of constructs with homologous sequences into the proper loci. We generated a vector consisting of YFP and a dihydrofolate reductase-thymidylate synthase selectable marker. The YFP is preceded by a ligation-independent cloning (LIC) cassette, which allows the insertion of PCR products containing complementary LIC sequences. We demonstrated that the Deltaku80 strain is more effective and efficient in integrating the YFP-tagged constructs into the correct locus than wild-type strain RH. We then selected several hypothetical proteins that were identified by a proteomic screen of excreted-secreted antigens and that displayed microarray expression profiles similar to known micronemal proteins, with the thought that these could potentially be new proteins with roles in cell invasion. We localized these hypothetical proteins by YFP fluorescence and showed expression by immunoblotting. Our findings demonstrate that the combination of the Deltaku80 strain and the pYFP.LIC constructs reduces both the time and cost required to determine localization of a new gene of interest. This should allow the opportunity for performing larger-scale studies of novel T. gondii genes.
[An analysis of the results of clinical trials of praziquantel analogs in intestinal cestode and trematode infections. 2. The treatment of liver trematode infections (opisthorchiasis, fascioliasis) and schistosomiasis]. (1994)

The authors did not detect any differences in the efficacies and tolerance of praziquantel analogs manufactured by various firms (azinox, Russia; pikitor, China; cesol, cisticide, biltricide, Bayer, Merk, Germany, India). These drugs were found highly effective in opisthorchiasis (87.8%) and schistosomiasis (91.7%) and ineffective in fascioliasis. The efficacy and tolerance of azinox, a drug manufactured in this country, was similar to those of its foreign analogs.
Electrolyte optimization and electrode material evaluation for the vanadium redox battery (1989)

In this project the preparation of the electrolyte for the all vanadium redox flow battery was investigated using both chemical and electrolytic reduction of ^O,- powder. Oxalic acid and SO^ reduction were found to be unsuitable as only the V(IV) state could be produced directly. With suspended powder hydrolysis, however, vanadium sulphate of any oxidation state, in this case 50% V(IV) plus 50% V(III) in sulphuric acid can readily be prepared from V^O^ powder, thus allowing a significant reduction in the cost of the vanadium battery electrolyte. Results from conductivity and electrolyte stability tests at elevated temperature have led to modification of the electrolyte composition for the vanadium redox cell, from the 2 M V plus 2 M H^SO^, originally employed, to the use of 3 M H^SO^, much higher energy efficiencies and greater electrolyte stability was demonstrated with the 3 M H^SO^ supporting electrolyte. Spectroscopy and electrolyte conductivity have been demonstrated as suitable techniques for state-of-charge monitoring. A number of electrode materials were also evaluated and a Toray graphite bonded to a carbon plastic electrode was selected for further prototype development. Energy efficiencies of between 83 and 86% were obtained for a current density of 30 mA/cm for a temperature range 5 to 45'C, and between 0 and 100% state-of-charge. A wide range of construction materials was tested for long term stability in the vanadium redox electrolyte.
Resistive, Capacitive, Inductive, and Magnetic Sensor Technologies (2014)

Sensor technologies have experienced dramatic growth in recent years, making a significant impact on national security, health care, environmental improvement, energy management, food safety, construction monitoring, manufacturing and process control, and more. However, education on sensor technologies has not kept pace with this rapid development
A voltage-independent calcium current inhibitory pathway activated by muscarinic agonists in rat sympathetic neurons requires both Galpha q/11 and Gbeta gamma. (2000)

Calcium current modulation by the muscarinic cholinergic agonist oxotremorine methiodide (oxo-M) was examined in sympathetic neurons from the superior cervical ganglion of the rat. Oxo-M strongly inhibited calcium currents via voltage-dependent (VD) and voltage-independent (VI) pathways. These pathways could be separated with the use of the specific M(1) acetylcholine receptor antagonist M(1)-toxin and with pertussis toxin (PTX) treatment. Expression by nuclear cDNA injection of the regulator of G-protein signaling (RGS2) or a phospholipase Cbeta1 C-terminal construct (PLCbeta-ct) selectively reduced VI oxo-M modulation in PTX-treated and untreated cells. Expression of the Gbetagamma buffers transducin (Galpha(tr)) and a G-protein-coupled-receptor kinase (GRK3) construct (MAS-GRK3) eliminated oxo-M modulation. Activation of the heterologously expressed neurokinin type 1 receptor, a Galpha(q/11)-coupled receptor, resulted in VI calcium current modulation. This modulation was eliminated with coexpression of Galpha(tr) or MAS-GRK3. Cells expressing Gbeta(1)gamma(2) were tonically inhibited via the VD pathway. Application of oxo-M to these cells produced VI modulation and reduced the amount of current inhibited via the VD pathway. Together, these results confirm the requirement for Gbetagamma in VD modulation and implicate Galpha(q)-GTP and Gbetagamma as components in the potentially novel VI pathway.
Electrochemistry of tin deposition from mixed sulphate and methanesulphonate electrolyte (2008)

AbstractAbstractThe electrodeposition of tin, at a copper surface, from a tin sulphate (0˙014 mol dm–3) electrolyte containing methanesulphonic acid (12 ˙5 vol.-%) at 295 K has been studied. Cyclic voltammetry, using potential sweep rates of 8–128 mV s–1, at a stationary copper electrode provided information on the potential ranges for tin deposition and stripping. Linear sweep voltammetry, at a copper rotating disc electrode was used to evaluate the mass transport characteristics of the system under controlled, laminar flow conditions. The changes in the limiting current density with a Sn2+ concentration of 0˙006–0˙078 mol dm–3 and an electrode rotation rate of 200–4800 rev min–1 were quantified. Randles-Sevčik and Levich equations were used to give an averaged diffusion coefficient for Sn2+ of 5˙4 × 10–6 cm2 s–1.Keywords: CHARGE TRANSFER CONTROLCYCLIC VOLTAMMETRYLINEAR SWEEP VOLTAMMETRYMASS TRANSPORT CONTROLROTATING DISC ELECTRODETIN DEPOSITION AND STRIPPING
Inflammation, Autophagy, and Apoptosis After Myocardial Infarction (2018)

These observations suggest that inflammatory response may be protective in the early stage of the myocardial infarction through stimulation of myocyte autophagy. Anti-inflammatory treatment early after coronary occlusion may have an adverse effect.
Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from <i>Leptospira interrogans</i> (2008)

Leptospira interrogans is the causative agent for leptospirosis, a zoonotic disease of global importance. In contrast with most other micro-organisms, L. interrogans employs a pyruvate pathway to synthesize isoleucine and LiCMS (L. interrogans citramalate synthase) catalyses the first reaction of the pathway which converts pyruvate and acetyl-CoA into citramalate, thus making it an attractive target for the development of antibacterial agents. We report here the crystal structures of the catalytic domain of LiCMS and its complexes with substrates, and kinetic and mutagenesis studies of LiCMS, which together reveal the molecular basis of the high substrate specificity and the catalytic mechanism of LiCMS. The catalytic domain consists of a TIM barrel flanked by an extended C-terminal region. It forms a homodimer in the crystal structure, and the active site is located at the centre of the TIM barrel near the C-terminal ends of the beta-strands and is composed of conserved residues of the beta-strands of one subunit and the C-terminal region of the other. The substrate specificity of LiCMS towards pyruvate against other alpha-oxo acids is dictated primarily by residues Leu(81), Leu(104) and Tyr(144), which form a hydrophobic pocket to accommodate the C(2)-methyl group of pyruvate. The catalysis follows the typical aldol condensation reaction, in which Glu(146) functions as a catalytic base to activate the methyl group of acetyl-CoA to form an enolated acetyl-CoA intermediate and Arg(16) as a general acid to stabilize the intermediate.
Generation and Characterization of Photopolymerized Polymer Brush Gradients (2006)

A novel method for using photoiniferter-mediated photopolymerization techniques to create surface-bound macromolecular assemblies exhibiting position-dependent molecular weights, surface densities, and layer thicknesses has been developed. By using a variable photomasking system and judiciously selecting photopolymerization parameters, such as monomer concentration and light intensity, poly(methyl methacrylate) (PMMA) surfaces exhibiting layer thickness gradients were photopolymerized on single silicon substrates from self-assembled monolayers of photoiniferter. The ability to precisely control the topographic slope of a surface-tethered polymer brush gradient was achieved by varying surface irradiation time or bulk monomer concentration. Kinetics of surface-gradient formation were measured using variable angle ellipsometry as well as transmission Fourier transform infrared spectroscopy. Under the conditions studied, the photopolymerization of PMMA exhibited first-order dependence of polymer brush layer thickness on both monomer concentration and surface irradiation time even though the polymer chain ends could not be reinitiated as should occur with a living-radical system.
Lycopene inhibits growth of human colon cancer cells <i>via</i> suppression of the Akt signaling pathway (2008)

The aberrant regulation of the phosphoinositide 3-kinase/Akt survival signaling pathway in cancer has prompted significant interest in suppression of this pathway to treat cancer. Previous studies identified an important role for phosphoinositide 3-kinase/Akt in colon cancer progression. Lycopene, a major component in tomato, exhibited potential anti-carcinogenic activity. Consumption of tomato has been associated with reduced risk of several types of human cancer. However, the inhibitory mechanisms of lycopene on the proliferation of human colon cancer have not been studied well yet. Thus we investigated the inhibitory effects of lycopene on the Akt signaling pathway in human colon cancer HT-29 cells. Lycopene inhibited cell proliferation in human colon cancer HT-29 cells with a IC(50) value of 10 microM. Lycopene treatment suppressed Akt activation and non-phosphorylated beta-catenin protein level in human colon cancer cells. Immunocytochemical results indicated that lycopene increased the phosphorylated form of beta-catenin proteins. These effects were also associated with reduced promoter activity and protein expression of cyclin D1. Furthermore, lycopene significantly increased nuclear cyclin-dependent kinase inhibitor p27(kip)abundance and inhibited phosphorylation of the retinoblastoma tumor suppressor protein in human colon cancer cells. In conclusion, lycopene inhibited cell proliferation of human colon cancer cells via suppression of the Akt signaling pathway and downstream targeted molecules.
A 1.2 V, Inductorless, Broadband LNA in 90 nm CMOS LP (2007)

This paper presents a novel broadband, inductorless, resistive-feedback CMOS LNA. The LNA is designed for the frequency band 0.4 - 1 GHz. The measured power gain of the LNA is 16 dB at 1 GHz and the 3-dB bandwidth is 2 GHz. A noise figure of 3.5 dB and an IIP3 of -17 dBm are measured at 900 MHz. The <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">S11</i> is better than -10 dB in the frequency band from 300 MHz up to 1 GHz. The current consumption is 14 mA from a 1.2 V supply. The circuit is designed in a baseline CMOS 90 nm low power (LP) process.
Protein-protein Interaction Networks: from Interactions to Networks (2004)

The goal of interaction proteomics that studies the protein-protein interactions of all expressed proteins is to understand biological processes that are strictly regulated by these interactions. The availability of entire genome sequences of many organisms and high-throughput analysis tools has led scientists to study the entire proteome (Pandey and Mann, 2000). There are various high-throughput methods for detecting protein interactions such as yeast two-hybrid approach and mass spectrometry to produce vast amounts of data that can be utilized to decipher protein functions in complicated biological networks. In this review, we discuss recent developments in analytical methods for large-scale protein interactions and the future direction of interaction proteomics.
Special Feature: An On-Line Data Entry System for Hand-Printed Characters* (1977)

The primary method of entering large amounts of routinely produced, hand-printed data into computer systems is via manual keyboards. Manual retranscription, however, entails a number of disadvantages such as extra cost, delays, and errors.
Adaptive coding and modulation for return satellite links using binary turbo coding (2010)

A turbo code that is based on an 8-state binary constituent code is considered in this paper for use in an adaptive coding and modulation system for a return satellite link. The paper presents the results of finding good puncture-constrained dithered relative prime interleavers along with data puncture patterns to provide the required performance. A tradeoff between waterfall and flare performance can be made by selecting the best puncture masks for the required error rate. The performance of the turbo code with a packet size of 1504 data bits is presented for the following modulations: BPSK, QPSK, 8 PSK and 16 APSK. A comparison with other coding strategies shows that this code is an attractive option for use in a return satellite link application using adaptive coding and modulation.
Parsing with generative models of predicate-argument structure (2003)

The model used by the CCG parser of Hockenmaier and Steedman (2002b) would fail to capture the correct bilexical dependencies in a language with freer word order, such as Dutch. This paper argues that probabilistic parsers should therefore model the dependencies in the predicate-argument structure, as in the model of Clark et al. (2002), and defines a generative model for CCG derivations that captures these dependencies, including bounded and unbounded long-range dependencies.