gebhart/patrepeval huggingface dataset:
A Nanocomposite Chitosan Based on Ferrocene‐Modified Silica Nanoparticles and Carbon Nanotubes for Biosensor Application (2007)

Abstract A novel amperometric biosensor for glucose was developed by entrapping glucose oxidase (GOD) in a chitosan composite doped with ferrocene monocarboxylic acid‐aminated silica nanoparticles conjugate (FMC‐ASNPs) and multiwall carbon nanotubes (MWNTs). The entrapped FMC‐ASNPs conjugate performed excellent redox electrochemistry and the presence of MWNTs improved the conductivity of the composite film. This matrix showed a biocompatible microenvironment for retaining the native activity of the entrapped GOD and was in favor of the accessibility of substrate to the active site of GOD, thus the affinity to substrates is improved greatly. Under optimal conditions this biosensor was able to detect glucose with a detection limit of 10 μM ( S / N =3) in the linear range of 0.04 to 6.5 mM. The proximity of these three components FMC‐ASNPs, MWNTs and GOD enhanced the electron transfer between the film and electrode. This composite film can be extended to immobilize other enzymes and biomolecules, which will greatly facilitate the development of biosensors and other bioelectrochemical devices.
Effect of varying chromophores used in light-activated protein solders on tensile strength and thermal damage profile of repairs. (2003)

Clinical adoption of laser tissue welding (LTW) techniques has been beleaguered by problems associated with thermal damage of tissue and insufficient strength of the resulting tissue bond. The magnitude of these problems has been significantly reduced with the incorporation of indocyanine green (ICG)-doped protein solders into the LTW procedure to form a new technique known as laser tissue soldering (LTS). With the addition of ICG, a secondary concern has arisen relating to the potential harmful effects of the degradation products of the chromophore upon thermal denaturation of the protein solder with a laser. In this study, two different food colorings were investigated, including blue #1 and green consisting of yellow #5 and blue #1, as alternative chromophores for use in LTS techniques. Food coloring has been found to have a suitable stability and safety profile for enteral use when heated to temperatures above 200 degrees C; thus, it is a promising candidate chromophore for LTS which typically requires temperatures between 50 degrees C and 100 degrees C. Experimental investigations were conducted to test the tensile strength of ex vivo repairs formed using solders doped with these alternative chromophores in a bovine model. Two commonly used chromophores, ICG and methylene blue (MB), were investigated as a reference. In addition, the temperature rise, depth of thermal coagulation in the protein solder, and the extent of thermal damage in the surrounding tissue were measured. Temperature rise at the solder/tissue interface, and consequently the degree of solder coagulation and collateral tissue thermal damage, was directly related to the penetration depth of laser light in the protein solder. Variation of the chromophore concentration such that the laser light penetrated to a depth approximately equal to half the thickness of the solder resulted in uniform results between each group of chromophores investigated. Optimal tensile strength of repairs was achieved by optimizing laser and solder parameters to obtain a temperature of approximately 65 degrees C at the solder/tissue interface. The two alternative chromophores tested in this study show considerable promise for application in LTS techniques, with equivalent tensile strength to solders doped with ICG or MB, and the potential advantage of eliminating the risks associated with harmful byproducts.
Automatic Identification of a PMSM Drive Equipped with an Output LC-Filter (2006)

The following paper presents a fully automatic method of the identification of a field oriented controlled drive. The examined system consists of a permanent magnet synchronous machine PMSM, a sinus-filter (LC-filter) and an inverter. The advantage of the utilization of the filter in such systems lies in the decrease of the current and torque ripple, besides it features lower EMI production. The voltage stress on the windings of the machine is also lower. Despite the increased order of the system, the necessary number of sensors is not higher than in an application without filter. The identification of the system allows the utilization of the presented method in a wide range of industrial applications
Transgression et identification dans le passage à l'acte (2003)

<titre>Résumé</titre> Dans certains passages à l’acte criminels, il s’agit d’une transgression perverse de la loi ; mais dans de nombreux autres cas, où l’auteur de l’acte est psychotique, il agit au nom d’une mission idéale ou bien parce qu’il s’identifie à un objet pulsionnel qui concentre l’enjeu de son existence. Dans ce dernier cas, le sujet ne peut absolument pas assumer son acte, sauf dans un temps parfois très long après celui-ci, et les notions de responsabilité et de châtiment deviennent de ce fait extrêmement problématiques.
Lamella and tube settlers. 2. Flow stability (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLamella and tube settlers. 2. Flow stabilityWoon Fong LeungCite this: Ind. Eng. Chem. Process Des. Dev. 1983, 22, 1, 68–73Publication Date (Print):January 1, 1983Publication History Published online1 May 2002Published inissue 1 January 1983https://pubs.acs.org/doi/10.1021/i200020a012https://doi.org/10.1021/i200020a012research-articleACS PublicationsRequest reuse permissionsArticle Views195Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A method to retrieve super-thin cloud optical depth over ocean background with polarized sunlight (2015)

Abstract. In this work, an algorithm that uses the polarization angle of the backscattered solar radiation to detect clouds with optical depth (OD) < ~ 0.3 is further developed. We find that at viewing angles within ± ∼ 8° around the backscattering direction, the p-polarized intensity that is parallel to the meridian plane of reflected light from the surface is sensitive to, and nearly linearly related to, the optical depth of super-thin clouds. Moreover, our sensitivity study suggests that the p-polarized intensity at these viewing angles is not sensitive to the ocean surface conditions. Using this property of p-polarized intensity, super-thin clouds' optical depth can be retrieved.
Testing and troubleshooting IEC 61850 GOOSE-based control and protection schemes (2010)

IEC 61850 GOOSE (Generic Object-Oriented Substation Event) provides many advantages, including flexibility and reduced wiring, but introduces new challenges. Traditional tools and techniques cannot check the status of contacts and coils between intelligent electronic devices (IEDs) in a GOOSE-based scheme. Data on Ethernet networks are generally not documented in traditional substation wiring or elementary diagrams. The previous generations of relay test sets are not equipped to monitor GOOSE messages from relays. As hard-wired schemes are converted to GOOSE-based schemes, test personnel need new tools to document, test, and troubleshoot these schemes. New tools include the following: (1) New documentation (2) Relay communications diagnostics (3) Managed switches (4) Network protocol analyzers (5) GOOSE-enabled relay test sets. This paper describes and compares the use of these new tools with traditional testing techniques.
The Effects of Substituent Grafting on the Interaction of pH-Responsive Polymers with Phospholipid Monolayers (2011)

pH-responsive amphiphilic polymers with suitable graftings have demonstrated highly efficient cell membrane activity and hence are promising applicants for drug-delivery. Grafting the hydrophobic amino acid l-phenylalanine and the hydrophilic methoxy poly(ethylene glycol) amine onto the pendant carboxylic acid moieties of a linear polyamide, poly(l-lysine isophthalamide), can effectively modify the amphiphilicity and conformation of the amphiphilic polymers. Here, the interactions of these polymers with phospholipid monolayers adsorbed on mercury (Hg) electrodes have been studied. AC voltammetry (ACV), rapid cyclic voltammetry (RCV), and electrochemical impedance spectroscopy (EIS) have been applied to monitor phospholipid monolayer associations with different polymer concentrations under different pH values. The polymers interact reversibly with the monolayer shown by altering the monolayer capacitance and inhibiting the phospholipid reorientation in electric field. Polymer grafting enhances the pH-mediated conformational change of the polymers which in turn increases their phospholipid monolayer activity. The most significant monolayer interactions have been observed with the polymer grafted with hydrophobic l-phenylalanine. A low level of PEGylation of the backbone also increases the monolayer activity. The polymer/DOPC interactions have been represented with an impedance model, which takes account of the interaction giving rise to an increase in monolayer capacitance and inhomogeneity and a Debye type dielectric relaxation. The extent of penetration of the polymers into the monolayer is inversely related to the electrical resistance they give rise to during the Debye relaxation. The cell membrane activities of these amphiphilic polymers have been successfully mirrored in this supported DOPC monolayer system, isolating the key parameters for biomembrane activities and giving insight into the mechanism of the interactions. The conclusions from this study provide strategic directions in material design catering to different requirements in biomedical applications.
Monolithic GaAs p-i-n diode switch circuits for high-power millimeter-wave applications (1989)

Two different Ka-band single-pole, double-throw (SPDT) switch circuits using monolithic GaAs epitaxial p-i-n diode technology are presented. The lowest insertion loss is 0.7 dB at 35 GHz, and isolation is better than 32 dB from 30 to 40 GHz. The power-handling capability is at least +38 dBm pulsed and +35 dBm continuous wave. Switching speed rise- and fall times are 2 ns.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
X-Ray Diagnostics. VI. Diiodohydroxydihydrostilbazoles and Related Compounds (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTX-Ray Diagnostics. VI. Diiodohydroxydihydrostilbazoles and Related CompoundsDomenick Papa, Erwin Schwenk, and Erwin KlingsbergCite this: J. Am. Chem. Soc. 1951, 73, 1, 253–255Publication Date (Print):January 1, 1951Publication History Published online1 May 2002Published inissue 1 January 1951https://pubs.acs.org/doi/10.1021/ja01145a085https://doi.org/10.1021/ja01145a085research-articleACS PublicationsRequest reuse permissionsArticle Views114Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Limits of peripheral acuity and implications for VR system design (2018)

Abstract At different retinal locations, we measured the visual system's sensitivity to a number of artifacts that can be introduced in near‐eye display systems. One study examined the threshold level of downsampling that an image can sustain at different positions in the retina and found that temporally stable approaches, both blurred and aliased, were much less noticeable than temporally volatile approaches. Also, boundaries between zones of different resolution had low visibility in the periphery. We also examined the minimum duration needed for the visual system to detect a low‐resolution region in an actively tracked system and found that low‐resolution images presented for less than 40 ms before being replaced with a high‐resolution image are unlikely to be visibly degraded. We also found that the visual system shows a rapid falloff in its ability to detect chromatic aberration in the periphery. These findings can inform the design on high performance and computationally efficient near‐eye display systems.
School Violent Crime and Academic Achievement in Chicago (2013)

Educational outcomes vary dramatically across schools in the United States. Many under-performing schools, especially in Chicago, also deal with high levels of violent crime on school grounds. Exposure to this type of frequent violence may be an important factor shaping already disadvantaged students' educational experiences. However, estimating the effect of school violence on learning is difficult due to potential selection bias and the confounding of other school-level problems. Using detailed crime data from the Chicago Police Department, complete administrative records from the Chicago Public Schools, and school climate surveys conducted by the Consortium on Chicago School Research (2002-10), this study exploits variation in violent crime rates within schools over time to estimate its effect on academic achievement. School and neighborhood fixed-effects models show that violent crime rates have a negative effect on test scores, but not on grades. This effect is more likely related to direct reductions in learning, through cognitive stress and classroom disruptions, than changes in perceived safety, general school climate, or discipline practices.
Autopilot: An Online Data Acquisition Control System for the Enhanced High-Throughput Characterization of Intact Proteins (2014)

The ability to study organisms by direct analysis of their proteomes without digestion via mass spectrometry has benefited greatly from recent advances in separation techniques, instrumentation, and bioinformatics. However, improvements to data acquisition logic have lagged in comparison. Past workflows for Top Down Proteomics (TDPs) have focused on high throughput at the expense of maximal protein coverage and characterization. This mode of data acquisition has led to enormous overlap in the identification of highly abundant proteins in subsequent LC-MS injections. Furthermore, a wealth of data is left underutilized by analyzing each newly targeted species as unique, rather than as part of a collection of fragmentation events on a distinct proteoform. Here, we present a major advance in software for acquisition of TDP data that incorporates a fully automated workflow able to detect intact masses, guide fragmentation to achieve maximal identification and characterization of intact protein species, and perform database search online to yield real-time protein identifications. On Pseudomonas aeruginosa, the software combines fragmentation events of the same precursor with previously obtained fragments to achieve improved characterization of the target form by an average of 42 orders of magnitude in confidence. When HCD fragmentation optimization was applied to intact proteins ions, there was an 18.5 order of magnitude gain in confidence. These improved metrics set the stage for increased proteome coverage and characterization of higher order organisms in the future for sharply improved control over MS instruments in a project- and lab-wide context.
A microcontroller-based PVT control system for a 65nm 72Mb synchronous SRAM (2010)

We present a manufacturable scheme for managing PVT variations and controlling speed and power consumption by using an on-chip microcontroller and a temperature sensor. The system varies body-bias and power supplies of the memory core and periphery logic independently. The circuit occupies 0.32 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> (0.4%) of a 72 Mb SRAM test-chip in a 65 nm CMOS process.
DateLens (2004)

Calendar applications for small handheld devices are growing in popularity. This led us to develop DateLens, a novel calendar interface for PDAs designed to support complex tasks. It uses a fisheye representation coupled with compact overviews to give the big picture in a small space. The interface also gives users control over the visible time period, as well as supporting integrated search to discover patterns and outliers. Designed with device scalability in mind, DateLens currently runs on desktop computers as well as PDAs. Two user studies were conducted to examine the viability of DateLens as a replacement for traditional calendar visualizations. In the first study, non-PDA users performed complex tasks significantly faster with DateLens than with the Microsoft Pocket PC 2002 TM calendar (using a PDA emulator). In addition, they rated DateLens as being easier to use than the default calendar application for a majority of the tasks. In the second study, the participants were expert Pocket PC users and the software was run on their own devices. Again, DateLens performed significantly faster for the complex tasks, and there were satisfaction differences favoring each calendar for different kinds of tasks. From these studies, it is clear that DateLens is superior for more complex tasks such as those associated with longer time periods. For daily event tracking, users familiar with the default Pocket PC calendar strongly preferred its daily view and behaviors.
Insertional inactivation of Streptococcus pyogenes sod suggests that prtF is regulated in response to a superoxide signal (1996)

In establishing an infection, Streptococcus pyogenes has the capacity to bind to the host extracellular matrix protein fibronectin via its protein F adhesin. Previous studies have suggested that the expression of protein F is stimulated during aerobic growth or upon addition of superoxide-generating agents to the culture under O2-limited conditions. To further explore the role of superoxide, we have examined the transcription of the gene which encodes protein F (prtF), as well as the expression of superoxide dismutase (SOD) under conditions which promote or repress protein F expression. These studies show that prtF transcription is regulated in response to superoxide concentration and that SOD is regulated in different environments in a manner which directly parallels the expression of protein F. A mutant deficient in SOD activity was constructed by insertional mutation into the gene which encodes SOD (sod). The resulting mutant was sensitive to superoxide and aerobic conditions, showed hypersensitive induction of prtF in response to superoxide, and expressed prtF under normally unfavorable O2-limited conditions. These findings suggest that a streptococcal signal transduction system which senses superoxide may coordinately control expression of prtF and sod.
RCAD/BiP pathway is necessary for the proper synthesis of digestive enzymes and secretory function of the exocrine pancreas (2017)

Alcoholism causes an imbalance of endoplasmic reticulum (ER) homeostasis in pancreatic acini. In those cells, the ER is involved in the synthesis and folding of pancreatic enzymes. Ubiquitin-fold modifier 1 (Ufm1) is part of a novel ubiquitin-like modification system involved in maintaining ER homeostasis. Among the components of the Ufm1 system, Regulator of C53 and DDRGK1 (RCAD) has recently been identified as a Ufm1-specific E3 ligase that promotes ufmylation of DDRGK1, an RCAD-interacting protein. We determined the importance of RCAD in the proper synthesis and secretion of pancreatic enzymes using mice with genetically deleted RCAD. The pancreas of RCAD-deficient mice was of normal size and histology. Using quantitative PCR and Western blotting, we found that amylase was upregulated in pancreas organs from RCAD-knockout (KO) mice. Constitutive amylase secretion was much higher in isolated pancreatic acini from RCAD KO mice, whereas CCK-stimulated amylase secretion was disturbed. RCAD deficiency caused a downregulation in expression of ER chaperone BiP, which affected ER homeostasis and activated both apoptosis and trypsin. We also found that both RCAD and DDRGK1 transcript levels were upregulated in pancreatic acini from alcohol-preferring rats. Elevated expression of RCAD and DDRGK1 was associated with increased ER stress and UPR activation. Because of the lack of BiP expression, caspase 3 and trypsin activation we enhanced in RCAD-deficient pancreatic acini upon treatment with ethanol and CCK. In conclusion, the RCAD/BiP pathway is required for proper synthesis and secretion of pancreatic enzymes. In alcoholism, increased levels of components of the Ufm1 system could prevent the deleterious effects of alcohol in the pancreas by regulating BiP levels.<b>NEW & NOTEWORTHY</b> RCAD/BiP pathway is required for the proper synthesis and secretion of amylase from pancreatic acini, as well as for the maintenance of the ER homeostasis. In alcoholism, the exocrine pancreas could increase the levels of components of the Ufm1 system to protect itself from alcohol's deleterious effects by regulating the expression of ER chaperone BiP.
Effects of Sesquiterpene Lactones on Melanogenesis in Mouse B16 Melanoma Cells (2009)

In this study, we examined the effect of sesquiterpene lactones isolated from Calea urticifolia and Tanacetum parthenium (feverfew) on melanogenesis in mouse B16 melanoma cells. In response to 3-isobutyl-1-methylxanthin (IBMX), B16 melanoma cells underwent differentiation characterized by increased melanin biosynthesis. Treatment of sesquiterpene lactones at lower concentration (1 microM) significantly blocked IBMX-induced melanogenesis, but did not induce the inhibitory activity of cell growth. Among them, 2,3-epoxyjuanislamin exhibited a potent inhibitory effect on melanogenesis. Treatment of B16 cells with 2,3-epoxyjuanislamin elicited significant decreases in tyrosinase protein and mRNA levels. These results demonstrated that the inhibitory effects of sesquiterpene lactones on melanin biosynthesis may be due to the suppression of tyrosinase expression.
Activation of PPARβ/δ Causes a Psoriasis-Like Skin Disease In Vivo (2010)

Activation of PPARbeta/delta in the epidermis is sufficient to trigger inflammatory changes, immune activation, and signalling, and gene dysregulation characteristic of psoriasis.