gebhart/patrepeval huggingface dataset:
Time Trends in Severe Head Injuries Among Elderly Finns (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A peek into the future (2013)

Content popularity prediction finds application in many areas, including media advertising, content caching, movie revenue estimation, traffic management and macro-economic trends forecasting, to name a few. However, predicting this popularity is difficult due to, among others, the effects of external phenomena, the influence of context such as locality and relevance to users,and the difficulty of forecasting information cascades.
Temporal dynamics and degradation activity of an bacterial inoculum for treating waste metal‐working fluid (2004)

In order for established bioreactors to be effective for treating chemically mixed wastes such as metal working fluids (MWF) it is essential that they harbour microbial populations that can maintain sufficient active biomass and degrade each of the chemical constituents present. In this study we investigated the effectiveness of a bacterial consortium composed of four species (Clavibacter michiganensis, Methylobacterium mesophilicum, Rhodococcus erythropolis and Pseudomonas putida), assembled on the basis of their apparent ubiquity in waste MWF, degradation ability and tolerance to fluctuating chemistry of the waste. The temporal dynamics of the inoculum and its effects on the fate of individual chemical components of the waste were studied, by regular sampling, over 400 h. Using a complementary approach of culture with chemotaxonomic (FAME) analysis and applying group specific probes (FISH), the inoculum was found to represent a significant component of the community in bioreactors with and without presence of indigenous MWF populations. In addition, the reduction in the COD by the consortium was approximately 85% of the total pollution load, and 30-40% more effectively than any other treatment (indigenous MWF community alone or activated sludge). Furthermore, all the chemical constituents, including the biocide (a formaldehyde release agent) demonstrated > 60% reduction. Many chemical components of the MWF proved to be recalcitrant in the other treatments. The results of this study confirm that assemblage of an inoculum, based on a comprehensive knowledge of the indigenous microbial community, in the target habitat, is a highly effective way of selecting microbial populations for bioaugmentation of bioreactors.
ULTRA-LIGHTWEIGHT CEMENT (2001)

The objective of this project is to develop an improved ultra-lightweight cement using ultra-lightweight hollow glass spheres (ULHS). Work reported herein addresses Task 1: Assess Ultra-Lightweight Cementing Issues, Task 2: Review Russian Ultra-Lightweight Cement Literature, Task 3: Test Ultra-Lightweight Cements, and Task 8: Develop Field ULHS Cement Blending and Mixing Techniques. Results reported this quarter include: preliminary findings from a literature review focusing on problems associated with ultra-lightweight cements; summary of pertinent information from Russian ultra-lightweight cement literature review; laboratory tests comparing ULHS slurries to foamed slurries and sodium silicate slurries for two different applications; and initial laboratory studies with ULHS in preparation for a field job.
Image Quality Considerations In Transform Coding (1985)

A review of adaptive image transform coding techniques is given. Adaptive techniques are superior to nonadaptive procedures; however, their implementation requires a significant degree of added complexity. A major aspect of adaptive transform coding is the understanding and utilization of the local statistical structure of the image. Rate adaptive communication and buffer feedback are also important aspects of adaptive coding procedures. The discussion emphasizes the image quality aspect of the coding process.
Distribution System Modeling and Analysis (2001)

For decades, distribution engineers did not have the sophisticated tools developed for analyzing transmission systems-often they had only their instincts. Things have changed, and we now have computer programs that allow engineers to simulate, analyze, and optimize distribution systems. Powerful as these programs are, however, without a real unders
Intelligent infusion (2009)

In Brief Wireless I.V. pumps allow for remote device management, monitoring of medication administration practices, prompt intervention of medication errors, and timely clinical education regarding near misses.
Operating Room Environment (1999)

Sepsis after total joint replacement is related directly to environmental contamination. Therefore, to control the source of environmental contamination, and ultimately sepsis, it must be realized that the operating room personnel are the major source of the bacteria as evidence by the rise in the colony forming units per square foot per hour from 13 units in an operating room without people to greater than 400 units during actual surgery. The use of inclusive gowns, such as hooded body exhaust, is most helpful. However, all operating room personnel including anesthesia personnel, circulating nurses, visitors, and the operating room team must wear inclusive gowns. Face masks and head covers offer no environmental protection. Some type of an environmental control, such as laminar airflow or ultraviolet light, is the most helpful with greater than 90% reduction of airborne bacteria at the wound and 60% reduction of airborne bacteria in the operating room. Therefore, to reduce environmental bacteria contamination the number of personnel in the operating room and the length of time for the actual surgery should be reduced, because wound contamination occurs first by direct fall out from the environment and second by contaminated equipment and gloved hands that initially were contaminated by the environment.
Fuzzy logic control of a teleoperated log loader machine (2002)

In nonautomated unstructured environments, a machine such as a hydraulic log loader has no model of either itself or the world, and the operator has to control it at a joint-mode level. The operator can be more productive by controlling the machine in task coordinates, whereby the implement direction and speed are first decided by the deflection of a 3D joystick handle. Then, the appropriate control signals to the hydraulic actuators are determined by a computer control system. In this article the application of fuzzy logic to the development of a real-time hydraulic positioning control system for such machines is demonstrated. The control requirements of hydraulic actuation are met by development of (i) a PD-type fuzzy controller with simple set of membership functions and specialized rules and, (ii) a novel offset compensator for removing the steady-state regulating and tracking errors. Experimental results, performed on a Caterpillar 215B-based log loader, are presented.
Radio frequency excited CO2 waveguide lasers (1984)

This paper reports on the operation of radio frequency (rf) excited carbon dioxide waveguide lasers. An efficiency of greater than 10% has been achieved with a maximum power of 21 W. The effects of bore size, waveguide fabrication techniques, and gas mixture are discussed.
Purification, immobilization, and biochemical characterization of <scp>l</scp>‐arginine deiminase from thermophilic <i>Aspergillus fumigatus</i><scp>KJ</scp>434941: Anticancer activity <i>in vitro</i> (2015)

l-Arginine deiminase (ADI) has a powerful anticancer activity against various tumors, via arginine depletion, arresting the cell cycle at G1 phase. However, the current clinically tried bacterial ADI displayed a higher antigenicity and lower thermal stability. Thus, our objective was to purify and characterize this enzyme from thermophilic fungi, to explore its catalytic and antigenic properties for therapeutic uses. ADI was purified from thermophilic Aspergillus fumigatus KJ434941 to its electrophoretic homogeneity by 5.1-fold, with molecular subunit 50 kDa. The purified ADI was PEGylated and covalently immobilized on dextran to explore its catalytic properties. The specific activity of free ADI, PEG-ADI, and Dex-ADI was 26.7, 21.5, and 18.0 U/mg, respectively. At 50°C, PEG-ADI displays twofold resistance to thermal denaturation (t1/2 13.9 h), than free ADI (t1/2 6.9 h), while at 70°C, the thermal stability of PEG-ADI was increased by 1.7-fold, with similar stability to Dex-ADI with the free one. Kinetically, free ADI had the higher catalytic affinity to arginine, followed by PEG-ADI and Dex-ADI. Upon proteolysis for 30 min, the residual activity of native ADI, PEG-ADI, and Dex-AD was 8.0, 32.0, and 20.0% for proteinase K and 10.0, 52.0, and 90.0% for acid protease, respectively. The anticancer activity of the ADIs was assessed against HCT, HEP-G2, and MCF7, in vitro. The free and PEG-ADI exhibits a similar cytotoxic efficacy for the tested cells, lower than Dex-ADI. The free ADI had IC50 value 22.0, 16.6, and 13.9 U/mL, while Dex-ADI had 3.98, 5.18, and 4.43 U/mL for HCT, MCF7, and HEPG-2, respectively. The in vitro anticancer activity of ADI against HCT, MCF7, and HEPG-2 was increased by five-, three-, and threefold upon covalent modification by dextran. The biochemical and hematological parameters of the experimented animals were not affected by ADIs dosing, with no signs of anti-ADI immunoglobulins in vivo. The in vivo half-life time of free ADI, PEG-ADI, and Dex-ADI was 29.7, 91.1, 59.6 h, respectively. The present findings explored a novel thermostable, less antigenic ADI from thermophilic A. fumigatus, with further molecular and crystallographic analyses, this enzyme will be a powerful candidate for clinical trials.
Antihypertensive Angiotensin I-Converting Enzyme Inhibitory Activity and Antioxidant Activity of<i>Vitis</i>hybrid-<i>Vitis coignetiae</i>Red Wine Made with<i>Saccharomyces cerevisiae</i> (2011)

A Vitis hybrid-Vitis coignetiae red wine was vinified by fermentation of a mixture of a Vitis hybrid-Vitis coignetiae must with Saccharomyces cerevisiae KCTC 7904 at 25℃ for 10 days. The Vitis hybrid-Vitis coignetiae red wine showed high antihypertensive angiotensin I-converting enzyme (ACE) inhibitory activity (67.8%) and antioxidant activity (76.7%). The antihypertensive ACE inhibitor in the Vitis hybrid-Vitis coignetiae red wine was partially purified by solid phase extraction chromatography, and its ACE inhibitory activity yielded an IC(50) of 1.8 mg/mL. Six kinds of oligopeptides, including five new kinds, were contained in the partially purified ACE inhibitor fraction from the red wine after 10 days of fermentation. Antioxidant activity decreased significantly from 76.7% to 40.5% when the post-fermentation period was prolonged to 30 days.
Two HIV-1 Epidemics in Argentina: Different Genetic Subtypes Associated With Different Risk Groups (2002)

Summary: This study determined the risk behaviors and viral subtypes of HIV-1 found in 134 heterosexual HIV-seroprevalent maternity patients, 41 of their sexual partners (men who have sex with women [MSW]), and 95 homosexual men (men who have sex with men [MSM]) from Buenos Aires, Argentina. Peripheral blood mononuclear cells (PBMCs) were purified from blood and used for DNA extraction, amplification, and genotyping by the envelope heteroduplex mobility assay (env HMA). Most of the women had been infected by having sex with an already infected partner (84%), whereas most of the male partners had been infected via drug use (76%). Both the patients and their sexual partners were poorly educated, only 30% having completed secondary school. The MSM study subjects, however, were significantly better educated and had a lower prevalence of injecting drug use. Env HMA subtype F was found in 77% (103 of 134) of the maternity patients, with similar rates in their partners (73%). Most of the remaining samples were env subtype B. All but one of the couples was concordant in subtype. In the MSM risk group, however, only 10% were env HMA subtype F. Ninety percent of the MSM samples were subtype B. There are at least two independent epidemics of HIV-1 infection in Buenos Aires, Argentina. One, in heterosexual men and women, is dominated by env subtype F whereas the other, in homosexual men, is dominated by env subtype B, as determined by env HMA.
Controllable Synthesis of TiO2@Fe2O3 Core-Shell Nanotube Arrays with Double-Wall Coating as Superb Lithium-Ion Battery Anodes (2017)

Highlighted by the safe operation and stable performances, titanium oxides (TiO<sub>2</sub>) are deemed as promising candidates for next generation lithium-ion batteries (LIBs). However, the pervasively low capacity is casting shadow on desirable electrochemical behaviors and obscuring their practical applications. In this work, we reported a unique template-assisted and two-step atomic layer deposition (ALD) method to achieve TiO<sub>2</sub>@Fe<sub>2</sub>O<sub>3</sub> core-shell nanotube arrays with hollow interior and double-wall coating. The as-prepared architecture combines both merits of the high specific capacity of Fe<sub>2</sub>O<sub>3</sub> and structural stability of TiO<sub>2</sub> backbone. Owing to the nanotubular structural advantages integrating facile strain relaxation as well as rapid ion and electron transport, the TiO<sub>2</sub>@Fe<sub>2</sub>O<sub>3</sub> nanotube arrays with a high mass loading of Fe<sub>2</sub>O<sub>3</sub> attained desirable capacity of ~520 mA h g<sup>-1</sup>, exhibiting both good rate capability under uprated current density of 10 A g<sup>-1</sup> and especially enhanced cycle stability (~450 mA h g<sup>-1</sup> after 600 cycles), outclassing most reported TiO<sub>2</sub>@metal oxide composites. The results not only provide a new avenue for hybrid core-shell nanotube formation, but also offer an insight for rational design of advanced electrode materials for LIBs.
Supercritical Fluid Processing of Graphene and Graphene Oxide (2011)

Graphene which is single or few atomic layer carbon atoms in a hexagonal network is emerging as a leader among the 2D nanoscale materials [1]. Structurally, graphene is free of defects, with all the carbon atoms linked together by strong and flexible bonds. This has made graphene to have unusual electronic, optical, mechanical and thermal properties. The outstanding properties of graphene reported so far includes Young’s modulus (~1100Gpa), fracture strength (125 Gpa), high thermal conductivity (~ 5000 W m-1K-1), quantum Hall effect at room temperature [2–4], an ambipolar electric field effect along with ballistic conduction of charge carriers [5], tunable band gap and so on. Many efforts have been made on the preparation of the graphene via a number of physical and chemical methods. Some of these methods provides high quality graphene and has opened up new possible routes to address the challenges in preparation and molecular engineering of high quality processable graphene at low cost and large scale [4]. In spite of this progress, the standard procedure to make the high quality graphene is micromechanical cleavage method, which is suitable for only fundamental studies [3]. Alternatively, selective epitaxial growth of graphene on metal or nonmetal substrates using chemical vapor deposition or by thermal decomposition of SiC was developed [6]. The graphene-type carbon materials have been produced by substrate free CVD and radio-frequency plasma-enhanced CVD and so on [7]. On the other hand, the chemical routes are widely considered as a promising approach for large scale production [8]. This approach provides processable graphene, that can be easily cast into various structures or integrate graphene with other materials to form nanocomposites [8, 9]. Currently, there are two most popular chemical approaches to obtain graphene: dispersion and exfoliation of graphite/graphene oxide/graphite intercalation compounds and its reduction after exfoliation or direct exfoliation without chemical modification in suitable organic solvents or surfactants [8]. Unlike the direct exfoliation approach, the chemical modification method results in considerable destruction of graphene electronic structure, thus compromising its unique properties [10, 11]. In addition, these methods involve several steps and need 3-5 days to allow the intercalants and organic solvents to fully insert into the graphitic layers [12]. In contrast to this oxidation and reduction method, some people have developed direct graphite exfoliation method using suitable organic solvent. A high quality single layer graphene sheets (GS) have been prepared by the chemical solution process in which graphite was directly exfoliated in an organic solvent such as N-methylpyrrolidone (NMP)
Perforation Cluster Efficiency of Cemented Plug and Perf Limited Entry Completions; Insights from Fiber Optics Diagnostics (2016)

Abstract It is now well established that the production from horizontal wells completed via hydraulic fracture stimulations (fracs) is highly variable along the length of the wellbore. In addition to subsurface conditions, elements of the completion design, such as fluid volume, proppant tonnage, rate, stage length, the number of perforation clusters and their spacing, influence the performance of individual stimulated intervals and wells. Information about completion efficiency can be obtained using Fiber Optic (FO) diagnostics. Distributed Temperature Sensing (DTS) and Distributed Acoustic Sensing (DAS) provide great insights into the factors controlling frac construction and performance of each perforation cluster. The integrated analysis of DAS and DTS in horizontal wells completed with multiple perforation clusters per stage indicate that, although most perforation clusters receive fluids during the stimulation, there are significant changes in efficiency during the frac stimulation process that can impact frac connectivity, conductivity and ultimately, their production. This presentation illustrates recent observations about Perforation Cluster Efficiency (PCE) using FO diagnostics and summarizes the results for many wells with Cemented Plug and Perforated completions Limited Entry design (CPnP LE).
The Expression of Fascin, an Actin-Bundling Motility Protein, Correlates with Hormone Receptor–Negative Breast Cancer and a More Aggressive Clinical Course (2005)

The invasion and metastasis of tumor cells is a major cause of mortality in cancer patients. In the current study, we investigated the expression of fascin, an actin-bundling motility-associated protein, in 210 invasive breast carcinomas with corresponding 5-year clinical follow-up. Fascin expression was compared with hormone receptor (ER/PR) status, HER2 status, cancer grade, cancer stage, metastasis pattern, disease-free survival, and overall survival. Fascin expression was seen in 16% (33/210) of the cases and correlated with ER negativity (22/33, P < 0.001), PR negativity (21/33, P < 0.001), Bloom-Richardson grade 3 (19/29, P < 0.001), and advanced stage (stage 3 or 4, P = 0.04). There was no correlation between fascin expression and HER2 status or pattern of metastases. Patients whose tumors were positive for fascin showed both a decreased mean disease-free survival (74.44 versus 100.52 months, P = 0.002) and mean overall survival (77.58 versus 98.98 months, P = 0.002), independent of tumor stage and HER2 status, but not independent of ER/PR status or cancer grade. Given fascin's role in altering cell motility, overexpression may contribute to a more aggressive clinical course in ER/PR-negative breast cancers. If so, then fascin may represent a new molecular target for therapeutic intervention in patients with ER-negative breast cancer.
C<sub>60</sub> derivatives embedded in sol‐gel silica films (1995)

Trasparent sol‐gel thin films and monoliths containing fullerene derivatives (e.g. see Figure) are reported. The sol‐gel technique provides a low‐temperature method to poduce homogeneous thin films and preliminary measurements reveal that these new commposite materials, the first sol‐gel materials to contain C 60 or its derivatives, exhibit interesting optical limiting properties. magnified image
Effects of a Hydroxyapatite-based Biomaterial on Gene Expression in Osteoblast-like Cells (2006)

Biostite is a hydroxyapatite-derived biomaterial that is used in periodontal and bone reconstructive procedures due to its osteoconductive properties. Since the molecular effects of this biomaterial on osteoblasts are still unknown, we decided to assess whether it may specifically modulate osteoblast functions in vitro. We found that a brief exposure to Biostite significantly reduced the proliferation of MG-63 and SaOS-2 osteoblast-like cells to approximately 50% of the plateau value. Furthermore, gene array analysis of MG-63 cells showed that Biostite caused a differential expression of 37 genes which are involved in cell proliferation and interaction, and related to osteoblast differentiation and tissue regeneration. Results were confirmed by RT-PCR, Western blot, and by an increase in alkaline phosphatase (ALP) specific activity. Biostite also increased levels of polycystin-2, a mechano-sensitive Ca(2+) channel, a promising new marker of bone cell differentiation. Biostite, therefore, may directly affect osteoblasts by enhancing chondro/osteogenic gene expression and cytoskeleton-related signaling pathways, which may contribute to its clinical efficacy.
Purification and in vitro phosphorylation of HupT, a regulatory protein controlling hydrogenase gene expression in Rhodobacter capsulatus (1997)

The HupT protein of Rhodobacter capsulatus, involved in negative regulation of hydrogenase gene expression, is predicted to be a histidine kinase on the basis of sequence comparisons. The protein was overproduced in Escherichia coli, purified to homogeneity, and demonstrated to autophosphorylate in vitro in the presence of [gamma-32P]ATP. An H217N hupt mutant was constructed, and the mutant protein was shown to have lost kinase activity. This result, and the fact that the phosphoryl group in phosphorylated HupT appeared to be bound to an N atom, support the suggestion from sequence comparisons that HupT is a histidine kinase, which can autophosphorylate on the His217 residue.