gebhart/patrepeval huggingface dataset:
Metal-free click polymerization of propiolates and azides: facile synthesis of functional poly(aroxycarbonyltriazole)s (2012)

.Azide-alkyne click polymerization is generally catalyzed by the Cu(I) complex, in which the removal of metallic residues after reaction remains challengeable. In this work, a metal-free click polymerization method was developed to avoid this problem. The diazide monomers (9 and 10) could readily react with aromatic and aliphatic dipropiolates (1 and 2) under simple heating to produce functional poly(aroxycarbonyltriazole)s (PACTs), a kind of polyester, with high molecular weights (M-w up to 23 500) and regioregularities (fraction of 1,4-disubstituted 1,2,3-triazole in polymers up to similar to 90%) in excellent yields (up to similar to 99%). The metal-free click polymerization also propagates smoothly in an open atmosphere without protection from oxygen and moisture. The PACTs are thermally stable, with 5% loss of their weights at temperatures higher than 335 degrees C. Thanks to the contained ester groups, the polymers can be rapidly degraded in the presence of potassium hydroxide aqueous solution. The PACT containing tetraphenylethene units exhibits a unique feature of aggregation-induced emission and can function as a fluorescent chemosensor to detect explosives in a superamplified manner.
IGBT-bipolar discrete Darlington power switches: performance and design (2002)

An IGBT (insulated-gate bipolar transistor)-bipolar discrete Darlington power switch is presented. The main high-current bipolar power switch is driven by a lower current IGBT, yielding a switch with low drive requirements and high current handling capacity. The power dissipation is lower than that of a MOS-bipolar Darlington. The behavior of such a switch is investigated using discrete device models and an important parasitic network. Some of the important design parameters of the switch and drive circuit are discussed together with possible ways of improving circuit performance. Some aspects of protection and paralleling are also presented. The analysis and discussions are supported by oscillograms from laboratory experiments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Superparamagnetic iron oxide nanoparticles for<i>in vivo</i>molecular and cellular imaging (2015)

In the last decade, the biomedical applications of nanoparticles (NPs) (e.g. cell tracking, biosensing, magnetic resonance imaging (MRI), targeted drug delivery, and tissue engineering) have been increasingly developed. Among the various NP types, superparamagnetic iron oxide NPs (SPIONs) have attracted considerable attention for early detection of diseases due to their specific physicochemical properties and their molecular imaging capabilities. A comprehensive review is presented on the recent advances in the development of in vitro and in vivo SPION applications for molecular imaging, along with opportunities and challenges.
Adaptive Impedance-Matching Techniques for Controlling<i>L</i>Networks (2009)

The link quality of mobile phones suffers from antenna mismatch due to fluctuating body effects. Techniques for adaptive control of impedance-matching <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">L</i> networks are presented, which provide automatic compensation of antenna mismatch. To secure reliable convergence, a cascade of two control loops is proposed for independent control of the real and imaginary parts of impedance. A secondary feedback path is used to enforce operation into a stable region when needed. These techniques exploit the basic properties of tunable series and parallel <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LC</i> networks. A generic quadrature detector that offers a power-independent orthogonal reading of the complex impedance value is presented, which is used for direct control of variable capacitors. This approach renders calibration and elaborate software computation superfluous and allows for autonomous operation of adaptive antenna-matching modules.
Purification and properties of glucosyltransferase responsible for water-insoluble glucan synthesis from Streptococcus mutans (1982)

A glucosyltransferase responsible for water-insoluble glucan synthesis was purified from the culture fluids of Streptococcus mutans 6715-15 strain by column chromatography on Toyopearl HW-60 and subsequently on hydroxyapatite. The enzyme preparation gave a single band on analysis by polyacrylamide gel electrophoresis. The pH dependency of the activity showed two optimal peaks at 5.8 and 7.3 and the Km values for sucrose were 1.4 and 3.3 mM at the respective optimal pHs. The molecular weight determined by sodium dodecyl sulfate gel electrophoresis was 180,000. Although the enzyme scarcely synthesized water-insoluble and water-soluble glucans from sucrose, water-insoluble glucan formed from sucrose in the presence of dextran T10 consisted of over 93% alpha-1, 3-glucosidic linkage. Analysis of the structure of water-insoluble glucan indicated that the enzyme catalyzed the formation of branch points in alpha-1,6-glucan (dextran) and transferred the glucosyl moiety of sucrose to the C-3 position of the branching glucose residue of dextran. Since this enzyme has not yet been registered, we named it mutansynthetase (EC 2.4.1.?).
Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study (2017)

This study was registered prospectively with Clinicaltrials.gov , number NCT00833417 on January 30, 2009.
60 GHz WPAN Standardization within IEEE 802.15.3c (2007)

WPAN properties are defined and the present IEEE 802.15.3, 2.4 GHz WPAN standard is briefly outlined. 60 GHz WPAN applications and environments are presented. Presently available low-cost 60 GHz semiconductor integrated circuits are shown. Millimeter wave frequency bands and Regulatory bodies are discussed. Finally, a chronology of 60 GHz WPAN standardization activity is presented.
Regioselective Cleavage of Myoglobin with Copper(II) Compounds at Neutral pH (2002)

Selective hydrolytic cleavage of myoglobin was studied with CuCl2, Cu(ClO4)2, Cu(AC)2, and binuclear Cu(II) complexes of 3,6,9,16,19,22-hexaaza-6,19-bis (2-hydroxyethyl)-tricyclo- [22,2,2,2(11,14)]-triaconta-1,11,13,24,27,29-hexaene (1) and 3,6,9,16,19,22-hexaaza-tricyclo-[22,2,2,2(11,14)]-triaconta- 1,11,13,24,27,29-hexaene (2). The sites of cleavage were precisely determined by LC-ESIMS and further confirmed by an MS/MS method through fragmentation from both the N-terminal and C-terminal. The peptide bonds of Gln91-Ser92 and Ala94-Thr95 were remarkably cleaved by Cu(II) anchored to the side chain of the His93 residue. The data presented in this study show that Cu(II)-mediated cleavage of myoglobin is able to proceed at neutral pH, more selectively than Pd(II)-mediated cleavage, and buffer solution of phosphate and NH4HCO3 accelerates the cleavage reaction.
Time-Domain Transmitting Boundary Condition in Fluid-Structure Interaction Studies (1991)

One of the major difficulties in the nonlinear analyses of fluid-structure interactions has been the lack of exact expressions for the transmitting boundary in the time domain. Researchers in the past have adopted the Sommerfeld radiation condition (1912) in their calculations using the assumption that the outgoing waves are nearly planes at large distance from the disturbance. This assumption was used by many for many years. However, no assessment has been made regarding its suitability and accuracy. In 1990 the authors have advanced an exact time-domain transmitting boundary condition for fluid-structure interaction problems. In this paper comparisons of results are made by using the Sommerfeld radiation condition and by using the exact solution for the fluid transmitting boundary. It will be shown that there exists significant differences in results by using these two approaches, and that the exact transmitting boundary condition yields considerably more accurate results in cases when exact solutions are known.
Stem cells and molecular strategies to restore hearing. (2008)

Hearing loss is a costly and growing problem for the elderly population worldwide with millions of people being affected. There are currently two prosthetic devices available to minimize problems associated with the two forms of hearing loss: hearing aids that amplify sound to overcome middle ear based conductive hearing loss and cochlear implants that restore some hearing after neurosensory hearing loss. The current presentation provides information on the treatment of neurosensory hearing loss. Although the cochlear implant solution for neurosensory hearing loss is technologically advanced; it still provides only moderate hearing capacity in neurosensory deaf individuals. Inducible stem cells and molecular therapies are appealing alternatives to the cochlear implant and may provide more than a new form of treatment as they hold the promise for a cure. To this end, current insights into inducible stem cells that may provide cells for seeding the cochlea with the hope of new hair cell formation are being reviewed. Alternatively, similar to induction of stem cells, cells of the flat epithelium that remains after hair cell loss could be induced to proliferate and differentiate into hair cells. In either of these strategies, hair cell specific genes known to be essential for hair cell differentiation or maintenance such as ATOH1, POU4F3, GFI1, and miRNA-183 will be utilized with the hope of completely restoring hearing to all patients with hearing loss.
Deoxydehydration of glycerol to allyl alcohol catalyzed by rhenium derivatives (2014)

Both ReO<sub>3</sub> and methyltrioxorhenium combined with alcohol reductants are used for the efficient deoxydehydration of glycerol to allyl alcohol.
Repetitive Zn2+-binding domains in the protein transcription factor IIIA from <i>Xenopus</i> oocytes (1986)

Conference Article| April 01 1986 Repetitive Zn2+-binding domains in the protein transcription factor IIIA from Xenopus oocytes A. KLUG; A. KLUG 1M.R.C. Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, U.K. Search for other works by this author on: This Site PubMed Google Scholar J. MILLER; J. MILLER 1M.R.C. Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, U.K. Search for other works by this author on: This Site PubMed Google Scholar A. D. McLACHLAN A. D. McLACHLAN 1M.R.C. Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1986) 14 (2): 221. https://doi.org/10.1042/bst0140221a Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation A. KLUG, J. MILLER, A. D. McLACHLAN; Repetitive Zn2+-binding domains in the protein transcription factor IIIA from Xenopus oocytes. Biochem Soc Trans 1 April 1986; 14 (2): 221. doi: https://doi.org/10.1042/bst0140221a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1986 Biochemical Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.
Novel approach to evaluating breast density utilizing ultrasound tomography (2007)

Women with high mammographic breast density have a four- to fivefold increased risk of developing breast cancer compared to women with fatty breasts. Many preventative strategies have attempted to correlate changes in breast density with response to interventions including drugs and diet. The purpose of this work is to investigate the feasibility of assessing breast density with acoustic velocity measurements with ultrasound tomography, and to compare the results with existing measures of mammographic breast density. An anthropomorphic breast tissue phantom was first imaged with our computed ultrasound tomography clinical prototype. Strong positive correlations were observed between sound speed and material density, and sound speed and computed tomography number (Pearson correlation coefficients= 0.87 and 0.91, respectively). A cohort of 48 women was then imaged. Whole breast acoustic velocity was determined by creating image stacks and evaluating the sound speed frequency distribution. The acoustic measures of breast density were evaluated by comparing these results to two mammographic density measures: (1) qualitative estimates determined by a certified radiologist using the BI-RADS Categorical Assessment based on a 1 (fatty) to 4 (dense) scale, and (2) quantitative measurements via digitization and computerized analysis of archival mammograms. A one-way analysis of variance showed that a significant difference existed between the mean values of sound speed according to BI-RADS category, while post hoc analyses using the Scheffé criterion for significance indicated that BI-RADS 4 (dense) patients had a significantly higher sound speed than BI-RADS 1, 2, and 3 at an alpha level of 0.05. Using quantitative measures of breast density, a direct correlation between the mean acoustic velocity and calculated mammographic percent breast density was demonstrated with correlation coefficients ranging from 0.75 to 0.89. The results presented here support the hypothesis that sound speed can be used as an indicator of breast tissue density. Noninvasive, nonionizing monitoring of dietary and chemoprevention interventions that affect breast density are now possible.
Properties of Radiophotoluminescent Glass Dosemeter Systems Using Pulsed Laser UV Excitation (1986)

Abstract The UV pulsed laser excitation of PL glasses has been investigated using the new Toshiba reader FGD-8 and flat FD-7 glasses of size 16x16x1.5 mm3. In comparison with the conventional UV excitation with mercury lamps, the nitrogen laser excitation decreases the pre-dose Ho by a factor of 100 to about 10 µSv. Glass cleaning is no longer necessary. The main parameters studied were the empirical standard deviation s(H) relative to dose, the total random uncertainty sR(H) with dose, and the lowest detectable dose HLDL has been found to be 30 µSv and 7 µSv for 10 laser pulses and 200 laser pulses per readout. For a dose equivalent &gt;1 mSv the relative s-value is &lt;1%. The photon energy dependence of flat glass dosemeters for the indication of Hp(10) is ±13% in the energy range 15 keV - 1.2 MeV. In combination with an automatic readout still in development at Toshiba the RPL system will in future be attractive for a large scale use in personal and environmental monitoring.
Using Term Extraction Patterns to Discover Coherent Relationships from Open Source Intelligence (2010)

Unstructured open source information, especially the social, political, economic and cultural events described within web-based text/news articles, often contain possible motives for cyber security and trust issues. Automated processing of numerous open source intelligence sources requires the discovery of key domain terms, their conceptual hierarchies and the coherent relationships among them. A syntactic analysis of the word sequences in unstructured text documents allows for the extraction of subject-predicate-object triples, which form the basis for Term Extraction Patterns (TEP). In our research, we use TEPs to discover domain-specific multi-word entities which in turn, can be arranged in a taxonomy based on their semiotic inter-relationships. We explore the use of this method within the cyber security domain and analyze a collection of related news articles gathered from various public web sources. In this paper our initial results of term extraction and the semantic coherence derived from the TEP analyses are described. Our work extends beyond current methods, and our contribution is a novel methodology to extract semantics from unstructured text in domain specific open source information and its application to predict cyber attack outbreaks.
Heterogeneous Multi-task Learning for Human Pose Estimation with Deep Convolutional Neural Network (2014)

We propose an heterogeneous multi-task learning framework for human pose estimation from monocular image with deep convolutional neural network. In particular, we simultaneously learn a pose-joint regressor and a sliding-window body-part detector in a deep network architecture. We show that including the body-part detection task helps to regularize the network, directing it to converge to a good solution. We report competitive and state-of-art results on several data sets. We also empirically show that the learned neurons in the middle layer of our network are tuned to localized body parts.
Skip Techniques for High-Speed Carry-Propagation in Binary Arithmetic Units (1961)

After a very brief summary of the various well-known methods of expediting carry-propagation in binary arithmetic units, the paper discusses and develops the ``anticipated-carry'' or ``carry-skip'' technique originally due in decimal form to Babbage, much used in mechanical calculators and lately revived for use in binary units. Various degrees of refinement are possible. It appears that for a given expenditure, the technique results in a unit which is simpler and faster than those using one of the other techniques. Conversely in order to attain a given speed with given circuit elements, the skip technique appears to minimize the equipment requirement among the known speed-up techniques.
Interactive Decision Support for Requirements Negotiation (1994)

The concurrent engineering approach calls for the simultaneous consideration of a variety of concerns from a variety of perspectives When a team is provided proper tools, such multi-faceted analysis can reduce many common oversights early in the design process However, issues common to all group interactions can hinder a concurrent engineering team. We present research which supports concurrent engineering teamwork during the initial, requirement, and specification stages of system design.
Reality-based generation of virtual environments for digital earth (2008)

Abstract Digital Earth essentially consists of 3D and moreD models and attached semantic information (attributes). Techniques for generating such models efficiently are required very urgently. Reality-based 3D modelling using images as prime data source plays an important role in this context. Images contain a wealth of information that can be advantageously used for model generation. Images are increasingly available from satellite, aerial and terrestrial platforms. This contribution briefly describes some of the problems which we encounter if the process of model generation is to be automatised. With the help of some examples from Digital Terrain Model generation, Cultural Heritage and 3D city modelling we show briefly what can be achieved. Special attention is directed towards the use of model helicopters for image data acquisition. Some problems with interactive visualisation are discussed. Also, issues surrounding R&D, professional practice and education are also addressed.
Design and performance of a novel powder flash evaporator (1993)

We have designed a high vacuum powder flash evaporator source with potential for ultrahigh vacuum applications. The powder is transported to the resistance-heated boat inside a sloping, vibrating, tube. The evaporator is novel in that the transport tube is driven by a piezoelectric motor connected to a low-power frequency generator. When loaded with powder ground from single crystals of NaI(Tl), the evaporator has been successfully used to create 25-μm-thick films of NaI(Tl) having homogeneous thallium concentrations. The powder feeder is inexpensive in comparison to other vapor sources (sputter, e beam, wire feed, etc.) typically used to deposit alloys and impure materials. This paper discusses the design and application of the flash evaporator.
Silicon production in a fluidized bed reactor (1986)

Part of the development effort of the JPL in-house technology involved in the Flat-Plate Solar Array (FSA) Project was the investigation of a low-cost process to produce semiconductor-grade silicon for terrestrial photovoltaic cell applications. The process selected was based on pyrolysis of silane in a fluidized-bed reactor (FBR). Following initial investigations involving 1- and 2-in. diameter reactors, a 6-in. diameter, engineering-scale FBR was constructed to establish reactor performance, mechanism of silicon deposition, product morphology, and product purity. The overall mass balance for all experiments indicates that more than 90% of the total silicon fed into the reactor is deposited on silicon seed particles and the remaining 10% becomes elutriated fines. Silicon production rates were demonstrated of 1.5 kg/h at 30% silane concentration and 3.5 kg/h at 80% silane concentration. The mechanism of silicon deposition is described by a six-path process: heterogeneous deposition, homogeneous decomposition, coalescence, coagulation, scavenging, and heterogeneous growth on fines. The bulk of the growth silicon layer appears to be made up of small diameter particles. This product morphology lends support to the concept of the scavenging of homogeneously nucleated silicon.
Binding of Clozapine Metabolites and Analogues to the Histamine H<sub>3</sub> Receptor in Rat Brain Cortex (1996)

Following up the finding that the non-imidazole drug clozapine shows a considerable histamine H3 receptor antagonistic activity, a series of analogues and metabolites (clozapine-N-oxide, and N-desmethylclozapine) were tested for their affinity towards the H3 receptor using the radiolabelled H3 antagonist [125I]-iodophenpropit. Qualitative structure affinity relationships are derived for the tested compounds. In the clozapine molecule four structurally different moieties may be considered. In comparison with the affinity for the H3 receptor shown by clozapine, the following main conclusions can be drawn: The 4-piperazinyl region does not allow substituents longer than a CH3 or electronegative atoms such as an O (as in clozapine-N-oxide); the lack of the CH3 group (as in N-desmethylclozapine) also reduces the affinity for H3 receptors. Substitutions at the 5-diazepine position do not drastically alter the affinity for the H3 receptor, although a basic nitrogen is favoured over CH2, O, or S. The 8 position in ring I is an important modulatory site for H3 affinity; electronegative substituents such as chloro and fluoro in this aromatic ring increase the affinity. When these substituents are, however, present at position X2 in the ring, they disable binding to the H3 receptor. The two major clozapine metabolites (clozapine-N-oxide, and N-desmethylclozapine) will not be responsible for a possible contribution of the H3 receptor antagonism to the clinical profile of clozapine.
AN INEXPENSIVE MASKING NOISE GENERATOR: MONAURAL OR STEREO (1965)

ABSTRACT A simple masking noise generator which can be constructed for about thirty five dollars is described. The output is sufficient to drive several pairs of headphones or a loudspeaker in a Skinner box. Duplication of the unit for another twenty five dollars allows “stereo” masking noise to be used on the headphones, a feature which most subjects find more pleasant than monaural masking noise.
ChemInform Abstract: Electrochemically Active Threading Intercalator with High Double Stranded DNA Selectivity. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.