gebhart/patrepeval huggingface dataset:
The learning of control concepts using interactive tools (2005)

This paper discusses the creation of interactive computer simulations that implement virtual laboratories in the field of Control Engineering education. Easy Java Simulations (Ejs, http://fem.um.es/Ejs/), a Java-based tool that helps create interactive dynamic simulations, is introduced. This tool can be used on its own, generating stand-alone Java applications or applets, or in conjunction with Matlab/Simulink, using them as the internal engine that describes and solves the model. We describe in this paper this particular feature in detail, and provide some examples that show the advantages that this tool offers to the world-wide engineering education community. Ejs is a freeware, open source, tool aimed for educators with low profile in programming but deep knowledge on certain technical and scientific fields. The tool allows to develop complete, interactive simulations in three steps: describing the mathematical model (optionally using Matlab/Simulink), building the user interface using off-the-shelf graphical elements, and connecting certain properties of these elements to the variables of the model. This last step is the key point to transform a classical simulation into a full interactive application. © 2005 Wiley Periodicals, Inc. Comput Appl Eng Educ 13: 84–98, 2005; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae.20033
Multiple Exciton Generation in Colloidal Silicon Nanocrystals (2007)

Multiple exciton generation (MEG) is a process whereby multiple electron-hole pairs, or excitons, are produced upon absorption of a single photon in semiconductor nanocrystals (NCs) and represents a promising route to increased solar conversion efficiencies in single-junction photovoltaic cells. We report for the first time MEG yields in colloidal Si NCs using ultrafast transient absorption spectroscopy. We find the threshold photon energy for MEG in 9.5 nm diameter Si NCs (effective band gap identical with Eg = 1.20 eV) to be 2.4 +/- 0.1Eg and find an exciton-production quantum yield of 2.6 +/- 0.2 excitons per absorbed photon at 3.4Eg. While MEG has been previously reported in direct-gap semiconductor NCs of PbSe, PbS, PbTe, CdSe, and InAs, this represents the first report of MEG within indirect-gap semiconductor NCs. Furthermore, MEG is found in relatively large Si NCs (diameter equal to about twice the Bohr radius) such that the confinement energy is not large enough to produce a large blue-shift of the band gap (only 80 meV), but the Coulomb interaction is sufficiently enhanced to produce efficient MEG. Our findings are of particular importance because Si dominates the photovoltaic solar cell industry, presents no problems regarding abundance and accessibility within the Earth's crust, and poses no significant environmental problems regarding toxicity.
Restriction endonuclease DNA analysis of Clostridium difficile (1987)

HindIII restriction enzyme digests of genomic DNA from nine distinct strains of Clostridium difficile were undertaken, and the results were related to those of a previously established typing method based on [35S]methionine-labeled protein profiles. Each of the typed strains identified by its protein profile could also be distinguished by its unique DNA digestion pattern. Analysis of strains isolated from 10 patients during a hospital outbreak of antibiotic-associated colitis revealed identical DNA profiles, confirming a single strain as the source of cross-infection. Characterization of isolates from worldwide sources revealed similar digestion patterns within the same strain type. Restriction endonuclease DNA analysis provides a sensitive and useful technique for studying the epidemiology of C. difficile.
Role of acetate in the reduction of plasma free fatty acids produced by ethanol in man (1968)

To investigate the mechanism by which ethanol lowers plasma free fatty acids, we tested the ability of two products of alcohol metabolism, acetate and lactate, to lower free fatty acids in man. Sodium acetate was given orally to five healthy fasting volunteers and caused a significant fall in plasma free fatty acids. After amounts of ethanol and acetate that produced similar reductions in free fatty acids, plasma acetate increased 3- to 4-fold within 20 min. In each of three subjects the fall of free fatty acids observed after acetate ingestion occurred at plasma acetate levels less than or equal to those reached after ethanol. In all studies plasma glucose remained stable. Oral administration of sodium lactate to another volunteer in amounts sufficient to raise plasma lactate concentrations to a level similar to that found after ethanol administration failed to lower plasma free fatty acids. Thus acetate, a metabolite of ethanol, reduces plasma free fatty acids at plasma acetate levels comparable to those resulting from ethanol metabolism, which suggests that the lowering of plasma free fatty acids produced by ethanol is mediated, at least in part, by acetate.
Evidence That Human Fcγ Receptor IIA (CD32) Subtypes Are Not Receptors for Oxidized LDL (1997)

Several lines of evidence suggest that clearance of oxidized LDL (oxLDL) immune complexes by macrophage IgG Fc receptors (Fc gamma Rs) plays a role in atherogenesis. Ox-LDL may also be cleared directly by Fc gamma Rs, as shown for murine Fc gamma RII-B2. In humans, the homologous Fc gamma R is Fc gamma RIIA (CD32), which is abundantly expressed on monocytes and macrophages and shares 60% sequence identity with murine Fc gamma RII-B2. As murine Fc gamma RII-B2 and human Fc gamma RIIA also share similar IgG ligand-binding properties, the purpose of this study was to test the hypothesis that human CD32 is a receptor for oxLDL. For these studies we used transfected Chinese hamster ovary (CHO) cells, monocytes, and cell lines that functionally express either of two Fc gamma RIIA subtypes (R131 or H131) and assayed binding or degradation of several preparations of oxLDL. The integrity of all oxLDL preparations was checked by studying their ability to react with CHO cells expressing human type I scavenger receptors and by other characteristics of lipoprotein oxidation. Although we showed that each preparation of oxLDL could recognize class A or class B scavenger receptors, we did not detect any differences in the binding or degradation of any type of oxLDL preparation among control versus CHO cell transfectants. Using monocytes that express Fc gamma RIIA and CD36, we showed that the binding of oxLDL was inhibited by antibodies to CD36, but not by Fc gamma RIIA antibodies. Thus, the data do not support the hypothesis that human Fc gamma RIIA is by itself a receptor for oxLDL. We conclude that human CD32 can mediate uptake of lipoprotein immune complexes, but does not mediate uptake of oxLDL in the absence of anti-oxLDL antibodies. OxLDL may interact with human mononuclear phagocytes directly via other types of receptors, such as class A and class B scavenger receptors or CD68.
On constructing the Huffman-code-based reversible variable-length codes (2001)

In this letter, we propose a generic and efficient algorithm that can construct both asymmetrical and symmetrical reversible variable-length codes (RVLCs). Starting from a given Huffman code, the construction is based on two developed codeword selection mechanisms, for the symmetrical case and the asymmetrical case, respectively; it is shown that the two mechanisms possess simple features and can generate efficient RVLCs easily. In addition, two new asymmetrical RVLCs are constructed and shown to be very efficient for further reducing the coding overheads in MPEG-4 when operating in the reversible decoding mode.
DNA sequence compression using the normalized maximum likelihood model for discrete regression (2003)

The use of normalized maximum likelihood (NML) model for encoding sequences known to have regularities in the form of approximate repetitions was discussed. A particular version of the NML model was presented for discrete regression, which was shown to provide a very powerful yet simple model for encoding the approximate repeats in DNA sequences. Combining the model of repeats with a simple first order Markov model, a fast lossless compression method was obtained that compares favorably with the existing DNA compression programs. It is remarkable that a simple model, which recursively updates a small number of parameters, is able to reach the state of the art compression ratio for DNA sequences with much more complex models. Being a minimum description length (MDL) model, the NML model may later prove to be useful in studying global and local features of DNA or possibly of other biological sequences.
A technique for improving tag contrast persistence in SSFP MRI imaging using adaptive flip angle (2005)

Steady state free precession (SSFP) proved to be an efficient fast MR imaging technique due to its short acquisition time and high SNR. Myocardium tagging can be combined with SSFP, so that the deformation of tag lines allows for measurement of myocardial wall motion. However, at later imaging time, the tagging contrast deteriorates, which makes it harder to track the tag lines. We introduce a new technique that adaptively adjusts the flip angle at each RF pulse in order to keep the tagging contrast constant, and hence maintain the tag contrast to noise ratio (Tag-CNR) throughout the imaging period. A computer simulation was done to validate and compare between the tagging contrast with SSFP and that of spoiled gradient echo (SPGR), where the tagging contrast is made constant during the cine sequences in both methods. Preliminary results show potential superiority of SSFP in yielding higher contrast than SPGR.
Personality in Computer Characters (1996)

Several growth factors may stimulate proliferation of thyroid cells. This effect has, in part, been dependent on calcium entry. In the present study using FRTL-5 cells, we show that in addition to its effect on calcium fluxes, ATP acts as a comitogen in these cells. In medium containing 5% serum, but no TSH, ATP stimulated the incorporation of 3H-thymidine in a dose- and time-dependent manner in the cells. At least a 24-h incubation with ATP was necessary to observe the enhanced (30-50%) incorporation of 3H-thymidine and an increased (30%) cell number. The effect of ATP was dependent on insulin in the incubation medium. Furthermore, ATP enhanced the TSH-mediated incorporation of 3H-thymidine. The effect of ATP was apparently mediated via a G-protein dependent mechanism, as no stimulation of thymidine incorporation was observed in cells treated with pertussis toxin. The effect of ATP was not dependent on the activation of protein kinase C (PKC), as ATP was effective in cells with downregulated PKC. ATP rapidly phosphorylated mitogen activated protein (MAP) kinase in FRTL-5 cells. In addition, ATP stimulated the expression of a 62 kDa c-fos dependent protein in a dose- and time-dependent manner. Our results thus suggest that extracellular ATP, in the presence of insulin, may be a cofactor in the regulation of thyroid cell proliferation, probably by phosphorylating MAP kinase and stimulating the expression of c-fos.
Sequence, localization and function of the invasin protein of <i>Yersinia enterocoiitica</i> (1990)

The inv locus of Yersinia enterocolitica is sufficient to convert a non-invasive Escherichia coli K12 strain into a microorganism that is able to penetrate cultured mammalian cells. The nucleotide sequence of inv reveals an open reading frame corresponding to an 835-amino-acid protein that is homologous to the invasin protein from Yersinia pseudotuberculosis. A polyclonal antiserum elicited by a synthetic peptide corresponding to the C-terminal 88 amino acids of this open reading frame detected a unique 100 kD protein in cell lysates of Y. enterocolitica strain 8081 c and in an E. coli strain harbouring the cloned inv gene. This protein localized to the outer membranes of both microorganisms and was cleaved by low concentrations of extracellular trypsin. HEp-2 cells were shown to attach to surfaces coated with bacterial outer membranes containing invasin and this attachment was destroyed by treatment of the membranes with trypsin. Thus it appears that the invasin protein from Y. enterocolitica is able to mediate both attachment to and entry of cultured epithelial cells.
Controlled Fusion and Plasma Physics (2007)

This new book by Kenro Miyamoto provides an up-to-date overview of the status of fusion research and the important parts of the underlying plasma physics at a moment where, due to the start of ITER construction, an important step in fusion research has been made and many new research workers will enter the field. For them, and also for interested graduate students and physicists in other fields, the book provides a good introduction into fusion physics as, on the whole, the presentation of the material is quite appropriate for getting acquainted with the field on the basis of just general knowledge in physics. There is overlap with Miyamoto's earlier book Plasma Physics for Nuclear Fusion (MIT Press, Cambridge, USA, 1989) but only in a few sections on subjects which have not evolved since. The presentation is subdivided into two parts of about equal length. The first part, following a concise survey of the physics basis of thermonuclear fusion and of plasmas in general, covers the various magnetic configurations studied for plasma confinement (tokamak; reversed field pinch; stellarator; mirror-type geometries) and introduces the specific properties of plasmas in these devices. Plasma confinement in tokamaks is treated in particular detail, in compliance with the importance of this field in fusion research. This includes a review of the ITER concept and of the rationale for the choice of ITER's parameters. In the second part, selected topics in fusion plasma physics (macroscopic instabilities; propagation of waves; kinetic effects such as energy transfer between waves and particles including microscopic instabilities as well as plasma heating and current drive; transport phenomena induced by turbulence) are presented systematically. While the emphasis is on displaying the essential physics, deeper theoretical analysis is also provided here. Every chapter is complemented by a few related problems, but only partial hints for their solution are given. A selection of references, mostly to articles covering original research, allows the interested reader to go deeper into the various subjects. There are a few quite relevant areas which are essentially not covered in the book (plasma diagnostics; fuelling). The discussion of particle and power exhaust is limited to tokamaks and is somewhat scarce. Other points which I did not find fully satisfactory are: the index is too selective and does not really allow easy access to any specific subject. Cross references between different sections treating related topics are not always given. There are quite a lot of typographical errors which as far as cross references are concerned may be disturbing. A list of the symbols used would be a helpful supplement, especially since some of them appear with different meanings. There are apparent imperfections in the structure of certain chapters. While the English is sometimes unusual, this generally does not affect the readability. Overall, the book can be warmly recommended to all interested in familiarizing themselves with the physics of magnetic fusion.
Expression of sialyl-Lewis X, an E-selectin ligand, in inflammation, immune processes, and lymphoid tissues. (1992)

The carbohydrate structure sialyl-Lewis X (SLex) can function as a ligand for E-selectin, formerly known as endothelial leukocyte adhesion molecule-1 (ELAM-1). This study was performed to analyze the expression of SLex by leukocytes and other cell types in the context of inflammatory and immune processes. Human peripheral blood cells were examined by flow cytometry using monoclonal antibody CSLEX1 directed against SLex. Cell surface SLex was found in abundance on nearly all isolated polymorphonuclear leukocytes (PMN) and monocytes, and at low levels on a substantial portion (up to 40%) of natural killer cells. This moiety was expressed also on approximately 10% of peripheral blood T cells. Immunohistochemistry was performed on various human tissues involved in inflammatory or immune processes and on secondary lymphoid tissues. In acute appendicitis, endothelial cells of postcapillary venules expressed E-selectin, and most PMN, both within vessels and extravasated, expressed SLex. A substantial number of monocytes/macrophages in inflamed appendiceal, synovial, and dermal tissues also reacted with antibody CSLEX1; however, only rare tissue macrophages in uninflamed nonlymphoid sites showed expression of SLex. These observations are consistent with the concept that SLex on circulating PMN and monocytes functions as a ligand for endothelial E-selectin in the development of inflammatory reactions. SLex-positive lymphocytes also were seen, notably, T lymphocytes in inflamed skin. An unexpected finding was that the CSLEX1 antibody also reacted with venular endothelium in certain lymphoid tissues and in inflamed appendix, but not with endothelium in normal appendix. Whether the SLex antigen identified on endothelium represents de novo expression or passive adsorption remains to be determined.
A Market Discovery Algorithm to Estimate a General Class of Nonparametric Choice Models (2014)

We propose an approach for estimating customer preferences for a set of substitutable products using only sales transactions and product availability data. The underlying demand framework combines a general, nonparametric discrete choice model with a Bernoulli process of arrivals over time. The choice model is defined by a discrete probability mass function (pmf) on a set of possible preference rankings of alternatives, and it is compatible with any random utility model. An arriving customer is assumed to purchase the available option that ranks highest in her preference list. The problem we address is how to jointly estimate the arrival rate and the pmf of the rank-based choice model under a maximum likelihood criterion. Since the potential number of customer types is factorial, we propose a market discovery algorithm that starts with a parsimonious set of types and enlarge it by automatically generating new types that increase the likelihood value. Numerical experiments confirm the potential of our proposal. For a realistic data set in the hospitality industry, our approach improves the root mean square errors between predicted and observed purchases computed under independent demand model estimates by 67% to 93%. This paper was accepted by Serguei Netessine, operations management.
Fabrication of beam steering elements and couplers with grayscale lithography using HEBS glass (2005)

The fabrication of reflective, refractive and coupling optical elements using a new technique for grayscale lithography with high-energy beam-sensitive glass is discussed. These devices were used to demonstrate short-reach optical interconnects and new imaging concepts.
Dynamic Prediction of Project Success Using Artificial Intelligence (2007)

The purpose of construction management is to successfully accomplish projects, which requires a continuous monitoring and control procedure. To dynamically predict project success, this research proposes an evolutionary project success prediction model (EPSPM). The model is developed based on a hybrid approach that fuses genetic algorithms (GAs), fuzzy logic (FL), and neural networks (NNs). In EPSPM, GAs are primarily used for optimization, FL for approximate reasoning, and NNs for input-output mapping. Furthermore, the model integrates the process of continuous assessment of project performance to dynamically select factors that influence project success. The validation results show that the proposed EPSPM, driven by a hybrid artificial intelligence technique, could be used as an intelligent decision support system, for project managers, to control projects in a real time base.
Multifrequency electron paramagnetic resonance and electron-nuclear double-resonance studies of photo-hole processes in AgBr and AgCl emulsion grains (2000)

By using a combination of multifrequency EPR spectroscopy, ENDOR spectroscopy and calculations of structure and energy, the reactivities of photo-generated holes in microcrystalline AgBr and AgCl dispersions (photographic emulsions) have been followed in detail. Progress has been facilitated by the use of both gelatin and polyvinyl alcohol (PVA) as peptizers. The initial trapped hole centres produced by band-gap excitation have been identified. In AgBr, this species is [(Br4)3-·V], a neutral complex formed from hole trapping by the four nearest neighbours of a surface Ag+ vacancy (=V). [(Br4)3-·V] reacts with gelatin to produce a transient organic radical at the grain's surface. It does not, however, react with PVA. The formation of the oxidized gelatin radical might involve atomic bromine as an intermediate. In AgCl, the well-known self-trapped hole centre (AgCl6)4- is the initial hole species. The hole diffuses by an electron exchange process until it is trapped by a silver ion on the grain's surface or within its penultimate layer of lattice ions. It is subsequently released from this Ag2+ site to be retrapped at a centre containing four equivalent Cl- ions. The precise identity of this defect has yet to be determined, but its decay also results in the oxidation of gelatin.
Aptamers as Drug Delivery Vehicles (2014)

The benefits of directed and selective therapy for systemic treatment are reasons for increased interest in exploiting aptamers for cell-specific drug delivery. Nucleic acid based pharmaceuticals represent an interesting and novel tool to counter human diseases. Combining inhibitory potential and cargo transfer upon internalization, nanocarriers as well as various therapeutics including siRNAs, chemotherapeutics, photosensitizers, or proteins can be imported via these synthetic nucleic acids. However, widespread clinical application is still hampered by obstacles that must be overcome. In this review, we give an overview of applications and recent advances in aptamer-mediated drug delivery. We also introduce prominent selection methods as well as useful approaches in choice of drug and conjugation method. We discuss the challenges that need to be considered and present strategies that have been applied to achieve intracellular delivery of effectors transported by readily internalized aptamers.
Remote Camera-based Pulse Oximetry (2014)

Abstract—The oxygen concentration in the blood is a very important physiological parameter. This variable is ordinarily monitored using a pulse oximeter, a device that measures the proportion of Hemoglobin that carries oxygen. Although noninva-sive, this device needs constant contact with the patient’s skin. The possibility of performing the same measurement without contact using a color camera and ambient light is investigated in this work. Particularly, the presence of signals necessary to oximetry measurement on recorded videos is evaluated. It was found that photo-plethysmographic signals are present at two color channels simultaneously, depending on the analyzed region of the videos. Thus, remote camera-based oximetry is possible in principle. Such a device could find numerous applications for patient monitoring, either at the hospital or at home. Keywords-pulse oximetry; contactless; camera; SpO2. I.