gebhart/patrepeval huggingface dataset:
Selective and Responsive Nanoreactors (2011)

Abstract Chemical reactions can be confined to nanoscale compartments by encapsulating catalysts in hollow nanoobjects. Such reaction compartments effectively become nanoreactors when substrate and product are exchanged between bulk solution and cavity. A key issue, thereby, is control of shell permeability. Nanoreactors exhibit selectivity and responsiveness if their shells discriminate among molecules and if access can be modulated by external triggers. Here, we review natural nanoreactors that include protein‐based bacterial microcompartments, protein cages, and viruses. Artificial nanoreactors based on dendrimers, layer‐by‐layer capsules, and amphiphilic block copolymer polymersomes are also discussed. Selectivity in these nanoreactors is either due to intrinsic reactor‐shell semipermeability or can be engineered using smart polymers to gate the reactors. Moreover, a rich repertoire of pores and channels are already provided in nature, e.g., in protein‐based nanoreactors or in trans‐membrane channel proteins. The latter can be reconstituted in polymersomes, resulting in gated vesicles. Nanoreactors hold promise for applications ranging from selective and size‐constrained organic synthesis to biomedical advances (e.g., artificial organelles, biosensing) and as analytical tools to study reaction mechanisms.
Tuning the Morphology of Solution-Sheared P3HT:PCBM Films (2016)

PSS substrates yielding face-on orientation at the substrate-film interface, an orientation highly favorable for organic solar cells.
Reverse time migration of prism waves for salt flank delineation (2013)

In this paper, we present a new reverse time migration method for imaging salt flanks with prism wave reflections. It consists of four steps: (1) migrating the seismic data with conventional RTM to give the RTM image; (2) using the RTM image as a reflectivity model to simulate source-side reflections with the Born approximation; (3) zero-lag correlation of the source-side reflection wavefields and receiver-side wavefields to produce the prism wave migration image; and (4) repeating steps 2 and 3 for the receiver-side reflections. An advantage of this method is that there is no need to pick the horizontal reflectors prior to migration of the prism waves. It also separately images the vertical structures at a different step to reduce crosstalk interference. The disadvantage of prism wave migration algorithm is that its computational cost is twice that of conventional RTM. The empirical results with a salt model suggest that prism wave migration can be an effective method for salt flank delineation in the absence of diving waves.
Determination of Complex Formation Constants of Lipophilic Neutral Ionophores in Solvent Polymeric Membranes with Segmented Sandwich Membranes (1999)

A potentiometric method to determine ionophore complex formation constants in solvent polymeric membrane phases, proposed originally by Russian researchers, is critically evaluated and compared to other established methods. It requires membrane potential measurements on two-layer sandwich membranes, where only one side contains the ionophore. The resulting initial membrane potential reflects the ion activity ratio at both aqueous phase−membrane interfaces and can be conveniently used to calculate complex formation constants in situ. This method is potentially useful, since it does not require the use of a reference ion or second ionophore in the measurement. In this paper, the five ionophores valinomycin, BME-44, ETH 2120, tert-butylcalix[4]arene tetraethyl ester, and S,S‘-methylenebis(diisobutyldithiocarbamate) are characterized in poly(vinyl chloride) (PVC) plasticized with dioctyl sebacate (DOS) and compared with other established methods. The resulting formation constants correspond well to literature values. The influence of varying membrane concentrations and different anionic site additives is studied and found to be relatively small. Experiments are also performed with and without lipophilic inert electrolytes and with ionophore-free sandwich membranes to illustrate the effect of ion pairing and the membrane internal diffusion potential on the response of such sandwich membranes. These experiments suggest that ions are completely associated in PVC−DOS membranes, but that such ion pairs are rather nonspecific. Diffusion potentials seem to play a minor role with these systems. The results are explained with theory. This work indicates that the characterization of electrically charged ionophores, anion-selective ionophores, and ionophores in membrane matrixes other than PVC plasticized with DOS may now be experimentally accessible.
Selection and parameterization of cortical neurons for neuroprosthetic control (2006)

When designing neuroprosthetic interfaces for motor function, it is crucial to have a system that can extract reliable information from available neural signals and produce an output suitable for real life applications. Systems designed to date have relied on establishing a relationship between neural discharge patterns in motor cortical areas and limb movement, an approach not suitable for patients who require such implants but who are unable to provide proper motor behavior to initially tune the system. We describe here a method that allows rapid tuning of a population vector-based system for neural control without arm movements. We trained highly motivated primates to observe a 3D center-out task as the computer played it very slowly. Based on only 10-12 s of neuronal activity observed in M1 and PMd, we generated an initial mapping between neural activity and device motion that the animal could successfully use for neuroprosthetic control. Subsequent tunings of the parameters led to improvements in control, but the initial selection of neurons and estimated preferred direction for those cells remained stable throughout the remainder of the day. Using this system, we have observed that the contribution of individual neurons to the overall control of the system is very heterogeneous. We thus derived a novel measure of unit quality and an indexing scheme that allowed us to rate each neuron's contribution to the overall control. In offline tests, we found that fewer than half of the units made positive contributions to the performance. We tested this experimentally by having the animals control the neuroprosthetic system using only the 20 best neurons. We found that performance in this case was better than when the entire set of available neurons was used. Based on these results, we believe that, with careful task design, it is feasible to parameterize control systems without any overt behaviors and that subsequent control system design will be enhanced with cautious unit selection. These improvements can lead to systems demanding lower bandwidth and computational power, and will pave the way for more feasible clinical systems.
Ghrelin protects mice against endotoxemia-induced acute kidney injury (2009)

Acute kidney injury (AKI) in septic patients drastically increases the mortality to 50-80%. Sepsis is characterized by hemodynamic perturbations as well as overwhelming induction of proinflammatory cytokines. Since ghrelin has been shown to have anti-inflammatory properties, we hypothesized that ghrelin may afford renal protection during endotoxemia-induced AKI. Studies were conducted in a normotensive endotoxemia-induced AKI model in mice by intraperitoneal injection of 3.5 mg/kg LPS. Serum ghrelin levels were increased during endotoxemia accompanied by increased ghrelin receptor (GHSR-1a) protein expression in the kidney. Ghrelin administration (1.0 mg/kg sc 6 h and 30 min before and 14 h after LPS) significantly decreased serum cytokine levels (TNF-alpha, IL-1beta, and IL-6) and serum endothelin-1 levels which had been induced by LPS. The elevated serum nitric oxide (NO) levels and renal inducible NO synthase expression were also decreased by ghrelin. Renal TNF-alpha levels were also increased significantly in response to LPS and ghrelin significantly attenuated this increase. When administrated before LPS, ghrelin protected against the fall in glomerular filtration rate at 16 h (172.9 +/- 14.7 vs. 90.6 +/- 15.2 microl/min, P < 0.001) and 24 h (147.2 +/- 20.3 vs. 59.4 +/- 20.7 microl/min, P < 0.05) as well as renal blood flow at 16 h (1.65 +/- 0.07 vs. 1.47 +/- 0.04 ml/min, P < 0.01) and 24 h (1.56 +/- 0.08 vs. 1.22 +/- 0.03 ml/min, P < 0.05) after LPS administration without affecting mean arterial pressure. Ghrelin remained renal protective even when it was given after LPS. In summary, ghrelin offered significant protection against endotoxemia-induced AKI. The renal protective effect of ghrelin was associated with an inhibition of the proinflammatory cytokines. Of particular importance was the suppression of TNF-alpha both in the circulation and kidney tissues. Thus, ghrelin may be a promising peptide in managing endotoxemia-induced AKI.
Ultrasonic Method for Aircraft Wake Vortex Detection (2006)

This paper describes the experimental proof of concept study for an ultrasonic method of wake vortex detection. This new acoustic method uses travel time of acoustic pulses around a closed path to measure the net circulation within the acoustic path. In this application the closed path encloses the vorticity shed from one side of a Piper PA-28 aircraft wing. Magnitude and sign of circulation detected is comparable to the expected circulation generated by the Piper PA-28 test aircraft. This study demonstrates the validity of the acoustic method in detecting aircraft wake vortices. Further investigations and applications using this technique are discussed.
Improved β-SiC heteroepitaxial films using off-axis Si substrates (1987)

All β-SiC films grown using on-axis (001) Si substrates that have been examined with transmission electron microscopy exhibit a high density of interfacial twins, stacking faults, and antiphase disorder. The antiphase boundaries can be decorated by chemical etching, sputter etching, wet oxidation, and β-SiC growth in the presence of diborane. All traces of antiphase disorder are eliminated when the heteroepitaxial growth is carried out on vicinal (001) Si substrates that are tilted 2° about a 〈110〉 axis. In addition, growth on the off-axis Si produces β-SiC films that are significantly smoother than on-axis films. The density of stacking faults is apparently unaffected by growth on the off-axis substrates.
Chemical Mechanical Polishing of Ta (1999)

Chemical mechanical polishing (CMP) of tantalum was performed using alumina and fumed silica particles dispersed in chemical environments that are relevant to CMP. The highest tantalum polish rate was obtained with the abrasives dispersed in deionized water and, in all cases investigated here, the polish rate decreased with the addition of the oxidant. Rotating disk electrode studies showed an increase in the open‐circuit potential with time, saturating eventually, in the absence of abrasion indicating the formation of a passive film. Nevertheless, in situ electrochemical measurements (with abrasion) show that the open‐circuit potential is lower during polishing. This indicates that the passive film is being removed, at least partially, during polishing exposing a less noble surface. ©2000 The Electrochemical Society
EMENDATIONS TO MENANDER's DYSKOLOS (1959)

EMENDATIONS TO MENANDER's DYSKOLOS Get access E. G. Turner E. G. Turner Search for other works by this author on: Oxford Academic Google Scholar Bulletin of the Institute of Classical Studies, Volume 6, Issue 1, December 1959, Pages 61–72, https://doi.org/10.1111/j.2041-5370.1959.tb00625.x Published: 12 March 2010
Online learning for demand response (2015)

Demand response is a key component of existing and future grid systems facing increased variability and peak demands. Scaling demand response requires efficiently predicting individual responses for large numbers of consumers while selecting the right ones to signal. This paper proposes a new online learning problem that captures consumer diversity, messaging fatigue and response prediction. We use the framework of multi-armed bandits model to address this problem. This yields simple and easy to implement index based learning algorithms with provable performance guarantees.
Videodisk Standards: A Software View of the Technology (1983)

Software for audiovisual systems can be divided into two classes: linear and nonlinear. The first is intended for collective viewing over broadcast media, thus excluding individual user control over the flow and delivery of the program. The second explicitly aims at such user control, and is therefore unsuitable for broadcast purposes. Several technologies compete as delivery systems for both classes, including videodisk, videotape, film, slide projectors, and some computers. While linear software can usually run on many of these systems, nonlinear software will often run only on the replay devices for which it was originally devised. Standardization of software of this type is desirable for a variety of reasons. It is proposed to specify a high-level language to this end, along the lines of computer high-level languages. This could be used to specify programs for videodisk players and for a variety of other delivery systems.
Knowledge-Based System for Source Rock Prediction: ABSTRACT (1987)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Research Guides: BIZ Research Center: Business Writing and Research Design (2012)

This is a virtual business library created particularly for University of Tennessee, Knoxville
Real-Time Trailer Scheduling for Crossdock Operations (2008)

Abstract Crossdocks play an important role in supply chain operations. Due to the need to decrease transportation lead time to coordinate with other supply chain activities such as just-in-time, make-to-order, or merge-in-transit strategies, shortening the total transfer time at crossdocks is increasingly important. In this research, we use real-time information about freight transferring within a crossdock to schedule waiting inbound trailers in order to reduce the time freight spends in a crossdock. We use dynamic simulation models to compare the performance of several strategies. These are first-come, first-served, look-ahead, minimum processing time, and minimum total time policies. We examine these under different trailer arrival headways, crossdock layouts, and destination distributions. Our simulation results show that our time-based algorithms save more time than the first-come, first-served and look-ahead policies. In addition, these algorithms appear to result in higher service reliability and productivity.
Sheffer Polynomials for Computing Exact Kolmogorov-Smirnov and Renyi Type Distributions (1981)

Sheffer polynomials are used for proving algorithms and closed forms for a broad class of nonlinear one-sided order and rank distributions. For two-sided tests a more general concept results in a representation theorem for piecewise Sheffer polynomial functions.
3-Mercaptopropionate Dioxygenase, a Cysteine Dioxygenase Homologue, Catalyzes the Initial Step of 3-Mercaptopropionate Catabolism in the 3,3-Thiodipropionic Acid-degrading Bacterium Variovorax paradoxus (2008)

The thioether 3,3-thiodipropionic acid can be used as precursor substrate for biotechnological synthesis of 3-mercaptopropionic acid-containing polythioesters. Therefore, the hitherto unknown catabolism of this compound was elucidated to engineer novel and improved polythioester biosynthesis pathways in the future. Bacteria capable of using 3,3-thiodipropionic acid as the sole source of carbon and energy for growth were enriched from the environment. From eleven isolates, TBEA3, TBEA6, and SFWT were morphologically and physiologically characterized. Their 16 S rDNAs and other features affiliated these isolates to the beta-subgroup of the proteobacteria. Tn5::mob mutagenesis of isolate Variovorax paradoxus TBEA6 yielded ten mutants fully or partially impaired in growth on 3,3-thiodipropionic acid. Genotypic characterization of two 3,3-thiodipropionic acid-negative mutants demonstrated the involvement of a bacterial cysteine dioxygenase (EC 1.13.11.22) homologue in the further catabolism of the 3,3-thiodipropionic acid cleavage product 3-mercaptopropionic acid. Detection of 3-sulfinopropionate in the supernatant of one of these mutants during cultivation on 3,3-thiodipropionic acid as well as in vivo and in vitro enzyme assays using purified protein demonstrated oxygenation of 3-mercaptopropionic acid to 3-sulfinopropionate by this enzyme; cysteine and cysteamine were not used as substrate. Beside cysteine dioxygenase and cysteamine dioxygenase, this 3-mercaptopropionic acid dioxygenase is the third example for a thiol dioxygenase and the first report about the microbial catabolism of 3-mercaptopropionic acid. Insertion of Tn5::mob in a gene putatively coding for a family III acyl-CoA-transferase resulted in the accumulation of 3-sulfinopropionate during cultivation on 3,3-thiodipropionic acid, indicating that this compound is further metabolized to 3-sulfinopropionyl-CoA and subsequently to propionyl-CoA.
Ferroceniumsalze ‐ die ersten tumorhemmenden Eisenverbindungen (1984)

Der überraschenden Wirkung des Kations in 1 gegen Ehrlich‐Ascites‐Tumor der Maus muß ein anderes Prinzip zugrunde liegen als der Wirkung der Metallocen‐dihalogenide d‐elektronenarmer Übergangsmetalle, denn die Anionen in 1 sind nicht koordiniert, sondern salzartig gebunden. Ferrocen ist beim gleichen Testsystem inaktiv. magnified image
Analgesia mediated by spinal kappa-opioid receptors. (1991)

The results from 44 experiments performed on 13 rats with chronically implanted lumbar subarachnoid catheters are reported. ICI 197 067 produced dose-dependent segmental analgesic effects when measurement of electrical current threshold for pain was used as the nociceptive test. Ten microliters of intrathecal ICI 197 067 (0.06 mg ml-1; 1.5 nmol) caused a significant rise in the current threshold for pain in the tail of 1.56 +/- 0.04 x control (mean +/- SEM) but no significant change in pain threshold in the neck (1.03 +/- 0.03 x control). By contrast, simultaneous measurements of tail-flick latency in these animals revealed no significant rise in pain thresholds using this nociceptive test. Intraperitoneally administered naloxone produced a dose-dependent suppression of the spinally mediated analgesic effect produced by ICI 197 067; the ED50 for this effect was 0.79 mumol kg-1, a value very close to the ED50 for naloxone antagonism of ketocyclazocine spinally mediated analgesia. We conclude that ICI 197 067 produces spinally mediated analgesia by binding to spinal-cord kappa-opioid receptors.
Substitutes for Ammonium Sulfate as Additives with Glyphosate and Glufosinate<sup>1</sup> (2003)

Glyphosate and glufosinate are now options for postemergence weed control in herbicide-resistant corn and soybean. Velvetleaf is one of the more difficult to control annual weeds with these herbicides at commonly used rates. Ammonium sulfate (AMS) is generally used with these herbicides to overcome hard water antagonism and to increase herbicide activity. Greenhouse and field trials were conducted with commercial adjuvants that might substitute for AMS. The adjuvants were evaluated in deionized water, tap water, and deionized water containing 500 mg/L CaCO3. In the absence of AMS, hard water reduced velvetleaf control with both herbicides. Regardless of water source, AMS increased velvetleaf control with both glyphosate and glufosinate. Several adjuvants increased velvetleaf control with either herbicide; however, none were superior to 2% w/v AMS. Other adjuvants decreased velvetleaf control with either herbicide.Nomenclature: Ammonium sulfate; glufosinate; glyphosate; velvetleaf, Abutilon theophrasti Medic #3 ABUTH; corn, Zea mays L. # ZEAMA; soybean, Glycine max (L.) Merr. # GLYMA.Additional index words: Ammonium sulfate, glufosinate, glyphosate.
Treatment of Diet‐Resistant Polygenic Hypercholesterolaemic Patients with a New Nicotinate Derivative; In Vivo and In Vitro Low Density Lipoprotein Metabolic Studies (1989)

Six patients (four women and two men) with mild to moderate hypercholesterolemia, but with no clinical evidence of the disease being monogenic familial hypercholesterolaemia and who, over the previous 3 months on a rigidly controlled hypolipidaemic diet therapy, showed no reduction in plasma cholesterol levels, were recruited into a study to assess the metabolic effects of Pirozadil, a new nicotinic acid derivative. After a 3 month treatment period, a significant reduction in plasma cholesterol from 299.8 +/- 31.2 mg/dl (mean +/- SD) to 256.8 +/- 18.1 mg/dl (P less than 0.02) and Low Density Lipoprotein (LDL) cholesterol from 211.7 +/- 44.9 mg/dl to 168.8 +/- 19.0 mg/dl (P less than 0.05) was observed. Although there was a trend toward decreased plasma and Very Low Density Lipoprotein (VLDL) triglyceride, the differences did not reach statistical significant. High Density Lipoprotein (HDL) cholesterol was unchanged. The drug was well tolerated with no side effects noted. To assess the mode of action, autologous125I-labelled LDL was injected and apoprotein B (apo B) kinetic parameters were measured; production rate (PR) and fractional catabolic rate (FCR). An in vitro measurement of the in vivo catabolism (LDL-apo B receptor activity in freshly isolated lymphocytes) was also measured pre- and post-treatment. The pharmacological intervention resulted in a significant decrease of 19.9% in PR from 10.5 +/- 1.81 mg/kg/d to 8.41 +/- 1.13 mg/kg/d (P less than 0.05) while the FCR remained relatively unchanged (0.260 +/- 0.042 vs 0.248 +/- 0.040 pools/d) as did the LDL receptor activity (78.2 +/- 20.9 vs 69.3 +/- 21.4 ng LDL/mg cell protein/hr).(ABSTRACT TRUNCATED AT 250 WORDS)
Dimensional Synthesis of Bennett Linkages (2000)

Abstract This paper presents a synthesis procedure for a spatial 4R linkage, known as Bennett’s linkage. It is known that the two solutions of the RR chain synthesis equations form a Bennett linkage. While analytical solutions to these equations have been developed previously, this paper uses the cylindroid that is known to exist for a Bennett linkage to simplify the solution process. It is interesting that geometric constraint associated with the spatial 4R chain simplifies the solution of the RR chain design equations. An example design is presented.