gebhart/patrepeval huggingface dataset:
Cutting Edge: Paradoxical Roles of BST2/Tetherin in Promoting Type I IFN Response and Viral Infection (2012)

Bone marrow stromal Ag 2 (BST2) is a transmembrane protein that prevents virus release from infected cells. It was also reported that BST2 inhibits type I IFN production by plasmacytoid dendritic cells. To determine BST2 impact on antiviral responses in vivo, we generated BST2(-/-) mice. Following infection with a murine retrovirus, BST2(-/-) mice had slightly elevated viral loads; however, infection with other enveloped viruses revealed unexpected roles of BST2. BST2(-/-) mice showed reduced type I IFN production by plasmacytoid dendritic cells. Moreover, BST2(-/-) mice had lower viral titers in lungs following intranasal infection with vesicular stomatitis virus expressing OVA and influenza B and increased numbers of virus-specific CD8 T cells in the lungs, suggesting that BST2 may facilitate entry and/or replication of enveloped viruses and modulate priming of CD8 T cells. These findings suggest complex roles of BST2 beyond retroviral control in vivo, possibly reflecting the involvement of BST2 in endocytosis and intracellular trafficking of viruses, viral nucleic acids, and Ags.
Sieving of Hot Gases by Hyper-Cross-Linked Nanoscale-Hybrid Membranes (2013)

Macromolecular networks consisting of homogeneously distributed covalently bonded inorganic and organic precursors are anticipated to show remarkable characteristics, distinct from those of the individual constituents. A novel hyper-cross-linked ultrathin membrane is presented, consisting of a giant molecular network of alternating polyhedral oligomeric silsesquioxanes and aromatic imide bridges. The hybrid characteristics of the membrane are manifested in excellent gas separation performance at elevated temperatures, providing a new and key enabling technology for many important industrial scale applications.
Organisation of safety measures in an Alpine World Junior Championship (2001)

A significantly higher injury rate was recorded for young female than young male racers. The injury rate was significantly higher in downhill than the other alpine disciplines in the Alpine World Junior Championship. The injury rate was not significantly different from that recorded one year previously for Olympic racers, and juniors therefore need the same safety measures as Olympic racers.
Glucose Inhibition Persists in Hypothalamic Neurons Lacking Tandem-Pore K<sup>+</sup>Channels (2009)

Glucose sensing by hypothalamic neurons triggers adaptive metabolic and behavioral responses. In orexin neurons, extracellular glucose activates a leak K(+) current promoting electrical activity inhibition. Sensitivity to external acidification and halothane, and resistance to ruthenium red designated the tandem-pore K(+) (K(2P)) channel subunit TASK3 as part of the glucose-induced channel. Here, we show that glucose inhibition and its pH sensitivity persist in mice lacking TASK3 or TASK1, or both subunits. We also tested the implication of another class of K(2P) channels activated by halothane. In the corresponding TREK1/2/TRAAK triple knock-out mice, glucose inhibition persisted in hypothalamic neurons ruling out a major contribution of these subunits to the glucose-activated K(+) conductance. Finally, block of this glucose-induced hyperpolarizing current by low Ba(2+) concentrations was consistent with the conclusion that K(2P) channels are not required for glucosensing in hypothalamic neurons.
Effect of type of dialysis membrane on bone in haemodialysis patients (2001)

Dialysis with CELL membrane was associated with increased bone turnover whereas the use of AN-69 membrane was associated with decreased bone turnover, suggesting a beneficial effect of the latter on high-turnover uraemic bone disease. However, as the number of patients with repeat bone biopsies was small, these findings need to be confirmed in a larger study. Further studies are also needed to evaluate whether or not the changes in IGF system components play a role in decreased bone cell activity in patients on dialysis using the AN-69 polyacrylonitrile membrane.
An antibody that binds domain 1 of CD4 inhibits replication of HIV-1, but not HTLV-I, in a CD4-positive/p56lck-negative HTLV-I-transformed cell line (1996)

mAbs that bind to the Ig CDR3-like region in D1 domain of the CD4 molecule can inhibit the HIV-1 life cycle in CD4-positive T cells and lymphoblastoid cell lines at the stage of transcription. This antiviral effect requires the integrity of the cytoplasmic tail of CD4, which acts as a signal transduction region through its association with protein tyrosine kinases such as p56Ick. Here we investigated the role of p56Ick in the cascade of molecular events that control HIV-1 transcription in cells treated with anti-CD4 mAb directed against the Ig CDR3-like region. The Ig CDR3-like region-specific mAb, 13B8-2, blocked HIV-1 production in CD4-positive/p56Ick-negative HTLV-I-producing MT2 cells superinfected by HIV-1Lai, but had no effect on HTLV-I production, although it did inhibit Tax-induced NF-kappa B translocation. These results raise the possibility that an as yet unidentified tyrosine kinase may be capable of associating with CD4 and mediating intracellular signaling.
Two novel power-down circuits on the 1Mb CMOS SRAM (1988)

This paper describes two novel power down circuits suitable for high density CMOS SRAMs. One is self-timed power down (SPD) scheme which employs self-timed mechanism for the data read-out completion. The other is automatic power down scheme on the write operation (APDW). The effectiveness of these new circuits is demonstrated on a 1M bit CMOS SRAM.
A modified HME architecture for text-dependent speaker identification (1996)

A modified hierarchical mixtures of experts (HME) architecture is presented for text-dependent speaker identification. A new gating network is introduced to the original HME architecture for the use of instantaneous and transitional spectral information in text-dependent speaker identification. The statistical model underlying the proposed architecture is presented and learning is treated as a maximum likelihood problem; in particular, an expectation-maximization (EM) algorithm is also proposed for adjusting the parameters of the proposed architecture. An evaluation has been carried out using a database of isolated digit utterances by 10 male speakers. Experimental results demonstrate that the proposed architecture outperforms the original HME architecture in text-dependent speaker identification.
Deconvolution of cellular subsets in human tissue based on targeted DNA methylation analysis at individual CpG sites (2020)

This proof of concept study demonstrates that DNAm analysis at individual CpGs reflects the cellular composition of cellular mixtures and different tissues. Targeted analysis of these genomic regions facilitates robust methods for application in basic research and clinical settings.
Models for time coalescence in event logs (2003)

One heuristic for data reduction that is widely used in the literature is coalescence of events occurring close in time. The authors explore the validity of this heuristic by developing a model for the formation of the contents of an event log by multiple independent error processes. The probability of coalescing events from two or more error sources is formulated and compared with results from hand analysis of actual event logs taken from a Tandem TNS II system. Results indicate that the probability of coalescing events from more than one error source is a strong function of the time constant selected. The model can be used to select an appropriate time constant and also has implications in designing event logging systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Molecular nanoelectronics for label free DNA analysis (2003)

An ultrasensitive nanogap junction is developed for label-free biomolecular detection. The nanogap junction can minimize the effects of electrode polarization. Without any label, dielectric detection of DNA hybridization is accomplished: the 70% and 12% changes of capacitance after hybridization were accomplished at 100 Hz for 10 /spl mu/M and 10 fM concentrations of target DNA, respectively. The nanogap junction-based dielectric DNA detection method and the batch fabrication method of nanogap junctions might able to change the paradigm of functional genomics and proteomics.
Controlled Crystallization of the Amorphous Phase in Silicon Nitride Ceramics (1987)

The controlled crystallization of amorphous second phases in SiAlON is demonstrated in two systems. In a magnesia‐containing SiAlON, cordierite crystallized on annealing after hot‐pressing. Similarly, garnet crystallized in yttria‐contain‐ing SiAlON. The resulting microstructures are characterized by TEM and qualitatively related to changes on room‐temperature toughness and high‐temperature deformation.
Smart Differential Pressure Sensor with Bluetooth Communication Interface (2008)

This paper presents design and assembly of mixed electronic circuitry for measured signal processing of the capacitive difference pressure sensor, as well as analysis of the obtained results. The smart pressure sensor provides values of measured pressure via 4-20 mA current loop output. The loop current is also used for sensor circuitry supplying. This means that current consumption of the whole sensor electronics should be less than 3.5 mA even in extended industrial temperature range from -40 to +125degC.
Oxygen content of superconducting perovskites, lanthanum strontium copper oxide La2-xSrxCuOy and yttrium barium copper oxide YBa2Cu3Oy (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxygen content of superconducting perovskites, lanthanum strontium copper oxide La2-xSrxCuOy and yttrium barium copper oxide YBa2Cu3OyEvan H. Appelman, Lester R. Morss, Aravinda M. Kini, Urs Geiser, A. Umezawa, G. W. Crabtree, and K. Douglas CarlsonCite this: Inorg. Chem. 1987, 26, 20, 3237–3239Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://doi.org/10.1021/ic00267a003Request reuse permissionsArticle Views842Altmetric-Citations181LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (408 KB) Get e-Alertsclose Get e-Alerts
How could N-Methyl-D-Aspartate Receptor Antagonists Lead to Excitation Instead of Inhibition? (2018)

N-methyl-D-aspartate receptors (NMDARs) are a family of ionotropic glutamate receptors mainly known to mediate excitatory synaptic transmission and plasticity. Interestingly, low-dose NMDAR antagonists lead to increased, instead of decreased, functional connectivity; and they could cause schizophrenia- and/or antidepressant-like behavior in both humans and rodents. In addition, human genetic evidences indicate that NMDAR loss of function mutations underlie certain forms of epilepsy, a disease featured with abnormal brain hyperactivity. Together, they all suggest that under certain conditions, NMDAR activation actually lead to inhibition, but not excitation, of the global neuronal network. Apparently, these phenomena are rather counterintuitive to the receptor's basic role in mediating excitatory synaptic transmission. How could it happen? Recently, this has become a crucial question in order to fully understand the complexity of NMDAR function, particularly in disease. Over the past decades, different theories have been proposed to address this question. These include theories of “NMDARs on inhibitory neurons are more sensitive to antagonism”, or “basal NMDAR activity actually inhibits excitatory synapse”, etc. Our review summarizes these efforts, and also provides an introduction of NMDARs, inhibitory neurons, and their relationships with the related diseases. Advances in the development of novel NMDAR pharmacological tools, particularly positive allosteric modulators, are also included to provide insights into potential intervention strategies.
Technology and Universal Health Coverage: Examining the role of digital health (2021)

While there is tremendous promise to leverage technology for UHC, it will require smart, context-specific policies and programming with ample flexibility to adapt as needs and opportunities change - and with robust safeguards to protect privacy, data security, and equity. The health sector, by its very nature of being data intensive, lends itself to the use of technology for analytics to improve health outcomes, respond to public health crises, and efficiently and equitably allocate resources. The first imperative in considering the use of digital health to expand UHC is to remember that digital health is a means to an end, and only one of the available means. Efforts leveraging digital health to move along that path to universality have taken many forms: to increase the number of people reached, to provide enhanced service coverage, and to reduce the financial burdens on individuals in need of health care. Making use of digital health interventions is an evolving process, not a one-time decision point. It is context specific and needs a clear vision to move from pilot interventions to scaled implementation. Technology can be a key tool in achieving UHC but its use has to be strategic, judicious, and cognizant of issues around privacy and patient rights.
Two year results: sharp versus rounded optic edges on silicone lenses (2000)

To evaluate the role of optic edge design of 2 silicone intraocular lenses (IOLs) in 2 year clinical results. Department of Ophthalmology, University of Vienna, Medical School, Allgemeines Krankenhaus, Austria. In this comparative clinical study, 50 eyes had phacoemulsification and implantation of a high-refractive 3-piece silicone IOL with sharp optic edges (CeeOn model 911F) (n = 25) or a 3-piece silicone lens with rounded optic edges (CeeOn model 920) (n = 25). Biomicroscopic findings, including those of specular microscopic examination of the anterior lens surface, were documented and the results analyzed. After 2 years, a significant between-group difference in posterior capsule opacification (PCO) but not in anterior capsule alterations was observed. Behind all CeeOn 911F sharp-edge IOLs, the capsule remained clear; in 2 of 23 capsules behind the CeeOn 920 rounded-edge, a neodymium: YAG laser capsulotomy had to be performed for dense central fibrotic PCO. Seven of 21 of the remaining eyes had first-degree central fibrotic PCO, 14 of 23 had peripheral mixed fibrotic and slender Elschnig pearl PCO, and 8 of 23 had second-degree peripheral PCO. Specular microscopic findings did not differ between the 2 groups. No severe IOL decentration occurred in any eye; 25% in the sharp-edge group and 40% in the rounded-edge group had minimal decentration. The silicone IOL with the sharp optic edge design was associated with significantly reduced PCO 2 years postoperatively.
A Survey of Low Duty Cycle MAC Protocols in Wireless Sensor Networks (2011)

This chapter examines various important low duty cycle MAC protocols and the two most important MAC protocols designed specifically for cooperative Multiple-Input Multiple-Output (MIMO) transmission. In most cases, the low duty cycle MAC protocols trade off latency for energy efficient operation. Also, we can observe later that asynchronous MAC protocols are more scalable than synchronous MAC protocols. On the one hand, when sensor nodes join or leave a group or a cluster, the MAC needs to resynchronise the network over and over in such protocols as LEACH and S-MAC. Frequent re-synchronisation can lead to higher energy consumption. The situation becomes more complex when global synchronisation is required instead of local synchronisation. Thus a balance must be made between frequent synchronisation and scalability in synchronous MAC protocol design. On the other hand, in some cases with asynchronous MAC, the higher scalability comes at the cost of higher transmission energy due to the implementation of a long preamble and overhearing in such protocols as RF Wake-up and B-MAC. However, the burden of long preamble transmission is reduced gradually by the introduction of short packet techniques such in SpeckMAC and X-MAC. Moreover, it is important to note that little attention has been paid to increasing the link reliability in SISO systems. The only mechanism used is the ACK packet feedback in protocols such IEEE 802.15.4 MAC and WiseMAC. The MIMO-LEACH and CMAC ON protocols provide measures to increase link reliability and at the same time reduce transmission power by exploiting spatial diversity gain. On the one hand, the MIMO-LEACH protocol employs a duty cycle mechanism through TDMA time slots assignments which reduces the total energy consumption. Furthermore, multihop communication between cluster heads is introduced to replace the direct communication which reduces further the total energy consumption. Also, collisions can be avoided with the distinct time slot assignment to each sensor node. The benefits come at the cost of higher latency (multi-hop communication). In addition, the scalability issue is not addressed at all. CMAC ON is more scalable and does not require pre-selection of cooperative nodes. CMAC ON does not suffer from tight synchronisation and overhead of cluster formation. Also, collision avoidance is provided through RTS-CTS signalling. Moreover, an ACK 5 www.intechopen.com
Analytical Model to Predict the Effect of Pipe Friction on Downhole Temperatures for Extended-Reach Drilling (ERD) (2012)

Abstract The advent of extended-reach drilling (ERD) has led to increased effects of friction on the drillstring and the drilling fluid. Wellbore mechanical friction attributable to pipe rotation or to torque and drag plays a significant role in drilling operations and is considered to influence the temperatures downhole. An analytical mathematical model will help to provide physical insight to understand the borehole conditions. This study aims to develop a simple mathematical model to analyze the heat generated from borehole friction and to predict the temperature of the drilling fluid during a drilling operation at any depth in the well. The model presents a steady-state solution for heat transfer between the drillstring and the fluids in the drillpipe and annulus, as well as heat transfer between the annular fluid and the formation. Heat generated from friction has been modeled using the torque acting on the drillstring as a result of contact forces. A linear temperature gradient for the formation and a constant borehole wall temperature has been assumed to simplify the model. Frictional pressure losses in the drill pipe, in the annulus, and across the bit have been incorporated in the model because they contribute to the heat generated in the borehole. This paper will present the derivations of the generalized heat transfer model and the application of the model in a field case. The temperature of the drilling fluid has been calculated both in the annulus as well as inside the drillpipe at various depths for the considered well profile. The drillstring temperature profile has been estimated using the calculated drilling fluid temperatures. Wellbore mechanical friction and downhole temperatures were thoroughly studied by varying the underlying drilling parameters in the model.
Diagnostic biomarkers differentiating metastatic melanoma patients from healthy controls identified by an integrated MALDI‐TOF mass spectrometry/bioinformatic approach (2007)

The prognosis of advanced metastatic melanoma (American Joint Committee on Cancer (AJCC) stage IV) remains dismal with a 5-year survival rate of 6-18%. In the present study, an integrated MALDI mass spectrometric approach combined with artificial neural networks (ANNs) analysis and modeling has been used for the identification of biomarker ions in serum from stage IV melanoma patients allowing the discrimination of metastatic disease from healthy status with high specificities of 92% for protein ions and 100% for peptide biomarkers. Our ANNs model also correctly classified 98% of a blind validation set of AJCC stage I melanoma samples as nonstage IV samples, emphasizing the power of the newly defined biomarkers to identify patients with late-stage metastatic melanoma. Sequence analysis identified peptides derived from metastasis-associated proteins; alpha 1-acid glycoprotein precursor-1/2 (AAG-1/2) and complement C3 component precursor-1 (CCCP-1). Furthermore, quantitation of serum AAG by an immunoassay showed a significant (p<0.001) increase in AAG serum concentration in stage IV patients in comparison with healthy volunteers; moreover; the quantity of AAG plotted against MALDI-MS peak intensity classified the groups into two distinct clusters. Ongoing studies of other disease stages will provide evidence whether our strategy is sufficiently robust to give rise to stage-specific protein/peptide signatures in melanoma.
DNA sequence of lipoprotein lipase cDNA cloned from human monocytic leukemia THP-1 cells (1990)

Journal Article DNA sequence of lipoprotein lipase cDNA cloned from human monocytic leukemia THP-1 cells Get access Atsuko Takagi, Atsuko Takagi Department of Etiology and Pathophysiology, National Cardiovascular Center Research InstituteFujishirodai, Suita, Osaka 565, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yasuyuki Ikeda, Yasuyuki Ikeda Department of Etiology and Pathophysiology, National Cardiovascular Center Research InstituteFujishirodai, Suita, Osaka 565, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Akira Yamamoto Akira Yamamoto Department of Etiology and Pathophysiology, National Cardiovascular Center Research InstituteFujishirodai, Suita, Osaka 565, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 21, 21 November 1990, Page 6436, https://doi.org/10.1093/nar/18.21.6436 Published: 21 November 1990 Article history Received: 26 September 1990 Published: 21 November 1990
On processor allocation in hypercube multiprocessors (2003)

The processor allocation problem in a hypercube system is to find a free subcube for a given request. The subcube recognition capability of existing allocation strategies, e.g. the buddy strategy and the Gray code strategy, is far below the theoretical upper bound due to their incomplete representation of the hypercube interconnection structure. A complete strategy that outperforms the existing ones in subcube recognition capability and average waiting time but incurs a higher overhead is proposed. Efficient implementation of the complete strategy is also studied.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>