gebhart/patrepeval huggingface dataset:
The Basic Science and Surgical Treatment Options for Articular Cartilage Injuries of the Knee (2012)

The complex structure of articular cartilage allows for diverse knee function throughout range of motion and weight bearing. However, disruption to the structural integrity of the articular surface can cause significant morbidity. Due to an inherently poor regenerative capacity, articular cartilage defects present a treatment challenge for physicians and therapists. For many patients, a trial of nonsurgical treatment options is paramount prior to surgical intervention. In instances of failed conservative treatment, patients can undergo an array of palliative, restorative, or reparative surgical procedures to treat these lesions. Palliative methods include debridement and lavage, while restorative techniques include marrow stimulation. For larger lesions involving subchondral bone, reparative procedures such as osteochondral grafting or autologous chondrocyte implantation are considered. Clinical success not only depends on the surgical techniques but also requires strict adherence to rehabilitation guidelines. The purpose of this article is to review the basic science of articular cartilage and to provide an overview of the procedures currently performed at our institution for patients presenting with symptomatic cartilage lesions.
Shaping perceptions to motivate healthy behavior: The role of message framing. (1997)

Health-relevant communications can be framed in terms of the benefits (gains) or costs (losses) associated with a particular behavior, and the framing of such persuasive messages influences health decision making. Although to ask people to consider a health issue in terms of associated costs is considered an effective way to motivate behavior, empirical findings are inconsistent. In evaluating the effectiveness of framed health messages, investigators must appreciate the context in which health-related decisions are made. The influence of framed information on decision making is contingent on people, first, internalizing the advocated frame and, then, on the degree to which performing a health behavior is perceived as risky. The relative effectiveness of gain-framed or loss-framed appeals depends, in part, on whether a behavior serves an illness-detecting or a health-affirming function. Finally, the authors discuss the cognitive and affective processes that may mediate the influence of framed information on judgment and behavior.
Regulatory mechanism of nm23-H1 expression in hepatocellular carcinoma analized by several electrophoresis. (1996)

転移抑制遺伝子のひとつであるnm23-H1遺伝子産物の発現は肝癌細胞の転移能に逆相関することを明らかにしたが, その機序を検索するにあたり施行したノーザンブロットとウエスタンブロットに相反する結果が認められた. しかし, PCR-SSCP, サザンブロットおよびマイクロサテライト解析を加えて検索することにより, nm23-H1遺伝子産物の発現は肝癌細胞においては主に転写後に制御されるという結論を得た. このように遺伝子産物の発現機序の解明には複数の電気泳動法による検索とそれらの結果を総合して解析することが重要であると考えられた.
A Mossbauer study of the magnetic properties of CuFe alloys (1976)

The Mossbauer effect has been used to investigate the magnetic properties of Cu-Fe alloys of concentration 0.24-4.6% Fe in the temperature range 4.2-100K and in applied magnetic fields of up to 8.0 T. Alloys containing more than about 0.5% Fe exhibited magnetic broadening at 4.2K and the transition temperatures at which the broadening first occurred have been determined. The distributions of hyperfine magnetic fields observed in these specimens below the transition temperatures have been studied as functions of iron concentration and of temperature. The saturation hyperfine fields for isolated iron atoms are found to vary with concentration, exhibiting a linear variation at high concentrations but falling more rapidly at lower concentration. This is interpreted as evidence for the formation of a Kondo state. Spectra obtained at high magnetic fields indicate some anisotropy in the impurity response to the applied field.
Addition of carvedilol to University Wisconsin solution improves rat steatotic and nonsteatotic liver preservation (2010)

Here we examine the effect of adding carvedilol (CVD) to University of Wisconsin (UW) solution on the preservation of steatotic and nonsteatotic livers during cold ischemia and after normothermic reperfusion. We used an isolated perfused rat liver model. The following protocols were evaluated. Protocol 1 concerned the effect of CVD after cold ischemia. Steatotic and nonsteatotic livers were preserved for 24 hours in UW solution alone or with CVD. Livers without cold ischemia were used as controls. Transaminases were evaluated in the flushing effluent. Protocol 2 involved the effect of CVD after reperfusion. Both liver types were preserved for 24 hours in UW solution alone or with CVD and then perfused ex vivo for 2 hours at 37 degrees C. Livers flushed and perfused without ischemia were used as controls. Hepatic injury and functionality [transaminases, bile production, and hepatic clearance of sulfobromophthalein (BSP)] were evaluated after reperfusion. In addition, factors potentially involved in hepatic ischemia-reperfusion injury, including oxidative stress (malondialdehyde and superoxide anion levels), mitochondrial damage (glutamate dehydrogenase activity), microcirculatory disorders (flow rate and vascular resistance), and adenosine triphosphate (ATP) depletion, were evaluated after reperfusion. After cold ischemia, steatotic livers preserved in UW solution showed higher transaminase levels than nonsteatotic livers. After reperfusion, steatotic livers preserved in UW solution showed higher transaminase levels and lower bile production and BSP clearance than nonsteatotic livers. Alterations in the perfusion flow rate and vascular resistance, mitochondrial damage, and reduced ATP content were more evident in steatotic livers preserved in UW solution. The addition of CVD to UW solution reduced hepatic injury, obstructed its mechanisms, and improved hepatic functionality in both liver types. We conclude that CVD is a useful additive for UW solution that improves the preservation of steatotic and nonsteatotic livers subjected to prolonged cold ischemia.
Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV (2017)

Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells contribute to the body's immune defenses. Current chimeric antigen receptor (CAR)-modified T cell immunotherapy shows strong promise for treating various cancers and infectious diseases. Although CAR-modified NK cell immunotherapy is rapidly gaining attention, its clinical applications are mainly focused on preclinical investigations using the NK92 cell line. Despite recent advances in CAR-modified T cell immunotherapy, cost and severe toxicity have hindered its widespread use. To alleviate these disadvantages of CAR-modified T cell immunotherapy, additional cytotoxic cell-mediated immunotherapies are urgently needed. The unique biology of NK cells allows them to serve as a safe, effective, alternative immunotherapeutic strategy to CAR-modified T cells in the clinic. While the fundamental mechanisms underlying the cytotoxicity and side effects of CAR-modified T and NK cell immunotherapies remain poorly understood, the formation of the immunological synapse (IS) between CAR-modified T or NK cells and their susceptible target cells is known to be essential. The role of the IS in CAR T and NK cell immunotherapies will allow scientists to harness the power of CAR-modified T and NK cells to treat cancer and infectious diseases. In this review, we highlight the potential applications of CAR-modified NK cells to treat cancer and human immunodeficiency virus (HIV), and discuss the challenges and possible future directions of CAR-modified NK cell immunotherapy, as well as the importance of understanding the molecular mechanisms of CAR-modified T cell- or NK cell-mediated cytotoxicity and side effects, with a focus on the CAR-modified NK cell IS.
A $c^k n$ 5-Approximation Algorithm for Treewidth (2016)

We give an algorithm that for an input n-vertex graph G and integer κ > 0, in time 2O(κ)n, either outputs that the treewidth of G is larger than κ, or gives a tree decomposition of G of width at most 5κ + 4. This is the first algorithm providing a constant factor approximation for treewidth which runs in time single exponential in κ and linear in n. Treewidth-based computations are subroutines of numerous algorithms. Our algorithm can be used to speed up many such algorithms to work in time which is single exponential in the treewidth and linear in the input size.
Loss of Caspase-8 Expression Does Not Correlate with <i>MYCN</i> Amplification, Aggressive Disease, or Prognosis in Neuroblastoma (2006)

Inactivation of caspase-8 because of aberrant gene methylation has been associated with amplification of the MYCN oncogene and aggressive disease in neuroblastoma, suggesting that caspase-8 may function as tumor suppressor. However, the prognostic effect of caspase-8 in neuroblastoma has remained obscure. Therefore, we investigated caspase-8 expression and its correlation with established prognostic markers and survival outcome in a large cohort of neuroblastoma patients. Here, we report that loss of caspase-8 protein expression occurs in the majority (75%) of neuroblastoma and is not restricted to advanced disease stages. Surprisingly, no correlation was observed between caspase-8 expression and MYCN amplification. Similarly, ectopic expression of MYCN or antisense-mediated down-regulation of MYCN had no effect on caspase-8 expression in neuroblastoma cell lines. In addition, caspase-8 expression did not correlate with other variables of high-risk disease (e.g., 1p36 aberrations, disease stage, age at diagnosis, or tumor histology). Most importantly, loss of caspase-8 protein had no effect on event-free or overall survival in the overall study population or in distinct subgroups of patients. By revealing no correlation between caspase-8 expression and MYCN amplification or other established variables of aggressive disease, our findings in a large cohort of neuroblastoma patients show that inactivation of caspase-8 is not a characteristic feature of aggressive neuroblastoma. Thus, our study provides novel insight into the biology of this tumor, which may have important clinical implications.
Service Oriented Database Architecture (2005)

As the capabilities and service levels of enterprise database systems have evolved, they have collided with incumbent technologies such as TP-Monitors or Message Oriented Middleware (MOM). We believe this trend will continue and have architected the upcoming release of SQL Server to advance this technology trend. This paper describes the Service Oriented Database Architecture (SODA) developed for the Microsoft SQL Server DBMS. First, it motivates the need for building Service Oriented Architecture (SOA) features directly into a database engine. Second, it describes a set of features in SQL Server that have been designed for SOA use. Finally, it concludes with some thoughts on how SODA can enable multiple service deployment topologies.
Growth-related enzymatic control of glycogen metabolism in cultured human tumor cells. (1984)

The activities of glycogen synthase and phosphorylase were measured and compared to the growth-related variations of glycogen accumulation in three cultured human tumor cell lines: HT-29 (colon carcinoma); MeWo (malignant melanoma); and RT-4 (carcinoma of the urinary bladder). A similar pattern of variations in the enzyme activities was found in the three cell lines. The activities of the a + b forms of glycogen phosphorylase increased throughout the culture period. Maximal activity of phosphorylase a coincided with low intracellular concentrations of glycogen during the period of exponential growth. When the rate of cell division decreased, phosphorylase a activity also decreased while the glycogen levels increased. Glycogen synthase was almost entirely in b form during the entire culture period, i.e., in both the exponential and the stationary phases. In vitro incubation of the cellular extracts without NaF showed, however, that the enzyme could be partially converted to the a form by the endogenous phosphatases. The A0.5 values of the enzyme for glucose-6-phosphate (Glc-6-P) were of the same order of magnitude as the intracellular Glc-6-P concentrations which ranged from 2.2 to 5.4 mM (almost 10 times those reported in normal cells). Similar Glc-6-P values were obtained by two different extraction methods controlled by the intracellular ATP and ADP concentrations. The Km values for uridine-5'-diphosphoglucose were always 2 to 3 times lower than the intracellular uridine-5'-diphosphoglucose concentrations. These results suggest that: (a) in these tumor cells, glycogen is essentially synthesized by glycogen synthase b via an allosteric activation by intracellular Glc-6-P; (b) there is no obvious growth-related control of glycogen synthase activity; and (c) the activity of glycogen phosphorylase seems to be growth dependent with maximal phosphorylase a activities associated with the period of high division rate.
Design of Stud-Shear Reinforcement For Slabs (1990)

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Fatigue and Durability of Silane-Bonded Epoxy/Glass Interfaces (2001)

Abstract Fatigue (slow) crack growth in epoxy/glass interfaces bonded with the silane coupling agent 3-aminopropyltriethoxysilane was studied under static and cyclic loading at 23°C, 95% RH using the double cleavage drilled compression test. Crack growth rates under cyclic loading were significantly greater than under static loading, in contrast to crack growth rate results in monolithic glass. After aging up to 34 h at 94°C in distilled water, the silane-bonded epoxy/glass specimens exhibited somewhat greater resistance to fatigue crack growth than the unaged samples; however, after aging at 98°C in distilled water and at 70°C in an aqueous KOH solution at pH 10, crack growth became cohesive and exhibited fractal behavior. Mechanisms for fatigue crack growth at silane-bonded epoxy/glass interfaces are proposed.
Constructing optimal search trees in optimal time (1999)

(a, b)-trees are an important class of search trees. They include 2-3 trees, 2-3-4 trees, and B-trees as subclasses. We show that a space-minimum (a, b)-tree is also height-minimum and present an optimal algorithm for constructing (a, b)-trees that are height-minimum and space-minimum. Given n keys, our algorithm constructs an (a, b)-tree with minimum height and lowest possible nodes. Our algorithm takes /spl Theta/(n) time if the keys in S are sorted and /spl Theta/(n log n) time if the keys are not sorted. We also discuss possible applications of our algorithm.
Incorporating a Bridging Program into an Engineering Degree (1990)

The structure and content of a bridging programme which forms part of a double degree course, B. E. ( Civil )/ B. Bus. ( Bus. Admin.) are described, and the reasons for choosing them given. Some changes based on these concepts were introduced into the B.E. (Civil) course when it was revised. Initial results from both courses indicate that these programmes are worthwhile.
Evidence of porcine and human endothelium activation by cancer‐associated carbohydrates expressed on glycoproteins and tumour cells (2003)

It is well established that after metastatic cancer cells escape the primary tumour and enter the circulation, their interactions with microvascular endothelium of a target organ constitute an essential rate-limiting step in haematogenous cancer metastasis. However, the physiological and biochemical processes supporting neoplastic cell arrest and retention in the microcirculation are still poorly understood. In this study, we present experimental evidence that microvascular endothelium of metastasis-prone tissues undergoes activation in response to desialylated cancer-associated carbohydrate structures such as Thomsen-Friedenreich (TF) antigen (Galbeta1-3GalNAc) expressed on circulating glycoproteins and neoplastic cells. The metastasis-associated endothelium activation, manifested by marked increase in endothelial cell surface galectin-3 expression, causes gradual decrease in cancer cell velocities (from 72 x 10(2)+/- 33 x 10(2) microm s-1 to 7.6 x 10(2)+/- 1.9 x 10(2) microm s-1, mean +/-s.d.) accompanied by a corresponding increase in the percentage of rolling cells (from 3.3%+/- 1.2% to 24.3%+/- 3.6%, mean +/-s.d.), and results in human breast and prostate carcinoma cell arrest and retention in the microvasculature. This process, which could be of high importance in haematogenous cancer metastasis, was inhibited efficiently by an anti-TF antigen function-blocking antibody. Carbohydrate-mediated endothelial activation could be a process of physiological significance as it probably occurs in the interactions between a variety of circulating constituents and the vessel wall.
Colloidal particles at liquid interfaces (2007)

1. Particles at liquid interfaces - an introduction B. P. Binks and T. S. Horozov 2. Structure and formation of particle monolayers at liquid interfaces L. Bergstrom 3. Theory for interactions between particles in monolayers J. C. Fernandez-Toledano, A. Moncho-Jorda, F. Martinez-Lopez and R. Hidalgo-Alvarez 4. Particle-assisted wetting W. A. Goedel 5. Particle-laden interfaces: rheology, coalescence, adhesion and buckling G. G. Fuller, E. J. Stancik and S. Melle 6. Solids-stabilized emulsions: a review R. J. G. Lopetinksy, J. H. Masliyah and Z. Xu 7. Novel materials derived from particles assembled on liquid surfaces K. P. Velikov and O. D. Velev 8. Interfacial particles in food emulsions and foams E. Dickinson 9. Collection and attachment of particles by air bubbles in froth flotation A. V. Nguyen, R. J. Pugh and G. J. Jameson 10. Antifoam effects of solid particles, oil drops and oil-solid compounds in aqueous foams N. D. Denkov and K. G. Marinova 11. Metal foams: towards high temperature colloid chemistry N. Babcsan and J. Banhart.
Light absorption by a dipole (1983)

In semiclassical radiation theory, the electric dipole moment induced on an atom by a strong incident field, absorbs much more energy, per sec, than is flowing through its geometrical cross section. This means, the atom has the capability to suck electromagnetic energy from a spatial region that is by far larger than its own volume. An intuitive understanding of this effect is provided by studying, in the framework of classical electrodynamics, the energy flow in the total field made up by superposition of the incident wave and the field that is generated by the dipole also in the absorptive case.
Linomide reduces the rate of active lesions in relapsing-remitting multiple sclerosis (1996)

The synthetic immunomodulator Linomide, a quinoline-3-carboxamide, has a profound inhibitory influence in several experimental autoimmune diseases, including acute and chronic experimental allergic encephalomyelitis. In a double-blind trial, 31 patients with relapsing-remitting multiple sclerosis were randomized to oral doses of 2.5 mg Linomide or placebo once a day for six months. Fourteen patients receiving Linomide and 14 receiving placebo completed the trial, and the results were based on this population. The mean number of active (new and enlarged T2 weighted) lesions per monthly MRI scan was 1.37 in the patients receiving Linomide and 4.22 in the patients receiving placebo (p = 0.043). The percentage of scans with active MRI lesions was lower in the Linomide-treated group (p = 0.0064). When neurologic deficit was assessed by the Regional Functional Scoring System (RFSS), the Linomide group showed an improvement of 1% of the maximal RFSS range and the placebo group a deterioration of 0.2% (p = 0.14). There were three patients with relapses in the Linomide-treated group and six in the placebo group (p = 0.22). A slightly decreased proportion of natural killer cells in cerebrospinal fluid and peripheral blood was noted in the Linomide group. A severe adverse event of pleuropericarditis occurred in one of the Linomide-treated patients. The most frequent adverse event was musculoskeletal pain, of mild to severe degree, which tended to diminish after three months on Linomide therapy.
Instrument-Based Noncontact Doppler Radar Vital Sign Detection System Using Heterodyne Digital Quadrature Demodulation Architecture (2009)

In this paper, we present a fast solution to build a Doppler radar system for noncontact vital sign detection (VSD) using instruments that are generally equipped in radio-frequency and communication laboratories. This paper demonstrates the feasibility of conducting research on VSD in ordinary radio-frequency laboratories. The system is designed with a heterodyne digital quadrature demodulation architecture that helps mitigate quadrature channel imbalance and eliminate the complicated dc offset calibration required for arctangent demodulation. Moreover, its tunable carrier frequency helps select different optimal frequencies for different human objects. Two sets of extensive experiments have been carried out in the laboratory environment with a self-designed 2.4-GHz patch antenna array and a 1-18-GHz broadband antenna. The test results are satisfactory: for a 0-dBm transmit power, the detection range can be extended to 2.5 m with accuracy higher than 80%. The system is also capable of detecting vital signs in the presence of different obstructions between the subject and the antenna.
A Library Implementation of POSIX Threads under UNIX. (1993)

Recently, there has been an effort to specify an IEEE standard for portable operating systems for open systems, called POSIX. One part of it, the POSIX 1003.4a threads extension (Pthreads for short) [12], describes the interface for light-weight threads that rely on shared memory and have a smaller context frame than processes. This paper describes and evaluates the design and implementation of a library of Pthreads calls that is solely based on UNIX. It shows that a library implementation is feasible and can result in good performance. This work can also be used as a comparison of the performance of other implementations, or as a prototyping, testing, and debugging system in the regular UNIX environment. Finally, some problems with the Pthreads standard are identified. Introduction Light-weight threads are independent threads of control within a regular process that share global data (global variables, files, etc.) but maintain their own stack, local variables, and program counter. ...
Block convolution: Towards memory-efficient inference of large-scale CNNs on FPGA (2018)

FPGA-based CNN accelerators are gaining popularity due to high energy efficiency and great flexibility in recent years. However, as the networks grow in depth and width, the great volume of intermediate data is too large to store on chip, data transfers between on-chip memory and off-chip memory should be frequently executed, which leads to unexpected offchip memory access latency and energy consumption. In this paper, we propose a block convolution approach, which is a memory-efficient, simple yet effective block-based convolution to completely avoid intermediate data from streaming out to off-chip memory during network inference. Experiments on the very large VGG-16 network show that the improved top-1/top-5 accuracy of 72.60%/91.10% can be achieved on the ImageNet classification task with the proposed approach. As a case study, we implement the VGG-16 network with block convolution on Xilinx Zynq ZC706 board, achieving a frame rate of 12.19fps under 150MHz working frequency, with all intermediate data staying on chip.