gebhart/patrepeval huggingface dataset:
DNA Vaccines Approach: From Concepts to Applications (2014)

DNA vaccines are the third generation vaccines based on purified plasmid preparations containing transgenes that encode antigenic/therapeutic proteins or peptides capable of triggering an immune response against a wide range of diseases. This vaccine platform presents several attributes that confer distinct advantages over other vaccine technologies in terms of safety, ease of fabrication and stability. Many aspects, such as antigen expression and especially vector design, are under study because of their great influence on immunogenicity and efficacy of DNA vaccines. In this regard, with the attempt of improving the efficiency of DNA vaccines, co-expression of stimulatory sequences and diverse vector delivery systems are being optimized. With this in mind, this review aims to giving a conceptual approach of DNA vaccines, explaining their mechanisms of action and listing the already licensed veterinary DNA vaccines presented in the market.
Immunodeficiency of the Elderly (1987)

The elderly are at risk for an increased incidence and severity of certain infections. The contribution of age-related immunologic impairment to the pathogenesis of these infections has been difficult to determine because of a number of confounding variables associated with aging. Nevertheless, studies in vitro and in animals support the hypothesis that immunodeficiency accompanies the aging process. Multiple factors may be responsible for altered cell-mediated immunity in the elderly, including thymic involution, reduced levels of thymic hormones, and an increase in the number of immature T lymphocytes. While studies of T cell subpopulations have yielded conflicting results, it appears that T cell proliferative responses are diminished. Aging is also associated with abnormalities of humoral immunity. Although the number and functional activities of neutrophils from healthy elderly persons are relatively intact, diminished bactericidal activity and altered oxygen metabolism have been reported in extremely old individuals. While the relative importance and clinical impact of these immunologic abnormalities remain unclear, future studies may provide new strategies for the prevention and treatment of infections in this rapidly growing segment of the population.
Bone formation processin porous calcium carbonate and hydroxyapatite (1992)

This study determined the bone formation in porous calcium carbonate (CC) and porous hydroxyapatite (HA) in ectopic sites. The bone formation stimulus was derived from bone marrow cells. CC and HA in the shape of disks were implanted with or without rat marrow cells into subcutaneous sites of syngeneic rats. The CC and HA had identical microstructure: pore size was 190-230 microns, porosity was 50-60% and they were fully interconnected. Bone did not form in any implants without marrow cells (disks themselves), whereas bone consistently formed in the pores of all implants with marrow cells after 4 weeks. The bone formation of both CC and HA occurred initially on surface of the pore regions and progressed toward the center of the pore. Scanning electron microscopy and electron-probe microanalysis revealed a continuum of calcium at the interfaces of both bone/CC and bone/HA implants. These results indicate that the bone formation in calcium carbonate derived from marine corals is comparable to the bioactive hydroxyapatite.
Hepatic Arterial Infusion Versus Systemic Therapy for Hepatic Metastases From Colorectal Cancer: A Randomized Trial of Efficacy, Quality of Life, and Molecular Markers (CALGB 9481) (2006)

HAI therapy increased overall survival, response rate, THP, and was associated with better physical functioning compared with systemic therapy. Additional studies need to address the overall benefit and cost of new chemotherapy agents versus HAI alone or the combination of HAI with new agents.
Intracavity frequency doubling of a continuous-wave, diode-laser-pumped neodymium lanthanum scandium borate laser (1994)

Neodymium-doped lanthanum scandium borate [Nd:LaSc(3)(BO(3))(4)] is a new material for efficient and compact diode-pumped solid-state lasers. A simple plane-plane 3-mm-long resonator is formed by a coated Nd(10%):LaSc(3)(BO(3))(4) crystal and a coated potassium titanyl phosphate (KTP) crystal. The second-harmonic output power at 531 nm is 522 mW at 2.05-W incident pump power of the diode laser. The corresponding optical efficiency is 25%, and the conversion efficiency from the fundamental to the second harmonic is 55%. The wellknown chaotic power fluctuations of intracavity frequency-doubled lasers (green problem) are avoided by use of a short KTP crystal, between 0.5 and 2 mm in length.
An Instrument for the Testing of Prisms1 (1923)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. W. Moffitt, "An Instrument for the Testing of Prisms1," J. Opt. Soc. Am. 7, 831-852 (1923) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Abstract 231: Cardiac Myosin Binding Protein C Couples Cross-Bridge Cycling to Calcium Transients to Provide Normal Cardiac Function (2012)

A 40-year old American has a 20% chance of developing heart failure (HF) in his/her lifetime. Although cross-bridge cycling forms the basis for contraction and relaxation of the heart, mechanisms that modulate cross-bridge cycling are not completely understood, nor are the alterations in these processes in HF. Cardiac myosin binding protein-C (MyBPC3) is a component of heart muscle that is believed to regulate cross-bridge cycling kinetics. We hypothesize that MyBPC3 tunes cross-bridge cycling to the [Ca2+]i transient to produce normal cardiac function, which we tested using our MyBPC3 knockout (KO) mouse. Echocardiography showed that MyBPC3(KO) hearts exhibited abbreviated aortic ejection durations (AED) and AED/(period between heart beats) ratio compared to WT. MyBPC3(KO) hearts also had smaller velocity-time integrals which indicate smaller stroke volumes as a result of abbreviated ejection. Brain natriuretic peptide expression level, heart weight/body weight, and lung weight/body weight were all increased in MyBPC3(KO) mice, consistent with HF. MyBPC3(KO) mice also exhibit increased 1-year mortality. We used simultaneous twitch force and intracellular calcium [Ca2+]i measurements on intact papillary muscles to evaluate the consequences of losing cross-bridge cycling regulation on force response to changing [Ca2+]i transients. MyBPC3 (KO) myocardium exhibited abbreviated contractions despite slower calcium transients and an inability to accelerate relaxation with respect to peak contraction. Therefore, loss of MyBPC3-mediated coupling of cross-bridge cycling to the [Ca2+]i transient was associated with contractile dysfunction and HF.
Oxygen-Containing Groups on the Surface of Carbon Black (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxygen-Containing Groups on the Surface of Carbon BlackMerton L. Studebaker, E. W. D. Huffman, A. C. Wolfe, and L. G. NaborsCite this: Ind. Eng. Chem. 1956, 48, 1, 162–166Publication Date (Print):January 1, 1956Publication History Published online1 May 2002Published inissue 1 January 1956https://pubs.acs.org/doi/10.1021/ie50553a044https://doi.org/10.1021/ie50553a044research-articleACS PublicationsRequest reuse permissionsArticle Views685Altmetric-Citations123LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Electrochemical and photochemical treatment of aqueous waste streams (1996)

Carbon aerogel electrodes have been used to remove NH{sub 4}ClO{sub 4} and heavy metals from aqueous waste streams. Photochemical oixdation with H{sub 2}O{sub 2} has been used to destroy organic contamination and is proposed as a means of avoiding the fouling of carbon aerogel electrodes.
Nonmechanical zoom lens based on the Pancharatnam phase effect (2016)

We present a nonmechanical zoom lens system based on the Pancharatnam phase effect, which is controlled by the state of circularly polarized light. The device is shown to allow for a compact design for a wide range of zoom ratios. A demonstration system is shown, which has a 4× zoom ratio between its two electrically switchable states. We show its observed image quality experimentally and compare it with calculated expectations.
IgG4-related pleural disease in a patient with pulmonary adenocarcinoma under durvalumab treatment: a case report (2020)

This was a case of IgG4-related pleural disease in a patient with pulmonary adenocarcinoma under durvalumab treatment. To our knowledge, this is the first case report of IgG4-related pleural disease as an irAE. It is important to consider the possibility of IgG4-related pleural disease in cases of pleural effusion during the treatment with ICIs.
EPAS: an emitter piloting advisory expert system for IC emitter deposition (1990)

Emitter piloting is a difficult diffusion process in IC manufacturing. The decision for the adjustment of the piloting drive cycle is a heuristic-oriented task. An expert system, the emitter piloting advisory system (EPAS), is used at Harris Semiconductor to advise fab operators on how to adjust piloting cycle time for emitters based on knowledge extracted from the most experienced engineer. EPAS consists of an input filter to validate the input parameter values; a knowledge base containing the knowledge extracted from the domain expert; a limited learning mechanism for dynamically calculating a better estimate of initial drive time for the next lot; a convergence control mechanism to control the rule inference so that the result of an inference is always closer to the conclusion; a user facility module containing many LISP-based modules developed to let the expert, engineers, and operators maintain the system by themselves; and a user-friendly interface. One EPAS operation example is provided.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Myth and regeneration of literature from a multidisciplinary perspective (2008)

To put in perspective the theme of the conference, I would say first that its theme and regeneration invites one to think of what myths can do. But how does myth act? On what does it act? Myth can be seen as an active principle within all cultures because its dynamic nature tends to transform cultural processes of a society. Needless to say, this postulate stems from an epistemological revalorisation of the notion of myth in anthropological studies since the dawn of the twentieth century (Freud, Cassirer) which the Grenoble anthropologist, Gilbert Durand, has used as the basic premise of his reflection. In other words, myth is not a mental illusion or a mental aberration (or a misconception). On the contrary, it is a privileged mode of the knowledge of man and societies. A society can be understood by simply analysing its myths or more generally its mythical creation. Myth is found everywhere: in literature, cinema, advertisements, paintings or music and even in daily used gadgets. Myth speaks to us, speaks about us and acts on us. We are its children, often without knowing it. It often forms part of our cultural and personal identities without our knowing it. In order to pinpoint the terms of a cultural action of myth, I will try to respond to the three following questions:
Is it not one of the intrinsic proprieties of myth that it resurrects itself like the phoenix? (The myth in this regard primarily acts on itself)
Is myth not what regenerates poetic creation? (In this instance myth acts on poetic enterprise)
Finally, can myth regenerate society? (After all, myth acts on society)
Supramolecular Functionalization of Single-Walled Carbon Nanotubes (SWNTs) with a Photoisomerizable Conjugated Polymer (2012)

A fluorene- and azobenzene-containing conjugated polymer, poly[2,7-(9,9-didodecylfluorene)-alt-4,4′-azobenzene] (F12AZO) has been successfully synthesized using Suzuki polycondensation. The introduction of two dodecyl chains on the flourene unit resulted in a highly soluble polymer. F12AZO possesses excellent thermal stability, with a decomposition temperature over 400 °C under Ar. The reversible photoisomerization of the azobenzene units was achieved upon alternating photoirradiation with light of wavelength less than 450 nm (cis-form), and light in the range of 450–600 nm (trans-form). The supramolecular complex formation of trans-F12AZO, and cis-F12AZO with single-walled carbon nanotubes (SWNTs) has been studied, and it was found that this polymer can form very strong supramolecular polymer-nanotube assemblies. Furthermore, the trans and cis isomers of F12AZO enable the selective dispersal of individual SWNTs in toluene or THF, and the selectivity of the SWNTs is strongly dependent on the solvent, as well as the type of isomer used. UV–vis–NIR, and photoluminescence–excitation spectroscopy (PLE) were used for the characterization and identification of the nanotube species that are solubilized and exfoliated by this polymer.
Effective inactivation of a wide range of viruses by pasteurization (2017)

Pasteurization is a very robust and reliable virus inactivation method with a broad effectiveness against known blood-borne pathogens and emerging or potentially emerging viruses. Pasteurization has proven itself to be a highly effective step, in combination with other complementary safety measures, toward assuring the virus safety of final product.
Evaluation of methods for differentiation of coagulase-positive staphylococci (1992)

The purpose of this study was to determine the minimum number of tests that could be used to differentiate between the coagulase-positive strains of staphylococcus: Staphylococcus aureus, Staphylococcus hyicus, and Staphylococcus intermedius. Eighty coagulase-positive strains of each of the three species were examined. The five tests conducted were growth on modified Baird-Parker agar, growth on P agar supplemented with acriflavin, production of acetoin, anaerobic fermentation of mannitol, and presence of beta-galactosidase. Positive test percentages for S. aureus were 100% for growth on modified Baird-Parker agar, 100% for growth on P agar supplemented with acriflavin, 94% for production of acetoin, 99% for anaerobic fermentation of mannitol, and 0% for presence of beta-galactosidase. Positive test percentages for S. intermedius were 0% for growth on modified Baird-Parker agar, 0% for growth on P agar supplemented with acriflavin, 1% for production of acetoin, 0% for anaerobic fermentation of mannitol, and 100% for presence of beta-galactosidase. S. hyicus isolates were negative in all five tests. Results from the 240 coagulase-positive staphylococcus strains tested would suggest correct identification of coagulase-positive staphylococci with P agar supplemented with acriflavin and the beta-galactosidase test. These two tests are simple to conduct and result in quick and easy differentiation of the three coagulase-positive staphylococcal species.
A novel treatment option for photoaged skin (2008)

Taken together, these results show that the combination of folic acid and creatine significantly accelerates epidermal skin regeneration in vitro and in vivo. Together with the finding of improved biomechanical skin properties, we conclude that the described topical formulation provides an effective treatment option for (photo)-aged skin.
Air oxidation of <i>d</i>‐limonene (the citrus solvent) creates potent allergens (1992)

Products containing as much as 95% of d-limonene are used for, e.g., degreasing metal before industrial painting and for cleaning assemblies. Experimental studies on the sensitizing potential of limonene show diverging results. In a previous study, we found that the sensitizing potential of d-limonene increased with prolonged air exposure. The aim of this study was to make further chemical analyses, to identify compounds formed by air exposure of d-limonene and to study their allergenic potential. d-limonene was found to be a sensitizer after prolonged exposure to air according to 2 Freund's complete adjuvant test (FCAT) experiments and 1 guinea pig maximization test (GPMT) study. No significant response was obtained to d-limonene not air exposed, even if the animals were sensitized to oxidized d-limonene. 5 main oxidation products of d-limonene were identified. (R)-(-)-carvone and a mixture of cis and trans isomers of (+)-limonene oxide were found to be potent sensitizers, while no significant reactions were obtained in the animals induced with a mixture of cis and trans isomers of (-)-carveol. It can be concluded that air oxidation of d-limonene is essential for its sensitizing potential, and that potent allergens are created.
Importance of conceptual geological models in 3D reservoir modelling (2016)

Conceptual Geological Models (CGM’s) represent geological knowledge and are traditionally visualized by 2D geologic crosssections. Construction of CGMs is a non-linear and complex process which involves application of geological rules and experience. These models describe essential features of geological situations, illustrate the principal processes of the petroleum system, and provide important information about reservoir characteristics, pressure and fluid flow of the field under study. The CGMs are being extensively used as the key input for 3D reservoir modelling and simulation at different stages of E&P projects. A fully integrated CGM building process consists of at least four stages: construction of one or more structural models, identification of depositional models, construction of sedimentary facies models and finally building of diagenetic facies models. This process requires integration of geological, geochemical, geophysical, and petrophysical data along with information from well testing and production into a comprehensive model describing the physical features of the geologic system. This paper briefly describes the different components of CGM and the model building process. The importance of integrating CGM in the 3D reservoir models has been demonstrated through an example of siliciclastic reservoir. This reservoir has complex internal sedimentary distribution and stratigraphy which leads to high subsurface uncertainties. The study shows that different possible conceptual geologic scenarios provide significantly different Hydrocarbon-In-Place, recoverable resources and production forecasts. Therefore, the successful application of appropriate CGM’s is critical for better 3D reservoir characterization and modelling which enables us to identify and rank the key reservoir uncertainties and assess their impact, establish interdependency of spatial property distribution, make volumetric assessments, plan the number and location of wells including their drainage area, optimize recovery efficiency and obtain reliable production forecasts.
Modulation of the Dimer Interface at Ionotropic Glutamate-Like Receptor δ2 by d-Serine and Extracellular Calcium (2009)

GluRdelta2 is a member of the iGluR family, but despite a prominent role in cerebellar synaptic plasticity, this receptor does not appear to function as an ion channel. Endogenous ligands that modulate the activity of native GluRdelta2 in the cerebellum have not been identified, but two candidate modulators are d-serine and extracellular calcium. Taking advantage of known crystal structures and spontaneously active GluRdelta2 receptors containing the lurcher mutation (GluRdelta2(Lc)), we investigated the mechanism by which calcium and d-serine regulate the activity of GluRdelta2(Lc). Our data suggest that calcium binding stabilizes the dimer interface formed between two agonist-binding domains and increases GluRdelta2(Lc) currents. The data further suggest that d-serine binding induces rearrangements at the dimer interface to diminish GluRdelta2(Lc) currents by a mechanism that resembles desensitization at AMPA and kainate receptors. Thus, we propose that calcium and d-serine binding have opposing effects on the stability of the dimer interface. Furthermore, the effects of calcium are observed at concentrations that are within the physiological range, suggesting that the ability of native GluRdelta2 to respond to ligand binding may be modulated by extracellular calcium. These findings place GluRdelta2 among AMPA and kainate receptors, where the dimer interface is not only a biologically important site for functional regulation, but also an important target for exogenous and endogenous ligands that modulate receptor function.
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma (2007)

Our recent study demonstrated that a novel proteasome inhibitor NPI-0052 triggers apoptosis in multiple myeloma (MM) cells, and importantly, that is distinct from bortezomib (Velcade) in its chemical structure, effects on proteasome activities, and mechanisms of action. Here, we demonstrate that combining NPI-0052 and bortezomb induces synergistic anti-MM activity both in vitro using MM cell lines or patient CD138(+) MM cells and in vivo in a human plasmacytoma xenograft mouse model. NPI-0052 plus bortezomib-induced synergistic apoptosis is associated with: (1) activation of caspase-8, caspase-9, caspase-3, and PARP; (2) induction of endoplasmic reticulum (ER) stress response and JNK; (3) inhibition of migration of MM cells and angiogenesis; (4) suppression of chymotrypsin-like (CT-L), caspase-like (C-L), and trypsin-like (T-L) proteolytic activities; and (5) blockade of NF-kappaB signaling. Studies in a xenograft model show that low dose combination of NPI-0052 and bortezomib is well tolerated and triggers synergistic inhibition of tumor growth and CT-L, C-L, and T-L proteasome activities in tumor cells. Immununostaining of MM tumors from NPI-0052 plus bortezomib-treated mice showed growth inhibition, apoptosis, and a decrease in associated angiogenesis. Taken together, our study provides the preclinical rationale for clinical protocols evaluating bortezomib together with NPI-0052 to improve patient outcome in MM.
An embedded infrastructure of debug and trace interface for the DSP platform (2008)

The paper presents an infrastructure for debug and trace of the embedded digital signal processor (DSP) system, consisting of the in-system trace interface and its methodology to optimize the compression rate of the program and data traces. The platform has been implemented in a multimedia dual-core SOC design with little area overhead. Both the benchmark evaluation and realistic system integration justified the efficiency and effectiveness of our approach.
Summary Abstract: Growth kinetics of thermally nitrided Si(100) by N2H4 (1987)

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