gebhart/patrepeval huggingface dataset:
Binding of Large Organic Anions and Neutral Molecules by Native Bovine Serum Albumin<sup>*</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBinding of Large Organic Anions and Neutral Molecules by Native Bovine Serum Albumin*Ashoka Ray, Jacqueline A. Reynolds, Helga Polet, and Jacinto SteinhardtCite this: Biochemistry 1966, 5, 8, 2606–2616Publication Date (Print):August 1, 1966Publication History Published online1 May 2002Published inissue 1 August 1966https://pubs.acs.org/doi/10.1021/bi00872a019https://doi.org/10.1021/bi00872a019research-articleACS PublicationsRequest reuse permissionsArticle Views281Altmetric-Citations164LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gentamicin-Induced Correction of CFTR Function in Patients with Cystic Fibrosis and<i>CFTR</i>Stop Mutations (2003)

In patients with cystic fibrosis who have premature stop codons, gentamicin can cause translational "read through," resulting in the expression of full-length CFTR protein at the apical cell membrane, and thus can correct the typical electrophysiological abnormalities caused by CFTR dysfunction.
Optimizing T gates in Clifford+T circuit as $\pi/4$ rotations around Paulis (2019)

In this work, we introduce a new circuit optimization technique to reduce the number of T gates in Clifford+T circuits by treating T gates conjugated by Clifford gates as $\frac{\pi}{4}$-rotations around Pauli operators. The tested benchmarks shows up to $71.43\%$ and an average $42.67\%$ reduction in T-count, both surpass the best performance reported. The worst case complexity of our algorithm is $O(nk^2)$ where $n$ is the number of qubits and $k$ is the number of T gates in the original Clifford+T circuit.
Synthesis and stereoselective reactions of 2-(pyrrol-1-yl)alkanals and 2-(pyrrol-1-yl)alkan-1-ones (1989)

2-(2,5-Dimethylpyrrol-1-yl)alkanals, 2-(pyrrol-1-yl)alkanals, and 2-(2,5-dimethylpyrrol-1-yl)alkan-1-ones were prepared. The reactions of these compounds with Grignard and hydride reagents proceeded stereoselectively to give the corresponding 2-(pyrrol-1-yl)alcohols, which were converted into 2- amino alcohols, such as norephedrine and ephedrine, by cleavage of the pyrrole ring.
Bacteria as Mediators of Copper Sulfide Enrichment During Weathering (1996)

Supergene chalcocite enrichment during weathering is an economically vital natural process that may lead to severalfold increases in the copper content of sulfide deposits. A scanning electron microscope study of chalcocite (Cu2S) from major enriched copper deposits in northern Chile revealed myriad bacterioform bodies in original growth positions near replacement interfaces with remnant hypogene sulfide grains. These minute (0.03 to 0.2 micrometers) chalcocite bodies are interpreted as fossilized and metallized nannobacteria that promoted the fixation of mobilized copper ions. Bacterial activity may thus be a fundamental factor in supergene enrichment of copper deposits.
Hormonal Changes after Roux-en Y Gastric Bypass for Morbid Obesity and the Control of Type-II Diabetes Mellitus (2004)

Morbid obesity (MO) is associated with diabetes mellitus-type II (DM-II). Roux-en Y gastric bypass (RNY) has been shown to normalize glucose intolerance in these patients through an incompletely understood mechanism. Gastrointestinal hormonal changes have been suggested as an explanation for resolution of DM II. Preoperatively, 20 MO patients with DM-II were evaluated for demographics and fasting levels of the following: glucose, insulin, C-peptide, glucagon, cortisol, gastric inhibitory polypeptide (GIP), and glucagon-like peptide-1 (GLP-1). Each patient underwent RNY with a 15-cc gastric pouch and 150-cm Roux limb. Postoperatively, each of the variables was measured at 2 weeks, 6 weeks, and 12 weeks and compared with the preoperative result using Student t test with significance, P = 0.05. Results are expressed as mean +/- SD. Twenty patients (5 male and 15 female), age 40.3 +/- 7.9 years, weight 146.3 +/- 34.0 kg, height 158.7 +/- 18.7 cm, and BMI 52.7 +/- 8.8, were enrolled in this IRB-approved protocol. Weight and BMI decreased progressively (117.5 +/- 26.9 kg and 47.0 +/- 7.4, P = 0.01, respectively) during the study but reached significance only at 12 weeks. Fasting plasma glucose decreased significantly within 2 weeks after RNY. Insulin and cortisol both approached, but never achieved, significant changes over 12 weeks. GLP-1 increased initially, but not significantly. GIP and C-peptide both decreased significantly. Glucagon remained essentially unchanged over 12 weeks. RNY rapidly normalizes fasting plasma glucose in morbidly obese patients with DM-II. GIP, a gactor in the enteroinsulin axis, decreases and may play a role in the correction of DM-II after gastric bypass.
The Case for Progesterone (2005)

Recent clinical trials in hormone therapy (HT) for women approaching or past menopause have been disappointing. Most women who have been taking conjugated equine estrogens combined with synthetic progestins have been encouraged to stop these supplements because of increased health risks. The results of the clinical trials may be accurate about the risks associated with the synthetic compounds and combinations, but the data do not reflect what might have been the case if 17beta-estradiol had been tested with natural progesterone instead of synthetic medroxyprogesterone acetate. For the most part, in almost all work on HT, estrogens have been given the primary focus despite the fact that progesterone has important properties that can enhance the repair of neurodegenerative and traumatic injuries to the central nervous system. This article reviews some of those properties and discusses the evidence suggesting that, if HT is to be reconsidered, progesterone should be given more attention as a potent neurotrophic agent that may play an important role in reducing or preventing motor, cognitive, and sensory impairments that can accompany senescence in both males and females.
Electrokinetics of the silica-solution interface: a flat plate streaming potential study (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrokinetics of the silica-solution interface: a flat plate streaming potential studyPeter J. Scales, Franz Grieser, Thomas W. Healy, Lee R. White, and Derek Y. C. ChanCite this: Langmuir 1992, 8, 3, 965–974Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/la00039a037https://doi.org/10.1021/la00039a037research-articleACS PublicationsRequest reuse permissionsArticle Views1875Altmetric-Citations267LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermotropic copolyesters. III. Synthesis and characterization of liquid crystal copolyesters containing the bicyclo[2.2.2]octane ring system (1988)

Abstract A number of thermotropic copolyesters which contain the bicylo[2.2.2]octane ring system have been synthesized. Because of the stiffening effect of the bicyclo[2.2.2]octane group on the chain, the sebacoyl spacer was used to obtain meltable compositions.
Design of a quasi-passive knee exoskeleton to assist running (2008)

In this paper we describe the design and preliminary evaluation of an energetically-autonomous powered knee exoskeleton to facilitate running. The device consists of a knee brace in which a motorized mechanism actively places and removes a spring in parallel with the knee joint. This mechanism is controlled such that the spring is in parallel with the knee joint from approximately heel-strike to toe-off, and is removed from this state during the swing phase of running. In this way, the spring is intended to store energy at heel-strike which is then released when the heel leaves the ground, reducing the effort required by the quadriceps to exert this energy, thereby reducing the metabolic cost of running.
Multiple pleural biopsy with the Abrams needle. (1980)

Multiple pleural biopsies (up to 10) were taken with the Abrams needle through a single aspiration site in 55 patients with pleural effusions. A definite positive or suggestive pleural biopsy diagnosis was made in 33 patients (60%). In 32 of the 33 patients the pathological abnormality was confined to only a proportion of the biopsies. Pleural biopsies were positive or suggestive in 26 out of 36 patients (72%) eventually shown to have tumour and seven out of eight patients (88%) with tuberculosis. Small pneumothoraces occurred in four patients and surgical emphysema in two.
Top-emitting quantum dots light-emitting devices employing microcontact printing with electricfield-independent emission (2016)

Recent breakthroughs in quantum dot light-emitting devices (QD-LEDs) show their promise in the development of next-generation displays. However, the QD-LED with conventional ITO-based bottom emission structure is difficult to realize the high aperture ratio, electricfield-independent emission and flexible full-color displays. Hence, we demonstrate top-emitting QD-LEDs with dry microcontact printing quantum dot films. The top-emitting structure is proved to be able to accelerate the excitons radiative transition rate, then contributing to stable electroluminescent efficiency with a very low roll-off, and preventing spectra from shifting and broadening with the electric field increases. The results suggest potential routes towards creating high aperture ratio, wide color gamut, color-stable and flexible QD-LED displays.
NOTICES (1970)

Journal Article NOTICES Get access AVERSION THERAPY AND BEHAVIOUR DISORDERS: AN ANALYSIS. By S. RACHMAN and J. TEASDALE. [London: Routledge and Kegan Paul. 1969. 174 pp. 40s.] P. D. S. P. D. S. Search for other works by this author on: Oxford Academic Google Scholar The British Journal of Criminology, Volume 10, Issue 1, January 1970, Page 90, https://doi.org/10.1093/oxfordjournals.bjc.a046223 Published: 01 January 1970
Antisense suppression of the <i>Arabidopsis PIF3</i> gene does not affect circadian rhythms but causes early flowering and increases <i>FT</i> expression (2003)

Photoperiodic control of flowering is regulated by light and a circadian clock. Feedback regulation of the transcription of clock components is one of the most common and important mechanisms that control clock functions in animals, fungi, and plants. The Arabidopsis circadian clock is believed to involve two myb-related proteins, LHY (late elongated hypocotyl) and CCA1 (circadian clock associated 1), which negatively regulate TOC1 (timing of cab expression 1) gene expression through direct binding to the TOC1 promoter. PIF3 (phytochrome-interacting factor 3), a bHLH transcription factor binds promoter regions of the LHY and CCA1 genes, affecting the light induction of these genes, and interacts with TOC1 protein. Although the positive feedback regulation of clock components in plants has been predicted, and PIF3 has been assumed to be involved, the molecular nature of this process has not been elucidated. Here we demonstrate that the antisense suppression of the PIF3 gene causes higher levels of mRNA of floral activator genes CO (constans) and FT (flowering locus T) and results in early flowering under long days (LD). Neither the circadian rhythms of the clock-controlled genes (CCGs) under constant conditions nor the diurnal rhythms of the CCGs under LD conditions are affected by the reduction in PIF3 gene expression. These results suggest that PIF3 may play an important role in the control of flowering through clock-independent regulation of CO and FT gene expression in Arabidopsis.
Whole-genome sequencing in an autism multiplex family (2013)

Our study represents one of the first whole-genome sequencing studies in autism leveraging a large family-based pedigree. These results provide for a discussion on the relative merits of finding de-novo mutations in sporadic cases versus finding inherited mutations in large pedigrees, in the context of neuropsychiatric and neurodevelopmental diseases.
Wearable and wireless accelerometer systems for monitoring Parkinson’s disease patients—A perspective review (2013)

Parkinson’s disease is a growing medical concern as societies, such as the United States of America, become progressively aged. Therapy strategies exist for the amelioration of Parkinson’s disease symptoms, and the quantification of attributes, such as hand tremor, can provide valuable feedback. Wearable and wireless accelerometer systems for monitoring Parkinson’s disease patients have been progressively advanced over the course of the past half-decade. In particular, wireless accelerometer nodes and smartphones, such as the iPhone, hold promise for optimizing therapy strategy by providing convenient quantified feedback. This perspective review addresses the current advances in wearable and wireless accelerometer systems for monitoring Parkinson’s disease patients and forecasts for the near future.
Free ultra-high-Q microtoroid: a tool for designing photonic devices (2007)

We describe techniques that enable fabrication of a new class of photonic devices based on free UH-Q microresonators. Preliminary results show that free silica microtoroids with Qs above 30 million can be fabricated and transferred to different platforms for integration with a variety of photonic devices.
Prolonged Intercostal Nerve Blockade in Sheep Using Controlled-release of Bupivacaine and Dexamethasone from Polymer Microspheres  (1998)

A single administration of bupivacaine-dexamethasone microspheres produces an effective chest wall analgesia of several days' duration. This may prove useful clinically for thoracic surgery or trauma.
Multi-dimensional multiple hypothesis tracking with a Gaussian mixture model to suppress grating lobes (2017)

A new approach for multi-target tracking under grating lobe environment is presented. Ambiguous angle measurements are obtained by a wide-array antenna whose elements have a long interval. Angle measurements different from the true target angles are obtained because of the grating lobes; therefore, it is difficult to initialize and maintain target tracking accurately. In this paper, we propose a multi-dimensional multiple hypothesis tracking method using a Gaussian mixture model, which is an extension of multiple hypothesis tracking for multiple targets. The proposed method assumes distribution of angle measurement error including grating lobes as a Gaussian mixture model. From this assumption, combinations of measurements, tracks, and Gaussian components are generated as a three-dimensional (3-D) hypothesis. The algorithm finds multiple measurement-to-track-to-grating hypotheses from a 3-D association matrix efficiently. Simulations are performed to demonstrate the effectiveness of the proposed algorithms.
Chemical Modification of the Inner and Outer Surfaces of Tobacco Mosaic Virus (TMV) (2013)

Viral nanoparticles derived from tobacco mosaic virus (TMV) find applications in various fields. We report the purification and chemical modification of TMV which is a hollow rod-shaped plant viral nanoparticle with modifiable interior and exterior surfaces. We describe methods to isolate TMV from its tobacco plant host for spatially controlled interior and exterior chemical modification and to characterize the resulting TMV hybrid materials.
Structure and Sequence of the Centromeric DNA of Chromosome 4 in <i>Saccharomyces cerevisiae</i> (1986)

The CEN4 sequences from chromosome 4 that impart mitotic stability to autonomously replicating (ARS) plasmids in yeast cells have been localized to a 1,755-base-pair (bp) fragment. This fragment could be cut in half to give two adjacent, nonoverlapping fragments, that each contained some mitotic stabilization sequences. One of the half-fragments worked as efficiently as the larger fragment from which it was derived, while the other half provided a much poorer degree of mitotic stabilization. Sequencing of 2,095 bp of DNA including this region revealed the presence of a centromere consensus sequence, elements I, II, and III (M. Fitzgerald-Hayes, L. Clarke, and J. Carbon, Cell 29:235-244, 1982), in the half-fragment providing high levels of mitotic stability. The poorly stabilizing half-fragment did not contain any obvious sequence homologies to other centromere sequences. Deletion analysis of the 1,755-bp fragment indicated that removal of the 14-bp element I plus 16 of the 82 bp of element II impaired mitotic stability. Removal of elements I and II eliminated the mitotic stability provided by the consensus sequence.
The future of interactive systems and the emergence of direct manipulation† (1982)

Abstract This paper suggests three motivations for the strong interest in human factors' aspects of user interfaces and reviews five design issues: command language versus menu selection, response time and display rates, wording of system messages, on-line tutorials, explanations and help messages and hardware devices. Five methods and tools for system development are considered: participatory design, specification methods, software implementation tools, pilot studies and acceptance tests and evolutionary refinement based on user feedback. The final portion of the paper presents direct manipulation, an approach which promises to become widely used in interactive systems. Direct manipulation involves representation of the object of interest, rapid incremental reversible actions and physical action instead of complex syntax.
Unique 3D CoII/ZnII-coordination polymers with (3,4,5)-connected self-penetrating topology: Syntheses, topological structures, luminescent and magnetic properties (2012)

Under solvothermal conditions, the reactions of CoII or ZnII acetate with mixed-ligand 3-(pyridin-4-yl)-5-(pyrazin-2-yl)-1H-1,2,4-triazole (4-Hpzpt) and isophthalate (H2ip) afford two isomorphic compounds [M3(ip)2(4-pzpt)2(H2O)]n (M = CoII (1), ZnII (2)), which display a new hepta-nodal (3,4,5)-connected self-penetrating net assembled from 2D {[M3(4-pzpt)2]4+}n 63-hcb layers pillared by [M6(ip)4(H2O)2]4+ subunits, and show antiferromagnetic behavior for 1 and strong fluorescence for 2, respectively.
Advanced three‐dimensional tailored RF pulse for signal recovery in <i>T</i><sub>2</sub>*‐weighted functional magnetic resonance imaging (2006)

T(2) (*)-weighted functional MR images are plagued by signal loss artifacts caused by susceptibility-induced through-plane dephasing. We present major advances to the original three-dimensional tailored RF (3DTRF) pulse method that pre-compensates the dephasing using three-dimensional selective excitation. The proposed 3DTRF pulses are designed iteratively with off-resonance incorporation and with a novel echo-volumar trajectory that frequency-encodes in z and phase-encodes in x,y. We also propose a computational scheme to accelerate the pulse design process. We demonstrate effective signal recovery in a 5-mm slice in both phantom and inferior brain, using 3DTRF pulses that are only 15.4 ms long. Compared to the original method, the new approach leads to significantly reduced pulse length and enhancement in slice selectivity. 3D images of the slice volume confirm fidelity of the excited phase pattern and slice profile.
DYNAMIC RANGE LIMITATIONS OF LOW-NOISE MICROWAVE TRANSISTORS AT CRYOGENIC TEMPERATURES (2021)

More than 70% of women do not gain within their target range of gestational weight gain (GWG), as recommended by the Institute of Medicine (IOM) in 2009. Risks associated with inadequate GWG include small-for-gestational age, low birthweight, pre-term birth, and difficulty establishing breastfeeding. Risks associated with excessive GWG include large-for-gestational-age, macrosomia, and delivery complications. There are also long-term consequences for maternal and fetal metabolic processes. Higher pre-pregnancy BMI, lower education level, and higher parity are known risk factors for excessive GWG. There are also possible racial / ethnic differences, and Hispanic women, in particular, may be at high risk for excessive GWG. Thus, the research aim was to examine multiple measures of GWG prospectively, including potentially modifiable risk factors for and consequences of GWG outside IOM recommendations among pregnant Hispanic women in Proyecto Buena Salud (PBS), a prospective cohort study. Chapter 1 examines the association between stress / anxiety in early, mid- and late pregnancy and GWG. Among 1308 Hispanic women, high stress in early pregnancy was associated with lower total GWG; high stress in late pregnancy was associated with lower rate of GWG; and high anxiety in early pregnancy was associated with both lower rate of GWG and lower total GWG. Chapter 2 examines the association between GWG and cesarean delivery. Among 1215 Hispanic women, each additional pound of GWG was associated with a 2% greater risk of cesarean delivery. Rate of GWG was also positively associated with the risk of cesarean delivery. Chapter 3 examines the association between GWG and abnormal glucose tolerance (AGT) / gestational diabetes mellitus (GDM). Among 1277 Hispanic women, GWG was inversely associated AGT, but not significantly associated with GDM. Specifically, excessive GWG until the GDM screen was associated with a 35% lower risk of AGT. This association was only significant among women with normal pre-pregnancy BMI. In conclusion, stress and anxiety were inversely associated with GWG, and GWG was positively associated with cesarean delivery and inversely associated with AGT (among women with normal pre-pregnancy BMI). These projects contribute to an understanding of the correlates and consequences of GWG at various points throughout pregnancy.