gebhart/patrepeval huggingface dataset:
Advanced signal processing methods for pulsed laser vibrometry (2010)

Although pulsed coherent laser radar vibrometry has been introduced as an improvement over its continuous wave (CW) counterpart, it remains very sensitive to decorrelation noises, such as speckle, and other disturbances of its measurement. Taking advantage of more polyvalent polypulse waveforms, we address the issue with advanced signal processing. We have conducted what we believe is the first extensive comparison of processing techniques considering CW, pulse-pair, and polypulse emissions. In this framework, we introduce a computationally efficient maximum likelihood estimator and test signal tracking on pseudo-time-frequency representations (TFRs), which, respectively, help deal with speckle noise and fading of the signal in harsh noise conditions. Our comparison on simulated signals is validated on a 1.55 microm all-fiber vibrometer experiment with an apparatus simulating vibration and strong speckle noise. Results show the advantage of the estimators that take into account actual noise statistics, and call for a wider use of TFRs to track the vibration-modulated signal.
Idiopathic Pulmonary Fibrosis: Impact of Oxygen and Colchicine, Prednisone, or No Therapy on Survival (2000)

The clinical records of 487 patients seen at Mayo Clinic Rochester (MCR) during 1994 through 1996 who were diagnosed as having idiopathic pulmonary fibrosis of the usual interstitial pneumonia type (IPF/UIP) were reviewed. Computed tomography (CT) had been done in 94.7% of patients and surgical open lung biopsy (OLB) in 20.3%. Median survival was 3.2 yr. We compared survival as a function of treatment program, based on intent to treat at the time of the initial contact within the study window. Treatment advised included colchicine alone in 167, no therapy in 157, prednisone at maintenance dosages alone in 54, colchicine plus prednisone in 71, and other programs in 38. Oxygen therapy was advised in 133 patients. By univariate analysis, worse survival was associated with prednisone therapy compared with no therapy, and with oxygen therapy compared with no oxygen therapy. However, on multivariate analysis, worse survival was associated with older age, male gender, lower diffusing capacity for carbon monoxide (DL(CO)), lower alveolar volume (VA), and a history of worsening pulmonary function. When adjustment was made for these factors, there was no significant difference in survival between those patients treated with colchicine or prednisone and those on no therapy, and no difference between those on oxygen therapy and those without oxygen.
Short-Term Outcome Analysis of Total Pelvic Reconstruction With Mesh:: The Vaginal Approach (2004)

Transvaginal technique of 4-point vaginal vault fixation using mesh is a safe and effective procedure at 2 years.
Effects of vibration and hyaluronic acid on activation of three‐dimensional cultured chondrocytes (2006)

Our results indicate that the combination of vibration and HA activates the production of proteoglycan in 3-dimensional cultured chondrocytes and stimulates MAPK and beta-catenin. This suggests that some mechanoreceptors for vibration exist on the plasma membrane of chondrocytes and activate the intracellular signal transduction system.
The Effects of Temperature and Relative Humidity on the Viability of the SARS Coronavirus (2011)

The main route of transmission of SARS CoV infection is presumed to be respiratory droplets. However the virus is also detectable in other body fluids and excreta. The stability of the virus at different temperatures and relative humidity on smooth surfaces were studied. The dried virus on smooth surfaces retained its viability for over 5 days at temperatures of 22–25°C and relative humidity of 40–50%, that is, typical air-conditioned environments. However, virus viability was rapidly lost (>3 log 10 ) at higher temperatures and higher relative humidity (e.g., 38°C, and relative humidity of >95%). The better stability of SARS coronavirus at low temperature and low humidity environment may facilitate its transmission in community in subtropical area (such as Hong Kong) during the spring and in air-conditioned environments. It may also explain why some Asian countries in tropical area (such as Malaysia, Indonesia or Thailand) with high temperature and high relative humidity environment did not have major community outbreaks of SARS.
Endoscopic Doppler ultrasound after injection therapy for peptic ulcer hemorrhage. (2004)

A negative endoscopic Doppler status immediately after injection therapy is not helpful to identify patients with no risk for rebleeding from peptic ulcer.
Algorithms for Optimizing Leveled Commitment Contracts (1999)

In automated negotiation systems consisting of self-interested agents, contracts have traditionally been binding. Leveled commitment contracts - i.e. contracts where each party can decommit by paying a predetermined penalty - were recently shown to improve Pareto efficiency even if agents rationally decommit in Nash equilibrium using inflated thresholds on how good their outside offers must be before they decommit. This paper operationalizes the four leveled commitment contracting protocols by presenting algorithms for using them. Algorithms are presented for computing the Nash equilibrium decomitting thresholds and decommitting probabilities given the contract price and the penalties. Existence and uniqueness of the equilibrium are analyzed. Algorithms are also presented for optimizing the contract itself (price and penalties). Existence and uniqueness of the optimum are analyzed. Using the algorithms we offer a contract optimization service on the web as part of eMediator, our next generation electronic commerce server. Finally, the algorithms are generalized to contracts involving more than two agents.
Experimental phycology : a laboratory manual (1988)

Writing a Laboratory report, C.S.Lobban algal cultures, E.C.Henry cell counting, S.Schoen phytoplankton stains, P.J.Harrison biomass measurements - protein determination P.J.Harrison and T.E.Thomas spectrophotometric and fluorometric chlorophyll analysis, N.Sterman water quality assessment, M.A.Leupold Selenastrum capricornutum printz algal assay - bottle test for determination of limiting nutrient status, D.J.Rawlence photosynthesis and respiration of aquatic macroflora using the light and dark bottle oxygen method and dissolved oxygen analyser, M.L.H.Thomas Appendix - the Winkler procedure for measurement of dissolved oxygen, C.J.Dawes adaption to high and low irradiances measured by photosynthetic rate, P.J.Harrison quantitative analysis of pigments, D.J.Chapman formation and analysis of secondary carotenoids, D.J.Chapman electrophoretic separation and spectral characterization of algal phycobiliproteins, B.P.Kremer.
Calcium Phosphate Cement: Review of Mechanical and Biological Properties (2006)

Further research is necessary to understand and improve the behavior of this type of cement under clinical situations.
Markers of senescence? (2002)

The specific identification of cellular senescence in clinical material has important implications for determining the role of senescence in age-related pathologies and in neoplasia in certain tumours. One suggested marker of senescence is the histochemical identification of a specific beta-galactosidase enzyme operative at pH 6.0. However, recent data indicate that this enzyme may not be specific for senescence in all tissues and probably represents the expression of endogenous lysosomal acid beta-galactosidase, which is expressed by a variety of differentiated cell types.
Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47–SHPS-1 system (2008)

CD47 and SHPS-1 are transmembrane proteins that interact with each other through their extracellular regions and constitute a bidirectional cell-cell communication system (the CD47-SHPS-1 system). We have now shown that the trans-interaction of CD47 and SHPS-1 that occurred on contact of CD47-expressing CHO cells and SHPS-1-expressing CHO cells resulted in endocytosis of the ligand-receptor complex into either cell type. Such trans-endocytosis of CD47 by SHPS-1-expressing cells was found to be mediated by clathrin and dynamin. A juxtamembrane region of SHPS-1 was indispensable for efficient trans-endocytosis of CD47, which was also regulated by Rac and Cdc42, probably through reorganization of the actin cytoskeleton. Inhibition of trans-endocytosis of CD47 promoted the aggregation of CD47-expressing cells with the cells expressing SHPS-1. Moreover, CD47 expressed on the surface of cultured mouse hippocampal neurons was shown to undergo trans-endocytosis by neighboring astrocytes expressing endogenous SHPS-1. These results suggest that trans-endocytosis of CD47 is responsible for removal of the CD47-SHPS-1 complex from the cell surface and hence regulates the function of the CD47-SHPS-1 system, at least in neurons and glial cells.
Road adaptive active suspension design using linear parameter-varying gain-scheduling (2002)

This paper presents a novel approach to the design of road adaptive active suspensions via a combination of linear parameter-varying control and nonlinear backstepping techniques. Two levels of adaptation are considered: the lower level control design shapes the nonlinear characteristics of the vehicle suspension as a function road conditions, while the higher level design involves adaptive switching between these different nonlinear characteristics, based on the road conditions. A quarter car suspension model with a nonlinear dynamic model of the hydraulic actuator is employed. The suspension deflection, car body acceleration, hydraulic pressure drop, and spool valve displacement are used as feedback signals. Nonlinear simulations show that these adaptive suspension controllers provide superior passenger comfort over the whole range of road conditions.
Algorithm-based diskless checkpointing for fault tolerant matrix operations (2002)

The paper is an exploration of diskless checkpointing for distributed scientific computations. With the widespread use of the "network of workstations" (NOW) platform for distributed computing, long-running scientific computations need to tolerate the changing and often faulty nature of NOW environments. We present high-performance implementations of several algorithms for distributed scientific computing, including Cholesky factorization, LU factorization, QR factorization, and preconditioned conjugate gradient. These implementations are able to run on PVM networks of at least N processors, and can complete with low overhead as long as any N processors remain functional. We discuss the details of how the algorithms are tuned for fault-tolerance, and present the performance results on a PVM network of SUN workstations, and on the IBM SP2.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Direct and Rapid Modification of a Porcine Xenoantigen Gene (GGTA1) (2006)

The ability to modify animal genomes rapidly at a specific locus would be valuable both for research purposes and in the development of animals suitable for xenotransplantation. In a proof-of-concept study, we used a unique, homology-dependent strand transferase protein called drosophila recombination-associated protein (DRAP) and DNA oligonucleotides to modify the porcine gene encoding alpha 1,3 galactosyl transferase (GGTA1). This gene is responsible for generating xenotransplantation antigens resulting in hyperacute rejection. Pronuclear injection of DRAP and mutant oligonucleotides yielded piglets with heritable, modified alleles of GGTA1 in a direct, rapid and efficient manner. Cells derived from these piglets had markedly reduced alpha 1,3 galactosyl sugar epitopes. The simplicity of this method should permit rapid sequential or simultaneous modification of the various genes encoding or producing antigens that impose limits on xenotransplantation as they are discovered.
On Failure Propagation in Component-Based Software Systems (2008)

Ensuring reliability in component-based software systems (CBSSs) is important for their effective applications in large scale and safety critical systems. However, only few techniques consider failure propagation in system architectures for system reliability assessment. Those techniques focus only on content failure propagation through component interfaces. Therefore, the evaluation of CBSS architectures based on the current techniques fails to consider the impacts of all failure types on system reliability. In this paper, we present a failure propagation analysis technique for CBSSs. We analyze failure propagation based on architectural service routes (ASRs). An ASR is a sequence of components that are connected through interfaces. We discuss the attributes of ASRs with respect to system components and present their impacts on failure propagation and consequently on the reliability of CBSSs. Further analysis determines upper and lower bounds of failure propagation among components and shows some relationships between system reliability and architectural attributes. Our technique is not limited to any failure type, and it considers failure scattering and masking. Therefore, unlike other works, the proposed technique demonstrates more accurate representation of the practical aspect of failure propagation in CBSSs. The technique can also be used to achieve reliable designs in the early design stages of CBSSs and to localize component faults in the operational stage. We compare different example architectures based on their impacts on system reliability.
Local nitric oxide synthase activity in a model of neuropathic pain (1998)

A local inflammatory reaction may play an important role in the development of neuropathic pain following peripheral nerve injury. One important participant in the inflammatory response of injured peripheral nerve may be nitric oxide (NO). In this work, we examined physiological and morphological evidence for nitric oxide synthase (NOS) activation in the chronic constriction injury model of neuropathic pain in rats. Physiological evidence of local NO action was provided by studying NO-mediated changes in local blood flow associated with the injury site. Immunohistochemistry was used to localize isoforms of NOS that might generate NO. Sciatic nerve injury associated with behavioural evidence of neuropathic pain had substantial rises in local blood flow. The NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME), but not NG-nitro-D-arginine methyl ester (D-NAME), reversed the hyperaemia in a dose-dependent fashion proximal to the constriction at 48 h and distally at 14 days post-operation when applied systemically or topically. Aminoguanidine, a NOS inhibitor with relatively greater selectivity for the inducible NOS (iNOS) isoform, reversed nerve hyperaemia distal to the constriction only at 14 days. NOS-like immunoreactivity of the neuronal and endothelial isoforms was identified just proximal to the constriction at 48 h. iNOS-like immunoreactivity was observed at 7 and 14 days at the constriction and distal sites, respectively. This work provides evidence for local NOS expression and NO action in the chronic constriction injury model of neuropathic pain. NO has local physiological actions that include vasodilatation of microvessels and that may be important in the development of pain sensitivity.
Role of the TSG101 Gene in Epstein-Barr Virus Late Gene Transcription (2006)

Rta, an Epstein-Barr virus (EBV)-encoded immediate-early protein, governs the reactivation of the viral lytic program by transactivating a cascade of lytic gene expression. Cellular transcription factors such as Sp1, ATF2, E2F, and Akt have been demonstrated to mediate Rta transactivation of lytic genes. We report herein that Rta associates with another potent transcription factor, tumor susceptibility gene 101 (TSG101), to promote the activation of EBV late genes. Results from an EBV cDNA array reveal that depletion of TSG101 by siRNA potently inhibits the transcription of five Rta-responsive EBV late genes, BcLF1, BDLF3, BILF2, BLLF1, and BLRF2. Depletion of TSG101 impairs the Rta transactivation of these late promoters severely. Moreover, a concordant augmentation of Rta transactivating activity is observed when TSG101 is overexpressed following ectopic transfection. Mechanistically, Rta interaction with TSG101 causes the latter to accumulate principally in the nuclei, wherein the proteins colocalize and are recruited to the viral promoters. Of note, TSG101 is crucial for the efficient binding of Rta to these late promoters. As a result, cells with defective TSG101 fail to express late viral proteins, leading to a decrease in the yield of virus particles. Thus, the contribution of TSG101 to Rta-mediated late gene activation is of great importance for completion of the EBV productive lytic cycle. These observations consolidate a role for TSG101 in the replication of EBV, a DNA virus, that differs from what is observed for RNA viruses, where TSG101 aids mainly in the endosomal sorting of enveloped late viral proteins for assembly at the plasma membrane.
Eupatilin protects against tumor necrosis factor-α-mediated inflammation inhuman umbilical vein endothelial cells. (2015)

Inflammatory responses in the blood vessel play a pivotal role in the pathogenesis of atherosclerosis. Eupatilin, a flavone derived from Artemisia princepsPampanini, has various pharmacological activities, including antioxidant, anti-tumor, and anti-inflammatory capacities. However, there has been no research examining the function of eupatilin on vascular inflammation. Therefore, the aim of this study was to investigate the effects of eupatilin on tumor necrosis factor (TNF)-α-induced human umbilical vein endothelial cells (HUVECs) activation and the underlying molecular mechanisms. Our findings showed that eupatilin reduced U937 cells adhesion to TNF-α-stimulated HUVECs and attenuated TNF-α-induced the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) in HUVECs, as well as the production of intracellular reactive oxygen species (ROS). Moreover, eupatilininhibits TNF-α-induced phosphorylation of NF-kB p65 and MAPKs in HUVECs. Taken together, the results of the present study suggest that eupatilin inhibited inflammatory reaction through suppressing the ROS/MAPK-NF-ĸB pathway in HUVECs. Thus, eupatilin is proposed as an effective new anti-inflammatory agent to suppress vascular inflammation, and further prevent atherosclerosis.
Amplification of a DEAD box gene (DDX1) with the MYCN gene in neuroblastomas as a result of cosegregation of sequences flanking the MYCN locus (1996)

A DEAD box gene (DDX1) characterized by a motif with a putative RNA helicase was found at elevated levels, with multiple copies, in a neuroblastoma and in some retinoblastoma cell lines in which the MYCN gene was amplified. The present study was aimed at determining whether amplification of the DDX1 gene is critical for human neuroblastomas exhibiting MYCN gene amplification. Extended DNA panels of tumors and cell lines revealed amplification of the DDX1 gene in approximately half of the specimens exhibiting MYCN gene amplification, which is in good agreement with a finding reported recently. Because its profile was similar to that of the cDNA marker G21 and another flanking DNA marker, clone 8, both of which localize outside the core of the amplicon of the MYCN gene, we noted that we could localize the DDX1 gene in relation to the MYCN gene. Utilizing pulsed-field gel electrophoresis according to a method based on the combinatorial alignment of multiple single digests and a 5.5-megabase map surrounding the MYCN locus, we mapped the DDX1 gene within a 100 kb region about 400 kb upstream from the MYCN gene, where G21 is localized. Further hybridization experiments with both genes, complete sequencing of G21, and its comparison with that of the DDX1 gene eventually confirmed that the DDX1 gene is identical to G21. G21 is a cDNA clone isolated by differential screening of a library from a neuroblastoma cell line, IMR-32, but its function has not yet been identified. Coamplification of the DDX1 gene with the MYCN gene is a consequence of the segregation of continuous DNA stretches spanning both loci during the amplification process. Genes Chromosom Cancer 15:129–133 (1996). © 1996 Wiley-Liss, Inc.
Molecular sieve encapsulated organic dyes and metal chelates (1994)

Inorganic molecular sieves have a well‐defined internal structure of uniform cages, cavities, or channels–see the Figure for an example–making them suitable for many applications. Recently the inclusion of dyes and metal chelates as guests has been studied. The results are reviewed briefly, including the preparation and characterization of the host/guest system and the chemical reactivity. magnified image
Epac2 Mediates Cardiac β1-Adrenergic–Dependent Sarcoplasmic Reticulum Ca <sup>2+</sup> Leak and Arrhythmia (2013)

β(1)-AR activates Epac2 to induce SR Ca(2+) leak via CaMKIIδ-dependent phosphorylation of RyR2-S2814. This pathway contributes to β-AR-induced arrhythmias and reduced cardiac function.
Small molecule inhibitors of PTP1B and TCPTP (2012)

Fragment based drug design is a new approach in identifying the initial chemical starting point for drug discovery programs. Fragment based drug design allows screening of a substantial number of compounds usually hundred - thousand compounds. It identifies fragments which binds specifically but with low affinity in the range of 0.1-10mM.The small sized fragments make the subsequent optimization is relatively easier to build the molecule by exploring the chemical space in the binding pocket.The virtual screening study of small molecule compounds from a chemical library was carried out and selected few molecules as inhibitors of PTP1B/TCPTP. These molecules were tested by in-vitro biochemical assay and were inhibiting both PTP1B and TCPTP.
Analysis and classification of EEG signals using spectral analysis and recurrent neural networks (2010)

This study proposes a three stages technique for automatic detection of epileptic seizure in EEG signals. In practical application of pattern recognition, there are often diverse features extracted from raw data which needs to be recognized. Proposed method is based on time series signal, spectral analysis and recurrent neural networks (RNNs). Decision making was performed in three stages:(i)feature extraction using Welch method power spectrum density estimation (PSD) (ii)dimensionality reduction using statistics over extracted features and time series signal samples (iii)EEG classification using recurrent neural networks. This study shows that Welch method power spectrum density estimation is an appropriate feature which well represents EEG signals. We achieved higher classification accuracy (specificity, sensitivity, classification accuracy) in comparison with other researches to classify EEG signals exactly 100% in this study.