gebhart/patrepeval huggingface dataset:
Conversion of Adipose-Derived Stem Cells into Natural Killer-Like Cells with Anti-Tumor Activities in Nude Mice (2014)

Efforts to develop peripheral blood-derived nature killer (NK) cells into therapeutic products have been hampered by these cells' low abundance and histoincompatibility. On the other hand, derivation of NK-like cells from more abundant cell sources such as embryonic stem cells (ESCs) and umbilical cord blood (UCB) requires the selection of rare CD34+ cells. Thus, we sought to convert adipose-derived stem cells (ADSCs), which are abundant and natively CD34+, into NK-like cells. When grown in hematopoietic induction medium, ADSCs formed sphere clusters and expressed hematopoietic markers CD34, CD45, and KDR. Further induction in NK cell-specific medium resulted in a population of cells that expressed NK cell marker CD56, and thus termed ADSC-NK. Alternatively, the hematopoietically induced ADSCs were transduced with NK cell-specific transcription factor E4BP4 prior to induction in NK cell-specific medium. This latter population of cells, termed ADSC-NKE, expressed CD56 and additional NK cell markers such as CD16, CD94, CD158, CD314, FasL, and NKp46. ADSC-NKE was as potent as NK leukemia cell NKL in killing breast cancer cell MCF7 and prostate cancer cells DU145, PC3, LnCap, DuPro, C4-2 and CWR22, but exhibited no killing activity toward normal endothelial and smooth muscle cells. In nude mice test ADSC-NKE was able to significantly delay the progression of tumors formed by MCF7 and PC3. When injected into immunocompetent rats, ADSC-NKE was detectable in bone marrow and spleen for at least 5 weeks. Together, these results suggest that ADSCs can be converted into NK-like cells with anti-tumor activities.
Evaluation of Fatigue Damage by X-Ray Diffraction Technique of Steam Turbine Rotor Steels at Elevated Temperatures (2009)

In many industrial applications materials are subjected to degradation of mechanical properties as a result of real service conditions. The assessment of the remaining lifetime of components and structures is commonly based on correlated procedures including numerous destructive, non-destructive and mathematical techniques that should guarantee reasonable precise assessment of the current damage extent of materials in question and the remnant lifetime assessment. The assessment of the remaining lifetime by X-ray diffraction technique is based on the fact that mechanical properties of the most materials depend strongly on crystallite size and orientation of ingredients, which are the crucial parameters for the determination of the ageing state and the prediction of residual lifetime of the components. X-ray diffraction technique proved to be useful as a tool for the assessment of material degradation extent after a long-time service. Framework 5 project “XPECTION” [1] was dealing with this task with respect to high temperature creep degradation of boiler tube steels. In this presentation, the X-ray diffraction technique was applied to reveal subtle details of the microstructural changes induced by fatigue. Several steam turbine rotor steels were fatigue tested at elevated temperatures up to 600°C at strain control regime. After the tests, the X-ray diffraction method was used to correlate the extent of fatigue damage with the X-Ray diffraction patterns to be able to assume the life-time exhaustion caused by fatigue loading in service.
Outlier detection in heart rate signal using activity information (2012)

During exercise, heart rate will increase and its distribution will be different from that in stationary statement. Moreover, activity introduces several outliers into heart rate series. Heart rate variability analysis under exercise conditions can't be conducted identically to the traditional methods. A heart rate distribution analysis method is proposed to fuse the activity information and heart rate signals which will be used to make heart rate analysis under exercise conditions. Firstly we use Gaussian function to fit RR intervals under various intensity activities, and then establish dynamic model for the parameter μ and σ which is changed with activity intensity. With the distribution of heart rate determined, outliers in RR interval can be detected and replaced according to possibility distribution. In the last, the validity of outlier detection algorithm and the influence of outliers to HRV are verified.
Successful treatment of decompensated chronic viral hepatitis by bursal disease virus vaccine. (1999)

Three cases of women with chronic liver inflammation caused by hepatitis B (two) and C (one) viral infections, were followed up to twelve years after diagnosis. As conventional therapy was ineffective and the patients progressed into decompensated liver disease, they were superinfected with massive doses of an attenuated variant (MTH-68/B) of the apathogenic avian Bursal Disease virus (a double-stranded RNA virus from the Birnaviridae family). Clinical symptoms and biochemical abnormalities were resolved in two patients following few months of virus treatment. Cirrhosis was stabilized and significant clinical improvement was achieved in the third patient--who before the virus therapy was moribund with recurring, diuretic-resistant ascites, variceal bleedings, portal encephalopathy and renal failure. To our knowledge, these are the first recorded cases of decompensated chronic viral hepatitis which went to long-lasting remission or were stabilized by superinfection with an apathogenic virus.
Tailoring Onion Routing to the Internet of Things: Security and Privacy in Untrusted Environments (2019)

An increasing number of IoT scenarios involve mobile, resource-constrained IoT devices that rely on untrusted networks for Internet connectivity. In such environments, attackers can derive sensitive private information of IoT device owners, e.g., daily routines or secret supply chain procedures, when sniffing on IoT communication and linking IoT devices and owner. Furthermore, untrusted networks do not provide IoT devices with any protection against attacks from the Internet. Anonymous communication using onion routing provides a well-proven mechanism to keep the relationship between communication partners secret and (optionally) protect against network attacks. However, the application of onion routing is challenged by protocol incompatibilities and demanding cryptographic processing on constrained IoT devices, rendering its use infeasible. To close this gap, we tailor onion routing to the IoT by bridging protocol incompatibilities and offloading expensive cryptographic processing to a router or web server of the IoT device owner. Thus, we realize resource-conserving access control and end-to-end security for IoT devices. To prove applicability, we deploy onion routing for the IoT within the well-established Tor network enabling IoT devices to leverage its resources to achieve the same grade of anonymity as readily available to traditional devices.
The fast multipole method for the wave equation: a pedestrian prescription (1993)

A practical and complete, but not rigorous, exposition of the fact multiple method (FMM) is provided. The FMM provides an efficient mechanism for the numerical convolution of the Green's function for the Helmholtz equation with a source distribution and can be used to radically accelerate the iterative solution of boundary-integral equations. In the simple single-stage form presented here, it reduces the computational complexity of the convolution from O(N/sup 2/) to O(N/sup 3/2/), where N is the dimensionality of the problem's discretization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The tumor-suppressive and potential therapeutic functions of miR-34a in epithelial carcinomas (2015)

The potential of miRNAs to be developed into anti-cancer therapeutics has become an increasingly important area of research. miR-34a is a tumor suppressive miRNA across many tumor types through its ability to inhibit cellular proliferation, invasion and tumor sphere formation. miR-34a also shows promise within certain in vivo solid tumor models. Finally, as miR-34a moves into clinical trials it will be important to determine if it can further sensitize tumors to certain chemotherapeutic agents.
A Novel Approach for Boosting Base Station Anonymity in a WSN (2017)

Nodes in a wireless sensor network scrutinize the nearby region and transmit their findings to the base station (BS) using multi-hop transmission. As the BS plays an important role in a wireless sensor network, therefore an adversary who wants to interrupt the operation of the network would avidly look for the BS location and imposes maximum damage by destroying the BS physically. The multi-hop data transmission towards BS makes a prominent pattern of the traffic (huge traffic near the BS region) that indicates the presence of BS in the nearby region and thus the location of the BS may expose to the adversaries. This work aims to provide a novel approach which will increase the BS anonymity. For this purpose, a randomly roamed BS and the special nodes are proposed to achieve the above mentioned objective. The special nodes produce a large number of high traffic regions, which are similar to the BS region. Now, there are many regions which look like BS region and hence the probability to get the BS region using traffic analysis is very low. Therefore, this approach increases the effort of adversaries in order to find the exact BS position. We have used a standard entropy model to measure the anonymity of the base station and the GSAT test is used to calculate the number of steps required to find the base station. The results show that the proposed technique provides better results in terms of anonymity compared to the existing techniques.
Tutela cautelar e tutela antecipada : distinções fundamentais (1998)

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Inhibition of Protein Aggregation: Supramolecular Assemblies of Arginine Hold the Key (2007)

Based on our experimental results we propose that molecular clusters of arginine in aqueous solutions display a hydrophobic surface by the alignment of its three methylene groups. The hydrophobic surfaces present on the proteins interact with the hydrophobic surface presented by the arginine clusters. The masking of hydrophobic surface inhibits protein-protein aggregation. This mechanism is also responsible for the hydrotropic effect of arginine on various compounds. It is also explained why other amino acids fail to inhibit the protein aggregation.
Could valproic acid be an effective anticancer agent? The evidence so far (2014)

Valproic acid is an inhibitor of class I histone deacetylases. Epigenetic therapies in cancer have been focus of a keen interest and histone deacetylase inhibitors, in particular, have been approved for certain types of hematologic malignancies. Valproic acid is an attractive candidate for cancer therapy due to its mechanism of action, its low cost and generally good clinical tolerability. In the following editorial, we will review its role as monotherapy for cancer, its place in combination epigenetic therapy, and its role as chemosensitizer, and cancer preventative agent.
Using Ecological Whole Body Kinematics to Evaluate Effects of Medication Adjustment in Parkinson Disease (2014)

This study provided a method of extracting clinically meaningful reports from ecological kinematic data showing changes after drug adjustments. The results are presented using a novel concept called change space that may be more understandable for clinical staff.
Effect of Interferon on Heterotopic New Bone Formation in Mice (1984)

To study the effect of interferon (IFN) on bone induction and new bone formation, heterotopic bone was induced by implanting pieces of demineralized bone matrix in soft tissue of mice. Mouse IFN was given as daily subcutaneous injections of 2 X 10(5) IU/mouse. Treatment was started one week before bone matrix implantation and continued until sacrifice. As a measure of chondrogenesis in the implants short-term incorporation of 35sulphur administered 11 days after implantation was measured. The amount of mineralized tissue formed in connection with the implant was estimated by 45calcium incorporation 20 days after implantation. There was no indication of a negative effect of IFN on bone induction, new bone formation, or metabolism of orthotopic bone. This is in agreement with our findings in the clinical use of IFN after reconstructive surgery in osteosarcoma.
A holistic metrology approach: multi-channel scatterometry for complex applications (2011)

Improvement in metrology performance when using a combination of multiple optical channels vs. standard single optical channel is studied. Two standard applications (gate etch 4x and STI etch 2x) are investigated theoretically and experimentally. The results show that while individual channels might have increased performance for few individual parameters each - it is the combination of channels that provides the best overall performance for all parameters.
The role of apical cell–cell junctions and associated cytoskeleton in mechanotransduction (2017)

Tissues of multicellular organisms are characterised by several types of specialised cell-cell junctions. In vertebrate epithelia and endothelia, tight and adherens junctions (AJ) play critical roles in barrier and adhesion functions, and are connected to the actin and microtubule cytoskeletons. The interaction between junctions and the cytoskeleton is crucial for tissue development and physiology, and is involved in the molecular mechanisms governing cell shape, motility, growth and signalling. The machineries which functionally connect tight and AJ to the cytoskeleton comprise proteins which either bind directly to cytoskeletal filaments, or function as adaptors for regulators of the assembly and function of the cytoskeleton. In the last two decades, specific cytoskeleton-associated junctional molecules have been implicated in mechanotransduction, revealing the existence of multimolecular complexes that can sense mechanical cues and translate them into adaptation to tensile forces and biochemical signals. Here, we summarise the current knowledge about the machineries that link tight and AJ to actin filaments and microtubules, and the molecular basis for mechanotransduction at epithelial and endothelial AJ.
Observer-based backstepping control using online approximation (2000)

This paper extends the applications of neurocontrol approaches to a new class of nonlinear systems diffeomorphic to output feedback nonlinear systems with unmeasured states. A neural-based adaptive observer is introduced for state estimation as well as system identification using only output measurements during online operation. The controller is designed by using the backstepping control design procedure. Nonlinear damping terms are introduced to prevent the instability arising from the state estimation error. The stability analysis for the proposed approach is provided, and the feasibility is investigated by an illustrative example through a numerical simulation.
Improved ``Impregnated Cathode'' (1955)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Roberto Levi; Improved ``Impregnated Cathode''. Journal of Applied Physics 1 May 1955; 26 (5): 639. https://doi.org/10.1063/1.1722057 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioJournal of Applied Physics Search Advanced Search |Citation Search
1,4:3,6-Dianhydrohexitol Nitrate Derivatives. II. Synthesis and Antianginal Activity of Aryl- or Arylcarbonylpiperazine Derivatives. (1993)

A series of 5-(4-aryl- or 4-arylcarbonylpiperazin-1-yl)-5-deoxy-1,4: 3,6-dianhydro-L-iditol 2-nitrates was prepared in order to obtain orally active, nitrate-type vasodilators with reduced side effects. Our drug design was based on a small reduction in the lipophilicity compared to that of 5-deoxy-5-[4-(3-phenylthiopropyl)piperazin-1-yl]-1,4: 3,6-dianhydro-L-iditol 2-nitrate (1, KF14124). Compounds 4h (aryl = benzimidazol-2-yl), 4i (arylcarbonyl = nicotinoyl), and 4w (arylcarbonyl = 3-furoyl) showed potent anti-ischemic activity in a lysine-vasopressin-induced angina pectoris model (rats), and their structure-activity relationships are discussed. Compound 4i exhibited potent vasodilation of the coronary artery in anesthetized dogs and also exhibited potent preload reduction in a heart failure model (dogs) as compared with isosorbide dinitrate (2), nicorandil (3), and KF14124 (1). Furthermore, 4i showed much weaker acute lethal toxicity and less central nervous system depression than 1 in mice. Thus, 4i (KW-3196) is under development as a vasodilator and a drug for treating angina pectoris.
A New Developed Ni-Cr-Mo Alloy with Improved Corrosion Resistance in Flue Gas Desulfurization and Chemical Process Applications (2013)

Abstract Alloy UNS N06058 is a new Ni-21%Cr-19%Mo alloy which has been recently developed. Alloy UNS N06058 is the first Ni-Cr-Mo alloy to contain nitrogen as an alloying constituent. Together with the chromium and the increased molybdenum content the alloying of nitrogen results in a pitting resistance equivalent number (PREN) of about 86, surpassing the nickel-chromium-molybdenum alloys being commonly in use so far. As a result of the specific combination of its alloying constituents the new alloy is featuring an excellent balanced corrosion resistance in oxidizing as well as in reducing environments. In general the new material is characterised by superior resistance to general corrosion in acids and acidic mixtures even when contaminated with chlorides as well as to localised corrosion in regard to all other C-type alloys. Good fabricability including weldability is also given. This work reports on the main properties of alloy UNS N06058 and its suitability for interesting areas of application like flue gas desulfurization and severely corrosive chemical processes.
Striped, Ellipsoidal Particles by Controlled Assembly of Diblock Copolymers (2013)

Control of interfacial interactions leads to a dramatic change in shape and morphology for particles based on poly(styrene-b-2-vinylpyridine) diblock copolymers. Key to these changes is the addition of Au-based surfactant nanoparticles (SNPs) which are adsorbed at the interface between block copolymer-containing emulsion droplets and the surrounding amphiphilic surfactant to afford asymmetric, ellipsoid particles. The mechanism of formation for these novel nanostructures was investigated by systematically varying the volume fraction of SNPs, with the results showing the critical nature that the segregation of SNPs to specific interfaces plays in controlling structure. A theoretical description of the system allows the size distribution and aspect ratio of the asymmetric block copolymer colloidal particles to be correlated with the experimental results.
Selective and enhanced recovery of group A and B streptococci from throat cultures with sheep blood agar containing sulfamethoxazole and trimethoprim (1977)

Sheep blood agar containing 23.75 microgram of sulfamethoxazole and 1.25 microgram of trimethoprim (SXT-BA) per ml was compared with conventional sheep blood agar (SBA) for isolating group A and B streptococci from throat cultures. This selective medium allowed much better recovery of group A and B streptococci and suppressed the growth of the normal flora, including "viridans" streptococci. In an initial study of 700 throat cultures, SXT-BA recovered 42% more group A and 49% more group B streptococci than did SBA. When SXT-BA was introduced into the routine microbiology laboratory and used by a number of medical technologists. SXT-BA recovered 28% more group A and 37% more group B streptococci than did SBA. In addition, the selective medium inhibited 83% of the non-group A and B streptococci that were recovered by SBA.
Hydroformylation of high polymers (1966)

Abstract A new class of polymeric materials has been prepared and subjected to preliminary evaluation. These materials were obtained by hydroformylation of diene‐based polymers. The olefinic bonds were saturated and aldehyde groups attached. magnified image The extent of reaction may be varied at will up to 100% double bond conversion. The properties of these polymers are dominated by the active aldehyde groups. One of the chief characteristics of simple aldehydes is their ability to polymerize forming mainly aldehyde trimers and tetramers. This same phenomenon has been shown to occur with polymeric aldehydes with consequent gel formation. The gelling tendency has been closely related to the aldehyde content per unit volume which may be conveniently varied by ( 1 ) the concentration of the initial polymer, ( 2 ) the degree of unsaturation in the polymer, and ( 3 ) the extent of double bond conversion. Any combination which gives a free aldehyde concentration in excess of 1 × 10 −4 mole/ml. is very prone to gel. The loose gels can be readily reversed by conditions which depolymerize aldehydes. The propensity of the aldehyde polymers to crosslink upon evaporation of the solvent was used to form films. These films were not discolored by ultraviolet light but under such treatment became quite brittle. The products may be stabilized by conversion of the aldehyde groups to more stable derivative, in particular the acetal. The extent of acetal formation has been shown to be controlled by steric factors. Complete polyacetal formation was possible only when the aldehyde groups were well dispersed along the polymer chain. Certain aldehyde derivatives (acetals, oximes) are thermoplastic. They soften at lower temperature than commercial plastics.
Cloning and Nucleotide Sequencing of Two Insecticidal<i>δ</i>- Endotoxin Genes from<i>Bacillus thuringiensis</i>var.<i>kurstaki</i>HD-1 DNA (1987)

Journal Article Cloning and Nucleotide Sequencing of Two Insecticidal δ- Endotoxin Genes from Bacillus thuringiensis var. kurstaki HD-1 DNA Get access Shin-ichi Kondo, Shin-ichi Kondo Department of Biological Chemistry, Toagosei Chemical Industry Co., Ltd., Nagoya 455, Japan Search for other works by this author on: Oxford Academic Google Scholar Nobuya Tamura, Nobuya Tamura Department of Biological Chemistry, Toagosei Chemical Industry Co., Ltd., Nagoya 455, Japan Present address:Michigan Cancer Foundation, Detroit, Michigan, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar Akane Kunitate, Akane Kunitate Department of Biological Chemistry, Toagosei Chemical Industry Co., Ltd., Nagoya 455, Japan Search for other works by this author on: Oxford Academic Google Scholar Masahira Hattori, Masahira Hattori Department of Biological Chemistry, Toagosei Chemical Industry Co., Ltd., Nagoya 455, Japan Present address:Research Laboratory for Genetic Information, Kyushu University, Fukuoka 812, Japan Search for other works by this author on: Oxford Academic Google Scholar Akira Akashi, Akira Akashi Department of Biological Chemistry, Toagosei Chemical Industry Co., Ltd., Nagoya 455, Japan Search for other works by this author on: Oxford Academic Google Scholar Iwao Ohmori Iwao Ohmori Department of Biological Chemistry, Toagosei Chemical Industry Co., Ltd., Nagoya 455, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 51, Issue 2, 1 February 1987, Pages 455–463, https://doi.org/10.1080/00021369.1987.10868034 Published: 01 February 1987 Article history Received: 22 August 1986 Published: 01 February 1987