gebhart/patrepeval huggingface dataset:
Characterization of a monoclonal antibody which detects all murine <i>alpha beta</i> T cell receptors. (1989)

Research on the specificities, functions, and maturation of T cells would be greatly aided by a collection of monoclonal antibodies which distinguishes different types of TCR. With this end in mind hamsters were immunized and tested for production of pan-reactive anti-mouse alpha beta TCR antibodies. In this report we describe the properties and uses of a mAb, H57-597, produced from one of these animals. The mAb reacts with surface receptors on all alpha beta TCR-bearing cells and does not react with receptors on gamma delta+ T cells. In an immobilized form, this antibody can directly activate T cells bearing alpha beta TCR. It can be used in immunoprecipitation reactions to precipitate receptor from the appropriate cell types. In combination with anti-CD3, the antibody can be used in cytofluorographic analyses to measure numbers of CD3+, alpha beta+, and CD3+, gamma delta+ cells in the thymus and periphery.
Tropical Ocean Temperatures Over the Past 3.5 Million Years (2010)

Determining the timing and amplitude of tropical sea surface temperature (SST) change is an important part of solving the puzzle of the Plio-Pleistocene ice ages. Alkenone-based tropical SST records from the major ocean basins show coherent glacial-interglacial temperature changes of 1 degrees to 3 degrees C that align with (but slightly lead) global changes in ice volume and deep ocean temperature over the past 3.5 million years. Tropical temperatures became tightly coupled with benthic delta18O and orbital forcing after 2.7 million years. We interpret the similarity of tropical SST changes, in dynamically dissimilar regions, to reflect "top-down" forcing through the atmosphere. The inception of a strong carbon dioxide-greenhouse gas feedback and amplification of orbital forcing at approximately 2.7 million years ago connected the fate of Northern Hemisphere ice sheets with global ocean temperatures since that time.
Induction of Drug Photosensitization in Man After Parenteral Exposure to Hematoporphyrin (1977)

• Two patients had acute phototoxic reactions after intravenous injections of hematoporphyrin (7 mg/kg) and exposure to light. These reactions were characterized by pain, redness, and swelling of affected sites. Controlled clinical studies were instituted using known types and amounts of light to ascertain the degree of photosensitvity at various time intervals after drug administration. In addition, action spectrum studies elicited a peak response at 405 nm ( ± 5 nm). Plasma hematoporphyrin concentration was approximately 520 μg/100 ml one hour after hematoporphyrin infusion and it gradually declined during a period of 42 days with a biphasic diminution that suggested the existence of at least two pools of hematoporphyrin with half-life decay times of 16 hours and 12 days. βcarotene was administered to ascertain whether or not the phototoxic response could be modified. It is suggested that a degree of protection was obtained that was insufficient to protect the patient. (<i>Arch Dermatol</i>113:1392-1397, 1977)
A new efficient mixture screening design for optimization of media (2009)

Screening ingredients for the optimization of media is an important first step to reduce the many potential ingredients down to the vital few components. In this study, we propose a new method of screening for mixture experiments called the centroid screening design. Comparison of the proposed design with Plackett-Burman, fractional factorial, simplex lattice design, and modified mixture design shows that the centroid screening design is the most efficient of all the designs in terms of the small number of experimental runs needed and for detecting high-order interaction among ingredients.
Regulation of Raf by Akt Controls Growth and Differentiation in Vascular Smooth Muscle Cells (2001)

The stimulation of platelet-derived growth factor (PDGF) receptors shifts vascular smooth muscle (VSM) cells toward a more proliferative phenotype. Thrombin activates the same signaling cascades in VSM cells, namely the Ras/Raf/MEK/ERK and the phosphatidylinositol 3-kinase (PI 3-kinase)/Akt pathways. Nonetheless, thrombin was not mitogenic, but rather increased the expression of the smooth muscle-specific myosin heavy chain (SM-MHC) indicative of an in vitro re-differentiation of VSM cells. A more detailed analysis of the temporal pattern and relative signal intensities revealed marked differences. The strong and biphasic phosphorylation of ERK1/2 in response to thrombin correlated with its ability to increase the activity of the SM-MHC promoter whereas Akt was only partially and transiently phosphorylated. By contrast, PDGF, a potent mitogen in VSM cells, induced a short-lived ERK1/2 phosphorylation but a complete and sustained phosphorylation of Akt. The phosphorylated form of Akt physically interacted with Raf. Moreover, Akt phosphorylated Raf at Ser(259), resulting in a reduced Raf kinase activity and a termination of MEK and ERK1/2 phosphorylation. Disruption of the PI 3-kinase signaling prevented the PDGF-induced Akt and Raf-Ser(259) phosphorylation. Under these conditions, PDGF elicited a more sustained MEK and ERK phosphorylation and increased SM-MHC promoter activity. Consistently, in cells that express dominant negative Akt, PDGF increased SM-MHC promoter activity. Furthermore, expression of constitutively active Akt blocked the thrombin-stimulated SM-MHC promoter activity. Thus, we present evidence that the balance and cross-regulation between the PI 3-kinase/Akt and Ras/Raf/MEK signaling cascades determine the temporal pattern of ERK1/2 phosphorylation and may thereby guide the phenotypic modulation of vascular smooth muscle cells.
Some Special Devices used in the New Type of Power Plants for the Italian Telecommunication Systems (1979)

The paper describes some devices specially developed for the new type of centralized power plants for telecommunication equipment used by SIP, Italian Telephone Company. The remote rectifier's output power limitation device is of great usefulness in the power rating of the primary power plant, in particular of emergency generating sets. The selective supervising devices are an integral part of the power plants policy that requires, for reliability reasons, parallel operating stand-by units.
A Low-Cost Projector Mosaic with Fast Registration (2002)

We describe a calibration and rendering technique for a projector array that can render a seamless rectangular image on a planar surface. The projectors utilize an attached camera to automatically compute the relative pose among them. We describe calibration of the full system using planar display surface to achieve registration and intensity blending of overlapping images. We present an efficient rendering method to pre-warp images so that they appear correctly on the screen, and show experimental results. 1.
Design and analysis of an information exchange-based radar/communications spectrum sharing system (RCS3) (2016)

The recent explosion in demand for mobile broadband wireless communications (comms) services has created a shortage of Radio Frequency (RF) spectrum below 6 GHz. The demand for additional spectrum places pressure upon governments to release wide swaths of RF spectrum that are exclusively reserved for radar systems. This paper introduces a new spectrum sharing system architecture and set of coexistence mechanisms that mitigate RF interference effects based on the exchange of internal state information between radar and comms systems. The exchange of state information enables radar and comms networks to apply a variety of coordinated coexistence mechanisms that shrinks the minimum required standoff range between systems while sustaining the performance of each system. Our analysis and high fidelity simulations show that a careful selection of coexistence mechanisms reduces the minimum required standoff range up to 8 times compared to the standoff range when no coexistence mechanisms are used.
Thin Film Deposition Using a Dielectric‐barrier Discharge (1991)

The results of thin film deposition using a dielectric‐barrier discharge is reported. A plasma produced by a dielectric‐barrier discharge at near atmospheric pressures is used to deposit thin films of amorphous on stainless steel and graphite substrates. The electrical characteristics of the dielectric‐barrier discharge and emission spectroscopy of the plasma for a discharge are reported. Also, the Auger electron spectroscopy and optical microscopic data on the thin films are presented. The novel discharge reported has the potential for high rates of deposition of thin films at or near atmospheric pressures.
HLA‐F is a surface marker on activated lymphocytes (2010)

Of the three nonclassical class I antigens expressed in humans, HLA-F has been least characterized with regard to expression or function. In this study, we examined HLA-F expression focusing on lymphoid cells, where our previous work with homologous cell lines had demonstrated surface HLA-F expression. HLA-F protein expression was observed by Western blot analysis in all resting lymphocytes, including B cells, T cells, NK cells, and monocytes, all of which lacked surface expression in the resting state. Upon activation, using a variety of methods to activate different lymphocyte subpopulations, all cell types that expressed HLA-F intracellularly showed an induction of surface HLA-F protein. An examination of peripheral blood from individuals genetically deficient for TAP and tapasin expression demonstrated the same activation expression profiles for HLA-F,but with altered kinetics post-activation. Further analysis of CD41+CD25+1 Treg showed that HLA-F was not upregulated on the major fraction of these cells when they were activated,whereas CD41+CD25- T cells showed strong expression of surface HLA-F when activated under identical conditions. These findings are discussed with regard to possible functions for HLA-F and its potential clinical use as a marker of an activated immune response.
A Shape Modeling System with a Volume Scanning Display and Multisensory Input Device (1993)

This paper describes a newly developed 3-D shape modeling system, in which a user can design a free-form surface as if he or she actually manipulates a flexible object made from rubber or clay. Such reality can be realized in the system without any encumbering devices like goggles, glasses, or gloves, which is impossible in conventional virtual reality systems. The system is composed of a volume scanning display for presenting a surface image in a real 3-D space, a multisensory input device for detecting the force for deformation, and a half-silvered mirror for spatial superposition of the image onto the input device. A user can directly manipulate a free-form surface by virtually pushing the image, actually pushing the input device, and at the same time, he or she can feel the input device resist its actual deformation as the resisting force of the virtual surface. The system has several types of deforming models, and two types of free-form surfaces that have different curvatures have been experimentally created.
NEWLY DEVELOPED AUTOFLUORESCENCE IMAGING VIDEOSCOPE SYSTEM FOR THE DETECTION OF COLONIC NEOPLASMS (2005)

Background: Previously, we reported that most gastrointestinal tumors could be distinguished with the Light‐Induced Fluorescence Endoscopy for GastroIntestine system (LIFE‐GI system) using a fiberscope. However, the quality of the fiberscopic images was inferior compared with videoscopic images. Therefore, we developed a new Auto‐Fluorescence Imaging (AFI) videoscope system (manufactured by Olympus Corp.). Methods: We evaluated the clinical usefulness of the AFI videoscope system for the detection of colonic neoplasms. Using this system, we observed 168 colonic polyps. Results: Images obtained by AFI provided better brightness than autofluorescence fiberscopic images and lesion margins were clearly evident. It demonstrated excellent recognition capability to a small lesion that was difficult to be detected by conventional observation. Sensitivity was 89% and specificity 81%, with specificity higher than that of the autofluorescence fiberscopic images. Conclusions: This newly developed AFI videoscope system will be useful for the detection of colonic neoplasms.
MIEC (mixed-ionic-electronic-conduction)-based access devices for non-volatile crossbar memory arrays (2014)

Several attractive applications call for the organization of memristive devices (or other resistive non-volatile memory (NVM)) into large, densely-packed crossbar arrays. While resistive-NVM devices frequently possess some degree of inherent nonlinearity (typically 3–30× contrast), the operation of large ( 1000×1000 device) arrays at low power tends to require quite large ( 1e7) ON-to-OFF ratios (between the currents passed at high and at low voltages). One path to such large nonlinearities is the inclusion of a distinct access device (AD) together with each of the state-bearing resistive-NVM elements. While such an AD need not store data, its list of requirements is almost as challenging as the specifications demanded of the memory device. Several candidate ADs have been proposed, but obtaining high performance without requiring single-crystal silicon and/or the high processing temperatures of the front-end-of-the-line—which would eliminate any opportunity for 3D stacking—has been difficult.
Towards an Economy-Based Optimisation of File Access and Replication on a Data Grid (2003)

We are working on a system for the optimised access and replication of data on a Data Grid. Our approach is based on the use of an economic model that includes the actors and the resources in the Grid. Optimisation is obtained via interaction of the actors in the model, whose goals are maximising the profits and minimising the costs of data resource management. In the system, local optimisation results in global optimisation through emergent marketplace behaviour. In this paper we give an overview of our model and present part of the complex economic reasoning required to support this desired marketplace interaction model.
Detection of Nitrate and Sulfate Anions by Normal Raman Spectroscopy and SERS of Cationic-Coated, Silver Substrates (2000)

The use of normal Raman spectroscopy and surface-enhanced Raman spectroscopy (SERS) of cationic-coated, silver substrates to detect nitrate and sulfate ions in aqueous environments is examined. For normal Raman spectroscopy using near-infrared excitation, a linear concentration response was observed with detection limits of 260 and 440 ppm for nitrate and sulfate, respectively. Detection limits in the low parts-per-million concentration range for these anions are achieved by using cationic-coated, silver SERS substrates. Adsorption of the anions on the cationic-coated SERS substrates is described by a Frumkin isotherm.
Study on Time Constants of Random Telegraph Noise in Gate Leakage Current Through Hot-Carrier Stress Test (2010)

Capture and emission time constants obtained from random telegraph noise in gate leakage current ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Ig</i> RTN) are studied by characterizing an intentionally created trap in thin gate oxide (2.6 nm) in metal-oxide-semiconductor field-effect transistors (MOSFETs). The single oxide trap was generated at the drain edge region in virgin nMOSFETs by drain-avalanche hot-carrier stress. By analyzing the location and energy level of the trap extracted from the experimental data, the time constants of high and low current levels in <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Ig</i> RTN were found to be capture and emission times, respectively.
Involvement of non-coding RNAs in chemotherapy resistance of ovarian cancer (2018)

Ovarian cancer (OC) is the most lethal gynecological malignancy, with a low 5-year survival rate. Most patients with ovarian cancer are diagnosed in late-stages. A rising number of non-coding RNAs (ncRNAs) have been found to act as key regulators of gene expression by applying novel high-thought methods, such as next generation sequencing (NGS). Non-coding RNAs not only play important roles in carcinogenesis, but also affect the clinical treatment strategies. One of the biggest challenge in OC treatment was chemoresistance, which causes poor prognosis and high recurrence rate after applying traditional remedies. Of note, it has been proved that ncRNAs were deeply correlated with chemoresistance in several cancers, which made ncRNAs considered to be potential therapeutic targets in ovarian cancer. Among of all ncRNAs, the studies of miRNAs and lncRNAs in ovarian cancer chemoresistance were much clearer. In this study, we reviewed the most relevant researches in this field, and described the relationships between ncRNAs and chemoresistance in ovarian cancer.
Fast internal marker tracking algorithm for onboard MV and kV imaging systems (2008)

Intrafraction organ motion can limit the advantage of highly conformal dose techniques such as intensity modulated radiation therapy (IMRT) due to target position uncertainty. To ensure high accuracy in beam targeting, real-time knowledge of the target location is highly desired throughout the beam delivery process. This knowledge can be gained through imaging of internally implanted radio-opaque markers with fluoroscopic or electronic portal imaging devices (EPID). In the case of MV based images, marker detection can be problematic due to the significantly lower contrast between different materials in comparison to their kV-based counterparts. This work presents a fully automated algorithm capable of detecting implanted metallic markers in both kV and MV images with high consistency. Using prior CT information, the algorithm predefines the volumetric search space without manual region-of-interest (ROI) selection by the user. Depending on the template selected, both spherical and cylindrical markers can be detected. Multiple markers can be simultaneously tracked without indexing confusion. Phantom studies show detection success rates of 100% for both kV and MV image data. In addition, application of the algorithm to real patient image data results in successful detection of all implanted markers for MV images. Near real-time operational speeds of approximately 10 frames/sec for the detection of five markers in a 1024 x 768 image are accomplished using an ordinary PC workstation.
A Preclinical Murine Model of Hepatic Metastases (2014)

Numerous murine models have been developed to study human cancers and advance the understanding of cancer treatment and development. Here, a preclinical, murine pancreatic tumor model of hepatic metastases via a hemispleen injection of syngeneic murine pancreatic tumor cells is described. This model mimics many of the clinical conditions in patients with metastatic disease to the liver. Mice consistently develop metastases in the liver allowing for investigation of the metastatic process, experimental therapy testing, and tumor immunology research.
Acidity Measurements with the Hydrogen Electrode in Mixtures of Acetic Acid and Acetic Anhydride (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcidity Measurements with the Hydrogen Electrode in Mixtures of Acetic Acid and Acetic AnhydrideJ. Russell and A. E. CameronCite this: J. Am. Chem. Soc. 1938, 60, 6, 1345–1348Publication Date (Print):June 1, 1938Publication History Published online1 May 2002Published inissue 1 June 1938https://pubs.acs.org/doi/10.1021/ja01273a020https://doi.org/10.1021/ja01273a020research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Applications of Solid-Phase Synthesis to Drug Discovery (1997)

This review aims to highlight the opportunities for the utilisation of solid-phase synthesis in the process of drug discovery. The two main sections discuss the preparation and biological testing of compound libraries and the preparation of compound arrays based around approved drugs. Biologically active compounds in assays for enzyme inhibition, membrane­ bound protein ligands and intracellular hormone receptors are discussed, illustrating the power of this relatively new tool in the arena of medicinal chemistry.
Gelatin Facial Skin Simulator for Cutaneous Reconstruction (2015)

Reconstruction of facial defects can be an intimidating endeavor, especially to resident physicians. When local flap reconstruction is preferred, design of the optimal flap can be a difficult choice. Poor selection can lead to unsightly scarring as well as increased morbidity. A low-cost, easy-to-fabricate gelatin prosthetic facial skin simulator is presented to offer training experience in wound closure, local tissue rearrangement, and facial defect reconstruction for resident instruction. In conjunction with a didactic lecture, 10 participants were asked to perform a Z-plasty, bilobed, rhomboid, and paramedian forehead flap, followed by an 18-question survey. While initial impressions are favorable, further validation studies are warranted.
Statistical Consistency of Ranking: Bipartite and Multipartite Cases (2012)

Ranking methods have important applications in many fields such as information retrieval, web search, and collaborative filtering.Understanding statistical properties of ranking is important.This thesis investigates the theoretical relation between loss criteria and the optimal ranking functions driven by the criteria in ranking.In bipartite ranking, the relation between Area Under the Curve (AUC) maximization and minimization of ranking risk under a convex loss is examined.We show
Tricone bit health monitoring using wavelet packet decomposed vibration signal (2018)

This paper presents part of a research work developing an automated bit failure prediction system for drilling applications. The approach relies on analysis of vibration signals generated as a result of bit-ground interactions. Extensive full-scale in-situ tests have been accomplished in participating Canadian mine sites. A high-frequency data acquisition unit was installed in the control cabin of a blasthole drill unit to collect the vibration signal from several accelerometers placed on different spots of the rig. The vibration signals collected from the drill mast were analyzed in time and frequency domains and the frequency pattern produced by worn bit is achieved. The frequency ranges of vibration signal those are affected by bit wear are investigated. An Artificial Intelligence (AI) classifier is being designed to perform the automated bit condition classification based on selected signal features. For this purpose, a time-frequency representation of the vibration signal is achieved by application of Wavelet Packet Decomposition (WPD). This research final outcomes will enable mining operations to improve drilling performance by detection of bit wear status and prediction of the bit catastrophic failure to avoid additional costs and delays for the production.