gebhart/patrepeval huggingface dataset:
Guided tissue regeneration in degree II furcation‐involved mandibular molars (1988)

The present clinical trial was designed to evaluate the regenerative potential of the periodontal tissues in degree II furcation defects at mandibular molars using a surgical treatment technique based on the principles of guided tissue regeneration. The patient sample included 21 subjects, 22-65 years of age. The patients selected had periodontal lesions in the right and left molar regions including advanced periodontal tissue destruction within the interradicular area. After an initial examination, each patient received a series of full-mouth scalings and root planings. 2-3 months later, they were recalled for a baseline examination including assessment of plaque, gingivitis, probing depths and probing attachment levels. The furcation involved molars were randomly assigned in each patient to either a test or a control treatment procedure. The test procedure included the elevation of mucoperiosteal flaps at the buccal and lingual aspect of the alveolar process. The inner surface of each flap was carefully curetted to remove epithelium and granulation tissue. The root surfaces were scaled and planed. A teflon membrane was adjusted to cover the entrance of the furcation area and the adjacent root surfaces as well as a portion of the alveolar bone apical to the crest. The flaps were repositioned and placed on the outer surface of the membrane and secured with interdental sutures which were removed after 10 days of healing. Following surgery, the patients were instructed to rinse the mouth twice daily with chlorhexidine gluconate. A second surgical procedure was performed after a healing period of 1-2 months to remove the teflon membrane.(ABSTRACT TRUNCATED AT 250 WORDS)
Adaptive memory management scheme for MMU-less embedded systems (2016)

This paper presents a memory allocation scheme that provides efficient dynamic memory allocation and defragmentation for embedded systems lacking a Memory Management Unit (MMU). Using as main criteria the efficiency in handling both external and internal memory fragmentation, as well as the requirements of soft real-time applications in constraint-embedded systems, the proposed solution of memory management delivers a more precise memory allocation process. The proposed Adaptive Memory Management Scheme (AMM) maintains a balance between performance and efficiency, with the objective to increase the amount of usable memory in MMU-less embedded systems with a bounded and acceptable timing behavior. By maximizing memory utilization, embedded systems applications can optimize their performance in time-critical tasks and meet the demands of Internet-of-Things (IoT) solutions, without undergoing memory leaks and unexpected failures. Its use requires no hardware MMU, and requires few or no manual changes to application software. The proposed scheme is evaluated providing encouraging results regarding performance and reliability compared to the default memory allocator. Allocation of fixed and random size blocks delivers a speedup ranging from 2x to 5x over the standard GLIBC allocator, while the de-allocation process is only 20% percent slower, but provides a perfect (0%) defragmented memory.
Correlation of permittivity and water content during cerebral edema (1999)

Correlation between the permittivity of white matter and cerebral edema was studied. A time domain reflectometer was used to measure the permittivity changes of canine cerebral white matter due to edema produced in vitro by osmosis over a frequency range of 100 MHz to 1 GHz. For all frequencies, a strong correlation was found between the water content and the dielectric constant (R approximately 0.86) and loss factor (R approximately 0.82). The results suggest that it may be possible to estimate both the tissue water content as well as the composition of the accumulated edematous fluid.
Ionic Liquids in the Preparation of Biopolymer Composite Materials (2009)

Preliminary data are shown for the mechanical properties of cellulose and silk composite blends with and without nanomodifiers. Composite strength increases with increasing cellulose concentration for samples created with two different coagulation solutions. In general, samples containing > 30% silk are difficult to handle and test because they are extremely brittle. The addition of nanocomposites may increase overall strength of samples, but is dependent on the morphology of the nanomaterial added.
ChemInform Abstract: A Novel Precursor for Synthesis of Pure Boron Nitride Nanotubes. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A NOVEL ELECTRONIC BEAM STEERING TECHNIQUE IN TIME MODULATED ANTENNA ARRAY (2009)

In this paper, a novel technique for electronic beam steering in time modulated linear array (TMLA) is proposed. The beam steering technique is realized at the first sideband by controlling the switch-on time sequences of each element in the TMLA without using phase shifters. The differential evolution (DE) algorithm is employed to improve the gain and suppress the sidelobe levels (SLLs) at both the center frequency and the first sideband, simultaneously. An S-band 8-element double-layered printed dipole linear array was used to verify the technique experimentally. Measured results are compared with numerical data, and good agreement is reported. Moreover, some simulation results on the binary phase shift keying (BPSK) modulated signals arriving from different directions received by the proposed approach are presented, which validates the application of the proposed beam steering technique.
A Comprehensive, Model-Based Review of Vaccine and Repeat Infection Trials for Filariasis (2013)

SUMMARY Filarial worms cause highly morbid diseases such as elephantiasis and river blindness. Since the 1940s, researchers have conducted vaccine trials in 27 different animal models of filariasis. Although no vaccine trial in a permissive model of filariasis has provided sterilizing immunity, great strides have been made toward developing vaccines that could block transmission, decrease pathological sequelae, or decrease susceptibility to infection. In this review, we have organized, to the best of our ability, all published filaria vaccine trials and reviewed them in the context of the animal models used. Additionally, we provide information on the life cycle, disease phenotype, concomitant immunity, and natural immunity during primary and secondary infections for 24 different filaria models.
Speculative processing mechanisms in a parallel Lisp machine: BIDDLE (2002)

In a system supporting parallel execution, speculative processing can be used to increase the amount of parallelism. The authors propose a speculative execution scheme for the data-driven Lisp machine BIDDLE. Execution priorities are assigned to instructions according to their nested position in conditional statements. These priorities are updated dynamically during execution as results of Boolean guards of conditional execution are returned. The authors describe the ways to maintain the environment and handle side effects and tuplespace in the speculative context. Each speculative branch is given a separate environment. Any side-effects made are merged into the environment of the calling instruction when the speculation is confirmed, and removed if they are unwanted. It is also demonstrated that infinite data structures can be supported by this scheme.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Influence of Cutter Geometry In Rock Cutting (2001)

Since the early nineties a lot of researches have been realized in rock cutting with PDC cutters. In 1992 Detournay and Defourny developed a phenomenological model (DD model) based on the suggestion proposed by Fairhurst and Lacabanne (1957): ''The cutter / rock interaction is characterized by two processes: rock cutting and frictional contact''. Based on the DD model, a testing device has been developed at the University of Minnesota, Minneapolis: the Rock Strength Device (RSD). The RSD is designed to scratch rock samples with a constant depth of cut using a single cutter. It has been developed not only to measure strength parameters of rock specimens, but also to understand the mechanisms involved in rock cutting. Several research aspects have been studied on the RSD to valid the DD model. Lasserre (1994), Adachi (1996), Nicodème (1997), Richard (1998), Lhomme (1999) have studied different particular topics such as the correlation between specific energy and rock properties, failure mode in rock cutting, friction phenomena. Richard (1999) suggested the existence of a 3D effect influencing the specific energy. No real research approach has been conducted to understand the so-called 3D effect. This was the objective of this research.
Nearest Neighbor Value Interpolation (2012)

This paper presents the nearest neighbor value (NNV) algorithm for high resolution (H.R.) image interpolation. The difference between the proposed algorithm and conventional nearest neighbor algorithm is that the concept applied, to estimate the missing pixel value, is guided by the nearest value rather than the distance. In other words, the proposed concept selects one pixel, among four directly surrounding the empty location, whose value is almost equal to the value generated by the conventional bilinear interpolation algorithm. The proposed method demonstrated higher performances in terms of H.R. when compared to the conventional interpolation algorithms mentioned.
Angiopoietin-Like 3 Deficient Bone Marrow Has Decreased Ability to Support Hematopoietic Stem Cells (2008)

Abstract We previously identified a group of angiopoietin-like proteins (Angptls) as new growth factors that stimulate ex vivo expansion of hematopoietic stem cells (HSCs). To investigate the physiological function of Angptl3 in bone marrow, we characterized the Angptl3 deficient mice, and identified several defects in the hematopoietic compartment. When we transplanted wild-type HSCs into lethally irradiated Angptl3 deficient mice, we found that the mutant bone marrow stroma have much lower ability to support in vivo expansion of HSCs. We sought to identify the Angptl3-producing cells in mouse bone marrow stroma, and showed that Angptl3 is highly expressed in CD45-SSEA4+ cells, which are mesenchymal stem cells (MSCs). Indeed, the co-culture of HSCs with CD45-SSEA4+ MSCs resulted in ex vivo expansion of HSCs. DNA microarray analysis, real-time RT-PCR, and flow cytometry were used to identify the intracellular factors that are responsible for Angptl3’s effects on HSCs. This investigation demonstrated that Angptl3-stimulated HSC expansion is contributed by its activities to support HSC self-renewal and inhibit hematopoietic differentiation. Our study will likely lead to the identification of a novel component of the niche for HSCs.
Fabrication and Biomedical Applications of “Polymer-Like” Nucleic Acids Enzymatically Produced by Rolling Circle Amplification (2019)

Rolling circle amplification (RCA) is an isothermal enzymatic amplification reaction, which is used to massively produce periodic long-single-stranded DNA/RNA with predesigned sequences and functions. The RCA technique not only shows unparalleled advantages in constructing functional DNA assemblies; and the RCA products can also serve as high-performance scaffolds to interact with or accommodate foreign moieties, i.e., therapeutic nucleic acids, proteins, lipids, cationic polymers, and metal nanoparticles (NPs), etc. to fabricate multifunctional and bioresponsive materials with various sizes and morphologies. The RCA product is also a kind of high-molecular-weight polyanion with strong inter/intra-molecular interactions, which provides great opportunities for regulating the condensation states of DNA nanomedicines and bulk materials. Based on all these good properties, the RCA-based materials have shown more and more practical potentials in biomedical fields. In this review, we summarize the recent development of RCA-based origami structures, NPs, hydrogels, and metallization, for which the fabrication methods, their biomedical applications, and future prospects are carefully discussed.
Structural changes during the decomposition of calcium hydroxide. Report for October 1988-July 1989 (1989)

The paper discusses the production of calcium hydroxides with surface areas of 6-74 sq m/g, in an attempt to develop more reactive sorbents for SO{sub 2} capture during furnace injection. It was found that adding alcohol to the water of hydration yielded hydroxides with surface areas up to 40 sq m/g. The sorbents were produced using double hydration and a mixture of water and methyl alcohol. When these sorbents were injected into the boiler, however, only marginal increases in SO2 capture were observed. The purpose of the research was to monitor structural changes in these sorbents during calcination in order to determine the reason for their relatively poor performance. For a given calcine and fixed conditions of calcination, the surface area decreased and median pore size increased with decreasing particle size in the 1.2-7.5 micrometer size range. This suggests that sintering advances more quickly in fine particles. For sorbents described here and using one precursor limestone, a correlation could be found between structural properties of Ca(OH)2 and nascent CaO. Increased surface area of Ca(OH)2 led to higher surface area of CaO after calcination at fixed conditions. The theoretical existence of an optimum combination of surface area and porosity of CaOmore » was verified.« less
Cloning, nucleotide sequence, and overexpression of the gene coding for delta 5-3-ketosteroid isomerase from Pseudomonas putida biotype B (1994)

The structural gene coding for the delta 5-3-ketosteroid isomerase (KSI) of Pseudomonas putida biotype B has been cloned, and its entire nucleotide sequence has been determined by a dideoxynucleotide chain termination method. A 2.1-kb DNA fragment containing the ksi gene was cloned from a P. putida biotype B genomic library in lambda gt11. The open reading frame of ksi encodes 393 nucleotides, and the amino acid sequence deduced from the nucleotide sequence agrees with the directly determined amino acid sequence (K. Linden and W. F. Benisek, J. Biol. Chem. 261:6454-6460, 1986). A putative purine-rich ribosome binding site was found 8 bp upstream of the ATG start codon. Escherichia coli BL21(DE3) transformed with the pKK-KSI plasmid containing the ksi gene expressed a high level of isomerase activity when induced by isopropyl-beta-D-thiogalactopyranoside. KSI was purified to homogeneity by a simple and rapid procedure utilizing fractional precipitation and an affinity column of deoxycholate-ethylenediamine-agarose as a major chromatographic step. The molecular weight of KSI was 14,535 (calculated, 14,536) as determined by electrospray mass spectrometry. The purified KSI showed a specific activity (39,807 mumol min-1 mg-1) and a Km (60 microM) which are close to those of KSI originally obtained from P. putida biotype B.
Digitogenin (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDigitogeninDonald L. Klass, Mary Fieser, and Louis F. FieserCite this: J. Am. Chem. Soc. 1955, 77, 14, 3829–3833Publication Date (Print):July 1, 1955Publication History Published online1 May 2002Published inissue 1 July 1955https://pubs.acs.org/doi/10.1021/ja01619a045https://doi.org/10.1021/ja01619a045research-articleACS PublicationsRequest reuse permissionsArticle Views122Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of environment on formation of finished surface in drilling aluminum and aluminum alloys (1972)

This paper reports influences of environment on hole surface formation of aluminum and aluminum alloys drilling. Oxygen, carbon dioxide, nitrogen and compressed air were used to jet-blow through a lead hole toward a direction opposite to the feeding direction of a drill. The results obtained are as follows:Surfaces of 5056-H and 6061-T8 alloys were smooth when oxygen and carbon dioxide were used, while they were rough when compressed air and nitrogen were used. Active action of these gases presumably affected adhesion during friction between a drill and hole surfaces. Effects of gases on surfaces roughness of drill holes were smaller in 2017-T3 and 2024-T3 alloys than in 5056-H and 6061-T8 alloys. Environmental effects were hardlly seen in aluminum, 1100-F. Shapes of chips were sensitive to environment and indicated a process of finish surface formation.
Performance and Cramer–Rao Bounds for DoA/RSS Estimation and Transmitter Localization Using Sectorized Antennas (2015)

Using collaborative sensors or other observing devices equipped with sectorized antennas provides a practical and low-cost solution to direction-of-arrival (DoA) and received signal strength (RSS) estimation, as well as noncooperative transmitter (TX) localization. In this paper, we study the performance and theoretical bounds of DoA/RSS estimation and localization using sectorized antennas. We first show that the sector-power measurements at an individual sensor form a sufficient statistic for DoA/RSS estimation and TX localization. Motivated by that, we then derive the Cramer-Rao bound (CRB) on DoA/RSS estimation based on sector-powers and study its asymptotic behavior. Moreover, we derive an analytical expression for the mean square error (MSE) of a practical sectorized-antenna-based DoA estimator, compare its performance to the derived CRB, and study its asymptotic properties. Next, we derive the CRB for localization based on sector-powers. The resulting CRB is a lower bound for a localization system where the DoA/RSS estimates, obtained from sector-powers at individual sensors, are fused together into a location estimate. Moreover, the CRB also covers the more general case of a localization system where the sector-powers from individual nodes are directly fused together, without an intermediate DoA/RSS estimation step. We compare the obtained CRB to a localization approach employing an intermediate DoA/RSS estimation step and observe that skipping this intermediate processing step may result in a substantially improved localization performance. Finally, we study the influence of various important system parameters, such as the number of sensors, sectors, and measurement samples, on the achievable estimation and localization performance. Overall, this paper demonstrates and quantifies the achievable DoA/RSS estimation and localization performance of sectorized antennas and provides comprehensive design guidelines for sector-power based low-complexity localization systems.
Methylation suppresses the proteasome‐inhibitory function of green tea polyphenols (2007)

Under physiological conditions, biotransformation reactions, such as methylation, can modify green tea polyphenols (GTPs) and therefore limit their in vivo cancer-preventive activity. Although a recent study suggested that methylated polyphenols are less cancer-protective, the molecular basis is unknown. We previously reported that ester bond-containing GTPs, for example (-)-epigallocatechin-3-gallate [(-)-EGCG] or (-)-epicatechin-3-gallate [(-)-ECG], potently and specifically inhibit the proteasomal chymotrypsin-like activity. In this study, we hypothesize that methylated GTPs have decreased proteasome-inhibitory abilities. To test this hypothesis, methylated (-)-EGCG and (-)-ECG analogs that can be found in vivo were synthesized and studied for their structure-activity relationships (SARs) using a purified 20S proteasome. The addition of a single methyl group on (-)-EGCG or (-)-ECG led to decreased proteasome inhibition and, as the number of methyl groups increased, the inhibitory potencies further decreased. These SARs were supported by our findings from in silico docking analysis published recently. Previously, we synthesized a peracetate-protected (-)-EGCG molecule, Pro-EGCG (1), to enhance its cellular permeability and stability, and current HPLC analysis confirms conversion of Pro-EGCG (1) to (-)-EGCG in cultured human leukemic Jurkat T cells. Furthermore, in this study, peracetate-protected forms of methylated GTPs were added in intact Jurkat T cells to observe the intracellular effects of methylation. Peracetate-protected, monomethylated (-)-EGCG induced greater cellular proteasome inhibition and apoptosis than did peracetate-protected, trimethylated (-)-EGCG, consistent with the potencies of the parent methylated analogs against a purified 20S proteasome. Therefore, methylation on GTPs, under physiological conditions, could decrease their proteasome-inhibitory activity, contributing to decreased cancer-preventive effects of tea consumption.
Application architectures for smart multi-device applications (2012)

The growing number of connected devices and increasing availability of solutions based on the concept of the Internet of Things make our environment increasingly smart and capable. However, existing application development processes and tools, designed for single device applications, do not allow developers to fully address this opportunity. It is very difficult to create applications that employ multiple devices and use the context information provided by ubiquitous sensors. In this paper, we present the concept of Device Independent Architecture, which can be used to separate applications from devices and which provides a uniform way of building smart multi-device applications.
Confirmation of hepatitis C infection: a comparison of five immunoblot assays (1994)

Detection of HCV antibodies was not refined by the addition of new HCV antigens (NS5, E2/NS1), but by improved classical antigens (core, NS3, NS4). Replacement of the commonly used RIBA-2 will resolve the status of a high proportion of RIBA-2-indeterminate samples.
Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate (2018)

The interplay between the accumulation of cationic MnPs and their potency as catalysts for oxidation of Asc, protein cysteines, and GSH controls the magnitude of their anticancer therapeutic effects.