gebhart/patrepeval huggingface dataset:
Phase I trial of ARRY-520 in relapsed/refractory multiple myeloma (RR MM). (2010)

8132 Background: Kinesin Spindle Protein (KSP) is required for cell cycle progression through mitosis. ARRY-520 is a potent, selective inhibitor of KSP, arresting cells in mitosis with subsequent onset of apoptosis. Malignancies, such as MM, depending on the survival protein MCL-1 rapidly undergo apoptosis following treatment with ARRY-520. ARRY-520 shows potent activity in preclinical MM models, providing a strong rationale for its clinical investigation in this disease Methods: This phase I study was designed to evaluate the safety, pharmacokinetics and pharmacodynamics of ARRY-520 administered intravenous (IV) on D1 and D2 q 14 days without/with granulocyte colony stimulating factor (G-CSF). Patients (pts) with RR MM or plasma cell leukemia with ≥ 2 prior lines of therapy (including a bortezomib and IMiD-based regimen, unless refusing or ineligible for this therapy) were eligible. Cohorts of at least 3 pts are being enrolled in a classical 3+3 dose escalation design. Pts are treated for 2 cycles for safety evaluation prior to dose escalation. Results: 13 pts have been treated to date, with a median age of 55 years (range 44-78) and a median of 4 prior regimens (range 3-13). All pts received prior bortezomib, 9 pts prior lenalidomide, 5 pts prior thalidomide, and 10 pts had an autologous stem cell transplant. Pts received ARRY- 520 without G-CSF at 1 mg/m2/day (n = 3), and at 1.25 mg/m2/day (n = 7). Dose-limiting toxicity (DLT) of Grade 4 neutropenia was observed at 1.25 mg/m2/day, and this was considered the maximum tolerated dose without G-CSF. As neutropenia was the DLT, dose escalation with G-CSF support was initiated, and 3 pts have been treated to date at 1.5 mg/m2/day with G-CSF. The most commonly reported (> 1 pt) treatment-related adverse events include anemia, neutropenia and thrombocytopenia as well as fatigue and nausea. No mucositis or peripheral neuropathy were noted. The median number of cycles is 4 (range 1-15+). One pt experienced a partial response (ongoing in Cycle 15 at 1 mg/m2/day, 8 prior regimens, decrease of % plasma cells in the bone marrow from 30 to 0%). Conclusions: ARRY-520 shows promising signs of clinical activity and has been well tolerated in pts with MM. Enrollment is ongoing at 1.5 mg/m2/day with G-CSF support. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Array BioPharma Amgen, Array BioPharma, Bristol-Myers Squibb, Celgene, Facet Biotech, Genzyme, Johnson & Johnson, Millennium, Novartis Array BioPharma Celgene, Millennium Bristol-Myers Squibb, Celgene, Cepahlon, Facet Biotech, Gloucester Pharmaceuticals, Merck, Millennium, Novartis
Development of Self-Cleaning Solar Collectors for Minimizing Energy Yield Loss Caused by Dust Deposition (2013)

Concentrated Solar Power (CSP) systems used for photothermal conversion of solar energy to electricity are capable of meeting a large fraction of the global energy requirements. CSP plants are inherently robust with respect to the availability of materials, technology, and energy storage. However, dust depositions on solar collectors cause energy yield loss annually, ranging from 10 to 50% depending upon their location in the semi-arid and desert lands. Mitigation of energy loss requires manual cleaning of solar mirrors with water. A brief review of the soiling related losses in energy yield of the CSP plants is presented, which shows that cleaning of the CSP mirrors and receivers using water and detergent is an expensive and time-consuming process at best and is often impractical for large-scale installations where water is scarce. We report here our research effort in developing an electrodynamic dust removal technology that can be used for keeping the solar collectors clean continuously without requiring water and manual labor. Transparent electrodynamic screens (EDS), consisting of rows of transparent parallel electrodes embedded within a transparent dielectric film can be integrated on the front surface of the mirrors and on the receivers for dust removal for their application as self-cleaning solar collectors. When the electrodes are activated, over 90% of the deposited dust is removed. A summary of the current state of prototype development and evaluation of EDS integrated solar mirrors and experimental data on the removal of desert dust samples are presented. A brief analysis of cost-to-benefit ratio of EDS implementation for automated dust removal from large-scale solar collectors is included.
Hardware implementation of a nonlinear processor (2003)

Several advanced DSP algorithms, arising in applications such as wireless communications, computer graphics, computerized tomography, and speech compression, require extensive use of nonlinear functions. We discuss a new hardware approach to high-speed computation of nonlinear functions. With this approach all of the functions needed can be regularized into a single efficient algorithm. Further, highly reduced cycle implementations can be achieved. Specifically, for real arguments, a new result can be produced every cycle-in a pipelined mode. The underlying principle which has made the combined goals of high-speed and multi-functionality possible is significance-based polynomial interpolation of very small ROM tables. Considered are the following seven functions: arctangent, cosine, logarithm, reciprocal, reciprocal-square-root, sine, and square-root. Also presented is a theoretical development for error prediction, a tool for the selection of architectural parameters. Finally, the paper presents a novel technique, named here as 'microshaping', for avoiding overflows, thereby eliminating exception handling.
Building a Participatory Culture: Collaborating with Student Organizations for Twenty-first Century Library Instruction (2011)

Today’s students are critical thinkers, collaborators, and creators. They expect to participate in twenty-first century learning environments not as passive information consumers (think lectures), but as active contributors (think team-based problem-solving). There are opportunities for instruction librarians to collaborate directly with student-led organizations. These partnerships have the potential to increase attendance at library events and provide platforms for students to engage in richer forms of exploratory learning that incorporate twenty-first century skills. This article will discuss the literature surrounding library instruction collaborations, identify “Librarian–Student Organization Collaborations” as an important form of partnership, and supply specific case studies of successful library instruction events based on these collaborations.
Failure of therapy with 2,3-dihydroxybenzoic acid to modify the course of sepsis-induced lung injury (1990)

Oxidant-induced injury of the pulmonary microvasculature reportedly contributes to an increase in microvascular permeability and pulmonary hypertension, both of which are principal features of acute lung injury (ALI). We tested the hypothesis that antioxidant therapy with 2,3-dihydroxybenzoic acid (DHB), initiated in awake sheep after the development of sepsis-induced ALI, would ameliorate the progression of these lesions. DHB has many actions that suggested to us the potential for demonstrating benefit in ALI complicating sepsis; it is a nontoxic hydroxyl-radical scavenger that also inhibits the cyclooxygenase pathway and acts as a weak iron chelator. In preliminary experiments, we demonstrated that pretreatment with DHB prevented an increase in mean pulmonary arterial pressure, plasma thromboxane A2, measured as its metabolite thromboxane B2, and lymph total protein clearance that otherwise followed an infusion of zymosan-activated plasma (ZAP) in sheep. In subsequent experiments, 12 additional sheep were rendered septic by cecal ligation and perforation. Twenty-four to 36 h after cecal ligation and perforation, an increase in lung microvascular permeability was confirmed, because pulmonary lymph flow had increased by 82% while the mean lymph-to-plasma total protein ratio was unchanged from baseline. At this point, six sheep were then treated with parenteral DHB and six with DHB vehicle for the subsequent 24 h. In contrast to the demonstrated benefit of DHB pretreatment in preventing ALI secondary to an infusion of ZAP, the progressive increase in lymph total protein clearance that complicated septic lung injury in the DHB vehicle group throughout this 24-h study period was not ameliorated in the DHB treatment group. However, DHB did prevent a modest increase in mean pulmonary arterial pressures that was demonstrated in the DHB vehicle group throughout this 24-h treatment period. Although pretreatment prevented ALI after a ZAP infusion, we conclude that DHB only incompletely modified disease progression when administered after the onset of sepsis-induced ALI because it ameliorated the pulmonary hypertensive response without concurrently modifying an increase in lung microvascular fluid flux.
Steel Cord Skim Compounds: The Achievement and Maintenance of Maximum Adhesion (1972)

Abstract The adhesion of rubber to brassed steel cord has been assessed by a static pull out test which avoids many of the problems associated with current H tests. The test is simple in operation and with a uniform stress distribution gives results which are independent of modulus, with a high degree of reproducibility. The effect of a range of compounding variables on adhesion has been examined. Curing systems and polymer type were identified as having the greatest influence. High unaged adhesion was achieved with a curing system based on 2-(Morpholinothio)benzothiazole in 100 NR or NR/BR blends.Factory processing can reduce adhesion in the final vulcanizate and the addition of N-cyclohexylthiophthalimide will prevent this. Overcure and oxidative aging also reduce adhesion. Systems based on low sulfur levels with 2(Morpholinothio)benzothiazole and N,N-dithiodimorpholine confer high resistance in NR and NR/BR blends. The antidegradant combination of N(l,3-dimethylbutyl)-N'-phenyl- p -phenylenediamine and polymerized 2,2,4-trimethyl-l-2-dihydroquinoline gave further improvements in oxidative aging resistance without reducing unaged adhesion.
Training Convolutional Neural Networks for Translational Invariance on SAR ATR (2016)

In this paper we present a comparison of the robustness of Convolutional Neural Networks (CNN) to other classifiers in the presence of uncertainty of the objects localization in SAR image.We present a framework for simulating simple SAR images, translating the object of interest systematically and testing the classification performance.Our results show that where other classification methods are very sensitive to even small translations, CNN is quite robust to translational variance, making it much more useful in relation to Automatic Target Recognition (ATR) in a real life context.
ChemInform Abstract: Suzuki Coupling Reaction Using Hybrid Pd Nanoparticles (2014)

Abstract Review: 113 refs.
Seamless network-wide IGP migrations (2011)

Network-wide migrations of a running network, such as the replacement of a routing protocol or the modification of its configuration, can improve the performance, scalability, manageability, and security of the entire network. However, such migrations are an important source of concerns for network operators as the reconfiguration campaign can lead to long and service-affecting outages.
Chemical nature of feeding stimulants for the juvenile Dover sole, <i>Solea solea</i> (L.) (1980)

Juvenile Dover sole, Solea solea , were weaned from a live food, Artemia salina nauplii, on to a casein‐based particulate diet flavoured with flesh of the mussel, Mytilus edulis . These fish would not accept an unflavoured casein‐based diet but readily ate the diet flavoured with either mussel flesh or a mixture of pure chemicals whose composition was based on an analysis of the low‐molecular weight fraction of mussel flesh. The rate of growth and survival over a seventy‐seven day period was essentially the same on either of the flavoured diets. The active constituent in the mixture of pure chemicals was identified as glycine betaine for fish of wet weight exceeding 50g while glycine betaine with certain L‐amino‐acids was required for fish of about 2.5 g wet weight. These results are discussed in relation to the known feeding behaviour and food preferences of the wild Dover sole.
Theoretical and experimental studies on the corrosion inhibition potentials of some purines for aluminum in 0.1 M HCl (2014)

Experimental aspect of the corrosion inhibition potential of adenine (AD), guanine (GU) and, hypoxanthine (HYP) was carried out using weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) methods while the theoretical aspect of the work was carried out by calculations of semi-empirical parameters (for AM1, MNDO, CNDO, PM3 and RM1 Hamiltonians), Fukui functions and inhibitor-metal interaction energies. Results obtained from the experimental studies were in good agreement and indicated that adenine (AD), guanine (GU) and hypoxanthine (HYP) are good adsorption inhibitors for the corrosion of aluminum in solutions of HCl. Data obtained from electrochemical experiment revealed that the studied purines functioned by adsorption on the aluminum/HCl interface and inhibited the cathodic half reaction to a greater extent and anodic half reaction to a lesser extent. The adsorption of the purines on the metal surface was found to be exothermic and spontaneous. Deviation of the adsorption characteristics of the studied purines from the Langmuir adsorption model was compensated by the fitness of Flory Huggins and El Awardy et al. adsorption models. Quantum chemical studies revealed that the experimental inhibition efficiencies of the studied purines are functions of some quantum chemical parameters including total energy of the molecules (TE), energy gap (E L-H), electronic energy of the molecule (EE), dipole moment and core-core repulsion energy (CCR). Fukui functions analysis through DFT and MP2 theories indicated slight complications and unphysical results. However, results obtained from calculated Huckel charges, molecular orbital and interaction energies, the adsorption of the inhibitors proceeded through the imine nitrogen (N5) in GU, emanine nitrogen (N7) in AD and the pyridine nitrogen (N5) in HPY.
On MIMO Relay with Finite-Rate Feedback and Imperfect Channel Estimation (2007)

We investigate how finite-rate feedback and imperfect channel estimation impact MIMO relay network throughput and design in this paper. We start from multi-antenna transceiver with random beamforming and formulate the SNR and capacity loss due to channel estimation and quantization errors. We thereafter extend the analysis to multi-antenna relay network with multiple MIMO relay hops and discuss how the end-to-end throughput is scaled by MIMO pilot size, codebook size, relay network size and inter-beam interference. Some tradeoffs for MIMO relay network design are revealed. Computer simulations are provided to demonstrate our results.
Use of dimethoxydiphenylsilane, NN-dimethylformamide, and toluene-p-sulphonic acid as a novel acetalating reagent (1980)

Reaction of sucrose with a combination of dimethoxydiphenylsilane, NN-dimethylformamide, and toluene-p-sulphonic acid gave a mixture of 1′,2-O-(diphenylsilylene)sucrose and 1′,2 : 6,6′-di-O(diphenylsilylene) sucrose, from which the 1′,2-silylene acetal has been isolated directly as its hexa-acetate (1) in 18% yield; the 1′,2 : 6,6′-disilylene acetal tetra-acetate (2) has been isolated after column chromatography.
Bibliography of Books Dealing with Problems of Joint Interest to the Legal and Medical Professions (1946)

with the College of Law and the College of Medicine.The present bibliography is a selected list and does not purport to be exhaustive.'Many older works, many books in the foreign languages, and a few more recent productions have been omitted.
N-polar GaN/InAlN MIS-HEMT with 400-GHz &#x0192;<inf>max</inf> (2012)

This paper reports 400-GHz ƒ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</inf> using a tall-stem T-gate on an N-polar GaN/InAlN MIS-HEMT grown by MOCVD. This is the highest reported ƒ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</inf> value to date for an N-polar GaN HEMT and is among the highest values for all GaN HEMTs.
A Novel Hybrid Transcatheter Ablation System That Combines Radiofrequency and Cryoenergy (2007)

A versatile catheter system was fashioned capable of creating standard cryoablation lesions, standard RF lesions, and simultaneous lesions of similar dimension to irrigated RF.
[Progression and stagnation of caries]. (1989)

When carious lesions are forming, it is possible that they progress rapidly, but slow progress up to complete stagnation also may occur. Which mode of development prevails depends on the demineralization potential in the oral cavity, but also on remineralizing factors. Infrequent sugar pulses and careful plaque removal diminish the cariogenic forces; stagnation of lesion formation and preservation of integrity are favoured by ample salivary secretions, high mineral content of the diet and lifelong frequent availability of small amounts of fluoride.
A Fully Parallel Nonbinary LDPC Decoder With Fine-Grained Dynamic Clock Gating (2014)

Nonbinary LDPC (NB-LDPC) codes, defined over Galois field, offer better coding gain and a lower error floor than binary LDPC codes. However, the complex decoding and large memory requirement have prevented any practical chip implementations. We present a 1.22 Gb/s fully parallel decoder of a GF(64) (160, 80) regular-(2, 4) NB-LDPC code in 65 nm CMOS. The reduced number of edges in NB-LDPC code's factor graph permits a low wiring overhead in the fully parallel architecture. The throughput is further improved by a one-step look-ahead check node design that increases the clock frequency to 700 MHz, and the interleaving of variable node and check node operations that shortens one decoding iteration to 47 clock cycles. We allow each processing node to detect its own convergence and apply dynamic clock gating to save power. When all processing nodes have been clock gated, the decoder terminates and continues with the next input to increase the throughput to 1.22 Gb/s. The dynamic clock gating and decoder termination improve the energy efficiency to 3.03 nJ/b, or 259 pJ/b/iteration, at 1.0 V and 700 MHz. Voltage scaling to 675 mV improves the energy efficiency to 89 pJ/b/iteration for a throughput of 698 Mb/s at 400 MHz.
Optimisation of dispersion compensating fibresforcabled long-haul applications (2000)

Dispersion compensating fibres for dispersion-flattened hybrid transmission lines based on non-dispersion shifted fibres have been experimentally investigated. Average values obtained from the production of thousands of kilometres of fibres with different dispersions and thereby different compensation length ratios are given. Optimisation of hybrid lines for minimisation of span attenuation and fibre nonlinearity is described.
Mechanically Powered Transparent Flexible Charge‐Generating Nanodevices with Piezoelectric ZnO Nanorods (2009)

Transparent flexible charge-generating piezoelectric nanodevices are developed. The resulting integrated nanodevice generates a noticeable current when it is pushed by application of an external load. Piezoelectric ZnO nanorod-based nanodevices with embossed PdAu top electrodes produce the highest output current density of approximately 10 μA cm−2 at a load of 0.9 kgf.
A 2&#x00B5;A temperature compensated mems-based real time clock with &#x00B1;4 ppm timekeeping accuracy (2014)

This paper presents a MEMS-based real time clock with a temperature compensation system. The implemented circuit achieves a timekeeping accuracy of ±4 ppm over -40 °C... 85 °C temperature range. It is built using a 27 kHz silicon resonator, differential PTAT temperature sensor with a 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> order ΣΔADC, and a DSP block for temperature frequency compensation. The circuit is powered by a 1.8V supply and draws 2 μA current. The system has been implemented using a 0.18 μm CMOS process.
Self-assembly of single and closely spaced nucleosome core particles (1980)

Self-assembly of DNA with the four core histones but in the absence of H1 generates nucleosome core particles which are spaced randomly over large distances. Closely spaced core particles, however, exhibit a preferred short linkage which is not a multiple of 10 base pairs. They bind about 140 base pairs whereas apparently shorter DNA lengths per nucleosome observed after digestion with micrococcal nuclease are the result of degradation from the ends. The DNA length of one superhelical turn in the core particle is 83 +/- 4 base pairs. Single core particles may bind more DNA than closely spaced core particles but probably less than two full turns of 168 base pairs. The internal structures of single and of native core particles are very similar as judged by their amount of DNA, sedimentation coefficient, appearance in the electron microscope, and digestion with DNase I. In addition to core particles, a particle is described which sediments at 9 S and consists of 108 base pairs of DNA bound to the histone octamer. It appears to be the smallest stable "core particle" but it is not a degradation product of the 146-base-pair core particle. Digestion of end-labeled 9 S and nucleosome core particles with DNase I shows distinct differences.
Nanostructured Mesoporous NbRu<sub>y</sub>O<sub>z</sub> as a Catalytic Support for Fuel Cells (2009)

An electrically conductive NbRu (8:1 by weight) support with high surface area of ~170m2/g has been synthesized by using the spray pyrolysis technique. The support is a highly stable phase equivalent to conductive Nb(IV), thanks to intrinsic alteration of the niobia by the ruthenium in an inter-metallic phase. Platinum deposited by various methods onto the NbRuyOz support is initially electrochemically deactivated until its surface can be re-activated under argon at a scanning rate of 250 mV/s.
Digital versus conventional templating techniques in preoperative planning for total hip arthroplasty. (2009)

Digital preoperative templating is as reliable as conventional templating techniques.
Microcalorimetric measurements of heat production in isolated rat brown adipocytes. (1992)

Heat production, oxygen consumption, and lipolysis in isolated interscapular brown adipocytes from the rat were investigated. Epinephrine, norepinephrine, and isoproterenol increased heat production in a concentration-dependent manner, showing, about 6-, 4-, and 5-fold higher effects than controls, respectively. The concentration of isoproterenol for threshold heat production and glycerol release were 10(-10) M and 10(-9) M, respectively. The fact that 10(-9) M isoproterenol increased heat production by about 3-fold while glycerol release had no effect at all indicates that calorimetry is more appropriate for investigation of brown adipocytes. At least the method is more sensitive than that of measuring glycerol release.