gebhart/patrepeval huggingface dataset:
In Vitro Characterization of Circulating Endothelial Progenitor Cells Isolated from Patients with Acute Coronary Syndrome (2013)

Our data indicate that a careful characterization of true EPC is needed in order to design future studies in the clinical autologous setting of patients with ACS.
Alternatives to map-based pedestrian navigation with location-aware mobile devices (2009)

Tm opinnytety ksittelee eri tapoja, kuinka jalankulkijoille voidaan vlitt navigoimisen apuna kytettv informaatiota
Glutamate Decreases Mitochondrial Size and Movement in Primary Forebrain Neurons (2003)

Mitochondria are essential to maintain neuronal viability. In addition to the generation of ATP and maintenance of calcium homeostasis, the effective delivery of mitochondria to the appropriate location within neurons is also likely to influence their function. In this study we examined mitochondrial movement and morphology in primary cultures of rat forebrain using a mitochondrially targeted enhanced yellow fluorescent protein (mt-eYFP). Mt-eYFP-labeled mitochondria display a characteristic elongated phenotype and also move extensively. Application of glutamate to cultures results in a rapid diminution of movement and also an alteration from elongated to rounded morphology. This effect required the entry of calcium and was mediated by activation of the NMDA subtype of glutamate receptor. Treatment of cultures with an uncoupler or blocking ATP synthesis with oligomycin also stopped movement but did not alter morphology. Interestingly, application of glutamate together with the uncoupler did not prevent the changes in movement or shape but facilitated recovery after washout of the stimuli. This suggests that the critical target for calcium in this paradigm is cytosolic. These studies demonstrate that in addition to altering the bioenergetic properties of mitochondria, neurotoxins can also alter mitochondrial movement and morphology. We speculate that neurotoxin-mediated impairment of mitochondrial delivery may contribute to the injurious effects of neurotoxins.
Immunolocalization of polycystin in human tissues and cultured cells. (1996)

The gene PKD I, which is mutated in type I autosomal dominant polycystic kidney disease (ADPKD 1), encodes a large protein of novel structure and unknown function and distribution that has been named polycystin. To gain better insight into polycystin function, we raised a panel of antisera against synthetic peptide antigens derived from the unique portion of the predicted polycystin sequence. Antisera were used to immunolocalize the protein in a variety of normal human fetal, childhood, and adult tissues as well as kidney and liver tissue from individuals with ADPKD 1, the genetically distinct ADPKD 2, and acquired renal cystic disease (ARCD). Subcellular localization studies were carried out on human cultured cell lines of renal epithelial origin. In normal tissues, polycystin expression was noted in renal tubular epithelial cells from 20 weeks gestation to 4 years postpartum, and in hepatocytes and biliary epithelium up to 4 years, but not in adult kidney or liver. Expression also was present in fetal and childhood pancreas, myocardium, bowel, and adrenal medulla. In cell lines of renal epithelial origin, immunofluorescence and immunoelectron-microscopical studies showed localization of polycystin epitopes to the peripheral cytoplasm. Kidney and liver from four unrelated adults with known ADPKD 1 showed strong staining, which was not seen in kidney and liver from one adult with ADPKD 2 or in kidney from three patients with ARCD. We conclude that polycystin is expressed in renal tubular epithelial cells as well as a variety of other cell types during development and growth but is absent or weakly expressed in adult kidney and liver. Overexpression of polycystin epitopes within affected tissue may be a specific feature of some or all cases of ADPKD 1.
Highly Reliable 256Mb NOR Flash MLC with Self-Aligned Process and Controlled Edge Profile (2005)

We present a comparative investigation of two self-aligned processes, viz. Self-Aligned Poly (SAP) and Self-Aligned STI (SA-STI) for high-density flash memory cells. SAP is shown to lead to narrow erase Vth dispersion and better endurance reliability via the control of oxide edge profile. The erase Vth dispersion is systematically simulated vs. process variations, confirming the sensitive role of edge profile in affecting F-N tunneling current. We also present a successful operation of 256Mb NOR flash MLC, fabricated with a 90 nm technology by SAP process.
Elongational flow of polymer melts (1972)

Abstract Elongational flow experiments with viscous polymeric material were conducted at a constant elongation rate on a modified tensile testing machine. Steady elongational and shear viscosity data and elongational stress growth data are presented for an isobutylene‐isoprene copolymer at 100°C. S‐shaped elongational stress growth curves are reported for cis‐1,4‐polyisoprene at 80°C. The stresses necessary to maintain a cylindrical specimen in steady elongational flow are indicated by a calculation which includes the effects of inertia, gravity, and interfacial tension. Interrelations among several elongational flow material functions are given for a constitutive equation based on the theory of linear viscoelasticity.
Expression of inflammatory cytokines in retina ischemia-reperfusion injury rats (2017)

Background: Through establishing a retina ischemia-reperfusion injury (RIRI) model, we observed the expression of inflammatory cytokines in retina to explore its possible role in the process of RIRI.
Methods: 75 healthy SD rats without eye disease were randomly divided into normal control group (NCG) and model group (MG).
Results: Protein expression of tumor necrosis factor-α (TNF-α), interleukin-23 (IL-23) and interleukin-17 (IL-17) enhanced obviously in RIRI retina. The TNF-α and IL-23 increased the most at 24 h after modeling, while IL-17 reached the peak at 72 h after modeling. RT-qPCR results showed that 12, 24, 72 and 144 hours after modeling, mRNA expression of TNF-α, IL-23 and IL-17 increased obviously in MG. The mRNA expression of TNF-α and IL-23 increased the most at 24 h after modeling, while IL-17 reached the peak at 72 h after modeling. The difference was significant (P<0.01).
Conclusions: Therefore, expression of TNF-α, IL-23 and IL-17 in retina enhanced obviously in RIRI SD rats. TNF-α, IL-23 and IL-17 can be viewed as pathogenic factors, involving in the pathological damage of RIRI through increasing retinal inflammation.
Immunoprecipitation Analysis of Soluble Complement-Fixing Antigens of Dengue Viruses (1970)

Abstract Soluble complement-fixing antigens were obtained from brains of suckling mice infected with each of the four dengue serotypes. Brain suspensions were partially purified by clarification with protamine sulfate, precipitation of the antigen with ammonium sulfate, and gel filtration on Sephadex G-100. Antigenic relationships of the partially purified antigens were examined by complement-fixation and Ouchterlony type immunoprecipitation. Discrete precipitin lines were formed with soluble complement-fixing antigens and hyperimmune mouse ascitic fluid. An antigenic determinant common to all four dengue serotypes was demonstrated by both complement-fixation and immunoprecipitation. Cross-absorption experiments confirmed the presence of the group antigen. Spur formation indicated the presence of a unique type-specific antigen for each serotype. Immunoprecipitation patterns indicated that both group- and type-specific antigenic determinants were on the same molecule and that separate antibodies were formed to each determinant.
Fault-Tolerant Voltage-Fed PWM Inverter AC Motor Drive Systems (2004)

This paper shows how to integrate fault compensation strategies into two different types of configurations of induction motor drive systems. The proposed strategies provide compensation for open-circuit and short-circuit failures occurring in the converter power devices. The fault compensation is achieved by reconfiguring the power converter topology with the help of isolating and connecting devices. These devices are used to redefine the post-fault converter topology. This allows for continuous free operation of the drive after isolation of the faulty power switches in the converter. Experimental results demonstrate the validity of the proposed systems.
A 140-element Ge detector fabricated with amorphous Ge blocking contacts (1994)

A 140-element position-sensitive Ge detector has been fabricated as the prototype detector for the development of a monochromatic computed tomography system using synchrotron radiation. The detector was made in very few processing steps that included the use of amorphous Ge blocking contacts. The fabrication process and the results of testing the detector are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Closed and Open Loop Subspace System Identification of the Kalman Filter (2009)

Some methods for consistent closed loop subspace system identification presented in the literature are analyzed and compared to a recently published subspace algorithm for both open as well as for closed loop data, the DSR e algorithm. Some new variants of this algorithm are presented and discussed. Simulation experiments are included in order to illustrate if the algorithms are variance efficient or not.
Phase noise measurements of six single- mode diode lasers (1981)

Recently there has been considerable interest in the output characteristics of single-mode solid-state diode lasers1 Measurements have been made of the diode laser's amplitude noise2 and spectral characteristics3 with and without optical feedback into the laser cavity. In this paper the low-frequency phase noise (related to the frequency stability of the laser) of six different diode lasers, both gain guided and index guided, has been Investigated; the frequency dependence of the phase noise has also been determined. The origin of the observed phase noise is discussed.
Carbon monoxide as a novel neuroendocrine modulator: inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants. (1994)

Although recent evidence suggests that the gas nitric oxide (NO) can modulate the secretion of corticotropin-releasing hormone (CRH) from acute rat hypothalamic explants, another gas, carbon monoxide (CO), has been suggested to play a role in neural signaling in the brain; CO may complement the activity of NO in long term potentiation. In this study, we have investigated whether CO shares with NO the ability to modify the release of CRH from the rat hypothalamus. Hemin, a specific CO precursor through the enzyme heme oxygenase (the enzymatic pathway synthesizing endogenous CO), was found to inhibit in a dose-dependent manner KCl-stimulated CRH release, with a maximal effect at 1 microM, while showing no effect on basal CRH secretion. The stimulation of CRH by interleukin-1 beta (100 ng/ml) was also significantly antagonized by hemin (1 microM). An inhibitor of heme oxygenase, zinc-protoporphyrin-9, had no effect on basal or stimulated CRH release up to a maximal dose of 10 microM. When hemin and zinc-protoporphyrin-9 were given together, the hemin-induced inhibition of CRH release was completely antagonized by the enzyme inhibitor. These findings provide evidence that endogenous CO may play a role in the control of CRH release; by analogy with NO, CO may represent a major new neuroendocrine modulator.
Mechanisms of myeloma cell growth control (1998)

Multiple myeloma is a progressive and fatal disease characterized by the accumulation of malignant plasma cells in the bone marrow. Normal plasma cells have long been viewed as end-stage cells that have lost the potential for further proliferation. The longevity of these cells has been estimated to range from several days to several weeks. 26 Recent evidence, however, raises the possibility that, under some circumstances, plasma cells may survive for a much longer period of time. 52 Myeloma cells differ considerably from normal plasma cells in that the tumor cells retain the capacity for proliferation and their lifespan may exceed that of normal counterpart cells, perhaps as a result of overexpression of several antiapoptotic cellular proteins. 21 Although tumor expansion in vivo is critically dependent upon both growth and death rates, this article focuses on several aspects of myeloma cell growth control.
An Overview of the Internet of Things Closed Source Operating Systems (2018)

The Internet of Things (IoT) attract a great deal of research and industry attention recently and are envisaged to support diverse emerging domains including intelligent transportation, smart cities, and health informatics. Operating system support for IoT plays a pivotal role in developing interoperable and scalable applications that are efficient and reliable. IoT is implemented by both high-end and low-end devices that require an operating system to run. Recently, we have witnessed a diversity of OSs emerging into IoT environment to facilitate IoT deployments and developments. In this paper, we present an overview of the common and existing closed source OSs for IoT. This paper is written in a tutorial style where each OS is described in details based on a set of designing and development aspects that we established. These aspects include architecture and kernel, memory management, scheduling, power consumption, networking protocols support, security, programming model, and multimedia support. The objective of this survey is to provide a well-structured guide to developers and researchers to determine the most appropriate OS for each specific IoT applications/devices based on their functional and non-functional requirements.
The effect of added polymers on the formation of drops ejected from a nozzle (2005)

The presence of small amounts of polymer in Newtonian solvents can have a significant impact on the flow behavior of these fluids in extension-dominated flows. This study investigates the effect of elasticity on the on-demand drop formation through the use of low viscosity elastic liquids. A high-speed camera is employed to observe drops ejected from a nozzle. The drops are created using a piezoelectric sleeve that contracts around a nozzle forcing fluid out. We observe that the satellite drops commonly produced with Newtonian fluids of identical shear viscosity in the same geometry can be suppressed when polymers with sufficient molecular weight are added. For our nozzle, the minimum required molecular weight is 300k PEO at a concentration of 25 ppm. However, the resultant increased elasticity in the solution requires a greater pulse strength to eject the drop. In addition, the fluids containing polymers have a longer thread, a longer time to separation, and a lower velocity than the Newtonian fluids with similar shear viscosity.
Influence of pH and added gums on the properties of konjac flour gels (2004)

Abstract The gel strength and texture of konjac gel and mixed gels of konjac and various gums were measured after gelation at various concentrations of alkali. A selection of different alkaline reagents was used. Regardless of alkali concentration, increasing konjac levels caused a decrease in pH but an increase in hardness and strength of konjac/gellan gum mixed gels. The highest gel strength and hardness were given by mixed konjac/gellan gum gels using sodium carbonate as the gelling medium. Under similar gelling conditions, the addition of gellan gum resulted in the greatest gel hardness. Of the gums examined, a possible synergistic effect on konjac/gellan gum mixed gel texture was observed.
Serial passage of tumors in mice in the study of tumor progression and testing of antineoplastic drugs. (1984)

AKR lymphoma cells derived from spontaneous tumors were serially transplanted at identical inocula. The degree of malignancy and sensitivity to the polysaccharide levan and methotrexate were tested at each transfer by assessing the lag of development of primary and distant tumors and survival of mice. A progressive increase in malignancy, accompanied by a loss of sensitivity to levan, were observed following serial passage of the lymphoma. Sensitivity to methotrexate was not affected. It is reasoned that, since serial passages permit a longer exposure of the tumor cells to selective forces of the internal milieu of the organism, better reflecting the situation in a long-life span animal, spontaneous and serial-passage tumors could serve as models for cancer therapy in humans.
Highly Satisfactory Procedures for the Pd-Catalyzed Cross Coupling of Aryl Electrophiles with in Situ Generated Alkynylzinc Derivatives (2001)

[reaction: see text] Two new and very efficient procedures (Procedures A and B) are reported for the Pd-catalyzed cross coupling of aryl electrophiles with terminal alkynes via their in situ conversion into alkynylzinc derivatives. Procedure A is particularly valuable in cases where electron-deficient alkynes are used, while Procedure B is operationally simple and very satisfactory in less demanding cases.
Oxidation/reduction potential of glutathione (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation/reduction potential of glutathioneKevin K. Millis, Kim H. Weaver, and Dallas L. RabensteinCite this: J. Org. Chem. 1993, 58, 15, 4144–4146Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/jo00067a060https://doi.org/10.1021/jo00067a060research-articleACS PublicationsRequest reuse permissionsArticle Views2529Altmetric-Citations116LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Method for subaperture testing interferogram reduction (1983)

Subaperture testing provides an attractive alternative to large monolithic test optics for evaluation of large optical systems. We present a method for reducing subaperture testing data that requires no a priori knowledge of the relative piston and tilt of the subapertures. Results of applying this method to analyze subaperture testing interferograms are presented. In particular, the behavior of this method in the presence of data noise and for different subaperture configurations is studied.
Rate determination algorithms in IS-95 forward traffic channels (2002)

According to the IS-95 CDMA standard, the transmit data rate can vary from frame to frame depending on the speech activity. However, the receiver does not know the data rate of the received frames. Conventionally, the receiver has to decode the received frame four times corresponding to the four possible data rates in rate set 1 or rate set 2 so as to obtain the correct decoded frame. Two rate determination algorithms for using 8 kbps (rate set 1) and 13 kbps (rate set 2) speech codecs in the forward traffic channel are introduced. The idea of maximum-likelihood estimation is employed in these two algorithms to determine the data rate. By using these algorithms, the received frame can be decoded once only corresponding to the determined rate instead of four times. Consequently, the decoding complexity and the power consumption at the receiver can be significantly reduced. From our analysis, the worst-case complexity and the average power consumption can be saved by a factor of 2 and 5, respectively.
Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals. (1995)

We have shown previously that the expression of collagenase is upregulated in rabbit synovial fibroblasts cultured on a substrate of antibody to the alpha 5 chain of the alpha 5 beta 1 integrin fibronectin receptor or on the 120-kD cell-binding chymotryptic fragment of plasma fibronectin, but remains at basal levels in cells plated on intact plasma fibronectin. We now have identified some of the components of a signaling pathway that couples the fibronectin receptor to the induction of collagenase transcription. We studied the control of collagenase gene expression in cells adhering to the 120-kD fragment of fibronectin, to antifibronectin receptor antibody, or to plasma fibronectin by transiently introducing promoter-reporter constructs into rabbit synovial fibroblasts before plating cells on these matrices. The constructs contained segments of the human collagenase promoter regulating transcription of chloramphenicol acyl transferase. Expression of constructs containing the -1200/-42-bp segment or the -139/-42-bp segment of the collagenase promoter inserted upstream from the reporter gene was induced to similar extents in cells plated on the 120-kD fragment of fibronectin or on anti-fibronectin receptor antibody, relative to that in fibroblasts plated on fibronectin. The expression of the construct containing the -66/-42-bp segment of the promoter was not regulated and was similar to that of the parent pBLCAT2 plasmid, suggesting that the -139/-67 region of the collagenase promoter, which contains PEA3- and AP1-binding sites, regulates the transcription of collagenase caused by integrin-derived signals. Expression of a reporter construct containing only the PEA3 and AP1 sites in the collagenase promoter (-90/-67) also increased in cells plated on the 120-kD fragment of fibronectin or on anti-fibronectin receptor antibody, relative to that in cells plated on fibronectin. Mutations in either the AP1 or PEA3 site of this minimal promoter abrogated its activity in cells plated on these inductive ligands. Expression of c-fos mRNA increased within 1 h of plating cells on the 120-kD fibronectin fragment or on anti-fibronectin receptor antibody, relative to that in cells plated on fibronectin. c-Fos protein accumulated in the nuclei of fibroblasts within 10 min of plating on the 120-kD fibronectin fragment. The increase in c-Fos was required for the increase in collagenase in cells plated on the 120-kD fibronectin fragment: incubation of cells with antisense, but not sense, c-fos oligonucleotides diminished both basal and induced expression of the -139/-42 collagenase promoter-reporter construct and decreased expression of the endogenous collagenase gene.(ABSTRACT TRUNCATED AT 400 WORDS)
Two Muscardine Fungi Pathogenic to Diaprepes Abbreviatus (1972)

In the laboratory, the fungus Metarrhizium anisopliae (Metschnikoff) Sorokin infected 6.7% of the adults and none of the larvae of the so-called sugarcane rootstalk borer weevil, Diaprepres abbreviatus (L.). In contrast, Beauveria bassiana (Balsamo) Vuillemin infected 92.7% of the adults within 7 days and 76.9% of the larvae within 12 days.