gebhart/patrepeval huggingface dataset:
Changes in expressions of proteasome and ubiquitin genes in human renal cancer cells. (1991)

Proteasomes and ubiquitin (Ub) are essential components of the energy-dependent, nonlysosomal proteolytic pathway. To clarify the physiological role of this proteasome/Ub-dependent pathway, we meaured the levels of expressions of proteasomes and Ub in human renal cancers by Northern blot and immunochemical analyses. The mRNAs for two of the multiple subunits of proteasomes, C2 and C9, were expressed at abnormally high levels in most neoplastic lesions of patients with various primary renal cell carcinomas and in all renal cancer cell lines examined. However, no significant difference was found by enzyme immunoassay in the proteasomal contents of cancerous and normal parts of the kidney. The levels of mRNAs for the subunits of proteasomes were high in rapidly proliferating renal cells and appeared to be correlated with the activities of these cells for proteasome synthesis, but the cellular contents of proteasomes in these cells were normal, suggesting rapid turnover of proteasomes in rapidly proliferating cancer cells. Consistent with the increased expressions of proteasomal mRNAs, the expressions of three Ub genes, mono-UbA80, mono-UbA52, and poly-UbC, were found to be greatly increased in these renal cancer cells. Immunohistochemical staining of normal kidney showed that the levels of both proteasomes and Ub were high in cells of renal tubules and collecting ducts, but low in the glomerulus. The levels of both proteins appeared to be considerably increased in the nuclei of granular and clear carcinoma cells of the kidney. Moreover, the profiles of cellular proteins conjugated with Ub in normal kidney tissues were different from those in cancerous parts of the kidney and in established renal cancer cells. These results suggest that the proteasome- and ubiquitin-mediated system is functionally involved in the cancerous state in human kidney.
Multi-hazard risk assessment : an interdependency approach (2010)

This research began with the Joint Infrastructure Interdependencies Research Program (JIIRP). JIIRP was part of an effort by the Government of Canada to fund research to develop innovative ways to mitigate large disaster situations. An interdependency simulator (I2Sim) was developed in the University of British Columbia through this project. This tool was developed to take into account the dynamic changes of the functional conditions of any given system. This thesis makes two major contributions to the capability of the simulator’s methodology, to handle seismic events and events that affect dense concentrations of people. The distinguishing characteristic of an earthquake event can affect the city and all the surrounding regions, causing damage to all lifeline systems. In its original form, I2Sim could model the damage and impact of each system on its own, but was unable to account for the effects of all other systems. The interdependency between systems is a crucial element for determining the impact of an earthquake and the time for recovery. The methodology proposed here can be used to measure Interdependencies and Resiliency in a region. Two cases were studied and implemented to test the methodology and the simulator. The first one was an earthquake hazard in a relatively small region (UBC Campus) in which the interdependencies and resiliency would be revealed to the emergency managers of UBC Campus; the second one, was a localized event in a massive sporting event (Winter Olympics in Vancouver), a black out in a Football Stadium that caused an uncontrolled egress, and related casualties due to a collapsing stage and the evacuation process were modelled. With the methodology and the simulator (I2Sim) it is possible to build up Region models, Disaster Scenarios, Objective Functions and Emergency Planning; and these, along with Interdependency and Resiliency calculations, will help in the preparedness, planning, response and recovery phases of any disaster.
<i>Inula Viscosa</i>Extracts Induces Telomere Shortening and Apoptosis in Cancer Cells and Overcome Drug Resistance (2016)

Telomerase is activated in human papillomavirus (HPV) positive cervical cancer and targeting telomeres offers a novel anticancer therapeutic strategy. In this study, the telomere targeting properties, the cytotoxic as well as the pro-apoptotic effects of hexane (IV-HE) and dichloromethane (IV-DF) fractions from Inula viscosa L. extracts were investigated on human cervical HeLa and SiHa cancer cells. Our data demonstrate that IV-HE and IV-DF extracts were able to inhibit cell growth in HeLa and SiHa cells in a dose-dependent manner and studied resistant cell lines exhibited a resistance factor less than 2 when treated with the extracts. IV-HE and IV-DF extracts were able to inhibit telomerase activity and to induce telomere shortening as shown by telomeric repeat amplification protocol and TTAGGG telomere length assay, respectively. The sensitivity of fibroblasts to the extracts was increased when telomerase was expressed. Finally, IV-HE and IV-DF were able to induce apoptosis as evidenced by an increase in annexin-V labeling and caspase-3 activity. This study provides the first evidence that the IV-HE and IV-DF extracts from Inula viscosa L. target telomeres induce apoptosis and overcome drug resistance in tumor cells. Future studies will focus on the identification of the molecules involved in the anticancer activity.
Compromising emanations: eavesdropping risks of computer displays (2021)

Electronic equipment can emit unintentional signals from which eavesdroppers may reconstruct processed data at some distance. This has been a concern for military hardware for over half a century. The civilian computer-security community became aware of the risk through the work of van Eck in 1985. Military “Tempest” shielding test standards remain secret and no civilian equivalents are available at present. The topic is still largely neglected in security textbooks due to a lack of published experimental data. This report documents eavesdropping experiments on contemporary computer displays. It discusses the nature and properties of compromising emanations for both cathode-ray tube and liquid-crystal monitors. The detection equipment used matches the capabilities to be expected from well-funded professional eavesdroppers. All experiments were carried out in a normal unshielded office environment. They therefore focus on emanations from display refresh signals, where periodic averaging can be used to obtain reproducible results in spite of varying environmental noise. Additional experiments described in this report demonstrate how to make information emitted via the video signal more easily receivable, how to recover plaintext from emanations via radio-character recognition, how to estimate remotely precise video-timing parameters, and how to protect displayed text from radio-frequency eavesdroppers by using specialized screen drivers with a carefully selected video card. Furthermore, a proposal for a civilian radio-frequency emission-security standard is outlined, based on path-loss estimates and published data about radio noise levels. Finally, a new optical eavesdropping technique is demonstrated that reads CRT displays at a distance. It observes high-frequency variations of the light emitted, even after diffuse reflection. Experiments with a typical monitor show that enough video signal remains in the light to permit the reconstruction of readable text from signals detected with a fast photosensor. Shot-noise calculations provide an upper bound for this risk.
Ring‐opening polymerization of 1,3‐benzoxazines by <i>p</i>‐toluenesulfonates as thermally latent initiators (2011)

Abstract p ‐Toluenesulfonic acid (TsOH) and several alkyl p ‐toluenesulfonates, that is, methyl p ‐toluenesulfonate (TsOMe), cyclohexyl p ‐toluenesulfonate (TsOCH), and neopentyl p ‐toluenesulfonate (TsONP), were evaluated as initiators for the ring‐opening polymerization of benzoxazines. TsOH and TsOMe were highly efficient initiators that induced the polymerization at 60 and 80 °C, respectively. In contrast, TsOCH and TsONP did not initiate the polymerization below 100 °C, while they induced the polymerization at elevated temperatures, 120 and 150 °C, respectively. When TsOCH was used as an initiator, the corresponding polymerization rate was comparable to that observed for the polymerization with using TsOH as an initiator. These results suggested that neutral TsOCH and TsONP can be regarded as “thermally latent initiators,” which underwent the thermal dissociation at the elevated temperatures to generate the corresponding alkyl cations and/or TsOH as the initiators of the polymerization. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
<title>Characteristic Views As A Basis For Three-Dimensional Object Recognition</title> (1982)

This paper describes a new technique for modeling 3D objects that is applicable to recog-nition tasks in advanced automation. Objects are represented in terms of canonic 2D models which can be used to determine the identity, location and orientation of an unknown object. The reduction in dimensionality is achieved by factoring the space of all possible perspective projections of an object into a set of characteristic views, where each such view defines a characteristic-view domain within which all projections are topologically identical and related by a linear transformation. The characteristic views of an object can then be hierarchically structured for efficient classification. The line-junction labelling constraints are used to match a characteristic view to a given unknown-object projection, and determination of the unknown-object projection-to-characteristic view transformation then provides information about the identity as well as the location and orientation of the object.
Dietary arginine level and tritiated thymidine incorporation into dna in normal and regenerating liver of weanling rats (1986)

Male weanling Sprague-Dawley rats were fed graded amounts of arginine (0.25% - 2%) in a crystalline L-amino acid diet for 10 days. Feed intake was decreased only in the rats receiving 0.25% Arg in the diet. Weight gain and growth efficiency were lower in the rats receiving 0.25% and 0.5% dietary arginine. Orotic acid excretion was elevated 400 fold in the rats receiving less than 1% dietary arginine. Liver weights were not significantly different among groups. DNA concentration/g liver was 10% lower in the rats receiving 0.25% dietary arginine. Rats receiving less than 1% arginine had 17% less RNA/g liver and 77% less /sup 3/H-thymidine incorporation into liver DNA. After partial hepatectomy (PH) /sup 3/H-thymidine incorporation into liver DNA was increased by 23% on rats receiving 0.5 dietary arginine compared to sham operated controls (SOC) receiving the same diet. Incorporation of /sup 3/H-thymidine was unchanged in PH rats as compared with SOC rats receiving 0.25% Arg. These data indicate that at least 1% of dietary arginine is required to maintain normal protein metabolism in growing male rats. There were no significant differences in any of the parameters measured when dietary Arg was 1% or 2% of the diet.
La Triangulación Metodológica en Ciencias Sociales (2002)

This paper aims to present some characteristics and advantages of combined and complementary use of both qualitative and qualitative approaches in social research. It is based on learnings and difficulties ecountered in the development of a research project on youth and insecurity, titled "Certainties threatened. A study on the reach of insecurity among youth". That work was basically a qualitative study. Its central goal was to examine the significate that different sources of security -such as work, education, family, the street, and certain social institutions- have to youth people. However, this analysis of subjective attributes (perceptions, attitudes, opinions, representations, assessments) was done taking into account certain structural data from local socioeconomic reality. That means that it was intended to enrich the qualitative analysis based on interviews with a quantitative analysis of public census and surveys. Such combination of approaches allowed a broad and integrated examination of the phenomenon studied, and permited us to explore some coincidencies and differences between isecurity’s structural-objective and subjective aspects.
Vulcanization of Saturated Acrylic Resins (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVulcanization of Saturated Acrylic ResinsW. C. Mast, C. E. Rehberg, T. J. Dietz, and C. H. FisherCite this: Ind. Eng. Chem. 1944, 36, 11, 1022–1027Publication Date (Print):November 1, 1944Publication History Published online1 May 2002Published inissue 1 November 1944https://pubs.acs.org/doi/10.1021/ie50419a012https://doi.org/10.1021/ie50419a012research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Summary Abstract: Characterization of ion beam deposited diamondlike carbon coating on semiconductors (1985)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation P. V. Koeppe, V. J. Kapoor, M. J. Mirtich, B. A. Banks, D. A. Gulino; Summary Abstract: Characterization of ion beam deposited diamondlike carbon coating on semiconductors. Journal of Vacuum Science & Technology A 1 November 1985; 3 (6): 2327–2328. https://doi.org/10.1116/1.572875 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science & Technology A Search Advanced Search |Citation Search
Researches on Phenylhydantoins<sup>1</sup> (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTResearches on Phenylhydantoins1Henry R. Henze and Loren M. LongCite this: J. Am. Chem. Soc. 1941, 63, 7, 1936–1938Publication Date (Print):July 1, 1941Publication History Published online1 May 2002Published inissue 1 July 1941https://pubs.acs.org/doi/10.1021/ja01852a040https://doi.org/10.1021/ja01852a040research-articleACS PublicationsRequest reuse permissionsArticle Views88Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study (2017)

<b>Objectives</b> To investigate whether moderate alcohol consumption has a favourable or adverse association or no association with brain structure and function.<b>Design</b> Observational cohort study with weekly alcohol intake and cognitive performance measured repeatedly over 30 years (1985-2015). Multimodal magnetic resonance imaging (MRI) was performed at study endpoint (2012-15).<b>Setting</b> Community dwelling adults enrolled in the Whitehall II cohort based in the UK (the Whitehall II imaging substudy).<b>Participants</b> 550 men and women with mean age 43.0 (SD 5.4) at study baseline, none were "alcohol dependent" according to the CAGE screening questionnaire, and all safe to undergo MRI of the brain at follow-up. Twenty three were excluded because of incomplete or poor quality imaging data or gross structural abnormality (such as a brain cyst) or incomplete alcohol use, sociodemographic, health, or cognitive data.<b>Main outcome measures</b> Structural brain measures included hippocampal atrophy, grey matter density, and white matter microstructure. Functional measures included cognitive decline over the study and cross sectional cognitive performance at the time of scanning.<b>Results</b> Higher alcohol consumption over the 30 year follow-up was associated with increased odds of hippocampal atrophy in a dose dependent fashion. While those consuming over 30 units a week were at the highest risk compared with abstainers (odds ratio 5.8, 95% confidence interval 1.8 to 18.6; P≤0.001), even those drinking moderately (14-21 units/week) had three times the odds of right sided hippocampal atrophy (3.4, 1.4 to 8.1; P=0.007). There was no protective effect of light drinking (1-<7 units/week) over abstinence. Higher alcohol use was also associated with differences in corpus callosum microstructure and faster decline in lexical fluency. No association was found with cross sectional cognitive performance or longitudinal changes in semantic fluency or word recall.<b>Conclusions</b> Alcohol consumption, even at moderate levels, is associated with adverse brain outcomes including hippocampal atrophy. These results support the recent reduction in alcohol guidance in the UK and question the current limits recommended in the US.
Tranexamic acid–associated seizures: Causes and treatment (2015)

Antifibrinolytic drugs are routinely used worldwide to reduce the bleeding that results from a wide range of hemorrhagic conditions. The most commonly used antifibrinolytic drug, tranexamic acid, is associated with an increased incidence of postoperative seizures. The reported increase in the frequency of seizures is alarming, as these events are associated with adverse neurological outcomes, longer hospital stays, and increased in-hospital mortality. However, many clinicians are unaware that tranexamic acid causes seizures. The goal of this review is to summarize the incidence, risk factors, and clinical features of these seizures. This review also highlights several clinical and preclinical studies that offer mechanistic insights into the potential causes of and treatments for tranexamic acid-associated seizures. This review will aid the medical community by increasing awareness about tranexamic acid-associated seizures and by translating scientific findings into therapeutic interventions for patients.
[Immunohistochemical localization of herpes simplex virus type 1 in experimental retinitis--2. The brain, contralateral optic nerve and retina]. (1994)

Unilateral intravitreal inoculation of herpes simplex virus type 1 (HSV) induced bilateral retinitis and encephalitis in rats. In a previous paper, we demonstrated immunohistochemical localization of HSV in the ipsilateral retina. In this paper, we report immunohistochemical localization of antigen to HSV in the brain and opposite eye. HSV was found in the optic chiasm, and bilaterally in the suprachiasmatic nuclei, lateral geniculate nuclei, superior colliculus, pretectum, and visual cortex. HSV was also found in the retinal ganglion cells, neural cells in the inner nuclear layer, and Müller cells in the opposite eye. We demonstrated HSV infection in the retina of the opposite eye via the optic nerve, visual pathway, and nuclei, but not through the blood stream.
Compilation of the Pascal case statement (1982)

Abstract Pascal case statements can be compiled using a variety of methods, including comparison trees and branch tables. The scheme discussed here combines the two techniques to allow comparison trees with entries that are branch tables. The use of a combination of the two techniques is shown to adapt well to certain instances of case statements. Extensions to the standard case statement also require such a scheme to obtain an efficient implementation.
Protective antifungal memory CD8+ T cells are maintained in the absence of CD4+ T cell help and cognate antigen in mice (2012)

Individuals who are immunocompromised, including AIDS patients with few CD4(+) T cells, are at increased risk for opportunistic fungal infections. The incidence of such infections is increasing worldwide, meaning that the need for antifungal vaccines is increasing. Although CD4(+) T cells play a dominant role in resistance to many pathogenic fungal infections, we have previously shown that vaccination can induce protective antifungal CD8(+) T cell immunity in the absence of CD4(+) T cells. However, it has not been determined whether vaccine-induced antifungal CD8(+) T cell memory can be maintained in the absence of CD4(+) T cell help. Here, we have shown in a mouse model of vaccination against blastomycosis that antifungal memory CD8(+) T cells are maintained in the absence of CD4(+) T cells without loss of numbers or function for at least 6 months and that the cells protect against infection. Using a system that enabled us to induce and track antigen-specific, antifungal CD8(+) T cells, we found that such cells were maintained for at least 5 months upon transfer into naive mice lacking both CD4(+) T cells and persistent fungal antigen. Additionally, fungal vaccination induced a profile of transcription factors functionally linked with persistent memory in CD8(+) T cells. Thus, unlike bacteria and viruses, fungi elicit long-term CD8(+) T cell memory that is maintained without CD4(+) T cell help or persistent antigen. This has implications for the development of novel antifungal vaccine strategies effective in immunocompromised patients.
LARGE-AREA FLOW COUNTERS SPEED RADIATION MEASUREMENTS (1961)

A multichannel nulling or subtraction technique for minimizing or eliminating vertical and/or horizontal eye movement artifact including blinks in EEG recordings is described. The circuit, which makes use of principles previously described by other workers, is intended to function integrally with contemporary electroencephalographs, and is relative simple in design and easy to implement.