gebhart/patrepeval huggingface dataset:
Spectral characteristics of ventricular response to atrial fibrillation (1997)

To investigate the spectral characteristics of the fluctuation in ventricular response during atrial fibrillation (AF), R-R interval time series obtained from ambulatory electrocardiograms were analyzed in 45 patients with chronic AF and in 30 age-matched healthy subjects with normal sinus rhythm (SR). Although the 24-h R-R interval spectrum during SR showed a 1/f noise-like downsloping linear pattern when plotted as log power against log frequency, the spectrum during AF showed an angular shape with a breakpoint at a frequency of 0.005 +/- 0.002 Hz, by which the spectrum was separated into long-term and short-term components with different spectral characteristics. The short-term component showed a white noise-like flat spectrum with a spectral exponent (absolute value of the regression slope) of 0.05 +/- 0.08 and an intercept at 10(-2) Hz of 4.9 +/- 0.3 log(ms2/Hz). The long-term component had a 1/f noise-like spectrum with a spectral exponent of 1.26 +/- 0.40 and an intercept at 10(-4) Hz of 7.0 +/- 0.3 log(ms2/Hz), which did not differ significantly from those for the spectrum during SR in the same frequency range [spectral exponent, 1.36 +/- 0.06; intercept at 10(-4) Hz, 7.1 +/- 0.3 log(ms2/Hz)]. The R-R intervals during AF may be a sequence of uncorrelated values over the short term (within several minutes). Over the longer term, however, the R-R interval fluctuation shows the long-range negative correlation suggestive of underlying regulatory processes, and spectral characteristics indistinguishable from those for SR suggest that the long-term fluctuations during AF and SR may originate from similar dynamics of the cardiovascular regulatory systems.
High-resolution mapping of the 11q13 amplicon and identification of a gene, <i>TAOS1</i> , that is amplified and overexpressed in oral cancer cells (2002)

Amplification of chromosomal band 11q13 is a common event in human cancer. It has been reported in about 45% of head and neck carcinomas and in other cancers including esophageal, breast, liver, lung, and bladder cancer. To understand the mechanism of 11q13 amplification and to identify the potential oncogene(s) driving it, we have fine-mapped the structure of the amplicon in oral squamous cell carcinoma cell lines and localized the proximal and distal breakpoints. A 5-Mb physical map of the region has been prepared from which sequence is available. We quantified copy number of sequence-tagged site markers at 42-550 kb intervals along the length of the amplicon and defined the amplicon core and breakpoints by using TaqMan-based quantitative microsatellite analysis. The core of the amplicon maps to a 1.5-Mb region. The proximal breakpoint localizes to two intervals between sequence-tagged site markers, 550 kb and 160 kb in size, and the distal breakpoint maps to a 250 kb interval. The cyclin D1 gene maps to the amplicon core, as do two new expressed sequence tag clusters. We have analyzed one of these expressed sequence tag clusters and now report that it contains a previously uncharacterized gene, TAOS1 (tumor amplified and overexpressed sequence 1), which is both amplified and overexpressed in oral cancer cells. The data suggest that TAOS1 may be an amplification-dependent candidate oncogene with a role in the development and/or progression of human tumors, including oral squamous cell carcinomas. The approach described here should be useful for characterizing amplified genomic regions in a wide variety of tumors.
Estimation of Hydrogen-Exchange Protection Factors from MD Simulation Based on Amide Hydrogen Bonding Analysis (2015)

Hydrogen exchange (HX) studies have provided critical insight into our understanding of protein folding, structure, and dynamics. More recently, hydrogen exchange mass spectrometry (HX-MS) has become a widely applicable tool for HX studies. The interpretation of the wealth of data generated by HX-MS experiments as well as other HX methods would greatly benefit from the availability of exchange predictions derived from structures or models for comparison with experiment. Most reported computational HX modeling studies have employed solvent-accessible-surface-area based metrics in attempts to interpret HX data on the basis of structures or models. In this study, a computational HX-MS prediction method based on classification of the amide hydrogen bonding modes mimicking the local unfolding model is demonstrated. Analysis of the NH bonding configurations from molecular dynamics (MD) simulation snapshots is used to determine partitioning over bonded and nonbonded NH states and is directly mapped into a protection factor (PF) using a logistics growth function. Predicted PFs are then used for calculating deuteration values of peptides and compared with experimental data. Hydrogen exchange MS data for fatty acid synthase thioesterase (FAS-TE) collected for a range of pHs and temperatures was used for detailed evaluation of the approach. High correlation between prediction and experiment for observable fragment peptides is observed in the FAS-TE and additional benchmarking systems that included various apo/holo proteins for which literature data were available. In addition, it is shown that HX modeling can improve experimental resolution through decomposition of in-exchange curves into rate classes, which correlate with prediction from MD. Successful rate class decompositions provide further evidence that the presented approach captures the underlying physical processes correctly at the single residue level. This assessment is further strengthened in a comparison of residue resolved protection factor predictions for staphylococcal nuclease with NMR data, which was also used to compare prediction performance with other algorithms described in the literature. The demonstrated transferable and scalable MD based HX prediction approach adds significantly to the available tools for HX-MS data interpretation based on available structures and models.
Learn to See by Events: Color Frame Synthesis from Event and RGB Cameras (2020)

Event cameras are biologically-inspired sensors that gather the temporal evolution of the scene. They capture pixel-wise brightness variations and output a corresponding stream of asynchronous events. Despite having multiple advantages with respect to traditional cameras, their use is partially prevented by the limited applicability of traditional data processing and vision algorithms. To this aim, we present a framework which exploits the output stream of event cameras to synthesize RGB frames, relying on an initial or a periodic set of color key-frames and the sequence of intermediate events. Differently from existing work, we propose a deep learning-based frame synthesis method, consisting of an adversarial architecture combined with a recurrent module. Qualitative results and quantitative per-pixel, perceptual, and semantic evaluation on four public datasets confirm the quality of the synthesized images.
Stepwise Modulation of Neurokinin-3 and Neurokinin-2 Receptor Affinity and Selectivity in Quinoline Tachykinin Receptor Antagonists (2001)

A stepwise chemical modification from human neurokinin-3 receptor (hNK-3R)-selective antagonists to potent and combined hNK-3R and hNK-2R antagonists using the same 2-phenylquinoline template is described. Docking studies with 3-D models of the hNK-3 and hNK-2 receptors were used to drive the chemical design and speed up the identification of potent and combined antagonsits at both receptors. (S)-(+)-N-(1-Cyclohexylethyl)-3-[(4-morpholin-4-yl)piperidin-1-yl]methyl-2-phenylquinoline-4-carboxamide (compound 25, SB-400238: hNK-3R binding affinity, K(i) = 0.8 nM; hNK-2R binding affinity, K(i) = 0.8 nM) emerged as the best example in this approach. Further studies led to the identification of (S)-(+)-N-(1,2,2-trimethylpropyl)-3-[(4-piperidin-1-yl)piperidin-1-yl]methyl-2-phenylquinoline-4-carboxamide (compound 28, SB-414240: hNK-3R binding affinity, K(i) = 193 nM; hNK-2R binding affinity, K(i) = 1.0 nM) as the first hNK-2R-selective antagonist belonging to the 2-phenylquinoline chemical class. Since some members of this chemical series showed a significant binding affinity for the human mu-opioid receptor (hMOR), docking studies were also conducted on a 3-D model of the hMOR, resulting in the identification of a viable chemical strategy to avoid any significant micro-opioid component. Compounds 25 and 28 are therefore suitable pharmacological tools in the tachykinin area to elucidate further the pathophysiological role of NK-3 and NK-2 receptors and the therapeutic potential of selective NK-2 (28) or combined NK-3 and NK-2 (25) receptor antagonists.
Investigations into the polymorphisms at the <i>ECM38</i> locus of two widely used <i>Saccharomyces cerevisiae</i> S288C strains, YPH499 and BY4742 (2003)

The ECM38 gene encodes the gamma-glutamyl transpeptidase enzyme, an enzyme involved in glutathione turnover. The enzyme was found to be present in the S288C strain, BY4742, but absent in another widely used strain congenic to S288C, YPH499. Cloning and sequencing the genes from these yeasts indicated the presence of 11 single nucleotide polymorphisms in the coding region and eight single nucleotide polymorphisms in the promoter region of the ECM38 gene of YPH499 (but none in that of BY4742). One of the SNPs in the ECM38 ORF led to a G --> D conversion in a region conserved in all gamma-GT enzymes and was found to be responsible for the loss of activity in this strain. The presence of gamma-GT activity in other YPH strains led us to trace the origins of the polymorphisms in YPH499. Our results indicated that among the progenitor strains, YPH1 and YPH2, YPH1 carried the polymorphisms seen in YPH499 and also lacked the gamma-GT activity. The implications of these results for the use of these widely used S288C strains and the origin of these single nucleotide polymorphisms are presented.
Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa (2004)

This study shows that activation of STAT-1 by IFN-gamma promotes T-bet in CD mucosa.
A new on-chip converter for submicrometer high-density DRAMs (1987)

The converter described is a feedback-type voltage regulator which supplies a reduced voltage to an entire RAM circuit. A novel timing activation method was introduced to save power. The converter has been implemented on an experimental 4-Mb dynamic RAM. It was found that an even faster access time and higher reliability compared to a conventional design could be achieved by using an on-chip voltage converter and shorter channel transistors. This voltage converter is suitable for high-density, high-speed, and high-reliability DRAMs with submicrometer transistors.
Properties of formaldehyde-treated nucleohistone (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProperties of formaldehyde-treated nucleohistoneDouglas Brutlag, Cameron Schlehuber, and James BonnerCite this: Biochemistry 1969, 8, 8, 3214–3218Publication Date (Print):August 1, 1969Publication History Published online1 May 2002Published inissue 1 August 1969https://pubs.acs.org/doi/10.1021/bi00836a013https://doi.org/10.1021/bi00836a013research-articleACS PublicationsRequest reuse permissionsArticle Views378Altmetric-Citations141LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A MICROSCALE VAPOR-FED FORMIC ACID FUEL CELL (2004)

A silicon-based microfabricated fuel cell running on formic acid vapor as a fuel has been developed to provide on-chip power for MEMS devices, without using any ancillary devices such as heaters, water management, air pumps, etc. As a demonstration instrument, an integrated silicon-based membrane electrode assembly and fuel evaporative structure was packaged in a plastic package to test the vapor-fed fuel cell concept. Initial results (0.4
Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation (2019)

We previously engineered the β-subunit of tryptophan synthase (TrpB), which catalyzes the condensation of l-serine and indole to l-tryptophan, to synthesize a range of noncanonical amino acids from l-serine and indole derivatives or other nucleophiles. Here we employ directed evolution to engineer TrpB to accept 3-substituted oxindoles and form C-C bonds leading to new quaternary stereocenters. Initially, the variants that could use 3-substituted oxindoles preferentially formed N-C bonds on N<sub>1</sub> of the substrate. Protecting N<sub>1</sub> encouraged evolution toward C-alkylation, which persisted when protection was removed. Six generations of directed evolution resulted in TrpB <i>Pf</i><sub>quat</sub> with a 400-fold improvement in activity for alkylation of 3-substituted oxindoles and the ability to selectively form a new, all-carbon quaternary stereocenter at the γ-position of the amino acid products. The enzyme can also alkylate and form all-carbon quaternary stereocenters on structurally similar lactones and ketones, where it exhibits excellent regioselectivity for the tertiary carbon. The configurations of the γ-stereocenters of two of the products were determined via microcrystal electron diffraction (MicroED), and we report the MicroED structure of a small molecule obtained using the Falcon III direct electron detector. Highly thermostable and expressed at >500 mg/L <i>E. coli</i> culture, TrpB <i>Pf</i><sub>quat</sub> offers an efficient, sustainable, and selective platform for the construction of diverse noncanonical amino acids bearing all-carbon quaternary stereocenters.
Oral Urografin in Postoperative Small Bowel Obstruction (1999)

Abstract. The aim of our study was to determine whether Urografin has the potential to offer surgeons a way of differentiating complete from partial small bowel obstruction and whether partial small bowel obstruction can be treated nonoperatively. Altogether 116 patients who had postoperative small bowel obstructions without any toxic signs underwent Urografin studies. Urografin (40 ml) mixed with 40 ml of distilled water was administrated either orally or via nasogastric tube to each patient. Serial plain abdominal radiographs were taken 2, 4, and 8 hours later. A total of 74 patients (63.8%) whose contrast medium reached the colon within the first 8 hours were considered to have partial obstruction and were successfully treated with intravenous hydration and nasogastric decompression. The remaining 42 patients (36.2%) in whom the contrast medium failed to reach the colon within the first 8 hours were regarded as having complete obstruction, and 34 of those patients (81.0%) underwent surgery; 8 (19.0%) received conservative treatment. Adhesion bands with complete bowel obstruction were observed in all 34 patients (100.0%) during laparotomy. Regardless of the presence of an air‐fluid level on a plain abdominal radiograph or abdominal pain, a liquid diet followed by a soft diet could be given to those patients whose Urografin emptied into the colon. All the patients with partial bowel obstruction were treated successfully with nonoperative methods. The presence of Urografin in the colon within 8 hours of ingestion as an indicator for nonoperative treatment had a sensitivity of 90.2%, a specificity of 100%, and an accuracy of 93.1%. Urografin, a safe and reliable water‐soluble contrast medium, can be used to differentiate partial intestinal obstruction from complete intestinal obstruction. Early oral intake was found to be a major advantage of Urografin use in this study, and the potential of Urografin use to shorten the period of conservative treatment for postoperative small bowel obstruction needs further investigation.
Stereotactic Thalamotomy in the Human (1960)

The use of chronically implanted electrodes for the treatment of pain accompanying terminal carcinoma<sup>1</sup>has made it possible to investigate some aspects of thalamic function in the unanesthetized human. Following the first use of the stereotactic technique in the human by Kirschner in Germany in 1933, the work of Spiegel and Wycis in this country and of such workers as Leksell in Sweden, Riechert and Hassler in Germany, Talairach in France, and Narabayashi in Japan has well demonstrated the value of this method, not only for the clinical goal of producing discrete lesions in intracerebral structures, but also for investigating those brain functions which can be revealed by direct electrical stimulation. The work of Heath and collaborators<sup>2</sup>in demonstrating the feasibility of utilizing electrodes left in situ for weeks or months makes it possible to apply in man the principles initiated by Hess during many years of
Sort Middle Pipeline Architecture for Efficient 3D Rendering (2007)

This paper presents a high performance fixed function 3D graphics pipeline based on sort-middle computing paradigm. The proposed architecture implements the full specification of the OpenGL|ES 1.1 open standard and is specifically designed for a cost effective integration on consumer devices, in particular on low-power mobile ones.
The Anti Swing Strategy of Davit System to Unmanned Surface Vehicle at Sea (2020)

Abstract Aiming at the problem that the marine mother ship's davit system cannot accurately and quickly hoist due to wind and waves during the process of recovering the unmanned boat, an anti-swaying gondolas recovery system is designed to realize the automatic hoisting and deployment of the unmanned boat for recovery or deployment. We created a tension-length gondola recovery and deployment system model, which reduced the swing angle of the unmanned boat davit system's hoisting and deployment through adaptive control of the tension and length of the davit ropes, thereby realizing the installation and deployment of unmanned maritime boats at sea. It’s accurate and fast. Simulation experiments show that under the combined action conditions of 10 ° roll angle and 5 ° pitch angle, the deflection range of the gondola system equipped with a deflection device can reach about 60%.
Altered Dynamics of Candida albicans Phagocytosis by Macrophages and PMNs When Both Phagocyte Subsets Are Present (2013)

Extensive work investigating fungal cell phagocytosis by macrophages and PMNs of the innate immune system has been carried out. These studies have been informative but have examined this phenomenon only when one phagocyte subset is present. The current study employed live-cell video microscopy to break down C. albicans phagocytosis into its component parts and examine the effect of a single phagocyte subset, versus a mixed phagocyte population, on these individual stages. Through this approach, we identified that the rate of fungal cell engulfment and rate of phagocyte killing altered significantly when both macrophages and PMNs were incubated in coculture with C. albicans compared to the rate of either phagocyte subset incubated alone with the fungus. This research highlights the significance of studying pathogen-host cell interactions with a combination of phagocytes in order to gain a greater understanding of the interactions that occur between cells of the host immune system in response to fungal invasion.
<title>Observation of spontaneously grown domain structure in SBO crystals via nonlinear diffraction</title> (2007)

Partially ordered domain structure is detected for the first time in non-ferroelectric strontium tetraborate crystal via nonlinear diffraction. Domains have the form of sheets with the domain walls oriented perpendicularly to the α crystallographic axis. The thickness of domains is the random quantity; the spatial Fourier spectrum of the nonlinear susceptibility protrudes from π/6 to π/0.2 μm<sup>-1</sup>.
Chemical Synthesis of Graphite Perfluorooctanesulfonate Using K<sub>2</sub>MnF<sub>6</sub> in Hydrofluoric Acid or Mixed Acid Solutions (1999)

Graphite intercalation compounds (GICs) of nominal composition CxC8F17SO3·yF are prepared under ambient conditions in 48% hydrofluoric acid, using the oxidant K2MnF6. The product compositions are evaluated by mass uptake, TGA, DSC, and elemental analysis. PXRD analysis indicates that the stable product after 3−4 day reaction (x ≅ 18, y ≅ 4) is a GIC comprised of a solid solution of stage 2 and stage 3. A similar product, although containing a greater graphite fluoride impurity, can be obtained within 1 h using this method at 50 °C. Longer reactions at elevated temperature lead to product degradation and other impurities. The addition of up to 83 vol % concentrated HNO3 or 17% fuming H2SO4 produces a stage 2 intercalation compound within hours. One-dimensional structural modeling for the stage 2 GIC provides refined values for the graphene carbon/intercalant mole ratio, distance between graphene and sulfonate oxygen planes, position of additional intercalated fluoride, and the chain takeoff angle. The products obtained by this synthetic method and the observed staging phenomena are related to previous reports on graphite fluorometalates and an energetic model for graphite intercalation.
Expression of core binding factor alpha1 up-regulated by IGF-I, GM-CSF, and EGF through MAPK pathway in MC3T3-E1 and C2C12 cells. (2003)

IGF-I, GM-CSF, and EGF could increase the promoter activity and the mRNA expression of murine Cbfalpha1 gene in MC3T3-E1 and C2C12 cells. These stimulatory effects might be mediated by activating the intracellular MAPK-dependent signaling pathway.
Kernel and shell based applications integrity assurance (2002)

The verification of the authenticity of software by an executing host has become a vital security issue in recent years with the original postulation and subsequent evolution of computer viruses. The CASS (Computer Architecture for Secure Systems) project addresses this issue by incorporating integrity checking at the operating system level. This paper describes three prototype implementations of the architecture, two of these at the kernel level targetting UNIX SVR4.2 and the Mach 3.0 microkernel, with the third-for reasons of generality-involving the implementation of a specialised shell which is then portable across UNIX-style platforms in general. The paper focusses on a description of the former, viz. the kernel-based implementations, and examines the design and implementation issues which had to be addressed in achieving kernel-based integrity checking of executables for the two platforms.