gebhart/patrepeval huggingface dataset:
Abstract 2453: Effect of Ranolazine on Hemoglobin A1c in the MERLIN-TIMI 36 Randomized Controlled Trial (2007)

Seven steroid epoxides were prepared from 5α-pregn-2-en-20-one and 5α-pregn-3-en-20-one and their side-chain derivatives. All compounds were tested in vitro for binding to γ-aminobutyric acid (GABAA) receptor, some of them also in vivo for anticonvulsant action. 2α,3α-Epoxy-5α-pregnan-20-one inhibited the TBPS binding to the GABAA receptor and showed a moderate anticonvulsant action in immature rats. In contrast, its 3α,4α-isomer was inactive. More polar epoxide derivatives, modified at the side chain were less active or inactive. Noteworthy, diol 20, the product of trans-diaxial opening of the 2α,3α-epoxide 4, was not able to inhibit the TBPS binding, showing that the activity of the epoxide is due to the compound itself and not to its hydrolytic product. The 3α-hydroxyl group is known to be essential for the GABAA receptor binding. Despite the shortness of in vivo effects which are probably due to metabolic inactivation of the products prepared, our results show that the 2α,3α-epoxy ring is another structural pattern with ability to bind the GABAAR.
Demonstration of a high-spectral-resolution lidar based on an iodine absorption filter (1994)

A high-spectral-resolution lidar that uses an iodine absorption filter and a tunable, narrow-bandwidth Nd:YAG laser is demonstrated. Measurements of aerosol scattering cross section and optical depth are presented. The iodine absorption filter provides better performance than the Fabry–Perot étalon that it replaces.
Diagnostic relevance of peripheral blood immunocytochemistry in hairy cell leukaemia. (1995)

AIMS--(1) To assess the diagnostic relevance of peripheral blood immunocytochemistry in hairy cell leukaemia (HCL); (2) to compare the immunostaining of bone marrow biopsy specimens with bone marrow and peripheral blood cytospins; (3) to evaluate the sensitivity of the different markers used; (4) to identify the ultrastructural localisation of DBA.44 in HCL variant. METHODS--Immunoenzymatic staining procedures, immunoperoxidase and immunoalkaline phosphatase, were used with a panel of monoclonal antibodies directed to HCL associated antigens. Ultrastructural immunostaining was performed using colloidal gold conjugated antibodies. RESULTS--HCL showed strong cytoplasmic reactivity for CD22, CD25, CD103, DBA.44, kappa, or lambda light chains. Peripheral blood diagnostic hairy cells were found in all the cases with absolute counts ranging from 0.11 x 10(9)/l up to 6.4 x 10(9)/l and values increasing with the size of the spleen. A median of 36.5% of leukaemic cells was found in bone marrow aspirates and 70% in bone marrow trephine specimens. The monoclonal antibodies CD22 and DBA.44 showed the highest and the lowest percentage of positive hairy cells, respectively; this difference was statistically significant (p = 0.0025). Ultrastructural immunolabelling with DBA.44 showed a cytoplasmic membrane localisation of the antigen in one case of HCL variant. CONCLUSIONS--(1) Immunocytochemistry is a useful technique which enhances the accuracy of diagnosis in HCL; (2) peripheral blood immunocytochemistry is recommended because it highlights hairy cells in all cases; (3) CD22 appears to be the most sensitive of the markers tested; (4) ultrastructural analysis is a useful tool in selected cases of HCL variant.
New Breaker Technology for Fracturing High-Permeability Formations (1995)

Abstract Regained permeability studies with HEC polymer in high-permeability cores revealed that persulfate-type oxidizing breaker and enzyme breaker do not adequately degrade the polymer. Use of high concentrations of acid or peroxide breakers did show improved breaking, but additional work is needed to apply high concentrations of these breakers properly. Sodium persulfate breaker was found to be thermally decomposed, and its decomposition was accelerated by formation minerals. Enzyme breaker adsorbed onto the formation, but still partly functioned as a breaker. Dynamic fluid-loss tests with reduced-pH, borate-crosslinked gels suggest that accelerated leakoff away from the wellbore could be obtained through the use of a delayed-release acid. Rheological measurements confirmed that a soluble delayed-release acid could be used to convert a borate-crosslinked fluid into a linear gel. This conversion was visually confirmed by tests involving a delayed-release acid and a borate-crosslinked fluid in a single-pass flow loop apparatus. Higher concentrations of breaker were placed in a borate-crosslinked fluid by encapsulating the breaker, and controlled viscosity reduction was obtained. A simulation using a 3D commercial simulator showed improved cumulative oil production when increased fluid loss from a soluble delayed-release acid was applied.
Essential amino acid formulations to prevent mitochondrial dysfunction and oxidative stress (2020)

EAA-BCAA balanced supplements might be valuable not only for healthy individuals undergoing to energy deficit (e.g., athletes) during strenuous exercise or training but also against diseases characterized by a dysregulated catabolic state or mitochondrial dysfunction, such as age-related disorders. The associated mechanistic processes should be identified as potential pharmacological targets.
Culture, Constructivism, and Media: Designing a Module on Carlos Slim (2012)

Mexican tycoon Carlos Slim Helú has been a fixture on Forbes’s list of billionaires since 1991, and for the past three years, he has topped the magazine’s list of the world’s richest men. Although he is exceptionally well-known in his native Mexico, the majority of American college students have never heard of Carlos Slim. This article presents a curricular module built around this charismatic and controversial figure. The module requires students to navigate Internet-supported news media in the target language (Spanish), and engages them in independent, small-group, and larger, teacher-led activities designed to foster critical and comparative skills in cultural competency and analysis through process-based, student-led inquiry. Pedagogically and methodologically, the author engages with the recommendations and conclusions of recent studies by ACTFL and MLA committees, as well as by other leading scholars, regarding both the use of technology in the classroom and the idea of “teaching culture.” The unit’s content significantly deepens and enriches students’ understanding of social, economic, and political issues in modern Mexico. The article carefully situates each stage and aspect of the curricular unit presented in relation to recent studies of constructivism in foreign language acquisition and on the hierarchy of Bloom’s taxonomy of learning objectives.
Read‐Out of Single Spins by Optical Spectroscopy (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Gallium-67 as a Tumor-seeking Agent in Lymphomas - a Review (1998)

The sensitivity of gallium scan is very high (80-90%) in the staging and follow-up of Hodgkin's disease, and the method is also of great importance in the follow-up of lymphoma patients. We recommend scintigraphy to study the residual mediastinal mass after treatment. Our experiences during the follow-up of 189 lymphoma patients clearly showed the superior performance of gallium scan compared to MRI in the study of the mediastinal region after treatment. Sensitivity and specificity were both very high (90% and 96.9% vs 88.7% and 89.2%, respectively). Gallium scintigraphy can also be used to study the disease-free interval, post-treatment survival, early signs of recurrence and treatment response times. Comparison of the survival curves of 33 patients with diffuse large cell Non-Hodgkin's lymphoma examined at the National Cancer Institute showed a statistically significant difference (logrank test, P = 0.0125) between patients with positive and those with negative gallium scan after 4-6 cycles of chemotherapy.
Susceptibility of the Porcine Endogenous Retrovirus to Reverse Transcriptase and Protease Inhibitors (2001)

Porcine xenografts may offer a solution to the shortage of human donor allografts. However, all pigs contain the porcine endogenous retrovirus (PERV), raising concerns regarding the transmission of PERV and the possible development of disease in xenotransplant recipients. We evaluated 11 antiretroviral drugs licensed for human immunodeficiency virus type 1 (HIV-1) therapy for their activities against PERV to assess their potential for clinical use. Fifty and 90% inhibitory concentrations (IC(50)s and IC(90)s, respectively) of five nucleoside reverse transcriptase inhibitors (RTIs) were determined enzymatically for PERV and for wild-type (WT) and RTI-resistant HIV-1 reference isolates. In a comparison of IC(50)s, the susceptibilities of PERV RT to lamivudine, stavudine, didanosine, zalcitabine, and zidovudine were reduced >20-fold, 26-fold, 6-fold, 4-fold, and 3-fold, respectively, compared to those of WT HIV-1. PERV was also resistant to nevirapine. Tissue culture-based, single-round infection assays using replication-competent virus confirmed the relative sensitivity of PERV to zidovudine and its resistance to all other RTIs. A Gag polyprotein-processing inhibition assay was developed and used to assess the activities of protease inhibitors against PERV. No inhibition of PERV protease was seen with saquinavir, ritonavir, indinavir, nelfinavir, or amprenavir at concentrations >200-fold the IC(50)s for WT HIV-1. Thus, following screening of many antiretroviral agents, our findings support only the potential clinical use of zidovudine.
Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i> (2003)

Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells. Furthermore, retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+ regulatory T cells. Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells.
Who did What: A Large-Scale Person-Centered Cloze Dataset (2016)

We have constructed a new "Who-did-What" dataset of over 200,000 fill-in-the-gap (cloze) multiple choice reading comprehension problems constructed from the LDC English Gigaword newswire corpus. The WDW dataset has a variety of novel features. First, in contrast with the CNN and Daily Mail datasets (Hermann et al., 2015) we avoid using article summaries for question formation. Instead, each problem is formed from two independent articles --- an article given as the passage to be read and a separate article on the same events used to form the question. Second, we avoid anonymization --- each choice is a person named entity. Third, the problems have been filtered to remove a fraction that are easily solved by simple baselines, while remaining 84% solvable by humans. We report performance benchmarks of standard systems and propose the WDW dataset as a challenge task for the community.
Practical advances in asynchronous design and in asynchronous/synchronous interfaces (1999)

Asynchronous systems are being viewed as an increasingly viable alternative to purely synchronous systems. This paper gives an overview of the current state of the art in practical asynchronous circuit and system design in four areas: controllers, datapaths, processors, and the design of asynchronous/synchronous interfaces.
Visual Tracking With Convolutional Random Vector Functional Link Network (2016)

Deep neural network-based methods have recently achieved excellent performance in visual tracking task. As very few training samples are available in visual tracking task, those approaches rely heavily on extremely large auxiliary dataset such as ImageNet to pretrain the model. In order to address the discrepancy between the source domain (the auxiliary data) and the target domain (the object being tracked), they need to be finetuned during the tracking process. However, those methods suffer from sensitivity to the hyper-parameters such as learning rate, maximum number of epochs, size of mini-batch, and so on. Thus, it is worthy to investigate whether pretraining and fine tuning through conventional back-prop is essential for visual tracking. In this paper, we shed light on this line of research by proposing convolutional random vector functional link (CRVFL) neural network, which can be regarded as a marriage of the convolutional neural network and random vector functional link network, to simplify the visual tracking system. The parameters in the convolutional layer are randomly initialized and kept fixed. Only the parameters in the fully connected layer need to be learned. We further propose an elegant approach to update the tracker. In the widely used visual tracking benchmark, without any auxiliary data, a single CRVFL model achieves 79.0% with a threshold of 20 pixels for the precision plot. Moreover, an ensemble of CRVFL yields comparatively the best result of 86.3%.
Polarization spectroscopy of a closed atomic transition: applications to laser frequency locking (2002)

We study polarization spectroscopy of Rb vapour. A weak probe beam analyses the birefringence induced in a room temperature vapour by a strong counterpropagating circularly polarized pump beam. In contrast to most other work on polarization spectroscopy, we use a polarization beam splitting cube and two detectors (rather than a polarizer and one detector) to analyse the probe beam. The signal is in the form of a derivative of a Lorentzian. For theoretical analysis we study the closed atomic transition 5 2S1/2 (F = 3) --> 5 2P3/2 (F' = 4) in the D2 line of 85Rb. We study the time needed to redistribute population among the mF states, derive an expression for the expected lineshape and present experimental data in excellent agreement with theory. The polarization spectrum provides an ideal error signal for frequency stabilization of a laser. We describe the geometry and parameters for optimizing the error signal.
Feasibility evaluation of reformed methanol usage to spark ignition engine (1987)

To improve the cold starting and low load driveability problem in a methanol fueled car, a reformed methanol fueled si engine with a small methanol reformer using exhaust thermal energy as a heat source was developed and tested. Half of the methanol supplied to the engine was reformed to hydrogen and carbon monoxide, and the rest was supplied in a liquid state. As a result, this engine produces less power than the neat methanol fueled engine. But brake specific fuel consumption of this engine is lower based on the calorific value than that of the neat methanol fueled engine in the wide range of excess air ratio. The co emission levels are not significantly different, whereas the hc emission levels are lower than those from the neat methanol fueled engine. The nox emission levels are higher than those from the neat methanol fueled engine but this problem can be solved by lean burn (a).
Average optimal stationary policies and linear programming in countable space Markov decision processes (2005)

Average optimal stationary policies in countable space Markov decision processes and optimal solutions of an associated infinite dimensional linear program are discussed. Using the theory of linear programming in abstract spaces, sufficient conditions for the existence of optimal solutions are presented, and some previous ones are interpreted.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Interfacial bridge-mediated electron transfer: mechanistic analysis based on electrochemical kinetics and theoretical modelling (2006)

Understanding the physical and chemical factors that control the kinetics of interfacial electron-transfer (ET) reactions is important for a large number of technological applications. The present article describes electrochemical kinetic studies of these factors, in which standard interfacial ET rate constants (k(0)(l)) have been measured for ET between substrate Au electrodes and various redox couples attached to the electrode surfaces by variable lengths (l) of oligomethylene (OM), oligophenylenevinylene (OPV) and oligophenyleneethynylene (OPE) bridges, which were constituents of mixed self-assembled monolayers (SAMs). The k(0)(l) measurements employed the indirect laser-induced temperature jump (ILIT) technique, which permits the measurement of interfacial ET rates that are orders of magnitude faster than those measurable by conventional techniques using the macroelectrodes that are the most convenient substrates for the mixed SAMs. The robustness of the measured rate constants (k(0)(l)), together with the Arrhenius activation energies (E(a)(l)) and preexponential factors (A(l)), is demonstrated by their invariance with respect to several experimental system parameters (including the chemical nature and length of the diluent component of the mixed SAM). Analysis of the kinetic results demonstrates that all of the observed interfacial ET processes proceed through a common type of transition state (predominantly associated with solvent reorganization around the redox moiety) and that the actual ET step involves direct electronic tunnelling between the Au electrode and the redox moiety. However, for the full range of l investigated, a global exponential decay of A(l) is not found for any of the three types of bridges. Possible reasons for this behavior, including the role of rate determining steps associated with adiabatic mechanisms within or beyond the transition state theory framework, are discussed, and comparisons with related conductance measurements are presented.
Fundamental Absorption Edge of SrTi<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (1972)

Detailed measurements of the fundamental absorption edge of SrTi${\mathrm{O}}_{3}$ between 6 and 300 K are reported. Because these results provide the first detailed data below 82 K, several new properties of this material have been observed. The energies of the fundamental transitions are found to have unusually small temperature dependence. It is also observed that the strengths of the phonon-emission and impurity-induced absorption processes are more strongly temperature dependent than is found in other materials. In addition, we propose a different explanation for the prominent shoulder in the absorption at 3.40 eV: that it is merely the saturation of the phonon-assisted transitions.
<i>MAR1</i>—A REGULATOR OF THE <i>HM</i> <b>a</b> AND <i>HMα</i> LOCI IN <i>SACCHAROMYCES CEREVISIAE</i> (1979)

A mutation in the MAR1 (mating-type regulator) locus causing sterility in Saccharomyces cerevisiae is reported. The mutation maps on the left arm of linkage group IV between trp1 and cdc2 at a distance of about 27 cM from trp1 and about 31 cM from cdc2. Haploid strains with genotype MATalpha HMalpha HMa mar1-1 and MATa HMalpha HMamar1-1 are sterile. However, MATalpha hmalpha HMa mar1-1 and MATa HMalpha hma mar1-1 strains exhibit alpha and a mating type, respectively. The sterile strains can be "rare mated" with standard strains as a consequence of mutational changes at HMa and HMalpha. It is proposed that the MAR1 locus blocks the expression of MATalpha and MATa information thought to exist at HMa and HMalpha loci, respectively (Hicks, Strathern and Herskowitz, 1977). In a mar1-1 mutant, the expression of both HMalpha and HMa information leads to a nonmating phenotype similar to that of MATa/MATalpha diploids. The genetic evidence reported here is consistent with a central feature of the "cassette model", namely that HMalpha and hma carry MATa information and HMa and hmalpha carry MATalpha information.
The neural dynamics of updating person impressions (2012)

Person perception is a dynamic, evolving process. Because other people are an endless source of social information, people need to update their impressions of others based upon new information. We devised an fMRI study to identify brain regions involved in updating impressions. Participants saw faces paired with valenced behavioral information and were asked to form impressions of these individuals. Each face was seen five times in a row, each time with a different behavioral description. Critically, for half of the faces the behaviors were evaluatively consistent, while for the other half they were inconsistent. In line with prior work, dorsomedial prefrontal cortex (dmPFC) was associated with forming impressions of individuals based on behavioral information. More importantly, a whole-brain analysis revealed a network of other regions associated with updating impressions of individuals who exhibited evaluatively inconsistent behaviors, including rostrolateral PFC, superior temporal sulcus, right inferior parietal lobule and posterior cingulate cortex.
Tool support for systematic class identification in object-oriented software architectures (2002)

Software architectures have received considerable attention in both research and practice for representing system stakeholder concerns, and many researchers have leveraged object oriented models and methods for software architecture representation and evaluation. While the benefits associated with object oriented approaches are closely aligned with desirable qualities for software architectures (e.g., reusability, extensibility, comprehensibility, performance), these benefits are only realized through rational decision making by the analyst when identifying object oriented classes from a requirements specification. Traditionally, the class identification process has been somewhat subjective, with different analysts often arriving at completely different class models from the same requirements specification. Since this subjectivity does not lend itself to automation, little tool support is available for identifying object oriented classes and their relationships. The paper describes a tool under development, Reference Architecture Representation Environment (RARE), designed to systematically guide the analyst through class identification by applying heuristics associated with quality attributes and evaluating the resulting architecture based on relevant static metrics. RARE helps address a number of challenges typically faced during the class identification process, including: (1) developing an architecture that reflects the quality attributes prioritized by the analyst, (2) managing inherent conflicts between selected attributes, and (3) capturing analyst expertise and rationale for use by others.