gebhart/patrepeval huggingface dataset:
Parking Behavioural and Assignment Modelling: Methodology and application for the evaluation of Smart Parking applications (2014)

Guanine-quadruplexes (G4s) are targets for anticancer therapeutics. In this context, human telomeric DNA (HT-DNA) that can fold into G4s sequences are of particular interest, and their stabilization with small molecules through a visualizable process has become a challenge. As a new type of ligand for HT-G4, we designed a tetraimidazolium tetraphenylethene (<b>TPE-Im</b>) as a water-soluble light-up G4 probe. We study its G4-binding properties with HT-DNA by UV-Visible absorption, circular dichroism and fluorescence spectroscopies, which provide insights into the interactions between <b>TPE-Im</b> and G4-DNA. Remarkably, <b>TPE-Im</b> shows a strong fluorescence enhancement and large shifts upon binding to G4, which is valuable for detecting G4s. The association constants for the <b>TPE-Im</b>/G4 complex were evaluated in different solution conditions via isothermal titration calorimetry (ITC), and its binding modes were explored by molecular modeling showing a groove-binding mechanism. The stabilization of G4 by <b>TPE-Im</b> has been assessed by Fluorescence Resonance Energy Transfer (FRET) melting assays, which show a strong stabilization (Δ<i>T</i> <sub>1/2</sub> around +20°C), together with a specificity toward G4 with respect to double-stranded DNA.
Aspirin, NSAIDs, and Risk Reduction of Colorectal Cancer (1994)

CANCERS OF the colon and rectum cumulatively account for approximately 15% of all visceral tumors, affecting about one person in 20 in the United States and most other Western countries. Rapid advances in molecular biology may soon allow for genetic screening of individuals at risk for the development of colorectal cancer. The gene for familial adenomatous polyposis has been cloned and sequenced, and recently the gene coding for hereditary nonpolyposis colorectal cancer has been mapped to a locus on chromosome 2.<sup>1</sup>Familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer may account for as much as 5% to 14% of all colorectal cancer in industrialized nations, but men and women over the age of 40 years still constitute the the largest population at risk. During the last several decades, the incidence of these cancers has remained relatively constant, although there has been a progressive trend toward disease of the more
Purification, characterization, and localization of a protein antigen shared by thermophilic campylobacters (1990)

A protein antigen with an apparent molecular weight (Mr) of 31,000 was isolated from 0.2 M glycine hydrochloride (pH 2.2) extracts of a typical human fecal isolate, Campylobacter jejuni VC74. The protein was purified to homogeneity on a preparative scale by immunoaffinity chromatography followed by molecular sieving with a Superose 12 column. Isoelectric focusing under nondenaturing conditions indicated a pI of 9.3, and amino acid composition analysis showed that the protein was unusually rich in lysine, containing 14.9 mol% of this basic amino acid. Cysteine and tryptophan were absent. The protein also contained approximately 35% hydrophobic amino acid residues, and N-terminal amino acid analysis showed that 17 of the first 38 residues were hydrophobic. This amino-terminal sequence to residue 22 was virtually identical to that of an antigenically cross-reactive 31,000-Mr protein isolated from another C. jejuni strain belonging to a different heat-labile serogroup. Western blotting (immunoblotting) of glycine extracts of other C. jejuni, Campylobacter coli, and Campylobacter laridis strains belonging to different thermolabile and thermostable serotypes, as well as Campylobacter fetus, with a rabbit polyclonal antiserum raised against the purified C. jejuni VC74 protein showed that all C. jejuni, C. coli, and C. laridis strains tested contained a 31,000-Mr protein with epitopes which were antigenically cross-reactive with the C. jejuni VC74 protein. The antigenically cross-reactive epitopes of this protein were also readily detected by immunodot blot assay of glycine extracts of C. jejuni, C. coli, and C. laridis with monospecific polyclonal antisera to the 31,000-Mr protein, suggesting that this serological test could be a useful addition to those currently employed in the rapid identification of these important pathogens. Slide agglutination reactions, immunofluorescence assay, and immunogold electron microscopy with antisera to purified 31,000-Mr protein and trypsin treatment of whole cells indicated that the cross-reactive epitopes of the 31,000-Mr protein were not exposed on the cell surface. Cell fractionation analysis and immunogold electron microscopy located the protein on the outer surface of the cytoplasmic membrane. This finding suggests that the 31,000-Mr protein is not a good candidate for inclusion in a monovalent subunit Campylobacter vaccine.
Equivalent circuit of a dipole antenna using frequency-independent lumped elements (1993)

A four-element lumped-parameter equivalent circuit, consisting of a resistance, an inductance, and two capacitances, has been found to represent the feed-point impedance of a dipole antenna. The values of these elements are related only to the physical dimensions of the antenna, not the frequency of operation. Empirical formulas are given for all the elements. The equivalent circuit gives negligible errors in radiation resistance and reactance for dipole half-lengths less than 0.1 lambda , rising to 1% for resistance and 6% for reactance at 0.25 lambda . It can be readily used in standard computer software packages such as SPICE, PSPICE, and MICROCAP.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Phosphine Exposure from a Methamphetamine Laboratory Investigation (2001)

This is apparently the first published case of symptomatic occupational phosphine exposure in a law enforcement officer during investigation of a methamphetamine laboratory. If phosphine exposure is suspected, the possibility of delayed pulmonary toxicity should be recognized.
OBSERVATIONS ON THE ROD AND CONE LAYER OF THE HUMAN RETINA. A LIGHT AND ELECTRON MICROSCOPIC STUDY. (1963)

Electron microscopy combined with certain histochemical studies on thin sections of the human retina has provided additional information concerning the mucinous material that occupies the intercellular space between the outer limiting membrane and the retinal pigment epithelium. The myoid region of the inner segments of hotli rods and cones contains an abundance of organelles associated with the intmcellular elaboration of mucinous and proteinaceous substances. It is suggested that this part of the photoreceptor cells is the most likely source of the mucoid ground substance in which the inner and outer segments of the visual cells are suspended. The organelles that are so concentrated in the apical region of the photoreceptor cells are probably also involved in the production of intracellular materials required for photoreception and/or generation and transmission of nerve impulses.
Hierarchical Topic Models and the Nested Chinese Restaurant Process (2003)

We address the problem of learning topic hierarchies from data. The model selection problem in this domain is daunting—which of the large collection of possible trees to use? We take a Bayesian approach, generating an appropriate prior via a distribution on partitions that we refer to as the nested Chinese restaurant process. This nonparametric prior allows arbitrarily large branching factors and readily accommodates growing data collections. We build a hierarchical topic model by combining this prior with a likelihood that is based on a hierarchical variant of latent Dirichlet allocation. We illustrate our approach on simulated data and with an application to the modeling of NIPS abstracts.
The Modified Gouy-Chapman Theory: Comparisons between Electrical Double Layer Models of Clay Swelling (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Modified Gouy-Chapman Theory: Comparisons between Electrical Double Layer Models of Clay SwellingJeffery A. Greathouse, Scott E. Feller, and Donald A. McQuarrieCite this: Langmuir 1994, 10, 7, 2125–2130Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/la00019a018https://doi.org/10.1021/la00019a018research-articleACS PublicationsRequest reuse permissionsArticle Views1107Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Distinct effects of losartan and atenolol on vascular stiffness in Marfan syndrome (2015)

We conducted a randomized, double-blind trial of losartan (100 mg QD) versus atenolol (50 mg QD) for 6 months in adults with Marfan syndrome. Carotid-femoral pulse wave velocity (PWV), central augmentation index (AIx), aortic diameter and left ventricular (LV) function were assessed with arterial tonometry and echocardiography. Thirty-four subjects (18 female; median age 35 years, IQR 27, 45) were randomized. Central systolic and diastolic blood pressure decreased comparably with atenolol and losartan (p = 0.64 and 0.31, respectively); heart rate decreased with atenolol (p = 0.02), but not with losartan. PWV decreased in patients treated with atenolol (-1.15 ± 1.68 m/s; p = 0.01), but not in those treated with losartan (-0.22 ± 0.59 m/s; p = 0.15; between-group difference p = 0.04). In contrast, AIx decreased in the losartan group (-9.6 ± 8.6%; p < 0.001) but not in the atenolol group (0.9 ± 6.2%, p = 0.57; between-group difference p < 0.001). There was no significant change in aortic diameters or LV ejection fraction in either treatment group. In adults with Marfan syndrome, 6 months of treatment with atenolol improves PWV, whereas losartan reduces the AIx. By improving vascular stiffness via distinct mechanisms of action, there is physiologic value to considering the use of both medications in individuals with Marfan syndrome.
Debittering Mechanism in Bitter Peptides of Enzymatic Hydrolysates from Milk Casein by Aminopeptidase T (1989)

ABSTRACT The bitter peptide fraction present in casein hydrolysates obtained by using three proteases (subtilisin, papain and trypsin) was treated with aminopeptidase T from Thermus aquaticus YT‐1. The bitterness of the bitter peptide fraction could be decreased, and it sometimes disappeared completely, with an increase in free amino acids. The percentages of total free amino acids released from each bitter peptide fraction (subtilisin, papain and trypsin) by aminopeptidase digestion for 20 hr were approximately 11%, 8.7%, and 6.5%, respectively. Bitter peptide (α s 1‐CN f91‐100) was isolated from a tryptic hydrolysate of casein by HPLC, its threshold value of bitterness being 2.9 ppm (w/v). The peptide (α s 1‐CN f96‐100) obtained from the amino peptidase digestion of this bitter peptide showed no bitterness.
Effect of Ag Templates on the Formation of Au-Ag Hollow/Core-Shell Nanostructures (2015)

Au-Ag alloy nanostructures with various shapes were synthesized using a successive reduction method in this study. By means of galvanic replacement, twined Ag nanoparticles (NPs) and single-crystalline Ag nanowires (NWs) were adopted as templates, respectively, and alloyed with the same amount of Au(+) ions. High angle annular dark field-scanning TEM (HAADF-STEM) images observed from different rotation angles confirm that Ag NPs turned into AuAg alloy rings with an Au/Ag ratio of 1. The shifts of surface plasmon resonance and chemical composition reveal the evolution of the alloy ring formation. On the other hand, single-crystalline Ag NWs became Ag@AuAg core-shell wires instead of hollow nanostructure through a process of galvanic replacement. It is proposed that in addition to the ratio of Ag templates and Au ion additives, the twin boundaries of the Ag templates were the dominating factor causing hollow alloy nanostructures.
Self-contained automatic recorder of the dc Josephson current (1978)

A circuit for the automatic recording of the dc Josephson current as a function of magnetic field or other variable has been designed and constructed. The apparatus requires no additional signal processing devices as have techniques for this measurement utilized in the past. Sensitivity to critical current amplitudes corresponding to the appearance of 5 mV across a sensing resistor is attained, as well as separate examination of the positive and negative halves of the zero-bias current.
Computational out-of-focus imaging increases the space–bandwidth product in lens-based coherent microscopy (2016)

The space–bandwidth product (SBP) of modern objective lenses is often significantly larger than the pixel count of opto-electronic image sensor chips, and, therefore, much of the information transmitted by the optical system cannot be adequately sampled or digitized. To resolve this mismatch, microscopes are in general designed to maintain the resolution of the optical system while significantly wasting the field of view (FOV) and SBP of the objective lens. We introduce a wide-field and high-resolution coherent imaging method that uses a stack of out-of-focus images to provide much better utilization of the SBP of an objective lens. We demonstrate our approach on a benchtop microscope by using a demagnification camera adapter to match the active area of the image sensor chip to the FOV of an objective lens. We show that the resulting spatial undersampling caused by capturing a large FOV can be mitigated through an iterative pixel super-resolution algorithm that uses e.g., ∼three to five slightly out-of-focus images, yielding an ∼8-fold increase in the SBP of the microscope. Furthermore, the same pixel super-resolution algorithm also achieves phase retrieval, revealing the optical phase information of the specimen. We compared our method against traditional off-axis and phase-shifting digital holographic microscopy modalities and demonstrated at least 3-fold reduction in the number of images required to achieve the same SBP. This technique could be used to maximize the throughput and SBP of lens-based coherent imaging and holography systems and inspire new microscopy designs that benefit from the inherent autofocusing steps of a scanning microscope to increase its SBP.
In vitro Assay of Cell-Free Turkey Herpesvirus (1972)

SUMMARY The susceptibility of cultures of chicken cells to cell-free turkey herpesvirus (HVT) was affected by the age of the culture but not by cell type, cell passage, or age and genetic constitution of the donor. Chicken embryo fibroblasts (CEF), chicken kidney (CK), and chicken embryo kidney cells all were of equal sensitivity, but duck embryo fibroblasts were only one-fourth as susceptible as the chicken cells. Three- or 24-hour CEF and 24-hour CK cell monolayers were more sensitive than 48- or 72-hour cultures. CEF cells inoculated while in suspension were less sensitive than those inoculated as monolayer cultures. About 7.5 X 106 CEF seeded per 60mm Petri dish was found optimal. The type and pH of the virus diluent and the presence or absence of a chelator in the inoculum were without effect on virus titer, but a stabilizer containing sucrose and bovine albumin (SPA) rendered the virus less thermolabile and less susceptible to freezethaw cycles. Mechanical treatments of the inoculum, such as vigorous pipetting or sonic vibration, increased virus titers, apparently by causing better virus dispersion.
Radiation Resulting from Recombination of Holes and Electrons in Silicon (1956)

Radiation produced by the recombination of excess electrons and holes in silicon has been examined both at room temperature and at 77\ifmmode^\circ\else\textdegree\fi{}K. The radiation obtained at room temperature is shown to be an intrinsic property of silicon. It is probably due to indirect transitions of electrons from the conduction band minima to the valence band with phonon cooperation. Additional radiation is found at 77\ifmmode^\circ\else\textdegree\fi{}K which is structure-sensitive. This radiation is shown to be produced by the recombination of excess carriers with unionized donor and acceptor impurities. Differences between the photon energies associated with the maximum photon emission of intrinsic and extrinsic radiation are in semiquantitative accord with accepted values of ionization energies of the donor and acceptor impurities introduced in the crystal-growing process.
Isolation of an IgG anti‐B from a human Fab‐phage display library (2001)

FB5.7 is the first human IgG ABO MoAb described. Alhough it behaves serologically like a group B-specific antibody, it demonstrates interaction with both the A and B epitopes. Phage-display technology can be used to better define the relationship between antibody genotype and phenotype in anti-carbohydrate responses in nonhyperimmunized hosts, and thus to improve our understanding of the composition of the antibody repertoire.
Relationship between dietary fat and experimental mammary tumorigenesis: a review and critique. (1992)

That dietary fat can significantly affect mammary tumorigenesis in mice and rats has been clearly established. The purpose of this communication is to review and critique this interesting and potentially important relationship. This review focuses on the relationship between the amount and type of dietary fat and the role of calories in rodent mammary tumor development and metastasis. Additionally, the influence of dietary fat on development of human breast carcinoma transplants in immunodeficient mice is examined. The numerous studies cited in this review provide a compelling biological foundation for a potentially important relationship between dietary fat and/or calorie consumption and breast carcinoma development in human populations.
Inductance measurements of superconducting chip-to-package connectors suitable for Josephson LSI technology (1979)

It is necessary in any interconnection scheme used in LSI to be able to pass high-speed pulses from chip-to-chip through the package with a minimum of distortion while at the same time maximizing the number of input/output connectors (I/O's) in large arrays of densely packed connectors. We have measured the inductances (both self and mutual) of chip-to-package connectors which were arranged in a peripheral row around the edge of the circuit chip. The largest self-inductance measured for an 8:1 ratio of I/O's to ground connectors is low enough so that signals with a 30 ps time constant propagate through the connector without significant distortion. The largest self-inductance ranges from 28 pH for the linear array of eight connectors between grounds to 19 pH for four connectors between grounds. These results indicate that the electrical properties of these connectors are satisfactory for the LSI technology application of Josephson devices.
Students’ Motivational Orientations and Attitude toward English Learning: A Study in the Deep South of Thailand (2014)

This study investigates students’ L2 motivational orientations and attitude which are major components of L2 motivation. The concepts of integrative and instrumental orientations and attitude in this study were adopted and adapted from Gardner’s socio-educational model (1985). 219 M.3 (Grade 9) students in all six governmental secondary schools in the three southernmost cities in Thailand, namely Pattani, Yala, and Narathiwas participated in this study. The questionnaire with 10 items assessing the students’ integrative and instrumental orientations and attitude was the main instrument. The results indicate that the students have strong instrumental orientation together with moderately high integrative orientation and favorable attitude. All three motivational components were found significantly different between the male and female students. In regard to the difference between the students with and without experience in English speaking countries, significant difference was on integrative orientation. Last, there was no significant difference on integrative and instrumental orientations and attitude between the students with the above and below average English grade.
RSeQC: quality control of RNA-seq experiments (2012)

RSeQC is written in Python and C. Source code and a comprehensive user's manual are freely available at: http://code.google.com/p/rseqc/.
Overcharging by macroions: above all, an entropy effect (2001)

Model macroion solutions next to a charged wall show interface \textit{true overcharging}, charge reversal and inversion, and layering. Macroion layering is present, even if the wall or the macroparticle are \textit{uncharged} or if the wall and macroions are like-charged. An effective long-range attractive force between the adsorbed macroions is implied. The results are obtained through an integral equation theory and a new extended Poisson-Boltzmann theory, and are in accordance with experiments on confined macroions and polymer layering.
Light Reflectance Compared with Other Nitrogen Stress Measurements in Corn Leaves (1994)

Abstract New tools that can rapidly quantify the N status of corn could be valuable in N fertilizer management practices. This study was conducted to compare light reflectance from corn leaves with other parameters used to detect N deficiencies. Light reflectance (400–700 nm) as measured from corn leaves in the laboratory with a Hunter tristimulus colorimeter was compared with Minolta SPAD 502 chlorophyll meter readings (light transmittance at 650 and 940 nm), leaf N concentrations, and specific leaf N (N content per unit area). Measurements were made on individual ear leaves collected from an irrigated corn N response trial with four hybrids and five N treatments. Light reflectance near 550 nm was the best wavelength to separate N treatment differences. Reflectance at 550 nm provided a stronger relationship with both leaf N concentration and chlorophyll meter readings than between chlorophyll meter readings and leaf N concentration. The measurement of light reflectance near 550 nm has promise as a technique to detect N deficiencies in corn leaves.