gebhart/patrepeval huggingface dataset:
Keap1 Controls Postinduction Repression of the Nrf2-Mediated Antioxidant Response by Escorting Nuclear Export of Nrf2 (2007)

The transcription factor Nrf2 regulates cellular redox homeostasis. Under basal conditions, Keap1 recruits Nrf2 into the Cul3-containing E3 ubiquitin ligase complex for ubiquitin conjugation and subsequent proteasomal degradation. Oxidative stress triggers activation of Nrf2 through inhibition of E3 ubiquitin ligase activity, resulting in increased levels of Nrf2 and transcriptional activation of Nrf2-dependent genes. In this study, we identify Keap1 as a key postinduction repressor of Nrf2 and demonstrate that a nuclear export sequence (NES) in Keap1 is required for termination of Nrf2-antioxidant response element (ARE) signaling by escorting nuclear export of Nrf2. We provide evidence that ubiquitination of Nrf2 is carried out in the cytosol. Furthermore, we show that Keap1 nuclear translocation is independent of Nrf2 and the Nrf2-Keap1 complex does not bind the ARE. Collectively, our results suggest the following mechanism of postinduction repression: upon recovery of cellular redox homeostasis, Keap1 translocates into the nucleus to dissociate Nrf2 from the ARE. The Nrf2-Keap1 complex is then transported out of the nucleus by the NES in Keap1. Once in the cytoplasm, the Keap1-Nrf2 complex associates with the E3 ubiquitin ligase, resulting in degradation of Nrf2 and termination of the Nrf2 signaling pathway. Hence, postinduction repression of the Nrf2-mediated antioxidant response is controlled by the nuclear export function of Keap1 in alliance with the cytoplasmic ubiquitination and degradation machinery.
Inhibition of Dipeptidyl Peptidase iv (CD26) by Peptide Boronic Acid Dipeptides (1997)

Peptide boronic acid dipeptide compounds were analyzed for their ability to inhibit recombinant human dipeptidylpeptidase IV (CD26, DPPIV). Rate constants for the peptide boronates are difficult to obtain because the active boronic acid dipeptide exists in equilibrium with a cyclic inactive species in aqueous solution. Rate constants were determined for the inhibition of DPPIV using several peptide boronates at different pH values. Val-boroPro forms the most tightly bound complex with DPPIV; the first order half life for dissociation of the inactive enzyme-inhibitor complex at 23 degrees C is approximately 27 days.
Predicting Tensile and Compressive Moduli of Structural Lumber (2011)

Nondestructive bending modulus of elasticity (MOE) of lumber is commonly used as input data to estimate mechanical properties of glued lumber or laminated timber components.Many standard and nonstandard test methods exist to determine MOE.However, when glued components are loaded, the stresses imposed on the lumber subcomponents are quite different from stresses used in determining MOE of the lumber.It is well known that the bending MOE of lumber is somewhat different from its tensile and compressive moduli.Therefore, defining the differences and relationships between bending MOE and tensile and compressive moduli is important.This study predicted the tensile and compressive modulus from dynamic and static bending MOE of major softwood structural lumber in Korea.The measured MOE and tensile and compressive moduli from the same specimens by various test methods were found to differ.In particular, the tensile modulus was twice the compressive modulus for the same specimen.Edgewise bending MOE, which showed the highest correlation with tensile and compressive moduli, was suggested as a suitable input parameter for predicting tensile and compressive moduli.Predicting tensile and compressive moduli from dynamic or flatwise bending MOE of structural lumber is also possible, although with a different relationship.With better prediction of tensile and compression moduli, it is expected that the properties of engineered wood or timber structures can be more accurately estimated.
Study of increasing spore content of Beauveria bassiana (2001)

Adding some protein of Antheraa pernyi pupae as the replacement of powder of bean cake and meize flour into Beauveria bassiana raw material and culturing solid in three degrees in iron plate can significantly increase the spores content of Beauveria bassiana, reduce the cost and raise and effect.
Molecular Epidemiologic Approaches to Urinary Tract Infection Gene Discovery in Uropathogenic <i>Escherichia coli</i> (2000)

Urinary tract infection (UTI) is one of the most frequently acquired bacterial infections. The vast majority of UTIs are caused by a large, genetically heterogeneous group of Escherichia coli. This genetic diversity has hampered identification of UTI-related genes. A three-step experimental strategy was used to identify genes potentially involved in E. coli UTI transmission or virulence: epidemiologic pairing of a UTI-specific strain with a fecal control, differential cloning to isolated UTI strain-specific DNA, and epidemiologic screening to identify sequences among isolated DNAs that are associated with UTI. The 37 DNA sequences initially isolated were physically located all over the tester strain genome. Only two hybridized to the total DNA of the sequenced E. coli K-12 strain; eight sequences were present significantly more frequently in UTI isolates than in fecal isolates. Three of the eight sequences matched to genes for multidrug efflux proteins, usher proteins, and pathogenicity island insertion sites, respectively. Using population characteristics to direct gene discovery and evaluation is a productive strategy applicable to any system.
Development of Model-Based OBDII-Compliant Evaporative Emissions Leak Detection Systems (2008)

<div class="htmlview paragraph">The paper presents the main results obtained by developing and critically comparing different evaporative emissions leak detection diagnostic systems.</div> <div class="htmlview paragraph">Three different leak detection methods have been analyzed and developed by using a model-based approach: depressurization, air and fuel vapor compression, and natural vacuum pressure evolution. The methods have been developed to comply with the latest OBD II requirement for 0.5 mm leak detection. Detailed grey-box models of both the system (fuel tank, connecting pipes, canister module, engine intake system) and the components needed to perform the diagnostic test (air compressor or vacuum pump) have been used to analyze in a simulation environment the critical aspects of each of the three methods, and to develop “optimal” diagnostic model-based algorithms. Experiments have been initially carried out in a laboratory environment to identify both the main model unknown parameters and the main disturbances, and to acquire data that could be used to validate the simulation results. During a subsequent phase of the project, a prototype vehicle has been setup with various sensors and actuators, and several experiments have been conducted to test the three leak detection model-based methods, while varying environmental and in-vehicle conditions. The critical aspects of each methodology have thus been isolated and compared, also by taking into account actual and possibly future European and North American on-board diagnostic regulations.</div>
Das Holzscheit (1970)

Ich hatte meine Pantoffeln angezogen und war in meinen Schlafrock geschlüpft. Dann wischte ich eine Träne ab, die der scharfe Wind auf dem Quai mir ins Auge getrieben hatte und die meinen Blick trübte. Im Kamin meines Arbeitszimmers flackerte ein helles Feuer. Eisblumen in Gestalt von Farnwedeln blühten an den Fensterscheiben und entzogen mir den Blick auf die Seine mit ihren Brücken und auf den Louvre der Valois.
Retinoid X receptor-alpha and apolipoprotein AI regulatory protein 1 differentially modulate 3,5,3'-triiodothyronine-induced transcription (1995)

The formation of heterodimers with thyroid hormone receptor (TR) and other nuclear hormone receptors on thyroid hormone response elements (TREs) is important for T3-regulated gene transcription. The potential roles of retinoid X receptor-alpha (RXR alpha) and apolipoprotein regulatory protein-1 (ARP-1) in T3-mediated transcription were studied on a well characterized TRE, a direct repeat of AGGTCA separated by four nucleotides (DR4), using electrophoretic mobility shift assays and transient transfection in CV-1 cells. It was shown that RXR alpha blocked liganded TR alpha-induced transcription. However, ARP-1 did not block T3/TR alpha-mediated transcription, although both TR alpha/RXR alpha and TR alpha/ARP-1 heterodimers had similar affinities for the TRE-DR4. In contrast, wild type ARP-1 reversed the blocking effect of RXR alpha on the liganded TR alpha-induced transcription, whereas a dimerization domain-deleted ARP-1 mutant (ARP-1 delta C) did not, suggesting that ARP-1 modulates T3-induced transcription through a dimerization process. Thus, the TRE-DR4 differentially responds to T3 at the transcriptional level by accommodating a battery of TR heterodimeric complexes.
<title>Automated detection of midsagittal plane in MR images of the head</title> (2001)

A fully automated and robust method is presented for dividing MR 3D images of the human brain into two hemispheres. The method is developed specifically to deal with pathologically affected brains or brains in which the longitudinal fissure (LF) is significantly widened due to ageing or atrophy associated with neuro-degenerative processes. To provide a definitive estimate of the mid- sagittal plane, the method combines longitudinal fissure lines detected in both axial and corona slices of T1- weighted MR images and then fit these lines to a 3D plane. The method was applied to 36 brain MR image data sets (15 of them arising from subjects with probable Alzheimer's disease) all exhibiting some degrees of widened fissures and/or significant asymmetry due to pathology. Visual inspection of the results revealed that the separation was highly accurate and satisfactory. In some cases (5 in total), there were minor degrees of asymmetry in the posterior fossa structures despite successful splitting of cerebral cortex.
EVALUATION OF ANTIDIABETIC POTENTIAL OF NYMPHAEA NOUCHALI BURM. F. SEEDS IN STZ - INDUCED DIABETIC RATS (2014)

Objective: The aim of the present study was to investigate the antihyperglycaemic activity of hydroalcohol extract of Nymphaea nouchali seeds (NN) in streptozotocin (STZ) – induced diabetic rats. Methods : Acute oral toxicity study was carried out in normal female rats. Male sprague dawley rats were rendered diabetic by STZ (50 mg/kg b.wt. i.p.). At a dose of 100 and 200 mg/kg of body weight, NN extract was administered orally to diabetic rats for 21 days. Metformin was used as a standard drug at a dose of 250 mg/kg b.wt. The antihyperglycaemic activity was determined by estimating various biochemical parameters. Results : Oral administration of NN extract showed significant restoration of blood glucose level to normal. After 21 days of treatment, level of blood glucose, lipid profile (total cholesterol, triglyceride), hepatic and renal markers (SGOT, SGPT, γGT, ALP, bilirubin, creatinine and BUN) significantly decreased when compared with the diabetic control. Concurrent histopathological studies of the heart and liver revealed normal histological pattern in the normal and extract-treated groups. Conclusion: Lowering of blood glucose and other associated markers suggest that NN extract possess potent antidiabetic acitivty and hence confirms the traditional usage of this plant in the management of diabetes. However, histopathological examination of the pancreas suggests that this activity is brought by extrapancreatic mechanisms. Further, the exact mechanism of its action is yet to be elucidated.
Know your enemy (2013)

Smartphones store large amounts of sensitive data, such as SMS messages, photos, or email. In this paper, we report the results of a study investigating users' concerns about unauthorized data access on their smartphones (22 interviewed and 724 surveyed subjects). We found that users are generally concerned about insiders (e.g., friends) accessing their data on smartphones. Furthermore, we present the first evidence that the insider threat is a real problem impacting smartphone users. In particular, 12% of subjects reported a negative experience with unauthorized access. We also found that younger users are at higher risk of experiencing unauthorized access. Based on our results, we propose a stronger adversarial model that incorporates the insider threat. To better reflect users' concerns and risks, a stronger adversarial model must be considered during the design and evaluation of data protection systems and authentication methods for smartphones.
Spring, 1930 catalog / (1930)

LILIUM HARRISI (F.O.B. New York only
Symbolic generation of constrained random logic cells (1991)

A symbolic cell generator (SYC) that can generate the symbolic layout of a generic CMOS logic cell is presented. It accepts as input a SPICE-like netlist describing circuit components, connectivity, and the list of the I/O pins. Using this generator, the user can specify topological constraints on pin and transistor positions, the maximum lengths of polysilicon and diffusion wires, and a preferred layer for each electrical node. Cells are generated according to optimization criteria that take into account not only geometric factors, such as cell area, aspect ratio, and wirelength, but also electrical features, namely capacitance to the substrate and contact and via minimization. The generator's placement strategy includes transistor clustering into regions, global region placement by linear ordering, and two-dimensional local transistor placement. The routing combines Steiner trees and Lee algorithms. Object-oriented programming paradigms were used in the implementation of the program, written in C++ language. Experimental results for small and medium-sized cells are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Lactobacillus acetotolerans, a New Species from Fermented Vinegar Broth (1986)

Thirteen strains of rod-shaped lactic acid bacteria, resistant to high concentrations of acetic acid, were isolated from the fermented broth of rice vinegar. These isolates showed homofermentation and differed from all the validly described homofermentative species of the genus Lactobacillus. Although the isolates were divided into two groups on the basis of acid production pattern from carbohydrates and nutritional requirements for growth, all showed extremely high deoxyribonucleic acid homology. The isolates were considered to represent a new species of the genus Lactobacillus. The two groups, based on their biochemical and physiological properties, were treated as biovar I and biovar II. A new species proposed for these isolates was named Lactobacillus acetotolerans. The type strain of L. acetotolerans sp. nov. is NBI3014 (=JCM 3825).
Globus pallidus internus pallidotomy for generalized dystonia (1997)

The authors present a young boy with severe generalized dystonia treated with bilateral simultaneous pallidotomy. Microelectrode recordings with the patient under propofol anesthesia showed that the mean discharge rate of globus pallidus internus (GPi) neurons was between 21 and 31 Hz. This contrasts sharply with the mean GPi neuronal firing rates of approximately 80 Hz that are characteristic of Parkinson's disease. The patient had no immediate benefit from surgery, but a progressive improvement in both axial and limb dystonia began within 3 days. The Burke-Fahn-Marsden scores were 75 (maximum possible = 120) at baseline, 52 at 5 days, and 16 at 3 months after surgery. The mechanism of action of pallidotomy for dystonia and the reasons for the delayed and progressive improvement are unknown. Nevertheless, the magnitude of the improvement and the safety of the procedure in this one patient warrant a careful evaluation of pallidotomy for dystonia.
Joint Analysis of Time-Evolving Binary Matrices and Associated Documents (2010)

We consider problems for which one has incomplete binary matrices that evolve with time (e.g., the votes of legislators on particular legislation, with each year characterized by a different such matrix). An objective of such analysis is to infer structure and inter-relationships underlying the matrices, here defined by latent features associated with each axis of the matrix. In addition, it is assumed that documents are available for the entities associated with at least one of the matrix axes. By jointly analyzing the matrices and documents, one may be used to inform the other within the analysis, and the model offers the opportunity to predict matrix values (e.g., votes) based only on an associated document (e.g., legislation). The research presented here merges two areas of machine-learning that have previously been investigated separately: incomplete-matrix analysis and topic modeling. The analysis is performed from a Bayesian perspective, with efficient inference constituted via Gibbs sampling. The framework is demonstrated by considering all voting data and available documents (legislation) during the 220-year lifetime of the United States Senate and House of Representatives. 1
Challenges in demand load control for the smart grid (2011)

The ground to address challenges in demand load control for the smart power grid is now more fertile than ever, due to advances in communication infrastructures and the creation of a two-way channel for real-time communication between consumers and the utility operator. After giving a taxonomy of methods for demand load control, we focus on two of these methods that aim at minimizing the grid operational cost. The cost is a convex function of instantaneous power consumption and reflects the fact that each additional unit of power needed to serve demands is more expensive as the demand load increases. First, we consider online scheduling of power demand tasks that have time flexibility in being activated, in terms of a deadline. We outline the rationale for threshold-based policies that activate a demand if the instantaneous consumption is low; otherwise, they postpone it until later. Second, we discuss the use of stored energy for serving part of the demand at peak load times. This implies increasing the demand load at off-peak times through battery charging and decreasing the demand load at peak load times through discharging. We conclude with some open challenges in demand load management.
Determination of Arginine in the Reactive Site of Proteinase Inhibitors by Selective and Reversible Derivatization of the Arginine Side Chain (1976)

Reversible and selective modification of the guanidino group by 1,2-cyclohexanedione or 2,3-butanedione in borate buffer was applied to identify arginine residues in the reactive sites of proteinase inhibitors. The ability of the method to distinguish between arginine and lysine residues was examined. Trypsin inhibitors with arginine at the reactive site were almost completely inactivated within 2 h, e.g. the low-molecular weight inhibitors from soybeans (Kunitz), peanuts and porcine seminal plasma. Inhibitors of the lysine-type were not inactivated by 1,2-cyclohexanedione/borate, e.g. the bovine trypsin/kallikrein inhibitor, the trypsin inhibitors from cow colostrum, porcine pancreas, or snail epidermis (isoinhibitor K from Helix pomatia), and the human alpha1-proteinase inhibitor (alpha1-antitrypsin). However, 2,3-butanedione/borate does not show this high specificity. The method was applied to four high-molecular weight proteinase inhibitors from the albumin gland of the snail (Helix pomatia). All four inhibitors were subject to inactivation by the reagent, indicating an arginine residue at the reactive site. Evidence is given by NMR, UV, and titration data that a complex is formed from 1,2-cyclohexanedione and borate. Due to this complex formation, the amount of free carbonyl component is drastically decreased. Since 1,2-cyclohexanedione without borate lacks the high specificity for arginine residues, the borate complex of the reagent is presumed to be responsible for the high specificity. The new procedure for identification of reactive sites is based on a reversible modification of the guanidium group of the arginine residues.
An IMS-based testbed for real-time services integration and orchestration (2009)

In this paper, we introduce an IP multimedia sub-system (IMS) based testbed which provides a platform for the study of real-time services integration and orchestration. This open-source based testbed is built on the principle of service oriented architecture (SOA), with an emphasis for real-time network services. We further developed service-oriented system functionalities such as optical network connection and bandwidth management, mobile client authentication protocols, and video streaming services. They are packaged as interoperable service components, so that they can be integrated and orchestrated through their respective standard interfaces. Finally, we elaborated our proof-of-concept environment via a use-case scenario of having various client-server interactions over a heterogeneous network environment.
Hologram Optimisation Using Liquid Crystal Modelling (2005)

ABSTRACT Beam steering liquid crystal devices employed in telecommunication networks suffer from high crosstalk. This is due to the limited resolution arising from the finite extent of the liquid crystal elastic deformation and the electric field fringing. In this paper we show how non-periodic phase elements (holograms) can reduce crosstalk. A new model is devised to evaluate the approximate liquid crystal phase profile that is many times faster than the finite element method, enabling its evaluation millions of times as it is required by the hologram iterative design algorithms. Holograms designed using the new model had improved performance and flexibility compared to periodic gratings.