gebhart/patrepeval huggingface dataset:
Vitamin D, Glutamine, Evidence-Based Medicine, and Close Staff Supervision Reduce Mortality Rate at a Level I Trauma Center (2017)

Background: It has been estimated that over 400,000 patients die each year from medical errors in the United States. The purpose of this study was to investigate the impact of vitamin D (a steroid hormone and immune modulator) and glutamine supplementation, evidence- based medicine, and close staff supervision on hospital mortality rate in trauma patients. We hypothesized that vitamin D and glutamine supplementation, evidence-based medicine, and close staff supervision has an appreciable or measureable effect in reducing the hospital mortality rate in critically injured patients admitted to surgical intensive care units and to surgical floors. Study Design: We performed a retrospective study of 6,258 trauma patients listed in the trauma registry who were admitted to the Trauma Service at Grady Memorial Hospital, a Level I trauma center, between January 1, 2000 and December 31, 2011. The analysis compared two groups: standard care treatment group (Control Group)) versus the evidence-based medicine treatment group (Evidence -Based Medicine Group). Trauma patients admitted from 2000-2006 (Control Group, n=3,285) were treated with standard (usual) care. Trauma patients admitted from 2007-2011 (Evidence-Based Medicine Group, n=2,973) were managed with standard care plus vitamin D and glutamine supplementation, evidence –based medicine, and close staff supervision. The primary outcome was mortality rate of the Control Group versus the Evidence-Based Medicine Group. Results: Our study did not find any statistical difference between standard/usual treatment and evidence-based treatment groups in terms of number of admitted patients (3285 Vs. 2973), gender (76% male in both groups, and 24% female in both groups), age distribution (89% were ages between 15 to 55 in standard/usual group Vs. 89% in evidence based group), trauma type (blunt trauma; 66.6% in both groups, penetrating trauma; 33.4% in both groups) and measured blood alcohol levels (19.0% in both groups had >8mg/dl) However the overall mortality rate for the trauma patients treated with standard/usual care group was 10.7% compared to 4.1% for the trauma patients treated with evidence-based medicine, a 6.6% absolute reduction in mortality (RRR, 61.6%, 95%CI, 2.26-3.46,P<0.0001). Conclusion: Our study suggested that, implementation of evidence-based medicine methodology significantly reduces the mortality rate among the trauma patients treated in the Evidence-Based Medicine Group. Further studies are warranted.
Toxic effects of elm phytoalexin mansonones on Ophiostoma ulmi, the causal agent of dutch elm disease (1989)

Abstract The toxic effect of elm phytoalexins (mansonones) on two isolates of Ophiostoma ulmi was studied cytologically and physiologically. The effects included increasing ion leakage, reducing respiration rate and altering the structure of cellular organelles.
Ketoconazole and other imidazole derivatives are potent inhibitors of peroxisomal phytanic acid α‐oxidation (1995)

The imidazole antimycotics like ketoconazole, clotrimazole, bifonazole, miconazole and CO, known as powerful inhibitors of cytochrome P-450, are potent inhibitors of peroxisomal phytanic acid alpha-oxidation to pristanic acid suggesting the possible involvement of the cytochrome P-450 mono-oxygenase system in this oxidation. In contrast to the inhibition of the oxidation of [1-14C]phytanic acid, [1-14C]phytanoyl-CoA and [(2,3)-3H]phytanic acid, these drugs and CO have no effect on the oxidation of [1-14C]alpha-hydroxy phytanic acid indicating that these drugs and CO inhibit only the alpha-hydroxylation of phytanic acid. These studies using purified peroxisomes from liver and cultured human skin fibroblasts and Hep G2 cells clearly demonstrate that alpha-hydroxylation, an intermediate step in the alpha-oxidation of phytanic acid found to be impaired in Refsum Disease, is mediated by cytochrome P-450 containing enzyme.
Efficacy of ceftolozane in a murine model of Pseudomonas aeruginosa acute pneumonia: in vivo antimicrobial activity and impact on host inflammatory response (2012)

These data strongly support ceftolozane as an effective option for the treatment of severe P. aeruginosa respiratory infections by improving the early pulmonary inflammatory response without impairing 48 h post-infection homeostasis.
Query Intention Acquisition: A Case Study on Automatically Inferring Structured Queries (2006)

In rechargeable battery control and operation, one of the primary obstacles is safety concerns where the battery degradation poses a significant factor. Therefore, in recent years, state-of-health assessment of lithium-ion batteries has become a noteworthy issue. On the other hand, it is challenging to ensure robustness and generalization because most state-of-health assessment techniques are implemented for a specific characteristic, operating situation, and battery material system. In most studies, health status of single cell batteries is assessed by using analytical or computer-aided deep learning methods. But, the state-of-health characteristics of series-connected battery systems should be also focused with advances of technology and usage, especially electric vehicles. This study presents a data-driven, deep learning-based hybrid decision approach for predicting the state-of-health of series-connected lithium-ion batteries with different characteristics. The paper consists of generating series-connected battery degradation dataset by using of some mostly used datasets. Also, by employing deep learning-based networks along with hybrid-classification aided by performance metrics, it is shown that estimating and predicting the state-of-health can be achieved not only by using sole deep-learning algorithms but also hybrid-classification techniques. The results demonstrate the high accuracy and simplicity of the proposed novel approach on datasets from Oxford University and Calce battery group. The best estimated mean squared error, root mean square error and mean-absolute percentage error values are not more than 0.0500, 0.2236 and 0.7065, respectively which shows the efficiency not only by accuracy but also error indicators. The results show that the proposed approach can be implemented in offline or online systems with best average accuracy of 98.33 % and classification time of 58 ms per sample.
ChemInform Abstract: Preparation and Characterization of Noble Metal Solid Sols in Poly( methyl Methacrylate). (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cylindrical arrays with electronic beam scanning (1965)

This paper describes methods for enabling the directional pattern of a cylindrical array to scan continuously and repetitively through 360° by electronic means. This requires that the circular aperture distribution corresponding to the far-field directional pattern should be subjected to rotation relative to the fixed array. Methods are described for independent control of the amplitude and phase of the aperture distribution in order to synthetise suitable forms of directional pattern. Certain theoretical and practical limitations on the proposals are also discussed. The techniques are applicable, in principle, to both transmission and reception; a brief discussion of the relevance of the proposals to radar and sonar is also given.
Disruption of Imprinted Expression ofU2afbp-rs/U2af1-rs1 Gene in Mouse Parthenogenetic Fetuses (2001)

The present study shows that the U2afbp-rs gene, a paternally expressed imprinted gene, is activated and expressed in a biallelic manner from maternal alleles in parthenogenetic mouse fetuses on day 9.5 of gestation. The mean expression was detected to be 88% (31-134%) of that in control biparental fetuses, using real-time quantitative reverse transcription and polymerase chain reaction. This disrupted expression of the gene was associated with changes in the chromatin structure but not with the methylation pattern in the regulation region. The present results show that parental specific expression of imprinted genes is not always maintained in uniparental embryos. This suggests that both parental genomes are necessary to establish parental specific expression of the U2afbp-rs gene.
Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration (2007)

Hereditary spastic paraplegias (HSP) are neurodegenerative diseases mainly characterized by lower limb spasticity associated, in complicated forms, with additional neurological signs. We have analysed a large series of index patients (n = 76) with this condition, either from families with an autosomal recessive inheritance (n = 43) or isolated patients (n = 33), for mutations in the recently identified SPG11 gene. We found 22 truncating mutations, including the first four splice-site mutations, segregating in seven isolated cases and 13 families. Nineteen mutations were novel. Two recurrent mutations were found in Portuguese and North-African patients indicating founder effects in these populations. The mutation frequency varied according to the phenotype, from 41%, in HSP patients presenting with a thin corpus callosum (TCC) visualized by MRI, to 4.5%, in patients with mental impairment without a TCC. Disease onset occurred during the first to the third decade mainly by problems with gait and/or mental retardation. After a mean disease duration of 14.9 +/- 6.6 years, the phenotype of 38 SPG11 patients was severe with 53% of patients wheelchair bound or bedridden. In addition to mental retardation, 80% of the patients showed cognitive decline with executive dysfunction. Interestingly, the phenotype also frequently included lower motor neuron degeneration (81%) with wasting (53%). Slight ocular cerebellar signs were also noted in patients with long disease durations. In addition to a TCC (95%), brain MRI revealed white matter alterations (69%) and cortical atrophy (81%), which worsened with disease duration. In conclusion, our study reveals the high frequency of SPG11 mutations in patients with HSP, a TCC and cognitive impairment, including in isolated patients, and extends the associated phenotype.
Complete Amino Acid Sequence of 14 kDa  -Galactoside-Binding Lectin of Chick Embryo (1987)

The complete amino acid sequence of a soluble beta-galactoside-binding lectin (subunit MW 14,500) of chick embryo was determined. The protein consists of 134 amino acids beginning with serine and ending with glutamic acid, and its N-terminal was blocked with acetate. The agreement of the present result with that obtained from nucleotide sequence analysis (Y. Ohyama et al. (1986) Biochem. Biophys. Res. Commun. 134, 51-56) indicates the lack of a cleavable leader sequence. Internal homologies were observed in several regions along the polypeptide chain. The highest homology (55% identity) was found between residues 42-58 and residues 112-128. This suggests that chick 14 kDa lectin may have evolved via several gene duplications.
lndoor location estimation using multiple wireless technologies (2003)

.Abrrrurr-Future mobile devices will increasingly have multi,ple sources of location information associated with them, such as GPS. cellular ~ell-s~ctor ID. Bluetooth or 802.11 wireless LAN. I n fdct. cellular phones with GPS receivers and 802.11 wireless LAN are already becoming available. However, not all location technologies will operate e\,erywhere (e.g. GPS typically will not \wrk indoors whereas 802.11 coverage may be available) and they typically have different accuracies and range. This paper presents an experimental study of the feasibility 01 using multiple wireless technologies simultaneously for location We have collected signal strength information from 802.1 1 and Bluetooth wireless network technologies, developed and applied algorithms for determining location using data fur each wireless technology. and then used a simple algorithm far fusing t h e location estimates from both technologies to try to enhance the accuracy of the location estimates.
Antiproliferative Potential of Lithium Salts Against Hepatocellular Carcinoma Cell Line (2019)

To investigate the antiproliferative activity of nanosized particles of lithium salts against hepatocellular carcinoma cells line -29 (HCC-29) with special attention on apoptosis. HCC-29 cell line was inoculated by the intraperitoneal injection in mice. The different officinal and nanosized particles of the lithium salts effect on cell viability, and proliferation, and cell cycle distribution, and apoptosis, and membrane expression of GSK3β, was studied in vitro. The nanosized particle of lithium citrate and lithium carbonate treatment caused a reduction of survival rate, proliferation activity of HCC-29 cell line. Immunophenotype analysis revealed increased apoptosis by nanosized particles of lithium carbonate, and increased a number cell in subG0-G1 (apoptotic cells), and decreased the number of cells in G2-M phase. Nanosized particles of lithium citrate and lithium carbonate treatment also increased membrane expression of GSK-3β. The nanosized particle of lithium citrate and lithium carbonate suppresses cell viability and proliferation, induced apoptosis, especial lithium carbonate, and increased membrane expression of GSK-3β in vitro.
Principles of nuclear magnetic resonance. (1984)

The basic principles of nuclear magnetic resonance (NMR) are discussed. The concepts presented include a qualitative quantum-mechanical approach to NMR spectroscopy and a classical-mechanical approach to time-dependent NMR phenomena (relaxation effects). The spectroscopic concepts discussed include absorption of radiation by matter, spin and energy quantization , chemical shift, and spin-spin splitting. The time-dependent phenomena include the concepts of T1 and T2, the spin-lattice and spin-spin relaxation time, and Fourier-transform NMR spectroscopy.
Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition (1994)

A large number of different mutations in the factor VIII (F8) gene have been identified as a cause of haemophilia A. This compilation lists known single base-pair substitutions, deletions and insertions in the F8 gene and reviews the status of the inversional events which account for a substantial proportion of mutations causing severe haemophilia A.
Novel analgesics and molecular rearrangements in the morphine-thebaine group. VI. Base-catalyzed rearrangements in the 6,14-endo-ethenotetrahydrothebaine series (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel analgesics and molecular rearrangements in the morphine-thebaine group. VI. Base-catalyzed rearrangements in the 6,14-endo-ethenotetrahydrothebaine seriesKenneth W. Bentley, Denis G. Hardy, Henry P. Crocker, D. I. Haddlesey, and P. A. MayorCite this: J. Am. Chem. Soc. 1967, 89, 13, 3312–3321Publication Date (Print):June 1, 1967Publication History Published online1 May 2002Published inissue 1 June 1967https://pubs.acs.org/doi/10.1021/ja00989a035https://doi.org/10.1021/ja00989a035research-articleACS PublicationsRequest reuse permissionsArticle Views173Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermal stability of the Cu/PtSi metallurgy (1989)

Reaction between Cu and PtSi is studied over 200 to 700 °C. Using structures of Cu on a preformed PtSi, and of Cu on Pt/Si, Cu-PtSi reaction is observed below 300 °C for both structures, resulting in increasing sheet resistances above this temperature. The low thermal stability of the Cu/PtSi metallurgy, compared with that of Al/PtSi, is attributed to the ready formation of Cu silicides at low temperatures. Cu3 Si and Cu4 Si are observed for both Cu/PtSi and Cu/Pt/Si structures heated to 300–400 °C. Little improvement is obtained using an 1000 Å barrier layer of Ti, W, or Cr.
Effective values: an approach for characterizing dependability parameters (2002)

The authors discuss a novel direction for evaluating system dependability. The research efforts outlined are part of a special focus concerning the dependability of complex distributed systems at the Department of Computer Engineering of the Federal Armed Forces University in Munich, Germany. Our approach emphasizes the behavior of components after they have been embedded in a system. We use the notion of effective values for the analysis and estimation of key dependability parameters. The concept is targeted to unify performance characterization with the dependability. Besides analysis, we report on some simulation results, which were in favor of our assumptions.
Effective sunscreen ingredients and cutaneous irritation in patients with rosacea. (1998)

Patients with rosacea are particularly susceptible to the irritation caused by sunscreen ingredients. The purpose of this bilateral comparison study was to examine the effects of different ingredients found in sunscreen on facial cutaneous irritancy in patients with rosacea. patients clinically diagnosed with rosacea were asked to test different preparations of common sunscreens on their faces. The results show that the presence or absence of appropriate protective ingredients, such as dimethicone and cyclomethicone in the vehicle, may prevent irritation from other sunscreen ingredients in patients with inflammatory conditions such as rosacea.
237. The production of active solids by thermal decomposition. Part XI. The heat treatment of precipitated stannic oxide (1960)

J. F. Goodman and S. J. Gregg, J. Chem. Soc., 1960, 1162 DOI: 10.1039/JR9600001162
Frequent Carriage of Panton-Valentine Leucocidin Genes by <i>Staphylococcus aureus</i> Isolates from Surgically Drained Abscesses (2005)

ABSTRACT Between 1 February and 15 April 2002, 95 patients were admitted to Gaston Bourret Territorial Hospital (New Caledonia, France) for drainage of community-acquired soft tissue abscesses. Staphylococcus aureus was detected in 68 cases (72%). Two-thirds of the patients with S. aureus infection had furuncles, which were located on the limbs in 82% of cases. The median interval between symptom onset and hospital admission was 5.7 days. Three-quarters of the patients were Melanesians living in tribes. Fifty-four S. aureus isolates were screened for toxin genes. Panton-Valentine leucocidin (PVL) genes were detected in 48 isolates (89%), the exfoliative toxin A gene was detected in 1 isolate, and no toxin genes were detected in 4 isolates. S. aureus nasal carriage was detected in 39.7% of patients with S. aureus infections. Two infecting S. aureus strains and two nasal carriage strains were resistant to methicillin. Comparative pulsed-field gel electrophoresis, performed in 16 cases, showed that five of six patients with PVL-positive nasal carriage strains were infected by the same strains. In contrast, 8 of 10 patients with PVL-negative nasal carriage strains were infected by PVL-positive strains. PVL genes thus appear to be a major virulence factor in both primary and secondary S. aureus skin infections.
A Guaranteed Lifetime Protocol for Real-Time Wireless Sensor Networks (2014)

Due to the stringent energy constraint wireless "s, network management cost for lifetime becomes" "sensor node" "one of the crucial issues in designing wireless sensor networks (WSNs). In such situation, guaranteed network lifetime is more preferred than unpredictable pro-long one. However, despite of its importance and necessity in real world deployment, few research works have been proposed to solve this complex problem by ideal approach with the lack of applicability. In this paper, we present a new centralized scheduling mechanism to guarantee network lifetime to a pre-determined time while maintaining k-coverage of network field. In order to guarantee network lifetime, each node are enforced to remain steadfast in the idle state for a known duration of its lifetime. In addition, the scheduling algorithm is extended to provide real-time service by adjusting transmission range according to current energy state of a sensor node. These two core functions are implemented by deciding each nodes role in the next round according to nodes energy consumption and active time history in decision phase. The performance of proposed scheme is compared with well-known A-MAC and MMSPEED protocols in terms of guaranteed lifetime and real-time respectively.
From ACE to the G-15 (1984)

The 1946 Turing proposal for a stored-program computer at Britain's National Physical Laboratory is briefly described. The author's participation in the Test Assembly design, NPL's design of the ACE Pilot Model, and the subsequent design of the ACE are presented. The author's return to the United States and his efforts to build a similar computer at the National Bureau of Standards are described. Finally, the design of the Bendix G-15 and how it is related to the other computers is discussed. These computers were characterized by having re-circulating memories and logical designs that permitted the execution of several instructions per memory cycle.