gebhart/patrepeval huggingface dataset:
A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene. (1990)

A novel cis-acting regulatory element (designated BTE for basic transcription element) was found in the region proximal to the TATA sequence of the P-450c gene by the use of deletion mutations. This DNA element is considered to be involved in the basic transcription of the gene and does not show distinct enhancer activity in itself. Together with the XRE sequence (A. Fujisawa-Sehara, K. Sogawa, M. Yamane, and Y. Fujii-Kuriyama, Nucleic Acids Res. 15:4179-4191, 1987), however, this sequence is required for a high inducible expression of the P-450c gene in response to xenobiotic inducers. The BTE sequence contained the GC box consensus sequence and half of the NF-1-binding consensus or CAT box sequence, but their synthetic oligonucleotides, used as competitors in the gel mobility shift assays, did not compete with the BTE sequence for the binding protein, suggesting that the BTE sequence functions as a different recognition sequence from that for Sp1 or NF-1. Analogous sequences to BTE are found in the region proximal to the TATA sequence of other genes, especially other P-450 genes with different modes of regulation, suggesting that the BTE sequence plays a common regulatory role in basic transcription of genes including a group of the P-450 superfamily. The ubiquitous distribution of nuclear factor(s) binding to this element supports this suggestion.
p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability (2012)

p32 is an evolutionarily conserved and ubiquitously expressed multifunctional protein. Although p32 exists at diverse intra and extracellular sites, it is predominantly localized to the mitochondrial matrix near the nucleoid associated with mitochondrial transcription factor A. Nonetheless, its function in the matrix is poorly understood. Here, we determined p32 function via generation of p32-knockout mice. p32-deficient mice exhibited mid-gestation lethality associated with a severe developmental defect of the embryo. Primary embryonic fibroblasts isolated from p32-knockout embryos showed severe dysfunction of the mitochondrial respiratory chain, because of severely impaired mitochondrial protein synthesis. Recombinant p32 binds RNA, not DNA, and endogenous p32 interacts with all mitochondrial messenger RNA species in vivo. The RNA-binding ability of p32 is well correlated with the mitochondrial translation. Co-immunoprecipitation revealed the close association of p32 with the mitoribosome. We propose that p32 is required for functional mitoribosome formation to synthesize proteins within mitochondria.
Extended testing of compression distillation. (1972)

During the past eight years, the NASA Manned Spacecraft Center has supported the development of an integrated water and waste management system which includes the compression distillation process for recovering useable water from urine, urinal flush water, humidity condensate, commode flush water, and concentrated wash water. This paper describes the design of the compression distillation unit, developed for this system, and the testing performed to demonstrate its reliability and performance. In addition, this paper summarizes the work performed on pretreatment and post-treatment processes, to assure the recovery of sterile potable water from urine and treated urinal flush water.
Hydrolysis of Dimethyl Methylphosphonate by the Cyclic Tetramer of Zirconium Hydroxide (2017)

We present hybrid density functional theory (DFT) calculations of hydrolysis of dimethyl methylphosphonate (DMMP) by the cyclic tetramer of zirconium hydroxide [Zr<sub>4</sub>(OH)<sub>16</sub>]. Various binding configurations of DMMP and its hydrolysis products on the tetramer as well as transition structures connecting them were explored using structure optimizations based on multiple, randomly selected initial structures. We find that DMMP can bind to the tetramer through the phosphoryl O, forming either a strong hydrogen bond to a bridging hydroxyl or a coordinate bond to a coordinatively unsaturated Zr atom. The resulting hydrogen-bonded complexes and Lewis adducts have similar energies. We also find that hydrolysis of a P-OCH<sub>3</sub> bond can occur either via an addition-elimination mechanism involving a same-site terminal hydroxyl or direct interchange between a terminal hydroxyl and a methoxy group of DMMP. The computed activation and reaction enthalpies show that the addition-elimination is both kinetically and thermodynamically favored over the direct interchange. Our findings support recent observations of the reactivity of amorphous zirconium hydroxide toward phosphonate esters including chemical warfare agents.
Distribution of trapped charges in SiO/sub 2/ film of a p/sup +/-gate PMOS structure (1991)

To investigate the highly boron-doped SiO/sub 2/ film, p/sup +/ polysilicon-gate PMOSFETs and capacitors were fabricated using the same process as is used for surface-channel-type n/sup +/-gate devices, except for the gate-type doping. After the application of negatively biased Fowler-Nordheim (FN) stress, it was found that positive charges accumulate near the silicon/SiO/sub 2/ interface and electrons accumulate near the polysilicon/SiO/sub 2/ interface in p/sup +/-gate capacitors. DC hot carrier stress was applied to both PMOSFET gate types. The p/sup +/ gate's stress time dependence of I/sub sub/ is smaller than that of the n/sup +/ gate, and the electric field near the drain in the p/sup +/-gate PMOSFET was found to be more severe than that of the n/sup +/-gate device. The subthreshold slope of the p/sup +/-gated PMOSFET was improved and then degraded during the hot carrier stressing, while that of the n/sup +/-gated device did not significantly change. The actual change of V/sub th/ was larger than the value derived from Delta /sub gm/ using the channel-shortening concept. The idea of widely spreading and partially compensated electron distribution along with source-drain direction in the SiO/sub 2/ film, which assumes the existence of trapped holes in the p/sup +/-gate PMOSFET, is proposed to explain these phenomena.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Handbook of Veterinary Drugs: A Compendium for Research and Clinical Use (1975)

abattre pour les raisons suivantes: mammite recurrente, pietre production lactee et perte de poids.
Effect of Ions on the Structure of Water: Structure Making and Breaking (2009)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTEffect of Ions on the Structure of Water: Structure Making and BreakingYizhak MarcusView Author Information Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, IsraelCite this: Chem. Rev. 2009, 109, 3, 1346–1370Publication Date (Web):February 23, 2009Publication History Received11 December 2007Published online23 February 2009Published inissue 11 March 2009https://pubs.acs.org/doi/10.1021/cr8003828https://doi.org/10.1021/cr8003828review-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views26506Altmetric-Citations1437LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Hydration,Ions,Molecules,Noncovalent interactions,Solution chemistry Get e-Alerts
A Method of Trapping the Confused flour Beetle, Tribolium Confusum Duval (1931)

Corrugated paper containing wheat flour as an attrahent proved to be an efficient trap for the confused flour beetle (Tribolium Confusum Duval) in shelled corn. Eighty-five thousand five hundred beetles were captured in traps during 961 trapping hours, or 40 trapping days. The insects were trapped in moth rooms where large numbers of grain infesting insects were present. The average number of beetles captured in traps 6½ by 5½ inches in size during 72 hour exposure periods was 46.4.
Stackelberg Game Based Cooperative User Relay Assisted Load Balancing in Cellular Networks (2013)

We propose a Stackelberg game based cooperative user relay assisted load balancing (LB) scheme to tackle SNR degradation problem of shifted cell-edge users which commonly occurs in a conventional direct handover LB scheme. In the proposed scheme, users from a lightly loaded cell can be selected as cooperative user-relays and will be paid by the shifted cell-edge users. Stackelberg game theory is applied to optimize the strategies of both the user relays and shifted cell-edge users, in order to maximize both of their utilities in terms of SNR and payment. Theoretical analysis and simulation study are undertaken to show the effectiveness of the proposed scheme.
Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women—A Randomized Controlled Study (2018)

<b>Introduction:</b> Investigations in rodents as well as in vitro experiments have suggested an anabolic influence of specific collagen peptides (SCP) on bone formation and bone mineral density (BMD). The goal of the study was to investigate the effect of 12-month daily oral administration of 5 g SCP vs. placebo (CG: control group) on BMD in postmenopausal women with primary, age-related reduction in BMD. <b>Methods:</b> 131 women were enrolled in this randomized, placebo-controlled double-blinded investigation. The primary endpoint was the change in BMD of the femoral neck and the spine after 12 months. In addition, plasma levels of bone markers-amino-terminal propeptide of type I collagen (P1NP) and C-telopeptide of type I collagen (CTX 1)-were analysed. <b>Results:</b> A total of 102 women completed the study, but all subjects were included in the intention-to-treat (ITT) analysis (age 64.3 ± 7.2 years; Body Mass Index, BMI 23.6 ± 3.6 kg/m²; T-score spine -2.4 ± 0.6; T-score femoral neck -1.4 ± 0.5). In the SCP group (<i>n</i> = 66), BMD of the spine and of the femoral neck increased significantly compared to the control group (<i>n</i> = 65) (T-score spine: SCP +0.1 ± 0.26; CG -0.03 ± 0.18; ANCOVA <i>p</i> = 0.030; T-score femoral neck: SCP +0.09 ± 0.24; CG -0.01 ± 0.19; ANCOVA <i>p</i> = 0.003). P1NP increased significantly in the SCP group (<i>p</i> = 0.007), whereas CTX 1 increased significantly in the control group (<i>p</i> = 0.011). <b>Conclusions:</b> These data demonstrate that the intake of SCP increased BMD in postmenopausal women with primary, age-related reduction of BMD. In addition, SCP supplementation was associated with a favorable shift in bone markers, indicating increased bone formation and reduced bone degradation.
Electron beam ion sources and their development at JINR (invited) (1990)

The principles of action and main types of electron beam ion sources (EBIS) developed in various laboratories are considered. The reasons limiting an ability of EBIS to ionize are discussed. Primary consideration is given to the program of EBIS development at the Joint Institute for Nuclear Research at Dubna. The method of ion-by-ion cooling and preliminary results of its study for increasing the highly charged ion yield and for increasing the charge state of ions are described. The ion-at-surface spectroscopy is shown as a useful diagnostic method of EBIS. Possible prospects for development of EBIS and for its application are pointed out.
Properties of GMP-140, an inducible granule membrane protein of platelets and endothelium. (1990)

GMP-140 is an integral membrane glycoprotein with an apparent Mr of 140,000 located in secretory granules of human platelets and endothelial cells. When these cells are stimulated, the protein is rapidly redistributed to the plasma membrane; therefore, monoclonal antibodies to GMP-140 are useful markers of activated platelets and endothelium. GMP-140 is cysteine-rich and heavily glycosylated. The cDNA-derived amino acid sequence indicates that it contains a number of modular domains that are likely to fold independently. Beginning at the N-terminus, these comprise a "lectin" domain, an "EGF" domain, nine tandem consensus repeats similar to those in complement-binding proteins, a transmembrane domain, and a cytoplasmic tail. Some cDNAs also predict variant forms of GMP-140, including a putative soluble form lacking the transmembrane domain that appears to arise from alternative splicing of mRNA. The domain organization of GMP-140 is strikingly similar to two other vascular cell surface structures: ELAM-1, a cytokine-inducible endothelial cell receptor that binds neutrophils, and a lymphocyte-homing receptor that mediates the adherence of lymphocytes to high endothelial venules of peripheral lymph nodes. These "selectins" constitute a new gene family of receptors with related structure and potentially related function.
Trends in surge protection of electronic equipment (1996)

Lightning-induced surges have posed a significant threat to electronic equipment for many years, especially since semiconductors superseded thermionic technology. In this paper, an attempt is made to identify trends which will determine the likely prospects for electronic equipment over the next few years. First, some of the factors determining susceptibility to damage are considered: (i) the frequency of lightning discharges; (ii) equipment susceptibility; and (iii) economic factors. Methods of protection are then reviewed. In conclusion, the authors discuss protection components and the effect of standardisation of surge protection devices.
The influence of timing and the addition of urea to supplements containing DL-methionine on ruminal fermentation and cow weight change in beef cows1 (1991)

A study was conducted to determine an optimal time for supplementation of DL-methionine in relation to time of forage intake by mature British breed-type crossbred cows, and two other experiments were conducted to determine whether ruminal ammonia concentration limited changes in disappearance rates in situ and ruminal functions caused by supplements containing DL-methionine. Experiments 1 and 2 used 4 x 4 Latin square designs with four cows in each experiment. Treatments in Exp. 1 were no supplement (CON), DL-methionine at feeding (0800), DL-methionine 4 h after feeding (1200), and DL-methionine 7 h after feeding (1500). Treatments in Exp. 2 were .5 kg of beet pulp (CON), .5 kg of beet pulp plus 16.5 g of DL-methionine (MET), .5 kg of beet pulp plus 16.5 g of DL-methionine and 55 g of urea (METU), and .4 kg of soybean (SOY). Experiment 3 was conducted in a 326-ha pasture with treatments of no supplement (CON), .5 kg of beet pulp plus 12.5 g of DL-methionine and 30 g of urea (METU), and .4 of kg soybean meal (SOY). In Exp. 1, in situ NDF disappearance rates of cows supplemented at 1200 and 1500 were greater (P less than .01) than those of cows supplemented at 0800. In Exp. 2, ruminal ammonia concentration was greatest (P less than .001) for METU (5.2 mg/dl) and least for CON (1.5 mg/dl). Disappearance rates in situ for DM differed (P less than .01) among treatments; METU was similar (P greater than .2) to SOY but faster (P less than .01) than MET. Disappearance rates of NDF were greatest (P less than .001) for METU-supplemented cows. In Exp. 3, DM and NDF disappearance rates were faster (P less than .10) for SOY than for METU. Cow BW change was positive for METU and SOY, and decrease in condition score was least (P less than .10) for METU- and SOY-treated cows. These studies indicate favorable ruminal responses to DL-methionine supplementation; however, the response depended on time of supplementation and ruminal ammonia concentration.
Epidemiology of atrial fibrillation: European perspective (2014)

In the last 20 years, atrial fibrillation (AF) has become one of the most important public health problems and a significant cause of increasing health care costs in western countries. The prevalence of AF is increasing due to our greater ability to treat chronic cardiac and noncardiac diseases, and the improved ability to suspect and diagnose AF. At the present time, the prevalence of AF (2%) is double that reported in the last decade. The prevalence of AF varies with age and sex. AF is present in 0.12%-0.16% of those younger than 49 years, in 3.7%-4.2% of those aged 60-70 years, and in 10%-17% of those aged 80 years or older. In addition, it occurs more frequently in males, with a male to female ratio of 1.2:1. The incidence of AF ranges between 0.21 and 0.41 per 1,000 person/years. Permanent AF occurs in approximately 50% of patients, and paroxysmal and persistent AF in 25% each. AF is frequently associated with cardiac disease and comorbidities. The most common concomitant diseases are coronary artery disease, valvular heart disease, and cardiomyopathy. The most common comorbidities are hypertension, diabetes, heart failure, chronic obstructive pulmonary disease, renal failure, stroke, and cognitive disturbance. Paroxysmal AF occurs in younger patients and with a reduced burden of both cardiac disease and comorbidities. Generally, the history of AF is long, burdened by frequent recurrences, and associated with symptoms (in two thirds of patients). Patients with AF have a five-fold and two-fold higher risk of stroke and death, respectively. We estimate that the number of patients with AF in 2030 in Europe will be 14-17 million and the number of new cases of AF per year at 120,000-215,000. Given that AF is associated with significant morbidity and mortality, this increasing number of individuals with AF will have major public health implications.
Unrepeated transmission of 20-Gb/s optical quadrature phase-shift-keying signal over 200-km standard single-mode fiber based on digital processing of homodyne-detected signal for Group-velocity dispersion compensation (2006)

We demonstrate unrepeated optical transmission of 20-Gb/s quadrature phase-shift-keying (QPSK) signals over a 200-km-long standard single-mode fiber (SMF) without using any optical dispersion compensator. By employing optical homodyne detection, which can restore the entire information of the complex amplitude of the transmitted signal, group-velocity dispersion (GVD) of the SMF can be compensated electrically by a linear equalizer at the receiver. From off-line bit-error-rate measurements, we find that a simple transversal filter implemented in digital signal processing circuits after homodyne detection can effectively cancel the fiber GVD of up to 4000 ps/nm, enabling successful 20-Gb/s QPSK transmission.
Changes in the zein composition of protein bodies during maize endosperm development. (1989)

Zeins, the seed storage proteins of maize, are synthesized during endosperm development by membrane-bound polyribosomes and transported into the lumen of the endoplasmic reticulum, where they assemble into protein bodies. To better understand the distribution of the various zeins throughout the endosperm, and within protein bodies, we used immunolocalization techniques with light and electron microscopy to study endosperm tissue at 14 days and 18 days after pollination. Protein bodies increase in size with distance from the aleurone layer of the developing endosperm; this reflects a process of cell maturation. The protein bodies within the subaleurone cell layer are the smallest and contain little or no alpha-zein; beta-zein and gamma-zein are distributed throughout these small protein bodies. The protein bodies in cells farther away from the aleurone layer are progressively larger, and immunostaining for alpha-zein occurs over locules in the central region of these protein bodies. In the interior of the largest protein bodies, the locules of alpha-zein are fused. Concomitant with the appearance of alpha-zein in the central regions of the protein bodies, most of the beta- and gamma-zeins become peripheral. These observations are consistent with a model in which specific zeins interact to assemble the storage proteins into a protein body.
Modification of LiCoO2 by Surface Coating with MgO / TiO2 / SiO2 for High-Performance Lithium-Ion Battery (2006)

coated has been successfully prepared as a cathode material for lithium-ion batteries. A thin layer of solid solution was identified at the surface of , which helped to improve the cycle-reversibility, overcharge stability, thermal stability, and to lower impedance of the test lithium-ion battery.
Cloning, nucleotide sequence, and regulation of Schizosaccharomyces pombe thi4, a thiamine biosynthetic gene (1994)

thi4 mutants of Schizosaccharomyces pombe exhibit defective thiamine biosynthesis, and thi4 mutations define a gene which is believed to be involved in the phosphorylation of 4-amino-5-hydroxymethyl-2-methylpyrimidine or 5-(2-hydroxyethyl)-4-methylthiazole and/or in the coupling of the two phosphorylated precursors to thiamine monophosphate (A. M. Schweingruber, J. Dlugonski, E. Edenharter, and M. E. Schweingruber, Curr. Genet. 19:249-254, 1991). The thi4 gene was cloned by functional complementation of a thi4 mutant and physically mapped on the left arm of chromosome I close to the genetic marker gln1. The thi4-carrying DNA fragment shows an open reading frame encoding a protein of 518 amino acids and a calculated molecular mass of 55.6 kDa. The appearance of thi4 mRNA is strongly repressed by thiamine and to a lesser extent by 5-(2-hydroxyethyl)-4-methylthiazole. thi4 mRNA production is under the control of the thi1 gene-encoded transcription factor and of the negative regulators encoded by genes tnr1, tnr2, and tnr3. thi4 is expressed and regulated in manners similar to those of other S. pombe genes involved in thiamine metabolism, including thi2, thi3, and pho4.
A MISLEADING SAFETY RECORD (1984)

Comparing the safety record of school buses to that of automobiles does not account for the nonschool time when automobiles are used. Experiences where seat belts are installed in school buses show that students use them, insurance is not a problem, and cost is slight. Language: en
A prototype 4800 bps voice terminal for the mobile satellite experiment (1987)

The authors report the final stage of a research project for the NASA mobile satellite experiment (MSAT-X). The work has resulted in two alternative coding techniques which have achieved good communications quality at 4.8 kb/s while tolerating vehicle noise, fading, and a fairly high-error-rate, bursty channel. The authors have constructed a circuit board based on three AT&T 32-bit floating-point DSP32 digital signal processors (DSP) and providing both excess processing power and considerable flexibility for handling different variations of the algorithms. A Motorola 68HC11 microcomputer chip serves as the board controller and interface handler. Mounted on a wirewrapped card, the prototype's circuit footprint amounts to only 225 cm2 and consumes about 13 W of power. A description is given of the architecture, signal processing and communication functions, circuitry, and firmware of the prototype. Issues such as synchronization, framing, error control, and modem interface are also addressed.