gebhart/patrepeval huggingface dataset:
Direct crosslinks between initiation factors 1, 2, and 3 and ribosomal proteins promoted by 2-iminothiolane (1983)

Complexes were prepared containing 30S ribosomal subunits from Escherichia coli and the three initiation factors IF1, IF2, and IF3. In different experiments, each of the factors was radiolabeled with the others unlabeled. The complexes were allowed to react with 2-iminothiolane and then oxidized to promote the formation of intermolecular disulfide bonds, some of which were between factors and ribosomal proteins. Each of the labeled factors becomes covalently cross-linked to the complex as judged by its failure to dissociate when centrifuged in a sucrose gradient containing a high salt concentration. Proteins from the complexes were extracted and analyzed on two-dimensional polyacrylamide gels by nonequilibrium isoelectric focusing and sodium dodecyl sulfate gel electrophoresis. Spots corresponding to cross-linked dimers that contained initiation factors, as indicated on autoradiographs, were cut out and analyzed further. The following cross-linked dimers between factors and ribosomal proteins were identified: IF1-S12, IF1-S18, IF2-S13, IF3-S7, IF3-S11, IF3-S13, and IF3-S19. Cross-links between factors IF1-IF2 and IF3-IF2 were also identified. A model integrating these findings with others on the protein topography of the ribosome is presented.
The Public Historian in Human Resource Development and Management (1986)

Research Article| October 01 1986 The Public Historian in Human Resource Development and Management D. M. Page D. M. Page Search for other works by this author on: This Site PubMed Google Scholar The Public Historian (1986) 8 (4): 7–26. https://doi.org/10.2307/3377497 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation D. M. Page; The Public Historian in Human Resource Development and Management. The Public Historian 1 October 1986; 8 (4): 7–26. doi: https://doi.org/10.2307/3377497 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Public Historian Search This content is only available via PDF. Copyright 1986 The Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.
The Perfect Club Benchmarks: Effective Performance Evaluation of Supercomputers (1989)

This report presents a methodology for measuring the performance of supercomputers. It includes 13 Fortran programs that total over 50,000 lines of source code. They represent applications in several areas of engi neering and scientific computing, and in many cases the codes are currently being used by computational re search and development groups. We also present the PERFECT Fortran standard, a set of guidelines that allow portability to several types of machines. Furthermore, we present some performance measures and a method ology for recording and sharing results among diverse users on different machines. The results presented in this paper should not be used to compare machines, except in a preliminary sense. Rather, they are presented to show how the methodology has been applied, and to encourage others to join us in this effort. The results should be regarded as the first step toward our objec tive, which is to develop a publicly accessible data base of performance information of this type.
Image subtraction using a space-varying kernel (2000)

Image subtraction is a method by which one image is matched against another by using a convolution kernel, so that they can be differenced to detect and measure variable objects. It has been demonstrated that constant optimal-kernel solutions can be derived over small sub-areas of dense stellar fields. Here we generalize the theory to the case of space-varying kernels. In particular, it is shown that the CPU cost required for this new extension of the method is almost the same as for fitting a constant kernel solution. It is also shown that constant flux scaling between the images (constant kernel integral) can be imposed in a simple way. The method is demonstrated with a series of Monte-Carlo images. Differential PSF variations and differential rotation between the images are simulated. It is shown that the new method is able to achieve optimal results even in these difficult cases, thereby automatically correcting for these common instrumental problems. It is also demonstrated that the method does not suffer due to problems associated with under-sampling of the images. Finally, the method is applied to images taken by the OGLE II collaboration. It is proved that, in comparison to the constant-kernel method, much larger sub-areas of the images can be used for the fit, while still maintaining the same accuracy in the subtracted image. This result is especially important in case of variables located in low density fields, like the Huchra lens. Many other useful applications of the method are possible for major astrophysical problems; Supernova searches and Cepheids surveys in other galaxies, to mention but two. Many other applications will certainly show-up, since variability searches are a major issue in astronomy.
miR-29b as a Therapeutic Agent for Angiotensin II-induced Cardiac Fibrosis by Targeting TGF-β/Smad3 signaling (2014)

Loss of miR-29 is associated with cardiac fibrosis. This study examined the role and therapeutic potential of miR-29 in mouse model of hypertension induced by angiotensin II (AngII). By using microRNA microarray, in situ hybridization, and real-time polymerase chain reaction, we found that AngII-induced cardiac fibrosis in the hypertensive heart and in cultured cardiac fibroblasts were associated with downregulation of miR-29a-c via a Smad3-dependent mechanism. In vitro knockdown of miR-29b enhanced but overexpression of miR-29b inhibited AngII-induced fibrosis, revealing a protective role of miR-29b in cardiac fibrosis in response to AngII. This was further demonstrated in vivo by the ability of overexpressing miR-29b in the mouse heart to prevent AngII-mediated cardiac fibrosis and cardiac dysfunction. Importantly, we also found that restored miR-29b in the established hypertensive heart was capable of blocking progressive cardiac fibrosis and improving cardiac dysfunction, demonstrating a therapeutic potential of miR-29b for chronic heart disease. Further studies revealed that targeting the transforming growth factor (TGF)-β1 coding sequence region, thereby inhibiting TGF-β/Smad3 signaling, could be a new mechanism by which miR-29b inhibited AngII-induced cardiac fibrosis. In conclusion, miR-29b plays a protective role in AngII-mediated cardiac remodeling and may be a therapeutic agent for cardiac fibrosis by targeting the TGF-β/Smad3 pathway.
Interactive and Exact Collision Detection for Multi-Body Environments (1994)

We present an algorithm for exact collision detection in interactive environments. Such environments are characterized by the number of objects undergoing motion and the complexity of the models. We do not assume that the motions of the objects are expressible as closed-form functions of time, nor do we assume any limitations on their velocities. The algorithm uses a two-level hierarchical representation for each model to selectively compute the precise contact between objects, achieving real-time performance without compromising accuracy. In large environments with n moving objects, it uses the temporal and geometric coherence that exists between successive frames to overcome the bottleneck of O(n²) pairwise comparisons. The algorithm has been successfully demonstrated in architectural walkthrough and simulated environments. In particular, the algorithm takes less than 1/20 of a second to determine all the collisions and contacts in an environment consisting of more than 1000 mo...
.gamma.-Bromo- and .gamma.-iodoacetoacetanilides (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.gamma.-Bromo- and .gamma.-iodoacetoacetanilidesMohamed I. Ali, M. Amine Abou-State, and Nabil M. HassanCite this: J. Chem. Eng. Data 1972, 17, 1, 106–108Publication Date (Print):January 1, 1972Publication History Published online1 May 2002Published inissue 1 January 1972https://pubs.acs.org/doi/10.1021/je60052a008https://doi.org/10.1021/je60052a008research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Relationship of intraoperative electrically evoked stapedius reflex thresholds to maximum comfortable loudness levels of children with cochlear implants: Relaciones entre los umbrales transquirürgicos del reflejo estapedial eléctricamente evocado y los niveles máximos de sonoridad agradable en niños con implantes cocleares (2002)

Previous studies of the relationship between the intraoperatively obtained electrically evoked stapedius reflex threshold (ESRT) and the maximum comfortable loudness (MCL) values used to program the speech processor of cochlear implant (CI) patients have indicated that ESRTs provide an inexact estimate of MCL. In order to determine whether this estimate might be more exact for electrodes in different parts of the electrode array, we studied the electrode-specific relationships between ESRT and MCL in 29 Med-E1 Combi 40+ and 25 Nucleus CI 24 M patients after first fitting of the speech processor and 2 and 6 months later. The MCL values were mostly less than the ESRT values, but increased progressively over the first 6 months, reaching 83% and 72% of the ESRT values, on average, across all electrodes for the Med-E1 and Nucleus systems respectively. The population variation across electrodes decreased over the 6-month observation period and was least for the apical half of the array, for which the correlation coefficients of regressions between ESRT and MCL were around 0.65 for both systems. These results indicate that estimates of MCL values from the ERST are more accurate for the apical half of the intra-cochlear array and could then be described by an offset value plus an increase of MCL by 0.62 and 0.53 of ESRT for the Med-E1 and Nucleus systems, respectively.
Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors (2014)

The discovery and clinical development of heat shock protein 90 (Hsp90) inhibitors continue to progress. A number of Hsp90 inhibitors are in clinical trials, and preclinical discoveries of new chemotypes that bind to distinct regions in the protein as well as isoform selective compounds are active areas of research. This review will highlight progress in the field since 2010.
The use of seaweed from the Galician coast as a mineral supplement in organic dairy cattle (2014)

This study was designed to assess the value of seaweeds from the Galician coast as a source of minerals (especially iodine (I) but also other micro-minerals) in organic dairy cattle. It was conducted in an organic dairy farm in the Lugo province that typically represents the organic milk production in NW Spain. The animal's diet consisted mainly of local forage (at pasture or as hay and silage in the winter) and 5 kg of purchased concentrate/day per animal (representing 23.5% of feed intake). Based on the mineral composition of the diet, the physiological requirements and the EU maximum authorised levels in feed, a supplement composed by Sea Lettuce (Ulva rigida) (as flakes, 80%), Japanese Wireweed (Sargasum muticum) (flakes, 17.5%) and Furbelows (Saccorhiza polyschides) (powder, 2.5%) was formulated to give 100 g/animal per day. Sixteen Holstein Friesian lactating cows were randomly selected and assigned to the control (n=8) and algae-supplemented groups (n=8). Both groups had exactly the same feeding and management with the exception of the algae supplement, which was mixed with the concentrate feed and given to the animals at their morning milking for 10 weeks. Heparinised blood (for plasma analysis) and milk samples were collected at 2-week intervals and analysed for toxic and trace element concentrations by inductively coupled plasma-mass spectrometry or inductively coupled plasma-optical emission spectrometry. The algae supplement significantly improved the animals' mineral status, particularly I and selenium that were low on the farm. However, the effect of the algae supplement on the molybdenum status in cattle needs further investigation because of its great relevance on copper metabolism in ruminants. The I supply deserves special attention, since this element is at a very high concentration in brown-algae species and it is excreted in the milk proportionally to its concentration in plasma concentrations (mean ± s.e. in the algae-supplemented and control groups were 268 ± 54 and 180 ± 42 µg/l, respectively).
The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems. (1996)

The experiments reported here were designed to test the hypothesis that the two-electron quinone reductase DT-diaphorase [NAD(P)H:(quinone-acceptor) oxidoreductase, EC 1.6.99.2] functions to maintain membrane-bound coenzyme Q (CoQ) in its reduced antioxidant state, thereby providing protection from free radical damage. DT-diaphorase was isolated and purified from rat liver cytosol, and its ability to reduce several CoQ homologs incorporated into large unilamellar vesicles was demonstrated. Addition of NADH and DT-diaphorase to either large unilamellar or multilamellar vesicles containing homologs of CoQ, including CoQ9 and CoQ10, resulted in the essentially complete reduction of the CoQ. The ability of DT-diaphorase to maintain the reduced state of CoQ and protect membrane components from free radical damage as lipid peroxidation was tested by incorporating either reduced CoQ9 or CoQ10 and the lipophylic azoinitiator 2,2'-azobis(2,4-dimethylvaleronitrile) into multilamellar vesicles in the presence of NADH and DT-diaphorase. The presence of DT-diaphorase prevented the oxidation of reduced CoQ and inhibited lipid peroxidation. The interaction between DT-diaphorase and CoQ was also demonstrated in an isolated rat liver hepatocyte system. Incubation with adriamycin resulted in mitochondrial membrane damage as measured by membrane potential and the release of hydrogen peroxide. Incorporation of CoQ10 provided protection from adriamycin-induced mitochondrial membrane damage. The incorporation of dicoumarol, a potent inhibitor of DT-diaphorase, interfered with the protection provided by CoQ. The results of these experiments provide support for the hypothesis that DT-diaphorase functions as an antioxidant in both artificial membrane and natural membrane systems by acting as a two-electron CoQ reductase that forms and maintains the antioxidant form of CoQ. The suggestion is offered that DT-diaphorase was selected during evolution to perform this role and that its conversion of xenobiotics and other synthetic molecules is secondary and coincidental.
Controller design for mixed l/sub 1//LMI performance objectives (2005)

In this paper we study norm minimization problems, and in particular the l/sub 1/ optimal control problem, subject to linear matrix inequality (LMI) constraints. We show how LMI's can be recast as parametrized LP's, and from this develop a sufficient condition for the lack of a duality gap for such problems in the infinite dimensional case. We give an exact characterization of the primal and dual problems in this case. In the case that we use the l/sub 1/ norm then both primal and dual problems can be posed as LMI optimization problems.
API peer reviews (2010)

API usability tests in the lab are time and resource intensive, thus allowing a relatively small percentage of the API namespace to be evaluated. We describe a group-based usability inspection method -- API Peer Reviews -- to evaluate API usability. Based on an analysis of usability breakdowns from API Peer Reviews and API usability tests, results show that API Peer Reviews identified breakdowns across several cognitive dimensions, some of which were different than what was identified by API usability tests. We reflect on the adoption of API Peer Reviews as a collaborative practice in organizations for evaluating API usability.
Heuristic approach to the recognition of printed Arabic script (2002)

A new segmentation-free method, called N-markers, is proposed for machine recognition of the Arabic printed texts. The contribution aims at the optical character recognition of printed texts, like books and journals of good quality, usually typeset in so-called Naskhi font. The focus of attention is shifted from the recognition of multifont texts to that of single Naskhi font, taking, however, into account shape variations originated in different typesetting workshops, and the intensive presence of the ligatures in normal printed texts. The proposed method is a mixture of global and structural approaches and is related to some early ideas of the optical character recognition (OCR) of the isolated Roman characters.
Preparation of 4-substituted-bicyclo[2.2.1]heptane-1-carboxylic acids (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of 4-substituted-bicyclo[2.2.1]heptane-1-carboxylic acidsCharles F. Wilcox Jr. and Constance LeungCite this: J. Org. Chem. 1968, 33, 2, 877–880Publication Date (Print):February 1, 1968Publication History Published online1 May 2002Published inissue 1 February 1968https://pubs.acs.org/doi/10.1021/jo01266a099https://doi.org/10.1021/jo01266a099research-articleACS PublicationsRequest reuse permissionsArticle Views189Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The monoclonal antibody 7E <sub>12</sub> H <sub>12</sub> can differentiate primary adenocarcinoma of the bladder and prostate (1998)

The monoclonal antibody 7E12H12 can differentiate primary adenocarcinoma of the bladder from secondary adenocarcinoma arising in the prostate and may be a useful tool in diagnostic pathology.
Temporal Correlation Mapping Analysis of the Hemodynamic Penumbra in Mutant Mice Deficient in Endothelial Nitric Oxide Synthase Gene Expression (1996)

These data indicate that mice lacking eNOS expression show a greater degree of hemodynamic compromise after middle cerebral artery occlusion and suggest that a product of eNOS activity (eg. NO) may protect brain after focal cerebral ischemia, possibly by improving blood flow within the penumbral zone.
Fluctuation of serum complement levels in children with neuroblastoma (1979)

Serum samples from eleven children with neuroblastoma were drawn at diagnosis and again every 15 days or a month after the beginning of treatment over the course of 17 months observation. Twenty healthy children of the same age with no appreciable clinical manifestation were also studied as controls. Investigations included quantitative serum complement levels (total complement hemolytic activity, C3 and C4), anticomplementary serum activity and urine catecholamine levels (VMA and HVA). Complement levels of tumor patients were significantly higher than those of healthy subjects, but fluctuations were seen at different stages of the disease; patients at admission with active tumors or tumor recurrence had higher complement levels than those of patients in remission. Temporary recurrences of the disease were usually accompanied by fluctuations of urinary catecholamines, serum complement levels (mainly C3) and anticomplementary serum activity. At the terminal phase of the disease a drop in complement levels was usually seen, while urinary catecholamines were progressively increasing.
Quality-constrained routing in publish/subscribe systems (2005)

Routing in publish/subscribe (pub/sub) features a communication model where messages are not given explicit destination addresses, but destinations are determined by matching the subscription declared by subscribers. For a dynamic computing environment with applications that have quality demands, this is not sufficient. Routing decision should, in such environments, not only depend on the subscription predicate, but should also take the quality-constraints of applications and characteristics of network paths into account. We identified three abstraction levels of these quality constraints: functional, middleware and network. The main contribution of the paper is the concept of the integration of these constraints into the pub/sub routing. This is done by extending the syntax of pub/sub system and applying four generic, proposed by us, guidelines. The added values of quality-constrained routing concept are: message delivery satisfying quality demands of applications, improvement of system scalability and more optimise use of the network resources. We discuss the use case that shows the practical value of our concept.
Checking validity of topic maps with Drools (2010)

Topic map constraint language (TMCL) provides a means to impose the topic map conforming some constraints, which can be aligned with the ontology used in knowledge represent. In this paper a novel framework is proposed to validate the topic maps which maybe a subset of standard topic map model or extended model for some special application. At first, we develop a convenient tool to customize the constraint rules quickly with the simple syntax and intuitive semantics. Second, implement the processor for checking the validity and consistency of topic maps with Drools based pattern matching algorithm, improve reasoning efficiency by grouping and deleting rules, the algorithm is more powerful on semantic reasoning and suitable various special topic maps. At last, an extended topic map which provides more effective knowledge representation and navigation in e-learning education is used for experiment to estimate the presented method.