gebhart/patrepeval huggingface dataset:
Optimal Throughput Allocation in General Random-Access Networks (2006)

We consider a model for random-access communication in networks of arbitrary topology. We characterize the efficient (Pareto) boundary of the network throughput region as the family of solutions optimizing weighted proportional fairness objective, parameterized by link weights. Based on this characterization we propose a general distributed scheme that uses dynamic link weights to "move" the link-throughput allocation within the Pareto boundary to a desired point optimizing a specific objective. As a specific application of the general scheme, we propose an algorithm seeking to optimize weighted proportional fairness objective subject to minimum link-throughput constraints. We study asymptotic behavior of the algorithm and show that link throughputs converge to optimal values as long as link dynamic weights converge. Finally, we present simulation experiments that show good performance of the algorithm.
Immunoanatomic distribution of cytostructural and tissue-associated antigens in the human urinary tract. (1987)

The main objective of the present study is to define the expression and/or modulation of antigenic phenotypes in cells of the normal human kidney and urothelium according to cell type. Fourteen antibodies detecting differentiation and structural antigens expressed in the human urinary tract have been used to define the immunoanatomic distribution of these antigenic systems. They include urinary tract antigens (Tamm-Horsfall glycoprotein and prostate-specific antigen), tissue-associated antigens (epithelial membrane antigen, Factor VIII antigen, and Protein S-100), and cytoskeletal antigens of the intermediate filament classes (cytokeratins, vimentin, desmin, glial fibrillary acidic protein, and neurofilaments. Immunofluorescence and immunoperoxidase analyses performed on normal human fetal and adult tissue sections have demonstrated that these antigens are expressed by different cell types and domains of the nephron. Studies correlating normal fetal and adult tissues reveal that some of the antigens appear at distinct stages of maturation, representing early and late antigenic expression events. These antibodies offer a wide range of potential applications that include studies of embryogenesis of the human urinary tract and immunopathologic analyses of neoplastic and nonneoplastic diseases of the human kidney and urothelium.
PRODUCTION EXPERIENCE with BUILT-IN SELF-TEST in the IBM ES/9000 SYSTEM (2005)

This paper describes the performance of the Self-Test System used in the production of circuit modules for the new line of mainframes, the ES/9000 series. The system supports pseudorandom patterns generated and applied in a self-test mode from within the module, as well as control and pseudorandom stimuli and response compression through the IjO pins. Simulation-based diagnostics are used to generate repair actions to specific micro-nets, with an associated confidence level. Modules (containing roughly 500,000 gates) are being verified in under 3 minutes, with diagnosis of failing modules resulting in the isolation of a fault with 5 minutes of on-line time, followed by 11.7 minutes of off-line analysis.
Actin filaments are involved in the maintenance of Golgi cisternae morphology and intra‐Golgi pH (2006)

Here we examine the contribution of actin dynamics to the architecture and pH of the Golgi complex. To this end, we have used toxins that depolymerize (cytochalasin D, latrunculin B, mycalolide B, and Clostridium botulinum C2 toxin) or stabilize (jasplakinolide) filamentous actin. When various clonal cell lines were examined by epifluorescence microscopy, all of these actin toxins induced compaction of the Golgi complex. However, ultrastructural analysis by transmission electron microscopy and electron tomography/three-dimensional modelling of the Golgi complex showed that F-actin depolymerization first induces perforation/fragmentation and severe swelling of Golgi cisternae, which leads to a completely disorganized structure. In contrast, F-actin stabilization results only in cisternae perforation/fragmentation. Concomitantly to actin depolymerization-induced cisternae swelling and disorganization, the intra-Golgi pH significantly increased. Similar ultrastructural and Golgi pH alkalinization were observed in cells treated with the vacuolar H+ -ATPases inhibitors bafilomycin A1 and concanamycin A. Overall, these results suggest that actin filaments are implicated in the preservation of the flattened shape of Golgi cisternae. This maintenance seems to be mediated by the regulation of the state of F-actin assembly on the Golgi pH homeostasis.
Cell cycle‐regulated degradation of tmRNA is controlled by RNase R and SmpB (2005)

The production and removal of regulatory RNAs must be controlled to ensure proper physiological responses. SsrA RNA (tmRNA), a regulatory RNA conserved in all bacteria, is cell cycle regulated and is important for control of cell cycle progression in Caulobacter crescentus. We report that RNase R, a highly conserved 3' to 5' exoribonuclease, is required for the selective degradation of SsrA RNA in stalked cells. Purified RNase R degrades SsrA RNA in vitro, and is kinetically competent to account for all SsrA RNA turnover. SmpB, a tmRNA-binding protein, protects SsrA RNA from RNase R degradation in vitro, and the levels of SmpB protein during the cell cycle correlate with SsrA RNA stability. These results suggest that SmpB binding controls the timing of SsrA RNA degradation by RNase R. We propose a model for the regulated degradation of SsrA RNA in which RNase R degrades SsrA RNA from a non-tRNA-like 3' end, and SmpB specifically protects SsrA RNA from RNase R. This model explains the regulation of SsrA RNA in other bacteria, and suggests that a highly conserved regulatory mechanism controls SsrA activity.
Cancer invasion and metastasis: changing views (2007)

The formation of distant metastasis is the main cause of morbidity and mortality in patients with cancer. The aim of this article is to review recent advances in molecular and clinical aspects of metastasis. Traditionally, genes encoding extracellular matrix (ECM) processing proteases, adhesion proteins, and motility factors were thought to be amongst the main mediators of metastasis. Recently, however, genes activated during the early stages of tumourigenesis were implicated in the process. Conversely, genes thought to be primarily involved in metastasis such as urokinase plasminogen (uPA) and certain matrix metalloproteases (MMPs) are now known to also play a role in the early steps of tumour progression, perhaps by stimulating cell proliferation and/or promoting angiogenesis. Paradoxically, certain endogenous protease inhibitors such as PAI-1 and TIMP-1 appear to promote cancer metastasis rather than inhibiting the process. These recent advances in our understanding should lead to the development of new molecular markers for predicting the likely formation of metastasis as well as the identification of new targets for anti-metastatic therapies.
Architecture and Mobile IPv6 extensions supporting mobile networks in mobile communications (2002)

Mobile IPv6 supports packet routing for hosts moving on the Internet, but lacks support for networks moving on the Internet. For example, a network comprising a set of hosts and routers in a train can be a mobile network. While the mobile network is moving, a router in the network changes its point of connection to the Internet. This paper proposes an architecture and Mobile IPv6 extensions that support packet routing for mobile networks. The proposed scheme enables any host on a mobile network to communicate with any host connected to the Internet.
A Literature Review on the Health Status of Korean Workers under the Japanese Colonialism (1991)

The history of occupational health in Korea s covered the era of the Republic of Korea after the Liberation from the Japanese colonialism. But the number of Korean workers exceeded about 2 millions at the times of liberation in 1945, so that it is expected that many occupational health problems inflicted Korean workers under the Japanese colonialism. The authors reviewed medical literatures, administrative documents, and other available data which were published under the colonial state, and collected things which had reference to the health status of Korean workers. The results were as follows : 1. Nutritional status of Korean workers was supposed to be inferior to that of general population, some students, and poor inhabitants in a remote mountain villages. 2. It was supposed that the constitution of Korean workers was near lower limit of average build of contemporary Koreans. 3. The accidents rate in mines was significantly high but decreasing year after year, and the most important cause of accidents was the fall of roof in the mine. The medical facilities and equipments for miners were supposed to be not sufficient in the mines and workshops. 4. Some occupational disease including silicosis, noise-induced hearing impairment, and decompression disease were known. But, overall incidence or prevalence of these diseases could not be identified. 5. On the whole, the fatalities of acute infectious diseases of Korean workers were higher than those of Japanese inhabitants in Korea and Korean inhabitants. The prevalence of pulmonary tuberculosis of Korean workers was increasing with every passing year. 6. The medical personnels and facilities were so deficient that most Korean workers were out of adequate medical use. We discussed only a part of the health status of Korean workers under the Japanese colonialism, so it would be necessary to have a better grasp of details of occupational health policy and health status in the era of afflicting.
Acquired neuromyotonia: Evidence for autoantibodies directed against K<sup>+</sup>channels of peripheral nerves (1995)

Acquired neuromyotonia is characterized by hyperexcitability of motor nerves leading to muscle twitching, cramps, and weakness. The symptoms may improve following plasma exchange, and injection of immunoglobulin G (IgG) from 1 neuromyotonia patient into mice increased the resistance of neuromuscular transmission to d-tubocurarine. Here we examine nerves and muscle in vitro from mice injected with plasma or purified IgG from 6 neuromyotonia patients or pooled control subjects, and cultured dorsal root ganglion cells after treatment with IgG. Three of the patients had antibodies against human voltage-gated potassium channels labeled with 125I-alpha-dendrotoxin. The quantal release of acetylcholine (quantal content) at end-plates in diaphragms from mice treated with neuromyotonia IgG preparations was increased by 21% relative to control values (p = 0.0053). With one IgG preparation, the duration of the superficial peroneal nerve compound action currents was increased by 93%. The dorsal root ganglion cells treated with this IgG showed a marked increase in repetitive firing of action potentials. All effects were similar to those obtained with aminopyridines. We conclude that at least some patients with acquired neuromyotonia have antibodies directed against aminopyridine- or alpha-dendrotoxin-sensitive K+ channels in motor and sensory neurons, and they are likely to be implicated in the disease process.
Reranking search results for sparse queries (2011)

It is well known that clickthrough data can be used to improve the effectiveness of search results: broadly speaking, a query's past clicks are a predictor of future clicks on documents. However, when a new or unusual query appears, or when a system is not as widely used as a mainstream web search system, there may be little to no click data available to improve the results. Existing methods to boost query performance for sparse queries extend the query-document click relationship to more documents or queries, but require substantial clickthrough data from other queries. In this work we describe a way to boost rarely-clicked queries in a system where limited clickthrough data is available for all queries. We describe a probabilistic approach for carrying out that estimation and use it to rerank retrieved documents. We utilize information from co-click queries, subset queries, and synonym queries to estimate the clickthrough for a sparse query. Our experiments on a query log from a medical informatics company demonstrate that when overall clickthrough data is sparse, reranking search results using clickthrough information from related queries significantly outperforms reranking that employs clickthrough information from the query alone.
Piracetam in the Treatment of Acute Stroke (1999)

The neuroprotective properties of the nootropic agent piracetam together with reported hemorrheologic and antithrombotic effects provided the rationale for the evaluation of piracetam in acute stroke. Pilot studies showed an increase in compromised regional cerebral blood flow and improvement in motor function, aphasia and level of consciousness. Subsequently the Piracetam in Acute Stroke Study (PASS) was performed and the chief results have recently been reported (Stroke 28 (1997) 2347-2352). This was a multicenter double-blind trial in 927 patients to determine whether, compared with placebo, piracetam improved outcome when given within 12 hours of the onset of acute ischemic stroke, confirmed by computed tomography within 24 hours of admission (but not necessarily prior to treatment). Patients received an initial iv bolus of placebo or 12g piracetam, 12g piracetam daily for 4 weeks and maintenance treatment for a further 8 weeks. Neurologic status at 4 weeks was the primary end point; secondary outcome measures were functional outcome and aphasia at 12 weeks. Results in aphasic patients have not previously been reported. Analysis was planned both in all patients (n = 927) and an early treatment subgroup (n = 460) treated within 6 hours of stroke onset. This period was subsequently redefined as 7 hours. Intention-to-treat analyses in the total population showed a significant (P = 0.04) increase compared with placebo in the number of patients recovered from aphasia but no significant neurologic or functional improvement. Post hoc analysis in the early treatment subgroup showed improved neurologic outcome (P = 0.07), better function (P = 0.02) and a greater recovery rate from aphasia (P = 0.02). Additional analysis in this early treatment subgroup confined to 360 patients with moderate and severe stroke showed significant improvement in all 3 outcomes. There was no significant difference in mortality between treatment groups after 12 weeks. There were fewer deaths in piracetam-treated patients in those patients in the intention-to-treat population admitted with primary hemorrhagic stroke.
In Situ “Chainmail Catalyst” Assembly in Low‐Tortuosity, Hierarchical Carbon Frameworks for Efficient and Stable Hydrogen Generation (2018)

Abstract The chainmail catalysts (transition metals or metal alloys encapsulated in carbon) are regarded as stable and efficient electrocatalysts for hydrogen generation. However, the fabrication of chainmail catalysts usually involves complex chemical vapor deposition (CVD) or prolonged calcination in a furnace, and the slurry‐based electrode assembly of the chainmail catalysts often suffers from inferior mass transfer and an underutilized active surface. In this work, a freestanding wood‐based open carbon framework is designed embedded with nitrogen (N) doped, few‐graphene‐layer‐encapsulated nickel iron (NiFe) alloy nanoparticles (N‐C‐NiFe). 3D wood‐derived carbon framework with numerous open and low‐tortuosity lumens, which are decorated with carbon nanotubes (CNTs) “villi”, can facilitate electrolyte permeation and hydrogen gas removal. The chainmail catalysts of the N‐C‐NiFe are uniformly in situ assembled on the CNT “villi” using a rapid heat shock treatment. The high heating and quenching rates of the heat shock method lead to formation of the well‐dispersed ultrafine nanoparticles. The self‐supported wood‐based carbon framework decorated with the chainmail catalyst displays high electrocatalytic activity and superior cycling durability for hydrogen evolution. The unique heat shock method offers a promising strategy to rapidly synthesize well‐dispersed binary and polynary metallic nanoparticles in porous matrices for high‐efficiency electrochemical energy storage and conversion.
Development of Smart Bridge Bearings System - A Feasibility Study Project # C-02-02 (2005)

The goal of this project has been achieved through three tasks. The main goal of Task I has been to identify appropriate sensors that have potential for bridge bearings applications. This has been achieved through the following subtasks and has been presented in this chapter: (a) An extensive literature review of behavior of elastomeric bearings and state-of-the-art on the smart bearings; (b) Objective criteria for selection of sensors; (c) Information, specifications and reliability of commercially advanced sensors. The focus of Task II has been to develop possible instrumentation schemes for implementing smart bearings as presented in Chapter 2. In Task III, costs associated with feasibility of smart bearings have been investigated. This work has been reported in Chapter 3.
Dental Resins with Reduced Shrinkage During Hardening (1979)

Unsaturated spiro-orthocarbonates are monomers that expand on polymerization and will co-polymerize with conventional BIS-GMA based resins. This combination has good physical properties and bonding to enamel with some polymerization expansion evident at 50 C. Dispersion of the carbonate in microcrystalline form in liquid monomer appears to be a method to allow its reaction in the initial polymerization.
Herpes Simplex Virus Type 1 Immediate-Early Protein ICP22 Is Required for VICE Domain Formation during Productive Viral Infection (2009)

During productive infection, herpes simplex virus type 1 (HSV-1) induces the formation of discrete nuclear foci containing cellular chaperone proteins, proteasomal components, and ubiquitinated proteins. These structures are known as VICE domains and are hypothesized to play an important role in protein turnover and nuclear remodeling in HSV-1-infected cells. Here we show that VICE domain formation in Vero and other cells requires the HSV-1 immediate-early protein ICP22. Since ICP22 null mutants replicate efficiently in Vero cells despite being unable to induce VICE domain formation, it can be concluded that VICE domain formation is not essential for HSV-1 productive infection. However, our findings do not exclude the possibility that VICE domain formation is required for viral replication in cells that are nonpermissive for ICP22 mutants. Our studies also show that ICP22 itself localizes to VICE domains, suggesting that it could play a role in forming these structures. Consistent with this, we found that ICP22 expression in transfected cells is sufficient to reorganize the VICE domain component Hsc70 into nuclear inclusion bodies that resemble VICE domains. An N-terminal segment of ICP22, corresponding to residues 1 to 146, is critical for VICE domain formation in infected cells and Hsc70 reorganization in transfected cells. We previously found that this portion of the protein is dispensable for ICP22's effects on RNA polymerase II phosphorylation. Thus, ICP22 mediates two distinct regulatory activities that both modify important components of the host cell nucleus.
Reviews (1982)

Reviews Get access Joseph Addison: The Freeholder . Edited by JAMES LEHENY . Pp. xi£283 . Oxford : Clarendon Press , 1980 . £16.00. OLIVIA SMITH OLIVIA SMITH Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 29, Issue 1, February 1982, Pages 80–81, https://doi.org/10.1093/nq/29-1-80 Published: 01 February 1982
Therapy with OKT3 monoclonal antibody in refractory T cell acute lymphoblastic leukemia induces interleukin-2 responsiveness. (1995)

Administration of cytokines to patients with leukemia or lymphoma may recruit dormant malignant cells into cell cycle and thus make them more susceptible to chemotherapy. We treated a patient with refractory T cell acute lymphoblastic leukemia (ALL) with OKT3 monoclonal antibody and observed a dramatic but transient decrease of lymphoblasts. The T ALL cells were rather mature by morphology and immunophenotyping, expressing CD7, CD4, CD8 and CD3 surface antigens and nuclear TdT. Cytogenetic analysis revealed inversion of chromosome 14(q11q32.1). A total of 500 mg OKT3 (maximum dose 50 mg/day) was given. A decrease of lymphoblasts in the blood and a reduction of spleen size was observed. Complement levels dropped remarkably. Despite increasing serum levels of tumor necrosis factor, treatment was well tolerated overall. CD3 therapy induced strong IL-2 responsiveness of the lymphoblasts. Thus, OKT3 antibody treatment not only significantly decreased CD3-positive tumor cells, but also induced IL-2-mediated proliferation. This may also allow sequential application of CD3 and IL-2 to render certain T cell tumors more susceptible to chemotherapy.
Unsupervised Sequence Segmentation by a Mixture of Switching Variable Memory Markov Sources (2001)

We present a novel information theoretic algorithm for unsupervised segmentation of sequences into alternating Variable Memory Markov sources. The algorithm is based on competitive learning between Markov models, when implemented as Prediction Suffix Trees (Ron et al., 1996) using the MDL principle. By applying a model clustering procedure, based on rate distortion theory combined with deterministic annealing, we obtain a hierarchical segmentation of sequences between alternating Markov sources. The algorithm seems to be self regulated and automatically avoids over segmentation. The method is applied successfully to unsupervised segmentation of multilingual texts into languages where it is able to infer correctly both the number of languages and the language switching points. When applied to protein sequence families, we demonstrate the method&apos;s ability to identify biologically meaningful sub-sequences within the proteins, which correspond to important functional sub-units called domains.
Chemoselective reaction of formalin with 2‐(5‐substituted‐2‐hydroxybenzylamino)phenols: Synthesis of 6‐substituted 3‐(2‐hydroxyphenyl)‐3,4‐dihydro‐2<i>H</i>‐benzo[<i>e</i>][1,3]oxazines (2008)

Abstract magnified image Reaction of 2‐(5‐substituted‐2‐hydroxybenzylamino)phenols ( 2 ) with formalin in ethanol under reflux has chemoselectively led to 2‐(6‐substituted‐2 H —benzo[ e ][1,3]oxazin‐3(4 H )‐yl)phenols ( 3 ) in good yield involving the ring closure of the hydroxyl group of the C‐aryl ring and not that of the N‐aryl ring.
Cx43 and Dual-Pathway Electrophysiology of the Atrioventricular Node and Atrioventricular Nodal Reentry (2003)

Fluorescent imaging has revealed that posterior nodal extensions provide the anatomical substrate for the dual-pathway electrophysiology of the atrioventricular (AV) node during normal conduction and reentry. The reentry can be intranodal, or as well as the posterior nodal extensions, it can involve an endocardial layer of atrial/atrial-nodal (A/AN) cells as part of the AV nodal reentry (AVNR) circuit. Using fluorescent imaging with a voltage-sensitive dye and immunolabeling of Cx43, we mapped the electrical activity and structural substrate in 3 types of AVNR induced by premature atrial stimulation in 8 rabbit hearts. In 6 cases, the AVNR pathway involved (1) a fast pathway (FP), (2) the A/AN layer, and (3) a slow pathway (SP). In 4 cases, reentry took the path (1) SP, (2) A/AN layer, and (3) FP. In 2 cases, reentry was intranodal, propagating between the 2 posterior nodal extensions. Immunolabeling revealed that the FP and SP are formed by Cx43-expressing bundles surrounded by tissue without Cx43. Cx43-expressing posterior nodal extensions are the substrate of AVNR during both intranodal and extranodal reentry.