gebhart/patrepeval huggingface dataset:
Luminescent Nanocomposites Made of Finely Dispersed Y<sub>3</sub>Ga<sub>5</sub>O<sub>12</sub>:Tb Powder in a Polymer Matrix: Promising Candidates for Optical Devices (2012)

This paper reports the initial results of an original and simple method to elaborate flexible, self-standing, and thick luminescent films suitable for optical devices. PVP/Y(3)Ga(5)O(12):Tb(3+) nanocomposite films have been successfully achieved from a sol-gel derived Y(3)Ga(5)O(12):Tb(3+) powder and an alcoholic solution of poly-N-vinylpyrrolidone (PVP). The structural, morphological, and optical properties of these nanocomposite films have been studied and compared to those of a pristine PVP film and Y(3)Ga(5)O(12):Tb(3+) powder. The nanocomposite films were characterized by infrared and Raman spectroscopies as well as scanning and transmission electron microscopies (SEM and TEM) and demonstrated good dispersion of the phosphor particles within the polymer matrix via an alveolar mesostructure. The optical properties of these nanocomposites were fully characterized, and both their excitation and emission spectra and decay curves were recorded. Furthermore, photostability of the nanocomposite films and of the luminescent raw powder has been studied after exposure to an accelerated artificial photoageing at wavelengths higher than 300 nm. The elaboration process used is both tunable and applicable to a large variety of powders and polymers because it does not require any additive to form homogeneous and easily shapeable phosphor/polymer nanocomposites applicable in a large variety of optical devices such as solid-state-lighting.
Improvement of corrosion performance of 316L stainless steel via PVTMS/henna thin film (2012)

Metallic materials are the most used materials as orthopedic or dental implants due to their excellent mechanical properties. However they are not able to create a natural bonding with the mineralized bone and occasionally suffer localized corrosion. This work describes the electrochemical behavior of a hybrid sol–gel thin film with the addition of green inhibitor. These films enhance the ability of the implant to make a union with the existing bone and improve its resistance to aggressive environment. An ethanol solution of the polymerized vinyltrimethoxysilane (PVTMS) was mixed with an aqueous solution of henna extract (Lawsonia inermis) and refluxed to give homogeneous sols. Nanostructure hybrid PVTMS/henna thin films were deposited on the stainless steel 316L by spin-coating. The morphology, composition and adhesion of hybrid sol–gel coatings have been examined by SEM, EDX and pull-off test, respectively. Addition of high additive concentrations (0.1%) did not disorganize the sol–gel network. Direct pull-off test recorded a mean coating-substrate bonding strength larger than 20.6 MPa for the hybrid sol–gel coating. The effect of henna extract, with various added concentrations from 0.012% to 0.1%, on the anticorrosion properties of sol–gel films have been characterized by electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization tests in simulated body fluid (SBF) solution and has been compared to the bare metal. Henna extract additions (0.05%) have significantly increased the corrosion protection of the sol–gel thin film to higher than 90%. The in vitro bioactivity of prepared films indicates that hydroxyapatite nuclei can form and grow on the surface of the doped sol–gel thin films. The present study shows that due to their excellent anticorrosion properties, bioactivity and bonding strength to substrate, doped sol–gel thin films are practical hybrid films in biomedical applications.
Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3 (2018)

Summary: T helper 17 (Th17) cell development is programmed by the orphan nuclear receptor RORγt, but the underlying mechanism is not well understood. Nuclear receptor-mediated transcriptional activation depends on coactivators. Here, we show that steroid receptor coactivator-3 (SRC-3) critically regulates Th17 cell differentiation. Reduced incidence of experimental autoimmune encephalitis (EAE) associated with decreased Th17 cell generation in vivo was observed in mice with SRC-3 deletion specifically in T cells. In vitro, SRC-3 deficiency did not affect TGF-β/IL-6-induced Th17 cell generation but severely impaired pathogenic Th17 differentiation induced by IL-1/IL-6/IL-23. Microarray analysis revealed that SRC-3 not only regulates IL-17A but also IL-1R1 expression. SRC-3 bound to Il17a and Il1r1 loci in a RORγt-dependent manner and was required for recruitment of the p300 acetyltransferase. Thus, SRC-3 is critical for RORγt-dependent gene expression in Th17 cell-driven autoimmune diseases. : The unique transcriptional programs in IL-1-induced inflammatory Th17 cells have remained unclear. Tanaka et al. demonstrate that SRC-3 in CD4+ T helper cells functions as a specific coactivator of RORγt, a master transcription factor of Th17 cells, by regulating IL-1-IL1R1 signaling. Keywords: steroid receptor coactivator-3, pathogenic Th17, RORγt, EAE, IL1R1, IL17A, p300
Differential roles of IL-1 and TNF-α on graft-versus-host disease and graft versus leukemia (1999)

We demonstrate an increase in graft-versus-host disease (GVHD) after experimental bone marrow transplant (BMT) when cyclophosphamide (Cy) is added to an otherwise well-tolerated dose (900 cGy) of total body irradiation (TBI). Donor T cell expansion on day +13 was increased after conditioning with Cy/TBI compared with Cy or TBI alone, although cytotoxic T lymphocyte (CTL) function was not altered. Histological analysis of the gastrointestinal tract demonstrated synergistic damage by Cy/TBI and allogeneic donor cells, which permitted increased translocation of LPS into the systemic circulation. TNF-alpha and IL-1 production in response to LPS was increased in BMT recipients after Cy/TBI conditioning. Neutralization of IL-1 significantly reduced serum LPS levels and GVHD mortality, but it did not affect donor CTL activity. By contrast, neutralization of TNF-alpha did not prevent GVHD mortality but did impair CTL activity after BMT. When P815 leukemia cells were added to the bone marrow inoculum, allogeneic BMT recipients given the TNF-alpha inhibitor relapsed at a significantly faster rate than those given the IL-1 inhibitor. To confirm that the role of TNF-alpha in graft versus leukemia (GVL) was due to effects on donor T cells, cohorts of animals were transplanted with T cells from either wild-type mice or p55 TNF-alpha receptor-deficient mice. Recipients of TNF-alpha p55 receptor-deficient T cells demonstrated a significant impairment in donor CTL activity after BMT and an increased rate of leukemic relapse compared with recipients of wild-type T cells. These data highlight the importance of conditioning in GVHD pathophysiology, and demonstrate that TNF-alpha is critical to GVL mediated by donor T cells, whereas IL-1 is not.
An image self-verification scheme based on the rehash technique (2004)

Nowadays, images have become an important form of expression for data communication. However, if the images get tampered during the communication, their usefulness is undermined and the resending of images can bring unnecessary workload to network. Therefore, it is quite an important issue to maximize the usefulness of images even if the images have been tampered. To assure the authenticity and usefulness of images that have been tampered, this paper used modified Du et al.'s first level rehash to propose an image self-verification scheme. To increase the usefulness of tampered images, we manage to precisely identify which "pixels" of the tampered images have been tampered. The rightmost two bits of every pixel are used to store the authentication information, which was derived by means of the modified HIT construct procedure proposed in modified Du et al.'s (1983) first level rehash. Before sending images, both receiver and sender have to determine a secure key SK and several hash functions, and then the senders can calculate the HIT value first and embed the value to the rightmost two bits of every pixel to generate an image containing self-verification information. Upon receiving such images, the receivers can conduct the same procedure to calculate the HIT values for the authentication. As the authentication information is directly embedded in the images, no extra transmission cost will occur. Thus, our scheme will not increase transmission cost and is considerably convenient in real practice as there is no special limitation on the hash function used in our scheme.
Asymmetric Oxidative Coupling Polymerization of Optically Active Tetrahydroxybinaphthalene Derivative (2002)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTAsymmetric Oxidative Coupling Polymerization of Optically Active Tetrahydroxybinaphthalene DerivativeShigeki Habaue, Tomoaki Seko, and Yoshio OkamotoView Author Information Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan Cite this: Macromolecules 2002, 35, 7, 2437–2439Publication Date (Web):March 1, 2002Publication History Received22 October 2001Revised24 January 2002Published online1 March 2002Published inissue 1 March 2002https://pubs.acs.org/doi/10.1021/ma011828ohttps://doi.org/10.1021/ma011828orapid-communicationACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views527Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Monomers,Oxidative coupling,Polymerization,Polymers,Reaction products Get e-Alerts
Lifetime-based tomographic multiplexing (2010)

Near-infrared (NIR) fluorescence tomography of multiple fluorophores has previously been limited by the bandwidth of the NIR spectral regime and the broad emission spectra of most NIR fluorophores. We describe in vivo tomography of three spectrally overlapping fluorophores using fluorescence lifetime-based separation. Time-domain images are acquired using a voltage-gated, intensified charge-coupled device (CCD) in free-space transmission geometry with 750 nm Ti:sapphire laser excitation. Lifetime components are fit from the asymptotic portion of fluorescence decay curve and reconstructed separately with a lifetime-adjusted forward model. We use this system to test the in vivo lifetime multiplexing suitability of commercially available fluorophores, and demonstrate lifetime multiplexing in solution mixtures and in nude mice. All of the fluorophores tested exhibit nearly monoexponential decays, with narrow in vivo lifetime distributions suitable for lifetime multiplexing. Quantitative separation of two fluorophores with lifetimes of 1.1 and 1.37 ns is demonstrated for relative concentrations of 1:5. Finally, we demonstrate tomographic imaging of two and three fluorophores in nude mice with fluorophores that localize to distinct organ systems. This technique should be widely applicable to imaging multiple NIR fluorophores in 3-D.
3D DOPs for Positioning Applications Using Range Measurements (2011)

For terrestrial positioning, some applications require three dimensional coordinates. The Dilution of precisions (DOPs) for position systems using range measurement are reviewed and the average values of DOPs for different deployments of base station geometries are examined. It is shown that to obtain the lowest DOPs, the base stations for different types of positioning systems need to be deployed differently. Changing the N-sided regular polygon to an (N - 1)-sided polygon with one base station in the centre of the polygon can decrease the value of DOP in general for a pseudorange time of arrival (TOA) system but not for an absolute range TOA system. The height of the base station in the centre can also change the DOP significantly. The finding can be used to optimize the deployment of the base stations for range measurement positioning systems.
Motion correction and the use of motion covariates in multiple‐subject fMRI analysis (2006)

The impact of using motion estimates as covariates of no interest was examined in general linear modeling (GLM) of both block design and rapid event-related functional magnetic resonance imaging (fMRI) data. The purpose of motion correction is to identify and eliminate artifacts caused by task-correlated motion while maximizing sensitivity to true activations. To optimize this process, a combination of motion correction approaches was applied to data from 33 subjects performing both a block-design and an event-related fMRI experiment, including analysis: (1) without motion correction; (2) with motion correction alone; (3) with motion-corrected data and motion covariates included in the GLM; and (4) with non-motion-corrected data and motion covariates included in the GLM. Inclusion of covariates was found to be generally useful for increasing the sensitivity of GLM results in the analysis of event-related data. When motion parameters were included in the GLM for event-related data, it made little difference if motion correction was actually applied to the data. For the block design, inclusion of motion covariates had a deleterious impact on GLM sensitivity when even moderate correlation existed between motion and the experimental design. Based on these results, we present a general strategy for block designs, event-related designs, and hybrid designs to identify and eliminate probable motion artifacts while maximizing sensitivity to true activations.
Astrocyte glutamate transport: Review of properties, regulation, and physiological functions (2000)

Rapid removal of glutamate from the extracellular space is required for the survival and normal function of neurons. Although glutamate transporters are expressed by all CNS cell types, astrocytes are the cell type primarily responsible for glutamate uptake. Astrocyte glutamate uptake also plays a role in regulating the activity of glutamatergic synapses. Lastly, release of glutamate from astrocytes, via transporter reversal and other routes, can contribute to glutamate receptor activation. This review examines the mechanisms of astrocyte glutamate uptake and release, with particular focus on high-affinity Na(+)-dependent transporters. Transporter regulation, energetics, and physiological roles are discussed.
Acoustic rhinometry in humans: accuracy of nasal passage area estimates, and ability to quantify paranasal sinus volume and ostium size (2005)

A comprehensive study that compared acoustic rhinometry (AR) data to computed tomography (CT) data was performed to evaluate the accuracy of AR measurements in estimating nasal passage area and to assess its ability of quantifying paranasal sinus volume and ostium size in live humans. Twenty nasal passages of 10 healthy adults were examined by using AR and CT. Actual cross-sectional areas of the nasal cavity, sinus ostia sizes, and maxillary and frontal sinus volumes were determined from CT sections perpendicular to the curved acoustic axis of the nasal passage. Nasal cavity volume (from nostril to choana) calculated from the AR-derived area-distance curve was compared with that from the CT-derived area-distance curve. AR measurements were also done on pipe models that featured a side branch (Helmholtz resonator of constant volume but two different neck diameters) simulating a paranasal sinus. In the anterior nasal cavity, there was good agreement between the cross-sectional areas determined by AR and CT. However, posterior to the sinus ostia, AR overestimated cross-sectional area. The difference between AR nasal volume and CT nasal volume was much smaller than the combined volume of the maxillary and frontal sinuses. The results suggest that AR measurements of the healthy adult nasal cavity are reasonably accurate to the level of the paranasal sinus ostia. Beyond this point, AR overestimates cross-sectional area and provides no quantitative data for sinus volume or ostium size. The effects of paranasal sinuses and acoustic resonances in the nasal cavity are not accounted for in the present AR algorithms.
Artificial Neural Networks: Applications In Management (2013)

With the advancement of computer and communication technology, the tools used for management decisions have undergone a gigantic change. Finding the more effective solution and tools for managerial problems is one of the most important topics in the management studies today. Artificial Neural Networks (ANNs) are one of these tools that have become a critical component for business intelligence. The purpose of this article is to describe the basic behavior of neural networks as well as the works done in application of the same in management sciences and stimulate further research interests and efforts in the identified topics.
iRDM: A solution for workforce supply chain management in an outsourcing environment (2008)

Workforce is crucial to the success of service industry, especially for those software and consulting firms, where much of their revenue comes from the assignment of highly-skilled professionals. This is even more critical in the outsourcing environment, under which some of the professionals are outsourced from external vendors. Thus it is important to ensure hiring\assigning right people at the right time for the right project with the right cost. iRDM (intelligent Resource Deployment Manager) is an integrated solution developed by IBM Research division to support the full lifecycle management of highly-skilled professionals in the outsourcing environment. Based on the concept of "workforce supply chain", iRDM covers both the demand side and the supply side, and the matching between demand and supply. Besides the framework and software platform of iRDM, the demand and supply matching problem is mainly discussed. This solution has already been successfully deployed in an IBM consulting division.
Growth of Thick 4H–SiC(0001) Epilayers and Reduction of Basal Plane Dislocations (2005)

We investigate basal plane dislocations (BPDs) in thick 4H–SiC(0001) epilayers and the formation of stacking faults in the active region of pin diodes. Synchrotron reflection X-ray topography shows that epitaxial growth on (0001) is advantageous in preventing the propagation of BPDs from the substrate into the epilayer and obtaining a low BPD density in the epilayer compared with growth on (0001). The current stress test of 4H–SiC(0001) pin diodes demonstrates the suppressed formation of stacking faults.
Time‐dependent synergistic interactions between the vasodilator neuropeptide, calcitonin gene‐related peptide (CGRP) and mediators of inflammation (1991)

1. The action of the long lasting neuropeptide vasodilator, calcitonin gene-related peptide (CGRP), in potentiating oedema formation and neutrophil accumulation was investigated in the dorsal skin of the rabbit, in vivo. Combinations of agents under test were administered by intradermal (i.d.) injection. Oedema formation and neutrophil accumulation were then measured by quantitative radiolabel techniques. 2. CGRP (1 x 10(-11) mol per site) potentiated neutrophil accumulation induced by zymosan activated plasma, (used as a source of C5a des Arg), N-formyl-methionyl-leucyl-phenylalanine (FMLP) and leukotriene B4 (LTB4). In contrast CGRP did not induce neutrophil accumulation when injected alone. 3. Oedema formation induced by a series of chemically distinct mediators of increased microvascular permeability; bradykinin, platelet activating factor (PAF), FMLP and zymosan-activated plasma; measured 0-30 min after i.d. injection was potentiated by CGRP (1 x 10(-11) mol per site). 4. Oedema formation induced by zymosan activated plasma and FMLP but not bradykinin and PAF, was also significantly potentiated by CGRP when oedema was measured 30-60 min after i.d. injection. The potentiation of oedema induced by zymosan activated plasma measured 30-60 min after i.d. injection was not observed in the presence of the shorter acting prostanoid vasodilator prostacyclin (PGI2, 3 x 10(-10) mol per site). 5. These results suggest that CGRP, as a consequence of its sustained vasodilator activity could have prolonged potentiating effects on neutrophil accumulation and oedema formation in inflammatory conditions.
Profile of past and current clinical trials involving endothelin receptor antagonists: the novel "-sentan" class of drug. (2006)

Since its initial characterization in 1988, over 18,236 papers, including 2,485 reviews, have been published in the endothelin (ET) field. Over this period, several generations of selective and mixed (dual) ET receptor antagonists (ERAs), from peptidic backbones to orally active potent (subnanomolar) small molecular compounds, have been developed. These agents have been studied in many experimental animal models of various pathological conditions (cardiovascular, respiratory, and neuro-immunological). Continued basic research has led to a better understanding of the complex interactions between the ET axis and other biologic systems in human pathophysiology. The first clinical trial involved patients with idiopathic pulmonary arterial hypertension and led to approval of bosentan (Tracleer) for use in the United States and Europe in 2002. Since then, bosentan, the only currently approved dual (mixed) ERA, has been used in numerous other clinical trials. In addition, more selective ET(A) receptor antagonists (ambrisentan, atrasentan, avosentan, clazosentan, darusentan, and sitaxsentan) are undergoing clinical trials. Here we outline the ERAs undergoing development and summarize the standing of completed and ongoing trials at the time of the Ninth International Conference on Endothelin and even thereafter. This review is intended to provide a useful reference for those interested in the current state of clinical trials involving ERAs, and to identify lessons that might apply to the design of future trials.
Aloesin inhibits hyperpigmentation induced by UV radiation (2002)

Skin hyperpigmentation is caused by the overproduction of melanin pigment, which is synthesized by the action of tyrosinase. We recently reported that aloesin inhibits tyrosinase activity. The present study was undertaken to test the inhibitory effect of aloesin on pigmentation in human skin after UV radiation. Experimental subjects were UV-irradiated (210 mJ) on the inner forearm. UV-irradiated regions were assigned to four groups: vehicle control, aloesin treated, arbutin treated, and aloesin and arbutin treated. Aloesin and/or arbutin were administered four times a day for 15 days. Aloesin treatment suppressed pigmentation by 34%, arbutin by 43.5%, and the cotreatment by 63.3% compared with the control (n = 15; P < 0.05). Moreover, aloesin treatment showed pigmentation suppression in a dose-dependent manner (n = 7; P < 0.05). These results raise the possibility that aloesin may be used as an agent that inhibits melanin formation induced by UV radiation.