gebhart/patrepeval huggingface dataset:
Biophysical Responses upon the Interaction of Nanomaterials with Cellular Interfaces (2012)

The explosion of study of nanomaterials in biological applications (the nano-bio interface) can be ascribed to nanomaterials' growing importance in diagnostics, therapeutics, theranostics (therapeutic diagnostics), and targeted modulation of cellular processes. However, a growing number of critics have raised concerns over the potential risks of nanomaterials to human health and safety. It is essential to understand nanomaterials' potential toxicity before they are tested in humans. These risks are complicated to unravel, however, because of the complexity of cells and their nanoscale macromolecular components, which enable cells to sense and respond to environmental cues, including nanomaterials. In this Account, we explore these risks from the perspective of the biophysical interactions between nanomaterials and cells. Biophysical responses to the uptake of nanomaterials can include conformational changes in biomolecules like DNA and proteins, and changes to the cellular membrane and the cytoskeleton. Changes to the latter two, in particular, can induce changes in cell elasticity, morphology, motility, adhesion, and invasion. This Account reviews what is known about cells' biophysical responses to the uptake of the most widely studied and used nanoparticles, such as carbon-based, metal, metal-oxide, and semiconductor nanomaterials. We postulate that the biophysical structure impairment induced by nanomaterials is one of the key causes of nanotoxicity. The disruption of cellular structures is affected by the size, shape, and chemical composition of nanomaterials, which are also determining factors of nanotoxicity. Currently, popular nanotoxicity characterizations, such as the MTT and lactate dehydrogenase (LDH) assays, only provide end-point results through chemical reactions. Focusing on biophysical structural changes induced by nanomaterials, possibly in real-time, could deepen our understanding of the normal and altered states of subcellular structures and provide useful perspective on the mechanisms of nanotoxicity. We strongly believe that biophysical properties of cells can serve as novel and noninvasive markers to evaluate nanomaterials' effect at the nano-bio interface and their associated toxicity. Better understanding of the effects of nanomaterials on cell structures and functions could help identify the required preconditions for the safe use of nanomaterials in therapeutic applications.
Physical chemistry (Duffey, George H.) (1963)

ADVERTISEMENT RETURN TO ISSUEPREVBook and Media Revie...Book and Media ReviewNEXTPhysical chemistry (Duffey, George H.)Melvin W. Hanna Cite this: J. Chem. Educ. 1963, 40, 1, 52Publication Date (Print):January 1, 1963Publication History Received3 August 2009Published online1 January 1963Published inissue 1 January 1963https://doi.org/10.1021/ed040p52.2RIGHTS & PERMISSIONSArticle Views99Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
The Impact of Volume Phase Holographic Filters and Gratings on the Development of Raman Instrumentation (2007)

Volume phase holographic technology was originally developed and commercialized to produce holographic combiners for head-up displays (HUD) in fighter aircraft. By applying this technology to meet the needs of Raman spectroscopy three new optical components have been developed and incorporated into the latest generation of Raman instrumentation.
Effectiveness of Photocatalytic Filter for Removing Volatile Organic Compounds in the Heating, Ventilation, and Air Conditioning System (2006)

Nowadays, the heating, ventilation, and air conditioning (HVAC) system has been an important facility for maintaining indoor air quality. However, the primary function of typical HVAC systems is to control the temperature and humidity of the supply air. Most indoor air pollutants, such as volatile organic compounds (VOCs), cannot be removed by typical HVAC systems. Thus, some air handling units for removing VOCs should be added in typical HVAC systems. Among all of the air cleaning techniques used to remove indoor VOCs, photocatalytic oxidation is an attractive alternative technique for indoor air purification and deodorization. The objective of this research is to investigate the VOC removal efficiency of the photocatalytic filter in a HVAC system. Toluene and formaldehyde were chosen as the target pollutants. The experiments were conducted in a stainless steel chamber equipped with a simplified HVAC system. A mechanical filter coated with Degussa P25 titania photocatalyst and two commercial photocatalytic filters were used as the photocatalytic filters in this simplified HVAC system. The total air change rates were controlled at 0.5, 0.75, 1, 1.25, and 1.5 hr(-1), and the relative humidity (RH) was controlled at 30%, 50%, and 70%. The ultraviolet lamp used was a 4-W, ultraviolet-C (central wavelength at 254 nm) strip light bulb. The first-order decay constant of toluene and formaldehyde found in this study ranged from 0.381 to 1.01 hr(-1) under different total air change rates, from 0.34 to 0.433 hr(-1) under different RH, and from 0.381 to 0.433 hr(-1) for different photocatalytic filters.
Modulation of tau phosphorylation by environmental copper (2014)

We propose that reduction of brain copper by blocking uptake of copper from the diet may be a viable strategy for modulating tau pathology in Alzheimer's disease. The potential benefits of this approach are tempered by the absence of a behavioral benefit and by the health risks of excessive lowering of copper.
Delineation of two functional regions of transcription factor TFIIB. (1993)

Human transcription factor TFIIB, a protein of 316 amino acids, was subjected to limited proteolysis in order to define stable structural domains. We find that the C-terminal region of TFIIB, residues 106-316, is relatively stable, while the N-terminal region is very sensitive to proteases. Like full-length TFIIB, the stable domain, which we refer to as TFIIBc, interacts with the TATA-binding protein (TBP) on DNA. However, TFIIBc is unable to substitute for TFIIB in an in vitro transcription assay. We show by gel mobility-shift experiments that TFIIBc arrests formation of the transcription complex after binding to TBP, and we conclude that the N-terminal region of TFIIB, which is missing from TFIIBc, is responsible for the recruitment of RNA polymerase II to the promoter. We also show that TFIIBc inhibits transcription by competing with full-length TFIIB for the interaction with TBP, either in the presence or in the absence of the TBP-associated factors. The acidic transcriptional activator GAL4-VP16 does not favor the assembly of the functional transcription complex over the nonfunctional complex containing TFIIBc. Thus, if the function of GAL4-VP16 is enhancement of the interaction between TFIIB and the TFIID-DNA complex, then this function can also be exerted on the protease-resistant domain TFIIBc.
Transcription of the <i>Staphylococcus aureus cid</i> and <i>lrg</i> Murein Hydrolase Regulators Is Affected by Sigma Factor B (2004)

The Staphylococcus aureus lrg and cid loci are homologous operons that have been shown to regulate murein hydrolase activity and affect sensitivity to penicillin. Although the mode of action of these operons has not been demonstrated, a model based on the similarities of the lrgA and cidA gene products to the bacteriophage holin family of proteins has been proposed. In this study, the transcription organization and regulation of these operons were examined by Northern blot analyses. Unexpectedly, cidB and a gene located immediately downstream, designated cidC, were found to be cotranscribed on a 2.7-kb transcript. Maximal cidBC transcription occurred during early exponential growth, and high-level transcription of cidBC was dependent on the rsbU-mediated activation of the alternative sigma factor B (sigmaB). In contrast, lrgAB transcription in stationary phase was negatively regulated by sigmaB. Although cidABC transcription was not detected by Northern blot analysis, reverse transcriptase PCR revealed that these genes are also cotranscribed as a single RNA message in early exponential growth. Primer extension analysis revealed the presence of two cidBC transcription start sites, but no apparent sigmaB-dependent promoter consensus sequence was identified in these regions. The rsbU gene was also shown to have a positive impact on murein hydrolase activity but a negligible effect on sensitivity to penicillin-induced killing. These results suggest that the lrgAB and cidBC genes may be part of the S. aureus sigmaB-controlled stress regulon.
Effect of Pre-Chamber Volume and Nozzle Diameter on Pre-Chamber Ignition in Heavy Duty Natural Gas Engines (2015)

<div class="section abstract"><div class="htmlview paragraph">It has previously been shown by the authors that the pre-chamber ignition technique operating with fuel-rich pre-chamber combustion strategy is a very effective means of extending the lean limit of combustion with excess air in heavy duty natural gas engines in order to improve indicated efficiency and reduce emissions. This article presents a study of the influence of pre-chamber volume and nozzle diameter on the resultant ignition characteristics. The two parameters varied are the ratio of pre-chamber volume to engine's clearance volume and the ratio of total area of connecting nozzle to the pre-chamber volume. Each parameter is varied in 3 steps hence forming a 3 by 3 test matrix. The experiments are performed on a single cylinder 2L engine fitted with a custom made pre-chamber capable of spark ignition, fuel injection and pressure measurement. The measured main and pre-chamber pressure data is then used to perform heat release analysis to understand combustion phenomenon in pre-chamber and the ignition and combustion of fuel-lean charge in main chamber that follows. Within the span of parameter variation, it has been observed that a larger pre-chamber provides higher ignition energy which results in shortened flame development angle and combustion duration. It is also observed that at a given pre-chamber volume, nozzle diameter mainly affects the combustion duration which may be due to difference in penetration depths of pre-chamber jets. The varied parameters seemed to have minor effect on NOx emissions.</div></div>
Boric Acid Addition to Suppressive Antimicrobial Therapy for Recurrent Bacterial Vaginosis (2009)

Clinical experience with a triple phase maintenance regimen for women with RBV was encouraging but requires validation in a prospective randomized controlled study.
Some Fatigue Characteristics of Nickel Battery Plaque. (1978)

The conductance of sintered nickel battery plaque is experimentally determined as the plaque is being mechanically stressed. The plaque was subjected to bonding fatigue tests and to tensile testing. It was found that the plaque conductance exponentially decreases with bonding fatigue cycling. Also, it was determined that the plaque conductance is a function of its instantaneous state of stress. (Author)
Automatic Fraction Collector for Column Chromatography (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAutomatic Fraction Collector for Column ChromatographyO. G. Lien, Jr., E. A. Peterson, and D. M. GreenbergCite this: Anal. Chem. 1952, 24, 5, 920–921Publication Date (Print):May 1, 1952Publication History Published online1 May 2002Published inissue 1 May 1952https://pubs.acs.org/doi/10.1021/ac60065a053https://doi.org/10.1021/ac60065a053research-articleACS PublicationsRequest reuse permissionsArticle Views73Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of New Liner Technology for Application in Hot Stream Areas of Aero-engines (2004)

Conventional perforate acoustic liners are presently used in hot areas of aero-engines. The acoustic characteristics of these liners are extremely sensitive to flow and sound pressure level. Curren ...
Complexity Index From a Personalized Wearable Monitoring System for Assessing Remission in Mental Health (2014)

This study discusses a personalized wearable monitoring system, which provides information and communication technologies to patients with mental disorders and physicians managing such diseases. The system, hereinafter called the PSYCHE system, is mainly comprised of a comfortable t-shirt with embedded sensors, such as textile electrodes, to monitor electrocardiogram-heart rate variability (HRV) series, piezoresistive sensors for respiration activity, and triaxial accelerometers for activity recognition. Moreover, on the patient-side, the PSYCHE system uses a smartphone-based interactive platform for electronic mood agenda and clinical scale administration, whereas on the physician-side provides data visualization and support to clinical decision. The smartphone collects the physiological and behavioral data and sends the information out to a centralized server for further processing. In this study, we present experimental results gathered from ten bipolar patients, wearing the PSYCHE system, with severe symptoms who exhibited mood states among depression (DP), hypomania(HM), mixed state (MX), and euthymia (EU), i.e., the good affective balance. In analyzing more than 400 h of cardiovascular dynamics, we found that patients experiencing mood transitions from a pathological mood state (HM, DP, or MX-where depressive and hypomanic symptoms are simultaneously present) to EU can be characterized through a commonly used measure of entropy. In particular, the SampEn estimated on long-term HRV series increases according to the patients' clinical improvement. These results are in agreement with the current literature reporting on the complexity dynamics of physiological systems and provides a promising and viable support to clinical decision in order to improve the diagnosis and management of psychiatric disorders.
Event‐Related Potentials in Alcoholic Men: P3 Amplitude Reflects Family History But Not Alcohol Consumption (1991)

Multilead event-related potentials (ERPs), elicited by auditory and visual stimuli requiring a button press response and by a startling noise requiring no response, were recorded from male alcoholics and age-matched male controls (26-60 years old). Single-trial analyses of blink responses to the startling stimuli indicated that alcoholics startle less frequently but with equivalent amplitude as the controls. In contrast, single-trial analyses of P3 indicated that alcoholics generate a P3 as often as controls, but that their individual P3s are smaller. Alcoholics who reported a positive family history of problem drinking had larger startle blink amplitudes and smaller auditory and visual P3s than did alcoholics who reported a negative family history. Hierarchical regression analysis was used to demonstrate that smaller P3s in family history positive alcoholics were independent of lifetime alcohol consumption.
High Rate of HTLV-II Infection in Seropositive IV Drug Abusers in New Orleans (1989)

Confirmed infection with HTLV-II (human T cell leukemia virus type II) has been described only in rare cases. The major limitation to serological diagnosis of HTLV-II has been the difficulty of distinguishing HTLV-II from HTLV-I (human T cell leukemia virus type I) infection, because of substantial cross-reactivity between the viruses. A sensitive modification of the polymerase chain reaction method was used to provide unambiguous molecular evidence that a significant proportion of intravenous drug abusers are infected with HTLV, and the majority of these individuals are infected with HTLV-II rather than HTLV-I. Of 23 individuals confirmed by polymerase chain reaction analysis to be infected with HTLV, 21 were identified to be infected with HTLV-II, and 2 were infected with HTLV-I. Molecular identification of an HTLV-II--infected population provides an opportunity to investigate the pathogenicity of HTLV-II in humans.
In Vitro Activities of Two Antimitotic Compounds, Pancratistatin and 7-Deoxynarciclasine, against <i>Encephalitozoon intestinalis</i> , a Microsporidium Causing Infections in Humans (2001)

The antiparasitic effect of a collection of compounds with antimitotic activity has been tested on a mammalian cell line infected with Encephalitozoon intestinalis, a microsporidian causing intestinal and systemic infection in immunocompromised patients. The antiparasitic effect was evaluated by counting the number of parasitophorous vacuoles detected by immunofluorescence. Out of 526 compounds tested, 2 (pancratistatin and 7-deoxynarciclasine) inhibited the infection without affecting the host cell. The 50% inhibitory concentrations (IC(50)s) of pancratistatin and 7-deoxynarciclasine for E. intestinalis were 0.18 microM and 0.2 microM, respectively, approximately eightfold lower than the IC(50)s of these same compounds against the host cells. Electron microscopy confirmed the gradual decrease in the number of parasitophorous vacuoles and showed that of the two life cycle phases, sporogony was more sensitive to the inhibitors than merogony. Furthermore, the persistence of meronts in some cells apparently devoid of sporonts and spores indicated that the inhibitors block development rather than entry of the parasite into the host cell. The occurrence of binucleate sporoblasts and spores suggests that these inhibitors blocked a specific phase of cell division.
REWIND (2015)

Recent non-volatile memory (NVM) technologies, such as PCM, STT-MRAM and ReRAM, can act as both main memory and storage. This has led to research into NVM programming models, where persistent data structures remain in memory and are accessed directly through CPU loads and stores. Existing mechanisms for transactional updates are not appropriate in such a setting as they are optimized for block-based storage. We present REWIND, a user-mode library approach to managing transactional updates directly from user code written in an imperative general-purpose language. REWIND relies on a custom persistent in-memory data structure for the log that supports recoverable operations on itself. The scheme also employs a combination of non-temporal updates, persistent memory fences, and lightweight logging. Experimental results on synthetic transactional workloads and TPC-C show the overhead of REWIND compared to its non-recoverable equivalent to be within a factor of only 1.5 and 1.39 respectively. Moreover, REWIND outperforms state-of-the-art approaches for data structure recoverability as well as general purpose and NVM-aware DBMS-based recovery schemes by up to two orders of magnitude.
Reactivity of N-Heterocyclic Carbenes with [Ru<sub>3</sub>(CO)<sub>12</sub>] and [Os<sub>3</sub>(CO)<sub>12</sub>]. Influence of Ligand Volume and Electronic Effects (2007)

The room-temperature reactions of [Ru3(CO)12] and [Os3(CO)12] with a variety of N-heterocyclic carbenes (NHCs) have been studied. [Ru3(CO)12] reacts easily with N,N′-dimethylimidazol-2-ylidene (Me2Im), more slowly with N-methyloxazol-2-ylidene (MeOx), and very slowly with N,N′-dimesitylimidazol-2-ylidene (Mes2Im) to give the corresponding CO substitution products [Ru3(NHC)(CO)11], but it does not react with the very bulky N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (Dipph2Im). DFT calculations have shown that [Ru3(Dipph2Im)(CO)11] is a minimum in the corresponding potential energy surface; therefore, the absence of reaction between [Ru3(CO)12] and Dipph2Im has a kinetic origin associated with the large volume of this NHC. [Os3(CO)12] reacts with Me2Im to give [Os3(Me2Im)(CO)11]. However, MeOx is not basic enough and Mes2Im and Dipph2Im are too bulky to react with [Os3(CO)12], which is less reactive than [Ru3(CO)12]. Therefore, the reactions of [Ru3(CO)12] and [Os3(CO)12] with NHCs are strongly influenced by the electronic properties and steric demands of the NHCs and also by the intrinsic reactivity of the metal–carbonyls.
Steady-State Pharmacokinetics, Cord Blood Concentrations, and Safety of Ritonavir-Boosted Fosamprenavir in Pregnancy (2013)

Steady-state pharmacokinetics in pregnant women prescribed ritonavir-boosted fosamprenavir (FPV) to prevent HIV transmission were assessed in the second trimester, third trimester, and postpartum. Compared with postpartum, geometric mean amprenavir (APV, FPVs active metabolite) area under the plasma concentration-time curves were 35% lower in the second trimester and 25% lower in the third trimester. Maternal APV concentrations were 9- to 15-fold above the mean APV protein-adjusted 50% inhibitory concentration for wild-type HIV. Median ratio of cord blood/maternal APV levels was 0.27, and all infants were HIV negative. FPV/ritonavir during pregnancy was well tolerated and led to virologic suppression.