gebhart/patrepeval huggingface dataset:
Neural tube defects, choromosome abnormalities and multiple closure sites foe the human neural tube (1995)

The hypothesis that during human embryogenesis there is multi-site closure of the neural tube, with possibly regionally distinct genetic control, is examined in the light of the neural tube defects (NTD) observed in trisomy 13, trisomy 18 and triploidy which survive at least to the mid-trimester. In a series of mid-trimester fetuses examined post-mortem, there were two spina bifidas in 25 cases of trisomy 13; eight spina bifidas and one anencephalic among 38 trisomy 18 individuals; and three spina bifidas in 13 triploids. Not only was there a predominance of spina bifida, but all the spina bifidas were similar in location along the neuraxis: regardless of chromosome constitution, they were all sacral or lumbosacral. A survey of the literature confirms this finding. While this regionally distinct type of NTD is not specific to a particular chromosome abnormality and thus by implication to any particular gene, it does seem to be specific to an imbalance caused by an excess of genetic material of a type which permits survival past the first few post-conception weeks, and thus lends some support to the hypothesis.
Antiviral Activity of 3-Deazaguanine, 3-Deazaguanosine, and 3-Deazaguanylic Acid (1977)

3-Deazaguanine (ICN 4221), 3-deazaguanosine (ICN 4793), and 3-deazaguanylic acid (ICN 5412) represent a new class of synthetic guanine analogs having antiviral activity. In vitro, nine ribonucleic acid and seven deoxyribonucleic acid viruses were inhibited, including influenza, parainfluenza, rhino-, vesicular stomatitis, adeno-, herpes-, cytomegalo-, vaccinia, pseudorabies, and myxoma viruses. They were effective orally against influenza types A and B and parainfluenza type 1 (Sendai) virus infections in mice, with a therapeutic index of 16 against the latter two viruses. The course of herpes encephalitis was altered only when the drugs were applied directly into the brain. In addition, these drugs were effective inhibitors of Friend leukemia virus-induced splenomegaly in mice; treatment also produced extensions of life in these animals.
Morphological influences in the gas phase polymerization of ethylene by silica supported chromium oxide catalysts (1991)

Abstract Dramatic changes occur during the initial stages of olefin polymerization over heterogenous catalysts. As polymer accumulates, the catalyst fragments and the void space within the growing particle becomes filled with polymer. The changing monomer transport rate to the active sites, dissipation of heat and stress with the particle, and eventually, dispersion of catalyst fragments within the growing particle can control the polymerization. We focus on the changes in, and influence of, polymer, catalyst and void morphology during the nascent polymerization for silica supported chromium oxide catalysts. We find that the course of the polymerization depends on the initial stages yet is seldom considered in polymerization models. We review several years of morphological characterization that identify the important physical phenomena which occur during nascent heterogeneous olefin polymerization.
Overexpression of a 9 <i>-</i> cis-Epoxycarotenoid Dioxygenase Gene in <i>Nicotiana plumbaginifolia</i> Increases Abscisic Acid and Phaseic Acid Levels and Enhances Drought Tolerance (2002)

The plant hormone abscisic acid (ABA) plays important roles in seed maturation and dormancy and in adaptation to a variety of environmental stresses. An effort to engineer plants with elevated ABA levels and subsequent stress tolerance is focused on the genetic manipulation of the cleavage reaction. It has been shown in bean (Phaseolus vulgaris) that the gene encoding the cleavage enzyme (PvNCED1) is up-regulated by water stress, preceding accumulation of ABA. Transgenic wild tobacco (Nicotiana plumbaginifolia Viv.) plants were produced that overexpress the PvNCED1 gene either constitutively or in an inducible manner. The constitutive expression of PvNCED1 resulted in an increase in ABA and its catabolite, phaseic acid (PA). When the PvNCED1 gene was driven by the dexamethasone (DEX)-inducible promoter, a transient induction of PvNCED1 message and accumulation of ABA and PA were observed in different lines after application of DEX. Accumulation of ABA started to level off after 6 h, whereas the PA level continued to increase. In the presence of DEX, seeds from homozygous transgenic line TN1 showed a 4-d delay in germination. After spraying with DEX, the detached leaves from line TN1 had a drastic decrease in their water loss relative to control leaves. These plants also showed a marked increase in their tolerance to drought stress. These results indicate that it is possible to manipulate ABA levels in plants by overexpressing the key regulatory gene in ABA biosynthesis and that stress tolerance can be improved by increasing ABA levels.
Multifaceted Regioregular Oligo(thieno[3,4-<i>b</i>]thiophene)s Enabled by Tunable Quinoidization and Reduced Energy Band Gap (2015)

Thiophene-based materials have occupied a crucial position in the development of organic electronics. However, the energy band gaps of oligo- and polythiophenes are difficult to modulate without resorting to push-pull electronic effects. We describe herein a new series of monodisperse oligo(thieno[3,4-b]thiophene) derivatives with well-defined regioregular structures synthesized efficiently by direct C-H arylation. These compounds show a unique palette of colors and amphoteric redox properties with widely tunable energy band gaps. The capacity to stabilize both cations and anions results in both anodic and cathodic electrochromism. Under excitation, these compounds can produce photoionized states able to interconvert into neutral triplet or form these through singlet exciton fission or intersystem crossing. These features arise from a progressive increase in quinoidization on a fully planar platform making the largest effective conjugation length among hetero-oligomers. Oligo(thieno[3,4-b]thiophene)s might represent the more distinctive family of oligothiophenes of this decade.
Systemic Overexpression of IL-10 Induces CD4+CD25+ Cell Populations In Vivo and Ameliorates Type 1 Diabetes in Nonobese Diabetic Mice in a Dose-Dependent Fashion (2003)

Early systemic treatment of nonobese diabetic mice with high doses of recombinant adeno-associated virus (rAAV) vector expressing murine IL-10 prevents type 1 diabetes. To determine the therapeutic parameters and immunological mechanisms underlying this observation, female nonobese diabetic mice at 4, 8, and 12 wk of age were given a single i.m. injection of rAAV-murine IL-10 (10(4), 10(6), 10(8), and 10(9) infectious units (IU)), rAAV-vector expressing truncated murine IL-10 fragment (10(9) IU), or saline. Transduction with rAAV-IL-10 at 10(9) IU completely prevented diabetes in all animals injected at all time points, including, surprisingly, 12-wk-old animals. Treatment with 10(8) IU provided no protection in the 12-wk-old injected mice, partial prevention in 8-wk-old mice, and full protection in all animals injected at 4 wk of age. All other treatment groups developed diabetes at a similar rate. The rAAV-IL-10 therapy attenuated pancreatic insulitis, decreased MHC II expression on CD11b+ cells, increased the population of CD11b+ cells, and modulated insulin autoantibody production. Interestingly, rAAV-IL-10 therapy dramatically increased the percentage of CD4+CD25+ regulatory T cells. Adoptive transfer studies suggest that rAAV-IL-10 treatment alters the capacity of splenocytes to impart type 1 diabetes in recipient animals. This study indicates the potential for immunomodulatory gene therapy to prevent autoimmune diseases, including type 1 diabetes, and implicates IL-10 as a molecule capable of increasing the percentages of regulatory cells in vivo.
Spectrophotometric Retinal Oximetry in Pigs (2013)

Noninvasive spectrophotometric oximetry is sensitive to changes in oxygen saturation in pigs and correlated with intravitreal pO(2) measurements and with femoral artery pO(2). Pigs present a higher intraindividual variability in retinal oxygen saturation and a lower overall saturation than do humans. The difference between porcine and human eyes makes direct comparisons of measurements difficult.
Selective Deposition of Ultrathin Poly(<i>p</i>‐xylene) Films on Dielectrics Versus Copper Surfaces (2004)

Ultrathin films of poly( p ‐xylylene) are selectively deposited on oxide surfaces but not on air exposed copper . The polymers are deposited under conditions favorable for forming highly conformal ultrathin films appropriate for ‘pore sealing’ the surface of ultra‐low κ dielectrics. Variable angle spectroscopic ellipsometry is used to measure the polymer deposit on SiO 2 , and shows the lack of deposition on air‐exposed copper. X‐ray photoelectron spectroscopic analysis of the copper samples shows deposition of adventitious carbon on the metal surface, and confirms that no polymer deposition occurs.
Enhancement of Docetaxel Anticancer Activity by a Novel Diindolylmethane Compound in Human Non–Small Cell Lung Cancer (2009)

These findings suggest potential benefit for use of docetaxel and DIM-C-pPhC(6)H(5) combination in lung cancer treatment.
Bioresorbable ureteral stents from natural origin polymers (2014)

In this work, stents were produced from natural origin polysaccharides. Alginate, gellan gum, and a blend of these with gelatin were used to produce hollow tube (stents) following a combination of templated gelation and critical point carbon dioxide drying. Morphological analysis of the surface of the stents was carried out by scanning electron microscopy. Indwelling time, encrustation, and stability of the stents in artificial urine solution was carried out up to 60 days of immersion. In vitro studies carried out with simulated urine demonstrated that the tubes present a high fluid uptake ability, about 1000%. Despite this, the materials are able to maintain their shape and do not present an extensive swelling behavior. The bioresorption profile was observed to be highly dependent on the composition of the stent and it can be tuned. Complete dissolution of the materials may occur between 14 and 60 days. Additionally, no encrustation was observed within the tested timeframe. The ability to resist bacterial adherence was evaluated with Gram-positive Staphylococcus aureus and two Gram-negatives Escherichia coli DH5 alpha and Klebsiella oxytoca. For K. oxytoca, no differences were observed in comparison with a commercial stent (Biosoft(®) duo, Porges), although, for S. aureus all tested compositions had a higher inhibition of bacterial adhesion compared to the commercial stents. In case of E. coli, the addition of gelatin to the formulations reduced the bacterial adhesion in a highly significant manner compared to the commercial stents. The stents produced by the developed technology fulfill the requirements for ureteral stents and will contribute in the development of biocompatible and bioresorbable urinary stents.
Ultrasensitive two-site immunometric assay of human lutropin by time-resolved fluorometry (1990)

A rapid, sensitive two-site immunometric assay for human lutropin (LH), with two monoclonal antibodies directed against the beta subunit, has been developed with time-resolved fluorescence as the detection principle. The cross-reactivities with human thyrotropin and human follitropin are negligible and that with human choriogonadotropin is 1% in the standard two-step protocol. Free beta subunits of LH are also detected. Besides the standard procedure (45 + 15 min), more rapid alternative protocols (15 + 15 min or 30 min in one step) have also been evaluated. The minimum detectable dose per well is approximately 1 amol (10(-18) mol), corresponding to less than 0.01 int. unit/L, for a sample volume of 25 microL and less than 0.001 int. unit/L for 200-microL samples. The intra- and interassay CV is less than 6% for LH concentrations from 0.2 to 250 int. units/L. With 200-microL sample volumes, intra-assay variation is less than 6% at 0.04 int. unit/L and interassay variation is 7% at 0.05 int. unit/L. The very high sensitivity and reproducibility of the presented method enables assay of low prepubertal and of suppressed LH concentrations, and represents a clear improvement over currently available immunoassays.
Synthesis of Fluorinated Polythienothiophene-<i>co</i>-benzodithiophenes and Effect of Fluorination on the Photovoltaic Properties (2011)

Herein, we describe the synthesis of fluorinated polythienothiophene-co-benzodithiophenes (PTBFs) and the characterization of their physical properties, especially their performance in solar cells. Fluorination of the polymer backbone lowered both the HOMO and LUMO energy levels and simultaneously widened the energy bandgap of the polymer (0.1-0.2 eV). Incorporation of fluorine into the various positions of the polymer backbone significantly affected the solar cells' power conversion efficiency from 2.3% to 7.2%. Detailed studies revealed that the polymer containing mono-fluorinated thienothiophene gave the best solar cell performance. Perfluorination of the polymer backbone led to poor compatibility with PC(71)BM molecules, thus poor solar energy conversion efficiency. This is possibly due to the enhanced self-organization properties of the polymer chains and the fluorophobicity effect. Furthermore, it was found that perfluorination of the polymer backbone resulted in poor photochemical stability against singlet oxygen attack. Theoretical studies indicated that the internal polarization caused enhancement of the negative charge density on thienothiophene rings, which rendered them vulnerable to [2+4] cycloaddition reaction with singlet oxygen.
An improved algorithm for quantifier elimination over real closed fields (2002)

We give a new algorithm for quantifier elimination in the first order theory of real closed fields that improves the complexity of the best known algorithm for this problem till now. Unlike previously known algorithms the combinatorial part of the complexity of this new algorithm is independent of the number of free variables. Moreover, under the assumption that each polynomial in the input depend only on a constant number of the free variables, the algebraic part of the complexity can also be made independent of the number of free variables. This new feature of our algorithm allows us to obtain a new algorithm for a variant of the quantifier elimination problem. We give an almost optimal algorithm for this new problem, which we call the uniform quantifier elimination problem and apply it to solve a problem arising in the field of constraint databases. No algorithm with reasonable complexity bound was known for this latter problem till now. We also point out interesting logical consequences of this algorithmic result, concerning the expressive power of a constraint query language over the reals. Moreover, our improved algorithm for performing quantifier elimination immediately leads to improved algorithms for several problems for which quantifier elimination is a basic step, for example, the problem of computing the closure of a given semi-algebraic set.
Resilient Cluster-Organizing Key Management and Secure Routing Protocol for Mobile Ad Hoc Networks (2005)

Unlike traditional networks, the characteristics of mobile wireless devices that can dynamically form a network without any infrastructure and wired line mean that mobile ad hoc networks frequently display partition owing to node mobility or link failures. Consequently, an ad hoc network is difficult to provide on-line access to trusted authorities or centralized servers. Despite the existence of well-known security mechanisms, the absence of a stationary central authorization facility in an open and distributed communication environment is a major challenge. Consequently, applying traditional Public Key Infrastructure (PKI) security architecture to mobile ad hoc networks will create secure blind sides. Based on this perspective, this study proposes a novel scalable and robust cluster-organized key management scheme. Distribution of trust to an aggregation of cluster heads using a threshold scheme faculty provides mobile ad hoc networks with robust key management. Furthermore, the proposed approach provides Certificate Authority (CA) with a fault tolerance mechanism to prevent a single point of compromise or failure, and saves CA large repositories from maintaining member certificates, making the proposed approach more suitable for numerous mobile devices. Additionally, this study proposes a Cluster Secure Based Routing Protocol (CSBRP) to integrate into the key management to enhance non-repudiation of routing information and routing performances. Finally, this study introduces a mathematical model to demonstrate that the proposed cluster-based communication outperforms the node-based approach.
Transforming Growth Factor Beta Receptor 2 (TGFBR2) Changes Sialylation in the Microsatellite Unstable (MSI) Colorectal Cancer Cell Line HCT116 (2013)

Aberrant glycosylation is a common feature of many malignancies including colorectal cancers (CRCs). About 15% of CRC show the microsatellite instability (MSI) phenotype that is associated with a high frequency of biallelic frameshift mutations in the A10 coding mononucleotide microsatellite of the transforming growth factor beta receptor 2 (TGFBR2) gene. If and how impaired TGFBR2 signaling in MSI CRC cells affects cell surface glycan pattern is largely unexplored. Here, we used the TGFBR2-deficient MSI colon carcinoma cell line HCT116 as a model system. Stable clones conferring doxycycline (dox)-inducible expression of a single copy wildtype TGFBR2 transgene were generated by recombinase-mediated cassette exchange (RMCE). In two independent clones, dox-inducible expression of wildtype TGFBR2 protein and reconstitution of its signaling function was shown. Metabolic labeling experiments using the tritiated sialic acid precursor N-acetyl-D-mannosamine (ManNAc) revealed a significant decline (∼30%) of its incorporation into newly synthesized sialoglycoproteins in a TGFBR2-dependent manner. In particular, we detected a significant decrease of sialylated ß1-integrin upon reconstituted TGFBR2 signaling which did not influence ß1-integrin protein turnover. Notably, TGFBR2 reconstitution did not affect the transcript levels of any of the known human sialyltransferases when examined by real-time RT- PCR analysis. These results suggest that reconstituted TGFBR2 signaling in an isogenic MSI cell line model system can modulate sialylation of cell surface proteins like ß1-integrin. Moreover, our model system will be suitable to uncover the underlying molecular mechanisms of altered MSI tumor glycobiology.
A Rapid Two-Step Purification of Rat Liver Fetal Thymidine Kinase (1990)

Abstract The fetal isoenzyme of thymidine kinase was purified to apparent homogeneity from cytosols of rat fetuses liver. A two-step purification including anion exchange chromatography and affinity chromatography was developed. The purified enzyme appears as oligomeric with a relative molecular weight of 71 kDa. In denaturing media its molecular weight was 24 kDa, and its pHi 8.3.
A Porous Electrode for Oxidations or Reductions. (1925)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Porous Electrode for Oxidations or Reductions.Max KnobelCite this: Ind. Eng. Chem. 1925, 17, 8, 826Publication Date (Print):August 1, 1925Publication History Published online1 May 2002Published inissue 1 August 1925https://pubs.acs.org/doi/10.1021/ie50188a019https://doi.org/10.1021/ie50188a019research-articleACS PublicationsRequest reuse permissionsArticle Views29Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Using mobiles for on campus location tracking (2009)

The wide spread of mobiles as handheld devices would naturally lead to various innovative applications that makes use of their ever increasing presence in our daily life. One such application is location-tracking in indoor environments. In this paper we discuss the implementation of a simple and cost effective system that assists users in tracking colleagues and friends within a campus environment. The system uses the information built in a typical mobile such as its IMEI and IMSI and the various WiFi access points on campuses to pin point a user's position. A mobile application program communicates with a web server and a GSM modem to provide users with real time data related to a person's movements and location.
A polymer composite based organic FET multi-sensing device (2020)

Field-Effect Transistors (FETs) are the key building blocks in a wide range of electronic applications such as sensors and electrical switches. The emergence of Organic Field-Effect Transistors (OFETs) unveiled special features, which have taken the application of FETs into uncharted territories. These unique features include but are not limited to, low- cost processing, lightweight, mechanical flexibility, biocompatibility, broad material availability, etc. Similar to their inorganic counterparts, doping organic semiconductors (OSC) can significantly alter or improve their electrical and optoelectronic properties, resulting in doping induced OFET multi-functionalities. In this study, the impact of multi-doping on the OFET device performance and functionalities has been systematically investigated and evaluated under varying conditions of light, heat, and gate voltages. The experimental results appear to support the proposed hypothesis behind the multi-functionality of the system under study. The present work will provide valuable scientific insights for the advancement of OFET based sensors, switches, and modulators.
EAP Pre-authentication Problem Statement (2007)

EAP pre-authentication is defined as the utilization of EAP to pre-
establish EAP keying material on an authenticator prior to arrival of
the peer at the access network managed by that authenticator. This
draft discusses EAP pre-authentication problems in details.
Planar Polarimetry Receivers for Large Imaging Arrays at Q-band (2006)

The characterization of the intensity fluctuations of the cosmic microwave background (CMB) will be followed by the mapping of the polarization fluctuations of the CMB. Measurement of the polarization fluctuations requires highly sensitive instruments that are only possible by increasing the number of receivers. We are developing a large receiver array for the Q, U imaging experiment (QUIET) by building individual receivers that have noise temperatures close to the physical limit and that are simple, and low cost to build and operate. We developed these planar polarimetry receivers for Q-band by designing InP MMIC amplifiers with noise below 20 K, low loss and highly balanced phase switches and an entirely planar hybrid thin film circuit for the detection of the Stokes parameters Q and U. Our receivers achieve 25 K noise temperature over 8 GHz bandwidth and provide the I, Q and U parameters simultaneously. These planar modules have a simple plug in architecture that enables automated production of a large number of receivers and simple integration of large arrays of receivers