gebhart/patrepeval huggingface dataset:
An Enzyme-Linked Immunosorbent Assay for Quantitation of Aromatase Cytochrome P-450* (1989)

Traditionally, aromatase has been quantified as aromatase activity according to its ability to produce estrogen from androgen. We have developed a quantitative assay based on the protein mass of catalytically active aromatase cytochrome P-450. A solid phase sandwich enzyme-linked immunosorbent assay for aromatase cytochrome P-450 has been devised using mouse monoclonal antibody (MAb3-2C2) and rabbit polyclonal antiserum (PAb R-8-2). Two rabbit antisera (PAb R-8-1 and R-8-2) were raised by immunization against human placental aromatase cytochrome P-450 which had been isolated by immunoaffinity chromatography of MAb3-2C2-coupled to Sepharose 4B resin. Both antisera were capable of suppressing human placental aromatase activity with IC50 values of 0.6 and 0.8 microliter/ml incubate, respectively, and showed monospecific to aromatase cytochrome P-450 in the Western blot analyses. Solubilized human placental microsomal samples were incubated in microtiter wells precoated with MAb3-2C2. The unbound proteins were washed out, and the aromatase cytochrome P-450 bound with the MAb3-2C2 in the wells was then reacted with PAb R-8-2, the binding of which was subsequently probed with goat antirabbit immunoglobulin G antibody alkaline phosphatase conjugate. Immunoaffinity-purified aromatase cytochrome P-450 of human placental microsomes was used for the standard, with the current assay detection limit at 1 ng/ml. There was a positive correlation between aromatase activity and the immunoreactive aromatase cytochrome P-450 level in solubilized microsomal samples after preincubation at 22 and 37 C, indicating that the enzyme-linked immunosorbent assay measures the level of aromatase cytochrome P-450 that has catalytic activity. The mean level of aromatase cytochrome P-450 in solubilized human term placental microsomes was 16.4 +/- 10.3 (+/- SD) micrograms/ml, corresponding to 0.38 +/- 0.19% of the original microsomes. The mean specific activity of aromatization of the solubilized samples was 0.650 +/- 0.163 nmol estrogen formed/min.mg protein. These results indicate that aromatase in the solubilized placental microsomal fraction has catalytic ability of 5.3 +/- 1.6 min-1 based on the immunoassayable cytochrome P-450.
From Goal Oriented Requirements Specifications to Architectural Prescriptions (2001)

In the present thesis we propose a new method to design a high level\narchitecture of a software system that guarantees the satisfaction of its\nrequirements. We give an overview of the concepts of goal oriented\nrequirements specifications and of architectural prescriptions; we summarize the\ncharacteristics of KAOS, the goal oriented requirements specification language\nthat is used by our process, and we introduce Preskriptor, our Prescription\nSpecification Language (APL); we illustrate our methodology for transforming\nrequirements to an architectural prescription and provide practical examples;\nfinally, we discuss related work and indicate further directions of our research.
Digital Computer Solution of Electromagnetic Transients in Single-and Multiphase Networks (1969)

Electromagnetic transients in arbitrary single- or multiphase networks are solved by a nodal admittance matrix method. The formulation is based on the method of characteristics for distributed parameters and the trapezoidal rule of integration for lumped parameters. Optimally ordered triangular factorization with sparsity techniques is used in the solution. Examples and programming details illustrate the practicality of the method.
Comparative Evaluation of Vibrational Circular Dichroism and Optical Rotation for Determination of Enantiomeric Purity (2001)

Vibrational circular dichroism (VCD) is used to determine enantiomeric purity (EP) of three sample groups, and the results are compared with those obtained from optical rotation. In most typical cases EP determination from optical rotation is more accurate than that from VCD. However, in cases where either optical rotation is very small or different chiral samples are present as a mixture, EP determination from VCD provides definite advantages with reasonable accuracy.
Photorefractive Keratectomy for Hyperopia in 800 Eyes With the Meditec MEL 60 Laser (2001)

PRK with the Aesculap-Meditec MEL 60 scanning ArF excimer laser offered the best long-term results with +3.50 D or less preoperative refractive error. With higher corrections, regression, decrease in BSCVA, and daytime visual problems were encountered.
Evers, Medgar (1925–1963) (2009)

Medgar Wiley Evers typified the black grassroots leadership that made the civil rights movement of the 1950s and 1960s possible. He was born on July 2, 1925, in Decatur, Mississippi. In 1943, Evers dropped out of high school and, lying about his age, joined his older brother Charles in the United States Army. After serving a tour in Europe, he returned to Mississippi, finished high school, and enrolled in Alcorn College. Evers faced harsh opposition when he attempted to vote on his twenty‐first birthday; he and his brother were met with armed resistance at the courthouse. This episode, along with his experiences in college, strengthened Evers's desire to challenge Mississippi's segregated society.
The Bulk Heterojunction in Organic Photovoltaic, Photodetector, and Photocatalytic Applications (2020)

Organic semiconductors require an energetic offset in order to photogenerate free charge carriers efficiently, owing to their inability to effectively screen charges. This is vitally important in order to achieve high power conversion efficiencies in organic solar cells. Early heterojunction-based solar cells were limited to relatively modest efficiencies (<4%) owing to limitations such as poor exciton dissociation, limited photon harvesting, and high recombination losses. The development of the bulk heterojunction (BHJ) has significantly overcome these issues, resulting in dramatic improvements in organic photovoltaic performance, now exceeding 18% power conversion efficiencies. Here, the design and engineering strategies used to develop the optimal bulk heterojunction for solar-cell, photodetector, and photocatalytic applications are discussed. Additionally, the thermodynamic driving forces in the creation and stability of the bulk heterojunction are presented, along with underlying photophysics in these blends. Finally, new opportunities to apply the knowledge accrued from BHJ solar cells to generate free charges for use in promising new applications are discussed.
Influence of the Oral Administration of Lactic Acid Bacteria on Iga Producing Cells Associated to Bronchus (1999)

Intestinal, respiratory and genitourinary mucosal surfaces are the most important routes of entry for microbial pathogens. The stimulus of the mucosal immunity is not easy because the trigger keys for the activation do not follow the ones of the systemic immune response. In previous works we have demonstrated that some Lactic Acid Bacteria (LAB), when orally administered, can induce an enhance of the gut immune response. Taking into account the concept of a common mucosal response, we studied the effect of orally administered mice with Lactobacillus casei, L. acidophilus, L. rhamnosus, L. delbrueckii subsp. bulgaricus, Streptococcus salivarius subsp. thermophilus and Lactococcus lactis on the IgA secreting cells associated to bronchus. As shown before, oral immunostimulation with LAB induced an increase of the IgA* cells at intestinal level by a dose depending effect. In this study it is also showed that the LAB assayed, with exception of L. acidophilus, were able to enhance IgA+ cells at bronchial level, being also this effect dose dependent. The increment induced by some LAB in the number of IgA+ cells on the mucosa surface of the lower respiratory tract may be very important to prevent bronchus diseases.
Left Ventricular Thrombi and Cerebral Embolism (1989)

Cerebral embolism of cardiac origin is responsible for close to 15 percent of all cases of acute ischemic stroke — far fewer than the number attributed to thrombotic complications of cerebrovascular disease but still the source of catastrophic stroke in more than 75,000 North Americans per year.1 The destructive thrombi of cerebral embolism derive from a diverse array of cardiac diseases, about half of which involve atrial fibrillation and half, valvular heart disease or left ventricular mural thrombi.1 , 2 The cause of 60 percent of the emboli of left ventricular origin is acute myocardial infarction; the rest involve chronic ventricular dysfunction . . .
Risdiplam distributes and increases <scp>SMN</scp> protein in both the central nervous system and peripheral organs (2018)

Spinal muscular atrophy (SMA) is a rare, inherited neuromuscular disease caused by deletion and/or mutation of the Survival of Motor Neuron 1 (<i>SMN1)</i> gene. A second gene, <i>SMN2</i>, produces low levels of functional SMN protein that are insufficient to fully compensate for the lack of <i>SMN1</i>. Risdiplam (RG7916; RO7034067) is an orally administered, small-molecule <i>SMN2</i> pre-mRNA splicing modifier that distributes into the central nervous system (CNS) and peripheral tissues. To further explore risdiplam distribution, we assessed in vitro characteristics and in vivo drug levels and effect of risdiplam on SMN protein expression in different tissues in animal models. Total drug levels were similar in plasma, muscle, and brain of mice (n = 90), rats (n = 148), and monkeys (n = 24). As expected mechanistically based on its high passive permeability and not being a human multidrug resistance protein 1 substrate, risdiplam CSF levels reflected free compound concentration in plasma in monkeys. Tissue distribution remained unchanged when monkeys received risdiplam once daily for 39 weeks. A parallel dose-dependent increase in SMN protein levels was seen in CNS and peripheral tissues in two SMA mouse models dosed with risdiplam. These in vitro and in vivo preclinical data strongly suggest that functional SMN protein increases seen in patients' blood following risdiplam treatment should reflect similar increases in functional SMN protein in the CNS, muscle, and other peripheral tissues.
Brain Magnetic Resonance Imaging in Elderly Depressed Patients Receiving Electroconvulsive Therapy. (1989)

The authors review their experience with brain magnetic resonance (MR) imaging in elderly patients with depression referred for electroconvulsive therapy (ECT). A variety of brain changes were identified on the pre-ECT MR scans of these patients, including cortical atrophy, subcortical encephalomalacia, lateral ventricular enlargement, and lesions of the pons. The authors examine the effects of these preexisting brain changes on the therapeutic outcome and side effects from ECT. Pilot data suggest that these brain findings do not change during a course of ECT. The potential relationship of these brain changes to the development of affective disorder in the elderly is discussed and areas for future research are suggested.
Inheritance of Pod Detachment Force in Snap Beans, Phaseolus vulgaris L.1 (1976)

Abstract Pod detachment force (PDF) was measured at fresh market maturity (sieve size 4) for the parents, F 1 , F 2 , and both backcrosses for the cross ‘Harvester’ × ‘Idelight’. The distribution of the population means for the F 1 , F 2 , and backcrosses indicated strongly dominant gene effects were contributed by the ‘Harvester’ parent for high PDF. A minimum of 2 dominant genes controlled PDF and narrow sense heritability was estimated to be 61%.
Pharmacy Costs and Glycemic Control in the Department of Veterans Affairs (2004)

Diabetes was associated with high pharmacy costs. Increasing medication expenditures were associated with improved HbA(1c) levels at the aggregated national level. Policies concerning dispensing monitoring supplies and several diabetes quality improvement projects were initiated during this interval. Future challenges include initiatives to further optimize care while controlling costs.
Deep Photo Enhancer: Unpaired Learning for Image Enhancement from Photographs with GANs (2018)

This paper proposes an unpaired learning method for image enhancement. Given a set of photographs with the desired characteristics, the proposed method learns a photo enhancer which transforms an input image into an enhanced image with those characteristics. The method is based on the framework of two-way generative adversarial networks (GANs) with several improvements. First, we augment the U-Net with global features and show that it is more effective. The global U-Net acts as the generator in our GAN model. Second, we improve Wasserstein GAN (WGAN) with an adaptive weighting scheme. With this scheme, training converges faster and better, and is less sensitive to parameters than WGAN-GP. Finally, we propose to use individual batch normalization layers for generators in two-way GANs. It helps generators better adapt to their own input distributions. All together, they significantly improve the stability of GAN training for our application. Both quantitative and visual results show that the proposed method is effective for enhancing images.
Murine malaria: genetic control of resistance to Plasmodium chabaudi (1982)

Strain variation in the level of resistance to malaria was investigated in inbred strains of mice after infection with Plasmodium chabaudi. When infected intraperitoneally with 10(6) P. chabaudi-parasitized erythrocytes, mice of 11 inbred strains could be separated into two groups by using survival time as the criterion; C57BL/6J, C57L/J, DBA/2J, CBA/J, and B10.A/SgSn mice were found to be resistant to P. chabaudi, whereas A/J, DBA/1J, BALB/c, C3H/HeJ, AKR/J, and SJL/J mice were susceptible. An examination of F1 hybrids revealed that resistance was dominant over susceptibility. A segregation analysis of backcross and F2 progeny derived from susceptible A/J and resistant B10.A/SgSn parental mice suggested that host resistance in this strain combination was genetically controlled by a single, dominant, non-H-2-linked gene. Inheritance of resistance was autosomal, but expression of the trait was influenced by the sex of the host, female mice being more resistant than male mice. Phenotypic expression of the resistance gene was apparent within 6 days of infection as a significant difference between resistant and susceptible mice in the level of parasitemia. A preliminary analysis of the mechanism of resistance showed that compared with susceptible A/J mice, resistant B10.A/SgSn hosts had an augmented erythropoietic response during the course of malaria, as well as phenylhydrazine-induced anemia. These results suggest that the ability to replace destroyed erythrocytes quickly and efficiently may determine host survival after infection with P. chabaudi.
Margin requirements and futures activity: Evidence from the soybean and corn markets (1999)

This article investigates the impact of margin requirements on the trading activity and volatility in futures markets. We extend Hartzmark's (1986) model for futures demand to allow for the costs imposed by margins to change across the maturity of the contract. The model is tested employing data from the soybean and corn markets. We find that trading activity becomes more sensitive to margin changes as one gets closer to contract maturity, inconsistent with the notion that margins impose important opportunity costs on futures traders. Margins are found to have a negative impact on the trading activities of all types of traders, though there is some evidence that margin alterations bring about changes in the makeup of the market. The data also indicate that margins are likely to be hiked during periods of increased volatility, and reduced during periods of relative stability, thus suggesting that margin alterations serve primarily as insurance to futures exchanges. © 1999 John Wiley & Sons, Inc. Jrl Fut Mark 19: 433–455, 1999
Antimicrobial peptides from skin secretions of Rana esculenta. Molecular cloning of cDNAs encoding esculentin and brevinins and isolation of new active peptides. (1994)

Three cytolytic peptides, termed brevinin-1E, brevinin-2E, and esculentin, were isolated from skin secretions of the European frog Rana esculenta (Simmaco, M., Mignogna, G., Barra, D., and Bossa, F. (1993) FEBS Lett. 324, 159-161). Nucleotide sequence analysis of cDNAs coding for the corresponding precursors revealed that in all of them a single copy of the sequence of the mature peptide is present preceded by a dibasic cleavage site and followed by a stop codon. The signal peptides of these precursors show a clear homology to the corresponding region of the precursor of dermorphin, a neuropeptide occurring in the skin of amphibians of the subfamily Phyllomedusinae. Ten new peptides, ranging in size from 24 to 46 residues, all possessing an intramolecular disulfide bridge located at the carboxyl-terminal end, were isolated from skin secretions of R. esculenta. These peptides can be grouped into four subfamilies on the basis of their distinctive structural and/or functional properties. All of these new peptides have antimicrobial and/or hemolytic activities typical for the respective subfamily. In addition, we demonstrate that esculentin-1 also inhibits the growth of Pseudomonas aeruginosa, Candida albicans, and Saccharomyces cerevisiae.
The anonymous DNA probe p7-26 identifying the locus [D7S17] reveals an XmnI polymorphism (1989)

A 4.5kb single copy EcoRI fragment from the bacterio- phage 7-26 was subcloned into pBR322. The bacteriophage was isolated from a chromosome 7 specific library constructed in Charon 21A. POLYMORPHISM: XmnI (GAANN/NNTTC) identifies a two allele polymorphism with bands of 2.5kb (A) and 2.Okb (B). Three constant bands of 1.7, 1.3 and 0.6kb are observed.
Thermal and optical properties of living tissue: Application to laser‐induced hyperthermia (1985)

This report discusses the thermal distribution in living tissue during hyperthermic treatment with visible or infrared electromagnetic irradiation. The underlying physical mechanisms that determine the transient as well as the steady-state temperature distribution are discussed. Results from the treatment of a murine tumor model, C3H/Tif mammary adenocarcinoma in C3D2F1/Bom mouse strain, are reported. Total cure, defined by a nonrecurrent tumor, was obtained in 30% of the cases.
Nonlinear Calculations of the Time Evolution of Black Hole Accretion Disks (1994)

Based on previous works on black hole accretion disks, I continue to explore the disk dynamics using the finite difference method to solve the highly nonlinear problem of time-dependent alpha disk equations. Here a radially zoned model is used to develop a computational scheme in order to accommodate functional dependence of the viscosity parameter alpha on the disk scale height and/or surface density. This work is based on the author's previous work on the steady disk structure and the linear analysis of disk dynamics to try to apply to x-ray emissions from black candidates (i.e., multiple-state spectra, instabilities, QPO's, etc.).
Resonant Kondo scattering in Cu(Fe) thin film (1996)

The spin-flip rate of scattering resulting from the presence of Fe atoms in a very thin Cu film is determined as a function of the temperature between 1.6 K and 40 K by means of weak electron localization. The spin-flip scattering rate shows a maximum at 18 K which can be interpreted as resonant Kondo scattering. From a comparison of the Suhl - Nagaoka approximation with the present data a Kondo temperature is found.
Proximity Effects. XII. Reaction of cis- and trans-Cycloöctene Oxide with Bases (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProximity Effects. XII. Reaction of cis- and trans-Cycloöctene Oxide with BasesArthur C. Cope, Hiok-Huang Lee, and Harris E. PetreeCite this: J. Am. Chem. Soc. 1958, 80, 11, 2849–2852Publication Date (Print):June 1, 1958Publication History Published online1 May 2002Published inissue 1 June 1958https://doi.org/10.1021/ja01544a064RIGHTS & PERMISSIONSArticle Views289Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (569 KB) Get e-Alerts Get e-Alerts
On location McCarran international airport: air power (2003)

The Las Vegas airport has more than recouped its investment in common-use equipment, leading the way for other U.S. airports to eliminate proprietary airline systems that track flights, passengers and baggage.
An accurate method for computer‐generating tungsten anode x‐ray spectra from 30 to 140 kV (1997)

A tungsten anode spectral model using interpolating polynomials (TASMIP) was used to compute x-ray spectra at 1 keV intervals over the range from 30 kV to 140 kV. The TASMIP is not semi-empirical and uses no physical assumptions regarding x-ray production, but rather interpolates measured constant potential x-ray spectra published by Fewell et al. [Handbook of Computed Tomography X-ray Spectra (U.S. Government Printing Office, Washington, D.C., 1981)]. X-ray output measurements (mR/mAs measured at 1 m) were made on a calibrated constant potential generator in our laboratory from 50 kV to 124 kV, and with 0-5 mm added aluminum filtration. The Fewell spectra were slightly modified (numerically hardened) and normalized based on the attenuation and output characteristics of a constant potential generator and metal-insert x-ray tube in our laboratory. Then, using the modified Fewell spectra of different kVs, the photon fluence phi at each 1 keV energy bin (E) over energies from 10 keV to 140 keV was characterized using polynomial functions of the form phi (E) = a0[E] + a1[E] kV + a2[E] kV2 + ... + a(n)[E] kVn. A total of 131 polynomial functions were used to calculate accurate x-ray spectra, each function requiring between two and four terms. The resulting TASMIP algorithm produced x-ray spectra that match both the quality and quantity characteristics of the x-ray system in our laboratory. For photon fluences above 10% of the peak fluence in the spectrum, the average percent difference (and standard deviation) between the modified Fewell spectra and the TASMIP photon fluence was -1.43% (3.8%) for the 50 kV spectrum, -0.89% (1.37%) for the 70 kV spectrum, and for the 80, 90, 100, 110, 120, 130 and 140 kV spectra, the mean differences between spectra were all less than 0.20% and the standard deviations were less than approximately 1.1%. The model was also extended to include the effects of generator-induced kV ripple. Finally, the x-ray photon fluence in the units of photons/mm2 per mR was calculated as a function of HVL, kV, and ripple factor, for various (water-equivalent) patient thicknesses (0, 10, 20, and 30 cm). These values may be useful for computing the detective quantum efficiency, DQE(f), of x-ray detector systems. The TASMIP algorithm and ancillary data are made available on line at http:/(/)www.aip.org/epaps/epaps.html.