gebhart/patrepeval huggingface dataset:
From Washington (1989)

article Free Access Share on From Washington Author: Diane Crawford View Profile Authors Info & Claims Communications of the ACMVolume 32Issue 7July 1989pp 780–782https://doi.org/10.1145/65445.315972Published:01 July 1989Publication History 18citation214DownloadsMetricsTotal Citations18Total Downloads214Last 12 Months17Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Publisher SiteeReaderPDF
WORDSWORTH'S “PRELUDE” AND THE O.E.D.: WORD-COMBINATIONS (1964)

WORDSWORTH'S “PRELUDE” AND THE O.E.D.: WORD-COMBINATIONS Get access DUANE B. SCHNEIDER DUANE B. SCHNEIDER University of Colorado Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 11, Issue 3, March 1964, Pages 100-b–102, https://doi.org/10.1093/nq/11-3-100b Published: 01 March 1964
Alginate‐based and protein‐based materials for probiotics encapsulation: a review (2013)

Summary Owing to their considerable beneficial effects on human health, probiotics have been increasingly incorporated into food products. However, many findings have demonstrated that their survival and stability are very sensitive to processing and host gastrointestinal tract. To solve these problems, encapsulation techniques have been received considerable attention these days. So, in this review paper, methods for probiotics encapsulation, alginate‐based and protein‐based materials for probiotics encapsulation and application of encapsulated probiotics in food industry were discussed.
A Survey of Virginia State and County Governments (1928)

EARLY in I926, the general assembly of Virginia authorized Governor Byrd, at his request, to have a survey made of the state and county governments. The purpose of this survey was to furnish a factual basis for promoting the adoption of a plan of reorganization and consolidation, which the governor had roughly in mind at that time. It was Governor Byrd's idea that the services of an organization from outside the state should be secured to make the survey. After canvassing the agencies engaged in making such governmental studies, he selected the New York Bureau of Municipal Research. The Bureau's staff began work on the survey in May, I92.6, and finished in January, I917, at which time two reports, one on the state administration and one on the county governments, were completed. The actual field work, however, was concluded before the end of November. In conducting any governmental survey, the Bureau has found it both advisable and necessary to place one person in charge of the work. This individual is selected from the staff that actually takes part in the survey. He is made responsible for planning the broad outlines of the study, for the general direction of the field work, and for the editing and arrangement of the report. The Bureau, as you probably know, has long advocated individual responsibility in the conduct of public administration, as opposed to boards or commissions. This method merely applies the same idea to survey work; in other words, the Bureau takes its own medicine. In making the Virginia survey, the task of general supervision fell on me. Under the terms of our agreement with Governor Byrd, the scope of the survey was definitely marked out. It included the administrative departments, boards and institutions of the state government, and the entire organization of the county governments, the city governments being excluded from the study. Therefore, in planning the survey, the work naturally fell into two divisions, namely, state and county. A preliminary examination of the laws and the existing organization was made to determine the major functions in both the state administration and the county governments. On the basis of these functions, the work assignments were made to the different investigators taking part in the survey. These assignments were not clear cut in every instance; there was some overlapping between certain functions which could not be avoided. This, however, was readily handled by conferences between the in-
Optical detection and localization of holes in strips using a fluorescent fiber sensor (1990)

A noncontact sensor has been developed for detecting defects in thin-film sheet strips consisting of opacity variation, holes, cracks, and rendings or thickness variation of transparent film. It uses a fluorescent plastic optical fiber and a large luminescent source. A physical model has been developed and computer simulations have been performed in order to analyze the influence of all system parameters. Numerous experimental results are presented, and good agreement is observed with the theoretical model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Novel Mutations of the Endothelin B Receptor Gene in Patients with Hirschsprung's Disease and Their Characterization (1998)

Hirschsprung's disease (HSCR) is a congenital intestinal disease, characterized by the absence of ganglion cells in the distal portion of the intestinal tract. Recently, three susceptibility genes have been identified in HSCR, namely the RET protooncogene, the endothelin B (ET B ) receptor gene (EDNRB), and the endothelin-3 (ET-3) gene (EDN3). To investigate whether mutations in EDNRB could be related with HSCR in non-inbred populations in Japan, we examined alterations of the gene in 31 isolated patients. Three novel mutations were detected as follows: two transversions, A to T and C to A at nucleotides 311 (N104I) and 1170 (S390R), respectively, and a transition, T to C at nucleotide 325 (C109R). To analyze functions of these mutant receptors, they were expressed in Chinese hamster ovary cells. S390R mutation did not change the binding affinities but caused the decreases in the ligand-induced increment of intracellular calcium and in the inhibition of adenylyl cyclase activity, showing the impairment of the intracellular signaling. C109R receptors were proved to be localized near the nuclei as an unusual 44-kDa protein with the extremely low affinity to endothelin-1 (ET-1) and not to be translocated into the plasma membrane. On the other hand, N104I receptors showed almost the same binding affinities and functional properties as those of the wild type. Therefore, we conclude that S390R and C109R mutations could cause HSCR but that N104I mutation might be polymorphous.
Parameter Estimation of Time-Frequency Overlapped Signals Based on Cyclic Spectrum (2014)

A parameter estimation algorithm of time-frequency overlapped signals is presented based on cyclostationary of time-frequency signals.In the algorithm,the cyclic spectrum is calculated and the discrect spectrum-line is picked up making use of mathematic morphology,then modulation parameters are estimated,including carrier frequency and chip rate.The algorithm solves the problem of parameter pairs,and the use of mathematic morphology can reduce the background noise effectively.At the same time,the effect of the algorithm on the accuracy in the multipath fading Doppler effect channel is considered.The simulation proves that the algorithm is effective and accurate after overlapping BPSK and 8QAM,and it is robust to the noise with a high accuracy.
American Cancer Society guidelines for the early detection of cancer (2000)

This issue of CA inaugurates a yearly report on American Cancer Society guidelines for early detection of cancer in asymptomatic individuals. The current recommendations, which reflect almost 20 years of updates, cover screening recommendations for breast, colorectal, prostate, and cervical cancers, as well as for other cancers, depending on patient age, history, environmental and/or occupational exposures, etc. A key concept for both the general public and health providers is the distinction between public health recommendations regarding screening and decisions about early detection tests that might be undertaken on an individual basis. Although it is likely that current screening protocols will be supplanted by newer technologies, such as genetic and molecular markers of risk and disease, greater utilization of the technologies at hand will improve efforts toward establishing an organized and systematic approach to early cancer detection.
Direct synthesis of indole by the Fischer indole synthesis (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect synthesis of indole by the Fischer indole synthesisMasao Nakazaki and Koji YamamotoCite this: J. Org. Chem. 1976, 41, 10, 1877Publication Date (Print):May 1, 1976Publication History Published online1 May 2002Published inissue 1 May 1976https://pubs.acs.org/doi/10.1021/jo00872a045https://doi.org/10.1021/jo00872a045research-articleACS PublicationsRequest reuse permissionsArticle Views1065Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation. (1993)

In contrast to most cytokines, interleukin 4 (IL-4) expression is restricted to T lymphocytes, with the exception of mast cell lines and mast cells, as more recently demonstrated in rodents. Little is known, however, about the capacity of human nonlymphoid cells to produce IL-4. In this study we show that mature human basophils are capable of expressing IL-4 and examine the regulation of IL-4 production in comparison with the lipid mediator leukotriene C4. IL-4 was produced upon immunoglobulin E receptor (IgER) activation of basophils cultured with IL-3, a cytokine previously shown to prime these cells for enhanced release of inflammatory mediators. In some experiments, IL-3 or IgER activation alone also induced IL-4 production close to the detection limit. The effect of IL-3 on IgER-dependent IL-4 expression was dose and time dependent: maximal IL-4 production occurred between 18 and 48 h preexposure of basophils to 3-10 ng/ml IL-3. IgER-induced IL-4 synthesis and release by basophils cultured with IL-3 was rapid and complete after 6 h. In contrast to IL-3, other cytokines (IL-5, granulocyte/macrophage colony-stimulating factor, and nerve growth factor) that also prime basophils for enhanced histamine and leukotriene C4 release did not promote IgER-induced IL-4 synthesis. Basophils appear to secrete a "TH2-like" cytokine profile since no detectable IL-2 or interferon gamma was produced upon IgER activation. Mononuclear cells (depleted of basophils), cultured in parallel, did not release IL-4 in response to IL-3 and/or IgER activation, and produced approximately ten times less IL-4 than basophils upon nonspecific activation by phorbol ester and calcium ionophore. Thus, human basophils are an important cellular source of IL-4, and may, therefore, in addition to their inflammatory effector functions, also regulate the differentiation of T helper cells and B cells, in particular in allergic diseases.
Uricase and its action (1935)

Experimental methods. Preparation of uricase. Uricase was in some cases prepared according to the method described in Part vii [Truszkowski, 1934] (this will be termed Method I). The following procedure (Method II), which has the merits of economy of material, time and labour, was later adopted. The extracts are more highly coloured than are those of uricase prepared by the previous method, but for many purposes they serve equally well.
Data and voice integration in DR-TDMA for wireless ATM networks (2003)

This paper proposes data and voice scheduling algorithms for the dynamic reservation time division multiple access (DR-TDMA) MAC protocol for wireless ATM networks. Featuring a novel framed pseudo-Bayesian priority ALOHA algorithm that provides access priority to voice control packets, DR-TDMA improves the quality-of-service offered to voice connections and increases the maximum throughput for integrated voice and data traffic. The DR-TDMA protocol can also be extended to integrate constant bit rate (CBR) and variable bit rate (VBR) traffic in general. Simulation results show that the DR-TDMA protocol can achieve throughput in the range of 96% while maintaining reasonable quality of service for data traffic and a voice loss rate lower than 1%.
Metalorganic Chemical Vapor Deposition of Thin Film ZrO<sub>2</sub>and Pb(Zr,Ti)O<sub>3</sub>: Precursor Chemistry and Process Characteristics (2002)

Metalorganic chemical vapor deposition (MOCVD) process characteristics of several zirconium source reagents were investigated. These source reagents included metal β-diketonates [e.g., Zr(thd)4 where thd=(2,2,6,6-tetramethyl-3,5-heptanedionate)] and metal alkoxide/β-diketonates [e.g., Zr(OiPr)2(thd)2 and Zr(OtBu)2(thd)2]. Thermal properties and transport behaviors of these precursors were examined by thermogravimetric analysis. Zirconium oxide films were deposited on silicon substrates at reduced pressure. Under the process conditions examined, the deposition behavior was mass-transport controlled, and Zr(OiPr)2(thd)2 and Zr(OtBu)2(thd)2 behaved similarly. The films exhibited low carbon content. Pb(Zr, Ti)O3 (PZT) films were deposited on iridium-coated silicon substrates under reduced pressure. Zirconium incorporation efficiency was significantly improved for Zr(OiPr)2(thd)2 when compared to Zr(thd)4. Use of M(OtBu)2(thd)2 (where M=Zr or Ti) as source reagents for MOCVD of PZT was examined and compared to M(OiPr)2(thd)2 analogues. In this case, higher process pressures were needed to improve the incorporation efficiencies of M(OtBu)2(thd)2 precursors.
Assembly of the cytolytic alternative pathway of complement from 11 isolated plasma proteins. (1978)

The known cytolytic function of the alternative pathway in serum was quantitatively reproduced by combining 11 isolated plasma proteins at their respective serum concentrations. These proteins are: C3, Factor B, Factor D, C3b inactivator, beta1H, native properdin, C5, C6, C7, C8, and C9. In absence of activators of the alternative pathway, this mixture was stable at 37 degrees C as evidenced by lack of consumption of Factor B, C3, and C5. Upon addition of either rabbit erythrocytes or neuraminidase-treated sheep erythrocytes, cell lysis ensued and the extent of lysis was dependent on dose of the component mixture. The dose-response curves obtained with the isolated component mixture and with C4-depleted serum were virtually indistinguishable. Nonactivator erythrocytes (untreated sheep erythrocytes) were not lysed by the component mixture. Deletion of properdin resulted only in a twofold diminution of the hemolytic activity of the component mixture. No immunoglobulin requirement was apparent. These results indicate that the cytolytic systems studied are internally sufficient and capable of coupling the initiation and amplification sequence with the cytolytic membrane attack sequence.
Differential Time Course of Cytochrome P450 2D6 Enzyme Inhibition by Fluoxetine, Sertraline, and Paroxetine in Healthy Volunteers (2002)

The selective serotonin reuptake inhibitors (SSRIs) paroxetine, sertraline, and fluoxetine have varying degrees of potency in inhibiting the hepatic cytochrome P450 (CYP) 2D6 enzyme. However, the time course for maximum inhibition to occur or for inhibition to dissipate when dosing is discontinued, requires clarification. In an open label, parallel group study of 45 healthy volunteers, the time course of CYP2D6 inhibition of the above SSRIs was evaluated. Subjects were randomized to receive paroxetine at 20 mg/day for 10 days; sertraline at 50 mg/day for 3 days, followed by sertraline at 100 mg/day for 10 days; or fluoxetine at 20 mg/day for 28 days. CYP2D6 activity was assessed using the dextromethorphan metabolic ratio (DMR) on antidepressant days 5 and 10 for sertraline and paroxetine and at weekly intervals for fluoxetine. Following SSRI discontinuation, calculation of a CYP2D6 inhibition half-life (t(1/2)inh) revealed the time course of fluoxetine inhibition (t(1/2)inh = 7.0 +/- 1.5 days) to be significantly longer than either paroxetine (t(1/2)inh = 2.9 +/- 1.9) or sertraline (t(1/2)inh = 3.0 +/- 3.0) (p < 0.01), but the latter were not significantly different from each other (p > 0.05). Time for the extrapolated DMR versus time log-linear plots to return to baseline was significantly different between fluoxetine (63.2 +/- 5.6 days) and both paroxetine (20.3 +/- 6.4 days) and sertraline (25.0 +/- 11.0 days) (p < 0.01), making the rank order (from longest to shortest) of time for CYP2D6 inhibition to dissipate: fluoxetine > sertraline >or= paroxetine. Differences between mean baseline DMR values and measured values obtained after drug discontinuation for each drug group became nonsignificant on discontinuation day 5 for both paroxetine and sertraline and on discontinuation day 42 for fluoxetine. These data define the time course of a persistent effect that fluoxetine, sertraline, and paroxetine have on CYP2D6 following drug discontinuation and should be considered when initiating therapy with a CYP2D6 substrate.
A wave effect enabling universal frequency scaling, monostatic passive radar, incoherent aperture synthesis, and general immunity to jamming and interference (2008)

A fundamental Doppler-like but asymmetric wave effect that shifts received signals in frequency in proportion to their respective source distances, was recently described as means for a whole new generation of communication technology using angle and distance, potentially replacing TDM, FDM or CDMA, for multiplexing. It is equivalent to wave packet compression by scaling of time at the receiver, converting path-dependent phase into distance-dependent shifts, and can multiply the capacity of physical channels. The effect was hitherto unsuspected in physics, appears to be responsible for both the cosmological acceleration and the Pioneer 10/11 anomaly, and is exhibited in audio data. This paper discusses how it may be exploited for instant, passive ranging of signal sources, for verification, rescue and navigation; incoherent aperture synthesis for smaller, yet more accurate radars; universal immunity to jamming or interference; and precision frequency scaling of radiant energy in general.
Noninvasive monitoring of cerebral blood oxygenation in ovine superior sagittal sinus with novel multi-wavelength optoacoustic system (2009)

Noninvasive monitoring of cerebral blood oxygenation with an optoacoustic technique offers advantages over current invasive and noninvasive methods. We report the results of in vivo studies in the sheep superior sagittal sinus (SSS), a large central cerebral vein. We changed blood oxygenation by increasing and decreasing the inspired fraction of oxygen (FiO(2)). Optoacoustic measurements from the SSS were performed at wavelengths of 700, 800, and 1064 nm using an optical parametric oscillator as a source of pulsed near-infrared light. Actual oxygenation of SSS blood was measured with a CO-Oximeter in blood samples drawn from the SSS through a small craniotomy. The amplitude of the optoacoustic signal induced in the SSS blood at lambda = 1064 nm closely followed the changes in blood oxygenation, at lambda = 800 nm was almost constant, and at lambda = 700 nm was changing in the opposite direction, all in accordance with the absorption spectra of oxy- and deoxyhemoglobin. The optoacoustically predicted oxygenation correlated well with actual blood oxygenation in sheep SSS (R(2) = 0.965 to 0.990). The accuracy was excellent, with a mean difference of 4.8% to 9.3% and a standard deviation of 2.8% to 4.2%. To the best of our knowledge, this paper reports for the first time accurate measurements of cerebral venous blood oxygenation validated against the "gold standard" CO-Oximetry method.
Influence of Temperature and Humidity on the Life History of the Spider Agelena Naevia Walckenaer1 (1941)

There have been but few studies of spider life histories; most of the work on these animals has been taxonomic and morphological. The Peckhams (1890), Fabre (1919), Peters (1931–1937) and others have studied various phases of spider behavior, and Savory (1928) summarized the work done on spiders. The writer has found no records of studies on the effect of temperature and humidity upon spiders. The present paper attempts to show the influence of these physical factors upon the early stages of Agelena naevia Walckenaer.
Broad-Spectrum Antiviral Activity of Nucleic Acid-Based Antiviral Agents Against Avian and Seasonal Influenza Viruses (2008)

The increasing prevalence of influenza viruses resistant to antiviral drugs such as amantadine and oseltamivir undermines our ability to defend against future influenza pandemics. There is an urgent need to develop novel antiviral agents which are robust and offer broad-spectrum protection against the ever changing influenza viruses. The objective of this study is to evaluate the in vivo antiviral efficacy nucleic acid-based immunomodulators such as Poly ICLC (synthetic ds RNA) and oligonucleotides containing unmethylated CpG using a mouse lethal infection model with influenza A/PR/8/34 (H1N1) and/or with the highly pathogenic avian influenza H5N1 (HPAI) viruses. Groups of BALB/c mice were pre-treated intranasally with 1 or 2 doses of liposome-encapsulated Poly ICLC (LE-Poly ICLC, 20 μg/dose/mouse) or with CpG (5 μg/dose/mouse) oligonucleotides. At various times post pre-treatment, the animals were challenged intranasally with multiple doses of influenza A/PR/8/34 or with HPAI viruses, and survival rates of control and pre-treated mice were compared at day 14 post infection. Pre-treatment with liposome-encapsulated Poly ICLC provided complete protection against 10 LD50 influenzaA/PR/8/34 and 1 LD50 dose of HPIA virus. When the challenge dose of HPIA was increased to 4 LD50, the protection provided by LE-Poly ICLC was 63–75% (p < 0.001 vs control), with all control mice succumbed to the infection. Pre-treatment with CpG oligonucleotides provided complete protection to mice against 5 LD50 influenza A/PR/8/34. The window of protection (the time interval between drug pretreatment and virus challenge) was 21 days for LE-Poly ICLC and 4 days for CpG oligonucleotides, respectively. RT-PCR analyses of mouse lung tissues from LE-Poly ICLC treated mice showed activation of toll-like receptor-3 pathway, and induction of cytokines including IL 1-α, -β, IFN-γ, TNF-α, among others. Collectively, these results suggest that LE-Poly ICLC can provide broad-spectrum protection and may have an important role in protecting against avian or seasonal influenza infections.
iTEM: a chip-level electromigration reliability diagnosis tool using electrothermal timing simulation (1996)

In this paper, we present a new electromigration reliability diagnosis tool (iTEM) for CMOS VLSI circuits. Unlike previous electromigration reliability tools, iTEM can estimate the interconnect temperature rise due to joule heating and heat conduction from the substrate using a newly developed lumped thermal model. Including the temperature effect, iTEM provides more accurate electromigration reliability diagnosis. Moreover, it is very fast and can analyze circuit layouts containing tens of thousands of transistors on a desktop workstation.