gebhart/patrepeval huggingface dataset:
Immunoinhibition assay of the serum activity of human glycogen isophosphorylase BB in the diagnosis of the acute myocardial ischaemia. (1987)

Polyclonal rabbit anti-human isophosphorylases inhibit selectively the isoenzyme activities of the BB and MM isoenzyme of the human glycogen phosphorylase b with high sensitivity and without crossreactivities. On this basis a serological immunoinhibition assay of the BB isoenzyme in the range of 1-125 nmol s-1 l-1 is described. Preliminary clinical results indicate the BB isoenzyme as a sensitive and specific marker of the acute myocardial ischaemia including bypass surgery and suggest a substantial improvement of the differential diagnosis of infarction.
Polymerization from the Surface of Single-Walled Carbon Nanotubes − Preparation and Characterization of Nanocomposites (2003)

Single-walled carbon nanotubes were functionalized along their sidewalls with phenol groups using the 1,3-dipolar cycloaddition reaction. These phenols could be further derivatized with 2-bromoisobutyryl bromide, resulting in the attachment of atom transfer radical polymerization initiators to the sidewalls of the nanotubes. These initiators were found to be active in the polymerization of methyl methacrylate and tert-butyl acrylate from the surface of the nanotubes. However, the polymerizations were not controlled, leading to the production of high molecular weight polymers with relatively large polydispersities. The resulting polymerized nanotubes were analyzed by IR, Raman spectroscopy, DSC, TEM, and AFM. The nanotubes functionalized with poly(methyl methacrylate) were found to be insoluble, while those functionalized with poly(tert-butyl acrylate) were soluble in a variety of organic solvents. The tert-butyl groups of these appended polymers could also be removed to produce nanotubes functionalized with poly(acrylic acid), resulting in structures that are soluble in aqueous solutions.
X-Ray Induced Polymerization of Gaseous Vinyl Chloride. Effect of Additives (1971)

The X-ray induced polymerization in the gas phase of pure vinyl chloride and of its mixtures with O 2 , NO, SF 6 , NH 3 , CH 3 NH 2 , H 2 O, HCl, and C 2 H 2 were examined. About 75% of the polymerization proceeds via a radical mechanism. The experiments indicate that most of the additives are deactivating chain transfer agents. Gel permeation chromatography showed that the polymer is activated by X-ray absorption during the time it takes to fall to the bottom of the irradiation cell, and forms a branched polymer.
Stationary foreground detection using background subtraction and temporal difference in video surveillance (2010)

In this paper we describe a new algorithm focused on obtaining stationary foreground regions, which is useful for applications like the detection of abandoned/stolen objects and parked vehicles. Firstly, a sub-sampling scheme based on background subtraction techniques is implemented to obtain stationary foreground regions. Secondly, some modifications are introduced on this base algorithm with the purpose of reducing the amount of stationary foreground detected. Finally, we evaluate the proposed algorithm and compare results with the base algorithm using video surveillance sequences from PETS 2006, PETS 2007 and I-LIDS for AVSS 2007 datasets. Experimental results show that the proposed algorithm increases the detection of stationary foreground regions as compared to the base algorithm.
Successful haploidentical mismatched bone marrow transplantation in severe combined immunodeficiency: T cell removal using CAMPATH‐I monoclonal antibody and E‐rosetting (1986)

Six patients with severe combined immunodeficiency were transplanted with bone marrow from their HLA haploidentical parents. T-lymphocytes were removed by complement mediated lysis with a monoclonal antibody (CAMPATH-I) followed by rosetting with sheep erythrocytes. The patients were pre-conditioned with marrow ablative chemotherapy, using busulphan and cyclophosphamide. There was graft take in five patients, with evidence of transient acute graft-versus-host disease only. Three patients are alive and well greater than 5 months after transplant, and one who is 12 months post graft has full reconstitution of cell mediated and humoral immunity, including specific antibody response to immunization. Transplantation across major histocompatibility barriers can be successfully achieved using this method of treatment of donor marrow.
Angular and Temporal Correlation of V2X Channels across Sub-6 GHz and mmWave Bands (2018)

5G millimeter wave (mmWave) technology is envisioned to be an integral part of next- generation vehicle-to-everything (V2X) networks and autonomous vehicles due to its broad bandwidth, wide field of view sensing, and precise localization capabilities. The reliability of mmWave links may be compromised due to difficulties in beam alignment for mobile channels and due to blocking effects between a mmWave transmitter and a receiver. To address such challenges, out-of-band information from sub-6 GHz channels can be utilized for predicting the temporal and angular channel characteristics in mmWave bands, which necessitates a good understanding of how propagation characteristics are coupled across different bands. In this paper, we use ray tracing simulations to characterize the angular and temporal correlation across a wide range of propagation frequencies for V2X channels ranging from 900 MHz up to 73 GHz, for a vehicle maintaining line-of-sight (LOS) and non-LOS (NLOS) beams with a transmitter in an urban environment. Our results shed light on increasing sparsity behavior of propagation channels with increasing frequency and highlight the strong temporal/angular correlation among 5.9 GHz and 28 GHz bands especially for LOS channels.
Implication of Transforming Growth Factor–β1 in Chagas Disease Myocardiopathy (2002)

Cardiac dysfunction with progressive fibrosis is a hallmark of Chagas disease. To evaluate the involvement of transforming growth factor (TGF)-beta1 in this disease, TGF-beta1 levels in patients were measured at 3 stages: asymptomatic indeterminate (IND), cardiac with no or slight heart dysfunction (Card 1), and cardiac with moderate or severe heart dysfunction (Card 2). All patients had significantly higher circulating levels of TGF-beta1 than did healthy persons, and 27% of patients in the Card 1 group had higher TGF-beta1 levels than did patients in the IND group. Immunohistochemical analysis of cardiac biopsy specimens showed strong fibronectin staining in the extracellular matrix and staining for phosphorylated Smad 2 (activation of the TGF-beta1 signaling pathway) in cell nuclei. The higher levels of latent TGF-beta1 observed in patients with myocardiopathy, together with intracellular activation of the TGF-beta1 pathway and tissue fibrosis, suggest that TGF-beta1 plays an important role in Chagas disease. TGF-beta1 may represent a new target for preventive and curative treatments of Chagas disease.
Sparse Winograd Convolutional Neural Networks on Small-scale Systolic Arrays (2019)

The reconfigurability, energy-efficiency, and massive parallelism on FPGAs make them one of the best choices for implementing efficient deep learning accelerators. However, state-of-art implementations seldom consider the balance between high throughput of computation power and the ability of the memory subsystem to support it. In this paper, we implement a framework on FPGA by combining the sparse Winograd convolution, clusters of small-scale systolic arrays, and a tailored recursive Z-Morton memory layout design. We also provide an analytical model analysis for the general Winograd convolution algorithm as a design reference. Experimental results on various CNN models show that it achieves very high computation resource utilization, 20x~30x energy efficiency, and more than 5x speedup compared with the dense implementation.
Treatment of progressive supranuclear palsy and corticobasal degeneration (2005)

Success in treating patients with progressive supranuclear palsy and corticobasal degeneration remains exceedingly low. This finding probably relates to the widespread distribution of the pathological changes that account for the varied and complex spectrum of clinical manifestations. Dopaminergic drugs are regularly used for the parkinsonian features; however, these rarely result in more than modest benefit, and when better or sustained responses are obtained, as sometimes occurs in progressive supranuclear palsy, the clinical features are atypical and diagnosis is often delayed or not made in life. A variety of other treatments have been used in both disorders, sometimes directed at other specific features such as dystonia or myoclonus, and these treatments will be reviewed. Greater success in treating these disorders will require advances in our understanding of their cause(s) or the pathogenetic mechanisms underlying the neurodegenerative processes. The similarities in the molecular pathology of these four-repeat tauopathies suggests that important advances in the management of one will have a definite impact on the treatment of the other. © 2005 Movement Disorder Society
Fin line with a variable characteristic (1980)

This paper presents a new fin-line structure whose characteristics can be varied by placement of an additional dielectric substrate adjacent to the fin structure. A rigorous analysis is given from which the dispersion and characteristic impedance are computed. This structure should find extensive application in the design of fin-line phase-shifters and filters at millimeter-wave frequencies.
Template-directed inorganic crystallization: oriented nucleation of barium sulfate under Langmuir monolayers of an aliphatic long chain phosphonate (1992)

Compressed Langmuir monolayers of an aliphatic long chain (C<sub>20</sub>) phosphonate were shown to influence the morphology and crystallographic orientation of barium sulfate nucleated from the aqueous subphase. The crystals were aligned with the [100] crystallographic axis perpendicular to the plane of the monolayer indicating that nucleation occurred on the (100) face. The majority of these oriented crystals exhibited a rhombic habit during the initial stages of crystallization. These subsequently developed into platelike or 'bow-tie' morphologies depending upon the growth mechanism under the monomolecular film. Occasionally, small polar laths oriented along the [100] axis were observed. For each of these crystal forms, nucleation on the (100) face and their subsequent development can be rationalized in terms of specific electrostatic, geometric and stereochemical interactions at the organic/inorganic interface.
In situ self-assembly of peptides in glucan particles for macrophage-targeted oral delivery (2014)

In this study, an orally administered macrophage-targeting peptide delivery system was constructed through in situ self-assembly of Q11 peptide inside hollow glucan particles (GPs), which are approved by the FDA. The glucan shell efficiently protected the encapsulated peptide from enzymatic degradation in the gastrointestinal tract. β-1,3-(d)-Glucan is recognized by the membrane receptor dectin-1, which is highly expressed by intestinal antigen-presenting cells, including macrophages. GPs are thus efficiently phagocytized by intestinal macrophages. This study is applicable to the pharmaceutical industry for the development of orally delivered macrophage-targeting systems for effective and personalized remedies like immunotherapeutic vaccines.
Effect of antioxidant supplementation on urine and blood markers of oxidative stress during extended moderate-altitude training (1999)

The results of this study suggest that work in a moderate-altitude cold-weather environment is accompanied by increased oxidative stress, despite relatively high intakes of dietary and supplemental antioxidants.
A Simple Method for Determining the Green's Function for a Large Class of MIC Lines Having Multilayered Dielectric Structures (1978)

To find the characteristic parameters of the wave propagation in microstrip structures, several Green's function methods have already been developed, corresponding to particular geometric configurations. In this paper, three of these methods are synthesized, showing that the final equations in the different cases are identical. Moreover, using the transverse transmission line theory, the Green's function is solved numerically for an N-layer dielectric structure.
Subclinical keratoconus and inflammatory molecules from tears (2009)

IL-6 and TNF-alpha are overexpressed in the tears of subclinical and KC eyes. Increased MMP-9 levels were found only in the KC eye. These results indicate that the pathogenesis of KC may involve chronic inflammatory events.
Effects of carbon concentration on high-hardness plasma-polymer-fluorocarbon film deposited by mid-range frequency sputtering (2019)

We propose a method for fabricating high-hardness plasma-polymer-fluorocarbon (PPFC) thin films with controllable optical and surface properties via manipulation of the target composition design and sputtering power density. The carbon/polytetrafluoroethylene (PTFE) composite polymeric material targets with the low electrical resistance were prepared by press-molding using a mechanically mixed powder of PTFE, carbon nanotubes, and graphite. The composite targets showed electrical sheet resistances of 0.1-100 Ω/sq. PPFC thin films were deposited by mid-range frequency (MF) sputtering at power densities within 0.62~4.92 W/cm<sup>2</sup>. The maximum surface hardness of the PPFC thin film was 4.75 GPa, which was 21.6 times higher than that of fluorocarbon thin film sputtered from PTFE under the same conditions. With the increase of the carbon concentration in the target, the carbon cross-linking density of the PPFC thin film increased but the fluorine concentration decreased. The concentration of fluorine in the PPFC thin films grew with increasing sputtering power density. The MF sputtered carbon-rich PPFC thin films are controllable with physical properties of optical transmittance, surface hardness and surface water repellency which could be applied as protective layers for transparent flexible devices.
Salmeterol, a long‐acting β<sub>2</sub>‐adrenoceptor agonist mediating cyclic AMP accumulation in a neuronal cell line (1993)

1. The accumulation of cyclic AMP stimulated by salmeterol, a long-acting beta 2-adrenoceptor agonist and by isoprenaline, a non-selective beta-adrenoceptor agonist have been compared in the B50 neuroblastoma cell line. 2. Salmeterol produced a concentration-dependent increase in the accumulation of total [3H]-cyclic AMP in B50 cells yielding an EC50 value of 37 nM which was lower than that obtained with isoprenaline (294 nM). The maximum response to salmeterol was only 46% of that obtained with isoprenaline. 3. The beta 2-adrenoceptor antagonist, ICI 118551, inhibited the responses to both salmeterol (apparent KD 2.2 nM) and isoprenaline (apparent KD 1.6 nM). However, the beta 1-adrenoceptor antagonist, atenolol, produced no significant effect at concentrations up to 100 microM. 4. Salmeterol (1 microM) changed the concentration-response curve of isoprenaline in the manner of a partial agonist interacting with a full agonist. The KD of salmeterol obtained from the interaction was 55.6 nM. 5. Whereas salmeterol has a slow onset of action in airway smooth muscle compared to other beta 2-adrenoceptor agonists, in B50 monolayers both salmeterol and isoprenaline produced a rapid increase in cyclic AMP accumulation (t1/2 1.1 min and 0.4 min respectively). 6. Despite the existence of cyclic AMP efflux mechanisms that exist in this cell line it was possible to investigate the duration of agonist action by measuring intracellular levels of the second messenger. Replacement of drug-containing medium with fresh buffer led to a rapid reduction in intracellular levels of cyclic AMP in isoprenaline-stimulated cells whereas cyclic AMP accumulation was sustained for much longer periods in salmeterol-stimulated cells. However, the persistent action of salmeterol could be reversed by the addition of a beta2-selective antagonist.7. These results confirm that salmeterol has a high affinity, but low efficacy (relative to isoprenaline) for beta2-adrenoceptors coupled to cyclic AMP accumulation and that the drug persists at its site of action for long periods in the B50 neuronal cell line.
[Morphological inversions during the ontogenesis of the ixodid ticks (Acari: Ixodidae) from the viewpoint of the hypermorphosis conception and their significance for systematics]. (2006)

Morphological inversions during the ontogenesis of the ixodid ticks consist in the deranges of species-specific tendencies in the development of some external structures by the female line. The inversions, which included a wide range of organs and their fine structures, have been described for the first time in 14 species of 4 from 7 Palearctic ixodid genera. Emphasis is placed on the study of the structures, which serve as differential characters for closely related species. It is shown, that the using of the structures subjected to inversions is unavoidable in systematics because of the great similarity of closely related species, especially in immature stages. It is established by the data on the variability of all active stages in the species distribution ranges, that the degree of the inversions manifestation may somewhat fluctuate in different subspecies or geographic morphotypes of the same species, but the peculiarity of the inversions always remains a species-specific character. The cause of inversions origin is the evolution of the Ixodidae by the way of morpho-ecological specialization, namely hypertrophic, giantism, the growth of teguments in the period of nutrition act by pasture ambushing, which led to the derange of the development coordination of the organs during ontogenesis. Biological implication of the inversions is a guarantee of the adaptive potential of species during the process of microevolution. Even though the inversions make identification of closely related species difficult, their substantial importance is that they form integral species-specific character for the whole active part of the species ontogenesis.
Gene Therapy Approach for Intervertebral Disc Degeneration: An Update (2020)

Intervertebral disc degeneration is the primary cause of back pain and associated with neurological disorders including radiculopathy, myelopathy, and paralysis. The currently available surgical treatments predominantly include the excision of pathological discs, resulting in the function loss, immobilization, and potential additional complications due to the altered biomechanics. Gene therapy approach involves gene transfer into cells, affects RNA and protein synthesis of the encoded genes in the recipient cells, and facilitates biological treatment. Relatively long-exerting therapeutic effects by gene therapy are potentially advantageous to treat slow progressive degenerative disc disease. In gene therapy, the delivery method and selection of target gene(s) are essential. Although gene therapy was first mediated by viral vectors, technological progress has enabled to apply nonviral vectors and polyplex micelles for the disc. While RNA interference successfully provides specific downregulation of multiple genes in the disc, clustered regularly interspaced short palindromic repeats (CRISPR) system has increased attention to alter the process of intervertebral disc degeneration. Then, more recent findings of our studies have suggested autophagy, the intracellular self-digestion, and recycling system under the negative regulation by the mammalian target of rapamycin (mTOR), as a gene therapy target in the disc. Here we briefly review backgrounds and applications of gene therapy for the disc, introducing strategies of autophagy and mTOR signaling modulation through selective RNA interference.
hAda3 Degradation by Papillomavirus Type 16 E6 Correlates with Abrogation of the p14ARF-p53 Pathway and Efficient Immortalization of Human Mammary Epithelial Cells (2008)

Two activities of human papillomavirus type 16 E6 (HPV16 E6) are proposed to contribute to the efficient immortalization of human epithelial cells: the degradation of p53 protein and the induction of telomerase. However, the requirement for p53 inactivation has been debated. Another E6 target is the hAda3 protein, a p53 coactivator and a component of histone acetyltransferase complexes. We have previously described the role of hAda3 and p53 acetylation in p14ARF-induced human mammary epithelial cell (MEC) senescence (P. Sekaric, V. A. Shamanin, J. Luo, and E. J. Androphy, Oncogene 26:6261-6268, 2007). In this study, we analyzed a set of HPV16 E6 mutants for the ability to induce hAda3 degradation. E6 mutants that degrade hAda3 but not p53 could abrogate p14ARF-induced growth arrest despite the presence of normal levels of p53 and efficiently immortalized MECs. However, two E6 mutants that previously were reported to immortalize MECs with low efficiency were found to be defective for both p53 and hAda3 degradation. We found that these immortal MECs select for reduced p53 protein levels through a proteasome-dependent mechanism. The findings strongly imply that the inactivation of the p14ARF-p53 pathway, either by the E6-mediated degradation of p53 or hAda3 or by cellular adaptation, is required for MEC immortalization.
Optimum electromagnetic heating of nanoparticle thermal contrast agents at rf frequencies (2009)

Enhanced heating of nanoparticles for applications such as thermoacoustic imaging and therapeutic heat delivery is considered. The optimum electrical conductivity to achieve maximum electromagnetic energy deposition in a given nanoparticle is obtained, with emphasis on rf frequencies, where plasmon resonances associated with negative permittivity are generally not possible. Spheres, coated spheres, nanowires, and carbon nanotubes are considered. In all cases, it is found that relatively small conductivity values (e.g., σ⪡1 S/m for spheres) provide the maximum absorption of rf energy, and thus maximizes heat production in the nanoparticle. Therefore, lossy dielectrics may be a better choice for maximizing nanoparticle heat production than metallic particles.
New insights on oxidative stress in cancer. (2009)

Cancer initiation and progression has been linked to oxidative stress, a condition in which the balance between production and disposal of reactive oxygen or nitrogen species is altered. Oxidative stress has several protumorigenic effects, such as increasing DNA mutation rate or inducing DNA damage, genome instability and cell proliferation. Conversely, oxidative stress also exerts antitumorigenic actions, and it is has been linked to senescence and apoptosis, two major mechanisms that counteract tumor development. In this review, recent findings that relate oxidative stress to cancer-associated conditions, such as chronic inflammation, steroid hormone signaling and altered chromosome segregation, are highlighted, and how these studies may identify new targets for the development of drugs and strategies for cancer prevention and cure is discussed.
A Health Care System Based on PLC and Zigbee (2007)

In this paper, we introduce an intelligent remote health care system based on powerline communication (PLC) networks and Zigbee. It consists of a set of physiological sensors, a Zigbee/PLC gateway connected to sensors wirelessly and special software in the controlling center. Physiological data collected by sensors will be transmitted via Zigbee/PLC networks to the controlling center where the data is stored, analyzed and present to users in a visual way. First, there is an overview about PLC and Zigbee techniques. Second, system architecture of the health care system is proposed. Then, we focus on the details about the individual subsystems. We also describe the network protocols, working process and application of the system.