gebhart/patrepeval huggingface dataset:
A Comparison of Portable Dynamic Web Content Technologies for the Apache Server (2002)

Apache is considered to be the most extensible, secure and widely used server on the Internet. On our talk we focus on its first characteristic, extensibility, analyzing many techniques used to provide dynamic content. Available solutions are based either on extensions to the web server itself or on the execution of userspace programs. These solutions include, among others, CGI scripts, PHP, mod perl, mod python and Java Servlets. For each technology we present its basic design goals and the development facilities it offers. We compare the efficiency of these technologies by means of custom-made benchmarks we run to measure each solution’s throughput. Finally, we present each technique’s drawbacks, with references to lessons learned during the complete deploy-and-test process.
First arrival time calculation in 3‐D media using finite difference method (1999)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1999First arrival time calculation in 3‐D media using finite difference methodAuthors: Chaoguang ZhouLanbo LiuChaoguang ZhouUniversity of Connecticut and Lanbo LiuUniversity of Connecticuthttps://doi.org/10.1190/1.1820778 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1820778FiguresReferencesRelatedDetailsCited byParsimonious 3D post-stack Kirchhoff depth migrationGeophysical Prospecting, Vol. 53, No. 4 SEG Technical Program Expanded Abstracts 1999ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1999 Pages: 2061 publication data© 1999 Copyright © 1999 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 04 Jan 2005 CITATION INFORMATION Chaoguang Zhou and Lanbo Liu, (1999), "First arrival time calculation in 3‐D media using finite difference method," SEG Technical Program Expanded Abstracts : 1406-1409. https://doi.org/10.1190/1.1820778 Plain-Language Summary PDF DownloadLoading ...
A new method for measuring the body density of obese adults (1979)

1. A new apparatus is described with which it is possible to measure the volume (and hence density) of obese patients without requiring them to immerse totally in water. Replicate measurements of subjects with 6, 23 and 38 kg body fat had a standard deviation not greater than 0.3 kg fat. 2. In nineteen obese women body fat was measured by density, total body water, and total body potassium at the beginning, and again at the end, of a period of 3--4 weeks on a reducing diet, during which they lost 5.43 (SD 1.83) kg in weight. The composition of weight loss was also estimated both by energy balance and nitrogen balance during the interval between the two measurements of body composition. 3. The estimates of fat content of the ninetten women at the start of the balance period were 45.63 (SD 14.50) kg by density, 48.07 (SD 13.88) kg by K and 47.09 (SD 13.85) kg by water. The correlation coefficient between the density and K estimate was 0.949, and for the density and water estimate it was 0.971. 4. It is concluded that measurement of density by the new method provides a convenient method for estimating body fatness, and change in fat content, which compares favourably with estimates based on total body water or total body K. However, these methods cannot be used to provide an accurate estimate of the composition of a small weight loss in an individual since deviations up to 4 kg fat occur between fat loss based on change in density and those based on the more reliable (but more tedious) energy balance method.
Ischemia and Reperfusion Enhance ATF-2 and c-Jun Binding to cAMP Response Elements and to an AP-1 Binding Site from the c-jun Promoter (1995)

The transcription factors controlling the complex genetic response to ischemia and their modes of regulation are poorly understood. We found that ATF-2 and c-Jun DNA binding activity is markedly enhanced in post-ischemic kidney or in LLC-PK1 renal tubular epithelial cells exposed to reversible ATP depletion. After 40 min of renal ischemia followed by reperfusion for as little as 5 min, binding of ATF-2 and c-Jun, but not ATF-3 or CREB (cAMP response element binding protein), to oligonucleotides containing either an ATF/cAMP response element (ATF/CRE) or the jun2TRE from the c-jun promoter, was significantly increased. Binding to jun2TRE and ATF/CRE oligonucleotides occurred with an identical time course. In contrast, nuclear protein binding to an oligonucleotide containing a canonical AP-1 element was not detected until 40 min of reperfusion, and although c-Jun was present in the complex, ATF-2 was not. Incubating nuclear extracts from reperfused kidney with protein phosphatase 2A markedly reduced binding to both the ATF/CRE and jun2TRE oligonucleotides, compatible with regulation by an ATF-2 kinase. An ATF-2 kinase, which phosphorylated both the transactivation and DNA binding domains of ATF-2, was activated by reversible ATP depletion. This kinase coeluted on Mono Q column chromatography with a c-Jun amino-terminal kinase and with the peak of stress-activated protein kinase, but not p38, immunoreactivity. In conclusion, DNA binding activity of ATF-2 directed at both ATF/CRE and jun2TRE motifs is modulated in response to the extreme cellular stress of ischemia and reperfusion or reversible ATP depletion. Phosphorylation-dependent activation of the DNA binding activity of ATF-2, which appears to be regulated by the stress-activated protein kinases, may play an important role in the earliest stages of the genetic response to ischemia/reperfusion by targeting ATF-2 and c-Jun to specific promoters, including the c-jun promoter and those containing ATF/CREs.
Proceedings of International Conference on Advances in Mobile Computing & Multimedia (2013)

Welcome to the 11th International Conference on Mobile Computing & Multimedia (MoMM), held in conjunction with the 15th International Conference on Information Integration and Web-based Applications & Services (iiWAS). MoMM2013 is held in Vienna, Austria, on 2-4 December 2013.
Private Providers a Cause for Concern in the Public Education Sector (2010)

The secrecy surrounding the agreement signed by the management of the University of Newcastle with the ASX-listed company Navitas has become a cause of concern for staff and employees at the University. The need for the government to investigate how public universities in New South Wales (NSW) are dealing with the private sector is highlighted.
Development of Growth Technologies for the Photonic Single Crystals by the Czochralski Method at Institute for Single Crystals, NAS of Ukraine (2013)

The present paper briey overviews the application of the Czochralski method for growth of a set of oxide crystals for photonics, as well as the design of equipment at the Institute for Single Crystals, NAS of Ukraine.
FRACTURE TOUGHNESS OF VARIOUS CORE MATERIALS (2001)

This investigation evaluated the fracture toughness() of eight currently available core materials, and relate the fracture toughness value to fractography analysis and surface characteristics using a atomic force microscope (AFM). Single-edge notched (SEN) test specimens (n=10) and compact tension (CT) test specimens (n=10) were prepared conforming to the ASTM Standard E-399 for a high copper amalgam, three composite core materials (Core-Max II, Core Paste, Bisfil Core), two reinforced composite core materials (Ti-Core, Ti-Core Natural), a resin-modified glass ionomer core material (Vitremer), and a conventional glass ionomer core material (Ketac-Molar). The specimens were tested with an Instron Universal Testing Machine. The maximum loads were measured to calculate the fracture toughness (). Thereafter, fracture surfaces of SEN specimens of each material were investigated for fractography analysis using scanning electron microscope. And, disc-shaped specimens with 1mm thickness were fabricated for each material and were investigated under AFM for surface morphology analysis. The results were as follows: 1. Bisfil Core showed the highest mean fracture toughness regardless of test methods. 2. For the tooth-colored materials, Ti-Core Natural exhibited the highest fracture toughness. 3. Ketac Molar showed a significantly low fracture toughness when compared with the amalgam and the composite resin core materials(p&amp;lt;0.05). 4. The fracture toughness values obtained with the single-edge notched test, except Ketac Molar, were higher than those obtained in the compact tension test. 5. SEM revealed that the fracture surface of high fracture toughness material was rougher than that of low fracture toughness material. 6. AFM revealed that the surface particles of the composite resins were smaller in size, with a lower surface roughness than the glass ionomer core materials.
Computer‐aided diagnosis: Automatic detection of malignant masses in digitized mammograms (1998)

A computerized method to automatically detect malignant masses on digital mammograms based on bilateral subtraction to identify asymmetries between left and right breast images was developed. After the digitization, in order to align left and right mammograms the breast border and nipple were automatically detected. Images were corrected to avoid differences in brightness due to the recording procedure. Left and right mammograms were subtracted and a threshold was applied to obtain a binary image with the information of suspicious areas. The suspicious regions or asymmetries were delimited by a region growing algorithm. Size and eccentricity tests were used to eliminate false-positive responses and texture features were extracted from suspicious regions to reject normal tissue regions. The scheme, tested in 70 pairs of digital mammograms, achieved a true-positive rate of 71% with an average number of 0.67 false positives per image. Computerized detection was evaluated by using free-response operating characteristic analysis (FROC). An area under the AFROC (A1) of 0.667 was obtained. Our results show that the scheme may be helpful to the radiologists by serving as a second reader in mammographic screening. The low number of false positives indicates that our scheme would not confuse the radiologist by suggesting normal regions as suspicious.
Laser-induced breakdown spectroscopy for the environmental determination of total carbon and nitrogen in soils (2003)

Soils from various sites have been analysed with the laser-induced breakdown spectroscopy (LIBS) technique for total elemental determination of carbon and nitrogen. Results from LIBS have been correlated to a standard laboratory-based technique (sample combustion), and strong linear correlations were obtained for determination of carbon concentrations. The LIBES technique was used on soils before and after acid washing, and the technique appears to be useful for the determination of both organic and inorganic soil carbon. The LIBS technique has the potential to be packaged into a field-deployable instrument.
Trafficking of High Avidity HER-2/neu-Specific T Cells into HER-2/neu-Expressing Tumors after Depletion of Effector/Memory-Like Regulatory T Cells (2012)

Depletion of CD25(low) Tregs allows activation of tumor-clearing high avidity T cells. Thus, the development of agents that specifically deplete Treg subsets should translate into more effective immunotherapies while avoiding autoimmunity.
Phase I-II evaluation of cyclocytidine. (1977)

A phase I-II study of cyclocytidine was conducted in 102 patients, 96 of whom had metastatic solid tumors and six of whom had acute leukemia. The drug was administered in 5- or 10-day courses of single daily iv or sc injections of 100-675 mg/m2 day. Two complete and six partial responses were observed in 64 solid tumor patients evaluable for response, 52 of whom had malignant melanoma or adenocarcinoma of gastrointestinal origin. The median duration of the responses was 6 months. An additional seven patients achieved stabilization of their disease for greater than or equal to 2 months. No responses occurred in six patients with acute leukemia. Side effects included nausea and vomiting, postural hypotension, and parotid pain, occurring in approximatley one third of patients receiving greater than 200 mg/m2/day. No myelosuppression was observed in six patients receiving 5-day courses of 100-200 mg/m2/day. Myelosuppressive toxicity became increasingly severe with doses greater than 200 mg/m2/day x 10, related at least in part to prior chemotherapy exposure including the nitrosoureas.
Prestimulus alpha and mu activity predicts failure to inhibit motor responses (2009)

Do certain brain states predispose humans to commit errors in monotonous tasks? We used MEG to investigate how oscillatory brain activity indexes the brain state in subjects performing a Go-noGo task. Elevated occipital alpha and sensorimotor mu activity just prior to the presentation of the stimuli predicted an upcoming error. An error resulted in increased frontal theta activity and decreased posterior alpha activity. This theta increase and alpha decrease correlated on a trial-by-trial basis reflecting post-error functional connectivity between the frontal and occipital regions. By examining the state of the brain before a stimulus, we were able to show that it is possible to predict lapses of attention before they actually occur. This supports the case that the state of the brain is important for how incoming stimuli are processed and for how subjects respond.
Steel defect classification with Max-Pooling Convolutional Neural Networks (2012)

We present a Max-Pooling Convolutional Neural Network approach for supervised steel defect classification. On a classification task with 7 defects, collected from a real production line, an error rate of 7% is obtained. Compared to SVM classifiers trained on commonly used feature descriptors our best net performs at least two times better. Not only we do obtain much better results, but the proposed method also works directly on raw pixel intensities of detected and segmented steel defects, avoiding further time consuming and hard to optimize ad-hoc preprocessing.
A novel group of <i>pumilio</i> mutations affects the asymmetric division of germline stem cells in the <i>Drosophila</i> ovary (1997)

Germline stem cells play a pivotal role in gametogenesis; yet little is known about how they are formed, how they divide to self-renew, and how these processes are genetically controlled. Here we describe the self-renewing asymmetric division of germline stem cells in the Drosophila ovarian germline, as marked by the spectrosome, a cytoplasmic structure rich in membrane skeletal proteins. The ontogeny of the spectrosome marks the lineage of germline stem cells. We identified two new groups of mutations in which the divisional asymmetry is disrupted. The first, which we refer to as ovarette (ovt) mutations, was shown to correspond to a novel class of mutations in the pumilio locus. Since pumilio is known to posttranscriptionally repress the expression of target genes at earlier stages of germ cell development, our results suggest that a similar activity is needed to maintain germ line stem cells. We have also identified a second and novel gene, piwi, whose mutations abolish germline stem cell division.
Influence of Age on the Hemodynamic Response to Exercise (1967)

Respiratory and hemodynamic measurements were made on 54 sedentary subjects during progressive exercise on a bicycle ergometer up to the point of maximal voluntary effort. The age range of the group was from 18 to 68 years. The maximum tolerated exercise, as indicated by the highest achieved level of oxygen consumption (V o o2 ), diminished with age. Older subjects had a lower resting cardiac output (Q) than normal subjects, but an identical increase in Q with V o o2 . There was no evidence of flattening of this curve as the older subjects approached highest exercise loads. Consequently, the arteriovenous oxygen difference did not increase abnormally on high loads, and the cardiac response to exercise in older subjects appeared to be adequate. The relationship between inspired air volume and heart rate with V o o2 at submaximal loads was not influenced by age. Systolic pressure increased progressively with exercise and showed a greater change in older subjects. Total peripheral resistance at rest increased with age; but with increasing exercise, this difference progressively diminished.
Development of immunogenic recombinant Oka varicella vaccine expressing hepatitis B virus surface antigen (1991)

Recombinant Oka varicella vaccine expressing hepatitis B virus (HBV) surface antigen (HBs) was constructed by inserting the HBs gene into the viral thymidine kinase (TK) gene and was examined for its immunogenicity in guinea-pigs. The HBs gene encoding 25 amino acids of preS2 and the whole of the S region was inserted into the TK gene of the cloned plasmid. The chimeric plasmid DNA and Oka varicella vaccine DNA were cotransfected and recombinant virus was isolated after immunofluorescence screening using a monoclonal antibody to HBs and a fluorescein-conjugated anti-mouse antibody. Expression of viral HBs was detected in the cytoplasm of infected cells and was stable over several repeated passages in vitro. The recombinant virus expressed 26K and 30K HBs molecules in infected cells and the culture supernatant contained 30K and 35K HBs molecules. HBs was purified at a density of 1.20 g/ml from the culture supernatants. The recombinant virus induced an antibody response to HBs as well as to varicella-zoster virus (VZV) in guinea-pigs, and the antibody titre to HBs was comparable to that induced by a recombinant HBs subunit vaccine produced in yeast. Thus a single dose of live recombinant Oka varicella vaccine could induce good immunity to VZV and HBs. The recombinant Oka varicella vaccine expressing HBs may be a good candidate for a combined HBV and VZV vaccine.
81 fJ/bit energy-to-data ratio of 850 nm vertical-cavity surface-emitting lasers for optical interconnects (2011)

Extremely energy-efficient oxide-confined high-speed 850 nm vertical-cavity surface-emitting lasers for optical interconnects are presented. Error-free performance at 17 and 25 Gb/s via a 100 m multimode fiber link is demonstrated at record high dissipation-power-efficiencies of up to 69 fJ/bit (&lt;0.1 mW/Gbps) and 99 fJ/bit, respectively. These are the most power efficient high-speed directly modulated light sources reported to date. The total energy-to-data ratio is 83 fJ/bit at 25 °C and reduces to 81 fJ/bit at 55 °C. These results were obtained without adjustment of driving conditions. A high D-factor of 12.0 GHz/(mA)0.5 and a K-factor of 0.41 ns are measured.
GATA4, 5 and 6 mediate TGFβ maintenance of endodermal gene expression in<i>Xenopus</i>embryos (2005)

The individual contributions of the three vertebrate GATA factors to endoderm formation have been unclear. Here we detail the early expression of GATA4, 5 and 6 in presumptive endoderm in Xenopus embryos and their induction of endodermal markers in presumptive ectoderm. Induction of HNF3beta by all three GATA factors was abolished when protein synthesis was inhibited, showing that these inductions are indirect. In contrast, whereas induction of Sox17alpha and HNF1beta by GATA4 and 5 was substantially reduced when protein synthesis was inhibited, induction by GATA6 was minimally affected, suggesting that GATA6 is a direct activator of these early endodermal genes. GATA4 induced GATA6 expression in the same assay and antisense morpholino oligonucleotides (MOs), designed to knock down translation of GATA6, blocked induction of Sox17alpha and HNF1beta by GATA4, suggesting that GATA4 induces these genes via GATA6 in this assay. All three GATA factors were induced by activin, although GATA4 and 6 required lower concentrations. GATA MOs inhibited Sox17alpha and HNF1beta induction by activin at low and high concentrations in the order: GATA6>GATA4>GATA5. Together with the timing of their expression and the effects of GATA MOs in vivo, these observations identify GATA6 as the predominant GATA factor in the maintenance of endodermal gene expression by TGFbeta signaling in gastrulating embryos. In addition, examination of gene expression and morphology in later embryos, revealed GATA5 and 6 as the most critical for the development of the gut and the liver.
Intracellular Signal-Responsive Artificial Gene Regulation for Novel Gene Delivery (2002)

We describe two types of artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) or caspase-3. These molecular systems use newly synthesized cationic polymers, PAK and PAC. The PAK polymer includes substrate oligopeptide for PKA, ARRASLG, as receptor of PKA signal, while the PAC polymer possesses oligopeptide that is comprised of a substrate sequence of caspase-3, DEVD, and a cationic oligolysine, KKKKKK. These polymers formed stable complexes with DNA to totally suppress the gene expression. However, PKA or caspase-3 signal disintegrates the PAK-DNA or the PAC-DNA complex, respectively. This liberates the DNA and activated the gene expression. These systems are the first concept of an intracellular signal-responsive gene-regulation system using artificial polymer. We expect that these systems can be applied to the novel highly cell specific gene delivery strategy that is involved in our previously proposed new drug delivery concept, the drug delivery system based on responses to cellular signals.
Screening of Complement Inhibitors: Shielded Baculoviruses Increase the Safety and Efficacy of Gene Delivery (2010)

One of the major obstacles in the use of baculovirus vectors for in vivo gene transfer is the virus inactivation by serum complement. In this study, we investigated the effect of decay-accelerating factor (DAF), factor H (FH)-like protein-1 (FHL-1), C4b-binding protein (C4BP), and membrane cofactor protein (MCP) on protection of baculovirus vectors from the complement-mediated inactivation. Complement regulatory proteins were displayed on baculovirus surface as fusions to membrane anchor of the vesicular stomatitis virus-G (VSV-G) protein. This strategy resulted in abundant expression of recombinant proteins on the viral envelope while viral titers comparable to control virus were reached. The surface-modified vectors exhibited complement resistance in vitro, DAF showing the highest level of protection. Intraportal delivery of DAF-displaying baculovirus resulted in increased survival and enhanced gene expression in immunocompetent mice. Mice receiving DAF-displaying baculovirus also exhibited lower level of liver inflammation as evidenced by aspartate aminotransferase (AST). In line with this, macrophages treated with DAF baculovirus produced lower levels of inflammatory cytokines IL-1beta, IL-6, and IL-12p40 compared to control virus. These results suggest that DAF-display can protect the vector against complement inactivation but also reduce complement-mediated inflammation injury. In conclusion, complement shielded baculovirus vectors represent attractive tools for effective in vivo gene delivery.
Phase IB Study of Vemurafenib in Combination with Irinotecan and Cetuximab in Patients with Metastatic Colorectal Cancer with <i>BRAF</i> V600E Mutation (2016)

Vemurafenib, in combination with irinotecan and cetuximab, was well tolerated in patients with refractory, BRAF-mutated metastatic colorectal cancer, and both survival outcomes and response rates exceeded prior reports for vemurafenib and for irinotecan plus cetuximab in BRAF<sup>V600E</sup> metastatic colorectal cancer. In vivo models demonstrated regressions with the triplet, in contrast with vemurafenib and cetuximab alone. cfDNA predicted radiographic response and identified mutations reactivating the MAPK pathway upon progression. Cancer Discov; 6(12); 1352-65. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 1293.