gebhart/patrepeval huggingface dataset:
Two inhibitors of neutrophil chemotaxis are produced by hyperimmunoglobulin E recurrent infection syndrome mononuclear cells exposed to heat-killed staphylococci (1983)

Mononuclear cells from normal volunteers and from patients with the hyperimmunoglobulin E recurrent infection syndrome (HIE) were cultured for 18 h with and without opsonized, heat-killed Staphylococcus aureus (OS). The supernatants from normal mononuclear cell cultures without OS revealed no inhibitory activity for neutrophil chemotaxis, whereas those from HIE patients revealed the previously reported 61,000-dalton factor. However, when normal cells were cultured with OS, they produced a proteinaceous, 56 degrees C-stable, 30,000- to 45,000-dalton factor which preferentially inhibited neutrophil versus monocyte chemotaxis. When HIE cells were exposed to OS, they produced the same 30,000- to 45,000-dalton factor as normal cells, as well as the 61,000-dalton factor that they produced spontaneously. Assay of 1,000-fold dilutions of supernatants from cultures of normal mononuclear cells with OS revealed a mean production of 7.8 +/- 5.4% inhibition of chemotaxis, whereas assay of 1,000-fold dilutions of supernatants from cultures of HIE mononuclear cells (spontaneously producing the 61,000-dalton factor) with OS revealed a 26.6 +/- 3.6% inhibition (P less than 0.02). The data indicate that in short-term culture both normal and HIE mononuclear cells produce an inhibitor of neutrophil chemotaxis when exposed to particulate heat-killed staphylococci but that HIE cells produce qualitatively and quantitatively more inhibitory activity.
A highly resilient routing algorithm for fault-tolerant NoCs (2009)

Current trends in technology scaling foreshadow worsening transistor reliability as well as greater numbers of transistors in each system. The combination of these factors will soon make long-term product reliability extremely difficult in complex modern systems such as systems on a chip (SoC) and chip multiprocessor (CMP) designs, where even a single device failure can cause fatal system errors. Resiliency to device failure will be a necessary condition at future technology nodes. In this work, we present a network-on-chip (NoC) routing algorithm to boost the robustness in interconnect networks, by reconfiguring them to avoid faulty components while maintaining connectivity and correct operation. This distributed algorithm can be implemented in hardware with less than 300 gates per network router. Experimental results over a broad range of 2D-mesh and 2D-torus networks demonstrate 99.99% reliability on average when 10% of the interconnect links have failed.
Toward Robust Distance Metric Analysis for Similarity Estimation (2006)

In this paper, we present a general guideline to establish the relation between a distribution model and its corresponding similarity estimation. A rich set of distance metrics, such as harmonic distance and geometric distance, is derived according to Maximum Likelihood theory. These metrics can provide a more accurate feature model than the conventional Euclidean distance (SSD) and Manhattan distance (SAD). Because the feature elements are from heterogeneous sources and may have different influence on similarity estimation, the assumption of single isotropic distribution model is often inappropriate. We propose a novel boosted distance metric that not only finds the best distance metric that fits the distribution of the underlying elements but also selects the most important feature elements with respect to similarity. We experiment with different distance metrics for similarity estimation and compute the accuracy of different methods in two applications: stereo matching and motion tracking in video sequences. The boosted distance metric is tested on fifteen benchmark data sets from the UCI repository and two image retrieval applications. In all the experiments, robust results are obtained based on the proposed methods.
Experimental Study of Advanced Helmholtz Resonator Liners with Increased Acoustic Performance by Utilising Material Damping Effects (2018)

In aero engines, noise absorption is realised by acoustic liners, e.g., Helmholtz resonator (HR) liners, which often absorb sound only in a narrow frequency range. Due to developments of new engine generations, an improvement of overall acoustic damping performance and in particular more broadband noise absorption is required. In this paper, a new approach to increase the bandwidth of noise absorption for HR liners is presented. By replacing rigid cell walls in the liner’s honeycomb core structure by flexible polymer films, additional acoustic energy is dissipated. A manufacturing technology for square honeycomb cores with partially flexible walls is described. Samples with different flexible wall materials were fabricated and tested. The acoustic measurements show more broadband sound absorption compared to a reference liner with rigid walls due to acoustic-structural interaction. Manufacturing-related parameters are found to have a strong influence on the resulting vibration behaviour of the polymer films, and therefore on the acoustic performance. For future use, detailed investigations to ensure the liner segments compliance with technical, environmental, and life-cycle requirements are needed. However, the results of this study show the potential of this novel liner concept for noise reduction in future aero-engines.
Ligand-induced Epitope Masking (2016)

We previously demonstrated that Arg-Gly-Asp (RGD)-containing ligand-mimetic inhibitors of integrins are unable to dissociate pre-formed integrin-fibronectin complexes (IFCs). These observations suggested that amino acid residues involved in integrin-fibronectin binding become obscured in the ligand-occupied state. Because the epitopes of some function-blocking anti-integrin monoclonal antibodies (mAbs) lie near the ligand-binding pocket, it follows that the epitopes of these mAbs may become shielded in the ligand-occupied state. Here, we tested whether function-blocking mAbs directed against α5β1 can interact with the integrin after it forms a complex with an RGD-containing fragment of fibronectin. We showed that the anti-α5 subunit mAbs JBS5, SNAKA52, 16, and P1D6 failed to disrupt IFCs and hence appeared unable to bind to the ligand-occupied state. In contrast, the allosteric anti-β1 subunit mAbs 13, 4B4, and AIIB2 could dissociate IFCs and therefore were able to interact with the ligand-bound state. However, another class of function-blocking anti-β1 mAbs, exemplified by Lia1/2, could not disrupt IFCs. This second class of mAbs was also distinguished from 13, 4B4, and AIIB2 by their ability to induce homotypic cell aggregation. Although the epitope of Lia1/2 was closely overlapping with those of 13, 4B4, and AIIB2, it appeared to lie closer to the ligand-binding pocket. A new model of the α5β1-fibronectin complex supports our hypothesis that the epitopes of mAbs that fail to bind to the ligand-occupied state lie within, or very close to, the integrin-fibronectin interface. Importantly, our findings imply that the efficacy of some therapeutic anti-integrin mAbs could be limited by epitope masking.
Cleavage of 2-nitrocyclohexanone by base (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCleavage of 2-nitrocyclohexanone by baseAlbert S. Matlack and David S. BreslowCite this: J. Org. Chem. 1967, 32, 6, 1995–1996Publication Date (Print):June 1, 1967Publication History Published online1 May 2002Published inissue 1 June 1967https://pubs.acs.org/doi/10.1021/jo01281a067https://doi.org/10.1021/jo01281a067research-articleACS PublicationsRequest reuse permissionsArticle Views118Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structure of the hexagonal phase of the sodium dodecyl sulfate and water system (1996)

The hexagonal cell parameter a of the system sodium dodecyl sulfate and water in the ${\mathit{H}}_{\mathrm{\ensuremath{\alpha}}}$ phase as a function of volume concentration ${\mathit{c}}_{\ensuremath{\nu}}$ presents the functional behavior expected for rigid and finite objects: a\ensuremath{\propto}${\mathit{c}}_{\ensuremath{\nu}}^{\mathrm{\ensuremath{-}}1/3}$. The micellar particle length is, however, unknown since its derivation depends intrinsically on the particle radius R considered. A constant radius is found for the whole ${\mathit{H}}_{\mathrm{\ensuremath{\alpha}}}$ domain, and the electron density maps obtained from the x-ray diffracted intensities are analyzed and allow determination of micellar radius (effective radius ${\mathit{R}}_{\mathrm{eff}}$=18.4\ifmmode\pm\else\textpm\fi{}0.1 \AA{}, paraffin radius ${\mathit{R}}_{\mathrm{par}}$=16.7\ifmmode\pm\else\textpm\fi{}0.1 \AA{}, and total radius ${\mathit{R}}_{\mathrm{tot}}$=20.5\ifmmode\pm\else\textpm\fi{}1.0 \AA{}). From these values the resulting micellar size is between 170 and 640 \AA{}, with a value of 260 \AA{} for ${\mathit{R}}_{\mathrm{tot}}$=20.5 \AA{}. \textcopyright{} 1996 The American Physical Society.
Removing Heavy Metals from Phosphoric Acid and Phosphate Fluid Fertilizers (1992)

Heavy metals in wet-process phosphoric acid (WPA) and phosphate fluid fertilizers are an environmental concern in the United States and Europe. To address this concern, several organic and inorganic reagents were evaluated as precipitants for heavy metals in a 10-34-0 (N-P2O5-K2O) fluid fertilizer and WPA. Trisodium trithiocyanuric acid (TMT-15), sodium polythiocarbonate (Thio-Red II), and sodium trithiocarbonate (5% Na2CS3) precipitated arsenic, cadmium, copper, mercury, lead, and zinc from 10-34-0. Ammonium cyanurate was ineffective in removing cadmium from 10-34-0. Thio-Red II and 5% Na2CS3 precipitated mercury, lead, cadmium, copper, and chromium from WPA. A water-insoluble starch xanthate adsorbed mercury, copper, and lead from 10-34-0 and WPA. Sodium sulfide, sodium polysulfide, and potassium ferrocyanide were tested as inorganic precipitants. The polysulfide was twice as effective as the sulfide alone, and concentrations of less than 10 ppm of arsenic, cadmium, mercury, and lead were achieved in 10-34-0. Ferrocyanide reduced the concentrations of cadmium and nickel to less than 10 ppm in WPA.
CuInSe/sub 2/ films prepared by screen-printing and sintering method (1988)

The production of polycrystalline CuInSe/sub 2/ films by the screen-printing and sintering method is presented. To prepare fine powder for the screen-printing CuInSe/sub 2/ paste, pure Cu, In, and Se powders were mixed and ground in an agate ball mill with distilled water or ethylene glycol monophenyl ether to a grain size of around 1.5 mu m. It was found that CuInSe/sub 2/ is formed during the grinding process at room temperature, and its quantity increases proportionally to grinding time. The CuInSe/sub 2/ film is p-type with a resistivity of 1.1 Omega cm, Hall mobility of 1.0 cm/sup 2//Vs, and carrier concentration of 6.4*10/sup 18/ cm/sup -3/, and the optical bandgap is 1.0 eV. Photovoltaic effect was observed in a CdS/CuInSe/sub 2/ heterojunction fabricated by depositing CdS film on the sintered CuInSe/sub 2/ by RF sputtering.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Transition-Metal (Ti,V,Cr,Mn,Fe,Co,Cu) Containing Ordered Nanoporous Materials:Novel Heterogeneous Catalysts for Selective Oxidation Reactions (2006)

Transition-metal (Ti,V,Cr,Mn,Fe,Co,Cu) containing periodic nanoporous catalysts, were synthesized hydrothermally and characterized using various analytical and spectroscopic techniques. The catalytic performance of the different catalysts was systematically evaluated with a detailed study on TiMCM-41. All the catalysts showed promise for the selective oxidation of cycloalkanes, viz., cyclohexane, cyclooctane, and cyclododecane, under mild reaction conditions. Furthermore, these mesoporous molecular sieves were also active for all the chosen reactions even after several recycling and/or washing treatments. Among the various materials under investigation, the catalysts TiMCM-41 and VMCM-41 showed much higher substrate conversion and excellent product selectivity in conjunction with a minimal leaching of the active species. More importantly, the influence of pore size on the catalytic activity of the bulkier substrates such as cyclooctane and cyclododecane is demonstrated.
Dye-mediated photolysis of human neuroblastoma cells: implications for autologous bone marrow transplantation (1986)

Cells from three different human neuroblastoma cell lines and normal human bone marrow cells were exposed to the lipophilic fluorescent dye, merocyanine 540 (MC 540), and white light. In vitro clonogenic tumor cells were inactivated up to 25,000 times more rapidly than multipotent hematopoietic progenitor cells (CFU-GEMM). It is conceivable that this pronounced difference in sensitivity to MC 540-mediated photolysis can be exploited for the selective killing of residual neuroblastoma cells in autologous remission marrow grafts.
Bisphosphonates (2006)

The discovery and development of the bisphosphonates (BPs) as a major class of drugs for the treatment of bone diseases has been a fascinating journey that is still not over. In clinical medicine, several BPs are established as the treatments of choice for various diseases of excessive bone resorption, including Paget's disease of bone, myeloma and bone metastases, and osteoporosis. Bisphosphonates are chemically stable analogues of inorganic pyrophosphate, and are resistant to breakdown by enzymatic hydrolysis. Bisphosphonates inhibit bone resorption by being selectively taken up and adsorbed to mineral surfaces in bone, where they interfere with the action of the bone-resorbing osteoclasts. Bisphosphonates are internalized by osteoclasts and interfere with specific biochemical processes. Bisphosphonates can be classified into at least two groups with different molecular modes of action. The simpler non-nitrogen-containing bisphosphonates (such as clodronate and etidronate) can be metabolically incorporated into nonhydrolyzable analogues of adenosine triphosphate (ATP) that may inhibit ATP-dependent intracellular enzymes. The more potent, nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate, and zoledronate) are not metabolized in this way but can inhibit enzymes of the mevalonate pathway, thereby preventing the biosynthesis of isoprenoid compounds that are essential for the posttranslational modification of small GTP-binding proteins (which are also GTPases) such as rab, rho, and rac. The inhibition of protein prenylation and the disruption of the function of these key regulatory proteins explain the loss of osteoclast activity and induction of apoptosis. The key target for bisphosphonates is farnesyl pyrophosphate synthase (FPPS) within osteoclasts, and the recently elucidated crystal structure of this enzyme reveals how BPs bind to and inhibit at the active site via their critical N atoms. In conclusion, bisphosphonates are now established as an important class of drugs for the treatment of many bone diseases, and their mode of action is being unraveled. As a result their full therapeutic potential is gradually being realized.
3-D surface reconstruction from stereoscopic image sequences (2002)

A stereoscopic scene analysis system for 3-D modeling of objects from stereoscopic image sequences is described. A dense map of 3-D surface points is obtained by image correspondence, object segmentation, interpolation, and triangulation. Emphasis is put on the accurate measurement of image correspondences from grey level images. The surface geometry of each scene object is approximated by a triangular wire-frame which stores the surface texture in texture maps. Sequence processing serves to track camera motion and to fuse surfaces from different view points into a consistent 3-D surface model. From the textured 3-D models, highly realistic image sequences from arbitrary view points can be synthesized using computer graphics techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The active traffic control mechanism for layered multimedia multicast in active network (2002)

In multicasting multimedia data, effectively adapting to heterogeneous receivers is very difficult. In this paper, we propose a new scheme called the "active traffic control mechanism for layered multimedia multicasting" (ATLM) in an active network environment. The proposed scheme controls traffic at each router using the traffic condition of immediate children nodes. Also, the traffic adjustment is much finer than existing multicast protocols of single-layer granularity. Computer simulation reveals that the proposed scheme significantly improves the amount of delivered traffic and the end-to-end delay by as much as 10%, as compared to layer-wise adjustment. Moreover, it does not require one to maintain multiple sessions for transferring multi-layer data but only one session, and thus reduces the overheads on session management and network bandwidth.
Cytokines, STATs and liver disease. (2005)

The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathway, activated by more than 50 cytokines or growth factors, plays critical roles in a wide variety of cellular functions in the hematopoietic, immune, neuronal and hepatic systems. In the liver, this signaling pathway, activated by more than 20 cytokines, growth factors, hormones, and hepatitis viral proteins, plays critical roles in antiviral defense, acute phase response, hepatic injury, repair, inflammation, transformation, and hepatitis. This article reviews the biological significance of STAT1, 2, 3, 4, 5, 6 in hepatic functions and diseases.
Muralytic activity of <i>Micrococcus luteus</i> Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation (2005)

The culturability of several actinobacteria is controlled by resuscitation-promoting factors (Rpfs). These are proteins containing a c. 70-residue domain that adopts a lysozyme-like fold. The invariant catalytic glutamate residue found in lysozyme and various bacterial lytic transglycosylases is also conserved in the Rpf proteins. Rpf from Micrococcus luteus, the founder member of this protein family, is indeed a muralytic enzyme, as revealed by its activity in zymograms containing M. luteus cell walls and its ability to (i) cause lysis of Escherichia coli when expressed and secreted into the periplasm; (ii) release fluorescent material from fluorescamine-labelled cell walls of M. luteus; and (iii) hydrolyse the artificial lysozyme substrate, 4-methylumbelliferyl-beta-D-N,N',N''-triacetylchitotrioside. Rpf activity was reduced but not completely abolished when the invariant glutamate residue was altered. Moreover, none of the other acidic residues in the Rpf domain was absolutely required for muralytic activity. Replacement of one or both of the cysteine residues that probably form a disulphide bridge within Rpf impaired but did not completely abolish muralytic activity. The muralytic activities of the Rpf mutants were correlated with their abilities to stimulate bacterial culturability and resuscitation, consistent with the view that the biological activity of Rpf results directly or indirectly from its ability to cleave bonds in bacterial peptidoglycan.
Charixa Lang and Spinicharixa gen. nov., cheilostome bryozoans from the Lower Cretaceous (1986)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Physical-layer security for indoor visible light communications (2014)

This paper considers secure transmission over the visible light communication (VLC) channel by the means of physical-layer security techniques. In particular, we consider achievable secrecy rates of the multiple-input, single-output (MISO) wiretap VLC channel. The VLC channel is modeled as a deterministic and real-valued Gaussian channel subject to amplitude constraints. We utilize null-steering and artificial noise strategies to achieve positive secrecy rates when the eavesdropper's channel state information (CSI) is perfectly known and entirely unknown to the transmitter, respectively. In both scenarios, the legitimate receiver's CSI is available to the transmitter. We numerically evaluate achievable secrecy rates under typical VLC scenarios and show that simple precoding techniques can significantly improve the confidentiality of VLC links.
Human lead exposure (1992)

HISTORICAL AND ENVIRONMENTAL BACKGROUND. Saturnine Drugs and Medicinal Exposure to Lead: An Historical Outline (Jerome O. Nriagu). Modern History of Lead Poisoning - A Century of Discovery and Rediscovery (Jane S. Lin-Fu). The Monitoring of Human Lead Exposure (Paul Mushak). Lead in the Environment: From Sources to Human Receptors (Cliff I. Davidson and Michael Rabinowitz). NEUROBIOLOGICAL FACTORS. Neurological Perspective on Lead Toxicity (Eellen K. Silbergeld). Visual and Auditory System Alterations Following Developmental or Adult Lead Exposure: A Critical Review (Donald A. Fox). Developmental Neurobiology of Lead Toxicity (Gary W. Goldstein). Behavioral Impairment Produced by Developmental Lead Exposure: Evidence from Primate Research (Deborah C. Rice). HUMAN LEAD EXPOSURE. Occupational Lead Exposure (Thomas D. Matte, Philip J. Landrigan, and Edward L. Baker). Lead, the Kidney, and Hypertension (Richard P. Wedeen). Neurodevelopmental Effects of Low-Level Lead Exposure in Chi ldren (David Bellinger and Herbert L. Needleman). Low Level Lead Exposure: Effect on Quantitative Electroencephalography and Correlation with Neuropsychologic Measures (James L. Burchfiel, Frank H. Duffy, Peter H. Bartels, and Herbert L. Needleman). Lead, Blood Pressure, and Cardiovascular Disease (Joel Schwartz). Low-Level Health Effects of Lead: Growth, Developmental, and Neurological Disturbances (Joel Schwartz). Recent Epidemiologic Studies of Low Level Lead Exposure and the IQ of Children: A Meta-Analytic Review (Constantine A. Gatsonis and Herbert L. Needleman). SOCIOLOGICAL AND LEGAL ISSUES. Economic Aspects of the Litigation for Harm Due to Lead Poisoning (Richard G. Frank). The Role of Values in Science and Policy: The Case of Lead (Samuel P. Hays.
瀬戸内のアート運動と国吉康雄の結節点 : 国吉康雄記念・美術教育研究と地域創生講座主催『第３回企画展』実施のための考察 (2019)

岡山大学大学院教育学研究科国吉康雄記念・美術教育研究と地域創生講座では、1889 年、岡山市に誕生し、米国で活躍した洋画家で社会活動家でもある国吉康雄の調査・研究活動を行なってきた。この成果として、国吉康雄と、国吉康雄作品をコレクション活動の原点とし、アート作品の設置理由に、近代以降の瀬戸内海の歴史の顕彰を含む、『ベネッセアートサイト直島』の運動、及びこれに関連する瀬戸内のアートプロジェクトとを繋ぐ企画展覧会を、2019 年4 月、岡山市が運営する岡山シティーミュージアムにおいて実施する。本論は、この企画展、『X-O. Modern（クロスオーバーモダン）SETOUCHI ⇄ Y.Kuniyoshi ⇄ NEW YORK』（仮）の展示計画作成のための考察である。
Registration‐based segmentation with articulated model from multipostural magnetic resonance images for hand bone motion animation (2010)

The proposed registration-based segmentation method can successfully overcome drawbacks caused by inherent artifacts in MR images and obtain more accurate segmentation results automatically. Moreover, realistic hand motion animations can be generated based on the bone segmentation results. The proposed method is found helpful for understanding hand bone geometries in dynamic postures that can be used in simulating 3D hand motion through multipostural MR images.