gebhart/patrepeval huggingface dataset:
Molecular Machines (1998)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular MachinesVincenzo Balzani, Marcos Gómez-López, and J. Fraser StoddartView Author Information Dipartimento di Chimica “G. Ciamician”, Università di Bologna, via Selmi 2, I-40126 Bologna, Italy, and Department of Chemistry and Biochemistry, University of California at Los Angeles, 405 Hilgard Avenue, California 90095 Cite this: Acc. Chem. Res. 1998, 31, 7, 405–414Publication Date (Web):May 28, 1998Publication History Received2 December 1997Published online28 May 1998Published inissue 1 July 1998https://doi.org/10.1021/ar970340yCopyright © 1998 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views4658Altmetric-Citations623LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (221 KB) Get e-AlertsSUBJECTS:Cavities,Ions,Ligands,Noncovalent interactions,Rotaxanes Get e-Alerts
Realization of an ATM-based HFC demonstrator with high upstream capacity (2002)

Within the framework of the ACTS project ATHOC (ATM applications on Hybrid Optical fiber Coax), cable TV modems and hybrid fibre coax (HFC) systems have been realized, demonstrating the basic technologies which are common to the different HFC standardisation work-groups. The ATHOC prototypes employ 64-QAM modulation for the downstream and burst mode QPSK modulation for the upstream transmission, respectively, in order to achieve 40 Mb/s and 3 Mb/s. Time division multiple access (TDMA) is the method which is implemented to give all users access to the shared medium of the tree-and-branch CATV network. The article clarifies the HFC system concept which was implemented. The functions of the access network adaptation in the headend and the access network termination at the user's premises are described.
Polarographic and magnetic susceptibility study of various biferrocene compounds (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolarographic and magnetic susceptibility study of various biferrocene compoundsWilliam H. Morrison, Jr., Stephen Krogsrud, and David N. HendricksonCite this: Inorg. Chem. 1973, 12, 9, 1998–2004Publication Date (Print):September 1, 1973Publication History Published online1 May 2002Published inissue 1 September 1973https://pubs.acs.org/doi/10.1021/ic50127a009https://doi.org/10.1021/ic50127a009research-articleACS PublicationsRequest reuse permissionsArticle Views587Altmetric-Citations185LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ESTIMATING MEAN RUNOFF IN UNGAGED SEMIARID AREAS (1968)

ABSTRACT Relations of runoff to altitude may be denned for a hydrologically homogeneous region by using a limited number of streamflow records. Mean runoff from ungaged basins in this same region can then be computed on the basis of this derived relation. When these relations of runoff to altitude are applied to small areas, the runoff may be different from that indicated by the relation, because of local differences in geology, precipitation, vegetation, land slopes, and land use. Two methods are described for adjusting the relations for the effects of these variations; one based on a streamflow measurement at miscellaneous sites which is applicable to perennial streams, the other on measurement of two channel parameters which is applicable to either perennial or ephemeral streams.
Genomic binding by the <i>Drosophila</i> Myc, Max, Mad/Mnt transcription factor network (2003)

The Myc/Max/Mad transcription factor network is critically involved in cell behavior; however, there is relatively little information on its genomic binding sites. We have employed the DamID method to carry out global genomic mapping of the Drosophila Myc, Max, and Mad/Mnt proteins. Each protein was tethered to Escherichia coli DNA adenine-methyltransferase (Dam) permitting methylation proximal to in vivo binding sites in Kc cells. Microarray analyses of methylated DNA fragments reveals binding to multiple loci on all major Drosophila chromosomes. This approach also reveals dynamic interactions among network members as we find that increased levels of dMax influence the extent of dMyc, but not dMnt, binding. Computer analysis using the REDUCE algorithm demonstrates that binding regions correlate with the presence of E-boxes, CG repeats, and other sequence motifs. The surprisingly large number of directly bound loci ( approximately 15% of coding regions) suggests that the network interacts widely with the genome. Furthermore, we employ microarray expression analysis to demonstrate that hundreds of DamID-binding loci correspond to genes whose expression is directly regulated by dMyc in larvae. These results suggest that a fundamental aspect of Max network function involves widespread binding and regulation of gene expression.
Synthesis and characterization of colloidal ternary ZnCdSe semiconductor nanorods (2006)

For the synthesis of colloidal ternary ZnCdSe nanorods, CdSe nanorods were first prepared under a mixture of tetradecylphosphonic acid/trioctylphosphine oxide surfactants at 250 degrees C, and then ZnSe shell layer was grown onto CdSe nanorods at 180 degrees C, forming CdSeZnSe core/shell nanorods. Green-yellow emitting ternary ZnCdSe nanorods were obtained by a subsequent alloying process at 270 degrees C for 1-3 h through the diffusion of Zn ions into CdSe nanorods. The photoluminescence quantum yield (QY) of ZnCdSe nanorods was 5%-10%, which is higher than that from pristine CdSe nanorods (0.6%). The QY of these alloy nanorods depends on the alloying time and is discussed in terms of compositional disorders and defects produced by the alloying process. The Raman and time resolved photoluminescence spectroscopies were used to understand the detailed alloying process from CdSeZnSe core/shell to ZnCdSe alloy nanorods.
TDRSS Onboard Navigation System (TONS) flight qualification experiment (1994)

The National Aeronautics and Space Administration (NASA) Goddard Space Flight Center (GSFC) is currently developing an operational Tracking and Data Relay Satellite (TDRS) System (TDRSS) Onboard Navigation System (TONS) to provide realtime, autonomous, high-accuracy navigation products to users of TDRSS. A TONS experiment was implemented on the Explorer Platform/Extreme Ultraviolet Explorer (EP/EUVE) spacecraft, launched June 7, 1992, to flight qualify the TONS operational system using TDRSS forward-link communications services. This paper provides a detailed evaluation of the flight hardware, an ultrastable oscillator (USO) and Doppler extractor (DE) card in one of the TDRSS user transponders and the ground-based prototype flight software performance, based on the 1 year of TONS experiment operation. The TONS experiment results are used to project the expected performance of the TONS 1 operational system. TONS 1 processes Doppler data derived from scheduled forward-link S-band services using a sequential estimation algorithm enhanced by a sophisticated process noise model to provide onboard orbit and frequency determination and time maintenance. TONS 1 will be the prime navigation system on the Earth Observing System (EOS)-AM1 spacecraft, currently scheduled for launch in 1998. Inflight evaluation of the USO and DE short-term and long-term stability indicates that the performance is excellent. Analysis of the TONS prototype flight software performance indicates that realtime onboard position accuracies of better than 25 meters root-mean-square are achievable with one tracking contact every one to two orbits for the EP/EUVE 525-kilometer altitude, 28.5 degree inclination orbit. The success of the TONS experiment demonstrates the flight readiness of TONS to support the EOS-AM1 mission.
The Zinc Binuclear Cluster Activator AlcR Is Able to Bind to Single Sites but Requires Multiple Repeated Sites for Synergistic Activation of the alcA Gene in Aspergillus nidulans (1997)

The alcA gene which is part of the recently identified ethanol regulon, is one of the most strongly inducible genes in Aspergillus nidulans. Its transcriptional activation is mediated by the AlcR transactivator which contains a DNA-binding domain belonging to the C6 zinc binuclear cluster family. AlcR differs from the other members of this family by several features, the most striking characteristic being its binding to both symmetric and asymmetric DNA sites with the same apparent affinity. However, AlcR is also able to bind to a single site with high affinity, suggesting that unlike the other C6 proteins, AlcR binds as a monomer. In this report, we show that AlcR targets, to be functional in vivo, have to be organized as inverted or direct repeats. In addition, we show a strong synergistic activation of alcA transcription in which the number and the position of the AlcR-binding sites are crucial. The fact that the AlcR unit for in vitro binding is a single site whereas the in vivo functional unit is a repeat opens the question of the mechanism of the strong alcA transactivation. These results show that AlcR displays both in vitro and in vivo a new range of binding specificity and provides a novel example in the C6 zinc cluster protein family.
The protein phosphatase inhibitor calyculin A stimulates chemokine production by human synovial cells (1995)

Cultured human synovial fibroblasts express mRNA for the chemotactic cytokines (chemokines) interleukin-8 (IL-8), monocyte chemotactic protein 1 (MCP-1) and regulated upon activation normal T-cell expressed and presumably secreted (RANTES), when stimulated with IL-1 or tumour necrosis factor alpha (TNF alpha). Calyculin A, a potent type 1/2A protein serine/threonine phosphatase inhibitor, was used to examine the role of protein phosphatases in the regulation of chemokine gene expression. Calyculin A (1 nM) mimicked IL-1 by inducing IL-8 and MCP-1 mRNA expression in synovial cells. IL-8 mRNA was induced over a similar time period (1-6 h) in response to IL-1 or calyculin A, whereas MCP-1 mRNA was induced more rapidly (1-2 h) by calyculin A than by IL-1 (4-6 h). Expression of RANTES mRNA occurred in response to TNF alpha, but could not be induced by stimulation with calyculin A alone. These results suggest that inhibition of protein phosphatase type 1/2A may have a differential role in the regulation of the expression of each of the chemokine genes. Synovial fibroblasts also secreted IL-8 and IL-6 peptide when stimulated with either IL-1/TNF alpha or calyculin A. The amount of IL-8 and IL-6 peptide produced in response to calyculin A was significantly increased above that produced by untreated synovial cells, though it was much less than the amount induced by IL-1 or TNF alpha. Calyculin A also acted synergistically with IL-1 or TNF alpha to cause a 2-fold potentiation of IL-1- or TNF alpha-induced IL-8 mRNA and peptide and RANTES mRNA expression. These results suggest that although inhibition of a protein phosphatase may be able to regulate the magnitude of IL-1-induced chemokine gene expression, the IL-1 signal transduction pathway involves components in addition to phosphatase inhibition, possibly including the activation of a protein kinase, the action of which may be opposed by a protein phosphatase inhibited by calyculin A.
Project and Task Organization (2005)

Details organizations, hierarchical and non-hierarchical. Explains the critical role played by person to person communication in designing software and implementing systems. The pitfalls of staffing up are explored, including managing the early burn rate, and the essential personnel to be included on the initial teams. Verbal and written communication, including communication through body language and eye movement is discussed. The importance of completing the task is emphasized.
The Clinical Use of the MSLT and MWT (2005)

The studies examined in this review indicate that the MSL is sensitive to conditions expected to increase sleepiness. MSL are generally lower following sleep loss, following use of sedating medications, during wakefulness in the late night or early morning hours, and among patients with sleep disorders associated with excessive sleepiness such as narcolepsy or obstructive sleep apnea. However, the wide range in MSL makes it difficult to establish a specific threshold value for excessive sleepiness or to discriminate patients with sleep disorders from non-patients. Some of this variation may be attributable to methodological differences and some may be attributable to individual differences in sleep tendency (e.g., related to age). The studies analyzed in this review indicate that the MSL on both the MSLT and MWT does not discriminate well between patients with sleep disorders and normal populations. This is due to large SD as well as floor or ceiling effects in the tests. However, the MSL shows appropriate change from initial testing to subsequent testing following treatment or manipulations intended to alter sleepiness or alertness. Additionally the presence of two or more SOREMPs on the MSLT is a common finding in narcolepsy patients. However, SOREMPs are not exclusive to narcolepsy patients but are frequent in untreated sleep apnea
Accurate Molecular Mass Determination of Mycolic Acids by MALDI-TOF Mass Spectrometry (2001)

Mycolic acids, major and specific long-chain fatty (C70-C90) acid components of the mycobacterial cell envelope, were analyzed for the first time using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry operating in a reflectron mode. The various types of purified mycolates from representative mycobacterial species were analyzed using 2,5-DHB as matrix, because less than 10 pmol of mycolates was sufficient to obtain well-resolved mass spectra composed exclusively of pseudomolecular [M + Na]+ ions consistent with the structures deduced from the chemical analytical techniques applied to these molecules. Examination of the MALDI mass spectra demonstrated that the chain lengths of the various mycolates correlated with the growth rate of mycobacterial strains. Although slow growers, such as Mycobacterium tuberculosis and Mycobacterium ulcerans, produced a series of odd carbon numbers (C74-C82) of alpha-mycolic acids, rapid growers synthesized both odd and even carbon numbers. In addition, the main chain of oxygenated mycolic acids from slow growers were four to six carbon atoms longer than the corresponding alpha-mycolic acids, whereas rapid growers elaborated oxygenated homologues possessing the same chain lengths as their alpha-mycolic acids. Furthermore, a comparative analysis of the crude fatty acid mixtures from a wild-type strain of M. tuberculosis and its isogenic mutant effected in the synthesis of oxygenated mycolates by MALDI mass spectrometry revealed structural differences between the alpha-mycolates from the two strains. Thus, this technique appeared to be a rapid and highly sensitive technique for the analysis of mycolic acids, not only by providing accurate molecular masses and new structural information, but also by both reducing sample consumption and saving time.
Intensive coherent X-rays from multilayer mirrors (2002)

The results of experiment on further investigations of coherent X-ray emission produced by relativistic electrons passing through the periodic multilayer nanostructures well-known in X-ray optic as X-ray mirrors. Recently, we observed this new effect in the experiment carried out at the Tomsk "Sirius" synchrotron and found that a X-ray mirror might be used as a novel radiator for generation of monochromatic and narrow directed X-rays emitting at the large (Bragg) angle /spl theta//sub 0/=1.9/spl deg/ with respect to the mirror surface and at the angle /spl theta//sub D/=3.8/spl deg/ with respect to the electron beam direction. In this work we present the vertical spatial distributions and orientational dependencies of the spectra of this type of radiation. The results were also obtained at the Tomsk synchrotron with 500 MeV electrons and with two mirrors having the uniform and cluster graded periods. Both the spatial distributions and rocking-curves of radiation yield show the peaks having the narrow minima in the centre of the dependencies. The form and parameters of the dependencies allow to discus the mechanism of the novel effect.
Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex. (1997)

Glanzmann thrombasthenia is an inherited bleeding disorder characterized by absence or dysfunction of the platelet integrin alpha(IIb)beta3. Patient RM is a thrombasthenic variant whose platelets fail to aggregate in response to physiological agonists, despite the fact that they express abundant levels of alpha(IIb)beta3 on their surface. Binding of soluble fibrinogen or fibrinogen mimetic antibodies to RM platelets did not occur, except in the presence of ligand-induced binding site (LIBS) antibodies that transformed the RM integrin complex into an active conformation from outside the cell. Sequence analysis of PCR-amplified genomic DNA and platelet mRNA revealed a C2268T nucleotide substitution in the gene encoding the integrin beta3 subunit that resulted in an Arg724Ter mutation, producing a truncated protein containing only the first eight of the 47 amino acids normally present in the cytoplasmic domain. Functional analysis of both RM platelets and CHO cells stably expressing this truncated integrin revealed that the alpha(IIb)beta3Arg724Ter complex is able to mediate binding to immobilized fibrinogen, though downstream events, including cytoskeletally-mediated cell spreading and tyrosine phosphorylation of focal adhesion kinase, pp125FAK, fail to occur. These studies establish the importance of the membrane-distal portion of the integrin beta3 cytoplasmic domain in bidirectional transmembrane signaling in human platelets, and the role of integrin signaling in maintaining normal hemostasis in vivo.
Seems Familiar: An Algorithm For Inferring Spatial Familiarity Automatically (2012)

Abstract. Our level of spatial familiarity with a particular place determines our navigation and interaction around that particular space. Despite its importance, most location based services rarely consider a user&apos;s spatial familiarity when delivering their services. The lack of integration of a user’s spatial familiarity in location based services may be due to scarce work in automatic detection of a user’s spatial familiarity. In this work, following related studies in both psychology and geography, we propose a system that, given the user’s current location, can automatically infer the person’s level of spatial familiarity around the area he/she is currently in. The system first maps the user&apos;s location to a specific place and obtains information about the place and the surrounding areas. The features considered for the classification are: The number of visits and time of last visit made to the location he/she is currently in, the type of place and the spatial layout associated with the place, the relationships between the user and the
SENSORD/Stat: Combining sensor middleware with a statistical computing environment (2008)

On developing prototypes of multisensor surveillance systems, it is necessary to apply various types of statistical and numerical computing algorithms in analyzing sensor data. In addition, most of the algorithm implementation includes complex, numerical computing processes. Hence, implementing and applying various algorithms are tiresome tasks by application developers. To save time and manpower on creating the prototypes, we have been developing SENSORD/Stat, an extension of sensor-event-driven service coordination middleware (SENSORD). In the SENSORD/Stat system, SENSORD cooperatively works with R, which is an open source statistical computing and graphic environment. Using both spatio-temporal sensor data management of SENSORD and statistical and numerical analyses of R, developers can rapidly create prototypes of indoor multisensor surveillance systems. In this paper, we show the outline of SENSORD/Stat and a prototype of a room temperature monitoring system as a preliminary result of SENSORD/Stat.
Microfluidic chaotic stirrer utilizing induced-charge electro-osmosis (2007)

Recently, there has been a growing interest in using induced electro-osmosis to pump fluids in microfluidic devices. We show that induced electroosmosis can also be used to promote stirring and chaotic advection. To this end, we study theoretically a stirrer in which the flow patterns are alternated in time. We first analyze an idealized embodiment of the stirrer that admits a simple analytical solution for the flow patterns. The stirrer consists of a concentric annulus whose outer surface is defined by an array of electrodes that provide a spatially varying potential distribution. The resulting electric field induces quadruple electro-osmotic flow around the inner cylinder. By timewise alternating the potential distribution around the outer cylinder, we induce chaotic advection in the cavity. Subsequently, we carry out numerical simulations for a more realistic design that can be readily constructed, and demonstrate that it is possible to induce chaotic advection also in this case.