gebhart/patrepeval huggingface dataset:
Systemic Administration of Human Adipose-Derived Stem Cells Reverts Nociceptive Hypersensitivity in an Experimental Model of Neuropathy (2012)

Over the last decade, it has been proved that mesenchymal stem cells (MSCs) elicit anti-inflammatory effects. MSCs from adipose tissue (hASCs) differentiate into cells of the mesodermal lineage and transdifferentiate into ectodermal-origin cells. Although there are various etiologies to chronic pain, one common feature is that painful states are associated with increased inflammation. We believe in hASCs as a therapeutic tool also in pathologies involving neuroinflammation and neuronal tissue damage. We have investigated the effect of hASCs injected in a model of neuropathic pain [(mouse sciatic nerve chronic constriction injury (CCI)]. hASCs from 5 donors were characterized, and no major differences were depicted. hASCs were cryopreserved and grown on demand. About 1×10(6), 3×10(6), and 6×10(6) hASCs were intravenously injected into normal immunocompetent mice. No mouse died, and no macroscopic toxicity or behavioral changes were observed, confirming the safety of hASCs. hASCs, intravenously (i.v.) injected into C57BL/6 mice when the neuropathic pain was already established, induced a significant reduction in mechanical allodynia and a complete reversion of thermal hyperalgesia in a dose-response fashion, already 1 day after administration. Moreover, the hASCs effect can be boosted by repeated administrations, allowing a prolonged therapeutic effect. Treatment decreased the level of the CCI-induced proinflammatory cytokine interleukin (IL)-1β and activated the anti-inflammatory cytokine IL-10 in the lesioned nerve. hASCs treatment also restored normal inducible nitric oxide synthase expression in the spinal cord of CCI animals. Our data suggest that hASCs are worthy of further studies as an anti-inflammatory therapy in the treatment of neuropathic pain or chronic inflammatory diseases.
Tumor-Associated Macrophages Recruit CCR6+ Regulatory T Cells and Promote the Development of Colorectal Cancer via Enhancing CCL20 Production in Mice (2011)

TAMs recruit CCR6(+) Treg-cells to tumor mass and promote its development via enhancing the production of CCL20 in a CRC mouse model.
Quadratic spline interpolator (1996)

A simple system is proposed which generates a quadratic spline function interpolating a given discrete-time signal. It works as a D-A converter which is free from phase distortions and whose output is smooth. The output is constructed as two-fold integration of a staircase signal. A kind of sampled data feedback is employed to stabilize the system. Its circuit is mainly composed of a pair of D-A and A-D converter chips and two analogue integrators. This hardware complexity is about a quarter of current systems.
Analog Analog Correlator/Convolver (1978)

A new LSI discrete-time signal processing device is presented, capable of performing the convolution or correlation of two analog signals at clock rates up to 5 MHz.
Effect of chili pepper (Capsicum frutescens) ingestion on plasma glucose response and metabolic rate in Thai women. (2003)

Within 30 min after consumption of 5 g of Capsicum frutescens, plasma glucose level during the absorption period was significantly inhibited. The metabolic rate was also immediately increased after ingestion and sustained up to 30 min.
CAN assessment in time-critical cyclic applications through Petri net model (2002)

The authors discuss problems relating to use of the CAN (controller area network) fieldbus in time-critical process control applications. Certain characteristics of the CSMA/CD protocol, such as the reduced size of the frames with simplified headers and the use of an approach based on nondestructive collisions, allow optimal exploitation of the communication bandwidth. Moreover, the use of a priority-based approach to solve collisions provides a form of implicit scheduling, similar to the rate monotonic algorithm, which allows traffic to be organized correctly, according to the time constraints of the various variables. In the paper, after presenting the main features of the CAN, the problem of correct traffic scheduling is dealt with. A system model based on Petri nets is presented and evaluated. The results of the simulations performed show that CAN is suitable for several time-critical applications.
Proteolytic processing of the insulin receptor beta subunit is associated with insulin-induced receptor down-regulation (1991)

This report describes the use of an antibody directed against the carboxyl terminus of the insulin receptor beta subunit to assess the fate of the insulin receptor protein over the time course of insulin-induced receptor down-regulation. The insulin receptor beta subunit is lost from the cellular membranes of insulin-treated 3T3-C2 fibroblasts with a time course superimposable with the insulin-induced loss of cellular insulin binding activity. Concomitant with the time-dependent loss of the intact beta subunit from the membranes, a 61,000-Da fragment of the insulin receptor beta subunit accumulates in the cytosol of the cells in a time-dependent manner. The insulin-induced loss of the intact beta subunit from the cellular membranes is inhibited by cycloheximide. Chloroquine and the thiol protease inhibitors leupeptin and E-64 inhibit the insulin-induced loss of the intact beta subunit from the membranes and induce an accumulation of the intact subunit in the membranes. However, in the presence of leupeptin, E-64, or chloroquine, the insulin-induced loss of insulin binding activity occurs normally. These data indicate that down-regulation results in the loss of the intact beta subunit from the cellular membranes with the production of a fragment of the beta subunit in the cytosol. The protease responsible for the generation of the fragment is a thiol protease which requires acidic conditions. Since the insulin-induced proteolysis of the beta subunit can be totally inhibited under conditions where the insulin-induced loss of insulin binding activity proceeds normally, the proteolysis of the beta subunit is a process which is separate and distinguishable from the insulin-induced loss of insulin binding activity.
ZoneTag's Collaborative Tag Suggestions: What is This Person Doing in My Phone? (2008)

We describe ZoneTag, a camera phone application that allows users to capture, annotate, and share photos directly from their phone. We describe the simple mechanism for deriving tag suggestions and the ensuing interaction design for presenting these suggestions to the user. We also discuss quantitative and qualitative results from an 18-months deployment of ZoneTag, emphasizing the way people use and understand tag suggestions. In addition, we highlight several emerging issues that could play an important role in the collaborative tagging for multimedia as well as other resources. While the quantitative study on the use of the suggested tags feature implies clear benefits for tag suggestions, a set of qualitative studies imply that while tag suggestions are helpful, there are multiple issues that arise and require careful consideration.
Harmonic impedance measurement using voltage and current increments from disturbing loads (2002)

A device has been developed to measure the harmonic impedances of power network by using harmonic voltage and current increments at the point of common coupling between the network and a disturbing load. The key problem in the implementation of the method is the synchronization of phasors sampled asynchronously and at different times. This kind of synchronization is linked to the frequency measurement. A small error in the frequency will cause a great deviation of the impedance measurement. A formulation is given here to evaluate the error on the impedance in each individual measurement (event), and a statistical method is proposed to achieve a relatively high accuracy in the source impedance estimation. Laboratory and field tests results are both discussed as well as verified with the harmonic emission level estimation of the disturbing load.
Mitochondrial DNA polymorphisms in Italy I. Population data from Sardinia and Rome (1986)

The polymorphisms of human mitochondrial DNA were studied in about 150 Sardinians from Cagliari and 100 other Italians living in Rome, using total blood cell DNA and the following restriction enzymes: HpaI, BamHI, HaeII, MspI, AvaII and HincII. 1. Seven different new morphs have been identified, one for HaeII, four for AvaII and two for HincII. 2. 16 and 17 mtDNA types were observed in the Sardinian and Roman samples, respectively. Of these only seven were shared by both groups. The morphs BamHI-3, MspI-4 and AvaII-9 were found associated at a frequency (10.0%) much higher than expected (0.17%). 3. Sardinians can be differentiated from the other Italians for a higher frequency of both morph AvaII-1 (P less than 0.05) and type 1 (2-1-1-1-1) (P approximately less than 0.03), and for a lower intragroup heterogeneity (0.52 v. 0.61). 4. The Italian sample on the whole can also be differentiated from the Caucasian group previously examined for a lower frequency of BamHI morph 2 (P Yates less than 0.01), a higher frequency of HaeII morph 1 (P Yates less than 0.02) and for the presence at a non-negligible incidence (5 individuals out of 229) of the new type 57-2 (2-3-1-4-13-2). The data indicate that mtDNA polymorphisms have not only proved to be a useful tool in detecting differences among major human groups but they can also differentiate populations within the same major ethnic division.
Computational model for prediction of shaping with FJP and experimental validation (2002)

A computer program is presented for computing material removal from spot-footprints, which is used to design a nozzle ideal for shape corrections, and to predict large-area removal. This removal can be in the ductile regime.
Bactericidal activity of fractionated granule contents from human polymorphonuclear leukocytes: antagonism of granule cationic proteins by lipopolysaccharide (1979)

Granule extracts from human polymorphonuclear leukocytes (PMN) were prepared with 0.2 M (pH 4.0) acetate. A fraction (valley AB) with distinctive bactericidal activity against cell wall mutants of Salmonella typhimurium LT-2 was obtained after fractionation of the granule extracts by Sephadex G-100 column chromatography. The smooth parent LT-2 strain was less sensitive to the bactericidal action. Susceptibility of the rough mutants to bactericidal action increased as sugar residues decreased in the lipopolysaccharide (LPS) (Re greater than Rd2 greater than Rd1 greater than Rc greater than Ra). Cationic protein(s) responsible for bactericidal activity could be selectively removed from the fraction by absorption with whole LT-2 cells or purified LPS. Loss of cationic protein species was confirmed by cationic polyacrylamide gel electrophoresis. Purified LPS from LT-2 or the deep rough mutant TA2168 inhibited the antimicrobial activity of the killing fraction in in vitro assays. A minor protein species (vAB1) from the valley AB fraction had an apparent molecular weight of 36,000 to 37,000 and represented a major bactericidal activity of the fraction. Small amounts of the isolated vAB1 protein were bactericidal for the smooth parent LT-2 strain.
WarpMap: Accurate and Efficient Indoor Location by Dynamic Warping in Sequence-Type Radio-Map (2016)

Radio-map based method has been widely used for indoor location and navigation, but remaining key challenges are: 1) laborious efforts to calibrate a fine-grained radio-map, and 2) the locating result inaccuracy and not robust problems due to random signal strength (RSS) noises. An efficient way to overcome these problems is to collect RSS signatures along indoor paths and utilize sequence matching to enhance the location robustness. But, due to problems of indoor path combinational explosion, random RSS loss during movement, and moving speed disparity during online and offline phases, how to exploit sequence matching in radio-map remains difficult. This paper proposes WarpMap, an efficient sequence-type radio-map model and an accurate indoor location method by dynamic warping. Its distinct features include: 1) an undirected graph model (Trace-graph) for efficiently calibrating and storing sequence-type radio-map, which overcomes the path combinational explosion and RSS miss-of-detection problems; 2) an efficient sub-sequence dynamic time warping (SDTW) algorithm for accurate and efficient on-line locating. We show SDTW can tolerate random RSS disparities at discrete points and handle the moving speed differences in on-line and offline phases. The impacts of different warping distance functions, RSS preprocessing techniques were also investigated. Extensive experiments in office environments verified the efficiency and accuracy of WarpMap, which can calibrated within ten minutes by one person for 1100m2 area and provides overall nearly 20% accuracy improvements than the state-of-the-art of radio-map method.
Heterogeneity analysis of breast cancer families by using age at onset as a covariate. (1992)

An extension of the usual mixture model of heterogeneity (two family types, one with and one without linkage) is proposed by introducing age at onset as a covariate. The extended model defines age-dependent penetrances where the exact parametrization of age-at-onset distributions depends on the given genotype and family type (linked or unlinked). This extension was applied to breast cancer families. We postulated that the mean age at onset in individuals affected by the linked gene was lower than the mean age at onset in all other affected individuals. Linkage heterogeneity for breast cancer families was detected at a significance level of .003.
Mars Express Interplanetary Navigation from Launch to Mars Orbit Insertion: The JPL Experience (2004)

The National Aeronautics and Space Administration (NASA) Jet Propulsion Laboratory (JPL) played a significant role in supporting the safe arrival of the European Space Agency (ESA) Mars Express (MEX) orbiter to Mars on 25 December 2003. MEX mission is an international collaboration between member nations of the ESA and NASA, where NASA is supporting partner. JPL's involvement included providing commanding and tracking service with JPL's Deep Space Network (DSN), in addition to navigation assurance. The collaborative navigation effort between European Space Operations Centre (ESOC) and JPL is the first since ESA's last deep space mission, Giotto, and began many years before the MEX launch. This paper discusses the navigational experience during the cruise and final approach phase of the mission from JPL's perspective. Topics include technical challenges such as orbit determination using non-DSN tracking data and media calibrations, and modeling of spacecraft physical properties for accurate representation of non-gravitational dynamics. Also mentioned in this paper is preparation and usage of DSN Delta Differential Oneway Range ((Delta)DOR) measurements, a key element to the accuracy of the orbit determination.
Detection of JC Virus-Specific Cytotoxic T Lymphocytes in Healthy Individuals (2004)

The polyomavirus JC (JCV) infects 85% of healthy individuals, and its reactivation in a limited number of immunosuppressed people causes progressive multifocal leukoencephalopathy (PML), a severe demyelinating disease of the central nervous system. We hypothesized that JCV-specific cytotoxic T lymphocytes (CTLs) might control JCV replication in healthy individuals, blocking the evolution of PML. Using 51Cr release and tetramer staining assays, we show that 8 of 11 HLA-A*0201+ healthy subjects (73%) harbor detectable JCV-specific CD8+ CTLs that recognize one or two epitopes of JCV VP1 protein, the HLA-A*0201-restricted VP1p36 and VPp1100 epitopes. We determined that the frequency of JCV VP1 epitope-specific CTLs varied from less than 1/100,000 to 1/2,494 peripheral blood mononuclear cells. More individuals had JCV VP1-specific than cytomegalovirus-specific CTLs (8 of 11 subjects [73%] versus 2 of 10 subjects [20%], respectively). These results show that a CD8+-T-cell response against JCV is commonly found in immunocompetent people and suggest that these cells might protect against the development of PML.
The relationship between river flow and entry to the Aberdeenshire Dee by returning adult Atlantic salmon (1994)

One hundred and nine returning adult salmon were radio‐tagged in the estuary of the Aberdeenshire Dee, Scotland between February and August 1985 to 1989 and the times when 62 fish entered the river were recorded. Elapsed times between tagging and river entry were significantly greater during periods of lower than average river flows in all months where there were sufficient data to allow statistical comparison. The degree of association between river entry and particular levels of river discharge rate varied seasonally. The proportion of days associated with river entry declined at the lower end of the range of flows available to tagged fish in the summer months. Absolute levels of river discharge played a significant role in modifying the response of salmon to changing flows. During periods of lower than average seasonal flow, river entry was closely associated with days when flow had increased since the previous day. During periods of higher than average flow, river entry was not significantly associated with such periods of increased flow. The results suggest that models which relate river entry by salmon to absolute discharge rates alone are unlikely to be generally reliable.
Impact of surface morphology above threading dislocations on leakage current in 4H-SiC diodes (2012)

The nano-scale pits above the threading dislocations were found to be in the same location as the leakage current points in Schottky barrier diodes and junction barrier Schottky diodes. This study compared the leakage current of 1.2 kV, 200 A diodes with and without nano-scale pits. The leakage current in diodes without nano-scale pits was lower than those in diodes with pits. In the diodes without nano-scale pits, the leakage currents were generated at step-bunching area and the leakage current at the threading dislocations was not observed.
Microchannel Spatial Light Modulator Using Liquid Crystal for Modulating Material (1990)

Optical parallel processing is an attractive technique for treating today's vast quantities of information in parallel. In this field, a spatial light modulator which modulates the light in two dimensions is required. We have developed a microchannel spatial light modulator (MSLM) using LiNbO 3 for a modulating material. However, it has physical limitations in readout light intensity, the spatial resolution and operating speed. In order to improve the characteristics of MSLM, liquid crystal (LC) is adopted for the modulating material. In this paper, the structure of the device and the operating principle are explained. The basic experimental results of the device are also shown.
A data-transition look-ahead DFF circuit for statistical reduction in power consumption (1998)

A new data-transition look-ahead DFF (DL-DFF) that reduces the power consumption of CMOS LSI's is proposed. The power consumption is reduced in accordance with the data-transition probability. The main feature of the DL-DFF is that the clock signal is deactivated when there are no data transitions. This reduces the power consumption when the data-transition probability is low. The power consumption of a DL-DFF is compared to that of a conventional one by measuring a test chip fabricated using a 0.25-/spl mu/m CMOS/SIMOX process. It is found that a DL-DFF consumes less power than a conventional one when the data-transition probability is under 60%. For example, when the data-transition probability is 25%, it consumes 29% less power. Moreover, some suitable applications of a DL-DFF are presented.
Robust ECG Signal Classification for the Detection of Atrial Fibrillation Using Novel Neural Networks (2017)

Deep learning has emerged as an effective tool for handling complex data analysis with minimal pre-and post-processing.
Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation (2016)

The covalent conjugation of ubiquitin-fold modifier 1 (UFM1) to proteins generates a signal that regulates transcription, response to cell stress, and differentiation. Ufmylation is initiated by ubiquitin-like modifier activating enzyme 5 (UBA5), which activates and transfers UFM1 to ubiquitin-fold modifier-conjugating enzyme 1 (UFC1). The details of the interaction between UFM1 and UBA5 required for UFM1 activation and its downstream transfer are however unclear. In this study, we described and characterized a combined linear LC3-interacting region/UFM1-interacting motif (LIR/UFIM) within the C terminus of UBA5. This single motif ensures that UBA5 binds both UFM1 and light chain 3/γ-aminobutyric acid receptor-associated proteins (LC3/GABARAP), two ubiquitin (Ub)-like proteins. We demonstrated that LIR/UFIM is required for the full biological activity of UBA5 and for the effective transfer of UFM1 onto UFC1 and a downstream protein substrate both in vitro and in cells. Taken together, our study provides important structural and functional insights into the interaction between UBA5 and Ub-like modifiers, improving the understanding of the biology of the ufmylation pathway.
Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain. (1994)

We have cloned a second class of inward rectifier potassium channels, designated MB-IRK2, from a mouse brain cDNA library. The amino acid sequence of this clone shares 70% identity with the mouse IRK1. Xenopus oocytes injected with cRNA derived from MB-IRK2 expressed a K+ current, which showed inward rectifying channel characteristics similar to the MB-IRK1 current. In contrast to the MB-IRK1 current, however, the MB-IRK2 current exhibited significant inactivation during hyperpolarizing pulses. In patch clamp experiments with 140 mM K+ in the pipette, the single channel conductance of MB-IRK2 was 34.2 +/- 2.1 picosiemens (n = 5), a value significantly larger than that of MB-IRK1 (22.2 +/- 3.0 picosiemens, n = 5). Consistent with the whole cell current, the steady-state open probability (Po) of the MB-IRK2 channel decreased with hyperpolarization, whereas that of the MB-IRK1 remained constant. Northern blot analysis revealed the mRNA for MB-IRK2 to be expressed in forebrain, cerebellum, heart, kidney, and skeletal muscle. In the brain, the abundance of mRNA for MB-IRK2 was much higher in cerebellum than in forebrain and vice versa in the case of MB-IRK1. These results demonstrate that the IRK family is composed of multiple genes, which may play heterogenous functional roles in various organs, including the central nervous system.
Answering Queries using Templates with Binding Patterns (1995)

) Anand Rajaraman Yehoshua Sagiv Jeffrey D. Ullman Department of Computer Science Stanford University ABSTRACT When integrating heterogeneous information resources, it is often the case that the source is rather limited in the kinds of queries it can answer. If a query is asked of the entire system, we have a new kind of optimization problem, in which we must try to express the given query in terms of the limited query templates that this source can answer. For the case of conjunctive queries, we show how to decide with a nondeterministic polynomial-time algorithm whether the given query can be answered. We then extend our results to allow arithmetic comparisons in the given query and in the templates. I. Motivation A data-integration system such as Tsimmis (Papakonstantinou, Garcia, and Widom [1994], Chawathe et al. [1994]) translates information sources of arbitrary type into a common data model and language. If a source is an SQL database, then its interface with the Tsimmis s...