gebhart/patrepeval huggingface dataset:
The Axially-Stratified-Charge Engine (1982)

<div class="htmlview paragraph">A method to stratify the fuel-air mixture along the cylinder axis of engines is described. Axial stratification, with the richest mixture near the top of the combustion chamber and the leanest mixture near the piston top, was obtained by imparting swirl to the intake air and by injecting fuel into the inlet port just before the end of the intake stroke. Axial stratification was developed in both single and multi-cylinder engines over the range of operating conditions tested.</div> <div class="htmlview paragraph">A production four-cylinder engine modified to operate with axially-stratified-charge, showed: increased combustion stability and tolerance to dilute mixtures; decreased fuel consumption; similar HC and CO emissions; lower NO emissions and octane requirement when compared with the unmodified engine operated at the same overall equivalence ratio.</div>
Driven Liquids (1999)

Article MetricsDownloadsCitationsNo data available.01234JulAugSepOctNovDec2000Total6 Months12 MonthsTotal number of downloads for the most recent 6 whole calendar months.
Molecular changes in the multistage pathogenesis of head and neck cancer (2011)

Head and neck squamous cell carcinomas (SCCHN) arise in the mucosa of the upper aerodigestive tract at multiple anatomic sites. While tobacco and alcohol exposure remain the primary risk factors for this malignancy, infection with the human papilloma virus is emerging as a major contributing factor to cancers that arise primarily in the oropharynx. Despite therapeutic advances, survival has remained relatively unchanged over the past few decades. Increased understand of the cellular and molecular biology of these cancers will improve our understanding of this malignancy and facilitate the development of more effective therapeutic strategies. Alterations that have been studied to date include genetic and epigenetic changes. While the epidermal growth factor receptor (EGFR) is the only established molecular therapeutic target, other proteins and pathways are under active investigation to determine their contribution to SCCHN carcinogenesis and progression.
Synthesis and Structure of 4-Substituted Decahydroisoquinoline Derivatives (1968)

Four possible racemates of 4-hydroxymethyldecahydroisoquinolines, hitherto unknown in the literature, were synthesized and their stereochemistry was specified and characterized. Hydrochloride salts of their benzoylesters were also prepared and their local anesthetic activity was tested, but none was proved to be useful.
Thermal Decomposition Rates of Carbonates in Oil Shale (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal Decomposition Rates of Carbonates in Oil ShaleE. E. Jukkola, A. J. Denilauler, H. B. Jensen, W. I. Barnet, and W. I. R. MurphyCite this: Ind. Eng. Chem. 1953, 45, 12, 2711–2714Publication Date (Print):December 1, 1953Publication History Published online1 May 2002Published inissue 1 December 1953https://pubs.acs.org/doi/10.1021/ie50528a046https://doi.org/10.1021/ie50528a046research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Nanoparticle PEBBLE Sensors in Live Cells and In Vivo (2009)

Nanoparticle sensors have been developed for real-time imaging and dynamic monitoring, both in live cells and in vivo, of molecular and ionic components, constructs, forces, and dynamics observed during biological, chemical, and physical processes. With their biocompatible small size and inert matrix, nanoparticle sensors have been successfully applied to noninvasive real-time measurements of analytes and fields in cells and in rodents, with spatial, temporal, physical, and chemical resolution. This review describes the diverse designs of nanoparticle sensors for ions and small molecules, physical fields, and biological features, as well as the characterization, properties, and applications of these nanosensors to in vitro and in vivo measurements. Their floating as well as localization abilities in biological media are captured by the acronym PEBBLE: photonic explorer for bioanalysis with biologically localized embedding.
User-oriented criteria for the selection of DSS software (1985)

Both the composition of the selection team and the choice of evaluation criteria should reflect the end-user orientation of DSS software.
Evaluating Operational Specifications of Point-of-Care Diagnostic Tests: A Standardized Scorecard (2012)

The expansion of HIV antiretroviral therapy into decentralized rural settings will increasingly require simple point-of-care (POC) diagnostic tests that can be used without laboratory infrastructure and technical skills. New POC test devices are becoming available but decisions around which technologies to deploy may be biased without systematic assessment of their suitability for decentralized healthcare settings. To address this, we developed a standardized, quantitative scorecard tool to objectively evaluate the operational characteristics of POC diagnostic devices. The tool scores devices on a scale of 1-5 across 30 weighted characteristics such as ease of use, quality control, electrical requirements, shelf life, portability, cost and service, and provides a cumulative score that ranks products against a set of ideal POC characteristics. The scorecard was tested on 19 devices for POC CD4 T-lymphocyte cell counting, clinical chemistry or hematology testing. Single and multi-parameter devices were assessed in each of test categories. The scores across all devices ranged from 2.78 to 4.40 out of 5. The tool effectively ranked devices within each category (p<0.01) except the CD4 and multi-parameter hematology products. The tool also enabled comparison of different characteristics between products. Agreement across the four scorers for each product was high (intra-class correlation >0.80; p<0.001). Use of this tool enables the systematic evaluation of diagnostic tests to facilitate product selection and investment in appropriate technology. It is particularly relevant for countries and testing programs considering the adoption of new POC diagnostic tests.
Treatment of heroin-dependent persons with antagonists: current status. (1981)

Naltrexone is an important new pharmacologic adjunct to the treatment of heroin dependence. The development of naltrexone has been nurtured in the mature recognition that simple detoxification or simple opiate replacement therapy is not appropriate for every heroin addict. Our current data indicate that naltrexone is safe and effective. Its use may be limited to a minority of addicts, those who are highly motivated and opiate free, because patient compliance has been a major problem with which clinicians using naltrexone have had to contend. Patient compliance is a problem, because there are no immediate consequences to the patient for stopping his naltrexone regimen. Side effects from naltrexone have been minimal and have occurred in a minority of patients. They consist primarily of gastrointestinal symptoms, including nausea and occasionally abdominal pain.
Components of Podophyllin. V. The Constitution of Podophyllotoxin<sup>1</sup> (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComponents of Podophyllin. V. The Constitution of Podophyllotoxin1Jonathan L. Hartwell and Anthony W. SchreckerCite this: J. Am. Chem. Soc. 1951, 73, 6, 2909–2916Publication Date (Print):June 1, 1951Publication History Published online1 May 2002Published inissue 1 June 1951https://pubs.acs.org/doi/10.1021/ja01150a143https://doi.org/10.1021/ja01150a143research-articleACS PublicationsRequest reuse permissionsArticle Views492Altmetric-Citations96LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Co-designing a scalable quantum computer with trapped atomic ions (2016)

Abstract The first generation of quantum computers are on the horizon, fabricated from quantum hardware platforms that may soon be able to tackle certain tasks that cannot be performed or modelled with conventional computers. These quantum devices will not likely be universal or fully programmable, but special-purpose processors whose hardware will be tightly co-designed with particular target applications. Trapped atomic ions are a leading platform for first-generation quantum computers, but they are also fundamentally scalable to more powerful general purpose devices in future generations. This is because trapped ion qubits are atomic clock standards that can be made identical to a part in 10 15 , and their quantum circuit connectivity can be reconfigured through the use of external fields, without modifying the arrangement or architecture of the qubits themselves. In this forward-looking overview, we show how a modular quantum computer with thousands or more qubits can be engineered from ion crystals, and how the linkage between ion trap qubits might be tailored to a variety of applications and quantum-computing protocols.
Interaction of Haemophilus influenzae with human erythrocytes and oropharyngeal epithelial cells is mediated by a common fimbrial epitope (1988)

The role of fimbriae in the adherence of Haemophilus influenzae to oropharyngeal epithelial cells and the hemagglutination (HA) of human Anton-positive erythrocytes was examined. HA of bacteria was lost after shearing. Fimbriae purified from the extracellular fluid caused HA and bound to oropharyngeal epithelial cells, as analyzed with immunoperoxidase staining, in a way which was similar to the adherence of bacteria to these cells: binding was over the entire surface of the cells and showed cell-to-cell variation. The specific role of fimbriae in HA and adherence was further examined by inhibition experiments with monoclonal antibodies elicited against the isolated fimbriae. These monoclonal antibodies bound along the entire length of the fimbriae, as seen by immunogold electron microscopy. The monoclonal antibodies and their Fab fragments inhibited HA (reduction in titer from 1:512 to 1:128 and 1:64, respectively) and inhibited the adherence of the homologous H. influenzae strain and of three of eight heterologous H. influenzae strains to oropharyngeal epithelial cells. These results indicate that fimbriae are involved in adherence and HA and that the binding site for the monoclonal antibodies on the fimbriae is not common on all strains.
Comparison of fusion assessment techniques: computer-assisted versus manual measurements (2008)

Although osseous fusion after arthrodesis remains difficult to assess, new computer-assisted techniques may remove the subjectivity generally associated with assessing fusion.
<title>Recording and processing of silver halide color holograms</title> (1995)

Color holograms recorded in panchromatic, single-layer ultra-high-resolution silver-halide emulsions have been previously reported. Color reflection holography presents no problems as regards the geometry of the recording setup, but the final result is highly dependent on the recording material used. The processing of such emulsions is critical in order to obtain high diffraction efficiency and good color rendering. In particular, preventing emulsion shrinkage is extremely important. The recording procedure and the processing steps will be described.
Chloroquine reduces whole body proteolysis in humans (1994)

The antimalaric drug chloroquine is a well known inhibitor of lysosomal proteolysis in vitro. The present study tests the hypothesis that therapeutic doses of the drug decrease proteolysis also in vivo in humans. Leucine kinetics were determined in 20 healthy volunteers given 12 and 1.5 h before the studies 250 and 500 mg, respectively, of chloroquine phosphate (n = 10) or similar tablets of placebo (n = 10). Chloroquine reduced the rates of leucine appearance, a measure of whole body proteolysis, from 2.45 +/- 0.08 to 2.19 +/- 0.08 mumol.kg-1.min-1 (P = 0.038) and those of nonoxidative leucine disposal, an estimate of whole body protein synthesis, from 2.16 +/- 0.08 to 1.95 +/- 0.06 mumol.kg-1.min-1 (P = 0.050). The drug resulted also in a marginally significant (P = 0.051) decrement in the plasma concentrations of glucose. The effects of chloroquine on protein turnover might be potentially useful in counteracting protein wasting complicating several catabolic diseases, whereas those on glucose metabolism can explain the sporadic occurrence of severe hypoglycemic episodes in malaria patients chronically treated with this drug.
Immunoenzymatic method for detection of terminal deoxynucleotidyl transferase by light and electron microscopy. (1987)

Methods for using rabbit polyclonal and mouse monoclonal antibodies to detect terminal deoxynucleotidyl transferase (TdT) in human leukemia lines were developed. Use of 1% paraformaldehyde in 0.1 M Na cacodylate buffer, pH 7.6, as a fixative provides a procedure that can be used for immunofluorescence, immunoalkaline phosphatase (APAAP), or horseradish peroxidase conjugate detection procedures in these cell lines. The peroxidase procedure can also be used for electron microscopy, clearly demonstrating nuclear localization of TdT in interphase nuclei of TdT-positive cells.
Pharmacologic induction of fetal hemoglobin: raising the therapeutic bar in sickle cell disease (2001)

The favorable effects of high levels of fetal hemoglobin (Hb F) in sickle cell disease have been recognized for several decades. This has been an important incentive for the development of therapeutic agents that increase Hb F production. 5-Azacytidine, the first such agent in clinical use, was proposed based on a molecular understanding of the role of DNA methylation in globin gene regulation. Controversy over the mechanism of Hb F induction by 5-azacytidine led to the identification of hydroxyurea as another agent that can increase Hb F production. Although the clinical benefit of hydroxyurea has been demonstrated in a randomized clinical trial, greater increases in Hb F are clearly needed for optimal therapeutic effect. Butyrates also increase Hb F levels, and their use in combination with hydroxyurea appears to be synergistic. Now that multiple therapeutic agents are available for Hb F induction, the use of combination therapy to increase Hb F levels sufficiently to prevent all the complications of sickle cell disease has become a realistic goal.
Study of emitter structures for InSb thermal diodes (2004)

We reported earlier that introduction of potential barrier structures into emitter and collector regions of a thermoelectric material plate (thermal diode) greatly enhances effective figure of merit. Up to eight times increase was observed with corresponding efficiencies up to 40% of ideal Carnot cycle or an effective ZT of 3.2. Absolute efficiencies up to 18% were observed. Here we report a systematic study of emitter parameters that influence InSb thermal diode performance.
Plasma vascular endothelial growth factor, soluble VEGF receptor FLT-1, and von Willebrand factor in glaucoma (2002)

The pathogenesis of optic nerve damage in both NTG and POAG may be associated with abnormal vascular permeability and endothelial damage/dysfunction, as indicated by abnormal plasma VEGF and vWf levels in these patients.
Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy (2004)

Prolactin (PRL) exerts its biological effects mainly by activating the Janus kinase/signal transducer and activator of transcription 5 (JAK/STAT5) signaling pathway. We have recently demonstrated that PRL also stimulates the insulin receptor substrates/phosphatidylinositol 3-kinase (IRSs/PI3K) and SH2-plekstrin homology domain (SHC)/ERK pathways in islets of neonatal rats. In the present study, we investigated the involvement of the PI3K and MAP kinase (MAPK) cascades in islet development and growth in pregnant rats. The protein expression of AKT1, p70S6K and SHC was higher in islets from pregnant compared with control rats. Higher basal levels of tyrosine phosphorylation were found in classic transducers of insulin cell signaling (IRS1, IRS2 and SHC). Increased levels of threonine/tyrosine phosphorylation of ERK1/2 and serine phosphorylation of AKT and p70S6K were also detected. To assess the participation of PRL in these phenomena, pregnant and control rats were treated with an antisense oligonucleotide to reduce the expression of the PRL receptor (PRLR). Phosphorylation of AKT was reduced in islets from pregnant and control rats, whereas p70S6K protein levels were reduced only in islets from treated pregnant rats. Finally, glucose-induced insulin secretion was reduced in islets from pregnant but not from control rats treated with the PRLR antisense oligonucleotide. In conclusion, downstream proteins of the PI3K (AKT and p70S6K) and MAPK (SHC and ERK1/2) cascades are regulated by PRL signaling in islets from pregnant rats. These findings indicate that these pathways participate in the increase in islet mass and the sensitivity to glucose during pregnancy.
Publications nouvelles (1941)

Febvre Lucien, Perrin Ch.-Edmond. Publications nouvelles. In: Annales d'histoire sociale. 3ᵉ année, N. 3-4, 1941. pp. 178-179.
A monoclonal antibody reactive with human eosinophils (1986)

EO-1, an IgGl murine monoclonal antibody raised against human eosinophilic leukemia cells, reacts with eosinophils, basophils, platelets, and a few (2%) mononuclear cells but not with neutrophils. In the bone marrow, mature and immature eosinophils and basophils express the EO-1 antigen, whereas immature myeloid cells do not. The distribution of EO-1 antigen on leukemic cells is concordant with this finding, ie, typical myeloid lines (HL-60, KG-1, and ML-1) and fresh acute myelogenous leukemia cells are all unreactive with EO-1. Immunoprecipitation of an extract from surface-131I-labeled platelets with EO-1 and sodium dodecyl sulfate polyacrylamide gel electrophoresis, under reducing or nonreducing conditions, yielded a specific band of molecular weight 23,000. Previously described monoclonal antibodies reacting with eosinophils also recognize neutrophils. EO-1 is a unique antibody with specificity restricted to eosinophils, basophils, and platelets and might therefore be a valuable reagent for the study of their function and differentiation.
Basic Amino Acid Transport in <i>Escherichia coli</i> : Properties of Canavanine-Resistant Mutants (1973)

A mutant of Escherichia coli strain CanR 22 has been isolated which is resistant to growth inhibition by canavanine, an analogue of arginine. The properties of this strain and of another canavanine-resistant mutant, JC182-5 (isolated by Celis et al. [5]), were studied. The mutation is pleiotropic in that it results in a reduction in the activity of two distinct permeases, the arginine-specific and lysine-arginine-ornithine transport systems. The lesion maps at min 56 of the E. coli linkage map, at or near the argP locus. Although strain CanR 22 excretes arginine, this excretion appears to result from reduced ability to concentrate arginine, rather than the loss of transport ability being the result of excretion. This conclusion is based on findings with a canavanine-resistant strain auxotrophic for arginine, which exhibits transport properties similar to those of the prototrophic strains. Additionally, growth in the presence of arginine or ornithine results in a repression of the activity of the two basic amino acid transport systems. Neither the arginine-specific nor the lysine-arginine-ornithine binding proteins of the mutant cells show significant alterations in terms of amount, physical properties, or kinetic parameters. These observations lead to the proposal of a model for the two basic amino acid transport systems in which two carrier proteins with different specificities interact with a common energy coupling mechanism. A lesion in the gene (or one of the genes) for this coupling mechanism can confer canavanine resistance.
Evaluation of hot carrier effects in TFT by emission microscopy (1992)

Hot carrier degradation of p-channel polycrystalline silicon thin film transistors was investigated by emission microscopy. An automatic measurement system was developed for the evaluation of hot carrier degradation. In the system, the measurement of electrical characteristics and the monitoring of photoemission are done simultaneously. This system was used to identify the dominant mechanism of hot carrier degradation in thin-film transistors and to evaluate the effect of plasma hydrogenation on hot carrier degradation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A new direction for computer architecture research (1998)

In the past few years, two important trends have evolved that could change the shape of computing: multimedia applications and portable electronics. Together, these trends will lead to a personal mobile-computing environment, a small device carried all the time that incorporates the functions of the pager, cellular phone, laptop computer, PDA, digital camera, and video game. The microprocessor needed for these devices is actually a merged general-purpose processor and digital-signal processor, with the power budget of the latter. Yet for almost two decades, architecture research has focused on desktop or server machines. We are designing processors of the future with a heavy bias toward the past. To design successful processor architectures for the future, we first need to explore future applications and match their requirements in a scalable, cost-effective way. The authors describe Vector IRAM, an initial approach in this direction, and challenge others in the very successful computer architecture community to investigate architectures with a heavy bias for the future.