gebhart/patrepeval huggingface dataset:
Particle- and Vapor-Phase Contributions to Metallic Impurities in Electronic-Grade Chlorine (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTParticle- and Vapor-Phase Contributions to Metallic Impurities in Electronic-Grade ChlorineTracey. Jacksier, Richard. Udischas, Hwa-Chi. Wang, and Ramon M. BarnesCite this: Anal. Chem. 1994, 66, 14, 2279–2284Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ac00086a013https://doi.org/10.1021/ac00086a013research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tumor necrosis factor acts synergistically with autocrine interferon-β and increases interferon-β mRNA levels in human fibroblasts (1989)

Medium of untreated human FS-4 foreskin fibroblasts contained a factor which, upon the addition of exogenous tumor necrosis factor (TNF), inhibited encephalomyocarditis virus replication when neither medium alone nor TNF alone were effective. This antiviral activity was abolished by a monoclonal antibody to human interferon (IFN)-beta, suggesting that the active component in the medium from untreated FS-4 cells was IFN-beta, present at subeffective concentrations. In addition, we show that untreated FS-4 cells contain IFN-beta mRNA, demonstrable by the highly sensitive polymerase chain reaction after reverse transcription. Treatment of FS-4 cells with TNF produced an approximately 16-fold increase in the steady-state level of IFN-beta mRNA. Our results support the conclusion that autocrine IFN-beta is secreted by untreated normal fibroblasts and that TNF can enhance the production of autocrine IFN-beta by increasing the level of IFN-beta mRNA. Our study also demonstrates that subeffective concentrations of autocrine IFN-beta, which escape detection in conventional assays, are sufficient to produce a strong synergistic action with TNF.
The need for biomarkers in amyotrophic lateral sclerosis drug development (2009)

Recent contributions to Neurology ® have highlighted the disappointing lack of demonstrated efficacy of novel therapeutic approaches to amyotrophic lateral sclerosis (ALS).1–3 Failure of translation, from promising preclinical studies to positive clinical trials, has raised concerns about the relevance of animal models and about clinical trial design. Development of novel therapeutics in ALS is also severely hampered by the lack of a biologic marker (biomarker) defined as “a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic response to a therapeutic intervention.”4 The importance of biomarkers in therapy development is underscored by the fact that for diseases in which good biomarkers exist, such as glycosylated hemoglobin for diabetes and serum lipid profiles for atherosclerotic coronary artery disease, there are multiple approved drugs, while for diseases in which there are no good biomarkers, such as Alzheimer disease, muscular dystrophy, and ALS, there are very few therapeutic options. Biomarkers have been proposed for ALS, although none are currently incorporated into clinical …
<i>WritLarge</i> (2017)

WritLarge is a freeform canvas for early-stage design on electronic whiteboards with pen+touch input. The system aims to support a higher-level flow of interaction by 'chunking' the traditionally disjoint steps of selection and action into unified selection-action phrases. This holistic goal led us to address two complementary aspects: SELECTION, for which we devise a new technique known as the Zoom-Catcher that integrates pinch-to-zoom and selection in a single gesture for fluidly selecting and acting on content; plus: ACTION, where we demonstrate how this addresses the combined issues of navigating, selecting, and manipulating content. In particular, the designer can transform select ink strokes in flexible and easily-reversible representations via semantic, structural, and temporal axes of movement that are defined as conceptual 'moves' relative to the specified content.
Properties of Water in Prestretched Recast Nafion (2008)

Uniaxially prestretched recast Nafion membranes exhibited an unusual combination of properties (a proton conductivity equal to that of commercial Nafion but with a lower methanol permeability) which make them ideal candidates for use in a direct liquid methanol fuel cell. To better understand the function and underlying morphology of the prestretched membranes, water uptake and mobility data were collected and analyzed for draw ratios ranging from 1 to 7. Macroscopic (gravimetric) water uptake and the water self-diffusion coefficient (measured by NMR) were found to be invariant with membrane elongation and essentially identical to those measured in a commercial Nafion 117 film (a similar behavior was observed for proton conductivity). The ratio of freezable/nonfreezable water in prestretched recast Nafion, the water electro-osmotic drag coefficient, and the spin−lattice relaxation time constant of deuterated water, however, decreased with increasing film elongation, up to a draw ratio of 4. The functional dependence of these properties on draw ratio was similar to that observed for methanol permeability. The combined water results indicated that there were a greater number of smaller ionic/hydrophilic domains in prestretched recast Nafion as compared to commercial Nafion. Transmission electron microscopy of membrane cross sections confirmed this conclusion.
Beyond the Memory Wall: A Case for Memory-Centric HPC System for Deep Learning (2018)

As the models and the datasets to train deep learning (DL) models scale, system architects are faced with new challenges, one of which is the memory capacity bottleneck, where the limited physical memory inside the accelerator device constrains the algorithm that can be studied. We propose a memory-centric deep learning system that can transparently expand the memory capacity available to the accelerators while also providing fast inter-device communication for parallel training. Our proposal aggregates a pool of memory modules locally within the device-side interconnect, which are decoupled from the host interface and function as a vehicle for transparent memory capacity expansion. Compared to conventional systems, our proposal achieves an average 2.8x speedup on eight DL applications and increases the system-wide memory capacity to tens of TBs.
High-average-power operation of a Q-switched diode-pumped holmium laser (1993)

We have investigated high-peak- and high-average-power operation of diode-pumped, thulium-sensitized, holmium 2.1-microm lasers. Free-running laser powers of 14 W at 29 Hz have been demonstrated with 2.6% electrical efficiency. Q-switched operation produced average powers in excess of 11 W in a burst of short pulses. Preliminary optical parametric oscillator frequency conversion of the holmium laser to 4 microm is also reported.
The significance of functional receptor heterogeneity in the biological responses of the rabbit neutrophil to stimulation by chemotactic formyl peptides (1991)

The characteristics of binding to the chemotactic receptors on rabbit peritoneal neutrophils were examined for seven formyl peptide analogues. These receptor-binding characteristics were compared with the abilities of the analogues to induce the biological responses of degranulation and chemotaxis. Five of the analogues showed distinct functional heterogeneity in their receptor-binding patterns, whereas the two most potent compounds displayed homogeneous binding patterns. The relative potencies of the formyl peptide analogues for stimulation of degranulation correlated well with their relative potencies for high-affinity, but not low-affinity, binding. The biphasic patterns for stimulation of chemotactic migration were similar for the less potent analogues, and their potencies paralleled those for both degranulation and receptor binding. In contrast, the most potent analogues induced a greater maximal extent of chemotactic migration than the other compounds, but displayed a lower than expected potency (i.e. they required higher than expected concentrations). These anomalies in the patterns of the chemotactic response cannot be reconciled with a simple receptor model comprising two independent classes of receptors. Instead, a model comprising interconvertible states of different affinities is proposed. The state of higher affinity appears to play a central role in initiation of both degranulation and chemotaxis. The more potent formyl peptide analogues are thought to stabilize an activated, higher-affinity, state of the receptor; this can explain their greater efficacy in stimulating chemotaxis. The proposed model may also be applicable to other receptors that are coupled by a guanine-nucleotide-binding regulatory protein to their associated effector.
Kinetics of iron oxidation upon polyphenol binding (2010)

Polyphenol prevention of iron-mediated DNA damage occurs primarily through iron binding. Once bound, iron in the Fe(2+)-polyphenol complex autooxidizes to Fe(3+) in the presence of O(2). To determine the correlation between the rate of Fe(2+)-polyphenol autooxidation and polyphenol antioxidant ability, kinetic studies at pH = 6.0 in the presence of oxygen were performed using UV-vis spectrophotometry. Initial rates of iron-polyphenol complex oxidation for epigallocatechin gallate (EGCG), methyl-3,4,5-trihydroxybenzoate (MEGA), gallic acid (GA), epicatechin (EC), and methyl-3,4-dihydroxybenzoate (MEPCA) were in the range of 0.14-6.7 min(-1). Polyphenols with gallol groups have faster rates of iron oxidation than their catechol analogs, suggesting that stronger iron binding results in faster iron oxidation. Concentrations of polyphenol, Fe(2+), and O(2) were varied to investigate the dependence of the Fe(2+)-polyphenol autooxidation on these reactants for MEGA and MEPCA. For these analogous gallate and catecholate complexes of Fe(2+), iron oxidation reactions were first order in Fe(2+), polyphenol, and O(2), but gallate complexes show saturation behavior at much lower Fe(2+) concentrations. Thus, gallol-containing polyphenols promote iron oxidation at a significantly faster rate than analogous catechol-containing compounds, and iron oxidation rate also correlates strongly with polyphenol inhibition of DNA damage for polyphenol compounds with a single iron-binding moiety.
Interface trap-enhanced gate-induced leakage current in MOSFET (1989)

Interface traps are shown to significantly affect the gate-induced drain-leakage current in a MOSFET or gated diode. The leakage current in a p/sup +/-gated diode can increase by two orders of magnitude when the interface trap density is increased from 10/sup 11/ to 10/sup 12/ cm/sup -2/-eV/sup -1/. The fact that thermal annealing at 300 degrees C can eliminate both the generated interface traps and the excessive leakage current supports the close correlation between the two. The p/sup +/-gated diode is found to be more susceptible to this interface-trap related leakage current than the n/sup +/-device, which can be explained qualitatively by an interface-trap-assisted tunneling model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Structure and activity of two photoreversible cinnamates bound to chymotrypsin (1990)

The serine protease gamma-chymotrypsin was covalently inhibited with two different photoreversible cinnamate compounds, and the structures of the resulting complexes were determined to 1.9-A resolution. The inhibitors show different kinetics of binding, inhibition, and nonphotochemical deacylation relative to each other in solution activity assays. The crystal structures of the enzyme-cinnamate complexes show that both compounds acylate serine 195 and that the two molecules are bound in similar nonproductive conformations which have drastic effects on their ability to turn over. Substitution of a diethylamino group on the para position of the cinnamate ring causes a 1000-fold increase in the thermal stability of the inhibitor toward hydrolysis and deacylation.
U.S. support for nuclear energy safety and cooperation in the pacific basin (1994)

Nuclear power plays an important role in the energy and economic development of Pacific Rim countries. Concurrent with the construction of commercial nuclear power plants, there is a vital need to develop strong nuclear safety infrastructures in all countries choosing to use nuclear energy for electricity production. One of the most important elements in developing a viable nuclear program is a nuclear safety culture, rigorously applied to nuclear plant siting, design, construction, operation and management. International cooperation provides an important mechanism for raising the level of nuclear safety worldwide. The NRC has recently increased its international efforts in the nuclear safety area, with particular emphasis on Central and Eastern Europe and the New Independent States of the former Soviet Union. The NRC will continue, and is prepared to expand, its cooperation with counterpart organizations in Pacific Rim countries to help establish and nurture a safety culture that will respond to the dynamic process of nuclear energy development over the next few years.
Oncogenic capacity of the E2F1 gene. (1994)

Previous experiments have identified the E2F transcription factor as a potential downstream target for the action of cellular regulatory activities, such as the Rb tumor suppressor protein, that control cell growth and that, when altered, contribute to the development of human tumors. In light of these findings, we have assayed the ability of the E2F1 and DP1 genes, which encode heterodimeric partners that together create E2F activity, to act in an oncogenic fashion. We find that E2F1, particularly in combination with the DP1 product, cooperates with an activated ras oncogene to induce the formation of morphologically transformed foci in primary rat embryo fibroblast cultures. In addition, an E2F1 chimeric protein, in which sequences involved in Rb binding have been replaced with the herpesvirus VP16 activation domain, exhibits increased transformation activity. Cells transfected with E2F1 and DP1 or the E2F1-VP16 chimera form colonies in soft agar and induce tumor formation in nude mice. We conclude that deregulated E2F1 expression and function can have oncogenic consequences.
Hybrid Passive/Active Impact Detection & Localization for Aerospace Structures (2013)

This paper presents finding from a recent set of formal performance assessments studies, quantifying the ability of a hybrid passive/active SHM system to detect impact damage. The SHM system itself is an integrated device including an array of PZT sensors with a central PZT actuator, analog-to-digital converter, memory and FPGA. In passive mode, the system uses the central PZT element for triggering and the array of PZT sensors to detect and localize acoustic emissions (AE) propagating from the impact source. Subsequently, an active mode is triggered to capture the guided wave (GW) response of the resulting impact damage to a narrowband excitation measured from the same PZT array. In both cases, a phase-coherent beamforming approach is used to process the data. A single node was mounted to a 0.6 x 0.6 m square 2 mm thick aluminum plate with a row of 20 fasteneres, which was then subjected to 36 impact events of ~20 J. In addition, 6 tests were conducted to further predict the presence of a loosened fastener on the assembly. Results of the study indicated that the AE mode was extremely sensitive to small impacts even at a great distance with localization errors on the order of 25 mm. Similarly, while the GW mode errors were closer to 50 mm for localization for ~0.5 mm dents, the error for detection of loosened fasteners was less than 5 mm.
Effects of Long-Term Nitroglycerin Treatment on Endothelial Nitric Oxide Synthase (NOS III) Gene Expression, NOS III–Mediated Superoxide Production, and Vascular NO Bioavailability (2000)

Long-term nitroglycerin (NTG) treatment has been shown to be associated with cross-tolerance to endothelium-dependent vasodilators. It may involve increased production of reactive oxygen species (such as superoxide, O(2)(.-)) that rapidly inactivate the nitric oxide (NO) released from the endothelial cells. It remains to be elucidated, however, whether long-term treatment with NTG alters the activity and expression of the endothelial NO synthase (NOS III) and whether this enzyme can contribute to O(2)(.-) formation. We studied the influence of long-term NTG treatment on the expression of NOS III as assessed by RNase protection assay and Western blot. Tolerance was measured ex vivo in organ chamber experiments with rat aortic rings. O(2)(.-) and NO formation were quantified using lucigenin- and Cypridina luciferin analog-enhanced chemiluminescence as well as electron spin resonance (ESR) spectroscopy. Treatment of Wistar rats with NTG (Alzet osmotic minipumps, NTG concentration 10 microg x kg(-1) x min(-1)) for 3 days caused marked tolerance, cross-tolerance to the endothelium-dependent vasodilator acetylcholine, and a significant increase in O(2)(.-)-induced chemiluminescence. Tolerance was associated with a significant increase in NOS III mRNA to 236+/-28% and NOS III protein to 239+/-17%. In control vessels, the NOS inhibitor N(G)-nitro-L-arginine (L-NNA) increased the O(2)(.-)-mediated chemiluminescence, indicating that basal production of endothelium-derived NO depresses the baseline chemiluminescence signal. In the setting of tolerance, however, L-NNA decreased steady-state O(2)(.-) levels, indicating the involvement of NOS III in O(2)(.-) formation. Likewise, A23187-induced, NOS III-mediated O(2)(.-) production was more pronounced in tolerant than in control vessels. Vascular NO bioavailability as assessed with ESR spectroscopy using iron-thiocarbamate as a trap for NO was significantly reduced in tolerant vessels. Pretreatment of tolerant tissue in vitro with the protein kinase C (PKC) inhibitors reduced basal and stimulated NOS III-mediated O(2)(.-) production and partially reversed vascular tolerance. These findings suggest that NTG treatment increases the expression of a dysfunctional NOS III gene, leading to increased formation of O(2)(.-) and decreased vascular NO bioavailability. Normalization of NOS III-mediated O(2)(. -) production and improvement of tolerance with PKC inhibition suggests an important role for PKC isoforms in mediating vascular dysfunction caused by long-term NTG treatment.
Rapid determination of glomerular filtration rate by single-bolus inulin: a comparison of estimation analyses (1998)

Rapid measurement of glomerular filtration rate (GFR) by an inulin single-bolus technique would be useful, but its accuracy has been questioned. We hypothesized that reported inaccuracies reflect the use of inappropriate mathematical models. GFR was measured in 14 intact and 5 unilaterally nephrectomized conscious male Sprague-Dawley rats (mean weight 368 +/- 12 g) by both single-bolus (25 mg/kg) and constant-infusion techniques (0.693 mg . kg-1 . min-1). The temporal decline in plasma inulin concentration was analyzed through biexponential curve fitting, which accounted for renal inulin loss before complete vascular and interstitial mixing. We compared our mathematical model based on empirical rationale with those of other investigators whose studies suggest inaccuracy of single-bolus methods. Our mathematical model yielded GFR values by single bolus that agreed with those obtained by constant infusion [slope = 0.94 +/- 0.16 (SE); y intercept = 0.23 +/- 0.64; r = 0.82]. In comparison to the data obtained by constant inulin infusion, this method yielded a very small bias of -0.0041 +/- 0.19 ml/min. Two previously reported models yielded unsatisfactory values (slope = 1. 46 +/- 0.34, y intercept = 0.47 +/- 1.5, r = 0.72; and slope = 0.17 +/- 1.26, y intercept = 17.15 +/- 5.14, r = 0.03). The biases obtained by using these methods were -2.21 +/- 0.42 and -13.90 +/- 1. 44 ml/min, respectively. The data indicate that when appropriate mathematical models are used, inulin clearance after single-bolus delivery can be used to measure GFR equivalent to that obtained by constant infusion of inulin. Attempts to use methods of analysis for simplicity or expediency can result in unacceptable measurements relative to the clinical range of values seen.
Very high speed serial and serial-parallel computers HITAC 5020 and 5020E (1964)

HITAC 5020 family consists of general purpose computing systems designed to solve a wide variety of problems for both scientific and business data processing.
Measurements for enhanced bandwidth performance over 62.5-μm multimode fiber in short-wavelength local area networks (2003)

The Telecommunications Industry Association (TIA) FO-2.2.1 Working Group on the modal dependence of bandwidth has conducted industrywide interlaboratory comparisons on measurements aimed at improving the bandwidth performance of short-wavelength, laser-based, multimode-fiber local area networks (LANs). Measurements of both transceiver encircled flux and fiber restricted-mode-launch bandwidth can together successfully predict an enhanced system performance, provided that the proper limiting criteria are selected. System performance is determined by a measurement of effective bandwidth and/or intersymbol interference. Recommendations for source and fiber selection criteria come from a risk analysis based on an extensive multilaboratory comparison involving 95 fibers and 69 laser transceivers. For this paper, enhanced system performance is defined as a performance that allows operation at a data rate of at least one gigabit per second over a 500-m length of 62.5/125-μm graded-index glass fiber.
Quantitative RNFL attenuation coefficient measurements by RPE-normalized OCT data (2012)

We demonstrate significantly different scattering coefficients of the retinal nerve fiber layer (RNFL) between normal and glaucoma subjects. In clinical care, SD-OCT is routinely used to assess the RNFL thickness for glaucoma management. In this way, the full OCT data set is conveniently reduced to an easy to interpret output, matching results from older (non- OCT) instruments. However, OCT provides more data, such as the signal strength itself, which is due to backscattering in the retinal layers. For quantitative analysis, this signal should be normalized to adjust for local differences in the intensity of the beam that reaches the retina. In this paper, we introduce a model that relates the OCT signal to the attenuation coefficient of the tissue. The average RNFL signal (within an A-line) was then normalized based on the observed RPE signal, resulting in normalized RNFL attenuation coefficient maps. These maps showed local defects matching those found in thickness data. The average (normalized) RNFL attenuation coefficient of a fixed band around the optic nerve head was significantly lower in glaucomatous eyes than in normal eyes (3.0mm<sup>-1</sup> vs. 4.9mm<sup>-1</sup>, P<0.01, Mann-Whitney test).