gebhart/patrepeval huggingface dataset:
[Indications and current developments in liver transplantation]. (1989)

Today, liver transplantation has become a routine treatment in many centres and will be increasingly applied in the future. Principal indications for liver transplantation are endstage chronic liver diseases, namely cirrhoses of various origin, fulminant hepatic failure, metabolic liver disease, and rarely non-resectable malignant tumors of the liver. Clinical and biochemical parameters indicative of the indication for liver transplantation can be stated with greater confidence. Advances in organ preservation with a new cold storage solution (University of Wisconsin solution) and further refinements in surgical technique and immunosuppression with application of multimodal protocols have led to a one-year-survival rate of 70%-80% in experienced centers. Since October 1988, 32 patients underwent liver transplantation in Berlin, currently, 31 patients are alive, while one patient died due to systemic fungal infection.
Structural proteins of hog cholera virus expressed by vaccinia virus: further characterization and induction of protective immunity (1991)

A cDNA fragment covering the genomic region that encodes the structural proteins of hog cholera virus (HCV) was inserted into the tk gene of vaccinia virus. Expression studies with vaccinia virus/HCV recombinants led to identification of HCV-specific proteins. The putative HCV core protein p23 was demonstrated for the first time by using an antiserum against a bacterial fusion protein. The glycoproteins expressed by vaccinia virus/HCV recombinant migrated on sodium dodecyl sulfate-gels identically to glycoproteins precipitated from HCV-infected cells. A disulfide-linked heterodimer between gp55 and gp33 previously detected in HCV-infected cells was also demonstrated after infection with the recombinant virus. The vaccinia virus system allowed us to identify, in addition to the heterodimer, a disulfide-linked homodimer of HCV gp55. The vaccinia virus/HCV recombinant that expressed all four structural proteins induced virus-neutralizing antibodies in mice and swine. After immunization of pigs with this recombinant virus, full protection against a lethal challenge with HCV was achieved. A construct that lacked most of the HCV gp55 gene failed to induce neutralizing antibodies but induced protective immunity.
High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH (2005)

Chromosomal regions harboring tumor suppressors and oncogenes are often deleted or amplified. Array comparative genomic hybridization detects segmental DNA copy number alterations in tumor DNA relative to a normal control. The recent development of a bacterial artificial chromosome array, which spans the human genome in a tiling path manner with >32,000 clones, has facilitated whole genome profiling at an unprecedented resolution. Using this technology, we comprehensively describe and compare the genomes of 28 commonly used non-small cell lung carcinoma (NSCLC) cell models, derived from 18 adenocarcinomas (AC), 9 squamous cell carcinomas and 1 large cell carcinoma. Analysis at such resolution not only provided a detailed genomic alteration template for each of these model cell lines, but revealed novel regions of frequent duplication and deletion. Significantly, a detailed analysis of chromosome 7 identified 6 distinct regions of alterations across this chromosome, implicating the presence of multiple novel oncogene loci on this chromosome. As well, a comparison between the squamous and AC cells revealed alterations common to both subtypes, such as the loss of 3p and gain of 5p, in addition to multiple hotspots more frequently associated with only 1 subtype. Interestingly, chromosome 3q, which is known to be amplified in both subtypes, showed 2 distinct regions of alteration, 1 frequently altered in squamous and 1 more frequently altered in AC. In summary, our data demonstrate the unique information generated by high resolution analysis of NSCLC genomes and uncover the presence of genetic alterations prevalent in the different NSCLC subtypes.
Injection- Seeded Optoplasmonic Amplifier in the Visible (2014)

A hybrid optoplasmonic amplifier, injection-seeded by an internally-generated Raman signal and operating in the visible (563-675 nm), is proposed and evidence for amplification is presented. Comprising a gain medium tethered to a whispering gallery mode (WGM) resonator with a protein, and a plasmonic surface, the optical system described here selectively amplifies a single (or a few) Raman line(s) produced within the WGM resonator and is well-suited for routing narrowband optical power on-a-chip. Over the past five decades, optical oscillators and amplifiers have typically been based on the buildup of the field from the spontaneous emission background. Doing so limits the temporal coherence of the output, lengthens the time required for the optical field intensity to reach saturation, and often is responsible for complex, multiline spectra. In addition to the spectral control afforded by injection-locking, the effective Q of the amplifier can be specified by the bandwidth of the injected Raman signal. This characteristic contrasts with previous WGM-based lasers and amplifiers for which the Q is determined solely by the WGM resonator.
Genetic mapping of autosomal dominant Charcot-Marie-Tooth disease in a large French-Acadian kindred: identification of new linked markers on chromosome 17. (1990)

We have performed linkage analysis in a large French-Acadian kindred segregating one form of autosomal dominant Charcot-Marie-Tooth disease (CMTD) (type IA) using 17 polymorphic DNA markers spanning human chromosome 17 and demonstrate linkage to several markers in the pericentromeric region, including DNA probes pA10-41, EW301, S12-30, pTH17.19, c11-2B, and p11-2c11.5. Linkage of markers pA10-41 and EW301 to CMTD type IA has been reported elsewhere. Four new markers, 1516, 1517, 1541, and LL101, which map to chromosome 17 have been identified. The marker 1516 appears to be closely linked to the CMTD locus on chromosome 17 as demonstrated by a maximum lod score of 3.42 at theta (recombination fraction) = 0. This marker has been mapped to 17p11.2 using a somatic cell hybrid constructed from a patient with Smith-Magenis syndrome [46,XY, del(17)(p11.2p11.2)]. A lod score of 6.16 has been obtained by multipoint linkage analysis with 1516 and two markers from 17q11.2, pTH17.19, and c11-2B. The markers 1517 and 1541 have been mapped to 17p12-17q11.2 and demonstrate maximum lod scores of 2.35 and 0.63 at recombination values of .1 and .2, respectively. The marker LL101 has been mapped to 17p13.105-17p13.100 and demonstrates a maximum lod score of 1.56 at a recombination value of .1. Our study confirms the localization of CMTD type IA to the pericentromeric region of chromosome 17.
Itakura-Saito nonnegative matrix factorization with group sparsity (2011)

We propose an unsupervised inference procedure for audio source separation. Components in nonnegative matrix factorization (NMF) are grouped automatically in audio sources via a penalized maximum likelihood approach. The penalty term we introduce favors sparsity at the group level, and is motivated by the assumption that the local amplitude of the sources are independent. Our algorithm extends multiplicative updates for NMF ; moreover we propose a test statistic to tune hyperparameters in our model, and illustrate its adequacy on synthetic data. Results on real audio tracks show that our sparsity prior allows to identify audio sources without knowledge on their spectral properties.
THE REACTION OF NINHYDRIN WITH POLYMETHYLBENZENES IN THE PRESENCE OF ACID CATALYST: FORMATION OF 2-ARYL-1,3-INDANEDIONE AND INDENOINDANONE DERIVATIVES (1999)

Hyun Nam Song, Hong Jung Lee, Tae Yi Kim, and Jae Nyoung Kim*Department of Chemistry, Chonnam National University, Kwangju 500-757, KoreaReceived June 24, 1999Recently, Friedel-Crafts type reactions of some cyclicketone systems such as ninhydrin, alloxan, isatin, and para-banic acid have been examined extensively.
Motion planning on steep terrain for the tethered axel rover (2011)

This paper considers the motion planning problem that arises when a tethered robot descends and ascends steep obstacle-strewn terrain. This work is motivated by the Axel tethered robotic rover designed to provide access to extreme extra-planetary terrains. Motion planning for this type of rover is very different from traditional planning problems because the tether geometry under high loading must be considered during the planning process. Furthermore, only round-trip paths that avoid tether entanglement are viable solutions to the problem. We present an algorithm for tethered robot motion planning on steep terrain that reduces the likelihood that the tether will become entangled during descent and ascent of steep slopes. The algorithm builds upon the notion of the shortest homotopic tether path and its associated sleeve. We provide a simple example for purposes of illustration.
Computer-assisted Surgical Planning for Cerebrovascular Neurosurgery (1997)

Computer-assisted surgical planning is useful for patients with cerebrovascular disease at various stages of treatment. Lesion identification, therapeutic and surgical option planning, and intraoperative localization are all enhanced with these techniques.
Effects of medroxyprogesterone acetate or gonadotrophin-releasing hormone agonist on suppression of spermatogenesis in the dog (Canis familiaris). (1993)

Medroxyprogesterone acetate (MPA) was administered as a depot injection to two adult male dogs. One was injected with 75 mg as a depot injection once a month for 2 months and the other with 50 mg at 2-weekly intervals for 1 month, followed by 100 mg at 2-weekly intervals for a further 2 months. Two other male beagles were given gonadotrophin-releasing hormone (GnRH) agonists (nafarelin derivative no. 49947 and nafarelin acetate) at a dose of 50 micrograms day-1 for either 22 or 23 days. The profiles of luteinizing hormone (LH) and testosterone were monitored before and during the treatment periods, and changes in the dogs' testes, epididymides and prostate glands were determined post mortem. In the MPA-treated animals, LH was suppressed for only very brief periods. In contrast, in the dogs treated with GnRH agonist, LH and testosterone concentrations were suppressed for most of the treatment period. In the MPA-treated animals, histological changes were seen mainly in the head of the epididymis, and in the acrosome region of the spermatozoa still present in this region of the male reproductive tract. The acrosome, instead of being closely applied to the sperm head, was in contact only in the most anterior areas, with the remainder forming a fan-like projection, indicating increasing detachment from the sperm head. In the dogs treated with GnRH agonist there was clear evidence of cessation of normal spermatogenesis in most of the seminiferous tubules. Changes in the histology of the head of the epididymis were similar to (but more profound than) those found in the dogs treated with MPA. Seminal changes were demonstrated in ejaculates collected during the latter stages of the treatment period.
Synergism in the Inhibition of <i>Bacillus subtilis</i> by Combinations of Lipophilic Weak Acids and Fatty Alcohols (1981)

Combinations of two lipophilic weak acids and alcohols acted synergistically to inhibit growth of Bacillus subtilis. Alcohols contributed to both reversible and irreversible inhibitions by acids.
A New Toxic Substance, Teleocidin, Produced by Streptomyces (1962)

The production and isolation of a new toxic substance, Teleocidin, and its biological properties were previously reported. Thereafter it has been found that an other strain ofStreptomycesproduced such specific toxic substance as Teleocidin in its cultured mycellium. Comparative tests of these two purified crystalline powders showed the new toxic substance resembles Teleocidin closely though differs in certain chemical properties. Therefore, the original Teleocidin is designated Teleocidin A, whereas that produced by a new strain of Streptomycesis named Teleocidin B, which had been tentatively called as the SK-toxic substance.From the results of the chemical studies of Teleocidin B and its hydrogenated derivative, which was easily obtained as a crystalline form by the catalytic hydrogenation of Teleocidin B with Adam's catalyst, molecular formula, C28H39-41N3O2 was postulated for Teleocidin B.It was also recognized that an alcoholic hydroxyl, a lactam ring and a heterocyclic ring like indole or pyrrole structure existed as the functional groups of Teleocidin B.
Deoxyribonucleic Acid Synthesis in Bacteriophage SP01-infected Bacillus subtilis (1973)

Abstract A new DNA polymerase has been purified 1000-fold from Bacillus subtilis infected with bacteriophage SP01. It consists of a single polypeptide chain of approximately 122,000 molecular weight. The enzyme requires deoxyribonucleoside 5'-triphosphates, Mg2+, β-mercaptoethanol, and single stranded DNA templates for activity. Bihelical DNA which has been partially denatured serves as the preferred template in in vitro reactions. Although 5-hydroxymethyluracil replaces thymine in SP01 DNA, deoxynucleotide analogues of 5-hydroxymethyldeoxyuridine 5'-triphosphate can serve as efficient substrates for the phage polymerase. The purified enzyme is free of endonuclease activity.
Synthesis and Antitumor Activity of Glycyrrhetic Acid Derivatives (2001)

Six new glycyrrhetic acid derivatives were synthesized from the reaction of di(2 chloroethyl)aminophosohonyl dichloride(4) with methyl glycyrrhetinate(1), methyl 11 deoxy glycyrrhetinate(2), and 3 β 30 dioxy 12 ene oleanane(3), respectively. Their structures were confirmed by MS, 1H NMR and elemental analysis. The preliminary antitumor activity tests against EAC cells both in vitro and in rovo showed that the new compounds especially Ⅰ a and Ⅰ b exhibited a good antifumor activity in comparison with the nitrogen mustard.
Modeling extracellular electrical stimulation: II. Computational validation and numerical results (2012)

The validity of approximate equations describing the membrane potential under extracellular electrical stimulation (Meffin et al 2012 J. Neural Eng. 9 065005) is investigated through finite element analysis in this paper. To this end, the finite element method is used to simulate a cylindrical neurite under extracellular stimulation. Laplace's equations with appropriate boundary conditions are solved numerically in three dimensions and the results are compared to the approximate analytic solutions. Simulation results are in agreement with the approximate analytic expressions for longitudinal and transverse modes of stimulation. The range of validity of the equations describing the membrane potential for different values of stimulation and neurite parameters are presented as well. The results indicate that the analytic approach can be used to model extracellular electrical stimulation for realistic physiological parameters with a high level of accuracy.
Time-resolved 3d capture of non-stationary gas flows (2008)

Fluid simulation is one of the most active research areas in computer graphics. However, it remains difficult to obtain measurements of real fluid flows for validation of the simulated data.
Faraday Rotation in Praseodymium, Terbium, and Dysprosium Alumina Silicate Glasses (1964)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Charles C. Robinson and Robert E. Graf, "Faraday Rotation in Praseodymium, Terbium, and Dysprosium Alumina Silicate Glasses," Appl. Opt. 3, 1190-1191 (1964) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
HL-60 cell line was derived from a patient with FAB-M2 and not FAB-M3 (1988)

The leukemia from which the human cell line HL-60 was derived was classified in 1976 as acute progranulocytic leukemia (APL), although it was recognized to show a number of atypical features. In the ensuing 10 years, the concept of APL and its integral association with t(15;17) has evolved, and the concept of APL as a morphologically recognizable entity has become embodied in the term French-American-British classification M3 (FAB-M3). It is now recognized that not every case of leukemia with a high proportion of progranulocytes can be classified as FAB-M3. We reviewed the light and ultrastructural morphology of the original diagnostic material from this case, and we report that the leukemia from which HL-60 was derived does not conform to the currently recognized entity of FAB-M3 and is more appropriately classified as an acute myeloblastic leukemia with maturation, FAB-M2.
Depression of vaccinal immunity to marek's disease by infection with chicken Anaemia agent (1988)

Chicken anaemia agent (CAA) depressed protective vaccinal immunity against Marek's disease (MD) when vaccinated chicks were inoculated with CAA at 1 to 14 days of age. In chicks inoculated with CAA alone, a typical CAA infection as manifested by early mortality, decrease in haematocrit value, severe lymphoid depletion in the lymphoid organs, and aplasia of the bone marrow occurred only when one-day-old chicks were inoculated. When both turkey herpesvirus (HVT) and CAA were inoculated, a typical CAA infection occurred even if chicks were inoculated with CAA at 8 days of age. The response of splenic lymphocytes to mitogen stimulation was more severely depressed in chicks dually inoculated with HVT and CAA than in chicks inoculated with CAA alone. These results suggest that the depressive effect of CAA infection on HVT vaccinal immunity may be due to a severe impairment to T cell-mediated immunity resulting from enhanced pathogenicity of CAA in vaccinated chicks.
Engineering plastics from lignin. VI. Structure–property relationships of PEG-containing polyurethane networks (1985)

Hydroxypropyl lignin-based thermosetting polyurethanes were synthesized with excess hexamethylene diisocyanate (HDI) and tolylene diisocyanate (TDI) by solution casting. Four polyethylene glycols (PEG) of molecular weight 400, 600, 1000, and 4000 were mixed with lignin polyol to incorporate different proportions of soft segment into the network prior to crosslinking. Neither thermal nor mechanical and limited small angle x-ray scattering (SAXS) analysis provided distinct evidence for phase separation and microstructure formation. The study examines the effect of the soft segment in relation to chain length and weight contribution on the thermal and mechanical properties of the final networks. A significant sensitivity of glass transition temperature (Tg), of swelling in DMF, and of the mechanical properties to soft segment content was observed. Some of this sensitivity must, however, be attributed to differences in crosslink density since the polyol to diisocyanate weight ratio was kept constant throughout the synthesis series. The magnitude of the change of the different properties was found to be influenced by both glycol content and glycol molecular weight. The Tg of the network decreased from 105°C to as low as 38°C (HDI), and from 158°C to 70°C (TDI), with incorporation of up to 17.8% glycol, and it was greater with lower molecular weight glycols than with higher ones at any weight fraction. Swelling in DMF increased as expected with soft segment content. Mechanical properties were affected most if HDI and lower molecular weight glycols were used. The uniformity in structure, reduction in brittleness, and considerable improvement in mechanical properties with inclusion of minor PEG contents indicates that lignin-based network polyurethanes can be synthesized with controllable performance characteristics.
Standards for energy management system application program interfaces (2002)

This paper introduces draft IEC standard 61970. This standard develops the guidelines and information model produced by the EPRI Control Centre Application Program Interface (CCAPI) project. The first part of the standard is a reference model describing the expected architecture and listing the major categories of applications. The major work completed is a common information model that is an object-oriented representation of a power system as viewed by energy management systems. One part describes physical based entities such as substation and conducting equipment. This model of network equipment and connectivity can also be used within distribution management systems. Other parts describe abstract entities related to the financial and scheduling data required for deregulated operation of power systems. Work is continuing to define the component interface standards for each of the application categories. This work is using a software design process that analyses the information exchanges described in use cases.
H5N1 Influenza Vaccine Formulated with AS03A Induces Strong Cross-Reactive and Polyfunctional CD4 T-Cell Responses (2010)

Formulation of the H5N1 vaccine with AS03(A) enhances antibody persistence and induces stronger T- and B-cell responses. The cross-clade T-cell immunity indicates that the adjuvanted vaccine primes individuals to respond to either infection and/or subsequent vaccination with strains drifted from the primary vaccine strain.
Morphological transformation and growing character of Helicobacter pylori--Role of an improved broth medium (2000)

Objective Observing morphological changes and growing characters of Helicobacter pylori(Hp); Studying the role of an improved broth medium in Hp growth. Methods Frozen and plate cultured Hp strains were exposed to air, and then were observed for morphological changes under light microscope and growing characters at different exposure time. Culturing the Hp strains which had already been exposed to air for a different time with the improved broth medium and Columbia plate respectively. Result When exposed to air, frozen strains were observed losing their growing capacity on Columbia plate in 0.7 hour, beginning to change into coccal shape in 0.8 hour, and completely transforming into coccal form in 66.5 hours. As to the Hp strains cultured on Columbia plate, they were observed beginning to change into coccal shape in 1.9 hour, losing growing capacity on Columbia plate in 8.2 hours, completely transforming into coccal form in 33.2 hours, and wholely losing urease activity in 84.3 hours. Cultured with the improved broth medium, the frozen and plate cultured strains could be revived after exposed to air for 22.4 and 56.4 hours respectively. A portion of coccal form bacteria could be reverted to spiral or “S” shape after cultured with the improved broth medium. Conclusion The improved broth medium could revive Helicobacter pylori from its transformed coccal form.
Secure commerce on the Internet (1996)

Introduction: Background and History of the Internet. Internet Commerce: TCP/IP and the Internet. World Wide Web. Commerce on the Web. Internet Security: Security Breaches. Security Issues and Concepts. Internet Security. Firewalls. Secure Commerce: Model of Secure Commerce. User Certification. Web Security. Online Banking. Secure Payments. Secure Commerce. Glossary of Internet Terms.
The Evaluation of East Asian Regionalism from APEC to RCEP (2013)

Building a large trading bloc tends to produce substantial economic gains, while minimizing economic losses from overlapping FTAs. East Asia has tried to generate the impetus for promoting region-wide trading blocs, but most of those blocs have been overlapped and multilayered. This paper reviews the evolution of East Asian regionalism from the APEC FTA under the 1994 Bogor Goal to recent RCEP promoted in 2013. This paper underlines that the continued expansion of multilayered trading blocs in East Asia works as a serious obstacle to regional economic integration, rather than exploring the realization of a region-wide trading bloc.