gebhart/patrepeval huggingface dataset:
Voltage harmonics generated by voltage-fed inverters using PWM natural sampling (1988)

The harmonics generated by natural sampled pulse width modulation are investigated experimentally and by theoretical models for the outputs obtained with triangular and sawtooth carrier signals. These equations are valid for synchronous and asynchronous operation. It is shown that triangular carriers generate less harmonics than sawtooth carriers, and that in synchronous operation with single-phase modulation, the carrier-to-output frequency ratio may be any integer value.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A facile fabrication of large-scale reduced graphene oxide–silver nanoparticle hybrid film as a highly active surface-enhanced Raman scattering substrate (2015)

Larger-scale reduced graphene oxide–silver nanoparticle hybrid film can serve as a novel SERS-active substrate for detecting R6G and MA.
Yng1p Modulates the Activity of Sas3p as a Component of the Yeast NuA3 Histone Acetyltransferase Complex (2002)

The mammalian ING1 gene encodes a tumor suppressor required for the function of p53. In this study we report a novel function for YNG1, a yeast homolog of ING1. Yng1p is a stable component of the NuA3 histone acetyltransferase complex, which contains Sas3p, the yeast homolog of the mammalian MOZ proto-oncogene product, as its catalytic subunit. Yng1p is required for NuA3 function in vivo but surprisingly is not required for the integrity of the complex. Instead, we find that Yng1p mediates the interaction of Sas3p with nucleosomes and is thus required for the ability of NuA3 to modify histone tails. These data, and the observations that other ING1 homologs are found in additional yeast complexes that posttranslationally modify histones, suggest that members of the ING1 class of proteins may have broad roles in enhancing or modifying the activities of chromatin-modifying complexes, thereby regulating their activities in transcription control.
The effect of metoclopramide on the absorption of effervescent aspirin in migraine. (1975)

1 The absorption of effervescent aspirin was studied in two groups of patients during attacks of migraine. The first group received effervescent aspirin alone whilst the second group received intramuscular metoclopramide before effervescent aspirin. 2 After effervescent aspirin alone there was significant impairment in the rate of aspirin absorption during migraine attacks compared with the rate of aspirin absorption in normal volunteers and in the same patients when headache-free. 3 When metoclopramide was given before effervescent aspirin the rate of aspirin absorption during migraine attacks was not significantly different from that obtained in normal volunteers given effervescent aspirin alone or from that obtained in the patients themselves when given both metoclopramide and effervescent aspirin when headache-free. 4 It is concluded that the impairment of absorption of effervescent aspirin during migraine attacks is related to impaired gastro-intestinal motility with delayed gastric emptying and that this impaired motility can be overcome by parenteral metoclopramide.
Recognition and Selective Transport of Nucleic Acid Components through Molecularly Imprinted Polymeric Membranes (2001)

To induce “molecular memory” in a membrane substrate at the same time that the membrane was prepared from its polymer solution, an alternative molecular imprinting technique was applied. Upon membrane formation, a “molecular memory” of the imprint molecule is retained by the formed membrane that recognizes or favors interaction with print molecule analogues. In the present study, polystyrene resin bearing a tetrapeptide derivative, a derivative of natural polymer, and an entirely non-chiral synthetic polymer were adopted as candidate materials to form molecular recognition sites. 9-Ethyladenine was adopted as a print molecule. These molecularly imprinted polymeric membranes recognized and adsorbed adenosine (As), which is an analogue of the print molecule, in preference to guanosine (Gs) from As/Gs mixtures. However Gs was permeated in preference to As contrary to adsorption selectivity, possibly because of the relatively high affinity between As and the membrane.
Map-Based Cloning of a Gene Controlling Omega-3 Fatty Acid Desaturation in <i>Arabidopsis</i> (1992)

A gene from the flowering plant Arabidopsis thaliana that encodes an omega-3 desaturase was cloned on the basis of the genetic map position of a mutation affecting membrane and storage lipid fatty acid composition. Yeast artificial chromosomes covering the genetic locus were identified and used to probe a seed complementary DNA library. A complementary DNA clone for the desaturase was identified and introduced into roots of both wild-type and mutant plants by Ti plasmid-mediated transformation. Transgenic tissues of both mutant and wild-type plants had significantly increased amounts of the fatty acid produced by this desaturase.
A Human Monoclonal Antibody against Hepatitis B Surface Antigen with Potent Neutralizing Activity (2015)

We describe the production and characterization of human monoclonal antibodies (mAb) specific for the major hepatitis B virus (HBV) S protein. The mAbs, two IgG1κ and one IgG1λ, were secreted by B-cell clones obtained from peripheral blood mononuclear cells (PBMC) of one person convalescent from acute hepatitis B and one vaccinated individual. The former recognized a denaturation-insensitive epitope within the p24 protein whereas the latter recognized a denaturation-sensitive, conformational epitope located within the HBsAg common "a" determinant. This mAb, denominated ADRI-2F3, displayed a very high protective titer of over 43,000 IU/mg mAb and showed an extremely potent neutralizing activity in the in vitro model of HBV infection using primary hepatocytes from Tupaia belangeri as target. Recombinant variable heavy and light domain sequences derived from mAb ADRI-2F3 were cloned into eukaryotic expression vectors and showed identical fine specificity and 1 log10 higher titer than the original IgG1λ. It is envisaged that such mAb will be able to efficiently prevent HBV reinfection after liver transplantation for end-stage chronic HBV infection or infection after needle-stick exposure, providing an unlimited source of valuable protective anti-HBs antibody.
Efficient flip-chip InGaN micro-pixellated light-emitting diode arrays: promising candidates for micro-displays and colour conversion (2008)

Flip-chip InGaN micro-pixellated LED arrays with high pixel density and improved device performance are presented. The devices, with 64 × 64 elements, each of which have a 20 µm emission aperture on a 50 µm pitch, are fabricated with a matrix-addressable scheme at blue (470 nm) and UV (370 nm) wavelengths, respectively. These devices are then flip-chip bonded onto silicon mounts. Good emission uniformity across the LED array is demonstrated, which can be attributed to the introduced n-metal tracks adjacent to each n-GaN mesa and the p-contact lines running across parallel columns. More importantly, with a flip-chip configuration, the optical power output and the current-handling capability of these new devices are substantially enhanced, due to the improved heat dissipation capability and the increased light extraction efficiency. For instance, each pixel in the flip-chip blue (respectively UV) LED arrays can provide a maximum power density 43 W cm−2 (respectively 6.5 W cm−2) at an extremely high current density up to 4000 A cm−2 before breakdown. These flip-chip devices are then combined with a computer-programmable driver circuit interface to produce high-quality micro-scale displays. Other promising applications of these LEDs, such as colour conversion with quantum dots, are also demonstrated.
Activation of rapid oestrogen signalling in aggressive human breast cancers (2012)

Oestrogen receptors can mediate rapid activation of cytoplasmic signalling cascades by recruiting Src and PI3K. However, the involvement of this pathway in breast cancer remains poorly defined. We have previously shown that methylation of ERα is required for the formation of the ERα/Src/PI3K complex and that ERα is hypermethylated in a subset of breast cancers. Here, we used Proximity Ligation Assay to demonstrate that this complex is present in the cytoplasm of breast cancer cell lines as well as formalin-fixed, paraffin-embedded tumours. Of particular interest, the analysis of 175 breast tumours showed that overexpression of this complex in a subset of breast tumours correlates to the activation of the downstream effector Akt. Survival analysis revealed that high expression of this complex is an independent marker of poor prognosis and associated with reduced disease-free survival. Our data introduces the new concept that the rapid oestrogen pathway is operative in vivo. It also provides a rationale for patient stratification defined by the activation of this pathway and the identification of target therapies.
Omeprazole and clopidogrel: Should clinicians be worried? (2010)

The US Food and Drug Administration has issued a warning that omeprazole (Prilosec) reduces the antiplatelet activity of clopidogrel (Plavix) by about 50%. However, the warning is based largely on ex vivo data. Preliminary results from a randomized clinical trial revealed no effect on cardiovascular outcomes when omeprazole was given with clopidogrel. We recommend that physicians continue to prescribe a proton pump inhibitor for patients receiving dual antiplatelet therapy who are at risk of gastrointestinal bleeding or have an indication for use of a proton pump inhibitor.
Electromagnetic Forming Processes: Material Behaviour and Computational Modelling (2014)

Electromagnetic Forming is a very promising high-speed forming process. However, designing these processes remains quite intricate as it leads to deal with strongly coupled multiphysics process and thus requires the use of computational models. We present here the main features of the numerical model which we are currently developing to model this process. Accurate knowledge of constitutive law parameters for material at high strain rates remains quite difficult to access. We thus introduce here a procedure which has been developed in order to deal with identification of these parameters.
P2H-4 Small (3x2.5mm&#x000B2;) Surface Acoustic Wave Duplexer for W-CDMA with Good Temperature and Frequency Characteristics (2007)

Small sized surface acoustic wave (SAW) duplexer for wide band code division multiple access (W- CDMA) system with a good temperature coefficient of frequency (TCF) and good frequency characteristics has been required. However, the size of conventional SAW duplexer for W-CDMA using Al-electrode/50-70degYX- LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> is large (3.8x3.8 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) and its TCF is not good (-80ppm/degC). So, this duplexer can't satisfy its severe specifications in the all temperature range from -30 to 85degC. When SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> film is deposited on this substrate to improve the TCF, the frequency characteristics is deteriorated by convex portions on the SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> surface caused by SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> sputtering. This time, by applying a flip chip bonding process, a fiattened-SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Cu- electrode/substrate structure, and a YX-LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> substrate, a small sized (3x2.5x1.2 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> ) SAW duplexer having good characteristics (such as low insertion loss and large attenuation) and good TCF has been realized for the first time. Here, the SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> film is used to improve the TCF, the flattened-SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> to obtain high Q, the thick Cu- electrode to obtain the large reflection coefficient, and the YX-LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> substrate to obtain the large coupling factor and not to generate Rayleigh wave which causes spurious at the SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> of 0.3lambda and the Cu-electrode of 0.05lambda.
Reactive ion etching of LiNbO3 (1981)

We describe the reactive ion etching of LiNbO3 in gas mixtures containing CCl2F2, CF4, O2, and Ar. The effects of gas composition and pressure, in the range 1–10-μm total pressure are discussed. Because it is possible to replicate fine features (∼2000 Å) with control of etch profiles, we expect the process to be used for three-dimensional patterning of LiNbO3 for electro-optic and acoustic-optic devices.
Switch short-circuit fault detection algorithm based on drain-to-source voltage monitoring for a fault tolerant DC/DC converter (2016)

Switch Short-Circuit Fault (SSCF) is one of the most harmful failure mode in a DC-DC Converter. As a consequence, the earliest identification should be ensured in order to avoid the shutdown of the whole system. In this paper, a fast and simple method is introduced for detecting and identifying the faulty leg caused by a SSCF in a six-phase Interleaved Boost Converter (IBC) for Fuel Cell Vehicle application. The proposed detection technique is based on a comparison between the power MOSFET Drain-to-Source Voltage V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS</sub> in ON state with an adjustable threshold voltage V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS-ON-TH</sub> by using only control pulses and driver information. After the fault detection, and its isolation, remedial actions by control reconfiguration methodology are applied to allow the DC-DC converter to operate in pre-fault conditions. To confirm the effectiveness of the suggested approach, simulation tests are reported using Matlab/Simulink <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">©</sup> and ANSYS/Simplorer <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">©</sup> . Also, comparative study between the developed voltage-based method and current-based method is provided by numerical simulations. The results obtained by the proposed method indicate that the SSCF can be detected not only in switch ON state but also in OFF state by adding some modifications to the proposed algorithm. In switch OFF state, the results prove similar behavior detection time for both the methods which detects fault occurrence in less than one switching period. By contrast, for the ON state, the proposed method detects the failure for a 100 kHz frequency using the voltage information provided by the driver. The advantage of this method is that the detections are valid in both states (ON and OFF), the suggested algorithm is simple, and easily configurable.
Role of JAK3 in CD40-Mediated Signaling (1998)

CD40 is a member of the tumor necrosis factor receptor family and plays an important role in B-cell survival, growth, differentiation, and isotype switching. Recently, CD40 has been shown to associate with JAK3, a member of the family of Janus Kinases, which are nonreceptor protein kinases involved in intracellular signaling mediated by cytokines and growth factors. To investigate the role of JAK3 in CD40-mediated signaling, we studied the effect of CD40 stimulation on B-cell proliferation, IgE isotype switching, and upregulation of surface expression of CD23, ICAM-1, CD80, and LT-alpha in JAK3-deficient patients. Our studies show that stimulation of B cells with monoclonal antibody to CD40 in the presence of interleukin-4 (IL-4) or IL-13 resulted in similar responses in JAK3-deficient patients and normal controls. This suggests that JAK3 is not essential for CD40-mediated B-cell proliferation, isotype switching, and upregulation of CD23, ICAM-1, CD80, and LT-alpha surface expression.
Large‐scale capture and partial purification of plasmid DNA using anion‐exchange membrane capsules (2003)

The demand for larger quantities of high-purity plasmids continues to increase. Substantial quantities of plasmid DNA are needed to support viral and plasmid-based gene-therapy programmes, including drug delivery, preclinical and clinical studies and production of DNA vaccines. Reliance on fermentation, which generates large lysate volumes, for producing the needed quantities of plasmid DNA is becoming more widespread. Development of an efficient capture-unit operation for very large plasmid DNA molecules from these large lysate volumes can present a considerable challenge. Use of conventional chromatographic beaded media for plasmid capture is problematic, owing to their restrictive pores, which limits access of the large DNA molecules to only those binding sites on the beads' outer surface. Anion-exchange membranes, on the other hand, have large convective pores that allow the plasmid DNA to readily access all of the membrane's anionic binding sites, even at very high flow rates. The convenience of anion-exchange membranes, configured in ready-to-use capsules, can greatly simplify large-scale plasmid purification strategies. The effectiveness of membrane-based technology for the capture of a pCAT reporter plasmid from large volumes of clarified Escherichia coli lysate was demonstrated. The captured and eluted plasmid pool was found to have been concentrated 10-fold with a reduction in endotoxin of four orders of magnitude.
Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression (2017)

Rett syndrome (RS) is a debilitating neurological disorder affecting mostly girls with heterozygous mutations in the gene encoding the methyl-CpG-binding protein MeCP2 on the X chromosome. Because restoration of MeCP2 expression in a mouse model reverses neurologic deficits in adult animals, reactivation of the wild-type copy of MeCP2 on the inactive X chromosome (Xi) presents a therapeutic opportunity in RS. To identify genes involved in MeCP2 silencing, we screened a library of 60,000 shRNAs using a cell line with a MeCP2 reporter on the Xi and found 30 genes clustered in seven functional groups. More than half encoded proteins with known enzymatic activity, and six were members of the bone morphogenetic protein (BMP)/TGF-β pathway. shRNAs directed against each of these six genes down-regulated X-inactive specific transcript (XIST), a key player in X-chromosome inactivation that encodes an RNA that coats the silent X chromosome, and modulation of regulators of this pathway both in cell culture and in mice demonstrated robust regulation of XIST. Moreover, we show that Rnf12, an X-encoded ubiquitin ligase important for initiation of X-chromosome inactivation and XIST transcription in ES cells, also plays a role in maintenance of the inactive state through regulation of BMP/TGF-β signaling. Our results identify pharmacologically suitable targets for reactivation of MeCP2 on the Xi and a genetic circuitry that maintains XIST expression and X-chromosome inactivation in differentiated cells.
NAC Family Proteins NARS1/NAC2 and NARS2/NAM in the Outer Integument Regulate Embryogenesis in<i>Arabidopsis</i> (2008)

Seed morphogenesis consists of embryogenesis and the development of maternal tissues such as the inner and outer integuments, both of which give rise to seed coats. We show that expression of chimeric repressors derived from NAC-REGULATED SEED MORPHOLOGY1 and -2 (NARS1 and NARS2, also known as NAC2 and NAM, respectively) caused aberrant seed shapes in Arabidopsis thaliana. Double knockout mutant nars1 nars2 exhibited abnormally shaped seeds; moreover, neither nars1 nor nars2 produced abnormal seeds, indicating that NARS1 and NARS2 redundantly regulate seed morphogenesis. Degeneration of the integuments in nars1 nars2 was markedly delayed, while that of the wild type occurred around the torpedo-shaped embryo stage. Additionally, nars1 nars2 showed a defect in embryogenesis: some nars1 nars2 embryos were developmentally arrested at the torpedo-shaped embryo stage. Unexpectedly, however, neither NARS1 nor NARS2 was expressed in the embryo at this stage, although they were found to be expressed in the outer integument. Wild-type pistils pollinated with nars1 nars2 pollen generated normal seeds, while the reverse crossing generated abnormal seeds. Taken together, these results indicate that NARS1 and NARS2 regulate embryogenesis by regulating the development and degeneration of ovule integuments. Our findings suggest that there is an intertissue communication between the embryo and the maternal integument.
Transparent Persistence with Java Data Objects (2003)

Flexible and performant Persistency Service is a necessary component of any HEP Software Framework. The building of a modular, non-intrusive and performant persistency component have been shown to be very difficult task. In the past, it was very often necessary to sacrifice modularity to achieve acceptable performance. This resulted in the strong dependency of the overall Frameworks on their Persistency subsystems. Recent development in software technology has made possible to build a Persistency Service which can be transparently used from other Frameworks. Such Service doesn't force a strong architectural constraints on the overall Framework Architecture, while satisfying high performance requirements. Java Data Object standard (JDO) has been already implemented for almost all major databases. It provides truly transparent persistency for any Java object (both internal and external). Objects in other languages can be handled via transparent proxies. Being only a thin layer on top of a used database, JDO doesn't introduce any significant performance degradation. Also Aspect-Oriented Programming (AOP) makes possible to treat persistency as an orthogonal Aspect of the Application Framework, without polluting it with persistence-specific concepts. All these techniques have been developed primarily (or only) for the Java environment. It is, however, possible to interface them transparently to Frameworks built in other languages, like for example C++. Fully functional prototypes of flexible and non-intrusive persistency modules have been build for several other packages, as for example FreeHEP AIDA and LCG Pool AttributeSet (package Indicium).
Editorial Comment (1979)

No AccessJournal of Urology1 Mar 1979Editorial Comment J.W.D. J.W.D. J.W.D. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)56774-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 121(3), p. 332 © 1979 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 121Issue 3March 1979Page: 332 Advertisement Copyright & Permissions© 1979 by The American Urological Association Education and Research, Inc.MetricsAuthor Information J.W.D. More articles by this author Expand All Advertisement Loading ...