gebhart/patrepeval huggingface dataset:
PDK1 Protein Phosphorylation at Thr354 by Murine Protein Serine-Threonine Kinase 38 Contributes to Negative Regulation of PDK1 Protein Activity (2012)

Murine protein serine-threonine kinase 38 (MPK38) is a member of the AMP-activated protein kinase-related serine/threonine kinase family, which acts as cellular energy sensors. In this study, MPK38-induced PDK1 phosphorylation was examined to elucidate the biochemical mechanisms underlying phosphorylation-dependent regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) activity. The results showed that MPK38 interacted with and inhibited PDK1 activity via Thr(354) phosphorylation. MPK38-PDK1 complex formation was mediated by the amino-terminal catalytic kinase domain of MPK38 and the pleckstrin homology domain of PDK1. This activity was dependent on insulin, a PI3K/PDK1 stimulator, as well as various apoptotic stimuli, including TNF-α, H(2)O(2), thapsigargin, and ionomycin. MPK38 inhibited PDK1 activity in a kinase-dependent manner and alleviated PDK1-mediated suppression of TGF-β (or ASK1) signaling, probably via the phosphorylation of PDK1 at Thr(354). In addition, MPK38-mediated inhibition of PDK1 activity was accompanied by the modulation of PDK1 binding to its positive and negative regulators, serine/threonine kinase receptor-associated protein and 14-3-3, respectively. Together, these findings suggest an important role for MPK38-mediated phosphorylation of PDK1 in the negative regulation of PDK1 activity.
Sonochemical Preparation of a Nanostructured Bifunctional Catalyst (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSonochemical Preparation of a Nanostructured Bifunctional CatalystGennady Dantsin and Kenneth S. SuslickView Author Information School of Chemical Sciences University of Illinois at Urbana-Champaign 600 S. Mathews Avenue, Urbana, Illinois 61801 Cite this: J. Am. Chem. Soc. 2000, 122, 21, 5214–5215Publication Date (Web):May 12, 2000Publication History Received8 December 1999Published online12 May 2000Published inissue 1 May 2000https://pubs.acs.org/doi/10.1021/ja994300whttps://doi.org/10.1021/ja994300wrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views664Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Bubbles,Catalysts,Hydrocarbons,Nanoparticles Get e-Alerts
Segmented polyurethane: A polyether polymer. An initial evalution for biomedical applications (1968)

Abstract A segmented polyurethane elastomer, originally developed for elastic thread, is now being used for molded prostheses. Chemical, mechanical, and biological properties are described. Hydrolytic stability of this polymer is compared to that of a polyester urethan. Experience with the material used in components of an experimental heart‐assist pump has shown excellent flex endurance, wear resistance, and intravascular acceptability.
Interleukin-1 receptor antagonist therapy and induction of anterior chamber-associated immune deviation-type tolerance after corneal transplantation. (2000)

Promotion of OVA-specific ACAID by IL-1ra suggests that suppression of IL-1-mediated mechanisms contributes to recovery of the anterior segment's immunosuppressive microenvironment at least 1 month earlier than would otherwise be seen after corneal transplantation. However, IL-1ra treatment does not alter induction of donor-specific ACAID after transplantation, suggesting that its anti-inflammatory activities do not lead to an ACAID-inducing signal per se. This suggests that IL-1ra promotes graft survival almost exclusively by virtue of suppressing inflammation and not by directly promoting tolerance or antigen-specific regulatory pathways.
Communication mechanism on autonomous objects (1992)

article Free Access Share on Communication mechanism on autonomous objects Author: Yutaka Ishikawa View Profile Authors Info & Claims ACM SIGPLAN NoticesVolume 27Issue 10Oct. 1992 pp 303–314https://doi.org/10.1145/141937.141962Online:31 October 1992Publication History 5citation248DownloadsMetricsTotal Citations5Total Downloads248Last 12 Months4Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Films, Manufacture (2002)

Abstract This article describes the methods and materials used in the commercial manufacture of polymer film products. Techniques for cast and oriented films using a variety of film‐making equipment are discussed and explained. The manufacturing process is broken down into a series of critical process steps to describe the function of each in the film‐making process and the impact of each on the film properties produced. Both extrusion and solvent‐based casting methods are described and a description of film‐finishing processes is given.
Splitting-merging Clustering Algorithm for Collaborative Filtering Recommendation System (2018)

Collaborative filtering (CF) is a well-known and successful filtering technique that has its own limits, especially in dealing with highly sparse and large-scale data. To address this scalability issue, some researchers propose to use clustering methods like K-means that has the shortcomings of having its performances highly dependent on the manual definition of its number of clusters and on the selection of the initial centroids, which leads in case of ill-defined values to inaccurate recommendations and an increase in computation time. In this paper, we will show how the Merging and Splitting clustering algorithm can improve the performances of recommendation with reasonable computation time by comparing it with K-means based approach. Our experiment results demonstrate that the performances of our system are independent on the initial partition by considering the statistical nature of data. More specially, results in this paper provide significant evidences that the proposed splitting-merging clustering based CF is more scalable than the well-known K-means clustering based CF.
The Cycle of Violence (1989)

Despite widespread belief that violence begets violence, methodological problems substantially restrict knowledge of the long-term consequences of childhood victimization. Empirical evidence for this cycle of violence has been examined. Findings from a cohort study show that being abused or neglected as a child increases one's risk for delinquency, adult criminal behavior, and violent criminal behavior. However, the majority of abused and neglected children do not become delinquent, criminal, or violent. Caveats in interpreting these findings and their implications are discussed in this article.
Ruthenium(<scp>II</scp>) Terdentate CNN Complexes: Superlative Catalysts for the Hydrogen‐Transfer Reduction of Ketones by Reversible Insertion of a Carbonyl Group into the RuH Bond (2005)

Very low loading and short reaction times are characteristic features of the quantitative reduction of different ketones using 2-propanol and terdentate [RuX(CNN)(dppb)] (X=H, Cl (see structure); dppb=Ph2P(CH2)4PPh2) complexes prepared from 6-(4′-methylphenyl)-2-pyridylmethylamine. The reduction apparently takes place by reversible insertion of the substrate into the RuH bond, thus leading to a RuII alkoxide.
Minimization of delay and crosstalk in high-speed VLSI interconnects (1992)

Design optimization of time responses of high-speed VLSI interconnects modeled by distributed coupled transmission line networks is presented. The problem of simultaneous minimization of crosstalk, delay and reflection is formulated into minimax optimization. Design variables include physical/geometrical parameters of the interconnects and parameters in terminating/matching networks. A recently published simulation and sensitivity analysis technique for multiconductor transmission lines is expanded to directly address the VLSI interconnect environment. The new approach permits efficient physical/geometrical oriented interconnect design using exact gradient based minimax optimization. Examples of interconnect optimization demonstrate significant reductions of crosstalk, delay, distortion and reflection at all vital connection ports. The technique developed is an important step towards optimal design of circuit interconnects for high-speed digital computers and communication systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Antibacterial, antioxidant and tyrosinase-inhibition activities of pomegranate fruit peel methanolic extract (2012)

The present study showed that the tested pomegranate peels exhibited strong antibacterial, antioxidant and tyrosinase-inhibition activities. These results suggest that pomegranate fruit peel could be exploited as a potential source of natural antimicrobial and antioxidant agents as well as tyrosinase inhibitors.
A Prospective Single-Blind Randomized Controlled Study of use of Hyaluronic Acid Nasal Packs in Patients after Endoscopic Sinus Surgery (2006)

Merogel nasal packing has no significant beneficial or detrimental effect in terms of synechia, edema, or infection when placed in the middle meatus after ESS.
Broadband semiloop antenna (2002)

Abstract An unbalanced loop antenna of simple construction is proposed for broadband linearly polarized applications. By introducing a gap in a half loop mounted vertically over a ground plane, the bandwidth of the antenna can be substantially increased relative to its classical balanced version. The antenna presented here has a bandwidth of 30% for a maximum −10‐dB return loss, and is fed directly from a coaxial cable without the need for a balun. Numerical and experimental results show that the antenna can cover the entire PCN, UMTS, and IMT2000 frequency allocations and also offer the prospect for reduced SAR. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 34: 233–234, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10425
Optimising element choice for nanoparticle radiosensitisers (2015)

There is considerable interest in the use of heavy atom nanoparticles as theranostic contrast agents due to their high radiation cross-section compared to soft tissue. However, published studies have primarily focused on applications of gold nanoparticles. This study applies Monte Carlo radiation transport modelling using Geant4 to evaluate the macro- and micro-scale radiation dose enhancement following X-ray irradiation with both imaging and therapeutic energies on nanoparticles consisting of stable elements heavier than silicon. An approach based on the Local Effect Model was also used to assess potential biological impacts. While macroscopic dose enhancement is well predicted by simple absorption cross-sections, nanoscale dose deposition has a much more complex dependency on atomic number, with local maxima around germanium (Z = 32) and gadolinium (Z = 64), driven by variations in secondary Auger electron spectra, which translate into significant variations in biological effectiveness. These differences may provide a valuable tool for predicting and elucidating fundamental mechanisms of these agents as they move towards clinical application.
An affinity/avidity model of peripheral T cell regulation (2005)

We show in these studies that Qa-1–dependent CD8(+) T cells are involved in the establishment and maintenance of peripheral self tolerance as well as facilitating affinity maturation of CD4(+) T cells responding to foreign antigen. We provide experimental evidence that the strategy used by the Qa-1–dependent CD8(+) T cells to accomplish both these tasks in vivo is to selectively downregulate T cell clones that respond to both self and foreign antigens with intermediate, not high or low, affinity/avidity. Thus, the immune system evolved to regulate peripheral immunity using a unified mechanism that efficiently and effectively permits the system to safeguard peripheral self tolerance yet promote the capacity to deal with foreign invaders.
GENIE: A Hybrid Genetic Algorithm for Feature Classification in Multi-Spectral Images (2000)

We consider the problem of pixel-by-pixel classification of a multi-spectral image using supervised learning. Conventional supervised classification techniques such as maximiun likelihood classifcation and less conventional ones such as neural networks, typically base such classifications solely on the spectral components of each pixel. It is easy to see why: the color of a pixel provides a nice, bounded, fixed dimensional space in which these classifiers work well. It is often
The Demise of the Declaratory Judgment Action as a Device for Testing the Insurer's Duty to Defend: A Postscript (1975)

For years the conflict of interest problem that occasionally arose out of the defense of an insured by his liability carrier denying coverage under the policy was, for the most part ignored. Now, within the last decade, it has surfaced as one of the most litigated questions in the field of insurance law. In the last issue of this Review, this author attempted an exegesis of Motorists Mutual Insurance Co. v. Trainor, then the latest pronouncement on the subject by the Supreme Court of Ohio. Soon after that article was published, the Supreme Court again addressed itself to the problem in State Farm Fire & Casualty Co. v. Pildner. While the majority opinion in that case sustains the thesis expressed in the aforementioned article, the concurring opinion suggests a radical departure. This postscript, then, will examine Pildner in the light of Trainor, and attempt a critical analysis of the Pildner concurring opinion.
Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action. (1996)

Activation of photoreceptor and olfactory cyclic nucleotide-gated (CNG) channels involves distinct ligand-binding and channel-gating reactions. To dissociate binding from gating, we identified the first competitive antagonists of CNG channels: specific phosphorothioate derivatives of cAMP and cGMP. We also identified membrane-permeant forms of these molecules that are antagonists and that will be useful for elucidating physiological roles for CNG channels in intact cells. The photoreceptor and olfactory CNG channels determine which of the phosphorothioate derivatives are agonists and which are antagonists based on different structural features of the ligand. The photoreceptor channel uses the nature of the purine ring (adenine vs guanine), whereas the olfactory channel uses the isomeric position of the thiophosphate S atom (Rp vs Sp). Interestingly, the same ligand, Rp-cGMPS, has opposite effects on the two channels, activating the photoreceptor channel and antagonizing the olfactory channel. Because Rp-cGMPS binds to both channels but activates only one, the channels must differ in a protein region that couples binding to gating. Chimeric photoreceptor and olfactory CNG channels reveal that the cytoplasmic C-terminal domain determines whether bound ligand activates the channel successfully. Hence, the C terminus contains not only the cyclic nucleotide-binding site, but also a region that couples ligand binding to channel gating.
REVIEWS (1957)

Journal Article REVIEWS Get access Diderot and Sterne. By ALICE GREEN FREDMAN. Pp. xii+264. New York: Columbia University Press; London: Geoffrey Cumberlege, 1955. 36s. net. D. M. LOW D. M. LOW Search for other works by this author on: Oxford Academic Google Scholar The Review of English Studies, Volume VIII, Issue 29, 1957, Pages 98–101, https://doi.org/10.1093/res/VIII.29.98 Published: 01 January 1957
A Comparison of Some Commonly Used Methods for Detecting Antibodies to Bovine Albumin in Human Serum (1966)

Summary Fifteen human and two rabbit sera that contained anti-bovine serum albumin (BSA) as measured by the ammonium sulfate test were studied with a variety of other methods for detecting antibody. These included radioimmunoelectrophoresis, P-80 precipitin test, microimmunodiffusion, hemagglutination, passive cutaneous anaphylaxis and the Prausnitz-Küstner passive transfer for reaginic activity. The rabbit anti-BSA sera bound amounts of I131-BSA comparable to the human antisera and gave strongly positive reactions when tested with each procedure. Radioimmunoelectrophoresis studies confirmed that each of the human sera selected on the basis of the ammonium sulfate test contained antibodies capable of binding I131-BSA, but among all the other techniques there was considerable variation with regard to their capacity to detect and measure anti-BSA activity in the human sera. The P-80 test revealed that the human sera had reduced precipitating efficiency as compared to similar rabbit anti-BSA sera. Microimmuno-diffusion was relatively insensitive in that it detected antibody in only one human serum. The hemagglutination test was positive in 10 of the 15 sera, but the titers were relatively low and did not reflect the major differences observed with the ammonium sulfate test. Reaginic activity was present in four human sera and only three of these contained γA-globulin which bound I131-BSA when tested with radioimmunoelectrophoresis. Conversely, one human anti-BSA serum contained γA-globulin which bound I131-BSA but did not have reaginic activity. Thus, reaginic activity was not necessarily related to the presence or absence of γA-globulins with the capacity to bind I131-BSA. The passive cutaneous anaphylaxis tests were uniformly negative employing the human anti-BSA sera. Of the techniques used in this study, only radioimmunoelectrophoresis and the ammonium sulfate method detect the primary interaction between antigen and antibody. In contrast, the other in vitro and in vivo tests depend upon measuring secondary events which in varying degree may occur sometime after the primary antigenantibody reaction.
A description of the complete off-track capability curve and its special application (1998)

For the first time the entire curve depicting the off-track capability of a magnetic recording head with inductive-write-wide, magnetoresistive-read-narrow is demonstrated. In contrast to the conventionally used 747 curve, "negative" off-track capability (OTC) is introduced both for theoretical derivations and experimental data. Due to the completeness of the measured 747 curve, more reliable data were obtained and served as known parameters for solving the head parameters w, r, and e (write, read, and erase band width) and the geometric noise to signal ratio constants (k, k/sub 0/, and k'). In addition, more equations were used to ensure the consistency of the solutions. Once the parameters and constants were determined, the calculated 747 curve was constructed. Finally, data track and erase bandwidths were examined by MFM experimentally and, compared with the calculated results, excellent agreement was found, thus validating the proposed method for its special application.
The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera. (1997)

The antifungal antibiotic clotrimazole (CLT) blocks directly and with high potency the Ca2+-activated K+ channels of human erythrocytes, erythroleukemia cells, and ferret vascular smooth muscle cells. We recently reported that CLT inhibits Cl- secretion in human intestinal T84 cells, likely by affecting K+ transport (Rufo, P.A., L. Jiang, S.J. Moe, C. Brugnara, S.L. Alper, and W.I. Lencer. 1996. J. Clin. Invest. 98:2066-2075). To determine if CLT had direct effects on K+ conductances in T84 cells, we selectively permeabilized apical membranes of confluent T84 cell monolayers using the ionophore amphotericin B. This technique permits direct measurement of basolateral K+ transport. We found that CLT and a stable des-imidazolyl derivative inhibited directly two pharmacologically distinct basolateral membrane K+conductances, but had no effect on apical membrane Cl- conductances. The effects of CLT on Cl- secretion were also examined in intact tissue. CLT inhibited forskolin-induced Cl- secretion in rabbit colonic mucosal sheets mounted in Ussing chambers by 91%. CLT also inhibited cholera toxin-induced intestinal Cl- secretion in intact mice by 94%. These data provide direct evidence that CLT blocks Cl- secretion in intestinal T84 cells by inhibition of basolateral K+ conductances, and show that CLT inhibits salt and water secretion from intact tissue in vitro and in vivo. The results further support the suggestion that CLT and its metabolites may show clinical efficacy in the treatment of secretory diarrheas of diverse etiologies.
The Use of Elongate Microbeams of X-Rays for Simulating the Effects of Cosmic Rays on Tissues: A Study of Wound Healing and Hair Follicle Regeneration (1963)

William E. Straile, Herman B. Chase, The Use of Elongate Microbeams of X-Rays for Simulating the Effects of Cosmic Rays on Tissues: A Study of Wound Healing and Hair Follicle Regeneration, Radiation Research, Vol. 18, No. 1 (Jan., 1963), pp. 65-75
Query Expansion and Classification of Retrieved Documents. (1998)

This paper presents different methods tested by the University of Avignon and Bertin at the TREC-7 evaluation. A first section describes several methodologies used for query expansion: synonymy and stemming. Relevance feedback is applied both to the TIPSTER corpora and Internet documents. In a second section, we describe a classification algorithm based on hierarchical and clustering methods. This algorithm improves results given by any Information Retrieval system (that retrieves a list of documents from a query) and helps the users by automatically providing a structured document map from the set of retrieved documents. Lastly, we present the first results obtained with TREC-6 and TREC7 corpora and queries by using this algorithm.