gebhart/patrepeval huggingface dataset:
Landmark Trials in Renal Cancer (2018)

The therapy of kidney cancer has made multiple major advances. Eleven agents are now approved by FDA for treatment of metastatic RCC and one agent is approved for adjuvant therapy for localized high risk disease post nephrectomy. In addition the trials addressing the role of surgery also represent major strides in therapy. All these advances in RCC therapeutics have occurred through clinical trials. This paper is a summary of landmark trials that have been critical in the therapeutic development journey in advancing the care and improving outcomes in kidney cancer. The front line therapies are summarized starting with immunotherapy with high dose interleukin-2 to targeted therapies such as bevacizumab (monoclonal antibody), receptor tyrosine kinases such as sorafenib, sunitinib, and pazopanib and MTOR inhibitors lke temsirolimus in the front line setting. Recently the combinations of ipilimumab and nivolumab as well as bevacizumab and atezolizumab have demonstrated promising efficacy in metastatic disease and these regimens are likely to receive FDA approval. In second line and beyond, therapies such as everolimus, nivolumab, lenvatinib+ everolimus and Cabozantinib have proven benefit. Adjuvant post nephrectomy trials have been conducted with conflicting results. Majority have shonwn lack of benefit, however one study conducted in T3/T4/N1 disease revealed statistically significant disease free survival favoring ajuvant sunitinib therapy leading to FDA approval. This paper summarizes the data from the reported trials and discusses recent developments in RCC therapeutics.
Chaperone-assisted degradation: multiple paths to destruction (2010)

Molecular chaperones are well known as facilitators of protein folding and assembly. However, in recent years multiple chaperone-assisted degradation pathways have also emerged, including CAP (chaperone-assisted proteasomal degradation), CASA (chaperone-assisted selective autophagy), and CMA (chaperone-mediated autophagy). Within these pathways chaperones facilitate the sorting of non-native proteins to the proteasome and the lysosomal compartment for disposal. Impairment of these pathways contributes to the development of cancer, myopathies, and neurodegenerative diseases. Chaperone-assisted degradation thus represents an essential aspect of cellular proteostasis, and its pharmacological modulation holds the promise to ameliorate some of the most devastating diseases of our time. Here, we discuss recent insights into molecular mechanisms underlying chaperone-assisted degradation in mammalian cells and highlight its biomedical relevance.
The Electromotive Force Measurements of Hydrochloric Acid Solutions with and without Sucrose and their Relation to the Rate of Sucrose Hydrolysis<sup>1</sup> (1935)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Electromotive Force Measurements of Hydrochloric Acid Solutions with and without Sucrose and their Relation to the Rate of Sucrose Hydrolysis1Vernon K. Krieble and Fred M. ReinhartCite this: J. Am. Chem. Soc. 1935, 57, 1, 19–22Publication Date (Print):January 1, 1935Publication History Published online1 May 2002Published inissue 1 January 1935https://doi.org/10.1021/ja01304a006RIGHTS & PERMISSIONSArticle Views75Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (433 KB) Get e-Alertsclose Get e-Alerts
Crystal Engineering of Conjugated Oligomers and the Spectral Signature of π Stacking in Conjugated Oligomers and Polymers (2000)

H-bonding was used to alter the molecular packing of a bithiazole oligomer. Comparison of the solid-state UV−vis absorption spectra of the H-bonded oligomer with a related non-H-bonded oligomer allowed for the assignment of the optical signature of π stacking in crystals or ordered aggregates of conjugated oligomers or polymers. The π-stacking interactions give rise to the fine structure frequently observed in the absorption spectra of regioregular, conjugated polymers, including P3AT's, PABTz's, etc.
Count passengers based on Haar-like feature in elevator application (2008)

Present elevator control use button sensors to determine when and where to dispatch an elevator car, which donpsilat use the number of passengers. In this paper, we analyze images from camera to detect how many persons waiting for the elevator or in an elevator. A novel framework is proposed for optimized elevator schedule. Extended Haar-like features and Adaboost are used to train a head-shoulder classifier. Some images are selected from video according to elevator button callings to detect head-shoulder. To reduce false alarms a post process is added after detecting. Experimental results show the proposed method with post process has higher performance than existed methods. The information of passenger number can be send to elevator control system for effective schedule, which can reduce passengers waiting time and elevatorpsilas unnecessary stop, finally save energy and reduce maintain fee.
Acute Doxorubicin Cardiotoxicity Is Associated With p53-Induced Inhibition of the Mammalian Target of Rapamycin Pathway (2008)

These data suggest that doxorubicin treatment induces acute cardiac dysfunction and reduces cardiac mass via p53-dependent inhibition of mTOR signaling and that loss of myocardial mass, and not cardiomyocyte apoptosis, is the major contributor to acute doxorubicin cardiotoxicity.
Expression of <i>Batis maritima</i> methyl chloride transferase in <i>Escherichia coli</i> (1999)

Methyl chloride transferase, a novel enzyme found in several fungi, marine algae, and halophytic plants, is a biological catalyst responsible for the production of atmospheric methyl chloride. A previous paper reports the purification of this methylase from Batis maritima and the isolation of a cDNA clone of the gene for this enzyme. In this paper, we describe the isolation of a genomic clone of the methylase gene and the expression of recombinant methyl chloride transferase in Escherichia coli and compare the kinetic behavior of the wild-type and recombinant enzyme. The recombinant enzyme is active and promotes the production of methyl chloride by E. coli under in vivo conditions. The kinetic data indicate that the recombinant and wild-type enzymes have similar halide (Cl-, Br-, and I-)-binding capacities. Both the recombinant and wild-type enzymes were found to function well in high NaCl concentrations. This high salt tolerance resembles the activity of halobacterial enzymes rather than halophytic plant enzymes. These findings support the hypothesis that this enzyme functions in the control and regulation of the internal concentration of chloride ions in halophytic plant cells.
Switched-Capacitor/Switched-Inductor Structures for Getting Transformerless Hybrid DC–DC PWM Converters (2008)

A few simple switching structures, formed by either two capacitors and two-three diodes (C-switching), or two inductors and two-three diodes (L-switching) are proposed. These structures can be of two types: ldquostep-downrdquo and ldquostep-up.rdquo These blocks are inserted in classical converters: buck, boost, buck-boost, Cuk, Zeta, Sepic. The ldquostep-downrdquo C- or L-switching structures can be combined with the buck, buck-boost, Cuk, Zeta, Sepic converters in order to get a step-down function. When the active switch of the converter is on, the inductors in the L-switching blocks are charged in series or the capacitors in the C-switching blocks are discharged in parallel. When the active switch is off, the inductors in the L-switching blocks are discharged in parallel or the capacitors in the C-switching blocks are charged in series. The ldquostep-uprdquo C- or L-switching structures are combined with the boost, buck-boost, Cuk, Zeta, Sepic converters, to get a step-up function. The steady-state analysis of the new hybrid converters allows for determing their DC line-to-output voltage ratio. The gain formula shows that the hybrid converters are able to reduce/increase the line voltage more times than the original, classical converters. The proposed hybrid converters contain the same number of elements as the quadratic converters. Their performances (DC gain, voltage and current stresses on the active switch and diodes, currents through the inductors) are compared to those of the available quadratic converters. The superiority of the new, hybrid converters is mainly based on less energy in the magnetic field, leading to saving in the size and cost of the inductors, and less current stresses in the switching elements, leading to smaller conduction losses. Experimental results confirm the theoretical analysis.
The distributed boosting algorithm (2001)

In this paper, we propose a general framework for distributed boosting intended for efficient integrating specialized classifiers learned over very large and distributed homogeneous databases that cannot be merged at a single location. Our distributed boosting algorithm can also be used as a parallel classification technique, where a massive database that cannot fit into main computer memory is partitioned into disjoint subsets for a more efficient analysis. In the proposed method, at each boosting round the classifiers are first learned from disjoint datasets and then exchanged amongst the sites. Finally the classifiers are combined into a weighted voting ensemble on each disjoint data set. The ensemble that is applied to an unseen test set represents an ensemble of ensembles built on all distributed sites. In experiments performed on four large data sets the proposed distributed boosting method achieved classification accuracy comparable or even slightly better than the standard boosting algorithm while requiring less memory and less computational time. In addition, the communication overhead of the distributed boosting algorithm is very small making it a viable alternative to the standard boosting for large-scale databases.
Derivatization and purification of acivicin (AT-125, U-42,126). (1981)

Cefsulodin (CFS), a new antipseudomonas cephalosporin, was clinically evaluated for treatment of the Pseudomonas aeruginosa infections in the surgical field to obtain the following results. 1. CFS was administered to total 11 cases of the surgical infections caused by P. aeruginosa, comprising of 5 cases with wound infections, 3 cases with infected burn and 1 case each with muscular abscess, decubitus and postoperative pneumonia in 0.5 approximately 1 g twice a day by intravenous bolus or drip infusion. Good clinical responses were obtained in 9 out of 11 cases (81.8%). 2. Bacteriological responses were observed in all cases. P. aeruginosa was eradicated in 9 cases and suppressed in 2 cases by CFS treatment. However, replacement of pathogens with the other organisms was observed in 6 out of 8 cases caused by P. aeruginosa only. 3. Neither objective and subjective side effects nor abnormalities of laboratory tests associated with CFS treatment were observed. 4. It can be, therefore, concluded that CFS is one of the useful drugs for treatment of the surgical infections caused by P. aeruginosa.
Physical-Layer Authentication for Multi-Carrier Transmission (2014)

We propose a novel physical-layer challenge-response authentication scheme for multi-carrier transmission. This new scheme exploits both the reciprocity and randomness of the phase responses over multi-carrier channels, and ensures strong security since the channel-phase response is very sensitive to the distance between the transmitter and receiver. A binary hypothesis testing approach is formulated for authentication, which shows a close connection to the problem of pseudo-noise (PN) code acquisition. The proposed scheme can achieve desirable authentication performance even at the signal-to-noise ratio of 5 dB for Rayleigh fading channels.
Clinical cerebral microdialysis: a methodological study (2000)

Two adjacent microdialysis catheters that were identical in membrane length, perfusion fluid, and flow rate showed equivalent results. Variations in perfusion fluid and freezing and thawing of samples did not result in differences in substance concentration. Catheter length had a significant impact on substance recovery. Variations in flow rate enabled the relative recovery to be calculated using a modification of the extrapolation-to-zero-flow method. The recovery was approximately 70% at 0.3 microl/minute and 30% at 1 microl/minute (10-mm membrane) for all analytes. Glutamate results obtained with the enzyme analyzer showed good correlation with those from HPLC.
Undetected error probabilities of binary primitive BCH codes for both error correction and detection (1996)

We investigate the undetected error probabilities for bounded-distance decoding of binary primitive BCH codes when they are used for both error correction and detection on a binary symmetric channel. We show that the undetected error probability of binary linear codes can be simplified and quantified if the weight distribution of the code is binomial-like. We obtain bounds on the undetected error probability of binary primitive BCH codes by applying the result to the code and show that the bounds are quantified by the deviation factor of the true weight distribution from the binomial-like weight distribution.
Switched reluctance motor drive systems dynamic performance prediction and experimental verification (1994)

In this first of a set of two companion papers on switched reluctance motor drive systems, the results of using a state space model to predict a motor-drive system dynamic performance characteristics under normal operating conditions are presented. Using this approach, the state space model parameters are determined from series of nonlinear magnetic field solutions, thus accounting for magnetic material nonlinearities and space harmonics due to the motor geometry. The method is applied to a 6/4, 0.15 hp, 5000 r/min switched reluctance motor and resulted in the machine inductances, which compared favorably to measured values. Using these parameters in the state space model, the dynamic performance characteristics of the motor drive system are predicted and verified by comparison to experimental data. In addition, the effects of mutual coupling between motor phases on the analysis results are evaluated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Rabi oscillations in the excitonic ground-state transition of InGaAs quantum dots (2002)

We present measurements and calculations of optical Rabi oscillations in the excitonic ground-state transition of an InGaAs quantum dot ensemble at low temperature. Rabi oscillations which are damped versus pulse area and change period when changing pulse duration are observed. Comparisons with calculations show that the observed damping is not intrinsic to a single dot. Dephasing processes and the biexciton resonance change the amplitude and the period of the oscillations, respectively, while the damping versus pulse area is due to a distribution of transition dipole moments in the ensemble.
Characterization of distinct functional domains of transforming growth factor beta. (1993)

Three distinct isoforms of transforming growth factor beta (TGF-beta) are expressed in mammalian cells. Although many cells respond equivalently to all three isoforms, certain cells respond selectively. Using chimeric proteins in which selected regions of the different isoforms were interchanged, we have identified two distinct functional domains of TGF-beta involved in determining the biological potencies and functions of the molecule. The first domain is important for determining whether TGF-beta can be sequestered by alpha 2-macroglobulin. By replacing aa 45 and 47 of TGF-beta 2 with the corresponding amino acids of TGF-beta 1, sequestration of the TGF-beta molecule by alpha 2-macroglobulin was markedly reduced. The second domain is functionally different from the alpha 2-macroglobulin sequestration site and is important for determining the potency of TGF-beta to inhibit growth of the LS513 human colorectal cancer cell line. Neither the TGF-beta 2/beta 1-(40-47) replacement construct nor a chimera containing aa 1-39 of TGF-beta 2, aa 40-82 of TGF-beta 1, and aa 83-112 of TGF-beta 2 was equivalent to TGF-beta 1 in inhibiting growth of LS513 cells. This fact suggests that additional amino acids outside of the aa 40-82 region are required to specify TGF-beta 1 activity with these cells.
TransSec: Security Image Transportation in Visual Sensor Networks (2012)

Distributed imaging using sensor arrays has grown rapidly over past several years. Because image data is characterized by is high volume, an architecture of two tiered visual sensor network is proposed, where storage nodes gather image data from nearby sensors and process sink's query to transmit a time-specific image. However the importance of storage nodes is attractive to attackers. In this paper, we propose a TransSec protocol to prevent attackers from deleting or distorting a time-specific image. To preserve privacy, we use a binary quadratic equation based technique to encode each image timestamp such that attackers cannot delete sensitive images without knowing their exact timestamp. To preserve integrity, we propose a new checksum chain that allows a sink to verify whether the result of a query contains exactly the data items and recover missing data items.
Aerodynamics of High-Performance Wing Sails (1974)

Some of the primary requirements for the design of wing sails are discussed. In particular, the requirements for maximizing thrust when sailing to windward and tacking downwind are presented. The results of water channel tests on six sail section shapes are also presented. These test results include the data for the double-slotted flapped wing sail designed by David Hubbard for A. F. Di Mauro's IYRU "C" class catamaran Patient Lady II.
Fan-Out Wafer-Level Packaging with highly flexible design capabilities (2010)

We have developed a new Fan-Out Wafer-Level Packaging (FO-WLP) technology with flexible design capabilities for multilayer fan-out redistribution layers (RDLs) connected to the fine-pitch I/O pads of chips. The prototype of a 2.0 mm × 2.0 mm FO-WLP with 25-pin land grid array (LGA) including a 1.6 mm × 1.6 mm microcontroller chip was fabricated and evaluated. Board-level reliability was also confirmed using 5.0 mm × 5.0 mm FO-WLP. This technology is suited for applications in extremely small microcomputer chip/system packaging for ubiquitous computing.
Morphological hand-printed character recognition by a skeleton-matching algorithm (1993)

We study the use of mathematical morphology for handprinted character recognition. Our approach uses the morphological skeleton transform as the shape descriptor. An efficient skeletonmatching algorithm, which renders the similarity between two skeletons as a distance measure, is employed. Based on this distance measure, a character is classified by a minimum distance classifier. The morphological skeleton transform contains complete shape information and is shown as a powerful descriptor for this class of shapes. We also study the pattern spectrum as a shape descriptor for hand-printed characters. However, the pattern spectrum conveys only information about the shape/size distribution of a given object, which turns out to be not very efficient for hand-printed characters. Experimental results demonstrate the efficiency of the skeletonbased approach and the inadequacy of the pattern-spectrum-based approach.
Dual-band Loop Feed with Enhanced Performance (2008)

This paper is aimed on specific problems of electrically small and deep dish parabolic antennas. Since these antennas may suffer with low efficiency authors describe design and optimization of simple dual-band loop prime-focus feed achieving good efficiency for these antennas.
A Q-Band Low-Profile Dual Circularly Polarized Array Antenna Incorporating Linearly Polarized Substrate Integrated Waveguide-Fed Patch Subarrays (2017)

An integrated low-profile dual circularly polarized (dual CP) array antenna operating in the Q-band is proposed in this paper, which is realized by sequentially rotating subarrays comprised linearly polarized (LP) substrate integrated waveguide (SIW)-fed patches. The design methodology and working mechanism of the LP SIW-fed patches is presented first, which is implemented with a two-layer printed circuit board structure where the SIW feeding network is located in the bottom substrate and the patches are on the top substrate. Four subarrays are then arranged according to the requirements of a sequential rotation array for producing CP directive beams. A two-layer SIW feeding network for providing the required amplitude and phase distributions for the four subarrays is designed, which includes two input ports for exciting CP radiation with opposite handedness, respectively. Prototypes of the LP subarray and the integrated dual CP array antenna were fabricated and measured. Good agreement between the simulation and measured results validates the designs. The proposed low-cost and lightweight dual CP antenna owns the advantages of wide useful bandwidth (8.9%), high isolation of more than 19 dB, low profile of less than $0.1\lambda _{0}$ , and good orthogonal polarization discrimination higher than 25 dB.
Shrink induced nanostructures for energy conversion efficiency enhancement in photovoltaic devices (2013)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Bo Zhang, Min Zhang, Keping Song, Qiao Li, Tianhong Cui; Shrink induced nanostructures for energy conversion efficiency enhancement in photovoltaic devices. Appl. Phys. Lett. 8 July 2013; 103 (2): 023104. https://doi.org/10.1063/1.4812184 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search