gebhart/patrepeval huggingface dataset:
First Cp*-Functionalized N-Heterocyclic Carbene and Its Coordination to Iridium. Study of the Catalytic Properties (2008)

A new pentamethylcyclopentadienyl-functionalized N-heterocyclic carbene ligand (Cp*-NHCMe) has been prepared and coordinated to iridium upon reaction with [Ir(μ-Cl)(cod)]2. The chiral Ir complex is obtained as a racemic mixture of the two possible enantiomers, and its crystal structure is described. The new compound shows high catalytic activity toward transfer hydrogenation, β-alkylation of secondary alcohols with primary alcohols, and amination of primary alcohols.
The At-Risk Youth Recreation Project. (1996)

This article describes the results of a project funded by the National Recreation Foundation through the National Recreation and Park Association. Its purposes were ( l) to increase the amount of evidence available about the impact of park and recreation programs on at-risk youth; (2) to develop instrumentation and improve methodologies for undertaking systematic evaluations of these programs; and ( 3) to develop information about the current status of park and recreation programs for at-risk youth.
An approach to the modeling of counter-rotating seam communication links for LEO satellite systems (2004)

Although counter-rotating seam intersatellite links (CRS-ISL) have been considered, its implementation and impact on the low Earth orbit (LEO) satellite networks is rarely discussed. The paper proposes an approach to the modeling of CRS-ISL for LEO satellite systems. The approach is based on the use of readily-available radio frequency (RF) type of antenna for establishing communications between CRS-ISL, and a simple handoff algorithm is put forward to facilitate the handoff process between counter-rotating seams' satellites so as to maintain the CRS-ISL communication path. Through simulations, the impact and presence of CRS-ISL are discussed.
Architectural strategies for an application-specific synchronous multiprocessor environment (1988)

A multiprocessor architecture is presented that is suited for the customized and automated VLSI realization of complex low-to-medium-speed digital signal processing applications. The proposed architecture is constructed from a set of flexible and parameterizable data paths, a selection of powerful control units (for decision-making tasks), and a number of protocols for fast interprocessor communication. The flexible nature of this system allows for an efficient hardware realization utilizing the inherent parallelism of a particular application. The effectiveness of the approach is substantiated with the synthesis of several test vehicles, such as a pitch-extraction algorithm for speech, in terms of the defined architecture.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Analysis of distributed resistance effects in MOS transistors (1989)

A method of modeling the distributed source and drain resistance effects in MOS transistors is discussed. Simulations performed using this technique are validated by comparisons with purpose-built structures. The method is then used to examine a problem which arises with the use of a high-temperature interconnect in three-dimensional silicon-on-insulator technologies. The results show how the resistivity of the interconnect affects the performance of the substrate devices of this technology, and the benefits achievable through further development of the existing interconnect technologies are outlined. Finally, the procedure is used to examine the effect of reduced contact size on standard MOS devices, and results wh1ich give general guidelines to the extent of the effect are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modal field transforming quartz single-mode fibre (1988)

We have made modal field transforming fibres, in which the cross-section of the core changes continuously from circular to elliptical within a few metres. The fabrication method is based on the deformation of a quartz tube during collapse.
Observations of stable layers in the troposphere and stratosphere using VHF radar (1980)

Observations of the Sunset radar located near Boulder, Colorado, reveal order of magnitude enhancements of the signals received on the vertically directed antenna over the signals received nearly simultaneously on the antennas directed off the vertical. These enhancements are caused by Fresnel reflection and Fresnel scattering from thin stable layers. They are most pronounced from stable regions of the atmosphere in the troposphere and stratosphere and especially from the lower stratosphere just above the tropopause. The ability to detect stable layers from enhanced echoes on VHF radars is applied to the determination of the tropopause. It is concluded that the height of the tropopause can be determined within a few hundred meters.
Printing, Peripherals, and Bluetooth in Snow Leopard (2009)

Today more and more features are built into computers than ever before. Most new Macs (except the MacPro and Mac mini) include features such as stereo speakers, decent microphones, and even video cameras all built in and ready to use. Still, oftentimes you need something else or want to improve on what you already have in your computer. Luckily for you, a range of hardware devices exist that can work wonderfully with your Mac (commonly referred to as peripherals). Since you have a Mac, you just need to plug in most of these items, and they work (that is, they're plug and play, as it was intended). However, with the complexity and features available for some of these external devices, occasionally you need to do a little more to get the most out of them. Additionally, these days, many peripherals connect over a network or wirelessly, so rather than plugging something in, you often need to tell your computer to look for it. This chapter addresses all of this, including the following: Printing Bluetooth devices External storage Other external peripherals
Identification and evaluation of new reference genes in Gossypium hirsutumfor accurate normalization of real-time quantitative RT-PCR data (2010)

We have tested the expression stabilities of nine candidate genes in a set of 23 tissue samples from cotton plants divided into five different experimental sets. As a result of this evaluation, we recommend the use of GhUBQ14 and GhPP2A1 housekeeping genes as superior references for normalization of gene expression measures in different cotton plant organs; GhACT4 and GhUBQ14 for flower development, GhACT4 and GhFBX6 for the floral organs and GhMZA and GhPTB for fruit development. We also provide the primer sequences whose performance in qPCR experiments is demonstrated. These genes will enable more accurate and reliable normalization of qPCR results for gene expression studies in this important crop, the major source of natural fiber and also an important source of edible oil. The use of bona fide reference genes allowed a detailed and accurate characterization of the temporal and spatial expression pattern of two MADS-box genes in cotton.
Disruption of phagosomal membranes of normal alveolar macrophages by the H37Rv strain of Mycobacterium tuberculosis. A correlate of virulence. (1984)

The H37Rv and H37Ra strains of Mycobacterium tuberculosis were incubated with normal rabbit alveolar macrophages and examined by electron microscopy at 5 to 6 and 18 to 24 h of incubation. At the 18- to 24-h incubation interval, 60 to 100% of the endocytosed organisms of the H37Rv strain disrupted the phagosomal membranes and appeared free in the cytoplasm of the macrophages. In contrast, the H37Ra strain lacked this putative virulence characteristic, and greater than 99% of the organisms appeared within intact phagosomes. Heating the organisms of the H37Rv strain abrogated to a large extent, but not completely, their capacity to disrupt phagosomal membranes. In the course of the interaction of organisms of the virulent H37Rv strain with phagosomal membranes of normal rabbit alveolar macrophages, adherence of the phagosomal membrane to the surface of the organisms was a prominent feature that was followed by fragmentation and apparent disintegration of the membrane. This potential virulence characteristic could explain why there is essentially no resistance expressed in the lung during the early postinfectious period of primary infection to M. tuberculosis.
Envasado de alimentos mediante recubrimientos comestibles (2001)

Los cambios en los habitos del consumidor, conjuntamente con el auge que estan experimentando las nuevas tecnologias de procesado, han dado lugar a estudios de produccion, caracterizacion y aplicacion de materiales comestibles que puedan desempenar funciones protectoras de los alimentos. Las peliculas comestibles permiten, a la vez que el aumento de la vida util del producto, la reduccion de los residuos generados por el envase, con el consiguiente ahorro energetico que esto supone. En este articulo se presentan las principales propiedades de este tipo de sustancias, asi como sus aplicaciones mas notables en alimentos y algunos de los estudios llevados a cabo para mejorar tanto sus propiedades como su campo de utilizacion
Learning from Demonstration and Correction via Multiple Modalities for a Humanoid Robot (2011)

This paper reports ongoing work that employs multiple demonstration modalities in order to accomplish motion control learning in a multi-staged policy adaptation process. A novel interface for providing tactile guidance to correct learned motion control behaviors is introduced. This interface extends our prior work by making use of a more sophisticated set of tactile sensors, developed by the ROBOSKIN consortium.
NEUTROPHILS ARE ASSOCIATED WITH A FASTER RECOVERY AFTER MUSCLE INJURY (2003)

One of the first observed events after skeletal muscle injury is acute inflammation, which is thought to affect functional recovery. PURPOSE To determine whether neutrophils (PMN) are correlated with functional recovery after muscle injury. METHODS Male Sprague-Dawley rats (n=47, 314±60g) were subjected to an eccentric injury of the tibialis anterior (TA) by stimulating the peroneal nerve while plantar flexing the ankle through a 90° arc. The TA was then immediately injected with either 0.1 mL of dexamethasone (DM) (0.08mg/kg), saline, nandrolone decanoate (ND) (2mg/kg), or sesame oil. Maximal tetanic tension (Po) was used to measure muscle function on days 1 and 3. To quantify PMN accumulation, a muscle extract was obtained and assayed for myeloperoxidase (MPO) activity and results were calculated as U/mg protein. To visualize PMNs, we performed immunohistochemistry (IH) using antibodies against MPO. The data were analyzed by a one-way ANOVA. RESULTS In a preliminary study, our TA injury led to an immediate decrease in Po from 7.88±1.88N to 5.05±0.85N. As expected, Po continued to drop in all four groups one day after injury. By day 3, however, the DM-treated muscles showed a significant increase in Po (5.68±2.37N) compared to the control group (p = 0.02), while the ND-treated muscle continued to deteriorate (1.56±1.08N) compared to controls (p = 0.03). One day after TA injury both our vehicle-control groups had a doubling of MPO specific activity compared to non-injured muscle. Treatment with DM led to a 55\% increase above controls, while ND treatment led to a 35\% decrease of MPO specific activity compared to controls. By Day 3 the MPO activity had returned to the pre-injury level in all groups. IH showed a similar trend. CONCLUSIONS Contrary to our expectations, we observed a relationship between increased amount of intramuscular PMN on day 1 and the recovery of function after muscle injury on day 3. The data suggest that PMNs may prime the muscle to achieve a faster recovery after injury. Funded in part by NIH (K01HD01165) and a grant from NFL Charities to PGDD
Evaluation of Phenoxybenzamine in the CFA Model of Pain following Gene Expression Studies and Connectivity Mapping (2010)

Evaluation of phenoxybenzamine-induced analgesia in the current study lends support to the utility of the Connectivity Map approach for identifying compounds with analgesic properties in the CFA model.
17 Beta-Estradiol Inhibits LDL Oxidation and Cholesteryl Ester Formation in Cultured Macrophages (1990)

The effects of 17 beta estradiol, testosterone, the estradiol benzoate, and probucol on the oxidation kinetics of low density lipoprotein (LDL) in vitro in absorption presence of 10 microM Cu (II) are examined. Changes in the absorption at 234 nm (A234) and fluorescence (Ex340/Em420) are monitored. The kinetics of the changes observed let us suggest a precursor-product relationship between dienes and fluorochromes in the oxidized LDL. The addition of 17 beta estradiol and probucol to LDL results in a prolongation of the lag phase characterized by only insignificant formation of dienes and fluorochromes. The addition of testosterone and estradiol benzoate used as control compounds has no effect on the lag phase and thus no LDL stabilizing effect. Conditioned LDL which was incubated in F-10 medium before exposure to cultured P388D.1 macrophages increases the formation of cytoplasmic lipid droplets and of cellular cholesteryl esters. The LDL stabilizing compounds beta estradiol and probucol (but not testosterone) causes a reduction of the cholesteryl ester content of the cultured macrophages. Protection of LDL particles against oxidative damage apparently results also in lowering of cytoplasmic cholesteryl ester in cultured P388D.1 cells. We conclude that the known antiatherosclerotic potency of 17 beta estradiol may in part result from its LDL stabilizing activity.
5,6-Dihydro-4H-1,3,4-oxadiazines. V. Base-Catalyzed Cyclodehydrohalogenation of 2-(β-Chloroalkyl)carboxylic Acid Hydrazides (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT5,6-Dihydro-4H-1,3,4-oxadiazines. V. Base-Catalyzed Cyclodehydrohalogenation of 2-(β-Chloroalkyl)carboxylic Acid HydrazidesDonald L. Trepanier, Vilmars Sprancmanis, and John N. EbleCite this: J. Med. Chem. 1966, 9, 5, 753–758Publication Date (Print):September 1, 1966Publication History Published online1 May 2002Published inissue 1 September 1966https://pubs.acs.org/doi/10.1021/jm00323a026https://doi.org/10.1021/jm00323a026research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A prospective, randomized study of continuous versus intermittent nebulized albuterol for severe status asthmaticus in children (1993)

In children with impending respiratory failure due to status asthmaticus, continuous nebulization of albuterol is safe and results in more rapid clinical improvement than intermittent nebulization. Respiratory therapy required at the bedside and duration of hospital stay were substantially less for patients receiving continuous nebulization of albuterol, which suggests that continuous nebulization of albuterol is more cost effective than intermittent nebulization.
Effects and cost-effectiveness of pharmacogenetic screening for CYP2D6 among older adults starting therapy with nortriptyline or venlafaxine: study protocol for a pragmatic randomized controlled trial (CYSCEtrial) (2015)

ClinicalTrials.gov: NCT01778907 ; registration date: 22 January 2013.
Plasma MMP‐9 (92 kDa‐MMP) activity is useful in the follow‐up and in the assessment of prognosis in breast cancer patients (2003)

Previously we determined that plasma MMP-9 activity was significantly elevated in breast cancer patients compared to benign mammary pathologies and healthy controls. Now we analyzed its potential usefulness in the follow-up and in the prognosis of these patients. MMP-9 activity was measured by gelatin quantitative zymography in the euglobulin plasma fraction of 46 breast cancer patients in a 38-month follow-up study. Blood samples were obtained before surgery (S1), 1 month after (S2) and every 3 months. The relapse-free survival (RFS) and overall survival (OS) analysis was performed along 56 months in 113 patients using the Kaplan-Meier curves and Cox analysis. In 63% of the S2 analyzed, MMP-9 decreased after surgery. In 44 patients evaluated during the adjuvant period who developed a complete response, MMP-9 decreased compared to their S1, whereas 2 patients showed an enhancement in correlation with lack of response. Further analysis indicated that in all patients who never showed evidence of recurrence, plasma MMP-9 activity remained low, but it increased 1 to 8 months preceding the clinical detection of progression in those patients who relapsed. Kaplan-Meier curves indicated that high levels of plasma MMP-9 activity at the moment of breast cancer diagnosis were associated with a worse OS rate. Cox analysis showed it was not associated with tumor stage or patient's age. Our results, which show a good correlation between plasma MMP-9 activity and the clinical status of each patient, suggest its usefulness as a marker both in the follow-up and in the prognosis of breast cancer patients.
Ion-Channel Biosensors—Part I: Construction, Operation, and Clinical Studies (2010)

This paper deals with the construction and operation of a novel biosensor that exploits the molecular switching mechanisms of biological ion channels. The biosensor comprises gramicidin A channels embedded in a synthetic tethered lipid bilayer. It provides a highly sensitive and rapid detection method for a wide variety of analytes. In this paper, we outline the fabrication and principle of operation of the ion-channel switch (ICS) biosensor. The results of a clinical study, in which the ion-channel biosensor is used to detect influenza A in untreated clinical samples, is presented to demonstrate the utility of the technology. Fabrication of biochip arrays using silicon chips decorated with ¿ink jet¿ printing is discussed. We also describe how such biochip arrays can be used for multianalyte sensing. Finally, reproducibility/stability issues of the biosensor are addressed.
The anxious patient (2013)

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The T4 molecule differentially regulating the activation of subpopulations of T4+ cells. (1987)

It has been demonstrated that the T4+2H4+ subset functioned as a suppressor inducer cell, whereas the reciprocal T4+2H4- subset provided help for B cell Ig production. In the present studies, a series of monoclonal antibodies to cell surface structures expressed on these subsets of cells were examined for their effects on the proliferative and immunoregulatory functions generated in AMLR. We demonstrated that anti-T4 antibody preferentially inhibited the proliferative response of the T4+2H4+ but not T4+2H4- cells against self-MHC antigens. In contrast, anti-T3 and anti-Ia antibodies inhibited the response of both subsets of cells. This subset preference of anti-T4 antibody was not attributable to either the isolation procedures used or a shift in the kinetics of proliferation to autologous self-MHC antigens. Moreover, both IL 2 production and the immunoregulatory function of the T4+2H4+ subset was profoundly inhibited by anti-T4 antibody, whereas the T4+2H4- subset was minimally influenced. In the absence of Ia molecules, T4+2H4+ but not T4+2H4- cell proliferation was inhibited with anti-T4 antibody. Together, these results suggest that the T4 molecule plays a distinct functional role in the differential triggering of subsets of T4+ cells.
Experimental results with a whole body NMR-CT scanner using a resistive magnet. (1984)

A brief explanation is given on various advantageous features of NMR imaging methods for practical diagnostic purposes. A whole-body NMR-CT scanner utilizing a big resistive air-core magnet has been developed in cooperation with the Institute for Solid State Physics, University of Tokyo. This prototype NMR-CT scanner employs the projection-reconstruction-imaging method with a selective excitation technique for slicing. It can provide physicians with high quality proton NMR images within a practicable, acceptable short data-collection time. Typical NMR-CT images of healthy volunteers and patients were obtained in the experiments using this device, and are presented here. Although the images mainly reflect the hydrogen nucleus concentrations of the subjects, they are strongly affected by relaxation times T1 and T2 and also by the the subjects' internal and external bodily activities. The effects of various NMR parameters in the reconstructed images are analyzed and examples showing these parameter effects are demonstrated. Another advantage of NMR imaging shown here, is a sagittal image of a human body, which is difficult to obtain by using an X-ray CT scanner.
Pyrolysis gas chromatography analysis of rubbers and other high polymers (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrolysis gas chromatography analysis of rubbers and other high polymersJohn Chih-An. HuCite this: Anal. Chem. 1977, 49, 4, 537–540Publication Date (Print):April 1, 1977Publication History Published online1 May 2002Published inissue 1 April 1977https://pubs.acs.org/doi/10.1021/ac50012a009https://doi.org/10.1021/ac50012a009research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Clinical Chemistry. Principles and Technics. (1964)

There is a long tradition in
Nuclear localization and cytosolic overexpression of LASP-1 correlates with tumor size and nodal-positivity of human breast carcinoma (2007)

The current data provide evidence that LASP-1 is not exclusively a cytosolic protein, but is also detectable within the nucleus. Increased expression of LASP-1 in vivo is present in breast carcinomas with higher tumor stage and therefore may be related with worse prognosis concerning patients' overall survival.