gebhart/patrepeval huggingface dataset:
Organization of the Chemokine Gene Cluster on Human Chromosome 17q11.2 Containing the Genes for CC Chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES (1999)

To understand the organization of the human CC chemokine gene cluster on chromosome 17q11.2, we determined the nucleotide sequence of a region 181 kb long containing five CC chemokine genes, MPIF-1 (SCYA23), HCC-2 (SCYA15), HCC-1 (SCYA14), LEC (SCYA16), and RANTES (SCYA5), by the random shot-gun method. The four CC chemokine genes, MPIF-1, HCC-2, HCC-1, and LEC, are clustered within a region 40 kb long, whereas the RANTES gene is located approximately 10 kb apart from the four chemokine gene minicluster. These chemokine genes are arranged in the same orientation, and their sizes are relatively long, 3.1 (HCC-1)-8.8 kb (RANTES) when compared with other CC chemokine genes, such as MIP-1alpha/LD78alpha (SCYA3) (1.9 kb) and MCP-1 (SCYA2) (1.5 kb). In contrast to most other human CC chemokine genes that consist of three exons, the MPIF-1 and HCC-2 genes, separated by 12 kb, have four exons. When the nucleotide sequences of the MPIF-1 and HCC-2 genes are compared, they are well conserved, including introns and flanking sequences, except for the middle region of the long first intron, indicating that they have been generated recently in evolutionary terms by duplication. In addition to the CC chemokine genes, more than 30 exons are identified in the sequenced region by similarity search against expressed sequence tags (ESTs) and also by the gene prediction program GenScan. This indicates that the chemokine cluster sequenced in this study is a gene-rich region in the human genome.
Torque Ripple Reduction of Saliency-Based Sensorless Drive Concentrated-Winding IPMSM Using Novel Flux Barrier (2015)

This paper presents a novel flux barrier design of a torque ripple reduction in a saliency-based sensorless drive concentrated-winding interior permanent magnet synchronous motor (IPMSM). The motor is designed for general-purpose sensorless industrial drives and to fulfill the torque ripple requirement with the required maximum torque under the sensorless drive. The designed rotor has a V-shape magnet, and a circular flux barrier at the rotor yoke in the center of N- and S-poles. A 45-N · m-5.5-kW IPMSM has been manufactured to check the design validity. The validity of the proposed design procedure and the expected drive characteristics are experimentally verified by using the prototype.
Performance Improvement by Packet Buffering in Mobile IP Based Networks (2000)

this paper, we propose a new packet buffering method to address such a problem without the scalability problem in Mobile IP based networks. For this purpose, we first investigate the performance of TCP Tahoe without considering packet buffering through the simulation. Our simulation result shows that in most cases, the smooth handoff by the route optimization extension of Mobile IP standard cannot prevent the degradation of TCP performance due to handoffs, although it is designed to reduce the number of packets dropped during the handoff. It also shows that in utilizing the route optimization extension, the TCP performance sometimes becomes worse even than the case of the base Mobile IP unless its smooth handoff makes less than four packets be dropped during the handoff. Such results mean that at least for TCP, the smooth handoff is not useful unless the route optimization extension supports the buffering method, which makes handoffs be transparent to transport layer protocols by recovering the packets dropped during the handoff. We then investigate the effects of packet buffering on the performance of TCP.Wemodify the route optimization extension in order to support packet buffering at the base station, but it is a very minor change. Finally, we discuss some problems that should be addressed to recover the packets dropped during the handoff by the buffering method without giving a worse impact on the performance of TCP,and propose our solution to solve those problems
Carbon nanotube field-effect transistors-an example of an ultra-thin body Schottky barrier device (2004)

We present experimental and simulation results on carbon nanotube field-effect transistors (CNFETs) and discuss their performance in the context of Schottky barriers in a strongly confined geometry. We focus in particular on the impact of the body thickness-the tube diameter-and explain why conventional output characteristics can be obtained in case of CNFETs.
Treatment with tPA Predicts Better Outcome Even if MCA Occlusion Persists (2012)

Although the prognosis of patients with persisting middle cerebral artery occlusion after tissue plasminogen activator administration is known to be poor, patients do better if treated with tissue plasminogen activator vs. those who could not be treated - mainly for late presentation. This may be due to sufficient small vascular territory recanalization despite persistence of large artery occlusion after tissue plasminogen activator treatment.
Bafilomycin A1 Accelerates Chronic Refractory Wound Healing in db/db Mice (2020)

Numerous studies have reported that autophagy plays an important role in chronic wound healing, and enhancement of autophagic activity impairs cutaneous wound healing. The autophagy inhibitor Bafilomycin A1 (Baf A1) inhibits autophagy by preventing the formation of autophagosomes. This study aimed at elucidating the effect of Bafilomycin A1 on chronic refractory wound healing in diabetic mice. A total of 40 diabetic (db/db) mice and 20 nondiabetic (db/m) mice were used in this study. Full-thickness skin defects were generated in the db/db mice models, which were then divided into the following two groups: the nontreated (db/db group) and Baf A1-treated groups (Baf A1 group). The same skin defects were generated in db/m mice (db/m group) to serve as a control. We demonstrated that Baf A1 treatment significantly accelerated wound healing in db/db mice and exerted good healing effects. Moreover, Baf A1 inhibited autophagy in the newly generated epidermis and had minor effects on metabolism in db/db mice. PCNA expression, as detected by immunohistochemistry, and collagen thickness, as detected by Masson's trichrome staining on the 14th day, were higher in the db/m and Baf A1 groups than in the db/db group. In addition, the expression of the proinflammatory cytokine TNF-<i>α</i> in the db/m and Baf A1 groups increased significantly on day 6, and the expression of the anti-inflammatory cytokine IL-10 also increased significantly on day 9. However, there were no significant changes in the expression levels of TNF-<i>α</i> and IL-10 in the db/db group. Therefore, Baf A1 may accelerate diabetic chronic refractory wound healing by promoting cell proliferation, collagen production, and regulating the inflammatory balance.
A high-sensitivity heat flow calorimeter for the investigation of metal-hydrogen reactions (1979)

A new sensitive heat flow calorimeter combined with a hydrogen reactor was developed. Metal-hydrogen reactions can be investigated in the temperature and pressure ranges 243<or=T<or=353K and 1<or=pH2<or=20 MPa, respectively. The calorimeter permits detection of heats of 10 mJ and is suitable for precise measurements of 50 mJ and more in periods of a few seconds up to some 103 s. In its first application the apparatus has been used to determine differential heats of solution of hydrogen in FeTi at 298K.
Migrations of Manuscripts (1998)

(1991). Migrations of manuscripts. The Journal of Legal History: Vol. 12, No. 2, pp. 140-147.
Design and verification of a SAW based chirp spread spectrum system (2002)

We report on the design and performance of a SAW based spread spectrum wireless LAN system which operates in the ISM band at 2.45 GHz. System IF frequency, transmission bandwidth and data rate are 348.8 MHz, 80 MHz, and 2 Mbit/s, respectively. Due to the high processing gain of 22 dB-made possible by the use of SAW devices-and the large transmission bandwidth, the system is insensitive against narrowband fading and noise. We give a brief system overview and present measurements of the data throughput. A comparison with simulation results, focused primarily on measured and modeled channel characteristics, is also presented.
Oxindole Analogs of (5-Hydroxy)-tryptamine and -tryptophan, as Inhibitors of the Biosynthesis and Breakdown of Serotonin<sup>1</sup> (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxindole Analogs of (5-Hydroxy)-tryptamine and -tryptophan, as Inhibitors of the Biosynthesis and Breakdown of Serotonin1K. Freter, H. Weissbach, B. Redfield, S. Udenfriend, and B. WitkopCite this: J. Am. Chem. Soc. 1958, 80, 4, 983–987Publication Date (Print):February 1, 1958Publication History Published online1 May 2002Published inissue 1 February 1958https://pubs.acs.org/doi/10.1021/ja01537a061https://doi.org/10.1021/ja01537a061research-articleACS PublicationsRequest reuse permissionsArticle Views359Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Model of nitric oxide diffusion in an arteriole: impact of hemoglobin-based blood substitutes (2002)

Administration of hemoglobin-based oxygen carriers (HBOCs) frequently results in vasoconstriction that is primarily attributed to the scavenging of endothelium-derived nitric oxide (NO) by cell-free hemoglobin. The ensuing pressor response could be caused by the high NO reactivity of HBOC in the vascular lumen and/or the extravasation of hemoglobin molecules. There is a need for quantitative understanding of the NO interaction with HBOC in the blood vessels. We developed a detailed mathematical model of NO diffusion and reaction in the presence of an HBOC for an arteriolar-size vessel. The HBOC reactivity with NO and degree of extravasation was studied in the range of 2-58 x 10(6) M(-1) x s(-1) and 0-100%, respectively. The model predictions showed that the addition of HBOC reduced the smooth muscle (SM) NO concentration in the activation range (12-28 nM) for soluble guanylate cyclase, a major determinant of SM contraction. The SM NO concentration was significantly reduced when the extravasation of HBOC molecules was considered. The myoglobin present in the parenchymal cells scavenges NO, which reduces the SM NO concentration.
WebFlow - a visual programming paradigm for Web/Java based coarse grain distributed computing (1997)

We present here recent work at NPAC aimed at developing WebFlow – a general purpose Web-based visual interactive programming environment for coarse grain distributed computing. We follow the 3-tier architecture with the central control and integration WebVM layer in tier-2, interacting with the visual graph editor applets in tier-1 (front-end) and the legacy systems in tier-3. WebVM is given by a mesh of Java Web servers such as Jeeves from JavaSoft or Jigsaw from MIT/W3C. All system control structures are implemented as URL-addressable servlets which enable Web browser-based authoring, monitoring, publication, documentation and software distribution tools for distributed computing. We view WebFlow/WEbVM as a promising programming paradigm and co-ordination model for the exploding volume of Web/Java software, and we illustrate it in a set of ongoing application development activities. © 1997 John Wiley & Sons, Ltd.
Quantitation of anti-RNP and anti-Sm antibodies in MCTD and SLE patients by immunoblotting. (1985)

A quantitative immunoblotting assay (QIBA) for the determination of specific antibody titres in human autoimmune sera is described. In this assay, a total HeLa nuclear protein fraction, immobilized on nitrocellulose blot strips, was used as source of antigens and immunoreactive species of autoantibodies were quantitated by an enzyme linked second antibody procedure. Besides being more discriminative, QIBA appeared to be up to 500 times more sensitive than immunodiffusion or immunoelectrophoresis. In this study we used 21 sera from patients with SLE or MCTD for a quantitative analysis of their specific autoantibody content. Within this group, a very diverse spectrum of antibody populations was observed; anti-RNP sera appeared to contain, among others, high tired antibody versus 70K and 31K polypeptides while all (n = 6) anti-Sm sera recognized a 25kD protein doublet. In a follow-up study of two MCTD patients significant flares in specific antibody content could be observed.
Regulation of submaxillary gland androgen-regulated protein 3A via estrogen receptor 2 in radioresistant head and neck squamous cell carcinoma cells (2017)

In summary, our findings provide compelling experimental evidence that HNSCC with SMR3A and ESR2 co-expression have a higher risk for treatment failure and these patients might benefit from clinically well-established drugs targeting estrogen receptor signaling.
ABERRANT RECOMBINATION OF PYRIDOXINE MUTANTS OF <i>Neurospora</i> (1955)

in the progenies.This result was offered in support of a two-phase model of crossing-over.Preliminary observations of the present authors had shown that aging had little or no effect at the late developmental stages at which somatic crossing over occurs, and, in an extensive series of tests, Schwartz's experimental findings were not con- firmed.These results do not disprove the two-phase hypothesis but show that the method chosen to provide supportive evidence will not do so.The size-class distribution of mosaic spots seems to be one of the most consistent features of somatic crossing-over.Aging may somewhat increase the size of the spots.
The Relative Antioxidant Activities of Plant-Derived Polyphenolic Flavonoids (1995)

The relative antioxidant activities, against radicals generated in the aqueous phase, of a range of plant-derived polyphenolic flavonoids, constituents of fruit, vegetables, tea and wine, have been assessed. The results show that compounds such as quercetin and cyanidin, with 3',4' dihydroxy substituents in the B ring and conjugation between the A and B rings, have antioxidant potentials four times that of Trolox, the vitamin E analogue. Removing the ortho-dihydroxy substitution, as in kaempferol, or the potential for electron delocalisation by reducing the 2,3 double bond in the C ring, as in catechin and epicatechin, decreases the antioxidant activity by more than 50%, but these structures are still more effective than alpha-tocopherol or ascorbate. The relative significance of the positions and extents of hydroxylation of the A and B rings to the total antioxidant activity of these plant polyphenolics is demonstrated.
Parameterization of brachytherapy source phase space file for Monte Carlo-based clinical brachytherapy dose calculation (2013)

A common approach to implementing the Monte Carlo method for the calculation of brachytherapy radiation dose deposition is to use a phase space file containing information on particles emitted from a brachytherapy source. However, the loading of the phase space file during the dose calculation consumes a large amount of computer random access memory, imposing a higher requirement for computer hardware. In this study, we propose a method to parameterize the information (e.g., particle location, direction and energy) stored in the phase space file by using several probability distributions. This method was implemented for dose calculations of a commercial Ir-192 high dose rate source. Dose calculation accuracy of the parameterized source was compared to the results observed using the full phase space file in a simple water phantom and in a clinical breast cancer case. The results showed the parameterized source at a size of 200 kB was as accurate as the phase space file represented source of 1.1 GB. By using the parameterized source representation, a compact Monte Carlo job can be designed, which allows an easy setup for parallel computing in brachytherapy planning.
Fully automated determination of solid fat content by pulsed NMR (1974)

Abstract Pulsed NMR has been developed into a quick, accurate fully automated method for the determination of the solid fat content in partially crystallized fats. Accepting a standard deviation of 0.3% solids, the percentage of solids is displayed on a digital voltmeter or printed out 6 sec after placing the sample into the sample holder. To allow for the dead time of the receiver, a correction factor has been introduced giving rise to only small errors (<1%) in the solid fat content. Due to the short measuring time, no temperature control of the sample holder is needed between 10–45 C. Pulsed NMR values can be converted into dilatations and vice versa.
Can a Peripheral Artery Be Used to Detect Venous to Arterial Circulation Shunts? (2007)

The CFA is a simple and reliable alternative to the MCA, but the criteria for diagnosis of a PFO are different.
Teresa de Jesús, primera doctora de la Iglesia: 50 años de una conquista (2020)

Este ano se ha cumplido el 50o. aniversario de la proclamacion de Teresa de Jesus como doctora de la Iglesia por Pablo VI, un acontecimiento sin precedentes, pues era la primera mujer a la que se concedia este titulo en la historia del cristianismo.
Preparation and Characterization of Cu-Coated Nano SiC Composite Particles (2008)

The Cu-coated nano SiC composite particles were prepared by heterogeneous nucleation method. For the heterogeneous nucleation process, the dispered nano SiC particles and the active Cu2O precipitation were both prefabricated. The composite particles were characterized by means of XRD, SEM, EDS, TEM and ED analysis technics. It is found that Cu layers are coated on the nano SiC particles, which are continuous and dense, and partly oxidized to Cu2O, and the oxidation rate can be reduced by improving experimental processes. The investigation on reaction mechanism shows the disproportionating reaction speed of Cu+ can be controlled by adjusting the pH value of reaction solution, which makes the degree of supersaturation of Cu crystallites accord with the conditions of heterogeneous nucleation.
Comparison of various methods for transferring graphene and few layer graphene grown by chemical vapor deposition to an insulating SiO2/Si substrate (2014)

The objective of this study is to compare the results of transferring graphene and few layer graphene (FKG) up to 5 nm thick, grown by chemical vapor deposition (CVD) at a reduced pressure to a SiO2/Si substrate using four different polymer films. The chosen transfer methods are based on the most promising (according to published data) materials: polymethyl methacrylate, polydimethylsiloxane, thermoscotch, and polycarbonate. It is shown that the most promising transfer method (minimum resistance and maximum carrier mobility) lies in the use of polycarbonate thin films with their dissolution in chloroform. In this case, the following parameters are steadily obtained: the graphene and FLG resistance is 250–900 Ω/□ and the carrier mobility is 900–2500 cm2/(V s).
Polyisobutylene RAFT CTA by a Click Chemistry Site Transformation Approach: Synthesis of Poly(isobutylene-<i>b</i>-<i>N</i>-isopropylacrylamide) (2009)

A novel block copolymer, composed of polyisobutylene (PIB) and poly(N-isopropylacrylamide) (PNIPAM) segments, was synthesized. The PIB block was prepared via quasiliving cationic polymerization and end-functionalized by in-situ quenching to yield telechelic halogen-terminated PIB. Azido functionality was obtained by displacement of the terminal halogen through nucleophilic substitution, which was confirmed by both 1H and 13C NMR. Coupling of an alkyne-functional chain transfer agent (CTA) to azido PIB was successfully accomplished through a copper-catalyzed click reaction. Structure of the resulting PIB-based macro-CTA was verified with 1H NMR, FTIR, and GPC, whereas coupling reaction kinetics were monitored by real-time variable temperature (VT) 1H NMR. Subsequently, the function of this macro-CTA was demonstrated by RAFT polymerization of NIPAM for synthesis of the second block. RAFT kinetics was investigated under a variety of reaction conditions using VT NMR, and the resulting block copolymers were characterized by 1H NMR and GPC. Aqueous solution properties were probed by dynamic light scattering confirming the presence of self-assembled aggregates with reversible temperature-sensitive responsiveness.
Dopant spatial distributions: Sample-independent response function and maximum-entropy reconstruction (1997)

We demonstrate the use of maximum entropy based deconvolution to reconstruct boron spatial distribution from the secondary ion mass spectrometry (SIMS) depth profiles on a system of variously spaced boron \ensuremath{\delta} layers grown in silicon. Sample-independent response functions are obtained using a new method that reduces the danger of incorporating real sample behavior in the response. Although the original profiles of different primary ion energies appear quite differently, the reconstructed distributions agree well with each other. The depth resolution in the reconstructed data is increased significantly and segregation of boron at the near surface side of the \ensuremath{\delta} layers is clearly shown.
Asparagine Endopeptidase Is Not Essential for Class II MHC Antigen Presentation but Is Required for Processing of Cathepsin L in Mice (2005)

Class II MHC molecules survey the endocytic compartments of APCs and present antigenic peptides to CD4 T cells. In this context, lysosomal proteases are essential not only for the generation of antigenic peptides but also for proteolysis of the invariant chain to allow the maturation of class II MHC molecules. Recent studies with protease inhibitors have implicated the asparagine endopeptidase (AEP) in class II MHC-restricted Ag presentation. We now report that AEP-deficient mice show no differences in processing of the invariant chain or maturation of class II MHC products compared with wild-type mice. In the absence of AEP, presentation to primary T cells of OVA and myelin oligodendrocyte glycoprotein, two Ags that contain asparagine residues within or in proximity to the relevant epitopes was unimpaired. Cathepsin (Cat) L, a lysosomal cysteine protease essential for the development to CD4 and NK T cells, fails to be processed into its mature two-chain form in AEP-deficient cells. Despite this, the numbers of CD4 and NK T cells are normal, showing that the single-chain form of Cat L is sufficient for its function in vivo. We conclude that AEP is essential for processing of Cat L but not for class II MHC-restricted Ag presentation.