gebhart/patrepeval huggingface dataset:
Pharmacokinetics and milk residues of butorphanol in dairy cows after single intravenous administration (1992)

The pharmacokinetics of butorphanol tartrate were investigated following intravenous administration of 0.25 mg/kg of body weight to six healthy non-lactating Jersey cows. Three lactating Holstein cows also received 0.045 mg of butorphanol/kg of body weight intravenously to determine the extent and duration of drug transfer into milk. A radioimmunoassay technique was used to measure butorphanol concentrations in plasma and milk. The disposition of butorphanol following intravenous administration was characterized by rapid and extensive distribution followed by a slower elimination phase. Apparent volume of distribution was 4.178 +/- 1.145 (mean +/- SD) 1/kg, mean elimination half-life was 82 min, and clearance was 34.6 +/- 7.7 ml/min/kg. Trace quantities of butorphanol were detected in the cow's milk for up to 36 h following administration. These pharmacokinetic data were compared with pharmacokinetic and pharmacodynamic data for butorphanol in other species and for three other potent opioids in related ruminant species.
Interleukin 12 exerts a differential effect on the maturation of neonatal and adult human CD45R0- CD4 T cells. (1994)

It is now recognized that IL-12 plays a predominant role in protective immunity against intracellular pathogens by promoting the development of T helper type 1 (Th1) responses. We here report the unexpected observations that IL-12 exerts differential effects on the maturation of "native" human CD4 T cells isolated from umbilical cord blood or from the blood of healthy adults. After priming in the presence of IL-12, naive cells of adult donors, defined as CD45R0- CD4+ T cells, acquire a Th1 phenotype whereas neonatal cells develop into effector cells producing high levels of IL-4 in addition to IFN-gamma. This effect of IL-12 on neonatal T cells is direct inasmuch as it is observed on highly purified CD4 T cells, however, it is not inhibited by CD8 T cells and natural killer cells. Unstimulated neonatal T cells which have been preincubated with IL-12 before the priming behave like adult T cells and acquire a Th1 phenotype after stimulation in the presence of IL-12. Given that IL-4 is a potent antagonist of Th1 responses, the finding that IL-12 promotes the maturation of neonatal T cells into IL-4 producers may explain the increased susceptibility of neonates to intracellular pathogens and should be taken into account for the development of vaccines to be used in the perinatal period.
Rayleigh-scattering line profiles (1983)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Andrew T. Young and George W. Kattawar, "Rayleigh-scattering line profiles," Appl. Opt. 22, 3668-3670 (1983) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Solar cell efficiency tables (version 26) (2005)

Consolidated tables showing an extensive listing of the highest independently confirmed efficiencies for solar cells and modules are presented. Guidelines for inclusion of results into these tables are outlined and new entries since January, 2005 are reviewed. Copyright © 2005 John Wiley & Sons, Ltd.
Azithromycin Treatment Alters Gene Expression in Inflammatory, Lipid Metabolism, and Cell Cycle Pathways in Well-Differentiated Human Airway Epithelia (2009)

Prolonged macrolide antibiotic therapy at low doses improves clinical outcome in patients affected with diffuse panbronchiolitis and cystic fibrosis. Consensus is building that the therapeutic effects are due to anti-inflammatory, rather than anti-microbial activities, but the mode of action is likely complex. To gain insights into how the macrolide azithromycin (AZT) modulates inflammatory responses in airways, well-differentiated primary cultures of human airway epithelia were exposed to AZT alone, an inflammatory stimulus consisting of soluble factors from cystic fibrosis airways, or AZT followed by the inflammatory stimulus. RNA microarrays were conducted to identify global and specific gene expression changes. Analysis of gene expression changes revealed that the AZT treatment alone altered the gene profile of the cells, primarily by significantly increasing the expression of lipid/cholesterol genes and decreasing the expression of cell cycle/mitosis genes. The increase in cholesterol biosynthetic genes was confirmed by increased filipin staining, an index of free cholesterol, after AZT treatment. AZT also affected genes with inflammatory annotations, but the effect was variable (both up-and downregulation) and gene specific. AZT pretreatment prevented the up-regulation of some genes, such as MUC5AC and MMP9, triggered by the inflammatory stimulus, but the up-regulation of other inflammatory genes, e.g., cytokines and chemokines, such as interleukin-8, was not affected. On the other hand, HLA genes were increased by AZT. Notably, secreted IL-8 protein levels did not reflect mRNA levels, and were, in fact, higher after AZT pretreatment in cultures exposed to the inflammatory stimulus, suggesting that AZT can affect inflammatory pathways other than by altering gene expression. These findings suggest that the specific effects of AZT on inflamed and non-inflamed airway epithelia are likely relevant to its clinical activity, and their apparent complexity may help explain the diverse immunomodulatory roles of macrolides.
A 1.7V Adjustable I/O Interface for Low Voltage Fast SRAMs (1991)

One of the key technologies for future high-density fast SRAMs is an interface circuit that operates at low supply voltage with a high operation speed.
Quantum Imaging (2007)

Quantum imaging has demonstrated two peculiar features: (1) reproducing ghost images in a nonlocal manner, and (2) enhancing spatial resolution of imaging beyond diffraction limit. Both surprises come from the superposition of two-photon amplitudes, a non-classical entity corresponding to different yet indistinguishable alternative ways of triggering a joint photo-detection event.
A chunk caching location and searching scheme in Content Centric Networking (2012)

Content Centric Networking (CCN) is a new network infrastructure around content dissemination and retrieval, shift from host addresses to named data. Each CCN router has a cache to store the chunks passed by it. Therefore the caching strategy about chunk placement can greatly affect the whole CCN performance. This paper proposes an implicit coordinate chunk caching location and searching scheme (CLS) in CCN hierarchical infrastructure. In CLS, there is at most one copy of a chunk cached on the path between a server and a leaf router. This copy is pulled down one level towards the leaf router by a request or pushed up one level towards the server by the cache eviction. Thus, it is possible to store more diverse contents in the whole CCN and improve the network performance. Plus, in order to reduce the server workload and file download time, a caching trail of chunk is created to direct the following request where to find the chunk. Extensive test-bed experiments have been performed to evaluate the proposed scheme in terms of a wide range of performance metrics. The results show that the proposed scheme outperforms existing algorithms.
One-Pot Regioselective Synthesis of 2,6,9-Trisubstituted Adenines (2011)

A series of 2,6,9-substituted adenines were obtained from the easily accessible 5-amino-4-cyanoformimidoyl imidazoles 1, acetic and benzoic anhydrides and primary alkyl amines in a three-steps sequence. Acylation of 1 followed by addition of the amine led to the intermediates 5-amino-4-(N-acyl)formamidino imidazoles 4/5, under mild conditions. Cyclization of 4/5 under reflux in ethanol led to the desired substituted adenine. A preliminary stepwise study led to the development of three general and efficient one-pot methods for the synthesis of adenine derivatives. The one-pot three-step reaction in the presence of DMAP was the most convenient syn-thetic approach.
Identification of 2 Novel Isolates of Hepatitis E Virus in Argentina (2000)

Hepatitis E virus (HEV) has been identified in 2 Argentine patients with acute hepatitis who reported no history of travel to regions in which HEV is considered endemic. These isolates are the first to be identified in South America. By use of degenerate primers from open reading frames 1 and 2, HEV sequences were obtained from these patients' serum and compared with published HEV sequences. The Argentine isolates are different from all previously identified HEV isolates and are most closely related to each other. The Argentine isolates are distinct from the most geographically related isolate from Mexico as well as isolates from other endemic (China, Southeast Asia, and India) and nonendemic (the United States and Europe) regions. Phylogenetic analysis indicate that the Argentine isolates represent a new genotype of HEV, genotype 8, distinct from the Burmese-like genotype 1, Mexican genotype 2, US genotype 3, Chinese/Taiwan genotype 4, and European genotypes 5-7.
Digitally-controlled optimum current tracking scheme of two-paralleled high-power PWM amplifier for magnetic resonance imaging (2002)

This paper presents a two paralleled bridge power conversion circuit using switch-mode power current tracking technique in order to generate a gradient magnetic field in the magnetic resonance imaging (MRI) system. This power amplifier is connected in parallel with the conventional 4-switch type full-bridge PWM power conversion circuit using IGBTs at their inputs/outputs in order to realize further high-power density. A digital optimal control scheme for PWM power conversion circuit requires minimization of the current ripple and improvement of dynamic response characteristics of the current in the gradient coils (GCs). It is proposed in this paper that a unique current tracking control scheme can achieve the research objective. This power amplifier can be easily used in the advanced MRI because the output current waves are not restricted to ramped-square waves and can assume any arbitrary wave forms. It is proved that the proposed technique will highly enlarge the diagnostic target and improve the image quality of MRI.
DECT: the ideal telework access technology (1994)

The paper proposes the Digital European Cordless Telecommunications (DECT) standard as not just the ideal wireless telework access technology, but as the ideal telework access technology. The paper describes the features and capabilities of DECT and explains how it provides fully integrated voice/data services with full support for the IT requirements of teleworkers. It also reports on the activities of ETSI STC RES-03 to standardise DECT access to voice, ISDN, GSM, LAN, Fax, modem, X.25 and other voice/data services. The paper then discusses how a DECT infrastructure for teleworking may be provided and it shows how teleworking in rural and/or remote areas can benefit from DECT technology through the use of DECT based radio in the local loop (RLL), neighbourhood telepoints and through a novel deployment method based on existing analogue PSTN wiring. To assess the real benefits, or otherwise, of teleworking via DECT, the paper discusses the social and work implications to the teleworker, the relationship to the fixed office environment and the cost implications. >
Controlled study of the antiparkinsonian activity and tolerability of cabergoline (1993)

Cabergoline, a new ergoline derivative, is a D2-specific dopaminergic agonist that is more potent and longer-acting than other agonist agents. We conducted a randomized, double-blind study of increasing doses of cabergoline taken once a day. Twenty-five patients with Parkinson's disease taking stable doses of levodopa began cabergoline at 0.5 mg. The dose was escalated at weekly intervals to 1.0 mg in 19 patients, 1.5 mg in 14 patients, 2.0 mg in nine patients, and 2.5 mg in four patients. Treatment continued for 8 weeks after titration. Unified Parkinson's Disease Rating Scale scores, Hoehn and Yahr stage of disease, and computerized measures of motor performance improved significantly with cabergoline treatment. Dose-response effects were not significant. No serious adverse experiences occurred during the 13-week trial, and the side-effect profile mirrored other dopaminergic agonists. Cabergoline appears to be a promising agent in the treatment of Parkinson's disease.
Chromatin Opening and Stable Perturbation of Core Histone:DNA Contacts by FoxO1 (2007)

FoxO1, a member of the forkhead rabdomyosarcoma (FoxO) subfamily of transcription factors, binds DNA via a highly conserved winged-helix "forkhead box" motif used by other regulatory proteins to mediate their effects through chromatin binding and remodeling. To examine how FoxO1 regulates target genes in chromatin, we studied the binding of purified recombinant FoxO1 protein to nucleosome particles and chromatin arrays containing the insulin-like growth factor-binding protein 1 promoter. We found that FoxO1 is able to bind to its cognate sites within the insulin-like growth factor-binding protein 1 promoter on a nucleosome. This binding stably perturbs core histone:DNA contacts extending up- and downstream from sites of FoxO1 binding without disrupting the underlying core particle. FoxO1 is able to harness these capabilities to bind to and de-condense linker histone-compacted chromatin arrays. Chromatin opening by FoxO1 requires both the N and C termini of the protein, which are also required for high affinity core histone binding and, in the case of the N terminus, nucleosome perturbation. We suggest that the chromatin binding and remodeling functions revealed here for FoxO1 endow all FoxO factors with the ability to initiate and dynamically modulate active chromatin states, enabling their diverse roles as gene regulatory factors in metabolism, cell survival, apoptosis, cell cycle progression, DNA repair, and protection against oxidative stress.
A vision for personalized service level agreements in the cloud (2013)

Public Clouds today provide a variety of services for data analysis such as Amazon Elastic MapReduce and Google BigQuery. Each service comes with a pricing model and service level agreement (SLA). Today's pricing models and SLAs are described at the level of compute resources (instance-hours or gigabytes processed). They are also different from one service to the next. Both conditions make it difficult for users to select a service, pick a configuration, and predict the actual analysis cost. To address this challenge, we propose a new abstraction, called a Personalized Service Level Agreement, where users are presented with what they can do with their data in terms of query capabilities, guaranteed query performance and fixed hourly prices.
Tamoxifen induces TGF-β1 activity and apoptosis of human MCF-7 breast cancer cells in vitro (1996)

We report here that the antiestrogen tamoxifen (TAM) induces cell death in human breast cancer cell line MCF-7. We assessed the type of cell death induced by TAM in this breast cancer cell line on the basis of morphological and biochemical characteristics. Dying cells showed morphological characteristics of apoptosis, such as chromatin condensation and nuclear disintegration. DNA isolated from these cells revealed a pattern of distinctive DNA bands on agarose gel. The DNA fragmentation in MCF-7 cells induced by TAM could also be detected by terminal deoxynucleotidyl transferase-mediated dUTP-biotin end labeling. Northern blot hybridization revealed a substantial increase in the amounts of TRPM-2 and TGF-β1 mRNAs in MCF-7 cells after treatment with TAM. In contrast, the mRNA level of the estrogen-induced pS2 gene was strongly suppressed. The biological activity of TGF-β was increased at least fourfold in the media from MCF-7 cells treated with TAM. The results presented in this study suggest that TAM induces apoptosis of MCF-7 cells and it may be mediated by the secretion of active TGF-β. © 1996 Wiley-Liss, Inc.
The role of vitamin A in the glycosylation reactions of glycoprotein synthesis in an ‘<i>in vitro</i>’ system (1987)

Microsomal membrane preparations from rat livers, when incubated with labelled sugar-nucleotides, were shown to synthesize labelled oligosaccharide-lipids in the presence of excess exogenous dolichyl phosphate. Under the incubation conditions defined in the present study, dolichyl pyrophosphoryl(DolPP)GlcNAc2-Man5, DolPPGlcNAc2Man9 and DolPPGlcNAc2Man9Glc3 were the principal oligosaccharide-lipids formed by both control and vitamin A-deficient membranes. However, deficient membranes synthesized 3.2 +/- 0.8 times as much oligosaccharide-lipids and 2.6 +/- 0.7 times as much dolichyl phosphate mannose (DolPMan) and dolichyl phosphate glucose (DolPGlc) as the controls. The transfer of the oligosaccharide chain from the dolichol carrier to the endogenous protein acceptors in vitamin A-deficient microsomes (microsomal fractions) was only 57.5 +/- 9.5% of that of controls. After endo-beta-N-acetylglucosaminidase treatment, only one oligosaccharide species was isolated from both control and vitamin A-deficient microsomal glycoproteins, and was characterized as GlcNAcMan9Glc3. We conclude that the decreased incorporation of labelled mannose and glucose from sugar-nucleotides into the glycoproteins must be due to decreased transfer of GlcNAc2Man9Glc3 from the dolichol carrier to the protein acceptors. This conclusion was further substantiated by the finding that control membranes transferred 4-6 times as much labelled oligosaccharides from exogenously added dolichol-linked substrate (DolPPGlcNAc2Man9Glc3) to endogenous microsomal protein acceptors as compared with the vitamin A-deficient membranes. Attempts to reverse this defect by addition of retinol or retinyl phosphate (a source of retinyl phosphate mannose) to the incubations were unsuccessful.
Effect of oxybutynin on the QTc interval in elderly patients with urinary incontinence (1996)

1. Terodiline, an anticholinergic drug with calcium antagonist properties, is associated with QT prolongation and ventricular arrhythmias. It is not known if oxybutynin, a drug with a similar pharmacological profile, causes QT prolongation. ECGs were obtained before and at least 4 weeks after commencement of oxybutynin (mean daily dose 7.6, range 2.5-10 mg), in 21 elderly (mean age 75, range 58-88 years) patients treated for urinary incontinence. Heart rate, (mean +/- s.d.) 74 +/- 11 vs 69 +/- 11 beats min-1, -6 (-13,2), before vs during oxybutynin therapy, mean difference (95% confidence intervals); PR interval, 168 +/- 27 vs 156 +/- 27 ms, -11 (-26,3); QTc 454 +/- 27 vs 447 +/- 31 ms1/2, -9 (-23,5), and QTc dispersion, QTc max-QTc min, 68 +/- 24 vs 63 +/- 26 ms1/2, -1 (-15,14) were all unaltered by oxybutynin therapy. The lack of an effect on resting heart rate suggests that oxybutynin has little anticholinergic action at cardiac M2 receptors at usually administered doses. Oxybutynin therapy is not associated with QTc interval prolongation and is unlikely to produce ventricular arrhythmias.
Mesoporous Silica Nanoparticles for Intracellular Controlled Drug Delivery (2010)

The application of nanotechnology in the field of drug delivery has attracted much attention in the latest decades. Recent breakthroughs on the morphology control and surface functionalization of inorganic-based delivery vehicles, such as mesoporous silica nanoparticles (MSNs), have brought new possibilities to this burgeoning area of research. The ability to functionalize the surface of mesoporous-silica-based nanocarriers with stimuli-responsive groups, nanoparticles, polymers, and proteins that work as caps and gatekeepers for controlled release of various cargos is just one of the exciting results reported in the literature that highlights MSNs as a promising platform for various biotechnological and biomedical applications. This review focuses on the most recent progresses in the application of MSNs for intracellular drug delivery. The latest research on the pathways of entry into live mammalian and plant cells together with intracellular trafficking are described. One of the main areas of interest in this field is the development of site-specific drug delivery vehicles; the contribution of MSNs toward this topic is also summarized. In addition, the current research progress on the biocompatibility of this material in vitro and in vivo is discussed. Finally, the latest breakthroughs for intracellular controlled drug release using stimuli-responsive mesoporous-silica-based systems are described.
Ontology Modeling and MDA. (2005)

The paper presents Ontology Definition Metamodel (ODM) that enables using Model Driven Architecture (MDA) standards in ontological engineering. Other similar metamodels are based on ontology representation languages, such as RDF(S), DAML+OIL, etc. However, none of these other solutions uses the recent W3C effort -The Web Ontology Language (OWL). In our approach, we firstly define the ODM place in the context of the MDA four-layer architecture and identify the main OWL concepts. Then, we define ODM using Meta-Object Facility (MOF). The relations between similar MOF and OWL concepts are discussed in order to show their differences (e.g. MOF or UML Class and OWL Class). The proposed ODM is a good starting point for defining an OWL-based UML profile that will enable using the well-known UML notation in ontological engineering more extensively.
Why So Few Drugs for Alzheimers Disease? Are Methods Failing Drugs? (2010)

Recent studies of Alzheimer's disease (AD) and other neuropsychiatric drug developments raise questions whether failures of some drugs occur due to flaws in methods. In three case studies of recent AD drug development failures with phenserine, metrifonate, and tarenflurbil we identified methodological lapses able to account for the failures. Errors in complex systems such as drug developments are both almost inescapable due to human mistakes and most frequently hidden at the time of occurrence and thereafter. We propose preemptive error management as a preventive strategy to exclude or control error intrusions into neuropsychiatric drug developments. We illustrate the functions we anticipate for a preemptive error management preventive strategy with a checklist and identify the limitations of this aspect of the proposal with three drug examples. This strategy applies core scientific practices to insure the quality of data within the current context of AD drug development practices.
Simplified Procedure for Extraction and Determination of Vitamin A in Liver (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimplified Procedure for Extraction and Determination of Vitamin A in LiverS. R. Ames, H. A. Risley, and P. L. HarrisCite this: Anal. Chem. 1954, 26, 8, 1378–1381Publication Date (Print):August 16, 1954Publication History Published online1 May 2002Published inissue 16 August 1954https://pubs.acs.org/doi/10.1021/ac60092a039https://doi.org/10.1021/ac60092a039research-articleACS PublicationsRequest reuse permissionsArticle Views248Altmetric-Citations124LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts