gebhart/patrepeval huggingface dataset:
A randomized Phase III trial of etoposide, epirubicin, and cisplatin versus 5‐fluorouracil, epirubicin, and cisplatin in the treatment of patients with advanced gastric carcinoma (1998)

BACKGROUND Gastric carcinoma is a substantial health problem in Turkey, and the majority of patients present with inoperable disease. The aim of this randomized trial was to assess the activity of 5-fluorouracil versus etoposide when combined with epirubicin plus cisplatin in patients with advanced gastric carcinoma (AGC). METHODS In this prospective, randomized, multicenter Phase III study, previously untreated patients with histopathologically proven AGC enrolled after giving informed consent. Patients were allocated to receive either EEP (etoposide 120 mg/m2, epirubicin 30 mg/m2, and cisplatin 40 mg/m2 on Days 1 and 8) or FEP (5-fluorouracil 600 mg/m2, epirubicin 60 mg/m2, and cisplatin 80 mg/m2 on Day 1), and the regimens were to be repeated every fourth week. RESULTS Of a total of 131 eligible patients, 64 were in the EEP group and 67 were in the FEP group. The objective response (complete + partial) rates for evaluable patients (n = 118) were comparable (P = 0.63) in the EEP (20.3%, 12/59) and FEP (15.3%, 9/59) groups, respectively. Actuarial analyses revealed comparable median progression free survival (6 vs. 7 months, P > 0.05) and overall survival (6 vs. 5 months, P > 0.05) duration in the EEP and FEP groups. Both regimens were well tolerated. The most common toxicity was Grade 1-2 nausea with or without vomiting. No chemotherapy-related death occurred. CONCLUSIONS The current study resulted in inadequate response rates for EEP and FEP regimens. Neither combination, as used at the doses and schedules in this study, can be recommended as standard treatment for patients with AGC. Cancer 1998;83:2475-2480. © 1998 American Cancer Society.
Redox Regulation by Thioredoxin and Thioredoxin‐Binding Proteins (2001)

Recent works have shown the importance of reduction/oxidation (redox) regulation in various biological phenomena. Thioredoxin is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys- and constitutes a major thiol reducing system, the thioredoxin system. Thioredoxin plays multiple roles in cellular processes such as proliferation or apoptosis. It also promotes DNA binding of transcription factors such as NF-kappaB, AP-1, p53, and PEBP2. Overexpression of thioredoxin suppresses the degradation of IkappaB and the transactivation of NF-kappaB, whereas overexpression of nuclear-targeted thioredoxin exhibits the enhancement of NF-kappaB-dependent transactivation. ASK1, a MAP kinase kinase kinase mediating the TNF-alpha signal has been identified as a thioredoxin binding protein. Thioredoxin shows an inhibitory effect on the TNF-alpha induced activation of ASK1 and p38 MAP kinase pathway. We identified p40phox as the thioredoxin binding protein-1 (TBP-1) and vitamin D3 up-regulated protein 1 (VDUP1) as the thioredoxin binding protein-2 (TBP-2) by yeast two-hybrid system. TBP-2/VDUP1 negatively regulates the expression and reducing activity of thioredoxin. Thioredoxin interacting proteins may be involved in thioredoxin-mediating redox regulation.
Characterization of the Fatty Acid-responsive Transcription Factor FadR (1997)

In Escherichia coli, fatty acid synthesis and degradation are coordinately controlled at the level of transcription by FadR. FadR represses transcription of at least eight genes required for fatty acid transport and beta-oxidation and activates transcription of at least two genes required for unsaturated fatty acid biosynthesis and the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes, IclR. FadR-dependent DNA binding and transcriptional activation is prevented by long chain fatty acyl-CoA. In the present work, we provide physical and genetic evidence that FadR exists as a homodimer in solution and in vivo. Native polyacrylamide gel electrophoresis and glycerol gradient ultracentrifugation of the purified protein show that native FadR was a homodimer in solution with an apparent molecular mass of 53.5 and 57.8 kDa, respectively. Dominant negative mutations in fadR were generated by random and site-directed mutagenesis. Each mutation mapped to the amino terminus of the protein (residues 1-66) and resulted in a decrease in DNA binding in vitro. In an effort to separate domains of FadR required for DNA binding, dimerization, and ligand binding, chimeric protein fusions between the DNA binding domain of LexA and different regions of FadR were constructed. One fusion, LexA1-87-FadR102-239, was able to repress the LexA reporter sulA-lacZ, and beta-galactosidase activities were derepressed by fatty acids, suggesting that the fusion protein had determinants both for dimerization and ligand binding. These studies support the conclusion that native FadR exists as a stable homo-dimer in solution and that determinants for DNA binding and acyl-CoA binding are found within the amino terminus and carboxyl terminus, respectively.
The Synthesis of 1- and 2-Pyrrolealkylamines (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of 1- and 2-PyrrolealkylaminesWERNER HERZ, D. S. RADEN, and D. R. K. MURTYCite this: J. Org. Chem. 1956, 21, 8, 896–898Publication Date (Print):August 1, 1956Publication History Published online1 May 2002Published inissue 1 August 1956https://pubs.acs.org/doi/10.1021/jo01114a020https://doi.org/10.1021/jo01114a020research-articleACS PublicationsRequest reuse permissionsArticle Views357Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bench Tests for Characterizing the Thermophysical Properties of Type X Special Fire Resistant Gypsum Board Exposed to Fire (2011)

ASTM C1396 Standard Specification for Gypsum Board defines type X special fire resistant gypsum board on the basis of the fire resistance of a load bearing wood framed gypsum partition tested in accordance with ASTM E119 Standard Test Methods for Fire Tests of Building Construction and Materials. Monitoring individual product performance in a wall system fire test presents serious challenges to the manufacturing facility. The expense and complexity of operating an ASTM E119 wall furnace makes it impossible for plants to run the defining test on site. In addition, many factors influence the outcome of a fire resistance test making it difficult to assess the performance of the gypsum board independently of other wall system and laboratory influences. In 2003 the Gypsum Association formed an ad hoc Product Standard Task Group in an attempt to develop an improved definition of type X gypsum board. The new definition had to be equivalent to the current ASTM C1396 specification but based on bench scale tests of the high temperature thermophysical properties of type X gypsum board alone. The tests must also be suitable for use as in-plant quality assurance procedures. A suite of three tests resulted. Their development and correlation to the ASTM E119 test has been documented by the authors in an earlier paper. An analysis of the precision of these three test methods is presented here.
A combination fingerprint classifier (2001)

Fingerprint classification is an important indexing method for any large scale fingerprint recognition system or database as a method for reducing the number of fingerprints that need to be searched when looking for a matching print. Fingerprints are generally classified into broad categories based on global characteristics. This paper describes novel methods of classification using hidden Markov models and decision trees to recognize the ridge structure of the print, without needing to detect singular points. The methods are compared and combined with a standard fingerprint classification algorithm and results for the combination are presented using a standard database of fingerprint images. The paper also describes a method for achieving any level of accuracy required of the system by sacrificing the efficiency of the classifier. The accuracy of the combination classifier is shown to be higher than that of the two state-of-the-art systems tested under the same conditions.
Large variations in the proteolytic formation of a chromogranin A-derived peptide (GE-25) in neuroendocrine tissues (1995)

We have established a radioimmunoassay for GE-25, a peptide present in the C-terminal end of the primary amino acid sequence of chromogranin A where it is flanked by typical proteolytic cleavage sites. Gel-filtration HPLC was used to characterize the molecular sizes of the immunoreactive molecules. The antiserum recognized not only the free peptide but also larger precursors including the proprotein chromogranin A. The tissues with the highest levels of GE-25 immunoreactivity were in decreasing order: the adrenal medulla, the three lobes of the pituitary gland, intestinal mucosa, pancreas and various brain regions. In adrenal medulla and parathyroid gland most of the immunoreactivity was found to be present as intact chromogranin A and some intermediate-sized peptides, without significant amounts of the free peptide. In anterior pituitary, and even more so in intestine, a shift to smaller peptides was seen. In the posterior and intermediate pituitary and in pancreas the predominant immunoreactive material was apparently represented by the free peptide GE-25. In reverse-phase chromatography this peptide eluted exactly like the synthetic standard, which allows a tentative identification as GE-25. In brain tissue the processing of chromogranin A was intermediate, with significant amounts of immunoreactivity corresponding to GE-25 as well as precursor proteins being present. We suggest that in those organs (endocrine pancreas, intermediate and posterior pituitary) where the major hormones are proteolytically processed there is also a concomitant proteolysis of further susceptible peptides. Since GE-25 is apparently formed in vivo and is well conserved between species it seems a good candidate for having specific physiological functions.
Achievement of More Than 25% Conversion Efficiency With Crystalline Silicon Heterojunction Solar Cell (2014)

The crystalline silicon heterojunction structure adopted in photovoltaic modules commercialized as Panasonic's HIT has significantly reduced recombination loss, resulting in greater conversion efficiency. The structure of an interdigitated back contact was adopted with our crystalline silicon heterojunction solar cells to reduce optical loss from a front grid electrode, a transparent conducting oxide (TCO) layer, and a-Si:H layers as an approach for exceeding the conversion efficiency of 25%. As a result of the improved short-circuit current (J <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sc</sub> ), we achieved the world's highest efficiency of 25.6% for crystalline silicon-based solar cells under 1-sun illumination (designated area: 143.7 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ).
Expression and Localization of Epithelial Aquaporins in the Adult Human Lung (2001)

Aquaporins (AQPs) facilitate water transport across epithelia and play an important role in normal physiology and disease in the human airways. We used in situ hybridization and immunofluorescence to determine the expression and cellular localization of AQPs 5, 4, and 3 in human airway sections. In nose and bronchial epithelia, AQP5 is expressed at the apical membrane of columnar cells of the superficial epithelium and submucosal gland acinar cells. AQP4 was detected in basolateral membranes in ciliated ducts and by in situ in gland acinar cells. AQP3 is present on basal cells of both superficial epithelium and gland acinus. In these regions AQPs 5, 4, and 3 are appropriately situated to permit transepithelial water permeability. In the small airways (proximal and terminal bronchioles) AQP3 distribution shifts from basal cell to surface expression (i.e., localized to the apical membrane of proximal and terminal bronchioles) and is the only AQP identified in this region of the human lung. The alveolar epithelium has all three AQPs represented, with AQP5 and AQP4 localized to type I pneumocytes and AQP3 to type II cells. This study describes an intricate network of AQP expression that mediates water transport across the human airway epithelium.
Windows 7 Administrator's Pocket Consultant (2006)

Portable and precise, this pocket-sized guide delivers immediate answers for the day-to-day administration of Windows 7-from desktop configuration and management to networking and security issues. Zero in on core support and maintenance tasks by using quick-reference tables, instructions, and lists. You'll get the precise information you need to solve problems and get the job done-whether at your desk or in the field!
Nondiffracting interference patterns generated with programmable spatial light modulators (1996)

Nondiffracting beams are of interest for optical metrology applications because the size and shape of the beams do not change as the beams propagate. We have created a generating pattern consisting of a linear combination of two nondiffracting patterns. This pattern forms a nondiffracting interference pattern that appears as a circular array of nondiffracting spots. More complicated multiplexed arrays are also constructed that simultaneously yield two different nondiffracting patterns. We generate these Bessel function arrays with a programmable spatial light modulator. Such arrays would be useful for angular alignment and for optical interconnection applications.
Reversible crystalline-amorphous phase transformation in Si nanosheets with lithi-/delithiation (2017)

Silicon (Si) has a large theoretical capacity of 4200 mAhg<sup>-1</sup> and has great potential as a high-performance anode material for Li ion batteries (LIBs). Meanwhile, nanostructures can exploit the potential of Si and, accordingly, many zero-dimensional (0D) and one-dimensional (1D) Si nanostructures have been studied. Herein, we report on two-dimensional (2D) Si nanostructures, Si nanosheets (SiNSs), as anodes for LIBs. These 2D Si nanostructures, with a thickness as low 5 nm and widths of several micrometers, show reversible crystalline-amorphous phase transformations with the lithi-/delithiation by the dimensionality of morphology and large surface area. The reversible crystalline-amorphous phase transformation provides a structural stability of Li<sup>+</sup> insertions and makes SiNSs promising candidates for reliable high-performance LIBs anode materials.
Carotenoids of human colostrum (1990)

Colostrum, the initial postpartum secretion of the breast, ordinarily has a distinct yellow color due to carotenoids of its fat globules. This pigmentation progressively diminishes as milk production increases during the first week of lactation. Identity of these carotenoids was investigated by means of thin-layer chromatography, high performance liquid chromatography and spectral analysis. Alpha- and beta-carotene, lycopene and beta-cryptoxanthin were revealed as major chromogens. A component corresponding to lutein and/or zeaxanthin was also detected by both chromatographic techniques. Extracts of 23 saponified colostrum samples from 10 donors revealed considerable variation in total carotenoid concentration (0.34-7.57 micrograms/ml of colostrum). Multiparous mothers had greater mean colostrum carotenoid concentrations than did the primiparae, 2.18 +/- 1.94 vs 1.14 +/- 1.32 micrograms/ml, respectively. Seven of the eight primiparous donors' samples had little or no yellow color. These findings imply a difference in carotenoid transport by breasts that have lactated as compared to those that have not. The interrelation of carotenoids, lactation and breast cancer is discussed.
Suppression of collagen-induced arthritis by continuous administration of IL-4 (1997)

The onset of collagen-induced arthritis in DBA/1 mice is accompanied by a predominantly Th1 response, characterized by production of the proinflammatory cytokines IFN-gamma and TNF-alpha, and a predominance of IgG2a anti-collagen Abs. This study has primarily addressed the effects of continuous administration of exogenous IL-4, a Th2 cytokine, on collagen-induced arthritis in terms of time of onset, clinical symptoms, and histologic changes compared with those in untreated controls. The contributions of Th1 and Th2 cell responses were studied by examining anti-CII IgG subclasses, serum IgE levels, and cytokine production by synovial membrane and lymph node cell cultures. Continuous exposure to IL-4 for 28 days significantly delayed the onset of arthritis from 19 to 37 days and suppressed clinical symptoms. Arthritis occurred approximately 13 to 24 days after treatment ceased. Thereafter, the severity and duration of clinical symptoms were similar to those in control animals, although both joint damage and inflammation at the histologic and cellular levels were less severe than those in untreated controls. During IL-4 treatment, anti-collagen Ab levels were reduced (most significantly those of the IgG2a subclass), histology scores were lower, and the most striking effect was a 1000-fold decrease in TNF-alpha secretion by synovial cells. No significant differences in IgE levels were found between controls and IL-4-treated mice. These data suggest that the anti-inflammatory properties of IL-4 are mediated in part by down-regulation of Th1 responses rather than up-regulation of Th2 responses.
Estrogenic Activity of Isoflavone Derivatives Extracted and Prepared from Soybean Oil Meal (1953)

122MetricsTotal Downloads12Last 6 Months4Last 12 Months4Total Citations2Last 6 Months0Last 12 Months0View all metrics
Improved Mass Analysis of Oligoribonucleotides by <sup>13</sup>C, <sup>15</sup>N Double Depletion and Electrospray Ionization FT-ICR Mass Spectrometry (2004)

13C, 15N doubly depleted 32-ribonucleotide was synthesized enzymatically by in vitro transcription from nucleoside triphosphates isolated from E. coli grown in a minimal medium containing 12C, 14N-enriched glucose and ammonium sulfate. Following purification and desalting by reversed-phase HPLC, buffer exchange with Microcon YM-3, and ethanol precipitation, electrospray ionization Fourier transform ion cyclotron resonance mass spectra revealed greatly enhanced abundance of monoisotopic ions (by a factor of approximately 100) and a narrower isotopic distribution with higher signal-to-noise ratio. The abrupt onset and high magnitude of the monoisotopic species promise to facilitate accurate mass measurement of RNA's.
Different effects of a macrophage cytokine on proliferation in astrocytes and Schwann cells. (1994)

The proliferative response in vitro to a novel macrophage inflammatory protein (MIP) 1 alpha has been investigated in astrocytes and Schwann cells. MIP 1 alpha is growth-inhibitory in all cell systems investigated so far and we show here that this cytokine also inhibits the proliferation of astrocytes. This response is seen most clearly when MIP 1 alpha reduces the proliferative response of astrocytes to a potent mitogen. Elevation of intracellular cyclic AMP with forskolin enhances the effects of MIP 1 alpha. In contrast, we show that the proliferation of cultured Schwann cells is stimulated by MIP 1 alpha, and that stimulation is enhanced by simultaneous exposure to forskolin. The possible consequences of these differing responses are discussed in the context of the acute response to injury and potential for regeneration of the peripheral and central nervous systems.
Differentiation Among Metastatic Brain Tumors, Radiation Necroses, and Brain Abscesses Using Proton Magnetic Resonance Spectroscopy (2004)

Magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (MRS) were evaluated for differentiating metastatic brain tumors, radiation necroses, and brain abscesses. Twelve histologically verified lesions in 12 patients were studied using preoperative MRI and proton MRS. The signal intensities of four major metabolites, N-acetyl aspartate (NAA), choline-containing compounds (Cho), creatine and phosphocreatine (Cr), and lactate (Lac), were observed over the region of interest. Metastatic brain tumors showed a decrease in NAA/Cr and an increase in Cho/Cr ratios. Radiation necroses showed a decrease in NAA/Cr and no change in Cho/Cr ratios. Brain abscesses showed an increase in Lac/Cr ratio. Correlation with histopathologic findings showed that a high Cho signal was suggestive of a metastatic brain tumor. Lac signals were observed in brain abscesses, presumably reflecting the anerobic glycolysis of living cells. Although more cases and studies are necessary, metabolic information provided by proton MRS combined with MRI is useful for differentiating among metastatic brain tumors, radiation necroses, and brain abscesses.
Design of Optimal High-Rank Line-of-Sight MIMO Channels (2007)

This paper describes a technique for realizing a high-rank channel matrix in a line-of-sight (LOS) multiple-input multiple-output (MIMO) transmission scenario. This is beneficial for systems which are unable to make use of the originally derived MIMO gain given by independent and identically distributed (i.i.d.) flat Rayleigh fading subchannels. The technique is based on optimization of antenna placement in uniform linear arrays with respect to mutual information (MI). By introducing a new and more general 3-D geometrical model than that applied in earlier work, additional insight into the optimal design parameters is gained. We also perform a novel analysis of the sensitivity of the optimal design parameters, and derive analytical expressions for the eigenvalues of the pure LOS channel matrix which are valid also when allowing for non-optimal design. Furthermore, we investigate the approximations introduced in the derivations, in order to reveal when the results are applicable. The LOS matrix is employed in a Ricean fading channel model, and performance is evaluated with respect to the average MI and the MI cumulative distribution function. Our results show that even with some deviation from the optimal design, the LOS MEMO case outperforms the i.i.d. Rayleigh case in terms of MI.
Digital Chemical Vapor Deposition of SiO<sub>2</sub> Using a Repetitive Reaction of Triethylsilane/Hydrogen and Oxidation (1991)

The extraction reaction of hydrogen in triethylsilane (TES) with hydrogen radicals generated by a remote plasma of H 2 produces an organic Si film. Step coverage features of the film depend strongly on H 2 concentration in the TES+H 2 reaction system. A conformal profile has been achieved for 60% H 2 at 250°C as a result of the low-viscosity nature of the film which includes C x H y groups. With the aim of filling a deep trench with hlgh-quality SiO 2 film, digital chemical vapor deposition (CVD), which was carried out by repeating a cycle of the conformal deposition of the Si film and subsequent oxidation, was studied. The SiO 2 film which was deposited at 250°C and with an initial thickness per cycle of 5 Å at a 1 s oxygen pulse offered a low concentration of organic species, and thus a relatively low BHF etch rate.