gebhart/patrepeval huggingface dataset:
Validated multi‐drug determination using liquid chromatography with tandem mass spectrometry for the evaluation of a commercial drug disposal product (2016)

Currently, there are limited effective means of drug disposal for consumers, and this creates a gateway to illicit use and environmental contamination. Here, we evaluated the efficacy of a new drug disposal product, composed from a slurry of activated carbon, which claims to sequester up to 100% of a drug's active ingredient when the loading capacity is not exceeded, making it safe to dispose in landfill. High-performance liquid chromatography with tandem mass spectrometry was applied to quantify as many as 24 drugs (opiates, barbiturates, statins, amphetamine, and benzodiazepine drugs) in the residual solvent solution from the product. Calibration curves were established in the concentration ranges of 0.25-7.0 μg/mL and showed good linearity. The limits of detection varied from 0.001 to 0.02 μg/mL, depending on the drug. Accuracy ranged from 80 to 111% for quality control samples, with a few minor exceptions. Precision overall varied between 0.2 to 12.7%. In sample bottles tested, where active ingredient of the loaded drug was below the maximum sorption capacity stated on the label, 98 to >99.9% of the active ingredient was sequestered. Percent active ingredient adsorbed was slightly lower in bottles loaded in excess of label specifications.
Etranacogene dezaparvovec (AMT-061 phase 2b): normal/near normal FIX activity and bleed cessation in hemophilia B (2019)

Etranacogene dezaparvovec (AMT-061) is a recombinant AAV5 vector including a gene cassette containing the factor IX (FIX) Padua variant under the control of a liver-specific promoter. A phase 2b study was conducted to confirm that a single dose of 2 × 1013 genome copies per kilogram of etranacogene dezaparvovec will result in FIX activity ≥5% 6 weeks after dosing. Secondary end points included FIX activity at other time points, bleed frequency, FIX replacement, and safety. Etranacogene dezaparvovec was administered as a single IV infusion to 3 adults with severe to moderately severe hemophilia B. Before treatment, participants had low levels of preexisting neutralizing antibodies to AAV5. This article reports a planned 26-week interim assessment. At week 6, mean FIX activity was 31% (23.9%-37.8%), increasing to 47% (33.2%-57.0%) at 26 weeks, with 2 subjects exhibiting sustained activity >40%. Consistent with the FIX activity, etranacogene dezaparvovec was associated with a complete bleed cessation with no need for FIX replacement therapy up to 26 weeks. Etranacogene dezaparvovec was generally well tolerated. No clinically significant elevations in levels of liver enzymes or inflammatory markers were observed, and no use of corticosteroids related to treatment was required. In individuals with severe to moderately severe hemophilia B, etranacogene dezaparvovec resulted in clinically relevant increases in FIX activity, cessation of bleeds, and abrogation of the need for FIX replacement, despite the presence of preexisting anti-AAV5 neutralizing antibodies detected by using a highly sensitive luciferase assay. Consistency of results in the 3 participants supported an expanded evaluation of the safety/efficacy of etranacogene dezaparvovec in the HOPE-B (Health Outcomes With Padua Gene; Evaluation in Hemophilia-B) phase 3 trial. The current trial was registered at www.clinicaltrials.gov as #NCT03489291.
Electrical and Photoresponse Properties of Printed Thin-Film Transistors Based on Poly(9,9-dioctylfluorene-<i>co</i>-bithiophene) Sorted Large-Diameter Semiconducting Carbon Nanotubes (2013)

In this work, a simple and effective method has been developed to selectively separate large-diameter semiconducting-SWCNTs (sc-SWCNTs) from commercial arc discharge SWCNTs using (9,9-dioctylfluorene-co-bithiophene) (F8T2). The role of solvents in the separation and dispersion processes was studied. It has been proved that sc-SWCNTs mixed in arc discharge SWCNTs can be selectively sorted by F8T2 in toluene, xylene, or m-xylene with the aid of sonication and centrifugation, and the molecular dynamic simulation also agrees with the experiment results. The resulted sc-SWCNTs dispersion solution was used as a printable ink to print thin-film transistors (TFTs) via an aerosol jet printer. The printed TFTs showed good uniformity and electrical properties with on current up to 10–3 A, effective mobility up to 42.1 cm2 V–1 s–1 (±1.2 cm2 V–1 s–1), and on/off ratio of ∼107 after only four cycles of repeated printing. In addition, all of the printed devices exhibited rapid photocurrent response to light irradiation.
Dissolution (1993)

article Free Access Share on Dissolution: making paths vanish Authors: Neil V. Murray State University of New York at Albany, Albany, New York State University of New York at Albany, Albany, New YorkView Profile , Erik Rosenthal University of New Haven, West Haven, Connecticut University of New Haven, West Haven, ConnecticutView Profile Authors Info & Claims Journal of the ACMVolume 40Issue 3July 1993 pp 504–535https://doi.org/10.1145/174130.174135Online:01 July 1993Publication History 36citation569DownloadsMetricsTotal Citations36Total Downloads569Last 12 Months10Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Changing Epidemiology of Pseudomonas aeruginosa Infection in Danish Cystic Fibrosis Patients (1974–1995) (1999)

Recurrent and chronic lower airway infection with Pseudomonas aeruginosa (PA) is an important component of cystic fibrosis (CF) pulmonary disease. Different modes of treatment and control of CF patients have been introduced at the Copenhagen CF Centre over the past 20 years and have been associated with improved survival. Treatment consisted of: 1) elective antibiotics for 14 days every 3 months to patients with chronic PA infection (started in 1976), 2) cohort isolation to prevent cross-infection (patients with PA were separated from patients without PA, starting in 1981); and 3) early intensive treatment with inhaled colistin and oral ciprofloxacin from time of initial PA colonization (started in 1989). The aim of the present study was to evaluate the impact of each of these interventions on the changes in the epidemiology of PA. Based on monthly cultures of lower airway secretions in each CF patient seen during 1974–1995, significant changes in the incidence and prevalence of the PA infection were found. The monthly prevalence of chronic PA increased significantly (P < 0.0001) from below 40% before 1976 to above 60% in 1980, which was found to be due to cross-infection among the CF patients after introduction of elective antibiotic courses in 1976. To deal with this problem, cohort isolation was introduced in 1981, and since then the monthly point prevalence of chronic PA decreased slowly until 1989 (P < 0.0001), when early intensive treatment from initial PA colonization was introduced; this was associated with a further decrease in point prevalence to 45% in 1995 (P < 0.005). The annual incidence of chronic PA infection also decreased significantly (P < 0.01) from 16% to below 2% after introduction of cohort isolation and early intensive treatment from initial PA isolation. Furthermore, the time from acquisition of first PA to development of chronic PA infection increased significantly, from approximately 1 year to almost 4 years after introduction of cohort isolation (P < 0.0001). After introduction of early intensive treatment, the probability of still not having developed chronic PA infection 7 years after the first isolation of PA was above 80% (P < 0.0001). In conclusion, the introduction of cohort isolation and early intensive treatment following the initial isolation of PA resulted in a reduced incidence and prevalence of chronic PA infection. We are not aware of other studies showing a decreasing prevalence of chronic PA infection, as survival of CF patients has increased. Pediatr Pulmonol. 1999; 28:159–166. © 1999 Wiley-Liss, Inc.
System management software for virtual environments (2007)

Recently there has been an increased interest in the use of system-level virtualization using mature solutions such as Xen, QEMU, or VMWare. These virtualization platforms are being used in distributed and parallelenvironments including high performance computing. The use of virtual machines within such environments introduces newchallenges to system management. These include tedious tasks such as deploying para-virtualized host operating systems to support virtual machine execution or virtual overlay networks to connect these virtual machines. Additionally, there is the problem of machine definition and deployment,which is complicated by differentiation in the underlying virtualizationtechnology. This paper discusses tools for the deployment and management of both hostoperating systems and virtual machines in clusters. We begin with an overview of system-level virtualization and move on to a description of tools that we have developed to aid with these environments. These tools extend prior work in the area of cluster installation, configuration and management.
THE GENETICS OF A DIFFERENCE IN SKELETAL TYPE BETWEEN TWO INBRED STRAINS OF MICE (BalbC AND C57blk) (1951)

HE axial skeleton of the house mouse is composed in part of various T c o m b i n a t i o n s of 12, 13, or 14 thoracic (i.e., rib-bearing) and 5, 6, or 7 lumbar vertebrae. Only the 12/5 and 14/7 combinations have not been observed. Inbred strains of mice differ with respect to the incidence of the various skeletal types. The 13/6 type occurs in about 98 percent of the mice in the C57blk strain. The 14/5 type occurs in about 50 percent of the mice of the BalbC strain, the remaining 50 percent being 13/6, 14/6, and some other types.
Rayleigh Laser Guide Star Systems: Application to UnISIS (2002)

Laser guide stars created by Rayleigh scattering provide a reasonable means to monitor atmospheric wavefront distortions for real-time correction by adaptive optics systems. Because of the $λ^{-4}$ wavelength dependence of Rayleigh scattering, short wavelength lasers are a logical first choice for astronomical laser guide star systems, and in this paper we describe the results from a sustained experimental effort to integrated into an adaptive optics system a 351 nm Rayleigh laser guide star created at an altitude of 20 km (above MSL) at the Mt. Wilson 2.5-m telescope. In addition to providing obvious scientific benefits, the 351 nm laser guide star projected by UnISIS is "Stealth qualified: in terms of the FAA and airplane avoidance. Due to the excellent return signal at the wavefront sensor, there is no doubt that future applications will be found for short-wavelength Rayleigh scattered laser guide stars.
Rural School: A Face-Lifting (1950)

(1950). Rural School: A Face-Lifting. The Clearing House: A Journal of Educational Strategies, Issues and Ideas: Vol. 24, No. 8, pp. 495-496.
Ablative optical recording using organic dye-in-polymer films (1980)

Ablative optical recording using dissolved dyes in polymer films has been investigated. Polyester yellow dissolved in poly(vinyl acetate) was used as a model to study the potential for high-sensitivity, high-density optical storage applications. With 20% dye loading, a 59-nm film was more sensitive at 457 nm than a 15-nm Te monolayer, and marks down to 0.5 μm were recorded. The signal contrast (Rf−Ri)/(Rf+Ri) was approximately 0.68 for marks ablated with high-energy laser pulses. The morphology of the marks shows a clean removal of recording material. Suitable polymeric overcoatings, used to simulate second-surface recording situations, had little effect on the results.
Hepatic vein arrival time as assessed by contrast-enhanced ultrasonography is useful for the assessment of portal hypertension in compensated cirrhosis (2012)

The measurement of the hepatic venous pressure gradient (HVPG) for the estimation of portal hypertension (PH) in cirrhosis has some limitations, including its invasiveness. Hepatic vein arrival time (HVAT), as assessed by microbubble contrast-enhanced ultrasonography (CEUS), is negatively correlated with the histological grade of liver fibrosis because of the associated hemodynamic abnormalities. Anatomical and pathophysiological changes in liver microcirculation are the initial events leading to PH. However, the direct relationship between HVAT and PH has not been evaluated. The present study measured both HVPG and HVAT in 71 consecutive patients with compensated cirrhosis and analyzed the relationship between the two parameters (i.e., the derivation set). Results were validated in 35 compensated patients with cirrhosis at another medical center (i.e., the validation set). The derivation set had HVPG and HVAT values of 11.4 ± 5.0 mmHg (mean ± standard deviation; range, 2-23) and 14.1 ± 3.4 seconds (range, 8.4-24.2), respectively; there was a statistically significant negative correlation between HVPG and HVAT (r(2) = 0.545; P < 0.001). The area under the receiver operating characteristic curve (AUROC) was 0.973 for clinically significant PH (CSPH; HVPG, ≥ 10 mmHg), and the sensitivity, specificity, positive predictive value, negative predictive value, and positive and negative likelihood ratios for CSPH for an HVAT cut-off value of 14 seconds were 92.7%, 86.7%, 90.5%, 89.7%, 6.95, and 0.08, respectively. In addition, a shorter HVAT was associated with worse Child-Pugh score (P < 0.001) and esophageal varices (P = 0.018). In the validation set, there was also a significant negative correlation between HVAT and HVPG (r(2) = 0.538; P < 0.001), and AUROC = 0.953 for CSPH. HVAT was significantly correlated with PH. These results indicate that measuring HVAT is useful for the noninvasive prediction of CSPH in patients with compensated cirrhosis.
A simple, flexible and efficient PCR-fusion/Gateway cloning procedure for gene fusion, site-directed mutagenesis, short sequence insertion and domain deletions and swaps (2009)

The PCR-fusion/Gateway cloning procedure described provides an elegant, simple and efficient solution for a wide range of diverse and complicated cloning tasks. Through streamlined cloning of sets of gene fusions and modification variants into binary vectors for systematic functional studies of gene families, our method allows for efficient utilization of the growing sequence and expression data.
Amplification of Cosmid and Plasmid Libraries (1996)

The purpose of amplification is to provide a reagent library that can be used many times. In this protocol, bacteria containing the recombinant clones are grown on agar plates, washed off the plates, and stored in glycerol. An amplified cosmid or plasmid library will contain one library's equivalence in 10 to 100 microl. By producing 100 microl of such a library frozen in 100 1-ml tubes, over 1000 platings can be expected.
Immunoelectron Microscopic Localization of Cholesterol Using Biotinylated and Non-cytolytic Perfringolysin O (2002)

We used a proteolytically modified and biotinylated derivative of the cholesterol-binding Theta-toxin (perfringolysin O) to localize cholesterol-rich membranes in cryosections of cultured human lymphoblastoid cells (RN) by electron microscopy. We developed a fixation and immunolabeling procedure to improve the preservation of membranes and minimize the extraction and dislocalization of cholesterol on thin sections. We also labeled the surface of living cells and applied high-pressure freezing and subsequent fixation of cryosections during thawing. Cholesterol labeling was found at the plasma membrane, with strongest labeling on filopodium-like processes. Strong labeling was also associated with internal vesicles of multivesicular bodies (MVBs) and similar vesicles at the cell surface after secretion (exosomes). Tubulovesicular elements in close vicinity of endosomes and the Golgi complex were often positive as well, but the surrounding membrane of MVBs and the Golgi cisternae appeared mostly negative. Treatment of cells with methyl-beta-cyclodextrin completely abolished the labeling for cholesterol. Our results show that the Theta-toxin derivative, when used in combination with improved fixation and high-pressure freezing, represents a useful tool for the localization of membrane cholesterol in ultrathin cryosections.
Carbon/poly {pyrrole-[(C<sub>5</sub>Me<sub>5</sub>)Rh<sup>III</sup>(bpy)Cl]<sup>+</sup>} modified electrodes; a molecularly-based material for hydrogen evolution (bpy = 2,2′-bipyridine) (1989)

A rhodium(III) complex containing a 2,2′-bipyridine ligand substituted with pyrrole groups has been anodically electropolymerized on either a Pt or a C electrode; the polymer attached to C acts as an efficient molecularly-based cathode material for hydrogen evolution in aqueous solution (pH 1).
Effet de l´amlimentation azotée sur le comportement et la typicité des vins de l´Arvine (2014)

L’Arvine est un ancien cepage autochtone du canton du Valais (Suisse), atteste des le XVIIe siecle (Vouillamoz et Moriondo 2011). Longtemps cultivee a petite echelle, l’Arvine a connu une forte progression dans le vignoble valaisan ces vingt dernieres annees (fig.1), liee a la revalorisation des cepages autochtones de qualite en Valais et a la personnalite de ses vins aux aromes complexes, fruites et floraux (Dupraz et Spring 2010). Cette typicite aromatique est due a des composes soufres de la famille des thiols (comme pour le Sauvignon): chez l’Arvine, il s’agit principalement du 3-mercapto-hexanol (Fretz et al. 2005), dont les aromes evoquent le pamplemousse, le citron, la compote de rhubarbe et les fruits exotiques et dont le seuil de perception avoiEffet de l’alimentation azotee sur le comportement et la typicite des vins de l’Arvine
Cleaning Trajectory Evaluation of a Wall Cleaning Robot Based on Synthesis Standards (2006)

Path planning is a fundamental issue in mobile robotics. Even if the path planning methods for mobile ground-robots and those of wall-cleaning robots have a lot in common, the latter still feature some particular characteristics. In this paper, a new approach to path planning for wall-cleaning robots is presented based on an evaluation by the synthesis of standards. Considering the characteristics of the workspace, a mathematic model is proposed to describe the features of the work target. Cleaning trajectory is determined and evaluated by the synthesis of movement security, cleaning efficiency and the percentage of cleaning coverage. This paper presents the results of experiments on the sky cleaner robot for glass-wall cleaning, which demonstrate the efficiency and feasibility of the new approach
Tuning of Material and Electrical Properties of Strontium Titanates using Process Chemistry and Composition (2008)

In this work, we study the compatibility of a highly volatile strontium precursor, HyperSr, which has a low melting point, good thermal stability and good reactivity, with various Ti precursors for atomic layer deposition (ALD) of strontium titanates (STO). Novel Ti precursors studied for STO deposition include PrimeTi & StarTi. We will then discuss the interesting trends in material properties observed in STO films deposited with various compositions. X-ray photoelectron spectroscopic analysis of ALD SrO films showed the presence of carbonate groups in the film. There is the potential that this carbonate species is inherent to the ALD process; however, it has been reported that SrCO3 forms when SrO films are exposed to atmospheric CO2. To isolate the effects of atmospheric exposure on the carbonate formation in the film, a TiO2 capping layer is used on the surface of ALD SrO films and the resulting film structures are analyzed.
Flow cytometric reticulocyte quantification using thiazole orange provides clinically useful reticulocyte maturity index. (1989)

Flow cytometric reticulocyte quantification with thiazole orange has been reported to be of potential utility in a clinical hematology laboratory. We have instituted this technique into routine clinical testing for 18 months and we describe this experience. Flow cytometric analysis provided not only reproducible, cost-effective reticulocyte quantification, but a quantitative reticulocyte maturity index proportional to the amount of RNA in the reticulocytes. The reticulocyte maturity index measurement represents an independent parameter of erythropoiesis, which provided clinically valuable information regarding bone marrow engraftment in patients following autologous bone marrow transplantation. The findings of this study demonstrate the clinical utility of thiazole orange reticulocyte analysis and indicate the diagnostic importance of the reticulocyte maturity index measurement in the evaluation of erythropoietic activity.
Characterization of the NADH lifetime at different cell densities in a culture (2008)

One of the major intrinsic fluorophores, reduced nicotinamide dinucleotide (NADH) is as sensitive non-invasive indicator of the cellular energy metabolism, whereas measurement of its fluorescence lifetime has been demonstrated to derive more information from the cells, than its spectrum, providing with the information on free and enzyme-bound states dynamics of the NADH as well as its environment. This attractiveness of NADH as a non-invasive indicator served as a basis for the rapid increase in it studies, which resulted in a number of diagnostic methods for a range of pathological conditions, utilizing NADH. Given this growing importance of NADH thorough characterization of its lifetime dynamics is of high importance. We have conducted a series of NADH lifetime measurements at different cell density in the early logarithmic growth phase. The results has shown that the decrease in both short and long lifetime compounds is the earlier event cell culture growth, than the changes in NADH lifetime components preexponential factors ratio.
BGP Monitoring Protocol (BMP) (2016)

This document defines the BGP Monitoring Protocol (BMP), which can be used to monitor BGP sessions. BMP is intended to provide a convenient interface for obtaining route views. Prior to the introduction of BMP, screen scraping was the most commonly used approach to obtaining such views. The design goals are to keep BMP simple, useful, easily implemented, and minimally service affecting. BMP is not suitable for use as a routing protocol.
On-response deficit in the electroretinogram of the cone system in X-linked retinoschisis. (2001)

The reduced b-wave to d-wave ratio of the ERG of the cone system in these patients with XLRS is consistent with a relative dysfunction of the cone ON bipolar cell pathway in this disorder. The results show further that sawtooth flicker is a promising stimulus for eliciting well-defined ERG waveforms that can provide a quantitative assessment of the properties of ON and OFF responses in retinal disease.