gebhart/patrepeval huggingface dataset:
Radiation hard LOCOS field oxide (1994)

It is known that radiation hard field oxides (FOX) can be produced by combination of a thin thermal oxide and a thick P- or As-doped deposited oxide. The doping atoms serve as recombination centers and electron traps for radiation induced charges. This results in a distinctly lower oxide charge at the Si/SiO/sub 2/ interface compared to conventional thermal oxides and, therefore, higher radiation hardness. The radiation resistance of thermally grown FOX for LOCOS isolation cannot be improved much by changes in oxidation parameters. The newly developed radiation hard FOX is produced by local oxidation of P-doped poly-Si. This method preserves the advantages of the LOCOS technology. To distinguish this process from the regular LOCOS process we termed it LOPOX (Local Polysilicon Oxidation). Even with low doping concentrations radiation hardness is improved considerably compared to conventional thermal oxides.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Early Experience and Initial Outcomes With Patient-Specific Spine Rods for Adult Spinal Deformity (2016)

The objectives of this study were to describe the process of preoperative planning and using patient-specific rods. This retrospective case series involved 18 patients with adult spinal deformity who were treated with posterior instrumentation and spine fusion, with lumbar or thoracic osteotomies, using patient-specific rods. Data extracted included demographic/surgical variables and preoperative, predicted (surgical plan), and postoperative spinopelvic parameters. The outcome analysis involved assessment of preoperative, planned, and postoperative variables. Treatment effect evaluation involved assessing differences between preoperative and postoperative values and correspondence between planned and achieved results. Surgery using preoperative planned patient-specific rods led to excellent adult spinal deformity correction and spinopelvic alignment.
Design of a semi-passive heavy-duty mobile robotic system for automated assembly inside an aircraft body (2008)

We present an initial design of a mobile robotic system for automated assembly inside an aircraft body. This system allows for the positioning control of a heavy duty end effector that is working on the far side of a thin wall at any orientation. It utilizes electromagnets to hold the end effector against the wall, as well as linear motor type actuation for locomotion. Initial testing on a prototype verifies the effectiveness of some of the chosen design parameters.
Intestinal Lipid Handling (2014)

According to the present data, the small intestine may be classified as an insulin-sensitive tissue. Dysregulation of intestinal insulin signaling, possibly triggered by oxidative stress and inflammation, was associated with exaggerated lipogenesis and lipoprotein synthesis, which may represent a key mechanism for atherogenic dyslipidemia in patients with metabolic syndrome.
Detection of endonuclease activity and several features of chromatin autolysis in brain cell nuclei (1979)

The presence of Ca2+, Mg2+-dependent endonuclease activity in isolated brain cell nuclei was demonstrated and a comparison of some peculiarities of chromatin autolysis in rat brain and liver cell nuclei was carried out. Endogenous brain nuclease hydrolyzes chromatin into its structural subunits; its specific activity is 10,5 times as low as compared to the endogenous nuclease activity in rat liver nuclei. The dependency of the chromatin autolysis rate on pH and ionic composition of the incubation medium in isolated rate brain and liver nuclei appeared to be the same. The presence of Mn2+ changed the autolysis nature both in brain and in liver cell nuclei, the relative (as compared to Mg2+-dependent) Mn2+-dependent activity being higher in the brain cell nuclei. Possible differences of brain and liver chromatin structure (e. g. the presence of regions free of nucleosomic organization in brain chromatin) are assumed.
Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome (2004)

The amount of research into endocrine disruption has exploded over the past decade and a re-evaluation of the state of research in this area is timely. There are debates about whether human male reproductive health is really declining and whether endocrine disrupting chemicals play any role in the perceived decline. Most data currently conclude that there are wide geographical variations in semen quality and in the incidence of testicular cancer, cryptorchidism and hypospadias. This review aims to give a brief overview of the issues surrounding the perceived decline in human male reproductive health and the importance of the hormonal environment for the development of the testis and reproductive tract. The consequences for the male reproductive tract of abnormal androgen levels or action are discussed with reference to environmental anti-androgenic compounds. The in vivo data on several anti-androgenic compounds that have been administered to pregnant rodents during the period of male reproductive tract development are assessed with attention to the effects on the male offspring. Finally, the data on in utero phthalate administration are discussed in detail to illustrate the similarities between the effects of some phthalate esters and the human male reproductive tract disorders which comprise testicular dysgenesis syndrome (TDS).
Elevated Glycosaminoglycans and Chondroitin 4-Sulfate, and Other Properties of Contracted Human Prosthesis Capsules (1981)

Replacement of collapsed silicone rubber breast prostheses enclosed by otherwise asymptomatic connective tissue capsules provided an opportunity to take samples of normal capsules for comparison with samples of contracted capsules obtained during surgical revision. The contracted capsules contained more glycosaminoglycans, as indicated by uronic acid measurements and electrophoresis. The glycosaminoglycan data confirms the hypothesis that capsule contracture and hypertrophic scar formation are closely related phenomena.
Scanning tunneling microscopy on epitaxial bilayer graphene on ruthenium (0001) (2009)

The atomic structure of epitaxial single and bilayer graphene on Ru(0001) was studied by scanning tunneling microscopy (STM). High-resolution imaging of the surface of single layer graphene shows a moiré with pronounced buckling and broken A/B carbon sublayer symmetry due to a strong interaction with the metal substrate. The top sheet of bilayer graphene is largely unperturbed by residual interactions with the substrate. Screened from the metal substrate, it shows the hallmarks of freestanding monolayer graphene: a honeycomb structure with equivalent carbon sublattices imaged in STM and a linear dispersion of π-bands near the Dirac point.
Support for the multigenic hypothesis of amyloidosis: The binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity <i>in</i> <i>vitro</i> (2001)

The amyloidoses are a large group of protein misfolding diseases. Genetic and biochemical evidence support the hypothesis that amyloid formation from wild-type or 1 of 80 sequence variants of transthyretin causes the human amyloid diseases senile systemic amyloidosis or familial amyloid polyneuropathy, respectively. The late onset and variable penetrance of these diseases has led to their designation as multigenic--implying that the expression levels and alleles of multiple gene products influence the course of pathology. Here we show that the binding stoichiometry of three interacting molecules, retinol-binding protein, vitamin A, and L-thyroxine, notably influenced transthyretin amyloidogenicity in vitro. At least 70 genes control retinol-binding protein, vitamin A, and L-thyroxine levels in plasma and have the potential to modulate the course of senile systemic amyloidosis or familial amyloid polyneuropathy.
Efficient Mechanoluminescent Elastomers for Dual‐Responsive Anticounterfeiting Device and Stretching/Strain Sensor with Multimode Sensibility (2018)

Abstract In this work, an environmentally friendly and novel oxide‐based mechanoluminescent material, Sr 3 Al 2 O 6 : Eu 3+ , which can serve as the alternative for the widely used but environmentally hazardous transition metal–doped sulfides is reported. This oxide could exhibit highly efficient photoluminescence, but even more efficient mechanoluminescence as embedded into polydimethylsiloxane matrix under mechanical stimulation. The emitting color of the resultant Sr 3 Al 2 O 6 : Eu 3+ /polydimethylsiloxane elastomer composites could be further manipulated by adjusting the synthesis atmosphere of the Sr 3 Al 2 O 6 : Eu 3+ based on its unique self‐reduction characteristic. Moreover, by combining the wavelength selectivity of photoluminescence and dynamic stress response of mechanoluminescence, Sr 3 Al 2 O 6 : Eu 3+ enables the design of two types of intriguing devices. They are a dual‐responsive anticounterfeiting flexible device activated by either photons or mechanics, and a comprehensive stretching/strain sensor capable of sensing both strain level and stretching states. In comparison to the conventional luminescent materials, with a rare combination of efficient photoluminescence, highly sensitive mechanoluminescence, and facile color tunability, Sr 3 Al 2 O 6 : Eu 3+ is much more versatile and ideal for various advanced applications.
Effects of metabolic acidosis on viability of cells exposed to anoxia (1985)

The effects of metabolic acidosis were examined in isolated rat hepatocytes under substrate-free oxygenated or anoxic conditions. Lowering extracellular pH to 6.6 under aerobic conditions had no deleterious effects on the cells as determined by trypan blue exclusion, lactate dehydrogenase (LDH) release, cellular K+ and Ca2+ content, and ability to increase ATP levels after nutrients and adenosine were added to media. Cytosolic pH was measured in aerobic cells at varying extracellular pH using 6-carboxyfluorescein. By using values for cytosolic pH obtained in this manner together with 5,5-dimethyl[2-14C]oxazolidine-2,4-dione (DMO) distribution data, a method was derived for determining intramitochondrial pH. The pH gradient across the mitochondrial membrane was found not to change with a decrease in extracellular pH from 7.4 to 6.9. At pH 6.9 hepatocytes were protected against anoxic injury as compared with cells incubated at pH 7.5 or 6.6. This protection was manifested by a decrease in vital dye uptake and LDH release, maintenance of higher cellular K+ content, less stimulation of respiration with succinate, improved recovery of ATP levels after return to an oxygenated nutrient environment, and maintenance of normal cellular Ca2+ content after reoxygenation. Recovery of cellular ATP content was independent of ATP levels, total adenine nucleotide pool, and energy charge ratio at the end of the anoxic period. Measurement of cytoplasmic pH in anaerobic cells by [14C]DMO distribution showed progressive cellular acidification with lowering of extracellular pH. The protective effects observed at pH 6.9 are not unique to hepatocytes since isolated renal cortical tubules exposed to anoxia have improved ATP levels on reoxygenation at this pH when compared with tubules incubated at pH 7.5.
Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa (1991)

Exoenzyme S is an ADP-ribosyltransferase enzyme distinct from exotoxin A that is synthesized and secreted by Pseudomonas aeruginosa. Yields of exoenzyme S are variable and depend on strain and growth conditions. Since certain medium additives are required for exoenzyme S production, its regulation may be influenced by environmental stimuli. In this study, we have cloned a region that complements the exoenzyme S-deficient phenotype of strain 388 exs1::Tn1, a chromosomal Tn1 insertional mutation. A large clone (28 kb) was shown to restore both synthesis and secretory functions to the mutant strain. Subcloning and Tn501 mutagenesis experiments localized the region required for exoenzyme S synthesis to a 3.2-kb fragment. Nucleotide sequence analysis demonstrated several open reading frames. Comparison of the N-terminal amino acid sequence of purified exoenzyme S with predicted amino acid sequences of all open reading frames indicated that the structural gene was not encoded within the sequenced region. Homology studies suggested that the region encoded three regulatory genes, exsC, exsB, and exsA. ExsA was homologous to the AraC family of transcriptional activator proteins, with extensive homology being found with one member of this family, VirF of Yersinia enterocolitica. VirF and ExsA both contain carboxy-terminal domains with the helix-turn-helix motif of DNA-binding proteins. The ExsA gene product appeared to be required for induction of exoenzyme S synthesis above a low basal level. Expression of ExsA was demonstrated by cloning the region under the control of the T7 promoter. Gene replacement experiments suggested that the expression of ExsC affects the final yield of exoenzyme S.
Gaussian ringlet intensity distribution (GRID) features for rotation-invariant object detection in wide area motion imagery (2014)

Most detection algorithms are established by using well defined features. Since wide area imagery is low resolution and has features that are not well defined, a local intensity distribution based methodology seems a likely candidate. We propose a new methodology, Gaussian Ringlet Intensity Distribution (GRID), which is a derivative of the ring-partitioned histograms for local intensity distribution based object tracking in low-resolution environments, which deals with the issue of rotation invariance. We observed that the proposed algorithm produces the highest accuracy among other state of the art methodologies and provides robust features for rotationally invariant detection and tracking in wide area motion imagery.
Autonomous Inventory Monitoring through Multi-Modal Sensing (AIM3S) for Cashier-Less Stores (2019)

Auto-checkout technology could revolutionize physical retail by bringing down operating costs and enabling automated stores. The first step towards fully autonomous stores is automated live inventory monitoring. Existing automated approaches tend to focus on vision only and are cost prohibitive, slow, or inaccurate for practical real-world applications. To overcome these challenges we propose a novel sensor fusion framework through cameras, weight sensors and prior knowledge of item arrangement. Namely we focus on the tasks of event detection (i.e. when did customers pick up or return an item?), and robust item classification (i.e. what product was it?). In this demo we show the system can be implemented to accurately predict inventory in real-time.
Electrical structure and E-fields in the high-latitude mesosphere (1995)

A description of the electric structure as observed during a rocket sounding noctilucent cloud (NLC) observation program in the summer of 1991, is presented. Both NLC and polar mesosphere summer echo (PMSE) conditions were determined. The observable effects on ions and electrons were measured in the NLC and PMSE regions and associated electric field (E-fields) measurements indicated small alternating current vertical fields. The following findings are reported: small and large scale electron density structure is noticeable in the NLC regions; above 82 km, the occurrence of very low-mobility positive ions directly demonstrates the existence of charged aerosols, and small alternating current vertical electric fields were observed in the NLC and PMSE region.
Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded libraries (2016)

Achieving sufficient enrichment of ligands from DNA-encoded libraries for detection can be difficult, particularly for low affinity ligands within highly complex libraries. To address this challenge, we present an approach for crosslinking DNA-linked ligands to target proteins using electrophilic or photoreactive groups. The approach involves the teathering of a ssDNA oligonucleotide to a DNA-encoded molecule to enable attachment of a reactive group post-synthetically via DNA hybridization. Crosslinking traps ligand-protein complexes while in solution and allows for stringent washing conditions to be applied in the subsequent purification. Five reactive groups (tosyl, NHS ester, sulfonyl fluoride, phenyl azide, and diazirine) were tested for crosslinking efficiency and specificity with three DNA-linked ligands to their target proteins. In a model selection, crosslinking resulted in improved enrichment of both high and a low affinity ligands in comparison to a selection with a solid-phase immobilized protein.
GaAs power FET's having the gate recess narrower than the gate (1986)

GaAs power FET's have been fabricated with the gate recess narrower than the gate. The fabrication process for this new channel structure is described and microwave performance is presented. The best device had greater than 1 W output power per millimeter gate width at 10 GHz.
Development of Array-based Technology for Detection of HAV Using Gold-DNA Probes (2005)

A sensitive method for detection of Hepatitis A virus (HAV) by utilizing gold-DNA probe on an array was developed. Amino-modified oligodeoxynucleotides at the 5' position were arrayed on an activated glass surface to function as capture probes. Sandwich hybridization occurred among capture probes, the HAV amplicon, and gold nanoparticlesupported oligonucleotide probes. After a silver enhancement step, signals were detected by a standard flatbed scanner or just by naked eyes. As little as 100 fM of HAV amplicon could be detected on the array. Therefore, the array technology is an alternative to be applied in detection of HAV due to its low-cost and high-sensitivity.
Generating Synthetic Irises by Feature Agglomeration (2006)

We propose a technique to create digital renditions of iris images that can be used to evaluate the performance of iris recognition algorithms. The proposed scheme is implemented in two stages. In the first stage, a Markov random field model is used to generate a background texture representing the global iris appearance. In the next stage a variety of iris features, viz., radial and concentric furrows, collarette and crypts, are generated and embedded in the texture field. The iris images synthesized in this manner are observed to bear close resemblance to real irises. Experiments confirm the potential of this scheme to generate a database of synthetic irises that can be used to evaluate iris recognition algorithms.
Two-Phase Image Encryption Scheme Based on FFCT and Fractals (2017)

This paper blends the ideas from recent researches into a simple, yet efficient image encryption scheme for colored images. It is based on the finite field cosine transform (FFCT) and symmetric-key cryptography. The FFCT is used to scramble the image yielding an image with a uniform histogram. The FFCT has been chosen as it works with integers modulo <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>p</mml:mi></mml:mrow></mml:math> and hence avoids numerical inaccuracies inherent to other transforms. Fractals are used as a source of randomness to generate a one-time-pad keystream to be employed in enciphering step. The fractal images are scanned in zigzag manner to ensure decorrelation of adjacent pixels values in order to guarantee a strong key. The performance of the proposed algorithm is evaluated using standard statistical analysis techniques. Moreover, sensitivity analysis techniques such as resistance to differential attacks measures, mean square error, and one bit change in system key have been investigated. Furthermore, security of the proposed scheme against classical cryptographic attacks has been analyzed. The obtained results show great potential of the proposed scheme and competitiveness with other schemes in literature. Additionally, the algorithm lends itself to parallel processing adding to its computational efficiency.
X-ray Analysis of the NMC-A β-Lactamase at 1.64-Å Resolution, a Class A Carbapenemase with Broad Substrate Specificity (1998)

The treatment of infectious diseases by penicillin and cephalosporin antibiotics is continuously challenged by the emergence and the dissemination of the numerous TEM and SHV mutant beta-lactamases with extended substrate profiles. These class A beta-lactamases nevertheless remain inefficient against carbapenems, the most effective antibiotics against clinically relevant pathogens. A new member of this enzyme class, NMC-A, was recently reported to hydrolyze at high rates, and hence destroy, all known beta-lactam antibiotics, including carbapenems and cephamycins. The crystal structure of NMC-A was solved to 1.64-A resolution, and reveals modifications in the topology of the substrate-binding site. While preserving the geometry of the essential catalytic residues, the active site of the enzyme presents a disulfide bridge between residues 69 and 238, and certain other structural differences compared with the other beta-lactamases. These unusual features in class A beta-lactamases involve amino acids that participate in enzyme-substrate interactions, which suggested that these structural factors should be related to the very broad substrate specificity of this enzyme. The comparison of the NMC-A structure with those of other class A enzymes and enzyme-ligand complexes, indicated that the position of Asn-132 in NMC-A provides critical additional space in the region of the protein where the poorer substrates for class A beta-lactamases, such as cephamycins and carbapenems, need to be accommodated.
Reactivity of the Iron Porphyrin Fe(TPP)(NO) with Excess NO. Formation of Fe(TPP)(NO)(NO<sub>2</sub>) Occurs via Reaction with Trace NO<sub>2</sub> (2000)

Fe(TPP)(NO) (TPP = tetraphenylporphyrinato dianion) does not react observably with excess NO in organic solvents at ambient pressure and temperature; however, adventitious NO2 rapidly leads to the nitrosyl nitro product Fe(TPP)(NO)(NO2), which is labile toward loss of NO.
Cardiorespiratory motion‐compensated micro‐CT image reconstruction using an artifact model‐based motion estimation (2015)

Using sequential double gating combined with artifact model-based motion estimation allows to accurately estimate respiratory and cardiac motion from highly undersampled data. No sensitivity to streaking artifacts introduced by sparse angular sampling has been observed for the investigated dose levels. The motion-compensated image reconstruction was able to correct for both, respiratory and cardiac motion, by applying the estimated motion vector fields. The administered dose per animal can thus be reduced for 5D imaging allowing for longitudinal studies at the highest image quality.
Hierarchical Sensor Fusion for Building an Occupancy Grid Map using Active Sensor Modules (2006)

An algorithm for three level hierarchical sensor fusions has been proposed and applied to environment map building with enhanced accuracy and efficiency. The algorithm was realized through the two new types of sensor module, which are composed a halogen lamp based active vision sensor and a semicircular ultrasonic (US) and infrared (IR) sensor system. In the first level fusion, the US and IR sensor information is utilized in terms of geometric characteristics of the sensor location. In the second level fusion, the output from the US and IR sensors are combined with the sheet of halogen light through a proposed rule base. In the third level fusion, local maps from the first and second level fusion are updated in probabilistic way for a very accurate environment local map. A practical implementation has been carried out to demonstrate the efficiency and accuracy of the proposed hierarchical sensor fusion algorithm in environment map building