gebhart/patrepeval huggingface dataset:
Structure–Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors (2016)

The two isoforms of sphingosine kinase (SphK1 and SphK2) are the only enzymes that phosphorylate sphingosine to sphingosine-1-phosphate (S1P), which is a pleiotropic lipid mediator involved in a broad range of cellular processes including migration, proliferation, and inflammation. SphKs are targets for various diseases such as cancer, fibrosis, and Alzheimer's and sickle cell disease. Herein, we disclose the structure-activity profile of naphthalene-containing SphK inhibitors and molecular modeling studies that reveal a key molecular switch that controls SphK selectivity.
Trunk Strength Testing with Iso-Machines (1993)

This review of the scientific literature on isokinetic and isoinertial testing of dynamic trunk strength related to low back pain using "iso-machines" identified 108 items published in the past decade. There was inadequate scientific evidence to support the use of iso-machines in preemployment screening, routine clinical assessment or medico-legal evaluation.
A Generalized Network Formulation of the Pairwise Comparison Consensus Ranking Model (1986)

One of the best known and most widely referenced models for representing ordinal preferences is that due to Kemeny and Snell (Kemeny, J. G., L. J. Snell. 1962. Preference ranking: an axiomatic approach. Mathematical Models in the Social Sciences. Glnn, New York, 9–23.). This model is designed to accommodate pairwise comparison data with an l 1 norm used to measure voter disagreement. While this model possesses many of the necessary properties for a social choice function, solution procedures developed to date have been capable of handling only small problems due to the difficulty of modelling the transitivity requirements of an optimal consensus ranking. This paper shows how the consensus formation problem for strict linear orderings can be modelled as a generalized network. Since efficient computer codes already exist for handling this special structure, this approach will permit the solution of much larger problems than has been the case previously.
LUTEINIZING HORMONE (LH) AND PROGESTERONE IN PLASMA AND LH AND OESTROGENS IN URINE DURING 42 NORMAL MENSTRUAL CYCLES (1971)

ABSTRACT The plasma levels of luteinizing hormone (LH) and progesterone and the urinary excretion of LH and oestrogens were measured during the normal menstrual cycle of 22 young and healthy women. A total of 42 cycles were investigated. The urinary excretion of total oestrogens increased during several days before the rise of LH in the urine. The day of maximum excretion of LH and total oestrogens coincided during the midcycle period. The mid-cyclic rise in LH was found to occur on the same day in the plasma and urine and the days of maximum values coincided in 11 out of 16 cycles. In 5 cycles the maximum level was reached one day later in the urine. The plasma levels of progesterone started to increase during the LH and oestrogen peaks. The days for maximum levels of progesterone coincided with the second peak of urinary oestrogens. The levels of progesterone in the plasma reached values above 10 ng per ml in all normal cycles. The plasma levels of progesterone were below 1 ng per ml plasma when menstrual bleeding started. The length of the luteal phase was 14.4 ± 1.1 (s) days. The sum of daily urinary excretion of total oestrogens and the sum of the daily plasma progesterone levels varied within 15 per cent of the mean in five out of six women studied during more than two cycles. The variation in values for the sums of daily oestrogen excretion and plasma progesterone levels was considerably larger between menstrual cycles of different women than between menstrual cycles of the same woman.
A review on various multipliers designs in VLSI (2015)

In this paper we are going to study Array multiplier, Wallace multiplier, Bypassing multiplier, Modified Booth multiplier, Vedic multiplier and Booth recorded Wallace tree multiplier which have been proposed by different researchers. When the study of the various multipliers have been performed, Array multiplier is found to have the largest delay and large power consumption while Booth encoded Wallace tree multiplier has the least delay though it also have a large area. We also realized that, with proper optimization the performance of the multipliers can be increased significantly, irrespective of the type. Temporal tilling method optimized array multiplier delay and power dissipation is found to increase by 50% and 30% respectively while using the partially guarded technique power consumption is reduced by 10-44% with 30-36% less area overhead. Booth recorded Wallace tree multiplier is found to be 67% faster than the Wallace tree multiplier, 53% faster than the Vedic multiplier, 22% faster than the radix 8 booth multipliers. We also study various optimization techniques for Wallace multiplier, bypassing multiplier, modified booth multiplier and Vedic multiplier.
Exchange Coupling in NiFe/Ni Bilayer Fabricated By Electrodeposition (2011)

Bilayers of soft NiFe (150 nm-420 nm) on hard Ni (150 nm) were prepared by electrodeposition. The process of magnetization reversal in the NiFe/Ni bilayers was then investigated. The hysteresis loop generated by a magnetization reversal of soft NiFe under a positive saturation state of a hard Ni layer shows a shift along the negative field axis, which is clear evidence for the exchange spring effect in the NiFe/Ni bilayers. The dependence of the coercive field <TEX>$H_c$</TEX> and exchange bias field Hex on the thickness of the NiFe layer was also investigated. As the NiFe thickness increases from 150 nm to 420 nm, both <TEX>$H_c$</TEX> and <TEX>$H_{ex}$</TEX> decrease rapidly from <TEX>$H_c$</TEX>= 51.7 Oe and <TEX>$H_{ex}$</TEX> = 12.2 Oe, and saturate to <TEX>$H_c$</TEX> = 5.8 Oe and <TEX>$H_{ex}$</TEX> = 3.5 Oe.
NSAID and Antioxidant Prevention of Alzheimer's Disease: Lessons from <i>In Vitro</i> and Animal Models (2004)

A bstract : Both oxidative damage and inflammation are elevated in brains of Alzheimer's disease (AD) patients, but their pathogenic significance remains unclear. The reduced AD risk associated with high intake of both nonsteroidal anti‐inflammatory drugs (NSAIDs) and antioxidants suggests causal roles, but clinical trials in AD patients have yielded only limited or negative results. To test the potential efficacy and mechanisms of candidate approaches, we have explored conventional and unconventional NSAIDs, antioxidants, and combined NSAID/antioxidants in cell culture and animal models for AD (including aging APPsw transgenic mice and soluble Aβ rodent infusion models). The conventional NSAID ibuprofen has the strongest epidemiological support. At sustainable doses designed to mimic protective consumption in the epidemiology, ibuprofen reduces amyloid accumulation but suppresses a surprisingly limited subset of inflammatory markers in APPsw transgenic mice. Both Ab production (APP, β‐ and γ‐secretases) and post‐production pathways (those affecting Aβ aggregation or clearance: e.g., IL‐1 or α1ACT) are potentially involved in ibuprofen and other NSAID anti‐AD activities. The post‐production pathways are predictably shared with other seemingly protective NSAIDs, including naproxen that do not lower Aβ42 in vitro . Using clinically feasible dosing, brain levels of NSAIDs appear too low to implicate a number of pharmacological dose targets that have been demonstrated in vitro . Ibuprofen did not suppress microglial markers related to phagocytosis. The putative anti‐inflammatory omega‐3 fatty acid DHA had a profound impact on pathogenesis but did not lower inflammation, while vitamin E was surprisingly ineffective in reducing oxidative damage or amyloid in the aged APPsw mouse. In contrast, the unconventional NSAID/antioxidant curcumin was effective, lowering oxidative damage, cognitive deficits, synaptic marker loss, and amyloid deposition. Curcumin proved to be immunomodulatory, simultaneously inhibiting cytokine and microglial activation indices related to neurotoxicity, but increasing an index of phagocytosis. Curcumin directly targeted Aβ and was also effective in other models, warranting further preclinical and clinical exploration.
Structural and functional features of the CD34 antigen: an update. (2001)

CD34 is a heavily glycosylated type I transmembrane molecule, that can be phoshorylated by a variety of kinases including Protein kinase C and Tyrosine kinases. The classification of epitopes detected by different CD34 MAbs has aided the selection of appropriate antibodies for use in specific clinical and research laboratory settings. Detailed structural analyses and cloning studies have confirmed that CD34 is a sialomucin, and have suggested that the fine composition of the carbohydrate moieties contained in its extended N-terminal region is important in determining its interactions with a variety of different ligands. For high endothelial venules (HEV) CD34 to serve as a ligand for L-selectin, the O-linked glycans of HEV CD34 are modified in an exquisitely specific manner with a variety of sialyl- and sulfo-transferases. In contrast, CD34 is not the ligand for L-selectin in hematopoietic stem/progenitor cells (HSPCs) and despite much endeavour, ligands for hematopoietic CD34 remain to be identified.
Arachidonic Acid and Other Fatty Acids Directly Activate Potassium Channels in Smooth Muscle Cells (1989)

Arachidonic acid, as well as fatty acids that are not substrates for cyclooxygenase and lipoxygenase enzymes, activated a specific type of potassium channel in freshly dissociated smooth muscle cells. Activation occurred in excised membrane patches in the absence of calcium and all nucleotides. Therefore signal transduction pathways that require such soluble factors, including the NADPH-dependent cytochrome P450 pathway, do not mediate the response. Thus, fatty acids directly activate potassium channels and so may constitute a class of signal molecules that regulate ion channels.
Entecavir: A New Treatment for Chronic Hepatitis B Infection (2006)

Hepatitis B virus can cause both acute and chronic liver disease in humans. Entecavir, a new, potent, orally administered guanosine analog for the treatment of chronic hepatitis B, has recently approved in the USA and Europe. Monotherapy with entecavir in nucleoside-naive patients has been associated with statistically superior histological improvement, greater reduction in hepatitis B virus-DNA levels, and improved normalization of alanine aminotransferase levels when compared with lamivudine. After 2 years of treatment, viral resistance to entecavir has not developed in the antiviral-naive patient population. Similar findings in terms of efficacy have also been observed in patients with lamivudine-resistant hepatitis B virus. The use of entecavir in the lamivudine-resistant patient population could lead to the development of entecavir-resistant mutants at the rate of 9% by 2 years. Entecavir is well tolerated with a good safety profile and should be considered as primary therapy for chronic hepatitis B. Entecavir may also be considered for use in the lamivudine-resistant patient at twice the dose recommended for nucleoside-naive patients, with the recognition that virologic breakthrough could develop.
Quantification of stromal destruction in the inflamed cornea. (1991)

An intrastromal injection of endotoxin lipopolysaccharide (LPS) in one eye of New Zealand albino rabbits induced a prominent keratitis characterized clinically and microscopically by edema and infiltration. Polymorphonuclear leukocytes (PMNs) constituted the primary invading leukocytic element. Collagen synthesis was measured by pulsing the corneas with 3H-proline before inducing inflammation. The invasion of the cornea by leukocytes did not alter the conversion of proline to hydroxyproline significantly in the stroma during the 14-day observation period, signifying that there were only negligible changes in the rate of collagen synthesis. However, the percentage of total stromal protein represented by collagen (ie, collagen/total protein) was only 50% of that in comparable corneas receiving an injection of phosphate-buffered saline. Some animals were rendered leukopenic by intravenous nitrogen mustard before intrastromal LPS injection caused a less severe corneal inflammatory response, characterized microscopically by fewer infiltrating leukocytes. Similarly, in nonleukopenic rabbits, topical therapy with 1% prednisolone acetate markedly reduced the corneal inflammatory response which also was characterized by fewer invading leukocytes. In neither instance was there extreme collagen loss, suggesting that the loss of stromal collagen is related to PMN infiltration.
Effect of<i>Citrullus colocynthis</i>. on Hair Growth in Albino Rats (2007)

Citrullus colocynthis. Schrad (Cucurbitaceae) is a traditionally acclaimed hair tonic in Ayurveda (the traditional Indian system of medicine). Studies were therefore undertaken to evaluate petroleum ether and ethanol extracts of C. colocynthis. for their effect on hair growth in albino rats. The extracts incorporated into oleaginous ointment base were applied topically on shaved denuded skin of albino rats. The time required for initiation of hair growth as well as completion of hair growth cycle was recorded. Minoxidil 2% solution was applied topically and served as the standard. Hair growth initiation time was significantly reduced to half on treatment with the petroleum ether extracts compared with untreated control animals. The time required for complete hair growth was also considerably reduced. The treatment was successful in bringing a greater number of hair follicles (>70%) to anagenic phase than standard minoxidil (67%). The result of treatment with 2 and 5% petroleum ether extracts were comparable with the standard minoxidil.
Levels of bovine papillomavirus RNA and protein expression correlate with variations in the tumorigenic phenotype of hamster cells (1987)

Three independent cell lines were established from primary cultures of LSH hamster embryo cells infected with bovine papillomavirus type 1 (BPV-1). Although these cell lines differed in their in vitro saturation densities, none was capable of colony formation in soft agar. Interestingly, two cell lines (BPV-HE1 and BPV-HE3) were tumorigenic in nude mice, syngeneic hamsters, and allogeneic hamsters, whereas BPV-HE2 was not. All three cell lines contained similar numbers of the BPV-1 genome (approximately 50 to 200 copies per cell). However, the nontumorigenic BPV-HE2 cell line contained very low levels of BPV-specific RNA and only small amounts of the BPV-1 E5 transforming protein. The efficiency and rate of tumor formation by BPV-HE1 and BPV-HE3 correlated directly with the apparent amount of viral E5 protein. This analysis suggests that there is a threshold level of BPV protein synthesis required for tumorigenicity, there is a continuum of tumorigenic phenotypes which may depend upon the level of BPV protein expression, and BPV-transformed hamster cells can withstand allogeneic transplantation.
TIPI: TEV Protease-Mediated Induction of Protein Instability (2012)

Reverse genetics approaches require methods to inactivate a specific protein. One possibility is to modify the target protein with a degradation signal (degron). Degrons are short, transferable sequences that confer protein instability. They target proteins for degradation either constitutively or after activation, e.g., by phosphorylation, presence of a binding partner, or conformational rearrangements in the substrate. In this chapter, we describe a synthetic way to activate a degron. It employs the generation of an N-degron by cleavage of a substrate with the site-specific tobacco etch virus (TEV) protease. Subsequently, the substrate is targeted for degradation by the ubiquitin-proteasome system. This TEV protease-induced protein instability system provides a powerful approach to generate conditional mutants for synthetic biology or for the investigation of protein functions in a specific cellular context.
An approach to peal-time control flow checking (2005)

A real-time control flow checking scheme capable of detecting control flow errors resulted from software coding errors, hardware malfunctions or memory mutilation is presented. In this approach, a data base containing the feasible path information in the source program is derived from the detailed design, and the path actually traversed at ruri-time is recorded and then checked using the information in the data base. This approach is general and detects in real-time most discrepancies between a program's control flow and its design. The overhead of using this approach will not be large. This approach can be also used to check the control flow in the testing phase of program development.
Axolemmal repair requires proteins that mediate synaptic vesicle fusion (2000)

A damaged cell membrane is repaired by a seal that restricts entry or exit of molecules and ions to that of the level passing through an undamaged membrane. Seal formation requires elevation of intracellular Ca(2+) and, very likely, protein-mediated fusion of membranes. Ca(2+) also regulates the interaction between synaptotagmin (Syt) and syntaxin (Syx), which is thought to mediate fusion of synaptic vesicles with the axolemma, allowing transmitter release at synapses. To determine whether synaptic proteins have a role in sealing axolemmal damage, we injected squid and crayfish giant axons with an antibody that inhibits squid Syt from binding Ca(2+), or with another antibody that inhibits the Ca(2+)-dependent interaction of squid Syx with the Ca(2+)-binding domain of Syt. Axons injected with antibody to Syt did not seal, as assessed at axonal cut ends by the exclusion of extracellular hydrophilic fluorescent dye using confocal microscopy, and by the decay of extracellular injury current compared to levels measured in uninjured axons using a vibrating probe technique. In contrast, axons injected with either denatured antibody to Syt or preimmune IgG did seal. Similarly, axons injected with antibody to Syx did not seal, but did seal when injected with either denatured antibody to Syx or preimmune IgG. These results indicate an essential involvement of Syt and Syx in the repair (sealing) of severed axons. We suggest that vesicles, which accumulate and interact at the injury site, re-establish axolemmal continuity by Ca(2+)-induced fusions mediated by proteins such as those involved in neurotransmitter release.
Two Widely Accessible Media for Growth and Reproduction of <i>Phytophthora</i> and <i>Pythium</i> Species (1993)

Tomato agar and soybean agar were found to be comparable to or in some cases better than the popular V8 vegetable juice agar in supporting linear growth of Phytophthora cactorum, Phytophthora capsici, Phytophthora parasitica, Pythium aphanidermatum, and Pythium splendens; sporangium production of P. capsici, P. palmivora, and Pythium splendens; and oospore formation of P. cactorum, P. parasitica, Pythium aphanidermatum and Pythium splendens. These two media with readily accessible ingredients can be used to substitute for V8 juice agar in pathological and physiological studies of these two important groups of fungi in countries where V8 vegetable juice is not available or difficult to obtain.
Micromachined curling optical switch array for PLC-based, integrated programmable add/drop multiplexer (2002)

We propose a micromachined optical switch array which is suitable for integration in planar lightwave circuit. A programmable add/drop multiplexer fabricated using the micromechanical processing and silica techniques demonstrates good performances and applicability to actual optical networks.
Laboratory von Hámos X-ray spectroscopy for routine sample characterization (2016)

High energy resolution, hard X-ray spectroscopies are powerful element selective probes of the electronic and local structure of matter, with diverse applications in chemistry, physics, biology, and materials science. The routine application of these techniques is hindered by the complicated and slow access to synchrotron radiation facilities. Here we propose a new, economic, easily operated laboratory high resolution von Hámos type X-ray spectrometer, which offers rapid transmission experiments for X-ray absorption and is also capable of recording X-ray emission spectra. The use of a cylindrical analyzer crystal and a position sensitive detector enabled us to build a robust, flexible setup with low operational costs, while delivering synchrotron grade signal to noise measurements in reasonable acquisition times. We demonstrate the proof of principle and give examples for both measurement types. Finally, tracking of a several day long chemical transformation, a case better suited for laboratory than synchrotron investigation, is also presented.
Electrochemical Scanning Tunneling Microscopy and Ultrahigh-Vacuum Investigation of Gold Cyanide Adlayers on Au(111) Formed in Aqueous Solution (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemical Scanning Tunneling Microscopy and Ultrahigh-Vacuum Investigation of Gold Cyanide Adlayers on Au(111) Formed in Aqueous SolutionTakahiro Sawaguchi, Taro Yamada, Yutaka Okinaka, and Kingo ItayaCite this: J. Phys. Chem. 1995, 99, 38, 14149–14155Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/j100038a056https://doi.org/10.1021/j100038a056research-articleACS PublicationsRequest reuse permissionsArticle Views361Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A log buffer-based flash translation layer using fully-associative sector translation (2007)

Flash memory is being rapidly deployed as data storage for mobile devices such as PDAs, MP3 players, mobile phones, and digital cameras, mainly because of its low electronic power, nonvolatile storage, high performance, physical stability, and portability. One disadvantage of flash memory is that prewritten data cannot be dynamically overwritten. Before overwriting prewritten data, a time-consuming erase operation on the used blocks must precede, which significantly degrades the overall write performance of flash memory. In order to solve this “erase-before-write” problem, the flash memory controller can be integrated with a software module, called “flash translation layer (FTL).” Among many FTL schemes available, the log block buffer scheme is considered to be optimum. With this scheme, a small number of log blocks, a kind of write buffer, can improve the performance of write operations by reducing the number of erase operations. However, this scheme can suffer from low space utilization of log blocks. In this paper, we show that there is much room for performance improvement in the log buffer block scheme, and propose an enhanced log block buffer scheme, called FAST (full associative sector translation). Our FAST scheme improves the space utilization of log blocks using fully-associative sector translations for the log block sectors. We also show empirically that our FAST scheme outperforms the pure log block buffer scheme.