gebhart/patrepeval huggingface dataset:
[Experimental and clinical studies on amoxicillin sustained-release preparation in the otorhinolaryngologic field]. (1982)

Fundamental and clinical evaluations of a new continual penicillin, C-AMOX, were performed. The results obtained were as follows. 1. Concentration in serum: The level of serum concentration after giving 500 mg of oral C-AMOX was determined in 3 cases of health adult. The maximal level measured 4.8 micrograms/ml at 4 hours after oral administration. Even 8 hours after oral administration, clinically effective serum C-AMOX concentration 1.6 micrograms/ml was still demonstrable. 2. Concentration of tissues: At 4 hours after a single oral dose of 500 mg, the concentration in the tissues of palatine tonsilla was 0.6 microgram/g as against 4.9 micrograms/ml in the serum, and the concentration in the tissues of mucous membrane of maxillary sinus was 0.5 microgram/g when measured 4.6 micrograms/ml in the serum. 3. Results of clinical treatment: C-AMOX of oral administration was tested in 46 cases of usually encountered acute an chronic infections in the otorhinolaryngologic field, the results being excellent in 25 cases, good in 14 cases and fair in 6 cases. When the excellent and good were bracketed together, it amounts to 39 cases (84.8%). It can be considered as high effective ratio. No side effect was shown with the oral administration of C-AMOX.
Genetic Polymorphism in<i>N</i>-Acetyltransferase (NAT): Population Distribution of NAT1 and NAT2 Activity (2009)

N-Acetyltransferases (NAT) are key enzymes in the conjugation of certain drugs and other xenobiotics with an arylamine structure. Polymorphisms in NAT2 have long been recognized to modulate toxicity produced by the anti-tubercular drug isoniazid, with molecular epidemiologic studies suggesting a link between acetylator phenotype and increased risk for bladder cancer. Recent evidence indicates that the other major NAT isozyme, NAT1, is also polymorphic. The current analysis characterizes the main polymorphisms in both NAT2 and NAT1 in terms of their effect on enzyme activity and frequency in the population. Multiple NAT2 alleles (NAT2*5, *6, *7, and *14) have substantially decreased acetylation activity and are common in Caucasians and populations of African descent. In these groups, most individuals carry at least one copy of a slow acetylator allele, and less than 10% are homozygous for the wild type (fast acetylator) trait. Incorporation of these data into a Monte Carlo modeling framework led to a population distribution of NAT2 activity that was bimodal and associated with considerable variability in each population assessed. The ratio of the median to the first percentile of NAT2 activity ranged from 7 in Caucasians to 18 in the Chinese population. This variability indicates the need for more quantitative approaches (e.g., physiologically based pharmacokinetic [PBPK] modeling) to assess the full distribution of internal dose and adverse responses to aromatic amines and other NAT2 substrates. Polymorphisms in NAT1 are generally associated with relatively minor effects on acetylation function, with Monte Carlo analysis indicating less interindividual variability than seen in NAT2 analysis.
Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells (1998)

Expression of peroxisome proliferator-activated receptor alpha (PPARalpha) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPARalpha/retinoid x receptor ligands, and FA all up-regulate PPARalpha and enzymes of FA oxidation and stimulate [3H]-palmitate oxidation in normal islets but not in islets from fa/fa rats. Overexpression of normal OB-R in islets of fa/fa rats corrects all of the foregoing abnormalities and reverses the diabetic phenotype. PPARalpha is a OB-R-dependent factor required for normal fat homeostasis in islet cells.
12-Oxophytodienoate-10,11-Reductase: Occurrence of Two Isoenzymes of Different Specificity against Stereoisomers of 12-Oxophytodienoic Acid (1998)

Abstract The reduction of 12-oxophytodienoic acid (OPDA) to 3-oxo-2(2′[Z]-pentenyl)-cyclopentane-1-octanoic acid is catalyzed by 12-oxophytodienoate-10,11-reductase (OPR). Analysis of the isomer preference of OPR has indicated that the activity is composed of two isoenzymes exhibiting different stereoselectivities. The two isoforms of OPR have been separated, using protein extracts of Rock Harlequin (Corydalis sempervirens) as the starting material. OPRI, the enzyme reported earlier from the same species and corresponding to the cloned OPR from Arabidopsis, utilized 9R,13R-OPDA &gt;&gt; 9S,13R-OPDA but not the 13S-configured isomers, whereas the new activity, OPRII, effectively reduced all four OPDA isomers, including the natural 9S,13S-OPDA (cis-[+]-OPDA). OPRII activity is characterized in detail. The enzyme's enzymatic, biochemical, and immunological properties prove that it is a close relative of OPRI. The roles of OPRI and OPRII in octadecanoid biology are discussed.
PWM technique for power MOSFET inverter (1988)

A sinusoidal PWM (pulsewidth-modulated) inverter suitable for use with power MOSFETs is described. The output waveforms in the proposed PWM inverter are investigated both theoretically and experimentally. A modulating signal for the three-phase PWM inverter is obtained by adding the harmonic components of integer multiples of three to the three-phase sine waves. By using the proposed modulating signal, the amplitude of the fundamental component is increased about 15% more than that of a conventional sine-wave inverter and the commutation number of the inverter is decreased to two-thirds of a conventional one.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
TrustZone Explained: Architectural Features and Use Cases (2016)

ARM TrustZone is a hardware security extension technology, which aims to provide secure execution environment by splitting computer resources between two execution worlds, namely normal world and secure world. TrustZone is supported on different flavors of ARM architectures, that include architecture deployed on targets running regular applications, such as mobile devices and architecture for micro-controllers. As ARM is widely deployed on the majority of mobile and micro-controller devices, TrustZone's goal is to provide security for those platforms. In this paper, we will discuss details of different ARM architectures that support TrustZone technology. Then, we will review how TrustZone is implemented in the hardware and software of ARM products. We will also compare TrustZone with other implementations of trusted execution environments on the market.
The effects of topical and systemic Beta glucan administration on wound healing impaired by corticosteroids. (2008)

These results indicate that systemic and topical beta glucan improve wound healing that has been impaired by corticosteroids, and that systemic administration is more effective than topical application.
Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma (2013)

We demonstrated that hypoxia-stabilized HIF1α promoted EMT through increasing SNAI1 transcription in HCC cells. This data provided a potential therapeutic target for HCC treatment.
Wireless Face Interface: Using voluntary gaze direction and facial muscle activations for human–computer interaction (2011)

Journal Article Wireless Face Interface: Using voluntary gaze direction and facial muscle activations for human–computer interaction Get access Outi Tuisku, Outi Tuisku * a Research Group for Emotions, Sociality, and Computing, Tampere Unit for Computer–Human Interaction (TAUCHI), School of Information Sciences, University of Tampere, Kanslerinrinne 1, FI-33014 University of Tampere, Finland * Corresponding author. Tel.: +358 3 3551 8893; fax: +358 3 3551 6070. E-mail addresses:Outi.Tuisku@uta.fi (O. Tuisku), Veikko.Surakka@uta.fi (V. Surakka), Toni.Vanhala@vtt.fi (T. Vanhala), Ville.Rantanen@tut.fi (V. Rantanen), Jukka.Lekkala@tut.fi (J. Lekkala). Search for other works by this author on: Oxford Academic Google Scholar Veikko Surakka, Veikko Surakka a Research Group for Emotions, Sociality, and Computing, Tampere Unit for Computer–Human Interaction (TAUCHI), School of Information Sciences, University of Tampere, Kanslerinrinne 1, FI-33014 University of Tampere, Finland Search for other works by this author on: Oxford Academic Google Scholar Toni Vanhala, Toni Vanhala a Research Group for Emotions, Sociality, and Computing, Tampere Unit for Computer–Human Interaction (TAUCHI), School of Information Sciences, University of Tampere, Kanslerinrinne 1, FI-33014 University of Tampere, Finlandc VTT Technical Research Centre of Finland, Tekniikankatu 1, P.O. Box 1300, FI-33101 Tampere, Finland Search for other works by this author on: Oxford Academic Google Scholar Ville Rantanen, Ville Rantanen b Sensor Technology and Biomeasurements, Department of Automation Science and Engineering, Tampere University of Technology, P.O. Box 692, FI-33101 Tampere, Finland Search for other works by this author on: Oxford Academic Google Scholar Jukka Lekkala Jukka Lekkala b Sensor Technology and Biomeasurements, Department of Automation Science and Engineering, Tampere University of Technology, P.O. Box 692, FI-33101 Tampere, Finland Search for other works by this author on: Oxford Academic Google Scholar Interacting with Computers, Volume 24, Issue 1, January 2012, Pages 1–9, https://doi.org/10.1016/j.intcom.2011.10.002 Published: 29 October 2011 Article history Received: 27 January 2011 Revision received: 10 October 2011 Accepted: 20 October 2011 Published: 29 October 2011
Syntheses and Circular Dichroism Studies of Oligopeptides Having Tri- or Tetra-<scp>l</scp>-prolyl Sequences (1984)

Abstract CD spectra of many oligopeptides having tri- or tetra-l-prolyl sequences showed that a penta- or hexapeptide having a tetra-l-prolyl sequence took poly(l-proline) II helix irrespective of amino acid residues at N- or C-terminal of a l-prolyl cluster and that as to a size of the cluster, tri-l-prolyl sequence was enough to form the helix, when glycine was used as substituent.
A real time color gamut mapping using tetrahedral interpolation for digital tv color reproduction enhancement (2009)

In this paper, a tetrahedral interpolation technique is utilized to build new type architecture for real time color gamut mapping which has been known to be one of promising methods to enhance display quality of digital and/or high-definition TV. It is common practice to simplify the required complex computations for the mapping by adopting three-dimensional interpolation techniques. If carefully arranged, the tetrahedral interpolation can be computed with simpler operations compared to the other types of interpolation such as a cubic or three-bilinear interpolation in the conventional reduced resolution look-up table. With these simplified operations, the proposed method reduces the required computational cost and the complexity of hardware implementation. The proposed method is implemented in VHDL code and the simulation results show that the proposed method reduces the number of gates needed to hardware implementation without loss of color reproduction quality.
Crystal x-ray accelerator (1987)

An ultimate linac structure is realized by an appropriate crystal lattice (superlattice) that serves as a ``soft'' irised waveguide for x rays. High-energy (\ensuremath{\sim}40 keV) X rays are injected into the crystal at the Bragg angle to cause Bormann anomalous transmission, yielding slow-wave accelerating fields. Particles (e.g., muons) are channeled along the crystal axis.
Pulsed doppler ultrasound detection of flow disturbances in arteriosclerosis (1976)

Pulsed Doppler ultrasound blood flow detection has been used in a noninvasive manner to detect arterial abnormalities associated with arteriosclerosis. Sound spectrograms of ultrasound signals obtained from in vitro and animal studies in which flow was disturbed by obstacles placed in the flow stream showed a different distribution of energy over frequency than signals obtained from studies with no flow disturbances. Similar findings were seen clinically. A technique has been developed which can detect disturbed flow patterns resulting from partial occlusion in important superficial arteries (e.g. femoral and carotid) up to 15 cm distal to localized arterial wall abnormalities. Thirty-five arterial examinations of normal and arteriographically abnormal arteries in 12 patients revealed a sensitivity of 83 percent and a specificity of 61 percent. This study suggests that pulsed Doppler ultrasound may be useful as a screening technique for detection of arteriosclerotic lesions in major superficial arteries.
Tomorrow's campus (1994)

article Free AccessTomorrow's campus Author: Larry Press California State Univ., Dominguez Hills California State Univ., Dominguez HillsView Profile Authors Info & Claims Communications of the ACMVolume 37Issue 7July 1994 pp 13–17https://doi.org/10.1145/176789.176806Published:01 July 1994Publication History 8citation685DownloadsMetricsTotal Citations8Total Downloads685Last 12 Months9Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Antydemoniczny charakter sakramentu Eucharystii (2018)

Życie i dzieło Jezusa Chrystusa ma charakter zbawczy i wyzwalający z mocy złego ducha. Z tej perspektywy ustanowienie Eucharystii i dawanie się wiernym jako Pokarm to dzieła wybitnie antydemoniczne, które uwalniają spod władzy duchów ciemności i stanowią niezbędną pomoc zarówno dla chrześcijan w codziennej walce duchowej, jak i dla opętanych na drodze do uwolnienia.Również warstwa liturgiczna tego sakramentu zawiera wiele odniesień do chwalebnego zwycięstwa Chrystusa nad Szatanem i nieustanne błaganie o zachowanie ludzi od jego wpływu. Eucharystia nie stanowi jednak narzędzia do wyzwolenia opętanych z mocy demona, lecz jest fundamentalnym elementem procesu wyzwolenia poprzez egzorcyzm.
Efficient eradication of hormone‐resistant human prostate cancers by inactivated Sendai virus particle (2008)

Hormone-refractory prostate cancer is one of the intractable human cancers in the world. Here, we examined the direct tumor-killing activity of inactivated Sendai virus particle [hemagglutinating virus of Japan envelope (HVJ-E)] through induction of Type I interferon (IFN) in the hormone-resistant human prostate cancer cell lines PC3 and DU145. Preferential binding of HVJ-E to PC3 and DU145 over hormone-sensitive prostate cancer cell and normal prostate epithelium was observed, resulting in a number of fused cells. After HVJ-E treatment, a number of IFN-related genes were up-regulated, resulting in Type I IFN production in PC3 cells. Then, retinoic acid-inducible gene-I (RIG-I) helicase which activates Type I IFN expression after Sendai virus infection was up-regulated in cancer cells after HVJ-E treatment. Produced IFN-alpha and -beta enhanced caspase 8 expression via Janus kinases/Signal Transducers and Activators of Transcription pathway, activated caspase 3 and induced apoptosis in cancer cells. When HVJ-E was directly injected into a mass of PC3 tumor cells in SCID (severe combined immunodeficiency) mice, a marked reduction in the bulk of each tumor mass was observed and 85% of the mice became tumor-free. Although co-injection of an anti-asialo GM1 antibody with HVJ-E into each tumor mass slightly attenuated the tumor suppressive activity of HVJ-E, significant suppression of tumor growth was observed even in the presence of anti-asialo GM1 antibody. This suggests that natural killer cell activation made small contribution to tumor regression following HVJ-E treatment in hormone-resistant prostate cancer model in vivo. Thus, HVJ-E effectively targets hormone-resistant prostate cancer by inducing apoptosis in tumor cells, as well as activating anti-tumor immunity.
Caenorhabditis elegansContains Two Distinct Acid Sphingomyelinases (1998)

Mounting evidence supports a role for acid sphingomyelinase (ASM) in cellular stress signaling. Only murine and human sphingomyelinases have been defined at the molecular level. These enzymes are the products of a conserved gene and at the amino acid level share 82% identity. In this study, we show that the nematode Caenorhabditis elegans possesses two ASMs, termed ASM-1 and ASM-2 encoded by two distinct genes, but lacks detectable neutral sphingomyelinase activity. The C. elegans ASMs are about 30% identical with each other and with the human and murine enzymes. The conserved regions include a saposin-like domain, proline-rich domain, and a putative signal peptide. In addition, 16 cysteines distributed throughout the molecules, and selected glycosylation sites, are conserved. The expression of these genes in C. elegans is regulated during development. Asm-1 is preferentially expressed in the embryo, whereas asm-2 is predominantly expressed in postembryonic stages. When transfected as Flag-tagged proteins into COS-7 cells, ASM-1 is found almost entirely in a secreted form whereas only 20% of ASM-2 is secreted. Only the secreted forms display enzymatic activity. Furthermore, ASM-2 requires addition of Zn2+ to be fully active, whereas ASM-1 is active in the absence of cation. C. elegans is the first organism to display two ASMs. This finding suggests the existence of an ASM gene family.
Small-angle x-ray-scattering study of silver-nanocrystal disorder-order phase transitions (1999)

A conceptually unique approach was developed to study the interparticle interactions between organized alkanethiol-capped silver nanocrystals. Dense nanocrystal fluids were formed by evaporating the solvent from a ``size-polydisperse'' $(\ensuremath{\sigma}\ifmmode\pm\else\textpm\fi{}12%)$ nanocrystal dispersion on a substrate. The sample polydispersity prevented the disorder-order phase transition (i.e., superlattice formation) from occurring. Small-angle x-ray scattering was then used to measure the static structure factors $S(q),$ of these disordered nanocrystal films as a function of the ratio $〈L〉/R$ between the capping ligand chain length to the core nanocrystal radius. The pair-distribution and direct correlation functions were then calculated from Fourier transformations of $S(q).$ This enabled the use of the hypernetted chain approximation to calculate the pair interparticle potential $u(r).$ The 6-12 Lennard-Jones potential provided reasonable fits to all experimentally determined values of $u(r),$ indicating the predominance of relatively short-range repulsion between nanocrystals. Monodisperse dodecanethiol- and octanethiol-capped silver nanocrystals were then condensed into ordered arrays. Face-centered-cubic (fcc) packing was favored for $〈L〉/R<0.60,$ and body-centered-cubic (bcc) packing was favored when $〈L〉/R>0.60.$ Lower-symmetry body-centered-tetragonal packing was observed for octanethiol-capped silver nanocrystals with $〈L〉/R>0.66.$ A simple model employing the experimentally determined values for $u(r),$ predicts that the $\mathrm{fc}\stackrel{\ensuremath{\rightarrow}}{c}\mathrm{bcc}$ superlattice phase transition occurs when $〈L〉/R0.65.$
A Tool for Architecting Socio-Technical Problems: SoS Explorer (2019)

Socio-Technical systems entail complex logic with many levels of reasoning. These systems are organized by web of connections which gives rise of system of systems (SoS) and can demonstrate self-driven capability. Non-linear relationship among the participating systems results emergent behavior which is not deterministic. Therefore, architecting a SoS with complex, dynamic and evolving systems is not trivial. The challenge is to create organized complexity that will allow individual system to achieve its goals that are dynamically changing. To address the challenge, SoS Explorer, a SoS architecting tool can be used to define, formulate, and solve numerous socio-technical problems. SoS explorer integrates fuzzy inference system with genetic algorithm guiding the optimization process in generating meta-architecture which provides the best possible value for overall objective of SoS. This paper presents the capability of SoS explorer to generate, assess and select a SoS meta architecture for Intelligent Transportation System as the application domain.
Total Parenteral Nutrition During Pregnancy in a Patient Requiring Long‐Term Nutrition Support (1998)

Patients on long-term TPN can conceive successfully and carry a pregnancy to term without any adverse outcome for the mother or the fetus. TPN feeding during pregnancy and recommendations for maternal weight gain are reviewed.
9.7 A Scalable 71-to-76GHz 64-Element Phased-Array Transceiver Module with 2×2 Direct-Conversion IC in 22nm FinFET CMOS Technology (2019)

Fifth-generation cellular communication standards (5G) target Gb/s data-rates, pushing the industry beyond the sub-6GHz bands. Tens of GHz of spectrum are available in the frequency bands from 30 to 300GHz. To maintain acceptable link budgets with sufficient antenna apertures, arrays are typically required at these frequencies and electrical beam steering is needed to retain spatial coverage. For such complex systems, highly-integrated, low-cost and energy-efficient SoCs are desirable to enable volume deployment. FinFET technologies are an ideal candidate to tackle this challenging integration, given the excellent balance between density and RF/mm-wave performance that has been recently demonstrated [1].
Cyclic AMP phosphodiesterase in Salmonella typhimurium: characteristics and physiological function (1984)

The physiological function of cyclic AMP (cAMP) phosphodiesterase in Salmonella typhimurium was investigated with strains which were isogenic except for the cpd locus. In crude broken-cell extracts the properties of the enzyme were found to be similar to those reported for Escherichia coli. The specific activity in the mutant was less than 1% that in the wild type. Rates of cAMP production in the mutant were as much as twice those observed in the wild type. The amount of cAMP accumulated when cells grew overnight with limiting glucose was 4.5-fold greater in the mutant than in the wild type. The intracellular concentration of cAMP in the two strains was measured directly, using four different techniques to wash the cells to remove extracellular cAMP. The cAMP level in the cpd strain was only 25% greater than in the wild type. The functional concentration of the cAMP receptor protein-cAMP complex was estimated indirectly from the specific activity of beta-galactosidase in the two strains after introducing F'lac. When cells were grown with carbon sources permitting synthesis of different levels of cAMP, the specific activity of the enzyme was at most 25% greater in the cpd strain. The cpd strain was more sensitive to the effects of exogenous cAMP. Exogenous cAMP relieved both permanent and transient catabolite repression of the lac operon at lower concentrations in the cpd strain than in the wild type. When cells grew with glucose, glycerol, or ribose, exogenous cAMP inhibited growth of the mutant strain more than the wild type.