gebhart/patrepeval huggingface dataset:
Spontaneous sustained pregnancy-associated hypertension in SHHF/Mcc-facp rats: a possible model for impaired blood pressure regulation in pregnant women (2000)

Hypertension is a major contributor to maternal and fetal morbidity and mortality, with the potential to result in maternal death, intrauterine growth retardation, and the need for iatrogenic preterm delivery of infants. Progress in understanding the pathogenesis of hypertensive disorders of pregnancy has been slowed by the scarcity of animal models that develop the disorders spontaneously and in so doing model the situation in humans. Twenty nulliparous 5-month-old female SHHF/Mcc-facp (SHHF) rats were matched by initial tail cuff systolic blood pressure and randomly assigned to either breeding or control groups. A small group of 4 females became pseudopregnant after breeding. Initial blood pressure was mildly elevated at 141 (±2.5, SEM) mm Hg. Systolic blood pressures were recorded in all females every other day and the pressures of pseudopregnant and pregnant females were significantly greater than controls at day 6 of pregnancy, reaching a plateau by 8–10 days of pregnancy at approximately 40 mm Hg higher than nonpregnant control rats. Blood pressure began to decline in pseudopregnant females at day 12 of pregnancy, but was persistently high until after delivery in pregnant females. Half of the pregnant females were sacrificed at day 21 of gestation, and the remainder were allowed to deliver. Interestingly, despite the sustained hypertension, the mean heart weight of the hypertensive pregnant rats was 1.2 (±0.02, SEM) g, similar to normotensive females of this age and in contrast to older. Nonpregnant females of this strain with blood pressures in this range have an average heart weight of 1.6–1.8 g, suggesting that the expected cardiac hypertrophy did not develop in pregnant hypertensive females. Placental weights from sacrificed females at day 21 of gestation (0.60 ± 0.02, n = 34) were larger than those reported for spontaneously hypertensive rats (SHRs), but pup weights (2.68 ± 0.64, n = 36) were comparable. Histologic examination of the left ventricle, liver, kidney, and placenta did not reveal pathologic lesions. Thus, SHHF rats which develop pregnancy-associated hypertension had small for gestational age pups similar to SHRs but larger placental weights. The SHHF rat may be of significance as a model of spontaneous pregnancy-associated hypertension and altered rates of intrauterine growth.
Perceptual and Instrumental Analysis of Laryngeal Function After Traumatic Brain Injury in Childhood (2003)

As a group, the children with TBI demonstrated normal, or only minimally impaired laryngeal function, when compared with the control group, which contrasts with the significant laryngeal impairment noted in adults after TBI. Several reasons for the different findings in relation to laryngeal function in adults and children after TBI are postulated: (1) differing types of injury usually incurred by adults and children may result in a relatively decreased degree of neurologic impairment in these children, (2) differences in recovery potential between adults and children, and (3) the pediatric larynx is still developing, hence it may be better able to compensate for any impairment incurred.
Therapeutic trials for traumatic brain injury—A journey in progress * (2002)

Cerebral Vascular Disease Research Center Department of Neurology University of Miami School of Medicine Miami, FL *See also p. 739.
Semantic Locations in Online Communities (2007)

Humans usually think of a location not as pair of coordinates but rather in a semantic way as place. In this paper, we are presenting a concept to integrate places in a framework for the development of user- centered community platforms. We follow a grassroots approach for collecting places and introduce an ontology-based place model along with concepts for mapping geographic coordinates to places. Furthermore, a place cloud is established as an intuitive user interface for localization, place visualization, and the retrieval of multimedia contents based on places. The prototypical implementation of our concepts proofs that places are well suited for personalization and the semantic annotation of multimedia contents in a social environment.
Sub-wavelength transmission and reflection mode tabletop imaging with 13nm illumination via ptychography CDI (2017)

EUV lithography is promising for addressing upcoming, <10nm nodes for the semiconductor industry, but with this promise comes the need for reliable metrology techniques. In particular, there is a need for actinic mask inspection in which the imaging wavelength matches that of the intended lithography process, so that the most relevant defects are detected. Here, we demonstrate tabletop, ptychographic, coherent diffraction imaging (CDI) in reflection- and transmission-modes of extended samples, using a 13 nm high harmonic generation (HHG) source. We achieve the first sub-wavelength resolution EUV image (0.9λ) in transmission, the highest spatial resolution using any 13.5 nm source to date. We also present the first reflection-mode image obtained on a tabletop using 12.7 nm light. This work represents the first 12.7 nm reflection-mode image using any source of a general sample.
Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo (2006)

The proteasome inhibitor bortezomib (Velcade) was recently approved for the treatment of therapy-refractive multiple myeloma and is under investigation for numerous other types of cancer. A phase I clinical trial in paediatric patients resulted in tolerable toxicity. Since the emergence of chemoresistance represents one of the major drawbacks in cancer therapy, we investigated the influence of bortezomib on multi-drug resistant human neuroblastoma cell lines characterised by P-glycoprotein expression and p53 mutation. Nanomolar concentrations of bortezomib inhibited the cell cycle and induced apoptosis in chemosensitive as well as in chemoresistant cell lines. In vivo growth of chemosensitive and chemoresistant neuroblastoma cell lines was inhibited to a similar extent. In addition, bortezomib inhibited vessel formation in neuroblastoma xenografts. These findings and the favourable toxicity profile of bortezomib in children make it reasonable to further pursue additional development of the drug for the treatment of neuroblastoma and other paediatric solid tumours.
The directory-enabled enterprise (1999)

The network directory, formerly just a background technology for storing resource and user profiles, is now becoming a powerful tool for policy-based management. New directory products can store policies to regulate how users and applications access network resources. And a new breed of directory services permits linking directories for global updates or to marshal resources for critical tasks. For example, storing access policies in directory objects, such as user names, could efficiently provide authentication and authorization for internal users and even extranet users. This promises to make directories a much more important technology for administrators, particularly as they increasingly seek to improve network management by more closely controlling the relationship between applications and resources.
Oral and Subcutaneous Administration of a Near-Infrared Fluorescent Molecular Imaging Agent Detects Inflammation in a Mouse Model of Rheumatoid Arthritis (2019)

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that causes irreversible damage to the joints. However, effective drugs exist that can stop disease progression, leading to intense interest in early detection and treatment monitoring to improve patient outcomes. Imaging approaches have the potential for early detection, but current methods lack sensitivity and/or are time-consuming and expensive. We examined potential routes for self-administration of molecular imaging agents in the form of subcutaneous and oral delivery of an integrin binding near-infrared (NIR) fluorescent imaging agent in an animal model of RA with the long-term goal of increasing safety and patient compliance for screening. NIR imaging has relatively low cost, uses non-ionizing radiation, and provides minimally invasive spatial and molecular information. This proof-of-principle study shows significant uptake of an IRDye800CW agent in inflamed joints of a collagen antibody induced arthritis (CAIA) mouse model compared to healthy joints, irrespective of the method of administration. The imaging results were extrapolated to clinical depths in silico using a 3D COMSOL model of NIR fluorescence imaging in a human hand to examine imaging feasability. With target to background concentration ratios greater than 5.5, which are achieved in the mouse model, these probes have the potential to identify arthritic joints following oral delivery at clinically relevant depths.
Calibration-free absolute quantification of particle concentration by statistical analyses of photoacoustic signals<i>in vivo</i> (2014)

Currently, laser fluence calibration is typically required for quantitative measurement of particle concentration in photoacoustic imaging. Here, we present a calibration-free method to quantify the absolute particle concentration by statistically analyzing photoacoustic signals. The proposed method is based on the fact that Brownian motion induces particle count fluctuation in the detection volume. If the count of particles in the detection volume is assumed to follow the Poisson distribution, its expected value can be calculated by the photoacoustic signal mean and variance. We first derived a theoretical model for photoacoustic signals. Then, we applied our method to quantitative measurement of different concentrations of various particles, including red blood cells. Finally, we performed in vivo experiments to demonstrate the potential of our method in biological applications. The experimental results agreed well with the predictions from the theoretical model suggesting that our method can be used for noninvasive measurement of absolute particle concentrations in deep tissue without fluence calibration.
Leptin levels in rat offspring are modified by the ratio of linoleic to α-linolenic acid in the maternal diet (2002)

The supply of polyunsaturated fatty acids (PUFA) is important for optimal fetal and postnatal development. We have previously shown that leptin levels in suckling rats are reduced by maternal PUFA deficiency. In the present study, we evaluated the effect of maternal dietary intake of (n-3) and (n-6) PUFA on the leptin content in rat milk and serum leptin levels in suckling pups. For the last 10 days of gestation and throughout lactation, the rats were fed an isocaloric diet containing 7% linseed oil (n-3 diet), sunflower oil (n-6 diet), or soybean oil (n-6/n-3 diet). Body weight, body length, inguinal fat pad weight, and adipocyte size of the pups receiving the n-3 diet were significantly lower during the whole suckling period compared with n-6/n-3 fed pups. Body and fat pad weights of the n-6 fed pups were in between the other two groups at week one, but not different from the n-6/n-3 group at week 3. Feeding dams the n-3 diet resulted in decreased serum leptin levels in the suckling pups compared with pups in the n-6/n-3 group. The mean serum leptin levels of the n-6 pups were between the other two groups but not different from either group. There were no differences in the milk leptin content between the groups. These results show that the balance between the n-6 and n-3 PUFA in the maternal diet rather than amount of n-6 or n-3 PUFA per se could be important for adipose tissue growth and for maintaining adequate serum leptin levels in the offspring.
Partial purification and characterization of an antigen-specific helper factor synthesized by a T-cell continuous line. (1983)

Antigen-specific factors produced by the T-cell growth factor-dependent T-cell continuous line E-9M(+) were partially purified. Gel analysis of the twice-affinity-purified eluate of a poly(Tyr,Glu)-poly(DLAla)--poly(LLys) [(T,G)-A--L] column revealed the existence of iodinated bands with molecular weights of 17,000 and 15,000, in addition to a diffuse band of high molecular weight. The specific helper activity of the E-9M(+) supernatants was associated with a precipitate from 65-75% ammonium sulfate. Gel electrophoresis of either the eluate of a (T,G)-A--L column or of the 65-75% salt precipitate indicated that in both preparations two fractions contained the biological activity of the factor, one of a high (less than 67,000) molecular weight and the other of a low (15,000-17,000) one. Culture supernatants of the internally [35S]methionine-labeled E-9M(+) line were subjected to a combined purification of sequential ammonium sulfate precipitations, followed by affinity chromatography. Polyacrylamide gel patterns obtained of the eluates of the different salt precipitates demonstrated that the 65-75% ammonium sulfate precipitate contained two 35S-labeled bands with apparent molecular weights in the range of 60,000 and 15,000, similar to the activity patterns obtained by the gel electrophoresis fractionation experiments. Thus, it is suggested that a fraction of low molecular weight preserves the antigen specificity and the helper activity of the factor produced by the T-cell line.
Stability of the hydrophilic behavior of oxygen plasma activated SU-8 (2007)

The effect of O2 plasma treatment on surface energy, topography and surface chemistry of the negative photoresist epoxy novolak SU-8 was investigated by contact angle goniometry, atomic force microscopy (AFM) and x-ray photoelectron spectroscopy (XPS). Directly after plasma treatment, the surfaces were completely wetted by water with a contact angle between water and the SU-8 surface below 5°. The surface free energy can be increased significantly depending on the plasma dose. The surfaces remained hydrophilic for several months showing a moderate hydrophobic recovery. The surface topography of the plasma treated SU-8 showed a formation of nanoscale aggregates. The rms-roughness of the topography was correlated with the plasma dose. An increased plasma dose induced aggregates of up to 200 nm in size. XPS measurements revealed changes in surface chemistry due to the oxygen plasma process and an increased antimony concentration on the surface.
Genetic analysis of adenine metabolism in Leishmania donovani promastigotes. Evidence for diploidy at the adenine phosphoribosyltransferase locus. (1984)

Mutant promastigotes of Leishmania donovani deficient in adenine phosphoribosyltransferase (AP-Rib transferase) have been isolated in medium containing 4-aminopyrazolopyrimidine. The generation of AP-Rib transferase-deficient mutants occurred in two discrete steps. In the first step, clones were isolated with 50% of wild-type levels of AP-Rib transferase activity. These cells were reselected, and colonies totally deficient in AP-Rib transferase were isolated. Wild-type and AP-Rib transferase-deficient cells contained equivalent amounts of other enzymes essential to adenine metabolism such as adenine deaminase and hypoxanthine-guanine phosphoribosyltransferase. Partially and totally AP-Rib transferase-deficient cells exhibited intermediate and complete resistance to cytotoxic adenine analogs, respectively. Nevertheless, wild-type and mutant cells could salvage adenine and utilize adenine as a purine source equally efficiently, suggesting that the adenine deaminase-hypoxanthine-guanine phosphoribosyl-transferase pathway plays an important role in promastigote adenine metabolism. Kinetic and thermal inactivation studies of purified AP-Rib transferase and isoelectric focusing of crude extracts from wild-type and partially AP-Rib transferase-deficient cells suggested that the latter cells possessed wild-type AP-Rib transferase activity at half the amount found in wild-type parental cells. These data suggest that L. donovani possesses two copies of the AP-Rib transferase structural gene and that these organisms might be diploid for the AP-Rib transferase locus.
ChemInform Abstract: Tellurium and Its Compounds (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Programming multicomputers using shared objects (2002)

Multiprocessors and multicomputers differ in important ways in terms of hardware and software. One kind of machine is hard to build but easy to program, and the other is easy to build but hard to program. We believe that by using shared objects as a programming paradigm, it is possible to combine the best properties of these two models. In this paper, we describe how it can be done. Our solution is based on having the programmer declare objects that can be potentially shared among processes on all machines in the system. These objects are passive-they are invoked by threads, but do not themselves contain internal threads. The shared objects act as though they are in a common shared memory (even though they are not), and can be accessed by all authorized processes by simply invoking their methods. Each method operates only on a single object.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Darwin information typing architecture (DITA): applications for globalization (2005)

Translation of documentation has traditionally been a major expense in the globalization process, especially if translations are required for multiple languages. The Darwin Information Typing Architecture (DITA) is an XML-based architecture for creating topic-based and information-typed content. It provides a number of features that, in addition to supporting high-quality information delivery, allows for more efficient and reliable localization of information. This article provides both an introduction to DITA and a discussion of DITA features that enhance document globalization.
Protease Inhibitors: Candidate Drugs to Inhibit Severe Acute Respiratory Syndrome Coronavirus 2 Replication (2020)

The number of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly increased, although the WHO declared a pandemic. However, drugs that function against SARS-CoV-2 have not been established. SARS-CoV-2 has been suggested to bind angiotensin-converting enzyme 2, the receptor of the SARS coronavirus. SARS coronavirus and coronavirus 229E, the cause of the common cold, replicate through cell-surface and endosomal pathways using a protease, the type II transmembrane protease. To examine the effects of protease inhibitors on the replication of coronavirus 229E, we pretreated primary cultures of human nasal epithelial (HNE) cells with camostat or nafamostat, each of which has been used for the treatment of pancreatitis and/or disseminated intravascular coagulation. HNE cells were then infected with coronavirus 229E, and viral titers in the airway surface liquid of the cells were examined. Pretreatment with camostat (0.1-10 μg/mL) or nafamostat (0.01-1 μg/mL) reduced the titers of coronavirus 229E. Furthermore, a significant amount of type II transmembrane protease protein was detected in the airway surface liquid of HNE cells. Additionally, interferons have been reported to have antiviral effects against SARS coronavirus. The additive effects of interferons on the inhibitory effects of other candidate drugs to treat SARS-CoV-2 infection, such as lopinavir, ritonavir and favipiravir, have also been studied. These findings suggest that protease inhibitors of this type may inhibit coronavirus 229E replication in human airway epithelial cells at clinical concentrations. Protease inhibitors, interferons or the combination of these drugs may become candidate drugs to inhibit the replication of SARS-CoV-2.
Intra-arterial thrombolytic therapy improves outcome in patients with acute vertebrobasilar occlusive disease. (1988)

In this retrospective analysis we report our treatment experience in 65 consecutive patients with clinical signs of severe brainstem ischemia with angiographically demonstrated thrombotic vertebrobasilar artery occlusions who received either local intra-arterial thrombolytic therapy (urokinase or streptokinase) (43 patients) or conventional therapy (antiplatelet agents or anticoagulants) (22 patients). We analyzed the data with respect to cerebral artery occlusion patterns, posttreatment arterial recanalization, and the clinical categories of favorable/unfavorable outcome and survival/death. In subgroup analyses, recanalization in patients who received thrombolytic therapy correlated significantly with clinical outcome; in 19 of 43 patients, recanalization was demonstrated angiographically, while in 24 patients the occlusion persisted. All patients without recanalization died, but 14 of the 19 patients displaying recanalization survived (p = 0.000007), 10 with a favorable clinical outcome. Only three of the 22 patients who received conventional therapy survived, all with a moderate clinical deficit. When we compared the treatment groups, highly significant differences in both outcome quality (p = 0.017) and survival (p = 0.0005) were found to depend on establishing recanalization. Our data support the concept that technically successful thrombolysis of vertebrobasilar artery occlusions is associated with beneficial clinical outcome.
HYDROMAGNETIC ASPECTS OF SOLAR WIND FLOW PAST THE MOON. (1970)

Solar wind interaction with moon, constructing mathematical model based on MHD equations and Explorer 35 data
A page-swapping prototype for VM/HPO (1987)

This paper discusses a series of changes that were made to a system running the Virtual Machine/System Product with the High Performance Option to enhance paging. The motivation and the background for these enhancements are discussed, and the design of a series of experimental paging subsystems is described and contrasted with the old design: specifically, the new algorithms for main memory management, block paging, working set identification, trimming, prepaging, page replacement, page-out device selection, and page-out slot selection. The performance impact of these changes is illustrated by results of benchmark measurements, which are then contrasted to measurements without the enhancements. Some things learned in running the prototype are discussed and conclusions drawn.
Effect of image size on the color appearance of image reproductions using colorimetrically calibrated LCD and DLP displays (2006)

Abstract— Archiving images of cultural heritage based on spectral imaging techniques is an active research area in imaging science. Original and reproduced art are usually viewed under quite different viewing conditions. One of the interesting differences in viewing condition is size difference. This leads to different surrounds and adaptation states. In order to investigate the effect of size in color perception of rendered images, a visual experiment was conducted using a colorimetrically characterized digital projector and LCD. An image was rendered and projected on the screen. The same image was processed using various algorithms followed by rendering for the LCD. These LCD rendered images, by definition, were considerably smaller than the projected image. Using a paired‐comparison method, the effect of image size was investigated using a colorimetric image of Georges Seurat's, “Sunday Afternoon on the Island of La Grande Jatte — 1884.” The image rendered for an LCD with a linear increase in lightness resulted in a closer match to the image projected on screen than an original colorimetrically rendered image and was perceived as a more accurate reproduction than the majority of algorithms tested.