gebhart/patrepeval huggingface dataset:
Heat Deterioration of Phospholipids I: Decomposition of Soybean Lecithin and Formation of New Products by Heating. (2001)

The heat decomposition of soybean lecithin was studied using saturated hydrocarbon. On heating with isooctane for 18 hrs, phospholipid composition did not change, but solution color went to yellowish brown. The main coloring substances were separated by silica gel column chromatography and were found to be negative to Dittmer-Lester’s reagent. These substances were mixed polyene compounds possessing a small amount of carbonyl compounds. No exact determination was made of their structures. These substances were also found present in pre-heated soybean lecithin and their amounts increase on heating. The coloring of soybean lecithin on heating under 100°C is thus not due to decomposition of phospholipids, but the presence of polyene substances. On heating with octane for 9 hrs, the phospholipids decomposed but each at a different rate with residual amounts as follows : phosphatidylcholine (PC), 98% ; phosphatidylinositol (PI), 80% ; phosphatidic acid (PA), 65% ; phosphatidylethanolamine (PE), 0%. By heating with decane, PI, PA, and PE decomposed within 1 hr, while PC did so slowly, with 3.5% remaining at 9 hrs. With octane solution color quickly became deep brown. In the isolation of these browning substances, attention was directed to substances having absorption maxima at 350 nm. On heating soybean lecithin, substances having absorption maxima at 240 nm and 280 nm have previously been noted but not those with absorption maxima at 350 nm. The separation and purification of these new products will appear in a future paper.
?-Carotene production in sugarcane molasses by a Rhodotorula glutinis mutant (2001)

Several wild strains and mutants of Rhodotorula spp. were screened for growth, carotenoid production and the proportion of -carotene produced in sugarcane molasses. A better producer, Rhodotorula glutinis mutant 32, was optimized for carotenoid production with respect to total reducing sugar (TRS) concentration and pH. In shake flasks, when molasses was used as the sole nutrient medium with 40 g l(-1) TRS, at pH 6, the carotenoid yield was 14 mg l(-1) and -carotene accounted for 70% of the total carotenoids. In a 14-l stirred tank fermenter, a 20% increase in torulene content was observed in plain molasses medium. However, by addition of yeast extract, this effect was reversed and a 31% increase in -carotene content was observed. Dissolved oxygen (DO) stat fed-batch cultivation of mutant 32 in plain molasses medium yielded 71 and 185 mg l(-1) total carotenoids in double- and triple-strength medium, respectively. When supplemented with yeast extract, the yields were 97 and 183 mg l(-1) total carotenoid with a 30% increase in -carotene and a simultaneous 40% decrease in torulene proportion. Higher cell mass was also achieved by double- and triple-strength fed-batch fermentation.
Effects of dietary fibre on behaviour and satiety in pigs (2008)

During the past decades there has been considerable interest in the use of dietary fibre in both animal and human nutrition. In human subjects dietary fibre has been studied intensively for possible effects on body-weight management and health. In animal nutrition the interest in dietary fibre has increased because it can be used as a cheap source of energy and because of its potential to improve animal welfare and reduce abnormal (mainly stereotypic) behaviour. Animal welfare is impaired if the diet does not provide sufficient satiety, combined with an environment that does not meet specific behavioural requirements related to natural feeding habits (e.g. rooting in pigs). A considerable proportion of the behavioural effects of dietary fibre are thought to be related to reduced feeding motivation. It has been hypothesized that: (1) bulky fibres increase satiety and thereby decrease physical activity and stereotypic behaviours immediately following a meal in pigs; (2) fermentable fibres prolong postprandial satiety and thereby reduce physical activity and appetitive behaviours for many hours after a meal. The validity of these hypotheses is examined by considering published data. In sows dietary fibres (irrespective of source) reduce stereotypic self-directed behaviours and substrate-directed behaviours, and to a lesser extent overall physical activity, indicating enhanced satiety shortly after a meal. Furthermore, fermentable dietary fibre reduces substrate-directed behaviour in sows and physical activity in sows and growing pigs for many hours after a meal. Evidence of long-term effects of poorly-fermentable fibre sources is inconclusive. The findings suggest that highly-fermentable dietary fibres have a higher potential to prolong postprandial satiety.
Applications of Modern Programming Language Concept to Text Processing with a Large Charakter Set. (1983)

In retinal microsurgery, membrane peeling is a standard procedure requiring the delamination of a thin fibrous membrane adherent to the retina surface by applying very small forces. Robotic devices with combined force-sensing instruments have significant potential to assist this procedure by facilitating membrane delamination through induced micro-vibrations. However, defining the optimal frequency and amplitude for generating such vibrations, and updating these parameters during the procedure is not trivial. Automatic adjustment of these parameters via an adaptive control scheme is possible only if the individual parameter effects on delamination behavior are known. This study presents an experimental exploration of how micro-vibration amplitude and frequency affect membrane peeling forces alone. Combining a micromanipulator and a force-sensing micro-forceps, several peeling experiments were done on artificial phantoms (bandages) and inner shell membrane of raw chicken eggs. In the tested range of micro-vibration frequencies (10-50 Hz) the average delamination force was minimized mostly at 30 Hz for the bandages and at 50 Hz for the egg membranes. Increasing the micro-vibration amplitude from 50 μm up to 150 μm provided further reduction in average force, thus facilitated membrane delamination.
Stability of <i>Candida albicans</i> allergens during storage (1992)

Stability of Candida albicans allergens was studied under various storage conditions. Lyophilized extract was reconstituted with human serum albumin (NSA) diluent, glycerol-free and in the presence of 10% or 50% glycerol and stored at various temperatures for different time periods. All extracts were tested at the same time with immunoblotting using C. albicans allergic patient sera and galactosidase-labelled anti-IgE. The highest number of detected allergens in the immunoblotting pattern was found in the presence of 50% glycerol at +6 degrees C. The most important allergen of C. albicans, the 46 kD protein allergen was stable up to 10 weeks at +6 degrees C in the presence of 50% glycerol but thereafter began to lose its IgE-binding capacity. After 30 weeks more than 50% of the IgE binding had disappeared. The 27 kD protein, another important allergen, was also labile but retained the allergenicity better than the 46 kD one. The 29 kD protein allergen was stable at all storage conditions, except +37 degrees C tested even after one year. More than 6 months storage at +6 degrees C or higher temperature is, however, unacceptable even in the presence of the 50% glycerol. These findings have particular importance in the diagnosis and treatment of allergic diseases.
Experience of VATs for posterior mediastinal neurogenic tumors (2012)

Objective To review the experience of video-assisted thoracoscopic resection for posterior mediastinal neurogenic tumors,to investigate the technical features and difficulties of thoracoscopic approach.Methods From May 2001 to June 2011,58 patients underwent thoracoscopic resection of posterior mediastinal tumors in our institution,including 36 males and 22 females.The average age of the patients was 38.7 years.The average tumor size was 4.9 cm.16 patients had neurogenic or pulmonary symptoms at the time of diagnosis,while the other 42 were asymptomic.24 lesions were located in the left side,33 lesions in the right side,1 lesion in bilateral sides.All procedures generally required 3 ports,and intracapsular enucleation was preferred,supplying vessels were ligated by hemoclips or Hem-o-lock clips; the nerves of origin were cut off at both edges of the tumor.For bulky tumor,dense adhesion,and massive bleeding,open conversions were performed by extending the incision anteriorly to 6-10 cm.Results All procedures were successfully performed without death event occurring.The average operating time was 127.2 min.The average intraoperative blood loss was 206.4 ml.3 cases requied blood transfusion.The average chest tube duration was 2.72 days.The average postoperative stay was 5.19 days.53 procedures were performed entirely under thoracoscopy to achieve gross-total resection.Conversions to an open procedure were necessitated in 5 patients (8.6％).7 patients experienced post-operative complications,with 4 Horner syndromes.There were 25 neurilemomas,23 neurofibromas,8 ganglioneuromas,1 paraganglioma,and 1 malignant paraganglioma.No local recurrence was seen after an average follow-up of 44.9 months.Conclusion Video-assisted thoracoscopic removes of the posterior mediastinal tumors are safe,reliable and minimally invasive for selected patients with mastered throcoscopic skills.intracapsular enucleation is a safe procedure with reduced risk,while tumors larger than 6cm and located in the apex are with increased risk.

Key words: 
Mediastinal neoplasms; Thoracoscopic surgery,video-assisted; Neuilemmama; NeurofibromaGanglioneuroma; Paraganglioma
Rapid infancy weight gain and subsequent obesity: Systematic reviews and hopeful suggestions (2006)

Rapid infancy weight gain is consistently associated with increased subsequent obesity risk, but the predictive ability of different weight gain cut-offs needs to be tested.
Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1 (2015)

The apolipoprotein L1 (APOL1) gene (APOL1) product is toxic to kidney cells, and its G1 and G2 alleles are strongly associated with increased risk for kidney disease progression in African Americans. Variable penetrance of the G1 and G2 risk alleles highlights the significance of additional factors that trigger or modify the progression of disease. In this regard, the effect of alternative splicing in the absence or presence of G1 or G2 alleles is unknown. In this study we investigated whether alternative splicing of non-G1, non-G2 APOL1 (APOL1 G0) affects its biological activity. Among seven APOL1 exons, exons 2 and 4 are differentially expressed in major transcripts. We found that, in contrast to APOL1 splice variants B3 or C, variants A and B1 demonstrate strong toxicity in human embryonic kidney (HEK293T) cells. Subsequently, we established that exon 4 is a major determinant of toxicity of variants A and B1 and that extracellular release of these variants is dispensable for their cytotoxicity. Although only variants A and B1 induced nuclear translocation of transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, exon 4-positive and -negative APOL1 variants stimulated perinuclear accumulation of unprocessed autophagosomes. Knockdown of endogenous TFEB did not attenuate APOL1 cytotoxicity, indicating that nuclear translocation of TFEB is dispensable for APOL1 toxicity. Our findings that a human podocyte cell line expresses exon 4-positive and -negative APOL1 transcripts suggest that these variants may play a differential role in podocyte pathology. In summary, we have identified exon 4 as a major determinant of APOL1 G0 cytotoxicity.
Evaluation of clock synchronization methods for measurement and control using embedded Linux SBCs (2012)

This paper reports a study and practical evaluation of two different clock synchronization methods for distributed measurement and control nodes based on Linux Single Board Computers (SBCs) with ARM processors and communicating through a TCP/IP wide area network. First the Network Time Protocol (NTP) is configured and evaluated in different network scenarios. The second solution is a specific development for Global Positioning System (GPS) clock synchronization. After a description of the hardware and software implementation of this solution the experimental results are reported and commented.
The Efflux Pump Inhibitor Reserpine Selects Multidrug-Resistant <i>Streptococcus pneumoniae</i> Strains That Overexpress the ABC Transporters PatA and PatB (2008)

One way to combat multidrug-resistant microorganisms is the use of efflux pump inhibitors (EPIs). Spontaneous mutants resistant to the EPI reserpine selected from Streptococcus pneumoniae NCTC 7465 and R6 at a frequency suggestive of a single mutational event were also multidrug resistant. No mutations in pmrA (which encodes the efflux protein PmrA) were detected, and the expression of pmrA was unaltered in all mutants. In the reserpine-resistant multidrug-resistant mutants, the overexpression of both patA and patB, which encode ABC transporters, was associated with accumulation of low concentrations of antibiotics and dyes. The addition of sodium orthovanadate, an inhibitor of ABC efflux pumps, or the insertional inactivation of either gene restored wild-type antibiotic susceptibility and wild-type levels of accumulation. Only when patA was insertionally inactivated were both multidrug resistance and reserpine resistance lost. Strains in which patA was insertionally inactivated grew significantly more slowly than the wild type. These data indicate that the overexpression of both patA and patB confers multidrug resistance in S. pneumoniae but that only patA is involved in reserpine resistance. The selection of reserpine-resistant multidrug-resistant pneumococci has implications for analogous systems in other bacteria or in cancer.
Elevated levels of interleukin-13 and IL-18 in patients with dengue hemorrhagic fever (2001)

Interleukin (IL)-13 is produced by T helper 2 (Th2)-type cells and inhibits the production of proinflammatory cytokines by activated monocytes, while IL-18 is a pleiotropic cytokine that induces interferon-γ and plays an important role in the development of Th1-type cells. Role of the shift from a Th1-type response to Th2-type has been suggested in the pathogenesis of dengue hemorrhagic fever (DHF). This study was undertaken to investigate the possible protective/pathogenic role of IL-13 and IL-18 in patients with DHF. Sera were collected from a total of 84 patients with various grades of dengue illness and 21 normal healthy controls and tested for IL-13 and IL-18 levels using commercial enzyme-linked immunosorbent assay kits. The results showed that very low levels of IL-13 (4±3 pg ml−1) and IL-18 (15±4 pg ml−1) were detected in the sera of healthy controls. In dengue patients, the levels of IL-13 and IL-18 were the highest in the patients with DHF grade IV (205±103 pg ml−1 and 366±155 pg ml−1, respectively) and the lowest in patients with dengue fever (22±12 pg ml−1 and 76±50 pg ml−1, respectively). Both the cytokines appeared (IL-13=20±11 pg ml−1 and IL-18=70±45 pg ml−1) during the first 4 days of illness and reached peak levels (IL-13=204±96 pg ml−1 and IL-18=360±148 pg ml−1) by day 9 onwards. The presence of high levels of IL-13 and IL-18 during severe illness and late phases of the disease suggests that both of these cytokines may contribute to the shift from a Th1- to Th2-type response and thus to the pathogenesis of DHF.
UM ESBOÇO DE UMA PERSONALIDADE MÍSTICA - DOI 10.5752/P.1983-2478.2014v10n17p13 (2015)

ResumoA intenção deste artigo é fazer um esboço do que seria uma personalidade mística portadora de uma ciência mística. Para tal, levantamos alguns instrumentos conceituais para este fim. Percorremos um breve histórico semântico da palavra “mística” no cristianismo. Em seguida, identificamos o que seria o elemento místico nas religiões, segundo o pesquisador Friedrich Von Hügel. Na sequência, analisamos os conceitos de exercícios espirituais do filósofo Pierre Hadot na filosofia antiga e de transcendentalismo (autoconfiança) no romantismo americano de Ralph Waldo Emerson, a fim de neles iluminar o que seria uma filosofia mística. Como último instrumento, vimos o conceito de aristocracia espiritual do filósofo russo Nicolai Berdiaev. Os principais traços dessa personalidade identificados são: ausência do problema de sentido da existência, enfrentamento da contingência, amor espontâneo pela vida, vontade autoconfiante, coragem, generosidade e atenção a presença da dimensão transcendente.Palavras-Chave: Mística. Cristianismo. Exercícios espirituais. Transcendentalismo. AbstractThis article intends to a make a sketch of what would be a mystical personality and its mystical science. In order to do so, we have identified some conceptual tools. First, we have followed a short history of the semantics of the word “mysticism” in Christianity. From there, we have moved onto Friedrich Von Hügel’s concept of mystical element, Pierre Hadot’s spiritual exercises in ancient philosophy, Ralph Waldo Emerson’s transcendentalism (self reliance), and, last, but not least, Nicolai Berdiaev’s concept of spiritual aristocracy. The main traits of the mystical personality we have identified are: lack of fear concerning the problem of meaning life, facing of contingence, spontaneuos love for life, self reliance, courage, generosity and atention to the transcendent dimension.Key words: Mysticism. Christianity. Spiritual exercises.Transcendentalism.
Impact of Polarisation Dependent Loss on Coherent POLMUX-NRZ-DQPSK (2008)

We present simulations and measurements on the effect of PDL on a POLMUX-NRZ- DQPSK signal. We show that the orientation between the POLMUX signal and PDL element has a major impact on the OSNR performance.
Corner detection in textured color images (1999)

Corner models in the literature have lagged behind edge models with respect to color and shading. We use both a region model, based on distributions of pixel colors, and an edge model, which removes false positives, to perform corner detection on color images whose regions contain texture. We show results on a variety of natural images at different scales that highlight the problems that occur when boundaries between regions have curvature.
A temperature and process insensitive CMOS reference current generator (2013)

This work presents a temperature and process insensitive CMOS transistor only reference current generator. In the proposed scheme, the passive resistor used in the CMOS Widlar current source is replaced with a transistor resistor where the gate voltage is controlled so that the output current is insensitive to temperature variation. Furthermore, to maintain the temperature insensitivity under process variations, the transistor resistor gate bias circuits optimized for nominal, strong and weak process corners are built on-chip. The proposed reference current generator is designed using 0.5 μm CMOS SOI technology, where the operation is verified through circuit level simulations under nine different process corners. The 20 μA reference current shows a temperature coefficient of 39 ppm/°C within the temperature range of 25°C ~ 125°C for the nominal process corner.
Lung glutathione adaptive responses to cigarette smoke exposure (2011)

CS exposures evoke a powerful GSH adaptive response in the lung and systemically. These data suggests there may be a sensor that sets the ELF GSH adaptive response to prevent GSH levels from dipping below basal levels. Factors that disrupt GSH adaptive responses may contribute to the pathophysiology of COPD.
Effect of Selective Serotonin Reuptake Inhibitors on the Risk of Fracture (2007)

Daily SSRI use in adults 50 years and older remained associated with a 2-fold increased risk of clinical fragility fracture after adjustment for potential covariates. Depression and fragility fractures are common in this age group, and the elevated risk attributed to daily SSRI use may have important public health consequences.
Bactericidal activity of biomimetic diamond nanocone surfaces (2016)

The formation of biofilms on implant surfaces and the subsequent development of medical device-associated infections are difficult to resolve and can cause considerable morbidity to the patient. Over the past decade, there has been growing recognition that physical cues, such as surface topography, can regulate biological responses and possess bactericidal activity. In this study, diamond nanocone-patterned surfaces, representing biomimetic analogs of the naturally bactericidal cicada fly wing, were fabricated using microwave plasma chemical vapor deposition, followed by bias-assisted reactive ion etching. Two structurally distinct nanocone surfaces were produced, characterized, and the bactericidal ability examined. The sharp diamond nanocone features were found to have bactericidal capabilities with the surface possessing the more varying cone dimension, nonuniform array, and decreased density, showing enhanced bactericidal ability over the more uniform, highly dense nanocone surface. Future research will focus on using the fabrication process to tailor surface nanotopographies on clinically relevant materials that promote both effective killing of a broader range of microorganisms and the desired mammalian cell response. This study serves to introduce a technology that may launch a new and innovative direction in the design of biomaterials with capacity to reduce the risk of medical device-associated infections.
System requirements for OFDM polar transmitter (2006)

The key requirements for an OFDM polar transmitter complying to IEEE 802.11a standard are studied at circuit block level. A system level simulator Agilent-ADS is used to model the transmitter with various impairments. The effects of different nonidealities are studied separately with respect to error vector magnitude and conformance to transmit mask. A reasonable set of block specification is given and its compliance to the standard is verified.
5‐Aza‐2'‐deoxycytidine reactivates gene expression <i>via</i> degradation of pRb pocket proteins (2011)

Not only does 5-aza-2'-deoxycytidine (5-aza-CdR) induce the reexpression of silenced genes through the demethylation of CpG islands, but it increases the expression of unmethylated genes. However, the mechanism by which 5-aza-CdR activates the expression of genes is not completely understood. Here, we report that the pRb pocket proteins pRb, p107, and p130 were degraded in various cancer cell lines in response to 5-aza-CdR treatment, and this effect was dependent on the proteasome pathway. Mouse double minute 2 (MDM2) played a critical role in this 5-aza-CdR-induced degradation of pRb. Furthermore, PP2A phosphatase-induced MDM2 dephosphorylation at S260 was found to be essential for MDM2 binding to pRb in the presence of 5-aza-CdR. pRb degradation resulted in the significant reexpression of several genes, including methylated CDKN2A, RASFF1A, and unmethylated CDKN2D. Finally, knockdown of pRb pocket proteins by either RNAi or 5-aza-CdR treatment induced a significant decrease in the recruitment of SUV39H1 and an increase in the enrichment of KDM3B and KDM4A to histones around the promoter of RASFF1A and thus reduced H3K9 di- and trimethylation, by which RASFF1A expression is activated. Our data reveal a novel mechanism by which 5-aza-CdR induces the expression of both methylated and unmethylated genes by degrading pRb pocket proteins.