gebhart/patrepeval huggingface dataset:
Energy-Aware High Resolution Image Acquisition via Heterogeneous Image Sensors (2008)

We present an energy-efficient high resolution image acquisition approach based on a two-tiered system comprising low-cost, low-power, non-actuated, extremely resource-constrained stereo image sensor platforms and more capable but more power-consumptive high resolution imaging platforms with actuation capability. The resource constrained platforms are used to compute 3D object location and subsequently to compute appropriate pan/tilt/zoom settings for the high resolution imaging platforms. The high resolution imaging platforms with actuation capability acquire high resolution images which can be utilized for various recognition purposes. We present a design methodology and system architecture, and evaluate latency and energy tradeoffs in the system. Experimental results show that use of the two-tiered network significantly reduces energy consumption of high resolution image acquisition versus a single-tiered network with minimum loss in detection capability.
CD4+CD25+ Regulatory T Cells in Patients with Acute Lymphocytic Leukemia. (2007)

Abstract Human CD4+CD25+ regulatory T (Treg) cells suppress antigen-specific T cell immune response and contribute to peripheral tolerance. However, little is known about the role of Treg cells in the pathogenesis of acute lymphocytic leukemia (ALL). In this study, the proportion of CD4+CD25+ Treg cells in the peripheral blood of three groups of people [the patients with ALL who had never received any chemotherapy before, the patients with ALL who had achieved partial remission (PR) or complete remission (CR) after chemotherapy and the healthy donors] was evaluated by flow cytometry. The expression level of Foxp3 mRNA of each group was examined by real-time RT-PCR. In vitro, the peripheral blood mononuclear cells (PBMC) from healthy donors were cultured in the serum of ALL patients without chemotherapy; each group was divided into sub-groups according to various serum doses. After co-cultured for 72 hours, the cells of all the groups were harvested separately and further tested the number of CD4+CD25+ Treg cells and the mRNA expression of Foxp3. The results showed that both the percentage of CD4+CD25+ T cells and the mRNA expression level of Foxp3 in patients with chemotherapy were significantly higher than those of the healthy donors and patients without chemotherapy (P<0.01 and P<0.01). Although the population of CD4+CD25+ T cells in ALL patients without chemotherapy was almost the same to that in the healthy donors (P>0.05), the expression of Foxp3 mRNA in former was higher (P<0.05) .The serum derived from ALL patients without chemotherapy remarkably increased the proportion of CD4+CD25+ T cells and the expression level of Foxp3 mRNA in co-cultured system, both of which were statistically higher than those in controls (P<0.05 and P<0.01) and did not vary with the serum dose. These results suggest that the chemotherapy may exert an influence on the production of CD4+CD25+ Treg cells and CD4+CD25+ Treg cells may play an important role in the pathogenesis of ALL.
Protein Kinase C Involvement in the Regulation of Angiogenesis (1993)

Using the chick chorioallantoic membrane as a model system for the study of angiogenesis, we have shown that promoters of protein kinase C (PKC) such as 4-beta-phorbol-12-myristate-13-acetate (4-beta-PMA) and 1,2-dioctanoyl-sn-glycerol (DiC8) stimulated angiogenesis. This effect was specific since 4-alpha-PMA and 1,2-dioleoyl-sn-glycerol, which either do not activate or cannot reach PKC, were devoid of angiogenic activity. Furthermore, Ro 31-8220, a specific inhibitor of PKC, suppressed both basal and 4-beta-PMA- or DiC8-induced angiogenesis. Similar results were obtained with the commonly used inhibitor of PKC, 1-(5-isoquinoline-sulfonyl)-2-methylpiperazine and with tricyclodecan-9-yl-xanthogenate, an antitumor agent which has been suggested to be an inhibitor of PKC. Activation of PKC may be, therefore, an important signalling pathway in the initiation and control of the angiogenic response.
Social Network Analysis on Name Disambiguation and More (2008)

Name variants are ubiquitous in real world due typographical errors (e.g., "Forschungszentrum Julich" vs. "Forschungszentrum Julich"), abbreviated, imcomplete, or missing information (e.g., "R. E. Ellis" vs. "Randy E. Ellis"), lack of standard name formatting convention (e.g., "Spike Jonze" vs. "Jones, Spike"), and their combinations. In this paper, we project this name disambiguation problem to graph representation, and then analyze graphs using social network analysis. In particular, we used real duplicate name entities that we manually verifed from ACM digital library. Then, using various string similarity metrics and additional information (i.e., co-author names, titles, and venues), we analyze the effectiveness of string similarity metrics and additional information based on social network analysis. Through our experimental validation, name disambiguation problem can be analyzed in graphical, visual manner.
Comparative drug screening in NUT midline carcinoma (2014)

These results demonstrate that FP may be of benefit to a subset of patients with NMC, and warrant a continued emphasis on microtubule inhibitors, anthracyclines, and topoisomerase inhibitors as effective drug classes in this disease.
Defect and Linker Effects on the Binding of Organophosphorous Compounds in UiO-66 and Rare-Earth MOFs (2018)

The adsorption of chemical warfare agents and their simulants by Zr (UiO-66) and rare-earth (Y, UiO-66-DOBDC analog)-based metal–organic frameworks (MOFs) is explored here using density functional theory. In particular, we investigate the role of linker functional group (OH, H) and metal atom identity on the binding energies of organophosphorous compounds. Commonly used cluster approximations for MOF secondary building units and various optimization constraints are compared with three-dimensional periodic results. An in-depth scan of potential binding sites and orientations reveals little effect due to metal identity, whereas the effect of linker functionalization depends on the substrate. This finding strongly suggests that full linkers and functional groups should be included in cluster models. Importantly, defect sites show considerably improved binding of organophosphorous compounds as compared to ideal clusters. Favorable binding is also demonstrated at two additional adsorption sites, ZrOH and μ3-OH, that likely play a role in the initial adsorption process. The results presented here portray the importance of including full three-dimensional pore structures in the adsorption process of organophosphorous compounds in MOFs; a critical first step in the degradation of these harmful chemicals.
Eigenvoice based fast speaker adaptation with bias compensation (2003)

In this paper, we propose the bias compensation methods to improve the performance of rapid speaker adaptation based on eigenvoice. Experimental results for vocabulary-independent word recognition task shows the proposed method yields improvements for a small adaptation data. We obtained 22/spl sim/30 % relative improvement by the bias compensation methods.
Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis (2002)

Group B coxsackieviral (CVB) infection commonly causes viral myocarditis. Mice are protected from CVB3 myocarditis by gene-targeted knockout of p56Lck(Lck), the Src family kinase (Src) essential for T cell activation. Extracellular signal-regulated kinase 1 and 2 (ERK-1/2) can influence cell function downstream of Lck. Using T cell lines and neonatal cardiac myocytes we investigated the role of ERK-1/2 in CVB3 infection. In Jurkat T cells ERK-1/2 is rapidly activated by CVB3; but, this response is absent in Lck-negative JCaM T cells. Inhibition of ERK-1/2 with UO126 reduced CVB3 titers in Jurkat cells, but not in JCaM cells. In cardiac myocytes CVB3 activation of ERK-1/2 is blocked by the Src inhibitor PP2. In addition, viral production in myocytes is decreased by Src or ERK-1/2 inhibition. In vitro, in both immune and myocardial cells, ERK-1/2 is activated by CVB3 downstream of Lck and other Src's and is necessary for efficient CVB3 replication. In vivo, following CVB3 infection, ERK-1/2 activation is evident in the myocardium. ERK-1/2 activation is intense in the hearts of myocarditis-susceptible A/J mice. In contrast, significantly less ERK-1/2 activation is found in the hearts of myocarditis-resistant C57BL/6 mice. Therefore, the ERK-1/2 response to CVB3 infection may contribute to differential host susceptibility to viral myocarditis.
Coaggregates of Regulatory T Cells and Islet Cells Allow Long-term Graft Survival in Liver Without Immunosuppression (2015)

The Treg cells and islet cells were distributed randomly in the coaggregates. After intraportal transplantation of the coaggregates, Treg cells in the aggregates enabled the long-term survival of allogeneic islet cell grafts in the liver without the use of immunosuppressive drugs.
Present Status of Lyme Borreliosis and Characterization of Lyme Disease Borrelia Isolated in Japan (1997)

Lyme disease is a multisystemic disorder caused by infection with Borrelia burgdorferi sensu lato which is carried by ticks of the Ixodes ricinus complex. The agent was discovered in 1982 in North America and the disease is recognized as an emerging infectious diseases in North America and Europe. Japanese Borrelia isolates were characterized by genetic and immunologic analysis. Isolates from Ixodes ovatus were found to be unique by DNA/DNA hybridization analysis, restriction fragment length polymorphism analyses of the flagellin gene and the 16S rRNA genes, and were described as new species, Borrelia japonica. Isolates from Ixodes persulcatus were determined as Borrelia garinii and Borrelia afzelii. However, B. garinii found in Japan was different from those from Europe in immunologic and genetic characteristics of outer surface protein A, but B. afzelii isolates from Japan and Europe were identical. An experimental model of arthritis related to Lyme disease using outbred ddY mice was established. Whole cell vaccine prepared from North American and European isolates could not elicit protective immunity against infection of Japanese isolates. This implies that vaccine development using Japanese isolates is necessary. Borrelia bound specifically to galactosylceramide (GalCer), glucosylceramide and lactosylceramide which are present in various types of cells as binding receptor, but not to other glycosphingolipids. Furthermore, the infectivity of Borrelia may be associated with the binding to glycosphingolipids on the cell surface and a 67 kilodalton protein of Lyme disease Borrelia may be involved in binding of Borrelia to GalCer.
Defects in embryonic hindbrain development and fetal resorption resulting from vitamin A deficiency in the rat are prevented by feeding pharmacological levels of all- <i>trans-</i> retinoic acid (1998)

Vitamin A is required for reproduction and normal embryonic development. We have determined that all-trans-retinoic acid (atRA) can support development of the mammalian embryo to parturition in vitamin A-deficient (VAD) rats. At embryonic day (E) 0.5, VAD dams were fed purified diets containing either 12 micrograms of atRA per g of diet (230 micrograms per rat per day) or 250 micrograms of atRA per g of diet (4.5 mg per rat per day) or were fed the purified diet supplemented with a source of retinol (100 units of retinyl palmitate per day). An additional group was fed both 250 micrograms of atRA per g of diet in combination with retinyl palmitate. Embryonic survival to E12.5 was similar for all groups. However, embryonic development in the group fed 12 micrograms of atRA per g of diet was grossly abnormal. The most notable defects were in the region of the hindbrain, which included a loss of posterior cranial nerves (IX, X, XI, and XII) and postotic pharyngeal arches as well as the presence of ectopic otic vesicles and a swollen anterior cardinal vein. All embryonic abnormalities at E12.5 were prevented by feeding pharmacological amounts of atRA (250 micrograms/g diet) or by supplementation with retinyl palmitate. Embryos from VAD dams receiving 12 micrograms of atRA per g of diet were resorbed by E18.5, whereas those in the group fed 250 micrograms of atRA per g of diet survived to parturition but died shortly thereafter. Equivalent results were obtained by using commercial grade atRA or atRA that had been purified to eliminate any potential contamination by neutral retinoids, such as retinol. Thus, 250 micrograms of atRA per g of diet fed to VAD dams (approximately 4.5 mg per rat per day) can prevent the death of embryos at midgestation and prevents the early embryonic abnormalities that arise when VAD dams are fed insufficient amounts of atRA.
Cold Object Identification in the Java Virtual Machine (2015)

Many Java applications instantiate objects within the Java heap that are persistent but seldom if ever referenced by the application. Examples include strings, such as error messages, and collections of value objects that are preloaded for fast access but they may include objects that are seldom referenced. This paper describes a stack-based framework for detecting these "cold" objects at runtime, with a view to marshaling and sequestering them in designated regions of the heap where they may be preferentially paged out to a backing store, thereby freeing physical memory pages for occupation by more active objects. Furthermore, we evaluate the correctness and efficiency of stack-based approach with an Access Barrier. The experimental results from a series of SPECjvm2008 benchmarks are presented.
Quantitative ultrasound method to detect and monitor laser-induced cavitation bubbles (2008)

An ultrasound technique to measure the spatial and temporal behavior of the laser-induced cavitation bubble is introduced. The cavitation bubbles were formed in water and in gels using a nanosecond pulsed Nd:YAG laser operating at 532 nm. A focused, single-element, 25-MHz ultrasound transducer was employed both to detect the acoustic emission generated by plasma expansion and to acoustically probe the bubble at different stages of its evolution. The arrival time of the passive acoustic emission was used to estimate the location of the cavitation bubble's origin and the time of flight of the ultrasound pulse-echo signal was used to define its spatial extent. The results of ultrasound estimations of the bubble size were compared and found to be in agreement with both the direct optical measurements of the stationary bubble and the theoretical estimates of bubble dynamics derived from the well-known Rayleigh model of a cavity collapse. The results of this study indicate that the proposed quantitative ultrasound technique, capable of detecting and accurately measuring laser-induced cavitation bubbles in water and in a tissue-like medium, could be used in various biomedical and clinical applications.
Acceleration of Amyloid β-Peptide Aggregation by Physiological Concentrations of Calcium (2006)

Alzheimer disease is characterized by the accumulation of aggregated amyloid beta-peptide (Abeta) in the brain. The physiological mechanisms and factors that predispose to Abeta aggregation and deposition are not well understood. In this report, we show that calcium can predispose to Abeta aggregation and fibril formation. Calcium increased the aggregation of early forming protofibrillar structures and markedly increased conversion of protofibrils to mature amyloid fibrils. This occurred at levels 20-fold below the calcium concentration in the extracellular space of the brain, the site at which amyloid plaque deposition occurs. In the absence of calcium, protofibrils can remain stable in vitro for several days. Using this approach, we directly compared the neurotoxicity of protofibrils and mature amyloid fibrils and demonstrate that both species are inherently toxic to neurons in culture. Thus, calcium may be an important predisposing factor for Abeta aggregation and toxicity. The high extracellular concentration of calcium in the brain, together with impaired intraneuronal calcium regulation in the aging brain and Alzheimer disease, may play an important role in the onset of amyloid-related pathology.
The effects of aging and cognitive decrements on simulated driving performance (2005)

Thesis (Ph.D.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Psychology
Perturbation analysis and modeling of curved microstrip bends (1990)

The curved microstrip bend consisting of a microstrip ring segment between two microstrip lines is analyzed for its transmission properties. The microstrip lines are modeled by equivalent ideal magnetic wall waveguides for which the electromagnetic field solutions are known. The field solutions in the microstrip ring segment are derived by using a perturbation analysis of a modified (magnetic wall) curved waveguide model. Other techniques have been formulated to evaluate the fields inside curved metallic waveguides. These include the use of an equivalent nonuniformly loaded straight waveguide and rectangular and annular model analysis. The perturbation solution for the fields in the equivalent curved waveguide model presented is readily adaptable to the mode-matching procedure, and is used to calculate the properties of the curved microstrip bend discontinuities. The frequency-dependent reflection and transmission coefficients of curved microstrip bends are determined and compared with those of the right-angle and chamfered right-angle microstrip bends.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Tenascin promotes cerebellar granule cell migration and neurite outgrowth by different domains in the fibronectin type III repeats. (1992)

The extracellular matrix molecule tenascin has been implicated in neuron-glia recognition in the developing central and peripheral nervous system and in regeneration. In this study, its role in Bergmann glial process-mediated neuronal migration was assayed in vitro using tissue explants of the early postnatal mouse cerebellar cortex. Of the five mAbs reacting with nonoverlapping epitopes on tenascin, mAbs J1/tn1, J1/tn4, and J1/tn5, but not mAbs J1/tn2 and J1/tn3 inhibited granule cell migration. Localization of the immunoreactive domains by EM of rotary shadowed tenascin molecules revealed that the mAbs J1/tn4 and J1/tn5, like the previously described J1/tn1 antibody, bound between the third and fifth fibronectin type III homologous repeats and mAb J1/tn3 bound between the third and fifth EGF-like repeats. mAb J1/tn2 had previously been found to react between fibronectin type III homologous repeats 10 and 11 of the mouse molecule (Lochter, A., L. Vaughan, A. Kaplony, A. Prochiantz, M. Schachner, and A. Faissner. 1991. J. Cell Biol. 113:1159-1171). When postnatal granule cell neurons were cultured on tenascin adsorbed to polyornithine, both the percentage of neurite-bearing cells and the length of outgrowing neurites were increased when compared to neurons growing on polyornithine alone. This neurite outgrowth promoting effect of tenascin was abolished only by mAb J1/tn2 or tenascin added to the culture medium in soluble form. The other antibodies did not modify the stimulatory or inhibitory effects of the molecule. These observations indicate that tenascin influences neurite outgrowth and migration of cerebellar granule cells by different domains in the fibronectin type III homologous repeats.
SNITCH: AUGMENTING HYPERTEXT DOCUMENTS WITH A SEMANTIC NET (1993)

A new model of hypertext, in which text is augmented with a fine-grained semantic net representation of the text, solves several problems found in traditional hypertext models. In the new model, hypertext links are paths that originate in the text, move across to the semantic net, traverse a sub-path through the semantic net, then return to a different point in the text. Benefits of the model include a strong semantics for links, dynamic discovery of links, link reusability, and automatic creation of links. The SNITCH hypertext system, which is based on this model, allows a user to access data in ways never foreseen by the hypertext author.
Algorithmic Cartography (2015)

We study the problem of selecting a set of points of interest (POIs) to show on a map. We begin with a formal model of the setting, noting that the utility of a POI may be discounted by (i) the presence of competing businesses nearby as well as (ii) its position in the set of establishments ordered by distance from the user. We present simple, approximately optimal selection algorithms, coupled with incentive compatible pricing schemes in case of advertiser supplied points of interest. Finally, we evaluate our algorithms on real data sets and show that they outperform simple baselines.
HLA compatibility and organ transplant survival. Collaborative Transplant Study. (1999)

The influence of HLA compatibility on organ transplant survival was analyzed in more than 150,000 recipients transplanted from 1987 to 1997 at transplant centers participating in the Collaborative Transplant Study. A statistically highly significant effect of HLA matching on graft and patient survival rates was found in the analysis of kidney transplants (P < 0.0001). Ten years after transplantation, the graft survival rate of first cadaver kidney transplants with a complete mismatch (6 HLA-A+B+DR mismatches) was 17% lower than that of grafts with no mismatch. During the first post-transplant year, the class II HLA-DR locus had a stronger impact than the class I HLA-A and HLA-B loci. During subsequent years, however, the influence on graft survival of the three loci was found to be equivalent and additive. For optimal graft outcome, compatibility at all three HLA loci is, therefore, desirable. The excellent correlation of HLA matching observed in recipients of cadaver kidneys with very short ischemic preservation (0-6 hours) or recipients of kidneys from living unrelated donors contradicts reports that short ischemia can eliminate the influence of matching. Although HLA has a significant effect on graft outcome regardless of the state of presensitization, the matching effect is potentiated in patients with highly reactive preformed lymphocytotoxic antibodies. Among first cadaver transplant recipients with an antibody reactivity against > 50% of the test panel, the difference in graft survival at 5 years between patients with 0 or 6 mismatches reached 30%. A collaborative project, in which molecular DNA typing methods were employed, showed that the correction of serological HLA typing errors by more accurate DNA typing results in a significantly improved HLA matching effect. Moreover, matching for the class II locus HLA-DP, a locus that can be typed reliably only by DNA methods, showed a significant effect in cadaver kidney retransplants, especially in the presence of preformed lymphocytotoxic antibodies. The analysis of heart transplants showed a highly significant impact of HLA compatibility on graft outcome (P < 0.0001). This result is of particular interest because donor hearts are not allocated according to the HLA match. A biasing influence of donor organ allocation (i.e. a preferential allocation of good matches to good risk recipients) can, therefore, be excluded. In liver transplantation, neither matching for HLA class I nor HLA class II could be shown to influence transplant outcome.