gebhart/patrepeval huggingface dataset:
O-Antigen modifications providing antigenic diversity of Shigella flexneri and underlying genetic mechanisms (2015)

O-Antigens (O-specific polysaccharides) of Shigella flexneri, a primary cause of shigellosis, are distinguished by a wide diversity of chemical modifications following the oligosaccharide O-unit assembly. The present review is devoted to structural, serological, and genetic aspects of these modifications, including O-acetylation and phosphorylation with phosphoethanolamine that have been identified recently. The modifications confer the host with specific immunodeterminants (O-factors or O-antigen epitopes), which accounts for the antigenic diversity of S. flexneri considered as a virulence factor of the pathogen. Totally, 30 O-antigen variants have been recognized in these bacteria, the corresponding O-factors characterized using specific antibodies, and a significant extension of the serotyping scheme of S. flexneri on this basis is suggested. Multiple genes responsible for the O-antigen modifications and the resultant serotype conversions of S. flexneri have been identified. The genetic mechanisms of the O-antigen diversification by acquisition of mobile genetic elements, including prophages and plasmids, followed occasionally by gene mobilization and inactivation have been revealed. These findings further our understanding of the genetics and antigenicity of S. flexneri and assist control of shigellosis.
A First-in-Human Study of Conatumumab in Adult Patients with Advanced Solid Tumors (2010)

Conatumumab can be administered safely up to the target dose of 20 mg/kg every 2 weeks.
The evolution of DVI system software (1992)

article Free Access Share on The evolution of DVI system software Author: James L. Green Intel's Multimedia Products Operation, Princeton, NJ Intel's Multimedia Products Operation, Princeton, NJView Profile Authors Info & Claims Communications of the ACMVolume 35Issue 1Jan. 1992 pp 52–67https://doi.org/10.1145/129617.129619Published:02 January 1992Publication History 23citation559DownloadsMetricsTotal Citations23Total Downloads559Last 12 Months26Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Clinical and microbiological effects of <i>Lactobacillus reuteri</i> probiotics in the treatment of chronic periodontitis: a randomized placebo‐controlled study (2013)

The results indicate that oral administration of L. reuteri lozenges could be a useful adjunct to SRP in chronic periodontitis.
Object-driven image group annotation (2010)

In this paper, we propose a three-stage method for annotating image groups in real-world photo image databases: (1) Image databases are automatically divided into several image groups so that most photos in each group were taken in the same scene using the time information associated with each photo; (2) Objects in each image are recognized using multiclass object recognition; (3) Each image group is categorized into a scene using all object labels from (2) in the image group. Our main contribution is to propose a novel method for annotating image groups using all objects recognized from all images in this image group. We train our method on 6,000 objects in 696 images from the LabelMe dataset and verify the effectiveness of our proposed method on real-world photo databases consists of 4 outdoor scenes.
Angiotensin II antagonists—saralasin (1984)

Abstract Saralasin is the only marketed member of a class of compounds described as angiotensin II receptor antagonists. Its pharmacology is characterized by three general properties: (1) no actions unrelated to the renin‐angiotensin system; (2) a small partial agonist effect in some tissues in vitro and in some animal models in vivo, and (3) a blood‐pressure lowering response to saralasin evident only in animals with an activated endogenous renin angiotensin system. It is suggested that the natriuretic effect of angiotensin II mediated via central nervous system (CNS) mechanisms may be future productive area of research in which to study the actions of angiotensin II antagonists.
OS Support for Virtualizing Hardware Transactional Memory (2008)

Transactional memory promises to simplify multithreaded\nprogramming. Hardware TM (HTM) implementations promise better\nperformance by augmenting processors with transactional\nstate. However, HTMs interact poorly with the operating system or\nvirtual machine monitor. For example, they often do not tolerate OS\nactions that virtualize processors and memory, such as context\nswitching and paging. Without support for these actions, an HTM may\nnot execute programs correctly or guarantee forward progress.\n\nWe investigate virtualizing transactional memory in the context of\nLogTM-SE. First, we describe an implementation of a kernel module in\nOpenSolaris that implements transactional virtualization and requires\nonly 1120 lines of code. Second, we find that LogTM-SE interacts\npoorly with virtual machine monitors due to a reliance on physical\naddresses. We propose an extension to LogTM-SE, called LogTM-VSE, that\naddresses these problems and improves context-switching\nperformance. Third, through application tracing on real hardware and\nfull system simulation, we show virtualizing transactions can be\nnecessary for system stability and to support code that voluntarily\ncontext switches. However, we find that aborting a transaction is\ngenerally faster than virtualizing it, and hence preferable in some\ncases.
Thrombogenesis in experimental microvascular anastomosis (1979)

A large number of microvascular anastomoses, involving both arteriovenous and artery-artery end-to-side and end-to-end anastomoses, were carried out in the rat to develop a temporal and morphologic profile of thrombogenesis. While excellent patency rates were obtained in purely arterial preparations, significant thrombus formation occurred in the arteriovenous preparations, both at the suture line and more distally in the vein. Factors contributing to thrombogenesis in these microvascular anastomoses are discussed.
Solid-Phase Synthesis of Oligoribonucleotides Using 5′-9-Fluorenylmethoxycarbonyl and 2′-1-(Isopropoxyl)ethyl Protection (1991)

Abstract The 1-(isopropoxy)ethyl group (Ipe) has been employed for the protection of the 2′-hydroxy groups of ribonucleoside residues in the synthesis of oligoribonucleotides by the phosphoramidite approach on a solid support, using an base-labile 5′-9-fluorenylmethoxycarbonyl (Fmoc) group.
Isolation of Cells from the Feto-Maternal (2012)

The mucosal lining of the human uterus is host to a specialized population of leukocytes, which, during pregnancy, interact with invading placental cells (trophoblast) of fetal origin. Of particular interest are uterine natural killer cells, which account for around 70% of the leukocytes at this site during the first trimester of pregnancy, and seem to be specially adapted to recognize invading trophoblast cells. In order to understand the interactions between mucosal immune cells and trophoblast, and those among the immune cells themselves, it is useful to be able to isolate and culture these cells. Here, we describe protocols for the isolation of leukocytes, stromal cells, and trophoblast cells from the feto-maternal interface. Curr. Protoc. Immunol. 97:7.40.1-7.40.11. C
High-throughput isolation of ultra-pure plasmid DNA by a robotic system (2006)

Using this robot we demonstrate how centrifugation steps with multiple precipitations, most notably through a precipitation step of SDS in isopropanol, lead to high purity plasmid DNA and make possible high-throughput transfections into mammalian cells for functional gene annotations.
Endometriosis (2001)

Many doctors, both general practitioners and specialists, find endometriosis difficult to manage. Equally, many patients are dissatisfied with the care they receive. Endometriosis is the presence of endometrium at sites outside the endometrial cavity. It has long been known that the symptoms experienced by a patient may seem disproportionate to the extent of the disease observed within that patient's pelvis. For the patient it is not the endometriosis that is important but rather the illness that they experience. In this article I address the treatment of symptomatic endometriosis and infertility associated with the disease.
On the Impact of Integration of Non-Image Forming (NIF) Effect of Light on Electrical Lighting Control in Non-Residential Buildings (2016)

Lighting has an impact on the visual as well as cognitive performance of people in non-residential buildings. Light is the most powerful time cue for resetting the circadian pacemaker and ensuring correct synchronization of the internal clock with the environment: these effects are called âNon-Image Formingâ (NIF) functions. The expected neuroendocrine and neurobehavioral responses of subjects to light exposure can be summarized in four principal categories: alertness, sleep quality, mood and performance. The properties of light such as intensity, timing, pattern and light history influences neurobehavioral responses. These significant effects of light are currently not considered in building automation mainly due to the unknown and complicated nature of NIF effects as well as lack of proper technology. This leads likely to a considerable loss of productive time and momentum for the office occupants. This paper explores the existing knowledge of NIF effects of light on human beings and consequently proposes a novel dynamic lighting pattern, which is used as a set point for an integrated daylighting and electric lighting system. In other words, the existing scientific knowledge of NIF effect of light is introduced into the lighting engineering and automation domain. This user-centric approach allows for a system level study of the suggested variable lighting set points. A novel High Dynamic Range (HDR) vision sensor installed next to the office user allows for an âon-the-flyâ evaluation of the light flux received by the human eyes during daytime: it also offers a personalized, refined control of an integrated electric lighting and sun shading system.
Substrate-Specific Photocatalytic Activities of TiO<sub>2</sub> and Multiactivity Test for Water Treatment Application (2007)

The multidimensional aspects of the photocatalytic activity were investigated in a systematic way. The photocatalytic activities of eight commercial TiO2 samples were quantified by employing 19 test substrates (phenols, organic acids, amines, chlorohydrocarbons, dyes, inorganic ions, etc.) in terms of their degradation or conversion rates in water. The measured activities exhibited a complex behavior that depends on the test substrate. The photocatalytic activities are roughly correlated only among structurally related compounds. The photocatalytic activities can be represented in many different ways, and even the relative activity order among the tested photocatalysts depends on what substrate is used. Each TiO2 (among eight samples) showed the best activity for at least one test-substrate. This highly substrate-specific activity of TiO2 photocatalysts hinders the straightforward comparison of which catalyst is better than others. Even the common belief that anatase is more photoactive than rutile cannot be fully supported on the basis of the present data set. Although there seems to be no simple correlation between the activity and the common physicochemical parameters of photocatalysts, the substrate-specific activity was analyzed and discussed in terms of various parameters such as surface area, crystallinity, surface charge, and substrate adsorption. Finally, the multivalue photocatalytic activity test in relation with water treatment application was proposed to take the substrate-specificity into account.
SEDEA: State Estimation-Based Dynamic Encryption and Authentication in Smart Grid (2017)

A state estimation-based dynamic encryption and authentication (SEDEA) approach is proposed to protect the communication between the control center (CC) and remote terminal units (RTUs) in the smart grid, including the measurements reported from RTUs and the commands sent from the CC. The measurements of power systems are selected to generate encryption keys, which are measured on the RTUs, and estimated on CC using state estimation. With the changes of the power system, each RTU updates its key regularly, and the CC estimates the new keys of all RTUs dynamically and synchronously. The pairs of keys between the CC and each RTU are applied to ensure the confidentiality and integrity of their communication. The advantages of SEDEA could be summarized as follows. First, high security-the keys are difficult to predict and steal, since the power measurements, used to generate the keys, are constantly changing and unpredictable, and would never be exchanged in the network. Second, easy implementation-all measuring equipment on RTU and state estimation on the CC are the legacy of the current power system. And the encryption functions applied in SEDEA are simple and low cost for current devices in the power system, such as XOR, hash, and rounding. Thus, SEDEA is considered as a high-security, inherent and light-weight scheme for Smart Grid. In the experiments, we conduct SEDEA on the four-bus system to show the whole process step by step, including state estimation, key generation, and error correction. And the simulations on the IEEE 39-bus system to analyze the computation cost, error correction, and security of SEDEA.
A versatile acid-labile linker for antibody–drug conjugates (2014)

Silyl ether chemistry was used as the linker for an antibody drug conjugate to release a chemotherapeutic at low pH.
The methods of graphical statics and their relation to the structural form (2003)

In the preface of the 2nd edition of his main work «Die graphische Statik» ( 875), Karl Cu]mann was pleased to report that graphical statics had been taken up wide]y, but at the same time he complained that it was taught without the mathematica] base of the projective geometry. Subsequently, the «Graphostatik» (graphostatics), characterised by its recipe-like structure, became generally accepted. The graphostatics formed an essential means of intellectual engineering practice. It still referred to the unity of design, calculation and construction. Various examp]es demonstrate the option of deriving fram the graphical examination not only the interna] forces required for dimensioning, but a]so criteria for optimising the structura] formo Nevertheless, with the comp]etion of the classic structural theory after ] 890, the decline of the graphica] statics in favour of analytical calculation methods was a]ready becoming apparent. This corresponded with the desire to rationalise the engineer' s work, but it led to the disintegration of the unity of design, calcu]ation and construction. Today unlike in engineering practice, graphica] methods still play an important ra]e in ]ecturing on structures. The clarity of graphical techniques has a high didactic value, since interdependencies, e.g. between forces and structura] geometry, can be directly experienced visually. Architecture and structura] engineering students thus are provided with a suitable means of evaluating not least historie Rolf Gerhardt Karl-Eugen Kurrer Gerhard Pichler
Design of a Step-Down DC-DC Controller Integrated Circuit with Adaptive Dead-Time Control (2010)

A constant-frequency peak current mode synchronous step-down DC-DC controller integrated circuit has been designed with adaptive dead-time control. The adaptive dead-time control circuitry is implemented as digital delay-locked loop with digital counters as memory elements. In periodic steady state, the switch is controlled to turn on exactly when the body diode starts to conduct current. The conduction loss through MOSFET switch body diode is minimized. In spice simulation, this scheme increases the overall efficiency in low-voltage applications by up to 3%. VI-A Thesis Supervisor: Eric Gu Title: Design Engineer, Linear Technology Corporation Thesis Supervisor: David Perreault Title: Associate Professor
Ultra lightweight JavaScript engine for internet of things (2015)

The demonstration aims to present JerryScript, a JavaScript engine for the Internet of Things (IoT). This is a lightweight JavaScript engine intended to run on very constrained devices such as microcontrollers, which have only a few kilobytes of RAM available to the engine (<64 KB RAM) and constrained ROM space for the code of the engine (<200 KB ROM). The engine is ECMA-262 5.1 compliant, supports on-device compilation, execution, and provides access to peripherals from JavaScript. It powers the IoT.js project, which provides an interoperable service platform in the world of web-based IoT. This demonstration proves that usage of JavaScript on every constrained device is reasonable and profitable.
A Study of Depletion Layer Effects on Equivalent Circuit Parameters Using an Electrochemical Quartz Crystal Impedance System (1999)

An electrochemical quartz crystal impedance system (EQCIS) was used to investigate depletion layer effects on equivalent circuit parameters of piezoelectric quartz crystal resonance in electrochemical processes of CoSO4 aqueous solutions containing 0.4 mol/L ethylenediamine + 0.5 mol/L Na2SO4, 0.2 mol/L 1,10-phenanthroline + 0.5 mol/L Na2SO4 and K3Fe(CN)6, or K4Fe(CN)6 aqueous solutions containing 1.0 mol/L KCl in potential cycling experiments, respectively. The impedance data were analyzed according to Martin's model. For the former two systems, motional resistance R1, series resonant frequency fs, and motional inductance L1 changed reversibly with potential, and the observed values of ΔR1, ΔL1, and Δfs roughly satisfied equations reflecting liquid loading effects, suggesting that changes in these parameters might be mainly governed by local variations in solution density and viscosity near the electrode surface. For the latter two systems, reversible changes in R1 with potential coincided well with the simulated results from variations in solution density and viscosity near the electrode surface; however, besides reversible changes of ΔL1 and Δfs with potential, rising drifts of fs and decreasing drifts of L1 were found at oxidation potentials. The drifts of fs and L1 observed are believed to result from mass changes of the gold electrode, and cyanide and chloride corrosion of the gold electrode at oxidation potentials may play an important role for the drifting phenomena. It is concluded that quantitative analyses of ΔR1, ΔL1, and Δfs obtained from the EQCIS provide the possibility for differentiating the net depletion layer effect with the change in electrode mass, and the ΔR1 response may be well used for evaluating local changes in liquid loading inside the depletion layer compared with responses of Δfs and ΔL1.
Potassium and massive blood transfusion. (1991)

Sixty patients who received massive blood transfusion intraoperatively and/or in the immediate post-operative period were analysed. Six patients had hypokalemia and two had hyperkalemia. The multifactorial changes leading to electrolyte disturbances especially involving potassium are discussed in relation to hypotension, hypothermia, acidosis, pH, and release of catecholamine. Potassium changes in relation to anaesthesia are discussed. The danger of routine administration of calcium during massive blood transfusion is stressed.
Breathing and Thinking: Unacknowledged Coronary Risk Factors (1987)

Health is a quality of life we enjoy when we can take a vigorous part in the world around us and yet keep the internal milieu in a balanced, orderly and stable condition. In varying degrees we are all vulnerable to loss of integrity of the internal self-regulating systems through such influences as the external environment's changing too fast for our adaptive mechanisms, loss of control, lack of sleep, inadequate supplies of energy and information for the tasks on hand, and a want of social assets.
Investigation of the Relaxation of Persistent Current in Superconducting Closed Loops Made Out of YBCO Coated Conductors (2014)

Coated conductors allow the fabrication of closed superconducting loops of arbitrary size. Various mechanisms can play a role in the decay of a persistent current in one such loop and in an assembly of multiple loops magnetically coupled with each other. We report recent experimental results on the relaxation rate of the persistent current in an assembly of closed superconducting loops made out of the currently manufactured coated conductors. One of the main goals of this study is to find the effective ways to control the relaxation rate so as to make it small enough to enable such high temperature persistent magnets to be considered as potential alternatives for energy storage, MRI magnets, and magnetic levitation applications. Here we report the effect of appropriately modified current sweep reversal method on the relaxation rate.
Leicht weit = Light structures : Jorg Schlaich, Rudolf Bergermann (2003)

When today's leading architects - such as Frank O. Gehry, Helmut Jahn and the THINK team - are looking for engineers to provide structural viability for their aesthetic visions, they often turn to Jorg Schlaich and his partner Rudolf Bergermann. The work of these brilliant and creative men is distinguished by a holistic approach combining science, practicality and meticulous attention to detail with environmental and situational concerns. This retrospective of their work highlights Schlaich and Bergermann's independent projects, including towers, bridges, wind farms and swimming pools. It features nine critical and biographical essays as well as detailed examinations of their most impressive work, illustrating a triumphant alliance of technical and architectural goals.
Prostaglandin E1 Improves Pulsatile Preservation Characteristics and Early Graft Function in Expanded Criteria Donor Kidneys (1998)

Unlike simple cold storage, machine preservation allows dynamic assessment and manipulation of the donor organ before transplantation. The effects of four pharmacologic agents added to the perfusate during machine preservation of expanded criteria donor (ECD) kidneys were prospectively compared to 1) describe their influence on perfusion parameters and 2) determine their influence on early graft outcome. Between 1 January 1995 and 1 October 1997, 125 consecutive ECD kidneys were preserved in the authors' laboratory. A definition of ECD was assigned to kidneys requiring pretransplant biopsy. The ECD kidneys were randomized to receive prostaglandin E1 (PGE1), trifluoperazine (TFP), verapamil (VER), mannitol (MAN), or no intervention (control) during machine preservation. All kidneys were preserved by continuous hypothermic pulsatile perfusion (CHPP) using Belzer II solution, and perfusion parameters were measured every 2 hours during pulsatile perfusion. The addition of PGE1 to the perfusate increased renal flow and decreased renal resistance. Moreover, the PGE1 treated group was associated with improved early graft function when compared with all other groups. The addition of VER, TFP, and MAN influenced neither the perfusion characteristics nor the incidence of early graft function. Treatment with PGE1 during machine preservation enhances hydrostatic perfusion parameters (renal flow and renal resistance) and reduces the incidence of delayed graft function in ECD kidneys.