gebhart/patrepeval huggingface dataset:
The Serum Protein α2-HS Glycoprotein/Fetuin Inhibits Apatite Formation in Vitro and in Mineralizing Calvaria Cells (1996)

We present data suggesting a function of alpha2-HS glycoproteins/fetuins in serum and in mineralization, namely interference with calcium salt precipitation. Fetuins occur in high serum concentration during fetal life. They accumulate in bones and teeth as a major fraction of noncollagenous bone proteins. The expression pattern in fetal mice confirms that fetuin is predominantly made in the liver and is accumulated in the mineralized matrix of bones. We arrived at a hypothesis on the molecular basis of fetuin function in bones using primary rat calvaria osteoblast cultures and salt precipitation assays. Our results indicate that fetuins inhibit apatite formation both in cell culture and in the test tube. This inhibitory effect is mediated by acidic amino acids clustering in cystatin-like domain D1. Fetuins account for roughly half of the capacity of serum to inhibit salt precipitation. We propose that fetuins inhibit phase separation in serum and modulate apatite formation during mineralization.
Classification of Fundus Autofluorescence Patterns in Early Age-Related Macular Disease (2005)

Various phenotypic patterns of abnormal FAF can be identified with cSLO imaging. Distinct patterns may reflect heterogeneity at a cellular and molecular level in contrast to a nonspecific aging process. The results indicate that the classification system yields a relatively high degree of intra- and interobserver agreement. It may be applicable for determination of novel prognostic determinants in longitudinal natural history studies, for identification of genetic risk factors, and for monitoring of future therapeutic interventions to slow the progression of early AMD.
Space-Time FSK: An Implicit Pilot Symbol Assisted Modulation Scheme (2007)

We develop in this paper an Alamouti-type space- time (ST) block code that employs orthogonal <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</i> -ary FSK (MFSK) modulation. It is demonstrated that every transmitted symbol in the proposed ST-MFSK scheme can be treated as an implicit pilot symbol, and consequently the receiver can attain close to ideal coherent bit-error performance even in the absence of an explicit channel sounding signal. In addition to employing the popular block-wise static fading model for performance evaluation, we also study the implications of a more realistic fading model whereby the fading gains are allowed to vary from one subinterval to another within a ST code block. It was discovered that an iterative channel estimation strategy has to be adopted to mitigate the cross-talk associated with this refined channel model. The iterative channel estimator, in conjunction with a companion minimum mean square error detector, or a companion maximum likelihood detector, enable the receiver to obtain a bit-error performance similar to that obtained under the block-wise static fading model. In comparison with differential ST-MPSK, the two approaches yield similar error performance in a static fading environment. However, the error performance of differential ST-MPSK deteriorates rapidly as the fade rate increases whereas the performance of ST-MFSK is almost independent of the fade rate. In terms of implementation complexity and delay of the receiver, the proposed coherent ST- MFSK scheme and differential ST-MPSK are very similar, as both approaches employ digital filters of similar lengths. The findings in this paper suggest that despite its larger bandwidth requirement, ST-MFSK is a very attractive alternative space-time signaling format.
The Fuzzy Correlation between Code and Performance Predictability (2005)

Recent studies have shown that most SPEC CPU2K benchmarks exhibit strong phase behavior, and the Cycles per Instruction (CPI) performance metric can be accurately predicted based on program's control-flow behavior, by simply observing the sequencing of the program counters, or extended instruction pointers (EIPs). One motivation of this paper is to see if server workloads also exhibit such phase behavior. In particular, can EIPs effectively predict CPI in server workloads? We propose using regression trees to measure the theoretical upper bound on the accuracy of predicting the CPI using EIPs, where accuracy is measure by the explained variance of CPI with EIPs. Our results show that for most server workloads and, surprisingly, even for CPU2K benchmarks, the accuracy of predicting CPI from EIPs varies widely. We classify the benchmarks into four quadrants based on their CPI variance and predictability of CPI using EIPs. Our results indicate that no single sampling technique can be broadly applied to a large class of applications. We propose a new methodology that selects the best-suited sampling technique to accurately capture the program behavior.
Extracellular Matrix-Regulated Gene Expression Requires Cooperation of SWI/SNF and \nTranscription Factors (2006)

Extracellular cues play crucial roles in the transcriptional regulation of tissue-specific genes, but whether and how these signals lead to chromatin remodeling is not understood and subject to debate. Using chromatin immunoprecipitation assays and mammary-specific genes as models, we show here that extracellular matrix molecules and prolactin cooperate to induce histone acetylation and binding of transcription factors and the SWI/SNF complex to the beta- and gamma-casein promoters. Introduction of a dominant negative Brg1, an ATPase subunit of SWI/SNF complex, significantly reduced both beta- and gamma-casein expression, suggesting that SWI/SNF-dependent chromatin remodeling is required for transcription of mammary-specific genes. Chromatin immunoprecipitation analyses demonstrated that the ATPase activity of SWI/SNF is necessary for recruitment of RNA transcriptional machinery, but not for binding of transcription factors or for histone acetylation. Co-immunoprecipitation analyses showed that the SWI/SNF complex is associated with STAT5, CCAAT/enhancer-binding protein beta, and glucocorticoid receptor. Thus, extracellular matrix- and prolactin-regulated transcription of the mammary-specific casein genes requires the concerted action of chromatin remodeling enzymes and transcription factors.
Shear and extensional rheological investigations in solutions of grafted and ungrafted polysaccharides (2000)

Many polysaccharides with varying shear stability have been grafted with polyacrylamide branches to enhance their turbulent drag-reducing and flocculating characteristics. Their aqueous solutions have been studied by shear and extensional rheometric techniques. All the solutions of grafted carboxymethyl cellulose, guar gum, starch, and sodium alginate exhibit shear-thinning non-Newtonian behavior. The viscosities are higher than those of ungrafted polysaccharides. The solutions of grafted carboxymethyl cellulose, guar gum and sodium alginate are spinnable. When subjected to uniaxial stretching in a stretching device, the formation of a thread and reduction of the thread diameter with time were observed. The stretching device was used to measure the relaxation time, which was found to be the largest (∼26 ms), on the order of flexible polyacrylamide, for the grafted carboxymethyl cellulose. Though a polyacrylamide solution degrades through nozzle flow and completely loses its extensional properties, a solution of grafted carboxymethyl cellulose retains about half its relaxation time because of the shear stability of polysaccharide chains and their structure. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 77: 3200–3209, 2000
Genes, Enzymes, and Regulation of <i>para</i> -Cresol Metabolism in <i>Geobacter metallireducens</i> (2007)

In aerobic and facultatively anaerobic bacteria, the degradation of para-cresol (p-cresol) involves the initial hydroxylation to p-hydroxybenzyl alcohol by water catalyzed by the soluble, periplasmatic flavocytochrome p-cresol methylhydroxylase (PCMH; alpha(2)beta(2) composition). In denitrifying bacteria the further metabolism proceeds via oxidation to p-hydroxybenzoate, the formation of p-hydroxybenzoyl-coenzyme A (CoA), and the subsequent dehydroxylation of the latter to benzoyl-CoA by reduction. In contrast, the strictly anaerobic Desulfobacterium cetonicum degrades p-cresol by addition to fumarate, yielding p-hydroxybenzylsuccinate. In this work, in vitro enzyme activity measurements revealed that the obligately anaerobic Geobacter metallireducens uses the p-cresol degradation pathway of denitrifying bacteria. Surprisingly, PCMH, which is supposed to catalyze both p-cresol hydroxylation and p-hydroxybenzyl alcohol oxidation to the corresponding aldehyde, was located in the membrane fraction. The alpha subunit of the enzyme was present in two isoforms, suggesting an alphaalpha'beta(2) composition. We propose that the unusual asymmetric architecture and the membrane association of PCMH might be important for alternative electron transfer routes to either cytochrome c (in the case of p-cresol oxidation) or to menaquinone (in the case of p-hydroxybenzyl alcohol oxidation). Unusual properties of further enzymes of p-cresol metabolism, p-hydroxybenzoate-CoA ligase, and p-hydroxybenzoyl-CoA reductase were identified and are discussed. A proteomic approach identified a gene cluster comprising most of the putative structural genes for enzymes involved in p-cresol metabolism (pcm genes). Reverse transcription-PCR studies revealed a different regulation of transcription of pcm genes and the corresponding enzyme activities, suggesting the presence of posttranscriptional regulatory elements.
Ultrathin Terahertz Quarter-wave plate based on Split Ring Resonator and Wire Grating hybrid Metasurface (2016)

Planar metasurface based quarter-wave plates offer various advantages over conventional waveplates in terms of compactness, flexibility and simple fabrication; however they offer very narrow bandwidth of operation. Here, we demonstrate a planar terahertz (THz) metasurface capable of linear to circular polarization conversion and vice versa in a wide frequency range. The proposed metasurface is based on horizontally connected split ring resonators and is realized on an ultrathin (0.05λ) zeonor substrate. The fabricated quarter waveplate realizes linear to circular polarization conversion in two broad frequency bands comprising 0.64-0.82 THz and 0.96-1.3 THz with an insertion loss ranging from -3.9 to -10 dB. By virtue of ultrathin sub wavelength thickness, the proposed waveplate design is well suited for application in near field THz optical systems. Additionally, the proposed metasurface design offers novel transmission phase characteristics that present further opportunities to realize dynamic polarization control of incident waves.
Phishing URL Detection Via Capsule-Based Neural Network (2019)

As a cyber attack which leverages social engineering and other sophisticated techniques to steal sensitive information from users, phishing attack has been a critical threat to cyber security for a long time. Although researchers have proposed lots of countermeasures, phishing criminals figure out circumventions eventually since such countermeasures require substantial manual feature engineering and can not detect newly emerging phishing attacks well enough, which makes developing an efficient and effective phishing detection method an urgent need. In this work, we propose a novel phishing website detection approach by detecting the Uniform Resource Locator (URL) of a website, which is proved to be an effective and efficient detection approach. To be specific, our novel capsule-based neural network mainly includes several parallel branches wherein one convolutional layer extracts shallow features from URLs and the subsequent two capsule layers generate accurate feature representations of URLs from the shallow features and discriminate the legitimacy of URLs. The final output of our approach is obtained by averaging the outputs of all branches. Extensive experiments on a validated dataset collected from the Internet demonstrate that our approach can achieve competitive performance against other state-of-the-art detection methods while maintaining a tolerable time overhead.
Embryonic stem cell factors and pancreatic cancer (2014)

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic tumor, is a highly aggressive human cancer with the lowest five-year survival rate of any human maligancy primarily due to its early- metastasis and lack of response to chemotherapy and radiation. Recent research suggests that PDAC cells comprise a hierarchy of tumor cells that develop around a population of cancer stem cells (CSCs), a small and distinct population of cancer cells that mediates tumoregenesis, metastasis and resistance to standard treatments. Thus, CSCs could be a target for more effective treatment options. Interestingly, pancreatic CSCs are subject to regulation by some of key embryonic stem cell (ESC) transctiption factors abberently expressed in PDAC, such as SOX2, OCT4 and NANOG. ESC transcription factors are important DNA-binding proteins present in both embryonic and adult somatic cells. The critical role of these factors in reprogramming processes makes them essential not only for embryonic development but also tumorigenesis. Here we provide an overview of stem cell transcription factors, particularly SOX2, OCT4, and NANOG, on their expression and function in pancreatic cancer. In contrast to embryonic stem cells, in which OCT4 and SOX2 are tightly regulated and physically interact to regulate a wide spectrum of target genes, de novo SOX2 expression alone in pancreatic cancer cells is sufficient to promote self-renewal, de-differentiation and imparting stemness characteristics via impacting specific cell cycle regulatory genes and epithelial-mesnechymal transtion driver genes. Thus, targeting ESC factors, particularly SOX2, could be a worthy strategy for pancreatic cancer therapy.
All‐Solid‐State Flexible Ultrathin Micro‐Supercapacitors Based on Graphene (2013)

Flexible, compact, ultrathin and all-solid-state micro-supercapacitors are prepared by coating H₃PO₄/PVA gel electrolyte onto micro-patterned rGO interdigitated electrodes prepared by combining photolithography with selective electrophoretic deposition.
Hierarchical Pd-Sn Alloy Nanosheet Dendrites: An Economical and Highly Active Catalyst for Ethanol Electrooxidation (2013)

Hierarchical alloy nanosheet dendrites (ANSDs) are highly favorable for superior catalytic performance and efficient utilization of catalyst because of the special characteristics of alloys, nanosheets and dendritic nanostructures. In this paper, we demonstrate for the first time a facile and efficient electrodeposition approach for the controllable synthesis of Pd-Sn ANSDs with high surface area. These synthesized Pd-Sn ANSDs exhibit high electrocatalytic activity and superior long-term cycle stability toward ethanol oxidation in alkaline media. The enhanced electrocataytic activity of Pd-Sn ANSDs may be attributed to Pd-Sn alloys, nanosheet dendrite induced promotional effect, large number of active sites on dendrite surface, large surface area and good electrical contact with the base electrode. Because of the simple implement and high flexibility, the proposed approach can be considered as a general and powerful strategy to synthesize the alloy electrocatalysts with high surface areas and open dendritic nanostructures.
Speech intelligibility as a function of the number of channels of stimulation for signal processors using sine-wave and noise-band outputs (1997)

Vowels, consonants, and sentences were processed through software emulations of cochlear-implant signal processors with 2-9 output channels. The signals were then presented, as either the sum of sine waves at the center of the channels or as the sum of noise bands the width of the channels, to normal-hearing listeners for identification. The results indicate, as previous investigations have suggested, that high levels of speech understanding can be obtained using signal processors with a small number of channels. The number of channels needed for high levels of performance varied with the nature of the test material. For the most difficult material--vowels produced by men, women, and girls--no statistically significant differences in performance were observed when the number of channels was increased beyond 8. For the least difficult material--sentences--no statistically significant differences in performance were observed when the number of channels was increased beyond 5. The nature of the output signal, noise bands or sine waves, made only a small difference in performance. The mechanism mediating the high levels of speech recognition achieved with only few channels of stimulation may be the same one that mediates the recognition of signals produced by speakers with a high fundamental frequency, i.e., the levels of adjacent channels are used to determine the frequency of the input signal. The results of an experiment in which frequency information was altered but temporal information was not altered indicates that vowel recognition is based on information in the frequency domain even when the number of channels of stimulation is small.
Acyclovir-Resistant Varicella Zoster Virus Infection after Chronic Oral Acyclovir Therapy in Patients with the Acquired Immunodeficiency Syndrome (AIDS) (1990)

Four patients with human immunodeficiency virus (HIV) infection who received chronic oral acyclovir therapy for suppression of recurrent varicella zoster or herpes simplex virus infection developed persistent disseminated hyperkeratotic papules that failed to heal with intravenous or high-dose oral acyclovir therapy. Varicella zoster virus, resistant to acyclovir in vitro, was isolated from skin lesions of all four patients. Three patients were adults in whom the acquired immunodeficiency syndrome (AIDS) had been diagnosed 12 to 20 months before isolation of acyclovir-resistant varicella zoster virus. The fourth patient was a perinatally HIV-infected child who developed primary varicella infection at age 7 years when profoundly immunosuppressed (absolute CD4+ lymphocyte count less than 50 cells/microL). Mean antiviral susceptibilities (ED50 values) of the four clinical isolates compared with the ED50 values of the reference strain Oka were 85 compared with 3.3 mumol/L for acyclovir, 1.4 compared with 0.8 mumol/L for vidarabine, and 123 compared with 117 mumol/L for foscarnet. When assayed by [125I]-dC plaque autoradiography, 90% to 100% of the viral isolate populations had altered or no measurable thymidine kinase function. Acyclovir-resistant varicella zoster virus infection may complicate long-term oral acyclovir administration in patients with AIDS and may be associated with the appearance of atypical hyperkeratotic papules.
The Managements of Diabetes Mellitus Medical Aid Patients and Their Comorbidities and Complications (2015)

Ba ckground: Because Medicaid beneficiaries (MB) have lower economical status than the National Health Insurance (NHI), MB do not receive adequate medical treatment for the type 2 diabetes mellitus (DM). The objective of this study was to investigate the quality of medical care for type 2 DM inpatients. Me thods: Between March 1, 2013 and December 31, 2014, we retrospectively analyzed the diabetic inpatients’ medical records at a local general hospital. The patients were classified into two groups: MB (n = 42) and NHI (n = 132). The clinical findings; laboratory data; comorbidities such as dyslipidemia, hypertension, smoking rate and drinking rate; and complications were compared between the two groups. Re sults: The MB group had significantly higher hemoglobin A1c levels and dyslipidemia ratio than the NHI group. In addition, the rates of smoking and alcohol consumption in the MB group were markedly higher than those in the NHI group. Conclusion: Because the DM management was insufficient in the MB group, we should provide intensive health care for the MB patients.
Surface Chemistry of Polymers (1968)

ポリエチレンやポリプロピレン,一般にプラスチックが広大な需要をもつようになるとともに,染色,印刷,接着などの二次加工における困難や,静電気に基く障害などが工業的に重大な問題になってきた。これらはいずれも主として界面化学的な問題で,基本的には高分子物質の表面自由エネルギー(表面張力)の知識をもとにして解決の道を探し出すことができる。一方表面張力は液体の分子間相互作用を表わす熱力学的な物理量の一つで,凝集エネルギー密度を実測することのできない高分子では特別な重要性をもっている。さらにそのなかで高分子性(分子がつながっているという効果)を調べるなら,これは学問的にも興味がある。幸い多くの鎖状高分子は溶融することができるので,その表面張力の分子量依存性,分子構造との関係,共重合体の組成との関係などを議論することができる。2種の溶融高分子間の界面張力や溶融高分子による接触角を測定すれば,直接に高分子間の相互作用を議論することもできて,これまた科学的にも工学的にもおもしろい問題ではないか。
Large-scale deployment of the Global Trigger Tool across a large hospital system: refinements for the characterisation of adverse events to support patient safety learning opportunities (2011)

To enhance learning opportunities and guide quality improvement, BHCS collected data-such as preventability and AE source-to characterise the nature of AEs. Data are provided regularly to hospital teams to direct quality initiatives, moving from a general focus on reducing AEs to more specific programmes based on patterns of harm and preventability.
A Prior for Global Convexity in Local Shape-from-Shading (2001)

To solve the ill-posed problem of shape-from-shading, the visual system often relies on prior assumptions such as illumination from above or viewpoint from above. Here we demonstrate that a third prior assumption is used--namely that the surface is globally convex. We use complex surface shapes that are realistically rendered with computer graphics, and we find that performance in a local-shape-discrimination task is significantly higher when the shapes are globally convex than when they are globally concave. The results are surprising because the qualitative global shapes of the surfaces are perceptually unambiguous. The results generalise findings such as the hollow-potato illusion (Hill and Bruce 1994 Perception 23 1335-1337) which consider global shape perception only.
An acoustic identification scheme for location systems (2004)

Many pervasive computing applications require location awareness in order to successfully integrate technology into our daily lives. A location system consists of a group of sensors that determine the position of a mobile user and provide the user with useful context-specific information. Locating the user requires signal exchanges between the user's mobile device and the sensors. This paper considers an acoustic-based location system for pervasive computing applications. The system is comprised of a set of microphones connected to a central server. Mobile users produce acoustic signals through standard speakers, which are already available in most mobile devices, to perform location operations through the system. We focus on the design of robust acoustic signals using multi-frequency symbols that serve both in locating and uniquely identifying the user. We conduct experiments at distances between 1 and 17 ft to explore the ability of the server to recognize and decode signals originated by different users in the same general area.