gebhart/patrepeval huggingface dataset:
[The comparison of heparan sulfate and its fragments on the protection against extracellular histones during the pathogenesis of acute respiratory distress syndrome]. (2018)

<b>Objective:</b> In order to explore the role of heparan sulfate (HS) during the pathogenesis of acute respiratory distress syndrome (ARDS) , the protective effect of HS and its fragments against extracellular histones was compared. <b>Methods:</b> Calf thymus histones (CTH) were injected via femoral vein to induce ARDS in rats. HS, HS fragments or saline was intraperitoneally injected (10mg/kg, Q6h, 24h) to test the protective effect against CTH. The ratio of wet/dry lung weight, protein content in bronchoalveolar lavage fluid (BALF) , total leukocyte and neutrophil count in BALF were measured. <b>Results:</b> After CTH injection, the ratio of wet/dry lung weight (5.7±0.95) was much higher than the saline control group (3.1±0.15). The protein content (0.47±0.086mg/ml) , total leukocyte[ (97.4±15.6l) ×10(4)/ml] and neutrophil (18±3.4/LPF) in BALF were obviously increased compared with the saline control group. The intervention of HS evidently decreased ratio of wet/dry lung weight (4.2±0.41) , protein content[ (0.26±0.019) mg/ml], leukocyte[ (61.3±5.74) ×10(4)/ml] and neutrophil (12±1.8/LPF) in BALF. HS fragments also decreased ratio of wet/dry lung weight, protein content, leukocyte and neutrophil count in BALF though the strength was much less than HS. <b>Conclusion:</b> HS and its fragments could provide protection against extracellular histones during the pathogenesis of ARDS. For the protective effect full length HS was much better than HS fragments.
Dendritic BC1 RNA in translational control mechanisms (2005)

Translational control at the synapse is thought to be a key determinant of neuronal plasticity. How is such control implemented? We report that small untranslated BC1 RNA is a specific effector of translational control both in vitro and in vivo. BC1 RNA, expressed in neurons and germ cells, inhibits a rate-limiting step in the assembly of translation initiation complexes. A translational repression element is contained within the unique 3' domain of BC1 RNA. Interactions of this domain with eukaryotic initiation factor 4A and poly(A) binding protein mediate repression, indicating that the 3' BC1 domain targets a functional interaction between these factors. In contrast, interactions of BC1 RNA with the fragile X mental retardation protein could not be documented. Thus, BC1 RNA modulates translation-dependent processes in neurons and germs cells by directly interacting with translation initiation factors.
Design of Inhibitors of Photosystem II using a Model of the D1 Protein (1996)

Several inhibitors belonging to structurally different chemical classes were used to analyze the predictive power of an initial model of the herbicide binding niche of the D1 protein belonging to photosystem II (PS II) from plants. In the case of small PS II inhibitors, the estimation of relative activities was hampered by uncertainty about the binding modes. To overcome this problem, a bulky substituent was introduced into the inhibitors to act as a hook, resulting in an unambiguous orientation in the model. The comparison of the modelling results and the experimentally determined IC50 values of different triazines suggested that the previously assumed volume of the binding niche had to be reduced by 20%. After refinement of the model, it was possible to estimate qualitatively, the relative in-vitro activity for inhibitors belonging to different families, as long as an unambiguous binding mode could be deduced either from steric demands or from IC50 values of mutant D1 proteins. The usefulness of the refined model is demonstrated by the successful de-novo design of a potent class of herbicides, the triazolopyrimidines.
Fast reservation protocol and statistical multiplexing: a comparative study (2002)

An analytical study of Fast Reservation Protocol is presented as a way to compare FRP performance against simple statistical multiplexing. The comparison is done on the basis of the multiplexing capability of each scheme. Queuing models for both schemes are developed and based on these models the maximum numbers of sources that can be multiplexed by each scheme is then computed. The results quantitatively confirm the previously accepted characteristics of FRP, i.e. that it is good for long burst and short round trip delay.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Ultrasonic Measurement of Concentration in Solutions by a Phase-Locked Loop Method (1997)

In this paper we propose a new ultrasonic technique for measuring the concentration of solutions by a phase-locked loop method. This technique has a very simple circuit system which treats only continuous sinusoidal waves. We verify experimentally its validity and usefulness using NaCl solutions as test specimens. The accurate measurement of concentration is limited by slight changes in the temperature because of the strong temperature dependence of ultrasonic velocity in the solutions. A temperature-compensation factor for NaCl solutions is derived from the equation for ultrasonic velocity in sea water. We designed a circuit compensating for this effect and added it to the measuring system. This measuring system with the compensation circuit was shown to yield accurate values independent of a temperature variation of ±1.3°C around 25° C.
A comparative view on exemplar &#x2018;tracking-by-detection&#x2019; approaches (2015)

In this work, we present a comparative evaluation of various `tracking-by-detection' approaches on public datasets. The work investigates popular sequential Monte Carlo and template ensemble based trackers coupled with relevant visual people detectors with emphasis on exhibited performance variation depending on tracker-detector choice. Extensive experimental results are provided on public dataset and results indicate the choice of a detector can significantly vary the performance of a tracker. Our experimental results show, depending on the choice of the detector, average tracking accuracy across three public datasets could exhibit a 45% standard deviation with only, on average, a 6.8% and 11.1% standard deviation in detector recall and precision respectively.
Einführung (2002)

Die ständig zunehmende Komplexität des Umfeldes unternehmerischen Handelns ist zum geflügelten Wort vieler Einleitungen zu wissenschaftlichen Arbeiten geworden. Jedoch beschäftigt sich die ökonomische Forschung traditionell mit einer objektiv faßbaren Welt, deren Zusammenhänge durch lineare Terme beschrieben werden können und stets dem Gleichgewichtszustand zustreben.1
Ammonia- and Light-Induced Degradation of Paramylum in <italic>Euglena gracilis</italic> (1987)

Ammonium ions (ammonia) induced, independent of light, the degradation of paramylum (beta-l,3-glucan) accumulated in Euglena gracilis var. bacillaris under photoautotrophic and dark-organotrophic conditions. Part of the paramylum in darkorganotrophically grown cells, however, was preserved without breakdown in the dark in the presence of ammonium ions and under carbon-starvation, being degraded on exposure to light.
A <i>Chlamydia</i>   <i>pneumoniae</i> -Specific Peptide Induces Experimental Autoimmune Encephalomyelitis in Rats (2001)

It has been reported recently that the bacterial respiratory pathogen Chlamydia pneumoniae is present in the cerebrospinal fluid of a subset of multiple sclerosis (MS) patients. However, it is not known whether this organism is a causative agent of MS, or merely an opportunistic pathogen that takes advantage of a disease process initiated by some other means. We report identification of a 20-mer peptide from a protein specific to C. pneumoniae which shares a 7-aa motif with a critical epitope of myelin basic protein, a major CNS Ag targeted by the autoimmune response in MS. This bacterial peptide induces a Th1 response accompanied by severe clinical and histological experimental autoimmune encephalomyelitis in Lewis rats, a condition closely reflective of many aspects of MS. Studies with peptide analogues suggest that different populations of encephalitogenic T cells are activated by the C. pneumoniae and myelin basic protein Ags. Mild experimental autoimmune encephalomyelitis was also observed when rats were immunized with sonicated C. pneumoniae in CFA.
Regulation of the oxidative phosphorylation rate in the intact cell (1990)

The mechanisms that underlie the balance between the consumption and oxidative generation of ATP in the intact cell are not well-defined. Cytosolic inorganic phosphate (Pi) and ADP levels, the cytosolic ATP/ADP ratio, and the cytosolic phosphorylation potential (PP) have all been proposed as major regulatory variables, the latter as a component of a "near-equilibrium" thermodynamic regulatory scheme. Therefore, the potential regulatory roles of these variables in the intact cell were evaluated with 31P NMR and Langendorff perfused rat hearts; in this preparation, the tissue oxygen consumption rate (MVO2) can be varied over a wide range. When the exogenous carbon source was varied, none of the proposed regulatory parameters, i.e., the ATP/ADP ratio, PP, or cytosolic ADP level, were found to be uniquely related to MVO2. Rather, ADP levels at a given MVO2 decreased progressively for the exogenous carbon sources in the following order: glucose, glucose + insulin, palmitate + glucose, lactate, pyruvate + glucose, and octanoate + glucose. In the octanoate and pyruvate groups, MVO2(-1) was linearly dependent upon [ADP]-1 with apparent Km values being in the range previously observed in isolated mitochondria. A similar trend was observed in the MVO2-[Pi] relationship. The present findings suggest that exogenous carbon sources which effectuate deregulation of intramitochondrial NADH generation lower cytosolic ADP and Pi to levels which are limiting to the rate of oxidative phosphorylation. For other carbon sources, the processes controlling the rate of NADH generation also participate in determining the rate of oxidative ATP synthesis. However, this control must be exerted kinetically rather than through a near-equilibrium thermodynamic mechanism as indicated by the present data and prior kinetic studies of the ATP synthetic process in both isolated mitochondria and intact myocardium [La Noue, K. F., et al. (1986) Biochemistry 25, 7667-7675; Kingsley-Hickman, P., et al. (1987) Biochemistry 26, 7501-7510].
Subadditivity, Generalized Products of Random Matrices and Operations Research (1988)

An elementary theorem on subadditive sequences provides the key to a far-reaching theory of subadditive processes. One important instance of this theory is the limit theory for products of stationary random matrices. This paper shows that the subadditive inequality that governs the log of the norm of ordinary matrix products also governs other functions of several generalized matrix products. These generalized matrix products are used to calculate minimal cost transportation routes, schedules in manufacturing and minimal and maximal probabilities of multistage processes. The application of subadditive ergodic theory to generalized products of stationary random matrices yields new information about the limiting behavior of generalized products. Exact calculations of the asymptotic behavior are possible in some examples.
Efficacy of avermectin B1a against microfilariae of Dirofilaria immitis. (1979)

Avermectin B1a given at a dose level of 0.05 or 0.1 mg/kg of body weight caused rapid removal of Dirofilaria immitis microfilariae from the blood of dogs with heartworm infections. If the adult worms were also killed with an arsenical (melarsoprol), the removal of microfilariae was permanent.
The Degree of Helicobacter pylori-Triggered Inflammation Is Manipulated by Preinfection Host Microbiota (2013)

Helicobacter pylori infects over 3 billion people worldwide and is the primary risk factor for gastric cancer. Most individuals infected with H. pylori develop only asymptomatic gastritis; however, some develop ulcers or gastric adenocarcinoma. We demonstrate that one previously unappreciated parameter influencing H. pylori disease outcome is variation in the preinfection host microbiota. Utilizing a mouse model, we altered the microbiota by antibiotic treatment and found that these alterations resulted in significantly lowered H. pylori-triggered inflammation. Specifically, antibiotic pretreatment reduced CD4(+) T-helper cells and Ifnγ transcript levels in gastric tissue after H. pylori infection. The bacterial communities in mice with a reduced response to H. pylori displayed many differences from those in untreated mice, including significantly more cluster IV and XIVa Clostridium spp., bacteria known to influence inflammation via regulatory T cell populations. Our findings suggest that microbiota composition, perhaps Clostridium spp., contributes to the variable disease outcome of H. pylori infection by altering the recruitment of CD4(+) T cells to the gastric compartment. Our results suggest that gastric microbiota could be used as a diagnostic tool to determine which patients are at risk for developing severe disease.
Increased Toll-Like Receptors Activity and TLR Ligands in Patients with Autoimmune Thyroid Diseases (2016)

This work is the first to show that TLR2, TLR3, and TLR9 expression and activation are elevated in the PBMCs of patients with AITD and TLRs may participate in the pathogenesis of AITD.
An illustrated guide to common tongue disorders (1986)

Examining the tongue can become a meaningless ritual unless the examiner knows the significance of what he sees.
Pharmacokinetics of 3,5,3'-triiodothyroacetic acid and its effects on serum TSH levels (1989)

3,5,3'-triiodothyroacetic acid is an effective inhibitor of TSH secretion in central hyperthyroidism. Serum, 3,5,3'-triiodothyroacetic acid was measured with an RIA preceded by immunoprecipitation. An anti-3,5,3'-triiodothyroacetic acid antibody was obtained in rabbits, using 3,5,3'-triiodothyroacetic acid coupled to hemocyanin and diazotized benzidine as antigen (cross-reactivity with T4, T3, tetraiodothyroacetic acid was 0.2, 1.1, and 5%, respectively). Endogenous 3,5,3'-triiodothyroacetic acid levels could not be detected in 14 euthyroid, 10 hypothyroid and 10 hyperthyroid sera (detection limit 0.055 nmol/l). Kinetic studies were performed in 6 healthy male subjects who received an oral and an iv dose of 1050 micrograms of 3,5,3'-triiodothyroacetic acid. The serum measurements were analysed according to a non-compartmental method. The half-life of 3,5,3'-triiodothyroacetic acid was 6 h 22 min +/- 29 min, the volume of distribution was 114 +/- 9 1/70 kg, and the plasma clearance rate was 298 +/- 141.(70 kg)-1.day-1. Highest 3,5,3'-triiodothyroacetic acid levels were measured after 40 min (for T3 2-3 h) and its absorption was 67 +/- 6%. The nadir of the mean TSH levels was 0.72 +/- 0.09 mU/l 6 h after 3,5,3'-triiodothyroacetic acid administration. However, the time course of serum TSH response did not differ from that obtained after administration of 37.5 micrograms T3. The dose-response effect for TSH was studied using oral doses of 350, 700, 1400 and 2800 micrograms 3,5,3'-triiodothyroacetic acid. TSH was measured 9 h after 3,5,3'-triiodothyroacetic acid administration at 17.00 h, and compared with control serum TSH levels obtained at 08.00 h (1.53 +/- 0.11) and at 17.00 h the day before the test (1.87 +/- 0.11). They were 1.05 +/- 0.15 (N = 9, mean +/- SEM), 0.83 +/- 0.08 (N = 24), 0.66 +/- 0.06 (N = 24), and 0.43 +/- 0.02 mU/l (N = 6), respectively. In conclusion, TSH inhibition by 3,5,3'-triiodothyroacetic acid is similar to T3, with a potency ratio of 1 to 18.
Controlled reproducible alignment of cone targets and mitigation of preplasma in high intensity laser interactions (2008)

The use of cone targets in high intensity laser-plasma experiments has been of recent interest because of their potential use in integrated fast ignition experiments. Simpler experiments provide a good avenue for understanding the underlying physics, however precise control of the alignment along with good pointing accuracy is of crucial importance. While on big laser facilities target alignment is done precisely with several microscopes, it is not always the case on smaller facilities. This can have a detrimental effect on the quality of the results. We have developed and characterized a method for accurate alignment of intense laser pulses into a cone target. This, along with optimal positioning of the focus compared to the tip, efficiently uses the shape of the target to microfocus the laser light and concentrates the hot electrons in the tip, and can mitigate preplasma issues.
Flexible and adaptable buffer management techniques for database management systems (1995)

The problem of buffer management in database management systems is concerned with the efficient main memory allocation and management for answering database queries. Previous works on buffer allocation are based either exclusively on the availability of buffers at runtime or on the access patterns of queries. In this paper, we first propose a unified approach for buffer allocation in which both of these considerations are taken into account. Our approach is based on the notion of marginal gains which specify the expected reduction in page faults by allocating extra buffers to a query. Then, we extend this approach to support adaptable buffer allocation. An adaptable buffer allocation algorithm automatically optimizes itself for the specific query workload. To achieve this adaptability, we propose using runtime information, such as the load of the system, in buffer allocation decisions. Our approach is to use a simple queuing model to predict whether a buffer allocation will improve the performance of the system. Thus, this paper provides a more theoretical basis for buffer allocation. Simulation results show that our methods based on marginal gains and our predictive methods consistently outperform existing allocation strategies. In addition, the predictive methods have the added advantage of adjusting their allocation to changing workloads.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Immunological behavior (IgG, IgM, IgA) and total complement (CH50) of newborns infants with risk factors for early onset sepsis. Comparative analysis of newborns with and without infection]. (1999)

Immunological behavior (IgG, IgM, IgA) and total Complement (CH50) of newborns infants with risk factors for early onset sepsis. Comparative analysis between newborns with and without infection. Rev. Hosp. Clín. Fac. Med. S. Paulo, 53(6): 303-310, 1998. The objective of this study was to verify the immunological behavior of the newborn infant in front of an infection. We studied 60 newborn infants that had risk factors for early onset sepsis (premature rupture membranes, clinic amnionitis or tract urinary infection) from de immunological and infection point of view. They were classified into three gestational age groups: < 34 weeks, between 34 and 36 6/7 weeks and > or = 37 weeks. Sepsis diagnosis was done through clinical and laboratorial data and we also included the followings exams: Immunological types (IgG, IgM, IgA) and total complement (CH50) obtained from the newborn at birth and on the fifth day of life. We could verify that 15 newborns (25%) presented early sepsis. There was a statistical association between perinatal asfixia and infection in the group with gestational age < 34 weeks and this same group presented statistical association between infection and death. The serical levels of IgG and CH50 were directly related to the gestational age and there were significant statistical differences between levels of IgG, IgM and total Complement between infected and not infected newborns within the same group os gestional age. We observed that the infection was associated to low levels of IgG and CH50, at birth and on the fifth day, mainly in the group of infected newborns with gestional age < 34 weeks, being this group, therefore, the one that would mostly benefit from an immunological support in front of and infection.
Design Technologies for Low Power VLSI (1995)

Breast cancer (BC) is one of the most common cancers in women. Evidence suggests that genetic variation in antioxidant enzymes could influence BC risk, but to date the relationship between selenoproteins and BC risk remains unclear. In this report, a study population including 975 Danish cases and 975 controls matched for age and hormone replacement therapy (HRT) use was genotyped for five functional single nucleotide polymorphisms (SNPs) in SEPP1, GPX1, GPX4 and the antioxidant enzyme SOD2 genes. The influence of genetic polymorphisms on breast cancer risk was assessed using conditional logistic regression. Additionally pre-diagnosis erythrocyte GPx (eGPx) activity was measured in a sub-group of the population. A 60% reduction in risk of developing overall BC and ductal BC was observed in women who were homozygous Thr carriers for SEPP1 rs3877899. Additionally, Leu carriers for GPX1 Pro198Leu polymorphism (rs1050450) were at ∼2 fold increased risk of developing a non-ductal BC. Pre-diagnosis eGPx activity was found to depend on genotype for rs713041 (GPX4), rs3877899 (SEPP1), and rs1050450 (GPX1) and on HRT use. Moreover, depending on genotype and HRT use, eGPx activity was significantly lower in women who developed BC later in life compared with controls. Furthermore, GPx1 protein levels increased in human breast adenocarcinoma MCF7 cells exposed to β-estradiol and sodium selenite.In conclusion, our data provide evidence that SNPs in SEPP1 and GPX1 modulate risk of BC and that eGPx activity is modified by SNPs in SEPP1, GPX4 and GPX1 and by estrogens. Our data thus suggest a role of selenoproteins in BC development.
An Extended Shared Logarithmic Unit for Nonlinear Function Kernel Acceleration in a 65-nm CMOS Multicore Cluster (2016)

Energy-efficient computing and ultralow-power computing are strong requirements for various application areas, such as internet of things and wearables. While for some applications integer and fixed-point arithmetic suffice, others require a larger dynamic range, typically obtained using floating-point (FP) numbers. Logarithmic number systems (LNSs) have been proposed as energy-efficient alternative, since several complex FP operations translate into simple integer operations. However, additions and subtractions become nonlinear operations, which have to be approximated via interpolation. Even efficient LNS units (LNUs) are still larger than standard FP units (FPUs), rendering them impractical for most general-purpose processors. We show that, when shared among several cores, LNUs become a very attractive solution. A series of compact LNUs is developed, which provide significantly more functionality (such as transcendental functions) than other state-of-the-art designs. This allows, for example, to evaluate the atan2 function with three instructions for only 183.2 pJ/op at 0.8 V. We present the first shared-LNU architecture where these LNUs have been integrated into a multicore system with four 32-b-OpenRISC cores and show measurement results demonstrating that the shared-LNU design can be up to 4.1× more energy-efficient in common nonlinear processing kernels, compared with a similar area design with four private FPUs.