gebhart/patrepeval huggingface dataset:
Theory and Flight-Test Validation of a Concurrent-Learning Adaptive Controller (2011)

Theory and results of flight-test validation are presented for a novel adaptive law that concurrently uses current as well as recorded data for improving the performance of model reference adaptive control architectures. This novel adaptive law is termed concurrent learuing. This adaptive law restricts the weight updates based on stored data to the null-space of the weight updates based on current data for ensuring that learning on stored data does not affect responsiveness to current data. This adaptive law alleviates the rank-1 condition on weight updates in adaptive control, thereby improving weight convergence properties and improving tracking performance. Lyapunov-like analysis is used to show that the new adaptive law guarantees uniform ultimate boundedness of all system signals in the framework of model reference adaptive control. Flight-test results confirm expected improvements in performance.
Analysis of wines for resveratrol using direct injection high-pressure liquid chromatography with electrochemical detection (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalysis of wines for resveratrol using direct injection high-pressure liquid chromatography with electrochemical detectionKenneth D. McMurtrey, James Minn, Kirk Pobanz, and Tor P. SchultzCite this: J. Agric. Food Chem. 1994, 42, 10, 2077–2080Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/jf00046a001https://doi.org/10.1021/jf00046a001research-articleACS PublicationsRequest reuse permissionsArticle Views480Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Toll-like receptor 2 activation and serum amyloid A regulate smooth muscle cell extracellular matrix (2017)

Smooth muscle cells contribute to extracellular matrix remodeling during atherogenesis. De-differentiated, synthetic smooth muscle cells are involved in processes of migration, proliferation and changes in expression of extracellular matrix components, all of which contribute to loss of homeostasis accompanying atherogenesis. Elevated levels of acute phase proteins, including serum amyloid A (SAA), are associated with an increased risk for atherosclerosis. Although infection with periodontal and respiratory pathogens via activation of inflammatory cell Toll-like receptor (TLR)2 has been linked to vascular disease, little is known about smooth muscle cell TLR2 in atherosclerosis. This study addresses the role of SAA and TLR2 activation on smooth muscle cell matrix gene expression and insoluble elastin accumulation. Cultured rat aortic smooth muscle cells were treated with SAA or TLR2 agonists and the effect on expression of matrix metallopeptidase 9 (MMP9) and tropoelastin studied. SAA up-regulated MMP9 expression. Tropoelastin is an MMP9 substrate and decreased tropoelastin levels in SAA-treated cells supported the concept of extracellular matrix remodeling. Interestingly, SAA-induced down-regulation of tropoelastin was not only evident at the protein level but at the level of gene transcription as well. Contributions of proteasomes, nuclear factor κ B and CCAAT/enhancer binding protein β on regulation of MMP9 vs. tropoleastin expression were revealed. Effects on Mmp9 and Eln mRNA expression persisted with long-term SAA treatment, resulting in decreased insoluble elastin accumulation. Interestingly, the SAA effects were TLR2-dependent and TLR2 activation by bacterial ligands also induced MMP9 expression and decreased tropoelastin expression. These data reveal a novel mechanism whereby SAA and/or infection induce changes in vascular elastin consistent with atherosclerosis.
General Model of Fluid Flow (Leakoff) From Fractures Induced in Injection Operations (1988)

Abstract The paper describes a new general model of leak-off from fractures. The model is an extension of earlier work, generalized to handle multi-phase flow conditions, influence of reservoir boundaries and faults, well interference and voidage replacement in a pattern, and the compressibility of the injected fluid. The model was successfully incorporated in a 3-D fracture simulator. The capabilities of the method are demonstrated on examples of fractures in waterflood injector, in tar sands and in a WAG injection scheme.
A Retinal Neuronal Developmental Wave of Retinoschisin Expression Begins in Ganglion Cells during Layer Formation (2004)

All major classes of adult retinal neurons, with the possible exception of horizontal cells, express RS protein and mRNA, strongly suggesting that retinoschisin in the inner retina is synthesized locally rather than being transported, as earlier proposed, from distal retinal photoreceptors. Continued expression of RS by mature inner-retinal neurons supports the possibility of a therapeutic strategy of protein replacement to treat both infants and adults with XLRS.
Privatization: Reforming the Welfare State (1987)

The American social welfare institution is in transition. Constituencies of the welfare state-the public, clients, and professionals-have registered dissatisfaction with traditional methods of providing services. Analysts from liberal and conservative think tanks have proposed relying less on government and more on the private sector to provide for welfare. To a substantial degree privatization is already evident in several areas: the expansion of for-profit health and welfare corporations, the application of entrepreneurial methods in community development, and the encouragement of private retirement plans. The liberal response to privatization is poorly developed, and could benefit from insights by welfare professionals who seek to make privatization consistent with a progressive welfare agenda.
Vocational outcome of aphasic patients following severe traumatic brain injury (1996)

The incidence and course of aphasia, and its impact on vocational outcome, were determined in a group of 351 patients with severe traumatic brain injury (TBI). Aphasia was found in 11.1%, the common forms being amnestic (56%, 22/39), expressive (10.3%, 4/39) and receptive (10.5%, 8/39), as found on the first language assessment. No age difference was found between the aphasic and non-aphasic patients. Coma was more common in the aphasics than the non-aphasics (95% and 82%, respectively), although its mean duration was shorter. Aphasics had more severe locomotor deficits (p < 0.01, Fisher test) and tended towards more severe cognitive disorders (p = 0.07, Fisher test). There was no difference between the groups in incidence of behavioural disturbances or occupational outcome. Most of the aphasic patients improved after therapy, and two recovered completely. The presence of aphasia did not have negative prognostic implications for occupational outcome.
Exposure of normal human melanocytes to a tumor promoting phorbol ester reverses growth suppression by transforming growth factor beta (2007)

Transforming growth factor-beta (TGF-beta), a potent inhibitor of normal melanocyte growth, does not significantly suppress growth of melanoma cells. The mechanism of melanocyte desensitization to TGF-beta in the transformation process remains largerly unknown. We investigated whether the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) may induce melanocyte resistance to TGF-beta. Cell proliferation and DNA synthesis of normal human melanocytes were strongly inhibited by TGF-beta, whereas in the presence of TPA remained largerly unaffected. The inactive phorbol ester 4alpha-phorbol 12,13 didecanoate did not modify the TGF-beta antiproliferative effect, whereas the diacylglycerol analog 1-oleoyl-2-acetyl-sn-glycerol counteracted TGF-beta effects. Protein kinase C (PKC) is the major cellular receptor of tumor promoting phorbol esters. PKC-alpha expression and phosphorylation were almost completely downregulated under combined treatment with TGF-beta + TPA at 24 and 72 h, as shown by immunoblots. Confocal microscopy demonstrated that TGF-beta-induced nuclear accumulation of PKC-alpha was abolished in the presence of TPA at the same time points. The selective PKC inhibitor Ro-31-8220 weakened the TGF-beta antiproliferative effect. Smads are central mediators for TGF-beta signal transduction. Smad-dependent transcriptional activity was suppressed in TGF-beta-treated melanocytes in the presence of TPA, as well as in ALK5 (constitutively active type I TGF-beta receptor)- or Smad3 + Smad4-transfected melanocytes in the presence of Ro-31-8220. In addition, an antisense oligodeoxynucleotide against PKC-alpha abolished TGF-beta-driven Smad-mediated transcription. These findings show that tumor promoting phorbol esters induce melanocyte resistance to TGF-beta, associated with downregulation of PKC-alpha and suppression of Smad-dependent transcription. This may represent an important mechanism for expansion of melanocytes exposed to PKC-targeting tumor promoters.
Solid and liquid crystalline phases in the sodium dodecyl sulphate + hexadecanoic acid + water system (1976)

In this work an outline has been obtained of the ternary diagram for the sodium dodecyl sulphate + hexadecanoic acid + water system at 50°C using optical, n.m.r. and differential thermal methods.Areas of lamellar and hexagonal mesophases have been defined and the minimum temperatures for the existence of these mesophases in the ternary system and also in the binary sodium dodecyl sulphate + water system have been determined.These temperatures have been correlated with the minimum temperatures at which sodium dodecyl sulphate solution will interact with hexadecanoic acid crystals to form lamellar and hexagonal liquid crystalline phases.The constant temperature of formation of the lamellar mesophase in ternary mixtures has been correlated with the existence of a solid compound of composition, 2SDS : C16A : xH2O, where x∼ 8. This has been confirmed by examining in detail specific areas of the phase diagram at lower temperatures, and by the use of broad line nuclear magnetic resonance spectroscopy.
Wrapper induction: Efficiency and expressiveness (Extended abstract) (1998)

) Nicholas Kushmerick School of Computer Applications, Dublin City University, Ireland nick@compapp.dcu.ie ABSTRACT Recently, many systems have been built that automatically interact with Internet information resources. However, these resources are usually formatted for use by people; e.g., the relevant content is embedded in HTML pages. Wrappers are often used to extract a resource&apos;s content, but hand-coding wrappers is tedious and error-prone. We advocate wrapper induction, a technique for automatically constructing wrappers. We have identified several wrapper classes that can be learned quickly (most sites require only a handful of examples, consuming a few CPU seconds of processing), yet which are useful for handling numerous Internet resources (70% of surveyed sites can be handled by our techniques). 4.1 Introduction The Internet presents a stunning variety of on-line information resources: telephone directories, retail product catalogs, weather forecasts, and many more. Recen...
Improvement of lipase stability in the presence of commercial triglycerides (2003)

Abstract Several compounds generated by atmospheric oxidation of triglycerides, such as hydroperoxides and secondary products, may cause significant lipase inactivation in low‐water medium. Activity decay is usually time‐dependent and shows a non‐linear dependence on inactivating compound concentration. As the effect of very dilute poisons becomes much more significant in continuous operations, stability tests were performed in the presence of oxidized oils in batch and continuous reactors. Experimental results show that the stability of Novozyme 435 is affected by secondary products of oxidation more than by hydroperoxides. Involvement of sulphydryl groups in the mechanism of lipase interaction with two aldehydes, 4‐hydroxynonenal (4‐HNE) and malondialdehyde (MDA), has been demonstrated by blocking the lipase sulphydryl groups with pHMB pre‐treatment. The preliminary neutralization 4‐HNE and MDA with albumin also increased enzyme stability.
Preparation of Hydroxyapatite/Poly(ε-caprolactone) Hybrid Microspheres for Drug Release System (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Ultraviolet Light May Contribute to Geographic and Racial Blood Pressure Differences (1997)

Mean systolic and diastolic pressures and the prevalence of hypertension vary throughout the world. Published data suggest a linear rise in blood pressure at increasing distances from the equator. Similarly, blood pressure is higher in winter than summer. Blood pressure also is affected by variations in skin pigmentation. Altered calcium, vitamin D, and parathyroid hormone status is associated with hypertension and may vary with latitude and season. Since changes in UV light affect vitamin D and parathyroid hormone status and UV light intensity are influenced by seasonal change and latitude, these disparate observations suggest an association between blood pressure and ultraviolet light. This discussion presents the hypothesis that reduced epidermal vitamin D3 photosynthesis associated with high skin melanin content and/or decreased UV light intensity at distances from the equator, alone or when coupled with decreased dietary calcium and vitamin D, may be associated with reduced vitamin D stores and increased parathyroid hormone secretion. These changes may stimulate growth of vascular smooth muscle and enhance its contractility by affecting intracellular calcium, adrenergic responsiveness, and/or endothelial function. Thus, UV light intensity and efficiency of epidermal vitamin D3 photosynthesis may contribute to geographic and racial variability in blood pressure and the prevalence of hypertension.
Human &#946;-secretase (BACE) and BACE Inhibitors: Progress Report (2006)

A key step in the processing of the integral membrane protein APP, or Amyloid Precursor Protein is through the proteolytic cleavage by the enzyme beta-Secretase (BACE). The proteolysis of APP by BACE, followed by subsequent C-terminal cleavage(s) by gamma-secretase, results in the formation of the amyloid beta (Abeta) peptide. The principal component of the neuritic plaque found in the brains of Alzheimer's Disease (AD) patients is Abeta which is a neurotoxic and highly aggregatory peptide segment of APP. The amyloid hypothesis holds that the neuronal dysfunction and clinical manifestation of AD is a consequence of the long term deposition and accumulation of 40-42 amino-acid long Abeta peptides, and that this process leads to the onset and progression of AD. Due to the apparent causal relationship between Abeta and AD, the so-called "secretases" that produce Abeta have been targeted for development of inhibitors that might serve as therapeutic agents for treatment of this dreaded, and ever more prevalent disease. Herein will be discussed our current understanding of BACE, its role in the formation of neuritic plaques and the known inhibitors of the enzyme.
Macromolecular Design via the Interchange of Xanthates (MADIX): Polymerization of Styrene with <i>O</i>‐Ethyl Xanthates as Controlling Agents (2002)

Abstract Control of the free‐radical polymerization of styrene was achieved using a series of eight xanthates of the general structure RS(CS)OEt as reversible addition fragmentation chain‐transfer agents. The influence of the nature of the R leaving group was explored. It was found that the transfer ability of the xanthate is markedly improved with increasing stability of R and its steric hindrance. Group R strongly influences the M n evolution profile during polymerization, but only influences the polydispersities to a small extent. The cyanoisopropyl group was shown to be the best leaving group, leading to an increase in the molecular weight during polymerization that was close to linearity. The living character of the polymerization and the high purity of the chain structures were supported by matrix‐assisted laser desorption ionization time‐of‐flight (MALDI‐TOF) mass spectrometry and 13 C NMR spectroscopy. A zero‐order dependence of the kinetics of polymerization on the xanthate concentration was observed. Conversion versus time plots for thermal bulk polymerizations of styrene at 110 °C in the presence of various xanthates. magnified image Conversion versus time plots for thermal bulk polymerizations of styrene at 110 °C in the presence of various xanthates.
Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. (1977)

A peptide that induces slow-wave (delta) and spindles electroencephalogram enhancement after intraventricular (brain) infusion has been isolated from rabbits and given the name delta-sleep-inducing peptide (DSIP). Amino acid seqeunce: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. This compound, five possible metabolic products (containing residues 1--8, 2--9, 2--8, 1--4, and 5--9), two nonapeptide analogues with two amino acids exchanged, and a related tripeptide (Trp-Ser-Glu) were synthesized. All nine synthetic peptides were infused intraventricularly in rabbits under double-blind conditions. A total of 58 rabbits including controls were evaluated. The electroencephalogram leads from the neocortex and the archicortex were directly fast-Fourier transformed and analyzed by a Univac 1108 computer system. Only the delta-sleep-inducing peptide (snythetic) showed significant and specific enhancement/induction of delta and spindle electroencephalogram patterns.
Code placement and replacement strategies for wideband CDMA OVSF code tree management (2002)

The use of OVSF codes in WCDMA systems has offered opportunities to provide variable data rates to flexibly support applications with different bandwidth requirements. Two important issues in such an environment are the code placement problem and code replacement problem. The former may have significant impact on code utilization and, thus, code blocking probability, while the latter may affect the code reassignment cost if dynamic code assignment is to be conducted. The general objective is to make the OVSF code tree as compact as possible so as to support more new calls by incurring less blocking probability and less reassignment costs. Earlier studies about these two problems either do not consider the structure of the OVSF code tree or cannot utilize the OVSF codes efficiently. To reduce the call blocking probability and the code reassignment cost, we propose two simple yet efficient strategies that can be adopted by both code placement and code replacement: leftmost and crowded-first. Numerical analyses on call blocking probability and bandwidth utilization of OVSF code trees when code reassignment is supported are provided. Our simulation results show that the crowded-first strategy can significantly reduce, for example, the code blocking probability by 77 percent and the number of reassignments by 81 percent, as opposed to the random strategy when the system is 80 percent fully loaded and the max SF = 256.
DACC: Distributed Access Control in Clouds (2011)

We propose a new model for data storage and access in clouds. Our scheme avoids storing multiple encrypted copies of same data. In our framework for secure data storage, cloud stores encrypted data (without being able to decrypt them). The main novelty of our model is addition of key distribution centers (KDCs). We propose DACC (Distributed Access Control in Clouds) algorithm, where one or more KDCs distribute keys to data owners and users. KDC may provide access to particular fields in all records. Thus, a single key replaces separate keys from owners. Owners and users are assigned certain set of attributes. Owner encrypts the data with the attributes it has and stores them in the cloud. The users with matching set of attributes can retrieve the data from the cloud. We apply attribute-based encryption based on bilinear pairings on elliptic curves. The scheme is collusion secure; two users cannot together decode any data that none of them has individual right to access. DACC also supports revocation of users, without redistributing keys to all the users of cloud services. We show that our approach results in lower communication, computation and storage overheads, compared to existing models and schemes.
Tissue distributions of 97Ru and 103Ru in subcutaneous tumor of rodents. (1975)

Mice bearing Ehrlich tumor were administered 97Ru-chloride or 103Ru-chloride intravenously. Examinations of various tissues indicated similar distributions by the two radionuclides. The levels were higher in the lung, liver and kidney than in the tumor tissue. Rats bearing AH-130 tumor were administered 103Ru-chloride intravenously. The 103Ru distribution in rats was highest in the spleen, followed by the liver and kidney; however, the radioactive distribution in the tumor tissue exceeded the muscle level by about 5-fold. Tumors were delineated in rats by scintigraphy. The findings indicate that ruthenium radionuclides may be a useful clinical agent in the delineation of some types of tumors. Ruthenium-97 would be favored in possible clinical usage due to its shorter physical half-life and lower levels of gamma energy.
Pattern formation and chaos in networks (1988)

Chaos theory involves the study of how complicated behavior can arise in systems that are based on simple rules, and how minute changes in the input of a system can lead to great differences in the output. Using computer graphics, the dynamic behavior of chaos-producing networks is explored, and convergence maps reveal a visually striking and intricate class of displayable objects.