gebhart/patrepeval huggingface dataset:
Loss of high affinity cardiac beta adrenergic receptors in dogs with heart failure. (1985)

We studied the alterations in myocardial beta-adrenergic receptor-adenylate cyclase activity and muscarinic receptor density in a canine model of left ventricular (LV) failure. LV failure was characterized by a doubling of LV weight/body weight ratio (3.3 +/- 0.1 to 6.9 +/- 0.4 g/kg) and an elevation of LV end-diastolic pressure, 32 +/- 4.5 mmHg, compared with 7.7 +/- 0.6 mmHg in normal dogs. Despite a 44% increase in receptor density as measured by antagonist binding studies with [3H]dihydroalprenolol, there was a twofold decrease in receptor affinity, i.e., an increase in the dissociation constant (Kd) (5.6 +/- 0.7 to 12 +/- 1.6 nM) in heart failure. Agonist displacement of [3H]dihydroalprenolol binding with isoproterenol in the presence and absence of 5'-guanylylimidodiphosphate [Gpp(NH)p] demonstrated a striking loss of high affinity binding sites in heart failure (51 +/- 16 to 11 +/- 5%). Beta-Adrenergic receptor-mediated stimulation of adenylate cyclase and maximal stimulation with Gpp(NH)p or sodium fluoride was reduced in heart failure. There was a concomitant marked, P less than 0.01, reduction in muscarinic receptor density (242 +/- 19 vs. 111 +/- 20 fmol/mg). Thus, while muscarinic receptor density fell, beta-adrenergic receptor density actually increased in LV failure. However, a larger portion of the beta-adrenergic receptors are not functionally coupled to the GTP-stimulatory protein (Ns), as evidenced by a decrease in the fraction of receptors that bind agonist with high affinity.
p27 as Jekyll and Hyde: Regulation of cell cycle and cell motility (2009)

p27 is a key regulator of cell proliferation. While it opposes cell cycle progression by binding to and inhibiting cyclin E-Cdk2, T157/T198 phosphorylation of p27 promotes its assembly of D-type cyclin-CDKs. In addition to its actions on the cell cycle, p27 regulates CDK-independent cytoplasmic functions. In human cancers, oncogenic activation of the PI3K signaling pathway often results in cytoplasmic mislocalization of p27. Cytoplasmic p27 plays an important role in cell motility and migration; it binds RhoA and modulates activation of the RhoA/ROCK cascade. p27:RhoA binding is facilitated by p27 phosphorylation at threonine 198. Accumulation of cytoplasmic p27 leads to increased cellular motility, a critical event in tumor metastasis. Further characterization of post-translational modifications governing p27 localization and its action on RhoA and the actin cytoskeleton may provide critical insights into human cancer metastasis.
Story retelling and Attention Deficit Hyperactivity Disorder (2001)

ni des extraits substantiels de celle-ci ne doivent tre imprims ou autrement reproduits sans son autorisation.
Evaluation of the Antibacterial Activity and Biocompatibility for Silver Nanoparticles Immobilized on Nano Silicate Platelets (2012)

Silver nanoparticles (AgNPs) are known for their bactericidal abilities. The antibacterial potency is dependent on the particle size and dispersion status. In this study, we synthesized AgNP/NSP nanohybrids in two different weight ratios (1/99 and 8/92) using the fully exfoliated clay, i.e., nanosilicate platelets (NSP), as a dispersing agent and carrier for AgNPs. Due to the size of NSP, the immobilized AgNPs do not enter cells readily, which may lower the risk associated with the cellular uptake of AgNPs. The biocompatibility, immunological response, and antimicrobial activities of AgNP/NSP hybrids were evaluated. The results revealed that AgNP/NSP hybrids elicited merely mild inflammatory response and retained the outstanding antibacterial activity. The hybrids were further embedded in poly(ether)urethane (PEU) to increase the biocompatibility. At the same silver content (20 ppm), the PEU-AgNP/NSP nanocomposites were nontoxic to mouse skin fibroblasts, while simultaneously exhibiting nearly complete bacterial growth reduction (99.9%). PEU containing the same amount of free AgNPs did not display such an effect. Our results verify the better biosafety of the AgNPs/NSP hybrids and their polymer nanocomposites for further clinical use.
Bottom-up induction of oblivious read-once decision graphs: strengths and limitations (1994)

We report improvements to HOODG, a supervised learning algorithm that induces concepts from labelled instances using oblivious, read-once decision graphs as the underlying hypothesis representation structure. While it is shown that the greedy approach to variable ordering is locally optimal, we also show an inherent limitation of all bottom-up induction algorithms, including HOODG, that construct such decision graphs bottom-up by minimizing the width of levels in the resulting graph. We report our empirical experiments that demonstrate the algorithm&apos;s generalization power. Introduction In supervised classification learning, one tries to find a structure, such as a decision-tree, a neural net, or a Boolean formula, that can be used to accurately predict the label of novel instances. A given concept can be represented by different structures that differ in many aspects, including comprehensibility, storage size, and query time. Decision trees provide one structure that is commonly const...
Powering tomorrow's data internetworking systems (2002)

The Telecoms evolution will require a number of new data internetworking equipment including high speed central processing units (CPU), digital signal processors (DSP) and high speed transmission routers and switches at 10 Gbit/s, or more, for LAN and WAN switching, Sonet and SDH systems. A mix of both fixed and mobile access network systems will be connected to this new common connectivity network's access points. These new data internetworking equipment and access network systems will include cost sensitive on-board power solutions and distributed power architectures (DPA), using 48 V DC system voltage, will become the preferred power system solution. The power requirements for on-board DC/DC converters are ranging from 10 W per board, in telecom switching and cellular radio applications, up to more than 200 W per board, in high speed CPUs and high speed 10 Gbit/s routers. To manage and become a successful on-board power solution provider in this telecom evolution it will require close co-operation with the equipment manufacturers, to understand the different applications' requirements, both technical skillness and resources as well as high manufacturing volumes and high automation levels to meet the technical requirements and the demand for improved cost/performance ratio.
Instrument for measuring spacecraft potential (1998)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
BATHYMETRY OF ADAK CANYON, ALEUTIAN ARC, ALASKA (1965)

Research Article| March 01, 1965 BATHYMETRY OF ADAK CANYON, ALEUTIAN ARC, ALASKA RICHARD B PERRY; RICHARD B PERRY OFFICE OF RESEARCH AND DEVELOPMENT, U. S. COAST AND GEODETIC SURVEY, WASHINGTON, D. C. Search for other works by this author on: GSW Google Scholar HAVEN NICHOLS HAVEN NICHOLS OFFICE OF RESEARCH AND DEVELOPMENT, U. S. COAST AND GEODETIC SURVEY, WASHINGTON, D. C. Search for other works by this author on: GSW Google Scholar GSA Bulletin (1965) 76 (3): 365–370. https://doi.org/10.1130/0016-7606(1965)76[365:BOACAA]2.0.CO;2 Article history received: 23 Aug 1964 first online: 02 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share MailTo Twitter LinkedIn Tools Icon Tools Get Permissions Search Site Citation RICHARD B PERRY, HAVEN NICHOLS; BATHYMETRY OF ADAK CANYON, ALEUTIAN ARC, ALASKA. GSA Bulletin 1965;; 76 (3): 365–370. doi: https://doi.org/10.1130/0016-7606(1965)76[365:BOACAA]2.0.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGSA Bulletin Search Advanced Search Abstract Bathymetric analysis of hydrographic data taken in the region of Adak Canyon on the southern slope of the Aleutian Ridge off Alaska indicates that the canyon is a distinct and important boundary between an essentially regular, convex slope to the east and a topographically chaotic slope to the west. The unusually sheer east wall of the canyon appears to be the scarp of a major fault trending normal to the southern slope of the Aleutian Ridge. The canyon also separates an area of relatively high seismic activity to the west from an area of apparent stability to the east. These features suggest that the canyon is a major boundary feature between dissimilar geological units. This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Vers une meilleure utilisabilité des mémoires de traduction, fondée sur un alignement sous-phrastique (2005)

Computer aided translation has known a boost in the years 1990s with the introduction of translation memory-based environments. These systems take advantage of the repetitiveness of technical materials that are produced and translated in the industry, by allowing translators to reuse archive translation thus improving their productivity. Translation memories use text segments (typically whole sentences) delineated and aligned thanks to the translators expertise, and do not perform any advanced analysis. <br /><br />However, these memories contain very rich information at sub-sentential levels but translators cannot benefit from it. The TransTree formalism captures nested correspondences between sub-segments of bilingual or multilingual texts. These complex correspondences, called amphigrams, make up a tree structure that is easily expressed in XML. With a simple shallow transformation, a dynamical visualization can be obtained that demonstrates several levels of correspondences between sub-segments. <br /><br />TransTree comes with a general, statistical method to compute this information, based on binary secability trees. This method analyses any bisegment and programmatically produces a TransTree representation from correspondences between typographical words in bisegments. Moreover, it is possible to abstract translation patterns, called generic amphigrams, by clustering techniques over examples found in the corpus. <br /><br />A few experiments were conducted to validate the expressive power of the formalism, investigate several implementation options and introduce an algorithm to reassemble a target string from a previously unseen source segment with knowledge extracted from translation memories.
Changes in cobalamin metabolism are associated with the altered methionine auxotrophy of highly growth autonomous human melanoma cells (1991)

Our aim was to identify the biochemical defect responsible for the inability of highly growth autonomous human tumor cells to proliferate in culture medium devoid of methionine, but containing homocysteine and 5-methyletrahydrofolic acid. We have adopted the terms "homocysteine-responsive" and "homocysteine-nonresponsive" to describe cells which can or cannot proliferate in methionine-free homocysteine-supplemented medium. Using a panel of genetically related homocysteine-responsive and -nonresponsive human melanoma cell lines, the results from a number of experiments indicate that acquisition of the "homocysteine-nonresponsive phenotype" is associated with the reduced intracellular accumulation of methyl-cobalamin, a critical cofactor of the methionine synthase enzyme. When in vitro methionine synthase assays were performed in the presence of exogenously added methyl-cobalamin, specific methionine synthase activity in extracts obtained from homocysteine-responsive cells was only twofold greater than that observed with extracts prepared from homocysteine-nonresponsive cells. However, when exogenous methyl-cobalamin was omitted from the enzyme assays, methionine synthase activity in extracts derived from homocysteine-nonresponsive cells was dramatically reduced, compared with the small decrease observed with homocysteine-responsive cell extracts. Compared with their homocysteine-responsive counterparts, homocysteine-nonresponsive cells exhibited increased levels of cobalamin efflux and decreased intracellular accumulation of methyl-cobalamin. There was a clear relationship between the abilities of these related melanoma cell lines to proliferate in methionine-free homocysteine-supplemented medium, and the extent of cobalamin loss and capacity of exogenously added methyl-cobalamin to stimulate in vitro methionine synthase activity. These results indicate a link between alterations in the intracellular trafficking and/or metabolism of cobalamin and the increased growth autonomy of human melanoma cells.
연구논문 : 신뢰와 관계학습이 외식업 프랜차이즈 가맹점의 장기지향성과 관계성과에 미치는 영향 (2009)

This study is to examine structural relationships among trust and relationship learning, theirs antecedents(past transaction satisfaction, reputation, and communication quality), and consequences (long-term orientation, and relationship performance). For these purposes, authors developed several hypotheses. The data were collected from 289 franchisees in foodservice franchise industry context and analyzed with AMOS. The results are as followings: First, trust has significantly positive effect on relationship learning, long-term orientation, and relationship performance. Second, relationship learning has significantly positive effect on long-term orientation, and did not have significantly positive effect on relationship performance. Third, long-term orientation has significantly positive effect on relationship performance. Fourth, past transaction satisfaction has significantly positive effect on trust and long-term orientation. Fifth, reputation has significantly positive effect on trust and relationship learning. Finally, communication quality has significantly positive effect on trust and relationship learning. At the end of this paper, managerial implications, limitations, and future research are discussed.
The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation (1997)

Many functions of the chaperone, heat shock protein 90 (hsp90), are inhibited by the drug geldanamycin that specifically binds hsp90. We have studied an amino-terminal domain of hsp90 whose crystal structure has recently been solved and determined to contain a geldanamycin-binding site. We demonstrate that, in solution, drug binding is exclusive to this domain. This domain also binds ATP linked to Sepharose through the γ-phosphate. Binding is specific for ATP and ADP and is inhibited by geldanamycin. Mutation of four glycine residues within two proposed ATP binding motifs diminishes both geldanamycin binding and the ATP-dependent conversion of hsp90 to a conformation capable of binding the co-chaperone p23. Since p23 binding requires regions outside the 1–221 domain of hsp90, these results indicate a common site for nucleotides and geldanamycin that regulates the conformation of other hsp90 domains.
Mesh-and-Glue Method to Prevent Cerebrospinal Fluid Leakage After Implantation of a Synthetic Dura Mater Substitute: Pressure Resistance and Histologic Studies (2003)

Expanded polytetrafluoroethylene (ePTFE) as a dural substitute is sometimes associated with leakage of cerebrospinal fluid through the suture line. A new procedure—the “mesh-and-glue” (MAG) technique—has been developed by our group to seal the suture line with an absorbable mesh and fibrin glue. The results of preliminary studies to assess the efficacy of this technique using in vitro and in vivo experimental models and its use in clinical situations are reported here. The efficacy of conventional fibrin glue, simple glue spray, MAG, and MAG plus fibrin glue spray was estimated in vitro by measuring the leakage of water through a 1-cm suture line on ePTFE dural substitute. The burst pressures were 4.3 ± 1.2 cm H2O, 64.4 ± 21.4 cm H2O, 142.7 ± 22.2 cm H2O, and 406.1 ± 29.7 cm H2O, respectively, for the different sealing methods and 2.8 ± 0.4 cm H2O for nonsealed controls. Although MAG alone was sufficient to seal a small dural defect, the seal formed when MAG was combined with the glue spray method was sufficiently strong to withstand arterial pressure (300 mm Hg). The type and incidence of long-term pathologic changes associated with MAG were assessed using a murine craniotomy model. Within 2 months of implantation, mesh and fibrin glue was transformed into connective tissue that adhered firmly to the surrounding tissues. These results indicate that MAG will be effective in clinical situations. Given that the seals can withstand arterial pressure, the MAG plus glue spray technique could potentially be used to seal other incisions such as the arachnoid membrane after spinal surgery or the suture line of an arteriotomy in carotid endarterectomy.
Thermoelectric Properties Control due to Doping Level and Sintering Conditions for FGM Thermoelectric Element (1999)

Thermoelectric performance is detennined with three factors, namely, Seebeck coefficient ,electrical resistivity and thermal conductivity. For metal and single crystalline semiconductor, those factors have close interrelation each other. However, as the sintered thermoelectric element has various levels of superstructure from macro scale and micro scale in terms of the thermoelectric mechanism, the relationship among them is more complex than that for the melt-grown element, so it is suggested that the control of the temperature dependence of thermoelectric properties is possible to enhance the thermoelectric performance for wide temperature range due to FGM approach. The research objective is to investigate the characteristics of the thermoelectric properties for various doping levels and hot-pressed conditions to make the thermoelectric elements for which the temperature dependence of the performance is controlled due to FGM approach varying the doping levels and sintering conditions. By usage of the zone traveling hot-press sintering method to Antimony doped magnesium silicide synthesized by the spark plasma sintering method the continuously, functionally graded, sintered thermoelectric bulk element could be successfully made, and the distribution characteristics of thermoelectric properties were satisfactorily measured.
P2-type Na₂/₃Ni₁/₃Mn₂/₃₋ₓTiₓO₂ as a new positive electrode for higher energy Na-ion batteries (2014)

New electrode materials of layered oxides, Na₂/₃Ni₁/₃Mn₂/₃₋ₓTiₓO₂ (0 ≤ x ≤ 2/3), are successfully synthesized, and their electrochemical performance is examined in aprotic Na cells. A Na//Na₂/₃Ni₁/₃Mn₁/₂Ti₁/₆O₂ cell delivers 127 mA h g⁻¹ of reversible capacity and the average voltage reaches 3.7 V at first discharge with good capacity retention.
Electronically Enhanced Remote-Actuation Systems Improve Deepwater Completions and Capabilities (1997)

Summary With offshore rig demand at a premium and costs often exceeding U.S. $100,000/D, the economics of developing burgeoning deep-water arenas is closely tied to technologies that expedite production and reduce rig time. This paper describes a new, mud-pulse-frequency-based communication technique that actuates and manipulates downhole tools equipped with onboard electronics. The down-hole tools (which may include permanent or retrievable packers and sliding sleeves) are programmed at the surface to recognize one of 16 discrete actuation commands from a computer-controlled, portable terminal unit. Once in position, the tools are actuated upon receipt of a specific command sent from the portable terminal unit. As many as 16 devices can be actuated independently of one another in a single wellbore; and, because the system is independent of absolute pressure in the tubing, there is no need to install, for example, a tubing plug to set a packer. By using packers equipped for electronically enhanced remote actuation, days of rig time can be saved by accelerating the completion cycle. Sliding sleeves equipped with the new technology can be remotely shifted without using coiled tubing or wireline. Electronically enhanced remote actuation allows for reduction, and in some cases total elimination, of common well-intervention operations associated with getting the initial completion in the ground. The resulting savings in operating expense and overall completion cost can be substantial, as has been proved in several recent deepwater applications.
Stereospecific Synthesis of (+)-β-Sesquiphellandrene (1999)

The structure and absolute configuration of (−)-β-Sesquiphellandrene ((−)-1a) is shown to be (6S)-2-methyl-6-[(1′R)-4-methylidenecyclohex-2-enyl]hept-2-ene by stereospecific synthesis of its enantiomer ((+)-1a) and of a further (6S,1′S)-diastereoisomer ((+)-1b). Characteristic spectroscopic differences in both diastereoisomeric series are discussed.
The Effect of Contact Lens Wear on the Central and Peripheral Corneal Endothelium (2000)

Central ECD was significantly higher by 3% than peripheral ECD in normal subjects, but not in contact lens wearers. The results suggest that contact lens wear causes a mild redistribution of endothelial cells from the central to the peripheral cornea. A reversal of this redistribution after contact lens wear is discontinued for refractive surgery could mask mild central endothelial damage from the refractive procedure.
A general quantitative cryptanalysis of permutation-only multimedia ciphers against plaintext attacks. (2004)

In recent years secret permutations have been widely used for protecting different types of multimedia data, including speech files, digital images and videos. Based on a general model of permutation-only multimedia ciphers, this paper performs a quantitative cryptanalysis on the performance of these kind of ciphers against plaintext attacks. When the plaintext is of size MxN and with L different levels of values, the following quantitative cryptanalytic findings have been concluded under the assumption of a uniform distribution of each element in the plaintext: (1) all permutation-only multimedia ciphers are practically insecure against known/chosen-plaintext attacks in the sense that only O(log_L(MN)) known/chosen plaintexts are sufficient to recover not less than (in an average sense) half elements of the plaintext; (2) the computational complexity of the known/chosen-plaintext attack is only O(n(MN)^2), where n is the number of known/chosen plaintexts used. When the plaintext has a non-uniform distribution, the number of required plaintexts and the computational complexity is also discussed. Experiments are given to demonstrate the real performance of the known-plaintext attack for a typical permutation-only image cipher.