gebhart/patrepeval huggingface dataset:
Systematic analysis of ATG13 domain requirements for autophagy induction (2017)

Macroautophagy/autophagy is an evolutionarily conserved cellular process whose induction is regulated by the ULK1 protein kinase complex. The subunit ATG13 functions as an adaptor protein by recruiting ULK1, RB1CC1 and ATG101 to a core ULK1 complex. Furthermore, ATG13 directly binds both phospholipids and members of the Atg8 family. The central involvement of ATG13 in complex formation makes it an attractive target for autophagy regulation. Here, we analyzed known interactions of ATG13 with proteins and lipids for their potential modulation of ULK1 complex formation and autophagy induction. Targeting the ATG101-ATG13 interaction showed the strongest autophagy-inhibitory effect, whereas the inhibition of binding to ULK1 or RB1CC1 had only minor effects, emphasizing that mutations interfering with ULK1 complex assembly do not necessarily result in a blockade of autophagy. Furthermore, inhibition of ATG13 binding to phospholipids or Atg8 proteins had only mild effects on autophagy. Generally, the observed phenotypes were more severe when autophagy was induced by MTORC1/2 inhibition compared to amino acid starvation. Collectively, these data establish the interaction between ATG13 and ATG101 as a promising target in disease-settings where the inhibition of autophagy is desired.
'Him a 'Got Too Much Skin': Psoriatic Masculinity and the Singing Detective (2007)

Although hysteria has traditionally been the purview of femininity, the male hysteric has become more prevalent under the social and cultural conditions of postmodernity, namely, the delegitimation and fragmentation of identity. This article reads the central trope of psoriasis in Dennis Potter’s television mini-series The Singing Detective as a corporeal symptom that ambivalently reflects, and resists, the economic and social context of Thatcherite Britain. Philip Marlow’s psoriasis enacts both the erosion and the overproduction of boundaries, and is read as metonymic for a male social body that is being experienced as under siege.
Real-time dynamic control of an industrial manipulator using a neural network-based learning controller (1990)

A learning control technique that uses an extension of the cerebellar model articulation control network developed by J.S. Albus (1975) is discussed, and results of real-time control experiments that involved learning the dynamics of a five-axis industrial robot (General Electric P-5) during high-speed movements are presented. During each control cycle, a training scheme was used to adjust the weights in the network in order to form an approximate dynamic model of the robot in appropriate regions of the control space. Simultaneously, the network was used during each control cycle to predict the actuator drives required to follow a desired trajectory, and these drives were used as feedforward terms in parallel to a fixed-gain linear feedback controller. Trajectory tracking errors were found to converge to low values within a few training trials, and to be relatively insensitive to the choice of control system gains. The effects of network memory size and trajectory characteristics on learning system performance were investigated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Automated variability injection for graphical modelling languages (2020)

© ACM 2020. This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in International Conference on Generative Programming: Concepts and Experiences, https://doi.org/10.1145/3425898.3426957
Fabrication of microvessels and microlenses from polymers by solvent droplets (2005)

A process for the fabrication of microvessels and microlenses in polymers is presented. A drop of solvent (diameter between 15 and 150μm) is deposited by an ink-jet method onto a flat polymer substrate. After evaporation of the solvent a lenticular cavity of dimensions comparable to the former drop size is created. This cavity can be employed as a microreaction vessel, as a concave lens, or as a template for a convex lens. Diameter, depth, position, and arrangement of the microvessels on the surface can be controlled.
GYKI 52466 blocks the increase in extracellular glutamate induced by ischaemia (1992)

In vivo microdialysis has been used to study the effect of pre- or post-ischaemic administration of the non-NMDA antagonist 1-(4-amino-phenyl)-4-methyl-7, 8-methyl-endioxyl-5H-2,3- benzodiazepine hydrochloride (GYKI 52466), on the increases in extracellular glutamate levels induced by 20 minutes of four vessel occlusion in rats. In control rats, ischaemia resulted in transient increases in glutamate (4 fold), aspartate (6 fold) and gamma-aminobutyric acid (GABA) (15 fold) and decreases in glutamine (0.5 fold). Intravenous administration of GYKI 52466 (10 mg kg-1 bolus followed by 10 mg kg-1 h-1 infusion) beginning 20 minutes prior to the induction of ischaemia abolished ischaemia-induced glutamate release without affecting the increases in aspartate and GABA and the decrease in glutamine. Administration of GYKI 52466 immediately post-ischaemia resulted in a more rapid return of glutamate levels to basal values.
Permanent Bubble Arrays from a Cross-Linked Poly(<i>p</i><i>ara-</i>phenyleneethynylene):  Picoliter Holes without Microfabrication (2004)

An azide-substituted poly(para-phenyleneethynylene) (PPE) 4 was prepared by the Heck-Cassar-Sonogashira-Hagihara method. Thin films of 4 form self-assembled bubble arrays from carbon disulfide solution utilizing the breath figure method. The as-formed porous films of 4 are soluble in common solvents, and the air bubbles are interconnected. Upon heating to 300 degrees C, 4 cross-links and the thin film turn into insoluble matrix with isolated bubbles. The cross-linking process has transformed the bubble arrays of 4 into insoluble picoliter beakers or picoliter vials, whose diameters are approximately 3.0 and 1.5 mum at the top and bottom, respectively.
Improvements in the osmium-catalyzed oxyamination of olefins by chloramine-T (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImprovements in the osmium-catalyzed oxyamination of olefins by chloramine-TEugenio Herranz and K. Barry SharplessCite this: J. Org. Chem. 1978, 43, 12, 2544–2548Publication Date (Print):June 1, 1978Publication History Published online1 May 2002Published inissue 1 June 1978https://doi.org/10.1021/jo00406a057Request reuse permissionsArticle Views576Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (701 KB) Get e-Alertsclose Get e-Alerts
Fungal products. Part V. The absolute stereochemistry of colletodiol and the structures of related metabolites of Colletotrichum capsici (1973)

Colletoketol (2), colletol (3), and colletallol (4), three new co-metabolites of colletodiol (1)(10,11-dihydroxy-2,8-dimethyl-1,7-dioxacyclotetradeca-4,12-diene-6,14-dione), have been isolated from culture filtrates of Colletotrichum capsici and shown to be the 11-oxo-analogues of colletodiol, 11-deoxycolletodiol, and 10-deoxy-colletodiol, respectively. The absolute stereochemistry for colletodiol [i.e.(2R,8R,10R,11S)] has been assigned from chemical and optical rotatory evidence, and that for colletoketol [i.e.(2R, 8R,10R)] has been established by chemical correlation with colletodiol.
<i>Relationship of Platelet Factor 1 and Platelet Fibrinogen to Plasma</i> (1958)

Some platelet factors appear, in the light of our present knowledge, to be characterized by activities similar to those in plasma. These platelet activities may be simply ‘artifacts, ’ or a useful and necessary function in the blood coagulation mechanisms may be served by having the activity reside in both plasma and platelets. Two such activities are platelet factor 1 (accelerator) and platelet fibrinogen or clottable factor. The role of platelet factor 1 is somewhat clarified by the fact that a normal prothrombin consumption time was found in the absence of plasma Ac-globulin and platelet factor 1. These same platelets which lacked platelet factor 1 were able to pick up Ac-globulin from normal plasma. In another case, the concentration of platelet fibrinogen appeared to be independent of the concentration of plasma fibrinogen, suggesting that these two types of fibrinogen may have some significant difference. Submitted on April 30, 1958
Looks Good To Me (2016)

Augmented reality is poised to become a dominant computing paradigm over the next decade. With promises of three-dimensional graphics and interactive interfaces, augmented reality experiences will rival the very best science fiction novels. This breakthrough also brings in unique challenges on how users can authenticate one another to share rich content between augmented reality headsets. Traditional authentication protocols fall short when there is no common central entity or when access to the central authentication server is not available or desirable. Looks Good To Me (LGTM) is an authentication protocol that leverages the unique hardware and context provided with augmented reality headsets to bring innate human trust mechanisms into the digital world to solve authentication in a usable and secure way. LGTM works over point to point wireless communication so users can authenticate one another in a variety of circumstances and is designed with usability at its core, requiring users to perform only two actions: one to initiate and one to confirm. Users intuitively authenticate one another, using seemingly only each other's faces, but under the hood LGTM uses a combination of facial recognition and wireless localization to bootstrap trust from a wireless signal, to a location, to a face, for secure and usable authentication.
Field validation of a semi-spherical Lagrangian drifter (2001)

We present the design and field validation for the performance of a Semi-spherical Lagrangian Drifter (SELD). The SELD is a low-cost, low-technology, home-made alternative to much more expensive commercial Lagrangian drifters. An analysis of the SELD configuration shows that its drag area ratio is as good as TRISTAR and holey-sock drifters. Field results in a situation of near solid rotation within an oceanic vortex confirm that SELD and holey-sock drifters have an almost identical behavior.
Run-and-pause dynamics of cytoskeletal motor proteins (2016)

Cytoskeletal motor proteins are involved in major intracellular transport processes which are vital for maintaining appropriate cellular function. When attached to cytoskeletal filaments, the motor exhibits distinct states of motility: active motion along the filaments, and pause phase in which it remains stationary for a finite time interval. The transition probabilities between motion and pause phases are asymmetric in general, and considerably affected by changes in environmental conditions which influences the efficiency of cargo delivery to specific targets. By considering the motion of individual non-interacting molecular motors on a single filament as well as a dynamic filamentous network, we present an analytical model for the dynamics of self-propelled particles which undergo frequent pause phases. The interplay between motor processivity, structural properties of filamentous network, and transition probabilities between the two states of motility drastically changes the dynamics: multiple transitions between different types of anomalous diffusive dynamics occur and the crossover time to the asymptotic diffusive or ballistic motion varies by several orders of magnitude. We map out the phase diagrams in the space of transition probabilities, and address the role of initial conditions of motion on the resulting dynamics.
Dissociation between Epitope Hierarchy and Immunoprevalence in CD8 Responses to Vaccinia Virus Western Reserve (2008)

Understanding immunity to vaccinia virus (VACV) is important for the development of safer vaccines for smallpox- and poxvirus-vectored recombinant vaccines. VACV is also emerging as an outstanding model for studying CD8(+) T cell immunodominance because of the large number of CD8(+) T cell epitopes known for this virus in both mice and humans. In this study, we characterize the CD8(+) T cell response in vaccinated BALB/c mice by a genome-wide mapping approach. Responses to each of 54 newly identified H-2(d)-restricted T cell epitopes could be detected after i.p. and dermal vaccination routes. Analysis of these new epitopes in the context of those already known for VACV in mice and humans revealed two important findings. First, CD8(+) T cell epitopes are not randomly distributed across the VACV proteome, with some proteins being poorly or nonimmunogenic, while others are immunoprevalent, being frequently recognized across diverse MHC haplotypes. Second, some proteins constituted the major targets of the immune response by a specific haplotype as they recruited the majority of the specific CD8(+) T cells but these proteins did not correspond to the immunoprevalent Ags. Thus, we found a dissociation between immunoprevalence and immunodominance, implying that different sets of rules govern these two phenomena. Together, these findings have clear implications for the design of CD8(+) T cell subunit vaccines and in particular raise the exciting prospect of being able to choose subunits without reference to MHC restriction.
Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. I (1955)

Based on the fact that a part of the morphine skeleton contains a decahydroisoquinoline ring, some hydroisoquinolines of such series and related hydroquinoline derivatives were studied in connection with the analgesic action that might be shown by these compounds. As a preliminary, 10-phenyl- and 10-anisyldecahydroquinolines were prepared by the high pressure catalytic reduction of 2-substituted 2-(β-cyanoethyl)-cyclohexane and 8-cyclohexyldecahydroquinoline by the same procedure from 6-cyclohexylidene-2-(β-cyanoethyl)-cyclohexanone. The N-alkyl derivatives were totally devoid of or possessed only a weak analgesic action.
IDEA Software Case Study (2019)

Our case study is designed for students to use IDEA Software, a prominent audit software used by large accounting firms to find fraudulent data by running different tests. These tests can vary from analyzing abnormally large transactions to looking for collusion between employees to using Benford's Law.
A new level of social search: discovering the user’s opinion before he can make one (2011)

Current approaches to social search are generally based on the friends’ opinion and collaborative filtering paradigms, which have limited effectiveness in terms of both accuracy and coverage of the information that may be relevant to a user. We propose a new kind of social search signal, based on the idea of prediction extraction, which is aimed at improving the quality of information available to current methods, as well as introducing new kinds of search methods.
MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks (2010)

PALB2 physically and functionally connects the proteins encoded by the BRCA1 and BRCA2 breast and ovarian cancer genes into a DNA-damage-response network. However, it remains unclear how these proteins associate with chromatin that contains damaged DNA. We show here that PALB2 binds directly to a conserved chromodomain protein, MRG15, which is a component of histone acetyltransferase-deacetylase complexes. This interaction was identified by analysis of purified MRG15- and PALB2-containing protein complexes. Furthermore, MRG15 interacts with the entire BRCA complex, which contains BRCA1, PALB2, BRCA2 and RAD51. Interestingly, MRG15-deficient cells, similarly to cells deficient in PALB2 or BRCA2, showed reduced efficiency for homology-directed DNA repair and hypersensitivity to DNA interstrand crosslinking agents. Additionally, knockdown of MRG15 diminished the recruitment of PALB2, BRCA2 and RAD51 to sites of DNA damage and reduced chromatin loading of PALB2 and BRCA2. These results suggest that MRG15 mediates DNA-damage-response functions of the BRCA complex in chromatin.
D-Bus based user device driver framework design for Linux mobile software platform (2009)

Mobile phone manufacturing companies wish to use a software development platform based on Linux for application security and software development efficiency. The Linux platform development confers stability. The driver code for each device should be inserted in Linux kernel to run the hardware devices of the mobile phones. Applications must request device control from the driver kernel using a specified access interface. In these structures, the stability of the mobile phone system depends on the developer's skill. Therefore, developers must make appropriate use of the driver code to be activated in the Linux kernel. They should design the programming interface to be reliable, correct and robust, so applications can be easily ported. Therefore, we ported the device driver code from the Linux kernel to the user area. We designed a driver framework based on the D-bus in user area. Most of driver code in the user area and application can access the device passing D-bus interface the driver framework offers. Therefore, we could improve system stability.
Morphological and secretory properties of bronchoalveolar lavage mast cells in respiratory diseases (1986)

Summary We have studied various functional and morphological characteristics of mast cells obtained in bronchoalveolar lavage from fifty‐two patients with several lung diseases. The percentage of mast cells ranged from 0.04 to 0.6% (bronchial carcinoma). 0.05–0.3% (sarcoidosis), 0.06–0.25% (asthma), 0.04–1.8% (miscellaneous) and 0.02–0.04% (normals). There were no significant differences in the mast cell counts between the disease groups. Lung mast cells exhibited heterogeneity of size, shape and intensity of staining. Cells from thirty‐seven subjects were further studied for total histamine content and histamine release using various secretagogues. There was a significant correlation ( P <0.001) between the histamine content of the total lavage cell population and mast cell counts. The calculated mean histamine content per mast cell was 6.35 pg. Histamine was released in a dose‐dependent fashion after stimulation with anti‐IgE, calcium ionophore and phorbol myristate acetate with a time course of histamine release characteristic of the mast cell. Unlike peripheral blood basophils, no release was observed following incubation with f‐met‐leu‐phe (10 −6 ‐10 −8 m ) and neither cell type released histamine following incubation with 48/80 (10 μg/ml). Inhibition of anti‐IgE‐induced histamine release was obtained following pre‐incubation with salbutamol (10 −4 ‐10 −6 m ). These studies indicate that bronchoalveolar lavage is a suitable model for the study of human lung mast cells.
Impedance spectroscopy of organic hetero-layer OLEDs as a probe for charge carrier injection and device degradation (2009)

Impedance spectroscopy (IS) is a powerful method for characterizing the electrical properties of materials and their interfaces. In this study we use IS to investigate the charge carrier injection properties of different anodes and anode treatments in bottom-emitting organic light-emitting diodes (OLEDs). These are ITO-based (indium tin oxide) hetero-layer devices with TPD (N,N'-diphenyl-N,N'-bis(3-methylphenyl)-1,1'-biphenyl-4,4-diamine) as hole transporting layer (HTL) and Alq<sub>3</sub> (tris-(8-hydroxyquinoline) aluminum) as emission and electron transporting layer (EML and ETL, respectively). A detailed analysis of the capacitance as function of frequency and DC bias yields information about trapped and interfacial charges as well as the dynamics of injected charges. Furthermore, we use IS to study degradation processes in OLEDs.
EFFECTS OF BLOOD FLOW ON SKIN HEATING INDUCED BY MILLIMETER WAVE IRRADIATION IN HUMANS (2004)

We have previously reported species differences in the rate of skin heating in response to millimeter wavelength microwave exposure. We hypothesized that these differences were predominantly a function of species differences in the ability to increase skin blood flow during local heating. Mathematical modeling also suggested that, in humans, the rate of skin heating during prolonged millimeter wavelength exposure would be dependent on skin blood flow. In order to empirically test this hypothesis, we determined the role of baseline skin blood flow on the rate of cutaneous heating induced by 94-GHz microwave energy in humans (3 female, 3 male) using infrared thermography and laser Doppler imaging to measure skin temperature and relative skin blood flow, respectively. Millimeter wavelength exposure intensities used were high power (HP), 1 W x cm(-2) for 4 s and low power, 175 mW cm(-2) for 180 s. Skin blood flow was (a) normal, (b) eliminated using a blood pressure cuff to occlude forearm blood flow, or (c) elevated by heating the skin prior to irradiation. Results showed that for the HP exposures, these manipulations did not influence the rate of skin heating. For the low power exposures, occlusion of baseline skin blood flow had a small impact on the subsequent rate of heating. In contrast, a two-fold elevation in baseline skin blood flow had a profound impact on the subsequent rate of heating, resulting in a substantially lower rate of heating. Occlusion of an elevated skin blood flow reversed this lower rate of heating. The results of these studies demonstrate that relatively small changes in skin blood flow may produce substantial alterations in the rate of skin heating during prolonged 94-GHz exposure.
Approaches to enhancing the sensitivity of capillary electrophoresis methods for the determination of inorganic and small organic anions (2001)

One of the major problems facing the development of capillary electrophoresis (CE) is the relatively high limits of detection when compared to traditional high-performance liquid chromatographic (HPLC) methods. While the use of an alternative detector can offer better sensitivity, a more universal approach is sample preconcentration. Numerous on-line methods have been developed to improve the sensitivity of CE, and are based on electrophoretic principles, chromatographic principles, or a combination of both. This review will discuss all forms of on-line preconcentration methods for CE, with emphasis given to those that have shown particular merit when applied to inorganic and small organic anions.