gebhart/patrepeval huggingface dataset:
The GaAs dual-gate FET with low noise and wide dynamic range (1973)

The benefits inherent in the tetrode structure and the potential of GaAs as the material are combined to realize a dual-gate FET with a low noise figure and a wide dynamic range at microwave frequencies. Following the newly constructed design theory of GaAs dual-gate FET, an improved device structure is derived and FET's are fabricated using a Schottky barrier for the gate. The improved device exhibited a noise figure as low as 3dB and a power gain of 12dB at 4GHz. The stability factor and maximum stable gain are much larger than the single gate unit. By varying the 2nd gate bias, the power gain was controllable over a wide range of 30dB at 4GHz without significantly affecting the input impedance.
YM‐53601, a novel squalene synthase inhibitor, suppresses lipogenic biosynthesis and lipid secretion in rodents (2003)

1. To better understand how it decreases plasma cholesterol and triglyceride levels, we evaluated the effect of (E)-2-[2-fluoro-2-(quinuclidin-3-ylidene)ethoxy]-9H-carbazole monohydrochloride(YM-53601) on lipogenic biosynthesis in the liver and lipid secretion from the liver in rats and hamsters. 2. Single administration of YM-53601 in cholestyramine-treated rats inhibited triglyceride and free fatty acid (FFA) biosynthesis at a similar dose range to that at which it inhibited cholesterol biosynthesis. YM-53601 inhibited both triglyceride and FFA biosynthesis in hamsters treated with cholestyramine. 3. YM-53601 by single oral administration decreased the enhanced plasma triglyceride levels in hamsters induced by an injection of protamine sulfate, which inhibits lipoprotein lipase (LPL) and consequently increases plasma very low-density lipoprotein (VLDL) triglyceride levels. YM-53601 also decreased the enhanced plasma triglyceride and cholesterol levels in hamsters treated with Triton WR1339, which also inhibits the degradation of VLDL. Plasma cholesterol was significantly decreased as soon as 1 h after single administration of YM-53601 in hamsters fed a normal diet. 4. This is the first report that a squalene synthase inhibitor suppresses lipogenic biosynthesis in the liver and cholesterol and triglyceride secretion from the liver in vivo. We therefore suggest that the mechanism by which YM-53601 decreases plasma triglyceride might include these effects. The finding that YM-53601 rapidly decreased plasma cholesterol suggests that this compound may be effective in decreasing plasma cholesterol levels early in the course of treatment of hypercholesterolemia in humans.
Sequential monte carlo methods for multi-target filtering with random finite sets (2005)

Random finite sets (RFSs) are natural representations of multitarget states and observations that allow multisensor multitarget filtering to fit in the unifying random set framework for data fusion. Although the foundation has been established in the form of finite set statistics (FISST), its relationship to conventional probability is not clear. Furthermore, optimal Bayesian multitarget filtering is not yet practical due to the inherent computational hurdle. Even the probability hypothesis density (PHD) filter, which propagates only the first moment (or PHD) instead of the full multitarget posterior, still involves multiple integrals with no closed forms in general. This article establishes the relationship between FISST and conventional probability that leads to the development of a sequential Monte Carlo (SMC) multitarget filter. In addition, an SMC implementation of the PHD filter is proposed and demonstrated on a number of simulated scenarios. Both of the proposed filters are suitable for problems involving nonlinear nonGaussian dynamics. Convergence results for these filters are also established.
Fabrication of stretchable and flexible electrodes based on PDMS substrate (2012)

We developed a simple and reliable fabrication method to realize electrically and mechanically stable stretchable and flexible metal patterns based on PDMS substrate using an intermediate thin film layer. The mechanical and electrical stability of the fabricated electrodes were characterized under dynamic/static bending and stretching deformation on a custom-designed test module and a push pull gage tester. Also the adhesion between contact layers such as PDMS, parylene and metal layers was evaluated using adhesion tape test method. Based on these results, we believe that the proposed fabrication method would contribute to flexible electronics and MEMS applications.
Low-cost realtime screen sharing to multiple clients (2010)

In this paper, we propose an efficient encoding solution for the screen-sharing applications with multiple clients connected. We first present a lightweight screen codec to compress the complicated screen content. Based on the architecture of the proposed codec, we propose a one-pass encoding algorithm for multiple bit-rates. The one-pass encoding algorithm enables the host to only involve in one-pass encoding process for multiple bitrates, and as a result the computation complexity of the host is decreased significantly. Specially, in the limited computing-resource case, the one-pass encoding algorithm can improve the screen-sharing performance by about 43%, in terms of framerates the clients can get. In addition, based on our codec, we propose a fast screen transcoding scheme for the data-center based screen-sharing applications.
Transmit Diversity via Oscillating-Beam-Pattern Adaptive Antennas: An Evaluation Using Geometric-Based Stochastic Circular-Scenario Channel Modeling (2004)

Applying carefully-selected time-varying phases (delays) to array elements of an adaptive antenna, the beam pattern oscillates in a controlled manner. This creates a time varying channel with a controllable coherence time. With an adaptive antenna at the base station (BS) and a single omnidirectional antenna at the mobile, the controllable coherence time is used by the mobile to exploit time diversity and enhance performance. In this work, assuming an oscillating-beam-pattern antenna array at the BS, the channel is properly modeled and the coherence time is evaluated. A so-called geometric-based stochastic channel model is presented, assuming a circular coverage area, and the channel is simulated in an urban environment. We demonstrate the relationship between coherence time and the antenna array control parameters and show that seven-fold-diversity can be created via small beam pattern oscillation.
Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis (2009)

The aim of this study was to investigate the expressions of Toll-like receptor (TLR) 2, TLR4, TLR9, and their correlations with the expression of cytokines that are associated with activation of CD4(+) T cells and inflammation including interferon gamma (IFNgamma), interleukin 4 (IL4), interleukin 17 (IL17), and tumor necrosis factor alpha (TNFalpha) in muscle tissues of patients with dermatomyositis (DM) and polymyositis (PM). The expressions of TLR2, TLR4, TLR9, IFNgamma, IL4, IL17, and TNFalpha were measured by real-time reverse transcription-polymerase chain reaction in muscle tissues from 14 patients with DM and PM (nine patients with DM, five patients with PM) and three controls. The expressions of TLR2, TLR4, and TLR9 were also localized with immunohistochemistry. The expression levels of TLR2, TLR4, TLR9, IFNgamma, IL4, IL17, and TNFalpha were significantly high in patients with DM and PM compared with those in the controls, and the expression levels of TLR4 and TLR9 had significant positive correlations with the expressions of IFNgamma, IL4, IL17, and TNFalpha. Immunohistochemistry showed that TLR2, TLR4, and TLR9 were expressed by infiltrating cells of perimysium in DM, whereas they were expressed by infiltrating cells of endomysium in PM. These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells.
Establishment and application of a real-time loop-mediated isothermal amplification system for the detection of CYP2C19 polymorphisms (2016)

Single-nucleotide polymorphisms (SNPs) represent the most widespread type of genetic variation (approximately 90%) in the human genome, and the demand to overcome such variation has received more attention now than ever before. The capacity to rapidly assess SNPs that correlate with disease predisposition, drug efficacy and drug toxicity is a key step for the development of personalized medicine. In this work, a rapid one-step SNP detection method, real-time loop-mediated isothermal amplification (RT-LAMP), was first applied for CYP2C19 polymorphisms testing. The optimized method was established with specifically designed primers for target amplification by real-time detection in approximately 30 min under isothermal conditions. RT-LAMP amplified few copies of template to produce significant amounts of product and quantitatively detected human DNA with compatible specificity and sensitivity. The success in the establishment of this RT-LAMP protocol for CYP2C19 polymorphism testing is significant for the extension of this technique for the detection of other SNPs, which will further facilitate the development of personalized medicine.
GaInAsP/InP zero-gap directional couplers as compact optical WDM filters (1989)

The fabrication and characterisation of extremely compact WDM zero-gap directional couplers with buried GaInAsP/InP waveguides is reported. A device with a centre length of 178 µm separated two channels at λ1 = 1.3 µm and λ2 = 1.52 µm with a crosstalk attenuation of 30 dB.
A Phase IA/IB Trial of Anti-CD3 Murine Monoclonal Antibody plus Low-Dose Continuous-Infusion Interleukin-2 in Advanced Cancer Patients (1995)

Summary: Preclinical studies have shown that anti-CD3 antibodies can enhance the in vitro activation of human T lymphocytes in combination with low-dose interleukin-2 (IL-2) and induce the in vivo rejection of murine tumors. A Phase IA/IB trial combining a murine monoclonal antibody, anti-CD3 antibody (OKT3), with low-dose continuous-infusion IL-2 was conducted in cancer patients to define the toxicity and immunologic effects of this combination. OK.T3 administered weekly as a 15-min infusion at dose levels of 10, 100, 200, 400, and 600 μg/m2 was followed 18 h later by a 100-h infusion of IL-2 at 3 MIU/m2/day for 3 consecutive weeks. When feasible, patients also received the IL-2 course without OKT3 to assess the effects of OKT3 on the IL-2 regimen within the same patient. Thirty patients were enrolled onto the study, with 24 completing the OKT3/IL-2 course and 18 completing both OKT3/IL-2 and IL-2 alone courses. OKT3 administration was associated with acute hypotension with fevers of >40°C and in two patients cerebral vascular infarcts. At 600 μg/m2 OKT3, these toxicities were dose limiting. In a dose-dependent manner, OKT3 induced the transient release of tumor necrosis factor (TNF) and IL-6 into the serum and a profound lymphopenia. OKT3 did not significantly enhance the toxicity of this schedule of IL-2 administration. All solid tumor patients treated at 100-600 μg/m2 OKT3 showed induction of a human anti-murine antibody response prior to the third week of treatment. A patient with renal cell cancer treated at the 600-μg/m2 OKT3 dose level experienced a 4-month partial remission, and two mixed responses were observed in a sarcoma and a melanoma patient treated at 100- and 400-μg/m2 OKT3 dose levels, respectively. Most importantly, we were unable to demonstrate that the addition of OKT3 enhanced immune activation within peripheral blood based upon the magnitude of rebound lymphocytosis, increase in CD56+ or CD3 +, CD25 + lymphocytes, induction of natural killer, lymphokine activated killer, or cytolytic T lymphocyte cytotoxicity, or release of serum cytokines (TNF, IL-6) or soluble CD25 (as assayed 24 h following IL-2 infusion). Therefore, this approach was ineffective at enhancing the immunologic effects of a low-dose continuous-infusion IL-2 regimen and will not be pursued further in clinical trials.
A large area reconfigurable MOEMS microshutter array for coded aperture imaging systems (2008)

Coded aperture imaging has been used for astronomical applications for several years. Typical implementations used a fixed mask pattern and are designed to operate in the X-Ray or gamma ray bands. Recently applications have emerged in the visible and infra red bands for low cost lens-less imaging systems and system studies have shown that considerable advantages in image resolution may accrue from the use of multiple different images of the same scene - requiring a reconfigurable mask. Previously we reported on the early feasibility of realising such a mask based on polysilicon micr-opto-electromechanical systems (MOEMS) technology and early results in the visible and near IR bands. This employs interference effects to modulate incident light - achieved by tuning a large array of asymmetric Fabry-Perot optical cavities via an applied voltage whilst a hysteretic row/column addressing scheme is used to control the state of individual elements. In this paper we present transmission results from the target mid-IR band (3-5μm), compare them with theory and describe the scale up from a 3x3 proof-of-concept MOEMS microshutter array to a 560 x 560 element array (2cm x 2cm chip) with the associated driver electronics and embedded control - including aspects of electronic design, addressing control and integration. The resultant microsystem represents a core building block to realise much larger reconfigurable masks using a tiled approach with further integration challenges in the future.
Reconstruction of thoracic esophagus with pediculated diaphragmatic flap in dogs (2007)

The diaphragmatic flaps are suitable on the restoring of continuity in dog's thoracic esophagus.
Effect of combined therapy with phosphate and calcitonin on bone volume in osteoporosis (1980)

Twenty-six patients with postmenopausal osteoporosis were randomly divided into three treatment groups and were then treated for a period of six months with either : 1) double placebo ; II) oral placebo and parenteral calcitonin ; or III) oral phosphate and parenteral calcitonin. The study was carried out with a double blind protocol. Bone biopsies were obtained before and after the period of treatment and quantitative histomorphometry was performed on these biopsies by two independent observers. The results show that in patients in groups I and 11 there was no significant change In trabecular bone mass or In bone remodeling parameters. However, patients in group III showed a 36 percent increase in trabecular bone mass and an 85 percent increase in extent of bone formation surface without a significant Increase In either osteoclast count or extent of bone resorption surface. In treatment group III plasma immunoreactive PTH also rose significantly. Vingt-six patientes atteintes d'ostéoporose post-ménopausique ont été divisées au hasard en trois groupes traités pendant une péiods de six mois avec suit l) double placebo, soit 11) placebo oral et calcitonine parentérale, soit III) phosphate oral et calcitonine parentéralse, de manibre séquentielle. L'étude a été menée suivant un protocols on double aveugle. Des biopsies osseuses ont été prélevées avant et aprbs to periods de traitement et I'histomorphométrie réalisée per deux observateurs independents. Les résuhats montrent l'absence de changements significatifs du volume trabéculaire osseux et des paramètres du remaniement chez les patientes des groupes I et II. Par contre, les patientes du groups 111 ont montré une augmentation de 36%/o de lour volume trabéculaire osseux et une augmentation de 85% de la surface osseuse en formation sans changements significatifs du nombre d'ostéoclastes ou de ('extension de la surface osseuse en résorption. 11 a aussi été observe dans ce groupe une augmentation significative de la PTH immunoréactive.
Nomilin, a new bitter component in grapefruit juice (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNomilin, a new bitter component in grapefruit juiceRussell L. RouseffCite this: J. Agric. Food Chem. 1982, 30, 3, 504–507Publication Date (Print):May 1, 1982Publication History Published online1 May 2002Published inissue 1 May 1982https://pubs.acs.org/doi/10.1021/jf00111a022https://doi.org/10.1021/jf00111a022research-articleACS PublicationsRequest reuse permissionsArticle Views286Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Virtual Screening to Successfully Identify Novel Janus Kinase 3 Inhibitors: A Sequential Focused Screening Approach (2008)

In an effort to identify novel Janus kinase 3 inhibitors, a sequential focused screening approach was adopted to search our in-house chemical database. By biologically testing only 79 selected compounds, we successfully identified 19 compounds showing IC 50 < 20 microM, with four of them in the nanomolar range. Particularly, a 3,5-disubstituted pyrazolo[4,3- d]pyrimidine scaffold emerged as a promising candidate for further lead optimization. With the advantages of efficiency and flexibility, this approach may be utilized to identify leads for other therapeutic targets.
Origin of the Milk Fat Globule Membrane (1971)

Compositional analyses of milk fat globule membrane revealed that it differs from plasma membranes chiefly in that it contains higher levels of neutral lipids, particularly triglycerides. Previous work has shown that phospholipids and proteins of the fat globule and plasma membranes are virtually identical. Electron microscopic examination revealed a layer of material bound to one face o the isolated milk fat globule membrane. This bound material appears to be neutral lipid derived from the fat globule. This neutral lipid coating along one face of the membrane appears to be responsible for the morphological and compositional differences observed between the milk fat globule membrane and plasma membrane.
Deep submicrometer super self-aligned Si bipolar technology with 25.4 ps ECL (1994)

A new deep submicron double-poly self-aligned Si bipolar technology has been developed using a 0.3-/spl mu/m design rule, a collector polysilicon trench electrode, and oxide-filled trench isolation. This technology is called "High-Performance Super Self-Aligned Process Technology" or HSST. 0.3-/spl mu/m minimum patterning is achieved by electron-beam direct writing technology. The HSST bipolar transistor is 2.5 times smaller than the previous 1-/spl mu/m SST-1B. Owing to its horizontal reduction and an f/sub T/ of 22.3 GHz at V/sub ce/=1 V, the ECL gate attains 25.4 ps/G at 1.58 mA, which is a 30% improvement on the SST-1B. By including parasitic capacitances of the base polyelectrode and polyresistors, the ECL delay time is accurately simulated for low-power operation. It is shown that the HSST is a very promising technology for the development of future high-speed communication systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Synthesis of 2-arylindole derivatives and evaluation as nitric oxide synthase and NFκB inhibitors (2012)

Development of small molecule drug-like inhibitors blocking both nitric oxide synthase and NFκB could offer a synergistic therapeutic approach in the prevention and treatment of inflammation and cancer. During the course of evaluating the biological potential of a commercial compound library, 2-phenylindole (1) displayed inhibitory activity against nitrite production and NFκB with IC(50) values of 38.1 ± 1.8 and 25.4 ± 2.1 μM, respectively. Based on this lead, synthesis and systematic optimization have been undertaken in an effort to find novel and more potent nitric oxide synthase and NFκB inhibitors with antiinflammatory and cancer preventive potential. First, chemical derivatizations of 1 and 2-phenylindole-3-carboxaldehyde (4) were performed to generate a panel of N-alkylated indoles and 3-oxime derivatives 2–7. Second, a series of diversified 2-arylindole derivatives (10) were synthesized from an array of substituted 2-iodoanilines (8) and terminal alkynes (9) by applying a one-pot palladium catalyzed Sonogashira-type alkynylation and base-assisted cycloaddition. Subsequent biological evaluations revealed 3-carboxaldehyde oxime and cyano substituted 2-phenylindoles 5 and 7 exhibited the strongest nitrite inhibitory activities (IC(50) = 4.4 ± 0.5 and 4.8 ± 0.4 μM, respectively); as well as NFκB inhibition (IC(50) = 6.9 ± 0.8 and 8.5 ± 2.0 μM, respectively). In addition, the 6′-MeO-naphthalen-2′-yl indole derivative 10at displayed excellent inhibitory activity against NFκB with an IC(50) value of 0.6 ± 0.2 μM.
pH‐Regulated Asymmetric Transfer Hydrogenation of Quinolines in Water (2009)

In buffered water, a broad range of quinoline derivatives underwent asymmetric transfer hydrogenation in air with the rhodium catalyst 1 and sodium formate as the hydrogen source to furnish synthetically important 1,2,3,4-tetrahydroquinolines with excellent enantioselectivities (see scheme; R=H, Me, F, Cl, Br, OMe; R′=alkyl, aryl). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Partial linear fit: A new NMR spectroscopy preprocessing tool for pattern recognition applications (1996)

NMR spectroscopy is increasingly used in combination with multivariate analysis applications. Especially in the analysis of food products and the study of natural processes it has proved its usefulness. The samples used in these evaluations are however, often difficult to control. ‘Positional’ shifts of peaks due to differences in pH and other physico-chemical interactions are quite common. A reduction of the resolution of the spectra is generally sufficient to correct for these effects. This approach is, however, not possible if the fine structure in the data is important in the analysis. A solution to this problem is to use the partial linear fit (PLF) algorithm described here. Using PLF preprocessing the fine structure in the data is utilized to correct for any ‘positional’ variances, which results in a significant improvement in the classification ability and a greater stability of the multivariate data analysis. © 1996 by John Wiley & Sons, Ltd.