gebhart/patrepeval huggingface dataset:
Effect of fuzzy logic-controlled SMES on damping turbine generator shaft torsional oscillations during unsuccessful reclosing (2008)

This paper analyzes the effect of the fuzzy logic-controlled superconducting magnetic energy storage (SMES) on damping turbine-generator shaft torsional oscillations during unsuccessful reclosing of circuit breakers. The control scheme of SMES is based on a PWM voltage source converter (VSC) and a two-quadrant DC-DC chopper using Gate-turn-off (GTO) thyristor. Simulation results of both balanced and unbalanced faults in a single machine connected to an infinite bus system show that the proposed fuzzy logic-controlled SMES is effective in damping shaft torsional oscillations of synchronous generators during unsuccessful reclosing of circuit breakers.
The carboxy-terminal F domain of the human estrogen receptor: role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists. (1995)

Of the steroid hormone receptor family members, the estrogen receptor (ER) is notable in containing a sizable (42-amino acid) C-terminal region, denoted domain F. This F region differs from its adjacent hormone-binding domain, domain E, in that it is not well conserved among different vertebrate ER species, and its role in the biological activity of the ER is not well defined. We report an important role for the F domain of the ER in modulating the magnitude of gene transcription by estrogen and antiestrogen, and in determining the effectiveness of antiestrogens in suppressing estrogen-stimulated gene transcription. Using transient transfections, we have examined, in several cell types, the transcriptional activity of the full-length wild type human ER and ER lacking the carboxy-terminal F domain (delta F ER, containing amino acids 1-554) or ER altered in the F domain by point mutations. In some cells, namely Chinese hamster ovary (CHO) cells and MDA-MB-231 human breast cancer cells expressing wild type ER or delta F ER, estradiol (E2) stimulates equally transcription of several estrogen-responsive promoter-reporter gene constructs [estrogen ca-18119 element, (ERE)2-TATA-CAT, (ERE)2-pS2-CAT, (ERE)2-progesterone receptor(distal)-CAT]; however, the antiestrogens trans-hydroxytamoxifen and ICI 164,384, which stimulate transcription of some of these reporter constructs with the wild type ER, were unable to stimulate transcription with delta F ER. In addition, these antiestrogens were more effective antagonists of E2-stimulated transcription by delta F ER than by wild type ER. By contrast, in HeLa human cervical cancer cells and 3T3 mouse fibroblast cells, the delta F ER exposed to E2 is much less effective than wild type ER in stimulating transcription, and antiestrogens were less potent in suppressing E2-stimulated transcription by the delta F ER. These differences in response of the delta F and wild type ER to estrogen or antiestrogen do not appear to be due to a change in receptor expression level, binding affinity for ligands, or binding to estrogen response element DNA. Our data support the supposition that the conformation of the receptor-ligand complex is different with estrogen vs. antiestrogen and with wild type vs. delta F ER, such that its potential for interaction with protein cofactors or transcription factors is different and is markedly influenced by cell context. Thus, the F domain of the ER has a specific modulatory function that affects the agonist/antagonist effectiveness of antiestrogens and the transcriptional activity of the liganded ER in cells.
Revisiting Square-Root ORAM: Efficient Random Access in Multi-party Computation (2016)

Hiding memory access patterns is required for secure computation, but remains prohibitively expensive for many interesting applications. Prior work has either developed custom algorithms that minimize the need for data-dependant memory access, or proposed the use of Oblivious RAM (ORAM) to provide a general-purpose solution. However, most ORAMs are designed for client-server scenarios, and provide only asymptotic benefits in secure computation. Even the best prior schemes show concrete benefits over naïve linear scan only for array sizes greater than 100. This immediately implies each ORAM access is 100 times slower than a single access at a known location. Even then, prior evaluations ignore the substantial initialization cost of existing schemes. We show how the classical square-root ORAM of Goldreich and Ostrovsky can be modified to overcome these problems, even though it is asymptotically worse than the best known schemes. Specifically, we show a design that has over 100x lower initialization cost, and provides benefits over linear scan for just 8 blocks of data. For all benchmark applications we tried, including Gale-Shapley stable matching and the scrypt key derivation function, our scheme outperforms alternate approaches across a wide range of parameters, often by several orders of magnitude.
MODULATION BY THIOLS OF THE MEROCYANINE 540‐SENSITIZED PHOTOLYSIS OF LEUKEMIA CELLS, RED CELLS, AND <i>Herpes simplex</i> VIRUS TYPE 1 (1991)

This paper reports on the role of endogenous and exogenous thiols in the merocyanine 540 (MC 540)-sensitized photoirradiation of L1210 leukemia cells, human erythrocytes, and human Herpes simplex virus type 1. Several measures taken to decrease the intracellular content of glutathione enhanced the cells' sensitivity to MC 540-sensitized photoirradiation while stimulation of glutathione biosynthesis or supplementation of the extracellular or extraviral thiol content decreased the photosensitivity of cells and viruses. Taken together, these data suggest that endogenous and exogenous thiols can modulate the sensitivity of cells and enveloped viruses to MC 540-sensitized photoirradiation. They also pose new questions as to the mechanism of MC 540-sensitized photolysis.
Ghostman: Augmented Reality Application for Telerehabilitation and Remote Instruction of a Novel Motor Skill (2014)

This paper describes a pilot study using a prototype telerehabilitation system (Ghostman). Ghostman is a visual augmentation system designed to allow a physical therapist and patient to inhabit each other's viewpoint in an augmented real-world environment. This allows the therapist to deliver instruction remotely and observe performance of a motor skill through the patient's point of view. In a pilot study, we investigated the efficacy of Ghostman by using it to teach participants to use chopsticks. Participants were randomized to a single training session, receiving either Ghostman or face-to-face instructions by the same skilled instructor. Learning was assessed by measuring retention of skills at 24-hour and 7-day post instruction. As hypothesised, there were no differences in reduction of error or time to completion between participants using Ghostman compared to those receiving face-to-face instruction. These initial results in a healthy population are promising and demonstrate the potential application of this technology to patients requiring learning or relearning of motor skills as may be required following a stroke or brain injury.
<title>Actively mode-locked Er-doped fiber laser incorporating Bragg gratings written in polarization-maintaining fiber</title> (2001)

Bragg gratings were written in H<SUB>2</SUB>-loaded polarization- maintaining fiber (PM-FBGs) and inserted in an actively mode-locked Er-doped fiber laser. The use of PM-FBG in sigma laser cavity allows to effectively build all polarization- maintaining fiber laser. Long term stabilization of the laser was ensured by a feedback loop that controlled the cavity length. Peak wavelengths, reflection bandwidths and reflectivity values of the grating were equal to 1545.5 nm and 1540.5 nm, 1.6-nm and 0.8-nm, of 99% and 90%, respectively. At a 3-GHz repetition rate, pulses of 9.4-ps and 27.9-ps duration were generated with first and second gratings, respectively. By inserting additional long piece of dispersion-shifted fiber in the cavity, nonlinear pulse shortening was observed due to formation of average soliton inside the cavity. In this case, pulses of 7.8-ps and 22.7- ps duration were generated with first and second gratings, respectively. With the first grating, generated pulses were close to transform limit for hyperbolic secant pulse shape. Longer pulse duration obtained with second grating is attributed to narrower bandwidth and residual chirp of the grating.
Design of technology-based self-service for ICU patients' families (2009)

Caring in intensive care unit (ICU) is taken seriously in the whole medical process. Past research usually focused on satisfying ICU patients or medical personnel's needs, requirements of patients' families were often been ignored. To establish “CarePlus” - a comprehensive technology-based self-service (TBSS) for ICU patients' families - is the objective of this research. Based on the finding through literature review and investigation on needs of patients' families, design of services were developed, which include Hospital Related Information, ICU Related Information, ICU Patient's Family Related Information, Living Information, Patient Nursing Information, Medical Information, Consultation Hotlines, Religious and Spiritual Support. ICU of NCKU Hospital was employed for evaluation, where target subject tested the dedicated TBSS and their feedbacks were analyzed quantitatively. The result indicates that patients' families show high affirmation toward CarePlus, and their need gaps will be reduced after trying this service.
Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis (2008)

The neuronal ceroid lipofuscinoses comprise a group of inherited severe neurodegenerative lysosomal disorders characterized by lysosomal dysfunction and massive accumulation of fluorescent lipopigments and aggregated proteins. To examine the role of lipids in neurodegenerative processes of these diseases, we analysed phospho- and glycolipids in the brains of ctsd-/- and nclf mice, disease models of cathepsin D and CLN6 deficiency, respectively. Both ctsd-/- and nclf mice exhibited increased levels of GM2 and GM3 gangliosides. Immunohistochemically GM2 and GM3 staining was found preferentially in neurons and glial cells, respectively, of ctsd-/- mice. Of particular note, a 20-fold elevation of the unusual lysophospholipid bis(monoacylglycero)phosphate was specifically detected in the brain of ctsd-/- mice accompanied with sporadic accumulation of unesterified cholesterol in distinct cells. The impaired processing of the sphingolipid activator protein precursor, an in vitro cathepsin D substrate, in the brain of ctsd-/- mice may provide the mechanistic link to the storage of lipids. These studies show for the first time that cathepsin D regulates the lysosomal phospho- and glycosphingolipid metabolism suggesting that defects in the composition, trafficking and/or recycling of membrane components along the late endocytic pathway may be critical for the pathogenesis of early onset neuronal ceroid lipofuscinoses.
Tumour targeting by microtubule-depolymerising vascular disrupting agents (2007)

Low molecular weight vascular disrupting agents of the microtubule depolymerizing family cause marked and selective disruption of the established tumour blood vessel network, resulting in tumour cell necrosis. The combretastatins are members of this family and these, together with several other related compounds, have undergone extensive preclinical testing and are now in clinical trials for cancer. Potentially, vascular disrupting agents can also interfere with angiogenesis and constitute a very promising group of novel cancer drugs. In vitro analysis of their signalling activities points to the endothelial cytoskeleton as being their major target and a key player in the events that culminate in vascular collapse. As more of these agents progress into the clinical setting, more research in this area is warranted in order to decipher exact mechanisms responsible for vascular disruption and to understand the reasons for drug selectivity for the tumour vasculature. This information is essential in order to identify new targets within the tumour vasculature and to improve present therapies.
Learning object intrinsic structure for robust visual tracking (2003)

In this paper, a novel method to learn the intrinsic object structure for robust visual tracking is proposed. The basic assumption is that the parameterized object state lies on a low dimensional manifold and can be learned from training data. Based on this assumption, firstly we derived the dimensionality reduction and density estimation algorithm for unsupervised learning of object intrinsic representation, the obtained non-rigid part of object state reduces even to 2 dimensions. Secondly the dynamical model is derived and trained based on this intrinsic representation. Thirdly the learned intrinsic object structure is integrated into a particle-filter style tracker. We will show that this intrinsic object representation has some interesting properties and based on which the newly derived dynamical model makes particle-filter style tracker more robust and reliable. Experiments show that the learned tracker performs much better than existing trackers on the tracking of complex non-rigid motions such as fish twisting with self-occlusion and large inter-frame lip motion. The proposed method also has the potential to solve other type of tracking problems.
Luciferase Imaging of a Neurotropic Viral Infection in Intact Animals (2003)

The identification of viral determinants of virulence and host determinants of susceptibility to virus-induced disease is essential for understanding the pathogenesis of infection. Obtaining this information requires infecting large numbers of animals to assay amounts of virus in a variety of organs and to observe the onset and progression of disease. As an alternative approach, we have used a murine model of viral encephalitis and an in vivo imaging system that can detect light generated by luciferase to monitor over time the extent and location of virus replication in intact, living mice. Sindbis virus causes encephalomyelitis in mice, and the outcome of infection is determined both by the strain of virus used for infection and by the strain of mouse infected. The mode of entry into the nervous system is not known. Virulent and avirulent strains of Sindbis virus were engineered to express firefly luciferase, and the Xenogen IVIS system was used to monitor the location and extent of virus replication in susceptible and resistant mice. The amount of light generated directly reflected the amount of infectious virus in the brain. This system could distinguish virulent and avirulent strains of virus and susceptible and resistant strains of mice and suggested that virus entry into the nervous system could occur by retrograde axonal transport either from neurons innervating the initial site of replication or from the olfactory epithelium after viremic spread.
[The temperature regimens for transurethral thermotherapy in treating benign prostatic hyperplasia]. (1997)

Transurethral microwave thermotherapy (Prostalund unit made by Lund Instruments) was given to 49 patients with benign prostatic hyperplasia. The prostate was heated transurethrally for 60 min. Only one procedure was performed. Temperature regimens were different: prostatic tissue was heated to 50 degrees C, 55 degrees C and 60 degrees C (14, 17 and 18 patients, respectively). The response assessed 6 months after the treatment was the best in the group on the highest temperature regimen.
Fabrication of biological arrays by unconventional lithographic methods (2009)

Biological arrays with dimensions less than 100 nm are emerging as a new tool for biological research in the fields of genomics, proteomics, cell analysis, and tissue engineering. In this review, unconventional lithographic methods for the fabrication of biological arrays are summarized and compared in terms of spot size, density, resolution and ease in fabrication. The methods are classified into three categories: a) direct transfer of biological species on the substrate, b) selective deposition on the patterned surface using an adhesion-controlled template material, and c) stencil or membrane-based deposition on specific regions of a substrate. This review would be useful to related researchers in bioscience and bioengineering.
Registry in a tube: multiplexed pools of retrievable parts for genetic design space exploration (2016)

Genetic designs can consist of dozens of genes and hundreds of genetic parts. After evaluating a design, it is desirable to implement changes without the cost and burden of starting the construction process from scratch. Here, we report a two-step process where a large design space is divided into deep pools of composite parts, from which individuals are retrieved and assembled to build a final construct. The pools are built via multiplexed assembly and sequenced using next-generation sequencing. Each pool consists of ∼20 Mb of up to 5000 unique and sequence-verified composite parts that are barcoded for retrieval by PCR. This approach is applied to a 16-gene nitrogen fixation pathway, which is broken into pools containing a total of 55 848 composite parts (71.0 Mb). The pools encompass an enormous design space (1043 possible 23 kb constructs), from which an algorithm-guided 192-member 4.5 Mb library is built. Next, all 1030 possible genetic circuits based on 10 repressors (NOR/NOT gates) are encoded in pools where each repressor is fused to all permutations of input promoters. These demonstrate that multiplexing can be applied to encompass entire design spaces from which individuals can be accessed and evaluated.
Immunogenicity of a Live Recombinant<i>Salmonella</i><i>enterica</i>Serovar Typhimurium Vaccine Expressing<i>pspA</i>in Neonates and Infant Mice Born from Naive and Immunized Mothers (2010)

We are developing a Salmonella vectored vaccine to prevent infant pneumonia and other diseases caused by Streptococcus pneumoniae. One prerequisite for achieving this goal is to construct and evaluate new recombinant attenuated Salmonella vaccine (RASV) strains suitable for use in neonates and infants. Salmonella enterica serovar Typhimurium strain chi9558(pYA4088) specifies delivery of the pneumococcal protective antigen PspA and can protect adult mice from challenge with S. pneumoniae. This strain is completely safe for oral delivery to day-old and infant mice. Here we assess the colonizing ability, immunogenicity, and protective efficacy of chi9558(pYA4088) in neonatal mice. Colonization was assessed in mice 0, 2, 4, or 7 days of age after oral inoculation. In the presence of maternal antibodies, the colonization of lymphoid tissues was delayed, but the immune responses were enhanced in mice born to immunized mothers. Both oral and intranasal routes were used to assess immunogenicity. All orally or intranasally immunized neonatal and infant mice born to either immunized or naïve mothers developed PspA-specific mucosal and systemic immune responses. Mice born to immunized mothers produced higher titers of PspA-specific antibodies in the blood and mucosa and greater numbers of PspA-specific interleukin-4 (IL-4)-secreting cells than mice born to naïve mothers. More importantly, mice born to immune mothers showed a significant increase in protection against S. pneumoniae challenge. These results suggest that strain chi9558(pYA4088) can circumvent some of the limitations of the immature immune system in neonatal and infant mice, generating enhanced protective immune responses in the presence of maternal antibodies.
Array lessons from the heart: focus on the genome and transcriptome of cardiomyopathies (2005)

Our understanding of the cardiovascular system has evolved through the years by extensive studies emphasizing the identification of the molecular and physiological mechanisms involved in its normal function and disease pathogenesis. Major discoveries have been made along the way. However, the majority of this work has focused on specific genes or pathways rather than integrative approaches. In cardiomyopathies alone, over 30 different loci have shown mutations with varying inheritance patterns, yet mostly coding for structural proteins. The emergence of microarrays in the early 1990s paved the way to a new era of cardiovascular research. Microarrays dramatically accelerated the rhythm of discoveries by giving us the ability to simultaneously study thousands of genes in a single experiment. In the field of cardiovascular research, microarrays are having a significant contribution, with the majority of work focusing on end-stage cardiomyopathies that lead to heart failure. Novel molecular mechanisms have been identified, known pathways are seen under new light, disease subgroups begin to emerge, and the effects of various drugs are molecularly dissected. This cross-study data comparison concludes that consistent energy metabolism gene expression changes occur across dilated, hypertrophic, and ischemic cardiomyopathies, while Ca2+ homeostasis changes are prominent in the first two cardiomyopathies, and structural gene expression changes accompany mostly the dilated form. Gene expression changes are further correlated to disease genetics. The future of microarrays in the cardiomyopathy field is discussed with an emphasis on optimum experimental design and on applications in diagnosis, prognosis, and drug discovery.
An Analysis of Random<i>d</i>-Dimensional Quad Trees (1990)

It is shown that the depth of the last node inserted in a random quad tree constructed from independent uniform $[0,1]^d $ random vectors is in probability asymptotic to $({2 / d}) \log n$, where log denotes the natural logarithm. In addition, for $d = 2$, exact values are obtained for all the moments of the depth of the last node.
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCES & RESEARCH TECHNOLOGY EVALUATING PERFORMANCE AND SECURITY OF WPA USING SHA1 (2015)

Wirelesses Local Area Networks (WLANs) have become more common and are widely used in many places like university campuses etc. With Growing popularity, the security of wireless network has become very important issue .Wi-Fi device needs the security so as to protect it from unauthorized access and data theft. WPA protocol are used for security of wireless network .In this paper evaluation of MAC and SHA-1 is performed by calculating throughput and the results shows improvement of WPA using SHA1.
The Effect of Micronized Fenofibrate on Lipid Profiles of Patients Converted from Gemfibrozil (2002)

Although numerous studies have established the efficacy of micronized fenofibrate (MF) and gemfibrozil in improving lipid profiles, there are limited comparative data on the lipid-lowering effects of these two agents. The objective of this study was to evaluate the mean changes in lipid values of hypertriglyceridemic patients crossed over from gemfibrozil to MF. The Medical charts of 21 patients were analyzed retrospectively. Patients were maintained on gemfibrozil 600 mg twice daily for a minimum of 3 months. The patient's last fasting lipid profile on gemfibrozil was compared to the first lipid profile after crossover to MF 200 to 201 mg/day. Patients were excluded if there were alterations in other lipid-lowering therapy during the cross-over or documented non-adherence. The lipid profiles after the crossover showed a significant reduction in triglycerides (56%; P < 0.05) and TC/HDL ratio (38%; P < 0.05) and a significant increase in HDL (22%; P < 0.05). There were nonsignificant changes in other lipid values: TC (-22%; P = 0.058), LDL (+5%; P = 0.866) and LDL/HDL ratio (+6; P = 1.0). The results show that MF had additional favorable effects on triglycerides, HDL, and TC/HDL ratio compared with gemfibrozil. A larger, randomized trial to confirm these effects is warranted.