gebhart/patrepeval huggingface dataset:
Optimizing Video Object Detection via a Scale-Time Lattice (2018)

High-performance object detection relies on expensive convolutional networks to compute features, often leading to significant challenges in applications, e.g. those that require detecting objects from video streams in real time. The key to this problem is to trade accuracy for efficiency in an effective way, i.e. reducing the computing cost while maintaining competitive performance. To seek a good balance, previous efforts usually focus on optimizing the model architectures. This paper explores an alternative approach, that is, to reallocate the computation over a scale-time space. The basic idea is to perform expensive detection sparsely and propagate the results across both scales and time with substantially cheaper networks, by exploiting the strong correlations among them. Specifically, we present a unified framework that integrates detection, temporal propagation, and across-scale refinement on a Scale-Time Lattice. On this framework, one can explore various strategies to balance performance and cost. Taking advantage of this flexibility, we further develop an adaptive scheme with the detector invoked on demand and thus obtain improved tradeoff. On ImageNet VID dataset, the proposed method can achieve a competitive mAP 79.6% at 20 fps, or 79.0% at 62 fps as a performance/speed tradeoff.
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure (2002)

The murine dishevelled 2 (Dvl2) gene is an ortholog of the Drosophila segment polarity gene Dishevelled, a member of the highly conserved Wingless/Wnt developmental pathway. Dvl2-deficient mice were produced to determine the role of Dvl2 in mammalian development. Mice containing null mutations in Dvl2 present with 50% lethality in both inbred 129S6 and in a hybrid 129S6-NIH Black Swiss background because of severe cardiovascular outflow tract defects, including double outlet right ventricle, transposition of the great arteries and persistent truncus arteriosis. The majority of the surviving Dvl2(-/-) mice were female, suggesting that penetrance was influenced by sex. Expression of Pitx2 and plexin A2 was attenuated in Dvl2 null mutants, suggesting a defect in cardiac neural crest development during outflow tract formation. In addition, approximately 90% of Dvl2(-/-) mice have vertebral and rib malformations that affect the proximal as well as the distal parts of the ribs. These skeletal abnormalities were more pronounced in mice deficient for both Dvl1 and Dvl2. Somite differentiation markers used to analyze Dvl2(-/-) and Dvl1(-/-);Dvl2(-/-) mutant embryos revealed mildly aberrant expression of Uncx4.1, delta 1 and myogenin, suggesting defects in somite segmentation. Finally, 2-3% of Dvl2(-/-) embryos displayed thoracic spina bifida, while virtually all Dvl1/2 double mutant embryos displayed craniorachishisis, a completely open neural tube from the midbrain to the tail. Thus, Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure, and there is functional redundancy between Dvl1 and Dvl2 in some phenotypes.
Lotus Notes? 4.5 For Dummies? (1997)

From the Publisher:
Your company just got Lotus Notes, and you don't know where to start? Or maybe new features in Notes 4.5 -- including the Domino Server -- have left you in the dark? Never fear; Lotus Notes 4.5 For Dummies takes you by the hand and guides you quickly and painlessly through groupware and network basics. Whether you're working on Notes at the office or taking your show on the road, this book is your ideal companion. Finally, a friendly, accessible reference to make you feel like a techno-genius, even if you're not! 
Inside, find helpful advice on how to 
Increase communication and save time with electronic mail Discover tips for making a smooth transition from cc:Mail to Lotus Notes Get lifesaving advice for taking Notes on the road Tap into the Internet with the cool Notes Web Navigator Dive into Notes databases and applications with ease Share spreadsheets and documents with your coworkers for maximum efficiency Use the scheduling features and never miss another meeting
Geochemistry of a Rapakivi Granite Suite in a Proterozoic Rift Trough in Beijing and Its Vicinity (1991)

Controlled by E-W-trending faults, a Proterozoic (1.4-1.8 Ga old) rapakivi granite suite was intruded inBeijing and the area to its east (within Hebei Province), forming three parallel belts of igneous rocks. Theisotopic, trace element and rare earth element geochemical data of a bimodal rock association made up ofanorthosite, gabbro and alkali basalt and olivine-bearing quartz-syenite, rapakivi granite and trachyte as wellas potassic A-type granites and anorogenic granites—— all suggest that there exists an incipient rift in thestudy area. Fractional crystallization of a mixed magma formed by the magma derived from the upper mantleand the magma derived by small degrees of fusion of the lower crust produced anorthosite cumulates. Thewater-deficient granitic magma was differentiated into a subalkaline series. When the fractional crystallizationwas incomplete, rhythmic eruptions took place.
Secondary Structure Mapping of DnaK-Bound Protein Fragments:  Chain Helicity and Local Helix Unwinding at the Binding Site (2006)

Little is known about polypeptide conformation and folding in the presence of molecular chaperones participating in protein biosynthesis. In vitro studies on chaperone-substrate complexes have been mostly carried out with small peptide ligands. However, the technical challenges associated with either competing aggregation or spectroscopically unfavorable size and exchange rates have typically prevented analysis of larger substrates. Here, we report the high-resolution secondary structure of relatively large N-terminal protein fragments bound to the substrate-binding domain of the cotranslationally active chaperone DnaK. The all-alpha-helical protein apomyoglobin (apoMb), bearing the ubiquitous globin fold, has been chosen as a model substrate. On the basis of NMR secondary chemical shift analysis, we identify, for the first time, weak helical content (similar to that found in the chemically unfolded full-length protein) for the assigned residues of the chaperone-bound chain away from the chaperone binding sites. In contrast, we found that the residues corresponding to the strongest specific binding site for DnaK, examined via a short 13-mer apoMb peptide fragment matching the binding site sequence, display highly reduced helical content in their chaperone-bound form. Given that the free state of the peptide is weakly helical in isolation, we conclude that the substrate residues corresponding to the chaperone binding site undergo helix unwinding upon chaperone binding.
Primary Care Physician Shortages Could Be Eliminated Through Use Of Teams, Nonphysicians, And Electronic Communication (2013)

Most existing estimates of the shortage of primary care physicians are based on simple ratios, such as one physician for every 2,500 patients. These estimates do not consider the impact of such ratios on patients' ability to get timely access to care. They also do not quantify the impact of changing patient demographics on the demand side and alternative methods of delivering care on the supply side. We used simulation methods to provide estimates of the number of primary care physicians needed, based on a comprehensive analysis considering access, demographics, and changing practice patterns. We show that the implementation of some increasingly popular operational changes in the ways clinicians deliver care-including the use of teams or "pods," better information technology and sharing of data, and the use of nonphysicians-have the potential to offset completely the increase in demand for physician services while improving access to care, thereby averting a primary care physician shortage.
Viral vectors expressing immunoregulatory cytokines to treat inflammatory bowel disease (1998)

Inflammatory bowel disease (IBD) is characterised by altered immunoregulation and augmented synthesis of nitric oxide. The purpose of this study was to determine the effects of exogenous IL-4, introduced by a recombinant human type 5 adenovirus (Ad5) vector, on the tissue injury associated with an experimental model of colonic immune activation and inflammation. Colitis was induced in rats by the intrarectal administration of trinitrobenzene sulfonic acid (TNB) dissolved in 50% ethanol, and control rats received saline via the same route. 1 h later, all rats were randomized into two groups. The first group was injected intraperitoneally (i.p.) with 3.0 x 10(6) plaque forming units (PFUs) of Ad5 transfected with murine interleukin-4 (Ad5IL-4) and the second group was injected i.p. with the same amount of Ad5 expressing the Escherichia coli Lac Z gene (Ad5LacZ). One-half of the colitic and controls rats were injected again with 3.0 x 10(6) PFUs of Ad5IL-4 or Ad5LacZ on day 3 of the 6-d study. When introduced once or twice via the peritoneal route into control rats Ad5LacZ was localised to the serosal lining of the peritoneal cavity, the diaphragm and the liver on day 6. One or two injections of Ad5IL-4 into rats also produced measurable levels of circulating IL-4. TNB-colitis in both Ad5LacZ-treated groups was associated with pronounced elevations in serum IFN-gamma, and mucosal ulceration of the distal colon. Myeloperoxidase and inducible nitric oxide synthase II (NOS II) synthetic activity were also increased by 30- and fivefold, respectively, above control levels in the distal colon. However, two injections of AD5IL-4 into colitic rats caused the overexpression of IL-4, and significantly inhibited tissue damage, serum and colon IFN-gamma levels and myeloperoxidase activity in the distal colon. In addition, NOS II gene expression and NOS II nitric oxide synthesis was significantly inhibited. No therapeutic effect was observed in rats injected once with AD5IL-4. Thus, IL-4, introduced by Ad5, is therapeutic during acute inflammation in the rat colon. The therapeutic effect of IL-4 was associated with an inhibition of inducible nitric oxide expression and a reduction in nitric oxide synthesis.
A Vehicle Collision Warning System Employing Vehicle-To-Infrastructure Communications (2008)

Road safety has become an important issue and gained much attention for many years. To avoid vehicle collisions on the roads, researchers have proposed various collision warning systems (CWS) using different technologies. Compared with CWS using other technologies, a radio-based CWS is more capable of avoiding collisions in off-sight scenarios (such as the four corners of an intersection). Most existing radio-based CWSs operate using vehicle-to-vehicle communications. However, in such CWSs, high mobility of moving vehicles easily results in message collisions and link breakage, impairing the reliability of these CWSs. An alternative is employing vehicle-to-infrastructure communication to build CWSs. In this paper, we propose a radio-based CWS employing vehicle-to-infrastructure communications. Our simulation results show that the proposed CWS can effectively reduce the number of vehicle collisions without degrading the traffic throughput of a road network.
IL-4 increases type 2, but not type 1, cytokine production in CD8+ T cells from mild atopic asthmatics (2005)

These data suggest that during a respiratory virus infection activated CD8+ T cells from asthmatic subjects may produce excess type 2 cytokines and may contribute to asthma exacerbation by augmenting allergic inflammation.
Eine neuartige Fragmentierung bicyclischer Enoläther Verfahren zur Darstellung macrocyclischer Lactone (1971)

Abstract Vicinal α‐hydroperoxy‐tetrahydropyranyl ethers annelated to cyclododecane are smoothly converted by homolytic fission in about 75% yield to a mixture of the macrocyclic lactones 3 , 4 , and 5. Based on this observation, an economically feasible synthesis of Exaltolide 1 (>65% yield) has been developed. The mechanism of this new β‐fragmentation reaction is discussed.
A Review of Astrocytoma in Childhood (1989)

Between 1954 and 1984, 282 children with astrocytoma were included in the Manchester Children's Tumour Registry (MCTR), giving an overall incidence of 9.3 per million person-years. There were 110 children with adult astrocytoma and 172 children with juvenile astrocytoma. The five-year survival for adult astrocytoma was 15% and 75% for juvenile astrocytoma. There were no significant improvements in survival with time. There were 21 children with neurofibromatosis (NF) and 4 children had tuberous sclerosis. Some children had other recognized syndromes and others had major or minor abnormalities. Nine children had second tumors, mainly associated with NF, and seven siblings had malignant tumors. A number of mothers of these children were found to have breast cancer. Some of these families may represent examples of the Li-Fraumeni cancer family syndrome. We conclude that astrocytomas is an important problem in childhood and that a proportion of cases may have a genetic origin.
Electro-optical effect in hydrogenated amorphous silicon-based waveguide-integrated p-i-p and p-i-n configurations (2013)

A p-i-p configuration of an electro-optical modulator based on hydrogenated amorphous silicon (a-Si:H) is characterized and compared with an a-Si:H based p-i-n modulator. In particular, we estimate the performances in terms of optical losses, voltage-length product, and bandwidth at λ=1550 nm for waveguide-integrated p-i-p versus p-i-n configurations. Both devices are fabricated on a silicon substrate by plasma enhanced chemical vapor deposition at low temperature ensuring the back-end integration with a CMOS microchip. We demonstrate a factor of merit for the p-i-p waveguide integrated Fabry-Perot resonator of Vπ×Lπ=19 V×cm allowing the design of shorter devices with respect to p-i-n structure.
Long-term Subcutaneous Recombinant Interleukin-2 as Maintenance Therapy: Biological Effects and Clinical Implications (1995)

Several trials have evaluated the therapeutic efficacy of rIL-2 combined with more traditional treatments such as chemotherapy and radiotherapy, but the use of IL-2 as adjuvant therapy for minimal residual disease or to maintain clinical response obtained with other standard treatments has yet to be investigated. The aim of the present trial was to study the biological effects of maintenance long-term treatment (6 months) with subcutaneous low-dose IL-2 in 16 patients with different neoplasms previously treated with chemo-immuno therapeutic regimens or with surgery (7 metastatic renal cancers, 5 locally advanced renal cancers previously subjected to radical nephrectomy, 2 metastatic breast cancers, 1 small cell lung cancer, and 1 metastatic melanoma). Clinical tolerability, feasibility and therapeutic implications are also discussed. The IL-2 schedule was as follows: 4.5 million IU/day, 3 times weekly for 6 months. A total of 14 patients completed therapy without requiring dose modifications and are free of progression after a median duration of 8+ months (range: 7+ to 34+) while two patients progressed during therapy (one inflammatory breast cancer and one renal cancer). Important and persistent hemato-immunostimulating effects in both soluble (IL-2, sIL-2R, IL-6) and cellular (lymphocyte subsets, monocytes, eosinophils) parameters were noted during the entire treatment. The IL-2 related toxicity was quite low. Moreover, this long-term IL-2 therapy could control neoplastic growth and thus prolong clinical response obtained with standard treatments. Prospective randomized studies regarding the clinical efficacy have been initiated.
Solitary and shock waves in discrete double power-law materials (2007)

A novel strongly nonlinear laminar metamaterial supporting new types of solitary and shock waves with impact energy mitigating capabilities is presented. It consists of steel plates with intermittent polymer toroidal rings acting as strongly nonlinear springs with large allowable strain. Their force-displacement relationship is described by the addition of two power-law relationships resulting in a solitary wave speed and width depending on the amplitude. This double nonlinearity allows splitting of an initial impulse into two separate strongly nonlinear solitary wave trains. Solitary and shock waves are observed experimentally and analyzed numerically in an assembly with Teflon o-rings.
Cementoblasts Maintain Expression of Osteocalcin in the Presence of Mineral Trioxide Aggregate (2003)

This study investigated the effects of mineral trioxide aggregate on cementoblast growth and osteocalcin production in tissue culture. For cellular morphology studies, cementoblasts on mineral trioxide aggregate, IRM, and amalgam were incubated for 48 h then fixed for scanning electron microscopic analysis. For gene expression on mineral trioxide aggregate and IRM, reverse transcriptase polymerase chain reaction was performed using primer sets for glyceraldehyde-3-phosphate dehydrogenase, type I collagen, alkaline phosphatase, osteocalcin, and bone sialoprotein after 3 and 5 days. In vitro matrix protein expression was evaluated by confocal microscopy for the presence of osteocalcin on MTA after 7 and 12 days. Images were compared with controls to assess qualitative differences. Results suggest that mineral trioxide aggregate permits cementoblast attachment and growth and the production of mineralized matrix gene and protein expression. Our data indicates that mineral trioxide aggregate can be considered cementoconductive.
Factores asociados al abandono del programa control prenatal en embarazadas captadas en primer y segundo trimestre de gestación. Silais Central. Región III, 2do. semestre 1992 (1993)

El presente estudio es de tipo descriptivo de corte transversal, con el objetivo de identificar los factores asociados al abandono de las embarazadas captadas en el control prenatal en su primer y segundo trimestre de gestacion durante los meses de Junio a Diciembre de 1992, en los puestos y Centros de Salud de SILAIS Central, Managua. Para determinar estos factores se hizo necesario conocer las caracteristicas generales de la Madre, percepcion y las condiciones higienicas sanitarias en que vive; obteniendose que los porcentajes de factores asociados al abandono en el estudio son: traslados a Hospitales, cambio domiciliar, aborto, cambio de la atencion a clinicas privadas, seguidas de crisis familiar, insatisfaccion con la atencion y crisis laboral. En segundo lugar encontramos que parte de los problemas encontrados en la atencion estaba relacionada con las Unidades de Salud las que fueron tipificadas segun la estructura y funcionamiento del programa de control prenatal. Para eso tomaron el 100 porciento del universo que lo constituian 132 abandonos. Se utilizo como metodologia para recoger la informacion la entrevista domiciliar y la observacion directa a las Unidades de Salud, ademas de la revision de registros de atencion diaria, encontrando que las mismas fueron catalogadas como malas condiciones de atencion, producto de falta de equipo, horario de atencion, etc. La conclusion principal en este trabajo se asocio a la insuficiente organizacion y poca vinculacion de las Unidades de Salud, con la Comunidad, ademas de una elevada rotacion del personal designado a las mismas. Dentro de las recomendaciones plantean realizar acciones de busqueda en el terreno, promover la educacion permanente tanto al personal de las unidades de salud como a las Madres, fortalecer acciones de monitoreo y evaluacion periodica por parte de los SILAIS y las Unidades de Salud, mejorar la organizacion de los servicios y el Sistema de Informacion de las Unidades de Salud.
Wound-factor-induced and cell cycle phase-dependent expression of 9E3/CEF4, the avian gro gene. (1991)

The gro genes encode for secreted proteins with sequence homologies to inflammatory mediators. Little is known about the function of these proteins or their regulation. The chicken gro (9E3/CEF4) is expressed abundantly in the cells of proliferating cultures but at very low levels in confluent cultures. In vivo, this gene is expressed in connective tissue and overexpressed at sites of injury, especially in areas of neovascularization. Here we provide a bridge between these observations by examining in culture the effect on 9E3 expression and DNA synthesis induced by cell damage and by addition of factors known to be released on wounding. We mimicked wounding by scraping swaths across confluent cultures of embryonic fibroblasts and determined the time dependence of expression of 9E3 mRNA and incorporation of 3H-thymidine. We find that 9E3 is (1) transiently expressed after "wounding" or serum-stimulation; (2) expressed in a cell cycle phase-dependent manner; it is triggered during the G0-G1 transition or early in G1 and subsides during S-phase; and (3) stimulated to high levels by a-fibroblast growth factor (aFGF), bFGF, transforming growth factor alpha (TGF alpha), and TGF beta, to intermediate levels by platelet-derived growth factor and not stimulated by epidermal growth factor. We also find that cells that are constantly cycling do not express 9E3, indicating that they skip either the portion of the cell cycle where 9E3 is induced or that they constitutively express a repressor of transcription or an RNA-degrading enzyme. Taken together, these observations suggest that the product of this gene could play more than one role in vivo. For example, in normal tissues the 9E3 protein could be involved in the exit of cells from the resting stage, whereas during wound healing the secreted protein or its cleavage products also could play a role in angiogenesis.
Effect of diaspirin cross-linked hemoglobin and norepinephrine on systemic hemodynamics and regional circulation in rats. (1994)

Diaspirin cross-linked hemoglobin (DCLHb) (400 mg/kg, i.v.) produced a pressor effect that was equal to that produced by norepinephrine (NE) (25 micrograms/kg/min i.v. infusion). Total peripheral resistance was increased by DCLHb and more significantly by NE. Heart rate was not affected by DCLHb but was significantly increased by NE. The cardiac output and stroke volume were insignificantly increased by DCLHb but were significantly decreased by NE. DCLHb and NE produced a significant increase in blood flow to the heart. The vascular resistance in the heart was not affected by DCLHb but was decreased by NE. DCLHb did not affect the renal and brain circulation, but NE in kidneys decreased the blood flow and increased the vascular resistance, whereas in the brain it increased the blood flow and decreased the vascular resistance. DCLHb increased the blood flow to the stomach and small intestine. The vascular resistance was not affected by DCLHb in the gastrointestinal tract. NE did not affect the blood circulation in the gastrointestinal tract. Blood flow to the spleen was increased by DCLHb, and there was no change in the vascular resistance. NE insignificantly decreased the blood flow to the spleen and significantly increased the vascular resistance. The blood circulation to the mesentery and pancreas was not affected by DCLHb, whereas NE increased the blood flow without affecting the vascular resistance. DCLHb produced a significant increase in the blood flow to the skin without affecting the vascular resistance, whereas NE did not affect the blood flow but increased the vascular resistance. DCLHb did not affect the blood flow to the musculo-skeletal system but increased the vascular resistance, whereas NE decreased the blood flow and increased the vascular resistance. In summary, although the pressor effect of DCLHb and NE at the doses studied is equal, DCLHb did not decrease the blood flow to any organ, whereas NE produced significant decreases in blood flow to several organs. It is concluded that the blood flow to most of the organs is either increased or not affected by DCLHb.
Synthesis of 2-deoxy-2-fluoro-<scp>D</scp>-glucose (1969)

J. Pacák, Z. Točík and M. Černý, J. Chem. Soc. D, 1969, 77 DOI: 10.1039/C29690000077