gebhart/patrepeval huggingface dataset:
Microstrip Lines for Microwave Integrated Circuits (1969)

Microstrips, transmission lines of metallic layers deposited on a dielectric substrate, are very useful for the microwave and millimeter wave hybrid integrated circuits required for solid-state radio systems because of their simplicity and planar structure. To design hybrid integrated circuits with microstrips requires computation or measurement of the impedance, the attenuation, the guide wavelength, and the unloaded Q of the line. These parameters can be obtained from the effective dielectric constant and the characteristic impedance of the corresponding air line. This paper gives the exact design data for all line parameters for the most important cases. We report the impedance and attenuation measurements performed on microstrips. Satisfactory agreement is obtained with theoretical results based on conformal mapping with logarithmic derivatives of theta functions and expressions involving the partial derivatives of the impedance with respect to independent line parameters.
Reaction of thin Ni films with Ge: Phase formation and texture (2006)

The solid-state reaction between a 30-nm-thick Ni film and Ge substrates was investigated using in situ x-ray diffraction, diffuse light scattering, and four-point probe electrical measurements. Our results reveal that Ni5Ge3 and NiGe appear consecutively on Ge(111) while they grow simultaneously on amorphous Ge(α-Ge) and Ge(001). Furthermore, phase formation temperatures depend strongly on the nature of the substrate being the lowest on α-Ge and the highest on Ge(111). X-ray pole figure measurements of the NiGe phase obtained from the reaction with an amorphous substrate indicate a completely random texture while several epitaxial and axiotaxial texture components are observed on both Ge(001) and Ge(111). The texturing for the NiGe film on Ge(111), which showed a sequential phase formation, is an order of magnitude more pronounced than for the film on Ge(001) which showed a simultaneous growth.
Folate deficiency and oral contraceptives (1970)

Orally administered contraceptive agents have become an everyday medication for many women in the United States as well as many other countries. A number of untoward effects<sup>1,2</sup>along with an ever increasing number of minor clinical or laboratory changes have been reported in women using orally administered contraceptives.<sup>2-4</sup>Recently folate deficiency and anemia have been associated with the use of orally administered contraceptives.<sup>5,6</sup>This report concerns seven cases of folate deficiency and anemia apparently due to orally administered contraceptives and studies on the effect of this type of medication on folate absorption. <h3>Clinical Observations</h3> Seven women (21 to 39 years of age) with folate deficiency and anemia were treated at the University of Florida or the Clinical Research Center between September 1968 and April 1969. These patients were taking no medication other than orally administered contraceptives and all had been taking them regularly for at least 1
Induction of Ectopic Eyes by Targeted Expression of the <i>eyeless</i> Gene in <i>Drosophila</i> (1995)

The Drosophila gene eyeless (ey) encodes a transcription factor with both a paired domain and a homeodomain. It is homologous to the mouse Small eye (Pax-6) gene and to the Aniridia gene in humans. These genes share extensive sequence identity, the position of three intron splice sites is conserved, and these genes are expressed similarly in the developing nervous system and in the eye during morphogenesis. Loss-of-function mutations in both the insect and in the mammalian genes have been shown to lead to a reduction or absence of eye structures, which suggests that ey functions in eye morphogenesis. By targeted expression of the ey complementary DNA in various imaginal disc primordia of Drosophila, ectopic eye structures were induced on the wings, the legs, and on the antennae. The ectopic eyes appeared morphologically normal and consisted of groups of fully differentiated ommatidia with a complete set of photoreceptor cells. These results support the proposition that ey is the master control gene for eye morphogenesis. Because homologous genes are present in vertebrates, ascidians, insects, cephalopods, and nemerteans, ey may function as a master control gene throughout the metazoa.
Survival of patients with limited-stage small cell lung cancer treated with individualized chemotherapy selected by in vitro drug sensitivity testing. (1997)

Our purpose was to study the feasibility of determining individualized chemotherapy regimens by in vitro drug sensitivity testing (DST) for patients with limited-stage small cell lung cancer (SCLC) and to evaluate patient response and survival. Fifty-four previously untreated patients with limited-stage small cell cancer were studied. Fresh tumor specimens for DST were collected, when possible, from patients' biopsies before the start of treatment. The differential staining cytotoxicity assay was used to determine the in vitro sensitivity of the tumor cells to different drugs. From these results, an in vitro best regimen (IVBR), a three-drug combination of previously proven efficacy of seven active drugs in SCLC, was selected. Patients were initially treated with four cycles of etoposide/cisplatin and concurrent radiotherapy. This was followed by four cycles of either individualized chemotherapy regimens based on the results of DST or, when DST results were not available, four cycles of vincristine, doxorubicin, and cyclophosphamide. Eighteen patients (33%) underwent biopsy procedures that provided tissue specimens for DST. The biopsy specimens contained tumor cells in 16 of 18 patients. The median duration from diagnosis to start of treatment was 22 days (range, 4-58 days) for the 18 patients who underwent elective thoracic biopsies compared to 21 days (range, 2-74 days) for members of the group that did not (P2 = 0.58). Time from thoracic biopsy to initiation of chemotherapy was a median of 4 days (range, 2-22 days). DST was done in 10 patients, and IVBR was administered to 8 patients. The median actuarial survival of 8 patients treated with their IVBR was 38.5 months compared to 19 months for the 46 patients treated with empiric chemotherapy. Selection of individualized chemotherapy regimens is labor intensive but feasible in limited-stage SCLC. Treatment with an individualized IVBR in our patients was associated with prolonged patient survival; however, because of the nature of our study design, other factors could have affected the results.
Sensorial Contribution and Formation Pathways of Thiols in Foods: A Review (2005)

Since the mid-1990s, more than 300 publications have been devoted to the organoleptic relevance of thiols in foods (meats, wines, fruits). The available data about their physicochemical and sensorial properties, occurrence in foods, and potential formation pathways are compiled in this article.
Stress and wound healing (1979)

An experiment was performed to compare the effects of stressors--cold, heat and noise--on primary wound activity (i.e., wound closure in the first 24 h after wound infliction) and on rate of healing in mice. A significant correlation was found between reduced primary wound activity and a faster rate of healing. Conversely, a correlation was found between relatively greater primary wound activity and a slower rate of healing. A possible explanation of this correlation is a compensatory mechanism inherent to the skin healing process. This mechanism is visualized as (1) stress exposure affecting the skin by (a) causing it to become thinner and tauter and (b) causing it to have less elastic recoil; therefore, (2) when a square wound is produced in stressed skin, (a) the wound does not recoil readily or gapes soon after cutting and (b) a longer wound perimeter results. Because there is evidence that rate of healing is governed by cells on the wound perimeter, the greater the perimeter, the greater the number of cells that will undergo rapid mitosis and the faster will be the rate of healing. Therefore, stressed skin will heal at a faster rate, compensating for the loss of elasticity and cellular depletion caused by stress. This study is of interest to anthropology because it deals with dynamic adaptation, trying to grasp the meaning of the elusive endocrine interface between environmental stimulation and a measurable physical entity like healing. This work may have revealed a functional complex that is common to the healing of all mammalian skin, whereby retarding effects of stress on the healing process are obviated.
Numerical Performance Simulation of a Wetted Wall Bioaerosol Sampling Cyclone (2007)

Computational fluid dynamics techniques are used to study the performance of an axial flow bioaerosol sampling cyclone that continuously collects particles onto a flowing liquid film. A special shell-volume concept was developed to study formation and development of the liquid film on the inner wall of the cyclone. For a previous version of the cyclone, simulations demonstrated the presence of a ring of liquid in the region just upstream of the liquid skimmer that was suspected of causing liquid carryover into the exhaust air stream and degradation in aerosol collection efficiency. This ring was eliminated by re-design of the cyclone. For the upgraded version of the cyclone, CFD was used to successfully predict aerosol collection efficiency and cyclone pressure drop. The simulations reveal a complex flow evolution inside the cyclone. Stream-tubes are used to describe a significant narrowing of the width of the airflow as it enters the cyclone and an inward displacement of the flow as it travels in the axial direction. The particle deposition occurs primarily in a region that is subtended approximately by the length of the rectangular entrance slot and the first half turn of the flow in the cyclone. Cutpoint Stokes number is about 0.05 and the cutpoint particle size is about 1 μm aerodynamic diameter. At a flow rate of 1250 L/min, the pressure drop across the cyclone is 5.6 kPa (22 inches of water).
Exemplar-Based Sparse Representations for Noise Robust Automatic Speech Recognition (2011)

This paper proposes to use exemplar-based sparse representations for noise robust automatic speech recognition. First, we describe how speech can be modeled as a linear combination of a small number of exemplars from a large speech exemplar dictionary. The exemplars are time-frequency patches of real speech, each spanning multiple time frames. We then propose to model speech corrupted by additive noise as a linear combination of noise and speech exemplars, and we derive an algorithm for recovering this sparse linear combination of exemplars from the observed noisy speech. We describe how the framework can be used for doing hybrid exemplar-based/HMM recognition by using the exemplar-activations together with the phonetic information associated with the exemplars. As an alternative to hybrid recognition, the framework also allows us to take a source separation approach which enables exemplar-based feature enhancement as well as missing data mask estimation. We evaluate the performance of these exemplar-based methods in connected digit recognition on the AURORA-2 database. Our results show that the hybrid system performed substantially better than source separation or missing data mask estimation at lower signal-to-noise ratios (SNRs), achieving up to 57.1% accuracy at SNR = -5 dB. Although not as effective as two baseline recognizers at higher SNRs, the novel approach offers a promising direction of future research on exemplar-based ASR.
Anti-Leu3a Induces Combining Site-Related Anti-idiotypic Antibody Without Inducing Anti-HTV Activity (1991)

Development of a vaccine for acquired immunodeficiency syndrome (AIDS) has proven difficult, and so alternative approaches such as idiotypic manipulation have been suggested. As applied to AIDS, this approach could involve immunizing with an anti-CD4 antibody resembling gp120, to induce anti-idiotypic antibodies which would bind to gp120. The CD4 binding site on gp120 is conserved, and so, such an immune response should protect against all variants. Induction of anti-human immunodeficiency virus (HIV) immunity has been reported using anti-Leu3a, and this result has led to testing in humans. Negative results obtained by others have been attributed to differences in immunization protocols. Because of the importance of this question, we reinvestigated the potential of anti-Leu3a to induce anti-HIV antibodies, compared with control immunizations with OKT4A (another anti-CD4 antibody) and the irrelevant Ig MOPC-21. Responses to anti-Leu3a showed induction of high-titer anti-idiotypic activity, and included combining-site-related activity. Yet sera showed no binding to gp160 above controls and no detectable neutralizing activity in a sensitive HIV plaque assay, so the anti-idiotypes induced were not internal images of CD4. We conclude that the pronounced anti-HIV responses reported with anti-Leu3a cannot be generalized, and thus that anti-Leu3a does not offer promise as an HIV vaccine. However, these results do not negate the promise of the idiotypic approach, and a vaccine for AIDS based on idiotype manipulation remains a possibility.
Designed Amino Acid ATRP Initiators for the Synthesis of Biohybrid Materials (2007)

A synthetic strategy to prepare peptide-polymer conjugates with precise sites of attachment is described. Amino acids modified with atom transfer radical polymerization (ATRP) initiators for the polymerization of styrenes and methacrylates were prepared. Fmoc-4-(1-chloroethyl)-phenylalanine (5) was synthesized in four steps from Fmoc-tyrosine. HATU-mediated amidation with glycine-OMe resulted in dipeptide (6). The initiator was effective for Cu(I)/bipyridine mediated bulk polymerization of styrene. Kinetic studies indicated a controlled polymerization, with high conversion (97%), and a polydispersity index (PDI) of 1.25. Fmoc-O-(2-bromoisobutyryl)-serine tert-butyl ester (10) was synthesized from Fmoc-Ser(OTrt)-OH in three steps. This initiator was employed in the ATRP of 2-hydroxyethyl methacrylate (HEMA), and kinetic studies indicated a controlled polymerization. Different monomer to initiator ratios resulted in poly(HEMA) of different molecular weights and narrow PDIs (1.14-1.25). Conversions were between 70 and 99%. HEMA modified with N-acetyl-D-glucosamine (GlcNAc) was also polymerized to 84% conversion and the resulting PDI was 1.19. The t-butyl ester protecting group of 10 was removed, and the resulting amino acid (11) was incorporated into VM(11)VVQTK by standard solid-phase peptide synthesis. Polymerization resulted in the glycopolymer-peptide conjugate in 93% conversion and a PDI of 1.14.
Local Maximum Acceleration Based Rotating Machinery Fault Classification Using KNN (2019)

Rotating machinery are continuously operated tools for power generation and mechanical applications. The smooth operation of these tools is fundamental in businesses to accomplish their profitability. The status of such machines can be monitored by continuously assessing their working parameters that aid to identify abnormal behaviors. Upon detection of abnormal behaviors, such machines can be early scheduled for maintenance. Conditioned Based Maintenance (CBM) is one such approach that continuously monitors the machine and recommends taking action before equipment fails. This approach uses monitoring parameters such as temperature, pressure, and vibration signals to minimize unnecessary breakdown and catastrophic failure. Vibration parameters based machine fault identification approach is one of the widely used methods in CBM. Various machine malfunctions can be predicted and detected based on energy at specific frequencies of vibration signals. Common faults such as unbalanced and misalignment are often identified by examining the operating frequencies and their harmonics. Based on machine malfunctions, the dominant differences are expected at these frequencies. Barring few dominating peaks, other peaks are not exactly located at harmonic speed, so it can be misleading to use information from only harmonic speed. Rather than just examining operating frequencies and their harmonics, we looked at the local peaks and identified their frequencies. The acceleration amplitude at the operating speed and the local maximum acceleration amplitude are selected as a vibration feature for the fault classification. The proposed KNN classifier demonstrated its reliability with an accuracy of over 96% for the tested data set of 25 samples.
Optically induced femtosecond electromagnetic pulses from GaSb/AlSb strained-layer superlattices (1990)

The strain generated electric field in a 〈111〉 oriented misfit superlattice provides a suitable bias for generating optically induced femtosecond electromagnetic radiation. We have measured the electromagnetic radiation from GaSb/AlSb strained-layer superlattices and GaSb thin films; extremely fast electromagnetic pulses from 〈111〉 oriented superlattices have been observed. Because the quantum well structure in the superlattice samples limits the pulse duration of the transient photocurrent, it is possible to generate electromagnetic radiation having a pulse duration comparable with the photocarrier transit time across the quantum well.
Accelerated Life Test with Some Parameter Change in Life-Stress Relation (1997)

In most literature, accelerated life testing (ALT) models always assume the parameters in the life-stress relation remain unchanged under all stress levels. But in many practical situations, the upper bound of the stress levels under which such parameters keep unchanged is often unknown. In this paper we study the situation that the life-stress relation keeps unchanged, however, some parameters involved may be changed if it is over-stressed. A general method is propsed to consider such situations.
Human Natural Killer Cells: Origin, Receptors, Function, and Clinical Applications (2014)

Natural killer (NK) cells are important effectors playing a relevant role in innate immunity, primarily in tumor surveillance and in defenses against viruses. Human NK cells recognize HLA class I molecules through surface receptors (KIR and NKG2A) that inhibit NK cell function and kill target cells that have lost (or underexpress) HLA class I molecules as it occurs in tumors or virus-infected cells. NK cell activation is mediated by an array of activating receptors and co-receptors that recognize ligands expressed primarily on tumors or virus-infected cells. In vivo anti-tumor NK cell activity may be suppressed by tumor or tumor-associated cells. Alloreactive NK cells (i.e. those that are not inhibited by the HLA class I alleles of the patient) derived from HSC of haploidentical donors play a major role in the cure of high-risk leukemia, by killing leukemia blasts and patient's DC, thus preventing tumor relapses and graft-versus-host disease. The expression of the HLA-C2-specific activating KIR2DS1 may also contribute to NK alloreactivity in patients expressing C2 alleles. A clear correlation has been proven between the size of the alloreactive NK cell population and the clinical outcome. Recently, haplo-HSCT has been further improved with the direct infusion, together with HSC, of donor-derived, mature alloreactive NK cells and TCRγδ(+) T cells - both contributing to a prompt anti-leukemia effect together with an efficient defense against pathogens during the 6- to 8-week interval required for the generation of alloreactive NK cells from HSC.
Leveling the Playing Field: Bringing Development of Biomarkers and Molecular Diagnostics up to the Standards for Drug Development (2012)

Molecular diagnostics are becoming increasingly important in clinical research to stratify or identify molecularly profiled patient cohorts for targeted therapies, to modify the dose of a therapeutic, and to assess early response to therapy or monitor patients. Molecular diagnostics can also be used to identify the pharmacogenetic risk of adverse drug reactions. The articles in this CCR Focus section on molecular diagnosis describe the development and use of markers to guide medical decisions regarding cancer patients. They define sources of preanalytic variability that need to be minimized, as well as the regulatory and financial challenges involved in developing diagnostics and integrating them into clinical practice. They also outline a National Cancer Institute program to assist diagnostic development. Molecular diagnostic clinical tests require rigor in their development and clinical validation, with sensitivity, specificity, and validity comparable to those required for the development of therapeutics. These diagnostics must be offered at a realistic cost that reflects both their clinical value and the costs associated with their development. When genome-sequencing technologies move into the clinic, they must be integrated with and traceable to current technology because they may identify more efficient and accurate approaches to drug development. In addition, regulators may define progressive drug approval for companion diagnostics that requires further evidence regarding efficacy and safety before full approval can be achieved. One way to accomplish this is to emphasize phase IV postmarketing, hypothesis-driven clinical trials with biological characterization that would permit an accurate definition of the association of low-prevalence gene alterations with toxicity or response in large cohorts.
Simulation and measurement of an Internet of Things implementation of a programmable digital inductor (2016)

The theory, design, and implementation of a programmable Internet of Things digital inductor circuit is presented. Since the inductor is implemented in digital signal processing, the values for the inductance are easily modifiable through an Internet of Things interface, enabling remote access to the physical hardware. The system was implemented on a commercially-available microcontroller board using a client-server scheme over ethernet connection. A control interface running on a laptop was then used to change the inductance remotely. Simulation and implementation of the design are presented and are shown to match at a sample rate of 100 kilosamples per second. Since the design method constitutes a digital approach, performance is expected to scale with higher-speed hardware.
Absolute quantification of microbial taxon abundances (2016)

High-throughput amplicon sequencing has become a well-established approach for microbial community profiling. Correlating shifts in the relative abundances of bacterial taxa with environmental gradients is the goal of many microbiome surveys. As the abundances generated by this technology are semi-quantitative by definition, the observed dynamics may not accurately reflect those of the actual taxon densities. We combined the sequencing approach (16S rRNA gene) with robust single-cell enumeration technologies (flow cytometry) to quantify the absolute taxon abundances. A detailed longitudinal analysis of the absolute abundances resulted in distinct abundance profiles that were less ambiguous and expressed in units that can be directly compared across studies. We further provide evidence that the enrichment of taxa (increase in relative abundance) does not necessarily relate to the outgrowth of taxa (increase in absolute abundance). Our results highlight that both relative and absolute abundances should be considered for a comprehensive biological interpretation of microbiome surveys.