gebhart/patrepeval huggingface dataset:
[Guideline conformity and outcome of inpatient treatment for schizophrenia. A clinical comparison]. (2005)

Patient outcome and guideline conformity in inpatient schizophrenia treatment was systematically evaluated and compared with 597 patients across seven psychiatric hospitals. Patient structure and treatment processes showed a great variability between hospitals. Patient characteristics, especially mental state, and the chronicity of the disease were the strongest predictors of clinical outcome. Outcome evaluation using quality indicators is only possible after case-mix adjustment taking into account prognostic factors. A poorer average clinical outcome was associated with lower guideline conformity in a variety of treatment domains. After case-mix adjustment, benchmarking is an opportunity to improve quality of treatment and promote guideline conformity.
A coarse-grained dynamically reconfigurable architecture for digital signal processing (2009)

This paper presents design and implementation of a coarse-grained reconfigurable architecture, targeting digital signal processing applications. The proposed architecture is constructed from a mesh of resource cells, containing the separated processing and memory elements that communicate via a hybrid interconnect network. Parameterizable design of resource cells enables flexible static mapping of arbitrary applications, and the feature of dynamic reconfigurability provides mapping possibilities during system run-time to adapt to the current operational and processing conditions. Functionality is demonstrated by mapping a radix 22 FFT processor reconfigurable between 32 and 1,024 points. Performance evaluation exhibits a great reconfigurability and execution time reduction when compared to an ordinary DSP solution.
PREP AND KITT: COMPUTER CODES FOR THE AUTOMATIC EVALUATION OF A FAULT TREE. (1970)

path set, and for the system. Exact, time-dependent reliability information is determined for each component and for each minimal cut set or path set. For the system, reliability results are obtained by upper bound approximations or by a bracketing procedure in which various upper and lower bounds may be obtained as close to one another as desired. The KITT programs can handle independent components which are nonrepairable or which have a constant repair time. Any assortment of nonrepairable components and components having constant repair times can be considered. Any inhibit conditions having constant probabilities of occurrence can be handled. The failure intensity of each component is assumed to be constant with respect to time. The KITT2 program can also handle components which during different time intervals, called phases, may have different reliability properties.IBM360;UNIVAC1108; FORTRAN IV; OS/360 MVT (IBM360); 350K bytes on the IBM360.
Conductive Polymers: Opportunities and Challenges in Biomedical Applications (2018)

Research pertaining to conductive polymers has gained significant traction in recent years, and their applications range from optoelectronics to material science. For all intents and purposes, conductive polymers can be described as Nobel Prize-winning materials, given that their discoverers were awarded the Nobel Prize in Chemistry in 2000. In this review, we seek to describe the chemical forms and functionalities of the main types of conductive polymers, as well as their synthesis methods. We also present an in-depth analysis of composite conductive polymers that contain various nanomaterials such as graphene, fullerene, carbon nanotubes, and paramagnetic metal ions. Natural polymers such as collagen, chitosan, fibroin, and hydrogel that are structurally modified for them to be conductive are also briefly touched upon. Finally, we expound on the plethora of biomedical applications that harbor the potential to be revolutionized by conductive polymers, with a particular focus on tissue engineering, regenerative medicine, and biosensors.
Design, Synthesis, and Enzymatic Evaluation of <i>N</i>-Acyloxyalkyl- and <i>N</i><sup>1</sup>-Oxazolidin-2,4-dion-5-yl-Substituted β-lactams as Novel Inhibitors of Human Leukocyte Elastase (2005)

Human leukocyte elastase (HLE) is a serine protease that very efficiently degrades various tissue matrix proteins such as elastin. The imbalance between HLE and its endogenous inhibitors leads to excessive elastin proteolysis and is considered to be responsible for the onset of chronic obstructive pulmonary disease (COPD). A novel series of C-3-, C-4-, and N-1-substituted azetidin-2-ones were prepared as potential mechanism-based inhibitors of HLE to restore the protease/antiprotease imbalance. N-Acyloxyalkylazetidin-2-ones, 4, and their carbamate counterparts, 5, are weak HLE inhibitors, being 5 times less active than their bicyclic oxazolidin-2,4-dione-substituted analogues, 6, containing an electron-withdrawing substituent at C-4. Compounds 6 containing a C-4 substituent exist as two diastereomeric pairs of enantiomers, each pair presenting similar inhibitory activity against HLE. Comparative docking experiments with the C-4-substituted oxazolidin-2,4-dione inhibitors 6 suggest that only the 4R,5'S and 4S,5'S diastereomers consistently interact with the beta-lactam carbonyl carbon atom accessible to the serine hydroxyl oxygen.
Analysis of Microarrays by MALDI‐TOF MS (2013)

Ligand libraries can be printed onto a sandwich composed of activated lipids embedded in a hydrophobic layer conjugated to an indium-tin oxide (ITO) surface. Arrays produced this way can be analyzed by fluorescence spectroscopy and mass spectrometry. Applications include the assignment of enzyme specificity, the profiling of glycoforms and the identification of lectins.
Forecasting Economic Time Series (1979)

Economic Theory, Econometrics, and Mathematical Economics, Second Edition: Forecasting Economic Time Series presents the developments in time series analysis and forecasting theory and practice. This book discusses the application of time series procedures in mainstream economic theory and econometric model building. Organized into 10 chapters, this edition begins with an overview of the problem of dealing with time series possessing a deterministic seasonal component. This text then provides a description of time series in terms of models known as the time-domain approach. Other chapters consider an alternative approach, known as spectral or frequency-domain analysis, that often provides useful insights into the properties of a series. This book discusses as well a unified approach to the fitting of linear models to a given time series. The final chapter deals with the main advantage of having a Gaussian series wherein the optimal single series, least-squares forecast will be a linear forecast. This book is a valuable resource for economists.
Peroxisome proliferator-activated receptor γpolymorphism Pro12Ala is associated with nephropathy in type 2 diabetes (2010)

Objective: Insulin resistance plays a part in diabetic nephropathy (DN). The association between the peroxisome proliferator-activated receptor ? Pro to Ala alteration at codon 12 (Pro12Ala) polymorphism and the risk of insulin resistance has been confirmed. The association between the polymorphism and DN risk has also been widely studied recently, but no consensus was available up to now. Research Design and Methods: A systematic search of electronic databases (MEDLINE, Embase, and China National Knowledge Infrastructure) and reference lists of relevant articles was carried out, and then 18 case-control studies involving 3,361 DN cases and 5,825 control subjects were identified. RESULTS In the overall analysis, the Ala12 variant was observed to be significantly associated with decreased DN risk (odds ratio 0.76 [95% CI 0.61-0.93]). Some evidence of heterogeneity among the included studies was detected, which could be explained by the difference of ethnicity and stage of DN. Subgroup analyses stratified by ethnicity and stage of DN were performed, and results indicated the Pro12Ala polymorphism was associated with the risk of DN in Caucasians but no similar association was observed in Asians. Additionally, we observed that Ala12 was associated with decreased risk of albuminuria. With only a few of subjects were available, we failed to detect statistically significant association between the polymorphism and end-stage renal disease (ESRD). Conclusions: Our results indicated that the Ala12 variant is a significantly protective factor for DN. Future research should focus on the effect of Pro12Ala polymorphism on ESRD and gathering data of Africans.
TOEFIT-PLUS System for Replacement of the First Metatarsophalangeal Joint (2010)

Our results with the use of TOEFIT-PLUS replacement show that this implant is effective in the treatment of hallux rigidus advanced stages and has good clinical outcomes, i.e., maintenance of motion at the MTP joint of the big toe, pain alleviation and early weight bearing. Since hemiarthroplasty is associated with fewer complications whose potential treatment is easier, this approach seems to have a better prospect than total joint replacement.
Probability estimation in arithmetic and adaptive-Huffman entropy coders (1995)

Entropy coders, such as Huffman and arithmetic coders, achieve compression by exploiting nonuniformity in the probabilities under which a random variable to be coded takes on its possible values. Practical realizations generally require running adaptive estimates of these probabilities. An analysis of the relationship between estimation quality and the resulting coding efficiency suggests a particular scheme, dubbed scaled-count, for obtaining such estimates. It can optimally balance estimation accuracy against a need for rapid response to changing underlying statistics. When the symbols being coded are from a binary alphabet, simple hardware and software implementations requiring almost no computation are possible. A scaled-count adaptive probability estimator of the type described in this paper is used in the arithmetic coder of the JBIG and JPEG image coding standards.
Aniline blue staining as a marker of sperm chromatin defects associated with different semen characteristics discriminates between proven fertile and suspected infertile men (1990)

A retrospective study of 49 men with proven fertility and 396 suspected infertile men was conducted with the primary objective of investigating the relationship between the nuclear maturity of sperm and male fertility. Acidic aniline blue staining was used to detect chromatin defects of sperm nuclei related to their nucleoprotein content as associated with DNA. The discriminant value of the percentage of unstained nuclei (= percentage of mature heads, MH) and of other semen characteristics, was analysed by a stepwise (forward) linear regression model. Semen characteristics that discriminated significantly between the two groups of subjects were, in descending order: (1) the percentage of normal sperm, (2) the percentage of amorphous heads, (3) the percentage of tapered heads, (4) semen volume, and (5) the percentage of MH. The discriminant value of each of the significant characteristics was studied by means of ROC-curves. MH had the best ROC-curve profile; its cut-off value was found to be equal to 70% (74.5 +/- 2.6% for the donor group versus 53.0 +/- 1.1% for the patient group). A simple infertility score (SIS) including MH, was built according to the cut-off values inferred from the ROC-curves. SIS allowed an overall satisfactory separation of the two groups (less than or equal to 4 = fertile, 5-6 = uncertainty zone, greater than 6 = infertile). Our results indicate that the addition of the evaluation of sperm head maturity to routine semen analysis improves the assessment of fertility in men.
In Vitro Acclimatization of Aseptically Cultured Plantlets to Humidity (1983)

Abstract A method is described whereby relative humidity is reduced in the atmosphere of agar-solidified tissue cultures. Plantlets of chrysanthemum ( Chrysanthemum X morifolium Ramat.) cultured under low humidity exhibited a high mortality rate and those that survived were smaller and had few roots. Severe retardation of stomatal development occurred under reduced humidity and mature stomata had considerably narrower apertures than did plantlets grown at about 100% relative humidity. Plantlets of cauliflower ( Brassica oleracea L. Botrytis group) cultured under reduced humidity also exhibited reduced growth but, in addition, developed large quantities of surface wax and had lower rates of water loss. The results are discussed in relation to the potential uses of the technique for acclimatization of plantlets prior to transfer to soil.
Radioimmunotherapy of micrometastases in lung with vascular targeted213Bi (1999)

A model system has been used to test the efficacy of vascular targeting of alpha-particle emitter 213Bi for therapy of small, 'artificial' metastases in mouse lung. Specific monoclonal antibody (mAb) 201 B was used to deliver greater than 30% of the injected dose to lung where tumours had developed due to intravenous injection of cells. Specific 213Bi-mAb 201B treatment of BALB/c mammary carcinoma EMT-6 tumours in lung resulted in a dose-dependent destruction of tumours and an extended lifespan of treated animals relative to controls. Significant reduction of lung tumour burden was noted in animals treated with 0.93 MBq injected dose or as little as 14 Gy absorbed dose to the lung. Animals treated with higher doses (2.6-6.7 MBq) had nearly complete cure of lung tumours but eventually died of lung fibrosis induced by the treatment. Four other tumour cell types were studied: murine Line 1 lung carcinomas in syngeneic BALB/c mice, rat IC-12 tracheal carcinoma growing in severe combined immune deficient (SCID) mice, and two human tumours--epidermoid carcinoma A431 and lung carcinoma A549--growing in SCID mice. In all cases, the number of lung tumour colonies was reduced in animals treated with specific, labelled mAb relative to those in animals treated with control 213Bi MAb or EDTA complexed 213Bi. Tumours treated in immunodeficient SCID mice were partially destroyed or at least retarded in growth, but ultimately regrew and proved fatal, indicating that an intact immune function is necessary for complete cure. The data show that the short-lived alpha-particle emitter 213Bi can be effectively targeted to lung blood vessels and that tumour cells growing in the lung are killed. The mechanism may involve direct killing of tumour cells from alpha-particle irradiation, killing through destruction of blood supply to the tumour, or a combination of the two.
Correction of Geometric and Photometric Distortion of Document Images Using a Stereo Camera System (2007)

In this paper, we propose a new method for correcting distorted document images using a stereo camera pair. Geometric and photometric distortions may occur in document images of thick book pages because of its curved surfaces. The proposed method acquires document shape by stereo measurement to correct geometric distortions in images. By considering normal vectors of document surfaces, optimum-resolution images are generated as a combination of a stereo image pair. Moreover, the method corrects photometric distortions by analyzing lighting and reflecting conditions. The validity of the proposed method was shown through experiments. 1.
PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells (2015)

Tumour-initiating cells (TICs) are advocated to constitute the sustaining force to maintain and renew fully established malignancy; however, the molecular mechanisms responsible for these properties are elusive. We previously demonstrated that voltage-gated calcium channel α2δ1 subunit marks hepatocellular carcinoma (HCC) TICs. Here we confirm directly that α2δ1 is a HCC TIC surface marker, and identify let-7c, miR-200b, miR-222 and miR-424 as suppressors of α2δ1(+) HCC TICs. Interestingly, all the four miRNAs synergistically target PBX3, which is sufficient and necessary for the acquisition and maintenance of TIC properties. Moreover, PBX3 drives an essential transcriptional programme, activating the expression of genes critical for HCC TIC stemness including CACNA2D1, EpCAM, SOX2 and NOTCH3. In addition, the expression of CACNA2D1 and PBX3 mRNA is predictive of poor prognosis for HCC patients. Collectively, our study identifies an essential signalling pathway that controls the switch of HCC TIC phenotypes.
Predicting NCLEX-PN success with the HESI Exit Exam. (2010)

Surveys were mailed to directors of 72 randomly selected practical nursing (PN) schools that administered Elsevier's HESI Exit Exam for Practical Nurses (E2-PN) during the 2006-2007 academic year. Data were collected regarding students' NCLEX-PN outcomes and the schools' benchmarking and remediation policies. The first version of the E2-PN was 99.48% accurate in predicting NCLEX-PN success. Versions two and three of the E2-PN, which were administered to students who were remediated because they did not achieve the faculty-designated benchmark, were also highly accurate in predicting NCLEX-PN success. Most faculties set 850 as their school's E2-PN benchmark, and 73% of the respondents required remediation for students who did not achieve the benchmark score. The most frequently cited remediation strategy was tutoring.
21st Century Marketing Using Communication Modes by Students in Accessing Their Information Needs at Two Selected Study Center Libraries in Southwest of National Open University of Nigeria (2018)

This paper examined marketing in the 21st century using communication modes in accessing information needs of students in two study centre libraries of National Open University of Nigeria. A descriptive research design was used for this study and the instrument for data collection was a questionnaire, observation and interview. A total of 60 copies of the questionnaire were administered to students, from faculties of Agricultural Sc., Management Sc., Social Sc., Health Sc., Law, Education, Science & Technology, but 56 were retrieved and used for the analysis. Purposeful and stratified random sampling technique was used for this research. Findings from the demographic data show more male than female students between the age brackets of 21-25 years, with higher percentage than other ages. Result from findings shows that faculty of social science has greater percentage of students than other faculties and higher undergraduates than post graduate students. Data analysis show awareness on student use of library resources before and after marketing as medium, while social media , the use of course materials and past question papers were discovered to have greater impact at student in accessing their information needs. Lack of internet connectivity was a major hindrance by students in accessing available electronic resources at both study center libraries. University management must ensure unlimited internet connectivity in all study centers.
Molecular analysis of urease genes from a newly identified uncultured species of Helicobacter (1994)

"Gastrospirillum hominis" is an uncultured gastric spiral bacterium that has recently been shown by 16S rDNA sequence analysis to be a newly recognized species of Helicobacter that infects humans, and it has been provisionally designated "Helicobacter heilmannii." We used PCR to directly amplify the urease structural genes of "H. heilmannii" from infected gastric tissue. DNA sequence analysis identified two open reading frames, ureA and ureB, which code for polypeptides with predicted molecular weights of 25,729 and 61,831, respectively. The urease subunit genes from "H. heilmannii" were cloned and expressed in Escherichia coli. Western blot (immunoblot) analysis showed that antiserum directed against the ureA and ureB gene products from H. pylori was cross-reactive with the corresponding polypeptides from "H. heilmannii." Analysis of the derived amino acid sequences of "H. heilmannii" UreA and UreB demonstrated that "H. heilmannii" urease is more highly related to the urease from H. felis (found in the stomachs of cats and dogs) than to the urease from H. pylori. These data are consistent with 16S rDNA sequence analysis and suggest that "H. heilmannii" is phylogenetically most closely related to H. felis.
METAlex: Legislation in XML (2002)

This paper presents a proposal for an open XML standard for the markup of legal documents: META Lex. The standard provides a generic and easily extensible framework for the XML encoding of the structure and contents of legal and paralegal documents. It differs from other existing metadata schemes in two respects: It is language and jurisdiction independent and it aims to accommodate uses of XML beyond search and presentation services.
Occurrence of a hormone-sensitive inhibitory coupling component of the adenylate cyclase in S49 lymphoma cyc- variants. (1983)

The influence of somatostatin was studied on cyclic AMP levels and adenylate cyclase activity in cyc- variants of S49 lymphoma cells. These cells are deficient in the guanine nucleotide site that mediates hormone-induced adenylate cyclase stimulation, but their cyclase can be stimulated by forskolin. Somatostatin maximally decreased the 30 microM forskolin-stimulated cyclic AMP levels by 35%. Half-maximal suppression occurred at about 0.1 nM somatostatin. Somatostatin (up to 1 microM) had no effect on the 100 microM forskolin-stimulated adenylate cyclase activity in cyc- membrane preparations when guanine nucleotides were not present. In the presence of GTP, however, which by itself caused a small decrease in activity, somatostatin maximally inhibited the enzyme by 20-25%. GTP was half-maximally effective at 0.1 microM, and half-maximal inhibition by somatostatin was observed at 0.1- 1 nM. In the presence of the stable GTP analog guanosine 5'-O-(3-thiotriphosphate) (1 microM), which decreased the stimulated activity by about 40% after a short lag period, somatostatin (1 microM) did not cause a further decrease in final activity but reduced the lag period by about 50%. The data indicate that membranes of cyc- variants contain a regulatory site that mediates both guanine nucleotide and hormone-induced inhibition of the adenylate cyclase and suggest that the mechanisms of activation and inactivation of this inhibitory site are similar to those of the stimulatory component missing in cyc-membranes.
Solubility of hydrogen sulfide in n-eicosane at elevated pressure (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubility of hydrogen sulfide in n-eicosane at elevated pressureGuo Xiang Feng and Alan E. MatherCite this: J. Chem. Eng. Data 1992, 37, 4, 412–413Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/je00008a009https://doi.org/10.1021/je00008a009research-articleACS PublicationsRequest reuse permissionsArticle Views171Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts