gebhart/patrepeval huggingface dataset:
Optical fibers for improved low-loss coupling of optical components (2004)

An important feature of achieving low coupling losses in systems with small dimensions is the availabilty of optical fibers with larger numerical apertures while retaining the excellent loss characteristics of synthetic silica. Larger acceptance angles permit more efficient pick up of signals in smaller diameter optical fibers. Likewise broader angles can benefit illumination systems, providing larger areas of coverage with smaller components. Examples where one or both aspects are valuable include remote spectroscopic sampling and hands-free fiber optic illumination systems for hazardous environments. Optical fibers with doped synthetic silica cores are described which have numerical apertures of over 0.50 for power delivery and effective NAs approaching 0.60 for illumination, sensing or other 'low power' applications. Spectral and optical properties of these fivers are presented along with how they allow improved low loss coupling of optical components in photonic and microelectronic systems.
Liquid chromatographic determination of cyclophosphamide enantiomers in plasma by precolumn chiral derivatization (1989)

On the basis of reactions described in the synthetic literature, a two-step chiral derivatization sequence was developed for the anticancer agent cyclophosphamide (CP). The sequence involves amidoalkylation of CP with anhydrous chloral containing 1% dimethylformamide followed by acylation of the resulting secondary alcohol with a chiral carboxylic acid chloride, (+)-6-methoxy-alpha-methyl-2-naphthaleneacetyl chloride, to form a diastereomeric pair. Derivatized (-)-CP and (+)-CP exhibited retention times of 17.2 and 20.7 min, respectively, when chromatographed on Hypersil ODS with acetonitrile/phosphate buffer (pH 6.8) as the mobile phase. Preparation of the individual diastereomers from enantiomerically pure CP enabled correlation of the chromatographically observed peaks with a particular enantiomer. Various aspects of the overall assay methodology have been systematically investigated (derivatization solvents, temperatures, reaction time, and work-up procedure) and optimized on the scale required for trace analysis in biological fluids. Calibration curves were established for each enantiomer in spiked human plasma over the therapeutically relevant concentration range of 0.99-49.94 micrograms/mL.
Bis-boranes in the frustrated Lewis pair activation of carbon dioxide (2011)

Using a frustrated Lewis pair approach, the 1,1-bis-(C(6)F(5))(2)BOB(C(6)F(5))(2) is shown to bind CO(2) in a monodentate fashion, while the bis-boranes (X(2)B)(2)C=CMe(2) (X = Cl, C(6)F(5)) give bidentate chelation of CO(2) affording unique heterocycles.
15-Lipoxygenase products as leukotriene antagonists: therapeutic potential in glomerulonephritis. (1992)

In the first few hours following immune complex deposition and complement-mediated neutrophil (PMN) infiltration, glomerular generation rates of the arachidonate 5-lipoxygenase (5-LO) derivatives leukotrienes (LT) C4, D4, and B4 are stimulated markedly. These LTs exert effects on glomerular functions which include reduction in the glomerular ultrafiltration coefficient and glomerular filtration rates, exacerbation of proteinuria, and amplification of PMN-provoked glomerular damage through LTB4-induced PMN chemotaxis, adhesion, and activation. Following this early burst, glomerular LT synthesis is suppressed, macrophages replace PMNs, and glomerular generation of 15-S-hydroxyeicosatetraenoic acid [15-(S)-HETE], a 15-lipoxygenase derivative of arachidonic acid and a precursor molecule for lipoxin (LX) biosynthesis, increases progressively over the ensuing days to weeks. Here, we summarize evidence supporting the notion that the activation of the 15-LO pathway in the wake of early 5-LO activity is a specific counter-inflammatory signal which limits and antagonizes the proinflammatory actions of leukotrienes.
Inhibition and Restoration of Prolactin Signal Transduction by Suppressors of Cytokine Signaling (1999)

Prolactin (PRL) has been shown to activate the cytoplasmic tyrosine kinase Janus kinase 2 (Jak2) and the subsequent recruitment of various signaling molecules including members of the signal transducer and activator of transcription family of transcription factors. Recently, an expanding family of cytokine-inducible inhibitors of signaling has been identified that initially included four members: suppressor of cytokine signaling (SOCS)-1, SOCS-2, SOCS-3, and cytokine-inducible src homology domain 2 (SH-2) proteins. The present study analyzes the role of these members in PRL signaling. Constitutive expression of SOCS-1 and SOCS-3 suppressed PRL-induced signal transducer and activator of transcription 5-dependent gene transcription, and Jak2 tyrosine kinase activity was greatly reduced in the presence of SOCS-1 or SOCS-3. SOCS-1 was shown to associate with Jak2, whereas SOCS-2 was associated with the prolactin receptor. Co-transfection studies were conducted to further analyze the interactions of SOCS proteins. SOCS-2 was shown to suppress the inhibitory effect of SOCS-1 by restoring Jak2 kinase activity but did not affect the inhibitory effect of SOCS-3 on PRL signaling. Northern blot analysis revealed that SOCS-3 and SOCS-1 genes were transiently expressed in response to PRL, both in vivo and in vitro, whereas the expression of SOCS-2 and CIS genes was still elevated 24 h after hormonal stimulation. We thus propose that the early expressed SOCS genes (SOCS-1 and SOCS-3) switch off PRL signaling and that the later expressed SOCS-2 gene can restore the sensitivity of cells to PRL, partly by suppressing the SOCS-1 inhibitory effect.
Structure‐activity relationship in the induction of Epstein‐Barr virus by teleocidin derivatives (1985)

New derivatives of (-)-indolactam V (Fig. 1), which have the basic ring-structure of teleocidins without the monoterpenoid moiety, were prepared and their Epstein-Barr virus early antigen (EBV-EA)-inducing activity was tested. (-)-14-O-Alkyl indolactam Vs (2 and 3) showed little induction of EBV-EA, while (-)-14-dehydroxyindolactam V (4) and (-)-14-chloroindolactam V (5) proved to be potent EBV-EA inducers, though their activities (EC50) were about 10 times weaker than that of (-)-indolactam V (1). These results indicate that the hydroxyl group at C-14 is not indispensable for EBV-EA induction and can be replaced. The activities (EC50) of (-)-1-N-methyl, (-)-1-N-ethyl, and (-)-1-N-butyl indolactam V (10, 11, and 12) were about 5 times weaker than that of (-)-indolactam V (1), while (-)-1-N-hexyl and (-)-1-N-octyl indolactam V (13 and 14) were even less active, suggesting that the free imino group of the indole ring in (-)-indolactam V (1) plays an important role in the activity, and that the activity cannot be enhanced by alkylation at the N-1 position of (-)-indolactam V (1).
A novel carbon fiber based porous carbon monolith (1995)

A novel porous carbon material based on carbon fibers has been developed. The material, when activated, develops a significant micro- or mesopore volume dependent upon the carbon fiber type utilized (isotropic pitch or polyacrylonitrile). The materials will find applications in the field of fluid separations or as a catalyst support. Here, the manufacture and characterization of our porous carbon monoliths are described. A novel adsorbent carbon composite material has been developed comprising carbon fibers and a binder. The material, called carbon fiber composite molecular sieve (CFCMS), was developed through a joint research program between Oak Ridge National Laboratory (ORNL) and the University of Kentucky, Center for Applied Energy Research (UKCAER).
Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells (2006)

Fucoxanthin is a major carotenoid found in edible seaweed such as Undaria pinnatifida and Hijikia fusiformis. We investigated the suppressive effects of fucoxanthin and its metabolite, fucoxanthinol, on the differentiation of 3T3-L1 preadipocytes to adipocytes. Fucoxanthin inhibited intercellular lipid accumulation during adipocyte differentiation of 3T3-L1 cells. Furthermore, fucoxanthin was converted to fucoxanthinol in 3T3-L1 cells. Fucoxanthinol also exhibited suppressive effects on lipid accumulation and decreased glycerol-3-phosphate dehydrogenase activity, an indicator of adipocyte differentiation. The suppressive effect of fucoxanthinol was stronger than that of fucoxanthin. In addition, in 3T3-L1 cells treated with fucoxanthin and fucoxanthinol, peroxisome proliferator-activated receptor gamma (PPARgamma), which regulates adipogenic gene expression, was down-regulated in a dose-dependent manner. These results suggest that fucoxanthin and fucoxanthinol inhibit the adipocyte differentiation of 3T3-L1 cells through down-regulation of PPARgamma. Fucoxanthinol had stronger suppressive effects than fucoxanthin on adipocyte differentiation in 3T3-L1 cells.
ECOLOGY OF ACTINOMYCETES (1983)

Les actinomycetes sont tres largement distribues dans les ecosystemes terrestres et les ecosystemes aquatiques. Ils incluent aussi des zoopathogenes et des phytopathogenes
New biobased epoxy materials from cardanol (2013)

Commercial epoxidized cardanol, from cashew nut shell liquid (CNSL), is a biobased epoxide reactant with interesting aromatic structure. Epoxidized cardanol was thoroughly analyzed using 1 H and 13 C NMR, size exclusion chromatography, and titration in order to determine the structure. This epoxidized cardanol was reacted with isophorone diamine and Jeffamine D400 diamine in order to synthesize epoxy networks. These epoxy networks, formulated in stoichiometry ratio, were characterized by differential scanning calorimetry, thermogravimetric analysis, dynamic mechanical analysis analyses and were compared to bisphenol A diglycidyl ether (DGEBA) network. Cardanol‐based epoxy materials exhibit interesting mechanical and thermal properties for coatings. Practical application: The reactant described in this contribution, i.e. epoxidized cardanol from CNSL, provides biobased aromatic building blocks for further epoxy resin syntheses by reaction with amine hardeners. The obtained epoxy networks are partially biobased and may be applied as binders and coatings.
Teledentistry the future of dental practice (2013)

Teledentistry is a synergistic combination of telecommunications technology, Internet and dental practice. It is a relatively new and exciting field that combines telecommunication technology and dental care. Teledentistry increased patient access to dental care, improved quality of care and the cost effectiveness. Teledentistry is also useful in long-distance clinical training and continuing education, screening and dentist laboratory communication. Some barriers still exist for teledentistry practice, including educational, legal and insurance issues. The purpose of this article is to highlight the various aspects on teledentistry.
Natural history of mild cognitive impairment in older persons (2002)

Mild cognitive impairment is associated with an increased risk of death and incident AD, and a greater rate of decline in selected cognitive abilities.
Studies of the Mixed Amino-acid Complexes of Cobalt(III). I. The Geometrical Isomers of the [Co en gly (chelate)] Series (1966)

Abstract Five new complexes of the [Co en gly (chelate)] type, i. e., mer(N)- and fac(N)-[Co en gly CO3], mer(N)- and fac(N)-[Co en gly ox] and mer(N)-[Co en gly malo], have been derived from a new dinitro complex, cis-[Co en gly (NO2)2], through an intermediate complex, [Co en gly Cl (OH2)]Cl. The geometrical structures of these complexes have been determined on the basis of the processes of their derivation and their absorption spectra. Two new bisglycinato complexes, trans(O)- and cis(O)-[Co en gly2]I·H2O, have been prepared from mer(N)- and fac(N)-[Co en gly CO3] respectively.
Bend sensor arrays for hand movement tracking in biomedical systems (2011)

Bend sensor's electrical feature and mechanical pliability allow to easily realize a cost effective and reliable system to measure human postures. With this kind of sensors we realized a data glove capable to accurately measure all degree of freedom of a human hand. In particular, in collaboration with the Flexpoint Sensor Systems Inc., we designed and realized a unique device capable to measure at the same time the flex-extension movements of the three joints of one finger. Experimental results demonstrated good performances obtained in terms of accuracy and repeatability of the measures.
Negative ion mobility spectrometry for selected inorganic pollutant gases and gas mixtures in air (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNegative ion mobility spectrometry for selected inorganic pollutant gases and gas mixtures in airG. A. Eiceman, C. S. Leasure, and V. J. VandiverCite this: Anal. Chem. 1986, 58, 1, 76–80Publication Date (Print):January 1, 1986Publication History Published online1 May 2002Published inissue 1 January 1986https://pubs.acs.org/doi/10.1021/ac00292a019https://doi.org/10.1021/ac00292a019research-articleACS PublicationsRequest reuse permissionsArticle Views246Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Highly Efficient Fullerene-Free Organic Solar Cells Operate at Near Zero Highest Occupied Molecular Orbital Offsets (2019)

Herein, we investigated a series of fullerene-free organic solar cells (OSCs) based on six different donor:acceptor (D:A) blends with varied highest occupied molecular orbital (HOMO) offsets from -0.05 to 0.21 eV. First, to verify the energetic compatibility of a specific D:A pair, especially for HOMO offsets, we established a simple method to estimate the hole transfer tendencies between D and A by using bilayer hole-only devices. It reveals that the asymmetrical diode effect of the bilayer hole-only devices can correlate with the FF and J<sub>sc</sub> of the relevant OSCs. Second, to find out whether HOMO offset is the main restriction of hole transfer, we measured transient absorption spectra and examined the hole transfer behavior in the blends, revealing that the occurrence of hole transfer is independent of the HOMO offsets and ultrafast in the time scale of ≤4.6 ps for those blends with ≥0 eV HOMO offsets. In contrast, a negative HOMO offset can significantly slow down the hole transfer with a half-time of ∼400 ps. Furthermore, we compare the device parameters under varied light intensities and discover that the bimolecular recombination should be one of the main restrictions for high device performance. Surprisingly, small HOMO offsets of 0 and 0.06 eV can also enable high PCEs of 10.42% and 11.75% for blend 2 (PTQ10:HC-PCIC) and blend 3 (PBDB-TF:HC-PCIC), respectively. Overall, our work demonstrates not only the validity of high-performance OSCs operating at the near zero HOMO offsets but also the charge dynamic insights of these blends, which will help gain understanding on the further improvement of OSCs.
Pregnancy outcomes in healthy nulliparas who developed hypertension (2000)

Hypertension, especially severe hypertension, was associated with an appreciable increase in important maternal and perinatal morbidity but not perinatal mortality.
Experimental Study on the Effect of Coil Spring Reaction Force Vector on McPherson Strut Suspension Characteristics (2014)

<div class="section abstract"><div class="htmlview paragraph">In McPherson strut applications for automotive suspension systems, the desired coil spring reaction force vector (FLP: force line position) that minimizes damper friction and king pin moment is typically determined by Statics/Kinematics calculations. There is not a device available on the open market today which can mimic the coil spring reaction force vector within the suspension system.</div><div class="htmlview paragraph">Such a programmable coil spring reaction force vector generator, named “Universal Spring”, was developed in 2003 (USPG2003), and was then improved in 2013 (USPG2013) from the standpoint of accuracy, durability and reliability. The device is actuated by six hydraulic cylinders constructing a Stewart platform type parallel mechanism. Accuracy of FLP generated by USPG2013 is 1.1mm at maximum in ϕ80mm area around strut axis. Using this modified device, the relationship between the spring reaction force vector and damper friction, as well as spring reaction force vector and king pin moment, can be experimentally studied to confirm vehicle characteristics without actually producing any prototype coil springs. These studies will be discussed in this paper with showing actual measured data. Furthermore, it was found that approximately 70% of moment generated by upper bearing friction was transferred to king pin moment for the suspension system used in this experiment. The validity of this device was proven by comparing to actual coil spring based testing data.</div></div>
Synthesen von Cholinphosphatiden, III. Über die Synthese von Lysolecithinen und ihren Ätheranaloga (1967)

Abstract Durch hydrogenolytische Abspaltung der Benzylgruppe aus acyl‐ bzw. alkylsubstituierten Glycerin‐benzyläther‐(1)‐ bzw. ‐(2)‐phosphorsäure‐(3)‐cholinestern ( 10 ) wurden analysenreine und dünnschichtchromatographisch einheitliche Racemate von Ester‐( 2ab ) und Äther‐Lysolecithinen ( 2c, 4 ) erhalten. Die Acylverbindungen erwiesen sich in bezug auf R F ‐Wert und Infrarotspektrum als identisch mit enzymatisch aus Lecithin ex ovo erhaltenem L ‐Lysolecithin.
Selection and improvement of wine yeasts (2000)

Abstract- The selection of wine yeasts is usually carried out within the species Saccha-romyces cerevisiae. It aims at identifying the yeast strains that, besides fermenting grape juice vigorously and producing high ethanol yield, can also positively influence the com-position and the sensorial characteristics of wine. The natural availability of yeast strains possessing an ideal combination of oenological characteristics is highly improbable. Moreover, selected S. cerevisiae wine strains usually produce wines with a plain aromatic profile. The extension of the selection of wine yeasts to S. cerevisiae not growing in oeno-logical environments or to non-Saccharomyces yeasts has provided strains possessing novel and interesting oenological characteristics. Nevertheless, these strains cannot be directly used as starter cultures in wine fermentations, mainly because they are not vigo-rous or competitive in oenological conditions. Wine strains possessing innovative oenolo-gical traits that can influence the sensorial characteristics of wine can be constructed using genetic or molecular methods. Intraspecific S. cerevisiae hybridisation has provided useful oenological strains. Nevertheless, the traits of oenological interest that can be exchanged or introduced using this technique are only those commonly found in the species S. cerevisiae.
Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis. (1995)

Imbalance in the network of soluble mediators may play a pivotal role in the pathogenesis of Kaposi's sarcoma (KS). In this study, we demonstrated that KS cells grown in vitro produced and in part released platelet activating factor (PAF), a powerful lipid mediator of inflammation and cell-to-cell communication. IL-1, TNF, and thrombin enhanced the synthesis of PAF. PAF receptor mRNA and specific, high affinity binding site for PAF were present in KS cells. Nanomolar concentration of PAF stimulated the chemotaxis and chemokinesis of KS cells, endothelial cells, and vascular smooth muscle cells. The migration response to PAF was inhibited by WEB 2170, a hetrazepinoic PAF receptor antagonist. Because neoangiogenesis is essential for the growth and progression of KS and since PAF can activate vascular endothelial cells, we examined the potential role of PAF as an instrumental mediator of angiogenesis associated with KS. Conditioned medium (CM) from KS cells (KS-CM) or KS cells themselves induced angiogenesis and macrophage recruitment in a murine model in which Matrigel was injected subcutaneously. These effects were inhibited by treating mice with WEB 2170. Synthetic PAF or natural PAF extracted from plasma of patients with classical KS also induced angiogenesis, which in turn was inhibited by WEB 2170. The action of PAF was amplified by expression of other angiogenic factors and chemokines: these included basic and acidic fibroblast growth factor, placental growth factor, vascular endothelial growth factor and its specific receptor flk-1, hepatocyte growth factor, KC, and macrophage inflammatory protein-2. Treatment with WEB 2170 abolished the expression of the transcripts of these molecules within Matrigel containing KS-CM. These results indicate that PAF may cooperate with other angiogenic molecules and chemokines in inducing vascular development in KS.