gebhart/patrepeval huggingface dataset:
Immunohistochemical Localization of Tenascin, Estrogen Receptor and Transforming Growth Factory-&beta;<sub>1</sub> in Human Endometrial Carcinoma (1996)

Tenascin is an extracellular matrix glycoprotein which plays a role in cell attachment, proliferation and migration. To elucidate the function of tenascin in the proliferation of endometrial carcinoma, we studied tenascin expression in the endometrial carcinoma of 36 cases. In 22 of the carcinomas, tenascin expression was intense in the entire extracellular space, especially at the front of muscle invasion. Furthermore, in cases with metastases, deep invasion into muscles and vascular invasion, the rate of tenascin expression was significantly high. Immunoelectron microscopy revealed the tenascin reaction product in the stroma around fibroblasts located some distance from the basal lamina of cancer cells. On the other hand, tenascin expression was found in a high proportion of cases showing weak or no expression of estrogen receptor, and intense expression of transforming growth factor-beta 1. These results suggest that tenascin not only promotes cell proliferation and invasion but also inhibits further proliferation of carcinoma.
The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing (2000)

Lymphoid Enhancer Factor-1 (LEF-1) is a member of a family of transcription factors that function as downstream mediators of the Wnt signal transduction pathway. In the absence of Wnt signals, specific LEF/TCF isoforms repress rather than activate gene targets through recruitment of the co-repressor CtBP. Characterization of the full-length human LEF-1 gene locus and its complete set of mRNA products shows that this family member exists as a unique set of alternatively spliced isoforms; none are homologous to TCF-1E/TCF-4E. Therefore LEF-1 is distinct from its TCF family members in that it cannot engage in activities specific to this isoform such as recruitment of the co-repressor CtBP. Expression of alternatively spliced LEF-1 isoforms are driven by a promoter that is highly active in lymphocyte cell lines. Transcription initiates within a TATA-less core promoter region that contains consensus binding sites for Sp1, an E box, an Initiator element and a LEF/TCF binding site, all juxtaposed to the start sites of transcription. The promoter is most active in a B lymphocyte cell line (Raji) in which the endogenous LEF-1 gene is silent, suggesting that the promoter region is actively repressed by a silencing mechanism.
Numerical Analysis of Perforated Tube Muffler (2008)

To reduce the complexity of the model of perforated tube muffler,in this paper the MECHEL formula is applied to the model by imposing impedance boundary condition.The predicted transmission loss of the muffler using the finite element method and the result obtained by J.M.Sullian and M.J.Crocker(predicted and measured) are compared and showed good agreement.The comparison of the feature of transmission loss of the muffler with the same diameter and different porosity is carried out.The resuft certifies the feasibility of the method.
Stand-by/active mode logic for sub-1 V 1 G/4 Gb DRAMs (1993)

A new stand-by/active mode Logic I,II has been developed for the future 1G/4Gb DRAMs. The proposed Logic I, II can achieve sub-1V supply voltage operation with small l /spl mu/A subthreshold leakage current during stand-by cycle, by allowance of 1 mA transistor leakage current during the active cycle. The gate delay of Logic I is reduced by 37%-30% with the optimized channel widths for Vcc=O.8-1.5 V, as compared with that of the conventional logic. The gate delay of Logic II is also reduced by 85%-40% as compared with that of the conventional logic at Vcc=0.8-1.5 V. The proposed Logic I.II are easily applicable not only to 1G/4Gb DRAMs but also other types of memories such as SRAM and battery-operated memories.
Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers (2000)

In a randomized, placebo-controlled, double-blinded trial with 12 healthy volunteers, we studied the interaction of morphine and gabapentin using the cold pressor test. The anticonvulsant gabapentin enhanced the acute analgesic effect of morphine. Furthermore, the plasma concentration of gabapentin was increased when morphine was administered concomitantly. Therefore, the well tolerated combination of gabapentin and morphine may improve pain therapy, especially in pain states, like chronic and neuropathic pain, which respond poorly to opioids.
Liquid anti-contamination systems for hybrid laminar flow control aircraft—a review of the critical issues and important experimental results (2004)

Contamination of the aircraft leading edges by insects and other airborne particles is a major operational concern for the implementation of hybrid laminar flow control (HLFC)-an active drag reduction technique, which has the potential to produce significant fuel savings for airliners. A review of the critical issues is provided, encompassing the transition mechanism, insect distributions and concepts for contamination mitigation. The use of liquid/foam-based systems has proved to be very successful, as is evident in the review of experimental work.
Synthesis and characterization of Bi<sub>2</sub>O<sub>3</sub>/HSA core‐shell nanoparticles for X‐ray imaging applications (2012)

Bismuth oxide nanoparticles of 12.1 ± 3.0 nm diameter were prepared by thermal decomposition of bismuth acetate dissolved in ethylene glycol in the presence of an oxidizing agent. Functionalization and stabilization of the hydrophobic Bi(2)O(3) nanoparticles was accomplished by coating these core nanoparticles with human serum albumin (HSA), via a precipitation process. The formed Bi(2)O(3)/HSA core-shell nanoparticles were of 15.2 ± 3.5 nm diameter. Elemental analysis measurements indicated that the bismuth weight % of the Bi(2)O(3)/HSA core-shell nanoparticles is 72.9. The crystalline structure of these nanoparticles was examined by XRD. The radiopacity of these nanoparticles was demonstrated in vitro and in vivo by a CT scanner. In ovo and in vivo trials proved the safety of these Bi(2)O(3)/HSA core-shell nanoparticles. In the future, we plan to extend this study particularly for molecular imaging applications.
Xenopus Y-box transcription factors: molecular cloning, functional analysis and developmental regulation. (1990)

We describe the cloning and characterization of two cDNAs from Xenopus laevis that encode sequence-specific DNA binding proteins called FRG Y1 and FRG Y2 (frog Y-box proteins 1 and 2). During oogenesis and embryogenesis, the genes encoding these proteins are differentially expressed. FRG Y1 mRNA is present in oocytes, embryos, and all adult tissues examined, whereas FRG Y2 mRNA is found only in testis and immature oocytes. The FRG Y1 and FRG Y2 proteins are shown to stimulate transcription from a promoter containing a Y box (CTGATTGGCCAA). This promoter element is found in both mammalian major histocompatibility complex class II and Xenopus germ-cell-specific genes. FRG Y1, FRG Y2, and a human Y-box binding protein are homologous and represent a distinct family of sequence-specific DNA binding proteins. We identify protamine-like regions that are present within this family of transcription factors, suggesting that they use unusual means of binding to DNA.
Use of hyperspectral imaging to distinguish normal, precancerous, and cancerous cells (2008)

HSI can be utilized in prescreening liquid-based Pap test slides to improve efficiency in Pap test diagnoses with the goal of ultimately reducing the mortality from cervical cancer while reducing health care costs.
Second-generation PVCC design with a dielectric light injector and polyhedron interior cavity (2006)

The Photovoltaic Cavity Converter (PVCC) under development is a novel approach to convert highly concentrated solar radiation into electricity via a photon entrapment process and subsequent spectral stripping. Equipped with a multi-bandgap, single junction cell system PVCC circumvents most of the present limitations of the four (or more)-junction cell systems with vertical architecture. Our previous studies have shown that the PVCC concept has the potential to reach a collective conversion efficiency of 50% in the near term. Based on our past experiences regarding the cavity geometry and the light injection method we have developed a second generation design for the PVCC that overcomes the limitations of the first generation prototype.
Precision Medicine for Critical Illness and Injury (2016)

Buchman, Timothy G. PhD, MD, MCCM; Billiar, Timothy R. MD; Elster, Eric MD; Kirk, Allan D. MD; Rimawi, Ramzy H. MD; Vodovotz, Yoram PhD; Zehnbauer, Barbara A. PhD Author Information
Brands across borders: Determining factors in choosing franchising or management contracts for entering international markets (2002)

Should hotel companies expand internationally through management contracts or franchising?It depends on a company's core competencies-as well as the resources available in the market itself. Contractual arrangements such as franchises and management contracts have long been popular means by which hotel companies enter international markets. 1 This study examines the factors that hotels consider in making the choice between expanding via franchises or with management contracts.The study takes into consideration a firm's resources and skills, as well as some environmental factors that influence this choice.
Maximum SNR pattern strategy for phase shifting methods in structured light illumination (2010)

Structured light illumination by means of phase shifting patterns is a widely employed method for three-dimensional (3-D) image acquisition that is robust to ambient light and object albedo but may be especially susceptible to sensor and environment noise. In this paper, we study the specific technique of phase measuring profilometry (PMP) and the maximization of a pattern's signal to noise ratio (SNR). By treating the design of an N-pattern PMP process as placing points in an N-dimensional coding space, we define a pattern's SNR in terms of a pattern set's computational length and the number of coded phase periods in the projected patterns. Then, without introducing phase ambiguities, we propose a so-called edge pattern strategy that maximizes the computational length and number of periods. Theoretically, the edge pattern technique improves the SNR by 1.2381 times when using three component patterns and by 15.5421 times when using five patterns. Experimental results further demonstrate the improved SNR of the proposed edge pattern technique such that more accurate 3-D results are achieved using fewer component patterns.
Hydrogen plasma effects on ultralow-k porous SiCOH dielectrics (2005)

This study investigated the interactions of hydrogen plasmas with ultralow-k porous SiCOH (pSiCOH) films and their dependency on the values of the original dielectric constant, porogen used for the preparation of films, and substrate temperature during the plasma treatment. pSiCOH films of similar dielectric constants have been prepared by plasma-enhanced chemical-vapor deposition using an identical SiCOH skeleton precursor, but with two different organic porogens. The films exposed to the hydrogen plasmas have been characterized by optical techniques, shrinkage characterization, and electrical measurements. It was found that the hydrogen plasma modifies the structure of pSiCOH’s oxide skeleton and reduces the concentration of the Si–(CH3)1 bonds, resulting in an increase of the dielectric constant. The degree of modification, for films prepared from the same precursors, is larger for films with lower dielectric constants (k) and is affected by the porogen used to prepare films with similar k values.
From Self-Assembled Vesicles to Protocells (2010)

Self-assembled vesicles are essential components of primitive cells. We review the importance of vesicles during the origins of life, fundamental thermodynamics and kinetics of self-assembly, and experimental models of simple vesicles, focusing on prebiotically plausible fatty acids and their derivatives. We review recent work on interactions of simple vesicles with RNA and other studies of the transition from vesicles to protocells. Finally we discuss current challenges in understanding the biophysics of protocells, as well as conceptual questions in information transmission and self-replication.
From datalog rules to efficient programs with time and space guarantees (2009)

This article describes a method for transforming any given set of Datalog rules into an efficient specialized implementation with guaranteed worst-case time and space complexities, and for computing the complexities from the rules. The running time is optimal in the sense that only useful combinations of facts that lead to all hypotheses of a rule being simultaneously true are considered, and each such combination is considered exactly once in constant time. The associated space usage may sometimes be reduced using scheduling optimizations to eliminate some summands in the space usage formula. The transformation is based on a general method for algorithm design that exploits fixed-point computation, incremental maintenance of invariants, and combinations of indexed and linked data structures. We apply the method to a number of analysis problems, some with improved algorithm complexities and all with greatly improved algorithm understanding and greatly simplified complexity analysis.
The interaction of IgG with FcγRII: Involvement of the lower hinge binding site as probed by NMR (1993)

Conference Article| November 01 1993 The interaction of IgG with FcγRII: Involvement of the lower hinge binding site as probed by NMR SIOBHAN A. HINDLEY; SIOBHAN A. HINDLEY 1Immunology Dept., Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT Search for other works by this author on: This Site PubMed Google Scholar YUAN GAO; YUAN GAO 1Immunology Dept., Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT Search for other works by this author on: This Site PubMed Google Scholar PETER H. NASH; PETER H. NASH 1Immunology Dept., Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT Search for other works by this author on: This Site PubMed Google Scholar CATHERINE SAUTES; CATHERINE SAUTES *INSERM U.255, Institut Curie, 26 rue d'ULM, 75251 Paris, Cedex 05, France Search for other works by this author on: This Site PubMed Google Scholar JOHN LUND; JOHN LUND 1Immunology Dept., Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT Search for other works by this author on: This Site PubMed Google Scholar MARGARET GOODALL; MARGARET GOODALL 1Immunology Dept., Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT Search for other works by this author on: This Site PubMed Google Scholar ROYSTON JEFFERIS ROYSTON JEFFERIS 1Immunology Dept., Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1993) 21 (4): 337S. https://doi.org/10.1042/bst021337s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation SIOBHAN A. HINDLEY, YUAN GAO, PETER H. NASH, CATHERINE SAUTES, JOHN LUND, MARGARET GOODALL, ROYSTON JEFFERIS; The interaction of IgG with FcγRII: Involvement of the lower hinge binding site as probed by NMR. Biochem Soc Trans 1 November 1993; 21 (4): 337S. doi: https://doi.org/10.1042/bst021337s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1993 Biochemical Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
Periparturient Traits in Seven High Dairy Herds. Incidence Rates, Association with Parity, and Interrelationships Among Traits (1987)

Interrelationships among nine periparturient traits and their association with parity were investigated in 8521 calvings of dairy cows examined routinely between 5 to 14 d postpartum. Rates of twins, stillbirth, milk fever, prolapsed uterus, retained placenta, primary metritis, displaced abomasum, ketonuria, and aciduria were 5.8, 6.3, 1.4, 3, 17.8, 36.1, 1.7, 30.4, and 29.5%, respectively. The risk for twins, milk fever, prolapsed uterus, displaced abomasum, ketonuria, and aciduria increased with parity, whereas that for stillbirth and metritis was higher in heifers than in cows. Stillbirth, retained placenta, metritis, displaced abomasum, ketonuria, and aciduria were directly associated with birth of twins; prolapsed uterus and retained placenta with stillbirth; prolapsed uterus, retained placenta, and primary metritis with milk fever; displaced abomasum, ketonuria, and aciduria with retained placenta and with metritis; ketonuria and aciduria with displaced abomasum and aciduria with ketonuria.
Angiotensin II in the Brain and Pituitary: Contrasting Roles in the Regulation of Adenohypophyseal Secretion (1989)

Angiotensin II (AII) is present in gonadotropes in rats, and there are AII receptors on lactotropes and corticotropes. AII may be a paracrine mediator that stimulates the secretion of prolactin and adrenocorticotropin (ACTH) at the level of the pituitary, but additional research is needed to define its exact role. Angiotensinogen may also reach the gonadotropes via a paracrine route. On the other hand, there is considerable evidence that brain AII stimulates the secretion of luteinizing hormone (LH) by increasing the secretion of LH-releasing hormone, and that this effect is due to AII-mediated release of norepinephrine from noradrenergic nerve terminals in the preoptic region of the hypothalamus. In addition, brain AII inhibits the secretion of prolactin, probably by increasing the release of dopamine into the portal hypophyseal vessels. Circulating AII stimulates the secretion of a third anterior pituitary hormone, ACTH, by acting on one or more of the circumventricular organs to increase the secretion of corticotropin-releasing hormone.
Characterization of Reentrant Circuits in Left Atrial Macroreentrant Tachycardia (2002)

The reentry circuit with a protected isthmus can be identified in 89% patients with LAMRT by electroanatomic mapping. The isthmuses were amenable to radiofrequency applications in most patients. No atrial tachycardia recurred in any patients with isthmus block.
<i>btn1 </i>Affects Endocytosis, Polarization of Sterol‐Rich Membrane Domains and Polarized Growth in<i> Schizosaccharomyces pombe</i> (2008)

btn1, the Schizosaccharomyces pombe orthologue of the human Batten disease gene CLN3, exerts multiple cellular effects. As well as a role in vacuole pH homoeostasis, we now show that Btn1p is essential for growth at high temperatures. Its absence results in progressive defects at 37 degrees C that culminate in total depolarized growth and cell lysis. These defects are preceded by a progressive failure to correctly polarize sterol-rich domains after cytokinesis and are accompanied by loss of Myo1p localization. Furthermore, we found that in Sz. pombe, sterol spreading is linked to defective formation/polarization of F-actin patches and disruption of endocytosis and that these processes are aberrant in btn1Delta cells. Consistent with a role for Btn1p in polarized growth, Btn1p has an altered location at 37 degrees C and is retained in actin-dependent endomembrane structures near the cell poles or septum.
Transcriptomic profiling facilitates classification of response to influenza challenge (2014)

Differential gene expression signatures are seen following influenza challenge. Expression of six predictive genes can classify response to influenza challenge. The genomic influenza response classification replicates in an independent dataset.
Spectral hole-burning spectroscopy in amorphous molecular solids and proteins (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectral hole-burning spectroscopy in amorphous molecular solids and proteinsR. Jankowiak, J. M. Hayes, and G. J. SmallCite this: Chem. Rev. 1993, 93, 4, 1471–1502Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/cr00020a005https://doi.org/10.1021/cr00020a005research-articleACS PublicationsRequest reuse permissionsArticle Views669Altmetric-Citations217LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bullet (2003)

In recent years, overlay networks have become an effective alternative to IP multicast for efficient point to multipoint communication across the Internet. Typically, nodes self-organize with the goal of forming an efficient overlay tree, one that meets performance targets without placing undue burden on the underlying network. In this paper, we target high-bandwidth data distribution from a single source to a large number of receivers. Applications include large-file transfers and real-time multimedia streaming. For these applications, we argue that an overlay mesh , rather than a tree, can deliver fundamentally higher bandwidth and reliability relative to typical tree structures. This paper presents Bullet , a scalable and distributed algorithm that enables nodes spread across the Internet to self-organize into a high bandwidth overlay mesh. We construct Bullet around the insight that data should be distributed in a disjoint manner to strategic points in the network. Individual Bullet receivers are then responsible for locating and retrieving the data from multiple points in parallel.Key contributions of this work include: i) an algorithm that sends data to different points in the overlay such that any data object is equally likely to appear at any node, ii) a scalable and decentralized algorithm that allows nodes to locate and recover missing data items, and iii) a complete implementation and evaluation of Bullet running across the Internet and in a large-scale emulation environment reveals up to a factor two bandwidth improvements under a variety of circumstances. In addition, we find that, relative to tree-based solutions, Bullet reduces the need to perform expensive bandwidth probing. In a tree, it is critical that a node's parent delivers a high rate of application data to each child. In Bullet however, nodes simultaneously receive data from multiple sources in parallel, making it less important to locate any single source capable of sustaining a high transmission rate.