gebhart/patrepeval huggingface dataset:
Substrate Modulation of Morphology, Growth, and Tear Protein Production by Cultured Human Lacrimal Gland Epithelial Cells (1995)

Human lacrimal gland biopsies were serially incubated in chelating and enzymatic solutions. Viable single cells were evaluated for outgrowth in growth factor enriched medium using the following culture substrates: Matrigel, Type I collagen gel with or without fibroblasts, and plastic. Each epithelial outgrowth was characterized morphologically and immunohistochemically, and their growth and viability were examined by BrdU labeling and a quantitative cell viability assay. Synthesized proteins were evaluated by ELISA, SDS-PAGE, and 14C-labeled amino acid incorporation. Lacrimal gland epithelial cells plated on Matrigel formed clusters with central cavities that contained lactoferrin, mimicking acinar complexes in vivo. Cells plated on collagen gel or collagen gel containing fibroblasts formed islands or a monolayer, and lactoferrin was detected in incomplete cavities of epithelia on the latter substrate. Epithelial cells plated on plastic formed a monolayer and cellular expression of lactoferrin was weak and sporadic. Cellular release of the lactoferrin measured by ELISA supported the results of immunohistochemistry. Cells grown on plastic had the highest proliferative rate, whereas those grown on Matrigel showed the lowest proliferative rate. These results indicate that different substrates modulate lacrimal gland epithelial cell morphology, proliferative rate, and production of the tear protein lactoferrin. Matrigel promotes acinar differentiation to a greater extent than collagen gel and plastic. Incorporation of fibroblasts in collagen gel substrate promotes significant effects on growth and differentiation.
Morphology of Zirconia Synthesized Hydrothermally from Zirconium Oxychloride (1992)

Monoclinic zirconia has been synthesized hydrothermally from zirconium oxychloride in the range 20–100 MPa, 250–650°C, for run duration from 20 to 100 h and in the presence of NaOH, Na 2 CO 3 , Na 2 SO 4 , NH 4 F, HNO 3 , and H 2 SO 4 additives. Isometric, platelike, and elongated crystal morphologies were obtained depending on the additive. Both spherulitic and isolated textures were encountered with H 2 SO 4 . Growth of isometric crystals follows a general dissolution–precipitation mechanism. For H 2 SO 4 , two growth steps were identified: an early spherulitic step followed by an isolated crystals step resulting from Ostwald ripening of preexisting spherulites. The formation of spherulites is consistent with the specific properties of the sulfuric hydrothermal medium.
[Intraorganic blood vessels of the intestinal graft after its ortho- and heterotopic transplantation]. (1989)

In experiments, performed on 85 dogs of both sex ortho- and heterotopic total autotransplantation of the small intestine and extracorporal connection of the allogenic segments of the small intestine have been carried out. Certain dependency of morphological changes of the intraorganic blood bed on the operation model has been stated. Essential changes in the blood bed at the heterotopic autotransplantation depend on inadequate regional hemodynamics in the graft. Therefore, the heterotopic model should be considered less preferable than the orthotopic one. One of the peculiarities in reconstruction of the intraorganic vascular bed after ortho- and heterotropic transplantation of the small intestine is, evidently, opening of lympho-venular anastomoses.
<i>MDP1</i>, a <i>Saccharomyces cerevisiae</i> Gene Involved in Mitochondrial/Cytoplasmic Protein Distribution, Is Identical to the Ubiquitin-Protein Ligase Gene <i>RSP5</i> (1997)

Alteration of the subcellular distribution of Mod5p-I, a tRNA modification enzyme, member of the sorting isozyme family, affects tRNA-mediated nonsense suppression. Altered suppression efficiency was used to identify MDP genes, which, when mutant, change the mitochondrial/cytosolic distribution of Mod5p-I,KR6. MDP2 is the previously identified VRP1, which encodes verprolin, required for proper organization of the actin cytoskeleton. MDP3 is identical to PAN1, which encodes a protein involved in initiation of translation and actin cytoskeleton organization. We report here the cloning and characterization of wild-type and mutant MDP1 alleles and the isolation and characterization of a multicopy suppressor of mdp1 mutations. MDP1 is identical to RSP5, which encodes ubiquitin-protein ligase, and mdp1 mutations are suppressed by high copy expression of ubiquitin. All four characterized mdp1 mutations cause missense changes located in the hect domain of Rsp5p that is highly conserved among ubiquitin-protein ligases. In addition to its well-known function in protein turnover, ubiquitination has been proposed to play roles in subcellular sorting of proteins via endocytosis and in delivery of proteins to peroxisomes, the endoplasmic reticulum and mitochondria. mdp1, as well as mdp2/vrp1 and mdp3/pan1 mutations, affect endocytosis. Further, mdp1 mutations show synthetic interactions with mdp2/vrp1 and mdp3/pan1. Identification of MDP1 as RSP5, along with our previous identification of MDP2/VRP1 and MDP3/PAN1, implicate interactions of the ubiquitin system, the actin cytoskeleton and protein synthesis in the subcellular distribution of proteins.
Extraction of organics from aqueous solutions using critical-fluid carbon dioxide (1982)

The recovery of ethanol from ethanol-water solutions by solvent extraction with liquid or supercritical carbon dioxide is described. Early results indicate that the process has the potential to significantly reduce the energy requirement for the separation. Pilot-plant studies were carried out using fermentation broths and synthetic ethanol solutions. 6 figures, 7 tables.
High density microwave packaging program phase 1-Texas Instruments/Martin Marietta team (2002)

On the ARPA sponsored High Density Microwave Packaging (HDMP) program, a team composed of Texas Instruments (TI), Martin Marietta, and General Electric (GE) is developing a packaging system to support tile conformal phased arrays. Significant volume and weight reductions are projected relative to today's microwave module technology. The team's approach utilizes a stacked module configuration, with a surface contact vertical interconnect between module layers. The module layers are built on a metal matrix composite AlSiC substrate with silicon and MMIC devices mounted face-up in substrate wells. Chip-to-chip interconnect is provided by an enhanced version of Martin Marietta's Microwave High Density Interconnect (MHDI) process. Stacked module assemblies are surface mounted on an RF/DC manifold on the back of the conformal array surface. Incremental technology demonstrations are planned as part of the program, culminating in a 96-element brassboard array demonstration.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Is the Readmission Rate a Valid Quality Indicator? A Review of the Evidence (2014)

Although readmission rates are a promising quality indicator, several methodological concerns identified in this study need to be addressed, especially when the indicator is intended for accountability or pay for performance. We recommend investing resources in accurate data registration, improved indicator description, and bundling outcome measures to provide a more complete picture of hospital care.
Functional analysis of the promoters of the human red and green visual pigment genes. (1998)

The WERI cell line is a good model system for the analysis of gene expression of the human cone visual pigment genes. The expression of these genes in a cell-specific fashion seems to be controlled mainly by positive-acting elements in the region between - 130 and the TATA box. The higher activity of the green pigment gene promoter could have evolved to compensate for its longer distance from the activating LCR than that of the red pigment gene promoter (approximately 34 versus 3.5 kb). Although the LCR does not enhance transcription in transient transfection, it binds factors that also recognize the proximal promoter region. These interactions may be important for the establishment of a transcriptionally active domain in a chromatin context.
Current gain collapse in microwave multifinger heterojunction bipolar transistors operated at very high power densities (1993)

The rapid development of heterojunction bipolar transistor (HBT) technologies has led to the demonstration of high power single-chip microwave amplifiers. Because HBTs are operated at high power densities, the ultimate limits on the performance of HBTs are imposed by thermal considerations. The authors address a thermal phenomenon observed when a multifinger power HBT is operating at high power densities. This phenomenon, referred to as the collapse (of current gain), occurs when suddenly one finger of the HBT draws most of the collector current, leading to an abrupt decrease of current gain. A quantitative model and the condition separating the normal operation region and the collapse are presented. Critical difference of the collapse in the constant l/sub b/ and constant V/sub be/ modes of operation is discussed for the common-emitter l-V characteristics. The collapse in the common-base l-V characteristics and its relationship with avalanche breakdown are also described. A solution to eliminate the collapse is experimentally verified.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Resource allocation for LTE-direct broadcast of periodic vehicular safety messages (2013)

Direct Device-to-Device (D2D) communications underlaying the cellular network are receiving increasing attention lately: LTE-A standard will adopt them for unicast proximity services. So far, no application has been envisioned for broadcast transmissions. In this work, we propose an eMBMSinspired mechanism to allocate a quasi-static pool of resources over multiple eNodeBs (eNBs) for D2D broadcast transmissions to take place. The mechanism does neither require any connection procedure with the eNB nor any additional network-side mobility management. Further, we propose multiple access according to a distributed TDMA-like scheme. We apply this concept to the periodic broadcast of CAMs / BSMs and show that the system's flexibility and extensibility make LTE-Direct a good complementary technology to DSRC for periodic vehicular safety communications.
Monitoring of inter-area oscillations under ambient conditions using subspace identification (2009)

The damping of inter-area oscillations is a major concern for many power system operators. This paper presents a novel method for monitoring of inter-area oscillations based on system identification using subspace techniques and modal analysis. The method enables the detection of oscillatory modes as well as the damping and frequency of those from ambient data recorded during normal operation of the power system. Through modal observability which is also estimated, the parts of the grid participating in an oscillation mode can be determined. The method is suitable for real-time implementation. The paper demonstrates application of the method to measurements from the Nordic power system and to synthetic data. The technique can be used to increase operator situational awareness and provide early warning in case of potential for unstable inter-area mode oscillations.
Evidence for mutation being the source of the abnormal gene for plasma cholinesterase (1974)

Results of cholinesterase, dibucaine and fluoride numbers, and scoline hydrolysis rates are presented in a family found to have normal, silent and abnormal genes for plasma cholinesterase. Five sibs, confirmed by red cell grouping and tissue typing, have been shown to possess a cholinesterase pattern which cannot be explained on the basis of accepted theories of inheritance. In view of this it is suggested that, in this family, a mutation has occurred from a normal or silent gene to an abnormal gene.
Melker van Morgen Award 2003 naar gezinsbedrijf Mensink (2003)

De jury oordeelde dat het bedrijf zich onder andere onderscheidt doordat het qua mineralenmanagement z'n tijd ver vooruit is geweest.
A Security Analysis and Revised Security Extension for the Precision Time Protocol (2016)

The Precision Time Protocol (PTP) aims to provide highly accurate and synchronized clocks. Its defining standard, IEEE 1588, has a security section (“Annex K”) which relies on symmetric-key secrecy. In this paper we present a detailed threat analysis of the PTP standard, in which we highlight the security properties that should be addressed by any security extension. During this analysis we identify a sequence of new attacks and non-cryptographic network-based defenses that mitigate them. We then suggest to replace Annex K's symmetric cryptography by an efficient elliptic-curve Public-Key signatures. We implemented all our attacks to demonstrate their effectiveness, and also implemented and evaluated both the network and cryptographic defenses. Our results show that the proposed schemes are extremely practical, and much more secure than previous suggestions.
Zirconium(IV) Chloride–Mediated Chemoselective Conjugate Addition of Aliphatic Amines to α,β‐Ethylenic Compounds (2006)

Abstract Zirconium chloride efficiently catalyzes the conjugate addition of a variety of aliphatic amines to α,β‐unsaturated ester, nitriles, and ketones to give the corresponding β‐amino derivatives in excellent yields under mild reaction conditions. Aromatic amines do not participate in this transformation.
Tuning surface plasmon-exciton coupling via thickness dependent plasmon damping (2012)

In this paper, we report experimental and theoretical investigations on tuning of the surface plasmon-exciton coupling by controlling the plasmonic mode damping, which is defined by the plasmonic layer thickness. The results reveal the formation of plasmon-exciton hybrid state characterized by a tunable Rabi splitting with energies ranging from 0 to 150 meV. Polarization-dependent spectroscopic reflection measurements were employed to probe the dispersion of the coupled system. The transfer matrix method and analytical calculations were used to model the self-assembled $J$-aggregate/metal multilayer structures in excellent agreement with experimental observations.
Verification and validation: some approaches and paradigms for verifying and validating simulation models (2001)

In this paper we discuss verification and validation of simulation models. The different approaches to deciding model validity are described, two different paradigms that relate verification and validation to the model development process are presented, the use of graphical data statistical references for operational validity is discussed, and a recommended procedure for model validation is given.
InP heterojunction bipolar transistor with a selectively implanted collector pedestal (2004)

In a mesa structured HBT, a large portion of C/sub bc/originates from the extrinsic base-collector region under the base contact. To reduce extrinsic C/sub bc/, an HBT structure with a selectively implanted collector pedestal and MBE growth, under the HBT intrinsic region is reported. The fabrication steps of the device are implant window and Si ion implant, implant mask removal and HT annealing, HBT structure regrowth and triple-mesa HBT fabrication. The results exhibit low I/sub cbo/ and hence high junction quality can be obtained in a collector pedestal process incorporating regrowth.
Overlay Communications Using Empirical Mode Decomposition (2010)

A signal overlay technique employing the empirical mode decomposition procedure is presented here. A weak narrowband signal is added to the primary signal that shares the same frequency band. Careful signal design reduces interference caused to primary users while ensuring successful recovery of the added signal. At the receiver a stationary filtering approach is ineffective in separating the signals because a fixed filter designed to isolate one of the signals will also capture significant portion of the other signal energy due to overlapping spectrums. However, the empirical mode decomposition technique, that isolates signal components based on their instantaneous frequencies, is ideally suited to separate these time-varying signals with overlapping frequency components. The choice of overlay signal transmission frequencies relative to that of the primary signal is made in such a way that leads to greater resemblance of one of the extracted components to the original overlay signal. An application to commercial frequency modulation overlay is presented with associated analysis and empirical performance results.
Neural networks as on-line approximators of nonlinear systems (2005)

The authors present an approximation theory perspective in the design and analysis of nonlinear system identification schemes using neural network and other online approximation models. The identification procedure considered is based on a discrete-time formulation. Depending on the location of the adjustable parameters, networks are classified into linearly and nonlinearly parametrized networks. Based on this classification, a unified procedure for modeling discrete-time dynamical systems using online approximators is developed. The proposed identification methodology guarantees stability of the overall system even in the presence of modeling errors, and upper bounds for the average output error are obtained in terms of the modeling error. Simulation studies are used to illustrate the results and to compare different approximation models.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Single-board computer based control system for a portable Raman device with integrated chemical identification (2004)

We report the development of a battery-powered portable chemical identification device for field use consisting of an acousto-optic tunable filter (AOTF)-based Raman spectrometer with integrated data processing and analysis software. The various components and custom circuitry are integrated into a self-contained instrument by control software that runs on an embedded single-board computer (SBC), which communicates with the various instrument modules through a 48-line bidirectional TTL bus. The user interacts with the instrument via a touch-sensitive liquid crystal display unit (LCD) that provides soft buttons for user control as well as visual feedback (e.g., spectral plots, stored data, instrument settings, etc.) from the instrument. The control software manages all operational aspects of the instrument with the exception of the power management module that is run by embedded firmware. The SBC-based software includes both automated and manual library searching capabilities, permitting rapid identification of samples in the field. The use of the SBC in tandem with the LCD touchscreen for interfacing and control provides the instrument with a great deal of flexibility as its function can be customized to specific users or tasks via software modifications alone. The instrument, as currently configured, can be operated as a research-grade Raman spectrometer for scientific applications and as a “black-box” chemical identification system for field use. The instrument can acquire 198-point spectra over a spectral range of 238–1620 cm−1, perform a library search, and display the results in less than 14 s. The operating modes of the instrument are demonstrated illustrating the utility and flexibility afforded the system by the SBC–LCD control module.
1 Gsymbol/s, 64 QAM coherent optical transmission over 150 km with a spectral efficiency of 3 bit/s/Hz (2007)

A 1 Gsymbol/s, 64 QAM coherent signal was successfully transmitted over 150 k m using heterodyne detection with a frequency-stabilized fiber laser and an optical phase-locked-loop technique. The spectral efficiency reached as high as 3 bit/s/Hz.
Learning principled bilingual mappings of word embeddings while preserving monolingual invariance (2016)

Mapping word embeddings of different languages into a single space has multiple applications. In order to map from a source space into a target space, a common approach is to learn a linear mapping that minimizes the distances between equivalences listed in a bilingual dictionary. In this paper, we propose a framework that generalizes previous work, provides an efficient exact method to learn the optimal linear transformation and yields the best bilingual results in translation induction while preserving monolingual performance in an analogy task.
Yeast-recombinant hepatitis B vaccine. Efficacy with hepatitis B immune globulin in prevention of perinatal hepatitis B virus transmission (1987)

A yeast-recombinant hepatitis B vaccine was licensed recently by the Food and Drug Administration and is now available. To assess the efficacy of the yeast-recombinant vaccine, we administered the vaccine in combination with hepatitis B immune globulin to high-risk newborns. If infants whose mothers were positive for both hepatitis B surface antigen and the e antigen receive no immunoprophylaxis, 70% to 90% become infected with the virus, and almost all become chronic carriers. Among infants in this study who received hepatitis B immune globulin at birth and three 5-micrograms doses of yeast-recombinant hepatitis B vaccine, only 4.8% became chronic carriers, a better than 90% level of protection and a rate that is comparable with that seen with immune globulin and plasma-derived hepatitis B vaccine. These data suggest that, in this high-risk setting, the yeast-recombinant vaccine is as effective as the plasma-derived vaccine in preventing hepatitis B virus infection and the chronic carrier state.
Natural‐product‐based chromenes as a novel class of potential termiticides (2011)

Chromene derivatives have been shown to be a potential novel class of termiticides against Formosan subterranean termites.
Skeletal myocytes are a source of interleukin‐6 mRNA expression and protein release during contraction: evidence of fiber type specificity (2004)

In this study, we aimed to determine whether skeletal muscle cells per se are a source of interleukin (IL)-6 during contraction and whether IL-6 production is fiber type specific. Muscle biopsy samples were collected from seven males before (PRE) and after (POST) completing 120 min of continuous bicycle ergometry. Biopsies were sectioned and analyzed for the following: IL-6 protein detected by immunohistochemistry (IHC), IL-6 mRNA content detected by in situ hybridization, fiber type measured by either IHC or myofibrillar ATPase activity stain, and glycogen content measured by periodic acid schiff (PAS) assay. Fibers were qualitatively categorized according to glycogen content to one of five groups (1-5), with 1 being very low (LOW) and 5 being very high (HIGH) glycogen. Total fluorescence (PRE vs. POST) and glycogen-dependent fluorescence (LOW vs. HIGH) of IL-6 protein were quantitated using Metamorph software. Total IL-6 protein was elevated from PRE to POST exercise (P<0.05). At PRE, IL-6 protein was evenly distributed across all fibers at low levels, consistent with glycogen distribution. At POST, IL-6 protein was greater (P<0.05) in HIGH compared with LOW glycogen fibers, which coincided with type 2 fibers. IL-6 mRNA was distributed peripherally in all fibers at PRE. At POST, however, IL-6 mRNA appeared predominantly in type 2 fibers, which also had higher glycogen content (P<0.05). These data demonstrate that myocytes per se are a source of IL-6 produced during contraction. Our data also suggest that type 2 fibers predominantly produce IL-6 during muscle contractile activity.