gebhart/patrepeval huggingface dataset:
Inhibition of epithelial cell adhesion by retinoic acid. Relationship to reduced extracellular matrix production and alterations in Ca2+ levels. (1991)

Human squamous epithelial cells maintained in growth factor-deficient medium were examined for sensitivity to all-trans retinoic acid (retinoic acid). Under conditions of low external Ca2+ (0.15 mmol/l [millimolar]), or high external Ca2+ (1.4 mmol/l), retinoic acid stimulated proliferation. Concomitantly, cell-substrate adhesion was decreased. Enzyme-linked immunosorbent assays were used to assess production of two extracellular matrix components, ie, fibronectin and thrombospondin. In the presence of retinoic acid, production of both was decreased. Because both fibronectin and thrombospondin serve as epithelial cell adhesion factors, the decreased production of these moieties could contribute to reduced adhesion. Using 45Ca2+ to measure total cell-associated Ca2+ and the Ca2(+)-sensitive dye Indo-1 to measure intracellular free Ca2+, it was found that concentrations of retinoic acid that altered cell-substrate adhesion in the squamous epithelial cells had no effect on total, cell-associated Ca2+, but reduced intracellular free Ca2+ by 50% to 60%. Because Ca2+ is a regulator of adhesion, the ability of retinoic acid to modulate Ca2+ levels in the squamous epithelial cells may explain, in part, how retinoic acid influences their adhesiveness.
<i>BAL1</i> and <i>BBAP</i> Are Regulated by a Gamma Interferon-Responsive Bidirectional Promoter and Are Overexpressed in Diffuse Large B-Cell Lymphomas with a Prominent Inflammatory Infiltrate (2006)

BAL1 is a transcription modulator that is overexpressed in chemoresistant, diffuse large B-cell lymphomas (DLBCLs). BAL1 complexes with a recently described DELTEX family member termed BBAP. Herein, we characterized BAL1 and BBAP expression in primary DLBCL subtypes defined by their comprehensive transcriptional profiles. BAL1 and BBAP were most abundant in lymphomas with a brisk host inflammatory response, designated host response (HR) tumors. Although these DLBCLs include significant numbers of tumor-infiltrating lymphocytes and interdigitating dendritic cells, BAL1 and BBAP were expressed primarily by malignant B cells, prompting speculation that the genes might be induced by host-derived inflammatory mediators such as gamma interferon (IFN-gamma). In fact, IFN-gamma induced BAL1 and BBAP expression in DLBCL cell lines; doxycycline-induced BAL1 also increased the expression of multiple IFN-stimulated genes, directly implicating BAL1 in an IFN signaling pathway. We show that BAL1 and BBAP are located on chromosome 3q21 in a head-to-head orientation and are regulated by a IFN-gamma-responsive bidirectional promoter. BBAP regulates the subcellular localization of BAL1 by a dynamic shuttling mechanism, highlighting the functional requirement for coordinated BBAP and BAL1 expression. IFN-gamma-induced BAL1/BBAP expression contributes to the molecular signature of HR DLBCLs and highlights the interplay between the inflammatory infiltrate and malignant B cells in these tumors.
Fluorescence Imaging Analysis of Upstream Regulators and Downstream Targets of STAT3 in Melanoma Precursor Lesions Obtained from Patients Before and After Systemic Low-Dose Interferon-α Treatment (2003)

Atypical nevi are the precursors and risk markers of melanoma. Apart from persistently monitoring these nevocytic lesions and resecting them at the earliest signs of clinical changes, there is as yet no systemic clinical treatment available to interfere with their progression to melanoma. To explore clinical treatments that might interfere with and possibly prevent atypical nevus progression, a previous study documented that 3 months systemic low-dose interferon-alpha (IFN-alpha) treatment of patients with a clinical history of melanoma and numerous atypical nevi, led to inactivation of the STAT1 and STAT3 transcription factors in atypical nevi. Based upon this finding, we initiated a second study to determine whether systemic low-dose IFN-alpha treatment also impairs the expression of upstream regulators and downstream targets of STAT1 and STAT3 in atypical nevi. Using cyanine dye-conjugated antibodies, fluorescence imaging analysis revealed expression of JAK2, JNK1, AKT1, NF-kappa B, and IFN-alpha/beta receptor in benign and atypical nevi, and early- and advanced-stage melanomas. To determine possible changes in the level of expression of these molecules in atypical nevi, excised before and after 3 months of systemic low-dose IFN-alpha treatment, newly designed optical imaging software was used to quantitate the captured fluorescent hybridization signals on a cell-by-cell basis and across an entire nevus section. The results of this analysis did not provide evidence that systemic low-dose IFN-alpha treatment alters the level of expression of upstream regulators or downstream targets of STAT1 and STAT3.
A Comparison of Progressive Loss of the Ellipsoid Zone (EZ) Band in Autosomal Dominant and X-Linked Retinitis Pigmentosa (2014)

The OCT data here support a faster rate of loss per year in the case of xlRP. (ClinicalTrials.gov number, NCT00100230.).
Molecular dynamics simulations of gas separations using faujasite-type zeolite membranes (2004)

Gas separations with faujasite zeolite membranes have been examined using the method of molecular dynamics. Two binary mixtures are investigated, oxygen/nitrogen and nitrogen/carbon dioxide. These mixtures have been found experimentally to exhibit contrasting behavior. In O(2)/N(2) mixtures the ideal selectivity (pure systems) is higher than the mixture selectivity, while in N(2)/CO(2) the mixture selectivity is higher than the ideal selectivity. One of the key goals of this work was to seek a fundamental molecular level understanding of such divergent behavior. Our simulation results (using previously developed intermolecular models for both the gases and zeolites investigated) were found to replicate this experimental behavior. By examining the loading of the membranes and the diffusion rates inside the zeolites, we have been able to explain such contrasting behavior of O(2)/N(2) and N(2)/CO(2) mixtures. In the case of O(2)/N(2) mixtures, the adsorption and loading of both O(2) and N(2) in the membrane are quite competitive, and thus the drop in the selectivity in the mixture is primarily the result of oxygen slowing the diffusion of nitrogen and nitrogen somewhat increasing the diffusion of oxygen when they pass through the zeolite pores. In N(2)/CO(2) systems, CO(2) is rather selectively adsorbed and loaded in the zeolite, leaving very little room for N(2) adsorption. Thus although N(2) continues to have a higher diffusion rate than CO(2) even in the mixture, there are so few N(2) molecules in the zeolite in mixtures that the selectivity of the mixture increases significantly compared to the ideal (pure system) values. We have also compared simulation results with hydrodynamic theories that classify the permeance of membranes to be either due to surface diffusion, viscous flow, or Knudsen diffusion. Our results show surface diffusion to be the dominant mode, except in the case of N(2)/CO(2) binary mixtures where Knudsen diffusion also makes a contribution to N(2) transport.
Some Recent Papers in the Journal of the Optical Society of America* (1956)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text E. O. Hulburt, "Some Recent Papers in the Journal of the Optical Society of America*," J. Opt. Soc. Am. 46, 5-9 (1956) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Dynamic registration for augmented reality in telerobotics applications (2002)

The paper presents a solution to the dynamic registration problem in augmented reality for telerobotics applications. The objective is to align the virtual camera used to render a 3D graphical replica of a robot manipulator with the real camera, providing images from the work site. We proceed in two steps: first, a static registration process requiring the intervention of the operator; next, a dynamic registration process that continuously and automatically updates the registration data. Our dynamic algorithm relies on feature tracking and an extended Kalman filter for state estimation. We present experimental results for the dynamic registration algorithm and discuss possible extensions and improvements of the method.
The Active Center of Co–N–C Electrocatalysts for the Selective Reduction of CO<sub>2</sub> to CO Using a Nafion-H Electrolyte in the Gas Phase (2020)

To contribute a solution for the global warming problem, the selective electrochemical reduction of CO<sub>2</sub> to CO was studied in the gas phase using a [CO<sub>2</sub>(g), Co-N-C cathode | Nafion-H | Pt/C anode, H<sub>2</sub>/water] system without using carbonate solutions. The Co-N-C electrocatalysts were synthesized by partial pyrolysis of precursors in inert gas, which were prepared from various N-bidentate ligands, Co(NO<sub>3</sub>)<sub>2</sub>, and Ketjenblack (KB). The most active electrocatalyst was Co-(4,4'-dimethyl-2,2'-bipyridine)/KB pyrolyzed at 673 K, denoted Co-4,4'-dmbpy/KB(673K). A high performance of CO formation (331 μmol h<sup>-1</sup> cm<sup>-2</sup>, 217 TOF h<sup>-1</sup>) at 0.020 A cm<sup>-2</sup> with 78% current efficiency was obtained at -0.75 V (SHE) and 273 K under strong acidic conditions of Nafion-H. Characterization studies using extended X-ray absorption fine structure (EXAFS), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy-energy-dispersive X-ray (TEM-EDX), X-ray diffraction (XRD), and temperature-programmed desorption with mass spectrometry (TPD-MS) indicated the active site as Co coordinated with four N atoms bonding the surface of KB, abbreviated Co-N<sub>4</sub>-C <i><sub>x</sub></i> structure. A model of the reduction mechanism of CO<sub>2</sub> on the active site was proposed.
Efficient and Retargetable Dynamic Binary Translation on Multicores (2013)

Dynamic binary translation (DBT) is a core technologyto many important applications such as system virtualization, dynamic binary instrumentation, and security. However, there are several factors that often impede its performance: 1) emulation overhead before translation; 2) translation and optimization overhead; and 3) translated code quality. The issues also include its retargetabilitythat supports guest applications from different instruction-set architectures (ISAs) to host machines also with different ISAs-an important feature to system virtualization. In this work, we take advantage of the ubiquitous multicore platforms, and use a multithreaded approach to implement DBT. By running the translator and the dynamic binary optimizer on different cores with different threads, it could off-load the overhead incurred by DBT on the target applications; thus, afford DBT of more sophisticated optimization techniques as well as its retargetability. Using QEMU (a popular retargetable DBT for system virtualization) and Low-Level Virtual Machine (LLVM) as our building blocks, we demonstrated in a multithreaded DBT prototype, called Hybrid-QEMU (HQEMU), that it could improve QEMU performance by a factor of 2.6x and 4.1x on the SPEC CPU2006 integer and floating point benchmarks, respectively, for dynamic translation of x86 code to run on x86-64 platforms. For ARM codes to x86-64 platforms, HQEMU can gain a factor of 2.5x speedup over QEMU for the SPEC CPU2006 integer benchmarks. We also address the performance scalability issue of multithreaded applications across ISAs. We identify two major impediments to performance scalability in QEMU: 1) coarse-grained locks used to protect shared data structures, and 2) inefficient emulation of atomic instructions across ISAs. We proposed two techniques to mitigate those problems: 1) using indirect branch translation caching (IBTC) to avoid frequent accesses to locks, and 2) using lightweight memory transactions to emulate atomic instructions across ISAs. Our experimental results show that for multithread applications, HQEMU achieves 25X speedups over QEMU for the PARSEC benchmarks.
‘Upenamide:  An Unprecedented Macrocyclic Alkaloid from the Indonesian Sponge<i>Echinochalina</i>sp. (2000)

‘Upenamide (1) represents a new class of macrocyclic marine alkaloid possessing both spirooxaquinolizidinone and hemiaminal ring systems. It was isolated from the Indonesian sponge Echinochalina sp. The gross structure of 1 was elucidated by spectroscopic methods and accurate mass measurements. A suggestion is made as to its biogenetic origin.
Building layer-by-layer 3D supramolecular nanostructures at the terephthalic acid/stearic acid interface (2011)

By using the layer-by-layer deposition method, we build three dimensional (3D) supramolecular nanostructures by stacking small molecular species on top of the first buffer layer, which can be utilized to fabricate novel 3D supramolecular functional nanostructures.
[The ultrasonic diagnosis of lesions of the hepatobiliary system in protracted forms of viral hepatitis in children]. (1993)

Ultrasound examination of the hepatobiliary system was carried out in 102 children (3-12 years) with viral hepatitis A and B on the 57-75 days of the disease. Increased liver size and swelling of the parenchyma was revealed in 100% of patients. Thickening of the gallbladder walls was similarly frequent in A and B hepatitis. In 40% deformation of the gallbladder was revealed in 40.1%. The pancreas was increased in 13.6%, indurated in 36.4% of patients. Changes in the gallbladder and cholangitis are clearly related to the level of bilirubinemia ALT activity that is one of the causes of delayed convalescence.
¡Ya sé quién eres, microorganismo! (2003)

Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the synthesis of cholesteryl esters from cholesterol and long-chain fatty acids. The two ACAT enzymes, ACAT1 and ACAT2, lack sterol regulatory elements in their promoters and have not been thought to be transcriptionally regulated by cellular cholesterol. However, Cynomolgus monkeys respond to high-cholesterol diet with increased hepatic ACAT2 mRNA expression. Also, a decrease in hepatic ACAT2 mRNA expression has been observed during statin treatment in humans. Thus, we hypothesized that cholesterol may exert transcriptional regulation on the human ACAT2 gene. To test this, we studied two human hepatoma cell lines (HuH7 and HepG2) under conditions of cholesterol loading or depletion and analyzed ACAT gene expression, enzymatic activity, and cellular cholesterol mass. We show a dose-dependent increase of ACAT2 mRNA expression, an increased enzymatic activity of ACAT2, and increased esterified cholesterol mass upon cholesterol loading. These results suggest that human ACAT2 is transcriptionally regulated by cholesterol.
Non-monotonic enumeration of layout alternative [i.e., alternatives] using the LOOS operators (2018)

Abstract: "This report develops a control function for application of the generation rules used in the LOOS system (Flemming et al. 88a) that does not keep the spatial relations between rectangles invariant. Such a control function is preferable to the one used in past versions of LOOS when certain forms of user interaction with the generation process are desired."
The PROGRESS study (1995)

The primary study outcome is total strokes and secondary outcomes include fatal or disabling strokes, total major cardiovascular events, cardiovascular deaths, cognitive function and dementia, and disability and dependency.
Submilliampere lasing of Zn-diffused mesa buried-hetero Al <sub> <i>x</i> </sub> Ga <sub> 1- <i>x</i> </sub> As/GaAs multi-quantum-well lasers at 77 K (1986)

Extremely low-threshold semiconductor lasers were fabricated by forming Zn-diffused mesa buried-hetero (DMB) structures from low-pressure MOCVD-grown AlxGa1-xAs/GaAs multi-quantum-well, separate-confinement heterostructure wafers. CW threshold currents as low as 880 μA at 77 K and 2.4 mA at room temperature were obtained for a 100 μm-long device.
Delayed-choice experiments in quantum interference (1987)

Following a suggestion by Wheeler, we have performed delayed-choice experiments in both the spatial and time domains. For the first experiment we use a low-intensity Mach-Zehnder interferometer, and for the second the technique of quantum beats in time-resolved atomic fluorescence. The results obtained show no observable difference between normal and delayed-choice modes of operation, in agreement with the predictions of quantum mechanics.
Membrane-type acoustic metamaterials with tunable frequency by a compact magnet (2019)

In this letter, a membrane-type acoustic metamaterial with a compact magnet (MAMM) is presented. To investigate its frequency-tunable properties, a theoretical model considering both static and dynamic effects of magnetic force is established. Analytical investigations indicate that tuning of the magnetic force exerted on the centralized rigid iron platelet leads to the shift in the MAMM's transmission loss peaks. The experimental anti-resonance frequencies of the MAMM derived from the impedance tube measurements exhibited good consistency with those predicted theoretically. Continuously tuned in a wide frequency range, this structure can well adapt to the noise source variation in insulation design.
Design of small reverberation chamber for handsets testing (2008)

This paper presents the design procedures and 3-D full-wave simulations of the electromagnetic field inside a small-sized reverberation chamber. The electric field inside the chamber is computed and the influence of small geometric details and asymmetries is investigated as well as the effect of different excitations and stirrers, and thus represents a reliable tool facilitating reverberation chamber optimization. The small reverberation chamber having dimensions 1.16times0.75times1.1 m3 is designed for investigations of handset antenna terminals.
What the media are doing to our politics (2005)

This paper describes the role of the media in a free society and their impact on civic life. Intellectual rigour in journalism is required to assist media to develop and understand itself.
Generic Detection of Coronaviruses and Differentiation at the Prototype Strain Level by Reverse Transcription-PCR and Nonfluorescent Low-Density Microarray (2007)

A nonfluorescent low-cost, low-density oligonucleotide array was designed for detecting the whole coronavirus genus after reverse transcription (RT)-PCR. The limit of detection was 15.7 copies/reaction. The clinical detection limit in patients with severe acute respiratory syndrome was 100 copies/sample. In 39 children suffering from coronavirus 229E, NL63, OC43, or HKU1, the sensitivity was equal to that of individual real-time RT-PCRs.
Outbreak of Carbapenem-Resistant <i>Pseudomonas aeruginosa</i> Producing VIM-8, a Novel Metallo-β-Lactamase, in a Tertiary Care Center in Cali, Colombia (2004)

The prevalence of imipenem resistance among Pseudomonas aeruginosa isolates at a 195-bed tertiary care medical center in Cali, Colombia, rose from 2% in 1996 to 28% in 1997 and to over 40% in 2003. Many isolates showed high-level multiresistance, and phenotypic characterization suggested the spread of a predominant strain with minor variants. Sixty-six resistant isolates collected between February 1999 and July 2003 from hospitalized patients (n = 54) and environmental samples (n = 12) were subjected to a fuller analysis. Genetic fingerprints were compared by pulsed-field gel electrophoresis (PFGE) of SpeI-digested genomic DNA, and bla(IMP) and bla(VIM) genes were sought by PCR. PFGE and serotyping indicated that 52 of the 66 isolates belonged to a single strain, with 82% similarity; the PFGE pattern for this organism was designated pattern A. Two further pairs of isolates represented single strains; the remaining nine isolates were unique, and in the case of one isolate, no satisfactory PFGE profile could be obtained. The pattern A isolates were mostly of serotype O12 and were highly resistant to imipenem (MICs, 32 to >256 microg/ml), with this resistance decreased eightfold or more in the presence of EDTA. They yielded amplicons with bla(VIM)-specific primers, and sequencing of DNA from a representative isolate revealed bla(VIM-8), a novel allele with three polymorphisms compared with the sequence of bla(VIM-2). Two of these nucleotide changes were silent, but the third determined a Thr139Ala substitution. Only 4 of 13 resistant isolates (2 clinical isolates and 2 environmental isolates) assigned to other PFGE types carried bla(VIM) alleles, whereas the others were less multiresistant and mostly had lower levels of imipenem resistance (MICs, < or =32 microg/ml) which was not significantly reduced by EDTA. No bla(IMP) alleles were detected. During 2003, when the environmental study was undertaken, serotype O12 isolates with bla(VIM) were recovered from sinks and stethoscopes in the most-affected units, although not from the hands of staff; the problem declined once these reservoirs were disinfected and hygienic precautions were reinforced.
ChemInform Abstract: NITROHETEROCYCLICS OF CHEMOTHERAPEUTIC INTEREST. I. SYNTHESIS, POLAROGRAPHY AND ANTIPARASITIC ACTIVITIES OF THIAZOLE AND PYRIDINE ANALOGS (1981)

Abstract Die Thioether (II) bzw. (V) werden aus dem Bromthiazol (I) dargestellt.
Targeting host kinases for the treatment of herpes keratitis (2012)

Abstract Purpose Herpes keratitis (HK) is a common cause of blindness in the developed world. A large number of HK cases are refractory to antiviral agents and ultimately result in permanent corneal damage. The purpose of this study is to identify new therapeutic targets against HSV and to assess their antiviral potential in tissue culture experiments, as well as in more sophisticated models of HK. Specifically, we focused on the involvement of ataxia telangiectasia mutated (ATM) and its downstream target Chk2 in facilitating productive HSV infection in corneal epithelium. Methods We used human corneal epithelial cell lines – hTCEpi and HCE – as in vitro models of corneal HSV infection, and also developed an ex vivo model of acute corneal epithelial infection, where explanted human and rabbit corneoscleral buttons were infected and maintained in organ culture. We are currently utilizing an in vivo mouse model of ocular herpes to further validate our findings. Small molecule inhibitors of ATM (KU‐55933, wortmannin, caffeine) and Chk2 (Chk2 inhibitor II), as well as RNAi against ATM and Chk2, were used to inhibit these two kinases. We used plaque assays and qPCR to assess the infectious particle production, genome replication, and transcriptional activity of HSV in corneal epithelium. Results Small molecule or RNAi‐mediated inhibition of ATM or Chk2 greatly suppressed the replication and transcription of the viral genome, as well as the infectious particle production. This was observed in the tissue culture models and, importantly, in organotypically explanted human and rabbit corneas. Results of the animal studies will also be presented. Conclusion This study identifies two host kinases – ATM and Chk2 – as potential novel therapeutic targets against herpes keratitis.