gebhart/patrepeval huggingface dataset:
Chitosan as an ingredient for domestic animal feeds (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChitosan as an ingredient for domestic animal feedsShigehiro Hirano, Chitoshi Itakura, Haruyoshi Seino, Yasutoshi Akiyama, Isao Nonaka, Naoki Kanbara, and Toshihiro KawakamiCite this: J. Agric. Food Chem. 1990, 38, 5, 1214–1217Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/jf00095a012https://doi.org/10.1021/jf00095a012research-articleACS PublicationsRequest reuse permissionsArticle Views637Altmetric-Citations167LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Overexpression of <i>SOD2</i> Increases Salt Tolerance of Arabidopsis (2003)

The yeast (Schizosaccharomyces pombe) SOD2 (Sodium2) gene was introduced into Arabidopsis under the control of the cauliflower mosaic virus 35S promoter. Transformants were selected for their ability to grow on medium containing kanamycin. Southern- and northern-blot analyses confirmed that SOD2 was transferred into the Arabidopsis genome. There were no obvious morphological or developmental differences between the transgenic and wild-type (wt) plants. Several transgenic homozygous lines and wt plants (control) were evaluated for salt tolerance and gene expression. Overexpression of SOD2 in Arabidopsis improved seed germination and seedling salt tolerance. Analysis of Na+ and K+ contents of the symplast and apoplast in the parenchyma cells of the root cortex and mesophyll cells in the spongy tissue of the leaf showed that transgenic lines accumulated less Na+ and more K+ in the symplast than the wt plants did. The photosynthetic rate and the fresh weight of the transgenic lines were distinctly higher than that of wt plants after NaCl treatment. Results from different tests indicated that the expression of the SOD2 gene promoted a higher level of salt tolerance in vivo in transgenic Arabidopsis plants.
Abstract 2302: An ‘off the shelf,’ GMP-grade, IL-2-independent NK cell line expressing the high-affinity Fc-receptor to augment antibody therapeutics (2016)

Abstract A number of approved IgG1 monoclonal antibodies (mAb) used in cancer therapy, including trastuzumab, cetuximab, and rituximab, depend on natural killer (NK) cell-mediated antibody dependent cell-mediated cytotoxicity (ADCC) to induce cancer cell death, mediated through the Fcγ receptor (FcγR). Multiple studies report that survival benefit is significantly improved in cancer patients receiving IgG1 antibody therapy who have NK cells that express the high-affinity FcγRIIIa receptor (CD16-158V). Only 12% of the normal human population, however, is homozygous for expression of this high-affinity variant CD16. We hypothesized that infusion of an NK-92 cell line modified to express CD16-158V (high-affinity NK cells [haNK]) in combination with an IgG1 mAb may result in superior antitumor effects compared with IgG1 mAb alone. A GMP-grade plasmid-transfected variant of NK-92 expressing the high-affinity CD16 receptor was developed utilizing a novel transfection vector containing the erIL-2 gene, enabling the resulting haNK cells to grow independently of IL-2. Using limiting dilution, clones having identical surface molecule expression to the parent cell line were generated and shown to have long-term expression of CD16. The haNK cells displayed high ADCC in combination with rituximab, trastuzumab, and daratumumab against target cell lines that were not killed by the parental NK-92 cells. Of note, despite non-viral transfection, the plasmid is fully integrated into chromosome 5. The haNK cell line secretes about 200 pg/106 cells of IL-2, and like the parental NK-92 cell line, produces enough IFNγ to potentially stimulate an adaptive immune response. A GMP-grade master cell bank of haNK cells has been established; haNK cells can be cryopreserved with retention of ADCC activity. In vivo studies demonstrated the efficacy of haNK cells. In a multiple myeloma model of CD38+ NCI-H929 cells xenografted into NOD/SCID gamma null (NSG) mice, treatment with haNK cells plus the anti-CD38 mAb daratumumab led to prolonged survival versus mice treated with haNK cells plus an isotype control (log rank p = 0.0169), demonstrating therapeutically relevant in vivo ADCC. haNK cells have also been transfected with various CARs using mRNA, thereby enabling this platform to make a bispecific effector cell product. In summary, haNK cells are a potent and versatile platform for cellular immunotherapy, and clinical trials of these novel “off the shelf” high-affinity NK cells are scheduled for 2016. Citation Format: Laurent Boissel, Hans Klingemann, Kerry Campbell, Karen Nichols, Frances Toneguzzo, Paula Marcus, Brent Williams, Armand Keating, Patrick Soon-Shiong. An ‘off the shelf,’ GMP-grade, IL-2-independent NK cell line expressing the high-affinity Fc-receptor to augment antibody therapeutics. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2302.
The impact of new standards and new technological solutions on process information modelling (2012)

This paper represents the basic concepts for a process information model that will satisfy all the needs of a modern power system under the circumstances of new technological achievements and standards in power sector. New technological solutions that are used in substation automation systems are shown. Previous process information model used in the power system are presented. Basic concepts to define a new power system substation process information model are presented.
Weathering of Pisha-Sandstones in the Wind-Water Erosion Crisscross Region on the Loess Plateau (2008)

紫色沙岩和灰色的沙岩的 pisha 沙岩的二种类型，广泛地在中国的风水侵蚀十字区域散布，为捱过过程源于水或盐答案的分配摇样品的 drying-wetting-freezing 的更好的理解在实验室实验被选择并且使用。捱过实验在环境控制(包括的温度，潮湿和盐答案) 的条件下面被执行。所有岩石样品经常受到 140 个 drying-wetting-freezing 周期。捱过过程的影响被评估。潮湿和盐答案应用的不同处理能影响源于 drying-wetting-freezing 的捱过的产品的性质，这被发现。盐答案能有效地减轻捱过 pisha 沙岩，这也被观察。尽管并非所有观察能被解释，模仿的环境因素在捱过岩石上有直接、间接的效果，是明显的。
Conflict and combination in privacy policy languages (2004)

Many modern enterprises require methods for guaranteeing compliance with privacy legislation and announced privacy policies. IBM has proposed a formal language, the Enterprise Privacy Authorization Language (EPAL), for describing privacy policies rigorously. In this paper, we identify four desirable properties of a privacy policy language: guaranteed consistency, guaranteed safety, admitting local reasoning, and closure under combination. While EPAL achieves only one of these four goals, an extended language framework allows us to achieve three out of four, while retaining the basic EPAL framework of restricting access and imposing obligations on users of confidential information.
The mTOR Pathway in the Control of Protein Synthesis (2006)

Signaling through mammalian target of rapamycin (mTOR) is activated by amino acids, insulin, and growth factors, and impaired by nutrient or energy deficiency. mTOR plays key roles in cell physiology. mTOR regulates numerous components involved in protein synthesis, including initiation and elongation factors, and the biogenesis of ribosomes themselves.
Neural-Network-Based System for Novel Fault Detection in Rotating Machinery (2004)

The purpose of this research is the realization of a method for machine health monitoring. The rotating machinery of the Refinery of Milazzo (Italy) was analyzed. A new procedure, incorporating neural networks, was designed and realized to evaluate the vibration signatures and recognize the fault presence. Neural networks have replaced the traditional expert systems, used in the past for the fault diagnosis, because they are a dynamic system and thus adaptable to continuously variable data. The disadvantage of common neural networks is that they need to be trained by real examples of different fault typologies. The innovative aspect of the new procedure is that it allows us to diagnose faults, which are not considered in the training set. This ability was demonstrated by our analysis; the net was able to detect the presence of imbalance and bearing wear, even if these typologies of faults were not present in the training data set.
Risks and Safeguards of the Spywares (2005)

Spyware is any software which employs a user's Internet connection in the background without their knowledge or explicit permission. The installation of spywares is generally done in a sneaky, misleading or unannounced manner. It does not only compromise the security and privacy of affected users but also be an obstruction to the digital convergence and ubiquitous computing environments. This paper provides a summary of the definition, status, risk analysis, and security controls of the spywares. Furthermore, this paper suggests additional controls which should be considered at an individual, organizational and national perspective.
GR-S Emulsified with Rosin Soap (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGR-S Emulsified with Rosin SoapG. R. Cuthbertson, W. S. Coe, and J. L. BradyCite this: Ind. Eng. Chem. 1946, 38, 9, 975–976Publication Date (Print):September 1, 1946Publication History Published online1 May 2002Published inissue 1 September 1946https://pubs.acs.org/doi/10.1021/ie50441a028https://doi.org/10.1021/ie50441a028research-articleACS PublicationsRequest reuse permissionsArticle Views18Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Notes on the Study of History (1880)

Cicero's definition of history as “the lamp of truth” can be accepted only when the events of history are recorded accurately. The writer who travesties historical facts poisons the fountain of knowledge, misrepresents the ancients, misleads his contemporaries, and deceives future generations. Mindful of his responsibility the faithful historian is exact in his narrative, avoiding undue panegyric on the one hand, and on the other rash denunciation. He regards history as a science in which truth is dissociated from falsehood; an art by means of which past events are to be recorded so as to produce a present interest.
Ag Nanoparticle Paste Synthesis for Room Temperature Bonding (2009)

Time-dependent sintering properties of an Ag nanoparticle paste for room temperature bonding were investigated. Ag nanoparticle paste with a small amount of dodecylamine dispersant can sinter at room temperature by the evaporation of toluene solvent. When the solvent evaporates, sintering with neck growth and the coalescence of particles is initiated within half an hour and the Ag grain continues to grow gradually for hours. Furthermore, a time-dependent change in the shear strength is demonstrated using a bonding test with Cu plates at room temperature. Bonding between the Ag paste and a Cu plate is favorable and fracturing occurs within the sintered Ag body. The strength of sintered Ag increases with sintering time due to neck growth and the coalescence of particles. The shear strength is more than 8 MPa after 6 h and 12 h of drying.
Combined Efficacy of an Antimicrobial Cationic Peptide Polymer with Conventional Antibiotics to Combat Multidrug-Resistant Pathogens (2020)

Antibiotic-resistant infections are predicted to kill 10 million people worldwide per year by 2050 and to cost the global economy 100 trillion USD. Novel approaches and alternatives to conventional antibiotics are urgently required to combat antimicrobial resistance. We have synthesized a chitosan-based oligolysine antimicrobial peptide, CSM5-K5 (where CSM denotes chitosan monomer repeat units and K denotes lysine amino acid repeat units), that targets multidrug-resistant (MDR) bacterial species. Here, we show that CSM5-K5 exhibits rapid bactericidal activity against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), MDR <i>Escherichia coli</i>, and vancomycin-resistant <i>Enterococcus faecalis</i> (VRE). Combinatorial therapy of CSM5-K5 with antibiotics to which each organism is otherwise resistant restores sensitivity to the conventional antibiotic. CSM5-K5 alone significantly reduced preformed bacterial biofilm by 2-4 orders of magnitude and, in combination with conventional antibiotics, reduced preformed biofilm by more than 2-3 orders of magnitude at subinhibitory concentrations. Moreover, using a mouse excisional wound infection model, CSM5-K5 treatment reduced bacterial burdens by 1-3 orders of magnitude and acted synergistically with oxacillin, vancomycin, and streptomycin to clear MRSA, VRE, and MDR <i>E. coli</i>, respectively. Importantly, little to no resistance against CSM5-K5 arose for any of the three MDR bacteria during 15 days of serial passage. Furthermore, low level resistance to CSM5-K5 that did arise for MRSA conferred increased susceptibility (collateral sensitivity) to the β-lactam antibiotic oxacillin. This work demonstrates the feasibility and benefits of using this synthetic cationic peptide as an alternative to, or in combination with, traditional antibiotics to treat infections caused by MDR bacteria.
Hyperoxia, Endothelial Progenitor Cell Mobilization, and Diabetic Wound Healing (2008)

Diabetic foot disease is a major health problem, which affects 15% of the 200 million patients with diabetes worldwide. Diminished peripheral blood flow and decreased local neovascularization are critical factors that contribute to the delayed or nonhealing wounds in these patients. The correction of impaired local angiogenesis may be a key component in developing therapeutic protocols for treating chronic wounds of the lower extremity and diabetic foot ulcers. Endothelial progenitor cells (EPCs) are the key cellular effectors of postnatal neovascularization and play a central role in wound healing, but their circulating and wound-level numbers are decreased in diabetes, implicating an abnormality in EPC mobilization and homing mechanisms. The deficiency in EPC mobilization is presumably due to impairment of eNOS-NO cascade in bone marrow (BM). Hyperoxia, induced by a clinically relevant hyperbaric oxygen therapy (HBO) protocol, can significantly enhance the mobilization of EPCs from the BM into peripheral blood. However, increased circulating EPCs failed to reach to wound tissues. This is partly a result of downregulated production of SDF-1alpha in local wound lesions with diabetes. Administration of exogenous SDF-1alpha into wounds reversed the EPC homing impairment and, with hyperoxia, synergistically enhanced EPC mobilization, homing, neovascularization, and wound healing.
A palladium-catalyzed route to huperzine A and its analogs and their anticholinesterase activity (1993)

Huperzine A is an alkaloid isolated from Huperzia serrata (Thunb.) Trev., a Chinese club moss the extracts of which have been used in Chinese folklore medicine to treat a variety of maladies including memory disorders. Recently, this molecule has attracted widespread attention because of its possible use in the treatment of Alzheimer's disease (AD). We describe herein a palladium-catalyzed bicycloannulation route to this molecule which makes huperzine A available in 40% overall yield. The application of this methodology to seven other huperzine A analogues together with their biological activity in the inhibition of rat cortex acetylcholinesterase (AChE) is detailed herein. None of these new compounds was more potent than the parent structure as AChE inhibitors.
A Case of Budd-Chiari Syndrome Associated with Polycythemia Vera. (1997)

症例は43歳, 女性. 1993年9月頃より腹水の貯留, 黄疸が出現し, 1994年1月入院. 血液検査では全血球系の著増とともに著明な肝障害が認められた. 血液所見および骨髄生検より真性多曲症ならびに急性肝不全と診断した. また腹部超音波検査にて右・中・左肝静脈は血栓で充満し面流は認められず, 血栓による肝静脈の閉塞が考えられた. 入院後急速に肝不全が進行し, 1カ月の経過でDIC, 多臓器不全のため死亡. 病理解剖では肝静脈内に器質化した血栓が認められ, 肝細胞はzone 3を中心に広範な変性, 壊死を示していた. 本邦におけるBudd-Chiari症候群の多くは膜様閉塞に伴うものであり, 肝静脈血栓によるBudd-Chiari症候群の報告は少ない. 特に真性多血症に伴う肝静脈閉塞は本例を含め2例のみで極めて稀な症例と考えられる.
A new A/D converter with quantum flux parametron (1989)

A flash-type superconducting A/D (analog/digital) converter is proposed. The basis low-frequency operation of this converter, which compromises a quantum flux parametron (QFP) and an RF SQUID (superconducting quantum interference device), has been observed. The RF SQUID consists of a Josephson junction and a load inductor which is part of the QFP. It converts an analog signal to period digital signals of one quantum flux (2.07*10/sup -5/ W-b) per cycle. The QFP works as both an amplifier and a comparator of the periodic digital signals, by adding an exciting signal. This A/D converter is expected to achieve high-speed operation of 20 GHz. Several 4-bit A/D converter circuits were fabricated, using the conventional Nb-Pb alloy process, with a junction size of 5 mu m*5 mu m and supercurrent density of 200 A/cm/sup 2/. Basic operation at 100 KHz was confirmed experimentally.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A study on nanofiber‐reinforced thermoplastic composites (II): Investigation of the mixing rheology and conduction properties (2001)

Abstract This article is portion of a comprehensive study on the development of nanofiber‐reinforced polymer composites for electrostatic discharge materials and structural composites. Vapor‐grown carbon fibers with an average diameter of 100 nm were used as a precursor and model fiber system for carbon nanotubes. These nanofibers were purified and functionalized to provide for an open network of high‐purity nanofibers. Banbury‐type mixing was used to disperse the nanofibers in the polymer matrix. Rheological and microscopic analysis showed that the high shear processing of the polymer/nanofiber mixture led to a homogeneous dispersion of nanofibers with no agglomerates present and no shortening of the nanofibers. The shear thinning behavior of polymeric materials helps in the mixing of the nanofibers to form the composites. A percolation threshold for electrical conduction of 9–18 wt % was observed for the highly dispersed nanofiber networks. The electrical behavior of these materials was not affected by changes in humidity. Microscopic analysis showed highly dispersed nanofibers with no indications of porosity. These conducting polymers are well suited for electrostatic discharge applications, and might well become multifunctional materials for strength/electrical applications. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 80: 1162–1172, 2001
Bile Salt-Stimulated Lipase from Human Milk Binds DC-SIGN and Inhibits Human Immunodeficiency Virus Type 1 Transfer to CD4 <sup>+</sup> T Cells (2006)

A wide range of pathogens, including human immunodeficiency virus type 1 (HIV-1), hepatitis C virus, Ebola virus, cytomegalovirus, dengue virus, Mycobacterium, Leishmania, and Helicobacter pylori, can interact with dendritic cell (DC)-specific ICAM3-grabbing nonintegrin (DC-SIGN), expressed on DCs and a subset of B cells. More specifically, the interaction of the gp120 envelope protein of HIV-1 with DC-SIGN can facilitate the transfer of virus to CD4+ T lymphocytes in trans and enhance infection. We have previously demonstrated that a multimeric LeX component in human milk binds to DC-SIGN, preventing HIV-1 from interacting with this receptor. Biochemical analysis reveals that the compound is heat resistant, trypsin sensitive, and larger than 100 kDa, indicating a specific glycoprotein as the inhibitory compound. By testing human milk from three different mothers, we found the levels of DC-SIGN binding and viral inhibition to vary between samples. Using sodium dodecyl sulfate-polyacrylamide gel electrophoresis, Western blotting, and matrix-assisted laser desorption ionization analysis, we identified bile salt-stimulated lipase (BSSL), a Lewis X (LeX)-containing glycoprotein found in human milk, to be the major variant protein between the samples. BSSL isolated from human milk bound to DC-SIGN and inhibited the transfer of HIV-1 to CD4+ T lymphocytes. Two BSSL isoforms isolated from the same human milk sample showed differences in DC-SIGN binding, illustrating that alterations in the BSSL forms explain the differences observed. These results indicate that variations in BSSL lead to alterations in LeX expression by the protein, which subsequently alters the DC-SIGN binding capacity and the inhibitory effect on HIV-1 transfer. Identifying the specific molecular interaction between the different forms may aid in the future design of antimicrobial agents.
DNA methylation in ductal carcinoma in situof the breast (2013)

Ductal carcinoma in situ (DCIS) is a non-obligate precursor lesion of invasive carcinoma of the breast. Current prognostic markers based on histopathological examination are unable to accurately predict which DCIS cases will progress to invasive carcinoma or recur after surgical excision. Epigenetic changes have been shown to be a significant driver of tumorigenesis, and DNA methylation of specific gene promoters provides predictive and prognostic markers in many types of cancer, including invasive breast cancer. In general, the spectrum of genes that are methylated in DCIS strongly resembles that seen in invasive ductal carcinoma. The identification of specific prognostic markers in DCIS remains elusive and awaits additional work investigating a large panel of methylatable genes by using sensitive and reproducible technologies. This review critically appraises the role of methylation in DCIS and its use as a biomarker.
Subclinical myocardial inflammation and diffuse fibrosis are common in systemic sclerosis – a clinical study using myocardial T1-mapping and extracellular volume quantification (2014)

Cardiac involvement is common in SSc even in the absence of cardiac symptoms, and includes chronic myocardial inflammation as well as focal and diffuse myocardial fibrosis. Myocardial abnormalities detected on CMR were associated with impaired strain parameters, as well as disease activity and severity in SSc patients. CMR may be useful in future in the study of treatments aimed at preventing or reducing adverse myocardial processes in SSc.