gebhart/patrepeval huggingface dataset:
ASIC design flow considering lithography-induced effects (2008)

As VLSI technology scales towards 65 nm and beyond, both timing and power performance of integrated circuits are increasingly affected by process variations. In practice, people often treat systematic components of the variations, which are generally traceable according to process models, in the same way as random variations in process corner-based methodologies. In particular, lithography-induced process variations are usually estimated by a universal worst-case value without considering their layout environment. Consequently, the process corner models based on such estimation are unnecessarily pessimistic. A new ASIC design methodology that captures lithography-induced polysilicon gate length variations including both the layout dependent systematic components and random components is proposed. This methodology also shows that lookup table methodology is sufficient to handle back end of line lithography process variations in timing analysis. In addition, a new technique of dummy poly insertion is suggested to shield inter-cell optical interferences. This technique together with standard cells characterised using the new methodology will let current design flows comprehend the variations almost without any changes. More importantly, by separating systematic lithography effect from random process variations, this methodology greatly reduces pessimism in timing analysis, thus enabling both aggressive design implementation and easier timing signoff. Experimental results on industrial designs indicate that the new methodology can averagely reduce timing variation window by 11% and power variation window by 55% when compared with a worst-case approach.
Methods for monitoring outdoor populations of house flies, Musca domestica L. (Diptera: Muscidae). (2005)

Relative collections of house flies were compared on two Florida dairy farms using several monitoring methods: sticky cylinders, baited jug traps (Farnam Terminator and Victor Fly Magnet), and bait strips (Wellmark QuikStrike). Bait strips were placed over collecting pans and under 61 cm square plywood roofs to protect the toxicant from sunlight ("sheltered QuikStrike traps"). Sticky cylinders collected the fewest flies (515-679 flies/trap/day) and sheltered QuikStrike traps the most (5,659-8,814 flies/trap/day). The sheltered QuikStrike traps are promising tools for disease surveillance programs. The two baited jugs collected a similar and intermediate number of flies, with collections highest during the first 2 days after placement (2,920-5,462 flies/trap/day). Jug trap collections were low after 4 days of use in the field, apparently due to deterioration in the attractiveness of the bait over time. Jug traps collected mostly females, whereas sticky cylinders and sheltered QuikStrike traps collected mostly males. Exposure of jug trap bait (Farnam) to fly cadavers for 3 days did not increase attractiveness of the bait. Combinations of the Farnam and Victor attractants were more attractive than either attractant alone and 25-43% more attractive than expected based on the sum of collections in the single-attractant jug traps. A 25% solution of farm-grade blackstrap molasses was as effective as either of the two proprietary baits tested, offering a low-cost alternative for fly population monitoring.
Measurement delay associated with the Guardian® RT continuous glucose monitoring system (2009)

In young subjects with T1D, the total time delay associated with the Guardian RT system was approximately 15 min. This is twice that expected on physiological grounds, suggesting a 5- to 10-min delay because of data processing. Delays above 25 min are rarely to be observed.
Angiotensin II Induces Catecholamine Release by Direct Ganglionic Excitation (2002)

Angiotensin II (ANG) is known to facilitate catecholamine release from peripheral sympathetic neurons by enhancing depolarization-dependent exocytosis. In addition, a direct excitation by ANG of peripheral sympathetic nerve activity has recently been described. This study determined the significance of the latter mechanism for angiotensin-induced catecholamine release in the pithed rat. Rats were anesthetized and instrumented for measuring either hemodynamics and renal sympathetic nerve activity or plasma catecholamine concentrations in response to successively increasing doses of angiotensin infusions. Even during ganglionic blockade by hexamethonium (20 mg/kg), angiotensin dose-dependently elevated sympathetic nerve activity, whereas blood pressure-equivalent doses of phenylephrine were ineffective. Independently of central nervous sympathetic activity and ganglionic transmission, angiotensin (0.1 to 1 microg/kg) also induced an up-to 27-fold increase in plasma norepinephrine levels, reaching 2.65 ng/mL. Preganglionic electrical stimulation (0.5 Hz) raised basal norepinephrine levels 11-fold and further enhanced the angiotensin-induced increase in norepinephrine (4.04 ng/mL at 1 microg/kg ANG). Stimulation of sympathetic nerve activity and norepinephrine release were suppressed by candesartan (1 mg/kg) or tetrodotoxin (100 microg/kg), respectively. Angiotensin enhanced plasma norepinephrine, heart rate, and sympathetic nerve activity at similar threshold doses (0.3 to 1 microg/kg), but raised blood pressure at a significantly lower dose (0.01 microg/kg). It is concluded that direct stimulation of ganglionic angiotensin type 1 (AT(1)) receptors arouses electrical activity in sympathetic neurons, leading to exocytotic junctional catecholamine release. In both the absence and presence of preganglionic sympathetic activity, this mechanism contributes significantly to ANG-induced enhancement of catecholamine release.
CM247LC 초내열합금에서 일방향응고 스타트 블록의 초기 핵생성 조건에 따른 결정립 성장 (2011)

The grain size and growth direction of a directionally solidified turbine blade were evaluated by the initial nucleation condition at the start block of directional solidification. The initial nucleation condition was controlled by inserting a Ni foil on the directional solidification plate of the directional solidification furnace. Fine grains with good orientation were obtained in the faster cooling condition at the start block. The nucleus number was compared with the cooling rate of the start block by electron back scattered diffraction (EBSD). DSC (differential scanning calorimeter) analysis was performed to compare the melting point and undercooling for nucleation of the coarse nuclei and fine nuclei of the start block. The faster cooling condition at the start block showed more undercooling for nucleation and smaller size of nuclei which resulted in a fine grain with good orientation in the directional turbine blade.
CLINICAL EVALUATION OF THE CARDIOVASCULAR EFFECTS AND THE PHARMACOKINETICS OF BENALFOCIN AND ITS METABOLITE IN HEALTHY SUBJECTS DURING REPEATED DOSING (1988)

The cardiovascular effects and the pharmacokinetics of a new selective alpha-2 adrenoceptor antagonist, benalfocin, and its active metabolite, both compounds with a similar receptor affinity profile, were examined in healthy volunteers during repeated dosage. Significant diastolic blood pressure lowering effects were observed on the first and the last day of the treatment persisting throughout the dosage interval. Furthermore, heart rate reductions were found on these days which were significantly correlated with both the parent compound's and the metabolite's plasma concentrations and their sum. Pharmacokinetics remained unchanged after a 1-wk oral dosing as compared to a single oral dose; the plasma half-life of the metabolite was 3-fold longer than that of the parent compound. In normotensive subjects, benalfocin produced blood pressure and heart rate reducing effects, the latter being more correlated with the metabolite's plasma concentrations. Furthermore, results suggest that the compound's known cholinergic effects may be particularly related to the metabolite and that this molecule is an interesting cardiovascular compound.
Removing Interfering Contaminations from Gelatin Lifters (2005)

Gelatin lifter is widely used for recovering shoeprints from crime scenes. Dusty shoeprints removed from paper with loose fibers, cloth or plasterboard, might be concealed by the detached fibers. A novel technique to clean the gelatin lifter from the interfering contaminations, using adhesive lifters, was developed. The adhesive lifter is applied directly on the surface of the gelatin lifter, and is removed instantly. The adhesive lifter removes the upper layer of the attached material on the gelatin lifter. After removing the concealing material from the hidden imprint, the quality of the visualized imprint is improved. The cleaning process can be applied as many times as needed and the optimum number is different for each substrate. The small dust particles comprising the shoeprint remained attached to the sticky side of the gelatin lifter even though the adhesion force applied by the adhesive lifter is great. Repeating the procedure too many times could harm the quality of the print severely, yet the advantages of this method are greater than the risks of relocation of image quality reduction.
Locomotor-Related Networks in the Lumbosacral Enlargement of the Adult Spinal Cat: Activation Through Intraspinal Microstimulation (2006)

It is commonly accepted that locomotor-related neuronal circuitry resides in the lumbosacral spinal cord. Pharmacological agents, epidural electrical stimulation, and sensory stimulation can be used to activate these instrinsic networks in in vitro neonatal rat and in vivo cat preparations. In this study, we investigated the use of low-level tonic intraspinal microstimulation (ISMS) as a means of activating spinal locomotor networks in adult cats with complete spinal transections. Trains of low-amplitude electrical pulses were delivered to the spinal cord via groups of fine microwires implanted in the ventral horns of the lumbosacral enlargement. In contrast to published reports, tonic ISMS applied through microwires in the caudal regions of the lumbosacral enlargement (L7-S1) was more effective in eliciting alternating movements in the hindlimbs than stimulation in the rostral regions. Possible mechanisms of action of tonic ISMS include depolarization of locally oscillating networks in the lumbosacral cord, backfiring of primary afferents, or activation of propriospinal neurons.
Distributed digital-ticket management for rights trading system (1999)

Article Free Access Share on Distributed digital-ticket management for rights trading system Authors: Kazuo Matsuyama NTT Information Sharing Platform Laboratories, 1-1 Hikarinooka Yokosuka-Shi, Kanagawa 239-0847 Japan NTT Information Sharing Platform Laboratories, 1-1 Hikarinooka Yokosuka-Shi, Kanagawa 239-0847 JapanView Profile , Ko Fujimura NTT Information Sharing Platform Laboratories, 1-1 Hikarinooka Yokosuka-Shi, Kanagawa 239-0847 Japan NTT Information Sharing Platform Laboratories, 1-1 Hikarinooka Yokosuka-Shi, Kanagawa 239-0847 JapanView Profile Authors Info & Claims EC '99: Proceedings of the 1st ACM conference on Electronic commerceNovember 1999 Pages 110–118https://doi.org/10.1145/336992.337020Published:01 November 1999Publication History 21citation1,008DownloadsMetricsTotal Citations21Total Downloads1,008Last 12 Months52Last 6 weeks9 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Clairvoyant: a synthesis system for production-based specification (1994)

This paper describes a new high-level synthesis system based on the hierarchical production based specification (PBS). Advantages of this form of specification are that the designer does not describe the control flow in terms of explicit states or control variables, and that the designer does not describe a particular form of implementation. The production-based specification also separates the specification of the control aspects and data-flow aspects of the design. The control is implicitly described via the production hierarchy, while the data-flow is described as action computations. This approach is a hardware analog of popular software engineering techniques. The Clairvoyant system automatically constructs a controlling machine from the PBS and this process is not impacted by the possibly exponentially larger deterministic state space of the designs. The encodings generated by the constructions compare favorably to encodings derived using graph-based state encoding techniques in terms of logic complexity and logic depth. These construction techniques utilize recent advances in BDD techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Is the Answer Blowing in the Solar Wind? (1995)

In trying to understand the surprise, wonder and skepticism that have greeted the paper by David Thomson, Carol Maclennan and Louis Lanzerotti of AT&T Bell Labs in the 13 July issue of Nature, it helps to remember a few salient facts. First, the authors claim that the solar wind has components that oscillate in a coherent, stable manner. This claim contradicts the standard view that the solar wind is turbulent and possesses no long-lived structures, other than those associated with solar rotation and structure.
The La Silla-QUEST Low Redshift Supernova Survey (2013)

The La Silla-QUEST Low Redshift Supernova Survey is a part of the La Silla-QUEST Southern Hemisphere Variability Survey. The survey uses the 10 deg2 QUEST camera installed at the prime focus of the 1.0-m Schmidt Telescope of the European Southern Observatory at La Silla, Chile, and utilizes essentially all of the observing time of the telescope. The QUEST camera was installed on the ESO Schmidt telescope in 2009 after completing a 5 year variability survey in the northern hemisphere using the 1.2-m Oschin Schmidt telescope at Palomar. La Silla-QUEST started science operations in 2009 September. The low redshift supernova survey commenced in 2011 December and is planned to continue for the next 4 years. In this article we describe the instrumentation, software, operation, and performance characteristics of the survey.
Demethylase Activity Is Directed by Histone Acetylation (2001)

Mammalian genomes are compartmentalized into dense inactive chromatin that is hypermethylated and active open chromatin that is hypomethylated. It is generally accepted that this bimodal pattern of methylation is established during development and is then faithfully inherited through subsequent cell divisions by a maintenance DNA methyltransferase (DNMT1). The pattern of methylation is believed to direct local histone acetylation states. In contrast to this well accepted consensus, we show here using a transient transfection model that an active demethylase is involved in shaping patterns of methylation in somatic cells. Demethylase activity is directed by the state of histone acetylation, and therefore, the resulting methylation pattern is determined by local histone acetylation states contrary to the accepted model. Our data support a new model suggesting that the pattern of methylation is maintained by a dynamic balance of methylation and demethylation activities and the local state of histone acetylation. This provides a simple mechanism for explaining why active genes are not methylated.
The activity of sigma E, an Escherichia coli heat-inducible sigma-factor, is modulated by expression of outer membrane proteins. (1993)

sigma E and sigma 32 are two heat- and ethanol-inducible sigma-factors in Escherichia coli. The sigma 32 regulon is also induced by unfolded and misfolded proteins in the cytoplasm, and the function of many of the proteins in the sigma 32 regulon is to bind to cytoplasmic proteins and assist them in folding or unfolding. To further understand the function of the sigma E regulon, we searched for mutants that affected sigma E activity. Our results indicate that a signal generated by expression of outer membrane proteins modulates sigma E activity. Specifically, sigma E activity is induced by increased expression of OMPs and is reduced by decreased expression of OMPs. In addition, mutations that cause misfolded OMPs induce sigma E activity. This signal is generated after the fate of OMPs and periplasmic proteins diverge in the secretory pathway and is not the result of an accumulation of OMP precursors in the cytoplasm. Our results indicate that this effect of OMPs is specific to the sigma E regulon, because none of the above mutations affect sigma 32 activity. We propose that the sigma E regulon is involved in processes that occur in extracytoplasmic compartments and that these two heat-inducible regulons may have distinct but complementary roles of monitoring the state of proteins in the cytoplasm (sigma 32) and outer membrane (sigma E).
Player Adaptive GMM-based Dynamic Game Level Design (2006)

In computer games, the level design and balance of characters are the key features for developing interesting games. Level designers make decision to change the parameters and opponent behaviors in order to avoid the player getting extremely frustrated with the improper level. Generally, opponent behavior is defined by static script, this causes the games to have static difficulty level and static environment. Therefore, it is difficult to keep track of the user playing interest, because a player can easily adapt to changeless repetition. In this paper, we propose a dynamic scripting method that able to maintain the level designers' intention where user enjoys the game by adjusting the opponent behavior while playing the game. The player's countermeasure pattern for dynamic level design is modeled using a Gaussian Mixture Model (GMM). The proposed method is applied to a shooting game, and the experimental results maintain the degree of interest intended by the level designer.
Micropattern of Inorganic Film Prepared by UV-Irradiation and Heat Treatment of Polyalkylsilyne Film (1995)

A micropattern of inorganic thin film was formed by heat treatment of a polyalkylsilyne film at 300° C after UV irradiation with photomask. The Si-Si chain of spin-coated polyalkylsilyne film was photooxidized by UV irradiation with photomask in air. The XPS spectra showed that the Si-O-Si chain of the UV-irradiated part changed into SiO 2 upon heat treatment in vacuo. On the other hand, the heat treatment changed the masked part into an a-Si-like structure with low optical band gap. The micrograph demonstrated lines of the irradiated area and spaces of the masked area.
First Pass Effect (2019)

The first pass effect is a phenomenon in which a drug gets metabolized at a specific location in the body that results in a reduced concentration of the active drug upon reaching its site of action or the systemic circulation. The first pass effect is often associated with the liver, as this is a major site of drug metabolism. However, the first pass effect can also occur in the lungs, vasculature, gastrointestinal tract, and other metabolically active tissues in the body. This effect can become augmented by various factors such as plasma protein concentrations, enzymatic activity, and gastrointestinal motility. The extent to which a patient may experience the first pass effect varies from patient to patient, and this must also be taken into consideration when determining appropriate dosing. If the first-pass effect is exceptionally prominent in a patient, the drug may require administration via a different route to bypass the first-pass effect.
The Resolution of Amino Acids. IV. Lysine<sup>1</sup> (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Resolution of Amino Acids. IV. Lysine1F. J. Kearley and A. W. IngersollCite this: J. Am. Chem. Soc. 1951, 73, 12, 5783–5785Publication Date (Print):December 1, 1951Publication History Published online1 May 2002Published inissue 1 December 1951https://pubs.acs.org/doi/10.1021/ja01156a089https://doi.org/10.1021/ja01156a089research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A key management scheme for wireless sensor networks using deployment knowledge (2004)

To achieve security in wireless sensor networks, it is important to he able to encrypt messages sent among sensor nodes. Keys for encryption purposes must he agreed upon by communicating nodes. Due to resource constraints, achieving such key agreement in wireless sensor networks is nontrivial. Many key agreement schemes used in general networks, such as Diffie-Hellman and public-key based schemes, are not suitable for wireless sensor networks. Pre-distribution of secret keys for all pairs of nodes is not viable due to the large amount of memory used when the network size is large. Recently, a random key pre-distribution scheme and its improvements have been proposed. A common assumption made by these random key pre-distribution schemes is that no deployment knowledge is available. Noticing that in many practical scenarios, certain deployment knowledge may be available a priori, we propose a novel random key pre-distribution scheme that exploits deployment knowledge and avoids unnecessary key assignments. We show that the performance (including connectivity, memory usage, and network resilience against node capture) of sensor networks can he substantially improved with the use of our proposed scheme. The scheme and its detailed performance evaluation are presented in this paper.