gebhart/patrepeval huggingface dataset:
SLA-Aware Provisioning and Scheduling of Cloud Resources for Big Data Analytics (2014)

The stunning growth in data has immensely impacted organizations. Their infrastructure and traditional data management system could not keep up to scale of Big Data. They have to either invest heavily on their infrastructure or move their Big Data analytics to Cloud where they can benefit from both on-demand scalability and contemporary data management techniques. However, to make Cloud hosted Big Data analytics available to wider range of enterprises, we have to carefully capture their preferences in terms of budget and service level objectives. Therefore, this study aims at proposing a SLA and cost-aware resource provisioning and task scheduling approach tailored for Big Data applications in the Cloud. Current approaches assume that data is pre-stored in cluster nodes prior to deployment of Big Data applications. In addition, their focus is purely on task scheduling, and not virtual machine provisioning. We argue that in the Cloud computing context this is not applicable, because the nodes are provisioned dynamically (data cannot be pre-stored) and leaving provisioning to user may lead to under or over provisioning that can both lead to SLA or budget constraint violations. Therefore,in this study we first model the user request, which consist of Big Data analytics jobs with budget and deadline. Then, we model infrastructures as a list of data centers, virtual machines (offered in a pay-as-you-go model), data sources, and network throughputs. After that, to address the aforementioned issues, we propose and compare cost-aware and SLA-based algorithms which provision cloud resources and schedule analytics tasks.
Cerbral Venous Thrombosis in Ulcerative Colitis and Review of the Literature (1991)

A 30‐year‐old man with an eight year history of ulcerative colitis developed left occipital headache, mental confusion, dysphasia and right‐sided weakness when his bowel disease was asymptomatic. Investigations revealed thrombosis of the cerebral sagittal sinus and left transverse sinus. The literature relating to cerebrovascular complications associated with ulcerative colitis is reviewed, and the possible pathogenetic mechanisms of venous thrombosis in ulcerative colitis are discussed. The importance of recognizing that venous thrombosis may occur in association with ulcerative colitis in remission is emphasized.
An on-line fiber drawing tension and diameter measurement device (1989)

A noncontact online drawing tension meter is described. This meter measures both the drawing tension and fiber diameter during the fiber drawing process. Experimental results show that this meter functions satisfactorily in all aspects of testing. The knowledge of online drawing tension not only helps in the manufacture of fibers with low surface tensile stress, but it also gives information about furnace temperature change and the viscosity of the glass at the neck-down region.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Biomimetic Coatings vs. Collagen Sponges as a Carrier for BMP-2: A Comparison of the Osteogenic Responses Triggered In Vivo Using an Ectopic Rat Model (2003)

We have developed a new carrier system for bone morphogenetic protein 2 (BMP-2). This agent has been successfully incorporated into biomimetic calcium phosphate implant coatings without losing its osteoinductive potency. Numerous materials have been tested for their efficiency in carrying BMP-2 and in promoting its osteoinductive effects at both ectopic and orthotopic sites. In the present study, we compare the osteoinductive effects of BMP-2 delivered by biomimetic coatings and by classical collagen sponges in vivo using an ectopic rat model. Titanium-alloy discs, either bearing a co-precipitated layer of calcium phosphate and BMP-2 (1.7 μg/disc) or inserted into collagen sponges impregnated with the same drug (10 μg/sponge), were implanted subcutaneously in the dorsal region of rats and the bone-formation process monitored after 2 and 5 weeks. After 2 weeks, the net volume of bone formed in the biomimetic coating group (5.8 mm3/disc) was greater (p < 0.01) than in the collagen sponge one (2.3 mm3/sponge). By the end of the fifth week, the net volume of bone deposited had increased significantly (p < 0.001) in the biomimetic coating group (11.6 mm3/disc), whereas in the collagen sponge one it remained unchanged. (3.0 mm3/sponge; p = 0.82). As a carrier for BMP-2 and in facilitating its osteogenic effects, biomimetic calcium phosphate coatings offer a distinct advantage over the classical collagen sponge.
NUMERICAL ANALYSIS OF MINIMUM-TIME CORNERING (1994)

This paper investigates minimum-time cornering of a vehicle using numerical simulation based on optimal control theory. It indicates the results of calculations on how to control a vehicle to pass through a certain combined corner with an inclination in minimum time. A Sequential Conjugate Gradient Restoration Algorithm is used to solve the optimal control problem.
Autonomous interpretation of demonstrations for modification of dynamical movement primitives (2017)

The concept of dynamical movement primitives (DMPs) has become popular for modeling of motion, commonly applied to robots. This paper presents a framework that allows a robot operator to adjust DMPs in an intuitive way. Given a generated trajectory with a faulty last part, the operator can use lead-through programming to demonstrate a corrective trajectory. A modified DMP is formed, based on the first part of the faulty trajectory and the last part of the corrective one. A real-time application is presented and verified experimentally.
Identification of Two Essential Glutamic Acid Residues in Glycogen Synthase (2000)

The detailed catalytic mechanism by which glycosyltransferases catalyze the transfer of a glycosyl residue from a donor sugar to an acceptor is not known. Through the multiple alignment of all known eukaryotic glycogen synthases we have found an invariant 17-amino acid stretch enclosed within the most conserved region of the members of this family. This peptide includes an E-X(7)-E motif, which is highly conserved in four families of retaining glycosyltransferases. Site-directed mutagenesis was performed in human muscle glycogen synthase to analyze the roles of the two conserved Glu residues (Glu-510 and Glu-518) of the motif. Proteins were transiently expressed in COS-1 cells as fusions to green fluorescence protein. The E510A and E518A mutant proteins retained the ability to translocate from the nucleus to the cytosol in response to glucose and to bind to intracellular glycogen. Although the E518A variant had approximately 6% of the catalytic activity shown by the green fluorescence protein-human muscle glycogen synthase fusion protein, the E510A mutation inactivated the enzyme. These results led us to conclude that the E-X(7)-E motif is part of the active site of eukaryotic glycogen synthases and that both conserved Glu residues are involved in catalysis. We propose that Glu-510 may function as the nucleophile and Glu-518 as the general acid/base catalyst.
QCAD Simulation and Optimization of Semiconductor Double Quantum Dots (2013)

We present the Quantum Computer Aided Design (QCAD) simulator that targets modeling quantum devices, particularly silicon double quantum dots (DQDs) developed for quantum qubits. The simulator has three di erentiating features: (i) its core contains nonlinear Poisson, e ective mass Schrodinger, and Con guration Interaction solvers that have massively parallel capability for high simulation throughput, and can be run individually or combined self-consistently for 1D/2D/3D quantum devices; (ii) the core solvers show superior convergence even at near-zero-Kelvin temperatures, which is critical for modeling quantum computing devices; (iii) it couples with an optimization engine Dakota that enables optimization of gate voltages in DQDs for multiple desired targets. The Poisson solver includes Maxwell- Boltzmann and Fermi-Dirac statistics, supports Dirichlet, Neumann, interface charge, and Robin boundary conditions, and includes the e ect of dopant incomplete ionization. The solver has shown robust nonlinear convergence even in the milli-Kelvin temperature range, and has been extensively used to quickly obtain the semiclassical electrostatic potential in DQD devices. The self-consistent Schrodinger-Poisson solver has achieved robust and monotonic convergence behavior for 1D/2D/3D quantum devices at very low temperatures by using a predictor-correct iteration scheme. The QCAD simulator enables the calculation of dot-to-gate capacitances, and comparison with experiment and between solvers. It is observed that computed capacitances are in the right ballpark when compared to experiment, and quantum con nement increases capacitance when the number of electrons is xed in a quantum dot. In addition, the coupling of QCAD with Dakota allows to rapidly identify which device layouts are more likely leading to few-electron quantum dots. Very efficient QCAD simulations on a large number of fabricated and proposed Si DQDs have made it possible to provide fast feedback for design comparison and optimization.
High-power lasers (1980)

High-power lasers are defined as systems generating pulses with powers in excess of a few gigawatts. The basic properties common to all such lasers are introduced. Specific high-power lasers are then considered with detailed discussions of neodymium, CO2 and iodine lasers.
Design, Synthesis, and Pharmacological Evaluation of Mefloquine‐Based Ligands as Novel Antituberculosis Agents (2007)

Tuberculosis (TB) is presently regarded as one of the most dangerous infective diseases worldwide and one of the major AIDS-associated infections. To shorten the current treatment regimen, there is an urgent need to identify new anti-TB agents which are active against both replicating TB (R-TB) and nonreplicating TB (NRP-TB). Mefloquine, a well-known antimalarial drug was found to possess reasonable activity against NRP-TB, and accordingly, 30 new analogues were synthesized and evaluated for their anti-TB activity against Mycobacterium tuberculosis H(37)Rv. As the target of mefloquine in Mycobacterium tuberculosis remains unknown, we resorted to modifying mefloquine in a variety of chemically convenient ways, which led us in turn to the active hydrazone 10 a. Further modifications of 10 a led to compound 7 f, with an improved anti-TB activity/selectivity profile with both less cytotoxicity and less predicted CNS side effects compared with mefloquine. The clear structure-activity relationships (SARs) derived from this study should facilitate our ultimate goal of identifying improved anti-TB agents.
Inhibition of Transplant Coronary Arteriosclerosis in Rabbits by Chronic Estradiol Treatment Is Associated With Abolition of MHC Class II Antigen Expression (1996)

Estradiol treatment of cardiac allograft recipients abolishes MHC class II antigen expression in the coronary arteries and decreases macrophage infiltration in all three layers of the vessel wall, whereas T-lymphocyte infiltration is decreased only in the myointima. These findings are associated with estradiol inhibition of myointimal proliferation. Thus, estradiol treatment may have a beneficial effect on graft arteriosclerosis through immune mechanisms.
Beyond expression profiling: Next generation uses of high density oligonucleotide arrays (2003)

In the past decade, microarray technology has become a major tool for high-throughput comprehensive analysis of gene expression, genotyping and resequencing applications. Currently, the most widely employed application of high-density oligonucleotide arrays (HDOAs) involves monitoring changes in gene expression. This application has been carried out in a variety of organisms ranging from Escherichia coli to humans. The recent near completion of the human and mouse genome sequences, however, as well as the genomes of other model experimental species, has allowed for novel applications of HDOAs, such as: the discovery of novel transcripts, mapping functionally important genomic regions and identifying functional domains in RNA molecules. Integrating all this information will provide novel global views of the locations of RNA transcription, DNA replication and the protein nucleic acid interactions that regulate these processes.
Implementation of an object-oriented front-end to a relational database system (2002)

The authors describe the implementation of an object-oriented SQL (structured query language) front-end, called OOSQL, for the IBM DB2 relational database system. The restricted semantic entity-relationship model is used as the data model. The syntax of OOSQL is based on the syntax of SQL, which is the database language for DB2. SQL was chosen as the basis because it is expressive, powerful, and provides an easy evolution for DB2 SQL users. The authors modify and extend SQL by providing object management functions. OOSQL relies on the features of DB2 for dealing with concurrency, transaction management, integrity, and security. OOSQL provides constructors for object definition of any type, including recursive objects and complex objects. A prototype of the front-end described here has been successfully implemented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Silicone Tracheal Cannula (1980)

This presentation is to introduce a silicone tracheal cannula which has been designed for use in selected cases instead of a tracheotomy tube. The design of the cannula was developed in the laboratory and has now been used clinically over a period of four years in 26 cases. Special features of the cannula include a one-size diameter which is suitable for all adults. An inner flange is shaped so as to conform with the inner aspect of the anterior wall of the trachea and to prevent rotation and anterior displacement of the cannula. The inner flange is angulated to allow for proper direction of the long axis of the cannula. An outer flange fits into one of a number of grooves and prevents posterior displacement of the cannula. Thus far the silicone tracheal cannula has been used in cases of sleep apnea, bilateral vocal cord paralysis in the position of adduction, intermittent glottic insufficiency, laryngeal carcinoma, chronic lung disease, and short-term necessity for a tracheotomy. Special equipment has been designed for ease of the surgical procedure required for insertion of the cannula. A one-way valve has been designed which is easily applied to the cannula. A variation of the silicone tracheal cannula has been designed for long-term use.
Sparse probabilistic regression for activity-independent human pose inference (2008)

Discriminative approaches to human pose inference involve mapping visual observations to articulated body configurations. Current probabilistic approaches to learn this mapping have been limited in their ability to handle domains with a large number of activities that require very large training sets. We propose an online probabilistic regression scheme for efficient inference of complex, high- dimensional, and multimodal mappings. Our technique is based on a local mixture of Gaussian processes, where locality is defined based on both appearance and pose, and where the mapping hyperparameters can vary across local neighborhoods to better adapt to specific regions in the pose space. The mixture components are defined online in very small neighborhoods, so learning and inference is extremely efficient. When the mapping is one-to-one, we derive a bound on the approximation error of local regression (vs. global regression) for monotonically decreasing co- variance functions. Our method can determine when training examples are redundant given the rest of the database, and use this criteria for pruning. We report results on synthetic (Poser) and real (Humaneva) pose databases, obtaining fast and accurate pose estimates using training set sizes up to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> .
Regional disaster planning for neonatal intensive care. (2013)

This chapter focuses on developing a resource-based triage tool acceptable to all hospitals in a region and a region-wide approach to surge capacity as disaster planning strategies for neonatal intensive care unit patients.
Tritium Recovery from Liquid Lithium-Lead by Vacuum Degassing (1983)

Various techniques for tritium removal from the liquid eutectic Li17Pb83 under vacuum are considered as candidates for the tritium removal system (TRS) for the Mirror Advanced Reactor Study (MARS). The TRS baseline parameters require the removal of 60% of the tritium contained in the liquid metal at a tritium partial pressure of 1.0 × 10−4 torr (0.013 Pa). Degassing from a droplet spray was chosen as the preferred design option, although removal from thin films is a feasible alternative. Vacuum removal from a stirred pool was rejected because of the size and relatively poor transport conditions. The use of an inert purge gas was also rejected due to the large purge gas flow rate and the problem of separating tritium from a large quantity of inert gas.
Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss (1998)

Guinea-pigs were exposed to a traumatic sound inducing up to 80 dB hearing loss. Beside the well described mechanical damage to outer hair cells, a total disruption of inner hair cell (IHC)-auditory nerve synapses was acutely observed within the traumatized area. To test the hypothesis that synaptic damage is due to an excessive release of glutamate by the IHCs, we examined the protective effect of the glutamate antagonist kynurenate on noise-induced hearing loss. The high degree of protection observed with kynurenate attests that dendritic damage is an important component in noise-induced hearing loss. Moreover, we demonstrate that a synaptic repair mechanism occurring within the first few days post-exposure is partly responsible for the recovery of temporary threshold shifts after an acoustic trauma.
Treatment of Medial and Lateral Epicondylitis—Tennis and Golfer's Elbow—with Low Level Laser Therapy: A Multicenter Double Blind, Placebo-Controlled Clinical Study on 324 Patients (1998)

This clinical study has demonstrated that the best results are obtained using combination treatment (i.e., TPs and scanner technique). Good results are obtained from adequate treatment technique correctly applied, individual energy doses, adequate medical education, clinical experience, and correct approach of laser therapists. We observed that under- and overirradiation dosage can result in the absence of positive therapy effects or even opposite, negative (e.g., inhibitory) effects. The current clinical study provides further evidence of the efficacy of LLLT in the management of lateral and medial epicondylitis.
Circuit driven delay optimization of EMODL carry lookahead adders (2002)

Delay minimization of carry look-ahead adders using the enhanced multiple output domino logic (EMODL), is investigated. Delay versus tree height, using an analytical transistor sizing technique, is analyzed, and the trade-off between the tree height and the number of stages is discussed. Four architectures for a 32-bit adder are compared at the layout level and experiments show that the number of stages is more critical for delay optimization. Mask level simulations predict an aggressive 2.1 ns critical path for the best architecture using a 1.2 micron CMOS technology. The simulation procedure is verified by fabrication.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Immunohistochemical Localization of Endothelin-1 and Endothelin-Converting Enzyme-1 in Rat Lung Allografts (1998)

Chronic rejection is one of the principal factors that lead to development of obliterative bronchiolitis, which is the cause of death for 50% of lung allograft recipients. To more fully comprehend the pathogenesis of chronic rejection, we investigated the expression of endothelin-1 (ET-1) and endothelin-converting enzyme-1 (ECE-1) in inadequately immuno-suppressed rat lung allografts (n = 15) at monthly intervals after transplantation and compared these findings with those in normal rat lung (n = 5), using immunohistochemistry. Throughout the posttransplantation period, inflammatory cells expressed weak to moderate immunoexpression for both peptides. Constant weak to moderate immunoexpression for both peptides was also seen in the alveolar epithelium and neovascularized endothelium. Early after transplantation the vascular endothelium demonstrated strong immunostaining compared with control sections. This immunostaining, however, was reduced to control levels at later stages of rejection. As rejection progressed, staining in the airway epithelium diminished to weak levels as compared with that in controls. These findings suggest a causal role for ET-1 and ECE-1 in the inflammatory and proliferative damage associated with chronic rejection after lung transplantation.
Chitosan Biotinylation and Electrodeposition for Selective Protein Assembly (2008)

An alternative route to protein assembly at surfaces based on using the unique capabilities of biological materials for the spatially selective assembly of proteins is described. Specifically, the stimuli-responsive properties of aminopolysaccharide chitosan are combined with the molecular-recognition capabilities of biotin-streptavidin binding. Biotinylated chitosan retains its stimuli-responsive properties and is capable of electrodepositing at specific electrode addresses. Once deposited, it is capable of binding streptavidin, which can mediate the subsequent assembly of biotinylated proteins. Spatially selective protein assembly using biotinylated Protein A and fluorescently-labeled antibodies is demonstrated.
Catalytic, Asymmetric Synthesis of 1,4‐Benzoxazinones: A Remarkably Enantioselective Route to α‐Amino Acid Derivatives from <i>o</i>‐Benzoquinone Imides (2006)

Cycloaddition of o-benzoquinone imides with chiral ketene enolates derived from cinchona alkaloid catalysts is the basis of a catalytic asymmetric synthesis of 1,4-benzoxazinones and 1,4-benzoxazines. The resulting cycloadducts can be derivatized in situ to provide α-amino acid products in good-to-excellent yields with very high enantioselectivities (see scheme; CAN=ceric ammonium nitrate, Nu=nucleophile).
Polycomb recruitment attenuates retinoic acid–induced transcription of the bivalent NR2F1 gene (2013)

Polycomb proteins play key roles in mediating epigenetic modifications that occur during cell differentiation. The Polycomb repressive complex 2 (PRC2) mediates the tri-methylation of histone H3 lysine 27 (H3K27me3). In this study, we identify a distinguishing feature of two classes of PRC2 target genes, represented by the Nr2F1 (Coup-TF1) and the Hoxa5 gene, respectively. Both genes are transcriptionally activated by all-trans retinoic acid (RA) and display increased levels of the permissive H3K9/K14ac and tri-methylated histone H3 lysine 4 epigenetic marks in response to RA. However, while in response to RA the PRC2 and H3K27me3 marks are greatly decreased at the Hoxa5 promoter, these marks are initially increased at the Nr2F1 promoter. Functional depletion of the essential PRC2 protein Suz12 by short hairpin RNA (shRNA) technology enhanced the RA-associated transcription of Nr2F1, Nr2F2, Meis1, Sox9 and BMP2, but had no effect on the Hoxa5, Hoxa1, Cyp26a1, Cyp26b1 and RARβ2 transcript levels in wild-type embryonic stem cells. We propose that PRC2 recruitment attenuates the RA-associated transcriptional activation of a subset of genes. Such a mechanism would permit the fine-tuning of transcriptional networks during differentiation.