gebhart/patrepeval huggingface dataset:
Key functions for gap junctions in skin and hearing (2011)

Cx (connexin) proteins are components of gap junctions which are aqueous pores that allow intercellular exchange of ions and small molecules. Mutations in Cx genes are linked to a range of human disorders. In the present review we discuss mutations in β-Cx genes encoding Cx26, Cx30, Cx30.3 and Cx31 which lead to skin disease and deafness. Functional studies with Cx proteins have given insights into disease-associated mechanisms and non-gap junctional roles for Cx proteins.
HRM perspectives on addiction to technology and work (2006)

Purpose The aim of this study is an exploration of the behavioural addictions to work (workaholism) and to use of technology (technolophilia), particularly as they overlap in managers' work routines and expectations placed on their employees. Design/methodology/approach The paper presents a qualitative analysis of managers' comments from structured interviews and focus groups in several countries. Findings This research culminated in a model of various adaptations to both work pressure and need to use technology in today's business work, including the potential to over‐adapt or lapse into a pattern of addiction. Research limitations/implications The consolidation of multi‐disciplinary literature and the framework of the model will serve as a reference points for continuing research on behavioural addictions related to work and technology. Practical implications Human resource professionals concerned with employee well‐being can utilize the components of this model to proactively recognize problems and generate remedies. Specific suggestions are offered to offset undesirable adaptations. Originality/value This is the first study to focus on the mutually reinforcing addictions to work and use of technology – an important step forward in recognizing the scope of the issue and generating further research with practical application in business world.
Induction of rabies virus-specific T-helper cells by synthetic peptides that carry dominant T-helper cell epitopes of the viral ribonucleoprotein (1989)

The T-helper cell response to the internal proteins of rabies virus was investigated. The rabies virus nucleoprotein was shown to be a major target antigen for T-helper cells that cross-react between rabies and rabies-related viruses. T-helper cells were assayed in vitro by testing virus-induced lymphocytes for lymphokine secretion in response to antigen. Immunodominant T-helper cell epitopes of the viral nucleoprotein were identified in vitro by using synthetic peptides delineated from the amino acid sequence of the nucleoprotein. The response to synthetic peptides were under Ir gene control. Antigenic peptides were tested in vivo for stimulation of rabies virus-specific T-helper cells. Inoculation of mice with peptides bearing immunodominant T-helper cell epitopes resulted in an accelerated and enhanced neutralizing antibody response upon booster immunization with inactivated rabies virus.
Scaling Human-Object Interaction Recognition Through Zero-Shot Learning (2018)

Recognizing human object interactions (HOI) is an important part of distinguishing the rich variety of human action in the visual world. While recent progress has been made in improving HOI recognition in the fully supervised setting, the space of possible human-object interactions is large and it is impractical to obtain labeled training data for all interactions of interest. In this work, we tackle the challenge of scaling HOI recognition to the long tail of categories through a zero-shot learning approach. We introduce a factorized model for HOI detection that disentangles reasoning on verbs and objects, and at test-time can therefore produce detections for novel verb-object pairs. We present experiments on the recently introduced large-scale HICODET dataset, and show that our model is able to both perform comparably to state-of-the-art in fully-supervised HOI detection, while simultaneously achieving effective zeroshot detection of new HOI categories.
ChemInform Abstract: Thalidomide: From Tragedy to New Drug Discovery (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A new Physical Address Decoder for the Blu-ray Disc System using digital hybrid demodulation techniques (2003)

In this paper, we proposed a new Physical Address Decoder using digital Hybrid demodulation techniques for the Blu-ray Disc System. The proposed new digital MSK demodulation technique and the STW demodulation technique are quite simple to realize compared to the conventional demodulation method. As a result, the hardware complexity of the physical address decoder was greatly reduced. Also, according to the experimental results, the performance of the new Physical Address Decoder proposed in this paper, was proved to be very stable and robust.
COMPARISON OF DIFFERENT ACCELEROMETER CUT POINTS FOR OLDER ADULTS (2014)

COMPARISON OF DIFFERENT ACCELEROMETER CUT POINTS FOR OLDER ADULTS S. Henry, S. Phillips, and C. Papadopoulos Pacific Lutheran University, Tacoma, WA Accelerometers offer detailed minute-by-minute information over extended periods pertaining to physical activity behavior. This information can be used to provide estimates of time spent in different levels of physical activity intensities and overall patterns of physical activity. According to accelerometer data, less than 5% of older adults meet physical activity guidelines making them the least active age group. However, accelerometer cut points to quantify exercise intensity for older adults have been established from research in college-age individuals. Therefore, further examination is needed to determine the most accurate cut-points for physical activity intensity measured by accelerometers for older adults. PURPOSE: The purpose of this study was to more accurately determine the duration of time spent in certain intensities of physical activity when using different accelerometer cut points for an older adult population. METHODS: Forty-two older adults (age: 71.1 ± 20.1 yrs., weight: 70.8 ± 20.0 kg) who participated in exercise classes wore an accelerometer around the waist above the right hip. Accelerometer data were downloaded using 15 second epochs and low frequency extension. In order to quantify exercise intensity, traditional cut points (cpm) of sedentary (≤ 100 cpm), light (101-1952 cpm), and moderate (1952-5724) were used. In addition lower threshold cut points from prior research data in our laboratory (sedentary ≤ 100, light 101-799, and moderate 800 and higher cpm) were applied. Independent t test was used to compare the exercise intensities using the different cut points. Significance was set at p < 0.05. RESULTS: Traditional accelerometer cut points revealed a mean of 31.0 ± 8.3 minutes in sedentary time, 24.3 ± 8.0 minutes in light and 5.2 ± 6.5 minutes in moderate intensity activities. The modified cut points indicated that the participants engaged in 17.1 ± 5.8 minutes of light and 12.3 ± 8.8 minutes of moderate intensity activities. There was a significant difference in minutes participating in light and moderate exercise intensity between the different count thresholds. Furthermore, the majority of the participants (91%) perceived the intensity as moderate. CONCLUSION: These results indicate that using modified cut points for older adults may more closely approximate actual activity level compared to perceived exertion, but further research is warranted.
Binding of sucralfate to duodenal ulcer in man. (1983)

Biopsy specimens of ulcerated and of adjacent non-ulcerated duodenal mucosa were obtained from 17 patients with active duodenal ulcer who had received a single oral dose of 1 g sucralfate. Similar specimens were obtained from 21 patients with a recently healed duodenal ulcer. The specimens were assayed for aluminum to provide an estimate of the amount of sucralfate bound to the mucosa. Sucralfate was present at significantly higher concentrations in ulcerated mucosa than in non-ulcerated mucosa for 6 hr after dosing. In addition, sucralfate was found to bind to healed duodenal ulcers for 6 hr after dosing. This finding provides a rational basis for the use of sucralfate in the maintenance therapy of duodenal ulcer.
The Facioscapulohumeral muscular dystrophy region on 4qter and the homologous locus on 10qter evolved independently under different evolutionary pressure (2007)

The different size distribution and different structure of 10q variant alleles as compared with 4q suggests that these loci evolved in a different manner, since the 4q locus is linked to FSHD, while no inheritable disease is associated with mutations in 10qter genomic region. Hybrid alleles on chromosome 4 always retain a minimum number of 4q type repeats, as they are probably essential for maintaining the structural and functional properties of this subtelomeric region. In addition we found: i) several instances of variant alleles that could be misinterpreted and interfere with a correct diagnosis of FSHD; ii) the presence of borderline alleles in the range of 30-40 kb that carried a qA type telomere and were not associated with the disease.
A Simple Way to Realize the Accurate Detection of Cells' Edge (2011)

Cell edge detection is a basic and important issue in medical image processing, which was crucial to subsequent target feature extraction and object recognition. The traditional methods of image edge detection such as Roberts, Sobel, Prewitt, Laplacian, and Canny, all of which are gradient-based algorithm and are sensitive to noise often cannot locate the edge accuracy. In this paper, the disadvantage of the traditional methods are introduced at first, and then a new mathematical morphological and threshold segmentation edge detection algorithm is proposed to detect the edge of cell image with white noise. In the process, threshold segmentation was used to reduce the effect of noise, and the dilate algorithm was used to extract the boundary. At last compare with the traditional methods. The experimental results show that the new approach is more effective than traditional methods to reduce the impact of noise on test results.
The growth of KClO<sub>3</sub> crystals in the presence of ionic impurities (1932)

Article The growth of KClO3 crystals in the presence of ionic impurities was published on November 1, 1932 in the journal Zeitschrift für Kristallographie - Crystalline Materials (volume 82, issue 1-6).
Entropies, Partitionings and Heart Rate Variability (2009)

Abstract Several definitions of static entropies and coarse-grained entropy rates (CER’s) were used to analyze 24-hour RR interval sequences of three sex, age and disease matched control pairs. The matching was done with the assessment of the risk of cardiac arrest in mind. Details of estimating probability densities (histograms), used to compute the static entropies, have been found crucial to obtain the proper discrimination between the members of control pairs. The effect of signal variance on the entropy estimation is discussed. In a preliminary result, CER’s have been found to yield additional information which may be helpful in discriminating health and pathology.
A WiMedia-Compliant UWB Transceiver in 65nm CMOS (2007)

A UWB transceiver in baseline 65nm CMOS is presented. The chip has an active area of 0.4mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and draws 95mA from a 1.2V supply. It achieves a NF between 5 and 5.5dB over a 3 to 8GHz bandwidth and targets MB-OFDM UWB band groups 1 and 3. The IIP3 of +5dBm and II2 of +24dBm make the design suitable for applications where interferer-robust operation is important.
Diagnosis and clinical signs of feline infectious peritonitis in the central nervous system. (2009)

The diagnosis of feline infectious peritonitis (FIP) in cats remains a challenge in clinical practice. A complete history, physical examination, and adequate selection and interpretation of diagnostic tests remain the cornerstone of antemortem diagnosis. The objective of this review is to familiarize the reader with different aspects of FIP infection of the central nervous system (CNS). This includes signalment, clinical presentation, epidemiology, and diagnostic aids.
Fast method dispatch and effective use of primitives for reified generics in managed X10 (2012)

Two new techniques for improving performance of reified generics without specializing types are presented. With these techniques, the cost of method dispatch is reduced by 95% from the regular self dispatching based implementation, and the cost of returning primitive value is reduced by 15% from the regular boxing based implementation. These techniques are useful to implement reified generics in Java and other JVM languages.
Conservation/Mutation in the Splice Sites of Cytokine ReceptorGenes of Mouse and Human (2013)

Conservation/mutation in the intronic initial and terminal hexanucleotides was studied in 26 orthologous cytokine receptor genes of Mouse and Human. Introns began and ended with the canonical dinucleotides GT and AG, respectively. Identical configurations were found in 57% of the 5' hexanucleotides and 28% of the 3' hexanucleotides. The actual conservation percentages of the individual variable nucleotides at each position in the hexanucleotides were determined, and the theoretical rates of conservation of groups of three nucleotides were calculated under the hypothesis of a mutual evolutionary independence of the neighboring nucleotides (random association). Analysis of the actual conservation of groups of variable nucleotides showed that, at 5', GTGAGx was significantly more expressed and GTAAGx was significantly less expressed, as compared to the random association. At 3', TTTxAG and xTGCAG were overexpressed as compared to a random association. Study of Mouse and Human transcript variants involving the splice sites showed that most variants were not inherited from the common ancestor but emerged during the process of speciation. In some variants the silencing of a terminal hexanucleotide determined skipping of the downstream exon; in other variants the constitutive splicing hexanucleotide was replaced by another potential, in-frame, splicing hexanucleotide, leading to alterations of exon lengths.
Detection of micrometer crack by Brillouin-scattering-based distributed strain and temperature sensor (2008)

A Brillouin-scattering-based distributed strain and temperature sensor (DSTS) has been employed to detect cracks on ceramic by measuring the strain distributions along the surface of the ceramic for the first time. The existence of cracks and their locations are identified by measuring the strain distribution on a sensing fiber bonded on the ceramic surface. Due to innovated design and signal processing, the distributed Brillouin sensor developed for this study achieves a uniquely high resolution and accuracy. Experimental study on ceramic tile specimens demonstrated the efficacy of the distributed Brillouin fiber optic sensor in detecting and locating fine cracks.
Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation (2009)

The development of highly active antiretroviral therapy (HAART) to treat individuals infected with HIV-1 has dramatically improved patient outcomes, but HAART still fails to cure the infection. The latent viral reservoir in resting CD4+ T cells is a major barrier to virus eradication. Elimination of this reservoir requires reactivation of the latent virus. However, strategies for reactivating HIV-1 through nonspecific T cell activation have clinically unacceptable toxicities. We describe here the development of what we believe to be a novel in vitro model of HIV-1 latency that we used to search for compounds that can reverse latency. Human primary CD4+ T cells were transduced with the prosurvival molecule Bcl-2, and the resulting cells were shown to recapitulate the quiescent state of resting CD4+ T cells in vivo. Using this model system, we screened small-molecule libraries and identified a compound that reactivated latent HIV-1 without inducing global T cell activation, 5-hydroxynaphthalene-1,4-dione (5HN). Unlike previously described latency-reversing agents, 5HN activated latent HIV-1 through ROS and NF-kappaB without affecting nuclear factor of activated T cells (NFAT) and PKC, demonstrating that TCR pathways can be dissected and utilized to purge latent virus. Our study expands the number of classes of latency-reversing therapeutics and demonstrates the utility of this in vitro model for finding strategies to eradicate HIV-1 infection.
A method for functional magnetic resonance imaging of olfaction (1997)

A method for generating olfactory stimuli for humans within a functional magnetic resonance imaging (fMRI) experimental design is described. The system incorporates a nasal-mask in which the change from odorant to no-odorant conditions occurs in less than 500 ms and is not accompanied by visual, auditory, tactile, or thermal cues. The mask provides an ordorant-free environment following prolonged ordorant presence. Specific imaging parameters that are conducive to the study of the human olfactory system are described. In a pilot study performed using these methods, the specific patterns of activation observed converged with published experimental and clinical findings.
Open Drug Discovery Teams: A Chemistry Mobile App for Collaboration (2012)

The Open Drug Discovery Teams (ODDT) project provides a mobile app primarily intended as a research topic aggregator of predominantly open science data collected from various sources on the internet. It exists to facilitate interdisciplinary teamwork and to relieve the user from data overload, delivering access to information that is highly relevant and focused on their topic areas of interest. Research topics include areas of chemistry and adjacent molecule-oriented biomedical sciences, with an emphasis on those which are most amenable to open research at present. These include rare and neglected diseases, and precompetitive and public-good initiatives such as green chemistry. The ODDT project uses a free mobile app as user entry point. The app has a magazine-like interface, and server-side infrastructure for hosting chemistry-related data as well as value added services. The project is open to participation from anyone and provides the ability for users to make annotations and assertions, thereby contributing to the collective value of the data to the engaged community. Much of the content is derived from public sources, but the platform is also amenable to commercial data input. The technology could also be readily used in-house by organizations as a research aggregator that could integrate internal and external science and discussion. The infrastructure for the app is currently based upon the Twitter API as a useful proof of concept for a real time source of publicly generated content. This could be extended further by accessing other APIs providing news and data feeds of relevance to a particular area of interest. As the project evolves, social networking features will be developed for organizing participants into teams, with various forms of communication and content management possible.
Host Defense Peptides in the Oral Cavity and the Lung: Similarities and Differences (2008)

Peptides with broad-spectrum antimicrobial activity are found in the mucosal surfaces at many sites in the body, including the airway, the oral cavity, and the digestive tract. Based on their in vitro antimicrobial and other immunomodulatory activities, these host defense peptides have been proposed to play an important role in the innate defense against pathogenic microbial colonization. The genes that encode these peptides are up-regulated by pathogens, further supporting their role in innate immune defense. However, the differences in the local microbial environments between the generally sterile airway and the highly colonized oral cavity suggest a more complex role for these peptides in innate immunity. For example, beta-defensin genes are induced in the airway by all bacteria and Toll-like receptor (TLR) agonists primarily through an NF-kappaB-mediated pathway. In contrast, the same genes are induced in the gingival epithelium by only a subset of bacteria and TLR ligands, via different pathways. Furthermore, the environments into which the peptides are secreted--specifically saliva, gingival crevicular fluid, and airway surface fluid--differ greatly and can effect their respective activities in host defense. In this review, we examine the differences and similarities between host defense peptides in the oral cavity and the airway, to gain a better understanding of their contributions to immunity.
The translation and compatibility of SEQUEL and Query by Example (1976)

The problem of the translation and compatibility of high level data base query languages is addressed via a case study of the languages SEQUEL and Query by Example. In particular, an algorithm for translating queries on a relational data base stated in Query by Example into queries expressed in SEQUEL is introduced. This algorithm is used as a vehicle to describe a consistent interpretation of the semantics of SEQUEL and Query by Example. The compatibility of Query by Example and SEQUEL is briefly discussed. Examples of the operation of the algorithm are presented.
Positioning approach for indoor autonomous mobile robot using a single ultrasonic sensor pair (2013)

This paper presents an approach utilizing asynchronous time-of-flight (ATOF) measurements for autonomous mobile robots (AMRs) to be able to localize itself in indoor environments, using a single ultrasonic sensor pair which comprises an ultrasonic transmitter and an ultrasonic receiver. A circular localization scheme will be described. A state estimation model based on double-layer Kalman filter (DLKF) is developed to fuse the data calculated from ATOF and that from the Dead-Reckoning (DR) localization. A computer simulation experiment has been conducted to verify the efficiency of the proposed localization scheme.
Experimental Demonstration of 128-SP-QAM in Uncompensated Long-Haul Transmission (2013)

We demonstrate 128-SP-QAM experimentally for the first time and compare the performance to PM-16QAM at the same symbol rate (10.5 Gbaud). We find a 1.7 dB increased sensitivity and 50% increased transmission reach over PM-16QAM.