gebhart/patrepeval huggingface dataset:
Comparison between Percutaneous Balloon Valvuloplasty and Open Commissurotomy for Mitral Stenosis (2002)

Eighty patients with tight and pliable mitral stenosis were randomized in a prospective trial comparing percutaneous balloon valvuloplasty and open commissurotomy. Mitral valve area increased significantly in both groups immediately after the procedures. However, a decrease in mitral valve area occurred in both groups at 6, 12 and 24 months during the follow-up. There was no death in either group. Two patients had significant mitral regurgitation after percutaneous balloon valvuloplasty. After 24 months, all patients in the commissurotomy group and 97.4% of the patients in the balloon valvuloplasty group were in New York Heart Association functional class I or II.
Comparison of the effect of live Newcastle disease vaccine Clone 30 in broilers administered at day 1 or at day 7 and the effect of H120 vaccination at 17 days of age: A field experiment (1987)

To analyse the results of a vaccination on the first day of age against Newcastle disease (ND) and on the 17th day of age against Infectious Bronchitis (IB) resp. with spray vaccines with Clone 30 and H120 vaccine. These vaccinations are compared in field circumstances with other vaccination methods. A serological examination and challenge test were used to be informed about the response and protection. From the present study the following conclusions can be drawn: Clear indications are obtained that following a spray vaccination against ND with Clone 30 vaccine of one-day-old broilers which possessed maternal antibodies, birds received a moderately good protection against ND, in spite of very low levels of HI antibodies. A spray vaccination against IB with H120 vaccine of broilers at 17 days of age gave some protection from two weeks after vaccination, however making a good conclusion about the protection is impossible and further investigation is required.
Resting Position Variables at the Shoulder: Evidence to Support a Posture-Impairment Association (2006)

The findings indicate a relationship between posture and pectoralis minor muscle length and support a proposed model linking posture, an anatomical variable, movement dysfunction, and impairment.
A dynamic vision classification system using Fourier descriptions (2002)

The design and implementation of a vision classifier system which can display, label, and identify different known objects in applicable images is presented. Every object can be described during the training phase or classified during the recognition phase according to the normalized Fourier descriptors obtained from sampling its boundary. These descriptors are invariant to the rotation, size, and orientation of the corresponding object. The system allows the user to dynamically train and store new patterns in the appropriate knowledge base of patterns. It is implemented on an AI VAXstation. The descriptors provide an increasingly accurate characterization of shape as more coefficients are included. Each descriptor is a measure of the lobedness of the subject. The descriptors provide accurate classifications for all objects tested under moderate noise and small distortion.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Construction and characterization of hybrid polyomavirus genomes (1986)

Several studies have suggested that certain unique features of the JC virus (JCV) regulatory region are responsible for the restricted lytic and transforming activities of this virus in vitro. To pursue this possibility, we have constructed hybrid polyomavirus genomes by exchanging the regulatory sequences of JCV, BK virus (BKV), and simian virus 40 (SV40). The host range of JCV was not expanded by the substitution of the BKV or SV40 regulatory signals; such hybrids were nonviable even in primary human fetal glial cells, the sole permissive cell for JCV. However, chimeric DNAs containing JCV regulatory sequences and BKV- or SV40-coding sequences were lytically active, indicating that the BKV and SV40 T proteins were capable of effectively interacting with the JCV replication and transcription signals to yield infectious hybrid viruses. Although JCV regulatory sequences and coding sequences both contributed to the restricted lytic activity of this virus, it appears that the latter sequences, most likely hose encoding the T protein, have a greater influence on this behavior.
Spin trapping chemistry of 3,3,5,5-tetramethylpyrroline-<i>N</i>-oxide: an improved cyclic spin trap (1981)

The use of 3,3,5,5-tetramethylpyrroline-N-oxide as a spin trap has been investigated. Spin adducts are found to be more persistent than for 5,5-dimethylpyrroline-N-oxide (DMPO) although the esr spectra are quite similar.
Proline-Catalyzed Asymmetric Addition Reaction of 9-Tosyl-3,4-dihydro-β-carboline with Ketones (2003)

[reaction: see text] 9-Tosyl-3,4-dihydro-beta-carboline (1) reacted with a ketone in the presence of (S)-proline as a catalyst to give the corresponding addition product in good yield and high enantioselectivity. In the process, a small amount of water was found to affect the stereoselectivity of the products. The system was applied to reaction of compound 1 and 3-buten-2-one to give 3,4,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-one, which is a versatile precursor for the synthesis of some indole alkaloids.
Phytochemical genomics in Arabidopsis thaliana: A case study for functional identification of flavonoid biosynthesis genes (2007)

Abstract The completion of the whole genome sequence of Arabidopsis thaliana has made it possible to explore the phytochemical genomics in this species by determining gene-to-metabolite correlation through the comprehensive analysis of metabolite accumulation and gene expression. In this study, flavonoid profiling of wild-type plants and T-DNA insertion mutants was analyzed using ultra-performance liquid chromatography (UPLC)/photodiode array detection (PDA)/electrospray ionization (ESI)/multiple-stage mass spectrometry (MS n ). Detailed analysis of the metabolite changes in the mutants suggested the functions of genes that have been mutated. In silico coexpression analysis of genes involved in flavonoid metabolism in Arabidopsis was performed using a publicly available transcriptome database of DNA microarrays. We inferred a coexpression framework model of the genes involved in the pathways of flavonol, anthocyanin, and proanthocyanidin synthesis, suggesting specific functions and coregulation of the genes of pathway enzymes and transcription factors. The metabolic profiling of the omt1 mutant lacking a methyltransferase gene narrowed down by the coexpression analysis showed that AtOMT1 (At5g54160) is involved not only in the production of lignins and sinapoyl esters but also in the methylation of flavonols forming isorhamnetin. These results suggest that the functional genomics approach by detailed target-metabolite profiling with transcriptome coexpression analysis provides an efficient way of identifying novel gene functions involved in plant metabolism.
<i>Necator americanus</i> in inbred mice: evidence in support of genetically determined differences in the cellular immune response to a primary infection (1997)

The blood and broncho-alveolar leucocyte (BAL) responses, to a primary Necator americanus infection, were studied in male BALB/c and NIH mice. Following percutaneous infection, a significant blood leucocytosis occurred in both the BALB/c and NIH strains. The peak response occurred, in both strains, on day 10 p.i. and this was reflected in the eosinophil response which peaked at the same time-point. The change in blood eosinophil numbers, as a result of infection, was found to be the greatest recorded for any cell type. In BALB/c mice, however, infection elicited a significantly more intense total leucocyte, lymphocyte and eosinophil response than in NIH mice. In contrast, the BAL response was more intense in the NIH strain. Peak BAL responses were observed between days 12 and 16 p.i., in both strains, and the change in broncho-alveolar eosinophil numbers, as a result of infection, was found to be the greatest recorded for any cell type. The relationship between the observed leucocyte responses and resistance to the migrating larvae of a primary infection is discussed.
Crossover frequencies and turn-off time reduction scheme for twisted nematic liquid crystal displays (1974)

The sign change of dielectric anisotropy at the characteristic crossover frequency of a nematic mixture is utilized in twisted nematic liquid crystal displays for turn-off (decay) time reduction. This can be obtained by either (a) a two-frequency addressing or (b) a high-frequency erasing scheme where the high frequency is above the crossover frequency. Data are presented on Eastman Kodak 11900 nematic mixture.
Influence of Coformer Stoichiometric Ratio on Pharmaceutical Cocrystal Dissolution: Three Cocrystals of Carbamazepine/4-Aminobenzoic Acid (2016)

Cocrystallization is a technique to optimize solid forms that shows great potential to improve the solubility of active pharmaceutical ingredients (APIs). In some systems, an API can form cocrystals in multiple stoichiometries with the same coformer. However, it remains unclear how coformer stoichiometry influences solubility. This paper investigates the pharmaceutical:coformer pair carbamazepine (CBZ)/p-aminobenzoic acid (PABA); both CBZ/PABA 1:1 and 2:1 cocrystals are known, and a novel 4:1 CBZ/PABA cocrystal is reported here. The 4:1 cocrystal is structurally characterized, and phase stability data suggest that it is a thermodynamically unstable form. Dissolution experiments show that there is no correlation between the cocrystal stoichiometry and dissolution rate in this system. On the other hand, with the relatively weak intermolecular interactions, metastable forms can be beneficial to dissolution rate, which suggests that more effort should be devoted to cocrystal production with kinetic growth methods.
Nonlinearity-tolerated active noise control using an artificial neural network (2002)

A nonlinearity-tolerated neural active noise control scheme is presented. Time-space patterns are adaptively integrated within its architecture. A learning algorithm with time-delayed memory corresponding to the secondary acoustic paths is adopted. Simulation experiments with a hybrid structure of vibrating radiation and sound in an enclosure are conducted. It is demonstrated that the proposed approach can achieve effective noise attenuation over the whole spectrum of interest, even with a strong nonlinear environment, while the conventional filtered-x LMS active noise controller falls in chaos.
Contour Based Object Tracking (2012)

Contour base Object tracking is an important task in computer vision. The problem involves the tracking of the boundary contour of a moving and deforming object in a sequence of images. Normally the problem is solved as follows.
Satellite Link Simulator Development in 100 MHz Bandwidth to Simulate Satellite Communication Environment in the Geostationary Orbit (2011)

The transponder simulator designed to simulate the transponder of military satellite communication systems in the geostationary orbit is required to have time delay function, because of 250 ms delay time, when a radio wave transmits the distance of 36,000 km in free space. But, it is very difficult to develop 250 ms time delay device in the transponder simulator of 100 MHz bandwidth, due to unstable operation of FPGA, loss of memory data for the high speed rate signal processing. Up to date, bandwidth of the time delay device is limited to 45 MHz bandwidth. To solve this problem, we propose the new time delay techniques up to 100 MHz bandwidth without data loss. Proposed techniques are the low speed down scaling and high speed up scaling methods to read and write the external memory, and the matrix structure design of FPGA memory to treat data as high speed rate. We developed the satellite link simulator in 100 MHz bandwidth using the proposed new time delay techniques, implemented to the transponder simulator and verified the function of 265 ms time delay device in 100 MHz bandwidth.
Wavelet for speech denoising (2002)

This paper presents the use of the wavelet transform for noise reduction in noisy speech signals. The use of different wavelets and different orders have been evaluated for their suitability as a transform for speech noise removal. The wavelets evaluated are the biorthogonal wavelets, Daubechies wavelets, coiflets as well as symlets. Also two different means of filtering the noise in the transformed coefficients are presented. The first method is based on magnitude subtraction while the second method is based on the Wiener filter with a priori signal to noise ratio estimation.
Spar buoy platform for water wave, turbulence and underwater electric field sensors (2011)

During the summer of 2010 the US Navy's Center for Innovation in Ship Design (CISD) at the Naval Surface Warfare Center Carderock Division (NSWCCD) supported three interns to work at the Navy's South Florida Ocean Measurement Facility (SFOMF). For these summer internships, funding was provided by the Naval Research Enterprise Intern Program (NREIP). NREIP, sponsored by the Office of Naval Research, allows college students to experience a 10-week internship relevant to their science and engineering major. The program provides students exposure to the everyday practice of engineering and research at DOD laboratories across the country. The Florida Atlantic University Department of Ocean Engineering interns worked in a team to tackle an ocean engineering buoy design and technology project.
A. Palmgren Revisited-A Basis for Bearing Life Prediction (1997)

The world has gone through the critical phase of SARS-CoV-2 crisis caused by the new variants of the virus. The globally concerted effort to characterize viral genomic mutations across different clades has revealed several changes in the coding and also non-coding regions which might lead to a violent presentation or re-infection occurrence. Here, we studied a COVID-19 subject who represented the symptoms following the full recovery of the first infection. COVID-19 specific IgM and IgG were evaluated in both steps. The viral samples from oropharyngeal/nasopharyngeal were subjected to RT-PCR and full sequencing was done in both incidences. The sequencing data was fully investigated with the reference sequence of SARS-CoV-2 and the changes were detected. The obtained data is in favor of re-infection with 128 days of interval. SARS-CoV-2 presented more severely in the second episode of the disease and the specific antibodies against COVID-19 were not detectable. Both infections were caused by the same clade 20G, however, the mutation rates were higher in the second incidence including 10 nucleotide substitutions which had rarely been reported before. In the present study, the nucleotide mutations in various regions of the viral genome have been presented. The re-infection could have significant effect on clinical implications as well as vaccination.
1.5 μm tunable wavelength filter with wide tuning range and high constant gain using a phase-controlled distributed feedback laser diode (1988)

We demonstrate a 1.5 μm tunable wavelength filter which uses a phase-controlled distributed feedback laser diode. Tuning range as wide as 43 GHz (3.4 Å) with 27 dB constant gain has been achieved. A five-channel wavelength selection with less than −10 dB crosstalk is expected with this filter.
A powerful tool for dynamic simulation of unbalanced phenomena (1997)

EUROSTAG is a professional grade time domain simulation software jointly developed by Electricite de France and Tractebel. It simulates, with a variable time step strategy, the dynamics of power systems, from transient phenomena to long term dynamics. Great attention has always been paid in the software developments to user-friendliness and performance in terms of accuracy and low computation times. These are in fact key ingredients for making power system simulation studies easier, faster, and more reliable. Introduction of unbalanced phenomena has been done in the latest version of the software in an original and efficient way, keeping this philosophy in mind. The goal of this paper is to present this development and its validation.
Penicillin-binding proteins in bacteria (1980)

The penicilllin-binding proteins (PBPs) of several gram-positive and gram-negative bacteria have been examined. The results indicate that: (i) PBPs are membrane proteins with molecular weights ranging from 40,000 to 120,000. When extracted with Triton X-100 from sonicated cells, they appear to fall into two patterns: one found in rods and the other in spheres. A major difference is in the low-molecular-weight component, which is usually the major PBP in bacilli but a minor one in cocci. (ii) There is a wide variation in both the number and the amount of PBPs in different bacteria, and taxonomically related bacteria tend to have similar PBP patterns. These patterns often correlate with the affinity of PBPs for penicillin and other beta-lactam antibiotics. (iii) The low-molecular-weight component usually releases penicillin spontaneously with a half-life of 10 min or less. Most, but not all, PBPs release bound penicillin in the presence of neutral hydroxylamine (0.2 to 0.8 M).
WNT5A is epigenetically silenced in hematologic malignancies and inhibits leukemia cell growth as a tumor suppressor (2007)

To the editor:

Aberrant activation of the Wnt/β-catenin signaling pathway is a hallmark of cancers.[1][1],[2][2] A recent Blood report showed the down-regulation of multiple Wnt-signaling inhibitors including SFRPs, WIF1 , DKK3 , and DACT1 in acute lymphoblastic leukemia (ALL) cell lines and
Coordinated multi point transmission in 3GPP LTE heterogeneous networks (2012)

This paper summarizes coordinated multi point transmission (CoMP) operation in heterogeneous network deployments. Such scenarios have recently attracted significant attention in 3GPP where an ongoing work item is scheduled to be completed in the LTE Release 11 timeframe. An important focus of this paper is to analyze both the CoMP schemes and the deployment architectures that have been considered in 3GPP. We provide a detailed comparison of benefits and drawbacks for both based on system-level evaluations. Further, CoMP is compared against an eICIC performance baseline which does not rely on tight coordination as in the case of CoMP.
Ultrafast wide range all-optical switch using complex refractive-index changes in a composite film of silver and polymer containing photochromic dye (1998)

An all-optical ultrafast switch which operates at a wide wavelength range has been demonstrated based on photoinduced changes of real and/or imaginary parts of complex refractive index in a composite thin film of silver and polymer containing photochromic spiropyran dye. Very fast switching ON and OFF of a reading beam within 20 ns in a 400–800 nm range was achieved at the incident angle of guided-wave mode using a photochromic spiropyran-doped polystyrene thin film and a ns pulsed UV or visible laser as a writing beam. These responses were caused by the changes of complex refractive index due to photochromism. No applied power was required to hold the switched state. An image was also written to the probe beam by irradiation through a pattern.
HCC Development Is Associated to Peripheral Insulin Resistance in a Mouse Model of NASH (2014)

the CDAA model promotes the development of HCC from NAFLD-NASH in the presence of insulin resistance but in the absence of cirrhosis. Since this condition is increasingly recognized in humans, our study provides a model that may help understanding mechanisms of carcinogenesis in NAFLD.
Update propagation in distributed memory hierarchy (2002)

A distributed memory hierarchy (DMH) is a memory system consisting of storage modules distributed over a high-bandwidth local area network. It provides for transaction applications an abstraction of single virtual memory space to which shared data are mapped. As in a conventional memory hierarchy (MH) in a single-machine system, a DMH is responsible for locating, migrating, and caching data pages; however, unlike a conventional MH, a DMH must do so across the storage modules in a network. In addition, a DMH must handle the problem of propagation of transaction updates preserving serializability of transactions. The performance of a DMH system is strongly influenced by concurrency control and update propagation. It is also crucial that performance analysis accounts for memory resources and network requirements. A DMH system is presented, the tradeoffs between conservative and aggressive update propagation strategies are defined, and promising new strategies are identified.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Tumor vaccination with macrophage colony-stimulating factor-producing Lewis lung carcinoma in mice (1996)

Expression of various cytokines by cytokine gene-transduced tumor cells has been shown to increase antitumor immunity of tumor-bearing hosts. In the present study, macrophage-colony stimulating factor (M-CSF) cDNA was retrovirally transfected into Lewis lung carcinoma cells (3LL) of C57BL/6 mouse origin, and the effects of M-CSF expression were studied by inoculating syngeneic C57BL/6 mice with M-CSF-expressing 3LL cells. The mice inoculated with the lowest M-CSF-producing 3LL clone showed significant prolongation of the survival compared with wild-type 3LL- Inoculated mice, and 70% or more of the mice inoculated with 3LL clones with higher M-CSF production rejected inoculation. Mice injected with radiation-inactivated M-CSF-expressing 3LL cells before or after Inoculation of wild-type 3LL cells showed prolonged survival compared with mice injected with radiated control 3LL cells before or after transplantation of wild-type cells. In vivo depletion of effector subpopulations by injection of antibodies against CD4+ T cells, CD8+ T cells, or natural killer (NK) cells suggested involvement of NK cells and CD4+ T cells in M-CSF-mediated antitumor cytotoxicity in M-CSF- producing 3LL cells-inoculated mice. Severe combined immunodeficiency (SCID) mice with defective T- and B-cell function showed prolonged survival duration after inoculation with M-CSF-expressing 3LL cells compared with those transplanted with control 3LL cells, and this effect of M-CSF expression by 3LL-cells in SCID mice was also abolished by in vivo depletion of NK cells by antibody injection. These findings together with the previous reports that M-CSF augments antibody- dependent and-independent antitumor cytotoxicity suggest that M-CSF induces tumor immunity in this cytokine-expressing tumor- transplantation model.