gebhart/patrepeval huggingface dataset:
Lack of hypotensive and brain catecholamine depleting effects by erythro- and threo-alpha-methyl DOPS. (1979)

An investigation was carried out to ascertain whether erythro- and threo-alpha-methyl-dihydroxy-phenyl-serine were able of depleting cerebral and peripheral norepinephrine (NE) through their metabolization to alpha-mNE. The results show that the alpha-methyl-aminoacids were decarboxylated only at the periphery and that the threo-form caused depletion in cardiac NE. In any case, both isomers were unable to cross the blood-brain barrier leaving the cerebral NE unaffected. Consequently the use of alpha-mDOPS as alternative tool to alpha-mDOPA in the therapy for hypertension seems unlikely to occur. The results also provide evidence for differences in the pharmacokinetics of the two isomers.
Performance of multilayer vapor-phase epitaxial complementary silicon millimeter-wave IMPATT diodes (1973)

Recent results obtained on silicon complementary (N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> PP <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> ) IMPATT oscillators will be presented. Output power of 700 mW at 9.1% efficiency has been achieved at 30 GHz in a tunable disc cavity circuit. Measured FM noise parameter, M, of P-type diodes was found to be 3-dB less than measured value of M for N-type diodes.
The relationship between strategy and entrepreneurship (1995)

Proposes primarily to test empirically Smith′s entrepreneurial typology and Miles and Snow′s typology of strategy in the restaurant sector, and then to establish whether or not there is a relationship between type of entrepreneur and type of strategy. Evidence suggests that Smith′s two entrepreneurial types may not be mutually exclusive and that a third group of entrepreneurs exists combining characteristics from both Smith′s craftsmen and opportunistic types. Finds support for Miles and Snow′s four generic strategies of defender, prospector, analyser and reactor. Through the use of discriminant analysis, it was possible to demonstrate a relationship between type of entrepreneur and type of strategy.
Rodent Herpesvirus Peru Encodes a Secreted Chemokine Decoy Receptor (2013)

Viruses have long been studied not only for their pathology and associated disease but also as model systems for understanding cellular and immunological processes. Rodent herpesvirus Peru (RHVP) is a recently characterized rhadinovirus related to murine gammaherpesvirus 68 (MHV68) and Kaposi's sarcoma-associated herpesvirus (KSHV) that establishes acute and latent infection in laboratory mice. RHVP encodes numerous unique proteins that we hypothesize might facilitate host immune evasion during infection. We report here that open reading frame (ORF) R17 encodes a high-affinity chemokine binding protein that broadly recognizes human and murine CC and C chemokines. The interaction of R17 with chemokines is generally characterized by rapid association kinetics, and in the case of CCL3, CCL4, CCL5, CCL24, and XCL1, extremely stable complexes are formed. Functionally, R17 potently inhibited CCL2-driven chemotaxis of the human monocytic cell line THP-1, CCL3-driven chemotaxis of peripheral blood mononuclear cells, and CCL2-mediated calcium flux. Our studies also reveal that R17 binds to glycosaminoglycans (GAGs) in a process dependent upon two BBXB motifs and that chemokine and GAG binding can occur simultaneously at distinct sites. Collectively, these studies suggest that R17 may play a role in RHVP immune evasion through the targeted sabotage of chemokine-mediated immune surveillance.
ELECTRICALLY CONDUCTIVE POLYMER-POLYMER COMPOSITES (1983)

Conductive composites have been prepared by polymerization of acelene in polyethylene films followed by iodine doping. The attainment of high conductivity (5-10 S/cm) at low (CH)x concentrations (∼3 wt%) is explained with a simple percolation model.
Aleitamento materno na primeira hora de vida em um Hospital Amigo da Criança: prevalência, fatores associados e razões para sua não ocorrência (2014)

Objetivos: identificar a prevalência do aleitamento materno na primeira hora de vida, os fatores associados e as razões para sua não ocorrência em um Hospital Amigo da Criança. Métodos: estudo transversal com 562 mães e recém-nascidos. Os dados foram obtidos entre outubro a novembro de 2011 mediante formulários de entrevista e consulta a prontuários. Modelo de Poisson foi ajustado para analisar a prevalência do aleitamento materno na primeira hora de vida em função das variáveis de exposição. Resultados: a prevalência do aleitamento materno na primeira hora de vida foi de 31%. Apenas o parto normal permaneceu no modelo final, apresentando razão de prevalência de 27% a mais em relação ao parto cesáreo (p=0,020). As razões para que 388 crianças não tenham sido amamentadas na primeira hora de vida foram classificadas em: problemas de saúde da criança (328, 84,5%), da mãe (241, 62,1%) e atraso no resultado do teste rápido anti-HIV (199, 51,2%), 11 (2,8%) não apresentaram nenhuma justificativa. Conclusões: os resultados relatados ainda estão bem abaixo das recomendações da Organização Mundial da Saúde (OMS), o que em grande parte pode ser atribuído às condições próprias de um hospital de nível terciário, cuja demanda é constituída predominantemente por casos de pacientes de médio e elevado risco obstétrico.
A New Microcomputer-Controlled Neutron Activation and Analysis System (1990)

A microcomputer-controlled irradiation and measurement system and a microprocessor-controlled sample changer have been installed at the SLOWPOKE-2 Facility at the Royal Military College of Canada (RMC). These systems can provide the gamut of instrumental neutron activation analysis (INAA) techniques for the analyst. Custom software has been created for system control, data acquisition, and off-line spectral analysis using programs that incorporate Gaussian peak-fitting methods of analysis. The design and use of the equipment is discussed, and the performance Is Illustrated with results obtained from the analysis of marine sediment and biological reference materials.
The Analysis of Traffic Flow Model (2013)

With worsening traffic condition in large and medium-sized cities, it has become one of the most important steps for the urban traffic strategy to solve the traffic problems. Since the urban traffic is a complex system in various factors and huge scale, to establish related mathematical model through computer numerical simulation is a significant solution to the comprehensive problems of complex analysis, decision and planning. At present researches on the problems have been achieved in many foreign countries, but domestic research is not enough, especially in the practical application. The macroscopic traffic flow model and microscopic traffic flow model are described and cellular automaton model, dual channel decision model and car-following model are analyzed in this paper, prediction of the ideal traffic flow and trip distribution is consequently concluded, which deepen the understanding to the traffic flow of various phenomenon intrinsic mechanism and predict most closely to the actual situation of traffic flow, which can make fundamental work for traffic flow simulation and for real-time traffic control [1-3] .
Conversion of Functional Group on PTFE Surface by Argon Plasma Pre-treatment and Polydopamine Coating (2018)

The mussel-inspired polydopamine (PDA) coating, which is unstable and fragile on poly(tetrafluoroethylene) (PTFE) surface, is now successfully stabilized by using argon plasma treatment as a pre-treatment before conducting PDA coating. In this study, the parameters of plasma including plasma energies, gas pressures and treating time were adjusted to construct a stable PDA coating layer on PTFE surface. Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy were used to characterize the surfaces. The sonication stability of PDA coating layer on plasma treated PTFE surface was evaluated. The robust PDA coating layer reported in this study can act as a reactive platform for further modification and reaction on PTFE.
Automatic differentiation in machine learning: a survey (2015)

Derivatives, mostly in the form of gradients and Hessians, are ubiquitous in machine learning. Automatic differentiation (AD), also called algorithmic differentiation or simply "autodiff", is a family of techniques similar to but more general than backpropagation for efficiently and accurately evaluating derivatives of numeric functions expressed as computer programs. AD is a small but established field with applications in areas including computational fluid dynamics, atmospheric sciences, and engineering design optimization. Until very recently, the fields of machine learning and AD have largely been unaware of each other and, in some cases, have independently discovered each other's results. Despite its relevance, general-purpose AD has been missing from the machine learning toolbox, a situation slowly changing with its ongoing adoption under the names "dynamic computational graphs" and "differentiable programming". We survey the intersection of AD and machine learning, cover applications where AD has direct relevance, and address the main implementation techniques. By precisely defining the main differentiation techniques and their interrelationships, we aim to bring clarity to the usage of the terms "autodiff", "automatic differentiation", and "symbolic differentiation" as these are encountered more and more in machine learning settings.
A color vision system for peach grading (1988)

ABSTRACT Acolor computer vision system was developed to inspect and grade fresh market peaches. System components included a color solid-state television camera, frame grabber, interface circuitry, and microcomputer. Digital color images of peaches were acquired as the fruit moved on a belt conveyor through an illumination chamber. Image analysis algorithms were developed to compare peach ground color to reference peach maturity colors, and to estimate the amount of blushed surface area. Ground color maturity classification with the computer vision system agreed with manual maturity classification in 54% of the test samples, and was within one color standard in 88% of the samples. Correlation coefficient between machine and manual estimates of blush surface area was 0.92.
Experimental study on control of performance of the cuttings re-injection slurry (2010)

This paper confirms the performance standard of cuttings re-injection slurry based on the information of the cuttings re-injection operation abroad.The influence of the added cuttings dosage on the performance of re-injection slurry is analyzed by experiments.The reasonable treating formula of re-injection slurry is provided.
Determination of gas temperature from unresolved bands in the spectrum from a nitrogen discharge (1976)

A spectroscopic technique is described for determining the gas temperature associated with unresolved bands in the second positive system of the emission spectrum of molecular nitrogen. Projection operators are used in an iterative technique to estimate gas temperature from the shape of a band. The technique is applied to temporally resolved spectra recorded during the glow stage of spark breakdown in nitrogen. The gas temperature is shown to rise from about room temperature at a rate that is in agreement with the electrical power input to the glow discharge. This technique could be of use for studying the effect of gas temperature on the performance of the nitrogen laser.
A novel trench Schottky rectifier structure with controlled conductivity modulation (2014)

A Trench MOS Barrier Schottky rectifier (TMBS) structure with a novel conductivity modulation scheme has been presented. The conductivity modulation in the structure is achieved by using remote conductivity modulation (RCM) centers in the mesa regions, with varying frequency and doping profiles to achieve the desired trade-off between forward voltage drop and switching speed of the device. Using the new modulation scheme, devices with low forward voltage drop or low switching speeds can be obtained without the need for any lifetime control in the drift region. The RCM scheme has been implemented in a 200 V, 30 A trench Schottky device, and it has been demonstrated experimentally that by employing the RCM scheme, best-in-class forward voltage drop, breakdown voltage and switching speed are achieved.
Fermi-level depinning for low-barrier Schottky source/drain transistors (2006)

By imposing an ultrathin insulator between low-work function metals and silicon, the Schottky barrier of the junction can be substantially reduced, decreasing junction resistance. With this approach, low-Schottky-barrier metal source/drain (S/D) transistors with Mg and Yb as S/D metals are demonstrated.
R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis (2008)

Herein, we demonstrate that Lrp6-mediated R-spondin 2 signaling through the canonical Wnt pathway is required for normal morphogenesis of the respiratory tract and limbs. We show that the footless insertional mutation creates a severe hypomorphic R-spondin 2 allele (Rspo2(Tg)). The predicted protein encoded by Rspo2(Tg) neither bound the cell surface nor activated the canonical Wnt signaling reporter TOPFLASH. Rspo2 activation of TOPFLASH was dependent upon the second EGF-like repeat of Lrp6. Rspo2(Tg/Tg) mice had severe malformations of laryngeal-tracheal cartilages, limbs and palate, and lung hypoplasia consistent with sites of Rspo2 expression. Rspo2(Tg/Tg) lung defects were associated with reduced branching, a reduction in TOPGAL reporter activity, and reduced expression of the downstream Wnt target Irx3. Interbreeding the Rspo2(Tg) and Lrp6(-) alleles resulted in more severe defects consisting of marked lung hypoplasia and absence of tracheal-bronchial rings, laryngeal structures and all limb skeletal elements.
Morphological Stability and Performance of Polymer–Fullerene Solar Cells under Thermal Stress: The Impact of Photoinduced PC<sub>60</sub>BM Oligomerization (2014)

We report a general light processing strategy for organic solar cells (OSC) that exploits the propensity of the fullerene derivative PC60BM to photo-oligomerize, which is capable of both stabilizing the polymer:PC60BM active layer morphology and enhancing the device stability under thermal annealing. The observations hold for blends of PC60BM with an array of benchmark donor polymer systems, including P3HT, DPP-TT-T, PTB7, and PCDTBT. The morphology and kinetics of the thermally induced PC60BM crystallization within the blend films are investigated as a function of substrate and temperature. PC60BM nucleation rates on SiOx substrates exhibit a pronounced peak profile with temperature, whose maximum is polymer and blend-composition dependent. Modest illumination (<10 mW/cm(2)) significantly suppresses nucleation, which is quantified as function of dose, but does not affect crystalline shape or growth, in the micrometer range. On PEDOT:PSS substrates, thermally induced PC60BM aggregation is observed on smaller (≈ 100 nm) length scales, depending upon donor polymer, and also suppressed by light exposure. The concurrent thermal dissociation process of PC60BM oligomers in blend films is also investigated and the activation energy of the fullerene-fullerene bond is estimated to be 0.96 ± 0.04 eV. Following light processing, the thermal stability, and thus lifetime, of PCDTBT:PC60BM devices increases for annealing times up to 150 h. In contrast, PCDTBT:PC70BM OSCs are found to be largely light insensitive. The results are rationalized in terms of the suppression of PC60BM micro- and nanoscopic crystallization processes upon thermal annealing caused by photoinduced PC60BM oligomerization.
A flexible pragmatics-driven language generator for animated agents (2003)

This paper describes the NECA MNLG; a fully implemented Multimodal Natural Language Generation module. The MNLG is deployed as part of the NECA system which generates dialogues between animated agents. The generation module supports the seamless integration of full grammar rules, templates and canned text. The generator takes input which allows for the specification of syntactic, semantic and pragmatic constraints on the output.
A Functional –1 Ribosomal Frameshift Signal in the Human Paraneoplastic Ma3 Gene (2006)

A bioinformatics approach to finding new cases of -1 frameshifting in the expression of human genes revealed a classical retrovirus-like heptanucleotide shift site followed by a potential structural stimulator in the paraneoplastic antigen Ma3 and Ma5 genes. Analysis of the sequence 3' of the shift site demonstrated that an RNA pseudoknot in Ma3 is important for promoting efficient -1 frame-shifting. Ma3 is a member of a family of six genes in humans whose protein products contain homology to retroviral Gag proteins. The -1 frameshift site and pseudoknot structure are conserved in other mammals, but there are some sequence differences. Although the functions of the Ma genes are unknown, the serious neurological effects of ectopic expression in tumor cells indicate their importance in the brain.
Speech Technology in Computer-Assisted Language Learning: Strengths and Limitations of a New CALL Paradigm. (1998)

We investigate the suitability of deploying speech technology in computer-based systems that can be used to teach foreign language skills. In reviewing the current state of speech recognition and speech processing technology and by examining a number of voice-interactive CALL applications, we suggest how to create robust interactive learning environments that exploit the strengths of speech technology while working around its limitations. In the conclusion, we draw on our review of these applications to identify directions of future research that might improve both the design and the overall performance of voice-interactive CALL systems.
Hierarchical Composite Membranes with Robust Omniphobic Surface Using Layer-By-Layer Assembly Technique (2018)

In this study, composite membranes were fabricated via layer-by-layer (LBL) assembly of negatively charged silica aerogel (SiA) and 1H,1H,2H,2H-perfluorodecyltriethoxysilane (FTCS) on a polyvinylidene fluoride phase inversion membrane and interconnecting them with positively charged poly(diallyldimethylammonium chloride) (PDDA) via electrostatic interaction. The results showed that the PDDA-SiA-FTCS coated membrane had significantly enhanced the membrane structure and properties. New trifluoromethyl and tetrafluoroethylene bonds appeared at the surface of the coated membrane, which led to lower surface free energy of the composite membrane. Additionally, the LBL membrane showed increased surface roughness. The improved structure and property gave the LBL membrane an omniphobic property, as indicated by its good wetting resistance. The membrane performed a stable air gap membrane distillation (AGMD) flux of 11.22 L/m<sup>2</sup> h with very high salt rejection using reverse osmosis brine from coal seam gas produced water as feed with the addition of up to 0.5 mM SDS solution. This performance was much better compared to those of the neat membrane. The present study suggests that the enhanced membrane properties with good omniphobicity via LBL assembly make the porous membranes suitable for long-term AGMD operation with stable permeation flux when treating challenging saline wastewater containing low surface tension organic contaminants.
Sensitivity enhanced nanothermal sensors for photoacoustic temperature mapping (2013)

Photoacoustic imaging can be used to guide and validate the therapeutic outcome of nanoparticle-mediated photothermal therapy through its ability to visualize the delivery of nanoparticle contrast agents, image the temperature distribution inside living tissue, and confirm tissue coagulation. In this image-guided process, temperature mapping plays a critical role for thermal dosage control. Therefore, developing a sensitive and accurate photoacoustic technique to quantitatively measure the temperature distribution during thermal therapy is essential. In this study, we investigated and demonstrated that silica-coated gold nanorods, can provide a multi-fold improvement in sensitivity of the photoacoustic temperature mapping compared to gold nanorods without silica coating, and serve as a nanothermal sensor to accurately and quantitatively visualize temperature distributions during photothermal therapy.
High-throughput trapping of secretory pathway genes in mouse embryonic stem cells (2006)

High-throughput gene trapping is a random approach for inducing insertional mutations across the mouse genome. This approach uses gene trap vectors that simultaneously inactivate and report the expression of the trapped gene at the insertion site, and provide a DNA tag for the rapid identification of the disrupted gene. Gene trapping has been used by both public and private institutions to produce libraries of embryonic stem (ES) cells harboring mutations in single genes. Presently, approximately 66% of the protein coding genes in the mouse genome have been disrupted by gene trap insertions. Among these, however, genes encoding signal peptides or transmembrane domains (secretory genes) are underrepresented because they are not susceptible to conventional trapping methods. Here, we describe a high-throughput gene trapping strategy that effectively targets secretory genes. We used this strategy to assemble a library of ES cells harboring mutations in 716 unique secretory genes, of which 61% were not trapped by conventional trapping, indicating that the two strategies are complementary. The trapped ES cell lines, which can be ordered from the International Gene Trap Consortium (http://www.genetrap.org), are freely available to the scientific community.
Learning to Paraphrase: An Unsupervised Approach Using Multiple-Sequence Alignment (2003)

We address the text-to-text generation problem of sentence-level paraphrasing -- a phenomenon distinct from and more difficult than word- or phrase-level paraphrasing. Our approach applies multiple-sequence alignment to sentences gathered from unannotated comparable corpora: it learns a set of paraphrasing patterns represented by word lattice pairs and automatically determines how to apply these patterns to rewrite new sentences. The results of our evaluation experiments show that the system derives accurate paraphrases, outperforming baseline systems.
Production and Ecological Significance of Yeast Cell Wall-Degrading Enzymes from Oerskovia (1978)

Motile actinomycetes capable of degrading walls of viable yeast cells were isolated from soil and identified as Oerskovia xanthineolytica. A lytic assay based on susceptibility of enzyme-treated cells to osmotic shock was developed, and 10 of 15 strains of O. xanthineolytica, Oerskovia turbata, and nonmotile Oerskovia- like organisms from other collections were found to possess yeast lytic activities. All lytic strains produced laminaranase and alpha-mannanase, but the amounts, determined by reducing group assays, were not proportional to the observed lytic activities. The Oerskovia isolates demonstrated chemotactic, predatory activity against various yeast strains and killed yeasts in mixed cultures. Of 15 carbon sources tested for production of lytic enzyme, purified yeast cell walls elicited the highest activity. Glucose repressed enzyme production and caused cells to remain in the microfilamentous and motile rod stages of the Oerskovia cell cycle. Crude lytic activity was optimal at pH 5.6 to 7.0 and inactivated by heating for 6 min at 50 degrees C. Partial purification by isoelectric focusing showed that all lytic activity was associated with four beta-(1-->3)-glucanases. The absence of protein disulfide reductase, N-acetyl-beta-d-hexosaminidase, and phosphomannanase in crude preparations indicated that the principal enzyme responsible for yeast wall lysis was a beta-(1-->3)-glucanase that produced relatively little reducing sugar from yeast glucan.