gebhart/patrepeval huggingface dataset:
Handling Noise in Single Image Deblurring Using Directional Filters (2013)

State-of-the-art single image deblurring techniques are sensitive to image noise. Even a small amount of noise, which is inevitable in low-light conditions, can degrade the quality of blur kernel estimation dramatically. The recent approach of Tai and Lin [17] tries to iteratively denoise and deblur a blurry and noisy image. However, as we show in this work, directly applying image denoising methods often partially damages the blur information that is extracted from the input image, leading to biased kernel estimation. We propose a new method for handling noise in blind image deconvolution based on new theoretical and practical insights. Our key observation is that applying a directional low-pass filter to the input image greatly reduces the noise level, while preserving the blur information in the orthogonal direction to the filter. Based on this observation, our method applies a series of directional filters at different orientations to the input image, and estimates an accurate Radon transform of the blur kernel from each filtered image. Finally, we reconstruct the blur kernel using inverse Radon transform. Experimental results on synthetic and real data show that our algorithm achieves higher quality results than previous approaches on blurry and noisy images.
Hexosaminidase isozyme in type O Gm2 gangliosidosis (Sandhoff-Jatzkewitz disease). (1975)

The residual enzyme of the fibroblasts of a child with homozygous type 0 GM2 gangliosidosis (Sandhoff-Jatzkewitz disease) has been found to correspond with a minor fraction of enzyme which can be isolated from normal fibroblasts by repeated chromatography. This enzyme is designated as hexosaminidase (hex) S. It reacts with antiserum prepared against homogeneous hex A but not with serum prepared against homogeneous hex B. These findings support our previously described model of the relationship between hex A and hex G: hex A has the structure (alpha beta)3, while hex B is (beta)6. Type B GM2 gangliosidosis (Tay-Sachs disease) is the alpha- mutation, while type 0 GM2 gangliosidosis (Sandhoff-Jatzkewitz disease) is the beta- mutation. In the absence of normal beta subunits there is increased polymerization of alpha subunits forming hex S, which probably has a structure of (alpha)6. A parallel between the thalassemias and GM2 gangliosidosis is evident: deficiency of one of the chains of which the protein is composed leads to an excess of polymers comprised of the other chains. In type B GM2 gangliosidosis, the excess of beta chanis leads to increased amounts of hex B beta)6; in type 0 GM2 gangliosidosis, the excess of alpha chains leads to formation of increased amounts of the alpha chain polymer, hex S.
Role of the UBL-UBA Protein KPC2 in Degradation of p27 at G<sub>1</sub> Phase of the Cell Cycle (2005)

KPC2 (Kip1 ubiquitylation-promoting complex 2) together with KPC1 forms the ubiquitin ligase KPC, which regulates degradation of the cyclin-dependent kinase inhibitor p27 at the G(1) phase of the cell cycle. KPC2 contains a ubiquitin-like (UBL) domain, two ubiquitin-associated (UBA) domains, and a heat shock chaperonin-binding (STI1) domain. We now show that KPC2 interacts with KPC1 through its UBL domain, with the 26S proteasome through its UBL and NH(2)-terminal UBA domains, and with polyubiquitylated proteins through its UBA domains. The association of KPC2 with KPC1 was found to stabilize KPC1 in a manner dependent on the STI1 domain of KPC2. KPC2 mutants that lacked either the NH(2)-terminal or the COOH-terminal UBA domain supported the polyubiquitylation of p27 in vitro, whereas a KPC2 derivative lacking the STI1 domain was greatly impaired in this regard. Depletion of KPC2 by RNA interference resulted in inhibition of p27 degradation at the G(1) phase, and introduction of KPC2 derivatives into the KPC2-depleted cells revealed that the NH(2)-terminal UBA domain of KPC2 is essential for p27 degradation. These observations suggest that KPC2 cooperatively regulates p27 degradation with KPC1 and that the STI1 domain as well as the UBL and UBA domains of KPC2 are indispensable for its function.
SKIN GRAFT FIXATION BY PLASMA-THROMBIN ADHESION* (1944)

Rochester, N. Y. FROM THE DEPARTMENT OF SURGERY, THE UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY AND THE STRONG MEMORIAL HOSPITAL, ROCHESTER, N. Y.
Routers with a single stage of buffering (2002)

Most high performance routers today use combined input and output queueing (CIOQ). The CIOQ router is also frequently used as an abstract model for routers: at one extreme is input queueing, at the other extreme is output queueing, and in-between there is a continuum of performance as the speedup is increased from 1 to N (where N is the number of linecards). The model includes architectures in which a switch fabric is sandwiched between two stages of buffering. There is a rich and growing theory for CIOQ routers, including algorithms, throughput results and conditions under which delays can be guaranteed. But there is a broad class of architectures that are not captured by the CIOQ model, including routers with centralized shared memory, and load-balanced routers. In this paper we propose an abstract model called Single-Buffered (SB) routers that includes these architectures. We describe a method called Constraint Sets to analyze a number of SB router architectures. The model helped identify previously unstudied architectures, in particular the Distributed Shared Memory router. Although commercially deployed, its performance is not widely known. We find conditions under which it can emulate an ideal shared memory router, and believe it to be a promising architecture. Questions remain about its complexity, but we find that the memory bandwidth, and potentially the power consumption of the router is lower than for a CIOQ router.
Importance of subtype in the immune response to the pre-S(2) region of the hepatitis B surface antigen. I. T cell fine specificity. (1990)

Previous studies of murine T cell recognition of the pre-S(2) region of the hepatitis B surface Ag (HBsAg) identified high (H-2b,d,q), intermediate (H-2s,k), and low to nonresponder (H-2f) haplotypes. However, these studies utilized the y subtype of HBsAg. The purpose of this study was to examine the influence of viral subtype on T cell recognition of the pre-S(2) region and to identify specific T cell recognition sites in a panel of H-2 congenic strains. Immunization with pre-S(2) containing HBsAg particles of the d and y subtypes indicated that T cell recognition of the pre-S(2) region is predominantly subtype-specific in murine strains of eight different H-2 haplotypes. Furthermore, the B10.M strain (H-2f) classified as a T cell nonresponder to the y subtype of the pre-S(2) region responds efficiently to the d subtype, indicating that pre-S(2) responder status can be subtype-dependent as well as subtype-specific. Studies using a truncated pre-S(2) polypeptide and synthetic peptides illustrated that the C-terminal sequence (p148-174) of the pre-S(2) region is the dominant focus of T cell recognition in multiple murine strains. Specifically, 17 distinct T cell recognition sites were defined within the C-terminal half of the pre-S(2) region. The fine specificity of T cell recognition of the pre-S(2) region was dependent on the H-2 haplotype of the responding strain. T cell recognition of all 17 sites was subtype specific, which is consistent with the fact that the C-terminal sequence is highly polymorphic between the d and y subtypes of the pre-S(2) region. Lastly, it was shown that the ability of synthetic peptides to elicit T cells cross-reactive with the native pre-S(2) region was variable and depended on the nature of the immunizing peptide. The pre-S(2)-containing HBsAg vaccines currently in clinical trials are composed of ra single subtype, either d or y. The results of this study suggest that both subtypes should be incorporated to increase the frequency of T cell responders to the pre-S(2) region, and to insure Th cell memory relevant to infection with hepatitis B virus of either the d or y subtypes.
Characterization of Residual Stress in Microelectromechanical Systems (MEMS) Devices Using Raman Spectroscopy (2002)

Due to the small scale of MEMS devices, the inherent residual stresses during the deposition processes can affect the functionality and reliability of the fabricated devices. Residual stress often causes device failure due to curling, buckling, or fracture. Currently, few techniques are available to measure the residual stress in MEMS devices. In this dissertation, Raman spectroscopy is used to measure and monitor the residual and induced stresses in MUMPs polysilicon MEMS devices. Raman spectroscopy was selected since it is nondestructive, fast, and provides potential in situ stress monitoring. Raman spectroscopy scans on unreleased and released MEMS fixed-fixed beams, cantilevers, and micromirror flexures were performed to obtain residual stress profiles. The profiles are compared to analytical models to assess the accuracy of Raman spectroscopy. I performed post-processing thermal anneals, phosphorous diffusions and phosphorous ion implantations to characterize the residual stress changes within MEMS devices. From post-processing experiments, the Raman residual stress profiles on MUMPs structures indicate a stress reduction by over 90%, which is verified with on-chip test structures. The reduced residual stress levels can improve the performance, reliability, and yield of the MEMS devices as they become smaller. In addition, I present the first Raman stress measurements in III-V MEMS.
Enhanced Open Circuit Voltage and Efficiency of Donor–Acceptor Copolymer Solar Cells by Using Indene-C60 Bisadduct (2012)

The photovoltaic properties of bulk heterojunction solar cells using indene-C60 bisadduct (ICBA) as the electron acceptor were investigated by using three donor–acceptor copolymers (PSEHTT, PSOTT, and PSOxTT) in comparison with PC61BM-based solar cells. The open circuit voltage of the copolymer:ICBA devices was 0.82–0.92 V, which is 0.25 V enhanced compared to the copolymer:PCBM solar cells. Compared to PCBM-based solar cells, the photocurrent density of ICBA-based devices was significantly increased in the case of PSEHTT but decreased in PSOTT and PSOxTT. This variation of photocurrent density with the copolymer structure was correlated with the charge photogeneration efficiency as determined by transient absorption spectroscopy. A power conversion efficiency of 5.4% was achieved in PSEHTT:ICBA solar cells, which represents a 50% enhancement in efficiency compared to PC61BM devices. Our results demonstrate that ICBA can significantly increase the open circuit voltage, current density, and power conversion efficiency of donor–acceptor copolymer-based BHJ solar cells.
Regulation of the human histamine H<sub>1</sub> receptor stably expressed in Chinese hamster ovary cells (1996)

1. The human H1 receptor gene expressed in Chinese hamster ovary cells (CHOhumH1) encodes a classical histamine H1 receptor with a pharmacology similar to that of the H1 receptor found in guinea-pig cerebellum and the endogenously expressed human H1 receptor in 1321N1 astrocytoma cells as determined by [3H]-mepyramine binding studies. 2. In CHOhumH1 cells, histamine induced a concentration-dependent rise in inositol phosphates (EC50 2.23 +/- 0.97 microM) and a rapid increase of [Ca2+]i, followed by a sustained increase of [Ca2+]i upon addition of 100 microM histamine. 3. Short-term exposure of CHOhumH1 cells to histamine (100 microM) resulted in a decrease of subsequent histamine-induced Ca2+ responses. The histamine-induced desensitization appeared to be heterologous as the ATP-induced Ca2+ response was also found to be affected. 4. The process of heterologous histamine-induced desensitization of the Ca2+ response in CHOhumH1 cells can be ascribed to an alteration at the level of the intracellular Ca2+ pool, as the Ca2+ response of caffeine (10 mM), which releases Ca2+ from intracellular Ca2+ stores was also attenuated upon short-term histamine exposure. 5. In CHOhumH1 cells the PKC activator, PMA, was found to inhibit the histamine (100 microM)-induced Ca2+ response concentration-dependently (IC50 0.2 +/- 0.03 microM) as well as the ATP (100 microM)-induced Ca2+ response. However, this inhibition was only partial and less effective than histamine-pretreatment. Moreover, in CHOhumH1 cells PKC downregulation induced by long-term exposure to PMA (1 microM) did not affect the histamine-induced desensitization nor did pretreatment with the specific PKC inhibitor Ro-31-8220 (10 microM), indicating that in CHOhumH1 cells PKC is probably not involved in the heterologous desensitization. 6. Long-term treatment of CHOhumH1 cells with histamine or other H1 agonists resulted in a time- and concentration-dependent decrease in the number of H1 receptor binding sites (maximal reduction: 47 +/- 5%). 7. Long-term exposure of CHOhumH1 cells to ATP or PMA did not affect H1 receptor density. 8. Both histamine (100 microM)- and ATP (100 microM)-induced Ca2+ responses were affected upon long-term exposure of cells to histamine (100 microM), which might be explained by an alteration at a level distant from the receptor. 9. These results show that in CHOhumH1 cells the human histamine H1 receptor is susceptible to short-term and long-term receptor regulation in which PKC does not seem to play a role. The CHOhumH1 cells therefore provide an excellent model system for studying the mechanism(s) of PKC-independent H1 receptor regulation.
Biosynthesis of Mycophenolic Acid (1973)

Comparative incorporation experiments with (1′- 14 C)-orsellinic acid (2) and (1′- 14 C)-4,6-dihydroxy-2,3-dimethylbenzoic acid (3) suggest that only the latter compound is a specific precursor of mycophenolic acid; the implication of this result in terms of the early stages of the biosynthetic sequence is noted.
Inactivation of VCP/ter94 Suppresses Retinal Pathology Caused by Misfolded Rhodopsin in Drosophila (2010)

The most common Rhodopsin (Rh) mutation associated with autosomal dominant retinitis pigmentosa (ADRP) in North America is the substitution of proline 23 by histidine (Rh(P23H)). Unlike the wild-type Rh, mutant Rh(P23H) exhibits folding defects and forms intracellular aggregates. The mechanisms responsible for the recognition and clearance of misfolded Rh(P23H) and their relevance to photoreceptor neuron (PN) degeneration are poorly understood. Folding-deficient membrane proteins are subjected to Endoplasmic Reticulum (ER) quality control, and we have recently shown that Rh(P23H) is a substrate of the ER-associated degradation (ERAD) effector VCP/ter94, a chaperone that extracts misfolded proteins from the ER (a process called retrotranslocation) and facilitates their proteasomal degradation. Here, we used Drosophila, in which Rh1(P37H) (the equivalent of mammalian Rh(P23H)) is expressed in PNs, and found that the endogenous Rh1 is required for Rh1(P37H) toxicity. Genetic inactivation of VCP increased the levels of misfolded Rh1(P37H) and further activated the Ire1/Xbp1 ER stress pathway in the Rh1(P37H) retina. Despite this, Rh1(P37H) flies with decreased VCP function displayed a potent suppression of retinal degeneration and blindness, indicating that VCP activity promotes neurodegeneration in the Rh1(P37H) retina. Pharmacological treatment of Rh1(P37H) flies with the VCP/ERAD inhibitor Eeyarestatin I or with the proteasome inhibitor MG132 also led to a strong suppression of retinal degeneration. Collectively, our findings raise the possibility that excessive retrotranslocation and/or degradation of visual pigment is a primary cause of PN degeneration.
Transcranial Magnetic Stimulation: A Novel Antidepressive Strategy? (1996)

Transcranial magnetic stimulation (TMS) is a well-established diagnostic probe in neurological practice. The increasing knowledge of biological mechanisms in electroconvulsive therapy presents a clear case for studying the applicability of TMS as a therapeutic tool in psychiatry. Based on the results of our pilot study showing a possible antidepressive effect of TMS, we conducted a controlled clinical trial on patients affected by major depression (DSM-III-R). Group 1 (n = 12) underwent TMS as add-on therapy to standard antidepressive medication, while group 2 (n = 12) was treated only with antidepressive medication. Already after the third add-on TMS session, a statistically significantly greater remission of depressive symptoms occurred in the patients of group 1 (p = 0.003). This statistically significant difference between the groups became even more marked on the last day of the study (p = 0.001, Wilcoxon). The results and further implications of TMS in psychiatric disorders are discussed.
Waltzing in the Garden (1993)

Pearly don't know how she going to get through the evening. She want to tell him. But she caan tell him. He only going think she forward or worse yet fool fool. For don't that's what her sister did say, 'Pearly you fool fool eh chile!' But if she don't tell him, how she going know ... ? Pearly mixing up the ice cream worse than when she first start the job ... people want guava, she scooping up paw paw or mango, tamarind, ginger, why they don't just want chocolate, it easy to find ... as for vanilla, rum and nut, sweetsop and coconut all of them the same colour ... coconut that is how it all start...
Traffic Control and Traffic Management in a Transportation System with Autonomous Vehicles (2016)

This paper aims to quantify the effects of autonomous driving on the traffic management level. This involves developing a model of autonomous driving that makes it possible to use human-controlled and autonomous vehicles with only minor modifications.
The complexity of complexes in signal transduction (2003)

Many activities of cells are controlled by cell-surface receptors, which in response to ligands, trigger intracellular signaling reactions that elicit cellular responses. A hallmark of these signaling reactions is the reversible nucleation of multicomponent complexes, which typically begin to assemble when ligand-receptor binding allows an enzyme, often a kinase, to create docking sites for signaling molecules through chemical modifications, such as tyrosine phosphorylation. One function of such docking sites is the co-localization of enzymes with their substrates, which can enhance both enzyme activity and specificity. The directed assembly of complexes can also influence the sensitivity of cellular responses to ligand-receptor binding kinetics and determine whether a cellular response is up- or downregulated in response to a ligand stimulus. The full functional implications of ligand-stimulated complex formation are difficult to discern intuitively. Complex formation is governed by conditional interactions among multivalent signaling molecules and influenced by quantitative properties of both the components in a system and the system itself. Even a simple list of the complexes that can potentially form in response to a ligand stimulus is problematic because of the number of ways signaling molecules can be modified and combined. Here, we review the role of multicomponent complexes in signal transduction and advocate the use of mathematical models that incorporate detail at the level of molecular domains to study this important aspect of cellular signaling.
HuggingFace's Transformers: State-of-the-art Natural Language Processing (2019)

Recent progress in natural language processing has been driven by advances in both model architecture and model pretraining. Transformer architectures have facilitated building higher-capacity models and pretraining has made it possible to effectively utilize this capacity for a wide variety of tasks. \textit{Transformers} is an open-source library with the goal of opening up these advances to the wider machine learning community. The library consists of carefully engineered state-of-the art Transformer architectures under a unified API. Backing this library is a curated collection of pretrained models made by and available for the community. \textit{Transformers} is designed to be extensible by researchers, simple for practitioners, and fast and robust in industrial deployments. The library is available at \url{https://github.com/huggingface/transformers}.
Creating web service interfaces and scientific workflows using command line tools: A GRASS example (2009)

With tremendous increase in data from earth and space based sensors, there is growing realization within geoscience community that technologies like Web services and allied technologies need to be leveraged for geospatial data analysis and management. Traditionally, standalone geographic information systems software was used for these tasks. Adaptation of this software for use in Web services raises several issues and challenges. We have created large number of Web services on top of geographic resources analysis support system (GRASS GIS), which is an open source command line GIS software. In this paper the conceptual architecture used in developing the Web services is presented in detail. This architecture has different layers of services. The user of services at each layer is immune from having to know the details of lower level services and software. The geospatial model developer, who develops services at highest layer, can work at conceptual level without having to learn specifics of any particular software. The model developer can concentrate on the model itself rather than on many unnecessary and time consuming details. Some of the issues that we encountered during the development - granularity of services, statelessness of services and interoperability between services - are also discussed.
Comparison of Neurological Scales and Scoring Systems for Acute Stroke Prognosis (1996)

Baseline NIHSS best predicts 3-month outcome. The Canadian Neurological Scale and Middle Cerebral Artery Neurological Score also perform well. Baseline assessments in clinical trials only need to include a single stroke rating scale.
Fetal nuchal translucency screening in 12 495 pregnancies in Sardinia (2001)

Screening for chromosomal defects by measurement of nuchal translucency thickness identifies 80% of fetuses with trisomy 21 for a false-positive rate of 5%. In our population with a median maternal age of 33 years, screening by a combination of maternal age and fetal nuchal translucency thickness with a risk cut-off of 1 in 300 identified 90% of trisomy 21 pregnancies for a false-positive rate of 9%.
Identification of a Tsetse Fly Salivary Protein with Dual Inhibitory Action on Human Platelet Aggregation (2010)

These data show that this 5'nucleotidase-related apyrase exhibits GPIIb/IIIa antagonistic properties and represents a key thromboregulatory compound of tsetse fly saliva.
Ultra-thin porous silica coated silver–platinum alloy nano-particle as a new catalyst precursor (2003)

Templated sol–gel encapsulation of surfactant-stabilised micelles containing metal precursor(s) with ultra-thin porous silica coating allows solvent extraction of organic based stabiliser from the composites in colloidal state hence a new method of preparing supported alloy catalysts using the inorganic silica-stabilised nano-sized, homogenously mixed, silver–platinum (Ag–Pt) colloidal particles is reported.
Light field data processor design for depth estimation using confidence-assisted disparities (2013)

In this paper, we propose a hardware-compatible light field data processing algorithm for depth estimation. This method combines Average Absolute Difference (AAD) technique and a confidence weighted check to calculate disparities between sub-images, from which depths of objects in the scenes can be obtained. We implement the algorithm using both software and hardware approaches. In the hardware design, we reuse the circuit block for 0/90-degree AAD comparison in the first pass, and 45-degree AAD comparison in the second pass to balance hardware complexity and computing speed. The speed-up of more than 12 times can be achieved in the pipelined version.