gebhart/patrepeval huggingface dataset:
Co‐expression of osteopontin and CD44v9 in gastric cancer (1998)

We have examined the expression of osteopontin (OPN) in 40 human primary gastric carcinoma tissues, 5 metastatic foci (lymph nodes) and corresponding normal mucosas. Twenty-nine of 40 primary tumors (72.5%) and 3 of 5 lymph node metastases (60%) overexpressed OPN mRNA in comparison with those of the corresponding normal mucosa. The incidence as well as relative expression level of OPN mRNA was higher in well differentiated gastric cancers than poorly differentiated ones. Moreover, increased OPN mRNA expression in primary tumor specimens was observed along with the advancement of the clinico-pathological stage. Using in situ hybridization (ISH) analysis, not only inflammatory cells in tumor stroma but also tumor cells showed positive signals for OPN mRNA. By immunohistochemistry, co-immunoreaction of OPN and CD44v9 in tumor cells obviously correlated with the degree of lymphatic vessel invasion or long distant lymph node metastases in poorly differentiated gastric cancer. Interestingly, strong co-immunoreaction of OPN and CD44v9 of tumor cells was concommitant with cluster formation in the lymphatic vessels. Our results suggest that overexpression of OPN correlated with the progression of human gastric carcinoma. Especially in CD44-bearing poorly differentiated gastric cancer, interaction between OPN and CD44 may parallel lymphogenous metastasis. Int. J. Cancer (Pred. Oncol.) 79:127–132, 1998.© 1998 Wiley-Liss, Inc.
Transcriptional activity of ecdysone receptor isoforms is regulated by modulation of receptor stability and interaction with Ab‐ and C‐domains of the heterodimerization partner ultraspiracle (2009)

The stability of ecdysone receptor (EcR) expressed in a heterologous system is regulated in an isoform-specific manner and modified by ligand and heterodimerization partner. Transcriptional activities of various receptor complexes with Usp and ligand as determined by reporter assays are the result of two effects: change in receptor concentration and altered transcriptional capability. Transcriptional activity of EcR-A is low when compared to EcR-B1 independent of the absence or presence of Ultraspiracle (Usp). Ligand increased the concentration of EcR-A, but had no effect on the transcriptional capability, in contrast to EcR-B1, which is not stabilized by hormone or Usp, but the transcriptional capability is enhanced by heterodimerization and ligand. Exchange of the AB-domain of Usp by the activation domain (AD) of Vp16 revealed that the N-terminus of Usp inhibited transcriptional activity only with EcR-B isoforms, whereas the hexapeptide in the AB-domain of wild type Usp adjacent to the C-domain of Usp harbours an activating function. Deletion of the C-domain of Usp did not affect the stability of the receptor complex, but reduced the transcriptional capability of heterodimers with all EcR-isoforms, indicating that the stability of the receptor, which is important for termination of the hormone signal transduction, is regulated in a cooperative manner by the AB-domains of EcR and Usp, and ligand. We show the active role of Usp in modulation of the transcriptional activity of the heterodimer in an isoform-specific manner by the inhibitory N-terminus, the activating hexapeptide in the AB-domain, and the C-domain of Usp.
Synthesis, Properties, and Oxidizing Ability of Areno-Annulated 1,3-Dimethyl-10-phenylcyclohepta[4,5]pyrrolo[2,3-<i>d</i>]pyrimidine- 2,4(1,3<i>H</i>)-dionylium Ions (2005)

[structures: see text] Novel areno-annulated 1,3-dimethyl-10-phenylcyclohepta[4,5]pyrrolo[2,3-d]pyrimidine-2,4(1,3H)-dionylium ions 12a,b+ x BF4(-) and 16a+ x BF4(-) were synthesized by three-step reactions, starting from the reactions of benzo[b]tropone and naphtho[2,3-d]tropone with 6-anilino-1,3-dimethyluracil. Structural characteristics of 12a,b+ and 16a+ were clarified on inspection of the UV-vis and NMR spectral data as well as by X-ray crystal analyses. The stability of cations 12a,b+ and 16a+ is expressed by the pK(R+) values which were determined spectrophotometrically as the values of ca. 0.5-9.0. The pK(R+) value of the naphtho[b]tropylium ion 4+ was clarified to be much lower, at <0. The electrochemical reduction of 12a,b+ and 16a+ exhibited reduction potentials at -0.46 to -0.67 (V vs Ag/AgNO3) upon cyclic voltammetry (CV). The reduction potentials of the benzotropylium ion and cation 4+ were -0.26 and -0.09 V, respectively. In a search for reactivity, reactions of 12a,b+ x BF4(-) with some nucleophiles, hydride and diethylamine, were carried out. Although the reactions of 12a+ x BF4(-) afforded C11 adduct 19 as a single product, the addition reactions of 12b+ x BF4(-) proceeded at both C9 and C11. The attempted reduction of methyl benzoylformate by using 21 was carried out unsuccessfully. The photoinduced oxidation reaction of 12a,b+ x BF4(-) and 16a+ x BF4(-) toward some amines under aerobic conditions was carried out to give the corresponding imines (isolated by converting to the corresponding 2,4-dinitrophenylhydrazones) with the recycling number of 3.6-21.7.
Retinoid Induces the Degradation of Corneodesmosomes and Downregulation of Corneodesmosomal Cadherins: Implications on the Mechanism of Retinoid-induced Desquamation (2011)

Our results indicate that DSG1 and DSC1 downregulation by RA could be related to the increased degradation of corneodesmosomes and consequent desquamation induced by retinoids.
In vivo MR spectroscopic imaging with P-31. Work in progress. (1984)

Magnetic resonance imaging techniques were applied to in vivo spectroscopic analysis of spatially resolved phosphorus spectra in the cat brain to determine whether changes associated with stroke could be detected. Two-dimensional images of separate phosphorus-containing compounds, as well as spectra arising from spatially localized points, demonstrated that metabolism within tissue could be monitored in this manner. Preliminary results of phosphorus imaging of the human body in vivo are reported.
Incremental Maintenance for Leapfrog Triejoin (2013)

We present an incremental maintenance algorithm for leapfrog triejoin. The algorithm maintains rules in time proportional (modulo log factors) to the edit distance between leapfrog triejoin traces.
<title>Overview of image security techniques with applications in multimedia systems</title> (1998)

The growth of networked multimedia system has created a need for the copyright protection of digital images and video. Copyright protection involves the authentication of image content and/or ownership. This can be used to identify illegal copies of an image. One approach is to mark an image by adding an invisible structure known as a digital watermark to the image. Techniques of incorporating such a watermark into digital images include spatial-domain techniques, transform-domain algorithms and sub-band filtering approaches.
Non-fibrous fillers for epoxy resin formulations (1967)

Non-reinforcing fillers are commonly used in epoxy resin formulations to reduce shrinkage, improve thermal shock resistance, dissipate heat, impart flame retardancy and lower costs. Because of the numerous types of fillers available and the lack of systematic comparisons of the effect of these fillers on properties of representative epoxy formulations, selection of the optimum filler for a given application may involve considerable guess-work. The principal objective of this study is to provide comparative data illustrating the effect of 19 fillers on the electrical properties, shrinkage, thermal shock resistance, water resistance, viscosity and stability of two typical epoxy resin formulations. A flexibilized anhydride cured epoxy system of the type used for electrical encapsulations and a general purpose, rigid, aliphatic amine cured epoxy system were selected as the binders for this study. Filler loadings were equated on a volume concentration basis because of the wide difference in densities of the fillers studied and the more direct relationship of properties such as shrinkage, thermal shock resistance, viscosity and cost per manufactured unit to volume concentration rather than weight concentration.
Alcohol fermentation of corn starch digested by <i>Chalara paradoxa</i> amylase without cooking (1987)

Alcohol fermentation of corn starch without cooking was performed by using Chalara paradoxa glucoamylase preparation, which had stronger raw starch digesting activity than those of the conventionally known glucoamylases. A raw corn starch-enzyme-yeast mixture was fermented optimally at pH 5.0 and 30 degrees C for five days and produced ethanol. The yields of ethanol were between 63.5 and 86.8% of the theoretical value by baker's yeast (Saccharomyces cerevisiae), and between 81.1 and 92.1% of the theoretical value by sake yeast (Saccharomyces sake).
Fabrication of C-SiC composite mirrors (2003)

A novel technology to fabricate ultralightweight mirrors was demonstrated. High thermal conductivity C-C composite integrated honeycomb face sheets were fabricated using a tape layup. Chemical vapor deposition (CVR)-SiC was employed to produce a functionally graded transition in CTE from about 0 ppm/K to about 4.5 ppm/K A crack free CVR-SiC surface was achieved which was subsequently polished. A 1 kg/m/sup 2/ SiC mirror structure was demonstrated for a 12 cm structure and 1 kg/m/sup 2/ was demonstrated for a 0.5 in structure.
Supporting distributed experts in e-meetings for synchronous collaboration (2003)

This paper presents an analysis of the main requirements to support synchronous collaborative activities. Then, a collaborative platform, PLATINE, composed of a complete set of tools for synchronous group work support and collaboration session management, is presented. Focus is made on two important components: videoconference and session manager. Afterwards, a set of experiments is described. A co-design scenario in the electronic domain is detailed.
Energy efficient continuous production of γ-valerolactone by bifunctional metal/acid catalysis in one pot (2014)

A bifunctional heterogeneous catalyst based on sulfonated cation exchange resin and embedded Ru nanoparticles shows complete conversion and selectivity at low temperatures and H2 pressure in the direct, one-pot conversion of levulinic acid to GVL under continuous flow conditions, with excellent durability and no need for additives.
Resolving the Base of the Relativistic Jet in M87 at 6Rsch Resolution with Global mm-VLBI (2016)

M87 is one of the nearest radio galaxies with a central Super-Massive Black Hole (SMBH) and a prominent relativistic jet. Due to its close distance to the observer and the large SMBH mass, the source is one of the best laboratories to obtain strong observational constraints on the theoretical models for the formation and evolution of the AGN jets. In this article, we present preliminary results from our ongoing observational study about the innermost jet of M87 at an ultra-high resolution of ∼50 μ as achieved by the Global Millimeter-Very Long Baseline Interferometry Array (GMVA). The data obtained between 2004 and 2015 clearly show limb-brightened jets at extreme resolution and sensitivity. Our preliminary analysis reveals that the innermost jet expands in an edge-brightened cone structure (parabolic shape) but with the jet expansion profile slightly different from the outer regions of the jet. Brightness temperatures of the Very Long Baseline Interferometry (VLBI) core obtained from cm- to mm-wavelengths show a systematic evolution, which can be interpreted as the evolution as a function of distance from the BH. We also adopt an alternative imaging algorithm, Bi-Spectrum Maximum Entropy Method (BSMEM), to test reliable imaging at higher angular resolution than provided by the standard CLEAN method (i.e., super-resolution). A demonstration with a VLBA 7 mm example data set shows consistent results with a near-in-time 3 mm VLBI image. Application of the method to the 2009 GMVA data yields an image with remarkable fine-scale structures that have been never imaged before. We present a brief interpretation of the complexity in the structure.
AMOEBACIDAL EFFECTS OF SERUM FROM THE AMERICAN ALLIGATOR (ALLIGATOR MISSISSIPPIENSIS) (2004)

Treatment of axenic Naegleria gruberi cultures with alligator serum resulted in time-dependent amoebacidal activity, with measurable activity at 5 min and maximal activity occurring at 20 min. The amoebacidal activity was concentration dependent, with measurable activity at 25% serum, whereas treatment of amoebas with undiluted serum resulted in only 16% survival. The efficacy was dependent on the concentration of amoebas, with higher survival rates at high amoeba densities and lower survival rates at low amoeba densities. The amoeba-killing effects of alligator serum were broad in spectrum because the serum was effective against 3 strains of Naegleria species tested and 4 Acanthamoeba species, which have been reported to be resistant to human serum complement-mediated lysis. The amoebacidal effects of alligator serum were temperature dependent, with optimal activity at 15-30 C and a decrease in activity below 15 C and above 30 C. The amoebacidal activity of alligator serum was heat labile and protease sensitive, indicating the proteinaceous nature of the activity, and was also inhibited by ethylenediaminetetraacetic acid, which indicated a requirement for divalent metal ions. These characteristics strongly suggest that the amoebacidal properties of alligator serum are because of complement activity.
Pre-virtualization: Soft layering for virtual machines (2008)

Despite its current popularity, para-virtualization has an enormous cost. Its deviation from the platform architecture abandons many of the benefits of traditional virtualization: stable and well-defined platform interfaces, hypervisor neutrality, operating system neutrality, and upgrade neutrality - in sum, modularity. Additionally, para-virtualization has a significant engineering cost. These limitations are accepted as inevitable for significantly better performance, and for the ability to provide virtualization-like behavior on non-virtualizable hardware such as times86. Virtualization and its modularity solve many systems problems, and when combined with the performance of para-virtualization become even more compelling. We show how to achieve both together. We still modify the guest operating system, but according to a set of design principles that avoids lock-in, which we call soft layering. Additionally, our approach is highly automated and thus reduces the implementation and maintenance burden of paravirtualization, which is especially useful for enabling obsoleted operating systems. We demonstrate soft layering on times86 and itanium: we can load a single Linux binary on a variety of hypervisors (and thus substitute virtual machine environments and their enhancements), while achieving essentially the same performance as para-virtualization with less effort.
Multi axle order tracking with the Vold-Kalman tracking filter (1997)

The Vold-Kalman filter allows for the high performance simultaneous tracking of orders in systems with multiple independent axles. The interactions associated with close and crossing orders give rise to beating and complex psychoacoustic phenomena. With this new filter and using multiple tachometer references, waveforms as well as amplitude and phase may be extracted without the beating interactions that are associated with conventional methods. The Vold-Kalman filter provides several filter shapes for optimum resolution and stopband suppression. Orders extracted as waveforms have no phase bias and may, therefore, be used in synthesis and tailoring. Vold and Leuridan 1 in 1993 introduced an algorithm for high resolution, slew rate independent order tracking based on the concepts of Kalman filters. 9,10 The algorithm has been highly successful as implemented in a commercial software system in solving data analysis problems previously intractable with other analysis methods. At the same time certain deficiencies have surfaced, prompting the development of an improved formulation. This article presents the new Vold-Kalman algorithm and some of its applications in the Bruel & Kjaer PULSE, MultiAnalyzer system. 5 Order tracking is the art and science of extracting the sinusoidal content of measurements from acousto-mechanical systems under periodic loading. Order tracking is used for troubleshooting, design and synthesis. Each periodic loading produces sinusoidal overtones, or orders, or harmonics, at frequencies that are multiples of that for the fundamental tone. The orders may be regarded as amplitude modulated carrier waves that frequency hop. Many practical systems have multiple axles that may run coherently through locked up transmissions, may be partially related through belt slippage and control loops, or may run independently, such as when a cooling fan cycles in an engine compartment. The Vold-Kalman algorithm allows for the simultaneous estimation of multiple orders, effectively decoupling close and crossing orders. This is especially important for acoustics applications, where order crossings cause transient beating events. The new algorithm allows for a much wider range of filter shapes, such that signals with sideband modulations are processed with high fidelity. Finally, systems subject to radical RPM changes, such as transmissions, are also tracked through the transient events associated with abrupt changes in inertia and boundary conditions. The order functions are extracted without phase error, and may then be used in synthesis applications for sound quality and laboratory simulations.
Gas Separation, Free Volume Distribution, and Physical Aging of a Highly Microporous Spirobisindane Polymer (2008)

PALS results show a bimodal pore size distribution for a spirobisindane polymer, with the majority of pores being of the larger size. Gas permeability, density and PALS results suggest the polymer undergoes physical aging during permeability testing. PALS results also show that solution processing generates extra free volume above the intrinsic free volume of the precipitated polymer.
A Single Cylinder Medium Speed Diesel Engine Research Facility (1988)

<div class="htmlview paragraph">A Single Cylinder Medium Speed diesel engine research facility has been developed for investigating areas of current technical concern to the rail, marine and stationary power industries. The design and operation of this Single Cylinder Research Engine (SCRE) is described. The facility is centered around a Bombardier model 251-plus 11.0 L engine which is representative of four stroke multi-cylinder railroad, marine and small stationary powerplant engines. All engine support systems (air, cooling water, fuel oil and lubricating oil pumps) operate independent of the engine enabling a wide range of adjustments in flow, pressure and temperature. Current program areas for which this system is used include alternative fuels evaluation, combustion analyses, fuel injection system development, component wear and durability studies, engine friction analyses, lubricant testing and emissions evaluations.</div>
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model (2010)

Synaptic dysfunction and the loss of synapses are early pathological features of Alzheimer's disease (AD). Synapses are sites of high energy demand and extensive calcium fluctuations; accordingly, synaptic transmission requires high levels of ATP and constant calcium fluctuation. Thus, synaptic mitochondria are vital for maintenance of synaptic function and transmission through normal mitochondrial energy metabolism, distribution and trafficking, and through synaptic calcium modulation. To date, there has been no extensive analysis of alterations in synaptic mitochondria associated with amyloid pathology in an amyloid β (Aβ)-rich milieu. Here, we identified differences in mitochondrial properties and function of synaptic vs. nonsynaptic mitochondrial populations in the transgenic mouse brain, which overexpresses the human mutant form of amyloid precursor protein and Aβ. Compared with nonsynaptic mitochondria, synaptic mitochondria showed a greater degree of age-dependent accumulation of Aβ and mitochondrial alterations. The synaptic mitochondrial pool of Aβ was detected at an age as young as 4 mo, well before the onset of nonsynaptic mitochondrial and extensive extracellular Aβ accumulation. Aβ-insulted synaptic mitochondria revealed early deficits in mitochondrial function, as shown by increased mitochondrial permeability transition, decline in both respiratory function and activity of cytochrome c oxidase, and increased mitochondrial oxidative stress. Furthermore, a low concentration of Aβ (200 nM) significantly interfered with mitochondrial distribution and trafficking in axons. These results demonstrate that synaptic mitochondria, especially Aβ-rich synaptic mitochondria, are more susceptible to Aβ-induced damage, highlighting the central importance of synaptic mitochondrial dysfunction relevant to the development of synaptic degeneration in AD.
A Randomized Trial of Induction Therapy (Daunorubicin, Vincristine, Prednisone versus Daunorubicin, Vincristine, Prednisone, Cytarabine and 6-Thioguanine) in Adult Acute Lymphoblastic Leukemia with Long-term Follow-up: An Eastern Cooperative Oncology Group Study (E3486) (2003)

In this study of previously untreated adult acute lymphocytic leukemia (ALL) performed by the Eastern Cooperative Oncology Group, patients were randomized to induction therapy with either DVP (daunorubicin 45 mg/m2 daily, days 1, 2 and 3; prednisone 60 mg/m2 daily orally days 1-35; and vincristine 2 mg intravenously on days 1, 8, 15 and 22) or DATVP (daunorubicin 60 mg/m2 daily, days 1, 2 and 3; cytarabine 25 mg/m2 intravenous bolus followed by 200 mg/m2 daily as a continuous infusion on days 1-5; 6-thioguanine 100 mg/m2 orally every 12 h on days 1-5; vincristine 2 mg intravenously on days 1 and 8; and prednisone 60 mg/m2/day orally, days 1-7. Complete responders to both regimens received the same post-remission therapy, which consisted of a single course of cytarabine 3 gm/m2 infused over 1 h every 12 h for 12 doses. One month later those patients still in remission received six cycles of consolidation therapy with MACHO (cyclophosphamide 650 mg/m2, doxorubicin 40 mg/m2 vincristine 2mg all intravenously on day 1 with prednisone 100 mg/m2 orally daily on days 1-5. Methotrexate 200 mg/m2 intravenously and L-asparaginase 6000 U/m2 were given on day 22 and each course was given every 5 weeks. A single dose of intrathecal methotrexate was also given with each MACHO course. There were 276 evaluable patients randomized in this study. Complete response rates were 71% for DVP and 58% for DATVP. Median durations of complete response were 5.5 and 6.8 months, respectively. Median survival of all randomized patients was 14.4 months in each group. DATVP was more toxic than DVP. Intensification of treatment for adults with ALL may not improve outcome. Progress in the treatment of adults with ALL will require the identification of new agents for this neoplasm.
Pattern of DAP12 Expression in Leukocytes from Both Healthy and Systemic Lupus Erythematosus Patients (2009)

DAP12 is an ITAM-bearing transmembrane adaptor originally identified on the surface of Natural Killer cells. A broad expression among other immune cells was later found in myeloid and lymphoid cells. However, data on DAP12 expression pattern rely only on immunoblot and microarray analysis. Here, we describe the generation and the characterization of an anti-DAP12 monoclonal antibody. Using this novel reagent, we show that DAP12 expression is restricted to innate immune cells in basal condition. Since a decreased expression of DAP12 has been suggested in NK cells of systemic lupus erythematosus patients, we have further investigated the NK cell receptor repertoire and leukocyte expression of DAP12 in these patients and no major changes were detectable when compared to controls.