gebhart/patrepeval huggingface dataset:
Identification of a lysyl residue in antithrombin which is essential for heparin binding. (1987)

Identification of lysyl residue(s) in human plasma antithrombin required for binding of heparin was approached using chemical modification with the amino-group reagent pyridoxal 5'-phosphate. Modification of antithrombin with limiting amounts of reagent yields an average incorporation of the phosphopyridoxyl label into 1 lysine/protein molecule (Pecon, J. M., and Blackburn, M. N. (1984) J. Biol. Chem. 259, 935-938). Fractionation of the labeled antithrombin by affinity chromatography on heparin-Sepharose separated a phosphopyridoxylated antithrombin species devoid of heparin binding from modified protein which retained affinity for heparin. To generate peptide maps of the two antithrombin species, the proteins were reductively denatured, S-carboxymethylated, and digested with trypsin. Fractionation of the tryptic digests by reverse-phase high performance liquid chromatography indicated one peak in the chromatogram of the non-heparin-binding species to be clearly different when compared to the chromatogram of the heparin-binding species. The sequence of the unique peptide, determined by automated Edman degradation, was Thr-Ser-Asp-Gln-Ile-His-Phe-Phe-Phe-Ala-Lys-Leu-Asn-Cys-Arg. This peptide corresponds to a tryptic fragment including residues 115-129 in the sequence of antithrombin, with the modified residue identified as Lys-125. Additionally, phosphopyridoxylation of antithrombin in the presence of added heparin indicated that several other lysyl residues were "protected" from modification. Identification of this critical lysine for heparin binding strongly supports previous data which indicate that the heparin-binding domain of antithrombin is located at the NH2 terminus within one of the disulfide cross-linked loops of the protein.
A Medium-Voltage Large Wind Turbine Generation System Using an AC/AC Modular Multilevel Cascade Converter (2015)

The generator voltage of a cutting-edge wind turbine generation system (WTGS) is expected to increase from the conventional low-voltage level of 690 V to a medium-voltage level of 6.6 kV with a power level up to 10 MW without the application of a parallel connection of multiple power units. On the other hand, it is difficult to use a conventional two-level or three-level converter in a WTGS with a dc-link voltage of 10-13 kV owing to the limitations on the voltage ratings of power devices. This paper presents a 10-MW WTGS consisting of a three-phase open-winding synchronous generator equipped with six lead terminals and a modular multilevel cascade converter (MMCC) formed by three identical subconverters. The MMCC carries out direct ac/ac power conversion from three single-phase voltages with a time-varying frequency (from the generator) to a three-phase voltage with a line frequency of 50 Hz. This paper discusses the operating principles and control methods for the WTGS, followed by simulations using the software package PSCAD/EMTDC. The experimental result obtained from a 200 V 6-kW downscaled system confirms the reliability of simulation results of the complete three-phase system.
Room-temperature pulsed operation of strained GaInNAs/GaAsdoublequantum well laser diode grown by metal organic chemical vapourdeposition (1998)

A strained GaInNAs/GaAs double quantum-well laser is developed by metal organic chemical vapour deposition. Almost 1.2 µm at room-temperature under pulsed operation is demonstrated. The threshold current density is lower than that of a laser with a GaInNAs bulk active layer.
Eye movements and optical flow (1990)

Translation of an observer through a static environment generates a pattern of optical flow that specifies the direction of self-motion, but the retinal flow pattern is confounded by pursuit eye movements. How does the visual system decompose the translational and rotational components of flow to determine heading? It is shown that observers can perceive their direction of self-motion during stationary fixations and pursuit eye movements and with displays that simulate the optical effects of eye movements. Results indicate that the visual system can perform the decomposition with both continuous and discontinuous fields on the basis of flow-field information alone but requires a three-dimensional environmental structure to do so. The findings are inconsistent with general computational models and theories based on the maximum of divergence, oculomotor signals, or multiple fixations but are consistent with the theory of reliance on differential motion produced by environmental variation in depth.
Inkjet Printing of Silver Nanowire Networks (2015)

The development of printed electronics will require the ability to deposit a wide range of nanomaterials using printing techniques. Here we demonstrate the controlled deposition of networks of silver nanowires in well-defined patterns by inkjet printing from an optimized isopropyl alcohol-diethylene glycol dispersion. We find that great care must be taken while producing the ink and during solvent evaporation. The resultant networks have good electrical properties, displaying sheet resistances as low as 8 Ω/□ and conductivities as high as 10(5) S/m. Such optimized performances were achieved for line widths of 1-10 mm and network thicknesses of 0.5-2 μm deposited from ∼10-20 passes while using processing temperatures of no more than 110 °C. Thin networks are semitransparent with dc to optical conductivity ratios of ∼40.
Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells (2007)

Many chemoradiation therapies cause DNA damage through oxidative stress. An important cellular mechanism that protects cells against oxidative stress involves DNA repair. One of the primary DNA repair mechanisms for oxidative DNA damage is base excision repair (BER). BER involves the tightly coordinated function of four enzymes (glycosylase, apurinic/apyrimidinic endonuclease, polymerase and ligase), in which 8-oxoguanine DNA glycosylase 1 initiates the cycle. An imbalance in the production of any one of these enzymes may result in the generation of more DNA damage and increased cell killing. In this study, we targeted mitochondrial DNA to enhance cancer chemotherapy by over-expressing a human 8-oxoguanine DNA glycosylase 1 (hOGG1) gene in the mitochondria of human hepatoma cells. Increased hOGG1 transgene expression was achieved at RNA, protein and enzyme activity levels. In parallel, we observed enhanced mitochondrial DNA damage, increased mitochondrial respiration rate, increased membrane potential and elevated free radical production. A greater proportion of the hOGG1-over-expressing hepatoma cells experienced apoptosis. Following exposure to a commonly used chemotherapeutic agent, cisplatin, cancer cells over-expressing hOGG1 displayed much shortened long-term survival when compared with control cells. Our results suggest that over-expression of hOGG1 in mitochondria may promote mitochondrial DNA damage by creating an imbalance in the BER pathway and sensitize cancer cells to cisplatin. These findings support further evaluation of hOGG1 over-expression strategies for cancer therapy.
Role of human <i>MDR1</i> gene polymorphism in bioavailability and interaction of digoxin, a substrate of P‐glycoprotein (2002)

The allelic variants in the human MDR1 gene are likely to be associated with altered absorption and/or disposition profiles of digoxin and P-glycoprotein-mediated drug interaction
Providing Time-Related Constraints for Conventional Database Systems (1987)

A model for a historical database is described which is based upon time-stamped tuples as the unit of storage. The model includes both physical and logical time-stamps. The techni-cal characteristics of write-once laser discs prevent the use of double logical time-stamps. The model distinguishes version from correction-updates. It is shown that if set-valued attributes are involved the use of null values is unavoidable if back-dated correction-updates are allowed. A method of handling user-defined integrity constraint rules is outlined which involves the mainte-nance of a time-stamped trace of such rules.
Load anticipation feature and its tuning method for a diesel generating set (2016)

This paper presents a patent pending [1] load anticipation feature (LAF) which provides an effective improvement in load application performance for diesel generating sets. The large real-power load is measured and a proper feed-forward signal is provided to the governor in order to minimize engine speed deviation. LAF is implemented in the voltage regulator since it recognizes the load changes in advance of the engine. It can help the engine anticipate throttle adjustments in advance of the load being seen by the engine. A Swarm Intelligence (SI) technique is proposed to identify the LAF parameters. It is a robust tuning method that requires a minimum number of parameters to be identified for an equivalent speed control system. Test results show an improvement in the engine speed recovery effectively after a large increase in load.
Novel PU‐type polymeric photoinitiator comprising side‐chain benzophenone and coinitiator amine for photopolymerization of PU acrylate (2008)

Abstract A novel diamine 3,5‐diamino‐4′‐phenoxylbenzophenone (DAPBP) was synthesized from the reaction of 3,5‐diamino‐4′‐chlorobenzophenone (DACBP) and phenol. Then through the polycondensation of DAPBP, toluene‐2,4‐diisocyanate (TDI), and N ‐methyldiethanolamine (MDEA), we obtained a PU‐type polymeric photoinitiator containing side‐chain benzophenone (BP) and tertiary amine in the same macromolecule (PUSOA). Another polymeric photoinitiator without coinitiator amine in polymer chain (PUSO) was also synthesized for comparison. FT‐IR, 1 H NMR, and GPC analyses confirmed the structures of monomer and polymeric photoinitiators. The UV–Vis spectra of PUSOA, PUSO, and DAPBP are similar, and all exhibit the maximal absorption near 290 nm. ESR spectra indicate that PUSOA can generate active species most efficiently. The photopolymerization of PU acrylate, initiated by PUSOA, PUSO/MDEA, DAPBP/MDEA, and BP/MDEA, was studied by differential scanning photocalorimetry (photo‐DSC). The results show that the in‐chain coinitiator amine can significantly improve the photoefficiency of the polymeric photoinitiator and the PUSOA is more efficient for the polymerization of PU acrylate than its low‐molecular‐weight counterpart. Copyright © 2008 John Wiley & Sons, Ltd.
Static analysis of Java enterprise applications: frameworks and caches, the elephants in the room (2020)

Enterprise applications are a major success domain of Java, and Java is the default setting for much modern static analysis research. It would stand to reason that high-quality static analysis of Java enterprise applications would be commonplace, but this is far from true. Major analysis frameworks feature virtually no support for enterprise applications and offer analyses that are woefully incomplete and vastly imprecise, when at all scalable.
On-treatment predictions of success in peg-interferon/ribavirin treatment using a novel formula. (2010)

These results suggested that our formula combined with viral kinetics provides a clear direction of therapy for each patient and enables the best tailored treatment.
Primary structure of tyrosinase from Neurospora crassa. I. Purification and amino acid sequence of the cyanogen bromide fragments. (1982)

Cyanogen bromide (CB) cleavage of Neurospora tyrosinase resulted in four major fragments, CB1 (222 residues), CB2 (82 residues), CB3 (68 residues), and CB4 (35 residues), and one minor overlap peptide CB2-4 (117 residues) due to incomplete cleavage of a methionylthreonyl bond. The sum of the amino acid residues of the four major fragments matches the total number of amino acid residues of the native protein. The amino acid sequences of the cyanogen bromide fragments CB2, CB3, and CB4 were determined by a combination of automated and manual sequence analysis on peptides derived by chemical and enzymatic cleavage of the intact and the maleylated derivatives. The peptides were the products of cleavage by mild acid hydrolysis, trypsin, pepsin, chymotrypsin, thermolysin, and Staphylococcus aureus protease V8. The cyanogen bromide fragment CB1 was found to contain two unusual amino acids whose chemical structure will be presented in the following paper.
High-Temperature Cycling Performance of LiNi<sub>1/3</sub>Co<sub>1/3</sub>Mn<sub>1/3</sub>O<sub>2</sub>Cathode with DLC Protective Film (2014)

Diamond-like carbon film (DLC) is selected as a cathode-protective film because it has chemical inertness, mechanical hardness, and high electrical resistivity. For this study, a DLC protective film was deposited onto a cathode electrode rather than individual cathode particles. A hybrid process of plasma-based ion implantation and deposition was applied to a uniform deposition of the DLC protective film, even at low processing temperature on the cathode electrode having complex surface geometry and low melting point binder. The electrochemical performance of the DLC-coated LiNi1/3Co1/3Mn1/3O2 cathode was studied using galvano-static charge–discharge cycling at high operating temperature, compared to those of the pristine LiNi1/3Co1/3Mn1/3O2 cathode. The electrochemical stability of the DLC-coated electrode was discussed. The DLC film provides good protection against cathode/electrolyte interface degradation.
β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2 (2000)

Recently, a requirement for beta-arrestin-mediated endocytosis in the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) by several G protein-coupled receptors (GPCRs) has been proposed. However, the importance of this requirement for function of ERK1/2 is unknown. We report that agonists of Galphaq-coupled proteinase-activated receptor 2 (PAR2) stimulate formation of a multiprotein signaling complex, as detected by gel filtration, immunoprecipitation and immunofluorescence. The complex, which contains internalized receptor, beta-arrestin, raf-1, and activated ERK, is required for ERK1/2 activation. However, ERK1/2 activity is retained in the cytosol and neither translocates to the nucleus nor causes proliferation. In contrast, a mutant PAR2 (PAR2deltaST363/6A), which is unable to interact with beta-arrestin and, thus, does not desensitize or internalize, activates ERK1/2 by a distinct pathway, and fails to promote both complex formation and cytosolic retention of the activated ERK1/2. Whereas wild-type PAR2 activates ERK1/2 by a PKC-dependent and probably a ras-independent pathway, PAR2(deltaST363/6A) appears to activate ERK1/2 by a ras-dependent pathway, resulting in increased cell proliferation. Thus, formation of a signaling complex comprising PAR2, beta-arrestin, raf-1, and activated ERK1/2 might ensure appropriate subcellular localization of PAR2-mediated ERK activity, and thereby determine the mitogenic potential of receptor agonists.
Integrating color, texture, and geometry for image retrieval (2002)

This paper examines the problem of image retrieval from large, heterogeneous image databases. We present a technique that fulfils several needs identified by surveying recent research in the field. This technique fairly integrates a diverse and expandable set of image properties (for example, color, texture, and location) in a retrieval framework, and allows end-users substantial control over their use. We propose a novel set of evaluation methods in addition to applying established tests for image retrieval; our technique proves competitive with state-of-the-art methods in these tests and does better on certain tasks. Furthermore, it improves on many standard image retrieval algorithms by supporting queries based on subsections of images. For certain queries this capability significantly increases the relevance of the images retrieved, and further expands the user's control over the retrieval process.
ELECTROCUTANEOUS THRESHOLD CHANGES PRODUCED BY ELECTRIC SHOCK (1970)

ABSTRACT Three experiments were performed to investigate the effect of strong shock on absolute electrocutaneous thresholds. Experiment 1 confirms the existence of a reliable elevation of absolute threshold after strong shock. Experiment 2 shows the effect to be highly localized to the site of the strongly shocked electrode. It also shows that threshold elevation does not follow the same time course as do local vascular and impedance changes. Experiment 3 used skin treatment to alter the local vascular and impedance levels and demonstrated that threshold elevation occurs after strong shock even after these measures have been stabilized. These data indicate that the threshold increase due to electric shock is probably analogous to auditory fatigue but does not rule out the possible involvement of more central control factors.
The immunopathology of chronic experimental allergic encephalomyelitis induced in rabbits with bovine proteolipid protein. (1986)

The role of myelin proteolipid apoprotein (PLP) in the central nervous system (CNS) immune response of rabbits has been investigated by analyzing the immunopathology of chronic experimental allergic encephalomyelitis (EAE) induced by sensitization with PLP. Clinical disease occurred in seven out of nine rabbits sensitized with bovine PLP and monitored for up to 6 mo. Positive delayed hypersensitivity skin test reactions to PLP occurred in all but one of the PLP-sensitized animals. All PLP-sensitized animals had meningeal and CNS parenchymal inflammation that correlated with disease severity. Serial blood samples were stained with a panel of antibodies to rabbit T and B cells, as well as Ia, and large and small mononuclear cell populations were analyzed by flow cytometry. Peripheral leukocyte population staining did not correlate with clinical signs or sensitization to PLP. Cryostat CNS tissue sections were stained with the same set of antibodies by using an immunoperoxidase technique, and positive cells and vessels were counted. T cells and macrophages were numerous and in equal numbers in perivascular parenchymal inflammatory infiltrates, whereas B cells were less numerous (p less than 0.001). T cells also diffusely infiltrated the parenchyma. Most perivascular inflammatory cells and many scattered parenchymal cells were Ia+; Ia vascular expression was increased over controls (p less than 0.001), and also correlated with disease severity. The immunopathology of this chronic EAE model is the same as that of whole CNS tissue- and myelin basic protein-induced EAE in other species, and is similar to that of multiple sclerosis. Cellular immune responses to PLP may therefore contribute to systemic and in situ responses in CNS tissue demyelinating diseases.
Creating Vocational Curriculums for Youth Ministries: Challenges and Opportunities (2020)

This essay reflects on the creation of a vocational curriculum produced by the author's doctoral project. The goal is to explore the value in vocational reflection among teenagers in youth groups, and to offer an example of how youth ministries may implement extended and holistic teaching programs regarding the theology of vocation. This essay begins with an assessment of the ministry context. Second, It reviews templates for vocational curricula used on some college campuses and how the author implemented those strategies into the project. Two key strategies were a common curriculum and a mentoring environment. Such templates were found in the Programs for the Exploration of Vocation and the Network for Vocation in Undergraduate Education. Third, this essay examines particular opportunities present for youth ministries regarding vocation.
EBG Enhanced Feeds for the Improvement of the Aperture Efficiency of Reflector Antennas (2007)

We describe the use of electromagnetic bandgap (EBG) super-layers to improve the shape of reflectors illumination function. Following an investigation of the leaky wave pole singularities of the EBG Green's function, the shape of the radiation patterns of small apertures in ground planes are optimized. The maximization of the reflector aperture efficiency can be obtained by properly tuning the super layers geometrical parameters. A prototype of such feed has been designed, manufactured and tested. The results indicate that the inclusion of the EBG, increases the aperture efficiency of the feed+reflector system to values higher than 80%, over a 10% bandwidth. These low profile feeds are compatible with printed circuit board and/or integrated technology.
Virtual storage and virtual machine concepts (1972)

In this paper, we have discussed some of the salient aspects of virtual storage systems. Further, in the discussions of virtual machines and CP-67, we have illustrated an implementation of a virtual storage system as well as the generalization of the virtual storage concept to virtual machines. Although a virtual machine system does not within its strictly defined limits admit to the more complex uses of virtual storage, it does serve to illustrate the major problems confronted by many virtual storage systems. The utility of the virtual storage and machine concepts is wellestablished, and in the future, the application and extension of these concepts is certain to increase.
Mapping a domain specific language to a platform FPGA (2004)

A domain specific language (DSL) enables designers to rapidly specify and implement systems for a particular domain, yielding designs that are easy to understand, reason about, re-use and maintain. However, there is usually a significant overhead in the required infrastructure to map such a DSL on to a programmable logic device. In this paper, we present a mapping of an existing DSL for the networking domain on to a platform FPGA by embedding the DSL into an existing language infrastructure. In particular, we will show that, using few basic concepts, we are able to achieve a successful mapping of the DSL on to a platform FPGA and create a re-usable structure that also makes it easy to extend the DSL. Finally we will present some results of mapping the DSL on to a platform FPGA and comment on the resulting overhead.
Micromechanical triaxial acceleration sensor for automotive applications (2004)

A micromechanical triaxial acceleration sensor for automotive applications has been realised that has all three axis integrated into one single transducer element. Prototypes of the sensor were fabricated using a standard Bosch surface micromachining process. The active electromechanical transducer element requires less than 1 mm/sup 2/ of chip area. Open-loop capacitive readout is used to evaluate the sensor, which operates in a three-mass-oscillator configuration. X, Y and Z-axis sensitivities of 0.55 fF/G, 0.4 fF/G and 0.99 fF/G have been achieved.
Composition of waxes from crude rice bran oil (1982)

Abstract Hard and soft waxes were separated from the tank settling of crude rice bran oil by solvent extraction and analyzed for their composition by gas liquid chromatography (GLC). The results showed that the melting points of the hard wax and the soft wax were 79.5 C and 74 C, respectively, and that the hard wax was mainly composed of saturated fatty alcohols of C24, C26 and C30, saturated fatty acids of C22, C24 and C26, and n ‐alkanes of C29 and C31. The soft wax was mainly composed of saturated fatty alcohols of C24 and C30, saturated fatty acids of C16 and C26, and n ‐alkanes of C21 and C29. In the soft wax, lauric acid was also detected.