gebhart/patrepeval huggingface dataset:
Soluble bovine galactose-binding lectin. cDNA cloning reveals the complete amino acid sequence and an antigenic relationship with the major encephalitogenic domain of myelin basic protein (1989)

A full-length cDNA clone for the 13-14 kDa soluble beta-galactoside-binding lectin was isolated from a bovine fibroblast cDNA library. The derived amino acid sequence shows eight differences from a preliminary partial amino acid sequence given previously for the bovine heart lectin. This observation led to a re-examination of the data and correction of the heart lectin protein sequence. Except for a possible polymorphism of the heart lectin at position 57, the fibroblast and heart lectin sequences are considered identical. The epitope recognized by two monoclonal anti-(bovine lectin) antibodies, 36/8 and 9/5, was identified as the tetrapeptide sequence W-G-A/S-E/D by the isolation of several different cDNA clones from a human intestine cDNA library. A similar tetrapeptide is present in all of the soluble beta-galactoside-binding animal lectins sequenced thus far. It is also found in myelin basic protein, which we show is antigenically cross-reactive with the lectin. In myelin basic protein the tetrapeptide is a part of the major domain previously shown to be responsible for the induction of experimental allergic encephalomyelitis.
3',4',7,8-Tetrahydroxyflavone inhibits RANKL-induced osteoclast formation and bone resorption. (2017)

Osteoclasts, which are specialized bone multinuclear cells, are responsible for bone lytic diseases such as osteoporosis. 3',4',7,8-tetrahydroxyflavone is a flavonoid from Acacia confusa. In the present study, we found that 3',4',7,8-tetrahydroxyflavone markedly inhibited receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastic differentiation from mouse bone marrow-derived macrophages (BMMs). 3',4',7,8-tetrahydroxyflavone also reduced the mRNA expression levels of osteoclastic marker genes including the calcitonin receptor (CTR) and cathepsin K. In addition, 3',4',7,8-tetrahydroxyflavone decreased the bone resorption activity of osteoclasts on dentin slices. We found that 3',4',7,8-tetrahydroxyflavone inhibited RANKL-induced expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), a key transcription factor of osteoclast differentiation. Furthermore, ectopic overexpression of a constitutively active form of NFATc1 completely rescued the anti-osteoclastogenic effect of 3',4',7,8-tetrahydroxyflavone, suggesting that the anti-osteoclastogenic effect was mainly attributed to the reduction in NFATc1 expression. Taken together, our data suggest that 3',4',7,8-tetrahydroxyflavone inhibits osteoclast differentiation and bone loss and may therefore be considered a promising drug candidate for treating or preventing bone-lytic diseases.
Selecting good expansion terms for pseudo-relevance feedback (2008)

Pseudo-relevance feedback assumes that most frequent terms in the pseudo-feedback documents are useful for the retrieval. In this study, we re-examine this assumption and show that it does not hold in reality - many expansion terms identified in traditional approaches are indeed unrelated to the query and harmful to the retrieval. We also show that good expansion terms cannot be distinguished from bad ones merely on their distributions in the feedback documents and in the whole collection. We then propose to integrate a term classification process to predict the usefulness of expansion terms. Multiple additional features can be integrated in this process. Our experiments on three TREC collections show that retrieval effectiveness can be much improved when term classification is used. In addition, we also demonstrate that good terms should be identified directly according to their possible impact on the retrieval effectiveness, i.e. using supervised learning, instead of unsupervised learning.
Daylight demonstration of low-light-level communication system using correlated photon pairs (1991)

The authors demonstrate optical communication in free space at light levels much lower than that of ambient light. The method uses the highly time correlated nature of the photon pairs produced by non-degenerate parametric downconversion. Information was transmitted a distance of 200 m in daylight when the received signal intensity was only 0.14% of the detected background light level.
Suboptimal health: a new health dimension for translational medicine (2012)

SHSQ-25 could be used as a translational medicine instrument for health measuring in the general population.
Dielectric constant enhancement due to Si incorporation into HfO2 (2006)

The authors investigated the dielectric constant change of Hf(1−x)SixO2 film as functions of Si concentration and annealing temperature. As a result, the dielectric constant of Hf(1−x)SixO2 was increased when doped with a small amount of Si after 800°C annealing. The authors revealed that the dielectric constant enhancement of Hf(1−x)SixO2 films is related to the phase transformation from the monoclinic to the tetragonal phase of HfO2. By using the Clausius-Mossotti relation, it is concluded that the dielectric constant enhancement through the structural phase transformation is derived from the molar volume shrinkage rather than the molar polarizability increase.
Protein Biomarkers of Periodontitis in Saliva (2014)

Periodontitis is a chronic inflammatory condition of the tissues that surround and support the teeth and is initiated by inappropriate and excessive immune responses to bacteria in subgingival dental plaque leading to loss of the integrity of the periodontium, compromised tooth function, and eventually tooth loss. Periodontitis is an economically important disease as it is time-consuming and expensive to treat. Periodontitis has a worldwide prevalence of 5-15% and the prevalence of severe disease in western populations has increased in recent decades. Furthermore, periodontitis is more common in smokers, in obesity, in people with diabetes, and in heart disease patients although the pathogenic processes underpinning these links are, as yet, poorly understood. Diagnosis and monitoring of periodontitis rely on traditional clinical examinations which are inadequate to predict patient susceptibility, disease activity, and response to treatment. Studies of the immunopathogenesis of periodontitis and analysis of mediators in saliva have allowed the identification of many potentially useful biomarkers. Convenient measurement of these biomarkers using chairside analytical devices could form the basis for diagnostic tests which will aid the clinician and the patient in periodontitis management; this review will summarise this field and will identify the experimental, technical, and clinical issues that remain to be addressed before such tests can be implemented.
Studies of Dilithium Initiators. 5. 7Li NMR Analysis of Ionic Species (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies of Dilithium Initiators. 5. 7Li NMR Analysis of Ionic SpeciesA. L. Gatzke and D. Patrick GreenCite this: Macromolecules 1994, 27, 8, 2249–2255Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/ma00086a040https://doi.org/10.1021/ma00086a040research-articleACS PublicationsRequest reuse permissionsArticle Views99Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ciberagresión: una modalidad de ataque a periodistas digitales en Colombia (2020)

Comunicación y culturas mediáticas es un documento en el que se presentan resultados de investigación que relatan, desde la vivencia y creación de medios de comunicación, cómo lo es la radio universitaria. También se analiza la ciberagresión a periodistas como problemática actual, una propuesta en el uso de formatos radiofónicos; para luego pasar al análisis de tendencias de Twitter en eventos catastróficos, finalizando con lo estético y natural de propuestas artísticas nacionales.
A conference key distribution system (1982)

Encryption is used in a communication system to safeguard information in the transmitted messages from anyone other than the intended receiver(s). To perform the encryption and decryption the transmitter and receiver(s) ought to have matching encryption and decryption keys. A clever way to generate these keys is to use the public key distribution system invented by Diffie and Hellman. That system, however, admits only one pair of communication stations to share a particular pair of encryption and decryption keys, The public key distribution system is generalized to a conference key distribution system (CKDS) which admits any group of stations to share the same encryption and decryption keys. The analysis reveals two important aspects of any conference key distribution system. One is the multitap resistance, which is a measure of the information security in the communication system. The other is the separation of the problem into two parts: the choice of a suitable symmetric function of the private keys and the choice of a suitable one-way mapping thereof. We have also shown how to use CKDS in connection with public key ciphers and an authorization scheme.
High Strength Si<sub>3</sub>N<sub>4</sub> Ceramics (1989)

Si3N4 ceramics composed of fine-grained α′-Si3N4 and β′-Si3N4 were fabricated by hot-pressing mixtures of Si3N4, Y2O3 and AlN powders. The Si3N4 ceramics showed a very high strength (about 1.3GPa at room temperature and 1.0GPa at 1400°C) and a high fracture toughness (about 7.0MPa·m1/2).
Relative Reliability of the Auditory Evoked Potential and Bispectral Index for Monitoring Sedation Level in Surgical Intensive Care Patients (2008)

Sedation is an important adjunct therapy for patients in the intensive care unit. The objective of the present study was to observe correlation between an established subjective measure, the Ramsay Sedation Scale, and two objective tools for monitoring critically ill patients: the Bispectral Index (BIS) and auditory evoked potential. Ninety patients undergoing major surgery scheduled for postoperative mechanical ventilation and continuous sedation with propofol and fentanyl were selected. Electrodes for determining BIS and auditory evoked potential were placed on the foreheads of all patients according to manufacturer's specifications at least six hours after patients' arrival at the intensive care unit. Ramsay Sedation Scale, BIS, signal quality index, composite A-line autoregressive index (AAI) and electromyographic activities were recorded every five minutes for 30 minutes. BIS and AAI showed good correlation amongst readings (r(s)=0.697, P <0.01). Both were significantly influenced by electromyographic activities (BIS, r(s)=0.735, P <0.01; AAI, r(s)=0.856, P <0.01). Comparison of BIS and AAI revealed an acceptable correlation between electroencephalogram variables and the Ramsay Sedation Scale (BIS, tau=-0.689; AAI, tau=-0.621; P <0.01). In conclusion, the auditory evoked potential and BIS monitors revealed an acceptable correlation with the Ramsay Sedation Scale. However, the BIS and auditory evoked potential monitors do not perform adequately as a substitute in the assessment of sedated intensive care unit patients. These monitors could be used as part of an integrated approach for the evaluation of those patients especially when the subjective scales do not work well in the setting of neuromuscular blockade or may not be sufficiently sensitive to evaluate very deep sedation.
A new technique for automatic contour extraction (2002)

In working towards a three-dimensional (3-D) polygonal-based surgical planner, we developed an automatic contour extraction algorithm for Computed Tomography (CT) data. The contours were identified by using segmentation, region filling, boundary detection, and contour tracing. Our algorithm produced accurate, closed contours that were used to generate a 3-D polygonal mesh of a biomedical structure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Increased frequency of antigen-specific CD8+ cytotoxic T lymphocytes infiltrating an Epstein-Barr virus–associated gastric carcinoma (1999)

Gastric adenocarcinomas carrying Epstein-Barr virus (EBV) are known to be accompanied by massive lymphocyte infiltration. To characterize the tumor-infiltrating lymphocytes (TILs), we isolated and cultured such cells from a surgically resected EBV-associated gastric carcinoma. They were found to be positive for CD3, CD8, T-cell receptor beta chain, and cytotoxic molecules. The isolated TILs consisted of human leukocyte antigen (HLA) class I-restricted CD8(+) cytotoxic T lymphocytes (CTLs), which killed autologous EBV-transformed cells (but not phytohemagglutinin blast cells) and recognized HLA-A24 as restriction molecules. However, the TILs did not recognize known EBV antigenic peptides presented by HLA-A24 molecules, nor HLA-A24(+) fibroblasts infected with vaccinia recombinant virus expressing each of the EBV latent proteins. EBV(+) gastric carcinomas do not express conventional target proteins of EBV-specific CTLs, and the data suggest that some cellular proteins may be involved in the strong T-cell response to EBV-associated gastric carcinoma. In addition, our data suggest that class I-restricted, antigen-specific CD8(+) CTLs are specifically expanded within EBV(+) gastric carcinoma tissue.
miR-200–containing extracellular vesicles promote breast cancer cell metastasis (2014)

Metastasis is associated with poor prognosis in breast cancer patients. Not all cancer cells within a tumor are capable of metastasizing. The microRNA-200 (miR-200) family, which regulates the mesenchymal-to-epithelial transition, is enriched in the serum of patients with metastatic cancers. Ectopic expression of miR-200 can confer metastatic ability to poorly metastatic tumor cells in some settings. Here, we investigated whether metastatic capability could be transferred between metastatic and nonmetastatic cancer cells via extracellular vesicles. miR-200 was secreted in extracellular vesicles from metastatic murine and human breast cancer cell lines, and miR-200 levels were increased in sera of mice bearing metastatic tumors. In culture, murine and human metastatic breast cancer cell extracellular vesicles transferred miR-200 microRNAs to nonmetastatic cells, altering gene expression and promoting mesenchymal-to-epithelial transition. In murine cancer and human xenograft models, miR-200-expressing tumors and extracellular vesicles from these tumors promoted metastasis of otherwise weakly metastatic cells either nearby or at distant sites and conferred to these cells the ability to colonize distant tissues in a miR-200-dependent manner. Together, our results demonstrate that metastatic capability can be transferred by the uptake of extracellular vesicles.
Excited State Intramolecular Proton Transfer and Charge Transfer Dynamics of a 2-(2′-Hydroxyphenyl)benzoxazole Derivative in Solution (2010)

Excited state intramolecular proton transfer (ESIPT) and subsequent intramolecular charge transfer (ICT) dynamics of a 2-(2'-hydroxyphenyl)benzoxazole derivative conjugated with an electron withdrawing group (HBOCE) in solutions and a polymer film has been investigated by femtosecond time-resolved fluorescence (TRF) and TRF spectra measurements without the conventional spectral reconstruction method. TRF with high enough resolution (<100 fs) reveals that the ESIPT dynamics of HBOCE in liquids proceeds by at least two time constants of approximately 250 fs and approximately 1.2 ps. The relative amplitude of the slower picosecond component is smaller in the polymer film than that in solution. Conformational heterogeneity in the ground state originating from the dispersion of the dihedral angle between the phenolic and benzoxazole groups is invoked to account for the dispersive ESIPT dynamics in liquids. From the TRF spectra of both the enol and keto isomers, we have identified the ICT reaction of the keto isomer occurring subsequent to the ESIPT. The ICT proceeds also by two time constants of near instantaneous and 2.7 ps. Since the ICT dynamics of HBOCE is rather close to the polar solvation dynamics, we argue that the ICT is barrierless and determined mostly by the solvent fluctuation.
iMACSIM: a program for multi-level analog circuit simulation (2002)

The authors describe a new program called iMACSIM which allows multi-level, mixed-domain simulation of analog integrated circuits. The program performs the simulation of different subcircuits at the behavioral, functional, and electrical levels concurrently. It also enables some parts of the circuit to be simulated using discrete-time algorithms while other portions are processed by continuous-time techniques. Simulations are presented to demonstrate the functionality of the program.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Verifying computations with state (2013)

When a client outsources a job to a third party (e.g., the cloud), how can the client check the result, without re-executing the computation? Recent work in proof-based verifiable computation has made significant progress on this problem by incorporating deep results from complexity theory and cryptography into built systems. However, these systems work within a stateless model: they exclude computations that interact with RAM or a disk, or for which the client does not have the full input.
Enzyme therapy XIV. Comparison of methods for enzyme entrapment in human erythrocytes. (1980)

Seven methods of erythrocyte entrapment--six by hypotonic exchange loading and one by chlorpromazine-induced endocytosis--were evaluted for (1) efficiency of incorporation of beta-glucuronidase, inulin, and glucose; (2) presence of beta-glucuronidase on the erythrocyte surface, as detected by hemagglutination or complement-dependent lysis in the prsence of antibody to beta-glucuronidase; (3) in vitro leakage of entrapped markers; and (4) morphologic alterations by scanning electron microscopy. Dependent on the method of entrapment, the incorporation of markers ranged from 0.7% to 6.2% for beta-glucuronidase, 3.4% to 31% for inulin, and 1.2% to 12.2% for glucose. Maximal incorporation by hypotonic exchange loading occurred when the initial concentration of sodium chloride (150 mM) was reduced to 50 or 75 mM. However, beta-glucuronidase was detected on the erythrocyte surface by hemagglutination for these methods as well as a dialysis method of loading. Essentially no leakage of entrapped enzyme was detected (< 1%) for all methods, although up to 11% of entrapped glucose was released during a 3 hr incubation at 37 degrees C in buffered whole blood. Finally, entrapment methods requiring the greatest reduction in salt concentration resulted in the formation of echinocytes, whereas stomatocytes were observed after entrapment by methods requiring lesser salt dilutions. These results demonstrate the efficiency of entrapment and relative integrity of erythrocytes following various loadng procedures and suggest that in vitro assessment may provide a useful predictor of the imunogenicity and in vivo fate of erythrocyte-entrapped enzymes or other therapeutic agents.
Platelet‐Rich Plasma: Growth Factors and Pro‐ and Anti‐Inflammatory Properties (2007)

PRP is a rich source of growth factors and promoted significant changes in monocyte-mediated proinflammatory cytokine/chemokine release. LXA(4) was increased in PRP, suggesting that PRP may suppress cytokine release, limit inflammation, and, thereby, promote tissue regeneration.
Performance of complex queries in Main Memory Database Systems (1987)

Memory residence can buy both functionality and performance for a database management system. In this paper, we present a description and a benchmark of an experimental implementation of a Main Memory Database System (MMDBS) that was designed to support complex interactive queries. We describe and evaluate the main memory database structures and query processing algorithms implemented in this prototype. Our measurements and analysis, focused on aggregates and joins, include both memory requirements and response time, since there is a clear trade-off between space and time in the design of a MMDBS. In contrast to conventional Disk-based Database Systems (DDBS's), we found that an MMDBS can efficiently execute complex relational queries. We identify strategies that exploit memory residence effectively. We also identified a number of performance problems related to query optimization in main memory and memory management for MMDBS's.
<title>Chemically Vapor-Deposited Zinc Sulfide Infrared Windows: Optical Properties And Physical Characteristics</title> (1980)

In recent years, work on chemically vapor-deposited zinc sulfide (CVD ZnS) has resulted in the development of a material that shows much promise for infrared systems applications involving windows (or domes) and operating in the 8- to 12-μm region. This paper summarizes measurements and calculations carried out in the context of assessing relevant features of CVD ZnS, particularly with regard to: (a) Spectral Transmittance /Emittance. We show that CVD-ZnS windows capable of satisfying structural requirements stemming from the mechanics of high-speed flight exhibit transmittance and emittance characteristics which do not seriously affect the system sensitivity, over the range of anticipated thermal loads. And (b) Image Spoiling Properties. Line-spread function data demonstrate that small-angle scattering, index inhomogeneities, and other potential image-spoiling features do not inject any detectable degradation in system MTF, at spatial frequencies of interest for high-resolution thermal imaging.
Low Velocity Sphere Impact of Soda Lime Silicate Glass (2012)

This chapter contains sections titled: Introduction Experimental Procedure Results and Discussion Summary and Conclusions Acknowledgements