gebhart/patrepeval huggingface dataset:
Mitochondrial disease: genetics and management (2015)

Mitochondrial disease is one of the most common groups of genetic diseases with a minimum prevalence of greater than 1 in 5000 in adults. Whilst multi-system involvement is often evident, neurological manifestation is the principal presentation in most cases. The multiple clinical phenotypes and the involvement of both the mitochondrial and nuclear genome make mitochondrial disease particularly challenging for the clinician. In this review article we cover mitochondrial genetics and common neurological presentations associated with adult mitochondrial disease. In addition, specific and supportive treatments are discussed.
Architectural support for convolutional neural networks on modern CPUs (2018)

A key focus of recent work in our community has been on devising increasingly sophisticated acceleration devices for deep neural network (DNN) computation, especially for networks driven by convolution layers. Yet, despite the promise of substantial improvements in performance and energy consumption offered by these approaches, general purpose computing is not going away because its traditional well-understood programming model and continued wide deployment. Therefore, the question arises as to what can be done, if anything, to evolve conventional CPUs to accommodate efficient deep neural network computation.
Newly-Designed Fault Diagnostic Method for Solar Photovoltaic Generation System Based on IV-Curve Measurement (2019)

Fault diagnosis of photovoltaic (PV) arrays is an essential task for improving the reliability and safety of a photovoltaic system (PVS). The PVS faults at the DC side are difficult to detect by traditional protective devices, which may reduce power conversion efficiency and even lead to safety matters and fire disaster. This study investigates a newly-designed fault diagnostic method for a PVS according to the following three steps. First, optimal fault features are extracted by analyzing I-V curves from different faults, including hybrid faults of the PVS under the standard test condition (STC). Moreover, the trust-region-reflective (TRR) deterministic algorithm combined with the particle-swarm-optimization (PSO) metaheuristic algorithm is proposed to standardize fault features into the ones under the STC. In addition, a multi-class adaptive boosting (AdaBoost) algorithm, which is the stage-wise additive modeling using multi-class exponential (SAMME) loss function based on the classification and regression tree (CART) as the weak classifier, is utilized to establish the fault diagnostic model. The effectiveness of the fault diagnostic model could long-term maintain by periodically updating the feature standardization equations to standardize the fault features into the ones under the STC. Various types of the PV modules are used to validate the generalization of the fault diagnostic method. Both the numerical simulations and experimental results show the accuracy and reliability of the proposed fault diagnostic method.
In-orbit Spacecraft Manufacturing: Near-Term Business Cases Individual Project Report (2016)

The recent developments in space commercialization and the entry of new private entities of various size has re-opened the question of in-space manufacturing. This report examines the viability of a broad set of initial use cases for in-orbit manufacturing around the Earth in particular, involving technologies with a time horizon of 3-5 years. These include large aperture spacecraft or components, components for traditional satellites, standards-based components and nano-satellites such as cubesats, and serial production commercial satellite use cases among others. The definition of manufacturing used extends to any activity involving some or all of three main parts of the value chain including fabrication, assembly, and integration. It also covers cases where testing, deployment, maintenance, repair, upgrades, recycling, and re-deployment have significant inclusion related to the mentioned areas. Pre-fabrication and 3D printing of components in orbit are considered across a number of sub-systems, including solar panels, support structures and truss elements, communication antennae, mirrors, radiation panels and other thermal components, propulsion and fuel elements, and standardized electronics, among others. A classification, evaluation, and selection methodology is provided. The initial broad set of use cases is analyzed and filtered based on factors such as technical feasibility, technology readiness level, potential market, costs, trade-offs and alternatives, and long term use case sustainability. The resulting short list is treated to a preliminary high-level business case analysis and existing project case studies are examined. Lastly, recommendations on the prospects for further investigation are provided.
Preparation and characterization of fluorine‐containing aromatic condensation polymers, 4. Preparation and characterization of fluorine‐containing aromatic polyazomethines and copolyazomethines from perfluoroisopropylidene group‐containing aromatic diamines and/or isopropylidene group‐containing aromatic diamines and phthaladehydes (1994)

Abstract A series of novel fluorine‐containing aromatic homopolyazomethines and copolyazomethines were synthesized by solution polycondensation of perfluoroisopropylidene (perfluoropropane‐2,2‐diyl) group‐containing aromatic diamines, 2,2‐bis[4‐(4‐aminophenoxy)phenyl]‐1,1,1,3,3,3‐hexafluoropropane (4,4′‐[1,1,1,3,3,3‐hexafluoropropane‐2,2‐diylbis(1,4‐phenyleneoxy)]dianiline ( 1a )) and 2,2‐bis(4‐aminophenyl)‐1,1,1,3,3,3‐hexafluoropropane (4,4′‐(1,1,1,3,3,3‐hexafluoropropane‐2,2‐diyl)dianiline ( 1b )), and/or the corresponding analogous isopropylidene group‐containing aromatic diamines, 2,2‐bis[4‐(4‐aminophenoxy)phenyl]propane (4,4′‐[isopropylidenebis(1,4‐phenyleneoxy)]dianiline ( 1c )) and 2,2‐bis(4‐aminophenyl)propane (4,4′‐isopropylidenedianiline ( 1d )), with terephthalaldehyde ( 2a ) and isophthaladehyde ( 2b ). The effect of fluorine substitution on the synthesis and properties of these polymers was investigated by comparison with those of the corresponding homopolyazomethines but without fluorine. Film‐forming fluorine‐containing polyazomethines with reduced viscosities up to η red = 0,44 dL · g −1 were obtained in high yields by using m ‐cresol as reaction medium. Incorporation of perfluoroisopropylidene groups in the polyazomethine backbone greatly enhanced the solubility of the polymers in various organic solvents including chloroform and tetrahydrofuran. Their thermal stability was also successfully improved by the introduction of fluorine, and both the temperatures of 5% and 10% weight loss in air increased monotonically with the increase of the fluorine content. The surface properties of the films or the contact angles formed by water and diiodomethane were, however, scarcely affected by fluorine substitution. The mechanical properties of the films, such as tensile strength and initial modulus, fairly decreased by the modification.
Design and implementation of a high-efficiency on- board battery charger for electric vehicles with frequency control strategy (2010)

This paper presents a design and implementation of 3.3 kW on-board battery charger for electric vehicles or plug-in hybrid electric vehicles. A series-loaded resonant dc-dc converter and frequency control are adopted in consideration of efficiency, reliability, volume, cost, and so on. In order to obtain high efficiency and less volume within 6 liters, a prototype of the charger is designed and implemented by using high frequency of 80-130 kHz and zero voltage switching method. The experimental result indicates 93% of the maximum efficiency and 5.84 liters in volume of the developed 3.3 kW on-board battery charger.
Rapid Identification of International Multidrug-Resistant Pseudomonas aeruginosa Clones by Multiple-Locus Variable Number of Tandem Repeats Analysis and Investigation of Their Susceptibility to Lytic Bacteriophages (2012)

The objective of this study was to determine the genetic diversity of multidrug-resistant (MDR) Pseudomonas aeruginosa strains isolated over a period of 12 months in two French hospitals and to test their susceptibility to bacteriophages. A total of 47 MDR isolates recovered from hospitalized patients were genotyped using multiple-locus variable number of tandem repeats analysis. The genotypes were distributed into five clones (including 19, 5, 5, 3, and 3 isolates, respectively) and 12 singletons. Comparison to 77 MDR strains from three other countries, and MLST analysis of selected isolates showed the predominance of international MDR clones. The larger clone, CC235, contained 59 isolates displaying different antibiotic resistance mechanisms, including the presence of the GES1, VIM-2, VIM-4, and IMP-1 β-lactamases. Three newly isolated P. aeruginosa bacteriophages were found to lyse 42 of the 44 analyzed strains, distributed into the different clonal complexes. This pilot study suggests that systematic genotyping of P. aeruginosa MDR strains could improve our epidemiological understanding of transmission at both the local (hospital) and the national level and that phage therapy could be an alternative or a complementary treatment to antibiotics for treating MDR-infected patients.
Total internal diffraction of plasmon surface polaritons (1987)

Total internal diffraction of plasmon surface polariton fields by a dielectric phase grating is described. The grating was fabricated by partly desorbing thin organic multilayers deposited on top of the plasmon-carrying Ag-air interface through the regularly spaced holes of an electron microscope grid. The diffraction pattern shows for various angles of incidence a characteristic intensity distribution which can be understood taking into account a grating wave vector mediated coupling of the two plasmons corresponding to the two different layer structures.
Modeling pre-existing immunity to adenovirus as a method to identify novel formulations for a protective Ebola vaccine (2012)

Mucosal delivery of recombinant adenovirus serotype 5 (rAd5)-based vaccine preparations are appealing for vaccine development in terms of lowering toxicity induced by high viral loads and substantial liver accumulation following systemic injection of the vaccine. However, this mode of delivery is currently under-developed due to the relatively low T-cell mediated immune responses generated against the encoded transgene. The first study described in this thesis demonstrated that sublingual immunization induces rapid migration of MHCII+, CD11C+ antigen presenting cells to the delivery site and elicit antigen-specific T and B cell-mediated immune responses in naive mice and those with pre-existing immunity (PEI) to Ad5 at a level higher than that achieved after oral immunization. More importantly, this strategy improved protection of animals with PEI to Ad in contrast to poor protection after IM injection. The second study was designed to establish a method for inducing PEI that most accurately reflects natural infection in rodents and identifies the immunologic parameters elicited by rAd5-based Ebola vaccine necessary for protection against lethal infection. When immunization occurred by the same route in which PEI was induced, the antigen-specific multifunctional CD8+ T cell and antibody responses were significantly reduced. This correlated with poor survival after challenge with a lethal dose of Ebola Zaire in rodents. The data suggests that 1) establishment of PEI by the same route used for immunization is the most stringent test for a novel formulation designed to be effective in those with PEI to Ad5, and 2) for a formulation to be effective in those with PEI, it must be capable of restoring antigen-specific multifunctional CD8+ T cell and antibody responses, compromised by PEI. The third study screened novel formulations for their ability to improve in vitro transduction efficiency and immunogenicity and efficacy in vivo in the presence of anti-Ad5 neutralizing antibodies. Formulations consisting of pharmaceutically acceptable, non-immunogenic excipients that can prime the arms of immune response compromised by PEI improved survival after lethal challenge with Ebola Zaire challenge for rAd5-based Ebola vaccine in rodents with PEI. Taken together, these studies provide insight on how to reconstitute necessary immune responses in vaccine protocols by establishing a reliable PEI model in rodents, testing routes of administration, and formulations of the rAd5-based Ebola vaccine.
Proteomic and phototoxic characterization of melanolipofuscin: correlation to disease and model for its origin. (2007)

Our results provide significant insight into understanding the formation and toxicity of MLF and suggest a possible contribution to the etiology of retinal diseases.
High‐pressure Self‐Combustion Sintering for Ceramics (1984)

The high‐pressure self‐combustion sintering process can be used to synthesize and simultaneously sinter ceramics in a very short time by taking advantage of exothermic reactions under high pressure. A dense TiB 2 compact was fabricated in a few seconds by electric ignition on one end of a powdered mixture of Ti and B under 3 GPa.
Dielectric anomalies near the Anderson metal-insulator transition (1982)

The linear-response expressions for the dielectric constant and conductivity as functions of wave number and frequency are evaluated near the localization metal-insulator transition for noninteracting quasiparticles. New behavior is found in the microscopic range. The static dielectric constant from the insulating side is found to diverge with twice the exponent characterizing the vanishing of the conductivity from the metallic side. The dynamic structure factor follows easily from our expressions and we suggest that it can be measured, in principle, using high-frequency electromagnetic radiation.
The papyrus integrated data server (2002)

Summary form only given. The authors focus on the performance of integrated specialized data managers. In particular, they focus on the customizations of parallel executions of data manager operators in a variety of computer configurations. This is done by specifying the glue that connects data manager operators in a way that is independent of the computer configuration; and then providing the ability to transparently target the execution to a variety of computer configurations. Parallelization of data manager operators built using Papyrus services is a challenging problem, but a more challenging problem is the parallelization of data manager operators that are built independently of Papyrus and are therefore black boxes to Papyrus. Papyrus is a set of modules and services that enables the parallelization and integration of specialized data managers into one execution environment. Papyrus programs can be transparently targeted to different hardware configurations and can dynamically adjust at runtime to the number of available resources. A Papyrus System consists of a number of clients interfacing to a Papyrus Server. The Server consists of several integrated data managers executing on a multiprocessor system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Introduction to Programming in C (2010)

This introduction to "C" programming takes a single general application and extends it to introduce new concepts, progressing from a simple programme to a complete menu driver system with file handling routines. The text emphasizes the importance of producing well-structured and efficient software and uses graded programme examples throughout which
Low-Voltage Organic Field Effect Transistors with a 2-Tridecyl[1]benzothieno[3,2-<i>b</i>][1]benzothiophene Semiconductor Layer (2012)

An asymmetric n-alkyl substitution pattern was realized in 2-tridecyl[1]benzothieno[3,2-b][1]benzothiophene (C(13)-BTBT) in order to improve the charge transport properties in organic thin-film transistors. We obtained large hole mobilities up to 17.2 cm(2)/(V·s) in low-voltage operating devices. The large mobility is related to densely packed layers of the BTBT π-systems at the channel interface dedicated to the substitution motif and confirmed by X-ray reflectivity measurements. The devices exhibit promising stability in continuous operation for several hours in ambient air.
Carbocationic Polymerization in the Presence of Sterically Hindered Bases. III. The Polymerization of Isobutylene by the Cumyl Chloride/BCl<sub>3</sub>System (1982)

Abstract The mechanism of cationic olefin polymerization has been investigated by studying the effect of 2,6-di-tertbutylpyridine (DtBP) on the polymerization of isobutylene by the C6H5C(CH3)2Cl/BCl3 initiating system. In the absence of DtBP, initiation is by cumylation, chain transfer to monomer is absent, and termination is by chlorination. In the presence of DtBP, conversions and molecular weights decrease as a function of DtBP concentration, indicating that while DtBP does not interfere with nonprotic initiation by the C6H5C⊕(CH3)2 carbocation, it functions as a terminating agent. According to Mayo plots, chain transfer to monomer is absent with or without DtBP in the system; however, the ratio kt/kp (the slope of the plot) obtained in the presence of DtBP is ∼25 times larger than that obtained in the absence of this hindered base which also indicates termination by DtBP. The exclusive presence of CH2[dbnd]C(CH3) ∼ endgroups in polyisobutylene prepared in the presence of DtBP suggests that this base is able to abstract a proton from the propagating ∼C⊕(CH3)2 center. In contrast, according to initiator efficiency data, DtBP does not abstract a proton from the initiating C6H5C⊕ (CH3)2 cation.
Code Designs for MIMO Broadcast Channels (2006)

Recent information-theoretical results show the optimality of dirty-paper coding (DPC) in achieving the capacity of the Gaussian multiple-input multiple-output (MIMO) broadcast channel (BC). This paper presents the first practical limit approaching DPC-based design for the MIMO BC. We start with Cover's simplest two-user Gaussian BC and present a code design that operates 1.44 dB away from the capacity region boundary at a transmission rate of 1.0 bit per sample (b/s). Then we consider the non-degraded two-user MIMO fading BC with two transmit antennas. For this setup, the performance loss of our code design is 3.7 dB and 2.45 dB from the the sum-rate capacity when the transmission rate for each user is 1.0 b/s and 2.0 b/s, respectively.
Expanding the notion of links (1989)

Article Free Access Share on Expanding the notion of links Author: S. J. DeRose Summer Institute of Linguistics, 7500 W. Camp Wisdom Road, Dallas, TX Summer Institute of Linguistics, 7500 W. Camp Wisdom Road, Dallas, TXView Profile Authors Info & Claims HYPERTEXT '89: Proceedings of the second annual ACM conference on HypertextNovember 1989 Pages 249–257https://doi.org/10.1145/74224.74245Online:01 November 1989Publication History 78citation807DownloadsMetricsTotal Citations78Total Downloads807Last 12 Months10Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Modeling the Solvent Sphere:  Mechanism of the Shilov Reaction (1996)

Quantum chemical studies suggest that the Shilov reaction, the activation of alkane CH bonds by Pt salts in aqueous acid solution, goes via transfer of a hydrogen atom from a methane σ complex to a neighboring Cl ligand in what is best described as a σ bond metathesis. This avoids the formation of Pt(IV) and is quite similar to the mechanism proposed by Shilov himself. The hydrogen atom being transferred is not very protonic which is best seen by the fact that the transition state is not stabilized by additional water molecules in the bond breaking region, which would be expected to hydrogen bond to any protonic hydrogen. The calculated activation energy, with contributions from temperature and long-range dielectric effects, is in very good agreement with the experimental estimate. An alternative oxidative addition/reductive elimination sequence was found to be competitive for Pt. For Pd, the transition state energy for this pathway is much higher than for σ bond metathesis, and oxidative addition can therefore be disregarded. Although a σ bond metathesis mechanism seems more likely for Shilov chemistry with Pt, an oxidative addition/reductive elimination sequence cannot be safely excluded in the Pt case. The second coordination sphere of the solvent is found to play an important role in the Shilov reaction, both as ultimate proton acceptor from the methane and also in the energetics of methane binding; the latter directly contributes to the overall activation energy. The presence of only a few waters in the computational model allows these effects to be studied. The origin of the unusual preferential attack on primary versus secondary CH bonds in the system has been traced to the higher polarity of the n-alkyl versus the isoalkyl bond formed in the σ bond metathesis step.
Bandwidth characteristics of optical transmission line constructed with short-length optical fibers (1986)

This paper clarifies the bandwidth characteristics of a VAD-fabricated optical line constructed with short-length optical fibers. The refractive index profiles of these optical fibers are slightly distorted from the ideal profile. Their bandwidth characteristics are calculated and measured under the overfill mode distribution (OMD) and the equilibrium mode distribution (EMD) excitations. As a result, some of the optical fibers are shown to have extremely narrow bandwidths at the short fiber length under OMD excitation as compared with those under EMD excitation. The concatenation factor of the optical line consequently becomes a smaller value than that of an optical line constructed with long-length optical fibers. In addition, the measurement results of the optical subscriber transmission line field trial are shown to be in good agreement with those obtained in this paper.
Team Leadership Effectiveness in Technology-Based Project Environments (2004)

Managerial leadership and the organizational environment must be conducive to the professional needs of the project team. I reached this conclusion after conducting a field study of 80 technology-intensive project teams in 27 companies. This paper aims to improve the project management field's understanding of team performance as it is influenced by the organizational environment and managerial leadership. The results of this research suggest that many of the factors that drive project team performance, such as commitment and the ability to deal with conflict and risk, originate in the work environment. While effective management of the technical aspects of the project is critical to success, team leaders must also pay close attention to managing relations across the entire work process, including support functions, suppliers, sponsors, and partners. In this paper, I discuss the implications of — and criteria for — effective team leadership.