gebhart/patrepeval huggingface dataset:
Comparative studies of inhibitory activities of chalcones on tomato ringspot virus (ToRSV) (1997)

(1997). Comparative studies of inhibitory activities of chalcones on tomato ringspot virus (ToRSV) Canadian Journal of Plant Pathology: Vol. 19, No. 2, pp. 133-137.
Extracting symbolic rules from trained neural network ensembles (2003)

Neural network ensemble can significantly improve the generalization ability of neural network based systems. However, its comprehensibility is even worse than that of a single neural network because it comprises a collection of individual neural networks. In this paper, an approach named REFNE is proposed to improve the comprehensibility of trained neural network ensembles that perform classification tasks. REFNE utilizes the trained ensembles to generate instances and then extracts symbolic rules from those instances. It gracefully breaks the ties made by individual neural networks in prediction. It also employs specific discretization scheme, rule form, and fidelity evaluation mechanism. Experiments show that with different configurations, REFNE can extract rules with good fidelity that well explain the function of trained neural network ensembles, or rules with strong generalization ability that are even better than the trained neural network ensembles in prediction.
Opportunistic Feedback and Online Optimization for Multiuser MIMO Systems with Linear Receivers (2006)

This paper proposes a scheduling and feedback strategy for the multiuser multiple input multiple output (MIMO) downlink. The base station uses a per-antenna scheduling that maps each transmit antenna to a different user in the downlink. The scheduling is performed based on the channel information obtained via a contention based feedback mechanism. Two design parameters, i.e., a channel quality threshold and a feedback probability, are proposed to adjust the scheduling and feedback behavior of this system. They are updated through a novel online updating procedure using empirically observed distribution information. The main advantages of the proposed protocol are that it substantially reduces the feedback requirements, still achieves multiuser diversity gain, and provides some fairness without a priori assumptions about the channel distribution.
SympGraph (2012)

As an integral part of Electronic Health Records (EHRs), clinical notes pose special challenges for analyzing EHRs due to their unstructured nature. In this paper, we present a general mining framework SympGraph for modeling and analyzing symptom relationships in clinical notes.
Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs (1987)

Abstract The capacity of platelets to generate thromboxane A2, reflected by measurement of serum thromboxane B2 (TxB2), greatly exceeds the systemic production of thromboxane in vivo. Thus, it is possible that substantial but incomplete inhibition of thromboxane formation ex vivo would still allow marked augmentation of thromboxane production in vivo. To address this hypothesis, we administered aspirin 120 mg, a selective inhibitor of thromboxane synthase (TxSl), 3-(1H-imidazol-1-yl- methyl)-2-methyl-1H-indole-1-propanoic acid (UK-38, 485) 200 mg, and a combination of both drugs to 12 healthy volunteers and measured the effects on serum TxB2 and urinary 2,3-dinor-thromboxane B2 (Tx-M), an index of endogenous thromboxane biosynthesis. Although serum TxB2 was maximally inhibited by 94 +/- 1% after aspirin and 96 +/- 2% after the TxSl, maximal depression of Tx-M was only 28 +/- 8% and 37 +/- 9%, respectively. Combination of aspirin with the TxSl resulted in a small but significant increase in inhibition of thromboxane generation ex vivo (98 +/- 1% v 94 +/- 1%; P less than 0.05), but a disproportionately greater fall in thromboxane synthesis in vivo (58 +/- 7%; P less than 0.01). Consistent with further inhibition of platelet thromboxane synthesis, addition of the TxSl abolished the transient decline in prostacyclin formation after aspirin alone. Administration of a lower dose of aspirin (20 mg) to 6 healthy subjects caused a small reduction in Tx-M (12 +/- 4%; P less than 0.05) and inhibited serum TxB2 by 48 +/- 2%. The relationship between inhibition of platelet capacity to form thromboxane ex vivo (serum TxB2) and synthesis in vivo (Tx-M) departed markedly from the line of identity. When total blockade of the capacity of platelets to generate thromboxane is approached, minor decrements in capacity result in a disproportionate depression of actual thromboxane biosynthesis. These results imply that pharmacologic inhibition of serum TxB2 must be virtually complete before thromboxane- dependent platelet activation is influenced in vivo.
Development and Analysis of Cement-Coated Aggregates for Asphalt Mixtures (1992)

Aggregate quality has a central role in the performance of hot mix asphalt concrete (HMAC) mixtures. The availability of good quality aggregates is of concern in many countries including the U.S.A. One of the solutions to the aggregate depletion problem is to upgrade and improve the properties of the available abundance of marginal aggregates. This paper introduces a new aggregate upgrading technique for the use in HMAC mixtures. The proposed technique is referred to as “Cement Coating Technique” (CCT). The CCT addresses the surface texture of aggregate particles and improves the bond between the particle surface and the asphalt binder. The concept of the CCT is based on shielding the surface of the aggregate particles by a hydrated Portland cement film. The new cement coated aggregates can then be used in asphalt mixtures following the usual mix procedures. Asphalt concrete mixes made with cement coated aggregates are referred to as “CEMPHALT” mixtures. Cement content, water cement ratio and hydration time were found to be the three main parameters influencing the coating process. The optimum values of these parameters were determined. Performanceevaluation of CEMPHALT mixtures indicated significant improvements achieved in permanent deformation, fatigue and moisture damage resistance.
Viscosities of fatty acids, triglycerides, and their binary mixtures (1997)

Abstract Viscosity data have been obtained as a function of temperature for seven fatty acids (pelargonic, capric, lauric, myristic, palmitic, stearic, and oleic) and four triglycerides (tricaprilin, tripalmitin, tristearin, and triolein) and their binary mixtures at temperatures from above their melting points to 90°C. The viscosity measurements were performed by using Cannon Fenske glass capillary kinematic viscometers. Modified versions of the Andrade equation were used to correlate the kinematic viscosities of pure fatty acids and pure triglycerides. The MacAllister method was used for their binary mixtures. The correlation constants are valuable for designing or evaluating chemical process equipment, such as heat exchangers, reactors, distillation columns, and process piping.
Temperature dependence of the 90° coupling in Fe/Al/Fe(001) magnetic trilayers (1993)

The temperature dependence of the unusual magnetic 90° coupling in epitaxial Fe/Al/Fe(001) trilayers has been determined. For specific values of applied field and temperature, in-plane anisotropy and the interlayer coupling drive abrupt first-order changes in the temperature-dependent moment of these trilayers. The occurrence of such a first-order transition can be used to determine the value of the interlayer coupling constant, JQ, at the transition temperature. We show that Fe/Al/Fe(001) trilayers also exhibit distinct second-order transitions in the temperature-dependent moment, and that the occurrence of a second-order transition can similarly be used to specify JQ(T). A comparison is made of the values of JQ(T) determined by these two approaches, and the dependence of JQ on T is analyzed.
Characterization of the interaction between hepatitis C virus NS5B and the human oestrogen receptor alpha (2011)

The RNA-dependent RNA polymerase (NS5B) of hepatitis C virus (HCV) is part of the viral replicative complex and plays a crucial role in HCV replication. It has been described that NS5B interacts with cellular proteins, and that interactions between NS5B and host proteins are crucial for viral replication. Some of the host factors involved in the HCV replication cycle include the oestrogen receptor alpha (ESR1), protein kinases (c-Src) and chaperones (Hsp70). In this report, we determine the requirements for the interplay between NS5B and the domain C of ESR1 (ESR1C) by using Förster Resonance Energy Transfer. NS5B-ESR1C and ESR1C-ESR1C interactions are dependent on ionic strength, indicating that contacts are mainly electrostatic. Additionally, NS5B residues involved in NS5B oligomerization were also essential for NS5B-ESR1C interaction. The study of the interactions among viral and host factors will provide data to establish innovative therapeutic strategies and the development of new antiviral drugs.
User's guide to designing and mounting lenses and mirrors (1978)

The guidebook is a practitioner-oriented supplement to standard texts in optics and mechanical engineering. It reflects practical experience with the oftentimes troublesome aspects of effectively integrating optical components with mechanical hardware. Accordingly, its focus is on the techniques, assumptions, and levels of design sophistication needed for a wide variety of sizes and optical surface quality levels. It is intended to be a primer for engineers, designers, and draftsmen already familiar with some of the problems encountered in mounting optical components and who are responsible for developing components for high-energy laser systems.
Reservoir of four organisms associated with bacterial vaginosis suggests lack of sexual transmission (1990)

This study consisted of a search for the possible reservoir and mode of spread of the four bacterial vaginosis-associated organisms Mobiluncus mulieris, Mobiluncus curtisii, Mycoplasma hominis, and Gardnerella vaginalis. Their occurrence in rectal, oral, and pharyngeal specimens from women with and without bacterial vaginosis, their male sexual consorts, four homosexual men, and children (altogether, 374 people) was studied. Genital samples were also obtained from all adults. All four organisms were isolated from the rectums of 45 to 62% of women with bacterial vaginosis and 10 to 14% of women without bacterial vaginosis. They also occurred in the rectums of males and children. M. hominis was recovered from the oropharynxes of 12 adults whose sexual consorts had genital occurrences of the organism. Mobiluncus spp. occurred only in the vaginas of women with bacterial vaginosis (97%). The organisms were only infrequently recovered from genital samples from 135 males. Organisms were recovered from the urethras and/or coronal sulci of 10 of 44 male consorts of women with bacterial vaginosis. However, after 2 weeks of condom use during sexual intercourse, only M. hominis remained in the urethra of one man. These findings suggest that the organisms associated with bacterial vaginosis are not spread sexually but colonize the vagina from an endogenous intestinal tract site. The pathophysiological mechanisms leading to bacterial vaginosis in a subpopulation of all women are still unknown.
Pharmacokinetics and distribution of a fluoresceinated glycosaminoglycan, sulodexide, in rats. Part II: Organ distribution in rats. (1985)

Fluorescein-labelled sulodexide tissue distribution was studied in the rat after intravenous administration at the dosage of 15 mg/kg. A globular fluorescence was observed mainly in the extracellular matrix and a diffuse one was present in liver and kidney parenchyma lasting for a long time, up to 4 h after administration. In particular in the kidney cortex the fluorescent material was present at the higher time intervals. Fluorescence was also observed in the spleen and in the perivascular areas and in the media of the aortic wall.
Neurosteroid Analogues. 16. A New Explanation for the Lack of Anesthetic Effects of Δ<sup>16</sup>-Alphaxalone and Identification of a Δ<sup>17(20)</sup> Analogue with Potent Anesthetic Activity (2011)

This study addresses the hypothesis that the lack of anesthetic activity for (3α,5α)-3-hydroxypregn-16-ene-11,20-dione (Δ(16)-alphaxalone) is explained by the steroid Δ(16) double bond constraining the steroid 20-carbonyl group to a position that prevents it from favorably interacting with γ-aminobutyric acid type A (GABA(A)) receptors. A series of Δ(16) and Δ(17(20)) analogues of Δ(16)-alphaxalone was prepared to evaluate this hypothesis in binding, electrophysiological, and tadpole anesthesia experiments. The results obtained failed to support the hypothesis. Instead, the results indicate that it is the presence of the C-21 methyl group in Δ(16)-alphaxalone, not the location of the constrained C-20 carbonyl group, that prevents Δ(16)-alphaxalone from interacting strongly with the GABA(A) receptor and having anesthetic activity. Consistent with this conclusion, a Δ(17(20)) analogue of Δ(16)-alphaxalone without a C-21 methyl group was found to be very similar to the anesthetic steroid (3α,5α)-3-hydroxypregnane-11,20-dione (alphaxalone) with regard to time of onset and rate of recovery from anesthesia when administered to mice by tail vein injection.
TRIM proteins regulate autophagy: TRIM5 is a selective autophagy receptor mediating HIV-1 restriction (2014)

The tripartite motif protein family (TRIM) constitutes a class of immune-regulated proteins with antiviral, immune, cancer, and other properties reminiscent of those ascribed to autophagy. We show that TRIMs have dual roles in autophagy: as regulators and as cargo receptors. As regulators, TRIMs nucleate the core autophagy machinery by acting as platforms that assemble ULK1 and BECN1 into a functional complex in preparation for autophagy. TRIMs also act as novel selective autophagy receptors as exemplified by TRIM5/TRIM5α, a known HIV-1 restriction factor with a hitherto poorly defined mode of action. TRIM5 recognizes and targets HIV-1 for autophagic destruction. TRIM5 interactions with mammalian Atg8 proteins are required for this effector function. This establishes TRIM family members as regulators of autophagy, explains the antiretroviral mechanism of TRIM5, and defines a new basis for selective autophagy.
Speculative sequential consistency with little custom storage (2002)

This paper proposes SC++lite, a sequentially consistent system that relaxes memory order speculatively to bridge the performance gap among memory consistency models. Prior proposals to speculatively relax memory order require large custom on-chip storage to maintain a history of speculative processor and memory state while memory order is relaxed. SC++lite uses the memory hierarchy to store the speculative history, providing a scalable path for speculative SC systems across a wide range of applications and system latencies. We use cycle-accurate simulation of shared-memory multiprocessors to show that SC++lite can fully relax memory order while virtually obviating the need for custom on-chip storage. Moreover while demand for storage increases significantly with larger memory latencies, SC++lite's ability to relax memory order remains insensitive to memory latency. An SC++lite system can improve performance over a base SC system by 28% with only 2 KB of custom storage in a system with 16 processors. In contrast, speculative SC systems with custom storage require 51 KB of storage to improve performance by 31% over a base SC system.
The Formation and Subsequent Rearrangement of 7-Chloro-5-phenyl-3,1,4-benzoxadiazepin-2(1H)-one (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Formation and Subsequent Rearrangement of 7-Chloro-5-phenyl-3,1,4-benzoxadiazepin-2(1H)-oneTheodore S. Sulkowski and Scott J. ChildressCite this: J. Org. Chem. 1962, 27, 12, 4424–4426Publication Date (Print):December 1, 1962Publication History Published online1 May 2002Published inissue 1 December 1962https://pubs.acs.org/doi/10.1021/jo01059a072https://doi.org/10.1021/jo01059a072research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
HLA-based simulation environment for distributed SystemC simulation (2011)

We present a new approach of interconnecting diverse SystemC simulations using the High Level Architecture (HLA) as simulation backbone. The presented simulation environment is characterized by its generality and extendability. It basically allows different kinds of execution like distributed simulation of a single SystemC model as well as co-simulation with other arbitrary simulators. The emphasis within this work is on the synchronization and time flow mechanisms that need to be applied when executing a single SystemC model in parallel. A case study is performed by means of a loosely-timed SystemC transaction level model of a homogenous Multi-Processor System-on-Chip. The Sys-temC model exploits temporal decoupling which allows adjusting different computation to synchronization ratios, serving as basis for performance evaluation.
ESTIMATING<i>F</i>-STATISTICS FOR THE ANALYSIS OF POPULATION STRUCTURE (1984)

Corresponding Editor: J. Felsenstein
Metal-catalyzed oxidation of human serum albumin: conformational and functional changes. Implications in protein aging. (1991)

Mild oxidative stress, as elicited by ascorbate, oxygen, and trace metals, affects the binding properties of human serum albumin via purely conformational changes. In fact, no gross alteration can be observed in the electrophoretic and chromatographic patterns of albumin, whereas localized modifications are indicated by the changes in absorption and fluorescence spectra and in polarization degree. The oxidized protein presents a small increase of bityrosine production and a time-dependent increase in the content of carbonyl groups, whereas proteolytic susceptibility is unchanged. A higher affinity for cis-parinaric acid and a slight loss of solubility in high salt indicate a greater surface hydrophobicity. Pinpoint denaturation of the albumin molecule is also suggested by a decreased "esterase" activity in the presence of p-nitrophenyl acetate. Conformational stability evaluated through thermal shock and addition of moderate amounts of guanidine indicate that the oxidized protein is more heat-resistant, less flexible, and more rigid than the native one. Although limited, structural damages afforded by the oxidative stress cause alterations of albumin binding properties as documented by experiments with probes and physiological ligands. The loss of biological activity of human serum albumin induced by ascorbate system appears of medical relevance, because it can affect drug metabolism and particularly drug tolerance in the elderly.
Circuits and technology for Digital's StrongARM and ALPHA microprocessors [CMOS technology] (2002)

Since the introduction of the first ALPHA microprocessor in 1992, Digital has maintained leadership in absolute CPU performance. During the past year, Digital's StrongARM processor has also achieved a leadership position as the fastest CPU capable of operating from a single AA battery cell. Some of the key techniques used to achieve this performance are described in this invited paper.
Chemical vapor deposition growth of carbon nanotubes on Si substrates using Fe catalyst: What happens at the nanotube∕Fe∕Si interface (2006)

Direct growth of carbon nanotubes (CNTs) on silicon is of great importance for their potential exploitation in the semiconductor industry. In this article we investigate the chemical vapor deposition growth of CNTs on Si substrates from ethylene precursor using an iron catalyst. We observe that CNTs are produced only at temperatures between 830 and 980°C, and within this narrow temperature window CNT yield initially increases with temperature to reach a maximum around 900°C and then declines. While the requirement of a minimum temperature to initiate CNT growth can be understood by considering the minimum energy necessary to activate the catalyst particles, characterization of the as-grown CNTs by atomic force microscopy and x-ray photoelectron spectroscopy reveals that a loss of catalyst is responsible for the observed decline in CNT yield above 900°C. However, unlike some previous reports suggesting surface silicide formation as the mechanism for catalyst loss, we find that either subsurface diffusion or evaporation is the mechanism for the loss of catalyst material in the current study.
[A study of polymorphism in UDP-glucuronosyltransferase 1 (UGT-1A1) promoter gene in Korean patients with Gilbert's syndrome]. (2002)

Although the prevalence of A(TA)TAA mutation in Korean patients with Gilbert's syndrome is significantly higher than in the controls, the mutations of the promoter region of UGT-1A1 gene appear not to be the main or sole cause in Gilbert's syndrome in Korea since the prevalence of A(TA)TAA mutation is not so high. Further studies to determine the relationship between other UGT-1A1 gene mutation and Gilbert's syndrome in Korea are needed.
Stereoselective production of (+)-trans-chrysanthemic acid by a microbial esterase: cloning, nucleotide sequence, and overexpression of the esterase gene of Arthrobacter globiformis in Escherichia coli (1995)

The gene coding for a novel esterase which stereoselectively hydrolyzes the (+)-trans (1R,3R) stereoisomer of ethyl chrysanthemate was cloned from Arthrobacter globiformis SC-6-98-28 and overexpressed in Escherichia coli. The cellular content of the active enzyme reached 33% of the total soluble protein in the recombinant E. coli JM105 cells and 5.6 g/liter of culture by high-density cell cultivation. The hydrolytic activity of the recombinant E. coli cells for ethyl chrysanthemate reached 605 mumol of chrysanthemic acid per min per g of dry cells, which is approximately 2,500-fold higher than that of A. globiformis cells. The stereoselective hydrolysis by the recombinant E. coli cells was efficient at substrate concentrations of up to 40% by removing the produced chrysanthemic acid by ultrafiltration. The (+)-trans-chrysanthemic acid produced had 100% optical purity. The amino acid sequence of the esterase was found to be similar to that of several class C beta-lactamases, D,D-carboxypeptidase, D-aminopeptidase, 6-aminohexanoate-dimer hydrolase, and Pseudomonas esterase. The sequence comparison also suggested that the Ser-X-X-Lys motif in the esterase was at the active site of the enzyme.