gebhart/patrepeval huggingface dataset:
Guaranteeing bandwidth and minimizing delay in packet-switched (ATM) networks (2002)

Future high-speed networks that will support integrated video, voice and data applications are expected to utilize the concepts of ATM fast packet switching. The concepts of isolating misbehaving users and sharing resources to achieve optimal delay performance are extremely important to consider when designing queue service policies for practical implementations. Most previous service policies have been designed to satisfy one, but not both, of these goals. We present a novel service policy that combines the desirable features of isolation and sharing to provide guaranteed bandwidth for real-time traffic while attempting to minimize system delay. This service policy, guaranteed-bandwidth minimum-delay (GBMD), operates in two phases. The first phase of the policy ensures that the requested guaranteed bandwidth is delivered to each flow. The second phase, which only occurs when excess bandwidth is available, optimizes given performance criteria (e.g., system delay) by appropriately serving packets. The GBMD policy is easy to implement and flexible to tune based on system requirements. Simulation results show that overall system performance is superior to several other service policies.
Recognition of T cell epitopes and lymphokine secretion by rye grass allergen <i>Lolium perenne</i> I-specific human T cell clones. (1994)

T cell lines (TCL) and CD4+ T cell clones (TCC) with specificity for the rye grass allergen Lolium perenne (Lol p) I were isolated from the blood of nine donors, six having active atopic disease, two being in remission, and one having IgE anti-Lol pI Abs but not atopic disease. The T cell epitopes of Lol pI were determined by TCLs and TCCs reactivity with 23 overlapping, 20 amino acid-long peptides spanning the entire length of the 230 amino acid-long allergen. In addition, the Th subsets (Th1, Th2, Th0, Thp) were determined by measuring IL-2, IFN-gamma, and IL-4 in the supernatants of TCC activated with Lol pI and irradiated APC. TCC from individuals from which a large panel of clones were obtained from 10(5) PBMC initial cultures recognized multiple peptides (5-9) and 23 overlapping peptides a total of 16 were recognized by at least one TCC from one of the patients. These 16 peptides were derived from all areas of the Lol pI molecule, indicating the ability of human Th cells to recognize many peptide epitopes on Lol pI. Although no clear cut immunodominant peptides were detected, T cell clones of 50% of the patients reacted with peptide 191-210. There was no correlation between peptide epitope reactivity and lymphokine secretion pattern of the TCC. Of 12 TCC obtained from six patients with active atopic disease, four (33%) were of Th1, five (42%) of Th2, one (8%) of Thp, and two (17%) of Th0 type. Of 14 TCCs isolated from three atopic donors in remission, five (36%) were of Th1, three (21%) of Th2, four (29%) of Thp, and two (14%) of Th0 type. The data demonstrate that T cells from rye grass pollen allergic patients can recognize multiple peptide epitopes on Lol pI scattered over the entire molecule. No correlation existed between epitope reactivity and lymphokine secretion pattern of the TCC.
Multi-Scale Quantum Transport Modeling of Light Emitting Diodes (2017)

GaN/InGaN multi-quantum-well (MQW) structure is the centerpiece of most mid to-high power light-emitting diodes (LED). The operation of MQW LEDs is determined by the carrier ?ow through complex, extended quantum states, the optical recombination between these states and the optical ?elds in the device. Most existing LED modeling tools are based on semiclassical physics with limited capabilities of modeling quantum phenomenon. Non-equilibrium Green Function Formalism (NEGF) is the state-of-the-art approach for quantum transport, however when it is applied in its textbook form it is numerically too demanding to handle realistically extended devices. This work introduces a new approach to LED modeling based on a multi-scaled NEGF approach that subdivides the critical device domains and separates the quantum transport from the recombination treatments. Several key modeling challenges and their solutions are addressed in this work. The model is applied to a commercial blue LED, and comparison between modeling and experimental results shows good promise.
Metal ion scavenging from water with fine mesh ion exchangers and microporous membranes (1989)

Abstract The productivity of ion exchange processes is usually limited by the diffusional process. The use of very fine mesh resins (down to 10–25 microns diameter) in very thin (ca 3–9 mm) beds supported on a microfiltration membrane of three micron pore diameter is described. These systems were used to process a simulated wastewater containing 4000 ppm of NaCl, plus some calcium and magnesium chlorides, as well as 0.2 ppm each of the metal ions Cu, Ni, Pb, Zn, and Cr (III). Regeneration with dilute HCl produced a concentrate of 1/1000 the volume of the feedwater treated.
ChemInform Abstract: Glycosyl Phosphoramidimidates as Versatile Glycosyl Donors. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein. (1992)

A novel serum amyloid A protein (SAA) has been identified as a normal apolipoprotein component of non-acute phase high density lipoprotein. This novel SAA has been designated "constitutive" SAA (C-SAA) to distinguish it from "acute phase" SAA (A-SAA). C-SAA was partially sequenced, and immunochemical analyses indicated that it constitutes a distinct subclass of apolipoproteins within the SAA superfamily. A C-SAA cDNA clone was isolated from a human liver library and sequenced. The clone predicts a pre-C-SAA molecule of 130 residues from which an 18-residue leader peptide is cleaved. The 112-residue mature molecule is 8 residues longer than human A-SAA; the size difference is due to the presence of an octapeptide between positions 70 and 77 that is not found in the corresponding region of human A-SAA. Paradoxically, octapeptides of similar composition are found at similar positions in the A-SAAs of a number of other species. The C-SAA octapeptide specifies the first two residues of a NSS tripeptide, the only potential N-linked glycosylation site in the molecule. Studies indicate that approximately 50% of these sites are glycosylated, thereby giving rise to two size classes, 14 and 19 kDa, of C-SAA in vivo. Human acute phase liver contains little C-SAA mRNA relative to the levels of A-SAA mRNA, and the treatment of PLC/PRF/5 hepatoma cells with monocyte-conditioned medium does not induce C-SAA mRNA concentrations to detectable levels, in contrast to the massive induction of A-SAA mRNA observed. C-SAA is therefore not a major acute phase reactant.
Induction of Cytolysis of Cultured Lymphoma Cells by Adenosine 3′:5′-Cyclic Monophosphate and the Isolation of Resistant Variants (1973)

Cultured mouse lymphosarcoma cells are killed on exposure to 0.1 mM N(6),O(2')-dibutyryl-adenosine 3':5'-cyclic monophosphate. A population of cells resistant to the killing effect of dibutyryl cyclic AMP at concentrations as high as 1 mM was selected. The growth characteristics of the resistant cells were similar to those of the sensitive parental line. However, the resistant cells contain less cytoplasmic cyclic AMP-binding proteins and decreased cyclic AMP-stimulated protein kinase activity. It is proposed that transition from sensitivity to resistance to dibutyryl cyclic AMP in lymphoma cells is connected with a modification of the cyclic AMP-binding protein, which appears to be the regulatory subunit of the cyclic AMP-activated protein kinase.
Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities (2010)

Phenotypic heterogeneity has been widely observed in cellular populations. However, the extent to which heterogeneity contains biologically or clinically important information is not well understood. Here, we investigated whether patterns of basal signaling heterogeneity, in untreated cancer cell populations, could distinguish cellular populations with different drug sensitivities. We modeled cellular heterogeneity as a mixture of stereotyped signaling states, identified based on colocalization patterns of activated signaling molecules from microscopy images. We found that patterns of heterogeneity could be used to separate the most sensitive and resistant populations to paclitaxel within a set of H460 lung cancer clones and within the NCI-60 panel of cancer cell lines, but not for a set of less heterogeneous, immortalized noncancer human bronchial epithelial cell (HBEC) clones. Our results suggest that patterns of signaling heterogeneity, characterized as ensembles of a small number of distinct phenotypic states, can reveal functional differences among cellular populations.
Differences in N-glycan structures found on recombinant IgA1 and IgA2 produced in murine myeloma and CHO cell lines (2010)

The development and production of recombinant monoclonal antibodies is well established. Although most of these are IgGs, there is also great interest in producing recombinant IgAs since this isotype plays a critical role in providing immunologic protection at mucosal surfaces. The choice of expression system for production of recombinant antibodies is crucial because they are glycoproteins containing at least one N-linked carbohydrate. These glycans have been shown to contribute to the stability, pharmacokinetics and biologic function of antibodies. We have produced recombinant human IgA1 and all three allotypes of IgA2 in murine myeloma and CHO cell lines to systematically characterize and compare the N-linked glycans. Recombinant IgAs produced in murine myelomas differ significantly from IgA found in humans in that they contain the highly immunogenic Galalpha(1,3)Gal epitope and N-glycolylneuraminic acid residues, indicating that murine myeloma is not the optimal expression system for the production of human IgA. In contrast, IgAs produced in CHO cells contained glycans that were more similar to those found on human IgA. Expression of IgA1 and IgA2 in Lec2 and Lec8 cell lines that are defective in glycan processing resulted in a less complex pool of N-glycans. In addition, the level of sialylation of rIgAs produced in murine and CHO cells was significantly lower than that previously reported for serum IgA1. These data underscore the importance of choosing the appropriate cell line for the production of glycoproteins with therapeutic potential.
Antibody-Conjugated Drug Assay for Protease-Cleavable Antibody–Drug Conjugates (2015)

The assay was used to assess the difference in ex vivo drug-linker stability of native-cysteine versus engineered cysteine ADCs and to determine the number of drugs per antibody of a native-cysteine ADC in vivo.
Oxidation of natural targets by dioxiranes. Oxyfunctionalization of steroids (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of natural targets by dioxiranes. Oxyfunctionalization of steroidsPaolo Bovicelli, Paolo Lupattelli, Enrico Mincione, Teresa Prencipe, and Ruggero CurciCite this: J. Org. Chem. 1992, 57, 7, 2182–2184Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/jo00033a053https://doi.org/10.1021/jo00033a053research-articleACS PublicationsRequest reuse permissionsArticle Views1033Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Scalable distributed architecture of the terabit router (2004)

Aggressive research on terabit per second networks has led to dramatic improvements in network transmission speeds. One result of these improvements has been to put pressure on router technology to keep pace. There is more urgent need to research and study terabit (10/sup 12/ bit) router. Traditional routes using shared-bus and central processing unit cannot do it. So how to support the terabit per second data speed is a great challenge for traditional router architecture. In this article, the recent years' new achievements in terabit routers are summarized, the new functions of terabit routers are introduced, and the distributed architecture of new generation super high speed terabit router are analyzed, which put emphasis on the multi-dimensional switching architecture. At last, The prospect of terabit router plays the final role for the paper.
Large Pore Mesostructured Organosilica-Phosphonate Hybrids as Highly Efficient and Regenerable Sorbents for Uranium Sequestration (2012)

Potential consequences of radiological/nuclear events on the population and the environment have led the scientific community to rethink its approach toward a monitoring based on radiochemical separation. In this context, there is a great need to design radioanalytical systems for quickly evaluating environmental impacts in case of incidents and nuclear events. Phosphonate-functionalized large pore three-dimensional (3-D) cubic (KIT-6) and two-dimensional (2-D) hexagonal (SBA-15) silicas have been studied as highly efficient uranium extracting adsorbents in acidic media. In both cases, functionalization was performed by grafting (2-diethylphosphatoethyl) triethoxysilane (DPTS) on the mesopore surface of the silica supports. Particular attention was given to comparison of different pore sizes and pore structures and impact on radionuclide extraction, principally through uranium adsorption isotherms and sorption kinetics studies. All hybrid materials demonstrated very fast adsorption kinetics, reaching equilibrium in less than 60 s. Calculated parameters from the Langmuir model revealed a clearly superior performance of the 3-D cubic KIT-6-based sorbents compared to other equivalents, especially for uranium equilibrium concentrations below 50 mg L–1. Furthermore, a superior maximum adsorption capacity in the range of 54–56 mg of U per gram of sorbent was observed for which it represents almost a 3-fold increase compared to the capacity of commercially available products. High extraction efficiency is demonstrated through dynamic extraction experiments using less than 25 mg of functionalized mesoporous resin analogue. Importantly, the possibility of reusing regenerated mesoporous sorbents is established over several cycles with no loss in uranium extraction capacity suggesting adequate chemical and structural stability of the new sorbent materials.
Update on Hsp90 Inhibitors in Clinical Trial (2009)

Twenty-five years ago the first small molecule inhibitors of Hsp90 were identified. In the intervening years there has been dramatic progress in basic scientific understanding of the Hsp90 chaperone machinery and in the role of Hsp90 in malignancy. The first-in-class Hsp90 inhibitor 17-AAG entered into Phase I clinical trials in 1999. There are now 13 Hsp90 inhibitors in clinical trial, representing multiple drug classes, and hundreds of patients have been treated in adult oncology and pediatric oncology trials. This review will provide an overview of the clinical trial results thus far. In addition, pivotal issues in further development of Hsp90 inhibitors as anticancer drugs will be discussed.
Radioligand Binding Studies of Adrenergic Receptors: New Insights into Molecular and Physiological Regulation (1980)

The advent of direct radioligand binding studies has altered the entire complexion of the experimental approach to the study of adrenergic recep­ tors. The first successful direct binding studies of ,8-adrenergic receptors were reported in 1974 (1-3) and those of a.-adrenergic receptors only in 1976 (4-6). Nonetheless, the application of these methods over the past several years has led to rapid progress in a number of areas. In this article we review some of the highlights of this progress. It has not been our goal to be encyclopedic or all-encompassing. Rather, we have deliberately se­ lected several areas for more extensive coverage. These choices have been, obviously, subjective ones. In general we have focused on studies that provide new insights into factors that appear to regulate the function of the adrenergic receptors, either at a physiological or biochemical level. Only material related to a.and ,8-adrenergic receptors published through the end of 1978 has been systematically considered. Several radioligand antagonists have bee n widely used to study the ,8adrenergic receptors in a variety of tissue systems. These are (-) PH]
Reliability metrics for IGBT power modules (2010)

In the field of IGBT modules, there is currently a plethora of new packaging materials being developed with a view to increased “reliability”. Whilst this approach is often essential to meet the needs for the ever increased demand in harsher environments, the result can often be seen as an over-engineered solution with resultant excessive cost. This paper will present a case study addressing how process control techniques of the substrate solder can demonstrate a significant improvement in the reliability of the product.
MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart (2012)

MicroRNAs (miRs) are small non- coding RNA molecules controlling a plethora of biological processes such as development, cellular survival and senescence. We here determined miRs differentially regulated during cardiac postnatal development and aging. Cardiac function, morphology and miR expression profiles were determined in neonatal, 4 weeks, 6 months and 19 months old normotensive male healthy C57/Bl6N mice. MiR-22 was most prominently upregulated during cardiac aging. Cardiac expression of its bioinformatically predicted target mimecan (osteoglycin, OGN) was gradually decreased with advanced age. Luciferase reporter assays validated mimecan as a bona fide miR-22 target. Both, miR-22 and its target mimecan were co- expressed in cardiac fibroblasts and smooth muscle cells. Functionally, miR-22 overexpression induced cellular senescence and promoted migratory activity of cardiac fibroblasts. Small interference RNA-mediated silencing of mimecan in cardiac fibroblasts mimicked the miR-22-mediated effects. Rescue experiments revealed that the effects of miR-22 on cardiac fibroblasts were only partially mediated by mimecan. In conclusion, miR-22 upregulation in the aging heart contributed at least partly to accelerated cardiac fibroblast senescence and increased migratory activity. Our results suggest an involvement of miR-22 in age-associated cardiac changes, such as cardiac fibrosis.
Fluorescent Pseudomonas Strains with only Few Plant-Beneficial Properties Are Favored in the Maize Rhizosphere (2016)

Plant Growth-Promoting Rhizobacteria (PGPR) enhance plant health and growth using a variety of traits. Effective PGPR strains typically exhibit multiple plant-beneficial properties, but whether they are better adapted to the rhizosphere than PGPR strains with fewer plant-beneficial properties is unknown. Here, we tested the hypothesis that strains with higher numbers of plant-beneficial properties would be preferentially selected by plant roots. To this end, the co-occurrence of 18 properties involved in enhanced plant nutrition, plant hormone modulation, or pathogen inhibition was analyzed by molecular and biochemical methods in a collection of maize rhizosphere and bulk soil isolates of fluorescent Pseudomonas. Twelve plant-beneficial properties were found among the 698 isolates. Contrarily to expectation, maize preferentially selected pseudomonads with low numbers of plant-beneficial properties (up to five). This selection was not due to the predominance of strains with specific assortments of these properties, or with specific taxonomic status. Therefore, the occurrence of only few plant-beneficial properties appeared favorable for root colonization by pseudomonads.
Knowledge-based design support system for computer communication system (1988)

A knowledge-based design methodology for computer communication systems is proposed, along with a framework for a knowledge-based design support system. The design methodology is based on the user-requirements-oriented approach parameters. According to these requirements, formal specifications are defined as user's view virtual machine (UVM) and designer's view virtual machine (DVM). These virtual machines are constructed as knowledge models from the specifications. Due to the design methodology, a knowledge-based design support system for computer communication systems, called KDSS, is constructed. This design support system consists of many expert systems corresponding to the design phases given by methodology. A design example is given to illustrate the methodology.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Extended variances and autoregressive/moving average algorithm for the measurement and synthesis of oscillator phase noise (2003)

Two related aspects are discussed of the recent research work carried out at Portsmouth Polytechnic in the UK regarding numerical and digital techniques for the measurement and synthesis of phase noise in oscillators. The first aspect concerns the introduction of a statistical quantity termed extended Hadamard variance to be applied in frequency stability analysis by making use of digital frequency counter measurements. The properties, the potential interest and the usefulness of this parameter are briefly demonstrated and applied to the study of a signal from a synthesizer that is frequency-modulated by white noise followed by the frequency counter and signal processing. It is shown that not only the Hadamard variance but also the Allan variance and the extended two-sample variance are sets of this variance. The second aspect refers to modern requirements for numerical simulation of random noise, emulating phase or frequency fluctuations. The authors describe the autoregressive integrated moving average technique used to generate various types of random noise, including radio propagation FM noise, and the Monte Carlo approach to transform from one distribution to another.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Polynuclear hydrocarbons in tobacco and tobacco smoke. Part II. The origin of 3:4-benzopyrene found in tobacco and tobacco smoke (1960)

H. R. Bentley and J. G. Burgan, Analyst, 1960, 85, 723 DOI: 10.1039/AN9608500723
Position sensing and control of a linear synchronous motor (1995)

Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.