gebhart/patrepeval huggingface dataset:
Temperature-Dependent Characteristics of the Inverted Delta-Doped V-Shaped InGaP/In<sub>x</sub>Ga<sub>1-x</sub>As/GaAs Pseudomorphic Transistors (1999)

The temperature-dependent characteristics of InGaP/In x Ga 1- x As/GaAs pseudomorphic transistors with an inverted delta-doped V-shaped channel have been studied. Due to the presented wide-gap InGaP Schottky layer and the V-shaped channel structure, the degradation of device performance with increasing the temperature is not so significant. Experimentally, for a 1×100 µm 2 device, the gate-drain voltages at a gate leakage current of 260 µA/mm and the maximum transconductances g m,max are 30 (22.2) V and 201 (169) mS/mm at the temperature of 300 K (450 K), respectively. Meanwhile, the broad and flat drain current operation regimes for high g m , f T , and f max are obtained.
CD4+CD25+ Regulatory T Cell Depletion Modulates Anxiety and Depression-Like Behaviors in Mice (2012)

Stress has been shown to suppress immune function and increase susceptibility to inflammatory disease and psychiatric disease. CD4(+)CD25(+) regulatory T (Treg) cells are prominent in immune regulation. This study was conducted to determine if anti-CD25 antibody (Ab) mediated depletion of Treg cells in mice susceptibility to stress-induced development of depression-like behaviors, as well as immunological and neurochemical activity. To accomplish this, an elevated plus-maze test (EPM), tail suspension test (TST), and forced swim test (FST) were used to examine depression-like behaviors upon chronic immobilization stress. Immune imbalance status was observed based on analysis of serum cytokines using a mouse cytometric bead array in conjunction with flow cytometry and changes in the levels of serotonin (5-HT) and dopamine (DA) in the brain were measured by high performance liquid chromatography (HPLC). The time spent in the open arms of the EPM decreased significantly and the immobility time in the FST increased significantly in the anti-CD25 Ab-treated group when compared with the non stressed wild-type group. In addition, interlukin-6 (IL-6), tumor necrosis factor-á (TNF-á), interlukin-2 (IL-2), interferon-gamma (IFN-γ), interlukin-4 (IL-4) and interlukin-17A (IL-17A) concentrations were significantly upregulated in the stressed anti-CD25 Ab-treated group when compared with the non stressed wild-type group. Furthermore, the non stressed anti-CD25 Ab-treated group displayed decreased 5-HT levels within the hippocampus when compared with the non stressed wild-type group. These results suggest that CD4(+)CD25(+) Treg cell depletion modulated alterations in depressive behavior, cytokine and monoaminergic activity. Therefore, controlling CD4(+)CD25(+) Treg cell function during stress may be a potent therapeutic strategy for the treatment of depression-like symptoms.
Development of a Knowledge-Based Model Management System (1988)

This paper presents a software architecture and a graph-based framework for developing knowledge-based model management systems. The architecture consists of three major components: a model utilization subsystem, a modeling subsystem, and an inference engine. The core of the system is the inference engine that applies the graph-based framework to drive the processes of model integration and selection. The graph-based framework includes a model representation scheme and reasoning mechanisms. The representation scheme depicts a set of data as a node, a set of functions as an edge, and a basic model as a combination of two nodes and one connecting edge. Based on this scheme, mechanisms for model integration and selection are discussed. These mechanisms enable a model management system to create composite models automatically. A prototype implemented in PROLOG is also presented to demonstrate the graph-based framework.
Evaluation and Comparison of Test Methods to Measure the Oxidation Stability of Neat Biodiesel (2005)

The purpose of this project was to compare and evaluate several candidate test methods for evaluating oxidation stability of biodiesel.
Efficient lawful interception in mobile IPv6 networks (2006)

The Lawful Interception (LI) of communications is necessary in modern telecommunications networks in order to help law enforcement agencies with the investigation and prosecution of criminal activities. For IP networks that support user mobility, such as Mobile IP, the LI solution must be distributed throughout the network in order to satisfy the requirement that it capture 100% of a target user’s communications. This distribution is in conflict with another requirement which requires that the identity of the interception target remain unknown outside of the LI system: increasing the distribution of the LI solution to more nodes, as well as being inefficient, means that the identity of the target of the interception is more susceptible to being known via attacks, social engineering or unintentional misconfiguration. In this paper, we analyse LI solutions for Mobile IPv6 networks in terms their efficiency. We define an efficiency ratio which measures the balance between the requirement to capture 100% of target traffic and how distributed the efforts to intercept are. We examine the effect of alternative LI solutions on this measure through simulation. Our results show that a client driven approach which incorporates appropriate caching mechanisms provides a significant improvement in efficiency when compared to a traditional client/server approach.
Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance (2008)

Imatinib mesylate is a potent, molecularly targeted therapy against the oncogenic tyrosine kinase BCR-ABL. Although imatinib mesylate has considerable efficacy against chronic myeloid leukemia (CML), advanced-stage CML patients frequently become refractory to this agent. The bone marrow is the predominant microenvironment of CML and is a rich source of both soluble factors and extracellular matrices, which may influence drug response. To address the influence of the bone marrow microenvironment on imatinib mesylate sensitivity, we used an in vitro bone marrow stroma model. Our data show culturing K562 cells, in bone marrow stroma-derived conditioned medium (CM), is sufficient to cause resistance to BCR-ABL inhibitors. Drug resistance correlated with increased pTyrStat3, whereas no increases in pTyrStat5 was noted. Moreover, resistance was associated with increased levels of the Stat3 target genes Bcl-xl, Mcl-1, and survivin. Finally, reducing Stat3 levels with small interfering RNA sensitized K562 cells cultured in CM to imatinib mesylate-induced cell death. Importantly, Stat3 dependency was specific for cells grown in CM, as reducing Stat3 levels in regular growth conditions had no effect on imatinib mesylate sensitivity. Together, these data support a novel mechanism of BCR-ABL-independent imatinib mesylate resistance and provides preclinical rationale for using Stat3-inhibitors to increase the efficacy of imatinib mesylate within the context of the bone marrow microenvironment.
Preparation of Enamino Dinitriles and Pyridines by Reduction of Geminal Dinitriles with LiAIH<sub>4</sub> (1969)

Abstract For corrigendum see DOI: 10.1002/anie.196906171
The Carnegie Curve (2012)

Abstract The Earth’s fair weather atmospheric electric field shows, in clean air, an average daily variation which follows universal time, globally independent of the measurement position. This single diurnal cycle variation (maximum around 19UT and minimum around 03UT) is widely known as the Carnegie curve, after the geophysical survey vessel of the Carnegie Institution of Washington on which the original measurement campaigns demonstrating the universal time variation were undertaken. The Carnegie curve’s enduring importance is in providing a reference variation against which atmospheric electricity measurements are still compared; it is believed to originate from regular daily variations in atmospheric electrification associated with the different global disturbed weather regions. Details of the instrumentation, measurement principles and data obtained on the Carnegie’s seventh and final cruise are reviewed here, also deriving new harmonic coefficients allowing calculation of the Carnegie curve for different seasons. The additional harmonic analysis now identifies changes in the phasing of the maximum and minimum in the Carnegie curve, which shows a systematic seasonal variation, linked to the solstices and equinoxes, respectively.
Grain-size distribution in ion-irradiated amorphous Si films on glass substrates (1992)

Amorphous Si films containing crystal seeds can be converted to a polycrystal by an ion beam with heating at 350 °C on silica glass substrates, and the density of the crystal grain is almost the same as that of the initial seed. However, the size and density of the crystal seed decrease when the ion irradiation is performed without external heating. The average grain size in the completely crystallized film can be controlled by decreasing the crystal seed density before crystallization. The growth process of crystal grains (average grain diameter R and standard deviation σR) is reported and the gradient ΔσR/ΔR is estimated to be about 0.15. A model calculation is performed to estimate the gradient on the assumption that the growth rate is governed by the plane (111) crystallization and the calculated value is 0.05.
Frequency and interference diversity in slow frequency hopping multiple access systems (2002)

An analytical approach is proposed to evaluate the performance of a slow frequency hopping (SFH) mobile radio system. The effects of frequency diversity and interference diversity are investigated by considering the use of error correcting codes, multipath Rayleigh fading and cochannel interference; by means of an analytical procedure and proper definition of carrier-to-interference ratio the role of several parameters such as the number of hopping frequencies and system load are emphasized.
Gasflooding Experiments for the East Side of the Yates Field Unit (1990)

Summary In a series of immiscible gasflood experiments at current conditions for the east side of the Yates Field Unit (450 psi, 82°F [3.10 MPa, 301 K]), the oil recovery efficiency of CO2 was compared with that of gas-cap gas (GCG). Flooding rates in vertically mounted, preserved-state cores were near the critical velocities for gravity-stable displacement. Oil recoveries with CO2 were 6 to 11 % of original oil in place (OOIP) greater than those of GCG. Flooding results were interpreted with a modified Buckley-Leverett end-effect simulator. With this simulator, the gas/oil saturation profile that results from capillary end effects could be modeled. The modeling study showed that incremental oil recovery with CO2 resulted from oil swelling, oil-viscosity reduction, and gas/oil interfacial-tension (IFT) reduction.
Regulation of Enzymes of Urea and Arginine Synthesis (1992)

The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved ...Read More
Further evaluation of luminol-enhanced luminescence in the diagnosis of disorders of leukocyte oxidative metabolism: role of myeloperoxidase. (1983)

Chemiluminescence can be used to identify defects in the oxidative metabolism of granulocytes. This procedure has recently been adopted for use with microliter quantities of whole blood, appropriate for prenatal or neonatal study. Although the contribution of myeloperoxidase to the chemiluminescence assay has been noted, the possible diagnostic confusion between chronic granulomatous disease of childhood (which is rare and severe) and myeloperoxidase deficiency (which is common and of little clinical consequence) has not been stressed. We report a father and his infant daughter whose cells emitted no light in the luminol-enhanced luminescence assay; both patients are totally peroxidase deficient. These results emphasize the hereditary nature of myeloperoxidase deficiency, and the possibility for erroneous diagnosis of chronic granulomatous disease of childhood based on the luminol-enhanced luminescence test.
Nuclear Receptor Interaction Protein (NRIP) expression assay using human tissue microarray and immunohistochemistry technology confirming nuclear localization (2008)

This is the first study to use a human TMA and IHC to validate the nuclear localization for this newly identified NRIP expression. In considering the use of NRIP as a potential diagnostic tool for human malignancies survey, it is important to note that NRIP expression carries a sensitivity of only 23%, but has a specificity of 100%. There is also a significant difference in positive NRIP expression between primary carcinomatous tissues and matched controlled healthy tissues. Although further large-scale studies will merit to be conducted to evaluate its role as a potential adjunct for cancer diagnosis, data from this study provides valuable references for the future investigation of the biological functions of NRIP in humans.
Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory (2009)

With decreasing local and global connectivity parameters, the large-scale functional brain network organization in AD deviates from the optimal 'small-world' network structure towards a more 'random' type. This is associated with less efficient information exchange between brain areas, supporting the disconnection hypothesis of AD. Surprisingly, FTLD patients show changes in the opposite direction, towards a (perhaps excessively) more 'ordered' network structure, possibly reflecting a different underlying pathophysiological process.
Tyrosine protein kinase substrates in Philadelphia-positive human chronic granulocytic leukemia derived cell lines (K562 and BV173): detection by using an immunoblotting technique. (1987)

In chronic granulocytic leukemia (CGL) the Philadelphia translocation results in the production of a novel 210 kDa bcr-abl fusion protein which shows increased tyrosine protein kinase activity in comparison with its normal 145 kDa c-abl counterpart. Using an immunoblotting method and antiphosphotyrosine antibody, we have identified the tyrosine protein kinase substrates present in intact cells from two Philadelphia-positive CGL derived cell lines (K562 and BV173) and compared these with the substrates present in a Philadelphia-negative myeloid cell line (HL60). We have demonstrated an increased number of substrates, particularly of low (less than 110 kDa) molecular weight in the K562 or BV173 cells compared with the HL60 cells. There is virtual identity of the substrates present in the two CGL-derived lines. This work supports the hypothesis that the functional changes present in the bcr-abl 210 kDa protein of CGL results in altered tyrosine phosphorylation of intracellular proteins and that this is of importance in the pathogenesis of CGL.
Autonomous control of underground mining vehicles using reactive navigation (2002)

This paper describes how many of the navigation techniques developed by the robotics research community over the last decade may be applied to a class of underground mining vehicles (local haul dump (LHD) and haul trucks). We review the current state of the art in this area and conclude that there are essentially two basic methods of navigation applicable. We describe an implementation of a reactive navigation system on a 30 tonne LHD which has achieved full-speed operation at a production mine.
Recent Advances in Transition Metal Catalyzed Oxidation of Organic Substrates with Molecular Oxygen (2005)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRecent Advances in Transition Metal Catalyzed Oxidation of Organic Substrates with Molecular OxygenT. Punniyamurthy, Subbarayan Velusamy, and Javed IqbalView Author Information Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India, and Dr. Reddy's Research Foundation, Miyapur, Hyderabad 500050, India Cite this: Chem. Rev. 2005, 105, 6, 2329–2364Publication Date (Web):May 6, 2005Publication History Received7 January 2005Published online6 May 2005Published inissue 1 June 2005https://pubs.acs.org/doi/10.1021/cr050523vhttps://doi.org/10.1021/cr050523vresearch-articleACS PublicationsCopyright © 2005 American Chemical SocietyRequest reuse permissionsArticle Views22251Altmetric-Citations1585LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysts,Hydrocarbons,Organic reactions,Oxidation,Oxygen Get e-Alerts
Fine-grained Contract Negotiation for Hierarchical Software Components (2005)

Component-based development addresses the complexity of large applications by building software systems from reusable software components. To support reuse and successfully combine units of software, the contractual approach turns out to be well-suited to specify and to verify components and their interactions. However, as contracts must support functional and extra-functional aspects, they are frequently challenged by fluctuations in extra-functional properties and dynamic reconfigurations of components. In this paper, we propose a negotiation model in which components have clearly identified roles and interact in order to automatically restore the validity of contracts. The negotiation model currently supports a concession-based negotiation policy and is well-suited to behavioral contracts based on executable assertions. This model is integrated into ConFract, a contracting system for the fractal hierarchical component model.
Learning Midlevel Image Features for Natural Scene and Texture Classification (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper deals with coding of natural scenes in order to extract semantic information. We present a new scheme to project natural scenes onto a basis in which each dimension encodes statistically independent information. Basis extraction is performed by independent component analysis (ICA) applied to image patches culled from natural scenes. The study of the resulting coding units (coding filters) extracted from well-chosen categories of images shows that they adapt and respond selectively to discriminant features in natural scenes. Given this basis, we define global and local image signatures relying on the maximal activity of filters on the input image. Locally, the construction of the signature takes into account the spatial distribution of the maximal responses within the image. We propose a criterion to reduce the size of the space of representation for faster computation. The proposed approach is tested in the context of texture classification (111 classes), as well as natural scenes classification (11 categories, 2037 images). Using a common protocol, the other commonly used descriptors have at most 47.7% accuracy on average while our method obtains performances of up to 63.8%. We show that this advantage does not depend on the size of the signature and demonstrate the efficiency of the proposed criterion to select ICA filters and reduce the dimension. </para>
Stressed out: the skeletal muscle ryanodine receptor as a target of stress (2008)

Over the past century, understanding the mechanisms underlying muscle fatigue and weakness has been the focus of much investigation. However, the dominant theory in the field, that lactic acidosis causes muscle fatigue, is unlikely to tell the whole story. Recently, dysregulation of sarcoplasmic reticulum (SR) Ca(2+) release has been associated with impaired muscle function induced by a wide range of stressors, from dystrophy to heart failure to muscle fatigue. Here, we address current understandings of the altered regulation of SR Ca(2+) release during chronic stress, focusing on the role of the SR Ca(2+) release channel known as the type 1 ryanodine receptor.
A Novel Instrument and Technique for Using Seprafilm Hyaluronic Acid/Carboxymethylcellulose Membrane During Laparoscopic Myomectomy (2006)

Myomectomy is associated with the development of adhesions, and even when the patient is operated on laparoscopically, postoperative adhesions can often occur. Seprafilm is an effective and highly safe barrier to postoperative adhesions. However, it is vulnerable to tears and difficult to handle. We developed a device to introduce Seprafilm into the abdominal cavity during the laparoscopic procedure. Seprafilm is divided into 6 pieces and the pieces are rolled and inserted into the purpose-built introducer to be guided into the abdominal cavity. The inner syringe is pushed in and Seprafilm is applied onto the uterine wound with two grasping forceps. Of 117 patients in our study, we were able to use Seprafilm on 114 patients (97.4%). In total, 221 pieces of Seprafilm were used, and 87 pieces were damaged during the operation. Of these 87 pieces, 58 were damaged when inserted into the introducer, though this kind of loss tended to decrease with training, and 29 pieces were damaged during application to the wound. Seprafilm can be used safely and efficiently during laparoscopic surgery.
News About Human Milk Banking in Germany (2005)

Germany has a longstanding tradition of donor human milk banking. The first human milk bank was founded in 1919. While human milk banking was widespread during the 1950s, by 1972 it reached its lowest level (52.000 1/year). By the end of the 80's it had climbed to its highest level before reunification of the two parts of Germany: About 200.000 l/year were collected in the 60 milk banks of the eastern part of Germany. The need for donor milk throughout this region was more than adequately met. After the reunification of Germany, a lot of milk banks were closed. Position Statement of the Nutrition Commission of the German Pediatric Society, (July 1991): Donor milk is needed as an important option for the care and treatment of premature and sick newborns and babies. Its use in pediatrics has a primarily preventive and therapeutic character particularly in immature newborns and in cases of serious intestinal illness in infancy such as Necrotizing Enterocolitis (NEC), Morbus Hirschsprung, intractable diarrhea and cow's milk protein intolerance.