gebhart/patrepeval huggingface dataset:
Orientation planning in continuous path applications for wrist partitioned manipulators (1992)

The paper presents an algorithm of trajectory planning for wrist partitioned robotic manipulators. The desired translational trajectory is defined as a continuous function in Cartesian co-ordinates. The desired orientation is defined as a continuous function of the Frenet frame. Therefore, orientation is planned without influence of geometric changes along the translational path. The path is generated as a sequence of elementary motions. Each new position is defined as a function of the previous one. After having derived a position, the orientation is planned using a maximising process. The present algorithm avoids singularities, because there is no need for using the inverse kinematics.
Single Cell Total RNA Sequencing through Isothermal Amplification in Picoliter-Droplet Emulsion (2016)

Prevalent single cell RNA amplification and sequencing chemistries mainly focus on polyadenylated RNAs in eukaryotic cells by using oligo(dT) primers for reverse transcription. We develop a new RNA amplification method, "easier-seq", to reverse transcribe and amplify the total RNAs, both with and without polyadenylate tails, from a single cell for transcriptome sequencing with high efficiency, reproducibility, and accuracy. By distributing the reverse transcribed cDNA molecules into 1.5 × 10<sup>5</sup> aqueous droplets in oil, the cDNAs are isothermally amplified using random primers in each of these 65-pL reactors separately. This new method greatly improves the ease of single-cell RNA sequencing by reducing the experimental steps. Meanwhile, with less chance to induce errors, this method can easily maintain the quality of single-cell sequencing. In addition, this polyadenylate-tail-independent method can be seamlessly applied to prokaryotic cell RNA sequencing.
The Synthesis of Cyclic Alcohols and Olefins by the Interaction of Dimagnesium Halides and Esters (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of Cyclic Alcohols and Olefins by the Interaction of Dimagnesium Halides and EstersCostin D. Nenitzescu and Ileana NecsoiuCite this: J. Am. Chem. Soc. 1950, 72, 8, 3483–3486Publication Date (Print):August 1, 1950Publication History Published online1 May 2002Published inissue 1 August 1950https://pubs.acs.org/doi/10.1021/ja01164a046https://doi.org/10.1021/ja01164a046research-articleACS PublicationsRequest reuse permissionsArticle Views301Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cloning, sequencing, and transcriptional regulation of the Vibrio cholerae fur gene (1992)

Many genes involved in the transport of iron by bacteria as well as in pathogenesis are regulated by the environmental concentration of iron, with increased expression under low-iron conditions. In Escherichia coli, transcriptional regulation by iron depends on the fur gene. A virulence gene in Vibrio cholerae (irgA) is also transcriptionally regulated by iron, and the promoter of irgA contains a dyad repeat homologous to Fur binding sites in E. coli. Southern hybridization of V. cholerae chromosomal DNA, using an internal fragment of E. coli fur as a probe, showed a single hybridizing sequence under conditions of low stringency. We derived a restriction map in the vicinity of this hybridizing sequence; overlapping PstI and HindIII fragments were identified at the center of this map. The cloned PstI fragment failed to complement an E. coli fur mutant; sequence analysis revealed an open reading frame that began just downstream of the PstI site, suggesting that the clone was not functional because it lacked its promoter. The overlapping HindIII fragment contained the intact V. cholerae fur gene with its promoter and complemented an E. coli fur mutant. DNA sequencing of the HindIII fragment demonstrated a single open reading frame of 150 amino acids that was 76% homologous to E. coli Fur. Primer extension analysis localized two promoters for the V. cholerae fur gene; no significant homology to an E. coli Fur binding site was identified for either promoter. Northern blot analysis showed that the two fur transcripts were not strongly regulated by iron. These studies identify a gene in V. cholerae homologous in both function and sequence to the fur gene of E. coli, and we have designated this gene the fur gene of V. cholerae.
Strategy for membrane protein crystallization exemplified with OmpA and OmpX (1999)

The bacterial outer membrane proteins OmpA and OmpX were modified in such a manner that they yielded bulky crystals diffracting X-rays isotropically beyond 2 A resolution and permitting detailed structural analyses. The procedure involved semi-directed mutagenesis, mass production into inclusion bodies, and (re)naturation therefrom; it should be applicable for a broader range of membrane proteins.
Influence of grain size on the transformation temperature of C49 TiSi2 to C54 TiSi2 (1987)

Titanium disilicide exists in two possible crystallographic structures: the C49 (ZrSi2) structure and the C54 structure. At low annealing temperatures (400–650 °C), the C49 TiSi2 phase is formed. It transforms to the C54 phase at annealing temperatures between 650–800 °C. The transformation temperature (Ttr), however, appears to be influenced by the microstructure of the C49 phase. This is concluded from the observed difference in Ttr for TiSi2 thin films with varying average grain sizes.
REVIEWS OF BOOKS (1952)

REVIEWS OF BOOKS Get access The Record Guide. By Edward Sackville-West and Desmond Shawe-Taylor. pp. 763. (London: Collins. 1951. 30s.) W. S. M. W. S. M. Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume XXXIII, Issue 1, January 1952, Pages 83–87, https://doi.org/10.1093/ml/XXXIII.1.83 Published: 01 January 1952
Acetylcholine Detection at Micromolar Concentrations with the Use of an Artificial Receptor-Based Fluorescence Switch (2008)

An inclusion complex between water-soluble p-sulfocalix[n]arene (Cn, n=4, 6, 8) and the chromophore trans-4-[4-(dimethylamino)styryl]-1-methylpyridinium-p-toluenesulfonate (D) formed the basis for a highly sensitive sensor for the selective detection of neurotransmitter acetylcholine (ACh). Formation of the [Cn.D] complex (Ka=approximately 10(5) M(-1)) was accompanied by a drastic increase (up to 20-60-fold) in the chromophore relative quantum yield and by a large hypsochromic shift of the emission band maximum. The observed optical effects are fully reversible: ACh displaces the chromophore molecules from the calixarene cavity as shown by the reappearance of the free chromophore emission band. Formation and dissociation of the complex were studied by fluorescence, 1H NMR, and UV-vis absorption spectroscopies. The [Cn.D] complex is capable of sensing ACh selectively in solution at sub-micromolar concentrations. Immobilization of monocarboxyl p-sulfocalix[4]arene (C4m) on an oxide-containing silicon surface is in keeping with its properties, such as chromophore binding and the ability of the immobilized inclusion complex to detect ACh. The unique [Cn.D] complex optical switching paves the way for application in ACh imaging and optoelectronic sensing.
A new diode clamping multilevel inverter (1999)

This paper proposes a new diode clamping multilevel Inverter, which gets rid of the need for series association of the clamping diodes in the conventional diode clamping multilevel inverter. The new diode clamping inverter utilizes the same number of switches and diodes as the conventional one for synthesizing an inverter of a given level. Operation fundamentals, clamping mechanism as well as experimental verifications are presented.
Optical Studies of Electrical Discharge-Liquid Propellant Interactions. (1986)

In the course of investigating the ignition of liquid propellants by electrically initiated plasma discharges, it became clear that a number of complex and important processes were taking place within the reaction chamber, commonly called a plasma plug. This report describes the development of transparent plugs that permit optical access to the reaction chamber, and optical and electronic systems for high speed cine schlieren, shadow, and direct photography of events taking place within the cavity. A number of observations are presented and briefly discussed that demonstrate the power and versatility of the equipment. Keywords: High Speed Photography; Arc Discharges; Electrolysis; Droplet Formation; Combustion.
Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12 (2002)

IL-12 is considered a critical proinflammatory cytokine for autoimmune diseases such as multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). IL-12 is a heterodimer composed of a p35 subunit and a common p40 subunit shared by other cytokines. Both IL-12 p40(-/-) and p35(-/-) mice fail to produce IL-12 p70 heterodimer. However, in contrast to p40(-/-) mice, p35(-/-) mice are highly susceptible to the induction of EAE, establishing that IL-12 p70 is not essential for the development of EAE. When compared with wild-type mice, both p40(-/-) and p35(-/-) mice show deficiencies in primary IFN-gamma responses by lymph node cells. Expression profiling of the inflamed CNS revealed that Th2 cytokines such as IL-4 and IL-10 are upregulated in p35(-/-) mice, whereas LT-alpha and TNF-alpha levels are reduced. These studies show that a molecule other than IL-12 p70, which uses the p40 subunit, fulfills the functions previously attributed to IL-12 with regard to the development and pathogenesis of this autoimmune disease.
Aneuploidy vs. gene mutation hypothesis of cancer: Recent study claims mutation but is found to support aneuploidy (2000)

For nearly a century, cancer has been blamed on somatic mutation. But it is still unclear whether this mutation is aneuploidy, an abnormal balance of chromosomes, or gene mutation. Despite enormous efforts, the currently popular gene mutation hypothesis has failed to identify cancer-specific mutations with transforming function and cannot explain why cancer occurs only many months to decades after mutation by carcinogens and why solid cancers are aneuploid, although conventional mutation does not depend on karyotype alteration. A recent high-profile publication now claims to have solved these discrepancies with a set of three synthetic mutant genes that "suffices to convert normal human cells into tumorigenic cells." However, we show here that even this study failed to explain why it took more than "60 population doublings" from the introduction of the first of these genes, a derivative of the tumor antigen of simian virus 40 tumor virus, to generate tumor cells, why the tumor cells were clonal although gene transfer was polyclonal, and above all, why the tumor cells were aneuploid. If aneuploidy is assumed to be the somatic mutation that causes cancer, all these results can be explained. The aneuploidy hypothesis predicts the long latent periods and the clonality on the basis of the following two-stage mechanism: stage one, a carcinogen (or mutant gene) generates aneuploidy; stage two, aneuploidy destabilizes the karyotype and thus initiates an autocatalytic karyotype evolution generating preneoplastic and eventually neoplastic karyotypes. Because the odds are very low that an abnormal karyotype will surpass the viability of a normal diploid cell, the evolution of a neoplastic cell species is slow and thus clonal, which is comparable to conventional evolution of new species.
Statistical Inference for Valued-Edge Networks: The Generalized Exponential Random Graph Model (2012)

Across the sciences, the statistical analysis of networks is central to the production of knowledge on relational phenomena. Because of their ability to model the structural generation of networks based on both endogenous and exogenous factors, exponential random graph models are a ubiquitous means of analysis. However, they are limited by an inability to model networks with valued edges. We address this problem by introducing a class of generalized exponential random graph models capable of modeling networks whose edges have continuous values (bounded or unbounded), thus greatly expanding the scope of networks applied researchers can subject to statistical analysis.
Use of Adjuvant Intralesional Bevacizumab for Aggressive Respiratory Papillomatosis in Children (2013)

Intralesional bevacizumab treatment may increase duration of time between surgical procedures and decrease number of procedures per year, while improving voice QOL.
The Optimum Kinematic Design of a Spherical Three-Degree-of-Freedom Parallel Manipulator (1987)

Abstract In this paper, the design of a spherical three-degree-of-freedom parallel manipulator is considered from a kinematic viewpoint. Three different design criteria are established and used to produce designs having optimum characteristics. These criteria are i)symmetry ii)workspace maximization, and iii)isotropy. The associated problems are formulated and their solutions, one of them requiring to resort to a numerical method, are provided. Optimum designs are thereby obtained. A dicussion on singularities is also included.
Network-driven motion estimation for wireless video terminals (1997)

This paper describes a new compression algorithm, termed network-driven motion estimation (NDME), which reduces the power dissipation of wireless video devices in a networked environment by exploiting the predictability of object motion. Since the location of an object in the current frame can often be predicted accurately from its location in previous frames, it is possible to optimally partition the motion estimation computation between the portable devices and high powered compute servers on the wired network. In network-driven motion estimation, a remote high-powered resource at the base-station (or on the wired network), predicts the motion vectors of the current frame from the motion vectors of the previous frames. The base-station sends these predicted motion vectors to a portable video encoder, where motion compensation proceeds as usual. Network-driven motion estimation adaptively adjusts the coding algorithm based on the amount of motion in the sequence, using motion prediction to code portions of the video sequence which contain a large amount of motion and conditional replenishment to code portions of the sequence which contain little scene motion. This algorithm achieves a reduction in the number of operations performed at the encoder for motion estimation by over two orders of magnitude while introducing minimal degradation to the decoded video compared with full search encoder-based motion estimation.
QUASI-STATIC ANALYSIS OF MATERIALS WITH SMALL TUNABLE STACKED SPLIT RING RESONATORS (2005)

This paper presents a quasi-static analysis of a metamaterial consisting of a three-dimensional array of small tunable stacked split ring resonators (SSRRs). The resonance frequency of the proposed resonator structure can be controlled by adjusting the auxiliary lumped elements which are inserted between the split of each ring. In addition, the size of the ring resonator can be reduced to an order of 0.01 that is one tenth that of the split ring resonator (SRR) by choosing the proper lumped elements. The analysis is based on the quasi-static Lorentz theory, and the generalized matrix representation of the macroscopic constitutive relations of the composite medium is calculated.
Efficient Prediction of Network Traffic for Real-Time Applications (2019)

Accurate real-time traffic prediction is required in many networking applications like dynamic resource allocation and power management. This paper explores a number of predictors and searches for a predictor which has high accuracy and low computation complexity and power consumption. Many predictors from three different classes, including classic time series, artificial neural networks, and wavelet transform-based predictors, are compared. These predictors are evaluated using real network traces. Comparison of accuracy and cost, both in terms of computation complexity and power consumption, is presented. It is observed that a double exponential smoothing predictor provides a reasonable tradeoff between performance and cost overhead.
Reactions with α-Substituted β-Propiolactones. I. 4,4-Disubstituted 2-Oxazolidinones: Research on Compounds Active on the Central Nervous System. XXIII<sup>1a</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions with α-Substituted β-Propiolactones. I. 4,4-Disubstituted 2-Oxazolidinones: Research on Compounds Active on the Central Nervous System. XXIII1aBRUNO I. R. NICOLAUS, LUIGI MARIANI, GIANGUALBERTO GALLO, and EMILIO TESTACite this: J. Org. Chem. 1961, 26, 7, 2253–2255Publication Date (Print):July 1, 1961Publication History Published online1 May 2002Published inissue 1 July 1961https://pubs.acs.org/doi/10.1021/jo01351a025https://doi.org/10.1021/jo01351a025research-articleACS PublicationsRequest reuse permissionsArticle Views122Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: supersensitivity to superantigen‐induced septic shock (1996)

Rodents are significantly less sensitive to enterotoxin-induced shock, and are thus not valid human disease models. Here, we describe a mouse strain carrying the human CD4 and human major histocompatibility complex (MHC) class II (DQ6) transgenes in an endogenous CD4- and CD8-deficient background. T lymphocytes from these animals react to minute amounts (10-100 times less than control mice) of staphylococcal enterotoxin B (SEB) in vitro, similar to concentrations to which human cells react. In vivo, these double-transgenic, double-knockout mice succumb to normally sublethal amounts of SEB. This sensitivity is not due to a biased T cell receptor V beta repertoire, increased T cell reactivity, or increased sensitivity to macrophage-derived cytokines. Rather, tumor necrosis factor (TNF)-alpha production by T cells and serum levels of TNF-alpha correlate precisely with the clinical syndrome, showing a biphasic T cell-dependent response. These data show that both human CD4 and MHC class II molecules can render mice supersensitive to superantigen-induced septic shock syndrome. This animal model mimics the progression of septic shock in man by transforming normally resistant mice into hypersensitive SEB responders, a trait that is characteristic of humans. Mice that have been humanized by exchanging autochthonous superantigen ligands by their human equivalents may be useful to decipher superantigen responses in vivo and to assess the pathogenesis of superantigen-associated diseases.
Synthesis and Study of Hexanuclear Molybdenum Clusters Containing Thiolate Ligands (2008)

Four hexanuclear molybdenum chloride cluster complexes containing terminal thiolate ligands have been synthesized and fully characterized. (Bu 4N) 2[Mo 6Cl 8(SEt) 6] was prepared by reacting Na 2[Mo 6Cl 8(OMe) 6] with an excess of ethanethiol in refluxing tetrahydrofuran. (PPN) 2[Mo 6Cl 8(SBu) 6], (Bu 4N) 2[Mo 6Cl 8(SBn) 6], and (Bu 4N) 2[Mo 6Cl 8(SNC 8H 6) 6] (C 8H 6NS (-) = 3-indolylthiolate) were subsequently prepared in the reaction of [Mo 6Cl 8(SEt) 6] (2-) with an excess of HSR (R = Bu, Bn or 3-indolyl). Single crystal X-ray diffraction analyses were performed on two of these complexes: (PPN) 2[Mo 6Cl 8(SEt) 6].Et 2O, crystallizes in the triclinic space group P1 with a = 12.3894(11), b = 13.7651(12), c = 15.0974(13), alpha = 103.975(2), beta = 99.690(2), gamma = 98.062(2), and Z = 1; (PPh 3Me) 2[Mo 6Cl 8(SBn) 6].2NO 2CH 3, also crystallizes in the P1 space group with a = 12.1574(16), b = 13.4441(17), c = 14.2132(18), alpha = 89.654(2), beta = 88.365(2), gamma = 71.179(2), and Z = 1. Our studies demonstrate that [Mo 6Cl 8(SEt) 6] (2-) displays luminescent properties and that the same complex undergoes substitution reactions with different thiols, as well as reaction with electrophilic reagents such as MeI.
Comparison of Oral and Vaginal Metronidazole Therapy for Nonspecific Bacterial Vaginosis (1986)

A prospective, randomized, nonblind study was performed to compare the efficacy of a 7-day vaginal regimen with 500 mg metronidazole (Flagyl) once a day and that of oral treatment with 400 mg metronidazole twice daily for 7 days in the treatment of nonspecific bacterial vaginosis. No treatment was given to the sexual partners and there was no restriction of sexual intercourse. 38 women completed the study and at follow-up after 4 weeks, women receiving vaginal therapy had a cure rate of 79% compared with 74% in the women on oral therapy. Cure rates were lower among users of an intrauterine contraceptive device (57 versus 88% among nonusers). The occurrence of lactate-producing bacteria (lactobacilli and aerobic streptococci) in the vagina was significantly higher in women after vaginal compared with oral therapy. Gardnerella vaginalis was isolated in 58% of the women after vaginal and in 44% of the women after oral treatment. It is concluded that vaginal application of 500 mg metronidazole daily for 7 days is equally effective as oral administration in the treatment of bacterial vaginosis.