gebhart/patrepeval huggingface dataset:
Gamma-Secretase Inhibitor Treatment Promotes VEGF-A-Driven Blood Vessel Growth and Vascular Leakage but Disrupts Neovascular Perfusion (2011)

The Notch signaling pathway is essential for normal development due to its role in control of cell differentiation, proliferation and survival. It is also critically involved in tumorigenesis and cancer progression. A key enzyme in the activation of Notch signaling is the gamma-secretase protein complex and therefore, gamma-secretase inhibitors (GSIs)--originally developed for Alzheimer's disease--are now being evaluated in clinical trials for human malignancies. It is also clear that Notch plays an important role in angiogenesis driven by Vascular Endothelial Growth Factor A (VEGF-A)--a process instrumental for tumor growth and metastasis. The effect of GSIs on tumor vasculature has not been conclusively determined. Here we report that Compound X (CX), a GSI previously reported to potently inhibit Notch signaling in vitro and in vivo, promotes angiogenic sprouting in vitro and during developmental angiogenesis in mice. Furthermore, CX treatment suppresses tumor growth in a mouse model of renal carcinoma, leads to the formation of abnormal vessels and an increased tumor vascular density. Using a rabbit model of VEGF-A-driven angiogenesis in skeletal muscle, we demonstrate that CX treatment promotes abnormal blood vessel growth characterized by vessel occlusion, disrupted blood flow, and increased vascular leakage. Based on these findings, we propose a model for how GSIs and other Notch inhibitors disrupt tumor blood vessel perfusion, which might be useful for understanding this new class of anti-cancer agents.
REVIEWS OF BOOKS (1966)

Journal Article REVIEWS OF BOOKS Get access Le Frottole per Canto e Liuto Intabulate da Franciscus Bossinensis. By Benvenuto Disertori. pp. 631. ‘Istituzioni e Monumenti dell'Arte Musicale Italiana’, new series, Vol. III. ( Ricordi, Milan, 1964.) N. C. F N. C. F Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume 47, Issue 2, April 1966, Pages 166–167, https://doi.org/10.1093/ml/47.2.166 Published: 01 April 1966
Processing Transactions in a Predefined Order (2018)

In this paper we provide a high performance solution to the problem of committing transactions while enforcing a predefined order. We provide the design and implementation of three algorithms, which deploy a specialized cooperative transaction execution model. This model permits the propagation of written values along the chain of ordered transactions. We show that, even in the presence of data conflicts, the proposed algorithms are able to outperform single-threaded execution, and other baseline and specialized state-of-the-art competitors (e.g., STMLite). The maximum speedup achieved in micro benchmarks, STAMP, PARSEC and SPEC200 applications is in the range of 4.3x -- 16.5x.
Myocyte Redistribution of GRK2 and GRK5 in Hypertensive, Heart-Failure–Prone Rats (2002)

Gprotein-coupled receptor kinases (GRKs) are known to be involved in the development of cardiac hypertrophy. Their exact role and subcellular distribution during cardiac hypertrophy and failure remain to be elucidated. We examined expression and subcellular distribution of GRK2 and GRK5 in the left ventricle of female spontaneously hypertensive heart failure (SHHF) rats at 6 months of age using Western blots and fluorescent confocal microscopy. GRK2 was expressed mainly in the Triton X-100 soluble fraction in the left ventricle with similar expression levels between SHHF and age-matched Wistar-Kyoto (WKY) rats. GRK2 had a striated pattern which colocalized with sarcomeric alpha-actinin and G protein in both SHHF and WKY rat myocytes and specifically accumulated in the intercalated disks of myocytes from SHHF but not WKY rats. GRK5 was expressed in both the Triton X-100 soluble fraction and Triton X-100 insoluble fraction in the left ventricle with similar expression levels between SHHF and WKY rats. GRK5 distributed diffusely in the cytoplasm in both SHHF and WKY rat myocytes and specifically accumulated in the nucleus of myocytes from SHHF but not WKY rats. GRK5 colocalized with coilin, the major component of the nuclear substructure involved in RNA synthesis and processing. The results suggest different roles for GRK2 and GRK5 in G-protein signaling and RNA biogenesis. Subcellular redistribution of GRK2 and GRK5 may be involved in cardiac hypertrophy resulting from chronic hypertension.
Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice. (1995)

Transforming growth factor-beta 1 (TGF-beta 1) is a modulator of cellular proliferation, differentiation, and extracellular matrix deposition. It is a potent epithelial growth inhibitor and can alter the differentiative properties of keratinocytes, in vitro, but little is known about its normal physiological function in the epidermis in vivo. Transgenic mice were generated using a keratin 10 (K10) gene promoter to drive constitutive expression of TGF-beta 1 in the suprabasal keratinocyte compartment. Surprisingly, these mice showed a two- to threefold increase in epidermal DNA labeling index over control mice, in the absence of hyperplasia. The transgene, however, acted in the expected fashion, as a negative regulator of cell growth, when hyperplasia was induced by treatment by 12-tetradecanoyl-phorbol-13-acetate (TPA). Epidermal TGF-beta type I and II receptor (T beta RI and T beta RII) levels were examined in control and transgenic mice during induction of hyperplasia by TPA. Whereas T beta RI levels remained relatively constant, T beta RII expression was strongly induced in TPA-treated skins, prior to the induction of the growth inhibitory response to TGF-beta 1, and its level of expression correlated with growth sensitivity to TGF-beta 1 in vivo and in vitro. These results suggest that TGF-beta 1 and its type II receptor are part of the endogenous homeostatic regulatory machinery of the epidermis.
Some derivatives of morpholinophosphorodichloridate and dichloridothioate (1984)

Abstract Morpholinophosphorodichloridate and dichloridothioate reacted with amines (2 molar equivalents) to give the amidic chlorides which were treated with nucleophilic reagents to give sixty‐four derivatives. However the dichloridothioate with primary amines (1 molar equivalent) only gave diamidic thioates, the reasons for the failure to obtain the expected amidochloridothioates are briefly discussed.
Introduction (2013)

« En racontant comme homme public le plus grand événement de la Restauration, j’ai été obligé d’amener sur la scène les hommes publics qui furent en relation avec moi. » Le 1er janvier 1820, le général Riego prend la tête d’un soulèvement des troupes espagnoles destinées à partir réprimer les colonies américaines en pleine insurrection. À Cabezas de San Juan, il proclame la constitution de 1812, promulguée à l’époque de la guerre d’indépendance contre la France. Face à la progression de la ré...
Automated Treatment of Critically Ill Patients Following Operation (1968)

SHEPPARD, LOUIS C. B.S.; KOUCHOUKOS, NICHOLAS T. M.D.; KURTTS, MARY ALTA R.N.; KIRKLIN, JOHN W. M.D. Author Information
Facile synthesis of LDH nanoplates as reinforcing agents in PVA nanocomposites (2016)

In the present study, layered double hydroxide (LDH) nanoplates with high crystallinity and uniform size were facilely synthesized to act as reinforcing agents in polymer materials. The structure of the synthesized LDH nanoplates was characterized by X‐ray diffraction, Fourier transform infrared spectra, scanning electron microscopy, transmission electron microscopy, and atomic force microscopy measurements. Subsequently, the LDH nanoplates were incorporated into poly(vinyl alcohol) (PVA) matrix as reinforcing agents based on a solution casting method. The LDH nanoplates were well dispersed in PVA matrix and formed strong interfacial interactions with PVA chains, leading to remarkable improvements of thermal stability, flame retardancy, and mechanical properties. With the incorporation of 1 wt% LDH nanoplates into PVA, the T onset and T 50% increased by 11°C and 57°C, respectively. Moreover, the presence of LDH nanoplates decreases the decomposition rates of PVA and increases the amount of char residues. Compared with pure PVA, the peak heat release rate value of the PVA/5 wt% LDH nanocomposites is decreased by 52%. The tensile strength and the elongation at break increased by 71% and 187%, respectively, when incorporating with 3 wt% LDH nanoplates. Copyright © 2016 John Wiley & Sons, Ltd.
The Carboxyl-Terminal Half-Molecule of Ovotransferrin Prepared by Selective Digestion of the Amino-Terminal Lobe with Thermolysin (1992)

Diferric ovotransferrin was hydrolyzed by thermolysin, a thermostable protease, at elevated temperatures. At 65 degrees C, the amino(N)-terminal lobe was completely digested into small peptides, while the carboxyl(C)-terminal lobe was significantly resistant to the protease. This permitted the isolation of an iron-bound C-terminal half-molecule consisting of a glycosylated single polypeptide in an excellent yield (about 90%). The fragment comprises the residues from 336 to the C-terminus of ovotransferrin. The results for the visible absorption spectrum of the copper-bound fragment, the stability of the iron-bound fragment in high concentration of urea, and the CD spectra of the fragment in the far and near UV regions indicated that it retains the metal binding activity and conformation of the C-terminal lobe of intact ovotransferrin.
Preparation of high moment CoFe films with controlled grain size and coercivity (2005)

In this paper a preparation method for high moment CoFe thin films with soft magnetic properties is reported. A full control of coercivity in a series of 20-nm-thick CoFe films has been achieved without using seed layers, additives, or thermal annealing. The films were sputtered directly onto Si substrates and the coercivity was varied by changing the mean grain size in the sputtered films. The mean grain size was in turn controlled via the sputtering rate. A reduction in the coercivity has been observed from 120Oe for samples with a mean grain size larger than 17nm down to 12Oe for a sample with a mean grain size of 7.2nm. The results are in good agreement with the “random anisotropy model” relating the coercivity to the mean grain size in polycrystalline ferromagnetic films.
State-of-the-art in artificial neural network applications: A survey (2018)

This is a survey of neural network applications in the real-world scenario. It provides a taxonomy of artificial neural networks (ANNs) and furnish the reader with knowledge of current and emerging trends in ANN applications research and area of focus for researchers. Additionally, the study presents ANN application challenges, contributions, compare performances and critiques methods. The study covers many applications of ANN techniques in various disciplines which include computing, science, engineering, medicine, environmental, agriculture, mining, technology, climate, business, arts, and nanotechnology, etc. The study assesses ANN contributions, compare performances and critiques methods. The study found that neural-network models such as feedforward and feedback propagation artificial neural networks are performing better in its application to human problems. Therefore, we proposed feedforward and feedback propagation ANN models for research focus based on data analysis factors like accuracy, processing speed, latency, fault tolerance, volume, scalability, convergence, and performance. Moreover, we recommend that instead of applying a single method, future research can focus on combining ANN models into one network-wide application.
Untersuchungen zur Thiol/En‐Polymerisation: elektronenspinresonanzspektroskopischer Nachweis spontaner Radikalbildung (1991)

Abstract By means of ESR (electron spin resonance) spectroscopic investigations it is shown, that in dithiol/diene‐mixtures, in the absence of daylight and oxygen, radicals are formed spontaneously. Using the spin trapping technique and nitrosodurene (ND) as the trapping agent the existence of sulfur and carbon radicals could be proved unambiguously. Oxygen has no significant influence on the reaction. Spin trapping experiments have shown, that the aliphatic dithiols investigated do not form any traceable quantity of RS . and . OOH radicals in the presence of air. Radicals are detected only after addition of an ene‐compound.
Comparison of ad hoc and centralized multihop routing (2003)

In order to improve coverage and alleviate traffic congestion in single-hop cellular networks (SCN), such as GSM, a new radio network architecture, multihop cellular networks (MCN), was proposed and analyzed (see Lin, Y.D. et al., IEEE INFOCOM, 2000). MCN architecture can improve the coverage and system capacity of SCNs by up to 40%. A detailed concept for realizing the MCN architecture was suggested by R. Ananthapadmanabha, et al. (see Proc. PIMRC, 2001), where a cellular based multihop routing protocol was developed and investigated. Their results indicate that MCN with the cellular based routing protocol provides much higher system throughput than SCN. However the paper gave no reasons for using cellular based routing instead of the ad hoc multihop routing protocols specified by IETF (see www.ietf.org). This paper is intended to fill that gap with the help of an analysis of routing protocol efficiency. We compare a cellular based routing protocol with three ad hoc routing protocols, DSR, AODV and DSDV. Based on analytical results, it can be concluded that the overhead of the cellular based routing protocol is not heavily influenced by network size and mobility. This translates to excellent scalability for large and dynamic MCNs, while AODV, DSR and DSDV are suitable for MCNs with a small number of hops and low mobility.
A reed‐solomon coded optically preamplified PPM system (1995)

Abstract A Reed‐Solomon coded optically preamplified pulse‐position modulation system is analyzed. Results are presented at a bit rate of 622 Mbit/s and a wavelength of 1.537 μm, comparing the system with an equivalent on‐off nonreturn‐to‐zero (OOK NRZ) system. The theoretical results demonstrate that the system offers a potential sensitivity of 7 photons/bit, which represents an improvement of 7.5 dB over the equivalent OOK system and is comparable with that of the best coherent systems reported to date. © 1995 John Wiley & Sons, Inc.
Optically excited electron emission from silicon field emitter arrays (2000)

Summary form only given.We report on the measurements of efficient CW photo-induced emission from silicon tip arrays as well as its saturation behaviour and nanosecond scale temporal response. We fabricated field emission arrays on 500 /spl mu/m thick p-type silicon substrates. The silicon emitters were formed by using a dry etching process followed by oxidation sharpening.
Nanosecond-scale timing jitter for single photon detection in transition edge sensors (2013)

Transition edge sensors (TES) have the highest reported efficiencies (&gt;98%) for single photon detection in the visible and near infrared. Experiments in quantum information and foundations of physics that rely on this efficiency have started incorporating these detectors. However, their range of applicability has been hindered by slow operation both in recovery time and timing jitter. We show how a conventional tungsten-TES can be operated with jitter times of ≈4 ns, providing a practical simplification for experiments that rely on simultaneous high efficiency and low timing uncertainty, such as loophole free Bell inequalities and device independent quantum cryptography.
Efficient and effective path for automated dispensing of bio-precipitant solutions (2005)

There is a strong need for setting up high-throughput crystallization screens to determine the optimum conditions for protein crystal growth. In the protein structure determination process, it is required to prepare precipitant solutions to obtain well-diffraction quality crystals. In the precipitant solutions preparation procedure, a set of precipitating salts or polyethylene glycol, buffers and additives are delivered in a set of wells depending on the concentration and composition of precipitant solution. In this paper, we have implemented various heuristics to provide an efficient and effective path for the dispensing tip of robotic system to deliver the solutions for achieving high-throughput. An extensive analysis of these heuristics in providing sub-optimal paths for different precipitant solution setups is conducted. We have also presented results showing the improvement in total distance traveled by the robot in setting up precipitant solution preparation in the high-throughput mode.
Volcano-shaped field emitters for large area displays (2002)

Individual and groups of 3/spl times/3 and 10/spl times/10 gated volcano-shaped field emitters have been processed with gate dimensions of 4, 8, 14, 25 and 50 /spl mu/m and gate-to-emitter rim distances of 1.0 and 0.25 /spl mu/m. The 0.25 /spl mu/m devices are fabricated with a stepped oxide process which does not increase the gate-to-emitter capacitance significantly. Turn-on voltages range from 80-90 V for the 0.25 /spl mu/m devices and are about 250 V for the 1.0 /spl mu/m devices. I-V characteristics will be presented as well as an integration scheme for the formation of matrix-addressable arrays for field emitter display (FED) applications.
Design of a 10Gbps optical burst mode DPSK receiver for data and clock recovery (2008)

We present a 10Gbps DPSK burst mode receiver with zero latency clock synchronization. Concatenated phaseshift and resonator techniques maintain an NRZ data clock component over ≫1024 bit guard intervals.
Police Patrol service optimization based on the spatial pattern of hotspots (2011)

Many algorithms have been developed to optimize police patrol services. Previous studies have mainly focused on determining the important locations (e.g., crime hotspots) and identifying important routes based on the topology of road networks. However, the impact of the patterns of hotspots on patrol route selections and the collective performance of patrol activities were rarely considered in these studies. In addition, some algorithms lack a mechanism to ensure the randomness in patrolling and some are not efficient enough for real-time applications. In this study, we propose an approach to determine sets of patrol routes, which can help to optimize the collective efforts of multiple patrol activity. In our approach, we integrate the Getis-Ord Gi* with the Cross Entropy approach to produce randomized optimal patrol routes. We also address how to ensure the randomness in the route identification using the Cross Entropy approach. Our results indicate that our approach can help to improve the collective performance of police patrol service and it is also efficient enough for real-time application.
X‐Ray Imaging Technique for Observing Liquid Encapsulation Czochralski Crystal Growth (1974)

An imaging technique has been developed to facilitate growth of uniform diameter crystals by the liquid encapsulation Czochralski method. A point source of x‐rays is used to produce a shadow image of the growing crystal on a scintillation screen. A high‐sensitivity TV camera converts the shadow image into a real‐time display on a TV monitor. System components are described, and results obtained from growing GaP crystals are presented.
Omnidirectional Vision Systems: 1998 PI Report (1998)

Conventional video cameras have limited fields of view which make them restrictive in a variety of applications. Based on our previous work on omnidirectional imaging, we have developed a variety of new vision sensors, real-time algorithms for tracking and depth estimation and architectures for distributed surveillance. In this report, we briefly describe research projects that were completed during the 1997-1998 time frame. 1 Introduction This report describes a variety of VSAM projects that are based on, or related to, omnidirectional imaging technology we have developed [Nayar, 1997] , [Peri and Nayar, 1997] , [Nayar and Baker, 1997] , [Nayar and Boult, 1997] , [Nene and Nayar, 1998] , [Gluckman and Nayar, 1998a] , [Baker and Nayar, 1998] , [Boult, 1998a] . Broadly, our research projects can be divided into the following thrust areas: . Sensors: We have made significant advances in the area of wide field of view sensing. Our new devices include: a very compact, selfcontained, omn...
Mechanism for NO Photooxidation over the Oxygen-Deficient TiO2 Powder under Visible Light Irradiation (2000)

Abstract The mechanism for the photooxidation of NO over hydrogen plasma-treated TiO2 under visible light irradiation was studied by in situ Fourier transform infrared spectroscopy. It was found that the oxidation of NO over plasma-treated TiO2 under visible light proceeded consecutively as NO → NO2− → NO3−, where the oxidation process of NO2− to NO3− was newly created by irradiation of visible light.
Light Field Synthesis by Training Deep Network in the Refocused Image Domain (2020)

Light field imaging, which captures spatial-angular information of light incident on image sensors, enables many interesting applications such as image refocusing and augmented reality. However, due to the limited sensor resolution, a trade-off exists between the spatial and angular resolutions. To increase the angular resolution, view synthesis techniques have been adopted to generate new views from existing views. However, traditional learning-based view synthesis mainly considers the image quality of each view of the light field and neglects the quality of the refocused images. In this paper, we propose a new loss function called refocused image error (RIE) to address the issue. The main idea is that the image quality of the synthesized light field should be optimized in the refocused image domain because it is where the light field is viewed. We analyze the behavior of RIE in the spectral domain and test the performance of our approach against previous approaches on both real (INRIA) and software-rendered (HCI) light field datasets using objective assessment metrics such as MSE, MAE, PSNR, SSIM, and GMSD. Experimental results show that the light field generated by our method results in better refocused images than previous methods.
Wheat Straw-Derived N-, O-, and S-Tri-doped Porous Carbon with Ultrahigh Specific Surface Area for Lithium-Sulfur Batteries (2018)

Recently, lithium-sulfur (Li-S) batteries have been greeted by a huge ovation owing to their very high theoretical specific capacity (1675 mAh·g<sup>−1</sup>) and theoretical energy density (2600 Wh·kg<sup>−1</sup>). However, the full commercialization of Li-S batteries is still hindered by dramatic capacity fading resulting from the notorious “shuttle effect” of polysulfides. Herein, we first describe the development of a facile, inexpensive, and high-producing strategy for the fabrication of N-, O-, and S-tri-doped porous carbon (NOSPC) via pyrolysis of natural wheat straw, followed by KOH activation. The as-obtained NOSPC shows characteristic features of a highly porous carbon frame, ultrahigh specific surface area (3101.8 m²·g<sup>−1</sup>), large pore volume (1.92 cm³·g<sup>−1</sup>), good electrical conductivity, and in situ nitrogen (1.36 at %), oxygen (7.43 at %), and sulfur (0.7 at %) tri-doping. The NOSPC is afterwards selected to fabricate the NOSPC-sulfur (NOSPC/S) composite for the Li-S batteries cathode material. The as-prepared NOSPC/S cathode delivers a large initial discharge capacity (1049.2 mAh·g<sup>−1</sup> at 0.2 C), good cycling stability (retains a reversible capacity of 454.7 mAh·g<sup>−1</sup> over 500 cycles at 1 C with a low capacity decay of 0.088% per cycle), and superior rate performance (619.2 mAh·g<sup>−1</sup> at 2 C). The excellent electrochemical performance is mainly attributed to the synergistic effects of structural restriction and multidimensional chemical adsorptions for cooperatively repressing the polysulfides shuttle.