gebhart/patrepeval huggingface dataset:
Serum hyaluronan - a non-invasive test for diagnosing liver cirrhosis (2000)

Measurement of fasted serum hyaluronan reliably differentiated cirrhotic from non-cirrhotic liver disease and can be regarded as a useful test in the diagnosis of liver cirrhosis, particularly when a liver biopsy is contraindicated.
Analysis and Assessment on Nutritional Quality of Spinach (Spinacia oleracea L.) Varieties from Different Sources (2009)

To screen spinach(Spinacia oleracea L.)varieties which rich in nutrition and low in nitrate,tannin and oxalate,the nutritional quality of 34 spinach varieties from different sources were evaluated by measuring the quality parameters including water content,VC,soluble sugar,crude fiber,oxalate,tannin and nitrate.Then they were analyzed by means of fuzzy membership function.The results showed that the quality of different spinach varieties had great differences.Among the varieties evaluated here,'Jingbo No.1'exhibited excellent nutrient quality with highest VC content,reaching 601.0 mg·kg-1(FW),and least nitrate content.Besides,'Shengxianfeng','トライ'and'アソナ'were the best varieties in comprehensive quality with better promotion prospects for application.
Role of Cholinesterase Inhibitors in Parkinson’s Disease and dementia with Lewy Bodies (2004)

This article reviews the cholinergic changes in Parkinson's disease and dementia (PDD) and dementia with Lewy bodies (DLB), their potential clinical implications, and the available evidence for cholinesterase inhibitors in the treatment of PDD and DLB. Marked neuronal loss of cholinergic nuclei, reduced cholinergic markers in the neocortex, hippocampus, and selected thalamic nuclei, and receptor changes have been reported. One large and 2 small placebo-controlled trials and nearly 20 open-label studies suggest that cholinesterase inhibitors have a positive effect on cognition, psychiatric symptoms, and global function in patients with DLB and PDD. The treatment is well tolerated in most patients without any apparent worsening of extrapyramidal motor features. Given the high risk of severe sensitivity reactions and increased risk of cerebrovascular incidents during treatment with neuroleptics, more clinical trials of cholinesterase inhibitors are encouraged to establish their precise role in DLB and PDD.
Intensive Nutrition in Acute Lung Injury (2014)

Provision of IMNT from ALI diagnosis to hospital discharge increases mortality.
Adaptive filters for continuous queries over distributed data streams (2003)

We consider an environment where distributed data sources continuously stream updates to a centralized processor that monitors continuous queries over the distributed data. Significant communication overhead is incurred in the presence of rapid update streams, and we propose a new technique for reducing the overhead. Users register continuous queries with precision requirements at the central stream processor, which installs filters at remote data sources. The filters adapt to changing conditions to minimize stream rates while guaranteeing that all continuous queries still receive the updates necessary to provide answers of adequate precision at all times. Our approach enables applications to trade precision for communication overhead at a fine granularity by individually adjusting the precision constraints of continuous queries over streams in a multi-query workload. Through experiments performed on synthetic data simulations and a real network monitoring implementation, we demonstrate the effectiveness of our approach in achieving low communication overhead compared with alternate approaches.
Die Reaktionen von M[BF<sub>4</sub>] (M = Li, K) und (C<sub>2</sub>H<sub>5</sub>)<sub>2</sub>O·BF<sub>3</sub> mit (CH<sub>3</sub>)<sub>3</sub>SiCN. Bildung von M[BF<sub>x</sub>>(CN)<sub>4—x</sub>] (M = Li, K; x = 1, 2) und (CH<sub>3</sub>)<sub>3</sub>SiNCBF<sub>x</sub>(CN)<sub>3—x</sub>, (x = 0, 1) (2003)

Abstract Die Reaktion von M[BF 4 ] (M = Li, K) mit (CH 3 ) 3 SiCN führt je nach Reaktionsdauer und Temperatur selektiv zu den gemischten Cyanofluoroboraten M[BF x (CN) 4—x ] (x = 1, 2; M = Li, K). Unter Verwendung von (C 2 H 5 ) 2 O·BF 3 gelingt die Synthese von (CH 3 ) 3 SiNCBF x (CN) 3—x (x = 0, 1). Die Charakterisierung der beschriebenen Verbindungen erfolgt anhand von Schwingungs‐ und NMR‐Spektren sowie durch Röntgenstrahlbeugung an Einkristallen: Li[BF 2 (CN) 2 ]·2Me 3 SiCN Cmc2 1 , a = 24.0851(5), b = 12.8829(3), c = 18.9139(5) Å, V = 5868.7(2) Å 3 , Z = 12, R 1 = 4, 7%; K[BF 2 (CN) 2 ] P4 1 2 1 2, a = 13.1596(3), c = 38.4183(8) Å, V = 6653.1(3) Å 3 , Z = 48, R 1 = 2, 5%; K[BF(CN) 3 ] P1, a = 6.519(1), b = 7.319(1), c = 7.633(2) Å, α = 68.02(3), β = 74.70(3), γ = 89.09(3)°, V = 324.3(1) Å 3 , Z = 2, R 1 = 3.6%; Me 3 SiNCBF(CN) 2 Pbca, a = 9.1838(6), b = 13.3094(8), c = 16.840(1)Å, V = 2058.4(2)Å 3 , Z = 8, R 1 = 4, 4%
Targeting L1 cell adhesion molecule expression using liposome-encapsulated siRNA suppresses prostate cancer bone metastasis and growth (2014)

The L1 cell adhesion molecule (L1CAM) has been implicated in tumor progression of many types of cancers, but its role in prostate cancer and its application in targeted gene therapy have not been investigated. Herein, we demonstrated that the L1CAM was expressed in androgen-insensitive and highly metastatic human prostate cancer cell lines. The correlation between L1CAM expression and prostate cancer metastasis was also validated in serum samples of prostate cancer patients. Knockdown of L1CAM expression in prostate cancer cells by RNA interference significantly decreased their aggressive behaviors, including colony formation, migration and invasion in vitro, and tumor formation in a metastatic murine model. These anti-malignant phenotypes of L1CAM-knockdown cancer cells were accompanied by G0/G1 cell cycle arrest and suppression of matrix metalloproteinase (MMP)-2 and MMP-9 expression and nuclear factor NF-κB activation. In vivo targeting of L1CAM expression using liposome-encapsulated L1CAM siRNAs effectively inhibited prostate cancer growth in mouse bone, which was associated with decreased L1CAM expression and cell proliferation by tumor cells. These results provide the first evidence for L1CAM being a major contributor to prostate cancer metastasis and translational application of siRNA-based L1CAM-targeted therapy.
Synthesis and crystal growth of zeolite SZM-5 from sodium aluminosilicate systems free of Hachinohe, Aomori (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and crystal growth of zeolite SZM-5 from sodium aluminosilicate systems free of Hachinohe, AomoriEiichi Narita, Keiichi Sato, Noboru Yatabe, and Taijiro OkabeCite this: Ind. Eng. Chem. Prod. Res. Dev. 1985, 24, 4, 507–512Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://pubs.acs.org/doi/10.1021/i300020a004https://doi.org/10.1021/i300020a004research-articleACS PublicationsRequest reuse permissionsArticle Views358Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Autophagy Negatively Regulates Keratinocyte Inflammatory Responses via Scaffolding Protein p62/SQSTM1 (2010)

The scaffolding adaptor protein p62/SQSTM1 (p62) has been shown to be an autophagy receptor that acts as a link between the ubiquitination and autophagy machineries. However, the roles of autophagy and p62 in human keratinocytes are not well understood. In this study, we show that keratinocyte autophagy negatively regulates p62 expression, which is essential for the prevention of excessive inflammation and the induction of cathelicidin in human keratinocytes. Stimulation of TLR2/6 or TLR4 in primary human keratinocytes robustly activated autophagy pathways and up-regulated p62 expression through induction of NADPH oxidases 2 and 4 and the generation of reactive oxygen species. MyD88 and TNFR-associated factor 6, key signaling molecules that mediate TLR activation, played an essential role in the induction of autophagy and p62 expression. Additionally, blockade of autophagy significantly increased the generation of inflammatory cytokines and expression of p62 in primary human keratinocytes. Notably, silencing hp62 through RNA interference resulted in a significant decrease in NF-κB activation, inflammatory cytokine production, cathelicidin expression, and cell proliferation (as well as cyclin D1 expression) in keratinocytes. Epidermal expression of p62 was further found to be significantly higher in psoriatic skin than in skin affected by atopic dermatitis or from healthy controls. Collectively, our data provide new insights into the roles of autophagy and p62 in controlling cutaneous inflammation.
Well‐Defined Nanofibers with Tunable Morphology from Spherical Colloidal Building Blocks (2013)

From particles to fibers: Nanofibers with different morphologies and periodicities can be fabricated by supraparticular assembly of magnetic spherical nanoparticles. A linear sintering process is used to merge the assembled colloids together. The structure of the obtained fibers is controlled by the process parameters and the morphology of the spherical colloidal building blocks.
Optimizing password composition policies (2013)

A password composition policy restricts the space of allowable passwords to eliminate weak passwords that are vulnerable to statistical guessing attacks. Usability studies have demonstrated that existing password composition policies can sometimes result in weaker password distributions; hence a more principled approach is needed. We introduce the first theoretical model for optimizing password composition policies. We study the computational and sample complexity of this problem under different assumptions on the structure of policies and on users' preferences over passwords. Our main positive result is an algorithm that -- with high probability --- constructs almost optimal policies (which are specified as a union of subsets of allowed passwords), and requires only a small number of samples of users' preferred passwords. We complement our theoretical results with simulations using a real-world dataset of 32 million passwords.
p95, the major phosphotyrosine-containing protein in mouse spermatozoa, is a hexokinase with unique properties. (1994)

Mouse sperm contain a major phosphotyrosine-containing protein of M(r) 95,000 (nonreducing conditions) which has been implicated as a sperm membrane receptor for the egg zona pellucida glycoprotein, ZP3 (Leyton, L., and Saling, P. (1989) Cell 57, 1123-1130; Leyton, L., LeGuen, P., Bunch, D., and Saling, P. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 11692-11695). This protein was purified and subjected to limited tryptic digestion and subsequent amino acid analysis. Three sequenced peptides revealed 100% amino acid identity to a mouse hepatoma hexokinase (Arora, K. K., Fanciulli, M., and Pederson, P. L. (1990) J. Biol. Chem. 265, 6481-6488). The purified protein, which migrated at M(r) 116,000 under reducing conditions (p95/116), reacted with an antiserum to the purified rat brain hexokinase, type 1, and comigrated on sodium dodecyl sulfate-polyacrylamide gel electrophoresis with the purified rat brain enzyme under both nonreducing and reducing conditions. Unlike p95/116, the rat brain enzyme was not a phosphotyrosine-containing protein. The p95/116 protein could be immunoprecipitated with the hexokinase antiserum or an O-phosphotyrosine antibody. Limited tryptic digestion of the purified p95/116 and the rat brain enzyme generated subsets of identical peptides which reacted with the hexokinase antiserum. However, p95/116 also contained phosphotyrosine-containing peptides that were not present in the rat brain hexokinase. When different mouse tissues were probed with the hexokinase antiserum all tissues, with the exception of liver, contained immunoreactive protein. In contrast, only sperm and testis possessed a phosphotyrosine-containing form of hexokinase. These data suggest that the germ cell component of the testis possesses a unique tyrosine-phosphorylated form of hexokinase.
Triple Chamber Pacemaker for End‐Stage Heart Failure in a Patient with a Previously Implanted Automatic Defibrillator (1998)

A 63-year-old man with an ischemic dilated cardiomyopathy previously implanted with an implantable cardioverter defibrillator (ICD) received a triple chamber pacemaker as an ultimate therapeutic resort for end-stage congestive heart failure. After implant, the tolerance to physical exercise increased and NYHA class decreased from III to II. Echocardiography assessed ventricular contraction resynchronization during DDD biventricular pacing as compared to VVI pacing. No major pacemaker-ICD interaction was noted during testing or follow-up. We conclude that sequential biventricular pacing is feasible in the presence of an ICD.
An Antiproliferative Genetic Screening Identifies a Peptide Aptamer That Targets Calcineurin and Up-regulates Its Activity (2006)

Peptide aptamers are combinatorial recognition molecules that consist of a constant scaffold protein displaying a doubly constrained variable peptide loop. They bind specifically target proteins and interfere with their function. We have built a peptide aptamer library in a lentiviral expression system to isolate aptamers that inhibit cell proliferation in vitro. Using one of the isolated aptamers (R5G42) as a bait protein, we have performed yeast two-hybrid screening of cDNA libraries and identified calcineurin A as a target protein candidate. R5G42 bound calcineurin A in vitro and stimulated its phosphatase activity. When expressed transiently in human cells, R5G42 induced the dephosphorylation of BAD. We have identified an antiproliferative peptide aptamer that binds calcineurin and stimulates its activity. The use of this ligand may help elucidate the still elusive structural mechanisms of activation and inhibition of calcineurin. Our work illustrates the power of phenotypic screening of combinatorial protein libraries to interrogate the proteome and chart molecular regulatory networks.
Porous Cu–BTC silica monoliths as efficient heterogeneous catalysts for the selective oxidation of alkylbenzenes (2014)

Macro-/mesoporous silica supported Cu–BTC monoliths were <italic>in situ</italic> synthesized as efficient reusable heterogeneous catalysts for the selective oxidation from alkylbenzenes to ketones with moderate to excellent yields. The catalytic selectivity of such low-cost catalysts due to the sizes and shapes of the substrates.
Anodizing Treatments for Magnesium Alloys and Their Effect on Corrosion Resistance in Various Environments (2006)

Abstract This paper reviews various aspects of anodizing of magnesium alloys, such as the basics, processes, properties and applications. It systematically summarises the existing fundamental studies and technical developments of anodizing of magnesium alloys, and concludes that new anodizing processes based on electrolytic plasma anodizing that convert the surface of a magnesium alloy into a hard ceramic coating in an electrolytic bath using high energy electric discharges can offer improved wear and corrosion resistance. These new anodized coatings are often claimed to perform better than the traditional ones obtained through older anodizing processes, such as DOW17 or HAE. The new anodizing techniques are chromate free and hence environment friendly. It is expected that more cost‐effective, environment‐friendly and non‐toxic anodizing techniques will be developed and applied to magnesium alloy components in the future.
Ferroelectric domain inversion in congruent lithium niobate (2004)

We present results of ferroelectric domain inversion studies in congruent lithium niobate which clarify some important aspects of the dynamics of the process such as the alignment of the internal electric field, initiation of poling, switching time, conditions for spontaneous backswitching and stabilization of inverted domains, and the influence of the impedance of the poling apparatus. These results are of practical interest for designing poling processes for the fabrication of periodically-poled lithium niobate.
Privacy-Preserving Federated Data Sharing (2019)

Consider a set of agents with sensitive datasets who are interested in the same prediction task and would like to share their datasets without revealing private information. For instance, the agents may be medical centers with their own historical databases and the task may be the diagnosis of a rare form of a disease. This paper investigates whether sharing privacy-preserving versions of these datasets may improve the agent predictions. It proposes a Privacy-preserving Federated Data Sharing (PFDS) protocol that each agent can run locally to produce a privacy-preserving version of its original dataset. The PFDS protocol is evaluated on several standard prediction tasks and experimental results demonstrate the potential of sharing privacy- preserving datasets to produce accurate predictors.
Synthesis of Vinca Alkaloids and Related Compounds XXXV1. Preparation of 1-Ethyl-1-hydroxyethyl-octahydroindolo[2,3-a]quinolizine Derivatives and Reactions of Their Mesylates with Cyanide Ion (1988)

Starting from (2)-eburnamonine (la) and (2)-3-epieburnamonine ----( & ) .conpounds 5 and 11 were prepared.The reaction of the mesylate of 5 or 11 with NaCN in DMIF led to a mixture of 16 and 17.The structures of
Heteroduplex Analysis (1998)

Glycogen storage disease type Ia (GSDIa), also known as von Gierke disease, is the most common and severe disease of glycogenoses and is caused by a deficiency of glucose-6-phosphatase (G6Pase) and transmitted by an autosomal recessive trait. The encoding gene of G6Pase is composed of only five exons and each exon is short. With heteroduplex analysis (HDA) method, we analyzed the genomic DNA from a patient diagnosed with GSDIa and from her parents. Exons II and IV of the patient showed heteroduplex bands. The mother had a heteroduplex band of exon II, and the father had a heteroduplex band of exon IV. In a mini-slab electrophoresis, exons II and IV of the patient did not show clear heteroduplex bands, but they appeared broader than the others, which made us suspect that they were heteroduplex bands. HDA is an easy and simple method and can verify mutant homozygous DNA fragments by adding wild-type DNA. We think that HDA may be a very useful screening method for the detection of novel genomic mutation in GSDIa in large-scale and mini-slab electrophoresis.
NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors (2020)

Determining mechanisms of resistance to αPD-1/PD-L1 immune-checkpoint immunotherapy is key to developing new treatment strategies. Cancer-associated fibroblasts (CAF) have many tumor-promoting functions and promote immune evasion through multiple mechanisms, but as yet, no CAF-specific inhibitors are clinically available. Here we generated CAF-rich murine tumor models (TC1, MC38, and 4T1) to investigate how CAFs influence the immune microenvironment and affect response to different immunotherapy modalities [anticancer vaccination, TC1 (HPV E7 DNA vaccine), αPD-1, and MC38] and found that CAFs broadly suppressed response by specifically excluding CD8<sup>+</sup> T cells from tumors (not CD4<sup>+</sup> T cells or macrophages); CD8<sup>+</sup> T-cell exclusion was similarly present in CAF-rich human tumors. RNA sequencing of CD8<sup>+</sup> T cells from CAF-rich murine tumors and immunochemistry analysis of human tumors identified significant upregulation of CTLA-4 in the absence of other exhaustion markers; inhibiting CTLA-4 with a nondepleting antibody overcame the CD8<sup>+</sup> T-cell exclusion effect without affecting Tregs. We then examined the potential for CAF targeting, focusing on the ROS-producing enzyme NOX4, which is upregulated by CAF in many human cancers, and compared this with TGFβ1 inhibition, a key regulator of the CAF phenotype. siRNA knockdown or pharmacologic inhibition [GKT137831 (Setanaxib)] of NOX4 "normalized" CAF to a quiescent phenotype and promoted intratumoral CD8<sup>+</sup> T-cell infiltration, overcoming the exclusion effect; TGFβ1 inhibition could prevent, but not reverse, CAF differentiation. Finally, NOX4 inhibition restored immunotherapy response in CAF-rich tumors. These findings demonstrate that CAF-mediated immunotherapy resistance can be effectively overcome through NOX4 inhibition and could improve outcome in a broad range of cancers. SIGNIFICANCE: NOX4 is critical for maintaining the immune-suppressive CAF phenotype in tumors. Pharmacologic inhibition of NOX4 potentiates immunotherapy by overcoming CAF-mediated CD8<sup>+</sup> T-cell exclusion. GRAPHICAL ABSTRACT: http://cancerres.aacrjournals.org/content/canres/80/9/1846/F1.large.jpg.<i>See related commentary by Hayward, p. 1799</i>.
Inner ear hair cells produced <i>in vitro</i> by a mesenchymal-to-epithelial transition (2007)

Sensory hair cell loss is a major contributor to disabling hearing and balance deficits that affect >250 million people worldwide. Sound exposures, infections, drug toxicity, genetic disorders, and aging all can cause hair cell loss and lead to permanent sensory deficits. Progress toward treatments for these deficits has been limited, in part because hair cells have only been obtainable via microdissection of the anatomically complex internal ear. Attempts to produce hair cells in vitro have resulted in reports of some success but have required transplantation into embryonic ears or coculturing with other tissues. Here, we show that avian inner ear cells can be cultured and passaged for months, frozen, and expanded to large numbers without other tissues. At any point from passage 6 up to at least passage 23, these cultures can be fully dissociated and then aggregated in suspension to induce a mesenchymal-to-epithelial transition that reliably yields new polarized sensory epithelia. Those epithelia develop numerous hair cells that are crowned by hair bundles, composed of a single kinocilium and an asymmetric array of stereocilia. These hair cells exhibit rapid permeance to FM1-43, a dye that passes through open mechanotransducing channels. Because a vial of frozen cells can now provide the capacity to produce bona fide hair cells completely in vitro , these discoveries should open new avenues of research that may ultimately contribute to better treatments for hearing loss and other inner ear disorders.
Crosslink Reaction Mechanisms of Diene Rubber with Dicumyl Peroxide (1996)

Abstract The scope of this paper is to review peroxide curing of diene elastomers. At high dicumyl peroxide loading and high curing temperature, changes in the crosslinking mechanisms were observed. Both Abstraction of allylic hydrogen and addition to the double bond can act as mechanisms of crosslinking. IR spectroscopy reveals a significant decrease in double bonds, and a new relaxation at temperatures above the T g of the elastomers is present.