gebhart/patrepeval huggingface dataset:
A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor (1995)

Many cytokines and soluble cytokine receptors are generated by limited proteolysis of membrane-bound precursors. We have examined the ability of the recently described metalloprotease inhibitor, TNF-alpha protease inhibitor (TAPI), and other protease inhibitors to modulate shedding. The membrane-bound forms of the ligands TNF-alpha and CSF-1, the p60 TNFR and the IL-6R, were expressed in COS-7 cells. As expected, TAPI blocked the spontaneous and PMA-induced release of TNF-alpha from transfected cells. Interestingly, TAPI also inhibited the release of soluble forms of p60 TNFR and IL-6R in COS-7 cells. However, the processing of CSF-1, which also requires proteolytic cleavage of a membrane protein, was not affected. The ability of TAPI to inhibit shedding was unique, since several other classes of protease inhibitors, including three other metalloprotease inhibitors, did not inhibit shedding of IL-6R. To determine whether TAPI would prevent shedding under more physiologic conditions, we demonstrated that TAPI was able to prevent unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. In addition, TAPI was able to inhibit LPS-induced shedding of the p60 TNFR and TNF-alpha from monocytes. In summary, our results indicate that a metalloprotease or group of related metalloproteases is responsible for the proteolytic cleavage of several cell surface proteins.
Photoinitiators with Functional Groups. Part I. Polymer Photoinitiators (1991)

Abstract A series of new polymerizable photoinitiators (PIs) based on hydroxyalkylphenones has been synthesized by Grignard reaction of 4-vinylphenylmagnesiumchloride with suitable carbonyl compounds. Radical homopolymerization and copolymerization of the PIS with various vinyl monomers yielded polymer PIS compatible with either hydrophilic or hydrophobic resin systems. The PI monomers and polymers are characterized by excellent photoinitiating activity comparable with the most efficient known PIS and exhibit high migration stability.
A Brief Survey of Right- and Left-Handedness (1917)

(1917). A Brief Survey of Right- and Left-Handedness. The Pedagogical Seminary: Vol. 24, No. 1, pp. 19-35.
가정간호분야 간호진단 분류체계 및 사정도구 분석 (2001)

Nursing diagnosis classification is needed to define nursing phenomena and set up nursing plans. The purpose of this study is to develope common nursing diagnosis by comparing and analysing nursing diagnosis classification systems and assessment tools in home care. The target home care nursing diagn...
Radiographic Evaluation of Periradicular Repair after Endodontic Treatment of Dog's Teeth with Induced Periradicular Periodontitis (2001)

Eighty-four root canals of premolars from six dogs were left open for 7 days, and then sealed and followed for 45 days until periradicular periodontitis developed. The root canals were then treated endodontically using 5.25% sodium hypochlorite as the irrigating solution. After instrumentation, all root canals were filled with a calcium hydroxide-based antibacterial dressing (Calen PMCC or Calasept) that was left in place for 30 days. After this period the root canals were filled with gutta-percha cones and a root canal sealer (Sealapex or AH Plus)--group I: Calen PMCC + Sealapex; group II: Calasept + Sealapex; group III: Calen PMCC + AH Plus; and group IV: Calasept + AH Plus. Periapical radiographs of the teeth were made after root canal filling and after 90, 180, 270, and 360 days. Radiographic images were digitalized by scanning, and the Mocha program was used to measure the periapical lesions. Analysis showed that the lesions of groups I to III were statistically similar reduction in size, whereas group IV had a smaller reduction in lesion size (p < 0.05).
Interleukin 21 Enhances Antibody-Mediated Tumor Rejection (2008)

Interleukin-21 (IL-21) is a cytokine with structural and sequence homology to IL-2 and IL-15 that has antitumor activity alone in mouse experimental tumor models and a tolerable safety profile in phase I trials in patients with metastatic melanoma and renal cell carcinoma. Several monoclonal antibodies (mAb) targeted at tumor-associated antigens also have improved antitumor activities in mice when used in combination with IL-21. Recently, we described a rational three antibody-based approach (triple mAb, TrimAb) to eradicating established mouse tumors that required the generation of tumor-reactive CD8(+) T cells and IFN-gamma. Herein, we show that sequentially combining TrimAb with recombinant IL-21 can significantly improve the antitumor activity of this combination against very advanced disease. These data further support the use of IL-21 in adjuvant settings where strong T cell-mediated immune responses to tumors can be generated.
Adapting Golog for Programming the Semantic Web (2001)

Motivated by the problem of automatically composing network accessible services, such as those on the World Wide Web, this paper proposes an approach to building agent technology based on the the notion of generic procedures and customizing user constraint. We argue that an augmented version of the logic programming language Golog provides a natural formalism for programming Web services. To this end, we adapt and extend the Golog language to enable programs that are generic, customizable and usable in the context of the Web. We realize these extensions in an augmented ConGolog interpreter that combines online execution of information-providing Web services with offline simulation of world-altering Web services, to determine a sequence of Web Services for subsequent execution. Our implemented system is currently interacting with services on the Web. 1
Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during hepatocarcinogenesis. (1997)

The liver is remarkably insensitive to a variety of cytotoxins and expresses a number of known drug resistance genes. To isolate new P-glycoprotein (Pgp)-related genes, we screened a normal rat liver cDNA library at low stringency with a MDR1 cDNA fragment containing the P-loop and ATP binding site. We isolated a novel cDNA closely related to the Pgps that is dramatically increased in hepatic neoplasia and refer to it as P-glycoprotein-related protein (PRP). The predicted protein shows PRP to be a member of the ATP-Binding Cassette (ABC) family of proteins, and a multisequence comparison of the nucleotide binding domain and the ABC family signature sequences reveals that PRP sequences are highly conserved with the greatest similarity to the yeast heavy metal transporter encoded by hmtl. However, the hydropathy plot analysis suggests that PRP does not have any prominent membrane-spanning domains and thus is not typical of ABC transporters. The PRP transcript is detected in many normal tissues. In the H35 hepatoma cell line, PRP was overexpressed compared to normal liver. Southern blot analysis of DNA from the H35 rat hepatoma cells reveals that the PRP gene was amplified compared to normal liver. The orotic acid model of hepatocarcinogenesis was used to determine if during stepwise progression to liver cancer, PRP changed with hepatocarcinogenesis. At the hyperplastic nodule stage, PRP expression was increased over its expression in normal surrounding liver. More dramatic increases in PRP expression were found in frank hepatic carcinomas. Cumulatively, these studies are the first to link a novel ABC family member to the hepatic neoplastic process, a role that may be recapitulated in other cells, considering the ubiquitous expression of PRP.
Research of Bittern Transportation Pipeline (2008)

There is the techniques of normal temperature and obturation and continuum,which this pipeline projects adopts the initial station opens pumps to the terminal station.there are only the initial station and the terminal station in the whole pipelines according to the design numbers of transportation and the assured pipeline diameters.The bittern transportation pipeline from Huai'an to Lianyungang alkali factory is taken as an example,the methods of design and calculation for the bittern transportation pipeline engineering are analyzed and discussed,the choice and the antisepsis of the pipeline materials are analyzed as important problemns,to which more attention should be paid,to provide reference just for other bittern transportation pipelines.
674. The mechanism and scope of an N-oxide rearrangement (1960)

M. S. Habib and C. W. Rees, J. Chem. Soc., 1960, 3371 DOI: 10.1039/JR9600003371
RFID Passive Gas Sensor Integrating Carbon Nanotubes (2011)

Carbon nanotube (CNT) composites are sensitive to the presence of gases due to their high surface-to-volume ratio and hollow structure that are well suited for gas molecule absorption and storage. Such sensing capability is here integrated with UHF RF identification (RFID) technology to achieve passive and low-cost sensors, remotely readable. CNT film (buckypaper) is used as a localized variable resistive load integrated into a tag antenna, which becomes able to transduce the presence of hazardous gas in the environment, ammonia in this case, into a change of its electromagnetic features. The dynamic range and the hysteresis of the radio sensor are investigated by simulations, equivalent circuits, and articulated experimentations within a true RFID link, providing the proof of concept and some guidelines for tag design.
Accurate MIMO Channel Modeling: Correlation Tensor vs. Directional Approaches (2007)

The ability of correlation tensor and directional modeling strategies to accurately capture the spatial behavior of multiple-input multiple-output (MIMO) channels is investigated. Correlation tensor methods are based on the reduced order approximations of the full channel covariance, and do not require any a priori knowledge about the physical scattering mechanism or antenna array. Directional methods require knowledge about the array configuration and usually assume a double-directional wave-propagation mechanism. Five different tensor methods (Kronecker, separable maximum entropy, Weichselberger, principal hyperplane, and sparse core tensor) and one directional method (unstructured diffuse spectrum estimation) are compared in terms of the number of parameters required and the match to the true full covariance matrix. Simulations with a realistic cluster channel model indicate that tensor methods suffer from poor accuracy when too few values in the core tensor are retained, especially when no joint transmit/receive information is available. The directional method, on the other hand, has good accuracy with the same number of parameters as the simplest tensor model. The results stress the importance of including joint transmit/receive information in MIMO models and suggest that directional modeling is a logical choice for high accuracy modeling with few parameters.
The use of amisulpride in the treatment of acute psychosis (2007)

The management of acute episodes in schizophrenia is frequently initiated in the psychiatric emergency department and requires rapid intervention to relieve distress and psychiatric symptoms. Both non-pharmacological and pharmacological interventions are needed to calm the patient and prevent potential harm to the patient or others. Treatment is a step-by-step process including management of behavioral symptomatology, diagnosis of potential organic causes, and evaluation of potential substance abuse. Better care is delivered if predefined standard operating procedures are adopted systematically. The ultimate goal of treatment is to establish a therapeutic alliance with the patient. Atypical antipsychotics given orally are recommended as a first-line treatment. As the treatment endpoint is calmness rather than sleep, a non-sedative antipsychotic agent is usually preferred. Drug tolerance is a major issue for the patient. Amisulpride is an effective atypical antipsychotic agent in this context. The optimal dose is 800 mg/day, which is effective on positive and negative symptoms and can be given from the first day with a low risk of extrapyramidal symptoms. Since drug-drug interactions are limited, agitation and anxiety may be controlled by short-term adjunctive therapy with benzodiazepines. In conclusion, amisulpride is an appropriate first-line treatment for the management of acute psychosis.
Optically stimulated luminescence in KMgF/sub 3/:Ce/sup 3+/ comparison of dosimetric characteristics with Al/sub 2/O/sub 3/:C (2001)

Ce/sup 3+/ doped KMgF/sub 3/ crystals have been investigated as a new material for dosimetry of ionizing radiation. Previous studies have focused on their thermoluminescence (TL) properties. This paper shows that the stored energy in this compound can also be read by visible light. Its sensitivity was found to be one order of magnitude greater than Al/sub 2/O/sub 3/:C, which can be considered as the standard dosimetric material based on optically stimulated luminescence (OSL). The greater sensitivity was due to a larger wavelength difference between stimulation and emission wavelengths, which results in a better separation of useful signal from scattered light. Time response characteristics were also significantly better than Al/sub 2/O/sub 3/:C, which allows in principle fast pulsed and multiple readouts. Unfortunately, the high self-dose (/spl sim/1.5 /spl mu/Gy/h) due to the natural abundance of /sup 40/K isotope is a major drawback for the application of this material in environmental dosimetry. Some features of the mechanism have been studied with different spectroscopic techniques. The luminescent centers have been clearly identified with Ce/sup 3+/ ions. It has been shown that the main trapping centers involved in OSL mechanism are the same as those involved in TL mechanism.
Phonetool: integrating telephones and workstations (2003)

The authors argue for computer workstation access to voice telephony functions. They describe several computer-based communication tools developed in their laboratories, and explore one, Phonetool, as a detailed example. They discuss user interface issues for collections of such utilities. Finally, they discuss several architectures for interaction with the PBX and the communication requirements between workstation and switch.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Treatment of cerebral vasospasm with self-expandable retrievable stents: proof of concept (2016)

Stent retrievers can provide long-lasting cerebral vasodilation in patients with delayed cerebral vasospasm.
Track distance runners exhibit bilateral differences in the plantar fascia stiffness (2021)

Abstract Human steady-state locomotion modes are symmetrical, leading to symmetric mechanical function of human feet in general; however, track distance running in a counterclockwise direction exposes the runner’s feet to asymmetrical stress. This may induce asymmetrical adaptation in the runners’ foot arch functions, but this has not been experimentally tested. Here, we show that the plantar fascia (PF), a primary structure of the foot arch elasticity, is stiffer for the left than the right foot as a characteristic of runners, via a cross-sectional study on 10 track distance runners and 10 untrained individuals. Shear wave velocity (index of tissue stiffness: SWV) and thickness of PF and foot dimensions were compared between sides and groups. Runners showed higher PF SWV in their left (9.4 ± 1.0 m/s) than right (8.9 ± 0.9 m/s) feet, whereas untrained individuals showed no bilateral differences (8.5 ± 1.5 m/s and 8.6 ± 1.7 m/s, respectively). Additionally, runners showed higher left to right (L/R) ratio of PF SWV than untrained men (105.1% and 97.7%, respectively). PF thickness and foot dimensions were not significantly different between sides or groups. These results demonstrate stiffer PF in the left feet of runners, which may reflect adaptation to their running-specific training that involves asymmetrical mechanical loading.
A unique application of the sulfide reduction useful for the preparation of isomerically pure aromatic nitro compounds and anilines (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA unique application of the sulfide reduction useful for the preparation of isomerically pure aromatic nitro compounds and anilinesThomas E. NicksonCite this: J. Org. Chem. 1986, 51, 20, 3903–3904Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October 1986https://pubs.acs.org/doi/10.1021/jo00370a031https://doi.org/10.1021/jo00370a031research-articleACS PublicationsRequest reuse permissionsArticle Views740Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparable Worth and the Market Defense: A National Debate (1986)

The concept of comparable worth is rooted in a simple premise: salaries should be based on the intrinsic value of the employee's work to the employer. Yet attempts to enact comparable worth measures have caused controversy in state legislatures, city boardrooms, and courts. Increasingly, the debate has centered on the market's role in setting wages. Comparable worth advocates argue that employers pay women a sex-slanted wage which is illegal under Title VII. Employers, in turn, urge that far from being discriminatory, such wages reflect the market's workings, and are necessary to their survival. The defense has hitherto proven remarkably successful before the courts. Two recent decisions illustrate the ground gained by its advocates. This Comment is an analysis of the two decisions. It focuses on the "market defense" itself by examining its validity in the context of current trends in wage policy. Also included is a discussion of its strategic uses by an actual employer and a look at the "politics" of comparable worth in Washington and the city of San Francisco.
Characterization of Nonspecific Crossover in Split-Flow Thin Channel Fractionation (2008)

Split-flow thin channel (SPLITT) fractionation is a technique for continuous separation of particles or macromolecules in a fluid stream into fractions according to the lateral migration induced by application of a field perpendicular to the direction of flow. Typical applications have involved isolation of different fractions from a polydisperse sample. Some specialized applications involve the separation of the fraction influenced by the transverse field from the fraction that is not. For example, immunomagnetically labeled biological cells may be separated from nonlabeled cells with the application of a transverse magnetic field gradient. In such cases, it may be critically important to minimize contamination of the labeled cells with nonlabeled cells while at the same time maximizing the throughput. Such contamination is known as nonspecific crossover (NSC) and refers to the real or apparent migration of nonmobile particles or cells across stream lines with the mobile material. The possible mechanisms for NSC are discussed, and experimental results interpreted in terms of shear-induced diffusion (SID) caused by viscous interactions between particles in a sheared flow. It is concluded that SID may contribute to NSC, but that further experiments and mathematical modeling are necessary to more fully explore the phenomenon.
Transgenic proteoid roots of white lupin: a vehicle for characterizing and silencing root genes involved in adaptation to P stress (2005)

Summary White lupin ( Lupinus albus L.) has become an illuminating model for the study of plant adaptation to phosphorus (P) deficiency. It adapts to −P stress with a highly coordinated modification of root development and biochemistry resulting in short, densely clustered secondary roots called proteoid (or cluster) roots. In order to characterize genes involved in proteoid root formation and function in a homologous system, we have developed an Agrobacterium rhizogenes ‐based transformation system for white lupin roots that allows rapid analysis of reporter genes as well as RNA interference (RNA i )‐based gene silencing. We used this system to characterize a lupin multidrug and toxin efflux ( Lupinus albus MULTIDRUG AND TOXIN EFFLUX , LaMATE ) gene previously shown to have enhanced expression under −P stress. Here, we show that LaMATE had high expression in proteoid roots not only under −P, but also under −Fe, −N, −Mn and +Al stress. A portion containing the putative LaMATE promoter was fused to GUS and enhanced green fluorescence protein (EGFP) reporter genes, and a translational LaMATE::EGFP fusion was constructed under control of the LaMATE promoter. The LaMATE promoter directed P‐dependent GUS and EGFP expression to proteoid roots. Confocal microscopy in white lupin and Arabidopsis point to the plasma membrane as the likely location of the LaMATE protein. LaMATE displayed homology to FRD3 in Arabidopsis, but did not complement an Arabidopsis ferric reductase defective 3 (FRD3) mutant. RNA i ‐based gene silencing was shown to effectively reduce LaMATE expression in transformed white lupin roots. LaMATE RNAi‐silenced plants displayed an about 20% reduction in dry weight.
p-Azidophenylglyoxal. A heterobifunctional photoactivable cross-linking reagent selective for arginyl residues. (1981)

1. The synthesis described is of p-azidophenylglyoxal (p-APG) by diazotization of p-aminoacetophenone to an intermediate which when reacted with sodium azide gives p-azidoacetophenone; oxidation of the latter with selenium dioxide gives rise to p-APG (corrected melting point, 103-105 degrees C). The phenylglyoxal moiety was designed to react with arginine residues, whereas the p-azidoaryl function generates a reactive nitrene when activated with UV light; p-APG reacts most selectively with arginine and to a lesser extent with cystine and histidine. 2. p-APG has absorption peaks at 205 and 280 nm which decrease on photolysis. 3. Bovine heart lactic dehydrogenase, egg white lysozyme, horse liver alcohol dehydrogenase, and yeast alcohol dehydrogenase, all enzymes having arginyl residues at their active sites, are inhibited by p-APG in the dark. 4. Gel electrophoresis of oligomeric enzymes having arginyl residues at their active sites and exposed to p-APG and to UV irradiation gave varying proportions of monomers and photocross-linked dimers, trimers, tetramers, and larger molecular weight aggregates.
Sound field reproduction around a scatterer in reverberation (2009)

We devise a method for sound field reproduction (SFR) around a solid object in a reverberant room. Until now, work have focussed on reproducing sound in an empty listening space and, for the most part, in non-reverberant environments. However, in a reverberant, room as soon as a listener steps into the space he alters his acoustic environment, generating a sound component which is body-scattered and successively reverberated throughout the room. Building on the model of the sound field around a solid sphere in free space, we extend to reproduction around a human head in a reverberant room. In doing so, we show the relationship between the pressure matching and mode matching approaches of SFR.