gebhart/patrepeval huggingface dataset:
Pyridinate Complexes of Some Metallo-derivatives of Tetraphenylporphine and Tetraphenylchlorin<sup>1</sup> (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyridinate Complexes of Some Metallo-derivatives of Tetraphenylporphine and Tetraphenylchlorin1J. R. Miller and G. D. DoroughCite this: J. Am. Chem. Soc. 1952, 74, 16, 3977–3981Publication Date (Print):August 1, 1952Publication History Published online1 May 2002Published inissue 1 August 1952https://doi.org/10.1021/ja01136a003RIGHTS & PERMISSIONSArticle Views724Altmetric-Citations203LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (507 KB) Get e-Alertsclose Get e-Alerts
Novel Staphylococcal Cassette Chromosome <i>mec</i> Type, Tentatively Designated Type VIII, Harboring Class A <i>mec</i> and Type 4 <i>ccr</i> Gene Complexes in a Canadian Epidemic Strain of Methicillin-Resistant <i>Staphylococcus aureus</i> (2008)

Staphylococcal cassette chromosome mec (SCCmec) is a mobile genetic element characterized by flanking terminal direct and, in most cases, inverted repeat sequences, the mec and ccr gene complexes, and their surrounding DNA regions. Unique combinations of the mec and ccr gene complexes generate various SCCmec types. Six SCCmec types have been reported to date. We describe here a novel SCCmec type identified in a Canadian methicillin-resistant Staphylococcus aureus (MRSA) epidemic strain. MRSA clinical isolates were screened for known SCCmec types by multiplex and conventional PCR methods. Three phenotypically and genotypically identical MRSA clinical isolates with a pulsotype identical to CMRSA9 were identified locally and found to be nontypeable by available SCCmec typing schemes. Complete sequencing of the SCCmec element revealed a nucleotide fragment of 32,168 bp integrated at an identical chromosomal integration site (attBscc) at the 3' end of the orfX gene. The nucleotide sequences at the chromosome-SCCmec junction regions were typical of other SCCmec types, but the element harbored a unique combination of class A mec and type 4 ccr gene complexes. Sequence recombination analysis suggested that this unique SCCmec type may be derived from homologous recombination between the previously described SCC(RP62A) of S. epidermidis strain RP62A and SCC composite island of S. epidermidis ATCC 12228, respectively, or via recombination of other staphylococcal strains that carry the same or similar mobile cassettes. We identified a previously undescribed type of SCCmec from isolate C10682, tentatively designated type VIII, and we provide compelling evidence supporting the ability of SCC elements to transfer horizontally or undergo recombination to generate new SCCmec types.
Data structures for weighted matching and nearest common ancestors with linking (1990)

This paper shows that the weighted matching problem on general graphs can be solved in time O(n(m + n log n)), f or n and m the number of vertices and edges, respectively. This was previously known only for bipartite graphs. It also shows that a sequence of m nca and link operations on n nodes can be processed on-line in time O(ma(m, n)+n). This was previously known only for a restricted type of link operation.
Defining the Mechanism of Activation of AMP-activated Protein Kinase by the Small Molecule A-769662, a Member of the Thienopyridone Family (2007)

AMP-activated protein kinase (AMPK) plays a key role in maintaining energy homeostasis. Activation of AMPK in peripheral tissues has been shown to alleviate the symptoms of metabolic diseases, such as type 2 diabetes, and consequently AMPK is a target for treatment of these diseases. Recently, a small molecule activator (A-769662) of AMPK was identified that had beneficial effects on metabolism in ob/ob mice. Here we show that A-769662 activates AMPK both allosterically and by inhibiting dephosphorylation of AMPK on Thr-172, similar to the effects of AMP. A-769662 activates AMPK harboring a mutation in the gamma subunit that abolishes activation by AMP. An AMPK complex lacking the glycogen binding domain of the beta subunit abolishes the allosteric effect of A-769662 but not the allosteric activation by AMP. Moreover, mutation of serine 108 to alanine, an autophosphorylation site within the glycogen binding domain of the beta1 subunit, almost completely abolishes activation of AMPK by A-769662 in cells and in vitro, while only partially reducing activation by AMP. Based on our results we propose a model for activation of AMPK by A-769662. Importantly, this model may provide clues for understanding the mechanism by which AMP leads to activation of AMPK, which in turn may help in the identification of other AMPK activators.
Medical and surgical management of nasal polyps (2001)

Sinonasal polyposis represents a chronic inflammatory condition of unknown etiology. It is often associated with systemic diseases and is characterized by nasal obstruction, reduction in sense of smell, infection, and impaired quality of life. Endoscopy has enhanced the diagnosis and management of nasal polyps. The initial approach is medical management. Medical therapy consists of administration of intranasal steroids or a short course of systemic steroids. Other medical treatments considered are use of antibiotics, leukotriene modifiers, and acetylsalicylic acid avoidance. Surgical removal is performed for nonresponders to medical management. The purpose of surgery is to restore the nasal physiology by making the nose free from nasal polyps and allowing drainage of infected sinuses. With a computer-assisted navigation system and power instrumentation, surgical removal of polyps can be done more easily and accurately with fewer complications than previously. Medical therapy after surgery is essential for preventing recurrence.
Statistic IP Network Quality's Fuzzy Evaluation Method (2010)

The definition of network quality was presented and its connotation was expatiated for scientific evaluating network running status.The metrics were designed to reflect the network quality and the membership vector was used to compute its statistic values,the values can definitely reflect the metrics'ranks in the period of statistics.The network quality fuzzy evaluation model based on statistics was designed.The case study evaluated the four local IP networks' qualities based on their statistic values and got the quantitive evaluating results.
Growth of Plant Root Cultures in Liquid‐ and Gas‐Dispersed Reactor Environments (1993)

The growth of Agrobacterium transformed "hairy root" cultures of Hyoscyamus muticus was examined in various liquid- and gas-dispersed bioreactor configurations. Reactor runs were replicated to provide statistical comparisons of nutrient availability on culture performance. Accumulated tissue mass in submerged air-sparged reactors was 31% of gyratory shake-flask controls. Experiments demonstrate that poor performance of sparged reactors is not due to bubble shear damage, carbon dioxide stripping, settling, or flotation of roots. Impaired oxygen transfer due to channeling and stagnation of the liquid phase are the apparent causes of poor growth. Roots grown on a medium-perfused inclined plane grew at 48% of gyratory controls. This demonstrates the ability of cultures to partially compensate for poor liquid distribution through vascular transport of nutrients. A reactor configuration in which the medium is sprayed over the roots and permitted to drain down through the root tissue was able to provide growth rates which are statistically indistinguishable (95% T-test) from gyratory shake-flask controls. In this type of spray/trickle-bed configuration, it is shown that distribution of the roots becomes a key factor in controlling the rate of growth. Implications of these results regarding design and scale-up of bioreactors to produce fine chemicals from root cultures are discussed.
Synthesis and aldose reductase inhibitory activity of thiazolidinecarboxylic acids containing a disulfide bond. (1985)

Symmetrical disulfides (2a-m, 9, 13) were synthesized by oxidation or by a new reaction using ethyl α-bromomalonate from the corresponding thiazolidinecarboxylic acids containing a sulfhydryl group (1a-m, 8, 12). Mixed disulfides (14a-g) were synthesized by reaction of thiols (1a, c) with Bunte salt. Stereoselective acylation of the thiazolidinecarboxylic acid 5a gave the symmetrical disulfide 2c or the dicarboxylic acid 15, depending on the conditions. The absolute configurations of these disulfides were decided to be (2R, 2'R, 4R, 4'R) by comparison of nuclear magnetic resonance spectra and specific rotation with those of the (2S, 2'S, 4R, 4'R)-disulfide (4). The disulfides were tested for aldose reductase inhibitory activity in vitro. The symmetrical disulfide 2j and dicarboxylic acid 15 showed remarkably high potency.
Cloning and Sequence Analysis of cDNA for<i>Irpex lacteus</i>Aspartic Proteinase (1989)

Journal Article Cloning and Sequence Analysis of cDNA for Irpex lacteus Aspartic Proteinase Get access Hideyuki Kobayashi, Hideyuki Kobayashi Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Satoshi Sekibata, Satoshi Sekibata Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Shibuya, Hiroshi Shibuya Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Shigeki Yoshida, Shigeki Yoshida Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Isao Kusakabe, Isao Kusakabe Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Kazuo Murakami Kazuo Murakami Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 53, Issue 7, 1 July 1989, Pages 1927–1933, https://doi.org/10.1080/00021369.1989.10869568 Published: 01 July 1989 Article history Received: 31 January 1989 Published: 01 July 1989
Forward and backward motion control of Personal riding-type wheeled Mobile Platform (2004)

We propose a new concept in personal vehicles called the 'Personal riding-type wheeled Mobile Platform (PMP)' consisting of two wheels and a standing base for a human. The two wheels are driven independently, and traveling and steering is achieved by simply changing the relative position of the rider's center of gravity (COG) on the base. The vehicle has two merits: reducing the total weight of the simple structure and saving space by not using a steering unit. In this paper, the mechanism of the first prototype, PMP-1, is introduced and its posture stabilizing and running control methods are proposed. The effectiveness of the posture stabilization control methods is demonstrated in computer simulations and human riding experiments. In the running control method, maneuverability by movement of the rider's COG is also investigated experimentally. The results demonstrate that the posture of the rider can be maintained and the velocity of forward and backward traveling can be controlled according to the rider's intentions.
Withanolides-Induced Breast Cancer Cell Death Is Correlated with Their Ability to Inhibit Heat Protein 90 (2012)

Withanolides are a large group of steroidal lactones found in Solanaceae plants that exhibit potential anticancer activities. We have previously demonstrated that a withanolide, tubocapsenolide A, induced cycle arrest and apoptosis in human breast cancer cells, which was associated with the inhibition of heat shock protein 90 (Hsp90). To investigate whether other withanolides are also capable of inhibiting Hsp90 and to analyze the structure-activity relationships, nine withanolides with different structural properties were tested in human breast cancer cells MDA-MB-231 and MCF-7 in the present study. Our data show that the 2,3-unsaturated double bond-containing withanolides inhibited Hsp90 function, as evidenced by selective depletion of Hsp90 client proteins and induction of Hsp70. The inhibitory effect of the withanolides on Hsp90 chaperone activity was further confirmed using in vivo heat shock luciferase activity recovery assays. Importantly, Hsp90 inhibition by the withanolides was correlated with their ability to induce cancer cell death. In addition, the withanolides reduced constitutive NF-κB activation by depleting IκB kinase complex (IKK) through inhibition of Hsp90. In estrogen receptor (ER)-positive MCF-7 cells, the withanolides also reduced the expression of ER, and this may be partly due to Hsp90 inhibition. Taken together, our results suggest that Hsp90 inhibition is a general feature of cytotoxic withanolides and plays an important role in their anticancer activity.
Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis (2016)

Our data define an unconventional CD8(+) T-cell subset (polycytotoxic T cells) that is based on antigen recognition and function. The results link clinical and mechanistic evidence that glycolipid-responsive, polycytotoxic T cells contribute to protection against tuberculosis.
Designing an Agent for Information Extraction from Persian E-shops (2018)

E-shops are among the most conventional applications of Electronic Commerce. In these shops, the buyers search for their goods through key words or classifications and read the product description provided by the sellers. Though, when the number of items is high, this gets to be difficult for the users. On the one hand, there are too many e-shops, and browsing in these shops to find the best and most appropriate goods is a difficult and time-consuming process. On the other hand, product descriptions are not the same in different websites, and there are different product forms. This study investigates about products and sellers in various websites based on the conditions and user requirements through software agents which present the extracted information in the form of a table to the users which enables them to compare prices and each seller’s conditions without spending too much time for browsing. Using this method increases precision and recall indices comparing to a conventional user browsing.
Greed and the Market (2009)

In the 1987 Oliver Stone-directed movie Wall Street, Michael Douglas portrays Gordon Gekko, a 'corporate raider' who specialises in taking-over firms and then asset-stripping them. In one of the film's most memorable scenes, Gekko attempts to persuade a meeting of shareholders to sell out to him with the promise of large financial rewards. Gekko encourages the shareholders to think only of their own pecuniary gain, to act on the basis of personal greed: The point is, ladies and gentleman, that greed — for lack of a better word — is good. Greed is right. Greed works. Greed clarifies, cuts through, and captures the essence of the evolutionary spirit. Greed, in all of its forms — greed for life, for money, for love, knowledge — has marked the upward surge of mankind. KeywordsSocial CapitalMarket PriceMarket EconomyEconomic FreedomEconomic AffairThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Water-dispersible magnetite-graphene-LDH composites for efficient arsenate removal (2011)

A composite material, containing magnetite particles, graphene and layered double hydroxides (LDHs) was fabricated through a simple two-step reaction. Graphene was used as the matrix for supporting magnetite particles and LDH nanoplates. The synthesized magnetite-graphene-LDH (MGL) composites were characterized by field emission scanning electron microscopic (FE-SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transformed infrared (FTIR) spectroscopy, N2adsorption-desorption, and X-ray photoelectron spectroscopy (XPS). The MGL composites were applied to remove arsenate from aqueous solutions and could be easily separated by magnetic separation process. The results showed enhanced adsorption capacity of arsenate on the MGL as compared to that of pure Mg/Al LDHs. The surface area of MGL is greatly enhanced through the incorporation of magnetite particles and graphene, which provides more active sites for arsenate uptake. Moreover, LDHs were hybridized with mechanically and chemically stable graphene materials, providing an accessible diffusion pathway in the macropore domain, and therefore their adsorption capacity was enhanced. The fast and efficient adsorption of arsenate from solution to MGL suggests that the MGL composites are potential and suitable materials in the preconcentration of arsenate from large volumes of aqueous solutions in wastewater treatment.
An algorithm for UWB radar-based human detection (2009)

This paper presents an algorithm for human presence detection in urban environments using an ultra-wide-band (UWB) impulse-based mono-static radar. A specular multi-path model (SMPM) is used to characterize human body scattered UWB waveforms. The SMPM parameters are used within a classical likelihood ratio detector framework to detect the presence of humans via gait, with the aid of a multi-target tracking technique (MTT). Experimental results on a simple human gait detection problem in an outdoor urban environment are presented to illustrate and validate the approach.
ULTRASTRUCTURAL STUDIES OF THE DYING-BACK PROCESS (1974)

The spatio-temporal pattern of distal peripheral nerve, sensory and motor nerve terminal, degeneration in experimental acrylamide neuropathy has been examined. Tissue was sampled from limbs of cats throughout various stages of intoxication (e.g. 7–32 days of 10 mg/kg/day and up to 294 days of 3 mg/kg/day of acrylamide) and examined by light and electron microscopy. Nerve terminals of a few Pacinian corpuscles in hindfoot and forefoot toepads displayed the first abnormalities, before the onset of clinical signs; filopod axon processes were lost, axolemmas disappeared and axoplasm was phagocytosed by inner core cells. Degeneration of adjacent primary annulospiral endings of muscle spindles in hindfoot muscle began shortly after the first changes in Pacinian corpuscle axons. Later, juxtaposed secondary muscle spindle endings and motor nerve terminals, supplying nearby extrafusal muscle fibers, began to degenerate. These sensory and motor nerve terminals accumulated neurofilaments, became swollen and disappeared. Contemporaneous with the early degenerative changes in some nerve terminals, seattered preterminal nodes, and their paranodes, displayed focal axonal accumulations of neurofilaments, mitochondria and dense bodies. These organelle conglomerations were associated with focal axonal swelling and paranodal retraction of myelin. This axonal change appeared to spread along internodes and to lead to fiber degeneration with the formation of ovoids which were later replaced by bands of Büngner. Fiber degeneration proceeded proximally as intoxication progressed. Above the proximal limit of fiber breakdown, axons displayed progressively fewer abnormalities in the form of adaxonal Schwann cell ingrowths and swollen paranodal regions. The cardinal conclusions of this study of acrylamide neuropathy are: 1-some distal sensory nerve endings (Pacinian corpuscle and annulospiral terminals) in the hindfeet begin to degenerate before adjacent motor nerve terminals supplying extrafusal muscles, and 2− the distal tips of the largest and longest axons are not most vulnerable, although there is a propensity for long and large axons to die-back first. In view of these observations, the etiology of the dying-back process requires re-examination.
Beneficial and detrimental role of adenosine signaling in diseases and therapy (2015)

Adenosine is a major signaling nucleoside that orchestrates cellular and tissue adaptation under energy depletion and ischemic/hypoxic conditions by activation of four G protein-coupled receptors (GPCR). The regulation and generation of extracellular adenosine in response to stress are critical in tissue protection. Both mouse and human studies reported that extracellular adenosine signaling plays a beneficial role during acute states. However, prolonged excess extracellular adenosine is detrimental and contributes to the development and progression of various chronic diseases. In recent years, substantial progress has been made to understand the role of adenosine signaling in different conditions and to clarify its significance during the course of disease progression in various organs. These efforts have and will identify potential therapeutic possibilities for protection of tissue injury at acute stage by upregulation of adenosine signaling or attenuation of chronic disease progression by downregulation of adenosine signaling. This review is to summarize current progress and the importance of adenosine signaling in different disease stages and its potential therapeutic effects.
Performance & Energy Tradeoffs for Dependent Distributed Applications Under System-wide Power Caps (2018)

Large scale parallel machines are subject to system-wide power budgets (or caps). As these machines grow in capacity, they can concurrently execute dependent applications that were previously processed serially. Such application coupling saves IO and time as the applications now communicate at runtime instead of through disk. Such coupled applications are predicted to be a major workload for future exascale supercomputers; e.g., scientific simulations will execute concurrently with in situ analysis. While support for system-wide power caps has been widely studied, prior work does not consider the impact on coupled applications.