gebhart/patrepeval huggingface dataset:
Bone marrow and serum connective tissue polypeptides in idiopathic myelofibrosis (2008)

The distribution of collagen type VI and tenascin has been determined in both normal and myelofibrotic bone marrow by immunohistological techniques. In normal sections positivity was demonstrated in the periosteum (collagen type VI and tenascin) and in the walls of small blood vessels (tenascin). In contrast, myelofibrotic bone marrow showed an increased deposition of both proteins, especially collagen type VI, although this increase was restricted to the later fibrotic stages of the disease. Serum concentrations of collagen type I (PICP), collagen type III (PIIIP) and laminin (laminin P1) related polypeptides were determined in a further 26 patients. PIIIP levels were significantly raised, in contrast to PICP and laminin P1 concentrations. All three markers, however, were significantly elevated in patients with active/transforming disease. Laminin P1 and PICP levels showed a strong correlation, indicating a relationship between basement membrane and interstitial collagen metabolism, although they do not appear to offer any advantage over PIIIP for the monitoring of disease activity.
A New Emergency Cricothyroidotomy Instrument (1983)

Cricothyroidotomy is an excellent emergency procedure for airway obstruction which cannot be relieved by oral or nasal intubation. Important factors for a device for emergency cricothyroidotomy include selective airways, an airway lumen of sufficient size to permit suctioning or adequate airflow during spontaneous breathing, and the ability to assess depth and angle of penetration. An instrument that is simple to insert, offers protection against overpenetration, minimizes bleeding, and provides an airway offering a variety of lumens is described. It appears to provide an ideal means of accomplishing an emergency cricothyroidotomy for airway obstruction.
Integrating Knowledge-based and Collaborative-filtering Recommender Systems (2000)

Knowledge-based and collaborative-filtering recommender systems facilitate electronic commerce by helping users find appropriate products from large catalogs. This paper discusses the strengths and weaknesses of both techniques and introduces the possibility of a hybrid recommender system that combines the two approaches. An approach is suggested in which knowledge-based techniques are used to bootstrap the collaborative filtering engine while its data pool is small, and the collaborative filter is used as a postfilter for the knowledge-based recommender. Collaborative Filtering Collaborative filtering recommender system are a widelyaccepted technique in electronic commerce. (See [Resnick &amp; Varian, 1997] and other articles in that special issue. A recent survey is found in [Maes, Guttman &amp; Moukas, 1999]. See also [Goldberg et al. 1992] and [Resnick, et al. 1994].) These systems aggregate data about customers&apos; purchasing habits or preferences and make recommendations to other...
On the Reliability of Profile Matching Across Large Online Social Networks (2015)

Matching the profiles of a user across multiple online social networks brings opportunities for new services and applications as well as new insights on user online behavior, yet it raises serious privacy concerns. Prior literature has showed that it is possible to accurately match profiles, but their evaluation focused only on sampled datasets. In this paper, we study the extent to which we can reliably match profiles in practice, across real-world social networks, by exploiting public attributes, i.e., information users publicly provide about themselves. Today's social networks have hundreds of millions of users, which brings completely new challenges as a reliable matching scheme must identify the correct matching profile out of the millions of possible profiles. We first define a set of properties for profile attributes--Availability, Consistency, non-Impersonability, and Discriminability (ACID)--that are both necessary and sufficient to determine the reliability of a matching scheme. Using these properties, we propose a method to evaluate the accuracy of matching schemes in real practical cases. Our results show that the accuracy in practice is significantly lower than the one reported in prior literature. When considering entire social networks, there is a non-negligible number of profiles that belong to different users but have similar attributes, which leads to many false matches. Our paper sheds light on the limits of matching profiles in the real world and illustrates the correct methodology to evaluate matching schemes in realistic scenarios.
Risk Factors for IgA Nephropathy: A Case-Control Study with Incident Cases in Japan (2001)

Our findings imply that some genetic factors, immune response to infections in the upper respiratory tract and nutritional imbalance would promote the development of IgAN.
A comprehensive method for multilingual video text detection, localization, and extraction (2005)

Text in video is a very compact and accurate clue for video indexing and summarization. Most video text detection and extraction methods hold assumptions on text color, background contrast, and font style. Moreover, few methods can handle multilingual text well since different languages may have quite different appearances. This paper performs a detailed analysis of multilingual text characteristics, including English and Chinese. Based on the analysis, we propose a comprehensive, efficient video text detection, localization, and extraction method, which emphasizes the multilingual capability over the whole processing. The proposed method is also robust to various background complexities and text appearances. The text detection is carried out by edge detection, local thresholding, and hysteresis edge recovery. The coarse-to-fine localization scheme is then performed to identify text regions accurately. The text extraction consists of adaptive thresholding, dam point labeling, and inward filling. Experimental results on a large number of video images and comparisons with other methods are reported in detail.
A new locus for autosomal dominant retinitis pigmentosa on the short arm of chromosome 17 (1994)

Retinitis pigmentosa (RP) is a group of genetically and clinically heterogeneous retinopathies, some of which have been shown to result from mutations in two different known retinal genes, rhodopsin (3q) and peripherin-rds (6p). Three additional anonymous loci at 7p, 7q and pericentric 8 have been implicated by linkage studies. There are still, however, a few families in which all known loci have been excluded. In this report we present data indicating a location, on the short arm of chromosome 17, for the autosomal dominant RP (ADRP) locus in a large South African (SA) family of British ancestry. Positive two-point lod scores have been obtained for nine markers (D17S938, Z = 5.43; D17S796, Z = 4.82; D17S849, Z = 3.6; D17S786, Z = 3.55; TP53, Z = 3.55; D17S578, Z = 3.29; D17S960, Z = 3.16; D17S926, Z = 1.51; D17S804, Z = 0.47 all at theta = 0.10 except D17S804 and D17S926, theta = 0.20). These data provide definitive evidence for the localization of an ADRP gene on chromosome 17p. The human recoverin gene has been localized to 17p13.1 and was consequently a prime candidate for ADRP in the family studied. However, mutation screening of the three exons of this gene failed to produce any evidence of recoverin being the gene involved in the pathogenesis of ADRP in this SA family.
The tyrphostin AG1024 accelerates the degradation of phosphorylated forms of retinoblastoma protein (pRb) and restores pRb tumor suppressive function in melanoma cells. (2003)

Constitutive cell surface receptor kinase signaling and persistent phosphorylation/inactivation of the retinoblastoma (pRb) family of proteins (pRb, p107 and p130, known as pocket proteins) have been implicated in conferring uncontrolled growth to melanoma cells. However, the signals linking receptor kinase activity to neutralization of pocket proteins have not yet been fully elucidated. We therefore used specific chemical inhibitors to examine pRb regulation in melanoma cells. The most efficient agent, AG1024, known as an inhibitor of insulin-like growth factor 1 receptor and insulin receptor, arrested melanoma cell growth in vitro at nanomolar concentrations within 24 h of application. AG1024 inhibited the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and restored pRb tumor suppressive function. The latter was observed by the reduction in the phosphorylated forms of pRb, p107 and p130, and the formation of growth suppressive DNA binding complexes consisting of pRb and E2F1 or E2F3. The loss of phosphorylated forms of pRb at early time points after AG1024 application was not associated with suppression of cyclin-dependent kinases 2 and 4 activity but rather with proteasomal and nonproteasomal degradation. Thus, inhibition of melanoma cell proliferation by AG1024 is mediated by inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase 2 signaling and activation of pRb by a mechanism involving protein degradation.
A Novel Anisotropic Conductive Adhesive for Lead-Free Surface Mount Electronics Packaging (2006)

Abstract The electronics industry, in recent years, has been focusing primarily on product miniaturization and lead-free assembly. The need for product miniaturization is due to the continuous demand for portable electronic products that are multifunctional, yet smaller, faster, cheaper, and lighter. This is forcing the industry to design and assemble products with miniature passive and active devices. These devices typically have fine pitch footprints that provide a very small surface area for attachment. The solder attach technique relies primarily on the formation of intermetallics between the mating metallic surfaces. With a reduction in the surface area of the pads, the ratio of intermetallic to solder is very high once the solder joint is formed. This could result in unreliable solder joints, due to the brittle nature of intermetallics. In addition, the need to eliminate lead-based materials as a means of interconnection has renewed the industry’s interest in exploring other means of assembling surface mount devices reliably. The use of a novel anisotropic conductive adhesive (ACA) as a means for assembling surface mount devices, the ACA’s performance characteristics, and preliminary research findings are discussed in this paper. Typically, ACAs require the application of pressure during the curing process to establish the electrical connection. The novel ACA uses a magnetic field to align the particles in the Z-axis direction and eliminates the need for pressure during curing. The formation of conductive columns within the polymer matrix provides a very high insulation resistance between adjacent conductors. The novel ACA also enables mass curing of the adhesive, eliminating the need for sequential assembly. The novel ACA was found to be very effective in providing the interconnection for surface mount technology (SMT) passives and leaded, bumped, or bumpless integrated circuit packages. The requirement for precise stencil printing was eliminated, as the application of magnetic field aligned the conductive columns in the Z-axis direction eliminating any lateral conductivity. The ability to mass cure the adhesive while applying the magnetic field reduced the assembly time considerably. Placement accuracy was still found to be very critical. Shear testing of adhesive joints after thermal aging showed significance past 500 h and after temperature–humidity aging showed significance within the first 100 h. I–V characteristics of the daisy chained ball grid array devices assembled with and without bumps revealed considerable difference in the breakdown current. The correlation between initial contact resistance of the daisy chain and the final breakdown current was also determined. Preliminary experiments and findings, discussed in this paper, show the viability of the ACA for mixed SMT assembly. Further experimentations will include in situ contact resistance measurements during thermal aging, temperature–humidity aging, drop testing and thermal shock.
Effective Work Function Modulation by Aluminum Ion Implantation on Hf-Based High- $k$/Metal Gate pMOSFET (2010)

The impact of aluminum (Al) implantation into TiN/HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> / SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> on the effective work function is investigated. Al implanted through poly-Si cannot attain sufficient flatband voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">FB</sub> ) shift unless at higher implantation energy. Al implanted through TiN at 1.2 keV with a dose of 5 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">15</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> raised the V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">FB</sub> to about 250 mV compared with a nonimplanted gate stack. Moreover, the V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">FB</sub> shift can be up to about 800 mV at 2 keV with the same dose level accompanied with slightly equivalent oxide thickness penalty and gate leakage current degradation. Optimized process window to control Al diffusion depth was essential to minimize these impacts.
Interferometric Surface Roughness Measurement (1969)

This paper reports a method of measuring surface roughness using coherent optics and interferometry. Included are both the theory of the technique and experimental verification. The range of surface roughness which can be accurately measured by this method is also reported.
Nonparametric Inference for a Family of Counting Processes (1978)

Let $\mathbf{B} = (N_1, \cdots, N_k)$ be a multivariate counting process and let $\mathscr{F}_t$ be the collection of all events observed on the time interval $\lbrack 0, t\rbrack.$ The intensity process is given by $\Lambda_i(t) = \lim_{h \downarrow 0} \frac{1}{h}E(N_i(t + h) - N_i(t) \mid \mathscr{F}_t)\quad i = 1, \cdots, k.$ We give an application of the recently developed martingale-based approach to the study of $\mathbf{N}$ via $\mathbf{\Lambda}.$ A statistical model is defined by letting $\Lambda_i(t) = \alpha_i(t)Y_i(t), i = 1, \cdots, k,$ where $\mathbf{\alpha} = (\alpha_1, \cdots, \alpha_k)$ is an unknown nonnegative function while $\mathbf{Y} = (Y_1, \cdots, Y_k),$ together with $\mathbf{N},$ is a process observable over a certain time interval. Special cases are time-continuous Markov chains on finite state spaces, birth and death processes and models for survival analysis with censored data. The model is termed nonparametric when $\mathbf{\alpha}$ is allowed to vary arbitrarily except for regularity conditions. The existence of complete and sufficient statistics for this model is studied. An empirical process estimating $\beta_i(t) = \int^t_0 \alpha_i(s) ds$ is given and studied by means of the theory of stochastic integrals. This empirical process is intended for plotting purposes and it generalizes the empirical cumulative hazard rate from survival analysis and is related to the product limit estimator. Consistency and weak convergence results are given. Tests for comparison of two counting processes, generalizing the two sample rank tests, are defined and studied. Finally, an application to a set of biological data is given.
Transmission of multiple description and layered video over an EGPRS wireless network (2000)

We investigate the ability of multiple descriptions (MD) and layered coding to improve the quality of video transmitted over EGPRS networks. One-layer video sent over a single channel on such a network has a fairly sharp quality transition, depending on a user's location. Either the video can be transmitted reliably (if the video rate is less than or equal to what the channel can sustain), or it is subjected to many lost packets. In this system, MD and layered video may offer two ways to improve the video quality beyond that of the one-layer video. First, each sub-stream can be sent on a separate channel, essentially doubling the assigned bandwidth and increasing the video quality. Second, MD and layered video are more error resilient than one-layer video, potentially improving the video quality seen by users in poor locations. We find that for the system scenarios considered, one and two-layer coding outperform MD coding, depending upon the number of wireless channels used for the video transport.
A prediction model of thrust force for drilling of bidirectional carbon fiber–reinforced carbon matrix composites (2020)

Carbon fiber-reinforced carbon matrix composites have been widely used for the manufacturing of thermostructural parts for several industries such as the aerospace and automotive. Drilling is an extremely common method used in the machining of carbon fiber-reinforced carbon matrix composites before assembly. However, their non-homogeneous, anisotropic, and brittle nature make difficult to guarantee the hole quality in drilling. Some severe drilling defects, such as burrs, delamination, and tear, usually occur. In this regard, it is necessary to accurately predict the thrust force in drilling of carbon fiber-reinforced carbon matrix composites. Therefore, in this article, based on the cutting theory of fiber-reinforced polymer composites, an alternative thrust force prediction model for drilling of bidirectional carbon fiber-reinforced carbon matrix composites is proposed. The cutting force of the cutting lips is established by dividing the cutting deformation zone into three regions according to the machined material structure based on the Zhang's model in cutting of fiber-reinforced polymer. The periodic variation of fiber orientation is considered in detail. The experimental results show that the relative deviations of the predicted and experimental values of the thrust force are less than 14.36%.
C3a-derived peptide binds to the type I Fc R and inhibits proximal-coupling signal processes and cytokine secretion by mast cells (2008)

A peptide with the natural sequence derived from the complement component C3a, designated C3a7, and C3a9, having a modified sequence of that, was previously shown to inhibit the high-affinity IgER (FcepsilonRI)-induced secretory response of both mucosal and serosal-type mast cells. In addition, several processes that couple the FcepsilonRI stimulus to the cellular response were all suppressed in the presence of these peptides. Here, we show that peptide C3a9 binds to the FcepsilonRI on the surface of unperturbed mast cells (rat mucosal-type RBL-2H3 cell line) and remains bound even after FcepsilonRI-IgE aggregation by antigen as assessed by confocal microscopy. Moreover, that peptide interferes the initial steps of FcepsilonRI-coupling network. Namely, peptide binding to the FcepsilonRI beta-chain interrupts this chain's association with both src family protein tyrosine kinases Lyn and Fyn and enhances the internalization of the receptor. C3a9 was further found to inhibit the phosphorylation of two members of the mitogen-activated protein kinase family, extracellular signal-regulated kinase (ERK) and p38. Although ERK is usually activated via the ras-raf-mitogen-activated protein kinase/ERK kinase (MEK) pathway, our results show that C3a9 has no effect on the c-raf phosphorylation, suggesting that this complement-derived peptide inhibits ERK activation via an alternative route. C3a9 also inhibits the late-phase response to FcepsilonRI stimulus of bone marrow-derived mast cells, reducing secretion of the inflammatory cytokines IL-6 and tumor necrosis factor-alpha. Taken together, the consequence of its interference with the earliest steps of FcepsilonRI stimulus-response coupling and the C3a-derived peptide inhibits both the immediate and the late-phase responses of mast cells.
Similarity Forests (2017)

Random forests are among the most successful methods used in data mining because of their extraordinary accuracy and effectiveness. However, their use is primarily limited to multidimensional data because they sample features from the original data set. In this paper, we propose a method for extending random forests to work with any arbitrary set of data objects, as long as similarities can be computed among the data objects. Furthermore, since it is understood that similarity computation between all O(n2) pairs of n objects might be expensive, our method computes only a very small fraction of the O(n2) pairwise similarities between objects to construct the forests. Our results show that the proposed similarity forest approach is very efficient and accurate on a wide variety of data sets. Therefore, this paper significantly extends the applicability of random forest methods to arbitrary data domains. Furthermore, the approach even outperforms traditional random forests on multidimensional data. We show that similarity forests are robust to the noisy similarity values that are ubiquitous in real-world applications. In many practical settings, the similarity values between objects are incompletely specified because of the difficulty in collecting such values. Similarity forests can be used in such cases with straightforward modifications.
Highly Dense, Transparent α‐ <scp> <scp>Al</scp> </scp> <sub>2</sub> <scp> <scp>O</scp> </scp> <sub>3</sub> Ceramics From Ultrafine Nanoparticles Via a Standard <scp>SPS</scp> Sintering (2013)

Using discrete, ultrafine alumina, highly dense transparent (71% real in‐line transmission, RIT , λ = 640 nm) ceramics were achieved with grain size as small as 260 nm using standard SPS sintering. We show that use of La 3+ as a dopant greatly reduces sensitivity to the sintering temperatures. Transparent alumina were achieved in a large range of sintering temperatures, 1140°C < T < 1200°C, thus providing better reliability and flexibility into the fabrication of large sintered transparent ceramic bodies.
An Intelligent Car Park Management System : Hierarchical Placement Algorithm Based on Nearest Location (2018)

Finding a parking spot can become quite stressful especially for the cases where the final destination of the journey is not well known and the parking region is rather complicated with large numbers of spots. Identification of a suitable parking spot can also be considered as an expensive process since it often causes an increase of vehicle traffic which in turn causes a consequent increase of pollution. In this paper, we present a hierarchical approach that helps users to reach a free parking spot easily, in a small area or a city. This solution introduces an approach which makes searching process in car parking applications efficient in terms of time and energy. It introduces two levels of hierarchy to make placement process more efficient. In the first level, algorithm only checks for the nearest car park. At the second level, algorithm focuses on the car park that is the nearest and checks the nearest parking spot in that car park. Using this hierarchical approach, search for an empty spot becomes more time efficient. Simulation results are presented in this study to show the efficiency of the proposed hierarchical approach. Both hierarchical and non-hierarchical approaches are employed for the same scenario in order to show the effectiveness of the new approach. According to simulation results, hierarchical approach is more efficient in terms of search time and energy. Briefly, we investigate how hierarchical approach affects the search algorithms used for car parking applications.