gebhart/patrepeval huggingface dataset:
Quantitative Grading of Tissue and Nuclei in Prostate Cancer for Prognosis Prediction (1997)

rostate cancer is evidenced by profound histological, cellular, and nuclear changes in the organization of the prostate. Histological assessment of prostate tissue taken from surgically removed tumors has traditionally relied on visual pathological interpretation. The principal classification scheme used in visual pathology of the prostate, Gleason grading, has proven successful in characterizing the state of disease but has had limited prognostic value. We are conducting studies that aim to provide quantitative measures of disease state to improve prognosis prediction. Our findings show that the orientational distribution of tumor cells, often assumed to be isotropic, can play a significant role in statistical studies of intranuclear DNA organization. Inclusion of anatomical factors in the selection of reference frames for measurements of intranuclear DNA can improve the statistical power of cytometric studies and may provide a unifying framework for relating histological, morphometric, and intranuclear descriptions of prostate tumors. (
Context-aware communication services a framework for building enhanced IP telephony services (2005)

Communication is an essential part of our daily life. A multitude of devices enable users to communicate everywhere and anytime. One drawback resulting from this ability is the expectation of a caller to always reach the callee. As a consequence the possibility to restrict "availability for communication" becomes a necessary feature too. Users demand efficient filtering mechanisms to control incoming calls according to their current context. Communication services should become more user centric and consider context information to adapt to the most suitable behavior. This paper investigates the use of context information to enhance existing SIP call control services and services created with the call processing language (CPL). These context-aware communication services are the proposed approach to cope with the demand for a user centric control of incoming calls. The proposed solutions have been implemented as an extended SIP call control service and an extension to the existing CPL syntax. Currently, location information forms the primary source of context information. Different indoor location sensing systems have been evaluated. Finally, two different kinds of service types have been chosen for evaluation as representatives for the variety of service creation approaches especially in a SIP environment.
Enhancing Mobile Content Privacy with Proxemics Aware Notifications and Protection (2016)

Given the widespread adoption of mobile devices and the private personal and work information they carry, casual or deliberate shoulder surfing is an increasing concern with these devices. We iteratively designed a tablet interface that detects when people nearby are looking at the screen, providing awareness through glyph notifications, and response through visual protections, and evaluated its use in two experiments. The results indicate that mobile content privacy management systems such as ours could help alleviate the cognitive and social burden of managing mobile device privacy in dynamic settings. We identify physical privacy behaviours and preferences that can inform the design of privacy notification and management protocols on mobile devices. We argue that such systems require subtlety so as not to advertise the users' intention for privacy, flexibility in addressing dynamic privacy needs and trustworthiness to promote adoption.
Über das Verhalten löslicher Polyelektrolyte gegenüber Ionenaustauschern (1950)

Abstract Ionenaustausch kann mit Ionen, die im Verhältnis zur Maschenweite des Austauschers zu gross sind, nicht stattfinden. Diese Erscheinung kann zur raschen Ionentrennung verwendet werden. Die selektive Adsorption aus polymerhomologen Elektrolytgemischen wird in Abhängigkeit von der Ionengrösse und vom Quellungsgrad des Ionenaustauschers diskutiert.
High intensity regimens with autologous hematopoietic stem cell transplantation as treatment of multiple myeloma. (2002)

The treatment of multiple myeloma still remains under investigation. Conventional chemotherapy with currently used agents (i.e., Melphalan) effects complete remission in no more than 5% of patients. High dose chemotherapy followed by hematopoietic stem cells transplantation results in complete remission rates between 25% and 75% and a 3-year probability of event-free survival between 40% and 60% but is not curative since most patients relapse after 1.5 to 3 years. Therefore, it becomes the treatment of choice for multiple myeloma. The drugs used in high dose therapy include: high dose melphalan (200 mg/m2) as single agent., melphalan (140 mg/m2) and total body irradiation (TBI), Busulfan and melphalan... etc. The use of the peripheral blood stem cell transplantation has allowed a reduction in the toxicity of high-dose regimens, but has not led to an increase in the overall response rate or survival. Hematopoietic stem cells from peripheral blood are preferred for transplantation because they restore hematopoiesis more rapidly than do bone marrow cells and the numbers of tumor cells are lower in peripheral blood than bone marrow cells. Peripheral blood stem cell transplantation was associated with significant reduction in the duration of aplasia and transfusion requirements. Several regimens have been proposed for stem cells mobilization including: High-dose cyclophosphamide and G or GM-CSF, G-CSF alone, and cyclophosphamide and etoposide with G-CSF... ect.. Further attempts to improve the results of autotransplantation have included intensification with tandem transplantations (double transplants) and reduction of tumor cells in stem cell infusion. The aim of this review is to summarize the current knowledge about the treatment of multiple myeloma with high dose chemotherapy with autologous hematopoietic stem cell transplantation.
Packaged frequency-stable tunable 20 kHz linewidth 1.5 μm InGaAsP external cavity laser (1985)

Packaged grating-tuned external cavity InGaAsP/InP lasers have been developed for use in coherent transmission systems that operate at a wavelength of 1.5 μm. The emission wavelength can be selected within a 60 nm range during manufacture, and can subsequently be tuned over 0.5 nm (63 GHz). The lasers have linewidths better than 20 kHz and show long-term relative frequency stability of better than 150 MHz.
Deletion of DNA lying close to the <i>glkA</i> locus induces ectopic sporulation in <i>Streptomyces coelicolor</i> A3(2) (1995)

Streptomyces coelicolor A3(2) J1668 sporulated ectopically in the substrate hyphae (the Esp phenotype) with the same time course as sporulation in the aerial hyphae. Examination of related strains implied that the Esp phenotype was caused by the deletion of DNA that lies close to, but is distinct from, the glucose kinase gene (glkA). Co-transduction of the Esp phenotype with the deletion present in J1668 confirmed this hypothesis. The size of the deletion was found to be 7.4 kb. Construction of a strain carrying both the J1668 deletion and a whiG mutation demonstrated that the Esp phenotype depends on at least one of the genes required for the differentiation of aerial hyphae into spores.
The QOS Broker [distributed multimedia computing] (1995)

In human affairs, brokers are intermediaries with specialized knowledge who work toward a mutually desirable outcome through negotiation. The QOS Broker is a software engineering technique that uses this principle to arrange for the delivery of end-to-end quality of service in distributed multimedia systems. An experimental prototype using a telerobotics application helped identify the technique's limitations and system requirements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nitrene Insertion into a C-H Bond at an Asymmetric Carbon Atom with Retention of Optical Activity. Thermally Generated Nitrenes (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitrene Insertion into a C-H Bond at an Asymmetric Carbon Atom with Retention of Optical Activity. Thermally Generated NitrenesGerald. Smolinsky and Bernice I. FeuerCite this: J. Am. Chem. Soc. 1964, 86, 15, 3085–3088Publication Date (Print):August 1, 1964Publication History Published online1 May 2002Published inissue 1 August 1964https://pubs.acs.org/doi/10.1021/ja01069a022https://doi.org/10.1021/ja01069a022research-articleACS PublicationsRequest reuse permissionsArticle Views850Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Breakdown voltages of base-collector junctions of high-voltage power transistors with graded collectors (1991)

Recent work on current-mode second breakdown shows that a substantial measure of protection against failure by avalanche injections can be built into a transitistor by grading the impurity concentrations of the collector. The breakdown voltage of the base-collector junction is an important parameter for power transistors. In this paper, the open-emitter breakdown voltage of an epitaxial bipolar high-power transistor with graded collector is computed numerically. A general expression for breakdown voltage as a function of initial collector doping (doping at the collector side of the base-collector interface) and collector parameters as a function of open-base bulk breakdown voltage and current gain are also derived.
Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety (2011)

pyrazolo[1,5- a ]pyrimidine, [1,2,4]triazolo[1,5- a ]pyrimidine and pyrimido[1,2- a ] benzimidazole derivatives were synthesized by reaction of sodium salt of 3-hydroxy-(1-pyridin-2-yl)prop-2-en-1-one or sodium salt of 3-hydroxy-1-(pyridin-3-yl)prop-2-en-1-one with different heterocyclic amines in piperidenium acetate. Also, 3-amino-6-(2-pyridyl)thieno[2,3- b ]pyridine derivatives were synthesized via reaction of pyridine-2-thione with various halogenated compounds. The structures of the newly synthesized compounds were confirmed by elemental analysis, spectral data, X-ray and alternative synthetic routes whenever possible.
A Family of Single-Isomer Chiral Resolving Agents for Capillary Electrophoresis. 2. Hepta-6-sulfato-β-cyclodextrin (1997)

A new, hydrophilic, single-isomer charged cyclodextrin, the sodium salt of hepta-6-sulfato-β-cyclodextrin has been synthesized, characterized, and used for the capillary electrophoretic separation of the enantiomers of numerous noncharged, acidic, basic, and zwitterionic analytes. Hepta-6-sulfato-β-cyclodextrin proved to be a much stronger complexing agent for all the analytes tested, in both low-pH and high-pH background electrolytes, than the previously synthesized, moderately hydrophobic heptakis(2,3-diacetyl-6-sulfato)-β-cyclodextrin. The separation selectivities of the two single-isomer, differently functionalized charged cyclodextrins often proved to be complementary. In agreement with the predictions of the charged resolving agent migration model, separation selectivity for the noncharged analytes decreased as the concentration of hepta-6-sulfato-β-cyclodextrin was increased. For acidic, basic, and zwitterionic analytes, selectivity could increase, decrease, or pass a maximum, depending on the binding strength of the enantiomers and ionic mobilities of both the complexed and noncomplexed forms of the enantiomers.
Gravitation and Inertia (1995)

PrefaceChart of Main Topics1A First Tour12Einstein Geometrodynamics133Tests of Einstein Geometrodynamics874Cosmology, Standard Models, and Homogeneous Rotating Models1855The Initial-Value Problem in Einstein Geometrodynamics2696The Gravitomagnetic Field and Its Measurement3157Some Highlights of the Past and a Summary of Geometrodynamics and Inertia384Mathematical Appendix403Symbols and Notations437Author Index445Subject Index of Mathematical Appendix455Subject Index461Fundamental and Astronomical Constants and Units493
Nucleophilic Phosphanylation of Fluoroaromatic Compounds with Carboxyl, Carboxymethyl, and Aminomethyl Functionalities − an Efficient Synthetic Route to Amphiphilic Arylphosphanes (1998)

Chiral- and multiply-carboxylated phosphanes and phosphanyl derivatives of benzoic and phthalic acids (1−9) are accessible in high yields by nucleophilic phosphanylation of potassium or lithium salts of commercially available fluorobenzoic and 3-fluorophthalic acids with Ph2PH, Ph2PK, PhPLi2 Ph(K)P−(CH2)3−P(K)Ph in superbasic media (DMSO/KOH) or in THF and DME. The hitherto unknown phosphanylphenylacetic acids (10−13) and phosphanylbenzylamines RR′P−C6H4−CH2− NH2 (14−19, R, R′ = H, Me, Ph) with unsubstituted amino groups were also synthesized by this method. The diphenylphosphanyl derivatives 14−16 (R, R′ = Ph) are accessible by an alternative method involving LiAlH4 reduction of the phosphanylbenzonitriles (20−22), which were obtained in high yields by nucleophilic phosphanylation of the corresponding fluoro- or chlorobenzonitriles. The novel bidentate phosphanylbenzonitrile 23 has also been obtained using this synthetic route. All compounds were completely characterized by elemental analysis, NMR spectroscopy, and mass spectrometry.
Evaluating Readiness for ERP Adoption in Manufacturing SMEs (2006)

Enterprise resource planning (ERP) systems are now being implemented in small- and medium-sized enterprises (SMEs). This paper presents the results of a study that proposes and validates a framework for evaluating the level of readiness for ERP adoption in manufacturing SMEs. The framework conceptualizes readiness to adopt an ERP including four dimensions: the organizational context, external forces, perception of ERP, and business processes. A field study of 11 manufacturing SMEs was conducted. The framework led to the classification of these firms in three clusters: “committed adopters”, “uncommitted adopters”, and “late adopters”.
Cognition and emotion in autonomous cars (2009)

In order to increase the acceptance of vehicles that drive (partly) autonomously, it seems advantageous that the driving style of autonomous cars is human-like. Furthermore, the acceptance of autonomous cars is believed to be increased when their actions and current state becomes more transparent to the passengers. These aspects can be tackled by implementing emotions to an autonomous car which allows a situation specific adaption of driving functions and vehicle dynamics. In this work, the emotions are modeled by the cognitive appraisal model as described by Ortony, Clore and Collins. The approach is presented for a traffic scene where two lanes are merged into one.
Apolipoprotein A-I mimetics (2014)

Despite the recent failure of therapies designed to raise HDL-cholesterol in humans, an approach to therapy using mimetics of HDL and its components continues to show promise.
Quantitative and Automated High-throughput Genome-wide RNAi Screens in <em>C. elegans</em> (2012)

RNA interference is a powerful method to understand gene function, especially when conducted at a whole-genome scale and in a quantitative context. In C. elegans, gene function can be knocked down simply and efficiently by feeding worms with bacteria expressing a dsRNA corresponding to a specific gene (1). While the creation of libraries of RNAi clones covering most of the C. elegans genome (2,3) opened the way for true functional genomic studies (see for example (4-7)), most established methods are laborious. Moy and colleagues have developed semi-automated protocols that facilitate genome-wide screens (8). The approach relies on microscopic imaging and image analysis. Here we describe an alternative protocol for a high-throughput genome-wide screen, based on robotic handling of bacterial RNAi clones, quantitative analysis using the COPAS Biosort (Union Biometrica (UBI)), and an integrated software: the MBioLIMS (Laboratory Information Management System from Modul-Bio) a technology that provides increased throughput for data management and sample tracking. The method allows screens to be conducted on solid medium plates. This is particularly important for some studies, such as those addressing host-pathogen interactions in C. elegans, since certain microbes do not efficiently infect worms in liquid culture. We show how the method can be used to quantify the importance of genes in anti-fungal innate immunity in C. elegans. In this case, the approach relies on the use of a transgenic strain carrying an epidermal infection-inducible fluorescent reporter gene, with GFP under the control of the promoter of the antimicrobial peptide gene nlp 29 and a red fluorescent reporter that is expressed constitutively in the epidermis. The latter provides an internal control for the functional integrity of the epidermis and nonspecific transgene silencing(9). When control worms are infected by the fungus they fluoresce green. Knocking down by RNAi a gene required for nlp 29 expression results in diminished fluorescence after infection. Currently, this protocol allows more than 3,000 RNAi clones to be tested and analyzed per week, opening the possibility of screening the entire genome in less than 2 months.
Efficient Level of Service Classification for Traffic Monitoring in the Compressed Video Domain (2012)

This paper presents a new method for estimating the level of service (LOS) on motorways in the compressed video domain. The method performs statistical computations on motion vectors of MPEG4 encoded video streams within a predefined region of interest to determine a set of four motion features describing the speed and density of the traffic stream. These features are fed into a Gaussian radial basis function network to classify the corresponding LOS. To improve the classification results, vectors of moving objects are clustered and outliers are eliminated. The proposed method is designed to be executed on a server system, where a large number of camera live streams can be analyzed in parallel in real-time. Evaluations with a comprehensive set of real-world training and test data from an Austrian motorway have shown an average accuracy of 86.7% on the test data set for classifying all four LOS levels. With a mean execution time of 48 microseconds per frame on a common server, hundreds of video streams can be analyzed in real-time.
Intermolecular Alkyne Hydroaminations Involving 1,1-Disubstituted Hydrazines (2002)

[reaction: see text] Two readily prepared catalysts have been developed for the hydroamination of alkynes by 1,1-disubstituted hydrazines. The catalyses are facile with terminal alkynes and some internal alkynes. If the hydrazine bears an aryl group, Fischer cyclization can occur in a one-pot procedure. In addition, reactions with acetylene to produce a plethora of hydrazones are described. Catalytic reactions involving acetylene and substituted hydrazines are complete in less than 2 h at room temperature and 1 atm of pressure.
Electropermanent magnet actuation for droplet ferromicrofluidics (2016)

Droplet actuation is an essential mechanism for droplet-based microfluidic systems. On-demand electromagnetic actuation is used in a ferrofluid-based microfluidic system for water droplet displacement. Electropermanent magnets (EPMs) are used to induce 50 mT magnetic fields in a ferrofluid filled microchannel with gradients up to 6.4 × 10<sup>4</sup> kA/m<sup>2</sup>. Short 50 µs current pulses activate the electropermanent magnets and generate negative magnetophoretic forces that range from 10 to 70 nN on 40 to 80 µm water-in-ferrofluid droplets. Maximum droplet displacement velocities of up to 300 µm/s are obtained under flow and no-flow conditions. Electropermanent magnet-activated droplet sorting under continuous flow is demonstrated using a split-junction microfluidic design.
The Problems of Delivering Neuroactive Molecules to the CNS (2007)

At present, the aetiologies of many neurological and neurodegenerative diseases are unknown. However, emergence of a better understanding of these diseases, at both cellular and molecular levels, opens up the possibility of replacement therapies. The presence of the blood-brain barrier complicates the delivery of molecules to the central nervous system. Numerous attempts have been made to bypass this barrier either by delivering the drugs directly into the brain or by transplanting cells to produce the missing molecules in situ. This review explores several methods for delivering bioactive molecules into the CNS, including the use of permeabilizers, osmotic pumps, slow polymer release systems and transplantation of cells with or without the use of the encapsulation technology.