gebhart/patrepeval huggingface dataset:
Laser-assisted chemical vapor deposition of Si: Low-temperature (&lt;600 °C) growth of epitaxial and polycrystalline layers (1985)

Pulsed KrF laser irradiation (248-nm or 5-eV photons) during the chemical vapor deposition of Si from SiH4 has been used to periodically melt and rapidly resolidify thin layers of continuously deposited material. From one-dimensional heat-flow calculations, the increase in the average film growth temperature for the conditions used in these experiments was less than 1° C, the melt depth ranged from ∼5 to 40 nm, and the resolidification velocity was 2 to 3 ms−1. By proper choice of laser energy density E, pulse repetition rate f, and film deposition rate R, the melt depth was adjusted to correspond to a value slightly larger than the film thickness deposited between pulses. Using this procedure, we have grown polycrystalline Si films on SiO2 and Si single crystals on (100)Si substrates at average growth temperatures Ts between 535 and 650 °C. The polycrystalline films had average grain sizes of 1 to 2 μm with a (111) preferred orientation. Films grown without laser irradiation, but otherwise under the same conditions, were amorphous at Ts&lt;580 °C and fine-grained polycrystalline at higher temperatures. The room-temperature conductivity of irradiated In-doped polycrystalline films grown at Ts=565 °C was ∼5 orders of magnitude higher than the conductivity of unirradiated films. Irradiated single-crystal films doped with B exhibited room-temperature hole mobilities which were near the maximum theoretical bulk values for the corresponding carrier concentrations (∼1018 cm−3).
All Members of the MHC Multigene Family Respond to Thyroid Hormone in a Highly Tissue-Specific Manner (1986)

In mammals different isoforms of myosin heavy chain are encoded by the members of a multigene family. The expression of each gene of this family is regulated in a tissue- and developmental stage-specific manner as well as by hormonal and various pathological stimuli. In this study the molecular basis of isoform switches induced in myosin heavy chain by thyroid hormone was investigated. The expression of the myosin heavy chain gene family was analyzed in seven different muscles of adult rats subjected to hypo- or hyperthyroidism with complementary DNA probes specific for six different myosin heavy chain genes. The results demonstrate that all six genes are responsive to thyroid hormone. More interestingly, the same myosin heavy chain gene can be regulated by thyroid hormone in highly different modes, even in opposite directions, depending on the tissue in which it is expressed. Furthermore, the skeletal embryonic and neonatal myosin heavy chain genes, so far considered specific to these two developmental stages, can be reinduced by hypothyroidism in specific adult muscles.
Detection of a Precursor Polypeptide of the Rapidly-Synthesized 32,000-Dalton Thylakoid Protein in Spinach Chloroplasts (1985)

Spinach chloroplast RNA was translated in a wheat germ cell-free system in the presence of [35S]methionine or [3H]lysine, and the products were analyzed by SDS polyacrylamide gel electrophoresis and fluorography. A polypeptide with molecular mass of 2,000-Da larger than the 32,000-Da thylakoid protein was detected as a major product labeled by [35S]methionine but not by [3H]lysine. Peptide mapping of this polypeptide showed a pattern very close to that of the 32,000-Da protein synthesized in isolated chloroplasts. A better separation of this polypeptide from the 32,000-Da protein was observed in the electrophoresis on polyacrylamide gel including urea at 8 m. Pulse-labeling of the isolated chloroplasts showed the occurrence of the larger molecular weight form, which was converted to the mature size by a chasing incubation with cold methionine. These results suggested that the 32,000-Da protein of spinach is translated primarily as a high molecular weight precursor in the chloroplasts, as has been reported for other plant species.
Solvothermal Synthesis and Luminescence Properties of BaCeF<sub>5</sub>, and BaCeF<sub>5</sub>: Tb<sup>3+</sup>, Sm<sup>3+</sup> Nanocrystals: An Approach for White Light Emission (2012)

Novel monodisperse BaCeF5 and BaCeF5: Tb3+, Sm3+ nanocrystals have been successfully synthesized by a simple one-step solvothermal synthesis. Uniformly distributed nanocrystals with an octahedral morphology and particle size of 75–80 nm were observed. X-ray diffraction (XRD), field emission-scanning electron microscopy (FE-SEM), photoluminescence (PL), and decay studies were employed to characterize the samples. Under ultraviolet irradiation, the BaCeF5: Tb3+, Sm3+ samples exhibit the typical green emission band of the Tb3+ ions, as well as an orange-red and red emission bands of the Sm3+ ions in the presence of Ce3+ ions. The highly intense orange-red and red emission bands of the Sm3+ ions were attributed to the effective energy transfer from the Tb3+ to Sm3+ ions, which has been justified through the luminescence spectra and the fluorescence decay dynamics. The luminescence colors of BaCeF5: Tb3+, Sm3+ nanophosphors can be easily tuned by changing the concentration of Sm3+ ions. These results suggest that BaCeF5: Tb3+, Sm3+ nanocrystals can be explored for three-dimensional displays, back lighting, white light sources, and so on.
Surface Cooling of a Pool Fire by Aqueous Foams (2016)

We model an idealized case of heat transfer relevant for foams used to suppress pool fires wherein an ambient-temperature firefighting foam is placed uniformly and instantaneously on top of a hot fuel pool with a boiling point slightly lower than that of water. We performed experiments using n-heptane fuel and both commercial fluorinated (AFFF) and non-fluorinated (RF6) foams. The measurements show rapid (<10 s) and significant (25°C) cooling of the fuel close to the foam-fuel interface in good agreement with the model predictions. The model also shows that a 60-µm-thick static, aqueous film formed between the foam and fuel surface has a negligible effect on interfacial cooling. Therefore, in addition to forming a fuel-transport barrier to the fire, the foam layer rapidly cools the surface by heat conduction and suppresses fuel evaporation, which suppresses the pool fire.
Tissue Plasminogen Activator Inhibits Reactive Oxygen Species Production by Macrophages (2000)

Our results suggest that tPA has broad inhibitory effects on inflammatory cell ROS production. In diseases such as atherosclerosis and acute respiratory distress syndrome, these data suggest the possible utility of exogenous tPA as an antiinflammatory agent and a physiologic role for endogenous tPA that goes beyond maintenance of homeostasis.
FPGA based implementation of a double precision IEEE floating-point adder (2013)

Floating-Point addition imposes a great challenge during implementation of complex algorithm in hard real-time due to the enormous computational burden associated with repeated calculations with high precision numbers. Moreover, at the hardware level, any basic addition or subtraction circuit has to incorporate the alignment of the significands. This paper presents a novel technique to implement a double precision IEEE floating-point adder that can complete the operation within two clock cycles. The proposed technique has exhibited improvement in the latency and also in the operational chip area management. The proposed double precision IEEE floating-point adder has been implemented with XC2V6000 and XC3S1500 Xilinx <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">©</sup> FPGA devices.
Contribution of <i>Vibrio parahaemolyticus</i> Virulence Factors to Cytotoxicity, Enterotoxicity, and Lethality in Mice (2010)

Vibrio parahaemolyticus, one of the human-pathogenic vibrios, causes three major types of clinical illness: gastroenteritis, wound infections, and septicemia. Thermostable direct hemolysin (TDH) secreted by this bacterium has been considered a major virulence factor of gastroenteritis because it has biological activities, including cytotoxic and enterotoxic activities. Previous reports revealed that V. parahaemolyticus strain RIMD2210633, which contains tdh, has two sets of type III secretion system (T3SS) genes on chromosomes 1 and 2 (T3SS1 and T3SS2, respectively) and that T3SS1 is responsible for cytotoxicity and T3SS2 is involved in enterotoxicity, as well as in cytotoxic activity. However, the relative importance and contributions of TDH and the two T3SSs to V. parahaemolyticus pathogenicity are not well understood. In this study, we constructed mutant strains with nonfunctional T3SSs from the V. parahaemolyticus strain containing tdh, and then the pathogenicities of the wild-type and mutant strains were evaluated by assessing their cytotoxic activities against HeLa, Caco-2, and RAW 264 cells, their enterotoxic activities in rabbit ileal loops, and their lethality in a murine infection model. We demonstrated that T3SS1 was involved in cytotoxic activities against all cell lines used in this study, while T3SS2 and TDH had cytotoxic effects on a limited number of cell lines. T3SS2 was the major contributor to V. parahaemolyticus-induced enterotoxicity. Interestingly, we found that both T3SS1 and TDH played a significant role in lethal activity in a murine infection model. Our findings provide new indications that these virulence factors contribute to and orchestrate each distinct aspect of the pathogenicity of V. parahaemolyticus.
Grafting an RGD motif onto an epidermal growth factor‐like module: chemical synthesis and functional characterization of the chimeric molecule (1999)

A novel protein was engineered by inserting the GRGDS motif of fibronectin within the 14-residue loop of the EGF-like module from human complement protease C1r. The resulting chimeric EGF-RGD module (52 residues, three disulfide bridges) was assembled by automated solid-phase synthesis using the t-Boc strategy. Using reduced/oxidized glutathione, the EGF-RGD module was folded as efficiently as the natural C1r-EGF module, resulting in formation of the appropriate disulfide bridge pattern as shown by mass spectrometry and N-terminal sequence analyses of thermolytic fragments. Circular dichroism and NMR measurements provided further indication that introduction of the GRGDS motif had no significant effect on the folding. Using Chinese Hamster Ovary (CHO) cells bearing the integrin receptors specific for fibronectin and vitronectin, EGF-RGD was shown to induce cell adhesion via the introduced GRGDS motif. Cell binding was inhibited specifically and efficiently by the synthetic peptide GRGDSP and by fibronectin, and to a much lesser extent by vitronectin, whereas the monoclonal antibody PB1 directed to the alpha5 subunit of alpha5beta1 integrin had no effect. The ability of EGF-RGD to trigger significant cell spreading and intracellular signaling was also demonstrated using immunofluorescence and confocal microscopy.
Analysis of Immune Responses against T- and B-Cell Epitopes from<i>Plasmodium falciparum</i>Liver-Stage Antigen 1 in Rodent Malaria Models and Malaria-Exposed Human Subjects in India (2000)

Liver-stage antigen 1 (LSA-1) is a potential vaccine candidate against preerythrocytic stages of malaria. We report here the immunogenicity of linear synthetic constructs delineated as T(H)-cell determinants from the nonrepeat regions of Plasmodium falciparum LSA-1 in murine models and human subjects from areas where malaria is endemic in Rajasthan State, India. Seven peptide constructs (LS1.1 to LS1.7) corresponding to predicted T-cell sites from both the N- and C-terminal regions and peptide LS1R from a repeat region of PfLSA-1 were synthesized to analyze the cellular immune responses. These linear peptides were also tested for humoral responses in order to determine if there were any overlapping B-cell epitopes in the predicted T-cell sites. Most peptides induced cellular responses in peptide-immunized BALB/c and C57BL/6 mice as measured by proliferation and cytokine analysis. Cross-reactive T-cell recognition of P. falciparum-based peptides in Plasmodium berghei-immune animals was evaluated, but only one peptide, LS1.2 (amino acids 1742 to 1760) triggered T-cell proliferation and interleukin-2 and gamma interferon secretion in P. berghei-immune splenocytes of BALB/c and C57BL/6 mice as well as in Thamnomys gazellae (natural host of P. berghei ANKA). In an enzyme-linked immunosorbent assay with the peptides, only one peptide, LS1.1, was recognized by anti-P. berghei liver-stage serum. Three peptides (LS1. 1, LS1.2, and LS1.3) of the eight peptides tested in this study were recognized by a relatively large percentage of P. falciparum-exposed human subjects; the reactivities ranged from approximately 45% for LS1.3 to approximately 60% for LS1.1 and LS1.2. Interestingly, all of the eight putative T-cell determinants were also recognized by the sera collected from malaria patients, although the response was variable in nature. These T(H)- and B-cell epitopes may be of potential value for preerythrocytic antigen-based malaria subunit vaccine formulations.
Prediction of Efficacy of Vabicaserin, a 5‐HT<sub>2C</sub> Agonist, for the Treatment of Schizophrenia Using a Quantitative Systems Pharmacology Model (2014)

A quantitative systems pharmacology model that combines in vitro/preclinical neurophysiology data, human imaging data, and patient disease information was used to blindly predict steady-state clinical efficacy of vabicaserin, a 5-HT2C full agonist, in monotherapy and, subsequently, to assess adjunctive therapy in schizophrenia. The model predicted a concentration-dependent improvement of positive and negative syndrome scales (PANSS) in schizophrenia monotherapy with vabicaserin. At the exposures of 100 and 200 mg b.i.d., the predicted improvements on PANSS in virtual patient trials were 5.12 (2.20, 8.56) and 6.37 (2.27, 10.40) (mean (95% confidence interval)), respectively, which are comparable to the observed phase IIa results. At the current clinical exposure limit of vabicaserin, the model predicted an ~9-point PANSS improvement in monotherapy, and <4-point PANSS improvement adjunctive with various antipsychotics, suggesting limited clinical benefit of vabicaserin in schizophrenia treatment. In conclusion, the updated quantitative systems pharmacology model of PANSS informed the clinical development decision of vabicaserin in schizophrenia.
NDE technologies for the examination of heat exchangers and boiler tubes – principles, advantages and limitations (2006)

Several NDE examination methods are currently being used to inspect heat exchangers and boiler tubes. The tube material of this equipment is made from various ferromagnetic and non-ferromagnetic alloys. The tubes’ sizes vary from 0.5-3.5 inches in outside diameter and from 0.028-0.120 inches in wall thickness. This paper outlines the principles, applications, advantages and limitations of each of the following NDE methods used for these inspections:
Marine engine external exhaust noise suppressor with swim platform (1991)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation George Von Widmann, Robert V. Parenti; Marine engine external exhaust noise suppressor with swim platform. J. Acoust. Soc. Am. 1 October 1991; 90 (4): 2216. https://doi.org/10.1121/1.401616 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Saving/recording citations for future use (2009)

This chapter contains sections titled: Logbooks Software
Long-Term Effect of Diabetes and Pregnancy in the Rat (1985)

Islet hyperplasia and B-cell degranulation were found in the fetuses of the third generation from mothers (second generation) born to a diabetic mother (first generation) regardless of the origin of the father, while pancreatic islets were normal in fetuses from control mothers, even when the father was an offspring of a diabetic mother. These data support the hypothesis that in our experimental model overstimulation of the fetal endocrine pancreas results in long-term consequences to the third generation.
Micro-Drone for Wind Vector Estimation and Gas Distribution Mapping (2011)

Abstract—This paper presents the development and validation of an autonomous gas-sensitive micro-drone, which is capable of estimating the wind vector in real time using only the on-board control unit of the micro-drone and performing gas distribution mapping. Two different sampling approaches are suggested in order to address this problem. On one hand, a predefined trajectory is used to explore the target area with the microdrone in a real-world gas distribution mapping experiment. As an alternative sampling approach we introduce an adaptive strategy, which suggests next sampling points based on an Artificial Potential Field (APF). Initial results in real-world experiments demonstrate the capability of the proposed adaptive sampling strategy for gas distribution mapping and its use for gas source localization. Index Terms—anemometric sensor, autonomous Micro UAV, chemical sensing, gas distribution modeling, gas source localization, gas sensors, mobile sensing system, quadrocopter, sensor planning, artificial potential field. I.
Mechanism of action of macrophage-derived suppressor factor produced by soluble immune response suppressor-treated macrophages. (1981)

After a 2-hr incubation with soluble immune response suppressor (SIRS), a product of concanavalin A-activated murine T cells, macrophages release a factor, M phi-derived suppressor factor (M phi-SF), which nonspecifically suppresses immune responses in vitro. The mechanism(s) of action of M phi-SF and range of cell types affected by M phi-SF have been investigated. M phi-SF suppressed antibody responses to background levels if added at culture initiation and by 80 to 90% if added as late as 2 hr before assay. Primary and secondary IgM and IgG antibody responses, proliferative responses to T cell and B cell mitogens, antibody and protein secretion, and the division of several tumor cell lines in culture were inhibited by M phi-SF. Division of synchronized tumor cells was inhibited when M phi-SF was added at any point prior to and during mitosis; this inhibition could be reversed with 2-mercaptoethanol. In the presence of M phi-SF, asynchronous tumor cells accumulated in the cell cycle just prior to cell division and could be released into mitosis by 2-mercaptoethanol. These data indicate that M phi-SF inhibits cell division by causing a block at or in mitosis and suggest that M phi-SF may be a general inhibitor of cellular proliferation and possibly of protein secretion.
Raloxifene, a mixed estrogen agonist/antagonist, induces apoptosis in androgen-independent human prostate cancer cell lines. (2002)

Raloxifene, a selective estrogen receptor (ER) modulator, is a mixed estrogen agonist/antagonist that has been shown to prevent osteoporosis and breast cancer in women. Because the prostate contains high levels of ER-beta, the present study investigated the effect of raloxifene in three well-characterized, androgen-independent human prostate cancer cell lines: (a) PC3; (b) PC3M; and (c) DU145. Reverse transcriptase-PCR and Western blot analysis for ER-alpha and ER-beta demonstrated that all three cell lines express ER-beta, whereas only PC3 and PC3M cells were positive for ER-alpha. After the treatment with raloxifene, a dramatic increase in cell death was observed in a dose-dependent manner in the three prostate cancer cell lines (10(-9) to 10(-6) M range). Because the three prostate cancer cell lines demonstrated similar morphological changes after the raloxifene treatment, PC3 (ER-alpha/ER-beta+) and DU145 (ER-beta+ only) cells were selected to further characterize the raloxifene-induced cell death. Using the nucleus-specific stain 4',6-diamidino-2-phenylindole, nuclear fragmentation was observed in a time-dependent manner in both cell lines after exposure to 10(-6) M raloxifene. Using the terminal deoxynucleotidyl transferase-mediated nick end labeling apoptotic assay, it was demonstrated that the nuclear fragmentation was caused by apoptosis. To investigate the possibility that caspase activation is involved in raloxifene-induced apoptosis, cells were treated with the pan-caspase inhibitor ZVAD. The results demonstrated that the dramatic change in cellular morphology after treatment with raloxifene was no longer observed when cells were pretreated with ZVAD. Immunoblot demonstrated activation of caspases 8 and 9 in PC3 and DU145 cells, respectively. Taken together, these results demonstrate that the mixed estrogen agonist/antagonist, raloxifene, induces apoptosis in androgen-independent human prostate cancer cell lines.
Schaum's Outline of Computer Networking (2002)

Schaum's Outline of Computer Networking introduces the underlying concepts, principles, and terminology of computer networks. Covering the full scope of material taught in computer networking courses, this problem-solved approach presents the different components of a network and shows how these components fit together as well as explaining the varied harmonizing functions needed for the interconnection of many heterogeneous computer networks.
A Dose Ranging Study to Evaluate Dermatan Sulphate in Preventing Deep Vein Thrombosis following Total Hip Arthroplasty (1994)

Dermatan sulphate catalyses thrombin inhibition by heparin cofactor II; it has a lower haemorrhagic to antithrombotic ratio than that of heparin in animal models. Consecutive patients aged forty years or more, electively undergoing total hip replacement under general anaesthesia, were randomly allocated to one of three dosage regimens of dermatan sulphate (MF701, Mediolanum Farmaceutici) given intramuscularly. These were 200 mg once daily (n = 50), 200 mg twice daily (n = 52) and 300 mg twice daily (n = 51), administered from twenty-four hours pre-operatively until the tenth postoperative day. The overall incidence of DVT assessed by bilateral venography was 53%, 51% and 34% respectively (Chi-square test for trend p = 0.06). The incidence of major proximal DVT was 10.6%, 8.5% and 2.1% respectively. Pulmonary embolism (PE) and bleeding were assessed in all 153 patients. There was one case of PE in each dose group. The incidence of bleeding episodes, volume of blood lost and blood transfusion requirements were low and showed no increase with increasing dose. The patients were followed up 4-8 weeks after discharge. We conclude that the two lower doses were subtherapeutic in this population, however dermatan sulphate given 300 mg twice daily, proved to be efficacious with an incidence of proximal major DVT of 2.1% and a low incidence of bleeding complications. A trial of dermatan sulphate 300 mg twice daily compared to standard prophylactic agents is needed.