gebhart/patrepeval huggingface dataset:
Experimental and Theoretical Studies of Quadrupolar Oligothiophene‐Cored Chromophores Containing Dimesitylboryl Moieties as π‐Accepting End‐Groups: Syntheses, Structures, Fluorescence, and One‐ and Two‐Photon Absorption (2014)

Quadrupolar oligothiophene chromophores composed of four to five thiophene rings with two terminal (E)-dimesitylborylvinyl groups (4 V-5 V), and five thiophene rings with two terminal aryldimesitylboryl groups (5 B), as well as an analogue of 5 V with a central EDOT ring (5 VE), have been synthesized via Pd-catalyzed cross-coupling reactions in high yields (66-89%). Crystal structures of 4 V, 5 B, bithiophene 2 V, and five thiophene-derived intermediates are reported. Chromophores 4 V, 5 V, 5 B and 5 VE have photoluminescence quantum yields of 0.26-0.29, which are higher than those of the shorter analogues 1 V-3 V (0.01-0.20), and short fluorescence lifetimes (0.50-1.05 ns). Two-photon absorption (TPA) spectra have been measured for 2 V-5 V, 5 B and 5 VE in the range 750-920 nm. The measured TPA cross-sections for the series 2 V-5 V increase steadily with length up to a maximum of 1930 GM. We compare the TPA properties of 2 V-5 V with the related compounds 5 B and 5 VE, giving insight into the structure-property relationship for this class of chromophore. DFT and TD-DFT results, including calculated TPA spectra, complement the experimental findings and contribute to their interpretation. A comparison to other related thiophene and dimesitylboryl compounds indicates that our design strategy is promising for the synthesis of efficient dyes for two-photon-excited fluorescence applications.
Prompt Response Self-Powered Neutron Detectors I: The Effective Charge per Neutron Captured (1987)

A simple, physically transparent method is developed to calculate the electric charge per neutron captured in prompt response self-powered neutron detectors (SPNDs), which contributes to the emitter-collector current.This charge is written as the energy integral of the product of two functions: the spectral function S(E), which is the energy spectrum of all electrons resulting from prompt gamma interactions with the atoms of the emitter, and the electron spectral contribution ∊f(E), which is the probability that an electron released with energy E reaches the collector. The function ∊f(E) is given an analytical approximate expression derived from an analytical approximation obtained for the path length probability distribution function. The exact expression of ∊f(E) is also obtained analytically for infinitely long emitters in terms of special functions.The method allowed the creation of an extremely fast algorithm to calculate the effective charge and was applied to cobalt prompt response SPNDs.
Area-Efficient QC-LDPC Decoder Architecture Based on Stride Scheduling and Memory Bank Division (2013)

In this paper, an area-efficient decoder architecture is proposed for the quasi-cyclic low-density parity check (QC-LDPC) codes specified in the IEEE 802.16e WiMAX standard. The decoder supports all the code rates and codeword lengths defined in the standard. In order to achieve low area and maximize hardware utilization, the decoder utilizes 4 decoding function units, which is the greatest common divisor of the expansion factors. In addition, the decoder adopts a novel scheduling scheme named stride scheduling, which stores the extrinsic messages in non-sequential order to replace the conventional complex flexible permutation network with simple small-sized cyclic shifters and also minimize the number of memory accesses. To further minimize the complexity, the number of extrinsic memory instances for 24 block columns is reduced to 5 banks by identifying independent sets. All the memory instances used in the decoder are single-port memories which cost less area and price compared to dual-port ones. Finally, the decoding function units have partially parallel structure to make the decoding throughput sufficiently over the requirement of the WiMAX standard. The proposed decoder is synthesized with 49K equivalent gates and 54,144bits of memory, and the implementation occupies 0.40mm2 in a 65nm CMOS technology.
DNA Methylation as a Biomarker in Breast Cancer (2009)

In cancer, epigenetic changes such as covalent addition of methyl groups to the genomic DNA itself are more prominent than genetic changes. Cytosine-phosphate-guanosine (CpG) methylation negatively affects gene transcription of an adjacent gene. It is thought that DNA methylation significantly contributes to all hallmarks of cancer. Next to being a potential therapy target, DNA methylation is an emerging field of biomarkers. Technically, DNA provides a stable and robust analyte that is particularly suitable for clinical applications. Moreover, there are numerous potential human DNA sources that could facilitate integration of methylation tests in clinical practice. In breast cancer, DNA methylation has shown promise as a potential biomarker for early detection, therapy monitoring, assessment of prognosis or prediction of therapy response. In particular, paired-like homeodomain transcription factor 2 (PITX2) DNA methylation has been validated using a robust assay for paraffin-embedded tissue for clinically relevant outcome prediction in early breast cancer patients treated by adjuvant tamoxifen therapy.
Managing Linux systems with Webmin: system administration and module development (2004)

From the Publisher:
Easy, browser-based Linux/UNIX administration with Webmin--step by step

Webmin gives you an easy, browser-based solution for virtually any day-to-day Linux/UNIX administration task. Now, there's a definitive Webmin guide for every beginning-to-intermediate sysadmin. Written by Webmin's primary developer, Managing Linux Systems with Webmin delivers authoritative, step-by-step coverage of the latest version of Webmin, from basic installation to centrally managing multiple servers. Coverage includes: 

How Webmin works--and how to install and secure it
Using Webmin to configure basic system services, including filesystems, users/groups, and printing
Configuring Apache, Sendmail, Squid, Samba, MySQL, PostgreSQL, FTP services, and more 
Cluster modules: configuring multiple systems from one master server
Webmin modules: configuring Webmin itself
Full API documentation and instructions for writing your own Webmin modules and themes


Jamie Cameron walks you through more than 50 essential Webmin tasks--offering all the background you need, step-by-step instructions, extensive screen captures, and listings of the underlying configuration files that are being modified. Whether you're new to Linux/UNIX system administration or you simply want an alternative to the command line, Managing Linux Systems with Webmin will be an indispensable resource.
ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category (2011)

The associations of mutations in the enhancer of trithorax and polycomb family gene ASXL1 with pretreatment patient characteristics, outcomes, and gene-/microRNA-expression profiles in primary cytogenetically normal acute myeloid leukemia (CN-AML) are unknown. We analyzed 423 adult patients for ASXL1 mutations, other prognostic gene mutations, and gene-/microRNA-expression profiles. ASXL1 mutations were 5 times more common in older (≥ 60 years) patients (16.2%) than those younger than 60 years (3.2%; P < .001). Among older patients, ASXL1 mutations associated with wild-type NPM1 (P < .001), absence of FLT3-internal tandem duplications (P = .002), mutated CEBPA (P = .01), and with inferior complete remission (CR) rate (P = .04), disease-free survival (DFS; P = .03), overall survival (OS; P = .006), and event-free survival (EFS; P = .002). Within the European LeukemiaNet (ELN) genetic categories of older CN-AML, ASXL1 mutations associated with inferior CR rate (P = .02), OS (P < .001), and EFS (P < .001) among ELN Favorable, but not among ELN Intermediate-I patients. Multivariable analyses confirmed associations of ASXL1 mutations with unfavorable CR rate (P = .03), DFS (P < .001), OS (P < .001), and EFS (P < .001) among ELN Favorable patients. We identified an ASXL1 mutation-associated gene-expression signature, but no microRNA-expression signature. This first study of ASXL1 mutations in primary CN-AML demonstrates that ASXL1-mutated older patients, particularly within the ELN Favorable group, have unfavorable outcomes and may be candidates for experimental treatment approaches.
The High Prevalence of Diabetes in a Large Cohort of Patients Drawn From Safety Net Clinics (2016)

The ADVANCE diabetes cohort offers an opportunity to conduct epidemiologic and comparative effectiveness research on underserved and underrepresented individuals, who have a higher prevalence of diabetes than the general US population.
Tomographic Imaging of a Forested Area By Airborne Multi-Baseline P-Band SAR (2008)

In recent years, various attempts have been undertaken to obtain information about the structure of forested areas from multi-baseline synthetic aperture radar data. Tomographic processing of such data has been demonstrated for airborne L-band data but the quality of the focused tomographic images is limited by several factors. In particular, the common Fourierbased focusing methods are susceptible to irregular and sparse sampling, two problems, that are unavoidable in case of multi-pass, multi-baseline SAR data acquired by an airborne system. In this paper, a tomographic focusing method based on the time-domain back-projection algorithm is proposed, which maintains the geometric relationship between the original sensor positions and the imaged target and is therefore able to cope with irregular sampling without introducing any approximations with respect to the geometry. The tomographic focusing quality is assessed by analysing the impulse response of simulated point targets and an in-scene corner reflector. And, in particular, several tomographic slices of a volume representing a forested area are given. The respective P-band tomographic data set consisting of eleven flight tracks has been acquired by the airborne E-SAR sensor of the German Aerospace Center (DLR).
BMS-193884 and BMS-207940 Bristol-Myers Squibb. (2002)

Bristol-Myers Squibb is developing BMS-193884, an oral endothelin antagonist, for the potential treatment of congestive heart failure (CHF) and pulmonary hypertension [206604]. The compound entered phase I trials in November 1996 [242721] and had progressed to phase II trials [399460], [441398]. Structural modifications led to the development of a second-generation analog, BMS-207940, a biphenylsulfonamide endothelin A receptor-selective antagonist, and the probable discontinuation of the first clinical candidate, BMS-193884 [446511]. By April 2002, BMS-207940 was in phase I trials [446511]. By March 2002, filing for NDA was expected to take place in 2004 at the earliest [452734].
The C-terminal domain of myosin-like protein 1 (Mlp1p) is a docking site for heterogeneous nuclear ribonucleoproteins that are required for mRNA export (2003)

For mRNA to be transported from the nucleus to the cytoplasm, it must travel from the site of transcription through the nuclear interior to the nuclear pore. Studies in Saccharomyces cerevisiae have suggested a relationship between poly(A) RNA trafficking and myosin-like protein 1 (Mlp1p), a nuclear-pore associated protein that is homologous to the mammalian Tpr (translocated promoter region) protein [Kosova, B., Panté, N., Rollenhagen, C., Podtelejnikov, A., Mann, M., Aebi, U., and Hurt, E. (2000) J. Biol. Chem. 275, 343-350]. We identified a yeast two-hybrid interaction between the C-terminal globular domain of Mlp1p and Nab2p, a shuttling heterogeneous nuclear ribonucleoprotein that is required for mRNA export. Coimmunoprecipitation confirms that Nab2p also interacts with full-length Mlp1p and in vitro binding experiments show that Nab2p binds directly to the C-terminal domain of Mlp1p. In addition, our experiments reveal that the C-terminal domain of Mlp1p is both necessary and sufficient to cause accumulation of poly(A) RNA and Nab2p in the nucleus. We propose a model where Mlp1p acts as a checkpoint at the nuclear pore by interacting with export-competent ribonucleoprotein complexes through its C-terminal globular domain. This study identifies Nab2p as a heterogeneous nuclear ribonucleoprotein found in complex with Mlp1p and begins to delineate the path that mRNA travels from the chromatin to the nuclear pore.
Advances in Photocatalytic CO2 Reduction with Water: A Review (2017)

In recent years, the increasing level of CO₂ in the atmosphere has not only contributed to global warming but has also triggered considerable interest in photocatalytic reduction of CO₂. The reduction of CO₂ with H₂O using sunlight is an innovative way to solve the current growing environmental challenges. This paper reviews the basic principles of photocatalysis and photocatalytic CO₂ reduction, discusses the measures of the photocatalytic efficiency and summarizes current advances in the exploration of this technology using different types of semiconductor photocatalysts, such as TiO₂ and modified TiO₂, layered-perovskite Ag/ALa₄Ti₄O<sub>15</sub> (A = Ca, Ba, Sr), ferroelectric LiNbO₃, and plasmonic photocatalysts. Visible light harvesting, novel plasmonic photocatalysts offer potential solutions for some of the main drawbacks in this reduction process. Effective plasmonic photocatalysts that have shown reduction activities towards CO₂ with H₂O are highlighted here. Although this technology is still at an embryonic stage, further studies with standard theoretical and comprehensive format are suggested to develop photocatalysts with high production rates and selectivity. Based on the collected results, the immense prospects and opportunities that exist in this technique are also reviewed here.
<title>Compact optical tape recording system</title> (1994)

A new optical tape recorder, based on a very fast rotating polygon is described. This system combines a high data rate with a high storage density and fast access. The recorder is compact and, apart from the polygon, requires only simple mechanics.
Black-White Disparities in Overweight and Obesity Trends by Educational Attainment in the United States, 1997–2008 (2013)

BMI increased steadily in all race-sex and education groups from 1997 to 2008, and blacks (particularly women) had a consistently higher BMI than their white counterparts. Overweight/obesity trends and racial disparities were more prominent among individuals with higher education levels, compared to their counterparts with lower education levels.
An 81-MHz IF receiver in CMOS (1996)

An 81-MHz CMOS IF receiver for digital wireless applications is presented. The receiver consists of a continuous-time IF amplifier, a subsampling switched-capacitor gain stage, and a sixth-order bandpass /spl Sigma//spl Delta/ A/D converter. Incorporating 24 dB of programmable gain, the receiver achieves 92 dB of dynamic range in a 200 kHz bandwidth. Due to its IF sampling nature, the reciever is immune to de offset, flicker noise, and errors due to mismatches between I and Q signal paths. By utilizing a pseudo two-path resonator architecture in the bandpass /spl Sigma//spl Delta/ A/D converter, a stable passband center frequency which is immune to capacitor mismatch is achieved. Implemented in 0.8-/spl mu/m CMOS, this chip uses a single 3 V supply and consumes 14.4 mW of power.
Proteomic analysis of neural differentiation of mouse embryonic stem cells (2005)

Mouse embryonic stem cells (mESCs) can differentiate into different types of cells, and serve as a good model system to study human embryonic stem cells (hESCs). We showed that mESCs differentiated into two types of neurons with different time courses. To determine the global protein expression changes after neural differentiation, we employed a proteomic strategy to analyze the differences between the proteomes of ES cells (E14) and neurons. Using 2-DE plus LC/MS/MS, we have generated proteome reference maps of E14 cells and derived dopaminergic neurons. Around 23 proteins with an increase or decrease in expression or phosphorylation after differentiation have been identified. We confirmed the downregulation of translationally controlled tumor protein (TCTP) and upregulation of alpha-tubulin by Western blotting. We also showed that TCTP was further downregulated in derived motor neurons than in dopaminergic neurons, and its expression level was independent of extracellular Ca(2+) concentration during neural differentiation. Potential roles of TCTP in modulating neural differentiation through binding to Ca(2+), tubulin and Na,K-ATPase, as well as the functional significance of regulation of other proteins such as actin-related protein 3 (Arp3) and Ran GTPase are discussed. This study demonstrates that proteomic tools are valuable in studying stem cell differentiation and elucidating the underlying molecular mechanisms.
Molecular Genetics of Sarcoidosis (2012)

Abstract Sarcoidosis is a systemic inflammatory disorder characterised by the presence of noncaseating granulomas. The aetiology of sarcoidosis remains unknown. Although any organ system can be involved, the common cause of morbidity and mortality occurs from involvement of the lung, heart and nervous system. There has been extensive research, directed on the identification of candidate genes (both HLA and non‐HLA) that lead to dysregulation of the T‐cell response in sarcoidosis. However, most of these reported associations between these genes and susceptibility to sarcoidosis have not been replicated. Advances in genomics and proteomics, in concert with emerging technologies, are expected to provide further insight into pathogenesis and disease risk. Key Concepts: Sarcoidosis is a systemic inflammatory disorder characterised by the presence of noncaseating granulomas of unknown aetiology. Studies have revealed many candidate genes (both HLA and non‐HLA) that lead to dysregulation of the T‐cell response in sarcoidosis. A new strategy is to subgroup patients into distinct clinical phenotypes to help identify genes of importance for the disease. Gene expression profiling in BAL fluid and blood performed at the time of presentation may help to better predict disease resolution or progression. Advances in genomics and proteomics, in concert with emerging technologies, are expected to provide further insight into pathogenesis and disease risk.
Graphene Oxide‐Based Electrode Inks for 3D‐Printed Lithium‐Ion Batteries (2016)

All-component 3D-printed lithium-ion batteries are fabricated by printing graphene-oxide-based composite inks and solid-state gel polymer electrolyte. An entirely 3D-printed full cell features a high electrode mass loading of 18 mg cm(-2) , which is normalized to the overall area of the battery. This all-component printing can be extended to the fabrication of multidimensional/multiscale complex-structures of more energy-storage devices.
Identification of power distribution network topology via voltage correlation analysis (2013)

We consider the problem of reconstructing the topology of a portion of the power distribution network, given a dataset of voltage measurements. By using an approximate model for the grid voltage magnitudes, we show that these signals exhibit some specific correlation properties, that can be described via a sparse Markov random field. By specializing the tools available for the identification of graphical models, we propose an algorithm for the reconstruction of the grid topology. Via simulations, we show how the algorithm performs well also when an exact nonlinear model of the grid voltages is adopted, when realistic power demand profiles are considered, and when the voltage measurements are affected by measurement noise.
Event-related functional magnetic resonance imaging in Parkinson's disease before and after levodopa (2001)

Event-related functional MRI (fMRI) was used to study blood oxygen level dependent cortical signal changes associated with volitional limb movements off and on levodopa in Parkinson's disease. Eight patients with early stage akinetic Parkinson's disease and eight healthy volunteers underwent three functional imaging runs (high speed echo planar imaging with 600 scans/run) while performing paced single joystick movements in a freely chosen direction every 7-15 s. The non-magnetic joystick was linked to a monitoring system for on-line registration of performance parameters along with timing of the pacing tones and fMRI-scan acquisition parameters. This allowed correlation of movement onset, i.e. event-onset, to scanning time. We repeated the scanning procedure in the Parkinson's disease patients when akinesia improved 30 min after oral levodopa. Compared with the control group, patients both off and on levodopa showed movement-related impaired activation in the rostral supplementary motor area and increased activation in primary motor cortex (M1) and the lateral premotor cortex bilaterally. Levodopa led to a relative normalization of the impaired activation in the mesial premotor cortex and decreased signal levels in M1, lateral premotor and superior parietal cortex. We conclude that levodopa improves impaired motor initiation in the supplementary motor area and decreases hyperfunction of lateral premotor and M1 associated with Parkinson's disease during simple volitional movements.