gebhart/patrepeval huggingface dataset:
Excited-state properties of platinum(II) complexes containing biphenyl as a ligand: complexes of the type [(bph)PtL2], where L = monodentate or saturated bidentate ligands (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExcited-state properties of platinum(II) complexes containing biphenyl as a ligand: complexes of the type [(bph)PtL2], where L = monodentate or saturated bidentate ligandsCharles B. Blanton, Zakir Murtaza, Randy J. Shaver, and D. Paul RillemaCite this: Inorg. Chem. 1992, 31, 15, 3230–3235Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/ic00041a012https://doi.org/10.1021/ic00041a012research-articleACS PublicationsRequest reuse permissionsArticle Views531Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mechanisms of immunoregulation. Immunoregulation by antibody and antigen-antibody complexes. (1978)

Biologically important regulatory mechanisms exist in many immune responses. The anatomic characteristics of lymphoid tissues and the cell-collaborative events exhibited in immune responses may be explicable in terms of potent regulatory phenomena rather than or as well as requirements for the initial activation of an immune response by antigen. Mechanistically, the regulatory web54 may be a series of Fc portion attachments to Fc receptors directed by the variable region specificities of the antibodies involved.
A distributed genetic algorithm for multivariable fuzzy control (1993)

The traditional approach to multiple parameter optimization in genetic algorithm (GA) practice is to combine the coding of the parameters into a single compound bit-string; the so-called concatenated binary mapping. This approach has some shortcomings; the GA is a competition-based technique that has a natural tendency to evolve one winner which in complex problems yields a solution that is better on some parameters than the others. An extension to the simple GA, called vector evaluated genetic algorithm (VEGA), has been used in multiobjective optimization where one is not interested in a single solution, but a family of optimal solutions. In VEGA each member of the population is evaluated and assigned a weighted fitness value dependent on how it relates to each objective criteria. The reproduction plan then develops groupings within the populations for each of the objectives to be optimized, ensuring that the improvement of one objective does not adversely affect the others. This, however, requires large population sizes and can be quite inefficient. In cases where the complex task is divisible into simpler optimization problems, a better solution set may be obtained using parallel genetic algorithms to search for the optimal solution to each sub-problem.<
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Novel microbial screen for detection of 1,4-butanediol, ethylene glycol, and adipic acid (1985)

A novel microbial-screening procedure was developed for separate detection of 1,4-butanediol, ethylene glycol, and adipic acid, three commercially important oxychemicals potentially derivable from bacterial omega-oxidation of n-butanol, ethanol, and hexanoic acid, respectively. The screening method involved postproduction addition of one of several specific Pseudomonas strains which produce a soluble fluorescent pigment during growth on the product of interest. A mutation and selection procedure was developed for isolation of specific strains with phenotypes for growth and pigment production on the desired product (e.g., 1,4-butanediol), but not on its bioconversion substrate (e.g., n-butanol), common by-products (e.g., n-butyrate), or product isomers. Pigment production was growth associated and required cultivation of the screening strains under limiting Fe3+ concentrations. The pigments resembled well-characterized, iron-chelating siderophores produced by other fluorescent pseudomonads. The sensitivity of the assay for product accumulation was enhanced by (i) conducting the screening in microtiter dishes to permit examination of individual isolates of putative producers and to control product diffusion, (ii) using a wavelength cutoff filter to reduce background source light, and (iii) using adapted screening strains which grew at lower (0.3 mM) concentrations of test compounds. The potential utility of the method for detecting a variety of oxidative catabolic products is discussed.
Enhancement of Oral Bioavailability and Pharmacological Effect of 1-(3,4-Dimethoxyphenyl)-2,3-bis(methoxycarbonyl)-4-hydroxy-6,7,8-trimethoxynaphthalene (TA-7552), a New Hypocholesterolemic Agent, by Micronization in Co-ground Mixture with D-Mannitol. (1996)

To improve the bioavailability of the sparingly water-soluble drug, 1-(3,4-dimethoxyphenyl)-2,3-bis(methoxycarbonyl)-4-hydroxy-6,7,8- trimethoxynaphthalene (TA-7552), the usefulness of the co-grinding method with D-mannitol was investigated. The co-grinding was performed at various weight ratios of TA-7552 and D-mannitol using a ball mill. The particle size was markedly reduced with increasing amount of D-mannitol. A mixture ratio greater than or equal to 1:3 of the drug and D-mannitol produced submicron-sized particles. In dogs, bioavailability increased with increasing amount of D-mannitol. The 1:9 co-ground mixture gave complete absorption, as did a lecithin solution of the drug. Even co-ground powders with lower amounts of D-mannitol provided relatively high bioavailability in comparison with ground drug powder alone of a similar particle size. Further, pharmacological examination using rats indicated that the inhibition of cholesterol absorption was intestified with the reduction of particle size. These findings suggest that the co-grinding method with D-mannitol is useful for enhancing the bioavailability and pharmacological effectiveness of this sparingly water-soluble drug.
UL34, the target of the herpes simplex virus U(S)3 protein kinase, is a membrane protein which in its unphosphorylated state associates with novel phosphoproteins (1992)

Previous studies (F. C. Purves, D. Spector, and B. Roizman, J. Virol. 65:5757-5764, 1991) have shown that the protein kinase encoded by the U(S)3 gene mediates posttranslational modification of a viral phosphoprotein with an apparent M(r) of 30,000 encoded by the UL34 gene. Here we report the following. (i) UL34 protein is not phosphorylated in cells infected with recombinant viruses deleted in the U(S)3 gene. (ii) Several new phosphoproteins (apparent M(r)s, 25,000 to 35,000) are present in cells infected with recombinant viruses deleted in the U(S)3 gene or with viruses carrying a mutation in the UL34 gene that precluded phosphorylation of the UL34 gene product by the U(S)3 protein kinase, but not in cells infected under conditions which permit phosphorylation of the UL34 protein. These proteins are genetically unrelated to the product of the UL34 gene. (iii) Polyclonal rabbit anti-UL34 protein serum precipitated not only the UL34 protein but also the other (25,000- to 35,000-M(r)) phosphoproteins from lysates of cells infected with U(S)3- virus. (iv) The UL34 gene product is a membrane protein inasmuch as the polyclonal anti-UL34 serum reacted with surfaces of intact, unfixed, infected cells and the antigen-antibody complex formed in this reaction contained the UL34 protein. (v) Small amounts of the UL34 protein were present in virions of infected cells. We conclude that the UL34 gene product is a membrane protein exclusively phosphorylated by the U(S)3 protein kinase which can either directly or indirectly form complexes with several other phosphoproteins. Experiments done thus far suggest that these phosphoproteins are present only under conditions in which the UL34 protein is not phosphorylated.
Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule (2017)

Rac small GTPases and their GEFs of the DOCK family are pivotal checkpoints in development, autoimmunity and bone homeostasis, and their abnormal regulation is associated to diverse pathologies. Small molecules that inhibit their activities are therefore needed to investigate their functions. Here, we characterized the mechanism of inhibition of human DOCK5 by C21, a small molecule that inhibits mouse Dock5 in cells and blocks bone degradation in mice models of osteoporosis. We showed that the catalytic DHR2 domain of DOCK5 has a high basal GEF activity in the absence of membranes which is not regulated by a simple feedback loop. C21 blocks this activity in a non-competitive manner and is specific for DOCK5. In contrast, another Dock inhibitor, CPYPP, inhibits both DOCK5 and an unrelated GEF, Trio. To gain insight into structural features of the inhibitory mechanism of C21, we used SAXS analysis of DOCK5<sup>DHR2</sup> and crystallographic analysis of unbound Rac1-GDP. Together, these data suggest that C21 takes advantage of intramolecular dynamics of DOCK5 and Rac1 to remodel the complex into an unproductive conformation. Based on this allosteric mechanism, we propose that diversion of intramolecular dynamics is a potent mechanism for the inhibition of multidomain regulators of small GTPases.
Is another mannose receptor-like lectin present in retinal pigment epithelium? (1999)

With these techniques, these data demonstrate that the sPLA2 receptor is undetectable in the RPE.
Signal separation in the Wigner distribution domain using fractional Fourier transform (2011)

In this paper we propose an algorithm based on the fractional Fourier transform to separate the different components of a signal in the Wigner time-frequency domain. The aim is to obtain a compressed representation for such a signal containing a minimal number of parameters. The proposed procedure gets rid of the noise and the cross-terms after separating the signal components. Assuming the signals under consideration have chirps and sinusoids, the fractional Fourier transform is used to rotate the components to obtain a sinusoidal or impulsive sparse representation. The procedure relies on filtering or windowing after obtaining the order of the fractional Fourier transform for each of the components. Simulation results show the effectiveness of this approach in extracting the linear chirps and sinusoids from the noise and in eliminating the cross-terms from the Wigner distribution.
Concept-based analysis of scientific literature (2013)

This paper studies the importance of identifying and categorizing scientific concepts as a way to achieve a deeper understanding of the research literature of a scientific community. To reach this goal, we propose an unsupervised bootstrapping algorithm for identifying and categorizing mentions of concepts. We then propose a new clustering algorithm that uses citations' context as a way to cluster the extracted mentions into coherent concepts. Our evaluation of the algorithms against gold standards shows significant improvement over state-of-the-art results. More importantly, we analyze the computational linguistic literature using the proposed algorithms and show four different ways to summarize and understand the research community which are difficult to obtain using existing techniques.
Managing the chip design database (1983)

A design data management system bridges the gap between design tools and database systems, creating an integrated tool environment. Although design databases have long been of interest, they have been largely ignored within the context of the new tools. Our purpose is to describe what design data management is and how it can integrate design tools. Our discussion focuses on unique data management requirements of design systems and conventional database facilities and their shortcomings for supporting design data. We also present the architecture of a prototype design management system in which designs are organized into a richly interconnected data structure, using an object data model. The structures of that system's storage, recovery, concurrency control, and design validation subsystems are also described as is a "browser" for interactively viewing design data.
Desulfurization of Petroleum Coke (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesulfurization of Petroleum CokeSigmund J. Lukasiewicz and George C. JohnsonCite this: Ind. Eng. Chem. 1960, 52, 8, 675–677Publication Date (Print):August 1, 1960Publication History Published online1 May 2002Published inissue 1 August 1960https://pubs.acs.org/doi/10.1021/ie50608a025https://doi.org/10.1021/ie50608a025research-articleACS PublicationsRequest reuse permissionsArticle Views164Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Follow-up of healthy donors receiving granulocyte colony-stimulating factor for peripheral blood progenitor cell mobilization and collection. Results of the Spanish Donor Registry (2008)

The clinical side effects of granulocyte colony-stimulating factor administration in healthy donors are generally mild. Changes in blood counts were minimal and mainly affected white blood cell counts, which returned to normal values within 2 years after granulocyte-colony stimulating factor administration. No patient developed a hematologic malignancy. A larger number of donors and longer follow-up are needed to determine the safety of granulocyte colony-stimulating factor administration definitively.
Historiese grondslae van swart verstedeliking in Suid-Afrika (1988)

(1987). Historiese Grondslae van Swart Verstedeliking in Suid-Afrika. South African Historical Journal: Vol. 19, No. 1, pp. 7-29.
Coronavirus Disease-19 Infection: Implications on Male Fertility and Reproduction (2020)

The pandemic caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has led to several concerns on male fertility. Nowadays, there are numerous unanswered questions, for example: is the virus present or not in the seminal fluid of infected subjects? Could the seminal fluid represent a way of sexual transmission for the virus? Why do men appear to be more susceptible than women? Several studies have been carried out to ascertain the presence of SARS-CoV-2 in the seminal fluid, with contrasting results; the expression of angiotensin-converting enzyme-2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in the testes and in the male genital tract led to speculation about the possible presence of the virus in the seminal fluid. However, it was found that ACE2 and TMPRSS2, used by the virus to enter host cells, are expressed differently in certain testicle cells (stem germ cells, Leydig and Sertoli cells), yet the testicle cells in which ACE2 and TMPRSS2 molecules are simultaneously expressed are rare. This fact would suggest that the virus is not able to enter testicular cells, that it is not present in the seminal fluid and that it cannot infect male germ cells. However, the direct influence of SARS-CoV-2 on the testes is still to be evaluated, and recent results are very controversial. SARS-CoV-2 could enter the testicle using alternative paths and lead to alterations in testicular functionality. Another plausible consideration is that the COVID-19 disease could also indirectly cause alterations to testicular activity, since the fever and the cytokinic storm generated by the immune system can lead to damage of the testicular activity, consequently compromising male fertility. Although the literature provides controversial evidence, the purpose of this review is to lend a general overview about the state of the art. Despite the lack of studies, it would represent a starting point for further investigation about the effect of this coronavirus on male fertility.
Speech intelligibility estimation using multi-resolution spectral features for speakers undergoing cancer treatment (2014)

Head and neck cancer can significantly hamper speech production which often reduces speech intelligibility. A method of extracting spectral features is presented. The method uses a multi-resolution sinusoidal transform scheme, which enables better representation of spectral and harmonic characteristics. Regression methods were used to predict interval-scaled intelligibility scores of utterances in the NKI-CCRT speech corpus. The inclusion of these features lowered the mean squared estimation error from 0.43 to 0.39 on a scale from 1 to 7, with a p-value less than 0.001. For binary intelligibility classification, their inclusion resulted in an improvement by 5.0 percentage points when tested on a disjoint set.
Generative Adversarial Networks for Open Set Historical Chinese Character Recognition (2018)

Historical Chinese character recognition has been suffering from the problem of samples labeling, not only the problem of lacking sufficient labeled training samples, but also of sample classes. So the scenario for Historical Chinese character recognition is "open set" recognition, where incomplete labeling of sample classes is present at training time, and unknown classes can be submitted to the system during testing. This paper proposes a method for open set Historical Chinese Character Recognition. For open set recognition, the features available in the training data cannot effectively characterize different kinds of unknown classes. We assume that the features which characterize unknown classes can be derived or learned from other similar data sets. We utilize an auxiliary data set combined with the open set training data set to learn good features to represent historical Chinese characters. The auxiliary data set is translated using Generative Adversarial Networks (GAN) to make sure that the translated data set is as close to the historical Chinese character dataset as possible. Then we construct a neural network for features extraction. The neural network is trained using an alternative training method with the translated auxiliary dataset and incomplete labeled historical Chinese character data set. Last, features are extracted from certain layer of the trained neural network. Unknown samples are detected using statistical modelling of the Euclidean metric between samples. Experimental results show that the proposed method is effective.
A suitable power transfer control system for interconnection converter of DC microgrids (2008)

The operation and control strategies for interconnection of DC microgrids have not been studied in previous researches. In this paper, an electrical model has been developed for DC microgrids and a suitable control system has been proposed for a DC/DC converter connecting two DC microgrids. Simulation results indicate the effectiveness of the proposed control strategy in power flow control and the cancellation of interactions between two DC microgrids.
Flexible spatial models for grouping local image features (2004)

A key step for the effective use of local image features (i.e., highly distinctive and robust features) for recognition or image matching is the appropriate grouping of feature matches. Spatial constraints are important in this grouping because, during a recognition process, they allow for the reduction of the number of hypotheses that must be verified and also reduce the number of false positives present in each of these hypotheses. A common choice for this grouping task is to use the Hough transform on the global spatial transformation parameters of the hypothesized matches. Here, instead, we use semi-local spatial constraints which allow for a greater range of shape deformations. A comparison with Hough transform shows that our method is more robust to both rigid and non-rigid deformations. Its functionality is demonstrated in an exemplar-based object recognition system that deals well with severe non-rigid deformations. We also show the efficacy of our flexible spatial grouping far long range motion problems.
Plasmid selection in Escherichia coli using an endogenous essential gene marker (2008)

The fabI-triclosan model system provides an alternative plasmid selection method based on essential gene over-expression, without the use of antibiotic-resistance genes and conventional antibiotics.
Differential Effect of Time Perspective on Global Superiority (2019)

본 연구에서는 편향된 시간조망에서의 시각적 주의범위 차이를 알아보기 위하여 일련의 실험을 수행하였다. 527명의 참가자에게 시간조망검사를 실시하여 미래지향 시간조망과 현재쾌락 시간조망 간의 부적 상관을 토대로 각 집단의 극단점수에 해당하는 편향된 시간조망을 가진 참가자 20명씩을 선별하였다. 선별된 두 집단의 참가자들을 대상으로 자극유형과 자극-자극 자질 일치 여부가 체계적으로 조작된 실험조건에서 전역우월성 효과를 측정하였다. 실험결과, 자극의 유형(복합도형과 복합문자)과 편향된 시간조망 집단과의 전역우월성 효과에서 상호작용이 나타났으며, 복합문자의 전역우월성 효과에서 편향된 시간조망 집단 간의 유의한 차이가 있었다. 즉, 편향된 미래지향 시간조망 집단은 복합문자 자극에서 전역우월성 효과가 크게 나타났다. 또한 자극-자극 자질 일치 여부와 편향된 시간조망 집단과의 상호작용이 있었는데, 자극-자극 자질 불일치 조건의 경우에 편향된 시간조망 집단 간의 전역우월성 효과 차이가 유의한 것으로 나타났다. 이는 편향된 미래지향 시간조망 집단이 자극-자극 자질이 불일치한 경우에서 전역우월성 효과가 크게 나타났음을 확인할 수 있다. 이러한 결과를 종합해 볼 때, 편향된 미래지향 시간조망을 가진 개인들은 편향된 현재쾌락 시간조망의 개인들에 비해 더 큰 전역우월성 효과가 나타남을 알 수 있으며 이는 편향된 시간조망에 따라 시각적 주의범위가 달라질 수 있음을 시사한다.
Triplet Exciplexes in the Photochemistry of Quinones (1987)

The results of studies on the kinetics and mechanisms of reactions involving the transfer of an electron and a hydrogen atom to quinone molecules in triplet states are surveyed and the spectroscopic-kinetic characteristics of the triplet exciplexes of quinones and the role of the electron donor–acceptor interactions and hydrogen-bonded complexes in the photochemistry of quinonoid compounds are examined. Attention is concentrated on the experimental investigation of the kinetics and mechanisms of the primary photochemical processes by modern flash photolysis methods. The bibliography includes 276 references.
Novel scheme for disparity estimation based on variable feature primitive (2008)

Disparity estimation is a crucial issue in stereoscopic and multi view video processing.In this paper,a novel scheme for disparity estimation is proposed.The scheme selects variable line segment as feature primitive.The uniqueness constraint and ordering constraint are employed to enhance the accuracy of disparity estimation.The principle of the new scheme is analyzed and experiments are implemented.Experimental results reveal that the proposed algorithm can acquire reliable,sub precise and dense disparity fields and it outperforms the traditional FSBM,VSBM algorithms.