gebhart/patrepeval huggingface dataset:
Robust LPV control for vehicle steerability and lateral stability (2014)

This paper presents an integrated control of the steering and braking subsystems to improve vehicle handling and directional stability. During normal driving situations (from low to mid-range lateral acceleration), the proposed controller serves as steerability (driveability) controller involving only active front steering. The control objective in this driving zone is to enhance the vehicle steering response by tracking a reference yaw rate. However, when the vehicle reaches the handling limits, the developed controller is used as a stability controller collaborating both active front steering and rear braking. The primary objective becomes to stabilize the vehicle while reducing the vehicle sideslip motion. The proposed MIMO controller, called VDMC (Vehicle Dynamics Management and Control), is synthesized within the gain scheduled LPV framework allowing the selection of the variable to be controlled (yaw rate/sideslip angle) and the coordination of steering/braking actuators according to the vehicle driving conditions. VDMC is built by the solution of an LMI problem, while warranting H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> robust performances. Simulation results carried out on a full nonlinear vehicle model confirm the effectiveness of the developed control system and the overall improvements in vehicle handling and directional stability.
Transaction Monitoring in Networks on Chip: The On-Chip Run-Time Perspective (2006)

Networks-on-chip (NoC) are a scalable interconnect solution to multiprocessor systems on chip (MPSoC). NoCs transport data in packets which are fragments of transactions, such as read and write actions of IPs. For debug purposes, reconstructing transactions at run-time is essential. Run-time analysis of the NoC behavior at transaction level makes the complete MPSoC easier to understand. We present a NoC analyzer able to monitor NoC transactions at run-time. The proposed hardware transaction monitor is able to reconstruct on-chip, at run-time, NoC transactions from bit-level intercepted router link communication. Four NoC analyzer modes are detailed raising the abstraction level gradually from physical raw to logical connection-based, transaction-based and abstract transaction event-based. Each mode is analyzed for area and bandwidth in an experimental setup based on several AEligthereal NoC designs. A transaction monitor has an area cost of 0.026 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> in a 0.13 mum CMOS technology, and for several MPEG/audio case studies, the entire monitoring system adds an average of 5% to the NoC area. We show the versatility of our NoC analyzer by run-time monitoring user connections and the Configuration Master IP in the NoC.
Down-regulation and Phosphorylation of Glucocorticoid Receptors in Cultured Cells (1989)

The expression of the glucocorticoid receptor (GR) gene and the phosphorylation of the GR protein has been studied as a function of time after hormone addition to NIH 3T3 cells. We detected a ligand-induced decrease of GR gene expression at both the level of RNA and protein. GR mRNA declined to 25% of the control within 3 h of dexamethasone treatment and remained at this level for at least 24 h. GR protein was analyzed with a monospecific antiserum directed against the DNA- and hormone-binding domains of the rat GR synthesized in Escherichia coli. Pulse-chase experiments revealed a decrease in GR half-life from 8 h in the absence of hormone to 3 h following hormone treatment. Both effects resulted in a reduction of total GR protein to 20% as determined by quantitative immunoblotting. The level of the GR protein returned to that of untreated cells within 24 h after withdrawal of hormone. Furthermore, dexamethasone treatment led to a 3-4-fold increase in GR phosphorylation within 60 min. The glucocorticoid antagonist 17 beta-hydroxy-11 beta-(4-dimethylamino-phenyl)-17 alpha-(1-propynyl)-oestra-4,9-dien-3-one (RU 486) did not change the phosphorylation state of the receptor, but a down-regulation of the GR was still observed. These results suggest that ligand-dependent receptor phosphorylation is not involved in down-regulation of the GR but may be important in the transcriptional activation of hormone responsive genes.
Population history and its impact on medical genetics in Quebec (2005)

Knowledge of the genetic demography of Quebec is useful for gene mapping, diagnosis, treatment, community genetics and public health. The French-Canadian population of Quebec, currently about 6 million people, descends from about 8500 French settlers who arrived in Nouvelle-France between 1608 and 1759. The migrations of those settlers and their descendants led to a series of regional founder effects, reflected in the geographical distribution of genetic diseases in Quebec. This review describes elements of population history and clinical genetics pertinent to the treatment of French Canadians and other population groups from Quebec and summarizes the cardinal features of over 30 conditions reported in French Canadians. Some were discovered in French Canadians, such as autosomal recessive ataxia of the Charlevoix-Saguenay (MIM 270550), agenesis of corpus callosum and peripheral neuropathy (MIM 218000) and French-Canadian-type Leigh syndrome (MIM 220111). Other conditions are particularly frequent or have special genetic characteristics in French Canadians, including oculopharyngeal muscular dystrophy, hepatorenal tyrosinaemia, cystic fibrosis, Leber hereditary optic neuropathy and familial hypercholesterolaemia. Three genetic diseases of Quebec First Nations children are also discussed: Cree encephalitis (MIM 608505), Cree leukoencephalopathy (MIM 603896) and North American Indian childhood cirrhosis (MIM 604901).
Surface Current Density Mapping for Identification of Gastric Slow Wave Propagation (2009)

The magnetogastrogram (MGG) records clinically relevant parameters of the electrical slow wave of the stomach noninvasively. Besides slow wave frequency, gastric slow wave propagation velocity is a potentially useful clinical indicator of the state of health of gastric tissue, but it is a difficult parameter to determine from noninvasive bioelectric or biomagnetic measurements. We present a method for computing the surface current density from multichannel MGG recordings that allows computation of the propagation velocity of the gastric slow wave. A moving dipole source model with hypothetical as well as realistic biomagnetometer parameters demonstrates that while a relatively sparse array of magnetometer sensors is sufficient to compute a single average propagation velocity, more detailed information about spatial variations in propagation velocity requires higher density magnetometer arrays. Finally, the method is validated with simultaneous MGG and serosal electromyography measurements in a porcine subject.
Drug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (2001)

Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) is an inclusive term describing diverse syndromes of multiple etiologies with the common features of thrombocytopenia and microangiopathic hemolytic anemia. Other organ involvement, including renal failure, neurologic abnormalities, and gastrointestinal symptoms, is common. Adverse reactions to drugs increasingly are reported as a potential cause of TTP-HUS. More than 50 drugs and other substances have been associated with the development of TTP-HUS, but many case reports are difficult to interpret because there is uncertainty regarding the diagnosis of TTP-HUS and because there is uncertainty regarding the relation of drug exposure to the onset of TTP-HUS. A systematic analysis of reports of drug-associated TTP-HUS will be required to better understand the strength of clinical evidence linking drugs to the etiology of TTP-HUS. In this review, five drugs that have been the subject of the most and the most recent reports of drug-associated TTP-HUS are discussed: mitomycin C, cyclosporine, quinine, ticlopidine, and clopidogrel. The clinical features of TTP-HUS associated with these drugs are different, suggesting two principal mechanisms by which drugs may cause TTP-HUS: dose-related toxicity (mitomycin C, cyclosporine), and immune-mediated reaction (quinine, ticlopidine, clopidogrel). The role of plasma exchange is uncertain, but this treatment is appropriate because of the high mortality and morbidity of drug-associated TTP-HUS. Recognition of a drug-associated etiology in a patient with TTP-HUS is critical to avoid re-exposure and recurrent illness.
Computer-aided assessment in mathematics: Panacea or propaganda? (2012)

The proponents of computer-aided assessment are very persuasive in extolling the benefits and virtues of this technology. Undoubtedly, it has many positive features. However, it also has some limitations and drawbacks which need to be considered. Mathematics as a discipline has certain specific problems which are not relevant to the use of computer-aided assessment in many other disciplines. These problems often feature the introduction of the assessment of other learning outcomes into the process. This can create problems in summative assessment but is less of a problem in formative assessment. Evidence is supplied that students find the use of computer-aided assessment in a formative manner to be worthwhile. Finally, a key question about the future development of computer-aided assessment in mathematics is posed.
Hormonal status and fluid electrolyte metabolism in motion sickness. (1988)

In the first experimental series, 10 healthy male test subjects with a high susceptibility to motion sickness showed a significant increase of ACTH, cortisol, STH, prolactin, ADH, aldosterone concentrations, and plasma renin activity after vestibular tests. The 10 subjects with a moderate susceptibility exhibited a still higher increase of the hormones, except plasma renin. The 8 test subjects with a low susceptibility displayed a considerable increase in ACTH, cortisol, and STH after vestibular stimulation. In the second experimental series, the increase of STH, cortisol, ADH, aldosterone and renin occurred immediately after rotation in the moderate susceptibility subjects and an hour after exposure in the high susceptibility subjects. This may be indicative of specific immediate adaptation mechanisms or excitation transfer in the CNS in high susceptibility persons. In the third experimental animal series, the permeability of the blood-brain barrier for 125I and IgG increased after rotation. Greater concentrations of potassium, chloride, and urea in CSF are suggestive of an inhibition process activation in the CNS and, probably, of an active urea transport by the vascular plexus epithelium which maintains constant osmotic pressure of cerebral extracellular fluid and prevents hyper-hydration of CNS neurons.
Sex disparities in use of chemotherapy and survival in patients with advanced bladder cancer (2016)

Women are less likely than men to receive systemic chemotherapy for advanced bladder cancer and this difference may partially account for the poorer OS observed in women. However, OS remains lower in women independent of chemotherapy use, and may be related to unmeasured comorbidities, functional status, or tumor biology. Cancer 2016;122:2012-20. © 2016 American Cancer Society.
Lithiation–Borylation Methodology and Its Application in Synthesis (2014)

Developing new methods that enable the synthesis of new and complex molecules with complete control of their 3-D shape is central to the advancement of synthetic chemistry with applications spanning from medicine to materials. Our approach consists of the iterative combination of small building blocks through the use of boron chemistry to essentially "grow" molecules. This approach, which we term assembly-line synthesis (ALS), resembles the way that nature assembles natural products (e.g., the polyketide synthase machinery) and has the advantage that many structural variations can be easily introduced and the products can be evaluated in structural or biological contexts. Chiral boronic esters have been recognized as valuable building blocks due to their unique chemical properties. They are both chemically and configurationally stable, and they can be prepared with very high levels of enantioselectivity. Additionally they undergo a broad array of transformations that lead to the stereocontrolled formation of C-C and C-X (X = heteroatom) bonds. This versatility makes boronic acids ideal building blocks for iterative molecular assembly. A powerful reaction platform for chemical diversification using chiral boronic esters is their homologation using lithium carbenoids via 1,2-metalate rearrangement. In the 1980s, Matteson described the use of boronic esters bearing a chiral diol in a two-step homologation process with dichloromethyl lithium and Grignard reagents (substrate-controlled approach). We have focused on reagent control and have found that Hoppe's chiral lithiated carbamates can be used as carbenoid equivalents in conjunction with achiral boronic esters. This reagent-controlled process offers many advantages due to the easy access of both the chiral lithiated carbamates and stable boronic esters. The carbamates can be derived from primary or secondary alcohols, and a broad range of functionalized boronic esters and boranes can be employed. Multiple homologations can be carried out in a one-pot sequence thereby streamlining the process to a single operation. This methodology has enabled the synthesis of many molecules containing multiple contiguous stereogenic centers with exquisite 3-D control. In this Account, we trace our own studies to establish the lithiation-borylation methodology and describe selected synthetic applications.
Presence of human papillomavirus type 16 related sequences in verrucous carcinoma of the larynx. (1986)

Verrucous carcinoma of the larynx clinically resembles laryngeal papilloma in that both are wart-like masses on the vocal cords and may be characterized by multifocality and recurrence. Human papillomavirus (HPV) infection is an etiological factor in laryngeal papilloma, and recent evidence implicates HPV in squamous neoplasias. To determine whether HPV is also associated with verrucous carcinoma of the larynx, we analyzed tissue specimens from six patients with verrucous carcinoma of the larynx by Southern and DNA dot blot hybridization for HPV DNA. From three patients, specimens of normal laryngeal epithelium were also studied. All tissues showed evidence of HPV sequences related but not identical to HPV-16. They were negative for HPV-11. In contrast, four squamous cell carcinomas of the larynx and three normal laryngeal tissues were negative for HPV DNA. Histological sections of the six verrucous lesions were found to contain koilocytosis. Immunoperoxidase staining for HPV capsid antigens was negative in all these cases. The consistent and specific association of HPV with the verrucous carcinomas in this report suggests the possibility of a pathogenic involvement.
Study on Authentication for Live Streaming Media over P2P-Based Network (2009)

The purpose of this article is to discuss an authentication method for peer to peer (P2P)-based streaming media. Methods of encryption of streaming media data and digital signatures were used to improve the safety of the media. The digital certificate publishing service and management services of live streaming media authentication information are expanded in the live stream system based on P2P networks. Besides, software used in client are extended functions such as application of digital certificates, decryption of the media stream, request for certification in order to be used by the client to the provider of live stream. The live stream was received from P2P-based network, decrypted and played by the client. The security of media has been improved and the protection for live media copyright has been enhanced through this way.
Biocomposites of Nanofibrillated Cellulose, Polypyrrole, and Silver Nanoparticles with Electroconductive and Antimicrobial Properties (2014)

In this work, flexible and free-standing composite films of nanofibrillated cellulose/polypyrrole (NFC/PPy) and NFC/PPy-silver nanoparticles (NFC/PPy-Ag) have been synthesized for the first time via in situ one-step chemical polymerization and applied in potential biomedical applications. Incorporation of NFC into PPy significantly improved its film formation ability resulting in composite materials with good mechanical and electrical properties. It is shown that the NFC/PPy-Ag composite films have strong inhibition effect against the growth of Gram-positive bacteria, e.g., Staphylococcus aureus. The electrical conductivity and strong antimicrobial activity makes it possible to use the silver composites in various applications aimed at biomedical treatments and diagnostics. Additionally, we report here the structural and morphological characterization of the composite materials with Fourier-transform infrared spectroscopy, atomic force microscopy, and scanning and transmission electron microscopy techniques.
An integrated microfluidic biochemical detection system with magnetic bead-based sampling and analysis capabilities (2002)

This paper presents the development and characterization of an integrated microfluidic biochemical detection system for fast and low volume immunoassays using magnetic beads, which are used as both immobilization surfaces and bio-molecule carriers. Magnetic bead-based immunoassay, as a typical example of biochemical detection and analysis, has been successfully performed on the integrated microfluidic biochemical analysis system that includes a surface-mounted biofilter and immunosensor on a glass microfluidic motherboard. Total time required for full immunoassay was less than 20 minutes including sample incubation time and sample volume wasted was less than 50 /spl mu/l during five repeated assays. Fast and low volume biochemical analysis has been successfully achieved with the developed biofilter and immunosensor, which is integrated to microfluidic system.
Electrochemical Synthesis of Beta- and Gamma-Manganese Dioxides under Hydrothermal Conditions (2001)

The hydrothermal-electrochemical method has been used for the synthesis of manganese dioxides from acidic solutions. This method produced manganese dioxides of either the β- or γ-structure type. At pH 1 and 130°C, pure was formed; this was the first time that this structure has been obtained electrochemically. At 113 or 92°C, mixtures of β- and were obtained, and the content decreased with temperature. Increasing the acidity at 92°C led to the formation of pure with lower levels of pyrolusite intergrowth and microtwinning defects compared to prepared by traditional electrochemical syntheses. © 2001 The Electrochemical Society. All rights reserved.
TRANSIMS IS COMING (2000)

TRANSIMS is a series of integrated transportation and air quality analysis and forecasting models being developed at the Los Alamos National Laboratory. The principal components of TRANSIMS are an activity generator, an intermodal route planner, a traffic microsimulation, and an environmental analysis module. TRANSIMS will offer transportation planning agencies increased policy sensitivity, more detailed vehicle-emission estimates, and improved analysis and visualization capabilities. TRANSIMS is part of the Travel Model Improvement Program (TMIP), a multiyear, multiagency program designed to improve both the analytical tools and the integration of these tools into the planning process. TRANSIMS is the long-term effort to redesign the modeling process from the ground up. The modules developed for TRANSIMS contain many significant advances beyond the four-step models: disaggregate models, simulation, integrated system, highly detailed vehicle emission estimates, and operational tools. The development of TRANSIMS' core capabilities is complete; however, a case study, set in Portland, Oregon, will explore the sensitivity of TRANSIMS software to different types of data.
Self-assembly and magnetic properties of cobalt nanoparticles (2003)

Two- and three-dimensional superlattices of passivated cobalt nanoparticles were formed by a self-assembly technique. The size and stabilization of the cobalt nanoparticles are controlled by using the combination of oleic acid and triphenylphosphine. The cobalt nanoparticles are stable for at least 90 days without oxidation at room temperature under ambient conditions. The magnetic properties of the cobalt nanoparticles in different forms are compared, which provides helpful information on the magnetostatic interaction of the nanoparticles.
The hydrogen sulphide‐releasing derivative of diclofenac protects against ischaemia–reperfusion injury in the isolated rabbit heart (2007)

These data show that S-diclofenac had marked anti-ischaemic activity in ischaemic-reperfused rabbit hearts despite inhibition of prostaglandin generation. Increased GSH formation leading to activation of K(ATP) channels may have contributed to this beneficial effect. The pharmacological profile of S-diclofenac and its anti-inflammatory activity, with diminished gastrointestinal side effects, offer therapeutic applications in cardiovascular disease.
MALDI‐TOF Mass Spectrometric Analysis of Enzyme Activity and Lectin Trapping on an Array of N‐Glycans (2011)

Active arrays: Complex lipid-tagged oligosaccharides, including large multiantennary species, can be efficiently immobilized on self-assembled monolayers of alkyl mercaptans (see picture). These arrays can be used to follow the action of a galactosyltransferase (GalT) and a hydrolase. The utility of the system for the selective trapping and identification of a lectin from a complex mixture was also demonstrated.
Microprocessor Self-Testing for Mine Monitor Systems (1985)

Microprocessor reliability in coal mine monitoring applications has become increasingly important in recent years. This has been true not only for the mining industry, but the computer industry as well. Processor maintenance self-diagnostics have been commonly utilized for microcomputer systems. However, in the case of a microprocessor used in a critical monitor/control environment, small memory and little free processing time limits the use of these diagnostics on a continuous basis. In the past, maintenance diagnostics have been very exhaustive for minicomputer systems and execution time can be quite long. These were primarily used on an infrequent aperiodic basis by a maintenance technician. Normal system diagnostic tests are generally run at time of power up, and the system becomes operational only after successful completion. If diagnostic tests could occur automatically without user interference, such as when the system is not being heavily utilized, it is possible that failures could be found more quickly and without cata-strophic system failure. Solutions to these problems are presented as applied to a distributed microprocessor system used for testing mine monitor/control systems. A set of self-test algorithms for an 8085-based microprocessor is presented. Tests are performed on the CPU, ROM, RAM, 8251A USART, A/D, and D/A converters, and an 8253A interval timer. These self-test algorithms are not exhaustive but have been found to provide an adequate test of microprocessor validity on power up. Similar tests could and should be used on any underground monitor/control system as a minimum test.