gebhart/patrepeval huggingface dataset:
Transmission of organic molecules by a silicone membrane gas chromatograph/mass spectrometer interface (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransmission of organic molecules by a silicone membrane gas chromatograph/mass spectrometer interfaceCasper C. Greenwalt, Kent J. Voorhees, and Jean H. FutrellCite this: Anal. Chem. 1983, 55, 3, 468–472Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://pubs.acs.org/doi/10.1021/ac00254a014https://doi.org/10.1021/ac00254a014research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Polarization analyzer for vacuum uv and x radiation (1976)

A simple analyzer is described for the determination of the degree of polarization of vacuum uv and x rays. The analyzer uses solar blind detectors and, thus, is ideal for use in circumstances where visible and near-uv radiation is present in addition to the radiation under investigation.
ChemInform Abstract: New Aspects of Hypervalent Tellurium Compounds (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
BTF‐CIELab: A Perceptual Difference Measure for Quality Assessment and Compression of BTFs (2009)

Abstract Driven by the advances in lossy compression of bidirectional texture functions (BTFs), there is a growing need for reliable methods to numerically measure the visual quality of the various compressed representations. Based on the CIE Δ E 00 colour difference equation and concepts of its spatio‐temporal extension ST‐CIELab for video quality assessment, this paper presents a numerical quality measure for compressed BTF representations. By analysing the BTF in its full six‐dimensional (6D) space, light and view transition effects are integrated into the measure. In addition to the compressed representation, the method only requires the source BTF images as input and thus aids the objective evaluation of different compression techniques by means of a simple numerical comparison. By separating the spatial and angular components of the difference measure and linearizing each of them, the measure can be incorporated into any linear or multi‐linear compression technique. Using a per‐colour‐channel principal component analysis (PCA), compression rates of about 500:1 can be achieved at excellent visual quality.
Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid (2008)

The data presented here suggest that the engineered yeast producing artemisinic acid suffers oxidative and drug-associated stresses. The use of plant-derived transporters and optimizing AMO activity may improve the yield of artemisinic acid production in the engineered yeast.
Entropy-Constrained Spike Modulus Quantization In A Bio-Inspired Universal Audio Coder (2008)

Publication in the conference proceedings of EUSIPCO, Lausanne, Switzerland, 2008
CD48 Binds to Heparan Sulfate on the Surface of Epithelial Cells (1998)

CD48 is a member of the immunoglobulin superfamily whose cell surface expression is strikingly up-regulated on the surface of Epstein-Barr virus-infected B cells. To date, no ligand for human CD48 has been characterized. In this study, we show that human recombinant CD48 binds to the glycosaminoglycan heparan sulfate on the surface of human epithelial cells. We have produced a monoclonal antibody (615) against epithelial cell surfaces that blocks this binding and show that it too recognizes heparan sulfate. The specific epitope on heparan sulfate that is recognized by the antibody and is involved in binding is also expressed in vivo on the basolateral surfaces of mucosal epithelium and lamina propria.
A working formulation for the standardization of nomenclature and for clinical staging of chronic dysfunction in lung allografts. International Society for Heart and Lung Transplantation. (1993)

A clinically applicable, standardized method for assessing functional results after lung transplantation is required to evaluate factors that may affect long-term outcome, to permit comparison of results from different centers, and to evaluate results of clinical trials. An ad hoc working group was established under the auspices of the International Society for Heart and Lung Transplantation for the purpose of developing such a clinically applicable system. Chronic allograft dysfunction is often associated with pathologic findings of obliterative bronchiolitis, the cause of which has not been defined. Physiologically, such dysfunction is associated with obstructive airways disease. The group concluded that the forced expiratory volume in 1 second was the most reliable and consistent indicator of graft dysfunction, excluding other identifiable causes. The term bronchiolitis obliterans syndrome was adopted to describe such dysfunction, recognizing that there may or may not be pathologic evidence of bronchiolitis obliterans present. Four stages of bronchiolitis obliterans syndrome were defined, each with two subcategories to indicate whether pathologic evidence of obliterative bronchiolitis had been identified. This working formulation will require reappraisal in the future to reassess its practical application and to make such adjustments as may seem appropriate.
The PEP-II Project-Wide Database (2002)

The PEP-II Project Database is a tool for monitoring the technical and documentation aspects of this accelerator construction. It holds the PEP-II design specifications, fabrication and installation data in one integrated system. Key pieces of the database include the machine parameter list, magnet and vacuum fabrication data, CAD drawings, publications and documentation, survey and alignment data, and property control. The database can be extended to contain information required for the operations phase of the accelerator and detector. Features such as viewing CAD drawing graphics from the database will be implemented in the future. This central Oracle database on a UNIX server is built using Oracle*Case tools. Users at the three collaborating laboratories (SLAC, LBL, LLNL) can access the data remotely, using various desktop computer platforms and graphical interfaces.
Membership authentication in dynamic face groups (2003)

Presents a method to authenticate an individual's membership in a group without revealing the individual's identity and without restricting how the member of the group may be changed. It has the ability to authenticate membership and is robust to cope with the variations of both the group size and the group member of membership.
Discrete-time nonlinear system identification using recurrent neural networks (2004)

In this paper we proposed a novel discrete-time recurrent neural networks. Input-to-state stability (ISS) approach is applied to access robust training algorithms. We conclude that for discrete-time nonlinear system identification, the gradient descent law and the backpropagation-like algorithm for the weights adjustment are stable in the sense of L/sub /spl infin// and robust to any bounded uncertainties.
Modulating Membrane Composition Alters Free Fatty Acid Tolerance in Escherichia coli (2013)

Microbial synthesis of free fatty acids (FFA) is a promising strategy for converting renewable sugars to advanced biofuels and oleochemicals. Unfortunately, FFA production negatively impacts membrane integrity and cell viability in Escherichia coli, the dominant host in which FFA production has been studied. These negative effects provide a selective pressure against FFA production that could lead to genetic instability at industrial scale. In prior work, an engineered E. coli strain harboring an expression plasmid for the Umbellularia californica acyl-acyl carrier protein (ACP) thioesterase was shown to have highly elevated levels of unsaturated fatty acids in the cell membrane. The change in membrane content was hypothesized to be one underlying cause of the negative physiological effects associated with FFA production. In this work, a connection between the regulator of unsaturated fatty acid biosynthesis in E. coli, FabR, thioesterase expression, and unsaturated membrane content was established. A strategy for restoring normal membrane saturation levels and increasing tolerance towards endogenous production of FFAs was implemented by modulating acyl-ACP pools with a second thioesterase (from Geobacillus sp. Y412MC10) that primarily targets medium chain length, unsaturated acyl-ACPs. The strategy succeeded in restoring membrane content and improving viability in FFA producing E. coli while maintaining FFA titers. However, the restored fitness did not increase FFA productivity, indicating the existence of additional metabolic or regulatory barriers.
Oxa1p, an essential component of the N-tail protein export machinery in mitochondria (1998)

A number of nuclear encoded inner membrane proteins of mitochondria span the membrane in such a manner that their N termini are located in the intermembrane space. Many of these proteins attain this membrane orientation by undergoing an export step from the matrix across the inner membrane. This export process, which resembles bacterial N-tail export from energetic and topogenic signal requirements, is facilitated by Oxa1p, a protein that has homologues throughout prokaryotes and eukaryotes. Oxa1p, as we have previously shown, is required to export the N and C termini of the mitochondrially encoded pCoxII to the intermembrane space. We demonstrate here that imported nuclear encoded proteins physically interact with Oxa1p and depend on Oxa1p for efficient export of their N termini to the intermembrane space. Furthermore, Oxa1p interacts with nascent polypeptide chains synthesized in mitochondria, including the fully synthesized pCoxII and CoxIII species. Thus, Oxa1p represents a component of a general export machinery of the mitochondrial inner membrane.
Synthesis and characterization of divalent ion conductors with NASICON-type structures (2019)

Divalent ion-conducting solid electrolytes with NASICON-type three-dimensional network structures (MxHf1−x)4/(4−2x)Nb(PO4)3 (M = Ni, Mg, Ca, Sr) were successfully developed by introducing M2+ cations into HfNb(PO4)3 solids. The presence of high-valence cations such as Hf4+, Nb5+, and P5+ in the structures effectively reduced the electrostatic interaction between the conducting M2+ cations and the surrounding oxide anions, enabling the M2+ cations to migrate smoothly in the rigid crystal lattice. The relationship between the cation conductivity in NASICON-type solids and the ionic radius of the migrating divalent cation species was also clarified by taking into account the relative sizes of the conduction pathways in the structures.
Current Density Dependence for Dark-Line Defect Growth Velocity in Strained InGaAs / AlGaAs Quantum Well Laser Diodes (1991)

Dark-line defects (DLDs) of threading dislocation origin in strained InGaAs/AlGaAs quantum well laser diodes were observed by the electron-beam induced current technique. Current density dependence for the DLD growth velocity was compared quantitatively with that for unstrained GaAs/AlGaAs quantum well laser diodes for the first time. The <110>DLD growth velocity in InGaAs QW laser diodes is estimated to be about 1/100 of that for the <100>DLD growth in the GaAs QW laser diodes, showing linear dependence on injected current densities.
Synthesis and Evaluation of Pregnane Derivatives as Inhibitors of Human Testicular 17α-Hydroxylase/C<sub>17,20</sub>-Lyase<sup>,</sup> (1996)

The pregnene derivatives with modifications at the 17,20-side chain and D-ring were synthesized and evaluated as inhibitors of human testicular 17 alpha-hydroxylase/C17,20-lyase. The results demonstrate that compounds which have 20-substituents with moderate to strong dipole properties, such as 20-oxime (3, 20), 20 beta-ol (24, 30), and 20 beta-carboxaldehyde (27), are potent inhibitors of this enzyme complex. The 20-substituents with hydrophobic property were devoid of inhibitory activity, e.g., the dimethylhydrazones 8 and 9. The 16-ene together with 20-oxime (20) showed the most potent inhibition of this enzyme complex, whereas 17(20)-ene modification as in 17(20)-ene-20-carbonitrile (14) did not increase activity in comparison to the 20 beta-carbonitrile (16). The bioisotere of 27 with 20-aza (19) also reduced the inhibitory activity. The results showed that isomeric configurations at the 20-position of some steroidal compounds are important factors which influence the potency of the inhibition significantly (e.g., 20 beta-ols 24 and 30 were 3-5-fold more potent than 20 alpha-ols 23 and 29). As expected, some compounds based on the pregn-5-en-3 beta-ol skeleton, which is similar to the natural substrate of human testicular 17 alpha-hydroxylase/C17,20-lyase in A- and B-rings, showed more potent inhibition than similar compounds which are based on the pregn-4-en-3-one skeleton (e.g., 23-25 compared to 29-31). These results suggest that A- and B-rings make significant contributions to the binding of these steroidal compounds to the 17 alpha-hydroxylase and C17,20-lyase. In comparison to ketoconazole, a nonsteroidal inhibitor of 17 alpha-hydroxylase and C17,20-lyase which has been used in the treatment of prostatic cancer, the steroidal compounds 20, 24, and 27 demonstrate more potent inhibition for this enzyme complex. These inhibitors warrant further investigation in biological systems. The structural features of these compounds may serve as leads in the design of new inhibitors.
Analysis of the Economic Disaster Scale for Fog Case occurred at the Incheon International Airport (2007)

Poor visibility is very important information in aviation meteorology factor, because secure safety, trust and economical efficiency increase for aircraft movements. The Incheon International Airport 4 years recent times was to period aircraft movements delay and cancellation due to meteorology is 52% and 30%. And then fog is 63% and 43% in meteorology factor. Therefore, the analysis against the economic loss size of an airline due to the fog is necessary. This study is indirectly estimated economic disaster scale of flight return and cancellation due to the fog in the Incheon International Airport from 5 to 6 March 2006. This is based on an aviation operational statistics data and meteorology observation data. Result of estimated, total 14 flights return to Gimpo, Jeju and Gimhae in this period are about 208,205,700 won. And estimated total 10 flights cancellation are about 718,657,000 won.
Endo‐lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease? (2016)

Alzheimer's disease (AD) is the most common cause of dementia, and its prevalence will increase significantly in the coming decades. Although important progress has been made, fundamental pathogenic mechanisms as well as most hereditary contributions to the sporadic form of the disease remain unknown. In this review, we examine the now substantial links between AD pathogenesis and lysosomal biology. The lysosome hydrolyses and processes cargo delivered by multiple pathways, including endocytosis and autophagy. The endo-lysosomal and autophagic networks are central to clearance of cellular macromolecules, which is important given there is a deficit in clearance of amyloid-β in AD. Numerous studies show prominent lysosomal dysfunction in AD, including perturbed trafficking of lysosomal enzymes and accumulation of the same substrates that accumulate in lysosomal storage disorders. Examination of the brain in lysosomal storage disorders shows the accumulation of amyloid precursor protein metabolites, which further links lysosomal dysfunction with AD. This and other evidence leads us to hypothesise that genetic variation in lysosomal genes modifies the disease course of sporadic AD.
Dysphagia Following Brain-Stem Stroke (1991)

We studied 23 individuals (16 men, seven women; mean age 57 years) who had brainstem strokes confirmed by computed tomography of the head or magnetic resonance imaging. Videofluoroscopic modified barium-swallowing examination showed aspiration in 15 of 23 patients. Of the 15 aspirating patients, the majority had bilateral strokes with multiple lesion loci, most often in association with large-vessel disease. All 15 patients had involvement of the pons or medulla. Statistical analyses revealed a significant association between aspiration and pharyngeal residue observed under videofluoroscopy, cranial nerve IX abnormality, vocal fold weakness, and severe dysarthria. Despite initial severity, recovery was good. Following an aggressive program of aspiration prevention, over 80% of patients resumed full oral nutrition at the last follow-up.
Secure resource description framework (2006)

In this paper we propose an access control model for the Resource Description Framework (RDF). We argue that existing access control models, like the ones developed for securing eXtensible Markup Language (XML) documents, do not provide sufficient protection for RDF data. Our security model incorporates RDF and RDF Schema (RDFS) entailments. RDF protection objects are represented as RDF-patterns that are mapped to RDF and RDFS statements to determine their security requirements. We develop methods to assign security classification to entailed statements and to detect unauthorized inferences. We propose a two-level conflict resolution strategy. Simple conflict resolution addresses the problem when more than one pattern can be mapped to the same RDF statement, resulting in conflicting classification. Inference conflict resolution addresses inconsistencies that occur due to entailment.
AIST-NREL Concentrator Photovoltaic (CPV) Demonstration. Cooperative Research and Development Final Report, CRADA Number CRD-10-402 (2015)

The purpose of the project is to demonstrate and quantitatively compare performance of CPV systems installed in Japan and in the United States. The deployment conditions (e.g. spectrum and temperature) are site dependent and the optimal design of the system may vary with location. The CPV systems will use multi-junction concentrator cells for the conversion of sunlight into electricity. The optimal design of the cell may depend on the location at which a CPV system is installed. Thus, the systems in Japan and in the U.S. will all use a combination of concentrator cells obtained from three different vendors. This CRADA pertains only to the equipment that will be installed in the U.S. This effort is a collaborative project between AIST and NREL.
TFF peptides in the human efferent tear ducts. (2002)

The epithelium of the nasolacrimal ducts synthesizes TFF3 and in some cases also TFF1. In contrast to the human conjunctiva, in which TFF3 is detectable only in goblet cells, TFF3 of the lacrimal sac and nasolacrimal duct is produced in large amounts by epithelial cells as well as by serous glands, but not-or in small amounts only-by goblet cells. This is comparable with localization of TFF3 in the major salivary glands. Thus, TFF3 may have a special function in tear transport through the lacrimal passage comparable to its function on the ocular surface, because the peptide, together with TFF1, may contribute to the rheologic properties of the tear film. Moreover, the TFF peptides may also influence epithelial healing with their motogenic properties.
Cellular responses to chronic treatment with drugs of abuse. (1993)

This review focuses on the long-term adaptations opiates and cocaine induce in specific regions of the nervous system that underlie the additive actions of the drugs, and the mechanisms by which such adaptations are achieved. To date, opiate and cocaine regulation of post-receptor, intracellular messenger pathways has shed considerable light on the mechanisms underlying chronic drug action. Of particular interest is the up-regulation of the cyclic AMP pathway observed in the locus coeruleus (LC), a brain region involved in physical opiate addition, in response to chronic opiate administration. Up-regulation of the cyclic AMP pathway has been shown to contribute to the opiate tolerance, dependence, and withdrawal exhibited by these neurons electrophysiologically. A similar up-regulation of the cyclic AMP pathway in response to chronic opiate and chronic cocaine treatments has been observed in the mesolimbic dopamine system, which is implicated in the psychological aspects of drug addiction. Several lines of evidence suggest the possibility that these biochemical adaptations may contribute to opiate and cocaine regulation of this neural pathway. Related studies in inbred rat strains raise the additional possibility that similar adaptations may contribute to individual genetic vulnerability to drug addition. Current studies are aimed at investigating opiate and cocaine regulation of transcription factors in these discrete brain regions to identify the molecular mechanisms involved in drug action. The investigations have focused on the Fos-Jun family of immediate early gene transcription factors, and the CREB family of transcription factors, as possible mediators of the effects of chronic opiate and cocaine exposure on regulation of neuronal gene expression. Ultimately, more direct analyses are needed that make use of methods for detecting changes in target gene expression in vivo. Together, these studies of opiate and cocaine action will help define the precise mechanisms, at the molecular level, by which these drugs of abuse alter the expression of specific genes in particular neuronal cell types and thereby produce physical and psychological aspects of drug addition.
Syntheses and properties of polyureas from divalent metal salts of <i>p</i>‐aminobenzoic acid, diamine, and diisocyanate (1990)

Abstract Metal‐containing polyureas having ionic links in the main chain were synthesized by the polyaddition reactions of 2,4‐toluylene diisocyanate with mixtures of divalent metal salts of p ‐aminobenzoic acid and 4,4′‐diaminodiphenylmethane (4,4′‐methylenedianiline). Mg and Ca were used as the divalent metal. The polyureas obtained were slightly yellowish powders and those with low metal content were soluble in dimethylacetamide (DMAc) and dimethylsulfoxide (DMSO). The inherent viscosity (at 0.5 g/100 mL) of the polyureas decreased markedly with an increase in metal content. In addition, the reduced viscosities in DMAc and DMSO were very low at very low concentration but became higher as the concentration increased, especially in DMAc having a somewhat lower dielectric constant. This viscosity increase at high concentrations is attributed to ionic association. Introducing the metal into the polyurea lowered the thermal properties as indicated by decreased decomposition temperatures. The polyureas with low metal contents gave films by solvent‐casting although increasing the metal content made the films brittle. Further, dynamic mechanical properties were discussed.