gebhart/patrepeval huggingface dataset:
Journal of Experimental Psychology: Applied. Instructions to authors. (2002)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Performance of fiber-optic data links using 670-nm cw VCSELs and a monolithic Si photodetector and CMOS preamplifier (1995)

To be competitive with copper technology for links and bus applications, optoelectronics must be made affordable. One means of achieving a low-cost optoelectronics link is to adapt volume-manufactured components. This may imply CMOS optoelectronic integrated circuits (OEICs), which are suggested by the huge CMOS IC volumes being produced for computer logic and memory, and red laser diodes, which are already in demand for the consumer and storage markets. In this paper, we demonstrate a potential low-cost link using a monolithically integrated Si photodiode and CMOS preamplifier, a multimode fiber-optic transmission medium, and red, vertical-cavity surface-emitting lasers (VCSELs). The integrated receiver shows a 3.5-dB improvement in received power when light at 670 nm instead of 845 nm is used; it operates error free at both the Fibre Channel rate of 531.25 Mb/s and the SONET OC-12 rate of 622.08 Mb/s. The red VCSELs are shown to be capable of a 1.5-Gb/s transmission data rate with as little as 18 mW average power dissipation. The potential for fabricating arrays using both of these technologies for optical buses is discussed.
Alzheimer’s disease, dementia, and stem cell therapy (2017)

Alzheimer's disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuitry by exogenous stem cells is therefore a rational therapeutic strategy. This review will focus on recent advances in stem cell therapies utilizing animal models of AD, as well as detailing the human clinical trials of stem cell therapies for AD that are currently undergoing development.
Primary prevention of Down's syndrome (2005)

Background: Antenatal screening has the capacity to detect more than 90% of Down's syndrome pregnancies leading to therapeutic abortion. Successes in recent years with such so-called 'secondary' prevention have not been matched with progress in primary prevention. Despite considerable research over many decades the principle cause of the disorder is unknown. Methods: This paper considers three potential primary prevention strategies, (1) avoiding reproduction at advanced maternal age, (2) pre-implantation genetic diagnosis for couples who are at high risk of Down's syndrome, and (3) folic acid supplementation. The principle aetiological hypotheses are also reviewed. Interpretation: A strategy of completing the family before a maternal age of 30 could more than halve the birth prevalence of this disorder. Women with a high a priori risk should have access to pre-implantation genetic diagnosis, which can lead to a reasonably high pregnancy rate with an extremely low risk of a Down's syndrome. The evidence suggesting an aetiological role for defective folate and methyl metabolism is not sufficient to justify an active preventative strategy of folic acid supplementation without performing a large clinical trial. Current supplementation policies designed to prevent neural tube defects may incidentally prevent Down's syndrome, provided a sufficiently high dose of folic acid is used. Further progress in primary prevention is hampered by limited aetiological knowledge and there is an urgent need to refocus research in that direction.
A probe detector for defectivity assessment in p-n junctions (2000)

In this paper, we present a process probe capable of measuring the avalanche ignition rate of the generation centers, in order to investigate some process-dependent morphological properties of p-n junctions. In particular, we report a nonlinear dependence of the defectivity with the area of circular junctions, which can be ascribed to a radially growing density of generation centers, like dopant clusters. This hypothesis has been verified by means of both microscopic inspection of the probes and comparison with alternative probe geometries. Technological hints are finally provided to counteract the defectivity, thus leading to potential improvements in the fabrication of microelectronic devices.
Multi-Dimensional Range Query over Encrypted Data (2007)

We design an encryption scheme called Multi-dimensional Range Query over Encrypted Data (MRQED), to address the privacy concerns related to the sharing of network audit logs and various other applications. Our scheme allows a network gateway to encrypt summaries of network flows before submitting them to an untrusted repository. When network intrusions are suspected, an authority can release a key to an auditor, allowing the auditor to decrypt flows whose attributes (e.g., source and destination addresses, port numbers, etc.) fall within specific ranges. However, the privacy of all irrelevant flows are still preserved. We formally define the security for MRQED and prove the security of our construction under the decision bilinear Diffie-Hellman and decision linear assumptions in certain bilinear groups. We study the practical performance of our construction in the context of network audit logs. Apart from network audit logs, our scheme also has interesting applications for financial audit logs, medical privacy, untrusted remote storage, etc. In particular, we show that MRQED implies a solution to its dual problem, which enables investors to trade stocks through a broker in a privacypreserving manner.
A novel decentralized time slot allocation algorithm in dynamic TDD system (2006)

This paper proposes the decentralized time slot allocation (DTSA) algorithm in dynamic TDD (DTDD) system to support traffic asymmetry. In D-TDD systems, additional interferences are introduced when one cell is uplink (downlink) and the other cell is downlink (uplink). These kinds of interferences result in severe performance degradation of SIR, which occurs especially to users in cell edge than users in cell center. To reduce additional interferences, DTSA algorithm is applied to D-TDD system. This algorithm assumes decentralized cellular network, so, it operates independently in each cell and has lower complexity than the other systems. Using DTSA algorithm, the outage probability of uplink and downlink at 0dB are decreased about 4.3% and 8.5% compared to conventional D-TDD system, respectively. Also DTSA algorithm increases the system capacity compared to S-TDD system and conventional D-TDD system. Simulation results show that D-TDD system with DTSA algorithm can support more asymmetric traffic than other systems, which increase system capacity.
Self-rectifying and forming-free unipolar HfO<inf>x</inf> based-high performance RRAM built by fab-avaialbe materials (2011)

In this paper, we report a high performance, forming-free and self-rectifying unipolar HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> based RRAM fabricated by fab-available materials. Highlight of the demonstrated RRAM include 1) CMOS technology friendly materials and process, 2) excellent self-rectifying behavior in LRS (>;10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> @ 1 V), 3) forming-free unipolar resistive switching, 4) wide read-out margin for high density cross-point memory devices (number of word-line >;10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> for worst case condition).
Purification, Cloning, and Expression of Murine Uridine Phosphorylase (1995)

Uridine phosphorylase was purified 10,300-fold from tumors of the murine colorectal adenocarcinoma cell line, Colon-26. Degenerate DNA probes were synthesized corresponding to partial amino acid sequences and used to screen a Colon-26 cDNA library. A cDNA clone of 1327 base pairs that contains a 5' untranslated region, a coding region of 933 base pairs, and a 3' nontranslated region with a polyadenylated tail was identified. The cDNA was confirmed to be uridine phosphorylase by 1) sequence comparison to uridine phosphorylase of Escherichia coli, 2) substrate specificity studies with recombinant protein expressed in COS-7 cells that demonstrated relatively high enzyme activity with uridine as substrate compared low levels when thymidine was used, and 3) inhibition of enzyme activity by the competitive inhibitor 2,2'-anhydro-5-ethyluridine. Northern blot analysis using the cDNA as a probe, demonstrated high levels of mRNA expression in Colon-26. Expression was low in NIH3T3 cells, but high in DMBA-3 and PH-1 cells, which are NIH3T3-derived cells that have been transformed with mutated murine Ha-ras and viral Ha-ras, respectively. Expression of uridine phosphorylase mRNA in these cell lines was further enhanced by treating the cells with the inflammatory cytokines, tumor necrosis factor-alpha, interleukin 1 alpha, and interferon gamma.
Quantitative measurement of small‐angle gamma ray scattering from water, nylon, and Lucite (1989)

The small-angle (2 degrees-10 degrees) total-differential-scattering cross sections of water, methyl methacrylate, and nylon 6 have been measured at a photon energy of 59.54 keV. An annular target geometry has been used with an acceptance of +/- 0.5 degrees and an experimental uncertainty of approximately 4% achieved. The experimental methods and data corrections necessary to obtain this accuracy are discussed in detail. The results demonstrate clearly the contribution of intermolecular effects to the scattering process and allow critical comparison with calculations using molecular form factors for water obtained from interpolated x-ray diffractometer data; agreement is obtained within the experimental uncertainties. They also support earlier Monte Carlo predictions of scattering in water at angles of the order of 2 degrees which are in disagreement with certain published experimental data.
Predictive maneuver evaluation for enhancement of Car-to-X mobility data (2012)

Advanced Driver Assistance Systems (ADAS) employ single object information to provide safety, comfort, or infotainment features. The required data is mainly extracted from external sensors to recognize and predict the future states of relevant traffic participants. Next generation ADAS will also use data from additional sources like, e.g., Car-to-X communication networks, to avoid some typical restrictions of common sensor setups. In this work, we present a method, which uses information on other traffic participants, and furthermore recognizes and considers their interactions in terms of traffic maneuvers to better predict their states. For this purpose, a probabilistic framework is presented, which recognizes object interactions as well as different road characteristics by introducing local, adaptive occupancy grids. The resulting maneuver recognition is shown to considerably improve received mobility data in terms of position, speed, and heading. These concepts have been fully implemented and evaluated by means of real world experiments.
Direct and Fast Ray Tracing of NURBS Surfaces (2006)

Recently it has been shown that Bezier surfaces can be used as a geometric primitive for interactive ray tracing on a single commodity PC. However, the Bezier representation is restricted, as a large number of control points also imply a high polynomial degree, thus reducing the frame rate significantly. In this work we present a fast, efficient and robust algorithm to ray trace trimmed NURBS surfaces of arbitrary degree. Furthermore, our approach is largely independent of the number of control points of a surface with respect to the rendering performance. Additionally the degree and the number of control points of a surface do not influence the numerical stability of the intersection algorithm. The desired high performance is achieved by taking a novel approach of surface evaluation, which requires only minimal preprocessing. We present a method to transform the computationally expensive Cox-de Boor recursion into a SIMD suitable form that maximizes performance by avoiding the recursion and drastically reduces the number of executed commands
Self-Organized Periodicity of Protein Clusters in Growing Bacteria (2008)

Chemotaxis receptors in E. coli form clusters at the cell poles and also laterally along the cell body, and this clustering plays an important role in signal transduction. Recently, experiments using fluorescence imaging have shown that, during cell growth, lateral clusters form at positions approximately periodically spaced along the cell body. In this Letter, we demonstrate within a lattice model that such spatial organization could arise spontaneously from a stochastic nucleation mechanism. The same mechanism may explain the recent observation of periodic aggregates of misfolded proteins in E. coli.
Generalization of Gassmann equations for porous media saturated with a solid material (2007)

Abstract Gassmann equations predict effective elastic properties of an isotropic homogeneous bulk rock frame filled with a fluid. This theory has been generalized for an anisotropic porous frame by Brown and Korringa's equations. Here, we develop a new model for effective elastic properties of porous rocks — a generalization of Brown and Korringa's and Gassmann equations for a solid infill of the pore space. We derive the elastic tensor of a solid-saturated porous rock considering small deformations of the rock skeleton and the pore infill material upon loading them with the confining and pore-space stresses. In the case of isotropic material, the solution reduces to two generalized Gassmann equations for the bulk and shear moduli. The applicability of the new model is tested by independent numerical simulations performed on the microscale by finite-difference and finite-element methods. The results show very good agreement between the new theory and the numerical simulations. The generalized Gass-mann model introduces a new heuristic parameter, characterizing the elastic properties of average deformation of the pore-filling solid material. In many cases, these elastic moduli can be substituted by the elastic parameters of the infill grain material. They can also represent a proper viscoelastic model of the pore-filling material. Knowledge of the effective elastic properties for such a situation is required, for example, when predicting seismic velocities in some heavy oil reservoirs, where a highly viscous material fills the pores. The classical Gassmann fluid substitution is inapplicable for a configuration in which the fluid behaves as a quasi-solid.
Long-term Outcome for Large Meniscal Defects Treated with Small Intestinal Submucosa in a Dog Model (2005)

Small intestinal submucosa implants might be useful for treatment of large posterior vascular meniscal defects in humans.
A New Measure of Travel Time Reliability for In-Vehicle Navigation Systems (2008)

This article introduces a new measure of travel time reliability for implementation in the dynamic routing algorithm of an intelligent car navigation system. The measure is based on the log-normal distribution of travel time on a link and consists of two indices corresponding to the extreme values of the distribution, such that they reflect the shortest and longest travel times that may be experienced on the link. Through a series of mathematical manipulations, the indices are expressed in terms of the characteristic values of the speed distribution on the link. An expression relating the indices of a route and the indices of the individual links forming it is derived. The accuracy of the measure is then assessed through a field experiment and the results are presented.
Bacteria used in the biological control of plant-parasitic nematodes: populations, mechanisms of action, and future prospects (2007)

As a group of important natural enemies of nematode pests, nematophagous bacteria exhibit diverse modes of action: these include parasitizing; producing toxins, antibiotics, or enzymes; competing for nutrients; inducing systemic resistance of plants; and promoting plant health. They act synergistically on nematodes through the direct suppression of nematodes, promoting plant growth, and facilitating the rhizosphere colonization and activity of microbial antagonists. This review details the nematophagous bacteria known to date, including parasitic bacteria, opportunistic parasitic bacteria, rhizobacteria, Cry protein-forming bacteria, endophytic bacteria and symbiotic bacteria. We focus on recent research developments concerning their pathogenic mechanisms at the biochemical and molecular levels. Increased understanding of the molecular basis of the various pathogenic mechanisms of the nematophagous bacteria could potentially enhance their value as effective biological control agents. We also review a number of molecular biological approaches currently used in the study of bacterial pathogenesis in nematodes. We discuss their merits, limitations and potential uses.
Measurement of magnetic field from radio-frequency identification antenna for use in operation room (2017)

Retaining of surgical instruments in the patient's bodies has occasionally happened. To prevent it, surgical instruments with radio-frequency identification tags and new antenna for use in an operation room (ORAnt) were developed. With the use of such surgical instruments can be identified automatically during surgery. The system should precisely recognize the surgical instruments and not to interfere with work of intraoperative medical equipment. The purpose of this study was measurement of the magnetic field distribution of ORAnt. It revealed that with increase of the distance in z-axis direction, the magnetic field strength attenuated to the −4th powers of the distance.
Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population (2011)

We recently reported the results of a genome-wide association study (GWAS) of schizophrenia in the Japanese population. In that study, a single nucleotide polymorphism (SNP) (rs3106653) in the KCNJ3 (potassium inwardly rectifying channel, subfamily J, member 3) gene located at 2q24.1 showed association with schizophrenia in two independent sample sets. KCNJ3, also termed GIRK1 or Kir3.1, is a member of the G protein-activated inwardly rectifying K(+) channel (GIRK) group. GIRKs are widely distributed in the brain and play an important role in regulating neural excitability through the activation of various G protein-coupled receptors. In this study, we set out to examine this association using a different population. We first performed a gene-centric association study of the KCNJ3 gene, by genotyping 38 tagSNPs in the Chinese population. We detected nine SNPs that displayed significant association with schizophrenia (lowest P = 0.0016 for rs3106658, Global significance = 0.036). The initial marker SNP (rs3106653) examined in our prior GWAS in the Japanese population also showed nominally significant association in the Chinese population (P = 0.028). Next, we analyzed transcript levels in the dorsolateral prefrontal cortex of postmortem brains from patients with schizophrenia and bipolar disorder and from healthy controls, using real-time quantitative RT-PCR. We found significantly lower KCNJ3 expression in postmortem brains from schizophrenic and bipolar patients compared with controls. These data suggest that the KCNJ3 gene is genetically associated with schizophrenia in Asian populations and add further evidence to the "channelopathy theory of psychiatric illnesses".
RETRACTED: Anti-Cancer Activities of Thyrointegrin αvβ3 Antagonist Mono- and Bis-Triazole Tetraiodothyroacetic Acid Conjugated via Polyethylene Glycols in Glioblastoma (2021)

Integrin αvβ3 receptors are overexpressed in different tumors and their associated neovascularization and hence, represent a potential cancer target. We previously synthesized a high affinity thyrointegrin αvβ3, P<sub>4000</sub>-bi-TAT (tetrac derivative), with potent anticancer properties. However, the long polydisperse PEG conjugate showed large scaleup and analytical/bioanalytical issues. Hence, in the present study, we synthesized a mono versus bi-triazole tetrac with discrete monodisperse PEG, which provided improvement in scaleup and bioanalysis. In the present study, we compared binding affinity and anticancer activates with a smaller PEG size (P<sub>1600</sub>-bi-TAT, Compound <b>2</b>) and the removal of one TAT molecule (P<sub>1600</sub>-m-TAT, Compound <b>3</b>) versus P<sub>4000</sub>-bi-TAT, Compound <b>1</b>. The results of the selectivity and affinity of TATs showed greater affinity to integrin αvβ3. The xenograft weights and tumor cell viabilities were decreased by >90% at all doses compared to the control (ON Treatment, *** <i>p</i> < 0.001) in cells treated with Compounds <b>1</b>, <b>2</b>, and <b>3</b> in U87-Luc-treated mice. The in vivo luminescent signals of U87-luc cells reflect the proliferation and distribution of tumor cells in the animals and the maximum intensity corresponding to the maximum tumor cells that the animals could tolerate. We found that the three thyrointegrin αvβ3 antagonists exhibited optimal therapeutic efficacy against U87 or primary glioblastoma cells. Biological studies showed that decreasing the PEG linker size (1600 vs. 4000) or having mono-TAT or bi-TAT had no significant impact on their αvβ3 binding affinity, anti-angiogenesis, or overall anti-cancer efficacy.
Myocardial Blood Flow in Coronary Artery Disease (1973)

Sixteen patients, 10 with significant three-vessel coronary artery disease (>50% occlusion of each vessel) and six without coronary disease, had nutrient myocardial blood flow, cardiac output, pressure time/min and arterial pressure determinations at rest, with atrial pacing and with right atrial pacing plus nitroglycerin. In the patients with coronary disease, nutrient myocardial blood decreased an average of 16% ( P < 0.001) with pacing alone but increased by 22% ( P < 0.001) from the pacing flows with the addition of 0.4 mg sublingual nitroglycerin at the same pacing rate. The directional changes in myocardial blood flow were unrelated to perfusion pressure or pressure work. In the patients without coronary disease, opposite effects were observed. With right atrial pacing, nutrient myocardial blood flow increased by 23% ( P < 0.02). With the addition of nitroglycerin, myocardial blood flow decreased by 15% ( P < 0.02). These changes were directionally related to changes in pressure-work of the heart It is suggested that the findings in this study are consistent with observations made in the experimental animal which indicate that the effect of nitroglycerin may be partly due to a redistribution of myocardial blood flow.
Factors influencing the intracellular activity of fluoroquinolones: a study using levofloxacin in a Staphylococcus aureus THP-1 monocyte model (2006)

Levofloxacin exhibited substantially lower intracellular activity than extracellular activity. Cellular compartmentalization of the drug, phagolysosomal environment and antibiotic binding to cellular components most likely contribute to this failure.