gebhart/patrepeval huggingface dataset:
The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury (2018)

Idiopathic Pulmonary Fibrosis (IPF) is a chronic lung disease characterized by scar formation and respiratory insufficiency, which progressively leads to death. Pulmonary hypertension (PH) is a common complication of IPF that negatively impacts clinical outcomes, and has been classified as Group III PH. Despite scientific advances, the dismal prognosis of IPF and associated PH remains unchanged, necessitating the search for novel therapeutic strategies. Accumulating evidence suggests that stimulation of the angiotensin II type 2 (AT<sub>2</sub>) receptor confers protection against a host of diseases. In this study, we investigated the therapeutic potential of Compound 21 (C21), a selective AT<sub>2</sub> receptor agonist in the bleomycin model of lung injury. A single intra-tracheal administration of bleomycin (2.5 mg/kg) to 8-week old male Sprague Dawley rats resulted in lung fibrosis and PH. Two experimental protocols were followed: C21 was administered (0.03 mg/kg/day, ip) either immediately (prevention protocol, BCP) or after 3 days (treatment protocol, BCT) of bleomycin-instillation. Echocardiography, hemodynamic, and Fulton's index assessments were performed after 2 weeks of bleomycin-instillation. Lung tissue was processed for gene expression, hydroxyproline content (a marker of collagen deposition), and histological analysis. C21 treatment prevented as well as attenuated the progression of lung fibrosis, and accompanying PH. The beneficial effects of C21 were associated with decreased infiltration of macrophages in the lungs, reduced lung inflammation and diminished pulmonary collagen accumulation. Further, C21 treatment also improved pulmonary pressure, reduced muscularization of the pulmonary vessels and normalized cardiac function in both the experimental protocols. However, there were no major differences in any of the outcomes measured from the two experimental protocols. Collectively, our findings indicate that stimulation of the AT<sub>2</sub> receptor by C21 attenuates bleomycin-induced lung injury and associated cardiopulmonary pathology, which needs to be further explored as a promising approach for the clinical treatment of IPF and Group III PH.
Molecular Aspects of Intestinal Epithelial Cell-bacterial Interactions That Determine the Development of Intestinal Inflammation (2004)

The mechanisms by which intestinal epithelial cells perceive and respond to microbes, both pathogenic and commensal, is important to understand the pathogenesis of inflammatory diseases. Recent work has established that most eukaryotic cells possess families of receptors that can detect the structural signatures of prokaryotic life. Cells respond to the detection of microbes by activation of distinct cytoplasmic signaling cascades that ultimately result in the transcriptional activation of programs of genes with proinflammatory and anti-apoptotic function. These responses generally suffice to eliminate microbial threats. Also important are potential mechanisms by which microbes can influence the intestinal epithelial responses, influences with significant implications for the normal function of the intestine and inflammatory diseases.
Weighted learning of bidirectional associative memories by global minimization (1992)

A weighted learning algorithm for bidirectional associative memories (BAMs) by means of global minimization, where each desired pattern is weighted, is described. According to the cost function that measures the goodness of the BAM, the learning algorithm is formulated as a global minimization problem and solved by a gradient descent rule. The learning approach guarantees not only that each desired pattern is stored as a stable state, but also that the basin of attraction is constructed as large as possible around each desired pattern. The existence of the weights, the asymptotic stability of each desired pattern and its basin of attraction, and the convergence of the proposed learning algorithm are investigated in an analytic way. A large number of computer experiments are reported to demonstrate the efficiency of the learning rule.
Fast Marching Methods (1999)

Fast Marching Methods are numerical schemes for computing solutions to the nonlinear Eikonal equation and related static Hamilton--Jacobi equations. Based on entropy-satisfying upwind schemes and fast sorting techniques, they yield consistent, accurate, and highly efficient algorithms. They are optimal in the sense that the computational complexity of the algorithms is O(N log N), where N is the total number of points in the domain. The schemes are of use in a variety of applications, including problems in shape offsetting, computing distances from complex curves and surfaces, shape-from-shading, photolithographic development, computing first arrivals in seismic travel times, construction of shortest geodesics on surfaces, optimal path planning around obstacles, and visibility and reflection calculations. In this paper, we review the development of these techniques, including the theoretical and numerical underpinnings; provide details of the computational schemes, including higher order versions; and demonstrate the techniques in a collection of different areas.
The effect of sound direction on frequency tuning in mouse inferior collicular neurons. (1999)

This study examined the effect of sound direction on frequency tuning of inferior collicular (IC) neurons of mice under free field stimulation conditions. Fewer than 20% of IC neurons studied were spontaneously active. Discharge patterns can be described as phasic on responders, phasic on-off responders, off responders, choppers and tonic responders. The frequency tuning curves (FTCs) of IC neurons can be described as narrow, intermediate or broad. Although sound direction typically had little effect on most best frequencies (BFs), sharpness of FTCs increased as sound direction changed from contralateral angles to ipsilateral angles. Sound delivered from the upper and lower portions of the frontal auditory space also appeared to produce sharper frequency tuning than from the front. Possible mechanisms underlying this direction dependent frequency tuning are discussed.
A Method to Construct a Third-Generation Horseradish Peroxidase Biosensor:  Self-Assembling Gold Nanoparticles to Three-Dimensional Sol−Gel Network (2002)

A novel method for fabrication of horseradish peroxidase biosensor has been developed by self-assembling gold nanoparticles to a thiol-containing sol-gel network. A cleaned gold electrode was first immersed in a hydrolyzed (3-mercaptopropyl)-trimethoxysilane (MPS) sol-gel solution to assemble three-dimensional silica gel, and then gold nanoparticles were chemisorbed onto the thiol groups of the sol-gel network. Finally, horseradish peroxidase (HRP) was adsorbed onto the surface of the gold nanoparticles. The distribution of gold nanoparticles and HRP was examined by atomic force microscopy (AFM). The immobilized horseradish peroxidase exhibited direct electrochemical behavior toward the reduction of hydrogen peroxide. The performance and factors influencing the performance of the resulting biosensor were studied in detail. The resulting biosensor exhibited fast amperometric response (2.5 s) to H2O2. The detection limit of the biosensor was 2.0 micromol L(-1), and the linear range was from 5.0 micromol L(-1) to 10.0 mmol L(-1). Moreover, the studied biosensor exhibited high sensitivity, good reproducibility, and long-term stability.
Modulation of human deoxycytidine kinase activity as a response to cellular stress induced by NaF. (2001)

Deoxycytidine kinase (dCK) is one of the key enzymes of deoxynucleoside salvage supplying resting lymphocytes with DNA precursors for synthesis and repair. The level of dCK activity is especially important in chemotherapy with the use of deoxynucleoside analogues like arabinosyl cytosine (Citarabid, ara-C), or 2-chloro-deoxyadenosine (Cladribine, CdA). Previous results showed that Cladribine treatment of human lymphocytes increased several fold the activity of dCK without increasing the amount of dCK protein itself (Sasvári-Székely, et al., 1998, Biochem. Pharmacol. 56, 1175), and a possible post-translational modification was suggested. This theory was further investigated using NaF as an inhibitor of protein phosphatases. It was shown that NaF treatment of cells elevated dCK activity while inhibiting DNA synthesis. The possible mechanism of dCK activation/inactivation induced by exposure of cell cultures to different agents is discussed.
Solid-Phase Synthesis of Circular Oligonucleotides (2004)

A protocol for the straightforward preparation of small circular oligodeoxyribonucleotides (2-28 nt) is reported. The assembly of the oligonucleotide chain (standard phosphoramidite chemistry) and cyclization by the phosphotriester method take place on a tailor-made nucleotide-derivatized solid support. Although cyclization yields are moderate, the procedure exploits a synthesis design that allows selective cleavage of the circular oligonucleotide from the support, which facilitates isolation of the target molecule by simple filtration.
Knowledge-Based Bundling of Smart Products on a Mobile Recomendation Agent (2008)

Mobile technologies have the potential to change not only brick-and-mortar stores but also the way, how customers interact with physical products. They enable operational agility by means of improved availability and quality of information required by customers for in-store purchase decisions. In this paper, we show how an in-store bundling scenario can be supported by semantically enriched products (denoted as smart products) that provide dynamic product information through the use of mobile recommendation agents  (MRA). We introduce therefore the concept of knowledge-based bundling that relies on smart products and MRA. In addition, we developed a MRA and evaluated its user acceptance for product bundle purchases. For this purpose, a lab experiment was conducted (n=37), which resulted in some design enhancements and promising adoption rates.
Endogenous survivin modulates survival and proliferation in UVB‐treated human keratinocytes (2009)

Survivin is a bi-functional member of inhibitor of apoptosis protein family, as it is able to both inhibit apoptosis and to regulate cell cycle. We investigated the role of survivin in human keratinocytes under normal conditions and during UVB irradiation. Survivin siRNA decreases proliferation and induces apoptosis in human keratinocytes, in a mode consistent with the mitotic catastrophe. Low doses UVB increase survivin expression at earlier times, while high doses down-regulate survivin level. Low doses UVB induce cell cycle arrest in G2/M, while high doses UVB cause apoptosis. Moreover, overexpression of survivin protects keratinocytes from UVB-induced apoptosis, and silencing of survivin renders keratinocytes more susceptible to UVB-induced cell death. Finally, survivin siRNA increases UVB-induced reduction of cell proliferation. Taken together, these results indicate that survivin plays a critical role in epidermal homeostasis in normal conditions and during UVB exposure, with possible implication in skin carcinogenesis.
Crystal construction and molecular interplay in solid ferrocene, nickelocene, and ruthenocene (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal construction and molecular interplay in solid ferrocene, nickelocene, and ruthenoceneDario Braga and Fabrizia GrepioniCite this: Organometallics 1992, 11, 2, 711–718Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/om00038a032https://doi.org/10.1021/om00038a032research-articleACS PublicationsRequest reuse permissionsArticle Views474Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Fast and reliable droplet transport on single-plate electrowetting on dielectrics using nonfloating switching method (2010)

In a droplet transport based on electrowetting on dielectrics, the parallel-plate configuration is more popular than the single-plate one because the droplet transport becomes increasingly difficult without cover plate. In spite of the improved transport performance, the parallel-plate configuration often limits the access to the peripheral components, requesting the removal of the cover plate, the single-plate configuration. We investigated the fundamental features of droplet transport for the single-plate configuration. We compared the performance of several switching methods with respect to maximum speed of successive transport without failure and suggested nonfloating switching method which is inherently free from the charge-residue problem and exerts greater force on a droplet than conventional switching methods. A simple theory is provided to understand the different results for the switching methods.
Improvasher: A Real-Time Mashup System For Live Musical Input (2014)

In this paper we present Improvasher a real-time musical accompaniment system which creates an automatic mashup to accompany live musical input. Improvasher is built around two music processing modules, the first, a performance following technique, makes beat-synchronous predictions of chroma features from a live musical input. The second, a music mashup system, determines the compatibility between beat-synchronous chromagrams from different pieces of music. Through the combination of these two techniques, a real-time time predict mashup can be generated towards a new form of automatic accompaniment for interactive musical performance.
[Factors influencing the temperature-sensing accuracy of ablation catheters]. (2008)

Factors influencing the temperature-sensing accuracy of an ablation catheter are analyzed, in this paper, from the two aspects of the thermocouple temperature sensor, which are the TC length and the TC hole's diameter of the ablation electrode. Meanwhile, differences between products from different companies are given too.
Intra-vehicle ranging in ultra-wide and millimeter wave bands (2015)

The paper deals with intra-vehicle ranging based on the time of arrival technique. The aim of the presented work is to compare the ranging accuracy in the 3 to 11 GHz ultra-wide band and the 56 to 64 GHz millimeter wave band. The comparison is performed using channel impulse responses calculated from complex transfer functions using a windowed IFFT. The complex transfer functions are measured by a four port vector network analyzer for empty and occupied car scenarios. The obtained results are discussed and differences in ranging accuracy between both bands are explained by means of several reference measurements carried out in an anechoic chamber.
Capacitances of a planar multiconductor configuration on a dielectric substrate by a mixed order finite-element method (1976)

A mixed order finite-element technique is utilized, to solve - Rectangular the Integral equations governing the charge density distribution in a planar Fin~ite-_Eulment multiconductor configuration on a dielectric sheet. The capacitive lumped equivalent model for such a circuit is determined. The four-dimensional integrals with singular integrands, resulting from the formulation, are evaluated symbolically. The method is implemented in a package called PARCAP, and is shown to be competitive with the other programs available at this time. Thin film Interdigitated capacitors were measured to lend support to the accuracy and usefulness of PARCAP in circuit design.
Gaussian beam migration of common‐shot records (2004)

Gaussian beam migration (GBM) (Hill, 1990, 2001) is an elegant, accurate, and efficient depth migration method. It has the ability to image complicated geologic structures with fidelity exceeding that of single‐arrival Kirchhoff migration and approaching that of wave‐equation migration. In fact, its accuracy can exceed that of most wave‐equation migrations in imaging very steep dips, especially in three dimensions and especially in the presence of anisotropy. Poststack GBM is efficient, but a naïve implementation of prestack GBM can be relatively inefficient. Hill's (2001) implementation of prestack GBM takes advantage of symmetries available in common‐offset, common‐azimuth acquisition geometries to provide an extremely accurate method that is far more efficient than the naïve implementation. Unfortunately, different acquisition geometries, such as orthogonal land and marine bottom‐cable geometries do not easily accommodate the requirements of common‐azimuth migration. For these geometries, it might be more natural to perform migration on individual common‐shot or common‐receiver records. In this abstract, I adapt Hill's (2001) method to common‐shot migration. The common‐shot migration described here loses some accuracy compared with Hill's method, in the sense that it doesn't handle multiple arrivals as well. It is possible to overcome this problem (Gray, 2004), but the method described here will be sufficient for the purposes of this abstract, which is to point out some advantages of migrating common‐shot records. In practice, this slight loss of accuracy needs to be weighed against (1) the difficulties (in some geometries) of obtaining regularly sampled regularly sampled common‐offset, common‐azimuth records for migration, and (2) the difficulties in regularizing common‐offset, common‐azimuth data for the premigration slant stack when surface elevations and velocities vary rapidly.
Attenuated Replication-Competent Adenoviruses (ARCA<sup>&copy;</sup>) for Prostate Cancer: CV706 to CV787 (2001)

Research Articles| October 01 2008 Vascular Changes in Gastric Ulcers Subject Area: Further Areas , Oncology , Pathology and Cell Biology I.W. Jennings I.W. Jennings Department of Pathology, University of Cambridge, Cambridge Search for other works by this author on: This Site PubMed Google Scholar Pathologia et Microbiologia (1967) 30 (5): 747–751. https://doi.org/10.1159/000161721 Article history Published Online: October 01 2008 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation I.W. Jennings; Vascular Changes in Gastric Ulcers. Pathologia et Microbiologia 1 May 1967; 30 (5): 747–751. https://doi.org/10.1159/000161721 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPathobiology Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1967Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Natural product discovery from the human microbiome (2017)

Human-associated microorganisms have the potential to biosynthesize numerous secondary metabolites that may mediate important host-microbe and microbe-microbe interactions. However, there is currently a limited understanding of microbiome-derived natural products. A variety of complementary discovery approaches have begun to illuminate this microbial "dark matter," which will in turn allow detailed mechanistic studies of the effects of these molecules on microbiome and host. Herein, we review recent efforts to uncover microbiome-derived natural products, describe the key approaches that were used to identify and characterize these metabolites, discuss potential functional roles of these molecules, and highlight challenges related to this emerging research area.
<title>New approach to simultaneous localization and dynamic map building</title> (1996)

A new method for simultaneous vehicle localization and dynamic map building is described. The method models the noise sources as bounded distributions and can therefore produce bounded estimates for the vehicle and all the target positions. Correlations that arise between vehicle and target estimates when using other techniques, such as the Kalman filter, do not arise, and hence a significant saving in memory and computation is achieved.
PVNet: Pixel-Wise Voting Network for 6DoF Pose Estimation (2019)

This paper addresses the challenge of 6DoF pose estimation from a single RGB image under severe occlusion or truncation. Many recent works have shown that a two-stage approach, which first detects keypoints and then solves a Perspective-n-Point (PnP) problem for pose estimation, achieves remarkable performance. However, most of these methods only localize a set of sparse keypoints by regressing their image coordinates or heatmaps, which are sensitive to occlusion and truncation. Instead, we introduce a Pixel-wise Voting Network (PVNet) to regress pixel-wise vectors pointing to the keypoints and use these vectors to vote for keypoint locations. This creates a flexible representation for localizing occluded or truncated keypoints. Another important feature of this representation is that it provides uncertainties of keypoint locations that can be further leveraged by the PnP solver. Experiments show that the proposed approach outperforms the state of the art on the LINEMOD, Occlusion LINEMOD and YCB-Video datasets by a large margin, while being efficient for real-time pose estimation. We further create a Truncation LINEMOD dataset to validate the robustness of our approach against truncation. The code is available at https://zju3dv.github.io/pvnet/.