gebhart/patrepeval huggingface dataset:
An association study using AFLP markers and application to a beef cattle breeding population (2004)

Using amplified fragment length polymorphism (AFLP) fingerprinting, selective genotyping was performed to determine if this method was effective for selecting superior breeding stock. Forty-eight cows with extreme genetic merit for beef marbling score (BMS) were selected from a population of Japanese Black cattle (n = 4462), including 25 with the highest for predicted breeding value (PBV) and 23 with the lowest. Sixteen AFLP fragments were selected for further analysis based on fragment frequency differences between the high and low groups. A linear discriminant analysis using these AFLP fragments was applied in order to derive a discriminant function that classified the cows into high and low groups. Seven of the 16 fragments were included in the resulting function and the discriminant scores (general genetic values, GGV) of the 48 cows were calculated using the function. These cows were clearly separated into high and low groups by GGV with a correlation ratio of 0.91 (discriminative error of 2.1%). The same function was then applied to 121 additional cows that were randomly selected from the original population. A significant regression coefficient of GGV on BMS-PBV (R2 = 0.45) was obtained, which indicates that the GGV can be used as a selection criterion for BMS in this population. These results suggest that AFLP fingerprinting can be used for animal breeding without identifying the underlying genes affecting the trait of interest.
Transient Ubiquitin Cross-Reactive Protein Gene Expression in the Bovine Endometrium (1997)

Bovine ubiquitin cross-reactive protein (boUCRP) is secreted by the endometrium from days 15 to 26 of pregnancy in response to conceptus-derived interferon-tau (IFN-tau). We hypothesized that the gene encoding boUCRP was under transcriptional control by the conceptus and IFN-tau. Northern blots using radiolabeled UCRP cDNA revealed a single UCRP transcript of approximately 700 b that was present (P < 0.05) in endometrial cells cultured with 25 nM rboIFN-tau. The UCRP mRNA was not detected in endometrium on days 15, 17, 18 or 19 of the estrous cycle (n = 4 cows on each day) or in spleen, kidney, liver, corpus luteum or muscle. Bovine UCRP mRNA was detectable (P < 0.05) in endometrium from pregnant cows by day 15, reached highest levels by day 17, remained elevated on days 18, 19 and 21, and then declined to amounts on day 26 that were not detectable. Northern blot using radiolabeled ubiquitin cDNA revealed presence of the two major ubiquitin transcripts UbB (1.2 Kb) and UbC (2.6 Kb) in all tissues examined. The bovine UCRP cDNA did not cross-hybridize with these ubiquitin transcripts. We conclude that transcription of the UCRP gene is transient during early pregnancy and regulated by IFN-tau.
Mobile multi-modal data services for GPRS phones and beyond (2003)

The paper discusses means to build multi-modal data services in existing GPRS infrastructures, and puts the proposed simple solutions into the perspective of technological possibilities that will become available in public mobile communications networks over the next few years along the progression path from 2G/GSM systems, through GPRS, to 3G systems like UMTS, or equivalently to 802.11 networks. Three demonstrators are presented, which were developed by the authors in an application-oriented research project co-financed by telecommunications companies. The first two, push-to-talk address entry for a route-finder, and an open-microphone map-content navigator simulate a UMTS or WLAN scenario. The third demonstrator implements a multi-modal map finder in a live public GPRS network using WAP-Push. Indications of usability are given. The paper argues for the importance of open, standards-based architectures that will spur attractive multi-modal services in the short term, as current economic difficulties in the telecommunications industry put support for long term research into more advanced forms of multi-modality in question.
Thermal Stability of Self-Assembled Monolayers (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal Stability of Self-Assembled MonolayersE. Delamarche, B. Michel, H. Kang, and Ch. GerberCite this: Langmuir 1994, 10, 11, 4103–4108Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/la00023a033https://doi.org/10.1021/la00023a033research-articleACS PublicationsRequest reuse permissionsArticle Views2399Altmetric-Citations234LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Generation Of A Line Description File For Graphics Recognition (1988)

A typical office document or an engineering drawing consists of regions of text, graphics, and halftone images. Developing algorithms for automating the input of such documents is the goal of this research. The scope of this paper is the design of algorithms to process raster-oriented binary images of paper-based graphics to obtain vector-oriented description files. The image is preprocessed to suppress noise and other digitization artifacts. The graphical components are then represented as a union of maximal squares using the maximal square moving algorithm. The pointers describing the connectivity of the maximal squares are analyzed to generate a linked list of squares. Straight line segments, curves, junctions, and large areas are then identified after extensive processing of this linked list. The output of the algorithm is a graphics description file which is then used as input to a graphics recognition system.
Synthesis of Recyclable Tire Additives via Equilibrium Ring-Opening Metathesis Polymerization (2016)

Linear trans-polypentenamers are highly desired materials among synthetic tire additives due to their comparable physical properties to natural rubber. trans-Polypentenamer can be prepared by equilibrium ring-opening metathesis polymerization (ROMP) using well-defined ruthenium catalyst systems. This unique feature of the equilibrium polymerization reaction opens a way for the synthesis of durable, environmentally benign elastomers where polymers including synthetic tire additives can be synthesized and readily recycled using the same transition metal catalyst system. The addition of silica fillers significantly improves the physical properties of the composite materials in comparison to the use of polymeric material. It is also known that the structural effects and the polymer–filler surface interaction are of prime importance. Herein, we report on the synthesis of silica filler compatible recyclable polypentenamer copolymers via equilibrium ROMP of cyclopentene 1 and 4-(triethoxy)siloxy cyclopentene 11. It has been demonstrated that polypentenamer tire additives can be synthesized via equilibrium ROMP affording polymers with high yields (>80%) at 0 °C and can be readily depolymerized at 40 °C and/or under diluted conditions using the same metathesis catalyst systems. Furthermore, the polypentenamer can also be synthesized in neat at room temperature and at very low (105) monomer/catalyst ratio. This methodology is based on the synthesis of polyolefins utilizing a ruthenium-based metathesis catalyst via equilibrium ROMP of cyclopentenes and their silylated derivatives.
Novel pathophysiological role of classical chemotactic peptide receptors and their communications with chemokine receptors (2000)

The bacterial N-formylpeptides, such as N-formyl-Met-Leu-Phe (fMLF), are some of the first identified and most potent chemoattractants for phagocytic leukocytes. Two fMLF receptors, the high affinity formyl peptide receptor (FPR) and its low affinity variant FPR-like 1 (FPRL1), belong to the seven-transmembrane, Gi protein-coupled receptor superfamily which also includes chemokine receptors. Despite their reaction with bacterial chemotactic peptides, the physiological role of these receptors in humans remains unclear. Our recent studies have identified novel exogenous as well as host-derived agonists for FPR and FPRL1. Furthermore, activation of these receptors by their agonists results in desensitization of the receptors for other chemoattractants, including two chemokine receptors, CCR5 and CXCR4, which serve as major co-receptors for HIV-1. These results suggest that FPR and FPRL1 may play important roles not only in host defense and immunological responses but also in the fine tuning of cell activation in the presence of multiple stimuli.
Strategies Using Bio-Layer Interferometry Biosensor Technology for Vaccine Research and Development (2017)

Bio-layer interferometry (BLI) real-time, label-free technology has greatly contributed to advances in vaccine research and development. BLI Octet platforms offer high-throughput, ease of use, reliability, and high precision analysis when compared with common labeling techniques. Many different strategies have been used to immobilize the pathogen or host molecules on BLI biosensors for real-time kinetics and affinity analysis, quantification, or high-throughput titer. These strategies can be used in multiple applications and shed light onto the structural and functional aspects molecules play during pathogen-host interactions. They also provide crucial information on how to achieve protection. This review summarizes some key BLI strategies used in human vaccine research and development.
Effects of ergoline derivatives on intraocular pressure and iris function in rabbits and monkeys (1982)

The ergoline derivatives, bromocriptine, lergotrile and pergolide, are potent dopaminergic agonists. Topically administered doses of lergotrile and pergolide, ranging from 0.001 to 1% applied unilaterally, produced dose and time-related ocular hypotension in rabbits and monkeys. In contrast, bromocriptine produced moderate ocular hypotension in rabbits but not in monkeys. Lergotrile (1%) produced significant mydriasis in rabbits whereas pergolide (0.01 to 0.1%) produced a slight miosis. Lergotrile and pergolide were also effective in suppressing ocular hypertension induced by water loading in rabbits whereas bromocriptine was relatively ineffective. These data demonstrate that topically administered ergoline derivatives can: 1) lower intraocular pressure in rabbits and monkeys, 2) suppress ocular hypertension induced by water loading in rabbits and 3) alter iris function in rabbits, producing either mydriasis or miosis, presumably by activation of adrenoceptors.
Flexible Alkyne-Linked Thymidine Phosphoramidites and Triphosphates for Chemical or Polymerase Synthesis and Fast Postsynthetic DNA Functionalization through Copper-Catalyzed Alkyne–Azide 1,3-Dipolar Cycloaddition (2018)

Two alternative flexible alkyne-linked thymine nucleosides (propargyl-diethylene glycol- or undecyn-linked 5-hydroxymethyluracil derivatives), as well as their phosphoramidites and triphosphates, were designed and synthesized. The nucleoside 3'- O-phosphoramidites were successfully incorporated into oligonucleotides on a solid support, whereas the nucleoside triphosphates served as good substrates for polymerase synthesis of modified DNA, which underwent fast and efficient copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC) reactions.
Event aggregation and distribution in Web-based management systems (2003)

As networks grow in size, managers rely increasingly on asynchronous notifications (events) for most management tasks. With the increasing popularity of the Web as a means of providing access to network management services, there is a strong demand for enabling platforms that provide these services in a scalable and cost-effective way. This paper presents the architecture of the event generation and distribution subsystem of the Marvel (Anerousis, 1998) distributed management environment. The latter allows the network manager to define new event types by aggregating lower level events and make them available to a variety of client applications through the brokerage services of a distributed computing environment. Events are serialized objects that can carry Java byte code to display themselves according to the event consumer's graphical capabilities, or possibly take a corrective action if the event corresponds to a fault condition. Event filtering and aggregation is performed by an external process, operating under the control of the Marvel event management service. The architecture has been applied on an existing management platform based on Marvel for a home broadband access service.
An open CNC system based on switched ethernet (2010)

The switched Ethernet, which has many features for real-time communications such as micro-segmentation of network traffic and full-duplex links, has become one of the hot research issues toward real-time Ethernet. This paper proposes an open CNC system based on the switched Ethernet including the star topology architecture and the real-time communication mechanism according to the character of traffic flows in the CNC systems. To achieve the real-time performance, a service cycle of the switch is divided into two parts for hard real-time applications and other applications respectively and a feasibility check algorithm is introduced as the admission control. Finally the implementation of a prototype system is described and the results based on the prototype system show this method is feasible and effective.
Oral Administration of Bifidobacterium longum Ameliorates Influenza Virus Infection in Mice (2011)

We investigated whether the oral administration of Bifidobacterium longum BB536 could ameliorate influenza virus (IFV) infection in a mice model. Mice were orally administrated BB536 or saline for 2 weeks and then infected with IFV. Orally administered BB536 significantly alleviated symptoms, reduced the loss of body weight, and inhibited viral proliferation in the lungs relative to the control group findings. Histopathological findings in the lungs were improved in the BB536 group compared to control group findings. There was no significant difference in the levels of interleukin-6 (IL-6), interferon-γ (IFN-γ), IL-10 and IL-12p40 in the lungs between the groups, but the levels of IL-6 and IFN-γ were lower (p=0.076, 0.103, respectively) in the BB536 group compared with those of control group. The levels of IL-6 and IL-10 correlated significantly with the values of weight loss, and the levels of IFN-γ correlated with the virus titers in the lungs. These results suggested the potential of the oral administration of BB536 in ameliorating IFV infection and the possible involvement of anti-inflammatory effects of BB536 in the anti-infection effects against IFV.
Effective Sensor Selection and Data Anomaly Detection for Condition Monitoring of Aircraft Engines (2016)

In a complex system, condition monitoring (CM) can collect the system working status. The condition is mainly sensed by the pre-deployed sensors in/on the system. Most existing works study how to utilize the condition information to predict the upcoming anomalies, faults, or failures. There is also some research which focuses on the faults or anomalies of the sensing element (i.e., sensor) to enhance the system reliability. However, existing approaches ignore the correlation between sensor selecting strategy and data anomaly detection, which can also improve the system reliability. To address this issue, we study a new scheme which includes sensor selection strategy and data anomaly detection by utilizing information theory and Gaussian Process Regression (GPR). The sensors that are more appropriate for the system CM are first selected. Then, mutual information is utilized to weight the correlation among different sensors. The anomaly detection is carried out by using the correlation of sensor data. The sensor data sets that are utilized to carry out the evaluation are provided by National Aeronautics and Space Administration (NASA) Ames Research Center and have been used as Prognostics and Health Management (PHM) challenge data in 2008. By comparing the two different sensor selection strategies, the effectiveness of selection method on data anomaly detection is proved.
PEM fuel cell catalyst degradation mechanism and mathematical modeling (2008)

Durability of carbon-supported platinum nanoparticle is one of the limiting factors for PEM fuel cell commercial applications. In our research work, we applied both experimental and mathematical simulative tools to study the mechanisms of Pt/C catalyst degradation. An accelerated catalyst degradation protocol by cycling the cathode potential in a square-wave profile was applied to study the losses of cell performances, catalyst ORR activity, and Pt active surface areas. Post-mortem analyses of cathode Pt particle size by X-ray diffraction and platinum distributions in CCMs by SEM/EDS were also conducted. Increased cell temperature and relative humidity was found to accelerate the cathode catalyst degradation. High membrane water contents or abundant water/ionic channels within the polymer electrolyte were believed to accelerate Pt ion transport and cathode degradation. After degradation tests, significant amount of Pt loss into the membrane forming a Pt "band" was observed through cathode platinum dissolution and chemical reduction of soluble Pt ions by permeated hydrogen from the anode. Platinum deposition was confirmed at a location where the permeated hydrogen and oxygen had the complete catalytic combustion over the deposited Pt clusters/particles as the catalyst. A cathode degradation model was built including the processes of platinum oxidation, dissolution/replating, diffusion of Pt ions and Pt band formation in electrolyte. A simplified bi-modal particle size distribution was applied with equal numbers of small and large type particles uniformly distributed in the cathode initially. Processes of Pt mass exchange between two types of particles were demonstrated to cause the overall particle growth. This was due to the particle size effect that platinum dissolution from the small type particles and replating of Pt ions onto the large particles was favored. Parametric study found the increased upper cycling potential was the dominated factor to accelerate the catalyst degradation. Also high frequency of potential cycle and low surface oxide coverage accelerated the degradation rate. Pt dissolution and oxidation processes in perchloric acid were preliminary investigated, and both chemical and electrochemical processes of oxidation and dissolution were believed to be involved under closed-circuit fuel cell conditions with oxygen presence at cathode.
Metalorganic Chemical Vapor Deposition of ZnO Using D<sub>2</sub>O as Oxidant (1994)

ZnO films with low resistivity and high transparency in a wavelength range of 400 nm–1300 nm were successfully grown by the metalorganic chemical vapor deposition (MOCVD) technique using D 2 O as a new oxidant for diethylzinc on glass substrates. It was also found that the crystal orientation of the films was strongly dependent on the substrate temperature. By employing both D 2 O and H 2 O as oxidants for diethylzinc, the surface morphology of low-resistivity ZnO films could be modified. The obtained films are suitable as transparent conducting materials.
ISI-reduced modulation over a fading multipath channel (2003)

The idea of using the channel eigenvectors as the basis for a block based signaling scheme over a fading multipath channel is introduced. This basis minimizes the product of the average fading attenuations along different dimensions. The ISI from the preceding blocks (intra-block ISI) is modeled by an additive Gaussian noise. To reduce the effect of the intra-block ISI, a number of zeros are transmitted between successive blocks. The number of zeros is optimized to minimize the average probability of error. As the transmission of zeros reduces the bandwidth efficiency, this optimization procedure is more useful for lower bit rates. By applying quadrature amplitude modulation (QAM) to each dimension, a set of two-dimensional subchannels with unequal fadings is obtained. A coherent M-PSK constellation is employed over each QAM subchannel. The authors propose two methods to distribute the rate and energy between the subchannels.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Testing of detection systems (2002)

The phrase "probability of detection" (P/sub d/) is often misused in the context of exterior electronic perimeter intrusion detection systems (PIDS). For example, a system which correctly detects when tested three times has detected at a rate of 100%, but might not have a "probability of detection" of 100%. "P/sub d/" is often misused to describe this experimental result as a 100% probability of detection. "Confidence limits" for P/sub d/ can be estimated and minimum extents for testing can then be demanded. These confidence limits are sometimes calculated using the normal, or the chi-squared, statistical distributions. Using these distributions for PIDS testing is questionable because they are often used outside their region of validity. There are fundamental constraints which obstruct conventional statistical confidence limits for P/sub d/ from being found. P/sub d/ statistics are discussed and an exact way to express detection uncertainty using the binomial distribution is described. Ways to reduce testing, yet maintain confidence, are discussed. Experts are concerned that extensive, but unrepresentative, testing gives an unwarranted impression of reliability. This paper emphasises the importance of representative testing and the clear presentation of results.
<i>Staphylococcus aureus</i>and its food poisoning toxins: characterization and outbreak investigation (2011)

Staphylococcal food poisoning (SFP) is one of the most common food-borne diseases and results from the ingestion of staphylococcal enterotoxins (SEs) preformed in food by enterotoxigenic strains of Staphylococcus aureus. To date, more than 20 SEs have been described: SEA to SElV. All of them have superantigenic activity whereas half of them have been proved to be emetic, representing a potential hazard for consumers. This review, divided into four parts, will focus on the following: (1) the worldwide story of SFP outbreaks, (2) the characteristics and behaviour of S. aureus in food environment, (3) the toxinogenic conditions and characteristics of SEs, and (4) SFP outbreaks including symptomatology, occurrence in the European Union and currently available methods used to characterize staphylococcal outbreaks.