gebhart/patrepeval huggingface dataset:
Energy-Efficient Management of Data Center Resources for Cloud\n Computing: A Vision, Architectural Elements, and Open Challenges (2010)

Cloud computing is offering utility-oriented IT services to users worldwide.\nBased on a pay-as-you-go model, it enables hosting of pervasive applications\nfrom consumer, scientific, and business domains. However, data centers hosting\nCloud applications consume huge amounts of energy, contributing to high\noperational costs and carbon footprints to the environment. Therefore, we need\nGreen Cloud computing solutions that can not only save energy for the\nenvironment but also reduce operational costs. This paper presents vision,\nchallenges, and architectural elements for energy-efficient management of Cloud\ncomputing environments. We focus on the development of dynamic resource\nprovisioning and allocation algorithms that consider the synergy between\nvarious data center infrastructures (i.e., the hardware, power units, cooling\nand software), and holistically work to boost data center energy efficiency and\nperformance. In particular, this paper proposes (a) architectural principles\nfor energy-efficient management of Clouds; (b) energy-efficient resource\nallocation policies and scheduling algorithms considering quality-of-service\nexpectations, and devices power usage characteristics; and (c) a novel software\ntechnology for energy-efficient management of Clouds. We have validated our\napproach by conducting a set of rigorous performance evaluation study using the\nCloudSim toolkit. The results demonstrate that Cloud computing model has\nimmense potential as it offers significant performance gains as regards to\nresponse time and cost saving under dynamic workload scenarios.\n
social giftedness - its characteristics and identification (1995)

The writer argues that just as high ability exists in the creative, cognitive and psychomotor domains there is high ability in the psychosocial domain and one of its facets is social giftedness. A definition of social giftedness is provided. The research design is described. Then the researcher sets out to identify the specific behaviours associated with social giftedness and constructs a measure. Individuals are identified from this measure who are subjected to interview, a personality test, and detailed case study. General findings are discussed.
Tetracyano-p-phenylenediamine (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTetracyano-p-phenylenediamineO. W. Webster, M. Brown, and R. E. BensonCite this: J. Org. Chem. 1965, 30, 9, 3250–3252Publication Date (Print):September 1, 1965Publication History Published online1 May 2002Published inissue 1 September 1965https://pubs.acs.org/doi/10.1021/jo01020a535https://doi.org/10.1021/jo01020a535research-articleACS PublicationsRequest reuse permissionsArticle Views325Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Control of oligomeric enzyme thermostability by protein engineering. (1987)

The ability to control the resistance of an enzyme to inactivation due to exposure to elevated temperatures is essential for the understanding of thermophilic behavior and for developing rational approaches to enzyme stabilization. By means of site-directed mutagenesis, point mutations have been engineered in the dimeric enzyme yeast triosephosphate isomerase that improve its thermostability. Cumulative replacement of asparagine residues at the subunit interface by residues resistant to heat-induced deterioration and approximating the geometry of asparagine (Asn-14----Thr-14 and Asn-78----Ile-78) nearly doubled the half-life of the enzyme at 100 degrees C, pH 6. Moreover, in an attempt to model the deleterious effects of deamidation, we show that replacement of interfacial Asn-78 by an aspartic acid residue increases the rate constant of irreversible thermal inactivation, drastically decreases the reversible transition temperature, and reduces the stability against dilution-induced dissociation.
The Child Victim as a Witness in Sexual Abuse Cases (1985)

3. Of the 528 cases of substantiated sexual abuse reported to the Department of Social and Rehabilitation Services, 26% of the victims were age five and younger.Fifty-six percent were under the age of ten.Id.4. Until recently, many states required corroboration of a victim's testimony, and consequently many cases were not able to be prosecuted at all.Now, however, corroboration is no longer required in most states.B. MoRAsco, THE PROSECUTION AND DEFENSE OF SEX
Identification of model parameters and associated uncertainties for robust control design (1994)

The integration of system identification and robust control is considered. The identification algorithm is an extended Kalman filter, and the robust control algorithm is based on Petersen-Holl ot's bounds (modified for random correlated parameters). The identification and control problems are coupled because the inputs for the identification experiment are selected to optimize the robust control performance. The optimization problem, interpreted as a form of Riccati equation control, is solved by exploiting the analytical properties of the Riccati equation in a nontraditional manner. The result appears an equivalent quadratic-linear boundary-value-problem, which allows a convergent numerical solution. An effective numerical algorithm is also offered for solving the extended Kalman filter equations in high-dimensional modal test problems. The algorithm is based on block decomposition of the modal state-space model. The developed approach is applied to the Middeck Active Control Experiment (MACE) testbed. MACE is an MIT STS flight experiment scheduled for launch in 1994.
Identification of new localized RNAs in the Xenopus oocyte by differential display PCR (1996)

We have identified localized transcripts in full-grown Xenopus oocytes by differential display PCR. One clone, An4a, has two transcripts, which localize to the animal half of the stage VI oocyte. The transcripts are expressed throughout early development, with embryonic expression primarily in anterior neural tissues. An4a has a high degree of sequence identity to a human cDNA clone of unknown function. Another clone, the previously identified β-transducin repeat containing protein (β-TrCP), has three transcripts with a unique pattern of localization, one localized to the animal half and two localized primarily to the vegetal cortex. This cDNA has previously been shown to rescue a yeast cell division cycle mutant, raising the possibility that the different Xenopus transcripts are involved in animal and vegetal cell cycles. Embryonic expression is primarily in the cement gland. These new localized transcripts contribute to the general observation that the vegetal cortex, but not the animal cortex, is a specific site for RNA localization. © 1996 Wiley-Liss, Inc.
Prospective Study of Serum Micronutrients and Ovarian Cancer (1996)

Given the small size of this study and the inconsistency of results among the few prospective studies of ovarian cancer conducted to test these associations, replications of these findings are highly desirable.
Growth retardation and skin abnormalities of the Recql4-deficient mouse (2003)

Mutations in the Recql4 gene are very likely responsible for a subset of Rothmund-Thomson syndrome (RTS) cases, but until now there has been no animal model to confirm this. Knockout mice in which the Recql4 gene is disrupted at exons 5-8 exhibit embryonic lethality at embryonic day 3.5-6.5. We generated a helicase activity-inhibited mouse by deleting exon 13 of Recql4, which is one of the coding exons of the consensus RecQ-helicase domain. This domain is the primary site of mutations that have been identified in RTS patients. The exon 13-deleted Recql4-deficient mice are viable, but exhibit severe growth retardation and abnormalities in several tissues, and embryonic fibroblasts show a defect in cell proliferation. Abnormalities in the Recql4-deficient mice are similar to those in RTS patients, suggesting that defects in the Recql4 gene may indeed be responsible for RTS. We speculate that the loss of Recql4 helicase activity results in the prematurely aged appearance observed in some RecQ helicase diseases.
Potential of Activated Prothrombin Complex Concentrate and Activated Factor VII to Reverse the Anticoagulant Effects of Rivaroxaban in Primates (2008)

Abstract Rivaroxaban is an oral, direct Factor Xa (FXa) inhibitor that has been recommended for approval by the Committee for Medicinal Products for Human Use for the prevention of venous thromboembolism after elective hip and knee replacement, and is in advanced clinical development for the prevention and treatment of thromboembolic disorders. Because bleeding is a potential side-effect of accidental rivaroxaban overdose, we evaluated whether activated prothrombin complex concentrate (APCC, FEIBA®) and recombinant activated Factor VII (rFVIIa, NovoSeven®) administration could mitigate the antihemostatic effects of high-dose rivaroxaban in juvenile male baboons. Pharmacologic impairment of hemostasis (3- to 4-fold increase in prothrombin time [PT] from baseline and ≥2-fold increase in template bleeding time [BT]) was achieved by an intravenous (i.v.) bolus of rivaroxaban (0.6 mg/kg) followed by continuous infusion (0.6 mg/kg/h) for 60 minutes. At steady-state anticoagulation (30 minutes from bolus), one group of anticoagulated baboons (n=7) received APCC (50 U/kg, over 25 minutes). A second group (n=7) received an i.v. bolus dose of rFVIIa (210 μg/kg) 30 minutes after the start of anticoagulation. Reversal of the antihemostatic effects of supratherapeutic doses of rivaroxaban by APCC and rFVIIa was assessed by measurement of BT and clotting times. In the APCC group, high-dose rivaroxaban prolonged BT to 202% (95% CI±21%; p<0.001) of baseline and PT by 3-fold (Table). On completion of APCC infusion, BT returned to baseline and PT was reduced. In the rFVIIa group, rivaroxaban prolonged BT to 254% (95% CI±30%; p<0.05). Infusion of rFVIIa reduced BT by 34%, and PT was also shortened. Circulating thrombin–antithrombin complex (TAT) levels decreased during rivaroxaban infusion, and this decrease did not change significantly after rFVIIa bolus administration. However, APCC increased baseline plasma TAT levels, suggesting a systemic hypercoagulation. We conclude that administration of APCC or rVIIa can rapidly attenuate hemostasis impairment after rivaroxaban overdose in baboons, thus providing potential antidotes during bleeding emergencies. Table. The effect of activated prothrombin complex concentrate (APCC) and recombinant activated Factor VII (rFVIIa) on bleeding time (BT), prothrombin time (PT), and thrombin–antithrombin complex concentration (TAT) in baboons anticoagulated with high-dose rivaroxaban (n=7 each). Values are given as mean ± standard deviation Time BT (x-fold change from baseline) PT (x-fold change from baseline) TAT (μg/L) APCC Baseline 1.00 1.00 3.51±0.08 30 minutes after rivaroxaban 2.02±0.56 3.04±0.43 3.01±1.37 At end of APCC infusion 1.02±0.33 2.20±0.29 10.35±1.41 20 minutes after end of APCC infusion 1.65±0.94 2.28±0.29 n.d. rFVIIa Baseline 1.00 1.00 7.35±4.17 30 minutes after rivaroxaban 2.54±0.79 3.17±0.42 2.95±0.79 5 minutes after rFVIIa 1.68±0.80 2.38±0.41 2.58±0.52 30 minutes after rFVIIa 1.96±1.26 2.48±0.49 4.00±1.12
Identification and Isolation of Single Cells that Produce Somatic Embryos at a High Frequency in a Carrot Suspension Culture (1985)

A system was established in which single cells differentiated to embryos at a high frequency. Small spherical single cells from a carrot (Daucus carota L. cv "Kurodagosun") cell suspension culture were obtained by fractionation through sieving, using nylon screens and then density gradient centrifugation in Percoll solutions. Eighty-five to 90% of these small single cells differentiated to embryos when they were cultured in a medium containing 2,4-dichlorophenoxyacetic acid (5 x 10(-8) molar), zeatin (10(-6) molar), and mannitol (0.2 molar) for 7 days, followed by transfer to a medium containing zeatin (10(-7) molar) but no auxin. This indicates that there are at least two phases in the differentiation of embryos from single cells. The progression of the first phase required exogenous auxin, whereas that of the second phase was inhibited by the same growth regulator. The relationship between the morphology and potency for embryogenesis from single cells was discussed. The system established here is a useful one for investigation of differentiation process from a single cell to a whole plant via embryogenesis, especially in its early stage.
Effect of an Interfacial Layer on Electron Tunneling through Atomically Thin Al<sub>2</sub>O<sub>3</sub> Tunnel Barriers (2017)

Electron tunneling through high-quality, atomically thin dielectric films can provide a critical enabling technology for future microelectronics, bringing enhanced quantum coherent transport, fast speed, small size, and high energy efficiency. A fundamental challenge is in controlling the interface between the dielectric and device electrodes. An interfacial layer (IL) will contain defects and introduce defects in the dielectric film grown atop, preventing electron tunneling through the formation of shorts. In this work, we present the first systematic investigation of the IL in Al<sub>2</sub>O<sub>3</sub> dielectric films of 1-6 Å's in thickness on an Al electrode. We integrated several advanced approaches: molecular dynamics to simulate IL formation, in situ high vacuum sputtering atomic layer deposition (ALD) to synthesize Al<sub>2</sub>O<sub>3</sub> on Al films, and in situ ultrahigh vacuum scanning tunneling spectroscopy to probe the electron tunneling through the Al<sub>2</sub>O<sub>3</sub>. The IL had a profound effect on electron tunneling. We observed a reduced tunnel barrier height and soft-type dielectric breakdown which indicate that defects are present in both the IL and in the Al<sub>2</sub>O<sub>3</sub>. The IL forms primarily due to exposure of the Al to trace O<sub>2</sub> and/or H<sub>2</sub>O during the pre-ALD heating step of fabrication. As the IL was systematically reduced, by controlling the pre-ALD sample heating, we observed an increase of the ALD Al<sub>2</sub>O<sub>3</sub> barrier height from 0.9 to 1.5 eV along with a transition from soft to hard dielectric breakdown. This work represents a key step toward the realization of high-quality, atomically thin dielectrics with electron tunneling for the next generation of microelectronics.
Lipocalin-Type Prostaglandin D Synthase and Egg White Cystatin React with IgE Antibodies from Children with Egg Allergy (2010)

We demonstrated that L-PGDS and cystatin reacted with serum IgE in patients with egg allergy. Our proteomics-based analysis in egg white gives a comprehensive map of proteins bound with IgE and should assist in enabling more accurate diagnoses and recommendations of desensitizing treatments for individual patients.
Site-selective immobilisation of functional enzymes on to polystyrene nanoparticles (2009)

The immobilisation of proteins on to nanoparticles has a number of applications ranging from biocatalysis through to cellular delivery of biopharmaceuticals. Here we describe a phosphopantetheinyl transferase (Sfp)-catalysed method for immobilising proteins bearing a small 12-mer "ybbR" tag on to nanoparticles functionalised with coenzyme A. The Sfp-catalysed immobilisation of proteins on to nanoparticles is a highly efficient, single step reaction that proceeds under mild conditions and results in a homogeneous population of proteins that are covalently and site-specifically attached to the surface of the nanoparticles. Several enzymes of interest for biocatalysis, including an arylmalonate decarboxylase (AMDase) and a glutamate racemase (GluR), were immobilised on to nanoparticles using this approach. These enzymes retained their activity and showed high operational stability upon immobilisation.
Functional and Morphological Differences among Intrinsically Photosensitive Retinal Ganglion Cells (2009)

A subset of ganglion cells in the mammalian retina express the photopigment melanopsin and are intrinsically photosensitive (ipRGCs). These cells are implicated in non-image-forming visual responses to environmental light, such as the pupillary light reflex, seasonal adaptations in physiology, photic inhibition of nocturnal melatonin release, and modulation of sleep, alertness, and activity. Morphological studies have confirmed the existence of at least three distinct subpopulations of ipRGCs, but studies of the physiology of ipRGCs at the single cell level have focused mainly on M1 cells, the dendrites of which stratify solely in sublamina a (OFF sublamina) of the retinal inner plexiform layer (IPL). Little work has been done to compare the functional properties of M1 cells to those of M2 cells, the dendrites of which stratify solely in sublamina b (ON sublamina) of the IPL. The goal of the current study was to compare the morphology, intrinsic light response, and intrinsic membrane properties of M1 and M2 cells in the mouse retina. Here we demonstrate additional morphological differences between M1 and M2 cells as well as distinct physiological characteristics of both the intrinsic light responses and intrinsic membrane properties. M2 cells displayed a more complex dendritic arborization and higher input resistance, yet showed lower light sensitivity and lower maximal light responses than M1 cells. These data indicate morphological and functional heterogeneity among ipRGCs.
VirHab - A virtual reality system for treatment of chronic pain and disability (2009)

In recent years several lines of research have provided scientific evidence for the therapeutic value of non-invasive methods based on visual feedback and motor imagery. Clinical studies have demonstrated their potential to benefit some patient populations such as cerebrovascular accident (CVA) and complex regional pain syndrome (CRPS). This type of intervention appears appropriate for implementation using virtual reality (VR) technology which can provide the required stimuli. The present study proposes a new VR system based on a motion capture platform, and is currently targeted at treating pain and impairment of upper extremities. The system employs image processing algorithms so the patient sees himself on a screen within a virtual environment. His impaired arm, however, is replaced by a virtual arm. Thus upon making small movements of his paretic arm, he can view his image performing healthy full-range movements with the virtual arm. We hypothesize that this would facilitate plastic changes in the brain, leading to reduced pain and improved function of the impaired limb.
Reversal of Behavioral and Metabolic Abnormalities, and Insulin Resistance Syndrome, by Dietary Restriction in Mice Deficient in Brain-Derived Neurotrophic Factor (2003)

Dietary restriction (DR) extends life span and improves glucose metabolism in mammals. Recent studies have shown that DR stimulates the production of brain-derived neurotrophic factor (BDNF) in brain cells, which may mediate neuroprotective and neurogenic actions of DR. Other studies have suggested a role for central BDNF signaling in the regulation of glucose metabolism and body weight. BDNF heterozygous knockout (BDNF+/-) mice are obese and exhibit features of insulin resistance. We now report that an intermittent fasting DR regimen reverses several abnormal phenotypes of BDNF(+/-) mice including obesity, hyperphagia, and increased locomotor activity. DR increases BDNF levels in the brains of BDNF(+/-) mice to the level of wild-type mice fed ad libitum. BDNF(+/-) mice exhibit an insulin-resistance syndrome phenotype characterized by elevated levels of circulating glucose, insulin, and leptin; DR reduces levels of each of these three factors. DR normalizes blood glucose responses in glucose tolerance and insulin tolerance tests in the BDNF(+/-) mice. These findings suggest that BDNF is a major regulator of energy metabolism and that beneficial effects of DR on glucose metabolism are mediated, in part, by BDNF signaling. Dietary and pharmacological manipulations of BDNF signaling may prove useful in the prevention and treatment of obesity and insulin resistance syndrome-related diseases.
Progression of Vertebral and Spinal Three-Dimensional Deformities in Adolescent Idiopathic Scoliosis (2001)

The results of this study challenge the existence of a typical scoliotic evolution pattern and suggest that scoliotic evolution is quite variable and patient specific.
E-biobanking: What Have You Done to My Cell Samples? (2013)

The rise in biobanking (collecting and storing human biological material) has increased the need to store large quantities of related data and make that data available to researchers and others. However, this introduces concerns regarding data security and dependability. The BiobankCloud project is developing technology to help create e-biobanking ecosystems based on a secure, dependable private-public "cloud of clouds" accessed through platform-as-a-service interfaces.
Self-tuning pole-placement multivariable control of blood pressure for post-operative patients: a model-based study (1990)

The paper describes the extension of pole-placement self-tuning algorithms to the multivariable control of human blood pressure in post-operative patients. The work is based on two nonlinear nonpulsatile models for the cardiovascular system due to Moller and Wesseling et al. These models have a well-grounded physiological basis and include several reflex control systems which are inherent in the body. Two forms of control are presented, the first of which considers a fast dynamic response controller which manipulates heart rate and systemic resistance directly. The second control strategy includes the drug dynamics for sodium nitroprusside and dopamine being administered simultaneously. Both control schemes gave good performance using poleplacement self-tuning, although the first approach gave significant interaction between the loops.
Molecular cloning of cDNA that encode MHC class I molecules from a New World primate ( <i>Saguinus oedipus</i> ). Natural selection acts at positions that may affect peptide presentation to T cells. (1990)

To investigate the evolutionary pressures that drive the generation of polymorphism in primate MHC class I molecules, three cDNA that encode MHC class I alleles from a New World monkey, the cotton-top tamarin (Saguinus oedipus), were cloned and sequenced. These tamarin MHC class I alleles contained amino acid substitutions not found in any of the previously sequenced human MHC class I alleles. Moreover, the majority of these unique amino acid substitutions was located in the Ag recognition site at positions that have been shown to be critical in the presentation of viral peptides to T cells in mice and humans. These data suggest that selective pressures on MHC class I molecules preferentially act on the Ag recognition site and that the peptide binding or presenting functions of these molecules may drive the generation of MHC class I polymorphism. The novel Ag recognition sites of the tamarin MHC class I molecules, in addition to their restricted polymorphism, might account for the unusual susceptibility of the cotton-top tamarin to human pathogens.