gebhart/patrepeval huggingface dataset:
Direct Preparation of Allylstannanes from Allyl Alcohols: Convenient Synthesis of β-Substituted Allylstannanes and of Stereodefined γ-Substituted Allylstannanes (1996)

Primary allyl alcohols are converted into allyltributylstannanes in a one-pot operation. It entails (i) deprotonation with BuLi, (ii) sulfonylation with mesyl chloride, and (iii) nucleophilic substitution by LiSnBu3. Conversions are quantitative with isolated yields ranging from 70% to 100%. If the starting allyl alcohol contains a stereogenic double bond its configuration is retained.
Covalent crosslinking of human chorionic gonadotropin to its receptor in rat testes. (1981)

The bifunctional crosslinking reagents disuccinimidyl suberate and dithiobis(succinimidyl propionate) were used to attach 125I-labeled human chorionic gonadotropin (125I-hCG) covalently to rat testicular membranes. The extent of crosslinking was dependent on time and concentration; routinely, 30% of the specifically bound hormone was covalently linked to the membranes in the presence of 0.5 mM crosslinking reagent when incubated at 25 degrees C for 15 min. Excess unlabeled hCG blocked the crosslinking of 125I-hCG to the membranes. When solubilized with Triton X-100 and analyzed by sucrose density gradient centrifugation, both the native and the crosslinked hormone-receptor complex sedimented with an apparent Mr of 220,000. Thus, the receptor itself would have Mr 180,000. When the crosslinked complex was analyzed by sodium dodecyl sulfate/polyacrylamide gel electrophoresis, the predominant species had a Mr of 123,000 and appeared to represent the labeled alpha subunit of hCG covalently linked to a membrane component. The Mr of this receptor component would be 100,000, a value approximately half that of the Triton X-100-solubilized receptor. Thus, the membrane receptor for hCG may consist of a dimer of two binding subunits or a binding subunit associated with one or more additional subunits that might play a coupling or regulatory function.
Production of linear polymers of HIV go120-binding domains (1994)

It has been demonstrated previously that molecular decoys of the acetylcholine receptor have therapeutic efficacy as antitoxins [Gershoni, J. and Aronheim, A. (1988) Proc. Natl Acad. Sci. USA, 85, 4087-4089], but surely a most challenging goal is to apply this approach towards the development of antiviral drugs. As viruses present multiple copies of their envelope proteins, it was proposed that polyvalent decoys could be advantageous. Here we report the design and expression of recombinant linear polymers of the HIV gp120-binding domains which are situated within the T-cell membrane protein CD4. Whereas the production of linear concatemers of CD4 variable domains is feasible, a number of conformational constraints must be considered when designing a polymeric molecule which retains biological function. Most significant is the contribution of domains flanking the binding site that apparently enable correct folding of the latter.
MRI brain image segmentation using an AM-FM model (2002)

MRI brain images are characterized by non-stationary components that make fully automated segmentation a challenging task. An AM-FM model is used to model these non-stationarities. Using the AM-FM model, a new, fully automated texture segmentation system is used to automatically segment the cerebellum from a 3-D set of MRI brain images.
Heat Distribution in the Spinal Canal during Radiofrequency Ablation for Vertebral Lesions: Study in Swine (2008)

For in vivo cases with a 2-cm active tip and ex vivo cases with a vertebral posterior bone defect, the temperature rose to over 45 degrees C, potentially injuring the spinal cord and peripheral nerves.
Modifying TNF alpha for Therapeutic Use A Perspective on the TNF Receptor System (2001)

TNFalpha is an inflammatory mediator that is relevant to several autoimmune diseases. Macromolecular inhibitors of TNFalpha have proven therapeutically useful in some preliminary studies. We have developed small molecule TNFalpha antagonist based on the crystal structure of TNF receptor complex. The TNFalpha inhibitor is specific and mediates biological function similar to the inhibitory soluble TNF receptor. This review focuses on development of small molecule anti-TNFalpha mimetics by us and current status of other agents.
N-Heterocyclic phosphenium cations: syntheses and cycloaddition reactions (2008)

A series of trifluoromethanesulfonate (OTf) salts of N-heterocyclic phospheniums (NHP) bearing phenyl (1a), para-methoxyphenyl (1b), 2,6-diisopropylphenyl (1c) and mesityl (1d) substituents is reported. The compounds are made by a modification to a literature procedure that improves the overall yields for and by 15 and 23%, respectively. Two unwanted side-products in the synthesis of , the diammonium salt, [(2,6-iPr-C6H3)N(H)2CH2CH2N(H)2(2,6-iPr-C6H3)]Cl2 (4) and the bisphosphine (2,6-iPr-C6H3)N(PCl2)CH2CH2N(PCl2)(2,6-iPr-C6H3) (5), are crystallographically characterized, as is the intermediate cyclic chlorophosphine, C1PN(4-OMe-C6H4)CH2CH2N(4-OMe-C6H4) (3b). The phenyl-substituted NHP is fully characterized, including by X-ray crystallography, for the first time; this compound contains a short P-O contact of 2.1850(14) A. Cycloaddition reactions of with 2,3-dimethyl-1,3-butadiene give the expected spirocyclic phospholeniums, 7,8-dimethyl-1,4-diaryl-1,4-diaza-5-phopshoniaspiro[4.4]non-7-ene, as their OTf salts (6a-d), while reactions with N,N'-dimesityl-1,4-diaza-1,3-butadiene give, except in the case of , which is too bulky to react, the aza analogues, 1,4-dimesityl-6,9-diaryl-1,4,6,9-tetraaza-5-phosphoniaspiro[4.4]non-2-ene (7a, 7b and 7d). The sterically congested is in thermal equilibrium with and free diazadiene, and undergoes a substitution reaction with 2,3-dimethyl-1,3-butadiene to give .
Effects of <i>trans</i> -Resveratrol from <i>Polygonum cuspidatum</i> on Bone Loss Using the Ovariectomized Rat Model (2005)

trans-Resveratrol (resveratrol) has been shown in several studies to significantly modulate biomarkers of bone metabolism. But, there is no direct evidence supporting its inhibitory effect towards bone loss. In the present study, effects of resveratrol on bone mineral density (BMD) and bone calcium content (BCC) were examined in the ovariectomized (OVX) rat model. Female Wistar rats were divided into four groups: SHAM group (sham-operated), OVX group (OVX control), OVX + ALD group (OVX and treated with 1.0 mg/kg of body weight of alendronate sodium), and OVX + RES group (OVX and treated with 0.7 mg/kg of body weight of resveratrol). Tested materials were given by gavage for 12 weeks after ovariectomy. Results showed that rats in the OVX, OVX + ALD, and OVX + RES groups had significantly higher body weights and feed efficiency than those in the SHAM group (P < .01). The OVX group had significantly lower femoral epiphysis BMD than the SHAM group, and epiphysis BMD in the OVX + ALD and OVX + RES groups was significantly greater than that in the OVX group (P < .05). However, the femoral midpoint BMD was not significantly different among the four groups. Additionally, animals in the OVX group had significantly lower BCC compared with the SHAM group, while the BCC of the OVX + ALD and OVX + RES groups was significantly higher than that of the OVX group (P < .05). These results indicated that resveratrol could increase epiphysis BMD and inhibit the decrease of femur BCC in OVX rats, suggesting that it could play a role in protecting against bone loss induced by estrogen deficiency.
Variation in the protein composition of bovine casein micelles and serum casein in relation to micellar size and milk temperature (1983)

Summary The caseinate complex in bovine milk was partitioned by differential centrifugation at both 20 and 4 °C into 4 micellar fractions and a fraction representing serum casein, and the protein composition of the fractions determined. At both temperatures the relative amount of κ-casein in the micellar caseins increased markedly and that of β-casein decreased appreciably with decreasing micelle size. The relative amount of α s2 -casein also tended to decrease with decreasing micelle size, but the relative amounts of α s1 - and γ-caseins, and an unidentified casein fraction, showed little systematic variation. The serum casein differed appreciably in composition from the micellar caseins, being very rich in β-casein and comparatively poor in α sl - and α s2 -caseins, and the amount present at 4 °C was considerably greater than at 20 °C, with the increase being due almost entirely to β-casein, but with γ-casein also making a significant contribution. The changes in the composition and distribution of micellar and serum caseins induced by cooling milk at 4 °C were completely reversible when the milk was re-equilibrated at 20 °C for 18 h.
A Big Data Fuzzy Grey Relational Analysis Method for social post retrieval - with an application to Facebook's news groups (2017)

In social media, after many candidate posts are chosen by satisfying functional criteria of target posts, users require a selection algorithm to further rank the candidate posts with their nonfunctional criteria. Therefore, this study proposes a novel algorithm, named BD-FGRA (Big Data-Fuzzy Grey Relational Analysis), to handle posts on parallel over the Spark platform by selecting the top-N posts that satisfy all the user-specified selection criteria, the ranking criteria and the goals of the nonfunctional attributes most. All the experiments show that BD-FGRA gets convincing performances.
Cyclic variation in myocardial gray level as a marker of viability in man: A videodensitometric study (1996)

Experimental and human studies have shown that a preserved cyclic (diastolic-to-systolic) echoreflectivity variation, assessed by radiofrequency sampling of backscatter signal with non-commercially available prototypes, identifies viability in a myocardial segment with a resting dyssynergy. The objective of this study was to assess whether a videodensitometric analysis of myocardial gray level variation during cardiac cycle might identify viable but dyssynergic myocardium in a clinical setting. Thirty-four patients with a resting dyssynergy (akinesis in 26, marked hypokinesis in eight) in the septum and/or inferno-posterior wall were evaluated by videodensitometry. All echo studies were performed with commercially available instruments in the long axis parasternal view, with quantitative analysis of gray levels performed off-line on digitized images. Segmental wall motion was assessed with a 16 segment model of the left ventricle, each scored from 1, normal, to 4, dyskinetic. A follow-up echo study was obtained in all patients > 4 weeks after successful revascularization (in 22 by angioplasty, in 12 by bypass surgery). Two groups of segments were identified: 18 viable segments (contractile improvement of 1 grade or more in resting function after revascularization); 16 necrotic segments (no contractile improvement in resting function after revascularization). The % cyclic variation was higher in viable vs necrotic segments (26 +/- 16 vs 1 +/- 13%, P < 0.01), in spite of similar % systolic thickening (5 +/- 5 vs 4 +/- 6%, P = ns) and end-diastolic thickness (10 +/- 2 vs 10 +/- 2 mm, P = ns). When individual patient analysis was performed, % cyclic variation was below the 95% confidence limits obtained from normal control regions (n = 34; % cyclic variation = 38 +/- 14) in two out of 18 viable and in 14 out of 16 necrotic segments. A cut-off of > or = 9.4% cyclic variations in a dyssynergic segment yielded 89% sensitivity and 88% specificity for predicting functional recovery following successful revascularization. In conclusion, viable dyssynergic myocardial segments show a cyclic gray level variation at rest, which can be detected by simple videodensitometric analysis, much less technologically demanding than radiofrequency backscatter evaluation.
Study on 3D shape and deformation measurement of a radiator fan based on high-speed binary defocused fringe projection (2016)

The binary defocused fringe can overcome the nonlinear effect of an ordinary commercial digital projector and generate a good sinusoidal light field. In this paper, the binary fringe encoding method was chosen to complete the high-speed fringe projection using a DLP Lightcrafter 4500 model in dynamic Fourier transform profilometry, and then a camera was synchronously triggered to record the deformation fringes on the surface of a high-speed rotating radiator fan, whose time-changing 3D surface shape was reconstructed with Fourier fringe analysis. Further deformation analysis of the measured radiator fan blade and rotating shaft is helpful to improve the performance of the radiator. The experimental results on a tested radiator fan with the rotation speed of 4800rpm identified the validity of the presented setup, and this method can effectively expand the application of dynamic 3D shape measurement.
Hair growth-promoting activity of hot water extract of Thuja orientalis (2013)

These results suggest that T. orientalis extract promotes hair growth by inducing the anagen phase in resting hair follicles and might therefore be a potential hair growth-promoting agent.
<title>Visual hash for oblivious watermarking</title> (2000)

Digital watermarks have recently been proposed for authentication and fingerprinting of both video data and still images and for integrity verification of visual multimedia. In such applications, the watermark must be oblivious and has to depend on a secret key and on the original image. It is important that the dependence on the key be sensitive, while the dependence on the image be continuous (robust). Both requirements can be satisfied using special image digest (hash) functions that return the same bit-string for whole class of images derived from an original image using common processing operations including rotation and scaling. It is further required that two completely different images produce completely different bit-strings. In this paper, we extend our previous work on robust image digest functions describing ideas how to make the hash function independent of image orientation and size. The robust image digest can be clearly utilized for other applications, such as a search index for an efficient image database search.
A macrophage receptor for liver lysosomal .BETA.-glucosidase. (1988)

beta-Glucosidase was purified from lysosomal membranes isolated from rat liver. Binding and uptake of the purified beta-glucosidase were mediated via an apparently single binding site on rat peritoneal macrophages. The number of sites and the Kd were 4.20 X 10(4)/cell and 1.00 X 10(-7) M, respectively. Neither of the processes was inhibited by ligands for mannose/fucose receptors, mannose 6-phosphate receptors, or scavenger receptors, or by other glycoproteins and sugar compounds. A portion of the beta-glucosidase taken up into the macrophages was degraded rapidly. These results suggested that liver lysosomal beta-glucosidase was endocytosed via a receptor not previously described.
Immunoproteasomes Down-Regulate Presentation of a Subdominant T Cell Epitope from Lymphocytic Choriomeningitis Virus (2004)

The cytotoxic T cell response to pathogens is usually directed against a few immunodominant epitopes, while other potential epitopes are either subdominant or not used at all. In C57BL/6 mice, the acute cytotoxic T cell response against lymphocytic choriomeningitis virus is directed against immunodominant epitopes derived from the glycoprotein (gp33-41) and the nucleoprotein (NP396-404), while the gp276-286 epitope remains subdominant. Despite extensive investigations, the reason for this hierarchy between epitopes is not clear. In this study, we show that the treatment of cells with IFN-gamma enhanced the presentation of gp33-41, whereas presentation of the gp276-286 epitope from the same glycoprotein was markedly reduced. Because proteasomes are crucially involved in epitope generation and because IFN-gamma treatment in vitro and lymphocytic choriomeningitis virus infection in vivo lead to a gradual replacement of constitutive proteasomes by immunoproteasomes, we investigated the role of proteasome composition on epitope hierarchy. Overexpression of the active site subunits of immunoproteasomes LMP2, LMP7, and MECL-1 as well as overexpression of LMP2 alone suppressed the presentation of the gp276-286 epitope. The ability to generate gp276-286-specific CTLs was enhanced in LMP2- and LMP7-deficient mice, and macrophages from these mice showed an elevated presentation of this epitope. In vitro digests demonstrated that fragmentation by immunoproteasomes, but not constitutive proteasomes led to a preferential destruction of the gp276 epitope. Taken together, we show that LMP2 and LMP7 can at least in part determine subdominance and shape the epitope hierarchy of CTL responses in vivo.
Autonomous humanoid robot navigation using augmented reality technique (2011)

This work presents a novel vision-based navigation strategy for autonomous humanoid robots using augmented reality (AR). In the first stage, a platform is developed for indoor and outdoor human location positioning and navigation using mobile augmented reality. The image sequence would be obtained by a smart phone's camera and the location information will be provided to the user in the form of 3D graphics and audio effects containing location information. To recognize a location, an image database and location model is pre-constructed to relate the detected AR-marker's position to the map of environment. The AR-markers basically act as active landmarks placed in undiscovered environments, sending out location information once detected by a camera. The second stage implements the same algorithm on an autonomous humanoid robot to be used as its navigation module. This is achieved by coupling the robot odometry and inertial sensing with the visual marker detection module. Using this system, the robot employs its vision system to enhance its localization robustness and allow quick recovery in lost situations by detecting the active landmarks or the so called AR-markers. The problem of motion blur resulting from the 6-DOF motion of humanoid's camera is solved using an adaptive thresholding technique developed to increase the robustness of the augmented reality marker detection under different illumination conditions and camera movements. For our experiments, we used the humanoid robot NAO and verified the performance of this navigation methodology in real-world scenarios.
Performance of Activated Carbon in Evaporative Loss Control Systems (1990)

<div class="htmlview paragraph">Although activated carbons have been used successfully for approximately 20 years for control of hydrocarbon evaporative emissions from motor vehicles, the correlation of fundamental activated carbon properties, molecular scale pore size/volume characteristics, to carbon performance has not generally been available. Improvements in wood-based carbon have focused on the pore size/volume characteristics resulting in a doubling of performance, as measured by butane working capacity, over the past few years. In addition to relating the butane working capacity for different types of carbon to pore characteristics, laboratory studies using new carbons have demonstrated that the capacity for adsorption of vapors from gasoline is also related to this fundamental property. Furthermore, different types of in-use carbons from vehicle canisters have been evaluated to confirm that the key to carbon performance is pore characteristics and also, that laboratory evaluations of carbons, using proper conditions, can realistically simulate the performance of actual in-use carbons.</div>
Characterization by monoclonal antibodies of a target cell antigen complex recognized by nonspecific cytotoxic cells. (1988)

Fish nonspecific cytotoxic cells (NCC)3 recognize and lyse a large variety of human and mouse transformed cells. In an effort to determine the Ag recognized by NCC on these targets, mAb were raised against NC-37 target cells. Four anti-NC-37 mAb were chosen for further characterization based on their effects on NCC lysis of target cells. Purified mAb 18C2 and 1E7 (IgM isotype) inhibited NCC killing of the following targets: U937, MOLT-4, K562, HL-60, DAUDI, NC-37, P815, and YAC-1. The dose-dependent inhibitory activity occurred at the target cell level and ranged from 50 to 70% at a concentration of 50 micrograms/well when compared to noninhibitory mAb 7C6 and 1D4 (IgG isotype). Similarly, mAb 18C2 protected the fish parasite Tetrahymena pyriformis from lysis by NCC when compared to mAb 7C6. Adsorption experiments demonstrated that the inhibitory effect on NC-37 lysis by NCC could be removed in a titratable fashion by incubation of mAb 1E7 with any one of the other target cell lines, but it could not be removed by incubation with effector cells. The inhibitory activity of mAb 1E7 and 18C2 was shown to be caused by the inhibition of conjugate formation between effector and NC-37 target cells. The relative membrane concentration of the antigenic determinants recognized by these mAb on the target cells was studied by flow cytometry using FITC-labeled mAb. These experiments showed that all four mAb bound to the surface of the cells tested. Biochemical analysis with Western blots and immunoprecipitation showed that mAb 18C2 and 1E7 recognize two Ag in NC-37 lysates: a larger protein of around 80 kDa and a smaller one of 42 kDa.
An Efficient and Practical Protocol for Catalytic Hydrolysis of Nitriles by a Copper(I) Complex in Water (2012)

Abstract The cuprous complex – Cu 4 I 4 (H 2 O) 4 – has been isolated and employed for the catalytic hydrolysis of arenecarbonitriles, cinnamonitrile, and arylacetonitriles to the corresponding amides in pure water in high yields of up to 98%. The catalyst can be easily recovered and reused without loss of catalytic activity at least five times. Oxindole could be prepared successfully by one‐pot domino protocols based on this method.
Norovirus Infections Occur in B-Cell–Deficient Patients: Table 1. (2016)

Norovirus incidence was compared between severe combined immunodeficiency children with (n = 10) and without (n = 8) B cells. 60% of B+ and 63% of B- patients developed norovirus infections therefore norovirus replication in B lymphocytes is not essential for infection.
AdaptiviTree: Adaptive Tree Visualization for Tournament-Style Brackets (2007)

Online pick'em games, such as the recent NCAA college basketball March Madness tournament, form a large and rapidly growing industry. In these games, players make predictions on a tournament bracket that defines which competitors play each other and how they proceed toward a single champion. Throughout the course of the tournament, players monitor the brackets to track progress and to compare predictions made by multiple players. This is often a complex sensemaking task. The classic bracket visualization was designed for use on paper and utilizes an incrementally additive system in which the winner of each match-up is rewritten in the next round as the tournament progresses. Unfortunately, this representation requires a significant amount of space and makes it relatively difficult to get a quick overview of the tournament state since competitors take arbitrary paths through the static bracket. In this paper, we present AdaptiviTree, a novel visualization that adaptively deforms the representation of the tree and uses its shape to convey outcome information. AdaptiviTree not only provides a more compact and understandable representation, but also allows overlays that display predictions as well as other statistics. We describe results from a lab study we conducted to explore the efficacy of AdaptiviTree, as well as from a deployment of the system in a recent real-world sports tournament.