gebhart/patrepeval huggingface dataset:
The synthetic retinoid RO 13‐6307 induces neuroblastoma differentiation <i>in vitro</i> and inhibits neuroblastoma tumour growth <i>in vivo</i> (2003)

Abstract Retinoids modulate cell proliferation, differentiation and apoptosis in a variety of tumour cells including leukaemia and neuroblastoma, a childhood tumour of the sympathetic nervous system. 13‐ cis retinoic acid is in clinical use against minimal residual disease in neuroblastoma, where the effect seems to depend on dose, scheduling and tumour mass. Novel retinoids are searched for, to improve potency and lower toxicity. We investigated the effect of the synthetic retinoid Ro 13‐6307 on neuroblastoma growth in vitro on SK‐N‐BE(2) and SH‐SY5Y cells. Furthermore, effects on tumour growth and the toxicity profile were investigated in a rat xenograft model. Effects of Ro 13‐6307 were compared to 13‐ cis RA (retinoic acid) in vitro and in vivo . Neuroblastoma cells treated with 1 μM Ro 13‐6307 exhibited neuronal differentiation, decreased proliferation and accumulation of cells in G1 phase in at least the same magnitude as 5 μM 13‐ cis RA. No apoptosis was detected in vitro . Treatment of nude rats with neuroblastoma using Ro 13‐6307, 0.12 mg p.o. daily, decreased neuroblastoma growth in vivo , in terms of tumour volume during treatment and tumour weight at sacrifice ( p < 0.05). In contrast, Ro 13‐6307, 0.08 mg p.o. daily, resulted in no significant reduction in tumour growth. All rats treated with Ro 13‐6307 gained less weight than control rats, but they exhibited no other signs of toxicity. The toxicity profile of Ro 13‐6307 was similar to what we found with 13‐ cis RA. Our preclinical results suggest that Ro 13‐6307 may be a candidate retinoid for clinical oral therapy of neuroblastoma in children. © 2003 Wiley‐Liss, Inc.
Differential Biodistribution of Adenoviral Vector <i>In Vivo</i> as Monitored by Bioluminescence Imaging and Quantitative Polymerase Chain Reaction (2006)

A better understanding of the in vivo biodistribution of adenoviral vectors would enable the researcher to anticipate potential side effects due to off-targeted site of transduction, and aid in the strategic design of gene therapy. We combined real-time polymerase chain reaction with in vivo optical imaging to examine viral transduction in liver, lung, spleen, kidney, prostate, and lymph nodes. A replication-deficient serotype 5 adenoviral vector expressing the firefly luciferase gene under the control of a constitutive cytomegalovirus promoter was administered in vivo via different routes. Intravenous and intraperitoneal injections resulted in greatest gene expression and viral DNA in the liver, whereas intraperitoneal injections led to a greater extent of gene delivery to the prostate. Although prostate-directed injection resulted in dominant gene expression in the targeted site, leakage of the vector to other organs was also observed. Vector injection into the lymphatic-rich paw tissue or the subcutaneous tissue of shoulder or chest followed the expected lymphatic drainage pattern, resulting in the accumulation of viral vector in ipsilateral brachial and axillary lymph nodes. Collectively, this study demonstrates that each tissue retains various amounts of adenoviral vector, depending on the route of administration. This knowledge is useful in the strategic design and implementation of adenovirus-mediated gene therapies.
Junction-Less Stackable SONOS Memory Realized on Vertical-Si-Nanowire for 3-D Application (2011)

This study presents vertical Si-nanowire (SiNW) gate all-around (GAA) non-volatile memory with channel diameter down to 20nm. The junction-less devices with SiN trap layer is found to have comparable memory characteristics (3.2V in 1ms P/E at +15V/-16V) to the junction-based cell. Despite of that, the absence of junctions reduces the process complexity and makes vertical SiNW a suitable platform for multi-level stacked ultra high density memory application.
Innovation in practice at Walsgrave Hospital (1997)

This report highlights some of the innovative practice of nurses and therapists working at Walsgrave Hospital NHS Trust
3D sparse feature model using short baseline stereo and multiple view registration (2011)

\n\t\t\t\t\tThis paper outlines a methodology to generate a distinctive object representation offline, using short-baseline stereo fundamentals to triangulate highly descriptive object features in multiple pairs of stereo images. A group of sparse 2.5D perspective views are built and the multiple views are then fused into a single sparse 3D model using a common 3D shape registration technique. Having prior knowledge, such as the proposed sparse feature model, is useful when detecting an object and estimating its pose for real-time systems like augmented reality.\n\t\t\t\t
L-aspartate improves the functional recovery of explanted hearts stored in St. Thomas' Hospital cardioplegic solution at 4 degrees C. (1990)

Explanted rat hearts were subjected to cardioplegic arrest by 3 minutes' perfusion with oxygenated St. Thomas' Hospital solution no. 2 and then were stored by immersion in the same solution at 4 degrees C. Prearrest and postischemic left ventricular functions were compared by means of an isolated working heart apparatus. Hearts (n = 8 per group) arrested and stored for up to 8 hours all resumed the spontaneous rhythm of contraction during reperfusion for 30 minutes at 37 degrees C. There was good recovery of aortic flow rate (105% +/- 3%) against a pressure of 100 cm H2O, of heart rate (102% +/- 2%), and of aortic pressure (86% +/- 5% of prearrest values). Hearts stored for 10 and 20 hours showed poor or no postischemic recovery of cardiac pump function (aortic flow, 16% +/- 11% and 0%, respectively). Enrichment of St. Thomas' Hospital solution with L-glutamate (20 mmol/L) also failed to improve functional recovery of hearts subjected to 10 hours of storage, but hearts treated with St. Thomas' Hospital solution containing L-aspartate (20 mmol/L) or L-aspartate plus L-glutamate (20 mmol/L each) reestablished aortic flow rates of 99% +/- 5% and 93% +/- 4%, respectively. These results indicate that the addition of L-aspartate to St. Thomas' Hospital solution improves the functional recovery and extends the safe preservation of explanted hearts stored at 4 degrees C.
Origin of Stripe Domains in Ni–Fe Films (1967)

Stripe domains have been observed in Ni–Fe films having positive, zero, or negative magnetostriction and with either tensile or compressive stress. By using the model of Saito et al. and assuming their anisotropy constant K is attributed to both the shape anisotropy K0 and the magnetostrictively induced anisotropy Ks, we can explain our experimental results quantitatively. Here K0 and Ks are determined from the stress, the magnetostriction and the geometry of a columnar grain structure (defined by Iwata et al.). From a critical thickness (the minimum thickness above which the stripe domains will be formed) vs film composition curve, it has been found that K0 is about an order of magnitude larger than Ks at a composition of 85% Ni. Therefore, the shape anisotropy, especially in the neighborhood of 81.7% Ni, is determined as the predominant factor in the perpendicular anisotropy which causes formation of stripe domains. Dependence of stripe domains on annealing, film thickness, substrate temperature, and vacuum pressure during film deposition further supports our conclusion.
Fluoroquinolone Resistance in <i>Streptococcus pneumoniae</i> : Area Under the Concentration-Time Curve/MIC Ratio and Resistance Development with Gatifloxacin, Gemifloxacin, Levofloxacin, and Moxifloxacin (2007)

The potential for resistance development in Streptococcus pneumoniae secondary to exposure to gatifloxacin, gemifloxacin, levofloxacin, and moxifloxacin at various levels was examined at high inoculum (10(8.5) to 10(9) log10 CFU/ml) over 96 h in an in vitro pharmacodynamic (PD) model using two fluoroquinolone-susceptible isolates. The pharmacokinetics of each drug was simulated to provide a range of free areas under the concentration-time curves (fAUC) that correlated with various fluoroquinolone doses. Potential first (parC and parE)- and second-step (gyrA and gyrB) mutations in isolates with raised MICs were identified by sequence analysis. PD models simulating fAUC/MICs of 51 and<or=60, 34 and 37, <or=82 and<or=86, and<or=24 for gatifloxacin, gemifloxacin, levofloxacin, and moxifloxacin, respectively, against each isolate were associated with first-step parC (S52G, S79Y, and N91D) and second-step gyrA (S81Y and S114G) mutations. For each fluoroquinolone a delay of first- and second-step mutations was observed with increasingly higher fAUC/MIC ratios and recovery of topoisomerase mutations in S. pneumoniae was related to the fAUC/MIC exposure. Clinical doses of gatifloxacin, gemifloxacin, and moxifloxacin exceeded the fAUC/MIC resistance breakpoint against wild-type S. pneumoniae, whereas those of levofloxacin (500 and 750 mg) were associated with first- and second-step mutations. The exposure breakpoints for levofloxacin were significantly different (P<0.001) from those of the newer fluoroquinolones gatifloxacin, gemifloxacin, and moxifloxacin. Additionally, moxifloxacin breakpoints were significantly lower (P<0.002) than those of gatifloxacin. The order of resistance development determined from fAUC/MIC breakpoints was levofloxacin>gatifloxacin>moxifloxacin=gemifloxacin, which may be related to structural differences within the class.
Effect of waveguide optical scattering on the integrated optical spectrum analyzer dynamic range (1978)

The dynamic range limited by optical scattering in the integrated optical spectrum analyzer is considered. Calculations of dynamic range as a function of waveguide attenuation and surface roughness characteristics are presented. Dynamic range is found to decrease with increasing attenuation, to be nearly independent of the surface roughness correlation length for a fixed attenuation, and to be independent of the Fourier transform lens focal length. Adjacent channel rejection is found to fall off slowly. The effect of lens scattering is shown only to be important for cases in which waveguide scattering is very small and lens scattering is very high.
Risk Factors for Carotid Atherosclerosis: The Kuopio Ischaemic Heart Disease Risk Factor Study (1989)

We assessed the severity of carotid atherosclerosis in 412 men from eastern Finland aged 42, 48, 54 or 60 years at examination with B-mode ultrasonography in 1987 in the Kuopi ischaemic Heart Disease Risk Factor Study (KIHD). Thirty-seven per cent of participants had intimal-medial thickening, 10% had plaques and 2% had stenosis. Age (P less than 0.001), cigarette-years (P less than 0.001), serum LDL cholesterol (P = 0.005), low income (P = 0.020) and low alcohol consumption (P = 0.048) had significant partial associations with the severity of carotid atherosclerosis. A linear regression model including these variables and plasma fibrinogen (NS) and serum HDL-cholesterol (NS) accounted for 33% of the variation in atherosclerosis severity. Our data provide further evidence on the role of smoking and LDL-cholesterol in atherosclerosis.
Excited-state intramolecular proton transfer in 3-hydroxylflavone isolated in solid argon: fluoroescence and fluorescence-excitation spectra and tautomer fluorescence rise time (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExcited-state intramolecular proton transfer in 3-hydroxylflavone isolated in solid argon: fluoroescence and fluorescence-excitation spectra and tautomer fluorescence rise timeBernhard. Dick and Niko P. ErnstingCite this: J. Phys. Chem. 1987, 91, 16, 4261–4265Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/j100300a012https://doi.org/10.1021/j100300a012research-articleACS PublicationsRequest reuse permissionsArticle Views467Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A Blind $I/Q$ Imbalance Compensation Technique for Direct-Conversion Digital Radio Transceivers (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Although the quadrature mixing radio front-end offers an attractive way to perform frequency translation, its image-rejection capability is severely affected by the gain and phase imbalances (<formula formulatype="inline"><tex Notation="TeX"> $I/Q$</tex></formula> imbalances) between its two analog signal paths. Digital signal processing techniques have widely been proposed to compensate for these mixer imperfections. Of these techniques, the class of blind compensation techniques seems very attractive since no test signals are required. This paper presents a novel <formula formulatype="inline"><tex Notation="TeX">$I/Q$</tex></formula> imbalance extraction technique that uses a Cholesky decomposition of the received signal's covariance matrix to extract the exact imbalances of the front-end. An analysis is also presented on extracting and separating the imbalances of a cascaded imbalanced modulator and demodulator. Both a block-based and an adaptive variant of the technique are proposed, and a performance evaluation over multipath channels is presented. </para>
Approaching microtubule structure with the scanning tunneling microscope (STM) (1994)

We demonstrate that the scanning tunneling microscope can be used to obtain information about arrangement of tubulin subunits in the microtubule wall. Long rows of subunits with a periodicity of 3.8 +/- 0.4 nm were clearly visible in the images of microtubules. The separation between the rows of subunits was 4.8 +/- 0.4 nm. Close inspection of two images revealed another periodicity of 7.8 +/- 0.4 nm in the contour levels of the protofilaments. This indicates that alpha and beta tubulin monomers can be resolved. In these areas the monomers were arranged according to a 'B-type' lattice. Scanning tunneling microscope images confirm that the lateral contacts between tubulin monomers in adjacent protofilaments are compatible with a three-start, left-handed helix model. This study demonstrates that scanning tunneling microscopy can give direct information on the structure and organization of macromolecular assemblies and can complement the classical methods of electron microscopy and X-ray scattering.
An experimental comparison between several pneumatic position control methods (2003)

In this paper an experimental comparison is made between six different techniques to control the position of a pneumatic actuator. Six different reference signals have been tested on each control technique. The methods considered are: (A) PID, (B) fuzzy, (C) PID with pressure feedback, (D) fuzzy with pressure feedback, (E) sliding mode and (F) neuro-fuzzy control. In the last method, proposed by the authors, the differential pressure sensor has been replaced by a neural network based estimator. Details of each control method and the results obtained are given and finally a global comparison is made with several critical considerations.
Back-propagation neural network for nonlinear self-tuning adaptive control (2003)

A backpropagation neural network is applied to a nonlinear self-tuning tracking problem. Traditional self-tuning adaptive control techniques can only deal with linear systems or some special nonlinear systems. The emerging backpropagation neural networks have the capability to learn arbitrary nonlinearity and show great potential for adaptive control applications. A scheme for combining backpropagation neural networks with self-tuning adaptive control techniques is proposed. The control mechanism is analyzed. Simulation results show that the new self-tuning scheme can deal with a large unknown nonlinearity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pollen movement to two male-sterile soybean mutants grown in two locations (1983)

Journal Article Pollen movement to two male-sterile soybean mutants grown in two locations Get access Reld G. Palmer, Reld G. Palmer research geneticist, USDA-ARS, Department or Agronomy, Iowa State UniversityAmes, Iowa 50011 Search for other works by this author on: Oxford Academic PubMed Google Scholar Marc C. Albertsen, Marc C. Albertsen research cytogeneticist, Pioneer Hi-Bred International, Inc., Box 38, Johnston, Iowa 50131 Search for other works by this author on: Oxford Academic PubMed Google Scholar Carol W. Johns Carol W. Johns graduate fellow, Texas A & M University, Department of Soil and Crop SciencesCollege Station, Texas 77843 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 74, Issue 1, January 1983, Pages 55–57, https://doi.org/10.1093/oxfordjournals.jhered.a109719 Published: 01 January 1983
Modern Image-Guided Intensity-Modulated Radiotherapy for Oropharynx Cancer and Severe Late Toxic Effects (2016)

These results suggest that severe late toxic effects after modern definitive IG-IMRT, with or without cisplatin, for oropharynx cancer is likely uncommon. The importance of late toxic effect reduction in current and future investigational strategies, including clinical trials, should be considered.
La mujer futbolista desde la perspectiva psicológica (2003)

En los ultimos anos se constata un aumento de la practica del futbol por parte de la mujer. Este hecho demanda analisis desde las diferentes areas cientificas, desde las que se aborda el hecho deportivo. En este trabajo se pretende esbozar algunas de las cuestiones mas relevantes, tanto desde el campo aplicado de la psicologia, como de la intervencion especifica. Se propone discutir acerca de las potenciales diferencias de genero respecto al perfil psicologico del deportista. Se plantean algunas diferencias entre chicos y chicas jovenes futbolistas respecto a procesos motivacionales. Y, por ultimo, se presenta el entrenamiento psicologico que se realiza con el equipo femenino del Rayo Vallecano de Madrid S.A.D.
Comparative study of SiO_2, Si_3N_4 and TiO_2 thin films as passivation layers for quantum cascade lasers (2016)

The aim of this article is to determine the best dielectric between SiO<sub>2</sub>, Si<sub>3</sub>N<sub>4</sub> and TiO<sub>2</sub> for quantum cascade laser (QCL) passivation layers depending on the operation wavelength. It relies on both Mueller ellipsometry measurement to accurately determine the optical constants (the refractive index n and the extinction coefficient k) of the three dielectrics, and optical simulations to determine the mode overlap with the dielectric and furthermore the modal losses in the passivation layer. The impact of dielectric thermal conductivities are taken into account and shown to be not critical on the laser performances.
Research of Domestic Stock Fractal Characteristic Based On R/S Method (2008)

In the stock market has the massive fractal characteistics,the stock market income also obeys the fractal distribution,displays for has the peak.the width tail characteristic in the average value place.The article uses R/S analytic method this article selects the Chinese source stock(code 600656) the date closing price sequence is the sample data,carries on the fitting as well as the realization control chart monitoring process to the stock undulation,obtains the following conclusion stock the returns ration is not walks randomly stochastically,but is one has leaning walks randomly stochastically,does not belong to the effective market which EMH describes.The stock returns ration sequence has the endurance,has the fractal characteristic,also has an average length of the cycle is 115 say-long long-term memories.
Photovoltaics in Buildings: A Design Handbook for Architects and Engineers (1996)

The integration of photovoltaics (PV) into buildings goes beyond energy saving by providing a clean and elegant way of actually generating electricity. There are already numerous successful examples and rapid technological improvements promise expansion of PV's present niche market to that of a major energy provider of the 21st century.

This handbook is the outcome of a five year programme which took place under the auspices of the International Energy Agency. Architects and solar experts from 13 countries addressed the wide range of engineering and architectural issues involved in the successful integration of PV into buildings.

It demonstrates how to maximise the overall solar contribution to the building; integrate PV effectively with the building structure; clarify the relationship of PV with other elements of the building's energy system; optimise the system economics.

It forms a thorough design guide that covers all aspects if the subject and will enable all building designers, engineers and property owners to make the integration of PV into buildings an architecturally appealing and energetically effective option.
El tratamiento de aguas por radiación ultravioleta en la industria de bebidas (2000)

La desinfeccion es uno de los puntos basicos del tratamiento de potabilizacion de aguas. El empleo sistematico de sustancias quimicas (cloro y sus derivados), y mas recientemente la radiacion UV ha hecho descender de forma espectacular la existencia de microorganismos en las aguas para embotellado y de uso industrial. El objeto del presente articulo es recordar de una forma generalizada el mecanismo de actuacion de la radiacion UV e indicar cuales son las ventajas e inconvenientes del uso de esta tecnica en la industria de bebidas.
Influence of surface effects on the characteristic curves of detergent sensors (2012)

The dynamic investigation of detergent properties during a washing process requires a sensitive measuring procedure, e.g. impedance spectroscopy. High selectivity and reproducibility are necessary to understand these properties. To keep down cross-sensitivity and interference, high requirements are demanded from the sensor element. The aims are to develop a sensor element which fulfills these requirements and to investigate the side-effects. Unavoidable cross-sensitivities and interferences will be described and eliminated as errors of measurement.