gebhart/patrepeval huggingface dataset:
Inhibitory effect of urate on oxidative damage induced by adriamycin-Fe3+ in the presence of H2O2. (1993)

Urate strongly inhibited DNA damage induced by adriamycin (AD)-Fe3+ in the presence of H2O2. Deoxyribose (DOR) was degraded during the interaction of Ad-Fe3+ with H2O2, and urate strongly inhibited the DOR degradation. However, hydroxyl radical (HO.) scavengers did not always prevent the DOR degradation. ESR signal of 5,5-dimethyl-1-pyroline N-oxide-hydroxyl radical adduct was detected during the interaction of Ad-Fe3+ with H2O2. Mannitol and DNA strongly diminished the ESR signal but urate only poorly did. These results suggested that inhibitory effect of urate on the H2O2-dependent AD-Fe(3+)-induced DNA damage was not always due to trap only HO.. Lipid peroxidation of erythrocyte membrane was induced by AD-Fe3+ alone and H2O2 slightly inhibited the peroxidation reaction. Urate could not inhibit the Ad-Fe(3+)-induced lipid peroxidation. These results indicate that oxygen radical species which causes the lipid peroxidation does not involve in the H2O2-dependent Ad-Fe(3+)-induced DNA damage.
Structural Studies of the Polymorphs of Carbamazepine, Its Dihydrate, and Two Solvates (2005)

High-field cross-polarisation magic-angle spinning 13C NMR spectra are presented for the four known polymorphs of anhydrous carbamazepine, for a dihydrate, and for two solvates. These are all distinctive, despite relatively low spectral dispersion, and give immediate information about the crystallographic asymmetric unit. The results for the trigonal and the two monoclinic forms are consistent with the published crystal structures. That of the triclinic form was found to contain four molecules in the crystallographic asymmetric unit, which has recently been confirmed by an X-ray diffraction study. NMR shows that the dihydrate has one molecule in the asymmetric unit, and the full crystal structure derived from single-crystal X-ray diffraction work is reported herein. It is found to be ordered and monoclinic, in contrast to the reported disordered orthorhombic structure. The discrepancy is attributed to the common occurrence of multiple micro-twinning. Shielding computations using a method which takes explicit account of the repetition inherent in a crystal lattice are reported for the P-monoclinic form and are compared to the experimental chemical shifts. The NMR data of all the forms are discussed in relation to variations in the molecular geometry of the hydrogen-bonded dimers (except in the case of two solvates). Chemical shift variations are explored as a function of the amide torsion using the Gaussian computer program.
Estimation of the parameters of the logistic distribution (1966)

Journal Article Estimation of the parameters of the logistic distribution Get access SHANTI S. GUPTA, SHANTI S. GUPTA Purdue University Search for other works by this author on: Oxford Academic Google Scholar MRUDULLA GNANADESIKAN MRUDULLA GNANADESIKAN Purdue University Search for other works by this author on: Oxford Academic Google Scholar Biometrika, Volume 53, Issue 3-4, December 1966, Pages 565–570, https://doi.org/10.1093/biomet/53.3-4.565 Published: 01 December 1966
Improving Organic Thin‐Film Transistor Performance through Solvent‐Vapor Annealing of Solution‐Processable Triethylsilylethynyl Anthradithiophene (2006)

The current–voltage characteristics of triethylsilylethynyl anthradithiophene (TES ADT) thin-film transistors can be improved dramatically by a simple and straightforward solvent-vapor annealing process after device fabrication. Exposing the transistors to dichloroethane vapor for 2 min induces structural rearrangement and crystallization of TES ADT (see figure and cover). This procedure results in drastic increases in on currents; the saturation mobility increases by two orders of magnitude and the current–voltage hysteresis is largely eliminated.
The predictive value of catecholamines in assessing outcome in traumatic brain injury (1987)

Because of the central role of the sympathetic nervous system in mediating the stress response, plasma norepinephrine (NE), epinephrine (E), and dopamine (DA) levels were measured in 61 traumatically brain-injured patients to determine whether catecholamine (CA) levels obtained within 48 hours after injury provide reliable prognostic markers of outcome. Patient outcome was determined at 1 week using the Glasgow Coma Scale (GCS) and at the time of discharge using the Glasgow Outcome Scale (GOS). Levels of NE, E, and DA correlated highly with the admission GCS score (NE: r = 0.58, p less than 0.0001; E: r = 0.46, p less than 0.0025; DA: r = 0.27, p less than 0.04). Moreover, in the 21 patients with GCS scores of 3 or 4 on admission, NE levels predicted outcome at 1 week. All six patients with NE levels less than 900 pg/ml (normal level less than 447 pg/ml) improved to GCS scores of greater than 11, while 12 of 15 with NE values greater than 900 pg/ml remained with GCS scores of 3 to 6 or died. Levels of E and DA were not as useful. Catecholamine levels also increased significantly as the GOS score worsened. Levels of NE and E were significantly higher in patients who died or remained persistently vegetative than in those with better outcomes. In the 54 patients who survived beyond 1 week, significant correlations were present between the length of hospitalization and NE (r = 0.71, p less than 0.0001) and E (r = 0.61, p less than 0.0001) levels. Concentrations of NE (r = 0.61, p less than 0.0004) and E (r = 0.48, p less than 0.01) were also highly correlated with the duration of ventilatory assistance. Analysis of the interactions of CA levels and GCS scores, duration of ventilatory assistance, and length of hospitalization revealed that the CA's either enhanced the reliability of the GCS score or were independent predictors of outcome. Thus, these findings indicate that alterations in circulating CA levels reflect the severity of the neurological insult and provide support for the use of CA measurements as a physiological marker of patient outcome in both the acute and chronic phases of traumatic brain injury.
Viscoelastic properties of epoxy resins. II. Antiplasticization in highly crosslinked epoxy system (1973)

Abstract The effect of the addition of certain low molecular weight compounds to highly crosslinked epoxy resins was investigated. The behavior which is known as antiplasticization, such as increases in modulus and yield strength and the elimination of β‐transition, was observed in the highly crosslinked system as well as in the reported cases of thermoplastics—poly(vinyl chloride), bisphenol A polycarbonate, and polysulfone. Chlorinated biphenyl was found to be one of the most effective antiplasticizers examined in the present paper. However, the remarkable reduction in compressive strain at break and impact strength was not recognized for the highly antiplasticized samples. These phenomena have been interpreted on the basis of free volume concept.
Low molecular weight heparin suppresses receptor for advanced glycation end products‐mediated expression of malignant phenotype in human fibrosarcoma cells (2013)

The receptor for advanced glycation end products ( RAGE ) is a pattern‐recognition receptor and its engagement by ligands such as high mobility group box 1 ( HMGB 1) is implicated in tumor growth and metastasis. Low molecular weight heparin ( LMWH ) has an antagonistic effect on the RAGE axis and is also reported to exert an antitumor effect beyond the known activity of anticoagulation. However, the link between the anti‐ RAGE and antitumor activities of LMWH has not yet to be fully elucidated. In this study, we investigated whether LMWH could inhibit tumor cell proliferation, invasion, and metastasis by blocking the RAGE axis using in vitro and in vivo assay systems. Stably transformed HT 1080 human fibrosarcoma cell lines were obtained, including human full‐length RAGE ‐overexpressing ( HT 1080 RAGE ), RAGE dominant‐negative, intracellular tail‐deleted RAGE ‐overexpressing ( HT 1080 dnRAGE ), and mock‐transfected control ( HT 1080 mock ) cells. Confocal microscopy showed the expression of HMGB 1 and RAGE in HT 1080 cells. The LMWH significantly inhibited HMGB 1‐induced NF κB activation through RAGE using an NF κB‐dependent luciferase reporter assay and the HT 1080 cell lines. Overexpression of RAGE significantly accelerated, but dn RAGE expression attenuated HT 1080 cell proliferation and invasion in vitro , along with similar effects on local tumor mass growth and lung metastasis in vivo . Treatment with LMWH significantly inhibited the migration, invasion, tumor formation, and lung metastasis of HT 1080 RAGE cells, but not of HT 1080 mock or HT 1080 dnRAGE cells. In conclusion, this study revealed that RAGE exacerbated the malignant phenotype of human fibrosarcoma cells, and that this exacerbation could be ameliorated by LMWH . It is suggested that LMWH has therapeutic potential in patients with certain types of malignant tumors.
System Selection and Sleep Mode for Energy Saving in Cooperative 2G/3G Networks (2009)

In this paper, we focus on developing energy-efficient radio resource management (RRM) algorithms for heterogeneous networks. Our aim is to optimize energy consumption at the network scale, while preserving the quality of service (QoS) perceived by users. We develop a system selection algorithm that finds the optimal traffic allocation for the different systems that minimizes power consumption while insuring the target QoS. We apply our algorithm to a cooperative 2G/3G network and show that only a little gain can be obtained, as base stations still have a large energy consumption even if they have no traffic. We then propose a network scale "sleep mode" where an entire system (2G or 3G) can be desactivated for some traffic scenarios. We show that this mode, together with the energy-aware system selection, achieves large energy reductions.
Congestion Control Protocols in Wireless Sensor Networks: A Survey (2014)

The performance of wireless sensor networks (WSN) is affected by the lossy communication medium, application diversity, dense deployment, limited processing power and storage capacity, frequent topology change. All these limitations provide significant and unique design challenges to data transport control in wireless sensor networks. An effective transport protocol should consider reliable message delivery, energy-efficiency, quality of service and congestion control. The latter is vital for achieving a high throughput and a long network lifetime. Despite the huge number of protocols proposed in the literature, congestion control in WSN remains challenging. A review and taxonomy of the state-of-the-art protocols from the literature up to 2013 is provided in this paper. First, depending on the control policy, the protocols are divided into resource control vs. traffic control. Traffic control protocols are either reactive or preventive (avoiding). Reactive solutions are classified following the reaction scale, while preventive solutions are split up into buffer limitation vs. interference control. Resource control protocols are classified according to the type of resource to be tuned.
Simple Two-Color Base-Calling Schemes for DNA Sequencing Based on Standard Four-Label Sanger Chemistry (1995)

Two base-calling schemes for DNA sequencing are evaluated. Both are based on data collected from two broad-band emission channels derived from either one- or two-excitation channels. Standard four-dye Sanger reaction products are used in conjunction with capillary electrophoretic separation in a polymer matrix. Data acquisition is compatible with high light-throughput imaging and minimal data storage. In one scheme, commercial chromatographic software provides peak recognition and peak heights. The peak-height ratios from the two channels provide base-calling accuracies of 99.3% and 97.1% through 330 bp and 350 bp, respectively. In another scheme, ratiograms are derived from the two channels. The resulting step-like functions permit the calling of bases even when successive peaks are not resolved. The base-calling accuracy is 99% through 340 bp. Because of simplicity in implementation, either scheme should be readily applicable to high-speed, high-throughput DNA sequencing in capillary arrays.
Computer‐aided detection of lung nodules via 3D fast radial transform, scale space representation, and Zernike MIP classification (2011)

The system shows a novel approach to the problem of lung nodule detection in CT scans: It relies on filtering techniques, image transforms, and descriptors rather than region growing and nodule segmentation, and the results are comparable to those of other recent systems in literature and show little dependency on the different types of nodules, which is a good sign of robustness.
The Choline Binding Site of Phospholipase C (<i>Bacillus cereus</i>):  Insights into Substrate Specificity (2000)

The phosphatidylcholine-preferring phospholipase C from Bacillus cereus (PLC(Bc)) is a 28.5 kDa enzyme with three zinc ions in its active site. The roles that a number of amino acid residues play as zinc ligands and in binding and catalysis have been elucidated. Recent mechanistic studies indicate that the rate of the reaction is limited by a proton-transfer step during chemical hydrolysis and not substrate binding or product release. An X-ray structure of PLC(Bc) complexed with a phosphonate inhibitor related to phosphatidylcholine revealed that the three amino acid residues Glu4, Tyr56, and Phe66 comprise the choline binding pocket. However, because the contributions that these three residues make to substrate recognition and specificity were unknown, a series of site-specific mutants for Glu4, Tyr56, and Phe66 were constructed by PCR mutagenesis. On the basis of a comparison of their respective CD spectra and melting temperatures, it appears that the mutants adopt folded structures in solution that are virtually identical to that of wild-type PLC(Bc). The kinetic parameters k(cat) and K(m) for the hydrolysis of the three soluble substrates 1, 2-dihexanoyl-sn-glycero-3-phosphocholine (C6PC), 1, 2-dihexanoyl-sn-glycero-3-phosphoethanolamine (C6PE), and 1, 2-dihexanoyl-sn-glycero-3-phospho-L-serine (C6PS) at concentrations below their corresponding critical micelle concentration (cmc) values were determined for each mutant. Replacement of Phe66 with a nonaromatic residue dramatically decreased k(cat) (approximately 200-fold) and reduced PLC(Bc) activity toward C6PC, C6PE, and C6PS, whereas changes to Glu4 and Tyr56 typically led to much more modest losses in catalytic efficiencies. Mutations of Glu4 had relatively little effect upon k(cat) and K(m) for C6PS, but they significantly influenced K(m) for C6PC and C6PE. Replacing Tyr56 with nonaromatic residues also affects catalytic efficiency, albeit to a much lesser degree than the corresponding changes at position 66. However, the presence of an aromatic residue at position 56 seems to confer some substrate selectivity for C6PC and C6PE, which bear a positive charge on the headgroup, relative to C6PS, which has no net charge on the headgroup; this increase in specificity arises largely from a reduced k(cat) for C6PS.
Software process control for secure program execution (2010)

The lack of basic principles of engineering design and discipline has led to some very serious problems in the computer security arena. At the heart of modern power systems are Supervisory Control and Data Acquisition (SCADA) software systems that provide real time control and data management [2]. It is interesting to note that every aspect of a hardware system that is under control of the SCADA architecture is fully instrumented and the operation of the monitored system is totally under management of the control system. However, the software that controls the entire power grid is essentially open loop and uncontrolled. It would be unthinkable to build a complex hardware system without embedding monitors for process control throughout the whole architecture. Ironically, the backbone of modern control systems, SCADA for example, is almost entirely dependent on a software system that is running out of control
Comparing Oblique Lumbar Interbody Fusion with Lateral Screw Fixation and Transforaminal Full‐Endoscopic Lumbar Discectomy (OLIF‐TELD) and Posterior Lumbar Interbody Fusion (PLIF) for the Treatment of Adjacent Segment Disease (2020)

OLIF with lateral screw fixation combined with TELD may be an alternative surgical method for the treatment of adjacent lumbar disc herniation with upward or downward migration after lumbar fusion surgery.
Synthesis of isoflavones. Part IV. Munetone (1966)

S. F. Dyke, W. D. Ollis and M. Sainsbury, J. Chem. Soc. C, 1966, 749 DOI: 10.1039/J39660000749
Synthetic enterotoxin B DNA probes for detection of enterotoxigenic Staphylococcus aureus strains (1988)

DNA-DNA colony hybridization experiments with three different synthetic probes were carried out with 210 strains of Staphylococcus aureus. The synthetic probes encoded the amino acids 15 to 29 (probe 1), 179 to 192 (probe 2), and 207 to 219 (probe 3) of staphylococcal enterotoxin B (SEB). The amino acid sequences of these parts of SEB are identical to those of SEC1. All 21 SEB-producing strains tested reacted with each of the three probes. Of the 69 SEC-producing strains, 21 reacted with probe 1, none reacted with probe 2, and all 69 reacted with probe 3. With other strains no hybridization signals were obtained. The results presented here show that with a single synthetic DNA probe (probe 3) both SEB- and SEC-producing strains are detectable.
A novel human leukocyte differentiation antigen: monoclonal antibody anti-D44 defines a 28 Kd molecule present on immature hematologic cells and a subpopulation of mature T cells. (1984)

Anti-D44 is a cytotoxic IgG2b monoclonal antibody (MAb), which reacts with two polypeptides of 28 and 30 Kd from human peripheral T cells after western blotting. The antigen is present in low density on bone marrow cells from the myeloid lineage, probably including most CFU-GM; the antigen is present on megakaryocytes but is not detectable on erythroid cells as well as pre-B and B cells. Growth of BFU-E appears to be partially inhibited after treatment with anti-D44 + complement, an effect that should be due to bone marrow T cells rather than to BFU-E destruction. With maturation, the antigen is barely detectable on mature polymorphonuclear neutrophils, and is not detectable on platelets and monocytes. In contrast, cells from the thymic cortex carry a high density of this molecule; medullary thymocytes carry a low density. Large thymocytes ("thymoblasts") distinct from epithelial or interdigitating cells also bear a high density of the antigen. In the periphery, a subpopulation of T cells displays a high density of D44 molecules. D44 antigenic density is not linked to cell growth or to T cell activation. Double labeling and cell sorting experiments have shown that 40% of E rosette-forming cells are D44(+)-CD4+, 10% are CD8(+)-D44+ and 10% are CD4(-)+CD8-, CD2+. In an accompanying report, correlation is shown between expression of the D44 defined molecule on T cell subpopulations and the function they exert. Immunoperoxidase studies of skin, brain, and kidney tissues, facilitated by the fact that the antigen is resistant to inclusion in Epon, which permits staining of semi-thin sections, have not revealed any positive nonhematologic cell.
Charge dynamics of a molecular ion immersed in a Rydberg-dressed atomic lattice gas (2019)

Charge dynamics in an ultracold setup involving a laser-dressed atom and an ion is studied here. This transfer of charge is enabled through molecular Rydberg states that are accessed via a laser. The character of the charge exchange crucially depends on the coupling between the electronic dynamics and the motional dynamics of the atoms and ion. The molecular Rydberg states are characterized and a criterion for distinguishing coherent and incoherent regimes is formulated. Furthermore the concept is generalized to the many-body setup as the ion effectively propagates through a chain of atoms. Aspects of the transport, such as its direction, can be controlled by the excitation laser. This leads to new directions in the investigation of hybrid atom-ion systems that can be experimentally explored using optically trapped strontium atoms.
Visualization methods for outdoor see-through vision (2005)

Visualizing occluded objects is a useful applications of Mixed Reality (MR), which we call vision. For this application, it is important to display occluded objects in such a manner that they can be recognized intuitively by the user.Here, we evaluated five visualization methods for see-through vision that help the user to intuitively recognize occluded objects in outdoor scenes: elimination of occluding object, model of occluding object, view, and on-off switching of MR display. As we applied a new handheld MR device for outdoor see-through vision, we conducted subjective experiments to determine the best combination of methods. The experimental results indicated the combination of showing the ground grid, overlaying the wire-frame models of occluding objects, and top-down view to be optimal, while it is not necessary to display occluding objects for outdoor see-through vision with a handheld device, because users can see them with the naked eye.
Safety of allergen‐specific immunotherapy. Relation between dosage regimen, allergen extract, disease and systemic side‐effects during induction treatment (2000)

An 8-week clustered induction regimen using alum depot extract seems an acceptable compromise in relation to a reduction in the time used to reach maintenance dose and the risk of inducing clinically relevant systemic side-effects, and consequently imply a reduction in the costs of the treatment.
The Thermal Decomposition of Tri-n-butylborane (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Thermal Decomposition of Tri-n-butylboraneLouis RosenblumCite this: J. Am. Chem. Soc. 1955, 77, 19, 5016–5017Publication Date (Print):October 1, 1955Publication History Published online1 May 2002Published inissue 1 October 1955https://pubs.acs.org/doi/10.1021/ja01624a023https://doi.org/10.1021/ja01624a023research-articleACS PublicationsRequest reuse permissionsArticle Views72Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts