gebhart/patrepeval huggingface dataset:
The Use of Animal Models to Study Bacterial Translocation During Acute Pancreatitis (2007)

Infection of pancreatic necrosis with intestinal flora is accepted to be a main predictor of outcome during severe acute pancreatitis. Bacterial translocation is the process whereby luminal bacteria migrate to extraintestinal sites. Animal models were proven indispensable in detecting three major aspects of bacterial translocation: small bowel bacterial overgrowth, mucosal barrier failure, and disturbed immune responses. Despite the progress made in the knowledge of bacterial translocation, the exact mechanism, origin and route of bacteria, and the optimal prophylactic and treatment strategies remain unclear. Methodological restrictions of animal models are likely to be the cause of this uncertainty. A literature review of animal models used to study bacterial translocation during acute pancreatitis demonstrates that many experimental techniques per se interfere with intestinal flora, mucosal barrier function, or immune response. Interference with these major aspects of bacterial translocation complicates interpretation of study results. This paper addresses these and other issues of animal models most frequently used to study bacterial translocation during acute pancreatitis.
A Summary of the Forebody High-Angle-of-Attack Aerodynamics Research on the F-18 and the X-29A Aircraft (1992)

High-angle-of-attack aerodynamic studies have been conducted on both the F18 High Alpha Research Vehicle (HARV) and the X-29A aircraft. Data obtained include on- and off-surface flow visualization and static pressure measurements on the forebody. Comparisons of similar results are made between the two aircraft where possible. The forebody shapes of the two aircraft are different and the X-29A forebody flow is affected by the addition of nose strakes and a flight test noseboom. The forebody flow field of the F-18 HARV is fairly symmetric at zero sideslip and has distinct, well-defined vortices. The X-29A forebody vortices are more diffuse and are sometimes asymmetric at zero sideslip. These asymmetries correlate with observed zero-sideslip aircraft yawing moments.
Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells (2003)

Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a major role in acetaldehyde detoxification. The alcohol sensitivity is associated with a genetic deficiency of ALDH2. We have previously reported that this deficiency influences the risk for late-onset Alzheimer's disease. However, the biological effects of the deficiency on neuronal cells are poorly understood. Thus, we obtained ALDH2-deficient cell lines by introducing mouse mutant Aldh2 cDNA into PC12 cells. The mutant ALDH2 repressed mitochondrial ALDH activity in a dominant negative fashion, but not cytosolic activity. The resultant ALDH2-deficient transfectants were highly vulnerable to exogenous 4-hydroxy-2-nonenal, an aldehyde derivative generated by the reaction of superoxide with unsaturated fatty acid. In addition, the ALDH2-deficient transfectants were sensitive to oxidative insult induced by antimycin A, accompanied by an accumulation of proteins modified with 4-hydroxy-2-nonenal. Thus, these findings suggest that mitochondrial ALDH2 functions as a protector against oxidative stress.
Novel Cooperative and Fully-Distributed Congestion Control Mechanism for Content Centric Networking (2017)

The router's buffer accommodates transient packets to guarantee that the network's links do not become idle. However, buffer overflow causes packet loss, which is a signal of congestion. In content centric networking (CCN), the interest packet, which is used for requesting content, may be dropped due to such congestion. Each interest packet is assigned a specific lifetime, and when the lifetime expires without obtaining the requested content, the consumer needs to resend the Interest. However, waiting for the expiration of an Interest's lifetime for retransmission is only appropriate for best effort traffic rather than services that are delay sensitive. In order to provide delay-sensitive applications with better quality of service, we propose a congestion control mechanism for CCN, in which, we prevent congestion before it happens through monitoring buffer size. Upon reaching the buffer threshold, the node notifies its downstream node. On receiving the notification, the downstream node adjusts traffic rate by allocating new incoming Interests to other face(s). However, when the downstream node fails to reduce traffic rate, the same procedure continues until the consumer node reduces sending rate. The simulation results show that the proposed mechanism is capable of significant performance improvements, with higher throughput.
Tag-free garbage collection for strongly typed programming languages (1991)

With the emergence of a number of strongly typed kmguages with very dynamic storage allocation, efficient methods of storage reclamation have become especially important, Even though no type tags are required for type checking programs written in these languages, current implementations douse tags to support run time garbage collection, This often inflicts a high time and space overhead on program execution. Since the early days of LISP (and Algo168 later on), there have been schemes for performing tag-free garbage collection, In this paper, we describe an improvement of existing methods that leads to more effective storage rechunation in the absence of tags. Garbage collection has also traditionally been viewed as being independent of the particular program being executed. This means that results of compile-time analyses which could increase the effectiveness of garbage collection cannot be incorporated easily into the garbage collection process. This paper describes a method for performing garbage collection 1) in the absence of tagged data, and 2) using compile-time information. This method relies on compiler-generated garbage collection routines specific to the program bekg executed and incurs no time overhead during execution other then the cost of the garbage collection process itself. We describe tag-free garbage collection methods for monomorphically typed and polymorphically typed languages, and suggest how they might be extended to support parallel languages.
Group Efforts toward Self Government and Social Responsibility (1956)

Theodore D. Rice, Chandos Reid, Group Efforts toward Self Government and Social Responsibility, The Journal of Educational Sociology, Vol. 30, No. 2, Youth as Citizens: A Study of Adolescent Self-Direction and Social Responsibility (Oct., 1956), pp. 75-93
Optimization-based design of a heat flux concentrator (2017)

To gain control over the diffusive heat flux in a given domain, one needs to engineer a thermal metamaterial with a specific distribution of the generally anisotropic thermal conductivity throughout the domain. Until now, the appropriate conductivity distribution was usually determined using transformation thermodynamics. By this way, only a few particular cases of heat flux control in simple domains having simple boundary conditions were studied. Thermal metamaterials based on optimization algorithm provides superior properties compared to those using the previous methods. As a more general approach, we propose to define the heat control problem as an optimization problem where we minimize the error in guiding the heat flux in a given way, taking as design variables the parameters that define the variable microstructure of the metamaterial. In the present study we numerically demonstrate the ability to manipulate heat flux by designing a device to concentrate the thermal energy to its center without disturbing the temperature profile outside it.
Water-mediated signal multiplication with Y-shaped carbon nanotubes (2009)

Molecular scale signal conversion and multiplication is of particular importance in many physical and biological applications, such as molecular switches, nano-gates, biosensors, and various neural systems. Unfortunately, little is currently known regarding the signal processing at the molecular level, partly due to the significant noises arising from the thermal fluctuations and interferences between branch signals. Here, we use molecular dynamics simulations to show that a signal at the single-electron level can be converted and multiplied into 2 or more signals by water chains confined in a narrow Y-shaped nanochannel. This remarkable transduction capability of molecular signal by Y-shaped nanochannel is found to be attributable to the surprisingly strong dipole-induced ordering of such water chains, such that the concerted water orientations in the 2 branches of the Y-shaped nanotubes can be modulated by the water orientation in the main channel. The response to the switching of the charge signal is very rapid, from a few nanoseconds to a few hundred nanoseconds. Furthermore, simulations with various water models, including TIP3P, TIP4P, and SPC/E, show that the transduction capability of the Y-shaped carbon nanotubes is very robust at room temperature, with the interference between branch signals negligible.
Impact 9 of Low Concentration Factor Microfiltration on Milk Component Recovery and Cheddar Cheese Yield (2002)

The effect of microfiltration (MF) on the composition of Cheddar cheese, fat, crude protein (CP), calcium, total solids recovery, and Cheddar cheese yield efficiency (i.e., composition adjusted yield divided by theoretical yield) was determined. Raw skim milk was microfiltered twofold using a 0.1-microm ceramic membrane at 50 degrees C. Four vats of cheese were made in one day using milk at lx, 1.26x, 1.51x, and 1.82x concentration factor (CF). An appropriate amount of cream was added to achieve a constant casein (CN)-to-fat ratio across treatments. Cheese manufacture was repeated on four different days using a randomized complete block design. The composition of the cheese was affected by MF. Moisture content of the cheese decreased with increasing MF CF. Standardization of milk to a constant CN-to-fat ratio did not eliminate the effect of MF on cheese moisture content. Fat recovery in cheese was not changed by MF. Separation of cream prior to MF, followed by the recombination of skim or MF retentate with cream resulted in lower fat recovery in cheese for control and all treatments and higher fat loss in whey when compared to previous yield experiments, when control Cheddar cheese was made from unseparated milk. Crude protein, calcium, and total solids recovery in cheese increased with increasing MF CF, due to partial removal of these components prior to cheese making. Calcium and calcium as a percentage of protein increased in the cheese, suggesting an increase in calcium retention in the cheese with increasing CF. While the actual and composition adjusted cheese yields increased with increasing MF CF, as expected, there was no effect of MF CF on cheese yield efficiency.
Combined DWT-DCT Digital Image Watermarking (2007)

The proliferation of digitized media due to the rapid growth of networked multimedia systems, has created an urgent need for copyright enforcement technologies that can protect copyright ownership of multimedia objects. Digital image watermarking is one such technology that has been developed to protect digital images from illegal manipulations. In particular, digital image watermarking algorithms which are based on the discrete wavelet transform have been widely recognized to be more prevalent than others. This is due to the wavelets' excellent spatial localization, frequency spread, and multi-resolution characteristics, which are similar to the theoretical models of the human visual system. In this paper, we describe an imperceptible and a robust combined DWT-DCT digital image watermarking algorithm. The algorithm watermarks a given digital image using a combination of the Discrete Wavelet Transform (DWT) and the Discrete Cosine Transform (DCT). Performance evaluation results show that combining the two transforms improved the performance of the watermarking algorithms that are based solely on the DWT transform.
Inhibitors of the Hill reaction (1961)

Many commercially important herbicides seem to kill plants by inhibiting photosynthesis. Wessels and van der Veen have shown that leaves or parts of leaves treated with phenylureas irreversibly lose
The Photo-Oxidation of Polypropylene Monofilaments (1976)

The photo-oxidation of commercial, isotactic polypropylene monofilament, initiated by xenon-arc irradiation in air, leads to the initial accumulation in the fiber surface of both carbonyl species and hydroperoxide groups. These chemical changes are accompanied by a severe drop in the elongation at break. Extended irradiation leads to a substantial accumulation of these oxidation products throughout the fiber and to a loss of tensile strength. Oxidation products were identified and estimated from transmission and internal reflection in spectroscopy [∼C(O)∼ and —OH] and by chemical analysis (—OOH). Marked increases in fiber wettability were also found to accompany photo-oxidation. Distinct differences in product ratios from photo-oxidized polypropylene film and fiber samples were observed. These differences are consistent with the morphological control of the efficiency of initiation after hydroperoxide photocleavage, but are more likely to result from some radical scavenging by the unextractable phenolic additive in the commercial fiber.
Test-suite reduction and prioritization for modified condition/decision coverage (2002)

Software testing is particularly expensive for developers of high-assurance software, such as software that is produced for commercial airborne systems. One reason for this expense is the Federal Aviation Administration's requirement that test suites be modified condition/decision coverage (MC/DC) adequate. Despite its cost, there is evidence that MC/DC is an effective verification technique, and can help to uncover safety faults. As the software is modified and new test cases are added to the test suite, the test suite grows, and the cost of regression testing increases. To address the test-suite size problem, researchers have investigated the use of test-suite reduction algorithms, which identify a reduced test suite that provides the same coverage of the software, according to some criterion, as the original test suite, and test-suite prioritization algorithms, which identify an ordering of the test cases in the test suite according to some criteria or goals. Existing test-suite reduction and prioritization techniques, however, may not be effective in reducing or prioritizing MC/DC-adequate test suites because they do not consider the complexity of the criterion. The paper presents new algorithms for test-suite reduction and prioritization that can be tailored effectively for use with MC/DC. The paper also presents the results of a case study of the test-suite reduction algorithm.
Effects of MCI-727, a New Antiulcer Agent, on Various Gastric and Duodenal Lesions in Experimental Animals (1991)

Effects of a new antiulcer drug. MCI-727, on gastric and duodenal lesions, gastric secretion and gastric motility were studied in comparison with cimetidine and teprenone. MCI-727 dose-dependently (3-100mg/kg, p.o. or i.d.) inhibited the development of acute gastric or duodenal lesions such as pyrolus ligation-, waterimmersion stress-, ¡ndomethacin-, HCl-, HCl-cthanol-induced gastric lesions and cysteamine-induced duodenal lesions in rats and histamine-induced duodenal lesions in guinea pigs. These antiulcer effects exceeded those of cimetidine or teprenone. Repeated administration of MCI-727 (0.3-3 mg/kg/day, p.o., for 10 days) significantly promoted the spontaneous healing of acetic acid-induced chronic gastric ulcers. Concerning gastric acid secretion, MCI-727 selectively inhibited tetragastrin-stimulated acid secretion without effecting basal acid secretion and acid secretion by other stimuli. Cimetidine and teprenone inhibited acid secretion in several cases. MCI-727 and teprenone had inhibitory effects on gastric motility, although cimetidine had no effect. These results suggest that MCI-727 has a wide spectrum of antiulcer activity, and its mode of antiulcer action is different from that of cimetidine or teprenone.
Emerging treatments for premature ejaculation: focus on dapoxetine (2008)

Premature ejaculation (PE) is a common problem in men worldwide. It has a significant impact on affected men and their partners in terms of self-esteem, dissatisfaction with their sexual relationships, personal distress, and interpersonal difficulty. Psychological therapies may achieve short-term improvements, but there are limited data on the long-term success of these methods. Oral therapy with long-acting selective serotonin reuptake inhibitors (SSRIs) improves intravaginal ejaculatory latency time (IELT), but these agents are designed to be administered daily and may be associated with unwanted sexual side effects and withdrawal symptoms upon abrupt discontinuation. Dapoxetine is a short-acting SSRI that can be taken as needed (prn) by men with PE. It has been studied in five separate multicenter, randomized, double-blind, placebo-controlled trials involving more than 6000 men with PE. In four studies that evaluated IELT as an endpoint (N = 4843), dapoxetine 30 and 60 mg prn achieved statistically significant increases in IELT versus placebo. Dapoxetine also showed statistically significant improvements in perceived control over ejaculation, PE-related personal distress, and other patient-reported outcomes in all five trials. Dapoxetine treatment is generally well-tolerated, with low incidences of discontinuation syndrome, sexual dysfunction, and treatment-emergent mood symptoms. The most common adverse events with dapoxetine included nausea, diarrhea, headache, dizziness, and somnolence.
Identification of plant-inducible genes in Erwinia chrysanthemi 3937 (1990)

We present a method for identifying plant-inducible genes of Erwinia chrysanthemi 3937. Mutagenesis was done with the Mu dIIPR3 transposon, which carries a promoterless neomycin phosphotransferase gene (nptI), so upon insertion, the truncated gene can fuse to E. chrysanthemi promoters. Mutants containing insertions in plant-inducible genes were selected for their sensitivity to kanamycin on minimal plates and for their acquired resistance to this antibiotic when an S. ionantha plant extract was added to kanamycin minimal plates. The selection allowed the identification of E. chrysanthemi promoters inducible by host factors present in the S. ionantha plant extract. Using this method, we isolated 30 mutants and characterized 10 of them. Two mutants were defective in cation uptake, one was defective in the galacturonate degradation pathway, and another was altered in the production of the acidic pectate lyase. The functions of the other mutated genes are still unknown, but we show that most of them are involved in pathogenicity.
Enhancing the performance of tiled loop execution onto clusters using memory mapped network interfaces and pipelined schedules (2002)

This paper describes the performance benefits attained using enhanced network interfaces to achieve low latency communication. Our experimental testbed concerns the parallel execution of tiled nested loops onto a Linux PC cluster with PCI-SCI NICs (Dolphin D330). Tiles are nec- essarily exchanging data and should also have large com- putational grain, so that their parallel execution becomes beneficial. We schedule
Surf Zone Imaging with a Moored Video System (2001)

Measuring devices that are fixed to definite points are employed in the usual surf zone observation which provide accurate time records. The deployment of the instruments, however, is limited in most field experiments, which restricts the spatial understanding of the surf zone dynamics. In this context, a moored video system is developed to obtain spatial images of the surf zone. Field experiments were conducted at HORS, a research pier located in Hazaki, Japan. Results of the video record processing demonstrate the potential of the system. There are some foregoing studies existent in coastal studies using video techniques which are mainly concentrating on inferring the sea bottom profiles by image analyses. This study is a new approach, which tries to reveal spatial and temporal variation of the surf zone hydrodynamics.
PLGA nanocomposites loaded with verteporfin and gold nanoparticles for enhanced photodynamic therapy of cancer cells (2016)

Enhanced <sup>1</sup>O<sub>2</sub> generation from PLGA loaded with verteporfin and gold nanoparticles under light illumination has the potential to improve cancer cell-killing effect.
Analysis of Mutations in the Pore-Forming Region Essential for Insecticidal Activity of a <i>Bacillus thuringiensis</i> δ-Endotoxin (1999)

The Bacillus thuringiensis insecticidal delta-endotoxins have a three-domain structure, with the seven amphipathic helices which comprise domain I being essential for toxicity. To better define the function of these helices in membrane insertion and toxicity, either site-directed or random mutagenesis of two regions was performed. Thirty-nucleotide segments in the B. thuringiensis cry1Ac1 gene, encoding parts of helix alpha4 and the loop connecting helices alpha4 and alpha5, were randomly mutagenized. This hydrophobic region of the toxin probably inserts into the membrane as a hairpin. Site-directed mutations were also created in specific surface residues of helix alpha3 in order to increase its hydrophobicity. Among 12 random mutations in helix alpha4, 5 resulted in the total loss of toxicity for Manduca sexta and Heliothis virescens, another caused a significant increase in toxicity, and one resulted in decreased toxicity. None of the nontoxic mutants was altered in toxin stability, binding of toxin to a membrane protein, or the ability of the toxin to aggregate in the membrane. Mutations in the loop connecting helices alpha4 and alpha5 did not affect toxicity, nor did mutations in alpha3, which should have enhanced the hydrophobic properties of this helix. In contrast to mutations in helix alpha5, those in helix alpha4 which inactivated the toxin did not affect its capacity to oligomerize in the membrane. Despite the formation of oligomers, there was no ion flow as measured by light scattering. Helix alpha5 is important for oligomerization and perhaps has other functions, whereas helix alpha4 must have a more direct role in establishing the properties of the channel.