gebhart/patrepeval huggingface dataset:
Integration and electrical isolation in CMOS mixed-signal wireless chips (2001)

The technological trends underlying the application of CMOS technology in wireless applications are leading to the integration of the RF analog functions and the digital baseband processing into a single chip. Two key technical requirements for this integration are the capability to fabricate high Q passive components and the need to maintain electrical isolation between analog and digital components in the resulting mixed-signal chip. Some basic arguments that illustrate the technological conflict between these two important demands are presented, focusing on their implications for the structure of the IC substrate. This structure and the characteristics of the device package play important robs in determining the levels of coupled ground noise that will be present in the mixed-signal IC. A simple, high-level model for coupled ground noise is presented and used to illustrate the impact of design alternatives for the package and for the IC substrate.
Live Cell Imaging of <em>Bacillus subtilis</em> and <em>Streptococcus pneumoniae</em> using Automated Time-lapse Microscopy (2011)

During the last few years scientists became increasingly aware that average data obtained from microbial population based experiments are not representative of the behavior, status or phenotype of single cells. Due to this new insight the number of single cell studies rises continuously (for recent reviews see (1,2,3)). However, many of the single cell techniques applied do not allow monitoring the development and behavior of one specific single cell in time (e.g. flow cytometry or standard microscopy). Here, we provide a detailed description of a microscopy method used in several recent studies (4, 5, 6, 7), which allows following and recording (fluorescence of) individual bacterial cells of Bacillus subtilis and Streptococcus pneumoniae through growth and division for many generations. The resulting movies can be used to construct phylogenetic lineage trees by tracing back the history of a single cell within a population that originated from one common ancestor. This time-lapse fluorescence microscopy method cannot only be used to investigate growth, division and differentiation of individual cells, but also to analyze the effect of cell history and ancestry on specific cellular behavior. Furthermore, time-lapse microscopy is ideally suited to examine gene expression dynamics and protein localization during the bacterial cell cycle. The method explains how to prepare the bacterial cells and construct the microscope slide to enable the outgrowth of single cells into a microcolony. In short, single cells are spotted on a semi-solid surface consisting of growth medium supplemented with agarose on which they grow and divide under a fluorescence microscope within a temperature controlled environmental chamber. Images are captured at specific intervals and are later analyzed using the open source software ImageJ.
Smoking, spasticity and pressure sores in spinal cord injured patients. (1983)

The most important factors for the formation of pressure sores are sufficient pressure for an adequate period of time. Many investigators have shown that psycho-social factors are also associated with pressure sores. We investigated other factors that may relate to higher incidence and more extensive pressure sores. Seventeen paraplegics and 21 quadriplegics were clinically examined regarding the degree of spasticity and the size of their pressure sores were measured. They were interviewed for cigarette smoking habit, the presence of help in skin care and their employment or educational activities. Body weight was obtained and the types of wheelchair cushion used were inspected. The result shows that patients with more pack-years of smoking habit had higher incidence and more extensive pressure sores. Other variables such as level of spinal cord injury, completeness of neurological lesion, the availability of help in skin care, the presence of employment or educational activities, spasticity, and body weight were not associated with pressure sores. The types of wheelchair cushion used by our patients did not correlate to the incidence of pressure sores. In addition, cigarette smoking did not decrease spasticity in our patients.
Comparison of the Activity of a Human Simulated, High-Dose, Prolonged Infusion of Meropenem against <i>Klebsiella pneumoniae</i> Producing the KPC Carbapenemase versus That against <i>Pseudomonas aeruginosa</i> in an <i>In Vitro</i> Pharmacodynamic Model (2009)

We have previously demonstrated that a high-dose, prolonged-infusion meropenem regimen (2 g every 8 h [q8h]; 3-hour infusion) can achieve 40% free drug concentration above the MIC against Pseudomonas aeruginosa with MICs of <or=16 microg/ml. The objective of this experiment was to compare the efficacy of this high-dose, prolonged-infusion regimen against carbapenemase-producing Klebsiella pneumoniae isolates with the efficacy against P. aeruginosa isolates having similar meropenem MICs. An in vitro pharmacodynamic model was used to simulate human serum concentrations. Eleven genotypically confirmed K. pneumoniae carbapenemase (KPC)-producing isolates and six clinical P. aeruginosa isolates were tested for 24 h, and time-kill curves were constructed. High-performance liquid chromatography (HPLC) was used to verify meropenem concentrations in each experiment. Meropenem achieved a rapid >or=3 log CFU reduction against all KPC isolates within 6 h, followed by regrowth in all but two isolates. The targeted %fT>MIC (percent time that free drug concentrations remain above the MIC) exposure was achieved against both of these KPC isolates (100% fT>MIC versus MIC=2 microg/ml, 75% fT>MIC versus MIC=8 microg/ml). Against KPC isolates with MICs of 8 and 16 microg/ml that did regrow, actual meropenem exposures were significantly lower than targeted due to rapid in vitro hydrolysis, whereby targeted %fT>MIC was reduced with each subsequent dosing. In contrast, a >or=3 log CFU reduction was maintained over 24 h for all Pseudomonas isolates with meropenem MICs of 8 and 16 microg/ml. Although KPC and P. aeruginosa isolates may share similar meropenem MICs, the differing resistance mechanisms produce discordant responses to a high-dose, prolonged infusion of meropenem. Thus, predicting the efficacy of an antimicrobial regimen based on MIC may not be a valid assumption for KPC-producing organisms.
Inverse-photoemission spectroscopy at the metal-electrolyte interface (1986)

The principle of the inverse photoelectric effect has been applied to the study of the metal-electrolyte interface. It is shown that charge-transfer-reaction inverse-photoemission spectroscopy is capable of investigating both empty and occupied electronic states in the inter- facial region. Results for Au(111) electrodes in solutions of tetra- propylammonium tetrafluoroborate in acetonitrile, containing either electron-donor or electron-acceptor molecules, are presented. The spectra obtained by this new technique, for both electron and hole injection into the metal, are shown to contain a wealth of detailed information about, for example, interfacial electronic states and molecular reorganization processes.
Optimising sliding transformers for contactless power transmission systems (2002)

Contactless power delivery systems for mobile loads use transformers comprised of a core with a secondary winding sliding along an extended primary winding. The transformer, the most limiting component in the system, is analyzed by representing it as a special power transmission line. Two performance parameters, namely the transmission line efficiency and system quality factor, are introduced. It is shown that fundamental restrictions may limit the attainable performance of the system. The inductance of the primary winding is identified as a parameter which can be optimized to improve the system performance. Experimental results for a short and a long stroke transformer are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Optimal Estimator Model for Human Spatial Orientation<sup>a</sup> (1988)

A model is presented to predict human dynamic spatial orientation in response to multisensory stimuli. Motion stimuli are first processed by dynamic models of the visual, vestibular, tactile, and proprioceptive sensors. Central nervous system function is modeled as a steady state Kalman filter that optimally blends information from the various sensors to form an estimate of spatial orientation. Where necessary, nonlinear elements preprocess inputs to the linear central estimator in order to reflect more accurately some nonlinear human response characteristics. Computer implementation of the model has shown agreement with several important qualitative characteristics of human spatial orientation.
Extraction of recursion level parallelism for embedded multicore systems (2017)

Recursive programs that typically implement divide-and-conquer algorithms are well-suited for multicore systems, as they offer a high degree of parallelization potential. So far, existing parallelizing compilers have mainly focused on extracting other parallel patterns, such as data or pipeline level parallelism. In this paper, we propose a toolflow for the extraction of recursion level parallelism for embedded multicore systems. To achieve this, the toolflow verifies not only the mutual independence of recursive call-sites, but also selects an appropriate task granularity to ensure a good trade-off between load balancing and parallelization overhead. Profitable parallelization opportunities are implemented by using compiler directives from the OpenMP tasking model. Results show the effectiveness of our toolflow, as it is able to speedup sequential recursive programs between 2.5× and 3.8× on a quad-core platform.
The clinical assessment of the patient with early dementia (2005)

ementia is a clinical state characterised by a loss of function in at least two cognitive domains. When making a diagnosis of dementia, features to look for include memory impairment and at least one of the following: aphasia, apraxia, agnosia and/or disturbances in executive functioning. To be significant the impairments should be severe enough to cause problems with social and occupational functioning and the decline must have occurred from a previously higher level. It is important to exclude delirium when considering such a diagnosis.
Inter-Cell Interference Coordination (ICIC) Technology (2012)

Long Term Evolution (LTE) is a promising standard for next-generation cellular systems targeted to have a peak downlink bit rate of 150 Mb/s. However, as adjacent cells use the same frequency, interference between adjacent cells may degrade the bit rate at cell edges, preventing sufficient throughput from being obtained. Inter-cell interference coordination (ICIC) is a promising technology for alleviating this degradation and improving the bit rate at cell edges. In the LTE standard, an interface between adjacent base stations is specified for exchanging ICIC information. However, no methods or control algorithms have been specified for using this interface, leaving it to base station vendors to develop them on their own. This paper outlines ICIC technology in the LTE system, describes the original ICIC algorithm we have developed, and discusses its evaluation.
Embedded software-based self-test for programmable core-based designs (2002)

The programmable cores on SoCs can perform on-chip test generation, measurement, response analysis, and even diagnosis. This software-based approach to self-testing enables at-speed testing and incurs low DFT overhead. We give an overview of the existing embedded software-based self-testing and self-diagnosis methods for core-based SoC designs, and we discuss the challenges to further developing this new testing paradigm.
Relaxation Analysis of Bolt Load in Single Bolted Joints Fastening Thermosetting Polymer (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Substituted Sulfaquinoxalines. III. Extension of the Glyoxalate Synthesis of 2-Aminoquinoxaline (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituted Sulfaquinoxalines. III. Extension of the Glyoxalate Synthesis of 2-AminoquinoxalineF. J. Wolf, Karl. Pfister, R. H. Beutel, R. M. Wilson, C. A. Robinson, and J. R. StevensCite this: J. Am. Chem. Soc. 1949, 71, 1, 6–10Publication Date (Print):January 1, 1949Publication History Published online1 May 2002Published inissue 1 January 1949https://pubs.acs.org/doi/10.1021/ja01169a001https://doi.org/10.1021/ja01169a001research-articleACS PublicationsRequest reuse permissionsArticle Views327Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gust load conditions for fatigue tests vased on a continuous gust concept (1997)

Newly designed aircraft structures must be subjected to full scale fatigue/damage tolerance testing. The present paper describes an automated procedure for the generation of fatigue test load sequences, with specific reference to gust loads. The procedure uses a continuous gust concept. A statistical gust model, based on gust data recently published by FAA, is proposed. Specific attention is paid to the determination of the incremental load distributions due to gust on PSD basis.
Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains (2013)

In summary, our results revealed the neuroprotective benefits of NIr treatment after parkinsonian insult at both cellular and behavioural levels and suggest that Balb/c strain, due to greater penetration of NIr through skin and fur, provides a clearer model of protection than the C57BL/6 strain.
Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies (2009)

Gold compounds are a class of metallodrugs with great potential for cancer treatment. During the last two decades, a large variety of gold(I) and gold(III) compounds are reported to possess relevant antiproliferative properties in vitro against selected human tumor cell lines, qualifying themselves as excellent candidates for further pharmacological evaluation. The unique chemical properties of the gold center confer very interesting and innovative pharmacological profiles to gold-based metallodrugs. The primary goal of this review is to define the state of the art of preclinical studies on anticancer gold compounds, carried out either in vitro or in vivo. The available investigations of anticancer gold compounds are analyzed in detail, and particular attention is devoted to underlying molecular mechanisms. Notably, a few biophysical studies reveal that the interactions of cytotoxic gold compounds with DNA are generally far weaker than those of platinum drugs, implying the occurrence of a substantially different mode of action. A variety of alternative mechanisms were thus proposed, of which those involving either direct mitochondrial damage or proteasome inhibition or modulation of specific kinases are now highly credited. The overall perspectives on the development of gold compounds as effective anticancer drugs with an innovative mechanism of action are critically discussed on the basis of the available experimental evidence.
Vehicle mounted wide FOV stereo for traffic and pedestrian detection (2005)

This paper describes an approach for detecting objects in front of an automobile using wide field of view stereo with a pair of omni cameras. Several configurations are suggested for effective detection of vehicles and pedestrians. The omni cameras are calibrated using sets of parallel lines on a parking lot. The calibration is used to rectify the omni images. Stereo matching is performed on the rectified images to detect other vehicles and pedestrians. Experimental results show promise of detecting these objects on the road.
Systematic review of optical coherence tomography usage in the diagnosis and management of basal cell carcinoma (2015)

Optical coherence tomography (OCT) is a noninvasive imaging tool used in vivo in real time for diagnosis, treatment delineation and monitoring of basal cell carcinoma (BCC). Features of BCC on OCT have been widely described and reviewed. However, the diagnostic accuracy of OCT in these various applications is unclear. We systematically reviewed the literature to assess the accuracy of OCT in diagnosis and management of BCC using the Embase and Medline databases. In total 179 unique references were identified in the initial search, of which 22 studies with 556 histologically proven BCCs were eligible. Assessment of the quality of eligible studies was undertaken using the STROBE criteria. Data extraction and quality assessment were performed independently by the two authors. This systematic review provides an overview of the clinical applications of OCT in the diagnosis and management of BCC. OCT has been suggested to be useful in the diagnosis, treatment planning and treatment monitoring of BCC. As the technology improves and its utility increases, further studies with good methodological quality will be needed to implement OCT into daily practice.
Highly structured homolog pairing reflects functional organization of the Drosophila genome (2019)

Trans-homolog interactions have been studied extensively in Drosophila, where homologs are paired in somatic cells and transvection is prevalent. Nevertheless, the detailed structure of pairing and its functional impact have not been thoroughly investigated. Accordingly, we generated a diploid cell line from divergent parents and applied haplotype-resolved Hi-C, showing that homologs pair with varying precision genome-wide, in addition to establishing trans-homolog domains and compartments. We also elucidate the structure of pairing with unprecedented detail, observing significant variation across the genome and revealing at least two forms of pairing: tight pairing, spanning contiguous small domains, and loose pairing, consisting of single larger domains. Strikingly, active genomic regions (A-type compartments, active chromatin, expressed genes) correlated with tight pairing, suggesting that pairing has a functional implication genome-wide. Finally, using RNAi and haplotype-resolved Hi-C, we show that disruption of pairing-promoting factors results in global changes in pairing, including the disruption of some interaction peaks.
RAPID ISOLATION OF PERIPHERAL BLOOD MONONUCLEAR CELLS FROM WHOLE BLOOD WITH FICOLL HYPAQUE DENSITY CENTRIFUGATION (2019)

International audience
DC pre-excitation application in three-phase induction motor drive system (2010)

Due to the current restriction of semiconductor devices, the start-up is an extremely important process in the ASD (adjustable speed drive) system. DC pre-excitation is one of the effective solutions for increasing the starting torque and depressing the starting inrush current. However the effect of DC pre-excitation would be discounted if it could not be compatible with the induction motor drive control system. Also the stability of the DC pre-excitation application is related to its operational mode. This paper addresses the principle of DC pre-excitation and excavates its relationship with current control. The method to improve the stability of DC pre-excitation effectively shielding EMI is detailed. The relevant study has been implemented in a control system for a 55 kW and 160 kW induction motor and the simulation and experimental results validate the effectiveness of the proposed design method.
Gold Nanoparticle Plasmonic Superlattices as Surface-Enhanced Raman Spectroscopy Substrates (2018)

Metal colloids are of great interest in the field of nanophotonics, mainly due to their morphology-dependent optical properties, but also because they are high-quality building blocks for complex plasmonic architectures. Close-packed colloidal supercrystals not only serve for investigating the rich plasmonic resonances arising in strongly coupled arrangements but also enable tailoring the optical response, on both the nano- and the macroscale. Bridging these vastly different length scales at reasonable fabrication costs has remained fundamentally challenging, but is essential for applications in sensing, photovoltaics or optoelectronics, among other fields. We present here a scalable approach to engineer plasmonic supercrystal arrays, based on the template-assisted assembly of gold nanospheres with topographically patterned polydimethylsiloxane molds. Regular square arrays of hexagonally packed supercrystals were achieved, reaching periodicities down to 400 nm and feature sizes around 200 nm, over areas up to 0.5 cm<sup>2</sup>. These two-dimensional supercrystals exhibit well-defined collective plasmon modes that can be tuned from the visible through the near-infrared by simple variation of the lattice parameter. We present electromagnetic modeling of the physical origin of the underlying hybrid modes and demonstrate the application of superlattice arrays as surface-enhanced Raman scattering (SERS) spectroscopy substrates which can be tailored for a specific probe laser. We therefore investigated the influence of the lattice parameter, local degree of order, and cluster architecture to identify the optimal configuration for highly efficient SERS of a nonresonant Raman probe with 785 nm excitation.