gebhart/patrepeval huggingface dataset:
Organization of rRNA genes in Mycobacterium bovis BCG (1987)

The number of rRNA genes in Mycobacterium bovis BCG was examined by Southern hybridization of end-labeled 5S, 16S, and 23S rRNAs with BamHI, PstI, and SalI digests of M. bovis BCG DNA. Each RNA probe gave only one radioactive band with three kinds of DNA digest. These results suggest that M. bovis BCG chromosomes may carry only a minimum set of rRNA genes. Hybridization of randomly labeled rRNAs with BamHI, PstI, SalI, BglII, and PvuII digests of DNA from the same organism supported these conclusions. The 6.4-kilobase-pair SalI fragment containing the entire structural genes for both 16S and 23S rRNAs was cloned into pBR322. The cloned fragment was characterized by restriction endonuclease mapping, DNA-RNA hybridization analysis, and the R-loop technique. The results indicated that the fragments contained rRNA genes in the following order: 16S, 23S, and 5S rRNA genes. No tRNA gene was detected in the spacer region between the 16S and 23S rRNA genes, but one was found downstream of the 23S rRNA and 5S rRNA genes.
Relay Architectures for 3GPP LTE-Advanced (2009)

The Third Generation Partnership Project's Long Term Evolution-Advanced is considering relaying for cost-effective throughput enhancement and coverage extension. While analog repeaters have been used to enhance coverage in commercial cellular networks, the use of more sophisticated fixed relays is relatively new. The main challenge faced by relay deployments in cellular systems is overcoming the extra interference added by the presence of relays. Most prior work on relaying does not consider interference, however. This paper analyzes the performance of several emerging half-duplex relay strategies in interference-limited cellular systems: one-way, two-way, and shared relays. The performance of each strategy as a function of location, sectoring, and frequency reuse are compared with localized base station coordination. One-way relaying is shown to provide modest gains over single-hop cellular networks in some regimes. Shared relaying is shown to approach the gains of local base station coordination at reduced complexity, while two-way relaying further reduces complexity but only works well when the relay is close to the handset. Frequency reuse of one, where each sector uses the same spectrum, is shown to have the highest network throughput. Simulations with realistic channel models provide performance comparisons that reveal the importance of interference mitigation in multihop cellular networks.
Cardiac tamponade in medical patients. (1981)

We reviewed the cases of 56 medical patients wih cardiac tamponade who were treated at the University of Cincinnati. A paradoxic arterial pulse was critical in the diagnosis because most patients did not have a small quiet heart, and blood pressure was often well maintained. Fifty-two of 55 patients had enlarged cardiac silhouette by chest radiogram; heart sounds were diminished in 19 patients; arterial systolic pressure was greater than or equal to 100 mm Hg in 35, and arterial pulse pressure was greater than or equal to 40 mm Hg in 27. Echocardiograms in 23 patients showed abnormally increased right ventricular dimensions and decreased left ventricular dimensions during inspiration, except in one patient with left ventricular dysfunction. The causes of cardiac tamponade were metastatic tumor in 18 patients, idiopathic pericarditis in eight and uremia in five; five cases of tamponade occurred after heparin administration in acute cardiac infarction. Myxedema and dissecting aneurysm each caused tamponade in two patients. Pericardiocentesis relieved tamponade initially in 40 of 46 patients; however, two suffered fatal complications. Pericardial resection was done in 18, including 12 of these 46.
Time-of-Flight Mass Spectrometry With Latching Nb Meander Detectors (2009)

Mass Spectrometry is widely used for protein characterization, structural virology, drug discovery, and clinical chemistry. However, the detection efficiency of existing detectors for mass spectrometry degrades rapidly as mass is increased, and is only ~ 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> at 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> Da. Superconducting detectors provide detection efficiency that is essentially independent of mass, and previous efforts have explored the use of superconducting tunnel junctions (STJs) and normal-insulator-superconductor (NIS) microcalorimeters as detectors. Both STJ and NIS detectors, however have active areas limited to ~ 1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , well below the ~ 1 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> required for a viable system. Microwave-interrogated microstripline meander detectors have the potential to provide the necessary area and speed. We describe such a design and present initial spectra of representative ionized biological molecules obtained from simple prototype detectors mounted on a cryocooler and interfaced to a commercial mass spectrometer.
Differential effects of nitrogen and sulfur deprivation on growth and biodiesel feedstock production of <i>Chlamydomonas reinhardtii</i> (2012)

Biodiesel production from microalgae is a promising approach for energy production; however, high cost of its process limits the use of microalgal biodiesel. Increasing the levels of triacylglycerol (TAG) levels, which is used as a biodiesel feedstock, in microalgae has been achieved mainly by nitrogen starvation. In this study, we compared effects of sulfur (S) and nitrogen (N) starvation on TAG accumulation and related parameters in wild-type Chlamydomonas reinhardtii CC-124 mt(-) and CC-125 mt(+) strains. Cell division was interrupted, protein and chlorophyll levels rapidly declined while cell volume, total neutral lipid, carotenoid, and carbohydrate content increased in response to nutrient starvation. Cytosolic lipid droplets in microalgae under nutrient starvation were monitored by three-dimensional confocal laser imaging of live cells. Infrared spectroscopy results showed that relative TAG, oligosaccharide and polysaccharide levels increased rapidly in response to nutrient starvation, especially S starvation. Both strains exhibited similar levels of regulation responses under mineral deficiency, however, the degree of their responses were significantly different, which emphasizes the importance of mating type on the physiological response of algae. Neutral lipid, TAG, and carbohydrate levels reached their peak values following 4 days of N or S starvation. Therefore, 4 days of N or S starvation provides an excellent way of increasing TAG content. Although increase in these parameters was followed by a subsequent decline in N-starved strains after 4 days, this decline was not observed in S-starved ones, which shows that S starvation is a better way of increasing TAG production of C. reinhardtii than N starvation.
Fast Intraframe Coding for High Efficiency Video Coding (2014)

The High Efficiency Video Coding (HEVC) is a new video coding standard that can provide much better compression efficiency than its predecessor H.264/AVC. However, it is computationally more intensive due to the use of flexible quadtree coding unit structure and more choices of prediction modes. In this paper, a fast intraframe coding scheme is proposed for HEVC. Firstly, a fast bottom-up pruning algorithm is designed to skip the mode decision process or reduce the candidate modes at larger block size coding unit. Then, a low complexity rough mode decision process is adopted to choose a small candidate set, followed by early DC and Planar mode decision and mode filtering to further reduce the number of candidate modes. The proposed method is evaluated by the HEVC reference software HM8.2. Averaging over 5 classes of HEVC test sequences, 41.39% encoding time saving is achieved with only 0.77% bitrate increase.
Atomic-Scale Characterization of Nitridation Processes on Si(100)-2×1 Surfaces by Radical Nitrogen (2001)

We have investigated the initial nitridation process of Si(100)-2×1 surfaces by scanning tunneling microscopy (STM) and scanning tunneling spectroscopy (STS). The nitridation was performed by radical nitrogen at a high temperature of 850°C. After the radical-nitrogen exposure of about 1 Langmuir, linear defects perpendicular to dimer rows were formed. Furthermore, doublet dark lines were frequently observed in the STM image. STS analysis of the dark-line regions clarified that the initial nitridation reaction occurs preferentially at the backbonds of surface Si atoms. Then, the nitridation proceeds via lateral growth of two-dimensional nitride-islands. These islands grow preferentially along the <011> direction perpendicular to the Si dimer rows. STS spectra obtained from the 0.5-nm-thick nitride islands distinctly showed a bandgap of about 4.0 eV that is very close to the bandgap of bulk Si 3 N 4 .
Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury. (1998)

Nonsteroidal antiinflammatory drugs such as aspirin and indomethacin are known to induce gastric mucosal damage including bleeding, ulceration, and perforation in humans and animals. Although it has been proposed that a deficiency of endogenous prostaglandins due to inhibition of cyclooxygenase by the drug is involved in these effects, the exact pathogenic mechanism remains to be elucidated. It has recently been proposed that neutrophil- and oxygen radical-dependent microvascular injuries may be important prime events that lead to mucosal injury induced by nonsteroidal antiinflammatory drugs. Lipid peroxidation mediated by oxygen radicals, especially hydroxyl radicals, plays a crucial role in the development of the gastric mucosal injury induced by indomethacin. Both allopurinol, an inhibitor of xanthine oxidase, and neutrophil depletion by intraperitoneal injection of antineutrophil antibody significantly attenuates indomethacin-induced gastric injury. In this paper, we have reviewed the recent data that assess the role of oxygen radical and lipid peroxidation in the pathogenesis of indomethacin-induced gastric mucosal injury in rats and humans.
A (DE)COLONIALIDADE DO SABER: UMA ANÁLISE A PARTIR DA UNIVERSIDADE FEDERAL DA INTEGRAÇÃO LATINO-AMERICANA (UNILA) (2014)

Dadas as inquietacoes como docentes e discentes na Universidade Federal da Integracao Latino-Americana (Unila), objetivamos com este artigo apresentar o debate sobre a Universidade em sua condicao moderna e colonial. Tendo em vista a excepcionalidade desse projeto de Instituicao de Ensino Superior (IES) no Brasil, de carater tematico e internacional, e fundamental refletir sobre sua constituicao, seus desafios e possibilidades. Para tal, realizamos uma revisao documental e bibliografica sobre o projeto da Universidade. Alem disso, baseamo-nos nas experiencias vivenciadas na instituicao e na leitura oferecida pelas perspectivas criticas a colonialidade, com uma orientacao latino-americanista de superacao do eurocentrismo. Defendemos a intensificacao de um projeto decolonial na Universidade e os horizontes para a construcao desse caminho. Adotamos uma perspectiva condizente com a formulacao teorico-metodologica que se pretende pos-positivista, antinaturalista, reflexivista e interpretativista.
Fast parallel circuits for the quantum Fourier transform (2002)

We give new bounds on the circuit complexity of the quantum Fourier transform (QFT). We give an upper bound of O(log n+log log(1//spl epsiv/)) on the circuit depth for computing an approximation of the QFT with respect to the modulus 2/sup n/ with error bounded by /spl epsiv/. Thus, even for exponentially small error, our circuits have depth O(log n). The best previous depth bound was O(n), even for approximations with constant error. Moreover, our circuits have size O(n log(n//spl epsiv/)). As an application of this depth bound, we show that P. Shor's (1997) factoring algorithm may be based on quantum circuits with depth only O(log n) and polynomial size, in combination with classical polynomial-time pre- and postprocessing. Next, we prove an /spl Omega/(log n) lower bound on the depth complexity of approximations of the QFT with constant error. This implies that the above upper bound is asymptotically tight (for a reasonable range of values of /spl epsiv/). We also give an upper bound of O(n(log n)/sup 2/ log log n) on the circuit size of the exact QFT modulo 2/sup n/, for which the best previous bound was O(n/sup 2/). Finally, based on our circuits for the QFT with power-of-2 moduli, we show that the QFT with respect to an arbitrary modulus m can be approximated with accuracy /spl epsiv/ with circuits of depth O((log log m)(log log 1//spl epsiv/)) and size polynomial in log m+log(1//spl epsiv/).
Investigation of the Gas Detection Mechanism in Semiconductor Chemical Sensors by FTIR Spectroscopy (2005)

In this review article, we focus on two complementary approaches of Fourier transform infrared (FTIR) spectroscopic analysis of semiconductors, in an attempt to bridge a gap between the “atomistic model” and the “rigid band model.” First, we report on selected papers describing the chemical reactions occurring at the surface of semiconductor chemical gas sensors. Then, we mention different studies in which FTIR spectroscopy has been used to monitor the free carrier absorption in semiconductors. Finally, to correlate surface chemistry with electronic properties, we describe our approach combining both possibilities offered by FTIR spectroscopy. This approach allows one to clarify the fundamentals of the gas detection mechanisms and to obtain an unequivocal and rapid correlation between the electrical response of the chemical sensors and the infrared absorption of sensing semiconductors.
Electrical characterization of ITO/p-InP solar cells (2002)

Indium tin oxide (ITO)/p-InP solar diodes were fabricated by RF magnetron sputtering with variables of hydrogen during deposition, substrate temperature and in one case, an 80 /spl Aring/ Sn:In layer between ITO and InP. Analysis by current-voltage-temperature and spectroscopic techniques reveal the healing effect of adding H/sub 2/ during deposition of ITO. Higher substrate temperature during ITO deposition gives improved ITO films but induces more surface defects. Current conduction is predominantly by thermionic emission. An 80 /spl Aring/ In:Sn layer between InP and ITO causes a significant change in all measured data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Variation of Serine-Aspartate Repeats in Membrane Proteins Possibly Contributes to Staphylococcal Microevolution (2012)

Tandem repeats (either as microsatellites or minisatellites) in eukaryotic and prokaryotic organisms are mutation-prone DNA. While minisatellites in prokaryotic genomes are underrepresented, the cell surface adhesins of bacteria often contain the minisatellite SD repeats, encoding the amino acid pair of serine-asparatate, especially in Staphylococcal strains. However, their relationship to biological functions is still elusive. In this study, effort was made to uncover the copy number variations of SD repeats by bioinformatic analysis and to detect changes in SD repeats during a plasmid-based assay, as a first step to understand its biological functions. The SD repeats were found to be mainly present in the cell surface proteins. The SD repeats were genetically unstable and polymorphic in terms of copy numbers and sequence compositions. Unlike SNPs, the change of its copy number was reversible, without frame shifting. More significantly, a rearrangement hot spot, the ATTC/AGRT site, was found to be mainly responsible for the instability and reversibility of SD repeats. These characteristics of SD repeats may facilitate bacteria to respond to environmental changes, with low cost, low risk and high efficiency.
Active, Passive and Dynamic Shielding of Static and Low Frequency Magnetic Fields (2009)

Three kinds of static and low-frequency magnetic fields shielding are known, namely, active, passive and dynamic. In this paper we discuss each of them, while a special emphasis is put on active shielding. Such a shielding uses coils with currents that generate magnetic fields of the same frequency and amplitude as the external field but in the opposite direction. From mathematical point of view these problems belong to ill posed nonlinear inverse problems and require special treatment. A method for designing a shape of the coils is given in the paper.
Teenagers in the United States: sexual activity, contraceptive use, and childbearing, national survey of family growth 2006-2008. (2010)

In 2006-2008, about 42% of never-married female teenagers (4.3 million), and about 43% of never-married male teenagers (4.5 million) had had sexual intercourse at least once. These levels of sexual experience have not changed significantly from 2002, the last time the NSFG collected these data. Among never-married teenagers, 79% of females and 87% of males used a method of contraception at first sex. With a few exceptions, teenagers' use of contraceptives has changed little since 2002, and the condom remained the most commonly used method. One exception was an increase in the use of condoms and the use of a condom combined with a hormonal contraceptive (dual method use) among males. Another exception was a significant increase in the percent of female teenagers who had ever used periodic abstinence, or the "calendar rhythm" method. This method had been used by 17% of female teenagers in 2006-2008.
Correlated Time Series Forecasting using Multi-Task Deep Neural Networks (2018)

Cyber-physical systems often consist of entities that interact with each other over time. Meanwhile, as part of the continued digitization of industrial processes, various sensor technologies are deployed that enable us to record time-varying attributes (a.k.a., time series) of such entities, thus producing correlated time series. To enable accurate forecasting on such correlated time series, this paper proposes two models that combine convolutional neural networks (CNNs) and recurrent neural networks (RNNs). The first model employs a CNN on each individual time series, combines the convoluted features, and then applies an RNN on top of the convoluted features in the end to enable forecasting. The second model adds additional auto-encoders into the individual CNNs, making the second model a multi-task learning model, which provides accurate and robust forecasting. Experiments on a large real-world correlated time series data set suggest that the proposed two models are effective and outperform baselines in most settings.
A randomized trial comparing the ovulation induction efficacy of clomiphene citrate and letrozole (2014)

Although letrozole is used for ovulation induction in anovulatory infertility, no significant beneficial effects of letrozole compared to use of clomiphene citratewere observedin ourstudy. Hence, we concur with the use of clomiphene citrate as the first line of drug for ovulation induction in Indian population and warrant larger size studiesto further validate our results.
Single Byte Error Correcting&#8212;Double Byte Error Detecting Codes for Memory Systems (1982)

In a memory that uses byte-organized memory chips, each containing b (≥2) output bits, a single chip failure is likely to affect many bits within a byte. Single byte error correcting–double byte error detecting codes (SbEC–DbED codes) are used in this kind of memory system to increase reliability.
Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy (2018)

Selective delivery of photosensitizers to mitochondria of cancer cells can enhance the efficacy of photodynamic therapy (PDT). Though cationic Ru-based photosensitizers accumulate in mitochondria, they require excitation with less penetrating short-wavelength photons, limiting their application in PDT. We recently discovered X-ray based cancer therapy by nanoscale metal-organic frameworks (nMOFs) via enhancing radiotherapy (RT) and enabling radiodynamic therapy (RDT). Herein we report Hf-DBB-Ru as a mitochondria-targeted nMOF for RT-RDT. Constructed from Ru-based photosensitizers, the cationic framework exhibits strong mitochondria-targeting property. Upon X-ray irradiation, Hf-DBB-Ru efficiently generates hydroxyl radicals from the Hf<sub>6</sub> SBUs and singlet oxygen from the DBB-Ru photosensitizers to lead to RT-RDT effects. Mitochondria-targeted RT-RDT depolarizes the mitochondrial membrane to initiate apoptosis of cancer cells, leading to significant regression of colorectal tumors in mouse models. Our work establishes an effective strategy to selectively target mitochondria with cationic nMOFs for enhanced cancer therapy via RT-RDT with low doses of deeply penetrating X-rays.
Nuclear topography of the 1q21 genomic region and Mcl-1 protein levels associated with pathophysiology of multiple myeloma (2009)

Chromosomal rearrangements and copy number variation are frequently observed in cancer cells, including multiple myeloma (MM). Karyotypic abnormalities seen in MM cells correlate with the disease stage and drug responses. Here, we investigate the nuclear arrangement of the 1q21 region; amplification of this region is an important diagnostic and prognostic marker of MM. We examined the lymphoblastoid cell line CD138- ARH-77, multiple myeloma CD138+ MOLP-8 cells, and the CD138+ bone marrow fraction of patients diagnosed with MM. In this experimental system, we observed that gamma-radiation and selected cytostatic drugs such as melphalan and dexamethasone did not significantly alter the nuclear radial arrangement of the 1q21 region and other relevant regions of chromosome 1. Similarly, conserved nuclear radial positioning after cytostatic treatment was observed for the c-myc, TP53, CCND1, and IgH loci. When analyzed Mcl-1, a protein encoded by a gene mapped to the 1q21 region, we found that the variant Mcl1S is highly expressed in multiple myeloma MOLP-8 cells, but not in peripheral blood lymphocytes of healthy donors or lymphoblastoid ARH-77 cells; this is in contrast to the expression pattern of the Mcl-1L variant. On the basis of these observations we suggest that the 1q21 region is an important diagnostic marker of MM, particularly the gene encoding the Mcl-1S variant, which can be easily detected by western analysis.
Molecular mechanisms of osmosis (1989)

Osmosis across a semipermeable membrane is usually treated in terms of thermodynamics, but the equations for osmosis can also be derived from kinetic considerations. Since fewer solvent molecules bombard the semipermeable membrane from the solution side, a kinetic pressure difference (osmotic potential) is generated into pore openings. Intermolecular forces cancel each other and do not affect the osmotic potential. On the other hand, osmotic flow is dependent on intermolecular cohesive forces permitting the generation of large negative pressures in the membrane pores. Osmosis is therefore a unique property of liquids, whereas intermolecular cohesive forces do not affect diffusion. Osmotic pressure up to 180 atm can be correctly determined from the reduction in saturated vapor pressure above the solution because osmotic pressure and reduction in vapor pressure to some extent are analogous phenomena. Osmotic pressures up to 180 atm may also be correctly determined from kinetic considerations by accounting for binding between solvent and solute molecules (4-5 water molecules per solute molecule for sucrose solutions).
Mechanism of Action of Kirromycin-Like Antibiotics (1985)

Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly pathogenic HCoVs: severe acute respiratory syndrome coronavirus (SARS-CoV) and ...Read More