gebhart/patrepeval huggingface dataset:
Comparative study of new benzenesulphonamide fluoroquinolones structurally related to ciprofloxacin against selected ciprofloxacin-susceptible and -resistant Gram-positive cocci (2001)

The in vitro activities of benzenesulphonamide fluoroquinolones (BSFQs) I-III, new fluoroquinolones with a p-substituted benzenesulphonyl moiety attached to the C(7) piperazinyl ring of ciprofloxacin, were assessed in comparison with those of N-sulfanilylpiperazinyl fluoroquinolone (NSFQ)-105 and ciprofloxacin for 133 Gram-positive clinical isolates. NSFQ-105 and BSFQ-I were the most active drugs. They were 16- to 64-fold more active than ciprofloxacin against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, including ciprofloxacin-resistant strains, and Streptococcus pneumoniae (eight- to 32-fold). A high degree of correlation was found between the MICs of the new compounds and ciprofloxacin for Staphylococcus spp. and E. faecalis. Staphylococci and enterococci exhibit cross-resistance to BSFQs and ciprofloxacin.
Hybrid magnetoresistance in the proximity of a ferromagnet (2013)

We report a new magnetoresistance (MR) effect observed in a nominally nonmagnetic metal (Pt) thin film in contact with either a ferromagnetic insulator or a ferromagnetic metal. The resistivities with in-plane magnetic fields parallel (${\ensuremath{\rho}}_{\ensuremath{\parallel}}$) and transverse (${\ensuremath{\rho}}_{\mathrm{T}}$) to a current and a perpendicular field (${\ensuremath{\rho}}_{\ensuremath{\perp}}$) show the behavior of ${\ensuremath{\rho}}_{\ensuremath{\perp}}$ \ensuremath{\approx} ${\ensuremath{\rho}}_{\ensuremath{\parallel}}$ > ${\ensuremath{\rho}}_{\mathrm{T}}$, distinctly different from all other known MR effects, including anisotropic MR with ${\ensuremath{\rho}}_{\ensuremath{\parallel}}$ > ${\ensuremath{\rho}}_{\mathrm{T}}$ \ensuremath{\approx} ${\ensuremath{\rho}}_{\ensuremath{\perp}}$. We termed the new MR as hybrid MR, which appears in a metal in close proximity with a ferromagnet either insulating or metallic, and is associated with the induced magnetic moments at the interface.
Antitumor activity of glyceryl ethers. (1972)

Antitumor activity of fatty alcohols and a -glyceryl ethers of fatty alcohols was examined with Ehrlich carcinoma in mice. Significant antitumor activity was exerted against Ehrlich ascites carcinoma by i.p. administration of capryl, lauryl, and myristyl a -glyceryl ethers. Capryl and lauryl glyceryl ethers suppressed the growth of solid tumor when administered through various routes. Administration s.c. was the most effective.
Primary Surface Recuperator for High Performance Prime Movers (1992)

<div class="htmlview paragraph">A recuperator used in advanced vehicular gas turbines must satisfy the space, weight, dynamic loads, and part power performance requirements. To meet the overall power plant requirements, the gas turbine must be designed with a high pressure ratio and a high turbine inlet temperature. The operating conditions together with cyclic operation of vehicular power plants requires a recuperator with a dense primary heat transfer surface, strong alloys, and increased resistance to thermal and mechanical strains.</div> <div class="htmlview paragraph">Solar's Primary Surface Recuperator (PSR) is a unique heat exchanger technology. Developed for vehicular applications, the PSR incorporates design features that give reliable operation in high cyclic environments. The high heat transfer surface density in the PSR gives high performance, low weight and volume, reduced noise emissions, and low cost.</div>
Apparatus (1957)

F. J. Spillane, Analyst, 1957, 82, 712 DOI: 10.1039/AN9578200712
Oligonucleotide Array-Based Identification of Species in the <i>Acinetobacter calcoaceticus-A. baumannii</i> Complex in Isolates from Blood Cultures and Antimicrobial Susceptibility Testing of the Isolates (2008)

Acinetobacter calcoaceticus, A. baumannii, Acinetobacter genomic species (gen. sp.) 3, and Acinetobacter gen. sp. 13TU, which are included in the A. calcoaceticus-A. baumannii complex, are difficult to distinguish by phenotypic methods. An array with six oligonucleotide probes based on the 16S-23S rRNA gene intergenic spacer (ITS) region was developed to differentiate species in the A. calcoaceticus-A. baumannii complex. Validation of the array with a reference collection of 52 strains of the A. calcoaceticus-A. baumannii complex and 137 strains of other species resulted in an identification sensitivity and specificity of 100%. By using the array, the species distribution of 291 isolates of the A. calcoaceticus-A. baumannii complex from patients with bacteremia were determined to be A. baumannii (221 strains [75.9%]), Acinetobacter gen. sp. 3 (67 strains [23.0%]), Acinetobacter gen. sp. 13TU (2 strains [0.7%]), and unidentified Acinetobacter sp. (1 strain [0.3%]). The identification accuracy of the array for 12 randomly selected isolates from patients with bacteremia was further confirmed by sequence analyses of the ITS region and the 16S rRNA gene. Antimicrobial susceptibility testing of the 291 isolates from patients with bacteremia revealed that A. baumannii strains were less susceptible to antimicrobial agents than Acinetobacter gen. sp. 3. All Acinetobacter gen. sp. 3 strains were susceptible to ampicillin-sulbactam, imipenem, and meropenem; but only 67.4%, 90%, and 86% of the A. baumannii strains were susceptible to ampicillin-sulbactam, imipenem, and meropenem, respectively. The observed significant variations in antimicrobial susceptibility among different species in the A. calcoaceticus-A. baumannii complex emphasize that the differentiation of species within the complex is relevant from a clinical-epidemiological point of view.
Crosstalk Between Autophagy and Apoptosis in Heart Disease (2008)

Autophagy is a cell survival mechanism that involves degradation and recycling of cytoplasmic components, such as long-lived proteins and organelles. In addition, autophagy mediates cell death under specific circumstances. Apoptosis, a form of programmed cell death, has been well characterized, and the molecular events involved in apoptotic death are well understood. Damaged cardiomyocytes that show characteristics of autophagy have been observed during heart failure. However, it remains unclear whether autophagy is a sign of failed cardiomyocyte repair or is a suicide pathway for the failing cardiomyocytes. Although autophagy and apoptosis are markedly different processes, several pathways regulate both autophagic and apoptotic machinery and autophagy can cooperate with apoptosis. This review summarizes the evidence for crosstalk between autophagy and apoptosis.
A 16*1 wavelength division multiplexer with integrated distributed Bragg reflector lasers and electroabsorption modulators (1993)

The integrated operation of a 16*1 wavelength-division-multiplexed (WDM) source with distributed Bragg reflector (DBR) lasers and electroabsorption modulators has been demonstrated. By using repeated holographic exposures and wet chemical etching, 16 different wavelengths from 1.544 to 1.553 mu m with an average channel spacing of 6 AA are obtained. A high-performance combiner is used to obtain a very uniform coupling into the single-output waveguide, and with the integration of an optical amplifier an average optical power of -8 dBm per channel is coupled into a single-mode fiber.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nanoporous Metal Enhanced Catalytic Activities of Amorphous Molybdenum Sulfide for High‐Efficiency Hydrogen Production (2014)

We fabricated a robust electrocatalyst by chemically depositing an ultrathin layer of amorphous molybdenum sulfide on the internal surface of dealloyed nanoporous gold. The catalyst exhibits superior electrocatalysis toward hydrogen evolution reaction in both acidic and neutral media with 2-6 times improvement in catalytic activies compared to other molybdenum sulfide based materials.
Optimization of process for reduction of antinutritional factors in edible cereal brans (2012)

Reduction of various antinutritional factors in cereal brans by different treatments (microwave heating, dry heating and wet heating) were studied. There was significant difference (p ≤ 0.05) in reduction of antinutritional factors of treated cereal brans except for dry heating at low temperature. Microwave heating at 2450 MHz for 2.5 min resulted in 53.85%, 57.21%, 65.00% and 100% reduction in phytic acid, polyphenols, oxalates and saponins, respectively. Wet heating resulted in maximum reduction in trypsin inhibitor activity (83.07%) at 110 °C for 25 min. Processing treatment resulted in increase in bulk density and slight darkening of the brans. The most effective method of detoxifying most of the toxicants was microwave heating for 2.5 min, and therefore it could be exploited for making treated brans an ideal source for potential food application.
Transforming growth factor beta inhibits endomitosis in the Dami human megakaryocytic cell line (1990)

Megakaryocyte development is a carefully controlled process that is at least partially regulated by cytokines. Previous investigations of megakaryocyte development have focused primarily on defining growth factors that induce or enhance differentiation. In this study we demonstrate that a specific cytokine, transforming growth factor beta 1 (TGF beta 1), inhibits the phorbol myristate acetate (PMA)-induced differentiation of the Dami human megakaryocytic cell line. The addition of purified platelet TGF beta 1 inhibits PMA-induced endomitosis in a dose-dependent manner. Inhibition of endomitosis occurs with as little as 0.4 pmol/L TGF beta 1, is half-maximal at 6.4 pmol/L, and is maximal between 40 and 200 pmol/L TGF beta 1. Inhibition does not require other growth factors or nonmegakaryocytic cells. Removal of TGF beta 1 from the cultures decreases inhibition, suggesting that the continuous presence of TGF beta 1 is required and that its effects are reversible. This effect occurs even though the Dami cells constitutively express TGF beta 1 messenger RNA (mRNA) and the TGF beta 1 mRNA levels are increased by PMA. TGF beta 1 also has been shown to inhibit endomitosis during short-term culture of primary human megakaryocytes. These results suggest a model in which negative as well as positive regulatory factors modulate a critical stage of megakaryocyte development.
The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life (1990)

Research Article| July 01 1990 The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life P J Thornalley P J Thornalley 1Department of Chemistry and Biological Chemistry, University of Essex, Wivenhoe Park, Colchester, Essex C04 3SQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1990) 269 (1): 1–11. https://doi.org/10.1042/bj2690001 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation P J Thornalley; The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life. Biochem J 1 July 1990; 269 (1): 1–11. doi: https://doi.org/10.1042/bj2690001 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1990 London: The Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Ultrasound backscatter microscope analysis of mouse melanoma progression (1996)

The incidence and mortality rate of cutaneous melanoma continue to increase throughout the world, making the study of melanoma biology an important area of current research. While recent breakthroughs in transgenic mouse technology have led to promising mouse skin models of melanoma, there is presently no technique available for quantitatively studying subsurface melanoma progression, in vivo. We demonstrate the first application of an imaging method called ultrasound backscatter microscopy (UBM) for imaging early murine melanomas with spatial resolution of 30 microns axial and 60 microns lateral. Murine B16 F10 melanomas have been imaged from their earliest detection, over several days, until they are 2 to 5 mm in diameter. Melanoma dimensions measured by UBM were found to be in excellent agreement with those determined histopathologically on the excised tumours. The relative rms errors in UBM-determined melanoma height and width were found to be 8.7% and 4.2%, respectively. The mean rate of increase in tumour height of early murine melanoma was found to be 0.37 +/- 0.06 mm/day. Computer-generated volumetric renderings of melanomas have been produced from three-dimensional image data, allowing quantitative comparisons of tumour volumes to be made. Using a priori assumptions of ellipsoid tumour shape, the relative error in UBM-determined volume was shown to be less than 17%. These results should be of considerable interest to investigators studying melanoma biology using mouse skin models, and have implications in the use of high frequency ultrasound imaging for the clinical assessment of cutaneous melanoma.
Structure-Based Design of Grp94-Selective Inhibitors (2014)

Heat shock protein 90 KDa (Hsp90) belongs to family of proteins called molecular chaperone that are associated with protein folding and maturation. Hsp90 clients play a critical role in the pathogenesis of diseases such as cancer, neurodegeneration and infection. Currently, clinical trials are underway for various Hsp90 inhibitors, however, all of these inhibitors exhibit paninhibition of all four Hsp90 isoforms, which could be the cause of side effects observed with these inhibitors, including, hepatotoxicity, cardiotoxicity, and renal toxicity. Hence, the development of isoform selective Hsp90 inhibitor is needed to delineate the role each Hsp90 isoform plays towards the pathogenesis of these toxicities. One such isoform is the ER residing glucose regulated protein (Grp94), which is important for cellular communication and adhesion. Co-crystallization studies of radamide, an Hsp90 pan-inhibitor developed in our lab established that there exists a unique hydrophobic pocket found only in Grp94. To probe this pocket, two approaches have been investigated; 1) des-quinone analogs of radamide and 2) employing cis-amide isosteres. The co-crystal structure of cis-amide isostere compound BnIm bound to Gp94 and Hsp90 led to the discovery of a novel pocket in Grp94 due to ligand induced conformational change. This pocket has been probed by the modification of SNX 2112, a pan-inhibitor of Hsp90 that is currently undergoing clinical evaluation. These modifications have resulted in the identification of ACO1, which exhibits good potency and high selectivity towards Grp94. Rationale for the design of ACO analogs is discussed alongside their inhibition activities.
Antagonism by Cortisone of the Linear Growth Induced in Hypopituitary Patients and Hypophysectomized Rats by Human Growth Hormone1 (1965)

An 18-yr-old panhypopituitary male failed to grow while receiving “physiologic” doses of desiccated thyroid, cortisone and human growth hormone (HGH). A growth response began within 2 weeks of discontinuing cortisone acetate (2.5 mg tid). The second patient was an 18½-yr-old hypopituitary female who had maintained a normal growth rate during 27 months of HGH therapy. Cortisone acetate (5 mg tid) caused complete cessation of growth over the 3½-month period of administration. Growth promptly resumed when cortisone was discontinued. Studies with hypophysectomized rats treated with HGH and varying doses of cortisone confirmed these clinical observations and indicated that cortisone competitively inhibits growth hormone. It is concluded that concurrent administration of cortisone limits the beneficial growth-promoting effects of HGH in hypopituitary subjects. Furthermore, these observations probably explain in part the growth inhibition seen in treatment of normal children with pharmacologic doses of corticosteroids.
Associations between serum total bilirubin levels and functional dependence in the elderly (2011)

Higher serum total bilirubin levels were associated with lower likelihood of functional dependence in older adults.
STUDY OF 4-MONO- AND 4,4-DISUBSTITUTED-3-IMINO-2-BENZOYL-5-PYRAZOLONES (1952)

4-Mono- and 4,4-disubstituted-3-imino-2-benzoyl-5-pyrazolones have been prepared from the corresponding ethyl mono- or disubstituted cyanoacetates and N-benzoylhydrazine. The presence of the imino group in 4,4-disubstituted-3-imino-2-benzoyl-5-pyrazolones was ascertained by the hydrolysis of 4,4-dibenzyl-3-imino-2-benzoyl-5-pyrazolone into 4,4-dibenzyl-3-oxo-2-benzoyl-5-pyrazolone. In order to prove that the benzoyl group in these pyrazolones was not in Position 1, the synthesis of 4-benzyl-3-amino-1-benzoyl-5-pyrazolone was attempted from 4-benzyl-3-carbethoxy-1-benzoyl-5-pyrazolone through a Curtius degradation of the 3-carbethoxy substituent into a 3-amino group. It was found that the 1-benzoyl group was hydrolyzed at the same time as the 3-carbethoxyamino substituent. The ultraviolet absorption spectra of all these compounds are reported and discussed briefly.
John Scott Haldane, 1860-1936 (1936)

Abstract John Scott Haldane was born in Edinburgh on 3 May, 1860, the son of Robert Haldane, of Cloan, Auchterarder, and Mary Burdon Sanderson, and brother of Lord Haldane, Sir W. S. Haldane, and Elizabeth Haldane. The centuries-old family of the Haldanes of Gleneagles can count among its members many who have been held in honour in their own time and whose reputation has been lasting, and to this record the branch of the family, the Haldanes of Cloan, was destined to add further distinction. The death of John Haldane on 15 March, 1936, has meant the loss of one who for many years has had a profound influence on the development of both pure and applied physiology, for he was one of those rare men of outstanding genius whose work has implications which extend over a far wider range than the immediate field of their inquiries and results in a change in the whole trend of scientific thought.
Feasibility of multiple short, 40-s, intra-procedural ECG recordings to detect immediate changes in heart rate variability during catheter ablation for arrhythmias (2011)

Averaging multiple 40-s windows give valid HF and LF HRV measurements that enable detection of intra-procedural changes. Left atrial ablation around the right-sided pulmonary veins is unique in producing reductions in HRV. This method has the potential for use as an endpoint marker for adjunctive autonomic ablation procedures.
KIF13B regulates angiogenesis through golgi-plasma membrane trafficking of VEGFR2 (2014)

Although the trafficking of newly synthesized VEGFR2 to the plasma membrane is a key determinant of angiogenesis, the molecular mechanisms of Golgi to plasma membrane trafficking are unknown. Here, we have identified a key role of the kinesin family plus-end molecular motor KIF13B in delivering VEGFR2 cargo from the Golgi to the endothelial cell surface. KIF13B is shown to interact directly with VEGFR2 on microtubules. We also observed that overexpression of truncated versions of KIF13B containing the binding domains that interact with VEGFR2 inhibited VEGF-induced capillary tube formation. KIF13B depletion prevented VEGF-mediated endothelial migration, capillary tube formation and neo-vascularization in mice. Impairment in trafficking induced by knockdown of KIF13B shunted VEGFR2 towards the lysosomal degradation pathway. Thus, KIF13B is an essential molecular motor required for the trafficking of VEGFR2 from the Golgi, and its delivery to the endothelial cell surface mediates angiogenesis.
Central line exit sites: which dressing? (1998)

Recent developments in dressings for intravenous access sites include a transparent dressing which does not retain moisture. This article describes a randomised controlled trial to compare the new dressing with a standard dressing. There was no difference in sepsis rates between the two groups, and both methods had advantages and disadvantages. The authors suggest that cost may be a factor in choice of dressing.
Temperature controlled logistics : provide or perish (2007)

Subtitle: Whether shipping fruit, seafood, flowers, or any other perishable goods, transportation must be fresh, fast, and error-free.
Soup and printers’ ink (1966)

To sell at a price most people are willing to pay, and even to exist at all, the newspapers must offer space in their columns for advertising.KeywordsQuality PaperRail FreightLate NewsAdvertising RatePopular PaperThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Effects of aging and regular exercise on the visual functions. (2005)

目的: 視機能について, 年齢と運動習慣の違いを基準とした対象群を設け, 8項目に関する機能測定を実施し, その比較検討を行った. 対象・方法: 運動習慣を持つ男性30名と運動習慣を持たない男性30名を対象として行った. 運動習慣群とは剣道を週3回以上行っている若年群 (年齢21.0±0.6歳, 剣道歴13.5±1.7年) 10名, 中年群 (年齢41.1±1.7歳, 剣道歴32.0±2.4年) 10名, 高年群 (年齢63.3±2.1歳, 剣道歴49.2±1.1年) 10名とし, 非運動習慣群は, 若年群 (年齢20.9±1.1歳) 10名, 中年群 (年齢41.1±4.2歳) 10名, 高年群 (年齢64.2±2.5歳) 10名である. 結果: コントラスト感度・眼球運動・瞬間視力の各能力については, 加齢および運動習慣の違いで差はみられなかった. また, コントラスト感度は静止視力との相関が強くみられた. それに対し前後方向動体視力 (KVA), 深視力の各能力は, 加齢による有意な低下がみられた. また, 横方向動体視力 (DVA), 眼と手の協応運動の各能力は, 加齢に伴う低下がみられたが, 運動習慣を持つ者が持たない者より有意に優れている結果がみられた. 結論: コントラスト感度は適正な視力矯正がその能力を向上させる要因であると思われる. それに対し前後方向動体視力 (KVA), 深視力は加齢が能力低下に影響を及ぼす一要因であることが示唆された. また, 横方向動体視力 (DVA), 眼と手の協応運動の各能力は, 加齢に伴い低下するが, 運動習慣によってその低下スピードを鈍化させる効果があることが判明した.
LDACS: future aeronautical communications for air-traffic management (2014)

A major modernization process in air traffic management for civil aviation is currently taking place under the framework of SESAR and NextGen in Europe and the United States, respectively. Air traffic management modernization is required to meet the needs sustainable air traffic growth in Europe, the United States, and worldwide are posing. A key enabler for this modernization process is the introduction of improved communications, navigation, and surveillance technologies. In this article, new developments in aeronautical communications for air traffic management are presented, with special focus on the air/ground communications technology L-band Digital Aeronautical Communications System (LDACS). The most promising LDACS technology candidate, LDACS1, is described in detail, and possible extensions toward navigation and surveillance are discussed. With these extensions, LDACS1 is well placed to become the first integrated communications, navigation, and surveillance technology for civil aviation. Utilizing a common ground infrastructure, such an integrated approach simplifies deployment and reduces costs for both deployment and maintenance.