gebhart/patrepeval huggingface dataset:
Transitive node similarity for link prediction in social networks with positive and negative links (2010)

Online social networks (OSNs) like Facebook, and Myspace recommend new friends to registered users based on local features of the graph (i.e. based on the number of common friends that two users share). However, OSNs do not exploit the whole structure of the network. Instead, they consider only pathways of maximum length 2 between a user and his candidate friends. On the other hand, there are global approaches, which detect the overall path structure in a network, being computationally prohibitive for huge-size social networks. In this paper, we define a basic node similarity measure that captures effectively local graph features. We also exploit global graph features introducing transitive node similarity. Moreover, we derive variants of our method that apply in signed networks. We perform extensive experimental comparison of the proposed method against existing recommendation algorithms using synthetic and real data sets (Facebook, Hi5 and Epinions). Our experimental results show that our FriendTNS algorithm outperforms other approaches in terms of accuracy and it is also time efficient. We show that a significant accuracy improvement can be gained by using information about both positive and negative edges.
Experiences in Using Immersive Virtual Characters to Educate Medical Communication Skills (2006)

This paper presents a system which allows medical students to experience the interaction between a patient and a medical doctor using natural methods of interaction with a high level of immersion. We also present our experiences with a pilot group of medical and physician assistant students at various levels of training. They interacted with projector-based life-sized virtual characters using gestures and speech. We believe that natural interaction and a high level of immersion facilitates the education of communication skills. We present the system details as well as the participants' performance and opinions. The study confirmed that the level of immersion contributed significantly to the experience, and participants reported that the system is a powerful tool for teaching and training. Applying the system to formal communication skills evaluation and further scenario development will be the focus of future research and refinement.
Phosphatase inhibition in human neuroblastoma cells alters tau antigenicity and renders it incompetent to associate with exogenous microtubules (1996)

The abnormal cytoskeletal organization observed in Alzheimer's disease has been suggested to arise from hyperphosphorylation of tau and the resultant elimination of its ability to associate with microtubules. This possibility has been supported by a number of studies under cell-free conditions utilizing various kinases, phosphatases and their corresponding inhibitors each, and by treatment of intact cells with kinase and phosphatase activators and inhibitors. However, in studies utilizing intact cells, it remained difficult to attribute microtubule compromise specifically to tau hyperphosphorylation due to potential influence of inhibitors on tubulin and/or other microtubule-associated proteins which themselves possess assembly-regulatory phosphorylation sites. To address this difficulty, we subjected SH-SY-5Y human neuroblastoma cells to treatment with the phosphatase inhibitor okadaic acid (OA), which has been previously demonstrated to depolymerize microtubules in these cells. OA induced an increase in tau hyperphosphorylation as evidenced by an increase in Alz-50 immunoreactivity and a corresponding decrease in Tau-1 immunoreactivity. When tau-enriched fractions from OA-treated cells were incubated under microtubule assembly-promoting conditions with twice-cycled, tau-free preparations of bovine brain tubulin not exposed to OA, Alz-50-immunoreactive tau isoforms displayed a marked (49%) reduction in ability to co-assemble with bovine microtubules as compared with Tau-1- and 5E2-immunoreactive isoforms. These data indicated that hyperphosphorylated tau has a reduced capacity to associate with microtubules, and support the hypothesis that tau hyperphosphorylation may underlie microtubule breakdown in Alzheimer's disease.
Partial Lock Remote Procedure Call (RPC) for NETCONF (2009)

The Network Configuration protocol (NETCONF) defines the lock and unlock Remote Procedure Calls (RPCs), used to lock entire configuration datastores. In some situations, a way to lock only parts of a configuration datastore is required. This document defines a capability-based extension to the NETCONF protocol for locking portions of a configuration datastore.
Molecular Transporter Between Polymer Platforms: Highly Efficient Chemoenzymatic Glycopeptide Synthesis by the Combined Use of Solid‐Phase and Water‐Soluble Polymer Supports (2005)

The molecule standing at platform one …︁: Rapid glycopeptide synthesis is achieved with a heterobifunctional “molecular transporter” (see scheme), which interfaces two types of polymer platforms for combined chemical and enzymatic synthesis. This linker allows both chemoselective blotting and photoselective cleavage of the glycopeptides. Red: sugar residues; green: amino acid residues. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z463065_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
O4–06–04: Intraneuronal Abeta42 aggregates seed amyloid plaques and cause neuronal loss in transgenic mice with five familial Alzheimer's disease mutations (2006)

Amyloid plaques, composed of beta–amyloid 42 (Abeta42), are defining lesions in Alzheimer's disease (AD), yet how they form and relate to neuronal loss in AD is unknown. Familial AD mutations in amyloid precursor protein (APP) and presenilins (PS1 and PS2) cause early onset AD and increase Abeta42 production, strongly suggesting that Abeta42 promotes AD pathogenesis and plaque formation. In addition, Abeta42–elevating mutations when combined in the same molecule additively increase Abeta42 production in vitro, suggesting a novel transgenic approach for driving very high Abeta42 levels and early amyloid deposition in the brain. Here, we made transgenic mice that co–express 5 familial AD mutations (5XFAD mice) to additively drive Abeta42 overproduction for studying the effects of very high cerebral Abeta42 levels on amyloid plaque formation and neurodegeneration. Thy1 promoter–driven transgenes expressing APP K670N/M671L (Swedish) + I716V (Florida) + V717I (London) and PS1 M146L+ L286V were co–injected into single cell mouse embryos to generate co–integrated, bigenic mice that bred as single transgenics. Mice were sacrificed at different ages and analyzed for amyloid pathology, neurodegeneration, and behavior using standard methods. 5XFAD mice generate Abeta42 almost exclusively. In 5XFAD brain, we observe intraneuronal Abeta42 accumulation at 1.5 months of age, before amyloid plaques form at 2 months. Importantly, intraneuronal Abeta42 aggregates occur in neuron soma and neurites and appear to seed amyloid deposits. Moreover, 5XFAD synaptophysin levels are dramatically reduced, correlating with impaired Y–maze performance, and profound neuron loss occurs in cortical layer 5 and subiculum. These results strongly suggest that intraneuronal Abeta42 aggregates cause neurodegeneration and neuron lysis, and aggregates thus released act as seeds for plaques. This model provides a coherent explanation for both neuronal loss and plaque genesis and suggests reduction of intraneuronal Abeta should be beneficial for AD.
Study on the Functional Dynamic Changes of Peri-Operative Cellular Immunity in Esophageal and Cardiac Cancer (2014)

Objective: To explore the systemic and local cellular immune function of patients with esophageal carcinoma or cardiac cancer. Methods: The distribution of tumor-infiltrating lymphocyte (TIL) and cancer-associated macrophage (TAM) in local tumor tissues of 52 patients with esophageal cancer or cardiac cancer were observed by immunehistochemical method. The level of peripheral SIL-2R and TNF-α of preoperative and postoperative 1, 2, 3 weeks were detected by ELISA and ABC-ELISA methods respectively, then the acquired results were compared with 30 cases of normal control group. Results: The peritumor infiltration densities of TIL and TAM was greater than that of cancer nest stroma (P ＜ 0.05). Compared with the normal control group, the levels of sIL-2R and TNF-α increased significantly (P ＜ 0.01). Immune function could be suppressed by operative wound in a short time of post-operation, whose damage severity was closely associated with tumor TNM stages. Conclusion: Patients with esophageal or cardiac cancer have cellular immune function disorders. Dynamic testing of peripheral sIL-2R and TNT-α level in patients with esophageal or cardiac cancer has positive clinical significance in the evaluation of cellular immune function, tumor lesion degree and curative effect.
Accounting Federated Clouds Based on the JiTCloud Platform (2013)

Cloud accounting refers to how cloud usage is recorded and charged. We identified four federated cloud platforms which do not include an accounting system. This work presents an accounting mechanism implemented for one of these platforms focused on IaaS. Further, we analyse our proposal in a qualitative fashion.
Use of qigong therapy in the detoxification of heroin addicts. (2002)

Results suggest that qigong may be an effective alternative for heroin detoxification without side effects, though we cannot completely eliminate the possibility of the placebo effect from the current study.
A channel demodulator IC for digital audio broadcasting (2002)

This paper describes the design of a channel demodulator IC for a Digital Audio Broadcasting (DAB) system. The IC contains 466K-transistors and includes a 160 K embedded Dynamic RAM. The design was done using the PIRAMID silicon compiler. Using the compiler it was possible to create on short term an application specific complex-arithmetic signal processor. The IC, which allows for the first time real-time OFDM demodulation, is being used in current prototypes of a DAB receiver.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
USE OF EUCALYPTUS WOOD FOR ORIENTED STRAND BOARD (OSB MANUFACTURING (2004)

This research evaluated the potential use of Eucalyptus species for OSB manufacturing. The boards were manufactured at the density of 0,70 g/cm³ and 6% of the phenol-formaldheyde resin contents. The following Eucalyptus species were studied: E. grandis E. dunnii ,E. tereticornis E. saligna ,E. citriodora, and E. maculata. The results of the physical and mechanical property tests showed high potentiality of the uses of Eucalyptus grandis and Eucalyptus saligna for OSB manufacturing, Boards manufactured with Eucalyptus grandis wood presented similar or higher average values for physical and mechanical properties, in comparison to Pinus taeda, which is the main species used for OSB production in Brazil.
Fatal ball-valve airway obstruction by an extensive blood clot during mechanical ventilation (1996)

A ball-valve airway obstruction by a blood clot cast of almost the whole bronchial tree occurred in a small-cell lung cancer patient, who had been on mechanical ventilation for 9 days. Chest radiographs revealed overinflated lungs. Attempts to remove the cast via fibreoptic bronchoscopy were unsuccessful and the patient died. A postmortem extraction of the clot was performed with a rigid tube. This case is rare because of absence of severe haemoptysis and lung volume reduction.
API2-MALT1 oncoprotein promotes lymphomagenesis<i>via</i>unique program of substrate ubiquitination and proteolysis (2016)

Lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is the most common extranodal B cell tumor and accounts for 8% of non-Hodgkin's lymphomas. Gastric MALT lymphoma is the best-studied example and is a prototypical neoplasm that occurs in the setting of chronic inflammation brought on by persistent infection or autoimmune disease. Cytogenetic abnormalities are commonly acquired during the course of disease and the most common is chromosomal translocation t(11;18)(q21;q21), which creates the API2-MALT1 fusion oncoprotein. t(11;18)-positive lymphomas can be clinically aggressive and have a higher rate of dissemination than t(11;18)-negative tumors. Many cancers, including MALT lymphomas, characteristically exhibit deregulated over-activation of cellular survival pathways, such as the nuclear factor-κB (NF-κB) pathway. Molecular characterization of API2-MALT1 has revealed it to be a potent activator of NF-κB, which is required for API2-MALT1-induced cellular transformation, however the mechanisms by which API2-MALT1 exerts these effects are only recently becoming apparent. The API2 moiety of the fusion binds tumor necrosis factor (TNF) receptor associated factor (TRAF) 2 and receptor interacting protein 1 (RIP1), two proteins essential for TNF receptor-induced NF-κB activation. By effectively mimicking ligand-bound TNF receptor, API2-MALT1 promotes TRAF2-dependent ubiquitination of RIP1, which then acts as a scaffold for nucleating and activating the canonical NF-κB machinery. Activation occurs, in part, through MALT1 moiety-dependent recruitment of TRAF6, which can directly modify NF-κB essential modulator, the principal downstream regulator of NF-κB. While the intrinsic MALT1 protease catalytic activity is dispensable for this canonical NF-κB signaling, it is critical for non-canonical NF-κB activation. In this regard, API2-MALT1 recognizes NF-κB inducing kinase (NIK), the essential upstream regulator of non-canonical NF-κB, and cleaves it to generate a stable, constitutively active fragment. Thus, API2-MALT1 harnesses multiple unique pathways to achieve deregulated NF-κB activation. Emerging data from our group and others have also detailed additional gain-of-function activities of API2-MALT1 that extend beyond NF-κB activation. Specifically, API2-MALT1 recruits and subverts multiple other signaling factors, including LIM domain and actin-binding protein 1 (LIMA1) and Smac/DIABLO. Like NIK, LIMA1 represents a unique substrate for API2-MALT1 protease activity, but unlike NIK, its cleavage sets in motion a major NF-κB-independent pathway for promoting oncogenesis. In this review, we highlight the most recent results characterizing these unique and diverse gain-of-function activities of API2-MALT1 and how they contribute to lymphomagenesis.
Neuroprotective Effect of the AMPA Receptor Antagonist LY-293558 in Focal Cerebral Ischemia in the Cat (1994)

The effects of the glutamate alpha-amino-3-hydroxy 5-methyl-4-isoxazole propionate (AMPA) receptor antagonist LY-293558 in reducing ischemic brain damage have been assessed in halothane-anesthetized cats. Focal cerebral ischemia was produced by permanent occlusion of one middle cerebral artery, and the animals were killed 6 h later. The amount of early irreversible ischemic damage was assessed at 16 predetermined stereotactic planes by an observer blinded to treatment paradigm employed. Treatment with LY-293558 (15 mg/kg i.v., plus infusion of 7 mg/kg/h) initiated 30 min prior to middle cerebral artery occlusion reduced significantly (p < 0.02) the volume of ischemic damage (from 3,423 +/- 212 mm3 of the cerebral hemisphere in vehicle-treated cats to 2,822 +/- 569 mm3 in LY-293558-treated cats). The present data demonstrate that an AMPA receptor antagonist can reduce focal ischemic damage in a gyrencephalic species in which key physiological variables have been controlled and monitored throughout the postischemic period. These data provide additional support for the clinical evaluation of AMPA receptor antagonists in focal cerebral ischemia in humans.
Requirements on channel probes for automatic channel selection (1996)

Whilst strategies can be developed to maintain high data rate communications under benign conditions, the same waveforms are inappropriate when the channel quality is low. It seems likely, therefore, that many future HF point to point communicators will have a number of waveforms at their disposal. These will range from the high capacity variety which operate over the benign channel to relatively low capacity schemes which operate well over the disturbed channel. It is one of the purposes of ARCS (automatic radio control system) to make that selection between waveforms; the aim is clearly to maintain a high data rate whilst also keeping the bit error rate to an acceptably low value. In order to fulfil the above role an ARCS probe must be designed to measure the full range of conditions which may occur. Furthermore, the probe must be able to use those measurements appropriately to select from amongst the available waveforms. Strategies for accomplishing this are the subject of active research and include considerations such as probe duration, S/(N+I) evaluation, determination of multipath, Doppler shifts and spreads, the impact of bimodal Doppler spectra and the time rate of change of the aforementioned parameters. This paper does not attempt to cover all of these factors but restricts itself to illustrating the range of Doppler shifts and spreads which can be experienced on difficult high latitude HF channels. These channels represent extremes in Doppler related distortion.
MEMBRANE AND PROTOPLASM RESISTANCE IN THE SQUID GIANT AXON (1939)

The direct current longitudinal resistance of the squid giant axon was measured as a function of the electrode separation. Large sea water electrodes were used and the inter-electrode length was immersed in oil. The slope of the resistance vs. separation curve is large for a small electrode separation, but becomes smaller and finally constant as the separation is increased. An analysis of the resistance vs. length curves gives the following results. The nerve membrane has a resistance of about 1000 ohm cm.(2) The protoplasm has a specific resistance of about 1.4 times that of sea water. The resistance of the connective tissue sheath outside the fiber corresponds to a layer of sea water about 20micro in thickness. The characteristic length for the axon is about 2.3 mm. in oil and 6.0 mm. in sea water.
On-line laser detection of gases (1982)

An IR laser system for detection of toxic and combustible gases has been developed for petrochemical plants and offshore platforms. The scanning range of the beam, which can be up to 1 km in length, permits a complete complex to be covered with a single instrument. Another application uses the instrument mounted on an aircraft flying along a pipeline searching for gas leaks.
Micellar Size Effect in Emulsion Polymerization (1976)

One of the methods for preparing monodispersed latices, i.e. latices of uniform particle size distribution, is to use mixed surfactants as the emulsifier in the emulsion polymerization process. The term mixed surfactants, in general, refers to mixtures of ionic and nonionic surfactants. Besides giving latices of narrow particle size distribution, mixed surfactant systems have shown several other interesting characteristics which lighten some aspects concerning the mechanism of particle nucleation in emulsion polymerization process. Woods, Dodge, Krieger, and Piece (1) obtained monodispersed polystyrene latices at about 50 percent conversion from a series of polymerization recipes with mixed surfactants of different ionic to nonionic ratios. They found that the size of the polystyrene particles in these latices decreased with increasing amount of the ionic component in the surfactant mixtures. To interpret their observations, they adopted the theory of mixed micelle formation by mixed surfactant in aqueous solutions. This concept had been previously
Applications of scattering-type scanning near-field optical microscopy in the infrared (2013)

This thesis is split into two broad sections. These are defined by the various applications of scattering-type near-field optical microscopy (s-SNOM) in different parts of the electromagnetic spectrum; the near-infrared (700 - 1000nm) and the mid-infrared (6 - 10um). S-SNOM is a means of imaging surfaces at resolutions well below the diffraction limit - the level of recorded detail does not depend on the wavelength of light (as it does with traditional optical microscopy), but instead on the sharpness of a probe (usually around 10nm), meaning an image resolution approaching a thousandth of a wavelength in the mid-infrared. For the work presented in the near-infrared, the focus lies with the modelling and mapping of various plasmonic resonances supported by metallic nanostructures. These resonances have the ability to "squeeze" light into substantially sub-wavelength volumes which is useful for a variety of applications ranging from cancer treatments to molecular sensing. The mid-infrared section starts with the implementation of a pulsed quantum cascade laser (QCL) as the system's light source. This presents some instrumentation challenges as all s-SNOM imaging to date has been conducted with continuous-wave (CW) lasers. Using a pulsed laser also raises some significant signal-to-noise implications which are quantified and discussed. In terms of the experimental applications of such a setup, the first steps towards ultra-high resolution infrared chemical spectroscopy are made by studying the epithelial cells of an oesophageal biopsy. The thesis concludes with an examination of the major noise sources faced by s-SNOM, and makes a number of recommendations on how their effects can be mitigated.
Concise Review: The Use of Adipose-Derived Stromal Vascular Fraction Cells and Platelet Rich Plasma in Regenerative Plastic Surgery (2016)

Tissue engineering has emerged at the intersection of numerous disciplines to meet a global clinical need for technologies to promote the regeneration of tissues. Recently, many authors have focused their attention on mesenchymal stem/stromal cells (MSCs) for their capacity to differentiate into many cell lineages. The most widely studied cell types are bone marrow mesenchymal stem cells and adipose-derived stem cells (ASCs), which display similar results. Biomaterials, cells, and growth factors are needed to design a regenerative plastic surgery approach in the treatment of organ and tissue defects, but not all tissues are created equal. The aim of this article is to describe the advances in tissue engineering through the use of ASCs, platelet rich plasma, and biomaterials to enable regeneration of damaged complex tissue. Stem Cells 2017;35:117-134.
On-chip frequency comb generation at visible wavelengths via simultaneous second- and third-order optical nonlinearities (2014)

Microresonator-based frequency comb generation at or near visible wavelengths would enable applications in precise optical clocks, frequency metrology, and biomedical imaging. Comb generation in the visible has been limited by strong material dispersion and loss at short wavelengths, and only very narrowband comb generation has reached below 800 nm. We use the second-order optical nonlinearity in an integrated high-Q silicon nitride ring resonator cavity to convert a near-infrared frequency comb into the visible range. We simultaneously demonstrate parametric frequency comb generation in the near-infrared, second-harmonic generation, and sum-frequency generation. We measure 17 comb lines converted to visible wavelengths extending to 765 nm.