gebhart/patrepeval huggingface dataset:
Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21(WAF1/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2. (1999)

Epidemiological studies have shown that the regular consumption of red wine may in part account for the apparent compatibility of a high fat diet with a low incidence of coronary atherosclerosis. This phenomenon, commonly referred to as the French paradox, may be associated with red wine constituents that exhibit tumor-preventive properties as well as inhibit reactions that increase the risk of coronary heart disease. Here we show that resveratrol, a polyphenol in red wine, induces nitric oxide synthase, the enzyme responsible for the biosynthesis of NO, in cultured pulmonary artery endothelial cells, suggesting that resveratrol could afford cardioprotection by affecting the expression of nitric oxide synthase. We also show that resveratrol inhibits the proliferation of pulmonary artery endothelial cells, which, based on flow cytometric analysis, correlates with the suppression of cell progression through S and G2 phases of the cell cycle. Western blot analysis and immunocytochemical protein detection combined with multiparameter flow cytometry further demonstrate that the perturbed progression through S and G2 phases is accompanied by an increase in the expression of tumor suppressor gene protein p53 and elevation of the level of cyclin-dependent kinase inhibitor p21(WAF1/CIP1). All of the observed effects of resveratrol, including induction of apoptosis at its higher concentration, are also compatible with its putative chemopreventive and/or antitumor activity.
Synthesis of Oxazoline-2-thiols from 2-Aminoalcohols<sup>1</sup> (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Oxazoline-2-thiols from 2-Aminoalcohols1A. A. RosenCite this: J. Am. Chem. Soc. 1952, 74, 12, 2994–2997Publication Date (Print):June 1, 1952Publication History Published online1 May 2002Published inissue 1 June 1952https://pubs.acs.org/doi/10.1021/ja01132a011https://doi.org/10.1021/ja01132a011research-articleACS PublicationsRequest reuse permissionsArticle Views375Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-performance III-V MOSFET with nano-stacked high-k gate dielectric and 3D fin-shaped structure (2012)

A three-dimensional (3D) fin-shaped field-effect transistor structure based on III-V metal-oxide-semiconductor field-effect transistor (MOSFET) fabrication has been demonstrated using a submicron GaAs fin as the high-mobility channel. The fin-shaped channel has a thickness-to-width ratio (TFin/WFin) equal to 1. The nano-stacked high-k Al2O3 dielectric was adopted as a gate insulator in forming a metal-oxide-semiconductor structure to suppress gate leakage. The 3D III-V MOSFET exhibits outstanding gate controllability and shows a high Ion/Ioff ratio > 105 and a low subthreshold swing of 80 mV/decade. Compared to a conventional Schottky gate metal-semiconductor field-effect transistor or planar III-V MOSFETs, the III-V MOSFET in this work exhibits a significant performance improvement and is promising for future development of high-performance n-channel devices based on III-V materials.
Evanescent-wave holography by use of surface-plasmon resonance (1997)

We report a method for evanescent-wave holography using surface-plasmon resonance from the illumination light. The device we have made consists of three layers: a prism of high refractive index, a thin metallic film, and a grating. Evanescent waves generated by the surface plasmons are diffracted with a prerecorded grating to reconstruct a three-dimensional image. The possibility of white-light illumination and the application to a flat display system with waveguides in the proposed method are discussed.
The magnetohydrodynamic squeeze film (1964)

Magnetohydrodynamic squeeze films are investigated theoretically and experimentally. The theory of magnetohydrodynamic lubrication as applied to squeeze films is extended to include fluid-inertia effects and buoyant forces. Excellent agreement is obtained between theory and experiment.
Statistical copolymers of norbornene and 5-vinyl-2-norbornene by a ditungsten complex mediated ring-opening metathesis Polymerization: Synthesis, thermal properties, and kinetics of thermal decomposition (2013)

Statistical copolymers of norbornene (NBE) with 5-vinyl-2-norbornene (VNBE) were prepared by ring-opening metathesis polymerization, employing the triply bonded ditungsten complex Na[W2(μ-Cl)3Cl4(THF)2].(THF)3. NMR measurements revealed that the side vinyl groups of the VNBE monomer remain intact during the copolymerization reaction. The reactivity ratios were estimated using the Finemann–Ross (FR), the inverted FR, and the Kelen–Tüdos graphical methods. Structural parameters of the copolymers were obtained by calculating the dyad sequence fractions, which were derived using the monomer reactivity ratios. The glass transition temperatures, Tg, of the copolymers were measured by differential scanning calorimetry measurements and were examined in the frame of several theoretical equations allowing the prediction of these Tg values. The best fit was obtained using methods that take into account the monomer sequence distribution of the copolymers. Finally, the kinetics of the thermal decomposition of the copolymers was studied by thermogravimetric analysis in the frame of the Ozawa–Flynn–Wall and Kissinger methods. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 4835–4844
Sub-O(log n) Out-of-Order Sliding-Window Aggregation (2018)

Sliding-window aggregation summarizes the most recent information in a data stream. Users specify how that summary is computed, usually as an associative binary operator because this is the most general known form for which it is possible to avoid naively scanning every window. For strictly in-order arrivals, there are algorithms with $O(1)$ time per window change assuming associative operators. Meanwhile, it is common in practice for streams to have data arriving slightly out of order, for instance, due to clock drifts or communication delays. Unfortunately, for out-of-order streams, one has to resort to latency-prone buffering or pay $O(\log n)$ time per insert or evict, where $n$ is the window size. This paper presents the design, analysis, and implementation of FiBA, a novel sliding-window aggregation algorithm with an amortized upper bound of $O(\log d)$ time per insert or evict, where $d$ is the distance of the inserted or evicted value to the closer end of the window. This means $O(1)$ time for in-order arrivals and nearly $O(1)$ time for slightly out-of-order arrivals, with a smooth transition towards $O(\log n)$ as $d$ approaches $n$. We also prove a matching lower bound on running time, showing optimality. Our algorithm is as general as the prior state-of-the-art: it requires associativity, but not invertibility nor commutativity. At the heart of the algorithm is a careful combination of finger-searching techniques, lazy rebalancing, and position-aware partial aggregates. We further show how to answer range queries that aggregate subwindows for window sharing. Finally, our experimental evaluation shows that FiBA performs well in practice and supports the theoretical findings.
Differential response of weed and crop species to potassium and sulphur fertilizers (2007)

Fertilization may affect the relative competitive ability of weeds and crops if the growth response to fertilizer differs among species. Greenhouse studies were conducted to evaluate the relative biomass yield response of 19 weed species and the crops canola (Brassica napus L.) and spring wheat (Triticum aestivum L.) to potassium (K) and sulphur (S) fertilization. Seven weed species showed a significant increase in biomass production at 6 wk with K fertilization, but biomass production of canola and wheat did not increase with K addition. Sulphur fertilizer increased the biomass production of canola, flixweed (Descurainia sophia L.) and wild mustard (Sinapis arvensis L.), three of the four Cruciferae species evaluated, as well as that of hairy nightshade (Solanum sarrachoides Sendtner), round-leaved mallow (Malva pusilla Sm.) and stork’s-bill [Erodium cirutarium (L.) L’Her. Ex. Ait.]. Sulphur fertilizer did not increase the biomass production of spring wheat or of any grass weed species. The data from the greenhouse study support the concept that fertilization may shift the relative competition between a crop and the weed population if the weeds are more responsive than the crop to the type of fertilizer applied. However, this concept should be tested under field conditions. Key words: Integrated weed management, sulphur, potassium
Human immunodeficiency virus reverse transcriptase and protease sequence database (2003)

The HIV reverse transcriptase and protease sequence database is an on-line relational database that catalogues evolutionary and drug-related sequence variation in the human immunodeficiency virus (HIV) reverse transcriptase (RT) and protease enzymes, the molecular targets of antiretroviral therapy (http://hivdb.stanford.edu). The database contains a compilation of nearly all published HIV RT and protease sequences, including submissions to GenBank, sequences published in journal articles and sequences of HIV isolates from persons participating in clinical trials. Sequences are linked to data about the source of the sequence, the antiretroviral drug treatment history of the person from whom the sequence was obtained and the results of in vitro drug susceptibility testing. Sequence data on two new molecular targets of HIV drug therapy-gp41 (cell fusion) and integrasewill be added to the database in 2003.
低双折射包层模下陷光敏光纤 (2010)

The highly Ge-doped photosensitive fiber (PSF) has been widely used in the fabrication of fiber Bragg gratings (FBGs). Its birefringence and cladding mode coupling characteristics greatly influence FBG's transmission feature in communication application areas. In this work, a new concept of the PSF is introduced which, along with an optimized birefringence design, a precisely controlled fabrication process, and a cladding mode depressed design, results in a written FBG with -25-dB clad mode-depressed ratio and a polarization mode dispersion value less than 0.045 ps.
Use of Dpn I Restriction Enzyme to Assess Newly Replicated Gene Copies in Amplifiable Vector Systems (2003)

Bacterially propagated plasmid DNA can be transfected into established eukaryotic cell lines or primary cell cultures by a variety of techniques, such as electroporation (see Chapter 5 , this vol) (1), scrape-loading (2), and DEAE dextran (see Chapter 3 ) or calcium phosphate mediated gene transfer (see Chapter 2 ) (3-5). At least some of the DNA introduced into the cells enters into the nucleus, where it is thought to be assembled into chromatin (6), and is maintained extrachromosomally for at least 48 h. During this time, the cellular chromosomal DNA may have undergone one or more rounds of DNA replication. However, the extrachromosomal transfected DNA will not replicate unless the DNA sequences contained in the plasmid include a DNA origin of replication recognized by the host cell. Origin sequences have so far proved difficult to identify in eukaryotic chromosomes. In contrast, viral genomes, such as SV40 and polyoma, have well-characterized origins of replication (7), which, when included on DNA.
Metabolism of carbovir, a potent inhibitor of human immunodeficiency virus type 1, and its effects on cellular metabolism (1993)

Carbovir (CBV) [the (--)-enantiomer of the carbocyclic analog of 2',3'-dideoxy-2',3'-didehydroguanosine] is a potent inhibitor of human immunodeficiency virus type 1 (HIV) replication in vitro. We have characterized the metabolism of CBV and its effect on cellular metabolism in an effort to better understand its mechanism of action. CBV was primarily metabolized to the 5'-triphosphate of CBV (CBV-TP) to concentrations sufficient to inhibit HIV reverse transcriptase. Infection of CEM cells with HIV did not affect the metabolism of CBV. In CEM cells, there was no evidence of the degradation of CBV by purine nucleoside phosphorylase. The half-life of CBV-TP in CEM cells was 2.5 h, similar to that of the 5'-triphosphate of zidovudine (AZT). However, unlike the levels of the 5'-triphosphate of AZT, CBV-TP levels declined without evidence of a plateau. CBV did not affect the metabolism of AZT, and AZT did not affect the metabolism of CBV. A small amount of CBV was incorporated into DNA in intact CEM cells, and this incorporation was increased by incubation with mycophenolic acid, an inhibitor of IMP dehydrogenase. CBV specifically inhibited the incorporation of nucleic acid precursors into DNA but had no effect on the incorporation of radiolabeled precursors into RNA or protein. CBV did not decrease the level of TTP, dGTP, dCTP, or dATP. These results suggested that the cytotoxicity of CBV was due to the inhibition of DNA synthesis. Further studies are necessary to identify the target(s) responsible for growth inhibition.
ایمن سازی فعال گاوها با واکسنهای کشته تهیه شده از ویروس کشت سلولی طاعون گاوی (1975)

Cell cultured rinderpest virus inactivated by treatment with 0·01% merthiolate or 0·013% formaldehyde or by exposure to ultraviolet light induced the production of transient neutralizing antibodies in cattle. The addition of aluminium hydroxide or incomplete Freund’s adjuvant significantly enhanced neutralizing antibody titres whereas the addition of saponin dramatically depressed the titres. The dose of adjuvant inactivated vaccine was critical.
Telomerase (GV1001) vaccination together with gemcitabine in advanced pancreatic cancer patients (2014)

Telomerase is expressed in 85-90 % of pancreatic adenocarcinomas and might be a target for active cancer immunotherapy. A study was conducted to investigate safety and immunogenicity in non-resectable pancreatic carcinoma patients using a 16-amino acid telomerase peptide (GV1001) for vaccination in combination with GM-CSF and gemcitabine as first line treatment. Three different vaccine treatment schedules were used; [A (n=6), B (n=6) and C (n=5)]. Groups A/B received GV1001, GM-CSF and gemcitabine concurrently. Group C received initially GV1001 and GM-CSF while gemcitabine was added at disease progression. Group D (n=4) was treated with gemcitabine alone. Adverse events (AE) related to vaccination were mild (grades I-II). Grade III AEs were few and transient. An induced GV 1001‑specific immune response was defined as an increase ≥2 above the baseline value in one of the assays (DTH, proliferation, ELISPOT and cytokine secretion assays, respectively). A telomerase‑specific immune response was noted in 4/6 patients in group A, 4/6 patients in group B and 2/5 patients in group C. An induced ras‑specific immune response (antigenic spreading) was seen in 5 of the 17 patients. The cytokine pattern was that of a Th1-like profile. A treatment induced telomerase or ras response was also noted in group D. All responses were weak and transient. A significant decrease in regulatory T-cells over time was noted in patients in groups A and B (p<0.05). Telomerase vaccination (GV1001) in combination with chemotherapy appeared to be safe but the immune responses were weak and transient. Measures have to be taken to optimize immune responses of GV1001 for it to be considered of clinical interest.
Surface Texture Formation in Al <sub>2</sub> O <sub>3</sub> Substrates (1975)

Crystallographic texture formed at the surface during the sintering of 3 tape‐cast Al 2 O 3 substrates was studied as a function of sintering temperature and atmosphere. The sintering atmosphere strongly influenced the surface texture formed. A strong (001) basal‐plane fiber texture normal to the plane of the substrate is produced when commercial green substrates are sintered in air at 1600° to 1700°C; sintering in vacuum (< 2 × 10 ‐6 mm Hg) or dry H 2 produces a weaker texture. Grain growth is a necessary but insufficient condition for the formation of a strong surface texture. It is proposed that surface texture formation is caused by an excess driving force which results in growth of grains with a low‐surface‐energy plane exposed at the substrate surface. Since the surface energy of a crystallographic plane is a function of atmosphere and impurities adsorbed on the surface, both these factors should have a pronounced effect on surface texture formation, as observed in the present study.
<i>DDX3Y</i>, a Male-Specific Region of Y Chromosome Gene, May Modulate Neuronal Differentiation (2015)

Although it is apparent that chromosome complement mediates sexually dimorphic expression patterns of some proteins that lead to functional differences, there has been insufficient evidence following the manipulation of the male-specific region of the Y chromosome (MSY) gene expression during neural development. In this study, we profiled the expression of 23 MSY genes and 15 of their X-linked homologues during neural cell differentiation of NTERA-2 human embryonal carcinoma cell line (NT2) cells in three different developmental stages using qRT-PCR, Western blotting, and immunofluorescence. The expression level of 12 Y-linked genes significantly increased over neural differentiation, including RBMY1, EIF1AY, DDX3Y, HSFY1, BPY2, PCDH11Y, UTY, RPS4Y1, USP9Y, SRY, PRY, and ZFY. We showed that siRNA-mediated knockdown of DDX3Y, a DEAD box RNA helicase enzyme, in neural progenitor cells impaired cell cycle progression and increased apoptosis, consequently interrupting differentiation. Label-free quantitative shotgun proteomics based on a spectral counting approach was then used to characterize the proteomic profile of the cells after DDX3Y knockdown. Among 917 reproducibly identified proteins detected, 71 proteins were differentially expressed following DDX3Y siRNA treatment compared with mock treated cells. Functional grouping indicated that these proteins were involved in cell cycle, RNA splicing, and apoptosis, among other biological functions. Our results suggest that MSY genes may play an important role in neural differentiation and demonstrate that DDX3Y could play a multifunctional role in neural cell development, probably in a sexually dimorphic manner.
Pharmaceutical container/closure integrity. I: Mass spectrometry-based helium leak rate detection for rubber-stoppered glass vials. (1997)

The development of mass spectrometry-based leak detection for pharmaceutical container integrity was undertaken to provide an alternative to microbial challenge testing. Standard 10-mL vials were modified to contain pinholes (0.5 to 10 microns) by affixing micropipettes with epoxy into 2-mm vial side wall holes. The absolute leak rate was determined using vials that were sealed in a tracer (helium) environment with butyl rubber stoppers and crimps. Alternatively leak rates were determined using vials that were sealed in room air and exposed to tracer under pressure (charging or bombing). Tracer leak rates were measured with mass spectrometry leak rate detectors. The absolute leak rate was correlated the squared nominal leak radius which suggested that the mode of gas flow through the glass pipette leaks was more turbulent than viscous even at low leak rates typically associated with viscous flow. The minimum observed absolute leak rate was about 10(-6.6) std cc/sec and was likely due to helium permeation through the rubber stoppers. Heat-stressed rubber stoppers did not affect the baseline absolute leak rate. Adsorption of helium tracer to the test unit surfaces was found to confound baseline leak rate measurement reliability but was eliminated as a source of variation by exposing the test units to ambient air for > or = 12 hours. The absolute leak rate and the leak rate measured after charging were related in a mathematically predictable way.
On the output spectrum of unlocked driven oscillators (1969)

A method is given to determine the components of the signal of an unlocked driven oscillator. The phase modulation signal, which perturbs the free oscillation, is expanded in a Fourier series.
The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis (2002)

These data imply the involvement of MMP3 in chronic remodelling after conventional balloon angioplasty, and suggest that the 6A6A MMP3 genotype is a genetic susceptibility factor for restenosis after angioplasty without stenting.
New nonlinear optical chromophores exhibiting good transparency and large nonlinearity: synthesis and characterization of chromophores with stilbene and ring-locked triene as a combined conjugation bridge (2002)

Two new chromophores employing the combination of stilbene and ring-locked triene as their conjugation bridge were synthesized and found to display blue-shifted absorption and large optical nonlinearity compared with their stilbene-only, triene-only and azobenzene analogues. The two new chromophores with the combined conjugation bridge provide better optimization of the nonlinearity–transparency trade-off.
Preparation of (p-phenylene)bis(aryliodonium) ditriflates and their double substitution by some nucleophiles (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of (p-phenylene)bis(aryliodonium) ditriflates and their double substitution by some nucleophilesTsugio Kitamura, Ryuji Furuki, Kensuke Nagata, Hiroshi Taniguchi, and Peter J. StangCite this: J. Org. Chem. 1992, 57, 25, 6810–6814Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/jo00051a025https://doi.org/10.1021/jo00051a025research-articleACS PublicationsRequest reuse permissionsArticle Views777Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts