gebhart/patrepeval huggingface dataset:
Tissue oxygen monitoring in rodent models of shock (2007)

Tissue Po(2) (tPo(2)) reflects the balance between local O(2) supply and demand and, thus, could be a useful monitoring modality. However, the consistency and amplitude of the tPo(2) response in different organs during different cardiorespiratory insults is unknown. Therefore, we investigated the effects of endotoxemia, hemorrhage, and hypoxemia on tPo(2) measured in deep and peripheral organ beds. We compared arterial pressure, blood gas and lactate levels, descending aortic and renal blood flow, and tPo(2) in skeletal muscle, bladder epithelium, liver, and renal cortex during 1) LPS infusion (10 mg/kg), 2) sequential removal of 10% of circulating blood volume, and 3) reductions in inspired O(2) concentration in an anesthetized Wistar rat model with values measured in sham-operated animals. Different patterns were seen in each of the shock states, with condition-specific variations in the degree of acidemia, lactatemia, and tissue O(2) responses between organs. Endotoxemia resulted in a rise in bladder tPo(2) and an early fall in liver tPo(2) but no significant change in muscle and renal cortical tPo(2). Progressive hemorrhage, however, produced proportional declines in liver, muscle, and bladder tPo(2), but renal cortical tPo(2) was maintained until profound blood loss had occurred. By contrast, progressive hypoxemia resulted in proportional decreases in tPo(2) in all organ beds. This study highlights the heterogeneity of responses in different organ beds during different shock states that are likely related to local changes in O(2) supply and utilization. Whole body monitoring is not generally reflective of these changes.
A radical spin on viologen polymers: organic spin crossover materials in water (2014)

A polymer containing viologen radical cation monomer units is shown to reversibly switch between paramagnetic and diamagnetic states via non-covalent host-guest interactions or temperature control in water. Cycling between diamagnetic and paramagnetic forms is accompanied by changes in optical and magnetic properties.
Large-scale comparison of protein sequence alignment algorithms with structure alignments (2000)

Sequence alignment programs such as BLAST and PSI-BLAST are used routinely in pairwise, profile-based, or intermediate-sequence-search (ISS) methods to detect remote homologies for the purposes of fold assignment and comparative modeling. Yet, the sequence alignment quality of these methods at low sequence identity is not known. We have used the CE structure alignment program (Shindyalov and Bourne, Prot Eng 1998;11:739) to derive sequence alignments for all superfamily and family-level related proteins in the SCOP domain database. CE aligns structures and their sequences based on distances within each protein, rather than on interprotein distances. We compared BLAST, PSI-BLAST, CLUSTALW, and ISS alignments with the CE structural alignments. We found that global alignments with CLUSTALW were very poor at low sequence identity (<25%), as judged by the CE alignments. We used PSI-BLAST to search the nonredundant sequence database (nr) with every sequence in SCOP using up to four iterations. The resulting matrix was used to search a database of SCOP sequences. PSI-BLAST is only slightly better than BLAST in alignment accuracy on a per-residue basis, but PSI-BLAST matrix alignments are much longer than BLAST's, and so align correctly a larger fraction of the total number of aligned residues in the structure alignments. Any two SCOP sequences in the same superfamily that shared a hit or hits in the nr PSI-BLAST searches were identified as linked by the shared intermediate sequence. We examined the quality of the longest SCOP-query/ SCOP-hit alignment via an intermediate sequence, and found that ISS produced longer alignments than PSI-BLAST searches alone, of nearly comparable per-residue quality. At 10-15% sequence identity, BLAST correctly aligns 28%, PSI-BLAST 40%, and ISS 46% of residues according to the structure alignments. We also compared CE structure alignments with FSSP structure alignments generated by the DALI program. In contrast to the sequence methods, CE and structure alignments from the FSSP database identically align 75% of residue pairs at the 10-15% level of sequence identity, indicating that there is substantial room for improvement in these sequence alignment methods. BLAST produced alignments for 8% of the 10,665 nonimmunoglobulin SCOP superfamily sequence pairs (nearly all <25% sequence identity), PSI-BLAST matched 17% and the double-PSI-BLAST ISS method aligned 38% with E-values <10.0. The results indicate that intermediate sequences may be useful not only in fold assignment but also in achieving more complete sequence alignments for comparative modeling.
[Frequency and distribution of oral lesions in elderly patients]. (1991)

In this study the relative frequency of oral lesions was evaluated in a group of 526 patients, 55 years old or elder. Clinical and pathological data were obtained from 244 patients who attended to a clinic of Medical and Social Assistance Program (PAMI) ad from 282 cases registered in the files of the Surgical Pathology Laboratory F.O.U.B.A. (LAP) since 1984 to 1986. The mean age of the groups was 63 years old. The most frequency lesions were the pseudotumors (44.6%) in LAP and (17.2%) in PAMI; premalignant lesions were (20.5%) in LAP, while in PAMI (2.4%). The cysts in LAP found (15.6%) in PAMI were (2.4%). The groups of PAMI showed (90%) of Candidiasis. Traumatic ulcer (30.7%) and afthae (28.8%). In LAP were (4.6%) the traumatic ulcer. The malignant tumors the most frequency was carcinoma espinocelular (8.16%) LAP and (6.56%) PAMI. It was remarkable that stomatodine as represented in PAMI (72.2%) and Candidiasis were (90%). Candidiasis were 90% of the specific inflammations. Results suggest that oral mobility in elderly patients correlates with the findings in this type of social assisted groups. The figures of the importance of methodical collaboration of Stomatologists and Oral Pathologists for differential diagnosis.
Development of  -Type Energy Filtering TEM (1996)

A new energy-filter is developed to improve image resolution and enhance the contrast of transmission electron microscopic (TEM) images. The filter consists of two sector magnetic fields and is built into a TEM column. Electrons travel through the filter following γ-shape trajectories. Electrons in a specific range of energies are selected and focused to produce an image. The energy filter was incorporated into a TEM for observation of unstained biological specimens. With a 1-μm thick specimen, zero-loss electrons produce a sharper, or less chromatic-aberration image compared with that of a conventional TEM. Meanwhile, with a thin specimen less than 0.1 μm thick, around 250eV-loss electrons produce a sharp image while zero-loss electrons do not. Observations show that a TEM equipped with the energy filter is useful for microscopy of fine structures of biological specimens under natural conditions.
The ExAC browser: displaying reference data information from over 60 000 exomes (2016)

Worldwide, hundreds of thousands of humans have had their genomes or exomes sequenced, and access to the resulting data sets can provide valuable information for variant interpretation and understanding gene function. Here, we present a lightweight, flexible browser framework to display large population datasets of genetic variation. We demonstrate its use for exome sequence data from 60 706 individuals in the Exome Aggregation Consortium (ExAC). The ExAC browser provides gene- and transcript-centric displays of variation, a critical view for clinical applications. Additionally, we provide a variant display, which includes population frequency and functional annotation data as well as short read support for the called variant. This browser is open-source, freely available at http://exac.broadinstitute.org, and has already been used extensively by clinical laboratories worldwide.
Kinetic Patterns During Stair Ascent in Patients with Transtibial Amputations Using Three Different Prostheses (1999)

Published quarterly by the AAOP, JPO: Journal of Prosthetics and Orthotics provides information on new devices, fitting and fabrication techniques, and patient management experiences. The focus is on prosthetics and orthotics, with timely reports from related fields such as orthopaedic research, occupational therapy, physical therapy, orthopaedic surgery, amputation surgery, physical medicine, biomedical engineering, psychology, ethics, and gait analysis. Each issue contains research-based articles reviewed and approved by a highly qualified editorial board, and two Academy self-study quizzes offering a total of two CEUs.
New Analytical Techniques for CO2 Capture Solvents (2006)

The densities and refractive indices of two binary systems (water + MEA and water + MDEA) and three ternary systems (water + MEA + CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , water + MDEA + CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and water + MEA + MDEA) used for carbon dioxide (CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) capture were measured over the range of compositions of the aqueous alkanolamine(s) used for CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> absorption at temperatures from 295 to 338 K. Experimental densities were modeled empirically while the experimental refractive indices were modeled using well- established models from knowledge of their pure component densities and refractive indices. The density and Gladstone-Dale refractive index models were then used to obtain the compositions of unknown samples of the binary and ternary systems by simultaneous solution of the density and refractive index equations. The results from this technique have been compared with HPLC (high performance liquid chromatography) results, while a third independent technique (acid-base titration) was used to verify the results. The results show that the systems' compositions obtained from the simple and easy to use refractive index/density technique were very comparable to the expensive and laborious HPLC/titration techniques, implying that the refractive index/density technique can be used to replace existing methods for analysis of fresh or non degraded, CO2 loaded, single and mixed alkanolamine solutions.
Prevalence of antimicrobial resistance in intestinal flora of patients undergoing prostatic biopsy: implications for prophylaxis and treatment of infections after biopsy (2010)

Our study shows that in the coliforms in the bowel flora of our local population there is a relatively high level of resistance to ciprofloxacin and coamoxiclav, and very low level of resistance to amikacin. As there was a strong correlation between the antimicrobial sensitivity of organisms causing infections after TGB and those isolated from the rectal swabs, we conclude that rectal swab cultures before TGB provide useful evidence for selecting appropriate antimicrobials for prophylaxis and treatment of TGB-associated infections.
Stress-optic modulator in TriPleX platform using a piezoelectric lead zirconate titanate (PZT) thin film (2015)

We will demonstrate a stress-optic phase modulator in the passive SiN-based TriPleX platform using a layer of piezoelectric material. Regarding the stress-optic effect, the piezoelectric layer deposited on top of an optical waveguide is employed to control the phase of propagating light in the structure by applying an electrical field across the layer. In this work, it is demonstrated that the stress-optic effect lowers the power consumption by a factor of one million for quasi-DC operation and increases the modulation speed by three orders of magnitude, compared to currently used thermo-optic modulation in the TriPleX platform.
EXPRESSION OF CONCERN: Functional p53 determines docetaxel sensitivity in prostate cancer cells (2012)

These results demonstrate that docetaxel induces p53 phosphorylation and that p53 status is a crucial determinant of docetaxel sensitivity in prostate cancer cells.
A note on H. G. Clarke productions (1944)

A note on H. G. Clarke productions Get access Charles D. Williams Charles D. Williams Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 186, Issue 1, 1 January 1944, Pages 19–20, https://doi.org/10.1093/nq/186.1.19 Published: 01 January 1944
Cationic Polymerization of Epoxide by Fluorenylphosphonium Salts as Thermally Latent Initiators. Substituent Effect on the Initiator Activity (2001)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTCationic Polymerization of Epoxide by Fluorenylphosphonium Salts as Thermally Latent Initiators. Substituent Effect on the Initiator ActivityTatsuya Toneri, Fumio Sanda, and Takeshi EndoView Author Information Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan Cite this: Macromolecules 2001, 34, 5, 1518–1521Publication Date (Web):February 2, 2001Publication History Received2 May 2000Revised28 December 2000Published online2 February 2001Published inissue 1 February 2001https://pubs.acs.org/doi/10.1021/ma000759vhttps://doi.org/10.1021/ma000759vbrief-reportACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views776Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cationic polymerization,Cations,Ethers,Polymerization,Salts Get e-Alerts
Tumor Treatment by Direct Electric Current: Computation of Electric Current and Power Density Distribution (1997)

AbstractElectrotherapy by direct electric current was shown to have an anti-tumor effect in different animal tumor models and in clinic. Information on the current density distributions in the tumor, surrounding tissues, and its differences in the different electrode configurations used in our previous studies could be useful in future studies of electrotherapy mechanisms. Therefore, a three-dimensional, anatomically based, finite element model of the mouse with a subcutaneous tumor was built. Different types of electrotherapy, i.e., different electrode configurations, were modeled by applying appropriate boundaq conditions in the grid points. The magnitude of current density in anodic/cathodic electrotherapy is 50 times higher in the middle and 10 times higher on the edge of the tumor when compared to the “field” electrotherapy. The results of the computation show that the effects of the electrotherapy on tumor growth, which were similar in terms of tumor growth delay in all three configurations, are not directly related to the magnitude of the electric current or power density in the tumor.Key Words: ElectrotherapyTumor growthField ModelingFinite element analysis
MCBF: a high-performance scheduling algorithm for buffered crossbar switches (2003)

The buffered crossbar architecture is becoming very attractive for the design of high performance routers due the unique features it offers. Many distributed scheduling algorithms have been proposed for this architecture. Despite their distributed nature, the existing schemes require quite a bit of hardware and timing complexity. We propose a novel scheduling scheme named the most critical buffer first (MCBF). This scheme is based only on the internal buffer information and requires much less hardware than the existing schemes. Yet, it exhibits good performance and outperforms all its competitors. More interestingly, MCBF shows optimal stability performance while being almost a stateless algorithm.
Evaluation of a discrete samples/stopped-flow mixer system for equilibrium and kinetic analyses. (1977)

This paper describes the evaluation of a system for computer-controlled discrete sampling and stopped-flow mixing for equilibrium and kinetic determinations of several sorts of analytes in human serum. The instrumental system features a wash-out sampling system that permits rapid change-over from one sample and (or) reagent type to another, and a mixing-measurement system that can provide reliable data as soon as 10 ms after reagent and sample are mixed. Examples discussed include equilibrium procedures for glucose and cholesterol, slow kinetic procedures for glucose and lactate dehydrogenase, and a fast kinetic method for thiocyanate. The regression equation for all stopped-flow results (n = 114) vs. results by conventional methods is y = (103 +/- 0.01)x - (0.016 +/- 0.019) for numerical values of y between 0.3 and 3.0. The correlation coefficient for these data was 0.991. These results demonstrate that the stopped-flow method is a viable analytical approach for equilibrium, slow kinetic, and fast kinetic determinations that require measurement times shorter than 0.1 s.
Gas-Phase Synthesis of Dimethyl Carbonate from Methanol and Carbon Dioxide Over Co1.5PW12O40 Keggin-Type Heteropolyanion (2010)

The reactivity of Co(1.5)PW(12)O(40) in the direct synthesis of dimethyl carbonate (DMC) from CO(2) and CH(3)OH was investigated. The synthesized catalyst has been characterized by means of FTIR, XRD, TG, and DTA and tested in gas phase under atmospheric pressure. The effects of the reaction temperature, time on stream, and methanol weight hourly space velocity (MWHSV) on the conversion and DMC selectivity were investigated. The highest conversion (7.6%) and highest DMC selectivity (86.5%) were obtained at the lowest temperature used (200 degrees C). Increasing the space velocity MWHSV increased the selectivity of DMC, but decreased the conversion. A gain of 18.4% of DMC selectivity was obtained when the MWHSV was increased from 0.65 h(-1) to 3.2 h(-1).
Interference avoidance based on multi-step-ahead prediction for cognitive radio (2008)

Opportunistic spectrum access (OSA) which allows a secondary user to access channels when primary users are not transmitting has been considered a promising way to increase the spectrum efficiency. To coexist with the primary user in the same frequency band, the secondary user has to adopt strict interference control rules to avoid interference towards primary users. This paper proposes using interference time ratio (ITR) (i.e. the fraction of a primary user¿s burst that is interfered by secondary transmission) as a measure of how much the primary user is impacted by secondary user for OSA system. A scheme based on multi-step-ahead prediction is proposed to predict the ITR and control the ITR so that it does not exceed a predefined threshold. To further illustrate the proposed interference avoidance scheme, two cases with different primary user traffic model are studied and simulated. The simulation and analysis results show that within acceptable predicting step number, primary user¿s burst could be well protected and precise ITR control could be achieved through the proposed interference avoidance scheme.
Cigarette Smoke–Related Oxidants and the Development of Sub-RPE Deposits in an Experimental Animal Model of Dry AMD (2006)

Exposure to cigarette smoke or the smoke-related redox molecule, HQ, results in the formation of sub-RPE deposits, thickening of Bruch's membrane, and accumulation of deposits within Bruch's membrane. Smoke-related oxidants may be another oxidative injury stimulus to the choriocapillaris and RPE, and may explain the association between cigarette smoking and early AMD.
New methods for the synthesis of proximally functionalized arylboranes and silanes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew methods for the synthesis of proximally functionalized arylboranes and silanesH. E. KatzCite this: Organometallics 1986, 5, 11, 2308–2311Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://doi.org/10.1021/om00142a022RIGHTS & PERMISSIONSArticle Views685Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (565 KB) Get e-Alerts Get e-Alerts
Program Characterization Using Runtime Values and Its Application to Software Plagiarism Detection (2015)

Illegal code reuse has become a serious threat to the software community. Identifying similar or identical code fragments becomes much more challenging in code theft cases where plagiarizers can use various automated code transformation or obfuscation techniques to hide stolen code from being detected. Previous works in this field are largely limited in that (i) most of them cannot handle advanced obfuscation techniques, and (ii) the methods based on source code analysis are not practical since the source code of suspicious programs typically cannot be obtained until strong evidences have been collected. Based on the observation that some critical runtime values of a program are hard to be replaced or eliminated by semantics-preserving transformation techniques, we introduce a novel approach to dynamic characterization of executable programs. Leveraging such invariant values, our technique is resilient to various control and data obfuscation techniques. We show how the values can be extracted and refined to expose the critical values and how we can apply this runtime property to help solve problems in software plagiarism detection. We have implemented a prototype with a dynamic taint analyzer atop a generic processor emulator. Our value-based plagiarism detection method (VaPD) uses the longest common subsequence based similarity measuring algorithms to check whether two code fragments belong to the same lineage. We evaluate our proposed method through a set of real-world automated obfuscators. Our experimental results show that the value-based method successfully discriminates 34 plagiarisms obfuscated by SandMark, plagiarisms heavily obfuscated by KlassMaster, programs obfuscated by Thicket, and executables obfuscated by Loco/Diablo.
Studies on monoterpene glucosides and related natural products. XLI. Chemical conversion of geniposide into 10-hydroxyloganin. (1981)

Geniposide (9) was chemically converted into 10-hydroxyloganin (3a), which is presumed to be a precursor for secologanin (2). The stereoisomers 8a, 18a and 19a were also prepared. The absolute configurations of these four compounds were determined on the basis of chemical reactions and NMR measurements.