gebhart/patrepeval huggingface dataset:
Preface to the third edition (2009)

The first and second editions of Personality Traits explicated and consolidated our opinion that the science of personality could be built on a foundation of traits. The first edition had the job of defining the field. It grew out of the growing consensus regarding traits as entities, and particularly well-validated personality trait models. The second edition was more comfortable in the presence of its psychological neighbours. It absorbed the confidence building around traits and trait models and reached out to companion disciplines that could inform personality trait science and also benefit from it. That maturity and integration was the dual driving force for this third edition. It is no longer necessary primarily to be marking territory, to be showing what is and what is not trait land. In this third edition, with personality traits and their models more securely established and connected within psychology, there is more reaching out: to the revisionary critics, who have some interesting new ideas; to the fast-growing sciences that can offer explanations for trait differences; and to the applied fields that are increasingly enjoying the benefits of including personality trait variance in their models. The structure of the book has been retained. Readers will first find out about the distinctive characteristics of traits, then their biological and social foundations, and then how they play out into human life: what traits are and which ones there are, how differences in them come about, and why they matter.
Statistical Analysis of MPI in Bend-insensitive Fibers (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Li, X. Chen, P. Dainese, J. J. Englebert, C. Saravanos, D. Z. Chen, V. X. Jain, R. C. Ditmore, and G. N. Bell, "Statistical Analysis of MPI in Bend-insensitive Fibers," in Optical Fiber Communication Conference and National Fiber Optic Engineers Conference, OSA Technical Digest (CD) (Optica Publishing Group, 2009), paper OTuL1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Inactivation of human plasma α<sub>1</sub>‐proteinase inhibitor by human PMN leucocyte collagenase (1990)

Highly purified human polymorphonuclear leucocyte collagenase cleaved human alpha-1-proteinase inhibitor (alpha 1-PI) at the carboxyl site of Phe352 (P7). The inhibitor was thereby rapidly inactivated and generated a primary degradation product as shown by reverse-phase HPLC and N-terminal sequencing. Prolonged incubation of the modified inhibitor with polymorphonuclear leucocyte collagenase led to the generation of a secondary degradation product with additional cleavage at the carboxyl site of Pro357 (P2).
Leveraging Program Invariants to Promote Population Diversity in Search-Based Automatic Program Repair (2019)

Search-based automatic program repair has shown promise in reducing the cost of defects in real-world software. However, to date, such techniques have typically been most successful when constructing short or single-edit repairs. This is true even when techniques make use of heuristic search strategies, like genetic programming, that in principle support the construction of patches of arbitrary length. One key reason is that the fitness function traditionally depends entirely on test cases, which are poor at identifying partially correct solutions and lead to a fitness landscape with many plateaus. We propose a novel fitness function that optimizes for both functionality and semantic diversity, characterized using learned invariants over intermediate behavior. Our early results show that this new approach improves semantic diversity and fitness granularity, but does not statistically significantly improve repair performance.
Applications of PC(sp<sup>3</sup>)P Iridium Complexes in Transfer Dehydrogenation of Alkanes (2014)

Iridium ethylene complexes based on the PC(sp3)P pincer-type triptycene ligand have been synthesized. Complexes bearing various substituents on the phosphines have been investigated as catalysts in transfer dehydrogenation of alkanes. The complex 8a, which bears isopropyl groups, has demonstrated high stability and activity when used as a catalyst in the disproportionation of 1-hexene at 180 °C and in the transfer dehydrogenation of linear and cyclic alkanes with tert-butylethylene as a hydrogen acceptor at 200 °C. A similar complex bearing a CH2NMe2 group, 33, allowed support of the catalyst on γ-alumina for operation in a heterogeneous mode.
164. Studies in the sterol group. Part XXXII. The bromination of 6-ketocholestanyl acetate (1937)

I. M. Heilbron, E. R. H. Jones and F. S. Spring, J. Chem. Soc., 1937, 801 DOI: 10.1039/JR9370000801
Low-Dose Targeted Complement Inhibition Protects against Renal Disease and Other Manifestations of Autoimmune Disease in MRL/<i>lpr</i> Mice (2008)

Complement appears to play a dual role in the progression of systemic lupus erythematosus, serving a beneficial role in enhancing immune complex clearance, while serving a pathogenic role in inducing local inflammation. To investigate these different roles of complement in a therapeutic setting, MRL/lpr mice were treated with the targeted murine C3 complement inhibitor, CR2-Crry, from 16 to 24 wk of age (after the development of proteinuria). The targeting moiety, CR2, binds to C3 breakdown products deposited at sites of complement activation and has the potential to provide complement inhibition locally without causing systemic inhibition. Administration of CR2-Crry i.v., at a dose of 0.25 mg once a week, was associated with a significant survival benefit, improved kidney function, and a significant reduction in glomerulonephritis and renal vasculitis. The presence of skin lesions and lung bronchiolar and vascular inflammation was also dramatically reduced by CR2-Crry treatment. CR2-Crry treatment also resulted in a significant reduction in autoantibody production, as measured by anti-dsDNA Ab levels, and did not cause an increase in circulating immune complex levels. These effects on autoimmunity and circulating immune complexes represent significant potential advantages over the use of Crry-Ig in MRL/lpr mice, a systemic counterpart of CR2-Crry. CR2-Crry localized preferentially to the kidneys in 16-wk MRL/lpr mice with a kidney-localized half-life of approximately 24 h. Thus, targeted complement inhibition at the C3 level is an effective treatment in murine lupus, even beginning after onset of disease.
The Feasibility of Water Injection Into the Turbine Coolant to Permit Gas Turbine Contingency Power for Helicopter Application (1983)

A system which would allow a substantially increased output from a turboshaft engine for brief periods in emergency situations with little or no loss of turbine stress rupture life is proposed and studied analytically. The increased engine output is obtained by turbine overtemperature; however, the temperature of the compressor bleed air used for hot section cooling is lowered by injecting and evaporating water. This decrease in cooling air temperature can offset the effect of increased gas temperature and increased shaft speed and thus keep turbine blade stress rupture life constant. The analysis utilized the Navy NASA Engine Program or NNEP computer code to model the turboshaft engine in both design and off-design modes. This report is concerned with the effect of the proposed method of power augmentation on the engine cycle and turbine components. A simple cycle turboshaft engine with a 16:1 pressure ratio and a 1533 K (2760° R) turbine inlet temperature operating at sea level static conditions was studied to determine the possible power increase and the effect on turbine stress rupture life that could be expected using the proposed emergency cooling scheme. The analysis showed a 54 percent increase in output power can be achieved with no loss in gas generator turbine stress rupture life. A 231 K (415° F) rise in turbine inlet temperature is required for this level of augmentation. The required water flow rate was found to be 0.0109 kg water per kg of engine air flow. For a 4.474 MW (6000 shp) engine this would require 32.26 kg (71.13 lbm) of water for a 2.5 min transient. At this power level, approximately 25 percent of the uncooled power turbine life is used up in a 2 1/2-min transient. If the power turbine were cooled, this loss of stress-rupture life could be reduced to zero. Also presented in this report are the results of an analysis used to determine the length of time a ceramic thermal barrier coating would delay the temperature rise in hot parts during operation at elevated temperatures. It was hoped that the thermal barrier could be used as a scheme to allow increased engine output while maintaining the life of hot section parts during short overtemperature transients. The thermal barrier coating was shown to be ineffective in reducing blade metal temperature rise during a 2.5-min overtemperature.
Recovering keys in open networks (2003)

Key recovery has been the subject of a lot of discussion, of much controversy and of extensive research. The widespread opinion of the research community, expressed in a technical report, written by well known experts, is that large-scale deployment of a key recovery system is essentially impossible. Despite this fact, key recovery might be needed at a corporate level, as a form of key management. The basic observation of the present paper is that cryptographic solutions that have been proposed so far, completely ignore the communication context. Surprisingly, static systems are put forward for key recovery at the network layer and solutions that require connections with a server are proposed at the application layer. We give two examples showing that it is possible to take advantage of the communication environment in order to design key recovery protocols that are better suited and more efficient.
The First Enantioselective Organocatalytic Mukaiyama−Michael Reaction:  A Direct Method for the Synthesis of Enantioenriched γ-Butenolide Architecture (2003)

The first enantioselective organocatalytic Mukaiyama-Michael reaction using alpha,beta-unsaturated aldehydes has been accomplished. The use of iminium catalysis has provided a new strategy for the enantioselective addition of 2-silyloxy furans to unsaturated aldehydes to generate a variety of butenolide systems, an important chiral synthon found among many natural isolates. The (2S,5S)-5-benzyl-2-tert-butyl-imidazolidinone amine catalyst has been found to mediate the conjugate addition of a wide variety of substituted and unsubstituted silyloxy furans to unsaturated aldehydes. A diverse range of aldehyde substrates can be accommodated in this new organocatalytic transformation. Application of this new asymmetric technology to the enantioselective total synthesis of spiculisporic acid and the corresponding 5-epi-spiculisporic acid analogue is also discussed.
Synthesis, Structure, and 2D‐NMR Studies of Novel Chiral (η<sup>3</sup>‐Allyl)palladium(II) Complexes Containing the Bidentate Ligand Sparteine (1990)

Abstract Novel cationic allylpalladium (II) comp, exes containing the alkaloid (−)sparteine ( 1 ) as a bidentate ligand have been prepared. Two of them, [η 3 (cyclohex‐2‐enyl)] (sparteine)palladium(II) hexafluorophosphate([Pd(η 3 ‐C 6 H 9 )(sparteine)][PF 6 ] 3b ) and (sparteine)[η 3 ‐(1,1,3‐triphenylallyl)] palladium (II) trifluorophosphate ([Pd(η 3 ‐Ph 2 CCHCHPh)(sparteine)][sparteine)] [CF 3 SO 3 ]; ( 3c ) were characterized by X‐ray diffraction. The application of 2D‐NMR methods (COSY and NOESY)affords a correlation between the solid‐state and solution structures for complex 3c .
Simple, Fast, Accurate Intent Classification and Slot Labeling for Goal-Oriented Dialogue Systems (2019)

With the advent of conversational assistants like Amazon Alexa, Google Now, etc., dialogue systems are gaining a lot of traction, especially in industrial settings. These systems typically include a Spoken Language understanding component which consists of two tasks: Intent Classification (IC) and Slot Labeling (SL). Generally, these two tasks are modeled together jointly to achieve best performance. However, this joint modeling adds to model obfuscation. In this work, we first design framework for a modularization of joint IC-SL task to enhance architecture transparency. Then, we explore a number of selfattention, convolutional, and recurrent models, contributing a large-scale analysis of modeling paradigms for IC+SL across two datasets. Finally, using this framework, we propose a class of 'label-recurrent' models that are nonrecurrent apart from a 10-dimensional representation of the label history, and show that our proposed systems are highly accurate (achieving over 30% error reduction in SL over the state-of-the-art on the Snips dataset), as well as fast, at 2x the inference and 2/3 to 1/2 the training time of comparable recurrent models, thus giving an edge in critical real-world systems.
The levothyroxine spectrum: Bioequivalence and cost considerations (2005)

Levothyroxine, a critical medication for millions of Americans, has had a long and turbulent history. In the face of tougher FDA regulations and especially its reclassification as a new in 1997, manufacturers have struggled to carve out their niche in an expansive market. The principal concern of physicians, patients, endocrinologists, manufacturers, and FDA is levothyroxine's relative bioequivalence. Even after FDA classified several products as bioequivalent, a single brand name product still holds most of the market share, despite the fact that it is more costly. Current issues surrounding levothyroxine include: controversy about research, the number and types of recalls, the lack of a single reference-listed drug for comparison, and conflicting claims about the bioequivalence of various formulations.
Use of remazol blue dyed avicel for the determination of cellulolytic activity in basidiomycetes (1998)

A modified method for direct determination of cellulolytic activity using Avicel colored with Remazol Brilliant Blue R (RBBR) in Agar test tubes is discussed. Refinements were introduced in a simple method for quantitation of cellulase activity, based on the release of dye from Avicel-RBBR medium by the enzymatic hydrolysis. Modifications in Avicel-dye preparation were enhanced and a spectrophotometer for direct OD measurement in agar test tubes used. The use of a spectrophotometer improved the precision of the collected data, since absorbance measurements could be done at the maximum wavelenght for RBBR (595 nm).
PHOTON DIFFUSION IN BREAST AND BRAIN: SPECTROSCOPY AND IMAGING (1993)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text BRITTON CHANCE, KYUNG KANG, and EVA SEVICK, "PHOTON DIFFUSION IN BREAST AND BRAIN: SPECTROSCOPY AND IMAGING," Optics & Photonics News 4(10), 9-13 (1993) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The Eukaryotic DNMT2 Genes Encode a New Class of Cytosine-5 DNA Methyltransferases (2003)

DNMT2 is a subgroup of the eukaryotic cytosine-5 DNA methyltransferase gene family. Unlike the other family members, proteins encoded by DNMT2 genes were not known before to possess DNA methyltransferase activities. Most recently, we have shown that the genome of Drosophila S2 cells stably expressing an exogenous Drosophila dDNMT2 cDNA became anomalously methylated at the 5'-positions of cytosines (Reddy, M. N., Tang, L. Y., Lee, T. L., and Shen, C.-K. J. (2003) Oncogene, in press). We present evidence here that the genomes of transgenic flies overexpressing the dDnmt2 protein also became hypermethylated at specific regions. Furthermore, transient transfection studies in combination with sodium bisulfite sequencing demonstrated that dDnmt2 as well as its mouse ortholog, mDnmt2, are capable of methylating a cotransfected plasmid DNA. These data provide solid evidence that the fly and mouse DNMT2 gene products are genuine cytosine-5 DNA methyltransferases.
Semiochemicals of the common bed bug, <i>Cimex lectularius</i> L. (Hemiptera: Cimicidae), and their potential for use in monitoring and control (2010)

The recent resurgence of the common bed bug, Cimex lectularius L., has driven an increase in research into the biology and behaviour of this pest. Current control is reliant on the application of insecticides, but, owing to the development of insecticide resistance, there is a need for new tools and techniques. Semiochemicals (behaviour- and physiology-modifying chemicals) could be exploited for management of bed bugs. The aim of this review was to evaluate studies undertaken in bed bug chemical ecology to date, with particular reference to how the research could be exploited for monitoring and control. Bed bugs, like many other insects, have a complex olfactory system. Recent studies have characterised the olfactory sensilla, located on the terminal segment of the antennae, to functional classes by electrophysiological screening. Behavioural studies have revealed the presence of an alarm pheromone and potential airborne aggregation semiochemicals, but it is not yet understood if bed bugs use a sex pheromone during mating. Host location cues have been investigated, and carbon dioxide has been found to be highly attractive both in laboratory and in field studies. Recent field trials have tested blends of other potential kairomones, which have been shown to have an additive effect when used in a heated bed bug trap with carbon dioxide. The trap, which combines heat and kairomones, is the only trap currently available with proven efficacy in the field. In order for semiochemicals to be useful for bed bug management, an increased knowledge and understanding of the biology, behaviour and chemical ecology of this insect is essential.
Inactivation of the yellow strain of cucumber mosaic virus by pancreatic ribonuclease. (1986)

The infectivity of cucumber mosaic virus Y strain (CMV-Y) decreased after mixing with bovine pancreatic ribonuclease (RNase). The amount of infectivity lost was dependent on the virus to enzyme ratio in the mixture and on the pH used for incubation. The enzyme seemed to bind at random to the surface of virus particles. Binding was partially reversed by pH adjustment. Most of the RNase which attached to the virus at pH 6 appeared to be released at pH 8. As the proportion of RNase in mixtures increased, the virus particles and enzyme formed complex aggregates. Degradation of virions occurred only at very high RNase concentrations. Degradation occurred more rapidly at pH 6 than pH 8. The infectivity loss upon addition of small amounts of RNase appeared not to be caused by aggregation or virion degradation. It is suggested that RNase attached to the virus prevents some processes necessary for initiation of infection or attacks the uncoated RNA.
Analysis, Synthesis and Design of Hydraulic Servosystems and Pipelines (1981)

Analysis, synthesis, and design of hydraulic servosystems and pipelines , Analysis, synthesis, and design of hydraulic servosystems and pipelines , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
End-to-end web application security (2007)

Splicing of pre‐mRNAs is a necessary step for expression of the majority of genes in higher eukaryotes, and its regulation through alternative splice site selection shapes their proteomes. Defects in multiple splicing factors result in aberrant mitotic progression, although the molecular basis for this observation has remained elusive. Recent papers in The EMBO Journal and EMBO Reports reveal that expression of sororin, a critical regulator that stabilizes cohesin rings in sister chromatids, is exquisitely sensitive to defects in the splicing machinery, thus explaining the striking link between spliceosome function and chromosome segregation.
Path tracking with IGPS (2010)

iGPS technology is a laser-based indoor system with optical sensors and transmitters to determine the 3D/4D position of static or moving objects. The technology is based on internal time measurements related to spatial rays that intersect at sensors in the measuring volume. The static iGPS accuracy is well known, but there is a lack of testing the tracking accuracy with the latest system developments. Due to the measurement principle of iGPS, tracking measurements can caused a delay time which will lead to deviations in spatiotemporal positioning. Utilizing the new Digital Input Module it is possible to examine the iGPS system with the time-referenced 4D test and calibration system (Ti4Calibs). By using the latest equipment and Surveyor software it was possible to show that the iGPS system has made significant improvement in tracking capability. In this paper measuring result examples are represented in order to show the iGPS performance under kinematic conditions (time and space). Velocities up to 3 m/s were reached and at this high velocity the tracking deviations for the 3D position were less than 0.3 mm and the 4D tracking deviations were less than 1.5 mm. These results show that Nikon has reached to reduce the theoretical delay time and that iGPS is not only a static metrology system but also capable for tracking applications.
A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation (2017)

The Cullin-RING E3 ubiquitin ligases (CRLs) regulate homeostasis of ~20% of cellular proteins and their activation require neddylation of their cullin subunit. Cullin neddylation is modulated by a scaffolding DCN protein through interactions with both the cullin protein and an E2 enzyme such as UBC12. Here we report the development of DI-591 as a high-affinity, cell-permeable small-molecule inhibitor of the DCN1-UBC12 interaction. DI-591 binds to purified recombinant human DCN1 and DCN2 proteins with K <sub>i</sub> values of 10-12 nM, and disrupts the DCN1-UBC12 interaction in cells. Treatment with DI-591 selectively converts cellular cullin 3 into an un-neddylated inactive form with no or minimum effect on other cullin members. Our data firmly establish a previously unrecognized specific role of the DCN1-UBC12 interaction for cellular neddylation of cullin 3. DI-591 is an excellent probe compound to investigate the role of the cullin 3 CRL ligase in biological processes and human diseases.
Homo‐ and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment (2009)

Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are the most common cause of autosomal-dominant familial and late-onset sporadic Parkinson's disease (PD). LRRK2 is a large multi-domain protein featuring a GTP-binding C-terminal of Ras of complex proteins (ROC) (ROCO) domain combination unique for the ROCO protein family, directly followed by a kinase domain. Dimerization is a well-established phenomenon among protein kinases. Here, we confirm LRRK2 self-interaction, and provide evidence for general homo- and heterodimerization potential among the ROCO kinase family (LRRK2, LRRK1, and death-associated protein kinase 1). The ROCO domain was critically, though not exclusively involved in dimerization, as a LRRK2 deletion mutant lacking the ROCO domain retained dimeric properties. GTP binding did not appear to influence ROCO(LRRK2) self-interaction. Interestingly, ROCO(LRRK2) fragments exerted an inhibitory effect on both wild-type and the elevated G2019S LRRK2 autophosphorylation activity. Insertion of PD mutations into ROCO(LRRK2) reduced self-interaction and led to a reduction of LRRK2 kinase inhibition. Collectively, these results suggest a functional link between ROCO interactions and kinase activity of wild-type and mutant LRRK2. Importantly, our finding of ROCO(LRRK2) fragment-mediated LRRK2 kinase inhibition offers a novel lead for drug design and thus might have important implications for new therapeutic avenues in PD.