gebhart/patrepeval huggingface dataset:
Magnetic Deflection of Kinescopes (1947)

This paper investigates some basic principles in the operation of systems for magnetic deflection of television tubes. In the first part, the energy of the deflecting field is calculated for various deflection angles and beam voltages. It is found that sweep amplifiers are preferably operated with a positive rate of change of plate current. This causes a considerable plate-voltage drop, for which expressions are given. The efficiency of sweep generators is discussed and a method is indicated to determine the power dissipation in the sweep output amplifier. The second part deals with the transients during the retrace and their elimination. A theory is given for resistance damping. Practical results are presented for a special method of damping by secondary emission within the sweep amplifier. In part three, some basic forms of sweep distortion are discussed and means for their correction are indicated. Two characteristic distortions are found to be due to the resistive components of either the tube or the load. These distortions are of opposite sign. Nonlinearity of the tube characteristic is found equivalent to an emphasis of low-frequency components in the spectrum of a sawtooth wave. The fourth part describes a sweep circuit of improved efficiency. This circuit operates with power feedback and uses a diode as switching element. Flyback energy is rectified and the resulting direct-current power added to the plate power supply.
A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis† ‡ (2004)

Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease for which there is no known effective therapy. A proportion of patients with NASH progress to advanced fibrosis and cirrhosis. NASH is considered one of the clinical features of the metabolic syndrome in which insulin resistance plays a central role. This prospective study evaluates the role of insulin-sensitizing agent in treatment of NASH. Eighteen nondiabetic patients with biopsy-proven NASH were treated with pioglitazone (30 mg daily) for 48 weeks. Tests of insulin sensitivity and body composition as well as liver biopsies were performed before and at the end of treatment. By 48 weeks, serum alanine aminotransferase values fell to normal in 72% of patients. Hepatic fat content and size as determined by magnetic resonance imaging decreased, and glucose and free fatty acid sensitivity to insulin were uniformly improved. Histological features of steatosis, cellular injury, parenchymal inflammation, Mallory bodies, and fibrosis were significantly improved from baseline (all P < 0.05). Using strict criteria, histological improvement occurred in two-thirds of patients. Pioglitazone was well tolerated; the main side effects were weight gain (averaging 4%) and an increase in total body adiposity. In conclusion, these results indicate that treatment with an insulin-sensitizing agent can lead to improvement in biochemical and histological features of NASH and support the role of insulin resistance in the pathogenesis of this disease. The long-term safety and benefits of pioglitazone require further study.
The Discoidin Domain of<i>Bacillus circulans</i>β-Galactosidase Plays an Essential Role in Repressing Galactooligosaccharide Production (2013)

The recently cloned β-galactosidase from Bacillus circulans ATCC 31382, designated BgaD, contains a multiple domain architecture including a F5/8 type C domain or a discoidin (DS) domain in the C-terminal peptide region. Here we report that the DS domain plays an essential role in repressing the production of galactooligosaccharides (GOSs). We prepared deletion mutants and point-mutated forms of rBgaD-A (deletion of the BgaD signal peptide) to compare their reaction behaviors. The yields of GOSs for all of the point-mutated forms as well as the deletion mutants of rBgaD-As increased as compared to rBgaD-A. In particular, W1540A mutant BgaD-A (rBgaD-A_W1540A) produced much more GOSs than rBgaD-A. Surface plasmon resonance experiments indicated that both the wild-type and the W1540A mutant DS domains showed high affinity for galactosyllactose. rBgaD-A, which has a wild-type DS domain, showed high hydrolytic activity toward galactosyllactose, while the hydrolytic activities of rBgaD-D, without a DS domain, and rBgaD-A_W1540A, with a mutant DS domain were extremely low. The findings obtained in this study indicate that the wild-type DS domain of rBgaD-A has a function that aids galactosyllactose molecules to be properly oriented within the active site, so that they can be hydrolyzed efficiently to produce galactose/glucose by inhibiting the accumulation of GOSs.
Development of Ultra-Low Pt Alloy Cathode Catalyst for PEM Fuel Cells (2013)

Hybrid cathode catalysts containing Pt (Pt/CCC, HCC-1) and Pt-alloy (Pt-alloy/CCC, HCC-2) with ultra-low Pt loading were synthesized as cathode catalysts for polymer electrolyte membrane fuel cells (PEMFC). The approach combines a non-platinum carbon based composite catalyst (CCC) containing active catalytic sites for the oxygen reduction reaction (ORR) as a support and highly active Pt/Pt-alloy catalysts. Rotating ring disc electrode (RRDE) and fuel cell studies confirmed the synergistic effect of combining CCC and Pt/Pt-alloy. The HCC catalysts exhibited 2-3 times higher mass activities (0.35 - 0.45 A mgPt-1) than the conventional Pt/C catalyst (0.18-0.24 A mgPt-1). The HCC-2 catalyst exhibited H2-air fuel cell performance of 1.4 A cm-2 at 0.58 ViR-free at a cathode stoic of 2.0.
The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk (2017)

L. iners dominance of the vaginal microbiota at 16 weeks of gestation is a risk factor for preterm birth, whereas L. crispatus dominance is protective against preterm birth. Vaginal progesterone does not appear to impact the pregnancy vaginal microbiota. Patients and clinicians who may be concerned about "infection risk" associated with the use of a vaginal pessary during high-risk pregnancy can be reassured.
Serum Protein and Casein Concentration: Effect on pH and Freezing Point of Milk with Added CO2 (2003)

The objective of this study was to determine the effect of protein concentration and protein type [i.e., casein (CN) and serum protein (SP)] on pH (0 degree C) and freezing point (FP) of skim milk upon CO2 injection at 0 degree C. CN-free skim milks with increasing SP content (0, 3, and 6%) and skim milks with the same SP content (0.6%) but increasing CN content (2.4, 4.8, and 7.2%) were prepared using a combination of microfiltration and ultrafiltration processes. CO2 was injected into milks at 0 degree C using a continuous flow carbonation unit (230 ml/min). Increasing SP or CN increased milk buffering capacity and protein-bound mineral content. At the same CO2 concentration at 0 degree C, a milk with a higher SP or a higher CN concentration had more resistance to pH change and a greater extent of FP decrease. The buffering capacity provided by an increase of CN was contributed by both the CN itself and the colloidal salts solublized into the serum phase from CN upon carbonation. Skim milks with the same true protein content (3%), one with 2.4% CN plus 0.6% SP and one with 3% SP, were compared. At the same true protein content (3%), increasing the proportion of CN increased milk buffering capacity and protein-bound mineral content. Milk with a higher proportion of CN had more resistance to pH change and a greater extent of FP decrease at the same carbonation level at 0 degree C. Once CO2 was dissolved in the skim portion of a milk, the extent of pH reduction and FP depression depended on protein concentration and protein type (i.e., CN and SP).
Expansion of Foxp3<sup>+</sup> T‐cell populations by <i>Candida albicans</i> enhances both Th17‐cell responses and fungal dissemination after intravenous challenge (2014)

Candida albicans remains the fungus most frequently associated with nosocomial bloodstream infection. In disseminated candidiasis, the role of Foxp3(+) regulatory T (Treg) cells remains largely unexplored. Our aims were to characterize Foxp3(+) Treg-cell activation in a murine intravenous challenge model of disseminated C. albicans infection, and determine the contribution to disease. Flow cytometric analyses demonstrated that C. albicans infection drove in vivo expansion of a splenic CD4(+) Foxp3(+) population that correlated positively with fungal burden. Depletion from Foxp3(hCD2) reporter mice in vivo confirmed that Foxp3(+) cells exacerbated fungal burden and inflammatory renal disease. The CD4(+) Foxp3(+) population expanded further after in vitro stimulation with C. albicans antigens (Ags), and included at least three cell types. These arose from proliferation of the natural Treg-cell subset, together with conversion of Foxp3(-) cells to the induced Treg-cell form, and to a cell type sharing effector Th17-cell characteristics, expressing ROR-γt, and secreting IL-17A. The expanded Foxp3(+) T cells inhibited Th1 and Th2 responses, but enhanced Th17-cell responses to C. albicans Ags in vitro, and in vivo depletion confirmed their ability to enhance the Th17-cell response. These data lead to a model for disseminated candidiasis whereby expansion of Foxp3(+) T cells promotes Th17-cell responses that drive pathology.
Fast Straight Lines Detection Using Hough Transform with Principal Axis Analysis (2003)

Hough Transform is a sound method for detecting straight lines in digital images. Considering an image with lattice structure, we modify the procedure in detecting straight lines using Hough Transform. We propose a Principal Axis Analysis Method to speed up the extraction of straight lines and increase the accuracy of the detected lines. We first transfer the parameters to a one-dimensional angle-count histogram, and then analyze the dominated distribution of image features. In peak detection, the searching priority is set according to the principal axis. Experimental results indicate that the accuracy and the efficiency for all of the cases are improved. The efficiency is better improved when the objects in an image are with more regularity.
Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an <i>in vivo</i> microdialysis study in mice (2004)

Abstract Substance P antagonists of the neurokinin-1 receptor type (NK1) are gaining growing interest as new antidepressant therapies. It has been postulated that these drugs exert this putative therapeutic effect without direct interactions with serotonin (5-HT) neurones. Our recent microdialysis experiment performed in NK1 receptor knockout mice suggested evidence of changes in 5-HT neuronal function (Froger et al. 2001). The aim of the present study was to evaluate the effects of coadministration of the selective 5-HT reuptake inhibitor (SSRI) paroxetine with a NK1 receptor antagonist (GR205171 or L733060), given either intraperitoneally (i.p.) or locally into the dorsal raphe nucleus, on extracellular levels of 5-HT ([5-HT]ext) in the frontal cortex and the dorsal raphe nucleus using in vivo microdialysis in awake, freely moving mice. The systemic or intraraphe administration of a NK1 receptor antagonist did not change basal cortical [5-HT]ext in mice. A single systemic dose of paroxetine (4 mg/kg; i.p.) resulted in a statistically significant increase in [5-HT]ext with a larger extent in the dorsal raphe nucleus (+ 138% over basal AUC values), than in the frontal cortex (+ 52% over basal AUC values). Co-administration of paroxetine (4 mg/kg; i.p.) with the NK1 receptor antagonists, GR205171 (30 mg/kg; i.p.) or L733060 (40 mg/kg; i.p.), potentiated the effects of paroxetine on cortical [5-HT]ext in wild-type mice, whereas GR205171 (30 mg/kg; i.p.) had no effect on paroxetine-induced increase in cortical [5-HT]ext in NK1 receptor knock-out mice. When GR205171 (300 micro mol/L) was perfused by 'reverse microdialysis' into the dorsal raphe nucleus, it potentiated the effects of paroxetine on cortical [5-HT]ext, and inhibited paroxetine-induced increase in [5-HT]ext in the dorsal raphe nucleus. Finally, in mice whose 5-HT transporters were first blocked by a local perfusion of 1 micro mol/L of citalopram into the frontal cortex, a single dose of paroxetine (4 mg/kg i.p.) decreased cortical 5-HT release, and GR205171 (30 mg/kg i.p.) reversed this effect. The present findings suggest that NK1 receptor antagonists, when combined with a SSRI, augment 5-HT release by modulating substance P/5-HT interactions in the dorsal raphe nucleus.
Characterization of <i>Pythium</i> spp. from Three Ohio Fields for Pathogenicity on Corn and Soybean and Metalaxyl Sensitivity (2004)

Pythium spp. were baited with corn and soybean seed from soils collected from three locations in Ohio where soybean and corn stand establishment was a concern. Five species, P. catenulatum, P. irregulare, P. paroecandrum, P. splendens, and P. torulosum, were recovered and a subset of these isolates was then tested for pathogenicity on corn and soybean seed and sensitivity to the seed treatment fungicide metalaxyl. There was a range of both pathogenicity and sensitivity to metalaxyl within and among the Pythium spp. recovered from the three locations. A more thorough evaluation of the Pythium populations that exist in grain production fields in the north central region of the US is needed to facilitate the development and deployment of broader based seed treatment products. Accepted for publication 12 January 2004. Published 2 February 2004.
IIb Group Metal Ions (Zn2+, Cd2+, Hg2+) Stimulate Glucose Transport Activity by Post-insulin Receptor Kinase Mechanism in Rat Adipocytes (1989)

Zn2+ (1 mM), Cd2+ (1 mM), and Hg2+ (0.1 mM) belonging to the IIb group in the periodic table stimulated glucose transport activity and cAMP phosphodiesterase in rat adipocytes. The stimulation of glucose transport was due to the translocation of glucose transporters from the intracellular site to the plasma membrane. However, in intact adipocytes none of these ions stimulated insulin receptor kinase activity or phosphorylation of the 95-kDa subunit of insulin receptor or 170- or 60-kDa proteins at the tyrosyl residues. These proteins were markedly phosphorylated by addition of 0.3 nM insulin which stimulated glucose transport activity as effectively as these metal ions. These results indicate that Zn2+, Cd2+, and Hg2+ mimic insulin action by a post-receptor/kinase mechanism.
Design of a quadrature clock conditioning circuit in 90-nm CMOS technology (2008)

This paper presents the operation and problems of the conventional clock conditioning circuits. A modified design is proposed to eliminate these problems and to merge two conditioning circuits together. This is to adjust and maintain two output signal properties actively during circuit operation for 4-phase 10 GHz single-ended clock signals. It is desired to have an exact 50% duty-cycle for each signal and a 90° phase difference between them. Simulation results in 90-nm CMOS technology are provided showing low output jitter.
Tight Junction, a Platform for Trafficking and Signaling Protein Complexes (2000)

Epithelial cells are associated laterally in a sheet, with the apical surface facing the lumina, often covered by microvilli, and the basolateral side underlying connective tissue. Development and maintenance of epithelial polarity require cell–substrate and cell–cell adhesions that promote
STORAGE OF SEROTONIN AND SEROTONIN BINDING PROTEIN IN SYNAPTIC VESICLES (1979)

Abstract We have used the newly introduced method of D e L orenzo & F reedman (1978) for isolating synaptic vesicles to determine if such vesicles contain both serotonin (5‐HT) and serotonin binding protein (SBP). Two fractions were obtained. A 55, 000 g fraction was morphologically heterogeneous and contained coated vesicles. A 135, 0000 vesicle (dia. 51.3 nm) fraction was homogeneous in ultra‐structure and contained no coated vesicles. The specific activity of SBP in this fraction was much higher than that in the supernatant. Unlike SBP, very little lactic dehydrogenase activity appeared in the 135, 000 g fraction. Qualitative and quantitative differences were observed between the polypeptide profiles of soluble proteins extracted from the vesicles and supernatant proteins on SDS gels. Therefore, entrapment of cytosol in the vesicles of the 135, 000 g fraction was minimal. The 5‐HT concentration of the 135, 000 g vesicles was 5.5 ng/mg protein and in the supernatant, 11.3 ng/mg protein. The ATP concentration in the 135, 000 g vesicle fraction was only 0.8 ng/mg Pr. Rabbit spinal cords were transected in order to determine if SBP is moved proximo‐distally in axons by rapid axonal transport as would be predicted for a constituent of synaptic vesicles. SBP accumulated above the cut at a rate consistent with fast transport (78 mm/day). SBP activity fell caudal to the point of transection and there was no evidence, such as an accumulation below the lesion, that might indicate retrograde transport of SBP. These experiments indicate that SBP is probably synthesized in the cell bodies of serotonergic neurons and some is rapidly transported down axons to be stored in terminals in vesicles.
C3-cleaving membrane proteinase. A new complement regulatory protein of human melanoma cells. (1990)

Human melanoma cells resistant to killing by the R24 mAb and human complement rapidly degrade surface-deposited C3b (M. Panneerselvam, S. Welt, L. J. Old, C.-W. Vogel. 1986. J. Immunol. 136:2534). We report that C-resistant melanoma cells express a membrane proteinase that can cleave C3b, generating a cleavage product with a molecular mass of approximately 30 kDa. The C3-cleaving proteinase was identified on the melanoma cells by its cross-reaction with antiserum to p57, a C3-cleaving proteinase previously isolated from human E membranes (C. Charriaut-Marlangue, M. Barel, R. Frade. 1986. Biochem. Biophys. Res. Commun. 140:1113). Preincubation of the C-resistant melanoma cells with anti-p57 IgG or their F(ab')2 fragments increased their susceptibility to complement killing from 25% to approximately 50% and reduced the rate of C3b cleavage and the amount of the 30-kDa fragment generated on the cells. Anti-p57 IgG stained C-resistant melanoma cells by indirect immunofluorescence and precipitated a protein with an apparent molecular mass of 65 kDa. This membrane protein, termed p65, was not detectable on C-susceptible melanoma cells. Membrane extracts from C-resistant melanoma cells also showed C3-cleaving activity when incubated with purified C3 or C3b, similarly generating a C3 fragment of approximately 35 kDa. This fluid-phase C3 cleaving activity could be partially inhibited by anti-p57 IgG. These data suggest that p65 is a C3-cleaving proteinase, antigenically related to p57, that is expressed on C-resistant melanoma cells and responsible for the C resistance of these cells. We propose that the membrane-bound C3-cleaving proteinase represents another C regulatory protein protecting host cells against killing by C.
Adsorption hysteresis in nanopores (2000)

Capillary condensation hysteresis in nanopores is studied by Monte Carlo simulations and the nonlocal density functional theory. Comparing the theoretical results with the experimental data on low temperature sorption of nitrogen and argon in cylindrical channels of mesoporous siliceous molecular sieves of MCM-41 type, we have revealed four qualitatively different sorption regimes depending on the temperature and pore size. As the pore size increases at a given temperature, or as the temperature decreases at a given pore size, the following regimes are consequently observed: volume filling without phase separation, reversible stepwise capillary condensation, irreversible capillary condensation with developing hysteresis, and capillary condensation with developed hysteresis. We show that, in the regime of developed hysteresis (pores wider than 5 nm in the case of nitrogen sorption at 77 K), condensation occurs spontaneously at the vaporlike spinodal while desorption takes place at the equilibrium. A quantitative agreement is found between the modeling results and the experimental hysteresis loops formed by the adsorption-desorption isotherms. The results obtained provide a better understanding of the general behavior of confined fluids and the specifics of sorption and phase transitions in nanomaterials.
Enforcing Access Control Using Risk Assessment (2007)

Context-based access control is an emerging approach for modeling adaptive solution, making access control management more flexible and powerful. But in the ubiquitous environment, this approach is not enough for many emerging security vulnerabilities. Thus, improving current access control mechanisms is still necessary. Risk is an effective tool used for decision-making in economics. In this paper, we design a new model for risk assessment in ubiquitous environment and use risk as a key component in decision-making process in our access control model. This solution makes access control management more dynamic and precise
A polarization selective surface for circular polarization (2003)

The authors develop surfaces which will transmit a circularly polarized incident wave of one circularity and reflect a wave of opposite circular polarization. Preliminary results for typical circular polarization selective surfaces are given. These results clearly provide the proof of this principle. The results are expected to improve with the use of more accurate methods of construction of these panels. These surfaces would be ideal for use in cm- and mm-wave regions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reduced measles immunity in infants in a well-vaccinated population (1992)

The recommended age for measles vaccination is based in part on information gathered when most mothers had natural measles. Nowadays many mothers have received measles vaccine. To assess this change measles antibody neutralization titers (NT) were determined for 278 mother-infant pairs. One hundred sixty-four mothers, born before 1958, likely had had natural measles (Group 1). Sixty mothers received one to three killed plus one attenuated measles vaccination (Group 2) and 54 received 1 attenuated measles vaccination only (Group 3). NT were determined for the mother and for the infant at birth and in the infant during the fourth and sixth months. Group 1 mothers and infants at every age had higher geometric mean NT than those in Groups 2 or 3 (P less than 0.05). By 7 months 65% of Group 1 infants and greater than 90% of Group 2 and 3 infants had an NT less than 1:10. The rate of antibody decay was significantly faster for Group 1 infants (P less than 0.05). Earlier vaccination in the infant should be considered.
Voltage Clamp Circuits for a Power MOSFET PWM Inverter (1987)

Power MOSFETs are fast-switching devices suitable for high-frequency operations. However, high-speed switching and circuit inductance may cause voltage spikes to appear across the device and damage it. Three types of voltage clamp circuits that can be used with power MOSFETs are considered, and their essential features and characteristics are studied. The different modes of operation with these clamp circuits are discussed, and the design equations to determine these parameters in each clamp circuit are presented. The losses in the three clamp circuits are evaluated and compared. One clamp circuit is shown to offer outstanding advantages and is found to be suitable for high-frequency applications such as PWM inverters.