gebhart/patrepeval huggingface dataset:
Tesis doctoral: Análisis del contenido en agua en formaciones salinas. Su aplicación al almacenamiento de residuos radioactivos (1994)

Rock salt formations are one of the suitable host rocks for high radioactive waste disposal. Among the site selection criteria, one of great importance is the presence of water in the host rock. Due to their genesis and to their mineralogical composition salt formations always contain small amounts of water. This water can be present as interstitial brine, in hydrated minerals and as intragranular fluid inclusions. In order to define the range of water content present in rock salt, as well as its relation between mineralogy and stratigraphical position, fi ve rock salt types have been studied. For each sample water content and also mineralogical analysis has been performed. In most of the studied samples water is present as interstitial bnne and fluid inclusions. In some cases water can also be present in form of hydrated minerals. The distribution of the water content is usually of lognormal type. In some rock salt formations, severa1 subpopulations could be found. Total water content ranges from 0.01 to 3.50%. Mathematical treatment on the aforementioned data consisted of the estimation of the error related to the sampling procedure, statistical tests (univariant, ANOVA, correlation, PCA and trend analysis) and Geostatistics. These treatments have allowed to discern between waternch and water-poor rock salt and also to confirm that there are three factors controlling the amount of water content: mineralogical composition, halitic lithofacies and degree of tectonic stresses. Geostatistical analysis has shown that for detailed characterization purposes a sarnpling interval of 1 m is convenient, whereas for a first characterization of a salt formation a sampling interval of 5 m seems reasonable. Finally, trend analysis has confirmed that along a rock salt formation, alternancy of water-rich and water-poor zones may exist. The methodology described in this study can be very useful for site characterization purposes. Data arising from laboratory research on the aforementioned parameters combined with safety assessment methods can provide the technical basis to decide whether the proposed disposal site offers a satisfactory leve1 of safety.
4/spl times/4 space-switch based on clamped-gain semiconductor optical amplifiers in a 16/spl times/10 Gbit/s WDM experiment (1996)

Suitability of a lossless 4/spl times/4 space-switch based on clamped-gain-SOA for multichannel applications is validated in a 16/spl times/10 Gbit/s experiment. The factors potentially limiting the input power dynamic range are also discussed. The results confirm the exceptional advantages of CG-SOAs for optical switching applications, including splitting loss compensation, high speed control, high ON/OFF ratio and full compatibility with WDM systems.
An improved active-front-end rectifier using model predictive control (2015)

This paper investigates an improved active-front-end (AFE) rectifier using model predictive control. The model predictive control (MPC) algorithm utilizes the discrete behavior of the power converter to determine the appropriate switching states by defining a cost function. The performance of the AFE rectifier has been verified with 3.0 kW experimental setup which shows that the efficiency of the MPC controlled AFE-rectifier is 96.82% and is operated with acceptable THD (4.0%) of input current and very low DC voltage ripple. An efficiency comparison is performed between the MPC and VOC-based PWM controller of the AFE rectifier which ensures the effectiveness of MPC controller. Moreover, the stability of the MPC method has been analyzed with the root locus, discrete z-domain frequency response techniques (Nyquist diagram) and non-linear experimental system. The result confirms that, the control system of AFE rectifier is stable as it operates with infinite gain margin and very fast dynamic response.
Photonic band gap in 1D multilayers made by alternating SiO2 or PMMA with MoS2 or WS2 monolayers (2015)

Atomically thin molybdenum disulfide (MoS2) and tungsten disulfide (WS2) are very interesting two dimensional materials for optics and electronics. In this work we show the possibility to obtain one-dimensional photonic crystals consisting of low-cost and easy processable materials, as silicon dioxide (SiO2) or poly methyl methacrylate (PMMA), and of MoS2 or WS2 monolayers. We have simulated the transmission spectra of the photonic crystals using the transfer matrix method and employing the wavelength dependent refractive indexes of the materials. This study envisages the experimental fabrication of these new types of photonic crystals for photonic and light emission applications.
Motion Planning (2006)

Part II makes the transition from discrete to continuous state spaces. Two alternative titles are appropriate for this part: 1) motion planning, or 2) planning in continuous state spaces. Chapters 3–8 are based on research from the field of motion planning, which has been building since the 1970s; therefore, the name motion planning is widely known to refer to the collection of models and algorithms that will be covered. On the other hand, it is convenient to also think of Part II as planning in continuous spaces because this is the primary distinction with respect to most other forms of planning.
Bone Marrow Transplantation after the Chernobyl Nuclear Accident (1989)

On April 26, 1986, an accident at the Chernobyl nuclear power station in the Soviet Union exposed about 200 people to large doses of total-body radiation. Thirteen persons exposed to estimated total-body doses of 5.6 to 13.4 Gy received bone marrow transplants. Two transplant recipients, who received estimated doses of radiation of 5.6 and 8.7 Gy, are alive more than three years after the accident. The others died of various causes, including burns (the cause of death in five), interstitial pneumonitis (three), graft-versus-host disease (two), and acute renal failure and adult respiratory distress syndrome (one). There was hematopoietic (granulocytic) recovery in nine transplant recipients who could be evaluated, six of whom had transient partial engraftment before the recovery of their own marrow. Graft-versus-host disease was diagnosed clinically in four persons and suspected in two others. Although the recovery of endogenous hematopoiesis may occur after exposure to radiation doses of 5.6 to 13.4 Gy, we do not know whether it is more likely after the transient engraftment of transplanted stem cells. Because large doses of radiation affect multiple systems, bone marrow recovery does not necessarily ensure survival. Furthermore, the risk of graft-versus-host disease must be considered when the benefits of this treatment are being weighed.
Peroxynitrite-Driven Mechanisms in Diabetes and Insulin Resistance – the Latest Advances (2011)

Since its discovery, peroxynitrite has been known as a potent oxidant in biological systems, and a rapidly growing body of literature has characterized its biochemistry and role in the pathophysiology of various conditions. Either directly or by inducing free radical pathways, peroxynitrite damages vital biomolecules such as DNA, proteins including enzymes with important functions, and lipids. It also initiates diverse reactions leading eventually to disrupted cell signaling, cell death, and apoptosis. The potential role and contribution of this deleterious species has been the subject of investigation in several important diseases, including but not limited to, cancer, neurodegeneration, stroke, inflammatory conditions, cardiovascular problems, and diabetes mellitus. Diabetes, obesity, insulin resistance, and diabetes-related complications represent a major health problem at epidemic levels. Therefore, tremendous efforts have been put into investigation of the molecular basics of peroxynitrite-related mechanisms in diabetes. Studies constantly seek new therapeutical approaches in order to eliminate or decrease the level of peroxynitrite, or to interfere with its downstream mechanisms. This review is intended to emphasize the latest findings about peroxynitrite and diabetes, and, in addition, to discuss recent and novel advances that are likely to contribute to a better understanding of peroxynitrite-mediated damage in this disease.
The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization (2007)

Cell polarization is required for virtually all functions of T cells, including transendothelial migration in response to chemokines. However, the molecular pathways that establish T cell polarity are poorly understood. We show that the activation of the partitioning defective (Par) polarity complex is a key event during Rap1- and chemokine-induced T cell polarization. Intracellular localization and activation of the Par complex are initiated by Rap1 and require Cdc42 activity. The Rac activator Tiam1 associates with both Rap1 and components of the Par complex, and thereby may function to connect the Par polarity complex to Rap1 and to regulate the Rac-mediated actin remodelling required for T cell polarization. Consistent with these findings, Tiam1-deficient T cells are impaired in Rap1- and chemokine-induced polarization and chemotaxis. Our studies implicate Tiam1 and the Par polarity complex in polarization of T cells, and provide a mechanism by which chemokines and Rap1 regulate T cell polarization and chemotaxis.
Up‐regulation of [<sup>3</sup>H]‐des‐Arg<sub>10</sub>‐kallidin binding to the bradykinin B<sub>1</sub>receptor by interleukin‐1β in isolated smooth muscle cells: correlation with B<sub>1</sub>agonist‐induced PGI<sub>2</sub>production (1994)

1. Binding of the specific bradykinin B1 receptor agonist, [3H]-des-Arg10-kallidin (-KD) was investigated in smooth muscle cells (SMC) isolated from rabbit mesenteric arteries (RMA). 2. [3H]-des-Arg10-KD specifically bound to interleukin-1 (IL-1)-treated RMA-SMC in a saturable fashion with an equilibrium dissociation constant (KD) of 0.3-0.5 nM. The number of binding sites per cell was 20,000-35,000. Kinins inhibited [3H]-des-Arg10-KD binding to RMA-SMC with an order of potency very similar to that observed in typical B1 specific bioassays: des-Arg9-bradykinin (BK) approximately KD >> BK. Furthermore, the B1 receptor antagonist [Leu8]des-Arg9-BK inhibited [3H]-des-Arg10-KD binding with an IC50 of 43 nM as expected for its effect at B1 receptors. The B2 receptor antagonists, NPC 567 and Hoe 140 only affected [3H]-des-Arg10-KD binding at very high concentrations (IC50 = 0.8 microM and IC50 > 10 microM, respectively). 3. Des-Arg9-BK (B1 agonist) and [Hyp3]Tyr(Me)8-BK (B2 agonist) did not induce prostacyclin (PGI2) production by RMA-SMC. Lipopolysaccharide (LPS) treatment of the cells did not affect the B1 agonist response whereas IL-1 beta treatment produced a 7 fold increase in des-Arg9-BK-stimulated PGI2 production. IL-1 beta also stimulated the response to B2 agonists. 4. Des-Arg9-BK-induced PGI2 secretion in IL-1-primed RMA-SMC was mediated by B1 receptors since it was inhibited by [Leu8]des-Arg9-BK (IC50 = 56-73 nM) but not by Hoe 140. High concentrations of NPC 567 (IC5o = 2.4 micro M) were required to inhibit PGI2 production induced by B1 agonists.5. IL- 1-treated RMA-SMC displayed a 5 fold increase in the number of B1 receptors without modification of the affinity constant, thus establishing a possible relationship between the receptor density and the IL-i-primed B1 response.6. LPS treatment of the cells induced a 4 fold increase in B1 receptor number without modifying PGI2 secretion. This observation suggests that IL-1 but not LPS, in addition to increase in the number of receptors, signals the cell to permit the coupling of B1 receptors to the PLA2/cyclo-oxygenase pathway.
SNAIL: an IP-based wireless sensor network approach to the internet of things (2010)

Recent technological progress has been materializing the Internet of Things (IoT), which is breathing new computational and communicational capability into anything in everyday life. An important step toward the IoT would be to facilitate suitable wireless sensor network technologies based on a verified standard protocol, the Internet Protocol, to support the network of things. An increase in research efforts has led to maturity in this field, yet there seem to be gaps to be filled because of the focus on how to adapt the IP to the space of things. This article introduces the Sensor Networks for an All-IP World (SNAIL) approach to the IoT. The proposed architecture includes a complete IP adaptation method. It also includes four significant network protocols: mobility, web enablement, time synchronization, and security. The feasibility and interoperability of the proposed approach is confirmed by the implementation of SNAIL platforms and tests on a testbed built in the Korea Advanced Research Network.
Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of<i>Bifidobacterium longum</i>CECT 7347 in children with newly diagnosed coeliac disease (2014)

Interactions between the immune system and the intestinal microbiota may play a role in coeliac disease (CD). In the present study, the potential effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed CD were evaluated. A double-blind, randomised, placebo-controlled trial was conducted in thirty-three children who received a capsule containing either B. longum CECT 7347 (10⁹ colony-forming units) or placebo (excipients) daily for 3 months together with a gluten-free diet (GFD). Outcome measures (baseline and post-intervention) included immune phenotype of peripheral blood cells, serum cytokine concentration, faecal secretory IgA (sIgA) content, anthropometric parameters and intestinal microbiota composition. Comparisons between the groups revealed greater height percentile increases (P= 0·048) in the B. longum CECT 7347 group than in the placebo group, as well as decreased peripheral CD3⁺ T lymphocytes (P= 0·004) and slightly reduced TNF-α concentration (P= 0·067). Within-group comparisons of baseline and final values did not reveal any differences in T lymphocytes and cytokines in the placebo group, while decreased CD3⁺ (P =0·013) and human leucocyte antigen (HLA)-DR⁺ T lymphocytes (P =0·029) and slightly reduced TNF-α concentration (P= 0·085) were detected in the B. longum CECT 7347 group. Comparison between the groups showed that the administration of B. longum CECT 7347 reduced the numbers of the Bacteroides fragilis group (P= 0·020) and the content of sIgA in stools (P= 0·011) compared with the administration of placebo. Although this is a first exploratory intervention with limitations, the findings suggest that B. longum CECT 7347 could help improve the health status of CD patients who tend to show alterations in gut microbiota composition and a biased immune response even on a GFD.
Adaptive Document Retrieval for Deep Question Answering (2018)

State-of-the-art systems in deep question answering proceed as follows: (1) an initial document retrieval selects relevant documents, which (2) are then processed by a neural network in order to extract the final answer. Yet the exact interplay between both components is poorly understood, especially concerning the number of candidate documents that should be retrieved. We show that choosing a static number of documents -as used in prior research -suffers from a noiseinformation trade-off and yields suboptimal results. As a remedy, we propose an adaptive document retrieval model. This learns the optimal candidate number for document retrieval, conditional on the size of the corpus and the query. We report extensive experimental results showing that our adaptive approach outperforms state-of-the-art methods on multiple benchmark datasets, as well as in the context of corpora with variable sizes.
Studies on the Malo-Lactic Organisms Isolated from California Wines (1960)

Five types of lactic acid bacteria capable of decomposing malic acid were isolated from California wines. They were recovered from almost all the young dry wines examined. Media for the isolation and growth of these organisms are suggested, and their probable taxonomic grouping is indicated.
Treatment of Spinocerebellar Ataxia with Mesenchymal Stem Cells: A Phase I/IIa Clinical Study (2017)

Ataxia is one of the most devastating symptoms of many neurodegenerative disorders. As of today, there is not any effective treatment to retard its progression. Mesenchymal stem cells (MSCs) have shown promise in treating neurodegenerative diseases. We hereby report the results of a phase I/IIa clinical study conducted in Taiwan to primarily evaluate the safety, tolerability, and, secondarily, the possible efficacy of intravenous administration of allogeneic adipose tissue-derived MSCs from healthy donors. Six patients with spinocerebellar ataxia type 3 and one with multiple system atrophy-cerebellar type were included in this open-label study with intravenous administration of 106 cells/kg body weight. The subjects were closely monitored for 1 year for safety (vital signs, complete blood counts, serum biochemical profiles, and urinalysis) and possible efficacy (scale for assessment and rating of ataxia and sensory organization testing scores, metabolite ratios on the brain magnetic resonance spectroscopy, and brain glucose metabolism of 18-fluorodeoxyglucose using positron emission tomography). No adverse events related to the injection of MSCs during the 1-year follow-up were observed. The intravenous administration of allogeneic MSCs seemed well tolerated. Upon study completion, all patients wished to continue treatment with the allogeneic MSCs. We conclude that allogeneic MSCs given by intravenous injection seems to be safe and tolerable in patients with spinocerebellar ataxia type 3, thus supporting advancement of the clinical development of allogeneic MSCs for the treatment of spinocerebellar ataxias (SCAs) in a randomized, double-blind, placebo-controlled phase II trials.
Yb Fiber Laser Pumped Mid-IR Source Based on Difference Frequency Generation and Its Application to Ammonia Detection (2001)

A Yb fiber laser pumped cw narrow-linewidth tunable mid-IR source based on a difference frequency generation (DFG) in a periodically poled LiNbO3 (PPLN) crystal for trace gas detection was demonstrated. A high power Yb fiber laser and a distributed feedback (DFB) laser diode were used as DFG pump sources. This source generated mid-IR at 3 microns with a powers of ~2.5 microW and a spectral linewidth of less than 30 MHz. A frequency tuning range of 300 GHz (10 cm-1) was obtained by varying the current and temperature of the DFB laser diode. A high-resolution NH3 absorption Doppler-broadened spectrum at 3295.4 cm-1 (3.0345 microns) was obtained at a cell pressure of 27 Pa from which a detection sensitivity of 24 ppm m was estimated.
Icam-1 and acute pancreatitis complicated by acute lung injury. (2009)

One of the most common complications of acute pancreatitis is acute lung injury, during which intercellular adhesion molecule-1 (ICAM-1) plays an important role by participating in leukocyte adhesion and activation as well as by inducing the "cascade effect" of inflammatory mediators, pulmonary microcirculation dysfunction and even acute respiratory distress syndrome, multiple organ failure or death. Although it is generally believed that the modulatory mechanism of ICAM-1 during this process is associated with the activation of nuclear transcription factor kappa B which is mediated by IL-1, IL-6, IL-18 and oxygen free radical, etc., further studies are still required to clarify it. Since the upregulation of ICAM-1 expression in the lung during acute lung injury is one of main pathogeneses, the early detection of the ICAM-1 expression level may contribute to the prevention and treatment of acute lung injury. Moreover, reducing pulmonary ICAM-1 expression levels through treatment with anti-ICAM-1 monoclonal antibody (aICAM-1) and antagonists of the neurokinin 1 receptor, etc., should have a positive effect on protecting the lungs during acute pancreatitis. This review aims to further clarify the relationship between ICAM-1 and acute pancreatitis complicated by acute lung injury, and therefore provides a theoretical basis for the formulation of corresponding therapeutic measures in clinical practice for acute pancreatitis.
Modification of the Double-Disk Test for Detection of <i>Enterobacteriaceae</i> Producing Extended-Spectrum and AmpC β-Lactamases (2003)

Detection of extended-spectrum beta-lactamases (ESBLs) in AmpC-producing Enterobacteriaceae is problematic. A modification of the double-disk test (MDDT) has been developed for successful detection of ESBLs in gram-negative bacilli producing well-characterized beta-lactamases as well as 212 clinical isolates of Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens, and Citrobacter freundii. MDDT accurately differentiated between ESBL producers and derepressed chromosomal AmpC mutants. MDDT provides a cost-effective alternative approach for clinical microbiology laboratories for routine susceptibility testing with simultaneous detection of ESBLs in enterobacteriaceae.
Comparison of non-invasive fetal electrocardiogram to Doppler cardiotocogram during the 1st stage of labor (2010)

This non-invasive fECG presents an alternative, reliable and accurate assessment for fetal well-being during the 1(st) stage of labor.
Scanning-tunneling-microscope observations of Coulomb blockade and oxide polarization in small metal droplets (1989)

The I-V characteristics of two serially coupled small tunnel junctions (about ${10}^{\mathrm{\ensuremath{-}}18}$--${10}^{\mathrm{\ensuremath{-}}19}$ F capacitances) are measured at 4 K. The junctions are formed using a scanning-tunneling microscope to probe a metal droplet deposited on an oxidized metal substrate. Sharply defined Coulumb steps due to single-electron dynamics, oxide polarization, and nonlinear (voltage dependent) tunneling rates are observed. The results show very good quantitative agreement with theoretical calculations based on the semiclassical picture.
Parallel computations on reconfigurable meshes (1993)

The mesh with reconfigurable bus is presented as a model of computation. The reconfigurable mesh captures salient features from a variety of sources, including the CAAPP, CHiP, polymorphic-torus network, and bus automation. It consists of an array of processors interconnected by a reconfigurable bus system that can be used to dynamically obtain various interconnection patterns between the processors. A variety of fundamental data-movement operations for the reconfigurable mesh are introduced. Based on these operations, algorithms that are efficient for solving a variety of problems involving graphs and digitized images are also introduced. The algorithms are asymptotically superior to those previously obtained for the aforementioned reconfigurable architectures, as well as to those previously obtained for the mesh, the mesh with multiple broadcasting, the mesh with multiple buses, the mesh-of-trees, and the pyramid computer. The power of reconfigurability is illustrated by solving some problems, such as the exclusive OR, more efficiently on the reconfigurable mesh than is possible on the programmable random-access memory (PRAM).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>