gebhart/patrepeval huggingface dataset:
Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine (2013)

The oxidation and nitration of unsaturated fatty acids transforms cell membrane and lipoprotein constituents into mediators that regulate signal transduction. The formation of 9-NO2-octadeca-9,11-dienoic acid and 12-NO2-octadeca-9,11-dienoic acid stems from peroxynitrite- and myeloperoxidase-derived nitrogen dioxide reactions as well as secondary to nitrite disproportionation under the acidic conditions of digestion. Broad anti-inflammatory and tissue-protective responses are mediated by nitro-fatty acids. It is now shown that electrophilic fatty acid nitroalkenes are present in the urine of healthy human volunteers (9.9 ± 4.0 pmol/mg creatinine); along with electrophilic 16- and 14-carbon nitroalkenyl β-oxidation metabolites. High resolution mass determinations and coelution with isotopically-labeled metabolites support renal excretion of cysteine-nitroalkene conjugates. These products of Michael addition are in equilibrium with the free nitroalkene pool in urine and are displaced by thiol reaction with mercury chloride. This reaction increases the level of free nitroalkene fraction >10-fold and displays a K(D) of 7.5 × 10(-6) M. In aggregate, the data indicates that formation of Michael adducts by electrophilic fatty acids is favored under biological conditions and that reversal of these addition reactions is critical for detecting both parent nitroalkenes and their metabolites. The measurement of this class of mediators can constitute a sensitive noninvasive index of metabolic and inflammatory status.
Compensation for I/Q Imbalances and Bias Deviation of the Mach–Zehnder Modulators in Direct-Detected Optical OFDM Systems (2008)

We demonstrate an equalization technique to simultaneously compensate for the fiber chromatic dispersion and the distortions induced by the in-phase/quadrature-phase (I/Q) imbalances and bias deviation in the Mach-Zehnder modulators (MZMs). With this technique, the requirement for the monitoring circuits at the transmitter could be relaxed or even eliminated, and thus simplifies the system design and reduces the system cost. The system exhibits a good performance with our proposal over a broad range of imbalances and bias deviation in the MZM. With deliberately introducing I/Q imbalances and bias deviation, we have observed a 2- and 4-dB optical signal-to-noise ratio improvement, for the back-to-back and 800 km of uncompensated standard single-mode fiber transmission, respectively, with our proposed scheme.
A Primer on Zero Knowledge Protocols (2002)

It is a common weakness among traditional communication protocols to be vulnerable to impersonation attacks. Every time this sort of protocol is executed, the system degradates because of the threat of an eavesdropper listening in on the communication. Zero Knowledge Protocols, presented by Goldwasser, Micali, and Rackoff, are an improvement on these situations. The objective is to obtain a system in which it is possible for a prover to convince a verifier of his knowledge of a certain secret without disclosing any information except the validity of his claim. This article will cover the basics of zero knowledge systems, explaining the main properties and characteristics. A series of examples, in growing level of difficulty, will also be presented, to see the main areas of application of such protocols. 1
Curvature Effects in Alloy Dissolution (1993)

An elemental metal can dissolve at kink sites at low everpotentials producing no new interfacial area. When an ideal solid solution alloy undergoes selective dissolution, this situation is not possible owing to atomic‐scale disorder. Dissolution of the less noble constituent can proceed only by injection of regions of negative curvature into the solid surface, which increases the interfacial area. We present a thermodynamic analysis which accounts for these capillary effects in alloy dissolution. The phenomenon of the critical potential for macroscopic selective dissolution is analyzed in terms of a kinetic roughening transition. This transition results from a competition between curvature‐dependent dissolution and surface diffusion. An expression for the critical potential as a function of alloy composition is developed. The dealloying threshold corresponds to a critical composition on the line of critical potentials defining the roughening transition.
Gene conversion in Escherichia coli: the recF pathway for resolution of heteroduplex DNA (1989)

The independent repair of mismatched nucleotides present in heteroduplex DNA has been used to explain gene conversion and map expansion after general genetic recombination. We have constructed and purified heteroduplex plasmid DNAs that contain heteroallelic 10-base-pair insertion-deletion mismatches. These DNA substrates are similar in structure to the heteroduplex DNA intermediates that have been proposed to be produced during the genetic recombination of plasmids. These DNA substrates were transformed into wild-type and mutant Escherichia coli strains, and the fate of the heteroduplex DNA was determined by both restriction mapping and genetic tests. Independent repair events that yielded a wild-type Tetr gene were observed at a frequency of approximately 1% in both wild-type and recB recC sbcB mutant E. coli strains. The independent repair of small insertion-deletion-type mismatches separated by 1,243 base pairs was found to be reduced by recF, recJ, and ssb single mutations in an otherwise wild-type genetic background and reduced by recF, recJ, and recO mutations in a recB recC sbcB genetic background (the ssb mutation was not tested in the latter background). Independent repair of small insertion-deletion-type mismatched nucleotides that were as close as 312 nucleotides apart was observed. There was no apparent bias in favor of the insertion or deletion of mutant sequences.
PanDoRA: a large-scale two-way statistical machine translation system for hand-held devices (2007)

The statistical machine translation (SMT) approach has taken a lead place in the field of Machine Translation for its better translation quality and lower cost in training compared to other approaches. However, due to the high demand of computing resources, an SMT system can not be directly run on hand-held devices. Most existing hand-held translation systems are either interlingua-based, which require non-trivial human efforts to write grammar rules, or using the client/server architecture, which are constrained by the availability of wireless connections. In this paper we present PanDoRA, a two-way phrase-based statistical machine translation system for stand-alone hand-held devices. Powered by special designs such as integerized computation and compact data structure, PanDoRA can translate dialogue speech on off-the-shelf PDAs in real time. PanDoRA uses 64K words vocabulary and millions of phrase pairs for each translation directions. To our knowledge, PanDoRA is the first large-scale SMT system with build-in reordering models running on hand-held devices. We have successfully developed several speech-to-speech translation systems using PanDoRA and our experiments show that PanDoRA&apos;s translation quality is comparable to that of the state-of-the-art phrase-based statistical machine translation systems such as Pharaoh and STTK.
Aerosol Deposition of Ceramic Thick Films at Room Temperature: Densification Mechanism of Ceramic Layers (2006)

A novel method for depositing ceramic thick films by aerosol deposition (AD) is presented. Submicron ceramics particles are accelerated by gas flow up to 100–500 m/s and then impacted on a substrate, to form a dense, uniform and hard ceramic layer at room temperature. However, actual deposition mechanism has not been clarified yet. To clarify densification mechanism during AD, a mixed aerosol of α‐Al 2 O 3 and Pb(Zr, Ti)O 3 powder was deposited to form a composite layer in this study. The cross‐section of the layer was observed by HR‐TEM to investigate the densification and bonding mechanism of ceramic particles. As a result, a plastic deformation of starting ceramic particles at room temperature was observed.
Nature, Function and Capability: Aristotle on Political Distribution (1987)

Distribution, Political science, Quality of life
Defective epithelial ion transport in cystic fibrosis. (1989)

In America, cystic fibrosis (CF) is the most common fatal inherited disease. In the past few years new concepts have evolved regarding the etiology of CF, changing from an almost universal acceptance of the abnormality as a disease of abnormal mucus production to that of a disease of abnormal fluid and electrolyte transport. Although mucus production is increased, this probably occurs as a secondary defense or protection against more primary disturbances in electrolyte transport brought on by a defect in Cl- permeability that affects both fluid absorption and fluid secretion. Here I review the progress that has been made and some of the puzzles uncovered in recent investigations of electrolyte transport in secretory and absorptive processes in cystic fibrosis.
Downlink beamforming with delayed channel estimates under total power, element power and equivalent isotropic radiated power (EIRP) constraints (2002)

A WLAN-type scenario where a base-station (access point) equipped with multiple antennas is transmitting and a mobile with only a single antenna is receiving, is considered. Three approaches are investigated: grid-of-beams (GOB), maximal-ratio (MR) and equal-gain (EG), each with one of the following constraints 1) total transmit power over all antenna elements, 2) maximum power on any antenna element 3) equivalent isotropic radiated power (EIRP). The median diversity gain for the MR approach is estimated to be 14.8 dB, 10.6 dB, and 11.4 dB using constraint 1-3, respectively at 5.2 GHz in a modern university building at 5-50 meter range. For GOB corresponding numbers are 9.4 dB, 9.4 dB, 2.3 dB and for EG 13.9 dB, 13.9 dB, 10.3 dB, respectively. These results are virtually independent of delay between channel estimation and use of the same estimate, when the delay is less than 130 ms. This result is obtained although there were people moving in the environment. The diversity gain under the EIRP constraint is encouraging and shows that coverage improvements are possible even under EIRP limitations.
Monitoring and Diagnostics of PV Plants by a Wireless Self-Powered Sensor for Individual Panels (2015)

In this paper, an innovative sensor suited to perform real-time measurements of operating voltage and current, open-circuit voltage, and short-circuit current of string-connected photovoltaic (PV) panels is presented. An effective disconnection system ensures that the sensor does not affect the behavior of the string during the measurement phase and offers many benefits like the automatic detection of bypass events; moreover, the sensor does not require additional cables thanks to a wireless communication and a power supply section based on energy harvesting. An extensive experimental campaign is performed to prove the reliability and usefulness of the sensor for continuous monitoring of PV plants. The capability to detect faults and accurately localize malfunctioning panels in a PV string is highlighted.
Circadian-Associated Rice Pseudo Response Regulators (<i>Os</i>PRRs): Insight into the Control of Flowering Time (2005)

A small family of plant proteins, designated PSEUDO RESPONSE REGULATORS (PRRs), is crucial for a better understanding of the molecular link between circadian rhythm and photoperiodic control of flowering time in the dicotyledonous model plant Arabidopsis thaliana. Recently, we showed that the monocotyledonous model plant Oryza sativa also has homologous members of the OsPRR family (Oryza sativa PRR). In the previous experiments with rice, we mainly characterized a japonica variety (Nipponbare). By employing an indica variety (Kasalath), in this study we further characterized OsPRRs with reference to the photoperiod sensitivity Hd (Heading date) QTL (quantitative trait loci) implicated in the control of flowering time in rice. The circadian-controlled and sequential expression profiles of the five OsPRR genes were observed not only for Nipponbare but also for Kasalath. Then each of these OsPRR genes was mapped on the rice chromosomes. Among these OsPRR genes, OsPRR37 was mapped very closely to Hd2-QTL, which was identified as the major locus that enhances the photoperiod sensitivity of flowering in Nipponbare. Furthermore, we found that Kasalath has a severe mutational lesion in the OsPRR37 coding sequence.
Annexin A2 tetramer activates human and murine macrophages through TLR4 (2009)

Annexins are a large family of intracellular phospholipid-binding proteins, yet several extracellular roles have been identified. Specifically, annexin A2, found in a heterotetrameric complex with S100A10, not only serves as a key extracellular binding partner for pathogens and host proteins alike, but also can be shed or secreted. We reported previously that soluble annexin A2 tetramer (A2t) activates human monocyte-derived macrophages (MDM), resulting in secretion of inflammatory mediators and enhanced phagocytosis. Although a receptor for A2t has been cloned from bone marrow stromal cells, data contained in this study demonstrate that it is dispensable for A2t-dependent activation of MDM. Furthermore, A2t activates wild-type murine bone marrow-derived macrophages, whereas macrophages from myeloid differentiation factor 88-deficient mice display a blunted response, suggesting a role for Toll-like receptor (TLR) signaling. Small interfering RNA knockdown of TLR4 in human MDM reduced the response to A2t, blocking antibodies against TLR4 (but not TLR2) blocked activation altogether, and bone marrow-derived macrophages from TLR4(-/-) mice were refractory to A2t. These data demonstrate that the modulation of macrophage function by A2t is mediated through TLR4, suggesting a previously unknown, but important role for this stress-sensitive protein in the detection of danger to the host, whether from injury or invasion.
ChemInform Abstract: TECHNICAL PROCEDURES FOR THE SYNTHESIS OF CAROTENOIDS AND RELATED COMPOUNDS FROM 6‐OXOISOPHORONE. V. SYNTHESIS OF ASTACENE (1982)

Abstract Durch Kondensation des Ketons (I) mit dem Enin (II) wird der Alkohol (III) und analog der isomere Alkohol (IV) dargestellt.
Laser-Guided Atoms in Hollow-Core Optical Fibers (1995)

We have used optical forces to guide atoms through hollow-core optical fibers. Laser light is launched into the hollow region of a glass capillary fiber and guided by grazing-incidence reflection from the walls. When the laser is detuned 1--30 GHz red of the Rb D2 resonance lines, dipole forces attract atoms to the high-intensity region along the axis and guide them through the fiber. We show that atoms may be guided around bends in the fiber and that in initial experiments the atoms experience up to 18 reflections from the potential walls with minimal loss.
Magnetic Susceptibility Effects of Trabecular Bone on Magnetic Resonance Imaging of Bone Marrow (1990)

High-field spectroscopic studies at 5.88 tesla (T) indicate significant T2* shortening of water in suspensions of powdered bone, interpreted to be a result of magnetic susceptibility differences between bone particles and water. The authors investigated the effects of magnetic susceptibility differences between trabecular bone and water on magnetic resonance (MR) images at 0.6 T. The phantom was constructed of macerated intact trabecular human bone immersed in water. Although susceptibility-induced magnetic field inhomogeneities were detected by spectral line broadening by using an asymmetric spin-echo technique, the results show only a modest T2* shortening at this field strength. As expected, no T1 effect of trabecular bone was observed. Although susceptibility effects of trabecular bone may have a small impact on the signal intensity of MR images of bone marrow at midfield strength, the observed field strength dependence of these effects would predict significant susceptibility effects on clinical images at higher field strength.
Silica−Titania-Based Organic−Inorganic Hybrid Materials for Photovoltaic Applications (2006)

Silica−titania-based organic−inorganic hybrid materials (OIHMs) containing covalently bonded organic chromophores with photosensitization ability were developed. The presence of the Ti−O−Si linkage in these OIHMs was established by infrared spectroscopy. Photocurrent and photovoltage were generated upon irradiation of these OIHM films on an indium tin oxide (ITO) glass or nanocrystalline TiO2 surface. The photovoltaic properties depend on the relative molar fractions of silica and titania in the OIHM films. The OIHMs thus prepared can serve as anchoring matrixes for associating the chromophores with nanocrystalline TiO2 surfaces and can be used as active layers in photovoltaic devices. Control experiments using a blending protocol suggest that covalent bonding between the chromophores and the silica−titania hybrid networks is essential to enhancing the performance of photovoltaic devices.
Crystallography at high pressure (2010)

The International Union of Crystallography (IUCr) Meeting on “Advanced Crystallography at High Pressure” was held at the Harbin Institute of Technology (HIT), Harbin, China during 19–22 July 2009. ...
Cladribine and progressive MS (2000)

No significant treatment effects were found for cladribine in terms of changes in EDSS or SNRS scores. Both doses of cladribine produced and sustained significant reductions in the presence, number, and volume of gadolinium-enhanced T1 brain lesions on MRI, and cladribine 2.1 mg/kg reduced the accumulation of T2 lesion load. Cladribine at doses up to 2.1 mg/kg was generally safe and well tolerated.
Basic properties of a liquidt in anode solid oxide fuel cell (2010)

An unconventional high temperature fuel cell system, the liquidt in anode solid oxide fuel cell(LTA-SOFC), is discussed. A thermodynamic analysis of a solid oxide fuel cell with a liquid metal anode is developed. Pertinent thermo chemical and thermo physical properties of liquid tin in particular are detailed. An experimental setup for analysis of LTA-SOFC anode kinetics is described, and data for a planar cell under hydrogen indicated an effective oxygen diffusion coefficient of 5.3×10−5 cm2 s−1 at 800 ◦C and 8.9×10−5 cm2 s−1 at 900 ◦C. This value is similar to previously reported literature values for liquid tin. The oxygen conductivity through the tin, calculated from measured diffusion coefficients and theoretical oxygen solubility limits, is found to be on the same order of thatofyttria-stabilizedzirconia(YSZ), a traditional SOFC electrolyte material. As such,the ohmicloss due to oxygen transport through the tin layer must be considered in practical system cell design since the tin layer will usually be at least as thick as the electrolyte.
Vibration analysis for diagnostic testing of circuit-breakers (1996)

In order to assess the feasibility of vibration analysis for the diagnostic testing of high-voltage circuit breakers, a comprehensive field test program has been carried out. Vibration patterns from 31 breakers (93 identical single-phase units) have been acquired, compared and analyzed. The breakers were assumed to be in good condition with no known irregularities at the time of testing. However, several serious faults, including an incipient rupture of the contact plug shaft, an incorrectly assembled crank, and major lubrication problems were disclosed. Thus, this "blind test" performed under realistic conditions on circuit breakers in normal service demonstrates that vibration analysis can be a reliable and suitable tool for noninvasive diagnostic testing.
Idrottsforskaren mer efterfrågad än någonsin! : att mäta fysisk aktivitet - ett bra exempel (2001)

Idrottsforskaren mer efterfragad an nagonsin! : att mata fysisk aktivitet - ett bra exempel
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission (2017)

G protein-coupled receptors (GPCRs) are considered to function primarily at the plasma membrane, where they interact with extracellular ligands and couple to G proteins that transmit intracellular signals. Consequently, therapeutic drugs are designed to target GPCRs at the plasma membrane. Activated GPCRs undergo clathrin-dependent endocytosis. Whether GPCRs in endosomes control pathophysiological processes in vivo and are therapeutic targets remains uncertain. We investigated the contribution of endosomal signaling of the calcitonin receptor-like receptor (CLR) to pain transmission. Calcitonin gene-related peptide (CGRP) stimulated CLR endocytosis and activated protein kinase C (PKC) in the cytosol and extracellular signal regulated kinase (ERK) in the cytosol and nucleus. Inhibitors of clathrin and dynamin prevented CLR endocytosis and activation of cytosolic PKC and nuclear ERK, which derive from endosomal CLR. A cholestanol-conjugated antagonist, CGRP<sub>8-37</sub>, accumulated in CLR-containing endosomes and selectively inhibited CLR signaling in endosomes. CGRP caused sustained excitation of neurons in slices of rat spinal cord. Inhibitors of dynamin, ERK, and PKC suppressed persistent neuronal excitation. CGRP<sub>8-37</sub>-cholestanol, but not unconjugated CGRP<sub>8-37</sub>, prevented sustained neuronal excitation. When injected intrathecally to mice, CGRP<sub>8-37</sub>-cholestanol inhibited nociceptive responses to intraplantar injection of capsaicin, formalin, or complete Freund's adjuvant more effectively than unconjugated CGRP<sub>8-37</sub> Our results show that CLR signals from endosomes to control pain transmission and identify CLR in endosomes as a therapeutic target for pain. Thus, GPCRs function not only at the plasma membrane but also in endosomes to control complex processes in vivo. Endosomal GPCRs are a drug target that deserve further attention.
Simultaneous localization, mapping and deblurring (2011)

Handling motion blur is one of important issues in visual SLAM. For a fast-moving camera, motion blur is an unavoidable effect and it can degrade the results of localization and reconstruction severely. In this paper, we present a unified algorithm to handle motion blur for visual SLAM, including the blur-robust data association method and the fast deblurring method. In our framework, camera motion and 3-D point structures are reconstructed by SLAM, and the information from SLAM makes the estimation of motion blur quite easy and effective. Reversely, estimating motion blur enables robust data association and drift-free localization of SLAM with blurred images. The blurred images are recovered by fast deconvolution using SLAM data, and more features are extracted and registered to the map so that the SLAM procedure can be continued even with the blurred images. In this way, visual SLAM and deblurring are solved simultaneously, and improve each other's results significantly.
The regulation of human globin gene switching (1993)

This paper describes the mechanism of regulation of the human beta-globin on the basis of a number of natural mutations and experiments in transgenic mice. From these data we conclude that this multigene locus is regulated at a number of different levels involving specific interactions between the Locus Control Region (LCR) and the individual genes. Most important is the action of stage specific transcription factors acting on sequences immediately flanking the genes. In addition, specificity is obtained through specific interaction of the genes with the LCR and through competition of the genes for interaction with the LCR.