gebhart/patrepeval huggingface dataset:
Branched Fluoropolymer−Si Hybrids via Surface-Initiated ATRP of Pentafluorostyrene on Hydrogen-Terminated Si(100) Surfaces (2004)

Linear, branched, and arborescent fluoropolymer-Si hybrids were prepared via surface-initiated atom transfer radical polymerization (ATRP) from the 4-vinylbenzyl chloride (VBC) inimer and ClSO(3)H-modified VBC that were immobilized on hydrogen-terminated Si(100), or Si-H, surfaces. The simple approach of UV-induced coupling of VBC with the Si-H surface provided a stable, Si-C bonded monolayer of "monofunctional" ATRP initiators (the Si-VBC surface). The aromatic rings of the Si-VBC surface were then sulfonated by ClSO(3)H to introduce sulfonyl chloride (-SO(2)Cl) groups and to give rise to a monolayer of "bifunctional" ATRP initiators. Kinetics study indicated that the chain growth of poly(pentafluorostyrene) from the functionalized silicon surfaces was consistent with a "controlled" or "living" process. The chemical composition and functionality of the silicon surface were tailored by the well-defined linear and branched fluoropolymer brushes. Atomic force microscopy images revealed that the surface-initiated ATRP of pentafluorostyrene (PFS) had proceeded uniformly on the Si-VBC surface to give rise to a dense and molecularly flat surface coverage of the linear brushes. The uniformity of surfaces with branched brushes was controlled by varying the feed ratio of the monomer and inimer (VBC in the present case). The living chain ends on the functionalized silicon surfaces were used as the macroinitiators for the synthesis of diblock copolymer brushes, consisting of the PFS and methyl methacrylate polymer blocks.
Engineering Design of Tough Ceramic Matrix Composites for Turbine Components (1991)

This paper provides a review of the material design concepts for the toughening of ceramic matrix composites by three-dimensional fiber architecture. To establish a communication link between the structural and the materials engineers, an integrated design methodology is presented with an example. Through a Fabric Geometry Model (FGM), the contribution of three-dimensional fiber architecture is translated into a stiffness matrix for finite element structural analysis. With the feedback from the structural analysis, this design methodology provides an effective means to screen reinforcement materials systems for three-dimensional fabric-reinforced composite components.
Nocardiopsis quinghaiensis sp. nov., isolated from saline soil in China (2008)

A previously unknown Gram-positive, obligately aerobic actinomycete, YIM 28A4(T), was isolated from a sample of saline soil collected from the Qaidam Basin in Qinghai Province, north-west China, and was investigated using a polyphasic taxonomic approach. The strain grew well on most of the media tested, producing white to pale-yellow substrate mycelium, white aerial mycelium and straight to flexuous hyphae. The substrate mycelium was well developed and fragmented with age; the aerial mycelium produced long, straight spore chains. The spore chains were composed of non-motile, smooth-surfaced, rod-shaped spores. No diffusible pigments were produced on any of the media tested. The strain grew in the presence of 0-10 % (w/v) NaCl and at pH 6.0-8.0, with optimum growth occurring at 3 % (w/v) NaCl and pH 7.0. It grew at 10-37 degrees C, the optimum growth temperature being 28 degrees C. Whole-cell hydrolysates of strain YIM 28A4(T) contained meso-diaminopimelic acid and no diagnostic sugars. The predominant phospholipids were phosphatidylcholine, phosphatidylglycerol and diphosphatidylglycerol. The predominant menaquinones were MK-10, MK-10(H(2)), MK-11 and MK-11(H(2)). The major cellular fatty acids were iso-C(16 : 0), anteiso-C(15 : 0) and anteiso-C(17 : 0). The DNA G+C content was 67.1 mol%. The morphological and chemotaxonomic characteristics of the isolate matched those described for Nocardiopsis species. A phylogenetic analysis based on 16S rRNA gene sequence comparisons confirmed that strain YIM 28A4(T) was a member of the genus Nocardiopsis and most closely related to the type strains Nocardiopsis aegyptia DSM 44442(T) and Nocardiopsis halotolerans DSM 44410(T), showing 98.1 and 97.8 % 16S rRNA gene sequence similarity, respectively. Strain YIM 28A4(T) can be differentiated from these type strains by using phenotypic, phylogenetic and DNA-DNA hybridization data. On the basis of the polyphasic evidence, strain YIM 28A4(T) represents a novel species of the genus Nocardiopsis, for which the name Nocardiopsis quinghaiensis sp. nov. is proposed. The type strain is YIM 28A4(T) (=DSM 44739(T) =CGMCC 4.3494(T)).
Optimization on MOS-Triggered SCR Structures for On-Chip ESD Protection (2009)

MOS-triggered silicon-controlled rectifier (SCR) devices have been reported to achieve efficient on-chip electrostatic discharge (ESD) protection in deep-submicrometer CMOS technology. The channel length of the embedded MOS transistor in the MOS-triggered SCR device dominates the trigger mechanism and current distribution to govern the trigger voltage, holding voltage, on resistance, second breakdown current, and ESD robustness of the MOS-triggered SCR device. The embedded MOS transistor in the MOS-triggered SCR device should be optimized to achieve the most efficient ESD protection in advanced CMOS technology. In addition, the layout style of the embedded MOS transistor can be adjusted to improve the MOS-triggered SCR device for ESD protection.
The generalized perceived input point model and how to double touch accuracy by extracting fingerprints (2010)

It is generally assumed that touch input cannot be accurate because of the fat finger problem, i.e., the softness of the fingertip combined with the occlusion of the target by the finger. In this paper, we show that this is not the case. We base our argument on a new model of touch inaccuracy. Our model is not based on the fat finger problem, but on the perceived input point model. In its published form, this model states that touch screens report touch location at an offset from the intended target. We generalize this model so that it represents offsets for individual finger postures and users. We thereby switch from the traditional 2D model of touch to a model that considers touch a phenomenon in 3-space. We report a user study, in which the generalized model explained 67% of the touch inaccuracy that was previously attributed to the fat finger problem.
Formulating technology for rigid cellular PVC sheet (1992)

Abstract Rigid vinyl can be considered as a highly versatile thermoplastic, finding its way into many different applications. Vinyl's capacity for innovation is virtually limitless, thanks in part to advances in formulation additives, which have enlarged vinyl's processing and end‐use performance capabilities. The importance of formulating is particularly evident in rigid cellular PVC, which can be extruded into a variety of shapes, such as profile, pipe, and sheet, all made with less PVC than their solid counterparts. The sheet application can be especially challenging, and it has been made the subject of this paper. The various types of extrusion processes, formulations, and uses for rigid cellular PVC sheet that are found in North America and Europe are compared. The effect of certain types of formulation ingredients on sheet density, surface, and impact strength is described. Reference is made to coextrusion of solid/cellular PVC layers as an economically feasible approach to handling industrial regrind PVC.
Identification of a Hemin Utilization Protein of <i>Moraxella catarrhalis</i> (HumA) (2004)

Moraxella catarrhalis is a major cause of acute otitis media in young children and has also been implicated as an important cause of exacerbations in adults with underlying pulmonary disease. Due to the considerable level of antibiotic resistance and the high degree of carriage rates in young children, it is likely that the incidence of M. catarrhalis infections will continue to rise. M. catarrhalis is a strict human respiratory pathogen, and this bacterium uses both transferrin and lactoferrin receptors to fulfill the essential iron requirement for survival in vivo. However, these are the only described iron acquisition systems for this organism. In this report we have demonstrated that M. catarrhalis can also utilize hemin as a sole source of iron for growth. In addition, we have identified and characterized an outer membrane protein with homology (26 to 28% similarity) to other known hemin binding and uptake proteins in related gram-negative organisms (i.e., Bordetella and Yersinia spp.). This newly described M. catarrhalis protein, termed HumA, is capable of directly binding to hemin coupled to a solid-phase matrix. M. catarrhalis HumA expressed on the surface of an Escherichia coli hemA-deficient strain (K-12 EB53) is fully capable of complementing the defect and thus restoring the ability of this strain to grow in the presence of hemin. When M. catarrhalis is grown in the presence of hemin, HumA expression is clearly increased as shown by Western blotting with polyclonal antiserum developed against a HumA peptide. In addition, growth analyses revealed that a HumA-deficient mutant of M. catarrhalis (7169::humA) is restricted for growth in the presence of hemin as the sole iron source compared to the wild-type strain. We conclude that HumA is an essential component of a hemin uptake and utilization system previously undescribed for M. catarrhalis, thus providing another mechanism of iron acquisition that may facilitate persistent colonization of the mucosal surface.
Antineoplastic agents. 1. N-Protected vinyl, 1,2-dihaloethyl, and cyanomethyl esters of phenylalanine (1977)

A series of N-protected vinyl, 1,2-dihaloethyl, and cyanomethyl esters of phenylalanine was synthesized and these compounds were evaluated for antitumor activity against the growth of Ehrlich ascites carcinoma in CF1 male mice (33 mg/kg/day), Walker 256 carcinosarcoma in Sprague-Dawley male rats (2.5 mg/kg/day), and P388 lymphocytic leukemia in DBA/2 mice (20 mg/kg/day). Structure-activity relationships were evaluated and acute toxicity studies (LD50 determinations) in male CF1 mice were also carried out on selected compounds. Carbobenzoxy-L0phenylalanine vinyl ester (5), N-carbobenzoxy-L-phenylalanine 1,2-dibromoethyl ester (12), and N-carbobenzoxy-L-phenylalanine cyanomethyl ester (8) were found to be very potent inhibitors of Ehrlich ascites tumor growth at nontoxic doses cited above. Compounds 5 and 12 also tripled survival time in the Walker 256 system. LD50 values for compounds 5, 12, and 8 were greater than 2000 mg/kg (greater than 6.15 mmol/kg), 74 mg/kg (0.15 mmol/kg), and 150 mg/kg (0.44 mmol/kg), respectively.
Image-based techniques in a hybrid collision detector (2003)

Most collision detection methods developed so far are based on geometrical object-space interference tests. While this remains the basic mode of investigation for geometric algorithms, the requirements for interactive rates and complex geometry predominate in commercial applications. In this article, we propose a new mode of collision detection based on an image-space approach. This approach breaks the object-space collision detection bottleneck by distributing the computational load onto the hardware graphics pipeline. The image-space approach, in conjunction with efficient bounding-box strategies in the object-space, has the potential to handle complex object interactions at interactive rates.
Air‐Oxidation of Starch Using Quinquevalent Vanadium as Catalyst (1971)

Abstract Air‐oxidation of corn starch in the presence of ammonium meta vanadate at 35–40°C and pH 9 has been studied. The resulting oxidized starch contained more carbonyl but less carboxyl as compared to an industrial oxidized starch. However, the presence of undesirable amounts of the catalyst imparted extremely high viscosity to the oxidized starch. The ultraviolet irradiation was found to have a pronounced effect on the air oxidation of starch in the presence of ammonium meta vanadate. Increased carboxyl content was observed in the UV light catalyzed oxidized starch.
Synthesis of poly(2,5-dialkoxyphenylene) (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of poly(2,5-dialkoxyphenylene)Mitsuru Ueda, Tetsuya Abe, and Hiroshi AwanoCite this: Macromolecules 1992, 25, 20, 5125–5130Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ma00046a002https://doi.org/10.1021/ma00046a002research-articleACS PublicationsRequest reuse permissionsArticle Views293Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Integration of Geochemical, Mud-Gas, and Downhole-Fluid Analyses for the Assessment of Compositional Grading—Case Studies (2007)

Abstract Identifying compartmentalization, quantifying connectivity, and assessing the presence of compositional grading are critically important to reservoir management, particularly in deepwater projects where uncertainties are large and mistakes are costly. Compositional grading has been known for over 50 years, but the topic received little attention until the 1980's when sufficiently advanced analytical methods became available to assess the phenomenon. Individually, geochemistry, downhole fluid, and mud gas analyses have provided valuable insights into compositional grading, but each analytical method relies on different fluid traits and has different implications. When these analytic methods are systematically combined and consistently applied, the synergy delivers a much more accurate and robust picture of the reservoir and the fluids therein. In this paper, we review two case studies in which we have combined multiple techniques for the assessment of compositional grading in different settings. We demonstrate that new technologies combined with real-time monitoring and control and a more integrated evaluation approach produce a more robust interpretation of the fluids and yield insights into reservoir architecture.
Treatment of massive hypertriglyceridemia resistant to PUFA and fibrates: A possible role for the coenzyme Q10? (2005)

Even though the mechanism of action through which the effects were obtained is yet to be elucidated, adding CoQ10 to fenofibrate could improve the drug's efficacy in MHTG patients not responding to fenofibrate alone.
Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. (2003)

The aim of our study was to assess the relationship between colorectal tumor responsiveness to irinotecan and microsatellite instability (MSI), a feature of colorectal tumors with DNA mismatch repair defect. Seventy-two patients with metastatic colorectal cancer were included in our retrospective study. A complete response to irinotecan was observed in 1 patient and a partial response in 10 patients, whereas 61 patients did not respond to this treatment. We analyzed the protein expression of hMLH1, hMSH2, and BAX by immunohistochemistry, determined the MSI phenotype, and looked for mutations in the coding repeats located in the transforming growth factor beta-RII, BAX, hMSH3, and hMSH6 genes. All 44 tumors analyzed expressed detectable levels of hMLH1; 1 tumor lacked hMSH2 staining, whereas 4 tumors showed a marked decrease in BAX expression. A better response to irinotecan was observed in the patients whose tumors have lost BAX expression (P < 0.001). Among the 7 tumors that displayed a MSI-H phenotype, 4 responded to irinotecan, whereas only 7 of the 65 MSI-L/ microsatellite stable tumors did (P = 0.009). Seven of the 72 tumors had inactivating mutations in the coding repeats of the target genes. Three tumors displayed a mutation in the poly-A10 tract of the transforming growth factor beta-RII gene, associated with a 1-bp deletion in the poly-A8 tract of hMSH3 in one tumor and with a 1-bp deletion in the poly-G8 tract of BAX in another. Four tumors displayed mutations in the poly-G8 repeat of BAX, whereas 2 mutations in hMSH6 and hMSH3 were characterized. Among the 7 tumors with mutations in these target genes, 5 responded to irinotecan, whereas only 6 of the other 65 tumors did (P < 0.001), indicating that MSI-driven inactivation of target genes modifies tumor chemosensitivity. Our observations allowed us to define the first useful predictive criteria for irinotecan response in patients with colorectal cancer.
Improving branch prediction accuracy by reducing pattern history table interference (2002)

Today's deeply pipelined, superscalar processors rely on accurate branch prediction in order to approach their performance potential. Branch mispredictions result in a flushing of the speculative information in the pipeline, thus limiting the amount of useful work that can be done. The 2-level branch predictors have been shown to achieve high prediction accuracy. However, it has also been shown that there is a high degree of pattern history table interference in 2-level branch predictors and that the interference generally has a negative effect on the prediction accuracy. This paper introduces a method for reducing the pattern history table interference by dynamically identifying some easily predictable branches and inhibiting the pattern history table update for these branches. We show how this technique reduces pattern history table interference for two versions of the 2-level branch predictor and that this significantly improves branch prediction accuracy for the SPEC 95 benchmarks. In particular, we eliminate up to 30% of the mispredictions for the gcc benchmark.
Autologous peripheral hematopoietic stem cell transplantation restores hematopoietic function following marrow ablative therapy (1988)

From ten patients with advanced malignant disease involving the bone marrow, autologous hematopoietic stem cells were collected from the peripheral blood during eight four-hour pheresis procedures and cryopreserved. No manipulations to increase the number of stem cells circulating in the blood were used during the collections. Following marrow ablative chemotherapy or chemoradiotherapy, the autologous cells were thawed and infused intravenously (IV). WBCs reappeared in the circulation at a median of eight days (range seven to 11 days) after stem cell infusion. Two patients died early, whereas the other eight reached normal numbers of circulating granulocytes that have persisted for up to greater than 20 months. These eight patients became independent of RBC transfusions (hemoglobin concentration greater than 10 g/dL) at a median of 27 days (range 11 to 58 days) after transplantation. One patient received platelet transfusions for counts less than 50 x 109)/L, one patient developed a clinical picture of idiopathic thrombocytopenic purpura, and six patients maintained a platelet count greater than 20 x 10(9)/L at a median of 23 days (range 14 to 25 days) following stem cell infusion. This technique allows patients ineligible for autologous bone marrow transplantation due to unacceptable anesthetic risks, prior pelvic irradiation, or bone marrow metastases to receive marrow ablative therapy.
Development of an Aptamer Beacon for Detection of Interferon-Gamma (2010)

Traditional antibody-based affinity sensing strategies employ multiple reagents and washing steps and are unsuitable for real-time detection of analyte binding. Aptamers, on the other hand, may be designed to monitor binding events directly, in real-time, without the need for secondary labels. The goal of the present study was to design an aptamer beacon for fluorescence resonance energy transfer (FRET)-based detection of interferon-gamma (IFN-gamma)--an important inflammatory cytokine. Variants of DNA aptamer modified with biotin moieties and spacers were immobilized on avidin-coated surfaces and characterized by surface plasmon resonance (SPR). The SPR studies showed that immobilization of aptamer via the 3' end resulted in the best binding IFN-gamma (K(d) = 3.44 nM). This optimal aptamer variant was then used to construct a beacon by hybridizing fluorophore-labeled aptamer with an antisense oligonucleotide strand carrying a quencher. SPR studies revealed that IFN-gamma binding with an aptamer beacon occurred within 15 min of analyte introduction--suggesting dynamic replacement of the quencher-complementary strand by IFN-gamma molecules. To further highlight biosensing applications, aptamer beacon molecules were immobilized inside microfluidic channels and challenged with varying concentration of analyte. Fluorescence microscopy revealed low fluorescence in the absence of analyte and high fluorescence after introduction of IFN-gamma. Importantly, unlike traditional antibody-based immunoassays, the signal was observed directly upon binding of analyte without the need for multiple washing steps. The surface immobilized aptamer beacon had a linear range from 5 to 100 nM and a lower limit of detection of 5 nM IFN-gamma. In conclusion, we designed a FRET-based aptamer beacon for monitoring of an inflammatory cytokine-IFN-gamma. In the future, this biosensing strategy will be employed to monitor dynamics of cytokine production by the immune cells.
BRAHMA: Planning Tool for Providing Storage Management as a Service (2007)

Storage management is becoming the largest component in the overall cost of storage ownership. Most organizations are trying to either consolidate their storage management operations or outsource them to a storage service provider (SSP) in order to contain the management costs. Currently, there do not exist any planning tools that help the clients and the SSPs in figuring out the best outsourcing option. In this paper we present a planning tool, Brahma, that specifically addresses the above mentioned problem, as Brahma is capable of providing solutions where the management tasks are split between the client and SSP at a finer granularity. Our tool is unique because: (a) in addition to hardware/software resources, it also takes human skill set as an input; (b) it takes planning time window as input because plans that are optimal for a given time period (e.g. a month) might not necessarily be the most optimum for a different time period (e.g. a year); (c) it can be used separately by both the client and the SSP to do their respective planning; (d) it allows the client and the SSP to propose alternative solutions if certain input service level agreements can be relaxed. We have implemented BRAHMA, and our experiment results show that there definitely are cost benefits that one can attain by having a tool with the above mentioned functional properties.
Potential measurement on cathodically protected structures using an integrated salt bridge and steel ring coupon (1996)

A unique probe configuration which incorporates a salt bridge and a fixed steel ring coupon to assist in making potential measurements on cathodically protected structures with consideration of voltage drop error is described. The paper describes the coupon, coupon size, probe design, field trials, experimental procedure, and results.