gebhart/patrepeval huggingface dataset:
Regulation of the NRG1/ErbB4 Pathway in the Intrinsic Cardiac Nervous System Is a Potential Treatment for Atrial Fibrillation (2018)

<b>Background:</b> The NRG1/ErbB4 signaling mechanism has been widely studied in the central nervous system for many years. However, the role of this pathway in modulating the intrinsic cardiac nervous system is largely unknown. <b>Objective:</b> The present study investigated whether the NRG1/ErbB4 signaling system affects the activity of major atrial ganglionated plexi (GP) in a paroxysmal atrial fibrillation (AF) model by 6-h rapid atrial pacing (RAP). <b>Methods:</b> Twenty-four dogs were randomly divided into (1) a control group (saline microinjections into GP), (2) RAP group (saline microinjections into GP plus 6 h-RAP), (3) NRG1 group (microinjections of neuregulin-1 into GP plus 6 h-RAP) and (4) NRG1 + ERA group (microinjections of neuregulin-1 and ErbB4 receptor antagonist-ERA into GP plus 6 h-RAP). The effective refractory period (ERP), window of vulnerability (WOV), anterior right GP (ARGP) function and neural activity were measured. ARGP tissues were excised for histological study and western blotting. <b>Results:</b> When compared to the control group, 6 h-RAP produced a significant (1) decrease in ERP, an increase in ΣWOV, (2) an increase in ARGP neural activity and neural function, and (3) an increase in c-fos and nerve growth factor protein expression in the ARGP. However, microinjection of NRG1 into the ARGP prior to RAP prevented ERP shortening and AGRP activity enhancement and inhibited the expression of c-Fos and NGF proteins. Furthermore, these changes were significantly attenuated by pretreatment with an ErbB4 receptor antagonist. <b>Conclusion:</b> The NRG1/ErbB4 signaling pathway may exist in the GP, and activation of this pathway suppressed RAP-induced GP activation, atrial electrical remodeling and AF.
Agile security testing of Web-based systems via HTTPUnit (2006)

The technological advancements of Web-based systems and the shift to iterative and evolutionary development processes have given rise to the idea of agile security testing, where the principles and practices of agile testing are applied to the domain of security testing. This paper explores common vulnerabilities for Web applications and proposes two synergistic approaches for mitigating them. The first approach is to employ a highly testable architecture in the development of Web-based systems, and the second is to support the security testing process using the open source unit testing framework HTTPUnit. The overall testing strategy mingles well with agile development efforts and gives the development team an opportunity to produce applications that have the "right" functionality and the "right" level of security.
Programa de actuaciones integrales para el sector El Guamacho. Ciudad histórica de La Guaira. Estado Vargas (2010)

La Guaira Historical City constitutes a Venezuelan vital patrimonial inventory piece; it combines many high historical and environmental elements. However, its preservation is now even more difficult due to abandonment, physical and economical degradation, little identification and attention from community, and minor interinstitutional support.Since 2000, Instituto de Estudios Regionales y Urbanos at Universidad Simon Bolivar (IERU-USB), with different organizations support, has carried out some activities in La Guaira Historical City, taking special attention to El Guamacho region. The main goal is to unite forces regarding technical teams, public and private institutions and the community, to recover historical cities in order to improve inhabitant’s surroundings and quality of life.
A Modular Machine Learning System for Flow-Level Traffic Classification in Large Networks (2012)

The ability to accurately and scalably classify network traffic is of critical importance to a wide range of management tasks of large networks, such as tier-1 ISP networks and global enterprise networks. Guided by the practical constraints and requirements of traffic classification in large networks, in this article, we explore the design of an accurate and scalable machine learning based flow-level traffic classification system, which is trained on a dataset of flow-level data that has been annotated with application protocol labels by a packet-level classifier. Our system employs a lightweight modular architecture , which combines a series of simple linear binary classifiers, each of which can be efficiently implemented and trained on vast amounts of flow data in parallel, and embraces three key innovative mechanisms, weighted threshold sampling, logistic calibration , and intelligent data partitioning , to achieve scalability while attaining high accuracy. Evaluations using real traffic data from multiple locations in a large ISP show that our system accurately reproduces the labels of the packet level classifier when runs on (unlabeled) flow records, while meeting the scalability and stability requirements of large ISP networks. Using training and test datasets that are two months apart and collected from two different locations, the flow error rates are only 3% for TCP flows and 0.4% for UDP flows. We further show that such error rates can be reduced by combining the information of spatial distributions of flows, or collective traffic statistics , during classification. We propose a novel two-step model, which seamlessly integrates these collective traffic statistics into the existing traffic classification system. Experimental results display performance improvement on all traffic classes and an overall error rate reduction by 15%. In addition to a high accuracy, at runtime, our implementation easily scales to classify traffic on 10Gbps links.
William I and the church courts (1967)

William I and the church courts Get access COLIN MORRIS COLIN MORRIS Pembroke CollegeOxford Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume LXXXII, Issue CCCXXIV, July 1967, Pages 449–463, https://doi.org/10.1093/ehr/LXXXII.CCCXXIV.449 Published: 01 July 1967
Speckle reduction in optical coherence tomography images of human skin by a spatial diversity method (2007)

A range of compounding techniques have been suggested for dealing with the signal degrading speckle noise in optical coherence tomography (OCT). Recent implementations of angular compounding have shown great promise, but some of the implementations require substantial modifications of the OCT system. Here, we consider a method that in principle can be fitted to most OCT systems without major modifications. Specifically, we address a spatial diversity technique for suppressing speckle noise in OCT images of human skin. The method is a variant of changing the position of the sample relative to the measuring probe. Instead of physically moving the sample, which is often not feasible for <i>in vivo </i>imaging, the position of the focal plane of the probe beam is shifted. If the numerical aperture is sufficiently high this spatial diversity scheme incorporates a variant of angular compounding. We have tested the scheme with a mobile fiber-based time-domain real-time OCT system. Essential enhancement was obtained in image contrast when performing <i>in vivo</i> imaging of normal skin and lesions. Resulting images show improved delineation of structure in correspondence with the observed improvements in contrast-to-noise ratios.
Signal processing approach to optimum preprocessing for on‐line recognition of handwritten japanese characters (1988)

Abstract With the recent tendency toward miniaturization and price‐down of tablet digitizers, they are expected to be used as the input device for handwritten characters and drawings. As the preprocessing for the point coordinate sequence read from a tablet, only empirical methods have been applied. This paper discusses the preprocessing from the viewpoint of signal processing, and a quantitative evaluation was made for the following two points: (1) directional stability of the preprocessed coordinate sequence; and (2) follow‐up (fidelity) of the preprocessed point sequence to the original point sequence. As a result, a performance superior to the traditional methods was obtained by the following four phases: 1 Adaptive sampling, where sharp corners are stressed, while the sampling points are set uniformly for slow pen movement; 2 interpolation, where the point interval is made uniform for fast pen movement; 3 smoothing by the moving‐average filter; and 4 thinning to eliminate redundant points. The point sequence after the proposed preprocessing has the following features: (1) The original point sequence is followed, being little affected by the pen speed; (2) the directional stability is achieved even for 32 directional quantizations in the straight‐line segmentation used by the authors; and (3) features such as sharp corners are preserved.
Expression of Rantes and Ccr5 in Rats with Experimental Autoimmune Anterior Uveitis (2005)

Objective: To determine the pattern of expression of RANTES and its receptor, CCR5, and to establish their roles in experimental autoimmune anterior uveitis, an animal model of human acute anterior uveitis. Methods: Uveitis was induced in the Lewis rats with the injection melanin-associated antigen into the left footpad. The rats were scored for the development of clinical disease. At defined tine points, RANTES and CCR5 mRNA expression were semiquantified by using RT-PCR. The concentration of RANTES protein in aqueous humor was quantified by ELSIA. Results: RANTES mRNA started increasing on day 11, concurrent with the infiltration of leukocytes in aqueous humor and onset of clinical disease. The concurrent with the infiltration of leukocytes in aqueous humor and onset of clinical disease. The concentration of RANTES protein also increased on day 11, Furthermore in accord with its ligand RANTES contributed to the recruitment of inflammatory cells into the eye and to the disease activity. RANTES could be potential targets for acute anterior uveitis therapy.
Enumeration and presumptive identification of some functional groups of bacteria in the rumen of dairy cows fed grass silage-based diets (1990)

Samples of rumen ingesta from two rumen-fistulated dairy cows fed grass silage-based diets were examined for numbers and types of bacteria that developed colonies on rumen fluid-agar media designated to support the growth of (a) a wide range of species, (b) cellulolytic bacteria, (c) lactate-fermenting bacteria, (d) non-fermentative bacteria. The most numerous species was Bacteroides ruminicola followed by Butyrivibrio fibrisolvens. The most abundant cellulolytic species were Eubacterium cellulosolvens and Ruminococcus flavefaciens. Megasphaera elsdenii and Selenomonas ruminantium were important lactate fermenters but an unidentified bacterium that grew poorly on maintenance medium was by far the most numerous among bacteria isolated from lactate-containing medium. One strain remained sufficiently viable to show that it fermented lactate to propionate and acetate.
Association of genetic variants of the α-kinase 1 gene with myocardial infarction in community-dwelling individuals (2013)

We previously demonstrated that rs2074380 (G→A, Gly870Ser) and rs2074381 (A→G, Asn916Asp) of the α-kinase 1 gene (<i>ALPK1</i>) were significantly associated with chronic kidney disease (CKD) in individuals with diabetes mellitus. As CKD is a significant risk factor for coronary heart disease, we hypothesized that rs2074380 and rs2074381 of <i>ALPK1</i> may contribute to the genetic susceptibility to myocardial infarction (MI) through affecting the susceptibility to CKD. The aim of the present study was to investigate a possible association of rs2074380 and rs2074381 with MI in community-dwelling individuals. The study subjects comprised 5,771 community-dwelling individuals (41 subjects with MI and 5,730 controls) who were recruited to a population-based cohort study in Inabe, Japan. The comparison of allele frequencies and genotype distributions using the Chi-square test revealed that rs2074380 and rs2074381 were significantly associated with MI (P<0.05). The multivariable logistic regression analysis with adjustment for covariates demonstrated that rs2074380 (P=0.0354, dominant model) and rs2074381 (P=0.0438, dominant model) were significantly associated with MI, with the minor <i>A</i> and <i>G</i> alleles, respectively, being protective against this condition. A haplotype analysis of these polymorphisms indicated that the frequency of the major haplotype, G (rs2074380)-A (rs2074381), was significantly higher (permutation P=0.012), whereas that of the minor haplotype A-G was significantly lower (P=0.020), in subjects with MI compared to that observed among controls. Therefore, <i>ALPK1</i> may be a susceptible locus for MI.
Fiber-Optic Chemical Sensors and Biosensors (2006)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFiber-Optic Chemical Sensors and BiosensorsOtto S. WolfbeisView Author Information Institute of Analytical Chemistry, University of Regensburg, D-93040 Regensburg, Germany Cite this: Anal. Chem. 2006, 78, 12, 3859–3874Publication Date (Web):April 15, 2006Publication History Published online15 April 2006Published inissue 1 June 2006https://pubs.acs.org/doi/10.1021/ac060490zhttps://doi.org/10.1021/ac060490zreview-articleACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views6204Altmetric-Citations256LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Fibers,Fluorescence,Probes,Quantum mechanics,Sensors Get e-Alerts
Modeling of the self-sustained, discharge-excited xenon-chloride laser (1991)

A kinetic model for the self-sustained, discharge-excited XeCl laser with Ne-Xe-HCI gas mixtures is described. The improvements include an improved treatment of the HCl vibrational kinetics and a detailed treatment of the XeCl excited-state manifold, and as a result the predictions of the model are in good agreement with several experiments covering a wide range of excitation conditions. Scaling investigations suggest that large improvements in the efficiency of self-sustained, discharge-excited XeCl lasers are not to be expected; however, the model predicts that efficient operation over pulse lengths of several microseconds may be possible if the present difficulties with discharge stability can be overcome.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An Autonomous Driving System for Unknown Environments Using a Unified Map (2015)

Recently, there have been significant advances in self-driving cars, which will play key roles in future intelligent transportation systems. In order for these cars to be successfully deployed on real roads, they must be able to autonomously drive along collision-free paths while obeying traffic laws. In contrast to many existing approaches that use prebuilt maps of roads and traffic signals, we propose algorithms and systems using Unified Map built with various onboard sensors to detect obstacles, other cars, traffic signs, and pedestrians. The proposed map contains not only the information on real obstacles nearby but also traffic signs and pedestrians as virtual obstacles. Using this map, the path planner can efficiently find paths free from collisions while obeying traffic laws. The proposed algorithms were implemented on a commercial vehicle and successfully validated in various environments, including the 2012 Hyundai Autonomous Ground Vehicle Competition.
Target‐Induced and Equipment‐Free DNA Amplification with a Simple Paper Device (2016)

We report on a paper device capable of carrying out target-induced rolling circle amplification (RCA) to produce massive DNA amplicons that can be easily visualized. Interestingly, we observed that RCA was more proficient on paper than in solution, which we attribute to a significantly higher localized concentration of immobilized DNA. Furthermore, we have successfully engineered a fully functional paper device for sensitive DNA or microRNA detection via printing of all RCA-enabling molecules within a polymeric sugar film formed from pullulan, which was integrated with the paper device. This encapsulation not only stabilizes the entrapped reagents at room temperature but also enables colorimetric bioassays with minimal steps.
A three-dimensional (3-D) substrate-guided-wave to free-space multistage optoelectronic interconnection using wavelength division multiplexing and space division demultiplexing (1996)

An integrated 3-D guided-free-space four-stage optoelectronic fan-out (6/spl times/6, 2/spl times/6, 6/spl times/6: and 2/spl times/6) interconnect using wavelength division multiplexing (WDM) is proposed and then demonstrated together with 40 (2/spl times/4/spl times/5) 3-D optoelectronic fan-outs using space division demultiplexing (SDDM). This channel separation is one order of magnitude smaller than that using wavelength-selective detecting techniques in WDM. A signal to noise ratio of 57 dB is experimentally determined, with two channel 40 (2/spl times/4/spl times/5) fan-outs having a channel separation of 600 /spl mu/m in SDDM. The interconnection scheme presented herein allows each pixel in a transmitting plane to communicate simultaneously and reconfigurably with many pixels in the subsequent planes in a truly 3-D feature. This system can utilize vertical cavity surface emitting laser diodes, photo detecting planes, and planar compact guided-free-space fan-out interconnects, allowing compact multistage integration. By using 2-D spatially separated or multiplexed hologram arrays on a thin light guiding plate, the interconnection capability is greatly enhanced as compared to other techniques. This novel optoelectronic interconnect technology may have widespread applications in microelectronic systems and fiber-optic communication networks.
Chemically derivatized n-type semiconducting germanium photoelectrodes. Persistent attachment and photoelectrochemical activity of ferrocene derivatives (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemically derivatized n-type semiconducting germanium photoelectrodes. Persistent attachment and photoelectrochemical activity of ferrocene derivativesJeffrey M. Bolts and Mark S. WrightonCite this: J. Am. Chem. Soc. 1978, 100, 17, 5257–5262Publication Date (Print):August 1, 1978Publication History Published online1 May 2002Published inissue 1 August 1978https://pubs.acs.org/doi/10.1021/ja00485a001https://doi.org/10.1021/ja00485a001research-articleACS PublicationsRequest reuse permissionsArticle Views196Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Use of the Low Air Loss Bed System in Treatment of Burns Patients (1979)

When a person is confined to bed, whatever the reason, small areas of soft tissues are compressed between the skeleton and the supporting surfaces. Transient circulatory disturbances resulting in epidermis to dermis damage or finally deep penetrating necrosis involving subcutaneous tissues, fascia muscle and bone may result. In the case of the severely burned patient who has already sustained gross trauma, any further destruction of tissues is to be avoided at all costs. The Low Air Loss Bed System offers many advantages in the care and management of the burns patient. There is a definite saving of nursing time by rendering unnecessary constant attention to the patient for preventative skin care, positioning, bed pan etc. The nurse is then able to devote her time positively to the more involved needs of the patient and family. It will also provide for periods of rest that are so often lacking, especially in the initial stages of treatment. The patient does not have to be kept on a rigid regime of Q2H turning. He is turned only for wound care, physio- and general body cleansing. His position may be contoured without having to touch him circumferentially. Any lifting and positioning necessary is easier for staff members due to the design of the unit, and more comfortable for the patient. Over a period of two years, eighteen patients with varying extent and degree of burn injuries were treated on the bed. This paper will describe the mechanical operation of the bed and experiences with nursing management and monitoring of the system.
Breakdown of Weak-Field Magnetotransport at a Metallic Quantum Critical Point (2005)

We show how the collapse of an energy scale in a quantum critical metal can lead to physics beyond the weak-field limit usually used to compute transport quantities. For a density-wave transition we show that the presence of a finite magnetic field at the critical point leads to discontinuities in the transport coefficients as temperature tends to zero. The origin of these discontinuities lies in the breakdown of the weak-field Jones-Zener expansion which has previously been used to argue that magnetotransport coefficients are continuous at simple quantum critical points. The presence of potential scattering and magnetic breakdown rounds the discontinuities over a window determined by tauDelta < 1 where Delta is the order parameter and tau is the quasiparticle elastic lifetime.
Functional Health Pattern Assessment: A Seasonal Migrant Farmworker Community (1990)

A broad-based needs assessment of a migrant farmworker community was conducted using the community functional health pattern tool (Gikow & Kucharski, 1987) and Porter's (1987) factor-isolating theory of population group diagnosis. Data analysis revealed numerous health needs in all 10 functional health patterns and an urgent need for accessible primary prevention programs. A mobile outreach program to the migrant camps was seen as the most effective way to provide education, screening, and health care.