gebhart/patrepeval huggingface dataset:
Posttranscriptional Regulation of Chicken <i>ccn2</i> Gene Expression by Nucleophosmin/B23 during Chondrocyte Differentiation (2008)

CCN2/CTGF is a multifunctional factor that plays a crucial role in the growth and differentiation of chondrocytes. The chicken ccn2 gene is regulated not only at the transcriptional level but also by the interaction between a posttranscriptional element in the 3' untranslated region (3'-UTR) and a cofactor. In the present study, we identified a nucleophosmin (NPM) (also called B23) as this cofactor. Binding of NPM to the element was confirmed, and subsequent analysis revealed a significant correlation between the decrease in cytosolic NPM and the increased stability of the ccn2 mRNA during chondrocyte differentiation in vivo. Furthermore, recombinant chicken NPM enhanced the degradation of chimeric RNAs containing the posttranscriptional cis elements in a chicken embryonic fibroblast extract in vitro. It is noteworthy that the RNA destabilization effect by NPM was far more prominent in the cytosolic extract of chondrocytes than in that of fibroblasts, representing a chondrocyte-specific action of NPM. Stimulation by growth factors to promote differentiation changed the subcellular distribution of NPM in chondrocytes, which followed the expected patterns from the resultant change in the ccn2 mRNA stability. Therefore, the present study reveals a novel aspect of NPM as a key player in the posttranscriptional regulation of ccn2 mRNA during the differentiation of chondrocytes.
Pre-Trained Image Processing Transformer (2020)

As the computing power of modern hardware is increasing strongly, pre-trained deep learning models (e.g., BERT, GPT-3) learned on large-scale datasets have shown their effectiveness over conventional methods. The big progress is mainly contributed to the representation ability of transformer and its variant architectures. In this paper, we study the low-level computer vision task (e.g., denoising, super-resolution and deraining) and develop a new pre-trained model, namely, image processing transformer (IPT). To maximally excavate the capability of transformer, we present to utilize the well-known ImageNet benchmark for generating a large amount of corrupted image pairs. The IPT model is trained on these images with multi-heads and multi-tails. In addition, the contrastive learning is introduced for well adapting to different image processing tasks. The pre-trained model can therefore efficiently employed on desired task after fine-tuning. With only one pre-trained model, IPT outperforms the current state-of-the-art methods on various low-level benchmarks. Code is available at https://github.com/huawei-noah/Pretrained-IPT and https://gitee.com/mindspore/mindspore/tree/master/model_zoo/research/cv/IPT
Wolman's disease: a microscopic and biochemical study showing accumulation of ceroid and esterified cholesterol. (1970)

A case of Wolman's disease is described in a female infant who died at 7 weeks of age. This rare familial disorder is characterized by bilateral adrenal calcification and the accumulation of esterified cholesterol in many tissues. For the first time large quantities of ceroid have been demonstrated in the liver, spleen, adrenals, lymph nodes and particularly within the lamina propria of the small intestine. It is postulated that there exists in these patients a decreased activity of cholesterol esterases. The accumulated cholesterol esters may then be oxidized to form ceroid. Since ceroid is quite impermeable, intestinal absorption is progressively impaired, leading ultimately to death.
Hand-off analysis for an integrated satellite and terrestrial mobile system over a fading channel (2003)

An integrated satellite and terrestrial mobile system enables the satellite mobile terminal (MT) to access the land mobile satellite system (LMSS) inside the coverage of a terrestrial network. When the MT operates inside an urban area, base stations of the terrestrial network will act as relay stations for the LMSS. The hand-off analysis for the two systems is an important issue. A mathematical model is developed to simulate the received signals at the MT over a Rayleigh fading channel. By using this model, the effects of level-crossing rate (LCR) on hand-off criteria for the integrated system are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Design Feasibility of a Free Piston Internal Combustion Engine/Hydraulic Pump (1988)

<div class="htmlview paragraph">A direct acting free piston internal combustion engine/hydrostatic pump is analyzed. This device would take the place of a conventional engine-driven hydrostatic pump, and would be expected to offer significant advantages in cost, weight, and efficiency. The free piston configuration eliminates the need for a crankshaft-connecting rod system, and the comparable mechanism of the pump that converts rotary to reciprocating motion. Analysis of the design was done by computer simulation using a thermodynamic model of the combustion cylinder in combination with the system dynamics. A parametric study was performed to determine operating characteristics with a wide variety of mechanical parameters, and as a guide to developing a preliminary design. The results show that good performance is possible with reasonable mechanical dimensions and other parameters. Several different design configurations are presented.</div>
Measuring shape: ellipticity, rectangularity, and triangularity (2002)

Object classification often operates by making decisions based on the values of several shape properties measured from the image. The paper describes and tests several algorithms for calculating ellipticity, rectangularity, and triangularity shape descriptors.
A method for approximate fully bayesian analysis of parameters (1997)

Stochastic modeling of the geology in petroleum reservoirs has become an important tool in order to investigate flow properties in the reservoir. The stochastic models used contain parameters which must be estimated based on observations and geological knowledge. The amount of data available is however quite limited due to high drilling costs etc., and the lack of data prevents the use of many of the standard data driven approaches to the parameter estimation problem. Modern simulation based methods using Markov chain Monte Carlo simulation, can however be used to do fully Bayesian analysis with respect to parameters in the reservoir model, with the drawback of relatively high computational costs. In this paper, we propose a simple, relatively fast approximate method for fully Bayesian analysis of the parameters. We illustrate the method on both simulated and real data using a two-dimensional marked point model for reservoir characterization.
Resveratrol Modulates Phagocytosis of Bacteria through an NF-κB-Dependent Gene Program (2007)

Many studies have shown that the pharmacological effects of resveratrol, a phytoalexin polyphenolic compound, include protective effects against cancer and inflammation as well as enhancement of stress resistance. In this study, we examined whether resveratrol affected the phagocytosis of bacteria by macrophages and the activation of the transcription factor NF-kappaB after stimulation with or without the ligand FSL-1 for Toll-like receptor 2 (TLR2). Phagocytosis of Escherichia coli and of Staphylococcus aureus by THP-1 cells and RAW264.7 cells was inhibited by resveratrol in a dose-dependent manner regardless of stimulation with FSL-1. The NF-kappaB activity in HEK293 cells stably expressing TLR2 was also inhibited by resveratrol after stimulation with FSL-1. Resveratrol also inhibited both the translocation of p65 of NF-kappaB into nuclei in the transfectant and tumor necrosis factor alpha production by THP-1 cells or RAW264.7 cells. It has recently been reported that TLR-mediated signaling pathways lead to the upregulation of mRNAs of phagocytic receptors, including scavenger receptors and C-type lectin receptors. This study also demonstrated that FSL-1 induced the upregulation of mRNAs of phagocytic receptors such as macrophage scavenger receptor-1, CD36, DC-SIGN, and Dectin-1 and that the FSL-1-induced upregulation of their mRNAs was inhibited by resveratrol. In addition, it was found that the expression of DC-SIGN in HEK293 cells stably expressing DC-SIGN was reduced by resveratrol and that the phagocytic activity was significantly inhibited by resveratrol. Thus, this study suggests that resveratrol inhibited bacterial phagocytosis by macrophages by downregulating the expression of phagocytic receptors and NF-kappaB activity.
Demonstration of glucose 6-phosphatase activity in the oval cells of rat liver and the significance of the oval cells in azo dye carcinogenesis. (1974)

Glucose 6-phosphatase activity was studied histochemically in the oval cells of rat livers during the early stage of hepatocarcinogenesis induced by 3′-methyl-4-dimethylaminoazobenzene. Short-period perfusion fixation of the liver preserved both the ultrastructure of the liver cells and glucose 6-phosphatase activity excellently throughout the whole hepatic tissue. Under light microscopic examination of the liver of rats fed the azo dye diet, glucose 6-phosphatase activity was found in the oval cell proliferating area in varying degrees. The electron microscopic study demonstrated that the oval cells formed ductular structures with elaborated basal laminae, and were occasionally found within the space of Disse between the hepatocytes. Ultrastructurally, some oval cells were identical to bile ductular cells, while others showed various transitional cytostructural characteristics between ductular cells and hepatocytes. An electron microscopic histochemical study revealed various intensities of glucose 6-phosphatase activity in the endoplasmic reticulum and nuclear envelope of the oval cells. The intensity of glucose 6-phosphatase activity in the oval cells was nearly proportional to their grade of morphological resemblance to the hepatocytes. The findings presented in this report indicate that the oval cells transform into hepatocytes through various transitional phases during azo dye carcinogenesis.
Viral Macro Domains Reverse Protein ADP-Ribosylation (2016)

Protein ADP-ribosylation is a covalent posttranslational modification regulating cellular protein activities in a dynamic fashion to modulate and coordinate a variety of cellular processes. Three viral families, Coronaviridae, Togaviridae, and Hepeviridae, possess macro domains embedded in their polyproteins. Here, we show that viral macro domains reverse cellular ADP-ribosylation, potentially cutting the signal of a viral infection in the cell. Various poly(ADP-ribose) polymerases which are notorious guardians of cellular integrity are demodified by macro domains from members of these virus families. In the case of hepatitis E virus, the adjacent viral helicase domain dramatically increases the binding of the macro domain to PAR and simulates the demodification activity.
Copolymers Comprising Monomers with Various Dipoles and Quadrupole as Active Material in Organic Field Effect Transistors (2016)

Copolymers of 4,4-difluoro-4-borata-3a-azonia-4a-aza-s-indacene (BODIPY) and diketopyrrolopyrrole (DPP) were synthesized. The BODIPY has a permanent dipole and the DPP has a quadrupole. The dipole and the quadrupole in the monomers are expected to bring the polymers closer and to improve the charge-transport properties. By judicious choice of these monomers, the electron wave function is evenly distributed through the molecules. However, we notice that the torsional angle at the connecting point of BODIPY and DPP is a function of the methyl moieties at the β, β′ position of the BODIPY. We found that the polymer comprising DPP and BODIPY without methyl moiety at β, β′ position showed a torsional angle of 27°, the lowest among the three polymers studied in this work. The absorption spectrum of the polymer showed transitions because of vibronic coupling indicating linearity along the polymer backbone. The band gap of the polymer was found to be 1.2 eV. The thermally stable polymer showed an ambipolar charge transport of 0.01 cm2/(V s).
[Low concentration level of total serum cholesterol as a risk factor for suicidal and aggressive behavior]. (1996)

The data have been presented for possible association between low total serum cholesterol concentration and the increased risk of suicidal and aggressive behavior. The analysis of results from some long-term epidemiological studies shows an excess of suicides and violent death cases among persons with low baseline total serum cholesterol level and in those in whom this level was lowered by means of pharmacotherapy or dieting. In patients hospitalized on psychiatric wards, having low total serum cholesterol concentration, a higher intensity of suicidal thoughts and tendencies was found. Such relationship was most evident in patients with depression. In some populations, an association between low total cholesterol level and the tendency to aggressive behavior was also found. Higher intensity of aggression was also observed in animals receiving low-cholesterol diet. A hypothesis was discussed, postulating the connection between low cholesterol level and lower activity of central serotonergic structures responsible for the inhibition of impulsive behavior.
Weakening internal diffusion effect in selective hydrodesulfurization of FCC gasoline by novel designed eggshell CoMoS/Al_2O_3 catalysts (2012)

为有锋利的边界的 presulfided 蛋壳 CoMoS/-Al2O3 催化剂的准备的一个简单方法被开发，通过哪个公司和瞬间的蛋壳厚度能被控制受精时间容易调整。在一致催化剂上根据吸附的公司，活跃部件结构，性质或活跃地点的数量的版本， XRD， HRTEM 和英尺红外在蛋壳催化剂上描绘的结果类似于这些。在 FCC 汽油的选择 hydrodesulfurization (HDS ) 的催化表演的评估结果特别在一致催化剂在 S 混合物的 HDS 上显示出重要内部散开抑制效果的存在。与一致催化剂相比，蛋壳催化剂能显著地由于反应物，因此出现的更高的 HDS 活动和选择的一条弄短的散开路径减少如此的内部散开抑制效果。
Prediction of subclinical renal allograft rejection by vascular endothelial growth factor in serum and urine. (2008)

It is first reported that the monitoring of VEGF in serum and urine might be a new noninvasive approach to supplement a protocol biopsy for detection of subclinical rejection.
The Case for United States Reparations to African Americans (2000)

The political and juridical viability of reparations for descendants of enslaved black people is emerging as a highly contested concept in U.S. debates about justice and law. For decades, reparations have been an essential part of the international discourses of war and human rights.
Hollow nanoparticles excel in lubrication (1997)

RETURN TO ISSUEPREVNewsNEXTHollow nanoparticles excel in lubricationRON DAGANICite this: Chem. Eng. News 1997, 75, 25, 9Publication Date (Print):June 23, 1997Publication History Published online12 November 2010Published inissue 23 June 1997https://pubs.acs.org/doi/10.1021/cen-v075n025.p009ahttps://doi.org/10.1021/cen-v075n025.p009anewsACS PublicationsCopyright © 1997 AMERICAN CHEMICAL SOCIETYArticle Views9Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Hollow structures,Tungsten disulfide Get e-Alerts
Exploring regulatory mechanisms of CD8 <sup>+</sup> T cell contraction (2008)

A small fraction of the CD8 T cell effector population that responds to an infection progresses through the contraction phase to the memory stage. The factors regulating the extent of contraction are poorly understood. Competition for limited resources has been widely postulated to be the cause of cell death during the contraction phase, but our data show that competition does not affect contraction kinetics. We go on to demonstrate that all effector cells present at the peak of the response have the potential to become bona fide memory cells, thus excluding selection on the basis of functionality. We propose that the fate of a CD8 effector cell is predetermined before the onset of contraction and discuss possible mechanisms of regulation.
RESPONSE: Re: Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4 (1999)

We determined that a single base change in the 5' flanking region of the CYP3A4 gene was associated with higher clinical stage and grade in men with prostate tumors. Our results suggest that mutations in the CYP3A4 gene may influence prostate carcinogenesis.
RemineraIization of Natural and Artificial Lesions in Human Dental Enamel in vitro (1981)

Exposure of both small carious lesions and artificial caries-like lesions to a synthetic calcifying fluid in vitro produced a significant degree of ‘healing’ or remineralization of the lesion. Changing the calcium concentration of the calcifying fluid had a marked effect on the degree of remineralization produced. When a low calcium concentration of 1 mM was employed, remineralization occurred throughout the entire depth of a lesion. Under these conditions, there was a mean reduction of 69% in area of the body of the lesion and a mean increase of 40% in orientated mineral. The dark zone at the advancing front of the lesion showed a dramatic increase in area of 526% and was much closer to the enamel surface relative to the control. When higher calcium ion concentrations of 3 mM were used, remineralization occurred but was limited to the surface of the lesion. Under these conditions, the mean reduction in area of the body of the lesion was 20%, brought about by a mean increase in orientated mineral of 17%. Although changes were found in relation to the dark zone, these were much smaller than those found for the 1-mM fluid, the increase in area being 38%. With respect to exposure times, results obtained using ten consecutive 24-hour exposures to the synthetic calcifying fluid were similar to those obtained after ten consecutive 1-hour exposures. Remineralization, therefore, occurred within each 1-hour exposure increment. Scanning electron microscopy showed that crystal diameters for sound enamel were in the range 35–40 nm. In the body of the lesion crystal diameters were reduced and found to be in the range 10–30 nm. In lesions remineralized with the high calcium-calcifying fluid containing 3 mM calcium, crystal diameters were larger than those found in either control lesions or in sound enamel, being in the range 50–75 nm. When the low calcium-calcifying fluid was used, remineralized lesions showed crystal diameters in the range 50–150 nm with a small number of crystals having diameters of 200 nm. Calculation of the supersaturation of the calcifying fluids revealed that the low calcium-calcifying fluid having 1 mM calcium favors crystal growth as opposed to nucleation.
Expert system design for credit risk evaluation using neuro‐fuzzy logic (2010)

Abstract Over the past few years, the credit risk evaluation of micro‐, small‐ and medium‐scale enterprises by banks and financial institutions has been an active area of research under the joint pressure of regulators and shareholders. The credit rating assessment forms an important part of credit risk assessment, involving risk parameters such as financial, business, industry and management areas. The mathematical models of evaluation are at the core of modern credit risk management systems. This paper focuses on the use of fuzzy logic and neural network techniques to design a methodology for evaluating the credit worthiness of the entrepreneur. The neuro‐fuzzy logic approach takes into account the minute details of credit rating expert's thought process to arrive at the final decision. A flexible credit rating framework (CRF) has been designed to organize all the facts of the client in a hierarchical fashion. The neural networks provide self‐learning capability to the CRF. The CRF can be customized to suit different business and industrial interests.
Face Interface : a methodology for experimental learning of input modalities (2007)

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2007.
Changes in Endometrial<i>PTEN</i>Expression throughout the Human Menstrual Cycle<sup>1</sup> (2000)

Frequent mutation of the PTEN tumor suppressor gene in endometrial adenocarcinoma has led to the prediction that its product, a phosphatase that regulates the cell cycle, apoptosis, and possibly cell adhesion, is functionally active within normal endometrial tissues. We examined PTEN expression in normal human endometrium during response to changing physiological levels of steroid hormones. PTEN ribonucleic acid levels, assessed by RT-PCR, increase severalfold in secretory compared to proliferative endometrium. This suggested that progesterone, a known antineoplastic factor for endometrial adenocarcinoma, increases PTEN levels. Immunohistochemistry with an anti-PTEN monoclonal antibody displayed a complex pattern of coordinate stromal and epithelial expression. Early in the menstrual cycle under the dominant influence of estrogens, the proliferative endometrium shows ubiquitous cytoplasmic and nuclear PTEN expression. After 3-4 days of progesterone exposure, glandular epithelium of early secretory endometrium maintains cytoplasmic PTEN protein in an apical distribution offset by expanding PTEN-free basal secretory vacuoles. By the midsecretory phase, epithelial PTEN is exhausted, but increases dramatically in the cytoplasm of stromal cells undergoing decidual change. We conclude that stromal and epithelial compartments contribute to the hormone-driven changes in endometrial PTEN expression and infer that abnormal hormonal conditions may, in turn, disrupt normal patterns of PTEN expression in this tissue.
Review of the anticancer activities of bee products (2014)

Bee products have long been used in traditional medicine. The raw materials, crude extracts and purified active compounds from them have been found to exhibit interesting bioactivities, such as antimicrobial, anti-inflammatory and antioxidant activities. In addition, they have been widely used in the treatment of many immune-related diseases, as well as in recent times in the treatment of tumors. Bee product peptides induce apoptotic cell death in vitro in several transformed (cancer) human cell lines, including those derived from renal, lung, liver, prostate, bladder and lymphoid cancers. These bioactive natural products may, therefore, prove to be useful as part of a novel targeted therapy for some types of cancer, such as prostate and breast cancer. This review summarizes the current knowledge regarding the in vivo and in vitro potential of selective bee products against tumor cells.