gebhart/patrepeval huggingface dataset:
Screening and Determination of Kinetic Parameters of Aromatase Inhibitors Using Human Genital Skin Fibroblasts (1993)

The screening of aromatase inhibitors usiing human genital skin fibroblasts (GSF) in culture is described. Using this system the selectivity in detecting inhibition compares well with that for human full-term placenta as a source of enzyme. IC50 and Ki values may be determined using GSF and the ranking of a group of known inhibitors tested compares with that using placental enzyme. The advantages of this method are that the tissue is readily available and the long term freezing of viable cells allows a ready supply of material for repeated experiments.
Synthesis and antimicrobial activity of some thiazolinyl tetrahydrobenzo[b]thiophenes and thiazolinyl tetrahydrobenzothieno[2,3-d]pyrimidin-4-ones. (1992)

Two series of novel 3-carbethoxy-2-(3',4'-disubstituted-2',3'- dihydrothiazol-2'-ylidenamino)-4,5,6,7-tetrahydrobenzo[b] thiophenes (3a-o) and 2-methyl-3-(3',4'-disubstituted-2',3'-dihydrothiazol-2'-ylidena mino-5,6,7,8- tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H) ones (8a-o) have been synthesized and tested for antimicrobial activity. All members of the series have been found to exhibit in vitro antibacterial and/or antifungal activities. Activity was optimized by cyclization to the thienopyrimidin-4-ones. In particular, compounds 8e and 8fd were the most active against the 3 tested microorganisms. Their antifungal activity was higher than that exhibited by nystatin while their MIC was found to be nearly equal to that of nystatin.
The atomic simulation environment—a Python library for working with atoms (2017)

The atomic simulation environment (ASE) is a software package written in the Python programming language with the aim of setting up, steering, and analyzing atomistic simulations. In ASE, tasks are fully scripted in Python. The powerful syntax of Python combined with the NumPy array library make it possible to perform very complex simulation tasks. For example, a sequence of calculations may be performed with the use of a simple 'for-loop' construction. Calculations of energy, forces, stresses and other quantities are performed through interfaces to many external electronic structure codes or force fields using a uniform interface. On top of this calculator interface, ASE provides modules for performing many standard simulation tasks such as structure optimization, molecular dynamics, handling of constraints and performing nudged elastic band calculations.
www.lugardocorpo.com.Br (2003)

Pensar o corpo é pensar um paradoxo: ele é um lugar, um processo de disputa entre objetividade e subjetividade, sobre o humano e o não humano, sobre arte e ciência. Falar do corpo é falar desse grande paradoxo, em constante devir porque o corpo é um SENDO, que carrega nossa memória, nossos tempos (ou nosso tempo) e nossas sensibilidades. Definido como esse "carregador" de um processo permanente, cheio de memórias e sensibilidades, traz em sua existência a materialização de humanidades. Graças às tecnologias de comunicação, o corpo hoje pode estar em muitos lugares. O interior do corpo pode ser minuciosamente transparente e translúcido e, mais importante, visível em sua interioridade orgânica. Novas tecnologias médicas e científicas e objetos cada vez menores e mais eficazes são capazes de explorar esse espaço fluído, antes cheio de segredos. Ganho de complexidade: o corpo é pensado e atravessado por diferentes tecnologias. Ele tornou-se virtual.
Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells (2005)

We have previously reported that 1-benzyl-2-acetamido-2-deoxy-alpha-D-galactopyranoside (GalNAc alpha-O-bn), an inhibitor of glycosylation, perturbed apical biosynthetic trafficking in polarized HT-29 cells suggesting an involvement of a lectin-based mechanism. Here, we have identified galectin-4 as one of the major components of detergent-resistant membranes (DRMs) isolated from HT-29 5M12 cells. Galectin-4 was also found in post-Golgi carrier vesicles. The functional role of galectin-4 in polarized trafficking in HT-29 5M12 cells was studied by using a retrovirus-mediated RNA interference. In galectin-4-depleted HT-29 5M12 cells apical membrane markers accumulated intracellularly. In contrast, basolateral membrane markers were not affected. Moreover, galectin-4 depletion altered the DRM association characteristics of apical proteins. Sulfatides with long chain-hydroxylated fatty acids, which were also enriched in DRMs, were identified as high-affinity ligands for galectin-4. Together, our data propose that interaction between galectin-4 and sulfatides plays a functional role in the clustering of lipid rafts for apical delivery.
"NET-AN" a full three-dimensional parasitic interconnect distributed RLC extractor for large full chip applications (2002)

A full 3D RLC extraction capability is presented which is suitable for very large nets on very large chips. The need, solution methodology, and usage in a real design environment are shown. The extracted parasitics and their effects on the delay/skew numbers are presented for real clock distribution circuits from real production designs, not test chips or special layouts.
Dopants, defects and diffusion (1995)

Silicon is the driving force behind the information superhighway, multimedia and all the other much-hyped trends that have suddenly been noticed by the media in the past two years. This information revolution has been made possible by the phenomenal advances in the manufacture of silicon-based integrated circuits. The cost of storing or processing a single bit of information has fallen by factors of a million over the last couple of decades. Indeed, consumers can now put the equivalent of a 1983 supercomputer on their kitchen table.
Area efficient floating-point adder and multiplier with IEEE-754 compatible semantics (2014)

In this paper we describe an open source floating-point adder and multiplier implemented using a 36-bit custom number format based on radix-16 and optimized for the 7-series FPGAs from Xilinx. Although this number format is not identical to the single-precision IEEE-754 format, the floatingpoint operators are designed in such a way that the numerical results for a given operation will be identical to the result from an IEEE-754 compliant operator with support for round-to-nearest even, NaNs and Infs, and subnormal numbers. The drawback of this number format is that the rounding step is more involved than in a regular, radix-2 based operator. On the other hand, the use of a high radix means that the area cost associated with normalization and denormalization can be reduced, leading to a net area advantage for the custom number format, under the assumption that support for subnormal numbers is required. The area of the floating-point adder in a Kintex-7 FPGA is 261 slice LUTs and the area of the floating-point multiplier is 235 slice LUTs and 2 DSP48E blocks. The adder can operate at 319 MHz and the multiplier can operate at a frequency of 305 MHz.
A service oriented framework for cloud computing (2012)

At the moment, cloud computing has an interesting progression in academic and industrial areas. Many well-known companies like Microsoft, Amazon, Google and IBM has built their own clouds in addition to many other open source cloud computing platforms and frameworks. There are many characteristics which a cloud should have. Many of the existing platforms and frameworks lack of some of these characteristics, for example most of them cannot really be integrated, all of them just give the user some tools and platforms (such as service bus and development kits), but there is no provided intelligence and automation. This paper proposes a framework that supports all of the mentioned characteristics and some others like low coupling and high integration. The proposed framework not only supports traditional cloud facilities, but using a service, adds intelligence to cloud to provide an automatic environment. To achieve the above mentioned goals, we have founded our framework on SOA (service oriented architecture) that manages data flow with an event driven approach.
Uterine artery embolization: Where does it stand in the management of uterine leiomyomas? Part 2 (2004)

Uterine artery embolization is a minimally invasive technique that is gaining popularity as a safe and effective alternative to myomectomy and hysterectomy. This first part of a two-part series on the management of uterine fibroids discusses uterine artery embolization: when it is applicable, how to perform it, and what to expect from the procedure.
Interactive Editing Systems: Part II (1982)

This article, Part II of a two-part series, surveys the state of the art of computer-based interactwe editing systems. This paper is a survey intended for a varied audience, including the more experienced user and the editor-designer as well as the curious novice. It presents numerous examples of systems in both the academic and commercial arenas, covering line echtors, screen editors, interactive editor/formatters, structure editors, syntax-directed editors, and commercial word-processing editors. We discuss pertinent issues in the field, and conclude with some observations about the future of interactive editing. The references for both parts are provided at the end of Part II.
Environmental Tobacco Smoke, Genetic Susceptibility, and Risk of Lung Cancer in Never-Smoking Women (1999)

A common genetic polymorphism divides the population of never smokers into two groups of approximately equal size, one (homozygous carriers of the GSTM1 null allele) that has a statistically significant greater risk of lung cancer from ETS than the other (heterozygous or homozygous carriers of the wild-type GSTM1 allele).
Lanzamiento de la nueva Serie 7 de excavadoras de ruedas Komatsu (2003)

El pasado 17 de enero tuvo lugar la presentacion a la prensa tecnica de las nuevas excavadoras de ruedas Komatsu de la Serie Dash 7, en concreto los modelos PW200-7 y PW220-7 de la clase de 20 y 22 t de peso, disenadas y fabricadas para el mercado europeo. La presentacion tuvo lugar en la fabrica que Komatsu posee en las cercanias de Newcastle (Inglaterra). En este reportaje se exponen las especificaciones y caracteristicas principales de los dos nuevos modelos presentados, asi como su proceso productivo
Career experiences of women in business (2018)

Purpose: This research study explores within the context of the current German legally binding gender quota debate what catalysts and barriers to success women on their career path to top positions in the German Automotive Industry experience.Design/Methodology/Approach: The design draws on data analysis and findings from 16 interviews completed by female and male managers in top leading positions from the German automotive industry.The applied methods have been considered by looking at the world as a social constructionist.The interview consisted of two parts: a) a biographical narrative and b) their vantage point of perceived supporting people or factors, barriers, embedded images experienced and a legally binding quota to create a power shift.The data from the transcripts was analysed via thematic analysis resulting in a cross-tabulation and subsequent stories and drawings. Findings:The study enables an understanding for the managers in leading positions involved in this research study and what the interviewees perceived as supporters and barriers on their career path to top leadership positions. Research limitations:The research study has been situated within a specific business context and has only been able to draw on a limited number of participants.Practical implications: Being aware of the implications certain power dynamics, embedded images and perceptions towards mentor relationships might have for women on their career path to top positions in the German Automotive Industry, means being able to partly influence and change circumstances in its favour.Originality/value: It presents an extreme case for the exploration of power dynamics, embedded images and the gender-related perception of mentoring as a key influence on gender diversity for women as female leaders in management positions.
Live and let live: insights into powdery mildew disease and resistance (2002)

SUMMARY Powdery mildew is a common fungal disease of many monocotyledonous and dicotyledonous plant species. In a moderately temperate and humid climate, these ascomycete fungi cause severe yield losses in a wide range of crops. In recent years, several plant genes encoding proteins that control disease resistance against powdery mildew were isolated from the model organism Arabidopsis and the crop barley. Here we review the presumptive biochemical functions of the respective proteins and discuss potential mechanisms which mediate pathogen recognition, resistance signalling, and the termination of host colonization. Perhaps not surprisingly, these advances also promise to shed light on the molecular basis of pathogenesis and biotrophic lifestyle.
Thrombin Generation in Platelet-Poor Plasma Is Normal in Patients with Hereditary Mucocutaneous Haemorrhages (2003)

Mild hereditary bleeding disorders presenting with mucocutaneous haemorrhages are usually difficult to diagnose. We measured thrombin generation in platelet-poor plasma (TG-PPP) in 206 patients with a clinically unequivocal bleeding tendency: 45 with von Willebrand disease (vWD), 49 with platelet aggregation/secretion defects (PASD), 10 with a combination of both and 102 who did not fit the diagnostic criteria for any known haemostatic disorder. TG-PPP was not significantly different from controls in all patient groups, indicating that an abnormality in the plasmatic clotting system is unlikely to contribute to the bleeding in patients with type 1 vWD and PASD. In patients with undiagnosed mild hereditary bleeding disorders, there must be other mechanisms which explain the abnormal haemorrhagic tendency, most likely as yet unrecognized defects in platelet-vessel wall interaction. As a next step we plan to investigate thrombin generation in PRP.
Identification of Selected Gamma-Ray Induced Deficiencies in Zebrafish Using Multiplex Polymerase Chain Reaction (1996)

The ease with which mutations can be generated in zebrafish makes this vertebrate an important resource for developmental genetics and genome studies. We have developed a PCR-based screening method that allows the efficient identification of gamma-ray induced deficiencies targeted to selected sequences. We describe three mutants characteristic of our findings and show that these mutations include deletions and translocations that can affect as much as 1% of the genome. These deficiencies provide a basis for analyzing the functions of cloned zebrafish genes using noncomplementation screens for point mutations induced by high-efficiency chemical mutagenesis.
Advanced methods for analysis of lot-to-lot yield variation (2002)

An automated system for analyzing lot-to-lot yield variation has been developed and implemented at AMD's Submicron Development Center (SDC). The automated nature of data preparation and analysis provided an efficient and accurate means to identify process excursions and sub-par processing tools. The signal detection capability of this system has been greatly enhanced by advanced features such as interaction and spatial analyses. Furthermore, its link to the inline defect monitor and the wafer-position-tracking system (WPT) added to the robustness of the system. Quick and accurate identification of process variations has led to tightening of the yield distribution and thus increased die output.
Transmission line analysis of nonlinear slot coupled microstrip antenna (1992)

The transmission line method is used for the analysis of microstrip antennas fed by several nonlinear slots with ‘H’ shapes [see ref. 1] or new geometries ‘└┘’, ‘└┐’ and ‘└─’ types. This analysis allows the input impedance of nonlinear slot coupled microstrip antennas to be calculated for the four different structures. The theoretical results are in good agreement with experiments.
A System for Automatic Iris Capturing (2005)

Biometrics is increasingly important in security applications. Iris recognition provides the greatest accuracy among known biometrics. The accuracy of iris recognition is, for example, much greater than face recognition and fingerprint recognition. However, it is not trivial to capture iris images in practice, and usually the users need to adjust their eye positions for iris image acquisition (e.g., the classical Daugman´s and Wildes systems). This paper describes a new system to capture iris images automatically without user interaction. It works at a distance of over l meter to the users. Experimental results demonstrate the performance of the system.
Night Vision Testing in Unoperated Eyes (1996)

Our Night Vision Recording Chart offers a simple, reproducible method to characterize image degradation under scotopic conditions.
Primary Human Immunodeficiency Virus Type 1 Infection: Review of Pathogenesis and Early Treatment Intervention in Humans and Animal Retrovirus Infections (1993)

Primary human immunodeficiency virus type 1 (HIV-1) infection can present clinically as the abrupt onset of a febrile illness resembling acute mononucleosis. The symptoms coincide with high titers of culturable plasma viremia, cell-associated virus, and antigenemia, which rapidly decrease coincident with the emergence of detectable HIV-specific antibody and HIV-specific cytotoxic T lymphocytes. This article reviews the human and animal model data on the virologic and immunologic events that occur during primary HIV-1 and animal retrovirus infections, evaluates the prophylactic treatment experience of retrovirus infections in the animal model, and provides a plausible rationale for treatment intervention of primary HIV-1 infection in humans. Recent work delineating the pathogenesis of primary HIV-1 infection provides insight into the major mechanisms of viral dissemination and host immune response. The results from retrovirus-infected animal models treated with antiviral agents suggests that therapy at the time of viral dissemination may be an effective strategy that may modify disease progression. Clinical trials to evaluate this approach are in progress.
Boolean Operations on 3D Selective Nef Complexes: Optimized Implementation and Experiments (2005)

Nef polyhedra in $d$-dimensional space are the closure of\nhalf-spaces under boolean set operation. In consequence, they can\nrepresent non-manifold situations, open and closed sets,\nmixed-dimensional complexes and they are closed under all boolean\nand topological operations, such as complement and boundary. They\nwere introduced by W. Nef in his seminal 1978 book on polyhedra.\n\nWe presented in previous work a new data structure for the boundary\nrepresentation of three-dimensional Nef polyhedra with\nefficient algorithms for boolean operations. These algorithms were\ndesigned for correctness and can handle all cases, in particular all\n\\emph{degeneracies}. To this extent we rely on exact\narithmetic to avoid well known problems with floating-point\narithmetic.\n \nIn this paper, we present important optimizations for the\nalgorithms. We describe the chosen implementations for the\npoint-location and the intersection-finding subroutines, a kd-tree\nand a fast box-intersection algorithm, respectively. We evaluate\nthis optimized implementation with extensive experiments that\nsupplement the runtime analysis from our previous paper and that\nillustrate the effectiveness of our optimizations. We compare our\nimplementation with the \\textsc{Acis} CAD kernel and demonstrate the power and\ncost of the exact arithmetic in near-degenerate situations.\n \nThe implementation was released as Open Source in the\n\\textsc{Cgal} release 3.1 in December 2004.
Genome-scale reconstruction and in silico analysis of Klebsiella oxytoca for 2,3-butanediol production (2013)

The genome-scale metabolic model, KoxGSC1457, constructed in this study successfully investigated metabolic characteristics of K. oxytoca at systems level. The KoxGSC1457 model could be employed as an useful tool to analyze its metabolic capabilities, to predict its physiological responses according to environmental and genetic perturbations, and to design metabolic engineering strategies to improve its metabolic performance.
High Energy Organic Cathode for Sodium Rechargeable Batteries (2015)

Organic electrodes have attracted significant attention as alternatives to conventional inorganic electrodes in terms of sustainability and universal availability in natural systems. However, low working voltages and low energy densities are inherent limitations in cathode applications. Here, we propose a high-energy organic cathode using a quinone-derivative, C6Cl4O2, for use in sodium-ion batteries, which boasts one of the highest average voltages among organic electrodes in sodium batteries (similar to 2.72 V vs Na/Na+). It also utilizes a two-electron transfer to provide an energy of 580 Wh kg(-1). Density functional theory (DFT) calculations reveal that the introduction of electronegative elements into the quinone structure significantly increased the sodium storage potential and thus enhanced the energy density of the electrode, the latter being substantially higher than previously known quinone-derived cathodes. The cycle stability of C6Cl4O2 was enhanced by incorporating the C6Cl4O2 into a nanocomposite with a porous carbon template. This prevented the dissolution of active molecules into the surrounding electrolyte.
Structure of the human hexabrachion (tenascin) gene. (1991)

The structure of the gene encoding human hexabrachion (tenascin) has been determined from overlapping clones isolated from a human genomic bacteriophage library. The genomic inserts were characterized by restriction mapping, Southern blot analysis, PCR, and DNA sequencing. The coding region of the hexabrachion gene spans approximately 80 kilobases of DNA and consists of 27 exons separated by 26 introns. The exon-intron structure supports a hypothesis based on the cDNA sequence that the hexabrachion gene is an assembly of DNA modules that are also found elsewhere in the genome. Single exons may encode a module, a portion of a module, or a group of modules. The 15 type III units similar to those found in fibronectin are each encoded either by a single exon or by two exons interrupted by an intron. All type III units known to be spliced out of the smaller forms of the protein are encoded by one exon. The fibrinogen-like domain of 210 amino acids is encoded by five exons. The 14.5 epidermal growth factor-like repeats are all encoded by a single exon.
Deposition of high dielectric constant materials by dual spectral sources assisted metalorganic chemical vapor deposition (1995)

The development of new high dielectric constant materials is essential for the development of advanced silicon integrated circuits. In this letter, we report preliminary results of lanthanum doped lead zirconate titanate (PLZT) films deposited by dual spectral sources (DSS) rapid isothermal processing (RIP) assisted metalorganic chemical vapor deposition (MOCVD) system. The dielectric constant and leakage current density data reported in this letter represents the best results reported to date. The use of high energy photons play an important role in the deposition of high quality dielectric films
En la frontera de la música y el teatro: el caso de Water Walk de John Cage (2017)

Este ensayo se propone discutir y explorar implicaciones conceptuales en relación a la pieza "Water Walk" de John Cage, su relación respecto de la idea de teatro y composición musical y la interrelación que presenta entre sonido y acción teatral. Aunque no se dispone de una respuesta final respecto de categorizar "Water Walk" en un género determinado, este escrito intenta establecer que la pieza presenta un carácter performático que la acerca más a una idea teatral y/o de arte de acción que a una composición musical.