gebhart/patrepeval huggingface dataset:
Fabrication of Assembled Virus Nanostructures on Templates of Chemoselective Linkers Formed by Scanning Probe Nanolithography (2003)

We have developed a multistep route to the fabrication of virus assembled nanostructures with chemoselective protein-to-surface linkers synthesized by an efficient solid-phase method. These linkers were used to create patterns of 30-to-50-nm-width-lines by scanning probe nanolithography. Genetically modified cow pea mosaic virus with unique cysteine residues at specific locations on their capsomers were assembled through covalent linkage on these patterns. The morphology of the assembled structures on these line patterns characterized by atomic force microscopy was found to be strongly influenced by the intervirion interactions.
Clinical Management of the Osteoporoses. (1977)

Gordan and Vaughn provide an up-to-date clinical review of a common problem in medical practice. In the first few chapters they deal with the definition of osteoporosis and with its relation to physical activity, aging, and hormone and endocrine function. Bone physiology and pathology is presented comprehensibly. Middle chapters carry a discussion of diagnostic tests and a rather lengthy review of quantitative measures of bone density. After discussing the main differential diagnosis of osteoporosis, the authors take up the major types of osteoporosis: postmenopausal osteoporosis, immobilization osteoporosis, and corticoid osteoporosis. Emphasis is on pathophysiology, diagnosis, and treatment. Various therapeutic regimens
Fast algorithm for creating image-based stereo images (2002)

The process that creates stereo images typically takes from 1.5 to 2 times longer than the algorithm for mono images. This paper presents a fast image-based algorithm for computing stereo images, that needs a little more time than the algorithm for mono images. The presented algorithm uses a single image with depth information (e.g. z-buffer) as an input and produces two images for left and right eye. This algorithm is a simplification of the 3D warping algorithm.
Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants (2014)

Antibody-mediated immunotherapy is effective in humanized mice when combinations of broadly neutralizing antibodies (bNAbs) are used that target nonoverlapping sites on the human immunodeficiency virus type 1 (HIV-1) envelope. In contrast, single bNAbs can control simian-human immunodeficiency virus (SHIV) infection in immune-competent macaques, suggesting that the host immune response might also contribute to the control of viremia. Here, we investigate how the autologous antibody response in intact hosts can contribute to the success of immunotherapy. We find that frequently arising antibodies that normally fail to control HIV-1 infection can synergize with passively administered bNAbs by preventing the emergence of bNAb viral escape variants.
Out‐of‐plane brachial plexus block with a novel Sonix <scp> GPS <sup>TM</sup> </scp> needle tracking system (2013)

We wish to report on our preliminary experience with a novel ultrasound guided needle-tracking system. After institutional ethics approval and written informed consent, a convenience sample of 15 patients was prospectively enrolled for out-of-plane interscalene, supraclavicular and infraclavicular brachial plexus blocks 1, 2. The SonixGPS™ (Ultrasonix, Richmond, BC, Canada) is an electromagnetic needle tracking system for ultrasound guided needle interventions that has been approved in Canada (Health Canada approval #86707, 86708 and 86709). It displays the current and predicted needle tip position in real-time on the ultrasound screen, thus facilitating needle-beam alignment and guidance to the target (Fig. 5). For all blocks, a 5-14 MHz linear transducer and 8-cm 19-G SonixGPS needles were used. All blocks were performed after pre-procedural scanning and local anesthetic infiltration along the intended needle path. At the point of injection of local anesthetic, the extrapolated needle tip was in close proximity to the brachial plexus. For all 15 injections, the brachial plexus was easily identified and an optimal ultrasound image was easily obtained (Fig. 6). During all maneuvers, the extrapolated needle position was seen clearly with all attempts and there was no loss of image with needle manipulation. Circumferential spread of local anesthetic in real time and its spatial relationship to the brachial plexus and the extrapolated needle tip position could be observed in all patients. At the time of injection, there was no evidence of deeper than anticipated needle penetration as judged by displacement of adjacent soft tissues. We conclude that real-time ultrasound guided out-of-plane brachial plexus blocks with needle guidance technology can be performed accurately and successfully in patients using the SonixGPS system.
Abstract 4044: microRNA mimics as cancer therapeutics (2010)

Abstract microRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally. The mRNA targets of microRNAs are usually determined based on complementarily to the 5′ end of the microRNA; the area termed the seed sequence. One microRNA can have more than 100 mRNA targets that are usually inhibited by ∼50%. The expression of microRNAs has been shown to be dysregulated in numerous cancer types. These dysregulated microRNAs can act to either positively or negatively regulate initiation, proliferation and metastasis of cancer cells. Some of the most important pathways in cancer biology (e.g. the Ras and p53 pathways) have been shown to interact with microRNAs. Therefore, both inhibiting and replacing microRNAs have therapeutic potential in oncology. We are using technology similar to that used for antisense oligonucleotides and lipid nanoparticle formulated siRNAs, both of which are currently in clinical trials for cancer, to determine the best potential microRNA based therapeutics to develop as drugs. In this report we will focus on our attempts to introduce mimics of microRNAs known to be down-regulated in tumors (e.g. miR-34a). Initial experiments were performed in wild-type mice and demonstrated the ability to deliver microRNA mimics to the liver and to affect gene expression in a seed sequence-dependent manner. These results, along with effects of successful microRNA introduction into an orthotopic xenograft model of hepatocellular carcinoma will be presented. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4044.
Elimination of Extinction Effects by Extrapolation to Zero Wavelength (1996)

A model-free approach to extinction correction of single-crystal reflection data has been developed. Single-crystal peak-intensity observations taken over a series of wavelengths in the range 0.25–0.11 Å were extrapolated to zero wavelength. Evaluation of this method by comparison of extrapolated values with accurate kinematic structure factors for Si shows that it is capable of giving approximate independent estimates of extinction effects. The accurate synchrotron data of Hester, Maslen, Spadaccini, Ishizawa & Satow [Acta Cryst. (1993), B49, 842–846], which those authors believed to be unaffected by extinction, has been checked using the present method and found to be significantly affected by extinction. The present results give no reason to doubt the validity of widely used extinction models.
Centriolar Satellites (1999)

We identified Xenopus pericentriolar material-1 (PCM-1), which had been reported to constitute pericentriolar material, cloned its cDNA, and generated a specific pAb against this molecule. Immunolabeling revealed that PCM-1 was not a pericentriolar material protein, but a specific component of centriolar satellites, morphologically characterized as electron-dense granules, approximately 70-100 nm in diameter, scattered around centrosomes. Using a GFP fusion protein with PCM-1, we found that PCM-1-containing centriolar satellites moved along microtubules toward their minus ends, i.e., toward centrosomes, in live cells, as well as in vitro reconstituted asters. These findings defined centriolar satellites at the molecular level, and explained their pericentriolar localization. Next, to understand the relationship between centriolar satellites and centriolar replication, we examined the expression and subcellular localization of PCM-1 in ciliated epithelial cells during ciliogenesis. When ciliogenesis was induced in mouse nasal respiratory epithelial cells, PCM-1 immunofluorescence was markedly elevated at the apical cytoplasm. At the electron microscopic level, anti-PCM-1 pAb exclusively labeled fibrous granules, but not deuterosomes, both of which have been suggested to play central roles in centriolar replication in ciliogenesis. These findings suggested that centriolar satellites and fibrous granules are identical novel nonmembranous organelles containing PCM-1, which may play some important role(s) in centriolar replication.
Cell-specific targeting of caveolin-1 to caveolae, secretory vesicles, cytoplasm or mitochondria (2001)

In commonly used tissue culture cells, caveolin-1 is embedded in caveolae membranes. It appears to reach this location after being cotranslationally inserted into ER membranes, processed in the Golgi and shipped to the cell surface. We now report that caveolae are not the preferred location for caveolin-1 in all cell types. Skeletal muscle cells and keratinocytes target caveolin-1 to the cytosol while in exocrine and endocrine cells it accumulates in the secretory pathway. We also found that airway epithelial cells accumulate caveolin-1 in modified mitochondria. The cytosolic and the secreted forms appear to be incorporated into a soluble, lipid complex. We conclude that caveolin-1 can be targeted to a variety of intracellular destinations, which suggests a novel mechanism for the intracellular traffic of this protein.
Compressible cavity flow oscillation due to shear layer instabilities and pressure feedback (1995)

A computational analysis was performed on a compressible flow oscillation due to shear layer instabilities over a cavity and pressure feedback in a cavity of length-to-depth ratio 3 at Mach 1.5 and 2.5. The mass-averaged Navier-Stokes equations were solved. Turbulence closure was achieved using a k-ω model withcompressibility corrections. Self-sustained oscillations were produced. Negative form drag coefficient was observed within an oscillatory cycle due to mass ejection from the cavity near the trailing edge and vortex production near the leading edge. The shock wave-expansion wave interaction patterns, modes of the oscillation, sound pressure level, and time-averaged surface pressure were compared with experimental results of previous investigations and good agreement was achieved, particularly the time-averaged pressure. The prediction showed a marked improvement over earlier analysis.
Determination of Cobalt in Soil, Steel, and Graphite Using Excited-State Laser Fluorescence Induced in a Laser Spark (1997)

An LIBS/LEAFS (laser-induced breakdown spectroscopy/laser-excited atomic Fluorescence spectrometry) combination with the use of simple open-air ultraviolet (UV) ablation has been investigated in terms of its analytical possibilities for the determination of cobalt in three solid sample matrices: graphite, soil, and steel. The fluorescence of cobalt was excited from a level which was already populated in the ablation plasma and was monitored at the Stokes-shifted wavelength. The optimal time delay between the ablating and exciting pulses was 16 μs. Detection limits in the ppb to ppm range and linearity over about four orders of magnitude were obtained. Excellent correlation of the LIBS/LEAFS with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and the certified value for Co in an SRM soil standard showed that both the precision and the accuracy of the LIBS/LEAFS method were satisfactory.
Recent insights into Protein Phosphatase 2A structure and regulation: the reasons why PP2A is no longer considered as a lazy passive housekeeping enzyme (2010)

Although intracellular signal transduction is often portrayed as a protein kinase "domino effect", the counterbalancing function of phosphatases, and thus the control of phosphatase activity, is equally relevant to proper regulation of cellular function. Protein Phosphatase 2A (PP2A) is a widely expressed family of protein phosphatases made of a core dimer, composed of a catalytic (C) subunit and a structural (A) subunit, in association with a third variable regulatory (B) subunit. Although viewed as a constitutive housekeeping enzyme in the past, PP2A is a highly regulated phosphatase and is emerging as an important regulator of multiple cellular processes involving protein phosphorylation. The regulation of PP2A is mainly accomplished by the identity of the regulatory B-type subunit, which determines substrate specificity, subcellular localization and catalytic activity of the PP2A holoenzyme. In agreement with this, recent findings on the structure and post-translational modifications of PP2A emphasize the importance of PP2A holoenzyme composition in its regulation and pleiotropic activities.
ChemInform Abstract: TRANSITION METAL REACTIONS OF SILANES. 3. OCTACARBONYLDICOBALT‐CATALYZED REACTIONS OF CYCLIC ETHERS WITH HYDROSILANES AND CARBON MONOXIDE (1978)

Abstract Die silylgeschützten Hydroxyaldehyde (II) und (IV) werden aus den cyclischen Ethern (I) bzw. (III) durch Behandlung mit Diethylmethylsilan und CO in Gegenwart katalytischer Mengen Octacarbonyldicobalt im Autoklaven direkt und in brauchbaren Ausbb.
Mineral acquisition by maize grown in acidic soil amended with coal combustion products (2001)

Large amounts of coal combustion products (CCPs) are produced when coal is burned for generation of electricity. Some of these CCPs could potentially be used as soil amendments, and information about their effects on plant mineral nutrition is needed. Glasshouse experiments were conducted to test the effects of different levels of 15 CCPs and chemical grade CaCO3, CaSO4, and CaSO3 added to acidic soil (Umbric Dystrochrept) on shoot calcium (Ca), sulfur (S), phosphorus (P), potassium (K), magnesium (Mg), manganese (Mn), iron (Fe), zinc (Zn), copper (Cu), and aluminum (Al) concentrations of maize (Zea mays L.). The CCPs consisted of two fly ashes (FAs), one CaO material, three fluidized bed combustion products (FBCs), three “non-stabilized” flue gas desulfurization products (FGDs), three “stabilized” FGDs, and three “oxidized” (FGD gypsum) FGDs. Level of CCP added to soil ranged from beneficial to detrimental effects on plants. Differences in shoot mineral element concentrations were related to kind and amount of CCP added and soil pH. Plants grown in unamended (pH 4) soil had symptoms of P and Mg deficiencies and Al toxicity. High concentrations of Ca, S, Mg, and Mn accumulated when plants were grown with some CCPs, but most mineral nutrients were at concentrations considered normal for maize. Shoot concentrations of P, K, Zn, Mn, Fe, and Al decreased when soil pH became high (>7). Even though detrimental mineral element acquisition effects were imposed on plants at high levels of CCP application, shoot element concentrations were usually normal when applied at levels near those commonly used as soil amendments.
Structure and Catalytic Properties of Pd/10Al2O3·2B2O3. Effect of Preparation Routes and Additives (2012)

Abstract The synthesis route of 10Al2O3·2B2O3 (10A2B) and effect of additives were studied to use this compound as a thermally stable support material for Pd catalysts. The preparation by reverse coprecipitation was found to have a beneficial effect on the BET surface area of 10A2B and thus Pd metal dispersion, compared to other preparation routes via solid-state reaction and hydrolysis of metal alkoxides. The addition of 3 wt % BaO suppressed the sintering of 10A2B and Pd during thermal aging at 900 °C in a stream of air containing 10% H2O. Although direct interactions between Pd and the support material were not detected by EXAFS, the catalytic performance for NO–CO–C3H6–O2–H2O reactions under modulated air-to-fuel ratio (A/F) conditions was strongly influenced by the Ba additive. The activity for NO and C3H6 in a rich region (A/F &lt; 14.6) was especially enhanced in the presence of Ba because of accelerated elemental reactions including NO–CO and NO–C3H6. In situ FT-IR of CO suggested that the Pd electronic state changed by electrostatic effect of Ba additives would activate NO and weaken the self-poisoning effect of C3H6.
Acoustic Eavesdropping through Wireless Vibrometry (2015)

Loudspeakers are widely used in conferencing and infotainment systems. Private information leakage from loudspeaker sound is often assumed to be preventable using sound-proof isolators like walls. In this paper, we explore a new acoustic eavesdropping attack that can subvert such protectors using radio devices. Our basic idea lies in an acoustic-radio transformation (ART) algorithm, which recovers loudspeaker sound by inspecting the subtle disturbance it causes to the radio signals generated by an adversary or by its co-located WiFi transmitter. ART builds on a modeling framework that distills key factors to determine the recovered audio quality. It incorporates diversity mechanisms and noise suppression algorithms that can boost the eavesdropping quality. We implement the ART eavesdropper on a software-radio platform and conduct experiments to verify its feasibility and threat level. When targeted at vanilla PC or smartphone loudspeakers, the attacker can successfully recover high-quality audio even when blocked by sound-proof walls. On the other hand, we propose several pragmatic countermeasures that can effectively reduce the attacker's audio recovery quality by orders of magnitude.
Nanomaterial‐Enabled Wearable Sensors for Healthcare (2017)

Highly sensitive wearable sensors that can be conformably attached to human skin or integrated with textiles to monitor the physiological parameters of human body or the surrounding environment have garnered tremendous interest. Owing to the large surface area and outstanding material properties, nanomaterials are promising building blocks for wearable sensors. Recent advances in the nanomaterial-enabled wearable sensors including temperature, electrophysiological, strain, tactile, electrochemical, and environmental sensors are presented in this review. Integration of multiple sensors for multimodal sensing and integration with other components into wearable systems are summarized. Representative applications of nanomaterial-enabled wearable sensors for healthcare, including continuous health monitoring, daily and sports activity tracking, and multifunctional electronic skin are highlighted. Finally, challenges, opportunities, and future perspectives in the field of nanomaterial-enabled wearable sensors are discussed.
Ventricular Fibrillation Scaling Exponent Can Guide Timing of Defibrillation and Other Therapies (2004)

VF of brief to moderate duration is effectively treated by IC. When VF is prolonged, as indicated by an ScE of 1.3 or greater, IC was not effective and delayed time to ROSC. The ScE can help in choosing the first intervention in the treatment of VF.
A helical face-sharing tetrahedron chain from irrational twist, stella quadrangula, and related matters (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA helical face-sharing tetrahedron chain from irrational twist, stella quadrangula, and related mattersChong Zheng, Roald Hoffmann, and David R. NelsonCite this: J. Am. Chem. Soc. 1990, 112, 10, 3784–3791Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/ja00166a012https://doi.org/10.1021/ja00166a012research-articleACS PublicationsRequest reuse permissionsArticle Views330Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Diels‐Alder‐Reaktionen mit Terpenketonen (1967)

Abstract Carvon bildet mit acyclischen Dienen Derivate des 9‐Methyl‐3‐isopropenyl‐Δ6‐ cis ‐octalons‐(1) (3) , die z. T. getrennt und sterisch zugeordnet werden. Pulegon ergibt Derivate des 5.5.9‐Trimethyl‐spiro[5.5]undecen‐(2)‐ons‐(7) (8) , die ebenfalls in geometrischen Isomeren auftreten.
Oversampled timing recovery for magnetic recording channels (2004)

In this paper, oversampled timing recovery for magnetic recording channels. Performance comparison using PLL gain parameters were designed. We consider normalized recording density for both longitudinal and perpendicular recording channels with media jitter noise, clock jitter noise, and frequency offset were modelled.
ICT활용교육 위한 웹코스웨어 평가 및 개선방안 연구 : 자료제시형 중심 (2003)

7차 교육과정은 21세기 정보사회에 ICT활용능력을 신장하고 웹의 교육적 가능성을 활용하여 수업
방법을 개선하고자 초등교육에 ICT활용교육을 10%이상 필수화하였다. 이러한 ICT활용교육을 지원
하기 위해 정책적으로 초등 교과교육을 위한 코스웨어 개발․보급에 막대한 예산과 노력을 투자하여
국가기관, 시․도 교육청, 그리고 기업 중심으로 웹코스웨어 개발․보급이 활발히 진행되어 왔으며
앞으로 더욱 빠르게 확대 될 전망이다.
한편, 이렇게 빠른 속도로 확대되고 있는 웹코스웨어 개발․보급의 투자가치와 활용효과를 확인하기 위해서는 사용자인 교사와 학생들의 직접적인 활용경험을 기초로 평가가 이루어져야 할 것이다.
그러나 지금까지는 국가 및 민간업체 모두 웹코스웨어의 개발과 보급에 치우치고 적용 및 평가연구는 매우 소홀히 하는 실정이다. 따라서 본 연구는 지금까지 개발된 초등교육 웹코스웨어를 교사 중심으로 교수-학습 측면의 효과를 심층적 분석․평가해보고 이를 기초로 문제점 지적과 현장중심 설계 개선 방안을 제시하고자 하였다.
연구대상은 초등학교 정보부서 관련업무를 맡고 있거나 수업에 웹코스웨어 적용 경험이 많은 교사133명을 선정하였다. 평가대상 웹코스웨어는 자료제시형태 웹코스웨어로 한정하였다. 자료제시형 웹
코스웨어를 제공하는 전체 8사이트에서 고학년 주교과(국, 수, 사, 과) 중심으로 41편의 웹코스웨어를 선정하여 각 프로그램별로 3-5명의 교사들이 평가를 하였다. 직접 수업에 적용해 본 경험을 기초로 다시 개별적으로 웹코스웨어를 검토해 보며 자료제시형 웹코스웨어 평가설문지(노명숙, 이미자,박선주(2001)를 이용하여 평가하였다. 평가 및 자료수집은 2001년 3～7월과 2002년 5～7월에 실시되었다.
본 연구 결과 지금까지 개발된 자료제시형 웹코스웨어들에 대한 초등교사들의 평가는 대체로 만족스럽지 못한 것으로 나타났다. 이러한 웹코스웨어들은 교수-학습 효과 및 활용 측면에 많은 문제를 가지고 있고 결과적으로 초등 현장 수업개선에 크게 기여하지 못하고 있음을 시사하였다. 이러한 불만족한 결과의 가장 큰 원인으로 자료제시형 웹코스웨어들이 대량으로 서둘러 개발․보급되었으나 학교의 실제 교수-학습상황을 제대로 반영하지 못한 점을 지적하였다. 교수-학습상황을 제대로 반영하지 못한 여러 가지 구체적인 문제점 지적과 이러한 문제점을 개선하기 위한 설계대안들을 제시하였다. 본 연구결과는 특히 최근 들어 사회 전반적으로 ICT활용교육을 위한 웹코스웨어 개발․보급을 급진적으로 확대하고 있는 시점에서 지금까지 개발된 자료제시형 웹코스웨어들에 대한 중간 점검평가 및 앞으로의 새로운 설계․개발․보급 계획 및 정책수립을 위한 참고자료가 될 수 있을 것이다.
A survey of ciguatera at Enewetak and Bikini, Marshall Islands, with notes on the systematics and food habits of ciguatoxic fishes (1980)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.