gebhart/patrepeval huggingface dataset:
The relationship between chemical structure and effectiveness of some metallic dialkyl‐ and diaryl‐dithiophosphates in different lubricated mechanisms (1992)

Abstract The antiwear (AW) and extreme‐pressure (EP) properties of some metallic dialkyl‐ and diaryldithiophosphates (MDTP), including zinc, have been studied in different metal/metal contact conditions: four‐ball and FZG rigs. It was noted that with pure dialkyldithiophosphates of different divalent metals (Zn, Cd, Cu, Pb, Ni, Co), prepared from the same alcohol, four‐ball, EP results, expressed in terms of load‐wear index, show that the highest performances are obtained with ZnDTP, but, statistically, the higher the ionic radius of the metal, the better the performance, while EP results, expressed in terms of weld load, do not show any difference between the MDTPs. Four‐ball AW results, expressed in terms of wear scar, show that the highest performances are obtained with ZnDTPs; beyond a certain value these performances with Zn and Pb are almost independent of the concentration. For the other metallic DTPs, there is a very close relationship between performance and concentration. On the FZG gear rig, EP‐AW results, expressed in terms of failure load stage and specific wear, show that statistically, the higher the ionic radius of the metal, the better the performance. With ZnDTP four‐ball, EP results, expressed in terms of load wear index, do not depend on the chemical structure of the alcohol used for synthesised ZnDTP, but, if results are expressed in terms of weld load, better performances are obtained with ZnDTP synthesised from secondary alcohols. AW results show that the effectiveness of ZnDTP from secondary alcohols is slightly higher when the alcohols used contain less than six carbon atoms. Beyond six carbon atoms in primary or secondary alcohol molecules, performances decrease. FZG, EP‐AW results show that performance does not depend on the primary or secondary nature of the alcohols used, and that the smaller the hy‐.
Characterization of DNA‐protein complexes induced in intact cells by the carcinogen chromate (1988)

Potassium chromate induced the formation of DNA-protein complexes in cultured Chinese hamster ovary cells. The DNA-protein complexes were isolated by ultracentrifugal sedimentation in the presence of 2% sodium dodecyl sulfate (SDS) and 5 M urea. Two-dimensional SDS-polyacrylamide gel electrophoresis analysis of the chromate-induced DNA-protein complexes revealed that two acidic proteins of 53 and 45 kDa and a basic protein of 54 kDa were selectively complexed to the DNA. Numerous other proteins also became associated with the DNA to a lesser degree as the chromate concentration was increased. Nuclease digestion was not a prerequisite for the resolution of the protein component of the DNA-protein complexes using two-dimensional gel electrophoresis. Ultracentrifugal analysis of the DNA-protein complexes in the presence of proteinase K, nucleases, or a chelating agent demonstrated that protein aggregation was not responsible for the increased protein recovery in chromate-treated samples and that the complexes were disrupted by EDTA. These data suggest that the selectively complexed proteins were associated with the DNA through strong interactions that may be mediated by the trivalent form of chromium.
Hypoxia Induces Dilated Cardiomyopathy in the Chick Embryo: Mechanism, Intervention, and Long-Term Consequences (2009)

Our data show that hypoxia causes a decreased cardiac performance and cardiomyopathy in chick embryos, involving a significant VEGF-mediated component. This cardiomyopathy persists into adulthood.
DPillar: Scalable Dual-Port Server Interconnection for Data Center Networks (2010)

Data centers are becoming increasingly important infrastructures for many essential applications such as data intensive computing and large-scale network services. A typical future data center can consist of up to hundreds of thousands of servers. Yet, the conventional data center networks are not able to keep up with the network bandwidth requirement for efficiently connecting that huge number of servers in a cost-efficient manner. In this paper, we present DPillar, a highly scalable data center interconnection architecture, which uses only low-end off-the-shelf commodity PC servers and switches. DPillar has minimal requirements for the equipment. The switches are low-cost plug-and-play layer-2 devices and servers are dual-port commodity PCs. The salient feature of DPillar is that it expands to any number of servers without requiring to physically upgrade the existing servers. We present simple yet efficient routing schemes for DPillar and evaluate the routing performance via simulations.
Deux problèmes d'ordonnancement en télécommunications par satellite (1991)

avec les conditions gnrales d'utilisation (http://www.numdam.org/
<title>Performance of MPEG codecs in the presence of errors</title> (1993)

MPEG is emerging as a major international standard for applications in compressed video storage, transmission, and interactive communications. MPEG will be used in applications which involve imperfect channel conditions or storage defects. This work studies the effects of different types of errors on the compressed MPEG bit streams and possible approaches to minimize such effects. The use of forward error correction, block interleaving, error concealment, and their inter-relationship and applicability to MPEG bit streams, were investigated.
Bayesian Belief Network Model for the Safety Assessment of Nuclear Computer-based Systems (1997)

The formalism of Bayesian Belief Networks (BBNs) is being increasingly applied to probabilistic modelling and decision problems in a widening variety of fields. This method provides the advantages of a formal probabilistic model, presented in an easily assimilated visual form, together with the ready availability of efficient computational methods and tools for exploring model consequences. Here we formulate one BBN model of a part of the safety assessment task for computer and software based nuclear systems important to safety. Our model is developed from the perspective of an independent safety assessor who is presented with the task of evaluating evidence from disparate sources: the requirement specification and verification documentation of the system licensee and of the system manufacturer; the previous reputation of the various participants in the design process; knowledge of commercial pressures;information about tools and resources used; and many other sources. Based on these multiple sources of evidence, the independent assessor is ultimately obliged to make a decision as to whether or not the system should be licensed for operation within a particular nuclear plant environment. Our BBN model is a contribution towards a formal model of this decision problem. We restrict attention to a part of this problem: the safety analysis of the Computer System Specification documentation. As with other BBN applications we see this modelling activity as having several potential benefits. It employs a rigorous formalism as a focus for examination, discussion, and criticism of arguments about safety. It obliges the modeller to be very explicit about assumptions concerning probabilistic dependencies, correlations, and causal relationships. It allows sensitivity analyses to be carried out. Ultimately we envisage this BBN, or some later development of it, forming part of a larger model, which might well take the form of a larger BBN model, covering all sources of evidence about pre-operational life-cycle stages. This could provide an integrated model of all aspects of the task of the independent assessor, leading up to the final judgement about system safety in a particular context. We expect to offer some results of this further work later in the DeVa project.
Analysis of The Flow‐Through Porous Trielectrode Reactor (1983)

The limiting current analysis has been applied to a flow‐through porous electrode with two counterelectrodes. The electric driving force variation through the working electrode can be minimized by adjusting the fraction of the total current that passes through each counterelectrode. For applications with a maximum acceptable ohmic potential drop in the reactor, the use of two counterelectrodes can substantially increase the maximum processing rate for a flow‐through reactor and hence make it more competitive with the flow‐by electrode configuration.
Selecting the best web service (2004)

Web services are applications that communicate over open protocols such as HTTP using structured forms of XML such as the Simple Object Access Protocol (SOAP) or Remote Procedure Calls for XML (XML-RPC). The success of web services is largely based on the continuous development of standards that ensure interoperability. Among the many standards developed and widely accepted are: the Web Service Description Language (WSDL), used for describing web services' syntax; and the Universal Description, Discovery and Integration protocol (UDDI), often used as a discovery mechanism for dynamically finding new services. However, there have been fewer efforts to describe the interactions between clients and services. This paper focuses on augmenting web service clients as a means for determining optimal service providers. A system is discussed and analyzed for using the Resource Description Framework (RDF), the Java Expert Systems Shell (JESS), WEKA, and the Web Ontology Language (OWL) to augment web service clients. The clients can collect, report, and analyze data about their experiences with the quality of service (QoS) of web services, as well as their own system context information. The clients are able to parse and use the reported information to dynamically select the best service for their needs, to re-configure themselves to use the new service, and continue operation transparently.
Synthesis and metabolic fate of hesperetin-3-14C (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and metabolic fate of hesperetin-3-14CThomas Honohan, Ron L. Hale, Joseph P. Brown, and Robert E. Wingard Jr.Cite this: J. Agric. Food Chem. 1976, 24, 5, 906–911Publication Date (Print):May 1, 1976Publication History Published online1 May 2002Published inissue 1 May 1976https://pubs.acs.org/doi/10.1021/jf60207a031https://doi.org/10.1021/jf60207a031research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Update on Antifolate Drugs Targets (2001)

Antifolate drugs are molecules directed to interfere with the folate metabolic pathway at some level. They can be recognized among the first rationally designed compounds applying the principle of structural analogy with the substrate developing the antimetabolite strategy. This strategy has taken advantage of the basic different features of the microbial and human folate metabolism and therefore allows targeting the pathway at different steps generating a specificity tools for Medicinal Chemists. Two main problems are giving renewed importance to such targets and therefore improving the efforts to discover new targets in the folate metabolism area. The first one is the increasing resistance to the present drugs due to different mechanisms such as the enzyme modification and the increased production of enzymes with not well recognized importance. The second one is the development of techniques directed to highlight the interference at genetic level of molecular probes as antifolate drug to develop new enzymes previously unknown. This approach is defined as genetic approach to drug discovery, from gene to drugs. The present article describes the importance in drug design and discovery of some antifolate targets among the best known at the present status of research such as thymidylate synthase (TS), dhydrofolate reductases, (DHFR) serine hydroxymethyltransferase (SHMT), folyilpolyglutamyl synthetase (FPGS), gamma-glutamyl hydrolase (gamma-GH), glycinamide-ribonucleotide transformylase (GARTfase), amino-imidazole-carboxamide-ribonucleotide transformylase (AICARTfase) and Folate transporters. Discovery, known functions, structure/function studies and inhibition will be described.
Analysis of Drivers’ Eye-Movement Characteristics When Driving around Curves (2015)

To investigate drivers’ visual strategies and the distribution of fixation points, much work had been done and salient conclusions had been drawn. However, there is still no consensus on what the gaze target is and what functional significance the point might have. To improve theories on this subject, research was done to investigate drivers’ visual characteristics. On-road experiment was carried out, and drivers’ eye-movement and vehicle driving parameters were registered when driving around left- and right-hand curves. The results showed that drivers’ gaze direction fluctuates around the reference axis, and the fixation points are distributed in the region centered on the horizontal gaze position rather than a particular point that has geographical meanings. With the consideration of the traffic rules in China, we suggest here that there is no particular point on which drivers concentrate. Any point or position that could indicate the bend’s curvature could be the so-called target point. Drivers just want to operate their vehicle so as to pass through bends safely in a comfortable and labor-saving way.
Microcellular handoff control using robust prediction techniques (2003)

A new handoff schedule based on user mobility patterns and signal strength prediction for microcellular wireless networks is proposed. The signal strength prediction is based on the least mean square (LMS) adaptation algorithm and user mobility pattern is determined by a heuristic next-cell prediction technique. The handoffs previously performed can be used to predict the next visited cell of the user, once adequate information regarding past mobility patterns are available. In addition, signal strength-based prediction on the selected next-cell can aid in reduction of unnecessary handoffs to neighboring cells, not in the routine path of the user. Results show a significant reduction in the mean number of handoffs by the proposed combined prediction scheme.
TEMPO-Induced Generation of Alkyl Radicals from <i>B</i>-Alkylcatecholboranes (1999)

B-alkylcatecholboranes react efficiently with 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) to give alkyl radicals. In the presence of an excess of TEMPO, the generated radicals are efficiently converted to alkoxyamine derivatives.
Critical incident debriefing in groups: a group analytic perspective (2001)

This paper looks at providing critical incident debriefing in groups. It outlines key group analytic concepts that are relevant to debriefing, including mirroring, group dynamics and supervision. It details how these concepts, along with the facilitator's and supervisor's free-floating attention, can help in thinking about the group and the organizational impact on the individual and the group. Using examples of debriefing, suggestions are made about how to use these concepts within the debriefing session and the impact of the dynamics of the organization on the debriefing. The paper emphasizes the importance of supervision for debriefers and how the dynamics of the debriefing and the organizational context can be mirrored in the supervision. It illustrates the interplay between the individual, the group and the organization through commentary on vignettes, which include a debriefing session and the subsequent supervision session for debriefers.
Propofol—fentanyl anaesthesia for coronary artery surgery and cardiopulmonary bypass (1989)

A two-stage propofol infusion combined with fentanyl was used to maintain anaesthesia during coronary artery surgery in patients with good ventricular function. Whole blood propofol concentrations were measured at frequent intervals; plasma protein binding was measured before, during and after cardiopulmonary bypass. An initial infusion rate of 10 mg/kg/hour provided good protection from the pressor response to sternotomy. A predictable steady state concentration was achieved in the prebypass period with a maintenance infusion rate of 3 mg/kg/hour. The onset of bypass resulted in a small decrease in propofol concentration as a result of haemodilution. Induced hypothermia resulted in an increase in propofol concentration which returned rapidly to the prebypass steady state value during rewarming. The free propofol fraction increased during cardiopulmonary bypass. No patient had any recall of operative events or required inotropic support during weaning from bypass.
Ultraviolet laser-based communication system for short-range tactical applications (1994)

Solar blind ultraviolet communication techniques have promise to address the military's needs for short range applications where non-line-of-sight and a low probability of interception and detection is required. This paper addresses the general requirements for these systems and discusses an example system developed using a compact quadrupled Nd:YAG laser.
Apolipoprotein A-IV synthesis in rat intestine: regulation by dietary triglyceride (1987)

Apolipoprotein A-IV (apoA-IV) synthesis rates were measured in vivo in rat enterocytes by immunoprecipitation after administration of [3H]leucine into in situ loops of jejunum and ileum. Basal apoA-IV synthesis rates (percent total protein synthesis) were significantly higher in jejunal enterocytes (2.05 +/- 0.54%) compared with ileal enterocytes (0.48 +/- 0.32%) from the same fasted animals. After an acute triglyceride bolus, significant and sustained elevations of apoA-IV synthesis rates were seen in both jejunal and ileal enterocytes with maximal effects noted at 4-6 h. Animals fed diets containing 30% wt/wt triglyceride as saturated (SF) or polyunsaturated (UF) fats for 6 wk had similarly increased rates of apoA-IV synthesis in jejunal enterocytes with both SF (3.73 +/- 0.83%) and UF (3.33 +/- 0.64%) but no change in ileal enterocytes. By contrast, animals consuming a fat-free diet for 3 wk had jejunal apoA-IV synthesis rates indistinguishable from basal values (2.40 +/- 0.45%). Translatable intestinal mRNA levels for pre-apoA-IV after triglyceride increased in parallel to synthesis rates with a 50% increase in jejunum and a 350% increase in ileum observed at 4-6 h. These results suggest that apoA-IV synthesis by rat small intestine increases in response to acute and chronic dietary triglyceride, is maintained in the absence of dietary triglyceride, and may be under pretranslational control.
Colorectal neoplasia (1991)

There has undoubtedly been progress in our management of both primary and advanced or recurrent colorectal cancer. Surgery remains the mainstay and most important modality. However, adjuvant therapy for patients thought to have had a “curative” resection may be beneficial. Promising approaches include systemic treatment involving 5-fluorouracil in conjunction with levamisole and portal-vein infusion in conjunction with 5-fluorouracil. In addition, radiotherapy has been shown to reduce local recurrence rates. For advanced or recurrent disease, several novel approaches are beginning to show promise, including enhancement of the effect of 5-fluorouracil by biochemical modulation with, for example, leucovorin. In addition, the combination of immunotherapy with chemotherapy may result in an enhanced response. These approaches deserve further study.
Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson's disease (2005)

The peduncolopontine nucleus modulates locomotor activity and dysfunction in this nucleus may be responsible for the gait and postural impairments seen in Parkinson's disease and other movement disorders. We report the first surgical exploration and implantation of deep brain stimulating electrodes of the peduncolopontine nucleus area in two Parkinson's disease patients to examine the safety and the potential benefit of chronic electrical stimulation at this site. Under local anesthesia, the peduncolopontine nucleus was approached from a coronal burr hole using a trajectory that was 78-80 degrees and 62-64 degrees on the coronal and sagittal planes. Microrecordings helped to identify neurons in peduncolopontine nucleus and the adjacent substantia nigra pars reticulata. Chronic deep brain stimulating electrodes were implanted within the peduncolopontine nucleus in a manner similar to that practiced with deep brain stimulating surgery at other targets. Peduncolopontine nucleus neurons were characterized by small and broad multiunits (230 muV, 2.5 ms, 14.6 Hz). Caudal to this area, neurons firing at higher frequency, approximately 70 Hz, characteristic of nigral neuronal discharges, were encountered, followed by 2 mm of cells similar to those recorded in the dorsal peduncolopontine nucleus area. After deep brain stimulating electrodes implantation, acute intraoperative stimulation (up to 3 V) was performed with two stimulation frequencies in each session. Stimulation at 80 Hz has little discernable effect. On the other hand, stimulation at 10 Hz fostered a subjective feeling of 'well-being' and a time-locked amelioration of the clinical scores. These findings demonstrate that the stereotactic approach of peduncolopontine nucleus is safe. The target may reliably be identified by microrecordings. Low-frequency stimulation may produce acute improvements in motor function.
Calibrating the Six-Port Reflectometer (2005)

Because complex heterodyne methods may be replaced by simple amplitude detectors, the six-port technique promises to have a major impact on the next generation of automatic network analyzers. This projection, however, is predicated upon the existence or development of calibration techniques which permit one to conveniently and accurately obtain the parameters which characterize the six-port. This paper describes a number of substantial refinements to a previously described procedure which is based upon the use of sliding terminations.