gebhart/patrepeval huggingface dataset:
Reaction of Astaxanthin with Peroxynitrite (2008)

The in vitro reactivities of astaxanthin toward peroxynitrite were investigated and the reaction products after scavenging with peroxynitrite were analyzed in order to determine the complete mechanism of this reaction. A series of carotenoids, 13-apo-astaxanthinone (1), 12'-apo-15'-nitroastaxanthinal (2), 12'-apo-astaxanthinal (3), 10'-apo-astaxanthinal (4), 9-cis-14'-s-cis-15'-nitroastaxanthin (5), 14'-s-cis-15'-nitroastaxanthin (6), 13-cis-14'-s-cis-15'-nitroastaxanthin (7), 10'-s-cis-11'-cis-11'-nitroastaxanthin (8), 13,15,13'-tri-cis-15'-nitroastaxanthin (9), 9-cis-astaxanthin (10), and 13-cis-astaxanthin (11), were isolated from the reaction products of carotenoids with peroxynitrite. Our previous studies achieved for the first time the isolation of nitro derivatives from the reaction of astaxanthin with peroxynitrite. Here we identify the major remaining reaction products of this reaction and investigate the stabilities of the nitro astaxanthins.
TREK-2, a New Member of the Mechanosensitive Tandem-pore K+ Channel Family (2000)

Recently, several mammalian K(+) channel subunits (TWIK, TREK-1, TRAAK, and TASK) possessing four transmembrane segments and two pore-forming domains have been identified. We report the cloning of a new member of this tandem-pore K(+) channel from a rat cerebellum cDNA library. It is a 538-amino acid protein and shares 65% amino acid sequence identity with TREK-1. Therefore, the new clone was named TREK-2. Unlike TREK-1, whose mRNA has been reported to be expressed in many different tissues, TREK-2 mRNA is expressed mainly in the cerebellum, spleen, and testis as judged by reverse transcriptase-polymerase chain reaction and Northern blot analysis. Expression of TREK-2 in COS-7 cells induced a time-independent and non-inactivating K(+)-selective current. TREK-2 was partially blocked (36%) by 2 mm Ba(2+). In symmetrical 150 mm KCl, the single-channel conductances were 110 picosiemens at -40 mV and 68 picosiemens at +40 mV, and the mean open time was 0.9 ms at -40 mV. TREK-2 was activated by membrane stretch or acidic pH. At -40 mm Hg pressure, channel activity increased 10-fold above the basal level. TREK-2 was also activated by arachidonic acid and other naturally occurring unsaturated free fatty acids. These results show that TREK-2 is a new member of the tandem-pore K(+) channel family and belongs to the class of mechanosensitive and fatty acid-stimulated K(+) channels.
Phase I Clinical Trial of the Inosine Monophosphate Dehydrogenase Inhibitor Mycophenolate Mofetil (Cellcept) in Advanced Multiple Myeloma Patients (2004)

MMF at 1 to 5 g/day daily dose is well tolerated by patients with relapsed and refractory multiple myeloma patients. Positive correlation between clinical response and depletion of intracellular dGTP level was shown. Future drug development to target this enzyme maybe useful in treating myelomas.
A Novel Cautery Instrument for On-Site Fenestration of Aortic Stent-Grafts: A Feasibility Study of 18 Patients (2013)

This simple-to-use instrument makes on-site creation of aortic stent-graft fenestrations easy, accurate, and precise. The instrument is inexpensive, robust, and easily sterilized.
Neutral Hydrogen in M31. V. The Formation Rate of HII Regions and a Correction Factor for the Star Formation Rate (1984)

Abstract The relation among the densities of H II regions (ρH II), young stars (ρ*), and H I gas (ρH I) in M31 is reexamined. We find a power-law relation among them as ρH II/ρH Im, where K is a constant and the value of index m is about 0.9. We point out that the “star formation rate” derived from the densities of H II regions and H I gas does not represent the true rate. The power index nH II derived from H II regions (ρH II ∝ ρH InH II) must be corrected for the excess m to obtain the power index n* of star formation rate (ρ* ∝ ρH In*) as n* = nH II – m, The value of n* derived for several galaxies is 0.8±0.1.
Thauera and Azoarcus as functionally important genera in a denitrifying quinoline-removal bioreactor as revealed by microbial community structure comparison (2005)

Structural shifts associated with functional dynamics in a bacterial community may provide clues for identifying the most valuable members in an ecosystem. A laboratory-scale denitrifying reactor was adapted from use of non-efficient seeding sludge and was utilized to degrade quinoline and remove the chemical oxygen demand. Stable removal efficiencies were achieved after an adaptation period of six weeks. Both denaturing gradient gel electrophoresis profiling of the 16S rRNA gene V3 region and comparison of the 16S rRNA gene sequence clone libraries (LIBSHUFF analysis) demonstrated that microbial communities in the denitrifying reactor and seeding sludge were significantly distinct. The percentage of the clones affiliated with the genera Thauera and Azoarcus was 74% in the denitrifying reactor and 4% in the seeding sludge. Real-time quantitative PCR also indicated that species of the genera Thauera and Azoarcus increased in abundance by about one order of magnitude during the period of adaptation. The greater abundance of Thauera and Azoarcus in association with higher efficiency after adaptation suggested that these phylotypes might play an important role for quinoline and chemical oxygen demand removal under denitrifying conditions.
Distributed wireless stereo reconstruction (1997)

In this paper we present new algorithms and experimental results from a system that performs efficient stereo reconstruction in bandwidth-constrained environments. This new approach is intended for a framework where sensors are connected via a wireless link to a high-speed network of workstations. The algorithms for object reconstruction from stereo correspondence achieve efficiencies by processing the image stream while it is still compressed, exploiting the compression process that is necessary for maximizing throughput on the wireless link.
Folded gate LDMOS transistor with low on-resistance and high transconductance (2001)

In this paper, a novel folded gate LDMOS transistor (FG-LDMOST) structure is proposed with the properties of low on-resistance and high transconductance. The FG structure is formed by adding a single trench process into the conventional LDMOS process. In this way, the channel density can be largely increased after the additional process. From the data by laboratory measurement, with the FG concept applied, the specific on-resistance of FG-LDMOS device is reduced by 45.66% compared to the conventional LDMOS structure with similar dimensions. At the same time, the transconductance value is improved by 64.09%. The capacitance and effective channel mobility for both FG-LDMOST and the counterpart are also measured and compared. The significance of the FG concept can also be applied in making CMOS and other MOS-gated devices in low to medium operating voltage ranges.
Injection of a magnetic domain wall into a submicron magnetic wire (1999)

Two types of magnetic wires (150 nm width) with trilayer structure consisting of NiFe (20 nm)/Cu (20 nm)/Co (20 nm) were prepared. One was connected to a square pad (0.5×0.5 μm2) at one end, while the other has a symmetrical shape with two flat ends. Magnetization reversal was detected sensitively by magnetoresistance measurement. Switching field of the Co layer for the wire with a pad was much smaller than that for the wire without a pad. This indicates that a domain wall nucleates initially in the pad and is injected into the wire at the switching field. This model for the magnetization reversal process is supported by the angular dependence of the switching field.
Molecular Interactions of Dendrimers with Amyloid Peptides:  pH Dependence (2006)

The formation of amyloid plaques is a key pathological event in neurodegenerative disorders, such as prion and Alzheimer's diseases. Dendrimers are considered promising therapeutic agents in these disorders. In the present work, we have studied the effect of polypropyleneimine dendrimers on the formation of amyloid fibrils as a function of pH in order to gain further insight in the aggregation mechanism and its inhibition. Amyloid fibrils from prion peptide PrP 185-208 and Alzheimer's peptide Abeta 1-28 were produced in vitro, and their formation was monitored using the dye thioflavin T (ThT). The results showed that the level of protonation of His, Glu, and Asp residues is important for the final effect, especially at low dendrimer concentration when their inhibiting capacity depends on the pH. At the highest concentrations, dendrimers were very effective against fibril formations for both prion and Alzheimer's peptides.
Positive Lightning Peak Currents Reported by the U.S. National Lightning Detection Network (2013)

We infer peak currents from radiation electric field peaks of 48 positive return strokes acquired in Gainesville, FL, USA, from 2007 to 2008. In doing so, we use the transmission line model, National Lightning Detection Network (NLDN) -reported distances, and assumed return-stroke speed. From a similar analysis of negative subsequent strokes, it appears that the implied return-stroke speed in the NLDN field-to-current conversion equation is 1.8 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> m/s (the NLDN peak current estimation algorithm is calibrated for negative subsequent strokes). The NLDN uses the same field-to-current conversion procedure (and hence the same implied return-stroke speed) for positive return strokes. However, NLDN-reported peak currents for positive return strokes differ from peak currents predicted by the transmission line model with an assumed return-stroke speed of 1.8 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> m/s. The discrepancy between regression equations for negative and positive return strokes suggests that the NLDN procedure to compensate for field propagation effects and find the average range-normalized signal strength (RNSS) works differently for these two groups of strokes. We find that the difference can be explained by the bias toward NLDN sensor reports from larger distances for positive strokes combined with the higher relative sensor gain (the ratio of sensor's peak current estimate to the NLDN-reported peak current) at larger distances.
Duct resonance and its effect on the performance of high pressure ratio axisymmetric ejectors (1987)

The effect of duct resonance on the performance of high-pressure ratio axisymmetric ejectors was investigated in a series of experiments involving analysis of the emitted noise and schlieren photography of the ejector duct flow. The thrust characteristics obtained with changing blowing pressure were found to contain irregularities, and these were found to be associated with certain tones of acoustic radiation which tuned to the transverse modes of the mixing duct. When varying the blowing pressure for a given ejector the discrete tone fundamental frequency showed a staging behavior, and the frequencies at the discontinuities separating the stages coincided with the calculated modes of the duct. For a given frequency discontinuity, the Helmholtz number (based on duct diameter), was found to be the same for all ejectors tested. For each family of ejectors having the same duct-length to diameter ratio, the blowing pressure at which certain discontinuities occurred varied linearly with duct to nozzle area ratio, and the thrust irregularities assumed similar linear relationships. Increasing the duct length greatly improved thrust augmentation in the relatively high-pressure range and shifted thrust irregularities and the corresponding frequency discontinuities to lower pressure ranges. The schlieren photographs showed that the primary jet spread, and its mixing with the entrained secondary stream, were evidently enhanced by duct resonance. The jet appeared to be surrounded by interspersed helical eddies and to be oscillating in a spinning mode.
Tagging of Model Amphetamines with Sodium 1,2‐Naphthoquinone‐4‐sulfonate: Application to the Indirect Electrochemical Detection of Amphetamines in Oral (Saliva) Fluid (2006)

Abstract Proof‐of‐concept is shown for the indirect electrochemical detection of model amphetamines, D ‐amphetamine sulfate and pseudoephedrine, based on the labeling of the amphetamine models with sodium 1,2‐naphthoquinone‐4‐sulfonate (NQS). The presence of the amphetamine models is monitored via either the reduction in the magnitude of the voltammetric peak corresponding to the electrochemical reduction of the quinone functionality of the sodium 1,2‐naphthoquinone‐4‐sulfonate or via growth of a new voltammetric peak related to reaction between the amphetamine model and NQS, both of which are well resolved from one another. The protocol is shown to be successful in artificial saliva and authentic human oral (saliva) fluid. Such a protocol may be particularly attractive for roadside testing of amphetamines in drug drivers.
Study on Preparation and Characterization of Fish Peptides by Enzymatic Hydrolysis (2007)

In the paper fish protein was hydrolyzed by proteases for preparing fish peptide. The optimum hydrolysis conditions for alcalase are as follows: concentration of fish protein 30%, pH9.0, 50 ℃, ratio of alcalase to fish protein 48 AU/kg, time 120 min. Under these conditions, 76.48%(W/W) of fish peptides with 72.81% purity. Fish peptides with better solubility can be extensively used in the food.
Biochemical and immunologic correlates of clinical response in a combination trial of the GM-CSF-gene transduced allogeneic prostate cancer immunotherapy and ipilimumab in patients with metastatic hormone-refractory prostate cancer (mHRPC) (2007)

5120 Background: A Phase 1 trial is underway to study the GM-CSF-secreting immunotherapy for prostate cancer (GVAX immunotherapy [GVAX IT]) and ipilimumab (ipi) in mHRPC patients (pts). Methods: Twelve pts were treated for 24 weeks (wks) with bi-weekly intradermal injections of GVAX IT and monthly Ipi. Pts were enrolled in cohorts of 3; each cohort received an escalating dose of ipi: 0.3, 1, 3 or 5 mg/kg. Results: Median follow-up is 15.0 months. All pts had GVAX IT injection site reactions. Five of six pts at the higher ipi doses (3 and 5 mg/kg) developed Grade 2 or 3 immune-related endocrinopathy, consistent with hypophysitis manifested by adrenal insufficiency and/or hypothyroidism, all successfully treated with standard hormone replacement. Two pts were tapered off Synthroid within 6 months (m). There was no induction of the alpha-21-hydroxylase auto-antibody that is seen in 90% of cases of auto-immune adrenal insufficiency. One pt in the 5 mg group developed a Grade 3 dose-limiting alveolitis. PSA responses (declines > 50%) were seen in 5/6 treated at the two higher ipi doses with median response duration of 4.9 m (2 on-going at 7.2 m and 12.8 m). These PSA responses were associated with immune-related endocrinopathy but were not consistently correlated with declines in adrenal androgens. One pt had resolution of measurable disease on abdominal CT scan. Immunomonitoring studies showed T cell and dendritic cell activation, more pronounced at higher doses. Biopsies of injection sites showed T cell infiltration. Multiple tumor-reactive antibodies (abs) induced by tx were identified by serologic analysis (SEREX), including abs to filamin B. Screening against 20 defined prostate cancer antigens demonstrated induction of abs to PSMA and NY-ESO-1. Conclusions: The GVAX IT and ipilimumab combination is active in mHRPC. There was an association between PSA response and immune-related adverse events. The PSA responses cannot be accounted for by adrenal insufficiency. The relationship between clinical activity and serologic response to identified antigens is under investigation. Tx of 16 additional pts is planned. No significant financial relationships to disclose.
Pharmacological Differences among Angiotensin II Receptor Antagonists (2001)

Angiotensin II AT1 receptor antagonists (AIIRAs) have demonstrated efficacy similar to other classes of antihypertensive agents as well as "placebo-level" tolerability at all doses. Pharmacokinetic and pharmacodynamic studies provide a framework for understanding important intra-class dissimilarities. Disparity in antagonistic effects may be determined by in vivo responses to challenges of exogenous angiotensin II (Ang II) and by ex vivo/in vitro responses to a drug's biological activity by radioligand receptor assay (RRA). Two independent studies have been conducted in which irbesartan exhibited a more pronounced and longer-lasting antagonism to the effects of exogenous Ang II than losartan and valsartan. Comparative trials have indicated that both irbesartan and candesartan show greater clinical efficacy in lowering blood pressure than losartan. Recently, we have compared the Ang II antagonistic properties of irbesartan 150 mg/day and candesartan 8 mg/day. Both drugs block AT1 receptors with "insurmountable" antagonism and demonstrate a long duration of action. While both irbesartan and candesartan showed a similar degree of antagonistic activity in vivo, distinctly higher antagonistic activity in plasma was found for irbesartan by RRA at all time-points. Furthermore, plasma renin activity during periods with high antagonistic activity was significantly higher, and aldosterone levels following Ang II stimulation were blunted to a greater extent, following administration of irbesartan. In summary, in the doses tested, irbesartan exhibits the strongest antagonism when compared with losartan, valsartan and candesartan. This finding may have clinical implications.
ChemInform Abstract: Uvaricin, a New Antitumor Agent from Uvaria accuminata (Annonaceae). (1983)

Abstract IE5 tumorhemmende Uvaricin besitzt aufgrund spektroskopischer Untersuchungen die Struktur (I).
Synergic Exfoliation of Graphene with Organic Molecules and Inorganic Ions for the Electrochemical Production of Flexible Electrodes (2014)

A facile and efficient method based on electrochemistry for the production of graphene-based materials for electronics is demonstrated. Uncharged acetonitrile molecules are intercalated in graphite by electrochemical treatment, owing to the synergic action of perchlorate ions dissolved in acetonitrile. Then, acetonitrile molecules are decomposed with microwave irradiation, which causes gas production and rapid graphite exfoliation, with an increase in the graphite volume of up to 600 %. Upon further processing and purification, highly dispersible nanosheets are obtained that can be processed into thin layers by roll-to-roll transfer or into thicker electrodes with excellent capacitance stability upon extensive charging/discharging cycles. The good exfoliation yield (>50 % of monolayers), minimal oxidation damage and good electrochemical stability of the nanosheets obtained were confirmed by scanning force and electron microscopy, as well as Raman spectroscopy and galvanostatic analyses.
Thin Films: Past, Present, Future (1995)

Abstract Thin‐film photovoltaics was developed as a means of substantially reducing the cost of photovoltaic (PV) systems. The rationale for this was that thin‐film modules would be cheaper to manufacture owing to their reduced material costs, energy costs, handling costs and capital costs. However, thin films had to he developed using new materials, including amorphous silicon, copper indium diselenide, cadmium telluride and film crystalline silicon. In all cases, these technologies faced major technical and financial hurdles. The most crucial technical barriers are described within the text. Today, much progress has been made and the performance of the best thin‐film laboratory cells approaches the best performance of polycrystalline silicon cells. Outdoor stability has been a problem, especially with amorphous silicon, but this material and newer thin films now display good to excellent stability. It appears that the goal of thin films—truly low‐cost PV electricity that can be sold into energy‐significant markets—can be achieved. However, its achievement will require both the continuing resolution of technical problems and the ongoing investment of significant public and/or private resources.
Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia (2011)

In conclusion, it is suggested that downregulation of Nox-2 and overexpression of MKP-1 that regulate ROS and NO may form the potential therapeutic strategy for the treatment of neuroinflammation in neurodegenerative diseases.
Prediction of Oscillation Frequencies for Unstable Flow Past Cavities (1977)

The incompressible flow of a shear layer past a cavity can undergo relatively large amplitude organized transverse oscillations which arise from hydrodynamic instability. A model which enables prediction of the oscillation frequencies by accounting for streamwise variations in wave number and amplification factor is put forth. Predicted frequencies compare well with experimental data over a tenfold range of dimensionless cavity length.
1.3-$mu$m Four-Channel$,times,$10-Gb/s Parallel Optical Transceiver With Polymer PLC Platforms for Very-Short-Reach Applications (2006)

A four-channel times10-Gb/s parallel optical transceiver for high-capacity very-short-reach applications was developed. The transceiver module was fabricated with low-cost components such as polymer planar lightwave circuit (PLC) platforms and 1.3-mum Fabry-Perot laser diodes (FPLDs). The polymer PLC platform enables the FPLDs or waveguide photodiodes (WGPDs) to be butt-coupled to the polymer waveguide by low-cost passive alignment. Using 1.3-mum FPLDs and single-mode fibers (SMFs) achieves reliable transmission over 600 m. Widening the spacing between the waveguides up to 1 mm suppressed the interchannel crosstalk to below -39 dB. The fabricated transceiver was operated at 10 Gb/s per channel and it successfully demonstrated 600-m error-free transmission. The sensitivity of each channel was better than -14 dBm with an interchannel-crosstalk penalty of less than 0.7 dB
The hysteresis chaos generator family (2003)

Chaos and related phenomena in a simple autonomous circuit family consisting of a resistor, inductor, capacitor, negative resistance, and one hysteresis resistor are investigated. All the circuits in this family are described by an n-dimensional canonical piecewise-linear equation containing one small parameter epsilon . In the case where epsilon is small enough, the analysis is simplified into the hysteretic connecting n-1-dimensional linear system. Therefore, a sufficient condition of chaos generation is rigorously derived for n=3, and an interesting transition from torus to chaos is verified for n=4.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Sulfur Volatiles in Guava (Psidium guajava L.) Leaves: Possible Defense Mechanism (2008)

Volatiles from crushed and intact guava leaves (Psidium guajava L.) were collected using static headspace SPME and determined using GC-PFPD, pulsed flame photometric detection, and GC-MS. Leaf volatiles from four common citrus culitvars were examined similarly to determine the potential component(s) responsible for guava's protective effect against the Asian citrus psyllid (Diaphorina citri Kuwayama), which is the insect vector of Huanglongbing (HLB) or citrus greening disease. Seven sulfur volatiles were detected: hydrogen sulfide, sulfur dioxide, methanethiol, dimethyl sulfide (DMS), dimethyl disulfide (DMDS), methional, and dimethyl trisulfide (DMTS). Identifications were based on matching linear retention index values on ZB-5, DB-Wax, and PLOT columns and MS spectra in the case of DMDS and DMS. DMDS is an insect toxic, defensive volatile produced only by wounded guava but not citrus leaves and, thus, may be the component responsible for the protective effect of guava against the HLB vector. DMDS is formed immediately after crushing, becoming the major headspace volatile within 10 min. Forty-seven additional leaf volatiles were identified from LRI and MS data in the crushed guava leaf headspace.