gebhart/patrepeval huggingface dataset:
Abstract 1898: The combination of gemcitabine/<i>nab</i>-paclitaxel and anti-DLL4 (demcizumab) produces synergistic growth inhibition, delays tumor recurrence and reduces tumor initiating cells in pancreatic cancer (2014)

Abstract Clinical management of pancreatic cancer is challenging and this disease remains the fourth most common cause of cancer-related death. Conventional chemotherapeutic agents, including gemcitabine, commonly used in the treatment of pancreatic cancer, have low response rates and limited effects on improving patient survival. A recent Phase III clinical trial has demonstrated that nab-paclitaxel (Abraxane, a protein-bound paclitaxel) in combination with gemcitabine significantly improved response rate and overall survival compared to patients receiving gemcitabine alone. We previously demonstrated that targeting Notch signaling by anti-DLL4 (demcizumab) inhibits tumor growth, reduces tumor initiating cell frequency and induces differentiation in patient-derived pancreatic xenograft tumors. To further explore the utility of demcizumab in the setting of pancreatic cancer, we evaluated anti-DLL4 combination with gemcitabine/ nab-paclitaxel in a panel of pancreatic xenograft models. We found that anti-DLL4 in combination with gemcitabine plus nab-paclitaxel resulted in striking tumor regression, whereas tumors treated with chemotherapeutic agents alone grew continuously. The effect of the triple combination in some tumors was quite durable and persisted after both antibody and chemotherapeutic treatments were discontinued. The significant growth inhibitory effect by the combination of anti-DLL4 with gemcitabine/nab-paclitaxel was associated with a decrease in cancer stem cell frequency and an increase in apoptosis and tumor cell differentiation. The triple combination of anti-DLL4, gemcitabine and nab-paclitaxel was generally more efficacious compared with anti-DLL4 plus gemcitabine alone. Notably, in a xenograft established from a patient that previously did not respond to demcizumab plus gemcitabine, the triple combination was highly effective. We are currently evaluating demcizumab in combination with gemcitabine plus nab-paclitaxel in a Phase 1b clinical trial in pancreatic cancer. Citation Format: Wan-Ching Yen, Marcus Fischer, John Lewicki, Austin Gurney, Timothy Hoey. The combination of gemcitabine/nab-paclitaxel and anti-DLL4 (demcizumab) produces synergistic growth inhibition, delays tumor recurrence and reduces tumor initiating cells in pancreatic cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1898. doi:10.1158/1538-7445.AM2014-1898
Extraction of Relational structure from time series data using Inductive Logic Programming: A Platform for skillful motion analysis (2009)

今日，スキルの分析が注目されている．スキル分析では協調動作のルール獲得が重要な課題となっており，複数センサーからの時系列データの分析において例えばある系列が状態Ａのあと，しばらくして別の系列で状態Ｂが発生するという関係を扱う必要がある．しかし，現実には時系列データのみで状態が定義されていない入力を扱う状況も多い．こうした中，相関を中心に扱う従来の時系列分析ではデータのもつ時区間を持った特徴同士の関係が扱えないなど複雑な構造の扱いについて不十分な点があった．そこで本論文では，時系列データを状態の遷移系列に変換した上で，帰納的に時区間をもったデータのルールを獲得する手順を提案する．まず，我々は与えられた多変量な計測データのそれぞれの時系列データに対して，局所的に定常なモデルを推定していく．次に，このように推定したものをクラスタリングし，それぞれのクラスタに対して記号を与え，結果として各時系列データを記号の系列データにする．つづいて，得られた系列における記号に開始時点と終了時点を加えて，時区間表現系time-interval-symbol (TIS)に変換する．最後に得られたTISから帰納論理プログラミングを利用し，時区間関係ルールを抽出する．以上の方法を実データに用いた結果，チェロ演奏において有用な知見が得られることが確認できた．
Analysis of the influence of MOS device geometry on predicted SEU cross sections (1999)

An investigation into the single-event sensitive area geometry of a body-tied-to-source (BTS) SOI nMOS transistor has been performed through a novel simulation technique. Results are presented which demonstrate the influence of spatial variations in charge collection efficiency on the shape of the predicted upset cross section curve. Observations are made on a technique for inferring sensitive area or intra-cell collection efficiencies from cross section data.
Time domain method for reduced order network synthesis of large RC circuits (2002)

In this paper we present a time domain method to approximate linear RC multiport networks, accurate up to user specified frequency. We use the Lanczos algorithm to compute eigenvalues, an electrical network based method to compute eigenvectors and use these to synthesize a reduced order RC network. A similar method for RC multiport approximation has been proposed by Yang and Kerns (1996), which works with admittance matrices (G and sC) of the multiport and also uses Lanczos algorithm to compute dominant eigenvalues and eigenvectors. However, their method forbids capacitor cutsets in the multiport, which is a common occurrence in multilayered interconnect modeling, signal integrity analyses etc. We propose an algorithm which works implicitly on the state matrix description of the network and allows capacitor cutsets in the graph of the network. We use an efficient DC analysis algorithm to make implicit computations of eigenvalues, eigenvectors and port admittance matrices.
Estrogen Deficiency Aggravates Insulin Resistance and Induces β-Cell Loss and Diabetes in Female New Zealand Obese Mice (2013)

In several rodent strains such as the New Zealand Obese (NZO) mouse, the incidence of obesity-associated diabetes mellitus is much higher in males than in females. In the present study, we investigated the effects of ovariectomy on glucose homeostasis in female NZO mice in order to elucidate the mechanism of their diabetes resistance. NZO females were ovariectomized at the age of 4 weeks, received a high-fat diet and body weight, body fat, glucose and insulin tolerance were investigated in comparison to sham-operated mice. In a second experiment, operated mice were fed a carbohydrate-free diet up to the age of 19 weeks before they received the high-fat diet. In comparison with a sham-operated control group, ovariectomized female NZO mice exhibited similar body weights, a reduced glucose tolerance, developed significantly higher blood glucose levels, lost insulin producing β-cells, which finally resulted in a diabetes prevalence of 73% at the age of 16 weeks vs. 25% in controls. Similar to male NZO mice, ovariectomized females presented a more severe insulin resistance in the insulin tolerance test than sham-operated controls. Furthermore, the more severe insulin resistance in ovariectomized mice preceded the development of diabetes and pancreatic insulin depletion that was caused by a dietary regimen of carbohydrate restriction and subsequent re-exposure. In summary our data demonstrate that estrogen protects NZO females from β-cell loss and obesity-associated diabetes mellitus. This effect is due to a reduced insulin resistance and possibly also to a reduced sensitivity of β-cells to glucolipotoxic conditions.
Mimotope vaccination for therapy of allergic asthma: anti‐inflammatory effects in a mouse model (2009)

From our data, we conclude that vaccination with a mimotope peptide representing a single IgE epitope of the allergen Phl p 5a and being devoid of allergen-specific T cell epitopes is able to down-regulate inflammation in acute asthma.
Synthesis and Electromagnetic Shielding Property of Pyrolytic Carbon‐Silicon Nitride Ceramics with Dense Silicon Nitride Coating (2011)

Pyrolytic carbon‐silicon nitride ceramics with dense silicon nitride coating ( PyC‐Si 3 N 4 /Si 3 N 4 ) were fabricated by chemical vapor infiltration of PyC into porous Si 3 N 4 ceramics combined with chemical vapor deposition of Si 3 N 4 at their surface. The electromagnetic shielding effectiveness ( SE ) of PyC‐Si 3 N 4 /Si 3 N 4 increases with the increase of PyC content and specimen thickness. When the content of PyC is 11.7 vol% and the thickness of specimen is 2.8 mm, the mean total SE of PyC‐Si 3 N 4 /Si 3 N 4 reaches 43.2 dB in the frequency range of 8.2–12.4 GHz. Due to the excellent sealing effect of dense Si 3 N 4 coating, the mean total SE of PyC‐Si 3 N 4 /Si 3 N 4 remains unchanged even after oxidation at 1100°C for 10 h in air.
Dicoumarol: a unique microtubule stabilizing natural product that is synergistic with Taxol. (2003)

In studies on the antiproliferative actions of coumarin compounds, we discovered that dicoumarol (a coumarin anticoagulant; 3,3'-methylenebis[4-hydroxycoumarin]) inhibits the first cleavage of Strongylocentrotus purpuratus (sea urchin) embryos in a concentration-dependent manner with 50% inhibition occurring at a concentration of 10 microM. Because first cleavage in sea urchin embryos is highly selective for microtubule-targeted agents, we thought that the active compounds might inhibit cell division by interacting with tubulin or microtubules. We found that dicoumarol binds to bovine brain tubulin with a K(d) of 22 microM and that 0.1 microM dicoumarol strongly stabilizes the growing and shortening dynamics at the plus ends of the microtubules in vitro. Dicoumarol reduces the rate and extent of shortening, it increases the percentage of time the microtubules spend in an attenuated (paused) state, and it reduces the overall dynamicity of the microtubules. The antimitotic effects of the widely used cancer chemotherapeutic agent Taxol (paclitaxel) are also mediated by suppressing microtubule dynamics. We demonstrate that exposure to combinations of Taxol and dicoumarol results in a synergistic inhibition of cell division of sea urchin embryos. The results suggest that the antiproliferative mechanism of action of dicoumarol and possibly related pharmacophores may be mediated by tubulin binding and the stabilization of spindle microtubule dynamics. Because of its low toxicity and simple chemical structure, there is potential interest to explore combinations of antimitotic coumarins with other chemotherapeutic agents to improve efficacy and lower toxicity.
Human basophils release interleukin‐4 after stimulation with <i>Schistosoma mansoni</i> egg antigen (1996)

The elevated interleukin (IL)-4 and IgE production in Schistosoma mansoni infection seems to be induced essentially by the egg stage of the parasite. The underlying mechanism, however, is not known. Since basophils from human peripheral blood can produce IL-4, we asked, whether soluble S. mansoni egg antigens (SEA) would trigger basophils to release IL-4. Basophils from healthy human donors (n = 32) without prior history of schistosomiasis were incubated with SEA in the presence of IL-3. In all donors, IL-4 was produced at different concentrations. The IL-4 production was dependent on the dose of SEA, was correlated with the purity of the basophil preparation, and the IL-4 concentration in the culture supernatant was maximal 5 h after stimulation with SEA. In addition to its IL-4-stimulatory effect, SEA triggered basophils to degranulate, thereby releasing histamine and sulfidoleukotrienes. Stripping of receptor-bound IgE from basophils inhibited both SEA- and anti-IgE-induced, but not ionomycin-induced IL-4 production. Moreover, resensitization of stripped basophils with stripping supernatants or human serum restored SEA-induced IL-4 production. This suggests that IgE is involved in the mechanism of IL-4 induction by SEA. Since IL-4 is induced in basophils from nonexposed donors, basophils may play a role as an early source of IL-4 in S. mansoni infection.
6.5% Efficiency of Polymer Solar Cells Based on poly(3‐hexylthiophene) and Indene‐C<sub>60</sub> Bisadduct by Device Optimization (2010)

A power conversion efficiency of 6.48% was achieved for polymer solar cells based on poly(3-hexylthiophene) (P3HT) as donor and indene-C₆₀ bisadduct (ICBA) as acceptor with an open-circuit voltage of 0.84 V, a short-circuit current of 10.61 mA/cm², and a fill factor of 72.7% under irradiation at AM1.5G, 100 mW/cm² at the optimized conditions of P3HT:ICBA = 1:1 (w/w), solvent annealing and pre-thermal annealing at 150 °C for 10 minutes.
Epitaxial metallic β-Nb<sub>2</sub>N films grown by MBE on hexagonal SiC substrates (2015)

RF-plasma MBE was used to epitaxially grow 4- to 100-nm-thick metallic β-Nb2N thin films on hexagonal SiC substrates. When the N/Nb flux ratios are greater than one, the most critical parameter for high-quality β-Nb2N is the substrate temperature. The X-ray characterization of films grown between 775 and 850 °C demonstrates β-Nb2N phase formation. The (0002) and X-ray diffraction measurements of a β-Nb2N film grown at 850 °C reveal a 0.68% lattice mismatch to the 6H-SiC substrate. This suggests that β-Nb2N can be used for high-quality metal/semiconductor heterostructures that cannot be fabricated at present.
Is Metabolic Syndrome Considered to Be a Risk Factor for Gastroesophageal Reflux Disease (Non-Erosive or Erosive Esophagitis)?: A Systematic Review of the Evidence (2016)

It can be concluded that MetS may increase the risk of GERD. Consequently, there might be potential benefits to treating the metabolic abnormalities in these patients.
Structural Effects of Iron Oxide Nanoparticles and Iron Ions on the Hydrothermal Carbonization of Starch and Rice Carbohydrates (2006)

A carbohydrate diet: Free iron ions and Fe2O3 nanoparticles have been employed to direct the hydrothermal carbonization of starch and rice under mild conditions (≤200 °C). Well-defined carbon nanostructures with various forms (see figure) can be conveniently synthesized in gram-scale quantities from these highly abundant starting materials. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2296/2006/z600047_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
An Active Decoupling Capacitance Circuit for Inductive Noise Suppression in Power Supply Networks (2006)

The placement of on-die decoupling capacitors (decap) between the power and ground supply grids has become a common practice in high performance processor designs. In this paper, we present a new active decap circuit that significantly increase the effectiveness of decap in suppressing power supply fluctuations. The proposed circuit senses the supply drop and drives an amplified and inverted voltage fluctuation on the decap. The active decoupling circuit is powered by a separate power supply and we study the optimal allocation of the total C4s/pads between this second power supply and the regular supply as well as the optimal allocation of the total decoupling capacitance between actively switched and traditional static decap. Finally, we demonstrate that the overhead of the proposed method is small compared to the area of the decaps. Using the proposed method, the maximum supply drop is reduced by 45% compared to the use of only traditional decap, corresponding to an increase in the effective decap of approximately 8times.
Hydrogenase Measurement with Photochemically Reduced Methyl Viologen (1969)

Methyl viologen was reduced photochemically in the presence of proflavine and ethylenediaminetetraacetic acid. The reduced methyl viologen was oxidized by hydrogenase from Vibrio succinogenes. H(2) and oxidized methyl viologen were the products. Hydrogenase activity was determined by spectrophotometric measurement of the disappearance of reduced methyl viologen at 600 nm. The extinction coefficient of reduced methyl viologen was determined and is 8.25 mm(-1) x cm(-1) at 600 nm. Optimal conditions for assaying V. succinogenes hydrogenase were developed. Extracts of Escherichia coli and Desulfovibrio desulfuricans catalyzed reduced methyl viologen oxidation in the assay system, whereas Azotobacter vinelandii extracts were inactive.
CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2 (2021)

The ongoing SARS-CoV-2 pandemic necessitates the fast development of vaccines. Recently, viral mutants termed variants of concern (VOC) which may escape host immunity have emerged. The efficacy of spike encoding mRNA vaccines (CVnCoV and CV2CoV) against the ancestral strain and the VOC B.1.351 was tested in a K18-hACE2 transgenic mouse model. Naive mice and mice immunized with a formalin-inactivated SARS-CoV-2 preparation were used as controls. mRNA-immunized mice develop elevated SARS-CoV-2 RBD-specific antibody and neutralization titers which are readily detectable, but significantly reduced against VOC B.1.351. The mRNA vaccines fully protect from disease and mortality caused by either viral strain. SARS-CoV-2 remains undetected in swabs, lung, or brain in these groups. Despite lower neutralizing antibody titers compared to the ancestral strain BavPat1, CVnCoV and CV2CoV show complete disease protection against the novel VOC B.1.351 in our studies.
Velocity variabilities and other physical properties of marine sediments measured by crosswell acoustic tomography (1995)

High-resolution images of the compressional wave velocity structure within various bottom sediments have been determined from high-frequency crosswell acoustic tomography. The three-dimensional wave-number spectra of the velocity variabilities were determined for each measured velocity image. The sediment velocity variability spectra are anisotropic in general. The variability frequency in the vertical direction is much higher than in the horizontal direction. The aspect ratio of the two is found to be approximately 5.0. In addition, the major and minor axes of the anisotropy are often tilted from the vertical and the horizontal direction, respectively. The angle of tilt called dip is found to be as much as 33 deg. The measured velocity power spectra approximate a power law. The spectral strength depends on the sediment type and the location. Based on the rock mechanics transformation procedure by Yamamoto et al. [Geophysics 59, 1530–1541 (1994)], the sediment porosity, density, permeability, and shear strength images have been transformed from the velocity images. These sediment properties, determined from the acoustic crosswell tomography, have been supported by direct measurements on cores and boreholes. The density variabilities of the sediment are found to be similar to the velocity variabilities. Unlike in ocean water, the relative density variabilities in the sediments are much larger than the relative velocity variabilities.
Temperature, Overcharge and Short-Circuit Studies of Batteries used in Electric Vehicles (2017)

Wydawnictwo SIGMA-NOT wydaje czasopisma fachowe informujące swoich czytelników o najnowszych osiągnięciach naukowych i nowoczesnych rozwiązaniach technicznych w Polsce i na świecie, popularyzuje problemy techniczne oraz poszerza wiedzę i kulturę techniczną.
Dimethylarginine Dimethylaminohydrolase Regulates Nitric Oxide Synthesis (2003)

DDAH I overexpression increases NOS activity in vitro and in vivo. The hDDAH-1 transgenic animal exhibits a reduced systolic blood pressure, systemic vascular resistance, and cardiac stroke volume. This study provides compelling evidence that the elaboration and metabolism of endogenous ADMA plays an important role in regulation of NOS activity.
Powder Metallurgy Superalloys (2015)

Abstract Superalloys are predominantly nickel-base alloys that are strengthened by solid-solution elements including molybdenum, tungsten, cobalt, and by precipitation of a Ni3(Al, Ti) type compound designated as gamma prime and/or a metastable Ni3Nb precipitate designated as gamma double prime. This article provides a discussion on the conventional processing, compositions, characteristics, mechanical properties, and applications of powder metallurgy (PM) superalloys. The conventional processing of PM superalloys involves production of spherical prealloyed powder, screening to a suitable maximum particle size, blending the powder to homogenize powder size distribution, loading powder into containers, vacuum outgassing and sealing the containers, and consolidating the powder to full density. PM superalloys include Rene 95, IN-100, LC Astroloy, Udimet 720, N18, ME16, RR1000, Rene 88DT, PA101, MERL 76, AF2-1DA, Inconel 706, AF115, and KM4. The article reviews specialized PM superalloy processes and technical issues in the usage of PM superalloys.
Human Deoxycytidine Kinase (1989)

Deoxycytidine kinase (dC kinase) is the rate-limiting enzyme in the anabolism of important anticancer and retroviral nucleoside derivatives. Its activity is often decreased in resistance to these drugs. To analyze the structure, function, and control of this clinically important enzyme we isolated 15 cDNA clones for human deoxycytidine kinase from lambda gt11 thymus and Molt 4 libraries. Four clones were sequenced. The largest clone is 2.9 kilobases and codes for a 626-amino acid open reading frame. The DNA and deduced amino acid sequence of the human dC kinase clones are homologous with a previously unidentified murine cDNA clone p3.4J (EMBL:MM34j) reported to be related to granulocyte-macrophage colony-stimulating factor. Deoxycytidine kinase also has cysteine-rich regions that are homologous with thioredoxin, the beta subunit of prolyl 4-hydroxylase, phosphoinositide-specific phospholipase C, thyroid hormone-binding protein, and protein disulfide isomerase. No differences were seen in the amount and size of deoxycytidine kinase protein and mRNA between CCRF/CEM and L1210 leukemic cell lines that express and do not express enzyme activity. Genomic restriction fragments were similar between the active and inactive CCRF/CEM cell lines. These data suggest that the cells deficient in dC kinase activity have a small defect in the structural gene.
Intravenous Safety Study in Rats Given Paramagnetic, Polystyrene Beads with Covalently Bound Sheep Anti-Mouse Immunoglobulin G (IgG) (1995)

The potential for acute toxicity from Dynabeads 1 M-450 Sheep Anti-Mouse IgG ST (SAM-Beads) administered once intravenously to male and female rats was assessed. SAM-Beads in saline containing 0.5% plasma protein fraction (PPF) was intravenously administered at dosages of 9.6 times 10 4 or 8.3 times 10 8 beads/kg at a rate of ≥2.5 ml/min/kg. Rats administered 9.6 times 10 4 beads/kg were killed 14 days posttreatment. Rats administered 8.3 times 10 8 beads/kg were killed either 14 or 42 days posttreatment. Saline containing 0.5% PPF served as the control article. Treatment groups were statistically compared with respect to clinical chemistry, hematology parameters, and body weight data. No significant group differences were detected (α = 0.01) with respect to any statistically analyzed data. No SAM-Beads were detected in urine samples collected overnight posttreatment. No test beads were found in any of the tissues from animals administered 9.6 times 10 4 beads/kg. The SAM-Beads were evident in the lung, liver, spleen, lymph nodes, kidney, and sternal bone marrow of rats administered 8.3 times 10 8 beads/kg and killed 14 or 42 days posttreatment. The SAM-Beads observed were recognized as a foreign body and were phagocy-tized by cells of the reticuloendothelial system. The majority of the SAM-Beads were found in the lung, liver, and spleen and were slightly more numerous among animals who were killed at 14 days. There was also a trend toward an increased incidence and/or distribution of phagocytized beads in the bone marrow of animals killed 42 days posttreatment when compared with the 14-day killed animals. A few extracellular beads were present in the lymph nodes, kidneys, and sternal bone marrow. Under the conditions of this study, intravenous administration of Dynabeads M-450 Sheep Anti-Mouse IgG ST did not result in any adverse test-article-related macroscopic, clinical pathologic, or histopathologic changes.