gebhart/patrepeval huggingface dataset:
Data driven hyperparameter optimization of one-class support vector machines for anomaly detection in wireless sensor networks (2017)

One-class support vector machines (OCSVM) have been recently applied to detect anomalies in wireless sensor networks (WSNs). Typically, OCSVM is kernelized by radial bais functions (RBF, or Gausian kernel) whereas selecting Gaussian kernel hyperparameter is based upon availability of anomalies, which is rarely applicable in practice. This article investigates the application of OCSVM to detect anomalies in WSNs with data-driven hyperparameter optimization. Specifically, the information of the farthest and the nearest neighbors of each sample is used to construct the objective cost instead of labeling based metrics such as geometric mean accuracy (G-mean) or area under the receiver operating characteristic (AUROC). The efficiency of this method is illustrated over the IBRL dataset whereas the resulting estimated boundary as well as anomaly detection performance are comparable with existing methods.
[Yawning and sexual excitation under clomipramine. Role of serotoninergic mechanisms. Apropos of 2 cases]. (1992)

We report two cases of a singular side effect induced by clomipramine, one in a man, the other in a woman (both patients were beninese). This consisted of the occurring of the association of very frequent yawning and sexual excitation (sexual excitation with vaginal lubrification for the woman and hypogastric feeling of sexual pleasure for the man). It appeared after a few days of ambulatory treatment of a depression with clomipramine 75 mg/day. Clomipramine and demethylclomipramine blood levels were respectively 85 and 95 ng/ml and 70 and 80 ng/ml for the two patients. Three similar cases had been reported in the literature with this same tricyclic antidepressant. Recently a first case has been reported with fluoxetin. On this basis, it could be suggested that serotoninergic mechanisms are involved in the development of such clinical manifestations. But it seems reasonable to consider that serotoninergic mechanism could interact with a dopaminergic one. In favour of this hypothesis is the implication of dopaminergic mechanisms in yawning in man or in the association yawning--penile erections in the rat. Some others clinical arguments are discussed.
One Step Synthesis of NiO Nanoparticles via Solid-State Thermal Decomposition at Low-Temperature of Novel Aqua(2,9-dimethyl-1,10-phenanthroline)NiCl2 Complex (2013)

[NiCl2(C14H12N2)(H2O)] complex has been synthesized from nickel chloride hexahydrate (NiCl2·6H2O) and 2,9-dimethyl-1,10-phenanthroline (dmphen) as N,N-bidentate ligand. The synthesized complex was characterized by elemental analysis, infrared (IR) spectroscopy, ultraviolet-visible (UV-vis) spectroscopy and differential thermal/thermogravimetric analysis (TG/DTA). The complex was further confirmed by single crystal X-ray diffraction (XRD) as triclinic with space group P-1. The desired complex, subjected to thermal decomposition at low temperature of 400 °C in an open atmosphere, revealed a novel and facile synthesis of pure NiO nanoparticles with uniform spherical particle; the structure of the NiO nanoparticles product was elucidated on the basis of Fourier transform infrared (FT-IR), UV-vis spectroscopy, TG/DTA, XRD, scanning electron microscopy (SEM), energy-dispersive X-ray spectrometry (EDXS) and transmission electron microscopy (TEM).
Variation in the <i>GST mu</i> Locus and Tobacco Smoke Exposure as Determinants of Childhood Lung Function (2009)

Genetic variation across the GST mu locus is associated with 8-year lung function growth. Children of mothers who smoked during pregnancy and had variation in GSTM2 had lower lung function growth.
Principles of electronic instrumentation (1972)

Direct Current Circuits. Capacitors and Inductors. Alternating Current Circuits I. Alternating Current Circuits II. Diodes and Some Applications. Test Equipment and Measurement. Transducers. Transistors. Operational Amplifiers. Waveform Generators. Digital Basics. Digital Circuitry. Microprocessor Basics. Digital and Analog I/O. Noise.
Histophysical demonstration of barium sulphate in acidic epithelia of molluscs and other organisms following irrigation <i>in vivo</i> with aqueous barium chloride (1986)

Journal Article Histophysical demonstration of barium sulphate in acidic epithelia of molluscs and other organisms following irrigation in vivo with aqueous barium chloride Get access T. E. Thompson, T. E. Thompson Search for other works by this author on: Oxford Academic Google Scholar L. J. Gathercole L. J. Gathercole *H.H. Wills, Physics Laboratory, University of BristolTyndall Avenue, Bristol BS8 ITL Search for other works by this author on: Oxford Academic Google Scholar Journal of Molluscan Studies, Volume 52, Issue 3, 13 December 1986, Pages 261–262, https://doi.org/10.1093/mollus/52.3.261 Published: 13 December 1986 Article history Received: 11 March 1986 Published: 13 December 1986
Edge Preserving Smoothing By Multiscale Mode Filtering (2008)

Publication in the conference proceedings of EUSIPCO, Lausanne, Switzerland, 2008
WNT signaling determines tumorigenicity and function of ESC-derived retinal progenitors (2013)

Tumor formation constitutes a major obstacle to the clinical application of embryonic stem cell-derived (ESC-derived) cells. In an attempt to find major extracellular signaling and intrinsic factors controlling tumorigenicity and therapeutic functionality of transplanted ESC-derived retinal progenitor cells (ESC-RPCs), we evaluated multiple kinds of ESC-RPCs in a mouse retinal degeneration model and conducted genome-wide gene expression profiling. We identified canonical WNT signaling as a critical determinant for the tumorigenicity and therapeutic function of ESC-RPCs. The function of WNT signaling is primarily mediated by TCF7, which directly induces expression of Sox2 and Nestin. Inhibition of WNT signaling, overexpression of dominant-negative Tcf7, and silencing Tcf7, Sox2, or Nestin all resulted in drastically reduced tumor formation and substantially improved retinal integration and visual preservation in mice. These results demonstrate that the WNT signaling cascade plays a critical role in modulating the tumorigenicity and functionality of ESC-derived progenitors.
Harvest Indices, Dessert Quality, and Storability of ‘Jonagold’ Apples in Air and Controlled Atmosphere Storage (1988)

Abstract Starch index (SI) was correlated negatively with starch content and positively with internal ethylene concentration (IEC) and logarithm to the base 10 of IEC (loglEC) in ‘Jonagold’ ( Malus domestica Borkh.) apples. The initial rapid increase in SI, loglEC, and yellow ground color coincided with one another and occurred ≈20 days before the increase in IEC and incidence of watercore (WC). In 1984, 1985, and 1986, the first acceptable picking date for British Columbia-grown ‘Jonagold’ was about 10 Oct., when the fruit had attained an acceptable amount of color (50% to 85% area greater than No. 2 red color and 4.0-4.5 yellow color units on a 0-10 scale) and a good level of firmness (73-76 N), soluble solids (13.5% to 14.5%), starch (SI of 6.5-7.0 on a 0-9 scale), and acids (661-782 mg malate/100 ml of juice), but without much WC (2% to 13%) or ethylene (0.3-1.5 μl·liter −1 IEC; 5% to 40% of fruit with IEC > 1 μl·liter −1 ). Fruit picked on 20 Oct. were softer, lower in acids and storage potential, and more susceptible to WC, coreflush (CF), and breakdown (BD) than those picked 10 Oct. Fruit harvested from mature trees stored well at 0°C in air until February and in controlled atmosphere (CA, 1.5% O 2 + 1.5% CO 2 ) until June. Fruit from young trees were large and developed BD in air storage as early as November; fruit afflicted with BD were lower in Ca and higher in K : Ca ratio than those free of the disorder. Dessert and sensory ratings were higher in ‘Jonagold’ than in ‘McIntosh’, ‘Golden Delicious’, ‘Spartan’, and ‘Delicious’ and were also higher in fruit from CA than from air storage.
Computer-assisted simulation of femoroacetabular impingement surgery Concept and preliminary clinical results (2006)

In the past decade, sophisticated computer-assisted meth-ods and simulations have been successfully introduced for various applications and questions in orthopedic surgery [1]. Computerized imaging and visualization tools guaran-
The Stability and Instability of British Society (1999)

The half century since the Second World War can be divided rather crudely into two periods. The first, which lasted until the early 1970s, was one of general confidence, growth and stability. The second was characterized by declining confidence, a bumpy economic record, a sense of declining stability and greater assertiveness by hitherto neglected and silent groups — women, ethnic minorities, gay people and people with disabilities. In the 1980s and 90s, these destabilizing trends became clearer and stronger, for example in rapid and significant changes in families, in increasing crime, in sharpening social division and in the declining availability of work.
Quantum-well infrared photodetector with voltage-switchable quadratic and linear response (2006)

We present a quantum-well infrared photodetector that allows us to switch between a quadratic and a linear detection mode. We employ an asymmetric detector design where intersubband transitions in a three-level system give rise to a quadratic power dependence down to very low excitation densities. Upon reversing the bias voltage, however, the intermediate subband acts as the ejection channel due to highly efficient tunneling, thus leading to a two-level system with linear photoresponse.
Wikipedia edition dynamics (2014)

A model for the probabilistic function followed in Wikipedia edition is presented and compared with simulations and real data. It is argued that the probability to edit is proportional to the editor's number of previous editions (preferential attachment), to the editor's fitness and to an ageing factor. Using these simple ingredients, it is possible to reproduce the results obtained for Wikipedia edition dynamics for a collection of single pages as well as the averaged results. Using a stochastic process framework, a recursive equation was obtained for the average of the number of editions per editor that seems to describe the editing behaviour in Wikipedia.
Migration of multicomponent seismic data using elastic screen method (2001)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2001Migration of multicomponent seismic data using elastic screen methodAuthors: Xiao‐Bi XieRu‐Shan WuXiao‐Bi XieInstitute of Geophysics and Planetary Physics, University of California, Santa Cruz, CA 95064 and Ru‐Shan WuInstitute of Geophysics and Planetary Physics, University of California, Santa Cruz, CA 95064https://doi.org/10.1190/1.1816266 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1816266FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 2001ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2001 Pages: 2135 publication data© 2001 Copyright © 2001 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 03 Jan 2005 CITATION INFORMATION Xiao‐Bi Xie and Ru‐Shan Wu, (2001), "Migration of multicomponent seismic data using elastic screen method," SEG Technical Program Expanded Abstracts : 1069-1072. https://doi.org/10.1190/1.1816266 Plain-Language Summary PDF DownloadLoading ...
Dc-SQUID magnetometers and gradiometers on the basis of quasiplanar ramp-type Josephson junctions (1997)

Nonaqueous Br-ethanol chemical etching was successfully used for the preparation of the Josephson junctions, vias and crossovers in magnetometers including flux transformers. PrBa/sub 2/Cu/sub 3/O/sub 7-x/ thin films were used for the barrier layer in the Josephson junctions of the SQUIDs and as an insulation in the junctions and in the flux transformers. Dc-SQUID magnetometers with small inductances and even without flux antennas were used for NDE applications which mainly require a high dynamic range. Highly sensitive devices were prepared with flip-chip flux antennas. An ac-bias SQUID electronics significantly improves the sensitivity of the magnetometers at low frequencies.
The Spliceosome: A Protein-Directed Metalloribozyme (2017)

Pre-mRNA splicing is executed by the ribonucleoprotein machinery spliceosome. Nearly 40 years after the discovery of pre-mRNA splicing, the atomic structure of the spliceosome has finally come to light. Four distinct conformational states of the yeast spliceosome have been captured at atomic or near-atomic resolutions. Two catalytic metal ions at the active site are specifically coordinated by the U6 small nuclear RNA (snRNA) and catalyze both the branching reaction and the exon ligation. Of the three snRNAs in the fully assembled spliceosome, U5 and U6, along with 30 contiguous nucleotides of U2 at its 5'-end, remain structurally rigid throughout the splicing reaction. The rigidity of these RNA elements is safeguarded by Prp8 and 16 core protein components, which maintain the same overall conformation in all structurally characterized spliceosomes during the splicing reaction. Only the sequences downstream of nucleotide 30 of U2 snRNA are mobile; their movement, directed by the protein components, delivers the intron branch site into the close proximity of the 5'-splice site for the branching reaction. A set of additional structural rearrangement is required for exon ligation, and the lariat junction is moved out of the active site for recruitment of the 3'-splice site and 3'-exon. The spliceosome is proven to be a protein-directed metalloribozyme.
Enhanced Backwards Recursive Path Computation for Multi-area Wavelength Switched Optical Networks Under Wavelength Continuity Constraint (2009)

In the context of the future Internet, all-optical wavelength switched optical networks will play an important role in either evolutionary or revolutionary design paradigms. In any paradigm, dense wavelength domain multiplexing (DWDM) is the most cost-effective technology to increase bandwidth capacity. DWDM provides the basis for a core optical transport infrastructure supporting a wide range of heterogeneous services. However, such all-optical networks raise well-known challenges such as the wavelength continuity constraint (WCC). The WCC is hard to address in a multiarea scenario when provisioning an end-to-end lightpath owing to network topology hiding requirements and the limited exchange of information between areas. The Internet Engineering Task Force (IETF) is currently standardizing the path computation element (PCE) architecture, a good candidate to perform multidomain path computation. In such an architecture, the approach named backwards recursive path computation (BRPC), also under standardization at the IETF, aims at overcoming the limitations of the per-domain mechanism. However, although BRPC does provide end-to-end shortest paths, it fails to take into account the WCC, which is the main motivation for this work. We extend the BRPC algorithm and the companion PCE protocol in order to address the end-to-end WCC efficiently. We perform a quantitative comparative analysis of the different approaches, experimentally showing the improvements of the conceived solution, which has been evaluated in a GMPLS-controlled network of the ADRENALINE testbed.
Molecular basis of mutations at the waxy locus of maize: correlation with the fine structure genetic map. (1985)

More than 40 mutant alleles of the waxy (Wx) locus of maize are available for molecular analysis. Previous studies have examined the nature of phenotypically unstable Wx mutant alleles caused by insertion of the maize transposable activator (Ac) and dissociation (Ds) elements. In this study we have used Southern blot analysis to characterize the locus in 22 strains harboring wx alleles with stable mutant phenotypes. Of these mutations, 17 are of spontaneous origin, 4 were induced by gamma rays, and 1 was induced by ethyl methanesulfonate. Of these 22 alleles, we find that 13 have either insertions or deletions within the Wx transcription unit. The insertions range in size from 150 base pairs to 6.1 kilobases. For 4 of the 6 deletions identified, the two breakpoints are within the Wx gene. For 9 other alleles we can detect no obvious lesions within or around the transcription unit. Evidence is presented that the insertions and deletions result in the mutant phenotype and are not polymorphisms. This conclusion is based on two findings: (i) a survey of inbred lines revealed only a single instance of polymorphism within the transcription unit, whereas all of the lesions described alter the transcription unit; and (ii) there is an excellent correlation between the position of these lesions on the physical map and their relative position on a fine structure genetic map of the locus.
Lane Keeping of Vehicle Using Model Predictive Control (2019)

The MPC approaches, namely, Implicit and Explicit MPC are described in this paper from implementation and analysis points of view for the Lane Keep Assist System of a passenger vehicle in simulated environment. The comparison of the closed loop performance of the said approaches is expected to help the Model in Loop validation of control software development. This could ease and speed up its implementation on the embedded hardware that serves as integral part of LKA feature of Advanced Driver Assistance System. The work uses fundamental equations and develops a simplified model for lateral dynamics of a vehicle as a Linear Parameter Variant state space model in time domain for a commonly followed speed range. The IMPC and EMPC controller actions are computed by constructing and solving optimization problems using Quadratic Programming approach and multi-parametric PWA solver approach respectively with the help of available toolboxes. The tracking performance is simulated for the future lateral deviation from the centre line of driving lane at a chosen look-ahead distance on a road profile of varying curvature. The MPC controllers are further complemented by adopting feed forward control action that may be incorporated by automatic control or by means of steering maneuvers by driver. A qualitative comparison of the two approaches is made along with the comments on trade-offs thereof. It is revealed that both the MPC approaches lead to acceptable performance criteria while IMPC is superior among all. The EMPC facilitates additional benefit of its feasibility to implement on comparatively low end microcontroller and may be considered for cost effective implementations of LKA system.
The intel mote platform: a bluetooth-based sensor network for industrial monitoring (2005)

The Intel mote is a new sensor node platform motivated by several design goals: increased CPU performance, improved radio bandwidth and reliability, and the usage of commercial off-the-shelf components in order to maintain cost-effectiveness. This new platform is built around an integrated wireless microcontroller consisting of an ARM*7 core, a Bluetooth radio, SRAM and FLASH memory, as well as various I/O options. The Intel Mote software architecture is based on an ARM port of TinyOS. Networking and routing layers have been created on top of the TinyOS base to provide Bluetooth-based multi-hop functionality. The network is self-organizing on startup and has mechanisms to repair failed links and circumvent failed nodes. A reliable high bandwidth streaming transport layer has also been created. The Intel Mote was deployed in an equipment monitoring application using industrial vibration sensors. This application was chosen since it benefits from the increased platform capabilities and network bandwidth of the Intel Mote platform. The paper presents a detailed analysis of the observed network operation, packet transfer rates, and power consumption.
Rationalizing the Activities of Diverse Cholecystokinin 2 Receptor Antagonists Using Molecular Field Points (2008)

Cholecystokinin 2 receptor antagonists encompass a wide range of structures. This makes them unsuitable candidates for existing 3D-QSAR methods and has led us to develop an alternative approach to account for their observed biological activities. A diverse set of 21 antagonists was subjected to a novel molecular field-based similarity analysis. The hypothesis is that compounds with similar field patterns will bind at the same target site regardless of their underlying structure. This initial report demonstrates a linear correlation between ligand similarity and biological activity for this challenging data set. A model generated with three molecules was used to predict the activity of 18 test compounds, with different chemotypes, with a root-mean-square error of 0.68 pKB units. The ability to automatically derive a molecular alignment without knowledge of the protein structure represents an improvement over existing pharmacophore methods and makes the method particularly suitable for scaffold-hopping.
Multkilogram Scale-Up of a Reductive Alkylation Route to a Novel PARP Inhibitor (2012)

Novel PARP inhibitor 1 is a promising new candidate for treatment of breast and ovarian cancer. A modified synthetic route to 1 has been developed and demonstrated on 7 kg scale. In order to scale up the synthesis to multikilogram scale, several synthetic challenges needed to be overcome. The key issues included significant thermal hazards present in a Leimgruber–Batcho indole synthesis, a low-yielding side-chain installation, a nonrobust Suzuki coupling and hydrogen cyanide generation during a reductive amination. In addition to these issues, changing from intravenous to oral delivery required a new salt form and therefore a new crystallization procedure. This contribution describes development work to solve these issues and scaling up of the new process in the pilot plant.
Synthesis of phosphatidylethanol--a potential marker for adult males at risk for alcoholism. (1988)

Phosphatidylethanol, whose synthesis is catalyzed by a phospholipase D in a transphosphatidylation reaction, is a unique metabolite of ethanol. Phorbol 12-tetradecanoate 13-acetate, a tumor-promoting phorbol ester and stimulator of protein kinase C, activates this enzyme in peripheral blood lymphocytes. This system has been developed into an assay for measuring the potential of this pathway in human subjects. A pilot study of phosphatidylethanol synthesis in lymphocytes of adult males who have both an alcohol dependency and a family history of alcoholism has revealed that the average potential for phosphatidylethanol synthesis in this population is significantly elevated over that of control subjects.
Microfluidic flow focusing: Drop size and scaling in pressure <b><i>versus</i></b> flow‐rate‐driven pumping (2005)

We experimentally study the production of micrometer-sized droplets using microfluidic technology and a flow-focusing geometry. Two distinct methods of flow control are compared: (i) control of the flow rates of the two phases and (ii) control of the inlet pressures of the two phases. In each type of experiment, the drop size l, velocity U and production frequency f are measured and compared as either functions of the flow-rate ratio or the inlet pressure ratio. The minimum drop size in each experiment is on the order of the flow focusing contraction width a. The variation in drop size as the flow control parameters are varied is significantly different between the flow-rate and inlet pressure controlled experiments.