gebhart/patrepeval huggingface dataset:
A novel link switching scheme using pre-scanning and RSS prediction in visible light communication networks (2013)

Abstract Visible light communication (VLC) is gaining increasing attention and is considered as a promising technology for future wireless indoor communications. Because movable users expect a seamless connectivity experience when switching among transmitters (i.e., VLC access points) in the VLC system, fast link switching operations must be supported by the networks. This paper presents a novel hard link switching scheme for VLC networks with the use of pre-scanning and received signal strength (RSS) prediction. Our proposed scheme achieves the advantages of both conventional hard and soft link switching schemes without changing device hardware or the IEEE 802.15.7 medium access control (MAC) protocol. To help compare our proposed scheme with conventional hard and soft link switching schemes, the signal-to-interference-plus-noise ratio (SINR), the outage probability regarding the link switching situation, and the queuing models for link switching schemes are taken into account. Simulation and numerical results validate that our proposed scheme outperforms conventional hard and soft link switching schemes.
High-efficiency secondary-electron-emission from sputtered MgO-Au cermets (1973)

We have obtained high‐efficiency secondary‐electron emission from a new sputtered cermet system, MgO–Au. Peak yields of 8 and quantum gain for primary‐electron energies as low as 17 eV have been achieved on thick films without the presence of surface charging. The very small insulator particle sizes (< 50 A) in the films permit removal of surface charge by tunneling to adjacent metallic regions. This type of emitter is potentially useful for secondary‐emitting cathodes in high‐power device applications as well as low‐power electron multiplication.
Autologous Bone Marrow Mononuclear Cell Therapy for Severe Traumatic Brain Injury in Children (2010)

Bone marrow harvest and intravenous mononuclear cell infusion as treatment for severe TBI in children is logistically feasible and safe.
Characterizing mutagenic effects of recombination through a sequence-level genetic map (2019)

Genetic diversity arises from recombination and de novo mutation (DNM). Using a combination of microarray genotype and whole-genome sequence data on parent-child pairs, we identified 4,531,535 crossover recombinations and 200,435 DNMs. The resulting genetic map has a resolution of 682 base pairs. Crossovers exhibit a mutagenic effect, with overrepresentation of DNMs within 1 kilobase of crossovers in males and females. In females, a higher mutation rate is observed up to 40 kilobases from crossovers, particularly for complex crossovers, which increase with maternal age. We identified 35 loci associated with the recombination rate or the location of crossovers, demonstrating extensive genetic control of meiotic recombination, and our results highlight genes linked to the formation of the synaptonemal complex as determinants of crossovers.
Surface‐functionalization of plasma‐treated polystyrene by hyperbranched polymers and use in biological applications (2009)

Abstract Nitrogen plasma was used to amino‐functionalize polystyrene surfaces, which were further modified via the selective introduction of polyamines suitable for the immobilization of biological compounds. This chemical modification was carried out using a multifunctional amine compound linked to glutaraldehyde, leading to the formation of hyperbranched structures at the surface. Up to three generations of branched polymers at the polystyrene (PS) surface were created by successive addition of the functional compounds. Amine functions introduced at the surface were labeled with 2,3,4,5,6‐pentafluorobenzaldehyde and analyzed by X‐ray photoelectron spectroscopy (XPS), confirming the successful attachment of each generation of branching. Finally, bovine serum albumin and trypsin were immobilized on N 2 ‐plasma‐treated PS modified with different amounts of branched graft polymer and found to remain bioactive after immobilization. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Lack of detectable defect in DNA double‐strand break repair and DNA‐dependent protein kinase activity in radiosensitive human severe combined immunodeficiency fibroblasts (1996)

The initial step of the V(D)J recombination occurs through the generation of a DNA double-strand break (dsb). Defects in the DNA-dependent protein kinase complex (DNA-PK) result in an inability to perform either V(D)J recombination or any dsb repair effectively. The human autosomal T-B-severe combined immunodeficiency (SCID) condition is characterized by an absence of both B and T lymphocytes and is accompanied in some patients by an increase in gamma-ray sensitivity (T-B-RS SCID) comparable to that found in mouse SCID cells. We show here that cells from six patients with T-B-RS SCID had normal DNA-dsb repair kinetics. Furthermore, DNA-PK activity was present in extracts from these human T-B-RS SCID fibroblasts. We therefore conclude that some human T-B-RS SCID disorders are not caused by a defect in an essential DNA-PK component.
Three-Dimensional Analysis on Stress Patterns within a Sub-salt Formation and an Integrated Method for the Design of a Mud-Weight Window (2013)

Abstract Borehole stability and pore pressure environments downhole transition abruptly, often detrimentally in the presence of salt formations. Geomechanical regimes can vary considerably above, through, and below salts, making accurate modeling of them necessary but challenging. This paper proposes an integrated method that has been developed for predicting the Mud-Weight Window (MWW) of subsalt wells. The high efficiency of the 1D method and high accuracy of the 3Dmethod are deliberately combined in the proposed integrated method, while the disadvantages of those methods are avoided. This objective is achieved by calculating the effective stress ratios, which are part of the input data of the 1D method, with a 3D finite-element (FE) model. The effective stress ratio brings a 3D property into the 1D solution of MWW, thus giving it a 3Dproperty. A 3D model, where the wellbore trajectory was accurately referenced, was built to illustrate and validate the proposed method. A salt body with a thickness of 5.8 km was included. The distribution of the effective stress ratio within the model has been calculated and used in the numerical prediction of the 1D MWW. The prediction of a 3D MWW corresponding to the wellbore trajectory is then derived in the subsalt formation and merged with the numerical prediction.
INVESTIGATION OF METHODS FOR REMOVING STAINS FROM MORTAR AND CONCRETE. (1968)

This investigation consisted of three parts: (a) a literature search to acquire information on the types of stains that can be expected and methods of removal; (b) evaluation of methods of removing stains from mortar specimens; and (c) evaluation of promising stain removal methods on concrete specimens. The literature search indicated that the types of troublesome stains most likely to be found on concrete surfaces are those caused by iron, used lubricating oils, and cutback asphalts. Mortar specimens were made in the laboratory and stained to a mild or severe degree with a solution of iron chloride, lubricating oil, or asphalt. The most effective removal techniques for iron stains were sandblasting, application of an oxalic acid solution, and application of a sodium citrate-sodium hydrosulfite paste. Oil and asphalt stains were not completely removed by any of the methods, but the benzene-CaCO3 paste was the most effective removal method of those used. Concrete specimens were also made, and were severely stained with iron, oil, and asphalt. The most effective removal methods for the iron stains were sandblasting and application of a sodium citrate-sodium hydrosulfite paste; the oil stains were best removed by the sandblasting and the benzene-CaCO3 paste methods. The asphalt stains were not satisfactorily removed by any of the techniques that were tried. (Author)
Tumor Microenvironment–Derived Proteins Dominate the Plasma Proteome Response during Breast Cancer Induction and Progression (2011)

Tumor development relies upon essential contributions from the tumor microenvironment and host immune alterations. These contributions may inform the plasma proteome in a manner that could be exploited for cancer diagnosis and prognosis. In this study, we employed a systems biology approach to characterize the plasma proteome response in the inducible HER2/neu mouse model of breast cancer during tumor induction, progression, and regression. Mass spectrometry data derived from approximately 1.6 million spectra identified protein networks involved in wound healing, microenvironment, and metabolism that coordinately changed during tumor development. The observed alterations developed prior to cancer detection, increased progressively with tumor growth and reverted toward baseline with tumor regression. Gene expression and immunohistochemical analyses suggested that the cancer-associated plasma proteome was derived from transcriptional responses in the noncancerous host tissues as well as the developing tumor. The proteomic signature was distinct from a nonspecific response to inflammation. Overall, the developing tumor simultaneously engaged a number of innate physiologic processes, including wound repair, immune response, coagulation and complement cascades, tissue remodeling, and metabolic homeostasis that were all detectable in plasma. Our findings offer an integrated view of tumor development relevant to plasma-based strategies to detect and diagnose cancer.
The Multidrug Resistance P-glycoprotein (2001)

The human multidrug resistance P-glycoprotein (P-gp), a member of the ATP-binding cassette (ABC) superfamily of transporters, is frequently responsible for the failure of chemotherapy by virtue of its ability to export hydrophobic cytotoxic drugs from cells. Elucidating the inter- and intramolecular interactions of this protein is critical to understanding its cellular function and mechanism of action. Toward this end, we have used both biochemical and genetic techniques to probe potential oligomerization interactions of P-gp. Differentially epitope-tagged P-gp molecules did not co-immunoprecipitate when co-expressed in HEK293 cells or when co-translated in vitro, demonstrating that P-gp is monomeric in both the presence and absence of detergents. The two cytoplasmic domains of P-gp did not interact with each other in vivo when co-expressed as gene fusions in yeast. In contrast, the homologous domains of the transporter associated with antigen processing (TAP), which reside on separate polypeptides and must form a heterodimeric transporter (TAP1/TAP2), did interact in this system, suggesting a role for these domains in TAP dimerization. Implications for understanding the subunit organization of ABC transporters are discussed.
[Approximately hourly biological rhythms: theoretical aspects and the prospects of clinical application]. (2007)

The aim of the review is to attract attention to the importance of a dynamic approach to symptoms of health and pathology. In this regard, long-known approximately 24-hour or circadian rhythms (CR) are very prospective. However, according to recent studies, shorter approximately hourly rhythms (AHR) are of not less importance. Unlike CR, HR are not obtruded on the organism by periodical external influence of day-night pattern, but present cell's own fundamental property, a method of their metabolism. The fractal nature of HR has been substantiated; age-dependent changes in HR have been demonstrated; the importance of AHR for diagnostics and prognosis in gastroenterology and cardiology has been determined. To perform more clinical observations is an important task.
SimLatte: A Framework to Support Testing for Worst-Case Interrupt Latencies in Embedded Software (2014)

Embedded systems tend to be interrupt-driven, yet the presence of interrupts can affect system dependability because there can be delays in servicing interrupts. Such delays can occur when multiple interrupt service routines and interrupts of different priorities compete for resources on a given CPU. For this reason, researchers have sought approaches by which to estimate worst-case interrupt latencies (WCILs) for systems. Most existing approaches, however, are based on static analysis. In this paper, we present SIMLATTE, a testing-based approach for finding WCILs. SIMLATTE uses a genetic algorithm for test case generation that converges on a set of inputs and interrupt arrival points that are likely to expose WCILs. It also uses an opportunistic interrupt invocation approach to invoke interrupts at a variety of feasible locations. Our evaluation of SIMLATTE on several non-trivial embedded systems reveals that it is considerably more effective and efficient than random testing. We also determine that the combination of the genetic algorithm and opportunistic interrupt invocation allows SIMLATTE to perform better than it can when using either one in isolation.
Line Drawings from 3D Models: A Tutorial (2019)

Drawing is the starting point for many kinds of tasks, for everyone from children making pictures to professional architects sketching ideas. Drawing seems to be fundamentally connected to how we represent the world visually. Most computer graphics focuses on realistic visual simulation, but over the past few decades, line drawing algorithms have matured, providing the ability to automatically create reasonable line drawings from 3D geometry. This tutorial provides a detailed guide to the mathematical theory and computer algorithms for line drawing of 3D objects. It focuses on the curves known as contours as they are the most important curves for line drawing of 3D surfaces. The authors describe the different algorithms required to compute and render these curves, before going on to explain boundary curves and surface-surface intersection curves. The tutorial concludes with other topics in 3D non-photorealistic rendering including: other types of curves, stroke rendering, and non-photorealistic shading. Line Drawings from 3D Models: A Tutorial is a concise, yet comprehensive, introduction to an increasingly important topic in computer graphics. The extensive bibliography is invaluable for readers wishing to further their own research in the area.
SYNTHESIS AND AQUEOUS SOLUTION PROPERTIES OF GRAFT COPOLYMERS BASED ON SOY PROTEIN ISOLATE WITH AMINO-TERMINATED POLY(2-ACRYLANMIDO-2-METHYL PROPANE SULFONIC ACID) (2009)

Graft copolymers(SPI-g-NH-PAMPS)were prepared by a graft reaction between the free carboxylic acid groups of soy protein isolate(SPI)and the amino groups of poly(2-acrylanmido-2-methyl propane sulfonic acid)(H_2N-PAMPS)using 1-(3-(dimethylamino)propyl)-3-ethyl-carbodiimide hydrochloride/N-hydroxysuccinimide as the condensing agents in a buffer solution.H_2N-PAMPS and SPI-g-NH-PAMPS were fully characterized by 1H-NMR,FTIR and 13C-NMR spectroscopies.The aqueous solution properties of SPI and SPI-g-NH-PAMPS were studied by zeta potentiometer,UV-Visible spectroscopy,fluorescence spectrometer,dynamic laser light scattering(DLS).The charge of SPI-g-NH-PAMPS measured by zeta potentiometer was negative within the whole pH range studied,which was due to the ionization of sulfonic groups of grafted chains.UV-Visible spectroscopy measurements demonstrated that the solubility of SPI was improved after the graft reaction,especially around the isoelectric point of SPI where it was increased by about 40%,because of the grafted hydrophilic H_2N-PAMPS chains.Fluorescence probing studies with 1-anilinonaphthalene-8-sulfonic acid(ANS)in aqueous solution revealed that the surface hydrophobicity of SPI-g-NH-PAMPS was much weaker than that of SPI.The average hydrodynamic radius(R_h)of SPI aggregates measured by dynamic laser light scattering(DLS)was increased from about 140 nm to about 200 nm.TEM studies indicated that SPI-g-NH-PAMPS aggregates presented a unique core-shell structure because hydrophilic PAMPS long chains surrounded on the surface of SPI globulins,and formed more hydrophilic shell,and the average size of SPI-g-NH-PAMPS aggregates was also bigger than that of SPI aggregates.The graft reaction using EDC provides a new method to modify SPI and expands the application fields of SPI.
SimplE embedding for link prediction in knowledge graphs (2018)

Knowledge graphs contain knowledge about the world and provide a structured representation of this knowledge. Current knowledge graphs contain only a small subset of what is true in the world. Link prediction approaches aim at predicting new links for a knowledge graph given the existing links among the entities. Tensor factorization approaches have proved promising for such link prediction problems. Proposed in 1927, Canonical Polyadic (CP) decomposition is among the first tensor factorization approaches. CP generally performs poorly for link prediction as it learns two independent embedding vectors for each entity, whereas they are really tied. We present a simple enhancement of CP (which we call SimplE) to allow the two embeddings of each entity to be learned dependently. The complexity of SimplE grows linearly with the size of embeddings. The embeddings learned through SimplE are interpretable, and certain types of background knowledge can be incorporated into these embeddings through weight tying. We prove SimplE is fully expressive and derive a bound on the size of its embeddings for full expressivity. We show empirically that, despite its simplicity, SimplE outperforms several state-of-the-art tensor factorization techniques. SimplE's code is available on GitHub at https://github.com/Mehran-k/SimplE.
Verification of a Chemical Reaction Database-Is It Sufficient for Practical Use in Chemical Research? (2003)

本論文では，化学反応データベースの信頼性についての検証結果が述べられている．近年，化学反応データベースを自動的に活用し，化学研究への実践的活用を目指す化学反応予測や合成経路設計の研究が報告されている．これらのコンピュータシステムにとって，その基盤となる化学反応データベースの質と内容は極めて重要である．そこで，データベースの質の基本であり，かつ，検索対象として利用する場合にも重要であることから，データの信頼性についての検証が行なわれている．６０万件の化学反応データから抽出した３２９件の反応データのうち１５１件に誤データが見つけられている．誤データの事例と現行の一般的な反応データベースの抱える課題について考察が行なわれる．
Transfer Hydrogenation with Ruthenium Complexes of Chiral (Phosphinoferrocenyl)oxazolines (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTransfer Hydrogenation with Ruthenium Complexes of Chiral (Phosphinoferrocenyl)oxazolinesTarek Sammakia and Eric L. StangelandView Author Information Department of Chemistry and Biochemistry, University of Colorado Boulder, Colorado 80309-0215Cite this: J. Org. Chem. 1997, 62, 18, 6104–6105Publication Date (Web):September 5, 1997Publication History Received18 June 1997Published online5 September 1997Published inissue 1 September 1997https://doi.org/10.1021/jo9711044Copyright © 1997 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1121Altmetric-Citations106LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (129 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Catalysts,Ketones,Ligands,Transfer reactions Get e-Alerts
Glycolytic enzyme inhibitors in cancer treatment (2008)

Several glycolytic inhibitors are currently in preclinical and clinical development. Their clinical value as anticancer agents, above all in terms of therapeutic index, strictly depends on a careful reevaluation of the pathophyiological role of the unique metabolism of cancer cells in general and of Warburg effect in particular.
Impact of<i>gyrA</i>and<i>parC</i>Mutations on Quinolone Resistance, Doubling Time, and Supercoiling Degree of<i>Escherichia coli</i> (1999)

Isogenic mutants derived from quinolone-susceptible isolate WT by introducing gyrA (S83L, D87G) and parC (S80I, E84K) mutations associated with quinolone resistance were characterized with respect to quinolone resistance, growth rate, and degree of global supercoiling. The latter was determined by use of a pair of reporter plasmids carrying supercoiling-dependent promoters pgyrA and ptopA, respectively, transcriptionally fused to the reporter gene bla coding for TEM-1 beta-lactamase. The quotient (Qsc) of the beta-lactamase specific activity determined for a mutant carrying either plasmid was taken as a measure of the degree of global supercoiling. These Qsc data were comparable to results obtained from the separation of topoisomers of plasmid pBR322 on chloroquine-containing agarose gels and indicate a reduced degree of negative supercoiling in resistant mutants relative to the parent, WT. The S83L mutation in gyrA had the strongest influence on quinolone resistance while leaving other parameters nearly unaffected. The gyrA double mutation (S83L plus D87G) had an effect on quinolone resistance similar to that of a single mutation. Phenotypic expression of the parC mutation (S80I) was dependent on the presence of at least one gyrA mutation. Expression of high-level fluoroquinolone resistance (ciprofloxacin MIC, > 4 micrograms/ml) required a combination of the gyrA double mutation and one parC mutation (S80I or E84K). Such mutants showed considerable alterations of growth rate, global supercoiling, or both. Introduction of a parC mutation affected neither the doubling time nor the degree of supercoiling, while the presence of the gyrA D87G mutation was associated with a significant reduction in the degree of DNA supercoiling.
Docetaxel Combined With Trastuzumab Is an Active Regimen in HER-2 3+ Overexpressing and Fluorescent In Situ Hybridization–Positive Metastatic Breast Cancer: A Multi-Institutional Phase II Trial (2004)

Trastuzumab plus docetaxel is an active and well-tolerated regimen in women with HER-2 3+ overexpressing or FISH-positive metastatic breast cancer.
Ion-Specific Effects under Confinement: The Role of Interfacial Water (2010)

All-atom molecular dynamics simulations were employed for the study of the structure and dynamics of aqueous electrolyte solutions within slit-shaped silica nanopores with a width of 10.67 A at ambient temperature. All simulations were conducted for 250 ns to capture the dynamics of ion adsorption and to obtain the equilibrium distribution of multiple ionic species (Na+, Cs+, and Cl(-)) within the pores. The results clearly support the existence of ion-specific effects under confinement, which can be explained by the properties of interfacial water. Cl(-) strongly adsorbs onto the silica surface. Although neither Na+ nor Cs+ is in contact with the solid surface, they show ion-specific behavior. The differences between the density distributions of cations within the pore are primarily due to size effects through their interaction with confined water molecules. The majority of Na+ ions appear within one water layer in close proximity to the silica surface, whereas Cs+ is excluded from well-defined water layers. As a consequence of this preferential distribution, we observe enhanced in-plane mobility for Cs+ ions, found near the center of the pore, compared to that for Na+ ions, closer to the solid substrate. These observations illustrate the key role of interfacial water in determining ion-specific effects under confinement and have practical importance in several fields, from geology to biology.