gebhart/patrepeval huggingface dataset:
Inhibition of Cellular Proliferation through IκB Kinase-Independent and Peroxisome Proliferator-Activated Receptor γ-Dependent Repression of Cyclin D1 (2001)

The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-regulated nuclear receptor superfamily member. Liganded PPARgamma exerts diverse biological effects, promoting adipocyte differentiation, inhibiting tumor cellular proliferation, and regulating monocyte/macrophage and anti-inflammatory activities in vitro. In vivo studies with PPARgamma ligands showed enhancement of tumor growth, raising the possibility that reduced immune function and tumor surveillance may outweigh the direct inhibitory effects of PPARgamma ligands on cellular proliferation. Recent findings that PPARgamma ligands convey PPARgamma-independent activities through IkappaB kinase (IKK) raises important questions about the specific mechanisms through which PPARgamma ligands inhibit cellular proliferation. We investigated the mechanisms regulating the antiproliferative effect of PPARgamma. Herein PPARgamma, liganded by either natural (15d-PGJ(2) and PGD(2)) or synthetic ligands (BRL49653 and troglitazone), selectively inhibited expression of the cyclin D1 gene. The inhibition of S-phase entry and activity of the cyclin D1-dependent serine-threonine kinase (Cdk) by 15d-PGJ(2) was not observed in PPARgamma-deficient cells. Cyclin D1 overexpression reversed the S-phase inhibition by 15d-PGJ(2). Cyclin D1 repression was independent of IKK, as prostaglandins (PGs) which bound PPARgamma but lacked the IKK interactive cyclopentone ring carbonyl group repressed cyclin D1. Cyclin D1 repression by PPARgamma involved competition for limiting abundance of p300, directed through a c-Fos binding site of the cyclin D1 promoter. 15d-PGJ(2) enhanced recruitment of p300 to PPARgamma but reduced binding to c-Fos. The identification of distinct pathways through which eicosanoids regulate anti-inflammatory and antiproliferative effects may improve the utility of COX2 inhibitors.
Designing self-exercising analogue checkers (2002)

The design of checkers suitable for concurrent error detection in analogue and mixed-signal circuits is addressed in this paper. These checkers can on-line test duplicated and fully differential analogue functional circuits and comply with existing digital self-checking parts. A test pattern generator for off-line testing of the checkers is proposed, which fully exercises their capability of signalling functional error occurrences.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Just because it (1998)

Anyone can publish an Internet Draft. This doesn't mean that the
IETF thinks or that the IETF is planning... or anything similar.
Automatic sensor placement from vision task requirements (1988)

The problem of automatically generating the possible camera locations for observing an object is defined, and an approach to its solution is presented. The approach, which uses models of the object and the camera, is based on meeting the requirements that: the spatial resolution be above a minimum value, all surface points be in focus, all surfaces lie within the sensor field of view and no surface points be occluded. The approach converts each sensing requirement into a geometric constraint on the sensor location, from which the three-dimensional region of viewpoints that satisfies that constraint is computed. The intersection of these regions is the space where a sensor may be located. The extension of this approach to laser-scanner range sensors is also described. Examples illustrate the resolution, focus, and field-of-view constraints for two vision tasks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Control of Saltcedar by Subsurface Placement of Herbicides (1979)

A root plow modified for deep subsurface placement of herbicides effectively controlled saltcedar (Tamarix ramosissima Ledeb.). One operation, preferably in the spring, which severed the tap root 35 to 60 cm below the soil surface and simultaneously applied any of several herbicides at the same depth increased saltcedar kill by more than 100% over that of root cutting alone. Residual herbicides, including uracils, substituted ureas, 2,3,6-TBA, picloram, dicamba, and karbutilate, applied with the root plow consistently controlled saltcedar with a single treatment. Phenoxy herbicides showed initial activity against saltcedar but did not persist long enough to satisfactorily kill late sprouting, previously quiescent buds. Two arsenicals and dichlobenil were ineffective for saltcedar control.
Phase I and Pharmacokinetic Study of the Oral Farnesyltransferase Inhibitor Lonafarnib Administered Twice Daily to Pediatric Patients With Advanced Central Nervous System Tumors Using a Modified Continuous Reassessment Method: A Pediatric Brain Tumor Consortium Study (2007)

Although the estimated MTD by the CRM model was 98.5 mg/m2/dose, because of the relatively constant observed DLT rate at the lower four dose levels, the recommended phase II dose of lonafarnib is 115 mg/m2/dose administered twice daily by mouth with concurrent loperamide.
Design, Synthesis, and Biological Evaluation of the N‐Diarylalkenyl‐piperidinecarboxylic Acid Derivatives as GABA Uptake Inhibitors (I). (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cholesterol Lowering Effect of Metformin in Combined Hyperlipidemia: Placebo Controlled Double Blind Trial (1990)

Metformin, an antidiabetic biguanide derivative, prevents experimental atherosclerosis and induces structural changes in lipoproteins in experimental animals. In the present study we investigated the effect of metformin on serum lipoproteins and platelet function in 24 non-diabetic patients with type II B hyperlipidemia. The patients were randomly given metformin in two dosage levels (1.0 g/day and 2.0 g/day) and placebo for periods of nine weeks in a crossover trial. Metformin caused a dose dependent fall in the concentrations of total serum cholesterol and of LDL-cholesterol. The average concentration of total cholesterol was 8.54 +/- 0.22 (SE) mmol/l, 8.12 +/- 0.19 mmol/l and 7.79 +/- 0.15 mmol/l during placebo, metformin 1.0 g/day and 2.0 g/day treatments, respectively. Both metformin values differed significantly (P less than 0.05) from the placebo value. Thus there was an average fall of 8.1% in total cholesterol after the higher metformin dose. LDL-cholesterol was 5.25 +/- 0.23 mmol/l after placebo, falling by 3.1% and 9.6% after metformin doses of 1.0 g/day and 2.0 g/day, respectively. The concentrations of HDL-cholesterol and total serum triglycerides showed no significant changes. Body weight, blood glucose, plasma insulin, blood lactate, platelet function and urinary excretion of prostanoids remained unchanged during the study. The reduction of total- and LDL-cholesterol levels may be a welcome additional consequence of metformin during treatment of diabetic patients with hypercholesterolemia.
An NMR study of the alkali metal intercalation phase Li<i>x</i>TiS2: Relation to structure, thermodynamics, and ionicity (1976)

The Knight shift and electric quadrupole coupling constant have been measured as a function of lithium concentration in the continuous intercalation phase LixTiS2 where 0⩽x⩽1. These NMR data, when compared with observations of c axis dilation and thermodynamics of this phase, suggest the donation of an appreciable fraction of the Li 2s electron to the TiS2 layers during intercalation, with the fraction diminishing as x increases. The relation of the charge donated to each of the observed quantities is discussed.
Three-Dimensional Assemblies of Gold Colloids in Nanoporous Alumina Membranesast; (1998)

Examples of a new class of three-dimensionally arranged gold colloids have been prepared in the nanoscale pores of alumina membranes. Immobilization of the colloid particles was achieved by a modification of the inner walls with alkoxysilanes Y–(CH2)x–Si(OR)3 and Y–(CH2)x–SiR(OR)2 bearing suitable functional groups (Y = NH2, SH), followed by anchoring of the colloids by self-assembly onto the modified surface. This procedure gives tight and stable ensembles of colloids on the walls. TEM analyses revealed uniform and random colloidal dispersions on the walls in the form of sub-monolayers without any aggregation. UV/Vis spectra of the filled membranes showed an absorption maximum at ca. 525 nm arising from an excitation of the plasmon resonance of the gold colloids. The dimensions of the pores can be “tuned” and given the diverse range of different colloids available, routes to novel catalysts and sensors can be envisaged.
Regulation of X-Chromosome Counting by <i>Tsix</i> and <i>Xite</i> Sequences (2005)

In mammals, X-inactivation establishes X-chromosome dosage parity between males and females. How X-chromosome counting regulates this process remains elusive, because neither the hypothesized inactivation "blocking factor" nor the required cis-elements have been defined. Here, a mouse knockout and transgenic analysis identified DNA sequences within the noncoding Tsix and Xite genes as numerators. Homozygous deficiency of Tsix resulted in "chaotic choice" and a variable number of inactive X's, whereas overdosage of Tsix/Xite inhibited X-inactivation. Thus, counting was affected by specific Tsix/Xite mutations, suggesting that counting is genetically separable from but molecularly coupled to choice. The mutations affect XX and XY cells differently, demonstrating that counting and choice are regulated not by one "blocking factor," but by both a "blocking" and a "competence" factor.
Telomerase activity and oncogenesis in giant cell tumor of bone (1995)

Telomere reduction and telomerase activity may be oncogenic sustaining events required to maintain the transformed phenotype seen in GCT.
Industrial pollution prevention handbook (1996)

Pollution Prevention: A New Agenda Overview of Pollution Prevention.Laws, Regulations and Government Incentives: P2 Elements in U.S.Environmental Laws.Expanding Pollution Prevention Framework: Roles for State and Local Governments.Voluntary Programs.State Facility Planning Requirements.Incentives and Barriers.Industrial P2 Programs: Designing and Implementation: Designing and Maintaining a P2 Program.P2 and Total Quality Management.Examples of Successful P2 Programs.Agile Manufacturing.P2 Implementation Techniques: Facility Prevention Planning.Descriptive Approach for P2 Assessment.Application of Risk Analysis for Setting Priorities.The Bottom Line: Profitability Analysis of P2 Investments Using Total Cost Analysis.Accounting Principles for P2.Measuring P2 Progress.Product Design for P2: P2 Principles of Design.Life Cycle Assessment.Product Labeling.Process Design for P2: Process Development and Synthesis.Reaction Engineering.Separation Technologies.Pollution Prevention Through Process Control.Process Simulation.P2 Through Chemistry.Mixing as a Pollution Prevention Tool.Generic Pollution Prevention: Process Equipment for Cleaning and Degreasing.P2 in Coating Application and Removal.P2 in Office Operations.P2 in Laboratory Operations.Solvent Substitutes.Maintenance Operations and Pollution Prevention.Quantitative Methods of Determining Cleanliness.Materials Management.Water Management Techniques for Pollution Prevention.Industry Specific Techniques: An Overview of Potential Environmental Impact from Industrial Activity.Biotechnology and P2: Industry and Opportunity.P2 in the Electronics Industry.Industrial Waste Recycling at an Automotive Component Manufacturing.Foundries.P2 in the Power Generation Industry.Metals Fabrication.P2 in the Chemical Industry.P2 in the Petroleum Refining Industry.P2 in Electroplating Industries.P2 Automotive Manufacturing.Wood Furniture Finishing.Encouraging P2 Through Publicly Owned Treatment Works.P2 in the Textiles Insdustry.P2 in the Pulp and Paper Industry.Pharmaceuticals.P2 Organizations and Information Resources Sources.
One seed to find them all (2012)

Feature-based opinion analysis has attracted extensive attention recently. Identifying features associated with opinions expressed in reviews is essential for fine-grained opinion mining. One approach is to exploit the dependency relations that occur naturally between features and opinion words, and among features (or opinion words) themselves. In this paper, we propose a generalized approach to opinion feature extraction by incorporating robust statistical association analysis in a bootstrapping framework. The new approach starts with a small set of feature seeds, on which it iteratively enlarges by mining feature-opinion, feature-feature, and opinion-opinion dependency relations. Two association model types, namely likelihood ratio tests (LRT) and latent semantic analysis (LSA), are proposed for computing the pair-wise associations between terms (features or opinions). We accordingly propose two robust bootstrapping approaches, LRTBOOT and LSABOOT, both of which need just a handful of initial feature seeds to bootstrap opinion feature extraction. We benchmarked LRTBOOT and LSABOOT against existing approaches on a large number of real-life reviews crawled from the cellphone and hotel domains. Experimental results using varying number of feature seeds show that the proposed association-based bootstrapping approach significantly outperforms the competitors. In fact, one seed feature is all that is needed for LRTBOOT to significantly outperform the other methods. This seed feature can simply be the domain feature, e.g., "cellphone" or "hotel". The consequence of our discovery is far reaching: starting with just one feature seed, typically just the domain concept word, LRTBOOT can automatically extract a large set of high-quality opinion features from the corpus without any supervision or labeled features. This means that the automatic creation of a set of domain features is no longer a pipe dream!
Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA (2008)

DNA polymerases are co-ordinated by sliding clamps (PCNA/beta-clamp) in translesion synthesis. It is unclear how these enzymes assemble on PCNA with geometric and functional compatibility. We report the crystal structure of a full-length Y-family polymerase, Dpo4, in complex with heterodimeric PCNA1-PCNA2 at 2.05 A resolution. Dpo4 exhibits an extended conformation that differs from the Dpo4 structures in apo- or DNA-bound form. Two hinges have been identified in Dpo4, which render the multidomain polymerase flexible conformations and orientations relative to PCNA. Dpo4 binds specifically to PCNA1 on the conserved ligand binding site. The C-terminal peptide of Dpo4 becomes structured with a 3(10) helix and dominates the specific binding. The Y-family polymerase also contacts PCNA1 with its finger, thumb and little finger domains, which are conformation-dependent protein-protein interactions that diversify the binding mode of Dpo4 on PCNA. The structure reveals a molecular model in which substrate/partner binding-coupled multiple conformations of a Y-family polymerase facilitate its recruitment and co-ordination on the sliding clamp. The conformational flexibility would turn the error-prone Y-family polymerase off when more efficient high-fidelity DNA polymerases work on undamaged DNA and turn it onto DNA templates to perform translesion synthesis when replication forks are stalled by DNA lesions.
Attenuated measles virus used as an oncolytic virus activates myeloid and plasmacytoid dendritic cells (2013)

Attenuated measles viruses (MV) are assessed in clinical trials for their capacity to preferentially infect and kill tumor cells. We recently showed that MV-infected tumor cells are able to activate tumor antigen cross-presentation by myeloid and plasmacytoid dendritic cells. Thus, MV-based antitumor virotherapy may stimulate antitumor immune response.
Trends in the rapid diagnosis of viral infections. (1983)

The authors discuss different aspects of the rapid diagnosis of viral infections: its necessity, its characteristics, the recent advances having allowed the development of modern techniques. Further, the main categories of procedures used in rapid viral diagnosis are reviewed: 1) electron microscopy, 2) immunofluorescence and immunoperoxidase techniques; 3) solid-phase systems with labelled reactants; 4) agglutination with supporting particles; 5) counterimmunoelectrophoresis; 6) rapid/early serological diagnosis. Data are discussed as regards the possibility of the large-scale application of rapid viral diagnosis procedures in Romania.
A Study of Polymer Electrolyte Fuel Cells by the Measurement of AC Impedance, Current Interrupt, and Dew Points: 2. Effect of Cell Temperature (2002)

The effect of cell temperature on the performance of a polymer electrolyte fuel cell was examined in the present study. Measurements using the current interrupt and AC impedance methods showed that membrane resistance increased as the cell temperature was reduced. The charge transfer resistance, determined by the AC impedance method, also increased with decreasing cell temperature. The results of electrochemical analysis showed that the temperature of the cell strongly affected the performance of the membrane–electrode assembly in the cell. In addition, the water balance calculated from dew points of fuel gases changed with cell temperature. At a cell temperature of 80 °C, ca. 80% of the water generated on the cathode passed through the membrane to the anode, while at a cell temperature of 40 °C, only ca. 20% of the water on the cathode passed through the membrane to the anode.
Eco-exergy and emergy based self-organization of three forest plantations in lower subtropical China (2015)

The bio-thermodynamic structures of a mixed native species plantation, a conifer plantation and an Acacia mangium plantation in Southern China were quantified over a period of 15 years based on eco-exergy methods. The efficiencies of structural development and maintenance were quantified through an integrated application of eco-exergy and emergy methods. The results showed that the storage of eco-exergy increased over 3 times in all three plantations, as predicted by the maximum eco-exergy principle. This trend was primarily seen due to the accumulation of biomass, instead of an increase in the specific eco-exergy (eco-exergy per unit biomass), although species richness did increase. The eco-exergy to emergy and eco-exergy to empower ratios of the three plantations generally increased during the study period, but the rate of increase slowed down after 20 years. The dominant trees are the largest contributors to the eco-exergy stored in the plantations, and thus, the introduction of suitable indigenous tree species should be considered after the existing trees pass through their period of most rapid growth or around 20 years after planting. The combined application of C-values and suggested weighting factors in the eco-exergy calculation can imply opposite results, but may also supply useful information for forest management.
Applications of Mixed Reality in Process Safety and Operational Integrity (2018)

Abstract In proposing a modern approach to process industry operational integrity management, a question that often surfaces is "What is the most complex activity within operational integrity management that affects performance, productivity and efficiency?". There are variety of answers to this question, one answer being "Human limitations in conceiving data to make informed decisions". The objective of this presentation is to outlines the key benefits of mixed reality platforms in presenting data to managers, operators and maintenance personnel working in an Oil & Gas facility. Process industry in the past did not generate as much data as it does today. With the amount of data generated every day, it is necessary to innovate so as to analyze data and visually represent them thereby providing a "total immersive knowledge". In light of the recent developments in mixed reality platforms, it is now possible to use this technology to visually present data focused around the needs of humans. Using mixed reality, one can merge the view of real equipment of a plant with a virtual world of data, simulation and instructions, such that both the physical and digital world co-exist. Few of the applications of this technology in the Oil & Gas industry are 1) providing safe operations, maintenance and repair instructions real time 2) monitor, record and analyze data real time during inspections 3) visualize data outside the control room 4) effectively train personnel during visits 5) analyze trends and predict outcomes 6) share data with managers, vendors for efficient decisions. The presentation outlines the key benefits of mixed reality platforms such as Microsoft Hololens in presenting data to managers, operators and maintenance personnel working in an Oil & Gas facility. The presentation will also discuss findings of a sponsored pilot project where mixed reality was implemented. At the end, the presentation will also raise the current challenges and possible solutions in successfully implementing such technologies.
Rates of hydrogen chloride oxidation (1966)

Abstract Rates of oxidation of hydrogen chloride (the Deacon process) were measured in a recycling reactor with chromic oxide catalysts. The temperatures were 325° to 355°C., and a wide range of reactant compositions was used. The reverse reaction was also explored at 355° to 370°C. The experimentation was carefully tested to be sure that the construction material did not affect the results and that diffusional effects were absent. An empirical equation is described which correlates well the rates of oxidation and fits the original observed data. It is capable of predicting reasonably well some of the observed rates of the reverse reaction.
Development of a Method to Produce High Energy Blasting Prills (1976)

A method has been developed for the production of high energy blasting prills (HEBP) containing TNT/Al or TNT/RDX/Al; the average particle size of the prills is approximately 3 mm. Such HEBP explosives seem attractive for special military engineering applications because they are free-flowing, water resistant, have a long shelf life and can be used over a wide temperature range. The method consists of forming fluid droplets of a molten mixture of explosive at the tip of a small-diameter nozzle immersed in the top of a water column. After the droplets leave the nozzle, they solidify as they fall through the remainder of the column. To avoid building up static charges, the prills are made semi-conductive by coating them with a thin layer of graphite. Studies were first undertaken in the laboratory and then scaled up to a 44-cm diameter pilot-plant prilling column that can produce about 90 kg of prills per batch. Some 1000 kg of each of two different compositions were produced for determination of their cratering characteristics (in a separate study). (Author)