gebhart/patrepeval huggingface dataset:
Mining top-n local outliers in large databases (2001)

Outlier detection is an important task in data mining with numerous applications, including credit card fraud detection, video surveillance, etc. A recent work on outlier detection has introduced a novel notion of local outlier in which the degree to which an object is outlying is dependent on the density of its local neighborhood, and each object can be assigned a Local Outlier Factor (LOF) which represents the likelihood of that object being an outlier. Although the concept of local outliers is a useful one, the computation of LOF values for every data objects requires a large number of κ-nearest neighbors searches and can be computationally expensive. Since most objects are usually not outliers, it is useful to provide users with the option of finding only n most outstanding local outliers, i.e., the top-n data objects which are most likely to be local outliers according to their LOFs. However, if the pruning is not done carefully, finding top-n outliers could result in the same amount of computation as finding LOF for all objects. In this paper, we propose a novel method to efficiently find the top-n local outliers in large databases. The concept of "micro-cluster" is introduced to compress the data. An efficient micro-cluster-based local outlier mining algorithm is designed based on this concept. As our algorithm can be adversely affected by the overlapping in the micro-clusters, we proposed a meaningful cut-plane solution for overlapping data. The formal analysis and experiments show that this method can achieve good performance in finding the most outstanding local outliers.
A study of 13CH coupling constants in hexopyranoses (1974)

Proton decoupled and undecoupled 13C n.m.r. spectra have been measured on a number of hexopyranoses. The direct coupling constants between the anomeric carbon atoms and protons {1J[13C–H(1)]} were found to be ca. 160 in the β-anomers and ca. 170 Hz in the α-anomers; the difference of ca. 10 Hz between pairs of anomers was found in almost all cases. Chemical shifts and 1J(13CH) values of the other carbon atoms in the pyranose rings were also measured.
Computational alanine scanning of the 1:1 human growth hormone–receptor complex (2001)

The MM-PBSA (Molecular Mechanics-Poisson-Boltzmann surface area) method was applied to the human Growth Hormone (hGH) complexed with its receptor to assess both the validity and the limitations of the computational alanine scanning approach. A 400-ps dynamical trajectory of the fully solvated complex was simulated at 300 K in a 101 A x 81 A x 107 A water box using periodic boundary conditions. Long-range electrostatic interactions were treated with the particle mesh Ewald (PME) summation method. Equally spaced snapshots along the trajectory were chosen to compute the binding free energy using a continuum solvation model to calculate the electrostatic desolvation free energy and a solvent-accessible surface area approach to treat the nonpolar solvation free energy. Computational alanine scanning was performed on the same set of snapshots by mutating the residues in the structural epitope of the hormone and the receptor to alanine and recomputing the deltaGbinding. To further investigate a particular structure, a 200-ps dynamical trajectory of an R43A hormone-receptor complex was simulated. By postprocessing a single trajectory of the wild-type complex, the average unsigned error of our calculated deltadeltaGbinding is approximately1 kcal/mol for the alanine mutations of hydrophobic residues and polar/charged residues without buried salt bridges. When residues involved in buried salt bridges are mutated to alanine, it is demonstrated that a separate trajectory of the alanine mutant complex can lead to reasonable agreement with experimental results. Our approach can be extended to rapid screening of a variety of possible modifications to binding sites.
The Narrative Impact of Active Video Games on Physical Activity Among Children: A Feasibility Study (2016)

Background: Active video games (AVGs) capable of inducing physical activity offer an innovative approach to combating childhood obesity. Unfortunately, children’s AVG game play decreases quickly, underscoring the need to identify novel methods for player engagement. Narratives have been demonstrated to influence behaviors. Objective: The objective of this study was to test the hypothesis that a narrative would motivate increased AVG play, though a feasibility study that investigated the motivational effect of adding a previously developed narrative cutscene to an originally nonnarrative AVG, Nintendo Wii Sports Resort: Swordplay Showdown. Methods: A total of 40 overweight and obese 8- to 11-year-olds equally divided by sex played the AVG. Half (n=20) were randomly assigned to a narrative group that watched the narrative cutscene before game play. The other half played the game without watching it. Results: Children in the narrative group had significantly (P<.05) more steps per 10-second period (mean 3.2, SD 0.7) and overall (mean 523, SD 203) during game play compared with the nonnarrative group (10-second period: mean 2.7, SD 0.7; overall: mean 366, SD 172). Conclusions: The AVG with narrative induced increased physical activity. Additional research is needed to understand the mechanisms through which narrative increases physical activity during AVG game play.
Nonlinear Calibration of an Infrared Radiometer. (1994)

Abstract : At best, the calibration of an infrared radiometer, also known as a Forward Looking Infrared (FLIR) system, is a complex procedure. Effective calibration must (1) be tailored to the actual radiometer being studied, (2) be carried out to each of the many subsystems involved, (3) relate internal system parameters to physical quantities familiar to the infrared community, and (4) be revisited at some interval to ensure that it is still valid. The details of some of the ideas that form the basis for a valid calibration of the GEC Avionics Ltd Dual Waveband Imaging Radiometer FLIR are discussed. The need for the removal of a systematic error due to magnification optics emission, as described by Braim, is emphasized. Another systematic error, associated with an analysis of FLIR gray scale response based upon linear interpolation from reference temperatures, is examined. A novel method of nonlinear interpolation is presented that is aimed at the reduction or elimination of systematic calibration errors.
Particle Motions in Non-Newtonian Media. II. Poiseuille Flow (1971)

The behavior of rigid and deformable particles suspended in pseudoplastic and elasticoviscous liquids undergoing tube flow was studied. The velocity profiles were more blunted than those obtained for Newtonian fluids and, as in Couette flow, the measured angular velocities of rigid spheres, rods, and discs were in accord with the theory for Newtonian liquids. There was also a drift in the orbit of the cylinders to limiting values corresponding to minimum energy dissipation in the flow. In elasticoviscous liquids, rigid particles migrated across the planes of shear towards the tube axis whereas in pseudoplastic liquids, the opposite was observed, rigid spheres actually coming in contact with the wall. The lateral migration of deformed liquid drops in elasticoviscous fluids was, as in Newtonian systems, towards the tube axis whereas in pseudoplastic liquids the drops attained an equilibrium position between the tube wall and axis. An accumulation of rigid spheres behind an advancing suspension-air meniscus was observed in elasticoviscous media at all initial volume concentrations, the rates of accumulation increasing with flow rate and particle size. In the pseudoplastic fluids, however, there was a dilution at concentrations less than 10% followed by an accumulation at higher values but the rates of accumulation decreased with increasing flow rate and particle size. As in the Couette flow of non-Newtonian suspension, it was not possible to interpret the observed radial migration of the particles in terms of the known rheological properties of the suspending fluids.
Synthesis and ultrastructural studies of styrene-divinylbenzene Polyhipe polymers (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and ultrastructural studies of styrene-divinylbenzene Polyhipe polymersP. Hainey, I. M. Huxham, B. Rowatt, D. C. Sherrington, and L. TetleyCite this: Macromolecules 1991, 24, 1, 117–121Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/ma00001a019https://doi.org/10.1021/ma00001a019research-articleACS PublicationsRequest reuse permissionsArticle Views1776Altmetric-Citations176LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nuclear Factor-κB Activation by the CXC Chemokine Melanoma Growth-stimulatory Activity/Growth-regulated Protein Involves the MEKK1/p38 Mitogen-activated Protein Kinase Pathway (2001)

Melanoma growth stimulatory activity/growth-regulated protein (MGSA/GRO), a CXC chemokine, plays an important role in inflammation, wound healing, growth regulation, angiogenesis, and tumorigenesis. Constitutive expression of MGSA/GROalpha in melanoma tumors is associated with constitutive nuclear factor (NF)-kappaB activity. We show here that either exogenous addition or continuous expression of MGSA/GROalpha in immortalized melanocytes enhances NF-kappaB activation, as well as mitogen-activated protein (MAP) kinase kinase kinase (MEKK) 1, MAP kinase kinase (MEK) 3/6, and p38 MAP kinase activation. Expression of dominant negative M-Ras (S27N), dominant negative MEKK1 (K432M), or specific chemical inhibitors for p38 MAP kinase (SB202190 and SB203580) block MGSA/GROalpha-induced NF-kappaB transactivation, demonstrating that Ras, MEKK1, and p38 are involved in the signal pathways of MGSA/GROalpha activation of NF-kappaB. Expression of dominant active Ras or dominant active MEKK1 alone can also stimulate NF-kappaB activation. The expression of dominant negative MEKK1 inhibits the Ras-induced NF-kappaB activation, suggesting that MEKK1 is a downstream target of Ras. Moreover, MGSA/GROalpha induction of NF-kappaB is independent of the MEK1/ERK cascade, because MGSA/GROalpha failed to increase ERK and ELK activation, and specific chemical inhibitors for MEK1 (PD98059) had no effect on MGSA/GROalpha-enhanced NF-kappaB activation. These data demonstrate that NF-kappaB activation is required for MGSA/GROalpha-induced melanocyte transformation through a Ras/MEKK1/p38 cascade in melanocytes.
Biological management of Fusarium head blight and mycotoxin contamination in wheat (2009)

Fusarium head blight (FHB), caused by Gibberella zeae is a harmful disease of wheat. To manage FHB and mycotoxin contamination in wheat, field experiments were conducted from 2007 to 2008 to evaluate a total of 20 selected bioagents for their ability to inhibit perithecial production of G. zeae and for the control of FHB and deoxynivalenol (DON) contamination, in comparison with the registered fungicide Folicur (tebuconazole). All 20 bioagents significantly reduced the perithecial production compared to the untreated control. Clonostachy rosea strain ACM941 was the most effective treatment, reducing the production of perithecia by 63.7% in 2007 and 67.5% in 2008. These effects were significantly better than Folicur fungicide, which reduced perithecial production by 30.4% and 20.5%, for 2007 and 2008, respectively. When sprayed on to wheat heads, seven of the 20 bioagents significantly reduced the FHB index, one reduced Fusarium damaged kernels (FDK), and six reduced DON content in grains in 2007. ACM941 was the only treatment that significantly reduced FHB index, FDK, and DON, by 46.4%, 29.0% and 28.7%, respectively. Among the six bioagents and three formulated products evaluated in two separate field trials in 2008, ACM941 and its formulated product ACM941-CU were the only treatments that significantly reduced FHB index, FDK, and DON. The treatments reduced FHB index by 30.8% and 31.4%, FDK by 17.8% and 43.8%, and DON by 30.8% and 37.1%, for ACM941 and ACM941-CU, respectively. These effects were less marked than those of the Folicur fungicide that reduced FHB index by 98.8%, FDK by 94.2%, and DON by 92.1%. Results of this study suggest that ACM941 is a promising bioagent against G. zeae and may be used as a control measure in organic farming and in an integrated FHB and DON management program for wheat production.
Efficient Asymmetric Synthesis of <i>abeo-</i>Abietane-Type Diterpenoids by Using the Intramolecular Heck Reaction (2009)

The synthesis of the abeo-abietane-type diterpenoids, i.e., (-)-dichroanal B, (-)-dichroanone, and taiwaniaquinone H, was achieved by using the intramolecular asymmetric Heck reaction. Our synthetic routes required fewer steps and gave a much higher overall yield and ee within shorter steps than those for racemic and antipodal forms reported to date (10, 12, and 13 steps with an overall yield of 50%, 40%, and 39%, and 94%, 98%, and 98% ee, respectively).
The clymer drive system (2006)

The high-speed and the transonic wind tunnels required high-powered (15,000-40,000 hp) fan drives capable of holding very stable constant speed for relatively long periods of time while data was being taken from the wind tunnel. These requirements could best be met by the Clymer drive system which utilizes the wound rotor induction motor with a slip energy recovery system. To recover the slip energy an adjustable speed motor generator set consisting of a synchronous motor driving a DC generator was chosen. Also discusses new Scherbius machines required for special 8-ft transonic pressure wind tunnel that could be pressurized to better simulate flight conditions at transonic speeds at Langley Research Center
Selectively increased growth of fetal hemoglobin-expressing adult erythroid progenitors after brief treatment of early progenitors with transforming growth factor beta (2000)

We have studied the effect of transforming growth factor beta (TGFbeta) on erythropoiesis in cultures from adult peripheral blood, using flow cytometric enumeration of fetal hemoglobin (HbF)-containing cells. TGFbeta caused a dramatic increase in the proportions of cells that accumulated HbF together with adult hemoglobin (HbA) (F+A+ cells). This highly significant (P <.0001) increase in F+ cell proportion was achieved by TGFbeta treatment during the first 4 days of culture and was sustained during further culture expansion in the absence of TGFbeta. The increase in F+ cell proportions did not depend on the cytokine combination (EPO+SCF+IL3, EPO+SCF, EPO+IL3, SCF+IL3) used during the phase of TGFbeta treatment. Increased F+ cell proportions were paralleled by an increased molecular ratio of HbF/ HbF+ HbA, measured by cation exchange high-performance liquid chromatography (HPLC). In addition to the effect on F+ cell proportions, TGFbeta caused a dramatic increase in overall cell division potential. By the time cultures reached terminal growth arrest (12-14 days in controls and 18-26 days after TGFbeta), the overall numbers of F+ cells produced per initially seeded clonogenic cell was approximately 10 times higher in the TGFbeta-treated cultures than in the controls. We propose to investigate whether the TGFbeta-induced increase in relative and absolute numbers of nucleated F+ cells, as demonstrated in vitro, can be translated into increased F+ erythrocytes in vivo, allowing therapeutic application for some beta-hemoglobinopathies. (Blood. 2000;95:2967-2974)
Pseudorandom Active UWB Reflectors for Accurate Ranging (2004)

In this letter, the concept of pseudorandom active reflector, based on the ultra-wideband (UWB) technology, is introduced. It consists of a simple device that repeats a slightly delayed version of the received UWB signal only in certain time intervals according to a suitable pseudorandom time-hopping sequence. An example of application of this device for accurate ranging in precise location systems is given. The advantages of this solution are in the hardware simplicity (only the analog section is present), in the low power consumption of the reflector and in the low timing constraint regarding the relative transmitter and reflector clock rates.
Ischaemic heart disease and the changes in the QRS and ST segments during exercise: a pilot study with a novel vectorcardiographic system (1992)

In order to find new ischaemic parameters, the spatial changes of the Frank vectorcardiogram were continuously analysed with a new, highly precise vectorcardiographic method during, and immediately after a maximal exercise test. This was done in 18 young healthy males, and 18 patients with scintigraphic reversible ischaemia. During exercise, different patterns between the groups were noted for the changes in the mean QRS magnitude in the Y-lead (P less than 0.005), the QRS-integral (P less than 0.05), and the QRS-duration (P less than 0.05). Immediately after exercise, several QRS parameters in the normal group continued to change according to the same pattern as during exercise (P less than 0.05), which was in contrast with the patterns of the ischaemic group (P less than 0.01). The spatial ST difference at J+20 ms discriminated well between the groups, especially when corrected for QRS-magnitudes at rest and heart rate (P less than 0.0005). In short, this pilot study supports previous findings in that changes in amplitude and duration of the QRS complex during exercise discriminated between healthy young males and patients with ischaemic heart disease. Moreover, rapid discriminating changes were seen in the QRS segment during cessation of exercise. These changes deserve attention since they may be of importance for the conflicting results on the diagnostic value of QRS changes during exercise.
Switch Short-Circuit Fault Diagnosis and Remedial Strategy for Full-Bridge DC–DC Converters (2014)

Switch fault diagnosis and remedial actions are an important design aspect for isolated full-bridge dc-dc converters, and they can highly improve reliability of the whole system. In this paper, a fast switch short-circuit fault (SCF) diagnostic method is proposed for the phase-shifted full-bridge (PSFB) converter. The dc-link current and transformer primary voltage are treated as diagnosis criteria. Based on the combination of real-time criteria and switch gate-driver signals, the switch SCF can be identified rapidly, and thus further damage can be avoided. Besides, a remedial action for the faulty PSFB converter is introduced to keep the continuity of the system. The converter under fault can be reconfigured into an asymmetrical half-bridge converter. Moreover, a boost unit, including a switch and a diode, is inserted into between the output rectifier and filter capacitor to compensate the output voltage. The operational principle, design considerations, and implementation are discussed in this paper. Experimental results are shown to verify the validity of theoretical analysis.
Bovine respiratory disease: commercial vaccines currently available in Canada. (2000)

Bovine respiratory disease (BRD) remains a significant cost to both the beef and dairy industries. In the United States, an estimated 640 million dollars is lost annually due to BRD. Losses are largely a result of pneumonic pasteurellosis ("shipping fever"), enzootic pneumonia of calves, and atypical interstitial pneumonia. In Canada, over 80% of the biologics licensed for use in cattle are against agents associated with BRD. The objectives of this paper were (a) to summarize information available concerning commercial vaccines currently used in Canada for protection against BRD, and (b) to provide an easily accessible resource for veterinary practitioners and researchers. Information from the most recent Compendium of Veterinary Products has been tabulated for each vaccine by trade name, according to vaccine type, and the pathogens against which they are designed to protect. Additional information from published articles (peer-reviewed and other) has been provided and referenced.
The fluoroquinolones: How long will their utility last? (2004)

Injudicious use of the fluoroquinolones may result in treatment failure, increased patient morbidity, increased health care cost, and possible patient fatality. Fluoroquinolone-resistant bacteria may also adversely impact the microbiological environment in the hospital, the local community and eventually large geographical regions. Fluoroquinolone resistance develops in a stepwise fashion, and current susceptibility testing methods and recommended MIC susceptible breakpoint values for the United States may fail to identify some bacteria that are resistant due to first step mutations at the fluoroquinolone target site gene sequences. C-8 methoxy- fluoroquinolone compounds are more active against resistant bacteria than the older compounds. Fluoroquinolone resistance relates directly to human and veterinary usage and emerging bacterial resistance poses the single greatest threat to the future survival of the fluoroquinolone drugs as an antibiotic class.
Specifying and Verifying the Correctness of Dynamic Software Updates (2011)

Dynamic software updating (DSU) systems allow running programs to be patched on-the-fly to add features or fix bugs.While dynamic updates can be tricky to write, techniques for establishing their correctness have received little attention.In this paper, we present the first methodology for automatically verifying the correctness of dynamic updates.Programmers express the desired properties of an updated execution using client-oriented specifications (CO-specs), which can describe a wide range of client-visible behaviors.We verify CO-specs automatically by using off-the-shelf tools to analyze a merged program, which is a combination of the old and new versions of a program.We formalize the merging transformation and prove it correct.We have implemented a program merger for C, and applied it to updates for the Redis key-value store and several synthetic programs.Using Thor, a verification tool, we could verify many of the synthetic programs; using Otter, a symbolic executor, we could analyze every program, often in less than a minute.Both tools were able to detect faulty patches and incurred only a factor-of-four slowdown, on average, compared to single version programs.