gebhart/patrepeval huggingface dataset:
Covalently Cross-Linked Perfluorosulfonated Membranes with Polysiloxane Framework (2007)

Proton exchange membranes with low methanol permeability are constructed by incorporating Nafion into a covalently cross-linked network composed of 4,4'-methylenedianiline (MDA) and 3-glycidoxypropyltrimethoxysilane (GPTMS) by ionical cross-linking. The robust framework is full of covalently bonded polysiloxane. The association of Nafion with the cross-linked polysiloxane network results from the ionic interaction between the sulfonic acid groups on Nafion and the amine groups next to polysiloxane. Evidence of the interaction is the shift of the XPS spectra in the S 2p region and the -SO3 stretching band at 1057.8 cm-1 in ATR/FTIR which induced a change of the hydrophilic/hydrophobic microphase separation. The polysiloxane network contributed to the increase in bound water degree, higher proton conductivity at temperatures higher than 70 °C, and greatly decreased methanol permeability. The increasing polysiloxane concentration reduces the methanol permeability to 10-8 cm2/s. With a polysiloxane concentration of 15% MG4, at 30 °C, the composite membrane showed both good proton conductivity (i.e., σ = 3.4 × 10-2 S/cm) and ultralow methanol permeability (i.e., P = 1.1 × 10-8 cm2/s). The composite performed better than Nafion-117 (σ = 4.5 × 10-2 S/cm and P = 2.2 × 10-6 cm2/s) under the same conditions.
Generalized Pipelined Tomlinson–Harashima Precoder Design Methodology With Build-In Arbitrary Speed-Up Factors (2009)

In Tomlinson-Harashima (TH) precoding, the feedback filter (FBF) of a decision feedback equalizer (DFE) and the modulo devices are implemented at the transmitter. Because the TH precoders contain nonlinear feedback loops, it restricts their development for high-speed applications. With very large output levels of the modulo devices in the TH precoders, it is difficult to apply look-ahead and precomputation techniques to pipeline the TH precoders which are usually useful to pipeline IIR filters and DFEs. Among existing works of high-speed TH precoder designs, Gu and Parhi derived two pipelined TH precoder designs (PIPTHP1, 2). The architectures of these two designs seem to be very different and have their-own pros and cons. In this paper, we propose a two-time pipelining scheme to pipeline the TH precoders, which enables us to develop a generalized TH precoder architecture. PIPTHP1 and PIPTHP2 are derived by only applying the first-time and second-time pipelining schemes, respectively. Hence, both the designs can be considered as two extreme cases of the proposed designs. In conclusion, for a given design specification, the proposed scheme can provide tradeoffs between hardware complexity and output dynamic range, which leads to a near-optimal solution based on these design criteria. Therefore, the proposed scheme provides more degrees of freedom for the design trade-offs of high-speed pipelining TH precoders with build-in arbitrary speedup factors.
Targeting aging for disease modification in osteoarthritis (2017)

Although no human clinical trials for osteoarthritis have specifically targeted aging, preclinical studies suggest that targeting cellular senescence and/or mitochondrial dysfunction and the effects of excessive ROS may lead to novel interventions that could slow the progression of osteoarthritis.
Inactivation of <i>Lactobacillus plantarum</i> by Pulsed‐Microwave Irradiation (1997)

ABSTRACT Suspensions of Lactobacillus plantarum cells were subjected to either conventional heating, continuous microwave (CW) or pulsed microwave (PW) irradiation at 50°C for 30 min. Samples exposed to PW showed greater reductions (2 ∼ 4 log) in survival counts than those treated with either conventional heating or CW irradiation. As exposure time increased, PW resulted in a remarkable increase in 260 nm‐absorbing compounds that leaked into the suspending menstruum, as compared to CW or conventional heating, indicating that PW irradiated cells were the most injured. The growth of PW irradiated cells was delayed about 24h and the final acidity of the culture broth was about 60 ∼ 80% that of other cells treated with conventional heating or CW irradiation.
Micro-Raman Line Broadening in Synthetic Carbonated Hydroxyapatite (1986)

Using a Raman microspectrometer, we have recorded Raman spectra of synthetically produced hydroxyapatite samples with varying carbonate contents. The apatites were produced from aqueous solutions at about 40 degrees C. From line-broadening values of the symmetric phosphate stretch, it was concluded that the carbonate substitution in these lattices has a maximum of 4.5 wt %. Both phosphate and hydroxyl ions seem to be involved in the carbonate substitution process.
Outsourcing information services (1991)

Subcontracting of information systems services to third parties ‐ outsourcing ‐ is increasing. There are many reasons why managements might ask why we should not outsource IT activitities. Conversely, theoretical analysis suggests that such a policy change should be entertained with caution. Drawing on information systems research evidence, the author proposes a policy framework for analysis. This can be used in private and public sector organizations and warns against universal prescriptions both within and across organizations.
Inversion of slant stacks using finite‐length record sections (1981)

Inversion of slant stacks for velocity‐depth structures using only the intercept time τ(p) is suboptimal. We propose inverting slant stacks using their integrated power P(p) as an additional constraint. First‐order discontinuities and changes in gradient of velocity‐depth functions, v(z), cause losses of P(p) only for record sections of finite length. In practice then, the observed P(p) may be used to constrain v(z). One advantage of the proposed method is that both τ(p) and P(p) are found directly from the slant stack. Another advantage is that velocity structures are rapidly and accurately inferred. Finally, the method is not subject to biases, as are methods which employ first arrivals only.
Illudalane Sesquiterpenoids from the Soft Coral <i>Alcyonium paessleri</i>:  The First Natural Nitrate Esters (2000)

Fifteen illudalane sesquiterpenoids, alcyopterosins A-O (1-15) have been isolated from the subAntarctic soft coral Alcyonium paessleri which was collected at a depth of 200 m near the South Georgia Islands, and their structures were elucidated by spectroscopic techniques. Eight of these compounds (2, 3, 5-8, 10, and 13) are the first natural nitrate esters, while the other four (1, 4, 11, and 12) are chlorinated. These compounds are as well the first illudalane sesquiterpenoids to be isolated from the marine environment. Compounds 1, 3, 5, and 8 showed mild cytotoxicity toward human tumor cell lines.
Amyotrophic Lateral Sclerosis (1998)

Amyotrophic lateral sclerosis (ALS), otherwise known as Lou Gehrig's or motor neuron disease, is one of several degenerative diseases of the ageing nervous system. Commonly affecting those in their mid-50s and beyond, it is a progressive illness resulting in death within a few years. This text neatly synthesizes the recent explosion of research into this particular condition to construct a detailed and comprehensive overview. From its epidemiology, molecular biology and pathophysiology right through to clinical assessment and care, Professor Eisen and Dr Krieger use their research expertise and extensive clinical experience to provide this practical and thought-provoking account.
Synthesis of 4,4′-dinonyl-2,2′-bithiazole-based copolymers via Pd-catalyzed direct C–H arylation (2012)

Direct arylation polycondensation of a bithiazole derivative with dibromoarylenes gave the corresponding bithiazole-based copolymers using the phosphine-free catalytic system in a short reaction time.
Age‐related changes in lymphokine production related to a decreased number of CD45RB<sup>hi</sup> CD4<sup>+</sup> T cells (1991)

Abstract The ability of CD4 + T cells from CBA/Rij mice to produce interleukin (IL) 2 after stimulation with anti‐CD3, concanavalin A, or the combination of phorbol 12‐myristate 13‐acetate and ionomycin declines during aging. This phenomenon was accompanied by an increased production of IL 4 and interferon‐γ. These age‐related changes in lymphokine production correlated with the decrease in the percentage of CD45RB hi CD4 + T cells from about 80% in 2‐month‐old to about 40% in 27‐month‐old mice. This phenotypic shift was responsible for the decline in IL 2 production, because in young and in old mice CD45RB hi CD4 + T cells were more potent IL 2 producers than CD45RB lo cells. Moreover, old CD45RB hi CD4 + T cells produced less IL 2 than their young counterparts. Proliferative responses by T cells from old mice were lower than those of young mice, regardless whether the cultures were supplemented with IL 2, IL 4 or both lymphokines. As far as CD4 + T cells were concerned, this hyporesponsiveness was found in the CD45RB lo as well as in the CD45RB hi CD4 + T cell population.
MISQUOTING FOUCAULT: PEREC AND CREATIVE EXEGESIS (2000)

MISQUOTING FOUCAULT: PEREC AND CREATIVE EXEGESIS Get access COLIN BELL COLIN BELL Dublin Search for other works by this author on: Oxford Academic Google Scholar French Studies Bulletin, Volume 21, Issue 75, SUMMER 2000, Pages 11–13, https://doi.org/10.1093/frebul/21.75.11 Published: 01 July 2000
Reliable massively parallel symbolic computing : fault tolerance for a distributed Haskell (2013)

any of the information contained in it must acknowledge this thesis as the source of the quotation or information. As the number of cores in manycore systems grows exponentially, the number of failures is also predicted to grow exponentially. Hence massively parallel computations must be able to tolerate faults. Moreover new approaches to language design and system architecture are needed to address the resilience of massively parallel heterogeneous architectures. Symbolic computation has underpinned key advances in Mathematics and Computer Sci-ence, for example in number theory, cryptography, and coding theory. Computer algebra soft-ware systems facilitate symbolic mathematics. Developing these at scale has its own distinctive set of challenges, as symbolic algorithms tend to employ complex irregular data and control structures. SymGridParII is a middleware for parallel symbolic computing on massively parallel High Performance Computing platforms. A key element of SymGridParII is a domain specific language (DSL) called Haskell Distributed Parallel Haskell (HdpH). It is explicitly designed for scalable distributed-memory parallelism, and employs work stealing to load balance dynamically
Asn249Tyr Substitution at the Coenzyme Binding Domain Activates <i>Sulfolobus</i> <i>solfataricus</i> Alcohol Dehydrogenase and Increases Its Thermal Stability (1999)

A mutant of the thermostable NAD+-dependent homotetrameric alcohol dehydrogenase from Sulfolobus solfataricus (SsADH), which has a single substitution, Asn249Tyr, located at the coenzyme binding domain, was obtained by error prone PCR. The mutant enzyme, which was purified from Escherichia coli to homogeneous form, exhibits a specific activity that is more than 6-fold greater than that of the wild type enzyme, as measured at 65 degrees C with benzyl alcohol as the substrate. The oxidation rate of aliphatic alcohols and the reduction rate of aromatic aldehydes were also higher. The dissociation constants for NAD+ and NADH determined at 25 degrees C and pH 8.8 were 3 orders of magnitude greater compared to those of the wild type enzyme. It is thought that the higher turnover of the mutant SsADH is due to the faster dissociation of the modified enzyme-coenzyme complex. Spectroscopic studies showed no relevant changes in either secondary or tertiary structure, while analysis with fluorescent probes revealed a significant increase in surface hydrophobicity for the mutant, with respect to that of the wild type molecule. The mutant SsADH displays improved thermal stability, as indicated by the increase in Tm from 90 to 93 degrees C, which was determined by the apparent transition curves. Kinetic thermal stability studies at pH 9.0 for mutant SsADH showed a marked increase in activation enthalpy compensated by an entropy gain, which resulted in a higher activation barrier against thermal unfolding of the enzyme. Ammonia analysis showed that the Asn249Tyr substitution produced the effect of markedly reducing the extent of deamidation during thermoinactivation, thus suggesting that Asn249 plays a significant role in the mechanism of irreversible thermal denaturation of the archaeal ADH. Furthermore, the decrease in the activating effect by moderate concentrations of denaturants and studies with proteases and chelating agents point to an increase in structural rigidity and a tightening of structural zinc as additional factors responsible for the improved thermal resistance of the mutant enzyme.
Reaction between SiC and W, Mo, and Ta at elevated temperatures (1990)

The stability of W, Mo, and Ta in contact with single-crystal β-SiC at elevated temperatures has been investigated using Auger sputter profiling. All three metals were found to form a thin-mixed layer of metal carbide and silicide upon metal deposition at room temperature. This layer is thought to be the result of surface defects which weaken the Si—C bonds and allow a low-temperature reaction to occur. Upon heating, the Ta readily reacts with the SiC substrate and forms a mixed layer of Ta carbide and silicide at annealing temperatures as low as 400 °C, however, the W/SiC and Mo/SiC systems are stable and change very little after annealing at 850 and 800 °C, respectively.
Calculation of transient 3D eddy current using edge-elements (1990)

The calculation of transient 3-D eddy current using edge elements in the modified A-method is presented. Quadratic 36-edge elements on the 20-node isoparametric elements are proposed. Specifically, the test problems of a square plate and a hollow sphere are solved with linear 12-edge and quadratic 36-edge elements, and the results are compared with the analytical solutions. The results using the two types of elements agree well with each other and with the analytical solution, demonstrating the applicability of these elements for eddy-current calculation. The spatial distributions of the current and magnetic field in elements interpolated by shape functions are approximated better by quadratic elements with fewer degrees of freedom than the linear elements. The accuracy of both types of elements is nearly the same in the test problem of a hollow sphere if the size of the quadratic elements is double that of the linear elements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Estimation of electrode ionomer oxygen permeability and ionomer-phase oxygen transport resistance in polymer electrolyte fuel cells (2013)

The oxygen permeability of perfluorinated and hydrocarbon polymer electrolyte membranes (PEMs; Nafion®, SPEEK and SPSU), which are used as electrolytes and electrode ionomers in polymer electrolyte fuel cells (PEFCs), was estimated using chronoamperometry using a modified fuel cell set-up. A thin, cylindrical microelectrode was embedded into the PEM and used as the working electrode. The PEM was sandwiched between 2 gas diffusion electrodes, one of which was catalyzed and served as the counter and pseudo-reference electrode. Independently, from fuel cell experiments, the oxygen transport resistance arising due to transport through the ionomer film covering the catalyst active sites was estimated at the limiting current and decoupled from the overall mass transport resistance. The in situ oxygen permeability measured at 80 °C and 75% RH of perfluorinated ionomers such as Nafion® (3.85 × 10(12) mol cm(-1) s(-1)) was observed to be an order of magnitude higher than that of hydrocarbon-based PEMs such as SPEEK (0.27 × 10(12) mol cm(-1) s(-1)) and SPSU (0.15 × 10(12) mol cm(-1) s(-1)). The obtained oxygen transport (through ionomer film) resistance values (Nafion® - 1.6 s cm(-1), SPEEK - 2.2 s cm(-1) and SPSU - 3.0 s cm(-1); at 80 °C and 75% RH) correlated well with the measured oxygen permeabilities in these ion-containing polymers.
Planar antenna arrays on LTCC-multilayer technology (2001)

This paper present the design and prototyping of different 24.125 GHz low temperature co-fired ceramic (LTCC) aperture-coupled patch antenna arrays for ISM-band applications. Thorough analysis of material loss, gain and bandwidth shows the LTCC material to be well suited for realising antenna arrays up to the typical ceramic wafer size of about 15/spl times/15 cm/sup 2/ (6/spl times/6 in/sup 2/). Some aspects of the prototyping process like the implementation of meshed ground planes and the realisation of integrated thick film resistors are discussed. Various measurements of far field patterns and gain are presented and found to be in good agreement with the simulation results. Finally, the measurement results of different antenna prototypes show very good reproducibility.
Accelerating a TV based JPEG decompression algorithm with Cuda (2011)

In previous works, we have have developed a mathematical model for artifactfree decompression of JPEG images. There, the problem of finding an artifactfree decompression for a given JPEG compressed image is related to a convex minimization problem. We use a primal-dual algorithm to solve this problem, for which we have developed a Matlab and C++ implementation. Since calculation time is crucial for the practical application of this model, we want to use the CUDA programming language in order to implement our code for graphic processor units (GPUs) for a further decrease of calculation time. On the following we will address this issue. We start by giving a short introduction to the JPEG compression standard [4], explaining the basic principles of our model and introducing a primal-dual algorithm used to solve the minimization problem [1]. For a more detailed mathematical treatment of the problem we refer to [2],[3]. In the second section, we describe the CUDA implementation of the algorithm. The last section compares calculation times for different implementations and images.
Preparation and chemistry of PhI+C.tplbond.CI+Ph.cntdot.2-OTf, bis[phenyl[[(trifluoromethyl)sulfonyl]oxy]iodo]acetylene, a novel difunctional acetylene, bis(iodonium) species and a stable C2-transfer agent (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and chemistry of PhI+C.tplbond.CI+Ph.cntdot.2-OTf, bis[phenyl[[(trifluoromethyl)sulfonyl]oxy]iodo]acetylene, a novel difunctional acetylene, bis(iodonium) species and a stable C2-transfer agentPeter J. Stang and Viktor V. ZhdankinCite this: J. Am. Chem. Soc. 1991, 113, 12, 4571–4576Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/ja00012a028https://doi.org/10.1021/ja00012a028research-articleACS PublicationsRequest reuse permissionsArticle Views1372Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
MTA1 Coregulator Regulates LPS Response via MyD88-dependent Signaling* (2010)

Although metastasis tumor antigen 1 (MTA1) contributes to the responsiveness of macrophages to LPS, the underlying mechanism remains unknown. Here, we investigated the role of MTA1 in the regulation of expression and function of MyD88, a proximal component of NF-κB signaling. We discovered that MTA1 targets MyD88 and that MyD88 is a NF-κB-responsive gene in LPS-stimulated macrophages. We found that MTA1 is required for MyD88-dependent stimulation of NF-κB signaling and expression of proinflammatory cytokines such as IL-1β, MIP2, and TNF-α as MTA1 depletion leads to a substantial reduction in the expression of NF-κB target genes. In addition, LPS-mediated stimulation of MyD88 transcription was accompanied by an enhanced recruitment of MTA1, RNA polymerase II, and p65RelA complex to the NF-κB consensus sites in the MyD88 promoter. Interestingly, the recruitment of both MTA1 and MyD88 expression is effectively blocked by NF-κB inhibitor parthenolide. Selective knockdown of MyD88 by a dominant negative mutant of MyD88 or selective siRNA also impairs the ability of LPS to stimulate the NF-κB target genes. These findings reveal an inherent coregulatory role of MTA1 upon the expression of MyD88 and suggest that MTA1 regulation of MyD88 may constitute at least one of the mechanisms by which MTA1 stimulates LPS-induced NF-κB signaling in stimulated macrophages.
Positive regulation in the general amino acid control of Saccharomyces cerevisiae. (1983)

Starvation of yeast for a single amino acid leads to derepression of enzymes in many different amino acid biosynthetic pathways. This general control is regulated by several transacting genes. Mutations in the TRA3 gene result in constitutive derepression, whereas mutations in AAS genes lead to the inability to derepress. We have isolated aas mutations as suppressors of the tra3-1 mutation. Some of these suppressors are alleles of AAS2 and others define a heretofore unidentified gene, AAS3. We have studied the regulatory behavior of strains containing both aas and tra3 mutations and strains containing the cloned AAS genes in high copy number. Either aas1- or aas2- in combination with tra3- has the Tra- phenotype, whereas aas3- in combination with tra3- has the Aas- phenotype. These interactions suggest that the AAS1 and AAS2 products act indirectly to bring about derepression by disabling the repressive effect of TRA3, whereas the AAS3 product functions more directly and is required even in the absence of the TRA3 function. When present in high copy number, the AAS3 gene complements mutations in AAS1 and AAS2, whereas AAS1 and AAS2 only complement their cognate mutations. Taken together these data suggest that AAS1 and AAS2 are negative regulators of TRA3, which in turn is a negative regulator of AAS3. AAS3 is a positive regulator, which is required for the general control response. This model of negative and positive interactions is formally identical to those proposed for the regulation of the galactose and phosphatase systems in yeast.