gebhart/patrepeval huggingface dataset:
<i>AKR1</i>Encodes a Candidate Effector of the Gβγ Complex in the<i>Saccharomyces cerevisiae</i>Pheromone Response Pathway and Contributes to Control of both Cell Shape and Signal Transduction (1996)

Mating pheromones of Saccharomyces cerevisiae control both signal transduction events and changes in cell shape. The G beta gamma complex of the pheromone receptor-coupled G protein activates the signal transduction pathway, leading to transcriptional induction and cell cycle arrest, but how pheromone-dependent signalling leads to cell shape changes is unclear. We used a two-hybrid system to search for proteins that interact with the G beta gamma complex and that might be involved in cell shape changes. We identified the ankyrin repeat-containing protein Akr1p and show here that it interacts with the free G beta gamma complex. This interaction may be regulated by pheromone, since Akr1p is excluded from the G alpha beta gamma heterotrimer. Both haploid and diploid cells lacking Akr1p grow slowly and develop deformed buds or projections, suggesting that this protein participates in the control of cell shape. In addition, Akr1p has a negative influence on the pheromone response pathway. Epistasis analysis demonstrates that this negative effect does not act on the G beta gamma complex but instead affects the kinase cascade downstream of G beta gamma, so that the kinase Ste20p and components downstream of Ste20p (e.g., Ste11p and Ste7p) are partially activated in cells lacking Akr1p. Although the elevated signalling is eliminated by deletion of Ste20p (or components downstream of Ste20p), the growth and morphological abnormalities of cells lacking Akr1p are not rescued by deletion of any of the known pheromone response pathway components. We therefore propose that Akr1p negatively affects the activity of a protein that both controls cell shape and contributes to the pheromone response pathway upstream of Ste20p but downstream of G beta gamma. Specifically, because recent evidence suggests that Bem1p, Cdc24p, and Cdc42p can act in the pheromone response pathway, we suggest that Akr1p affects the functions of these proteins, by preventing them from activating mating-specific targets including the pheromone-responsive kinase cascade, until G beta gamma is activated by pheromone.
Playback restart in interactive streaming video applications (1997)

Low latency is crucial in networked multimedia applications such as on-demand streaming audio and video. In this paper we consider the problem of restarting or resuming playback following an interactive operation such as fast forward, rewind, or indexed jump in stored on-demand video. We present two approaches to restart playback after an interactive operation, and develop algorithms to compute the latencies incurred in restarting playback. Using long MPEG-1 traces, with an optimal smoothing technique to transmit data for regular playback, we demonstrate that the latencies incurred under our approaches are very small. We next examine the latencies incurred when restarting playback in a video server under two policies for sharing its bandwidth: (a) one in which only regular playback bandwidth is available to restart playback and (b) one in which additional free server bandwidth (if any) is accessible. We find playback restart latencies to be similarly low under both policies, suggesting that the simpler approach (a) is sufficient.
16. The formula of hypophosphoric acid (1933)

F. Bell and S. Sugden, J. Chem. Soc., 1933, 48 DOI: 10.1039/JR9330000048
Design, Synthesis and Antimycobacterial Activity of Novel Imidazo[1,2-a]pyridine Amide-Cinnamamide Hybrids (2015)

We report herein the design and synthesis of a series of novel imidazo[1,2-a]pyridine amide-cinnamamide hybrids linked via an alkyl carbon chain. All 38 new hybrids were evaluated for their antimycobacterial activity against M. tuberculosis (MTB) H37Rv ATCC 27294 using the microplate Alamar Blue assay (MABA). Although the hybrids are less active than the two reference compounds, the promising activity (MICs: 4 μg/mL) of 2,6-dimethylimidazo[1,2-a]pyridine amide-cinnamamide hybrids 11e and 11k could be a good starting point to further find new lead compounds against multi-drug-resistant tuberculosis.
Quantitative Proteomic Analysis of Escherichia coli Heat-Labile Toxin B Subunit (LTB) with Enterovirus 71 (EV71) Subunit VP1 (2016)

The nontoxic heat-labile toxin (LT) B subunit (LTB) was used as mucosal adjuvant experimentally. However, the mechanism of LTB adjuvant was still unclear. The LTB and enterovirus 71 (EV71) VP1 subunit (EVP1) were constructed in pET32 and expressed in E. coli BL21, respectively. The immunogenicity of purified EVP1 and the adjuvanticity of LTB were evaluated via intranasal immunization EVP1 plus LTB in Balb/c mice. In order to elucidate the proteome change triggered by the adjuvant of LTB, the proteomic profiles of LTB, EVP1, and LTB plus EVP1 were quantitatively analyzed by iTRAQ-LC-MS/MS (isobaric tags for relative and absolute quantitation; liquid chromatography-tandem mass spectrometry) in murine macrophage RAW264.7. The proteomic data were analyzed by bioinformatics and validated by western blot analysis. The predicted protein interactions were confirmed using LTB pull-down and the LTB processing pathway was validated by confocal microscopy. The results showed that LTB significantly boosted EVP1 specific systematic and mucosal antibodies. A total of 3666 differential proteins were identified in the three groups. Pathway enrichment of proteomic data predicted that LTB upregulated the specific and dominant MAPK (mitogen-activated protein kinase) signaling pathway and the protein processing in endoplasmic reticulum (PPER) pathway, whereas LTB or EVP1 did not significantly upregulate these two signaling pathways. Confocal microscopy and LTB pull-down assays confirmed that the LTB adjuvant was endocytosed and processed through endocytosis (ENS)-lysosomal-endoplasmic reticulum (ER) system.
Behavioral and neuroplastic effects of low-frequency rTMS of the unaffected hemisphere in a chronic stroke patient: A concomitant TMS and fMRI study (2013)

Repetitive Transcranial Magnetic Stimulation (rTMS) ameliorates motor and neuropsychological deficits following stroke, but little is known about the underlying neuroplasticity. We investigated neuroplastic changes following 5 days of low-frequency rTMS on the intact motor cortex to promote motor recovery in a chronic patient with subcortical stroke. The feasibility of administering multiple treatments was also assessed 6 months later by applying the same protocol over the patient's parietal cortex to improve visuospatial disorders. Behavioral improvements and no adverse events were observed. Neuroimaging findings indicated that motor symptoms amelioration was associated with downregulation and cortical reorganization of hyperactive contralesional hemisphere.
In Vivo Imaging of Activated Endothelium Using an Anti-VCAM-1 Magnetooptical Probe (2005)

It has been suggested that vascular cell adhesion molecule-1 (VCAM-1) could serve as an early marker for inflammation of the endothelium. The ability to noninvasively image VCAM-1 could thus be a useful tool to diagnose a number of inflammatory diseases at early stages. Here we demonstrate that magnetooptical nanoparticles conjugated to anti-VCAM-1 antibodies can be used to specifically detect VCAM-1 expression on endothelial cells in culture and in vivo. Elevated VCAM-1 expression was detected on cultured murine heart endothelial cells by both fluorescence and magnetic resonance, while only basal expression levels were detected on murine dermal endothelial cells. Intravital microscopy of a murine inflammatory model injected with the VCAM-1 targeted nanoparticles revealed specific labeling of the activated endothelium, with labeling kinetics yielding a maximum vessel wall signal 6 h after injection. In contrast, nontargeted nanoparticles did not exhibit any specific labeling of the endothelium. These studies suggest that the developed nanoparticle would be useful for MR and optical detection of activated endothelium.
Gestión de riesgos financieros empresariales (2001)

Con este artículo se pretende plantear la filosofía de la gestión de riesgos, definir su alcance y explicar por qué puede añadir valor a la empresa. La gestión de riesgos constituye otra alternativa dentro del campo de acción del ingeniero industrial, el cual puede desempeñarse como analista o auditor de empresas que tomen decisiones a partir de esta herramienta financiera.
Decentralized learning in finite Markov chains (1985)

The principal contribution of this paper is a new result on the decentralized control of finite Markov chains with unknown transition probabilities and rewards. One decentralized decision maker is associated with each state in which two or more actions (decisions) are available. Each decision maker uses a simple learning scheme, requiring minimal information, to update its action choice. It is shown that, if updating is done in sufficiently small steps, the group will converge to the policy that maximizes the long-term expected reward per step. The analysis is based on learning in sequential stochastic games and on certain properties, derived in this paper, of ergodic Markov chains.
Significance of human neutrophil antigen‐2a (NB1) expression and neutrophil number in pregnancy (2004)

HNA-2a expression may increase soon after fertilization. In this study, the results indicate that the change in the number of neutrophils and monocytes is related to HNA-2a expression.
Electrochemical reactions of semiconductors (1976)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Richard Williams; Electrochemical reactions of semiconductors. J. Vac. Sci. Technol. 1 January 1976; 13 (1): 12–18. https://doi.org/10.1116/1.568806 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science and Technology Search Advanced Search |Citation Search
Quenching of fluorescence in small molecules (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleQuenching of fluorescence in small moleculesJeffrey I. SteinfeldCite this: Acc. Chem. Res. 1970, 3, 9, 313–320Publication Date (Print):September 1, 1970Publication History Published online1 May 2002Published inissue 1 September 1970https://pubs.acs.org/doi/10.1021/ar50033a005https://doi.org/10.1021/ar50033a005research-articleACS PublicationsRequest reuse permissionsArticle Views502Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Agraphia in Dementia of the Alzheimer Type (1992)

This study describes graphic errors made in writing a simple sentence in 368 healthy older adults and individuals in different stages of dementia of the Alzheimer type. Errors of agraphia were present in both healthy and demented people and, in general, increased with the severity of dementia. The errors of agraphia were not correlated with measures of aphasia or psychometric measures of language and motor performance. Writing skill may represent procedural memory, and agraphia errors indicate alterations in long-term memory in dementia of the Alzheimer type.
Enantioselective Total Synthesis of (+)-6-<i>epi</i>-Mevinolin and Its Analogs. Efficient Construction of the Hexahydronaphthalene Moiety by High Pressure-Promoted Intramolecular Diels−Alder Reaction of (<i>R</i>,2<i>Z</i>,8<i>E</i>,10<i>E</i>)-1-[(<i>tert</i>-Butyldimethylsilyl)oxy]-6-methyl-2,8,10-dodecatrien-4-one (1997)

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, (+)-6-epi-mevinolin (2a) and (+)-6-epi-4a,5-dihydromevinolin (2b), were prepared by combining two nonracemic units, phosphonate 3 and decalin 4, which were prepared from enantiopure 3-substituted pentanedioic acid monoesters 5a and 5b, respectively. Each acid was synthesized from cyclic anhydrides 7a and 7b by diastereoselective ring opening by means of (S)-benzyl mandelate as a common chiral auxiliary. The construction of decalin moiety 4 was accomplished by asymmetric intramolecular Diels−Alder (IMDA) reaction of nonracemic trienone 6 bearing a methyl group as a chiral controller. The IMDA diastereoselectivity of trienone 6 is discussed in terms of the configuration of (E)- and (Z)-dienophiles which are activated by an endogenous carbonyl group. The IMDA reaction of (R)-(Z)-6 under high pressure is highly selective and gives cis-decalins exclusively with preferential formation of 4 over 16. The inhibitory activity of (+)-6-epi-mevinolin (2a) and several analogs against HMG-CoA reductase was compared with mevinolin (1b). (+)-6-epi-Mevinolin (2a) was shown to be half as potent as mevinolin (1b) while (+)-6-epi-4a,5-dihydromevinolin (2b) was as potent as mevinolin.
Implementing the PATRICIA data structure for compression algorithms with finite size dictionaries (1992)

On the basis of the PATRICIA suffix tree, the author presents a simple way to implement a data structure for searching and updating the finite size dictionary in compression algorithms. For updating, each time a new entry is inserted into the tree, the internal node keeps the latest position rather than its old one. As in the normal PATRICIA tree, all the external nodes are put into a buffer, which shifts circularly. After the leaf nodes are exhausted, the oldest leaf node is deleted and put into the tree to represent new entries, and its old position is kept with a pointer. In this way, the updating procedure for all the internal nodes can be bypassed. Therefore, whenever the finite size dictionary is full, the spaces below the points of old positions can be replaced by new input data.
Fuzzy supervisory control of manufacturing systems. (2004)

A supervisory controller is derived for scheduling (single/multiple-part-type, reentrant) production networks. The supervisory controller is used to tune a set of lower level distributed fuzzy control modules that reduce work-in-process (WIP) and synchronize the production system&apos;s operation. The overall production-control system is viewed as a two-level surplus-based system with the overall control objective to keep the WIP and cycle time as low as possible, while maintaining quality of service by keeping backlog to acceptable levels. The production rate in each production stage is controlled to satisfy demand, avoid overloading, and eliminate machine starvation or blocking. The system&apos;s improvement is demonstrated using a set of performance measures. Extensive simulation results show that the supervisory controller, when compared with the single-level distributed fuzzy controllers reduces WIP and cycle time while keeping backlog to acceptable levels.
Ground-based remote profiling in atmospheric studies: an overview (1994)

Over the last 25 years, ground-based remote profiling has found increasing applications in atmospheric studies where its high vertical and temporal resolution and extended vertical coverage are giving scientists a clearer understanding of atmospheric processes in the troposphere. The authors describe the current status of techniques for vertical profiling of mean wind speeds, temperature, and humidity, and discuss options for combining them.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Comparison of windowing schemes for speech coding (2015)

The majority of speech coding algorithms are based on the code excited linear prediction (CELP) paradigm, modelling the speech signal by linear prediction. This coding approach offers the advantage of a very short algorithmic delay, due to the windowing scheme based on rectangular windowing of the residual of the linear predictor. Although widely used, the performance and structural choices of this windowing scheme have not been extensively documented. In this paper we introduce three alternative windowing schemes, as alternatives to the one already used in CELP codecs. These windowing schemes differ in their handling of transitions between frames. Our subject evaluation shows that omitting the error feedback loop yields an increase in perceptual quality at scenarios with high quantization noise. In addition, objective measures show that while error feedback improves the accuracy slightly at high bitrates, at low bitrates it causes a degradation in quality, resulting in a lower SNR.
Highly Parallel Droplet Sample Preparation for Single Cell Proteomics v2 (2022)

Protocol for preparing single cells for mass-spec analysis by nPOP as described by Leduc et al., 2021, 2022 DOI: 10.1101/2021.04.24.441211. nPOP uses piezo acoustic dispensing to isolate individual cells in 300 picoliter volumes and performs all subsequent preparation steps in small droplets on a fluorocarbon-coated slide. This design enables simultaneous sample preparation of thousands of single cells in a single batch. This includes lysing, digesting, and labeling individual cells in volumes below 20 nl. nPOP supports different experimental designs including label free analysis, TMT 18plex with carrier, mTRAQ, and TMT-10plex for TOF instruments (see steps). Data, resources and additional information: https://scp.slavovlab.net/Leduc_et_al_2022 and https://scp.slavovlab.net/nPOP Andrew Leduc presented a detailed workflow of nPOP at the 4th Single Cell Proteomics Conference available on YouTube: https://youtu.be/DJ1U_KpMNcY The protocol uses the CellenONE system for liquid handling and cell sorting and assumes basic level of familiarity and training on the CellenONE. If there are any questions, please email leduc.an@northeastern.edu
A New Computer Based Integrated Distance Relay For Parallel Transmission Lines (1985)

Simultaneous single phase faults on different phases of parallel transmission lines may cause three phase trips on both lines although the faults in question do not warrant three phase trip. When such lines constitute the only link between a power plant and the remaining power system, misoperation of relays often leads to a loss of generators through loss of synchronism. This problem has been analyzed, and a new integrated relaying principle proposed which produces a secure decision to trip only the faulted phases in cases of complex simultaneous faults. Results of simulated relay performance are given. Also included are some preliminary considerations regarding computer implementation of the new relay.
A NOTE ON THE TAXEVADING FIRM (1995)

This note develops a general model of tax evasion applicable to any form of evasion that might be practiced by the firm. It shows that the firm's activity level is always separable from the evasion decision, that a tax rate increase must always decrease the firm's statement deviation from the true value of its tax base (or of a magnitude deductible from its tax base), and that the amount of tax evaded can never increase; at most, when the firm acts as a withholding agent, it will remain unchanged. The results are applied to the case of payroll tax evasion.
Multi-Impairment Monitoring at 320 Gb/s Based on Cross-Phase Modulation Radio-Frequency Spectrum Analyzer (2010)

We introduce a scheme for multi-impairment performance monitoring at ultrahigh bit rates based on cross-phase modulation (XPM) in a nonlinear waveguide. We demonstrate that we can simultaneously monitor in-band optical signal-to-noise ratio and group velocity dispersion at bit rates of 320 Gb/s (return-to-zero format) from a single measurement. Our approach retrieves the autocorrelation of the signal via the radio-frequency (RF) spectrum, which is captured with an XPM-based RF spectrum analyzer in a highly nonlinear fiber.
High-Resolution, Far-Field, and Passive Temperature Sensing up to 700 °C Using an Isolated ZST Microwave Dielectric Resonator (2015)

This paper presents a high-resolution, wireless and passive temperature measurement system up to 700 °C. The sensor is based on a metallization-free monolithic microwave dielectric resonator composed of zirconium tin titanate (Zr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.8</sub> Sn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.2</sub> TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> ) operating at 2.37 GHz. The external electromagnetic fields of the tracked single mode are adequate for the far-field coupling without the need to use any conducting part on the sensor surface. The measurements are conducted in a light weight refractory bricks oven at a distance of 1.20 m between the sensor and a reader planar antenna connected to a time-domain RADAR-based interrogation unit. This method allows to retain a quality factor (Q) higher than 670 at 700 °C, while the Q-factor from other electromagnetic cavity or microwave dielectric resonators degrades below 100, hence limiting the sensing resolution and increasing the sensitivity to the environmental echoes. The effect of temperature on the tracked sensor resonance frequency, signal-to-noise ratio, Q-factor, thermal expansion, and sensing resolution is presented. The concept is suitable for applications working in extreme environments, such as aerospace applications.