gebhart/patrepeval huggingface dataset:
Distributed management with mobile components (2003)

The increasing importance of networks and the growing numbers of devices and services that run on them necessitate effective network and systems management. The traditional centralized management paradigm alone is no longer sufficient for effective management solutions, primarily as it does not scale well. Distribution of management tasks is a promising approach. The distributed management framework (DMF) presented in this paper provides an environment which allows a broad range of management tasks to move and run anywhere within the managed system. In our approach, management tasks are lightweight applications that can be dynamically configured and downloaded as required, reducing the load on managed resources and simplifying the problem of management software updates. We present an object-oriented, Java-based implementation of the DMF and describe applications developed on this platform.
Sp17 gene expression in myeloma cells is regulated by promoter methylation (2004)

The mechanisms underlying sperm protein 17 (Sp17) gene expression in myeloma cells remained unclear. Using reverse transcription-polymerase chain reaction (RT-PCR), Sp17 transcripts were detected in ARK-B, ARP-1, RPMI-8226 and KMS-11 but not in H929, IM-9, MM1-R and U266 cells. Using a panel of primer pairs in methylation-sensitive PCR to amplify overlapping gene segments, our screening studies showed that the HpaII sites at -359 and -350 are involved in the regulation of Sp17 gene expression. To confirm the differences in methylation status between Sp17-positive and Sp17-negative cell lines, KMS-11 cells (Sp17-positive) and IM-9 cells (Sp17-negative) were subjected to the more accurate method of bisulphite conversion. KMS-11 cells were more hypomethylated at these HpaII sites of exon 1 compared to IM-9 cells, indicating the association of hypomethylated promoter with Sp17 gene expression. In addition, the level of methylation at other CpG sites within the promoter sequence was also higher in IM-9 than KMS-11. Exon 1 was cloned into a reporter vector, pCAT*3 Enhancer. Chloramphenicol acetyl transferase (CAT) activity was restored in cells transfected with the recombinant plasmid, indicating the promoter function of exon 1. Exposure of Sp17-negative cell lines to the hypomethylating agent, 5-azacytidine, resulted in the upregulation of Sp17 gene expression. Our results therefore provide evidence for the regulation of Sp17 gene expression by promoter methylation.
A little knowledge goes a long way: faster detection of compromised data in 2-D tables (1990)

A reexamination is made of the problem of protecting sensitive data in an n by n table of integer statistics, when the nonsensitive data are made public along with the row and column sums for the table. Consideration is given to the problem of computing the tightest upper bounds on the values of sensitive (undisclosed) cells. These bounds, together with tightest lower bounds (which can be efficiently computed), define precisely the smallest intervals that an adversary can deduce for the missing sensitive cell values. Small intervals compromise the security of the undisclosed data, and in some cases violate laws on public data disclosure. It is observed that the number of initial needed bounds can be reduced from O(n log n) to 2n-1 by exploiting a recent result of C.K. Cheung and T.C. Hu (1988).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Biogenesis of the vitronectin receptor in human endothelial cell: evidence that the vitronectin receptor and GPIIb-IIIa are synthesized by a common mechanism (1989)

Human endothelial cells express a membrane glycoprotein alpha beta heterodimer similar to the human platelet glycoprotein IIb-IIIa complex (GPIIb-IIIa). This noncovalently associated complex is the vitronectin receptor (VNR). These two receptors belong to the cytoadhesin family and share the same beta subunit. They express different recognition specificities: platelet GPIIb-IIIa is a receptor for fibrinogen, fibronectin, and von Willebrand factor (vWF), whereas VNR is a receptor for vitronectin, and is possibly a receptor for fibrinogen and vWF. We analyzed the biosynthesis of the endothelial cell VNR. Our data show that VNR alpha is a two-chain protein which is biosynthesized as a single-chain precursor: the pro-VNR alpha. Pro-VNR alpha forms a complex with VNR beta, and this association occurs prior to the Golgi- mediated processing of the oligosaccharide side chains. Mature VNR beta is glycosylated by not fully processed oligosaccharide side chains because it remains endoglycosidase H (endo H) sensitive, even when the complex is expressed on the cell surface. This characteristic appears as a common feature for the members of the cytoadhesin family. These results indicate that although VNR and GPIIb-IIIa are biosynthesized in different cells, their expression is controlled by similar mechanisms, providing further support for the concept that the cytoadhesin family constitutes a distinct group of adhesion receptors.
The Structure Sensitivity of the U6+ Ion Luminescence in Oxides (1977)

This paper discusses how the luminescence of the U6+ ion in oxides is influenced by the crystal structure and the chemical composition of the host lattice. The vibrational fine structure of the emission band, the decay time, and the thermal quenching temperature of the luminescence are the properties which we concentrate on. Starting point of the discussion is the perfectly cubic group, the emission of which corresponds to a zero‐phonon magnetic‐dipole transition followed by mainly one‐photon vibronics. The influence of symmetry lowering on this emission is described. This influence becomes of striking importance if the U6+ ion is introduced in host lattices containing edge‐sharing groups. Finally some general aspects of the vibrational fine structure, in particular the length of the progression in , are discussed. The strong dependence of the thermal quenching temperature of the U6+ luminescence on the host lattice can be explained using a configurational‐coordinate diagram with three parabolas.
Structural and functional properties of a 69-kilodalton outer membrane protein of Bordetella pertussis. (1988)

A-69-kDa outer membrane protein present on virulent Bordetella pertussis cells is recognized by the agglutinating monoclonal antibodies BPE3, BPD8, and BPE8. The amino acid composition of this protein, purified from heat extracts of B. pertussis BP353 cells, is different from that of the two major fimbrial antigens of B. pertussis, which is consistent with its being a nonfimbrial protein based on other criteria. Western blot analysis using the monoclonal antibody BPE3 demonstrated that a slightly larger but antigenically cross-reactive protein is also expressed by Bordetella bronchiseptica and Bordetella parapertussis. In addition, a large molecular weight species of about 180-kDa is found in outer membrane extracts of B. bronchiseptica which may represent a precursor form of the protein or indicate that the protein can exist as an oligomer. The monoclonal antibody BPD8 directed against the 69-kDa protein almost completely inhibited the enzymatic activity of adenylate cyclase purified from B. pertussis and also inhibited the intoxication of mammalian cells by this enzyme. Since little enzymatic activity was found associated with the purified 69-kDa protein, these data suggest a role for the 69-kDa protein in regulating the adenylate cyclase toxin of B. pertussis. An additional monoclonal antibody directed against the 69-kDa protein, BPE8, decreases lymphocytosis and delays death in mice receiving a respiratory challenge of virulent B. pertussis cells. These studies suggest that further investigation into the role of this protein as a protective antigen and vaccine candidate is warranted.
Displacement of Lewis Acid Gases - PF<sub>5</sub>, BF<sub>3</sub> and SiF<sub>4</sub> from Their Ammonium, Alkali Metal and Pyridinium Fluorocomplexes by Sulphur Trioxide at Room Temperature (1992)

Abstract Lewis acid gases, PF5, BF3 and SiF4 are liberated from their ammonium, alkali metal and pyridinium fluorocomplexes, NH4PF6, NaPF6, KPF6, C5H5NHPF6, C5H5NHBF4 and (C5H5NH)2SiF6, when treated with sulphur trioxide at room temperature. The dissociated ammonium/alkali metal fluorides as well as the pyridinium fluoride react further with the excess sulphur trioxide to form the corresponding fluorosulphates. The products, Lewis acid gases and the fluorosulphates, have been 19 characterised by I. R., F NMR and wet chemical analysis. This is the first report of the synthesis of these gases from pyridinium fluorosulphate at room temperature in good yields.
Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location (2008)

During adhesion and spreading, cells form micrometer-sized structures comprising transmembrane and intracellular protein clusters, giving rise to the formation of what is known as focal adhesions. Over the past two decades these structures have been extensively studied to elucidate their organization, assembly, and molecular composition, as well as to determine their functional role. Synthetic materials decorated with biological molecules, such as adhesive peptides, are widely used to induce specific cellular responses dependent on cell adhesion. Here, we focus on how surface patterning of such bioactive materials and organization at the nanoscale level has proven to be a useful strategy for mimicking both physical and chemical cues present in the extracellular space controlling cell adhesion and fate. This strategy for designing synthetic cellular environments makes use of the observation that most cell signaling events are initiated through recruitment and clustering of transmembrane receptors by extracellular-presented signaling molecules. These systems allow for studying protein clustering in cells and characterizing the signaling response induced by, e.g., integrin activation. We review the findings about the regulation of cell adhesion and focal adhesion assembly by micro- and nanopatterns and discuss the possible use of substrate stiffness and patterning in mimicking both physical and chemical cues of the extracellular space.
Synthesis of AlN Powder by Carbothermal Reduction-Nitridation Method (1993)

The effect of additives on carbothermal reduction-nitridation was investigated for the preparation of AlN powders from the Al2O3-C-N2 system. According to the role of additives in nitridation, they were divided into three categories: “promote”, “have no effect” and “disturb”. In particular, CaF2 was an excellent nitridation promoter providing spherical AlN particles. The apparent activation energy of nitridation for CaF2 addition was 190kJ/mol, while those for Y2O3, Yb2O3 and without additive were around 250kJ/mol. CaF2, Y2O3, Yb2O3 and transition metal compounds strongly affected AlN grain morphologies, supplying spherical and rod-like shapes of AlN. It was estimated that the reduction-nitridation proceeds through the formation of intermediates like CaF2⋅5Al2O3 and Y-aluminates.
3-D self-assembling and actuation of electrostatic microstructures (2001)

An advanced three-dimensional (3-D) self-assembling technique of surface micro-machined polysilicon structures is presented here for the realization of dedicated actuators for optical applications such as micro-mirror arrays with large deflection angles. Three-dimensional polysilicon microparts are self-assembled by beam buckling induced by integrated scratch drive actuators (SDAs). With this technique, 380/spl times/250 /spl mu/m/sup 2/ microplates were lifted 30 /spl mu/m above the substrate plane. Once the assembling is performed, the 3-D shapes were held permanently by an integrated mechanical lock. Subsequent to the 3-D assembling, micro-mirrors were successfully actuated by biasing buried electrodes. Controlled motion up to /spl plusmn/15/spl deg/ rotation was measured and analyzed by means of analytical models. Long-term actuations were carried out without any observable change, even for 0.5-/spl mu/m thin polysilicon structures. This self-assembling technique of 3-D devices from surface micro-machining opens new integration capabilities and new applications for micro-opto-electro-mechanical systems (MOEMS).
BNB self-routing permutation network (2002)

A self-routing permutation network capable of routing all n factorial permutations of its n inputs to its n outputs is presented. The network implements the binary radix sorting on the structure of the generalized baseline network, a modified model of the original baseline network. The network has O(N log/sup 3/ N) hardware complexity and O(log/sup 3/ N) delay time for N-inputs. The network makes use of the localized bit information instead of the global information in routing procedure. This strategy leads to the reduction of both the hardware and the delay time compared with other comparable networks. The resulting hardware is simple, and has a good regularity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Frequency tunable S-band resonator using nematic liquid crystal (2012)

A tunable resonator based on change of substrate permittivity is fabricated using a new high performance liquid crystal GT3-23001. The results show a measured frequency tuning range of 8.2% compared with a simulated 8.5% around a centre frequency of 2.8 GHz, with a lower insertion loss compared to standard liquid crystals.
Development of a universal dual-bolus injection scheme for the quantitative assessment of myocardial perfusion cardiovascular magnetic resonance (2011)

The universal dual-bolus injection scheme does not require sophisticated double-head power injector function and is a feasible technique to obtain reasonable arterial input function curves for absolute MBF quantification.
Dephosphorylation of Human Cyclin-dependent Kinases by Protein Phosphatase Type 2Cα and β2 Isoforms (2000)

We previously reported that the activating phosphorylation on cyclin-dependent kinases in yeast (Cdc28p) and in humans (Cdk2) is removed by type 2C protein phosphatases. In this study, we characterize this PP2C-like activity in HeLa cell extract and determine that it is due to PP2C beta 2, a novel PP2C beta isoform, and to PP2C alpha. PP2C alpha and PP2C beta 2 co-purified with Mg(2+)-dependent Cdk2/Cdk6 phosphatase activity in DEAE-Sepharose, Superdex-200, and Mono Q chromatographies. Moreover, purified recombinant PP2C alpha and PP2C beta 2 proteins efficiently dephosphorylated monomeric Cdk2/Cdk6 in vitro. The dephosphorylation of Cdk2 and Cdk6 by PP2C isoforms was inhibited by the binding of cyclins. We found that the PP2C-like activity in HeLa cell extract, partially purified HeLa PP2C alpha and PP2C beta 2 isoforms, and the recombinant PP2Cs exhibited a comparable substrate preference for a phosphothreonine containing substrate, consistent with the conservation of threonine residues at the site of activating phosphorylation in CDKs.
Reactive navigation in outdoor environments using potential fields (2002)

The paper presents an approach to reactive navigation in cross-country terrains. The approach relies on a particular probabilistic obstacle detection procedure, that describes the area perceived by a pair of stereo cameras as a set of polygonal cells. To generate the motion commands on the basis of this terrain description, we present some improvements and adaptations to the classical potential fields technique. Results on real stereo data illustrate our contribution throughout the paper, and simulated long range traverses are discussed.
Separation and Purification of Organic Acids by Gas Antisolvent Crystallization (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeparation and Purification of Organic Acids by Gas Antisolvent CrystallizationAkihiro Shishikura, Kazuo Kanamori, Hideki Takahashi, and Hiroshi KinbaraCite this: J. Agric. Food Chem. 1994, 42, 9, 1993–1997Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/jf00045a030https://doi.org/10.1021/jf00045a030research-articleACS PublicationsRequest reuse permissionsArticle Views558Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A comprehensive review of protein kinase inhibitors for cancer therapy (2018)

Protein kinases are involved in various cellular functions. About 2% of the human genome encodes for protein kinases. Dysregulation of protein kinases is implicated in various processes of carcinogenesis. The advent of protein kinase inhibitors in cancer therapy has led to a paradigm shift in cancer therapy. Several protein kinase inhibitors have been approved by FDA in the last few decades. Areas covered: This article provides a review of the FDA approved protein kinase inhibitors as of December 2017 for the well-known oncogenic protein kinases. A list of FDA approved protein kinase inhibitors and their FDA approved clinical indications were cataloged. The role of the respective oncogenic protein kinases in carcinogenesis and cancer progression and the relevant landmark clinical trials of respective protein kinase inhibitors leading up to the FDA approval were PubMed searched and discussed. Expert commentary: Further understanding of the molecular origin of various cancers would help identify new targets. Use of biomarker profiling might select the patient population that would benefit better from kinase inhibitors. Clinical trials should be designed to identify the appropriate sequence of the available kinase inhibitors. It would prove to be useful to test these drugs in the adjuvant setting.
Enabling flexible cross-version interoperability for distributed services (1999)

Software evolution is one of the problematic areas in software management. In a distributed environment it is harder to tackle this problem because the dispersal of software makes it difficult to control the change, as well as the propagation of the change to whoever that is using the evolving service. The paper presents a model to alleviate this problem by making different distributed service versions substitutable. The mechanism comprises a mediator that enables clients of an old-version service to successfully request onto an instance of a new-version service. The mediator considers functionality compatibility, rather than operation signature compatibility, when mediating the request. Thus instead of forcing change on the client side, this model allows flexible interoperability between different versions of client and server software. To support the model, existing distributed object architectures may require some extension to their type repositories to maintain mapping information necessary for the work of the mediator.
Cardiac Segmentation from LGE MRI Using Deep Neural Network Incorporating Shape and Spatial Priors (2019)

Cardiac segmentation from late gadolinium enhancement MRI is an important task in clinics to identify and evaluate the infarction of myocardium. The automatic segmentation is however still challenging, due to the heterogeneous intensity distributions and indistinct boundaries in the images. In this paper, we propose a new method, based on deep neural networks (DNN), for fully automatic segmentation. The proposed network, referred to as SRSCN, comprises a shape reconstruction neural network (SRNN) and a spatial constraint network (SCN). SRNN aims to maintain a realistic shape of the resulting segmentation. It can be pre-trained by a set of label images, and then be embedded into a unified loss function as a regularization term. Hence, no manually designed feature is needed. Furthermore, SCN incorporates the spatial information of the 2D slices. It is formulated and trained with the segmentation network via the multi-task learning strategy. We evaluated the proposed method using 45 patients and compared with two state-of-the-art regularization schemes, i.e., the anatomically constraint neural network and the adversarial neural network. The results show that the proposed SRSCN outperformed the conventional schemes, and obtained a Dice score of 0.758(std=0.227) for myocardial segmentation, which compares with 0.757(std=0.083) from the inter-observer variations.
Flexible authentication in vehicular ad hoc networks (2009)

A Vehicular Ad-Hoc Network (VANET) is a form of Mobile ad-hoc network, to provide communications among nearby vehicles and between vehicles and nearby fixed roadside equipment. The key operation in VANETs is the broadcast of messages. Consequently, the vehicles need to make sure that the information has been sent by an authentic node in the network. VANETs present unique challenges such as high node mobility, real-time constraints, scalability, gradual deployment and privacy. No existent technique addresses all these requirements. In particular, both inter-vehicle and vehicle-to-roadside wireless communications present different characteristics that should be taken into account when defining node authentication services. That is exactly what is done in this paper, where the features of inter-vehicle and vehicle-to-roadside communications are analyzed to propose differentiated services for node authentication, according to privacy and efficiency needs.
Effect of a long‐term oral <scp>l</scp> ‐arginine supplementation on glucose metabolism: a randomized, double‐blind, placebo‐controlled trial (2012)

Among persons with IGT and MS, the supplementation of l-arg for 18 months does not significantly reduce the incidence of diabetes but does significantly increase regression to NGT.