gebhart/patrepeval huggingface dataset:
Rate Responsive Pacing Using the TX Pacemaker (1983)

We have evaluated clinically a rate-responsive pacemaker which uses the evoked QT principle as indicator of physiological demand. This pacemaker is microprocessor-based and fully programmable noninvasibly through radiofrequency coupling to an external microcomputer. To date this system has been implanted in 15 patients. With this QT sensing pacemaker the rate response to exercise was smooth and progressive, and gradually returned the basic paced rate after termination of activity. Physiological rate responsive pacing resulted in significant improvement in exercise tolerance and a 40% increase in cardiac output when compared to fixed-rate pacing in 8 patients. This initial experience confirms the possibility of obtaining a physiological response to exercise using a pacing system dependent only on a unipolar electrode which is independent of the problems of atrial activity and sensing. Rate responsive pacing might prove to be a useful alternative to atrial synchronous systems, particularly advantageous in those patients whose sinoatrial function is abnormal or who suffer from atrial arrhythmias.
Who will dominate HMO master contracting? (1995)

Physicians, hospitals, and payers are all forming networks that will be capable of performing the spectrum of health care services and taking the financial risk for these services. These networks will ultimately compete for the HMO master contracts to provide these services and control more of the premium dollar. Physician groups and hospitals have different strengths with respect to forming effective networks. Physicians have the advantage in establishing IPA-model networks, while hospitals have an advantage in staff-model networks.
Mild or Moderate Covid-19 (2020)

Key Clinical Points Mild or Moderate Covid-19 Covid-19 (the illness caused by SARS-CoV-2) has a range of clinical manifestations, including cough, fever, malaise, myalgias, gastrointestinal symptom...
High Susceptibility for Cystic Fibrosis Human Airway Gland Cells to Produce IL-8 Through the IκB Kinase α Pathway in Response to Extracellular NaCl Content (2000)

Increasing evidence suggests that in airways from cystic fibrosis (CF) patients, inflammation may precede bacterial infection and be related to an endogenous dysregulation of proinflammatory cytokines in airway epithelial cells. Several investigators have reported that, in CF airway fluids, elevated NaCl concentrations may also contribute to the diseased state by inhibiting the bactericidal properties of airway fluid. Because many proinflammatory cytokines are transcriptionally regulated by the NF-kappa B, we investigated whether an elevated extracellular NaCl content in airway fluids significantly impaired the regulation of the NF-kappa B/I kappa B alpha complex and the chemokine IL-8 production in primary non-CF and CF human bronchial gland epithelial cells. Exposure of non-CF gland cells to hypotonic (85 mM) NaCl solution, compared with isotonic (115 mM) NaCl and hypertonic (170 mM) NaCl solutions, resulted in a significant decrease in IL-8 production that was paralleled by a strong inhibition of activated NF-kappa B associated with an increased cytosolic expression of I kappa B alpha and a decrease in the I kappa B kinase alpha protein level. In CF gland cells, we demonstrated that, compared with the high IL-8 in an hypertonic solution, the release of IL-8 was significantly reduced 2-fold in an isotonic solution and 5-fold in a hypotonic solution. Strikingly, exposure of CF bronchial gland cells to either hypotonic or isotonic milieu did not result in a marked inhibition of the activated NF-kappa B/I kappa B alpha system. This is the first demonstration that primary human CF bronchial gland cells exhibit abnormally high IL-8 production through constitutively activated NF-kappa B and high I kappa B kinase alpha level, whatever the hypo-, iso-, and hypertonic NaCl milieu.
Performing quantum computing experiments in the cloud (2016)

Quantum computing technology has reached a second renaissance in the past five years. Increased interest from both the private and public sector combined with extraordinary theoretical and experimental progress has solidified this technology as a major advancement in the 21st century. As anticipated my many, some of the first realizations of quantum computing technology has occured over the cloud, with users logging onto dedicated hardware over the classical internet. Recently, IBM has released the Quantum Experience, which allows users to access a five-qubit quantum processor. In this paper we take advantage of this online availability of actual quantum hardware and present four quantum information experiments. We utilize the IBM chip to realize protocols in quantum error correction, quantum arithmetic, quantum graph theory, and fault-tolerant quantum computation by accessing the device remotely through the cloud. While the results are subject to significant noise, the correct results are returned from the chip. This demonstrates the power of experimental groups opening up their technology to a wider audience and will hopefully allow for the next stage of development in quantum information technology.
Micro-Wilhelmy and Related Liquid Property Measurements Using Constant-Diameter Nanoneedle-Tipped Atomic Force Microscope Probes (2008)

The micro-Wilhelmy method is a well-established method of determining surface tension by measuring the force of withdrawing a tens of microns to millimeters in diameter cylindrical wire or fiber from a liquid. A comparison of insertion force to retraction force can also be used to determine the contact angle with the fiber. Given the limited availability of atomic force microscope (AFM) probes that have long constant diameter tips, force-distance (F-D) curves using probes with standard tapered tips have been difficult to relate to surface tension. In this report, constant diameter metal alloy nanowires (referred to as "nanoneedles") between 7.2 and 67 microm in length and 108 and 1006 nm in diameter were grown on AFM probes. F-D and Q damping AFM measurements of wetting and drag forces made with the probes were compared against standard macroscopic models of these forces on slender cylinders to estimate surface tension, contact angle, meniscus height, evaporation rate, and viscosity. The surface tensions for several low molecular weight liquids that were measured with these probes were between -4.2% and +8.3% of standard reported values. Also, the F-D curves show well-defined stair-step events on insertion and retraction from partial wetting liquids, compared to the continuously growing attractive force of standard tapered AFM probe tips. In the AFM used, the stair-step feature in F-D curves was repeatably monitored for at least 0.5 h (depending on the volatility of the liquid), and this feature was then used to evaluate evaporation rates (as low as 0.30 nm/s) through changes in the surface height of the liquid. A nanoneedle with a step change in diameter at a known distance from its end produced two steps in the F-D curve from which the meniscus height was determined. The step features enable meniscus height to be determined from distance between the steps, as an alternative to calculating the height corresponding to the AFM measured values of surface tension and contact angle. All but one of the eight measurements agreed to within 13%. The constant diameter of the nanoneedle also is used to relate viscous damping of the vibrating cantilever to a macroscopic model of Stokes drag on a long cylinder. Expected increases in drag force with insertion depth and viscosity are observed for several glycerol-water solutions. However, an additional damping term (associated with drag of the meniscus on the sidewalls of the nanoneedle) limits the sensitivity of the measurement of drag force for low-viscosity solutions, while low values of Q limit the sensitivity for high-viscosity solutions. Overall, reasonable correspondence is found between the macroscopic models and the measurements with the nanoneedle-tipped probes. Tighter environmental control of the AFM and treatments of needles to give them more ideal surfaces are expected to improve repeatability and make more evident subtle features that currently appear to be present on the F-D and Q damping curves.
Yeast TKL1 gene encodes a transketolase that is required for efficient glycolysis and biosynthesis of aromatic amino acids. (1993)

A gene encoding transketolase, TKL1, was cloned from the budding yeast Saccharomyces cerevisiae using oligonucleotide primers derived from protein sequence data. The TKL1 sequence predicts a 74-kDa polypeptide which is related to other transketolases. A sequence comparison revealed that the transketolases can be subdivided into three evolutionary branches. We also found that the transketolases are related to another vitamin B1-dependent enzyme: the E1 subunit of pyruvate dehydrogenase from Escherichia coli. Gene disruption and overexpression experiments were used to investigate the function of transketolase in yeast. We found that growth on fermentable carbon sources, but not on gluconeogenic carbon sources, is reduced in cells disrupted for TKL1. This suggests that the glycolytic efficiency is impaired. Growth on fermentable carbon sources is also reduced in cells that overexpress TKL1. Finally, we found that cells disrupted for TKL1 are unable to grow in the absence of aromatic amino acids. This is most likely due to the fact that transketolase is required for the synthesis of erythrose-4-P, a precursor of the aromatic amino acids.
(Invited) Properties and Applications of 2-Dimensional Layered Materials (2016)

Two-dimensional transition metal dichalcogenides (TMDs) have moved to the foreground of the research community owing to their fascinating properties which make them of great interest for both fundamental studies and emerging applications. Thermally assisted conversion (TAC) of predeposited transition metal films and Chemical vapour deposition (CVD) show great promise for the scalable and industry-compatible synthesis of these materials [1] . Here we outline the production of an assortment of TMDs by TAC and CVD, and demonstrate their high-quality using an array of characterization techniques including Raman spectroscopy, X-ray photoelectron spectroscopy and transmission electron microscopy. The potential of TMDs films for various applications in the realm of electronics and energy will be discussed. It is possible to structure and electrically address the films yielding simple devices such as transistors, diodes and sensors. The fabrication of high-performance gas sensors, with room temperature detection limits in the ppb range for NH 3 will be described in detail [2] . The fabrication of large-scale heterojunction diodes, formed by transferring n-type MoS 2 onto p-type Si, will be outlined. [3] Additionally, a novel catalyst platform for the hydrogen evolution reaction (HER), consisting of MoS 2 (or other TMDs) grown directly on top of a carbon electrode, will be discussed [4] . [1] "Controlled Synthesis of Transition Metal Dichalcogenide Thin Films for Electronic Applications" , Riley Gatensby, Niall McEvoy, Kangho Lee, Toby Hallam, Nina C. Berner, Ehsan Rezvani, Sinéad Winters, Maria O'Brien, Georg S. Duesberg, Applied Surface Science, 297, 139-146, (2014) [2] "High Performance Sensors Based on Molybdenum Disulfide Thin Films" , Kangho Lee, Riley Gatensby, Niall McEvoy, Toby Hallam, Georg S. Duesberg, Advanced Materials, 25(46), 6699-6702, (2013) [3] "Heterojunction Hybrid Devices from Vapor Phase Grown MoS 2 " , Chanyoung Yim, Maria O'Brien, Niall McEvoy, Sarah Riazimehr, Heiko Schäfer-Eberwein, Andreas Bablich, Ravinder Pawar, Giuseppe Iannaccone, Clive Downing, Gianluca Fiori, Max C. Lemme & Georg S. Duesberg, Scientific Reports, 4, 5458, (2014) [4] "Molybdenum disulfide/pyrolytic carbon hybrid electrodes for scalable hydrogen evolution", Hugo Nolan, Niall McEvoy, Maria O'Brien, Nina C. Berner, Chanyoung Yim, Toby Hallam, Aidan R. McDonald and Georg S. Duesberg, Nanoscale, 6, 8185-8191, (2014)
Profile of Commitment- Howard Fenimore Shipps (1973)

My call to teach at Asbury
Con nombre propio (2001)

En ocasiones la identificacion de una marca con un producto impide que la empresa saque al mercado un producto de otro sector manteniendo la misma marca. Asi que hay que mantenerse a la altura de las expectativas que crea el nombre de marca para iniciar una nueva categoria de producto. Para expandirse es necesario comprender los valores que vende la marca, de esta forma se evitan productos inadecuados. O sea, si la marca tiene atribuidas cualidades como la precision y la calidad, la expansion debe ir en esa direccion
Humidity Effect on Nanoscale Electrochemistry in Solid Silver Ion Conductors and the Dual Nature of Its Locality (2015)

Scanning probe microscopy (SPM) is a powerful tool to investigate electrochemistry in nanoscale volumes. While most SPM-based studies have focused on reactions at the tip-surface junction, charge and mass conservation requires coupled and intrinsically nonlocal cathodic and anodic processes that can be significantly affected by ambient humidity. Here, we explore the role of water in both cathodic and anodic processes, associated charge transport, and topographic volume changes depending on the polarity of tip bias. The first-order reversal curve current-voltage technique combined with simultaneous detection of the sample topography, referred to as FORC-IVz, was applied to a silver solid ion conductor. We found that the protons generated from water affect silver ionic conduction, silver particle formation and dissolution, and mechanical integrity of the material. This work highlights the dual nature (simultaneously local and nonlocal) of electrochemical SPM studies, which should be considered for comprehensive understanding of nanoscale electrochemistry.
Reaktionen von Pentacarbonyl(trifluormethylisocyanid)chrom mit Nucleophilen (1990)

Reactions of Pentacarbonyl(trifluoromethyl isocyanide)chromium with Nucleophiles Pentacarbonyl(trifluoromethyl isocyanide)chromium ( 1 ) reacts with nucleophilic reagents like secondary amines ( 2a‐d ), 1,2‐dimethylhydrazine ( 2e ), or methanol ( 2f ). The first nucleophilic attack occurs at the isocyanide carbon atom. The formed Fischer‐type carbene complexes readily eliminate HF under the reaction conditions forming a difluoromethanimine moiety, which is further attacked by the nucleophile. The isolated products are carbene complexes of the type (CO) 5 Cr[C(NR 2 ]N=C(NR 2 )F] ( 3a‐c ), (CO) 5 Cr[C(NR 2 )N=C(NR 2 ) 2 ]( 3d ), (CO) 5 Cr[CN(CH 3 )N(CH) 3 C{N(CH 3 )H}=N] ( 3e ), and (CO) 5 Cr(C(OCH 3 )N=C(OCH 3 ) 2 ] ( 3f ). The structure of 3c has been determined by an X‐ray crystal structure analysis.
A Novel Specific Small Molecule Peptide for Non-small Cell Lung Cancer Cell A549 (2007)

To screen small molecule peptide specific binding to non-small cell lung cancer cell (A549) using the one-bead one-peptide combinatorial library. Twenty-nine positive beads binding to A549 cell were totally obtained after primary screening. Consensus peptide sequence of -NGXG-was identified by amino acid sequencing in ten beads. Peptide cNGQGEQc was re-synthesized on beads and further studied for its cell specificity, alanine scanning and site-directed deletion. The results showed that cNGQGEQc is specific for cell attachment to non-small cell lung cancer cells including A549, Calu-1 and H178, but not to other tumor cell lines. Both motif of -NGXG-and the length of six peptides are very important for A549 adhesion. Peptide cNGQGEQc labeled with FITC can specifically bind to A549 cell. In a blocking assay with anti-integrin antibodies(α1～6, αv/β1～5), cell adhesion of A549 to peptide beads was obviously inhibited by integrin α3 combining with any β subunits. Results suggested that small molecule peptide cNGQGEQc can bind specifically to non-small cell lung cancer cell A549 via integrin α3 on cell surface.
[Arteriosclerosis and blood lipids]. (1989)

In our examinations of the new-born and their parents, of the patients with coronary heart disease and their relations, of the healthy test persons of different age and of the families of the long-lived persons we have found that in the atherogenesis genetic factors and blood lipids play a great part. In future it is perhaps possible already early to recognize in children a genetically conditioned hyperlipoproteinaemia, all the more since in the patients with hereditary load was to be observed a clear increase of the indices of lipid metabolism in comparison to the healthy test persons. Furthermore, a connection between a hyperlipoproteinaemia and the AB0 blood groups was stated. A combination of the hyperlipoproteinaemia of type IIb with the blood group A in new-born and in patients after myocardial infarction belongs to the most important risk factors for the atherogenesis. On account of these findings it is possible to establish a hyperlipoproteinaemia in childhood in children with hereditary load, which gives the possibility by means of normalization of the lipids to perform an early prophylaxis of the arteriosclerosis. The examination of the long-lived persons showed that the arteriosclerosis is not certainly an accompanying appearance of old age, for the autopsies of persons 100 years of age and more did not show any arteriosclerotic changes of the vessels.
Rapid Fabrication of Flexible and Stretchable Strain Sensor by Chitosan‐Based Water Ink for Plants Growth Monitoring (2017)

Rapid fabrication of flexible and stretchable sensors is essential for the emerging applications of wearable devices. In this study, a chitosan‐based water ink realizes fabrication of flexible and stretchable stain sensor by simply writing the ink and leaving it to dry for ≈15 min at room temperature. It is found that chitosan is an excellent binding material. The fabricated sensor shows an excellent gauge factor of 64 within strain 1%–8%, and can be stretched up to 60%. More importantly, the sensor can be directly written on the subject, and sensors written on plants show that plants can response to mechanical injuries within a few minutes. These results show that this method reduces the energy and time consumption in the fabrication procedure, realizes direct fabrication of sensors on subjects for wearable monitoring, and meets the requirements for personalized and on‐site applications. So, this chitosan‐based ink provides an attractive strategy for the fabrication and application of wearable devices.
A 3D printed patient-specific dual compartment breast phantom for validating MRI acquisition and analysis techniques (2019)

Anthropomorphic phantoms are essential tools that are used to validate MRI acquisition and analysis techniques. 3D printing technologies are rapidly advancing and can be utilized to achieve anatomically realistic geometries that are not attainable using traditional manufacturing methods. Herein, we present the design of a 3D printed anthropomorphic breast phantom that includes the key breast tissue compartments which are filled with desired tissue-mimicking fluids. The breast phantom can be used for validating MR, coil development, safety evaluation and pulse sequence evaluation.
Simulation of Shale Gas Flow in Nano Pores with Parallel Lattice Boltzmann Method (2015)

Summary Due to the complex pore structures with a large portion of nano pores, flow mechanics of shale gas in organic-rich shale kerogen pores may involve in some nanoscale effects that could not be accounted for by classic Darcy’s law. In this study, we present a parallel lattice Boltzmann method (PLBM) to study these effects and to simulate 3D flow process of natural gas in real pore geometry of a shale reservoir rock. The numerical advantages of LBM make it a powerful tool to simulate gas flow in such nano pores. The new parallel implementation with standard Message Passing Interface (MPI) communication routines has been well tested. By simulating the flow process of shale gas in a tube model and real geometry of shale core through PLBM on high performance computing cluster, the results show that many factors (such as rarefaction effect, slippage effect and roughness effect, etc.) have a great impact on the flow process of shale gas in nano pores and LBM is an effective way to simulate shale gas flow in kerogen pores, and compared to other physical experimental methods, it has great convenience and accuracy.
A systematic approach to standard addition methods in instrumental analysis (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA systematic approach to standard addition methods in instrumental analysisMorris Bader Cite this: J. Chem. Educ. 1980, 57, 10, 703Publication Date (Print):October 1, 1980Publication History Received3 August 2009Published online1 October 1980Published inissue 1 October 1980https://doi.org/10.1021/ed057p703RIGHTS & PERMISSIONSArticle Views3451Altmetric-Citations199LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Smoking Out Big Tobacco: Some Lessons About Academic Freedom, The World Wide Web, Media Conglomeration, and Public Service Pedagogy from the Battle Over the Brown & Williamson Documents (1997)

1-Oxoalkyl and 1,2-dioxoalkyl-1,2,4-triazolidine-3,5-diones proved to be potent antineoplastic agents in mouse tumors and potent cytotoxic agents particularly against the growth of suspended tumor cells. The compounds with shorter substituents in position 1 or positions 1 and 2 afforded the better activity. In L1210 lymphoid leukemia cells DNA, RNA, and protein syntheses were inhibited at 100 microM after 60 min. Multiple enzyme sites in nucleic acid metabolism were affected by the compounds, i.e. DNA polymerase alpha, PRPP-amido transferase, dihydrofolate reductase, thymidylate synthetase, and nucleoside kinases. These effects of the agents are probably additive in bringing about inhibition of DNA synthesis and cell death.
Electronic and Optical Properties of ${\rm a}$- and ${\rm m}$-Plane Wurtzite InGaN–GaN Quantum Wells (2007)

Electronic and optical properties of a-(∅=0) and 𝔪-plane(∅-π /6) InGaN-GaN quantum-well (QW) structures are investigated using the multiband effective-mass theory with an arbitrary crystal orientation. These results are compared with those of 𝔠-plane or (0001)-oriented wurtzite InGaN-GaN QWs. We derive explicitly the Hamiltonians with their elements and the interband optical matrix elements with polarization dependence for the 𝔞-, 𝔪-, and 𝔠-planes. The bandgap transition wavelen𝔞 -plane. The average hole effective masses of the topmost valence band along 𝑘'ᵧ for the 𝔞- and 𝔪-planes are significantly lower than that of the 𝔠-plane. Here, the prime indicates physical quantities in a general crystal orientation. In addition, their optical gain and optical matrix element show strong in-plane anisotropy. The optical gain of the 𝑦'-polarization is much larger than that of the 𝓍' -polarization because the optical matrix element for the 𝑦'-polarization is larger than that of the 𝓍'-polarization.