gebhart/patrepeval huggingface dataset:
Diseño experimental de estructuras laminares (1971)

Esencialmente la técnica de diseño propuesta consiste en obtener la forma del modelo f-y de la estructura, consecuentemente— por las posiciones que toman los nudos de una retícula de hilos de goma sometida a la acción de las cargas. fe Simultáneamente con la forma se puede reconocer el plexo tensional: midiendo la longitud de cada lado de la retícula y la fuerza que lo solicita (alargamiento del hilo de goma) es posible obtener, en forma aproximada, las direcciones y esfuerzos principales. Toda modificación en la forma produce modificación en los lados (longitudes y alargamientos) de la retícula, o sea, todo cambio en la geometría tiene una respuesta en términos de fuerzas. Como verificación, se aplica la técnica propuesta —que denominamos «retícula elástica»— a una cúpula esférica. Se analizan las limitaciones y posibilidades de dicha técnica.
A Schema for Constraint Relaxation with Instantiations for Partial Constraint Satisfaction and Schedule Optimization (1994)

We investigate constraint relaxation within a general constraint model. We claim that a key to relaxation is recognition that a constraint can be modified in a variety of ways and that each modification potentially carries a different impact for both the quality of the solution and the problem solving process. Our primary motivation is the application of constraint relaxation as a technique for coordination of multiple agents in a shared environment. We propose a schema for constraint relaxation that is based on the propagation of information through a constraint graph. The schema isolates five heuristic decision points where techniques of varying complexities can be specified. Three algorithms within the schema are declared and shown to perform well on Partial Constraint Satisfaction Problems (PCSPs). Three additional algorithms are defined and used in the estimation of the impact of scheduling decisions in a medium size job shop scheduling problems. Difficulties with the calculation of actual impact data prevents comparison among the algorithms. The algorithms represent an advance by allowing propagation over all types of constraints and the ability to integrate heuristic decision making. iii ivAcknowledgments
Physical-property data on fluorinated propanes and butanes as CFC and HCFc alternatives. Rept. for Aug 88-Jun 91 (1992)

The paper discusses results of the measurement and estimation of the physical properties of fluorinated propane derivatives as second generation alternatives for currently used CFC and HCFC chemicals. One fluorinated ether was also studied. A total of 22 compounds were investigated with boiling points of -34.6 to 76.7 C. The measured properties presented for these compounds are: melting point, boiling point, vapor pressure below the boiling point, heat of vaporization, critical properties (temperature, density, and pressure), liquid densities, and liquid-phase heat capacities. Measured vapor pressures are reported from below the boiling point to the critical point for two of these compounds: CF3OCF2H (b.p. = 34.6 C and Tc = 80.7 C) and CF3CHFCF2H (b.p. = 6.5 C and Tc = 141.1 C). Vapor pressures and liquid-phase densities were also measured for CFC-12 in order to judge the accuracy of the experimental methods used. The measured vapor pressures were also compared with vapor pressures estimated using modified corresponding states methods to evaluate the accuracy of the estimation methods.
Ecstasy pill testing: harm minimization gone too far? (2001)

Harm reduction has become the focus of public health initiatives and therapeutic intervention in the management of dependent drug use over the last 20 years. The last decade has seen such approaches being extended to recreational drug use. Most harm reduction initiatives have aimed to inform users about risks and ways of minimizing risk. The concept of providing illicit drug users with quality assessment of their chosen drug is one possible harm reduction intervention that until recently has received little attention. In response to well-publicized 'ecstasy'-related deaths organizations in some European countries and the United States have chosen to provide a 'pill testing service' for users. There are two broad categories of pill testing offered. Simple colour reagent test kits (Marquis Reagent and colour charts) form the most widely used on-site pill testing method. Less frequently, but more accurately, laboratory personnel with access to sophisticated chromatographic equipment (high performance liquid chromatography (HPLC) or gas chromatography-mass spectrometry (GC-MS)) may provide analysis of a pill. Pill testing kits have been advocated as a 'tool to protect yourself against the polluted XTC market'. We refute this line of reasoning. Of the different tests only techniques such as GC-MS can identify satisfactorily the psychoactive constituents present in ecstasy pills. Colour tests based on an interpretation of a colour response in the presence of a drug are, at best, subjective. Pill testing of any description does not guarantee safety, or protect the consumer against individual responses to pills. At best it gives an artificial 'shine of safety' to a group of diverse drugs that remain both illicit and potentially harmful. Other simpler harm reduction mechanisms are likely to be more effective.
Cdc42 Promotes Host Defenses against Fatal Infection (2013)

The small Rho GTPase Cdc42 regulates key signaling pathways required for multiple cell functions, including maintenance of shape, polarity, proliferation, invasion, migration, differentiation, and morphogenesis. As the role of Cdc42-dependent signaling in fibroblasts in vivo is unknown, we attempted to specifically delete it in these cells by crossing the Cdc42(fl/fl) mouse with an fibroblast-specific protein 1 (FSP1)-Cre mouse, which is thought to mediate recombination exclusively in fibroblasts. Surprisingly, the FSP1-Cre;Cdc42(fl/fl) mice died at 3 weeks of age due to overwhelming suppurative upper airway infections that were associated with neutrophilia and lymphopenia. Even though major aberrations in lymphoid tissue development were present in the mice, the principal cause of death was severe migration and killing abnormalities of the neutrophil population resulting in an inability to control infection. We also show that in addition to fibroblasts, FSP1-Cre deleted Cdc42 very efficiently in all leukocytes. Thus, by using this nonspecific Cre mouse, we inadvertently demonstrated the importance of Cdc42 in host protection from lethal infections and suggest a critical role for this small GTPase in innate immunity.
Preparation of a monoclonal antibody specific for the class IV isotype of beta-tubulin. Purification and assembly of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers from bovine brain. (1992)

Tubulin, the 100-kDa subunit protein of microtubules, is a heterodimer of two 50-kDa subunits, alpha and beta. Both alpha and beta subunits exist as numerous isotypic forms. There are four isotypes of beta-tubulin in bovine brain tubulin preparations; their designations and relative abundances in these preparations are as follows: beta I, 3%; beta II, 58%; beta III, 25%; and beta IV, 13%. We have previously reported the preparation of monoclonal antibodies specific for beta II and beta III (Banerjee, A., Roach, M. C., Wall, K. A., Lopata, M. A., Cleveland, D. W., and Luduena, R. F. (1988) J. Biol. Chem. 263, 3029-3034; Banerjee, A., Roach, M. C., Trcka, P., and Luduena, R. F. (1990) J. Biol. Chem. 265, 1794-1799). We here report the preparation of a monoclonal antibody specific for beta IV. By using this antibody together with those specific for beta II and beta III, we have prepared isotypically pure tubulin dimers with the composition alpha beta II, alpha beta III, and alpha beta IV. We have found that, in the presence of microtubule-associated proteins, all three dimers assemble into microtubules considerably faster and to a greater extent than does unfractionated tubulin. More assembly was noted with alpha beta II and alpha beta III than with alpha beta IV. When assembly is measured in the presence of taxol (10 microM), little difference is seen among the isotypically purified dimers or between them and unfractionated tubulin. These results indicate that the assembly properties of a tubulin preparation are influenced by its isotypic composition and raise the possibility that the structural differences among tubulin isotypes may have functional significance.
Penguin: Objects for Programs, Relations for Persistence (1999)

This article introduces complementarity theory, which explains the psychology of cultural diversity as a product of evolved social proclivities that enable-and require-people to coordinate action in culture-specific ways. The theory presents evolutionary processes and psychological mechanisms that may account for the cultural variability of social coordination devices such as language, relational models, rituals, moral interpretations of misfortune, taboos, religion, marriage, and descent systems. Human fitness and well-being depend on social coordination characterized by complementarity among the participants' actions. This complementarity is based primarily on coordination devices derived from the conjunction of cultural paradigms and specific, highly structured, evolved proclivities. The proclivities have no adaptive value without the paradigms, and the paradigms have no meaning without the proclivities. They are coadapted to function together. Operating in conjunction with each other, proclivities and paradigms jointly define the generative structures for meaningful coordination of social interaction in each particular culture.
Effect of Visible and UV Illumination on the Water Contact Angle of TiO<sub>2</sub> Thin Films with Incorporated Nitrogen (2007)

Doping TiO2 with nitrogen is recognized as a procedure to get sensitization of this material with visible light. In the present work, incorporation of nitrogen within the structure of TiO2 thin films has been accomplished by N2+ ion implantation in TiO2 anatase thin films (50 keV ion energy for doses of 3 × 1016, 6 × 1016, and 1.2 × 1017 ions cm-2) and during preparation by metalorganic chemical vapor deposition (MOCVD) using nitrogen as carrier gas. The analysis of the samples by X-ray photoemission spectroscopy (XPS) and for the MOCVD samples also by secondary ion mass spectroscopy (SIMS) has shown that nitrogen, in the form of nitride-like species, (N/Ti ratios of 0.03 and 0.12 for the MOCVD and the implanted samples, respectively) has become effectively incorporated within the structure of TiO2. The water contact angle on the implanted thin films varied from about 80° to around 30° when illuminated with visible light, depending on the ion dose. Similarly, the MOCVD samples showed a sharp decrease in wetting contact angle under visible light from about 80° to 55°. In the two cases, the thin films reach total hydrophilicity by posterior UV irradiation. To account for these results, the possible existence of specific excitation mechanisms for visible or UV photons, the former involving the incorporated nitrogen atoms, is discussed.
Design of prefilters for discrete multiwavelet transforms (1996)

The pyramid algorithm for computing single wavelet transform coefficients is well known. The pyramid algorithm can be implemented by using tree-structured multirate filter banks. The authors propose a general algorithm to compute multiwavelet transform coefficients by adding proper premultirate filter banks before the vector filter banks that generate multiwavelets. The proposed algorithm can be thought of as a discrete vector-valued wavelet transform for certain discrete-time vector-valued signals. The proposed algorithm can be also thought of as a discrete multiwavelet transform for discrete-time signals. The authors then present some numerical experiments to illustrate the performance of the algorithm, which indicates that the energy compaction for discrete multiwavelet transforms may be better than the one for conventional discrete wavelet transforms.
Spatial interference management with hierarchical precoding in ultra-dense heterogeneous networks (2015)

In this work we focus on ultra-dense heterogeneous networks which are one of the key-concepts to increase the spectral efficiency for future mobile networks. Therefore, macro and small cells are operating on the same frequencies to increase the reuse of the spectrum. With this, interference caused by the macro toward users attached to the small cells becomes the limiting performance factor. Aiming for ultra-dense networks with many small cells, also interference from the small-cells to macro-attached, and other small-cell users has an impact which cannot be neglected. To cope with this challenge we use a novel two-stage hierarchical precoding/beamforming approach to protect small-cell users from macro-interference, while still serving macro-users at the same time. In doing so, Channel State Information (CSI) at the transmitter (CSIT) between the macro and small-cell users is required at the macro cell. We adapted an iterative Interference Alignment (IA) algorithm operating in the common null space of the macro-users to ensure interference decoupling of macro and small cell users. All the processing is done at the macro Base Station (BS) allowing independent transmission of the small-cells. This means no further feedback, information (e.g. precoder) or user data exchange between transmit nodes is required.
Changing Models for Commercialization and Implementation of Biocontrol in the Developing and the Developed World (2010)

Photodynamic therapy (PDT) is a non-invasive, selective, and cost-effective cancer therapy. The development of readily accessible templates that allow rapid structural modification for further improvement of PDT remains important. We previously reported thiophene-based organic D-π-A sensitizers consisted of an electron-donating (D) moiety, a π-conjugated bridge (π) moiety, and an electron-accepting (A) moiety as valuable templates for a photosensitizer that can be used in PDT. Our preliminary structure-activity relationship study revealed that the structure of the A moiety significantly influences its phototoxicity. In this study, we evaluated the photoabsorptive, cellular uptake, and photo-oxidizing abilities of D-π-A sensitizers that contained different A moieties. The level of phototoxicity of the D-π-A sensitizers was rationalized by considering those three abilities. In addition, we observed the ability of amphiphilic sensitizers containing either a carboxylic acid or an amide in an A moiety to form aggregates that penetrate cells mainly via endocytosis.
Genetic Breeding of<scp>l</scp>-Tyrosine Producer from<i>Bvevihactevium lactofermentum</i> (1990)

A wild-type parent of Brevibacterium lactofermentum was converted into an L-Tyr producer by three steps of genetic breeding. First, acquirement of m-fluoro-D, L-phenylalanine resistance (1,000 microgram/ml) brought about MF1317 which produced 3.5 g/l of L-Tyr and a byproduct of 2.8 g/l of L-Phe. Second, increase in the drug resistance (5,000 microgram/ml) gave MF358 that produced 6.4 g/l of L-Tyr and a byproduct of 6.0 g/l of L-Phe. Third, an L-Phe auxotrophic mutant (FT-1) derived from MF358 accumulated 16 g/l of L-Tyr. In FT-1, L-Phe was not accumulated at all, but a small amount of anthranilate (0.4 g/l) was. A key enzyme in the biosynthesis of L-Tyr, 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, was free from synergistic feedback inhibition by L-Tyr and L-Phe in the producers, and so L-Tyr accumulation occurred independently of L-Phe concentration in the production medium.
Identification of Novel Human Adipocyte Secreted Proteins by Using SGBS Cells (2010)

Adipose tissue is an endocrine organ secreting different types of proteins, known as adipokines. These adipokines play important roles in homeostasis and metabolism. Adipocyte differentiation leads to a change in adipokine secretion profile which is probably involved in disruption of homeostasis. Many adipokines have been identified but species differences and limitations of human adipose tissue material urged the need for better model systems. Here we used a human cell strain derived from a Simpson Golabi Behmel syndrome (SGBS) patient. SGBS cells have already been used in functional studies on adipocytes but not in a proteomic search for adipokines. In this study, 2D-MS/MS and nLC-MALDI-MS/MS were applied to investigate secretion profiles of SGBS adipokines. A total of 80 secreted proteins were identified; 6 proteins are novel adipocyte secreted proteins, 20 proteins have not been detected before in human adipose material and 23 additional proteins previously detected in visceral adipose tissue have been found here secreted by SGBS-cells of subcutaneous origin. It can be concluded that SGBS cells are both a valid human cell model for adipocyte secretion profiling and for searching for novel human (pre)adipocytes secreted proteins.
Catalytic activity of anin vivo tumor targeted anti-CEA scFv::carboxypeptidase G2 fusion protein (2000)

Antibody-directed enzyme prodrug therapy (ADEPT) targets an enzyme selectively to a tumor where it converts a relatively non-toxic prodrug to a potent cytotoxic drug. Previous clinical work using antibody-enzyme chemical conjugates has been limited by the moderate efficiency of tumor targeting of these molecules. To address this a recombinant fusion protein composed of MFE-23, an anti-carcinoembryonic antigen (CEA) single chain Fv (scFv) antibody, fused to the amino-terminus of the enzyme carboxypeptidase G2 (CPG2) has been constructed to achieve ADEPT in CEA-producing tumors. MFE-23::CPG2 fusion protein was overexpressed in Escherichia coli and purified using CEA affinity chromatography. Efficacy of MFE-23::CPG2 delivery to tumors in vivo was assessed by measuring catalytic activity after intravenous injection of purified MFE-23::CPG2 into nude mice bearing CEA-positive LS174T human colon adenocarcinoma xenografts. Recombinant MFE-23::CPG2 cleared rapidly from circulation and catalytic activity in extracted tissues showed tumor to plasma ratios of 1.5:1 (6 hr), 10:1 (24 hr), 19:1 (48 hr) and 12:1 (72 hr). (125)I-MFE-23::CPG2 was retained in kidney, liver and spleen but MFE-23::CPG2 catalytic activity was not, resulting in excellent tumor to normal tissue enzyme ratios 48 hr after injection. These were 371:1 (tumor to liver), 450:1 (tumor to lung), 562:1 (tumor to kidney), 1,477:1 (tumor to colon) and 1,618:1 (tumor to spleen). Favorable tumor : normal tissue ratios occurred at early time points when there was still 21% (24 hr) and 9.5% (48 hr) of the injected activity present per gram of tumor tissue. The high tumor concentrations and selective tumor retention of active enzyme delivered by MFE-23::CPG2 establish that this recombinant fusion protein has potential to give improved clinical efficiency for ADEPT.
Kinetic Measurement and Real Time Visualization of Somatic Reprogramming (2016)

Somatic reprogramming has enabled the conversion of adult cells to induced pluripotent stem cells (iPSC) from diverse genetic backgrounds and disease phenotypes. Recent advances have identified more efficient and safe methods for introduction of reprogramming factors. However, there are few tools to monitor and track the progression of reprogramming. Current methods for monitoring reprogramming rely on the qualitative inspection of morphology or staining with stem cell-specific dyes and antibodies. Tools to dissect the progression of iPSC generation can help better understand the process under different conditions from diverse cell sources. This study presents key approaches for kinetic measurement of reprogramming progression using flow cytometry as well as real-time monitoring via imaging. To measure the kinetics of reprogramming, flow analysis was performed at discrete time points using antibodies against positive and negative pluripotent stem cell markers. The combination of real-time visualization and flow analysis enables the quantitative study of reprogramming at different stages and provides a more accurate comparison of different systems and methods. Real-time, image-based analysis was used for the continuous monitoring of fibroblasts as they are reprogrammed in a feeder-free medium system. The kinetics of colony formation was measured based on confluence in the phase contrast or fluorescence channels after staining with live alkaline phosphatase dye or antibodies against SSEA4 or TRA-1-60. The results indicated that measurement of confluence provides semi-quantitative metrics to monitor the progression of reprogramming.
Theory and Design of $N$-Push BJT Clamping Harmonic Generator for Silicon Terahertz ICs (2012)

We present a <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$N$</tex> </formula> -push BJT clamping harmonic generator and an optimal operation condition is derived to maximize the desired <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$N ^{th}$</tex></formula> harmonic component. Under the hard switching condition, harmonic currents are calculated from time domain waveform generated from a simplified BJT model. Output waveform and the harmonic currents match well with Harmonic Balance (HB) simulation. For verification, measurements from a 380 GHz quadrupler with the on-chip patch antenna implemented in 0.13 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu{\rm m}$</tex></formula> SiGe BiCMOS are presented. Optimal biasing point for maximum EIRP corresponds well with the calculated value.
A variably trimmed mean CFAR radar detector (1992)

A variably trimmed mean (VTM) constant false alarm rate (CFAR) detector in which the threshold is determined by processing a linear combination of a group of ordered samples in each window is introduced. Unlike the trimmed mean detector, the number of ordered samples that require further processing is allowed to vary according to a data-dependent rule. It is demonstrated that the VTM detector exhibits performance characteristics that are independent of the total (stationary) noise power. Simulated performance results are presented for regions of clutter power transitions and for multiple target environments to illustrate the possible improvement over the order-statistic detector that can be obtained by using a VTM detector.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
REDUNDANT FIRMWARE TEST SETUP IN SIMULATION AND HARDWARE: A FEASIBILITY STUDY (2018)

A reliable embedded real-time system has many requirements to fulfil. It must meet target deadlines in a number of situations, most of them in a situation that puts heavy stress on the system. To meet these demands, numerous tests have been created which test the hardware for any possible errors the developers might think of, in order to maximise system reliability and stability. These tests will take a lot of time to execute, and as system complexity grows, more tests are introduced leading to even longer testing times. In this thesis, a method to reduce the testing time of the software and, to a lesser extent, the hardware is examined. By using the full system simulator Simics, an existing industry system from ABB was integrated and tests were performed. A proof of concept test suite for automatic redundancy tests was also implemented. By looking at the test results, it was concluded that the method shows promise. However, problems with the average latency and performance troubles with Simics shows that more work must be put into this research before the system can be run at full speed.