gebhart/patrepeval huggingface dataset:
Transient Response of a Wind Energy Conversion System Used as Active Filter (2010)

This paper details the transient operation of a wind energy conversion system (WECS) used simultaneously as an active filter and power generator. This study is intended to address the system response to two types of transient phenomena: voltage dips (fast transients) and wind speed variations (slow transients). The system response to voltage dips is governed by the electrical system dynamics and control method and results in the evaluation of the WECS low-voltage ride through capability. The study of the system response to wind speed variations requires a complete mechanical model to be included. Simulation results are presented for a typical WECS, and a discussion is carried out dealing with the generalization of the present work to other configurations.
Microemulsion polymerization of microlatex in sublimation ink for cotton fabric ink jet printing (2011)

Abstract A novel microlatex of styrene/2‐ethylhexylacrylate (2‐EHA)/2‐hydroxyethyl methacrylate (2‐HEMA)/N‐(isobutoxy methyl) acrylamide (IBMA) copolymer was synthesized and mixed in sublimation inks to be inkjet printed on the cotton fabric to provide soft hand feel and good color fastness after heat‐press. In the optimized microemulsion composition with highest monomer mixture amount, polymerizable maleate surfactants with moderate EO value attained smaller microemulsion droplet size in mono distribution and lower dosage than conventional POE surfactants in combination with anionic surfactants. With adopted semicontinuous process in microemulsion copolymerization at 65°C, the polymerizable surfactants stabilized the growth of microlatex particle size within 70 nm in 240 min and attained 100% of monomer conversion rate with two initiator systems, 2‐2‐azobis(2‐methlypropionamidine dihydrochloride (AAPH) and tert ‐butylhydroperoxide (TBHP)/sodium formaldehyde sulfoxylate (SFS). The microlatex particle size of two surfactant systems increased with higher conversion rate and reaction temperature, which synchronized with initiator concentration. High polymer solid content was contributed mainly by IBMA monomer ratio requiring higher amounts of anionic surfactants and 2‐HEMA as a cosurfactant in particle stabilization. Although the optimum ink containing high IBMA microemulsion exhibited small variation in viscosity, pH value and surface tension, disperse dyes in four colors had different interaction with the microlatex to demonstrate distinct printing durability and color performance. The resulted cotton fabric attained high K/S value for color strength, great AATCC grade for color fastness, and nearly zero color difference for negative dye particle diffusion or migration. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Learning from summaries of videos: Applying batch mode active learning to face-based biometrics (2010)

Against the backdrop of growing concerns about security and privacy, biometrics has emerged as a methodology to reliably infer the identity of an individual. In biometric applications like face recognition, real world data is usually generated in batches such as frames of video in a capture session. The captured data has high redundancy and it is a significant challenge to select the most promising instances from this superfluous set for training a classifier. Active learning methods select only the salient instances for annotation and have gained popularity to reduce the number of examples required to learn a classification model. Typical active learning techniques select one example from an unlabeled set at a time and the classifier is retrained after every selected example. However, there have been very limited efforts in this field to select a batch of salient instances at one shot to update the classification model. In this work, a novel batch mode active learning scheme, specifically tailored to handle the high redundancy of biometric data, has been formulated and validated on the person recognition problem. The instance selection is based on numerical optimization of an objective function, which can be adapted to suit the requirements of a particular application and to integrate additional available information. The results obtained on the widely used VidTIMIT and the NIST MBGC datasets certify the potential of this method in being used for real world biometric recognition problems.
Nonuniform Compression in Databases with Haar Wavelet (2007)

Data synopsis is a lossy compressed representation of data stored into databases that helps the query optimizer to speed up the query process, e.g. time to retrieve the data from the database. An efficient data synopsis must provide accurate information about the distribution of data to the query optimizer at any point in time. Due to the fact that some data will be queried more often than others, a good data synopsis should consider the use of nonuniform accuracy, e.g. provide better approximation of data that are queried the most. Although, the generation of data synopsis is a critical step to achieve a good approximation of the initial data representation, data synopsis must be updated over time when dealing with time varying data. In this paper, we introduce new Haar wavelet synopses for nonuniform accuracy and time-varying data that can be generated in linear time and space, and updated in sublinear time. The efficiency of our new data synopses is validated against other linear methods by using both synthetic and real data sets
IL-10 and the Dangers of Immune Polarization: Excessive Type 1 and Type 2 Cytokine Responses Induce Distinct Forms of Lethal Immunopathology in Murine Schistosomiasis (2000)

To dissect the controversial roles of type 1 and type 2 cytokines to the pathogenesis of schistosomiasis, we generated IL-10/IL-4- and IL-10/IL-12-deficient mice that develop highly polarized type 1 and type 2 cytokine responses, respectively. Interestingly, the Th1-polarized IL-10/IL-4-deficient mice rapidly lost weight at the onset of egg-laying and displayed 100% mortality by wk 9 postinfection. This acute mortality was linked to overexpression of the proinflammatory mediators IFN-gamma, TNF-alpha, and inducible NO and the formation of nonfibrotic granulomas. Elevated serum aspartate transaminase levels confirmed that mortality was in part attributable to acute hepatotoxicity. In contrast, the Th2-polarized IL-10/IL-12-deficient mice developed a progressive wasting disease that correlated with increased hepatic fibrosis, formation of large eosinophil-rich granulomas, a 10-fold increase in IL-4 and IL-13, and significant mortality during the chronic stages of infection. Surprisingly, IL-10-deficient mice displayed pathological features that were characteristic of both extremes, while wild-type mice developed relatively successful long term chronic infections. These data demonstrate that IL-10 significantly suppresses type 1 and type 2 cytokine development in IL-4- and IL-12-deficient mice, respectively, thereby impeding the development of severe egg-induced pathology in the single cytokine-deficient animals. Together, these findings reveal the central regulatory role of IL-10 in the pathogenesis of schistosomiasis and illustrate that excessive type 1 and type 2 cytokine responses trigger distinct, but equally detrimental, forms of pathology following infection.
Master Thesis Communication Filters for Distributed Optimization with the Parameter Server (2015)

One of the bottlenecks for distributed machine learning system is the huge communication overhead. In this thesis, we explore the filtering idea to tackle this problem and narrow down the scope to study distributed optimization under parameter server framework. We first discuss the intuition in designing filters based on the redundancy hidden in optimization algorithms. We then derived convergence conditions in applying filters. Based on these analysis, we provide efficient algorithms using sampling and randomized rounding techniques. For applying filters in practice, we also discuss strategies in filtering jointly and the scalability influence. The filters are experimentally proved to be able to reduce communication cost significantly without affecting the learning performance.
Molecular Targets for Selenium in Cancer Prevention (2001)

Mounting evidence reveals that selenium is a dietary constituent with anticarcinogenic and antitumorigenic properties. Various forms of selenium appear to be effective in bringing about these effects, although preclinical studies suggest that differences may arise as the quantity provided is reduced. The literature also documents the greater sensitivity of neoplastic cells to selenium than their nonneoplastic counterparts. Unfortunately, the minimal amount needed to bring about a positive effect in humans remains elusive. If there is a positive response to exaggerated intakes, it will likely be dependent on many factors, including the consumption of other dietary constituents, as well as variation in a host of genetic pathways involved with cancer. Although the biological basis of the reduction in cancer risk ascribed to selenium remains to be established, its consistency in retarding various experimentally induced tumors and suppressing the growth of various types of neoplasms in vitro and in vivo suggests that several mechanisms are involved. Depressed carcinogen bioactivation, reduced cell proliferation, and increased apoptosis raise the possibility that selenium works at a number of specific molecular targets involved with the cancer process. This review will focus on molecular targets involved with cell proliferation and apoptosis as possible mechanisms by which selenium might alter the cancer process.
The Structure of Aristotelian Logic. (1939)

Originally published in 1938. This compact treatise is a complete treatment of Aristotle’s logic as containing negative terms. It begins with defining Aristotelian logic as a subject-predicate logic confining itself to the four forms of categorical proposition known as the A, E, I and O forms. It assigns conventional meanings to these categorical forms such that subalternation holds. It continues to discuss the development of the logic since the time of its founder and address traditional logic as it existed in the twentieth century. The primary consideration of the book is the inclusion of negative terms - obversion, contraposition etc. – within traditional logic by addressing three questions, of systematization, the rules, and the interpretation.
Beneficial effects of vaccenic acid on postprandial lipid metabolism and dyslipidemia: Impact of natural <i>trans</i>‐fats to improve CVD risk (2010)

Abstract Abnormal non‐fasting (postprandial) lipid metabolism has been recognized as a significant contributor to dyslipidemia and cardiovascular disease (CVD) risk. Clinically, impaired metabolism of lipoproteins following a meal (e.g. chylomicrons) has been demonstrated in a number of chronic diseases, including obesity, insulin resistance, as well as type 1 and 2 diabetes. Given the proposed effects of dietary trans fat to contribute to a lipid profile that increases CVD risk, there has been a public health campaign in many countries to eliminate these fatty acids from the food supply. In contrast, our group has recently reported novel lipid‐lowering benefits of a major naturally‐occurring trans fatty acid vaccenic acid (VA, shorthand lipid name 18:1 trans‐11), in an animal model of dyslipidemia and the metabolic syndrome. Studies to date have shown that dietary supplementation of VA effectively reduces not only fasting lipids, but also postprandial triacylglycerol and chylomicron concentrations in obese JCR:LA‐cp rats. Evidence from animal studies to date suggest that VA may down‐regulate hepatic fatty acid synthesis and directly influence lipogenesis in the intestine. The discovery of new bioactive properties of VA is supported by clinical studies which have provided increased momentum for industry applications. In this review we summarize the emerging beneficial view of natural trans fats that have distinct and differential properties compared to those synthetically produced in partially hydrogenated vegetable oils (PHVO), with a particular focus on fasting and postprandial lipid metabolism in CVD risk.
Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic ( <i>Hyp</i> ) mouse model (2009)

Hyp mice possess a mutation that inactivates the phosphate-regulating gene, which is homologous to the endopeptidases of the X-chromosome (PHEX). The mutation is associated with severe hypophosphatemia due to excessive urinary phosphate wasting. Such urinary phosphate wasting in Hyp mice is associated with an increased serum accumulation of fibroblast growth factor (FGF) 23. We wanted to determine the biological significance of increased serum FGF23 levels and concomitant hypophosphatemia in Hyp mice and to evaluate whether FGF23 activity could be modified by manipulating klotho (a cofactor of FGF23 signaling). We generated Hyp and klotho double-mutant mice (Hyp/klotho(-/-)). Severe hypophosphatemia of Hyp mice was reversed to hyperphosphatemia in Hyp/klotho(-/-) double mutants, despite the fact that the double mutants showed significantly increased serum levels of FGF23. Hyperphosphatemia in Hyp/klotho(-/-) mice was associated with increased renal expression of sodium/phosphate cotransporter 2a (NaPi2a) protein. Exogenous injection of bioactive parathyroid hormone 1-34 down-regulated renal expression of NaPi2a and consequently reduced serum levels of phosphate in Hyp/klotho(-/-) mice. Moreover, in contrast to the Hyp mice, the Hyp/klotho(-/-) mice showed significantly higher serum levels of 1,25-dihydroxyvitamin D and developed extensive calcification in soft tissues and vascular walls. Furthermore, compared with the Hyp mice, Hyp/klotho(-/-) mice were smaller in size, showed features of generalized tissue atrophy, and generally died by 15-20 wk of age. Our in vivo studies provide genetic evidence for a pathological role of increased FGF23 activities in regulating abnormal phosphate homeostasis in Hyp mice. Moreover, these results suggest that even when serum levels of FGF23 are significantly high, in the absence of klotho, FGF23 is unable to regulate systemic phosphate homeostasis. Our in vivo observations have significant clinical implications in diseases associated with increased FGF23 activity and suggest that the functions of FGF23 can be therapeutically modulated by manipulating the effects of klotho.
An efficient FFT twiddle factor generator (2004)

Twiddle factor (TF) generator is a key component in IFFT/FFT computation for current OFDM-based wireless and wireline communication systems, such as IEEE 802.11a/g, 802.16, VDSL, DVB, DAB systems. In this paper, we propose an efficient TF generator design. The proposed design combines an efficient conventional recursive sine/cosine function generation algorithm with a small compensation lookup table. The compensation table solves the error propagation problem of a recursive TF generator. It also costs less area than the existing modified recursive sine/cosine function generator. The proposed design requires only two constant multipliers, two adders, and two correction tables, which is smaller than those polynomial-based complex sine function generators. Simulation results show that the proposed design is favourable over the existing TF generators for general FFT lengths in practical applications, except for small lengths such as 64 up to 512. For those s-mall FFT lengths, ROM-based is a better choice. 1.
Capecitabine Maintenance Therapy after First-Line Chemotherapy in Patients with Metastatic Colorectal Cancer (2010)

Objective:To evaluate the efficacy and toxicity of capecitabine maintenance therapy in metastatic colorectal cancer(mCRC) patients.Methods:From June 2001 to November 2006,after they had achieved clinical response from first-line chemotherapy,patients with mCRC in our hospital received two different treatment strategies.Thirty-three patients in maintenance group were treated with capecitabine 1000 mg/m2 po bid d1-14,q21d.Fifty-two patients in non-maintenance group did not receive any further chemotherapy.Results:Patients in maintenance group and non-maintenance group both received FOLFOX,FOLFIRI and XELOX as first-line therapy.The median chemotherapy cycles the two groups received were the same(6 vs 6).The response rates of first-line chemotherapy were 33.3% in maintenance group and 32.7% in non-maintenance group.Patients in maintenance group received 3-9 cycles of capecitabine therapy(median cycle 4).29/33(87.9%) patients in maintenance group and 47/52(90.4%) in non-maintenance group received following second-line chemotherapy,and no patients underwent targeted therapy.The median survival time and TTP were 40.4 months(95%CI:24.2-56.6) and 9.0 months(95%CI:6.7-11.3) in maintenance group,as compared with 21.5 months(95%CI:14.9-28.0,P=0.015) and 6.5 months(95%CI:4.4-8.5,P=0.007) in non-maintenance group.No severe adverse event was observed in the capecitabine maintenance group.Conclusion:mCRC patients could benefit from capecitabine maintenance therapy by prolonging survival time and TTP.
Complementary therapy and survival in glioblastoma (2015)

Abstract Background Complementary therapy (CAM) is common in cancer patients. We undertook this study to assess the association of complementary therapy usage with mortality in glioblastoma (GBM) patients. Methods The analysis was based on 470 patients. Information on current use of CAM was collected in structured interviews conducted a median of 6 weeks following GBM diagnosis. Proportional hazards regression was used to estimate hazard ratios (HRs) for GBM-related death according to the use of individual supplements with multivariate adjustment for known prognostic factors including age, KPS, and extent of tumor resection (ESR). Results Use of CAM agents was common, with 77% of the cohort reporting CAM usage. No mortality association was observed with the use of multivitamins (HR = 0.91; P = .40) or omega-3 fatty acids (HR = 1.07; P = .69). Patients taking vitamin D as an individual supplement (containing higher dosages than in a multivitamin) had reduced mortality when compared with nonusers (age-adjusted HR = 0.68; P = .02). However, the association was diminished after adjustment for KPS and ESR (HR = 0.74; P = .09). Use of herbal supplements was also associated with reduced mortality (HR = 0.58; P = .04). Vitamin E users had a nonsignificantly higher mortality when compared with nonusers (HR = 1.54; P = .09). Conclusions Use of CAM is common in GBM patients. These exploratory analyses suggest no mortality association with the use of multivitamins or omega-3 fatty acids. Associations observed with vitamins D and E merit further investigation.
Making Savers Winners: An Overview of Prize-Linked Savings Products (2010)

For over three centuries and throughout the globe, people have enthusiastically bought savings products that incorporate lottery elements. In lieu of paying traditional interest to all investors proportional to their balances, these Prize Linked Savings (PLS) accounts distribute periodic sizeable payments to some investors using a lottery-like drawing where an investor’s chances of winning are proportional to one’s account balances. This paper describes these products, provides examples of their use, argues for their potential popularity in the United States —especially to low and moderate income non-savers—and discusses the laws and regulations in the United States that largely prohibit their issuance.
Passenger Profiling: A Greater Terror Than Terrorism Itself, 32 J. Marshall L. Rev. 167 (1998) (1998)

History teaches that grave threats to liberty often come in times of urgency, when constitutional
Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure (2019)

Sporadic literature reports describe isolates of pathogenic bacteria that harbor an antibiotic resistance determinant but remain susceptible to the corresponding antibiotic as a consequence of a genetic defect. Such strains represent a source from which antibiotic resistance may reemerge to cause treatment failure in patients. Here, we report a systematic investigation into the prevalence and nature of this phenomenon, which we term <u>s</u>ilencing of <u>a</u>ntibiotic <u>r</u>esistance by <u>m</u>utation (SARM). Instances of SARM were detected among 1,470 <i>Staphylococcus aureus</i> isolates through side-by-side comparison of antibiotic resistance genotype (as determined by whole-genome sequencing) versus phenotype (as assessed through susceptibility testing). Of the isolates analyzed, 152 (10.3%) harbored a silenced resistance gene, including 46 (3.1%) that exhibited SARM to currently deployed antistaphylococcal drugs. SARM resulted from diverse mutational events but most commonly through frameshift mutation of resistance determinants as a result of point deletion in poly(A) tracts. The majority (∼90%) of SARM strains reverted to antibiotic resistance at frequencies of ≥10<sup>-9</sup>; thus, while appearing antibiotic sensitive in the clinical microbiology laboratory, most <i>S. aureus</i> isolates exhibiting SARM will revert to antibiotic resistance at frequencies achievable in patients. In view of its prevalence in a major pathogen, SARM represents a significant potential threat to the therapeutic efficacy of antibiotics.<b>IMPORTANCE</b> Antibiotic resistance hinders the treatment of bacterial infection. To guide effective therapy, clinical microbiology laboratories routinely perform susceptibility testing to determine the antibiotic sensitivity of an infecting pathogen. This approach relies on the assumption that it can reliably distinguish bacteria capable of expressing antibiotic resistance in patients, an idea challenged by the present study. We report that the important human pathogen <i>Staphylococcus aureus</i> frequently carries antibiotic resistance genes that have become inactivated ("silenced") by mutation, leading strains to appear antibiotic sensitive. However, resistance can rapidly reemerge in most such cases, at frequencies readily achievable in infected patients. Silent antibiotic resistance is therefore prevalent, transient, and evades routine detection, rendering it a significant potential threat to antibacterial chemotherapy.
Revisiting the modeling of user association patterns in a university wireless network (2018)

This paper presents an analysis of a large trace of user associations in a university wireless network, which includes around one thousand access points over five campuses. The trace is obtained from RADIUS authentication logs and its merit is in its recency, scale and duration. We propose a methodology for extracting association statistics from these logs, and look at visiting time distributions and processes of user arrivals to access points. We find that a large fraction of the network - around half of all access points - experiences time-varying Poisson arrival process, and association distributions can be modeled by two-stage hyper-exponential distributions at most of the access point. While network associations in campus wireless networks have been extensively studied in the literature, our study reveals changing patterns in user arrival processes and association durations, which seem to be characteristic for networks of predominantly mobile users, and allows the use of tractable network occupancy models.