gebhart/patrepeval huggingface dataset:
Polymer coatings and delayed arterial healing following drug-eluting stent implantation. (2009)

The antirestenotic efficacy of drug-eluting stent (DES) technology is based on the local delivery and modulated release of cytotoxic drugs targeted at inhibition of neointimal hyperplasia. Control of drug-release kinetics is a critical component of device efficacy. To date this has been most effectively performed by stent coatings comprised of non-erodable (permanent) polymer which facilitate drug loading and delay elution of the active drug. In fact all 4 of the systems currently approved by the Food and Drug Administration (FDA) use a permanent polymer-based drug release system. Balancing the need for lipophilicity (to bind active drug) with hydrophilicity (which offers superior biocompatibility) is a key challenge in polymer technology. Delayed arterial healing (DAH) following DES implantation has been demonstrated in human autopsy studies and animal models and is implicated in late thrombotic occlusion and delayed loss of antirestenotic efficacy. It is characterised by 1) persistent fibrin deposition; 2) delayed endothelialization; 3) chronic inflammation; and 4) persistent platelet activation. Within segment heterogeneity in degree of healing is typical. Inflammatory response to polymer residue plays an important role and may be non-specific (monocyte-macrophage predominant) or hypersensitivity related. Failure of early preclinical models to sufficiently predict DAH in man was an important problem. Second generation DES attempt to address the issue of DAH by using thinner stent struts, lower drug load and more biocompatible polymer. At present the focus of development is towards biodegradable polymer coatings which offer the attractive prospect of controlled drug-release without the potential for late polymer-associated adverse effects. This review highlights the role of polymer coatings in determination of DES efficacy, summarises the preclinical and clinical evidence linking polymer coatings with DAH and evaluates the promise of third generation polymer-free and biodegradable polymer DES.
Privacy-Preserving Outsourced Profiling (2010)

Personalized services attract high-value customers. Knowing the preferences and habits of an individual customer, it is possible to offer to that customer well customized and adapted services, matching his needs and desires. This is advantageous for the entity offering the service (e.g., a retailer) as well, as it helps in creating additional sales or improve customer retention. The main unsolved problem today is that the profile of each individual customer would be necessary in order to create such services, posing severe risks regarding privacy and data protection. This paper proposes efficient encryption schemes that allow profiling to be outsourced while preserving privacy. The schemes ensure that the customer is always in control of his profile data, at the same time making shopping data across multiple retailers available to third party service providers to be able to provide targeted services.
Unified multiple‐feature color display for MR images (1989)

A display method is proposed in which the spin-lattice relaxation time T1, the spin-spin relaxation time T2, and the proton density rho of each pixel in a MR image are simultaneously expressed in color features in a unified way that allows international standardization. MR images were made from a phantom, a healthy volunteer, and patients in such a way that T1 and T2 and proton density images could be derived. T1 and T2 data were compared with accurate relaxation time measurements of the phantom content. Color images were computed from the acquired T1 and T2 images using matrix multiplication on a pixel base. In this way the color combination in each pixel represents the properties of that particular pixel by a unique mixing of the elementary colors red, green, and blue. Color resolution could be modified using different choices of the reference triangle in which the color combinations were defined. This method of representation offers a means for displaying multiple features as T1 and T2 in one directly interpretable image, independent of instrumental settings.
Severe Acute Respiratory Syndrome Coronavirus 7a Accessory Protein Is a Viral Structural Protein (2006)

Severe acute respiratory syndrome coronavirus (SCoV) 7a protein is one of the viral accessory proteins. In expressing cells, 7a protein exhibits a variety of biological activities, including induction of apoptosis, activation of the mitogen-activated protein kinase signaling pathway, inhibition of host protein translation, and suppression of cell growth progression. Analysis of SCoV particles that were purified by either sucrose gradient equilibrium centrifugation or a virus capture assay, in which intact SCoV particles were specifically immunoprecipitated by anti-S protein monoclonal antibody, demonstrated that 7a protein was associated with purified SCoV particles. Coexpression of 7a protein with SCoV S, M, N, and E proteins resulted in production of virus-like particles (VLPs) carrying 7a protein, while 7a protein was not released from cells expressing 7a protein alone. Although interaction between 7a protein and another SCoV accessory protein, 3a, has been reported, 3a protein was dispensable for assembly of 7a protein into VLPs. S protein was not required for the 7a protein incorporation into VLPs, and yet 7a protein interacted with S protein in coexpressing cells. These data established that, in addition to 3a protein, 7a protein was a SCoV accessory protein identified as a SCoV structural protein.
Reward Value-Based Gain Control: Divisive Normalization in Parietal Cortex (2011)

The representation of value is a critical component of decision making. Rational choice theory assumes that options are assigned absolute values, independent of the value or existence of other alternatives. However, context-dependent choice behavior in both animals and humans violates this assumption, suggesting that biological decision processes rely on comparative evaluation. Here we show that neurons in the monkey lateral intraparietal cortex encode a relative form of saccadic value, explicitly dependent on the values of the other available alternatives. Analogous to extra-classical receptive field effects in visual cortex, this relative representation incorporates target values outside the response field and is observed in both stimulus-driven activity and baseline firing rates. This context-dependent modulation is precisely described by divisive normalization, indicating that this standard form of sensory gain control may be a general mechanism of cortical computation. Such normalization in decision circuits effectively implements an adaptive gain control for value coding and provides a possible mechanistic basis for behavioral context-dependent violations of rationality.
The application of mean field theory to image motion estimation (1995)

Previously, Markov random field (MRF) model-based techniques have been proposed for image motion estimation. Since motion estimation is usually an ill-posed problem, various constraints are needed to obtain a unique and stable solution. The main advantage of the MRF approach is its capacity to incorporate such constraints, for instance, motion continuity within an object and motion discontinuity at the boundaries between objects. In the MRF approach, motion estimation is often formulated as an optimization problem, and two frequently used optimization methods are simulated annealing (SA) and iterative-conditional mode (ICM). Although the SA is theoretically optimal in the sense of finding the global optimum, it usually takes many iterations to converge. The ICM, on the other hand, converges quickly, but its results are often unsatisfactory due to its "hard decision" nature. Previously, the authors have applied the mean field theory to image segmentation and image restoration problems. It provides results nearly as good as SA but with much faster convergence. The present paper shows how the mean field theory can be applied to MRF model-based motion estimation. This approach is demonstrated on both synthetic and real-world images, where it produced good motion estimates.
STARS Is Essential to Maintain Cardiac Development and Function In Vivo via a SRF Pathway (2012)

This study demonstrates for the first time that STARS deficiency severely disrupts cardiac development and function in vivo and revealed a novel STARS-SRF feed-forward autoregulatory loop that could play an essential role in STARS regulation and cardiac function.
Pattern independent maximum current estimation in power and ground buses of CMOS VLSI circuits: Algorithms, signal correlations, and their resolution (1995)

Currents flowing in the power and ground (P&G) buses of CMOS digital circuits affect both circuit reliability and performance by causing excessive voltage drops. Excessive voltage drops manifest themselves as glitches on the P&G buses and cause erroneous logic signals and degradation in switching speeds. Maximum current estimates are needed at every contact point in the buses to study the severity of the voltage drop problems and to redesign the supply lines accordingly. These currents, however, depend on the specific input patterns that are applied to the circuit. Since it is prohibitively expensive to enumerate all possible input patterns, this problem has, for a long time, remained largely unsolved. In this paper, we propose a pattern-independent, linear time algorithm (iMax) that estimates at every contact point, an upper bound envelope of all possible current waveforms that result by the application of different input patterns to the circuit. The algorithm is extremely efficient and produces good results for most circuits as is demonstrated by experimental results on several benchmark circuits. The accuracy of the algorithm can be further improved by resolving the signal correlations that exist inside a circuit. We also present a novel partial input enumeration (PIE) technique to resolve signal correlations and significantly improve the upper bounds for circuits where the bounds produced by iMax are not tight. We establish with extensive experimental results that these algorithms represent a good time-accuracy trade-off and are applicable to VLSI circuits.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A stable self-organizing fuzzy controller for robotic motion control (2000)

It is well known that robotic manipulators are highly nonlinear coupling dynamic systems. It is difficult to establish an appropriate mathematical model for the design of a model-based controller. Although fuzzy logic control has a model-free feature, it still needs time-consuming work for the rules bank and fuzzy parameters adjustment. In this paper, a stable self-organizing fuzzy controller (SOFC) is proposed to manipulate the motion trajectory of a 5-degrees-of-freedom robot. This approach has a learning ability for responding to the time-varying characteristic of a robot. Its control rules bank can be established and modified continuously by online learning with zero initial fuzzy rules. In addition, this control strategy has effectively improved the stability problem of a previous SOFC. The experimental results show that this intelligent controller has a stable learning ability and good motion control capability.
A Program Development Tool (1984)

In this paper we describe how we have combined a number of tools (most of which are tailored to a particular programming language) into a single system to aid in the reading, writing, and running of programs. We discuss the efficacy and the structure of two such systems, one of which has been used to build several large application programs. We report some of the experience we have gained in evolving these systems. We first describe the system components which users have found most important; some of the facilities described here are new in the literature. Second, we attempt to show how these tools form a synergistic union, and we illustrate this point with a number of examples. Third, we illustrate the use of various system commands in the development of a simple program. Fourth, we discuss the implementation of the system components and indicate how some of them have been generalized.
An accelerometer interface circuit (2002)

This paper presents an interface circuit which converts the femtofarad-level signal from an accelerometer's capacitive sense element to a pulse signal suitable for digital signal processing. Calibration circuitry compensates for the offset and sensitivity variations in the sense element and for packaging variability. The circuit has been fabricated in a 1.6 /spl mu/m CMOS process. Test results show very low sensitivity to variations in temperature or supply voltage.
Synthesis of Ascididemine and an Isomer (2000)

Ascididemine (9H-quino[4,3,2-de][1,10]phenanthrolin-9-one) (1) and an isomer (9H-quino[4,3,2-de][1,7]phenanthrolin-9-one) (4) have been synthesized starting from 1,4-dimethoxyacridone (7). The acridone was converted into 1,4-dimethoxy-9-ethynylacridine (11) by a triflate coupling. The ethynylacridine was converted in one-pot into 3H-6-methoxypyrido[2,3,4-kl]acridine (15) by reaction with sodium diformylamide; the mechanism of this key transformation is discussed. Conversion into 6H-4-bromopyrido[2,3,4-kl]acridin-6-one (19) and 6H-pyrido[2,3,4-kl]acridin-6-one (17), followed by reaction of each of these under high pressure conditions with acrolein N,N-dimethylhydrazone, gave ascididemine and its isomer, respectively.
Characterization of Fifty Putative Inclusion Membrane Proteins Encoded in the<i>Chlamydia trachomatis</i>Genome (2008)

Although the Chlamydia trachomatis genome is predicted to encode 50 inclusion membrane proteins, only 18 have been experimentally localized in the inclusion membrane of C. trachomatis-infected cells. Using fusion proteins and anti-fusion protein antibodies, we have systematically evaluated all 50 putative inclusion membrane proteins for their localization in the infected cells, distribution patterns, and effects on subsequent chlamydial infection when expressed ectopically, as well as their immunogenicity during chlamydial infection in humans. Twenty-two of the 50 proteins were localized in the inclusion membrane, and 7 were detected inside the inclusions, while the location of the remaining 21 was not defined. Four (CT225, CT228, CT358, and CT440) of the 22 inclusion membrane-localized proteins were visualized in the inclusion membrane of Chlamydia-infected cells for the first time in the current study. The seven intra-inclusion-localized proteins were confirmed to be chlamydial organism proteins in a Western blot assay. Further characterization of the 50 proteins revealed that neither colocalization with host cell endoplasmic reticulum nor inhibition of subsequent chlamydial infection by ectopically expressed proteins correlated with the inclusion membrane localization. Interestingly, antibodies from women with C. trachomatis urogenital infection preferentially recognized proteins localized in the inclusion membrane, and the immunodominant regions were further mapped to the region predicted to be on the cytoplasmic side of the inclusion membrane. These observations suggest that most of the inclusion membrane-localized proteins are both expressed and immunogenic during C. trachomatis infection in humans and that the cytoplasmic exposure may enhance the immunogenicity.
SORPTION OF FIPRONIL AND ITS METABOLITES ON SOILS FROM SOUTH AUSTRALIA (2001)

This paper reports on the sorption of fipronil [(+/-)-5-amino-1-(2,6-dichloro-alpha,alpha,alpha-trifluoro-p-tolyl)-4-trifluoromethyl-sulfinylpyrazole-3-carbonitrile] and its two main metabolites, desulfynil and sulfide derivatives on a range of soils from South Australia. The Freundlich sorption coefficient (Kf) values for fipronil on the soils ranged from 1.94 to 4.84 using a 5% acetonitrile/water mixture as the soil solution. Its two metabolites had a higher sorption affinity for soils, with Kf values ranging from 11.09 to 23.49 for the sulfide derivative and from 4.70 to 11.77 for the desulfynil derivative. Their sorption coefficients were found to be better related to the soil organic carbon than clay content. The presence of cosolvents in soil solutions had a significant influence on the sorption of fipronil. The Freundlich sorption coefficients showed a log linear relationship with the fractions of both acetonitrile and methanol in solutions. The sorption coefficient of fipronil on Turretfield soil in the aqueous solution was estimated to be from 13.80 to 19.19. Methanol had less effect on the sorption of fipronil than acetonitrile. The Kd values for fipronil on the eight soils using a 5% methanol/water mixture were from 5.34 to 13.85, which reflect more closely the sorption in the aqueous solution. The average Koc value for fipronil on the eight South Australian soils was calculated to be 825+/-214.
A Dynamic Model of Purchase Timing with Application to Direct Marketing (1999)

Abstract Predicting changes in individual customer behavior is an important element for success in any direct marketing activity. In this article we develop a hierarchical Bayes model of customer interpurchase times based on the generalized gamma distribution. The model allows for both cross-sectional and temporal heterogeneity, with the latter introduced through the component mixture model dependent on lagged covariates. The model is applied to personal investment data to predict when and if a specific customer will likely increase time between purchases. This prediction can be used managerially as a signal for the firm to use some type of intervention to keep that customer. Key Words: Generalized gamma distributionHierarchical BayesPanel data
Analytical Method for Ethoprop (Mocap) in Agricultural Crops (1982)

An analytical method for multiresidues of organochlorine and organophosphorus pesticides, including ethoprop (O-ethyl S, S-dipropylphosphorodithioate, prophos, Mocap®), a nematocide, in crops was developed.The method consisted of extraction with a mixture of acetone and n-hexane, clean-up by florisil column chromatography and determination by gas chromatography (GC). The pesticides on the column were eluted with 200ml each of 15% ether in n-hexane and ether. Ethoprop was eluted in the second fraction and determined by FPD-GC, organochlorine pesticides were eluted in the first fraction and determined by ECD-GC, and organophosphorus pesticides were eluted in both fractions and determined by FPD-GC.A recovery test was carried out by fortification of 5 crops, and the recoveries of ethoprop were in the range of 81% to 95%. The recoveries of organophosphorus pesticides from banana and corn were in the range of 71% to 96%. Furthermore, ethoprop in banana could be identified by GC-MS.
Effect of Screening and Adjuvant Therapy on Mortality from Breast Cancer (2005)

Seven statistical models showed that both screening mammography and treatment have helped reduce the rate of death from breast cancer in the United States.
Electronic Signature Policies (2001)

This document defines signature policies for electronic signatures.A signature policy is a set of rules for the creation and validation of an electronic signature, under which the validity of signature can be determined.A given legal/contractual context may recognize a particular signature policy as meeting its requirements.A signature policy has a globally unique reference, which is bound to an electronic signature by the signer as part of the signature calculation.The signature policy needs to be available in human readable form so that it can be assessed to meet the requirements of the legal and
Simulating Multizone Fracturing in Vertical Wells (2014)

Numerous multizone multistage hydraulic fracturing treatments are now being executed in low permeability oil and gas fields around the world. Due to the limited access to the subsurface, post-treatment assessments are mainly limited to few techniques such as tiltmeter, microseismic, and tracer-logs. The first two techniques are mainly used to determine fracture extension; however, fracture height and fracture initiation at all perforation clusters could only be confirmed through radioactive tracer logs or detailed pressure analysis. In this paper, we consider real examples from a field from Central America and investigate potential problems that led to the limited generation of fractures in multizone treatments. For instance, some of the postfrac radioactive logs show very low concentration of tracers at some perforated zones in comparison with other zones. On the other hand in some cases, tracer logs indicate the presence of tracers in deeper or shallower zones. Different reasons could cause fracture growth in nonperforated zones, including but not limited to: perforation design problems, casing/cement integrity problems, lack of containment, instability of fracture growth in one or some of the zones, and finally making a mistake in selecting lithology for fracturing. In this paper, some of these issues have been examined for a few sample wells using treatment pressure data, petrophysical logs, and postfrac tracer logs. Some recommendations in designing the length and arrangement of perforations to avoid these problems in future fracturing jobs are provided at the end of this paper.
Fluorouracil: biochemistry and pharmacology. (1988)

Fluorouracil (5FU) is still considered the most active antineoplastic agent in the treatment of advanced colorectal cancer. The drug needs to be converted to the nucleotide level in order to exert its effect. It can be incorporated into RNA leading to interference with the maturation of nuclear RNA. However, its conversion to 5-fluoro-2'deoxy-5' monophosphate (FdUMP) leading to inhibition of thymidylate synthase (TS) and subsequently of DNA synthesis, is considered to be its main mechanism of action. In the presence of a folate cofactor a covalent ternary complex is formed, the stability of which is the main determinant of the action of 5FU. Resistance against 5FU can be mainly attributed to aberrations in its metabolism or to alterations of TS, eg, gene amplification, altered kinetics in respect to nucleotides or folates. Biochemical modulation of 5FU metabolism can be applied to overcome resistance against 5FU. A variety of normal purines, pyrimidines, and other antimetabolites have been studied in this respect, but only some of them have been clinically successful. Delayed administration of uridine has recently been shown to "rescue" mice and patients from toxicity, while pretreatment with leucovorin is the most promising combination to enhance the therapeutic efficacy. 5FU is frequently administered in an intravenous (IV) injection, and shows a rapid distribution and a triphasic elimination. The nonlinearity of 5FU pharmacokinetics is related to saturation of its degradation. Continuous infusion of 5FU led to different kinetics. Regional administration, such as hepatic artery infusion, offers a way to achieve higher drug concentrations in liver metastases and is accompanied by lower systemic concentration. The current status of the biochemical and pharmacokinetic data is reviewed.