gebhart/patrepeval huggingface dataset:
Late-breaking abstract: Inhaled calcium salts reduce tobacco smoke induced airway inflammation and improve lung pathology (2011)

Rationale: Acute exacerbations (AE) of COPD are associated with bacterial and viral infection, however no available therapy broadly targets infection to prevent AEs. We have developed a novel host-targeted therapy based on the inhalation of dry powder (DP) calcium (Ca) salts that is broadly anti-infective and applicable to AE control. The goal of this study was to evaluate the impact of inhaled Ca salts on inflammation in an acute model of tobacco smoke (TS) exposure. Methods: C57BL6 mice were exposed to TS for 4d or 11d. Treatments with salt-based DP (40μmol/kg) were delivered by inhalation exposure. A p38 MAP kinase inhibitor (100μg/kg) was used as a positive control. Mice were euthanized 24h after the last TS exposure, BAL cells were quantified and histopathology performed. Results: In a 4d exposure model, treatment with Ca-based DP (PUR118) once daily 1h or 6h before TS reduced inflammatory cells [for 1h, macrophages (52%) and neutrophils (62%)] compared to control DP (p<0.01). Treatment with magnesium (Mg)-based DP 1h before TS reduced macrophages 21% (p<0.05); however, neither Mg nor sodium treatment reduced neutrophils. In an 11d exposure model, PUR118 reduced inflammation in prophylactic or therapeutic dosing regimes and markedly reduced the severity and incidence of peri-vascular and peri-bronchiolar inflammation, bronchiolitis, alveolitis, and pneumonitis by histopathological analysis. Conclusions: Ca-based DP reduced TS induced inflammation and improved lung pathology with equivalent efficacy to the p38 MAP kinase inhibitor. By targeting the infectious cause of AEs and baseline airway inflammation, inhaled Ca DP provides a novel multi-pronged approach for AE control.
Identification of a 13-kDa protein associated with the polyhydroxyalkanoic acid granules from Acinetobacter spp. (1995)

Proteins associated with poly+hydroxybutyrate (PHB) granules were purified from four Acinetobacter strains isolated from modified activated sludge treatment plants. Four predominant proteins of 64 kDa, 41 kDa, 38 kDa and 13 kDa were identified. N-terminal amino acid sequencing of the 64-kDa and I3-kDa proteins from Acinetobucter RA3849 identified these proteins as the products of the @UC,, and pIraP,, (formerly designated ORFl) genes, respectively. The expression of the 13-kDa protein (referred to as GA13) is shown to be required for the accumulation of large amounts of PHB in a recombinant Eschen'chiu coli strain.
Generation of hybrid human immunodeficiency virus by homologous recombination. (1989)

Human immunodeficiency virus (HIV) type 1, isolated from diverse sources, exhibits genomic diversity. The mechanisms by which the genomic diversity takes place in individuals exposed to multiple virus isolates is yet to be elucidated. Genetic variation, in general, might result from mutagenic events such as point mutations, rearrangements (insertions and deletions), and recombination. In an attempt to evaluate the process of genetic diversity, we designed experiments to analyze recombination between HIV DNAs by using DNA transfection in cell cultures. Here we report the successful recombination between truncated HIV proviral DNAs with an overlap homology of 53 base pairs that leads to the formation of viable hybrid virus. Recombination was also seen between exogenous DNA introduced into cells and homologous HIV sequences resident in the cells. These results indicate that recombination among various HIV isolates may play a significant role in the generation of genetic diversity of HIV. Further, the method used here enables the construction of hybrid HIV genomes to identify the viral determinants responsible for tropism, replication, and cytopathic effects.
THE HISTOLOGICAL DIAGNOSIS OF DERMATITIS HERPETIFORMIS, BULLOUS PEMPHKIOTD AND ERYTHEMA MULTIFORME. (1961)

Journal Article THE HISTOLOGICAL DIAGNOSIS OF DERMATITIS HERPETIFORMIS, BULLOUS PEMPHKIOTD AND ERYTHEMA MULTIFORME. Get access J. PIÉRARD, J. PIÉRARD Dermatological Department, State University, Ghent, Belgium Search for other works by this author on: Oxford Academic Google Scholar I. WHIMSTER I. WHIMSTER St. Thomas'Hospital, London, S.E.1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 73, Issue 7, 1 July 1961, Pages 253–266, https://doi.org/10.1111/j.1365-2133.1961.tb14442.x Published: 01 July 1961
Interaction of Immune and Connective Tissue Cells: I. The Effect of Lymphokines and Monokines on Fibroblast Growth (1990)

In order to determine if mononuclear cells may be secreting factors capable of modulating fibroblast growth, the in vitro proliferative response of fibroblasts to cytokines known to be secreted by mononuclear cells was measured, using both growth arrested and proliferating cells. Of the cytokines tested, which included interleukin-1 (IL-1), interleukin-2 (IL-2), interleukin-3 (IL-3), interleukin-4 (IL-4), interleukin-6 (IL-6), interferon-alpha (IFN-alpha), interferon-gamma (IFN-gamma), transforming growth factor-alpha (TGF-alpha), transforming growth factor-beta (TGF-beta), platelet derived growth factor (PDGF), and tumor necrosis factor-alpha (TNF-alpha), only TNF-alpha and PDGF had demonstrable growth factor activity. Neither IL-1 alpha nor beta showed any true growth factor activity but were able to enhance the replication of already proliferating cells. No inhibition of proliferation was noted by any of the cytokines with the exception of TNF-alpha and TGF-beta. TNF-alpha in doses greater than 500 ng/ml caused fibroblast death, probably by a prostaglandin related mechanism as fibroblasts remained viable, although non proliferative, when assayed in the presence of indomethacin, a known inhibitor of prostaglandin E2 (PGE2) synthesis. TGF-beta was inhibitory to proliferation at doses greater than 100 ng/ml, while fibroblasts remained viable. This effect was not influenced by indomethacin and hence is unlikely to be PGE2 related.
Synergistic antitumor activity of tumor-infiltrating lymphocytes, interleukin 2, and local tumor irradiation. Studies on the mechanism of action. (1990)

The adoptive transfer of tumor-infiltrating lymphocytes (TIL) with the concomitant administration of IL-2 has been shown to mediate the regression of established 6- and 14-d murine hepatic and pulmonary metastases. For successful immunotherapy with TIL, however, pretreatment with either cyclophosphamide (CP) or whole body irradiation (WBX) was required. The exact mechanism of CP and WBX augmentation of TIL antitumor activity remains unknown, but the elimination of Ts cells has been frequently invoked as an explanation. To address this possibility and to determine if local tumor irradiation (LTX) could synergize with TIL as well as WBX, we investigated the effect of LTX on the therapeutic efficacy of TIL and IL-2 in the treatment of multiple 7-d murine hepatic metastases. Experiments studying the treatment of a weakly immunogenic murine adenocarcinoma, MC-38, showed prolonged survival of mice treated with the combination of IL-2, TIL, and either LTX or WBX, compared with treatment with radiation alone or radiation plus IL-2 controls (p less than 0.0001). In addition, therapy with LTX and IL-2 prolonged survival, compared with LTX administration alone, whereas therapy with WBX combined with IL-2 did not alter survival. This augmentation of TIL-mediated antitumor activity was dependent on the dose of radiation used. To assess the possibility that tumor-associated Ts cells inhibit the function of adoptively transferred TIL in animals with 7-d metastatic tumor and are eliminated by WBX and LTX, we repeated the above experiments leaving some tumor unirradiated. Mice underwent either LTX or limited LTX, which included only the right side of the liver (LTX1/2). The number of right- and left-sided metastases were then individually counted. These studies showed that the reduction in the number of right-sided metastases was identical between the two groups and that the presence of left-sided tumor in the LTX1/2 group did not suppress the observed antitumor activity of TIL against irradiated tumor. Additional evidence against the elimination of suppressor cells as an important mechanism in radiation-induced augmentation of TIL antitumor activity was provided by experiments studying the effectiveness of TIL in thymectomized, lethally irradiated, and reconstituted B mice. Unless CP was administered before the adoptive transfer of TIL, therapy with IL-2 and TIL in these B mice was ineffective in the absence of demonstrable T lymphocytes.(ABSTRACT TRUNCATED AT 400 WORDS)
Cornea thickness and tear glucose levels in diabetes mellitus and normal persons. (1987)

The central corneal thickness as well as tear and blood glucose levels were significantly increased in diabetic patients as compared to normal persons. The tear glucose level of 9.0 mg/ld or less suggested good control of D.M.
Real-time Video Recommendation Exploration (2016)

Video recommendation has attracted growing attention in recent years. However, conventional techniques have limitations in real-time processing, accuracy or scalability for the large-scale video data. To address the deficiencies of current recommendation systems, we introduce some new techniques to provide real-time and accurate recommendations to users in the video recommendation system of Tencent Inc.. We develop a scalable online collaborative filtering algorithm based upon matrix factorization, with an adjustable updating strategy considering implicit feedback solution of different user actions. To select high-quality candidate videos for real-time top-N recommendation generation, we utilize additional factors like video type and time factor to compute similar videos. In addition, we propose the scalable implementation of our algorithm together with some optimizations to make the recommendations more efficient and accurate, including the demographic filtering and demographic training. To demonstrate the effectiveness and efficiency of our model, we conduct comprehensive experiments by collecting real data from Tencent Video. Furthermore, our video recommendation system is in production to provide recommendation services in Tencent Video, one of the largest video sites in China, and verifies its superiority in performance.
Decibel - The name for the transmission unit (1929)

In 1923 the “mile of standard cable” was replaced in the Bell System by a new unit for expressing telephone transmission efficiencies and levels. At that time, the generic term “transmission unit” was taken to designate this new unit, since it was considered desirable to defer the adoption of a more distinctive name until this unit had been given further consideration by others who would have use for a unit of this type. This new unit is defined by the statement that two amounts of power differ by one transmission unit when they are in the ratio of 1· <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> , and any two amounts of power differ by N transmission units when they are in the ratio of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N(.1)</sup> . In accordance with this, the number of transmission units corresponding to the ratio of any two powers is ten times the common logarithm of that ratio. [Originally reported in the Bell System Tech. Journal, January, 1929].
Rogue access point detection using temporal traffic characteristics (2005)

As the cost of IEEE 802.11 hardware continues to fall, the appeal of inserting unauthorized wireless access into enterprise networks grows. These rogue access points (AP) expose the enterprise network to a barrage of security vulnerabilities in that they are typically connected to a network port behind the firewall. Most of the current approaches to detecting rogue AP are rudimentary and are easily evaded by hackers. We propose the use of temporal traffic characteristics to detect rogue AP at a central location. This detection is independent of the wireless technology (IEEE 802.11a, 802.11b, or 802.11g), is scalable, does not possess the inefficiencies of the current solutions, and is independent of the signal range of the rogue AP.
INHIBITION OF K+ TRANSPORT AND CL- SECRETION IN T84 CELLS BY CLOTRIMAZOLE (1995)

Gastroenterology, Children's Hospital; Molecular Medicine and Renal Units, Beth Israel Hospital and Harvard Medical School, Boston.
Cell cycle synchronization and growth inhibition by 3-hydroxypyridin-4-one iron chelators in leukemia cell lines. (1992)

The effect of bidentate 3-hydroxypyridin-4-one (HPO) iron chelators on cell cycle arrest with subsequent cycle synchronization has been compared with that of the hexadentate desferrioxamine (DFO) in K562 and Daudi cells. The relationships between chelator concentration and inhibition of growth, DNA synthesis and ribonucleotide reductase, and phase of cell cycle arrest have also been explored. HPOs and DFO arrest the cell cycle in a dose-dependent manner causing a blockade at the G1-S border after 24 h at concentrations above 30 microM iron-binding equivalents. This is associated with reduced ribonucleotide reductase activity and concomitant cessation of DNA synthesis and growth. When the chelator is subsequently removed, HPO-treated cells synchronously cascade into S phase, unlike DFO-treated cells which resume cycling in a nonsynchronous manner. Chelator concentrations of approximately 25 microM and 3 microM iron-binding equivalents inhibited growth, DNA synthesis, and ribonucleotide reductase activity by 50% in K562 and Daudi cells, respectively. Concentrations less than 10 microM iron-binding equivalents inhibited K562 cell growth without an effect on DNA synthesis but with accumulation of cells in G2 and M phases. These results suggest that HPOs have advantages over DFO as cell cycle synchronization agents and may be useful adjuncts in cell cycle-specific treatment regimens.
Combined Theoretical and Experimental Studies of Nickel-Catalyzed Cross-Coupling of Methoxyarenes with Arylboronic Esters via C–O Bond Cleavage (2017)

Nickel(0)-catalyzed cross-coupling of methoxyarenes through C-O bond activation has been the subject of considerable research because of their favorable features compared with those of the cross-coupling of aryl halides, such as atom economy and efficiency. In 2008, we have reported nickel/PCy<sub>3</sub>-catalyzed cross-coupling of methoxyarenes with arylboronic esters in which the addition of a stoichiometric base such as CsF is essential for the reaction to proceed. Recently, we have also found that the scope of the substrate in the Suzuki-Miyaura-type cross-coupling of methoxyarenes can be greatly expanded by using 1,3-dicyclohexylimidazol-2-ylidene (ICy) as the ligand. Interestingly, a stoichiometric amount of external base is not required for the nickel/ICy-catalyzed cross-coupling. For the mechanism and origin of the effect of the external base to be elucidated, density functional theory calculations are conducted. In the nickel/PCy<sub>3</sub>-catalyzed reactions, the activation energy for the oxidative addition of the C(aryl)-OMe bond is too high to occur under the catalytic conditions. However, the oxidative addition process becomes energetically feasible when CsF and an arylboronic ester interact with a Ni(PCy<sub>3</sub>)<sub>2</sub>/methoxyarene fragment to form a quaternary complex. In the nickel/ICy-catalyzed reactions, the oxidative addition of the C(aryl)-OMe bond can proceed more easily without the aid of CsF because the nickel-ligand bonds are stronger and therefore stabilize the transition state. The subsequent transmetalation from an Ar-Ni-OMe intermediate is determined to proceed through a pathway with lower energies than those required for β-hydrogen elimination. The overall driving force of the reaction is the reductive elimination to form the carbon-carbon bond.
Blockchain-based chain of custody (2020)

Evidence is a tangible demonstrative artifact that proves a fact and shapes the investigation of various misconduct cases involving for instance corruption, misbehavior, or violation. It is imperative to maintain proper evidence management to guarantee the admissibility of an evidence in a court of law. Chain of custody forms the forensic link of evidence sequence of control, transfer, and analysis to preserve evidence's integrity and to prevent its contamination. Blockchain, a distributed tamper-resistant ledger can be leveraged to offer a decentralized secure digital evidence system. In this paper, we propose a secure chain of custody framework by utilizing the blockchain technology to store evidence metadata while the evidence is stored in a reliable storage medium. The framework is built on top of a private Ethereum blockchain to document every transmission from the moment the evidence is seized, thus ensuring that evidence can only be accessed or possessed by authorized parties. The framework is integrated with the digital evidence system where evidence is physically stored and locked using smart locks. To secure the sequence of evidence submission and retrieval, only an authorized party can possess the key to unlock the evidence. Our proposed framework offers a secure solution that maintains evidence integrity and admissibility among multiple stakeholders such as law enforcement agencies, lawyers, and forensic professionals. The research findings shed light on hidden opportunities for the efficient usage of blockchain in other realms beyond finance and cryptocurrencies.
Determination of carbon-13 labeled lactate in blood by gas chromatography/mass spectrometry (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of carbon-13 labeled lactate in blood by gas chromatography/mass spectrometryKou Yi. Tserng, Carol A. Gilfillan, and Satish C. KalhanCite this: Anal. Chem. 1984, 56, 3, 517–523Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://pubs.acs.org/doi/10.1021/ac00267a049https://doi.org/10.1021/ac00267a049research-articleACS PublicationsRequest reuse permissionsArticle Views367Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cylindrical-rectangular microstrip patch antenna for circular polarization (1993)

The circular polarization condition for a rectangular microstrip patch antenna on a thin cylindrical substrate is investigated. The theoretical study is based on the modal-expansion theory, which is valid for the thin-substrate case. Numerical results for the aspect ratio of the cylindrical-rectangular patch, the optimal feed point for minimum voltage standing wave ratio and the 3-dB bandwidth for circularly polarized radiation are analyzed. Effects of the curvature on the circular polarization condition are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase. (1986)

Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase was characterized, taking advantage of its induction by bacterial lipopolysaccharide. Our results demonstrated that in various tissues, N-formylkynurenine produced by the dioxygenase from tryptophan was rapidly hydrolyzed into kynurenine by a kynurenine formamidase, but it was not further metabolized. The localization in the liver and kidney of the kynurenine-metabolizing enzymes suggested that kynurenine thus formed was transported by the bloodstream to those two organs to be metabolized. In fact, the plasma kynurenine level increased in parallel with the induction of the dioxygenase by lipopolysaccharide, and kinetic analysis indicated that at the maximal induction of the enzyme there was a 3-fold increase in the kynurenine production. The major metabolic route of kynurenine was excretion in urine as xanthurenic acid. This increase in the kynurenine production was not explained by L-tryptophan 2,3-dioxygenase in the liver, because during the induction of indoleamine 2,3-dioxygenase, the hepatic enzyme level was substantially suppressed. These findings indicated that indoleamine 2,3-dioxygenase actively oxidized tryptophan in mice and that its induction resulted in an increase in tryptophan degradation.
Langdon's Historical and Religious Texts from the Temple Library of Nippur-Additions and Corrections (1940)

LANGDON'S volume, Historical and Religious Texts from the Temple Library of Nippur (= BE XXXI), consists largely of copies of Sumerian literary tablets and fragments located in the Museum of the Ancient Orient of Istanbul. As the scholars who have had occasion to make use of the volume will attest, the autographs contain an unusually large number of miscopies; if uncorrected, they will constitute an ever present source of error to the Assyriologists attempting to utilize their contents.' To remedy this situation, I devoted approximately two months of a prolonged stay in Istanbul to the collation of the originals in the Museum of the Ancient Orient.2 The following study will make available the results of this collation to Assyriologists.3
Metals as Catalysts during the Formation and Decomposition of Chlorinated Dioxins and Furans in Incineration Processes (1998)

Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are found on fly ash and in flue gas of municipal waste incinerators. Municipal waste incinerators seem to be the most important source for PCDDs and PCDFs emitted into the air during the last decades. PCDD/F formation takes place in the cooler zones (250 °C-450 °C) of a municipal waste incinerator, at the electrostatic precipitator. Copper is an important component of the fly ash that can catalyse the formation of PCDDs and PCDFs. Inhibition of the formation can be done by complexation of the metals (Cu) with EDTA or NTA.
Regularization with azimuth time‐shift correction (2003)

Irregular sampling can give problems for time-lapse seismic and imaging. Fourier regularization can be used to regularize the data, but this method does not take into account azimuth variations. For steeply dipping layers (in particular oblique dips), azimuth variations lead to timeshifts which can be significant, in particular for time-lapse surveys. In this paper a new method to correct for timeshifts due to azimuth variations is proposed. The correction for the time shifts is included in a 2D Radon regularization routine. The time-shifts are derived from an equation for the two-way time for a dipping layer in a homogeneous subsurface, but the method is also shown to correct for the time shifts for a point diffractor. For a synthetic time-lapse example, the azimuth time-shift correction leads to a strong improvement of the repeatability.