gebhart/patrepeval huggingface dataset:
The Biography Man (1977)

Your autobiography!" he said to them, standing gilded in the morning sun like a sparkling tournament trophy. "We will write your very own story! Take it from me. My company. . . ." His company, a back-Eastern somewhere wholesale publisher making books inexpensive like fine wines in the cellar. "The more who buy, the cheaper they come!" hailing them from the wagon all circus curlicue red yellow and golden with a steed stamping and whinnying on the dusty streets. The children first saw him arrive, an edge of town voyager in the dawn with leather straps, champing horse, all silver buckles, spokes and copper rims, pulling into the townsquare at day break and throwing the side open for everyone to gaze upon leather and goldtrim books. "Your own biography, your own life story!" printed on qual ity paper, inexpensive labor of speciality house "... can afford it because ..." because of pot-boilers which allow the philanthropist owner (everyone knows how crazy philanthropist millionaires are) to take huge trash-novel profits and send wagonmen through green little midwest towns to offer books, books, ". . . everyone loves books!" books about your very own life. Bound and goldtrimmed, don't forget that, printed and sent to you and see these here on display now, from Bainbridge over in Ohio, and Star City back in Indiana. Anyone have relatives in Star City? The crowd pushing closer to the wagon now like leaves blown against autumn trees, staring up at the traveling salesman, possible snake-oil man for the suspicious sheriff to run out of town. Up closer now, necks like marionettes, twisting to see the books. "Step up! Browse! Thumb through the life stories of your cousins!" Children dashing under the quiet nibbling horse's legs, chasing with gunsticks, and parents hollering to be quiet. The leading citizens, the mayor and city coun cilmen, all pinstripe and tophat and smile-vote formality, standing to one side on the way to the office for coffee and business. "Only ten dollars!" he shouts, "to leave a legacy for your children, your grandchildren, your great grandchildren!" This last striking that golden note in the hearts of all men who sire children, as every man wants to be immortal, every man has his pride. Now perking up, husbands turning and smiling and nodding at wives, a twinkle in their eyes, this sounds nice doesn't it now, a life story to give to 1 University of Iowa is collaborating with JSTOR to digitize, preserve, and extend access to The Iowa Review www.
Random walk in orthogonal space to achieve efficient free-energy simulation of complex systems (2008)

In the past few decades, many ingenious efforts have been made in the development of free-energy simulation methods. Because complex systems often undergo nontrivial structural transition during state switching, achieving efficient free-energy calculation can be challenging. As identified earlier, the "Hamiltonian" lagging, which reveals the fact that necessary structural relaxation falls behind the order parameter move, has been a primary problem for generally low free-energy simulation efficiency. Here, we propose an algorithm by achieving a random walk in both the order parameter space and its generalized force space; thereby, the order parameter move and the required conformational relaxation can be efficiently synchronized. As demonstrated in both the alchemical transition and the conformational transition, a leapfrog improvement in free-energy simulation efficiency can be obtained; for instance, (i) it allows us to solve a notoriously challenging problem: accurately predicting the pK(a) value of a buried titratable residue, Asp-66, in the interior of the V66E staphylococcal nuclease mutant, and (ii) it allows us to gain superior efficiency over the metadynamics algorithm.
A Feasibility Study on Hyperblock-based Aggressive Speculative Execution Model (2009)

Speculation execution model which executes sequential programs in parallel through speculation is an effective technique for making better use of growing on-chip resources and exploiting more instruction-level parallelism of applications. However, accompanied high communication overheads and roll-back penalties can not be neglected. This paper focuses on analyzing the feasibility of aggressive speculation execution model and finding an appropriate degree of "aggressiveness" under hyperblock-based execution model. We analyze the characteristic of control dependences and data dependences between adjacent hyperblocks, and propose a quantitative analysis method to detect data dependences on hyperblock-based execution model, and then evaluate the feasibility of aggressive speculative execution model on 8 applications from SPEC2K. Our experiments show most applications can get high prediction accuracy on control-flow from hyperblock-based prediction mechanisms, especially SPECFP. Furthermore, we analyze factors which impact expected prediction depth and find depth depends more on application than predictors.
Signaling strategies for dual-function radar communications: an overview (2016)

The last decade witnessed a growing demand on radio frequency that is driven by technological advances benefiting the end consumer but requiring new allocations of frequency bandwidths. Further, higher data rates for faster communications and wireless connections have called for an expanded share of existing frequency allocations. Concerns for spectrum congestion and frequency unavailability have spurred extensive research efforts on spectrum management and efficiency within the same type of service and have led to cognitive radio and cognitive radar. On the other hand, devising schemes for coexistence among different services have eased the competition for spectrum resources, especially for radar and wireless communication systems. Both systems have been recently given a common portion of the spectrum by the Federal Communications Commission.
SOME DERIVATIVES OF 10-ALKYLPHENOTHIAZINES (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSOME DERIVATIVES OF 10-ALKYLPHENOTHIAZINESHENRY GILMAN, ROBERT K. INGHAM, JOHN F. CHAMPAIGNE JR., JUSTIN W. DIEHL, and RALPH O. RANCKCite this: J. Org. Chem. 1954, 19, 4, 560–569Publication Date (Print):April 1, 1954Publication History Published online1 May 2002Published inissue 1 April 1954https://pubs.acs.org/doi/10.1021/jo01369a013https://doi.org/10.1021/jo01369a013research-articleACS PublicationsRequest reuse permissionsArticle Views184Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the solution of the tracking problem for non-linear systems with MPC (2005)

This paper presents a Model Predictive Control (MPC) algorithm for non-linear systems which solves the tracking problem for asymptotically constant references. Closed-loop stability of the equilibrium and asymptotic zero-error regulation are guaranteed. The performance of the method is discussed with the classical Continuous Stirred Tank Reactor (CSTR) control application. Keywords: Non-linear systemsNonlinear Model Predictive ControlDiscrete-time systemsTracking
Forskolin: From an Ayurvedic Remedy to a Modern Agent (1985)

Ancient Hindu Ayurvedic texts described the use of extracts from COLEUS species. An isolated diterpene from COLEUS FORSKOHLII, called forskolin, was demonstrated to be a hypotensive agent with spasmolytic, cardiotonic and platelet aggregation inhibitory activity. It has been shown to be a powerful activator of the enzyme adenylate cyclase in various tissues. Forskolin is thought to act on the catalytic subunit and also on the coupling mechanism of guanine regulatory sites (Ns and Ni) with the catalytic subunit. It is now clear that forskolin elicits physiological responses which have been shown to be cAMP-dependent.
Carbonylation (2000)

The article contains sections titled: 1. Introduction 2. Catalysts 2.1. Nickel Catalysts 2.2. Cobalt Catalysts 2.3. Palladium Catalysts 3. Carbonylation of Alkynes 3.1. Acrylic Acid from Acetylene 3.2. Other Carbonylation Reactions of Alkynes 4. Carbonylation of Alkenes 4.1. Monoalkenes 4.2. Substituted Alkenes 4.3. Polyenes 5. Carbonylation of Alcohols and Ethers 5.1. BASF Acetic Acid Process 5.2. Monsanto Acetic Acid Process 5.3. Carbonylation of Other Alcohols and Ethers 6. Carbonylation of Organic Halides 6.1. Aryl Halides 6.2. Alkyl Halides 6.3. Allyl Halides and Vinyl Halides 7. Other Carbonylation Reactions 7.1. Amines 7.2. Aromatic Nitro Compounds 7.3. Esters 7.4. Lactones and Aldehydes
Migration of Mouse 3T3 Fibroblasts in Response to a Serum Factor (1971)

A serum factor that promotes migration of (mouse) 3T3 fibroblast cells is shown to be distinct from the growth-promoting and cell-survival factors of serum. The factor promotes migration of cells from the edge of a wound in confluent 3T3 cells, but cell migration under these conditions does not lead to the initiation of DNA synthesis. Subsequent addition of serum initiates DNA synthesis in the migrating cells. The results establish that breaking contacts between quiescent 3T3 cells is not sufficient to initiate DNA synthesis. The DNA synthesis observed in migrating 3T3 cells in the typical "woundhealing" experiment presumably results because the migrating cells have an increased ability to use serum factors. Serum-factor requirements for "wound healing" in cultured 3T3 cells are discussed.
An optimizing prolog front-end to a relational query system (1984)

An optimizing translation mechanism for the dynamic interaction between a logic-based expert system written in PROLOG and a relational database accessible through SQL is presented. The mechanism makes use of an intermediate language that decomposes the optimization problem and makes the proposed approach target-language independent. It can either facilitate expert system - database interaction, e.g., when integrating expert systems into business systems, or augment existing databases with (external) deductive capabilities.
Supporting gifted students’ acquisition of relevant knowledge for solving math problems (1990)

Studies conducted in cognitive laboratories as well as in other settings suggest ways to facilitate people's abilities to use relevant knowledge in problem‐solving and decision making. Such activities help students understand the nature of the problems that various concepts and procedures were designed to solve, and hence enable them to understand the functional significance of new information. This study presented gifted 4th grade students with “real life” problem‐solving content, via videodisc technology, and then asked them to make valid suggestions about how to solve problems posed. Results illustrated that when children are instructed in problem‐solving strategies and then presented story information, they are more successful in solving posed problems than children who did not receive training.
Effect of sorbitol on salivary flow rate (2014)

Aim: The aim of the study is to investigate if the increased salivary flow rates obtained on chewing gum artificially sweetened with sorbitol is due to mastication or the active constituent of the gum i.e, sorbitol. Materials and Methods: The study consisted of 30 volunteers from Coorg Institute of Dental Sciences. The materials used in the study were sorbitol sweetened gums (SSGs), liquid sorbitol (LS) 70% concentration I.P from the company Gayatri Bio Organics Limited, paraffin wax (PW), and graduated beaker for measuring the saliva. The study was conducted in the morning hours from 9 am to 10 am by collecting un-stimulated saliva (US) from the subjects and by asking each of the subject to consume all the 3 constituents after each of which saliva was collected and measured using a calibrated beaker. Results: Pairwise comparison was done between US and saliva obtained after LS, SSGs, PW among the entire 30 subjects and also comparison between all the four groups using paired sample t-test. The pairwise comparison showed a significant difference between mean US and mean saliva obtained from SSGs and LS, but no significant difference was found between US and saliva obtained after chewing PW. The comparison between all four groups showed that there was no significant difference between LS and SSG P = 0.346, there was a significant difference between LS and PW P = 0.001 and also between SSG and paraffin P = 0.001. Conclusion: Sorbitol the active ingredient of artificially sweetened gums seems to be responsible for the increase in salivation rather than the act of mastication.
Structure Reassignment of the Fungal Metabolite TAEMC161 as the Phytotoxin Viridiol (2003)

Two-dimensional NMR analyses including HMBC, NOESY, and ROESY as well as 1D NOE experiments led to a reassignment of the structure of the recently identified Trichoderma hamatum metabolite TAEMC161 (1) as the previously known viridiol (2). In addition, GIAO-calculated (13)C NMR chemical shifts of 1 and 2 provided strong support for the revised structure.
Is Drift a Serious Alternative to Natural Selection as an Explanation of Complex Adaptive Traits? (2005)

‘There are known knowns; there are things we know we know. We also know there are known unknowns; that is to say we know there are some things we do not know. But there are also unknown unknowns—the ones we don’t know we don’t know.’ —Donald Rumsfeld, 2003, President George W. Bush’s Secretary of Defense, on the subject of the U.S. government’s failure to discover weapons of mass destruction in Iraq
Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the .sigma. receptor (1992)

By synthesizing and testing a part-structure, N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine (3), derived from our previously reported high affinity sigma receptor ligands (1S,2R)-(-)-N-[2-(3,4-dichlorophenyl)-ethyl]-N-methyl-2-(1- pyrrolidinyl)cyclohexylamine [(-)-2] and (+)-2, we have identified a novel class of superpotent (subnanomolar affinity) sigma ligands specific for the sigma receptor labeled by [3H]-(+)-3-PPP. When 3 was tested for its capacity to displace [3H]-(+)-3-PPP from guinea pig brain membranes, it exhibited a Ki of 0.34 nM, which is better than either of its parent compounds (-)-2 (Ki = 1.3 nM) and (+)-2 (Ki = 6.0 nM). Other compounds related to 3 such as N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-homopiperidinyl)ethy lamine (19) exhibited Ki = 0.17 nM [( 3H]-(+)-3-PPP). The determinants for high sigma receptor affinity of 3 were examined by manipulation of this structure in a number of different ways. The high efficacy of these compounds for the sigma receptor, their relative chemical simplicity and ease of synthesis, and their high degree of selective identifies N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine (3) and related compounds as a highly promising base for determination of the functional role of sigma receptors as well as the development of novel therapeutic agents.
Sequence-specific recognition of DNA minor groove by an NIR-fluorescence switch-on probe and its potential applications (2015)

In molecular biology, understanding the functional and structural aspects of DNA requires sequence-specific DNA binding probes. Especially, sequence-specific fluorescence probes offer the advantage of real-time monitoring of the conformational and structural reorganization of DNA in living cells. Herein, we designed a new class of D2A (one-donor-two-acceptor) near-infrared (NIR) fluorescence switch-on probe named quinone cyanine-dithiazole ( QCY-DT: ) based on the distinctive internal charge transfer (ICT) process for minor groove recognition of AT-rich DNA. Interestingly, QCY-DT: exhibited strong NIR-fluorescence enhancement in the presence of AT-rich DNA compared to GC-rich and single-stranded DNAs. We show sequence-specific minor groove recognition of QCY-DT: for DNA containing 5'-AATT-3' sequence over other variable (A/T)4 sequences and local nucleobase variation study around the 5'-X(AATT)Y-3' recognition sequence revealed that X = A and Y = T are the most preferable nucleobases. The live cell imaging studies confirmed mammalian cell permeability, low-toxicity and selective staining capacity of nuclear DNA without requiring RNase treatment. Further, Plasmodium falciparum with an AT-rich genome showed specific uptake with a reasonably low IC50 value (<4 µM). The ease of synthesis, large Stokes shift, sequence-specific DNA minor groove recognition with switch-on NIR-fluorescence, photostability and parasite staining with low IC50 make QCY-DT: a potential and commercially viable DNA probe.
Correlation between mannose-6-phosphate/IGFII receptor and cathepsin D RNA levels by in situ hybridization in benign and malignant mammary tumors. (1993)

We evaluated levels of mannose-6-phosphate/insulin growth factor-II receptor (M6P/IGFII-R) RNA in 37 breast cancer tumors by quantitative in situ hybridization using a computer-aided image analyzer and compared them to cathepsin D RNA and protein levels in the same tissues. Breast cancer cells expressed more cathepsin D and M6P/IGFII-R RNA than fibroblasts in the same tumors. We found a significant increase of cathepsin D RNA (P = 1 x 10(-5)) and M6P/IGFII-R RNA (P = 0.02) in breast cancer cells compared to epithelial cells of benign mastopathies. There was a positive correlation (r = 0.65; P = 1 x 10(-5)) between M6P/IGFII-R and cathepsin D RNA levels measured on serial sections. This contrasted with the inverse relationship of these 2 RNA species in breast cancer cell lines where estrogen down-regulates M6P/IGFII receptor RNA levels. Moreover, in vivo we found no correlation between the M6P/IGFII-R RNA level and menopausal or estrogen receptor status, suggesting that the in vivo regulation of M6P/IGFII-R RNA differs from its in vitro regulation in cell lines. The M6P/IGFII-R RNA level was not correlated with cathepsin D status, histological grade, and tumor size but was significantly higher in lymph node-positive tumors (P = 0.047). The M6P/IGFII-R could therefore be an additional parameter to predict aggressive breast cancers, complementing cathepsin D assays and other more classical prognostic parameters.
A Thermoelectrically Cooled Microtome Table and Knife (1964)

Thermoelectric cooling units (Frigistor thermoelements) have been used to replace CO2 gas and solid CO2 for microtome stage and knife cooling. These units consist of assemblies of series-connected thermoelements, functioning by the Peltier effect. Cooling is controlled by the direct current supply to the units. Current supply is from a double power pack giving 15 amp at 4.8 v for the knife cooling units, and 15 amp at 1 v for the stage. By varying the current flow, the optimum cutting temperature can be obtained and held indefinitely. An 8–couple Frigistor unit replaces the CO2 stage of a Lipshaw freezing microtome. The stage temperature may be lowered to –36 C in 40–60 sec and at the optimum cutting temperature, 5 μ serial sections of fixed frozen tissue are obtainable. Four 12–couple units are used to cool a 160 mm Jung plane wedge microtome knife fitted to a Reichert sledge microtome, with the stage cooled by one 8–couple unit. The knife temperature can be lowered to –20 C in 5 min; the stage in 1 min. The apparatus has been used to cut a variety of unfixed rat and mouse tissues. The optimum sectioning temperature for such unfixed liver, kidney, spleen, lymph glands, heart, testes, small intestine, pancreas, skin and lung was –20 to –22 C.
Both L- and D-isomers of allotrap 2702 prolong cardiac allograft survival in mice. (1996)

This study shows that administration of 2702.75-84 consisting of L- or D-amino acids will prolong graft survival in mice. In addition, the data suggest that the D2702 isomer is more potent than the L-isomer in vivo and may allow reduced dosage or frequency of administration.
Intervertebral disc cell- and hydrogel-supported and spontaneous intervertebral disc repair in nucleotomized sheep (2012)

Sheep experience spontaneous recovery from disc injury. The process of endogenous repair can be enhanced by means of hydrogel-supported cells.
Link delay inference based on simulated annealing constrained optimization method (2006)

With the rapid development of the network, it is necessary to know its internal characteristics, so to design, control and manage the network. At present, network measurement is mainly deployed to acquire internal characteristics of the network and identify network topology. Network tomography technology is one of the network measurement methods. Inference of network internal link characteristics is a very important to network tomography technology. On the basis of traditional methods used to infer link delay characteristics in network tomography, we propose a new method based on Simulated Annealing constrained optimization to improve the precision of inference of link delay cumulant generating functions by gathering the constrained information in network. The simulation results show that with measurement error, our constrained optimization method infers link delay more precisely than non-constrained ones do. (4 pages)
Identification of Biomarkers Modulated by the Rexinoid LGD1069 (Bexarotene) in Human Breast Cells Using Oligonucleotide Arrays (2006)

Retinoids have been found to be promising chemopreventive agents that play an important role in regulating cell growth, differentiation, and apoptosis. The action of retinoids is mediated by retinoid receptors (retinoic acid receptors and retinoid X receptors), which are nuclear transcription factors that, when bound to retinoids, regulate gene expression. LGD1069 is a highly selective RXR agonist that has reduced toxicity compared with retinoids. Our previous studies have shown that RXR-selective ligands (or "rexinoids"), including LGD1069, can inhibit the growth of normal and malignant breast cells and can suppress the development of breast cancer in transgenic mice. For the current study, we attempted to identify biomarkers of the chemopreventive effect of the RXR-selective retinoid LGD1069. In these experiments, we used Affymetrix microarrays to identify target genes that were modulated by LGD1069 in normal human breast cells. Affymetrix and dChip analysis identified more than 100 genes that were up-regulated or down-regulated by LGD1069 treatment. We then tested 16 of these genes in validation experiments using quantitative reverse transcription-PCR and Western blotting of independently prepared samples, and found that 15 of 16 genes were modulated in a similar manner in these validation experiments as in the microarray experiments. Genes found to be regulated include known retinoid-regulated genes, growth regulatory genes, transcription factors, and differentiation markers. We then showed that the expression of several of these rexinoid-regulated biomarkers is modulated in vivo in mammary glands from mice treated with LGD1069. These critical growth-regulating proteins will be promising targets of future agents for the prevention and treatment of breast cancer.