gebhart/patrepeval huggingface dataset:
Synthesis of New Receptors Highly Selective for Ammonium Cations (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis of New Receptors Highly Selective for Ammonium CationsSilvio Quici, Amedea Manfredi, and Marco ButtafavaView Author Information Centro CNR and Dipartimento di Chimica Organica e Industriale dell'Università, Via C. Golgi 19, 20133 Milano, Italy Cite this: J. Org. Chem. 1996, 61, 11, 3870–3873Publication Date (Web):May 31, 1996Publication History Received28 December 1995Published online31 May 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo952283xhttps://doi.org/10.1021/jo952283xbrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views200Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cations,Complexation,Ligands,Organic compounds,Receptors Get e-Alerts
Synthetic Fusion Peptides of Tick-Borne Encephalitis Virus as Models for Membrane Fusion (2009)

The fusion peptide of TBEV is a short segment of the envelope protein that mediates viral and host cell membrane fusion at acidic pH. Previous studies on the E protein have shown that mutations at L107 have an effect on fusogenic activity. Structural studies have also suggested that during the fusion process the E protein rearranges to form a trimer. In the present study, a number of short peptides were synthesized, and their structure/activity was examined: (1) monomers consisting of residues 93-113 of the wild-type E protein with Leu at position 107 (WT) and two mutants, namely, L107F and L107T; (2) a monomer consisting of residues 93-113 of the E protein with a C105A mutation (TFPmn); (3) a trimer consisting of three monomers described in (2), linked at the C-terminus via 1 Lys (TFPtr); (4) a monomer consisting of residues 93-113 of the E protein plus six additional Lys at the C-terminus; and (5) a trimer consisting of three monomers described in (3), linked via the side chain of the sixth lysine. The secondary structure content of all peptides was investigated using circular dichroism (CD). Approximately seven of the residues were in beta-strand conformation, in the presence of POPC/POPE/cholesterol. The structures did not depend on pH significantly. The fusogenicity of the peptides was measured by FRET and photon correlation spectroscopy. The data suggest that TFPtr is the most fusogenic at acidic pH and that the mutation from L107 to T reduces activity. Molecular dynamics simulations of WT, L107T, and L107F suggest that this reduction in activity may be related to the fact that the mutations disrupt trimer stability. Finally, tryptophan fluorescence experiments were used to localize the peptides in the membrane. It was found that WT, L107F, TFPmn, and TFPtr could penetrate better into the acyl chain region of the lipids than the other peptides tested. The implications of these results on the fusion mechanism of TBEV E protein will be presented.
EREL: an Entity Recognition and Linking algorithm (2017)

This paper introduces the EREL algorithm that integrates Entity Recognition, Co-reference Resolution (CR) and Disambiguation. The algorithm recognizes entity mentions as the longest name based on the name dictionary constructed from the Wikipedia data. The CR is integrated into the algorithm to improve the performance in processing short-form or abbreviated names. The algorithm employs a new approach in disambiguation entities using new features as entity-level context information and case-sensitive data about the mention in disambiguation. Tested on four benchmark data sets in the GERBIL framework, EREL outperforms the current Entity Linking methods. EREL achieves the micro f-score as 0.83 in both tasks Disambiguate to Wikipedia and Annotate to Wikipedia.
An Evaluation of Amalgamated Metallic Surfaces for Reducing Friction, Contact Resistance, and Wear in Electrical Contact Applications (1975)

It has been found that the mercury wetting of metallic surface is insufficient to reduce friction, whereas the amalgamation of certain metals to form a mercury rich solid layer at the surface significantly reduces friction, contact resistance, and wear. Also, the amalgamation of metal alloys results in considerably lower friction than the amalgamation of the constituent metals separately. Coefficients of friction for eleven amalgamated metals and four alloys are presented. Laser interference fringe surface topography, contact resistances, coefficients of friction during 1 km of wipe, the associated wear, and the effects of temperature on friction are reported for an amalgamated palladium-silver alloy.
Survivability and quality of service in mobile wireless networking (2003)

This paper focuses on two aspects of survivable, fault tolerant, mobile wireless networking: 1) dynamic IP affiliation and connectivity amidst router (base station) failures; and 2) quality of service based-mobility and routing. In both cases, we discuss the protocols developed, and we evaluate their performance using discrete event simulation. The processes and protocols developed represent enhancements to our previous work in base-station oriented tactical networks. We also discuss implications for scalability.
A Model of the Probability Distribution of the Signal-to-Noise Ratio Estimated from BER Measurements (2011)

For additive white Gaussian noise (AWGN) channels, first we show that the conditional probability distribution of the symbol error ratio (BER), in n transmitted symbols, can be modeled as lognormal in BPSK, QPSK and QAM transmission schemes, for a given average probability of symbol error p, and then we show that the channel signal-to-noise ratio (SNR), conditioned to p, can be modeled as a Gaussian random variable, as long as p>;>;1, n>;>;1, np≥1000. The theoretical results could be useful in assessing bounds to the estimated SNR in terrestrial, satellite or deep-space AWGN channels. Moreover, from the estimated SNR, it should be possible to estimate the fading due to slow tropospheric phenomena, such as rain, water vapor, oxygen attenuation.
New mode of plasma deposition in a capacitively coupled reactor (1984)

A new technique of radio frequency plasma-enhanced chemical vapor deposition is developed to achieve extremely high growth rates exceeding 40 Å/s. The two disk electrodes are surrounded by a stainless-steel mesh at ground potential, and an external variable reactance is connected between the substrate electrode and the ground. When the resonance condition in the circuit composed of the variable reactance and the substrate sheath capacitance is satisfied, a very high deposition rate is obtained as a result of dramatic change in the potential distribution between the two electrodes.
Nanoantennas for uncooled, double‐band, CMOS compatible, high‐speed infrared sensors (2004)

Abstract Nanoantennas for double‐band uncooled sensors are proposed for infrared focal plane arrays (FPA). Metal‐oxide‐metal tunnel diodes integrated with the nanoantennas are square‐law detectors for currents induced in the antennas by incident infrared radiation. The sensors that operate in the long‐wave infrared band are CMOS compatible and facilitate high‐speed processing exceeding 1000 frames per second. Double‐band sensors are proposed for each pixel of the FPA. The double‐band character of the sensor's responsivity is insured by the design of the antenna geometry. The frequency dependence of the insulator material is taken into account. Simulations of the proposed design are promising. Copyright © 2004 John Wiley & Sons, Ltd.
Experience with osseous implants for bone and biomaterials research. (1993)

A Cancellous Access Port (CAP) osseous implant for repeated sampling of cancellous tissue was developed and tested for experimental studies of bone, marrow, and materials biocompatibility. The CAP and associated methods were shown in a series of studies to allow the repeated biopsy of unstrained cancellous tissue with little morbidity and no mortality when used in baboons, rhesus, sheep, and horses. CAP infusion, material testing, and biopsy core assemblies were developed and tested for the administration and assessment of the effects of pharmaceuticals and biologics; the placement and retrieval of a biomaterial with the surrounding tissue; and studies of cancellous bone healing and remodeling.
Mediation of Unusually High Concentrations of 1,25-Dihydroxyvitamin D in Homozygous<i>klotho</i>Mutant Mice by Increased Expression of Renal 1α-Hydroxylase Gene (2002)

Homozygous klotho mutant (kl-/-) mice exhibit multiple phenotypes resembling human aging. To elucidate the molecular basis of these singular phenotypes, we focused on the mechanisms underlying increased serum concentrations of calcium and phosphorus in kl-/- mice. Serum concentrations of calcitonin and PTH of kl-/- mice were normally up- and down-regulated, respectively, in response to the high levels of calcium. On the other hand, despite the high concentrations of calcium, serum levels of 1,25-dihydroxyvitamin D [1,25-(OH)2D] in kl-/- mice were significantly higher than that of wild type (WT). The expression of 25-hydroxyvitamin D 1alpha-hydroxylase gene, the key enzyme of vitamin D metabolism, was also greatly enhanced in kidneys of kl-/- mice. Furthermore, the normal genetic responses to administered 1,25-(OH)2D3, such as down-regulation of the 25-hydroxyvitamin D 1alpha-hydroxylase gene and up-regulation of 24-hydroxylase and VDR genes, were apparently impaired in kl-/- mice. These findings suggest that this deterioration in the vitamin D endocrine system may result in many of the phenotypes in kl-/- mice through effects of increased levels of calcium and phosphorus and 1,25-(OH)2D. Klotho protein may participate in calcium and phosphorus homeostasis via the regulation of the 1,25-(OH)2D signaling pathway.
Using Supercalc4: The New Generation (1987)

The Integrated Pieces of SuperCalc 4 The SuperCalc 4 Spreadsheet Fundamentals Getting Data Into Your Spreadsheet Global Control of Your Spreadsheet Controlling Your Spreadsheet's Display Manipulating Your Spreadsheet Spreadsheet Input and Output Arithmetic, Statistical and Logical Functions Financial and Calendar Functions Indexing Functions and Tables Sorting Spreadsheets Integrated Spreadsheet Graphics Spreadsheet Data Management Exchanging SuperCalc 4 Spreadsheets with Other Systems SuperCalc 4 Macros SuperCalc 4 Advanced Applications Appendixes.
Development of membrane systems based on conducting polymers (1999)

We have developed a new generation of intelligent membrane systems using conducting polymers, utilising their unique electroactive properties. The chemical and physical properties of the film may be manipulated in-situ by application of electrical stimuli. This in turn allows modulation of the transport properties (even switching the transport off/on) and selectivity of the membrane. In addition, the versatility of synthesis of conducting polymers allows a wide range of chemistries and hence selectivities to be obtained to target particular applications, such as mineral recovery, protein separation, and salt rejection. Membranes can be fabricated as free standing films, composites, layer structures, or as thin films on conventional substrates. This paper reviews the development of these systems and highlights recent work on membranes with thin selective layers of conducting polymer.
The Transrapid Magnetic Levitation System: A Technical and Commercial Assessment (1992)

Magnetic levitation is the first truly new transportation technology in one hundred years and comes at a time when advances in transportation are sorely needed. The German Transrapid magnetic levitation train is the first commercially available system to use this technology. Based on technology that originated in the United States, the Transrapid system has been under development for approximately 15 years in Germany. During the last decade a number of serious proposals have been made for its use in the United States and Germany. However, to date, non have left the planning stage and all remain speculative at best. This is a function of the high level of risk associated with such a new technology, which has yet to prove itself in commercial operations, despite holding great promise for high levels of service.
Purple Sweet Potato Color Ameliorates Cognition Deficits and Attenuates Oxidative Damage and Inflammation in Aging Mouse Brain Induced by D‐Galactose (2009)

Purple sweet potato color (PSPC), a naturally occurring anthocyanin, has a powerful antioxidant activity in vitro and in vivo. This study explores whether PSPC has the neuroprotective effect on the aging mouse brain induced by D-galactose (D-gal). The mice administrated with PSPC (100 mg/kg.day, 4 weeks, from 9th week) via oral gavage showed significantly improved behavior performance in the open field and passive avoidance test compared with D-gal-treated mice (500 mg/kg.day, 8 weeks). We further investigate the mechanism involved in neuroprotective effects of PSPC on mouse brain. Interestingly, we found, PSPC decreased the expression level of glial fibrillary acidic protein (GFAP), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), inhibited nuclear translocation of nuclear factor-kappaB (NF-kappaB), increased the activity of copper/zinc superoxide dismutase (Cu/Zn-SOD) and catalase (CAT), and reduced the content of malondialdehyde (MDA), respectively. Our data suggested that PSPC attenuated D-gal-induced cognitive impairment partly via enhancing the antioxidant and anti-inflammatory capacity.
Roscovitine inhibits the proliferative activity of immortal and neoplastic human breast epithelial cells. (1998)

[2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylp urine] (roscovitine) is a potent and selective inhibitor of cyclin-dependent kinases cdc2 and cdk2. In this study, we evaluated the potential involvement of this novel cyclin-dependent kinase inhibitor in the proliferative activity of malignant and non-malignant human breast epithelial cells in vitro. Estrogen receptor-positive MCF-7 breast carcinoma cells, immortalized estrogen receptor-negative breast epithelial cells and highly malignant estrogen receptor-negative MDA-MB-231 breast epithelial cells, were incubated with different concentrations of roscovitine ranging from 1 to 40 micrograms/ml, and cell numbers were measured with the WST-1 colorimetric assay after 24, 48, 72, 96, 120, and 144 hours of treatment. Our results demonstrated that roscovitine inhibited the proliferation of human breast epithelial cells in a dose- and time-dependent manner. Roscovitine treatment decreased the number of viable cells and prevented the exponential growth of all the cell lines examined. The antiproliferative effect of this potent cdk inhibitor was independent of the estrogen receptor status of the cells. These data suggest that roscovitine is a potential antiproliferative drug for the treatment and/or prevention of both estrogen responsive and non-responsive breast cancers.
Power management modeling and optimal policy for IEEE 802.11 WLAN systems (2005)

Power saving is a critical issue for almost all kinds of portable devices as the lifetimes of wireless devices running on batteries are limited by their energy source capacity. Among portable devices, the IEEE 802.11 based products have become widespread in recent decades. In this paper, we proposed an optimal power management scheme which complies with the power saving mode (PS mode) deployed in IEEE 802.11 based networks to help the system consume power efficiently. A Markov decision process (MDP) approach is used to model the power tuning process. The listen interval of a mobile station is adjusted according to our proposed power management policy in order to optimize the power lifetime of a portable device while maintaining the link quality in terms of frame loss and delay. The numerical results are compared with various power management schemes including a noncontrolled scheme and fixed listen interval schemes. Simulations are conducted by network simulator, ns-2, to evaluate the performance under different traffic conditions.
Synchronization in digital communications networks (1991)

The general aspects of timing and synchronization in digital communications networks are reviewed. The properties of the links and nodes carrying and switching time-multiplexed digital signals determine the throughput and performance of a network. The continuity and integrity conditions for the digital information flow, where timing faults cause errors and loss of information, determine the requirements on accurate clock signal distribution. The dominant type of architecture for network synchronization is based on the master-slave hierarchy principle.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A transgenic mouse line for collecting ribosome-bound mRNA using the tetracycline transactivator system (2014)

Acquiring the gene expression profiles of specific neuronal cell-types is important for understanding their molecular identities. Genome-wide gene expression profiles of genetically defined cell-types can be acquired by collecting and sequencing mRNA that is bound to epitope-tagged ribosomes (TRAP; translating ribosome affinity purification). Here, we introduce a transgenic mouse model that combines the TRAP technique with the tetracycline transactivator (tTA) system by expressing EGFP-tagged ribosomal protein L10a (EGFP-L10a) under control of the tetracycline response element (tetO-TRAP). This allows both spatial control of EGFP-L10a expression through cell-type specific tTA expression, as well as temporal regulation by inhibiting transgene expression through the administration of doxycycline. We show that crossing tetO-TRAP mice with transgenic mice expressing tTA under the Camk2a promoter (Camk2a-tTA) results in offspring with cell-type specific expression of EGFP-L10a in CA1 pyramidal neurons and medium spiny neurons in the striatum. Co-immunoprecipitation confirmed that EGFP-L10a integrates into a functional ribosomal complex. In addition, collection of ribosome-bound mRNA from the hippocampus yielded the expected enrichment of genes expressed in CA1 pyramidal neurons, as well as a depletion of genes expressed in other hippocampal cell-types. Finally, we show that crossing tetO-TRAP mice with transgenic Fos-tTA mice enables the expression of EGFP-L10a in CA1 pyramidal neurons that are activated during a fear conditioning trial. The tetO-TRAP mouse can be combined with other tTA mouse lines to enable gene expression profiling of a variety of different cell-types.
On holographic imaging with long wavelength fields (1968)

Holograms recorded at microwave, acoustic, and other long wavelengths inherently produce image distortion when reconstruction is accomplished at visible wavelengths. A technique is presented for the reduction or elimination of this primary distortion.
The Streptococcus equi prophage-encoded protein SEQ2045 is a hyaluronan-specific hyaluronate lyase that is produced during equine infection (2009)

Streptococcus equi causes equine 'strangles'. Hyaluronate lyases, which degrade connective tissue hyaluronan and chondroitins, are thought to facilitate streptococcal invasion of the host. However, prophage-encoded hyaluronate lyases are hyaluronan-specific and are thought to be primarily involved in the degradation of the hyaluronan capsule of streptococci during bacteriophage infection. To understand the role of prophage-encoded hyaluronate lyases further, we have biochemically characterized such a hyaluronate lyase, SEQ2045 from S. equi, and have shown that it is produced during equine infection. Prophage-encoded hyaluronan-specific hyaluronate lyases may therefore play a more direct role in disease pathogenesis than previously thought.
Implementing Real-Time Update of Access Control Policies (2006)

Real-time update of access control policies, that is, updating policies while they are in effect and enforcing the changes immediately, is necessary for many security-critical applications. In this paper, we consider real-time update of access control policies that arise in a database system. Updating policy while they are in-effect can lead to potential security problems. In an earlier work, we presented an algorithm that not only prevents such security problems but also ensures correct execution of transactions. In the current work we extend that algorithm to handle addition and deletion of access control policies and provide the implementation details of the algorithm. We also describe properties of histories generated by this algorithm.
A Survey of Decision Fusion and Feature Fusion Strategies for Pattern Classification (2010)

AbstractFor any pattern classification task, an increase in data size, number of classes, dimension of the feature space, and interclass separability affect the performance of any classifier. A single classifier is generally unable to handle the wide variability and scalability of the data in any problem domain. Most modern techniques of pattern classification use a combination of classifiers and fuse the decisions provided by the same, often using only a selected set of appropriate features for the task. The problem of selection of a useful set of features and discarding the ones which do not provide class separability are addressed in feature selection and fusion tasks. This paper presents a review of the different techniques and algorithms used in decision fusion and feature fusion strategies, for the task of pattern classification. A survey of the prominent techniques used for decision fusion, feature selection, and fusion techniques has been discussed separately. The different techniques used for fus...