gebhart/patrepeval huggingface dataset:
Integration of wideband differential coupler with wideband differential MIMO antenna (2012)

In the modern wireless communication system, the antenna plays an important role for transmitting and receiving the electromagnetic waves. In general, antenna is a backbone in wireless communicatio ...
A detailed investigation of accessibilities around target sites of siRNAs and miRNAs (2011)

kiryu-h@k.u-tokyo.ac.jp
Binding properties of a cell adhesion molecule from neural tissue. (1982)

We have previously identified and purified a cell surface glycoprotein from retina and brain, called neural cell adhesion molecule or N-CAM, that appears to be involved in neural cell--cell adhesion, the fasciculation of neurites, and the formation of normal tissue patterns in the retina. The present studies reveal that artificial vesicles containing lipid and purified N-CAM bind to different cell types with a specificity similar to that of nerve cells. The same results were obtained with soluble N-CAM that had been briefly exposed to pH 3. In both cases the binding altered the rate of aggregation of neural cells and, like cell--cell adhesion, was inhibited by antibodies against N-CAM. The results support the proposal that N-CAM is a ligand in the formation of bonds between nerve cell membranes. Moreover, results of studies of vesicle--vesicle interactions and of N-CAM binding to cells coated with anti-(N-CAM) Fab' fragments were consistent with the idea that the N-CAM molecules on different cells may interact directly to form cell--cell bonds.
Food selection by <i>Dreissena polymorpha</i> Pallas (Mollusca: Bivalvia) (1982)

SUMMARY. The role of the selection systems in the mantle cavity and the stomach of Dreissena polymorpha was investigated by comparing the composition of particles in the plankton, the stomach and the mid‐gut. Both systems selected particles of 15–40 μm for food. The selection mechanism functioned more efficiently in the presence of simple algal mixtures than in the presence of lake plankton, but did not function at all in animals fed after 16 h starvation. The composition of successive pseudo‐faecal pellets differed. It is concluded that selection of different kinds of particle occurs in specific places in the mantle cavity. Cryptomonas spp. were highly preferred as food. Indications were found that not only does size‐selection occur, but also selection of a chemical nature.
A regression-based radar-mote system for people counting (2014)

People counting is key to a diverse set of sensing applications. In this paper, we design a mote-scale event-driven solution that uses a low-power pulsed radar to estimate the number of people within the ∼10m radial range of the radar. In contrast to extant solutions, most of which use computer vision, our solution is light-weight and private. It also better tolerates the presence of obstacles that partially or fully impair line of sight; this is achieved by accounting for “small” indirect radio reflections via joint time-frequency domain features. The counter itself is realized using Support Vector Regression; the regression map is learned from a medium sized dataset of 0–∼40 people in various indoor room settings. 10-fold cross validation of our counter yields a mean absolute error of 2.17 between the estimated count and the ground truth and a correlation coefficient of 0.97.We compare the performance of our solution with baseline counters.
Lysosomal Enzyme Abnormalities in Keratoconus (1989)

We studied the lysosomal enzyme activities in corneas obtained from 12 patients with keratoconus. Three acid hydrolases--acid phosphatase, acid esterase, and acid lipase--were demonstrated by histochemical staining methods in the epithelium, stroma, and endothelium of corneas with keratoconus and normal human corneas. Analyses by an image-processing system indicated that the epithelium, especially the basal epithelium, of corneas with keratoconus had significantly higher levels of acid phosphatase, acid esterase, and acid lipase than those in normal human controls. Such an abnormality was not seen in either scarred corneas or corneas obtained from patients with Fuchs' corneal dystrophy. Our finding is consistent with the hypothesis that tissue degradation processes may be abnormal in keratoconus. In addition, our data suggest that the corneal epithelium, as previously speculated, may also be involved in this corneal disease.
Hypoxia-induced expression of complement receptor type 1 (CR1, CD35) in human vascular endothelial cells (1999)

Reoxygenation of hypoxic human umbilical vein endothelial cells (HUVECs) increases protein expression of the complement regulators CD46 and CD55. As the receptor for C3b is known to be present on injured bovine endothelial cells, we investigated whether hypoxia or inflammatory mediators induce complement receptor type 1 (CR1; CD35) expression on HUVECs. CR1 protein expression increased 3.7 ± 0.6-fold as measured by ELISA on HUVECs following hypoxia (48 h, 1% O 2 ). Colocalization of CD35 and von Willebrand factor by confocal microscopy confirmed that CD35 was predominantly intracellular. Lipopolysaccharide or tumor necrosis factor-α also significantly increased HUVEC CR1 protein expression. Western blot analysis of neutrophil or hypoxic HUVEC lysates revealed a 221-kDa CR1 band under nonreducing conditions. RT-PCR of hypoxic HUVEC mRNA revealed a single band that, after sequencing, was identified as CD35. In situ hybridization of hypoxic HUVECs, but not normoxic HUVECs or fibroblasts, demonstrated increased CD35 mRNA. Hypoxic HUVECs bound immune complexes and acted as a cofactor for factor I-mediated cleavage of C3b. Thus hypoxia induces functional HUVEC CR1 expression.
A quantitative evaluation of cache types for high-performance computer systems (1993)

Parallel accesses to the table lookaside buffer (TLB) and cache array are crucial for high-performance computer systems, and the choice of cache types is one of the most important factors affecting cache performance. The authors classify caches according to both index and tag. Since both index and tag could be either virtual (V) or real (R), their classification results in four combinations or cache types. The real address caches with virtual tags for high-performance computer systems in this study are prediction-based, since index bins are generated from a small array and predictions could be false. As a result, they also discuss and evaluate real address MRU caches with real tags, and propose virtually indexed MRU caches with real tags. Each of the four cache types and MRU caches are discussed and evaluated using trace-driven simulation. The results show that a virtually indexed MRU cache with real tags is a good choice for high-performance computer systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Asymmetric Intermolecular Cobalt-Catalyzed Pauson–Khand Reaction Using a P-Stereogenic Bis-phosphane (2014)

The asymmetric intermolecular and catalytic Pauson-Khand reaction has remained an elusive goal since Khand and Pauson discovered this transformation. Using a novel family of P-stereogenic phosphanes, we developed the first catalytic system with useful levels of enantioselection for the reaction of norbornadiene and trimethylsilylacetylene. The results demonstrate that Co-bisphosphane systems are sufficiently reactive and that they lead to high selectivity in the intermolecular process.
Variation in barrier impairment and inflammation of human skin as determined by sodium lauryl sulphate penetration rate (2005)

We found that variation in the barrier impairment and inflammation of human skin depends on the SLS penetration rate, which was mainly determined by SC thickness.
New Steroid Acids from Antrodia cinnamomea, a Fungal Parasite of Cinnamomum micranthum (1995)

Three new steroids, zhankuic acids A [1], B [2], and C [3], were isolated from the fruiting bodies of Antrodia cinnamomea by bioassay-guided fractionation. The structures of these compounds were elucidated by chemical reactions and detailed analysis of their 1H- and 13C-nmr spectra. Biological studies revealed that 1 exhibited cytotoxic activity against P-388 murine leukemia cells and 2 showed weak anticholinergic and antiserotonergic activities.
Investigating the semantic interoperability of laboratory data exchanged using LOINC codes in three large institutions. (2011)

LOINC codes are seeing increased use in many organizations. In this study, we examined the barriers to semantic interoperability that still exist in electronic data exchange of laboratory results even when LOINC codes are being used as the observation identifiers. We analyzed semantic interoperability of laboratory data exchanged using LOINC codes in three large institutions. To simplify the analytic process, we divided the laboratory data into quantitative and non-quantitative tests. The analysis revealed many inconsistencies even when LOINC codes are used to exchange laboratory data. For quantitative tests, the most frequent problems were inconsistencies in the use of units of measure: variations in the strings used to represent units (unrecognized synonyms), use of units that result in different magnitudes of the numeric quantity, and missing units of measure. For non-quantitative tests, the most frequent problems were acronyms/synonyms, different classes of elements in enumerated lists, and the use of free text. Our findings highlight the limitations of interoperability in current laboratory reporting.
Agent-based telematic services and telecom applications (2001)

article Share on Agent-based telematic services and telecom applications Authors: Stefan Fricke Technical Univ. of Berlin, Berlin Technical Univ. of Berlin, BerlinView Profile , Karsten Bsufka Technical Univ. of Berlin, Berlin Technical Univ. of Berlin, BerlinView Profile , Jan Keiser Technical Univ. of Berlin, Berlin Technical Univ. of Berlin, BerlinView Profile , Torge Schmidt Technical Univ. of Berlin, Berlin Technical Univ. of Berlin, BerlinView Profile , Ralf Sesseler Technical Univ. of Berlin, Berlin Technical Univ. of Berlin, BerlinView Profile , Sahin Albayrak Technical Univ. of Berlin, Berlin Technical Univ. of Berlin, BerlinView Profile Authors Info & Claims Communications of the ACMVolume 44Issue 4April 2001 pp 43–48https://doi.org/10.1145/367211.367251Published:01 April 2001Publication History 55citation1,301DownloadsMetricsTotal Citations55Total Downloads1,301Last 12 Months36Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
An Experimental Evaluation of the Performance of Two Combination Pitot Pressure Probes (2009)

Experimental tests have been completed which recorded the ability of two combination steady state and high response time varying Pitot probe designs to accurately measure steady stagnation pressure at a single location in a flow field. Tests were conducted of double-barreled and coannular Prati probes in a 3.5 in. diameter free jet probe calibration facility from Mach 0.1 to 0.9. Geometric symmetry and pitch (-40 deg to 40 deg) and yaw (0 deg to 40 deg) angle actuation were used to fully evaluate the probes. These tests revealed that the double-barreled configuration induced error in its steady state measurement at zero incidence that increased consistently with jet Mach number to 1.1 percent at Mach 0.9. For all Mach numbers, the double-barreled probe nulled at a pitch angle of approximately 7.0 deg and provided inconsistent measurements when yawed. The double-barreled probe provided adequate measurements via both its steady state and high response tubes (within +/- 0.15 percent accuracy) over unacceptable ranges of biased pitch and inconsistent yaw angles which varied with Mach number. By comparison, the coannular probe provided accurate measurements (at zero incidence) for all jet Mach numbers as well as over a flow angularity range which varied from +/- 26.0 deg at Mach 0.3 deg to +/- 14.0 deg at Mach 0.9. Based on these results, the Prati probe is established as the preferred design. Further experimental tests are recommended to document the frequency response characteristics of the Prati probe.
Low frequency coefficient prediction for image coding (2002)

It has been shown that about 80% of the DC coefficients of a transformed image can be discarded at the encoder and then restored at the decoder using a DC coefficient restoration (DCCR) algorithm. This approach can improve the compression rate of JPEG by over 10% at low bit rates. We extend the DCCR algorithm not only to restore the DC coefficients but also to predict some of the (0, 1)th and (1, 0)th AC coefficients. The prediction thus allows these AC coefficients to be represented using less bits. Experimental results show that, almost in all cases, images coded using the proposed algorithm have higher PSNR and better visual quality than those coded using only the DCCR.
A Practical Approach To Statistical Log Analysis (1988)

The advantages of a statistical approach to log analysis have been extensively discussed. Statistical techniques use “inverse” methods to calculate formation parameters. These methods minimize the difference between actual tool responses and reconstructed theoretical tool responses. The use of statistical techniques has been limited, however, by the complexity of the mathematics and lengthy computer time required to minimize the non-linearequations. When computing lithology and porosity the tool response equations are usually linear or can be closely approximated by linear equations. The “inverse” problem can be solved directly without extensive iteration by using linear response equations. The approach described computes standard deviations which are used to normalize the response equations. Additional linear equations are added to the system of equations to insure linear independence as well as deal with necessary constraints. The system is then solved by a Modified GramSchmidt algorithm. A Maximum Liklihood Estimate (M.L.E.) of the standard deviation of the model can be calculated and used to evaluate the quality of the solution. This method not only solves the “overdetermined” case, but provides considerable help in solving the more common “underdetermined” case in which there is not enough information to solve for all the minerals present. The computation is faster and more flexible than conventional nonlinear methods. Previous papers have not supplied the details of the algorithms used to solve their statistical models. The algorithm needed for the solution of the linear model is not overly complex. One of the objectives of this paper is to provide the algorithm in sufficient detail to enable its incorporation into existing log analysis programs. This approach has become the standard method for computing lithology and porosity by Sun Exploration and Production Company world-wide. Extensive use has verified the effectiveness and flexibility of this approach.
Effect of patient motion on tomographic myocardial perfusion imaging. (1992)

We evaluated the effect of patient motion on inducing false-positive tomographic 201Tl myocardial perfusion studies. The effects of the angle of camera rotation at which movement occurs, the direction of movement and the distance of movement were studied. Movement was stimulated by shifting the raw data from normal motion-free 201Tl tomographic myocardial perfusion studies. The visual detectability of motion artifact was evaluated with receiver-operating characteristic curve analysis. The clinical importance of patient movement was determined by measuring the incidence of quantitative bull's-eye abnormalities induced by motion. Visual artifacts were more detectable and quantitative abnormalities more frequent as the distance of movement increased. Artifacts from 3.25 mm of movement were not visually detectable. Artifacts from 6.5 mm of movement were visually detectable, but were infrequently clinically important. Movement of 13 mm or greater frequently caused quantitative abnormalities. Quantitative abnormalities from axial movement were more frequent than artifacts from lateral movement. Quantitative abnormalities were more frequent when the movement occurred at the beginning or end. We conclude that when patients move during 201Tl tomographic myocardial perfusion imaging, the incidence and character of false-positive results depend on the angle of camera rotation at which the movement occurs, the direction of the movement and distance of the movement.
Incidental Prostate Cancer in Patients Undergoing Radical Cystoprostatectomy for Bladder Cancer (2008)

The objective of this work is to verify the incidence of incidental prostate adenocarcinoma in patients who underwent radical cystoprostatectomy for invasive bladder carcinoma. We have retrospectively reviewed patients who underwent radical cystoprostatectomy for infiltrative bladder tumors in period between 2003 and 2007 year, 94 men with bladder cancer underwent radical cystoprostatectomy at Urology Clinic-University of Sarajevo Clinics Centre. Mean age of patients was 67 years, with age limits ranging between 48 and 79 years. Pathohistological evaluation was used for all specimens from RCP. We found that 9,57% of cystoprostatectomy specimens in patients with bladder cancer also contained incidental prostate cancer. This result was much lower than overall mean frequency of incidentally detected prostate cancer in other series of cystoprostatectomy cases (range, 23%-68%). In conclusion we recommended digital rectal examination (DRE) and prostate-specific antigen (PSA) test as part of the bladder cancer work up and complete removal of the prostate at cystoprostatectomy to prevent residual prostate cancer.
The Tuberculosis Drug Discovery and Development Pipeline and Emerging Drug Targets (2015)

The recent accelerated approval for use in extensively drug-resistant and multidrug-resistant-tuberculosis (MDR-TB) of two first-in-class TB drugs, bedaquiline and delamanid, has reinvigorated the TB drug discovery and development field. However, although several promising clinical development programs are ongoing to evaluate new TB drugs and regimens, the number of novel series represented is few. The global early-development pipeline is also woefully thin. To have a chance of achieving the goal of better, shorter, safer TB drug regimens with utility against drug-sensitive and drug-resistant disease, a robust and diverse global TB drug discovery pipeline is key, including innovative approaches that make use of recently acquired knowledge on the biology of TB. Fortunately, drug discovery for TB has resurged in recent years, generating compounds with varying potential for progression into developable leads. In parallel, advances have been made in understanding TB pathogenesis. It is now possible to apply the lessons learned from recent TB hit generation efforts and newly validated TB drug targets to generate the next wave of TB drug leads. Use of currently underexploited sources of chemical matter and lead-optimization strategies may also improve the efficiency of future TB drug discovery. Novel TB drug regimens with shorter treatment durations must target all subpopulations of Mycobacterium tuberculosis existing in an infection, including those responsible for the protracted TB treatment duration. This review summarizes the current TB drug development pipeline and proposes strategies for generating improved hits and leads in the discovery phase that could help achieve this goal.
On Textual Analysis and Machine Learning for Cyberstalking Detection (2016)

Cyber security has become a major concern for users and businesses alike. Cyberstalking and harassment have been identified as a growing anti-social problem. Besides detecting cyberstalking and harassment, there is the need to gather digital evidence, often by the victim. To this end, we provide an overview of and discuss relevant technological means, in particular coming from text analytics as well as machine learning, that are capable to address the above challenges. We present a framework for the detection of text-based cyberstalking and the role and challenges of some core techniques such as author identification, text classification and personalisation. We then discuss PAN, a network and evaluation initiative that focusses on digital text forensics, in particular author identification.
Deep Learning Enables High-Throughput Analysis of Particle-Aggregation-Based Biosensors Imaged Using Holography (2018)

Aggregation-based assays, using micro- and nanoparticles have been widely accepted as an efficient and cost-effective biosensing tool, particularly in microbiology, where particle clustering events are used as a metric to infer the presence of a specific target analyte and quantify its concentration. Here, we present a sensitive and automated readout method for aggregation-based assays using a wide-field lens-free on-chip microscope, with the ability to rapidly analyze and quantify microscopic particle aggregation events in 3D, using deep learning-based holographic image reconstruction. In this method, the computation time for hologram reconstruction and particle autofocusing steps remains constant, regardless of the number of particles/clusters within the 3D sample volume, which provides a major throughput advantage, brought by deep learning-based image reconstruction. As a proof of concept, we demonstrate rapid detection of herpes simplex virus (HSV) by monitoring the clustering of antibody-coated microparticles, achieving a detection limit of ∼5 viral copies/μL (i.e., ∼25 copies/test).
Design of Organo-Peptides As Bipartite PCSK9 Antagonists (2020)

Proprotein convertase subtilisin/kexin 9 (PCSK9) has become an important therapeutic target for lipid lowering, since it regulates low-density lipoprotein cholesterol (LDL-c) levels by binding to liver LDL receptors (LDLR) and effecting their intracellular degradation. However, the development of small molecule inhibitors is hampered by the lack of attractive PCSK9 target sites. We recently discovered helical peptides that are able to bind to a cryptic groove site on PCSK9, which is situated in proximity to the main LDLR binding site. Here, we designed potent bipartite PCSK9 inhibitors by appending organic moieties to a helical groove-binding peptide to reach a hydrophobic pocket in the proximal LDLR binding region. The ultimately designed 1-amino-4-phenylcyclohexane-1-carbonyl extension improved the peptide affinity by >100-fold, yielding organo-peptide antagonists that potently inhibited PCSK9 binding to LDLR and preserved cellular LDLR. These new bipartite antagonists have reduced mass and improved potency compared to the first-generation peptide antagonists, further validating the PCSK9 groove as a viable therapeutic target site.
Acylated chitooligomers are molecular signals that mediate the symbiotic interactions between nitrogen-fixing bacteria and their host plants (1998)

Abstract