gebhart/patrepeval huggingface dataset:
DESIGN, ANALYSIS AND TEST CONCEPT FOR PROTOTYPE CRYOLINE OF ITER (2008)

The ITER cryo-distribution and cryoline is a part of the in-kind supply for India. The design of the systems is in progress. The topology of torus and neutral beam cryoline is defined as six process pipes along with thermal shield at 80 K and outer vacuum jacket. In order to develop confidence in the concept and to establish the high level of engineering and manufacturing technology, a prototype testing has been proposed. The prototype test will be carried out on 1:1 model in terms of dimension. However, the mass flow rate of the supercritical helium at 4.5 K and gaseous helium at 80 K will be on a 1:10 scale. The prototype cryoline has been designed and analyzed for thermal, structural and hydraulic parameters. The objective of this prototype test is to verify mechanical behavior due to thermal stress and pressure force, thermal and hydraulic performances. The concept of test facility has been realized along with the Piping and Instrumentation (P & I) diagram, instrumentation, controls, data acquisition, 80 K helium generation system along with supply and return valve boxes and interfacing hardware. The design concept, methodology for analysis and results, as well as the test facility have been discussed.
Concerted Regulation of Cell Dynamics by BNIP-2 and Cdc42GAP Homology/Sec14p-like, Proline-rich, and GTPase-activating Protein Domains of a Novel Rho GTPase-activating Protein, BPGAP1 (2003)

RhoA, Cdc42, and Rac1 are small GTPases that regulate cytoskeletal reorganization leading to changes in cell morphology and cell motility. Their signaling pathways are activated by guanine nucleotide exchange factors and inactivated by GTPase-activating proteins (GAPs). We have identified a novel RhoGAP, BPGAP1 (for BNIP-2 and Cdc42GAP Homology (BCH) domain-containing, Proline-rich and Cdc42GAP-like protein subtype-1), that is ubiquitously expressed and shares 54% sequence identity to Cdc42GAP/p50RhoGAP. BP-GAP1 selectively enhanced RhoA GTPase activity in vivo although it also interacted strongly with Cdc42 and Rac1. "Pull-down" and co-immunoprecipitation studies indicated that it formed homophilic or heterophilic complexes with other BCH domain-containing proteins. Fluorescence studies of epitope-tagged BPGAP1 revealed that it induced pseudopodia and increased migration of MCF7 cells. Formation of pseudopodia required its BCH and GAP domains but not the proline-rich region, and was differentially inhibited by coexpression of the constitutively active mutant of RhoA, or dominant negative mutants of Cdc42 and Rac1. However, the mutant without the proline-rich region failed to confer any increase in cell migration despite the induction of pseudopodia. Our findings provide evidence that cell morphology changes and migration are coordinated via multiple domains in BPGAP1 and present a novel mode of regulation for cell dynamics by a RhoGAP protein.
Waveguide optical switch for 8:1 standby system of optical line terminals (2002)

Summary form only given. Summary form only given. To reduce the cost of the optical access network without sacrificing system reliability, instead of using a fully duplex standby system, we are planning to allow a single reserve to be shared among several pieces of equipment. We show the planned configuration of a standby system to share a reserved optical subscriber unit (OSU) in an optical line terminal (OLT) for NTT's passive double star (PDS) optical access network. This solution, however, requires an optical switch to have high reliability and low insertion loss and be independent of both wavelength and polarization, inexpensive and self-latching. None of the switches proposed so far meet all these requirements. In this paper we propose an 8:1 optical switch that is suitable for sharing a reserve OSU to reduce the standby cost. Our switch is an intersecting waveguide switch, whose operating principle is based on thermo-capillarity.
Vision Strategies for Robotic Manipulation of Natural Objects (2009)

This paper describes a vision guided robotic platform that will be used for the handling of natural products in a multi-layer stack that is typical in a bin situation. It is designed to automatically recognise non-rigid objects, to estimate their pose, and to select suitable picking points using depth information from a 3D camera. We adopted a novel approach by using a topographical method to segment the objects and then with elevation contours to build volumetric data for each object. When the periphery for each object is established, we introduced strategies by which decisions will be made for task planning. These strategies identify the appropriate object to pick and the optimum picking position. Results of the experimental trials demonstrate the robustness of this approach for specific types of natural products. 1
Construction of interactive movie system for multi-person participation (2002)

Interactive movies have emerged as a new type of media that implements interaction capabilities into movies. In interactive movies, people enter cyberspace and enjoy the development of a story by interacting with characters in the story. We first explain the concept of interactive movies and briefly describe the prototype system we have developed. We then describe the construction of a second system, which we are currently developing, as well as several improvements incorporated in it.
Lipopeptides: from self-assembly to bioactivity (2015)

This Feature Article discusses several classes of lipopeptide with important biomedical applications as antimicrobial and antifungal agents, in immune therapies and in personal care applications among others. Two main classes of lipopeptide are considered: (i) bacterially-expressed lipopeptides with a cyclic peptide headgroup and (ii) linear lipopeptides (with one or more lipid chains) based on bio-derived and bio-inspired amino acid sequences with current clinical applications. The applications are briefly summarized, and the biophysical characterization of the molecules is reviewed, with a particular focus on self-assembly. For several of these types of biomolecule, the formation of micelles above a critical micelle concentration has been observed while others form bilayer structures, depending on conditions of pH and temperature. As yet, there are few studies on the possible relationship between self-assembly into structures such as micelles and bioactivity of this class of molecule although this is likely to attract further attention.
Database cost analysis (1977)

A top-down approach is proposed for cost analysis for database and information system design. General principles are given which allow the analyst either to estimate rapidly the costs of a wide variety of alternatives or to investigate fewer possibilities in great detail. Techniques are developed which can be used at any level of the iterative design process - at the early stages or at the detailed phase of specific design. The paper applies the methods to the basic categories of file cost at the simpler levels of analysis and refers to the literature for more sophisticated analyses, which can be done within the framework provided here. Among the specific results developed are: the extension of a widely-used hit ratio formula to non-uniform usage distribution; the introduction of the "distribution of depths" for serial accesses; a general activity analysis and a volatility analysis for indexed sequential files.
IM, Not IP (Information Pollution) (2003)

Respected technology commentators say that they now prefer instant messaging (IM) over e-mail as their medium of choice for computer-mediated communication. The main reasons are that e-mail has become an overloaded channel for readers and that you can’t be sure to get a timely response from the recipients of your e-mail.
Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation (2012)

During states of low carbohydrate intake, mammalian ketone body metabolism transfers energy substrates originally derived from fatty acyl chains within the liver to extrahepatic organs. We previously demonstrated that the mitochondrial enzyme coenzyme A (CoA) transferase [succinyl-CoA:3-oxoacid CoA transferase (SCOT), encoded by nuclear Oxct1] is required for oxidation of ketone bodies and that germline SCOT-knockout (KO) mice die within 48 h of birth because of hyperketonemic hypoglycemia. Here, we use novel transgenic and tissue-specific SCOT-KO mice to demonstrate that ketone bodies do not serve an obligate energetic role within highly ketolytic tissues during the ketogenic neonatal period or during starvation in the adult. Although transgene-mediated restoration of myocardial CoA transferase in germline SCOT-KO mice is insufficient to prevent lethal hyperketonemic hypoglycemia in the neonatal period, mice lacking CoA transferase selectively within neurons, cardiomyocytes, or skeletal myocytes are all viable as neonates. Like germline SCOT-KO neonatal mice, neonatal mice with neuronal CoA transferase deficiency exhibit increased cerebral glycolysis and glucose oxidation, and, while these neonatal mice exhibit modest hyperketonemia, they do not develop hypoglycemia. As adults, tissue-specific SCOT-KO mice tolerate starvation, exhibiting only modestly increased hyperketonemia. Finally, metabolic analysis of adult germline Oxct1(+/-) mice demonstrates that global diminution of ketone body oxidation yields hyperketonemia, but hypoglycemia emerges only during a protracted state of low carbohydrate intake. Together, these data suggest that, at the tissue level, ketone bodies are not a required energy substrate in the newborn period or during starvation, but rather that integrated ketone body metabolism mediates adaptation to ketogenic nutrient states.
Aircraft Weight and Center of Mass Estimation System (2016)

<div class="section abstract"><div class="htmlview paragraph">Aircraft weight and center of mass are two critical design and operational parameters that have to be within a design envelope to ensure a safe and efficient operation of aircraft. Previous efforts to accurately determine aircraft weight and center of mass before takeoff using landing gear shock strut pressures have failed due to the distortion of measured pressures by shock strut seal friction. Currently, aircraft loading process is controlled with loading sheets and passenger/cargo weight estimation as there are no online measurement systems that can accurately and efficiently estimate aircraft weight and determine the center of mass location before takeoff. However, errors in loading sheets, shifting cargo and errors in weight estimation could lead to incorrect loading of aircraft and, consequently, increase the risk of accidents, particularly in cargo flights. In this paper, an online weight measurement system that can determine an aircraft weight and its center of mass before takeoff is presented. The aircraft weight estimation system is comprised of a few sensing elements, installed on aircraft landing gear shock struts and a weight estimation algorithm that may be executed when aircraft is in motion (forward or backward) while on the ground before takeoff. The algorithm uses mathematical functions to filter sensor measurements and calculate aircraft weight and its center of mass using sensor online readings. A set of data associated with an aircraft flight test is used to simulate the algorithm implementation in offline mode. Simulation results have shown that aircraft weight and center of mass location can be estimated with an acceptable accuracy.</div></div>
A broadly tunable synthesis of linear α-olefins (2017)

The catalytic synthesis of linear α-olefins from ethylene is a technologically highly important reaction. A synthesis concept allowing the formation of selective products and various linear α-olefin product distributions with one catalyst system is highly desirable. Here, we describe a trimetallic catalyst system (Y-Al-Ni) consisting of a rare earth metal polymerization catalyst which can mediate coordinative chain transfer to triethylaluminum combined with a simultaneously operating nickel β-hydride elimination/transfer catalyst. This nickel catalyst displaces the grown alkyl chains forming linear α-olefins and recycles the aluminum-based chain transfer agent. With one catalyst system, we can synthesize product spectra ranging from selective 1-butene formation to α-olefin distributions centered at 850 gmol<sup>-1</sup> with a low polydispersity. The key to this highly flexible linear α-olefin synthesis is the easy tuning of the rates of the Y and Ni catalysis independently of each other. The reaction is substoichiometric or formally catalytic regarding the chain transfer agent.
Hydroxy-cruciforms (2007)

The synthesis of hydroxy-cruciforms 7 and 8 and their dramatically varying photophysical properties upon exposure to amines are reported.
Preparation of Fv fragment from the mouse myeloma XRPC-25 immunoglobulin possessing antidinitrophenyl activity (1976)

<P>Abstract copyright UK Data Service and data collection copyright owner.</P>This machine-readable version of John Williams' <i>Digest of Welsh Historical Statistics</i> is the result of a collaboration between the Statistical Directorate of the National Assembly for Wales, the History Data Service and the Centre for Data Digitisation and Analysis at Queen's University Belfast.<br> John Williams' <i>Digest of Welsh Historical Statistics</i> is intended to provide a service for those working on the history of modern Wales. It arises from a belief that the quantitative element is a necessary and important part of the historical record; from an awareness that it was an aspect that was particularly inaccessible for scholars of Welsh history; and from a conviction that some encouragement in the use of quantitative material was necessary. It is modelled on the two volumes dedicated to British historical statistics: Mitchell, B.R. and Deane, P. (1962) <i>Abstract of British historical statistics</i> and Mitchell, B.R. and Jones, H.G. (1971) <i>Second abstract of British historical statistics</i>.
Reducing effects of garlic constituents on DNA adduct formation in human lymphocytes<i>in vitro</i> (1997)

A water extract of raw garlic (RGE) and two organosulfur compounds, diallyl sulfide and S-allylcysteine (SAC), were evaluated for their relative effectiveness in reducing benzo[a]pyrene (BaP)-DNA adduct formation in stimulated human peripheral blood lymphocytes in vitro. In replicate experiments, RGE significantly inhibited BaP-DNA adduct formation at concentrations of 0.001, 0.01, and 0.1 mg/ml. SAC also significantly decreased BaP-DNA adduct formation at concentrations of 0.01 and 0.1 mg/ml. For diallyl sulfide, no significant reduction in BaP-DNA adduct formation was found. BaP-DNA adduct formation was not associated with cell viability or proliferation of peripheral blood lymphocytes after the various treatments. No clear scavenging activity was detected for the garlic constituents. Aryl hydrocarbon hydroxylase activity was not decreased, nor was formation of sulfate and glucuronide conjugates of 3-hydroxy-BaP increased in the presence of RGE and SAC, indicating that increased glutathione S-transferase activity or a more efficient repair of BaP-DNA adducts may explain the observed effects. In addition, reactive oxygen species-induced 8-oxodeoxyguanosine in DNA was reduced in the presence of SAC. It is concluded that raw garlic and SAC may be useful in the prevention of BaP-associated tumorigenesis and that further evaluation of their preventive potential in humans at risk appears feasible.
Regulation of the expression level of transcription factor XylS reveals new functional insight into its induction mechanism at the Pmpromoter (2013)

According to our proposed model, which is in agreement with current knowledge, the regulator, XylS, can exist in three states: monomers, dimers, and aggregates. Only the dimers are active and able to induce expression from Pm. Their maximum intracellular concentration and the corresponding output from Pm are limited by the concentration-dependent conversion into inactive aggregates. Maximization of the induction ratio at Pm can be obtained by expression of XylS at the level where aggregation occurs, which might be exploited for recombinant gene expression. The results described here also indicate that there might exist variants of XylS which can exist at higher active dimer concentrations and thus lead to increased expression levels from Pm.
Kranbahnen (1985)

Mittels aufgelegter Kranschienen dienen Kranbahnträger im Freien oder in Hallen als Fahrbahn für Laufkrane. Sie sind nicht vorwiegend ruhend belastete Bauteile und werden als einfache Balken oder auch als Durchlauf- und Gelenkträger ausgebildet. Ihre Auflagerung erfolgt auf Kranbahnstützen (183.1) oder Konsole n an den Hallenrahmen (25.2 a); Aufhängen an der Dachkonstruktion ergibt eine stützenfreie Halle, aber schwere Binder (187.1). Quer zur Fahrtrichtung werden die Kranbahnstützen im Fundament eingespannt; da sie in Längsrichtung in der Regel als Pendelstützen wirken, macht ein unterhalb der Kranbahnträger lotrecht zwischen 2 Stützen eingebauter Bremsverband die Kranbahnanlage standsicher und führt die in Längsrichtung der Kranbahn wirkenden Kräfte hinunter in das Fundament. — Liegt der Boden des Kransteuerstandes mehr als 5 m über Flur, muß oberhalb, neben oder unterhalb der Kranbahn auf ganzer Länge ein Fahrbahnlaufsteg vorhanden sein, der über mindestens eine Treppe zugänglich ist (s. Abschn. 8.1).
FSH influences follicle viability, oestradiol biosynthesis and ovulation rate in Romney ewes (1985)

Injection of steroid-free bovine follicular fluid (bFF; 2 X 5 ml s.c. 12 h apart) into anoestrous ewes lowered plasma FSH concentrations by 70% and after 24 h had significantly (P less than 0.01) reduced the number of non-atretic follicles (greater than or equal to 1 mm diam.) without influencing the total number of follicles (greater than 1 mm diam.) compared to untreated controls. Hourly injections of FSH (10 micrograms i.v. NIH-FSH-S12) for 24 h did not influence the number of non-atretic follicles but did negate the inhibitory effects of bFF on follicular viability. Hourly injections of FSH (50 micrograms i.v., NIH-FSH-S12) + bFF treatment for 24 h significantly increased the total number of non-atretic follicles, and particularly the number of medium to large non-atretic follicles (greater than 3 mm diam.) compared to the untreated controls (both P less than 0.01). The 10 micrograms FSH regimen (without bFF) significantly increased aromatase activity in granulosa cells from large (greater than or equal to 5 mm diam.; P less than 0.01) but not medium (3-4.5 mm diam.) or small (1-2.5 mm diam.) follicles compared to controls. The 10 micrograms FSH + bFF regimen had no effect on granulosa-cell aromatase activity compared to the controls. However, the 50 micrograms FSH plus bFF regimen increased the aromatase activity of granulosa cells from large, medium and small non-atretic follicles 2.6-, 8.3- and greater than or equal to 11-fold respectively compared to that in the control cells. Ewes (N = 11) that ovulated 2 follicles had significantly higher plasma FSH concentrations from 48 to 24 h and 24 to 0 h before the onset of a cloprostenol-induced follicular phase (both P less than 0.01) than in the ewes (N = 12) that subsequently ovulated one follicle. Hourly FSH treatment (1.6 micrograms i.v., NIAMDD-FSH-S15) for 24 h but not for any 6 h intervals between 48 and 24 h or 24 and 0 h before a cloprostenol-induced luteolysis also resulted in significant increases (P less than 0.05) in the number of ewes with 2 ovulations.(ABSTRACT TRUNCATED AT 400 WORDS)
Treatment of epidemic Kaposi's sarcoma with etoposide or a combination of doxorubicin, bleomycin, and vinblastine. (1984)

An epidemic of disseminated Kaposi's sarcoma in male homosexuals has recently been described. Forty-one evaluable patients with epidemic Kaposi's sarcoma were treated with etoposide. The majority of these patients had early stage disease, no prior opportunistic infections, and no prior therapy. Twelve patients (30%) achieved complete remission, 19 (46%) partial remission, and ten (24%) no response. With follow-up time to 31 months, the median response duration is nine months. The median survival of patients with complete and partial remissions has not been reached. A combination of doxorubicin (Adriamycin, Adria Laboratories, Columbus, Ohio), bleomycin, and vinblastine (ABV) was used in 31 evaluable patients with epidemic Kaposi's sarcoma. The majority of these patients had late stage disease, prior opportunistic infections, or had failed prior treatment. Seven patients (23%) achieved complete remission, 19 (61%) partial remission, and five (61%) no response. With follow-up time to 24 months, the median response duration is eight months. The projected median survival for all patients treated with ABV is nine months. Both regimens were well tolerated, with an overall response rate of 76% for etoposide and 84% for ABV. However, while successfully treating the Kaposi's sarcoma, the underlying immune deficiency in these patients has persisted. Future treatments of Kaposi's sarcoma will need to focus on reversing the underlying immune incompetence as well as controlling the malignant manifestations of Kaposi's sarcoma arising in relation to the acquired immune deficiency syndrome.
Preparation and Properties of Yttrium‐Silicon‐Aluminum Oxynitride Glasses (1979)

Glasses containing up to 7 at.% nitrogen were prepared in the system Y‐Si‐Al‐O‐N. The glass transition temperature, hardness, and relative fracture toughness increase and the thermal expansion coefficient decreases with increasing nitrogen content. Weight losses after 350 h in 95°C distilled water are not simply related to nitrogen content, but for some compositions they are half that reported for fused silica. The electrical conductivity at 548°C and 10 kHz is 7.8×10 −10 (Ω·cm) −1 for one composition. Fourier transform ir spectroscopic analysis indicates the presence of Si‐N bonds in the glasses. The data suggest that nitrogen substitutes for oxygen in the glass network to produce a more highly cross‐linked structure.
Local effect of glycine substitution in a model helical peptide (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLocal effect of glycine substitution in a model helical peptidePingchiang C. Lyu, Ping Chuan Wang, Mark I. Liff, and Neville R. KallenbachCite this: J. Am. Chem. Soc. 1991, 113, 9, 3568–3572Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/ja00009a052https://doi.org/10.1021/ja00009a052research-articleACS PublicationsRequest reuse permissionsArticle Views114Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts