gebhart/patrepeval huggingface dataset:
Transient global amnesia after clioquinol: five personal observations from outside Japan. (1979)

Five personal observations of an acute amnestic episode in younger individuals after intake of clioquinol are described together with three observations from the medical literature. In five of these cases the episode began after an unusually large dose, in three after a therapeutic one with a latency of about 24 hours. The clinical aspect closely resembled classical transient global amnesia but the episode after clioquinol lasted longer (24 hours to three days) and a more or less extensive retrograde amnesia persisted permanently. In one patient after three tablets of Mexase a clioquinol concentration of 12 microgram/ml in plasma was found 24 hours after the specified dose, which is an unexpectedly high concentration compared to those reported as late as 24 hours after a single equal dose of Mexase or any other clioquinol-containing preparation. Another patient had a brief relapse two years after the first episode, after a single therapeutic dose of another clioquinol preparation.
Control of Early Solidification by the Use of High Frequency Electromagnetic Field in the Continuous Casting of Steel (1998)

In order to improve surface quality of continuously cast steel, alternating magnetic field was applied through the copper mold to the early solidification zone of round billet. The mold has a number of slits and was specifically designed to achieve the efficient penetration of the field as well as high stiffness. A mold size is 0.18 m in internal diameter and is surrounded with a multi-turn induction coil. Casting velocity is 1.2m/min. The capacity of high frequency generator is 300kW and the frequency is 25kHz.0.11% carbon steel was cast to investigate the effects of the intensity of magnetic field and the imposing area on the surface quality of billets. Even under the strong magnetic field, the meniscus level was controled precisely by RFLC method (Resonant Frequency Level Control Method) detecting the small shift of resonant frequency of high frequency generator.Surface marks on the cast billets had three types by the imposition of electromagnetic field. Regular surface marks caused by the mold oscillation have disappeared by selecting the optimum meniscus level under suitable electric power. By the use of developed two fluids model based on VOF code, dynamics of meniscus shape at the early solidification zone during oscillation were studied theoretically. The model shows that the disappearance of oscillation marks is responsible for the stability of interfacial shape between flux and molten steel by the imposition of electromagnetic field.
Oxidative degradation of bilirubin produces vasoactive compounds (2000)

Subarachnoid haemorrhage is often followed by haemolysis and concomitant oxidative stress, and is frequently complicated by pathological vasoconstriction or cerebral vasospasm. It is known that upregulation of haem oxygenase (HO-1) is induced by oxidative stress and results in release of biliverdin and bilirubin (BR), which are scavengers of reactive oxygen species (ROS). Here we report biomimetic studies aimed at modelling pathological conditions leading to oxidative degradation of BR. Oxidative degradation products of BR, formed by reaction with hydrogen peroxide (an ROS model system), demonstrated biological activity by stimulating oxygen consumption and force development in vascular smooth muscle from porcine carotid artery. Analogous biological activity was observed with vasoactive cerebrospinal fluid from subarachnoid haemorrhage patients. Three degradation products of BR were isolated: two were assigned as isomeric monopyrrole (C9H11N2O2) derivatives, 4-methyl-5-oxo-3-vinyl-(1, 5-dihydropyrrol-2-ylidene)acetamide and 3-methyl-5-oxo-4-vinyl-(1, 5-dihydropyrrol-2-ylidene)acetamide and the third was 4-methyl-3-vinylmaleimide (MVM), a previously isolated photodegradation product of biliverdin. Possible mechanisms of oxidative degradation of BR are discussed. Tentative assignment of these structures in the cerebrospinal fluid (CSF) of cerebral vasospasm patients has been made. It is proposed that one or more of the degradation products of biliverdin or bilirubin are involved in complications such as vasospasm and or pathological vasoconstriction associated with haemorrhage.
Efficient Decomposition of Unitary Matrices in Quantum Circuit Compilers (2022)

Unitary decomposition is a widely used method to map quantum algorithms to an arbitrary set of quantum gates. Efficient implementation of this decomposition allows for the translation of bigger unitary gates into elementary quantum operations, which is key to executing these algorithms on existing quantum computers. The decomposition can be used as an aggressive optimization method for the whole circuit, as well as to test part of an algorithm on a quantum accelerator. For the selection and implementation of the decomposition algorithm, perfect qubits are assumed. We base our decomposition technique on Quantum Shannon Decomposition, which generates O(344n) controlled-not gates for an n-qubit input gate. In addition, we implement optimizations to take advantage of the potential underlying structure in the input or intermediate matrices, as well as to minimize the execution time of the decomposition. Comparing our implementation to Qubiter and the UniversalQCompiler (UQC), we show that our implementation generates circuits that are much shorter than those of Qubiter and not much longer than the UQC. At the same time, it is also up to 10 times as fast as Qubiter and about 500 times as fast as the UQC.
Route prediction using trip observations and map matching (2013)

This paper uses location data traces (from GPS, Mobile Signals etc.) of past trips of vehicles to develop algorithm for predicting the end-to-end route of a vehicle. Focus is on overall route prediction rather than predicting road segments in short term. Researches in past for route prediction makes use of raw location data traces data decomposed into trips for such route predictions. This paper introduces an additional step to convert trips composed of location data traces points to trips of road network edges. This requires the algorithm to make use of road networks. We show that efficiency in storage and time complexity can be achieved without sacrificing the accuracy by doing so. Moreover, its well-known that location traces data has inherent inaccuracies due to hardware limitations of devices. Most of the researches don't handle it. This paper presents the results of route prediction algorithms under inaccuracies in data.
<title>Fundamentals of the interferometric fiber optic gyroscope</title> (1996)

This paper reviews the basics of the interferometric fiber-optic gyro : Sagnac effect, reciprocity, all-fiber components, integrated optics, signal processing principles, and recent trends like multi-axis gyro with source sharing or multiplexing, and erbium-doped fiber source.
Design and analysis of a multilink access subsystem based on the Batcher-banyan network architecture (1992)

A multilink access subsystem based on the Batcher-banyan network architecture is proposed. With this subsystem, multiple physical output links connecting a pair of switching nodes can be shared in an effective way. The subsystem is also configurational so that there is no restriction on any particular partition of physical output links. This is accomplished by executing the proposed multilink access algorithm on a modified Batcher sorter. It is shown that the required hardware can be integrated into the Batcher sorter, and the multilink access algorithm can be integrated with the contention resolution three-phase algorithm. The overhead incurred due to the running of the multilink access algorithm is calculated and the asymptotic performance analyses of the resulting single queue multilink access switch are presented. Results show that the proposed architecture has higher capacity than the unilink access counterpart, has low delay, and has low packet loss probability with small buffer size.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cytoplasmic Decay of Intergenic Transcripts in <i>Saccharomyces cerevisiae</i> (2006)

Eukaryotes produce a number of noncoding transcripts from intergenic regions. In Saccharomyces cerevisiae, such cryptic unstable transcripts (CUTs) are thought to be degraded in the nucleus by a process involving polyadenylation and 3'-to-5' degradation by the nuclear exosome. In this work, we examine the degradation pathway of the RNA SRG1, which is produced from an intergenic region and contributes to the regulation of the SER3 gene by promoter occlusion during SRG1 transcription. Although there is some effect on SRG1 transcript levels when the nuclear exosome is compromised, the bulk of the SRG1 RNA is degraded in the cytoplasm by decapping and 5'-to-3' exonucleolytic digestion. Examination of other CUTs suggests that individual CUTs can be degraded by a variety of different mechanisms, including nuclear decay, cytoplasmic decapping and 5'-to-3' decay, and nonsense-mediated decay. Moreover, some CUTs appear to be associated with polyribosomes. These results indicate that some CUTs can be exported from the nucleus and enter translation before being degraded, identifying a potential mechanism for the evolution of new protein-encoding genes.
Characterization of proteins by sequential isoelectric focusing on immobilized pH gradients and electrospray mass spectrometry (1995)

The coupling of isoelectric focusing on immobilized pH gradients (IPG) with electrospray-mass spectrometry (ES-MS) was applied to the characterization of proteins according to two different and important properties, such as net surface charge and molecular mass. From a technical point of view, these methods are complementary, since ES-MS requires ion-free samples as usually supplied by isoelectric focusing on IPGs. This report describes the experiments carried out on model proteins to demonstrate the feasibility of the sequential application of these two techniques for the characterization of proteins. A minimum of 5 micrograms protein was needed for good signal by mass spectrometry. The following proteins were studied: myoglobin, truncated interleukin-6-mutein, recombinant cytochrome c551 and insulin-like growth factor I. Extraction from the IPG matrix was carried out in 70% acetonitrile/30% water/0.05% trifluoroacetic acid either by passive diffusion or by centrifugation through a 0.22 micron Amicon membrane, with protein recoveries of 80-85%.
Recognition of Auto‐ and Exoantigens by V4‐34 Gene Encoded Antibodies (2000)

The antigenic specificities of 24 V4-34-encoded monoclonal antibodies were compared with the amino acid sequence. The specificities were divided into three categories, red blood cells, B lymphocytes and auto/exoantigens. Six anti-I monoclonal antibodies, with multiple substitutions in their VH region, did not bind B lymphocytes or auto/exoantigens. Reactivity to these two antigens segregated with the 16 anti-i monoclonal antibodies, which were derived from the near germline V4-34 gene. All anti-i monoclonal antibodies bound B lymphocytes, albeit with varying intensities. B-cell binding correlated with basic amino acids in the VH-CDR3. Reactivity to auto/exoantigens was demonstrated only by a subset anti-i monoclonal antibodies and did not correlate with B-lymphocyte or i-antigen binding. These anti-ssDNA reactive monoclonal antibodies had basic amino acids in the VH-CDR3, strongly supporting the suggested role of arginine in DNA binding. However, an arginine-rich CDR3 was not enough to ensure DNA reactivity, since six other anti-i monoclonal antibodies that fulfilled this criteria did not bind ssDNA. Thus it is possible that the anti-DNA reactivity of V4-34-encoded monoclonal antibodies is mediated by the classic antigen-binding groove generated by the CDRs of the heavy/light chains. In contrast, anti-B-cell/i-antigen reactivity is mediated, unconventionally, by the V4-34 protein with a dominant influence of the VH-CDR3.
Increased Concentrations of Antibody-Bound Circulatory Cell-Free DNA in Rheumatoid Arthritis (2007)

These results provide new evidence for a role of cell-free DNA-antibody complexes in the etiology of RA, suggest new avenues for basic research, and may prove to be relevant to diagnosis and assessment of therapy.
Polymer nanocomposite dielectrics - the role of the interface (2005)

The incorporation of silica nanoparticles into polyethylene increased the breakdown strength and voltage endurance significantly compared to the incorporation of micron scale fillers. In addition, dielectric spectroscopy showed a decrease in dielectric permittivity for the nanocomposite over the base polymer, and changes in the space charge distribution and dynamics have been documented. The most significant difference between micron scale and nanoscale fillers is the tremendous increase in interfacial area in nanocomposites. Because the interfacial region (interaction zone) is likely to be pivotal in controlling properties, the bonding between the silica and polyethylene was characterized using Fourier transformed infrared (FTTR) spectroscopy, electron paramagnetic resonance (EPR), and x-ray photoelectron spectroscopy (XPS). The picture which is emerging suggests that the enhanced interfacial zone, in addition to particle-polymer bonding, plays a very important role in determining the dielectric behavior of nanocomposites.
Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene (1999)

The four members of the MEF2 family of MADS-box transcription factors, MEF2-A, MEF2-B, MEF2-C and MEF2-D, are expressed in overlapping patterns in developing muscle and neural cell lineages during embryogenesis. However, during late fetal development and postnatally, MEF2 transcripts are also expressed in a wide range of cell types. Because MEF2 expression is controlled by translational and post-translational mechanisms, it has been unclear whether the presence of MEF2 transcripts in the embryo reflects transcriptionally active MEF2 proteins. To define the temporospatial expression pattern of transcriptionally active MEF2 proteins during mouse embryogenesis, we generated transgenic mice harboring a lacZ reporter gene controlled by three tandem copies of the MEF2 site and flanking sequences from the desmin enhancer, which is active in cardiac, skeletal and smooth muscle cells. Expression of this MEF2-dependent transgene paralleled expression of MEF2 mRNAs in developing myogenic lineages and regions of the adult brain. However, it was not expressed in other cell types that express MEF2 transcripts. Tandem copies of the MEF2 site from the c-jun promoter directed expression in a similar pattern to the desmin MEF2 site, suggesting that transgene expression reflects the presence of transcriptionally active MEF2 proteins, rather than other factors specific for DNA sequences flanking the MEF2 site. These results demonstrate the presence of transcriptionally active MEF2 proteins in the early muscle and neural cell lineages during embryogenesis and argue against the existence of lineage-restricted MEF2 cofactors that discriminate between MEF2 sites with different immediate flanking sequences. The discordance between MEF2 mRNA expression and MEF2 transcriptional activity in nonmuscle cell types of embryos and adults also supports the notion that post-transcriptional mechanisms regulate the expression of MEF2 proteins.
Kinematic Pose Rectification for Performance Analysis and Retrieval in Sports (2018)

The automated extraction of kinematic parameters from athletes in video footage allows for direct training feedback and continuous quantitative assessment of an athlete's performance. Recent developments in the field of deep learning enable the measurement of kinematic coefficients directly from human pose estimates. However, the detection quality decreases while errors and noise increase with the complexity of the scene. In aquatic training scenarios, for instance, continuous pose estimation suffers from several orthogonal errors like switched joint predictions between the left and right sides of the body. In this paper, we analyze different error modes and present a rectification pipeline for improving the pose predictions using merely joint coordinates. We show experimentally that joint rectification equally improves the detection of key-poses, which are essential for a continuous qualitative performance assessment and pose retrieval, as well as posture visualization for quantitative training feedback.
A Mobile Asteroid Surface Scout (MASCOT) for the Hayabusa 2 Mission to 1999 JU3: The Scientific Approach (2013)

A Mobile Asteroid Surface Scout (MASCOT) for the Hayabusa 2 Mission to 1999 JU3: The Scientific Approach
Binding of the <i>Escherichia coli</i> cyclic AMP receptor protein to DNA fragments containing consensus nucleotide sequences (1989)

Binding of the Escherichia coli CRP protein to DNA fragments carrying nucleotide sequences closely corresponding to the consensus is very tight with a dissociation time of over 2 h in our conditions. The concentration of cyclic AMP required for this binding is below the physiological range of intracellular cyclic AMP concentrations. Changes in nucleotide sequence at positions that are not well-conserved between different naturally-occurring CRP sites allow a more rapid dissociation of CRP-DNA complexes. There is an inverse correlation between the stability of CRP binding to sites in vitro and the repression by glucose of expression dependent on these sites in vivo: expression that is dependent on the tighter binding sites cannot be repressed by the inclusion of glucose in the growth medium.
Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder (2016)

This manuscript reviews biological abnormalities shared by autism spectrum disorder (ASD) and epilepsy. Two neuropathological findings are shared by ASD and epilepsy: abnormalities in minicolumn architecture and γ-aminobutyric acid (GABA) neurotransmission. The peripheral neuropil, which is the region that contains the inhibition circuits of the minicolumns, has been found to be decreased in the post-mortem ASD brain. ASD and epilepsy are associated with inhibitory GABA neurotransmission abnormalities including reduced GABAA and GABAB subunit expression. These abnormalities can elevate the excitation-to-inhibition balance, resulting in hyperexcitablity of the cortex and, in turn, increase the risk of seizures. Medical abnormalities associated with both epilepsy and ASD are discussed. These include specific genetic syndromes, specific metabolic disorders including disorders of energy metabolism and GABA and glutamate neurotransmission, mineral and vitamin deficiencies, heavy metal exposures and immune dysfunction. Many of these medical abnormalities can result in an elevation of the excitatory-to-inhibitory balance. Fragile X is linked to dysfunction of the mGluR5 receptor and Fragile X, Angelman and Rett syndromes are linked to a reduction in GABAA receptor expression. Defects in energy metabolism can reduce GABA interneuron function. Both pyridoxine dependent seizures and succinic semialdehyde dehydrogenase deficiency cause GABA deficiencies while urea cycle defects and phenylketonuria cause abnormalities in glutamate neurotransmission. Mineral deficiencies can cause glutamate and GABA neurotransmission abnormalities and heavy metals can cause mitochondrial dysfunction which disrupts GABA metabolism. Thus, both ASD and epilepsy are associated with similar abnormalities that may alter the excitatory-to-inhibitory balance of the cortex. These parallels may explain the high prevalence of epilepsy in ASD and the elevated prevalence of ASD features in individuals with epilepsy.
Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project (1997)

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Optical power limiting properties of two-photon absorbing fluorene and dithienothiophene-based chromophores (2003)

We have synthesized efficient two-photon absorbing fluorene and dithienothiophene (DTT) derivatives with electron donors (D) or electron acceptors (A) which are attached symmetrically or asymmetrically at the both end of conjugated links, forming D-π-D and D-π-A structures. The two-photon absorption (TPA) cross-section values (σ) of these chromophores were evaluated by the nonlinear transmission measurements using 8 ns laser pulse, and also by the two-photon-induced fluorescence method with 80 fs pulse laser. The σ values obtained were larger by the nanosecond pulse laser than that by the femtosecond laser. This result suggests that the relative contribution of the excited state absorption becomes more manifested when longer time scale pulses are used. The strong nonlinear absorption including TPA of all these materials induced an efficient optical power limiting (OPL) activity. The trend in OPL behavior agreed well with the size of the TPA intensity.
Joint audio-video object tracking (2002)

This paper presents an object localization and tracking algorithm integrating audio and video-based object localization results. A face tracking algorithm and a microphone array are used to compute two single-modality speaker position estimates. These position estimates are then combined into a global position estimate using a decentralized Kalman filter. Experiments with a model railway show that such an approach yields more robust results for audio-visual object tracking than either modality by itself.
Low-power low-voltage chopped transconductance amplifier for noise and offset reduction (1997)

This paper describes the principle and design of a CMOS low-power, low-voltage, chopped transconductance amplifier, for noise and offset reduction in mixed analogue digital applications. The operation is based on chopping and dynamic element matching, to reduce noise and offset, without excessive increase of the charge injection residual offset. Experimental results show residual offsets of less than 150µV at 100kHz chopping frequency, a signal to noise ratio of 95dB, in audio band, for 100KHz chopping and a THD of -89dB. The power consumption is 594µW.
Fast collision detection among multiple moving spheres (1998)

This paper presents an event-driven approach that efficiently detects collisions among multiple ballistic spheres moving in the 3D space. Adopting a hierarchical uniform space subdivision scheme, we are able to trace the trajectories of spheres and their time-varying spatial distribution. We identify three types of events to detect the sequence of all collisions during our simulation: collision, entering, and leaving. The first type of event is due to actual collisions, and the other two types occur when spheres move from subspace to subspace in the space. Tracing all such events in the order of their occurring times, we are able to avoid fixed time step simulation. When the size of the largest sphere is bounded by a constant multiple of that of the smallest, it takes O(n~/sub c/ log n+n~/sub e/ log n) time with O(n) space after O(n log n) time preprocessing to simulate n moving spheres, where n~/sub c/ and n~/sub e/ are the number of actual collisions and that of entering and leaving events during the simulation, respectively. Since n~/sub e/, depends on the size of subspaces, we modify the collision model from kinetic theory for molecular gas to determine the subspace sizes for the space subdivision scheme, that minimize simulation time. Experimental results show that collision detection can be done in linear time in n over a large range.
Geology of hill end trough Molong high: The merrions tuff – its Genesis (1976)

"Geology of hill end trough Molong high: The merrions tuff – its Genesis." Exploration Geophysics, 7(1), p. 26