gebhart/patrepeval huggingface dataset:
Design and Implementation of a Mobile-Care System over Wireless Sensor Network for Home Healthcare Applications (2006)

According to home healthcare requirement of chronic patients, this paper proposes a mobile-care system integrated with a variety of vital-sign monitoring, where all the front-end vital-sign measuring devices are portable and have the ability of short-range wireless communication. In order to make the system more suitable for home applications, the technology of wireless sensor network is introduced to transmit the captured vital signs to the residential gateway by means of multi-hop relay. Then the residential gateway uploads data to the care server via Internet to carry out patient's condition monitoring and the management of pathological data. Furthermore, the system is added in the alarm mechanism, which the portable care device is able to immediately perceive the critical condition of the patient and to send a warning message to medical and nursing personnels in order to achieve the goal of prompt rescue.
Quantification of metabolites in breast cancer patients with different clinical prognosis using HR MAS MR spectroscopy (2010)

Absolute quantitative measures of breast cancer tissue metabolites can increase our understanding of biological processes. Electronic REference To access In vivo Concentrations (ERETIC) was applied to high resolution magic angle spinning MR spectroscopy (HR MAS MRS) to quantify metabolites in intact breast cancer samples. The ERETIC signal was calibrated using solutions of creatine and TSP. The largest relative errors of the ERETIC method were 8.4%, compared to 4.4% for the HR MAS MRS method using TSP as a standard. The same MR experimental procedure was applied to intact tissue samples from breast cancer patients with clinically defined good (n = 13) and poor (n = 16) prognosis. All samples were examined by histopathology for relative content of different tissue types and proliferation index (MIB-1) after MR analysis. The resulting spectra were analyzed by quantification of tissue metabolites (β-glucose, lactate, glycine, myo-inositol, taurine, glycerophosphocholine, phosphocholine, choline and creatine), by peak area ratios and by principal component analysis. We found a trend toward lower concentrations of glycine in patients with good prognosis (1.1 µmol/g) compared to patients with poor prognosis (1.9 µmol/g, p = 0.067). Tissue metabolite concentrations (except for β-glucose) were also found to correlate to the fraction of tumor, connective, fat or glandular tissue by Pearson correlation analysis. Tissue concentrations of β-glucose correlated to proliferation index (MIB-1) with a negative correlation factor (-0.45, p = 0.015), consistent with increased energy demand in proliferating tumor cells. By analyzing several metabolites simultaneously, either in ratios or by metabolic profiles analyzed by PCA, we found that tissue metabolites correlate to patients' prognoses and health status five years after surgery. This study shows that the diagnostic and prognostic potential in MR metabolite analysis of breast cancer tissue is greater when combining multiple metabolites (MR Metabolomics).
Characterization of Serologically Dominant Outer Membrane Proteins of<i>Neisseria gonorrhoeae</i> (1980)

The proteins of the outer membrane of Neisseria gonorrhoeae play an important role in the serotyping system defined by K. H. Johnston et al. (J. Exp. Med. 143:741-758, 1976). This study attempted to delineate the molecular arrangement of the major proteins of the outer membrane of the gonococcus by using three approaches. First, natural protein-protein relationships were demonstrated by symmetrical, two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Second, proteins exposed on the surface of outer membrane vesicles were cross-linked by using the bifunctional reagents dimethyl-3,3'-dithiobispropionimidate and dithiobis[succinimidyl propionate]. Third, specific antigen-antibody interactions on the surface of membrane vesicles were analyzed by radioautographic techniques. The major proteins of the outer membrane of the gonococcus were defined, and a nomenclature was devised to take into account the effects of heat and reducing agents on the resolution of these proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Results of cross-linking experiments strongly suggest that two of the major proteins of the gonococcal outer membrane (proteins 1 and 3) form a hydrophobically associated trimeric unit in situ which can be stabilized by selective cross-linking reagents. Results substantiated that these proteins are responsible for imparting serotypic specificity.
Aflatoxins and growth impairment: A review (2011)

Aflatoxins, fungal toxins produced by Aspergillus flavus and Aspergillus parasiticus in a variety of food crops, are well known as potent human hepatocarcinogens. Relatively less highlighted in the literature is the association between aflatoxin and growth impairment in children. Foodborne aflatoxin exposure, especially through maize and groundnuts, is common in much of Africa and Asia--areas where childhood stunting and underweight are also common, due to a variety of possibly interacting factors such as enteric diseases, socioeconomic status, and suboptimal nutrition. The effects of aflatoxin on growth impairment in animals and human children are reviewed, including studies that assess aflatoxin exposure in utero and through breastfeeding. Childhood weaning diets in various regions of the world are briefly discussed. This review suggests that aflatoxin exposure and its association with growth impairment in children could contribute a significant public health burden in less developed countries.
Multigenic Control of Pod Shattering Resistance in Chinese Rapeseed Germplasm Revealed by Genome-Wide Association and Linkage Analyses (2016)

The majority of rapeseed cultivars shatter seeds upon maturity especially under hot-dry and windy conditions, reducing yield and gross margin return to growers. Here, we identified quantitative trait loci (QTL) for resistance to pod shatter in an unstructured diverse panel of 143 rapeseed accessions, and two structured populations derived from bi-parental doubled haploid (DH) and inter-mated (IF2) crosses derived from R1 (resistant to pod shattering) and R2 (prone to pod shattering) accessions. Genome-wide association analysis identified six significant QTL for resistance to pod shatter located on chromosomes A01, A06, A07, A09, C02, and C05. Two of the QTL, qSRI.A09 delimited with the SNP marker Bn-A09-p30171993 (A09) and qSRI.A06 delimited with the SNP marker Bn-A06-p115948 (A06) could be repeatedly detected across environments in a diversity panel, DH and IF2 populations, suggesting that at least two loci on chromosomes A06 and A09 were the main contributors to pod shatter resistance in Chinese germplasm. Significant SNP markers identified in this study especially those that appeared repeatedly across environments provide a cost-effective and an efficient method for introgression and pyramiding of favorable alleles for pod shatter resistance via marker-assisted selection in rapeseed improvement programs.
The longitudinal observation of the effect of antibiotics on human tear lysozyme activity. (1989)

It is well known that lysozyme, which catalyzes the hydrolysis of bacterial cell walls, is one of the important substances protecting the eye surface from bacterial infections. It was reported that the aminoglycoside antibiotics strongly inhibited the tear lysozyme activity. The lysozyme activity of tears which were added to different concentrations of two aminoglycoside antibiotics and three other antibiotics was determined longitudinally. No influence of any antibiotics on tear lysozyme activity was found. Therefore it is unnecessary to worry about that the use of aminoglycoside antibiotics may weaken the defence function of the eye.
Stress–strain behavior in extension of elastomer networks with crosslinks of different lenghts (1973)

Abstract Stress–strain behavior in extension and the swelling of polymer networks with different lenghts of crosslinks is reported. These networks were prepared by copolymerization of butyl acrylate with different amounts of various difunctional comonomers which yield crosslinks of 4, 7, 10, and 16 bonds in length. The efficiency of the comonomers in crosslinking is low, improving with increasing length of the chain between their unsaturated endgroups. Analysis of a large number of stress–strain data obtained at elongations between 2 and 8% elongation showed that in this deformation range the stress–strain relation based on the statistical theory of elasticity represents the data better than does Hooke's law or the Mooney‐Rivlin relation. It was found that the relation between the modulus at small deformations and the swelling ratio of the various samples inindependent of the length of the crosslinks. Also the shapes of the Mooney‐Rivlin curves are the same for all networks. Furthermore, the creep behavior of various networks with different crosslink lengths is the same for networks compared at the same elastically effective chain concentration. It is concluded that the lenght of the crosslinks, at least up to 16 bonds, does not affect the elastic response of polymer networks.
Stereo matching based on segmented B‐spline surface fitting and accelerated region belief propagation (2015)

The authors propose a new stereo matching algorithm based on an iterative optimisation framework including bi‐cubic B‐spline surface fitting and accelerated region belief propagation (BP). They first compute the initial cost and disparity map by the adaptive support‐weight approach and then launch the iterative process in which the disparity space image is refined via the bi‐cubic B‐spline fitting and optimised via the accelerated region BP. Two innovations are contained in the algorithm: (i) disparity space image refinement based on segmented bi‐cubic B‐spline surface fitting; and (ii) an accelerated region message passing approach for BP. The algorithm is verified on the Middlebury benchmark and experimental results show the algorithm is effective and achieves the state‐of‐the‐art accuracy.
Galectin-3 Is a Negative Regulator of Lipopolysaccharide-Mediated Inflammation (2008)

Galectin-3 is a beta-galactoside-binding lectin that plays an important role in inflammatory diseases. It also interacts with the surface carbohydrates of many pathogens, including LPS. However, its role in infection is not fully understood. Data presented herein demonstrate for the first time that galectin-3 is a negative regulator of LPS-induced inflammation. Galectin-3 is constitutively produced by macrophages and directly binds to LPS. Galectin-3-deficient macrophages had markedly elevated LPS-induced signaling and inflammatory cytokine production compared with wild-type cells, which was specifically inhibited by the addition of recombinant galectin-3 protein. In contrast, blocking galectin-3 binding sites by using a neutralizing Ab or its ligand, beta-lactose, enhanced LPS-induced inflammatory cytokine expression by wild-type macrophages. In vivo, mice lacking galectin-3 were more susceptible to LPS shock associated with excessive induction of inflammatory cytokines and NO production. However, these changes conferred greater resistance to Salmonella infection. Thus, galectin-3 is a previously unrecognized, naturally occurring, negative regulator of LPS function, which protects the host from endotoxin shock but, conversely, favors Salmonella survival.
Bacteriophage λ Having <i>Eco</i> RI Endonuclease Sites Only in the Nonessential Region of the Genome (1974)

A derivative of lambda b221 that has lost by mutation all EcoRI restriction sites has been isolated by alternative growth on restrictive and nonrestrictive strains. It has an efficiency of plating equal to 1 on the restrictive strain. Genetic cross of this bacteriophage with lambda plac5 imm21 gave rise to recombinants of intermediate restricting ratios. The analysis of the EcoRI endonuclease-cleaved DNA by polyacrylamide gel electrophoresis, compared with the genetic results, has permitted identification of EcoRI endonuclease cleavage sites in the recombinants. The genotypes are: lambda plac5 CI857 sRIlambda3(0)sRIlambda2(0)sRIlambda1(0) and lambda plac5 CI857 sRIlambda2(0)sRIlambda1(0). The remaining cleavage sites, respectively, sRIlac sRIlambda4 and sRIlac sRIlambda4 sRIlambda3, are all located in a region nonessential for bacteriophage multiplication. The involvement of these mutant bacteriophages as vector for foreign genes are discussed.
The palatability of amino acids and related compounds to rainbow trout, <i>Salmo gairdneri</i> Richardson (1989)

Using a behavioural assay, the palatability of urea, taurine, betaine and the 20 common amino acids (L‐isomers) to rainbow trout was determined. The trout responded positively only to aqueous solutions of leucine, isoleucine, proline, phenylalanine, tryptophan, methionine, glutamate, arginine, taurine and urea. Proline, the most effective compound, was active at 10 ‐4 m but not 10 ‐5 m. Palatibility was not directly related to test solution pH; concentration and molecular structure apparently played a greater role. There is good, though not perfect, agreement between the behavioural results obtained here and published electrophysiological data on the palatal sensitivity of rainbow trout to these substances.
Anti-inflammatory and Antioxidant Properties of HDLs Are Impaired in Type 2 Diabetes (2011)

In patients with T2D, the content of oxidized fatty acids is increased and the anti-inflammatory and antioxidant activities of HDLs are impaired.
Prognostic Significance of <sup>99m</sup>Tc Hynic-rh-Annexin V Scintigraphy During Platinum-Based Chemotherapy in Advanced Lung Cancer (2007)

TAS is a promising test to predict tumor response in patients with advanced lung cancer early in the course of platinum-based chemotherapy.
Cell transformation results in the loss of the density-dependent translational regulation of the expression of fibroblast growth factor 2 isoforms. (1999)

Alternative initiation of translation at three CUG and one AUG start codons leads to the synthesis of four isoforms of fibroblast growth factor 2 (FGF-2) that have distinct intracellular localizations and affect the cell phenotype differently. We show here that the expression of FGF-2 CUG-initiated isoforms decreases in a cell-density-dependent manner in normal human skin fibroblasts (HSFs) concomitantly with the FGF-2 mRNA level. In contrast, CUG-initiated FGF-2 expression is constitutive in SK-HEP-1 cells and in HSFs transformed with SV40 large T antigen. Cell transfection using a plasmid containing the FGF-2 mRNA leader fused to chloramphenicol acetyl transferase demonstrated that up-regulation of the CUG codons depends on cis-elements located in this leader. Furthermore, UV cross-linking experiments revealed a correlation between CUG codons utilization and the binding of several proteins to the mRNA leader. On the basis of the presence of an internal ribosome entry site (IRES) in the FGF-2 mRNA, we used bicistronic vectors to transfect normal and transformed cells. The density-dependent regulation in normal HSFs was cap-dependent, whereas the constitutive CUG-initiated FGF-2 expression in transformed cells occurred essentially by an IRES-dependent mechanism. Unexpectedly, the use of the AUG start codon occurred exclusively by internal entry, which suggests the presence of a second independent IRES in the FGF-2 mRNA that would be constitutive. A study of the eIF-4E levels and of the 4E-BP1 phosphorylation state at increasing cell densities showed a decrease of the eIF-4E level, concomitant with 4E-BP1 dephosphorylation in normal cells but not in transformed cells. These data point out a complex mechanism for the regulation of FGF-2 isoforms expression involving both the cap-dependent and the cap-independent initiation of translation and favor a positive role of CUG-initiated FGF-2 in cellular proliferation and transformation.
Distribution of novel polymorphisms of the interleukin-8 and CXC receptor 1 and 2 genes in systemic sclerosis and cryptogenic fibrosing alveolitis (2000)

This report describes an association between SSc and 2 polymorphisms occurring close to each other in the CXCR-2 gene. This finding and its functional significance need to be confirmed and analyzed in future studies.
New circuit theory of multiconductor transmission lines resulting from a new practice of noise reduction (2014)

In modern life, we are surrounded by and filled with electromagnetic noise caused by the dominant use of energy in the form of electricity. This situation is brought about by the fact that the noise is not understood theoretically. A new practice of noise reduction was introduced for the construction of Heavy Ion Medical Accelerator in Chiba (HIMAC). The key concept is a symmetric three-line circuit that arranges power supplies, noise filters and magnets around a third central ground line. A continuous theoretical effort forced us to find a new circuit theory involving a multiconductor transmission-line system starting from Maxwell's equations without any approximation. We discuss the essence of all of these experimental and theoretical developments with the hope to remove unnecessary electromagnetic noise not only from power supplies, but also from all electric devices. The newly derived circuit theory of multiconductor transmission lines is universal, and establishes the validity of the practice of noise reduction.
Surface modification of titanium and titanium alloys by ion implantation (2010)

Titanium and titanium alloys are widely used in biomedical devices and components, especially as hard tissue replacements as well as in cardiac and cardiovascular applications, because of their desirable properties, such as relatively low modulus, good fatigue strength, formability, machinability, corrosion resistance, and biocompatibility. However, titanium and its alloys cannot meet all of the clinical requirements. Therefore, to improve the biological, chemical, and mechanical properties, surface modification is often performed. In view of this, the current review casts new light on surface modification of titanium and titanium alloys by ion beam implantation.
Competitive routing in networks with polynomial costs (2002)

We study a class of noncooperative general topology networks shared by N users. Each user has a given flow which it has to ship from a source to a destination. We consider a class of polynomial link cost functions adopted originally in the context of road traffic modeling, and show that these costs have appealing properties that lead to predictable and efficient network flows. In particular, we show that the Nash equilibrium is unique, and is moreover efficient. These properties make the polynomial cost structure attractive for traffic regulation and link pricing in telecommunication networks. We finally discuss the computation of the equilibrium in the special case of the affine cost structure for a topology of parallel links.
Nurses urged to stay firm on pay as MPs get 4.7% increase (1994)

The announcement of a 4.7 per cent pay rise for MPs will be used by staff side in the battle for an improved pay award, the Royal College of Nursing said last week.
Expression Sites of Two Byssal Protein Genes of <i>Mytilus galloprovincialis</i> (1996)

Mussels form byssal threads that can attach tenaciously to wet and irregular surfaces. The byssus consists of a fibrous collagenous core, and at least two types of polyphenolic proteins surround it. One of these proteins, designated Mgfp-1, coats the collagenous core; the other, designated Mgfp-2, is the major component of the terminal adhesive plaque of byssal threads. Both proteins contain 3,4-dihydroxyphenylalanine (DOPA) in their primary sequences. In this study, the sites of expression of the genes encoding the polyphenolic proteins were investigated in Mytilus galloprovincialis. By northern blot analysis, we found that the expression of both genes is foot-specific. Northern blot analysis of RNA isolated from the distal end and the remaining proximal portion of the foot indicated that the Mgfp-2 gene is expressed primarily in the distal part, whereas Mgfp-1 expression occurs in both parts. In situ hybridization indicated that the Mgfp-1 gene transcript is localized in the accessory gland along the ventral groove of the foot, and the Mgfp-2 gene transcript is localized in the phenol gland near the foot apex. Thus, it was shown that tissues expressing Mgfp-1 and Mgfp-2 are located around the ventral groove in an arrangement appropriate for byssus formation.
A new preparation of rat extensor digitorum longus muscle for intravital investigation of the microcirculation. (1991)

The extensor digitorum longus (EDL) muscle is a fast contracting muscle with 60% of Type IIB fibres at the surface. We developed a surgical procedure for exposing this surface from which the microcirculation can be visualized via intravital microscopy. From video recorded microscopic images we determined that microvascular perfusion at the surface is fairly stable for at least 5 hours. Among 7 anaesthetized rats (male Wistar), the density of perfused capillaries decreased at a rate of 4% per hr. The average velocity of red cells in perfused capillaries remained constant at 0.14 mm/s. In order to demonstrate the usefulness of the preparation we report 2 sample experiments involving muscle contraction and aging. The major advantages of EDL preparation are (1) absence of mechanical manipulation of the muscle during exposure, (2) no requirement for surface superfusion following exposure, and (3) independence of the visibility of the microcirculation from rat size and age.
Einfluß von Endoxan (Cyclophosphamid) und 6-Mercaptopurin auf den Nucleinsäure-Stoffwechsel der Rattenmilz während der Synthese von Antikörpern gegen Brucella abortus (1968)

1. Endoxan hemmt, insbesondere während der Erstimmunisierung, die Ausbildung von Antikörpern gegen Brucella abortus; 6-Mercaptopurin hat einen weitaus geringeren Effekt. 2. Beide Substanzen vermindern die DNS-Synthese in der Rattenmilz erheblich, die der RNS hingegen nur wenig. 3. Die Induktion der Tyrosin-α-Ketoglutarat-Transaminase in der Rattenleber wird durch Endoxan nicht gestört. 4. Diese Ergebnisse lassen den Schluß zu, daß bei der Erstimmunisierung zur Ausbildung der Antikörper eine DNS-Synthese unerläßlich ist.
Long‐term retention of gadolinium in tissues from nephrogenic systemic fibrosis patient after multiple gadolinium‐enhanced MRI scans: case report and implications (2007)

Nephrogenic systemic fibrosis (NSF) is a painful and debilitating fibrosing disorder of the skin and systemic tissues. It is associated with exposure to Gd, used in MRIs and MRAs, in patients with renal insufficiency. We here present an illustrative example of a young patient who underwent multiple Gd-enhanced scans, both before and after developing severe NSF. We examined biopsy tissues for quantification of detectable insoluble Gd deposits using automated scanning electron microscopy/energy dispersive X-ray spectroscopy. High concentrations of Gd associated with calcium and phosphorus in skin persisted even 3 years after the last exposure to Gd. Such long-term retention of Gd raises further concerns about the utility and safety of Gd-based contrast agents. Residual Gd chelates, after initial and rapid renal clearance, can dissociate into insoluble, toxic Gd(3+) that precipitates with tissue anions. Bone serves as a site for Gd storage. Subsequent clearance and mobilization from such stores may explain the variable latency of onset of NSF. We hypothesize that long-term persistence and slow release of Gd(3+) from bone stores can be a cause for concern of Gd-associated toxicity with long latency.