gebhart/patrepeval huggingface dataset:
Effect of temporal pulse shape on optical damage (2007)

The conditions under which optical materials are susceptible to laser-induced damage is a topic which has been the subject of considerable study. Laser parameters such as wavelength and temporal pulse duration have been studied extensively. Until this work the effect of temporal pulse shape has not been considered. The authors present here data from a simple single-parameter model and a supporting experiment which predicts that a flat-in-time pulse will produce damage at approximately 80% of the fluence of a Gaussian pulse of the same duration.
252Cf plasma desorption mass spectrometry in the synthesis of porphyrin model systems (1992)

252Cf plasma desorption mass spectrometry has been used in the characterization of more than 100 synthetic porphyrins ranging in mass from 614 u for tetraphenylporphyrin to over 2000 u for some porphyrin model systems. In virtually every case, 252Cf plasma desorption mass spectrometry yielded an intense ionized molecule ion [M.+ and/or (M+H)+], irrespective of the groups appended to the porphyrin. The appended groups include carboxylic acids, amides, imides, chloroacetamides, Fmoc-protected amino acids, aromatic amines, nitriles, alkynes, alkenes, esters, active esters, benzyl ethers, acetals, dithioacetals, ketones, imines, phenols, quinone, hydroquinone, ferrocene, cyanine dyes, trimethylsilyl protecting groups, nitro groups, and combinations of these functionalities. Metalloporphyrins and porphyrin-porphyrin dimers are also analyzed with ease. Resolved isotopic peaks were observed for porphyrins with molecular weights below 1000, and unresolved isotopic peaks yielding average masses were observed for porphyrin compounds with higher molecular weights. The limited resolution in the higher molecular weight range does not lessen the utility of the method because the observation of the molecule ions [M.+ and/or (M+H)+] provides unambiguous evidence concerning the success of the synthesis. The 252Cf plasma desorption mass spectra of porphyrins are not complicated by chemical transformations. This method is ideally suited for rapid analysis of synthetic porphyrins and provides a powerful tool for chemists engaged in the synthesis of complex organic molecules.
Analysis of High-Throughput Ancient DNA Sequencing Data (2011)

Advances in sequencing technologies have dramatically changed the field of ancient DNA (aDNA). It is now possible to generate an enormous quantity of aDNA sequence data both rapidly and inexpensively. As aDNA sequences are generally short in length, damaged, and at low copy number relative to coextracted environmental DNA, high-throughput approaches offer a tremendous advantage over traditional sequencing approaches in that they enable a complete characterization of an aDNA extract. However, the particular qualities of aDNA also present specific limitations that require careful consideration in data analysis. For example, results of high-throughout analyses of aDNA libraries may include chimeric sequences, sequencing error and artifacts, damage, and alignment ambiguities due to the short read lengths. Here, I describe typical primary data analysis workflows for high-throughput aDNA sequencing experiments, including (1) separation of individual samples in multiplex experiments; (2) removal of protocol-specific library artifacts; (3) trimming adapter sequences and merging paired-end sequencing data; (4) base quality score filtering or quality score propagation during data analysis; (5) identification of endogenous molecules from an environmental background; (6) quantification of contamination from other DNA sources; and (7) removal of clonal amplification products or the compilation of a consensus from clonal amplification products, and their exploitation for estimation of library complexity.
New Developments of Differentiation Therapy of Acute Myeloid Leukemia (2017)

Background: A typical feature of acute myeloid leukemia (AML) consists in the blockade of the cell differentiation process. Many experimental studies have shown that some chemical compounds induce the selective differentiation of hematopoietic cell lines, thus supporting the rationale of using these agents to treat AML by forcing these cells to undergo a process of terminal differentiation. From these studies emerged the potential of all-trans retinoic acid (ATRA) to induce the differentiation of acute promyelocytic cells (APLs) and to treat these patients. The introduction of ATRA in the therapy of these patients improved the treatment of APLs, providing evidence that ATRA, combined with standard chemotherapy or arsenic trioxide (ATO) gives a curative effect in most of these patients. Attempts to emulate the effects of ATRA using other differentiation agents have failed. Keywords: Cell differentiation, clinical trials, differentiation inducers, leukemia, molecular genetics, targeted therapy, therapy.
ATS-6 Experiment Summary (1975)

The ATS-6 is the most advanced experimental satellite that has evolved from the Application Technology Satellite Program conducted and implemented by NASA Goddard Space Flight Center (NASA/GSFC). This project utilizes a state-of-the-art spacecraft and ground terminal network to perform advance studies and to conduct technological demonstrations in a large number of scientific areas. The design and implementation of this unique spacecraft permitted multiple experimentation simultaneously. The control of the spacecraft is performed at ATS Operational Control Center (ATSOCC) located at NASA/GSFC. Experimentation which was performed covered a wide spectrum of communications, technological, meterorological, and scientific subjects. Three principal ground terminals are utilized to assist the experimenters to acquire data. Data reduction and analysis are performed by the many facilities at NASA/GSFC in support of the experimenters.
Nucleotide sequence of the xylose isomerase gene from<i>Streptomyces violaceoniger</i> (1988)

Journal Article Nucleotide sequence of the xylose isomerase gene from Streptomyces violaceoniger Get access Daniel Drocourt, Daniel Drocourt Search for other works by this author on: Oxford Academic PubMed Google Scholar Samir Bejar, Samir Bejar Search for other works by this author on: Oxford Academic PubMed Google Scholar Thierry Calmels, Thierry Calmels Search for other works by this author on: Oxford Academic PubMed Google Scholar Jean Paul Reynes, Jean Paul Reynes Search for other works by this author on: Oxford Academic PubMed Google Scholar Gérard Tiraby Gérard Tiraby 1Laboratoire de Microbiologie et Gé'nétique appliqués du CNRS, CRBGC, Université Paul Sabatier118 route de Narbonne, 31062 Toulouse Cédex, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 19, 11 October 1988, Page 9337, https://doi.org/10.1093/nar/16.19.9337 Published: 11 October 1988
Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins (2015)

Methods to site-specifically and densely label proteins in cellular ultrastructures with small, bright, and photostable fluorophores would substantially advance super-resolution imaging. Recent advances in genetic code expansion and bioorthogonal chemistry have enabled the site-specific labeling of proteins. However, the efficient incorporation of unnatural amino acids into proteins and the specific, fluorescent labeling of the intracellular ultrastructures they form for subdiffraction imaging has not been accomplished. Two challenges have limited progress in this area: (i) the low efficiency of unnatural amino acid incorporation that limits labeling density and therefore spatial resolution and (ii) the uncharacterized specificity of intracellular labeling that will define signal-to-noise, and ultimately resolution, in imaging. Here we demonstrate the efficient production of cystoskeletal proteins (β-actin and vimentin) containing bicyclo[6.1.0]nonyne-lysine at genetically defined sites. We demonstrate their selective fluorescent labeling with respect to the proteome of living cells using tetrazine-fluorophore conjugates, creating densely labeled cytoskeletal ultrastructures. STORM imaging of these densely labeled ultrastructures reveals subdiffraction features, including nuclear actin filaments. This work enables the site-specific, live-cell, fluorescent labeling of intracellular proteins at high density for super-resolution imaging of ultrastructural features within cells.
Rab14 and Its Exchange Factor FAM116 Link Endocytic Recycling and Adherens Junction Stability in Migrating Cells (2012)

Rab GTPases define the vesicle trafficking pathways underpinning cell polarization and migration. Here, we find that Rab4, Rab11, and Rab14 and the candidate Rab GDP-GTP exchange factors (GEFs) FAM116A and AVL9 are required for cell migration. Rab14 and its GEF FAM116A localize to and act on an intermediate compartment of the transferrin-recycling pathway prior to Rab11 and after Rab5 and Rab4. This Rab14 intermediate recycling compartment has specific functions in migrating cells discrete from early and recycling endosomes. Rab14-depleted cells show increased N-cadherin levels at junctional complexes and cannot resolve cell-cell junctions. This is due to decreased shedding of cell-surface N-cadherin by the ADAM family protease ADAM10/Kuzbanian. In FAM116A- and Rab14-depleted cells, ADAM10 accumulates in a transferrin-positive endocytic compartment, and the cell-surface level of ADAM10 is correspondingly reduced. FAM116 and Rab14 therefore define an endocytic recycling pathway needed for ADAM protease trafficking and regulation of cell-cell junctions.
Performance of a magnetic susceptometer for thin films and surfaces (1986)

The design and performance of a magnetic susceptometer for thin films and surfaces is described. The device uses a 14-MHz resonant circuit driven by a tunnel diode oscillator with a superconducting meander line as the inductive element. Magnetic properties of thin films deposited near the line in ultrahigh vacuum at low temperature affect the inductance of the meander line and thus the frequency. The device can detect a susceptibility change equal to that of a change in Fe thickness of 0.03 atomic layers. The minimum detectable change in the diamagnetism of superconducting Pb corresponds to a thickness difference of 10−3 Å. The effect of 10−6 atomic layers of Fe can be detected by its depairing effect on a superconducting Pb film. The oscillator circuit including the film being studied is analyzed and the oscillation frequency calculated so that the effect of the various circuit elements can be determined. Suggestions for extending this technique are given.
Brief Report: Human Mesenchymal Stem-Like Cells Facilitate Floating Tumorigenic Cell Growth via Glutamine-Ammonium Cycle (2015)

How mesenchymal stem cells (MSCs) promote tumor growth remains incompletely understood. Here, we show that mesenchymal stem-like cells (MSLCs) are commonly present in malignant pleural effusion or ascites of cancer patients, where they directly interact with tumor cells. Chemokines and chemokine receptors, especially the CCL2/CCR2 pathway, are involved in this interaction. As a result, MSLCs exert tumor-promoting effects by enhancing the proliferation and colony formation of tumor-repopulating cells. The underlying molecular basis involves MSLC release of glutamine to tumorigenic cells. Inhibition of glutamine uptake impedes MSC-mediated tumor-promoting effects. More intriguingly, MSLCs take up tumor cell-released ammonium that, in turn, favors MSLC growth. Thus, glutamine and ammonium form a vicious cycle between MSLCs and tumorigenic cells. These findings suggest a potential clinical application by targeting MSLCs in patients with malignant pleural effusions or ascites.
58.2: In‐Cell Type Adaptive Touch for Electrophoretic Display (2009)

Abstract In‐cell type adaptive touch technology for Electro‐Phoretic Display has been developed and implemented in 2.1 inch QVGA electronic paper. Here, we have used two types of a‐Si photosensor arrays along with overall capacitor and applied touch algorithm adapted depending upon the amount of light intensity, resulting in enhancing touch sensitivity regardless of environmental condition.
‘Effervescent’ atomization in two dimensions (2013)

Abstract A planar Savart water sheet uniformly seeded with small air bubbles in a large surface concentration is studied as a model experiment of the so-called ‘effervescent’ atomization process. This two-dimensional setup allows for a quantitative observation of all the steps of the sheet’s disintegration into a collection of disjointed droplets. The bubbles are heterogeneous nucleation sites which puncture the sheet with holes. The dynamics of the opening of holes competes with the simultaneous nucleation rate of new holes in a statistically stationary fashion. The liquid constituting the sheet is then transiently concentrated in a web of ligaments of various lengths and diameters, at the junction between adjacent holes. Their breakup produces the final spray. We provide a complete description of the ligament web statistics when nucleation is synchronous, and we show that the drop size dispersion from the breakup of a single ligament is responsible for the shape of the overall spray drop size distribution.
Idiolects (1979)

Idiolects are among the most neglected subjects of linguistic study, but the material for their investigation lies around us on every side. Our own linguistic peculiarities do not form a good starting-point; our habitual use of particular pronunciations or idioms prevents us from realising how unusual they are. When we are listening to a good lecture, we are too preoccupied with the speaker’s subject-matter to pay much attention to his manner of speaking, but a bad lecture provides ideal conditions for the study of the speaker’s idiolect. The use of the term does not mean that each linguistic feature is unique, though no doubt each speaker is unique in the possession of a particular set of linguistic features.
Aerobic and anaerobic biodegradability of a flocculant polymer (2001)

Flocculant polymers are used to improve the efficiency of separation processes used in wastewater treatment. The subsequent fate and effects of these additives are uncertain, however, with some previous reports indicating them to be biodegradable while others indicate complete recalcitrance. The biodegradability of a common flocculant polymer was therefore evaluated, using both aerobic and anaerobic batch assays. Knowledge of the polymer's chemical composition also allowed degradation stoichiometries to be calculated for complete biodegradation and also for incomplete degradation to several hypothesized end products. Results showed conclusively that the polymer was subject to partial degradation by both aerobic and anaerobic cultures. Measured oxygen consumption under aerobic conditions, and gas production under anaerobic conditions, both indicate that the partial destruction of pendant cationic moieties occurs, but that the polymer's CH2 backbone remains essentially intact. These results allow seemingly contradictory previous reports to be explained. The findings are relevant to the environmental fate of these polymers as well as certain treatment process effects.
Influence of Modified Hexamethylene-diamine on the Properties of Polyurea (2010)

Novel sterically hindered chain extender, diacetyl hexamethylene-diamine (MHAD) was synthesized by acetylating hexamethylene-diamine (HAD) with glacial acetic acid in presence of phosphoric acid, in order to reduce high reactivity of synthesizing polyurea and improve its properties. Chemical structures of modified HAD was confirmed through FTIR, the determination of the nitrogen content, High resolution ESI-FTICR mass spectrometry and <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> H-NMR analysis. The results of measuring its melting stages showed that purity of the product was better. Polyureas were synthesized by two-step solution process of 4,4'-diphenyl diisocyanate(MDI) and amine terminated polyether (Jeffamine D-2000) with different chain extenders. The influence of modified HAD on gel time of the polyurea was investigated. The gel time was prolonged, that is, the reaction activity was decreased when MHAD was used as chain extenders instead of HAD. Thermal stability of polyureas was not affected, and its mechanical properties were heightened remarkably.
Freeze-Drying for Microencapsulation of Turmeric Oleoresin Using Modified Starch and Gelatin (2014)

The aims of this study were to assess the turmeric oleoresin microencapsulation by freeze-drying with modified starch/gelatin and to evaluate its stability during storage at different temperatures and light. Encapsulated turmeric oleoresin w stored at −20, 25 and 60C, in the absence of light, and at 25C in the presence of light, and analyzed over a period of 6 weeks for curcumin and total phenolic contents and color. The different concentrations of wall material showed no significant effect on the curcumin retention. The best conditions for microencapsulation of turmeric oleoresin were: wall material composed of 30 g/100 g of modified starch + 1 g/100 g gelatin and mechanical homogenization. Encapsulated material was more stable during storage at −20C and less stable at 25C in the presence of light. Practical Applications Turmeric oleoresin, obtained by organic solvent extraction of turmeric (Curcuma longa L.), is a brownish-orange oily liquid used as a flavoring agent and a food color. However, despite the natural antioxidants content, turmeric oleoresin is sensitive to light, heat and oxygen. Furthermore, the oleoresins are immiscible in the aqueous medium, which makes difficult its use in food matrices. Encapsulation can solve some of these problems increasing stability and solubility of turmeric oleoresin. Use of freeze-drying on the encapsulation may be interesting as the low temperature of the process can minimize adverse chemical changes and transform the physical characteristics of turmeric oleoresin without providing significant losses related to bioactive compounds.
IDENTIFICACIÓN DE BARRERAS EDUCATIVAS EN EL PROCESO DE TRANSICIÓN DE LA EDUCACIÓN MEDIA A LA EDUCACIÓN SUPERIOR EN PERSONAS SORDAS: UNA PERSPECTIVA DESDE LOS INTERPRETES (2010)

Este artículo describe el proceso de la investigación que explora las barreras educativas en la transición de la educación media a la educación superior en personas Sordas. Se aborda desde una perspectiva cualitativa, con un carácter exploratorio, siguiendo una lógica descriptiva, su unidad de análisis se conforma desde las opiniones y apreciaciones de los intérpretes de Lengua de Señas Colombiana, la información se diligenció con entrevistas semi-estructuradas centradas en el problema, el análisis de los datos se realizó siguiendo el método de Leininger (2006) el cual consiste en cuatro fases, luego de este proceso se realizó el análisis, y apareamiento conceptual en el cual se identificaron las barreras generadas en la transición educativa de la persona Sorda desde las características externas al centro, características internas al centro, características internas al aula y mesosistema.
Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars (2018)

Macronutrient composition of excess energy influences pathways of IHTG: CARB increases DNL, while SAT increases and UNSAT decreases lipolysis. SAT induced the greatest increase in IHTG, insulin resistance, and harmful ceramides. Decreased intakes of SAT could be beneficial in reducing IHTG and the associated risk of diabetes.
A 216fps 4096&#x00D7;2160p 3DTV set-top box SoC for free-viewpoint 3DTV applications (2011)

3DTV promises to become the mainstream of next-generation TV systems. High resolution 3DTV provides users with a vivid watching experience. Moreover, free-viewpoint view synthesis (FVVS) extends the common two-view stereo 3D vision into virtual reality by generating unlimited views from any desired view point. In the next-generation 3DTV systems, the set-top box (STB) SoC requires both a high-definition (HD) multiview video-coding (MVC) decoder to recon struct the real camera-captured scenes and a free-viewpoint view synthesizer to generate the virtual scenes.
Smart grid technologies (2009)

The need for power semiconductor devices with high-voltage, high- frequency, and high-temperature operation capability is growing, especially for advanced power conversion and military applications, and hence the size and weight of the power electronic system are reduced. Development of 15-kV SiC IGBTs and their impact on utility applications is discussed.
Clinical application of high speed B mode echocardiography (1977)

This study discusses the clinical application of high speed B mode echocardiography to a wide variety of heart diseases. We used a rapid mechanical sector scan at 30 frames per second and 120 scanning lines per frame, resulting in real time observation of cardiac structures. The sector angle was relatively wide (maximum 90 degrees). The tomograms were synchronized with the electrocardiogram and recorded on ordinary 35 mm or Polaroid film in conjunction with 8 mm cinematography. Heart cross sections could be recorded even in the presence of arrhythmia. We used a flat or focused, 10 mm diameter transducer made of lead zirconate-titanate with a resonant frequency of 2 or 3 MHz at a repetition rate of 3.6 kHz. High speed B mode echocardiography is a means of observing cross sections of the heart that can contribute to the improvement of accuracy in cardiac diagnosis.
Synthesis of some heterocyclic derivatives of biguanide with antibacterial activity (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of some heterocyclic derivatives of biguanide with antibacterial activityJohn W. James, James A. Baker, and Leslie F. WigginsCite this: J. Med. Chem. 1968, 11, 5, 942–945Publication Date (Print):September 1, 1968Publication History Published online1 May 2002Published inissue 1 September 1968https://pubs.acs.org/doi/10.1021/jm00311a006https://doi.org/10.1021/jm00311a006research-articleACS PublicationsRequest reuse permissionsArticle Views279Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts