gebhart/patrepeval huggingface dataset:
Intractable chest pain in cardiomyopathy: treatment by a novel technique of cardiac cryodenervation with quantitative immunohistochemical assessment of success. (1993)

A novel method of cardiac denervation by cryoablation has been developed experimentally. The technique uses liquid nitrogen delivered under pressure to ablate the principal sources of cardiac innervation--namely, the adventitia surrounding the aorta, pulmonary arteries, and veins. The technique has been verified experimentally both in vivo by physiological means and in vitro by quantitative immunohistochemistry and the measurement of myocardial noradrenaline concentrations. A 35 year old woman presented with intractable precordial pain, normal epicardial coronary arteries, and hypertrophic cardiomyopathy. Her symptoms were refractory to maximal medical treatment and she was thought to be unsuitable for either conventional myocardial revascularisation, autotransplantation, or allografting with the concomitant risk of transplant coronary artery disease. She therefore underwent cardiac denervation by the method developed in the laboratory. There was quantitative immunohistochemical evidence of extrinsic cardiac denervation associated with a considerable improvement in her symptoms. This improvement persisted during a follow up period of over 16 months.
Preparation and Characterisation of ZnO Thin Films by Spray Pyrolysis Method (2018)

Zinc oxide (ZnO) thin film is a transparent conducting oxide thin film and has attracted significant attention because of its potential applications in optoelectronic, solar cells and heat mirrors. The ZnO thin films were deposited by spray pyrolysis method. The films were grown on glass substrates at 415, 445, 475 and 505 oC substrate temperatures. The transmittance in the visible region and energy band gap values range from 79% to 85% and 3.32 to 3.34eV respectively. Raman spectroscopic analysis indicates that there are two peaks at 436 and 556 cm-1. It was concluded that ZnO thin films with optimal growth conditions using spray pyrolysis is an excellent material for transparent conducting oxide films.
Harvard Middle Eastern and Islamic review. Volume I, Number I, 021994. pp. x, 168. Cambridge, Mass., Center for Middle Eastern Studies, Harvard University. US $9.00 (annual subscription US $16.00). (1995)

Harvard Middle Eastern and Islamic review. Volume I, Number I, 021994. pp. x, 168. Cambridge, Mass., Center for Middle Eastern Studies, Harvard University. US $9.00 (annual subscription US $16.00). - Volume 5 Issue 3
Biosynthesis of Parathyroid Hormone (1978)

General Aspects of the Synthesis of Secretory ProteinsA matter of great interest has been the physiologic role of biosynthetic precursors in the pathway of the formation of parathyroid hormone and also the overall effects of biosynthetic precursors of secretory proteins generally. Many different proteins of biologic importance represented by such diverse classes as hormones, enzymes, antibodies, collagen and viral and membrane proteins are synthesized in the form of larger precursors that are subsequently modified by cleavage to smaller forms.One apparent function of a precursor sequence is evident with insulin. The C-peptide of proinsulin, the . . .
President's letter (1996)

</br>![][1]</img> What a year! That is my initial thought in reflecting back on this past year as president of the ISHRS. It has been a challenging experience for me, my family and my staff. I know that most of you do not realize (because I hadn't myself) how very much time and energy it take to
Genetics of Endometrial Cancers (2010)

Endometrial cancers exhibit a different mechanism of tumorigenesis and progression depending on histopathological and clinical types. The most frequently altered gene in estrogen-dependent endometrioid endometrial carcinoma tumors is PTEN. Microsatellite instability is another important genetic event in this type of tumor. In contrast, p53 mutations or Her2/neu overexpression are more frequent in non-endometrioid tumors. On the other hand, it is possible that the clear cell type may arise from a unique pathway which appears similar to the ovarian clear cell carcinoma. K-ras mutations are detected in approximately 15%-30% of endometrioid carcinomas, are unrelated to the existence of endometrial hyperplasia. A beta-catenin mutation was detected in about 20% of endometrioid carcinomas, but is rare in serous carcinoma. Telomere shortening is another important type of genomic instability observed in endometrial cancer. Only non-endometrioid endometrial carcinoma tumors were significantly associated with critical telomere shortening in the adjacent morphologically normal epithelium. Lynch syndrome, which is an autosomal dominantly inherited disorder of cancer susceptibility and is characterized by a MSH2/MSH6 protein complex deficiency, is associated with the development of non-endometrioid carcinomas.
Production of Collagenase and Inhibitor (Timp) by Normal, Rheumatoid and Osteoarthritic Synovium <i>In Vitro</i>: Effects of Hydrocortisone and Indomethacin (1981)

1. The amounts of latent and active collagenase and of collagenase inhibitor (TIMP) produced by two normal, three rheumatoid and two osteoarthritic synovial specimens in culture were compared. Normal synovia produced TIMP, but little latent enzyme. Rheumatoid synovia produced higher levels of total collagenase activity than normal, of which up to 50% in one sample was present in the medium in an active form, whereas no specific inhibitory activity due to TIMP was detectable. The amounts of collagenase and TIMP produced by osteoarthritic synovia were more variable and appeared to reflect the degree of inflammation in the tissue at the time of initiating the cultures. 2. Concentrations of TIMP were usually higher in the culture media of normal, rheumatoid and osteoarthritic synovia when hydrocortisone was present. Correspondingly, amounts of total collagenase were reduced. Production of prostaglandin E (PGE) were inhibited in a dose-dependent manner by hydrocortisone. 3. Indomethacin had no consistent effect on the production of TIMP by rheumatoid and osteoarthritic synovia, although it tended to depress production of collagenase. The production of TIMP by normal synovia was depressed by indomethacin. No PGE was detectable in the media when indomethacin was present. 4. These results are consistent with those from previous animal studies, and we conclude that the balance between production of collagenase and TIMP may be critical in determining the extent of the destructive processes in arthritis. The ability of hydrocortisone to suppress production of collagenase and to increase free TIMP concentration, as well as to inhibit synthesis of prostaglandin, may explain in part how the drug exerts its therapeutic effects in patients with rheumatoid arthritis.
Simple grating synthesis algorithm (2000)

Many authors (including this one) have suggested that the problem of synthesizing a grating from its reflection spectrum is significantly more difficult than the direct problem of obtaining the spectrum from the grating. Fortunately, this view is mistaken. One can synthesize a grating from any reflection spectrum by direct solution of the standard coupled-mode equations while simultaneously evaluating a simple integral to obtain the grating strength. This approach has the advantage of being based on a well-understood set of equations, making it amenable to physical interpretation, mathematical approximation, and generalization.
Precise Method Using Resistivity Imaging Tool for Estimation of High Resolution Reservoir Parameters Calibrated to Reservoir Description Tool and Nuclear Magnetic Resonance Data for Better Reservoir Characterization (2010)

Abstract This paper explores a successful method for predicting high-resolution saturation, permeability, and porosity from resistivity imaging acquired with wireline logging. By integrating the best attributes of resistivity imaging and both wireline NMR and pressure testing information, this method is shown to produce better reservoir evaluation and production enhancement when applied to a homogenous sandstone reservoir that is relatively free from micro-bound porosity and layering. Three available wireline formation evaluation technologies used in concert with conventional macro-wireline logs can substantially improve reservoir evaluation in terms of porosity, permeability and saturation. These technologies include the following: Nuclear magnetic resonance (NMR), includes tools such as the MRIL®-Prime tool, which provides accurate estimates of formation porosity, permeability, saturation, and hydrocarbon properties, albeit with relatively coarse vertical resolution compared to resistivity images, which can be enhanced by post-processing techniques.Resistivity imaging, such as the X-tended Range Micro Imager (XRMI™) tool with vertical resolution down to 0.10 in. These tools provide high-resolution porosity, permeability, and saturation prediction in clastic reservoirs based on estimates of micro-bound and producible porosity by means of integration with NMR and conventional logs.Pressure and sampling tools, such as the Reservoir Description Tool (RDT™) formation tester, which provides reservoir pressure, anisotropy, lateral and vertical connectivity, producibility, and fluid mobility measurements, which can be converted to permeability using fluid viscosity from fluid sampling. The new method uses a special post-processing technique for enhancing the vertical resolution of the NMR data. By providing reliable and accurate predictions of saturation, permeability, and permeability, the method integrates NMR-bounded porosity, conventional resistivity, and the NMR saturation resulting from the magnetic resonance imaging analysis (MRIAN™) post-processing model.
Structure of the Ebola VP35 interferon inhibitory domain (2009)

Ebola viruses (EBOVs) cause rare but highly fatal outbreaks of viral hemorrhagic fever in humans, and approved treatments for these infections are currently lacking. The Ebola VP35 protein is multifunctional, acting as a component of the viral RNA polymerase complex, a viral assembly factor, and an inhibitor of host interferon (IFN) production. Mutation of select basic residues within the C-terminal half of VP35 abrogates its dsRNA-binding activity, impairs VP35-mediated IFN antagonism, and attenuates EBOV growth in vitro and in vivo. Because VP35 contributes to viral escape from host innate immunity and is required for EBOV virulence, understanding the structural basis for VP35 dsRNA binding, which correlates with suppression of IFN activity, is of high importance. Here, we report the structure of the C-terminal VP35 IFN inhibitory domain (IID) solved to a resolution of 1.4 A and show that VP35 IID forms a unique fold. In the structure, we identify 2 basic residue clusters, one of which is important for dsRNA binding. The dsRNA binding cluster is centered on Arg-312, a highly conserved residue required for IFN inhibition. Mutation of residues within this cluster significantly changes the surface electrostatic potential and diminishes dsRNA binding activity. The high-resolution structure and the identification of the conserved dsRNA binding residue cluster provide opportunities for antiviral therapeutic design. Our results suggest a structure-based model for dsRNA-mediated innate immune antagonism by Ebola VP35 and other similarly constructed viral antagonists.
Laboratory Study on Precipitation of Barium Sulphate in Malaysia Sandstone Cores (2009)

Scale formation is one of the most serious oil field problems that inflict water injection systems primarily when two incompatible waters are involved. Two waters are incompatible if they interact chemically and precipitate minerals when mixed. Due to the lack of reaction kinetics data, the rate of barium sulphate deposition in porous rock was measured through flooding sandstone core samples of uniform properties with supersaturated brine. The brine was formulated at the core inlet by mixing of injected sea water and formation water that contained high concentration of barium ion at various temperatures (50 -80C) and differential pressures (100 -200 psig). The rate of BaSO 4 scale formation was estimated by monitoring the core effluent's barium ion concentration. The solubility of barium sulphate scale formed and how its solubility was affected by changes in salinity and temperatures (40 -90C) were also studied. Scanning Electron Microscopy analysis was also used to examine the nature of scale deposition throughout the core. The results indicated increased rate of BaSO 4 precipitation at higher temperatures and greater brine super-saturation. The results were utilized to build a general reaction rate equation to predict BaSO 4 deposition in sandstone cores for a given temperature, brine super-saturation and differential pressures.
Generation of Inner Ear Cell Types From Embryonic Stem Cells (2006)

The senses of hearing and balance are mediated by hair cells located in the cochlea and in the vestibular organs of the vertebrate inner ear. Loss of hair cells and other cell types of the inner ear results in hearing and balance disorders that substantially diminish the quality of life. The irreversibility of hearing loss in mammals is caused by the inability of the cochlea to replace lost hair cells. No drugs are available that stimulate inner ear cell regeneration. We describe here protocols to generate inner ear progenitor cells from murine ES cells and to differentiate these progenitors into hair cells and potentially into other inner ear cell types. In addition, we provide a modification of the protocol describing culture conditions in which human ES cells express a similar set of inner ear markers. Inner ear progenitor cells, generated from ES cells, may be used for the development of cell replacement therapy for the diseased inner ear, for high-throughput drug screening, and for the study of inner ear development.
Time Savings with Rituximab Subcutaneous Injection versus Rituximab Intravenous Infusion: A Time and Motion Study in Eight Countries (2016)

ClinicalTrials.gov NCT01200758.
Construction of two SD Codes (2013)

SD codes are erasure codes that address the mixed failure mode of current RAID systems. Rather than dedicate entire disks to erasure coding, as done in RAID-5, RAID-6 and Reed-Solomon coding, an SD code dedicates entire disks, plus individual sectors to erasure coding. The code then tolerates combinations of disk and sector errors, rather than solely disk errors. It is been an open problem to construct general codes that have the SD property, and previous work has relied on Monte Carlo searches. In this paper, we present two general constructions that address the cases with one disk and two sectors, and two disks and two sectors. Additionally, we make an observation about shortening SD codes that allows us to prune Monte Carlo searches.
Gummosis, Brown Spot and Seedling Mortality in Su-babul I. Disease Incidence and Pathology of the Host (1983)

A serious disease causing gummosis and canker on stem, branches, racbii and peduncles; dark brown spots on leaflets, rachii, peduncles, young twigs, pods and seed and morlity in natural regeneration is recorded on various varieties of Leucoena leucocephala and on L. diversifolia incidence and intensity of the disease in different localities and detailed symptoms are given. The causal fungus is identified as Fusarium semitectum . The fungus has been described in culture isolated from diseased Leucaena plants. The disease was successfully reproduced on healthy plants by artificial inoculations of both stem and leaves. Cankers were found to take double the time to deVelop on stem when inoculations were made on intact surface (72 days) than on injured sUrface (36 days). Root-rot in seedlings was also successfully reproduced by sowing seeds inoculated with F. semitectum . Studies on pathological anatomy of diseased parts revealed that in stem and branches, gum cavities were formed in Phloem and Phelloderm tissues Some gummy deposits were also observed in epidormal and pallisie tissue of leaffets, in exocarp cells of affeectcd pods, in intervening spaces of sub-epidermal cells and in parenchyma cells of seed coats and in cortical cells of arfected roals. Fungal hyphae were found to spread both intra and intercellularly in the affected tissues.
Hex-Dominant Mesh Improving Quality to Tracking Hydrocarbons in Dynamic Basins (2014)

The proposed method regularizes as far as possible some verticals of a hex-dominant basin mesh; this regularization is used to optimize the numerical simulation of hydrocarbons flow in basins. The studied basins contain faults and constitute complex geometries.This mesh optimization is adapted for a new way to mesh basins called the “Constrained Grid Method” (CGM). Data constitutes some horizon surfaces; the surfaces contain tags to reconstruct the fault surfaces which represent in our case some constraints to generate a hex-dominant mesh. To make a regular hex-dominant mesh, the following steps are applied: first, the borders of horizon surfaces are extracted and optimized to get the connections between the borders as vertical as possible; this means that the border nodes have approximately the same <i>xy<i/> directions. Next, a Dirichlet equation is solved to apply a Laplacian smoothing 2D on <i>xy<i/> directions for each horizon surface. And as the connected (<i>x<i/>,<i>y<i/>) between the borders are approximately the same, as well as the implied the harmonic solutions, then the positions on (<i>x<i/>,<i>y<i/>) are minimized.
A Low-Loss 74–110-GHz Faraday Polarization Rotator (2007)

We have developed a switchable Faraday polarization rotator for 74-110 GHz with a typical room-temperature insertion loss of 0.6 dB and a maximum of ~1.3 dB. The device uses a cylindrical ferrite rod in the mode with an axial magnetic field applied by a solenoid. The ports are square metallic waveguides transitioning to ceramic tapers, which then couple to the ferrite rod. The device is designed for use at a temperature of 20 K, where typical loss is <0.5 dB. The design rotation is about plusmn45deg the zero-bias value, but up to 90deg is possible. The switching time is <10 s.
Selective Blockade of NF-κB Activity in Airway Immune Cells Inhibits the Effector Phase of Experimental Asthma (2004)

Knockout mice studies have revealed that NF-kappaB plays a critical role in Th2 cell differentiation and is therefore required for induction of allergic airway inflammation. However, the questions of whether NF-kappaB also plays a role in the effector phase of airway allergy and whether inhibiting NF-kappaB could have therapeutic value in the treatment of established asthma remain unanswered. To address these issues, we have assessed in OVA-sensitized wild-type mice the effects of selectively antagonizing NF-kappaB activity in the lungs during OVA challenge. Intratracheal administration of NF-kappaB decoy oligodeoxynucleotides to OVA-sensitized mice led to efficient nuclear transfection of airway immune cells, but not constitutive lung cells and draining lymph node cells, associated with abrogation of NF-kappaB activity in the airways upon OVA provocation. NF-kappaB inhibition was associated with strong attenuation of allergic lung inflammation, airway hyperresponsiveness, and local production of mucus, IL-5, IL-13, and eotaxin. IL-4 and OVA-specific IgE and IgG1 production was not reduced. This study demonstrates for the first time that activation of NF-kappaB in local immune cells is critically involved in the effector phase of allergic airway disease and that specific NF-kappaB inhibition in the lungs has therapeutic potential in the control of pulmonary allergy.
Modeling Software VulnerabilitiesWith Vulnerability Cause Graphs (2006)

When vulnerabilities are discovered in software, which often happens after deployment, they must be addressed as part of ongoing software maintenance. A mature software development organization should analyze vulnerabilities in order to determine how they, and similar vulnerabilities, can be prevented in the future. In this paper we present a structured method for analyzing and documenting the causes of software vulnerabilities. Applied during software maintenance, the method generates the information needed for improving the software development process, to prevent similar vulnerabilities in future releases. Our approach is based on vulnerability cause graphs, a structured representation of causes of software vulnerabilities
Plasticized poly(vinyl chloride) properties and characteristics of valinomycin electrodes. THE d.c. current-voltage curves (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPlasticized poly(vinyl chloride) properties and characteristics of valinomycin electrodes. THE d.c. current-voltage curvesMichael L. Iglehart, Richard P. Buck, and Erno. PungorCite this: Anal. Chem. 1988, 60, 4, 290–295Publication Date (Print):February 15, 1988Publication History Published online1 May 2002Published inissue 15 February 1988https://doi.org/10.1021/ac00155a003RIGHTS & PERMISSIONSArticle Views153Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (742 KB) Get e-Alerts Get e-Alerts
BATSE observations of gamma-ray burst spectra. I - Spectral diversity (1993)

We studied the time-averaged gamma-ray burst spectra accumulated by the spectroscopy detectors of the Burst and Transient Source Experiment (BATSE). The spectra are described well at low energy by a power-law continuum with an exponential cutoff N_E_(E) is proportional to E<SUP>alpha</SUP>^ exp (- E/E_0_), and by a steeper power law, N_E_(E) is proportional to E<SUP>beta</SUP>^ with α > β at high energy. However, the spectral parameters α, β, and E_0_ vary from burst to burst with no universal values. The break in the spectrum, E_0_, ranges from below 100 keV to more than 1 MeV, but peaks below 200 keV with only a small fraction of the spectra breaking above 400 keV. Consequently, it is unlikely that a majority of the burst spectra are shaped directly by pair processes, unless bursts originate from a broad redshift range. We find that the correlations among burst parameters do not fulfill the predictions of the cosmological models of burst origin, but our burst sample may not be appropriate for such a test. No correlations with burst morphology or the spatial distribution were found. We also studied the process of fitting the BATSE spectral data. For example, we demonstrate the importance of using a complete spectral description even if a partial description (e.g., a model without a high-energy tail) is statistically satisfactory.
A new guide in the surgical reconstruction of the cruciate ligaments. (1990)

The authors present a guide for the perforation of the transskeletal tibial and femoral tunnels during reconstruction of the anterior and posterior cruciate ligaments, by both arthroscopy and arthrotomy. This guide is accurate, maneuverable, light and has the advantage of being able to be oriented at different planes.