gebhart/patrepeval huggingface dataset:
High levels of Hdmx promote cell growth in a subset of uveal melanomas. (2012)

The p53 tumor suppressor pathway is inactivated in cancer either via direct mutation or via deregulation of upstream regulators or downstream effectors. P53 mutations are rare in uveal melanoma. Here we investigated the role of the p53 inhibitor Hdmx in uveal melanoma. We found Hdmx over-expression in a subset of uveal melanoma cell lines and fresh-frozen tumor samples. Hdmx depletion resulted in cell-line dependent growth inhibition, apparently correlating with differential Hdm2 levels. Surprisingly, p53 knockdown hardly rescued cell cycle arrest and apoptosis induction upon Hdmx knockdown, whereas it effectively prevented growth suppression induced by the potent p53 activator Nutlin-3. In addition, two compounds inhibiting Hdmx function or expression, SAH-p53-8 and XI-011, also elicited a growth inhibitory effect in a partly p53-independent manner. These findings suggest a novel, growth-promoting function of Hdmx that does not rely on its ability to inhibit p53. We provide evidence for a contribution of p27 protein induction to the observed p53-independent G1 arrest in response to Hdmx knockdown. In conclusion, our study establishes the importance of Hdmx as an oncogene in a subset of uveal melanomas and widens the spectrum of its function beyond p53 inhibition.
Pressure-diameter relationships of segments of human finger arteries (1986)

Pressure-diameter relationships of segments of human finger arteries, aged 57-85 years, were measured in vitro. The arteries, obtained at autopsy within 48 h after death, were stored in glucose-free Tyrode at 4 degrees C. Experiments began within 40 h after autopsy. The diameter responses to various transmural pressure changes, with and without the addition of noradrenaline to the Tyrode solution in the specimen chamber, were compared with the responses of freshly excised rat tail arteries. In general, pressure-diameter relations of human finger artery segments were similar to those of rat tail artery segments, with a steep slope in the collapse region near zero pressure. Also, spontaneous rhythmic contractions and myogenic activity induced by high transmural pressures were similar to those observed in the fresh rat tail arteries. Human finger arteries, however, could contract to complete closure both spontaneously and after addition of noradrenaline, while rat tail arteries did not. The diameter changes of the arterial segments during forced 1 Hz oscillations of 20-50 mm Hg (2.7-6.7 kPa) amplitude superimposed on a mean transmural pressure were substantially smaller than those during quasi-steady inflation-deflation ramps over the same pressure range, indicating the presence of a strong viscous wall component.
<i>Ln</i>Is a Key Regulator of Leaflet Shape and Number of Seeds per Pod in Soybean (2012)

Narrow leaflet soybean (Glycine max) varieties tend to have more seeds per pod than broad leaflet varieties. Narrow leaflet in soybean is conferred by a single recessive gene, ln. Here, we show that the transition from broad (Ln) to narrow leaflet (ln) is associated with an amino acid substitution in the EAR motif encoded by a gene (designated Gm-JAGGED1) homologous to Arabidopsis JAGGED (JAG) that regulates lateral organ development and the variant exerts a pleiotropic effect on fruit patterning. The genomic region that regulates both the traits was mapped to a 12.6-kb region containing only one gene, Gm-JAG1. Introducing the Gm-JAG1 allele into a loss-of-function Arabidopsis jagged mutant partially restored the wild-type JAG phenotypes, including leaf shape, flower opening, and fruit shape, but the Gm-jag1 (ln) and EAR-deleted Gm-JAG1 alleles in the jagged mutant did not result in an apparent phenotypic change. These observations indicate that despite some degree of functional change of Gm-JAG1 due to the divergence from Arabidopsis JAG, Gm-JAG1 complemented the functions of JAG in Arabidopsis thaliana. However, the Gm-JAG1 homoeolog, Gm-JAG2, appears to be sub- or neofunctionalized, as revealed by the differential expression of the two genes in multiple plant tissues, a complementation test, and an allelic analysis at both loci.
Antiproliferative effect of nitrosulindac (NCX 1102), a new nitric oxide-donating non-steroidal anti-inflammatory drug, on human bladder carcinoma cell lines (2004)

Non-steroidal anti-inflammatory drugs (NSAIDs) are potent antitumoral agents but their side effects limit their clinical use. A novel class of drugs, nitric oxide-donating NSAIDs (NO-NSAIDs), was found to be safer and more active than classical NSAIDs. This study explored the effect of the NO-donating sulindac derivative, NCX 1102, on three human urothelial epithelial carcinoma cell lines (T24, 647V, and 1207) and primary cultures of normal urothelial cells. Cytotoxicity, antiproliferative effect, cell cycle alterations, morphological changes, and apoptosis were investigated after treatment with NCX 1102 in comparison with the native molecule. After treatment, there was a cytotoxic effect (with IC(50) at 48 h of 23.1 micro M on 647V, 19.4 micro M on T24, and 14.5 micro M on 1207) and an antiproliferative effect on all three cell lines with NCX 1102 but not with sulindac. No effect was detected on normal urothelial cells. Flow cytometric analysis showed a differential NCX 1102-induced accumulation of cells in various phases of the cell cycle, depending on cell line and concentration. NCX 1102 induced an occurrence of multinucleated cells in all cell lines and mitotic arrest in 647V and 1207. NCX 1102-treated T24 and 647V cell lines showed a significant difference of apoptotic cell amount when compared to controls. Our results demonstrated a greater antiproliferative potency of NCX 1102 compared to its parent molecule sulindac, and suggested that this new NO-NSAID may have therapeutic impact in the management of bladder cancer.
New Ultrasonic Caliper for MWD Operations (1991)

Abstract An ultrasonic tool has been developed for MWD applications that simultaneously performs realtime bore-hole caliper measurements and realtime gas influx detection. The caliper determines the ovalness of the hole with a high degree of accuracy and excellent vertical resolution. These measurements are transmitted to the surface and also used to compensate LWD measurements. Furthermore, with early and accurate real-time caliper measurements, bore-hole instability can be detected. Real-time gas influx detection insures early and reliable gas kick detection and should provide a considerable improvement in drilling rig safety. The new tool is particularly useful for avoiding problems associated with shallow gas formation where response time for kick detection is critical.
Flexible blue-emitting encapsulated organic semiconductor DFB laser (2010)

Mechanically flexible distributed feedback (DFB) lasers are fabricated by a low-cost approach using soft-lithography from a holographic master grating. The gain material is a star-shaped oligofluorene providing laser emission from 425 to 442 nm with a soft pump threshold at 14.4 μJ/cm (2.7 kW/cm). Encapsulation of the devices enables stable operation in ambient atmosphere at a 1/e degradation energy dosage of 53 J/cm.
CNG AND HCN CHANNELS: Two Peas, One Pod (2005)

Cyclic nucleotide-activated ion channels play a fundamental role in a variety of physiological processes. By opening in response to intracellular cyclic nucleotides, they translate changes in concentrations of signaling molecules to changes in membrane potential. These channels belong to two families: the cyclic nucleotide-gated (CNG) channels and the hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels. The two families exhibit high sequence similarity and belong to the superfamily of voltage-gated potassium channels. Whereas HCN channels are activated by voltage and CNG channels are virtually voltage independent, both channels are activated by cyclic nucleotide binding. Furthermore, the channels are thought to have similar channel structures, leading to similar mechanisms of activation by cyclic nucleotides. However, although these channels are structurally and behaviorally similar, they have evolved to perform distinct physiological functions. This review describes the physiological roles and biophysical behavior of CNG and HCN channels. We focus on how similarities in structure and activation mechanisms result in common biophysical models, allowing CNG and HCN channels to be viewed as a single genre.
A flexible fingerprint identification system (1995)

In this paper we describe a fingerprint identification system which allows for the adjustment of the degree of match. The extracted features from the fingerprint image, such as location and angle are allowed to deviate by user definable margins. The system offers likely candidates from the database using these margins. The system may be requested to pick the best match or candidates may be visually examined. Such an approach allows the system to be flexible for a particular application. Furthermore, the match times can be considerably reduced for less rigorous match cases or for large database accesses.
Measurement of Roundness for an X-Ray Mono-Capillary Optic by Using Computed Tomography (2019)

X-ray computed tomography is a very useful tool for nondestructively imaging a cross section of a sample. By using a computed tomography beamline system of synchrotron radiation, we directly measured the radius of the inner reflection surface of a mono-capillary optic with an accuracy of 1.30 μm. The inner-surface deformation of a mono-capillary optic approximately 100 μm in diameter was first shown by combining radial profiles. The precise determination of the radius will contribute to an increase in fabrication precision for the mono-capillary optic.
Direct Methanol Fuel Cells: From a Twentieth Century Electrochemist’s Dream to a Twenty-first Century Emerging Technology (2005)

1. Energy Conservation and Environmental Friendliness-the Incentive for Fuel Cell Development The fuel cell is a nineteenth century invention; in the twentieth century it became the “heart” of an electrochemical power plant and power source, which is now in a stage of advanced technology development. Its first and only application since the early 1960s, has been as an auxiliary power source for space flights by the National Aeronautics and Space Administration (NASA). During the past decade, development for terrestrial (civilian and defense) applications has led to its commercialization and research on utilization in a variety of applications. Programs in the United States, Japan, Europe, and some other countries are focused on the development of fuel cell power plant/power sources for (1) base-load,
Mining opinions on the basis of their affectivity (2010)

Recent reports reveal that users daily consult Web communities opinions for getting an idea about a product/service before they buy it. Furthermore, the same users, freely and without a direct economic return, collaborate in posting new reviews to the community. In most of cases these posts contain an affective content that is needed to explain the meaning of the review, and that is ignored by recent opinion mining techniques. In this work, we propose an affective annotation model of shared reviews, which takes into account the affectivity expressed by the Web community. The annotation model is then used for improving opinion mining results. A case study demonstrating the effectiveness of the approach is also provided. The method can be exploited to better organize the collaborative work of reviews management, and to better take advantage of reviews inside the community.
Relation between Structural Changes in the Small Pulmonary Arteries and the Immediate Reversibility of Pulmonary Hypertension Following Closure of Ventricular and Atrial Septal Defects (1958)

The relative importance of organic changes and vasoconstrictive influences in the production of increased pulmonary vascular resistance in congenital heart disease is problematic. With use of a grading system previously described, a study was made of the relation between each of the grades of hypertensive pulmonary vascular disease associated with ventricular or atrial septal defects and the change of pulmonary artery blood pressure immediately following closure of the abnormal communications. The immediate reversibility of the pulmonary hypertension varies inversely with the severity of the structural changes.
ART based cell formation using combined operation sequence and time (2008)

The cell formation (CF) problem mainly deals with clustering of parts into part families and the machines into machine cells. The parts are grouped into part families based on similarities in their manufacturing and design attributes and the machines are allocated into machine cells to produce the identified part families. The zero-one part-machine incidence matrix is commonly used as input to any clustering algorithm. The output is generated in the form of block diagonal structure. Production data such as operation time, sequence of operations, batch size etc. that have significant bearing on smooth flow of materials are not considered in such methods. In this paper, an attempt has been made to develop an algorithm based on adaptive resonance theory (ART) neural network to addresses this issue by considering combination of operation sequence and operation time of the parts to enhance the quality of the solution obtained for the CF problem. A new performance measure is proposed to assess the goodness of the solution quality obtained through proposed algorithm. The performance of the proposed algorithm is tested with example problems and the results are compared with the existing methods found in the literature. The results presented clearly shows that the performance of the proposed algorithm is comparable with other methods for small size problems and better for large size problems.
A concurrent distributed system for aircraft tactical decision generation (2002)

A research program investigating the use of artificial intelligence (AI) techniques to aid in the development of a tactical decision generator (TDG) for within visual range (WVR) air combat engagements is discussed. The application of AI programming and problem-solving methods in the development and implementation of a concurrent version of the computerized logic for air-to-air warfare simulations (CLAWS) program, a second-generation TDG, is presented. Concurrent computing environments and programming approaches are discussed, and the design and performance of prototype concurrent TDG system (Cube CLAWS) are presented. It is concluded that the Cube CLAWS has provided a useful testbed to evaluate the development of a distributed blackboard system. The project has shown that the complexity of developing specialized software on a distributed, message-passing architecture such as the Hypercube is not overwhelming, and that reasonable speedups and processor efficiency can be achieved by a distributed blackboard system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Development and validation of the Canine Atopic Dermatitis Lesion Index, a scale for the rapid scoring of lesion severity in canine atopic dermatitis (2012)

The CADLI was found to be an effective measure of CAD lesion severity, strongly correlating with CADESI-03. The convenience of CADLI makes it suitable for use in both clinical research and practice.
The Science of Musical Sounds (1991)

Introduction. What is Sound? Ear and Hearing. Scales, Tunings, and Temperaments. Wind Instruments. String Instruments. Rod and Membrane Instruments. Room Acoustics. Music and Electronics. Music as Communication. References. Index.
Factor Analysis Simplified (2006)

We show how the factor analysis model for speaker verification can be successfully implemented using some fast approximations which result in minor degradations in accuracy and open up the possibility of training the model on very large databases such as the union of all of the Switchboard corpora. We tested our algorithms on the NIST 1999 evaluation set (carbon data as well as electret). Using warped cepstral features we obtained equal error rates of about 6.3% and minimum detection costs of about 0.022.
Quality of life is associated to the orthopaedic status in haemophilic patients with inhibitors (2006)

Inhibitors represent one major complication of haemophilia treatment, as they increase the risk of bleeding, physical disability and mortality. The Cost Of Care Inhibitors Study (COCIS) showed that modern strategies applied to manage patients with inhibitors adsorb high amounts of resources but provide satisfactory levels of Health-Related Quality-of-Life (HR-QoL). This paper focuses on determinants of HR-QoL in inhibitory patients. Fifty adult patients, enrolled by 11 Italian Haemophilia Centres, were clinically assessed and filled in two HR-QoL generic questionnaires: the EuroQol instrument (EQ-5D) and the Short Form-36 (SF-36). According to our results, bleeding frequency and inhibitor titres were not found associated with HR-QoL. Global HR-QoL, and in particular the physical component of wellbeing in these patients was found negatively associated with their orthopaedic condition: the EQ-5D Visual Analogue Scale (P<0.001) scores, the SF-36 domain 'physical functioning' and 'physical component summary' (P<0.01) scores were found significantly correlated with the orthopaedic joint score, even after adjusting for patients' age. These results were confirmed by those from the EQ-5D profile. To conclude, the COCIS study is the first study showing that HR-QoL in inhibitory patients is impaired by their orthopedic status, while other aspects do not seem to influence patients' global wellbeing. Our results suggest that while the management of this complication is satisfactory, the attention has now to be focused on the prevention of the orthopaedic problems in these patients, which nowadays constitute one of the most important aspects to be considered in the haemophilia care.
Designing a gesture-based interaction with an ID tag (2010)

We designed a gesture-based interface with a personal ID tag that interacts with an ambient information system. An ID tag is equipped with a vibrator, an embedded accelerometer sensor, and an RFID tag. In the suggested system, users can not only retrieve and store information, but customize interaction patterns with the ID tag that can be best suited to personal preferences. Patterns of gesture-based interaction are classified with a probabilistic algorithm developed in the study that use signal data from five different axes of the accelerometer sensor.
An improved reagent for mycobacterial nitrate reductase tests (1983)

A new crystalline reagent for nitrate reductase tests was compared with standard liquid reagents on 437 strains of mycobacteria. The results for isolates of Mycobacterium avium complex, Mycobacterium kansasii, Mycobacterium gordonae, Mycobacterium scrofulaceum, Mycobacterium fortuitum, and Mycobacterium chelonei agreed 100% with the expected results. Of the 177 Mycobacterium tuberculosis isolates, 4 were negative by the conventional method. Two of these four isolates were positive with the new reagent. Of the positive nitrate tests carried out with liquid reagents, 42% flashed instantly or faded in color; none of the tests carried out with the new crystalline reagent flashed or faded. A stronger color reaction was seen for 28% of the positive tests with the new reagent.
Microbial Formation of Comenic acid from Kojic acid (1960)

Journal Article Microbial Formation of Comenic acid from Kojic acid Get access Seiichi Nonomura, Seiichi Nonomura Agricultural Technology Department of Agriculture Sakai, Japan Search for other works by this author on: Oxford Academic Google Scholar Chuji Tatsumi Chuji Tatsumi Agricultural Technology Department of Agriculture Sakai, Japan Search for other works by this author on: Oxford Academic Google Scholar Bulletin of the Agricultural Chemical Society of Japan, Volume 24, Issue 7, 1 December 1960, Pages 741–742, https://doi.org/10.1080/03758397.1960.10857744 Published: 01 December 1960 Article history Received: 18 October 1960 Published: 01 December 1960
Metal‐Air Batteries: Metal–Air Batteries with High Energy Density: Li–Air versus Zn–Air (Adv. Energy Mater. 1/2011) (2010)

Abstract In the past decade, there have been exciting developments in the field of lithium ion batteries as energy storage devices, resulting in the application of lithium ion batteries in areas ranging from small portable electric devices to large power systems such as hybrid electric vehicles. However, the maximum energy density of current lithium ion batteries having topatactic chemistry is not sufficient to meet the demands of new markets in such areas as electric vehicles. Therefore, new electrochemical systems with higher energy densities are being sought, and metal‐air batteries with conversion chemistry are considered a promising candidate. More recently, promising electrochemical performance has driven much research interest in Li‐air and Zn‐air batteries. This review provides an overview of the fundamentals and recent progress in the area of Li‐air and Zn‐air batteries, with the aim of providing a better understanding of the new electrochemical systems.
Derepression of Uridine Diphosphate-Glucose Pyrophosphorylase ( <i>galU</i> ) in <i>capR</i> ( <i>lon</i> ), <i>capS</i> , and <i>capT</i> Mutants and Studies on the <i>galU</i> Repressor (1973)

Mutation of the capR(lon), capS, or capT genes in Escherichia coli K-12 causes overproduction of capsular polysaccharide leading to a mucoid phenotype. Several of the enzymes involved in capsular polysaccharide synthesis are derepressed in cap mutants. Previously it was shown that uridine diphosphate-glucose (UDPG) pyrophosphorylase, an enzyme involved in the synthesis of three of the nucleotide sugar precursors of the capsule, is derepressed in capR mutants. The control of galU, the gene which codes for UDPG pyrophosphorylase, is described in this study. In addition, it has been found that the enzyme is also derepressed in capS and capT mutants. The effect of galU gene dosage in cap mutants and the wild-type strain (all lysogenic for phi80) was studied by infecting them with the purified transducing phage phi80dgalU. The level of UDPG pyrophosphorylase increased in proportion to the number of galU copies added. The rate of enzyme synthesis in the mutants was about sixfold higher than in the wild type per galU gene added for multiplicities of infection from one to twenty. Thus, all the galU copies added to the wild-type lysogen were repressed. We obtain greater than 20 galU copies per cell by infecting the nonlysogenic strain which allows multiplication of phi80dgalU. With some number of galU copies greater than 20, the rate of UDPG pyrophosphorylase synthesis in the wild type approaches the mutant rate of synthesis. The results suggest that there may indeed be a galU repressor pool in the cell which can be completely titrated. This pool must be composed of more than 20 galU repressor molecules. Since the capR, capS, and capT gene products or combinations thereof are known to control other widely separated operons of the cell besides the galU gene, it is postulated that the galU repressor may be capable of binding other operators. This would account for the relatively large pool of galU repressors per cell.
Difference-covers that are not <i>k</i>-sum-covers. II (1974)

Abstract We examine the possibility of establishing the existence of a compact subset E of ℝ such that E – E contains a non-degenerate interval and the semigroup generated by E has measure zero. We show that the existence of such an E is equivalent to the existence of a sequence of difference-covers that are not k -sum-covers for each k ∈ℕ, and, further, is equivalent to the existence of an asymmetric maximal Raikov system.