gebhart/patrepeval huggingface dataset:
Role of androgen receptor and associated lysine‐demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer (2011)

Bladder cancer is approximately three times more common in men as compared to women. We and others have previously investigated the contribution of androgens and the androgen receptor (AR) to bladder cancer. JMJD2A and LSD1 are recently discovered AR coregulator proteins that mediate AR-dependent transcription via recently described histone lysine-demethylation (KDM) mechanisms. We used immunohistochemistry to examine JMJD2A, LSD1, and AR expression in 72 radical cystectomy specimens, resulting in evaluation of 129 tissue samples (59 urothelial carcinoma, 70 benign). We tested levels of these proteins for statistical association with clinicopathologic variables and patient survival. Expression of these markers was also assessed in human bladder cancer cell lines. The effects of pharmacological inhibition of LSD1 on the proliferation of these bladder cancer cells was determined. JMJD2A and AR levels were significantly lower in malignant versus benign urothelium, while increased LSD1 levels were observed in malignant urothelium relative to benign. A significant reduction in all three proteins occurred with cancer stage progression, including muscle invasion (JMJD2A/LSD1/AR), extravesical extension (JMJD2A/LSD1), and lymph node metastasis (JMJD2A/AR). Lower JMJD2A intensity correlated with additional poor prognostic features, including lymphovascular invasion, concomitant carcinoma in situ and tobacco usage, and predicted significantly worse overall survival. Pharmacological inhibition of LSD1 suppressed bladder cancer cell proliferation and androgen-induced transcription. Our results support a novel role for the AR-KDM complex in bladder cancer initiation and progression, identify JMJD2A as a promising prognostic biomarker, and demonstrate targeting of the KDM activity as an effective potential approach for bladder cancer growth inhibition.
Spectrophotometric and thermodynamic study of donor-acceptor complexes of carbazole (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectrophotometric and thermodynamic study of donor-acceptor complexes of carbazoleE. L. Ong and Manjit S. SambhiCite this: J. Phys. Chem. 1972, 76, 15, 2102–2104Publication Date (Print):July 1, 1972Publication History Published online1 May 2002Published inissue 1 July 1972https://pubs.acs.org/doi/10.1021/j100659a007https://doi.org/10.1021/j100659a007research-articleACS PublicationsRequest reuse permissionsArticle Views135Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Structural Analysis of the Protein/Lipid Complexes Associated with Pore Formation by the Bacterial Toxin Pneumolysin (2001)

Pneumolysin, a major virulence factor of the human pathogen Streptococcus pneumoniae, is a soluble protein that disrupts cholesterol-containing membranes of cells by forming ring-shaped oligomers. Magic angle spinning and wideline static (31)P NMR have been used in combination with freeze-fracture electron microscopy to investigate the effect of pneumolysin on fully hydrated model membranes containing cholesterol and phosphatidylcholine and dicetyl phosphate (10:10:1 molar ratio). NMR spectra show that the interaction of pneumolysin with cholesterol-containing liposomes results in the formation of a nonbilayer phospholipid phase and vesicle aggregation. The amount of the nonbilayer phase increases with increasing protein concentration. Freeze-fracture electron microscopy indicates the coexistence of aggregated vesicles and free ring-shaped structures in the presence of pneumolysin. On the basis of their size and analysis of the NMR spectra it is concluded that the rings are pneumolysin oligomers (containing 30-50 monomers) complexed with lipid (each with 840-1400 lipids). The lifetime of the phospholipid in either bilayer-associated complexes or free pneumolysin-lipid complexes is > 15 ms. It is further concluded that the effect of pneumolysin on lipid membranes is a complex combination of pore formation within the bilayer, extraction of lipid into free oligomeric complexes, aggregation and fusion of liposomes, and the destabilization of membranes leading to formation of small vesicles.
A technique for deriving sets of orthogonal sequences from binary parents which preserves auto-correlation properties (2002)

Binary-valued Barker sequences have close to ideal autocorrelation (AC) properties but are extremely rare. The 11-chip Barker sequence is fundamental to the performance of the IEEE 802.11 WLAN standard. This letter presents a method of deriving new sets of sequences from a binary "parent" using a generalization of the technique derived previously by the author (see IEEE Trans. Commun., vol.45, p.1379-80, Nov. 1997). The method maintains the AC properties of the original binary source and can be used to produce sequence sets orthogonal to the original. This technique is applied to produce orthogonal sets of sequences with Barker-like AC properties.
<title>Oral task-oriented dialogue for air-traffic controller training</title> (1990)

We present here an oral dialogue system designed for air-traffic controller training. The system has to handle the dialogue with a student air-traffic controller and communicate the student’s requests to the air-traffic simulator in the form of a sequence of instructions expressed in a formal command language. The system has been developed with two main objectives in mind: we tried to make it both user-friendly and robust. Different knowledge sources including the vocabulary, the phraseology, the task model and the history of dialogue, are evolving during the dialogue. These knowledge bases are represented in a unified form of hierarchical frames. The message analysis and interpretation consist of two phases: categorisation and instantiation. Then, a validity control process uses a set of semantico-pragmatic constraints. Correction procedures have also been developed to improve speech recognition performance. The speech recognition system which is being used is AMADEUS developed at the LIMSI. It is a DTW-based continuous speech recognizer. The representation of the language model used to limit the DTW search space is described as well as the way it is modified by the dialogue manager in order to permit or prohibit messages and improve recognition. In system evaluation, the classical DTW approach is compared to a probabilistic approach using dynamically updated transition probabilities.
Laminated Ceramic Interdigital Bandpass Filter (2006)

One new type of laminated ceramic interdigital bandpass filter manufactured by low temperature co-fired ceramic (LTCC) technology is presented in this article. The designed filter is constructed of conductive patterns, which are printed on various ceramic sheets. The patterns include three stepped-impedance resonators arranged in interdigital manner, and series resonance branches for transmission zeros. The simulated result for this component shows broad bandpass width plus enhanced bandstop rejection.
Circular of the Bureau of Standards no. 539 volume 9: (1960)

Introduction_ 1 Standard X-ray powder patterns: Aluminum oxide-alpha (corundum), a-Al203-3 Ammonium azide, NH4N3_ 4 Ammonium bicarbonate (teschemacherite), (NH4)HC03_ 5 Ammonium bromoplatinate, (NH4)2PtBr6-6 Ammonium perrhenate, NH4Re04_ 7 Ammonium sulfate (mascagnite), (NH4)2S04-8 Beryllium aluminum oxide (chrysoberyl), BeAl204 10 Beryllium aluminum silicate (beryl), Be3Al2(Si03)6 13 Bismuth oxyiodide, BiOI_ 16 Cadmium bromide, CdBr2_ 17 Cadmium chloride, CdCl2_ 18 Calcium aluminate 12:7, 12Ca0-7Al203_ 20 Calcium iron silicate (andradite), Ca3Fe2Si30i2_ 22 Cesium bromotellurate, Cs2TeBr6_ 24 Cesium nitrate, CsN03_ 25 Chromium orthophosphate
Functional properties of legume proteins compared to egg proteins and their potential as egg replacers in vegan food (2013)

Egg protein is used in a variety of food products due to its excellent functional properties (solubility, emulsification, foaming and gelling) and protein quality. Concerns about high cholesterol, allergies, animal welfare, high food costs, as well as the food productions negative impact on the environment has led to an increased interest in alternative protein sources that can act as egg replacers in food.\n\nThis literature study has the aim to compare the functional properties and protein quality of soy and pea with egg, this in order to evaluate their potential as egg replacers in traditional egg foods without dairy or animal ingredients. The findings showed that soy and pea protein possess similar solubility pattern as egg protein. Soy and pea protein have emulsifying properties that are similar to egg protein and changing the pH can regulate the thickness of the emulsion. Both soy and pea protein are able to form foams but pea protein is shown to be a better foaming agent than soy protein. Egg protein form stronger foams in room temperature than the two legume proteins. The gelling properties were shown to be best for egg and soy protein, but soy proteins do not form proper gels at higher temperatures and are not suitable for heat- induced food gels. Pea proteins form weak gels and are not applicable for food gels.\n\nThe drawbacks with using legume proteins as egg replacers are their content of anti-nutritional substances as well as their limitation in some sulfur containing amino acids, which affect the protein quality in a negative way. The protein quality for egg, soy and pea protein was evaluated by comparing the results from different scoring methods (e.g. PDCAAS) aimed for this. Through this evaluation, soy protein was found to be a complete protein. Pea protein was shown to be an incomplete protein, but can be complete if mutual supplementation is applied.\n\nThe study also showed that foods based on soy and pea protein do not have the same texture, color or odor as food products based on egg protein, and that the consumer acceptance for this kind of products is low. Further studies have to be carried out on optimization of formulas for legume-based products in order for them to gain consumer acceptance and succeed on the market.
CD8 T Cells Mediate Direct Biliary Ductule Damage in Nonobese Diabetic Autoimmune Biliary Disease (2010)

We previously described the NOD.c3c4 mouse, which is protected from type 1 diabetes (T1D) because of protective alleles at multiple insulin-dependent diabetes (Idd) genes, but develops autoimmune biliary disease (ABD) resembling primary biliary cirrhosis (PBC). In this paper, we characterize the NOD.ABD strain, which is genetically related to the NOD.c3c4 strain but develops both ABD and T1D. Histologically, NOD.ABD biliary disease is indistinguishable from that in NOD.c3c4 mice. The frequency of effector memory (CD44(+)CD62L(-)) and central memory (CD44(+)CD62L(+)) CD8 T cells is significantly increased in the intrahepatic lymphocyte fraction of NOD.ABD mice, and NOD.ABD CD8 T cells produce more IFN-γ and TNF-α, compared with controls. NOD.ABD splenocytes can transfer ABD and T1D to NOD.c3c4 scid mice, but only T1D to NOD scid mice, suggesting that the genetic origin of the target organ and/or its innate immune cells is critical to disease pathogenesis. The disease transfer model, importantly, shows that biliary duct damage (characteristic of PBC) and inflammation precede biliary epithelial cell proliferation. Unlike T1D where both CD4 and CD8 T cells are required for disease transfer, purified NOD.ABD CD8 T cells can transfer liver inflammation into NOD.c3c4 scid recipients, and disease transfer is ameliorated by cotransferring T regulatory cells. Unlike NOD.c3c4 mice, NOD.ABD mice do not develop anti-nuclear or anti-Smith autoantibodies; however, NOD.ABD mice do develop the antipyruvate dehydrogenase Abs typical of human PBC. The NOD.ABD strain is a model of immune dysregulation affecting two organ systems, most likely by mechanisms that do not completely coincide.
Topological analysis of the connectome of digital reconstructions of neural microcircuits (2016)

A recent publication provides the network graph for a neocortical microcircuit comprising 8 million connections between 31,000 neurons (H. Markram, et al., Reconstruction and simulation of neocortical microcircuitry, Cell, 163 (2015) no. 2, 456-492). Since traditional graph-theoretical methods may not be sufficient to understand the immense complexity of such a biological network, we explored whether methods from algebraic topology could provide a new perspective on its structural and functional organization. Structural topological analysis revealed that directed graphs representing connectivity among neurons in the microcircuit deviated significantly from different varieties of randomized graph. In particular, the directed graphs contained in the order of $10^7$ simplices {\DH} groups of neurons with all-to-all directed connectivity. Some of these simplices contained up to 8 neurons, making them the most extreme neuronal clustering motif ever reported. Functional topological analysis of simulated neuronal activity in the microcircuit revealed novel spatio-temporal metrics that provide an effective classification of functional responses to qualitatively different stimuli. This study represents the first algebraic topological analysis of structural connectomics and connectomics-based spatio-temporal activity in a biologically realistic neural microcircuit. The methods used in the study show promise for more general applications in network science.
Nanoengineered Particles for Enhanced Intra‐Articular Retention and Delivery of Proteins (2014)

Localized intra-articular delivery of anti-inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of raid clearance within few hours of injection. A new class of polymer is developed that forms self-assembled nanoparticles ranging from 300 to 900 nm and demonstrates particle size dependent prolonged retention in intra-articular joint spaces compared to bolus protein over a period of 14 d.
Hole formation in orthorhombic and tetragonal<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi mathvariant="normal">Y</mml:mi><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Ba</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Cu</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>7</mml:mn><mml:mo>−</mml:mo><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> (1987)

While in the ${\mathrm{La}}_{2\ensuremath{-}y}{\mathrm{Sr}}_{y}\mathrm{Cu}{\mathrm{O}}_{4}$ compound holes form because of doping with strontium, it is shown that in $\mathrm{Y}{\mathrm{Ba}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{7\ensuremath{-}x}$ compound holes form because upon cooling down from high temperature, or increasing the partial pressure of oxygen at constant temperature, oxygen vacancies become occupied with oxygen ions. This process manifests itself as a positive dependence of conductivity on the partial pressure of oxygen. Analysis of the resistivity data of Freitas and Plaskett reveals that upon oxygen absorption at 500\ifmmode^\circ\else\textdegree\fi{}C by the superconducting orthorhombic phase two mobile holes form per absorbed oxygen atom, while upon oxygen absorption at 700\ifmmode^\circ\else\textdegree\fi{}C by the non-superconducting tetragonal phase only one mobile hole forms per oxygen atom. Implications for the valence state of copper and oxygen in the two phases are discussed.
PALAEONTOLOGIA SINICA. Series <scp>D</scp>, volume 1. GEOLOGICAL SURVEY OF CHINA, PEKIN. Fascicle <scp>I</scp>: The Cave-deposit at Sha Kuo T'un in Fengtien. By J. G. Andersson. 1923. pp. 43, 12 plates, 20 text-figures. Fascicle 2: Painted stone age pottery from the province of Honan, China. By T. J. Arne. 1925. pp. 40, 13 plates (six in colour), 63 text-figures. Fascicle 3: The human skeletal remains from the Sha Kuo T'un cave-deposit in comparison with those from Yang Shao Tsun and with recent north China skeletal material. By Davidson Black. 1925. pp. 120, 14 plates, 86 tables. - MEMOIRS OF THE GEOLOGICAL SURVEY OF CHINA. Series A, no. 5. Preliminary report on archaeological researches in Kansu. By J. G. Andersson. Pekin. 1925. pp. 56, 12 plates. (1928)

PALAEONTOLOGIA SINICA. Series D, volume 1. GEOLOGICAL SURVEY OF CHINA, PEKIN. Fascicle I: The Cave-deposit at Sha Kuo T'un in Fengtien. By J. G. Andersson. 1923. pp. 43, 12 plates, 20 text-figures. Fascicle 2: Painted stone age pottery from the province of Honan, China. By T. J. Arne. 1925. pp. 40, 13 plates (six in colour), 63 text-figures. Fascicle 3: The human skeletal remains from the Sha Kuo T'un cave-deposit in comparison with those from Yang Shao Tsun and with recent north China skeletal material. By Davidson Black. 1925. pp. 120, 14 plates, 86 tables. - MEMOIRS OF THE GEOLOGICAL SURVEY OF CHINA. Series A, no. 5. Preliminary report on archaeological researches in Kansu. By J. G. Andersson. Pekin. 1925. pp. 56, 12 plates. - Volume 2 Issue 5
Easy-First Dependency Parsing with Hierarchical Tree LSTMs (2016)

We suggest a compositional vector representation of parse trees that relies on a recursive combination of recurrent-neural network encoders. To demonstrate its effectiveness, we use the representation as the backbone of a greedy, bottom-up dependency parser, achieving very strong accuracies for English and Chinese, without relying on external word embeddings. The parser’s implementation is available for download at the first author’s webpage.
STUDIES ON THE ABSORPTION AND DISTRIBUTION OF CHLORAMPHENICOL (1951)

Chloramphenicol is readily absorbed from the gastrointestinal tract. Peak serum levels, while usually reached within two hours, are occasionally not attained for six or more hours. In general absorption is markedly more rapid than in the case of aureomycin, which seems to be absorbed slowly over a period of several hours. Eleven mg./kg. body weight, which is an adequate single dose of aureomycin, in the case of chloramphenicol produces serum levels too low to be detected by the authors' method. Twenty-two mg./kg. produces two hour levels averaging 8.3 µg./cc. and 44 mg./kg. raises this level to a mean of 22 µg./cc. Rectal administration of perforated chloramphenicol capsules produces peak serum levels approximately one-fifth of those effected with comparable oral dosage. Diffusion of chloramphenicol into cerebrospinal fluid occurs readily and after a few days administration spinal fluid levels, in three cases, were approximately 50% of the serum levels. These data suggest that effective oral dosage of chloramphenicol ranges from 22 to 44 mg./kg./dose and that the antibiotic should be given at 6 to 8 hour intervals.
Contents of sugars, free amino acids and free 5?-nucleotides in mushrooms,Agaricus bisporus, during post-harvest storage (1999)

Common mushrooms, Agaricus bisporus (Lange) Imbach, were stored at 12 °C for 12 days and composition changes were examined during post-harvest storage. The contents of total sugars, mannitol and fructose decreased steadily during storage, whereas the content of other reducing sugars, excluding fructose, remained constant. The content of total free amino acids increased from 77.92 at day 0 to 140.57 g kg−1 at day 6, and then slightly increased to 151.65 g kg−1 at day 12. The contents of nine amino acids increased over time, of these glutamic acid was the most significant. The content of monosodium glutamate-like components increased from 22.67 at day 0 to 47.12 g kg−1 at day 12. However, the contents of sweet and bitter components increased comparably from 24.08 and 24.17 at day 0 to 47.15 and 50.75 g kg−1 at day 12, respectively. Total 5′-nucleotide content peaked at day 3. The contents of three flavour 5-nucleotides were high at days 3 and 6. © 1999 Society of Chemical Industry
3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts (2019)

Generation of thick vascularized tissues that fully match the patient still remains an unmet challenge in cardiac tissue engineering. Here, a simple approach to 3D-print thick, vascularized, and perfusable cardiac patches that completely match the immunological, cellular, biochemical, and anatomical properties of the patient is reported. To this end, a biopsy of an omental tissue is taken from patients. While the cells are reprogrammed to become pluripotent stem cells, and differentiated to cardiomyocytes and endothelial cells, the extracellular matrix is processed into a personalized hydrogel. Following, the two cell types are separately combined with hydrogels to form bioinks for the parenchymal cardiac tissue and blood vessels. The ability to print functional vascularized patches according to the patient's anatomy is demonstrated. Blood vessel architecture is further improved by mathematical modeling of oxygen transfer. The structure and function of the patches are studied in vitro, and cardiac cell morphology is assessed after transplantation, revealing elongated cardiomyocytes with massive actinin striation. Finally, as a proof of concept, cellularized human hearts with a natural architecture are printed. These results demonstrate the potential of the approach for engineering personalized tissues and organs, or for drug screening in an appropriate anatomical structure and patient-specific biochemical microenvironment.
Experimental results of thermally controlled superconducting switches for high frequency operation (1988)

As part of a study to develop thermally controlled switches for use in superconducting rectifiers operating at a few hertz and 1 kA, a theoretical model is presented of the thermal behavior of such a switch. The calculations are compared with experimental results of several switches having recovery times between 40 and 200 ms. A discussion is given of the maximum temperature T/sub N/ that occurs in the normal regions when the switch is in the resistive state. Once T/sub N/ is known, it is possible to predict the recovery time, activation energy, stationary dissipation and minimum propagation current. The calculated and measured results, in good agreement, show that T/sub N/ is approximately 12 K and largely independent of the thickness or material of the insulation layer. Mention is made of some problems, related to the room-temperature equipment which drives the rectifier, that so far have prevented the rectifiers from being used at their design specifications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>