gebhart/patrepeval huggingface dataset:
Stimulation of human neutrophil chemiluminescence by soluble immune complexes and antibodies to neutrophils. (1981)

Activation of the neutrophil surface membrane may occur with a variety of stimuli, leading to enhanced glucose oxidation via the hexose monophosphate shunt and production of toxic oxygen radicals such as superoxide anion. This metabolic stimulation may be accompanied by light emission or chemiluminescence. The objective of these studies was to determine the effects of soluble and insoluble immune complexes, IgG aggregates, and rabbit anti-neutrophil serum on neutrophil activation as measured by chemiluminescence. Also, the uptake of immune complexes by neutrophils was determined and was correlated with the solubility of the complexes and the levels of induced chemiluminescence. The results indicate that stimulation of neutrophil chemiluminescence and uptake of immune complexes by neutrophils were both closely correlated with the percent precipitation of the immune complexes. Insoluble immune complexes that were avidly ingested by neutrophils also stimulated maximum levels of chemiluminescence. Nevertheless, elevated levels of chemiluminescence were induced by soluble immune complexes that were poorly ingested by neutrophils. Similarly, soluble aggregated IgG induced elevated levels of neutrophil chemiluminescence in a dose-dependent manner. Aggregated IgG induced up to sixfold higher levels of neutrophil chemiluminescence than did equal amounts of monomeric IgG. Finally, rabbit anti-neutrophil serum also caused increased levels of neutrophil chemiluminescence. Since previous studies have shown that sera from some patients with rheumatoid arthritis and Felty's syndrome have increased amounts of neutrophil-binding IgG due to the presence of both immune complexes and neutrophil-reactive antibodies, the effect of these sera on neutrophil chemiluminescence was studied. Positive correlations were observed between the level of neutrophil chemiluminescence induced by the sera and the amount of serum IgG neutrophil-binding activity (r = 0.72, p less than 0.001) as well as the level of immune complexes determined by C1q binding (r = 0.76, p less than or equal to 0.001). Such neutrophil activation by immune complexes or antibodies may reflect production of toxic oxygen radicals and could subsequently affect neutrophil function.
Dendritic and cancer cells in the breast tumors--an immunohistochemical study: short communication. (2001)

Normal and dysplastic mammary glands express immunocompetent S-100 protein positive dendritic cells (DCs), which are located in a regular pattern, in the suprabasal cell layer of the ducts and alveolar nodules. The epithelial cells, however, are S-100 protein negative. Since some breast cancers also express the S-100 protein, our aim was to check the diagnostic and prognostic value of the S-100 protein distribution combined with the tumor grade and expression of synaptophysin (Syn), chromogranin A (Chg A), c-erbB-2 oncoprotein and p53 protein in infiltrating and metastatic breast tumors. Applying immunohistochemical methods, we show in paraffin- or frozen breast tissue sections that in some cases of the infiltrating breast carcinomas, S-100 protein positive cells do not appear, whereas in other cases, either S-100 protein positive DCs are closely associated with cancer cells, or the cancer cells themselves stain positive to S-100 protein. However, we found no correlation between the S-100 protein expression and other investigated parameters.
Freeform Fabrication of Electroactive Polymer Actuators and Electromechanical Devices (2004)

In pursuit of the goal of producing complete electromechanical systems entirely via solid freeform fabrication, we are developing a library of mutually compatible, functional, freeform elements. Several essential elements – actuation, sensing, and control electronics - still remain to be incorporated into this library. Conducting polymers (CP) are a class of materials which can be used to produce all of these functionalities. Meanwhile, research into actuatable “smart” materials has produced other candidate materials for freeform fabricated actuators that are compatible with our library. We have succeeded in manually producing air-operable actuators that have processing and operating requirements that are compatible with our power source and mechanical component library elements. A survey of candidate actuator materials is presented, experiments performed with two types of actuator materials are described, and complete SFF-producible actuator devices are demonstrated.
Laparoscopic colectomy (1993)

A multicenter retrospective study was undertaken to assess the efficacy and safety of laparoscopy in colon and rectal surgery. To minimize potential bias in interpretation of the results, all data were registered with an independent observer, who did not participate in any of the surgical procedures. Sixty-six patients underwent a laparoscopic procedure. Operations performed included sigmoid colectomy (19), right hemicolectomy (15), low anterior resection (6), colectomy with ileal pouch-anal anastomosis (IPAA) (5), and abdominoperineal resection (APR) (3). The conversion rate from laparoscopic colectomy to celiotomy was 41 percent. Major morbidity and mortality were 24 percent and 0 percent, respectively. Length of stay, hospital costs, and lymph node harvest were compared between the sigmoid resection and right hemicolectomy subgroups. Data from traditional sigmoid colectomies and right hemicolectomies were obtained from the same institutions for comparison. Mean postoperative stay for laparoscopically completed sigmoid and right colectomies was significantly less than that for either the converted or the traditional groups (P < 0.02). Total hospital cost for traditional right hemicolectomy was significantly less than that for the converted group (P < 0.05) but not the laparoscopic group. Laparoscopic sigmoid resection showed no significant total hospital cost difference among traditional, converted, and laparoscopic groups. Lymph node harvest in resections for carcinoma was comparable in all groups. These preliminary data suggest that laparoscopic colon and rectal surgery can be accomplished with acceptable morbidity and mortality when performed by trained surgeons. Length of stay is shorter, but there is no proven total hospital cost benefit. Appropriate registries will be necessary to adequately assess long-term outcome.
Forecasting high-dimensional data (2010)

We propose a method for forecasting high-dimensional data (hundreds of attributes, trillions of attribute combinations) for a duration of several months. Our motivating application is guaranteed display advertising, a multi-billion dollar industry, whereby advertisers can buy targeted (high-dimensional) user visits from publishers many months or even years in advance. Forecasting high-dimensional data is challenging because of the many possible attribute combinations that need to be forecast. To address this issue, we propose a method whereby only a sub-set of attribute combinations are explicitly forecast and stored, while the other combinations are dynamically forecast on-the-fly using high-dimensional attribute correlation models. We evaluate various attribute correlation models, from simple models that assume the independence of attributes to more sophisticated sample-based models that fully capture the correlations in a high-dimensional space. Our evaluation using real-world display advertising data sets shows that fully capturing high-dimensional correlations leads to significant forecast accuracy gains. A variant of the proposed method has been implemented in the context of Yahoo!'s guaranteed display advertising system.
The Promise of response to intervention: evaluating current science and practice (2011)

Glover, Supporting All Students: The Promise of Response to Intervention. Glover, Key RTI Service Delivery Components: Considerations for Research-informed Practice. Kovaleski, Black, Multi-tier Service Delivery: Current Status and Future Directions. Hintze, Marcotte, Student Assessment and Data-based Decision Making. Denton, Vaughn, Preventing and Remediating Reading Difficulties: Perspectives from Research. Wanzek, Vaughn, Research-based Implications from Extensive Early Reading Interventions. Reed, Vaughn, Reading Interventions for Older Students. Clarke, Gersten, Newman-Gonchar, RTI in Mathematics: Beginnings of a Knowledge Base. De La Paz, Espin, McMaster, RTI in Writing Instruction: Implementing Evidence-based Interventions and Evaluating the Effects for Individual Students. Ihlo, Nantais, Evidence-based Interventions within a Multi-tier Framework for Positive Supports. Burns, Christ, Boice, Szadokierski, Special Education in an RTI Model: Addressing Unique Learning Needs. Sugai, Horner, Fixsen, Blase, Developing Systems-level Capacity for RTI Implementation: Current Efforts and Future Directions.
An anticipatory fuzzy logic controller utilizing neural net prediction (1992)

The goal of this project was to evaluate control fuzzy logic for applicability to con trol of flexible structures. This was done by applying these methods to control of the Control Structures Interaction Suitcase Demonstrator developed at Marshall Space Flight Center. Both traditional and new anticipatory fuzzy logic schemes were applied to the system, and results were compared to that of the system with a standard Linear Quadratic Regulator as a controller. In order to perform the state prediction necessary to the anticipatory fuzzy logic controller, a neural network was trained to emulate the behavior of the system, based on input-output data for the system. Behavior of the controllers was compared under ideal conditions, under noisy conditions, and with randomly chosen state parameters perturbed by + or-50%. Fuzzy systems demonstrated robustness to added noise and to changes in plant parameters; the anticipatory fuzzy system exhibited superior performance when compared to both traditional fuzzy and LQR controller systems. The anticipatory fuzzy neural controller exhibits similar properties, but does not require that any mathematical model for the system exist. Thus it can be applied to many real world systems for which other control methods can not be used.
Overexpression of Interleukin-2 by a Recombinant Herpes Simplex Virus Type 1 Attenuates Pathogenicity and Enhances Antiviral Immunity (2002)

The expression of interleukin-2 (IL-2) has been implicated in the modulation of the outcome of ocular infection with herpes simplex virus type 1 (HSV-1); however, its effects remain controversial. To clarify the role of IL-2, we constructed a recombinant HSV-1 (HSV-IL-2) that expresses two copies of the murine IL-2 gene under the control of the latency-associated transcript (LAT) promoter of HSV-1 in a LAT-negative virus. In tissue culture, the replication of the HSV-IL-2 was 100-fold lower than that of the wild-type virus at a low multiplicity of infection (MOI). Addition of recombinant anti-IL-2 polyclonal antibody markedly enhanced HSV-IL-2 replication in tissue culture. In the 7-day period after ocular infection of BALB/c mice, the replication of HSV-IL-2 was significantly lower than that of wild-type virus in tear cultures, whole eyes, and brain, but was equivalent to wild-type replication in the trigeminal ganglia. Ocular challenge of BALB/c mice with HSV-IL-2 alone, at an MOI that resulted in only 13% survival when parental virus was used, was associated with 90% survival. This decrease in virulence was further shown to be attributable to the expression of IL-2 by coinfection of mice with HSV-IL-2 and the parental virus. This resulted in a decrease in virulence of the parental virus (5% survival when administered alone versus 50% survival on coinfection with HSV-IL-2). The survival of HSV-IL-2-infected mice was compromised by depletion of either IL-2, CD4(+), or CD8(+) T cells (50% survival) and abolished completely by depletion of both T-cell subtypes. Moreover, depletion of CD4(+) T cells, CD8(+) T cells, or both increased the titers of HSV-IL-2 in the tears, eyes, trigeminal ganglia, and brains of infected mice, so that titers were equivalent to or higher than that of the parental virus. These results suggest that IL-2 expression by recombinant HSV-1 reduces virulence and that depletion of IL-2 or T cells increases virulence in HSV-1-infected mice.
Intramolecular cyclization of allylsilanes in the synthesis of guaian-8,12-olide. Stereoselective formation of trans- and cis-fused methylenelactones (1994)

One-step formation of guaian-8,12-olide derivatives, α-methylene-γ-lactones fused to a perhydroazulene carbon framework with various stereochemistries, were performed from monocyclic compounds via intramolecular cyclization of ω-formyl-α-trimethylsilylmethyl-α,β-unsaturated esters. Stereochemical features of both Lewis acid- and fluoride-promoted cyclizations are discussed.
The ability of tumor volume to predict local control in surgically treated squamous cell carcinoma of the supraglottic larynx (2000)

Pretreatment CT volumetric analysis is useful for predicting local control in patients with SGSCCA carcinoma treated surgically.
Determination of the glass transition of polymer by the autovibron (1982)

Abstract The automated Rheovibron (Autovibron) has been useful for determining the glass transition behavior of polymers. The standard (manual Rheovibron viscoelastometer has been used sufficiently small intervals, and so, some accuracy on transition location must be sacrificed when the temperature intervals are taken 5 to 10°C apart. However, the Autovibron can be observed over very small temperature intervals (<1.5°C)), which essentially provide a continous monitoring of the changes in storage modulus, loss modulus, and tan δ. An improved accuracy and sensitivity of the Autovibron are provided by a combination of multiprogrammer, programmable calculator, and lock‐in analyzer. The Autovibron are provided by a combination of multiprogrammer, programmable calculator, and lock‐in analyzer. The Autovibron shows a good capability for dynamic thermomechanometry. The glass transition bility for dynamic thermomechnometry. The glass transition of polymers can be determined by analyzing the loss tangent peak. The maximum value in loss tangent, peak temperature, and the newly introduced terms, Δ T 1 and Δ T 2 which indicate the widths of tan δ peak, are useful indicators of the glass transition. The Δ T 1 and Δ T 2 show the distribution of the glass transition and are related to order and crystallinity in the structure.
Comparison of Four Markers of Intestinal Permeability in Control Subjects and Patients with Coeliac Disease (1994)

Correlations of marker permeation rates with test dose osmolarity in controls and patients with coeliac disease shows a variable lack of conformity, suggesting that the markers may permeate the intestine by different routes, which are affected to a different extent in coeliac disease.
Numerical study of induced current perturbations in the vicinity of excitable cells exposed to extremely low frequency magnetic fields (2003)

Realistic three-dimensional cell morphologies were modelled to determine the current density induced in excitable cell culture preparations exposed to 60 Hz magnetic fields and to identify important factors that can influence the responses of cells to these fields. Cell morphologies representing single spherical adrenal chromaffin cells, single elongated smooth muscle cells and chromaffin cell aggregates in a Petri dish containing culture medium were modelled using the finite element method. The computations for a spherical cell revealed alterations in the magnitude and spatial distribution of the induced current density in the immediate vicinity of the cell. Maxima occurred at the equatorial sides and minima at the poles. Proximity of cells to each other as well as cell aggregate shape, size and orientation with respect to the induced current influenced the magnitude and spatial distribution of the induced current density. For an elongated cell, effects on the induced current density were highly dependent on cell orientation with respect to the direction of the induced current. These results provide novel insights into the perturbations in induced current that occur in excitable cell culture preparations and lay a foundation for understanding the mechanisms of interaction with extremely low frequency magnetic fields at the tissue level.
On the Composition of the Seeds of Martynia Louisiana. (1915)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the Composition of the Seeds of Martynia Louisiana.E. H. S. Bailey and W. S. LongCite this: Ind. Eng. Chem. 1915, 7, 10, 867–868Publication Date (Print):October 1, 1915Publication History Published online1 May 2002Published inissue 1 October 1915https://pubs.acs.org/doi/10.1021/ie50082a019https://doi.org/10.1021/ie50082a019research-articleACS PublicationsRequest reuse permissionsArticle Views8Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Microwave absorbing screens based on multilayered Fe nanofilms (2010)

In this paper, a new microwave absorbing screen is fabricated with multilayered Fe-SiO 2 nanofilms deposited on flexible polyimide substrate. Using the transmission line model, the design of the absorbing screen is optimized. The microwave absorption of the optimized structure is verified by experiments, which are in good agreement with the transmission line analysis. Owing to the electrical and magnetic damping of the Fe nanofilms, the total thickness of the structure including face sheet and foam spacer is about one seventh of the resonant wavelength in free space. The absorbing screen is light weighted due to the thin face sheet and foam spacer, which results in a surface density of only 0.29 kg/m2. This kind of screen could be designed to work at different microwave frequency and used in different electromagnetic compatibility or interference reduction applications.
Loss of PTEN Expression by Blocking Nuclear Translocation of EGR1 in Gefitinib-Resistant Lung Cancer Cells Harboring Epidermal Growth Factor Receptor–Activating Mutations (2010)

Gefitinib (Iressa) and erlotinib (Tarceva), which target the epidermal growth factor receptor (EGFR), are approved for treatment of patients with advanced non-small cell lung cancer (NSCLC). Patients whose tumors harbor mutations in the EGFR gene, including delE746-A750 in exon 19 and L858R in exon 21, may benefit in particular from gefitinib treatment. However, acquired resistance to gefitinib has been a serious clinical problem, and further optimization is needed for application of EGFR-targeted drugs in lung cancer patients. In this study, we established gefitinib-resistant NSCLC cells from PC-9 cell line, which harbors the delE746-A750 mutation, by exposing the cell line to gefitinib for over 7 months. Gefitinib-resistant PC-9/GEFs cell lines showed a marked downregulation of PTEN expression and increased Akt phosphorylation. In revertant, gefitinib-sensitive clones (PC-9/Rev) derived from PC-9/GEF1-1 and PC-9/GEF2-1, PTEN expression, as well as sensitivity to gefitinib and erlotinib, was restored. Knockdown of PTEN expression using small interfering RNA specific for PTEN in PC-9 cells resulted in drug resistance to gefitinib and erlotinib. Nuclear translocation of the EGR1 transcription factor, which regulates PTEN expression, was shown to be suppressed in resistant clones and restored in their revertant clones. Reduced PTEN expression was also seen in tumor samples from a patient with gefitinib-refractory NSCLC. This study thus strongly suggests that loss of PTEN expression contributes to gefitinib and erlotinib resistance in NSCLC. Our findings reinforce the therapeutic importance of PTEN expression in the treatment of NSCLC with EGFR-targeted drugs.
Efficient management of time-evolving databases (1995)

Efficiently managing the history of a time-evolving system is one of the central problems in many database environments, like database systems that incorporate versioning, or object-oriented databases that implicitly or explicitly maintain the history of persistent objects. In this paper we propose algorithms that reconstruct past states of an evolving system for two general cases, i.e., when the system's state is represented by a set or by a hierarchy (a forest of trees). Sets are widely used as a canonical form of representing information in databases or program states. For more complex applications, like schema evolution in object-oriented databases, it becomes necessary to manage the history of data structures that have the form of forests or even graphs. The proposed algorithms use minimal space (proportional to the number of changes occurring in the evolution) and have the advantage of being on-line (in the amortized sense). Any past system state s(t) is reconstructed in time O.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Viewpoint Integration for Hand-Based Recognition of Social Interactions from a First-Person View (2015)

Wearable devices are becoming part of everyday life, from first-person cameras (GoPro, Google Glass), to smart watches (Apple Watch), to activity trackers (FitBit). These devices are often equipped with advanced sensors that gather data about the wearer and the environment. These sensors enable new ways of recognizing and analyzing the wearer's everyday personal activities, which could be used for intelligent human-computer interfaces and other applications. We explore one possible application by investigating how egocentric video data collected from head-mounted cameras can be used to recognize social activities between two interacting partners (e.g. playing chess or cards). In particular, we demonstrate that just the positions and poses of hands within the first-person view are highly informative for activity recognition, and present a computer vision approach that detects hands to automatically estimate activities. While hand pose detection is imperfect, we show that combining evidence across first-person views from the two social partners significantly improves activity recognition accuracy. This result highlights how integrating weak but complimentary sources of evidence from social partners engaged in the same task can help to recognize the nature of their interaction.