gebhart/patrepeval huggingface dataset:
Degenerate critical coupling in all-dielectric metasurface absorbers (2017)

We develop the theory of all-dielectric absorbers based on temporal coupled mode theory (TCMT), with parameters extracted from eigenfrequency simulations. An infinite square array of cylindrical resonators embedded in air is investigated, and we find that it supports two eigenmodes of opposite symmetry that are each responsible for half of the total absorption. The even and odd eigenmodes are found to be the hybrid electric (EH<sub>111</sub>) and hybrid magnetic (HE<sub>111</sub>) waveguide modes of a dielectric wire of circular cross section, respectively. The geometry of the cylindrical array is shown to be useful for individual tuning of the radiative loss rates of the eigenmodes, thus permitting frequency degeneracy. Further, by specifying the resonators' loss tangent, the material loss rate can be made to equal the radiative loss rate, thus achieving a state of degenerate critical coupling and perfect absorption. Our results are supported by S-parameter simulations, and agree well with waveguide theory.
Conversion of Bacteriorhodopsin into a Chloride Ion Pump (1995)

In the light-driven proton pump bacteriorhodopsin, proton transfer from the retinal Schiff base to aspartate-85 is the crucial reaction of the transport cycle. In halorhodopsin, a light-driven chloride ion pump, the equivalent of residue 85 is threonine. When aspartate-85 was replaced with threonine, the mutated bacteriorhodopsin became a chloride ion pump when expressed in Halobacterium salinarium and, like halorhodopsin, actively transported chloride ions in the direction opposite from the proton pump. Chloride was bound to it, as revealed by large shifts of the absorption maximum of the chromophore, and its photointermediates included a red-shifted state in the millisecond time domain, with its amplitude and decay rate dependent on chloride concentration. Bacteriorhodopsin and halorhodopsin thus share a common transport mechanism, and the interaction of residue 85 with the retinal Schiff base determines the ionic specificity.
Meniscal allograft transplantation: long‐term clinical results with radiological and magnetic resonance imaging correlations (2006)

Long-term data on the clinical outcome and the fate of the meniscus allograft after transplantation are scarce. In this study we present the clinical, radiological and MRI outcome of the meniscus graft and the articular cartilage after 42 meniscus allograft transplantations in 41 patients with a minimum follow-up of 10 years. A total of 27 medial and 15 lateral meniscal allografts were transplanted. Eleven of the medial allograft procedures were associated with a high tibial osteotomy. The patients were evaluated clinically at the time of transplantation and at the final follow-up using the modified HSS scoring system. The knee injury and osteoarthritis outcome score (KOOS) was used as an evaluation tool for patient-related outcome at the final follow-up. Joint space width narrowing and Fairbank changes were radiological outcome parameters, which were available for 32 patients. Femoral and tibial cartilage degeneration, graft extrusion and signal intensity were scored on MRI scans obtained in 17 patients approximately 1 year after transplantation and at the final follow-up (>10 years). For statistical analysis the patients were divided into three groups: lateral meniscal allograft (LMT), medial meniscal allograft transplantation with a high tibial osteotomy (MMT+HTO) and without (MMT). The modified HSS score revealed a significant improvement in pain and function at the final follow-up for all groups. Further analysis also revealed that an MMT+HTO procedure resulted in a greater improvement at the final follow-up when compared to MMT. Nonetheless, the KOOS scores obtained at the final follow-up revealed the presence of substantial disability and symptoms, in addition to a reduced quality of life. Radiographical analysis revealed no further joint space narrowing in 13/32 knees (41%). Fairbank changes remained stable in 9/32 knees (28%). MRI analysis showed no progression of cartilage degeneration in 6/17 knees (35%). An increased signal intensity of the allograft was present, as was partial graft extrusion in the majority of patients at the final follow-up. Seven cases had to be converted to a total knee arthroplasty during the follow-up; the overall failure rate was 18%. Long-term results after viable meniscus allograft transplantation are encouraging in terms of pain relief and improvement of function. Despite this significant improvement, substantial disability and symptoms were present in all investigated subgroups. Progression of further cartilage degeneration or joint space narrowing was absent in a considerable number of cases, indicating a potential chondroprotective effect. Level of evidence is therapeutic study, Level IV and retrospective analysis of prospectively collected data.
Modic Changes in Endplates of Lumbar Vertebral Bodies (2007)

Modic changes at L5-S1 and Modic type I lesions are more likely to be associated with pain symptoms than other types of Modic changes or changes located at other lumbar levels.
Biochemical Characterization of Alzheimer's Soluble Amyloid Beta Protein in Human Cerebrospinal Fluid: Association with High Density Lipoproteins (1996)

The soluble form of Alzheimer's amyloid beta protein (sA beta) is associated with high density lipoproteins (HDL) in normal human plasma (BBRC, 1994, 205, 1164-1171). Since sA beta is also present in cerebrospinal fluid (CSF) and the lipoprotein pattern of CSF is different from that of plasma, it was of interest to ascertain whether the interaction of sA beta with HDL also occurs in CSF. Normal human CSF lipoproteins were obtained by sequential flotation ultracentrifugation and analyzed for the presence of sA beta via immunoblot, size-exclusion chromatography, immunoelectron microscopy, N-terminal sequence and mass-spectrometry analyses. Soluble A beta was associated with CSF-HDL particles of 16.8 +/- 3.2 nm in diameter and approximately 200 kDa of relative molecular mass. A approximately 4.3 kDa component purified by HPLC was immunoreactive with anti-A beta antibodies and exhibited an N-terminal sequence identical to the A beta peptide with a mass of 4325.1 Da, indicating that the main sA beta specie associated with CSF-HDL is A beta 1-40.
Mutagenesis and expression of methane monooxygenase to alter regioselectivity with aromatic substrates (2017)

Soluble methane monooxygenase (sMMO) from methane-oxidising bacteria can oxygenate more than 100 hydrocarbons and is one of the most catalytically versatile biological oxidation catalysts. Expression of recombinant sMMO has to date not been achieved in Escherichia coli and so an alternative expression system must be used to manipulate it genetically. Here we report substantial improvements to the previously described system for mutagenesis of sMMO and expression of recombinant enzymes in a methanotroph (Methylosinus trichosporium OB3b) expression system. This system has been utilised to make a number of new mutants and to engineer sMMO to increase its catalytic precision with a specific substrate whilst increasing activity by up to 6-fold. These results are the first 'proof-of-principle' experiments illustrating the feasibility of developing sMMO-derived catalysts for diverse applications.
SPLIT TOLERANCE INDUCED BY IMMUNOTOXIN IN A RHESUS KIDNEY ALLOGRAFT MODEL1 (1997)

These data suggest that FN18-CRM9 treatment of rhesus monkeys allows the development of specific down-regulation of antidonor CTL activity in renal allograft recipients.
The structure of (xylose)2glucose-O-serine 53 found in the first epidermal growth factor-like domain of bovine blood clotting factor IX. (1990)

We reported the presence of a new trisaccharide composed of two xylose and reducing terminal glucose residues linked to serine residues of bovine blood clotting factors VII and IX (Hase, S., Kawabata, S., Nishimura, H., Takeya, H., Sueyoshi, T., Miyata, T., Iwanaga, S., Takao, T., Shimonishi, Y., and Ikenaka, T. (1988) J. Biochem. (Tokyo) 104, 867-868). The present paper describes the detailed structural analysis of the trisaccharide. Glycopeptides were prepared from bovine factor IX by digestion with Pronase followed by purification by column chromatography. The trisaccharide was released from the protein by the beta-elimination reaction with hydrazine, and the reducing end of the sugar chain was tagged with 2-aminopyridine. The fluorescent pyridylamino derivative of the trisaccharide was purified by gel filtration and reversed-phase high performance liquid chromatography. The glycopeptides and pyridylamino-trisaccharide thus obtained were subjected to methylation study, 500-MHz 1H nuclear magnetic resonance spectroscopy, and periodate oxidation. Glucose and xylose belong to the D series by high performance liquid chromatography on a chiral column. From the results, the structure of the trisaccharide is proposed as: D-Xyl p alpha 1-3-D-Xyl p alpha 1-3-D-Glcp beta 1-O-Ser-53.
Determination of silicon in titanium dioxide and zirconium dioxide by electrothermal atomic absorption spectrometry using the slurry sampling technique (1994)

A method for the determination of silicon in titanium dioxide and zirconium dioxide powders based on electrothermal atomic absorption spectrometry using the slurry sampling technique has been developed. The experimental conditions with regard to chemical modification, the temperature programme, the lifetime of the graphite furnace and the slurry concentration were optimized. The behaviour of zirconium and calcium in the graphite tube during the ashing, atomization and cleaning steps was investigated using 47Ca and 97Zr as radiotracers. Calibration was performed by the standard additions method using aqueous standards. The results of this technique were compared with those for atomic emission spectrometry. The limits of detection were found to be 7 µg g–1 in titanium dioxide and 2 µg g–1 in zirconium dioxide, respectively.
The CD4+ T cell immunodominant <i>Anaplasma marginale</i> major surface protein 2 stimulates γδ T cell clones that express unique T cell receptors (2004)

Major surface protein 2 (MSP2) of the bovine rickettsial pathogen Anaplasma marginale is an abundant, serologically immunodominant outer membrane protein. Immunodominance partially results from numerous CD4+ T cell epitopes in highly conserved amino and carboxy regions and the central hypervariable region of MSP2. However, in long-term cultures of lymphocytes stimulated with A. marginale, workshop cluster 1 (WC1)+ gammadelta T cells and CD4+ alphabeta T cells proliferated, leading to a predominance of gammadelta T cells. As gammadelta T cells proliferate in A. marginale-stimulated lymphocyte cultures, this study hypothesized that gammadelta T cells respond to the abundant, immunodominant MSP2. To test this hypothesis, gammadelta T cell clones were isolated from MSP2 vaccinates and assessed for antigen-specific proliferation and interferon-gamma secretion. Seven WC1+ gammadelta T cell clones responded to A. marginale and MSP2, and three of these proliferated to overlapping peptides from the conserved carboxy region. The gammadelta T cell response was not major histocompatibility complex-restricted, although it required antigen-presenting cells and was blocked by addition of antibody specific for the T cell receptor (TCR). Sequence analysis of TCR-gamma and -delta chains of peripheral blood lymphocytes identified two novel TCR-gamma chain constant (Cgamma) regions. It is important that all seven MSP2-specific gammadelta T cell clones used the same one of these novel Cgamma regions. The TCR complementarity-determining region 3 was less conserved than those of MSP2-specific CD4+ alphabeta T cell clones. Together, these data indicate that WC1+ gammadelta T cells recognize A. marginale MSP2 through the TCR and contribute to the immunodominant response to this protein.
Experiments on Rearing the Barnacle <i>Elminius modestus</i> Darwin to the Settling Stage in the Laboratory (1960)

Nauplii from freshly collected adults were fed with the diatom Phaeodactylum tricornutum Bohlin and dried liver powder in mass culture tanks. Details of the method of preparation of food, design of the tank, rate of flow of sea-water, and population densities are given. Low but consistent yields (0.02-3.80 per cent.) of settling cyprids were obtained, the total from five consecutive experiments being 3431. At the locality (Menai Straits, Sorth Wales) natural settling of Elminius modestus Darwin took place in the summer months (May-September) with a main peak about June-July. The above experiments were made during winter (December-March) when natural settling was not detected on exposure plates immersed concurrently in the sea amongst adults of this species.
Purification and properties of a new enzyme, N, N-dimethylarginine dimethylaminohydrolase, from rat kidney (1989)

A new enzyme, NG, NG-dimethylarginine dimethylaminohydrolase which plays a role in the metabolism of NG,NG-dimethyl-L-arginine, has been purified to homogeneity from rat kidney. The enzyme consists of a single polypeptide and its molecular weight is about 33,000. The isoelectric point of the enzyme is at pH 5.2. The enzyme catalyzes the hydrolytic liberation of the dimethylamino moiety of NG,NG-dimethyl-L-arginine and forms L-citrulline and dimethylamine. It is highly specific for NG,NG-dimethyl-L-arginine and NG-monomethyl-L-arginine, and the Km values for these amino acids are 0.18 and 0.36 mM, respectively. The enzyme shows the maximum activity at pH 6.5 and requires no cofactor. The activity is strongly inhibited by SH-blocking reagents (e.g. p-chloromercuribenzoate and HgCl2) and divalent metal ions (e.g. Cd2+, Cu2+, and Zn2+).
Stretchable Ag electrodes with mechanically tunable optical transmittance on wavy-patterned PDMS substrates (2017)

We report on semi-transparent stretchable Ag films coated on a wavy-patterned polydimethylsiloxane (PDMS) substrate for use as stretchable electrodes for stretchable and transparent electronics. To improve the mechanical stretchability of the Ag films, we optimized the wavy-pattern of the PDMS substrate as a function of UV-ozone treatment time and pre-strain of the PDMS substrate. In addition, we investigated the effect of the Ag thickness on the mechanical stretchability of the Ag electrode formed on the wavy-patterned PDMS substrate. The semi-transparent Ag films formed on the wavy-patterned PDMS substrate showed better stretchability (strain 20%) than the Ag films formed on a flat PDMS substrate because the wavy pattern effectively relieved strain. In addition, the optical transmittance of the Ag electrode on the wavy-patterned PDMS substrate was tunable based on the degree of stretching for the PDMS substrate. In particular, it was found that the wavy-patterned PDMS with a smooth buckling was beneficial for a precise patterning of Ag interconnectors. Furthermore, we demonstrated the feasibility of semi-transparent Ag films on wavy-patterned PDMS as stretchable electrodes for the stretchable electronics based on bending tests, hysteresis tests, and dynamic fatigue tests.
The Impact of Multi Sector Planning and New Working Procedures on Controller Tasks (2006)

A workload reduction can only be achieved if the underlying operational concept ensures the best use of provided tools. In various ATM research projects multi sector planning has been identified as a key enabler to increase en-route productivity and capacity for the European ATM system. This paper describes the development of three multi sector planning concept configurations including an associated controller task matrix that provides an overview of changing task responsibilities and thus potential areas of workload decrease for the controller. The paper conclude that the introduction of multi sector planning is possible under all simulated traffic situations if a clear distribution of tasks and responsibilities between the controller team is introduced and the required redundancy for supervision of traffic is maintained.
Detecting geomagnetic pulsations using a solenoid with a ferrite core (1978)

To monitor geomagnetic pulsations at the southern auroral zone station, Macquarie Island, a sensor consisting of a solenoid wound on a ferrite core was used. The design of the sensor and a suitable preamplifier and their field operation and calibration are described.
An integrative view of the pathophysiological events leading to cisplatin nephrotoxicity (2011)

Cisplatin is among the most effective chemotherapeutic agents against solid tumors. Nephrotoxicity is the most common side effect of cisplatin chemotherapy, which limits the clinical use of cisplatin and seriously worsens the quality of life of cancer patients resulting in dosage reduction and discontinuation of treatment. Cisplatin involves a complex multifactorial process, as it has direct toxic effect on cells of the renal tubules, vasculature and glomeruli, and causes alterations in renal blood flow and glomerular filtration rate. Indirectly, cisplatin also induces inflammation of the renal interstitium, which contributes to the acute damage and may lead to chronic interstitial fibrosis, indicative of irreversible renal damage. This review presents an integrative view of the pathophysiological effects of cisplatin on tubular, vascular, glomerular, and interstitial function and the interplay among these actions. Moreover, it reviewed human clinical trials of the last ten years in order to evaluate the incidence and severity of the renal injury induced by cisplatin at the doses and therapeutic guidelines used in the clinical practice.
Expression of Interleukin-18 in Human Atherosclerotic Plaques and Relation to Plaque Instability (2001)

These results suggest, for the first time, a major role for IL-18 in atherosclerotic plaque destabilization leading to acute ischemic syndromes.
Prognostic Factors for Persistent or Recurrent Disease of Papillary Thyroid Carcinoma with Neck Lymph Node Metastases and/or Tumor Extension beyond the Thyroid Capsule at Initial Diagnosis (2005)

Context: Reliable prognostic factors are needed in papillary thyroid cancer patients to adapt initial therapy and follow-up schemes to the risks of persistent and recurrent disease. Objective and Settings: To evaluate the respective prognostic impact of the extent of lymph node (LN) involvement and tumor extension beyond the thyroid capsule, we studied a group of 148 consecutive papillary thyroid cancer patients with LN metastases and/or extrathyroidal tumor extension. Initial treatment, performed at the Institut Gustave Roussy between 1987 and 1997, included in all patients a total thyroidectomy with central and ipsilateral en bloc neck dissection followed by radioactive iodine ablation. Results: Uptake outside the thyroid bed, demonstrating persistent disease, was found on the postablation total body scan (TBS) in 22% of the patients. With a mean follow-up of 8 yr, eight patients (7%) with a normal postablation TBS experienced a recurrence. Ten-year disease-specific survival rate was 99% (confidence interval, 97–100%). Significant risk factors for persistent disease included the numbers of LN metastases (&gt;10) and LN metastases with extracapsular extension (ECE-LN &gt;3), tumor size (&gt;4 cm), and LN metastases location (central). Significant risk factors for recurrent disease included the numbers of LN metastases (&gt;10), ECE-LN (&gt;3), and thyroglobulin level measured 6–12 months after initial treatment after T4 withdrawal. Conclusion: We highlight an excellent survival rate and suggest risk classifications of persistent and recurrent disease based on the numbers of LN metastases and ECE-LN, LN metastases location, tumor size, and thyroglobulin level.
THE DETERMINATION OF METHANE AND HYDROGEN BY EXPLOSION.<sup>1</sup> (1895)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE DETERMINATION OF METHANE AND HYDROGEN BY EXPLOSION.1Augustus H. Gill and Samuel P. HuntCite this: J. Am. Chem. Soc. 1895, 17, 12, 986–994Publication Date (Print):December 1, 1895Publication History Published online1 May 2002Published inissue 1 December 1895https://pubs.acs.org/doi/10.1021/ja02167a014https://doi.org/10.1021/ja02167a014research-articleACS PublicationsRequest reuse permissionsArticle Views36Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Near-surface Traveltime Tomographic Inversion Using Multiple first Break Picks (2013)

The input data for refraction traveltime tomography are the traveltimes of the first breaks, which are picked using automatic pickers. Although automatic pickers perform satisfactorily overall, no one automatic picker can be characterized as the best one; one picker might fail for traces for which other pickers are accurate and vice versa for other traces. We introduce an iterative method for traveltime tomography, which takes as input traveltimes from a number of pickers. During the inversion scheme inconsistent traveltimes are replaced with more meaningful ones to obtain a smooth near-surface velocity model. The scheme is easily parallelizable and a byproduct of the inversion scheme is a set of consistent traveltimes which is close to the actual traveltimes of the first breaks.
Cryptography in the Bounded Quantum Storage Model (2005)

We initiate the study of two-party cryptographic primitives with unconditional security, assuming that the adversary's <em> quantum</em> memory is of bounded size. We show that oblivious transfer and bit commitment can be implemented in this model using protocols where honest parties need no quantum memory, whereas an adversarial player needs quantum memory of size at least n/2 in order to break the protocol, where n is the number of qubits transmitted. This is in sharp contrast to the classical bounded-memory model, where we can only tolerate adversaries with memory of size quadratic in honest players' memory size. Our protocols are efficient, non-interactive and can be implemented using today's technology. On the technical side, a new entropic uncertainty relation involving min-entropy is established.