gebhart/patrepeval huggingface dataset:
The 1979 world administrative radio conference (1979)

This September in Geneva the International Telecommunication Union (ITU) will convene a World Administrative Radio Conference called WARC-79. The purpose of this gathering is to review and revise where necessary essentially all the International Radio Regulations, so that the benefits of wireless communication may be equitably shared and enjoyed by all the world’s inhabitants. The increasing importance of telecommunications cannot be overemphasized; fast, reliable communication is essential to the economic, political and social well-being of modern nations. The treaty formulated at WARC-79 will represent the cooperative effort of the 154 member nations of the ITU to ensure the
Cardiomyopathy in Friedreich Ataxia (2012)

Friedreich ataxia is the most common human ataxia and results from inadequate production of the frataxin protein, most often the result of a triplet expansion in the nuclear FXN gene. The gene cannot be transcribed to generate the messenger ribonucleic acid for frataxin. Frataxin is an iron-binding protein targeted to the mitochondrial matrix. In its absence, multiple iron-sulfur-dependent proteins in mitochondria and the cytosol lack proper assembly, destroying mitochondrial and nuclear function. Mitochondrial oxidant stress may also participate in ongoing cellular injury. Although progressive and debilitative ataxia is the most prominent clinical finding, hypertrophic cardiomyopathy with heart failure is the most common cause of early death in this disease. There is no cure. In this review the authors cover recent basic and clinical findings regarding the heart in Friedreich ataxia, offer recommendations for clinical management of the cardiomyopathy in this disease, and point out new research directions to advance the field.
Joint source-channel matching for a wireless communications link (2002)

Application of joint source-channel matching in heterogeneous multimedia environments will demand general source-channel optimization schemes suitable for a wide variety of source coding standards, channel coders, and variable channel conditions. We develop a general approach for joint source-channel matching based on a parametric distortion model that can be accurately applied to most classes of source and channel coders. Our simulations indicate that it may be possible to obtain nearly all of the benefits of joint source-channel optimization by matching existing source and channel coding standards using the simple and general approach we propose.
Data Transfers between Processes in an SMP System: Performance Study and Application to MPI (2006)

This paper focuses on the transfer of large data in SMP systems. Achieving good performance for intranode communication is critical for developing an efficient communication system, especially in the context of SMP clusters. We evaluate the performance of five transfer mechanisms: shared-memory buffers, message queues, the Ptrace system call, kernel module-based copy, and a high-speed network. We evaluate each mechanism based on latency, bandwidth, its impact on application cache usage, and its suitability to support MPI two-sided and one-sided messages
Probabilistic teleportation of a three-particle state via three pairs of entangled particles (2003)

A scheme for teleporting an arbitrary three-particle state is proposed when three pairs of entangled particles are used as quantum channels. Quantum teleportation can be successfully realized with a certain probability if the receiver adopts an appropriate unitary-reduction strategy. The probability of successful teleportation is determined by the smallest coefficients of the three entangled pairs.
Apnea Detecting Sensors (2006)

This paper deals with the detection of sleep apnea. Even though many instruments are developed in the detection of sleep apnea, it's not much reliable. This is because these instruments use only a single sensor for detecting apnea. So there is a great need to design a proper instrument which will detect sleep apnea with great reliability. This can be accomplished by using three sensors instead of one. Those sensors which I have used for detection and respiration monitoring are microphone sensor, opto-electronic abdominal sensor and pulse plethysmographic sensor. The principle and basic block diagram for each type of sensor is used. The idea is to include all these sensors in a single respiration monitoring device to gain advantage of each sensor in a single respiration monitoring device to gain the advantage of each sensor and that of multiple sensors which is discussed at the end of paper.
Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes. (1980)

We have determined the entire sequence of two immunoglobulin kappa variable region genes derived separately from embryonic and plasmacytoma cells. Both genes are in the germline configuration; both are organized into hydrophobic leader and mature V-region coding sequences separated by a short intervening sequence. Both are identical with one another throughout the 1360 bases determined. In addition, there is a simple repeat sequence of 31 CA doublets that occurs about 300 bases from the 3' side of the coding sequence in each gene.
Synthesis, Policy Lessons, and Open Questions (1993)

Abstract This chapter returns to a number of common issues that emerged from the cumulative experience reviewed in previous chapters, considers open theoretical questions, and discusses some of the policy lessons. It looks at some of the theoretical arguments that have been suggested to explain the long delays in the adoption of stabilization programmes. It asks whether a universal paradigm has emerged on the necessary basic components of stabilization and structural reform programmes. It then broadens the question by asking if any generalizable lessons can be learned on the optimal sequencing of the various components of reform and whether there exists a real choice between ‘big bang’ and gradualist stabilization and reform strategies.
Experiment and mathematical modeling of gene expression dynamics in a cell-free system (2012)

Cell-free in vitro expression is increasingly important for high-throughput expression screening, high yield protein production and synthetic biology applications. Yet its potential for quantitative investigation of gene expression and regulatory circuits is limited by the availability of data on composition, kinetic rate constants and standardized computational tools for modeling. Here we report on calibration measurements and mathematical modeling of a reconstituted in vitro expression system. We measured a series of GFP expression and mRNA transcription time courses under various initial conditions and established the translation step as the bottle neck of in vitro protein synthesis. Cell-free translation was observed to expire after 3 h independent of initial template DNA concentration. We developed a minimalistic rate equation model and optimized its parameters by performing a concurrent fit to measured time courses. The model predicts the dependence of protein yield not only on template DNA concentration, but also on experimental timing and hence is a valuable tool to optimize yield strategies.
PROGNOSTIC VALUE OF A T HELPER 1 URINARY CYTOKINE RESPONSE AFTER INTRAVESICAL BACILLUS CALMETTE-GUERIN TREATMENT FOR SUPERFICIAL BLADDER CANCER (2002)

Urinary IL-2 levels may serve to identify patients at risk for bladder cancer recurrence after a single course of BCG and, thus, to tailor individual treatment.
Closed-form of the power spectral density for full response M-ary CPFSK modulation (2002)

A special method of analyzing the spectral properties of M-ary CPFSK (continuous-phase frequency shift keying) for full response signaling is presented. The autocorrelation function is presented in closed form, thereby avoiding truncation. A new transient component of the autocorrelation function is reported. The Fourier transform is used to find the power spectral density (PSD) function, which is also expressed in closed form. The effects of the system parameters, i.e., the M size of the alphabet, the modulation index, etc., on the system bandwidth and PSD are analyzed. The conditions under which the spectrum contains discrete lines are outlined. The continuous part of PSD is expressed in exponential form. A large number of PSDs have been computed and plotted in a relatively short time and are presented. Interesting results about both PSD and bandwidth are obtained for different choices of system parameters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Genetic dissection of the <i>miR-17∼92</i> cluster of microRNAs in Myc-induced B-cell lymphomas (2009)

The miR-17 approximately 92 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA). miR-17 approximately 92 is a direct transcriptional target of c-Myc, and experiments in a mouse model of B-cell lymphomas have shown cooperation between these two oncogenes. However, both the molecular mechanism underlying this cooperation and the individual miRNAs that are responsible for it are unknown. By using a conditional knockout allele of miR-17 approximately 92, we show here that sustained expression of endogenous miR-17 approximately 92 is required to suppress apoptosis in Myc-driven B-cell lymphomas. Furthermore, we show that among the six miRNAs that are encoded by miR-17 approximately 92, miR-19a and miR-19b are absolutely required and largely sufficient to recapitulate the oncogenic properties of the entire cluster. Finally, by combining computational target prediction, gene expression profiling, and an in vitro screening strategy, we identify a subset of miR-19 targets that mediate its prosurvival activity.
Identification of induction motor speed using neural networks (2002)

A newly developed approach to identify the mechanical speed of an induction motor based on the neural networks technique is described. The backpropagation neural network technique is used to provide a real-time adaptive estimation of the motor speed. The error between the desired state variable and the actual one is backpropagated to adjust the rotor speed, so that the actual state variable will coincide with the desired one. The backpropagation mechanism is easy to derive and the estimated speed tracks precisely the actual motor speed. A theoretical analysis as well as simulation results to verify the effectiveness of the new method are described in this paper.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays? (2011)

In vivo transplantation is the current 'gold-standard' assay for evaluating mammary stem cell (MaSC) function. Matrigel, a reconstituted extracellular matrix derived from a mouse sarcoma line, is increasingly being utilized for mammary repopulating assays, although original studies were carried out in its absence. This matrix has also been shown to enhance tumor-initiating capacity. Whilst Matrigel increases the rate of engraftment by MaSCs, it also appears to promote progenitor activity that is distinct from bona fide stem cell activity. This caveat should be considered when interpreting mammary reconstitution assays that incorporate Matrigel, particularly when transplanting high cell numbers.
The Ion-Exchange Property of Some Layered Inorganic Materials with Potassium Ion, Rubidium Ion and Cesium Ion, and Selective Cesium Ion-Exchange of Synthetic Mica (2000)

Abstract The ion-exchange property of sodium difluorotetrasilicate, Na-TSM, with potassium, rubidium and cesium ions was investigated in addition to two other typical layered inorganic materials. The selectivity sequence of Na-TSM was Cs+ &gt; Rb+ &gt; K+ and the selectivity difference of Na-TSM was highest among the examined layered materials. It was found from a chemical analysis that cesium ion-exchange participated in magnesium ions, which is a lattice component of Na-TSM, in addition to an ordinary ion-exchange reaction with the interlayer sodium ions. The exchange of cesium ions with magnesium ions was found to be stoichiometric, and was expected to be an ideal ion-exchange reaction. It was a peculiar phenomenon only on Na-TSM. Once cesium ions were exchanged in a Na-TSM lattice, they were hardly released, due to a reverse ion-exchange with sodium ions. The highest selectivity difference and tight binding of cesium ions were interpreted by an ion-exchange with lattice magnesium ion as well as decreased dehydration, which resulted in the interlayer gallery height.
On the mechanisms underlying hypoxia-induced membrane depolarization in striatal neurons (1995)

Clinical and experimental evidence has shown that the striatal neurons are particularly vulnerable to hypoxia and ischaemia. An excessive excitatory action of glutamate, released by the corticostriatal terminals, has been implicated in this peculiar vulnerability of striatal neurons. We have studied the effects of hypoxia on the membrane properties of striatal neurons intracellularly recorded from a corticostriatal slice preparation. Brief (2-10 min) periods of hypoxia produced reversible membrane depolarizations. During the initial phase of the hypoxia-induced depolarization the frequency of action potential discharge was transiently increased; 2-3 min after the onset of hypoxia the firing activity was fully abolished. Brief periods of hypoxia also caused a reversible reduction of the amplitude of the excitatory postsynaptic potentials (EPSPs) evoked by cortical stimulation. Longer period of hypoxia (12-20 min) produced irreversible membrane depolarizations. In voltage-clamp experiments hypoxia caused an inward current coupled with an increased membrane conductance. Tetrodotoxin (TTX) or low calcium (Ca2+)-high magnesium containing solutions blocked synaptic transmission, but they did not reduce the hypoxia-induced electrical changes. Antagonists of excitatory amino acid receptors failed to affect the electrical effects caused by oxygen deprivation. Hypoxia-induced inward currents were reduced either by the potassium (K+) channel blockers, barium and tetraethyl ammonium (TEA) cations, or by lowering external sodium (Na+) concentration. Blockade of ATP-dependent Na(+)-K+ pump by both ouabain and strophanthidin enhanced hypoxia-induced membrane depolarization/inward current. Our findings indicate that the release of excitatory amino acids does not seem to be required for the acute hypoxia-induced electrical changes in striatal neurons. Moreover, TTX-resistant Na+ influx and K+ currents seem to play an important role in the generation of hypoxia-induced electrical changes. These data also suggest that the selective vulnerability of striatal neurons to oxygen deprivation may be caused by their peculiar sensitivity to energy metabolism failure.
Mechanical Distraction for Treatment of Severe Knee Flexion Contractures (1994)

Ten patients (14 knees) with severe knee flexion contractures were treated by gradual mechanical distraction using either the Ilizarov or Orthofix external fixator. Range of motion improved from an average flexion contracture of 60 degrees before surgery to 16 degrees at the follow-up evaluation. Range of motion results were graded good or excellent in five knees, fair in two knees, and poor in three knees. Average total arc of motion remained essentially unchanged when comparing the preoperative (59 degrees) with the follow-up results (63 degrees). However, the functional position of this arc improved significantly. Problems encountered included a "rebound" phenomena after frame removal, with loss of the temporarily increased total arc of motion. The role of hamstring tenotomy and radical posterior knee release remains unclear.
A quantitative study of substituent effects on oxidative cyclization of some 2‐methylsubstituted aldehydes. Thiosemicarbazones induced by ferric chloride (1996)

Abstract In order to gain further mechanistical information about the cyclization of thiosemicarbazones and thiosemicarbazone‐type substrates induced by metallic salts as oxidizing agents, we performed the synthesis of substrates 1a‐s and a kinetic study of the oxidative cyclization of 1 to 5‐imino‐Δ 2 ‐1,3,4‐thiadiazole 2 and 1,2,4‐triazoline‐5‐thione 3 derivatives induced by methanolic ferric chloride solutions. The results of cyclization were compared to those of corresponding semicarbazones. The kinetic data were analyzed by means of the Hammett's equation and ρ values discussed.
Exofacial epitope-tagged glucose transporter chimeras reveal COOH-terminal sequences governing cellular localization. (1993)

The insulin-regulated adipocyte/skeletal muscle glucose transporter (GLUT4) displays a characteristic steady-state intracellular localization under basal conditions, whereas the erythrocyte/brain transporter isoform (GLUT1) distributes mostly to the cell surface. To identify possible structural elements in these transporter proteins that determine their cellular localization, GLUT1/GLUT4 chimera cDNA constructs that contain the hemagglutinin epitope YPYDVPDYA (HA) in their major exofacial loops were engineered. Binding of monoclonal anti-HA antibody to non-permeabilized COS-7 cells expressing HA-tagged transporter chimeras revealed that expression of transporters on the cell surface was strongly influenced by their cytoplasmic COOH-terminal domain. This method also revealed a less marked, but significant effect on cellular localization of amino acid residues between transporter exofacial and middle loops. The subcellular distribution of expressed chimeras was confirmed by immunofluorescence microscopy of permeabilized COS-7 cells. Thus, HA-tagged native GLUT4 was concentrated in the perinuclear region, whereas a chimera containing the COOH-terminal 29 residues of GLUT1 substituted onto GLUT4 distributed to the plasma membrane, as did native GLUT1. Furthermore, a chimera composed of GLUT1 with a GLUT4 COOH-terminal 30-residue substitution exhibited a predominantly intracellular localization. Similar data was obtained in CHO cells stably expressing these chimeras. Taken together, these results define the unique COOH-terminal cytoplasmic sequences of the GLUT1 and GLUT4 glucose transporters as important determinants of cellular localization in COS-7 and CHO cells.
Effect of color on pilot performance and transfer functions using a full-spectrum, calligraphic, color display system (1976)

The use of blue and red color in out-of-window cockpit displays, in full-spectrum calligraphic computer-generated display systems, is studied with attention given to pilot stereographic depth perception and response to visual cues. Displays for vertical approach, with dynamic and frozen-range landing approach and perspective arrays, are analyzed. Pilot transfer function and the transfer function associated with the contrasted approach and perspective arrays are discussed. Out-of-window blue lights are perceived by pilots as indicating greater distance depth, red lights as indicating proximity. The computer-generated chromatic display was adapted to flight simulators for the tests.
Developing Purchasing Strategy: A Case Study of a District Health Authority Using Soft Systems Methodology (1997)

This paper examines the attempt by a District Health Authority (DHA) to create structures (called Purchasing Strategy Groups or PSGs) to facilitate the effective development of its purchasing strategy. The paper is based on a case study design conducted using Soft Systems Methodology (SSM). The research contribution the paper makes is twofold. First, it analyses some of the fundamental management-related difficulties that a DHA can experience when attempting to come to terms with its role and responsibilities in the 1990s. Second, it provides a discussion and evaluation of the utility of SSM for qualitative research in the National Health Service (NHS) in the UK.
C283Y mutation and other C‐terminal nucleotide changes in the γ‐sarcoglycan gene in the Bulgarian Gypsy population (2000)

The authors wish to correct a mistake in the amino acid change stemming from a 490C>T nucleotide change. In this article, the nucleotide change is stated to lead to a Q165X amino acid change. The 490C>T nucleotide change should actually cause a Q164X amino acid change.
Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections (2018)

The increasing number of severe infections with multi-drug-resistant pathogens worldwide highlights the need for alternative treatment options. Given the pivotal role of phagocytes and especially alveolar macrophages in pulmonary immunity, we introduce a new, cell-based treatment strategy to target bacterial airway infections. Here we show that the mass production of therapeutic phagocytes from induced pluripotent stem cells (iPSC) in industry-compatible, stirred-tank bioreactors is feasible. Bioreactor-derived iPSC-macrophages (iPSC-Mac) represent a highly pure population of CD45<sup>+</sup>CD11b<sup>+</sup>CD14<sup>+</sup>CD163<sup>+</sup> cells, and share important phenotypic, functional and transcriptional hallmarks with professional phagocytes, however with a distinct transcriptome signature similar to primitive macrophages. Most importantly, bioreactor-derived iPSC-Mac rescue mice from Pseudomonas aeruginosa-mediated acute infections of the lower respiratory tract within 4-8 h post intra-pulmonary transplantation and reduce bacterial load. Generation of specific immune-cells from iPSC-sources in scalable stirred-tank bioreactors can extend the field of immunotherapy towards bacterial infections, and may allow for further innovative cell-based treatment strategies.
CEREMONIA DE DEVELACION DE LA PLACA DE LA GENERACION 1958 (1984)

DURANTE LA DEVELACION DE LA PLACA DE LA GENERACION DE ESTUDIANTES DE 1958, EL ARQUITECTO ERNESTO VELASCO LEON, DIRECTOR DE LA FACULTAD DE ARQUITECTURA, MANIFESTO QUE LA UNAM SIEMPRE HA SIDO LIDER EN ESTA AREA; PRUEBA DE ELLOS SON LOS TRABAJOS ARQUITECTONICOS REALIZADOS POR UNIVERSITARIOS EN DIVERSAS PARTES DE LA REPUBLICA.