gebhart/patrepeval huggingface dataset:
PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA (1995)

Hormone refractory prostate cancer remains an incurable disease and the discovery of newer agents with higher cytotoxic activity is required. Gossypol is a phenolic compound isolated from cottonseed oil which has been shown to have anti-spermatogenic effects. In in vitro studies, gossypol appears to inhibit the growth of rat prostate cancer cell line MAT-LyLu and human prostate adenocarcinoma cell lines PC-3, LNCaP and DU-145. In vive, gossypol appeared to inhibit tumor growth of subcutaneously implanted MAT-LyLu cells in Copenhagen rats. Gossypol may be an active agent for the treatment of hormone refractory metastatic prostate cancer.
Full-Wave Analysis in SPICE via Model-Order Reduction (2004)

Full-wave analysis is traditionally performed in the frequency domain, or in the time domain using specialized simulators (e.g., finite difference time domain). We describe here an approach that allows us to generate full-wave models for SPICE simulation. The advantage of this approach is that it allows us to easily consider the effects of arbitrary terminations. A frequency-domain finite-element method or method-of-moments solver is used to determine the frequency response of a three-dimensional structure, and then a SPICE model is constructed, which matches this frequency response across a specified frequency band. Some examples are presented to demonstrate the efficacy of the technique.
Metal‐Free Cross‐Dehydrogenative Coupling of Heterocycles with Aldehydes (2013)

A range of heterocyclic compounds were synthesized by a novel, metal-free cross-dehydrogenative coupling between heterocycles and aldehydes under mild reaction conditions that are not sensitive to moisture. The products are formed smoothly and regioselectively at room temperature by a hypervalent iodine mediated transformation. This method has a broad substrate scope and was used in the highly efficient, one-step synthesis of natural products. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Selective Estrogen Receptor Modulation and Reduction in Risk of Breast Cancer, Osteoporosis, and Coronary Heart Disease (2001)

The recognition of selective estrogen receptor modulation in the laboratory has resulted in the development of two selective estrogen receptor modulators (SERMs), tamoxifen and raloxifene, for clinical application in healthy women. SERMs are antiestrogenic in the breast but estrogen-like in the bones and reduce circulating cholesterol levels. SERMs also have different degrees of estrogenicity in the uterus. Tamoxifen is used specifically to reduce the incidence of breast cancer in premenopausal and postmenopausal women at risk for the disease. In contrast, raloxifene is used specifically to reduce the risk of osteoporosis in postmenopausal women at high risk for osteoporosis. The study of tamoxifen and raloxifene (STAR) trial is currently comparing the ability of these SERMs to reduce breast cancer incidence in high-risk postmenopausal women. There is intense interest in understanding the molecular mechanism(s) of action of SERMs at target sites in a woman's body. An understanding of the targeted actions of this novel drug group will potentially result in the introduction of new multifunctional medicines with applications as preventive agents or treatments of breast cancer and endometrial cancer, coronary heart disease, and osteoporosis.
Robotic-Assisted, Body-Weight–Supported Treadmill Training in Individuals Following Motor Incomplete Spinal Cord Injury (2005)

The use of robotic devices may assist physical therapists by providing task-specific practice of stepping in people following neurological injury.
AT <sub>1</sub> Receptor Agonistic Antibodies From Preeclamptic Patients Cause Vascular Cells to Express Tissue Factor (2000)

We conclude that AT(1)-AA and Ang II both stimulate the AT(1) receptor and initiate a signaling cascade resulting in TF expression. These results show an action of AT(1)-AA on human cells that could contribute to the pathogenesis of preeclampsia.
Bag of Freebies for Training Object Detection Neural Networks (2019)

Training heuristics greatly improve various image classification model accuracies~\cite{he2018bag}. Object detection models, however, have more complex neural network structures and optimization targets. The training strategies and pipelines dramatically vary among different models. In this works, we explore training tweaks that apply to various models including Faster R-CNN and YOLOv3. These tweaks do not change the model architectures, therefore, the inference costs remain the same. Our empirical results demonstrate that, however, these freebies can improve up to 5% absolute precision compared to state-of-the-art baselines.
Improved Grasp Force Sensitivity for Prosthetic Hands Through Force-Derivative Feedback (2008)

Sensitivity of applied grasp force is improved for a myoelectrically controlled prosthetic hand under force control through normal force-derivative feedback. Benchtop experiments and results from 12 human test subjects indicate that normal force-derivative feedback can be used in prosthetic hands to help prevent accidental damage to delicate objects.
Modeling cloud resources using machine learning (2013)

Cloud computing is a new Internet infrastructure paradigm where management optimization has become a challenge to be solved, as all current management systems are human-driven or ad-hoc automatic systems that must be tuned manually by experts. Management of cloud resources require accurate information about all the elements involved (host machines, resources, offered services, and clients), and some of this information can only be obtained a posteriori. Here we present the cloud and part of its architecture as a new scenario where data mining and machine learning can be applied to discover information and improve its management thanks to modeling and prediction. As a novel case of study we show in this work the modeling of basic cloud resources using machine learning, predicting resource requirements from context information like amount of load and clients, and also predicting the quality of service from resource planning, in order to feed cloud schedulers. Further, this work is an important part of our ongoing research program, where accurate models and predictors are essential to optimize cloud management autonomic systems.
Network-Coded SD-WAN in Multi-Access Systems for Delay Control (2019)

An industrial IoT network may involve hundreds of IoT end-devices deployed over large geographical wide areas networks (WAN). These devices are expected to operate over several years and their individual communication interface may be gradually upgraded with multiple communication links in order to fit the changing application and data rate requirement. As industrial networks are expected to perform with high reliability and availability, a continuous monitoring and maintenance of these communication links is essential. A software defined WAN (SD-WAN) based solution allows to adaptively monitor and manage the connectivity links as per the application requirement. In this paper we design and implement a working SD-WAN based multi-access system for upstream communication between an IoT device and the control center. Each IoT device may have multiple cellular interfaces, and we control the end-to-end delay jitter variation across the different interfaces via an intelligent traffic splitting scheme.We provide an analysis of end-to-end delay jitter under LTEs uplink connection and use the structural results so obtained to design a traffic split mechanism. We validate our analysis, and provide traffic split performance results from our working multi-access system.
Development and Effects Analysis of The Decentralized Rainwater Management System by Field Application (2014)

In this study, we developed a modular rainwater infiltration system that can be applied for general purposes in urban areas to prepare for localized heavy rain caused by climatic change. This study also analyzed the system's effects on reducing runoff. An analysis of the system's effects on reducing runoff based on rainfall data and monitoring data obtained between September 2012 and December 2013 after the system was installed showed that approximately 20~22% of the runoff overflowed from the infiltration facility. Also, an analysis of the runoff that occurred during the monsoon season showed that 25% of the runoff overflowed through the storm sewer system of the urban area. These results show that the rainwater overflows after infiltrating the detention facility installed in the area during high-intensity rainfall of 100mm or higher or when precipitation is 100mm for 3~4 days without the prior rainfall. According to precipitation forecasts, torrential rainfall is becoming increasingly prevalent in Korea which is increasing the risk of floods. Therefore, the standards for storm sewer systems should be raised when planning and redeveloping urban areas, and not only should centralized facilities including sewer systems and rainwater pump facilities be increased, but a comprehensive plan should also be established for the water cycle of urban areas. This study indicates that decentralized rainwater management can be effective in an urban area and also indicates that the extended application of rainwater infiltration systems can offer eco-friendly urban development.
A new technique to improve voltage controlled nodes (PV nodes) in the current injection Newton-Raphson power-flow analysis (2010)

Newton Raphson load flow based on current injection mismatches (CIM) is very efficient when all the buses are PQ buses. However, when PV buses exist, the performance of the method is affected due to the representation of additional equations for every PV node. Hence, the CIM is not reliable for solving transmission systems and found wide usage in distribution systems. The present paper describes a new representation for PV nodes by using a hybrid power flow formulation using current and power mismatches. The current and power equations are written in rectangular coordinates. The Jacobian matrix (2n×2n) has the same structure as the nodal admittance matrix. The PQ buses equation is developed based on current mismatches whereas PV buses equations are based on power mismatches. In this method, only one equation is required each PV bus. The initial results show that the algorithm offers good performance when it is compared with both the CIM method and the standard NR method.
Gary Tomlinson. Music in Renaissance Magic: Toward a Historiography of Others. Chicago and London: University of Chicago Press, 1993. xvi, 291 pp. ISBN 0-226-80791-6 (hardcover) (1995)

Gary Tomlinson. Music in Renaissance Magic: Toward a Historiography of Others. Chicago and London: University of Chicago Press, 1993. xvi, 291 pp. ISBN 0-226-80791-6 (hardcover). Un article de la revue Canadian University Music Review / Revue de musique des universités canadiennes (Numéro 15, 1995, p. 1-206) diffusée par la plateforme Érudit.
Serotonergic modulating drugs for functional gastrointestinal diseases (2002)

After many years of basic research we have now begun to learn how to manipulate the serotonergic mechanisms within the gut. This has lead to a number of significant advances including 5HT3 antagonists for the treatment of functional diarrhoea, 5HT4 agonists for the treatment of constipation and 5HT1 agonists for the treatment of impaired fundal relaxation. Initial enthusiasm has been somewhat dented by the withdrawal of alosetron because of ischaemic colitis, but it remains to be seen whether this adverse event will be seen with other 5HT3 antagonists. Finally it should be recognized that, in a substantial proportion of patients attending clinics complaining of functional symptoms, anxiety is a major component. The drugs so far described are by and large devoid of CNS effects. It remains possible therefore that a drug which combines both peripheral and central effects would likely to be beneficial.
Corea del Sur, ¿el nuevo Japón? (2012)

Aldosterone and excessive salt intake are obviously implicated in human arteriosclerosis. Aldosterone activates NADPH oxidase that induces superoxide production and cardiovascular cell hypertrophy. The activity of NADPH oxidase is influenced by the expression of its subunit, through which, vasoactive agents activate in the enzyme. Here, we show that aldosterone elicited overexpression of the NOX1 catalytic subunit of NADPH oxidase in the presence of high salt in A7r5 vascular smooth muscle cells. We also showed that NOX1 is a key subunit involved in physiological aldosterone-induced NADPH oxidase activation. Aldosterone dose-dependently increased NOX1 expression and NADPH activity, which subsequently caused superoxide over-production and A7r5 cell hypertrophy. However, aldosterone had little effect on any of NOX1, superoxide over-production and cell hypertrophy in NOX1 knock-down A7r5 cells. These results suggest that the aldosterone-induced effects are mainly generated through NOX1. Aldosterone-induced NOX1 over-expression was augmented by 145 mM sodium chloride, as compared with control medium containing 135 mM NaCl. However, NOX1 over-expression was not induced in the absence of aldosterone, even in the presence of 185 mM NaCl. The mineralocorticoid receptor antagonist, eplerenone, completely abolished NOX1 over-expression, indicating that aldosterone is essential for this process.
Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease (2016)

The human herpesviruses are ubiquitous viruses and have a prevalence of over 90% in the adult population. Following a primary infection they establish latency and can be reactivated over a person's lifetime. While it is well accepted that human herpesviruses are implicated in numerous diseases ranging from dermatological and autoimmune disease to cancer, the role of lytic proteins in the pathophysiology of herpesvirus-associated diseases remains largely understudies. Only recently have we begun to appreciate the importance of lytic proteins produced during reactivation of the virus, in particular the deoxyuridine triphosphate nucleotidohydrolases (dUTPase), as key modulators of the host innate and adaptive immune responses. In this review, we provide evidence from animal and human studies of the Epstein-Barr virus as a prototype, supporting the notion that herpesviruses dUTPases are a family of proteins with unique immunoregulatory functions that can alter the inflammatory microenvironment and thus exacerbate the immune pathology of herpesvirus-related diseases including myalgic encephalomyelitis/chronic fatigue syndrome, autoimmune diseases, and cancer.
TONDU (TDU), a novel human protein related to the product of <i>vestigial</i> (<i>vg</i>) gene of <i>Drosophila melanogaster</i> interacts with vertebrate TEF factors and substitutes for Vg function in wing formation (1999)

The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. In Drosophila, Scalloped (Sd) interacts with Vestigial (Vg) to form a complex, which binds DNA through the Sd TEA/ATTS domain. The Sd-Vg heterodimer is a key regulator of wing development, which directly controls several target genes and is able to induce wing outgrowth when ectopically expressed. Here we show that Vg contains two distinct transcriptional activation domains, suggesting that the function of Vg is to mediate transcriptional activation by Sd. By expressing a chimeric GAL4-Sd protein in Drosophila, we found that the transcriptional activity of the Vg-Sd heterodimer is negatively regulated at the AP and DV boundary of the wing disc. We also identify a novel human protein, TONDU, which contains a short domain homologous to the domain of Vg required for interaction with Sd. We show that TONDU specifically interacts with a domain conserved in all the mammalian TEF factors. Expression of TDU in Drosophila by means of the UAS-GAL4 system shows that this human protein can substitute for Vg in wing formation. We propose that TDU is a specific coactivator for the mammalian TEFs.
Cereal Genomics (2013)

In Cereal Genomics: Methods and Protocols, expert researchers provides modern protocols for the analysis and manipulation of cereal genomes. Techniques for isolation and analysis of DNA and RNA from b
Dynamic Mode Decomposition Based Video Shot Detection (2018)

Shot detection is widely used in video semantic analysis, video scene segmentation, and video retrieval. However, this is still a challenging task, due to the weak boundary and a sudden change in brightness or foreground objects. In this paper, we propose a new framework based on dynamic mode decomposition (DMD) for shot boundary detection. Because the DMD can extract several temporal foreground modes and one temporal background mode from video data, shot boundaries can be detected when the amplitude changes sharply. Here, the amplitude is the DMD coefficient to restore the video. The main idea behind the shot boundaries detection is finding the amplitude change of background mode. We can reduce error detection when the illumination changes sharply or the foreground object (or camera) moves very quickly. At the same time, our algorithm has a high detection accuracy, even the color changes are not obvious, the illumination changes slowly, or the foreground objects overlap. Meanwhile, a color space for DMD is selected for reducing false detection. Finally, the effectiveness of our method will be demonstrated through detecting the shot boundaries of the various content types of videos.
High-Precision Gas Chromatography (1971)

A high-precision chromatograph has been used for determination of differential thermodynamic quantities of two gas-liquid systems. Individual α values and consequently Δ(ΔH°) were determined with a precision of ±0.02%. The precision in the measurement of Δ(ΔG°) was ±0.2%. These values represent an order of magnitude improvement over the best previously reported data. Heats of adsorption of hydrocarbons on carbon black and silica gel were also determined with a precision of ±0.6%.
<i>Limacina helicina</i>shell dissolution as an indicator of declining habitat suitability owing to ocean acidification in the California Current Ecosystem (2014)

Few studies to date have demonstrated widespread biological impacts of ocean acidification (OA) under conditions currently found in the natural environment. From a combined survey of physical and chemical water properties and biological sampling along the Washington-Oregon-California coast in August 2011, we show that large portions of the shelf waters are corrosive to pteropods in the natural environment. We show a strong positive correlation between the proportion of pteropod individuals with severe shell dissolution damage and the percentage of undersaturated water in the top 100 m with respect to aragonite. We found 53% of onshore individuals and 24% of offshore individuals on average to have severe dissolution damage. Relative to pre-industrial CO2 concentrations, the extent of undersaturated waters in the top 100 m of the water column has increased over sixfold along the California Current Ecosystem (CCE). We estimate that the incidence of severe pteropod shell dissolution owing to anthropogenic OA has doubled in near shore habitats since pre-industrial conditions across this region and is on track to triple by 2050. These results demonstrate that habitat suitability for pteropods in the coastal CCE is declining. The observed impacts represent a baseline for future observations towards understanding broader scale OA effects.
ksniffer: determining the remote client perceived response time from live packet streams (2004)

As dependence on the World Wide Web continues to grow, so does the need for businesses to have quantitative measures of the client perceived response times of their Web services. We present ksniffer, a kernel-based traffic monitor capable of determining pageview response times as perceived by remote clients, in real-time at gigabit traffic rates. ksniffer is based on novel, online mechanisms that take a “look once, then drop ” approach to packet analysis to reconstruct TCP connections and learn client pageview activity. These mechanisms are designed to operate accurately with live network traffic even in the presence of packet loss and delay, and can be efficiently implemented in kernel space. This enables ksniffer to perform analysis that exceeds the functionality of current traffic analyzers while doing so at high bandwidth rates. ksniffer requires only to passively monitor network traffic and can be integrated with systems that perform server management to achieve specified response time goals. Our experimental results demonstrate that ksniffer can run on an inexpensive, commodity, Linux-based PC and provide online pageview response time measurements, across a wide range of operating conditions, that are within five percent of the response times measured at the client by detailed instrumentation. 1
Macrophages: Current Views on Their Differentiation, Structure, and Function (1989)

Macrophages are large mononuclear phagocytes that represent the major differentiated elements of the mononuclear phagocytic system. They arise from distinct progenitors in the bone marrow, and their immediate precursors, the monocytes, emigrate from the vascular compartment into many tissues and organs where they develop into mature macrophages. The latter display diverse morphological and functional characteristics, depending on the environmental stimuli that they receive. This phenotypic heterogeneity is, therefore, the final consequence of a series of down-regulation of some cellular processes and the up-regulation of others. The kinetics of the production of macrophages and their participation in various physiological and pathological phenomena is the subject of this review.
Op Amps for Everyone Ed. 5 (2017)

Op Amps for Everyone, Fifth Edition, will help you design circuits that are reliable, have low power consumption, and can be implemented in as small a size as possible at the lowest possible cost. It bridges the gap between the theoretical and practical by giving pragmatic solutions using components that are available in the real world from distributors. The book does not just give a design with a transfer function; instead, it provides design tools based on transfer function, getting you to a working circuit so you can make the right decision on which op amp is best for the job at hand. With this book you will learn: single op amp designs that get the most out of every amplifier; which specifications are of most importance to your design, enabling you to narrow down the list of amplifiers to those few that are most suitable; strategies for making simple tweaks to the design?changes that are often apparent once a prototype has been constructed; how to design for hostile environments?extreme temperatures, high levels of shock, vibration, and radiation?by knowing which circuit parameters are likely to degrade and how to counteract that degradation.Features real world op amp selection guidesTeaches which op amp is best for the jobIncludes design circuits with real world component valuesContains guidelines for developing the entire signal chain, from specification for the transducer to power supply and data converterIncludes new coverage of negative regulation techniques and op amp stability, negative regulation techniques, extended electronics theory and troubleshooting