gebhart/patrepeval huggingface dataset:
Melanomas that develop within the eye inhibit lymphocyte proliferation (1997)

Experiments were performed to compare the ability of ocular and skin melanoma cells to stimulate T cells. Primary melanoma cell lines were obtained from a series of patients with either eye or skin melanoma. The ability of tumor cells to stimulate T cells in the absence of exogenous growth factors was assessed in mixed-lymphocyte tumor cell cultures in which allogeneic lymphocytes were stimulated with irradiated ocular or skin melanoma cells. Expression of HLA class I and class II on tumor cells, in the presence or absence of IFN-gamma, was determined by flow cytometry. The ability of tumor cells to inhibit T-cell proliferation was determined by adding various concentrations of irradiated tumor cells to standard mixed-lymphocyte cultures. Our results indicate that primary skin melanoma cells induce vigorous proliferation of allo-antigen-specific T cells. By contrast, ocular melanoma cells failed to induce significant T-cell proliferation. The failure of ocular melanoma cells to stimulate lymphocyte proliferation was not due to low levels of either class I or class II on tumor cells since tumor cells treated with IFN-gamma expressed high levels of class I and class II but still failed to induce lymphocyte proliferation. Ocular melanoma cells inhibited lymphocyte proliferation, as shown by experiments in which a small number of tumor cells prevented proliferation of T cells in mixed-lymphocyte cultures. Inhibition of lymphocyte proliferation required cell-to-cell contact, and supernatants from tumor cell cultures did not prevent lymphocyte proliferation. Moreover, the ability of ocular melanoma cells to inhibit T-cell proliferation was lost when tumor cells migrated from the eye and formed hepatic metastases. We conclude that there is a fundamental difference in the immunogenicity of ocular and skin melanoma cells. Ocular melanomas, but not primary skin melanomas, are poorly immunogenic tumors that inhibit T-cell proliferation. Our results imply that the immunogenicity of melanoma cells is altered when they develop within the unique ocular micro-environment.
Damage localization and quantification of earthquake excited RC-frames (1998)

In the paper a recently proposed method for damage localization and quantification of RC-structures from response measurements is tested on experimental data. The method investigated requires at least one response measurement along the structures and the ground surface acceleration. Further, the two lowest time-varying eigenfrequencies of the structure must be identified. The data considered are sampled from a series of three RC-frame model tests performed at the structural laboratory at Aalborg University, Denmark during the autumn of 1996. The frames in the test series were exposed to two or three series of ground motions of increasing magnitude. After each of these runs the damage state of the frame was examined and each storey of the frame were classified into one of the following six classifications: undamaged, cracked, lightly damaged, damaged, severely damaged or collapse. During each of the ground motion events the storey accelerations were measured by accelerometers. After application of the last earthquake sequence to the structure the frames were cut into pieces and each of the beams and columns was statically tested and damage assessment was performed using the obtained stiffnesses. The damage in the storeys determined by the suggested method was then compared to the damage classification from the visual inspection as well as the static tests. It was found that especially in the cases where the damage is concentrated in a certain area of the structure a very good damage assessment is obtained using the suggested method. © 1998 John Wiley & Sons, Ltd.
Determining Interpretation Parameters Using 2D Magnetic Resonance Measurements (2014)

Summary Reservoir characterization involves the determination of a large number of parameters. This process includes determination of parameters needed for accurate estimation of reservoir properties such as water saturation, permeability, etc. The large number of parameters and their variability makes characterization of clastic reservoirs difficult; carbonate reservoirs are often considered even more challenging because of the increased variability of rock types. Modern petrophysical measurements provide means to estimate many of these parameters that were hitherto assumed. We focus on the use of wireline dielectric measurements and core magnetic resonance (MR) measurements to provide tortuosity (e.g., the cementation exponent m) and wettability estimates of a subject well. A comparison between dielectric-derived tortuosity and MRderived tortuosity shows good agreement. Once tortuosity is determined, a wettability index can be estimated from the MR diffusion measurement. Modern logging measurements, such as dielectric and magnetic resonance, can be used to solve for parameters that heretofore had either to be assumed (e.g., cementation exponent) or ignored (formation wettability).
경피적 관상동맥 중재술을 받은 환자를 대상으로 심장호흡물리치료에 대한 효과 - 체계적 고찰과 메타분석 (2019)

PURPOSE: This study examined the effects of cardiopulmonary physiotherapy on the cardiopulmonary function, metabolism, inflammatory markers, and quality of life in patients with coronary artery disease who underwent percutaneous coronary intervention (PCI).
METHODS: Electronic bibliographic databases of a regional information sharing system (RISS) and PubMed were searched to identify studies with randomized and non-randomized controlled trials. As the final outcome, 320 publications were identified and 18 studies met the inclusion and exclusion criteria. All studies were assessed for the quality of study using Cochrane’s risk of bias.
RESULTS: Sixteen studies met the inclusion criteria, in which meta-analysis had been conducted to examine the effectiveness of cardiopulmonary physiotherapy on the cardiopulmonary function, metabolism, inflammatory markers, and quality of life in patients undergoing PCI. Meta-analysis based on a random effect model showed that the cardiopulmonary physiotherapy was beneficial in improving the cardiopulmonary function, metabolism, inflammatory markers, and quality of life. In particular, there was a significant effect on the peak oxygen uptake (effect size 5.30%; 95% confidence interval 3.62~6.97). Cardiopulmonary physiotherapy for a during period of 6 weeks or more was effective in significantly improving the cardiopulmonary function and metabolism function in a subgroup analysis, but cardiopulmonary physiotherapy for less than 6 weeks was not effective.
CONCLUSION: Cardiopulmonary physiotherapy has positive effects on the cardiopulmonary function, metabolism, inflammatory markers, and quality of life in patients undergoing PCI.
A new interlayer interconnect technology for multilayer fabrication (2002)

A novel approach to multilayered circuitry based on flexible substrates has been established by prototype manufacture of test vehicles. The multilayered circuitry is comprised of new conductive bondply and layer pairs (ViaThin/sup TM/) based on 50 /spl mu/m (2 mil) polyimide film. The bondply base film is patterned with 100 /spl mu/m (4 mil) vias and filled with an organic-metallic composite material (Ormeto/sup R/) used to interconnect the layer pairs. Circuit traces of 50 /spl mu/m (2 mil) width, multilayered capture pads of 225 /spl mu/m (9 mil) diameter, and integrally formed conductive vias of 25 /spl mu/m (1 mil) diameter comprise the layer pairs in the work described here. The bondply vertically interconnects the layer pairs using a lamination process common in the printed circuit board industry. Eight-layer circuits have been fabricated, employing four circuit layer pairs and three bondply interlayers. The multilayer technology presented was developed within the DARPA-funded MCM-L consortium.
Design and implementation of a push-pull phase-shifted bi-directional inverter with a dsPIC controller (2009)

This paper presents design and implementation of a bi-directional inverter, including a high frequency transformer, a push-pull switch configuration at the dc side, a cycloconverter at the ac side, and a dsPIC controller. The dc/ac conversion is achieved with a phase-shifted control strategy. In addition, this topology also can achieve an ac/dc conversion with the PFC function. In this circuit, the dsPIC realizes almost all functions, including generation of PWM signals, A/D conversion, phase shift, circuit protection, and PFC during ac/dc conversion. The proposed bi-directional inverter can reduce weight, size and volume significantly as compared to a conventional low frequency transformer approach. Experimental results obtained from a prototype with a dc side voltage of 48 V, an ac side voltage of 110 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> , and power rating of 500 W have verified its feasibility.
On The Physiology and Pharmacology of the Earthworm Gut (1939)

ABSTRACT The physiology of the gut movements in invertebrates has been little studied. In the case of the earthworm, although numerous investigations have been published on the physiology of locomotion and of the neuro-muscular structures of the body wall, nothing has yet appeared on the gut movements. It was with the intention of throwing light on this problem that the present investigation was undertaken.
Xanthogranulomatous Pyelonephritis in a Renal Allograft: A Case Report (1989)

We report a case of xanthogranulomatous pyelonephritis in a renal allograft. The kidney was not removed and there was an initial response to antibiotic therapy, with amelioration of toxicity and improvement in renal function. However, the kidney failed 10 months later in association with histological changes of chronic rejection.
Linking genes to diseases: it's all in the data (2009)

Genome-wide association analyses on large patient cohorts are generating large sets of candidate disease genes. This is coupled with the availability of ever-increasing genomic databases and a rapidly expanding repository of biomedical literature. Computational approaches to disease-gene association attempt to harness these data sources to identify the most likely disease gene candidates for further empirical analysis by translational researchers, resulting in efficient identification of genes of diagnostic, prognostic and therapeutic value. Existing computational methods analyze gene structure and sequence, functional annotation of candidate genes, characteristics of known disease genes, gene regulatory networks, protein-protein interactions, data from animal models and disease phenotype. To date, a few studies have successfully applied computational analysis of clinical phenotype data for specific diseases and shown genetic associations. In the near future, computational strategies will be facilitated by improved integration of clinical and computational research, and by increased availability of clinical phenotype data in a format accessible to computational approaches.
<i>WWOX</i> : A candidate tumor suppressor gene involved in multiple tumor types (2001)

We previously reported the construction of a P1-derived artificial chromosome (PAC) contig encompassing a set of homozygous deletions of chromosome 16q23-24.1 found in primary ovarian tumor material and several tumor cell lines. Using these PAC clones in a cDNA selection experiment, we have isolated a Sau3A fragment homologous to the WWOX transcript (GenBank accession no. ) from normal human ovarian surface epithelial (HOSE) cells. We demonstrate the homozygous deletion of WWOX exons from ovarian cancer cells and three different tumor cell lines. We also identify an internally deleted WWOX transcript from a further primary ovarian tumor. In three of these samples the deletions result in frameshifts, and in each case the resulting WWOX transcripts lack part, or all, of the short chain dehydrogenase domain and the putative mitochondrial localization signal. Sequencing revealed several missense polymorphisms in tumor cell lines and identified a high level of single nucleotide polymorphism (SNP) within the WWOX gene. This evidence strengthens the case for WWOX as a tumor suppressor gene in ovarian cancer and other tumor types.
Adhesives and Adhesive Tapes (2001)

Adhesion theories raw materials for adhesives classification for adhesives individual adhesive systems (adhesives that set without a chemical reaction adhesives setting by chemical reaction) bonding techniques testing of adhesives applications of adhesives (bookbinding gluing of wood and wooden materials footwear adhesives bonding of plastics bonding of elastomers bonding of metals adhesives for wallcoverings floorcovering adhesives building construction adhesives adhesives for bonding textile fabrics flocking adhesives adhesives for bonding glass, in automobile manufacture, in aircraft construction and sealants in electronics medical adhesives household adhesives applications of anaerobic adhesives) economic aspects.
Number plate reading using computer vision (2002)

The main tasks of a number plate recognition system are the location of the number plate area in the image, the segmentation of the characters and their identification. These tasks are strongly inter-related, mainly because the way to check if the number plate has been correctly located is based on the result of the character identification process (it should correspond to a predefined syntax). Algorithmic improvements to previous versions of the system, based on the results of intensive testing, are described in this paper. For the location of the number plate area in the image, a new line-based method has been developed. The method, instead of looking for character like shapes in the image, takes advantage of the "signature" of the number plate area in a horizontal cross-section of the image. The method used for the segmentation of the characters is derived from a technique first proposed by Lu (1995). The identification of the characters uses the OCR engine developed by Barroso et al. (1995), based on the critical points method.
Feminine Sensibility in The Namesake: A Study (2015)

This paper deals with the theme of dislocation, displacement, divided identity, problems of history, confrontation with racism, the problematic inbetweenness and sometimes “comforting” hybridity abound in diasporic fiction The Namesake . Much research and writings in the area of post-colonial feminism have focussed on women’s problems and search for identity in a “foreign” land. But then one needs to study these works to explore the subtle semantic inflections and the politics of gender in the representation of men belonging to the Indian diaspora and configure masculinity from postcolonial perspective.
Ontogeny of hyaluronan secretion during early mouse development (1993)

The ontogeny of hyaluronan (HA) secretion during early mouse embryogenesis has been investigated using a biotin-labelled HA-binding complex from cartilage proteoglycan. HA is first secreted by visceral endoderm cells of the early egg cylinder on day 5.5 post coitum (p.c.), predominantly into the expanding yolk cavity. On day 6.5 p.c., HA is present in both the yolk and proamniotic cavities, but pericellular staining is restricted to the visceral endoderm and a population of embryonic ectoderm cells at the antimesometrial end of the proamniotic cavity. By the primitive streak stage, HA is secreted into the ectoplacental, exocoelomic, amniotic and yolk cavities, whilst the only cells exhibiting pericellular staining are those of the embryonic and extraembryonic mesoderm, including the allantois. Comparisons of HA-staining patterns of cultured whole blastocysts, microdissected trophectoderm fragments and immunosurgically isolated inner cell masses, revealed no trophoblast-associated HA secretion during outgrowth in vitro but significant synthetic activity by the endodermal derivatives of differentiating inner cell masses. To identify the cell lineages responsible for secretion of HA into the embryonic cavities and to investigate the origin of the HA observed around migrating mesoderm cells, day 7.5 p.c. primitive streak stage conceptuses were dissected into their various embryonic and extraembryonic cell lineages. HA secretion was observed after short-term suspension culture of mesoderm, embryonic ectoderm and embryonic endoderm, but was undetectable in fragments of ectoplacental cone, parietal yolk sac (primary giant trophoblast and parietal endoderm), extraembryonic ectoderm or extraembryonic endoderm. The level of synthesis by the HA-positive tissues was markedly enhanced by culture in medium containing serum, compared with that obtained following culture in medium supplemented with a defined serum substitute containing insulin, transferrin, selenous acid and linoleic acid. This suggests that additional growth factors, present in serum but absent from the serum substitute, are required for optimal HA synthesis by the HA-secreting tissues in vitro, and probably also in vivo. The implications of these events for implantation and the development of peri- and early post-implantation mouse embryos are discussed, and a new role for HA in the initial formation and expansion of the embryonic cavities is proposed.
Knoop Hardness Anisotropy and Plastic Deformation in Mn‐Zn Ferrite Single Crystals (1971)

The Knoop hardness anisotropy and plastic deformation markings around the DPH indentation were investigated for an Mn‐Zn ferrite single crystal. Knoop hardness values, which depended primarily on the crystallographic direction, were represented on a standard stereographic triangle. The hardness was maximum in the <001> direction and minimum in the <111> and <011> directions. The patterns of the plastic deformation markings show that the ferrite deforms plastically at room temperature by {110} <110> and {111} <110> slip.
DIET AND HISTOLOGIC TYPES OF BENIGN BREAST DISEASE DEFINED BY SUBSEQUENT RISK OF BREAST CANCER (1990)

The authors investigated the relation between diet and histologic types of benign breast disease defined by subsequent risk of breast cancer in a case-control study of volunteers who entered the Vancouver Center of the Canadian National Breast Screening Study between 1983 and 1985. Proliferative benign breast disease (n = 124) was inversely associated with vitamin A supplementation (vitamin A user vs. nonuser, odds ratio (OR) = 0.5) and frequent green vegetable consumption (frequent vs. rare consumption, OR = 0.3), whereas severe atypias and borderline carcinoma in situ (n = 32) were directly associated with frequent meat fats consumption (frequent vs. rare consumption, OR = 3.2) with no association with vitamin A or vegetable consumption. No dietary relations were found for histologic types of benign breast disease at no increased risk for subsequent breast cancer (n = 274). The implications of these findings in relation to the etiology of breast cancer are discussed.
Template Synthesis and Self-Assembly of Nanoscopic Polymer “Pencils” (2003)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTTemplate Synthesis and Self-Assembly of Nanoscopic Polymer "Pencils"Sung In Moon and Thomas J. McCarthyView Author Information Polymer Science and Engineering Department, University of Massachusetts, Amherst, Massachusetts 01003 Cite this: Macromolecules 2003, 36, 12, 4253–4255Publication Date (Web):May 14, 2003Publication History Received13 January 2003Revised16 April 2003Published online14 May 2003Published inissue 1 June 2003https://pubs.acs.org/doi/10.1021/ma0300239https://doi.org/10.1021/ma0300239rapid-communicationACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views815Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Chemical structure,Hydrocarbons,Membranes,Self organization Get e-Alerts
The Social Studies Debate Goes On (1991)

Social studies in the K- 12 school curriculum entered the decade of the 1990s under heavy attack from many critics. National studies focusing on subjects such as civics, history, and geography implied the need for major reforms in the total social studies program.
Transistor permutation for better transistor chaining (2009)

Custom layout design style remains to be an effective way of improving and differentiating the performance of integrated circuits. In this paper, we revisit the classic problem of transistor chaining, a key step in transistor level layout generation and report a systematic method for permutating transistors in a circuit topology such that without altering its logic function, the chance of finding transistor chains with minimum number of diffusion breaks is increased. The results on nontrivial circuits show that our algorithm can consistently outperform the best reported results in the literature.
Application of the phase partition method to a hydrophobic membrane protein, phospholipase Al from Escherichia coli (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplication of the phase partition method to a hydrophobic membrane protein, phospholipase Al from Escherichia coliPer A. AlbertssonCite this: Biochemistry 1973, 12, 13, 2525–2530Publication Date (Print):June 1, 1973Publication History Published online1 May 2002Published inissue 1 June 1973https://pubs.acs.org/doi/10.1021/bi00737a024https://doi.org/10.1021/bi00737a024research-articleACS PublicationsRequest reuse permissionsArticle Views200Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts