gebhart/patrepeval huggingface dataset:
Recurrence of <i>OTT–MAL</i> fusion in t(1;22) of infant AML‐M7 (2001)

Translocation t(1;22)(p13;q13) is associated with a peculiar subtype of acute megakaryocytic leukemia (M7) occurring in infants. We have recently characterized a fusion gene, OTT-MAL, resulting from this translocation. We now report three additional cases and show that this gene fusion is present in all five t(1;22) cases studied to date. Nucleotide sequence analysis of two translocation breakpoints suggests a nonhomologous end joining mechanism in the genesis of this translocation and reveals a noncanonical topoisomerase II-like consensus sequence within the OTT gene. FISH and PCR techniques described in this work are useful for identifying t(1;22) associated with M7.
Catalysis of a protein folding reaction: Mechanistic implications of the 2.0 .ANG. structure of the subtilisin-prodomain complex (1995)

Biosynthesis of subtilisin is dependent on a 77 amino acid, N-terminal prodomain, which is autocatalytically processed to create the mature form of the enzyme [Ikemura, H., Takagi, H., & Inouye, M. (1987) J. Biol. Chem. 262, 7859-7864]. In order to better understand the role of the prodomain in subtilisin folding, we have determined the structure of the processed complex between the prodomain and subtilisin Sbt-70, a mutant engineered for facilitated folding. The prodomain is largely unstructured by itself but folds into a compact structure with a four-stranded antiparallel beta-sheet and two three-turn alpha-helices when complexed with subtilisin. The Ka of the complex is 2 x 10(8) M-1 at 25 degrees C. The prodomain binds on subtilisin's two parallel surface alpha-helices and supplies caps to the N-termini of the two helices. The C-terminal strand of the prodomain binds in the subtilisin substrate binding cleft. While Sbt-70 is capable of independent folding, the prodomain accelerates the process by a factor of > 10(7) M-1 of prodomain in 30 mM Tris-HCl, pH 7.5, at 25 degrees C. X-ray structures of the mutant subtilisin folded in vitro either with or without the prodomain are compared and show that the identical folded state is achieved in either case. A model of the folding reaction of Sbt-70 and the prodomain is described as the following equilibria: P + Su<-->Pf--SI<-->Pf--Sf, where Su and P are Sbt-70 and prodomain, respectively, which are largely unstructured at the start of the reaction, Pf--SI is a collision complex of a partially folded Sbt-70 and folded prodomain, and Pf--Sf is the complex of folded Sbt-70 and prodomain.(ABSTRACT TRUNCATED AT 250 WORDS)
A Novel Protein Geranylgeranyltransferase-I Inhibitor with High Potency, Selectivity, and Cellular Activity (2006)

Inhibiting protein prenylation is an attractive means to modulate cellular processes controlled by a variety of signaling proteins, including oncogenic proteins such as Ras and Rho GTPases. The largest class of prenylated proteins contain a so-called CaaX motif at their carboxyl termini and are subject to a maturation process initiated by the attachment of an isoprenoid lipid by either protein farnesyltransferase (FTase) or protein geranylgeranyltransferase type I (GGTase-I). Inhibitors of FTase, termed FTIs, have been the subject of intensive development in the past decade and have shown efficacy in clinical trials. Although GGTase-I inhibitors (GGTIs) have received less attention, accumulating evidence suggests GGTIs may augment therapies using FTIs and could be useful to treat a myriad of additional disease states. Here we describe the characterization of a selective, highly potent, and cell-active GGTase-I inhibitor, GGTI-DU40. Kinetic analysis revealed that inhibition by GGTI-DU40 is competitive with the protein substrate and uncompetitive with the isoprenoid substrate; the Ki for the inhibition is 0.8 nM. GGTI-DU40 is highly selective for GGTase-I both in vitro and in living cells. Studies indicate GGTI-DU40 blocks prenylation of a number of geranylgeranylated CaaX proteins. Treatment of MDA-MB-231 breast cancer cells with GGTI-DU40 inhibited thrombin-induced cell rounding via a process that involves inhibition of Rho proteins without significantly effecting parallel mobilization of calcium via Gbetagamma. These studies establish GGTI-DU40 as a prime tool for interrogating biologies associated with protein geranylgeranylation and define a novel structure for this emerging class of experimental therapeutics.
STOCHASTIC ANALYSIS ON PROJECT DURATION UNDER THE REQUIREMENT OF CONTINUOUS RESOURCE UTILIZATION (2002)

In repetitive construction projects (e.g., multistory buildings, pipelines, and highways), resources (labor and equipment) perform work and move from one repetitive unit to the next. The Repetitive Scheduling Method (RSM) has been proposed to ensure the continuous utilization of resources from unit to unit, which meets the goal of eliminating waste (i.e., unproductive idleness between units) in Lean Construction. This paper demonstrates possible cost-saving benefits associated with continuous resource utilization. Having resources work continuously, however, may require postponements on the start time of resources in certain units. The resulting RSM schedule possesses fewer floats than the early schedule in the Critical Path Method (CPM). The impact of continuous resource utilization on floats is illustrated through an example six-unit project. Since floats can be used to accommodate uncertainty of production rates during planning and variability during execution, fewer floats (buffers) in the planning phase may more likely lead to a longer project duration in the execution phase. A probabilistic model is simulated to compare the impact of the RSM and CPM schedules on the project duration.
Low-current blocking temperature writing of double barrier magnetic random access memory cells (2004)

A magnetic random access memory cell architecture is fabricated where the pinned layer is reversed by heating above a reduced blocking temperature with a current pulse crossing the junction, and cooled under an external applied field (word line), minimizing half-select switching of nonaddressed bits. In order to improve Joule heating and increase breakdown voltage, a double barrier structure was used, with a common antiferromagnetic layer (60 Å MnIr) two pinned 30 Å CoFe layers, and two free layers incorporating nanooxide structures. The blocking temperature was reduced to 120 °C. A TMR of 25% was achieved for both single barrier and double barrier tunnel junctions with resistance×area products of ∼40 Ω×μm2 and ∼280 Ω×μm2, respectively. Pinned layer writing allows the definition of a three-state memory, requiring, however, a destructive read out. A significant improvement of writing efficiency is observed with the double barrier structure. A 10 ns current pulse of 9 mA/μm2 is sufficient to heat the double barrier junctions above the blocking temperature and induce pinned layer switching.
Clinical Results of Lisfranc Joint Fracture-Dislocation (2007)

1996～2004年の間に治療を行ったリスフラン関節脱臼骨折は7例7足（全例男性）で，このうち陳旧例1例を除く6例6足に対し後ろ向き調査を施行した．年齢は21～58歳（平均34.7歳）で，経過観察期間は4～30ヶ月（平均15.3ヶ月）であった．骨折型は Hardcastle 分類で type A は3足，type B は2足，type C は1足で受傷原因は交通事故3足，労働災害3足であった．リスフラン関節脱臼骨折は見逃され陳旧化した場合やリスフラン関節の正確な整復を怠ると疼痛の原因になるため注意が必要である．
On the comparison between OFDM and single carrier modulation with a DFE using a frequency-domain feedforward filter (2002)

Most comparisons between single carrier and multicarrier modulations assume frequency-domain linear equalization of the channel. We propose a new frequency-domain decision feedback equalizer (FD-DFE) for single carrier modulation, which makes use of a data block transmission format similar to that of the orthogonal frequency-division multiplexing with cyclic prefix (OFDM). The scheme is a nonadaptive DFE where the feedforward part is implemented in the frequency domain, while feedback signal is generated by time-domain filtering. Through simulations in a HIPERLAN-2 scenario, we show that FD-DFE yields a capacity very close to that of OFDM. This result is also confirmed by analytical derivations for a particular case. Furthermore, when no channel loading is considered, FD-DFE performs closely to OFDM for the same averaged frame error rate in a coded transmission. Design methods of the FD-DFE are investigated and a reduced complexity technique is developed, with the result that FD-DFE and OFDM have a similar computational complexity in signal processing.
<i>In Vivo</i> Oximeter with Fast Dynamic Response (1962)

An in vivo oximeter which uses as a probe a standard cardiac catheter or a Cournand needle is described. The oxygen saturation is obtained from the light intensities at two wavelengths (805 and 660 mμ) diffusely reflected by the unhemolyzed blood. The light is brought to the tip of the catheter and back again to the proximal end by means of glass fibers. Details of the construction of the instrument and experimental results are given.
Characteristic analysis of eddy-current brake system using the linear Halbach array (2002)

We apply a linear Halbach magnetized mover to an eddy-current braking system for high speed railway applications. On the basis of analytical two-dimensional field solutions considering end effects, this paper deals with the magnetic field, eddy current distribution, forces according to the secondary relative permeability, and conductivity. We also present comparisons between analytical results and experimental data.
Synthesis of a soluble poly(fluorenone) (2006)

The synthesis and characterisation of a soluble poly(fluorenone) is presented, a polymer with high electron affinity with potential for use in plastic electronic devices as an n-type material.
Some Rare Aphids in new Regions in India (1969)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Hormone Binding in Plants (1976)

INTRODUCTION ,,', ,', 268 THE HORMONE· RECEPTOR CONCEPT ', 268 Methods of Assessing Hormone-Receptor Interactions 268 Kinetic Analysis of Hormone Binding ....... ........ ......... ,,. 269 Criteria for Physiologically Meaningful Binding 270 Structural specificity '''''' ..... ,''''', ..... ,''', ,'''''', ........ 270 Kinetic parameters ..... ........ ,,,,.,, ....... ,,,',, 270 Tissue specificity ....... ....... ,''', ........ ..... 270 Binding of Hormones to Cellular Components Other Than Receptors ...... 271 AUXINS ,', ,', ,', ,' ,''''', , ,', ,', ,,.. 271 Autoradiographic Studies ....... ......... ,''','', ..... ........ ,,, 272 Auxin and DNA '. ..... ,'. ..... ,',, ''''''' 272 Interaction of Auxin with RNA ....... ........ 272 Auxin and Nuclei ''' ''''', ''..''''. ,, ......... ,,'',, 274 Auxin and RNA Synthesis ....... ,, 274 Auxin and Protein ........ ........ ... ..., 276 Auxin-Lipid Interactions in Model Systems ,,,,. 277 Binding to Particulate Sub-Cellular Fractions ..... 278 Naphthylphthalamic acid ........ ......... 278 Auxin .... .,, ........ .. ,.. 279 GIBBERELLINS 281 Synthesis of Radioactive Gibberellins ......... ..... 281 In Vivo Binding Studies ,,,,.,,...... 282 In Vitro Binding Studies 282 Model Systems : 283 CYTOKININS 283 Synthesis of Radioactive Cytokinins ....... ....... ..... ......... 283 In Vivo Binding of Cytokinins ..... .,,,,...... 284 In Vitro Binding of Cytokinins . ,,,, 284
CHANGE DETECTION VIA TERRESTRIAL LASER SCANNING (2007)

Burnout in the primary care service takes place when there is a high level of interaction between nurses and patients. Explanatory models based on psychological and personality related variables provide an approximation to level changes in the three dimensions of the burnout syndrome. A categorical-response ordinal logistic regression model, based on a quantitative, crosscutting, multicentre, descriptive study with 242 primary care nurses in the Andalusian Health Service in Granada (Spain) is performed for each dimension. The three models included all the variables related to personality. The risk factor <i>friendliness</i> was significant at population level for the three dimensions, whilst <i>openness</i> was never significant. <i>Neuroticism</i> was significant in the models related to emotional exhaustion and depersonalization, whilst <i>responsibility</i> was significant for the models referred to depersonalization and personal accomplishment dimensions. Finally, <i>extraversion</i> was also significant in the emotional exhaustion and personal accomplishment dimensions. The analysis performed provides useful information, making more readily the diagnosis and evolution of the burnout syndrome in this collective.
Analysis of the Two-Switch Forward Converter with Synchronous Current Doubler Rectifier (2007)

A soft switching two-switch forward converter is presented to achieve zero voltage switching turn-on of switching devices. In the adopted converter, a buck-boost type of active clamp is connected in parallel with the primary winding of transformer. The energy stored in the transformer leakage inductance and magnetizing inductance can be recovered so that the peak voltage stress of switching devices is limited. The resonance between the transient interval of two main and auxiliary switches is used to achieve ZVS turn-on of all switches. The current doubler synchronous rectifier is used in the secondary side of transformer to reduce the root mean square value of output inductor current, transformer secondary winding current and output voltage ripple by cancelling the current ripple of two output inductors. First the circuit configuration and principles of operation are analyzed in detail. The steady state analysis and design consideration are also presented. Finally, experimental results with a laboratory prototype based on a 380 V input and 12 V/30 A output were provided to verify the effectiveness of the proposed converter.
C<sub>26</sub>to C<sub>32</sub>1,3-alkanediols, a Novel Series of Biological Markers Identified in Miocene (17-20 MA) Leaf Fossils and Sediment (1994)

Abstract A novel homologous series of long chain 1,3-alkanediols, ranging from C26 to C32 with strong even/odd predominance has been identified in a Miocene (17-20 million years old) deposit of fossil leaves and enclosing sediments by GC-MS. Their structures are confirmed by synthesis of their C28 homologue.
The Deiodination of the Iodothyronines and of Their Derivatives in Man (1984)

THYROIDAL secretion is the only source of thyroxine (T4) in the human systemic circulation, and in euthyroid man, T4 is the main secretory product of the gland. The metabolic fate of the hormone once thyroidal secretion has occurred is complex and involves deiodination, deamination and decarboxylation of the amino acid side chain, and esterification of the phenolic hydroxyl group with glucuronic or sulfuric acid. These pathways are not to be considered as mutually exclusive, but are interrelated in an exceedingly complex manner. Deiodination of T4 is the most important degradative pathway and accounts for up to 85% of the disposal of the hormone (1–3). At least two major mechanisms exist within the peripheral tissues by which the iodine atoms may be removed from the molecule. Of these, monodeiodination is quantitatively the most important pathway and has been subjected to the most intensive investigation.
SecureCore: A multicore-based intrusion detection architecture for real-time embedded systems (2013)

Security violations are becoming more common in real-time systems - an area that was considered to be invulnerable in the past - as evidenced by the recent W32.Stuxnet and Duqu worms. A failure to protect such systems from malicious entities could result in significant harm to both humans as well as the environment. The increasing use of multicore architectures in such systems exacerbates the problem since shared resources on these processors increase the risk of being compromised. In this paper, we present the SecureCore framework that, coupled with novel monitoring techniques, is able to improve the security of realtime embedded systems. We aim to detect malicious activities by analyzing and observing the inherent properties of the real-time system using statistical analyses of their execution profiles. With careful analysis based on these profiles, we are able to detect malicious code execution as soon as it happens and also ensure that the physical system remains safe.
Speech enhancement in noise and within face mask (microphone array approach) (2002)

In certain communication environments, digital speech transmission systems must work in severe acoustic environments where the noise levels exceeds 110 dB. In other environments, speakers must use an oxygen face mask. In both situations, the intelligibility of encoded speech falls below an acceptable level. We have developed a technique for improving speech quality in these situations. Previous speech improvement methods have focused on processing the corrupted signal after it has been induced by the microphone. These methods have not performed adequately. In our technique, speech anomalies are attenuated by a microphone array before speech and noise become mixed into a signal. Our microphone array prototype has shown excellent performance. In an example of speech taken aboard an E2C aircraft, this noise-canceling microphone array improved the speech-to-noise ratio by as much as 18 dB. When the same technique is used in a face mask, muffled speech was almost completely restored to high quality speech.
Keynote 3 — The past and future of FPGA soft processors (2014)

Summary form only given. Design productivity is still a challenge for reconfigurable computing. It is expensive to port a software workload to RTL, to maintain the RTL as the workload evolves, and to wait for hours to recompile a bitstream after each design change. Soft processors can help mitigate these costs, and provide new pathways to application acceleration. A mid-range FPGA can now host hundreds of soft CPUs and their interconnection network, and such heterogeneous massively parallel processor and accelerator arrays can sustain hundreds of operations, memory accesses, and branches per cycle. This talk will look back on the history and diversity of soft processor cores for FPGAs, and their continuing relevance for the decade ahead. What new tools, IP, and infrastructure will help us to exploit the coming million LUT, 10 TFLOPS FPGAs? Along the way we will revisit an austere design esthetic and an implementation methodology for crafting FPGA-optimized soft cores, and see how the lessons of mapping one processor into one 1995 FPGA can inform us how to design massively parallel programmable accelerators going forward.
Ultra-thin-base Si bipolar transistor using rapid vapor-phase direct doping (RVD) (1992)

A novel doping method called rapid vapor-phase direct doping (RVD) is developed to form ultra-shallow junctions. The base region of a conventional bipolar transistor is formed by this method, and in ultra-narrow 25-nm base is obtained. The Gummel plot of this device shows almost ideal characteristics. This result suggests that this method does not induce any defects which cause a leakage current. RVD is a thermal diffusion method using hydrogen as a carrier gas and B/sub 2/H/sub 6/ as a source gas. In this method, the impurity atoms directly diffuse from the vapor phase into silicon by a rapid thermal process without a boron-glass layer or metallic boron layer. By varying the source gas flow rate, doping time, and temperature, ultra-shallow junctions below 40 nm with controlled surface concentrations are successfully formed. An ultra-shallow 20-nm junction with surface boron concentration of 4*10/sup 18/ cm/sup -3/ is obtained at 800 degrees C for 5 min with B/sub 2/H/sub 6/ flow rate of 30 ml/min.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Rire et sainteté (2005)

Risa y santidad Introduction La visée exemplaire de la littérature hagiographique semble, à priori, ne pas faire bon ménage avec le rire. Ce sont cependant les rapports entre rire et sainteté qui ont été explorés lors du colloque intitulé risa y santidad (1er-2 avril 2004) en mettant en lumière le rire du saint, mais aussi le rire contre le saint (celui du bourreau, par exemple), ou encore le rire à propos du saint, éléments qui, tous, concourent à définir diverses catégories de "rire", depui...
Synthetic Applications of the Titanium-Catalyzed Exchange of Olefins with Grignard Reagents<sup>1a</sup> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic Applications of the Titanium-Catalyzed Exchange of Olefins with Grignard Reagents1aHerman L. Finkbeiner and Glenn D. CooperCite this: J. Org. Chem. 1962, 27, 10, 3395–3400Publication Date (Print):October 1, 1962Publication History Published online1 May 2002Published inissue 1 October 1962https://pubs.acs.org/doi/10.1021/jo01057a003https://doi.org/10.1021/jo01057a003research-articleACS PublicationsRequest reuse permissionsArticle Views592Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Practical Synthesis of <scp>l</scp>-Azatyrosine (1996)

Oncogenic Ras genes and the G-proteins which they encode are important targets for anticancer research. Ras proteins have been implicated to function as components of the cellular signal transduction pathways related to cell proliferation and differentiation. In their oncogenic form, the natural GTP-ase activity of Ras proteins is inhibited, leading to overstimulation of the signaling pathway for cell growth. The potential importance of oncogenic Ras genes and gene products as targets for cancer chemotherapy is underscored by the observation that up to 40% of human colon tumors and 95% of human pancreatic tumors have been found to contain oncogenic Ras genes.
Minute Mechanical-Excitation Wave-Front Propagation in Human Myocardial Tissue (2011)

Complexity of the cardiac contraction sequence is still not fully understood because the dynamic mechanical excitation process, which directly correlates with contraction, cannot be accurately measured based on the electro-magnetic phenomena. By developing a noninvasive novel imaging modality with high temporal and spatial resolutions, the present study shows that the propagation of the mechanical wave-front occurs at the beginning of cardiac contraction sequence for the first time (about 60 ms prior to the ordinarily accepted onset time of the contraction). From the apical side of the interventricular septum, a minute velocity component with an amplitude of several tenth micrometers is generated and it propagates from the apex to the base of the posterior wall, and then from the base to the apex of the septum, with a propagation speed of 3–9 m/s. This dynamic measurement modality is also applicable to various tissues in biology.