gebhart/patrepeval huggingface dataset:
A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum (2003)

B cell antigen receptors (BCRs) are multimeric transmembrane protein complexes comprising membrane-bound immunoglobulins (mIgs) and Ig-alpha/Ig-beta heterodimers. In most cases, transport of mIgs from the endoplasmic reticulum (ER) to the cell surface requires assembly with the Ig-alpha/Ig-beta subunits. In addition to Ig-alpha/Ig-beta, mIg molecules also bind two ER-resident membrane proteins, BAP29 and BAP31, and the chaperone heavy chain binding protein (BiP). In this article, we show that neither Ig-alpha/Ig-beta nor BAP29/BAP31 nor BiP bind simultaneously to the same mIgD molecule. Blue native PAGE revealed that only a minor fraction of intracellular mIgD is associated with high-molecular-weight BAP29/BAP31 complexes. BAP-binding to mIgs was found to correlate with ER retention of chimeric mIgD molecules. On high-level expression in Drosophila melanogaster S2 cells, mIgD molecules were detected on the cell surface in the absence of Ig-alpha/Ig-beta. This aberrant transport was prevented by coexpression of BAP29 and BAP31. Thus, BAP complexes contribute to ER retention of mIg complexes that are not bound to Ig-alpha/Ig-beta. Furthermore, the mechanism of ER retention of both BAP31 and mIgD is not through retrieval from a post-ER compartment, but true ER retention. In conclusion, BAP29 and BAP31 might be the long sought after retention proteins and/or chaperones that act on transmembrane regions of various proteins.
Polyadenylated Messenger RNA in Paired Helical Filament-Immunoreactive Neurons in Alzheimer Disease (1990)

An antibody raised against isolated paired helical filaments (PHF) was used to identify tangle-bearing (PHF+) neurons in autopsy brain tissue from six Alzheimer disease (AD) patients and six age-matched controls (AMC). A comparison of the levels of polyadenylated messenger RNA [poly(A)+ mRNA] in PHF+ and PHF- neurons of similar cross-sectional area in temporal and parietal lobe and cerebellum from four AD and four AMC brains was made by analysis of in situ hybridization of [3H] polyuridylate [poly(U)] to intracellular poly(A)+ mRNA. In PHF+ neurons, the level of poly(A)+ mRNA was approximately two-thirds that in similar-sized PHF- neurons in either AD or AMC. The level of poly(A)+ mRNA in PHF- neurons in regions of the brain that have more of the histopathologically defined effect in AD was similar to that in regions with less effects.
Application of new thermopiezoelectric effect to thermo- and piezoelectret records (2002)

It was originally shown that partially clamped piezoelectric crystals decrease the symmetry of their polarization response to thermal or elastic excitation. As a result any ordinary piezoelectric material (such as /spl alpha/-quartz) and even materials that are pyroelectric perpendicularly to their unique polar axis (such as Y-cut tourmaline) acquire the polar (vectorial) electric response on scalar thermal influence. In connection with this effect we discovered Y-surface thermoinduced electric charges on LiTaO/sub 3/ crystals which manifest themselves through electrooptical patterns. A "thermoelectret" effect is likely to be applied as reversible thermoinduced records. Our recent study uncovered a simple stress-induced method to produce well-defined and reversible records on Y-LiTaO/sub 3/ plates that can be ascribed to a "piezoelectret" nature.
Targeting Histone Deacetylases in Diseases: Where Are We? (2014)

Selective HDACi could achieve enhanced clinical utility by reducing or eliminating the serious side effects associated with current first-generation non-selective HDACi. Isoform-selective and pan-HDACi candidates might benefit from the identification of biomarkers, enabling better patient stratification and prediction of response to treatment.
Descriptions of New South Australian Lepidoptera (1892)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
ChemInform Abstract: Recent Progress Using Chiral Formamidines in Asymmetric Syntheses (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
<i>Chimie Douce</i> Synthesis of a Layered Ammonium Zinc Molybdate (1996)

A layered ammonium zinc molybdate material was derived by a novel room-temperature chimie douce synthesis technique from a metastable mixed oxide prepared by calcination of a layered double hydroxide (LDH). The compound obtained, (NH4)HZn2(OH)2(MoO4)2, is highly crystalline and retains the rhombohedral symmetry of the LDH precursor. The crystal structure of this material was determined by Rietveld refinement of an isostructural ammonium nickel molybdate. The structure is trigonal, with hexagonal unit-cell parameters of a = 6.10767(15) Å and c = 21.6409(6) Å. The host structure consists of divalent cation octahedra which share edges to form layers perpendicular to the c axis, analogous to the LDH precursor. The tetrahedral molybdate species, however, are not merely intercalated within the interlayer domain but are bonded to the layers themselves through shared Mo−O−Zn bonds. This arrangement results in the formation of a net negative charge on the host structure, leading to incorporation of ammonium ions between the layers for charge balancing. The applicability of this novel synthesis route is dependent on the composition of the original LDH, and it appears that metastability in the calcined LDH favors conversion to this phase.
Effects of combinations of 7beta-hydroxycholesterol and anticancer drugs or ionizing radiation on the proliferation of cultured tumor cells. (2002)

Oxysterols compose a large class of natural substances endowed in a number of cases with marked antiproliferative and cytotoxic activities. The consequences of treatments combining 7beta-hydroxycholesterol (7beta-OHC) or XG-142 (a galactose-linked hydrosoluble derivative of 7beta-OHC) with drugs used in cancer chemotherapy or gamma radiation has been evaluated upon a variety of tumor cell lines: Hep-G2, U937, K562 cells, its adriamycin-resistant variant K562 Adr+ and RDM4. Proliferation was assessed by the Uptiblue assay and the [3H]Thymidine incorporation test. Results indicated that 7beta-OHC increased the sensitivity of tumor cells to adriamycin, VP-16, 5-FU and bleomycin to various degrees. 7beta-OHC was found to reinforce the susceptibility of K562 adriamycin-resistant cells to this drug. In RDM4 cells, an enhanced radiosensitivity by 7beta-OHC was also obtained, whereas XG-142 was less efficient in provoking such an effect.
Impact of Nectariless Cotton on Plant Bugs and Natural Enemies1 (1976)

Journal Article Impact of Nectariless Cotton on Plant Bugs and Natural Enemies Get access M. F. Schuster, M. F. Schuster Search for other works by this author on: Oxford Academic PubMed Google Scholar M. J. Lukefahr, M. J. Lukefahr Search for other works by this author on: Oxford Academic PubMed Google Scholar F. G. Maxwell F. G. Maxwell Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 69, Issue 3, 1 June 1976, Pages 400–402, https://doi.org/10.1093/jee/69.3.400 Published: 01 June 1976 Article history Received: 09 December 1975 Published: 01 June 1976
Formal Modeling of Elastic Service-Based Business Processes (2013)

Cloud environments are being increasingly used for deploying and executing business processes and particularly service-based business processes (SBPs). One of the expected facilities of Cloud environments is elasticity at different levels. In this work, we argue the need of supporting elasticity at the service level. We propose a formal model for describing elasticity mechanisms and their strategies for SBPs. Our contribution consists in composing SBP models with models of controllers that describe the behavior of services and container replicas. In addition, we provide means for specifying both reactive and predictive elasticity strategies.
Huntington's and myotonic dystrophy hESCs: down-regulated trinucleotide repeat instability and mismatch repair machinery expression upon differentiation (2010)

Huntington's disease (HD) and myotonic dystrophy (DM1) are caused by trinucleotide repeat expansions. The repeats show different instability patterns according to the disorder, cell type and developmental stage. Here we studied the behavior of these repeats in DM1- and HD-derived human embryonic stem cells (hESCs) before and after differentiation, and its relationship to the DNA mismatch repair (MMR). The relatively small (CAG)44 HD expansion was stable in undifferentiated and differentiated HD hESCs. In contrast, the DM1 repeat showed instability from the earliest passages onwards in DM1 hESCs with (CTG)250 or (CTG)1800. Upon differentiation the DM1 repeat was stabilized. MMR genes, including hMSH2, hMSH3 and hMSH6 were assessed at the transcript and protein levels in differentiated cells. The coincidence of differentiation-induced down-regulated MMR expression with reduced instability of the long expanded repeats in hESCs is consistent with a known requirement of MMR proteins for repeat instability in transgenic mice. This is the first demonstration of a correlation between altered repeat instability of an endogenous DM1 locus and natural MMR down-regulation, in contrast to the commonly used murine knock-down systems.
Enhanced Contrast of Wavelength-Selective Mid-Infrared Detectors Stable against Incident Angle and Temperature Changes (2011)

A thermal infrared detector with enhanced contrast of its wavelength-selective function has been fabricated. A 2 ×2-mm2-size detector with p++-Si–Pt thermopiles on a Si substrate is the base device. A polymer material is deposited on the hot junctions of the thermopiles, working as a wavelength-selective absorber to integrate spectroscopic function into the thermopile detector. The polymer used is polyacrylonitrile (PAN), with a sharp isolated absorption peak at a wavelength of 4455 nm; the detector shows +35% output increase from the baseline at this wavelength. Very little dependence of the center wavelength (CWL) on the incident angle has been confirmed. Temperature dependencies were measured over the range from 20 to 80 °C. The detector shows a smaller CWL shift, which is ∼1/20 of that of the conventional detector using an optical bandpass filter with a dielectric multilayer on a Si substrate. These features are suitable for miniaturizing the sensor module including the optical setups.
Forward-link CDMA resource allocation based on pricing (2002)

This paper studies pricing as a means for resource allocation in a wireless direct-sequence (DS) code division multiple access (CDMA) system. We consider the forward link of a single cell with orthogonal codes and voice traffic. The base station announces a price per unit transmitted power and a price per code, and the users respond according to their individual utilities. The objective is to set prices to maximize either total user utility or total revenue. The solution to the former problem (maximize utility) is presented. To study the latter problem we derive the large system revenue as the number of users and codes tend to infinity with fixed ratio. The large system revenue depends on the distribution of utilities and path loss across the user population, and may not be a unimodal function of the prices. Numerical results based on a simple model for user utility show how the optimal prices and revenue vary with the offered load.
Long‐term strength of ceramics for biomedical applications (2004)

The influence of slow crack growth on the initiation of radial cracks at the lower surfaces of ceramic layers bonded to polymeric substrates is studied, with particular relevance to biomechanical systems, e.g., dental crowns and hip replacement prostheses. Critical loads are measured as a function of loading rate (dynamic fatigue) for model bilayers fabricated by epoxy-bonding selected clinical ceramics to polycarbonate bases. Radial crack initiation is observed in situ by viewing from below the transparent base during loading. Declines in the critical loads with diminishing load rate are consistent with slow crack growth of intrinsic flaws prior to radial crack pop in. A simple fracture mechanics relation incorporating a crack velocity function is used to analyze the data. Extrapolation beyond the data range enables long-lifetime (10 yr) estimates of sustainable loads. The procedure provides a basis for ranking ceramic types, and in particular for eliminating vulnerable candidate materials, for use in biomechanical systems. While slow crack growth is an important factor in failure, other mechanisms could operate in concert and even dominate under severe testing conditions, especially under cyclic loading.
Efficacy of systemic temozolomide‐activated phage‐targeted gene therapy in human glioblastoma (2019)

Glioblastoma multiforme (GBM) is the most lethal primary intracranial malignant neoplasm in adults and most resistant to treatment. Integration of gene therapy and chemotherapy, chemovirotherapy, has the potential to improve treatment. We have introduced an intravenous bacteriophage (phage) vector for dual targeting of therapeutic genes to glioblastoma. It is a hybrid AAV/phage, AAVP, designed to deliver a recombinant adeno-associated virus genome (rAAV) by the capsid of M13 phage. In this vector, dual tumor targeting is first achieved by phage capsid display of the RGD4C ligand that binds the α<sub>v</sub>β<sub>3</sub> integrin receptor. Second, genes are expressed from a tumor-activated and temozolomide (TMZ)-induced promoter of the glucose-regulated protein, <i>Grp78</i> Here, we investigated systemic combination therapy using TMZ and targeted suicide gene therapy by the RGD4C/AAVP-<i>Grp78</i> Firstly, <i>in vitro</i> we showed that TMZ increases endogenous <i>Grp78</i> gene expression and boosts transgene expression from the RGD4C/AAVP-<i>Grp78</i> in human GBM cells. Next, RGD4C/AAVP-<i>Grp78</i> targets intracranial tumors in mice following intravenous administration. Finally, combination of TMZ and RGD4C/AAVP-<i>Grp78</i> targeted gene therapy exerts a synergistic effect to suppress growth of orthotopic glioblastoma.
Physiological and seed yield responses to water deficits among lentil genotypes from diverse origins (2006)

The effect of water deficits at 2 growth stages on the physiology and growth of lentil (Lens culinaris Medikus subsp. culinaris) genotypes bred/selected for 3 regions was examined in a glasshouse experiment. The water regimes imposed were: (i) a well-watered control, (ii) water withheld at flowering, from 72 to 93 days after sowing (DAS), and (iii) water withheld from podding (93 DAS) to maturity. The genotypes were a West Asian genotype released in Australia (Cassab), 2 South Asian Nepali cultivars (Khajura 2 and Simal), and 3 crossbreds between West Asian and South Asian parents (ILL 6829, ILL 7979, and ILL 7982). ILL 7979 and Simal had significantly greater total dry matter, water use, seed yield, number of pods and seeds per plant, and harvest index (HI) than the other genotypes under well-watered conditions. Water deficits reduced seed yield by up to 60% in the crossbreds and the South Asian cultivar, Simal. However, seed yield was increased by the water deficit at flowering and the water deficit at podding in the West Asian genotype, Cassab, and the South Asian genotype, Khajura 2, respectively. In the other genotypes, withholding water at flowering or podding reduced leaf area (48–55%), total dry matter (32–50%), flower production (22–55%), and number of pods and seeds (27–66%), with significantly higher flower drop and empty pods when water was withheld. The higher seed yield in Cassab and Khajura 2 when water was withheld was related to the production of more flowers and the maintenance of pod and seed set when they were re-watered after the period of water deficit. When water was withheld during flowering, the West Asian genotype Cassab and the crossbred ILL 6829 used less water and hence maintained a high leaf water potential (?leaf), whereas ?leaf decreased earlier to lower values in the crossbred ILL 7979 and the South Asian genotypes Khajura 2 and Simal. There were no significant differences in leaf net photosynthesis (PN), or stomatal conductance (gS), among genotypes during flowering and early podding, but PN and gS were reduced by 22–38 and 19–67%, respectively, when water was withheld. The lower ?leaf in ILL 7979, Simal, and Khajura 2 induced greater osmotic adjustment (OA) during the drying cycle at flowering, whereas there was no or little OA when water was withheld at podding. Variation in physiological traits (PN, gS, OA) under both watering regimes was not directly related to seed yield, but seed number was related to seed yield under both well-watered and water-deficit conditions.
Periodic Faraday Bias and Lock-In Phenomena in a Laser Gyro (1973)

A simple theoretical description of coupling phenomena in a laser gyro has been developed. In particular, this allows the calculation of the residual nonlinearity of the response of the laser gyro in the presence of a periodic bias. A laser gyro has been constructed in a CER-VIT block. To solve the lock-in zone problem this detector contains a periodic bias system using the Faraday effect. The results of a number of trials are reported. In particular, we obtain experimental values of residual error due to coupling phenomena for each rotational speed. These results are in good agreement with a simple coupled oscillators theory.
Sorafenib: activity and clinical application in patients with hepatocellular carcinoma (2011)

With the approval of sorafenib being given the significance of a milestone, systemic treatment of HCC is no longer regarded as ineffective. The tyrosine kinase inhibitor, sorafenib, gives us new hope for successful cancer therapy.
Quantum mechanical theory of dynamic nuclear polarization in solid dielectrics (2011)

Microwave driven dynamic nuclear polarization (DNP) is a process in which the large polarization present in an electron spin reservoir is transferred to nuclei, thereby enhancing NMR signal intensities. In solid dielectrics there are three mechanisms that mediate this transfer--the solid effect (SE), the cross effect (CE), and thermal mixing (TM). Historically these mechanisms have been discussed theoretically using thermodynamic parameters and average spin interactions. However, the SE and the CE can also be modeled quantum mechanically with a system consisting of a small number of spins and the results provide a foundation for the calculations involving TM. In the case of the SE, a single electron-nuclear spin pair is sufficient to explain the polarization mechanism, while the CE requires participation of two electrons and a nuclear spin, and can be used to understand the improved DNP enhancements observed using biradical polarizing agents. Calculations establish the relations among the electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR) frequencies and the microwave irradiation frequency that must be satisfied for polarization transfer via the SE or the CE. In particular, if δ, Δ < ω(0I), where δ and Δ are the homogeneous linewidth and inhomogeneous breadth of the EPR spectrum, respectively, we verify that the SE occurs when ω(M) = ω(0S) ± ω(0I), where ω(M), ω(0S) and ω(0I) are, respectively, the microwave, and the EPR and NMR frequencies. Alternatively, when Δ > ω(0I) > δ, the CE dominates the polarization transfer. This two-electron process is optimized when ω(0S(1))-ω(0S(2)) = ω(0I) and ω(M)~ω(0S(1)) or ω(0S(2)), where ω(0S(1)) and ω(0S(2)) are the EPR Larmor frequencies of the two electrons. Using these matching conditions, we calculate the evolution of the density operator from electron Zeeman order to nuclear Zeeman order for both the SE and the CE. The results provide insights into the influence of the microwave irradiation field, the external magnetic field, and the electron-electron and electron-nuclear interactions on DNP enhancements.
Development of a low-power microwave atmospheric pressure molecular ionization source for mass spectrometry with direct introduction of gaseous and liquid organic samples (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDevelopment of a low-power microwave atmospheric pressure molecular ionization source for mass spectrometry with direct introduction of gaseous and liquid organic samplesWei Lung. Shen and R. D. SatzgerCite this: Anal. Chem. 1991, 63, 18, 1960–1964Publication Date (Print):September 15, 1991Publication History Published online1 May 2002Published inissue 15 September 1991https://pubs.acs.org/doi/10.1021/ac00018a012https://doi.org/10.1021/ac00018a012research-articleACS PublicationsRequest reuse permissionsArticle Views130Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SmartPort: A Platform for Sensor Data Monitoring in a Seaport Based on FIWARE (2016)

Seaport monitoring and management is a significant research area, in which infrastructure automatically collects big data sets that lead the organization in its multiple activities. Thus, this problem is heavily related to the fields of data acquisition, transfer, storage, big data analysis and information visualization. Las Palmas de Gran Canaria port is a good example of how a seaport generates big data volumes through a network of sensors. They are placed on meteorological stations and maritime buoys, registering environmental parameters. Likewise, the Automatic Identification System (AIS) registers several dynamic parameters about the tracked vessels. However, such an amount of data is useless without a system that enables a meaningful visualization and helps make decisions. In this work, we present SmartPort, a platform that offers a distributed architecture for the collection of the port sensors’ data and a rich Internet application that allows the user to explore the geolocated data. The presented SmartPort tool is a representative, promising and inspiring approach to manage and develop a smart system. It covers a demanding need for big data analysis and visualization utilities for managing complex infrastructures, such as a seaport.
Numerical Differentiation of Noisy, Nonsmooth Data (2011)

We consider the problem of differentiating a function specified by noisy data. Regularizing the differentiation process avoids the noise amplification of finite-difference methods. We use total-variation regularization, which allows for discontinuous solutions. The resulting simple algorithm accurately differentiates noisy functions, including those which have a discontinuous derivative.