gebhart/patrepeval huggingface dataset:
Biodegradable polyesters reinforced with triclosan loaded polylactide micro/nanofibers: Properties, release and biocompatibility (2012)

Mechanical properties and drug release behavior were studied for three biodegradable polyester matrices (polycaprolactone, poly(nonamethylene azelate) and the copolymer derived from 1,9-nonanediol and an equimolar mixture of azelaic and pimelic acids) reinforced with polylactide (PLA) fibers. Electrospinning was used to produce suitable mats constituted by fibers of different diameters (i.e. from micro-to nanoscale) and a homogeneous dispersion of a representative hydrophobic drug (i.e. triclosan). Fabrics were prepared by a molding process, which allowed cold crystallization of PLA micro/nanofibers and hot crystallization of the polyester matrices. The orientation of PLA molecules during electrospinning favored the crystallization process, which was slightly enhanced when the diameter decreased. Incorporation of PLA micro/nanofibers led to a significant increase in the elastic modulus and tensile strength, and in general to a decrease in the strain at break. The brittle fracture was clearer when high molecular weight samples with high plastic deformation were employed. Large differences in the release behavior were detected depending on the loading process, fiber diameter size and hydrophobicity of the polyester matrix. The release of samples with the drug only loaded into the reinforcing fibers was initially fast and then became slow and sustained, resulting in longer lasting antimicrobial activity. Biocompatibility of all samples studied was demonstrated by adhesion and proliferation assays using HEp-2 cell cultures.
Acute, dose‐dependent cognitive effects of <i>Ginkgo biloba, Panax ginseng</i> and their combination in healthy young volunteers: differential interactions with cognitive demand (2002)

The present paper describes three studies examining the acute effects of single doses of Ginkgo biloba (GK501), Ginseng (G115) and their combination (Ginkoba M/E, Pharmaton SA) on the performance of healthy young adults (mean age 21 years) during serial arithmetic tasks with differing cognitive load. In each double-blind, placebo-controlled study three different treatment doses and a placebo were administered, according to a balanced crossover design, with a 7-day washout period between each dose. Participants' scores on two computerised serial subtraction tasks (Serial Threes and Serial Sevens) were assessed pre-dosing and at 1, 2.5, 4 and 6 h thereafter. A number of significant time, dose and task-specific effects were associated with each treatment. There was a dose-dependent improvement in speed of responding during Serial Threes following Ginkgo biloba. Different doses of Ginseng improved accuracy and slowed responses during Serial Sevens. The most striking result, however, was a highly significant and sustained increase in the number of Serial Sevens responses following 320 mg of the Ginkgo-Ginseng combination at all post-treatment testing times. This was accompanied by improved accuracy during Serial Sevens and Serial Threes following the 640 mg and the 960 mg dose, respectively. The paper concludes with speculation into the possible mechanisms underlying these effects.
Komplexone I. Über die Salzbildung der Nitrilotriessigsäure (1945)

Abstract 1. Die Aciditätskonstanten der Nitrilo‐triessigsäure werden angegeben und auf die verschiedenartige Konstitution der Säure und ihrer Anionen wird aufmerksam gemacht.
Considerations in the selection of security measures for automatic data processing systems (1978)

The authors introduce the readers to presently known methods and techniques for protecting data in an ADP facility and during transmission.
Receptor affinity purification of a lipid-binding adhesin from Helicobacter pylori (1993)

Our previous work has shown that Helicobacter pylori specifically recognizes gangliotetraosylceramide, gangliotriaosylceramide, and phosphatidylethanolamine in vitro. This binding specificity is shared by exoenzyme S from Pseudomonas aeruginosa, and monoclonal antibodies against this adhesin prevent the attachment of H. pylori to its lipid receptors. We now report the use of a novel, versatile affinity matrix to purify a 63-kDa exoenzyme S-like adhesin from H. pylori which is responsible for the lipid-binding specificity of this organism.
Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction (2020)

This study provides an overview of postmortem findings in COVID-19 cases, implying that hypertensive, elderly, obese, male individuals with severe cardiovascular comorbidities as well as those with blood group A may have a lower threshold of tolerance for COVID-19. This provides a pathophysiological explanation for higher mortality rates among these patients.
Chemometric methods to classify stationary phases for achiral packed column supercritical fluid chromatography (2012)

SUMMARY This paper investigates classification models for packed columns used in supercritical fluid chromatography (SFC). Forty‐eight columns of varied stationary phase chemistries available on the market are evaluated. The retention factors of 134 selected test compounds are used to compute hierarchical cluster analysis (HCA), principal component analysis (PCA), and quantitative structure–retention relationships (QSRRs). The use of HCA in conjunction with either PCA of QSRRs provides a classification of columns that is consistent with the experience of the SFC chromatographer. Besides, different coefficients, namely, Pearson correlation coefficient ( r ), selectivity difference ( s 2 ), distance ( L ), and angle ( θ ), were calculated between all couples of columns to identify a ranking index, which would provide meaningful information whenever two columns need to be compared on an objective basis. This can be the case either when an equivalent is sought for replacement of a reference column or when an orthogonal column is desired to achieve complementary selectivity. It is concluded that the θ angle and the normalized distance L /u are the best coefficients, allowing for a meaningful comparison between two columns. Copyright © 2012 John Wiley & Sons, Ltd.
The Doctrine of Signatures or Similitudes: A Comparison of the Efficacy of Praziquantel and Traditional Herbal Remedies Used for the Treatment of Urinary Schistosomiasis in Zimbabwe (1994)

The Doctrine of Signatures or Similitudes simply states that “like cures like” and each medicinal product from nature indicates by an obvious and well-marked character the disease for which it is a remedy or the object for which it can be employed. The Doctrine exerted influence in Europe until late in the 17th century and still does so in most parts of Africa including Zimbabwe. Medicinal plants found, from interviewing traditional healers, to be commonly used for the treatment of Schistosoma haematobium, most of which produce either red seeds, red sap or red extract, were collected and investigated for their anti-schistosoma activities. The plant materials were prepared according to the guidelines of the traditional healers and their efficacy was determined by administering the crude extracts to laboratory animals infected with S. haematobium. The results suggested that plant extracts from Abrus precatorius L., Pterocarpus angolensis DC. and Ozoroa insignis Del. complied with the apparent signatures.
Building an AS-topology model that captures route diversity (2006)

An understanding of the topological structure of the Internet is needed for quite a number of networking tasks, e. g., making decisions about peering relationships, choice of upstream providers, inter-domain traffic engineering. One essential component of these tasks is the ability to predict routes in the Internet. However, the Internet is composed of a large number of independent autonomous systems (ASes) resulting in complex interactions, and until now no model of the Internet has succeeded in producing predictions of acceptable accuracy.We demonstrate that there are two limitations of prior models: (i) they have all assumed that an Autonomous System (AS) is an atomic structure - it is not, and (ii) models have tended to oversimplify the relationships between ASes. Our approach uses multiple quasi-routers to capture route diversity within the ASes, and is deliberately agnostic regarding the types of relationships between ASes. The resulting model ensures that its routing is consistent with the observed routes. Exploiting a large number of observation points, we show that our model provides accurate predictions for unobserved routes, a first step towards developing structural mod-els of the Internet that enable real applications.
Helium-Gaskryostat zur Messung der optischen Doppelbrechung bei magnetischen und strukturellen Phasenübergängen (1972)

Article Helium-Gaskryostat zur Messung der optischen Doppelbrechung bei magnetischen und strukturellen Phasenübergängen was published on December 1, 1972 in the journal Zeitschrift für Kristallographie - Crystalline Materials (volume 136, issue 1-6).
Spilt-Join and Message Passing Programming Models on the BBN TC2OOO. (1991)

The BBN TC2000 is a scalable general purpose parallel architecture capable of efficiently supporting both shared memory and message passing programming paradigms. We describe the TC2000 machine architecture and the programming models which we have implemented on it. The parallel programming models are implemented in a portable manner and will be useful on the scalable shared memory machines we expect to see in the future. 14 refs.
Expression of Carcinoembryonic Antigen Cell Adhesion Molecule 6 Oncoprotein in Atypical Ductal Hyperplastic Tissues Is Associated with the Development of Invasive Breast Cancer (2006)

The expression of CEACAM6 in ADH lesions is strongly associated with the development of IBC, therefore, it can be applied as a diagnostic marker either singly or in combination with other marker(s) to predict IBC development in women with ADH lesions. It could also be a potential molecular therapeutic target for preventing IBC.
Potent antitumor effect of SN‐38‐incorporating polymeric micelle, NK012, against malignant glioma (2008)

Abstract Recent published reports on clinical trials of CPT‐11 indicate the effectiveness of this compound, a prodrug of SN‐38, against malignant glioma in combination with anti‐vascular endothelial growth factor antibody. Here, we determined if NK012, and SN‐38 incorporating micelle, can be an appropriate formulation for glioblastoma treatment compared with CPT‐11. In vitro cytotoxicity was evaluated against several glioma lines with NK012, CPT‐11, SN‐38, ACNU, CDDP and etoposide. For the in vivo test, a human glioma line (U87MG) transfected with the luciferase gene was inoculated into nude mice brain for pharmacokinetic analysis by fluorescence microscopy and high‐performance liquid chromatography after intravenous injection of NK012 and CPT‐11. In vivo antitumor activity of NK012 and CPT‐11 was evaluated by bioluminescence image and Kaplan‐Meier analyses. The growth‐inhibitory effects of NK012 were 34‐ to 444‐fold more potent than those of CPT‐11. Markedly enhanced and prolonged distribution of free SN‐38 in the xenografts was observed after NK012 injection compared with CPT‐11. NK012 showed significantly potent antitumor activity against an orthotopic glioblastoma multiforme xenograft and significantly longer survival rate than CPT‐11 ( p = 0.0014). This implies that NK012 can pass through the blood brain tumor barrier effectively. NK012, which combines enhanced distribution with prolonged sustained release, may be ideal for glioma treatment. Currently, a phase I study of NK012 is almost complete in Japan and the US. The present translational study warrants the clinical phase II study of NK012 in patients with malignant glioma. © 2008 Wiley‐Liss, Inc.
Novel voa using in-plane reflective micromirror and off-axis light attenuation (2003)

A new off-axis light attenuation configuration combining with a movable reflective micromirror is proposed for variable optical attenuator (VOA) application. Comprehensive study of new comb drive actuators of a two-step structure is done to achieve large displacement of an actuated micromirror for VOA. The measured optical and electrical performances have proven this new design promising for practical applications.
Polar Constituents of <i>Marrubium thessalum</i> Boiss. & Heldr. (Lamiaceae) and their Cytotoxic/Cytostatic Activity (2012)

The methanol extract of the aerial parts of Marrubium thessalum Boiss. & Heldr. (Lamiaceae) afforded 30 phenolic metabolites, belonging to the classes of phenylethanoid glycosides, flavonoids and simple phenolic compounds. The crude methanol extract as well as the secondary metabolites were screened for their cytotoxic/cytostatic effects against four human cancer cell lines, specifically HeLa, MCF-7, FM3 and HCT-116 and demonstrated considerable cell growth-inhibitory activity. The differential cytotoxicity of the compounds implied possible structure-activity relationships. Selected compounds were evaluated for their toxicity against human peripheral blood mononuclear cells, where some of them showed marginal toxic effects. The results suggest that M. thessalum produces secondary metabolites that demonstrate selective anticancer activity concomitantly with reduced toxicity on lymphocytes. The structure of such compounds can eventually lead to the development of novel pharmaceutical agents.
Effect of melanoma intrinsic β-catenin signaling on immune exclusion and resistance to immunotherapies. (2015)

9014 Background: A subset of metastatic melanoma patients shows evidence for a T cell-inflamed tumor microenvironment at baseline, which has prognostic value and is associated with clinical response to immunotherapies including anti-PD-1. However, the molecular mechanisms mediating the absence of T cell infiltration in a major subset of patients have not been defined. Methods: Exome sequencing and gene expression profiling of melanoma metastases (TCGA) was combined with mechanistic studies in genetically engineered mouse models. Results: Analysis of melanoma metastases samples using gene expression profiling and exome sequencing, revealed activation of Wnt/ß-catenin pathway in a major subset of non-T cell-inflamed tumors. Using genetically engineered mouse melanoma models (BrafV600E/PTEN-/-± active ß-catenin), we demonstrated a causal effect between tumor-intrinsic ß-catenin signaling and T cell exclusion from the tumor microenvironment. The mechanism was via failed production of the chemokine CCL4, which was associated with failed recruitment of Batf3-lineage dendritic cells. Mice with these non-T cell-inflamed melanomas failed to respond to anti-CTLA-4/anti-PD-L1 mAb therapy. Active Wnt/ß-catenin signature in human melanomas was associated with reduction of Batf3 dendritic cell transcripts. Clinically, a patient who responded to a melanoma vaccine then recurred showed selection for loss of the T cell signature and gain of the ß-catenin phenotype. Conclusions: We have for the first time identified an oncogenic pathway that directly mediates immune evasion, which is implicated in examples of both primary and acquired resistance to immunotherapies.
Suppression of human monocyte interleukin 1 production by the plant alkaloid tetrandrine. (1989)

The bisbenzylisoquinoline alkaloid, tetrandrine, was shown to affect some important human monocyte functions. The drug caused significant inhibition of random movement, chemotaxis, superoxide anion generation and interleukin 1 (IL-1) production. By contrast, degranulation and hexose-monophosphate shunt activity were unaffected. Tetrandrine may be of value in the treatment of chronic inflammatory diseases where IL-1 has a major role as an inflammatory mediator.
Query refinement for ontology information extraction (2016)

Ontology information extraction has gain popularity due to the increasing amount of ontologies developed over the years. World Wide Web Consortium (W3C) has introduced SPARQL query language to extract information. However SPARQL query language follow a specific pattern in order to find the triple through subgraph matching. The keywords used in the SPARQL query have to be exactly same as the existing keywords in the RDF data in-order to extract the required information. The paper introduced a method to ease the job of the user by generating SPARQL query from the query entered by the user. The method uses the object property list generated from the ontology and word's synonym to aid in SPARQL query generation. The result has shown that the proposed method clearly eases the need of the user to learn SPARQL syntax.
Growth and characterization of Indium-doped silicon for extrinsic IR detectors (1980)

Experimental growth and characterization studies of extrinsic indium-doped silicon for 3- to 5-µm focal-plane array applications have been carried out. Large, 2- and 3-in-diameter, -oriented indium-doped silicon crystals were prepared by Czochralski crystal pulling. The growth conditions affecting crystalline perfection, maximum dopant concentration and uniformity, and the residual shallow acceptor impurity content in grown crystals were investigated. In addition, effects of carbon content on the concentration of the 0.11-eV defect level in indium-doped silicon have been studied. The results demonstrate that near dislocation-free crystals containing indium concentrations up to 5 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">17</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> can be achieved at low growth rates to delay the onset of constitutional supercooling, while unwanted boron and aluminum impurities can be maintained at levels approaching 1 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">13</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> , when high purity synthetic-quartz crucibles are utilized to minimize melt contamination. Phosphorus-compensated indium-doped infrared (IR) detector performance and test photodetectors show peak responsivities up to 10 A/W (5.9 µm, 1000 V/cm, 50 K). Monolithic CCD test structures fabricated on Czochralski indium-doped silicon substrates show lower responsivities, however, due to detrimental effects of high-temperature CCD processing.
Is there a requirement for glutamine catabolism in the small intestine? (1999)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Specifying and enforcing constraints in role-based access control (2003)

Constraints in access control in general and separation of duty constraints in particular are an important area of research. There are two important issues relating to constraints: their specification and their enforcement. We believe that existing separation of duty specification schemes are rather complicated and that the few enforcement models that exist are unlikely to scale well.We examine the assumptions behind existing approaches to separation of duty and present a combined specification and implementation model for a class of constraints that includes separation of duty constraints. The specification model is set-based and has a simpler syntax than existing approaches. We discuss the enforcement of constraints and the relationship between static, dynamic and historical separation of duty constraints. Finally, we propose a model for a scalable role-based reference monitor, based on dynamic access control structures, that can be used to enforce constraints in an efficient manner.
Experimental Studies of Secondary Electron Emission of TiO<sub>2</sub> and Ti (2006)

Secondary electron emission yield, δ, was measured as a function of primary electron energy, E P , using an Auger electron microscope to obtain the δ( E P ) curve of TiO 2 for the first time. As a reference, the δ( E P ) curve was also measured for Ti to verify the accuracy of this experiment. The construction of a specific sample holder was carried out for the precise measurement of secondary electron emission. The maximum secondary electron yield δ m =1.2 at E P =260 eV for TiO 2 whereas δ m =0.9 at E P =280 eV for Ti.
Maintaining Normal Hemoglobin Levels With Epoetin Alfa in Mainly Nonanemic Patients With Metastatic Breast Cancer Receiving First-Line Chemotherapy: A Survival Study (2005)

In this trial, the use of epoetin alfa to maintain high Hb targets in women with MBC, most of whom did not have anemia at the start of treatment, was associated with decreased survival. Additional research is required to clarify the potential impact of erythropoietic agents on survival when the Hb target range is 10 to 12 g/dL.
Coreless substrate technology investigation for ultra-thin CPU BGA packaging (2012)

Coreless packaging is an attractive option to meet the low z-height requirements typically demanded in low-profile mobile devices. In order to deliver high quality, fully functional assembled coreless packages several aspects of this technology need to be studied to understand the benefits and the drawbacks. Towards realizing this goal, a prototype coreless BGA package for an existing product was designed, fabricated, and characterized for power delivery and IO signal integrity. A comparative study of performance was performed on a 45nm CPU in a coreless BGA package, and compared to the same 45nm CPU in the standard cored BGA. This paper reviews the design strategies implemented and characterization data collected to achieve matched electrical performance with the existing cored package. The paper first makes comparisons between cored and coreless designs and then presents the detailed physical design concepts. Next the paper focuses on electrical performance analysis including both IO performance and power delivery analysis, and then reviews the validation data collected. The results of this study show that the IO performance is comparable between the cored and coreless packages for both microstrip and the stripline routing for both DDR3 and PCI Express Gen 2. Additionally, the power delivery study shows that the expected benefit from the removal of PTH's is compromised in this prototype design due to the removal of die side capacitors and the reduction in the total number of land side capacitors. This made the coreless DC loadline virtually unchanged when compared to the cored package.
Potential for Glucose Monitoring with Nanoengineered Fluorescent Biosensors (2002)

Possibilities for engineering of fluorescent micro/nanoscale devices for glucose sensing are presented. A description of the potential for clinical use is given in terms of overall concept, current knowledge, advantages of the fabrication approach proposed, and challenges that must be addressed prior to clinical use. Deployment of micro/nanoparticles in the dermis may allow transdermal monitoring of glucose changes in interstitial fluid. Using electrostatic self-assembly, an example of nanotechnology for fabrication, two types of sensors are being studied: (1). solid nanoparticles coated with fluorescent enzyme-containing thin films and (2). hollow micro/nanocapsules containing fluorescent indicators and enzymes or glucose-binding proteins. Nanoengineering of the coated colloids and microcapsules allows precision control over optical, mechanical, and catalytic properties to achieve sensitive response using a combination of polymers, fluorescent indicators, and glucose-specific proteins. Challenges to in vivo use include understanding of material toxicity and failure modes, and determining methods to overcome fouling, protein inactivation, and material degradation.