gebhart/patrepeval huggingface dataset:
The development of diphosphonates as significant health care products (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe development of diphosphonates as significant health care productsMarion D. Francis and Rosemary L. Centner Cite this: J. Chem. Educ. 1978, 55, 12, 760Publication Date (Print):December 1, 1978Publication History Received3 August 2009Published online1 December 1978Published inissue 1 December 1978https://doi.org/10.1021/ed055p760RIGHTS & PERMISSIONSArticle Views160Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (5 MB) Get e-Alerts Get e-Alerts
Radioimmunoassay of Melatonin: Human Serum and Cerebrospinal Fluid (1977)

Using a newly characterized anti-melatonin serum it has been possible to establish human serum melatonin concentrations at short time intervals during 24h. A clear circadian rhythm with peak values during the dark phase was demonstrated in both men and women. Values (pg/ml;mean +/- SE) were as follows: females 02.00h: 130 +/- 7, 18.00h: 45 +/- 5 males 02.00h: 140 +/- 11, 18,00H: 70 +/- 5. The estimation (pg/ml; mean +/- SE) of melatonin in human serum (males: 63 +/- 22 and females: 100 +/- 45) and cerebrospinal fluid simultaneously taken has shown that melatonin is lower in cerebrospinal fluid (males: 59 +/- 33 and females: 57 +/- 28). Blanks are not subtracted.
Approach to assessment of risk to human health for priority substances under the Canadian environmental protection act (1994)

Abstract The Canadian Environmental Protection Act (CEPA) authorizes the Ministers of the Environment and of Health in Canada to investigate a wide variety of substances that may contaminate the environment and cause adverse effects on the environment and/or on human health. Under the Act, 44 substances have been identified, for which priority must be given in assessing potential effects on the environment and human health. In this paper, the principles developed for the approach to assessment of risks to human health associated with exposure of the general population to Priority Substances under CEPA are outlined. These include the development of multimedia exposure estimates, classification of substances on the basis of the nature of the critical effect and the approach to evaluation for substances with different types of critical effects.
Building flexible mobile applications for next generation enterprises (2002)

In order to understand and gain practical insights into various aspects of next-generation enterprises (NGEs), we are building a testbed for flexible mobile applications. We started with a generic architecture and used it to build different applications in different domains. Our testbed consists of a multi-tiered architecture incorporating various user interfaces and access technologies, middleware components, enterprise integration systems, supply chain management and a host of currently emerging technologies. The first application we have developed is an information application for the Olympic Games to provide personalized information for mobile users through a variety of end-user devices. The second experiment is a typical e-commerce online purchasing application that uses mobile agents (brokers) to buy products from multiple suppliers based on user-specified criteria. The third example demonstrates a typical workflow scenario that may be needed in a highly collaborative and reliable NGE environment. In this paper, we present our preliminary experiences in building these applications. Based on our experience, we are pursuing further research and evaluation of various technologies for flexibility, mobility, scalability and ease of integration.
Applications of electro-optic and laser technology to fluorescence microscopy (1995)

A confocal attachment (Odyssey) to an inverted microscope was modified to better study living cultured epithelial cells stained with fluorescent dyes. Improvements to the instrument included elimination of light leaks, improved electronic shielding, reduction of thermal effects and use of low dark current detectors. In addition, rapid changes in illumination wavelength and power were accomplished by replacing the original mechanical filter changer by an acousto-optic tunable filter attached to the argon laser light source. The addition of a liquid crystal tunable filter to one of the two photomultiplier detectors also permitted rapid spectral scanning of the fluorescence emission. High resolution, differential interference contrast transmitted light images were formed simultaneously by replacement of the photodiode-based transmitted light detector with a photomultiplier tube and dichroic mirror assembly. An illumination intensity of only 40 μW/cm2 at the back focal plane of the microscope objective allowed high quality fluorescence and transmitted light images of living cells at video rates with minimal bleaching and photodynamic damage. Both excitation ratio imaging and emission spectral scanning of living epithelial cells were accomplished. The system performance was evaluated by optical sections of fluorescent beads and thin films.
New Synthetic Methodology for the Construction of 7-Substituted Farnesyl Diphosphate Analogs (2011)

Through the use of a 1,2-metalate rearrangement, six 7-substituted farnesol analogs were generated in a concise manner. This new synthetic route allowed us to quickly prepare several diverse farnesyl diphosphate analogs with interesting biological activities against mammalian protein-farnesyl transferase.
50 nm Pattern Etching of Si Wafer by Synchrotron Radiation Excited CF<sub> 4</sub> Plasma (1997)

50 nm lines and spaces pattern etching on a Si wafer in a synchrotron radiation (SR) excited CF 4 gas atmosphere was performed under a negative bias voltage in which the SR light beam was irradiated perpendicularly to the Si wafer. As etching species, positive ions are expected to be predominant. The SR excited plasma and the excited species are discussed.
THE INDUSTRY OVERVIEW (1994)

Interline Service Management (ISM) is a framework of carrier business processes tailored by each carrier. It is a reengineered business process for managing shipments from origin to destination. These business processes include marketing, customer service, equipment management, and the service and design of the transportation function of railroads. ISM also involves electronic data interchange. Finally, ISM is a central information system; and it also represents continuous improvement in the industry. This paper presents an overview of ISM in the railroad industry.
[Comparative study of the therapeutic effect of diets with qualitatively and quantitatively different fat content on children with cirrhosis of the liver]. (1977)

A total of 107 children with liver cirrhosis aged from 7 to 12 were kept under observation. Four types of diets with different variants of the fatty component were used in the course of their treatment. The diet No 5 ration contained a physiological set of basic nutrients (with vegetable oil comprising 12% of the total amount of fat in the ration). The diet 52 carried a higher amount of the vegetable oil with its proportion reaching 22% of the total quantity of fat at the expense of a lesser share of butter. The total amount of fat was consistent with the age-specific standard rate. The diets 53 and 54 has the amount of fat raised by 15% with respect to the physiological level through additional introduction of vegetable oil and butter "Zdorovie", respectively. The fat-enriched diets were well tolerated with no manifestations of steatorrhea in evidence. Against the background of all the diets applied the great majority of the patients demonstrated an improvement of both the clinical data (general conditions, reduction in the size of the liver) and a number of characteristics reflecting the functional capacity of the liver (normalization of the blood serum bilirubin, of proteinogram findings). Following the use of diets with an elevated fat content there could be observed a well-marked tendency toward normalization of metabolic rates. In particular the level of the blood serum cholesterol esthers was rising; the plasma and lipids of the erythrocytes stroma showed an increased proportion of arachidonic acid with simultaneous fall of the icosatrienic acid share. This may ascribed to a higher content of polyunsaturated fatty acids in the ration. The most convenient way of introducing polyunsaturated fatty acids in the ration is the dietetic butter "Zdorovie". This justifies recommending it in dietotherapy of children suffering from liver cirrhosis.
Clinical Features and Molecular Diagnosis of Chikungunya Fever from South India (2008)

An epidemic of Chikungunya fever of unprecedented magnitude occurred in many parts of India in early 2006 after an interval of 33 years, and there has been a resurgence in some parts of South India since June 2007. The article highlights clinical manifestations of infection and various molecular tests that were used for diagnoses of Chikungunya virus infection. Of particular interest is the real-time loop-mediated isothermal amplification (RT LAMP) assay, which is rapid and cost-effective and can be adopted at ill-equipped laboratories. Clinical symptoms were characterized by a triad of fever, rash, and severe rheumatic manifestations. RT LAMP identified 20 additional Chikungunya virus-positive cases, compared with reverse-transcriptase polymerase chain reaction. Chikungunya virus was isolated from 20 randomly selected samples. Genotyping of the virus isolates revealed that the East Central South African genotype of Chikungunya virus was the etiologic agent of this epidemic. Molecular diagnosis is an important tool to identify such new vectorborne viral illnesses.
Application of a Molecular Dynamics Simulation Method with a Generalized Effective Potential to the Flexible Molecular Docking Problems (1999)

We present a new molecular dynamics method using Tsallis effective potential for the flexible docking problems of streptavidin/biotin and protein kinase C/phorbol-13-acetate. With a full flexibility of the ligands and a partial flexibility of the receptor active sites included, the new MD scheme accelerates the docking process significantly, by way of infrequent q-jumping and q-relaxation procedures between a normal potential energy surface and its transformed one by the Tsallis scheme. In the transformation, only the nonbonding interaction terms of an empirical potential energy function were employed. It has been found that the current method can predict the correctly docked structures in quite an effective way. Current results strongly indicate that this new MD method can be a very promising strategy for flexible ligand/flexible receptor docking.
Improved droop control for parallel inverters in microgrids (2012)

In this paper, an improved droop control method is proposed for the parallel inverters in microgrids. The proposed strategy is based on the droop control technique, which only using the local measurable feedback information. This approach can be applied to the inverter-based microgrids where communication wires are not economic and reliable due to the distant physical locations. Unfortunately, the trade-off has to be made between the transient response and the power sharing accuracy for the conventional voltage and frequency droop control method. Moreover, the output and line impedance of the inverter presents a great impact on the power sharing accuracy. The proposed method takes into account the resistance of inverter output impedance and line impedance, and uses the active and reactive output current as the control variables, which limits the current spikes during the initial and transient states. Additionally, the derivate-integral terms are introduced to enhance the dynamic response of the inverters. Simulation results and experimental waveforms are given to validate the proposed control strategy.
RETRACTED: Death-receptor activation halts clathrin-dependent endocytosis (2006)

Endocytosis is crucial for various aspects of cell homeostasis. Here, we show that proapoptotic death receptors (DRs) trigger selective destruction of the clathrin-dependent endocytosis machinery. DR stimulation induced rapid, caspase-mediated cleavage of key clathrin-pathway components, halting cellular uptake of the classic cargo protein transferrin. DR-proximal initiator caspases cleaved the clathrin adaptor subunit AP2alpha between functionally distinct domains, whereas effector caspases processed clathrin's heavy chain. DR5 underwent ligand-induced, clathrin-mediated endocytosis, suggesting that internalization of DR signaling complexes facilitates clathrin-pathway targeting by caspases. An endocytosis-blocking, temperature-sensitive dynamin-1 mutant attenuated DR internalization, enhanced caspase stimulation downstream of DRs, and increased apoptosis. Thus, DR-triggered caspase activity disrupts clathrin-dependent endocytosis, leading to amplification of programmed cell death.
Preparation of Single Cell Suspensions from Mouse Aorta (2016)

Atherosclerosis is a chronic inflammatory disease of the arterial wall characterized by lipid deposition, plaque formation, and immune cell infiltration. Innate and adaptive immune cells infiltrate the artery during development of the disease. Moreover, advanced disease leads to formation of artery tertiary lymphoid organs in the adventitia (Grabner <i>et al</i>., 2009; Hu <i>et al</i>., 2015). Various and diverse types of immune cells have been identified in the aorta adventitia vs atherosclerotic plaques (Elewa <i>et al</i>., 2016; Galkina <i>et al</i>., 2006; Lotzer <i>et al</i>., 2010; Mohanta <i>et al</i>., 2016; Mohanta <i>et al</i>., 2014; Moos <i>et al</i>., 2005; Srikakulapu <i>et al</i>., 2016; Zhao <i>et al</i>., 2004). There are conflicting reports on the number and subtypes of immune cells in the aorta depending on the age of the animals, the protocol that is used to obtain single cell suspensions, and the dietary conditions of the mice (Campbell <i>et al</i>., 2012; Clement <i>et al</i>., 2015; Galkina <i>et al</i>., 2006; Kyaw <i>et al</i>., 2012). The number of immune cells in the aorta differs as much as tenfold using different protocols (Butcher <i>et al</i>., 2012; Galkina <i>et al</i>., 2006; Gjurich <i>et al</i>., 2015; Grabner <i>et al</i>., 2009; Hu <i>et al</i>., 2015). These discrepant results call for a protocol that robustly documents <i>bona fide</i> aorta cells rather than those in the surrounding tissues or blood. Critical methodological hurdles include the removal of adjacent adipose tissue and small paraaortic lymph nodes lining the entire aortic tree that are not visible by the naked eye. A dissection microscope is therefore recommended. Moreover protocols of aorta preparations should ascertain that lymphocyte aggregates referred to as <i>fat associated lymphoid clusters</i> (FALCs) (Benezech <i>et al</i>., 2015; Elewa <i>et al</i>., 2015) that are often present at the border between the adipose tissue and the adventitia are removed before enzyme digestion. We propose - besides other approaches (Hu <i>et al</i>., 2015; Mohanta <i>et al</i>., 2014) - a combination of immunohistochemical staining and fluorescence activated cell sorter (FACS) analyses from single cell suspensions to quantify the cells of interest. This protocol describes isolation of single cells from mouse aorta for FACS and other analysis.
Biomarker discovery in breast cancer serum using 2‐D differential gel electrophoresis/ MALDI‐TOF/TOF and data validation by routine clinical assays (2006)

In the present study, we used 2-D differential gel electrophoresis (2-D DIGE) and MS to screen biomarker candidates in serum samples obtained from 39 patients with breast cancer and 35 controls. First, we pooled the serum samples matched with age and menopausal status. Then, we depleted the two most abundant proteins albumin and IgG by immunoaffinity chromatography under partly denaturing conditions in order to enrich low-abundance proteins and proteins with low molecular weight. Concentrated and desalted samples were labeled with three different CyDyes including one internal standard, pooled from all the samples, and separated with 2-D DIGE in triplicate experiments. Biological variations of the protein expression level were analyzed with DeCyder software and evaluated for reproducibility and statistical significance. The profile of differentially expressed protein spots between patients and controls revealed proapolipoprotein A-I, transferrin, and hemoglobin as up-regulated and three spots, apolipoprotein A-I, apolipoprotein C-III, and haptoglobin alpha2 as down-regulated in patients. Finally, routine clinical immunochemical reactions were used to validate selected candidate biomarkers by quantitative determination of specific proteins in all individual serum samples. The serum level of transferrin correlated well with the 2-D-DIGE results. However, the serum levels of apolipoprotein A-I and haptoglobin could not be detected with the clinical routine diagnostic tests. This demonstrated an advantage 2-D DIGE still has over other techniques. 2-D DIGE can distinguish between isoforms of proteins, where the overall immunochemical quantification does fail due to a lack of isoform-special antibodies.
Alleviation of carbon catabolite repression in Enterobacter aerogenes for efficient utilization of sugarcane molasses for 2,3-butanediol production (2015)

We have developed genetically engineered E. aerogenes as a 2,3-butanediol producer that efficiently utilizes sugarcane molasses. The fermentation efficiency was dramatically improved by the alleviation of CCR and modulation of carbon preference. These results offer a metabolic engineering approach for achieving highly efficient utilization of mixed sugars for the biorefinery industry.
Surface Modification with Poly(sulfobetaine methacrylate-<i>co</i>-acrylic acid) To Reduce Fibrinogen Adsorption, Platelet Adhesion, and Plasma Coagulation (2011)

Zwitterionic sulfobetaine methacrylate (SBMA) polymers were known to possess excellent antifouling properties due to high hydration capacity and neutral charge surface. In this study, copolymers of SBMA and acrylic acid (AA) with a variety of compositions were synthesized and were immobilized onto polymeric substrates with layer-by-layer polyelectrolyte films via electrostatic interaction. The amounts of platelet adhesion and fibrinogen adsorption were determined to evaluate hemocompatibility of poly(SBMA-co-AA)-modified substrates. Among various deposition conditions by modulating SBMA ratio in the copolymers and pH of the deposition solution, poly(SBMA(56)-co-AA(44)) deposited at pH 3.0 possessed the best hemocompatibility. This work demonstrated that poly(SBMA-co-AA) copolymers adsorbed on polyelectrolyte-base films via electrostatic interaction improve hemocompatibility effectively and are applicable for various substrates including TCPS, PU, and PDMS. Furthermore, poly(SBMA-co-AA)-coated substrate possesses great durability under rigorous conditions. The preliminary hemocompatibility tests regarding platelet adhesion, fibrinogen adsorption, and plasma coagulation suggest the potential of this technique for the application to blood-contacting biomedical devices.
A depressive endophenotype of poorer cognition among cognitively healthy community‐dwelling adults: results from the Western Australia memory study (2014)

Elevated DepE scores are associated with poor neuropsychological performance among cognitively normal older adults. Use of the DepE may allow for the identification of a subset of older adults where depression is a primary factor in cognitive decline and who may benefit from antidepressant therapies.
Distribution of Nitrogen and Nickel in a Synthetic Diamond Crystal Observed with Scanning ESR Imaging (1990)

The spatial distribution of single substitutional nitrogen and nickel in a synthetic diamond crystal has been imaged with a microwave scanning ESR imaging method. The growth sectorial dependence of the concentration and the linewidth of nitrogen and nickel centers was observed with the resolution of 0.5 mm. The Ni-rich region was seen only at some parts of the (111) sectors while nitrogen was rich in the entire (111) sectors. The linewidth of the nitrogen signal qualitatively correlates with the concentration of nickel.
Robust Transceiver Optimization in Downlink Multiuser MIMO Systems (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We study robust transceiver optimization in a downlink, multiuser, wireless system, where the transmitter and the receivers are equipped with antenna arrays. The robustness is defined with respect to imperfect knowledge of the channel at the transmitter. The errors in the channel state information are assumed to be bounded, and certain quality-of-service targets in terms of mean-square errors (MSEs) are guaranteed for all channels from the uncertainty regions. Iterative algorithms are proposed for the transceiver design. The iterations perform alternating optimization of the transmitter and the receivers and have equivalent semidefinite programming representations with efficient numerical solutions. The framework supports robust counterparts of several MSE-optimization problems, including transmit power minimization with per-user or per-stream MSE constraints, sum MSE minimization, min-max fairness, etc. Although the convergence to the global optimum cannot be claimed due to the intricacy of the problems, numerical examples show good practical performance of the presented methods. We also provide various possibilities for extensions in order to accommodate a broader set of scenarios regarding the precoder structure, the uncertainty modeling, and a multicellular setup. </para>
ATM cell transmission over the IEEE 802.11 wireless MAC protocol (2002)

The growing acceptance of the ATM as the transfer mechanism of the future B-ISDN, the increasing user requirements for portability and mobility and the increasing power of the portable devices, have led many researchers to investigate the transmission of ATM cells over a wireless medium. This paper discusses the necessary extensions to the B-ISDN protocol reference model, in order to support mobile applications. Finally, the IEEE 802.11 MAC layer protocol and its ability to transport ATM cells, preserving the delay requirements of the delay-sensitive applications, are investigated.
Vapor−Liquid Equilibrium and Excess Enthalpy Data for the Binary Systems Propane + Dimethyl Ether and Propene + Dimethyl Ether at Temperatures from (298 to 323) K (2003)

Isothermal vapor−liquid equilibrium (VLE) data for the binary systems propane + dimethyl ether and propene + dimethyl ether were determined experimentally with the static synthetic and the static analytic methods. Additionally, excess enthalpy (HE) data were determined by means of an isothermal flow calorimeter. For the system propane + dimethyl ether, the azeotropic compositions were derived graphically from the VLE data. The experimental data from this work were correlated by using a linear temperature dependence for the UNIQUAC interaction parameters and by treating the real vapor phase behavior with the Soave−Redlich−Kwong equation of state. On the basis of this correlation, the new data were compared to values taken from the literature.