gebhart/patrepeval huggingface dataset:
Exergaming for balance training of elderly: state of the art and future developments (2013)

Fall injuries are responsible for physical dysfunction, significant disability, and loss of independence among elderly. Poor postural control is one of the major risk factors for falling but can be trained in fall prevention programs. These however suffer from low therapy adherence, particularly if prevention is the goal. To provide a fun and motivating training environment for elderly, exercise games, or exergames, have been studied as balance training tools in the past years. The present paper reviews the effects of exergame training programs on postural control of elderly reported so far. Additionally we aim to provide an in-depth discussion of technologies and outcome measures utilized in exergame studies. Thirteen papers were included in the analysis. Most of the reviewed studies reported positive results with respect to improvements in balance ability after a training period, yet few reached significant levels. Outcome measures for quantification of postural control are under continuous dispute and no gold standard is present. Clinical measures used in the studies reviewed are well validated yet only give a global indication of balance ability. Instrumented measures were unable to detect small changes in balance ability as they are mainly based on calculating summary statistics, thereby ignoring the time-varying structure of the signals. Both methods only allow for measuring balance after the exergame intervention program. Current developments in sensor technology allow for accurate registration of movements and rapid analysis of signals. We propose to quantify the time-varying structure of postural control during gameplay using low-cost sensor systems. Continuous monitoring of balance ability leaves the user unaware of the measurements and allows for generating user-specific exergame training programs and feedback, both during one game and in timeframes of weeks or months. This approach is unique and unlocks the as of yet untapped potential of exergames as balance training tools for community dwelling elderly.
Intelligent real-time control of robotic vehicles (1991)

article Free Access Share on Intelligent real-time control of robotic vehicles Authors: David W. Payton Hughes Research Labs, Malibu, CA Hughes Research Labs, Malibu, CAView Profile , Thomas E. Bihari Adaptive Machine Technologies, Columbus, OH Adaptive Machine Technologies, Columbus, OHView Profile Authors Info & Claims Communications of the ACMVolume 34Issue 8Aug. 1991 pp 49–63https://doi.org/10.1145/108515.108527Published:01 August 1991Publication History 27citation1,019DownloadsMetricsTotal Citations27Total Downloads1,019Last 12 Months7Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
DVD copy protection: take 2 (2005)

This paper describes the advanced access content systems (AACS), the copy protection scheme designed to keep future generations safe from pirated DVDs. The ACCS group was founded by IBM, Intel, Microsoft, Panasonic, Sony, Toshiba, Disney, and Warner Bros. Studios. The AACS specification allow customers to move the data on an optical disc to various devices they own, including video servers and portable video players, either directly or via a home network. In all the scenarios developed by the AACS alliance, that data would exist on the disc in encrypted form. It would stay encrypted when transferred to other devices and would be decrypted by those devices. ACCS used a so-called strong key, the 128-bit Advanced Encryption Standards that has the ability to keep on protecting data even after it has been cracked.
Catalase−Peroxidase Activity of Iron(III)−TAML Activators of Hydrogen Peroxide (2008)

Exceptionally high peroxidase-like and catalase-like activities of iron(III)-TAML activators of H 2O 2 ( 1: Tetra-Amidato-Macrocyclic-Ligand Fe (III) complexes [ F e{1,2-X 2C 6H 2-4,5-( NCOCMe 2 NCO) 2CR 2}(OH 2)] (-)) are reported from pH 6-12.4 and 25-45 degrees C. Oxidation of the cyclometalated 2-phenylpyridine organometallic complex, [Ru (II)( o-C 6H 4py)(phen) 2]PF 6 ( 2) or "ruthenium dye", occurs via the equation [ Ru II ] + 1/2 H 2 O 2 + H +-->(Fe III - TAML) [ Ru III ] + H 2 O, following a simple rate law rate = k obs (per)[ 1][H 2O 2], that is, the rate is independent of the concentration of 2 at all pHs and temperatures studied. The kinetics of the catalase-like activity (H 2 O 2 -->(Fe III - TAML) H 2 O + 1/2 O 2) obeys a similar rate law: rate = k obs (cat)[ 1][H 2O 2]). The rate constants, k obs (per) and k obs (cat), are strongly and similarly pH dependent, with a maximum around pH 10. Both bell-shaped pH profiles are quantitatively accounted for in terms of a common mechanism based on the known speciation of 1 and H 2O 2 in this pH range. Complexes 1 exist as axial diaqua species [FeL(H 2O) 2] (-) ( 1 aqua) which are deprotonated to afford [FeL(OH)(H 2O)] (2-) ( 1 OH) at pH 9-10. The pathways 1 aqua + H 2O 2 ( k 1), 1 OH + H 2O 2 ( k 2), and 1 OH + HO 2 (-) ( k 4) afford one or more oxidized Fe-TAML species that further rapidly oxidize the dye (peroxidase-like activity) or a second H 2O 2 molecule (catalase-like activity). This mechanism is supported by the observations that (i) the catalase-like activity of 1 is controllably retarded by addition of reducing agents into solution and (ii) second order kinetics in H 2O 2 has been observed when the rate of O 2 evolution was monitored in the presence of added reducing agents. The performances of the 1 complexes in catalyzing H 2O 2 oxidations are shown to compare favorably with the peroxidases further establishing Fe (III)-TAML activators as miniaturized enzyme replicas with the potential to greatly expand the technological utility of hydrogen peroxide.
Preparation and characterization of crosslinked gelatin microspheres (1995)

Abstract Gelatin, a natural macromolecule, is widely used in biomedical and biotechnological applications and is a good candidate for preparation of microspheres and microcapsules for the purpose of controlled release applications of drugs. In this study, gelatin microspheres crosslinked with glutaraldehyde with different crosslink densities were prepared by the phase separation technique induced by temperature change. The chemical structures of the microspheres were examined with FTIR and formation of crosslinks were observed. Topography, size, and shape of the microspheres were examined with scanning electron microscopy (SEM) and a narrow size distribution (approximately 1 μm) was observed. Thermal properties of microspheres were analyzed by differential scanning calorimetry and an increase in glass transition temperature values with an increase in crosslinking was observed. For each sample, dry and swollen densities of microspheres were determined by pycnometric methods and the average molecular weights between the crosslinks, M c , were calculated from the equilibrium swelling experiments using the modified Flory‐Rehner thermodynamic theory. A decrease in percent solvent content values with decreasing average molecular weight between the crosslinks was observed. © 1995 John Wiley & Sons, Inc.
Spectroscopic Ellipsometry Measurement and Modeling of Hydrogenated Amorphous Silicon (2019)

Spectroscopic ellipsometry is a powerful tool for analyzing optical properties of material. Ellipsometry measurement results is usually given by change of polarization state of probe light, so the measured result should be properly treated and transformed to meaningful parameters by transformation and modeling of the measurement result. In case of hydrogenated amorphous silicon, Tauc-Lorentz dispersion is usually used to model the measured ellipsometry spectrum. In this paper, modeling of spectroscopic ellipsometry result of hydrogenated amorphous silicon using Tauc-Lorentz dispersion is discussed.
The Role of Lysophosphatidic Acid on Airway Epithelial Cell Denudation in a Murine Heterotopic Tracheal Transplant Model (2015)

The LPA signaling is involved in the status of epithelial cells by distinct contribution in 2 different phases of the OB lesion. This finding suggests a role of LPA in the pathogenesis of OB.
Novel reactions of carbon suboxide. Synthesis of 1,5‐benzodioxepins, 1,5‐benzoxathiepins and 1,5‐benzoxazepins (1982)

Abstract The preparation of 1,5‐benzodioxepins, 1,5‐benzoxathiepins and 1,5‐benzoxazepins derivatives is described here. The structure of the products has been determined by elemental analysis and spectroscopic data.
Electrochemical detection of single micelles through ‘nano-impacts’ (2015)

A new class of 'soft' particles, micelles, is detected electrochemically <i>via</i> 'nano-impacts' for the first time. Short, sharp bursts of current are used to indicate the electrical contact of a single CTAB (cetyltrimethylammonium bromide) micelle with an electrode <i>via</i> the oxidation of the bromide content. The variation in CTAB concentration for such 'nano-impact' experiments shows that a significant number of 'spikes' are observed above the CMC (critical micelle concentration) and this is attributed to the formation of micelles. A comparison with dynamic light scattering is also reported.
Theory of vibratory mobilization on nonwetting fluids entrapped in pore constrictions (2006)

Abstract Quantitative dynamics of a nonwetting ganglion of residual oil entrapped in a pore constriction and subjected to vibrations of the pore wall can be approximated by the equation of motion of an oscillator moving under the effect of the external pressure gradient, inertial oscillatory force, and restoring capillary force. The solution of the equation provides the conditions under which the droplet experiences forced oscillations without being mobilized or is liberated from its entrapped configuration if the acceleration of the wall exceeds an unplugging value. This solution provides a quantitative tool for estimating the parameters of vibratory fields needed to liberate entrapped, nonwetting fluids. For typical pore sizes encountered in reservoir rock, wall accelerations must exceed at least several m∕s2 and even much higher levels to mobilize the droplets of oil; however, in the populations of ganglia entrapped in natural porous environments, many may reside very near their mobilization thresholds and may be mobilized by extremely low accelerations as well. For given acceleration, lower seismic frequencies are more efficient in liberating the ganglia.
Multi-path Probabilistic Available Bandwidth Estimation through Bayesian Active Learning (2010)

Knowing the largest rate at which data can be sent on an end-to-end path such that the egress rate is equal to the ingress rate with high probability can be very practical when choosing transmission rates in video streaming or selecting peers in peer-to-peer applications. We introduce probabilistic available bandwidth, which is defined in terms of ingress rates and egress rates of traffic on a path, rather than in terms of capacity and utilization of the constituent links of the path like the standard available bandwidth metric. In this paper, we describe a distributed algorithm, based on a probabilistic graphical model and Bayesian active learning, for simultaneously estimating the probabilistic available bandwidth of multiple paths through a network. Our procedure exploits the fact that each packet train provides information not only about the path it traverses, but also about any path that shares a link with the monitored path. Simulations and PlanetLab experiments indicate that this process can dramatically reduce the number of probes required to generate accurate estimates.
Control of brown rot and shot hole in almond: 2009 field trial (2010)

We conducted a field trial to evaluate the efficacy of a synthetic fungicide (Pristine; boscalid and pyraclostrobin) and two organic fungicides (Regalia; extract of Reynoutria sachilinensis and JMS Stylet-oil; paraffinic oil) for management of two foliar diseases in almond. Pristine and Pristine alternated with Regalia effectively reduced symptoms of both brown rot and shot hole following three applications from red bud to post-bloom. JMS Stylet-oil and Regalia alone did not control the diseases.
Direct Expression of Adrenodoxin Reductase in Escherchia coli and the Functional Characterization. (1993)

A plasmid for direct expression in Escherichia coli of the mature form bovine adrenodoxin reductase was constructed from the full-size cDNA for the enzyme [Y. Sagara, Y. Takata, T. Miyata, T. Hara, and T. Horiuchi, J. Biochem. (Tokyo), 102, 1333 (1987)] and an expression vector pCWori+. The recombinant adrenodoxin reductase was purified from the transformed E. coli cell lysates using adrenodoxin-Sepharose affinity chromatography [T. Sugiyama and T. Yamano, FEBS Lett., 52, 145 (1975)] with a yield of 2.5 mg/l of culture. The purified recombinant enzyme showed a single band on polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and migration was identical with that of the authentic enzyme purified from bovine adrenal cortex mitochondria. The recombinant enzyme had Ser at its amino-terminus and the sequence of the amino terminal 9 residues was identical with that of the authentic bovine enzyme. The absorption spectrum of the recombinant enzyme showed peaks at 270, 376, and 450 nm and shoulders at 425 and 475 nm. Flavin content of the recombinant enzyme was 0.8 mol FAD/mol. The apparent Km value for bovine adrenodoxin in NADPH-cytochrome c reductase activity using a reconstitution system was 16 nM, a value comparable with that of the authentic bovine enzyme (17 nM). The cholesterol side chain cleavage activity with a reconstitution system was about 75% of that obtained when the authentic enzyme was used.
Patient information (1999)

Producing information for patients has become an increasing part of the medical illustrator's workload. This article looks at the benefits of providing patients with information, against the background of political history, legal requirements and the element of design. It concludes with recommendations for improving the quality of patient information.
Visualizing dynamic software system information through high-level models (1998)

Dynamic information collected as a software system executes can help software engineers perform some tasks on a system more effectively. To interpret the sizable amount of data generated from a system's execution, engineers require tool support. We have developed an off-line, flexible approach for visualizing the operation of an object-oriented system at the architectural level. This approach complements and extends existing profiling and visualization approaches available to engineers attempting to utilize dynamic information. In this paper, we describe the technique and discuss preliminary qualitative studies into its usefulness and usability. These studies were undertaken in the context of performance tuning tasks.
Feuchtemessung an Stuckkoks mit Neutronen (1967)

Das auf der Bremsung schneller Neutronen durch leichte Atomkerne basierende Verfahren zur Feuchtebestimmung wurde an Stückkoks erprobt. Durch Laborversuche wurde die prinzipielle Eignung dieser Methode festgestellt. Anschlieβende praktische Messungen im Betrieb zeigten, daβ im Bereich zwischen 0 und 20% Wasser die Feuchtigkeit von Stückkoks mit einer Genauigkeit von ± 0,6 bis ± 0,9% Wasser bestimmt werden kann. Damit ist es möglich, die bisher angewandte und unzulängliche manuelle Koksfeuchtemessung durch das kontinuierlich arbeitende Neutronenverfahren zu ersetzen.
Isolation and characterization of Neurospora crassa plasma membranes. (1975)

The isolation and characterization of plasma membranes from a cell wall-less mutant of Neurospora crassa are described. The plasma membranes are stabilized against fragmentation and vesiculation by treatment of intact cells with concanavalin A just prior to lysis. After lysis, the concanavalin A-stabilized plasma membrane ghosts are isolated by low speed centrifugation techniques and the purified ghosts subsequently converted to vesicles by removal of the bulk of the concanavalin A. The yield of ghosts is about 50% whereas the yield of vesicles is about 20%. The isolated plasma membrane vesicles have a characteristically high sterol to phospholipid ratio, Mg2+-dependent ATPase activity and (Na+ plus K+)-stimulated Mg2+ATPase activity. Only traces of succinate dehydrogenase and 5'-nucleotidase are present in the plasma membrane preparations.
A new approach to construct three dimensional segregated graphene structures in rubber composites for enhanced conductive, mechanical and barrier properties (2016)

A novel pre-construction method was reported for the first time to fabricate conductive rubber composites with a conductive 3D-graphene segregated network.
From the Superhuman to the Human in <i>Paradise Lost</i> (1933)

One of the greatest beauties of Paradise Lost lies, I think, in the gradual transition from the supernatural to the natural, in the felicitous approach and descent to the close. I have elsewhere shown the twilight scene at the last, with its pensive mood and rhythm, the exiled pair looking forward but also backward, going hand in hand but with wandering steps and slow, to be appropriate not only to the situation—this end of Paradise and beginning of life—but to the rest of the poem. I there pointed out a few of the many preparations for such a quiet and consolatory ending in the avowed purpose of God to bring good out of evil, make death not only a penalty but a remedy, and dismiss our first parents, though sorrowing, yet in peace.
CD30 expression does not discriminate between human Th1- and Th2-type T cells (1996)

CD30 is a member of the TNF receptor superfamily that is commonly used as a marker for Hodgkin and Reed-Sternberg cells in Hodgkin's disease. More recently, it has been proposed that CD30 is preferentially up-regulated on Th2-type human T cells. We analyzed regulation of CD30 expression on both peripheral blood T cells and T cell clones. In short-term culture, CD30 expression could be induced on T cells by Ags that elicit Th2-type responses (Schistosoma haematobium, adult worm Ag, and Toxocaria canis, excretory/secretory Ag) and Th0-type responses (tetanus toxoid), as well as Th1-type responses (tuberculin purified protein derivative). Moreover, simultaneous measurement of membrane phenotype and cytokine production showed that CD30-expressing cells can produce IFN-gamma. Finally, within panels of randomly generated as well as Ag-specific T cell clones, CD30 expression was found on Th0-, Th2-, and Th1-type clones. We conclude that induction of CD30 on activated T cells is not related to differentiation in Th0-, Th1-, or Th2-type cells.
A robust lane detection and departure warning system (2015)

In this work, we have developed a robust lane detection and departure warning technique. Our system is based on single camera sensor. For lane detection a modified Inverse Perspective Mapping using only a few extrinsic camera parameters and illuminant Invariant techniques is used. Lane markings are represented using a combination of 2nd and 4th order steerable filters, robust to shadowing. Effect of shadowing and extra sun light are removed using Lab color space, and illuminant invariant representation. Lanes are assumed to be cubic curves and fitted using robust RANSAC. This method can reliably detect lanes of the road and its boundary. This method has been experimented in Indian road conditions under different challenging situations and the result obtained were very good. For lane departure angle an optical flow based method were used.
DSG2 Is a Functional Cell Surface Marker for Identification and Isolation of Human Pluripotent Stem Cells (2018)

Pluripotent stem cells (PSCs) represent the most promising clinical source for regenerative medicine. However, given the cellular heterogeneity within cultivation and safety concerns, the development of specific and efficient tools to isolate a pure population and eliminate all residual undifferentiated PSCs from differentiated derivatives is a prerequisite for clinical applications. In this study, we raised a monoclonal antibody and identified its target antigen as desmoglein-2 (DSG2). DSG2 co-localized with human PSC (hPSC)-specific cell surface markers, and its expression was rapidly downregulated upon differentiation. The depletion of DSG2 markedly decreased hPSC proliferation and pluripotency marker expression. In addition, DSG2-negative population in hPSCs exhibited a notable suppression in embryonic body and teratoma formation. The actions of DSG2 in regulating the self-renewal and pluripotency of hPSCs were predominantly exerted through the regulation of β-catenin/Slug-mediated epithelial-to-mesenchymal transition. Our results demonstrate that DSG2 is a valuable PSC surface marker that is essential for the maintenance of PSC self-renewal.
Topic maps in E-learning: An Ontology Ensuring an Active Student Role as Producer (2006)

Abstract: Topic maps have been introduced as a HCI-solution within e-learning. One problem when using topic maps is that the student is left in a passive consumer role. The article proposes a topic map ontology, focusing on both students and teachers as active producers of learning resources. The article also discusses how small-scale and large-scale sharing of student-made learning resources can be achieved. Topic maps customize the interface, and the interface should also provide possibilities for online students to share learning resources like “on campus ” students do. The article also discusses implications for the online teacher’s role and how students could be encouraged to share in an online learning environment.
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases (2016)

Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2) protein, comprise the predominant genetic cause of Parkinson's disease (PD). G2019S, the most common amino acid substitution activates the kinase two- to threefold. This has motivated the development of LRRK2 kinase inhibitors; however, poor consensus on physiological LRRK2 substrates has hampered clinical development of such therapeutics. We employ a combination of phosphoproteomics, genetics, and pharmacology to unambiguously identify a subset of Rab GTPases as key LRRK2 substrates. LRRK2 directly phosphorylates these both in vivo and in vitro on an evolutionary conserved residue in the switch II domain. Pathogenic LRRK2 variants mapping to different functional domains increase phosphorylation of Rabs and this strongly decreases their affinity to regulatory proteins including Rab GDP dissociation inhibitors (GDIs). Our findings uncover a key class of bona-fide LRRK2 substrates and a novel regulatory mechanism of Rabs that connects them to PD.
Marker-assisted selection: an approach for precision plant breeding in the twenty-first century (2007)

DNA markers have enormous potential to improve the efficiency and precision of conventional plant breeding via marker-assisted selection (MAS). The large number of quantitative trait loci (QTLs) mapping studies for diverse crops species have provided an abundance of DNA marker-trait associations. In this review, we present an overview of the advantages of MAS and its most widely used applications in plant breeding, providing examples from cereal crops. We also consider reasons why MAS has had only a small impact on plant breeding so far and suggest ways in which the potential of MAS can be realized. Finally, we discuss reasons why the greater adoption of MAS in the future is inevitable, although the extent of its use will depend on available resources, especially for orphan crops, and may be delayed in less-developed countries. Achieving a substantial impact on crop improvement by MAS represents the great challenge for agricultural scientists in the next few decades.