gebhart/patrepeval huggingface dataset:
Advances in the science and treatment of alcohol use disorder (2019)

Alcohol is a major contributor to global disease and a leading cause of preventable death, causing approximately 88,000 deaths annually in the United States alone. Alcohol use disorder is one of the most common psychiatric disorders, with nearly one-third of U.S. adults experiencing alcohol use disorder at some point during their lives. Alcohol use disorder also has economic consequences, costing the United States at least $249 billion annually. Current pharmaceutical and behavioral treatments may assist patients in reducing alcohol use or facilitating alcohol abstinence. Although recent research has expanded understanding of alcohol use disorder, more research is needed to identify the neurobiological, genetic and epigenetic, psychological, social, and environmental factors most critical in the etiology and treatment of this disease. Implementation of this knowledge in clinical practice and training of health care providers is also needed to ensure appropriate diagnosis and treatment of individuals suffering from alcohol use disorder.
A Multi-Channel MAC Protocol for Wireless Sensor Networks (2006)

In this paper, we propose a novel multi-channel medium access control protocol for wireless sensor networks. Our protocol can dynamically assign multiple channels to nodes, thereby significantly increasing network energy efficiency, network lifetime and data throughput as well. The protocol requires only one transceiver per node, but solves the multi-channel hidden terminal problem through distributed coordinator node. Finally we evaluate the performance of this protocol through simulations. The performance results show that protocol significantly increase network energy efficiency, network lifetime and data throughput and exhibits prominent ability to utilize multi-channel transceiver among neighboring nodes.
Variants of Mersenne Twister Suitable for Graphic Processors (2010)

This paper proposes a type of pseudorandom number generator, Mersenne Twister for Graphic Processor (MTGP), for efficient generation on graphic processessing units (GPUs). MTGP supports large state sizes such as 11213 bits, and uses the high parallelism of GPUs in computing many steps of the recursion in parallel. The second proposal is a parameter-set generator for MTGP, named MTGP Dynamic Creator (MTGPDC). MT- GPDC creates up to 2^32 distinct parameter sets which generate sequences with high-dimensional uniformity. This facility is suitable for a large grid of GPUs where each GPU requires separate random number streams. MTGP is based on linear recursion over the two-element field, and has better high-dimensional equidistribution than the Mersenne Twister pseudorandom number generator.
Raman Spectra of Poly(2,3-R,R-thieno[3,4-b]pyrazine). A New Low-Band-Gap Polymer (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRaman Spectra of Poly(2,3-R,R-thieno[3,4-b]pyrazine). A New Low-Band-Gap PolymerJ. Kastner, H. Kuzmany, D. Vegh, M. Landl, L. Cuff, and M. KerteszCite this: Macromolecules 1995, 28, 8, 2922–2929Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/ma00112a044https://doi.org/10.1021/ma00112a044research-articleACS PublicationsRequest reuse permissionsArticle Views307Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spectral Pattern Classification in Lidar Data for Rock Identification in Outcrops (2014)

The present study aimed to develop and implement a method for detection and classification of spectral signatures in point clouds obtained from terrestrial laser scanner in order to identify the presence of different rocks in outcrops and to generate a digital outcrop model. To achieve this objective, a software based on cluster analysis was created, named K-Clouds. This software was developed through a partnership between UNISINOS and the company V3D. This tool was designed to begin with an analysis and interpretation of a histogram from a point cloud of the outcrop and subsequently indication of a number of classes provided by the user, to process the intensity return values. This classified information can then be interpreted by geologists, to provide a better understanding and identification from the existing rocks in the outcrop. Beyond the detection of different rocks, this work was able to detect small changes in the physical-chemical characteristics of the rocks, as they were caused by weathering or compositional changes.
MAPPING OF THE T-CELL AND B-CELL EPITOPES OF THE MYCOBACTERIUM-BOVIS PROTEIN, MPB70 (1990)

A clone coding for the entire gene for the Mycobacterium bovis protein antigen MPB70 was used to produce a series of overlapping subclones by making a series of deletions from the 3' end of the gene. The subclones expressed incomplete MPB70 proteins as fusions with glutathione-S-transferase. The insert DNA was sequenced to determine the extent of the deletion and the proteins expressed by the clones were examined for the presence of T cell and B cell epitopes. T cell epitopes were mapped by measuring the ability of recombinant antigens to stimulate gamma interferon (gamma-IFN) production in a whole blood culture system. gamma-IFN production was measured using a sandwich enzyme immunoassay specific for bovine gamma-IFN. B cell epitopes were mapped with a series of anti-MPB70 monoclonal antibodies using an indirect enzyme immunoassay.
Fluorimetric determination of iron using 5-(4-methoxyphenylazo)-8-(4-toluenesulfonamido)quinoline (2000)

A highly sensitive and relatively interference-free fluorimetric method for the determination of iron(III) is described. The method is based on the reaction between iron(III) and 5-(4-methoxyphenylazo)-8- (4-toluenesulfonamido)quinoline in the presence of cetyltrimethylammonium bromide. The fluorescence intensity (λex = 317 nm, λem = 534 nm) is linear up to 3 μM (170 ng ml−1) iron(III) in aqueous solution with a repeatability (RSD) of 3.2% at a concentration of 180 nM (10 ng ml−1) and a detection limit (3s) of 2 nM (0.12 ng ml−1). The influence of reaction variables and the effect of interfering ions are reported. The proposed procedure was applied to the determination of trace amounts of iron(III) and total iron in tap water, canal water and wine samples without the need for preconcentration, pre-separation or organic solvent extraction.
Protecting Abused Children: Helping Until it Hurts (1982)

The writer argues that the adoption of systematic methods of service delivery can lead to the failure of child welfare rather than to its success. He says that formulating rules for the response to abuse has caused the protective institutions to harm children bccause these rules break down informal helping systems.
Stable high-order delta-sigma DACS (2003)

Stability analysis of high-order delta-sigma loops is a challenge. In this work, a novel design criterion is presented for high-order multibit error-feedback DACs which are especially suitable for high-speed operation. This criterion allows the design of stable, robust, and high-resolution delta-sigma DACs. Both analytical and numerical analysis are performed for verification.
Diethyl carbonate as a solvent for ruthenium catalysed C–H bond functionalisation (2009)

The ruthenium catalysed direct functionalisation of arene C–H bonds by aryl halides is reported. Reactions were performed in diethyl carbonate (DEC) instead of N-methylpyrrolidone (NMP), the solvent of choice used in most ruthenium catalysed C–H bond transformations. The use of diethyl carbonate facilitates the workup procedure thus reducing the amount of waste water. The slight loss of activity due to the use of diethyl carbonate is counterbalanced by the improvement of the catalyst efficiency achieved by a judicious choice of additives. Several arenes containing an N-heterocycle as a directing group have been diarylated.
Tissue Harvester with Functional Valve (THFV): Shidham's device for reproducibly higher specimen yield by fine needle aspiration biopsy with easy to perform steps (2007)

The specimen yield with the new THFV was significantly higher when compared to hypodermic needles. Also, the FNAB procedure with THFV was relatively easier in comparison with hypodermic needles. The final version of Shidham's THFV device would improve the FNAB specimen yield by eliminating the skill factor. The increased specimen yield by this device would also facilitate wider application of FNAB specimens for various ancillary tests, including molecular tests.
A conical laser light-sectioning method for navigation of Autonomous Underwater Vehicles for internal inspection of pipelines (2009)

This paper presents a novel sensing method for navigation of autonomous underwater vehicles, AUVs, through pipelines to conduct autonomous internal inspection. Unlike remotely operated pipe inspection robots, AUVs do not have an umbilical cable and so they can easily maneuver through bent sections of pipelines and the distance they can cover is not restricted by the length of the cable. Presently pipe inspection robots come in contact with the walls of the pipe during their operation. However old and aged pipelines may have loose corroded materials or biological growth which may get detached and pollute the fluid or further damage pipe interior when the pipe inspections robots touch the walls. AUVs can operate without coming in contact with the pipe wall and so this technique is a non-contact measurement and inspection technique. The proposed navigation sensor makes use of computer vision techniques to estimate the relative position and orientation of the vehicle inside the pipe with 4 degrees of freedom, which will enable the AUV to swim through the center of the pipe. A conical laser is projected on the pipe wall and the image of the laser is acquired by a camera. The features of the image are extracted and matched with a feature database prepared apriori. The position and orientation of the matching feature record in the database gives the estimated position and orientation of the vehicle. Experiments were conducted in dry experimental pipelines to verify the performance of the proposed sensor and results are presented. Control simulations were performed to verify the ability of the sensor to navigate an AUV. The results of these controls simulated are also presented in this paper.
Bioactivities of black cumin essential oil and its main terpenes from Tunisia (2009)

Ex vivo antioxidant, anti-inflammatory, anticancer and antibacterial activities of the essential oil from Tunisian Nigella sativa seeds and its main terpenes (p-cymene, γ-terpinene, thymoquinone, β-pinene, carvacrol, terpinen-4-ol and longifolene) were determined. The essential oil exhibited strong ex vivo antioxidant activity, inhibiting DCFH oxidation with an IC50 of 1.0 µg/ml, and high anti-inflammatory activity, inhibiting NO radical excretion with an IC50 value of 6.3 µg/ml. Thymoquinone was found to be the most active to decrease DCFH oxidation and NO excretion. The oil was found to significantly inhibit the growth of A-549 and DLD-1 cancer cell lines (IC50 values of 43.0 and 46.0 µg/ml, respectively) and to exert antibacterial activity against Staphylococcus aureus and Escherichia coli with IC50 values of 12.0 and 62.0 µg/ml. The anticancer and antibacterial activities could be mainly due to the action of thymoquinone and longifolene.
Applications of High‐Nitrogen Energetics in Pyrotechnics: Development of Perchlorate‐Free Red Star M126A1 Hand‐Held Signal Formulations with Superior Luminous Intensities and Burn Times (2011)

Abstract Perchlorate‐free hand‐held signal illuminant formulations for the M126A1 red star parachute have been developed. The formulations exhibited longer burn times and higher luminous intensities compared to the US Army in‐service M126A1 formulation. The perchlorate‐free formulations derive their enhanced performance from the inclusion of strontium bis ‐(1‐methyl‐5‐nitriminotetrazolate) monohydrate, the choice of magnesium used, and replacing a polyester binder system with an epoxy binder system.
New Filter Technology in Picture Processing (1982)

In this paper we describe a new filtering technique for processing video signals called the "LOGICAL FILTER". With the Logical Filter, video signals in the time domain are assumed to be a set of "patterns" and the pattern recognition logic is applied to the filtering of the video signals.
High-dose Corticotropin (ACTH) Versus Prednisone for Infantile Spasms: A Prospective, Randomized, Blinded Study (1996)

Using a prospective, randomized approach, a 2-week course of high-dose ACTH is superior to 2 weeks of prednsone for treatment of IS, as assessed by both clinical and EEG criteria.
Dynamics of a high-power aluminum-wire array Z-pinch implosion (1997)

Annular Al-wire Z-pinch implosions on the Saturn accelerator [D. D. Bloomquist et al., Proceedings, 6th Pulsed Power Conference (Institute of Electrical and Electronics Engineers, New York, 1987), p. 310] that have high azimuthal symmetry exhibit both a strong first and weaker second x-ray burst that correlate with strong and weaker radial compressions, respectively. Measurements suggest that the observed magnetic Rayleigh–Taylor (RT) instability prior to the first compression seeds an m=0 instability observed later. Analyses of axially averaged spectral data imply that, during the first compression, the plasma is composed of a hot core surrounded by a cooler plasma halo. Two-dimensional (2-D) radiation magnetohydrodynamic computer simulations show that a RT instability grows to the classic bubble and spike structure during the course of the implosion. The main radiation pulse begins when the bubble reaches the axis and ends when the spike finishes stagnating on axis and the first compression ends. These simulations agree qualitatively with the measured characteristics of the first x-ray pulse and the overall energetics, and they provide a 2-D view into the plasma hydrodynamics of the implosion.
Surface Energy of North American Shales and its Role in Interaction of Shale with Surfactants and Microemulsions (2011)

Abstract In recent years a number of laboratory studies on the use of surfactants and microemulsions in hydraulic fracturing of shale formations have been reported. These studies mainly focused on such metrics as improvement in permeability regain and enhancement of fluid recovery from packed columns upon the use of surfactant-containing chemicals. Laboratory studies have also been backed by the documented observations from the field illustrating benefits of using microemulsions for the increase in gas production from shale formations. It is a commonly accepted view that these additives benefit gas production by lowering capillary pressure and altering wetability of shale formation. Although it is recognized that the interaction of surfactants and microemulsions with shale is governed by the energetics of solid/liquid, liquid/gas and solid/gas interfaces, there are practically no studies in which surface energies have been determined for different shales. The surface energy, as well as dispersive, non-dispersive, Lifshitz-van der Waals, and Lewis Acid-Lewis Base components of surface energy of several North American shales have been determined from contact angle measurements. It has been discovered that the surface energy of all shale rocks is rather low, typically in the range of 40-50 mJ/m2 a contribution from non-dispersion ("polar") component of about 8-11 dyn/cm. Consequently, shales are capable of interacting with liquids predominantly via dispersion and Lifshitz-van der Waals molecular interactions, which should substantially influence the orientation of surfactant molecules and microemulsion moieties at the shale surface. Furthermore, there was no significant variation in surface energy of shales from different basins, which suggests that individuality of shale surface chemistry should play only a secondary role in the development of shale-specific chemical treatments, and factors other than surface chemistry should be considered first.
Variability in a Short Tandem Repeat Mediates Complex Epistatic Interactions in <i>Arabidopsis thaliana</i> (2016)

Short tandem repeats (STRs) are hypervariable genetic elements that occur frequently in coding regions. Their high mutation rate readily generates genetic variation, contributing to adaptive evolution and human diseases. We previously reported that natural ELF3 polyglutamine variants cause reciprocal genetic incompatibilities in two divergent Arabidopsis thaliana backgrounds. Here, we dissect the genetic architecture of this incompatibility, revealing as many as four loci putatively interacting with ELF3 We were able to specifically identify one such ELF3-interacting gene, LSH9 We further used a yeast two-hybrid strategy to identify proteins whose physical interactions with ELF3 were affected by polyglutamine tract length. We found two proteins for which this was the case, ELF4 and AtGLDP1. Using these two approaches, we identify specific genetic interactions and physical mechanisms by which the ELF3 polyglutamine tract may mediate the observed genetic incompatibilities. Our work elucidates how STR variation, which is generally underascertained in population-scale sequencing, can contribute to phenotypic variation. Furthermore, our results support our proposal that highly variable STR loci can contribute to the epistatic component of heritability.
Differential Determinants for Peptide and Non-peptidyl Ligand Binding to the Motilin Receptor (2002)

The predicted second extracellular loop domain of the motilin receptor is of particular interest because it is a region that is quite distinct from the analogous regions in other family members that are most closely related and because the initial report of the photoaffinity labeling of a domain of this receptor included this region (Coulie, B. J., Matsuura, B., Dong, M., Hadac, E. M., Pinon, D. I., Feighner, S. D., Howard, A. D., and Miller, L. J. (2001) J. Biol. Chem. 276, 35518-35522). In the current work, motilin receptor constructs were prepared that included sequential deletions ranging from single residues to twelve amino acid segments throughout this 67 amino acid domain. Each construct was expressed in COS cells and characterized for motilin radioligand binding and motilin-stimulated intracellular calcium responses. The only segments that had negative impact on motilin binding and biological activity included deletion constructs DeltaCys(235), Delta179-182, and Delta241-246. Cys(235) is likely involved in the highly conserved and functionally important disulfide bond linking the first and second loops of G protein-coupled receptors. Alanine replacements for each of the amino acid residues in the other two segments revealed that the perimembranous residues at both ends of this loop, Val(179) and Leu(245) and Arg(246), were responsible for the negative impact on motilin binding and biological activity. Of note, these mutants responded normally to the non-peptidyl agonist, erythromycin. These data support important functional roles for both amino-terminal and carboxyl-terminal perimembranous regions of the second loop for responses to the natural agonist peptide, while supporting independent determinants for action of a non-peptidyl agonist ligand.
A novel mutation of <i>CHRNA4 responsible for autosomal dominant nocturnal frontal lobe epilepsy</i> (1999)

C755T is a novel missense mutation of the CHRNA4 gene causing autosomal dominant nocturnal frontal lobe epilepsy in this Japanese family.
Fast Finger Selection for GRAKE (2005)

This paper presents a low complexity finger selection method for the generalized RAKE receiver (GRAKE). GRAKE is an attractive receiver for CDMA systems, exhibiting nice gains over the standard RAKE receiver in dispersive channels, while maintaining the same structure. GRAKE is a linear whitening receiver, treating various sources of interference as colored noise. A GRAKE receiver makes use of so-called noise fingers (i.e. fingers not aligned with multipath delays) to effect interference suppression. Our method focuses on the selection of a subset of noise fingers to combine along with the standard signal fingers. We derive an exact expression for the SNR increment due to the placement of an extra finger, and an easily computed approximation to that expression. We describe two variants of a simple search algorithm based on the approximate SNR increment. We test the performance of our algorithm for the WCDMA system. Our simulation results show that GRAKE with our method exhibits gains of about 2 dB over RAKE. Our method also matches the performance of the more complex ML search algorithm, and it comes within 1/2 dB of an idealized GRAKE receiver.
Expression of monocyte chemoattractant protein 1 (MCP-1) in vivo (1994)

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Stretchable electronic platform for soft and smart contact lens applications (2017)

A stretchable platform with spherical-shaped electronics based on thermo- plastic polyurethane (TPU) is introduced for soft smart contact lenses. The low glass transition temperature of TPU, its relatively low hardness, and its proven biocompatibility (i.e., protection of exterior body wounds) fulfill the essential requirements for eye wearable devices. These requirements include optical transparency, conformal fitting, and flexibility comparable with soft contact lenses (e.g., hydrogel-based). Moreover, the viscoelastic nature of TPU allows planar structures to be thermoformed into spherical caps with a well-defined curvature (i.e., eye’s curvature at the cornea: 9 mm). Numerical modeling and experimental validation enable fine-tuning of the thermo - forming parameters and the optimization of strain-release patterns. Such tight control is proven necessary to achieve oxygen permeable, thin, nonde- velopable, and wrinkle-free contact lenses with integrated electronics (silicon die, radio-frequency antenna, and stretchable thin-film interconnections). This work paves the way toward fully autonomous smart contact lenses potentially for vision correction or sensing applications, among others.
Orbitron Pump of 30-cm Diameter (1964)

An Orbitron pump of 30-cm diameter was constructed and performance was studied as parameters were varied. The pump arrangement chosen gave pumping speed values of 105 liters/sec for argon, 4500 liters/sec for air, 6000 liters/sec for nitrogen, and 9000 liters/sec for hydrogen.