gebhart/patrepeval huggingface dataset:
A 3D vision system for robotics (1988)

Presents an overview of the Sheffield AIVRU 3D vision system for robotics. The system currently supports model based object recognition and location; its potential for robotics applications is demonstrated by its guidance of a UMI robot arm in a pick and place task. The system is currently being developed to allow robot navigation by utilising visual feedback. The idea is to exploit the temporal coherence that exist in a sequence of images in order to provide quickening strategies.
Product Burn-in Stress Impacts on SRAM Array Performance (2007)

Product burn-in stresses are commonly performed on SRAM array to accelerate transistor failure mechanism and screen out weak SRAM cells. For sub-100 nm technology, the possible impacts from burn-in stress are negative bias temperature instability (NBTI) (Schroder and Babcock, 2003) on PFET and hot carrier effect (HCE) on NFET. Recently several groups (Muller et al., 2004 and LaRosa et al., 2006) reported the studies of NBTI impact on SRAM array performance, either using circuit simulation (Muller et al., 2004) or based on test results of discrete SRAM cell (LaRosa et al., 2006). Our study, for the first time, is directly based on the product results from burn-in stress on SRAM array. With device reliability models and circuit simulation, we analyzed the shift of key product parameters: SRAM array stand-by current (Iddq) and minimum array operation voltage (Vcsmin). Our studies show that PFET NBTI is the dominant factor that is responsible for the degradation of SRAM array stability, and its impact on Vcsmin is predictable by Iddq data and modeling.
End-to-End Emotional Speech Synthesis Using Style Tokens and\n Semi-Supervised Training (2019)

This paper proposes an end-to-end emotional speech synthesis (ESS) method\nwhich adopts global style tokens (GSTs) for semi-supervised training. This\nmodel is built based on the GST-Tacotron framework. The style tokens are\ndefined to present emotion categories. A cross entropy loss function between\ntoken weights and emotion labels is designed to obtain the interpretability of\nstyle tokens utilizing the small portion of training data with emotion labels.\nEmotion recognition experiments confirm that this method can achieve one-to-one\ncorrespondence between style tokens and emotion categories effectively.\nObjective and subjective evaluation results show that our model outperforms the\nconventional Tacotron model for ESS when only 5\\% of training data has emotion\nlabels. Its subjective performance is close to the Tacotron model trained using\nall emotion labels.\n
Development of a Practical and Scalable Synthesis of (<i>R</i>)- and (<i>S</i>)-3-Amino-2-[(benzyloxy)methyl]propan-1-ol Monohydrochloride: A Useful C-4 Chiral Building Block (2012)

The development of a practical and scalable synthesis of a C-4 chiral amine building block (R)-1·HCl and (S)-1·HCl is described. This important chiral intermediate (R)-1·HCl is efficiently synthesized from the commercially available, inexpensive, and simple 2-(hydroxymethyl)-1,3-propanediol (31) using lipase-catalyzed enantioselective hydrolysis as a key reaction. Development resulted in a telescoped process that was operated successfully and reproducibly in a pilot-plant-scale synthesis, and 22 kg of chiral amine (R)-1·HCl was prepared in the first scale-up synthesis. This synthetic method is also useful for preparation of the important chiral building block (S)-1·HCl, which is the enantiomer of (R)-1·HCl.
Polyspectra-based, blind, MMSE, fractionally-spaced equalization of a cyclostationary signal (1993)

Two weaknesses of polyspectra-based blind equalization are addressed. The first weakness involves a zero-forcing (ZF) characteristic, where intersymbol interference is eliminated with disregard for associated mean squared error (MSE). It is shown that a minimum-MSE (MMSE) constraint can be added for signals operating in colored Gaussian noise, with only a small increase in computational complexity and with performance enhancement under certain scenarios. The second weakness involves the constraint that the signal be stationary, which fails to exploit the cyclostationary features of most communication signals (W. A. Gardner). In particular, it is shown that polyspectra-based techniques can be used with a fractionally-spaced equalizer, with attendant performance boosts in timing insensitivity (S. H. Qureshi, 1985) and damaged-spectrum restoration (W. A. Gardner, 1991). The technique decomposes the signal into stationary streams, computing the individual and joint statistics of the partitions, and then solves the optimal Wiener equation.< <ETX>></ETX>
Computer simulation of the human-body effects on a circular-loop-wire antenna for radio-pager communications at 152, 280, and 400 MHz (1997)

This paper presents an extensive computer simulation of the influence of the human body on a circular-loop-wire antenna to simulate the pager antenna. The coupled integral equations (CIEs) approach and the method of moments (MoM) are employed for numerical simulation of this antenna-body-coupling problem. The magnetic frill source is used to model the antenna-feeding structure. A realistically shaped full-scale human-body model (1.7 m) is constructed. A small loop antenna (loop radius b=1.7 cm and wire radius a=0.072 cm) of x, y, and z orientation, in free space or proximate to the human body at the top pocket (chest position) or belt level (waist position), is considered. Numerical results of the antenna characteristics and body absorption at 152, 280, and 400 MHz are presented and discussed for radio-paging applications. At 280 MHz, it is found that the real part of the impedance increases about five to ten times, and, hence, the antenna ohmic-loss radiation efficiency increases from 17% (in free space) to 69%, 44.3%, and 58.4%, respectively, for the x-, y-, and z-oriented loops when proximate to the body. The radiation efficiencies, reduced by the body-absorption effect, are 5%, 61%, and 25% for the x-, y-, and z-oriented loops, respectively. For the y-oriented loop, which is found to be the most suitable for paging communications, the antenna efficiencies are almost the same at the two location levels for all frequencies considered. The computed antenna characteristics influenced by the human body; including the input impedance, antenna patterns, cross-polarization field level, radiation efficiencies, and maximum and minimum power gains, are important for the antenna/RF design and the link-budget consideration.
Kinetics of copper drift in PECVD dielectrics (1996)

We quantified the drift of Cu ions into various PECVD dielectrics by measuring shifts in capacitance-voltage behavior after subjecting Cu-gate MOS capacitors to bias-temperature stress. At a field of 1.0 MV/cm and temperature of 100/spl deg/C, Cu ions drift readily into PECVD oxide with a projected accumulation of 2.7/spl times/10/sup 13/ ions/cm/sup 2/ after 10 years. However, in PECVD oxynitride, the projected accumulation under the same conditions is only 2.3/spl times/10/sup 10/ ions/cm/sup 2/. These findings demonstrate the necessity of integrating drift barriers, such as PECVD oxynitride layers, in Cu interconnection systems to ensure threshold stability of parasitic field n-MOS devices.
On-the-fly program modification: systems for dynamic updating (1993)

Several dynamic software-based updating systems that are in the research and production stages are described. In particular, the procedure-oriented dynamic updating system (PODUS) is discussed. In PODUS, a program is updated by loading the new version of the program and replacing each old procedure with its corresponding new procedure during execution. Updating a procedure involves changing the binding from its current version to the new version. When all procedures have been replaced by their corresponding new versions, the program update is completed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Anisotropy in spun single-mode fibres (1982)

It is shown that the dominant process for the reduction of birefringence in a spun fibre is the averaging of the local fibre anisotropy by the rapid procession of the axes of asymmetry along the fibre. No significant change in cross-sectional geometry occurs.
Labor scheduling with employee turnover and absenteeism (2002)

Most labor staffing and scheduling models presume that all employees scheduled for duty reliably report for work at the beginning of their shift. For industries with even moderate turnover or absenteeism, this assumption may be quite costly. We present a profit-oriented labor scheduling model that accounts for the day-to-day flux of employees and capacity induced by voluntary resignations, new hires, experience curves, and absenteeism. The proposed model also anticipates revenue losses due to reneging by customers whose patience decays exponentially with queue time. Our computational studies suggest that firms with comparatively high transaction volumes, long transaction times, and/or relatively tight profit margins may experience significant benefit from this approach. Compared with conventional labor scheduling models, the proposed method boosts average expected profits by more than 10 percent in certain operating environments.
Understanding linearity in wireless communication amplifiers (1997)

This paper investigates the linearity of active devices and amplifiers that have modulated input signals. We describe an implementation of a mathematical technique for calculating spectral regrowth due to the nonlinear amplification of modulated signals typically used in wireless communication systems. This technique only requires knowledge of the single-tone gain and phase data as a function of input power and can be applied to any modulated signal given (a) the device or amplifier characteristics do not change significantly over the bandwidth of the input signal and (b) the modulation frequencies are much less than the carrier frequency. Verification of the mathematical technique is presented using examples of measured and calculated spectra for /spl pi//4-differential quadrature phase shift keying (DQPSK) personal handy phone system (PHS) and code division multiple access (CDMA) Offset-QPSK personal communication system (PCS) modulation schemes. This calculation technique is essential in determining fundamental tradeoffs between device performance (linearity, output power, gain, and power-added efficiency) and device bias conditions and load impedance.
Gelatinization Characteristics of Starch from <i>du, wx, ae</i>, and <i>ae wx</i> Endosperm of Sweet Corn Inbred la5125 (1988)

Abstract Starch gelatinization in excess water was studied by differential scanning calorimetry for the mutants dull (du), waxy (wx) , and amylose extender (ae) , and the double mutant amylose‐extender, waxy (ae wx) from the Ia5125 sweet corn inbred background. Onset temperature (T o ), peak temperature (T max ), and enthalpy (ΔH) were determined. For du and wx starches T max was within 1°C of the value for the normal starch (T max = 69.4°C). For starches from ae and ae wx mutants, T max was 7–8°C higher than the normal starch. The highest enthalpies were observed for wx (3.26 cal/g) and ae wx (3.39 cal/g) starches; ae (2.93 cal/g) and normal (2.52 cal/g) starches were intermediate, and du (2.32 cal/g) starch had the lowest enthalpy. The endotherm of the ae starch was completed at just above 100°C, in distinction to reports for ae mutants from dent lines. Although the ae wx endotherm occurred at a higher temperature than the wx , the endotherm was sharpened relative to the ae endotherm, and was complete at 90°C.
DISTRIBUTION OF TYROSINE HYDROXYLASE IN HUMAN AND ANIMAL BRAIN<sup>1</sup> (1971)

Abstract The activity of tyrosine hydroxylase (EC 1.10.3.1) when assayed under ideal conditions in young human brains, was comparable to that in brains of other species in level of activity and distribution. The highest levels of activity were in the putamen, caudate nucleus and substantia nigra, in keeping with data on other species. The caudate activity in human brain appeared to decrease substantially with increasing age. In both humans and baboons, the enzyme in the neostriatum was particle‐bound and inhibited by the 2‐amino‐4‐hydroxy‐6,7‐dimethyltetrahydropteridine cofactor system. In the substantia nigra it was soluble and stimulated by the 2‐amino‐4‐hydroxy‐6,7‐dimethyltetrahydropteridine cofactor system. The data suggest that tyrosine hydroxylase may be produced in a soluble form in the cell bodies of the substantia nigra but become bound as it moves toward the nerve endings in the putamen and caudate nucleus. The bound form of the enzyme was unstable but the soluble form exhibited considerable stability.
Enhanced therapeutic effect against liver W256 carcinosarcoma with temperature-sensitive liposomal adriamycin administered into the hepatic artery. (1993)

The antitumor activity of Adriamycin encapsulated in temperature-sensitive liposomes combined with local hyperthermia (HT) was tested in rats bearing well-developed liver W256 carcinosarcoma tumors. Two h after rats received Adriamycin encapsulated in temperature-sensitive liposomes via either the hepatic artery (i.a.) or the femoral vein (i.v.) or free Adriamycin i.a., liver HT was applied at 42 degrees C for 6 min. In animals treated with liposomal Adriamycin i.a., HT resulted in a 38% reduction in the tumor volume ratio and a 2.2-fold increase in the life span of the animals. In animals treated with liposomal Adriamycin i.v. or free Adriamycin i.a., HT did not alter the tumor volume ratio or life span of the animals. Administration i.a. of liposomal Adriamycin markedly increased the tumor drug levels (4-14-fold), reduced the systemic distribution of the drug, and slowed the drug decrease from both the tumor and liver compared with animals treated i.v.. Liver HT in animals treated with liposomal Adriamycin i.a. further increased tumor drug levels by 1.5-2.6-fold, further slowed the drug decrease from the tumor, and resulted in a dissociation of the parallel decrease of drug and lipid from the tumor. This latter effect was not observed in the other groups. These pharmacological findings combined with the lack of beneficial effect from HT in animals treated with free Adriamycin i.a. or liposomal Adriamycin i.v. suggest that i.a. administration of Adriamycin encapsulated in temperature-sensitive liposomes results in a significant retention of intact liposomes in the tumor vasculature that are able to release the encapsulated drug into the tumor cell compartment upon raising the temperature to the phase transition level.
Ultrafast All-Optical Light Control with Tamm Plasmons in Photonic Nanostructures (2019)

Ultrafast all-optical modulators are crucial parts of prospective photonic devices. A number of plasmonic and dielectric nanostructures were nominated as candidates for integrated all-optical circuits. The key principle in the design of such devices is to engineer artificial optical resonances to increase the magnitude of modulation or to change the characteristic switching time. The major drawback is that the manufacturing becomes rather sophisticated. Here, we propose a method to tailor the ultrafast response of photonic crystal–metal nanostructures by employing a spectral shift of the Tamm-plasmon resonance. We show that for the absorbed pump fluence of 6 pJ reflectance of the sample at the near-infrared probe wavelength in the vicinity of the Tamm-plasmon resonance changes 25× stronger as compared with a bare metal film. Additionally, we show that by choosing a proper wavelength around the resonance a background-free reflectance modulation can be achieved. The characteristic pulse-limited switching time, in this case, is 150 fs.
Effect of Probucol, An Oral Hypocholesterolaemic Agent, on Acute Tobacco Smoke Inhalation in Rats (1996)

1. We hypothesized that probucol, an oral hypocholesterolaemic agent, can suppress the oxidant stress induced by acute tobacco smoke inhalation in rats. We determined lung tissue glutathione (reduced and oxidized), lipid peroxide, tocopherol and plasma elastase inhibitory capacity, ferroxidase activity and lipid peroxide in rats after inhalation of tobacco smoke. 2. Rats treated with the probucol diet for 3 days or 4 weeks equally showed no suppression of plasma elastase inhibitory capacity and ferroxidase activity compared with control rats after acute tobacco smoke inhalation, although both animals treated with probucol for 3 days or 4 weeks had pharmacologically effective concentrations of probucol to lower plasma cholesterol but plasma cholesterol in rats treated with probucol for 3 days was still in the normal range. 3. Probucol treatment for 4 weeks lessened tobacco smoke-induced suppression of lung tissue glutathione, attenuated tobacco smoke-induced increases in lung tissue lipid peroxide and did not alter lung tissue tocopherol compared with control (lungs). 4. These findings demonstrate that probucol, via its antioxidant ability, confers a protective effect on lung exposed to acute tobacco smoke inhalation.
Robust multi-criteria design optimization in building design (2012)

This paper’s contribution is to increase the ability to predict the impact of design variables using statistical sensitivity analysis on top of building performance simulation (BPS), and based on this find Pareto optimal solutions. To perform the optimisation an evolutionary multi-objective optimisation algorithm (SMS EMOA) was equipped with robustness estimation/uncertainty handling. To allow the optimisation under uncertatiny, Kriging metamodels are used. The design optimisation of an office building located in the Netherlands serves to validate the method. The building is an ideal case study as it combines spacial flexibility (in terms of the office layout) and function.
Distributed Visualization with OpenGL Vizserver: Practical Experiences (2000)

The increasing demand for distributed solutions in computing technology does not stop when it comes to visualization techniques. However, the capabilities of todays applications to perform remote rendering are limited by historical design legacys. Especially the popular X11 protokoll, which has been proven to be extremely flexible and usefull for remote 2D graphics applications, breaks down for the case of remote 3D rendering. In this white paper, we give a short overview of generic remote rendering technologies available today, and compare their performance to the recently released vizserver by SGI: a network extension to the SGI OpenGL rendering engines.
Palladium-Catalyzed Selective Hydrogenolysis of Alkenylcyclopropanes Having Two Electron Withdrawing Groups Using Ammonium Formates (1988)

Abstract Selective hydrogenolysis of vinyl- or 2-(methoxycarbonyl)ethenylcyclopropanes having two electron withdrawing groups was carried out using palladium–phosphine catalysts with ammonium formates. The reaction proceeded with inversion of stereochemistry.
Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ (2021)

Metastasis is the fundamental cause of cancer mortality, but there are still very few anti-metastatic drugs available. Endosomal trafficking has been implicated in tumor metastasis, and we have previously found that small chemical vacuolin-1 (V1) potently inhibits autophagosome-lysosome fusion and general endosomal-lysosomal degradation. Here, we assessed the anti-metastatic activity of V1 both in vitro and in vivo. V1 significantly inhibits colony formation, migration, and invasion of various cancer cells in vitro. It also compromises the assembly-disassembly dynamics of focal adhesions (FAs) by inhibiting the recycling and degradation of integrins. In various experimental or transgenic mouse models, V1 significantly suppresses the metastasis and/or tumor growth of breast cancer or melanoma. We further identified capping protein Zβ (CapZβ) as a V1 binding protein and showed that it is required for the V1-mediated inhibition of migration and metastasis of cancer cells. Collectively, our results indicate that V1 targets CapZβ to inhibit endosomal trafficking and metastasis.
Contrast invariant registration of images (1999)

We propose a method for image registration which seems to be useful under the three following conditions. First, both images are globally and roughly the result of a translation and rotation. Second, some occlusions due to moving objects occur from image 1 to image 2. Third, because of changes of illumination, contrast may have changed globally and even locally. Under such unfavorable conditions, correlation-based global registration may become inaccurate, because of the global compromise it yields between several displacements. Our method avoids these difficulties by defining a set of local contrast invariant features in order to achieve contrast invariant matching. A voting procedure allows one to eliminate "wrong" matching features due to the displacement of small objects and yields sub-pixel accuracy. This method was tested successfully for registration of watches with moving hands and for road control applications.
Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor Threonine<sup>790</sup> → Methionine<sup>790</sup> Mutant (2012)

The EGFR(T790M) mutant contributes approximately 50% to clinically acquired resistance against gefitinib or erlotinib. However, almost all the single agent clinical trials of the second generation irreversible EGFR inhibitors appear inadequate to overcome the EGFR(T790M)-related resistance. We have designed and synthesized a series of 2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives as novel EGFR inhibitors. The most potent compounds, 2q and 2s, inhibited the enzymatic activities of wild-type and mutated EGFRs, with IC(50) values in subnanomolar ranges, including the T790M mutants. The kinase inhibitory efficiencies of the compounds were further validated by Western blot analysis of the activation of EGFR and downstream signaling in cancer cells harboring different mutants of EGFR. The compounds also strongly inhibited the proliferation of H1975 non small cell lung cancer cells bearing EGFR(L858R/T790M), while being significantly less toxic to normal cells. Moreover, 2s displayed promising anticancer efficacy in a human NSCLC (H1975) xenograft nude mouse model.
Information theoretic analysis of postal address fields for automatic address interpretation (1999)

This paper concerns a study of information content in postal address fields for automatic address interpretation. Information provided by a combination of address components and information interaction among components is characterized in terms of Shannon's entropy. The efficiency of assignment strategies for determining a delivery point code can be compared by the propagation of uncertainty in address components. The quantity of redundancy between components can be computed from the information provided by these components. This information is useful in developing a strategy for selecting a useful component for recovering the value of an uncertain component. The uncertainty of a component based on another known component can be measured by conditional entropy. By ranking the uncertainty quantity, the effective processing flow for determining the value of a candidate component can be constructed.