gebhart/patrepeval huggingface dataset:
Reactions of o-Methoxyphenylmagnesium Bromide with Hindered Ketones<sup>1</sup> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of o-Methoxyphenylmagnesium Bromide with Hindered Ketones1Reynold C. Fuson, Rudolph L. Pedrotti, and James C. HillCite this: J. Org. Chem. 1962, 27, 5, 1578–1581Publication Date (Print):May 1, 1962Publication History Published online1 May 2002Published inissue 1 May 1962https://pubs.acs.org/doi/10.1021/jo01052a022https://doi.org/10.1021/jo01052a022research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recent advances in Imaging and Spectroscopy with T-rays (2007)

Recent work in terahertz "T-Ray" imaging is reported.With the ongoing development of commercially viable THz-TDS imaging system, optimal signal processing strategies for the THz waveforms must be developed.Algorithms based on wavelet decomposition of the time and frequency-localized signals offer a number of advantages.Examples of denoising, deconvolution, and other waveform analysis tools are described.
Blind estimation of the coherent-to-diffuse energy ratio from noisy speech signals (2011)

A novel dual-channel algorithm is proposed which estimates the coherent-to-diffuse energy ratio (CDR) of background noise in mixed noise fields. The algorithm is based on an estimate of the noise field coherence from a noisy speech signal and a subsequent minima tracking in order to increase the estimation accuracy even in the presence of speech. The obtained CDR estimate can be used, e.g., for the acoustic environment classification in hearing aids or to control speech enhancement algorithms such as noise reduction or speech dereverberation. Besides, the approach can be used to calculate an estimate of the direct-to-reverberant energy ratio (DRR) blindly from reverberant speech signals. 1.
Sculpting Nanoelectrodes with a Transmission Electron Beam for Electrical and Geometrical Characterization of Nanoparticles (2005)

A method to produce metal electrodes with a gap of a few nanometers with a highly focused electron beam in a transmission electron microscope (TEM) is described. With this method the electrical and geometrical characterization of the same particle is possible. The I-V characteristics of a gold particle trapped between such electrodes showed the expected single-electron tunneling behavior, with a Coulomb gap corresponding to the geometry of the particle as observed with high-resolution TEM.
<title>Compact Real-Time Matched-Filter Optical Processor</title> (1977)

A matched filter optical processor is described that is compact, lightweight, and operates in real time. The use of lightweight reflection hologram lenses as the Fourier transforming elements allows for compact folded light paths. The holographic optical elements were designed and analyzed using a holographic optics ray-tracing computer program (HOAD). It was predicted that compact holographic optics can perform satisfactorily for input imagery of moderate space-bandwidth product; high performance can be achieved if longer focal lengths (1 meter) are allowed. A photoconductor-thermoplastic (PTP) device at the input plane of the processor provides for real-time data insertion. Data is scanned or imaged from an incoherent source onto the PTP device, which forms a phase recording that modulates the coherent illumination at the processor input. The PTP device operates in real-time and can be erased and reused many times. Compact optical processors of the type described are particularly well suited to applications such as space vehicle data processing or terrain-matching for terminal guidance.© (1977) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
How should monetary policy respond to shocks while maintaining long-run price stability? Conceptual issues (1996)

Monetary policy; Prices
Hierarchical adaptive routing: a framework for fully adaptive and deadlock-free wormhole routing (2002)

Adaptive routing can improve network performance and fault-tolerance by providing multiple routing paths. However, the implementation complexity of adaptive routing can be significant, discouraging its use in commercial massively parallel systems. In this paper we introduce Hierarchical Adaptive Routing (HAR), a new adaptive routing framework which provides a unified framework for simple and high performance fully adaptive deadlock-free wormhole routing. HAR divides the physical network into several levels of virtual networks. There is one connection channel between two adjacent virtual networks that allows blocked packets in the higher level to move to the lower level. Different routing algorithms can be used in each virtual network; and the overall network is deadlock-free provided the rotating algorithm in the lowest level virtual network is deadlock-free. However, the routing algorithm in any other virtual network can be fully adaptive, even non-minimal, to increase performance. HAR has three advantages: fully adaptive deadlock-free routing in any non-wrapped and wrapped k-ary n-cube network with 2 and 3 virtual channels respectively, relatively small crossbars, and applicability to a wide variety of network topologies. Detailed implementation and simulation studies of a HAR for 2D mesh networks are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Identification and characterization of a pituitary corticotropin-releasing factor binding protein by chemical cross-linking. (1987)

A corticotropin-releasing factor (CRF) binding protein has been identified based on the chemical cross-linking of ovine [Nle21,m-125I-Tyr32]CRF (125I-oCRF) to bovine anterior pituitary membranes using disuccinimidyl suberate (DSS). The apparent molecular weight of the cross-linked complex determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by autoradiography was approximately 75,000 and was slightly decreased in its nonreduced state, suggesting the presence of intramolecular disulfide bonds. Subtracting the molecular weight of 125I-oCRF, the binding protein appeared to have a molecular weight of approximately 70,000. The cross-linking was specific since an excess (1 microM) of an unrelated peptide (insulin) did not affect the appearance of the Mr 75,000 band. The concentration of CRF required to inhibit cross-linking by 50% was found to be similar to that determined for bovine pituitary CRF receptors by radioreceptor assay. The nonhydrolyzable GTP analogue 5'-guanylylimidodiphosphate dose dependently inhibited the cross-linking of 125I-oCRF to the Mr 70,000 protein. 50 nM of the inactive CRF analogue, [Ala14]oCRF, had no effect on the cross-linking, an observation which is consistent with this compound's low potencies in bioassays and radioreceptor assays. These results strongly suggest that this Mr 70,000 protein is the biological bovine anterior pituitary CRF receptor.
Intelligent network news reader (1997)

We are developing an Intelligent Network News Reader which extracts news articles for the user. In contrast to ordinary information retrieval and abstract generation, this method utilizes an "information context" to select articles from newsgroups on the intemet.
Control of Hep G2-cell triacylglycerol and apolipoprotein B synthesis and secretion by polyunsaturated non-esterified fatty acids and insulin (1992)

Non-esterified fatty acids (NEFAs) and insulin are important factors in the control of lipoprotein secretion, but the mechanism of action is unclear. The present study was undertaken to determine whether insulin and NEFAs modulated hepatic secretion of triacylglycerol and apolipoprotein B (apo-B) by regulation of hepatic intracellular apo-B content. The experiments were performed with the human hepatoblastoma cell line Hep G2, for periods of up to 72 h in the presence and absence of NEFAs and insulin. Higher concentrations of eicosapentanoate (EPA) sustained for 72 h decreased cellular protein content (at 250 microM) or caused cell death (at 750 microM), and this effect was not observed with the other NEFAs studied, whereas 75 microM-EPA did not affect cell viability. Compared with the absence of NEFA, 75 microM-EPA did not alter the intracellular triacylglycerol content, but decreased the intracellular content of apo-B by 47% (P < 0.01) and decreased secreted triacylglycerol and secreted apo-B by 13% (P < 0.05) and 21% (P < 0.01) respectively, after 72 h. However 250 microM-oleate increased the intracellular triacylglycerol by 36% (P < 0.01), intracellular apo-B by 22% (P < 0.05) and secreted triacylglycerol and apo-B by 20-30% (P < 0.05-0.01). Insulin decreased secreted triacylglycerol and apo-B in the presence of each NEFA studied by 20-30%. There was no correlation between the changes in intracellular triacylglycerol and the rate of secretion. However, when the secreted triacylglycerol or apo-B was plotted against intracellular apo-B content a significant correlation was observed (r = 0.89, P < 0.001 for both analyses). Apo-B mRNA levels did not change after 72 h incubation with oleate or EPA. These results demonstrate that EPA can be toxic to hepatocytes and that NEFAs and insulin control secretion of triacylglycerol and apo-B by regulation of the intracellular apo-B concentration, thus controlling assembly of apo-B with triacylglycerol to form lipoproteins.
Two-dimensional visualization of fluorescence lifetimes by use of a picosecond laser and a streak camera (1998)

Two-dimensional distributions of the effective lifetime of the fluorescence emission induced by short-pulsed laser radiation are obtained from two-dimensional images recorded with a streak camera and a charge-coupled device by means of a separation algorithm method (SAM). In theory, the best response with respect to noise is obtained for lifetimes corresponding to a range of pixels of 5-50 in the CCD, that is, 5-50 ps at the fastest streak speed. In experiments the SAM is compared with pure time-resolved measurements, and it is used for two-dimensional lifetime evaluation. The laser-pulse duration is 25 ps, and the lower limit of the lifetime resolution as used in the experiments is estimated to be 200-250 ps. The results demonstrate the possibility of performing pattern recognition independently of the relative distribution of emission intensity between regions of different fluorescence lifetimes. The technique is demonstrated for static objects but can in principle be extended to nonstationary objects if two detectors are used.
Is Sotalol more effective than standard beta-blockers for the prophylaxis of atrial fibrillation during cardiac surgery (2005)

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether prophylactic Sotalol was more effective than conventional beta blockers in the prevention of atrial fibrillation after cardiac surgery. Fifty-one papers were found of which eight presented the best evidence to answer the question. The author, journal, date and country of publication, patient group, relevant outcomes and weaknesses were tabulated. We conclude that prophylactic Sotalol may be more effective than beta blockers in the prevention of post operative atrial fibrillation, and should not cause an excess of side effects.
A NOTE ON SAINT-EXUPÉRY AND FREUD (1999)

Journal Article A NOTE ON SAINT-EXUPÉRY AND FREUD Get access S. BEYNON JOHN S. BEYNON JOHN Sussex Search for other works by this author on: Oxford Academic Google Scholar French Studies Bulletin, Volume 20, Issue 72, AUTUMN 1999, Pages 3–6, https://doi.org/10.1093/frebul/20.72.3 Published: 01 October 1999
Survey of foreign maglev systems (1992)

Magnetic levitation (maglev) transportation systems represent an innovative technology that promises to provide pollution-free, contact-free, high-speed ground transportation for the twenty-first century. Great interest in maglev systems has been developing in the United States over the past two years under the auspices of the US National Maglev Initiative. The objective of the survey presented in this report is to provide the US maglev community with information on various maglev concepts that were developed in foreign countries over the past two decades. The main maglev systems included in the survey are the German Transrapid series and the M-Bahn, the Japanese HSST and MLU series, and the British Birmingham. Each maglev system is introduced and discussed according to its type, historical development, unique features, current status, and future prospects. Advantages and disadvantages of each system are briefly noted.
An Evaluation of Structural Descriptors and Clustering Methods for Use in Diversity Selection (1998)

An evaluation of the suitability of a number of structural descriptors and clustering methods for use in diversity selection is presented. The methods are compared by their success in simulated biological activity predictions. The results suggest that simple 2D structural descriptors are particularly effective and that hierarchical clustering methods are superior to the non-hierarchical methods traditionally used for diversity related tasks. Results are presented which suggest that the difference in the utility of the descriptors can be accounted for by the different extent to which each encodes information relevant to the forces of ligand-receptor binding.
Nonlinear dynamics of dry friction (1997)

The dynamical behavior caused by dry friction is studied for a spring-block system pulled with constant velocity over a surface. The dynamical consequences of a general type of phenomenological friction law (stick-time dependent static friction, velocity dependent kinetic friction) are investigated. Three types of motion are possible: Stick-slip motion, continuous sliding, and oscillations without sticking events. A rather complete discussion of local and global bifurcation scenarios of these attractors and their unstable counterparts is present.
Comparison of three atmospheric data in a solar spectrum atmospheric correction system (2004)

In this paper, a two-step atmospheric correction system for solar spectrum is presented. In addition, the results when using MASS (Mesoscale Atmospheric Simulation System) forecasted data, radiosoundings and standard profiles are compared. The first step of the system is a semi-empirical model and it includes radiative transfer simulation from the 6S (Second Simulation of the Satellite Signal in the Solar Spectru,) code. The second step is an empirical model based on pseudo-invariant areas located by means of of a TC (Tasselled Cap) transformation. The atmospheric corrections were performed on a multitemporal series of Landsat 7 panchromatic images from Barcelona. After the first step, the best result was achieved using standard atmospheric data. After the second step, similar results were obtained with all three kinds of data.
An Isolated, bridgeless, quasi-resonant ZVS-switching, buck-boost single-stage AC-DC converter with power factor correction (PFC) (2017)

The number of power supplies connected to the public household power grid is constantly increasing. For a good mains voltage quality, the harmonic input currents are limited in standards. Many applications also require a lower output voltage with isolation. Today, this is mostly obtained via a multi-stage converter, consisting of a diode bridge rectifier, a boost PFC and a DC-DC converter with galvanic isolation. For higher efficiency, a bridgeless PFC-stage can be used, but it nevertheless requires a DC-DC converter for isolation. In order to further increase efficiency and decrease component count, a single-stage concept can be used. The Cuk “True Bridgeless PFC” rectifier system, for example, can perform all the requirements in a single stage. A simple application and realization of a converter topology is also quite important, especially in consumer electronics, where costs are crucial. In this paper, a new single stage topology with a different operation principle is presented, focusing on ease of use in hardware realization.
An evaluation of methods for the isolation of nontuberculous mycobacteria from patients with cystic fibrosis, bronchiectasis and patients assessed for lung transplantation (2019)

In the largest study of RGM medium to date, we reaffirm its utility for isolation of NTM from patients with CF. Furthermore; we show that it also provides an effective tool for culture of respiratory samples from patients with bronchiectasis and other lung diseases.
Quantum Dots Leave the Light On (2005)

ADVERTISEMENT RETURN TO ISSUEPREVFeaturesNEXTQuantum Dots Leave the Light OnKatie CottinghamCite this: Anal. Chem. 2005, 77, 17, 354 A–357 APublication Date (Web):September 1, 2005Publication History Published online1 September 2005Published inissue 1 September 2005https://pubs.acs.org/doi/10.1021/ac053454thttps://doi.org/10.1021/ac053454tnewsACS Publications. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views497Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (165 KB) Get e-Alertsclose SUBJECTS:Quantum dots Get e-Alerts
Autophagy and Non-Alcoholic Fatty Liver Disease (2014)

Autophagy, or cellular self-digestion, is a catabolic process that targets cell constituents including damaged organelles, unfolded proteins, and intracellular pathogens to lysosomes for degradation. Autophagy is crucial for development, differentiation, survival, and homeostasis. Important links between the regulation of autophagy and liver complications associated with obesity, non-alcoholic fatty liver disease (NAFLD), have been reported. The spectrum of these hepatic abnormalities extends from isolated steatosis to non-alcoholic steatohepatitis (NASH), steatofibrosis, which sometimes leads to cirrhosis, and hepatocellular carcinoma. NAFLD is one of the three main causes of cirrhosis and increases the risk of liver-related death and hepatocellular carcinoma. The pathophysiological mechanisms of the progression of a normal liver to steatosis and then more severe disease are complex and still unclear. The regulation of the autophagic flux, a dynamic response, and the knowledge of the role of autophagy in specific cells including hepatocytes, hepatic stellate cells, immune cells, and hepatic cancer cells have been extensively studied these last years. This review will provide insight into the current understanding of autophagy and its role in the evolution of the hepatic complications associated with obesity, from steatosis to hepatocellular carcinoma.
Estrogen receptors alpha and beta in the normal, hyperplastic and carcinomatous human prostate (2001)

Two different estrogen receptors (ER-alpha and ER-beta) have been described, which are differentially involved in regulating the normal function of reproductive tissues. ER-alpha was considered for a long time to be the only estrogen receptor, and it has been detected in the stromal cells of the human prostate but not in the epithelium. To obtain new information about the differential effects of both receptor types, we have investigated their localization in normal prostates, benign prostatic hyperplasia (BPH), and prostatic cancer (PC) by immunohistochemistry, ELISA and Western blot. Epithelial immunostaining was absent in normal prostates and was present in BPH (10% of cells) and PC (80% of cells), whereas about 15% of stromal cells were positively immunostained for ER-alpha in the three types of prostatic specimens studied. Epithelial immunostaining for ER-beta was detected in normal prostates (13% of cells), BPH (30% of cells) and PC (79% of cells), whereas stromal immunostaining for ER-beta was absent in normal and hyperplastic prostates and was present in PC (12% of cells). The complementary presence of both receptor types in the normal prostate (ER-beta in the epithelium and ER-alpha in the stroma) might explain the mechanism of estrogen action in the development of BPH. The increased epithelial immunostaining for both ER-alpha and ER-beta in BPH and PC suggests that the involvement of estrogen receptors in hyperplasia and cancer concerns mainly the epithelium.
Natural Language Processing Model for Managing Maintenance Requests in Buildings (2020)

In recent years, facility management (FM) has adopted many computer technology solutions for building maintenance, such as building information modelling (BIM) and computerized maintenance management systems (CMMS). However, maintenance requests management in buildings remains a manual and a time-consuming process that depends on human management. In this paper, a machine-learning algorithm based on natural language processing (NLP) is proposed to classify maintenance requests. This algorithm aims to assist the FM teams in managing day-to-day maintenance activities. A healthcare facility is addressed as a case study in this work. Ten-year maintenance records from the facility contributed to the design and development of the algorithm. Multiple NLP methods were used in this study, and the results reveal that the NLP model can classify work requests with an average accuracy of 78%. Furthermore, NLP methods have proven to be effective for managing unstructured text data.
Pruritus: still a challenge (2012)

Pruritus is a symptom that may be associated with a wide array of diseases - skin diseases, systemic diseases or even those without a defined cause. According to its severity and evolution, it may compromise the patients' quality of life in a significant way. New therapeutic approaches, in which histamine release is not the main event, are being described for pruritus control. Therefore, taking into account the origin of the mediators of pruritus, we conducted a review of the available resources emphasizing that, although very important, anti-histamines are not the answer for every kind of pruritus.