gebhart/patrepeval huggingface dataset:
Apoptotic Membrane Blebbing Is Regulated by Myosin Light Chain Phosphorylation (1998)

The evolutionarily conserved execution phase of apoptosis is defined by characteristic changes occurring during the final stages of death; specifically cell shrinkage, dynamic membrane blebbing, condensation of chromatin, and DNA fragmentation. Mechanisms underlying these hallmark features of apoptosis have previously been elusive, largely because the execution phase is a rapid event whose onset is asynchronous across a population of cells. In the present study, a model system is described for using the caspase inhibitor, z-VAD-FMK, to block apoptosis and generate a synchronous population of cells actively extruding and retracting membrane blebs. This model system allowed us to determine signaling mechanisms underlying this characteristic feature of apoptosis. A screen of kinase inhibitors performed on synchronized blebbing cells indicated that only myosin light chain kinase (MLCK) inhibitors decreased blebbing. Immunoprecipitation of myosin II demonstrated that myosin regulatory light chain (MLC) phosphorylation was increased in blebbing cells and that MLC phosphorylation was prevented by inhibitors of MLCK. MLC phosphorylation is also mediated by the small G protein, Rho. C3 transferase inhibited apoptotic membrane blebbing, supporting a role for a Rho family member in this process. Finally, blebbing was also inhibited by disruption of the actin cytoskeleton. Based on these results, a working model is proposed for how actin/myosin II interactions cause cell contraction and membrane blebbing. Our results provide the first evidence that MLC phosphorylation is critical for apoptotic membrane blebbing and also implicate Rho signaling in these active morphological changes. The model system described here should facilitate future studies of MLCK, Rho, and other signal transduction pathways activated during the execution phase of apoptosis.
Persuasion as a Prelude to Proof: Theory Acceptance in Accounting Research (2013)

In his 2013 presidential scholar address to the American Accounting Association, Michael Jensen, an early author of agency theory, makes an appeal for a new language and new paradigm to introduce his proposed theory of integrity in accounting. In the 1970s, agency theory was promoted over other theories because it demonstrated empirical evidence of the accounting procedures actually used in practice, compared to those that “should” be used according to established rules (see Jensen and Meckling, 1976). Contrarily, in this paper, we show scientific theories (Latour, 1987), and in particular accounting theories, are actually accepted by a larger persuasion than just the empirical evidence. The early empirical evidence on agency theory was often not even statistically significant. As Jensen now demonstrates, consistent with Latour (1987), this persuasion ...
Museums and their Websites: An Examination and Assessment of How Museums are Coping with the Challenge of the World Wide Web (1997)

Internet traffic has increased dramatically over the past two years, due mainly to developments in the World Wide Web. Museum websites are also appearing on-line at an equally rapid pace. In this study, I shall examine how museums are coping with the challenge of the World Wide Web. This will be done through a combination of case studies, interviews, and an interchange of ideas/opinions with museum professionals world-wide, via the Internet.
Physicians and the Changing Medical Marketplace (1999)

As the 20th century closes, the practice of medicine in the United States faces challenges as great as it ever has. On the one hand, medical science and technology have brought unimaginable benefits to the American population. On the other hand, these advances have contributed to the escalation of health care costs above what many people are able to pay. Physicians are caught in the middle — pressured by private and governmental purchasers of health care to keep costs down, while driven by the public and their own professional standards to do everything that might be beneficial for each patient. . . .
Abstract 5766: Multifunctional biologics for targeted T-cell therapy based on <i>in vivo</i> matured fully human VH domains (2018)

Abstract Crescendo Biologics has created a proprietary transgenic mouse devoid of any antibody light chains from which it generates highly diverse fully human VH domain (‘Humabody') building blocks. In vivo maturation optimizes Humabody potency and develops superior biophysical properties. Their small size (13kDa) and high stability permits Humabody assembly into an almost limitless array of multifunctional formats optimally configured for therapeutic efficacy. These small versatile single VH domain building blocks permit the rapid exploration of a vast range of 3D format space to identify optimal therapeutic solutions. This fully modular plug & play approach lacks the constraints of traditional mAbs and enables a radical rethink of how a multifunctional molecule can be designed and assembled to deliver enhanced therapeutic benefit. Such molecules are capable of target engagement that is unachievable using regular mAbs. Using Humabody VH addressing key targets in the immune-oncology space, Crescendo has exemplified the potential for optimally configured molecules to deliver enhanced efficacy both in vitro and in vivo. Examples include: CB307, a unique T-cell engaging format with a novel mode of action. CB201, a biparatopic antagonist which ‘handcuffs' PD1: one domain binding and blocking PD1 from engaging with its ligands, the other binding a nonblocking epitope. With a binding affinity of 175pM and a unique ability to localise rapidly to PD-1 positive T-cells, CB201 demonstrates significantly enhanced in vivo efficacy over IgG-based PD-1 antagonists in a PDX tumour model in NSG mice. CB108, a half-life extended paratopic Humabody binding PSMA has demonstrated superior tumour targeting with enhanced internalisation and highly efficient accumulation in target-positive tumours with up to 18 percent ID per g recorded in a 24hr imaging study. These data support the progression of highly differentiated therapeutics into the clinic. Citation Format: Brian Mcguinness, James Legg, Phil Bland-Ward, Peter Pack. Multifunctional biologics for targeted T-cell therapy based on in vivo matured fully human VH domains [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5766.
A new potentially toxic <i><scp>A</scp>zadinium</i> species (<scp>D</scp>inophyceae) from the <scp>M</scp>editerranean Sea, <i><scp>A</scp>. dexteroporum</i> sp. nov. (2013)

A new photosynthetic planktonic marine dinoflagellate, Azadinium dexteroporum sp. nov., is described from the Gulf of Naples (South Tyrrhenian Sea, Mediterranean Sea). The plate formula of the species, Po, cp, X, 4', 3a, 6″, 6C, 5?S, 6‴ and 2″″, is typical for this recently described genus. Azadinium dexteroporum is the smallest rep-resentative of the genus (8.5 μm average length, 6.2 μm average width) and shares the presence of a small antapical spine with the type species A. spinosum and with A. polongum. However, it differs from all other Azadinium species for the markedly asymmetrical Po plate and the position of the ventral pore, which is located at the right posterior end of the Po plate. Another peculiarity of A. dexteroporum is the pronounced concavity of the second intercalary plate (2a), which appears collapsed with respect to the other plates. Phylogenetic analyses based on the large subunit 28S rDNA (D1/D2) and the internal transcribed spacer (ITS rDNA) support the attribution of A. dexteroporum to the genus Azadinium and its separation from the other known species. LC/MS-TOF analysis shows that Azadinium dex-teroporum produces azaspiracids in low amounts. Some of them have the same molecular weight as known compounds such as azaspiracid-3 and -7 and Compound 3 from Amphidoma languida, as well as similar fragmentation patterns in some cases. This is the first finding of a species producing azapiracids in the Mediterranean Sea.
Porcine proliferative enteritis: experimentally induced disease in cesarean-derived colostrum-deprived pigs. (1982)

The hypotheses that porcine proliferative enteritis is an infectious disease and that Campylobacter sputorum subsp mucosalis (CSM) is involved in the development of this disease were experimentally tested. Three experiments were conducted with 10-week-old, cesarean-derived colostrum-deprived pigs. Of 22 pigs given homogenized mucosal scrapings (crude inocula) intragastrically, 15 had gross and/or microscopic lesions of proliferative enteritis. Of 10 pigs inoculated with cultures of both CSM and Salmonella cholerae-suis, 2 had evidence of proliferative enteritis. The 4 pigs treated with S cholerae suis only had diffuse fibrinous gastroenteritis without evidence of mucosal proliferation. Proliferative enteritis was produced in 1 of 5 pigs inoculated with pure cultures of CSM. Proliferative lesions in the intestine were characterized by the proliferation of immature crypt epithelial cells. Affected cells contained variable numbers of curved, intracytoplasmic Campylobacter sp organisms. The CSM organism was isolated from the intestinal mucosa of 8 pigs treated with either crude inocula or cultures of CSM.
Saline Pco2 is an important source of error in the assessment of gastric intramucosal pH (1994)

Objective: To determine whether the measurement error of saline Pco2, using blood gas analyzers, is relevant for the interpretation and clinical use of the gastric intramucosal pH measurement. Design: A comparison of four different blood gas analyzers (ABL-520, Ciba Corning, IL-1302, and Nova), using tonometered saline as the reference. Setting: Clinical laboratory of a university hospital intensive care unit. Interventions: None. Measurements and Main Results: The bias and the precision of each blood gas analyzer was determined for measurements of Pco2 in saline samples. These samples had been balanced to Pco2 levels of 30, 45, and 68 torr (4, 6, and 9 kPa, respectively). In addition, the effect of buffering the saline was evaluated. The bias of the Pco2 measurement increased (p < .001) at the higher Pco2 levels. The bias ranged from -5.2 to -25.9 torr (-0.69 to -3.45 kPa) at a Pco2 of 45 torr (6 kPa) and from -5.2 to -33.1 torr (-0.69 to -4.41 kPa) at a Pco2 of 68 torr (9 kPa), and there was a significant (p< .001) analyzer-Pco2 level interaction. The type of the analyzer also influenced the bias (p< .001). The Nova analyzer underestimated the Pco2 by 50% to 60%. The other analyzers underestimated the Pco2 by 5% to 19%. The use of the buffer reduced the bias of all analyzers (p< .001). Based on the precision of the saline Pco2 measurement, a difference in gastric intramucosal pH of 0.06 pH units can be reliably detected at a Pco2 of 45 torr (6 kPa) by all analyzers, with the exception of the Nova analyzer. Conclusions: Measurement of saline Pco2 is an important source of error in the assessment of gastric intramucosal pH, and the error depends on both the analyzer used and the actual Pco2 level. Direct comparison of pH values obtained by different analyzers is not valid. Changes in gastric intramucosal pH of 0.06 pH units can be detected by most analyzers in the clinically relevant Pco2 level. (Crit Care Med 1994; 22:1877–1879)
Computers in Nursing: Hospital and Clinical Applications (1987)

From the Publisher:
This manual is useful to any nurse who wants to understand computers and their applications to nursing service in a hospital, this new book brings you the real world experience of two nurse experts who spearheaded the computer socialization process in their hospital.
Structural Characterization and Thermal Stability of MoS<sub>2</sub>Intercalation Compounds (1998)

The intercalation of MoS2 with Co and Fe complexes has been accomplished via exfoliation of LixMoS2 by reaction with water, followed by flocculation in the presence of cationic guest species. The resulting self-assembled compounds have been characterized by X-ray absorption spectroscopy, electron diffraction, powder X-ray diffraction, and magnetic measurements. The 2H-type (undistorted) MoS2 undergoes a structural distortion to 1T-type MoS2 during the Li intercalation, which is partially maintained upon exfoliation and flocculation. A structural model of 1T-MoS2 is proposed on the basis of X-ray absorption spectroscopy and electron diffraction, in which the unit cell has P3 symmetry with lattice parameters a = 6.52(5) Å, c = 6.14 Å. The Mo atoms are shifted approximately 0.5 Å from their positions in 2H-MoS2 to form trigonal clusters in 1T-MoS2, with a concomitant change in coordination geometry from trigonal prismatic to distorted octahedral. Layers of Co(OH)2 were intercalated between the distorted and/or undistorted layers of MoS2 when either Co2+ or Co3+ complexes were used as the flocculating ion. Flocculation of exfoliated MoS2 with (η5-C5H5)2M+ (M = Fe, Co) resulted in intercalation of monolayers of the metallocenium cations between the partially negatively charged MoS2 sheets.
Liquid Crystal Materials for Laser Beam Steering (1994)

Several new liquid crystal compounds have been developed for laser beam steering application. The asymmetric diakyl diphenyl-diacetylenes exhibit a low melting temperature, wide nematic range, high birefringence, low viscosity and small heat fusion enthalpy. They are excellent host materials for forming eutectic mixtures except for the small dielectric anisotropy. To enhance dielectric anisotropy, some polar diphenyl-diacetylenes and tolanes, and a new series of the nitro-azo-benzene dyes have been considered. Among these polar compounds, the nitro-azo-benzene dyes exhibit a mesogenic phase with melting temperature at about 80 deg C huge dielectric anisotropy, excellent solubility and relatively low viscosity. The solubility and viscosity of these dyes are about one order to an asymmetric diphenyl-diacetylene binary mixture reduces its threshold voltage from 3.5 to 1.7 V sub rms.
PRESIDENTIAL GUEST LECTURE: Tribology of Alternative Bearings (2006)

The tribological performance and biological activity of the wear debris produced has been compared for highly cross-linked polyethylene, ceramic-on-ceramic, metal-on-metal, and modified metal bearings in a series of in vitro studies from a single laboratory. The functional lifetime demand of young and active patients is 10-fold greater than the estimated functional lifetime of traditional polyethylene. There is considerable interest in using larger diameter heads in these high demand patients. Highly cross-linked polyethylene show a four-fold reduction in functional biological activity. Ceramic-on-ceramic bearings have the lowest wear rates and least reactive wear debris. The functional biological activity is 20-fold lower than with highly cross-linked polyethylene. Hence, ceramic-on-ceramic bearings address the tribological lifetime demand of highly active patients. Metal-on-metal bearings have substantially lower wear rates than highly cross-linked polyethylene and wear decreases with head diameter. Bedding in wear is also lower with reduced radial clearance. Differential hardness ceramic-on-metal bearings and the application of ceramic-like coatings reduce metal wear and ion levels.
Spin coating over topography (1993)

A model for predicting film thickness profiles around topographical features during spin coating is presented. This model is applicable to features of arbitrary geometry in the two lateral dimensions. This generally permits study of the planarization of real device structures, including both isolated and neighboring features, with any orientation with respect to the wafer center. Predictions from this model agree qualitatively with measured thin-film profiles from interferograms taken during spinning. Phenomena such as pile-up and wakes result from interactions between surface tension and other driving forces in the flow.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Location-based activity recognition with hierarchical dirichlet process (2016)

We consider the problem of analyzing people's mobility and movement patterns from their location history, gathered by mobile devices. Human mobility traces can be extremely complex and unpredictable, by nature, which makes it hard to construct accurate models of mobility behavior. In this work, we present a novel high-level strategy for mobility data analysis based on Hierarchical Dirichlet process, which is a powerful probabilistic model for clustering grouped data. We evaluate our unsupervised approach on two real-world datasets.
Marked Induction of Calcium-Independent Nitric Oxide Synthase Activity after Focal Cerebral Ischemia (1995)

We studied the effect of focal cerebral ischemia on inducible (iNOS) and constitutive (cNOS) nitric oxide synthase enzymatic activities in the affected brain. The middle cerebral artery (MCA) was occluded in spontaneously hypertensive rats. Animals were killed 1, 2, 4, and 7 days later. cNOS and iNOS enzymatic activities were determined in the infarcted cortex using the assay of Bredt and Snyder. cNOS was assayed in the presence of calcium, whereas iNOS was assayed in the absence of calcium and in the presence of tetrahydrobiopterin. The validity of the iNOS assay was verified in rats treated with bacterial lipopolysaccharide. In these animals, the magnitude of the induction of iNOS enzymatic activity in lung, spleen, and brain paralleled the expression of iNOS mRNA, assessed by reverse-transcription polymerase chain reaction. After MCA occlusion, calcium-dependent (cNOS) activity was markedly reduced only in lesioned cerebral cortex at days 1–7 ( p < 0.001; analysis of variance and Tukey's test). In contrast to cNOS, calcium-independent (iNOS) activity was induced substantially in the infarct ( p < 0.005) but not in the contralateral intact cortex ( p > 0.05). iNOS activity peaked at day 2 and was not different from baseline at day 7 ( p > 0.05). No NADPH diaphorase-positive neurons were observed in the area of the lesion at days 1–7. Macrophages appeared at day 2 and invaded the infarcted tissue by day 7. At this time, numerous glial fibrillary acidic protein-positive astrocytes were observed within the lesion. The results suggest that the decline in calcium-dependent (cNOS) activity reflects loss of NOS neurons within the lesion. The induction of calcium-independent activity is likely to reflect induction of iNOS in nonneuronal cells. Sustained nitric oxide production by iNOS may contribute to the late phase of tissue damage in focal cerebral ischemia.
How The Dearfoams® Slipper Company Regained Its Footing (2007)

After substantial losses during 1999–2002, the financial condition of R. G. Barry Corporation reached a crisis stage in 2003 when it exceeded the limits of its line of credit and experienced a net loss of over $21 million. The Meridian Group was engaged in early January 2004 to assist the company in developing a credible turnaround plan and in finding a new lender. Meridian quickly identified that a drastic change to the company9s business model was necessary. Based on the aggressive restructuring plan, Meridian was able to refinance Barry9s borrowing needs with a new lender by the end of March, and Tom Von Lehman of Meridian was appointed interim CEO to execute the turnaround plan. The restructuring plan yielded a dramatic turnaround with the company reporting a net profit of over $8 million in 2005. For the outstanding results obtained in the Barry turnaround, Margaret Good and Thomas Von Lehman were recognized with the 2006 Turnaround of the Year Award—Mid-Sized Company by the Turnaround Management Association. <b>TOPICS:</b>Private equity, performance measurement, portfolio construction, financial crises and financial market history
Ventilator-Induced Lung Injury and Recommendations for Mechanical Ventilation of Patients with ARDS (2001)

Mechanical ventilation is life sustaining and is the standard therapy for acute respiratory failure. The 16th century anatomist Vesalius is often credited for the earliest account of positive-pressure ventilation. In his work De humani corporis fabrica (On the Fabric of the Human Body), he described how an animal could be resuscitated by blowing into a reed inserted into a hole in its trachea. Although positive pressure ventilation using bellows was first used for drowning victims in the 1700s, there were soon concerns that such therapy could in fact be harmful to the lungs. In 1827, Leroy d'Etoille condemned bellows ventilation after discovering that it could lead to emphysema and tension pneumothoraces. Subsequently, positive pressure ventilation would be virtually abandoned for over 100 years. Despite this early concern about the potential for harm from mechanical ventilation, it is only in the last one to two decades that research into so-called ventilator-induced lung injury (VILI) has blossomed. Indeed, although initial studies have focused on which ventilatory parameters are associated with the most (or least) harm, there has been an explosion of research in the last 5 years attempting to delineate the basic cellular mechanisms by which mechanical ventilation injures the lung. Recently, there has been exciting evidence to suggest that lung injury induced by mechanical ventilation may have important systemic consequences, including multi-organ dysfunction. Lastly and most importantly, there is accumulating data from clinical trials in humans that ventilatory strategies designed to avoid VILI can in fact save lives.
A DSP based controller for high-power interleaved boost converters (2003)

High power boost converter has become the essential part of the distributed power system that enables energy to be fully utilized in fuel cell powered electric vehicles and stationary power systems. This paper presents a DSP-based fully digital control implementation for an interleaved high power DC-DC boost converter. A dual-loop average current mode current control method is employed to achieve the fast transient response. Different anti-wind up schemes for a typical PI-controller are evaluated through simulations and experiments. Simulation and experiment results of the 20-kW boost converter under a start-up condition and load transient condition are also presented. The results show that this typical controller with proper anti-wind up scheme achieves a better transient performance than without the anti-wind up scheme.
Bis(ferrocenyl)polymethine Cations. A Prototype Molecular Wire with Redox-Active End Groups (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBis(ferrocenyl)polymethine Cations. A Prototype Molecular Wire with Redox-Active End GroupsLaren M. Tolbert, Xiaodong Zhao, Youzhen Ding, and Lawrence A. BottomleyCite this: J. Am. Chem. Soc. 1995, 117, 51, 12891–12892Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/ja00156a040https://doi.org/10.1021/ja00156a040research-articleACS PublicationsRequest reuse permissionsArticle Views218Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts