gebhart/patrepeval huggingface dataset:
Quantum Computing with Neutral Atoms in an Optical Lattice (2000)

We present a proposal for quantum information processing with neutral atoms\ntrapped in optical lattices as qubits. Initialization and coherent control of\nsingle qubits can be achieved with standard laser cooling and spectroscopic\ntechniques. We consider entangling two-qubit logic gates based on optically\ninduced dipole-dipole interactions, calculating a figure-of-merit for various\nprotocols. Massive parallelism intrinsic to the lattice geometry makes this an\nintriguing system for scalable, fault-tolerant quantum computation.\n
Visual sensitivity guided bit allocation for video coding (2006)

A video bit allocation technique adopting a visual distortion sensitivity model for better rate-visual distortion coding control is proposed in this paper. Instead of applying complicated semantic understanding, the proposed automatic distortion sensitivity analysis process analyzes both the motion and the texture structures in the video sequences in order to achieve better bit allocation for rate-constrained video coding. The proposed technique evaluates the perceptual distortion sensitivity on a macroblock basis, and allocates fewer bits to regions permitting large perceptual distortions for rate reduction. The proposed algorithm can be incorporated into existing video coding rate control schemes to achieve same visual quality at reduced bitrate. Experiments based on H.264 JM7.6 show that this technique achieves bit-rate saving of up to 40.61%. However, the conducted subjective viewing experiments show that there is no perceptual quality degradation. EDICS-1-CPRS, 3-QUAL.
<b>Characterization of a <i>Penicillium chrysogenum</i> gene encoding a PacC transcription factor and its binding sites in the divergent <i>pcbAB–pcbC</i> promoter of the penicillin biosynthetic cluster</b> (1996)

Previous work established that pH regulation of gene expression in Aspergillus nidulans, a major determinant of penicillin biosynthesis, is mediated by the zinc-finger transcription factor PacC, an activator of transcription of the isopenicillin N synthase gene. We characterize here the pacC gene from the efficient penicillin producer Penicillium chrysogenum, which functionally complements an A. nidulans pacC null mutation. It encodes a 641-residue polypeptide showing 64% identify to A. nidulans PacC and containing three putative zinc fingers specifically recognizing a 5'-GCCARG-3' hexanucleotide. Penicillium pacC transcript levels are higher under alkaline than under acidic growth conditions and elevate at late stages of growth. The gene contains three PacC-binding sites in its 5'-upstream region. Transcript levels of pcbC (encoding P. chrysogenum isopenicillin N synthase) are low on a repressing carbon source and elevated on a derepressing carbon source. With either carbon source, alkaline pH elevates pcbC transcript levels, correlating with the presence of seven PacC-binding sites in the 1.1 kb pcbAB-pcbC intergenic region and strongly suggesting that pcbC is under direct pacC control. However, in contrast to the situation in A. nidulans, alkaline pH does not override the negative effects of a repressing carbon source, revealing differences in the regulation of the penicillin pathway between Penicillium and Aspergillus.
Chronic giardiasis: studies on drug sensitivity, toxin production, and host immune response. (1982)

(a) The chronicity of our patient's infection was not due to the organism having unique properties of drug resistance. (b) Combined quinacrine and metronidazole, which cured our patient's chronic giardiasis, should be tried in patients in whom infection persists after single drug therapy. (c) The diarrhea in our patient was probably caused by a mechanism other than Giardia lamblia-induced secretion by currently recognized enterotoxins. (d) Reduced cellular cytotoxicity for Giardia lamblia may have contributed to the persistence of our patient's infection and should be suspected in other patients with chronic giardiasis.
A Psychological Color Solid* (1943)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Dorothy Nickerson and Sidney M. Newhall, "A Psychological Color Solid*," J. Opt. Soc. Am. 33, 419-422 (1943) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Decreased expression of complement regulatory proteins, CD55 and CD59, on peripheral blood leucocytes in patients with type 2 diabetes and macrovascular diseases. (2009)

CD55 and CD59 expressions on peripheral blood leucocytes are decreased in T2DM patients with macrovascular diseases. The results suggest that the decreased levels of complement regulatory proteins might play an important role in diabetic macrovascular diseases.
Round-trip engineering of eclipse plug-ins using eclipse workbench part interaction FSML (2006)

A Framework-Specific Modeling Language (FSML) is a kind of Domain-Specific Modeling Language that is used for modeling framework-based software. FSMLs enable automated round-trip engineering over non-trivial model-to-code mappings and thereby simplify the task of creating and evolving framework-based applications. In this demonstration, we present a prototype implementation of Eclipse Workbench Part Interaction, a FSML capturing an aspect of Eclipse plug-in development. We walk through an example Eclipse plug-in development scenario and demonstrate the round-trip engineering capabilities of the prototype.
Adapter Protein SH2-Bβ Undergoes Nucleocytoplasmic Shuttling: Implications for Nerve Growth Factor Induction of Neuronal Differentiation (2004)

The adapter protein SH2-B has been shown to bind to activated nerve growth factor (NGF) receptor TrkA and has been implicated in NGF-induced neuronal differentiation and the survival of sympathetic neurons. However, the mechanism by which SH2-B enhances and maintains neurite outgrowth is unclear. We examined the ability of truncation mutants to regulate neuronal differentiation and observed that certain truncation mutants localized in the nucleus rather than in the cytoplasm or at the plasma membrane as reported for wild-type SH2-B beta. Addition of the nuclear export inhibitor leptomycin B caused both overexpressed wild-type and endogenous SH2-B beta to accumulate in the nucleus of both PC12 cells and COS-7 cells as did deletion of a putative nuclear export sequence (amino acids 224 to 233) or mutation of two critical lysines in that sequence. Deleting or mutating the nuclear export signal caused SH2-B beta to lose its ability to enhance NGF-induced differentiation of PC12 cells. Neither the NGF-induced phosphorylation of ERKs 1 and 2 nor their subcellular distribution was altered in PC12 cells stably expressing the nuclear export-defective SH2-B beta(L231A, L233A). These data provide strong evidence that SH2-B beta shuttles constitutively between the nucleus and cytoplasm. However, SH2-B beta needs continuous access to the cytoplasm and/or plasma membrane to participate in NGF-induced neurite outgrowth. These data also suggest that the stimulatory effect of SH2-B beta on NGF-induced neurite outgrowth of PC12 cells is either downstream of ERKs or via some other pathway yet to be identified.
Basal Nitric Oxide Production is Not Reduced in Patients with Noninsulin-Dependent Diabetes Mellitus (1997)

Vascular disease is the leading cause of morbidity, disability and death in patients with noninsulin-dependent diabetes mellitus. Abnormalities in endothelium-derived nitric oxide (NO) have been demonstrated to be involved in the pathogenesis of vascular disease. By measuring hemodynamic responses to a NO synthase agonist or antagonist, previous studies have shown the presence of NO deficiency in patients with noninsulin-dependent diabetes mellitus, a method of assessing bioactive NO formation. However, direct biochemical evidence that this is the case, has not been produced. In vivo NO is metabolized into nitrate, an end breakdown product of NO, which can be used as an index of endogenous NO formation. To investigate further whether decreased basal synthesis of NO may be a major cause of endothelium-mediated vascular dysfunction in patients with noninsulin-dependent diabetes mellitus, the plasma nitrite/nitrate levels of 15 patients were examined and compared with 13 normal controls. The results showed that in basal conditions plasma nitrite/nitrate levels were not reduced in diabetic patients compared with normal controls (37.3 +/- 14.7 versus 29.4 +/- 8.6 mumol/l). It was concluded that in noninsulin-dependent diabetes mellitus patients, endothelium-derived basal NO formation is not impaired. This study, taken with previous observations, suggests that factors other than diminished basal NO production, such as reduced bioavailability of NO probably due to the augmented production of superoxide anion with subsequently increased inactivation of NO, contribute to the high incidence of vascular disease in patients with noninsulin-dependent diabetes mellitus.
Fast-flow pulsed CO<sub>2</sub>closed-cycle laser with a carbon dioxide regeneration unit (1981)

Stabilization of the output energy and composition of the mixture in a pulse-periodic CO2 laser was achieved by regenerating carbon dioxide with a palladium catalyst. Measurements of the small-signal gain of mixtures with different compositions demonstrated that the reduction in the gain on dissociation of CO2 was due to a reduction in the CO2 concentration and an increase in the concentrations of CO and O2.
Screening for EGFR and KRAS mutations in non-small cell lung carcinomas using DNA extraction by hydrothermal pressure coupled with PCR-based direct sequencing. (2013)

EGFR and KRAS mutations correlate with response to tyrosine kinase inhibitors in patients with non-small cell lung carcinoma (NSCLC). We reported a hydrothermal pressure method of simultaneous deparaffinization and lysis of formalin-fixed paraffin embedded (FFPE) tissue followed by conventional chaotropic salt column purification to obtain high quality DNA for mutation analysis using PCR-base direct sequencing. This study assessed the feasibility of using this method to screen for exons 18-21 of EGFR and exon 2 of KRAS gene mutations in surgical resection and core needle biopsy specimens from 251 NSCLC patients. EGFR mutations were identified in 140 (55.8%) NSCLC patients (118 in adenocarcinoma, 11 in squamous cell carcinoma, 7 in adenocarcinoma and 4 in NSCLC-not otherwise specified), including four novel substitutions (L718M, A743V, L815P, V819E). EGFR mutations were frequently present in female patients (72 of 113, 63.7%) and NSCLC with adenocarcinoma component (125/204, 61.3%) with statistical significance. Twenty-one patients had multiple mutations at different exons of EGFR, in which seventeen patients had deletions in exon 19. KRAS mutations were found in 18 (7.2%) patients (15 in adenocarcinoma, 2 in squamous cell carcinoma and one in NSCLC-not otherwise specified), including an uncommon substitution G13C. Deparaffinization and lysis by hydrothermal pressure, coupled with purification and PCR-based sequencing, provides a robust screening approach for EGFR and KRAS mutation analysis of FFPE tissues from either surgical resection or core needle biopsy in clinical personalized management of lung cancer.
Proteolytic processing of presecretory proteins is required for development of biological activities in pancreatic exocrine proteins. (1983)

The biological activities of pancreatic presecretory and secretory proteins synthesized in vitro were compared in studies of (a) the binding of nascent amylase to its substrate, glycogen, (b) the binding of nascent trypsinogen 1, trypsinogen 2+3, and chymotrypsinogen 1 to Sepharose-bound soybean trypsin inhibitor, and (c) the activation of nascent trypsinogen by porcine enterokinase. Nascent secretory proteins synthesized in vitro using a mRNA-dependent gel-filtered reticulocyte lysate translation system supplemented with canine pancreas rough microsomes or canine pancreas mRNA and micrococcal nuclease-treated microsomal membranes showed biological activities similar to authentic secretory proteins if oxidized glutathione was added during their synthesis. Proteins synthesized in the presence of membranes and the absence of glutathione showed significantly less biological activity due to incorrect development of conformation. Presecretory proteins synthesized in vitro with canine pancreas mRNA in the absence of microsomal membranes had little or no activity after translation in either the absence or presence of glutathione. These and previous findings (Scheele, G. A., and Jacoby, R. (1982) J. Biol. Chem. 257, 12277-12282) indicate that proteolytic removal of the NH2-terminal transport peptide is necessary to allow correct conformational development, including the formation of native disulfide bonds, which not only stabilizes the molecule but allows expression of authentic biological and probiological activity.
[Metabolism of fluorine in terminal renal failure]. (1986)

Report on a 76-year-old man with untreated terminal renal insufficiency and fluoride load lasting for decades. We found the typical constellation of low fluoride values in the urine, very high serum values and considerable storage of fluoride in the skeleton. With regard to the fluoridation of drinking water fluorides are a remarkable factor in the care of patients with chronic renal diseases.
Douglas-Fir Tussock Moth Control on Douglas-Fir, 1976 (1977)

Abstract The test was done on epidemic Douglas-fir tussock moth populations near Kamloops, B.C. Dimilin was applied in a randomized block design by using a conventional boom and nozzle system on fixed-wing aircraft with 22 evenly-spaced tee-Jet nozzles and no. 8010 flat fan spray tips. A mixture of 90% water and 10% ethylene glycol served as carrier. The formulation was sprayed at the rate of 1 gal/acre at 110 mph and 40 psi. The 12 plots ranged in size from 50 to 81 acres and in elevation from 2300 to 2900 ft . Treatments were replicated 3 times and each was applied on June 13, 17, and 18 after complete egg hatch and larval dispersal. Orgyia pseudotsugata larvae were counted on 2 mid crown branch samples from 25 trees in each plot on the day before spray, and 7, 14, 2 1 , 28, and 35 days after spraying. Data were transformed to larvae/1000 in2 of Douglas-fir foliage and subjected to analysis of variance and analysis of covariance.
Flexible service provision considering specific customer resource needs (2003)

The development of global networks like the Internet has opened new possibilities for the co-operation of various organisations. A computing resource can be offered by one organisation and it can be remotely used by customers, i.e. other organisations or individuals, to perform some task or access some service on it. Such a resource not only has to be provided for a suitable price but, additionally, it has to be deployed in an efficient way, promising a good performance in service provision to satisfy the customers. Because existing infrastructures have to be integrated and used in the service provision process, it becomes necessary to develop new concepts for the management of the arising service-oriented distributed systems and the resources involved. This paper discusses a mechanism for the performance management of services in distributed environments. A service trader is used as a central component, supporting a customer in choosing a suitable service while considering the global state of the distributed system's resources using a load balancer. Management proxies encapsulate services or service groups and observe the performance and availability characteristics of the resources involved in a service usage process to fulfil the quality characteristics of a mediated service. This approach is designed to cause minimal involvement of service providers and customers in the selection and management process.
Multiple Ascending Dose Safety, Tolerability, and Pharmacokinetics of KBP-7072, a Novel Third-generation Tetracycline (2017)

KBP-7072 is a novel aminomethylcycline exhibiting broad-spectrum activity against Gram+ and Gram- multidrug-resistant bacterial isolates and strains. KBP-7072 has previously been studied in a single ascending dose study up to 300 mg in healthy adults. This was a randomized, single-blind, placebo-controlled, sequential parallel-group, multiple ascending dose study to evaluate the safety, tolerability, and pharmacokinetics (PK) of KBP-7072 in healthy adults. Four cohorts were planned with 8 subjects (6 KBP-7072, 2 placebo) in each cohort to evaluate KBP-7072 100 mg QD, 200 mg QD, 300 mg QD, and 200 mg BID for 10 days. Dose escalation stopped following completion of the 200 mg QD cohort. Safety, tolerability, and PK were evaluated for each cohort. 16 subjects (male: 87.5%; 18–55 years of age) were enrolled including 8 in each of the 2 dose escalation cohorts (100 mg QD and 200 mg QD). After the results of the first two cohorts (100 mg QD and 200 mg QD) were analyzed, it was determined that the therapeutic dose of KBP-7072 was likely to be less than 200 mg/day. All treatment-emergent adverse events (TEAEs) were of mild intensity, resolved without intervention, and most TEAEs were assessed as either unrelated or probably unrelated to treatment. No serious adverse events were reported. Elevated alanine aminotransferase was reported in 4 subjects (all in the 200 mg QD cohort) who were asymptomatic and recovered without intervention. PK data included in the table below suggests that exposure is approximately dose proportional. KBP-7072 Plasma PK Parameters by Treatment at Day 10 – PK Population KBP-7072 Plasma PK Parameters by Treatment at Day 10 – PK Population This study demonstrated that KBP-7072 was safe and generally well-tolerated at doses up to and including 200 mg QD. F. Yang, KBP Biosciences Co., Ltd.: Employee, Salary. Y. Wang, KBP Biosciences USA Inc.: Employee, Salary. P. Wang, KBP Biosciences Co., Ltd.: Employee, Salary. M. Hong, KBP Biosciences: Employee, Salary. V. Benn, KBP Biosciences USA Inc.: Employee, Salary.
Neurogenesis in the Adult Brain: New Strategies for Central Nervous System Diseases (2004)

New cells are continuously generated from immature proliferating cells throughout adulthood in many organs, thereby contributing to the integrity of the tissue under physiological conditions and to repair following injury. In contrast, repair mechanisms in the adult central nervous system (CNS) have long been thought to be very limited. However, recent findings have clearly demonstrated that in restricted areas of the mammalian brain, new functional neurons are constantly generated from neural stem cells throughout life. Moreover, stem cells with the potential to give rise to new neurons reside in many different regions of the adult CNS. These findings raise the possibility that endogenous neural stem cells can be mobilized to replace dying neurons in neurodegenerative diseases. Indeed, recent reports have provided evidence that, in some injury models, limited neuronal replacement occurs in the CNS. Here, we summarize our current understanding of the mechanisms controlling adult neurogenesis and discuss their implications for the development of new strategies for the treatment of neurodegenerative diseases.
RODA: a new dynamic routing protocol using dual paths to support asymmetric links in mobile ad hoc networks (2002)

The existing routing protocols in mobile ad hoc networks assume that all the nodes have the same transmission range. In other words, the mobile ad hoc network has only symmetric links, which means that two neighboring nodes A and B are within the transmission range of one another. However, since nodes consume battery power independently according to their computing and communication load, there exist asymmetric links, which means that node A is within node B's transmission range, but not vice versa. In this paper, to cope with asymmetric links, a new routing protocol based on source-initiated on-demand routing (called RODA-routing protocol with dual paths to support asymmetric links) is presented. In order to perform route maintenance in an efficient manner, dual paths-forward (source to receiver) and backward (receiver to source) paths-are used to send and receive data packets. In addition, a timer mechanism is introduced to deal with simultaneous and consecutive broken links on both forward and backward paths. Simulation results reveal that RODA copes well with an ad hoc network having asymmetric wireless links under the presence of mobility.
Submillimeter spectroscopy for chemical analysis with absolute specificity (2010)

A sensor based on rotational signatures in the submillimeter (SMM) region is described. This sensor uses frequency synthesis techniques in the region around 10 GHz, with nonlinear diode frequency multiplication to 210-270 GHz. This provides not only a nearly ideal instrument function, but also frequency control and agility that significantly enhance the performance of the spectrometer as a sensor. The SMM frequencies provide significantly stronger absorptions and broader spectroscopic coverage than lower-frequency microwave systems. Among the characteristics of the sensor are absolute specificity, low atmospheric clutter, good sensitivity, and near-term paths to systems that are both compact and very inexpensive.
Succession: Measuring transfer of code and developer productivity (2009)

Code ownership transfer or succession is a crucial ingredient in open source code reuse and in offshoring projects. Measuring succession can help understand factors that affect the success of such transfers and suggest ways to make them more efficient. We propose and evaluate several methods to measure succession based on the chronology and traces of developer activities. Using ten instances of offshoring succession identified through interviews, we find that the best succession measure can accurately pinpoint the most likely mentors. We model the productivity ratio of more than 1000 developer pairs involved in the succession to test conjectures formulated using the organizational socialization theory and find the ratio to decrease for instances of offshoring and for mentors who have worked primarily on a single project or have transferred ownership for their non-primary project code, thus supporting a theory-based conjectures and providing practical suggestions on how to improve succession.