gebhart/patrepeval huggingface dataset:
Interactive graphics intersection design user's manual (1994)

The Interactive Graphics Intersection Design System (IGIDS) has been developed at the Center for Transportation Research at the University of Texas at Austin in cooperation with the Texas Department of Transportation and the Federal Highway Administration. IGIDS is a package of drawing, analysis, and data manipulation tools for use by the designer of street intersections. These tools are aids to the designer in reviewing and revising existing designs or in the design of new intersections. This report serves as the IGIDS reference manual. It describes the structure of the IGIDS database and contains descriptions of each IGIDS command.
Genetic rearrangements and gene amplification in Escherichia coli: DNA sequences at the junctures of amplified gene fusions. (1987)

We describe gene fusions that result from genetic duplications of 5-20 kb, which are amplified 50- to 100-fold. Because one end point of the fusion lies within the sequenced lacI gene, the new junctures created by the duplications are readily identified. Using a procedure for dideoxy sequencing of double-stranded DNA, we show that the duplications occur almost exclusively at short sequence repeats (less than 15 bp), sometimes involving broken homologies, in the 30 cases examined. Most of the duplications place the lacI-Z encoded hybrid repressor-beta-galactosidase protein under the control of a downstream promoter, resulting in the production of a more complex hybrid protein with beta-galactosidase activity. In some cases the fusion occurs with the lacY or the lacA gene, which suggests that silent promoters can be uncovered by gene fusion and subsequent amplification. In some ways this system represents a bacterial analog to chromosomal rearrangements of oncogenes in higher cells, since here the expression of a silent gene is the result of a genetic rearrangement that is followed by amplification during selected growth.
Improved small multiplier based multiplication, squaring and division (2003)

This paper presents the design of parameterized fixed-point integer multiplication, squaring and fractional division units. The units are targeted at the Virtex-II family of FPGAs (field programmable gate arrays) from Xilinx and are based on the small 18X18-bit multiplier blocks. New partial product creation and summation techniques that exploit the low level primitives are used that achieve a 20% area and a 30% delay reduction for multiplication. A dedicated squaring component is presented that offers substantial area savings of up to 50%. The division component uses the multipliers for pre-scaling to reduce the delay and complexity of each minimally redundant radix-8 stage.
Intense Transillumination for Infant Venipuncture (1975)

Transillumination of an extremity during venipuncture in infants or obese children is described. Transillumination facilitates accurate placement of the needle tip within the vein.
Models and Methods in Social Network Analysis (2005)

Models and Methods in Social Network Analysis, first published in 2005, presents the most important developments in quantitative models and methods for analyzing social network data that have appeared during the 1990s. Intended as a complement to Wasserman and Faust's Social Network Analysis: Methods and Applications, it is a collection of articles by leading methodologists reviewing advances in their particular areas of network methods. Reviewed are advances in network measurement, network sampling, the analysis of centrality, positional analysis or blockmodelling, the analysis of diffusion through networks, the analysis of affiliation or 'two-mode' networks, the theory of random graphs, dependence graphs, exponential families of random graphs, the analysis of longitudinal network data, graphical techniques for exploring network data, and software for the analysis of social networks.
Larvicidal Efficacy ofBacillus thuringiensisSerotype H-14 Against Stagnant-Water Mosquitoes and Its Effects on Nontarget Organisms (1982)

Journal Article Larvicidal Efficacy of Bacillus thuringiensis Serotype H-14 Against Stagnant-Water Mosquitoes and Its Effects on Nontarget Organisms Get access Mir S. Mulla, Mir S. Mulla Department of Entomology, University of California, Riverside, California 92521 Search for other works by this author on: Oxford Academic PubMed Google Scholar Brian A. Federici, Brian A. Federici Department of Entomology, University of California, Riverside, California 92521 Search for other works by this author on: Oxford Academic PubMed Google Scholar Husam A. Darwazeh Husam A. Darwazeh Department of Entomology, University of California, Riverside, California 92521 Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 11, Issue 4, 1 August 1982, Pages 788–795, https://doi.org/10.1093/ee/11.4.788 Published: 01 August 1982 Article history Received: 04 August 1981 Published: 01 August 1982
Encoding multimedia presentations for user preferences and limited environments (2003)

This paper discusses a new approach of generating TV-like multimedia presentations that are adapted to the target user preferences and to limited devices. Three main points are discussed: 1) the encoding of video presentations from a SMIL specification, 2) the adaptation of the video content based on the user preferences, and 3) the delivery of adapted multimedia presentations. The used architecture includes a content server, an adaptation proxy and a set of small devices in the form of personal device assistants (PDA). These devices request the content through a wireless network. In order to show how the system behaves regarding the user preferences and capabilities, two negotiation dimensions are considered: the user language and the memory capability of the device. The first dimension is used to generate a content that can be understood by the target user, e.g. a video with subtitles written in the preferred language. The second dimension is chosen to solve the problem of the system blocking that usually happens when limited devices access rich multimedia presentations over the network.
Constrained K-Means Clustering (2000)

The ion form as calcium bicarbonate appeared to be most favourable for the correction of mineral distillate content with various calcium compounds. An organocomplex compound--calcium lactate can not be considered as an adequate model for the scientific substantiation of hygienic standards for calcium content in drinking water. Completely demineralized water consumed perorally gives a negative embryotropic effect.
Use of Phthaloyl Protecting Group for the Automated Synthesis of 3'-[(Hydroxypropyl)amino] and 3'-[(Hydroxypropyltriglycyl] Oligonucleotide Conjugates (1995)

The chemical stability of oligonucleotides (ODNs) containing 3'-propanolamine was investigated. Invariably, all the ODNs synthesized from Fmoc-protected 3-aminopropane-1,2-diol-CPG support gave a mixture of three compounds at the end of automated synthesis as analyzed by denaturing PAGE and HPLC. On the basis of analytical procedures, these compounds were identified to be 3'-[N-acetyl-N-(hydroxypropyl)amino],3'-[(hydroxypropyl)amino], and 3'-hydroxyl ODNs. The instability of the amino protecting group under the synthesis conditions was responsible for this observed heterogeneity. In order to evaluate the stability, a comparative study on the chemical stability of the ODN containing amino-protecting groups such as [(9-fluorenylmethyl)oxy]carbonyl (Fmoc), trifluoroacetyl (TFA), and phthaloyl was undertaken. The results indicate that the phthaloyl group provided the best stability for the synthesis of 3' amine-modified ODNs, and the protecting group is cleaved and deprotected in concentrated ammonium hydroxide:40% aqueous methylamine, 1:1, for 5-10 min, at 56 degrees C. The 3'-hydroxypropyl)triglycyl] ODN conjugates were also synthesized from Fmoc- and phthaloyl-protected (hydroxypropyl)triglycine-CPG supports.
Clinical Relevance of Thiamine Status amongst Hospitalized Elderly Patients (1999)

Severe thiamine deficiency remained quite low among the hospitalized elderly. The prevalence of moderate thiamine deficiency approached 40%. Institutionalized subjects were at particular risk of developing thiamine deficiency. Its clinical relevance on functional status and on cognitive function remained not significant. By contrast, a high proportion of falls, Alzheimer's disease, depression, cardiac failure and furosemide use could have been related to thiamine deficiency.
Soft Polymers for Building up Small and Smallest Blood Supplying Systems by Stereolithography (2012)

Synthesis of a homologous series of photo-polymerizable α,w-polytetrahydrofuranether-diacrylate (PTHF-DA) resins is described with characterization by NMR, GPC, DSC, soaking and rheometrical measurements. The curing speeds of the resins are determined under UV light exposure. Young's modulus and tensile strength of fully cured resins show flexible to soft material attributes dependent on the molar mass of the used linear PTHF-diacrylates. Structuring the materials by stereo lithography (SL) and multiphoton polymerization (MPP) leads to tubes and bifurcated tube systems with a diameter smaller than 2 mm aimed at small to smallest supplying systems with capillary dimensions. WST-1 biocompatibility tests ofm polymer extracts show nontoxic characteristics of the adapted polymers after a washing process. Some polymers show shape memory effect (SME).
CD70/CD27 Signaling Mediates Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors By Compensatory Activation of the Wnt Pathway (2014)

Abstract The introduction of BCR/ABL-specific tyrosine kinase inhibitors (TKIs) a decade ago revolutionized chronic myelogenous leukemia (CML) therapy. However, disease-initiating leukemia stem cells (LSCs) in CML are resistant to TKIs despite BCR/ABL inhibition. Therefore, CML will ultimately relapse upon drug discontinuation. We have previously shown that blocking CD70/CD27 signaling targets LSCs by inhibiting the activation of the Wnt pathway. Here, we investigated a combination therapy of TKIs and CD70/CD27 blocking monoclonal antibodies in human and murine CML. We demonstrate that TKI-mediated BCR/ABL inhibition down-regulates miR-29, leading to increased expression of specificity protein 1 (SP1), a transcription factor with binding site in the CD70 promoter. In addition, TKI treatment reduced the expression of DNA methyltransferases resulting in de-methylation of the CD70 promoter. These combined effects resulted in CD70 up-regulation on LSCs, enhanced CD70/CD27 signaling and compensatory Wnt pathway activation. Combined BCR/ABL and CD70/CD27 inhibition synergistically reduced Wnt signaling and eradicated leukemia cells in vitro. More importantly, combination therapy effectively eliminated CD34+ CML stem/progenitor cells in murine xenografts and LSCs in a murine CML model. Therefore, TKI-induced CD70 up-regulation triggers CD70/CD27 signaling leading to compensatory Wnt activation. These findings identify an important targetable TKI resistance mechanism of CML LSCs and may lead to new therapeutic strategies to directly target LSCs to overcome treatment resistance. Disclosures No relevant conflicts of interest to declare.
Discrimination of geophysical phenomena in satellite radar interferograms (1995)

Various geophysical phenomena are recorded in the interference patterns formed by differencing two synthetic aperture radar (SAR) images. The fringes generated by the topographic relief can be removed using a digital elevation model (DEM). The remaining fringes map the change in satellite‐to‐ground range which occurred between the acquisition times of the two images. By comparing different pairs of images spanning different intervals of time, it is possible to discriminate between geophysical signal and interferometric artifact. Here we apply this pair‐wise logic to the area around the 1992 Landers, California earthquake using SAR images acquired by the ERS‐1 satellite. The range varies with time as a constant, step, impulsive, or sloping function. Examples of each type include a DEM error, an aftershock, two atmospheric perturbations, and postseismic afterslip, respectively. Their signatures are identified and separated using the pair‐wise logic.
The Kansei Music System (1989)

Our laboratory in Osaka has been studying pattern recognition techniques, under the direction of Seiji Inokuchi. We have two main research groups: (1) music and acoustics and (2) imaging technology. Our first musical research began in 1978, when we made a simple transcription experiment for database generation with the National Museum of Ethnology Museum in Japan (Nakamura and Inokuchi 1979). Our current music group is composed of five members, and we have been studying music information processing using our knowledge of music and signal processing. Our current main project is the construction of the music system, headed by Haruhiro Katayose. Kansei is a Japanese word that means sense, feeling, emotion, or sensitivity. It is a subjective concept, used in contrast to intelligence. Our goal is to construct a robotic system that can respond to music as a human musician does (Katayose et al. 1988). Musicians can play, write, read, and transform music in their brains into various media if they have some experience. Even if they are not trained musicians, listeners can appreciate music, and some may even compose simple pieces. We want to simulate such processes. The central problem is to make the machine feel music. Note that our goal is not to explain human feeling but to make the machine feel music as a human would.
The Impact of Different Doses of Estrogen and Progestin on Mood and Sexual Behavior in Postmenopausal Women* (1991)

This study investigated the effects of various doses of estrogen and progestin on psychological functioning and sexual behavior of 48 healthy, naturally menopausal women. Subjects were tested before treatment and then randomly assigned to 1 of 4 cyclic sequential hormone regimens for 1 yr. Groups A and C received 0.625 or 1.25 mg conjugated equine estrogen (CEE), respectively, for days 1-25 and 5 mg medroxyprogesterone acetate from days 15-25. Groups B and D were given 0.625 or 1.25 mg CEE, respectively, from days 1-25 and placebo from days 15-25. The higher dose of CEE induced supraphysiological levels of plasma estrone. Plasma testosterone levels were lower in group A when blood was sampled during days 18-20 at a time when they were ingesting both 0.625 mg CEE and 5 mg medroxyprogesterone acetate (P less than 0.05), although these decreases were perhaps too trivial to have affected sexual behavior as was hypothesized. Women in group A also had more negative moods and more psychological symptomatology during treatment compared to those in group D who were receiving 1.25 mg CEE and placebo (P less than 0.01). Regardless of group, sexual desire and arousal were higher during the first 2 weeks of the treatment cycle than during week 4 when no hormones were being ingested (P less than 0.05). These findings demonstrate that the effects of progestin on the central nervous system are reflected by an increase in psychological, exclusive of sexual, symptomatology and are attenuated by a higher estrogen/progestin dose ratio.
Delivery of xenon-containing echogenic liposomes inhibits early brain injury following subarachnoid hemorrhage (2018)

Xenon (Xe), a noble gas, has promising neuroprotective properties with no proven adverse side-effects. We evaluated neuroprotective effects of Xe delivered by Xe-containing echogenic liposomes (Xe-ELIP) via ultrasound-controlled cerebral drug release on early brain injury following subarachnoid hemorrhage (SAH). The Xe-ELIP structure was evaluated by ultrasound imaging, electron microscopy and gas chromatography-mass spectroscopy. Animals were randomly divided into five groups: Sham, SAH, SAH treated with Xe-ELIP, empty ELIP, or Xe-saturated saline. Treatments were administrated intravenously in combination with ultrasound application over the common carotid artery to trigger Xe release from circulating Xe-ELIP. Hematoma development was graded by SAH scaling and quantitated by a colorimetric method. Neurological evaluation and motor behavioral tests were conducted for three days following SAH injury. Ultrasound imaging and electron microscopy demonstrated that Xe-ELIP have a unique two-compartment structure, which allows a two-stage Xe release profile. Xe-ELIP treatment effectively reduced bleeding, improved general neurological function, and alleviated motor function damage in association with reduced apoptotic neuronal death and decreased mortality. Xe-ELIP alleviated early SAH brain injury by inhibiting neuronal death and bleeding. This novel approach provides a noninvasive strategy of therapeutic gas delivery for SAH treatment.
Direct electro-optic sampling of GaAs integrated circuits (1985)

We report the first electro-optic sampling measurements made directly within an integrated circuit. Using the electro-optic effect in GaAs, we have noninvasively probed the internal voltage waveforms of a 2–12 GHz GaAs FET travelling-wave amplifier integrated circuit driven by a microwave signal source.
Human Cytomegalovirus Immediate Early Interaction with Host Nuclear Structures: Definition of an Immediate Transcript Environment (1997)

The development of an induced transcript environment was investigated at the supramolecular level through comparative localization of the human cytomegalovirus immediate early (IE) transcripts and specific nuclear domains shortly after infection. Compact aggregates of IE transcripts form only adjacent to nuclear domain 10 (ND10), and the viral protein IE86 accumulates exclusively juxtaposed to the subpopulation of ND10 with transcripts. The stream of transcripts is funneled from ND10 into the spliceosome assembly factor SC35 domain through the accumulation of IE86 protein, which recruits some components of the basal transcription machinery. Concomitantly the IE72 protein binds to ND10 and later disperses them. The domain containing the zinc finger region of IE72 is essential for this dispersal. Positional analysis of proteins IE86 and IE72, IE transcripts, ND10, the spliceosome assembly factor SC35, and basal transcription factors defines spatially and temporally an immediate transcript environment, the basic components of which exist in the cell before viral infection, providing the structural environment for the virus to usurp.
Sub-pixel registration of moving objects in visible and thermal imagery with adaptive segmentation (2011)

Sub-pixel registration is critical in object tracking and image super-resolution. Motion segmentation algorithms using the gradient can be applied prior to image registration to improve its accuracy and computational runtime. This paper proposes a new segmentation method that is adaptive variation segmentation in the form of local variances taken at different block sizes to be applied to the sum of absolute image differences. In this paper, two motion segmentation and four image registration methods are tested to optimize the registration accuracy in visible and thermal imagery. Two motion segmentation methods, flux tensor and adaptive variation segmentation, are quantitatively tested by comparing calculated regions of movement with accepted areas of motion. Four image registration methods, including two optical flow, feature correspondence, and correlation methods, are tested in two steps: gross shift and sub-pixel shift estimations. Gross shift estimation accuracy is assessed by comparing estimated shifts against a ground truth. Sub-pixel shift estimation accuracy is assessed by simulated, down-sampled images. Evaluations show that the best segmentation results are achieved using either the flux tensor or adaptive segmentation methods. For well-defined objects, feature correspondence and correlation registration produce the most accurate gross shift registrations. For not well-defined objects, the correlation method produces the most accurate gross and sub-pixel shift registration.
Dental postoperative bleeding complications in patients with suspected and documented liver disease (2012)

There were no episodes of postoperative bleeding in patients. The findings suggest that clinicians should not rely solely on an INR value to predict post-procedure bleeding in patients with liver disease.
SEU effect analysis in an open-source router via a distributed fault injection environment (2001)

The paper presents a detailed error analysis and classification of the behavior of an open-source router when affected by Single Event Upsets (SEUs). The experimental results have been gathered on a real communication network, resorting to an ad-hoc Fault Injection system. The injector has been designed to corrupt the router during its normal service and to analyze the SEU injection effects on the overall distributed system. The performed experiments allowed the authors to identify the most critical memory regions and to cluster the router variables according to their impact on system dependability.
Depth from automatic defocusing (2007)

This paper presents a depth recovery method that gives the depth of any scene from its defocused images. The method combines depth from defocusing and depth from automatic focusing techniques. Blur information in defocused images is utilised to measure depth in a way similar to determining depth from automatic focusing but without searching for sharp images of objects. The proposed method does not need special scene illumination and involves only a single camera. Therefore, there are no correspondence, occlusion and intrusive emissions problems. The paper gives experimental results which demonstrate the accuracy of the method.
Characterization of a Distinctive Motif of the Low Molecular Weight Neurotrophin Receptor that Modulates NGF‐mediated Neurite Growth (1996)

The cytoplasmic region of the common neurotrophin receptor (p75(NGFR)) (rat, human, chick) contains a putative membrane-associating domain implicated in intracellular signalling. A peptide (R3) identical to this domain (p75(NGFR) 367-379) and various analogues of this peptide displayed circular dichroism spectra in aqueous and non-polar environments identical to the amphiphilic tetradecapeptide mastoparan (MP) and were internalized by PC12 rat pheochromocytoma cells. The R3 peptide enhanced neurite growth in PC12 cells, embryo chick primary sensory neurons and fetal rat primary sensory neurons in vitro in the presence of sub-saturating concentrations of NGF. Peptide analogues of R3 not faithful to the distance and angular relationships of ionic groups and the putative amphiphilic structure of p75(NGFR)367-379 displayed reduced potency to enhance p75(NGFR) (PC12(nnr5)), had no influence on neurite growth. The R3 peptide had no effects on cell survival, cell binding or uptake of [125]NGF, affinity cross-linking of [125]NGF to p75(NGFR) or trkA monomers and homodimers, of NGF-mediated trkA monomer tyrosine phosphorylation. The studies implicate a role for a highly conserved motif of p75(NGFR) in the downstream modulation of NGF-mediated neurite growth.