gebhart/patrepeval huggingface dataset:
Triangular antenna arrays (1995)

Antenna arrays in an equilateral triangle configuration can simultaneously provide optimum correlation between antennas at almost vertical incidence as well as substantial suppression of low incidence angle interference and high two-dimensional location finding resolution. In all configurations the use of a center antenna is beneficial for all three requirements: test of consistency of phase data over the whole antenna array, indicating single sources for each Doppler line, as well as maximum interference suppression and optimization for the direction finding resolution.
An LSO scintillator array for a PET detector module with depth of interaction measurement (2001)

Presents construction methods and performance results for a production scintillator array of 64 optically isolated, 3 mm/spl times/3 mm/spl times/30 mm sized LSO crystals. This scintillator array has been developed for a PET detector module consisting of the 8/spl times/8 LSO array coupled on one end to a single photomultiplier tube (PMT) and on the opposite end to a 64 pixel array of silicon photodiodes (PD). The PMT provides an accurate timing pulse and initial energy discrimination, the PD identifies the crystal of interaction, the sum provides a total energy signal, and the PD/(PD+PMT) ratio determines the depth of interaction (DOI). Unlike the previous LSO array prototypes, the authors now glue Lumirror reflector material directly onto 4 sides of each crystal to obtain an easily manufactured, mechanically rugged array with the authors' desired depth dependence. With 511 keV excitation, the authors' obtain a total energy signal of 3600 electrons, pulse-height resolution of 25% FWHM, and 6-15 mm FWHM DOI resolution.
Biosynthesis of blasticidin S from L-.alpha.-arginine. Stereochemistry in the arginine-2,3-aminomutase reaction (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiosynthesis of blasticidin S from L-.alpha.-arginine. Stereochemistry in the arginine-2,3-aminomutase reactionP. C. Prabhakaran, Nam Tae. Woo, Peter S. Yorgey, and Steven J. GouldCite this: J. Am. Chem. Soc. 1988, 110, 17, 5785–5791Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/ja00225a033https://doi.org/10.1021/ja00225a033research-articleACS PublicationsRequest reuse permissionsArticle Views662Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Thermally stimulated resonant current in AlGaAs/GaAs triple barrier diodes (1987)

Thermally stimulated resonant current peaks are observed in Al0.4Ga0.6As/GaAs triple barrier diodes. These current peaks are interpreted as resonant tunnelings from the first excited electron subband in the first well to the first excited subband and to the second excited subband in the second well. The activation energies for these resonance peaks are measured. The results imply that in the substrate-side well there is a large amount of excess electrons to compensate the positive charge of silicon atoms segregated into the structure during the growth.
γ‐Butyrolactone‐processable high‐modulus poly(ester imide)s (2011)

Abstract γ‐Butyrolactone (GBL)‐processable high modulus heat‐resistant materials were developed in this work. The polyaddition of an ester‐containing tetracarboxylic dianhydride, i.e. hydroquinone bis(trimellitate anhydride) (TAHQ), and 2,2′‐bis(trifluoromethyl)benzidine (TFMB) in GBL resulted in gelation in the initial reaction stage. The incorporation of a methyl group to TAHQ (M‐TAHQ) allowed polymerization with TFMB in GBL and led to a homogeneous poly(ester imide) (PEsI) precursor solution with a short pot life of 3 days, whereas a simple copolymerization approach using bulky/flexible comonomers to TAHQ/TFMB was less effective. PEsI precursors (PEsAAs) were prepared from TFMB, M‐TAHQ and a minor fraction of 4,4′‐(hexafluoroisopropylidene)diphthalic anhydride (6FDA) or a fluorene‐containing tetracarboxylic dianhydride. These PEsAA systems showed drastically improved GBL solution stability. In particular, the M‐TAHQ(80);6FDA(20)/TFMB copolymer system provided a PEsAA film with a very high light transmittance at 365 nm (>70%). A photosensitive film composed of this matrix resin and diazonaphthoquinone provided a clear positive‐tone pattern by development in a 2.38 wt% tetramethylammonium hydroxide aqueous solution at room temperature with a high dissolution contrast. The thermally cured PEsI film achieved a very high tensile modulus (>5 GPa) as the present target with other desirable properties, i.e. sufficient film flexibility, a relatively low coefficient of thermal expansion, a high T g and low water absorption. The present materials can be promising candidates as novel buffer coat films in semiconductor applications. Copyright © 2011 Society of Chemical Industry
文件同步 我的电脑在“网上” (2009)

正所谓条条大路通罗马，无论是把文件复制到U盘、移动硬盘还是刻录成光碟，都可以起到保护数据安全的作用。此外很多电脑用户也喜欢使用网络硬盘来备份文件。不过网络硬盘最大的不足就是无法像操作电脑磁盘一样管理文件，这样虽保存容易可查找文件就不太方便了。改造大行动正式开始喽一首先就让“我的电脑”也“上网”。
Peptide Self-Assemblies for Drug Delivery (2015)

Peptide amphiphiles (PAs) are novel engineered biomaterials able to self-assemble into supramolecular systems that have shown significant promise in drug delivery across the cell membane and across challenging biological barriers showing promise in the field of brain diseases, regenerative medicine and cancer. PAs are amino-acid block co-polymers, with a peptide backbone composed usually of 8-30 amino acids, a hydrophilic block formed by polar amino acids, a hydrophobic block which usually entails either non-polar or aromatic amino acids and alkyl, acyl or aryl lipidic tails and in some cases a spacer or a conjugated targeting moiety. Finely tuning the balance between the hydrophilic and hydrophobic blocks results in a range of supramolecular structures that are usually stabilised by hydrophobic, electrostatic, β-sheet hydrogen bonds and π-π stacking interactions. In an aqueous environment, the final size, shape and interfacial curvature of the PA is a result of the complex interplay of all these interactions. Lanreotide is the first PA to be licensed for the treatment of acromegaly and neuroendocrine tumours as a hydrogel administered subcutaneously, while a number of other PAs are undergoing preclinical development. This review discusses PAs architecture fundamentals that govern their self-assembly into supramolecular systems for applications in drug delivery.
A new model for multiple-winding transformer (2002)

A new transformer model for a multiple-winding transformer, which describes the leakage phenomenon, is presented. The unique feature of the model is that each parameter in the model corresponds to a physical magnetic flux. The model parameters can be determined by using the finite element tool. The model can also be converted into other forms, such as the /spl pi/-model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Haemodynamic Quantification of Different Provocation Manoeuvres by Simultaneous Measurement of Right and Left Atrial Pressure: Implications for the Echocardiographic Detection of Persistent Foramen Ovale (2001)

The Valsalva manoeuvre might be the most effective test to provoke a right-to-left atrial shunt for the detection of a PFO during echocardiographic examinations.
Effects of Some Natural Flavonoids on Retinal Function Recovery After Ischemic Insult in the Rat (2004)

It was found that the compounds that showed strong increase of ocular blood flow also showed marked increase of retinal function recovery, whereas those that showed poor increase of ocular blood flow also showed poor effects on the retinal function recovery.
Characterization of Thermally Annealed Fluorinated Silicon Dioxide Films Prepared by Liquid-Phase Deposition (2005)

Fluorinated silicon dioxide films were prepared by liquid phase deposition method using hydrosilicofluoric acid and ammonium hydroxide aqua as sources. The quality of fluorinated silicon dioxide films can be improved by N 2 thermal annealing. It is in an attempt to evaluate the feasibility of this material as a candidate for inter-metal dielectrics in ULSIs. The obtained results were the relative dielectric constant of 3.2, and the leakage current density measured at the electric field of 1.5 MV/cm about 1×10 -7 A/cm 2 at the annealing temperature of 350°C. It has potential for inter-metal dielectric applications.
Integrated Linear AC-coupling Circuit for DC-Balanced and Non-Balanced Traffics (2007)

The paper presents a novel fully-integrated AC-coupling circuit with hybrid common-mode voltage generation and baseline-wander compensation. The on-chip generated and dynamically maintained Vcm offers the maximum freedom for circuit optimization. The BLW compensation can deal with wanders immersed in excessive channel-limiting ISI, and imposes `zero' resistive or capacitive loads to the high-speed data line. The high-frequency kick-back noise contamination is also mitigated. The proposed circuit is implemented in 90nm standard CMOS and validated on silicon.
Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas (2016)

<sec><st>Background</st> The eukaryotic initiation factor 4F (eIF4F) complex plays a pivotal role in protein translation initiation; however, its importance in malignant and benign Schwann cell tumors has not been explored, and whether blocking eIF4F function is effective for treating these tumors is not known. </sec> <sec><st>Methods</st> Immunostaining was performed on human malignant peripheral nerve sheath tumors (MPNSTs) and vestibular schwannomas (VSs) for eIF4F components. The role of eIF4A and eIF4E in cell growth was assessed by RNA interference. Various natural compounds were screened for their growth-inhibitory activity. Flow cytometry and Western blotting were performed to characterize the action of silvestrol, and its antitumor activity was verified in orthotopic mouse models. </sec> <sec><st>Results</st> MPNSTs and VSs frequently overexpressed eIF4A, eIF4E, and/or eIF4G. Depletion of eIF4A1, eIF4A2, and eIF4E substantially reduced MPNST cell growth. From screening a panel of plant-derived compounds, the eIF4A inhibitor silvestrol was identified as a leading agent with nanomolar IC<inf>50</inf> values in MPNST and VS cells. Silvestrol induced G<inf>2</inf>/M arrest in both <it>NF1</it>-deficient and <it>NF1</it>-expressing MPNST cells and primary VS cells. Silvestrol consistently decreased the levels of multiple cyclins, Aurora A, and mitogenic kinases AKT and ERKs. Silvestrol treatment dramatically suppressed tumor growth in mouse models for <it>NF1−/− </it> MPNST and <it>Nf2−/− </it> schwannoma. This decreased tumor growth was accompanied by elevated phospho-histone H3 and TUNEL labeling, consistent with G<inf>2</inf>/M arrest and apoptosis in silvestrol-treated tumor cells. </sec> <sec><st>Conclusions</st> The eIF4F complex is a potential therapeutic target in MPNSTs and VS, and silvestrol may be a promising agent for treating these tumors. </sec>
Cs9[(γ-PW10O36)2Ru4O5(OH)(H2O)4], a new all-inorganic, soluble catalyst for the efficient visible-light-driven oxidation of water (2010)

The tetraruthenium-substituted polyoxometalate Cs(9)[(gamma-PW(10)O(36))(2)Ru(4)O(5)(OH)(H(2)O)(4)] was synthesized and structurally, spectroscopically and electrochemically characterized; it was shown to be a catalyst for visible-light-induced water oxidation.
Process/thread migration and checkpointing in heterogeneous distributed systems (2004)

Process/thread migration and checkpointing are indispensable for resource sharing, cycle stealing, and other modes of interaction. To provide a flexible, transparent, and portable solution in heterogeneous environments, we have developed a multi-grained migration/checkpointing package, MigThread, which can migrate/checkpoint multiple threads to different machines or file systems simultaneously, and also perform single coarse-grained process migration/checkpointing. For scalability and portability, computation states are extracted out of their original places and abstracted to the language level. With the user-level stack/heap management, MigThread does not rely on any thread libraries and operating systems. For heterogeneity, a novel data conversion scheme is proposed to analyze data types automatically and convert data only on the receiver side. For safety, MigThread detects and overcomes "unsafe" factors to qualify virtually all C programs for migration/checkpointing. Some performance measurements are given to illustrate its effectiveness.
Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody (2010)

Compared with many well-studied enveloped viruses, herpesviruses use a more sophisticated molecular machinery to induce fusion of viral and cellular membranes during cell invasion. This essential function is carried out by glycoprotein B (gB), a class III viral fusion protein, together with the heterodimer of glycoproteins H and L (gH/gL). In pseudorabies virus (PrV), a porcine herpesvirus, it was shown that gH/gL can be substituted by a chimeric fusion protein gDgH, containing the receptor binding domain (RBD) of glycoprotein D fused to a truncated version of gH lacking its N-terminal domain. We report here the 2.1-Å resolution structure of the core fragment of gH present in this chimera, bound to the Fab fragment of a PrV gH-specific monoclonal antibody. The structure strongly complements the information derived from the recently reported structure of gH/gL from herpes simplex virus type 2 (HSV-2). Together with the structure of Epstein-Barr virus (EBV) gH/gL reported in parallel, it provides insight into potentially functional conserved structural features. One feature is the presence of a syntaxin motif, and the other is an extended "flap" masking a conserved hydrophobic patch in the C-terminal domain, which is closest to the viral membrane. The negative electrostatic surface potential of this domain suggests repulsive interactions with the lipid heads. The structure indicates the possible unmasking of an extended hydrophobic patch by movement of the flap during a receptor-triggered conformational change of gH, exposing a hydrophobic surface to interact with the viral membrane during the fusion process.
Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature (2014)

Elevated mammalian target of rapamycin (mTOR) signaling has been found in Alzheimer's disease (AD) patients and is linked to diabetes and aging, two known risk factors for AD. However, whether hyperactive mTOR plays a role in the cognitive deficits associated with AD remains elusive. Here, we genetically reduced mTOR signaling in the brains of Tg2576 mice, a widely used animal model of AD. We found that suppression of mTOR signaling reduced amyloid-β deposits and rescued memory deficits. Mechanistically, the reduction in mTOR signaling led to an increase in autophagy induction and restored the hippocampal gene expression signature of the Tg2576 mice to wild-type levels. Our results implicate hyperactive mTOR signaling as a previous unidentified signaling pathway underlying gene-expression dysregulation and cognitive deficits in AD. Furthermore, hyperactive mTOR signaling may represent a molecular pathway by which aging contributes to the development of AD.
A Synthetic Cross-Species CD200R1 Agonist Suppresses Inflammatory Immune Responses In Vivo (2018)

Functional aptamers displaying agonistic or antagonistic properties are showing great promise as modulators of immune responses. Here, we report the development of a polyethylene glycol-modified (PEGylated) DNA aptamer as a cross-species (murine and human) CD200R1 agonist that modulates inflammatory responses in vivo. Specifically, DNA aptamers were discovered by performing independent SELEX searches on recombinant murine and human CD200R1. Aptamer motifs identified by next generation sequencing (NGS) were subsequently compared, leading to the discovery of motifs common to both targets. The CD200R1 DNA aptamer CCS13 displayed the highest agonistic activity toward CD200R1 in terms of suppressing the induction of cytotoxic T-lymphocytes (CTLs) in both human and murine allogeneic-mixed lymphocyte cultures (allo-MLCs). A 20-kDa polyethylene glycol (PEG) chain was covalently attached to the 5' end of this aptamer, and the resulting conjugate was shown to block inflammatory responses in murine models of skin graft rejection and house-dust-mite-induced allergic airway inflammation. Importantly, this agonistic aptamer does not suppress CTL induction in 5-day allo-MLCs with responder cells derived from CD200R1<sup>-/-</sup> mice, indicating that its mode of action is directly linked to CD200R1 activation. This study suggests that one can derive agonistic DNA aptamers that can be verified as immuno-modulators in murine models with outcomes potentially translatable to the treatment of human conditions.
Abstract P3-04-12: BreastMark: An integrated approach to mining publically available Transcriptomic Datasets relating to Breast Cancer Outcome (2012)

Abstract Background: Breast cancer is a complex heterogeneous disease for which a substantial resource of transcriptomic data is available. Indeed, gene expression data have facilitated the division of breast cancer into, at least, five molecular subtypes, Luminal A, Luminal B, Her2, Normal-like and Basal. Once identified, breast cancer subtypes can inform clinical decisions surrounding patient treatment and prognosis. It is important to identify patients at risk of developing aggressive disease so as to tailor the level of clinical intervention. Methods: We have developed a user-friendly web-based system to allow the identification and evaluation of genes that are significantly associated with disease progression and survival for breast cancer in general and also with respect to molecular subtype. The underlying algorithm combines gene expression data from multiple DNA microarray experiments and detailed clinical data to correlate outcome with gene expression levels. This algorithm integrates gene expression and survival data from 21 datasets on 10 different microarray platforms corresponding to 20,017 gene sequences across 3,519 samples. Results: We demonstrate the robustness of our approach in comparison to two commercially available prognostic tests in breast cancer. Our algorithm complements these prognostic tests and is consistent with their findings. In addition, BreastMark can act as a powerful reductionist approach to these more complex gene signatures, eliminating superfluous genes, potentially reducing the complexity and cost of these multi-index assays. We also applied the algorithm to examine expression of 58 receptor tyrosine kinases in the basal-like subtype of breast cancer, identifying seven receptor tyrosine kinases associated with poor disease-free survival and/or overall survival in this subtype (EPHA5, FGFR1, FGFR3, VEGFR1, PDGFRβ, ROS, TIE1). A web application for using this algorithm is currently available at http://glados.ucd.ie/BreastMark/index.html. Conclusions: BreastMark is a useful tool for examining putative prognostic markers at the RNA level in breast cancer. The value of this tool will be in the preliminary assessment of putative biomarkers in breast cancer as a whole and within its molecular subtypes. It will be of particular use to clinical and academic research groups with limited bioinformatics facilities. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-04-12.
Endothelial–perivascular cell signaling in vascular development: lessons from knockout mice (1998)

The importance of perivascular-endothelial cell interactions during blood vessel development is discussed in the light of recent findings in platelet-derived growth factor-B, platelet-derived growth factor receptor-beta, angiopoietin-1 and tie-2 knockout mice, which all show deficient development of perivascular cells. The initial formation of networks of endothelial tubes (vasculogenesis) does not seem to depend on the perivascular cells but subsequent vessel remodeling relies on mesenchymal-endothelial short-range signaling. Based on findings in platelet-derived growth factor and platelet-derived growth factor receptor knockout mice, a general model for the role of platelet-derived growth factors in smooth muscle development is proposed.
iCalm: Wearable Sensor and Network Architecture for Wirelessly Communicating and Logging Autonomic Activity (2010)

Widespread use of affective sensing in healthcare applications has been limited due to several practical factors, such as lack of comfortable wearable sensors, lack of wireless standards, and lack of low-power affordable hardware. In this paper, we present a new low-cost, low-power wireless sensor platform implemented using the IEEE 802.15.4 wireless standard, and describe the design of compact wearable sensors for long-term measurement of electrodermal activity, temperature, motor activity, and photoplethysmography. We also illustrate the use of this new technology for continuous long-term monitoring of autonomic nervous system and motion data from active infants, children, and adults. We describe several new applications enabled by this system, discuss two specific wearable designs for the wrist and foot, and present sample data.
R-3 Ferroelectric Memory (1997)

Summary form only given. Ferroelectric memories utilize an electriically polarizable material such as Pb(Zr,Ti)03 or SrBi;!Ta209t o store information in a non-volatile fashion. Recent improvements in the understanding of these materials and associated electrodes allow the possibility of high density memories with multiple (> 1E10) read/write cycles and low voltage (few volts) switching. This discussion section will address two major issues associated with these materials.