gebhart/patrepeval huggingface dataset:
Synthesis and extracellular deposition of fibronectin in chondrocyte cultures. Response to the removal of extracellular cartilage matrix. (1978)

Fibronectin, the major cell surface glycoprotein of fibroblasts, is absent from differentiated cartilage matrix and chondrocytes in situ. However, dissociation of embryonic chick sternal cartilage with collagenase and trypsin, followed by inoculation in vitro reinitiates fibronectin synthesis by chondrocytes. Immunofluorescence microscopy with antibodies prepared against plasma fibronectin (cold insoluble globulin [CIG]) reveals fibronectin associated with the chondrocyte surface. Synthesis and secretion of fibronectin into the medium are shown by anabolic labeling with [35S]methionine or [3H]glycine, and identification of the secreted proteins by immunoprecipitation and sodium dodecyl sulfate (SDS)-disc gel electrophoresis. When chondrocytes are plated onto tissue culture dishes, the pattern of surface-associated fibronectin changes from a patchy into a strandlike appearance. Where epithelioid clones of polygonal chondrocytes develop, only short strands of fibronectin appear preferentially at cellular interfaces. This pattern is observed as long as cells continue to produce type II collagen that fails to precipitate as extracellular collagen fibers for some time in culture. Using the immunofluorescence double-labeling technique, we demonstrate that fibroblasts as well as chondrocytes which synthesize type I collagen and deposit this collagen as extracellular fibers show a different pattern of extracellular fibronectin that codistributes in large parts with collagen fibers. Where chondrocytes begin to accumulate extracellular cartilage matrix, fibronectin strands disappear. From these observations, we conclude (a) that chondrocytes synthesize fibronectin only in the absence of extracellular cartilage matrix, and (b) that fibronectin forms only short intercellular "stitches" in the absence of extracellular collagen fibers in vitro.
Mixing translucent polygons with volumes (1999)

We present an algorithm which renders opaque and/or translucent polygons embedded within volumetric data. The processing occurs such that all objects are composited in the correct order, by rendering thin slabs of the translucent polygons between volume slices using slice-order volume rendering. We implemented our algorithm with OpenGL on current general-purpose graphics systems. We discuss our system implementation, speed and image quality, as well as the renderings of several mixed scenes.
Detecting novel business blogs (2009)

Nowadays, blogs have become a popular way for people and organizations to publish news and information to the public, as well as advertise their products. Certain information contained in the blogs represent business opportunities and thus can be utilized by speculators. However, many blogs may often contain similar information and the sheer volume of available information really challenges the ability of organizations to act quickly in today's business environment. Thus, a lot of work has been done to develop a novelty detection system, which is able to single out novel information out of a set of massive text documents. This paper explores the feasibility and performance of detecting novel business blogs, which has not been studied before. The results show that our novelty detection system can detect novelty in our dataset of business blogs with very high accuracy, which indicate that our novelty detection algorithm is successful in detecting novel business blogs.
Hydrogenation of imines catalysed by ruthenium(<scp>ii</scp>) complexes based on lutidine-derived CNC pincer ligands (2012)

The preparation of new Ru(II) complexes incorporating fac-coordinated lutidine-derived CNC ligands is reported. These derivatives are selectively deprotonated by (t)BuOK at one of the methylene arms of the pincer, leading to catalytically active species in the hydrogenation of imines.
Fully automated Web services orchestration in a resource retrieval scenario (2005)

We propose a framework and polynomial algorithms for semantic-based automated Web service orchestration, fully compliant with semantic Web technologies. The approach exploits the recently proposed concept abduction inference service in description logics to solve concept covering problems. We present how the proposed approach deals with not exact solutions, computing an approximate orchestration with respect to an agent request modeled using a significant subset of OWL-DL.
Metabolic Cardiovascular Disease Risk Factors in Women with Self-Reported Symptoms of Oligomenorrhea and/or Hirsutism: Northern Finland Birth Cohort 1966 Study (2004)

The metabolic cardiovascular disease (CVD) risk factors of women with self-reported oligomenorrhea and/or hirsutism, which are symptoms of polycystic ovary syndrome (PCOS), were investigated in a general population-based Northern Finland Birth Cohort 1966 Study to determine whether women with PCOS symptoms at 31 yr would be distinguishable from asymptomatic controls in terms of CVD risk factors. A total of 518 cases with oligomenorrhea and/or hirsutism and 1036 randomly selected controls were analyzed. C-Reactive protein (CRP; median, 0.70 vs. 0.60 mg/liter; P = 0.026), triglycerides (mean, 0.97 vs. 0.91 mmol/liter; P = 0.039), body mass index (BMI; mean, 25.1 vs. 24.2 kg/m(2); P < 0.001), and waist/hip ratio (mean, 0.82 vs. 0.81; P = 0.001) were significantly higher, and high-density lipoprotein cholesterol levels were lower (mean, 1.60 vs. 1.66 mmol/liter; P = 0.002) in the cases compared with the controls. Total cholesterol, low-density lipoprotein cholesterol, and blood pressure showed no statistically significant differences between the cases and the controls. In terms of metabolic CVD risk factors, women reporting hirsutism alone were indistinguishable from the control group, and those who reported both oligomenorrhea and hirsutism had the most severe changes in risk factor profiles. Because obesity is strongly related to PCOS symptoms, the analyses were stratified by BMI. After stratification into normal weight (BMI, <25 kg/m(2)), overweight (25 kg/m(2) <or= BMI <30 kg/m(2)), and obese (BMI, >or=30 kg/m(2)) groups, the waist/hip ratio was significantly higher among the overweight cases (mean, 0.84 vs. 0.83; P = 0.04). Among the obese women, high-density lipoprotein cholesterol was significantly lower (mean, 1.32 vs. 1.48 mmol/liter; P = 0.002) among the cases, and triglycerides tended to be higher (mean, 1.43 vs. 1.27 mmol/liter; P = 0.068) than in controls. In conclusion, these results indicate that self-reported symptoms of oligomenorrhea and/or hirsutism, particularly in the presence of both symptoms, may be helpful to identify women with metabolic cardiovascular risk factor accumulation associated with PCOS.
New polymeric precursors to boron- and zirconium -modified silicon carbide (2001)

Silicon carbide based ceramics have properties such as their high strength and thermal stability that make them desirable as high temperature structural materials. However, traditional methodologies for production of ceramic materials are limiting as they do not allow the formation of complex shapes. The goal of the work described in this dissertation was to develop new single-source polymeric precursors to modified silicon carbide ceramics including SiOCB, SiCB, SiOCZr, and SiOCNZr materials for the production of fibers and matrix materials. Three types of boron-containing polymer precursors to SiCB and SiOCB ceramics were developed. Pinacolborane and diethylborazine-modified polyvinylsiloxanes were synthesized in excellent yields by the RhH(CO)(PPh3) 3 catalyzed reactions of polyvinylsiloxane with either pinacolborane or diethylborazine. The 9-borabicyclo[3.3.1 ]nonane-modified allylhydridopolycarbosilane polymers were also synthesized in high yield by the reaction of allylhydridopolycarbosilane with 9-BBN. The degree of polymer substitution in all cases was controlled by varying the reactant ratios. Bulk pyrolysis of the modified polymers produced SiCB ceramics, with boron contents ranging from 0.2 to 0.7% depending upon the percentage of polymer modification. Density and XRD studies of the 1800°C and 2000°C chars showed that the addition of boron, in fact, affected the degree of crystallization and promoted sintering of the ceramic. Additionally, the pinacolborane-modified polyvinylsiloxane polymers were found to be excellent melt-processable, single-source precursors to small diameter SiOCB fibers, while the 9-BBN-modified allyhydridopolycarbosilane polymers can be used for matrix materials. Three new types of poly(zirconosiloxane), poly(zirconocarbosilane), and poly(zirconosilazane) polymeric precursors were also achieved by the high yield hydrozirconation reactions between polyvinylsiloxane, allylhydridopolycarbosilane, and poly(ureamethylvinyl)silazane and zirconocene chloride hydride. Again the degree of polymer modification was controlled by varying the reactant ratios. All the zirconium-modified polymers had thermal decomposition temperatures similar to their respective parent materials, but that the ceramic yields of the poly(zirconocarbosilane), and poly(zirconosilazane) derived materials were improved over their parents. Bulk pyrolyses of the modified polymers produced SiOCZr, and SiOCNZr ceramic chars with zirconium contents ranging from 0.9 to 2.9%. XRD studies of the ceramics showed that heat resistance and crystal growth were affected by the addition of the zirconium.
ISS Interface Mechanisms and their Heritage (2011)

The International Space Station, by nurturing technological development of a variety of pressurized and unpressurized interface mechanisms fosters competition at the technology level. Such redundancy and diversity allows for the development and testing of mechanisms that might be used for future exploration efforts. The International Space Station, as a test-bed for exploration, has 4 types of pressurized interfaces between elements and 6 unpressurized attachment mechanisms. Lessons learned from the design, test and operations of these mechanisms will help inform the design for a new international standard pressurized docking mechanism for the NASA Docking System. This paper will examine the attachment mechanisms on the ISS and their attributes. It will also look ahead at the new NASA docking system and trace its lineage to heritage mechanisms.
Dosimetric characteristics of a newly designed grid block for megavoltage photon radiation and its therapeutic advantage using a linear quadratic model (2006)

Grid radiation therapy with megavoltage x-ray beam has been proven to be an effective technique for management of large, bulky malignant tumors. The clinical advantage of GRID therapy, combined with conventional radiation therapy, has been demonstrated using a prototype GRID block [Mohiuddin, Curtis, Grizos, and Komarnicky, Cancer 66, 114-118 (1990)]. Recently, a new GRID block design with improved dosimetric properties has become commercially available from Radiation Product Design, Inc. (Albertive, MN). This GRID collimator consists of an array of focused apertures in a cerrobend block arranged in a hexagonal pattern having a circular cross-section with a diameter and center-to-center spacing of 14.3 and 21.1 mm, respectively, in the plane of isocenter. In this project, dosimetric characteristics of the newly redesigned GRID block have been investigated for a Varian 21EX linear accelerator (Varian Associates, Palo Alto, CA). These determinations were performed using radiographic films, thermoluminescent dosimeters in Solid Water phantom materials, and an ionization chamber in water. The output factor, percentage depth dose, beam profiles, and isodose distributions of the GRID radiation as a function of field size and beam energy have been measured using both 6 and 18 MV x-ray beams. In addition, the therapeutic advantage obtained from this treatment modality with the new GRID block design for a high, single fraction of dose has been calculated using the linear quadratic model with alpha/beta ratios for typical tumor and normal cells. These biological characteristics of the new GRID block design will also be presented.
Blue avalanche upconversion in Tm:ZBLAN fiber (1997)

We report the investigation of the photon avalanche effect in heavily doped Tm:ZBLAN fiber at room temperature. Pumping at 630–650 nm, which is not resonant with the ground-state absorption, gives intense blue emissions at 450 and 480 nm. The time evolution of the absorption and emission shows a slowly decaying oscillation before steady state is reached.
Measurements of Aerosol Particle Sizes from a Direct Injection Nebulizer (1991)

Photographs and laser-scattering measurements showed that a direct injection nebulizer (DIN) produced a finer aerosol with a narrower drop size distribution than that for a conventional glass concentric nebulizer when both were operated at the same liquid and nebulizer gas flow rates. The droplets from the DIN were slightly larger, however, than those leaving a Scott-type spray chamber with a glass concentric nebulizer. The droplets from the DIN had a Sauter mean diameter of ∼7 μm and a 90% mass diameter of 11–16 μm. The droplet size distribution became narrower and shifted to lower diameters as the aerosol gas flow rate increased.
IL-6 and Serum Amyloid A Synergy Mediates Angiotensin II–Induced Muscle Wasting (2009)

Animal studies suggest that increased levels of circulating angiotensin II (AngII) could contribute to the loss of lean body mass in chronic kidney disease, but the mechanism by which this occurs is unclear. Here, AngII infusion increased circulating IL-6 and its hepatic production in wild-type mice, suggesting that AngII-induced inflammation may trigger muscle loss. AngII infusion also stimulated the suppressor of cytokine signaling (SOCS3) in muscle, which led to loss of insulin receptor substrate 1 (IRS-1), thereby impairing insulin/IGF-1 signaling and enhancing protein degradation. All of these responses to AngII were suppressed in IL-6-deficient mice. Recombinant human IL-6 (rhIL-6) treatment of cultured myotubes only minimally increased SOCS3, however, suggesting the contribution of other mediators. Because AngII increases hepatic serum amyloid A (SAA) expression in an IL-6-dependent manner, we treated wild-type mice with rhIL-6 and an SAA1-overexpressing adenovirus; the combination led to a significantly greater increase in SOCS3 and decrease in IRS-1 compared with either rhIL-6 or SAA1 alone. We observed similar effects on SOCS3 and IRS-1 when we treated cultured muscle myotubes with rhIL-6 and SAA1. Taken together, these results suggest an interorgan response to high levels of AngII: Hepatic production of IL-6 and SAA increases, and these mediators act synergistically to impair insulin/IGF-1 signaling, which promotes muscle proteolysis. Targeting the high levels of IL-6 and SAA in catabolic disorders might be a therapeutic approach to prevent muscle wasting.
Blood platelet-derived microparticles release and bubble formation after an open-sea air dive (2012)

Bubble-induced platelet aggregation offers an index for evaluating decompression severity in humans and in a rat model of decompression sickness. Endothelial cells, blood platelets, or leukocytes shed microparticles (MP) upon activation and during cell apoptosis. The aim was to study blood platelet MP (PMP) release and bubble formation after a scuba-air dive in field conditions. Healthy, experienced divers were assigned to 1 experimental group (n = 10) with an open-sea air dive to 30 msw for 30 min and 1 control group (n = 5) during head-out water immersion for the same period. Bubble grades were monitored with a pulsed doppler according to Kissman Integrated Severity Score (KISS). Blood samples for platelet count (PC) and PMP (annexin V and CD41) were taken 1 h before and after exposure in both groups. The result showed a decrease in post-dive PC compared with pre-dive values in experimental group with no significant change in the control group. We observed a significant increase in PMP values after the dive while no change was revealed in the control group. There was a significant positive correlation between the PMP values after the dive and the KISS bubble score. The present study highlighted a relationship between the post-dive decrease in PC, platelet MP release, and bubble formation. Release of platelet MPs could reflect bubble-induced platelet aggregation and could play a key role in alteration of the coagulation. Further studies must investigate endothelial and leukocyte MP release in the same field conditions.
Reactions of Haloboranes with Organocyclosiloxanes. I. Boron Chloride with Methyl and Ethyl Trimer and Tetramer<sup>1,2</sup> (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Haloboranes with Organocyclosiloxanes. I. Boron Chloride with Methyl and Ethyl Trimer and Tetramer1,2Patrick A. McCusker and Thomas OstdickCite this: J. Am. Chem. Soc. 1958, 80, 5, 1103–1106Publication Date (Print):March 1, 1958Publication History Published online1 May 2002Published inissue 1 March 1958https://pubs.acs.org/doi/10.1021/ja01538a022https://doi.org/10.1021/ja01538a022research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
AVO Inversion of Troll Field Data (1995)

A stratigraphic elastic inversion scheme (Helgesen and Landrø, 1993) has been applied to a data set from the Troll East field. Both traveltime information and reflection amplitudes have been used to extract P- and S-wave velocities and densities from the seismic data. Since the P-wave velocity has an effect upon both the traveltime and the reflection strength, this is the best resolved parameter. S-wave velocities are mainly determined from variation of reflection amplitude with angle of incidence. The inversion was carried out in the t - p domain.
Logic programming applied to hardware design specification and verification (1984)

This paper proposes the use of logic programming techniques in the specification and verification of hardware designs. Logic programming specifications are formal and directly executable. The advantages of executable specifications are: (1) the specification is itself a prototype of the specified system, (2) incremental development of specifications is possible, (3) behavior exhibited by the specification when executed can be used to check conformity of the specification with requirements. We discuss how Horn clause logic, which has a procedural interpretation, and predicate logic programming language, Prolog, can be used as a hardware description language to specify and verify the correctness of hardware systems. The Prolog system possesses a backtracking mechanism and a powerful pattern-matching feature which is based on unification. A novel feature of the proposed approach is that it can be used to answer interesting questions about a hardware design without resorting to simulation.
Shear mode griding (2003)

It is argued that (1) shear-mode grinding of glass occurs with abrasive particle sizes less than 1 mu m, that it is the mechanical limit of the more common mechanical-chemical glass polishing, and that the debris is insufficient in size to perform the function of eroding the binder in the grinding wheel and thus necessitates the addition of an abrasive and/or chemical additions to the coolant to effect wheel-dressing. The work groups together a series of observations and work by authors and others which, when taken together, forms a picture of shear and mode grinding in a production environment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Carbonic anhydrase activity in first-order sensory neurons of the rat. (1983)

Free accessAbstractFirst published February 1983Carbonic anhydrase activity in first-order sensory neurons of the rat.V Wong, C P Barrett, […], E J Donati, L F Eng, and L Guth, +2 -2Volume 31, Issue 2https://doi.org/10.1177/31.2.6403607
Changing the hydrogen-bonding potential in the DNA binding site of EcoRI by site-directed mutagenesis drastically reduces the enzymic activity, not, however, the preference of this restriction endonuclease for cleavage within the site -GAATTC- (1989)

According to the X-ray structure analysis of an EcoRI-oligodeoxynucleotide complex [McClarin et al. (1986) Science 234, 1526], sequence specificity is mediated by 12 hydrogen bonds, 6 from each of the two identical subunits of the dimeric enzyme to the recognition site -GAATTC-: Arg200 forms two hydrogen bonds with guanine, while Glu144 and Arg145 form four hydrogen bonds to adjacent adenine residues. Changing the hydrogen-bonding potential at the recognition site without perturbing the rest of the interface should lead to the recognition of degenerate sequences [Rosenberg et al. (1987) in Protein Engineering (Oxender, D. L., & Fox, C. F., Eds.) pp 237-250, Liss, New York]. We have shown previously that replacing Glu144 by Gln and Arg145 by Lys affects the activity of the enzyme, not, however, its specificity [Wolfes et al. (1986) Nucleic Acids Res. 14, 9063]. We show now that also the mutation of Arg200 to Lys, the double mutation Glu144Arg145 to GlnLys, and the triple mutation Glu144Arg145Arg200 to GlnLysLys do not lead to a detectable degeneracy of the specificity of cleavage by EcoRI but significantly impair the catalytic activity of this enzyme. A detailed analysis of the steady-state kinetics of cleavage of pUC8 DNA and a tridecadeoxynucleotide substrate demonstrates that the reduction in activity for all DNA binding site mutants investigated so far is mainly due to a decrease in kcat, with the exception of the Arg200 to Lys mutant, which is only impaired in its KM.(ABSTRACT TRUNCATED AT 250 WORDS)