gebhart/patrepeval huggingface dataset:
Effects of Varying Light Intensities and Temperature Treatments Applied to Whole Plants, or Locally to Leaves or Flower Buds, on Growth and Pigmentation of ‘Baccara’ Roses (1974)

Abstract Varying light intensity and temperature treatments were applied to whole plants, or to the leaves, or to the flower buds of ‘Baccara’ roses. The effect of these treatments on flower dimensions and pigmentation of the petals was examined. Cooling only the leaves had no effect; cooling only the buds enhanced both bud weight and pigmentation, but the effect was less marked than when the whole plant was cooled. Reducing plant temperature by misting with desalinated water enhanced both pigmentation and flower size. Darkening of only the leaves, or their removal, resulted in an inhibition of the pigmentation and also in a decrease in bud weight. Darkening of only the flower bud did not affect either pigmentation or bud weight, but caused bud elongation. It is suggested that light intensity and temperature affect flower growth and pigmentation via their effects on the availability of sugars in the flower bud.
Photo and thermal polymerization of epoxides and vinyl ethers by novel sulfonium salts (2008)

Abstract Novel Sulfonium salts with non‐nucleophilic anions were synthesized and applicability of these salts as initiators was demonstrated by carried out polymerization (photo and thermal) of epoxides as well as vinyl ether monomers. Newly synthesized initiators showed good activity for the photo and thermal polymerization. Synthesis, characterization, and activity of initiators have been described. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008.
Combining and comparing EEG, peripheral physiology and eye-related measures for the assessment of mental workload (2014)

While studies exist that compare different physiological variables with respect to their association with mental workload, it is still largely unclear which variables supply the best information about momentary workload of an individual and what is the benefit of combining them. We investigated workload using the n-back task, controlling for body movements and visual input. We recorded EEG, skin conductance, respiration, ECG, pupil size and eye blinks of 14 subjects. Various variables were extracted from these recordings and used as features in individually tuned classification models. Online classification was simulated by using the first part of the data as training set and the last part of the data for testing the models. The results indicate that EEG performs best, followed by eye related measures and peripheral physiology. Combining variables from different sensors did not significantly improve workload assessment over the best performing sensor alone. Best classification accuracy, a little over 90%, was reached for distinguishing between high and low workload on the basis of 2 min segments of EEG and eye related variables. A similar and not significantly different performance of 86% was reached using only EEG from single electrode location Pz.
Approaches to extra low voltage DRAM operation by SOI-DRAM (1998)

The newly designed scheme for a low-voltage 16 MDRAM/SOI has been successfully realized and the functional DRAM operation has been obtained at very low supply voltage below 1 V. The key process and circuit technologies for low-voltage/high-speed SOI-DRAM will be described here. The extra low voltage DRAM technologies are composed of the modified MESA isolation without parasitic MOS operation, the dual gate SOI-MOSFETs with tied or floating bodies optimized for DRAM specific circuits, the conventional stacked capacitor with increased capacitance by thinner dielectric film, and the other bulk-Si compatible DRAM structure. Moreover, a body bias control technique was applied for body-tied MOSFETs to realize high performance even at low voltage. Integrating the above technologies in the newly designed 0.5-/spl mu/m 16 MDRAM, high-speed DRAM operation of less than 50 ns has been obtained at low supply voltage of 1 V.
British Autobiography in the Seventeenth Century; John Donne: Conservative Revolutionary; George Herbert's Lyrics (1970)

British Autobiography in the Seventeenth Century; John Donne: Conservative Revolutionary; George Herbert's Lyrics Get access British Autobiography in the Seventeenth Century. By Paul Delany. Routledge. 40s.John Donne: Conservative Revolutionary. By N. J. C. Andreasen. Oxford ( Princeton U.P.). 66s. 6d.George Herbert's Lyrics. By Arnold Stein. Oxford ( Johns Hopkins P.). 76s. Gilbert Thomas Gilbert Thomas Search for other works by this author on: Oxford Academic Google Scholar English: Journal of the English Association, Volume 19, Issue 103, Spring 1970, Pages 26–27, https://doi.org/10.1093/english/19.103.26 Published: 01 March 1970
A divide‐and‐conquer approach to determine the Pareto frontier for optimization of protein engineering experiments (2011)

In developing improved protein variants by site-directed mutagenesis or recombination, there are often competing objectives that must be considered in designing an experiment (selecting mutations or breakpoints): stability versus novelty, affinity versus specificity, activity versus immunogenicity, and so forth. Pareto optimal experimental designs make the best trade-offs between competing objectives. Such designs are not "dominated"; that is, no other design is better than a Pareto optimal design for one objective without being worse for another objective. Our goal is to produce all the Pareto optimal designs (the Pareto frontier), to characterize the trade-offs and suggest designs most worth considering, but to avoid explicitly considering the large number of dominated designs. To do so, we develop a divide-and-conquer algorithm, Protein Engineering Pareto FRontier (PEPFR), that hierarchically subdivides the objective space, using appropriate dynamic programming or integer programming methods to optimize designs in different regions. This divide-and-conquer approach is efficient in that the number of divisions (and thus calls to the optimizer) is directly proportional to the number of Pareto optimal designs. We demonstrate PEPFR with three protein engineering case studies: site-directed recombination for stability and diversity via dynamic programming, site-directed mutagenesis of interacting proteins for affinity and specificity via integer programming, and site-directed mutagenesis of a therapeutic protein for activity and immunogenicity via integer programming. We show that PEPFR is able to effectively produce all the Pareto optimal designs, discovering many more designs than previous methods. The characterization of the Pareto frontier provides additional insights into the local stability of design choices as well as global trends leading to trade-offs between competing criteria.
Measuring Quality of Life in Asthma (1993)

The aim of this study was to evaluate the measurement properties of an Asthma Quality of Life Questionnaire. The study design was an 8-wk unblinded single cohort with assessments at 0, 4, and 8 wk. Thirty-nine adults with symptomatic asthma and a wide range of airway responsiveness and medication requirements were enrolled from previous studies and through notices in the local media. Those with inadequately controlled asthma were offered an inhaled steroid (budesonide). Asthma Quality of Life Questionnaire, spirometry, a clinical asthma control questionnaire, medication requirements, airway responsiveness to methacholine, the Sickness Impact Profile, and the Rand questionnaire were recorded at each visit. Patients kept daily diaries of peak flow rates and medications. The Asthma Quality of Life Questionnaire was able to detect changes in patients who responded to treatment or who had natural fluctuations in their asthma (p < 0.001) and to differentiate these patients from those who remained stable (p < 0.001). The Questionnaire was reproducible in patients who were stable (intraclass correlation coefficient = 0.92). There were significant longitudinal and cross-sectional correlations between asthma quality of life and other measures of both clinical asthma and generic quality of life. We conclude that the Asthma Quality of Life Questionnaire has good measurement properties and that it is valid as both an evaluative and a discriminative instrument. It measures the component of asthma most important to patients, and it should be considered for inclusion in all asthma studies.
Consecutive determination of alkali metal bromides and thiocyanates in mixtures (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConsecutive determination of alkali metal bromides and thiocyanates in mixturesJames E. Burroughs and Alan I. AttiaCite this: Anal. Chem. 1968, 40, 13, 2052–2053Publication Date (Print):November 1, 1968Publication History Published online1 May 2002Published inissue 1 November 1968https://pubs.acs.org/doi/10.1021/ac60269a039https://doi.org/10.1021/ac60269a039research-articleACS PublicationsRequest reuse permissionsArticle Views25Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Knowledge discovery and constraint-based processing in automated manufacturing (2002)

This paper studies the application of integrated database and artificial intelligence technologies in automated manufacturing. Two interesting techniques: (1) knowledge discovery, i.e., discovery of interesting rules and regularities from data or processing history, and (2) constraint-based processing, i.e., the application of the knowledge and rules as constraints in the guidance or control of a manufacturing process, are examined in detail. The study shows that the proposed technique may extract interesting knowledge from data, guide manufacturing processes and enhance system performance. Therefore, it may have important implications to computer-integrated manufacturing systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Encoding Method for OBOC Small Molecule Libraries Using a Biphasic Approach for Ladder-Synthesis of Coding Tags (2004)

In the "one-bead one-compound" (OBOC) combinatorial library method, each compound bead displays only one compound entity. Hundreds of thousands to millions of compound beads can be synthesized rapidly and screened simultaneously. Positive compound beads are then isolated for structural analysis. To fully exploit the power of OBOC combinatorial small molecule libraries, a robust and high throughput encoding method is needed to decode the positive compound beads. In this paper, we report on the development of a novel encoding strategy that combines the concepts of ladder-synthesis and chemical encoding on bilayer beads. In these encoded libraries, small molecule compounds are displayed on the bead surface, and cleavable coding tags consisting of a series of truncated molecules reside in the bead interior. Such a library can be easily constructed using the biphasic approach (J. Am. Chem. Soc.2002, 124, 7678) to topologically segregate the functionalities of the beads during library synthesis. The ladder members and coding tags are then released for MALDI-TOF-MS analysis. To simplify the interpretation of the mass spectra, we purposely add bromine into the cleavable linker so that the cleavage products generate a characteristic isotope fingerprint. The chemical structure of library compounds can be determined by analyzing the mass differences between adjacent peaks on the mass spectra. This encoding strategy also provides valuable information on the quality of the testing compound on the surface of the bead. To validate this methodology, a model OBOC small molecule library with 12,288 members was synthesized on TentaGel beads and screened against streptavidin. The chemical structures of the compound on each positive bead were unambiguously identified.
A Frequency-Tunable Comb Resonator Using Spring Tension and Compression Effects (2004)

A 2μm-thick frequency-tunable microresoantor capable of either increasing or decreasing its resonant frequency by a combination of Joule heating and electrostatic force has been successfully demonstrated for the first time. For the heating voltage increase from 0 to 2V under fixed bias voltage of 40V, the resonant frequency changes from 22.2kHz to 16.2kHz, resulting in the 27% reduction in the resonant frequency. For the bias voltage change from 20V to 40V under the heating voltage of 0V, the resonant frequency increase from 19.0kHz to 23.6kHz, resulting in the 24.2% increase in the resonant frequency. As such, this surface-micromachined microactuator could assist complicated frequency tuning for applications of microsensors and microactuators.
The GILUPI CellCollector as an in vivo tool for circulating tumor cell enumeration and molecular characterization in lung cancer patients. (2015)

e22035 Background: Tumor tissue based analysis is not always possible and represents only a single-snapshot in time. Liquid biopsy can supply further information on prognosis, treatment efficacy and molecular tumor evolution by isolating and analyzing circulating tumor cells (CTCs). Usually, CTCs are isolated in vitro from limited volumes of patient blood samples. To overcome this limitation, the GILUPI CellCollector was used in lung cancer patients to isolate CTCs in vivoin comprehensive studies. We showed the high efficient isolation results combined with mutations detection (EGFR and KRAS) in CTCs of patients with known primary tumor mutation. In addition new molecular assays for CTCs isolated with the GILUPI CellCollector were established (characterization of ALK, PD-L1) - making it an ideal tool for liquid biopsy and clinical diagnostics. Methods: In total, 62 lung cancer patients (NSCLC and SCLC) were screened for CTCs in a single device application. In parallel, blood samples were analyzed with the CellSearch system. CTC enumeration was conducted by immunofluorescence microscopy using both technologies. In a second set of patients CTC enumeration and molecular characterization using the GILUPI CellCollector is conducted. The downstream diagnostic of isolated CTCs is performed by immunofluorescence microscopy with specific antibodies (ALK, PD-L1) and different molecular diagnostic assays (EGFR, KRAS) like digital PCR, qRT-PCR and sequencing. Results: The successful isolation of CTCs was significantly more frequent with the GILUPI CellCollector (73%) compared to CellSearch (29%). In the second set of patients EGFR and KRAS mutations could be detected after previous immunofluorescence microscopy. Preliminary data of the ALK and PD-L1 investigation showed the possible detection of ALK and PD-L1. Conclusions: The GILUPI CellCollector overcomes blood volume limitations of other diagnostic approaches and increases the diagnostic sensitivity of CTC isolation. It allows CTC enumeration and molecular characterization which could help guiding treatment strategies, monitoring therapy efficacy and resistance development.
Sensitivity of Viruses to Phosphorylated 9-(2-hydroxyethoxymethyl)Guanine Revealed in TK-transformed Cells (1980)

Vaccinia and pseudorabies viruses are resistant to ACV [Acyclovir or 9-(2-hydroxyethoxymethyl)guanine] in normal cells. However, both viruses are sensitive in thymidine kinase (TK)-transformed cells in which the resident HSV-specific TK is able to phosphorylate the drug. This demonstrates the sensitivity of these viruses to phosphorylated ACV and suggests a wider antiviral activity for the phosphorylated drug.
Scripting language for state configured layered control of the Tethys long range autonomous underwater vehicle (2010)

A scripting language for state configured layered control of a long range autonomous underwater vehicle (AUV) is introduced. The XML-based language has been designed to meet the complex requirements for long-term autonomous operation. It does not require that mission planners be programmers, yet allows them to have a high degree of certainty at deployment that the robot will do what they want it to do. The script is simple to execute on the vehicle, both to minimize CPU power usage and to minimize the chance of failure due to complexity. Users do not need a high-fidelity model of the AUV to plan a mission, as the robot may change in unexpected ways over the course of the mission. Those who wish to do more advanced programming of mission commands and behaviors can do so in the script and are not able to crash the vehicle's operating system. To address these needs, the “Tethys script” state-configured layered control language has been developed.
Swapping between Fas and Granulocyte Colony-stimulating Factor Receptor (1996)

Fas belongs to the tumor necrosis factor/nerve growth factor receptor family. The Fas ligand binds to its receptor, Fas, and induces apoptosis in Fas-bearing cells. The granulocyte colony-stimulating factor receptor (G-CSFR) is a member of the hemopoietic growth factor receptor family. G-CSF induces its dimerization and regulates the proliferation and differentiation of neutrophilic granulocytes. We constructed hybrid receptors between Fas and G-CSFR and expressed them in the mouse T cell line WR19L or the mouse myeloid interleukin-3-dependent FDC-P1 cell line. The Fas ligand or an agonistic anti-Fas antibody stimulated proliferation of the FDC-P1 transformants expressing a chimera consisting of the Fas extracellular and G-CSFR cytoplasmic regions. On the other hand, G-CSF could not induce apoptosis in the transformants expressing the chimera consisting of the G-CSFR extracellular and Fas cytoplasmic regions, but these cells were killed by a polyclonal antibody against G-CSFR. These results indicated that receptors belonging to different receptor families can be functionally exchanged and confirm that a homodimer of G-CSFR can transduce the growth signal, whereas Fas must be oligomerized (probably trimerized) to transduce the apoptotic signal.
Signal Processing by Electron-Beam Interaction with Piezoelectric Surface Waves (1973)

A new type of device is described in which an acoustoelectric surface wave interacts with low energy free charges created on the surface of a piezoelectric material. The experimental results obtained show that one of the most promising applications is an analog RF storage device for which several minutes of storage time have been achieved at 30 MHz on quartz with an internal insertion loss of 63 dB. If the width of the current pulse is large enough, direct attenuation of the surface wave may be measured due to the energy absorbed by the motion of secondary electrons. Experimental and theoretical results are presented. The limitations and the applications of the device to signal processing are discussed.
Conatumumab: a novel monoclonal antibody against death receptor 5 for the treatment of advanced malignancies in adults (2011)

Conatumumab, at a dose of 20 mg/kg every 2 weeks, has demonstrated acceptable safety and tolerability in patients with advanced tumors based on available and published data. Further clinical trials are underway evaluating the use of conatumumab in combination with chemotherapeutic and targeted agents.
E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1) (2005)

Protein ubiquitinylation plays a key role in many important cellular processes. Ubiquitinylation requires the E1 ubiquitin-activating enzyme, an E2 ubiquitin-conjugating enzyme, and, frequently, a substrate-specific E3 ubiquitin-protein ligase. In one class of E3 ubiquitin ligases, the catalytic domain contains a zinc-binding RING finger motif. ARD1 (ADP-ribosylation factor domain protein 1), with a RING finger domain in the N-terminal region, two predicted B-Boxes, and a coiled-coil protein interaction motif immediately preceding an ADP-ribosylation factor domain at the C terminus, belongs to the TRIM (Tripartite motif) or RBCC (RING, B-Box, coiled-coil) family. The region containing the B-Boxes and the coiled-coil motif acts as a GTPase-activating protein for the ADP-ribosylation factor domain of ARD1. We report here that full-length ARD1 or the RING finger domain (residues 1-110) produced polyubiquitinylated proteins in vitro in the presence of mammalian E1, an E2 enzyme (UbcH6 or UbcH5a, -5b, or -5c), ATP, and ubiquitin. Deletion of the RING region or point mutations within the RING sequence abolished ARD1 E3 ligase activity. All data are consistent with a potential function for ARD1 as an E3 ubiquitin ligase in cells.
Superconducting Extremely Low Frequency (ELF) Magnetic Field Sensors for Submarine Communications (1974)

The ferromagnetic-core type of solenoid that is used as a trailed antenna for communications reception by submarines has not demonstrated adquate sensitivity to satisfy the performance requirements for deeply submerged submarines receiving extremely low frequency (ELF) transmissions from the planned Sanguine communications system. It is possible, however, that a superconducting quantum interference device (SQUID) can be adapted to this role successfully and can permit all requirements of platform depth, speed, and maneuverability to be met. The present status of SQUID's is described, and some laboratory measurements that prove the potential of these devices for the ELF communications reception capability are presented. The engineering development that must be pursued in the areas of 1) sensor and electronics dynamic range, 2) sensor orthogonality, and 3) refrigeration systems to make SQUID ELF sensors available as operational receiving antennas is also discussed.
Pretreatment With Electroacupuncture Induces Rapid Tolerance to Focal Cerebral Ischemia Through Regulation of Endocannabinoid System (2009)

We conclude that pretreatment with EA increases the production of endocannabinoid 2-arachidonylglycerol and N-arach-idonoylethanolamine-anandamide, which elicits protective effects against transient cerebral ischemia through CB1 receptors. These results suggest a novel mechanism of EA pretreatment-induced rapid tolerance to focal cerebral ischemia.
Laser-induced disassembly of a graphene single crystal into a nanocrystalline network (2009)

We report about investigations of time-dependent structural modifications in single-crystal graphene due to laser irradiation even at moderate power levels of 1 mW in a diffraction-limited spot. The modifications have been characterized by in situ scanning confocal Raman spectroscopy, atomic force height microscopy, and transport studies. The time evolution of the Raman spectrum reveals two different effects: on a short-time scale, dopants, initially present on the flake, are removed. The longer time scale behavior points to a laser induced gradual local decomposition of single-crystal graphene into a network of interconnected nanocrystallites with a characteristic length scale of approximately 10 nm due to bond breaking. The broken bonds offer additional docking sites for adsorbates as confirmed in transport and AFM height studies. These controlled structural modifications may for instance be valuable for enhancing the local reactivity, trimming graphene based gas sensors and generating spatially varying doping patterns.