gebhart/patrepeval huggingface dataset:
The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen. (1995)

Serum IgE concentrations and the expression of the low-affinity receptor for IgE (Fc epsilon RII/CD23) are increased in cutaneous leishmaniasis or after immune challenge with Leishmania antigens. In vitro, the ligation of CD23 by IgE-anti-IgE immune complexes (IgE-IC) or by anti-CD23 monoclonal antibody (mAb) induces nitric oxide (NO) synthase and the generation of various cytokines by human monocytes/macrophages. The present study shows that IgE-IC, via CD23 binding, induce intracellular killing of Leishmania major in human monocyte-derived macrophages through the induction of the L-arginine:NO pathway. This was demonstrated by increased generation of nitrite (NO2-), the stable oxidation product of NO, and by the ability of NG-monomethyl-L-arginine to block both NO generation and parasite killing. A similar NO-dependent effect was observed with interferon gamma-treated cells. Tumor necrosis factor alpha is involved in this process, since both the induction of NO synthase and the killing of parasites caused by anti-CD23 mAb were inhibited by an anti-tumor necrosis factor alpha mAb. Treatment of noninfected CD23+ macrophages with IgE-IC provided protection against subsequent in vitro infection of these cells by Leishmania major promastigotes. Thus, IgE-IC promote killing of L. major by inducing NO synthase in human macrophages.
The effect of ambient light on QLF analyses (2002)

The use of optical methods in the diagnosis of early caries is developing rapidly. The introduction of the quantitative light-induced fluorescence (QLF) device has promised the use of a quantifiable technique in vivo. This study describes the effect that ambient light has upon the reliability of QLF analyses. Using human teeth and simulated lesions the study examined the effect of 15 different light levels on three severities of carious lesions. The study found that a light level of 88 lux could be employed in areas where QLF is to be used without significantly affecting the reported value, DeltaQ. This study impacts upon the health and safety issues surrounding QLF usage as well as ethical issues relating to working in dark environments.
Object-oriented development of software systems for power system simulations (2002)

The software systems developed for power system simulations have evolved into such complicated systems that the applied design practices appear inadequate to support further enhancement and maintenance. The major obstacles stem directly or indirectly from the conventional function-oriented software development methodologies. To overcome the drawbacks of these methodologies, this paper proposes applying object-oriented technology for power system software development. As an illustration of this approach, the object modeling technique (OMT), an object-oriented software development methodology, is used to develop a distribution analysis system. With this technique, a generic distribution circuit object model (DCOM) is designed based on the real-world concepts and implemented with the object-oriented programming techniques. The developed DCOM is capable of supporting a wide range of distribution applications and allowing modification and maintenance over a long period of time. The performed case study has demonstrated that object-oriented technology, when applied to each stage of software development, can help achieve complicated tasks in power system simulations.
The Effects of Aging and Training on Skeletal Muscle (1998)

Aging results in a gradual loss of muscle function, and there are predictable age-related alterations in skeletal muscle function. The typical adult will lose muscle mass with age; the loss varies according to sex and the level of muscle activity. At the cellular level, muscles loose both cross-sectional area and fiber numbers, with type II muscle fibers being the most affected by aging. Some denervation of fibers may occur. The combination of these factors leads to an increased percentage of type 1 fibers in older adults. Metabolically, the glycolytic enzymes seem to be little affected by aging, but the aerobic enzymes appear to decline with age. Aged skeletal muscle produces less force and there is a general "slowing" of the mechanical characteristics of muscle. However, neither reduced muscle demand nor the subsequent loss of function is inevitable with aging. These losses can be minimized or even reversed with training. Endurance training can improve the aerobic capacity of muscle, and resistance training can improve central nervous system recruitment of muscle and increase muscle mass. Therefore, physical activity throughout life is encouraged to prevent much of the age-related impact on skeletal muscle.
Automated object persistence for JavaScript (2010)

Traditionally web applications have required an internet connection in order to work with data. Browsers have lacked any mechanisms to allow web applications to operate offline with a set of data to provide constant access to applications. Recently, through browser plug-ins such as Google Gears, browsers have gained the ability to persist data for offline use. However, until now it's been difficult for a web developer using these plug-ins to manage persisting data both locally for offline use and in the internet cloud due to: synchronization requirements, managing throughput and latency to the cloud, and making it work within the confines of a standards-compliant web browser. Historically in non-browser environments, programming language environments have offered automated object persistence to shield the developer from these complexities. In our research we have created a framework which introduces automated persistence of data objects for JavaScript utilizing the internet. Unlike traditional object persistence solutions, ours relies only on existing or forthcoming internet standards and does not rely upon specific runtime mechanisms such as OS or interpreter/compiler support. A new design was required in order to be suitable to the internet's unique characteristics of varying connection quality and a browser's specific restrictions. We validate our approach using benchmarks which show that our framework can handle thousands of data objects automatically, reducing the amount of work needed by developers to support offline Web applications.
Concept of a miniature atomic sensor (2014)

We present preliminary results of our research program towards multi-axis quantum acceleration sensors in a compact package, using Bloch oscillations of matter waves to provide large momentum transfer. The projected performance is discussed. We demonstrate the first Mach-Zehnder atom interferometer in which a cavity mode is used for addressing the atoms.
ELECTRONIC PASSENGER INFORMATION SYSTEMS : DO THEY GIVE THE PUBLIC WHAT THEY WANT? (1991)

Examines the potential of electronic passenger information systems to fill in some of the gaps in the provision of Public transport passenger information. Also describes user reaction to experimental information terminals introduced in the United Kingdom.
Radio Control of Model Flying Boats (1947)

A new method of carrying on flying-boat hull design involves radio control of free-flight models. The scale factors of the models are such that severe weight and space limitations are imposed on the radio-control equipment, considering the complexity of control. Seven independent channels capable of simultaneous operation are needed. Five accomplish proportional positioning and two perform switching operations. A single radio-frequency carrier is used, amplitude-modulated by seven control tones. The factors affecting the positioning accuracy are discussed. A compensating circuit is described which corrects for variations in receiver output with charges of battery voltage and distance from the control station. Over-all positioning accuracy is plus or minus 4 per cent. Operating experience includes nearly 1000 test runs utilizing scale models of three different types of flying boats.
Most rhesus macaques infected with the CCR5-tropic SHIV <sub>AD8</sub> generate cross-reactive antibodies that neutralize multiple HIV-1 strains (2012)

The induction of broadly reacting neutralizing antibodies has been a major goal of HIV vaccine research. Characterization of a pathogenic CCR5 (R5)-tropic SIV/HIV chimeric virus (SHIV) molecular clone (SHIV(AD8-EO)) revealed that eight of eight infected animals developed cross-reactive neutralizing antibodies (NAbs) directed against an envelope glycoprotein derived from the heterologous HIV-1(DH12) strain. A panel of plasmas, collected from monkeys inoculated with either molecularly cloned or uncloned SHIV(AD8) stocks, exhibited cross-neutralization against multiple tier 1 and tier 2 HIV-1 clade B isolates. One SHIV(AD8)-infected animal also developed NAbs against clades A and C HIV-1 strains. In this particular infected macaque, the cross-reacting anti-HIV-1 NAbs produced between weeks 7 and 13 were directed against a neutralization-sensitive virus strain, whereas neutralizing activities emerging at weeks 41-51 targeted more neutralization-resistant HIV-1 isolates. These results indicate that the SHIV(AD8) macaque model represents a potentially valuable experimental system for investigating B-cell maturation and the induction of cross-reactive NAbs directed against multiple HIV-1 strains.
CMOS digital imager design from a system-on-a-chip perspective (2003)

Due to substantial mixed analog-digital circuit integration in one chip, CMOS digital imager cannot be considered only as a photoelectric transducer. In this paper, we have identified timing and circuit layout considerations that are critical for implementing a digital CMOS camera-on-a-chip. An optimized binary-scaled tree-topology power routing has been shown to be critical for minimizing chip area and providing low spatial pattern noise. Imaging artifacts due to timing asymmetry have been quantified, and methods for elimination of the artifacts have been demonstrated. The impact of on-chip bias-generation and drive circuits on the on-chip ADC performance has been shown. New timing and circuit layout techniques have been presented for enabling random noise limited performance of a CMOS imager.
Three Classes of Ubiquinone Analogs Regulate the Mitochondrial Permeability Transition Pore through a Common Site (2000)

To identify the structural features required for regulation of the mitochondrial permeability transition pore (PTP) by ubiquinone analogs (Fontaine, E., Ichas, F., and Bernardi, P. (1998) J. Biol. Chem. 40, 25734-25740), we have carried out an analysis with quinone structural variants. We show that three functional classes can be defined: (i) PTP inhibitors (ubiquinone 0, decylubiquinone, ubiquinone 10, 2,3-dimethyl-6-decyl-1,4-benzoquinone, and 2,3,5-trimethyl-6-geranyl-1,4-benzoquinone); (ii) PTP inducers (2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone and 2,5-dihydroxy-6-undecyl-1,4-benzoquinone); and (iii) PTP-inactive quinones that counteract the effects of both inhibitors and inducers (ubiquinone 5 and 2,3,5-trimethyl-6-(3-hydroxyisoamyl)-1,4-benzoquinone) . The structure-function correlation indicates that minor modifications in the isoprenoid side chain can turn an inhibitor into an activator, and that the methoxy groups are not essential for the effects of quinones on the PTP. Since the ubiquinone analogs used in this study have a similar midpoint potential and decrease mitochondrial production of reactive oxygen species to the same extent, these results support the hypothesis that quinones modulate the PTP through a common binding site rather than through oxidation-reduction reactions. Occupancy of this site can modulate the PTP open-closed transitions, possibly through secondary changes of the PTP Ca(2+) binding affinity.
Land use and habitat conditions across the southwestern Wyoming sagebrush steppe: development impacts, management effectiveness and the distribution of invasive plants (2011)

For the past several years, USGS has taken a multi-faceted approach to investigating the condition and trends in sagebrush steppe ecosystems. This recent effort builds upon decades of work in semi-arid ecosystems providing a specific, applied focus on the cumulative impacts of expanding human activities across these landscapes. Here, we discuss several on-going projects contributing to these efforts: (1) mapping and monitoring the distribution and condition of shrub steppe communities with local detail at a regional scale, (2) assessing the relationships between specific, land-use features (for example, roads, transmission lines, industrial pads) and invasive plants, including their potential (environmentally defined) distribution across the region, and (3) monitoring the effects of habitat treatments on the ecosystem, including wildlife use and invasive plant abundance. This research is focused on the northern sagebrush steppe, primarily in Wyoming, but also extending into Montana, Colorado, Utah and Idaho. The study area includes a range of sagebrush types (including, Artemisia tridentata ssp. tridentata, Artemisia tridentata ssp. wyomingensis, Artemisia tridentata ssp. vaseyana, Artemisia nova) and other semi-arid shrubland types (for example, Sarcobatus vermiculatus, Atriplex confertifolia, Atriplex gardneri), impacted by extensive interface between steppe ecosystems and industrial energy activities resulting in a revealing multiple-variable analysis. We use a combination of remote sensing (AWiFS (1 Any reference to platforms, data sources, equipment, software, patented or trade-marked methods is for information purposes only. It does not represent endorsement of the U.S.D.I., U.S.G.S. or the authors), Landsat and Quickbird platforms), Geographic Information System (GIS) design and data management, and field-based, replicated sampling to generate multiple scales of data representing the distribution of shrub communities for the habitat inventory. Invasive plant sampling focused on the interaction between human infrastructure and weedy plant distributions in southwestern Wyoming, while also capturing spatial variability associated with growing conditions and management across the region. In a separate but linked study, we also sampled native and invasive composition of recent and historic habitat treatments. Here, we summarize findings of this ongoing work, highlighting patterns and relationships between vegetation (native and invasive), land cover, landform, and land-use patterns in the sagebrush steppe.
Image reconstruction using spectroscopic and hyperspectral information for compressive terahertz imaging (2010)

Terahertz (THz) time-domain imaging is an emerging modality and has attracted a lot of interest. However, existing THz imaging systems often require a long scan time and sophisticated system design. Recently, a new design incorporating compressed sensing (CS) leads to a lower detector cost and shorter scan time, in exchange for computation in an image reconstruction step. In this paper, we develop two reconstruction algorithms that can estimate the underlying scene as accurately as possible. First is a single-band CS reconstruction method, where we show that by making use of prior information about the phase and the correlation between the spatial distributions of the amplitude and phase, the reconstruction quality can be significantly improved over previously published methods. Second, we develop a method that uses the multi-frequency nature of the THz pulse. Through effective use of the spatial sparsity, spectroscopic phase information, and correlations across the hyperspectral bands, our method can further enhance the recovered image quality. This is demonstrated by computation on a set of experimental THz data captured in a single-pixel THz system.
Detection and tissue localization of components of the immune complex in animals infected and immunized with influenza virus. (1979)

Mice previously vaccinated or convalescents after infection with mouse-adapted influenza virus were challenged by various routes with live or inactivated virus. The components of the immune complex (antigen-antibody-complement) could be detected by immunofluorescence in lungs, kidneys, and heart. The frequency of positive immunofluorescence reaction was related to serum antibody level and, to some extent, to the route the animals were challenged.
Exertional Rhabdomyolysis (2012)

In this review, the clinical and laboratory features of exertional rhabdomyolysis (ER) are discussed in detail, emphasizing the full clinical spectrum from physiological elevations of serum creatine kinase after exertion to life-threatening rhabdomyolysis with acute kidney injury and associated systemic complications. Laboratory markers used to diagnose both ER and rhabdomyolysis are very sensitive, but not very specific, and imperfectly distinguish "subclinical" or asymptomatic from severe, life-threatening illness. However, genetic factors, both recognized and yet to be discovered, likely influence this diverse clinical spectrum of disease and response to exercise. Genetic mutations causative for McArdle disease, carnitine palmitoyl transferase deficiency 2, myoadenylate deaminase deficiency, and malignant hyperthermia have all been associated with ER. Polymorphic variations in the myosin light chain kinase, α-actin 3, creatine kinase-muscle isoform, angiotensin I-converting enzyme, heat shock protein, and interleukin-6 genes have also been associated with either ER or exercise-induced serum creatine kinase elevations typical of ER. The prognosis for ER is significantly better than that for other etiologies of rhabdomyolysis, but the risk of recurrence after an initial episode is unknown. Guidelines for management are provided.
Measurement Methods of Moisture in Building Envelopes – A Literature Review∗ (2007)

This article reviews the methods, principles, and performances of moisture measurement in building envelopes with a focus on continuous monitoring applications. It compiles an extensive list of closely related literature. Brief examples are presented to demonstrate measurement values and a presentation approach for measured electric-resistance data. Moisture measurement methods have various capabilities. Some methods can quantify moisture content for some building materials such as timber, while also providing comparative values or changes in wetness conditions for other building materials. Other methods are used to warn of excessive wetness conditions in the envelope, particularly in hidden or difficult-to-access areas. Reviewed methods are grouped according to the measurement principle: for example, resistance, voltage, and thermal-based methods. Resistance and voltage-based sensors are most suitable for continuous monitoring applications as they can be readily connected to a data logging system. Voltage-based methods such as the Sereda and printed circuit sensors are usually used to indicate time-of-wetness of surfaces. Their main weakness is durability, which can be quite short in outdoor applications. Resistance-based methods, such as moisture pins, Duff sensors, and ceramic sensors, are used to monitor changes in moisture level within materials as well as time-of-wetness of surfaces. These sensors are durable and can be fabricated in-house.
Randomized Trials Built on Sand: Examples from COPD, Hormone Therapy, and Cancer (2012)

The randomized controlled trial is the fundamental study design to evaluate the effectiveness of medications and receive regulatory approval. Observational studies, on the other hand, are essential to address post-marketing drug safety issues but have also been used to uncover new indications or new benefits for already marketed drugs. Hormone replacement therapy (HRT) for instance, effective for menopausal symptoms, was reported in several observational studies during the 1980s and 1990s to also significantly reduce the incidence of coronary heart disease. This claim was refuted in 2002 by the large-scale Women's Health Initiative randomized trial. An example of a new indication for an old drug is that of metformin, an anti-diabetic medication, which is being hailed as a potential anti-cancer agent, primarily on the basis of several recent observational studies that reported impressive reductions in cancer incidence and mortality with its use. These observational studies have now sparked the conduct of large-scale randomized controlled trials currently ongoing in cancer. We show in this paper that the spectacular effects on new indications or new outcomes reported in many observational studies in chronic obstructive pulmonary disease (COPD), HRT, and cancer are the result of time-related biases, such as immortal time bias, that tend to seriously exaggerate the benefits of a drug and that eventually disappear with the proper statistical analysis. In all, while observational studies are central to assess the effects of drugs, their proper design and analysis are essential to avoid bias. The scientific evidence on the potential beneficial effects in new indications of existing drugs will need to be more carefully assessed before embarking on long and expensive unsubstantiated trials.
Velocity and mass flow rate profiles of dry powders in a gravity drop conveyor using an electrodynamic tomography system (1997)

This paper describes measurements made on a gravity drop conveyor using two arrays of axially spaced electrodynamic sensors to measure axial velocities close to the wall of the conveyor and velocity profiles both of flowing sand and of plastic beads. The level of correlation obtained using pixels is investigated. The velocity profile is combined with a tomographic concentration profile to estimate the mass flow profile, which is summed over the measurement cross section to estimate the mass flow rate. A calibration of the tomographically determined mass flow rate versus the actual mass flow rate is presented.
Terahertz imaging based on optical coherence tomography [Invited] (2014)

Three-dimensional (3D) terahertz (THz) imaging or THz tomography has recently proven to be useful for nondestructive testing of industrial materials and structures. In place of previous imaging techniques such as THz pulsed/continuous-wave radar and THz computed tomography, we propose a THz optical coherence tomography using photonics- and electronics-based THz sources, and demonstrate thickness measurement and tomographic imaging in frequency regions from 400 to 800 GHz.