gebhart/patrepeval huggingface dataset:
Experimental study on vehicle speed estimation using accelerometer and wheel speed measurements (2011)

Accurate estimation of longitudinal vehicle speed using general in-vehicle sensors like wheel speed sensors and accelerometers is crucial for good performance of vehicle dynamic control systems. Most of passenger vehicles are two-wheel drive, which provides speed measurement by wheel speed sensors of non-driven wheels. However, when wheels are under braking, this method is not reliable enough since wheels are at high level of slip. An alternative method is to use the direct integration of the longitudinal acceleration, but offset in the acceleration signal may cause excessive errors in estimation results. This work develops a speed estimation method using Kalman filtering algorithm by establishing an updating method of acceleration offset.
Advanced fabrication of metal–organic frameworks: template-directed formation of polystyrene@ZIF-8 core–shell and hollow ZIF-8 microspheres (2011)

The conjunction of porous ZIF-8 with polystyrene spheres is demonstrated to induce the formation of polystyrene@ZIF-8 core-shell structures. A subsequent etching process on polystyrene@ZIF-8 core-shells to remove polystyrene cores results in a unique hollow ZIF-8.
Pedestrian detection with near and far infrared night vision enhancement (2004)

"December 2004."
Improved two-step clock-feedthrough compensation technique for switched-current circuits (1998)

A new clock-feedthrough compensation scheme for switched-current circuits is proposed. The scheme is especially suited for the design of delay lines for high-frequency operation. The circuit operates by using an improved two-step technique, in which the input is sampled in a parallel combination of a coarse and a fine memory transistor. Since both transistors are of the same type, large switching transients compared to the conventional S/sup 2/I scheme can be avoided. Using the proposed circuit, the coarse memory has considerably more time to settle. Compared to the simple cell, the circuit solution requires only one extra switch and one additional clock phase.
Applications of proteomics in the study of inflammatory bowel diseases (2008)

Inflammatory bowel diseases (IBD) are chronic, heterogeneous, and multifactorial intestinal inflammatory disorders. Major challenges in IBD research include identification of major pathogenic alterations of genes/proteins as well as effective biomarkers for early diagnosis, prognosis, and prediction of therapeutic response. Since proteins govern cellular structure and biological function, a wide selection of proteomic approaches enables effective characterization of IBD pathogenesis by investigating the dynamic nature of protein expression, cellular and subcellular distribution, posttranslational modifications, and interactions at both the cellular and subcellular levels. The aims of this review are to 1) highlight the current status of proteomic studies of IBD, and 2) introduce the available and emerging proteomic technologies that have potential applications in the study of IBD. These technologies include various mass spectrometry technologies, quantitative proteomics (2D-PAGE, ICAT, SILAC, iTRAQ), protein/antibody arrays, and multi-epitope-ligand cartography. This review also presents information and methodologies, from sample selection and enrichment to protein identification, that are not only essential but also particularly relevant to IBD research. The potential future application of these technologies is expected to have a significant impact on the discovery of novel biomarkers and key pathogenic factors for IBD.
Myosin isoenzymes in normal and hypertrophied human ventricular myocardium. (1983)

We tested the hypothesis that hypertrophy of the human heart is associated with the redistribution of ventricular isomyosins. Human cardiac myosin was isolated from autopsy samples of left ventricular free wall of patients with cardiac hypertrophy and of fetal, young, and adult subjects without heart disease. The following parameters were studied: electrophoretic migration in denaturing and non-denaturing conditions; immunological cross-reactivities with three different types of antibodies; and early phosphate burst size and steady state ATPase activities stimulated by K+-EDTA, Ca++, Mg++, and actin. The antibodies were chosen for their ability to recognize selectively the rat V1 and V3 cardiac isomyosins. The first type was a monoclonal antibody, CCM-52, prepared against embryonic chick cardiac myosin, the second was an anti-beef atrial myosin, and the third was an anti-rat V1 myosin. CCM-52 reacted with a greater affinity with rat V3 than with rat V1, and was a probe of mammalian V3. Anti-beef atrial myosin and anti-rat V1 myosin both recognized specifically beef atrial and rat V1 myosins, and were thus considered as probes of mammalian V1. Under non-denaturing conditions, human myosins migrated as rat V3 isomyosin; under denaturing conditions, no difference was observed in any of the electrophoretic parameters between all samples tested, except for the fetal hearts which contained a fetal type of light chain. The immunological studies indicated that human myosins were composed mostly of a V3 type (HV3), but contained also some V1 isomyosin. A technique was developed to quantify the amount of human VI isomyosin which was found to range from almost 0 to 15% of total myosin, and to vary from one heart to the other, regardless of the origin of the heart. Enzymatic studies showed no significant difference between normal, hypertrophied, and fetal hearts in any of the activities tested. However, there was a significant correlation between Ca++-stimulated ATPase activities and HV1 amount (at 0.05 M KCl, n = 18, r2 equal 0.49, P less than 0.01; at 0.5 M KCl, n = 18, r 2 = 0.5, P less than 0.01). These data demonstrate the heterogeneity of human ventricular myosin, which appears to be composed, as in other mammalian species, of V1 and V3 isoforms of different ATPase activities (V1 greater than V3). However it seems that V1 to V3 shifts do not appear to be of physiological significance in the adaptation of human heart to chronic mechanical overloads.
Metastable Prepores in Tension-Free Lipid Bilayers (2018)

The formation and closure of aqueous pores in lipid bilayers is a key step in various biophysical processes. Large pores are well described by classical nucleation theory, but the free-energy landscape of small, biologically relevant pores has remained largely unexplored. The existence of small and metastable "prepores" was hypothesized decades ago from electroporation experiments, but resolving metastable prepores from theoretical models remained challenging. Using two complementary methods-atomistic simulations and self-consistent field theory of a minimal lipid model-we determine the parameters for which metastable prepores occur in lipid membranes. Both methods consistently suggest that pore metastability depends on the relative volume ratio between the lipid head group and lipid tails: lipids with a larger head-group volume fraction (or shorter saturated tails) form metastable prepores, whereas lipids with a smaller head-group volume fraction (or longer unsaturated tails) form unstable prepores.
A chemical and mechanistic view of reaction profiles in laser direct-write metallization in metallo-organic films. Gold. (1986)

Laser direct-write metallization in metallo-organic films involves complex thermal profiles and changes in optical properties that affect the spatial resolution, chemical purity, and electrical properties of the resulting features. Compositional profiles of the metal features, determined by scanning Auger electron spectroscopy, are reported and correlated with the chemistry of the laser-initiated thermal reaction and the observed feature structure. Studies of the changes in optical properties of the films by conventional thermal decomposition offer important insights into the reaction mechanisms. We also report an optimized development procedure for the laser-exposed samples.
Studies on quantitative physiology of <i>Trichoderma reesei</i> with two‐stage continuous culture for cellulose production (1979)

Abstract By employing a two‐stage continuous‐culture system, some of the more important physiological parameters involved in cellulose biosynthesis have been evaluated with an ultimate objective of designing an optimally controlled cellulose process. The two‐stage continuous‐culture system was run for a period of 1350 hr with Trichoderma reesei strain MCG‐77. The temperature and pH were controlled at 32°C and pH 4.5 for the first stage (growth) and 28°C and pH 3.5 for the second stage (enzyme production). Lactose was the only carbon source for the both stages. The ratio of specific uptake rate of carbon to that of nitrogen, Q (C)/ Q (N), that supported good cell growth ranged from 11 to 15, and the ratio for maximum specific enzyme productivity ranged from 5 to 13. The maintenance coefficients determined for oxygen, M O , and for carbon source, M C , are 0.85 mmol O 2 /g biomass/hr and 0.14 mmol hexose/g biomass/hr, respectively. The yield constants determined are: Y X/O = 32.3 g biomass/mol O 2 , Y X/C = 1.1 g biomass/g C or Y X/C = 0.44 g biomass/g hexose, Y X/N = 12.5 g biomass/g nitrogen for the cell growth stage, and Y X/N = 16.6 g biomass/g nitrogen for the enzyme production stage. Enzyme was produced only in the second stage. Volumetric and specific enzyme productivities obtained were 90 IU/liter/hr and 8 IU/g biomass/hr, respectively. The maximum specific enzyme productivity observed was 14.8 IU/g biomass/hr. The optimal dilution rate in the second stage that corresponded to the maximum enzyme productivity was 0.026 ∼ 0.028 hr −1 , and the specific growth rate in the second stage that supported maximum specific enzyme productivity was equal to or slightly less than zero.
Compact Microstrip Sensor For High Moisture Content Materials (1979)

A compact form of stripline sensor has been developed which is robust in construction and suitable for measuring moisture contents up to 100% (wet basis). It offers potential for further miniaturisation of microwave moisture meter circuitry.
Molecular Cloning and Characterization of a Soluble Inorganic Pyrophosphatase in Potato (1995)

A cDNA clone encoding a soluble inorganic pyrophosphatase (EC 3.6.1.1) of potato (Solanum tuberosum L.) was isolated by screening a developing tuber library with a heterologous probe. The central domain of the encoded polypeptide is nearly identical at the sequence level with its Arabidopsis homolog (J.J. Kieber and E.R. Signer [1991] Plant Mol Biol 16: 345-348). Computer-assisted analysis of the potato, Arabidopsis, and Escherichia coli soluble pyrophosphatases indicated a remarkably conserved organization of the hydrophobic protein domains. The enzymatic function of the potato protein could be deduced from the presence of amino acid residues highly conserved in soluble pyrophosphatases and was confirmed by its capacity to complement a thermosensitive pyrophosphatase mutation in E. coli. The potato polypeptide was purified from complemented bacterial cells and its pyrophosphatase activity was shown to be strictly dependent on Mg2+ and strongly inhibited by Ca2+. The subcellular location of the potato pyrophosphatase is unknown. Structure analysis of the N-terminal protein domain failed to recognize typical transit peptides and the calculated molecular mass of the polypeptide (24 kD) is significantly inferior to the values reported for the plastidic (alkaline) or mitochondrial pyrophosphatases in plants (28-42 kD). Two unlinked loci could be mapped by restriction fragment length polymorphism analysis in the potato genome using the full-length cDNA as probe.
Reserve carbohydrates metabolism in the yeast<i>Saccharomyces cerevisiae</i> (2001)

Glycogen and trehalose are the two glucose stores of yeast cells. The large variations in the cell content of these two compounds in response to different environmental changes indicate that their metabolism is controlled by complex regulatory systems. In this review we present information on the regulation of the activity of the enzymes implicated in the pathways of synthesis and degradation of glycogen and trehalose as well as on the transcriptional control of the genes encoding them. cAMP and the protein kinases Snf1 and Pho85 appear as major actors in this regulation. From a metabolic point of view, glucose-6-phosphate seems the major effector in the net synthesis of glycogen and trehalose. We discuss also the implication of the recently elucidated TOR-dependent nutrient signalling pathway in the control of the yeast glucose stores and its integration in growth and cell division. The unexpected roles of glycogen and trehalose found in the control of glycolytic flux, stress responses and energy stores for the budding process, demonstrate that their presence confers survival and reproductive advantages to the cell. The findings discussed provide for the first time a teleonomic value for the presence of two different glucose stores in the yeast cell.
Novel patient-specific navigational template for total knee arthroplasty (2011)

Current techniques for total knee arthroplasty have certain drawbacks, including violation of the intramedullary canals and limited accuracy. The aim of this research was to develop and validate the accuracy of a new computer-assisted preoperative planning concept for the creation of patient-specific navigational templates to replace conventional instruments. Volumetric computerized tomography (CT) scanning was performed on 30 cadaveric knees, and a three-dimensional reconstruction model of each knee was generated from the scan data. Using a reverse-engineering technique, optimal lower-limb alignment and rotational alignment were determined. A navigational template was also designed with a surface that matched the distal femur and proximal tibia. This template, with its corresponding femur and tibia, was manufactured using a rapid-prototyping technique and tested for violations. The navigational template was then used intraoperatively to assist with an arthroplasty in each of the 30 cadaveric knees. Following surgery, the positions of the prostheses were evaluated with X-rays and CT scans. The method showed a high degree of accuracy and reproducibility. In all cases, placing the template manually on the lamina of the femur and tibia was relatively easy. Twenty-eight prostheses were considered to be positioned entirely accurately, whereas two prostheses were considered to have a 1-2° malpositioning. This study thus introduces a novel navigational template for total knee arthroplasty. Preliminary cadaveric trials have demonstrated that this design can improve the accuracy of osteotomy in the surgical procedure.
Fluid flow and stability of the US continental slope offshore New Jersey from the Pleistocene to the present (2002)

Abstract We predict that portions of the New Jersey continental slope were unstable approximately 0.5 million years ago. This instability was caused by rapid sediment loading during a Pleistocene sea‐level lowstand and by flow focusing in underlying, permeable Miocene strata. The simulated instability is consistent with soft‐sediment deformation and small slumps in Pleistocene strata of the Hudson Apron. Stability of the New Jersey margin has increased since 0.3 Ma because sedimentation rate has decreased. Today, the modelled factor of safety (FS) for the upper slope is approximately 1.5 whereas in the lower slope it exceeds 3. We predict that sedimentation rate is a dominant factor on slope stability. When rapid and asymmetric loading of a highly permeable sedimentary layer occurs, the location of instability can shift seaward to regions where sedimentation rates are low. Stability calculations use pressures and effective stresses predicted by a coupled sedimentation‐fluid flow model. This hydrodynamic analysis demonstrates how the interplay of sedimentation and fluid migration affects the distribution, timing, and size of sedimentary failures.
Protein adsorption and platelet attachment and activation, on TiN, TiC, and DLC coatings on titanium for cardiovascular applications (2000)

The hemocompatibility of a TiN/TiC/diamond-like carbon (DLC) multilayer structure, deposited on titanium substrates for use as coatings for a heart valve prosthesis, has been studied through the adsorption of blood proteins and the adhesion and attachment of blood platelets. All of the surfaces were characterized by stylus profilometry and water contact angles. The adsorption of albumin and fibrinogen to the surfaces was assessed using the Amido Black assay, whereas platelet attachment was studied by scanning electron microscopy and quantified using stereological techniques. The degree of platelet spreading on the surfaces was seen to correlate with differences in surface energy, indicated from contact angle measurements. The greatest spreading was seen on the more hydrophilic surfaces. When studying protein adsorption to the surfaces, no correlation could be determined between contact angle results and levels of adsorption, although the most hydrophilic surfaces did appear to promote greater amounts of fibrinogen adsorption. Thrombus formation was observed to some degree on all of the surfaces, with the exception of the DLC coating. This coating also promoted less spreading of platelets than the other surfaces. The good hemocompatibility of the DLC coating is attributed to its hydrophobicity and smooth surface, resulting in a higher ratio of albumin to fibrinogen than any of the other surfaces.
Design considerations of electrostatic forces in microaccelerometers (2003)

Micromechanical accelerometers are microscale sensors, whose operating principles and design theories are similar to those of conventional accelerometers. However, surface forces between mechanical structures become more important factors that affect the performance as microstructural size decreases. This paper discusses the effects of the electrostatic forces on the performance of open- and closed- loop micromechanical accelerometers, which are stiffness and damping change, and difference of the transfer function of the system.
Stereo-Based Pedestrian Detection for Collision-Avoidance Applications (2009)

Pedestrians are the most vulnerable participants in urban traffic. The first step toward protecting pedestrians is to reliably detect them. We present a new approach for standing- and walking-pedestrian detection, in urban traffic conditions, using grayscale stereo cameras mounted on board a vehicle. Our system uses pattern matching and motion for pedestrian detection. Both 2-D image intensity information and 3-D dense stereo information are used for classification. The 3-D data are used for effective pedestrian hypothesis generation, scale and depth estimation, and 2-D model selection. The scaled models are matched against the selected hypothesis using high-performance matching, based on the Chamfer distance. Kalman filtering is used to track detected pedestrians. A subsequent validation, based on the motion field's variance and periodicity of tracked walking pedestrians, is used to eliminate false positives.
POVA: Traffic Light Sensing with Probe Vehicles (2012)

Traffic light sensing aims to detect the status of traffic lights which is valuable for many applications such as traffic management, traffic light optimization, and real-time vehicle navigation. In this work, we develop a system called POVA for traffic light sensing in large-scale urban areas. The system employs pervasive probe vehicles that just report real-time states of position and speed from time to time. POVA has advantages of wide coverage and low deployment cost. The important observation motivating the design of POVA is that a traffic light has a considerable impact on mobility of vehicles on the road attached to the traffic light. However, the system design faces three unique challenges: 1) Probe reports are by nature discrete while the goal of traffic light sensing is to determine the state of a traffic light at any time; 2) there may be a very limited number of probe reports in a given duration for traffic light state estimation; and 3) a traffic light may change its state with a variable interval. To tackle the challenges, we develop a new technique that makes the best use of limited probe reports as well as statistical features of light states. It first estimates the state of a traffic light at the time instant of a report by applying maximum a posterior estimation. Then, we formulate the state estimation of a light at any time into a joint optimization problem that is solved by an efficient heuristic algorithm. We have implemented the system and tested it with a fleet of around 4,000 probe taxis and 2,000 buses in Shanghai, China. Trace-driven experimentation and field study show that nearly 60 percent of traffic lights have an estimation error lower than 19 percent if 20,000 probe vehicles would be employed in the urban area of Shanghai. We further demonstrate that the estimation error rate is as low as 18 percent even when the number of available reports is merely 1 per minute.
3-D object pose estimation based on iterative image matching: Shading and edge data fusion (1996)

Based on model-driven image matching, the 3-D object pose is iteratively estimated. Shading images and edge images are synthesized from an abject model, and are matched, individually, with the input images by using a nonlinear least-squares method. The fusion of the shading and the edge information is achieved choosing the better of the two pieces of image matching.
Intraoperative Ultrasound Is Associated With Clear Lumpectomy Margins for Palpable Infiltrating Ductal Breast Cancer (2001)

The use of ultrasound-guided surgery optimizes the surgeon's ability to obtain satisfactory margins for breast-conserving techniques in patients with breast cancer. Patient satisfaction is excellent and a cost savings is most likely realized.
ChemInform Abstract: Highly Regioselective Intramolecular Hydroxymethylation of α,. beta.‐Unsaturated Carboxylic Acids. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Oncolytic Virus and Anti–4-1BB Combination Therapy Elicits Strong Antitumor Immunity against Established Cancer (2012)

Oncolytic virotherapy using vaccinia virus (Vv) has shown some encouraging antitumor responses in mouse models and patients, but the breadth of efficacy in clinical trials has been somewhat limited. Given that antitumor effects have correlated with increased host immune responses, we hypothesized that improved therapeutic outcomes may be achieved by using oncolytic virus (OV) in combination with a potent immune agonist reagent. In this study, we carried out a preclinical evaluation of a genetically engineered strain of oncolytic vaccinia virus (Vvdd) for its capacity to induce antitumor responses when combined with an agonist antibody (Ab) specific for the costimulatory molecule 4-1BB (CD137). In immune-competent syngeneic mouse models of cancer, this combination therapy significantly reduced the growth of established subcutaneous tumors relative to either treatment alone. Importantly, the development of pulmonary metastatic lesions was also reduced. Tumor growth inhibition was associated with increased numbers of CD11b(+) and CD11c(+) myeloid cells in the tumor draining lymph nodes, greater infiltration of CD8(+) effector T and natural killer (NK) cells, and a more sustained presence of neutrophils at the tumor site. Depletion of T or NK cells or neutrophils reduced efficacy, confirming their contribution to an effective therapeutic response. We further extended this conclusion through results from IFNγ-deficient mice. In summary, our findings offered a proof-of-concept for a combinatorial approach to enhance the antitumor efficacy of an OV, suggesting a strategy to improve their use as an immunotherapeutic treatment for cancer.