gebhart/patrepeval huggingface dataset:
An NMR, IR and theoretical investigation of <sup>1</sup>H Chemical Shifts and hydrogen bonding in phenols (2007)

The change in (1)H NMR chemical shifts upon hydrogen bonding was investigated using both experimental and theoretical methods. The (1)H NMR spectra of a number of phenols were recorded in CDCl(3) and DMSO solvents. For phenol, 2- and 4-cyanophenol and 2-nitrophenol the OH chemical shifts were measured as a function of concentration in CDCl(3). The plots were all linear with concentration, the gradients varying from 0.940 (phenol) to 7.85 (4-cyanophenol) ppm/M because of competing inter- and intramolecular hydrogen bonding. Ab initio calculations of a model acetone/phenol system showed that the OH shielding was linear with the H...O=C distance (R) for R < 2.1 A with a shielding coefficient of - 7.8 ppm/A and proportional to cos(2)phi where phi is the H...O=C--C dihedral angle. Other geometrical parameters had little effect. It was also found that the nuclear shielding profile is unrelated to the hydrogen bonding energy profile. The dependence of the OH chemical shift on the pi density on the oxygen atom was determined as ca 40 ppm/pi electron. This factor is similar to that for NH but four times the value for sp(2) hybridized carbon atoms. The introduction of these effects into the CHARGE programme allowed the calculation of the (1)H chemical shifts of the compounds studied. The CHARGE calculations were compared with those from the ACD database and from GIAO calculations. The CHARGE calculations were more accurate than other calculations both when all the shifts were considered and also when the OH shifts were excluded. The calculations from the ACD and GIAO approaches were reasonable when the OH shifts were excluded but not as good when all the shifts were considered. The poor treatment of the OH shifts in the GIAO calculations is very likely due to the lack of explicit solvent effects in these calculations.
ENTRE TRACOS, ENTRE LACOS: (RE)CONFIGURACOES DO CORPO E DO HOMOEROTISMO FEMININO NA NARRATIVA BRASILEIRA CONTEMPORANEA (2014)

Proponho, nesse artigo, a discussão e análise acerca da (re)configuração literária e discursiva do corpo feminino em dois contos do escritor Marcelino Freire. Os traços e os laços que configuram a representação de relações homoeróticas nos contos Minha flor (2003) e Declaração (2010) repercutem não somente o tema da lesbianidade na narrativa contemporânea brasileira quanto indagam entrelaçamentos discursivos de poder e silenciamento do amor que, atualmente, já ousa dizer seu nome. Assim como, busco salientar que tais narrativas (re)configuram a construção do corpo dentro das relações homoafetivas distintamente de narrativas literárias que as precederam
METOCLOPRAMIDE (1983)

Steven D. Reich, M.D., is Associate Professor of the Departments of Medicine and Pharmacology at the University of Massachusetts Medical Center, Worcester, Massachusetts.
Interaction of Orally Administered 5-{3-[((25)-1,4-Benzodioxan-2-ylmethyl)amino]propoxy}-1,3-benzodioxole (MKC-242) with 5-HT1A Receptors in Rat Brain (1997)

The present study was carried out to clarify whether orally administered 5-{3-[((25)-1,4-benzodioxan-2-ylmethyl)amino]propoxy}-l,3-benzodioxole (MKC-242), a serotonin1A (5-HTiA)-receptor agonist having potent anxiolytic-like and antidepressant-like effects in animal models, binds to 5-HTiA receptors in rat brain. Quantitative autoradiography showed that orally administered MKC-242 (0.1-0.5 mg/kg) caused a significant decrease in [3H]8-hydroxy-2-(di-h-propylamino)tetralin (8-OH-DPAT) binding in the hippocampus and dorsal raphe nucleus sections. The decrease in the binding by MKC-242 was observed up to 4 hr after administration, and the effective doses were similar to those in its anxiolytic-like effect in the animal models. Repeated treatment of MKC-242 (0.5 mg/kg/day, p.o.) or buspirone (30 mg/kg/day, p.o.) for 2 weeks did not affect [3H]8-OH-DPAT binding in both sections. These results suggest that orally administered MKC-242 at the low doses that do not show 5-HTiA-receptor-mediated in vivo responses such as the hypothermic effect, adrenocortical effect and the decrease in 5-HT turnover passes the blood-brain barrier and subsequently binds to 5-HT1A receptors in rat brain. In addition, they indicate that repeated stimulation of the receptors by the agonists does not affect the number of the binding sites.
Regulation of mammary gland factor/Stat5a during mammary gland development. (1995)

The rat homolog of sheep mammary gland factor (MGF)/Stat5 has been isolated and used to study the regulation of Stat5 during mammary gland development and PRL regulation in COS cells transfected with Stat5a and the PRL receptor. Two alternatively spliced isoforms, designated Stat5a1 and Stat5a2, were identified, the latter encoding a carboxy-terminal truncated protein. A polyclonal antibody to a carboxy-terminal peptide of Stat5a1 was generated and used to measure the level of this isoform during mammary gland development and after PRL induction in COS cells transiently transfected with Stat5a and the long form of the PRL receptor. Surprisingly, Stat5a mRNA and protein were readily detected both in virgin rats and after mammary gland involution. The levels of Stat5a increased during pregnancy, were highest in late pregnancy, and then, unexpectedly, decreased during lactation, the time at which the highest levels of milk protein gene expression are observed. Electrophoretic mobility shift assays using the specific anti-Stat5a1 antisera demonstrated that Stat5a1 comprises part of the heterogeneous, PRL-inducible, protein-DNA complex associated with the beta-casein GAS site. Immunocytochemical analysis detected considerable cytoplasmic and some nuclear staining for Stat5a1 during late pregnancy and predominantly nuclear staining during early lactation. The lack of correspondence of Stat5a gene expression and beta-casein gene expression suggests that Stat5 activation may facilitate the interaction of other factors binding within composite response elements identified recently in the milk protein gene promoters that are then responsible for the stable expression of milk protein genes in terminally differentiated mammary epithelial cells.
Effect of Posture on Popliteal Artery Hemodynamics (2000)

Lower limb arterial vFl, mean velocity, peak systolic velocity, and EDV decrease significantly (P<.001) when posture is altered from recumbency to sitting, in normal subjects and in patients with intermittent claudication. A decrease in the EDV and an increase in the pulsatility index on sitting indicate enhancement of arterial resistance to flow secondary to peripheral vasoconstriction. Quantitative differences between the groups in vFl (P<.04), EDV (P<.01), and pulsatility index (P<.001) on dependency indicate that the orthostatic vasoactive response in patients with intermittent claudication is significantly subdued, reflecting a marked derangement in venoarteriolar response.
The Ras superfamily of GTPases <sup>1</sup> (1996)

The Ras superfamily of small GTPases comprises a group of molecular switches that regulate an astonishing diversity of cellular functions. A deep understanding of mitogenesis, cytoskeletal organization, vesicle traffic, and nuclear transport now requires the inclusion of the small GTPases as essential components of the molecular machines that drive these processes. The rich complexity of the control mechanisms involved is evidenced by the recent discoveries of GTPase cascades, multiple downstream effectors, and interconnected networks of GTPase-regulated protein kinase cascades. The 1995 FASEB Summer Conference at Snowmass Village, Colorado, on the Ras GTPase superfamily provided testimony to the broad impact that the study of these proteins continues to exert on cell biology.
OPASYN: a compiler for CMOS operational amplifiers (1990)

A silicon compilation system for CMOS operational amplifiers (OPASYN) is discussed. The synthesis system takes as inputs system-level specifications, fabrication-dependent technology parameters, and geometric layout rules. It produces a design-rule-correct compact layout of an optimized operational amplifier. The synthesis proceeds in three stages: (1) heuristic selection of a suitable circuit topology; (2) parametric circuit optimization based on analytic models; and (3) mask geometry construction using a macro cell layout style. The synthesis process is fast enough for the program to be used interactively at the system design level by system designers who are inexperienced in operational amplifier design.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Time evolution of a broadband quasi-cw dye laser: limitations of sensitivity in intracavity laser spectroscopy (1985)

The time-dependent properties of the wavelength-dispersed spectrum for a quasi-cw dye laser were measured (1) to define the operating criteria required for the quantitative application of intracavity laser spectroscopy (ILS) for absorption and (2) to determine the origin of the sensitivity limitations observed in several studies. Time-resolved and wavelength-dispersed spectra of a broadband dye laser were measured as a function of pumping power and of stability of the optical path length of the resonator cavity. The results of this study confirm that quantitative absorption measurements can be readily obtained by ILS and that the sensitivity of ILS detection derives from the overall stability of the dye laser, but especially that of its optical path length.
Es un momento oportuno. (2009)

La crisis actual tiene mcuhas facetas, pero probablemente su punto de partida es una vertiente etica y cultural.
Identification and Characterization of a Novel Member of the EXT Gene Family, EXTL2 (1997)

Recently, two homologous genes, EXT1 and EXT2, with a putative tumor suppressor function have been described. Mutations in both genes are responsible for multiple exostosis syndrome (EXT), an autosomal dominant condition characterized by the presence of multiple osteochondromas, bony excrescences that sometimes undergo malignant transformation to chondrosarcoma. This family of EXT genes has been extended by the identification of an EXT- like (EXTL) gene showing a high degree of homology with the EXT genes. We report here a second EXT-like gene (EXTL2) which is homologous to the EXT and EXTL genes. EXTL2 consists of 5 exons encoding an ubiquitously expressed protein of 330 amino acids. In addition, a putative pseudogene, EXTL2P was also identified. The EXTL2 gene was assigned to chromosome 1p11-p12, whereas EXTL2P was mapped on chromosome 2q24-q31.
Efficacy and Safety of Iguratimod for the Treatment of Rheumatoid Arthritis (2013)

All randomized controlled trials (RCTs) of iguratimod for rheumatoid arthritis (RA) to assess its efficacy and safety are included in this paper. The Review Manager software was used for meta-analysis to assess risk bias of the studies included, and GRADE profiler software was used for the evidence quality of the studies included. Four RCTs involving 1407 patients with RA were included. Meta-analyses showed that, after 24-week therapy, ACR20, tender joint count, swollen joint count, rest pain, physician and patient global assessment of disease activity, HAQ score, ESR, and CRP in iguratimod group were better than those in placebo group and that the difference between those of iguratimod group and those of other DMARDs (MTX and SASP) group was not significant. GRADE evidence classification of the studies included was moderate. Iguratimod for RA had few adverse events, and its efficacy and safety were the same as those of MTX and SASP for RA. The results of this systematic review suggest that more high-quality and large-scaled RCTs were needed to determine the efficacy of iguratimod for RA and whether iguratimod is as effective as other DMARDs besides MTX and SASP.
On the nonradiative and radiative decay rates and a modified exponential energy gap law for 4<i>f</i>–4<i>f</i> transitions in rare-earth ions (1983)

A modified exponential energy gap law for nonradiative decay has been derived for 4f–4f transitions where only a few phonons participate in the transition. Its preexponential factor varies by only a factor of 10 for different host materials and is purely electronic in nature. The modified law is the usual law (giving a factor of 105 variation) modified by using an energy gap which is effectively two (maximum) phonon energies smaller than the energy difference between the initial and the final electronic state. A general relation between the radiative and nonradiative decay rates has been constructed. For 4f–4f transitions this relation enables one to predict the nonradiative decay rate from a knowledge of the radiative decay rate to within one order of magnitude accuracy.
The preparation of <i>N</i>‐carboalkoxypyrazoles and <i>N</i>‐phenylpyrazoles from C(α)‐dianions of carboalkoxyhydrazones and phenylhydrazones (1987)

Abstract The 1,4‐dianions of C(α), N ‐carboalkoxyhydrazones and C(α), N ‐phenylhydrazones were prepared in an excess of lithium diisopropylamide (LDA). These dilithiated intermediates resulted from metalation of substituted hydrazones of several all‐aliphatic cyclic ketones, aliphatic‐aromatic cyclic ketones phenylacetaldehyde, and several substituted propiophenones or acetophenones. The esters utilized for Claisen‐type condensations of these dianion intermediates included methyl salicylate, methyl p ‐hydroxybenzoate, methyl nicotinate and related materials. The condensations were followed by acid‐cyclizations to give a variety of N ‐phenylpyrazoles and N ‐carboalkoxypyrazoles, most of which are new.
Machine Theory of Mind (2018)

Theory of mind (ToM; Premack & Woodruff, 1978) broadly refers to humans' ability to represent the mental states of others, including their desires, beliefs, and intentions. We propose to train a machine to build such models too. We design a Theory of Mind neural network -- a ToMnet -- which uses meta-learning to build models of the agents it encounters, from observations of their behaviour alone. Through this process, it acquires a strong prior model for agents' behaviour, as well as the ability to bootstrap to richer predictions about agents' characteristics and mental states using only a small number of behavioural observations. We apply the ToMnet to agents behaving in simple gridworld environments, showing that it learns to model random, algorithmic, and deep reinforcement learning agents from varied populations, and that it passes classic ToM tasks such as the "Sally-Anne" test (Wimmer & Perner, 1983; Baron-Cohen et al., 1985) of recognising that others can hold false beliefs about the world. We argue that this system -- which autonomously learns how to model other agents in its world -- is an important step forward for developing multi-agent AI systems, for building intermediating technology for machine-human interaction, and for advancing the progress on interpretable AI.
Ferrimagnetic mixed-spin ladders in weak- and strong-coupling limits (2004)

We study two similar spin ladder systems with the ferromagnetic leg coupling. The first model includes two sorts of spins $s=1∕2$ and 1, and the second model comprises only $s=1∕2$ legs coupled by a ``triangular'' rung exchange. We show that the antiferromagnetic (AF) rung coupling destroys the long-range order and eventually makes the systems equivalent to the AF $s=1∕2$ Heisenberg chain. We study the crossover from the weak- to strong-coupling regime by different methods, particularly by comparing the results of the spin-wave theory and the bosonization approach. We argue that the crossover regime is characterized by the gapless spectrum and nonuniversal critical exponents are different from those in $XXZ$ model.
Further studies of the chemical composition of the lipopolysaccharide of <i>Pseudomonas aeruginosa</i> (1972)

1. Qualitative and quantitative analytical results for the lipopolysaccharide from acetone-dried cells of Pseudomonas aeruginosa (N.C.T.C. 1999) are presented and possible contamination of the material with nucleic acid was further examined. 2. Additional sugars detected (only in large-scale hydrolysates) were mannose and arabinose; traces of spermidine and putrescine were also found. 3. The heptose component is l-glycero-d-mannoheptose. 4. The thiobarbituric acid-positive component is a 3-deoxy-2-octulonic acid, of which only 35-40% links lipid A to the polysaccharide. This linkage is not broken by hydrolysis with acetic acid up to 0.08m. 5. Liberation of lipid A required hydrolysis with 0.1m-hydrochloric acid, which substantially degraded the polysaccharide moiety. 6. Fractions obtained from the degraded polysaccharide by high-voltage electrophoresis were examined; in these, the alanine/galactosamine molar ratio is approx. 1. 7. Hydrazinolysis of whole lipopolysaccharide showed that at least 40% of the alanine is in amide linkage, possibly with galactosamine. 8. Lipid A, solubilized by alkaline methanolysis was fractionated; most of the phosphorus of the higher-molecular-weight fractions was released as P(i) by a phosphomonoesterase. 9. Hydrazinolysis of lipid A destroyed approx. 80% of the glucosamine, and glycosidically linked glucosamine oligosaccharides could not be isolated.
Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease (2014)

Thus, we propose that Aβ activation of mGluR5 appears to initiate a positive feedback loop resulting in increased Aβ formation and AD pathology in APPswe/PS1ΔE9 mice via mechanism that is regulated by FMRP.
Ciris (1925)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Micromachining and microfabrication (1997)

Micromachining and trends for the 21st century wet chemical etching of silicon and SiO2 issues in dry etching plating techniques high aspect ratio processing sensors and actuators micro-optical devices biomedical devices smart materials, MEMs and electronics integration.
Caplacizumab: First Global Approval (2018)

Ablynx, a Sanofi Company, has developed the anti-von Willebrand factor Nanobody<sup>®</sup> caplacizumab (Cablivi™) for the treatment of acquired thrombotic thrombocytopenic purpura (aTTP). Based on positive results in phase II and III trials in patients with aTTP, caplacizumab was recently approved in the EU for the treatment of adults experiencing an episode of aTTP, in conjunction with plasma exchange and immunosuppression. This article summarizes the milestones in the development of caplacizumab leading to this first approval.
Protein arginine methyltransferase 1 regulates hepatic glucose production in a FoxO1-dependent manner (2012)

Our data strongly suggest that the PRMT1-dependent regulation of FoxO1 is critical in hepatic glucose metabolism in vivo.
Linked sensor data: RESTfully serving RDF and GML (2009)

Publishing sensor observations on the Linked Data web is the first step in enabling the development of semantic web applications and mashups that can utilise sensor data. We present the design for a prototype API exposing data from the Channel Coastal Observatory in the UK. By combining REST and Linked Data principles we support both Semantic Web clients, OGC GML clients, and hybrid applications that can transpose between these, and other, representations.
Stereoselective Hydride Reductions of Cyclic α,β-Unsaturated <i>N</i>-Diphenylphosphinyl Imines to Protected Allylic Amines (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTStereoselective Hydride Reductions of Cyclic α,β-Unsaturated N-Diphenylphosphinyl Imines to Protected Allylic AminesRobert O. Hutchins, Samala J. Rao, Jeffrey Adams, and HutchinsView Author Information Department of Chemistry, Drexel University, Philadelphia, Pennsylvania 19104 Cite this: J. Org. Chem. 1998, 63, 22, 8077–8080Publication Date (Web):October 2, 1998Publication History Received25 June 1998Published online2 October 1998Published inissue 1 October 1998https://doi.org/10.1021/jo9812429Copyright © 1998 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views596Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (84 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amines,Anions,Reaction products,Reagents,Redox reactions Get e-Alerts
Fruit Surface Colonization and Biological Control of Postharvest Diseases of Pear by Preharvest Yeast Applications (1999)

The yeasts Cryptococcus infirmo-miniatus, Cryptococcus laurentii, and Rhodotorula glutinis, applied to Bosc and d'Anjou pear fruit in the field 3 weeks prior to harvest, maintained high population levels through harvest, while populations of Candida oleophila declined after 1 and 2 weeks, and by harvest were not significantly different from total yeast populations on untreated fruit. Yeasts were sprayed individually on fruit at concentrations of 1 to 3 × 10 8 CFU/ml, with approximately 2 ml applied per fruit. Initial population sizes for all four species averaged 5 × 10 6 CFU per fruit. C. infirmo-miniatus provided the most consistent decay control in fruit treated 3 weeks before harvest. C. infirmo-miniatus and R. glutinis also provided significant postharvest decay control in Bosc fruit treated 1 day before harvest.
Presentation of Phagocytosed Antigens by <scp>MHC</scp> Class I and <scp>II</scp> (2012)

Phagocytosis provides innate immune cells with a mechanism to take up and destroy pathogenic bacteria, apoptotic cells and other large particles. In some cases, however, peptide antigens from these particles are preserved for presentation in association with major histocompatibility complex (MHC) class I or class II molecules in order to stimulate antigen-specific T cells. Processing and presentation of antigens from phagosomes presents a number of distinct challenges relative to antigens internalized by other means; while bacterial antigens were among the first discovered to be presented to T cells, analyses of the cellular mechanisms by which peptides from phagocytosed antigens assemble with MHC molecules and by which these complexes are then expressed at the plasma membrane have lagged behind those of conventional model soluble antigens. In this review, we cover recent advances in our understanding of these processes, including the unique cross-presentation of phagocytosed antigens by MHC class I molecules, and in their control by signaling modalities in phagocytic cells.
Effects of surgery and chronic disease states on the concentrations and phenotype distribution of α1-acid glycoprotein: studies in patients with breast cancer and patients with chronic inflammatory disease (2011)

The F1/S variants of AGP, but not the A variant, were significantly increased after early breast cancer surgery, but all the variants were increased in patients with chronic inflammatory states such as RA and SLE. The distribution of the AGP phenotypes did not differ significantly among the disease groups studied.