gebhart/patrepeval huggingface dataset:
High-Level Expression of Human Lactoferrin in Milk of Transgenic Mice Using Genomic Lactoferrin Sequence (1999)

In our previous study, transgenic mice were generated that expressed human lactoferrin (hLF) in milk using cDNA under control of the 2 kb bovine beta-casein promoter. The expression level of the protein in milk of 7 mice ranged from 1 to 200 microg/ml; 1 to 34 microg/ml in 6 mice and 200 microg/ml in 1 mouse. With the aim of inducing higher expression of the protein, we constructed an expression cassette comprised of 10 kb of the bovine beta-casein gene promoter and the hLF genomic sequence in place of the cDNA. The hLF genomic sequence of about 27 kb, spanning 23 kb of the entire coding region and 4 kb of the 3'-flanking sequence, was placed downstream the bovine beta-casein promoter. In total, 8 transgenic mice were generated from 31 mice (transgenic rate of 25.8%) born from the embryos microinjected with the 40-kb hLF expression cassette. Mammary-specific expression of the transgene was addressed by performing Northern hybridization of the total RNAs from various tissues of transgenic mice. Immunoblot analysis showed that the recombinant protein expressed in milk has the same molecular weight as the native protein. The amount of the protein in milk of 5 mice ranged from 60 to 6,600 microg/ml when judged by ELISA analysis. Three mice expressed the protein at the level higher than 500 microg/ml. These data suggest that the genomic lactoferrin sequence represents a valuable element for the efficient expression of the protein in milk of transgenic animals.
Identification of Suitable Ignition Conditions for Stable Switch from SI to HCCI of a Blowdown Supercharged Engine (2013)

In this paper, the necessary in-cylinder conditions for the transition from spark ignion (SI) to homogeneous charge compression ignition (HCCI) are analyzed. The hereby important factors for ignition time are investigated analytically. A control oriented combustion model, that is validated by experimental data, is used for sensivity analysis and a Monte-Carlo approach is taken to identify the important factors for transient HCCI and combustion mode switch. As a result, it was shown that the in-cylinder temperature plays a major role, exceeding other factors, such as the air-fuel ratio. The analytical conclusions are illustrated by numerical simulations after which the feasibility for actuation will be discussed. Final goal is to ensure a stable combustion in each cycle without crossing unstable combustion conditions.
<i>Sudarshan Kriya</i> Yogic Breathing in the Treatment of Stress, Anxiety, and Depression: Part II—Clinical Applications and Guidelines (2005)

Yogic breathing is a unique method for balancing the autonomic nervous system and influencing psychologic and stress-related disorders. Part I of this series presented a neurophysiologic theory of the effects of Sudarshan Kriya Yoga (SKY). Part II will review clinical studies, our own clinical observations, and guidelines for the safe and effective use of yoga breath techniques in a wide range of clinical conditions. Although more clinical studies are needed to document the benefits of programs that combine pranayama (yogic breathing) asanas (yoga postures), and meditation, there is sufficient evidence to consider Sudarshan Kriya Yoga to be a beneficial, low-risk, low-cost adjunct to the treatment of stress, anxiety, post-traumatic stress disorder (PTSD), depression, stress-related medical illnesses, substance abuse, and rehabilitation of criminal offenders. SKY has been used as a public health intervention to alleviate PTSD in survivors of mass disasters. Yoga techniques enhance well-being, mood, attention, mental focus, and stress tolerance. Proper training by a skilled teacher and a 30-minute practice every day will maximize the benefits. Health care providers play a crucial role in encouraging patients to maintain their yoga practices.
Growth and endoglucanase activity of Acetivibrio cellulolyticus grown in three different cellulosic substrates (1999)

The growth kinetics of Acetivibrio cellulolyticus grown in medium containing different carbon sources (cellobiose, amorphous or crystalline cellulose) was investigated. The specific growth rate was higher in cellobiose fed cultures than in the presence of the other two substrates. Endoglucanase production was greater in cultures grown on amorphous cellulose; enzyme activity increased during the stationary phase in cultures grown on crystalline cellulose.
Implementation of MPEG-2 transport stream remultiplexer for DTV broadcasting (2002)

This paper presents the design and implementation of an MPEG-2 transport stream (TS) remultiplexer, which is one of the most important pieces of equipment in a digital television broadcasting system. To achieve high performance as well as save hardware resources, the architecture of CAM+RAM is proposed to substitute simple RAM where a PID information table is generated. Compared to other methods, the two-step PCR correction approach can simplify the system significantly. Three data insertion modes are discussed in this paper. Among of them, the host-downloading architecture supports the system to work in a standalone mode when the contents of data are repeated with a fixed time interval or change not very fast.
Two-dimensional electron gas at differentially doped GaAs–Al<i>x</i>Ga1−<i>x</i>As heterojunction interface (1979)

We report the first observation of a two-dimensional electron gas bound to a differentially doped semiconductor heterojunction interface. Low temperature Hall mobilities up to 25 000 cm2 V−1 s−1 are observed. Angular-dependent oscillatory magnetoresistance data demonstrate the two dimensionality of the electronic system and the population of two electronic sub-bands. Cyclotron data establish the carrier mass to be 12% bigger than the conduction band edge mass of GaAs and a scattering time that is in good agreement with the scattering time obtained from the Hall mobility.
A benchmark parallel sort for shared memory multiprocessors (1988)

The first parallel sort algorithm for shared memory MIMD (multiple-instruction-multiple-data-stream) multiprocessors that has a theoretical and measured speedup near linear is exhibited. It is based on a novel asynchronous parallel merge that evenly partitions data to be merged among any number of processors. A benchmark sorting algorithm is proposed that uses this merge to remove the linear time bottleneck inherent in previous multiprocessors sorts. This sort, when applied to data set on p processors, has a time complexity of O((n log n)/p)+O((n log p)/p) and a space complexity of 2n, where n is the number of keys being sorted. Evaluations of the merge and benchmark sort algorithms on a 12-processor Sequent Balance 21000 System demonstrate near-linear speedup when compared to sequential Quicksort.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Application of Support Vector Machines to the Prediction of KOSPI (2003)

Stock market prediction is regarded as a challenging task of financial time-series prediction. There have been many studies using artificial neural networks in this area. Recently, support vector machines (DVMs) are regarded as promising methods for the prediction of financial time-series because they use a risk function consisting of the empirical error and a regularized term which is derived from the structural risk minimization principle. In this study, I apply SVM to predicting the Korea Composite Stock Price Index(KOSPI). In addition, this study examines the feasibility of applying SVM in financial forecasting by comparing it with back=propagation neural networks and case-based reasoning. The experimental results show that SVM provides a promising alternative to stock market prediction.
Reagentless Protein Assembly Triggered by Localized Electrical Signals (2008)

Electrode-imposed signals are used to assemble proteins without the need for reactive reagents. The two-step assembly approach uses i) cathodic signals to electrodeposit the amino-polysaccharide chitosan and ii) anodic signals to activate the chitosan film for protein assembly. Proteins are shown to assemble at individual electrode addresses, with spatial selectivity and quantitative control. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The Neuroprotective Effect of the Glycine Site Antagonist 3<i>R</i>-(+)-<i>cis</i>-4-Methyl-HA966 (L-687,414) in a Rat Model of Focal Ischaemia (1995)

3R-(+)-cis-4-Methyl-HA966 (L-687,414) is a novel and selective, low intrinsic activity, partial agonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor. Thus, while it acts primarily to block NMDA receptor function in the presence of glycine, it fails to produce a complete block of NMDA receptor activation. In this study, we have investigated its neuroprotective effects in a rat model of focal ischaemia, involving permanent occlusion of the left middle cerebral artery. L-687,414 was administered as a bolus dose of 17.6 mg/kg i.v. straight after the occlusion or as a bolus dose + infusion for 4 h. The doses of L-687,414 used for the infusion studies were 7 mg/kg i.v. + 7 mg/kg/h, 14 mg/kg + 14 mg/kg/h, or 30 mg/kg + 30 mg/kg/h. The 17.6-mg/kg dose gave an estimated peak plasma level of 24 micrograms/ml, which decayed with a t1/2 of 56 min. The three infusion dosing regimens gave mean plasma levels over the 4 h of 11, 25 and 61 micrograms/ml plasma, respectively. The 17.6-mg/kg dose of L-687,414 gave no significant protection against the volume of hemispheric, cortical, or caudate damage when compared with the control group of animals. The lowest infusion dosing regimen of L-687,414 which gave a plasma level of 11 micrograms/ml over the 4 h was also ineffective against the volume of infarction measured in the different brain regions.(ABSTRACT TRUNCATED AT 250 WORDS)
The Diabetes Type 1 Locus<i>Idd6</i>Modulates Activity of CD4+CD25+ Regulatory T-Cells (2006)

The genetic locus Idd6 confers susceptibility to the spontaneous development of type 1 diabetes in the NOD mouse. Our studies on disease resistance of the congenic mouse strain NOD.C3H 6.VIII showed that Idd6 influences T-cell activities in the peripheral immune system and suggest that a major mechanism by which the Idd6 locus modifies diabetes development is via modulation of regulatory T-cell activities. Our transfer experiments using total splenocytes and purified T-cells demonstrated that the locus specifically controls the efficiency of disease protection mediated by the regulatory CD4(+)CD25(+) T-cell subset. Our data also implicate the Idd6 locus in controlling the balance between infiltrating lymphocytes and antigen-presenting cells within the pancreatic islet.
Zero power 4.95Gbps HDMI transmitter (2014)

The HDMI open drain transmitter is designed to harvest power from the receiver, through the termination impedances during signaling. There is no local power supply needed at the transmitter side, neither any power is taken from the receiver apart from whatever power comes out of it during standard signaling. The zero power HDMI Transmitter capable of datarate 4.95Gbps, i.e. 1.65Gbps per Channel is designed in 65nm technology.
On distributed amplification (1955)

The response characteristics of a distributed amplifier are discussed. It is shown that they may be improved by making the delay characteristics of the anode line and the grid line different. This method, which may be called “staggering,” may be applied with advantage to almost all the conventional circuits employed in constructing distributed amplifiers. It enables one to obtain a flatter gain/frequency characteristic and a more linear phase-shift/frequency characteristic than could be obtained with the corresponding unstaggered amplifier. Photographic records of the response of experimental amplifiers to a step-voltage input show this improvement very clearly.
Lux vs. wavelength in light treatment of Seasonal Affective Disorder (2009)

Short-wavelength LED light sources may be effective in SAD treatment at fewer lux than traditional fluorescent sources.
Chemistry of Isocyanic Acid. I. Reactions of Isocyanic Acid with Carbonyl Compounds (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of Isocyanic Acid. I. Reactions of Isocyanic Acid with Carbonyl CompoundsF. W. Hoover, H. B. Stevenson, and H. S. RothrockCite this: J. Org. Chem. 1963, 28, 7, 1825–1830Publication Date (Print):July 1, 1963Publication History Published online1 May 2002Published inissue 1 July 1963https://pubs.acs.org/doi/10.1021/jo01042a020https://doi.org/10.1021/jo01042a020research-articleACS PublicationsRequest reuse permissionsArticle Views501Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Catalyst-Free Functionalization for Versatile Modification of Nonoxidized Silicon Structures (2011)

Here, we report on a simple, catalyst-free route for obtaining highly versatile subsequent functionalization on Si nanowires and Si(111) substrates. The versatility of this approach allows subsequent functionalization not only for organic species but also for inorganic (nanomaterial) species. The method has the advantage of controlling the density of reactive cross-linkers without affecting the stability of the Si samples and without having metallic (or catalyst) residues on the surface. This method also allows formation of monolayers with a variety of termination groups and is expected to open up a wide range of opportunities for producing stable molecule-based (opto)electronic and (bio)sensing devices. Immobilization of inorganic nanomaterial on the Si samples offers advanced opportunities in molecular switches, (bio)sensors, molecular scale memory, and Si-based nanoelectronic devices.
Effective identification of source code authors using byte-level information (2006)

Source code author identification deals with the task of identifying the most likely author of a computer program, given a set of predefined author candidates. This is usually .based on the analysis of other program samples of undisputed authorship by the same programmer. There are several cases where the application of such a method could be of a major benefit, such as authorship disputes, proof of authorship in court, tracing the source of code left in the system after a cyber attack, etc. We present a new approach, called the SCAP (Source Code Author Profiles) approach, based on byte-level n-gram profiles in order to represent a source code author's style. Experiments on data sets of different programming-language (Java or C++) and varying difficulty (6 to 30 candidate authors) demonstrate the effectiveness of the proposed approach.A comparison with a previous source code authorship identification study based on more complicated information shows that the SCAP approach is language independent and that n-gram author profiles are better able to capture the idiosyncrasies of the source code authors. Moreover, the SCAP approach is able to deal surprisingly well with cases where only a limited amount of very short programs per programmer is available for training. It is also demonstrated that the effectiveness of the proposed model is not affected by the absence of comments in the source code, a condition usually met in cyber-crime cases.
The fate of certain organic acids and amides in the rabbit (1948)

Investigations of the metabolism of the amino- benzoic acids in mammals have suggested that the principal methods by which these compounds are conjugated in vivo are acetylation of the amino group and conjugation of the carboxyl group with glucuronic acid. For example, Muenzen, Cerecedo & Sherwin (1926) found that m-and p-aminobenzoic acids, but not anthranilic acid, were acetylated by man and the rabbit, although none of the acids was conjugated in this way by the dog. Acetylation of p-aminobenzoic acid has also been observed in the rabbit by Ellinger & Hensel (1914), Hensel (1914), and Harrow, Mazur & Sherwin (1933) and in man
Imagerie et holographie ultrasonores (1976)

Cet article est une revue des nombreuses tentatives effectuées au cours des dix dernières années pour adapter au rayonnement acoustique les procédés développés en optique de Fourier et notamment l'holographie. Bien que la théorie mise en oeuvre soit identique pour les deux types de rayonnements, les solutions expérimentales retenues sont très différentes du fait de l'absence de film phonosensible et de l'existence de récepteurs ultrasonores linéaires. Outre les montages classiques d'imagerie et d'holographie ultrasonore, des dispositifs de conversion d'onde acousto-optiques ont pu être développés. Plus récemment, l'intérêt manifeste de l'échographie ultrasonore dans le domaine médical a suscité le développement de techniques d'exploration rapide par le balayage et la focalisation simulés électroniquement d'un transducteur à grande ouverture.
Realization of a printed-on-display antenna for mobile terminals (2002)

To develop an innovatory type of radiator, this paper presents a design method for a printed-on-display (POD) antenna, which is intended to replace the traditional ones, for example, monopole antennas, helical antennas, etc., installed on diverse wireless mobile terminals. These terminals may function as a GSM wireless telephone handset or a GPS (Global Positioning System) handset, etc. The key feature is that they have both an antenna and an electronic display. Further, for those terminals, such a new antenna design removes the drawback of being easily damaged mechanically, and is more integrated electronically. The POD antenna is composed of printed radiators which are made of a material being both electrically conductive and optically transparent, for example, ITO (indium oxide doped with tin oxide). The printed strip will be the fundamental elements for this application.
Mechanical properties and permeability of polypropylene and poly(ethylene terephthalate) mixtures (1987)

Abstract The synthetic membranes currently used for soil stabilization and road construction are mainly made of polypropylene and of polyesters. They are used separately for each application. The polymer used has an effect on the wettability and, the permeability of the membrane. The polypropylene membranes, for instance, have a zero wettability, whereas it is high for polyester membranes. This paper reports on the mechanical properties and the permeability of mixtures of polypropylene (PP) and poly(ethylene terephthalate) (PET). The elastic modulus of the mixture was at a minimum for a 50/50 mixture. For the other compositions, the moduli gave a positive deviation as compared with the additivity equation results. This is probably due to the fact that pure PET has a fragile behavior at the temperature at which the mechanical tests were run. This 50/50 composition corresponds to the domain where a phase inversion occurs. The permeability to water vapor gave an S‐shape curve that is typical of a “mixture” of immiscible polymers. The diffusion of the water molecules is controlled by the continuous phase. To compatibilize the two homopolymers, a 94/6 copolymer of PP and of polyacrylic acid was added, at various levels, to a 60/40 mixture of PET and PP: This did not affect markedly the elastic modulus. The yield stress increased, however, indicating that we had a better adhesion and that the copolymer seems to have a certain emulsifier effect, increasing the quality of the dispersion.
Improving Sample Distribution Homogeneity in Three-Dimensional Microfluidic Paper-Based Analytical Devices by Rational Device Design (2017)

Paper-based devices are a portable, user-friendly, and affordable technology that is one of the best analytical tools for inexpensive diagnostic devices. Three-dimensional microfluidic paper-based analytical devices (3D-μPADs) are an evolution of single layer devices and they permit effective sample dispersion, individual layer treatment, and multiplex analytical assays. Here, we present the rational design of a wax-printed 3D-μPAD that enables more homogeneous permeation of fluids along the cellulose matrix than other existing designs in the literature. Moreover, we show the importance of the rational design of channels on these devices using glucose oxidase, peroxidase, and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) reactions. We present an alternative method for layer stacking using a magnetic apparatus, which facilitates fluidic dispersion and improves the reproducibility of tests performed on 3D-μPADs. We also provide the optimized designs for printing, facilitating further studies using 3D-μPADs.
LOPERAMIDE, AN OPIATE ANALOGUE, INHIBITS PLASMA ACTH LEVELS IN PATIENTS WITH ADDISON'S DISEASE (1986)

The effects of loperamide, an opiate analogue of the piperidine class on pituitary hormone secretion were evaluated in eight patients with Addison's disease. In all patients loperamide administration (16 mg orally) induced a marked fall in plasma ACTH levels (P less than 0.01), without affecting GH, PRL and LH levels. Plasma ACTH concentration fell significantly from 854 +/- 167 pg/ml (mean +/- SEM) to 460 +/- 123 pg/ml at 60 min (P less than 0.01). The inhibition persisted throughout the whole test period, the nadir being reached at 300 min. Low dose naloxone infusion 180 min after loperamide administration caused plasma ACTH to rise from 181 +/- 61 pg/ml to 539 +/- 99 pg/ml (P less than 0.01). The present data suggest that the opiate analogue loperamide is a potent inhibitor of ACTH secretion in patients with Addison's disease, which may be acting on mu receptors, since its effect is blocked by low doses of naloxone.
Determination of Far Field Stress from the Point Stress Measurement, a Numerical Approach. (1998)

The combination between numerical methods and field measurements have been used by many researchers to analyze rock engineering problems. In numerical analyses, the far field stress state should be postulated at the beginning. As the results, however, it happens that generally the calculated stress does not match correctly with the measured stress. The fault can be addressed to the postulated far field stress state, since the high confidence of in-situ measurement technique has been used. In order to eliminate this difference, a kind of back analysis has been developed by the authors to determine the far field stress state using 3D FSM (3 Dimensional Fictitious Stress Method). The model of topography and the real field case were used to confirm the applicability of the calculation procedure. From this study, it is shown that the method is convenient to determine correctly the far field stress state, if the topography perturbation of the stress state at an arbitrary point A can be modelized using FSM, and if each component of the far field stress state is defined as a linear function of depth.