gebhart/patrepeval huggingface dataset:
Characteristics of gluten-free bread: quality improvement by the addition of starches/hydrocolloids and their combinations using a definitive screening design (2017)

To establish factors affecting the quality of gluten-free bread based on rice semolina supplemented with field bean semolina and improving its final quality, a new study with definitive screening design was conducted after an appropriate choice of six factors: agar–agar, water, two types of gums gum arabic and locust bean gum, and two types of starches tapioca starch and corn starch. We investigated the effect of the aforementioned parameters on specific volume, hardness, chewiness, and springiness of breads. The results showed that specific volume of gluten-free breads increased significantly (p < 0.05) with the addition of gum arabic, tapioca and corn starches, and water; addition of agar–agar, gum arabic, tapioca starch and water affected the hardness. With regard to chewiness, the results showed that gum arabic and water and also the interaction between them had a significant effect. Gum arabic, tapioca and corn starches, and water affected the springiness. In addition, we observed the interactions among the additives. For all the tested parameters, water and gum arabic had statistically significant (p < 0.0001) effect and affected all the properties of examined breads. These factors were retained for process characterization of optimized gluten-free bread. The final optimum formulation of rice/field bean contained 1.5% of gum arabic and 71.5% of water. The optimum gluten-free bread with gum arabic showed high volume, good textural, structural, and sensory qualities with high acceptability compared to the gluten-free control bread without any improver.
A simple, mild and environmentally benign procedure for the cleavage of carbon–nitrogen double bonds using NaBrO<sub>3</sub>in the presence of [bmim]HSO<sub>4</sub> (2014)

A clean, mild and efficient deprotection of oximes, hydrazones, phenyl hydrazones, tosylhydrazones, Schiff's bases and azines to their corresponding carbonyl compounds has been developed using sodium bromate in the presence of acidic ionic liquid [bmim]HSO4 at 60 °C. The experimental procedure is simple and the products are isolated in high yields. The ionic liquid [bmim]HSO4 could be easily recovered and recycled.
<i>Staphylococcus aureus</i> Adhesion via Spa, ClfA, and SdrCDE to Immobilized Platelets Demonstrates Shear-Dependent Behavior (2006)

Addition of plasma proteins potentiates S aureus-platelet interactions at all shear rates examined. Whereas fibrinogen plays a significant role in all shear regimes, VWF mediation becomes increasingly important as wall shear rate increases. Fibrinogen binding is dependent on bacterial adhesins ClfA and SdrCDE whereas Spa is the dominant receptor for VWF.
A versatile and practical method for regioselective synthesis of polysubstituted furanonaphthoquinones (2012)

An efficient and attractive synthesis of a series of novel poly-functionalized phosphorus zwitterions was achieved via three-component reactions of the corresponding functional nucleophiles, aldehydes, and Bu(3)P in the presence of acidic promoter. These polysubstituted zwitterions could regioselectively undergo further transformations to synthetically important furanonaphthoquinones and related products via the intramolecular Wittig reaction. These methods could have potential application in synthetic and pharmaceutical chemistry for its facilitation and easily accessible commercial materials.
Enhanced Interfacial Adhesion and Osteogenesis for Rapid “Bone-like” Biomineralization by PECVD-Based Silicon Oxynitride Overlays (2015)

Structurally unstable fracture sites require metal fixative devices, which have long healing times due to their lack of osteoinductivity. Bioactive glass coatings lack in interfacial bonding, delaminate, and have reduced bioactivity due to the high temperatures used for their fabrication. Here, we test the hypothesis that low-temperature PECVD amorphous silica can enhance adhesion to the underlying metal surface and that N incorporation enhances osteogenesis and rapid biomineralization. A model Ti/TiO2-SiOx interface was formed by first depositing Ti onto Si wafers, followed by surface patterning, thermal annealing to form TiO2, and depositing SiOx/Si(ON)x overlays. TEM micrographs showed conformal SiOx layers on Ti/TiO2 overlays while XPS data revealed the formation of an elemental Ti-O-Si interface. Nanoscratch testing verified strong SiOx bonding with the underlying TiO2 layers. In vitro studies showed that the surface properties changed significantly to reveal the formation of hydroxycarbonate apatite within 6 h, and Si(ON)x surface chemistry induced osteogenic gene expression of human periosteal cells and led to a rapid "bone-like" biomineral formation within 4 weeks. XANES data revealed that the incorporation of N increased the surface HA bioactivity by increasing the carbonate to phosphate ratio. In conclusion, silicon oxynitride overlays on bone-implant systems enhance osteogenesis and biomineralization via surface nitrogen incorporation.
Structural health monitoring of offshore wind turbines using automated operational modal analysis (2014)

This article will present and discuss the approach and the first results of a long-term dynamic monitoring campaign on an offshore wind turbine in the Belgian North Sea. It focuses on the vibration levels and modal parameters of the fundamental modes of the support structure. These parameters are crucial to minimize the operation and maintenance costs and to extend the lifetime of offshore wind turbine structure and mechanical systems. In order to perform a proper continuous monitoring during operation, a fast and reliable solution, applicable on an industrial scale, has been developed. It will be shown that the use of appropriate vibration measurement equipment together with state-of-the art operational modal analysis techniques can provide accurate estimates of natural frequencies, damping ratios, and mode shapes of offshore wind turbines. The identification methods have been automated and their reliability has been improved, so that the system can track small changes in the dynamic behavior of offshore wind turbines. The advanced modal analysis tools used in this application include the poly-reference least squares complex frequency-domain estimator, commercially known as PolyMAX, and the covariance-driven stochastic subspace identification method. The implemented processing strategy will be demonstrated on data continuously collected during 2 weeks, while the wind turbine was idling or parked.
Adjuvant effects of diethylaminoethyl-dextran (1976)

Diethylaminoethyl-dextran exhibited a significant effect on the primary immune response of rhesus monkeys to formalin-inactivated Venezuelan equine encephalomyelitis virus vaccine (IVEE). Antibody formed to IVEE and adjuvant followed a classic immunoglobulin M-immunoglobulin G pattern; however, as compared with vaccine alone, use of this adjuvant with IVEE reduced the time required for onset of immunoglobulin G synthesis.
A 1.8-GHz injection-locked quadrature CMOS VCO with low phase noise and high phase accuracy (2006)

Injection-locked quadrature voltage-controlled oscillators are introduced in this paper as high accuracy, low phase noise, and low-power I and Q generators. A master voltage-controlled oscillator (VCO), running at twice the output frequency, locks two coupled VCOs. The former determines phase noise while the latter sets phase accuracy, thus, breaking the tradeoff between the two parameters, the main limit of free running coupled VCOs, recently proposed in the framework of highly integrated solutions. The proposed design has been tailored to DCS 1800 and prototypes have been fabricated in a 0.18-mum CMOS technology. Experiments show a phase noise of -127 dBc/Hz and -139 dBc/Hz at 600 kHz and 3 MHz, respectively, while consuming 10 mA from 1.8 V supply. A 185-dB state-of-the-art phase noise figure of merit results. Accuracy between output signals is determined by means of image band rejection (IBR) measurements on a purposely developed single-side-band upconversion mixer. Minimum IBR among 20 samples is as large as 46 dB
Vision for Looking at Traffic Lights: Issues, Survey, and Perspectives (2016)

This paper presents the challenges that researchers must overcome in traffic light recognition (TLR) research and provides an overview of ongoing work. The aim is to elucidate which areas have been thoroughly researched and which have not, thereby uncovering opportunities for further improvement. An overview of the applied methods and noteworthy contributions from a wide range of recent papers is presented, along with the corresponding evaluation results. The evaluation of TLR systems is studied and discussed in depth, and we propose a common evaluation procedure, which will strengthen evaluation and ease comparison. To provide a shared basis for comparing TLR systems, we publish an extensive public data set based on footage from U.S. roads. The data set contains annotated video sequences, captured under varying light and weather conditions using a stereo camera. The data set, with its variety, size, and continuous sequences, should challenge current and future TLR systems.
Forward‐looking intravascular orthogonal‐solenoid coil for imaging and guidance in occlusive arterial disease (2008)

Recent intravascular imaging coil configurations have focused on side-viewing catheters capable of imaging the vessel wall of a patent vessel. These designs suffer from the presence of signal nulls and the inability to image in front of a device when it is oriented along the main static field. This is of particular importance when a device is being navigated through an occlusive lesion. To address these limitations we propose a new intravascular coil design consisting of two independent orthogonal solenoids located at the catheter tip. The two coils are oriented in such a way that signal nulls are eliminated and imaging is possible in planes located directly in front of the catheter. Complete characterization of the spatial signal-to-noise ratio (SNR) distribution of the design is presented. The coil configuration was fabricated on a 6F guide catheter, and its use is demonstrated in phantoms and in vivo.
Implementing Reduced-Risk Integrated Pest Management in Fresh-Market Cabbage: Improved Net Returns via Scouting and Timing of Effective Control (2008)

During 1998–2001, field studies were done to assess the efficacy of an integrated pest management (IPM) program using an action threshold and “reduced-risk” insecticides. The IPM program was compared with a conventional grower-based program. Program performance was evaluated based on management of Trichoplusia ni (Hübner), Pieris (=Artogeia) rapae (L.), and Plutella xylostella (L.), as well as the economic impact of each program on net returns. The action threshold used in the IPM program consisted of 10% plants infested with T. ni larvae, based on previous small-plot experiment station trials. In all years of the study, the IPM program resulted in significantly lower percentages of plants infested than the conventional program or untreated check. The mean reduction in insecticide applications for the IPM program compared with the conventional program was 23.5%, whereas, on average, the costs of the IPM program were 46.0% higher than the conventional program. Pest reduction in the IPM program resulted in an average of 10.5% higher marketable yields than the conventional program. Percentages of marketable heads in the IPM program ranged from 82 to 99% and from 63 to 96% in the conventional program. Mean net returns for the IPM program exceeded the conventional program by $984.20/ha. These results indicated that the IPM program reduced insecticide use overall, even though costs of the IPM program, with either spinosad or indoxacarb, were sometimes higher. Overall, net returns of the IPM program were higher due to active pest scouting, improved application timing, and increases in marketable yield. Given the potential decrease in insecticide applications and increases in net profit resulting from this IPM program, additional analyses should be conducted to quantify the economic risk, or consistency of the results, to fully evaluate the benefits of the IPM program compared with a conventional program.
Do Nonsteroidal Anti-inflammatory Drugs Affect Blood Pressure? A Meta-Analysis (1994)

Nonsteroidal anti-inflammatory drugs may elevate blood pressure and antagonize the blood pressure-lowering effect of antihypertensive medication to an extent that may potentially increase hypertension-related morbidity. Although certain NSAIDs and antihypertensive agents could be more likely to produce these effects, the underlying mechanisms require further study.
Dispersion Analysis of a Microstrip Line at Higher Frequencies by Using Sonnet and Matlab (2011)

This paper we mainly emphasize on simulation & synthesis of micro strip line by using powerful simulation tools like sonnet and matlab. Many researchers have investigated the dispersion characteristics of micro strip lines at different higher frequency range. This paper we analyzed the micro strip line with characteristic impedance 50Ω at frequency range 1 to 20GHz for Alumina, Gallium Arsenide and Silicon substrate materials. All parameters of the micro strip lines are exactly determined from the empirical formula of micro strip line. Here we compare the results of the dispersion formulas on the software tools.
39.1: Adaptive Dimming and Boosting Backlight for LCD‐TV Systems (2007)

Abstract The limited transmittance of LCD panels can be observed as a waste of energy, leading to a limited brightness. Light leaking through LCD panels driven to black, can be observed as a poor black‐level, limiting the contrast ratio. Adaptive Dimming Backlight technology can be applied to attenuate the backlight luminance, improving local contrast, black‐level and saving power. The optical crosstalk between the controllable backlight segments has a negative impact on the dimming performance, limiting the spatial backlight luminance modulation. Crosstalk Compensation can partly compensate this artifact, enhancing the spatial modulation of the segments. Adaptive Boosting Backlight technology can be applied to boost the output of the panel over 100%. This improves the local brightness and contrast for a sparkling picture, still saving power. Crosstalk compensation enables deeper dimming. Deeper dimming improves on contrast and enables more boosting for an even brighter picture. So when these technologies are combined: The contrast may increase up to 5 times (CCFL/EEFL). The brightness may double and contrast may increase up to 20 times (HCFL). Alternatively, for 2D‐Dimming the spatial contrast may increase up to a factor of 100 and the temporal contrast may increase to infinite (LED). At the same time, up to 50% average power can be saved!
[Active forms of oxygen and pathogenesis of rheumatoid arthritis and systemic lupus erythematosus]. (1996)

In this paper the authors underline the significance of studies into the body's free radical oxidation, analyze the involvement of free radical reactions in the maintenance of homeostasis. They indicate that free radical metabolic changes leading to oxidative stress play a role in the pathogenesis of many human diseases. Particular emphasis is laid on the contribution of active forms of oxygen (AFO) in the development of autoimmune diseases, including rheumatic diseases. The history of this problem is outlined. There are examples that confirm the enhancement of free radical processes and the inhibition of the antioxidative system in rheumatic arthritis (RA) and some other rheumatic diseases. The essential drugs used in the treatment of RA patients are demonstrated to also act due to the inhibited "respiratory outbreak" of phagocytes. The key point of the paper is the role of free radical reactions in the pathogenesis of systemic lupus erythematosus (SLE). There is evidence suggesting that there is a reduction in antioxidative defense and a rise in neutrophilic production of AFO in SLE patients. Consideration is also given to the possible participation of AFO in the formation of DNA antibodies, the effects of AFO on the immune system, atherogenesis in SLE. Taking into account a possible contribution of AFO in the pathogenesis of SLE, it is expedient to include antiradical agents into the multimodality therapy for this disease and promising to continue investigations in this field.
Diagnostic and Statistical Manual for Primary Care (DSM-PC) Child and Adolescent Version: Design, Intent, and Hopes for the Future (1997)

Journal of Developmental & Behavioral Pediatrics: June 1997 - Volume 18 - Issue 3 - p 171-172
Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast (2016)

Cellular phenotypes are the result of complex interactions between many components. Understanding and predicting the system level properties of the resulting networks requires the development of perturbation tools that can simultaneously and independently modulate multiple cellular variables. Here, we develop synthetic modules that use different arrangements of two transcriptional regulators to achieve either concurrent and independent control of the expression of two genes, or decoupled control of the mean and variance of a single gene. These modules constitute powerful tools to probe the quantitative attributes of network wiring and function.
Maternal chromatin remodeling during maturation and after fertilization in mouse oocytes (2004)

Immunofluorescence staining with antibodies against acetylated histone H4 and 5-methylcytosine was carried out to investigate female chromatin remodeling throughout oocyte maturation and chromatin rearrangement involving both male and female genomes after fertilization. Oocyte cytoplasm remodels female chromatin in preparation of the fertilizing event and the subsequent chromatin rearrangement. Histone H4 are in fact progressively deacetylated whereas demethylating enzymes do not seem to be active over this period. The acetylase/deacetylase balance seems to be cell cycle dependent as female chromatin is deacetylated during maturation and reacetylated at telophase II stage both after fertilization and activation. On the contrary, DNA demethylation seems to be strictly selective. It is in fact confined to the remodeling of paternal genome after fertilization of mature oocytes as the ooplasm is not effective in demethylating either paternal chromatin in germinal vesicle breakdown (GVBD) fertilized oocytes or maternal genome of partenogenetically activated oocytes. Surprisingly, we induced maternal chromatin demethylation after fertilization by treating oocytes with a combination of a methyltransferase inhibitor, 5-azacytidine (5-AzaC), and a reversible and specific inhibitor of histone deacetylase, trichostatin A (TSA). This treatment likely induces a hyperacetylation of histones (thus favoring the access to demethylating enzymes by opening female chromatin structure) associated with a block of reparative methylation by inhibiting methytransferases. This manipulation of chromatin remodeling may have applications regarding the biological significance of aberrant DNA methylation.
Ion Channel Genes in the Heart (1996)

Over the past 30 years, approximately a dozen membrane currents have been identified that contribute to the cardiac action potential. Over the past 5 years, an even larger number of genes have been isolated that are responsible for these currents. Thus, the number of genes exceeds the number of currents. This disproportion will undoubtedly change because the gene products may be assembled into a vast number of different combinations, thereby yielding many new currents. A new era has clearly begun: the era of molecular cardiac electrophysiology in which the elaborate control of the single most important electrical event of life, the cardiac action potential, will be delineated.
Targeting XIAP Bypasses Bcl-2–Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth <i>In vitro</i> and <i>In vivo</i> (2008)

Resistance to apoptosis is a hallmark of pancreatic cancer, a leading cause of cancer deaths. Therefore, novel strategies are required to target apoptosis resistance. Here, we report that the combination of X-linked inhibitor of apoptosis (XIAP) inhibition and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an effective approach to trigger apoptosis despite Bcl-2 overexpression and to suppress pancreatic cancer growth in vitro and in vivo. Knockdown of XIAP by RNA interference cooperates with TRAIL to induce caspase activation, loss of mitochondrial membrane potential, cytochrome c release, and apoptosis in pancreatic carcinoma cells. Loss of mitochondrial membrane potential and cytochrome c release are extensively inhibited by a broad range or caspase-3 selective caspase inhibitor and by RNAi-mediated silencing of caspase-3, indicating that XIAP inhibition enhances TRAIL-induced mitochondrial damage in a caspase-3-dependent manner. XIAP inhibition combined with TRAIL even breaks Bcl-2-imposed resistance by converting type II cells that depend on the mitochondrial contribution to the death receptor pathway to type I cells in which TRAIL-induced activation of caspase-3 and caspase-9 and apoptosis proceeds irrespective of high Bcl-2 levels. Most importantly, XIAP inhibition potentiates TRAIL-induced antitumor activity in two preclinical models of pancreatic cancer in vivo. In the chicken chorioallantoic membrane model, XIAP inhibition significantly enhances TRAIL-mediated apoptosis and suppression of tumor growth. In a tumor regression model in xenograft-bearing mice, XIAP inhibition acts in concert with TRAIL to cause even regression of established pancreatic carcinoma. Thus, this combination of XIAP inhibition plus TRAIL is a promising strategy to overcome apoptosis resistance of pancreatic cancer that warrants further investigation.
Effects of organoclays on morphology and thermal and rheological properties of polystyrene and poly(methyl methacrylate) blends (2002)

Abstract Morphology, thermal and rheological properties of polymer‐organoclay composites prepared by melt‐blending of polystyrene (PS), poly(methyl methacrylate) (PMMA), and PS/PMMA blends with Cloisite® organoclays were examined by transmission electron microscopy, small‐angle X‐ray scattering, secondary ion mass spectroscopy, differential scanning calorimetry, and rheological techniques. Organoclay particles were finely dispersed and predominantly delaminated in PMMA‐clay composites, whereas organoclays formed micrometer‐sized aggregates in PS‐clay composites. In PS/PMMA blends, the majority of clay particles was concentrated in the PMMA phase and in the interfacial region between PS and PMMA. Although incompatible PS/PMMA blends remained phase‐separated after being melt‐blended with organoclays, the addition of organoclays resulted in a drastic reduction in the average microdomain sizes (from 1–1.5 μm to ca. 300–500 nm), indicating that organoclays partially compatibilized the immiscible PS/PMMA blends. The effect of surfactant (di‐methyl di‐octadecyl‐ammonia chloride), used in the preparation of organoclays, on the PS/PMMA miscibility was also investigated. The free surfactant was more compatible with PMMA than with PS; the surfactant was concentrated in PMMA and in the interfacial region of the blends. The microdomain size reduction resulting from the addition of organoclays was definitely more significant than that caused by adding the same amount of free surfactant without clay. The effect of organoclays on the rheological properties was insignificant in all tested systems, suggesting weak interactions between the clay particles and the polymer matrix. In the PS system, PMMA, and organoclay the extent of clay exfoliation and the resultant properties are controlled by the compatibility between the polymer matrix and the surfactant rather than by interactions between the polymer and the clay surface. © 2002 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 41: 44–54, 2003