gebhart/patrepeval huggingface dataset:
In vitro antitumor lymphocyte generation using dendritic cells and innate immunity mechanisms as tumor cell treatments. (2007)

Dendritic cells play a central role in the initiation and regulation of acquired and innate immunity, playing an important role in immunosurveillance and antitumor reaction. This reaction is mediated by effector cells and soluble factors. We chose to investigate four dendritic cell loading methods by mimicking innate immunity mechanisms and using whole tumor cell treatments in order to stimulate lymphocytes: sodium hypochlorite, TNFalpha and IFNgamma and IgG opsonization. These methods were compared in an HLA.A2 model of healthy donors and with the M74 melanoma cell line. Treated tumor cell-loaded DC were able to increase proliferation of lymphocytes. Moreover, a CTL population was stimulated, as shown by their specific cytotoxicity against tumor cells (with w6/32 antibody assays), against MelanA/MART-1 loaded T2 cells and using MelanA/MART-1 tetramer. IgG opsonization seemed to be less efficient than other tumor cell treatments. These loaded DC, or the obtained effector cells, could be interesting for therapeutic applications in antitumor cell therapy.
Effects of methylmercury on prenatal development in mice (1972)

Abstract Single doses (2, 4, or 8 mg/kg) of methylmercury dicyandiamide (MMD) were given ip to 129/SvS1 and A/J pregnant mice on days 6‐13 of gestation and fetuses were examined on day 15 or 18. Results indicated that MMD (1) retarded growth in both strains; (2) retarded stage of development in 129s; (3) was embryolethal and teratogenic (brain, palate, or facial defects) in 129s when administered on days 9‐13 but not on days 6‐8; (4) was not embryolethal in As; and (5) was teratogenic (palate and jaw defects) in As when injected on days 9‐13. All of the quantities measured were found to vary with day of treatment, dose, and strain.
Resistive Switching in High-Density Nanodevices Fabricated by Block Copolymer Self-Assembly (2015)

Bipolar resistive switching memories based on metal oxides offer a great potential in terms of simple process integration, memory performance, and scalability. In view of ultrahigh density memory applications, a reduced device size is not the only requirement, as the distance between different devices is a key parameter. By exploiting a bottom-up fabrication approach based on block copolymer self-assembling, we obtained the parallel production of bilayer Pt/Ti top electrodes arranged in periodic arrays over the HfO2/TiN surface, building memory devices with a diameter of 28 nm and a density of 5 × 10(10) devices/cm(2). For an electrical characterization, the sharp conducting tip of an atomic force microscope was adopted for a selective addressing of the nanodevices. The presence of devices showing high conductance in the initial state was directly connected with scattered leakage current paths in the bare oxide film, while with bipolar voltage operations we obtained reversible set/reset transitions irrespective of the conductance variability in the initial state. Finally, we disclosed a scalability limit for ultrahigh density memory arrays based on continuous HfO2 thin films, in which a cross-talk between distinct nanodevices can occur during both set and reset transitions.
Active immunisation of black tiger prawn (Penaeus monodon) against vibriosis in Thailand. (1999)

Mechanisms of host defence in Crustaceae and vibriosis in shrimp and methods for its prevention are discussed as introduction. The own work deals with the development of a site-specific multivalent anti-vibrio vaccine and its application in Thailand. The vaccine was produced in a continuous bioreactor system from field strains of Vibrio alginolyticus, V. harveyi, V. parahaemolyticus and V. vulnificus, purified through ultrafiltration, and inactivated by formalin. It was applied to Penaeus monodon PL prior to release into the ponds via artemia larvae. As mean result from numerous trials carried out under commercial field conditions in Eastern Thailand it was shown that the PL tolerated the vaccine perfectly. Due to technical problems only few of the field trials could be monitored until harvest. The data available allow claiming an obvious protective effect of the vaccine.
Survey on converged data center networks with DCB and FCoE: standards and protocols (2013)

Data center networks today face exciting new challenges in supporting cloud computing and other data-intensive applications. In conventional DCNs, different types of traffic are carried by different types of networks, such as Ethernet and Fibre Channel. Typically, Ethernet carries data traffic among servers in LANs, and Fibre Channel connects servers and storages in storage area networks. Due to the existence of multiple networks, the network cost, power consumption, wiring complexity, and management overhead are often high. The concept of a converged DCN is therefore appealing, carrying both types of traffic in a single converged Ethernet. Recent standards have been proposed for unified data center bridging (DCB) Ethernet and Fibre Channel over Ethernet (FCoE) protocols by the DCB Task Group of IEEE and the T11 Technical Committee of INCITS. In this article, we give a survey of the standards and protocols on converged DCNs, focusing mainly on their motivations and key functionalities. The technologies are discussed mainly from a practical perspective and may serve as a foundation for future research in this area.
Recent Advancements in DataPlay's Small Form-Factor Optical Disc and Drive (2006)

A small form-factor 0.85NA red laser system with 1 GB capacity per 32 mm cartridge will be reviewed. Test results from write once media and newly developed first surface rewritable media will be shown. Modifications to the micro optical pickup (OPU) to use a high power laser diode to support rewritable media will be described, and results of thermal analysis of the complete drive system will be presented.
Calcium Alginate Gel as a Biocompatible Material for Endovascular Arteriovenous Malformation Embolization: Six-month Results in an Animal Model (2005)

Over a period of 6 months, calcium alginate was an effective endovascular occlusion material that blocked blood flow to the inferior portion of the RM. The chronic AVM model verified the long-term stability and biocompatibility of calcium alginate.
T cells, IgE antibodies, cytokines and allergic inflammation. (1991)

T helper cell (Th) subsets producing interleukin 4 (IL-4) or gamma interferon (IFN) play a reciprocal role in the regulation of human IgE synthesis. Though necessary, IL-4 alone was insufficient. Patients with hyper-IgE had significantly lower proportions of T-cells that produce IFN and TNF, but not IL-2 or IL-4. In patients with helminth infections or atopy production of IgE and eosinophilia may result from expansion of Th-2-like cells. T cell clones (TCC) specific for allergens and Toxocara canis (TES) showed dichotomy in cytokine secretion. Non-atopic donors gave insufficient TCC for comparison. Activation of the fibroblasts of the respiratory mucosae induces production of interstitial proteins such as collagen III, V, fibronectin.
Multinuclear Sandwich‐type Complexes of Deprotonated β‐Cyclodextrin and Copper(<scp>II</scp>) Ions (1993)

The especially attractive structure of the complex anion 1 demonstrates that sugars need not be derivatized for the construction of stable metal complexes. The two β-cyclodextrin tori (deprotonated a total of 19 times) are linked by Cu2+ ions to form the double torus shown schematically on the right; the hydrophobic interior is divided into two halves by a heptagon of lithium atoms and a heptagon of water molecules.
<i>Mycobacterium tuberculosis</i> phagosome (1999)

The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells. Among other factors, compartment-specialized regulators of vesicular trafficking and other parts of membrane fusion machinery are likely to play a role in these processes. Here we summarize the emerging view of mycobacterial phagosome maturation arrest in the context of the dynamic processes of intracellular membrane trafficking.
Preparation and optical characterization of Au/SiO2 composite films with multilayer structure (2003)

An investigation of Au/SiO2 composite multilayer films with a large third-order optical nonlinearity is reported in this article. Multilayer films containing Au nanoparticles with narrow size and shape distributions can be obtained by controlling the thickness of the Au layer, as well as the annealing temperature and time duration. It is found that the peak of surface plasmon resonance (SPR) of films with mean nanoparticle size of 30 nm is located at 2.35 eV with a width of 350 meV. The SPR peak of films containing larger or smaller particles red-shifts and broadens due to the particle size and shape effects. The third-order optical nonlinear susceptibility χ(3) of these films has a maximum value of about 5.1×10−6 esu at 532 nm when the mean nanoparticle size is around 30 nm. We attribute the observed size dependence of χ(3) to the competition between the enhancement of the local field factor and the skin-depth effect.
Color Indices for Weed Identification Under Various Soil, Residue, and Lighting Conditions (1995)

Color slide images of weeds among various soils and residues were digitized and analyzed for red, green, and blue (RGB) color content. Red, green, and blue chromatic coordinates (rgb) of plants were very different from those of background soils and residue. To distinguish living plant material from a nonplant background, several indices of chromatic coordinates were studied, tested, and were successful in identifying weeds. The indices included r-g, g-b, (g-b)/ |r-g|, and 2g-r-b. A modified hue was also used to distinguish weeds from non-plant surfaces. The modified hue, 2g-r-b index, and the green chromatic coordinate distinguished weeds from a nonplant background (0.05 level of significance) better than other indices. However, the modified hue was the most computationally intense. These indices worked well for both nonshaded and shaded sunlit conditions. These indices could be used for sensor design for detecting weeds for spot spraying control.
Impact of Cost Sharing on Therapeutic Substitution: The Story of Statins in 2006 (2016)

Increases in cost-sharing differentials for brand name and generic drugs on coverage gap entry were associated with discontinuation of statins in Medicare Part D patients with hyperlipidemia.
Selective optical detection of n-heptane/iso-octane vapors by polyimide lightguides (1995)

The optical anisotropy of planar polyimide lightguides in an atmosphere of n-heptaney/iso-octane is investigated in a transient experiment for pure and several mixed-vapor concentrations. The polymer sensor responds only to n-heptane and not to iso-octane vapors. However, the presence of the latter affects the dynamic behavior of the waveguide anisotropy, which can be fitted by a stretched exponential time dependence. The saturation values of the birefringence are an absolute measure for the n-heptane concentration and are not affected by the presence of the iso-octane vapors.
A block ACK transmission scheme for reliable multicast in IEEE 802.11 WLANs (2016)

Multicast over wireless medium is considered for multimedia service such as YouTube and NetFlix. However, the multicast frames are sent in a low data rate without the feedback in IEEE 802.11. The low data rate of multicast causes performance anomaly problem. In this paper, we propose a feedback overhead reduction scheme to guarantee the reliable multicast, and to sustain the high throughput in recent IEEE 802.11. In our proposed scheme, multicast members send acknowledgement frames when they miss data frames. Multicast data frames are retransmitted according to the acknowledgment. The attempt to shrink the overhead for the feedback allows the opportunity to transmit more data. In simulations, our proposed scheme alleviates the degradation of the network throughput according to the increase of the multicast group size.
Importance of specific adenosine N7-nitrogens for efficient cleavage by a hammerhead ribozyme. A model for magnesium binding (1992)

Five modified hammerhead ribozyme/substrate complexes have been prepared in which individual adenosine N7-nitrogens have been excised. The modified complexes were chemically synthesized with the substitution of a single 7-deazaadenosine (c7A) base analogue for residues A11, A14, A26, A27, or A28. Two of the base analogues, c7A11 and c7A14, occur in a 19-mer ribozyme, while the remaining three residues, c7A26, c7A27, and c7A28, are present in a 24-mer substrate. Under stoichiometric conditions, four of the complexes are cleaved with relatively little change in rate when compared with that of the native complex. However, the relative rate for the c7A11 complex is some 35-fold slower than that of the native complex. Steady-state kinetic analyses indicate that the cleavage efficiencies, as measured by kcat/KM, for the c7A14, c7A26, c7A27, and c7A28 complexes are reduced 18-fold, 10-fold, 34-fold, and 16-fold, respectively. These reductions in cleavage efficiency are primarily a result of lower kcat values. By comparison, the cleavage efficiency of the c7A11 complex is reduced more than 200-fold relative to that of the native complex, again primarily as a result of a lower kcat value. The results suggest that the N7-nitrogen of A11 in the hammerhead ribozyme/substrate complex is critical for efficient cleavage activity. The results of the present work, in combination with those from previous reports, indicate that five critical functional groups are located within the tetrameric sequence G10A11U12G13. A preliminary model for the binding of a single magnesium cofactor to this portion of the sequence is proposed.(ABSTRACT TRUNCATED AT 250 WORDS)
Assessing Pruritus in Hidradenitis Suppurativa: A Cross-Sectional Study (2017)

Pruritus is a frequent but underreported symptom in patients with HS. Its moderate to severe intensity and significant impact on daily activities have great potential to impair patients' quality of life.
Demonstration of a Cylinder Fill System Based on Solid Electrolyte Oxygen Separator (SEOS) Technology: Early Field Assessment at a USAF Maintenance Facility (2010)

Abstract : The goal of the effort was to conduct an early field assessment of SEOS oxygen-generation technology. A SEOS breadboard for charging high pressure oxygen cylinders was installed in a maintenance facility at Oklahoma City-Air Logistics Center (OC-ALC), Tinker AFB OK. The SEOS breadboard was capable of generating 99.9+% oxygen at pressures up to 2,200 psig using electric power. The oxygen was stored in high pressure cylinders. The oxygen was tested per MIL-PRF-27210, Aviator's Breathing Oxygen (ABO), and it passed the ABO specification. The SEOS oxygen production unit worked well to fill aircraft oxygen bottles. On 20 Nov 09 the first aircraft oxygen bottle was filled with SEOS oxygen. During the effort several electrical problems on the compressor and ancillary electrical equipment were addressed. The SEOS electrochemical stacks used to generate the high purity oxygen functioned as expected. Tinker AFB operating personnel found the system very easy to use and it reduced safety risks associated with frequent change-out of vendor-supplied oxygen bottles. The early field assessment effort will be continued under USAF Contract F41624-00-C-6000.
SAT-based semiformal verification of hardware (2010)

Semiformal, or hybrid, verification techniques are extensively used in pre-silicon hardware verification. Most approaches combine simulation and formal verification (FV) algorithms to achieve better design coverage than conventional simulation and scale better than FV. In this paper we introduce a purely SAT-based semiformal verification (SFV) method that is based on new algorithms for generating multiple heterogeneous models for a propositional formula. An additional novelty of our paper is the extension of the SFV algorithm to liveness properties. The experimental data presented in this paper clearly shows that the proposed method can effectively find bugs in complex industrial designs that neither simulation nor FV reveal.
Power sequencing approach to fault isolation in dc systems: Influence of system parameters (2010)

We show that medium-voltage dc power buses can be protected against short circuit faults by coordinating the action of a converter that supplies power to the bus with the action of contactors that are used to reconfigure the bus connections. Following a fault, the bus is de-energized (so there is no large current to interrupt), one or more contactors are reconfigured, and the dc bus is then reenergized. For a typical industrial dc bus, we show that it is possible to execute this de-energize-reconfigure-re-energize process 10 times faster than an AC bus can be protected and reconfigured using traditional circuit breakers. We show how the de-energizing and reconfiguring times depend on the output capacitance of the main converter and on the distance to the fault, and we show how to size each hold-up capacitor so that loads on unfaulted circuits can ride through the process uninterrupted.
Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth. (2002)

Copper zinc superoxide dismutase (CuZnSOD) is an essential primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular oxygen in the cytoplasm. Cytosolic glutathione peroxidase (GPx) converts hydrogen peroxide into water. The overall goal of the present study was to explore the possible role of the antioxidant enzyme CuZnSOD in expression of the malignant phenotype. We hypothesized that overexpression of CuZnSOD would lead to the suppression of at least part of the human malignant phenotype. To test this hypothesis, human CuZnSOD cDNA was transfected into U118-9 human malignant glioma cells. CuZnSOD activity levels increased 1.5-, 2.0-, 2.6-, and 3.5-fold, respectively, in four table transfected cell lines compared with wild type and vector controls. Overexpression of CuZnSOD altered cellular antioxidant enzyme profiles, including those of manganese superoxide dismutase, catalase, and GPx. The transfected clone with the highest CuZnSOD:GPx ratio (3.5) showed a 42% inhibition of tumor cell growth in vitro. The decreased rate of tumor cell growth in vitro was strongly correlated with the enzyme activity ratio of CuZnSOD:GPx. Glioma cells that stably overexpressed CuZnSOD demonstrated additional suppressive effects on the malignant phenotype when compared with the parental cells and vector controls. These cells showed decreased plating efficiency, elongated cell population doubling time, lower clonogenic fraction in soft agar, and, more significantly, inhibition of tumor formation in nude mice. This work suggested that CuZnSOD is a new tumor suppressor gene. Increased intracellular ROS levels were found in cells with high activity ratios of CuZnSOD:GPx. Change in the cellular redox status, especially change attributable to the accumulation of hydrogen peroxide or other hydroperoxides, is a possible reason to explain the suppression of tumor growth observed in CuZnSOD-overexpressing cells.
La reforma temporal de la causa de disolución por pérdidas graves (2009)

Se analiza la suspension excepcional, apenas durante los dos ejercicios anuales cerrados a partir del 13 de diciembre de 2008, de los regimenes de reduccion obligatoria del capital por perdidas y de disolucion por perdidas agravadas establecidos con caracter general en la normativa de sociedades, introducida en la Disposicion Adicional Unica del Real Decreto-Ley 10/2008, de 12 de diciembre y su impacto especifico en el sector inmobiliario.
Solid–Liquid Separation, Introduction (2000)

Abstract The article contains sections titled: 1. General Considerations 2. Separation Processes 2.1. Sedimentation 2.2. Filtration
TSH signaling and cell survival in 3T3-L1 preadipocytes (2002)

Thyroid-stimulating hormone (TSH) action in adipose tissue remains largely unknown. Our previous work indicates that human preadipocytes express functional TSH receptor (TSHR) protein, demonstrated by TSH activation of p70 S6 kinase (p70 S6K). We have now studied murine 3T3-L1 preadipocytes to further characterize TSH signaling and cellular action. Western blot analysis of 3T3-L1 preadipocyte lysate revealed the 100-kDa mature processed form of TSHR. TSH activated p70 S6K and protein kinase B (PKB/Akt), as measured by immunoblot analysis. Preincubation with wortmannin or LY-294002 completely blocked TSH activation of p70 S6K and PKB/Akt, implicating phosphoinositide 3-kinase (PI3K) in their regulation. TSH increased phosphotyrosine protein(s) in the 125-kDa region and augmented the associated PI3K activity fourfold. TSH had no effect on cAMP levels in 3T3-L1 preadipocytes, suggesting that adenylyl cyclase is not involved in TSH activation of the PI3K-PKB/Akt-p70 S6K pathway. 3T3-L1 preadipocyte cell death was reduced by 29-76% in serum-deprived (6 h) preadipocytes treated with 1-20 microM TSH. In the presence of 20 microM TSH, an 88% reduction in terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL)-positive cells was observed in serum-starved (3 h) 3T3-L1 preadipocytes as well as a 93% reduction in the level of cleaved activated caspase 3. In summary, TSH acts as a survival factor in 3T3-L1 preadipocytes. TSH does not stimulate cAMP accumulation in these cells but instead activates a PI3K-PKB/Akt-p70 S6K pathway.
Polylog-overhead highly fault-tolerant measurement-based quantum computation: all-Gaussian implementation with Gottesman-Kitaev-Preskill code (2020)

Scalability of flying photonic quantum systems in generating quantum entanglement offers a potential for implementing large-scale fault-tolerant quantum computation, especially by means of measurement-based quantum computation (MBQC). However, existing protocols for MBQC inevitably impose a polynomial overhead cost in implementing quantum computation due to geometrical constraints of entanglement structures used in the protocols, and the polynomial overhead potentially cancels out useful polynomial speedups in quantum computation. To implement quantum computation without this cancellation, we construct a protocol for photonic MBQC that achieves as low as poly-logarithmic overhead, by introducing an entanglement structure for low-overhead qubit permutation. Based on this protocol, we design a fault-tolerant photonic MBQC protocol that can be performed by experimentally tractable homodyne detection and Gaussian entangling operations combined with the Gottesman-Kitaev-Preskill (GKP) quantum error-correcting code, which we concatenate with the $7$-qubit code. Our fault-tolerant protocol achieves the threshold $7.8$ dB in terms of the squeezing level of the GKP code, outperforming $8.3$ dB of the best existing protocol for fault-tolerant quantum computation with the GKP surface code. Thus, bridging a gap between theoretical progress on MBQC and photonic experiments towards implementing MBQC, our results open a new way towards realization of a large class of quantum speedups including those polynomial.
Simple method to improve dynamic range of optical amplifiers in coherent optical communication systems with heterodyne receivers (1991)

The dynamic range of an optical amplifier is increased by reducing the local oscillator spontaneous emission beat noise. A 2.5 dB improvement has been demonstrated experimentally with a simple, all-fibre optical image rejection mixer.