gebhart/patrepeval huggingface dataset:
Allogeneic hematopoietic cell transplantation for primary refractory acute lymphoblastic leukemia: A report from the Acute Leukemia Working Party of the EBMT (2017)

Although overall these patients would clearly benefit from the introduction of novel antileukemic therapies, the data from the current study support the use of allogeneic HCT in selected patients with PREF ALL. Cancer 2017;123:1965-1970. © 2017 American Cancer Society.
Influence of arterial O<sub>2</sub> on the susceptibility to posthyperventilation apnea during sleep (2005)

To investigate the contribution of the peripheral chemoreceptors to the susceptibility to posthyperventilation apnea, we evaluated the time course and magnitude of hypocapnia required to produce apnea at different levels of peripheral chemoreceptor activation produced by exposure to three levels of inspired P(O2). We measured the apneic threshold and the apnea latency in nine normal sleeping subjects in response to augmented breaths during normoxia (room air), hypoxia (arterial O2 saturation = 78-80%), and hyperoxia (inspired O2 fraction = 50-52%). Pressure support mechanical ventilation in the assist mode was employed to introduce a single or multiple numbers of consecutive, sigh-like breaths to cause apnea. The apnea latency was measured from the end inspiration of the first augmented breath to the onset of apnea. It was 12.2 +/- 1.1 s during normoxia, which was similar to the lung-to-ear circulation delay of 11.7 s in these subjects. Hypoxia shortened the apnea latency (6.3 +/- 0.8 s; P < 0.05), whereas hyperoxia prolonged it (71.5 +/- 13.8 s; P < 0.01). The apneic threshold end-tidal P(CO2) (Pet(CO2)) was defined as the Pet(CO2)) at the onset of apnea. During hypoxia, the apneic threshold Pet(CO2) was higher (38.9 +/- 1.7 Torr; P < 0.01) compared with normoxia (35.8 +/- 1.1; Torr); during hyperoxia, it was lower (33.0 +/- 0.8 Torr; P < 0.05). Furthermore, the difference between the eupneic Pet(CO2) and apneic threshold Pet(CO2) was smaller during hypoxia (3.0 +/- 1.0 Torr P < 001) and greater during hyperoxia (10.6 +/- 0.8 Torr; P < 0.05) compared with normoxia (8.0 +/- 0.6 Torr). Correspondingly, the hypocapnic ventilatory response to CO2 below the eupneic Pet(CO2) was increased by hypoxia (3.44 +/- 0.63 l.min(-1).Torr(-1); P < 0.05) and decreased by hyperoxia (0.63 +/- 0.04 l.min(-1).Torr(-1); P < 0.05) compared with normoxia (0.79 +/- 0.05 l.min(-1).Torr(-1)). These findings indicate that posthyperventilation apnea is initiated by the peripheral chemoreceptors and that the varying susceptibility to apnea during hypoxia vs. hyperoxia is influenced by the relative activity of these receptors.
A hallmark of immunoreceptor, the tyrosine‐based inhibitory motif ITIM, is present in the G protein‐coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism (2008)

Orexins acting at the G protein-coupled receptor (GPCR) OX1R have recently been shown to promote dramatic apoptosis in cancer cells. We report here that orexin-induced apoptosis is driven by an immunoreceptor tyrosine-based inhibitory motif (ITIM) (IIY(358)NFL) present in the OX1R. This effect is mediated by SHP-2 phosphatase recruitment via a mechanism that requires Gq protein but is independent of phospholipase C activation. This is based on the following observations: 1) mutation of Y(358) into F abolished orexin-induced tyrosine phosphorylation in ITIM, orexin-induced apoptosis, and uncoupled OX1R from Gq protein in transfected Chinese hamster ovary (CHO) cells; 2) orexin-induced apoptosis in CHO cells expressing recombinant OX1R and in colon cancer cells expressing the native receptor was abolished by treatment with the tyrosine phosphatase inhibitor PAO and by transfection with a dominant-negative mutant of SHP-2; 3) orexins were unable to promote apoptosis in fibroblast cells invalidated for the G alpha q subunit and transfected with OX1R cDNA, whereas they promoted apoptosis in cells equipped with G alpha q and OX1R; and 4) the phospholipase C inhibitor U-73122 blocked orexin-stimulated inositol phosphate formation, whereas it had no effect on orexin-induced apoptosis in CHO cells expressing OX1R. These data unravel a novel mechanism, whereby ITIM-expressing GPCRs may trigger apoptosis.
CMOS On-Chip Stable True-Random ID Generation Using Antenna Effect (2013)

A CMOS on-chip ID generation scheme is proposed. Using the antenna effect during the chip fabrication, one gate in a transistor pair is physically randomly broken down due to the process variation and an on-chip ID number is thus created depending on its polarity. The generated ID not only is permanently immune from environment changes such as supply voltage and temperature, but also consumes ultra-low leakage power without any dynamic transitions. The functionality of the proposed ID generation scheme has been experimentally verified by a fabricated chip in 0.18 μm CMOS process.
Población extranjera en Deir el-Medina: Documentos y problemas de identificación (D. XVIII-XIX) (2009)

Deir el-Medina proporciona un amplio corpus documental que nos permite conocer el funcionamiento, la administracion y la organizacion de la comunidad, asi como estudiar en profundidad algunos aspectos especificos de su historia. Este articulo se centra en uno de esos aspectos: la presencia de poblacion extranjera entre los trabajadores vinculados con la comunidad durante las dinastias XVIII y XIX (c. 1450-1186 a.C.). La investigacion pretende preguntarse quienes fueron estos extranjeros, cual era su estatus, cual era su relacion con el resto de la comunidad y cual fue su grado de integracion social en el poblado.
Narrow-Band Thermal Radiation with Low Directivity by Resonant Modes inside Tungsten Microcavities (2004)

Narrow-band thermal radiation with low directivity is presented using a periodic array of microcavities on tungsten surfaces. Thermally excited resonant modes inside the microcavities are found to enhance thermal radiation at specific wavelengths. Compared with a flat tungsten surface, thermal radiation from the microcavities has been enhanced by ∼200% at the most enhanced wavelength of λ=5.5 µm. This strong enhancement yields narrow-band thermal radiation with a full width at half maximum of Δλ=0.59 µm. The enhancement peak positions are well explained using a simple cavity resonator model. By measuring thermal radiation at oblique directions, it is also found that this narrow-band radiation has low directivity.
Cu and Co exchanged ZSM-5 zeolites: activity towards no reduction and hydrocarbon oxidation (2006)

|Cu x|[Si yAl]-MFI and |Co x|[Si yAl]-MFI catalysts were prepared by ion exchange from |Na|[Si yAl]-MFI zeolites (y = 12, 25 and 45). The activity of the catalysts was evaluated in the reduction of NO to N2 in an oxidative atmosphere using propane or methane as reducing agents. The Cu catalysts were only active with propane and they presented higher activity than the Co-based catalysts, the latter being active with both hydrocarbons. H2-TPR and DRS-UV/Vis data allowed correlation between the activity towards NO reduction and the presence of cationic charge-compensating species in the zeolite. It was also verified that the hydrocarbons are preferentially oxidised by O2, a reaction that occurs simultaneously with their oxidation with NO.
ACOUSTICAL HOLOGRAPHY OF NONEXISTENT WAVEFRONTS DETECTED AT A SINGLE POINT IN SPACE (1968)

An experiment is described in which a hologram is recorded by scanning the source and having the detector stationary. The resulting ``scanned source'' hologram is shown to be identical to the conventional ``scanned detector'' hologram. The significance of this experiment is that it demonstrates: (1) that sampled holograms of an object can be recorded at a single point in space with either a scanning source or an array of sources; (2) that the object wavefront need not actually exist in space but may be geometrically synthesized; (3) that the object may be illuminated by a changing rather than stationary wave field. The interesting possibilities which this configuration gives rise to are briefly discussed.
Risk Factors for Developing Active Tuberculosis After the Treatment of Latent Tuberculosis in Adults Infected With Human Immunodeficiency Virus (2014)

Tuberculosis is the leading cause of death among adults infected with human immunodeficiency virus (HIV), and rates of tuberculosis remain high even after preventive therapy. Among 908 HIV-infected adults in a trial of preventive treatment, we found self-reported alcohol consumption, low baseline CD4 count, high baseline viral load, and tuberculin skin test size >15 mm as independent risk factors for incident tuberculosis.
Prediction of digestible energy value of extruded dog food: comparison of methods (2008)

The proposal of National Research Council (NRC), based on the use of modified Atwater factors, is nowadays the widely used method to estimate digestible energy (DE) content of pet foods. Recently, alternative methods have been suggested for predicting energy content of commercial canine dry food. Factorial equations including food fibre content as estimator, in vitro digestions methods or near-infrared spectroscopy (NIRS) techniques have been considered as good approaches to predict the energy content of dog foods. The aim of this study was to compare the accuracy of some of those estimation methods. Seventeen samples of commercial extruded dog food were used to validate and compare some estimation methods of energy digestibility (Ed, %) and DE value [MJ/kg dry matter (DM)]. The apparent Ed and DE of each food were previously determined by in vivo trials. In vivo Ed and DE of foods ranged from 79.30% to 91.05% and from 16.25 to 21.82 MJ/kg DM, respectively, and their crude fibre (CF) content ranged from 0.72% to 3.28% (in DM base). The % Ed of each sample was estimated by the factorial equation (% Ed = 91.2 - 1.43 x CF %) and by the in vitro digestion method [% Ed(in vitro) = -2.45 + 0.98 organic matter (OM) disappearance(in vitro)%]. The set of samples also was analysed by NIRS, using a calibration equation developed from a set of 69 samples of commercial extruded dog food (0.76 and 0.89 cross-validation r(2) and 2.33 and 0.61 cross-validation SE for Ed and DE respectively). The in vitro method gave better estimations of Ed in vivo than NIRS and factorial methods, although all the methods assessed showed a very good and similar accuracy in the prediction of DE value. These three methods showed a slight better accuracy than that previously proposed by the NRC. To consider constant digestibility values of nutrient content of food can result in bias and error in the estimated energy values. The alternative prediction methods used in this study take into account differences of ingredient composition and availability of nutrients of different extruded dog foods thus could be better systems of valuating energy content in a wider range of different kind of foods than in use method.
Developmental regulation of the expression of 1-aminocyclopropane-1-carboxylic acid (ACC) synthase and ACC oxidase genes in hypocotyls of etiolated mung bean seedlings (2004)

Differential expression of seven 1-aminocyclopropane-1-carboxylate (ACC) synthase and two ACC oxidase genes during the developmental process was investigated in etiolated mung bean seedlings. Among these genes, VR-ACS1, VR-ACS6, VR-ACS7, VR-ACO1, and VR-ACO2 were expressed in the subhook regions of hypocotyls. Except for VR-ACO1, the expression levels of these genes were correlated with the amount of ethylene produced. VR-ACO1 expression was largely constitutive. During hypocotyl growth, the expression of VR-ACS1, VR-ACS6, and VR-ACS7 was maintained at a high level. After the growth stopped, their expression levels became negligible, but the decrease in the VR-ACO2 transcript was much slower. These results suggest that the expression of each of the five genes in the subhook regions of hypocotyls is kinetically distinct, temporally and spatially regulated, and especially high in the tissues of rapidly elongating cells. However, endogenously produced ethylene had no stimulating effect on the growth of hypocotyls or roots. The expression of each of the five genes detected in intact hypocotyls was inducible with auxin. The expression of auxin-inducible VR-ACS1 and VR-ACS6 was negatively regulated in the presence of auxin action and transport inhibitors. However, the transcripts of VR-ACS7, VR-ACO1, and VR-ACO2 were rarely influenced by the treatment of these inhibitors. These results suggest that additional growth factor(s), besides auxin, was (were) involved in the regulation of endogenous ethylene synthesis in etiolated mung bean seedlings.
Spiral inductor performance in deep-submicron bulk-CMOS with copper interconnects (2003)

This paper reviews design considerations for spiral inductors in bulk CMOS and reports investigations carried out in a commercial 0.18 /spl mu/m process using 6-layer copper metalization. Quality factors of approximately 8 are measured for 10 nH spirals operating between 1 and 2 GHz. Comparisons of Q and self-resonant frequency are provided for a variety of construction variables including with/without a patterned ground shield, metal-6 only versus stacking layers 3 thru 6, dense versus sparse vias, wide versus narrow traces, and with/without metal-fill.
Photodynamic therapy in Barrett's esophagus: Reduction of specialized mucosa, ablation of dysplasia, and treatment of superficial esophageal cancer (1995)

Twelve patients with Barrett's esophagus and dysplasia were treated with photodynamic therapy. Five patients also had early, superficial esophageal cancers and five had esophageal polyps. Light was delivered via a standard diffuser or a centering esophageal balloon. Patients were maintained on omeprazole and followed for 6-54 months. In patients with Barrett's esophagus, photodynamic therapy ablated dysplastic mucosa and malignant mucosa in patients with superficial cancer. Healing and partial replacement of Barrett's mucosa with normal squamous epithelium occurred in all patients and complete replacement with squamous epithelium was found in three patients. Side effects included photosensitivity and mild-moderate chest pain and dysphagia for 5-7 days. In four patients with extensive circumferential mucosal ablation in the mid or proximal esophagus, healing was associated with esophageal strictures which were treated successfully by esophageal dilation. Strictures were not found in the distal esophagus. Photodynamic therapy combined with long-term acid inhibition provides effective endoscopic therapy of Barrett's mucosal dysplasia and superficial (Tis-T1) esophageal cancer. The windowed centering balloon improves delivery of photodynamic therapy to diffusely abnormal esophageal mucosa.
Fabrication of tungsten nanocrystals and silver–tungsten nanonets: a potent reductive catalyst (2015)

Ag–W bimetallic plasmonic heterostructures were synthesized with tunable LSPR properties over the full solar spectrum region and exploited in reduction catalytic processes driven by light energy.
Physical and Leisure Activity in Older Community-Dwelling Canadians Who Use Wheelchairs: A Population Study (2011)

Background. Physical and leisure activities are proven health promotion modalities and have not been examined in older wheelchair users. Main Objectives. Examine physical and leisure activity in older wheelchair users and explore associations between wheelchair use and participation in physical and leisure activity, and wheelchair use, physical and leisure activity, and perceived health. Methods. 8301 Canadians ≥60 years of age were selected from the Canadian Community Health Survey. Sociodemographic, health-related, mobility-related, and physical and leisure activity variables were analysed using logistic regression to determine, the likelihood of participation in physical and leisure activity, and whether participation in physical and leisure activities mediates the relationship between wheelchair use and perceived health. Results. 8.3% and 41.3% older wheelchair users were physically and leisurely active. Wheelchair use was a risk factor for reduced participation in physical (OR = 44.71) and leisure activity (OR = 10.83). Wheelchair use was a risk factor for poor perceived health (OR = 10.56) and physical and leisure activity negatively mediated the relationship between wheelchair user and perceived health. Conclusion. There is a need for the development of suitable physical and leisure activity interventions for older wheelchair users. Participation in such interventions may have associations with health benefits.
Early treatment with combination of SS31 and entresto effectively preserved the heart function in doxorubicin-induced dilated cardiomyopathic rat (2021)

Combined SS31-En therapy was superior to either one alone on protecting the heart structural and functional integrities against Dox-induced DCM damage.
Early Effects of Extracorporeal Shock Wave Treatment on Osteoblast-like Cells: A Comparative Study Between Electromagnetic and Electrohydraulic Devices (2006)

The use of the electromagnetic device and a level of EFD lower than 0.40 mJ/mm2 would appear to induce fewer immediate cytodestructive effects and better stimulate subsequent proliferation and the synthetic activity of MG63.
Compact echelle spectrometer employing a cross-grating (2018)

The concept and the implementation of a compact and simplified echelle spectrometer are presented, and the working principle is demonstrated by first experimental measurements. The crucial element of the setup is a cross-grating, combining an echelle grating utilizing several higher diffraction orders (5th up to 11th) and a superposed perpendicular-oriented cross-dispersing grating. Two alternative manufacturing approaches for the cross-grating are presented and discussed. The first approach combines Talbot lithography for the deep echelle grating and interference lithography for the cross-dispersing structure. As a second approach, direct laser-beam writing was applied. The compact echelle spectrometer covers a spectral range from 380 to 700 nm and offers a spectral resolution of ∼2 <i>nm</i>.
Four species of the family Noctuidae (Lepidoptera) New to Korea (2006)

In the present study, we reports four species of Noctuidae are reported for the first time from Korea: Hadennia obliqua (Wileman), Zanclognatha lui Han and Park, Premusia intrahens Walker, and Cucullia hostilis Broursin. The adults and genital characteristics of the species are briefly redescribed with illustrations and their biological and distributional notes are given as necessary.
Air-gap transmission lines for multiprocessor interconnects on FR-4 and BT substrates (2007)

The fabrication and characterization of low loss parallel plate and microstrip lines with an air dielectric layer is described. The lines are characterized by capacitance and loss tangent at 10 kHz and 100 kHz and by S-parameters up to 10 GHz. The inclusion of the air-gap significantly reduced the loss tangent and lowered the dielectric constant to between 1.5 and 1.8. More complicated transmission line structures could be fabricated using the described techniques.
Adenosine Diphosphate (ADP) and ADP Receptor Play a Major Role in Platelet Activation/Aggregation Induced by Sera From Heparin-Induced Thrombocytopenia Patients (1998)

The molecular basis for heparin-induced thrombocytopenia (HIT), a relatively common complication of heparin therapy, is not yet fully understood. We found that pretreatment of platelets with AR-C66096 (formerly FPL 66096), a specific platelet adenosine diphosphate (ADP) receptor antagonist, at a concentration of 100 to 200 nmol/L that blocked ADP-dependent platelet aggregation, resulted in complete loss of platelet aggregation responses to HIT sera. AR-C66096 also totally inhibited HIT serum-induced dense granule release, as judged by measurement of adenosine triphosphate (ATP) release. Apyrase, added to platelets at a concentration that had only minor effects on thrombin- or arachidonic acid-induced aggregation, also blocked completely HIT serum-induced platelet aggregation. Furthermore, AR-C66096 inhibited platelet aggregation and ATP release induced by cross-linking FcγRIIA with specific antibodies. These data show that released ADP and the platelet ADP receptor play a pivotal role in HIT serum-induced platelet activation/aggregation. The thromboxane receptor inhibitor, Daltroban, had no effect on HIT serum-induced platelet activation whereas GPIIb-IIIa antagonists blocked platelet aggregation but had only a moderate effect on HIT serum-induced dense granule release. Pretreatment of platelets with chondroitinases but not with heparinases resulted in concentration dependent inhibition of HIT serum-induced platelet aggregation. These novel data relating to the mechanism of platelet activation induced by HIT sera suggest that the possibility should be examined that ADP receptor antagonists or compounds that inhibit ADP release may be effective as therapeutic agents for the prevention or treatment of complications associated with heparin therapy.
Instruction Code Compression for Application Specific VLIW Processors Based on Automatic Field Partitioning (2007)

This paper presents a method of reducing the instruction memory size of application specific VLIW processors. Given an object code of a processor, we try to compress it by recoding each instruction word with a smaller number of bits. The problem of finding a good coding which achieves large reduction and yet curbs the size and the delay of the decoder is reduced to the problem of finding a good field partitioning. By establishing a relation between a field partition and the cost of the program and decoders, we formulate an optimum field partitioning problem in which a field partition minimizing the cost of the program and the decoder is sought. We have developed an approximation algorithm to solve this problem. In a preliminary experiment on three sets of practical VLIW processors and application programs, the total objective cost, which is defined as the sum of the total bits of the coded program and the size of the ROMs to implement the decoder, is reduced into 46%∼60% of the original ones.
Synthesis of 2-Alkylaminoethanols from Ethanolamine (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 2-Alkylaminoethanols from EthanolamineArthur C. Cope and Evelyn M. HancockCite this: J. Am. Chem. Soc. 1942, 64, 7, 1503–1506Publication Date (Print):July 1, 1942Publication History Published online1 May 2002Published inissue 1 July 1942https://pubs.acs.org/doi/10.1021/ja01259a005https://doi.org/10.1021/ja01259a005research-articleACS PublicationsRequest reuse permissionsArticle Views737Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts