gebhart/patrepeval huggingface dataset:
Molecular Amplification and Generation of Microwaves (1957)

This paper is a general introduction to the field of amplification and generation of microwaves using molecular rather than electronic processes. The basic physical properties of molecular systems as related to amplification are reviewed. The properties of molecular amplifiers, such as gain, bandwidth, saturation power, and noise figure are discussed, and several specific types of amplifiers are described. These include the molecular-beam Maser, the "hot-grid cell," amplifiers excited by rf pulses and by "adiabatic fast passage," and amplifiers based on multilevel molecular internal energy systems, including "optically pumped" amplifiers. Molecular amplifiers may add very little noise to the signal to be amplified: noise figures under one db can be obtained. With suitable feedback, such amplifiers become oscillators of extremely high spectral purity. High gains can be achieved using regeneration, but bandwidths are relatively small. These range from the order of tens of kilocycles for amplifiers using a gaseous molecular system, to megacycles, using solids. Molecular amplifiers saturate at low input powers, of the order of microwatts. Variations of the devices discussed may provide a means of generating millimeter and submillimeter waves.
<i>In vitro</i>assays and biomarkers for drug-induced phospholipidosis (2006)

Drug-induced phospholipidosis is the cytoplasmic accumulation of phospholipids as a result of xenobiotic exposure. This accumulation results in a unique histological effect in cells noted as electron-dense lamellar inclusions or whorls in the cytoplasm when observed with transmission electron microscopy. Electron microscopy has been the widely accepted standard for classification of the phospholipidosis effect. Molecules that have been prone to induce such an effect are made up of a lipophilic region and a positively charged region. Phospholipidosis has most commonly been associated with drugs that are cationic, amphiphilic drugs and can occur in a variety of tissues. Although phospholipidosis is not considered adverse in isolation, depending on the tissue affected or the occasional circumstance of concurrent toxicity, phospholipidosis can be perplexing if identified in early drug development. In most circumstances, characterisation of the effect with in vivo studies allows for determination of exposure and the magnitude of the effect. On occasion in drug development, there may be an interest to screen early stage compounds to minimise phospholipidosis. In such circumstances, in silico and in vitro assays can be employed in a strategy with in vivo assessments. In addition, there may be an interest to monitor for the potential development of phospholipidosis in longer-term animal studies. In such cases, biomarker approaches could be used. The challenge in the overall assessment of phospholipidosis remains the question of the possible relevance to any toxicity, and, therefore, any screening approach, while assessing the potential to induce phospholipidosis, must be considered in relation to prediction of findings in vivo. The status of current assays and biomarkers is presented with strategies for screening.
Modular architectures for two-dimensional digital signal processing (1988)

The implementation of highly modular two-dimensional (2-D) digital filters is addressed. The idea of matrix decomposition is used to provide increased parallelism and regularity. Four different structures, namely, the transversal, the distributed arithmetic, the stored product, and the systolic array, are considered. For comparison purposes, the direct implementation is included. An analysis of each of each is performed and comparisons are made in terms of hardware cost, cycle time, finite register length effects, and regularity. It is found that the systolic array structure seems to offer the best compromise among the various conflicting figures of merit. The distributed arithmetic structure is shown to be superior in the case of low-order filters, while the stored product structure is preferable for high-order filters. The inherent parallelism and high throughput rate of these structures make them suitable for real-time image processing applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Magic-Angle Spinning NMR of Cold Samples (2013)

Magic-angle-spinning solid-state NMR provides site-resolved structural and chemical information about molecules that complements many other physical techniques. Recent technical advances have made it possible to perform magic-angle-spinning NMR experiments at low temperatures, allowing researchers to trap reaction intermediates and to perform site-resolved studies of low-temperature physical phenomena such as quantum rotations, quantum tunneling, ortho-para conversion between spin isomers, and superconductivity. In examining biological molecules, the improved sensitivity provided by cryogenic NMR facilitates the study of protein assembly or membrane proteins. The combination of low-temperatures with dynamic nuclear polarization has the potential to boost sensitivity even further. Many research groups, including ours, have addressed the technical challenges and developed hardware for magic-angle-spinning of samples cooled down to a few tens of degrees Kelvin. In this Account, we briefly describe these hardware developments and review several recent activities of our group which involve low-temperature magic-angle-spinning NMR. Low-temperature operation allows us to trap intermediates that cannot be studied under ambient conditions by NMR because of their short lifetime. We have used low-temperature NMR to study the electronic structure of bathorhodopsin, the primary photoproduct of the light-sensitive membrane protein, rhodopsin. This project used a custom-built NMR probe that allows low-temperature NMR in the presence of illumination (the image shows the illuminated spinner module). We have also used this technique to study the behavior of molecules within a restricted environment. Small-molecule endofullerenes are interesting molecular systems in which molecular rotors are confined to a well-insulated, well-defined, and highly symmetric environment. We discuss how cryogenic solid state NMR can give information on the dynamics of ortho-water confined in a fullerene cage. Molecular motions are often connected with fundamental chemical properties; therefore, an understanding of molecular dynamics can be important in fields ranging from material science to biochemistry. We present the case of ibuprofen sodium salt which exhibits different degrees of conformational freedom in different parts of the same molecule, leading to a range of line broadening and line narrowing phenomena as a function of temperature.
<title>Alignment System Devices For Medium Repetition Rate Glass Fusion Lasers</title> (1980)

The OMEGA laser irradiation facility consists of a 24 arm Neodymium glass laser coupled to a spherical target irradiation chamber. A computer network is connected to the laser and target systems through a control room where operators can access any of the devices or subsystems within the facility. The facility is designed to produce 12 terawatt laser pulses and irradiate various materials to study laser-matter interactions at extremely high peak power. The system is capable of sustaining one target shot every 30 minutes.
Development of epigallocatechin gallate-eluting polymeric stent and its physicochemical, biomechanical and biological evaluations (2009)

Localized drug delivery from drug-eluting stents has been accepted as one of the most promising treatment methods for preventing restenosis after stenting. However, hypersensitivity reactions caused by their nonresorbable polymer coatings and bare-metal stents may result in serious clinical sequelae. Epigallocatechin-3-O-gallate (EGCG), the predominant catechin from tea, has been shown to exert anti-thrombotic, anti-inflammatory and anti-proliferative activities. In this study, it was hypothesized that sustainedly released EGCG from biodegradable poly(lactide-co-epsilon-caprolactone, PLCL) would suppress the proliferation of vascular smooth muscle cells (VSMCs). EGCG-releasing PLCL (E-PLCL) was prepared by blending PLCL with EGCG. The surface morphology, roughness and melting temperature of PLCL were not changed despite EGCG addition. EGCG was uniformly dispersed into E-PLCL and sustainedly released for periods up to 7 days by controlled diffusion rather than PLCL degradation. Moreover, EGCG did not affect tensile strength at break, but significantly increased the elastic modulus of PLCL. The proliferation of VSMCs onto E-PLCL was significantly suppressed although the cell attachment onto E-PLCL had been higher than that onto PLCL. On the other hand, EGCG-eluting polymeric stents were prepared with neither cracks nor webbings between struts, and their structural integrity was maintained without delamination or destruction. These results suggest that E-PLCL can be potentially applied for fabricating an EGCG-eluting vascular stent, namely an EGCG-eluting polymeric stent, or even an EGCG-releasing polymer-coated metal stent, to prevent thrombosis, inflammation and in-stent restenosis.
TaqMan PCR for Detection of <i>Vibrio cholerae</i> O1, O139, Non-O1, and Non-O139 in Pure Cultures, Raw Oysters, and Synthetic Seawater (2001)

Vibrio cholerae is recognized as a leading human waterborne pathogen. Traditional diagnostic testing for Vibrio is not always reliable, because this bacterium can enter a viable but nonculturable state. Therefore, nucleic acid-based tests have emerged as a useful alternative to traditional enrichment testing. In this article, a TaqMan PCR assay is presented for quantitative detection of V. cholerae in pure cultures, oysters, and synthetic seawater. Primers and probe were designed from the nonclassical hemolysin (hlyA) sequence of V. cholerae strains. This probe was applied to DNA from 60 bacterial strains comprising 21 genera. The TaqMan PCR assay was positive for all of the strains of V. cholerae tested and negative for all other species of Vibrio tested. In addition, none of the other genera tested was amplified with the TaqMan primers and probe used in this study. The results of the TaqMan PCR with raw oysters and spiked with V. cholerae serotypes O1 and O139 were comparable to those of pure cultures. The sensitivity of the assay was in the range of 6 to 8 CFU g(-1) and 10 CFU ml(-1) in spiked raw oyster and synthetic seawater samples, respectively. The total assay could be completed in 3 h. Quantification of the Vibrio cells was linear over at least 6 log units. The TaqMan probe and primer set developed in this study can be used as a rapid screening tool for the presence of V. cholerae in oysters and seawater without prior isolation and characterization of the bacteria by traditional microbiological methods.
Endothelin Blockade in Diabetic Kidney Disease (2015)

Diabetic kidney disease (DKD) remains the most common cause of chronic kidney disease and multiple therapeutic agents, primarily targeted at the renin-angiotensin system, have been assessed. Their only partial effectiveness in slowing down progression to end-stage renal disease, points out an evident need for additional effective therapies. In the context of diabetes, endothelin-1 (ET-1) has been implicated in vasoconstriction, renal injury, mesangial proliferation, glomerulosclerosis, fibrosis and inflammation, largely through activation of its endothelin A (ETA) receptor. Therefore, endothelin receptor antagonists have been proposed as potential drug targets. In experimental models of DKD, endothelin receptor antagonists have been described to improve renal injury and fibrosis, whereas clinical trials in DKD patients have shown an antiproteinuric effect. Currently, its renoprotective effect in a long-time clinical trial is being tested. This review focuses on the localization of endothelin receptors (ETA and ETB) within the kidney, as well as the ET-1 functions through them. In addition, we summarize the therapeutic benefit of endothelin receptor antagonists in experimental and human studies and the adverse effects that have been described.
Identification of Ventricular Enlargement and Estimation of Intracranial Pressure by Transcranial Color‐Coded Real‐Time Sonography (1994)

Transcranial color-coded real-time sonography (TCCS) was applied to 26 patients with ventricular enlargement to quantify the ventricular size and to estimate intracranial pressure. Intracranial pressures, as determined by lumbar, epidural, or ventricular tonometry, ranged from 6.5 to 55 cm H2O (8 patients had pressures > 18 cm H2O). The widths of the third ventricle and the frontal horns of both lateral ventricles depicted by TCCS were compared to corresponding computed tomography data: TCCS and computed tomography findings correlated well for the third ventricle (r = 0.96) and for the right (r = 0.86) and left (r = 0.92) frontal horns. The capability of the septum pellucidum to undulate relative to the ventricular wall during short (20-degree) rotatory movements of the head was related to intracranial pressure. In all patients with intracranial pressure below 17 cm H2O, rotatory head movements induced septum pellucidum undulation; no lateral deflection of the septum pellucidum was found in patients with an intracranial pressure above 21 cm H2O. Therefore, TCCS may be employed to quantify and follow-up ventricular enlargement. Dynamic neurosonographic tests may allow a gross estimation of intracranial pressure.
Chemical Diffusion in Polycrystalline Al <sub>2</sub> O <sub>3</sub> (1980)

Chemical diffusion in poly crystalline α‐Al 2 O 3 doped with Ti or Fe was studied through the movement of a color front on oxidation of reduced samples. The diffusion is faster in polycrystal‐line than in single‐crystal material. The oxygen pressure dependence of the rate of diffusion indicates that neutral interstitial oxygen is the major mobile species at the grain boundaries. A theory is presented which accounts for the data and explains the difference in the rates of oxidation and reduction and their dependence on oxygen pressure. Grain boundaries with precipitates of FeAl 2 O 4 or TiAl 2 O 5 appear to transport oxygen faster than clean boundaries.
Significance of minimal residual disease before myeloablative allogeneic hematopoietic cell transplantation for AML in first and second complete remission (2013)

Minimal residual disease (MRD) before myeloablative hematopoietic cell transplantation (HCT) is associated with adverse outcome in acute myeloid leukemia (AML) in first complete remission (CR1). To compare this association with that for patients in second complete remission (CR2) and to examine the quantitative impact of MRD, we studied 253 consecutive patients receiving myeloablative HCT for AML in CR1 (n = 183) or CR2 (n = 70) who had pre-HCT marrow aspirates analyzed by 10-color flow cytometry. Three-year estimates of overall survival were 73% (64%-79%) and 32% (17%-48%) for MRDneg and MRDpos CR1 patients, respectively, and 73% (57%-83%) and 44% (21%-65%) for MRDneg and MRDpos CR2 patients, respectively. Similar estimates of relapse were 21% (14%-28%) and 58% (41%-72%) for MRDneg and MRDpos CR1 patients, respectively, and 19% (9%-31%) and 68% (41%-85%) for MRDneg and MRDpos CR2 patients, respectively. Among the MRDpos patients, there was no statistically significant evidence that increasing levels of MRD were associated with increasing risks of relapse and death. After multivariable adjustment, risks of death and relapse were 2.61 times and 4.90 times higher for MRD(pos) patients (P < .001). Together, our findings indicate that the negative impact of pre-HCT MRD is similar for AML in CR1 and CR2 with even minute levels (≤ 0.1%) as being associated with adverse outcome.
The predictive value of tympanometry in the diagnosis of middle ear effusion (1997)

Over a 12-month period 501 children (age range 11 months to 15 years) underwent surgery for a possible middle ear effusion. All had tympanometry performed within 2 h of surgery. The results of tympanometry were correlated with the surgical findings in 955 ears. A type-B tympanogram has a high sensitivity (0.91) in predicting middle ear effusion with good specificity (0.79). A type-A tympanogram has a very high specificity (0.99) in predicting a dry middle ear but low sensitivity (0.34). Both the positive (0.91) and negative (0.84) predictive values of a type-A tympanogram are high. The addition of a type-C tympanogram increases the sensitivity of predicting a dry middle ear to 0.79. The positive predictive value of a peaked (type-A or -C) tympanogram is 0.71 and should be considered strong evidence that the middle ear is dry. Tympanometry is the best clinical test for the presence or absence of a middle ear effusion, and on the basis of preoperative tympanometry alone the need for surgery should be carefully reassessed.
Picosecond coherence time measurement with a double slit (1987)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text James A. Cobble, "Picosecond coherence time measurement with a double slit," Appl. Opt. 26, 4048-4051 (1987) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Using smart triggers for improved user performance in 802.11 wireless networks (2006)

The handoff algorithms in the current generation of 802.11 networks are primarily reactive in nature, because they wait until the link quality degrades substantially to trigger a handoff. They further rely on instantaneous signal strength measurements when choosing the best AP. This approach leads to handoff delays on the order of 1-2 seconds that are unacceptable for delay sensitive applications such as VoIP. We propose a fundamentally new approach to handoffs that is based on continuous monitoring of wireless links. In our approach, a client measures the beacon strengths of all the APs operating on the current, and the overlapping channels, and makes its handoff decisions based on the long-term, and short-term trends in these signals. We show through experiments in a campus wireless network that our proposed algorithms result in more than 50% reduction in average handoff delays, while having the potential to improve overall user performance. Our algorithms have been implemented in today's hardware, and unlike other proposed roaming algorithms in the literature, need no infrastructure support.
Cache coherence for scalable shared memory multiprocessors (1992)

Shared memory multiprocessors have become an important form of computer systems. Such systems have multiple processors, each of which can access the shared main memory in the system. If each processor has an associated cache, copies of the same data may be present in multiple caches at the same time. This results in the important cache coherence problem, namely, when a processor writes to the data, the multiple copies need to be kept consistent.
In this thesis we present some solutions to the cache coherence problem and discuss their advantages and disadvantages. A new Singly-linked Distributed Directory (SDD) cache coherence protocol is presented. The SDD protocol uses a linked list of cache lines that contain shared copies of the data to maintain coherence. The protocol has scalable cost. The protocol does not require coherency related messages to be delivered in order, and thus allows adaptive routing, making the performance more robust in the presence of congested networks. We have defined an efficient implementation of locks that integrates well with the cache coherence protocol.
We compare the performance of the SDD protocol with a fully mapped centralized directory protocol and the IEEE SCI Standard protocol. The SDD protocol has generally lower interconnect traffic than the other two protocols. Our analysis shows that the SDD protocol has better performance in the presence of memory and interconnect contention. The serial invalidations used by the SDD protocol have been included as part of the optimizations of the SCI protocol in order to reduce the interconnect traffic for invalidations. We discuss the various factors, such as memory reference behavior and interconnect traffic, that affect the performance of these protocols. The cost and performance benefits of the SDD protocol make it a viable solution to the cache coherence problem in large scale shared memory multiprocessors.
Unsupervised Machine Translation Using Monolingual Corpora Only (2017)

Machine translation has recently achieved impressive performance thanks to recent advances in deep learning and the availability of large-scale parallel corpora. There have been numerous attempts to extend these successes to low-resource language pairs, yet requiring tens of thousands of parallel sentences. In this work, we take this research direction to the extreme and investigate whether it is possible to learn to translate even without any parallel data. We propose a model that takes sentences from monolingual corpora in two different languages and maps them into the same latent space. By learning to reconstruct in both languages from this shared feature space, the model effectively learns to translate without using any labeled data. We demonstrate our model on two widely used datasets and two language pairs, reporting BLEU scores of 32.8 and 15.1 on the Multi30k and WMT English-French datasets, without using even a single parallel sentence at training time.
MIMO Radar with Widely Separated Antennas (2008)

MIMO (multiple-input multiple-output) radar refers to an architecture that employs multiple, spatially distributed transmitters and receivers. While, in a general sense, MIMO radar can be viewed as a type of multistatic radar, the separate nomenclature suggests unique features that set MIMO radar apart from the multistatic radar literature and that have a close relation to MIMO communications. This article reviews some recent work on MIMO radar with widely separated antennas. Widely separated transmit/receive antennas capture the spatial diversity of the target's radar cross section (RCS). Unique features of MIMO radar are explained and illustrated by examples. It is shown that with noncoherent processing, a target's RCS spatial variations can be exploited to obtain a diversity gain for target detection and for estimation of various parameters, such as angle of arrival and Doppler. For target location, it is shown that coherent processing can provide a resolution far exceeding that supported by the radar's waveform.