gebhart/patrepeval huggingface dataset:
Engineered, thermoresponsive, magnetic nanocarriers of oligo(ethylene glycol)-methacrylate-based biopolymers (2014)

Engineered magnetic nanocarriers offer attractive options for implementing novel therapeutic solutions in biomedical research; however lack of biocompatibility and external tunability have prevented a biomedical breakthrough. Here we report multifunctional, magnetic nanospheres with tailored size, volumetric transition range, and magnetic properties based on biocompatible, thermo-responsive oligo(ethylene glycol) methacrylate biopolymers. Precise control of the nanosphere size in the range 100–300 nm, coupled with a higher and broader volumetric transition range (32–42 °C), is ideal for various biomedical applications. More importantly, super-paramagnetic behavior of the nanocarriers, even after polymer shell shrinkage, indicates stable and easily controllable loss mechanisms under exposure to an ac magnetic field.
ChemInform Abstract: SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF CIS‐4,5,6,7,8,8A,9‐HEXAHYDRO‐α‐METHYL‐5H‐FLUORENE‐2‐ACETIC ACID (1977)

Abstract Aus dem p‐Brom‐zimtsäureester (I) und Butadien (II) erhält man durch Addition und Hydrierung den 2‐Phenyl‐cyclohexancarbonsäureester (III), aus dem das Cyclisierungsprodukt (IV) erhalten wird.
<i>Lactobacillus acidophilus</i> Expressing Recombinant K99 Adhesive Fimbriae Has an Inhibitory Effect on Adhesion of Enterotoxigenic <i>Escherichia coli</i> (2005)

The most common enteric colibacillosis in neonatal and newborns is caused by enterotoxigenic Escherichia coli(ETEC). Colonization of ETEC in the small intestine is associated with adhesions using fimbriae, which is known as a specific adhesion factor and provides highly specific means for anchoring and prerequisite for an infectious agent. In the present study we have engineered Lactobacillus acidophilus to produce recombinant K99 fimbriae, which is used for the colonization to the intestine of pigs. The expression of K99 fimbrial protein was confirmed using SDS-PAGE, immunoblot and agglutination analyses. To evaluate a function of the K99 fimbrial protein, inhibition and competition tests were performed on pre-screened intestinal brush border from pigs. The tests showed that recombinant L. acidophilus, not control L. acidophilus, had a significant inhibitory effect to and competition against K99+ E. coli in a dose dependent manner. In conclusion, we demonstrated that recombinant K99 fimbriae producing L. acidophilus was able to prevent E. coli binding to intestinal brush border.
Robust signal/noise discrimination for wideband speech and audio coding (2002)

We present a robust discrimination method to separate information carrying signals from ambient noise for wideband coding applications. The method consists of a two-stage procedure. First, a local decision is made based on a set of extracted parameters to update the estimated noise level. The parameters have been chosen to reliably detect speech as well as music signals. Then, the final decision is made based only on a frequency dependent signal to noise ratio (SNR). The noise level update does not depend on the final decision to prevent the discriminator from locking when noise level changes suddenly. The performance is compared with the performance of the voice activity detector (VAD) of G.729, Annex G.
Cancer Therapy: Phenothiazines in an Unexpected Role (1985)

Four lines of evidence (clinical findings, epidemiology, inhibition of tumor growth together with prolongation of survival time, and mechanism of action) which suggest that certain phenothiazines, particularly chlorpromazine, possess a range of anti-neoplastic activities in man and in rodents which has not been generally recognised are reviewed and discussed. Chlorpromazine interferes with energy production in sensitive tumours; the mode of action appears to correspond to autooxidative cellular injury, a common form of cell death.
Hypertension in Long-Term Survivors of Pediatric Hematopoietic Cell Transplantation (2009)

A retrospective study was conducted to determine risk factors for the development of hypertension (HTN) and to describe the prevalence among long-term survivors of pediatric hematopoietic cell transplant (HCT). Records of 689 pediatric patients who survived 5 years or more after HCT, from 1969 to 2004, were reviewed for development of HTN. In children, HTN was defined as either a systolic or diastolic pressure > or =95th percentile according to age, sex, and height. In adults, HTN was defined as systolic pressures > or =140 mmHg and/or diastolic pressures > or =90 mmHg in nondiabetic adults and systolic pressures > or =130 and/or diastolic pressures > or =80 in diabetic adults. Multivariate Cox regression models were used to estimate the hazard ratio (HR) of risk factors associated with HTN. All patients included were off immunosuppressive therapy. Patients had been treated with total body irradiation (TBI) (n = 482, 70%) or non-TBI regimens (n = 207, 30%) followed by autologous (n = 87), related (n = 484), or unrelated donor HCT (n = 118). Median follow-up was 16 (range: 5-36) years. HTN developed in 120 patients with a 30-year cumulative incidence of 36%. Risk factors associated with HTN were acute kidney injury (AKI; doubling of baseline creatinine by day 100 after HCT) (HR = 2.5; 95% confidence interval (CI) 1.7-3.7, P < .0001), TBI in the preparative regimen (HR = 2.1; 95% CI 1.3-3.3, P = .001), donor type (autologous HR = 2.4; 95% CI 1.3-4.4 and unrelated donor HR = 1.8; 95% CI 1.0-3.2, P = .01), obesity (HR = 4.0; 95% CI 2.3-6.8, P < .0001), diabetes (HR = 6.7; 95% CI 3.9-11.0, P < 0.0001), and history of growth hormone therapy (HR = 1.6; 95% CI 1.0-2.5, P = .05). Patients with a positive history of hepatitis C infection were less likely to develop HTN (HR = 0.5; 95% CI 0.3-0.9, P = .009). Prevalence of HTN was 15% overall and among survivors 11-17 years and 18-39 years old, the prevalence was 10% and 14% or triple and double that of the general U.S. population, respectively. Pediatric HCT survivors are more likely to develop HTN than the general population and should be monitored for HTN throughout adulthood.
Control of Bragg grating resonant wavelength through its dependence on the effective index of a waveguide (1997)

Fabrication tolerances for control of the Bragg wavelength of gratings in waveguides are studied. Techniques are demonstrated to hold the period of the grating constant to /spl plusmn/0.04 nm over the majority of the exposed wafer area, and ridge waveguides fabricated with standard thin film process equipment are found to have Bragg wavelengths constant to within /spl plusmn/0.2 nm. Additionally, adjacent ridges with differing widths are written in a single photomask/etch process step and found to controllably shift the Bragg wavelength over a 10-20-nm band suitable for a distributed Bragg reflector (DBR) laser array or a monolithic comb filter for wavelength division multiplexing (WDM) filtering/routing arrays.
Adiponectin and Ghrelin Levels and Body Size in Normoglycemic Filipino, African‐American, and White Women (2007)

Normoglycemic Filipino and African-American women had significantly lower adiponectin concentrations than white women, and Filipinas had lower ghrelin levels than African-Americans, independently of body size or indices of insulin resistance or lipids.
Quantitative computed tomography–derived clusters: Redefining airway remodeling in asthmatic patients (2013)

Quantitative CT analysis provides a new perspective in asthma phenotyping, which might prove useful in patient selection for novel therapies.
Self-Assembly Mediated by the Donor−Donor−Acceptor·Acceptor−Acceptor−Donor (DDA·AAD) Hydrogen-Bonding Motif:  Formation of a Robust Hexameric Aggregate (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSelf-Assembly Mediated by the Donor−Donor−Acceptor·Acceptor−Acceptor−Donor (DDA·AAD) Hydrogen-Bonding Motif: Formation of a Robust Hexameric AggregateSergei V. Kolotuchin and Steven C. ZimmermanView Author Information Department of Chemistry, 600 South Mathews Ave. University of Illinois, Urbana, Illinois 61801 Cite this: J. Am. Chem. Soc. 1998, 120, 35, 9092–9093Publication Date (Web):August 21, 1998Publication History Received28 May 1998Published online21 August 1998Published inissue 1 September 1998https://pubs.acs.org/doi/10.1021/ja981862rhttps://doi.org/10.1021/ja981862rrapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1218Altmetric-Citations108LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Hydrocarbons,Noncovalent interactions,Size exclusion chromatography,Solvents Get e-Alerts
Mutational Analysis of Stem-Loops in the RNA Packaging Signal of the Moloney Murine Leukemia Virus (1998)

The retroviral RNA genome is targeted for incorporation into the nascent virion particle by the psi region, a specific block of RNA sequences near the 5' end. A number of deletions and linker insertion mutations were introduced into the psi region of cloned DNA of the Moloney murine leukemia virus, and the mutants were introduced into cells in culture and tested for their ability to direct the assembly of virions and the packaging of viral RNA. Only a small portion of the psi region was important for packaging, containing the so-called stem-loops C and D. Additional mutants were used to demonstrate that the base pairing of stem D, and the sequence of loop D, were essential for normal packaging of the RNA. Two mutants with alterations near the 5' splice donor were also replication-defective, probably due to effects on gene expression. The results allow a high-resolution definition of the RNA structures required during virus replication in culture.
Privacy Preserving Pattern Discovery in Distributed Time Series (2007)

The search for unknown frequent pattern is one of the core activities in many time series data mining processes. In this paper we present an extension of the pattern discovery problem in two directions. First, we assume data to be distributed among various participating peers, and require overhead communication to be minimized. Second, we allow the participating peer to be malicious, which means that we have to address privacy issues. We present three problems along with algorithms to solve them. They are presented in increasing order of complexity according to the extensions we are pursuing, i.e. distribution and privacy constraints. As the main result we present our secure multiparty protocol for the privacy preserving pattern discovery problem.
Spinal cord injury‐induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down‐regulation of the chloride transporter KCC2 in rat (2008)

Most spinal cord injury (SCI) patients suffer from chronic pain. Effective therapy for this pain is lacking, and the underlying mechanisms are poorly understood. The spinal superficial dorsal horn (SDH) contains neuronal circuits capable of modulating primary afferent information involved in pain processing. KCC2 is an isoform of the K(+)-Cl(-) cotransporter that contributes to the regulation of transmembrane anion gradient which plays a key role in shaping GABA(A) receptor-mediated signalling in the CNS. We tested the hypothesis that SCI causes down-regulation of KCC2 distal to the injury and contributes to the neuronal hyperresponsiveness and pain-related behaviours. SCI was a hemisection at T(13) level of adult Sprague-Dawley rats. Spinal sagittal slices with attached dorsal roots (DR) were prepared from L(4) to L(6) level. The reversal potentials of GABA responses (E(GABA)) and DR-evoked IPSPs and EPSPs of L(4-6) SDH neurones in sham-operated and SCI rats were compared using gramicidin-perforated patch-clamp recordings. Here we report that thoracic SCI-induced down-regulation of KCC2 in the lumbar SDH parallels the development of allodynia. The subsequent changes of E(GABA) in SDH neurones attenuate the GABA(A) receptor-mediated inhibitory synaptic transmission. These changes cause certain normally subthreshold primary A and C fibre inputs to evoke action potential output in SDH neurones. We conclude that SCI induces KCC2 down-regulation and subsequent changes of E(GABA) in the SDH below the injury site. The resulting disinhibition unmasks normally ineffective SDH neuronal circuits and may contribute to the below-level central pain-related behaviours after incomplete SCI.
Synthesis, Characterization And Antitumor Activity OfCopper(II) Complexes, [CuL<sub>2</sub>] [HL<sup>1-3</sup>=N,N‐Diethyl‐N′‐(R‐Benzoyl)Thiourea (R=H, o‐Cl and p‐NO<sub>2</sub>)] (2005)

The copper (II) complexes (CuL(2)) were prepared by reaction of Cu(CH(3)COO)(2) with the corresponding derivatives of acylthioureas in a Cu:HL molar ratio of 1:2. Acylthiourea ligands, N,N-diethyl-N'-(R-benzoyl) thiourea (HL(1-3)) [R=H, o-Cl and p-NO(2)] were synthesized in high yield (78-83%) and characterized by elemental analysis, infrared spectroscopy, (1)H and (13)C NMR spectroscopy. The complexes CuL(2) were characterized by elemental analysis, IR, FAB(+)-MS, magnetic susceptibility measurements, EPR and cyclic voltammetry. The crystal structure of the complex Cu(L(2))(2) shows a nearly square-planar geometry with two deprotonated ligands (L) coordinated to Cu(II) through the oxygen and sulfur atoms in a cis arrangement. The antitumor activity of the copper(II) complexes with acylthiourea ligands was evaluated in vitro against the mouse mammary adenocarcinoma TA3 cell line. These complexes exhibited much higher cytotoxic activity (IC(50) values in the range of 3.9-6.9 muM) than their corresponding ligands (40-240 muM), which indicates that the coordination of the chelate ligands around the Cu(II) enhances the antitumor activity and, furthermore, this result confirmed that the participation of the nitro and chloro substituent groups in the complex activities is slightly relevant. The high accumulation of the complexes Cu(L(2))(2) and Cu(L(3))(2) in TA3 tumor cells and the much faster binding to cellular DNA than Cu(L(1))(2) are consistent with the in vitro cytotoxic activities found for these copper complexes.
New genera and species of parasitic mites of the superfamily Parasitoidea (1933)

Parasitic mites of the superfamily Parasitoidea have long been recognized as of economic importance. In fact, one species, the common chicken mite, Dermanyssus gallinae, was studied and described by Redi in the seventeenth century. That these mites may be agents in the transmission of disease was demonstrated some years ago in the case of the common rat mite, E'chinolaelaps echidninus (Berlese), which was shown to transmit a disease-producing protozoan among white rats. Recently another species, the tropical rat mite, Liponyssus bacoti (Hirst), has been implicated in the transmission of a disease of man, endemic typhus. A study of the 15 species described as new in this paper has thrown much new light on generic characters in the group; in fact, it has PROCEEDINGS OF THE NATIONAL MUSEUM VOL. 82 rounded in front and with three setae, the front two of which are paired. Legs rather short; second pair stouter than the others. Coxae II with a pair of spines; other coxae without spines. Type species-Acanthochela chilensis, new species. Remarks.-Difters from Haemogamasus Berlese in having several recurved, fanglke setae on the fixed arm of the chelicerae and from Huhaemogamasus, described as new in this paper, in having many setae on the sternal plate. ACANTHOCHELA CHILENSIS, new species PuLate 1, Figure 1 Body about twice as long as wide and well provided with short setae. Palpi extending forward to tips of first patellae. Chelicerae moderate, fixed chela of each somewhat swollen toward the apex and bearing four recurved, thornlike setae. Sternal plate as broad as long, front corners produced, acuminate, with two pairs of pore slits and about 16 setae arranged more or less in pairs.
Hereditary Hemolytic Anemia with Increased Red Cell Adenosine Deaminase (45- to 70-fold) and Decreased Adenosine Triphosphate (1977)

Hereditary hemolytic anemia, a dominantly transmitted disorder, has affected 12 family members spanning three generations. The concentration of adenosine triphosphate in the red cells was about half that of comparably reticulocyte-rich blood. Since adenosine deaminase and adenosine kinase compete for a common substrate, the greatly increased activity of the former may interfere with nucleotide salvage via the latter.
CP DDT detonators. III. Powder column effects (1984)

In this investigation, we have examined the effects of powder column parameters on transition to detonation behavior in CP detonators. Increasing powder loading pressure increases bulk powder density, decreases void volume, and leads toward inhibition of DDT. The extent of inhibition, however, is affected by initial particle size, not simply bulk powder density. This implies that inhibition does not simply correlate with void volume. It has been shown that individual CP crystals undergo considerable diminution during loading. Virtually all porosity remains open; however, as loading pressure increases, the largest pores are eliminated. Transition to detonation in such detonators appears to correlate with gas permeability of the column and the existence of pores greater than approx. 0.2 ..mu..m. The results imply that CP DDT is controlled by gas flow through a small percentage of the total pores present and a small percentage of the total pore volume.
A functional MOS transistor featuring gate-level weighted sum and threshold operations (1992)

A functional MOS transistor is proposed which works more intelligently than a mere switching device. The functional transistor calculates the weighted sum of all input signals at the gate level, and controls the 'on' and 'off' of the transistor based on the result of such a weighted sum operation. Since the function is quite analogous to that of biological neurons, the device is named a neuron MOSFET, or neuMOS (vMOS). The device is composed of a floating gate and multiples of input gates that capacitively interact with the floating gate. As the gate-level sum operation is performed in a voltage mode utilizing the capacitive coupling effect, essentially no power dissipation occurs in the calculation, making the device ideal for ULSI implementation. The basic characteristics of neuron MOSFETs as well as of simple circuit blocks are analyzed based on a simple transistor model and experiments. Making use of its very powerful function, a number of interesting circuit applications are explored. A soft hardware logic circuit implemented by neuMOS transistors is also proposed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ViDE: A Vision-Based Approach for Deep Web Data Extraction (2009)

Deep Web contents are accessed by queries submitted to Web databases and the returned data records are enwrapped in dynamically generated Web pages (they will be called deep Web pages in this paper). Extracting structured data from deep Web pages is a challenging problem due to the underlying intricate structures of such pages. Until now, a large number of techniques have been proposed to address this problem, but all of them have inherent limitations because they are Web-page-programming-language-dependent. As the popular two-dimensional media, the contents on Web pages are always displayed regularly for users to browse. This motivates us to seek a different way for deep Web data extraction to overcome the limitations of previous works by utilizing some interesting common visual features on the deep Web pages. In this paper, a novel vision-based approach that is Web-page-programming-language-independent is proposed. This approach primarily utilizes the visual features on the deep Web pages to implement deep Web data extraction, including data record extraction and data item extraction. We also propose a new evaluation measure revision to capture the amount of human effort needed to produce perfect extraction. Our experiments on a large set of Web databases show that the proposed vision-based approach is highly effective for deep Web data extraction.
Expression of alkaline phosphatase loci in mammalian tissues (1980)

Alkaline phosphatases [orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1] have been examined in liver, bone, kidney, intestine, and placenta from nine mammalian species by quantitative inhibition and thermostability studies and compared with alkaline phosphatases in the corresponding human tissues. In humans, three kinds of alkaline phosphatase can be sharply differentiated by these methods, one occurring in liver, bone, and kidney, one in intestine, and one in placenta. They are evidently determined by separate gene loci. In the mammals only two sorts of alkaline phosphatase were found: one, which occurs in liver, bone, kidney, and also placenta, corresponds to the human liver/bone/kidney enzyme and the other corresponds to the human intestinal enzyme. The findings support our earlier proposal that the expression of a distinctive type of alkaline phosphatase in human placenta is the consequence of a late evolutionary event which occurred subsequent to the divergence of the evolutionary lineage leading to humans from the various lineages leading to other mammalian species. The concentrations of the inhibitors, phenylalanine, homoarginine, phenylalanylglycylglycine, and levamisole, required to give 50% inhibition, [I(50)], of the liver/bone/kidney/placental (nonhuman) alkaline phosphatases showed no significant variation among the species. However, the [I(50)] values for the intestinal enzyme varied among species to a much greater extent. This implies that in the liver/bone/kidney/placental (nonhuman) alkaline phosphatase the structures of the binding sites for these inhibitors have been highly conserved during mammalian evolution, but there has been much greater divergence of these structures in the evolution of intestinal alkaline phosphatases.
Quasi-Analytical method for estimating low false alarm rate (2010)

This paper proposes a new approach for estimating low false alarm rate (FAR) using Quasi-Analytical (QA) method. The results from both theoretical analysis and simulation show that QA estimation is unbiased with obvious simulation speed improvement with respect to Monte Carlo (MC) and Conventional Importance Sampling (IS) for typical application cases. Furthermore, unlike IS approaches that rely on complex optimization procedures for optimal IS parameters or sub optimal parameters, the QA is simple to implement and computationally effective.