gebhart/patrepeval huggingface dataset:
Resonant-tunneling-diode loads: speed limits and applications in fast logic circuits (2003)

It is shown that the high-speed and negative-resistance properties of the resonant tunneling diode (RTD) can improve the performance of some common inverters by greatly reducing the static power dissipation while affecting the dynamic properties to a much lesser extent. InGaAs RTDs with a peak-to-valley ratio of 12 at room temperature can switch in approximately 2 ps and, therefore, are useful as negative resistance loads for heterostructure transistors in digital circuits HFET-RTD and HBT-RTD inverter have been simulated using SPICE. The switching of the 1.0 mu m-gate-length HFT-RTD inverter is greater than that of the E-D HFET (heterostructure FET) inverter by over a factor of two, and static power is lower by a factor of five. A similar contrast is found between HBT-RTD and conventional HBT-I/sup 2/L (integrated injection logic) inverters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
On the dynamics of the human brain in temporal lobe epilepsy. (1991)

Epileptic seizures reflect a pathological state of brain electrical activity, which may occur spontaneously as a result of functional neuronal disturbances in the cerebral cortex. Investigation of the epileptic human brain as a nonlinear system, that undergoes a phase transition (seizure), is the topic of this study. The existence of limit cycles during the ictal state (seizure), characteristic of nonlinear systems, was shown by modeling data recorded by subdural chronically implanted electrodes (ECoG). Theoretical measures of complexity ($\nu$) and chaoticity (L) of a steady state and their relation to the Shannon entropy rate were derived. Methods for the estimation of the aforementioned measures were developed and applied to simulation examples from the literature and experimental data from various seizures of epileptic patients. The required phase space of the system, for the estimation of $\nu$ and L, was reconstructed by the method of delays. The estimated values of the phase correlation dimension $\nu$ indicate that the epileptic brain possesses fewer degrees of freedom ictally (2 $\sim$ 3) than preictally or postictally (5 $\sim$ 10). This trend is in agreement with the fitting of the data with linear and nonlinear autoregressive models. The estimated mean values of the largest Lyapunov exponent L over time indicate a more chaotic state postictally than ictally or preictally. The start of a seizure corresponds to a simultaneous drop in the values of L at the focal electrode sites. The slow cyclic variations, that are observed in the temporal Lyapunov profiles, imply attempts of the system to undergo a phase transition minutes before the seizure's onset. The analysis of the rate of entropy production over space revealed, preictally, an initial phase difference of minutes for the sites overlying the seizure focus, which progressed to phase locking, with a slow entrainment of the rest of the cortical sites shortly before the onset of the seizure. The above results suggest that localization and prediction of an impending seizure may be possible up to 10 minutes before the actual event. Also, this study suggests a model for the generation of a focal epileptic seizure.
Partitioning MOF-5 into Confined and Hydrophobic Compartments for Carbon Capture under Humid Conditions (2016)

Metal-organic frameworks (MOFs), by virtue of their remarkable uptake capability, selectivity, and ease of regeneration, hold great promise for carbon capture from fossil fuel combustion. However, their stability toward moisture together with the competitive adsorption of water against CO2 drastically dampens their capacity and selectivity under real humid flue gas conditions. In this work, an effective strategy was developed to tackle the above obstacles by partitioning the channels of MOFs into confined, hydrophobic compartments by in situ polymerization of aromatic acetylenes. Specifically, polynaphthylene was formed via a radical reaction inside the channels of MOF-5 and served as partitions without altering the underlying structure of the framework. Compared with pristine MOF-5, the resultant material (PN@MOF-5) exhibits a doubled CO2 capacity (78 vs 38 cm(3)/g at 273 K and 1 bar), 23 times higher CO2/N2 selectivity (212 vs 9), and significantly improved moisture stability. The dynamic CO2 adsorption capacity can be largely maintained (>90%) under humid conditions during cycles. This strategy can be applied to other MOF materials and may shed light on the design of new MOF-polymer materials with tunable pore sizes and environments to promote their practical applications.
A Heterogeneous Feature-based Image Alignment Method (2006)

In this paper, we propose a robust heterogeneous feature based image alignment method that utilizes points, lines and regions in a unified framework. The image motion is decomposed into progressively complex components, i.e., translation, similarity, affine, and projective motion models, and alignment is obtained with deliberatively selected suitable feature types and associated descriptors. Large convergence range is obtained by gradually constraining the search range of features in each stage. Notably, point and line features are jointly used and formulated in a RANSAC (Random Sample Consensus) framework for robust estimation of a homography between low textured images. Further improvement is obtained with region based direct method. Experiments demonstrate superior alignment results of our approach to both gradient-based direct method and tradition point feature based alignment method.
Boron-nitride nanotube triggered self-assembly of hexagonal boron-nitride nanostructure (2014)

Molecular mechanics results show that a hexagonal boron nitride (h-BN) membrane can spontaneously assemble on the single-walled boron nitride nanotube (BNNT) in a scroll or helical manner, showing an interesting dependence on h-BN width. The size of BNNTs should meet the required conditions to guarantee self-assembly. Further analyses of energy components and structural geometry show that this unique phenomenon is because of the combined action of van der Waals interactions and the π-π stacking effect. The h-BNs with arbitrary sizes and shapes can wrap onto BNNTs to form various configurations. The self-assembly conditions and the stability of the formed nanoconfigurations are investigated for numerous potential applications.
Abstract 3720: Intrinsic and acquired resistance mechanisms of alectinib in ALK rearranged cells (2014)

Abstract Background However potency of Alectinib, a selective ALK inhibitor, for ALK rearranged NSCLC and for that with secondary mutation have been reported, intrinsic and acquired resistance are likely to emerge. Recent study showed tumor microenvironment triggered resistance to Crizotinib and TAE684. In this study, we examine whether emerging of intrinsic and acquired resistance are affected by tumor microenvironment in H3122, EML4-ALK positive lung cancer cell line, and in Alectinib-resistant clone of H3122 (AFR) which is generated in vitro. Elucidating intrinsic resistant mechanisms and preceding development of acquired resistance to understand its mechanisms will provide beneficial information for the development of novel therapeutic strategies in clinical practice. Methods We examined the effect of EGF produced by endothelial cells on Alectinib sensitivity of H3122 cell line, and EGF and HGF produced by fibroblasts on Alectinib sensitivity of H3122AFR by clonogenic assay. Downstream pathways of ALK in both cells were analyzed by western blotting. Combination treatments of Alectinib and other TKI were tested both in vitro and in vivo. Results H3122 cells which had been cultured with EGF acquired resistance to Alectinib treatment. Combination treatment of Alectinib and Erlotinib overcome EGF induced resistance and showed down-regulation in phosphorylation of AKT and ERK1/2. H3122AFR cells were also reduced their sensitivity to Alectinib at 100 uM or higher concentration when the media contained EGF or HGF. Erlotinib or Crizotinib combined with Alectinib canceled the EGF-induced or HGF-induced resistance by down-regulating phosphorylation of AKT and ERK1/2. In vivo, tumor xenografts of nude mice which had been orally administered Alectinib and Erlotinib showed tumor regression in both H3122 and H3122AFR, and those received Alectinib and Crizotinib showed regression in H3122AFR. Conclusion In our study, we showed ligands produced by tumor microenvironment, such as EGF and HGF, contributed the emerging of intrinsic resistance and acquired resistance by activating survival pathway. Further, the efficacy of combination treatment of Alectinib with Erlotinib or that with Crizotinib was shown. Collectively, Alectinib combined with EGFR-TKI would be an effective strategy for Alectinib-resistant lung cancer, and Alectinib with crizotinib is another considerable strategy. Citation Format: Yukiko Hibino, Sasaki Takaaki, Yoshinori Minami, Pasi A. Janne, Yoshinobu Ohsaki. Intrinsic and acquired resistance mechanisms of alectinib in ALK rearranged cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3720. doi:10.1158/1538-7445.AM2014-3720
Retrieval of spatio-temporal sequence in asynchronous neural network (1990)

We develop an argument that a neural network with asynchronous updating dynamics is capable of sequential retrieval of properly embedded spatial patterns. It is not necessary that the patterns be random, but they have to satisfy certain restrictions. The network is a generalization of the Hopfield model with a specific type of asymmetric synaptic connections. No time delay is introduced in signal transmission, in contrast to some of the recently proposed networks.
ChemInform Abstract: anti‐Selective Catalytic Asymmetric Nitroaldol Reaction via a Heterobimetallic Heterogeneous Catalyst. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 <sup>WAF1/CIP1</sup> Mediated by STAT1 (1996)

Signal transducers and activators of transcription (STAT) proteins can be conditionally activated in response to epidermal growth factor (EGF) and interferon (IFN)-gamma. STAT activation was correlated with cell growth inhibition in response to EGF and IFN-gamma. Activated STAT proteins specifically recognized the conserved STAT-responsive elements in the promoter of the gene encoding the cyclin-dependent kinase (CDK) inhibitor p21 WAF1/CIP1 and regulated the induction of p21 messenger RNA. IFN-gamma did not inhibit the growth of U3A cells, which are deficient in STAT1, but did inhibit the growth of U3A cells into which STAT1 alpha was reintroduced. Thus, STAT1 protein is essential for cell growth suppression in response to IFN-gamma. The STAT signaling pathway appears to negatively regulate the cell cycle by inducing CDK inhibitors in response to cytokines.
Active Filters for UHF and Microwave Frequencies (1969)

A technique is described for using transistors directly as high-Q inductors at microwave frequencies. Several experimental band-pass filters have been built and tested to verify usefulness of the inductive transistor circuit. Stable filters with unity insertion loss have been realized at UHF. Observations made during temperature cycling show that environmental stabilization can also be achieved. Analysis has been made of noise figure and nonlinear distortion, and supporting experimental data are provided. The inductive transistor circuit is expected to be practical for a variety of small-signal filtering and multiplexing applications.
Semibatch emulsion polymerization of butyl acrylate. II. Effects of emulsifier distribution (2000)

The effects of emulsifier distribution ratio between the initial charge and the feed on particle formation and kinetics of butyl acrylate emulsion polymerization, using sodium lauryl sulfate as emulsifier and potassium persulfate as initiator, were investigated. The number of particles increased with initial emulsifier concentration in the reactor charge. It was shown that traditional ranking, in terms of number of particles produced, of semibatch emulsion polymerization with monomer emulsion feed is not always justified and a semibatch emulsion polymerization can produce far more particles than a conventional batch emulsion polymerization. The number of polymer particles was found to be practically independent of the emulsifier distribution ratio between the charge and the feed for a high overall emulsifier concentration, while for a low overall emulsifier concentration, the number of particles increased with initial loading of the emulsifier. The polydispersity index (PDI) of the final latexes showed a minimum with emulsifier distribution. A bimodal particle size distribution, and a latex with a large PDI, was obtained when there was no emulsifier in the charge. As the initial emulsifier charge increased, a unimodal PSD with a smaller PDI was obtained. With higher proportions of emulsifier in the initial charge, the PDI rose again due to particle nucleation at monomer-starved conditions, and a skewed unimodal PSD was obtained. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 79: 582–597, 2001
Introduction (2007)

The purpose of this book is to remedy the central weakness in Coleridge studies: the persistent failure to grasp the full significance of the pantheism controversy for Coleridge's poetry and thought. Thomas McFarland's (1969) Coleridge and the Pantheist Tradition—considered authoritative for almost 40 years now—has indirectly contributed to this problem because it articulates a very specific and idiosyncratic understanding of the issue, and its 'authoritative' status has denied it meaningful engagement in the literature. The result is that some of the most important and abiding aspects of Coleridge's intellectual development have been left drastically under-examined, as McFarland's book made the question seem exhausted. This book overturns McFarland's understanding of key philosophical aspects of the pantheism controversy, and Coleridge's understanding of the controversy.KeywordsPrior ConceptionHermeneutic CircleGerman IdealismHermeneutic ApproachReligious PietyThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Automatic replay generation for soccer video broadcasting (2004)

While most current approaches for sports video analysis are based on broadcast video, in this paper, we present a novel approach for highlight detection and automatic replay generation for soccer videos taken by the main camera. This research is important as current soccer highlight detection and replay generation from a live game is a labor-intensive process. A robust multi-level, multi-model event detection framework is proposed to detect the event and event boundaries from the video taken by the main camera. This framework explores the possible analysis cues, using a mid-level representation to bridge the gap between low-level features and high-level events. The event detection results and mid-level representation are used to generate replays which are automatically inserted into the video. Experimental results are promising and found to be comparable with those generated by broadcast professionals.
Natural Products in Combinatorial Chemistry:  An Andrographolide-Based Library (2006)

The generation of a natural-product-based library starting from andrographolide is described. Utilizing andrographolide itself in parallel solution-phase synthesis leads to a 360-membered library. The initial transformation of the starting material via ozonolysis is followed by the conversion into a suitable template by introduction of a thiazole moiety. Subsequent decoration at two points of diversity yields the desired natural product derivatives. The selection of actually synthesized compounds is based on a virtually generated library and the assessment of its members with respect to physicochemical parameters, thus ensuring pharmacological relevance of the compounds.
Comparison of Results from a Phase 1/2 Study of Lumiliximab (Anti-CD23) in Combination with FCR for Patients with Relapsed CLL with Published FCR Results. (2006)

Abstract Lumiliximab is a PRIMATIZED® anti-CD23 monoclonal antibody with human IgG1 constant regions and macaque variable regions. Preclinical data demonstrated that lumiliximab enhanced both fludarabine- and rituximab- mediated apoptosis in CLL cells. Thus, a Phase 1/2, open-label, dose-escalation, multicenter study (Study 152–30) evaluating lumiliximab + fludarabine, cyclophosphamide, and rituximab (L + FCR) for relapsed CD23+ B-cell CLL was initiated. Treatment has been completed and follow-up is ongoing. Thirty-one patients (pts) received either 375 mg/m2 (n=3) or 500 mg/m2 (n=28) of lumiliximab in combination with a 28-day cycle of FCR for up to 6 cycles. Median age at study entry was 58 yrs. The majority of pts (74%) were Rai Stage I/II. The most common adverse events included nausea (77%), pyrexia (61%), chills (55%), neutropenia (55%), and fatigue (48%). Twenty pts (65%) experienced a Grade 3 or 4 event. An overall response rate of 71% was demonstrated: 48% complete response (CR), 10% partial response (PR), and 13% unconfirmed PR. Currently, baseline cytogenetic data is available for 21 pts who received 500 mg/m2 of lumiliximab. Although preliminary, 1 of the 4 pts with del(17p13.1) responded; of the 6 pts with del(11q22.3), 5 responded with 4 attaining a CR. A comparison with published data from a study of FCR alone in 177 pts with relapsed or refractory CLL conducted at the M.D. Anderson Cancer Center (MDACC) (Wierda W, O’Brien S, Wen S, et al. J Clin Oncol.2005;23:4070–4078) demonstrated that L + FCR has an acceptable safety profile, does not appear to increase the toxicity (including myelosuppression) of the FCR regimen, and compares favorably with the CR rate of the FCR regimen alone, as displayed in Table 1. Most pt characteristics (age, gender, median number of prior therapies, and WHO performance status) were similar between the 2 studies; however, more pts in the MDACC study were Rai Stage III-IV (50% vs 22%) and were rituximab-naïve (88% vs 40%). Furthermore, there were no obvious differences in hematologic toxicity between the 2 studies and the tolerability of L + FCR was similar to that of FCR, with approximately 50% percent of pts completing 6 cycles of treatment in both studies. These data suggest that L + FCR may produce a higher complete response rate than FCR without additional toxicity. Based upon this data, a multicenter, global, randomized study of L + FCR vs. FCR alone is being initiated. Table 1. Comparison of Responses in Study 152–30 and the MDACC Study Study 152–30, L + FCR (N=31), n (%) MDACC, FCR (N =177), n (%) 1CR and PR response criteria were the same in both studies. 2PRu is included in the OR. Overall Response 22 (71%) 130 (73%) Complete Response1 15 (48%) 45 (25%) Partial Response1 3 (10%) 85 (48%) Unconfirmed Partial Response2 4 (13%)
Silhouette and stereo fusion for 3D object modeling (2004)

We present a new approach to high quality 3D object reconstruction. Starting from a calibrated sequence of color images, the algorithm is able to reconstruct both the 3D geometry and the texture. The core of the method is based on a deformable model, which defines the framework where texture and silhouette information can be fused. This is achieved by defining two external forces based on the images: a texture driven force and a silhouette driven force. The texture force is computed in two steps: a multistereo correlation voting approach and a gradient vector flow diffusion. Due to the high resolution of the voting approach, a multigrid version of the gradient vector flow has been developed. Concerning the silhouette force, a new formulation of the silhouette constraint is derived. It provides a robust way to integrate the silhouettes in the evolution algorithm. As a consequence, we are able to recover the apparent contours of the model at the end of the iteration process. Finally, a texture map is computed from the original images for the reconstructed 3D model.
Low Molecular Weight Activated Protein C Inhibitors as a Potential Treatment for Hemophilic Disorders (2006)

The synthesis and evaluation of inhibitors of activated protein C (aPC) are reported. This serine protease is partly responsible for the degradation of factor VIIIa, involved in the regulation of bleeding in hemophilia A. Benzamidine-containing derivatives were found to be potent aPC inhibitors, some of them showing selectivity against the procoagulant protease thrombin. Moreover, compound 1 significantly restored the generation of thrombin in hemophiliac plasma.
Identification of feline- and canine-like rotaviruses isolated from humans by restriction fragment length polymorphism assay (1993)

Restriction fragment length polymorphism assay of reverse-transcribed and polymerase chain reaction-amplified rotavirus gene segment 9 was developed to differentiate human serotype 3 rotaviruses from animal serotype 3 rotaviruses. On the basis of similarities or differences in HinfI and DdeI restriction profiles, unusual group A serotype 3 human rotaviruses that belonged to subgroup I were shown to be of feline and canine origin. By this approach, the new human rotavirus isolates 5193, AU-387, AU-720, AU-785 and AU-1115 were shown to resemble certain feline-like human rotaviruses. Similar results were previously obtained by Nakagomi et al. (O. Nakagomi, A. Hoshima, Y. Aboudy, I. Shif, M. Mochizuki, T. Nakagomi, and T. Gotlieb-Stematsky. J. Clin. Microbiol. 28:1198-1203, 1990) by using RNA-RNA cross hybridization with established feline rotaviruses. The restriction fragment length polymorphism assay can provide fast and valuable information on the interspecies transmission of rotaviruses in nature.
Fast Quadratic Phase Transform for Estimating the Parameters of Multicomponent Chirp Signals (1997)

We present a technique based on the quadratic phase transform (QPT) for joint phase parameter estimation of multicomponent chirp signals. The QPT has the ability to analyze chirp signals in the same way as Fourier transform analyzes sinusoidal signals. In view of its practical implementation, a discrete version of the QPT, called the discrete quadratic phase transform (DQPT), is introduced. A novel fast computational procedure of the DQPT is developed. Explicit expressions for the arithmetic operation count are derived. Simulation results are presented to illustrate the usefulness of the DQPT.