gebhart/patrepeval huggingface dataset:
The Effect of Porcine Relaxin Vaginally Applied at Human Embryo Transfer in an In Vitro Fertilization Programme (1985)

It has been suggested that the polypeptide hormone relaxin is an early pregnancy factor which facilitates implantation and pregnancy maintenance. To test this hypothesis a double blind randomized placebo controlled trial was conducted where 2 mg purified porcine relaxin or distilled water was given in a vaginal gel on the day of embryo transfer and again 3 days later in a human in vitro fertilization (IVF) programme. There were 96 patients in the randomized trial and 73 patients who were treated concurrently in the same IVF programme acted as a further control group. Of the 51 patients who received relaxin, 10 pregnancies were confirmed and 8 continued successfully. In the 45 patients treated with placebo 10 pregnancies were also confirmed and 6 continued successfully. Amongst the 73 patients concurrently treated outside the trial 14 achieved a pregnancy and 10 continued to term. Thus, porcine relaxin given in these circumstances in a human IVF programme did not appear to improve or interfere with the pregnancy rate. Possible factors that affected the implantation rates in this trial are discussed.
Structure-based Engineering of Species Selectivity in the Interaction between Urokinase and Its Receptor (2010)

The high affinity interaction between the urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) is decisive for cell surface-associated plasminogen activation. Because plasmin activity controls fibrinolysis in a variety of pathological conditions, including cancer and wound healing, several intervention studies have focused on targeting the uPA.uPAR interaction in vivo. Evaluations of such studies in xenotransplanted tumor models are, however, complicated by the pronounced species selectivity in this interaction. We now report the molecular basis underlying this difference by solving the crystal structure for the murine uPA.uPAR complex and demonstrate by extensive surface plasmon resonance studies that the kinetic rate constants for this interaction can be swapped completely between these orthologs by exchanging only two residues. This study not only discloses the structural basis required for a successful rational design of the species selectivity in the uPA.uPAR interaction, which is highly relevant for functional studies in mouse models, but it also suggests the possible development of general inhibitors that will target the uPA.uPAR interaction across species barriers.
Multiplex fiber-optic biosensor using multiple particle plasmon resonances (2011)

Multiplex fiber-optic biosensor implemented by integrating multiple particle plasmon resonances (PPRs), molecular bioassays, and microfluidics is successfully demonstrated. The multiple PPRs are achieved by chemical immobilization of silver nanoparticles (AgNPs) and gold nanorods (AuNRs) separately on two unclad portions of an optical fiber. The difference in morphology and nature of material of AgNPs and AuNRs are exploited to yield multiple plasmonic absorptions at 405 and 780 nm in the absorption spectrum measured from optical fiber by white light source illumination. Through the coaxial excitation of light-emitting diodes (LEDs) with 405 and 800 nm wavelengths, the distinct PPRs are advantageous for real-time and simultaneous detection of multiple analyte-probe pairs as AgNPs and AuNRs are separately functionalized with specific bio-probes. Here, the multi-window fiber-optic particle plasmon resonance (FO-PPR) biosensor has been shown to be capable of simultaneously detecting anti-dinitrophenyl antibody (anti-DNP, MW = 220 kDa) via N-(2,4-dinitrophenyl)-6-aminohexanoic acid (DNP, MW = 297.27 Da) functionalized AgNPs and streptavidin (MW = 75 kDa) via N-(3-aminopropyl)biotinamide trifluoroacetate (biotin, MW = 414.44 Da) functionalized AuNRs. The multiplex sensing chip possesses several advantages, including rapid and parallel detection of multiple analytes on a single chip, minimized sample to sample variation, reduced amount of sensor chip, and reduced analyte volume, hence it is ideally suitable for high-throughput multiplex biochemical sensing applications.
Clustering of Calcium Phosphate in the System CaCl<sub>2</sub>−H<sub>3</sub>PO<sub>4</sub>−KCl−H<sub>2</sub>O (1999)

The stability of calcium phosphate clusters approximately 0.8 nm in diameter, which were found in a simulated body fluid in a previous work, was investigated in the system CaCl2−H3PO4−KCl−H2O using an intensity-enhanced dynamic light-scattering technique at 25 °C. It was shown that tris(hydroxymethyl)aminomethane, which was used as a buffer in the previous study, had no effect on the formation of the clusters. The amount of clusters decreased with decreasing supersaturation of the solution with respect to hydroxyapatite. Under constant supersaturation with respect to hydroxyapatite, the amount of the clusters reached a maximum in solutions with Ca/P molar ratios ranging from 1 to 8.
Clonal analysis of the serogroup B meningococci causing New Zealand's epidemic (2005)

An epidemic of meningococcal disease caused by serogroup B meningococci expressing the P1.7-2,4 PorA protein began in New Zealand in 1991. The PorA type has remained stable. Different porB have been found in association with the P1.7-2,4 PorA, although type 4 has been most common. The clonal origins of B:P1.7-2,4 meningococci isolated from cases during 1990 to the end of 2003 were analysed. In 1990, the year immediately preceding the recognized increase in disease rates, all three subclones (ST-41, ST-42, and ST-154) of the ST-41/44 clonal complex occurred among the five isolates of B:P1.7-2,4. The two sequence types, ST-42 and ST-154, continued to cause most disease throughout New Zealand. Isolates belonging to subclone ST-41 were mostly identified early in the epidemic and in the South Island. 16S rRNA typing indicated that isolates belonging to the subclones ST-41 and ST-154 share a common ancestor, with those typing as ST-42 more distantly related with some genetically ambiguous. It is possible that ST-41 and ST-154 may have evolved one from the other but evolution to ST-42 is more difficult to explain. It is possible that one or more of the ST types could have been introduced into New Zealand prior to the first detection of clinical cases in 1990. Genetic diversity may have occurred during carriage in the community.
Intermediates in the reduction of N2 to NH3: synthesis of iron η2 hydrazido(1−) and diazene complexes (2009)

Iron complexes containing hydrazido(1-) and diazene ligands were investigated as potential intermediates in the reduction of N(2) to NH(3). Generation of cis-[Fe(DMeOPrPE)(2)(eta(2)-N(2)H(3))](+) and cis-Fe(DMeOPrPE)(2)(eta(2)-N(2)H(2)) (DMeOPrPE = 1,2-bis(dimethoxypropylphosphino)ethane) was achieved by addition of base to cis-[Fe(DMeOPrPE)(2)(N(2)H(4))](2+). The hydrazine, hydrazido(1-), and diazene complexes can be interconverted by protonation/deprotonation reactions.
Use of crospovidone as pelletization aid as alternative to microcrystalline cellulose: effects on pellet properties (2009)

Crospovidone shows an excellent behavior as pelletization aid and produces fast-releasing pellets even with low-soluble APIs.
Experimental validation and performance evaluation of OpenFlow-based wavelength path control in transparent optical networks (2011)

OpenFlow, as an open-source protocol for network virtualization, is also widely regarded as a promising control plane technique for heterogeneous networks. But the utilization of the OpenFlow protocol to control a wavelength switched optical network has not been investigated. In this paper, for the first time, we experimentally present a proof-of-concept demonstration of OpenFlow-based wavelength path control for lightpath provisioning in transparent optical networks. We propose two different approaches (sequential and delayed approaches) for lightpath setup and two different approaches (active and passive approaches) for lightpath release by using the OpenFlow protocol. The overall feasibility of these approaches is experimentally validated and the network performances are quantitatively evaluated. More importantly, all the proposed methodologies are demonstrated and evaluated on a real transparent optical network testbed with both OpenFlow-based control plane and data plane, which allows their feasibility and effectiveness to be verified, and valuable insights of the proposed solutions to be obtained for deploying into real OpenFlow controlled optical networks.
Cloning and expression of antigenic epitopes of the human 68-kDa (U1) ribonucleoprotein antigen in Escherichia coli. (1991)

Autoantibodies directed against the 68-kDa (U1) ribonucleoprotein antigen are mainly found in sera of patients with mixed connective tissue disease. The corresponding cDNA was fragmented into four regions coding for the major antigenic epitopes A', B', C' and D'. All the epitopes were subcloned and expressed as fusion proteins with the glutathione S-transferase in Escherichia coli using the novel expression system pGEX that allows very high yields of recombinant proteins after a single-step purification. The sera of patients with the autoimmune disease were analyzed for the expressed recombinant proteins by an immunoblotting technique. All positive sera showed a patient-specific behavior and could be divided into four groups regarding recognition of the four antigenic epitopes of the 68-kDa (U1) ribonucleoprotein antigen. The epitope B' was reactive to all patient sera positively tested and classified as the marker antigenic epitope for the mixed connective tissue disease.
Pitfalls in Ultralightweight Authentication Protocol Designs (2015)

This article introduces prudent engineering practices and offers recommendations to follow, together with typical mistakes to avoid, when designing new ultralightweight authentication protocols. This work can help, as a sanity check, designers of RFID, NFC, and sensor networks based security solutions to improve the security, reliability, and longevity of ultralightweight authentication protocol designs. Additionally, it aims to help reviewers to quickly distinguish what is really new and worthy in a research area that has been flooded lately with proposals of dubious quality.
Effects of Vehicle Interior Geometry and Anthropometric Variables on Automobile Driving Posture (2000)

The effects of vehicle package, seat, and anthropometric variables on posture were studied in a laboratory vehicle mockup. Participants (68 men and women) selected their preferred driving postures in 18 combinations of seat height, fore-aft steering wheel position, and seat cushion angle. Two seats differing in stiffness and seat back contour were used in testing. Driving postures were recorded using a sonic digitizer to measure the 3D locations of body landmarks. All test variables had significant independent effects on driving posture. Drivers were found to adapt to changes in the vehicle geometry primarily by changes in limb posture, whereas torso posture remained relatively constant. Stature accounts for most of the anthropometrically related variability in driving posture, and gender differences appear to be explained by body size variation. Large intersubject differences in torso posture, which are fairly stable across different seat and package conditions, are not closely related to standard anthropometric measures. The findings can be used to predict the effects of changes in vehicle and seat design on driving postures for populations with a wide range of anthropometric characteristics.
levo-2,3-Dinitroxybutane (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTlevo-2,3-DinitroxybutaneA. F. McKay, R. H. Meen, and George F WrightCite this: J. Am. Chem. Soc. 1948, 70, 1, 430Publication Date (Print):January 1, 1948Publication History Published online1 May 2002Published inissue 1 January 1948https://pubs.acs.org/doi/10.1021/ja01181a524https://doi.org/10.1021/ja01181a524research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DNA Microarrays: a Powerful Genomic Tool for Biomedical and Clinical Research (2007)

Among the many benefits of the Human Genome Project are new and powerful tools such as the genome-wide hybridization devices referred to as microarrays. Initially designed to measure gene transcriptional levels, microarray technologies are now used for comparing other genome features among individuals and their tissues and cells. Results provide valuable information on disease subcategories, disease prognosis, and treatment outcome. Likewise, they reveal differences in genetic makeup, regulatory mechanisms, and subtle variations and move us closer to the era of personalized medicine. To understand this powerful tool, its versatility, and how dramatically it is changing the molecular approach to biomedical and clinical research, this review describes the technology, its applications, a didactic step-by-step review of a typical microarray protocol, and a real experiment. Finally, it calls the attention of the medical community to the importance of integrating multidisciplinary teams to take advantage of this technology and its expanding applications that, in a slide, reveals our genetic inheritance and destiny.
1994 SIGAPL survey results (1995)

article Free Access Share on 1994 SIGAPL survey results Author: Dick Holt SIGAPL Member-at-Large, 3802 N. Richmond Street, Arlington, VA, USA SIGAPL Member-at-Large, 3802 N. Richmond Street, Arlington, VA, USAView Profile Authors Info & Claims ACM SIGAPL APL Quote QuadVolume 25Issue 3March 1995 pp 9–15https://doi.org/10.1145/202088.202089Online:01 March 1995Publication History 1citation96DownloadsMetricsTotal Citations1Total Downloads96Last 12 Months2Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Preparation and properties of some silyl- and germyl-halogenoacetylenes and of digermylacetylene (1978)

The compounds H3SiCCCl, D3SiCCCl, H3SiCCBr, H3GeCCCl, H3GeCCGeH3, and H3SiCCSiH3 have been prepared by reaction of silyl or germyl halides with the lithium and sodium derivatives Li(CCCl), Li2C2, and Na(CCBr). They have been characterised by a variety of physical and spectroscopic techniques (i.r., Raman, u.v., and photoelectron spectroscopy). Normal-co-ordinate analysis-of the vibrational data shows that most vibrations of these molecules are isolated, but that the two low-frequency stretches and the two skeletal bends are strongly coupled.
The Rare Earth Metals and their Compounds. XII. Carbonates of Lanthanum, Neodymium and Samarium (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Rare Earth Metals and their Compounds. XII. Carbonates of Lanthanum, Neodymium and SamariumMurrell L. Salutsky and Laurence L. QuillCite this: J. Am. Chem. Soc. 1950, 72, 7, 3306–3307Publication Date (Print):July 1, 1950Publication History Published online1 May 2002Published inissue 1 July 1950https://pubs.acs.org/doi/10.1021/ja01163a537https://doi.org/10.1021/ja01163a537research-articleACS PublicationsRequest reuse permissionsArticle Views358Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Long‐term outcomes with oral therapy in liver transplant recipients with hepatitis B (2019)

Tenofovir alafenamide appears to have less of an impact on renal function in LT recipients than other antiviral agents. HBV recurrence after transplant is associated with decreased patient survival and remains an important issue to address for LT recipients on oral antiviral therapy.
Electron Beam Excitation and Damage of Biological Molecules; Its Implications for Specimen Damage in Electron Microscopy (1973)

M. Isaacson, D. Johnson, A. V. Crewe, Electron Beam Excitation and Damage of Biological Molecules; Its Implications for Specimen Damage in Electron Microscopy, Radiation Research, Vol. 55, No. 2 (Aug., 1973), pp. 205-224
PAMAM Dendrimers as Potential Agents against Fibrillation of<i>α</i>‐Synuclein, a Parkinson's Disease‐Related Protein (2008)

The effect of PAMAM dendrimers (generations G3, G4 and G5) on the fibrillation of alpha-synuclein was examined by fluorescence and CD spectroscopy, TEM and SANS. PAMAM dendrimers inhibited fibrillation of alpha-synuclein and this effect increased both with generation number and PAMAM concentration. SANS showed structural changes in the formed aggregates of alpha-synuclein--from cylindrical to dense three-dimensional ones--as the PAMAM concentration increased, on account of the inhibitory effect. PAMAM also effectively promoted the breaking down of pre-existing fibrils of alpha-synuclein. In both processes--that is, inhibition and disassociation of fibrils--PAMAM redirected alpha-synuclein to an amorphous aggregation pathway.
Pedogenic and lithogenic contributions to the magnetic susceptibility record of the Chinese loess/palaeosol sequence (1995)

We have studied the magnetic properties of 69 loess and palaeosol samples from the loess plateau in China. Our methodology involves the combination of differential dissolution of secondary iron oxides and oxyhydroxides using citrate-bicarbonate-dithionite (CBD) with measurements of magnetic parameters. Because most of these parameters are additive, we can use pre- and post-CBD values to determine the mineral magnetic properties of the CBD-soluble material. We can also calculate the partitioning of iron among various phases. Approximately two-thirds of the total iron in our samples exists as paramagnetic iron in silicate minerals. Anti-ferromagnetic material (haematite) constitutes almost all of the remainder. However, the magnetic susceptibility record of the loess/palaeosol sequence arises primarily from a small amount of iron in ferrimagnetic phases. This iron consists of a CBD-resistant component which represents multidomain grains inherited from the parent material of the loess, and a CBD-soluble component which represents grains near the superparamagnetic/single domain boundary. The first component appears in nearly uniform amounts throughout the loess column and is the dominant ferrimagnetic phase in the magnetically less-enhanced loess. Accumulation of the second component in the palaeosols gives rise to the magnetic susceptibility enhancement of the loess column. The magnetic properties of the CBD-soluble component indicate that it formed as a result of in situ pedogenesis, which confirms our earlier conclusion that the palaeoclimate record of the loess/palaeosol sequence at the sites that we have sampled is primarily a record of pedogenesis.
Prediction of risk of coronary events in middle-aged men in the Prospective Cardiovascular Münster Study (PROCAM) using neural networks (2002)

Intervention trials indicate that about one in three coronary events can be prevented by 5 years of lipid-lowering treatment. Our analysis suggests that use of the MLP to identify high-risk individuals as candidates for drug treatment would allow prevention of 25% of coronary events in middle-aged men, compared to 15% and 11% with LR and the PNN, respectively.
Some solid‐state properties of blends of polyethylene terephthalate and polyamide‐6,6 (1982)

Abstract Polymer blends incorporating polyamide‐6,6 (PA) and polyethylene terephthalate (PET) and having the following PA wt,% concentrations were prepared: 0, 5, 10, 25, 30, 35, and 100. Samples were obtained by molding in a reciprocating‐screw injection‐molding machine. The samples were annealed to minimize frozen‐in stresses without increasing the crystallinity level in the material. Melting and heat‐of‐fnsion data, obtained with the differential scanning calorimeter, suggest an overall increased crystallinity in the blends, as indicated by a significant excess heat of fusion. Whereas the neat polymers exhibit ductile failure under both tensile and impact testing conditions, the blends show brittle behavior. Finally, the abrasion resistance of the blends is inferior to that observed for PET but higher than the resistance of PA.
Lung Transplantation From the Non-Heart Beating Donor (2008)

The inflated lung, with its unique tolerance of the absence of a circulation, is particularly suited to retrieval from the non-heart beating donor. Absence of some of the squeal of brain death may be a further potential advantage. This concept has been embraced by several centers around the world, with promising early results.
CRK proteins selectively regulate T cell migration into inflamed tissues (2015)

Effector T cell migration into inflamed sites greatly exacerbates tissue destruction and disease severity in inflammatory diseases, including graft-versus-host disease (GVHD). T cell migration into such sites depends heavily on regulated adhesion and migration, but the signaling pathways that coordinate these functions downstream of chemokine receptors are largely unknown. Using conditional knockout mice, we found that T cells lacking the adaptor proteins CRK and CRK-like (CRKL) exhibit reduced integrin-dependent adhesion, chemotaxis, and diapedesis. Moreover, these two closely related proteins exhibited substantial functional redundancy, as ectopic expression of either protein rescued defects in T cells lacking both CRK and CRKL. We determined that CRK proteins coordinate with the RAP guanine nucleotide exchange factor C3G and the adhesion docking molecule CASL to activate the integrin regulatory GTPase RAP1. CRK proteins were required for effector T cell trafficking into sites of inflammation, but not for migration to lymphoid organs. In a murine bone marrow transplantation model, the differential migration of CRK/CRKL-deficient T cells resulted in efficient graft-versus-leukemia responses with minimal GVHD. Together, the results from our studies show that CRK family proteins selectively regulate T cell adhesion and migration at effector sites and suggest that these proteins have potential as therapeutic targets for preventing GVHD.