gebhart/patrepeval huggingface dataset:
Mechanism of tonB-dependent transport of KP-736, a 1,5-dihydroxy-4-pyridone-substituted cephalosporin, into Escherichia coli K-12 cells (1995)

The mechanism of transport of KP-736, a novel cephalosporin with a 1,5-dihydroxy-4-pyridone moiety at the C-7 position, into the Escherichia coli K-12 cell was investigated by determining the susceptibilities of iron transport mutants to KP-736. The tonB mutant showed a higher degree of resistance to KP-736, indicating that KP-736 was incorporated into E. coli cells via the tonB-dependent iron transport system. The product of the exbB gene was also necessary for the maximal antibacterial potency of KP-736. Cir-lacking and Fiu-lacking mutants showed a moderate level of resistance to KP-736. However, mutants lacking any one of the proteins FepA, FecA, FhuA, and FhuE did not show any increased resistance to KP-736. Two types of spontaneous mutants (e.g., KT1004 and KT1011) could be isolated from cir and fiu mutants by selection for KP-736 resistance and showed the same level of resistance to KP-736 as a tonB mutant. KT1004 showed tonB phenotypes, resistance to phage phi 80, and loss of FecA, whereas KT1011 did not. KT1011 lost the ability to express both Cir and Fiu proteins. These results indicate that the Cir and Fiu outer membrane proteins are involved specifically in the tonB-dependent transport process of KP-736. Against OmpF- and OmpC-deficient transformants producing various groups of beta-lactamases, KP-736 was more effective than the other cephalosporins tested.
Electron spin resonance of palladium(I). IV. Mixed-ligand complexes of palladium(I) (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron spin resonance of palladium(I). IV. Mixed-ligand complexes of palladium(I)Michihiro Nakamura and Shizuo FujiwaraCite this: J. Phys. Chem. 1974, 78, 21, 2136–2140Publication Date (Print):October 1, 1974Publication History Published online1 May 2002Published inissue 1 October 1974https://pubs.acs.org/doi/10.1021/j100614a014https://doi.org/10.1021/j100614a014research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Interparticle Interactions in Glutathione Mediated Assembly of Gold Nanoparticles (2008)

The understanding of the detailed molecular interactions between (GSH) glutathione molecules in the assembly of metal nanoparticles is important for the exploitation of the biological reactivity. We report herein results of an investigation of the assembly of gold nanoparticles mediated by glutathione and the disassembly under controlled conditions. The interparticle interactions and reactivities were characterized by monitoring the evolution of the surface plasmon resonance band using the spectrophotometric method and the hydrodynamic sizes of the nanoparticle assemblies using the dynamic light scattering technique. The interparticle reactivity of glutathiones adsorbed on gold nanoparticles depends on the particle sizes and the ionic strength of the solution. Larger-sized particles were found to exhibit a higher degree of interparticle assembly than smaller-sized particles. The assembly-disassembly reversibility is shown to be highly dependent on pH and additives in the solution. The interactions of the negatively charged citrates surrounding the GSH monolayer on the particle surface were believed to produce more effective interparticle spatial and electrostatic isolation than the case of OH (-) groups surrounding the GSH monolayer. The results have provided new insights into the hydrogen-bonding character of the interparticle molecular interaction of glutathiones bound on gold nanoparticles. The fact that the interparticle hydrogen-bonding interactions in the assembly and disassembly processes can be finely tuned by pH and chemical means has implications to the exploitation of the glutathione-nanoparticle system in biological detection and biosensors.
Association of Upper Quarter Posture with Depression, Anxiety, and Level of Physical Activity in Sixth Grade Elementary School Students of Karaj City, Iran (2020)

<strong>Background:</strong> Postural abnormalities are prevalent among elementary school students. The aim of this study was to investigate the association of the upper quarter posture with depression, anxiety and level of physical activity in elementary school students of Karaj. <strong>Methods:</strong> In this cross-sectional study, 346 sixth grade students were randomly selected from 10 elementary schools. Levels of physical activity, anxiety, and depression were measured and the data were collected employing International Physical Activity Questionnaire-Short form (IPAQ-SF), Revised Children’s Manifest Anxiety Scale (RCMAS), and Children’s Depression Inventory (CDI), respectively. Photogrammetric method and a flexible ruler were used to assess the students’ posture. Pearson correlation test and linear regression model at the confidence level of 95% (P<0.05) was utilized to analyze the data. <strong>Results:</strong> There was a significant relation between depression and the craniovertebral angle (P=0.003); physical activity levels were also correlated with the sagittal head angle (P=0.012), and kyphosis (P=0.012). <strong>Conclusions:</strong> Certain postural abnormalities were associated with physical activity and psychological problems. Therefore, preventive actions are of great necessity to decrease postural and psychological problems.
Gene expression profiling of pre-eclamptic placentae by RNA sequencing (2015)

Pre-eclampsia is a common and complex pregnancy disorder that often involves impaired placental development. In order to identify altered gene expression in pre-eclamptic placenta, we sequenced placental transcriptomes of nine pre-eclamptic and nine healthy pregnant women in pools of three. The differential gene expression was tested both by including all the pools in the analysis and by excluding some of the pools based on phenotypic characteristics. From these analyses, we identified altogether 53 differently expressed genes, a subset of which was validated by qPCR in 20 cases and 19 controls. Furthermore, we conducted pathway and functional analyses which revealed disturbed vascular function and immunological balance in pre-eclamptic placenta. Some of the genes identified in our study have been reported by numerous microarray studies (BHLHE40, FSTL3, HK2, HTRA4, LEP, PVRL4, SASH1, SIGLEC6), but many have been implicated in only few studies or have not previously been linked to pre-eclampsia (ARMS2, BTNL9, CCSAP, DIO2, FER1L4, HPSE, LOC100129345, LYN, MYO7B, NCMAP, NDRG1, NRIP1, PLIN2, SBSPON, SERPINB9, SH3BP5, TET3, TPBG, ZNF175). Several of the molecules produced by these genes may have a role in the pathogenesis of pre-eclampsia, and some could qualify as biomarkers for prediction or detection of this pregnancy complication.
Narrow-band velocity selector for neutral particles (1988)

A velocity selector wheel of novel spiral groove design was constructed and successfully tested. The wheel can be used to select a narrow band (∼±1.2%) of velocities from a molecular beam while presenting an effective open time of 38%. No velocity sidebands are transmitted and alignment is relatively simple. Experimental measurements verified performance essentially as predicted.
Injection-locked harmonic self-oscillating mixer for variable phase-shifter applications in active microstrip phased antenna arrays (2005)

A new phase shifter element for use in active microstrip phased antenna arrays is presented. It is based on an injection-locked harmonic self-oscillating mixer, providing the double functionality of variable phase-shifter and down-converter. Maximum conversion gain is obtained, through the use of a new multiharmonic load at the input of the circuit. The ranges of synchronized operation are analyzed versus the circuit parameters, paying attention on the stability of the implemented circuit A 12 GHz to 3 GHz down-converter with a 4.5 GHz injection frequency has been designed, providing a stable phase-shift variation up to 360/spl deg/, with an 8 dB conversion gain.
A facile synthesis of UiO-66, UiO-67 and their derivatives (2013)

A scalable, reproducible method of synthesizing UiO-66- and UiO-67-type MOFs, entailing the addition of HCl to the reaction mixture, has been investigated. The new protocol requires a fraction of the time of previously reported procedures, yields exceptional porosities, and works with a range of linkers.
Synthesis of Glucuronides of Fluoropyrimidine Drugs: N- and O-Glucuronides of 5-Fluorocytosine and 5-Fluorouracil (1993)

Abstract The protected (4a-9a) and deprotected (4b-6b, 8b) glucuronides of 5-fluorocytosine and 5-fluorouracil were synthesized and characterized by mass spectrometry and 19F, 1H and 13C NMR. The substitution position of the sugar moiety on the pyrimidine ring was determined from the 13C NMR chemical shift of the C1′ of the sugar. The α or β configuration of the glucuronide linkage was assigned on the basis of the value of the coupling constant between H1′ and H2′ of the sugar.
Study on a Luminol-based Electrochemiluminescent Sensor for Label-Free DNA Sensing (2010)

Automatic, inexpensive, simple and sensitive methods for DNA sensing and quantification are highly desirable for biomedical research. The rapid development of both the fundamentals and applications of electrochemiluminescence (ECL) over the past years has demonstrated its potential for analytical and bio-analytical chemistry. This paper reports the quenching effect of DNA on the ECL of luminol and the further development of a DNA sensing device. With the pre-functionalization by a composite of carbon nano-tubes (CNTs) and Au nanoparticles (AuNPs), the sensor provides a novel and valuable label-free approach for DNA sensing. Here the ECL intensity was remarkably decreased when more than 1.0 × 10(-12) molar of DNA were adsorbed on the sensor. Linearity of the DNA amount with the reciprocal of ECL intensity was observed. A saturated sensor caused a 92.8% quenching effect. The research also proposes the mechanism for the quenching effect which could be attributed to the interaction between luminol and DNA and the elimination of reactive oxygen species (ROSs) by DNA.
Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo (2010)

These results indicate that inhibition of FGFR1 and wild-type or mutant FGFR3 may represent a useful therapeutic approach in patients with both non-muscle invasive and muscle invasive UC.
G‐CSF induces elevation of circulating CA 15‐3 in breast carcinoma patients treated in an adjuvant setting (2001)

BACKGROUND Cancer antigen 15-3 (CA 15-3), a circulating marker that determines secreted products of the polymorphic MUC1 gene, has been established as a convenient tool for monitoring breast carcinoma patients. METHODS The authors investigated alterations of soluble CA 15-3 in 57 postoperative breast carcinoma patients while they were receiving intensified adjuvant chemotherapy with granulocyte colony stimulating factor (G-CSF) support; 26 patients had American Joint Committee on Cancer (AJCC) Stage II, and 31 patients had AJCC Stage III breast carcinoma. Serial CA 15-3 values recorded thoughout the treatment were compared with baseline values, analyzed for correlation with hematologic and biochemical parameters, and compared with clinicopathologic characteristics and patient outcome. At a median follow-up time of 32 months, 47 of these patients remained relapse-free. RESULTS A twofold increase of CA 15-3 was detected at the end of the second week of treatment, remained significantly elevated in most patients at above the cutoff level of 30 U/mL throughout the treatment period (P < 0.0001), and subsided to pretreatment values 1–2 months after treatment cessation. CA 15-3 values were found to be associated strongly with absolute neutrophil count, serum lactate dehydrogenase, and alkaline phosphatase. The median values and the kinetics of tumor markers did not differ over time in regard to hormonal receptor status and disease recurrence. CONCLUSIONS These data provide strong evidence that G-CSF administration can induce elevation of CA 15-3 and indicate that false-positive results should be considered when evaluating CA 15-3 in patients who are receiving G-CSF. It is speculated that this phenomenon occurs through the induction of MUC1 antigen of unknown origin by G-CSF. Experimental investigation of this clinical observation is warranted. Cancer 2001;91:909–17. © 2001 American Cancer Society.
A Comparison of Mixed-Integer Programming Models for Nonconvex Piecewise Linear Cost Minimization Problems (2003)

We study a generic minimization problem with separable nonconvex piecewise linear costs, showing that the linear programming (LP) relaxation of three textbook mixed-integer programming formulations each approximates the cost function by its lower convex envelope. We also show a relationship between this result and classical Lagrangian duality theory.
Personalizing Software and Web Services by Integrating Unstructured Application Usage Traces (2017)

Users of software applications generate vast amounts of unstructured log-trace data. These traces contain clues to the intentions and interests of those users, but service providers may find it difficult to uncover and exploit those clues. In this paper, we propose a framework for personalizing software and web services by leveraging such unstructured traces. We use 6 months of Photoshop usage history and 7 years of interaction records from 67K Behance users to design, develop, and validate a user-modeling technique that discovers highly discriminative representations of Photoshop users; we refer to the model as cutilization-to-vector, util2vec. We demonstrate the promise of this approach for three sample applications: (1) a practical user-tagging system that automatically predicts areas of focus for millions of Photoshop users; (2) a two-phase recommendation model that enables cold-start personalized recommendations for many new Behance users who have Photoshop usage data, improving recommendation quality ([email protected]) by 21.2% over a popularity-based recommender; and (3) a novel inspiration engine that provides real-time personalized inspirations to artists. We believe that this work demonstrates the potential impact of unstructured usage-log data for personalization.
Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis (2007)

Recent studies have demonstrated a strong relationship between aging-associated reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin resistance. Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitochondrial biogenesis, we examined AMPK activity in young and old rats and found that acute stimulation of AMPK-alpha(2) activity by 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and exercise was blunted in skeletal muscle of old rats. Furthermore, mitochondrial biogenesis in response to chronic activation of AMPK with beta-guanidinopropionic acid (beta-GPA) feeding was also diminished in old rats. These results suggest that aging-associated reductions in AMPK activity may be an important contributing factor in the reduced mitochondrial function and dysregulated intracellular lipid metabolism associated with aging.
Schooling in China (2020)

This chapter traces the historical roots of Chinese schooling and offers an overview of contemporary educational development in China, with a particular focus on prominent policy initiatives and challenges ahead. Government schooling was rebuilt during the Sui Dynasty and flourished during the Tang Dynasty. The Tang period being one of progress and stability saw the Chinese empire flourish. As for regional government schooling, the Ming Dynasty inherited those from the preceding Yuan Dynasty, with schools at various levels offering medical, yin and yang and martial arts education, as well as a widespread Shexue system in rural areas. While many tend to agree that Chinese schooling faces serious challenges, few are able to accurately diagnose its illness. A deeper problem is that a Western-styled school system has only been taken for its practicality. At the centre of governance reform is the school-government relationship.
In vivo trans-specific gene silencing in fungal cells by in planta expression of a double-stranded RNA (2010)

The results provide a powerful tool for further studies on molecular plant-microbe and symbiotic interactions. From a biotechnological perspective, silencing of fungal genes by generating siRNAs in the host provides a novel strategy for the development of broad fungi-resistance strategies in plants and other organisms.
Interface-Induced Disassembly of a Self-Assembled Two-Component Nanoparticle System (2013)

We present a study of static and dynamic interfacial properties of self-assembled polyelectrolyte complex nanoparticles (size 110-120 nm) containing entrapped surfactant molecules at a fluid/fluid interface. Surface tension vs time measurements of an aqueous solution of these polyelectrolyte complex nanoparticles (PCNs) show a concentration-dependent biphasic adsorption to the air/water interface while interfacial microrheology data show a concentration-dependent initial increase in the surface viscosity (up to 10(-7) N·m/s), followed by a sharp decrease (10(-9) N·m/s). Direct visualization of the air/water interface shows disappearance of particles from the interface over time. On the basis of these observations, we propose that the PCNs at fluid/fluid interfaces exist in two states: initial accumulation of PCNs at the air/water interface as nanoparticles, followed by interface induced disassembly of the accumulated PCNs into their components. The lack of change in particle size, charge, and viscosity of the bulk aqueous solution of PCNs with time indicates that this disintegration of the self-assembled PCNs is an interfacial phenomenon. Changes in energy encountered by the PCNs at the interface lead to instability of the self-assembled system and dissociation into its components. Such systems can be used for applications requiring directed delivery and triggered release of entrapped surfactants or macromolecules at fluid/fluid interfaces.
Advancing the Use and Quality of Peritoneal Dialysis by Developing a Peritoneal Dialysis Satellite Center Program (2010)

Our PD satellite center program is a good model for increasing the use and improving the quality of PD in rural areas. We plan to expand this program to other parts of southern China.
Anthocyanins Isolated from Purple Corn(Zea mays L.) (2002)

Six anthocyanins were isolated from Peruvian purple corn seed (Zea mays L.) as raw material for a food colorant, and their complete structures were determined by means of spectroscopic analyses. The major anthocyanin was cyanidin 3-O-β-D-glucoside. The other five anthocyanins were pelargonidin 3-O-β-D-glucoside, peonidin 3-O-β-D-glucoside, cyanidin 3-O-β-D-(6-malonyl-glucoside), pelargonidin 3-O-β-D-(6-malonyl-glucoside) and peonidin 3-O-β-D-(6-malonyl-glucoside). Pelargonidin 3-O-β-D-(6-malonyl-glucoside) was found in purple corn for the first time. The cyanidin derivatives constitute around 70% in purple corn seed.
The motion transform: a new motion compensation technique (2002)

Motion estimation plays an important role in video coding schemes by removing temporal redundancies that exist in image sequences. Motion information that is required in motion compensated prediction is transmitted as side information, as in forward motion estimation, or can be computed at the receiver in backward motion estimation. The former method has the advantage of more accurate prediction but, suffers in that the motion information is transmitted as side information. We introduce the motion transform (MT), a new motion estimation and compensation technique that does not require the transmission of motion vectors yet, performs well under a variety of conditions. In the proposed method, motion information is obtained in a bottom-up hierarchical fashion using a two-dimensional wavelet-like decomposition. By using a nonlinear non-expansive filter bank a hierarchical decomposition of the image allows coarse-to-fine motion compensation at the decoder without motion vector transmission.
Effect of Supplemental Dietary Chromium or Nicotinic Acid on Carbohydrate Metabolism During Basal, Starvation, and Refeeding Periods in Poults (1981)

A series of experiments were conducted with turkey poults to ascertain the effects of supplemental chromium or excess of nicotinic acid on growth and carbohydrate metabolism. A 23% protein starter diet was selected to emphasize the effect of chromium under basal, starvation for 48 hr, and refeeding periods. Thirty percent protein diets were also used to determine if the effects were compounded by protein levels. Supplemental chromium (20 ppm) significantly increased (P less than .05) weight at 3 weeks of age of poults consuming 23% protein diets, while an additional 250 ppm of nicotinic acid had little effect on poult weight at 3 weeks (P greater than .05). Supplemental chromium did not increase (P greater than .05) feed consumption of poults consuming both 23 and 30% protein diets. Supplemental chromium increased liver glycogen at 3 weeks of age and following refeeding after the 48 hr fast (P less than .05). Blood glucose was significantly affected by starvation-refeeding (P less than .05) but was not affected by either chromium or nicotinic acid. Supplemental chromium increased (P less than .01) active glycogen synthetase, while nicotinic acid increased (P less than .01) active phosphorylase at both protein levels. Synthetase was not decreased by starvation but was increased (P less than .01) by refeeding regardless of protein level fed. Phosphorylase was not affected by a starvation-refeeding regimen. Chromium supplementation increased in the vitro incorporation of (14C) glucose into glycogen during basal, starvation and refeeding periods (P less than .01), again, regardless of protein level.
A Distributed Programs Monitor for Berkeley UNIX (1984)

Abstract Writing and debugging distributed programs can be difficult. When a program is working, it can be difficult to achieve reasonable execution performance. A major cause of these difficulties is a lack of tools for the programmer. We use a model of distributed computation and measurement to implement a program monitoring system for programs running on the Berkeley UNIX 4.2BSD operating system. The model of distributed computation describes the activities of the processes within a distributed program in terms of computation (internal events) and communication (external events). The measurement model focuses on external events and separates the detection of external events, event record selection and data analysis. The implementation of the measurement tools involved changes to the Berkeley UNIX kernel, and the addition of daemon processes to allow the monitoring activity to take place across machine boundaries. A user interface has also been implemented.