gebhart/patrepeval huggingface dataset:
An iterative algorithm for placement and assignment of integrated circuits (1975)

In [1] a physical design automation system with a unified approach to physical layout techniques was presented. This method has been extended so that it now is an iterated, assignment placement algorithm which improves the placements reported last year.The problems to be addressed in this paper are those of assignment, placement, and spanning. Assignment is the process of assigning logical elements to integrated circuit chips. Placement is the process of placing integrated circuits on a board. Spanning is the process of converting a set of points which must be connected, to a wire list specifying the manner of connection. There are a number of criteria used to span. In this application, we have the option to use either Kruskal's spanning algorithm [2] or a chaining spanner [3]. The goal of these two processes is to increase the routability of the resulting board, which is often measured by the overall length of wire required (Manhattan distance).
The branched-chain fatty acids of mutton fat. 2. The isolation of (+)-12-methyltetradecanoic acid and of 13-methyltetradecanoic acid (1953)

Research Article| February 01 1953 The branched-chain fatty acids of mutton fat. 2. The isolation of (+)-12-methyltetradecanoic acid and of 13-methyltetradecanoic acid R. P. Hansen; R. P. Hansen 1Fats Research Laboratory, Department of Scientific and Industrial Research, Wellington, New Zealand Search for other works by this author on: This Site PubMed Google Scholar F. B. Shorland; F. B. Shorland 1Fats Research Laboratory, Department of Scientific and Industrial Research, Wellington, New Zealand Search for other works by this author on: This Site PubMed Google Scholar N. J. Cooke N. J. Cooke 1Fats Research Laboratory, Department of Scientific and Industrial Research, Wellington, New Zealand Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1953) 53 (3): 374–379. https://doi.org/10.1042/bj0530374 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation R. P. Hansen, F. B. Shorland, N. J. Cooke; The branched-chain fatty acids of mutton fat. 2. The isolation of (+)-12-methyltetradecanoic acid and of 13-methyltetradecanoic acid. Biochem J 1 February 1953; 53 (3): 374–379. doi: https://doi.org/10.1042/bj0530374 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1953 CAMBRIDGE UNIVERSITY PRESS1953 Article PDF first page preview Close Modal You do not currently have access to this content.
LOC401317, a p53-Regulated Long Non-Coding RNA, Inhibits Cell Proliferation and Induces Apoptosis in the Nasopharyngeal Carcinoma Cell Line HNE2 (2014)

Recent studies have revealed that long non-coding RNAs participate in all steps of cancer initiation and progression by regulating protein-coding genes at the epigenetic, transcriptional, and post-transcriptional levels. Long non-coding RNAs are in turn regulated by other genes, forming a complex regulatory network. The regulation networks between the p53 tumor suppressor and these RNAs in nasopharyngeal carcinoma remains unclear. The aims of this study were to investigate the regulatory roles of the TP53 gene in regulating long non-coding RNA expression profiles and to study the function of a TP53-regulated long non-coding RNA (LOC401317) in the nasopharyngeal carcinoma cell line HNE2. Long non-coding RNA expression profiling indicated that 133 long non-coding RNAs were upregulated in the human NPC cell line HNE2 cells following TP53 overexpression, while 1057 were downregulated. Among these aberrantly expressed long non-coding RNAs, LOC401317 was the most significantly upregulated one. Further studies indicated that LOC401317 is directly regulated by p53 and that ectopic expression of LOC401317 inhibits HNE2 cell proliferation in vitro and in vivo by inducing cell cycle arrest and apoptosis. LOC401317 inhibited cell cycle progression by increasing p21 expression and decreasing cyclin D1 and cyclin E1 expression and promoted apoptosis through the induction of poly(ADP-ribose) polymerase and caspase-3 cleavage. Collectively, these results suggest that LOC401317 is directly regulated by p53 and exerts antitumor effects in HNE2 nasopharyngeal carcinoma cells.
Fundamentals of Rolling Resistance (2001)

Abstract Increasing pressure over the last three decades to improve vehicle fuel economy and decrease emissions along with a strong sense of environmental stewardship has driven the tire and rubber industries to reduce tire rolling resistance. This has been accomplished while simultaneously improving other aspects of tire performance dramatically. Reductions in rolling resistance of 50% relative to 1980 levels have been realized, and efforts continue to decrease rolling resistance further. Laboratory measurement and empirical modeling of rolling resistance behavior have evolved substantially, and the tire industry can characterize a tire's rolling resistance with great precision and accuracy. Rolling resistance behavior is quite complex, and nearly all conceivable operating conditions have a measurable effect. The effect of each parameter has received considerable attention in the archival literature, and this review highlights the conclusions of these studies. One of the most powerful tools available to the tire industry is numerical modeling. Combined with accurate dynamic material property measurements, finite element models have provided designers with a tool to understand the behavior of each rubber product and optimize tire construction and material properties to minimize rolling resistance. However, with the current level of understanding and optimization of rolling resistance, substantial breakthroughs in the areas of material development and tire construction are needed to achieve further rolling resistance reductions.
IMPORTANCIA DE LA PERCEPCIÓN DE EFICACIA PARA LA MEJORA DE LA COHESIÓN EN EL FÚTBOL (2008)

This study aims to examine the relationships among self-efficacy, coaches’ perception of efficacy and teammate’s perception of efficacy regarding team cohesion. The sample comprised 66 players recruited from four semi-professional football teams. Results showed that coaches` perception of efficacy have a greater relationship with task cohesion, whereas teammates` perception of efficacy is associated with social cohesion. Finally, we suggest that teammates or coaches perception of efficacy are positively associated with cohesiveness, emphasizing the recognition by coach and group of the importance of every player and the role they are playing.
SAMSum Corpus: A Human-annotated Dialogue Dataset for Abstractive Summarization (2019)

This paper introduces the SAMSum Corpus, a new dataset with abstractive dialogue summaries. We investigate the challenges it poses for automated summarization by testing several models and comparing their results with those obtained on a corpus of news articles. We show that model-generated summaries of dialogues achieve higher ROUGE scores than the model-generated summaries of news -in contrast with human evaluators' judgement. This suggests that a challenging task of abstractive dialogue summarization requires dedicated models and non-standard quality measures. To our knowledge, our study is the first attempt to introduce a high-quality chatdialogues corpus, manually annotated with abstractive summarizations, which can be used by the research community for further studies.
Photon-counting technique for rapid fluorescence-decay measurement (1998)

We report on a novel laser-induced fluorescence triple-integration method (LIFTIME) that is capable of making rapid, continuous fluorescence lifetime measurements by a unique photon-counting technique. The LIFTIME has been convolved with picosecond time-resolved laser-induced fluorescence, which employs a high-repetition-rate mode-locked laser, permitting the eventual monitoring of instantaneous species concentrations in turbulent flames. We verify the technique by application of the LIFTIME to two known fluorescence media, diphenyloxazole (PPO) and quinine sulfate monohydrate (QSM). PPO has a fluorescence lifetime of 1.28 ns, whereas QSM has a fluorescence lifetime that can be varied from 1.0 to 3.0 ns. From these liquid samples we demonstrate that fluorescence lifetime can currently be monitored at a sampling rate of up to 500 Hz with less than 10% uncertainty (1 sigma) .
DiffServ-based Service-specific VCM in DVB-S2 (2007)

In view of the increasing number of bandwidth-intensive services, expensive satellite links demand measures for a controlled flow of data, effectively complementing the improvements of coding and transmission techniques introduced in emerging standards such as DVB-S2. This paper proposes a QoS approach for IP-based services over DVB-S2 links by exploiting DVB-S2 variable coding and modulation capabilities without requiring feedback from the receiving side. The concept is based on the selection of suitable ModCods for particular information flows depending on their types of service, rather than on the reception quality reported back to the hub station.
Traditional Chinese medicine for epilepsy (2014)

This review has been withdrawn as the original review author team are unable to update the review. We hope to reallocate to another review author team in the near future.
Communication: A Facile Synthesis of a Glycoconjugate Cationic Polymer Carrying the 3,6-Branched α-D-Mannosyl Trisaccharide Cluster (2000)

Abstract Receptor-mediated gene transfection1 has gained central interests since Wu and Wu2 demonstrated successful gene transfection into hepatocytes by using an asialoglycoprotein-poly(L-lysine) complex as a nonviral gene vector. Besides the hepatoma cells possessing galactose-specific receptor proteins, macrophages bearing mannose-specific receptors can also become a target of the gene transfection.3-5 Though partially mannosylated poly(L-lysine)3,4 and mannosylated avidin5 have been tested for this purpose, development of more effective vectors with higher cytoselectivity is required for gene therapies. As a part of our research efforts to develop and apply artificial glycoconjugate polymers carrying biologically active oligosaccharides,6-8 our interest has been directed to the potential utility of 3,6-branched α-D-mannoside for the receptor mediated gene transfer targeting macrophages. The 3,6-branched mannosyl trisaccharide is reported to be the much better ligand of mannose-specific binding proteins than mono- and linear oligomannosides.9 In this communication, we report a facile synthesis of a glycoconjugate cationic polymer carrying the 3,6-branched α-D-mannoside cluster10,11 and evaluate its binding affinity to a mannose-specific lectin, concanavalin A.
Cerebrovascular Alterations in Protein Kinase C–Mediated Constriction in Stroke-Prone Rats (1999)

Phorbol esters interact with the same activation site as diacylglycerol to stimulate PKC. An inability to constrict in response to phorbol dibutyrate may reflect unresponsiveness to diacylglycerol and may contribute to the loss of pressure-dependent constriction associated with stroke in the MCAs of SHRsp. The loss of this autoregulatory function before stroke could increase the risk of cerebral hemorrhage.
<i>Tmc</i> gene therapy restores auditory function in deaf mice (2015)

Genetic hearing loss accounts for up to 50% of prelingual deafness worldwide, yet there are no biologic treatments currently available. To investigate gene therapy as a potential biologic strategy for restoration of auditory function in patients with genetic hearing loss, we tested a gene augmentation approach in mouse models of genetic deafness. We focused on DFNB7/11 and DFNA36, which are autosomal recessive and dominant deafnesses, respectively, caused by mutations in transmembrane channel-like 1 (TMC1). Mice that carry targeted deletion of Tmc1 or a dominant Tmc1 point mutation, known as Beethoven, are good models for human DFNB7/11 and DFNA36. We screened several adeno-associated viral (AAV) serotypes and promoters and identified AAV2/1 and the chicken β-actin (Cba) promoter as an efficient combination for driving the expression of exogenous Tmc1 in inner hair cells in vivo. Exogenous Tmc1 or its closely related ortholog, Tmc2, were capable of restoring sensory transduction, auditory brainstem responses, and acoustic startle reflexes in otherwise deaf mice, suggesting that gene augmentation with Tmc1 or Tmc2 is well suited for further development as a strategy for restoration of auditory function in deaf patients who carry TMC1 mutations.
A novel 2.5D pattern for extrinsic calibration of tof and camera fusion system (2011)

Recently, many researchers have made efforts for accurate calibration of a Time-of-Flight camera to fully utilize its provided depth values. Yet most previous works focus mainly on intrinsic calibration by modeling its systematic errors and noises while extrinsic calibration is also an important factor when constructing sensor fusion system. In this paper, we present a calibration process that can correctly transfer the depth measurements onto the color image. We use 2.5D pattern so that sufficient reprojection error can be considered for both color and ToF cameras. The issues on obtaining the correct correspondences for this pattern are discussed. In the optimization stage, the depth constraint is also employed to ensure the depth measurements to lie on the pattern plane. The strengths of the proposed method over previous approaches are evaluated in several robotic applications which require precise ToF and camera calibration.
Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017 (2017)

Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood to optimize pharmacotherapy. It considers the interindividual variability of pharmacokinetics and thus enables personalized pharmacotherapy. In psychiatry and neurology, patient populations that may particularly benefit from TDM are children and adolescents, pregnant women, elderly patients, individuals with intellectual disabilities, patients with substance abuse disorders, forensic psychiatric patients or patients with known or suspected pharmacokinetic abnormalities. Non-response at therapeutic doses, uncertain drug adherence, suboptimal tolerability, or pharmacokinetic drug-drug interactions are typical indications for TDM. However, the potential benefits of TDM to optimize pharmacotherapy can only be obtained if the method is adequately integrated in the clinical treatment process. To supply treating physicians and laboratories with valid information on TDM, the TDM task force of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) issued their first guidelines for TDM in psychiatry in 2004. After an update in 2011, it was time for the next update. Following the new guidelines holds the potential to improve neuropsychopharmacotherapy, accelerate the recovery of many patients, and reduce health care costs.
Enabling on-demand internet video streaming services to multi-terminal users in large scale (2009)

In the ubiquitous era of streaming multimedia over the Internet, an increasing number of users are accessing to Internet video services through varieties of terminals, e.g PC, Set-Top Box IPTV and mobile phones, etc. Whereas extending streaming media to multiple ends adds much to consumer electronic industry, the challenge remains on how to provide on-demand services to heterogeneous users with different bandwidth requirement, access manner, QoS demand, etc. The success of a large-scale video streaming system relies heavily on how they address the critical issues in QoS, scalability and heterogeneity, yet no single system has delivered the expected scale and quality for commercial applications. Thus this paper provides a complete portfolio of solutions for providing multiple Internet video streaming services (live video broadcast, video on demand, video downloading) on 3 Screens (PC, TV, mobile), through a unified Peer-to-Peer (P2P) video platform. Upon manageable P2P framework, different terminals access are supported and end user bandwidth are utilized to scale the system. With our multi-process server management, efficient topology organization, enhanced UDP transmission and intelligent content distribution, our P2P streaming media platform is proved to have lower operation cost and higher user quality. The significance of such paper lies not only in the proposed system framework and on-field engineering techniques to enable an enterprise-grade and telecom-class application, but also the industrial insights inside designing such commercialized large-scale platform with full consideration of function, process, configuration and cost <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> .
The detection of fault-prone programs (1992)

The use of the statistical technique of discriminant analysis as a tool for the detection of fault-prone programs is explored. A principal-components procedure was employed to reduce simple multicollinear complexity metrics to uncorrelated measures on orthogonal complexity domains. These uncorrelated measures were then used to classify programs into alternate groups, depending on the metric values of the program. The criterion variable for group determination was a quality measure of faults or changes made to the programs. The discriminant analysis was conducted on two distinct data sets from large commercial systems. The basic discriminant model was constructed from deliberately biased data to magnify differences in metric values between the discriminant groups. The technique was successful in classifying programs with a relatively low error rate. While the use of linear regression models has produced models of limited value, this procedure shows great promise for use in the detection of program modules with potential for faults.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
On traces for functional spaces related to Maxwell's equations Part II: Hodge decompositions on the boundary of Lipschitz polyhedra and applications (2001)

Hodge decompositions of tangential vector fields defined on piecewise regular manifolds are provided. The first step is the study of L2 tangential fields and then the attention is focused on some particular Sobolev spaces of order $-{1\over 2}$\nopagenumbers\end. In order to reach this goal, it is required to properly define the first order differential operators and to investigate their properties. When the manifold Γ is the boundary of a polyhedron Ω, these spaces are important in the analysis of tangential trace mappings for vector fields in H(curl, Ω) on the whole boundary or on a part of it. By means of these Hodge decompositions, one can then provide a complete characterization of these trace mappings: general extension theorems, from the boundary, or from a part of it, to the inside; definition of suitable dualities and validity of integration by parts formulae. Copyright © 2001 John Wiley & Sons, Ltd.
Properties of intercalated 2H-NbSe2, 4Hb-TaS2, and 1T-TaS2 (1975)

The layered compounds 2H-NbSe2, 4Hb-TaS2, and 1T-TaS2 have been intercalated with organic molecules; and the resulting crystal structure, heat capacity, conductivity, and superconductivity have been studied. The coordination in the disulfide layers was found to be unchanged in the product phase. Resistance minima appear and the superconducting transition temperature is reduced in the NbSe2 complex. Conversely, superconductivity is induced in the 4Hb-TaS2 complex. Corresponding evidence of a large change of the density of states, negative for 2H-NbSe2 and positive for 4Hb-TaS2, was also observed upon intercalation. The transport properties of all the intercalation complexes show a pronounced dependence upon the coordination of the transition metal.
Intrinsic safety circuit design (1992)

Intrinsic safety prevents instruments and other low-voltage circuits in hazardous areas from releasing sufficient energy to ignite volatile gases. Although it is used widely in Europe to safely install and operate instrumentation circuits in hazardous areas, it has caused much confusion in North American markets. Many users have heard of it and want to know more; however, most feel uncomfortable applying intrinsically safe products. One reason is that intrinsic safety has been a part of Section 504 of the National Electric Code only since 1990. In addition, the number of different products on the market and seemingly endless calculations make applying intrinsic safety seem like an engineer’s nightmare.
Nurr1 (NR4A2) regulates Alzheimer’s disease‐related pathogenesis and cognitive function in the 5XFAD mouse model (2018)

The orphan nuclear receptor Nurr1 (also known as NR4A2) is critical for the development and maintenance of midbrain dopaminergic neurons, and is associated with Parkinson's disease. However, an association between Nurr1 and Alzheimer's disease (AD)-related pathology has not previously been reported. Here, we provide evidence that Nurr1 is expressed in a neuron-specific manner in AD-related brain regions; specifically, it is selectively expressed in glutamatergic neurons in the subiculum and the cortex of both normal and AD brains. Based on Nurr1's expression patterns, we investigated potential functional roles of Nurr1 in AD pathology. Nurr1 expression was examined in the hippocampus and cortex of AD mouse model and postmortem human AD subjects. In addition, we performed both gain-of-function and loss-of-function studies of Nurr1 and its pharmacological activation in 5XFAD mice. We found that knockdown of Nurr1 significantly aggravated AD pathology while its overexpression alleviated it, including effects on Aβ accumulation, neuroinflammation, and neurodegeneration. Importantly, 5XFAD mice treated with amodiaquine, a highly selective synthetic Nurr1 agonist, showed robust reduction in typical AD features including deposition of Aβ plaques, neuronal loss, microgliosis, and impairment of adult hippocampal neurogenesis, leading to significant improvement of cognitive impairment. These in vivo and in vitro findings suggest that Nurr1 critically regulates AD-related pathophysiology and identify Nurr1 as a novel AD therapeutic target.
Calibration Method Simulation of Linear-array Hydrophone in Underwater Acoustic Network (2019)

Aiming at the problem that the amplitude and phase consistency of linear-array hydrophones in underwater acoustic network is difficult to calibrate accurately, this paper proposes a straightforward, high-accuracy calibration method for amplitude and phase of linear hydrophones arrays. First, the hydrophone array is submerged vertically far field of the transmitting transducer, and then the hydrophone array is lifted by a mechanical lifting device without horizontal movement during lifting. Each hydrophone receives and records the signals when it is at the same depth as the transmitting transducer. All the signals received are intercepted and proposed by Fourier transformation to obtain the amplitude-frequency and phase-frequency characteristic curves. Amplitude and phase values corresponding to a given frequency can be determined from these curves. This paper also analyzes the feasibility of the method and several factors which may cause measurement error during simulation. Finally, the calibration of the linear-array hydrophones in underwater acoustic network with ten elements is performed in the laboratory tank. Its results show that the method is effective in calibrating hydrophones for amplitude and phase and easier to operate than any other methods.