gebhart/patrepeval huggingface dataset:
Deletion of the 5′‐ABL region: a recurrent anomaly detected by fluorescence <i>in situ</i> hybridization in about 10% of Philadelphia‐positive chronic myeloid leukaemia patients (2000)

Inclusion of the BCR-ABL ES probe in routine cytogenetics led to the identification of a subgroup of Philadelphia positive (Ph+) chronic myeloid leukaemia patients characterized by a 5'-ABL deletion. This anomaly was observed in 5/51 cases (9.8%). Cytological and clinical data suggest that the 5'-ABL deletion may be associated with dysplastic features of polymorphonuclear cells and metamyelocytes and a short chronic phase duration.
Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor (2013)

Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure. Given the multiple beneficial effects of the mitochondrial division inhibitor (mdivi-1) in a variety of pathological conditions including heart failure and ischaemia and reperfusion injury, we investigated the effects of mdivi-1 on doxorubicin-induced cardiac dysfunction in naïve and stressed conditions using Langendorff perfused heart models and a model of oxidative stress was used to assess the effects of drug treatments on the mitochondrial depolarisation and hypercontracture of cardiac myocytes. Western blot analysis was used to measure the levels of p-Akt and p-Erk 1/2 and flow cytometry analysis was used to measure the levels p-Drp1 and p-p53 upon drug treatment. The HL60 leukaemia cell line was used to evaluate the effects of pharmacological inhibition of mitochondrial division on the cytotoxicity of doxorubicin in a cancer cell line. Doxorubicin caused a significant impairment of cardiac function and increased the infarct size to risk ratio in both naïve conditions and during ischaemia/reperfusion injury. Interestingly, co-treatment of doxorubicin with mdivi-1 attenuated these detrimental effects of doxorubicin. Doxorubicin also caused a reduction in the time taken to depolarisation and hypercontracture of cardiac myocytes, which were reversed with mdivi-1. Finally, doxorubicin caused a significant elevation in the levels of signalling proteins p-Akt, p-Erk 1/2, p-Drp1 and p-p53. Co-incubation of mdivi-1 with doxorubicin did not reduce the cytotoxicity of doxorubicin against HL-60 cells. These data suggest that the inhibition of mitochondrial fission protects the heart against doxorubicin-induced cardiac injury and identify mitochondrial fission as a new therapeutic target in ameliorating doxorubicin-induced cardiotoxicity without affecting its anti-cancer properties.
Branched polymer via free radical polymerization of chain transfer monomer: A theoretical and experimental investigation (2007)

Abstract A simple mathematic model for the free radical polymerization of chain transfer monomers containing both polymerizable vinyl groups and telogen groups was proposed. The molecular architecture of the obtained polymer can be prognosticated according to the developed model, which was validated experimentally by homopolymerization of 4‐vinyl benzyl thiol (VBT) and its copolymerization with styrene. The chain transfer constant ( C T ) of telogen group in a chain transfer monomer is considered to play an important role to determine the architecture of obtained polymer according to the proposed model, either in homopolymerization or copolymerization. A highly branched polymer will be formed when the C T value is around unity, while a linear polymer with a certain extent of side chains will be obtained when the C T value is much bigger or smaller than unity. The C T of VBT was determined to be around 15 by using the developed model and 1 H NMR monitored experiments. The obtained poly(VBT) and its copolymers were substantiated to be mainly consisted of linear main chain with side branching chains, which is in agreement with the anticipation from the developed model. The glass transition temperature, number average molecular weight, and its distribution of those obtained polymer were primarily investigated. This model is hopefully to be used as a strategy to select appropriate chain transfer monomers for preparing hyperbranched polymers. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 1449–1459, 2008
Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor. (1995)

In most tissues IGF2 is expressed from the paternal allele while H19 is expressed from the maternal allele. We have previously shown that in some Wilms tumors the maternal IGF2 imprint is relaxed such that the gene is expressed biallelically. We have now investigated this subset of tumors further and found that biallelic expression of IGF2 was associated with undetectable or very low levels of H19 expression. The relaxation of IGF2 imprinting in Wilms tumors also involved a concomitant reversal in the patterns of DNA methylation of the maternally inherited IGF2 and H19 alleles. Furthermore, the only specific methylation changes that occurred in tumors with relaxation of IGF2 imprinting were solely restricted to the maternal IGF2 and H19 alleles. These data suggest that there has been an acquisition of a paternal epigenotype in these tumors as the result of a pathologic disruption in the normal imprinting of the IGF2 and H19 genes.
Intra- and Intergeneric Similarities of the rRNA Cistrons of Alteromonas, Marinomonas (gen. nov.) and Some Other Gram-negative Bacteria (1983)

14C-labelled rRNA was prepared from Alteromonas macleodii ATCC 27126 and from Alteromonas haloplanktis ATCC 14393. 3H-labelled rRNA was isolated from Alteromonas vaga ATCC 27119 and Alteromonas putrefaciens ATCC 8071 colony type tl. These rRNAs were hybridized under stringent conditions with filter-fixed DNA from various Alteromonas strains and from organisms of marine origin and/or with mol % G + C values in the range 40 to 50. Each hybrid was described by its Tm(e) and percentage of rRNA binding. From rRNA similarity maps and Tm(e) dendrograms the following conclusions were drawn. The genus Alteromonas is very heterogeneous and consists of four rRNA branches: (1) Alt. macleodii alone; (2) the Alt. haloplanktis cluster, containing most of the named Alteromonas species and a number of organisms which should be renamed Alteromonas (‘Pseudomonas marinoglutinosa’, ‘Pseudomonas nigrifaciens’, ‘Pseudomonas atlantica’ ATCC 19262, ‘Pseudomonas carrageenovora’, ‘Pseudomonas piscicida’, and several unnamed alginolytic bacteria); we propose to limit the genus Alteromonas to the former two clusters; (3) Alt. putrefaciens, the rRNA cistrons of which resemble those of the Vibrionaceae and are as different from the above two Alteromonas rRNA branches as are those of the Vibrionaceae, the Enterobacteriaceae and Aeromonas; ‘Pseudomonas rubescens’ belongs to this branch and Alteromonas hanedai seems to be a remote relative; (4) Alteromonas communis and Alt. vaga constitute another, separate rRNA branch; in conjunction with their special phenotypic features, we propose to create a new genus, Marinomonas, for them. The exact taxonomic position of ‘Alteromonas thalassomethanolica’ could not be established.
Deposition of DNA-Functionalized Gold Nanospheres into Nanoporous Surfaces (2006)

We report the deposition of DNA-conjugated gold nanospheres into arrays of surface nanopores obtained from hexagonally ordered thin polystyrene-b-poly(methyl methacrylate) (PS-b-PMMA) diblock copolymer films on silicon. The deposition occurs spontaneously from aqueous solution and is driven by either electrostatic interactions or specific DNA hybridization events between the DNA nanospheres and the surface nanopores. To mitigate this spontaneous deposition, we have chemically modified the nanopores with either positively charged aminosilanes or oligonucleotide probe sequences. The deposition of DNA nanospheres into the surface nanopores was characterized by atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). We have observed preferential immobilization of individual DNA nanospheres within the nanopores, based on the size matching between the two entities. The inclusion density and selectivity of DNA nanosphere deposition into the surface nanopores was found to depend predominantly on the methods through which the nanoporous surfaces were prepared and chemically functionalized.
Significance of lipid mediators in shock states. (1989)

Derivatives of fatty acids (e.g., arachidonic acid) and phospholipids (e.g., platelet activating factor) appear to be important mediators of a significant extent of the pathophysiology of circulatory shock. These lipid mediators are extremely potent substances having a variety of important biological effects contributing to cellular injury. Moreover, prevention of either the formation of these lipid mediators by synthesis inhibitors or blockade of their action via specific receptor antagonism improves these shock states. Also, using sensitive chemical and immunological detection methods, increased amounts of these lipid mediators have been identified in body fluids during shock states. Finally, several of these lipid mediators are linked to the activation of other lipid and non-lipid mediators of shock in a manner which amplifies the actions of the lipid mediators.
Therapeutic Potential of Oncolytic Measles Virus: Promises and Challenges (2010)

Measles virus (MV) is a negative-strand RNA virus (paramyxovirus) with oncolytic properties. The significant preclinical activity of MV vaccine strains against a variety of tumor models, their potent bystander effect, their selectivity against tumor cells, and their ability to retain their oncolytic properties when engineered and retargeted makes them a promising oncolytic platform. In this article, we review potential applications and challenges associated with use of MV strains as cancer therapeutics.
Circuit and System Integration (2005)

This chapter contains sections titled: Introduction Analog Frontend Circuitry Building Blocks for CMOS MEMS/NEMS System Integration Example: a Single-Chip Gas-detection System References
A new look at DCT-type transforms (1989)

A computationally efficient DCT- (discrete-cosine-transform) type orthogonal transform obtained by using a construction method developed by W. Kou and H. Zu (1986) is proposed. A recursive relation exists between a higher order and a lower order form of the kernel matrix of the transform and includes the DCT matrices as submatrices. The characteristics of the proposed transform and several fast transform algorithms are discussed. The proposed transform offers a higher computational efficiency than the traditional even discrete cosine transform and yields a mean-squared error close to that of the DCT. Since the HDCT has window spectral structures, it can be used in signal filtering and speech and image processing.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Human Fidgetin is a microtubule severing the enzyme and minus-end depolymerase that regulates mitosis (2012)

Fidgetin is a member of the AAA protein superfamily with important roles in mammalian development. Here we show that human Fidgetin is a potent microtubule severing and depolymerizing the enzyme used to regulate mitotic spindle architecture, dynamics and anaphase A. In vitro, recombinant human Fidgetin severs taxol-stabilized microtubules along their length and promotes depolymerization, primarily from their minus-ends. In cells, human Fidgetin targets to centrosomes, and its depletion with siRNA significantly reduces the velocity of poleward tubulin flux and anaphase A chromatid-to-pole motion. In addition, the loss of Fidgetin induces a microtubule-dependent enlargement of mitotic centrosomes and an increase in the number and length of astral microtubules. Based on these data, we propose that human Fidgetin actively suppresses microtubule growth from and attachment to centrosomes.
Einführung (1982)

Es existiert keine einheitliche Definition des Begriffes Unternehmensführung. Der hier gewählten Betrachtungsweise sind einige Klarstellungen vorwegzuschicken. Zweierlei wird häufig mit dem Begriff Unternehmensführung belegt: Zum einen bezeichnet man als Unternehmensführung eine Institution, und zwar das oberste Organ eines Unternehmens. Dabei wird der Begriff meist synonym zu Unternehmensleitung, Geschäftsführung, Topmanagement gebraucht. Zum anderen versteht man unter Unternehmensführung die Summe bestimmter Aktivitäten. Im folgenden wird der Begriff Unternehmensführung allein in dieser funktionellen Bedeutung verwandt.
Investigation of the capacitance deviation due to metal-fills and the effective interconnect geometry modeling (2004)

In this paper, the influence of floating dummy metal-fills on interconnect parasitic is analyzed with the variations of possible factors which can affect the capacitance. Recently proposed chip-level metal-fill modeling, replacing metal-fill layer with effective high-k dielectric, has been reviewed in detail. Using a systematized modeling flow, the property of the effective permittivity in the modeled geometry is examined. Validation with the realistic 3D structures clearly demonstrates the importance and correctness of the geometry modeling.
Analysis of the dormancy-inducible narK2 promoter in Mycobacterium bovis BCG (2000)

Upon depletion of oxygen, the obligate aerobe mycobacteria switch from growth to a state of non-replicating persistence or dormancy. Here, we report the first functional analysis of a dormancy-dependent mycobacterial promoter in Mycobacterium bovis BCG. Promoter probing using a ′lacZ reporter detected a dormancy-inducible promoter activity upstream of the coding sequence for the putative nitrite extrusion protein NarK2. Primer extension analysis mapped a transcriptional start point 47 bp upstream of the narK2 start codon. Deletion analysis revealed that the sequence −222 to −133 bp upstream from the transcriptional start point was required for basal and dormancy-inducible reporter expression. The sequence +1 to +47 downstream of the transcriptional start point had a strong inhibitory effect on the level of dormancy-induced β-galactosidase activity. The identification of apparent activating and inhibiting regions suggests that the narK2 promoter is at least under dual control.
Organic Acid Profiles in the Juice of Fig Fruits (1996)

To elucidate the organic acid composition and content of fig (Ecus carica L.), a gas chromatography was performed for juices of 20 fig varieties. Acetic, butyric, oxalic, malonic, succinic, fumaric, malic and citric acids were consistently detected throughout fruit growth.
Neutralizing Antibody Responses to Human Immunodeficiency Virus Type 1 in Primary Infection and Long‐Term‐Nonprogressive Infection (1997)

The role of neutralizing antibodies in human immunodeficiency virus type 1 (HIV-1) infection is poorly understood and was assessed by evaluating responses at different stages of infection. Undiluted sera from long-term nonprogressors (LTNP) had broad neutralizing antibodies against heterologous primary isolates and were more likely to neutralize the contemporaneous autologous isolate than were sera from short-term nonprogressors and progressors. In primary infection, envelope-specific IgG was detected before the initial decline in plasma viremia, but neutralizing antibodies developed more slowly. Here, neutralizing antibodies against strains SF-2 and MN were sometimes the first to be detected, but titers were low for at least 17 weeks from onset of symptoms. Neutralizing antibodies against the early autologous isolate were detected for 4 patients by 5-40 weeks but were undetectable in 2 additional patients for 27-45 weeks. The results indicate that neutralizing antibody responses are slow to develop during primary infection and are uniquely broad in LTNP.
Introduction: Coal, Steam and Ships (2018)

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The performance of A.C. systems with predominant power supply by H.V.D.C. inverters (1975)

Model tests are described which have been conducted to investigate the performance of "weak" a.c. systems with d.c. injection. It is shown that system frequency can be controlled effectively by h.v.d.c, inverter stations. Switched capacitors may be used for voltage control. It is shown that power injection into a.c. systems by line commutated h.v.d.c, inverters is possible down to short circuit ratios far below 1.
The MPEG-7 color layout descriptor: a compact image feature description for high-speed image/video segment retrieval (2002)

This paper proposes a color feature description for image and video retrieving applications such as personal video recorder, which manages a large amount of data. This descriptor specifies the spatial distribution of colors with a few nonlinear quantized DCT coefficients of grid based average colors. The tradeoff between the number of the coefficients enclosed in the descriptor and retrieval cost is studied. The experimental results show that the descriptor enclosing six for luminance and three for each chrominance coefficient achieves the best trade-off between the storage cost and retrieval efficiency. It requires 6 bits for DC and 5 bits for AC coefficients, and therefore total storage cost is just 63 bits per image. This description, named color layout descriptor, has been accepted as a part of the MPEG-7 final committee draft.
Resolving the bond angle of a plasmonic metamolecule (2017)

Plasmonic metamolecules have many peculiar properties and have been applied in biological and materials science such as in reconfigurable 3D building blocks for complex nano-architectures and imaging probes for high-resolution sensing. In these applications, fast detection of the bond angles of the sub-wavelength metamolecules is highly desired. However, angle detection is not the same as orientation detection. The two orientations must be determined simultaneously, and common orientation sensors can only measure one. In this work, we propose and demonstrate a method to resolve the bond angle of a plasmonic metamolecule composed of three spherical nanoparticles. The detection of the bond angle is achieved via modulation depth analysis of polarization-resolved dark-field images. The underlying mechanism is found to be the opposing responses of the longitudinal and transversal bonding modes to the polarization variation of the incident light. In addition, the spectrally degenerate structures are further distinguished by the spot center localization method. This method may pave the way for practical application of plasmonic metamolecules.
Practical display-camera calibration from eye reflections using coded illumination (2011)

Display-camera systems enable a large range of vision applications in everyday environments, but require calibrating the pose of the display with respect to the camera. Recently, a promising approach is introduced that analyzes corneal reflections from face images. While having several benefits, the described implementation requires controlled and unnatural conditions, manual elaboration, and offline processing. This work aims to improve the approach and allow for conditions of practice: First, the novel idea is proposed to encode display correspondences into illumination patterns to enable automatic and robust detection. This comprises the first use of coded illumination with corneal reflection analysis. Second, since previous evaluation revealed a large error for the basic algorithm, this work discusses thorough experimental evaluation of an optimization strategy based on geometry constraints in the scene. Results show that considerable improvement can be achieved under common parameter variation, which successfully verifies the feasibility of the approach.
An inductive wireless charger for electric vehicle by using LLC resonance with matrix ferrite core group (2015)

A wireless LLC charger using primary-side resonance to achieve magnetic inductive coupling with matrix core set (MCS) is proposed for power transfer to electric vehicle. The MCS consists of usual low cost ferrite core in matrix form, including transmitter MCS (TX MCS) and receiver MCS (RX MCS), in which both two MCSs are expected to be coupling close in proximity. Although the leakage inductance may result in inevitable poor coupling between TX MCS and RX MCS, the LLC resonator can effectively absorb it to be a resonant element to eliminate harmonic noise. In order to facilitates analysis, a transconductance G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> (jω) instead of the usual voltage gain G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">v</sub> (jω) is presented to clearly describe the LLC behavior that can be depicted by load trace continuous in or between Region 1 and Region 2 of DC characteristics without interruption. In addition, the modeling of TX-RX transformer with MCS is conducted for the analysis of LLC resonance to power transfer. Finally, a scale-down 450-W wireless LLC charger for a 24-V battery in electric vehicle is experimented to assess the described the power transfer behavior. The experimental results successfully achieve nearly 90% resonant power transfer and meet the expected performance for feasibility.
Podocalyxin Increases the Aggressive Phenotype of Breast and Prostate Cancer Cells <i>In vitro</i> through Its Interaction with Ezrin (2007)

Podocalyxin is an anti-adhesive transmembrane sialomucin that has been implicated in the development of more aggressive forms of breast and prostate cancer. The mechanism through which podocalyxin increases cancer aggressiveness remains poorly understood but may involve the interaction of podocalyxin with ezrin, an established mediator of metastasis. Here, we show that overexpression of podocalyxin in MCF7 breast cancer and PC3 prostate cancer cell lines increased their in vitro invasive and migratory potential and led to increased expression of matrix metalloproteases 1 and 9 (MMP1 and MMP9). Podocalyxin expression also led to an increase in mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) activity. To determine the role of ezrin in these podocalyxin-dependent phenotypic events, we first confirmed that podocalyxin formed a complex with ezrin in MCF7 and PC3 cells. Furthermore, expression of podocalyxin was associated with a changed ezrin subcellular localization and increased ezrin phosphorylation. Transient knockdown of ezrin protein abrogated MAPK and PI3K signaling as well as MMP expression and invasiveness in cancer cells overexpressing podocalyxin. These findings suggest that podocalyxin leads to increased in vitro migration and invasion, increased MMP expression, and increased activation of MAPK and PI3K activity in MCF7 and PC3 cells through its ability to form a complex with ezrin.
An Ecological-Physiological Study of Moose (1963)

An ecological-physiological study of the Shiras moose population in the Jackson Hole area was initiated in August of 1963. Moose population dynamics will be one phase of the study, and will involve calculations of population productivity, sex and age structure of the population, and factors regulating population numbers and success. Measurements of physiological condition of the population as related to forage conditions, sex and age, and behavior will be attempted. Other phases of the study involve moose-habitat relationships and spatial distribution and mobility of the population. Project Number 125.