gebhart/patrepeval huggingface dataset:
Interactions between Buprenorphine and Antiretrovirals. I. The Nonnucleoside Reverse-Transcriptase Inhibitors Efavirenz and Delavirdine (2006)

This study examined drug interactions between buprenorphine, an opioid partial agonist medication used in the treatment of opioid dependence, and the nonnucleoside reverse-transcriptase inhibitors (NNRTIs) efavirenz (EFV) and delavirdine (DLV). Opioid-dependent, buprenorphine/naloxone-maintained, human immunodeficiency virus (HIV)-negative volunteers (n=10 per NNRTI) participated in 24-h sessions to determine pharmacokinetics of buprenorphine and of buprenorphine with either EFV or DLV after administration of standard doses of either antiretroviral for 15 or 7 days, respectively. Opiate withdrawal symptoms, cognitive effects, and adverse events were determined before and after antiretroviral administration in opioid-dependent participants. The pharmacokinetics of NNRTIs in healthy control participants were used to determine the effect of buprenorphine on NNRTIs. EFV decreased the buprenorphine area under the concentration-time curve (P<.001). DLV increased buprenorphine concentrations (P<.001). Clinically significant consequences of these interactions were not observed. Buprenorphine did not alter antiretroviral pharmacokinetics. Adjustments of doses of either buprenorphine or EFV or DLV are not likely to be necessary when these drugs are administered for the treatment of opiate dependence and HIV disease.
<i>In silico</i> predictability of allergenicity: From amino acid sequence<i> via</i> 3‐D structure to allergenicity (2006)

In relation to the prediction of allergenicity three aspects have to be discussed: IgE immunogenicity, IgE cross-reactivity, and T-cell cross-reactivity. IgE immunogenicity depends largely on factors other than the protein itself: the context and dose and "history" of the protein by the time it reaches the immune system. It is, therefore, not fully predictable from structural information. In contrast, IgE cross-reactivity can be much more reliably assessed by in-silico homology searches in combination with in vitro IgE antibody assays. The in-silico homology search is unlikely to miss potential cross-reactivity with sequenced allergens. So far, no biologically relevant cross-reactivity at the antibody level has been demonstrated between proteins without easily demonstrable homology. T-cell cross-reactivity is much more difficult to predict than B-cell cross-reactivity. Moreover, its effects are more diverse. Yet, pre-existing cross-reactive T-cell activity is likely to influence the outcome not only of the immune response, but also of the effect phase of the allergic reaction. The question of whether any antigen can be allergenic is still a matter of debate.
Near-Field Phase Change Optical Recording Using a GaP Hemispherical Lens (2000)

A GaP solid immersion lens and a modified liquid immersion lens (MLIL) are studied. The phase change marks exhibit a diameter of approximately 200 nm when recorded by the MLIL.
Finite impulse response-filter-based RF-beamforming network for wideband and ultra-wideband antenna arrays (2011)

In this study, a wideband electronic beamforming concept applicable for ultra-wideband short pulse systems is derived and experimentally demonstrated. In particular, a finite impulse response (FIR)-filter-based beamforming network is configured such that an antenna array yields a desired radiation pattern within a predefined frequency range. An experimental verification of a wideband transmission system is presented for the frequency range from 1.5 to 2.0 GHz. The transmit system consists of a wideband power divider feeding a matrix of analogue FIR-filters. These FIR-filters control a circular antenna array of four elements. The receiver consists of a single antenna element. Measurements are performed in frequency domain using a vector network analyser. The results show an almost frequency independent radiation pattern with a half power beamwidth of 72° and a maximum sidelobe level of −10 dB.
Light Color Attraction and Dietary Sugar Composition for Several Mosquito (Diptera: Culicidae) Species Found in North Central Florida (1998)

Abstract : The behavioral response of mosquitoes to different wavelengths of light and an evaluation of sugar meals was studied for several species of mosquito found in north central Florida. Gas chromatography (GC) was used to analyze dietary sugars of Anopheles quadrimaculatus, Coquillettidia perturbans Culex nigripalpus, Culiseta melanura and Psorophora ferox. GC was also used to determined whether carbohydrases are present in the mosquito diverticula. A wide range of sugars was found in wild mosquitoes including fructose, glucose, sucrose, maltose, turanose, melezitose, raffinose, erlose, arabinose, rhamnose, and several unknowns. Laboratory time course studies with Aedes albopictus showed rapid hydrolysis of sucrose within 2 hours of ingestion. Conversely, melezitose remained relatively unchanged after 8 hours. The frequency of wild mosquitoes containing sugars ranged from 10-11% in An. quadrimaculatus and Ps. ferox to 48% in Cq. perturbans. All species tested contained honeydew sugars including An. quadrimaculatus (55%), Cs. melanura (33%), Cx. nigripalpus (15%) Cq. perturbans (10%) and Ps. ferox (7%). Light trap capture numbers for woodland mosquitoes were evaluated using light emitting diodes (LEDs) of different colors. Analysis of data by species showed significant differences in color attraction (green and blue best) for Ae. atlanticus, Ae. dupreei, Ae. infirmatus, An. crucians, Cs. melanura, Cx. nigripalpus, Ps. columbiae and Uranotaenia sapphirina. Attraction was also evaluated using different orientations (light reflected of off lid, or 3600 radius) of green/blue LEDs and found significant capture number differences for only Am crucians, Cs. melanura, Cx. (Melanoconion spp.) and Ur. sapphirina. In the lab, a ten port visualometer was constructed to evaluate the feeding response of 4 mosquito species over various wavelengths of light.
Identification of Human microRNA Targets From Isolated Argonaute Protein Complexes (2007)

MicroRNAs (miRNAs) constitute a class of small non-coding RNAs that regulate gene expression on the level of translation and/or mRNA stability. Mammalian miRNAs associate with members of the Argonaute (Ago) protein family and bind to partially complementary sequences in the 3' untranslated region (UTR) of specific target mRNAs. Computer algorithms based on factors such as free binding energy or sequence conservation have been used to predict miRNA target mRNAs. Based on such predictions, up to one third of all mammalian mRNAs seem to be under miRNA regulation. However, due to the low degree of complementarity between the miRNA and its target, such computer programs are often imprecise and therefore not very reliable. Here we report the first biochemical identification approach of miRNA targets from human cells. Using highly specific monoclonal antibodies against members of the Ago protein family, we co-immunoprecipitate Ago-bound mRNAs and identify them by cloning. Interestingly, most of the identified targets are also predicted by different computer programs. Moreover, we randomly analyzed six different target candidates and were able to experimentally validate five as miRNA targets. Our data clearly indicate that miRNA targets can be experimentally identified from Ago complexes and therefore provide a new tool to directly analyze miRNA function.
Fetal liver cell transplantation in scid mice. (1990)

Mice with severe combined immunodeficiency (CB 17 scid) received isogeneic and allogeneic fetal liver cell transplantation. Immunological reconstitution was followed by immunoglobulin production, mitogen-induced proliferation, spleen and thymus lymphoid recolonization. Scid mice injected with isogeneic fetal liver cells showed normal IgM, IgG production and subnormal Con-A induced proliferation. Lymphoid organs were gradually repopulated. Mice having received allogeneic stem cells presented normal IgM and IgG secretion. They still had no mitogen-induced lymphocyte stimulation, two months after fetal cell transplantation, despite satisfactory repopulation of spleen and thymus. Reconstitution of cell-mediated immunity may be somewhat slower following allogeneic than isogeneic stem cell transplantation.
Biochemical Changes and Sensory Quality of Shredded and MA‐Packaged Iceberg Lettuce (1995)

ABSTRACT Cultivars of shredded iceberg lettuce ( Lactuca sativu L.) ‘Saladin’, ‘Santis’, ‘Telda’ and ‘Roxette’ responded in a parallel way to four modified atmosphere (MA) packaging treatments. Moderate vacuum packaging (mvp) in 80 μm polyethylene (PE) inhibited enzymatic browning over 10‐day storage at 5°C. When lettuce was packaged in 80% O 2 , 20% CO 2 (80/20), more browning occured in SL3‐bags (59 μm multilayer coextruded film) than in PE‐bags. Polyphenol oxidase activity declined during storage in all 4 atmospheres, with lowest activity in PE‐80/20. Endogenous ascorbic acid (AA) did not act as an efficient antioxidant in delaying browning. Total carbohydrate content (TC) declined slightly during storage. Tristimulus color measurements correlated highly with visual ratings.
Facile Synthesis and Biological Evaluation of Novel Symmetrical Biphenyls as Antitumor Agents (2012)

As a continuation to our previous work in developing anticancer agents, eighteen symmetrical biphenyl derivatives structurally related to taspine were synthesized and evaluated in vitro and in vivo. All the compounds were prepared with varied substitutions in the phenyl ring of aniline moiety. The cytotoxicity and anticancer activity of biphenyls was evaluated against various human tumor and normal cell line. Antiproliferative assays indicated that some of them exhibited potent anticancer activity. The potent antiproliferative activity of these compounds against ECV304 suggested that these biphenyls could be served as antiangiogenic agents. The highly active compound (2) also exhibited potent growth inhibition against cancer cell lines in vivo. Our findings demonstrated that these symmetrical biphenyl derivatives would be a promising candidate as novel anticancer agents.
User and Device Tracking in Private Networks by Correlating Logs: A System for Responsive Forensic Analysis (2014)

IP address of a device, from where an offending activity was performed, is of limited value, because it does not specify a physical device/user, but an endpoint in network. It is useful to have information about where a device/user was at the time the offending activity was performed. It would be desirable to correlate different pieces of evidence to discover information, such as IP addresses used by the same device, physical address and location of the device, connection time of the device, browsing habits and mail access transactions carried out by the user using the device. Log data from various sources are required to be correlated together to create contexts of information, which is not visible from one source alone. In large networks, users/devices accessing a private network repeatedly can be tracked by analyzing and correlating DHCP, Network Access Control, WWW, Email server logs. With huge amount of logs, the common approach of manual browsing, correlating of log events, based on timelines is tedious, unresponsive approach. Flat file based sequential search system is not responsive, hence RDBMS based tracking systems are desirable. To build a responsive system requires identifying, consolidating log files, conversion, transmission and storage into relational databases. An automated system has been developed at our organization for forensic analysis of network accesses, with device and user tracking as its goal. We present, our approach to perform log management, correlation, which assists in performing responsive forensic analysis of real network with more than 2500 nodes, aimed at tracking users/devices.
Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period (2011)

Reactive oxygen species (ROS) play a critical role in the pathogenesis of various diseases during pregnancy and the perinatal period. Newborns are more prone to oxidative stress than individuals later in life. During pregnancy, increased oxygen demand augments the rate of production of ROS and women, even during normal pregnancies, experience elevated oxidative stress compared with non-pregnant women. ROS generation is also increased in the placenta during preeclampsia. Melatonin is a highly effective direct free-radical scavenger, indirect antioxidant, and cytoprotective agent in human pregnancy and it appears to be essential for successful pregnancy. This suggests a role for melatonin in human reproduction and in neonatal pathologies (asphyxia, respiratory distress syndrome, sepsis, etc.). This review summarizes current knowledge concerning the role for melatonin in human pregnancy and in the newborn. Numerous studies agree that short-term melatonin therapy is highly effective in reducing complications during pregnancy and in the neonatal period. No significant toxicity or treatment-related side effects with long-term melatonin therapy in children and adults have been reported. Treatment with melatonin might result in a wide range of health benefits, including improved quality of life and reduced healthcare costs.
Assessment of Ambipolar Behavior of a Tunnel FET and Influence of Structural Modifications (2012)

In the present work, comprehensive investigation of the ambipolar characteristics of two silicon (Si) tunnel field-effect transistor (TFET) architectures (i.e. p-i-n and p-n-p-n) has been carried out. The impact of architectural modifications such as heterogeneous gate (HG) dielectric, gate drain underlap (GDU) and asymmetric source/drain doping on the ambipolar behavior is quantified in terms of physical parameters proposed for ambipolarity characterization. Moreover, the impact on the miller capacitance is also taken into consideration since ambipolarity is directly related to reliable logic circuit operation and miller capacitance is related to circuit performance.
Motor Skill Training, but not Voluntary Exercise, Improves Skilled Reaching After Unilateral Ischemic Lesions of the Sensorimotor Cortex in Rats (2007)

In young and middle-aged animals, exercise did not improve motor skill training efficacy following ischemic lesions. Practicing motor skills more effectively improved recovery of these skills than did exercise. It remains possible that an alternative manner of administering exercise would be more effective.
Abendländische und fernöstliche Medizin: Alte Gegensätze — neue Brücken (2000)

Nach dem Zerfall des Römischen Reiches und entsprechend der Ausdehnung des Machtbereiches der Kaiser und Päpste versiegten mit dem Rückzug der Araber von der Iberischen Halbinsel für das Abendland die Quellen des medizinischen Wissens — auch aus Asien die den Griechen und Römern durch den Handelsverkehr und Wissensaustausch über die „Seidenstraße“ noch zugänglich gewesen waren. Daran vermochten selbst Ausnahmeerscheinungen wie Friedrich II von Sizilien — „Stupor mundi“ — nichts Prinzipielles zu ändern. Dazu kam, dass selbst das rudimentäre Wissen, das in die Volksmedizin eingegangen und von „weisen Frauen“ von Generation zu Generation weitergereicht worden war, in der Zeit der Inquisition und der Hexenprozesse Schutz suchend in den „Nebeln von Avalon“ untertauchte.
A hierarchical floor-planning, placement, and routing tool for sea-of-gates designs (1989)

The authors present an automatic layout system for designing large sea-of-gates gate arrays. This tool combines a floorplanning tool with an automatic placement and routing tool. It is designed to handle 250 K-gate arrays with special functional blocks such as RAM and ROM. It provides features for current processing, timing-driven layout, special clock distribution, and power distribution. The tool is currently being tested for designing the industry's most complex sea-of-gates gate arrays
Optical Sensing: A New Approach to Measurements with Fiber Bragg Gratings (2010)

Optical sensors have emerged during the telecom boom in the late 1900's, due to the availability to lowcost telecomgrade optical components. It's only after the telecom bubble in early 2000 that optical sensors became sufficiently developed to become a viable technology for realworld civionics applications. Optical sensing systems are nonconducting and use light to perform measurements of various phenomena. There are a few optical sensor technologies available, each with different strengths and weaknesses. FBGbased optical sensing provides distinct advantages for civil measurements because of their multiplexing capability and wavelengthencoded measurement information. In other words, with their ability to serve both as sensing element and signal transmission medium, FBG technology can have a significant impact on the health and efficiency of civil infrastructure systems. This paper will present a holistic view of stress/strain measurements, including conventional strain gages and vibrating wires. It will then introduce optical sensing, presenting the different optical sensor technologies. Finally, more details on FBG optical sensing will be provided, including the benefits that make FBG a compelling technology for civionics applications.
Spatiotemporal control of cell–cell reversible interactions using molecular engineering (2016)

Manipulation of cell-cell interactions has potential applications in basic research and cell-based therapy. Herein, using a combination of metabolic glycan labelling and bio-orthogonal click reaction, we engineer cell membranes with β-cyclodextrin and subsequently manipulate cell behaviours via photo-responsive host-guest recognition. With this methodology, we demonstrate reversible manipulation of cell assembly and disassembly. The method enables light-controllable reversible assembly of cell-cell adhesion, in contrast with previously reported irreversible effects, in which altered structure could not be reused. We also illustrate the utility of the method by designing a cell-based therapy. Peripheral blood mononuclear cells modified with aptamer are effectively redirected towards target cells, resulting in enhanced cell apoptosis. Our approach allows precise control of reversible cell-cell interactions and we expect that it will promote further developments of cell-based therapy.
All-optical address recognition and self-routingin a 250 Gbit/s packet-switched network (1994)

The authors report the first demonstration of all-optical address recognition and self-routing of photonic packets for the case where the packet bit period is only 4 ps, corresponding to a 0.25 Tbit/s bandwidth optical network. An ultrafast all-optical device, known as a terahertz optical asymmetric demultiplexer (TOAD), was used to read the address information encoded in a packet header, which in turn was used to route the packet. The bit error rate at the switch output was measured to be less than 10-9.
Time-Sensitive Bayesian Information Aggregation for Crowdsourcing Systems (2016)

Many aspects of the design of efficient crowdsourcing processes, such as defining workers bonuses, fair prices and time limits of the tasks, involve knowledge of the likely duration of the task at hand. In this work we introduce a new timesensitive Bayesian aggregation method that simultaneously estimates a tasks duration and obtains reliable aggregations of crowdsourced judgments. Our method, called BCCTime, uses latent variables to represent the uncertainty about the workers completion time, the tasks duration and the workers accuracy. To relate the quality of a judgment to the time a worker spends on a task, our model assumes that each task is completed within a latent time window within which all workers with a propensity to genuinely attempt the labelling task (i.e., no spammers) are expected to submit their judgments. In contrast, workers with a lower propensity to valid labelling, such as spammers, bots or lazy labellers, are assumed to perform tasks considerably faster or slower than the time required by normal workers. Specifically, we use efficient message-passing Bayesian inference to learn approximate posterior probabilities of (i) the confusion matrix of each worker, (ii) the propensity to valid labelling of each worker, (iii) the unbiased duration of each task and (iv) the true label of each task. Using two real- world public datasets for entity linking tasks, we show that BCCTime produces up to 11% more accurate classifications and up to 100% more informative estimates of a tasks duration compared to stateoftheart methods.
Gates of Enzymes (2013)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTGates of EnzymesArtur Gora†, Jan Brezovsky†, and Jiri Damborsky*†‡View Author Information† Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment, Faculty of Science, Masaryk University, Kamenice 5/A13, 625 00 Brno, Czech Republic‡ International Centre for Clinical Research, St. Anne's University Hospital Brno, Pekarska 53, 656 91 Brno, Czech Republic*Phone +420-5-49493467. Fax +420-5-49496302. E-mail: [email protected]Cite this: Chem. Rev. 2013, 113, 8, 5871–5923Publication Date (Web):April 25, 2013Publication History Received17 September 2012Published online25 April 2013Published inissue 14 August 2013https://doi.org/10.1021/cr300384wCopyright © 2013 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views10402Altmetric-Citations176LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (65 MB) Get e-AlertsSUBJECTS:Cavities,Conformation,Genetics,Peptides and proteins,Protein structure Get e-Alerts