gebhart/patrepeval huggingface dataset:
Reconfigurable control and fault identification system (2005)

The integration of health management and reconfigurable flight control is demonstrated in the NAVAIR/Boeing Reconfigurable Control and Fault Identification System (RCF1S) Dual Use Science and Technology program (Contract N00421-003-0123). The major research results include: 1) expansion of diagnostic capability by detecting levels of actuator degradation that can be used to reduce could not duplicates and false alarms in the current BIT systems, 2) fusion of system and component level health assessment results, 3) the ability to perform structured tests of control system actuator components during flight when loads and temperature environment are present to enable a more accurate health assessment with no impact on the flight trajectory or ride quality, 4) modification of actuator controls in order to make the best use of the degraded actuator remaining capabilities and/or extend the life of the component and 5) modification of system level controls to compensate for the degraded component/subsystem capability or damage.
Chemical Synthesis and Structural Study of Lincomycin Sulfoxides and a Sulfone. (1997)

Oxidation of lincomycin with dimethyldioxirane resulted in the sulfoxide-glycosides 3a and 3b, whose treatment with osmium tetraoxide and N-methylmorpholine-N-oxide afforded the same sulfone; 4. According to FAB-MS and CD investigations, the absolute configuration of the sulfur atom in 3a and 3b is R and S, respectively. The new, unsaturated antibiotic analog (6) derived from clindamycin exists in the 4C1 conformation. The antibiotic activities of the synthesized compounds were also studied.
Copyrights and Copyremedies: Unfair Use and Injunctions (1989)

The author has observed
Contrôle et traitement des eaux et des effluents par techniques UV (2001)

L'usage de sources UV dans les technologies environnementales est particulirement rpandu pour le contrle de la qualit des eaux et des effluents et leur traitement. Dans les deux cas, le domaine couvert est de 180 350 nm et les lampes utilises, trs classiques, sont du type Hg basse pression ou deutrium. Diffrentes applications sont prsentes comme la mesure de la qualit des milieux (spectrophotomtrie directe ou indirecte) ou le traitement par procds de photooxydation avance.
Photosynthetic activity of cyanobacteria in water‐in‐oil microemulsions (1992)

The solubilization and the photosynthetic activity of cyanobacteria (Anabaena variabilis) in water-in-oil microemulsions consisting of (Tween85/Span80)/hexadecane/water is investigated. Transparent and stable solutions containing up to 10(8) cells/mL could be obtained. The physical state and stability of the cells in the microemulsion, as evidenced from optical and electron microscopy, is dependent upon the physical parameters of the system, and in particular on the hydrophilic-lypophilic balance (HLB) of the surfactant system. Conditions could be found, under which the cells in the microemulsion system display photosynthetic activity This was judged by measuring polarographically the oxygen evolution and by studying the photosynthetic activity in the presence of specific inhibitors.
Controlling conjugated polymer morphology and charge carrier transport with a flexible-linker approach (2014)

The Stille-coupling polymerization of a short conjugated polymer with an aliphatic linker was used to demonstrate a prototype in a new class of polymer semiconductors wherein the conjugation segment length and the length of the entire chain can be independently controlled. Subsequent thermal, morphological, and 2D grazing-incidence crystallographic analysis revealed this prototype polymer's ability to exhibit distinct thin-film morphologies without changing the molecular weight. In field-effect transistors this unique ability gave rise to an improvement of the charge carrier mobility from fibril-type (0.01 cm2 V−1 s−1) to terrace morphologies (0.04 cm2 V−1 s−1). When compared to a fully-conjugated, high molecular weight polymer, these differences afforded insight into the roles of inter- and intra-molecular charge transport in the film, highlighting the importance of chain self-assembly on charge transport. Overall, our results indicate that employing linkers is a promising route to advance morphology control in semiconducting polymer based devices.
Challenges of Capturing Natural Web-Based User Behaviors (2008)

It can be difficult to properly understand aspects of user behavior on the Web without examining the behaviors in a realistic setting, such as through field studies. In this article, an overview of the experiences in augmenting logged data with contextual information over the course of two separate research projects conducted in the field is presented. One project investigated the privacy sensitivity of normal Web browsing, and the other examined user behavior during Web-based information-seeking tasks. Throughout both projects, the contextual information was collected through participant annotations of their Web usage. Based on experiences in conducting this research, implications of methodological decisions are considered, unanswered questions are highlighted, and considerations for other researchers are provided. These shared experiences and perspectives will assist future researchers planning similar field studies, allowing them to build upon the lessons learned.
Optical analog of the permeability of sandstones (1992)

We demonstrate a correlation between the transmissivity of sandstones to visible light and their fluid permeability. By means of experiments carried out on sandstone and sand packs, we show that the light transmission increases when the contrast between the indices of refraction of the matrix material and pore-filling fluid is reduced, and that, for a given fluid, it is greatest for rocks with the largest grains. We present qualitative and analytical arguments, and results of a numerical simulation, which account for these correlations. The simulations also yield the space and time distribution of the transmitted light. Finally, we show that light transmission provides a method of mapping the permeability of sandstone without fluid flow, and at high spatial resolutions. Extension of these findings to rocks other than sandstones is discussed.
Electrostatic scanning micromirrors using localized plastic deformation of silicon (2005)

Electrostatic scanning micromirrors made of single-crystal silicon from a SOI (silicon-on-insulator) wafer using self-aligned and localized plastic deformation of silicon have been demonstrated. Localized plastic deformation is achieved by selective Joule heating of silicon structures while the whole substrate is kept at low temperature. Novel designs for torsional springs to prevent the buckling problem due to the non-uniform thermal expansion by localized heating are presented and the optimal range of electric power for successful Joule heating is discussed. The prototype micromirror is actuated by self-aligned vertical comb sets at a measured resonant frequency of 4.13 kHz with optical scanning angles up to 50.9° under driving voltages of 30 Vdc plus 14 Vac. After continuous operation of 20 billion cycles (56 days) at the maximum scanning angle, the device shows no observable signs of degradation or fatigue.
Serum-free media for the growth of primary bovine myoblasts (2019)

The demand for meat is expected to exceed production capacity by livestock in the coming decennia. Therefore, cultured beef might be a viable alternative to traditional livestock-derived beef. One of the problems however is the sustainability of cultured beef through the use of fetal bovine serum. We aimed to identify a serum-free medium or a serum-replacement that is as effective as the current method used for culturing bovine myoblasts. Cells were harvested from a female Blanc Bleu Belge cow and myoblasts were subsequently isolated. Cells were cultured in either Advanced DMEM containing 20% FBS and 10% HS or one of the chemically-defined, serum-free media for 6 days. MTS was used as a measure of cell proliferation at day 1, 4 or 6 and microscopic pictures were taken to assess cell morphology. FBM™, TesR™ and Essential 8™ are commercially available xeno-free media developed for human PSCs and fibroblasts, with the highest potential to sustain bovine myoblast proliferation. Of the supplements tested, XenoFree™ and a custom-prepared growth factor mix failed to stimulate cell proliferation. LipoGro™ stimulated cell proliferation in some cases but also changed the phenotype of myoblasts to an adipocyte-like phenotype. We conclude that serum-free media stimulate exponential cell expansion, albeit not to the extent of the current growth medium containing up to 30% serum. Further research is needed to investigate whether prolonged cell culture or an adaptation period could further increase cell proliferation.
Radiative and other effects from internal waves in solar and stellar interiors (1981)

Starting from the usual spherical mode and planar Boussinesq formulations, equations are derived for the propagation and dissipation of internal gravity waves in a stellar interior. The sun is 'transparent' to such waves if they have sufficiently low mode number (less than 10) and high frequency (more than 10 times the convective overturn frequency). Even when spatially and temporally incoherent, such waves focus toward the center of the sun, so that their amplitude greatly increases there. An order of magnitude estimate suggests that the internal waves generated at the base of the convective zone may become nonlinear in amplitude close to the solar center. If this happens, several effects become important and can affect, e.g., the expected Cl-37 solar neutrino signature. Possible effects include (1) hydraulically enhanced diffusion of entropy, which can increase the effective radiative opacity of the solar material by a factor of order unity, and (2) wave-induced turbulence, which can lead to species mixing.
Intensity-Based Statistical Scorer for Tandem Mass Spectrometry (2003)

We describe a new statistical scorer for tandem mass spectrometry. The scorer is based on the probability that fragments with given chemical properties create measured intensity levels in the experimental spectrum. The scorer's parameters are computed using a fully automated procedure. Benchmarking the new scorer on a large set of experimental spectra, we show that it performs significantly better than the widely used cross-correlation scoring algorithm of Eng et al. (Eng, J. K; McKormack, A. L.; Yates, J. R. J. Am. Soc. Mass Spectrom. 1994, 5, 976-989.).
New optimized agglomerative clustering algorithm using multilevel threshold for finding optimum number of clusters on large data set (2012)

The traditional hierarchical clustering methodswhich are suitable to categorize the large dataset but do not produce effective partitions result, because of their high computational complexity, higher number of iterations and more misclassification errors. To overcome this, in this paper, a new technique called Optimized Agglomerative Clustering(OAC)is proposed for effective clustering and pattern classification of large data set, and we also introduced three new threshold methods that can find optimal merge cost for limit the number of iterations. The proposed OAC technique is work with three new thresholds that aims to automatically produce optimum number of clusters with good accuracy, and it reduces computational complexity, numbers of iterations and misclassification errors. Experimental results show that the proposed technique OAC produces a better clustering result with high accuracy than traditional techniques.
Effect of Dapagliflozin on Heart Failure and Mortality in Type 2 Diabetes Mellitus (2019)

URL: https://www.clinicaltrials.gov . Unique identifier: NCT01730534.
"Augeye" a compact, solid Schmidt optical relay for helmet mounted displays (2002)

The optical design, fabrication and performance of a solid Schmidt prism used for relaying an optical signal or image to the eye while simultaneously providing the viewer with the capability to see-through to the outside world is described. It can be either of solid glass or plastic construction like a prism, or made of separate components. The novel aspect of this approach over previous designs is folding the system between the image and the Schmidt mirror as opposed to folding it at the image itself. This allows for a more compact design. The solid glass approach extends the apparent field of view to the viewer through refraction at the glass to air interface. If the spherical reflector of the Schmidt is rendered opaque, the viewer will only see the information provided by the optical stimulus. If partially reflective, the viewer can augment real world scenes with computerized symbology superimposed in the visual field. The stimulus may be either a high resolution CRT or a flat panel liquid crystal display (LCD).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Recent Developments in Novel Pyrrolo[2,1-c][1,4]Benzodiazepine Conjugates: Synthesis and Biological Evaluation (2003)

The biological activity of many low molecular weight antitumor compounds appear to be related to their mode and specificity of interaction with particular DNA sequences. Such small molecules are of considerable interest in chemistry, biology and medicine. Most of the anticancer drugs employed clinically exert their antitumor effect by inhibiting nucleic acid (DNA or RNA) or protein synthesis. Inhibition can occur for example through cross-linking of bases in DNA or binding to and inactivation of enzymes necessary for the synthetic processes. It is evident that DNA is an important cellular target for many anticancer agents. Much information has been obtained from molecular genetics, i.e. replication of DNA and its transcription to RNA, which provides the template for protein synthesis. DNA is a well-characterized intracellular target but its large size and sequential nature makes it an elusive target for selective drug action. Binding of low molecular weight ligands to DNA causes a wide variety of potential biological responses. In this context PBDs (pyrrolo[2,1-c][1,4]benzodiazepines), a group of potent naturally occurring antitumor antibiotics produced by various Streptomyces species, are one of the most promising types of lead compounds. They differ in the number, type and position of substituent in both their aromatic A-ring and Py C-rings, and in the degree of saturation of the C-rings which can be either fully saturated or unsaturated at either C2-C3 (endocyclic) or C2 (exocyclic). There is either an imine or carbinolamine methyl ether at the N10-C11 position. This latter is an electrophilic center responsible for alkylating DNA. In the search for compounds with better antitumor selectivity and DNA sequence specificity many PBD analogues have been synthesized in an attempt to increase their potency against tumor cells. We review here recent progress on pyrrolo[2,1-c][1,4]benzodiazepine (PBDs) analogues and their conjugates, also the progress and developments of PBD conjugates with polyamides (information reading molecules in the minor groove of DNA). For example, the cross-linking efficiency of PBD dimers is much greater than that of other cross linkers including cisplatin and melphalan. A large number of PBD dimers and polyamide conjugates with varying linker lengths and bearing different heterocycles at different positions in the PBD ring synthesized in our group and their pharmacological properties have been reviewed.
[State of pulmonary metabolism during radiotherapy of thoracic neoformations and possibilities of its correction]. (1999)

Administration of Ural licorice extract seems promising for prevention of radiation complications in the lungs during radiotherapy to the chest area.
Distributed Event Detection in Wireless Sensor Networks for Forest Fires (2013)

As the technology is advancing, Wireless Sensor Networks (WSN) is a gaining importance in recent research areas as it has proved its usefulness in warning disasters and save lives and assets. When an unusual event is noticed in the networks, an event is detected through the sensor devices placed at distributed locations. This event detection information is passed to the base station and intelligent decision is taken. Various machine learning techniques are used to decide whether the event has occurred or not. In this paper, we proposed an ensemble distributed machine learning approach for detecting events. This approach works in two phases, base phase and meta phase, clustream and Support Vector Machine approach are used for detection and prediction of events. One hop tree is used in this approach in order to minimize the delay in transmitting information.
Oral delivery of tumor‐targeting <i>Salmonella</i> exhibits promising therapeutic efficacy and low toxicity (2009)

Tumor-targeting bacteria have been developed as powerful anticancer agents. Salmonella typhimurium VNP20009, a representative tumor-targeting strain, has been systemically administered as a single-agent therapy at doses of 1 x 10(6) to 3 x 10(6) colony-forming unit (cfu)/mouse, or in combination with other antitumor agents at doses of 1 x 10(4) to 2 x 10(5) cfu/mouse. Recently, we reported that oral delivery of VNP20009 at the dose of 1 x 10(9) cfu/mouse induced significant anticancer effects comparable to that induced by systemic administration of this strain at 1 x 10(4) cfu/mouse. To further address the efficacy and safety of oral administration of bacteria, here we performed a systemically comparative analysis of anticancer efficacy and toxicity of VNP20009 administered: (i) orally at a dose of 1 x 10(9) cfu/mouse (VNP9-oral); (ii) intraperitoneally at a dose of 1 x 10(4) cfu/mouse (VNP4-i.p.); or (iii) intraperitoneally at a dose of 1 x 10(6) cfu/mouse in tumor-free and tumor-bearing murine models. The results showed that VNP9-oral, similar to VNP4-i.p., induced significant tumor growth inhibition whereas VNP6-i.p. induced better anticancer effect in the B16F10 melanoma model. Among three treatments, VNP9-oral induced the mildest and reversible toxicity whereas VNP6-i.p. resulted in the most serious and irreversible toxicities when compared to other two treatments. Moreover, the combination of VNP9-oral with a low dose of chemotherapeutics produced comparable antitumor effects but displayed significantly reduced toxicity when compared to VNP6-i.p. The findings demonstrated that oral administration, as a novel avenue in the application of bacteria, is highly safe and effective. Moreover, the present preclinical study should facilitate the optimization of bacterial therapies with improved anticancer efficacy and reduced adverse effects in future clinical trials.
Circular magnetic macroparticle accelerator for impact fusion (1990)

The author proposes the use of a circular accelerator for gram-size superconducting macroparticles, with the acceleration to the velocities needed for impact fusion performed by a magnetic travelling wave. It is suggested to use the recently discovered high-Tc superconductors both for the macroparticle and for the establishment of the waveguide field. To give the macroparticle a large magnetic moment, it is proposed that it be composed of a densely packed lattice of superconducting grains embedded in a suitable insulator. Since the macroparticle can be kept in a stable orbit by a Braunbeck levitation configuration, the guide field can be static. The macroparticle can then be slowly accelerated along its circular track by a travelling magnetic wave, the field strength of which can be much weaker than the strength of the guide field so that the travelling wave can be generated by ordinary magnetic field coils. In a typical example, the accelerator would have a circumference of about 10 km and, to reach a velocity of about 200 km·s−1 as needed for impact fusion, the projectile would have to make about ten runs with an acceleration length of ∼ 100 km. For a gram-size projectile the kinetic energy would be large enough to ignite a thermonuclear microexplosion.
Bioactive Synthetic-Bioinformatic Natural Product Cyclic Peptides Inspired by Nonribosomal Peptide Synthetase Gene Clusters from the Human Microbiome (2019)

Bioinformatic analysis of sequenced bacterial genomes has uncovered an increasing number of natural product biosynthetic gene clusters (BGCs) to which no known bacterial metabolite can be ascribed. One emerging method we have investigated for studying these BGCs is the synthetic-Bioinformatic Natural Product (syn-BNP) approach. The syn-BNP approach replaces transcription, translation, and <i>in vivo</i> enzymatic biosynthesis of natural products with bioinformatic algorithms to predict the output of a BGC and <i>in vitro</i> chemical synthesis to produce the predicted structure. Here we report on expanding the syn-BNP approach to the design and synthesis of cyclic peptides inspired by nonribosomal peptide synthetase BGCs associated with the human microbiota. While no syn-BNPs we tested inhibited the growth of bacteria or yeast, five were found to be active in the human cell-based MTT metabolic activity assay. Interestingly, active peptides were mostly inspired by BGCs found in the genomes of opportunistic pathogens that are often more commonly associated with environments outside the human microbiome. The cyclic syn-BNP studies presented here provide further evidence of its potential for identifying bioactive small molecules directly from the instructions encoded in the primary sequences of natural product BGCs.
Biological therapies for posttraumatic stress disorder: an overview. (1997)

Both core and secondary symptoms of posttraumatic stress disorder (PTSD) respond to medication, a valuable part of overall PTSD treatment. Treatment options include antidepressants, anxiolytics, anticonvulsants, and mood stabilizers. A growing data base of results from double-blind, placebo-controlled clinical trials supports the use of antidepressants, especially tricyclics, monoamine oxidase inhibitors (MAOIs), and serotonin selective reuptake inhibitors (SSRIs). Although heightened anxiety is characteristic of PTSD, benzodiazepines have not yet proved useful in controlled trials and may be associated with a rebound effect on discontinuation. The small, open studies of anticonvulsant drugs indicate moderate to good improvement with these agents. Tricyclic, SSRI, and MAOI antidepressants have demonstrated efficacy in larger, longer-term controlled trials. Drug/psychotherapy combinations may enhance the usefulness of psychotherapeutics in the management of PTSD. Studies with tricyclics and fluoxetine indicate that magnitude and type of trauma may determine the degree of response.
Calcium-Channel Blocking and Nanoparticles-Based Drug Delivery for Treatment of Drug-Resistant Human Cancers (2014)

All of these analytical assays confirmed the ability to reduce the chemoresistance of the cancer cells based on the proposed procedure.