gebhart/patrepeval huggingface dataset:
Naloxone Enhances Cerebral Reactive Hyperemia in the Rat (1985)

Cerebral blood flow (CBF) in the rat was monitored by a venous outflow technique with an extracorporeal circulation, which allows for the continuous recording of CBF over several hours. Morphine and the opiate antagonist, naloxone, were tested for their effects on the reactive hyperemia that follows a brief anoxic challenge. Morphine (5.0 mg/kg) significantly reduced the peak increase in flow during the hyperemia and, at both of the doses used (1.0 and 5.0 mg/kg), caused a small, nonsignificant increase in the duration of the reactive hyperemia. Naloxone (0.1 and 1.0 mg/kg) enhanced basal CBF rates and significantly prolonged the duration of the reactive hyperemia. These effects of naloxone may account for its beneficial effects in the treatment of cerebral ischemia.
Complex Compound Chemical Heat Pumps (1987)

Complex-compound solid-vapor fluid pairs can be used in heat of reaction heat pumps for temperature amplifier (TA) as well as heat amplifier (HA) cycle configurations. This report describes the conceptual hardware design for complex compound industrial heat pumps. The main emphasis was directed towards a conceptual temperature amplifier bench scale prototype design, which allows for the conversion to heat amplifier operation by the mere exchange of adsorbent working fluid component without hardware modification. The heat pump design is based on a heat pump cycle. The fluid development focuses on hydrated and ammoniated complex compounds in the temperature range 80°C to 160°C.
Effects of Dietary Intake of Soy Protein and Isoflavones on Cardiovascular Disease Risk Factors in High Risk, Middle-Aged Men in Scotland (2004)

Dietary intakes of soy protein (at least 20 g) and isoflavones (at least 80 mg) for 5 weeks would be effective in reducing CHD risk among high-risk, middle-aged men.
Glutathione as a depigmenting agent: an overview (2005)

Glutathione is an ubiquitous compound found in our bodies. Aside from its many ascribed biologic functions, it has also been implicated in skin lightening. We review in vitro and in vivo studies that show evidence of its involvement in the melanogenic pathway and shed light on the its anti-melanogenic effect. Proposed mechanisms of action include: (a) direct inactivation of the enzyme tyrosinase by binding with the copper-containing active site of the enzyme; (b) mediating the switch mechanism from eumelanin to phaeomelanin production; (c) quenching of free radicals and peroxides that contribute to tyrosinase activation and melanin formation; and d) modulation of depigmenting abilities of melanocytotoxic agents. These concepts supported by the various experimental evidence presented form basis for future research in the use of glutathione in the treatment of pigmentary disorders.
An Efficient Synthesis of Pyrrolo[2,3,4-<i>kl</i>]acridin-1-one Derivatives Catalyzed by <scp>l</scp>-Proline (2012)

An efficient domino approach for the synthesis of novel pyrrolo[2,3,4-kl]acridin-1-one derivatives has been established. This reaction represents the first facile conversion of an isatin to a pyrrolo[2,3,4-kl]acridin-1-one via a C-N bond cleavage reaction without the need for a multistep reaction process.
The Question of Family: Lesbians and Gay Men Reflecting A Redefined Society (1992)

The cutting edge issue in the gay community is now the fight for domestic partnership rights. The absence of domestic partnership rights have resulted in the unequal treatment of an entire class of citizens, with gays and lesbians routinely denied jobs, housing, economic benefits such as health care, insurance, public accommodations, and may even result in these individuals being fired or facing eviction solely because of their sexual orientation. The author argues that to rectify these injustices, we must redefine the definition of family to be more in line with that used in New York's Braschi v. Stahl Assocs. Co., decision. In Braschi, the court stated that the term family included an unmarried lifetime gay partner and not just persons related by blood or law. The author also advocates for an advancement of legislative initiatives, like domestic partnership laws to remedy the injustices faced by gays and lesbians.
When Fear Is Near: Threat Imminence Elicits Prefrontal-Periaqueductal Gray Shifts in Humans (2007)

Humans, like other animals, alter their behavior depending on whether a threat is close or distant. We investigated spatial imminence of threat by developing an active avoidance paradigm in which volunteers were pursued through a maze by a virtual predator endowed with an ability to chase, capture, and inflict pain. Using functional magnetic resonance imaging, we found that as the virtual predator grew closer, brain activity shifted from the ventromedial prefrontal cortex to the periaqueductal gray. This shift showed maximal expression when a high degree of pain was anticipated. Moreover, imminence-driven periaqueductal gray activity correlated with increased subjective degree of dread and decreased confidence of escape. Our findings cast light on the neural dynamics of threat anticipation and have implications for the neurobiology of human anxiety-related disorders.
Phase II study of weekly edatrexate as first-line chemotherapy for metastatic breast cancer: a National Cancer Institute of Canada Clinical Trials Group study. (1993)

Edatrexate is an active agent against metastatic breast cancer, with acceptable toxicity. A lower than planned delivered dose-intensity was mainly due to mucositis.
Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking (2008)

The protein tyrosine phosphatase Shp2 is a positive regulator of growth factor signaling. Gain-of-function mutations in several types of leukemia define Shp2 as a bona fide oncogene. We performed a high-throughput in silico screen for small-molecular-weight compounds that bind the catalytic site of Shp2. We have identified the phenylhydrazonopyrazolone sulfonate PHPS1 as a potent and cell-permeable inhibitor, which is specific for Shp2 over the closely related tyrosine phosphatases Shp1 and PTP1B. PHPS1 inhibits Shp2-dependent cellular events such as hepatocyte growth factor/scatter factor (HGF/SF)-induced epithelial cell scattering and branching morphogenesis. PHPS1 also blocks Shp2-dependent downstream signaling, namely HGF/SF-induced sustained phosphorylation of the Erk1/2 MAP kinases and dephosphorylation of paxillin. Furthermore, PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines. The PHPS compound class is therefore suitable for further development of therapeutics for the treatment of Shp2-dependent diseases.
Composite sandwich structures with rapid prototyped cores (2011)

Purpose The purpose of this paper is to investigate the feasibility of using rapid prototyping (RP) technologies (stereolithography (SLA), fused deposition modeling (FDM), and three‐dimensional printing (3DP)) for fabrication of the core of a composite sandwich structure. Design/methodology/approach Control cores of a flat geometry were fabricated from epoxy using SLA and from acrylonitrile butadiene styrene (ABS) plastic using FDM. Corrugated geometry cores were fabricated using SLA, FDM, and 3DP. Carbon‐epoxy composite sandwich structures were fabricated from all cores using a wet‐hand layup process with vacuum cure. The performance of each core was measured using a bend test to determine bending stiffness and failure load. Findings Based upon bending stiffness and failure load, composite sandwich structures utilizing epoxy cores fabricated via SLA outperformed composite sandwich structures utilizing plaster powder and ABS plastic cores. Composite sandwich structures with corrugated ABS plastic cores outperformed those with flat ABS plastic cores by a margin well beyond that predicted by theory in both bending stiffness and failure load. Research limitations/implications The marked improvement in stiffness and failure load of the composite sandwich structures with corrugated ABS plastic cores over those with flat ABS cores is not explained by the theoretical improvement due to an increased area moment of inertia and increased surface area. Additional research in the failure mechanism is warranted. Practical implications The ability to easily create complex core geometries will allow for the ability to place enhanced structural features in the regions of high stress. Originality/value This paper demonstrates that cores fabricated via RP technology and containing enhanced structural features are suitable for carbon‐epoxy composite sandwich structures.
Differential effects of repeated ovarian stimulation on cytoplasmic and spindle organization in metaphase II mouse oocytes matured in vivo and in vitro (2001)

The effects of four rounds of ovarian stimulation spaced 1-6 weeks apart on the normality of metaphase II (MII) spindle formation, chromosomal alignment and cytoplasmic organization were examined in intact ovulated mouse oocytes and at MII for oocytes obtained at the germinal vesicle stage from the same ovaries and matured in vitro. The terminal deoxynucleotidyl transferase-mediated dUDP nick-end labelling assay was used to identify DNA strand breaks in chromosomes, and histological studies of ovaries between and at each round of ovarian stimulation were performed. The results demonstrate a progressive and significant increase in the frequency of spindle defects with each round of ovarian stimulation, including those spaced weeks apart. Oocytes with spindle defects were also characterized by the occurrence of detached chromosomes and cytoplasmic asters. In contrast, in-vitro matured oocytes derived from the same ovaries were normal. No evidence of DNA strand breaks with repeated rounds of ovarian stimulation was detected in ovulated or in-vitro matured oocytes. The development and persistence of nodules of hypertrophied granulosa in regions where follicular growth occurs suggest that a progressively increasing proportion of oocytes in the ovulatory pathway may experience an intrafollicular milieu that has negative consequences for competence. The results are discussed with respect to ovarian and oocyte biological ageing and possible adverse implications for human oocyte competence with repeated hyperstimulation.
Three-core ARROW-type diode laser: novel high-power, single-mode device, and effective master oscillator for flared antiguided MOPA's (1995)

A novel type of strong-index-guided laser structure for achieving coherent, high-power (/spl sim/1 W) reliable operation is proposed, analyzed, and demonstrated for the first time. The three-core antiresonant-reflective-optical waveguide (ARROW) laser combines the relatively large fabrication tolerances of single-core ARROW-type devices with the excellent intermodal-discrimination properties of small-element-number (<10) resonant antiguided arrays (i.e., resonant optical-waveguide (ROW) devices.) Thus, the three-core ARROW device should prove a more practical device to fabricate than large element (>10) ROW arrays, which are known to have tight fabrication tolerances. For single-spatial-mode selectivity the device relies both on ARROW-type (lateral) reflectors and interelement loss. The effect of interelement loss on the resonant in-phase mode and the unwanted nonresonant modes is calculated, and the results are used to design optimal structures. For structures of index step, /spl Delta/n, of 0.1; element/interelement width ratio of 5; 500 cm/sup -1/ interelement-loss coefficient; and 7.5-/spl mu/m-wide individual elements, intermodal discrimination /spl ges/5 cm/sup -1/ is obtained over a relatively large range in /spl Delta/n: /spl sim/0.01. Above-threshold analysis shows that, due to strong index guiding, the structures are virtually immune to gain spatial hole burning. The central-lobe energy content is 65-70%, and the emitting aperture is 25 /spl mu/m, which should provide 1 W CW reliable single-mode power from devices with oxide-free facets. Preliminary experimental results are obtained from Al-free 0.98-/spl mu/m emitting structures: diffraction-limited beam operation up to 30/spl times/ threshold and 0.55 W peak pulsed output power. Finally it is shown that three-core ARROW devices used as integrated master oscillators (MO's) for flared antiguided master-oscillator power amplifiers (MOPA's), provide uniform MOPA near-field intensity profiles, thus opening the way to achieving 3-5 W CW diffraction-limited power from stable, flared MOPA's.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A WEIGHTED GENERALIZED LS-SVM (2003)

Neural networks play an important role in system modelling. This is especially true if model building is mainly based on observed data. Among neural models the Support Vector Machine (SVM) solutions are attracting increasing attention, mostly because they automatically answer certain crucial questions involved by neural network construction. They derive an ‘optimal ’ network structure and answer the most important question related to the ‘quality ’ of the resulted network. The main drawback of standard Support Vector Machines (SVM) is its high computational complexity, therefore recently a new technique, the Least Squares SVM (LS–SVM) has been introduced. This is algorithmically more effective, because the solution can be obtained by solving a linear equation set instead of a computation-intensive quadratic programming problem. Although the gain in efficiency is rather significant, for really large problems the computational burden of LS-SVM is still too high. Moreover, an attractive feature of SVM, its sparseness is lost. This paper proposes a special new generalized formulation and solution technique for the standard LS-SVM. By solving the modified LS–SVM equation set in least squares (LS) sense (LS2 –SVM), a pruned solution is achieved, while the computational burden is further reduced (Generalized LS–SVM). In this generalized LS–SVM framework a further modification weighting is also proposed, to reduce the sensitivity of the network construction to outliers while maintaining sparseness.
STUDIES ON MANGANESE‐ACCUMULATING <i>ALYXIA</i> SPECIES FROM NEW CALEDONIA (1981)

Summary Thirty‐one species of Alyxia from New Caledonia were analysed for their manganese content. Most of the species showed excessive uptake of manganese with a maximum of 1.15% Mn in dried leaves of A. rubricaulis. The manganese content alone was sufficient to distinguish a number of species from each other. Composite samples were in addition analysed for calcium, magnesium, potassium and sodium. Correlation analysis and calculation of the slopes of regression lines showed that manganese uptake was mainly at the expense of calcium, rather than magnesium. Similarly magnesium was preferred to potassium and potassium to sodium. It is possible that manganese may have some physiological role in Alyxia , compensating to some extent for reduced uptake of the nutrients calcium and potassium.
Hyaluronan-Tethered Opioid Depots: Synthetic Strategies and Release Kinetics<i>In Vitro</i>and<i>In Vivo</i> (2008)

We proposed the use of opioid drug bound covalently to hyaluronan (HA) via ester linkages as a method to prolong drug delivery and to possibly increase the quality of perioperative pain management. The in vitro release profile of morphine conjugated to HA (1.3 million MW) was studied. The influence of parameters such as conjugation site and steric protection of the labile ester bonds was investigated in phosphate buffered saline (PBS) medium. HA--codeine and HA--naloxone conjugates were used as structural controls. Codeine and morphine conjugated via the allylic hydroxyl group had a release half-life of 14.0 days in PBS. Naloxone conjugated via the phenolic hydroxyl group showed a half-life of 0.3 days, and all drugs admixed in HA showed half-lives of 0.1 days. Methyl, ethyl, or n-propyl introduced in vicinal position to the ester bond prolonged release of naloxone with half-lives of 0.5, 4.0, and 4.0 days in PBS, respectively. Incorporation of a methyl group prolonged codeine release with a half-life of 55.0 days in PBS. Drugs were released chemically unaltered from the conjugates as confirmed by LC-MS/MS. Further, morphine was conjugated to divinylsulfone cross-linked HA (Hylan B) particles and the release profiles in rat plasma were studied in vitro and in vivo. Release in rat plasma was faster than in PBS with a half-life of 2.5 days, but the release was similar (ca. 12 days) when a cocktail of protease inhibitors was added to the plasma. Sustained release of morphine was observed in a rat surgical model over 30 h. Morphine was released chemically unaltered from the conjugate and morphine intermediates were not detected in significant amounts as confirmed by LC-MS/MS. These results suggest that the morphine release profile from the HA conjugates depends on the alkyl groups vicinal to the ester and the nature of the leaving group. In rat plasma, hydrolysis seems to be controlled by esterase activity.
Realization of a short integrated optic passive polarization converter (1995)

For the first time, passive polarization converters with lengths of less than 1 mm and high polarization conversions are realized on InGaAsP-InP. Angled facets in a periodic coupler are used to obtain efficient conversion. Polarization conversions of more than 70%, respectively more than 90%, are measured for two different realizations of the angled facets. The most promising technology used in the realization results in a propagation loss of less than 1 dB/mm for both polarizations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Efficient mapping algorithm of multilayer neural network on torus architecture (2003)

This paper presents a new efficient parallel implementation of neural networks on mesh-connected SIMD machines. A new algorithm to implement the recall and training phases of the multilayer perceptron network with back-error propagation is devised. The developed algorithm is much faster than other known algorithms of its class and comparable in speed to more complex architecture such as hypercube, without the added cost; it requires O(1) multiplications and O(log N) additions, whereas most others require O(N) multiplications and O(N) additions. The proposed algorithm maximizes parallelism by unfolding the ANN computation to its smallest computational primitives and processes these primitives in parallel.
Determinants of Lumbar Disc Degeneration (1995)

The present study findings suggest that disc degeneration may be explained primarily by genetic influences and by unidentified factors, which may include complex, unpredictable interactions. The particular environmental factors studied, which have been among those most widely suspected of accelerating disc degeneration, had very modest effects.
Standard methods to test the side‐effects of pesticides on natural enemies of insects and mites developed by the IOBC/WPRS Working Group ‘Pesticides and Beneficial Organisms’ (1985)

A short description is given of 19 laboratory, 12 semi‐field and 5 field methods to test the side‐effects of pesticides on beneficial organisms. The methods were developed according to standard guidelines by members of the Working Group ‘Pesticides and Beneficial Organisms’ of the International Organization for Biological Control (IOBC), West Palaearctic Regional Section (WPRS); 28 members in nine countries participated and the beneficial organisms (natural enemies of insects and mites) included: 6 Hymenoptera, 4 Coleoptera, 2 Diptera, 1 Neuroptera, 1 Heteroptera, 3 Acari, 1 Aranea, 1 entomopathogenic fungus (Hyphomycetes). There is agreement that a combination of laboratory, semi‐field and field tests is needed to show the side‐effects of pesticides on beneficial organisms and that the beneficials chosen for the test should be relevant to the crop on which the pesticide is to be used.
Phase-controlling phononic crystals: Realization of acoustic Boolean logic gates (2011)

A phononic crystal (PC) consisting of a square array of cylindrical polyvinylchloride inclusions in air is used to construct a variety of acoustic logic gates. In a certain range of operating frequencies, the PC band structure shows square-like equi-frequency contours centered off the gamma point. This attribute allows for the realization of non-collinear wave and group velocity vectors in the PC wave vector space. This feature can be utilized to control with great precision, the relative phase between propagating acoustic waves in the PC. By altering the incidence angle of the impinging acoustic beams or varying the PC thickness, interferences occur between acoustic wave pairs. It is recognized that information can be encoded with this mechanism (e.g., wave amplitudes/interference patterns) and accordingly to construct a series of logic gates emulating Boolean functions. The NAND, XOR, and NOT gates are demonstrated with finite-difference time-domain simulations of acoustic waves impinging upon the PC.
DTIC, CCNU, bleomycin and vincristine (BOLD) in metastatic melanoma (1980)

Treatment of 91 consecutive patients having metastatic, Stage IV melanoma who had not received any previous chemotherapy was begun between January 1977 and April 1978. The therapy included bleomycin (B) at 7.5 units subcutaneously in the first course and 15 units in subsequent courses on days 1 and 4; vincristine or Oncovin (O) at 1 mg/m2 intravenously on days 1 and 5; CCNU or lomustine (L) at 80 mg/m2 p.o. on day 1 and DTIC (D) 200 mg/m2 intravenously on days 1 through 5. Evaluable patients (72) were those who had measurable tumours in the viscera and on the skin. Seven patients (9%) responded with complete tumor regression (CR), 22 (31%) with partial regression (PR) (50% or more tumor regression), 12 (17%) with stabilization of disease, and 31 (43%) with progression of the disease. Patients who responded with CR, PR, and stable disease (41 patients) had a median survival of 67 weeks, while those who did not respond (31 patients) had a median survival of 20 weeks (P < .0001). Overall median survival was 31 weeks. The bleomycin-Oncovin-lomustine-DTIC (BOLD) regimen is an effective alternative treatment for metastatic melanoma; there is good tumor response and prolongation of survival in the responding patients. Its overall toxicity is mild to moderate.
Preliminary Experience of ARMS: A Web Service Based Automatic Resource Management System (2002)

multimedia services, resource management, web services, authentication, access control, Kerberos, grid computing, remote visualization To build a rich-media service grid for automatically managing the life-cycle activities of services, it is essential to have an automatic resource management system to provide a cost-bounded capacity guarantee illusion to services over distributed heterogeneous resources. In this paper, we describe our preliminary
GNSS Acquisition in the Presence of Continuous Wave Interference (2010)

The extreme weakness of a global navigation satellite system (GNSS) signal makes it vulnerable to a wide variety of interfering signals, falling within the GNSS frequency bands. One of the main classes of these disturbing signals is represented by continuous wave interference (CWI), which include all signals that can be effectively represented as pure sinusoids. This paper deals with the performance of GNSS signal acquisition in the presence of CWI. An original model describing the impact of CWI on signal acquisition is proposed and the expressions of both false alarm and detection probabilities are mathematically formulated and validated by Monte Carlo simulations. The paper also investigates the role of the interference amplitude and frequency along with the impact of different system parameters on the detection and false alarm probabilities.