gebhart/patrepeval huggingface dataset:
Greening Residential Wi-Fi Networks under Centralized Control (2014)

Residential broadband gateways (comprising modem, router, and Wi-Fi access point), though individually consuming only 5-10 Watts of power, are significant contributors to overall network energy consumption due to large deployment numbers. Moreover, home gateways are typically always on, so as to provide continuous online presence to household devices for VoIP, smart metering, security surveillance, medical monitoring, etc. A natural solution for reducing the energy consumption of home gateways is to leverage the overlap of Wi-Fi networks common in urban environments and aggregate user traffic on to fewer gateways, thus putting the remaining to sleep. In this paper we propose, evaluate, and prototype an architecture that overcomes significant challenges in making this solution feasible at large-scale. We advocate a centralized approach, whereby a single authority co-ordinates the home gateways to maximize energy savings in a fair manner. Our solution can be implemented across heterogeneous ISPs, avoids client-side modifications (thus encompassing arbitrary user devices and operating systems), and permits explicit control of session migrations. We apply our solution to Wi-Fi traces collected in a building with 30 access points and 25,000 client connections, and evaluate via simulation the tradeoffs between energy savings, session disruptions, and fairness. We then prototype our system on commodity Wi-Fi access points, test it in a two-storey building emulating 6 residences, and demonstrate radio energy reduction of over 60 percent with little impact on user experience.
Possible new mechanism of cortisol action in female reproductive organs: physiological implications of the free hormone hypothesis (2002)

The so-called free hormone hypothesis predicts that the biological activity of a given steroid correlates with the free protein-unbound concentration rather than with the total concentration (i.e. free plus protein-bound). Cortisol is a glucocorticoid with many diverse functions and the free hormone hypothesis seems to apply well to the observed effects of cortisol. The ovaries express glucocorticoid receptors and are affected by cortisol, but lack the necessary enzymes for cortisol synthesis. Ovarian follicles modulate the biological activity of cortisol by (1) follicular production of especially progesterone and 17 alpha-hydroxy-progesterone which, within the follicle, reach levels that displace cortisol from its binding proteins, in particular, cortisol-binding protein, making it available for biological action and (2) a developmental regulated expression of two types of 11 beta-hydroxysteroid dehydrogenase (i.e. 11 beta-HSD type 1 and type 2), which oppose the action of one another, the 11 beta-HSD type 2 predominantly inactivating cortisol to cortisone, while 11 beta-HSD type 1 reverses this reaction. As a result, a high concentration of cortisol available for biological action is present in the preovulatory follicle just prior to ovulation and it has been suggested that cortisol may function to reduce the inflammatory-like reactions occurring in connection with ovulation. This paper suggests (1) that the function of the oviduct is also affected by the high levels of free cortisol released in preovulatory follicular fluid at ovulation and (2) that formation and function of the corpus luteum benefits from a high local concentration of free cortisol, whereas the surrounding developing follicles may experience negative effects. If this hypothesis proves correct it may describe a new physiological mechanism by which cortisol interacts with the female reproductive organs, showing that the biologically active concentration of a steroid locally can be regulated to serve specific functions.
Use of fluorquinolones is associated with a reduced risk of coronary heart disease in diabetes mellitus type 2 patients (2002)

Our results suggest that treatment with fluorquinolones in doses commonly prescribed in routine clinical practice is associated with a reduction in the risk of coronary heart diseases among diabetes mellitus type 2 patients.
Guanidinophosphazenes:  Design, Synthesis, and Basicity in THF and in the Gas Phase (2005)

A principle for creating a new generation of nonionic superbases is presented. It is based on attachment of tetraalkylguanidino, 1,3-dimethylimidazolidine-2-imino, or bis(tetraalkylguanidino)carbimino groups to the phosphorus atom of the iminophosphorane group using tetramethylguanidine or easily available 1,3-dimethylimidazolidine-2-imine. Seven new nonionic superbasic phosphazene bases, tetramethylguanidino-substituted at the P atom, have been synthesized. Their base strengths are established in tetrahydrofuran (THF) solution by means of spectrophotometric titration and compared with those of eight reference superbases designed specially for this study, P2- and P4-iminophosphoranes. The gas-phase basicities of several guanidino- and N',N',N'',N''-tetramethylguanidino (tmg)-substituted phosphazenes and their cyclic analogues are calculated, and the crystal structures of (tmg)3P=N-t-Bu and (tmg)3P=N-t-Bu x HBF4 are determined. The enormous basicity-increasing effect of this principle is experimentally verified for the tetramethylguanidino groups in the THF medium: the basicity increase when moving from (dma)3P=N-t-Bu (pKalpha = 18.9) to (tmg)3P=N-t-Bu (pKalpha = 29.1) is 10 orders of magnitude. A significantly larger basicity increase (up to 20 powers of 10) is expected (based on the high-level density functional theory calculations) to accompany the similar gas-phase transfer between the (dma)3P=NH and (tmg)3P=NH bases. Far stronger basicities still are expected when, in the latter two compounds, all three dimethylamino (or tetramethylguanidino) fragments are replaced by methylated triguanide fragments, (tmg)2C=N-. The gas-phase basicity (around 300-310 kcal/mol) of the resulting base, [(tmg)2C=N-]3P=NH, having only one phosphorus atom, is predicted to exceed the basicity of (dma)3P=NH by more than 40 powers of 10 and to surpass also the basicity of the widely used commercial [(dma)3P=N]3P=N-t-Bu (t-BuP4) superbase.
Biofilms in Ear, Nose, and Throat Infections: How Important are They? (2007)

As the role of biofilms in human infection becomes better defined, ENT surgeons should be prepared to deal with their unique and tenacious nature.
Enhancing Protein Stability with Genetically Encoded Noncanonical Amino Acids (2018)

The ability to add noncanonical amino acids to the genetic code may allow one to evolve proteins with new or enhanced properties using a larger set of building blocks. To this end, we have been able to select mutant proteins with enhanced thermal properties from a library of E. coli homoserine O-succinyltransferase ( metA) mutants containing randomly incorporated noncanonical amino acids. Here, we show that substitution of Phe 21 with ( p-benzoylphenyl)alanine (pBzF), increases the melting temperature of E. coli metA by 21 °C. This dramatic increase in thermal stability, arising from a single mutation, likely results from a covalent adduct between Cys 90 and the keto group of pBzF that stabilizes the dimeric form of the enzyme. These experiments show that an expanded genetic code can provide unique solutions to the evolution of proteins with enhanced properties.
Optical techniques for the determination of nitrate in environmental waters: Guidelines for instrument selection, operation, deployment, maintenance, quality assurance, and data reporting (2013)

The recent commercial availability of in situ optical sensors, together with new techniques for data collection and analysis, provides the opportunity to monitor a wide range of water-quality constituents on time scales in which environmental conditions actually change. Of particular interest is the application of ultraviolet (UV) photometers for in situ determination of nitrate concentrations in rivers and streams. The variety of UV nitrate sensors currently available differ in several important ways related to instrument design that affect the accuracy of their nitrate concentration measurements in different types of natural waters. This report provides information about selection and use of UV nitrate sensors by the U.S. Geological Survey to facilitate the collection of high-quality data across studies, sites, and instrument types. For those in need of technical background and information about sensor selection, this report addresses the operating principles, key features and sensor design, sensor characterization techniques and typical interferences, and approaches for sensor deployment. For those needing information about maintaining sensor performance in the field, key sections in this report address maintenance and calibration protocols, quality-assurance techniques, and data formats and reporting. Although the focus of this report is UV nitrate sensors, many of the principles can be applied to other in situ optical sensors for water-quality studies.
Cyclophanes. IV. Synthesis of new [34]paracyclophanes containing four imidazole rings. (1988)

New [34]paracyclophanes, 5, 14, 29, 38-tetrakis(4-halophenyl)tetraimidazolo[34]paracyclophanes (9), were synthesized by the convenient one-pot coupling reaction of 1, 4-bis(2-isocyano-2-tosylethyl)benzene (1b) with 1, 4-bis[(4-halophenyl)iminomethyl]benzenes (7). On the basis of the proton nuclear magnetic resonance and the ultraviolet spectra it was suggested that the products 9, as well as the open-chain reference compounds (11), maintain coplanarity of the three linked aromatic rings, i.e., imidazole, benzene, and imidazole.
Local administration of <i>N</i>‐acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats (2007)

The peptide neurotransmitter N-acetylaspartylglutamate (NAAG) selectively activates group II metabotropic glutamate receptors (mGluRs). Systemic administration of inhibitors of the enzymes that inactivate NAAG results in decreased pain responses in rat models of inflammatory and neuropathic pain. These effects are blocked by a group II mGluR antagonist. This research tested the hypothesis that some analgesic effects of NAAG peptidase inhibition are mediated by NAAG acting on sensory neurite mGluRs at the site of inflammation. Group II mGluR agonists, SLx-3095-1, NAAG and APDC, or NAAG peptidase inhibitors, ZJ-43 and 2-PMPA, injected into the rat footpad reduced pain responses in carrageenan or formalin models. The analgesic effects of SLx-3095-1, APDC, ZJ-43, 2-PMPA and NAAG were blocked by co-injection of LY341495, a selective group II mGluR antagonist. Injection of group II mGluR agonists, NAAG or the peptidase inhibitors into the contralateral rat footpad had no effect on pain perception in the injected paw. At 10-100 microm ZJ-43 and 2-PMPA demonstrated no consistent agonist activity at mGluR2 or mGluR3. Consistent with the conclusion that peripherally administered NAAG peptidase inhibitors increase the activation of mGluR3 by NAAG that is released from peripheral sensory neurites, we found that the tissue average concentration of NAAG in the unstimulated rat hind paw was about 6 microm. These data extend our understanding of the role of this peptide in sensory neurons and reveal the potential for treatment of inflammatory pain via local application of NAAG peptidase inhibitors at doses that may have little or no central nervous system effects.
Effects of Resonant Magnetic Fields on Chick Femoral Development <i>In Vitro</i> (1991)

To assess the possibility that specific ionic resonances can influence bone development, 8-day chick femoral rudiments were explanted to lens paper rafts in BGJb medium and exposed for 1/2 hr/day to combined 16 or 80 Hz, 2 × 10−5 T (Tesla) peak sinusoidal and various static magnetic fields tuned to calcium, magnesium, potassium (16 Hz), and combined Ca/Mg (80 Hz) ion cyclotron resonances (CR) for I days. Ca/Mg tuned cultures were also exposed to 24, 4, 1, and 1/2 hr/day regimes to test for dose-response. Tuning for Ca, Mg, or Ca/Mg increased rudiment length and mid-shaft diameter, diaphyseal collar length
Prenatal MR imaging of dural sinus malformation: a case report (2005)

Prenatal MR imaging is useful to establish the diagnosis, to assess complications such as hydrocephalus and tonsillar prolapse, and to help plan perinatal management, postnatal follow-up, and treatment decision-making.
Use of Synthetic Derivatives To Determine the Minimal Active Structure of Cytokine-Inducing Lipoteichoic Acid (2007)

Lipoteichoic acid (LTA) from gram-positive bacteria is the counterpart to lipopolysaccharide from gram-negative bacteria. LTA, which activates Toll-like receptor 2 (TLR2), induces a unique cytokine and chemokine pattern. The chemical synthesis of LTA proved its immunostimulatory properties. To determine the minimal active structure of LTA, we reduced synthetic LTA in a number of steps down to the synthetic anchor and employed these molecules to stimulate interleukin-8 (IL-8) release in human whole blood. Ten times more of the synthetic structures with four to six d-alanine-substituted polyglycerophosphate units (50 nM) than of the native LTA preparation was required to induce IL-8 release. A further reduction to three backbone units with two or no d-alanine residues resulted in cytokine induction only from 500 nM. The synthetic anchor was not able to induce IL-8 release even at 5 muM. When the LTA derivatives were used at 500 nM, they induced increasing levels of IL-8 and tumor necrosis factor alpha with increasing elongation of the backbone. Peritoneal macrophages were less responsive than human blood to the synthetic structures. Therefore, TLR2 dependency could be shown only with cells from TLR2-deficient mice for the two largest synthetic structures. This was confirmed by using TLR2-transfected HEK 293 cells. Taken together, these data indicate that although the synthetic anchor (which, unlike the native anchor, contains only myristic acid) cannot induce cytokine release, the addition of three backbone units, even without d-alanine substituents, confers this ability. Lengthening of the chain with d-alanine-substituted backbone units results in increased cytokine-inducing potency and a more sensitive response.
ao xiao zuo lv hua na zhu she ye xi jun nei du su de jian ce (2005)

目的建立奥硝唑氯化钠注射液的细菌内毒素检查法.方法参照 2000年版二部附录收载的细菌内毒素检查法要求进行实验.结果将样品作3倍稀释可有效消除对鲎实验的干扰.结论可用细菌内毒素法来控制奥硝唑氯化钠注射液的质量.
Handbook of tensile properties of textile and technical fibres (2009)

Introduction to fibre tensile properties and failure Tensile testing of textile fibres. Part 1 Tensile properties and failure of natural fibres: Tensile properties of cotton fibres Tensile properties of hemp and Agave americana fibres Tensile failure of wool Types, structure and mechanical properties of silk Structure and behaviour of collagen fibers. Part 2 Tensile properties and failure of synthetic fibres: Manufacturing, properties and tensile failure of nylon fibres The chemistry, manufacture and tensile behaviour of polyester fibres Tensile properties of polypropylene fibres Tensile fatigue of thermoplastic fibres Liquid crystalline organic fibres and their mechanical behaviour The manufacture, properties and applications of high strength, high modulus polyethylene fibers Tensile failure of polyacrylonitrile fibres Structure and properties of glass fibres Tensile failure of carbon fibres The mechanical behaviour of small diameter silicon carbide fibres The structure and tensile properties of continuous oxide fibers.
Template-Free Deposition of Polyaniline Nanostructures on Solid Substrates with Horizontal Orientation (2011)

By investigating the electrochemical nucleation and growth of polyaniline (PANI) on the insulating gap area of an interdigitated electrode, a template-free, in-situ approach is developed to obtain PANI nanowires and nanofibers with horizontal orientation on solid substrates. Experimental results show that the deposition process of PANI on the gap area is significantly influenced by polymerization conditions (such as polymerization current and time) and surface characteristics of the substrates (such as hydrophilicity/hydrophobicity and roughness). The concentration of solution-formed oligomers and the nucleation amount of the oligomers on the solid surface determine the morphology and orientation of the nanostructures. Controlling the deposition with high oligomer concentrations and limited nucleation amounts on the substrate is the key to the horizontal orientation. Gas sensing experiments confirm that the horizontal orientation of the nanostructures helps to improve the sensitivity and response time of sensor devices. Because of its simplicity, the approach proposed in this paper can be used in the fabrication of nanostructured conducting polymer chemiresistive gas sensor with high sensitivity but low cost.
Tire/road friction coefficient estimation applied to road safety (2010)

Recent statistics show that a large number of traffic accidents occur due to a loss of control on vehicle by the driver. This is mainly due to a loss of friction between tire and road. Many of these accidents could be avoided by introducing ADAS (Advanced Driver Assistance Systems) based on the detection of loss of tire/road friction. Friction (more specifically the maximum coefficient of friction) which is a parameter of tire/road interaction, mainly depends on the state of the road (dry, wet, snow, ice) and is closely related to the efforts at the tire level. In this paper, we propose, a new method for the estimation of the maximum tire/road friction coefficient, to automatically detect possible state of loss of friction which result in an abrupt change on the road state. This method is based on an iterative quadratic minimization of the error between the developed lateral force and the model of tire/road interaction. Results validate the application of the method.
Zero-shot Recognition via Semantic Embeddings and Knowledge Graphs (2018)

We consider the problem of zero-shot recognition: learning a visual classifier for a category with zero training examples, just using the word embedding of the category and its relationship to other categories, which visual data are provided. The key to dealing with the unfamiliar or novel category is to transfer knowledge obtained from familiar classes to describe the unfamiliar class. In this paper, we build upon the recently introduced Graph Convolutional Network (GCN) and propose an approach that uses both semantic embeddings and the categorical relationships to predict the classifiers. Given a learned knowledge graph (KG), our approach takes as input semantic embeddings for each node (representing visual category). After a series of graph convolutions, we predict the visual classifier for each category. During training, the visual classifiers for a few categories are given to learn the GCN parameters. At test time, these filters are used to predict the visual classifiers of unseen categories. We show that our approach is robust to noise in the KG. More importantly, our approach provides significant improvement in performance compared to the current state-of-the-art results (from 2 ~ 3% on some metrics to whopping 20% on a few).
Extremal points: definition and application to 3D image registration (1994)

This paper presents the extraction of feature points, geometrically invariant, which can be used as reliable landmarks for registration and recognition. Mainly we show that it is possible to extract automatically feature lines and points from 3D images, which are robust and invariant with respect to rigid transforms, and enough precise to perform the automatic registration. This extends the possible applications of "the Marching Lines" algorithm, previously described for extremal lines extraction. We introduce here a new kind of feature points: the Extremal Points, belonging to the extremal lines, which allow us to find a point to point correspondences between 3D images of the same subject. We present also experimental results of automatic registration with real data, which demonstrate the remarkable stability of those points.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pingu: A New Miniature Wearable Device for Ubiquitous Computing Environments (2012)

Around Device Interaction (ADI) is recently introduced in the field of Human Computer Interaction (HCI)to provide touch less, more intuitive way of interaction using space beyond the physical boundary of the computing devices. In this paper, we introduce a new ADI input device called Pingu in the form factor of a fingering that allows users to interact with any nearby computing device with wireless connectivity in a ubiquitous environment. Fingering form factor is chosen for our prototype design, as it is socially acceptable and is commonly worn in everyday social contexts, and based on the previous research, the information entropy of interaction by fingers is greater than the entropy for any other parts of the human body. The current Pingu prototype is consisted of an extensive set of sensors, visual and vibrot actile feedback mechanisms with wireless connectivity that make it a unique input device for human-computer or human-human interaction in the form of gestures, tactile and touch. Its usage can range from advanced, tiny and novel gestural interaction with a variety of devices to mobile and networked sensing, and social computing. We present a few potential applications of Pingu such as social interaction, context recognition, in-car interaction, and physical activity analysis.
Derived protein sequence, oligosaccharides, and membrane insertion of the 120-kDa lysosomal membrane glycoprotein (lgp120): identification of a highly conserved family of lysosomal membrane glycoproteins. (1988)

The 120-kDa lysosomal membrane glycoprotein (lgp120) is an acidic, heavily glycosylated membrane protein enriched in the lysosomal membrane. To determine the basis for its selective transport to and stability in lysosomes, we have investigated the structure of lgp120. By using an oligonucleotide probe corresponding to the amino terminus of rat lgp120, we isolated and characterized cDNA clones containing the entire coding region. The deduced amino acid sequence demonstrates that lgp120 contains a putative signal peptide, 18 sites for N-linked glycosylation, a single membrane-spanning segment, and a short (11 amino acid) cytosolic tail. The sequence suggests a distinct domain organization, with two luminal glycosylated regions separated by a nonglycosylated proline-rich region. Proteolysis in detergent showed that the protein was not intrinsically resistant to exogenous or endogenous proteases. The N-linked oligosaccharides on lgp120, tetraantennary structures with two lactosamine repeats on one of the branches, were not different from those of glycoproteins on the plasma membrane. lgp120 was similar in its domain organization and portions of its amino acid sequence to the avian 100-kDa lysosomal membrane protein LEP100 [Fambrough, D. M., Takeyasu, K., Lippincott-Schwartz, J., Siegel, N. R. & Somerville, D. (1988) J. Cell Biol. 106, 61-67], and to a distinct 110-kDa lysosomal membrane protein (lgp110) that colocalizes with lgp120. The similarities between lysosomal membrane glycoproteins from diverse species, coupled with the fact that at least two distinct lysosomal membrane glycoproteins are expressed in a single species, indicate the existence of a conserved family of glycoproteins enriched in the lysosomal membrane.