gebhart/patrepeval huggingface dataset:
Lattice, elastic, polarization, and electrostrictive properties of BaTiO3 from first-principles (2010)

Predicting the domain structures and properties in both bulk single crystal and thin film ferroelectrics using the phase-field approach requires the knowledge of fundamental mechanical, electrical, and electromechanical coupling properties of a single-domain state. In this work, the elastic properties and structural parameters of cubic single crystals as well as tetragonal, orthorhombic, and rhombohedral BaTiO3 single domain states are obtained using first-principles calculations under the local density approximation. The calculated lattice constants, bulk modulus, and elastic constants are in good agreement with experiments for both the cubic paraelectric phase and the low-temperature ferroelectric phases. Spontaneous polarizations for all three ferroelectric phases and the electrostrictive coefficients of cubic BaTiO3 are also computed using the Berry’s phase approach, and the results agree well with existing experimentally measured values.
Effect of Acid-Catalyzed Formation Rates of Benzimidazole-Linked Polymers on Porosity and Selective CO<sub>2</sub> Capture from Gas Mixtures (2015)

Benzimidazole-linked polymers (BILPs) are emerging candidates for gas storage and separation applications; however, their current synthetic methods offer limited control over textural properties which are vital for their multifaceted use. In this study, we investigate the impact of acid-catalyzed formation rates of the imidazole units on the porosity levels of BILPs and subsequent effects on CO2 and CH4 binding affinities and selective uptake of CO2 over CH4 and N2. Treatment of 3,3'-Diaminobenzidine tetrahydrochloride hydrate with 1,2,4,5-tetrakis(4-formylphenyl)benzene and 1,3,5-(4-formylphenyl)-benzene in anhydrous DMF afforded porous BILP-15 (448 m(2) g(-1)) and BILP-16 (435 m(2) g(-1)), respectively. Alternatively, the same polymers were prepared from the neutral 3,3'-Diaminobenzidine and catalytic amounts of aqueous HCl. The resulting polymers denoted BILP-15(AC) and BILP-16(AC) exhibited optimal surface areas; 862 m(2) g(-1) and 643 m(2) g(-1), respectively, only when 2 equiv of HCl (0.22 M) was used. In contrast, the CO2 binding affinity (Qst) dropped from 33.0 to 28.9 kJ mol(-1) for BILP-15 and from 32.0 to 31.6 kJ mol(-1) for BILP-16. According to initial slope calculations at 273 K/298 K, a notable change in CO2/N2 selectivity was observed for BILP-15(AC) (61/50) compared to BILP-15 (83/63). Similarly, ideal adsorbed solution theory (IAST) calculations also show the higher specific surface area of BILP-15(AC) and BILP-16(AC) compromises their CO2/N2 selectivity.
Chronic Thromboembolic Pulmonary Hypertension (2011)

Over the past 4 decades, chronic thromboembolic pulmonary hypertension has evolved from an autopsy curiosity to a potentially correctable form of pulmonary hypertension. Advances in surgical techniques along with the introduction of pulmonary hypertension disease-modifying therapies provide a therapeutic option for the majority of patients afflicted with the disease. Approximately 5,000 thromboendarterectomy procedures have now been performed worldwide with mortality rates reported by established programs experienced in the management of this disease process falling to a range of 4 to 7%. A mortality rate of 1.3% has been reported in patients at low risk based on their preoperative hemodynamic profile. After a successful pulmonary thromboendarterectomy, substantial improvement and often normalization can be achieved in right ventricular function, gas exchange, exercise capacity, and quality of life. For patients not candidates for thromboendarterectomy, or for those with persistent post-thromboendarterectomy pulmonary hypertension, disease-modifying medical therapies have been demonstrated to stabilize and improve pulmonary hemodynamics, albeit not to the same extent as primary thromboendarterectomy. The current review focuses on the diagnostic approach to chronic thromboembolic pulmonary hypertension and the available surgical and medical therapeutic options. Additional research is necessary to more accurately predict postoperative hemodynamic outcome and to define the optimal therapeutic approach, especially in patients with involvement of the distal vasculature.
Accounting for Parameter Uncertainty in Simulation Input Modeling (2003)

We formulate and evaluate a Bayesian approach to probabilistic input modeling for simulation experiments that accounts for the parameter and stochastic uncertainties inherent in most simulations and that yields valid predictive inferences about outputs of interest. We use prior information to construct prior distributions on the parameters of the input processes driving the simulation. Using Bayes' rule, we combine this prior information with the likelihood function of sample data observed on the input processes to compute the posterior parameter distributions. In our Bayesian simulation replication algorithm, we estimate parameter uncertainty by independently sampling new values of the input-model parameters from their posterior distributions on selected simulation runs; and we estimate stochastic uncertainty by performing multiple (conditionally) independent runs with each set of parameter values. We formulate performance measures relevant to both Bayesian and frequentist input-modeling techniques, and we summarize an experimental performance evaluation demonstrating the advantages of the Bayesian approach.
Economic and Performance Evaluation of Heat Sink Options in Combined Cycle Applications (2005)

This paper is a guideline to selecting the most appropriate technology for the power plant heat sink based on water availability, site location, and wastewater disposal requirements. The paper discusses wet as well as dry cooling systems and evaluates the impact of the heat sink technology on the performance and cost of combined cycle power plants. Cogeneration applications and cycling plant operations are also considered. For each proposed option, the performance, relative costs, and noise issues will be presented.
Neighbor Monitoring Mechanism to Solve Unidirectional Link Problem in MANET (2007)

Mobile ad hoc network (MANET) is a multihop wireless network formed by a collection of mobile nodes communicating through radio links characterized by the absence of any preexisting infrastructure. Many of the proposed on-demand routing algorithms for MANET assume that the given network is an undirected graph. Some modifications or new algorithms have been proposed to solve the unidirectional link problems. Those methods eliminate unidirectional links from the route computation procedure or cost overhead very much. This paper proposes a new scheme called NMM (neighbor monitoring mechanism) to solve the problems. The paper introduces the NMM mechanism, analyzes its performance and is compared with hello and blacklisting mechanism. Results show that the NMM mechanism is more effective than blacklisting mechanism and costs less overhead than hello mechanism.
Molecular structure and transformation of the glucose dehydrogenase gene in Drosophila melanogaster. (1988)

We have precisely mapped and sequenced the three 5' exons of the Drosophila melanogaster Gld gene and have identified the start sites for transcription and translation. The first exon is composed of 335 nucleotides and does not contain any putative translation start codons. The second exon is separated from the first exon by 8 kb and contains the Gld translation start codon. The inferred amino acid sequence of the amino terminus contains two unusual features: three tandem repeats of serine-alanine, and a relatively high density of cysteine residues. P element-mediated transformation experiments demonstrated that a 17.5-kb genomic fragment contains the functional and regulatory components of the Gld gene.
Process window and defect monitoring using high-throughput e-beam inspection guided by computational hot spot detection (2016)

As design rules for leading edge devices have shrunk to 1x nm size and below, device patterns have become sensitive to sub-10nm size defects. Additionally, defectivity and yield are now increasingly dominated by systematic patterning defects. A method for identifying and inspecting these hot spot (HS) locations is necessary for both technology development and High Volume Manufacturing (HVM). In order to achieve sufficient statistical significance across the wafer for a specific product and layer, a guided, high-speed e-beam inspection system is needed to cover a significant amount of high-volume hot spot locations for process window monitoring. In this paper, we explore the capabilities of a novel, highthroughput e-beam hot spot inspection tool, SkyScan<sup>TM</sup> 5000, on a 10nm back-end-of-line (BEOL) wafer patterned using a triple lithography-etch process. ASML’s high-resolution, design-aware computational hot spot inspection is used to identify relevant hot spot locations, including overlay-sensitive patterns. We guide the e-beam tool to these Points of Interest (POI) and obtain experimental data from inspection of 430k wafer locations. The large amount of data allows detection of wafer-level and intra-field defect signatures for a large number of hot spot patterns.
A direct comparison of immunological and clinical effects of interleukin 2 with and without interferon-alpha in humans. (1993)

Interleukin 2 (IL-2) and interferon-alpha (IFN-alpha) are cytokines with synergistic antitumor effects in mouse models. The biological effects of this combination, however, have not been directly compared to each agent alone in humans. We conducted a Phase 1B trial of IL-2 plus or minus IFN-alpha in 38 cancer patients. The objectives of this trial were to determine which doses of IFN-alpha and IL-2 maximally enhanced biological responses, and to determine whether the combined administration of IFN-alpha and IL-2 would result in a potentiation of biological responses over IL-2 alone. Patients received 4 days of IL-2 (1.5 x 10(6) units/m2/day or 3.0 x 10(6) units/m2/day) as a continuous infusion followed by a 3-day rest period, weekly for 3 weeks, with a 3-week rest period between 2 treatment courses. IFN-alpha (0.5 x 10(6) or 5 x 10(6) units/m2/day) was administered s.c. on days 1-4 weekly for 3 weeks with one of the 3-week courses. Patients were randomized to receive either IL-2 alone for course 1, followed by IL-2/IFN-alpha for course 2, or IL-2/IFN-alpha in course 1, followed by IL-2 alone. Immunological parameters were evaluated before treatment, and 24 h after completion of the third week of IL-2. A statistically significant increase in the percentage of circulating natural killer cells (CD56), natural killer cells bearing the Fc receptor (CD16), and activated T cells (CD25) was observed following IL-2 alone, and following IL-2 plus IFN-alpha. Significant increases in lymphocyte-activated killer cell cytotoxicity, antibody cellular cytotoxicity, and serum IL-2 receptor were also observed following both IL-2 and IL-2 plus IFN-alpha. However, no significant differences were observed in the magnitude of the increase in the IL-2-alone group when compared to the IL-2 plus IFN-alpha group. The mean fluorescent intensity of monocytes positive for HLA-DR and Fc receptor expression also increased significantly in both groups, as did serum beta 2-microglobulin expression and indoleamine 2,3-dioxygenase activity. However, increases were not significantly different between patients receiving IL-2 alone and IL-2 plus IFN-alpha. No dose response effect for IFN-alpha was observed for any of the parameters assessed. Toxicities consisted primarily of constitutional toxicities, including fever, rigors, malaise, headache, anorexia, and a decrease in performance status. No clinically significant differences in toxicities were observed between courses consisting of IL-2 and those consisting of IFN-alpha and IL-2.(ABSTRACT TRUNCATED AT 400 WORDS)
Differential Effects of Three Preparations of Human Serum on Expansion of Various Types of Human Cells (2008)

Serum from platelet-rich plasma, which is less invasive to prepare than serum from whole blood, was superior to serum from platelet-poor plasma as a substitute for animal-derived serum in culture expansion of dermal fibroblasts. Although autologous or human-derived serum preparations may be of great use in cell-based therapies, this usefulness strongly depends on the target cell species and the purpose of the cell culture.
A Novel Receptor-induced Activation Site in the Nipah Virus Attachment Glycoprotein (G) Involved in Triggering the Fusion Glycoprotein (F) (2008)

Cellular entry of paramyxoviruses requires the coordinated action of both the attachment (G/H/HN) and fusion (F) glycoproteins, but how receptor binding activates G to trigger F-mediated fusion during viral entry is not known. Here, we identify a receptor (ephrinB2)-induced allosteric activation site in Nipah virus (NiV) G involved in triggering F-mediated fusion. We first generated a conformational monoclonal antibody (monoclonal antibody 45 (Mab45)) whose binding to NiV-G was enhanced upon NiV-G-ephrinB2 binding. However, Mab45 also inhibited viral entry, and its receptor binding-enhanced (RBE) epitope was temperature-dependent, suggesting that the Mab45 RBE epitope on G may be involved in triggering F. The Mab45 RBE epitope was mapped to the base of the globular domain (beta6S4/beta1H1). Alanine scan mutants within this region that did not exhibit this RBE epitope were also non-fusogenic despite their ability to bind ephrinB2, oligomerize, and associate with F at wild-type (WT) levels. Although circular dichroism revealed conformational changes in the soluble ectodomain of WT NiV-G upon ephrinB2 addition, no such changes were detected with soluble RBE epitope mutants or short-stalk G mutants. Additionally, WT G, but not a RBE epitope mutant, could dissociate from F upon ephrinB2 engagement. Finally, using a biotinylated HR2 peptide to detect pre-hairpin intermediate formation, a cardinal feature of F-triggering, we showed that ephrinB2 binding to WT G, but not the RBE-epitope mutants, could trigger F. In sum, we implicate the coordinated interaction between the base of NiV-G globular head domain and the stalk domain in mediating receptor-induced F triggering during viral entry.
Regulación Valenciana de los Catálogos Municipales (2013)

Se recogen desde la normativa unos contenidos minimos para las fichas del catalogo y el establecimiento de un regimen transitorio de proteccion para los bienes que ya cuentan con la consideracion de bienes inmuebles de relevancia local, hasta la definitiva aprobacion de los correspondientes Catalogos Municipales de bienes y espacios protegidos configurados como instrumento de proteccion de los bienes que constituyen el patrimonio menor.
Parametric yield management for 3D ICs (2008)

Three-Dimensional (3D) Integrated Circuits (ICs) that integrate die with Through-Silicon Vias (TSVs) promise to continue system and functionality scaling beyond the traditional geometric 2D device scaling. 3D integration also improves the performance of ICs by reducing the communication time between different chip components through the use of short TSV-based vertical wires. This reduction is particularly attractive in processors where it is desirable to reduce the access time between the main logic die and the L2 cache or the main memory die. Process variations in 2D ICs lead to a drop in parametric yield (as measured by speed, leakage and sales profits), which forces manufacturers to speed bin their chips and to sell slow chips at reduced prices. In this paper we develop a model to quantify the impact of process variations on the parametric yield of 3D ICs, and then we propose a number of integration strategies that use a graph-theoretic framework to maximize the performance, parametric yield and profits of 3D ICs. Comparing our proposed strategies to current yield-oblivious methods, it is demonstrated that it is possible to increase the number of 3D ICs in the fastest speed bins by almost 2×, while simultaneously reducing the number of slow ICs by 29.4%. This leads to an improvement in performance by up to 6.45% and an increase of about 12.48% in total sales revenue using up-to-date market price models.
Low-Loss Almost Constant False-Alarm Rate Processors (1979)

Conventional normalizing constant false-alarm rate (CFAR) circuits use the same configurations when detecting targets in interference regions and in clear regions. The CFAR penalty incurred in the clear region can be reduced by using CFAR processors that recognize the region is clear so that normalization is not necessary. An analysis of the target-detection performance for a particular modified CFAR processor, for an active-radar sensor, and for a passive infrared (IR), or sonar, sensor is given. It is shown that the decreased CFAR penalty in the clear is coupled with an increase of false-alarm rate in the clutter regions.
Evolutionary relationship of thymopoietin to immunoglobulins and cellular recognition molecules. (1981)

The sequence of thymopoietin, a thymic hormone composed of 49 amino acids, was compared to sequences of immunoglobulins and related cellular recognition molecules. Maximum homology was found between an active site of thymopoietin and homologous regions of IgG, IgE, beta 2-microglobulin, HLA-B7 and the Thy-1 antigen predicted to mediate immunologic activities, including Fc receptor binding. These results suggest that thymopoietin may be derived from approximately one half of the ancestral domain common to immunoglobulins and related immune system molecules and provide further support for a general theory that predicts the location of active sites in molecules of the immune system.
A robust algorithm for Volt/Var control (2009)

This paper proposes an algorithm for Volt/VAr control, where the control variables are both discrete (tap position of on-load tap-changing, OLTC transformers, switched-on shunt capacitor banks), and continuous (reactive power of generators). The optimization criterion considered is minimization of the system real power losses, subject to nodal real and reactive power balances and nodal voltage constraints. The corresponding non-linear optimization problem is solved iteratively on two levels - the Volt sub-problem is mixed integer programming (MIP) based master problem and the Var sub-problem is the mixed integer linear programming (MILP) based problem. The MILP problem is solved by Benders decomposition (BD). The proposed optimization method is formulated for the case of the uncertain input network model parameters to assess robustness aspects. The effectiveness of the proposed robust model for Volt/Var control is verified on the test example of a reduced New England/New-York interconnection with 68 nodes/86 branches/23 OLTC transformers/16 generators/9 switchable capacitors.
Using video in the BNR usability lab (1989)

This paper describes the goals of the BNR Usability Lab and explains how we have achieved our goals by developing the "Co-Discovery Learning" testing methodology and designing "U-Test", a special interface for usability testing with video.
A Whisker Probe System for Shape Perception of Solids (1995)

A computer-controlled whisker probe system was designed to measure contours of solid objects. The system’s mechanical components include the whisker: a cantilevered spring steel wire instrumented with strain gages; and the whisker’s base sweep mechanism: an assembly of tubes that bend when pressurized. The base mechanism is programmed to sweep the whisker over a solid object, during which measures of whisker strain and tube pressure are combined with closed-loop control to compute and display the object’s shape. Experiments demonstrate the system’s precision and accuracy in measuring object boundaries. Future applications include whisker cluster systems mounted on mobile robots and programmed for robot obstacle avoidance.
RAMA: A Filesystem For Massively Parallel Computers (1993)

This paper describes a file system design for massively parallel computers which makes very efficient use of a few disks per processor. This overcomes the traditional I/O bottleneck of massively parallel machines by storing the data on disks within the high-speed interconnection network. In addition, the file system, called RAMA, requires little inter-node synchronization, removing another common bottleneck in parallel processor file systems. Support for a large tertiary storage system can easily be integrated into the file system
Local production of tumor necrosis factor alpha, interleukin 1, and interleukin 6 in meningococcal meningitis. Relation to the inflammatory response. (1989)

We examined the cerebrospinal fluid (CF) taken on admission from 60 patients with infections caused by Neisseria meningitidis for presence of TNF-alpha, IL-1, and IL-6. TNF-alpha was detected in CF in 55 and 19% (p = 0.03), IL-1 in 50 and 15% (p = 0.05), and IL-6 in 98 and 100% of patients with meningitis and septic shock/bacteremia, respectively. The median IL-6 concentration in CF in patients with meningitis was 154 ng/ml, and in patients with septic shock/bacteremia it was 42 ng/ml (p = 0.001). The level of LPS in CF correlated with the level of TNF-alpha (r = 0.91, p less than 0.001), but not with the level of IL-1 and IL-6. CF levels of TNF-alpha, IL-1, and IL-6 correlated with each other (r = 0.34-0.54, p less than 0.01), with the protein concentration (r = 0.34-0.62, p less than 0.01) and inversely with the CF/blood glucose ratio (r = -0.34 to -0.67, p less than 0.01). Only the Il-6 level correlated with the leukocyte count (r = 0.37, p less than 0.01). In rabbits TNF-alpha, IL-1, and IL-6 activities sequentially appeared in CF within 3 h of injection of meningococcal LPS or viable meningococci, whereas the main infiltration of granulocytes started after 4 h. TNF-alpha was detected in serum at concentrations less than 1/100 of those in CF after administration of LPS into the subarachnoid space, and conversely, TNF-alpha was detected in CF at concentrations 1/100 of those in serum after intravenous injection of LPS. The results demonstrate that TNF-alpha, IL-1, and IL-6 are sequentially produced in the initial phase of the local inflammatory response caused by meningococci, and that the subarachnoid space and systemic circulation are separate compartments with respect to production of TNF-alpha, IL-1, and IL-6.
The Effects of Exogenous Auxins on Endogenous Indole-3-Acetic Acid Metabolism (The Implications for Carrot Somatic Embryogenesis) (1996)

The effect of auxin application on auxin metabolism was investigated in excised hypocotyl cultures of carrot (Daucus carota). Concentrations of both free and conjugated indole-3-acetic acid (IAA), [2H4]IAA, 2,4-dichlorophenoxyacetic acid, and naphthaleneacetic acid (NAA) were measured by mass spectroscopy using stable-isotope-labeled internal standards. [13C1]NAA was synthesized for this purpose, thus extending the range of auxins that can be assayed by stable-isotope techniques. 2,4-Dichlorophenoxyacetic acid promoted callus proliferation of the excised hypocotyls, accumulated as the free form in large quantities, and had minor effects on endogenous IAA concentrations. NAA promoted callus proliferation and the resulting callus became organogenic, producing both roots and shoots. NAA was found mostly in the conjugated form and had minor effects on endogenous IAA concentrations. [2H4]IAA had no visible effect on the growth pattern of cultured hypocotyls, possibly because it was rapidly metabolized to form inactive conjugates or possibly because it mediated a decrease in endogenous IAA concentrations by an apparent feedback mechanism. The presence of exogenous auxins did not affect tryptophan labeling of either the endogenous tryptophan or IAA pools. This suggested that exogenous auxins did not alter the IAA biosynthetic pathway, but that synthetic auxins did appear to be necessary to induce callus proliferation, which was essential for excised hypocotyls to gain the competence to form somatic embryos.