gebhart/patrepeval huggingface dataset:
Intracellular Processing of CFTR (2005)

The cystic fibrosis transmembrane conductance regulator (CFTR or ABCC7), a cAMP-regulated plasma membrane chloride channel, belongs to the ATP-binding cassette (ABC) transporter superfamily. Cystic fibrosis (CF) mutations could be grouped into three major categories based on their cellular/ biochemical phenotype: impaired CFTR production, function and cell surface stability, or a combination of these. Each of these mechanisms can be attributed to a variety of molecular defects. Since the majority of the mutations, including the most common deletion phenylalanine 508 (ΔF508 CFTR), result in premature degradation of the channel at the endoplasmic reticulum, significant efforts have been devoted to relocate the mutant, but functional CFTR to the cell surface in an attempt to alleviate the CF phenotype.To increase the rescue efficiency of the trafficking defects and unravel the cellular and molecular basis of CF, it is imperative to understand the principles that govern the biogenesis, trafficking, and degradation of CFTR. Here we provide a brief overview of recent progress regarding the cellular processing of CFTR and some highlights of its perturbations caused by clinically relevant mutations.
Gabor Analysis and Algorithms: Theory and Applications (1997)

The duality condition for Weyl-Heisenberg frames, A.J.E.M. Janssen Gabor systems and the Balian-Low theorem, John J. Benedetto et al A Banach space of test functions for Gabor analysis, Hans G. Feichtinger, Georg Zimmermann Pseudodifferential operators, Gabor frames, and local trigonometric bases, Richard Rochberg, Kazuya Tachizawa Perturbation of frames and applications to gabor frames, Ole Christensen aspects of Gabor analysis on locally compact abelian groups, Karlheinz Grochenig Quantization of TF lattice-invariant operators on elementary LCA groups, Hans G. Feichtinger, Werner Kozek Numerical algorithms for discrete Gabor expansions, Thomas Strohmer Oversampled modulated filter banks, Helmut Bolcskei, Franz Hlawatsch Adaptation of Weyl-Heisenberg frames to underspread environments, werner Kozek gabor representation and signal detection, Ariela Zeira, Benjamin Friedlander Multi-window Gabor schemes in signal and image representations, Yoshua Y. Zeevi et al Gabor kernels for affine-invariant object recognition, Jezekiel Ben-Arie, Zhiqian Wang Gabor's signal expansion in optics, Martin J. Bastiaans.
Determining Hydrogen in Gases with a Thermal-Conductivity Apparatus (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermining Hydrogen in Gases with a Thermal-Conductivity ApparatusG A. Webb and G S. BlackCite this: Ind. Eng. Chem. Anal. Ed. 1944, 16, 11, 719–720Publication Date (Print):November 1, 1944Publication History Published online1 May 2002Published inissue 1 November 1944https://pubs.acs.org/doi/10.1021/i560135a018https://doi.org/10.1021/i560135a018research-articleACS PublicationsRequest reuse permissionsArticle Views25Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo (1993)

The racemic triflate derivatives 5-8 of the 5-, 6-, 7-, and 8-hydroxylated 2-(di-n-propylamino)-teralins 1-4 were shown to possess similar pharmacological profiles to their phenolic counterparts in in vitro binding and in vivo biochemical and behavioral assays in rats. Consequently, subcutaneous administration of the 5-, 6-, and 7-triflates displayed essentially dopaminergic agonist properties, while the 8-triflate was shown to be a selective 5-HT1A receptor agonist. With respect to their agonist activities, the triflates were less potent than their phenolic analogs. The absolute oral bioavailability of compound 8 (8-triflate) was 4-5 times greater than the corresponding hydroxylated compound. Interestingly, in the in vivo biochemical assay compound 8 was found to be more potent after oral than after subcutaneous administration, indicating formation of one or more active metabolites. Following a study of the metabolism of compound 8 in rat hepatocytes, the monopropyl analog 9 was identified as the major metabolite and was surprisingly found to be more potent than compound 8. Oral administration of compound 5 (5-triflate) resulted in behavioral and biochemical effects indicative of mixed DA/5-HT1A agonist properties not seen after subcutaneous administration. These results may also be indicative of the formation of active metabolites.
Complement activation in hidradenitis suppurativa: a new pathway of pathogenesis? (2018)

Systemic complement activation occurs in HS and may be used as a surrogate biomarker of HS. C5a stimulates overproduction of TNF-α and may be a future therapeutic target.
Properties of Electrolytic Solutions. XIV. The Dielectric Constant of Some Solutions of Electrolytes in Benzene<sup>1</sup> (1934)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProperties of Electrolytic Solutions. XIV. The Dielectric Constant of Some Solutions of Electrolytes in Benzene1Gilman S. Hooper and Charles A. KrausCite this: J. Am. Chem. Soc. 1934, 56, 11, 2265–2268Publication Date (Print):November 1, 1934Publication History Published online1 May 2002Published inissue 1 November 1934https://pubs.acs.org/doi/10.1021/ja01326a017https://doi.org/10.1021/ja01326a017research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The ORF3 Protein of Hepatitis E Virus Binds to Src Homology 3 Domains and Activates MAPK (2001)

The hepatitis E virus (HEV) is the causative agent of hepatitis E, an acute form of viral hepatitis. The biology and pathogenesis of HEV remain poorly understood. We have used in vitro binding assays to show that the HEV ORF3 protein (pORF3) binds to a number of cellular signal transduction pathway proteins. This includes the protein tyrosine kinases Src, Hck, and Fyn, the p85alpha regulatory subunit of phosphatidylinositol 3-kinase, phospholipase Cgamma, and the adaptor protein Grb2. A yeast two-hybrid assay was used to further confirm the pORF3-Grb2 interaction. The binding involves a proline-rich region in pORF3 and the src homology 3 (SH3) domains in the cellular proteins. Competition assays and computer-assisted modeling was used to evaluate the binding surfaces and interaction energies of the pORF3.SH3 complex. In pORF3-expressing cells, pp60(src) was found to associate with an 80-kDa protein, but no activation of the Src kinase was observed in these cells. However, there was increased activity and nuclear localization of ERK in the pORF3-expressing cells. These studies suggest that pORF3 is a viral regulatory protein involved in the modulation of cell signaling. The ORF3 protein of HEV appears to be the first example of a SH3 domain-binding protein encoded by a virus that causes an acute and primarily self-limited infection.
Synergistic Effects in Sonochemical Sterilization (1967)

The synergistic effects observed during the sterilization of Bacillus subtilis var. niger ATCC 9372 by the combined action of ethylene or propylene oxide with high-intensity airborne sound waves (34.8 kc/sec) were investigated. It has been shown that the number of surviving spores deposited on paper strips decreases exponentially with the sound intensity at sample level. Reductions of the order of one-third of the time required for standard propylene oxide sterilization have been observed by using the combined action of sound waves with gaseous sterilization. At the present time, maximal synergistic effects seem to be achieved for the following experimental conditions: propylene oxide concentration, 500 to 1,000 mg/liter; acoustic intensity, 161 to 162 db; contact time, 80 min; temperature, 60 C; and relative humidity, 40%. The basic mechanism involved in sonochemical sterilization seems to be more of a physical (accelerated gas diffusion) than a chemical nature.
A 2 W, high efficiency, 2-8 GHz, cascode HBT MMIC power distributed amplifier (2002)

In this paper a new topology for wideband power distributed amplifiers is proposed. This topology is based on a nonlinearly optimized HBT cascode cell. More than 2 W have been measured in the 2-8 GHz frequency range with an associated gain of 9 dB and a PAE higher than 20%. Those results have been found in good agreement with the simulated ones.
Fiber Nonlinearity Limitations in Ultra-Dense WDM Systems (2004)

Transmission performance of ultra-dense 2.5- and 10-Gb/s nonreturn-to-zero intensity-modulated direct-detection wavelength-division-multiplexing systems in various single-mode fibers is investigated. Fundamental limiting factors and their remedies by using optimum dispersion compensation for periodically amplified systems in C band are presented.
Continuous-Camiotee Phasing: An Advanced Valve-Tirning Approach (1987)

<div class="htmlview paragraph">VARIABLE-VALVE TIMING ALLOWS for controlled scheduling of valve-timing events. When applied to spark-ignition engines, it yields improvements in emissions, economy, and performance. The benefits for diesel engines further include: improved starting, noise reduction, and the ability to vary compression ratios. A <u>camlobe</u>-phasing system which takes advantage of the merits of variable-valve timing has been developed. Some advantages of this advanced valve-timing approach are: <ol class="list nostyle"> <li class="list-item"> <span class="li-label">1.</span> <div class="htmlview paragraph">continuous control over valve-timing events,</div></li> <li class="list-item"> <span class="li-label">2.</span> <div class="htmlview paragraph">independent control over valve opening and closing times, and</div></li> <li class="list-item"> <span class="li-label">3.</span> <div class="htmlview paragraph">its application to engines with single-or twin-camshaft arrangements.</div></li></ol></div>
Local Difference Binary for Ultrafast and Distinctive Feature Description (2013)

The efficiency and quality of a feature descriptor are critical to the user experience of many computer vision applications. However, the existing descriptors are either too computationally expensive to achieve real-time performance, or not sufficiently distinctive to identify correct matches from a large database with various transformations. In this paper, we propose a highly efficient and distinctive binary descriptor, called local difference binary (LDB). LDB directly computes a binary string for an image patch using simple intensity and gradient difference tests on pairwise grid cells within the patch. A multiple-gridding strategy and a salient bit-selection method are applied to capture the distinct patterns of the patch at different spatial granularities. Experimental results demonstrate that compared to the existing state-of-the-art binary descriptors, primarily designed for speed, LDB has similar construction efficiency, while achieving a greater accuracy and faster speed for mobile object recognition and tracking tasks.
Low Level Light Therapy Modulates Inflammatory Mediators Secreted by Human Annulus Fibrosus Cells during Intervertebral Disc Degeneration <i>In Vitro</i> (2015)

Intervertebral disc degeneration (IVD) is one of the important causes of low back pain and is associated with inflammation induced by interaction between macrophages and the human annulus fibrosus (AF) cells. Low-level light therapy (LLLT) has been widely known to regulate inflammatory reaction. However, the effect of LLLT on macrophage-mediated inflammation in the AF cells has not been studied till date. The aim of this study is to mimic the inflammatory microenvironment and to investigate the anti-inflammatory effect of LLLT at a range of wavelengths (405, 532 and 650 nm) on the AF treated with macrophage-like THP-1 cells conditioned medium (MCM) containing proinflammatory cytokines and chemokines (interleukin-1beta, tumor necrosis factor-alpha, interleukin-6 and 8). We observed that AF cells exposed to MCM secrete significantly higher concentrations of IL-6, IL-8, IL-1β and TNF-α. LLLT markedly inhibited secretion of IL-6 at 405 nm in a time-dependent manner. Level of IL-8 was significantly decreased at all wavelengths in a time-dependent manner. We showed that MCM can induce the inflammatory microenvironment in AF cells and LLLT selectively suppressed IL-6 and 8 levels. The results indicate that LLLT is a potential method of IVD treatment and provide insights into further investigation of its anti-inflammation effect on IVD.
A new algorithm for estimating mobile speed at the TDMA-based cellular system (2002)

This paper presents a study on the technique of estimating mobile speed in the TDMA-based GSM network. Two algorithms are proposed. They estimate the mobile speed based on the variation of the received signal envelope cross each burst due to fast fading. Hence they are suitable for both FH (frequency hopping) and non-FH cases. Computer simulations have been done to evaluate the performance by using these two algorithms.
Impermeant maleimides. Oriented probes of erythrocyte membrane proteins. (1976)

Maleimides impermeant to human erythrocyte membranes have been synthesized and applied to studies of the sulfhydryl groups of the membrane. Reaction of radioactive dextran-maleimide and glutathione-maleimide with either intact erythrocytes or ghosts yields sulfhydryl titers for the outer (exofacial) and inner (endofacial) surfaces, respectively, of 1.5 to 1.7 and 27 to 28 amol/cell. Corresponding values for sulfhydryl groups within the membrane interior, as estimated with radioactive N-ethylmaleimide, are 16 to 22 amol/cell. After exofacial labeling of intact cells with [35S]glutathione-maleimide, autoradiography of sodium dodecyl sulfate-polyacrylamide gels demonstrates four bands (alpha, beta, gamma, and delta) containing, respectively, 13%, 63%, 11%, and 13% of the radioactivity. The major beta-band corresponds in position to polypeptides of molecular weight 40,000 to 70,000 and to Coomassie brilliant blue-stained Band 5. Selective extraction demonstrates that the major Band 5 protein is not identical with the labeled beta-band polypeptides. Following endofacial labeling of ghosts with [35S]glutathione-maleimide, autoradiography reveals radioactivity in all of the major Coomassie brilliant blue bands. The impermeant maleimides described are also applicable to studies of discrete functional proteins of the erythrocyte membrane, including the hexose transport mechanism and the major Rho antigenic site.
Von der Form zur Bedeutung: Texte automatisch verarbeiten - From Form to Meaning: Processing Texts Automatically (2009)

<veb:p>The book contains the papers presented at the 2009 bi-annual conference of the German Society for Computational Linguistics and Language Technology (GSCL), as well as those of the associated 2nd UIMA@GSCL workshop. The main theme of the conference was computational approaches to text processing, and in conjunction with the UIMA (Unstructured Information Management Architecture) workshop, this volume offers an overview of current work on both theoretical and practical aspects of text document processing.</veb:p> <veb:p/>
Biochemistry and molecular genetics of cell‐wall lipid biosynthesis in mycobacteria (1997)

Tuberculosis and other mycobacterial infections are the most serious infectious diseases in terms of human fatalities. The high content of unique cell-wall lipids helps these organisms to resist antimicrobial drugs and host defences. The biosynthesis of these lipids is discussed briefly. The recent advances in recombinant DNA technology have begun to help to elucidate the nature of some of the enzymes involved in this process and the genes that encode them. Gene disruption and other molecular genetic technologies are beginning to provide new approaches to test for the biological functions of these gene products and may lead to identification of new antimycobacterial drug targets.
Ultrathin molecularly imprinted polymer sensors employing enhanced transmission surface plasmon resonance spectroscopy (2006)

An ultrathin novel nanosensor (31.5 +/- 4.1 nm thick in the absence of analytes), employing a molecularly imprinted polymer as a recognition element for cholesterol and gold nanoparticle enhanced transmission surface plasmon resonance spectroscopy for detection, was constructed.
Multicenter clinical study on Fuzhenghuayu capsule against liver fibrosis due to chronic hepatitis B (2005)

Fuzhenghuayu capsule has good therapeutic effects on alleviating liver fibrosis due to chronic hepatitis B without any adverse effect and is superior to that of Heluoshugan capsule.
Detection of Favorable QTL Alleles and Candidate Genes for Lint Percentage by GWAS in Chinese Upland Cotton (2016)

Improving cotton yield is a major breeding goal for Chinese upland cotton. Lint percentage is an important yield component and a critical economic index for cotton cultivars, and raising the lint percentage has a close relationship to improving cotton lint yield. To investigate the genetic architecture of lint percentage, a diversity panel consisting of 355 upland cotton accessions was grown, and the lint percentage was measured in four different environments. Genotyping was performed with specific-locus amplified fragment sequencing (SLAF-seq). Twelve single-nucleotide polymorphisms (SNPs) associated with lint percentage were detected via a genome-wide association study (GWAS), in which five SNP loci distributed on chromosomes A<sub>t</sub>3 (A02) and A<sub>t</sub>4 (A08) and contained two major-effect QTLs, which were detected in the best linear unbiased predictions (BLUPs) and in more than three environments simultaneously. Furthermore, favorable haplotypes (FHs) of two major-effect QTLs and 47 putative candidate genes in the two linkage disequilibrium (LD) blocks of these associated loci were identified. The expression levels of these putative candidate genes were estimated using RNA-seq data from ten upland cotton tissues. We found that <i>Gh_A02G1268</i> was very highly expressed during the early fiber development stage, whereas the gene was poorly expressed in the seed. These results implied that <i>Gh_A02G1268</i> may determine the lint percentage by regulating seed and fiber development. The favorable QTL alleles and candidate genes for lint percentage identified in this study will have high potential for improving lint yield in future Chinese cotton breeding programs.
Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views (2020)

Wnt signaling governs tissue development, homeostasis, and regeneration. However, aberrant activation of Wnt promotes tumorigenesis. Despite the ongoing efforts to manipulate Wnt signaling, therapeutic targeting of Wnt signaling remains challenging. In this review, we provide an overview of current clinical trials to target Wnt signaling, with a major focus on gastrointestinal cancers. In addition, we discuss the caveats and alternative strategies for therapeutically targeting Wnt signaling for cancer treatment.
Microstructural characterization of sol–gel lead–zirconate–titanate thin films (1998)

The techniques of x-ray diffraction, x-ray photoelectron spectroscopy (XPS), Auger analysis, and transmission and scanning transmission electron microscopy (TEM) have been applied to the analysis of thin films of Pb(Zr0.30Ti0.70)O3 (PZT30/70) deposited at low temperatures (510 °C) by a sol–gel process onto Pt/Ti electrodes on SiO2/Si 100 substrates. It is found that the platinum film is highly oriented with the [111] axis perpendicular to the substrate plane. The ferroelectric film tends to crystallize epitaxially upon this as columnar crystals. There are indications from the TEM of the existence of a second metallic phase at the interface between the platinum and the PZT30/70 film, which may be associated with its nucleation. The TEM shows the boundaries between the individual sol–gel layers, although the growing crystallites of the PZT30/70 propagate through these boundaries unhindered. The XPS and Auger analyses have shown that Pb penetrates through the Pt layer to the underlying Ti layer, even at the low crystallization temperatures used. There is also clear evidence for diffusion of the Zr and Ti prior to, or during the crystallization process, so that the Zr migrates to the surface of each sol–gel layer. The effects of using different crystallization processes on this compositional separation and the reasons for its occurrence are discussed, as are the possible effects upon macroscopically measured ferroelectric properties.
Mitigating Intensity Bias in Shadow Detection via Feature Decomposition and Reweighting (2021)

Although CNNs have achieved remarkable progress on the shadow detection task, they tend to make mistakes in dark non-shadow regions and relatively bright shadow regions. They are also susceptible to brightness change. These two phenomenons reveal that deep shadow detectors heavily depend on the intensity cue, which we refer to as intensity bias. In this paper, we propose a novel feature decomposition and reweighting scheme to mitigate this intensity bias, in which multi-level integrated features are decomposed into intensity-variant and intensity-invariant components through self-supervision. By reweighting these two types of features, our method can reallocate the attention to the corresponding latent semantics and achieves balanced exploitation of them. Extensive experiments on three popular datasets show that the proposed method outperforms state-of-the-art shadow detectors.