gebhart/patrepeval huggingface dataset:
Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions (2016)

Previous studies have suggested that NK cells may limit T cell responses by their ability to eradicate dendritic cells, as demonstrated by NK cell-mediated killing of dendritic cells generated from mouse bone marrow cells or human monocytes with GM-CSF. In the present study, we demonstrated that conventional dendritic cells, generated in vitro with Flt3 ligand or from spleens, were resistant to NK cell-mediated lysis. However, upon stimulation with GM-CSF, NK cells could mediate lysis of these dendritic cells. GM-CSF-stimulated Flt3 ligand dendritic cells or splenic dendritic cells increased surface expression of costimulatory molecules and known NK cell ligands. Likewise, NK cells could target dendritic cells in vivo, which could be inhibited, in part, by anti-GM-CSF antibodies. The blocking of CD54 or CD226 inhibited NK cell-mediated cytotoxicity of the GM-CSF-stimulated Flt3 ligand conventional dendritic cells. Furthermore, the CD226<sup>+</sup>NKG2A<sup>-</sup> subset of NK cells was selectively better at targeting GM-CSF-stimulated Flt3 ligand conventional dendritic cells. However, CD155, a known ligand for CD226, could also act as an inhibitor of NK cell-mediated lysis, as dendritic cells lacking CD155 were more sensitive to NK cell-mediated lysis than wild-type dendritic cells. We hypothesize that by only permitting a subset of NK cells to target activated dendritic cells during inflammation, this would allow the immune system to balance between dendritic cells able to drive adaptive immune responses and dendritic cells targeted for elimination by NK cells to hinder, e.g., spread of infection.
A Broadband Injection-Locking Class-E Power Amplifier (2012)

This paper presents a fully integrated two-stage injection-locking class-E power amplifier (PA) using a GaAs 0.5-μm enhancement- and depletion-mode pseudomorphic high-electron mobility transistor (E/D-mode PHEMT) process. The injection-locking concept is used in this design, and the PA works as an oscillator whose output voltage is tuned at the input frequency. The proposed PA achieves high power-added efficiency (PAE) and high power gain. An autonomous circuit is also employed for the stability analysis, and the design procedure is summarized for the circuit implementation. By employing this design technique, the proposed injection-locking class-E PA under continuous-wave signal achieves a peak PAE of 59% at an output power of 26.6 dBm from a 6-V dc supply voltage. With a Gaussian minimum-shift keying (GMSK) modulation input signal at 3.5 GHz, the measured maximum PAE is 57% at an output power of 26.7 dBm. The measured error vector magnitude is within 2.2% over all of the output power level, and the adjacent channel power ratio is better than - 40 dBc. Under a 64-QAM modulation signal with class-AB operation, the proposed PA achieves a peak PAE of 55% with an output power of 27 dBm.
A linear method for determining liver sinusoidal and extravascular volumes (1963)

Multiple indicator dilution studies of the hepatic circulation in the dog were carried out using labeled red cells, albumin, inulin, sucrose, sodium, urea, water, and T-1824. The materials were completely recovered in the outflow. Concentrations were expressed as fractions of the injected mass. The outflow pattern of each of the substances was displaced relative to the red cell curve, showing a lower peak concentration and longer transit time. The displacement was largest for water and urea, least for albumin and T-1824, intermediate for inulin, sucrose, and sodium. The results were analyzed using a flow-limited linear two-compartment model system. The analysis yielded estimates of sinusoidal blood volume and of the extravascular volumes of distribution of the diffusible labels. Water and urea volumes agreed with the liver weights and this agreement was taken as validation of the method of analysis. Volumes calculated for the other presumably extracellular substances demonstrated that the rapidly available extracellular space diminishes with increase in the molecular weight of the substance.
Depot perphenazine decanoate and enanthate for schizophrenia (2005)

Depot perphenazine is in clinical use in the Nordic countries, Belgium, Portugal and the Netherlands. At a conservative estimate, a quarter of a million people suffer from schizophrenia in those countries and could be treated with depot perphenazine. The total number of participants in the four trials with useful data is 313. None of the studies observed the effects of oral versus depot antipsychotic drugs. Until well conducted and reported randomised trials are undertaken clinicians will be in doubt as to the effects of perphenazine depots and people with schizophrenia should exercise their own judgement or ask to be randomised.
A Hierarchical Power-saving Method of WUSB over WBAN (2013)

In this paper, an IEEE 802.15.6 wireless body area networks (WBAN) medium access control protocol is developed to support a wireless USB (WUSB) application as a protocol adaptation layer (PAL). Due to portable and wearable nature, the WUSB over IEEE 802.15.6 hierarchical medium access control (MAC) protocol has to support the power saving operation and integrate WUSB transactions with WBAN traffic efficiently. In this paper, we propose a Hierarchical Power-saving Method (HPM) for WUSB over IEEE 802.15.6 hierarchical MAC to improve its energy efficiency. Simulation results show that the HPM also integrate WUSB transactions and WBAN traffic efficiently while it achieves high energy efficiency.
Interactions of nucleotides, polynucleotides, and nucleic acids with dihydroxyboryl-substituted celluloses (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteractions of nucleotides, polynucleotides, and nucleic acids with dihydroxyboryl-substituted cellulosesM. Rosenberg, J. L. Wiebers, and P. T. GilhamCite this: Biochemistry 1972, 11, 19, 3623–3628Publication Date (Print):September 12, 1972Publication History Published online1 May 2002Published inissue 12 September 1972https://pubs.acs.org/doi/10.1021/bi00769a020https://doi.org/10.1021/bi00769a020research-articleACS PublicationsRequest reuse permissionsArticle Views175Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Climate of Change: The ABC as Patron of Australian Music during the Hopkins Era (2003)

The appointment of the English conductor and administrator John Hopkins as Federal Director of Music in 1963 coincided with the belated arrival of musical modernism to Australia and the concomitant emergence of young composers sympathetic to its tenets. With considerable vision and courage, Hopkins scheduled regular performances of their music at these concerts and conducted many premieres himself. In this way, he gave significant impetus to their careers and, at the same time, created an awareness that Australians could write effective concert-hall music. This article traces the various currents extant in music at the time and interprets the era of Hopkins's tenure with a perspective possible with the passing of modernism towards the end of the century.
Real-Time Optimization for Power Management Systems of a Battery/Supercapacitor Hybrid Energy Storage System in Electric Vehicles (2014)

Batteries mounted on electric vehicles (EVs) are often damaged by high peak power and rapid charging/discharging cycles, which are originated from repetitive acceleration/deceleration of vehicles particularly in urban situations. To reduce battery damage, the battery/supercapacitor (SC) hybrid energy storage system (HESS) has been considered as a solution because the SC can act as a buffer against large magnitudes and rapid fluctuations in power. While the traditional purpose of employing the HESS in EVs is to minimize the magnitude/variation of battery power or power loss, the previous approaches proposed for controlling the HESS have some drawbacks; they neither consider these objectives simultaneously nor reflect real-time load dynamics for computing the SC reference voltage. In this paper, we present a power control framework consisting of two stages: one for computing the SC reference voltage and another for optimizing the power flowing through the HESS. In the presented framework, we propose a methodology for calculating the SC reference voltage considering the real-time load dynamics without given future operation profiles. In addition, we formulate the HESS power control problem as a convex optimization problem that minimizes the magnitude/fluctuation of battery power and power loss at the same time. The optimization problem is formulated so that it can be repeatedly solved by general solvers in polynomial time. Simulation results carried out on MATLAB show that the magnitude/variation of battery power and power loss can be concurrently reduced in real time by the proposed framework.
Structural protein analysis of the polyvalent staphylococcal bacteriophage 812 (2006)

Phage 812 is a polyvalent phage with a very broad host range in the genus Staphylococcus, which makes it a suitable candidate for phage therapy of staphylococcal infections. This proteomic study, combining the results of both 1-DE and 2-DE followed by PMF, led to the identification of 24 virion proteins. Twenty new proteins, not yet identified by proteome analysis of closely related staphylococcal phages K and G1 were identified using this approach. Fifteen proteins were assigned unambiguously to the head-tail genome module; the remaining nine proteins are encoded by genes of the left or right arms of the phage genome. As expected, the most abundant proteins in the electrophoretic patterns are the major capsid protein, the major tail sheath protein and proteins identical to ORF 50 and ORF 95 of phage K, although their function is only putative. Identification of these 20 new proteins contributes substantially to a detailed characterization of phage virions, knowledge of which is necessary for rational phage therapy.
Intranasal mucoadhesive microemulsions of zolmitriptan: Preliminary studies on brain-targeting (2005)

The aim of this investigation was to prepare microemulsions containing zolmitriptan (ZT) for rapid drug delivery to the brain to treat acute attacks of migraine and to characterize microemulsions and evaluate biodistribution in rats. Zolmitriptan microemulsions (ZME) were prepared using the titration method and were characterized for globule size distribution and zeta potential. ZT was radiolabeled using (99m)Tc (technetium) and radiolabeled-drug formulations of ZT were used to carry out biodistribution of drug in the brain of Swiss albino rats after intranasal and intravenous administration. The pharmacokinetic parameters, drug targeting efficiency (%DTE) and direct nose-to-brain drug transport (%DTP) were calculated. Brain scintigraphy imaging in rats were also performed to ascertain the uptake of drug into the brain. ZME were transparent and stable with mean globule size of 35 +/- 25 nm and zeta potential of - 38- - 52 mV. (99m)Tc-labeled-drug formulations of ZT were found to be stable and suitable to perform in vivo studies. Following intranasal administrations of zolmitriptan mucoadhesive microemulsion (ZMME), ZME, Zolmitriptan solution (ZS) and intravenous administration of ZS, brain/blood uptake ratios at 0.50 h were found to be 0.70, 0.56, 0.27 and 0.13, respectively, indicating effective brain-targeting following intranasal administration of ZMME. Comparing intranasal administration of ZMME with intravenous administration of ZME, the %DTE and %DTP were found higher indicating effective drug transport following intranasal administration and highest brain-targeting following ZMME administration. Rat brain scintigrams showed substantial uptake of drug into the brain after intranasal administration of ZMME. Studies of this investigation conclusively demonstrated rapid and larger extent of transport into the rat brain following intranasal administration of ZMME and can play a promising role in the treatment of acute attacks of migraine.
Low thermal resistance flip-chip bonding of 850 nm 2-D VCSEL arrays capable of 10 Gbit/s/ch operation (2004)

In this work, 8/spl times/8 and 4/spl times/8 arrays of 850 nm oxide-confined VCSELs with 250 /spl mu/m device pitch are directly hybridized onto silicon fanout chips by means of an indium solder based flip-chip technology. Using this structure, digital data transmission experiments are conducted, which demonstrates that quasi error-free (bit error rate <10/sup -12/) 10 Gbit/s transmission can be achieved.
An Analysis of the Hysteresis Motor II-The Circumferential-Flux Machine (1964)

Part I of this paper presented an analysis of an idealized polyphase hysteresis machine having a radial-flux type of rotor. In this Part II, a hysteresis machine with a circumferential-flux type of rotor is analyzed. Using a rectangular loop approximation to the B-H characteristic of the hysteresis material, the flux density distribution in the machine is found and an equivalent circuit is developed. An improved model of the B-H loop is then used, and two approximate analyses are developed for this improved representation of the machine.
What can machine learning do? Workforce implications (2017)

Profound change is coming, but roles for humans remain
Transition Metal Catalyzed Acetic Acid Synthesis from Methane and CO (1992)

Abstract Methane reacts with CO to give acetic acid in good yield by the CuSO4 and/or Pd(OCOEt)2 catalysts via C-H bond activation. This reaction has an advantage over the method which uses methanol and rhodium catalysts, in that cheap methane and copper catalysts can be used. Propane also reacts with CO to give butyric acids.
Approximation Methods for Thin Plate Spline Mappings and Principal Warps (2002)

The thin plate spline (TPS) is an effective tool for modeling coordinate transformations that has been applied successfully in several computer vision applications. Unfortunately the solution requires the inversion of a p × p matrix, where p is the number of points in the data set, thus making it impractical for large scale applications. In practical applications, however, a surprisingly good approximate solution is often possible using only a small subset of corresponding points. We begin by discussing the obvious approach of using this subset to estimate a transformation that is then applied to all the points, and we show the drawbacks of this method. We then proceed to borrow a technique from the machine learning community for function approximation using radial basis functions (RBFs) and adapt it to the task at hand. Using this method, we demonstrate a significant improvement over the naive method. One drawback of this method, however, is that is does not allow for principal warp analysis, a technique for studying shape deformations introduced by Bookstein based on the eigenvectors of the p × p bending energy matrix. To address this, we describe a third approximation method based on a classic matrix completion technique that allows for principal warp analysis as a by-product. By means of experiments on real and synthetic data, we demonstrate the pros and cons of these different approximations so as to allow the reader to make an informed decision suited to his or her application. I.
Low-threshold lasers fabricated by alignment-free impurity induced disordering (1993)

An Si/SiN/sub x//Si trilayer diffusion source and mask is described and applied to an alignment-free process for fabricating lasers by impurity-induced disordering (IID). Edge-emitting lasers with continuous wave threshold currents of 4.8 mA were achieved, and folded-cavity surface-emitting lasers with Si disordered waveguides were demonstrated for the first time with a threshold of 11 mA. The process that makes possible self-aligned-metallization on a diffusion defined stripe will be useful in fabricating narrow stripe IID lasers and simplify processing for integration of IID waveguide devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Evaluation of Peroxisomal Heme in Yeast (1997)

Heme is supposed to be transported into peroxisomes to form peroxisomal catalase [EC 1.11.1.6] in harmony with proliferation of the organelle because of the absence of the heme synthetic pathway in peroxisomes. We tried to understand the transport mechanism of peroxisomal catalase through the peroxisomal membrane from the aspects of a cofactor, heme, by measuring cellular and subcellular heme contents with the pyridine hemochrome method, independent of measuring the catalase activity. n-Alkane-grown Candida tropicalis cells, in which peroxisomes develop profusely, contained a larger amount of heme than the glucose-grown cells, and the increase well matched that of the catalase activity. The results of subcellular fractionation of the n-alkane-grown cells showed that, in peroxisomes, the catalase subunit and heme existed in a molar ratio of 1:1, indicating that excessively transported catalase subunit proteins or heme could not be present in peroxisomes and they formed a tetramer having four molecules of heme. From this quantification of peroxisomal heme, it was strongly suggested that the amounts of the catalase subunit protein and heme transported into peroxisomes should be stoichiometrically regulated at the step of their synthesis or/and transport.
Intensity modulation and chirp of 1.55-/spl mu/m multiple-quantum-well laser diodes: modeling and experimental verification (1999)

A laser model based on rate equations for the simulation of high-speed optical access networks using directly modulated lasers is presented. The laser model is implemented into a commercial microwave simulator (Microwave Design System (MDS), Hewlett Packard). The extraction of DC- and small-signal RF parameters of the laser is described. The laser model is verified by the very good agreement of simulated and measured large-signal intensity and chirp waveforms. Model validity is further confirmed by comparing measured and simulated 10-Gbit/s eye diagrams after up to 100 km of standard fiber.
Dotplot: A Program for Exploring Self-Similarity in Millions of Lines of Text and Code (1993)

Abstract An interactive program, dotplot, has been developed for browsing millions of lines of text and source code, using an approach borrowed from biology for studying homology (self-similarity) in DNA sequences. With conventional browsing tools such as a screen editor, it is difficult to identify structures that are too big to fit on the screen. In contrast, with dotplots we find that many of these structures show up as diagonals, squares, textures, and other visually recognizable features, as will be illustrated in examples selected from biology and two new application domains, text (AP news, Canadian Hansards) and source code (5ESS®). In an attempt to isolate the mechanisms that produce these features, we have synthesized similar features in dotplots of artificial sequences. We also introduce an approximation that makes the calculation of dotplots practical for use in an interactive browser. Key Words: BiologyCorporaDuplicationScatterplotSoftware engineeringString matching
The thermal expansion of graphite: part II. Theoretical (1945)

A theory of the thermal expansion of hexagonal crystals is derived, and shown to account quantitatively for the experimental data on graphite. Certain of the elastic moduli for graphite are estimated, and are at 18°c. approximately: s11+s12= 1.8×10-13 cm./dyne s13=-4.3×10-13 cm./dyne s33= 58.5×10-13 cm./dyne Hence the two linear compressibilities are, at 18°c., approximately: kperpendicular=-2.5×10-13 cm2/dyne; kparallel=50×10-13 cm2./dyne.
Natural Genetic Diversity as a Means to Uncover Stem Cell Regulatory Pathways (2009)

Natural genetic diversity is a largely untapped reservoir for use in the discovery of stem cell regulatory pathways. Here we explore the means by which phenotypic diversity in mice can lead to the discovery of novel genes affecting stem cell regulation. We use as an example the discovery that latexin is a regulator of the natural size of the hematopoietic stem cell population in mice. The fact that it is a negative regulator of stem cell numbers, and thus served as a brake on stem cell expansion, led us to consider the possibility that it acts as a tumor suppressor. Experimental evidence supporting this hypothesis is reviewed.
Performance of a Linear Ion Trap-Orbitrap Hybrid for Peptide Analysis (2005)

Proteomic analysis of digested complex protein mixtures has become a useful strategy to identify proteins involved in biological processes. We have evaluated the use of a new mass spectrometer that combines a linear ion trap and an Orbitrap to create a hybrid tandem mass spectrometer. A digested submandibular/sublingual saliva sample was used for the analysis. We find the instrument is capable of mass resolution in excess of 40,000 and mass measurement accuracies of less than 2 ppm for the analysis of complex peptide mixtures. Such high mass accuracy allowed the elimination of virtually any false positive peptide identifications, suggesting that peptides that do not match the specificity of the protease used in the digestion of the sample should not automatically be considered as false positives. Tandem mass spectra from the linear ion trap and from the Orbitrap have very similar ion abundance ratios. We conclude this instrument will be well suited for shotgun proteomic types of analyses.
Preparation and Characterization of Activated Carbon from Iraqi Khestawy Date Palm (2015)

This work includes a synthesis of three types of the activated carbon (AC) from three different positions from the same Iraqi Khestawy date palm. These three positions are the palm fronds (AC1), the date palm seeds (AC2), and the palm fiber (AC3). These three types of AC were synthesized by a physiochemical activation method using the same activator which was H 3 PO 4 . These materials were investigated using different techniques such as Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The adsorption activity of the synthesized AC samples was investigated by following the removal of both Bismarck brown G (BBG) and reactive yellow dye 145 (RY145). Both the kinetics of adsorption and the removal percentage of these dyes were investigated from the batch tests in this study. Different reaction parameters and conditions for adsorption processes were investigated. Also an investigation of both Langmuir and Freundlich adsorption isotherms was considered. The different physical properties of these materials were undertaken such as the point zero charges of the synthesized samples (PZCs), the percentage of humidity, and the adsorption capacity also being investigated. The activity of these materials in the removal of BBG from the aqueous solution was as follows: AC1 > AC2 > AC3.