gebhart/patrepeval huggingface dataset:
Stereospecific interaction of the quaternized opiate, N-methyllevorphanol, with opiate receptors (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific interaction of the quaternized opiate, N-methyllevorphanol, with opiate receptorsKent E. Opheim and Brian M. CoxCite this: J. Med. Chem. 1976, 19, 6, 857–858Publication Date (Print):June 1, 1976Publication History Published online1 May 2002Published inissue 1 June 1976https://pubs.acs.org/doi/10.1021/jm00228a029https://doi.org/10.1021/jm00228a029research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Deterministic doping to silicon and diamond materials for quantum processing (2016)

Nanoscale electronic devices will require the placement of dopants in a predetermined location, namely, a single atom control to explore novel functions for future nanoelectronics. Deterministic doping method, i.e. single-ion implantation, realizes ordered arrays of single-atoms in silicon, diamond and other materials, which might provide opportunities to single-dopant transport or single-photon source beneficial to quantum processing.
An invariant form for the prior probability in estimation problems (1946)

Abstract It is shown that a certain differential form depending on the values of the parameters in a law of chance is invariant for all transformations of the parameters when the law is differentiable with regard to all parameters. For laws containing a location and a scale parameter a form with a somewhat restricted type of invariance is found even when the law is not everywhere differentiable with regard to the parameters. This form has the properties required to give a general rule for stating the prior probability in a large class of estimation problems.
ASPD (Artificially Selected Proteins/Peptides Database): a database of proteins and peptides evolved in vitro (2002)

ASPD is a new curated database that incorporates data on full-length proteins, protein domains and peptides that were obtained through in vitro directed evolution processes (mainly by means of phage display). At present, the ASPD database contains data on 195 selection experiments, which were described in 112 original papers. For each experiment, the following information is given: (i) description of the target for binding, (ii) description of the protein or peptide which serves as the template for library construction and description of the native protein which binds the target, (iii) links to the major proteomic databases (SWISS-PROT, PDB, PROSITE and ENZYME), (iv) keywords referring to the biological significance of the experiment, (v) aligned sequences of proteins or peptides retrieved through in vitro evolution and relevant native or constructed sequences, (vi) the number of rounds of selection/amplification and (vii) the number of occurrences of clones with each sequence. The literature data include a full reference, a link to the MEDLINE database and the name of the corresponding author with his email address. ASPD has a user-friendly interface which allows for simple queries using the names of proteins and ligands, as well as keywords describing the biological role of the interaction studied, and also for queries based on authors' names. It is also possible to access the database by means of the SRS system, allowing complex queries. There is a BLAST search tool against the ASPD for looking directly for homologous sequences. Research tools of the ASPD allow the analysis of pairwise correlations in the sequences of proteins and peptides selected against one target. The URL for the ASPD database is http://www.sgi.sscc.ru/mgs/gnw/aspd/.
Role of Cellulose Fibrils and Exopolysaccharides of <i>Rhizobium leguminosarum</i> in Attachment to and Infection of <i>Vicia sativa</i> Root Hairs (2005)

Infection and subsequent nodulation of legume host plants by the root nodule symbiote Rhizobium leguminosarum usually require attachment of the bacteria to root-hair tips. Bacterial cellulose fibrils have been shown to be involved in this attachment process but appeared not to be essential for successful nodulation. Detailed analysis of Vicia sativa root-hair infection by wild-type Rhizobium leguminosarum RBL5523 and its cellulose fibril-deficient celE mutant showed that wild-type bacteria infected elongated growing root hairs, whereas cellulose-deficient bacteria infected young emerging root hairs. Exopolysaccharide-deficient strains that retained the ability to produce cellulose fibrils could also infect elongated root hairs but infection thread colonization was defective. Cellulose-mediated agglutination of these bacteria in the root-hair curl appeared to prevent entry into the induced infection thread. Infection experiments with V sativa roots and an extracellular polysaccharide (EPS)- and cellulose-deficient double mutant showed that cellulose-mediated agglutination of the EPS-deficient bacteria in the infection thread was now abolished and that infection thread colonization was partially restored. Interestingly, in this case, infection threads were initiated in root hairs that originated from the cortical cell layers of the root and not in epidermal root hairs. Apparently, surface polysaccharides of R. leguminosarum, such as cellulose fibrils, are determining factors for infection of different developmental stages of root hairs.
Planeten, Leben und Intelligenz (1986)

Als ich am 7. Tage des Januars dieses gegenwärtigen Jahres 1610 in der ersten Stunde der folgenden Nacht die Himmelskonstellationen durch ein Teleskop betrachtete, bot sich der Planet Jupiter meinen Blicken dar, und da ich für mich ein ganz hervorragendes Instrument gebaut hatte, bemerkte ich eine Erscheinung, die ich bisher wegen der mangelnden Vergrößerungskraft meines anderen Instrumentes noch nie hatte beobachten können, daß nämlich drei kleine wiewohl helle Sterne sich nahe dem Jupiter aufhielten; trotzdem ich meinte, sie gehörten zur großen Menge der Fixsterne, erregten sie dennoch auf eine besondere Weise meine Verwunderung, da sie genau in einer geraden Linie parallel zur Ekliptik sich angeordnet hatten und heller als die übrigen Sterne von gleicher Größe schienen. Ihre gegenseitigen Positionen und in Bezug auf Jupiter waren die Folgenden: Auf der Ostseite befanden sich zwei dieser Sterne und nur ein einziger im Westen. Der am weitesten im Osten stehende Stern und der westliche schienen mir aber ziemlich viel größer als der Dritte. Ich bekümmerte mich zunächst überhaupt nicht um ihren Abstand vom Jupiter, da ich, wie ich schon sagte, glaubte, sie seien Fixsterne. Aber als ich am 8. Januar, wohl durch ein gutes Geschick geleitet, wieder meinen Blick in das gleiche Himmelsgebiet wandte, fand ich einen sehr unterschiedlichen Zustand der Dinge vor, denn jetzt hielten sich drei kleine Sterne alle im Westen von Jupiter auf und zwar viel näher beieinander als in der vorhergegangenen Nacht, und sie waren durch gleiche Zwischenräume voneinander getrennt... Obwohl ich meine Gedanken überhaupt nicht auf die Nähe der Sterne voneinander gerichtet hatte, machte mich diese Überraschung doch stutzig, wie es denn sein könne, daß Jupiter nur nach einem Tag im Osten aller dieser erwähnten Fixsterne gefunden wurde, während er einen Tag zuvor doch westlich von zweien von ihnen gestanden hatte, und fürderhin begann ich zu argwöhnen, daß der Planet womöglich ganz abweichend von den Rechnungen der Astronomen durch seine eigene Bewegung an diesen Sternen hatte vorbeilaufen können. Ich erwartete also mit größter Ungeduld die folgende Nacht, aber meine Hoffnung wurde enttäuscht, denn der Himmel zeigte sich in jeder Richtung wolkenbedeckt... Aber dann erblickte ich am 11. Januar eine Anordnung in der folgenden Weise: Nur zwei Sterne im Osten von Jupiter, wobei der nähere dreimal weiter vom Jupiter entfernt war, als von dem am weitesten im Osten befindliche; und der am weitesten östlich sich aufhaltende Stern war fast zweimal so groß wie der erste, während doch in der vorangegangenen Nacht sie mir von gleicher Größe erschienen waren. Ich folgerte daraus und entschied mich ohne Zaudern zu der Annahme, daß sich dort am Himmel drei Gestirne befanden, die den Jupiter ebenso umkreisten, wie Merkur und Venus die Sonne; das wurde mir durch zahlreiche weitere Beobachtungen allmählich so klar wie das Tageslicht. Aus: Der Sternenbote des Galileo Galilei, Venedig, 1610
The Temperature Dependence of the Self-Diffusion Coefficients of Argon, Neon, Nitrogen, Oxygen, Carbon Dioxide, and Methane (1950)

The self-diffusion coefficients of A, Ne, ${\mathrm{N}}_{2}$, ${\mathrm{O}}_{2}$, C${\mathrm{O}}_{2}$, and C${\mathrm{H}}_{4}$ have been measured as functions of the temperature: A, Ne, ${\mathrm{N}}_{2}$, and ${\mathrm{O}}_{2}$ in the range --- 196\ifmmode^\circ\else\textdegree\fi{}C to 80\ifmmode^\circ\else\textdegree\fi{}C, ${\mathrm{CO}}_{2}$ in the range --- 78.5\ifmmode^\circ\else\textdegree\fi{}C to 80\ifmmode^\circ\else\textdegree\fi{}C, and C${\mathrm{H}}_{4}$ in the range --- 183\ifmmode^\circ\else\textdegree\fi{}C to 80\ifmmode^\circ\else\textdegree\fi{}C. The experimental figures have been compared with values calculated on the assumption that the molecular interaction potential is of the form$V(r)=4\ensuremath{\epsilon}[\ensuremath{-}{(\frac{{r}_{0}}{r})}^{6}+{(\frac{{r}_{0}}{r})}^{12}]$ With the exception of the lowest point for methane, all figures are in essential agreement with theory.
Metabolism of Δ<sup>1</sup>-Tetrahydrocannabinol by Rats Tolerant to Cannabis (1974)

Daily treatment of rats with phenobarbital, 75 mg/kg, for 5 days resulted in an induction of the metabolism of 14 C-Δ 1 -transterahydrocannabinol (THC) in vitro and in vivo. Although the K m and V max for THC metabolism by liver preparations in vitro were not altered, the rate of formation of highly polar THC metabolites was significantly increased and the final concentration of 7-hydroxy-Δ 1 -THC was decreased. Phenobarbital also significantly increased the rate of biliary excretion of THC and its metabolites and their disappearance from the blood and tissues.In one experiment, rats receiving a marihuana extract daily (providing THC, 5–10 mg/kg) failed to gain body weight during the first week of treatment, but then became tolerant to this effect. But neither the rate of THC metabolism in vitro nor the pattern of metabolites formed was influenced in the tolerant animals compared to controls. In another experiment, rats were shown to become tolerant on chronic treatment with marihuana extract, as indicated by a reduction in marihuana-induced enhancement of ethanol sleeping time. The biliary excretion, disappearance from the blood, and residual tissue levels of THC and its metabolites were not altered in the tolerant animals compared to pair-fed and ad libitum-fed controls. Therefore the mechanism of tolerance development to cannabis in the rat is more likely of CNS than of metabolic origin.
Ultrafast response times and enhanced optical nonlinearity in beryllium-doped low-temperature-grown GaAs (1998)

Summary form only given. We demonstrate that beryllium doping of low temperature-grown (LT) GaAs considerably shortens the initial decay time of the nonlinear absorption to values of about 100 fs. Be doping of LT GaAs improves the time response, the absorption modulation, and the nonsaturable losses.
Power‐aware optimization of CPU and frequency allocation based on fairness of QoS (2007)

Abstract In embedded real‐time systems, it is important to reduce energy consumption in order to achieve efficient energy utilization. Many investigations have focused on Quality of Service (QoS) control, which adapts the resource consumption of task execution by adapting the QoS of the tasks. In our past work, fairness of QoS has been focused on in the QoS adaptation control methods we have proposed. In this paper, a CPU clock cycle and frequency allocation problem, whose objectives are to minimize the energy consumption for task execution and to maximize the QoS while guaranteeing fairness of QoS, is formulated as a multiobjective optimization problem. We also propose to obtain a Pareto‐optimal solution of the problem by using the weighted‐sum optimization method. © 2007 Wiley Periodicals, Inc. Syst Comp Jpn, 38(12): 37–45, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/scj.20819
Electrodes and electrochemical cells (1993)

Well, here we are four chapters into this book and already at the heart of electrochemistry. In this chapter you will learn what happens when two electronic conductors (the electrodes) are brought together in a solution containing ions (the electrolyte). You already know a lot about the effect of a huge lump of metal on a bunch of ions, but now we are going to allow those ions or species in solution to do more than set up double layers or simply adsorb. The essence of electrochemistry is that many species react at conductors in solution, gaining or losing electrons. If this is allowed to happen, currents flow: electron currents in the wires connecting the electrodes, and ion currents in the electrolyte. Even if no current flows, the fact that all this chemistry is poised and about to happen manifests itself as a voltage that can be measured across the cell.
Effective Design of Novel Compact Fractal-Shaped Microstrip Coupled-Line Bandpass Filters for Suppression of the Second Harmonic (2009)

Novel compact fractal-shaped microstrip coupled-line bandpass filters employing Koch curves for suppression of the second harmonic are proposed, and their effective design procedure is provided. The proposed filters are implemented and measured, and the measurement results show the proposed filters achieved a maximum harmonic suppression of more than 60 dB, and a maximum circuit size reduction of 31%.
A 1.3-degree I/Q phase error, 7.1 &#x2013; 8.7-GHz LO generator with single-stage digital tuning polyphase filter (2010)

We have developed an LO generator having 1) a digitally I/Q imbalance tuning polyphase filter and 2) a PLL with a varactor-based VCO and an interleaved charge pump for wide frequency operation. A 90-nm CMOS implementation showed that the equivalent maximum phase error was below 1.3 degrees in 7.1 - 8.7-GHz frequency range.
Neural network communication receiver based on the nonlinear filtering (2003)

A neural-based network is applied to the data communication receiver to investigate the feasibility of the network over inter-symbol interference (ISI) and additive white Gaussian noise channel environments. With a three-layered perceptron with either backward error propagation or extended Kalman filter training algorithms, it can be shown that it closely approximates the theoretical optimum receiver as the number of network trainings increases. The simulations are made on the network operations, and error rate performance for several important parameters is given. The proposed data receiver is an alternative to the optimum Viterbi channel decoder once the problem on the network training is solved.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Sequence and analysis of genomic sequences upstream of mei-3. (1994)

he Neurospora crassa mei-3 mutation causes sensitivity to various DNA damaging agents (Newmeyer and Galeazzi 1977 Genetics 85:461-487). We have recently cloned and mapped a genomic fragment capable of transforming mei-3 spheroplasts to wild type (Cheng et al. 1993 Mut. Res. 294:223-234). These experiments predicted the putative coding sequence of mei-3 or at least the region encompassing the mei-3 mutation. It was determined by homology that Mei-3 belongs to the RecA-like group of proteins (Bishop et al. 1992 Cell 69:439-456) which are intimately involved in the recombination process and had been previously identified only in prokaryotes. Since the identification of RecA-like proteins in Saccharomyces (Shinohara et al. 1992 Cell 69:457-470) and in Neurospora, our hypothesis that this important group of proteins may be highly conserved in other eukaryotes has been substantiated with the cloning of several Rec-A like proteins from mouse, chicken, lily, and human (Shinohara et al. 1993 Nat. Genet. 4:239-243). Using these data there is evidence that additional homology, upstream of our putative start site, to these other proteins exists (an additional 67% over 39 amino acids between Mei-3 and mouse Rad51: Figure 1). However, this region of homology lacks a start site or obvious splice sites. This might suggest the presence of an unidentified upstream start sequence and another exon without obvious splice sequences. In an attempt to address this possibility, we sequenced both strands of the previously unpublished genomic sequence, from -2519 to -271 bp upstream of the putative 5' end of mei-3.
Hypoglycaemia following Partial Gastrectomy (1947)

During a routine follow-up of 45 consecutive patients on whom a partial gastrectomy had been performed for peptic ulcer we noted symptoms of dizziness, palpitation, sweat ing, epigastric discomfort, and a feeling of weakness progressing in several instances to complete loss of con sciousness-in 17. These symptoms, coming on in from one-half to one and a half hours after food, were rapidly relieved by taking sugar or other easily assimilated carbo hydrate. In this series they were far the commonest com plication of partial gastrectomy, being greatly in excess of stomal ulcer and anaemia, which receive such a prominent place in the literature on the subject. Five of the patients were in consequence so severely disabled that they had become totally unfit for employment. Many of them, however, did not associate their symptoms with their oper ation, as their sensations seemed to be quite unconnected with the previous dyspepsia. In a follow-up of patients who have had a partial gastrectomy this syndrome may therefore be overlooked unless leading questions are asked. Such symptoms have been noted previously, chiefly in the German literature by Lapp and Dibold (1933), Beckermann (1933), Koranyi (1936), and Wohrle (1936). Evensen (1942) found that in 34 out of 95 cases of partial gastrectomy the blood sugar fell on occasion to less than 65 mg. per 100 ml. Adlersberg and Hammerschlag (1947), investigating the post-gastrectomy syndrome, demon strated a hypoglycaemic type of blood-sugar curve in all their 14 cases. There is a curious absence of reference in British literature to post-gastrectomy hypoglycaemia; the dumping syndrome, however, is often mentioned, but is usually attributed to vagotonia, the result of jejunal dis tension from precipitate gastric evacuation.
An Efficient Algorithm of Isoline Generating and Color Filling Based on Square Grid (2011)

The research proposed in this paper introduces an efficient algorithm whose objective is to generate isoline and fill color between isolines, and it is based on square grid. In addition to adaptive curve smoothing, the novelty of our approach is building of topological trees, which are used to describe accurately the clipping operation sequence among different connected regions. Finally, the algorithm is fully implemented by assigning appropriate colors to clipped multipolygons. Owing to an efficient and stable performance, the algorithm has been integrated into GIS (Geographical Information system) core components for several application systems in practice.
Light emission from a polymer transistor (2004)

We report on light emission from a polymeric transistor that utilizes interdigitated source and drain electrodes with channel length of 5 μm in a bottom gate configuration based on a Si/SiO2 substrate. The polymer investigated is poly[9,9-di(ethylhexyl)fluorene] deposited by spin coating from chloroform solution to achieve an active layer thickness of 40 nm. Light emission occurs above drain source voltages of −60 V and the light intensity can be controlled by the gate voltage. Emission occurs close to the drain electrode as determined by optical microscopy. The transistor operates in hole accumulation mode without saturation of the output characteristics.
Advanced formulation design of venlafaxine hydrochloride coated and triple-layer tablets containing hypromellose (2009)

The purpose of this research work was to develop venlafaxine hydrochloride-coated and layered matrix tablets using hypromellose adopting wet granulation technique. The granules and the tablets were characterized. The monolithic tablets were coated with different ratios of ethyl cellulose and hypromellose. The in vitro dissolution study was performed in distilled water. In the layered tablets, the middle layer containing drug was covered with barrier layers containing high viscosity grade hypromellose. Simplex lattice design was used for formulating the layered tablets. The dissolution study of the optimized batches and a reference product was carried out in 0.1 N HCl, phosphate buffer and hydroalcoholic solution. Burst drug release was exhibited by the uncoated tablets, probably due to high aqueous solubility of venlafaxine HCl. The coated tablets showed sustained drug release without burst effect. The drug release was best explained by Weibull model. A unified Weibull equation was evolved to express drug release from the coated tablets. The layered tablets also exhibited sustained release without burst effect due to effective area reduction. The optimized batches showed identical drug release in 0.1 N HCl, phosphate buffer and 10% v/v aqueous alcohol. Layered tablets may well be adopted by the industry due to the possibility of achieving a high production rate.
Thermal tuning capabilities of semiconductor metasurface resonators (2018)

Abstract Metasurfaces exploit optical phase, amplitude, and polarization engineering at subwavelength dimensions to achieve unprecedented control of light. The realization of all dielectric metasurfaces has led to low‐loss flat optical elements with functionalities that cannot be achieved with metal elements. However, to reach their ultimate potential, metasurfaces must move beyond static operation and incorporate active tunability and reconfigurable functions. The central challenge is achieving large tunability in subwavelength resonator elements, which requires large optical effects in response to external stimuli. Here we study the thermal tunability of high‐index silicon and germanium semiconductor resonators over a large temperature range. We demonstrate thermal tuning of Mie resonances due to the normal positive thermo‐optic effect (dn/dT>0) over a wide infrared range. We show that at higher temperatures and longer wavelengths, the sign of the thermo‐optic coefficient is reversed, culminating in a negative induced index due to thermal excitation of free carriers. We also demonstrate the tuning of high‐order Mie resonances by several linewidths with a temperature swing of ΔT<100 K. Finally, we exploit the large near‐infrared thermo‐optic coefficient in Si metasurfaces to realize optical switching and tunable metafilters.