gebhart/patrepeval huggingface dataset:
Vasopressin contributes to hyperfiltration, albuminuria, and renal hypertrophy in diabetes mellitus: Study in vasopressin-deficient Brattleboro rats (1999)

Diabetic nephropathy represents a major complication of diabetes mellitus (DM), and the origin of this complication is poorly understood. Vasopressin (VP), which is elevated in type I and type II DM, has been shown to increase glomerular filtration rate in normal rats and to contribute to progression of chronic renal failure in 5/6 nephrectomized rats. The present study was thus designed to evaluate whether VP contributes to the renal disorders of DM. Renal function was compared in Brattleboro rats with diabetes insipidus (DI) lacking VP and in normal Long-Evans (LE) rats, with or without streptozotocin-induced DM. Blood and urine were collected after 2 and 4 weeks of DM, and creatinine clearance, urinary glucose and albumin excretion, and kidney weight were measured. Plasma glucose increased 3-fold in DM rats of both strains, but glucose excretion was approximately 40% lower in DI-DM than in LE-DM, suggesting less intense metabolic disorders. Creatinine clearance increased significantly in LE-DM (P < 0.01) but failed to increase in DI-DM. Urinary albumin excretion more than doubled in LE-DM but rose by only 34% in DI-DM rats (P < 0.05). Kidney hypertrophy was also less intense in DI-DM than in LE-DM (P < 0.001). These results suggest that VP plays a critical role in diabetic hyperfiltration and albuminuria induced by DM. This hormone thus seems to be an additional risk factor for diabetic nephropathy and, thus, a potential target for prevention and/or therapeutic intervention.
<i>In Vitro</i>Transactivation Potencies of Black-Footed Albatross (<i>Phoebastria nigripes</i>) AHR1 and AHR2 by Dioxins To Predict CYP1A Expression in the Wild Population (2011)

Our previous studies have detected high levels of dioxins and related compounds (DRCs) including polychlorinated dibenzo-p-dioxins (PCDDs), furans (PCDFs), and coplanar PCBs (Co-PCBs) in the black-footed albatross (BFA), Phoebastria nigripes, from the North Pacific region. We have also cloned two aryl hydrocarbon receptors, AHR1 and AHR2, of the BFA. To evaluate the sensitivity to DRCs in the BFA and to assess the status of cytochrome P450 1A (CYP1A) induction in the wild population, this study investigated the mRNA expression levels of BFA AHR1 and AHR2 and also the transactivation potencies of each AHR by 15 selected DRC congeners. Quantitative real-time PCR of BFA AHR mRNAs showed that hepatic AHR1 is more highly expressed than AHR2. Transactivation by graded concentrations of individual DRCs was measured in COS-7 cells, where BFA AHR1 or AHR2 was transiently transfected. For congeners that exhibited AHR-mediated dose-dependent activities, 50% effective concentration (EC(50)) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) relative potencies (REPs) were estimated. Based on the estimates of the REPs, TCDD induction equivalency factors (IEFs) were determined. For BFA AHR1, PeCDF was equipotent to TCDD, but other congeners exhibited lower IEFs. For BFA AHR2, PCDD/F congeners except OCDD/F showed IEFs ≥ 1.0. Using BFA AHR1- or AHR2-IEFs and hepatic concentrations of DRCs in North Pacific BFAs, TCDD induction equivalents (IEQs) were calculated. We further constructed nonlinear regression models on the relationships between BFA AHR1- or AHR2-IEF derived total IEQ or WHO-TEF derived total TEQ and ethoxyresorufin-O-deethylase activity (EROD) in the liver of wild BFAs. The results indicated that the relationships of BFA AHR1- and AHR2-based IEQs and EROD were predictable from BFA AHR1- and AHR2-mediated transactivation by TCDD, respectively. Collectively, these results suggest that the in vitro assay incorporating the AHR of species of concern would be a useful tool to predict the sensitivity to DRCs in the species and CYP1A induction in the wild population.
Carbon mitigation with biomass: An engineering, economic and policy assessment of opportunities and implications (2007)

Forty-six women affected by late-onset or persistent acne were studied in order to investigate the frequency of hormonal abnormalities and polycystic ovaries. Hirsutism, perioral distribution of acne lesions and irregular menses were recorded. Hormonal measurements and ovarian echographies were performed. Twenty-four patients were affected with polycystic ovaries, detected by ultrasound scanning. Among the acne patients, the women with ovarian abnormalities had higher values of androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate and luteinizing hormone (LH), and a higher LHT/follicle-stimulating hormone ratio than those with acne and without ovarian abnormalities. This study indicates the prevalence of polycystic ovaries in women with late-onset or persistent acne. Moreover, hormonal abnormalities indicate a subgroup of acne patients defined by the presence of ovarian disorders.
Silk Fibroin as a Biomaterial Substrate for Corneal Epithelial Cell Sheet Generation (2012)

Purpose.: To evaluate a silk fibroin (SF) biomaterial as a substrate for corneal epithelial cell proliferation, differentiation, and stratification in vitro compared with denuded human amniotic membrane (AM). Methods.: Primary human and rabbit corneal epithelial cells and immortalized human corneal limbal epithelial cells were cultured on the SF and denuded AM, respectively. The biological cell behavior, including the morphology, proliferation, differentiation, and stratification, on the two substrates was compared and analyzed. Results.: Corneal epithelial cells can adhere and proliferate on the SF and denuded AM with a cobblestone appearance, abundant microvilli on the surface, and wide connection with the adjacent cells. MTT assay showed that cell proliferation on denuded AM was statistically higher than that on SF at 24 and 72 hours after plating (P = 0.001 and 0.0005, respectively). Expression of ΔNp63a and keratin 3/12 was detected in primary cell cultures on the two substrates with no statistical difference. When cultured at the air-liquid interface for 7 days, cells on SF could form a comparable stratified graft with a 2- to 3-cell layering, which compared similarly to AM cultures. Conclusions.: SF, a novel biomaterial, could support corneal epithelial cells to proliferate, differentiate, and stratify, retaining the normal characteristic epithelium phenotype. Compared with AM, its unique features, including the transparency, ease of handling, and transfer, and inherent freedom from disease transmission, make it a promising substrate for corneal wound repair and tissue-engineering purposes.
Robust nonlinear state estimation for a class of infinite-dimensional systems using reduced-order models (2019)

A methodology for designing robust, low-order observers for a class of spectral infinite-dimensional nonlinear systems is presented. This approach uses the low-dimensional subspace explicitly in the observer design. Then, robustness to bounded model uncertainties is incorporated using the Lyapunov reconstruction method from robust control theory. Furthermore, the proposed design includes a data-driven learning algorithm that auto-tunes the observer gains to optimise the performance of the state estimation. A numerical study using a model from fluid dynamics -Burgers equation- demonstrates the effectiveness of the proposed observer.
Detection of free radicals from low-temperature ozone-olefin reactions by ESR spin trapping: evidence that the radical precursor is a trioxide (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetection of free radicals from low-temperature ozone-olefin reactions by ESR spin trapping: evidence that the radical precursor is a trioxideWilliam A. Pryor, Donald G. Prier, and Daniel F. ChurchCite this: J. Am. Chem. Soc. 1983, 105, 9, 2883–2888Publication Date (Print):May 1, 1983Publication History Published online1 May 2002Published inissue 1 May 1983https://pubs.acs.org/doi/10.1021/ja00347a059https://doi.org/10.1021/ja00347a059research-articleACS PublicationsRequest reuse permissionsArticle Views189Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ceramic Membranes Photocatalytically Functionalized on the Permeate Side and Their Application to Water Treatment (2019)

This work deals with direct coupling of membrane separation and photocatalytic degradation by using photocatalytic ceramic membranes. An unusual configuration is considered here, with the irradiation applied on the permeate side of the membrane in order to mineralize small organic molecules not retained by the membrane. Different types of such membranes are presented. Their functional performance is quantified thanks to a simple experimental method enabling the estimation of the specific degradation rate <i>δ</i>, i.e., the quantity of destroyed organic molecules per unit of time and of membrane surface area. The relevance of <i>δ</i> for the design and scale-up of purification units is then illustrated. Finally, current technological challenges and potential solutions concerning the industrial implementation of such photocatalytic membranes are discussed.
Integration and Electrical Evaluation of Epitaxially Grown Si and SiGe Channels for Vertical NAND Memory Applications (2015)

Epitaxially grown Si and Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.6</sub> Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.4</sub> are integrated as replacement of poly-Si channel in vertical cylindrical transistors for vertical NAND memory application, in order to investigate the impact of the grain boundaries on current conduction. Epi-Si outperforms both poly-Si and Epi-SiGe channels, resulting in the best conduction, with large improvement on both sub threshold swing and transconductance (g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> ). The experimentally observed g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> bimodal distribution for epi Si is corroborated and explained through a resistive network model: lower g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> conduction occurs when current needs to cross a high resistance boundary, whereas higher g <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> is obtained when this boundary is not present.
Using digital micromirror devices for focusing light through turbid media (2014)

The holy grail of biomedical optical imaging is to perform microscopy deep inside living tissue. Unfortunately, biological tissue scatters light, which prevents the formation of a sharp focus. However, recently it was shown that wavefront shaping can be used to focus light through and inside turbid materials. So far, most experiments used liquid crystal devices, which are too slow to match the dynamics of perfused tissue. Since DMD technology is approximately 1000 times faster, it may bring wavefront shaping to in-vivo applications. We will compare analytically the performance of different methods for focusing light through scattering media with an intensity-only light modulator.
Swallowing function in patients with esophageal cancer treated with concurrent radiation and chemotherapy (1993)

High-dose concurrent radiation and chemotherapy provides rapid improvement in dysphagia, and this improvement results in normal or near-normal swallowing function of long duration.
Control of acyl-CoA carboxylase activity in mycobacteria (1992)

Acyl-CoA carboxylase activity in four pathogenic mycobacteria and Mycobacterium smegmatis was shown with both acetyl-CoA and propionyl-CoA substrates. Only very low activity was detected in mycobacteria grown in host tissues or on egg-based media rich in lecithin and avidin. This appeared to be a result of severe depression of activity, as strains which could be grown both in host tissue and egg-based media, and in the relatively simple Dubos or Sauton's media showed 8 to 120-fold higher activity in the simpler media.
Myosin V associates with melanosomes in mouse melanocytes: evidence that myosin V is an organelle motor (1997)

Mice with mutations at the dilute locus exhibit a 'washed out' or 'diluted' coat color. The pigments that are responsible for the coloration of mammalian hair are produced by melanocytes within a specialized organelle, the melanosome. Each melanocyte is responsible for delivering melanosomes via its extensive dendritic arbor to numerous keratinocytes, which go on to form the pigmented hair shaft. In this study, we show by light immunofluorescence microscopy and immunoelectron microscopy that the myosin V isoform encoded by the dilute locus associates with melanosomes. This association, which was seen in all mouse melanocyte cell lines examined and with two independent myosin V antibodies, was evident not only within completely melanized cells, but also within cells undergoing the process of melanosome biogenesis, where coordinate changes in the distributions of a melanosome marker and myosin V were seen. To determine where myosin V, a known actin-based motor, might play a role in melanosome transport, we also examined the cellular distribution of F-actin. The only region where myosin V and F-actin were both concentrated was in dendrites and dendritic tips, which represent the sole destination for melanosomes and where they accumulate in cultured melanocytes. These results support the idea that myosin V serves as the motor for the outward movement of melanosomes within dendritic extensions, and, together with the available information regarding the phenotype of mutant melanocytes in vitro, argue that coat color dilution is caused by the absense of this myosin V-dependent melanosome transport system.
Not So Revisionary: The Regressive Treatment of Gender in Alan Moore's Watchmen (2016)

While Alan Moore’s comic book Watchmen is often hailed as a revisionary text for introducing flawed superheroes and political anxiety to the genre, it is also remarkably regressive in its treatment of gender. Some critics do argue that women are given a newfound voice in Watchmen, but this interpretation neglects to examine character Laurie Jupiter adequately, or the ways in which other female characters' appearance and dialogue are limited and/or based on their sexuality and relationships with male characters. Watchmen's main female characters, mother and daughter Sally and Laurie Jupiter, lack autonomy and their identities are completely intertwined with and dependent on the male superheros that the two women interact with. This effect culminates with Earth's fate being dependent on Laurie’s relationship with fellow hero Jon - a fate that is determined through a conversation in which Laurie has no say. Written only as submissive, and depicted only as highly sexualized, Watchmen's female characters thus embody misogynistic, outdated ideas about women, even for the 1980s.
Partially nanowire-structured TiO2 electrode for dye-sensitized solar cells (2006)

Abstract Partially nanowire-structured TiO2 was prepared by a hydrothermal processing followed by calcination in air. The hydrogen titanate powder as-synthesized was calcined at 300 °C for 4 h to obtain the partially nanowire-structured TiO2. A dye-sensitized solar cell (DSC) with a film thickness of 5.6 μm, fabricated using the partially nanowire-structured TiO2 showed better performance than using a fully nanowire-structured TiO2 or a conventional equi-axed TiO2 nanopowder. The short-circuit current density (JSC), the open-circuit voltage (VOC), the fill factor (FF) and the overall efficiency (η) are 11.9 mA/cm2, 0.754 V, 0.673 and 6.01 %, respectively. The effects of one-dimensional nanostructure and electron expressway concept are discussed.
Growth inhibitory properties of endothelin-1 in human hepatic myofibroblastic Ito cells. An endothelin B receptor-mediated pathway. (1995)

Ito cells play a pivotal role in the development of liver fibrosis associated with chronic liver diseases. During this process, Ito cells acquire myofibroblastic features, proliferate, and synthesize fibrosis components. Considering the reported mitogenic properties of endothelin-1 (ET-1), we investigated its effects on the proliferation of human Ito cells in their myofibroblastic phenotype. Both ET receptor A (ETA: 20%) and ET receptor B (ETB: 80%) binding sites were identified, using a selective ETA antagonist, BQ 123, and a selective ETB agonist, sarafotoxin S6C (SRTX-C). ET-1 did not stimulate proliferation of myofibroblastic Ito cells. In contrast, ET-1 inhibited by 60% DNA synthesis and proliferation of cells stimulated with either human serum or platelet-derived growth factor -BB (PDGF-BB). PD 142893, a nonselective ETA/ETB antagonist totally blunted this effect. SRTX-C was as potent as ET-1, while BQ 123 did not affect ET-1-induced growth inhibition. Analysis of the intermediate steps leading to growth-inhibition by ET-1 revealed that activation of mitogen-activated protein kinase by serum or PDGF-BB was decreased by 50% in the presence of SRTX-C. In serum-stimulated cells, SRTX-C reduced c-jun mRNA expression by 50% whereas c-fos or krox 24 mRNA expression were not affected. We conclude that ET-1 binding to ETB receptors causes a potent growth inhibition of human myofibroblastic Ito cells, which suggests that this peptide could play a key role in the negative control of liver fibrogenesis. Our results also point out that, in addition to its well known promitogenic effects, ET-1 may also exert negative control of growth on specific cells.
A context management architecture for large-scale smart environments (2010)

Context-aware architecture collects various context data from heterogeneous sensors and provides an intelligent service by exploiting the collected data. In this article we explain the generalized context-aware software architecture for heterogeneous smart environments. The proposed architecture integrates large-scale contexts from multiple heterogeneous sensors, and makes a semantic decision by fusing and reasoning about the collected contexts. Moreover, we discuss a designed architecture that manages communities between large numbers of heterogeneous information entities and enhances intelligence abilities.
Entwicklung der Spitzengasabgabe und Möglichkeiten zur Deckung der Spitzenbelastungen durch herkömmliche Erzeugungsmaßnahmen (1955)

In den letzten beiden Jahrzehnten ist das Gas in steigendem Maße zur Beheizung sowohl von Wohnungen als auch von Gewerbe- und Industriebetrieben herangezogen worden. Daher ist in den meisten Versorgungsgebieten der Gasverbrauch im Winter wesentlich höher als im Sommerhalbjahr. In einzelnen Versorgungsgebieten liegt die Winter-Spitzenabgabe bereits mehr als doppelt so hoch als die durchschnittliche Sommerabgabe. Es hat den Anschein, als ob die weitere Zukunft ein noch stärkeres Anwachsen der Winterabgabe und damit ein stärkeres Ansteigen der Spitzen bringen wird. Die Gasheizung bringt also eine temperaturabhängige scharfe Spitzenbelastung mit sich. Die Bewältigung dieser Spitzenbelastung kann nur durch möglichst elastische Betriebsweise erfolgen. Neben der Gasheizung kommt aber immer mehr auch die Ölheizung zum Zuge, wenngleich wir hier auch erst am Anfang einer Entwicklung stehen, die sich im benachbarten Ausland bereits in erheblichem Maße vollzogen hat. Die Gas- und Ölheizung gemeinsam erschweren den Koksabsatz. Dadurch wird die Wirtschaftlichkeit der Gasversorgung in ihrer bisherigen Verfahrensweise an einer ganz empfindlichen Stelle getroffen.
Experimental Study on OSNR Requirements for Spectrum-Flexible Optical Networks [Invited] (2012)

The flexibility and elasticity of the spectrum is an important topic today. As the capacity of deployed fiber-optic systems is becoming scarce, it is vital to shift towards solutions ensuring higher spectral efficiency. Working in this direction, we report an extensive experimental study on adaptive allocation of superchannels in spectrum-flexible heterogeneous optical network. In total, three superchannels were transmitted. Two 5-subcarrier 14-GHz-spaced, 14 Gbaud, polarization-division-multiplexed (PDM) quadrature-phase-shift-keyed (QPSK) superchannels were separated by a spectral gap, the band of interest (BOI). The bandwidth of the BOI was varied. The BOI was subsequently filled with another superchannel, constituted by a different number of either 14 Gbaud PDM-QPSK or PDM-16-ary quadrature amplitude modulation (16-QAM) subcarriers. The optical signal-to-noise ratio (OSNR) for transmission of the subcarriers inserted into the BOI, depending on the modulation format, subcarrier count and spacing to the neighboring superchannels, was extracted through experimental implementation of different scenarios. The obtained values were interpolated to yield the required OSNR necessary to maintain a 1×10−3 bit error rate of the central BOI subcarrier. The results provide a rule of thumb that can be exploited in resource allocation mechanisms of future spectrum-flexible optical networks.
Multiframe selective information fusion from robust error estimation theory (2005)

A dynamic procedure for selective information fusion from multiple image frames is derived from robust error estimation theory. The fusion rate is driven by the anisotropic gain function, defined to be the difference between the Gaussian smoothed-edge maps of a given input frame and of an evolving synthetic output frame. The gain function achieves both selection and rapid fusion of relatively sharper features from each input frame compared to the synthetic frame. Effective applications are demonstrated for image sharpening in imaging through atmospheric turbulence, for multispectral fusion of the RGB spectral components of a scene, for removal of blurred visual obstructions from in front of a distant focused scene, and for high-resolution two-dimensional display of three-dimensional objects in microscopy.
Fast Feature Extraction with CNNs with Pooling Layers (2018)

In recent years, many publications showed that convolutional neural network based features can have a superior performance to engineered features. However, not much effort was taken so far to extract local features efficiently for a whole image. In this paper, we present an approach to compute patch-based local feature descriptors efficiently in presence of pooling and striding layers for whole images at once. Our approach is generic and can be applied to nearly all existing network architectures. This includes networks for all local feature extraction tasks like camera calibration, Patchmatching, optical flow estimation and stereo matching. In addition, our approach can be applied to other patch-based approaches like sliding window object detection and recognition. We complete our paper with a speed benchmark of popular CNN based feature extraction approaches applied on a whole image, with and without our speedup, and example code (for Torch) that shows how an arbitrary CNN architecture can be easily converted by our approach.