gebhart/patrepeval huggingface dataset:
Task model of lower body motion for a biped humanoid robot to imitate human dances (2005)

The goal of this study is developing a biped humanoid robot that can observe a human dance performance and imitate it. To achieve this goal, we propose a task model of lower body motion, which consists of task primitives (what to do) and skill parameters (how to do it). Based on this model, a sequence of task primitives and their skill parameters are detected from human motion, and robot motion is regenerated from the detected result under constraints of a robot. This model can generate human-like lower body motion including various waist motions as well as various stepping motions of the legs. Generated motions can be performed stably on an actual robot supported by its own legs. We used improved robot hardware HRP-2, which has superior features in body weight, actuators, and DOF of the waist. By using the proposed method and HRP-2, we have realized a dance performance of Japanese folk dance by the robot, which is synchronized with a performance of a human grand master on the same stage.
Electric stress grading of composite bushings using high dielectric constant silicone compositions (2005)

The paper presents the results of a study on the use of high dielectric constant silicone housing compositions on composite bushings to shape the electric stress in the vicinity of the mounting flange, thereby eliminating the need for separate grading rings or capacitor foils. The materials studied are various mixtures of barium titanate and aluminum powder in a two-part RTV silicone yielding a dielectric constant of 15, and sufficiently low in concentration as not to affect the molding properties of the silicone.
Pharmacologic Control of Feeding (1977)

After a traumatic childhood in Europe during the Second World War, I found that scientific research in Israel was a pleasure beyond my expectations. Over the last 65 year, I have worked on the chemistry and pharmacology of natural products. During the ...Read More
Analysis of IgE Antibodies from a Patient with Atopic Dermatitis: Biased V Gene Usage and Evidence for Polyreactive IgE Heavy Chain Complementarity-Determining Region 3 (2002)

To better understand V gene usage, specificity, and clonal origins of IgE Abs in allergic reactions, we have constructed a combinatorial Ab library from the mRNA of an adult patient with atopic dermatitis. Sequence analysis of random clones revealed that 33% of clones used the IGHV6-1 H chain V gene segment, the only member of the V(H)6 gene family. IGHV6-1 is rarely used in the expressed adult repertoire; however, it is associated with fetal derived Abs. Features of the V(H)6 rearrangements included short complementarity-determining region 3, frequent use of IGHD7-27 D gene, and little nucleotide addition at the D-J junction. There was also a low level of mutation compared with V(H)1, V(H)3, and V(H)4 rearrangements. The library was expressed as phage-Fab fusions, and specific phage selected by panning on the egg allergen ovomucoid. Upon expression as soluble IgE Fabs, 12 clones demonstrated binding to ovomucoid, skim milk, and BSA by ELISA. Nucleotide sequencing demonstrated that the IGHV6-1 V gene segment encoded each of the 12 multiply reactive IgE Fabs. A cyclic peptide was designed from the complementarity-determining region 3 of several of these clones. The cyclic peptide bound both self and nonself Ags, including ovomucoid, human IgG, tetanus toxoid, and human and bovine von Willebrand factor. These results suggest that some IgE Abs may bind more than one Ag, which would have important implications for understanding the multiple sensitivities seen in conditions such as atopic dermatitis.
myo-Inositol Oxygenase: A Novel Kidney-Specific Biomarker of Acute Kidney Injury? (2014)

Acute kidney injury (AKI)2 is an increasingly recognized syndrome associated with short-term and long-term morbidity and mortality. Recent studies have demonstrated that even mild AKI portends an increased risk of chronic kidney disease (1). There is thus great impetus to develop novel therapies for treatment of AKI. Several agents are currently being tested in phase I/II clinical trials (2). Despite these ongoing efforts, no effective therapeutic agents have yet emerged on the clinical scene. Some of the reasons for the lack of beneficial therapies in AKI include incomplete understanding of the pathogenesis of this disorder and the absence of early and reliable markers of AKI, which may enable treatment before irreversible injury ensues. The importance given to the development of novel biomarkers is high, as evidenced by the proclamation of the American Society of Nephrology to designate this research endeavor a top priority (3).

Biomarkers of AKI have represented an area of active research in the last decade. These biomarkers should identify those at risk, enable a timely diagnosis of AKI (i.e., before the alterations in traditional markers), stratify patients on the basis of prognosis, and improve understanding of the nephron segment(s) affected (4). Markers of renal dysfunction in current use lack both specificity and sensitivity. Serum creatinine is the most widely employed marker of AKI. However, it is a late marker, highly nonspecific to the site or type of injury. It predicts glomerular filtration rate (GFR) only in the steady state and varies with muscle mass and diet. Another biomarker used in the diagnosis of AKI is urine output. Urine output is unreliable except in monitored settings such as intensive care, and it can be altered by administration of fluids and diuretics. Despite their shortcomings, serum creatinine and urine output are the diagnostic biomarkers of AKI included …
In silico fragmentation for computer assisted identification of metabolite mass spectra (2010)

We presented a method that is able to identify small molecules from tandem MS measurements, even without spectral reference data or a large set of fragmentation rules. With today's massive general purpose compound libraries we obtain dozens of very similar candidates, which still allows a confident estimate of the correct compound class. Our tool MetFrag improves the identification of unknown substances from tandem MS spectra and delivers better results than comparable commercial software. MetFrag is available through a web application, web services and as java library. The web frontend allows the end-user to analyse single spectra and browse the results, whereas the web service and console application are aimed to perform batch searches and evaluation.
Deletion of the UT receptor gene results in the selective loss of urotensin‐II contractile activity in aortae isolated from UT receptor knockout mice (2003)

1 Urotensin-II (U-II) is among the most potent mammalian vasoconstrictors identified and may play a role in the aetiology of essential hypertension. Currently, only one mouse U-II receptor (UT) gene has been cloned. It is postulated that this protein is solely responsible for mediating U-II-induced vasoconstriction. 2 This hypothesis has been investigated in the present study, which assessed basal haemodynamics and vascular reactivity to hU-II in wild-type (UT((+/+))) and UT receptor knockout (UT((-/-))) mice. 3 Basal left ventricular end-diastolic and end-systolic volumes/pressures, stroke volumes, mean arterial blood pressures, heart rates, cardiac outputs and ejection fractions in UT((+/+)) mice and in UT((-/-)) mice were similar. 4 Relative to UT((+/+)) mouse isolated thoracic aorta, where hU-II was a potent spasmogen (pEC(50)=8.26+/-0.08) that evoked relatively little vasoconstriction (17+/-2% 60 mM KCl), vessels isolated from UT((-/-)) mice did not respond to hU-II. However, in contrast, the superior mesenteric artery isolated from both the genotypes did not contract in the presence of hU-II. Reactivity to unrelated vasoconstrictors (phenylephrine, endothelin-1, KCl) and endothelium-dependent/independent vasodilator agents (carbachol, sodium nitroprusside) was similar in the aorta and superior mesenteric arteries isolated from both the genotypes. 5 The present study is the first to directly link hU-II-induced vasoconstriction with the UT receptor. Deletion of the UT receptor gene results in loss of hU-II contractile action with no 'nonspecific' alterations in vascular reactivity. However, as might be predicted based on the limited contractile efficacy recorded in vitro, the contribution that hU-II and its receptor make to basal systemic haemodynamics appears to be negligible in this species.
Purification of flue gas by ionic liquids: Carbon monoxide capture in [bmim][Tf<sub>2</sub>N] (2013)

Knowledge of the solubility of carbon monoxide in ionic liquids is important for investigating the potential use of ionic liquids in reactions and gas separations. There is very limited information available on the capacity of ionic liquids to capture CO. The solubility of CO in 1‐butyl‐3‐methylimidazolium bis(trifluoromethylsulfonyl)imide was investigated experimentally up to temperatures and pressures of 460 K and 10 MPa, respectively. The solubility was shown to be only slightly temperature‐dependent, and the P–T diagram for a constant composition mixture is concave‐downward with a peak in pressure. By comparing the single‐gas solubility results of CO with various other gases in the same ionic liquid, it seems that ionic liquids can potentially be used as gas‐separating media. However, although the single‐gas solubilities vary considerably among some gases, further studies on mixed (multicomponent) gases should be carried out as the presence of other components can influence the solubility of each gas component. © 2013 American Institute of Chemical Engineers AIChE J , 59: 3886–3891, 2013
The effects of the incorporation of chlorhexidine acetate on some physical properties of polymerized and plasticized acrylics (1981)

The effects on the water uptake and weight loss of the incorporation of chlorhexidine acetate in heat cured acrylic and an acrylic gel soft liner was determined. Hardness and transverse bend measurement were similarly made for admixtures to heat and cold cured acrylics. Following soaking in water for 87 days the heat cured test specimens demonstrated an initial weight gain followed by a progressive loss, the soft liner test specimens however all showed weight gains. Drying back specimens to constant weight revealed significantly greater weight losses in test compared to control specimens for both the cured acrylic and gel liner. However these weight losses were less than the chlorhexidine content for 5 and 10% admixtures. Hardness and moduli of elasticity measurements were significantly reduced for heat and cold cured acrylics containing chlorhexidine. The property changes observed in the materials would be consistent with the pattern of incorporation of chlorhexidine into the matrix. However, these do not negate the carriage of medicaments in these materials for prolonged delivery within the oral cavity, if employed as rebase or reline materials in existing prostheses.
Neuromorphic System Based on CMOS Inverters and Si-Based Synaptic Device (2016)

We developed an analog neuron circuit that can work with Si-based synaptic devices. N-channel and p-channel synaptic devices connected to current mirrors constitute the synaptic connection and integration parts to implement the excitation and inhibition mechanisms of biological neurons. The normal inverter controlling delay time and the modified inverter making negative pulse constitute the action-potential generation part to generate output action-potential. Connecting output potential to the synaptic device, we implement the spike-timing-dependent-plasticity (STDP) mechanism, adjusting the conductance of synapse. As we have constituted the analog neuron circuit using 4-terminal synaptic device without additional switch and logic operation, we can emulate the operation of the neuron with minimum number of devices and power dissipation.
Intestinal parasitic infections and eosinophilia in an human immunedeficiency virus positive population in Honduras (2004)

The occurrence of intestinal parasites, their regional distribution and their relations to eosinophilia were studied in 133 human immunodeficiency virus (HIV) positive individuals from Honduras. After signing an informed consent, participants answered a socio-demographic and risk factor questionnaire, a complete physical examination, medical history, and a series of laboratory tests. All participants were HIV positive but not acquired immunodeficiency syndrome positive. Of them, 67% were co-infected with pathogen and non pathogen parasites. Overall occurrence of nematodes was: 44.3% for Trichuris trichiura, 24% for Ascaris lumbricoides, 12% for Hookworm and 7.5% for Strongyloides stercoralis. No cases of Giardia lamblia, acute amebiasis or cryptosporidiasis were diagnosed. Mean eosinophil percents for participants were consistently and significantly higher in infected than in non infected individuals: 22% for Hookworm vs 7.2% (p < 0.001), 11% for Trichuris compared to 5.2% (p < 0.001), 13.2% compared to 7.5% for S. stercoralis (p < 0.05), and 12% compared to 6% for Ascaris cases (p < 0.05). Helminths and non pathogenic protozoa, as single or mixed infections, occurred among the participants. There was a strong correlation between eosinophilia and helminthiasis infections; however, none was identified between CD4 levels and eosinophilia. Because parasitic infections aggravate malnutrition and promote a disbalanced Th2 response in a potentially immuno-compromised host, their effect on HIV disease progression needs further study, mainly in countries were HIV and parasitic infections are highly prevalent.
Failure in generating hemopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host. (1988)

We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that CMV infection interferes with the earliest detectable step in hemopoiesis, the generation of the stem cell CFU-S-I, and thereby prevents the autoreconstitution of bone marrow after sublethal irradiation. The antihemopoietic effect could not be ascribed to a direct infection of stem cells. The failure in hemopoiesis was prevented by adoptive transfer of antiviral CD8+ T lymphocytes and could be overcome by syngeneic bone marrow transplantation. CD8+ T lymphocytes and bone marrow cells both mediated survival, although only CD8+ T lymphocytes were able to limit virus multiplication in host tissues. We concluded that not the cytopathic effect of virus replication in host tissues, but the failure in hemopoiesis, is the primary cause of death in murine CMV disease.
Sensoren im Kraftfahrzeug (2010)

Der Begriff Sensor führte sich ein, als in den zurückliegenden 20…40 Jahren Messfühler auch in Konsumanwendungen (z. B. Kraftfahrzeug und Hausgerätetechnik) einzogen. Sensoren – begrifflich identisch mit (Mess-)Fühlern und (Messwert-)Aufnehmern – setzen eine physikalische oder chemische (meist nichtelektrische) Größe Φ in eine elektrische Größe E um; dies geschieht oft auch über weitere, nichtelektrische Zwischenstufen.
Using synthetic data safely in classification (2008)

When is it safe to use synthetic training data in supervised classification? Trainable classifier technologies require large representative training sets consisting of samples labeled with their true class. Acquiring such training sets is difficult and costly. One way to alleviate this problem is to enlarge training sets by generating artificial, synthetic samples. Of course this immediately raises many questions, perhaps the first being "Why should we trust artificially generated data to be an accurate representative of the real distributions?" Other questions include "When will training on synthetic data work as well as - or better than training on real data ?". We distinguish between sample space (the set of real samples), parameter space (all samples that can be generated synthetically), and finally, feature space (the set of samples in terms of finite numerical values). In this paper, we discuss a series of experiments, in which we produced synthetic data in parameter space, that is, by convex interpolation among the generating parameters for samples and showed we could amplify real data to produce a classifier that is as accurate as a classifier trained on real data. Specifically, we have explored the feasibility of varying the generating parameters for Knuth's Metafont system to see if previously unseen fonts could also be recognized. We also varied parameters for an image quality model. We have found that training on interpolated data is for the most part safe, that is to say never produced more errors. Furthermore, the classifier trained on interpolated data often improved class accuracy.
Founder Centrality and Strategic Behavior in the Family-Owned Firm (2000)

This paper explores how founders influence strategic management in the family business. The authors suggest it is essential to consider the central influence of a family firm's founder on the top management group and on the firm's strategic values, goals, and behavior. They further posit that a founder can be expected to shape the family firm's interactions with the external environment. The authors explore the central role that a founder plays in a family business from a social network perspective and establish the basis for the founder centrality concept. Further, they develop a framework and propositions from which the founder's influence on strategic behavior and performance may be studied.
Alternative Sigma Factors and Their Roles in Bacterial Virulence (2005)

Sigma factors provide promoter recognition specificity to RNA polymerase holoenzyme, contribute to DNA strand separation, and then dissociate from the core enzyme following transcription initiation. As the regulon of a single sigma factor can be composed of hundreds of genes, sigma factors can provide effective mechanisms for simultaneously regulating expression of large numbers of prokaryotic genes. One newly emerging field is identification of the specific roles of alternative sigma factors in regulating expression of virulence genes and virulence-associated genes in bacterial pathogens. Virulence genes encode proteins whose functions are essential for the bacterium to effectively establish an infection in a host organism. In contrast, virulence-associated genes can contribute to bacterial survival in the environment and therefore may enhance the capacity of the bacterium to spread to new individuals or to survive passage through a host organism. As alternative sigma factors have been shown to regulate expression of both virulence and virulence-associated genes, these proteins can contribute both directly and indirectly to bacterial virulence. Sigma factors are classified into two structurally unrelated families, the sigma70 and the sigma54 families. The sigma70 family includes primary sigma factors (e.g., Bacillus subtilis sigma(A)) as well as related alternative sigma factors; sigma54 forms a distinct subfamily of sigma factors referred to as sigma(N) in almost all species for which these proteins have been characterized to date. We present several examples of alternative sigma factors that have been shown to contribute to virulence in at least one organism. For each sigma factor, when applicable, examples are drawn from multiple species.
Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF (2015)

TRIM24 is a transcriptional regulator as well as an E3 ubiquitin ligase. It is overexpressed in diverse tumors, and high expression levels have been linked to poor prognosis in breast cancer patients. TRIM24 contains a PHD/bromodomain offering the opportunity to develop protein interaction inhibitors that target this protein interaction module. Here we identified potent acetyl-lysine mimetic benzimidazolones TRIM24 bromodomain inhibitors. The best compound of this series is a selective BRPF1B/TRIM24 dual inhibitor that bound with a KD of 137 and 222 nM, respectively, but exerted good selectivity over other bromodomains. Cellular activity of the inhibitor was demonstrated using FRAP assays as well as cell viability data.
Switching Memories ON and OFF (2008)

Control of new protein synthesis regulates whether an experience is translated into a long-term memory.
Long-Term PMD Characterization of a Metropolitan G.652 Fiber Plant (2006)

Using the Jones matrix eigenanalysis method, the differential group delay (DGD) behavior of a metropolitan G.652 buried operational cable plant of a major Italian telecom operator in the city of Torino was characterized. The measurement campaign lasted 73 consecutive days. An extremely stable DGD behavior was found, despite the fact that the cables run across a very densely built city environment. On the other hand, it was also found that routine maintenance on the infrastructure, although indirect and nondisruptive, repeatedly altered this picture. Based on these results, it is argued that the recently introduced "hinge" model describes the plant DGD statistical behavior better than the traditional description. This argument is also supported by the close fit that was obtained with a theoretical hinge-model DGD probability density function of the measured DGD data histogram. It is also argued that in this kind of scenario fast adaptive compensation is most likely the only realistic solution for avoiding sudden performance degradation or out-of-service
Bivalent ligand type beta-adrenolytics related to practolol. (1988)

The synthesis and pharmacological evaluation of a number of symmetrical bivalent ligand type beta-adrenolytics related to practolol are reported. The best results have been observed with N,N'-bis[3-[2-hydroxy-3-[1-methylethyl)amino]propoxy]phenyl] ethanediamide.
A multiplex PCR assay for the simultaneous detection and discrimination of the seven<i>Eimeria</i>species that infect domestic fowl (2003)

This study reports the development of a novel multiplex PCR assay based on SCAR (Sequence-Characterised Amplified Region) markers for the simultaneous diagnosis of the 7 Eimeria species that infect domestic fowl. Primer pairs specific for each species were designed in order to generate a ladder of amplification products ranging from 200 to 811 bp. Sensitivity tests for each species were carried out, showing a detection threshold of 1-5 pg, which corresponds approximately to 2-8 sporulated oocysts. Distinct isolates of the 7 Eimeria species from different geographical sources were tested and successfully detected by the assay. All the species were amplified homogeneously, whether or not one of them was present in a high quantity, indicating that there was no cross-interference. The assay was also tested with different sources of Taq DNA polymerase and thermocycler models, confirming the high reproducibility of the reaction. The economy of consumables and labour represented by a single-tube reaction greatly facilitates the molecular diagnosis of a large number of samples, making it appropriate for field epizootiological surveys. We propose the use of this multiplex PCR assay as a rapid and cost-effective diagnostic method for the detection and discrimination of the 7 Eimeria species that infect domestic fowl.