gebhart/patrepeval huggingface dataset:
3‐D Hale‐McClellan prestack depth migration with enhanced extrapolation operators (2000)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 20003‐D Hale‐McClellan prestack depth migration with enhanced extrapolation operatorsAuthors: Zhaobo MengNorman Daniel WhitmorePaul A. ValasekYunqing ShenKay D. WyattWei LiuZhaobo MengPhillips Petroleum, Norman Daniel WhitmoreAxis Imaging, Paul A. ValasekPhillips Petroleum, Yunqing ShenPhillips Petroleum, Kay D. WyattPhillips Petroleum, and Wei Liu3D Geohttps://doi.org/10.1190/1.1816102 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1816102FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 2000ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2000 Pages: 2484 publication data© 2000 Copyright © 2000 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 04 Jan 2005 CITATION INFORMATION Zhaobo Meng, Norman Daniel Whitmore, Jr., Paul A. Valasek, Yunqing Shen, Kay D. Wyatt, and Wei Liu, (2000), "3‐D Hale‐McClellan prestack depth migration with enhanced extrapolation operators," SEG Technical Program Expanded Abstracts : 485-488. https://doi.org/10.1190/1.1816102 Plain-Language Summary PDF DownloadLoading ...
Structure and function in rhodopsin: High-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible <i>N</i> -acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line (2002)

An HEK293S cell line resistant to ricin was prepared by mutagenesis by using ethyl methanesulfonate. It was shown to lack N-acetylglucosaminyltransferase I (GnTI) activity, and consequently unable to synthesize complex N-glycans. The tetracycline-inducible opsin expression system was assembled into this GnTI(-) HEK293S cell line. Stable cell lines were isolated that gave tetracycline/sodium butyrate-inducible expression of the WT opsin gene at levels comparable with those observed in the parent tetracycline-inducible HEK293S cell line. Analysis of the N-glycan in rhodopsin expressed by the HEK293S GnTI(-) stable cell line showed it to be Man(5)GlcNAc(2). In a larger-scale expression experiment (1.1 liter) a WT opsin production level of 6 mg/liter was obtained. Further, the toxic constitutively active rhodopsin mutant, E113Q/E134Q/M257Y, previously shown to require inducible expression, has now been expressed in an HEK293S GNTI(-)-inducible cell line at levels comparable with those obtained with WT rhodopsin.
Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin (2017)

Inhibitors of HDAC6 have attractive potential in numerous cancers. HDAC6 inhibitors to date target the catalytic domains, but targeting the unique zinc-finger ubiquitin-binding domain (Zf-UBD) of HDAC6 may be an attractive alternative strategy. We developed X-ray crystallography and biophysical assays to identify and characterize small molecules capable of binding to the Zf-UBD and competing with ubiquitin binding. Our results revealed two adjacent ligand-able pockets of HDAC6 Zf-UBD and the first functional ligands for this domain.
Bookmark-driven Query Routing in Peer-to-Peer Web Search (2004)

Abstract: We consider the problem of collaborative Web search and query routing strategies in a peer-to-peer (P2P) environment. In our architecture every peer has a full-fledged search engine with a (thematically focused) crawler and a local index whose contents may be tailored to the user’s specific interest profile. Peers are autonomous and post meta-information about their bookmarks and index lists to a global directory, which is efficiently implemented in a decentralized manner using Chordstyle distributed hash tables. A query posed by one peer is first evaluated locally; if the result is unsatisfactory the query is forwarded to selected peers. These peers are chosen based on a benefit/cost measure where benefit reflects the thematic similarity of peers ’ interest profiles, derived from bookmarks, and cost captures estimated peer load and response time. The meta-information that is needed for making these query routing decisions is efficiently looked up in the global directory; it can also be cached and proactively disseminated for higher availability and reduced network load. 1
Indium Segregation in MOVPE Grown InGaN‐Based Heterostructures (2002)

We have studied theoretically the MOVPE of GaN/InGaN/(Al)GaN quantum well structures with the focus on transient processes. The detailed model of surface kinetics is used to examine the effect of barrier layer and growth conditions on the distribution of indium and aluminum composition across a structure. The model predictions are compared to available experimental data and possible ways for improvement of the quantum well composition uniformity are discussed.
Criteria for use of valproate in adult psychiatric inpatients and outpatients (1996)

Journal Article Criteria for use of valproate in adult psychiatric inpatients and outpatients Get access Talia Puzantian, Pharm.D. Talia Puzantian, Pharm.D. Clinical Pharmacy Specialist in Psychiatry, Department of Pharmacy Services (119), Veterans Affairs Health Care Svstem Palo Alto, 3801 Miranda Avenue, Palo Alto, CA 94304. Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 53, Issue 10, 15 May 1996, Pages 1187–1191, https://doi.org/10.1093/ajhp/53.10.1187 Published: 15 May 1996
The Interaction Between Humans and Autonomous Agents (2016)

Humans represent knowledge and learning experiences in the form of mental models. This concept from the field of cognitive psychology is one of the central theoretical paradigms for understanding and designing the interaction between humans and technical systems.
Fluorinated Chiral Secondary Amines as Catalysts for Epoxidation of Olefins with Oxone (2005)

We have synthesized a series of chiral cyclic secondary amines having different substitution patterns and have screened them as catalysts for the asymmetric epoxidation of olefins using Oxone. The highest enantiomeric excess (61%) occurred for the epoxidation of 1-phenylcyclohexene catalyzed by a secondary amine bearing a fluorine atom at the beta-position relative to the amino center. Our experimental results provide further support to the notion that the amine plays a dual role--as a phase transfer catalyst and an Oxone activator--in these epoxidation reactions. The slightly acidic reaction conditions we employed in this work obviate the need to preform ammonium salts, which are the actual catalysts that mediate the epoxidations.
Feldkamp‐type VOI reconstruction from super‐short‐scan cone‐beam data (2004)

Based on the fan-beam reconstruction formula recently developed by Noo et al. [Phys. Med. Biol. 47, 2525-2546 (2002)] we develop a Feldkamp-type algorithm for the reconstruction of a volume of interest (VOI) from super-short-scan data. With either a circular or spiral scanning locus in our VOI reconstruction scheme, we first estimate fan-beam data from cone-beam data using the popular "cosine correction" scheme, and perform reconstruction based on Noo's FBP-type fan-beam reconstruction. Our proposed algorithm is tested using the three-dimensional (3-D) Shepp-Logan phantom. The experimental results show that the new algorithm can be applied to multi-source 4-D CT with significantly superior temporal resolution and temporal consistency relative to the Katsevich algorithm, which is the state of the art for exact helical cone-beam reconstruction.
Spatial resolution of diffraction tomography (1997)

Diffraction tomography is an imaging technique applicable to crosshole seismic data and aimed at achieving optimal spatial resolution away from the borehole. In principle the method can form acoustic images equivalent to extending acoustic well logs away from the wellbore and into the formation with a spatial resolution less than one wavelength of the radiation employed to gather the crosshole data. This paper reports on the capability of diffraction tomography to produce high-resolution reconstructions of simple targets from limited-view-angle data. The goal is to quantify the resolution and velocity-reconstruction capability of diffraction tomography with realistic source–receiver geometries. Simple targets (disks and low-contrast sequences of layers) are used for this study. The scattering from these targets can be calculated without approximation, making them ideal test cases for the algorithm. The resolution capability of diffraction tomography is determined to be on the order of one wavelength for several experimental geometries. It is shown that the image-formation characteristics of diffraction tomography, in terms of its ability to determine object boundaries and velocities, are closely related to the experimental geometry. Reflection and vertical seismic profiling (VSP) experiments tend to reproduce boundaries well, while crosshole experiments give the best overall reconstruction of both target boundaries and velocity. The quantitative accuracy of the velocity reconstruction depends upon the match between the spatial-frequency content of the object and the spatial-frequency response of the algorithm. For some targets, the velocity cannot be correctly reproduced from limited-view-angle data.
Large Diameter Coiled Tubing Becomes Available Safely Offshore Through a Newly Developed Spoolable Connector: Case Histories and Field Implementation (2005)

Abstract Coiled Tubing operations in the North Sea are regularly challenged by crane lift capacity limitations when attempting to bring coiled tubing reels onboard. Very often the crane capacity or weather conditions determine the CT size to be used for the application, leading to operations conducted with less then the optimum CT size. The Norwegian sector generally has larger capacity cranes but most operations regularly involve the use of large OD coiled tubing (2.375" or 2.875"). The lengths required can cause logistical problems due to the lifting weights of the CT reels used. Current methods utilised for keeping weights as low as possible involve using so called split reel systems and thin-walled high strength parallel CT strings (i.e. constant wall thickness). While these weight reducing measures have proven themselves for many years now in the Norwegian sector, they can not resolve equipment weight issues in all cases. The joining of 2 or more separate strings together offshore by installing butt welds has been standard practice in the UK sector for many years now, mainly involving CT sizes of up to 1.75". In the Norwegian sector, butt-weld failures have occurred when using larger CT sizes and operators have been seeking a viable option to butt-welding, especially for larger OD CT. In response to a direct request by the BJ Services North Sea operations departments, BJ Services Coiled Tubing Research & Engineering group in Calgary, Canada have developed and commercialised a LCF (Low Cycle Fatigue) Spoolable Connector to replace offshore butt-welding and resolve weight issues associated with heavy CT reels.
Three-dimensional Organization of pKi-67: A Comparative Fluorescence and Electron Tomography Study Using Fluoronanogold (2003)

The monoclonal antibody (MAb) Ki-67 is routinely used in clinical studies to estimate the growth fraction of tumors. However, the role of pKi-67, the protein detected by the Ki-67 MAb, remains elusive, although some biochemical data strongly suggest that it might organize chromatin. To better understand the functional organization of pKi-67, we studied its three-dimensional distribution in interphase cells by confocal microscopy and electron tomography. FluoroNanogold, a single probe combining a dense marker with a fluorescent dye, was used to investigate pKi-67 organization at the optical and ultrastructural levels. Observation by confocal microscopy followed by 3D reconstruction showed that pKi-67 forms a shell around the nucleoli. Double labeling experiments revealed that pKi-67 co-localizes with perinucleolar heterochromatin. Electron microscopy studies confirmed this close association and demonstrated that pKi-67 is located neither in the fibrillar nor in the granular components of the nucleolus. Finally, spatial analyses by electron tomography showed that pKi-67 forms cords 250-300 nm in diameter, which are themselves composed of 30-50-nm-thick fibers. These detailed comparative in situ analyses strongly suggest the involvement of pKi-67 in the higher-order organization of perinucleolar chromatin.
Conformationally Constrained 1,3-Diamino Ketones:  A Series of Potent Inhibitors of the Cysteine Protease Cathepsin K (1998)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTConformationally Constrained 1,3-Diamino Ketones: A Series of Potent Inhibitors of the Cysteine Protease Cathepsin KRobert W. Marquis, Dennis S. Yamashita, Yu Ru, Stephen M. LoCastro, Hye-Ja Oh, Karl F. Erhard, Renee L. DesJarlais, Martha S. Head, Ward W. Smith, Baoguang Zhao, Cheryl A. Janson, Sherin S. Abdel-Meguid, Thaddeus A. Tomaszek, Mark A. Levy, and Daniel F. VeberView Author Information Departments of Medicinal Chemistry, Structural and Physical Chemistry, Structural Biology, and Molecular Recognition, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406 Cite this: J. Med. Chem. 1998, 41, 19, 3563–3567Publication Date (Web):August 19, 1998Publication History Received11 May 1998Published online19 August 1998Published inissue 1 September 1998https://doi.org/10.1021/jm980295fCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views754Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (191 KB) Get e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Anatomy,Inhibitors,Ketones,Molecular structure,Peptides and proteins Get e-Alerts
Structural analysis of convolutional codes via dual codes (1973)

A linear correspondence is developed between the states of a rate- <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k/n</tex> convolutional encoder <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">G</tex> and the states of a corresponding syndrome former <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H^T</tex> , where <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</tex> is an encoder of the code dual to the code generated by <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">G</tex> . This correspondence is used to find an expression for the number of all-zero paths of length <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\tau</tex> in the code trellis; the answer depends only on the constraint lengths of the dual code. A partial answer to the resynchronization problem also falls out of this development.
The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. (1995)

During mitosis in Ptk1 cells anaphase is not initiated until, on average, 23 +/- 1 min after the last monooriented chromosome acquires a bipolar attachment to the spindle--an event that may require 3 h (Rieder, C. L., A. Schultz, R. W. Cole, and G. Sluder. 1994. J. Cell Biol. 127:1301-1310). To determine the nature of this cell-cycle checkpoint signal, and its site of production, we followed PtK1 cells by video microscopy prior to and after destroying specific chromosomal regions by laser irradiation. The checkpoint was relieved, and cells entered anaphase, 17 +/- 1 min after the centromere (and both of its associated sister kinetochores) was destroyed on the last monooriented chromosome. Thus, the checkpoint mechanism monitors an inhibitor of anaphase produced in the centromere of monooriented chromosomes. Next, in the presence of one monooriented chromosome, we destroyed one kinetochore on a bioriented chromosome to create a second monooriented chromosome lacking an unattached kinetochore. Under this condition anaphase began in the presence of the experimentally created monooriented chromosome 24 +/- 1.5 min after the nonirradiated monooriented chromosome bioriented. This result reveals that the checkpoint signal is not generated by the attached kinetochore of a monooriented chromosome or throughout the centromere volume. Finally, we selectively destroyed the unattached kinetochore on the last monooriented chromosome. Under this condition cells entered anaphase 20 +/- 2.5 min after the operation, without congressing the irradiated chromosome. Correlative light microscopy/elctron microscopy of these cells in anaphase confirmed the absence of a kinetochore on the unattached chromatid. Together, our data reveal that molecules in or near the unattached kinetochore of a monooriented PtK1 chromosome inhibit the metaphase-anaphase transition.
New Resin Acid Derivatives: Diisocyanate, Diurethanes and Diureides (1998)

Abstract New difunctional resin acids derivatives, diisocyanate, diurethanes and diureides were obtained via nitration of dehydroabietic acid followed by catalytic hydrogenation or reduction; carbonylation of the resulting amine and further reaction of the new diisocyanate with alcohols or amines.
Nonsynonymous Coding Single-Nucleotide Polymorphisms Spanning the Genome in Relation to Glioblastoma Survival and Age at Diagnosis (2007)

Although limited by a relatively small sample size, this pilot study, using well-characterized, unambiguous disease characteristics, illustrates the necessity of independent replication owing to the likelihood of false positives. Several other challenges are discussed, including attempts to incorporate information on the potential functional importance of SNPs in genome-disease association studies.
Multielectrode spiral cuff for ordered and reversed activation of nerve fibres (1993)

In this paper we present the modelling, design, and experimental testing of a nerve cuff multielectrode system for selective activation of fibres in superficial peripheral nerve trunk regions which is capable of activating fibres in physiological order. The multielectrode system consists of 45 platinum electrodes embedded within a self-curling spiral silicone sheet organized in fifteen longitudinal groups consisting of three electrodes spaced equidistally around the circumference of the cuff. Electrodes in the centre band acted as stimulating cathodes while the two electrodes of the same group in the two outer bands were connected together and corresponded to the position of a particular cathode, serving as anodes to block the nascent action potentials by membrane hyperpolarization. The interpolar distance was 6 mm on both sides, resulting in a total cuff length of about 20 mm. The cuff was constructed with a diameter to fit the size of the dog sciatic nerve. Preliminary animal testing of the nerve cuff was performed on the sciatic nerve of a Bigley female dog. In the 45-electrode stimulation system, biphasic cathodic first pulses with quasitrapezoidal-shaped cathodic and square anodic parts were delivered through the particular group of tripolar electrodes to effect both selective stimulation of motor axons within the gastrocnemius muscle fascicle, and differential block by membrane hyperpolarization. The test was repeated using rectangular cathodic first biphasic current pulses delivered monopolarly on the central electrode of the same group while connected anodes were replaced by a common anode situated elsewhere in the surrounding tissue. In both experiments an isometric torque in the ankle joint elicited by the gastrocnemius muscle was measured and compared.(ABSTRACT TRUNCATED AT 250 WORDS)
DronePilot.NET Development: AR.Drone SDK Supporting Native and Managed Code (2013)

AR.Drone is a remote-controlled quad-rotor helicopter that is operated by computer instruction. Because communications between AR.Drone and a computer are complex, it is difficult to program AR.Drone software. Existing software development kits (SDKs) reduce those complexities, however, SDKs have many limitations. They can be difficult to use because the structure is too complex to understand, or their extensibility is too minimal for making a multifunctional application. To address these problems, we developed the new DronePilot.NET SDK. The DronePilot.NET SDK supports managed code, and it enables creation of user application programs using C# and Visual Basic. Moreover, because the proposed SDK includes code written in C++/CLI, it supports unmanaged code and enables direct access to native libraries. In addition, the DronePilot.NET SDK supports high-definition video data, image analysis by OpenCV, marker recognition by ARToolkit, and 3D object display by OpenGL. We measured the performance of our proposed SDK for processing video images and have verified its satisfactory performance.
Clonidine and Naltrexone in the Outpatient Treatment of Heroin Withdrawal (1987)

Clonidine hydrochloride (an alpha-2 adrenergic agonist) and naltrexone hydrochloride (an opioid antagonist), given in combination, provided a safe and effective treatment of abrupt opioid withdrawal over 5 days in an outpatient/day setting. Before starting the clonidine, a naloxone challenge test was used to verify and quantify opioid dependence, and the naloxone challenge test score was then used to determine initial medication doses. Initial naloxone challenge test scores predicted subsequent patient discomfort during the 5-day clonidine-naltrexone protocol. Twelve of 14 (86%) heroin users successfully withdrew from opioids and simultaneously initiated naltrexone maintenance.
A programmed functional and phenotypic development of bone marrow‐derived cytotoxic cell precursors <i>in vitro</i> (1987)

An analysis of function and marker expression during cytotoxic cell differentiation in vitro from T cell-depleted bone marrow precursors is described. Cytotoxic activity is not detectable during the first five days of culture, but rises abruptly soon after. Antibody plus complement depletion studies show that cytotoxic cells derive from Thy-1-negative precursors and undergo a continual increase in Thy-1 and Lyt-2 marker expression as the culture progresses. A reciprocal decrease in asialo-GM1 antigen expression on effector cells is seen. The J11d-negative precursor cells acquire J11d (an antigen known to mark cortical thymocytes) at an intermediate stage of culture, but revert to the J11d-negative phenotype prior to functional acquisition. At least some effectors are T cell receptor positive as illustrated by an anti-T cell receptor antibody-mediated killing assay. These patterns precisely correlate with those detected among developing T cells in vivo. Results may indicate that a programmed course of differentiation inherent to bone marrow cells may be triggered in the absence of a thymic environment.