gebhart/patrepeval huggingface dataset:
Lock-Free Synchronization for Dynamic Embedded Real-Time Systems (2006)

We consider lock-free synchronization for dynamic embedded real-time systems that are subject to resource overloads and arbitrary activity arrivals. We model activity arrival behaviors using the unimodal arbitrary arrival model (or UAM). UAM embodies a stronger“adversary” than most traditional arrival models. We derive the upper bound on lock-free retries under the UAM with utility accrual scheduling—the first such result. We establish the tradeoffs between lock-free and lock-based sharing under UAM. These include conditions under which activities’accrued timeliness utility is greater under lock-free than lock-based, and the consequent upper bound on the increase in accrued utility that is possible with lock-free. We confirm our analytical results with a POSIX RTOS implementation.
Clock Network Power Saving Using Multi-Bit Flip-Flops in Multiple Voltage Island Design (2013)

Power consumption is an important issue in modern high-frequency and low power design. Multi-bit flip-flops are used to reduce the clock system power. The scaling with multiple supply voltage is an effective way to minimize the dynamic power consumption. In this paper, we propose an effective multi-bit flip-flops merging approach to deal with the clock network power minimization problem and an placement method to avoid placing flip-flops in the congestion bins. Moreover, the proposed approach can be applied to both single and multiple supply voltage designs. Experimental results show that our approach can reduced the clock power up to 25%. In addition, for multiple supply voltage designs, the proposed approach can reduce the number of level shifters significantly.
Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer (2009)

These observations suggest that FASN can act as a prostate cancer oncogene in the presence of AR and that FASN exerts its oncogenic effect by inhibiting the intrinsic pathway of apoptosis.
Aerodynamic performance of scarf inlets (1979)

A scarf inlet is characterized by having a longer lower lip than upper lip leading to both aerodynamic and acoustic advantages. Aerodynamically, a scarf inlet has higher angle of attack capability and is less likely to ingest foreign objects while the aircraft is on the ground. Acoustically, a scarf inlet provides for reduced inlet radiated noise levels below the engine as a result of upward reflection and refraction of inlet radiated noise. Results of a wind tunnel test program are presented which illustrate the aerodynamic performance of two different scarf inlet designs. Based on these results, scarf inlet performance is summarized in a way to illustrate the advantages and limitations of a scarf inlet compared to an axisymmetric inlet.
Modulation of Cellular Tropism and Innate Antiviral Response by Viral Glycans (2009)

Arthropod-borne viruses (arboviruses) are a significant cause of human and animal disease worldwide. Multiple interactions between virus and the host innate immune system ultimately determine the pathogenesis and clinical outcome of the infection. Evidence is rapidly emerging that suggests viral glycans play a key role in viral pathogenesis by regulating host cell tropism and interactions with the host innate immune response. Glycan-mediated interactions are especially important for arboviruses which must adapt to variable glycosylation systems and cellular receptors within both vertebrate and invertebrate hosts. This review focuses on emerging evidence which supports a crucial role for viral glycans in mediating host cell tropism and regulating the innate antiviral response.
Tongue piercing: case report and ethical overview. (2004)

A case of infection following piercing of the tongue is presented. A dentist allegedly provided local anesthesia to the tongue prior to piercing. To avoid criticism from the first dentist, the patient saw a different dentist to treat the infection. The patient had symptoms of pain, inflammation, purulence, salivary incontinence, and difficulty speaking and swallowing. The ornament was discarded and the infection was resolved with antibiotic therapy. Ethical issues of administering anesthesia prior to piercing also are discussed.
Automatic diagnosis of melanoma using machine learning methods on a spectroscopic system (2014)

Our work has two strengths. (1) We have used single scattered polarized light spectroscopy and multiple scattered unpolarized light spectroscopy to decipher the multilayered characteristics of human skin. (2) Our approach does not need image segmentation, as we directly probe tiny spots in the lesion skin and the image scans do not involve background skin. The desktop application for automatic diagnosis of melanoma can help dermatologists get a non-subjective second opinion for their diagnosis decision.
Extractive Dialogue Summarization Without Annotation Based on Distantly Supervised Machine Reading Comprehension in Customer Service (2021)

Given a long dialogue, the dialogue summarization system aims to obtain a shorter highlight which retains the important information in the original text. For the customer service scenarios, the summaries of most dialogues between an agent and a user focus on several fixed key points, such as users’ question, users’ purpose, the agent’s solution, and so on. Traditional extractive methods are difficult to extract all predefined key points exactly. Furthermore, there is a lack of large-scale and high-quality extractive summarization datasets containing the annotation for key points. Moreover, the speaker’s role information is ignored or not fully utilized in previous work. In order to solve the above challenges, we propose a Distant Supervision based Machine Reading Comprehension model for extractive Summarization (DSMRC-S). DSMRC-S transforms the summarization task into the machine reading comprehension problem, to fetch key points from the original text exactly according to the predefined questions. In addition, a distant supervision method is proposed to alleviate the lack of eligible extractive summarization datasets. What’s more, a speaker’s role token and the solver classification task are proposed to make full use of speaker’s role information. We conduct experiments on a real-world summarization dataset collected in customer service scenarios, and the results show that the proposed method outperforms the strong baseline methods by 6 percentage points on ROUGE <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$_L$</tex-math></inline-formula> .
Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model (2016)

RNA-based cancer therapies are hindered by the lack of delivery vehicles that avoid cancer-induced organ dysfunction, which exacerbates carrier toxicity. We address this issue by reporting modular degradable dendrimers that achieve the required combination of high potency to tumors and low hepatotoxicity to provide a pronounced survival benefit in an aggressive genetic cancer model. More than 1,500 dendrimers were synthesized using sequential, orthogonal reactions where ester degradability was systematically integrated with chemically diversified cores, peripheries, and generations. A lead dendrimer, 5A2-SC8, provided a broad therapeutic window: identified as potent [EC50 < 0.02 mg/kg siRNA against FVII (siFVII)] in dose-response experiments, and well tolerated in separate toxicity studies in chronically ill mice bearing MYC-driven tumors (>75 mg/kg dendrimer repeated dosing). Delivery of let-7 g microRNA (miRNA) mimic inhibited tumor growth and dramatically extended survival. Efficacy stemmed from a combination of a small RNA with the dendrimer's own negligible toxicity, therefore illuminating an underappreciated complication in treating cancer with RNA-based drugs.
Low-Latency Decoding of EG LDPC Codes (2007)

We describe simple iterative decoders for low-density parity-check codes based on Euclidean geometries, suitable for practical very-large-scale-integration implementation in applications requiring very fast decoders. The decoders are based on shuffled and replica-shuffled versions of iterative bit-flipping (BF) and quantized weighted BF schemes. The proposed decoders converge faster and provide better ultimate performance than standard BF decoders. We present simulations that illustrate the performance versus complexity tradeoffs for these decoders. We can show in some cases through importance sampling that no significant error floor exists.
A novel treatment strategy for ovarian cancer based on immunization against zona pellucida protein (ZP) 3 (2011)

We tested the principle of treating malignant ovarian tumors by vaccination against their ectopically expressed protein, zona pellucida glycoprotein (ZP) 3, using as the experimental model the granulosa cell tumors that develop in transgenic mice expressing the simian virus 40 T-antigen under the inhibin-α promoter (inhα/Tag). We found high ZP3 expression in granulosa cell tumors of the transgenic mice, in human surface ovarian cancer and granulosa cell lines, and in human granulosa cell tumors and their metastases. Early preventive immunization (between 2 and 5.5 mo of age) of transgenic mice with recombinant human (rh) ZP3 prevented ovarian tumorigenesis, and delayed therapeutic immunization (between 4.5 and 7 mo) reduced weights of existing tumors by 86 and 75%, respectively (P<0.001), compared to vehicle-treated control mice. No objective side effects of the immunizations were observed. Liver metastases were found in nontreated/vehicle-treated controls (n=7/39), but none following active rhZP3 immunizations (n=0/36; P<0.05). Immunization with rhZP3 was highly effective, as demonstrated by the induction of anti-ZP3 antibodies, as well as proliferative responses to the ZP3 antigen. These results signal rhZP3 immunization as a novel strategy to be developed for the immunotherapy of ovarian granulosa cell tumors, as well as for that of other malignancies that may express ZP3.
An identification technique for data acquisition characterization in the presence of nonlinear distortions and time base distortions (2001)

The nonlinear behavior of data acquisition channels and analog-to-digital converters is often measured using sine-wave measurements. High-frequency sampling scopes also suffer from time base distortions. This implies that the signals are sampled at a nonequidistant time grid. This paper describes a robust and efficient identification technique to characterize acquisition channels which suffer from both nonlinear distortions and/or time base distortions in the presence of both additive and jitter noise. An automatic model selection scheme and the generation of uncertainty bounds are obtained through the statistical properties of the proposed simulator. The applicability of the method is demonstrated on both simulations and measurements of high-frequency sampling scopes.
Adaptive Scheduling of Message Carrying in a Pigeon Network (2010)

In adverse environments where real-time communications are not always available, a delay tolerant network may be the only choice. A special type of delay tolerant network known as a ``pigeon network'' utilizes controllable special purpose vehicles called ``pigeons'' to convey messages among segregated areas. A challenging problem studied in this paper is how to schedule a ``pigeon'' to enter/leave a particular segregated area in an optimal way so that the average delay of messages is minimized. This problem falls in the range of server vacation queueing model. Unfortunately, the amount of work in the open literature that addresses the optimal scheduling (service discipline) problem is very limited, especially when bursty traffic is considered. Based on an analysis of a scenario with deterministic and Poisson arrivals, we propose an adaptive scheduling scheme that alternates the service disciplines according to the trend of message accumulation on the home/foreign host. This adaptive scheme shows good performance and flexibility in adjusting to the dynamics of bursty and non-bursty traffic.
The Specificity of Pancreatic Deoxyribonuclease (1973)

The kinetics of degradation of calf thymus DNA by pancreatic DNAase has been investigated with the main purpose of providing the background for studying the specificity of the enzyme and its use in investigations of nucleotide sequences in DNA. The relationships between the hyperchromic shift or acid solubility and the reciprocal average degree of polymerization (P̄ n −1 ) of the hydrolysate have been established; these can be used in order to prepare oligonucleotides of desired average chain length simply by measuring the increase of absorbance or of acid solubility of the digest during DNA degradation. The specificity of the pancreatic DNAase was studied by determining the base compositions of 3′‐terminal, 5′‐terminal and 5′‐penultimate nucleotides of oligonucleotides released by the enzyme. The 3′‐terminal nucleotide composition was found not to vary in the P̄ n , or average size, range 150 to 8 and 30 to 8 for digestions of calf thymus DNA in the presence of magnesium and manganese ions, respectively, indicating that no change in the specificity takes place during digestion. The compositions of 3′‐terminal, 5′‐terminal and 5′‐penultimate nucleotides differ from those expected on the basis of random splitting of DNA. The conclusion is drawn that pancreatic DNAase recognizes sequences at least three nucleotides long.
Mendelian cytogenetics. Chromosome rearrangements associated with mendelian disorders. (1993)

The first successful mapping of a mendelian disorder by chromosome rearrangements was that of the Duchenne muscular dystrophy locus to Xp21.1-5 Since then, chromosome ab- errations which delete, truncate, or otherwise rearrange and mutate specific genes have not only helped in the mapping of other disease loci,6 but have turned out to be key elements for the rapid isolation of disease genes by positional cloning strategies.7 Accordingly, a listing of the clinical disorders in which associated chromosome rearrangements have been described forms a part of the Human Gene Mapping Workshops.6 Although the early suc- cess led to a proposal for systematic cytogene- tic analysis of subjects with mendelian dis- orders,8 this has rarely been done. A common feeling is that, as mutations, these rearrange- ments are rare exceptions. The aim of the present review is to document that they may be rare, but are not exceptions, and to focus on factors which may influence their occurrence and facilitate their detection.
PHOTODIMERIZATION OF 4′-FORMYL-4-STILBAZOLE COMPOUNDS IN SOLID MEDIA (1994)

Phototodimerizatins of four Stibazole compouds(FSA)in different polymer films werestudied.The results of absorption and emission spectra show that the compouds possessstronger molecular aggregation which will affect photochemical behaviors of FSA singnificantly.The photodimerizattion rates of FSA in solid media will depend on the molecular structure,concentration and micro-environment properties.Under the given condition,itis possible to prepare a new kind of photo crosslinking system with high photoresponse.
Formaldehyde Fixation Contributes to Detoxification for Growth of a Nonmethylotroph, <i>Burkholderia cepacia</i> TM1, on Vanillic Acid (2003)

During bacterial degradation of methoxylated lignin monomers, such as vanillin and vanillic acid, formaldehyde is released through the reaction catalyzed by vanillic acid demethylase. When Burkholderia cepacia TM1 was grown on vanillin or vanillic acid as the sole carbon source, the enzymes 3-hexulose-6-phosphate synthase (HPS) and 6-phospho-3-hexuloisomerase (PHI) were induced. These enzymes were also expressed during growth on Luria-Bertani medium containing formaldehyde. To understand the roles of these enzymes, the hps and phi genes from a methylotrophic bacterium, Methylomonas aminofaciens 77a, were introduced into B. cepacia TM1. The transformant strain constitutively expressed the genes for HPS and PHI, and these activities were two- or threefold higher than the activities in the wild strain. Incorporation of [14C]formaldehyde into the cell constituents was increased by overexpression of the genes. Furthermore, the degradation of vanillic acid and the growth yield were significantly improved at a high concentration of vanillic acid (60 mM) in the transformant strain. These results suggest that HPS and PHI play significant roles in the detoxification and assimilation of formaldehyde. This is the first report that enhancement of the HPS/PHI pathway could improve the degradation of vanillic acid in nonmethylotrophic bacteria.
Low Complexity X-EMS Algorithms for Nonbinary LDPC Codes (2011)

The extended min-sum (EMS) algorithm is redescribed as a reduced-search trellis algorithm (called M-EMS algorithm). Two variants of the M-EMS algorithm, called T-EMS algorithm and D-EMS algorithm, are presented. Simulation results show that, these three algorithms (referred to as X-EMS algorithms for convenience), combined with factor correction techniques, perform almost as well as the Q-ary sum-product algorithm (QSPA) but with a much lower complexity.
Structure and Composition of Pulmonary Arteries, Capillaries, and Veins (2012)

The pulmonary vasculature comprises three anatomic compartments connected in series: the arterial tree, an extensive capillary bed, and the venular tree. Although, in general, this vasculature is thin-walled, structure is nonetheless complex. Contributions to structure (and thus potentially to function) from cells other than endothelial and smooth muscle cells as well as those from the extracellular matrix should be considered. This review is multifaceted, bringing together information regarding (i) classification of pulmonary vessels, (ii) branching geometry in the pulmonary vascular tree, (iii) a quantitative view of structure based on morphometry of the vascular wall, (iv) the relationship of nerves, a variety of interstitial cells, matrix proteins, and striated myocytes to smooth muscle and endothelium in the vascular wall, (v) heterogeneity within cell populations and between vascular compartments, (vi) homo- and heterotypic cell-cell junctional complexes, and (vii) the relation of the pulmonary vasculature to that of airways. These issues for pulmonary vascular structure are compared, when data is available, across species from human to mouse and shrew. Data from studies utilizing vascular casting, light and electron microscopy, as well as models developed from those data, are discussed. Finally, the need for rigorous quantitative approaches to study of vascular structure in lung is highlighted.
Enantioselectivity of Haloalkane Dehalogenases and its Modulation by Surface Loop Engineering (2010)

In the loop: Engineering of the surface loop in haloalkane dehalogenases affects their enantiodiscrimination behavior. The temperature dependence of the enantioselectivity (lnE versus 1/T) of β-bromoalkanes by haloalkane dehalogenases is reversed (red data points) by deletion of the surface loop; the selectivity switches back when an additional single-point mutation is made. This behavior is not observed for α-bromoesters. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A WEIGHTED SUPPORT VECTOR MACHINE FOR DATA CLASSIFICATION (2007)

This paper presents a weighted support vector machine (WSVM) to improve the outlier sensitivity problem of standard support vector machine (SVM) for two-class data classification. The basic idea is to assign different weights to different data points such that the WSVM training algorithm learns the decision surface according to the relative importance of data points in the training data set. The weights used in WSVM are generated by a robust fuzzy clustering algorithm, kernel-based possibilistic c-means (KPCM) algorithm, whose partition generates relative high values for important data points but low values for outliers. Experimental results indicate that the proposed method reduces the effect of outliers and yields higher classification rate than standard SVM does when outliers exist in the training data set.
Development of an Experimentally-Validated Compact Model of a Server Rack (2007)

A simplified computational fluid dynamics and heat transfer (CFD-HT) model of an electronics enclosure was developed. The compact model was based on a server simulator, which dissipates a variable amount of heat at an adjustable air flow rate. Even though a server simulator does not accurately represent the geometry of an actual electronics enclosure, the modeling of such a unit deals with many of the same issues as the modeling of actual enclosures. Even at the server simulator level, a disparity in length scales prevents detailed modeling of intricate components most notably grilles, fins, and fans. Therefore, a compact model for each of these components was developed. Fan performance curves were determined experimentally for varying fan rotational speeds. In addition, component pressure drop characteristics were found experimentally for grilles and fin banks, and these empirical relationships were applied to the model as well. To determine the validity of the simplifications employed in the model, experimental outlet temperature and velocity measurements were taken to compare to those provided by the CFD-HT simulations.
Isolation and characterization of nutrients and value-added products from snow crab (Chionoecetes opilio) and shrimp (Pandalus borealis) processing discards (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation and characterization of nutrients and value-added products from snow crab (Chionoecetes opilio) and shrimp (Pandalus borealis) processing discardsFereidoon Shahidi and Jozef SynowieckiCite this: J. Agric. Food Chem. 1991, 39, 8, 1527–1532Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://pubs.acs.org/doi/10.1021/jf00008a032https://doi.org/10.1021/jf00008a032research-articleACS PublicationsRequest reuse permissionsArticle Views2268Altmetric-Citations360LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts