gebhart/patrepeval huggingface dataset:
<scp>CXCR</scp>7 mediates <scp>SDF</scp>1‐induced melanocyte migration (2012)

Melanoblasts are derived from the neural crest and migrate to the dermal/epidermal border of skin and hair bulges. Although melanoblast migration during embryogenesis has been well investigated, there are only a few reports regarding the migration of mature melanocytes. Here, we demonstrate that a chemokine, stromal-derived factor-1 (SDF1, also known as CXCL12), and one of its receptor CXCR7 regulate normal human epidermal melanocyte (NHEM) migration. We found that SDF1 induces the directional migration of NHEMs. Interestingly, although both CXCR4 and CXCR7 are expressed in NHEMs, blockade of CXCR4 using a CXCR4-specific neutralizing antibody did not exert any influence on the SDF1-induced migration of NHEMs, whereas blockade of CXCR7 using a CXCR7-specific neutralizing antibody did influence migration. Furthermore, SDF1-induced NHEMs migration exhibited the early hallmark events of CXCR7 signaling associated with MAP kinase activation. It is known that the phosphorylation of ERK through CXCR7 signaling is mediated by β-arrestins. The treatment of NHEMs with SDF1 resulted in the phosphorylation of ERK in a β-arrestin 2-dependent manner. These results suggest that melanocytes may have a unique mechanism of migration via SDF1/CXCR7 signaling that is different from that of other cell types.
AC plasma display device technology overview (1979)

AC Plasma display panel technology has reached maturity as evidenced by its manufacture for over five years and by several companies. The technology choices that one has in the fabrication of matrix-addressed panels operated with memory, are numerous. The effect on yield and reliability of some of the materials and processing options are discussed.
A New Synthesis of p-Methylaminobenzoyl-L-glutamic Acid<sup>1</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Synthesis of p-Methylaminobenzoyl-L-glutamic Acid1S.-C. J. Fu, Marion Reiner, and Ti Li LooCite this: J. Org. Chem. 1965, 30, 4, 1277–1278Publication Date (Print):April 1, 1965Publication History Published online1 May 2002Published inissue 1 April 1965https://pubs.acs.org/doi/10.1021/jo01015a527https://doi.org/10.1021/jo01015a527research-articleACS PublicationsRequest reuse permissionsArticle Views119Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<i>Fgf-9</i> is required for angiogenesis and osteogenesis in long bone repair (2010)

Bone healing requires a complex interaction of growth factors that establishes an environment for efficient bone regeneration. Among these, FGFs have been considered important for intrinsic bone-healing capacity. In this study, we analyzed the role of Fgf-9 in long bone repair. One-millimeter unicortical defects were created in tibias of Fgf-9(+/-) and wild-type mice. Histomorphometry revealed that half-dose gene of Fgf-9 markedly reduced bone regeneration as compared with wild-type. Both immunohistochemistry and RT-PCR analysis revealed markedly decreased levels of proliferating cell nuclear antigen (PCNA), Runt-related transcription factor 2 (Runx2), osteocalcin, Vega-a, and platelet endothelial cell adhesion molecule 1 (PECAM-1) in Fgf-9(+/-) defects. muCT angiography indicated dramatic impairment of neovascularization in Fgf-9(+/-) mice as compared with controls. Treatment with FGF-9 protein promoted angiogenesis and successfully rescued the healing capacity of Fgf-9(+/-) mice. Importantly, although other pro-osteogenic factors [Fgf-2, Fgf-18, and bone morphogenic protein 2 (Bmp-2)] still were present in Fgf-9(+/-) mice, they could not compensate for the haploinsufficiency of the Fgf-9 gene. Therefore, endogenous Fgf-9 seems to play an important role in long bone repair. Taken together our data suggest a unique role for Fgf-9 in bone healing, presumably by initiating angiogenesis through Vegf-a. Moreover, this study further supports the embryonic phenotype previously observed in the developing limb, thus promoting the concept that healing processes in adult organisms may recapitulate embryonic skeletal development.
Virtual network embedding and reconfiguration in elastic optical networks (2014)

Recent innovations in Network Virtualization and Elastic Optical Networks (EONs) enable flexible deployment of optical networks as a service. However, one open challenge is how to embed Virtual Optical Network (VON) requests onto the physical substrate network to maximize the sharing of physical resources, which is the so called Virtual Network Embedding (VNE) problem. EONs are prone to the fragmentation of spectral resources during the process of routing and spectrum allocation. The fragmentation of spectral resources in the substrate fiber links may lead to the blocking of incoming virtual network requests. This degrades the utilization of the physical resources of the Infrastructure Providers and also, decreases the revenue of the Service Providers. In this paper, we propose a novel virtual network embedding algorithm called Alignment and Consecutiveness-aware Virtual Network Embedding (ACT-VNE), which takes into account the spectrum alignment and relative loss in spectrum consecutiveness when mapping virtual nodes/links onto the physical substrate nodes/links. We also propose a min-max reconfiguration scheme called Relative Consecutiveness Loss-aware and Misalignment-aware Virtual Network Reconfiguration (RCLM-VNR) that minimizes relative consecutiveness loss and maximizes alignment with adjacent links when reconfiguring the virtual network. Simulation results show that ACT-VNE and RCLM-VNR yield a lower blocking probability and a higher link utilization ratio, which leads to better utilization of the physical resources and increased revenue.
Speciation of intermediate polar material in coal-derived process solvents by liquid chromatography/Fourier transform infrared spectrometry (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpeciation of intermediate polar material in coal-derived process solvents by liquid chromatography/Fourier transform infrared spectrometryRobert S. Brown and Larry T. TaylorCite this: Anal. Chem. 1983, 55, 4, 723–730Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://doi.org/10.1021/ac00255a032RIGHTS & PERMISSIONSArticle Views50Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (822 KB) Get e-Alertsclose Get e-Alerts
The Application of X-Ray Spectrography to Refinery Control of Additive Metals in Lubricating Oils (1957)

During the past 30 years the performance and quality of petroleum lubricants have been vastly improved. These improvements have been made possible by the application of new refining techniques and the invention of hundreds of additives to change and supplement the oil's natural properties. The use of these many additives, although of great utility to the consumer, has added many problems for the manufacturer of lubricating oils, not the least of which is that of quality control analyses. Many of these additives are organo-metallic compounds that may be added to the oils in a wide range of concentrations. The simplest control test for these additives is to analyze for the metallic component. The blending of lubricating oils whether done manually or by the use of automatic proportioning equipment is considered a batch operation, and before a batch can be considered complete and can be removed from the blending vessel, it is necessary to have the control test completed. It is obvious then, that if refineries are to use their lubricating oil blending equipment at its highest efficiency, the laboratory must be able to provide quick and accurate control analyses. To accomplish this, a number of methods such as colorimetric, polarographic, flame photometric, emission spectrographic, and X-ray spectrographic were considered to replace the conventional wet chemical methods.
Equivalent circuit model for closely coupled symmetrical two-port MIMO antennas in small volume (2010)

This paper proposes an equivalent circuit model for handset electrically small symmetrical two-port MIMO antennas. In limited volume of mobile devices only exploitation of orthogonal modes of radiation can lead to low coupling and low correlation between antennas. This paper explains the principle of operation for small MIMO antennas by means of common and differential mode excitation. A circuit model is introduced, validated based on full-wave simulations of an antenna prototype and used to aid MIMO antenna design for PCS band (1850-1990 MHz).
Does line-edge roughness matter?: FEOL and BEOL perspectives (2003)

Line edge roughness (LER) has been widely perceived to be one of the roadblocks to the continuing scaling of semiconductor devices. However, little evidence has been published on the impact of LER on device performance, particularly on the performance and the reliability of advanced interconnects. In this paper, we present such evidence from both the Front-End-Of-Line (FEOL) and Back-End-Of-Line (BEOL) standpoints. In the FEOL, we employed computer simulations to estimate the effects of LER on a number of performance parameters of sub-100nm transistors based on 2-dimensional and 3-dimensional device models. LER has been shown to affect both the average value and the variance of key device performance parameters for sub-100nm transistors. In the BEOL, we investigated the impact of LER on the performance of barrier layers in dual damascene copper interconnects. To this end, we emulated LER by roughening Si surfaces with controlled patterning by self-assembled diblock copolymers and reactive ion etching. In-situ time-resolved X-ray diffraction was used to study Cu diffusion through about 5nm Ta and TaN barrier layers deposited by plasma enhanced-atomic layer deposition (PE-ALD) on both smooth and rough surfaces. The X-ray diffraction results indicated that the surface roughness does not degrade barrier performance of the ALD Cu barriers. Mechanism of the roughness effects is also discussed. Line edge roughness is, however, expected to degrade copper interconnect performance by increasing copper electrical resistivity through enhanced electron surface scattering.
Different patterns of serum interleukin 10 response to treatment with anti-tumor necrosis factor alpha antibody (infliximab) in Crohn's disease. (2003)

Administration of anti-tumor necrosis factor antibody (anti-TNF, infliximab) down-regulates T helper 1 (Th 1) cytokines production in intestinal mucosa of patients with Crohn's disease (CD). Interleukin 10 (IL-10) is thought to be involved in CD pathogenesis through regulation of the Th 1 response. The aim of this study was to determine the IL-10 response in CD patients treated with anti-TNF. Fourteen patients with active CD received 5 mg/kg of infliximab; clinical activity assessed by Crohn's Disease Activity Index (CDAI), alpha1-acid glycoprotein and serum IL-10 were determined before and after treatment, in month 0, 1 and 5. In the group with a good clinical response, IL-10 levels diminished significantly in month 1 (p<0.05) and remained decreased in month 5. The group with a lower response showed a significant increase in IL-10 levels in month 1 (p<0.05). alpha1-acid glycoprotein levels obtained before treatment were significantly elevated in the group with a good clinical response (p<0.05) and a significant decrease in month 1 was observed in this group (p<0.05). These observations suggest that a pattern of IL-10 response might be related to the clinical response to anti-TNF treatment in CD.
Jitter attenuation phase locked loop using switched capacitor controlled crystal oscillator (2003)

A jitter attenuation, narrow-bandwidth phase-locked loop (PLL) consisting of a switched-capacitor controlled crystal oscillator (SCCXO) and a countdown sequential-logic phase/frequency detector (PFD) is described. By varying the loading capacitance dynamically, the SCCXO frequency is adjusted according to the duty cycle of the control signal. The experiment results show that a PLL of less than 2-Hz loop bandwidth and input jitter rejection up to 30 unit intervals is achieved in 3000 square mils of silicon area using 3- mu m CMOS technology. The intrinsic jitter output is 0.03 UI.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Triterpene saponins of Maesa lanceolata leaves (2011)

Chemical investigation of Maesa lanceolata leaves aqueous MeOH extract has led to the isolation of eight new triterpene glycosides identified as 16-oxo-28-hydroxyolean-12-ene 3
Friedländer Approach for the Incorporation of 6-Bromoquinoline into Novel Chelating Ligands (2003)

Nitration of 3-bromobenzaldehyde followed by sodium dithionite reduction provides 5-bromo-2-aminobenzaldehyde, which undergoes the Friedländer condensation with a variety of enolizable ketones to afford bidentate and tridentate 6-bromoquinoline derivatives. These species may be dimerized with Ni(0) to form biquinolines or treated under Sonogashira conditions to afford 6-alkynyl derivatives. Examination of optical properties indicate an unusually high emission quantum yield for 6,6'-biquinolines. [structure: see text]
Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI. (1992)

The protein kinase DAI, the double-stranded RNA-activated inhibitor of translation, is an essential component of the interferon-induced cellular antiviral response. The enzyme is regulated by the binding of activator and inhibitor RNAs. We synthesized DAI in vitro and located its RNA-binding domain within the amino-terminal 171 residues. This domain contains two copies of an RNA-binding motif characterized by a high density of basic amino acids, by the presence of conserved residues, and by a probable alpha-helical structure. Deletion of either of the two motifs prevents the binding of dsRNA, but their relative positions can be exchanged, suggesting that they cooperate to interact with dsRNA. Clustered point mutations within the RNA-binding motifs and duplications of the individual motifs indicate that the first copy of the motif plays the more important role. Mutations that impair binding have similar effects on the binding of double-stranded RNAs of various lengths and of adenovirus VA RNAI, implying that discrimination between activator and inhibitory RNAs takes place subsequent to RNA binding.
Case report: response in proteinuria due to AA amyloidosis but not Felty's syndrome in a patient with rheumatoid arthritis treated with TNF-  blockade (2004)

carriers can function normally when well but any mild illness can set them back considerably.There may be a history of weakness and clumsiness in childhood, unexplained abdominal/chest pains, tachycardias, and pseudohypertrophy of the calf muscles caused by atrophic muscle fibres being replaced by fat and connective tissue [7, 8].Genetic testing easily establishes whether a patient is a carrier, but to establish genetically whether she is a manifesting carrier X-inactivation DNA studies are required to look for preferentially skewed inactivation of the normal X chromosome, hence rendering the affected DMD X chromosome the dominant one.DMD patients will often have a raised CK and EMG studies will show low-amplitude polyphasic units similar to those seen in inflammatory myopathies.Muscle biopsy shows characteristic but non-specific changes of dystrophy.Immunocytochemical studies give quantitative analysis of dystrophin.This is usually normal or near normal in carriers but significantly reduced or absent in DMD patients and, often more subtly, in manifesting carriers.Dermatomyositis can also present with very similar symptoms.Proximal muscle weakness and skin rashes are the most common features, but the presentation may also include fatigue, fevers, arthralgias, interstitial lung disease, oesophageal dysmotility, myocarditis and dysrhythmias.Investigation reveals elevated CK during the active phase of the disease and EMG showing polyphasic action potentials with short duration and low amplitude.The muscle biopsy in dermatomyositis shows chronic inflammatory cell infiltration in the perivascular as well as the perifascicular regions.Perifascicular atrophy is diagnostic of dermatomyositis.MRI of the affected muscles depends on the chronicity and activity of the disease.In acute myositis it shows non-homogeneous increased signal intensities, especially on T 2 -weighted fatsuppressed sequences.Oedema-like changes on T 2 sequences are more typical of acute active disease while replacement with fat is characteristic of chronic, inactive myositis [9] (Fig. 1).X-rays will often show subcutaneous calcification, particularly in the juvenile form of dermatomyositis.Our patient had several features of both diseases.The presence of fevers, arthralgias, subcutaneous calcification and perivascular inflammation with perifascicular atrophy on muscle biopsy in the presence of normal dystrophin staining and inconclusive X-inactivation studies lead us to conclude that our patient is a carrier for DMD who developed low-grade dermatomyositis that has responded to low-dose immunosuppression.Informed patient consent was obtained.
An ultra-low-noise tunnel junction dc SQUID (1979)

The design, fabrication, and noise properties of an ultra-low-noise tunnel junction dc SQUID (superconducting quantum interference device) are presented. The two resistively shunted Pb-alloy tunnel junctions are each 3.6 μm diam. The SQUID has an inductance L of ≈11 pH, a critical current per junction, I0 of ≈100 μA, and a resistance per shunt R of ≈2 Ω. At 2.3 K, eI0R≈kBT, and simple theory predicts that the minimum intrinsic energy sensitivity should be ≈2h. The actual minimum value of the measured high-frequency (70 kHz) flux noise at 4.2 K is φn=1.3×10−7φ0 Hz−1/2. This corresponds to an intrinsic energy sensitivity, φ2n/2L, of 3.2×10−33 J Hz−1 or 5h. Lowering the bath temperature to 1.8 K gave no improvement in performance.
Automated Brightness and Contrast Adjustment of Color Fundus Photographs for the Grading of Age-Related Macular Degeneration (2017)

This work offers the potential to be the future of assessing and grading AMD from photos for clinical research and teleimaging.
Human Effort and Machine Learnability in Computer Aided Translation (2014)

Spence Green, Sida I. Wang, Jason Chuang, Jeffrey Heer, Sebastian Schuster, Christopher D. Manning. Proceedings of the 2014 Conference on Empirical Methods in Natural Language Processing (EMNLP). 2014.
Electro-rotation in octopole micro cages (1999)

We have developed a new design for a three-dimensional (3D) micro electrode octopole, driven by rotating electric fields in the MHz range. It allows simultaneous caging and rotation of single cells or particles with a size between 5 and 30 µm. The conflict between particle caging and the induction of particle rotation has been solved by breaking the symmetry of the electrode arrangement. The octopole consists of two layers of planar electrodes processed on glass and separated by a 40 µm thick polymer spacer, which forms a flow channel. Unlike planar four-electrode devices, the 3D octopole electrode cage can trap micro objects in free suspension. In addition, we have developed a new method for the automatic detection of single particle dynamics (MOSPAD). We also give calculations for dielectric forces and torque moments and a comparison of differences to four electrodes structures.
Mutations in the Saccharomyces cerevisiae opi3 gene: effects on phospholipid methylation, growth and cross-pathway regulation of inositol synthesis. (1989)

We report the isolation of two new opi3 mutants by EMS mutagenesis, and construction of an insertion allele in vitro using the cloned gene. We have demonstrated that the opi3 mutations cause a deficiency in the two terminal phospholipid N-methyltransferase (PLMT) activities required for the de novo synthesis of PC (phosphatidylcholine). The opi3 mutants, under certain growth conditions, produce membrane virtually devoid of PC although, surprisingly, none of the mutants displays a strict auxotrophic requirement for choline. Although the opi3 mutants grow without supplements, we have shown that the atypical membrane affects the ability of the mutant strains to initiate log phase growth and to sustain viability at stationary phase. The commencement of log phase growth is enhanced by addition of choline or to a lesser extent DME (dimethylethanolamine), and retarded by addition of MME (monomethylethanolamine). The mutant cells lose viability at the stationary phase of the cell cycle in the absence of DME or choline, and are also temperature sensitive for growth at 37 degrees especially in media containing MME. These growth defects have been correlated to the presence of specific phospholipids in the membrane. The opi3 growth defects are suppressed by an unusual mutation in the phospholipid methylation pathway that perturbs the N-methyltransferase (PEMT) activity immediately preceding the reactions affected by the opi3 lesion. We believe this mutation, cho2-S, alters the substrate specificity of the PEMT. A secondary effect of opi3 mutations is disruption of the cross pathway regulation of the synthesis of the PI (phosphatidylinositol) precursor inositol. Synthesis of inositol is controlled through regulation of the INO1 gene which encodes inositol-1-phosphate synthase. This highly regulated gene is expressed constitutively in opi3 mutants. We have used the opi3 strains to demonstrate that synthesis of either PC or PD (phosphatidyldimethylethanolamine) will restore normal regulation of the INO1 gene.