gebhart/patrepeval huggingface dataset:
An opportunistic approach for coverage and capacity optimization in Self-Organizing Networks (2013)

Self-Organizing Networks (SONs) have been introduced in LTE in order to configure and optimize the network in an autonomic manner. However, in some situations the reconfiguration of the entire network is not the most cost-efficient solution. Consequently, Opportunistic Networks have been introduced as operator governed, coordinated extensions of the infrastructure that are created dynamically where and when they are needed, exploiting the radio-environment. This work proposes a solution that can enhance SON mechanisms with opportunistic features and is utilized in a coverage and capacity optimization use case, where small cells are deployed in order to extend the capacity of a macro base station (BS). Users opportunistically exploit the resources (i.e. resource blocks) of the small cells. In addition, the small cells are configured to the optimal power level in order to maximize the users' throughput without causing interference to the other users. Furthermore, apart from maximizing the users' throughput, emphasis is given on the fairness among the users and on the Quality of Service provision through a proper resource allocation. The evaluation proved that when small cells are introduced the system's throughput is increased by 15-47%.
Native Cellular Fluorescence of Neoplastic Upper Aerodigestive Mucosa (1995)

Neoplastic mucosa of the upper aerodigestive tract within an individual patient will express native cellular fluorescent properties in vivo that differ from those of normal upper aerodigestive epithelia. This may represent a noninvasive screening method for head and neck squamous cell cancers.
Mechanochromism and Mechanical‐Force‐Triggered Cross‐Linking from a Single Reactive Moiety Incorporated into Polymer Chains (2016)

Incorporation of small reactive moieties, the reactivity of which depends on externally imposed load (so-called mechanophores) into polymer chains offers access to a broad range of stress-responsive materials. Here, we report that polymers incorporating spirothiopyran (STP) manifest both green mechanochromism and load-induced addition reactions in solution and solid. Stretching a macromolecule containing colorless STP converts it into green thiomerocyanine (TMC), the mechanically activated thiolate moiety of which undergoes rapid thiol-ene click reactions with certain reactive C=C bonds to form a graft or a cross-link. The unique dual mechanochemical response of STP makes it of potentially great utility both for the design of new stress-responsive materials and for fundamental studies in polymer physics, for example, the dynamics of physical and mechanochemical remodeling of loaded materials.
High-Frequency Pulsating DC-Link Three-Phase Multilevel NPC Inverter Without Electrolytic Capacitor (2018)

In this work it is proposed a multilevel NPC configuration for a high-frequency pulsating DC-link inverter for three-phase applications. The configuration consists of two DC/DC-pulsating converters cascaded with a DC-link capacitorless three-phase three-level NPC inverter. Due to the absence of DC-link electrolytic capacitors, the proposed inverter guarantees a long lifetime and high power density. The DC/DC-pulsating converters aim to generate the high-frequency pulsating DC-link waveform profiles which have to be synchronized with the three-phase inverter PWM. Comparing to the conventional PWM, the three-phase multilevel NPC inverter presents reduced switching losses due to the fact only one leg commutes during a switching period while the other two legs keep clamped in high or low impedance. Details of control strategy and modulation are explained. Experimental results for a 2kW setup are presented to validate the theoretical approach.
VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A<sub>2</sub> (2001)

1. Vascular endothelial growth factor (VEGF) is a potent inducer of inflammation, and we have shown that this latter effect is mediated through endothelial cell (EC) PAF synthesis. Since the phospholipid remodelling pathway enzymes (CoA-independent transacylase, CoA-IT; phospholipase A2, PLA2; and lyso-PAF acetyltransferase, lyso-PAF-AT) may participate in PAF synthesis, we assessed their contribution to VEGF-induced PAF synthesis in bovine aortic EC (BAEC) and human umbilical vein EC (HUVEC). 2. VEGF enhanced BAEC and HUVEC PAF synthesis by up to 28 and 4 fold above basal levels respectively. 3. A pretreatment with a CoA-IT and lyso-PAF-AT inhibitor (Sanguinarin; 500 nM) blocked VEGF-induced PAF synthesis by 95%, a specific CoA-IT inhibitor (SKF45905; 10 - 50 microM) was without effect, confirming the crucial role of the PLA2 and lyso-PAF-AT. 4. Treatment with secreted PLA2 (sPLA2) inhibitors which have been shown to inhibit both groups IIA and V sPLA2 (SB203347; 10 microM and LY311727; 100 microM) blocked EC PAF synthesis by up to 90%, whereas selective inhibition of group IIA sPLA2 (LY311727; 1 microM) had no significant effect. 5. RT - PCR and Western blot analyses demonstrated the presence of group V sPLA2 whereas group IIA sPLA2 was undetected in EC. 6. Treatment with cytosolic and calcium-independent PLA2 inhibitors (Arachidonyl trifluoromethyl ketone, Bromoenol lactone, Methyl arachydonyl fluorophosphate, up to 50 microM) did not prevent but rather potentiated the VEGF effect on EC PAF synthesis. 7. These results provide evidence that with VEGF activation of EC cells, the group V sPLA2 provides substrate for EC PAF formation.
Control of Common Milkweed (<i>Asclepias syriaca</i>) (1981)

Control of common milkweed ( Asclepias syriaca L.) with postemergence herbicides was investigated in greenhouse and field experiments. In greenhouse experiments, amitrole (3-amino- s -triazole), dicamba (3,6-dichloro- o -anisic acid), glyphosate [ N -(phosphonomethyl)glycine], and combinations of amitrole + dicamba, dicamba + 2,4-D [(2,4-dichlorophenoxy) acetic acid], glyphosate + 2,4-D, and glyphosate + dicamba reduced regrowth of 6-week-old common milkweed as compared with the untreated check. Postemergence herbicides commonly used in corn ( Zea mays L.), sorghum [ Sorghum bicolor (L.) Moench], and soybeans [ Glycine max (L.) Merr.] had little effect on emerged common milkweed. Removal of common milkweed top-growth as early as 1 day after treatment did not effect subsequent growth reduction from glyphosate at 0.3 kg/ha or higher. In the field, satisfactory control (70% or better) of common milkweed was obtained with glyphosate at 2.2 kg/ha applied at the early or late bud growth stage. Plots plowed 1 day after application of glyphosate at 2.2 kg/ha still retained satisfactory control of common milkweed 1 yr after treatment. Herbicides applied with a herbicide glove or a roller applicator resulted in common milkweed control similar to that obtained from broadcast spray applications.
Europium as an inhibitor of Amyloid‐β(1‐42) induced membrane permeation (2015)

Soluble Amyloid-beta (Aβ) oligomers are a source of cytotoxicity in Alzheimer's disease (AD). The toxicity of Aβ oligomers may arise from their ability to interact with and disrupt cellular membranes mediated by GM1 ganglioside receptors within these membranes. Therefore, inhibition of Aβ-membrane interactions could provide a means of preventing the toxicity associated with Aβ. Here, using Surface Plasmon field-enhanced Fluorescence Spectroscopy, we determine that the lanthanide, Europium III chloride (Eu(3+)), strongly binds to GM1 ganglioside-containing membranes and prevents the interaction with Aβ42 leading to a loss of the peptides ability to cause membrane permeation. Here we discuss the molecular mechanism by which Eu(3+) inhibits Aβ42-membrane interactions and this may lead to protection of membrane integrity against Aβ42 induced toxicity.
Reversible optical control of transmittance in polymer/liquid crystal composite films by photoinduced phase transition (1999)

We have demonstrated reversible change in transmittance of composite films, which are composed of an isotropic (I) polymer matrix and a host nematic (N) liquid crystal (LC) containing donor–acceptor type azobenzene LCs (AzoLCs) as photoresponsive molecules, by means of reversible phase transition in the LC domain. The composite films were prepared by in situ thermal polymerization-induced phase separation (PIPS) method from their homogeneous mixtures. Photoisomerization of AzoLCs was induced within the polymer network, and the resultant effect brought about isothermal change in transmittance. The photoinduced reversible and repeatable changes between opaque light scattering and clear transparent states were achieved effectively by irradiation with a monochromatic light at 366 nm. These changes are attributed to photochemical N–I phase transition and rapid thermal I–N phase transition in the host LC domain based on reversible change in molecular sharp of the guest AzoLCs. The optical effects were influenced by such factors as temperature of the composite films in the initial state and photoisomerization ability of the guest AzoLCs. The composite films acted as an optical switching material without polarizers.
Current status of HTRF<sup>®</sup>technology in kinase assays (2008)

HTRF kinase assays are homogeneous, robust, sensitive, easy to miniaturize and high-throughput. This assay format is versatile, as both peptide and protein substrates can be used, and high ATP concentrations are tolerated, which enables the assay to be performed under conditions mimicking the physiological environment. HTRF kinase assays have been applied to both high-throughput screening and compound mechanistic studies. Besides protein kinases, the technology has now been expanded into the lipid kinase family. Furthermore, the utility of HTRF technology in cellular assays is emerging. HTRF kinase assays are a great addition to the toolbox for kinase drug discovery.
Rare Earth Azatrane Chemistry:  Facile Cleavage of THF To Give a Y<sub>2</sub>Li<sub>3</sub>O Cluster (1996)

Azatrane complexes with the [N(CH2CH2NSiMe3)]3- ligand are known for main group, transition, and actinide metals but, until now, not for the rare earths. Here we report the reaction of Li3[N(CH2CH2NSiMe3)3] with YCl3 to give a remarkable Y2Li3 cluster containing not only a [N(CH2CH2NSiMe3)3]3- ligand but also fragments arising from a facile cleavage of THF solvent.
Inside Back Cover: Recognition of Nucleic Acid Junctions Using Triptycene‐Based Molecules (Angew. Chem. Int. Ed. 50/2014) (2014)

Rationally designed nucleic acid junction binders based on a triptycene scaffold were found to significantly stabilize DNA and RNA three-way junctions. In their Communication on page 13746 ff., D. M. Chenoweth and S. A. Barros report that the scaffold provides a new architecture for the development of junction binders with enhanced recognition properties. Initial cytotoxicity data in two human ovarian carcinoma cell lines are promising.
Evolutionary Conservation of Vertebrate Blood–Brain Barrier Chemoprotective Mechanisms in<i>Drosophila</i> (2009)

Pharmacologic remedy of many brain diseases is difficult because of the powerful drug exclusion properties of the blood-brain barrier (BBB). Chemical isolation of the vertebrate brain is achieved through the highly integrated, anatomically compact and functionally overlapping chemical isolation processes of the BBB. These include functions that need to be coordinated between tight diffusion junctions and unidirectionally acting xenobiotic transporters. Understanding of many of these processes has been hampered, because they are not well mimicked by ex vivo models of the BBB and have been experimentally difficult and expensive to disentangle in intact rodent models. Here we show that the Drosophila melanogaster (Dm) humoral/CNS barrier conserves the xenobiotic exclusion properties found in the vertebrate vascular endothelium. We characterize a fly ATP binding cassette (ABC) transporter, Mdr65, that functions similarly to mammalian xenobiotic BBB transporters and show that varying its levels solely in the Dm BBB changes the inherent sensitivity of the barrier to cytotoxic pharmaceuticals. Furthermore, we demonstrate orthologous function between Mdr65 and vertebrate ABC transporters by rescuing chemical protection of the Dm brain with human MDR1/Pgp. These data indicate that the ancient origins of CNS chemoprotection extend to both conserved molecular means and functionally analogous anatomic spaces that together promote CNS selective drug partition. Thus, Dm presents an experimentally tractable system for analyzing physiological properties of the BBB in an intact organism.
Zone-level occupancy counting with existing infrastructure (2012)

Through accurate and dynamic occupancy detection, building actuation systems can fine tune the targets of their actions to better fit the patterns of usage in modern buildings. We outline a method for achieving this through existing wireless infrastructure and present a demonstration of its viability in a corporate environment.
Parallel File System-surpported Server Virtual Environment in Data Center (2010)

Server virtualization is the key technology for data center. It can be used to integrate servers, reduce hardware cost, reduce space and power consumption in data center. Dynamic migration is an important feature of server virtualization technology that makes it possible for a virtual server to migrate from one PC to another at run-time. By using dynamic migration, service interruptions caused by PC servers’ hardware maintenance in plan can be avoided. At present, in most server virtualization products, dynamic migration requires shared storage. As the number of virtual servers increases, the performance of shared storage becomes the bottleneck of the virtual disks’ performance. Therefore, it is of great significance to build a unified namespace parallel file system as the shared storage for server virtualization. In this paper, the Large-scale deployment of KVM-based server virtualization and the implementation of using parallel file system in server virtualization are discussed.
Antileukemic effect of a synthetic vitamin D3 analog, HY-11, with low potential to cause hypercalcemia (2008)

1alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3] is capable of inhibiting the proliferation of acute myelogenous leukemia (AML). However, toxicity of hypercalcemia has limited the use of 1,25(OH)2D3 in clinical trials. We have evaluated 11 synthesized vitamin D3 analogs for their ability to inhibit clonal growth of HL-60 myeloid leukemic cells. Among the 11 vitamin D3 analogs, HY-11 (code name) showed the most potent antileukemic activity with 2.5x10(-6) M of IC50, however, it did not affect the cellular growth of normal peripheral blood mononuclear cells until 10(-6) M. Flow cytometric analysis indicated that HY-11 induced the G1 arrest in a dose-dependent manner, which was mediated via inactivation of CDK4 and CDK6 in association with up-regulation of CDKI (cyclin-dependent kinase inhibitor), p27 and Rb protein. Induction of apoptosis was mediated via caspase-3 pathway in HY-11-treated HL-60. In addition, HY-11 enhanced the expression of TGF-beta1, TGF-beta receptor type I and II and vitamin D3 receptor (VDR). VDR expression was increased by TGF-beta1, suggesting that TGF-beta1 might be involved in the antiproliferative effect of HY-11 on HL-60 cells by autocrine and paracrine regulation. Serum calcium levels were within normal limit when HY-11 was given intraperitoneally (i.p.) every other day for 5 weeks to BALB/c mice at the doses of 10(-7), 10(-6)and 10(-5) M. HY-11 inhibited the growth of WEHI-3BD+ mouse leukemic cells in vitro, and syngeneic BALB/c mice that received WEHI-3BD+ mouse leukemic cells and HY-11 had a significantly longer survival without producing hypercalcemia compared to control group. In summary, HY-11 is a vitamin D3 analog that inhibited the proliferation of human AML cell line, HL-60, through induction of cell cycle arrest, triggering apoptosis as well as modulation of TGF-beta1 and its receptors. In particular, HY-11 significantly increased the survival of mice that had myeloid leukemia without producing hypercalcemia.
Psychologic Aspects of Acne (1991)

Psychologic factors may play a significant role in acne in at least three ways. First, as many patients readily report, emotional stress can exacerbate acne. Second, it is common for patients to develop psychiatric problems as a consequence of the conditions, such as those related to low self-esteem, social phobias, or depression. Finally, primary psychiatric illnesses such as obsessive-compulsive disorder and psychosis may be based on a complaint that is focused on acne. In this review we hope to facilitate an understanding of how emotional factors and acne connect, and aid the dermatologist in identifying the possible presence of psychiatric problems stemming from or contributing to the disorder.
<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data (2009)

The package is freely available under the LGPL licence from the Bioconductor web site (http://bioconductor.org).
A decision‐support system for scheduling in a customer‐oriented manufacturing environment (1996)

An intelligent decision‐support system was designed for assessing schedulability prior to assigning parts for scheduling. This was designed as part of a larger system for intelligent, real‐time control of a manufacturing system operation, where one of the system objectives was just‐in‐time delivery of production output. The manufacturing system was a conventional cellular manufacturing system where machines were assumed occasionally to fail. All necessary requirements for the processing of a job should actually or anticipatively be satisfied before a job is scheduled. The decision‐support system attempts to satisfy these requirements. The system thus helps the decision maker to make the right decision when system and customer constraints are violated. Illustrates the operation of the system through an example.
Clinical Versus Urodynamic Diagnosis in an Incontinent Geriatric Female Population (1987)

The clinical presentation of incontinence was compared to diagnoses based on urological and urodynamic evaluation in 135 elderly women assessed consecutively in an outpatient clinic. Most patients (64 per cent) presented with mixed symptoms: 16 per cent presented with pure stress and 16 per cent with pure urge incontinence. After evaluation 46 per cent of the patients had stress incontinence with a stable bladder, 27 per cent had detrusor instability or hyperreflexia without sphincter weakness and 19 per cent had mixed urodynamic abnormalities. Presenting symptoms were predictive of urodynamic diagnosis in 64 per cent of the patients with pure stress incontinence and 55 per cent with pure urge incontinence. In general, symptoms in our patient population were less predictive of urodynamic findings than in previously reported series of younger incontinent women but they were more predictive than in other series of elderly women. Predictive values for some urodynamic findings were enhanced by combining a symptom with certain physical findings. Implications of these data for the evaluation and treatment of incontinence in the geriatric population are discussed.
<title>Power control algorithms in wireless communications</title> (2002)

This paper presents a comprehensive review of the published algorithms on power control for cellular systems. The majority of the research is focused on Code Division Multiple Access (CDMA) systems, although a small fraction of the reviewed literature pertains to Frequency Division Multiple Access (FDMA) and Time Division Multiple Access (TDMA).
Fiber-Based 589 nm Laser for Sodium Guide Star (2006)

This report results from a contract tasking University of Southampton as follows: The work will entail the construction of the required sub-assemblies, their integration into the laser source, and the exploration and adjustment of parameters in order to obtain adequate performance. We have reasonable versions of several of the needed fibers, and though we are likely to have to fabricate new fiber, this requirement is assumed to be modest. The 1060 nm pulsed diode-based seed source is based on our previous work in the field. A simple low-power pre-amplifier (YDFA) with high gain efficiency will be built with all-fiber technology and core-pumping. The 1178 nm Raman fiber seed source requires appropriate highly nonlinear fiber to be acquired or fabricated and, more challenging, narrow-linewidth FBGs to be written. A cladding-pumped Yb-doped fiber laser with a few watts of output power will be assembled, to be used as a pump source for the Raman seed source. Fiber for the high-power amplifier and Raman converter will be fabricated as necessary. We hope to be able to use modest-size, strictly single-mode cores, as this will simplify system integration (splicing in particular). We plan to use a pre-configured frequency-doubler which requires minimum effort on our part. Besides fabrication and assembly of the source, most effort will go into characterization and evaluation of components, sub-assemblies, and the system as a whole. This is important to identify the right operating point, which is relatively narrow in a pulsed system based on nonlinear conversion. It will also enable us to assess the power-scaling potential and overall potential of the approach.
Scatter correction techniques in 3D PET: a Monte Carlo evaluation (1999)

In this work, a Monte Carlo software package, PET-EGS, designed to simulate realistic PET clinical studies, was used to assess three different approaches to scatter correction in 3D PET: analytical (gaussian fitting technique), experimental (dual energy window technique) and probabilistic (Monte Carlo technique). Phantom and clinical studies were carried out by 3D PET and simulated by PET-EGS. A clinical study (/sup 18/F-FDG brain study) was simulated assuming PET emission/transmission multiple-volume images as a voxelised source object describing the distribution of both the radioactivity and attenuation coefficients and accounting for out-of-field activity and media. The accuracy of PET-EGS in modelling the physical response of a 3D PET scanner was assessed by statistical comparison between measured and total (scatter+unscatter) simulated distributions (probability for the two distributions to be the same distribution: p>0.95). The accuracy of the scatter models, for each scatter correction technique, was evaluated on sinograms by statistical comparison between the estimated and the simulated scatter distributions (agreement <1 /spl sigma/). The accuracy of scatter correction was evaluated on sinograms by comparison between scatter corrected and simulated unscatter distributions, proving a comparable accuracy of all the considered scatter correction techniques for brainlike distributed sources.