gebhart/patrepeval huggingface dataset:
Synthetic Oxygen Carriers in Cardiac Tissue Engineering (2007)

The prominence of cardiovascular diseases has prompted investigations into alternative treatment options, including tissue engineering. Currently, the biggest limitation in cardiac tissue engineering lies in delivering oxygen to all cells within the construct. Synthetic oxygen carriers hold much promise in that they have high affinity for oxygen and can be supplemented to culture medium without adverse effect on the cells. This review highlights two complementary studies by our group that utilized oxygen carriers in cardiac tissue engineering. Experimental and modeling studies were performed to evaluate the effect of a perfluorocarbon (PFC)-based synthetic oxygen carrier, Oxygent, on oxygen supply within tissue engineered cardiac constructs. Porous biorubber scaffolds with an array of parallel channels mimicking the capillary network were seeded with cardiomyocytes and fibroblasts, and cultivated in medium supplemented with PFC. The presence of PFC enhanced the transport of oxygen, increased oxygen concentrations, and yielded constructs that displayed stronger cardiac-like phenotype.
klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis (2016)

The heartbeat and blood flow signal to endocardial cell progenitors through mechanosensitive proteins that modulate the genetic program controlling heart valve morphogenesis. To date, the mechanism by which mechanical forces coordinate tissue morphogenesis is poorly understood. Here we use high-resolution imaging to uncover the coordinated cell behaviours leading to heart valve formation. We find that heart valves originate from progenitors located in the ventricle and atrium that generate the valve leaflets through a coordinated set of endocardial tissue movements. Gene profiling analyses and live imaging reveal that this reorganization is dependent on extracellular matrix proteins, in particular on the expression of fibronectin1b. We show that blood flow and klf2a, a major endocardial flow-responsive gene, control these cell behaviours and fibronectin1b synthesis. Our results uncover a unique multicellular layering process leading to leaflet formation and demonstrate that endocardial mechanotransduction and valve morphogenesis are coupled via cellular rearrangements mediated by fibronectin synthesis.
Allostasis and the human brain: Integrating models of stress from the social and life sciences. (2010)

We draw on the theory of allostasis to develop an integrative model of the current stress process that highlights the brain as a dynamically adapting interface between the changing environment and the biological self. We review evidence that the core emotional regions of the brain constitute the primary mediator of the well-established association between stress and health, as well as the neural focus of wear and tear due to ongoing adaptation. This mediation, in turn, allows us to model the interplay over time between context, current stressor exposure, internal regulation of bodily processes, and health outcomes. We illustrate how this approach facilitates the integration of current findings in human neuroscience and genetics with key constructs from stress models from the social and life sciences, with implications for future research and the design of interventions targeting individuals at risk.
Effect of Freezing Parameters (Freeze Cycle and Thaw Process) on Tissue Destruction Following Renal Cryoablation (2002)

Renal cryodestruction via laparoscopic access achieves complete tissue ablation without complications. The double freeze cycle produced significantly larger areas of LN than the single freeze regardless of the thaw process. The type of thaw process did not affect the amount of tissue damage. Utilizing a double 15-minute freeze cycle with the faster active thaw process will effectively cryoablate renal tissue as well as significantly reduce overall operative time.
Mcl-1 Regulation and Its Role in Multiple Myeloma (2004)

Among the Bcl-2 family, myeloid cell leukemia-1 (Mcl-1) distinguishes itself from the other pro-survival proteins by its ability to oppose to a wide variety of pro-apoptotic stimuli, short half-life, and presence of polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) domains (PEST). Moreover, Mcl-1 undergoes a complex transcriptional, post-transcriptional, and post-translational regulation process. This regulation modifies not only Mcl-1 expression, but also its function. Various extra-cellular stimuli, including cytokines, growth factors, 12-O-tetradecanoyl-phorbol 13-acetate (TPA) and IFN, activate pathways which regulate Mcl-1 expression. Furthermore, Mcl-1 can be alternatively spliced into a long (Mcl-1) or a short (Mcl-1S) form. Mcl-1 opposes pro-apoptotic proteins and can be either cleaved or phosphorylated at a post-translational level. Mcl-1-spliced products, Mcl-1-cleaved products, or phosphorylated Mcl-1 have either a pro or an anti-apoptotic function, highlighting the complexity and pivotal role of Mcl-1 regulation. Here we discuss the regulation and function of Mcl-1 in the pathophysiology of multiple myeloma.
Guanidinophenyl derivatives of pyrazole: synthesis and inhibitory effect on serine proteinases, blood coagulation and platelet aggregation. (1986)

Guanidinophenyl derivatives of pyrazole have been synthesized. Their inhibitory effects on (i) bovine trypsin, bovine thrombin, porcine pancreatic kallikrein catalyzed hydrolysis of p-nitro anilide of N alpha -benzoyl-arginine and (ii) blood coagulation and platelet aggregation, were investigated. The kinetic behaviour of all compounds conformed to that of a reversible competitive inhibition pattern, and they were also found to act in vitro as inhibitors of platelet aggregation induced by ADP.
Integrated microstrip-fed slot array antenna for emerging wireless application in IPD technology (2011)

In this paper, the design of a 2-by-1 array of microstrip -coupled slot antenna in Integrated Passive Device (IPD) technology is explained. This antenna which operates in the frequency range 57-64 GHz, has maximum gain 4.9 dBi. The radiation efficiency at 60 GHz is 76%. The designed antenna is integrated over an alumina substrate using flip-chip bonding technique. The size of the antenna is 2 mm × 4.5 mm and can be used for antenna in package for mm-wave wireless systems.
Practical Guide to Infrared Microspectroscopy (1995)

Minimizing optical nonlinearities in infrared microspectroscopy uniting microscopy and spectroscopy infrared microimaging application of reflectance microspectroscopy in the electronics industry depth profiling and defect analysis of films and laminates - an industrial approach infrared microspectroscopy of forensic paint evidence forensic examination of textile fibers by infrared microspectroscopy infrared microspectroscopy analysis of cultural artifacts pharmaceutical applications of infrared microspectroscopy infrared microspectroscopy in the geosciences with emphasis on long wavelengths and high pressures unique preparation techniques for nanogram samples sample preparation techniques for microsamples.
Stromal cells in long-term murine bone marrow culture: FACS studies and origin of stromal cells in radiation chimeras. (1986)

Adherent layers from hematopoietically active long-term bone marrow cultures (LTBMC), incubated with fluorescent beads, were analyzed for autofluorescence and phagocytic ability, using a fluorescence-activated cell sorter (FACS). Four groups of cells were separated from the adherent layers, including a group of large polygonal fibroblastoid stromal cells. Long-term chimeras were made by lethal irradiation of CBA/Ca (CBA) and C57Bl6/J (B6) mice and repopulation with phosphoglycerate kinase (PGK-1) alloenzyme-congenic bone marrow cells. Hematopoietically active LTBMC were established from such chimeras, and donor and host contributions of FACS-sorted adherent-layer cells were measured. While macrophages and other hematopoietic cells were of donor origin, the fibroblastoid stromal cells were mainly or entirely host derived.
The scaled unscented transformation (2002)

This paper describes a generalisation of the unscented transformation (UT) which allows sigma points to be scaled to an arbitrary dimension. The UT is a method for predicting means and covariances in nonlinear systems. A set of samples are deterministically chosen which match the mean and covariance of a (not necessarily Gaussian-distributed) probability distribution. These samples can be scaled by an arbitrary constant. The method guarantees that the mean and covariance second order accuracy in mean and covariance, giving the same performance as a second order truncated filter but without the need to calculate any Jacobians or Hessians. The impacts of scaling issues are illustrated by considering conversions from polar to Cartesian coordinates with large angular uncertainties.
Radiofrequency-Triggered Pacemakers: Uses and Limitations (1978)

Seven patients with either recurrent paroxysmal supraventricular tachycardia (five), alternating bradycardiatachycardia (one), or ventricular tachycardia (one) underwent insertion of permanent radiofrequency-triggered pacemakers. Follow-up evaluation (36 ± 24 months, mean ± SD) revealed that arrhythmias were well controlled in five of seven patients, although three of the five required medication to decrease frequency of arrhythmias. Overdrive pacing was ineffective in one patient with Wolff-Parkinson-White syndrome who had recurrent bouts of atrial fibrillation or atrial flutter. One additional patient with ventricular tachycardia became refractory to overdrive atrial pacing. These studies document the long-term effectiveness of radiofrequency pacemakers in some patients with recurrent refractory arrhythmias. Careful patient selection and electrophysiologic studies are mandatory before implantation of a permanent radiofrequency pacemaker. Physicians must be aware of both the benefits and possible limitations of radiofrequency pacemakers in order to choose between pacemaker versus surgical intervention in patients with cardiac arrhythmias refractory to standard drug therapy.
Glass transitions in ethylene copolymers and vinyl homopolymers and copolymers (1962)

Abstract In ethylene copolymers isolatedCH 2 CHRCH 2  groups undergo a glass transition at about −10 to −50°C., the exact temperature depending upon the nature of R. For any given copolymer the temperature of the transition remains reasonably constant over a broad composition range at high ethylene contents. At high comonomer content the transition rises with composition along the line drawn between the glasstransition temperature of polyethylene and that of the homopolymer of the comonomer in question. A second glass transition is also observed in ethylene copolymers at about −125°C. over the whole composition range. This transition corresponds to motion of CH 2  sequences of three to five or more in the main chain. The temperature position of this transition is usually independent of the nature of the rest of the chain. The behavior of ethylene copolymers is quite different from that of normal vinyl copolymers, where only a single glass transition is observed for each composition and where the temperature position of the transition changes uniformly with composition along the line drawn between the glass transitions of the respective homopolymers. It is concluded that the motions involved in the glass transitions of the main chain CH 2  sequences and of isolated CH 2 CHRCH 2  groups in ethylene copolymers are localized, involving only a few carbon atoms. In the case of the normal vinyl copolymers, on the other hand, the motion at the transition appears to be a long‐range motion involving a great many chain carbon atoms and cooperative motion of the pendent groups. This change in the nature of the motion involved at the glass transition in going from high ethylene content copolymers to low ethylene content or vinyl copolymers appears to arise because of steric hindrance and/or restrictive dipolar forces between the pendent groups of the CH 2 CHRCH 2  segments in those cases were they are not isolated from each other. Finally, it is concluded that all vinyl homopolymers would have glass transitions in the −10 to −50°C. range if steric hindrance between the side groups did not occur. It is shown that as the pendent group becomes less bulky or is further separated from the main chain by CH 2 groups the glass transition temperature decreases presumably towards the −10 to −50° range characteristic of the transition of isolated CH 2 CHRCH 2  groups.
A SIMD/dataflow architecture for a neurocomputer for spike-processing neural networks (NESPINN) (2002)

We present the architecture of a a neurocomputer for the simulation of spike-processing biological neural networks (NESPINN). It consists mainly of a neuron state memory, two connectivity units, a spike-event list, a sector unit and the NESPINN chip with a control unit, and eight PEs with 2 kB local on-chip memory each. In order to increase the performance features such as mixed SIMD/dataflow mode are included. The neurocomputer allows the simulation of up to 512 k neurons with a speed-up of ca. 600 over a Sparc-10. It thus allows tackling difficult low vision problems (e.g. scene segmentation) or simulation of the detailed spike behaviour of large cortical networks.
Reflection Z-scan technique for the study of nonlinear refraction and absorption of a single interface and thin film (1996)

Spatial modification of a Gaussian beam reflected from a single interface and a thin film with intensity-dependent refractive index and absorption coefficient is studied theoretically. The measurement of this modification by different positions of the nonlinear surface with respect to the beam waist (the modified Z-scan technique) can be used to study nonlinear optical properties. For a single interface the measurements permit the nonlinear parameters to be determined unambiguously. For a thin film the multiple internal reflections are important, and the value and the sign of nonlinear refraction and absorption coefficients cannot be uniquely found.
100 Gbit/s error-free retiming operation of monolithic optical gate integrating with photodiode and electroabsorption modulator (2004)

Error-free retiming operation of a monolithic PD-EAM optical gate at a data rate of 100 Gbit/s has been successfully demonstrated. A timing margin of 2.2 ps was achieved with a power penalty below 1 dB at a bit error rate of 10−9.
Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay (2006)

The exon junction complex (EJC) is deposited on mRNAs by the process of pre-mRNA splicing and is a key effector of downstream mRNA metabolism. We previously demonstrated that human eIF4AIII, which is essential for nonsense-mediated mRNA decay (NMD), constitutes at least part of the RNA-binding platform anchoring other EJC components to the spliced mRNA. To determine the regions of eIF4AIII that are functionally important for EJC formation, for binding to other EJC components, and for NMD, we now report results of an extensive mutational analysis of human eIF4AIII. Using GFP-, GST- or Flag-fusions of eIF4AIII versions containing site-specific mutations or truncations, we analyzed subcellular localizations, protein-protein interactions, and EJC formation in vivo and in vitro. We also tested whether mutant proteins could rescue NMD inhibition resulting from RNAi depletion of endogenous eIF4AIII. Motifs Ia and VI, which are conserved among the eIF4A family of RNA helicases (DEAD-box proteins), are crucial for EJC formation and NMD, as is one eIF4AIII-specific region. An additional eIF4AIII-specific motif forms part of the binding site for MLN51, another EJC core component. Mutations in the canonical Walker A and B motifs that eliminate RNA-dependent ATP hydrolysis by eIF4AIII in vitro are of no detectable consequence for EJC formation and NMD activation. Implications of these findings are discussed in the context of other recent results and a new structural model for human eIF4AIII based on the known crystal structure of Saccharomyces cerevisiae eIF4AI.
RELATIVE POSE ESTIMATION FROM AIRBORNE IMAGE SEQUENCES (2012)

Abstract. We present a new relative pose estimation method for applications based on airborne image sequences. The performance of the method is tested using simulated test data, with correct and erroneous original conditions, as well as using real data. The calculated results obtained from real images are compared to the on-board measured angles. The results show that the proposed method is very precise and fast. Most matching algorithms are very computation time expensive mainly because they rely on RANSAC methods that need a lot of matching points. Due to the circumstance that only two corresponding points are necessary to solve the equation system, our technique doesn't need much computation time. Outliers are detected by a special back-matching technique. A method based on Polynomial Homotopy Continuation (PHC) is used to solve the complex polynomial equation system. The proposed pose solver method runs without SVD calculations, expensive minimisation or optimisation. Start parameters are not necessary. Furthermore, no a priori knowledge is required, besides focal length in pixel units and overlapping consecutive images. Outcomes are three relative orientation angles and a scaling parameter between two subsequent images, as well as displacement vectors in image pixel coordinate units. In addition, the PHC pose estimation method can balance small pixel errors. All these properties indicate the high applicability of the proposed method.
Inverse tone mapping (2006)

In recent years many Tone Mapping Operators (TMOs) have been presented in order to display High Dynamic Range Images (HDRI) on typical display devices. TMOs compress the luminance range while trying to maintain contrast. The dual of tone mapping, inverse tone mapping, expands a Low Dynamic Range Image (LDRI) into a HDRI. HDRIs contain a broader range of physical values that can be perceived by the human visual system. The majority of today's media is stored in low dynamic range. Inverse Tone Mapping Operators (iTMOs) could thus potentially revive all of this content for use in high dynamic range display and image-based lighting. We propose an approximate solution to this problem that uses median-cut to find the areas considered of high luminance and subsequently apply a density estimation to generate an Expand-map in order to extend the range in the high luminance areas using an inverse Photographic Tone Reproduction operator.
High Temperature Ultra Stable Close-Coupled Catalysts (1995)

<div class="htmlview paragraph">Close-coupled catalysts are being actively pursued by automotive engineers in order to meet stringent LEV/ULEV emission standards. However, future applications of close coupled catalyst will be exposed to 50 to 100°C higher operating temperatures with elimination of fuel enrichment to cool the catalyst. A successful close coupled catalyst technology must then be resistant to even higher temperature deactivation and yet continue to function at low temperature during the vehicle cold start. A close coupled catalyst technology is formulated through advanced catalyst design to meet LEV and ULEV emission standards after high temperature aging at 1050°C. This paper will show the inherent stability of the close coupled catalyst for both light-off temperature and steady state performance for aging temperatures up to 1100°C. In vehicle evaluation, experimental results on the effect of close coupled catalyst volume, precious metal loading and aging temperature on HC emissions during cold start and FTP will be presented. Results show that this close coupled catalyst technology achieves LEV/ULEV HC emissions after high temperature aging.</div>
Heat conductivity of the heavy-fermion compound YbAgCu4 (2001)

The heat conductivity and electrical resistivity of a polycrystalline YbAgCu4 sample were measured in the 4.2–300-K temperature range. It is shown that at low temperatures (in the region corresponding to the coherent Kondo lattice) the Lorenz number behaves in accordance with a theoretical model developed for heavy-fermion materials.
A Bottleneck Eliminating Approximate Algorithm for PON Layout (2007)

To layout a passive optical network (PON) under the constraints of cost effectiveness is essentially a constraint optimization problem. In this paper, we first show that in general this problem is hard not solvable in polynomial time. We then follow it up by exploiting certain graph theoretical techniques and proposing an algorithm that produces an effective layout for PONs. We verify our results via an experimental methodology, where our proposed approach performs extremely well compared to randomized layouts
Incorporation of Unnatural Pyrimidine Bases into Deoxyribonucleic Acid of Mammalian Cells (1959)

When a mammalian cell strain was incubated with 5-iododeoxyuridine and 5-bromodeoxyuridine, DNA thymine was partially replaced by the halogen-containing pyrimidines. The extent of incorporation of the unnatural bases increased when amethopterin and hypoxanthine were added to the medium. It is thus evident that the replacement of DNA thymine by selected structural analogs, a phenomenon previously reported for bacterial systems, is applicable to cells of higher organisms.
rf oxygen plasma assisted molecular beam epitaxy growth of BiFeO3 thin films on SrTiO3 (001) (2007)

Bi Fe O 3 (BFO) thin films were grown epitaxially by rf oxygen plasma assisted molecular beam epitaxy on SrTiO3 (001) substrates with and without SrRuO3 (SRO) thin film electrodes. BFO thin films show excellent crystalline quality and x-ray diffraction studies show the presence of only one phase. Polarized Raman spectroscopy also confirmed high crystalline quality of the films. BFO thin films show presence of ferroelectricity on conducting Nb:STO substrates and SRO-STO. Films on Nb:STO have leakage currents ∼0.1μA∕cm2 and remnant polarization ∼28μC∕cm2. Films on SRO-STO have leakage currents ∼8nA∕cm2 and remnant polarization ∼56μC∕cm2. Nb diffusion and poor surface quality of Nb:STO can be attributed to the difference in ferroelectric and leakage properties of the BFO thin films grown on Nb:STO and SRO-STO.
Secure Distributed Computing on Untrusted Fog Infrastructures Using Trusted Linux Containers (2018)

Fog and Edge computing provide a large pool of resources at the edge of the network that may be used for distributed computing. Fog infrastructure heterogeneity also results in complex configuration of distributed applications on computing nodes. Linux containers are a mainstream technique allowing to run packaged applications and micro services. However, running applications on remote hosts owned by third parties is challenging because of untrusted operating systems and hardware maintained by third parties. To meet such challenges, we may leverage trusted execution mechanisms. In this work, we propose a model for distributed computing on Fog infrastructures using Linux containers secured by Intel's Software Guard Extensions (SGX) technology. We implement our model on a Docker and OpenSGX platform. The result is a secure and flexible approach for distributed computing on Fog infrastructures.