gebhart/patrepeval huggingface dataset:
Effects of High Pressure Treatments on Polymeric Films for Flexible Food Packaging (2014)

Effects of high pressure (HP) treatments on functional and morphological properties of commercial packaging films have been investigated, to assess their suitability for use in these processes. Experimental analyses have been performed on packaging films, used to make pouches containing four different types of food simulants, after HP pasteurization and sterilization treatments at 200, 500 and 700 MPa. The investigated polymeric flexible packaging structures were single layer as well as bilayer films. Effects of treatments on structural/morphological properties (i.e. crystallinity and density) and on thermodynamic and barrier properties were addressed. Quite all the investigated films were found to be suitable for HP pasteurization, which only determined a negligible effect on the glass transition temperatures and on density of the amorphous regions of some polymeric materials, without a significant effect on functional properties of the packaging. Only bilayer structures including metalized polyethyleneterephthalate were not able to withstand processing conditions because of an extensive delamination accompanied by loss of metallization layer. Conversely, in the case of HP sterilization, combined effects of HP and relatively high temperature caused significant modifications in some of the packaging materials, even those not including a metalized film. In particular, localized delamination occurred in the case of bilayer structures made by laminating polyethyleneterephtalate with linear low density polyethylene or with polypropylene. Films obtained by laminating cast polyamide and bioriented polyamide with polypropylene displayed no evidence of delamination. In the case of films not displaying delamination, only limited changes in gas and vapour barrier properties were detected. Copyright © 2014 John Wiley & Sons, Ltd.
Thermal management of high power memory module (2006)

In the semiconductor industry, the memory device has not been considered as a high power consuming product. However, the increase in the market requirements for high speed and high density has resulted in memory devices that consume more power. Especially, a memory module accommodated with many high speed memory devices can reach to very high levels of power consumption, which in turn, can reach to very high junction temperatures. Therefore, the devices can not be operated properly without thermal management. Hence, in this paper, we are looking for a way to manage the heat generated in a high power memory module. To achieve this goal, a plate fin type heat sink based on air cooling was adopted with consideration of constraints related to the implementation of its thermal solutions. Then, the cooling capability of the memory module was estimated by a parametric study. The parametric study shows that a 20mm module pitch is necessary to dissipate the amount of heat that is targeted in this paper, which is 30W. With the 20mm module pitch, an optimized heat sink configuration was designed by simulation and the cooling performance of the designed heat sink was validated by experiments. For the experiment, test modules were assembled and the junction temperatures of memory devices mounted on modules was measured on a test board. The results showed that simulated and measured data well correlate with each other within acceptable ranges. The maximum cooling capability of the designed heat sink is 37.1W with a 20mm module pitch
Proactive Workload Management in Hybrid Cloud Computing (2014)

The hindrances to the adoption of public cloud computing services include service reliability, data security and privacy, regulation compliant requirements, and so on. To address those concerns, we propose a hybrid cloud computing model which users may adopt as a viable and cost-saving methodology to make the best use of public cloud services along with their privately-owned (legacy) data centers. As the core of this hybrid cloud computing model, an intelligent workload factoring service is designed for proactive workload management. It enables federation between on- and off-premise infrastructures for hosting Internet-based applications, and the intelligence lies in the explicit segregation of base workload and flash crowd workload, the two naturally different components composing the application workload. The core technology of the intelligent workload factoring service is a fast frequent data item detection algorithm, which enables factoring incoming requests not only on volume but also on data content, upon a changing application data popularity. Through analysis and extensive evaluation with real-trace driven simulations and experiments on a hybrid testbed consisting of local computing platform and Amazon Cloud service platform, we showed that the proactive workload management technology can enable reliable workload prediction in the base workload zone (with simple statistical methods), achieve resource efficiency (e.g., 78% higher server capacity than that in base workload zone) and reduce data cache/replication overhead (up to two orders of magnitude) in the flash crowd workload zone, and react fast (with an X^2 speed-up factor) to the changing application data popularity upon the arrival of load spikes.
Real-Time Network-Based Anomaly Intrusion Detection (2001)

The global internet has made computer systems world-wide vulnerable to an ever-changing array of attacks. A new approach to perform real-time network-based anomaly intrusion detection is presented in this paper. Real-time Tcptrace generates data streams which are analysed to detect network-based attacks. Real-time Tcptrace periodically reports statistics on all the open TCP/IP connections in the network. Then, using the Abnormality Factor method, statistical profiles are built for the normal behavior of the network services. Abnormal activity is then flagged as an intrusion. This approach has the advantage of being able to monitor any service without the prior knowledge of modelling its behavior. The paper presents interesting results and evaluation of the approach by conducting experiments using the MIT Lincoln lab evaluation data.
Photoacoustic imaging of real-time oxygen changes in chronic leg ulcers after topical application of a haemoglobin spray: a pilot study (2016)

Joachim Dissemond received financial support from the company SastoMed for several scientific projects as well as for lectures and as an advisor. The haemoglobin spray was provided by SastoMed GmbH (Georgsmarienhütte, Germany).
Pharmacophore Modeling and Molecular Docking Led to the Discovery of Inhibitors of Human Immunodeficiency Virus-1 Replication Targeting the Human Cellular Aspartic Acid−Glutamic Acid−Alanine−Aspartic Acid Box Polypeptide 3 (2008)

HIV-1 replication has been inhibited by using a compound able to target the human cellular cofactor DEAD-box ATPase DDX3, essential for HIV-1 RNA nuclear export. This compound, identified by means of a computational protocol based on pharmacophoric modeling and molecular docking calculations, represents the first small molecule with such a mechanism of action and could lay the foundations for a pioneering approach for the treatment of HIV-1 infections.
Teachability and Personality of Learning Disabled Children: Prediction of Teachers' Perceptions from Personality Variables (1986)

Teacher perceptions of learning disabled (LD) pupils and a ma tched non-LD group were predicted based on child variance and personality variables. Teachers' perceptions of LD pupils were not related either to achievement or to verbal IQ. A four- variable model including three self-concept subscales and a locus of control subscale predicted variance in teachability of LD pupils yielding an R 2 of .50. The results suggest that teachers are using a different, relatively lenient standard of judgment when assessing the teachability of LD students. Implications for treatment and evaluation of mainstream placements are discussed.
Apparent binding of ionized calcium by various buffers. (1985)

Using different substance concentrations in an aqueous 1.25 mmol/L solution of CaCl2 plus NaCl to a final solution ionic strength of 160 mmol/L, we tested six buffers for their effect on measurements of ionized calcium (Ca2+). Measured Ca2+ decreased with increasing ionic strength and pH. Increasing concentrations of Tris caused a positive Ca2+ electrode bias; the other five buffers caused a negative Ca2+ electrode bias with increasing concentration. 4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid ("HEPES") at 10 mmol/L maintained pH 7.39 in the aqueous reference solutions containing 0.75 to 2.50 mmol of CaCl2 per liter, and showed a linear Ca2+ response among three different suppliers of Ca2+ instruments; it is thus a suitable buffer for a reference solution.
Air bag impact attenuation system for the AQM-34V remote piloted vehicle (1982)

This paper describes the air bag impact attenuation system for the AQM-34V remote piloted vehicle. The developed hardware, consisting of the main bag, tail bag, and inflation systems, is described. Operation of the system from electrical initiation through cover deployment, main and tail bag inflation, and ground impact is discussed. Development ground drop tests, environmental tests, structural tests, and the contractor flight tests are summarized. Test results substantiated system performance.
Prevalence of KRAS, BRAF, NRAS, PIK3CA, and PTEN alterations in colorectal cancer: Analysis of a large international cohort of 5,900 patients. (2014)

399 Background: Colorectal cancer (CRC) is the third most common cancer worldwide, with metastatic disease accounting for 40 to 50% of newly diagnosed patients. EGFR monoclonal antibodies (Mab), cetuximab and panitumumab, are effective treatment for KRAS wild type CRC. Although mutations in KRAS predict resistance to EGFR Mab therapy, only 80% of CRC patients with KRAS wild-type (WT) status respond to treatment. This study is a retrospective evaluation of genomic alterations in the EGFR pathway such as alterations in KRAS, BRAF, NRAS, PIK3CA and PTEN that may predict lack of response to EGFR Mab therapy in CRC patients. Methods: A large database of 5,900 consecutive CRC patients was analyzed from 2011 onwards for demographics (sex, age, geography, site of tumor) and biomarkers that might correlate with response to EGFR Mab therapy. Comprehensive testing included gene sequencing for KRAS, BRAF, NRAS, PTEN, and PIK3CA (next-generation sequencing, Sanger, pyrosequencing) and immunohistochemistry for PTEN protein expression. Results: Analysis revealed the incidence of KRAS mutation of 42% which is consistent with published literature. Analysis of the KRAS WT cohort revealed a mutation rate of 13.8 % for BRAF, 6.8% for NRAS, and 40% for patients with either PTEN loss of expression/mutation or a PIK3CA mutation. Earlier studies support that mutations in NRAS, BRAF and activation of the PI3K pathway by PTEN/PIK3CA analysis result in lower response rates to EGFR Mab therapy in CRC. Furthermore, multiplex biomarker testing revealed the rare occurrence of concurrent mutations: 1/5,900 subject harboring a BRAF and NRAS mutations, 7/5,900 others with BRAF and PIK3CA mutations, and 8/5,900 subjects with NRAS and PIK3CA mutations. Conclusions: This is a comprehensive analysis of a large international cohort evaluating the prevalence of predictive molecular aberrations suspected of lack of response to EGFR Mab therapy in patients with WT KRAS. Prospective controlled studies are in progress to validate the role of BRAF, NRAS, PIK3CA, and PTEN in clinical management of CRC. It is imperative to further explore the molecular pathology of CRC beyond KRAS in patient selection for EGFR Mab therapy.
Wavelength-Scanned Tunable Diode Laser Temperature Measurements in a Model Gas Turbine Combustor (2007)

DOI: 10.2514/1.26624 Two tunable diode laser temperature sensors are compared for nonintrusive determination of gas temperature and temperature fluctuations in a swirl-stabilized atmospheric-pressure flame. Time-resolved temperature is inferred from the ratio of integrated absorbance of two selected H2O transitions observed by scanning the wavelength of a single diode laser. The first sensor uses direct absorption near 1:8 � m, and the second sensor uses wavelength-modulation spectroscopy with second-harmonic detection (WMS-2f) near 1:4 � m. Both sensors are based on the single-laser concept, which can make the system compact, rugged, low-cost, and simple to operate. The scanned-wavelength approach can minimize interference from emission and provide robust absorption measurements. Time-resolved and real-time (no postprocessing) temperature measurements are presented for both liquid and gaseous fuels, and asystematic comparison of the performance of the two sensors is reported. We find the two-lineabsorptionratiotohaveexcellentpotentialasatemperature-basedcontrolvariablefortheseswirl-stabilized flames.
Chiral separation of polychlorinated biphenyls using a combination of hydroxypropyl-γ-cyclodextrin and a polymeric chiral surfactant (2002)

Chiral separation of moderately to highly hydrophobic polychlorinated biphenyls (PCBs) using a conventional chiral micelle or a polymeric chiral surfactant, as the single chiral selector is very difficult since the hydrophobic interactions between the chiral PCB and the monomeric or polymeric surfactant is very strong. Combined use of a polymeric chiral surfactant, polysodium N-undecanoyl-D-valinate (poly-D-SUV) with hydroxypropyl-gamma-cyclodextrin (HP-gamma-CD) was successful in cyclodextrin modified electrokinetic chromatography (CD-EKC) enantioseparation of PCB congeners. Addition of HP-gamma-CD to the background electrolyte containing poly-D-SUV functioned to improved chiral resolution for the PCBs and reduce the analysis time for these congeners. In addition, concentration of methanol, concentration of 2-(N-cyclohexylamino) ethanesulfonic acid (CHES) buffer and separation voltage was also varied to optimize multicomponent separation of five chiral PCBs. Simultaneous separation and enantioseparation of all five PCBs was possible in less than 50 min under optimized conditions that requires a 5 mM CHES solution buffered at about pH 10 with 1.5% w/v (ca. 60 mM) poly-D-SUV and 16 mM HP-gamma-CD. In addition, 1 M urea and 20% v/v methanol should be added as organic modifier and the capillary temperature maintained at 45 degrees C. As expected the polymeric surfactant showed improved chiral resolution of PCBs over conventional micelles of SUV. Under optimized conditions, when CD-EKC of chiral PCBs using poly-D-SUV was compared to sodium dodecyl sulfate (SDS), better resolution, higher efficiency and shorter analysis time was achieved with poly-D-SUV.
Collagen degradation and platelet-derived growth factor stimulate the migration of vascular smooth muscle cells (2000)

Cell migration is a key event in many biological processes and depends on signals from both extracellular matrix and soluble motogenic factors. During atherosclerotic plaque development, vascular smooth muscle cells migrate from the tunica media to the intima through a basement membrane and interstitial collagenous matrix and proliferate to form a neointima. Matrix metalloproteinases have previously been implicated in neointimal formation and in this study smooth muscle cell adhesion and migration on degraded collagen have been evaluated. Vascular smooth muscle cells adhered to native intact collagen type I and to its first degradation by-product, 3/4 fragment (generated by collagenase-3 cleavage), unwound at 35 degrees C to mimic physiological conditions. PDGF-BB pre-treatment induced a fourfold stimulation of smooth muscle cell motility on the collagen 3/4 fragment whereas no increase in smooth muscle cell motility on collagen type I was observed. Cell migration on collagen type I was mediated by alpha2 integrin, whereas PDGF-BB-stimulated migration on the 3/4 collagen fragment was dependent on alphavbeta3 integrin. alphavbeta3 integrin was organised in clusters concentrated at the leading and trailing edges of the cells and was only expressed when cells were exposed to the 3/4 collagen fragment. Tyrphostin A9, an inhibitor of PDGF receptor-beta tyrosine kinase activity, resulted in complete abolition of migration of PDGF-BB treated cells on collagen type I and 3/4 fragment. These results strongly support the hypothesis that the cellular migratory response to soluble motogens can be regulated by proteolytic modification of the extracellular matrix.
Efficient and flexible synthesis of chiral γ- and δ-lactones (2008)

An efficient and highly flexible synthesis for chiral gamma- and delta-lactones with high enantiomeric purity is described (>99% ee and 57-87% overall yield). The protocol involves alkylation of chiral 1,2-oxiranes with terminally unsaturated Grignard reagents. Subsequent oxidative degradation (OsO(4)-Oxone) of the terminal double bond from chiral alk-1-en-5-ols and alk-1-en-6-ols affords 4- or 5-hydroxy acids and gamma- and delta-lactones after acidic workup. The flexibility and efficiency of the protocol is illustrated by the synthesis of several alkanolides and alkenolides, hydroxy fatty acids and dihydroisocoumarins.
Increase in laser repetition rate by spectral selection (1989)

An experimental and theoretical study into the use of Fabry-Perot etalons as static repetition rate upconverters outside the laser cavity is discussed. It is shown that the output repetition rate can be increased up to 12 times while maintaining high average power.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Blood Print Detection By Fluorescence (1987)

We have surveyed the current methods for detection of blood prints and have compared representative procedures from the standpoint of the general type of involved chemistry. We find that the methods that involve fluorescent products produce the greatest sensitivity in concert with laser fluorescence excitation. The ninhydrin/ZnCl<sub>2</sub> procedure is very effective for porous items, including cloth. Merbromin or dichlorofluorescein are effective for non-porous surfaces. Development of blood prints on surfaces that display overwhelming background fluorescence is best performed by peroxidase-type absorption methods.
Two-Step Formation of Streptavidin-Supported Lipid Bilayers by PEG-Triggered Vesicle Fusion. Fluorescence and Atomic Force Microscopy Characterization (2002)

We have used fluorescence microscopy, fluorescence photobleaching recovery (FPR), and atomic force microscopy (AFM) to investigate the formation of tethered lipid bilayers on plane aluminum oxide or glass surfaces. The bilayers were assembled with the help of a two-step methodology recently proposed for microporous templates (Proux-Delrouyre et al. J. Am. Chem. Soc. 2001, 123, 8313). The first step consists of the accumulation of intact biotinylated vesicles (PC + DOPE) on a streptavidin sublayer itself immobilized on the substrate. The second step, clearly time separated, is the deliberate triggering of bilayer formation with the help of poly(ethylene glycol) (PEG), a fusion agent of lipidic vesicles. AFM and FPR measurements confirm that the vesicles do not spontaneously fuse during the first step provided that the streptavidin sublayer is present on the substrate. On the contrary, the treatment with PEG provokes the fast formation of a continuous lipid bilayer, as attested at the hundred nanometer scale by the AFM images and at the hundred micrometer scale by the lateral diffusion of a fluorescent probe (D = 2.2 × 10-8 cm2 s-1 for NBD-DMPE at 22 °C).
Reproducibility of Lumbar Spine Range of Motion Measurements Using the Back Range of Motion Device (1999)

Study Design Single-group repeated measures for single rater reliability. Objectives: To describe the intratester reliability for measurements of active lumbar spine mobility and pelvic inclination during standing obtained with the back range-of-motion (BROM) device. Background The BROM device has often been used to quantify lumbar spine active range of motion. No studies have reported the reliability of the BROM device in a clinical setting. Methods and Measures One examiner measured all 3 planes of lumbar range of motion in 40 nonimpaired subjects. For each plane of motion, 2 BROM device measurements were made. Intraclass correlation coefficients were calculated to express the intratester reliability for each plane of motion measured. Results Intraclass correlation coefficients were in the range of 0.67 to 0.94 for lumbar measurements with the BROM device. Conclusions Intratester reliability was fair to poor for sagittal plane measurements and pelvic inclination. Measurements obtained by the same examiner for lumbar lateral flexion and rotation with the BROM device, however, were reliable. J Orthop Sports Phys Ther l999;29A70–477.
Real-Time Monitoring System for Parking Space Management Services (2013)

Real-Time Monitoring System for Parking Space Management Services is the evolution of traditional parking system that it does not only provide live information to users in order to make it easy for them to look for vacant parking lot, it also give authority to operators to monitor and perform simulations to illustrate the real parking system. The purpose of this project is to apply the principles of queue theory into parking system modeling. The queue system model enables the predictions of arrival and service time in the system through analysis and calculations. Aside of it, Graphical User Interface (GUI) is also designed and integrated into the parking system in order to allow parking zone operators to monitor the status of the parking lots and view the statistics of arrival rate, service time and so on. This project focuses on the system modeling and software development and implementation. It is expected that this project will be able to assist parking zone operators in designing their system that will work efficiently and generate high income. It will also provide convenience to the operators in managing the parking zone remotely. Users will also experience a time-saving and stress-free parking zone.
Mechanism of O2-sensitive red cell properties (2016)

In this issue of Blood , Chu et al show that oxygen, by changing the conformation of hemoglobin (Hb), modulates many red cell properties by altering its interaction with band 3, the major red cell membrane protein. 1