gebhart/patrepeval huggingface dataset:
Adaptive DSL Crosstalk Precancellation Design Using Low-Rate Feedback From End Users (2006)

The performance of extensions of digital subscriber line to higher data rates (VDSL) is limited by the effects of crosstalk among the wires in a bundle. For the downstream, a precoder can compensate for this. Without knowledge of the crosstalk channel matrix, the problem is to compute a suitable precoder based on limited feedback from the receivers. In this letter, an adaptive precoder design algorithm is derived. The algorithm works on a per-tone basis and assumes that each receiver sends back the sign of the symbol error to the transmitter. The algorithm computes the precoder iteratively using this information, without the need to estimate the crosstalk channel as an intermediate step. The asymptotic and acquisition performance is verified by simulations
Age of experience (2009)

Our youth-obsessed culture ignores the countless liberations of old age, says Stephen Wright
Single dose pharmacokinetics and pharmacodynamics of oral loprazolam in the elderly. (1985)

The pharmacokinetics of the benzodiazepine hypnotic, loprazolam (1.0 mg orally), and the pharmacodynamic response to single oral doses (0.5 mg and 1.0 mg) have been compared in young and elderly healthy volunteers. No difference between the groups in peak plasma concentration (Cmax) or in the time to peak (tmax) was found, but the elimination half-life t1/2,z and area under the plasma concentration-time curve (AUC) were significantly greater in the elderly group. The immediate effects of loprazolam on all three performance tests used (postural sway, critical flicker fusion threshold (CFFT) and choice reaction time (CRT] and on subjective sedation tended to be more pronounced in the elderly subjects, though intersubject variability in response was high in both groups. The corresponding plasma concentrations did not differ significantly between the two groups. The higher (1.0 mg) dosage was associated with significant residual (11 h) impairment of standing steadiness in the elderly subjects. No other hangover effects were observed. The results are compatible with previous evidence of increased 'sensitivity' to benzodiazepines in the elderly and suggest that a lower (0.5 mg) starting dose of loprazolam would be appropriate for older recipients. Further investigation would be necessary to establish whether clinically relevant accumulation of loprazolam occurs in the elderly following repeated dosage.
Homogeneous composites of ultrahigh molecular weight polyethylene and minerals. 1. Synthesis (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHomogeneous composites of ultrahigh molecular weight polyethylene and minerals. 1. SynthesisEdward G. Howard, Robert D. Lipscomb, Robert N. MacDonald, Barbara L. Glazar, Charles W. Tullock, and John W. ColletteCite this: Ind. Eng. Chem. Prod. Res. Dev. 1981, 20, 3, 429–433Publication Date (Print):September 1, 1981Publication History Published online1 May 2002Published inissue 1 September 1981https://pubs.acs.org/doi/10.1021/i300003a004https://doi.org/10.1021/i300003a004research-articleACS PublicationsRequest reuse permissionsArticle Views142Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Role of facial expressions in social interactions (2009)

The expressions we see in the faces of others engage a number of different cognitive processes. Emotional expressions elicit rapid responses, which often imitate the emotion in the observed face. These effects can even occur for faces presented in such a way that the observer is not aware of them. We are also very good at explicitly recognizing and describing the emotion being expressed. A recent study, contrasting human and humanoid robot facial expressions, suggests that people can recognize the expressions made by the robot explicitly, but may not show the automatic, implicit response. The emotional expressions presented by faces are not simply reflexive, but also have a communicative component. For example, empathic expressions of pain are not simply a reflexive response to the sight of pain in another, since they are exaggerated when the empathizer knows he or she is being observed. It seems that we want people to know that we are empathic. Of especial importance among facial expressions are ostensive gestures such as the eyebrow flash, which indicate the intention to communicate. These gestures indicate, first, that the sender is to be trusted and, second, that any following signals are of importance to the receiver.
REVIEWS OF BOOKS (2000)

REVIEWS OF BOOKS Paul Lafargue and the Flowering of French Socialism, 1882-1911. By Leslie Derfler. Cambridge, Mass. and London: Harvard University Press. 1998. xv + 369 pp. £32.50. ISBN 0 674 65912 0. H. S. JONES H. S. JONES University of Manchester Search for other works by this author on: Oxford Academic Google Scholar French History, Volume 14, Issue 3, September 2000, Pages 358–359, https://doi.org/10.1093/fh/14.3.358 Published: 01 September 2000
AFM study of forces in and structures of nematic liquid crystal interfaces on silanated glass (2001)

We have studied interfacial forces in MBBA, 5CB, 8CB and 12CB liquid crystals on DMOAP silanated glass substrates using a temperature controlled AFM in the force spectroscopy mode. In the bulk isotropic phase all these interfaces are clearly divided into two regions. The first molecular layer, which is absorbed to the glass surface, is smectic-like and shows submicron holes; this layer covers approximately 70% of the surface and is in all cases stable far beyond the clearing point. It is followed by a partially ordered region, which is different for different materials. We observe pre-nematic ordering in 5CB, pre-smectic ordering in 8CB and well developed layer-by-layer ordering in 12CB.
Propulsion trade studies for spacecraft swarm mission design (2018)

Spacecraft swarms constitute a challenge from an orbital mechanics standpoint. Traditional mission design involves the application of methodical processes where predefined maneuvers for an individual spacecraft are planned in advance. This approach does not scale to spacecraft swarms consisting of many satellites orbiting in close proximity; non-deterministic maneuvers cannot be preplanned due to the large number of units and the uncertainties associated with their differential deployment and orbital motion. For autonomous small sat swarms in LEO, we investigate two approaches for controlling the relative motion of a swarm. The first method involves modified miniature phasing maneuvers, where maneuvers are prescribed that cancel the differential ΔV of each CubeSat's deployment vector. The second method relies on artificial potential functions (APFs) to contain the spacecraft within a volumetric boundary and avoid collisions. Performance results and required ΔV budgets are summarized, indicating that each method has advantages and drawbacks for particular applications. The mini phasing maneuvers are more predictable and sustainable. The APF approach provides a more responsive and distributed performance, but at considerable propellant cost. After considering current state of the art CubeSat propulsion systems, we conclude that the first approach is feasible, but the modified APF method of requires too much control authority to be enabled by current propulsion systems.
Relationship Between Long Durations and Different Regimens of Hormone Therapy and Risk of Breast Cancer (2003)

These data suggest that use of CHRT is associated with an increased risk of breast cancer, particularly invasive lobular tumors, whether the progestin component was taken in a sequential or in a continuous manner.
Monoclonal antibody OKT11A inhibits and recombinant interleukin 2 (IL 2) augments expression of IL 2 receptors at a pretranslational level. (1985)

The expression of receptors for interleukin 2 (IL 2) represents a critical event regulating the growth of normal T lymphocytes. We investigated the effects of the inhibitory monoclonal antibody OKT11A (anti-sheep erythrocyte receptor) and of purified recombinant IL 2 (rIL 2) on the expression of IL 2 receptors by activated T cells at both the protein and the mRNA levels. Adding OKT11A antibody (0.5 microgram/ml) to phytohemagglutinin (PHA)-stimulated cultures of human peripheral blood mononuclear cells (PBMC) markedly suppressed cellular proliferation (assessed by [3H]thymidine incorporation) and IL 2 receptor expression (determined by immunofluorescence assay by using the anti-IL 2-receptor antibody, anti-Tac). Northern blot analysis performed with the use of a cDNA probe specific for the human IL 2 receptor gene demonstrated that OKT11A antibody also decreased the accumulation of IL 2 receptor mRNA induced by PHA in PBMC. Purified rIL 2 (10 U/ml) alone had little effect on the expression of IL 2 receptors in unstimulated PBMC cultures. In combination with PHA or with PHA plus OKT11A, however, rIL 2 augmented both the expression of IL 2 receptor protein on PBMC and the accumulation of IL 2 receptor mRNA in PBMC. Adding anti-Tac antibody to PBMC cultures to block the interaction of IL 2 with its receptor diminished the accumulation of IL 2 receptor mRNA induced by PHA. Taken together, these data demonstrate that OKT11A antibody inhibits and IL 2 augments expression of IL 2 receptors on PHA-stimulated T cells, at least in part, at a pretranslational level.
Some experiments on vector quantization using neural nets (2002)

Some applications of neural network algorithms for the design of vector quantizer codebooks are presented. Vector quantization has been applied to the problem of displaying natural images with a reduced set of colors (color palette) and to the interframe coding of image sequences. Self-organizing feature maps and competitive learning (CL) algorithms have been used for the codebook design and their results are compared with those obtained using a classical LBG (Linde, Buzo, Gray) algorithm. The best results are obtained using a CL algorithm with a new initialization strategy. With this technique the codebook design is very fast, and some experiments have been carried out in order to introduce adaptive vector quantization in the interframe coder. Frame by frame the codebooks used to quantize the most important information are updated and then the more active parts of the motion-compensated luminance differences are quantized with these new codebooks. A considerable rise of the coder performance was obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Circulating Omega-3 Fatty Acids and Neovascular Age-Related Macular Degeneration (2014)

The RBCM EPA and EPA+DHA, as long-term biomarkers of n-3 dietary PUFA status, were associated strongly with neovascular AMD and may represent an objective marker identifying subjects at high risk for neovascular AMD, who may most benefit from nutritional interventions. (http://www.controlled-trials.com/isrctn number, ISRCTN98246501).
Thalidomide and dexamethasone for resistant multiple myeloma (2003)

Between November 1998 and April 2000, the combination of thalidomide and dexamethasone was evaluated in 47 consecutive patients with multiple myeloma that was resistant to prior high-dose dexamethasone-based therapies. Remission was observed in 22 patients (47%), including six patients with complete remission. Side-effects were frequent, mild and usually reversible, but deep vein thrombosis occurred in 8% of patients. Survival and remission times were longer among patients treated for previous resistant disease rather than for resistant relapse. This experience supports the use of thalidomide-dexamethasone in myeloma patients with resistant disease and justifies further trials in newly diagnosed patients.
<title>Taper Measurement Techniques</title> (1973)

A sudden increase in the availability of low cost fiber optic tapers has given rise not only to many new and interesting applications, but also to a myriad of measurement and specification difficulties. As with all fiber optic components, the method of specifying and measuring the optical parameters has not been easy. These difficulties, however, are compounded in the case of fiber optic tapers. This paper will endeavor to explain why a variation in fiber diameter along the length of the taper greatly complicates the measurement gathering process for distortion, transmittance and resolution. In addition, measurement techniques based on the fiber diameter variation will be explained.
Naturally Occurring Variations Modulate the Activity of the HPV33 Early Promoter and its Affinity for the E2 Transcription Factor (2018)

The human papillomavirus (HPV) Long Control Region (LCR) encompasses the early promoter (EP) that drives transcription of the E6 and E7 oncogenes in keratinocytes and HPV-associated cancers. In this study, the transcriptional activities of the HPV33 EP from the prototype LCR and from eight variants representative of the worldwide diversity of the virus were examined in primary human keratinocytes (PHK) and in the HeLa cervical carcinoma cell line by luciferase reporter-gene assays. Remarkably, the two variations with the greatest effect on the EP in PHK were C7732G and a 79-bp deletion that were associated with high-grade cervical lesions and persistent infections, respectively, in epidemiological studies. In contrast, the three variations most active in HeLa cells were C7537A, A7874C and A7879G. A7874C, which lies within an E2-binding sequence, is also shown to increase the activity and binding of E2 at this site. Collectively, these results indicate that naturally-occurring variations affect the HPV33 EP differentially in PHK than in cancer cells and, furthermore, that they can also alter its regulation by E2. These findings provide a molecular basis for rationalizing the results of previous epidemiological studies and for understanding the contribution of LCR polymorphisms to the oncogenicity and persistence of HPV33 infections.
MAid: mobility assistance for elderly and disabled people (2002)

The authors describe the mechatronic design and the control system of a so-called intelligent wheelchair. The task of this system is to transport people with severely impaired motion skills. The system provides functions ranging from fully autonomous navigation in an unknown crowded environment such as a railway station to partially autonomous local maneuvers such as passing narrow door ways, operating in narrow, cluttered space, or entering a cabin in a restroom.
Helical Supramolecules and Fibers Utilizing Leucine Zipper-Displaying Dendrimers (2003)

We describe a new family of discrete supramolecules comprising leucine-zipper peptides noncovalently assembled upon cognate leucine zippers fused to a dendrimer core. Circular dichroism and sedimentation equilibrium experiments clearly demonstrate that each leucine-zipper dendrimer (D-EZ4 or D-KZ4) can noncovalently display four leucine zippers on their surface that can be utilized for the multivalent display of protein cargo. Furthermore, we show that matched leucine-zipper dendrimers (D-EZ4/D-KZ4) can self-organize into fibers at neutral pH, providing a new scaffold for nanotechnology.
Melting of Ordered Arrays and Shape Transitions in Highly Concentrated Diblock Copolymer Solutions (1997)

Polystyrene/polyisoprene (PS/PI) diblocks suspended in decane serve as a model system for the investigation of highly concentrated diblock copolymer solutions. Bulk melts of PS/PI with no solvent exhibit ordered morphologies including lamellae, close-packed cylinders, etc. that depend on the block asymmetry. These same diblocks self-assemble in decane at low concentrations to form monodisperse, spherical micelles with a dense polystyrene core and a diffuse polyisoprene corona. Strongly interacting polymeric micelles, observed at modest polymer concentrations, order into cubic arrays that include both face-centered and body-centered cubic crystals depending on the length scale of the repulsion relative to the core dimension. These ordered morphologies of the melt and micellar crystals provide limiting reference states for the poorly understood high-concentration regime studied in this work. As we increase the polymer concentration, we observe a curious melting of the micellar crystals before the onset of anisotropy. Since the melting of the micellar crystal is not predicated upon shape transitions, we return to tethered-chain models of our spherical polymeric micelles to qualitatively describe the disordering process in terms of a loss of the osmotic pressure gradient between micelles. One system exhibits a reentrant disorder−order−disorder−order phase transition. Finally, the development of anisotropy in the scattering pattern is linked to shape transitions that develop as melt conditions are approached. We monitor the degree of anisotropy to estimate the concentration for the onset of these shape transitions.
Receptor‐Specific Delivery of Protein Antigen to Dendritic Cells by a Nanoemulsion Formed Using Top‐Down Non‐Covalent Click Self‐Assembly (2013)

A new class of targeted and immune-evading nanocarrier made using only biological components and facile processes is assembled in a bottom-up fashion. Simple top-down sequential addition of immune-evading or receptor-specific antibody elements conjugated to biosurfactant protein DAMP4 promotes self-assembly at an interface previously formed in the presence of peptide surfactant AM1, leading to a functional display at the interface through non-covalent molecular self-assembly.
Abating progressive tissue injury and preserving function after CNS trauma: The role of inflammation modulatory therapies. (2010)

Brain and spinal cord injuries result in cognitive and/or sensorimotor impairments that can significantly diminish the quality of life for the patient and their carers, and result in healthcare system costs totaling in the billions. The current gold-standard of acute care for spinal cord injury is to administer high doses of glucocorticoids within 8 h of injury; administration after 8 h may be without effect or detrimental to the outcome of the patient. Therefore, improved pharmacological approaches for limiting the extent of tissue damage and neurological dysfunction in the acute injury setting are urgently needed. Early intervention in CNS injury by antagonizing or controlling the post-injury inflammatory process with pharmaceutical agents is a major focus of current clinical and preclinical investigations. In this editorial overview, recent clinical trials and preclinical studies of brain and spinal cord injuries are discussed, including studies focusing on the use of broad-spectrum immunosuppressive drugs (eg, minocycline); growth factors (eg, erythropoietin); dual anti-inflammatory and anti-vasospasm drugs, such as Rho and ROCK kinase inhibitors; and broad-spectrum anti-inflammatory drugs, such as PDE4 inhibitors. These new approaches hold great promise to improve outcomes for patients with brain and spinal injuries.
Femtosecond Dynamics of Resonantly Excited Excitons in Room-Temperature GaAs Quantum Wells (1985)

We investigate the effect of excess excitonic populations created by resonant ultrashort excitation on the optical-absorption properties of GaAs quantum wells. We find that under these conditions at room temperature excitons produce more absorption bleaching than equal densities of free-carrier pairs. This bleaching partly recovers as the excitons ionize to give free carriers. Hence, we directly measure the thermal ionization time of excitons at room temperature for the first time, and find that $\ensuremath{\tau}\ensuremath{\sim}300$ fs.
Complete biosynthesis of noscapine and halogenated alkaloids in yeast (2018)

Microbial biosynthesis of plant natural products from simple building blocks is a promising approach toward scalable production and modification of high-value compounds. The pathway for biosynthesis of noscapine, a potential anticancer compound, from canadine was recently elucidated as a 10-gene cluster from opium poppy. Here we demonstrate the de novo production of noscapine in <i>Saccharomyces cerevisiae</i>, through the reconstruction of a biosynthetic pathway comprising over 30 enzymes from plants, bacteria, mammals, and yeast itself, including 7 plant endoplasmic reticulum (ER)-localized enzymes. Optimization directed to tuning expression of pathway enzymes, host endogenous metabolic pathways, and fermentation conditions led to an over 18,000-fold improvement from initial noscapine titers to ∼2.2 mg/L. By feeding modified tyrosine derivatives to the optimized noscapine-producing strain we further demonstrated microbial production of halogenated benzylisoquinoline alkaloids. This work highlights the potential for microbial biosynthetic platforms to support the synthesis of valuable and novel alkaloid compounds, which can advance alkaloid-based drug discovery and development.
Reproductive health care and minors' rights. (1984)

The right of minors under the US Constitution to reproductive health care services has been established and supersedes any state laws that may conflict with federal constitutional priciples. It has been ruled by the US Supreme Court that minors as well as adults possess a constitutional right to privacy, including the right to choose abortion without 3rd party consent. However, the states of Indiana, Lojisiana, Massachusetts, Missouri, North Dakota, and Rhode Island have enacted judicial bypass schemes that require parental consent for minors' abortions if an alternative procedure is also provided whereby the minor receives a confidential hearing before a neutral 3rd party. Several states further require parental notification for abortion, although legal challenges have been directed against these statutes. In terms of contraception, a New York statute that prohibited the sale of nonprescription contraceptives to those under 16 years of age was ruled to constitute an unconstitutional burden on minors' right to privacy. Moreover, parental consent to contraception cannot be imposed as a requirement in a federally funded family planning program. Attempts are being made to attach a parental consent requirement to family planning services provided under Title X, but this provision is considered to undercut desired adolescent participation in such programs and will be challenged on constitutional grounds. Claims by parents that the provision of contraceptive services to their children on a confidential basis violates parents' right to the care, custody, and nurture of their children have been rejected. Finally, standards promulgated by the American Bar Association provide that a minor of any age consent to medical services or counseling for family planning, contraception, or sexually transmitted diseases, excluding sterilization, and treatment related to pregnancy, including abortion.