gebhart/patrepeval huggingface dataset:
Subchronic Vaginal Toxicity Studies of Alcide Allay® Gel and Liquid in Guinea Pigs (1987)

Alcide Allay, an antimicrobial preparation produced in gel and liquid forms, was evaluated for vaginal toxicity in guinea pigs. 1.0 g/kg Allay gel or placebo was administered intravaginally once per day over a 30 day period while 2.5 g/kg Allay liquid (containing either of two concentrations of sodium chlorite and lactic acid as active ingredients) or placebo was applied vaginally three times per day for 10 days. At the conclusion of the studies, hematology, blood and urine clinical chemistry tests and necropsies were performed. RBC, HGB, HCT, MCHC and direct bilirubin increased while CO2, SGPT and CPK decreased in blood after Allay liquid treatment. Creatinine, urea nitrogen and uric acid in urine were statistically reduced in the liquid groups. Hematology and clinical chemistry parameters were within the normal range of values reported in the literature for guinea pigs, indicating no clinical significance due to drug treatment. Significant differences in organ body/weight ratios were observed between controls and Allay gel and liquid groups. However, only the livers in the gel study and the vaginas in both studies were changed histologically.
Nickel as a Catalyst (1937)

The literature, both patent and general, on the use of nickel as a catalyst has been largely digested and summarized. Fields touched upon in the paper are, in order of presentation, oil and fat hardening, hydrogen and the oxides of carbon, hydrogenation of hydrocarbons, miscellaneous organic hydrogenations, hydrocarbon purification by hydrogenation, removal of sulfur from hydrocarbon oils by hydrogenation, artificial aging of distilled liquors, inorganic hydrogenations, dehydrogenation and polymerization of organic compounds, simultaneous hydrogenation and dehydrogenation, decomposition of carbon monoxide, carbon oxides and hydrocarbons, carbon monoxide and ammonia, carbon monoxide and steam, hydrogen from hydrocarbon gases, condensation, isomerization, esterification, hydration and dehydration, addition and elimination of halogens, oxidation of carbon, carbon monoxide and organic compounds, drying oils, oxidation of oils and fats, hydrogen and oxygen, oxidation of sulfides, miscellaneous reactions of sulfides, oxidation of sulfur dioxide, ammonia oxidation, oxidation of atmospheric nitrogen, bleaching, waste water purification, absorption, negative catalysis and inhibitors, miscellaneous organic reactions, miscellaneous inorganic reactions and electrochemical processes. Preceding the fields covered in the foregoing paragraph are a brief historical foreword and a discussion of the types of nickel materials and amounts consumed for catalyst material in North America and in parts of Europe. The paper is concluded with a general discussion of the properties of nickel and nickel compounds that have catalytic interest.
MMAP: modified maximum a posteriori algorithm for image segmentation in large image/video databases (2002)

Block-based feature extraction and clustering algorithms usually have to trade off between resolution and accuracy, as larger image block tends to generate more representative features at the expense of clustering resolution. We propose a new postprocessing technique for optimally combining the labeling results from overlapping image regions. This technique, the modified maximum a posteriori (MMAP) method, utilizes both local and global information from the neighborhood of the image region under consideration. Consequently, the resolution of the clustering becomes independent of the accuracy of the feature. Experimental results show dramatic improvement of the classification accuracy over methods that do not postprocess the clustering labels with the MMAP algorithm.
Security of the Misty Structure Beyond the Birthday Bound. (2013)

Abstract. In this paper, we first prove beyond-birthyday-bound security for the Misty structure. Specifically, we show that an r-round Misty structure is secure against CCA attacks up to O(2 rn r+7) query complexity, where n is the size of each round permutation. So for any ɛ&gt; 0, a sufficient number of rounds would guarantee the security of the Misty structure up to 2 n(1−ɛ) query complexity. 1
Protection by S-2-(3-aminopropylamino)ethylphosphorothioic acid against radiation-induced leg contractures in mice. (1983)

S-2-(3-Aminopropylamino)ethylphosphorothioic acid (WR-2721) was shown to provide marked protection against development of radiation-induced leg contractures in C3Hf/Kam mice whose legs were exposed to single doses of gamma-radiation. The radiation doses ranged from 3300 to 6200 rads delivered to the right hind thighs from two parallelly opposed 137Cs sources. WR-2721 was given i.p. 30 min before irradiation. The severity of radiation-induced leg contractures in untreated and WR-2721-treated mice was followed for 342 days after irradiation. The degree of leg contractures in both control and WR-2721-treated mice increased up to 100 days after radiation, when the change stabilized, remaining more or less at the same level to the end of the observation period. During this entire period, the severity of contractures was less in WR-2721-treated mice. The dose-modifying factor for the level of 5 mm reduction in leg extension was 1.5 at 182 days after irradiation. Since WR-2721 did not prevent the radiocurability of 8-mm fibrosarcomas growing in the same legs, these data imply that WR-2721 has a high potential for increasing therapeutic gain when combined with irradiation in the treatment of tumors of an appreciable size.
JPEG2000-Based Scalable Interactive Video (JSIV) With Motion Compensation (2011)

In a recent work, the authors proposed a novel paradigm for interactive video streaming and coined the term JPEG2000-Based Scalable Interactive Video (JSIV) for it. In this work, we investigate JSIV when motion compensation is employed to improve prediction, something that was intentionally left out in our earlier treatment. JSIV relies on three concepts: storing the video sequence as independent JPEG2000 frames to provide quality and spatial resolution scalability, prediction and conditional replenishment of code-blocks to exploit inter-frame redundancy, and loosely coupled server and client policies in which a server optimally selects the number of quality layers for each code-block transmitted and a client makes the most of the received (distorted) frames. In JSIV, the server transmission problem is optimally solved using Lagrangian-style rate-distortion optimization. The flexibility of JSIV enables us to employ a wide variety of frame prediction arrangements, including hierarchical B-frames. JSIV provides considerably better interactivity compared with existing schemes and can adapt immediately to interactive changes in client interests, such as forward or backward playback and zooming into individual frames. Experimental results show that JSIV's performance is inferior to that of SVC in conventional streaming applications while JSIV performs better in interactive browsing applications.
Who Really Made Your Car? (2008)

In the past few decades, the evolving relations between automakers and their parts suppliers have resulted in shifts in the location of production across North America. The authors explore the ongoing structural changes to the automotive industry and explain their local, regional, and international implications.
Hoard (2000)

Parallel, multithreaded C and C++ programs such as web servers, database managers, news servers, and scientific applications are becoming increasingly prevalent. For these applications, the memory allocator is often a bottleneck that severely limits program performance and scalability on multiprocessor systems. Previous allocators suffer from problems that include poor performance and scalability, and heap organizations that introduce false sharing. Worse, many allocators exhibit a dramatic increase in memory consumption when confronted with a producer-consumer pattern of object allocation and freeing. This increase in memory consumption can range from a factor of P (the number of processors) to unbounded memory consumption.This paper introduces Hoard, a fast, highly scalable allocator that largely avoids false sharing and is memory efficient. Hoard is the first allocator to simultaneously solve the above problems. Hoard combines one global heap and per-processor heaps with a novel discipline that provably bounds memory consumption and has very low synchronization costs in the common case. Our results on eleven programs demonstrate that Hoard yields low average fragmentation and improves overall program performance over the standard Solaris allocator by up to a factor of 60 on 14 processors, and up to a factor of 18 over the next best allocator we tested.
Microfluidic free‐flow zone electrophoresis and isotachophoresis using carbon black nano‐composite PDMS sidewall membranes (2016)

We present a new type of free-flow electrophoresis (FFE) device for performing on-chip microfluidic isotachophoresis and zone electrophoresis. FFE is performed using metal gallium electrodes, which are isolated from a main microfluidic flow channel using thin micron-scale polydimethylsiloxane/carbon black (PDMS/CB) composite membranes integrated directly into the sidewalls of the microfluidic channel. The thin membrane allows for field penetration and effective electrophoresis, but serves to prevent bubble generation at the electrodes from electrolysis. We experimentally demonstrate the ability to use this platform to perform on-chip free-flow electrophoretic separation and isotachophoretic concentration. Due to the small size and simple fabrication procedure, this PDMS/CB platform could be used as a part of an on-chip upstream sample preparation toolkit for portable microfluidic diagnostic applications.
A Disquisitive Plan on Model of Insulin Resistance (2009)

The animal model of insulin resistance has been developed rapidly,in order to better explore the combination of diseases and syndrome,we plan to adopt the way of high-fat and high-sugar diet establishing an animal model of insulin resistance,classical Chinese medicine treated after success of model.The way of classical Chinese medicine treating disease and syndrome has a larger value in the current.
Toll-Like Receptor Ligands Modulate Dendritic Cells to Augment Cytomegalovirus- and HIV-1-Specific T Cell Responses (2003)

Optimal Ag targeting and activation of APCs, especially dendritic cells (DCs), are important in vaccine development. In this study, we report the effects of different Toll-like receptor (TLR)-binding compounds to enhance immune responses induced by human APCs, including CD123(+) plasmacytoid DCs (PDCs), CD11c(+) myeloid DCs (MDCs), monocytes, and B cells. PDCs, which express TLR7 and TLR9, responded to imidazoquinolines (imiquimod and R-848) and to CpG oligodeoxynucleotides stimulation, resulting in enhancement in expression of costimulatory molecules and induction of IFN-alpha and IL-12p70. In contrast, MDCs, which express TLR3, TLR4, and TLR7, responded to poly(I:C), LPS, and imidazoquinolines with phenotypic maturation and high production of IL-12 p70 without producing detectable IFN-alpha. Optimally TLR ligand-stimulated PDCs or MDCs exposed to CMV or HIV-1 Ags enhanced autologous CMV- and HIV-1-specific memory T cell responses as measured by effector cytokine production compared with TLR ligand-activated monocytes and B cells or unstimulated PDCs and MDCs. Together, these data show that targeting specific DC subsets using TLR ligands can enhance their ability to activate virus-specific T cells, providing information for the rational design of TLR ligands as adjuvants for vaccines or immune modulating therapy.
Membrane Reactor Using Microporous Glass-supported Thin Film of Palladium. Application to the Water Gas Shift Reaction (1989)

Abstract A composite membrane consisting of palladium thin film and a microporous-glass tube was applied to a membrane reactor. In the water gas shift reaction, the membrane reactor gave the conversion level exceeding the equilibrium one for the closed system as a result of the separation of hydrogen produced.
Predicting next shopping stage using Google Analytics data for E-commerce applications (2019)

E-commerce web applications are almost ubiquitous in our day to day life, however as useful as they are, most of them have little to no adaptation to user needs, which in turn can cause both lower conversion rates as well as unsatisfied customers. We propose a machine learning system which learns the user behaviour from multiple previous sessions and predicts useful metrics for the current session. In turn, these metrics can be used by the applications to customize and better target the customer, which can mean anything from offering better offers of specific products, targeted notifications or placing smart ads. The data used for the learning algorithm is extracted from Google Analytics Enhanced E-commerce, which is enabled by most e-commerce websites and thus the system can be used by any such merchant. In order to learn the user patterns, only its behaviour features were used, which don't include names, gender or any other personal information that could identify the user. The learning model that was used is a double recurrent neural network which learns both intra-session and inter-session features. The model predicts for each session a probability score for each of the defined target classes.
Hormone production by cultures of small-cell carcinoma of the lung (1981)

Continuous cell lines have been established from a variety of biopsy and postmortem species of tumor from patients with small-cell carcinoma of the lung (SCCL) and have been maintained over several years. The medium from the cultures has been assayed for peptide, glycoprotein, and steroid hormones. Significant amounts of 14 hormones including calcitonin, adrenocorticotropin (ACTH), parathormone, luteinizing hormone, chorionic gonadotropin, glucagon, growth hormone, somatostatin, prolactin, beta-endorpin, lipotropin, oxytocin-neurophysin, vasopressin-neurophysin, and estradiol have been demonstrated. Up to ten different hormones have been produced by a single cell line. Most produce ACTH and all evaluated so far produce estradiol. These studies indicate that cells from SCCL have a potential for producing a wide variety of hormones and that this characteristic can be maintained for prolonged periods of culture in vitro.
Baseline and early post-treatment clinical and laboratory factors associated with severe neurotoxicity following 19-28z CAR T cells in adult patients with relapsed B-ALL. (2017)

7024 Background: CD19-specific chimeric antigen receptor (CAR) modified T cells produce high anti-tumor activity in relapsed or refractory (R/R) ALL, but can be associated with cytokine release syndrome (CRS) and neurotoxicity (NTX). Herein, we report baseline and post-treatment clinical and laboratory factors associated with severe NTX (≥Grade 3) in our phase I clinical trial of CD19-specific 19-28z CAR T cells for adult patients (pts) with R/R B-ALL (NCT01044069). Methods: 51 adult pts with R/R B-ALL were treated with 19-28z CAR T cells following conditioning chemotherapy at MSKCC. In order to identify clinical and serum biomarkers associated with severe NTX (sNTX), we examined demographic, treatment, and clinical blood parameters as well as in vivo CAR T expansion and serum cytokines, and performed univariate and multivariate analysis. Results: In this cohort of ALL pts, 20, 8, 2, 18 and 3 pts experienced Gr 0, 1, 2, 3, and 4 NTX, respectively. No pt developed grade 5 NTX. Disease burden (≥50% blasts) at the time of T cell infusion (p = 0.0045) and post-treatment ≥Gr3 CRS (p = 0.0010) were significantly associated with sNTX, but we found no association with age, weight, T cell dose, choice of conditioning chemotherapy (Flu/Cy s. Cy), and prior lines of treatment. Among the clinical and blood parameters, fever, low PLT, high ferritin and MCHC as well as elevated GM-CSF, IFNγ, IL-15, IL-5, IL-10, IL-2 at day 3 of T cell infusion at day 3 of T cell infusion were significantly associated with sNTX (all p < 0.01). While some of these cytokines were also elevated in severe CRS cases, IL-5 and IL-2 at day 3 were unique to sNTX. Furthermore, in vivo peak CAR T expansion at day 7 (p = 0.0001) significantly correlated with sNTX (p < 0.01). Lastly, multivariate analysis revealed baseline PLT < 60 or MCHC > 33.2% and morphologic disease ( > 5% blasts) has 95% sensitivity and 70% specificity of identifying sNTX pts. Conclusions: These data provide a characterization of early clinical and serum biomarkers of sNTX in adult pts receiving 19-28z CAR T cells and should help identify appropriate pts for early intervention strategy to mitigate NTX. Clinical trial information: NCT01044069.
Synthesis and characterization of cellulose ion exchanger. II. Pilot scale and utilization in dye–heavy metal removal (1998)

Cotton fabric was converted into an ion exchanger by grafting it with (1) glycidyl methacrylate (GMA), followed by aminization with ethylene diamine; (2) dimethylaminoethyl methacrylate (DMAEMA), followed by quaternization; and (3) acrylic acid (AA). Grafting was carried out on a pilot scale using a thiocarbonate–H2O2 redox system. The so-obtained cotton graft copolymers were monitored for their ability to remove different dyes as well as heavy metals from aqueous solutions. It was found that the magnitude of dye exhaustion was as follows. For direct and reactive dyes the percentage of exhaustion follows the order of aminized GMA > quaternarized DMAEMA > DMAEMA, whereas for acid dye the percentage of exhaustion follows the order of quaternarized DMAEMA > DMAEMA > aminized GMA. On the other hand poly(AA)–cotton copolymer is very effective at removal of the basic dye. With respect to heavy metal ions removal, the copolymers show the following order: AA > aminized GMA > quaternarized DMAEMA > DMAEMA. While dichromate removal follows the order of quaternarized DMAEMA > DMAEMA > aminized GMA. © 1998 John Wiley & Sons, Inc. J Appl Polym Sci 68: 2151–2157, 1998
Human Immunodeficiency Virus Type 1 Envelope Epitope-Specific CD4<sup>+</sup>T Lymphocytes in Simian/Human Immunodeficiency Virus-Infected and Vaccinated Rhesus Monkeys Detected Using a Peptide-Major Histocompatibility Complex Class II Tetramer (2000)

A tetrameric recombinant major histocompatibility complex (MHC) class II-peptide complex was used to quantitate human immunodeficiency virus type 1 (HIV-1) envelope (Env)-specific CD4(+) T cells in vaccinated and in simian/human immunodeficiency virus (SHIV)-infected rhesus monkeys. A rhesus monkey MHC class II DR molecule, Mamu-DR*W201, and an HIV-1 Env peptide (p46) were employed to construct this tetrameric complex. A p46-specific proliferative response was seen in sorted, tetramer-binding, but not nonbinding, CD4(+) T cells, directly demonstrating that this response was mediated by the epitope-specific lymphocytes. Although staining of whole blood from 10 SHIV-infected Mamu-DR*W201(+) rhesus monkeys failed to demonstrate tetramer-binding CD4(+) T cells (<0.02%), p46-stimulated peripheral blood mononuclear cells (PBMCs) from 9 of these 10 monkeys had detectable p46 tetramer-binding cells, comprising 0.5 to 15.2% of the CD4(+) T cells. p46-stimulated PBMCs from 7 of 10 Mamu-DR*W201(+) monkeys vaccinated with a recombinant canarypox virus-HIV-1 env construct also demonstrated p46 tetramer-binding cells, comprising 0.9 to 7.2% of the CD4(+) T cells. Thus, Env p46-specific CD4(+) T cells can be detected by tetrameric Mamu-DR*W201-p46 complex staining of PBMCs in both SHIV-infected and vaccinated rhesus monkeys. These epitope-specific cell populations appear to be present in peripheral blood at a very low frequency.
THE EFFECT OF CERTAIN BENZAZOLE COMPOUNDS ON PLANT GROWTH AND DEVELOPMENT (1961)

K lingensmith , M. J. (Colgate U., Hamilton, N. Y.) The effect of certain benzazole compounds on plant growth and development. Amer. Jour. Bot. 48(1): 40–45. Illus. 1961.—A number of benzazoles, in particular benzimidazole, benzothiazole, and benzotriazole, were examined for their effects on growth of seedlings and established plants. Benzothiazole was the most active in repressing elongation of the primary root of cucumber. Benzimidazole and benzotriazole were about 1/10 as active. Adenine was without effect in reversing the benzazole‐induced inhibition of cucumber root elongation and, in fact, supplemented the inhibition caused by benzimidazole and benzothiazole. Application of benzotriazole to the root medium of bean, coleus, tomato, oat and wheat caused a pronounced inhibition of internodal elongation with a stimulation of axillary development. Distinct morphological changes were observed which did not correspond to those produced by other growth regulators. Application of benzimidazole to the root medium of several genera of plants resulted in injury to laminar tissue followed by desiccation, with no concomitant effect on the stem. Application of benzothiazole to the root medium induced development of adventitious roots in bean and tomato. This compound also caused initiation of roots on cultures of tobacco‐stem segments, while not suppressing bud development. The benzazoles tested seem to be of a different class of compounds from other growth regulators which have been studied. The responses elicited by treatment with each of the 3 benzazoles are distinctly characteristic and are dependent on the structure of the azole portion of the molecule.
Scalable Web Content Attestation (2009)

The Web is a primary means of information sharing for most organizations and people. Currently, a recipient of Web content knows nothing about the environment in which that information was generated other than the specific server from whence it came (and even that information can be unreliable). In this paper, we develop and evaluate the Spork system that uses the trusted platform module (TPM) to tie the Web server integrity state to the Web content delivered to browsers, thus allowing a client to verify that the origin of the content was functioning properly when the received content was generated and/or delivered. We discuss the design and implementation of the Spork service and its browser-side Firefox validation extension. In particular, we explore the challenges and solutions of scaling the delivery of mixed static and dynamic content using exceptionally slow TPM hardware. We perform an in-depth empirical analysis of the Spork system within Apache Web servers. This analysis shows Spork can deliver nearly 8,000 static or over 7,000 dynamic integrity-measured Web objects per-second. More broadly, we identify how TPM-based content Web services can scale with manageable overheads and deliver integrity-measured content with manageable overhead.