gebhart/patrepeval huggingface dataset:
Report on the Second International Workshop on Human Chromosome 9 (1993)

The Second International Workshop on Human Chromosome 9 was held in Chatham, Massachusetts on April 18--20, 1993. Fifty-three abstracts were received and the data presented on posters. The purpose of the meeting was to bring together all interested investigators working on the map of chromosome 9, many of whom had disease-specific interests. After a brief presentation of interests and highlighted results, the meeting broke up into the following subgroups for production of consensus maps: 9p; 9cen-q32; 9q32 ter. A global mapping group also met. Reports of each of these working groups is presented in the summary.
Three-Dimensional Simulation of Random-Dopant-Induced Threshold Voltage Fluctuation in Nanoscale Fin-Typed Field Effect Transistors (2007)

Nanoscale multiple‐gate fin‐typed field effect transistors (FinFETs) are promising candidates for next generation semiconductor devices. Impact of the discrete‐dopant number and discrete‐dopant position on device characteristics is crucial for nanoscale semiconductor devices. In this paper, we study the discrete‐dopant‐induced potential and threshold voltage fluctuations in 16nm triple‐gate FinFET devices. Discrete dopants are statistically positioned into the three‐dimensional channel region to examine associated carrier transportation characteristics, concurrently capturing “dopant concentration variation” and “dopant position fluctuation”. It is found that the inhomogeneity of the potential induced by the discreteness of the channel dopants significantly disturbs device threshold voltage, and thus the device characteristics. This study provides an insight into the source of fluctuation and fluctuations induced by discrete dopants in ultra‐small field effect transistors with vertical channel structures.
Divergent Pathways Mediate Spine Alterations and Cell Death Induced by Amyloid-β, Wild-Type Tau, and R406W Tau (2009)

Alzheimer's disease is characterized by synaptic alterations and neurodegeneration. Histopathological hallmarks represent amyloid plaques composed of amyloid-beta (Abeta) and neurofibrillary tangles containing hyperphosphorylated tau. To determine whether synaptic changes and neurodegeneration share common pathways, we established an ex vivo model using organotypic hippocampal slice cultures from amyloid precursor protein transgenic mice combined with virus-mediated expression of EGFP-tagged tau constructs. Confocal high-resolution imaging, algorithm-based evaluation of spines, and live imaging were used to determine spine changes and neurodegeneration. We report that Abeta but not tau induces spine loss and shifts spine shape from mushroom to stubby through a mechanism involving NMDA receptor (NMDAR), calcineurin, and GSK-3beta activation. In contrast, Abeta alone does not cause neurodegeneration but induces toxicity through phosphorylation of wild-type (wt) tau in an NMDAR-dependent pathway. We show that GSK-3beta levels are elevated in APP transgenic cultures and that inhibiting GSK-3beta activity or use of phosphorylation-blocking tau mutations prevented Abeta-induced toxicity of tau. FTDP-17 tau mutants are differentially affected by Abeta. While R406W tau shows increased toxicity in the presence of Abeta, no change is observed with P301L tau. While blocking NMDAR activity abolishes toxicity of both wt and R406W tau, the inhibition of GSK-3beta only protects against toxicity of wt tau but not of R406W tau induced by Abeta. Tau aggregation does not correlate with toxicity. We propose that Abeta-induced spine pathology and tau-dependent neurodegeneration are mediated by divergent pathways downstream of NMDAR activation and suggest that Abeta affects wt and R406W tau toxicity by different pathways downstream of NMDAR activity.
Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts. (1992)

Caveolae are flask-shaped plasma membrane invaginations abundant in endothelium and muscle but may be present in all cells. They contain a filamentous coat material thought to be important in their structure and function. Recent studies have demonstrated that a 22-kDa protein (caveolin) phosphorylated on tyrosine in Rous sarcoma virus-transformed chicken fibroblasts is a component of the caveolae coat on the inner aspect of the membrane. We now report the deduced protein sequence of chicken caveolin derived from cDNA PCR products and genomic DNA clones. Caveolin is a unique protein of 178 amino acids and displays little sequence similarity to other proteins in the GenBank data base. Hydrophobicity predictions indicate an unusual 40-amino acid hydrophobic region near the C terminus that may be used to anchor the protein to the membrane. When chicken caveolin was expressed in mouse 3T3 cells and detected by immunofluorescence microscopy, the typical caveolae pattern was observed. This includes brightly fluorescent membrane patches in many cases concentrated at the margin of cells and in arrays. Caveolae may be distinct from other membrane domains due at least in part to caveolin.
A design of multi-stage, multi-way microstrip power dividers with broadband properties (2004)

We investigate a design method of multi-stage, multi-way microstrip power dividers to construct a compact low-loss power divider with number of outputs. First, we describe an integration design technique of multi-way power dividers founded on the planar circuit approach in combination with segmentation method, and design broadband 3- and 4-way power dividers. Next, we successfully design a 9-way power divider consisting of 3-way dividers of two-stage structure using a similar technique. As a result, the fractional bandwidths of nearly 90%, 100%, and 85% are obtained, respectively. The validity of these design results is confirmed by HFSS and an experiment.
Composition of Virgin, Thermal, and Catalytic Naphthas from Mid-continent Petroleum (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComposition of Virgin, Thermal, and Catalytic Naphthas from Mid-continent PetroleumWilliam E. Cady, Robert F. Marschner, and Wendell P. CropperCite this: Ind. Eng. Chem. 1952, 44, 8, 1859–1864Publication Date (Print):August 1, 1952Publication History Published online1 May 2002Published inissue 1 August 1952https://pubs.acs.org/doi/10.1021/ie50512a040https://doi.org/10.1021/ie50512a040research-articleACS PublicationsRequest reuse permissionsArticle Views99Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Enzymatic properties of native and deglycosylated hybrid aspen (<i>Populus tremula</i>×<i>tremuloides</i>) xyloglucan endotransglycosylase 16A expressed in <i>Pichia pastoris</i> (2005)

The cDNA encoding a xyloglucan endotransglycosylase, PttXET16A, from hybrid aspen (Populus tremulaxtremuloides) has been isolated from an expressed sequence tag library and expressed in the methylotrophic yeast Pichia pastoris. Sequence analysis indicated a high degree of similarity with other proteins in the XTH (xyloglucan transglycosylase/hydrolase) gene subfamily of GH16 (glycoside hydrolase family 16). In addition to the conserved GH16 catalytic sequence motif, PttXET16A contains a conserved N-glycosylation site situated proximal to the predicted catalytic residues. MS analysis indicated that the recombinant PttXET16A expressed in P. pastoris is heterogeneous due to the presence of variable N-glycosylation and incomplete cleavage of the alpha-factor secretion signal peptide. Removal of the N-glycan by endoglycosidase H treatment did not influence the catalytic activity significantly. Similarly, site-directed mutagenesis of Asn93 to serine to remove the N-glycosylation site resulted in an enzyme which was comparable with the wild-type enzyme in specific activity and thermal stability but had clearly reduced solubility. Hydrolytic activity was detected neither in wild-type PttXET16A before or after enzymatic deglycosylation nor in PttXET16A N93S (Asn93-->Ser) mutant.
Effect of Plant Growth Regulators and Vitamins on Russula vinosa Growth (2001)

In this paper, the effects of plant growth regulators and vitamins on the growth of Russula vinosa , extracellular soluble protein secretion and the type of esterase isoenzyme were investigated. Esterase isoenzyme and extracellular soluble protein were analyzed by polyacrylamide gel eletrophoresis (PAGE).Results showed that a concentration of 100mg/L of vitamin E(V E) promotes mycelial growth and secretion of extracellular soluble protein and esterase isoenzyme . Among the tested plant growth regulators, only IBA(4 mg/L) provided a considerable increase in mycelial growth, extracellular soluble protein secretion and type of esterase isoenzyme.
Asymmetric Electrophilic α-Amidoalkylation, 9:<sup>1</sup>Highly Stereoselective Syntheses of 2-Substituted Piperidines (1991)

Enantiomerically pure 2-substituted piperidines 8 are synthesized by diastereoselective addition of various nucleophiles 2 to a chiral N-acyliminium ion with an N-acyl group as chiral auxiliary generated in situ from enamide 5 (1-{[(1S,3R)-3-methoxymethyl-2, 2,3- trimethyl-1-triphenylsiloxycyclopentyl]carbonyl}-1,2,3,4-tetrahydropyridine).
Treatment of Methyl <i>tert</i>-Butyl Ether Vapors in Biotrickling Filters. 2. Analysis of the Rate-Limiting Step and Behavior under Transient Conditions (1999)

Detailed experiments were performed with gas phase biotrickling filters treating vapors of methyl tert-butyl ether (MTBE), a gasoline additive of great environmental concern. A particular emphasis was placed on the analysis of the rate-limiting step, and it was found that the process was mostly limited by the biological reaction rather than by mass transfer. Further experiments involved the study of the dynamic behavior of the biotrickling filters under simulated field conditions. In all cases, the biotrickling filters adapted rapidly to the new conditions, and new steady states were obtained within hours. The relevance of the results and the implications as far as implementation of biotrickling filters for field MTBE treatment are discussed.
Building a multisite Web architecture (2002)

Any large organizations that first came online in the late 1990s are now facing the decision whether to upgrade their Web systems or to start anew. Given the speed with which new technologies are introduced in the Web environment, system deployment life cycles have shrunk significantly-but so have system life spans. After only a few years, an organization's Internet infrastructure is likely to need a major overhaul. In late 2001, the systems architecture team to which I belong took on these issues for an organization that wanted to rebuild its Web infrastructure. The existing infrastructure contained multiple single points of failure, could not scale to expected usage patterns, was built on proprietary systems, and had a high management overhead. The legacy infrastructure had grown organically over the previous five years as administrators added unplanned features and functionality, and usage had grown 100-fold since the specifications were initially developed. Because of the age and condition of the legacy systems, we decided to redesign the solution from scratch to overcome the inherent limitations. This case study describes the process our systems architecture team followed for designing and deploying the new architecture. I detail the component selection rationale, with implementation details where allowed. Ours is just one successful approach to deploying a. multisite, fully redundant Web-based system for a large organization; other reasonable and viable ways to build such a system also exist.
Analysis of microstrip‐magnetostatic wave resonators (1989)

Abstract This paper analyzes a microstrip‐type magnetostatic wave resonator made of a YIG film loaded with a metal disk. First, based on a simple model consisting of a magnetic wall at the edge of the disk, the relationship between the resonant frequency and the aspect ratio and the Q value was investigated. Next, a more realistic model is set up and analyzed by the mode matching technique. The relationship between various resonator parameters and the energy trapping situation of the magnetostatic wave in the disk is found. Also the distribution of the RF magnetization in the disk is presented.
Research on Online Payment Mode Based On Internet Banking Payment Gateway (2007)

In order to make online payment mode based on Internet banking payment gateway (IBPG) sever the e-business better, there are important realistic meanings to study its business process, security authentication, interface standard and technical realization. Have described the basic online payment process of this mode; have probed into the realization way of this mode from respects, such as system structure, system function and security authentication process; have analyzed two typical kinds of security authentication schemes: China Finance Certification Authority (CFCA) authentication and banking self-built Certification Authority(CA) authentication; have discussed the advantage of this mode, such as being safety, being swift and defending denying; have analyzed the limitation of this mode from these respects: interface standard, security authentication, payment and business process, data to deposit in his own way and across banking payment obstacle. Point out that online payment mode based on the IBPG can not meet demands of e-business; propose basic thinking of one online payment mode that can solve the limitations of this online payment mode.
Application of amplitude histograms to monitorperformance of optical channels (1999)

A novel method for performance monitoring of transparent optical systems, based on the evaluation of amplitude histograms generated by asynchronous sampling, is investigated experimentally. The method was found to detect signal degradations due to noise, crosstalk or pulse distortion with a high sensitivity.
A new family of polyphase sequences for CDMA with good odd and even correlation properties (2003)

In this paper, we propose and investigate a new signature sequence family for use in asynchronous direct-sequence code-division multiple-access (DS-CDMA) communication systems. The new sequence family offers good correlation properties in both even and odd correlation. This can result in good performance on system capacity, acquisition and demodulation in DS-CDMA systems. The correlation properties of the new sequence family are presented. Based on the measure described in this paper, the correlation properties of the new sequence set are compared to those of the well-known conventional PN sequence sets.
Design and evaluation of fault-tolerant interleaved memory systems (2002)

A highly reliable interleaved memory system for uniprocessor and multiprocessor computer architectures is presented. The memory system is divided into groups. Each group consists of several banks and furthermore, each bank has several memory units. Spare memory units as well as spare banks are incorporated in the system to enhance reliability. Reliability figures are derived to evaluate systems with various amounts of redundancy. The result shows that the system reliability can be significantly improved with little hardware overhead. User transparency in memory access is retained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mapping tailings around mine sites with reverse polarity airborne transient EM data (2008)

Reversed polarity (negative) transients have been observed in airborne EM data over tailings at the Fox mine (in Manitoba, Canada) and the Aldermac mine (in Quebec, Canada). In the latter case, the negatives were confirmed by PROTEM readings taken on the ground. The airborne and ground EM measurements have been modeled with a thin conductive layer at surface that is chargeable. Two resistivity/IP traverses did not show coincident conductive and chargeable material.
Direct Self-Assembly of Conductive Nanorods of Metal–Organic Frameworks into Chemiresistive Devices on Shrinkable Polymer Films (2016)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDirect Self-Assembly of Conductive Nanorods of Metal–Organic Frameworks into Chemiresistive Devices on Shrinkable Polymer FilmsMerry K. Smith, Kennedy E. Jensen, Polina A. Pivak, and Katherine A. Mirica*View Author Information Burke Laboratory, Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, United States*K. A. Mirica. E-mail: [email protected]Cite this: Chem. Mater. 2016, 28, 15, 5264–5268Publication Date (Web):July 14, 2016Publication History Received22 June 2016Revised13 July 2016Published online19 July 2016Published inissue 9 August 2016https://doi.org/10.1021/acs.chemmater.6b02528Copyright © 2016 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views5816Altmetric-Citations133LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (3 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Electrodes,Metal organic frameworks,Polymer films,Sensors,Wires Get e-Alerts
Success And Failure Components Of Global Environmental Cooperation: The Making Of International Environmental Law (1995)

As this quotation suggests, international environmental problems have taken center stage since the end of the cold war, capturing the attention of scholars and diplomats alike. The number of scholarly articles devoted to the environment, particularly those focusing on international environmental problems, has increased dramatically in the past few years.
Intrinsic mechanisms of antinociception in inflammation: local opioid receptors and beta-endorphin (1990)

This study examined antinociception induced through the activation of local opioid receptors in inflammation by endogenous opioids. Rats developed a unilateral localized inflammation upon injection of Freund's adjuvant into one hindpaw. Four to 6 d later they were subjected to cold water swim (CWS), an environmental stimulus known to activate intrinsic opioid systems. Following CWS (1 min) the animals' withdrawal threshold to noxious pressure applied onto the paws increased significantly more on the inflamed paw than on the noninflamed paw. This unilateral antinociceptive effect in inflamed paws was dose-dependently and stereospecifically reversible by intraplantar (i.pl.) but not systemic (i.v. or s.c.) administration of the opioid antagonist naloxone (18 micrograms). This suggested that CWS-induced antinociception in inflamed tissue was brought about by the activation of local opioid receptors. Antiinflammatory or vasoconstrictive events, as measured by paw volume and temperature, did not contribute to this unilateral antinociception. Receptor-selective antagonists indicated the involvement of mu- and delta- but not kappa-receptors. Intravenous application of a universal antibody to endogenous opioid peptides (3-E7) and a specific antibody to beta-endorphin, but not antisera against metenkephalin or dynorphin, abolished the CWS effect. Finally, the i.pl. injection of synthetic beta-endorphin (1-31) produced an antinociceptive effect in inflamed paws which was reversible by i.pl. naloxone and selective mu- and delta-receptor antagonists. These findings suggest that antinociception in inflamed tissue can be induced through the activation of local opioid receptors by endogenous beta-endorphin released during CWS.
Development of a precolumn capillary liquid chromatography switching system for coupling to mass spectrometry (1996)

A column switching system was developed for capillary liquid chromatography using a robust low back pressure precolumn (PC) for fast loading of large sample volumes. After loading, trapped analytes are transferred to the capillary separation column by a backflush linear gradient flow. The PC contained a small quantity of reversed-phase C18 material prepared in poly etheretherketone (PEEK) tubing, which is capped at both sides by means of high-performance liquid chromatography (HPLC) in-line filters. Gradient backflush elution provided an effective means for preconcentration and refocusing of analytes of different nature and polarity. The technique showed a clearcut improvement in separation efficiency as compared with switching systems using forward flow elution of the PC. The system was connected to continuous flow Fast Atom Bombardment (FAB)/mass spectroscopy for the analysis of steroids and peptides. Salts and polar compounds present in the sample were removed by extensive washing of the precolumn with an appropriate water percentage before their elution and separation. The preconcentration of diluted samples on the PC gave an increase in sensitivity of approximately two orders of magnitude as compared with wide-bore HPLC-CF (continuous flow) FAB using effluent splitting. © 1996 John Wiley & Sons, Inc.
Urban Edibles: Weeds (2012)

They invade your garden, tap your soil’s precious nutrients and grow quicker than lightning strikes. If you can’t beat them, eat them! Increase your garden’s yield by identifying the edible weeds and adding them to your harvest.
miRNome Profiling of Purified Endoderm and Mesoderm Differentiated from hESCs Reveals Functions of miR-483-3p and miR-1263 for Cell-Fate Decisions (2017)

Pluripotent stem cells hold great promise for regenerative medicine since they can differentiate into all somatic cells. MicroRNAs (miRNAs) could be important for the regulation of these cell-fate decisions. Profiling of miRNAs revealed 19 differentially expressed miRNAs in the endoderm and 29 in the mesoderm when analyzing FACS-purified cells derived from human embryonic stem cells. The mesodermal-enriched miR-483-3p was identified as an important regulator for the generation of mesodermal PDGFRA<sup>+</sup> paraxial cells. Repression of its target PGAM1 significantly increased the number of PDGFRA<sup>+</sup> cells. Furthermore, miR-483-3p, miR-199a-3p, and miR-214-3p might also have functions for the mesodermal progenitors. The endoderm-specific miR-489-3p and miR-1263 accelerated and increased endoderm differentiation upon overexpression. KLF4 was identified as a target of miR-1263. RNAi-mediated downregulation of KLF4 partially mimicked miR-1263 overexpression. Thus, the effects of this miRNA were mediated by facilitating differentiation through destabilization of pluripotency along with other not yet defined targets.