gebhart/patrepeval huggingface dataset:
Application of Polymer-Supported Enzymes and Reagents in the Synthesis of γ-Aminobutyric Acid (GABA) Analogues (2002)

Polymer-supported pig liver esterase was used for the resolution of meso-diesters. The enzyme can be recovered quantitatively from the reaction mixture by filtration and reused without significant loss of activity. Further transformation of the resulting enantiomerically enriched carboxylic acids through the application of polymer-supported reagents and scavengers provides a number of GABA-analogues.
Genome-wide and Ordered-Subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates (2005)

Our results further support 19p13 as harboring an autism susceptibility locus, confirm other linkage findings at 17q11.2, and demonstrate the need to analyze more discreet trait-based subsets of complex phenotypes to improve ability to detect genetic effects.
Localization of Novel Adiponectin Receptor Constructs (2006)

Adiponectin is one of the most abundant fat-derived hormones involved in a multitude of metabolism pathways. The receptors AdipoR1 and AdipoR2 of this metabolically active protein have been identified recently. AdipoR1 and AdipoR2 are most abundantly expressed in the skeletal muscle and in the liver, respectively. It has been postulated that although they both consist of seven transmembrane helices, they are distinct from other G protein-coupled receptors (GPCRs). We cloned both receptors as fusion proteins with enhanced yellow fluorescent protein (YFP) to determine their localization and orientation in the cell membrane. By confocal microscopy and immune staining we demonstrated that both receptor-YFP-fusion proteins are integral membrane proteins with the predicted topology--an intracellular N-terminus and an extracellular C-terminus. In parallel, comparative experiments were performed with the NPY Y2-receptor, a classical rhodopsin-like GPCR.
정신장애인의 체험홈 이용경험에 관한 연구 (2019)

이 연구의 목적은 정신장애인들의 체험홈 이용 경험을 깊이 있게 연구하고자 현상학적 접근을 활용하였다. 총 9명의 정신장애인들이 연구참여자로 모집되었으며, 2016년 9월부터 2018년 3월에 걸쳐 심층인터뷰를 통해 자료를 수 집하였다. 모든 자료는 녹음하였으며, 자료는 Colaizzi방법으로 분석하었다. 분석결과 6개의 주제모음, 17개의 하위주 제가 도출되었으며, 다음과 같다: 1) 생활터전의 혼란스러움, 2) 체험홈에서 느끼는 여유로움, 3) 나에 대한 인식이 변 화함, 4) 주도적인 행동을 선택함, 5) 스스로 살아가는 힘을 키움, 그리고 6) 진정한 삶에 통합함으로 나타났다. 연구 결과는 정신장애인을 위한 체험홈 프로그램 확대 및 프로그램 질 향상의 필요성을 제기한다. 이와 더불어, 정신장애 인에 대한 정신건강서비스 개입과 회복을 위하여 전문지식을 갖춘 사례관리자 확대가 정신보건영역에서 필요할 것으 로 사료된다.
Metabolic fate of platelet-activating factor in neutrophils. (1983)

1-O-[3H]Alkyl-2-acetyl-sn-glycero-3-phosphocholine (1-O-[3H]alkyl-2-acetyl-GPC) incubated with rabbit polymorphonuclear leukocytes was metabolized to 1-O-alkyl-2-acyl-GPC containing long chain groups at the 2 position. Within 5 min, 60% of the total label added to the cell suspension was found in the 1-O-[3H]alkyl-2-acyl-GPC. At earlier time points, 1-O-[3H]alkyl-2-lyso-GPC was present. No metabolites were detected that would indicate the ether bond had been cleaved or the polar head group had been altered by the cells. At subaggregating and subdegranulating concentrations of labeled 1-O-[3H]alkyl-2-acyl-GPC, the same pattern of product formation was observed. Furthermore, when 1-O-[3H]alkyl-2-lyso-GPC was added to the cells, it was taken up and acylated in the same manner as that from 1-O-alkyl-2-acetyl-GPC. The nature of the long chain acyl residues incorporated into the 2 position was then examined by argentation chromatography and high performance liquid chromatography. Argentation chromatography of 1-O-[3H]alkyl-2-acyl-3-acetylglycerols obtained from 1-O-[3H]alkyl-2-acyl-GPC after acetolysis indicated that mono-, di-, and tetraenoic fatty acids were the predominant molecular species being incorporated into the 2 position of the molecule (18, 55, and 18%, respectively). Furthermore, high performance liquid chromatographic analysis using synthetic 1-O-alkyl-2-acyl-GPC standards indicated that three fatty acids, linoleic, arachidonic, and oleic (50, 15, and 12%, respectively), were the major chains being incorporated into the 1-O-hexadecyl-linked species. Analysis of 1-O-[3H]alkyl-2-acyl-GPC derived from exogenously added 1-O-[3H]alkyl-2-lyso-GPC revealed the same distribution of acyl groups linked to the 2 position. The findings are consistent with a pathway in which two enzymatic activities are responsible for the metabolism of exogenous platelet-activating factor in the rabbit neutrophils: one that hydrolyzes the acetyl residue (acetylhydrolase) and another that transfers a fatty acyl chain to the 1-O-alkyl-2-lyso-GPC formed (possibly acyl-CoA:1-O-alkyl-2-lyso-GPC acyltransferase). These events appear to play an important role in inactivating this potentially lethal phospholipid.
Building software with SCons (2005)

Software creation is a complicated procedure. The proliferation of commercial and open-source packages means that a typical software package might have to know how to link to dozens of different libraries or other third-party software. It might even have to build some of those libraries from scratch, not to mention build itself (and the libraries) in many different versions for various operating systems and hardware platforms. A next-generation software build tool called SCons can greatly simplify the headaches involved in building complicated software projects. I'll demonstrate it by building a sample project that involves source code spread across multiple directories. We'll also build two versions of an external software package to link against: a debug version and an optimized version.
Java Challenge Software Project (1999)

Programming contests are a means of exploiting the problem solving capabilities of developers and they provide a forum for display of extraordinary programming skills. The Java Challenge (JC) Software Project is the saga of creating an automated, secure and responsive programming contest system for deployment on the Internet and to collect information about programming practices, habits, and trends in coding in such restricted environment. The methodology followed to design, implement, and evaluate such a system uses new technologies such as the WWW, mail filtering and sandboxing techniques. The current Java Challenge implementation runs the Java Challenge on a Solaris 2.6 platform under specified regulations. The scripts are developed in Perl. The security features of jdkl.2 have been researched and successfully implemented. The mode of entry acceptance is electronic mail in a specified format. Standard Unix features have been used for data archiving and information redirection. The JC software is an application package that conducts programming contests in an automated manner, provides a secure environment for evaluation and does web listing updates automatically.
Nick Adams and Post-Traumatic Stress Disorder (1997)

Asserts Nick suffers from posttraumatic stress disorder by comparing his behavior and thoughts in “A Way You’ll Never Be” and “Big Two-Hearted River” to criteria from the Diagnostic and Statistical Manual of Mental Disorders (1994).
Cyclophosphamide Increases Transgene Expression Mediated by an Oncolytic Adenovirus in Glioma-Bearing Mice Monitored by Bioluminescence Imaging (2006)

Approaches to improve the oncolytic potency of replication-competent adenoviruses include the insertion of therapeutic transgenes into the viral genome. Little is known about the levels and duration of in vivo transgene expression by cells infected with such "armed" viruses. Using a tumor-selective adenovirus encoding firefly luciferase (AdDelta24CMV-Luc) we investigated these questions in an intracranial mouse model for malignant glioma. Luciferase expression was detected by bioluminescence imaging, and the effect of the immunosuppressive agent cyclophosphamide (CPA) on transgene expression was assessed. Intratumoral AdDelta24CMV-Luc injection led to a localized dose-dependent expression of luciferase. Surprisingly, this expression decreased rapidly during the course of 14 days. In contrast, mice injected with nonreplicating Ad.CMV-Luc demonstrated stable transgene expression. Treatment of mice with CPA in combination with AdDelta24CMV-Luc retarded the loss of transgene expression. Staining of mouse brains for inflammatory cells demonstrated decreased tumor infiltration by immune cells in CPA-treated mice. Moreover, in immunodeficient NOD/SCID mice loss of transgene expression was less rapid and not prevented by CPA treatment. Together, our data demonstrate that transgene expression and viral replication decrease rapidly after intratumoral injection of oncolytic adenovirus in mouse brains and that treatment with the immunomodulator CPA prolongs viral-mediated gene expression.
A review of ferrites for microwave applications (1975)

Ferrimagnetic materials for microwave applications are reviewed with emphasis on the more recent advances. Specific areas of discussion include temperature sensitivity of the magnetization, microwave loss phenomena and the concept of effective linewidth, and the hysteresis loop in terms of the factors which influence its coercive force, remanence ratio, and stress sensitivity. The relations between specific chemical substitutions and the attendant magnetic properties are then summarized for the various spinel and garnet ferrite families of interest to the microwave device engineer. Finally, the ceramic preparation of ferrite materials is outlined with special focus on some of the newer techniques.
A computer interfaced high-stability temperature controller and heating stage for optical microscopy (1994)

In optical microscopy, as in many fields, it is sometimes necessary to observe and study phenomena that occur over very narrow temperature ranges. For this purpose a temperature controller and heating stage have been developed for use in optical microscopy with an average temperature stability within +or-2 mK. The temperature can be varied from sub-ambient temperatures up to 373 K. The temperature controller is also interfaced to a personal computer via a 16-bit digital to analogue converter which allows remote control and the heating stage to be heated and cooled at predetermined rates.
Energy-efficient scheduling of packet transmissions over wireless networks (2003)

The paper develops algorithms for minimizing the energy required to transmit packets in a wireless environment. It is motivated by the following observation: In many channel coding schemes it is possible to significantly lower the transmission energy by transmitting packets over a long period of time. Based on this observation, we show that for a variety of scenarios the offline energy-efficient transmission scheduling problem reduces to a convex optimization problem. Unlike for the special case of a single transmitter-receiver pair studied by (see Prabhakar, Uysal-Biyikoglu and El Gamal. Proc. IEEE Infocom 2001), the problem does not, in general, admit a closed-form solution when there are multiple users. By exploiting the special structure of the problem, however, we are able to devise energy-efficient transmission schedules. For the downlink channel, with a single transmitter and multiple receivers, we devise an iterative algorithm, called MoveRight, that yields the optimal offline schedule. The MoveRight algorithm also optimally solves the downlink problem with additional constraints imposed by packet deadlines and finite transmit buffers. For the uplink (or multiaccess) problem MoveRight optimally determines the offline time-sharing schedule. A very efficient online algorithm, called MoveRightExpress, that uses a surprisingly small look-ahead buffer is proposed and is shown to perform competitively with the optimal offline schedule in terms of energy efficiency and delay.
Pristane-induced arthritis in mice: V. Susceptibility to pristane-induced arthritis is determined by the genetic regulation of the T cell repertoire (1998)

The data support the hypothesis that PIA is a T cell-mediated disease. While pristane causes a polyclonal T cell expansion that gives rise to lymphadenopathy, the development of arthritis in susceptible strains of mice occurs due to the preservation of specific T cell subsets with the capacity to infiltrate synovial joints.
Total syntheses of amythiamicins A, B and C (2008)

Total syntheses of the thiopeptide antibiotics amythiamicins A, B and C are reported.
Position Statement on Human Aging (2002)

A large number of products are currently being sold by antiaging entrepreneurs who claim that it is now possible to slow, stop, or reverse human aging. The business of what has become known as antiaging medicine has grown in recent years in the United States and abroad into a multimillion-dollar industry. The products being sold have no scientifically demonstrated efficacy, in some cases they may be harmful, and those selling them often misrepresent the science upon which they are based. In the position statement that follows, 52 researchers in the field of aging have collaborated to inform the public of the distinction between the pseudoscientific antiaging industry, and the genuine science of aging that has progressed rapidly in recent years.
Novel Inhibitors Complexed with Glutamate Dehydrogenase (2009)

Mammalian glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of l-glutamate to 2-oxoglutarate using NAD(P)(+) as coenzyme. Unlike its counterparts from other animal kingdoms, mammalian GDH is regulated by a host of ligands. The recently discovered hyperinsulinism/hyperammonemia disorder showed that the loss of allosteric inhibition of GDH by GTP causes excessive secretion of insulin. Subsequent studies demonstrated that wild-type and hyperinsulinemia/hyperammonemia forms of GDH are inhibited by the green tea polyphenols, epigallocatechin gallate and epicatechin gallate. This was followed by high throughput studies that identified more stable inhibitors, including hexachlorophene, GW5074, and bithionol. Shown here are the structures of GDH complexed with these three compounds. Hexachlorophene forms a ring around the internal cavity in GDH through aromatic stacking interactions between the drug and GDH as well as between the drug molecules themselves. In contrast, GW5074 and bithionol both bind as pairs of stacked compounds at hexameric 2-fold axes between the dimers of subunits. The internal core of GDH contracts when the catalytic cleft closes during enzymatic turnover. None of the drugs cause conformational changes in the contact residues, but all bind to key interfaces involved in this contraction process. Therefore, it seems likely that the drugs inhibit enzymatic turnover by inhibiting this transition. Indeed, this expansion/contraction process may play a major role in the inter-subunit communication and allosteric regulation observed in GDH.
Secretome of Olfactory Mucosa Mesenchymal Stem Cell, a Multiple Potential Stem Cell (2016)

Nasal olfactory mucosa mesenchymal stem cells (OM-MSCs) have the ability to promote regeneration in the nervous system in vivo. Moreover, with view to the potential for clinical application, OM-MSCs have the advantage of being easily accessible from patients and transplantable in an autologous manner, thus eliminating immune rejection and contentious ethical issues. So far, most studies have been focused on the role of OM-MSCs in central nervous system replacement. However, the secreted proteomics of OM-MSCs have not been reported yet. Here, proteins secreted by OM-MSCs cultured in serum-free conditions were separated on SDS-PAGE and identified by LC-MS/MS. As a result, a total of 274 secreted proteins were identified. These molecules are known to be important in neurotrophy, angiogenesis, cell growth, differentiation, and apoptosis, and inflammation which were highly correlated with the repair of central nervous system. The proteomic profiling of the OM-MSCs secretome might provide new insights into their nature in the neural recovery. However, proteomic analysis for clinical biomarkers of OM-MSCs needs to be further studied.
Mean Inner Potentials in Oxidized Germanium Nanowires by Electron Holography (2005)

Journal Article Mean Inner Potentials in Oxidized Germanium Nanowires by Electron Holography Get access J Chung, J Chung University of Texas Austin Search for other works by this author on: Oxford Academic Google Scholar J-P Zhou, J-P Zhou University of Texas Austin Search for other works by this author on: Oxford Academic Google Scholar L Rabenberg L Rabenberg University of Texas Austin Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 11, Issue S02, 1 August 2005, Pages 588–589, https://doi.org/10.1017/S1431927605504471 Published: 01 August 2005
Functional MRI using steady‐state arterial water labeling (1998)

Flow-sensitive functional MRI (fMRI) was performed using steady-state arterial water labeling (SS-AWL). Arterial water labeling was accomplished by flow induced adiabatic fast passage. The signal intensity of the visual cortex in arterial water labeled images decreased by approximately 1.4% during visual stimulation of the brain. Acquisition of arterial water unlabeled and labeled images allows measurement of relative cerebral blood flow increase during brain activation. During visual stimulation, cerebral blood flow in the visual cortex increased by 17 to 35% as measured by SS-AWL. Quantitation of brain activation in terms of a physiological parameter using SS-AWL will facilitate comparative fMRI studies under different conditions.
Automatic Calibration of Multiple 3D LiDARs in Urban Environments (2019)

Multiple LiDARs have progressively emerged on autonomous vehicles for rendering a wide field of view and dense measurements. However, the lack of precise calibration negatively affects their potential applications in localization and perception systems. In this paper, we propose a novel system that enables automatic multi-LiDAR calibration without any calibration target, prior environmental information, and initial values of the extrinsic parameters. Our approach starts with a hand-eye calibration for automatic initialization by aligning the estimated motions of each sensor. The resulting parameters are then refined with an appearance-based method by minimizing a cost function constructed from point-plane correspondences. Experimental results on simulated and real-world data sets demonstrate the reliability and accuracy of our calibration approach. The proposed approach can calibrate a multi-LiDAR system with the rotation and translation errors less than 0.04 [rad] and 0.1 [m] respectively for a mobile platform.
Expression and Transport Function of Drug Uptake Transporters in Differentiated HepaRG Cells (2012)

HepaRG cells have the ability to differentiate into hepatocyte-like cells. Many papers have shown that these hepatocyte-like cells share several functional properties with intact human hepatocytes. However, although previous studies have indicated the partial maintenance of mRNA expression of drug transporters, their expression and function have not been quantitatively characterized. In the present study, the mRNA and protein expression levels and transport activities of hepatic uptake transporters, organic anion transporting polypeptides (OATPs) and Na(+)-taurocholate cotransporting polypeptide (NTCP) in HepaRG cells were compared with those in cryopreserved human hepatocytes. The mRNA expression levels of OATP1B1, OATP1B3, OATP2B1, and NTCP in HepaRG cells were 22-38%, 2-15%, 82-113%, and 191-247% of those in human hepatocytes, respectively. The relative protein expression of these transporters was comparable with their mRNA expression. We observed saturable uptake of typical substrates of NTCP and OATPs except for cholecystokinin octapeptide (OATP1B3-selective substrate), and Na(+)-dependent uptake of taurocholate was confirmed. Their relative uptake clearances were well explained by their mRNA and protein expression levels. Additionally, inhibition potencies of 12 OATP1B1 inhibitors were investigated both in HepaRG cells and in OATP1B1-expressing HEK293 cells to demonstrate the usefulness of HepaRG cells for the characterization of OATP1B1-mediated drug-drug interactions. The Ki values in both cell lines were comparable and showed significant correlation. These results suggest that the hepatic uptake transport function of OATP and NTCP transporters was relatively well maintained in HepaRG, although OATP1B3 function was too low to be detected.
The limits of patriotism (2004)

A common criticism of the cosmopolitan position in the contemporary debate is that it is unable to accommodate or account for the special and particular relationships and commitments that people have. One reason for this criticism is that some cosmopolitans themselves have generally tended to be dismissive or suspicious of special commitments, sometimes even treating them as instances of moral failure. Or, at any rate, they seem to give this impression. As one leading proponent of the cosmopolitan position, Charles Beitz, acknowledges, "the philosophical weakness most characteristic of cosmopolitan theories … is a failure to take seriously enough the associative relationships that individuals do and almost certainly must develop to live successful and rewarding lives" (Beitz 1999b, p. 291). Adapting T. M. Scanlon's observation "that principles could reasonably be rejected on the grounds that they left no room for valuing other things that are important in our lives" (Scanlon 1999, p. 160), we might say that an account of global justice that does not allow sufficient space for the special ties and commitments that people reasonably find valuable is one which people may reasonably reject.
Cosmetic benefits of natural ingredients. (2014)

Photoaging is a leading concern for patients and many of these patients will express a desire to utilize natural ingredients as treatment. Mushrooms, feverfew, green tea, licorice, olive oil, soy, and coffee berry have been shown to have antioxidant properties and may play a role in the treatment and prevention of photoaging. In this manuscript, the most recent select basic science and clinical studies examining the mechanisms and efficacy of these ingredients will be discussed.
Polymer/piezoelectric ceramic composites: Polystyrene and poly(methyl methacrylate) with PZT (1984)

Abstract Lead zirconate–titanate (PZT)/polymer composites have been prepared by in situ polymerization of styrene and methyl methacrylate around aligned, thin PZT rods. Hydrostatic piezoelectric coefficients (d̄ h and ḡ g h ) measured by a dynamic technique yielded figures of merit (d̄ h ḡ h ) roughly four times that of homogeneous PZT for as‐polymerized composites. When these composites were annealed at a temperature slightly below the glass transition temperature of the matrix polymer and repoled, d̄ h ḡ h increased nearly twofold due primarily to a reduction of the composite dielectric constant. The piezoelectric response was found to be essentially independent of frequency from 30 to 160 Hz.