gebhart/patrepeval huggingface dataset:
The Role of the Extracellular Matrix in the Development of Colorectal Cancer Liver Metastases (2004)

Conference Abstract| February 01 2004 The Role of the Extracellular Matrix in the Development of Colorectal Cancer Liver Metastases J.A. Conti; J.A. Conti *Division of Cancer Science, University of Southampton†Division of Infection, Inflammation and Repair, University of Southampton Search for other works by this author on: This Site PubMed Google Scholar R.C. Benyon; R.C. Benyon †Division of Infection, Inflammation and Repair, University of Southampton Search for other works by this author on: This Site PubMed Google Scholar J.N. Primrose; J.N. Primrose *Division of Cancer Science, University of Southampton Search for other works by this author on: This Site PubMed Google Scholar J.P. Iredale J.P. Iredale †Division of Infection, Inflammation and Repair, University of Southampton Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (2004) 106 (s50): 2P. https://doi.org/10.1042/cs106002P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation J.A. Conti, R.C. Benyon, J.N. Primrose, J.P. Iredale; The Role of the Extracellular Matrix in the Development of Colorectal Cancer Liver Metastases. Clin Sci (Lond) 1 February 2004; 106 (s50): 2P. doi: https://doi.org/10.1042/cs106002P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 2004 The Biochemical Society and the Medical Research Society2004 Article PDF first page preview Close Modal You do not currently have access to this content.
Design and Analysis of Majority Logic-Based Approximate Adders and Multipliers (2019)

As a new paradigm for nanoscale technologies, approximate computing deals with error tolerance in the computational process to improve performance and reduce power consumption. Majority logic (ML) is applicable to many emerging nanotechnologies; its basic building block (the 3-input majority voter, MV) has been extensively used for digital circuit design. In this paper, designs of approximate adders and multipliers based on ML are proposed; the proposed multipliers utilize approximate compressors and a reduction circuitry with so-called complement bits. An influence factor is defined and analyzed to assess the importance of different complement bits depending on the size of the multiplier; a scheme for selection of the complement bits is also presented. The proposed designs are evaluated using hardware metrics (such delay and gate complexity) as well as error metrics. Compared with other ML-based designs found in the technical literature, the proposed designs are found to offer superior performance. Case studies of error-resilient applications are also presented to show the validity of the proposed designs.
Purification and some properties of arylsulphatases A and B from rabbit kidney cortex (1977)

Arylsulphatases A and B (EC 3.1.6.1) of rabbit kidney cortex were purified 5250- and 7720-fold respectively by a multiple-column-chromatography method. The specific activity toward 4-nitrocatechol sulphate was 42mumol/min per mg for arylsulphatase A and 62 mumol/min per mg for arylsulphatase B. Each enzyme migrated as a single band on polyacrylamide-gel electrophoresis, and the enzyme activity corresponded to the band of protein on the gel. The rate of hydrolysis of ascorbic acid 2-sulphate by arylsulphatase A was three times that for cerebroside 3-sulphate. Arylsulphatase B hydrolysed UDP-N--acetylgalactosamine 4-sulphate and glucosamine 4,6-disulphate, but not galactosamine 6-sulphate.
Development of the ALOHANET (1985)

The development of the ALOHA system packet broadcasting network at the University of Hawaii illustrates a number of general principles about the relationship between information theory and the design of real information systems. An anecdotal account is given of the development of the ALOHA system, emphasizing the interaction of the theory and the design of the experimental network. In addition, some preliminary results are described on the comparison of ALOHA channels and spread spectrum channels when used for packet communications.
An efficient and flexible toolkit for composing customized method dispatchers (2007)

Abstract The standard dispatching mechanisms built into programming languages sometimes fail to satisfy the needs of the programmer. In the case of Java, the need for more flexibility has led to the development of a number of tools, including visitors and multi‐method extensions, that each add some particular functionality, but lack the generality necessary to support user‐defined dispatching mechanisms. In this paper we advocate a more modular approach to dispatching, and we present a tool, PolyD, that allows the programmer to design custom dispatching strategies and to parametrize many aspects of the dispatching process. PolyD exhibits excellent performance and compares well against existing tools. Copyright © 2007 John Wiley & Sons, Ltd.
Optical transitions and EPR properties of two-coordinated Si, Ge, Sn and related<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>H</mml:mi><mml:mo>(</mml:mo><mml:mi mathvariant="normal">I</mml:mi><mml:mo>)</mml:mo><mml:mo>,</mml:mo></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>H</mml:mi><mml:mo>(</mml:mo><mml:mi mathvariant="normal">II</mml:mi><mml:mo>)</mml:mo><mml:mo>,</mml:mo></mml:math>and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>H</mml:mi><mml:mo>(</mml:mo><mml:mi mathvariant="normal">III</mml:mi><mml:mo>)</mml:mo></mml:math>centers in pure and doped silica from<i>ab initio</i>calculations (1998)

The photoabsorption and photoluminescence properties of two-coordinated Si, Ge, and Sn defect centers and the magnetic interactions of the corresponding $[=\mathrm{S}\mathrm{i}\ensuremath{-}\mathrm{H}{]}^{\ifmmode\bullet\else\textbullet\fi{}},$ $[=\mathrm{G}\mathrm{e}\ensuremath{-}\mathrm{H}{]}^{\ifmmode\bullet\else\textbullet\fi{}},$ and $[=\mathrm{S}\mathrm{n}\ensuremath{-}\mathrm{H}{]}^{\ifmmode\bullet\else\textbullet\fi{}}$ structures, the $H(\mathrm{I}),$ $H(\mathrm{II}),$ and $H(\mathrm{III})$ centers, respectively, have been studied by means of ab initio quantum-chemical methods. Using cluster models and configuration interaction wave functions, we have determined the transition energies to the lowest singlet and triplet states and the corresponding emissions and lifetimes. The computed optical properties are in close agreement with those proposed for the two-coordinated centers in pure and doped silica. The hyperfine interactions of the paramagnetic $H(\mathrm{I}),$ $H(\mathrm{II}),$ and $H(\mathrm{III})$ centers have been studied using unrestricted Hartree-Fock and density-functional theory approaches. Also, in this case, the proposed assignments are consistent with the calculations. The results provide strong theoretical support to the proposal of the two-coordinated Si as the origin of one component of the 5.0 eV ${B}_{2}$ absorption band in amorphous silica.
<i>In vitro</i> and <i>ex vivo</i> evaluation of second‐generation histone deacetylase inhibitors for the treatment of spinal muscular atrophy (2006)

Among a panel of histone deacetylase (HDAC) inhibitors investigated, suberoylanilide hydroxamic acid (SAHA) evolved as a potent and non-toxic candidate drug for the treatment of spinal muscular atrophy (SMA), an alpha-motoneurone disorder caused by insufficient survival motor neuron (SMN) protein levels. SAHA increased SMN levels at low micromolar concentrations in several neuroectodermal tissues, including rat hippocampal brain slices and motoneurone-rich cell fractions, and its therapeutic capacity was confirmed using a novel human brain slice culture assay. SAHA activated survival motor neuron gene 2 (SMN2), the target gene for SMA therapy, and inhibited HDACs at submicromolar doses, providing evidence that SAHA is more efficient than the HDAC inhibitor valproic acid, which is under clinical investigation for SMA treatment. In contrast to SAHA, the compounds m-Carboxycinnamic acid bis-Hydroxamide, suberoyl bishydroxamic acid and M344 displayed unfavourable toxicity profiles, whereas MS-275 failed to increase SMN levels. Clinical trials have revealed that SAHA, which is under investigation for cancer treatment, has a good oral bioavailability and is well tolerated, allowing in vivo concentrations shown to increase SMN levels to be achieved. Because SAHA crosses the blood-brain barrier, oral administration may allow deceleration of progressive alpha-motoneurone degeneration by epigenetic SMN2 gene activation.
High Efficient Metal Powder Production by Gas Atomisation Process (2007)

The most important parameter for production of fine powders efficiently is the velocity of the atomizing gas. This can be achieved by increasing the pressure, but this way will not be economic. For that reason, to achieve supersonic velocities different nozzle designs are used in close coupled configuration for an efficient atomization. In this study, a new laval type nozzle was designed and manufactured. Using this nozzle tin powder was produced in close coupled system by using nitrogen gas at different operating conditions. The results showed that the increasing the gas pressure up to 1.47 MPa reduced the mean powder size down to 11.39 microns with a gas/melt mass flow rate ratio of 2.0. Powders are spherical in shape and have smooth surfaces.
Quantification of the fiber architecture and biaxial mechanical behavior of porcine intestinal submucosa (1999)

Porcine small intestinal submucosa (SIS) has been shown to serve as a remodelable tissue scaffold in a wide range of applications. Despite the large number of experimental studies, there is a lack of fundamental information on SIS anisotropic mechanical behavior and how this behavior changes postimplantation. As a first step in our study of remodeling biomaterials, we performed biaxial mechanical testing to quantify the anisotropic mechanical behavior and used small-angle light scattering (SALS) to quantify the gross fiber structure of fresh, unimplanted SIS. Structural results indicate that SIS displays primarily a single, continuous preferred fiber direction oriented parallel to the long axis of the intestine. Occasionally, two distinct fiber populations oriented at approximately +/-28 degrees with respect to the longitudinal axis could be distinguished. Consistent with this structure, SIS exhibited a nonlinear, anisotropic mechanical response with higher stresses along the longitudinal axis. Further, the circumferential stress-strain response was strongly affected by the maximum longitudinal strain level, but the maximum circumferential strain level only weakly affected the longitudinal stress-strain response. This asymmetric mechanical coupling suggests strong mechanical interactions on a fiber level. SIS stress-strain response also was similar to glutaraldehyde-treated bovine pericardium, attesting to the substantial strength of SIS in the fresh, untreated state. The results of this study will provide a basis for a future analysis of the structural and mechanical changes during the remodeling process.
On the origin of the uniaxial anisotropy in nanocrystalline soft-magnetic materials (1997)

Annealing induced uniaxial anisotropy in soft-magnetic nanocrystalline thin films of FeTaN and FeNbSiN has been investigated. It was found that there are several contributions to the uniaxial anisotropy. The direction and the size of some of these can be changed reversibly at temperatures lower than 200 °C, whereas much higher temperatures are needed for others. The nitrogen atoms in these alloys play an important role in the uniaxial anisotropy. The cooling down period is extremely important for the induction of the uniaxial anisotropy. Control of uniaxial anisotropy through appropriate annealing is critical to the application of these materials in magnetic recording devices. Knowledge of the induction, manipulability, and of the thermal stability is essential for finding the optimum annealing procedure and for the application of the material in a magnetic device.
Efficient file storage using content-based indexing (2005)

Content-based indexing [MCM01] is a technique of proven effectiveness for efficient transference of file contents over low bandwidth network links. Departing from this context, the natural step of extending the application of this technique to local file storage has been proposed by a number of storage solutions [CN02, QD02, BF04]. To some extent, all these solutions share a core storage model. File contents are divided into disjoint chunks of data, each of which is individually stored, along with a unique hash of its contents, in a repository of chunks. The actual files are then stored as sequences of possibly shared references to chunks in the repository.
Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer (2018)

Nonalcoholic fatty liver disease (NAFLD) is a major risk factor for liver cancer; therefore, its prevention is an important clinical goal. Ablation of phosphatase and tensin homolog (PTEN) or the protein kinase Hippo signaling pathway induces liver cancer via activation of AKT or the transcriptional regulators YAP/TAZ, respectively; however, the potential for crosstalk between the PTEN/AKT and Hippo/YAP/TAZ pathways in liver tumorigenesis has thus far remained unclear. Here, we have shown that deletion of both PTEN and SAV1 in the liver accelerates the development of NAFLD and liver cancer in mice. At the molecular level, activation of YAP/TAZ in the liver of Pten-/- Sav1-/- mice amplified AKT signaling through the upregulation of insulin receptor substrate 2 (IRS2) expression. Both ablation of YAP/TAZ and activation of the Hippo pathway could rescue these phenotypes. A high level of YAP/ TAZ expression was associated with a high level of IRS2 expression in human hepatocellular carcinoma (HCC). Moreover, treatment with the AKT inhibitor MK-2206 or knockout of IRS2 by AAV-Cas9 successfully repressed liver tumorigenesis in Pten-/- Sav1-/- mice. Thus, our findings suggest that Hippo signaling interacts with AKT signaling by regulating IRS2 expression to prevent NAFLD and liver cancer progression and provide evidence that impaired crosstalk between these 2 pathways accelerates NAFLD and liver cancer.
Production of yogurt ice cream at different acidity (2007)

Summary The effect of using yogurt on the viscosity, over‐run, melting characteristics, pH, acidity, microbiological aspects and sensory characteristics of ice cream was investigated. The ice cream mix in all groups was 10% fat, 18% sucrose, 12% MSNF (milk non‐fat solids), 0.8% stabiliser and 0.4% emulsifier. The use of yogurt instead of milk decreased the viscosity of ice cream mix and over‐run capacity of ice cream. There was no negative effect of yogurt on the melting characteristics of ice cream. The use of yogurt at 0.7% lactic acid exhibited a good first drop (beginning of the melting point) and melting time, but it was not statistically significant ( P > 0.05). The results of the sensory scores showed that yogurt ice cream produced using the yogurt at 0.7% lactic acid was statistically similar to the control group. It was concluded that the conversion of milk to yogurt for ice cream production can be made at acidity 0.7% lactic acid with no loss of ice cream quality. Higher levels than 0.7% lactic acid contribute to progressive loss of sensory quality.
Erbin Is a Protein Concentrated at Postsynaptic Membranes That Interacts with PSD-95 (2001)

Neuregulin is a factor essential for synapse-specific transcription of acetylcholine receptor genes at the neuromuscular junction. Its receptors, ErbB receptor tyrosine kinases, are localized at the postjunctional membrane presumably to ensure localized signaling. However, the molecular mechanisms underlying synaptic localization of ErbBs are unknown. Our recent studies indicate that ErbB4 interacts with postsynaptic density (PSD)-95 (SAP90), a PDZ domain-containing protein that does not interact with ErbB2 or ErbB3. Using as bait the ErbB2 C terminus, we identified Erbin, another PDZ domain-containing protein that interacts specifically with ErbB2. Erbin is concentrated in postsynaptic membranes at the neuromuscular junction and in the central nervous system, where ErbB2 is concentrated. Expression of Erbin increases the amount of ErbB2 labeled by biotin in transfected cells, suggesting that Erbin is able to increase ErbB2 surface expression. Furthermore, we provide evidence that Erbin interacts with PSD-95 in both transfected cells and synaptosomes. Thus ErbB proteins can interact with a network of PDZ domain-containing proteins. This interaction may play an important role in regulation of neuregulin signaling and/or subcellular localization of ErbB proteins.
A FEEDFORWARD NEURAL NETWORK CLASSIFIER MODEL: MULTIPLE CLASSES, CONFIDENCE OUTPUT VALUES, AND IMPLEMENTATION (1992)

The Athena model is a tree-like net for pattern classification. This paper presents the formalisms on which the model's internal representations and function are based. It also presents an adaptive algorithm to be used with this model. The adaptation is based on entropy optimization. The difficult problem of the optimization is handled by use of Fisher's multiple discriminants method. A method is also presented by which confidence values are produced for the overall classification decision. Finally, a data flow architecture using optical processing elements is considered for the model's implementation.
Ultra High-Resolution NMR: Sustained Induction Decays of Long-Lived Coherences (2011)

Long-lived coherences (LLCs) in homonuclear pairs of chemically inequivalent spins can be excited and sustained during protracted radio frequency irradiation periods that alternate with brief windows for signal observation. Fourier transformation of the sustained induction decays recorded in a single scan yields NMR spectra with line-widths in the range 10 < Δν < 100 mHz, even in moderately inhomogeneous magnetic fields. The resulting doublets, which are reminiscent of J-spectra, allow one to determine the sum of scalar and residual dipolar interactions in partly oriented media. The signal intensity can be boosted by several orders of magnitude by "dissolution" dynamic nuclear polarization (DNP).
Liver Allograft Rejection : An Analysis of the Use of Biopsy in Determining Outcome of Rejection (1987)

Two-hundred-seventy biopsy specimens from 47 patients undergoing liver transplants at the University of Minnesota were analyzed to determine if histological features could predict the eventual outcome of rejection episodes. Thirty-six patients (76.6%) rejected the transplant. Of these, five either suffered acute liver failure due to rejection (two cases) or developed chronic rejection (three cases). Features of significance in predicting such a bad outcome were arteritis, bile duct paucity, or simultaneous hepatocellular ballooning and hepatocellular dropout and necrosis. Other features, such as type and intensity of infiltrate, degree of bile duct damage, or simple presence of hepatocellular necrosis, were not predictive of outcome. Our conclusion is that biopsy is useful in predicting outcome. Since many of the histologic findings of predictive value were not present in initial pretreatment biopsy specimens, follow-up biopsies of patients being treated for rejection are recommended to assess efficacy of therapy.
Long-Term Experience With 5-alpha-Reductase Inhibitors. (2003)

Finasteride, a 5-alpha-reductase inhibitor, dramatically suppresses the production of dihydrotestosterone in men; thus, attention has turned to this agent for the treatment of benign prostatic hyperplasia (BPH). A number of randomized clinical trials have studied finasteride's effects on prostate size, BPH symptoms, flow rate, and prostate-specific antigen (PSA) level. Although the decrease in symptoms with finasteride therapy has been modest compared with more invasive treatments, its use has resulted in sustained reductions in prostatic volume and PSA level with minimal adverse effects. Fewer surgeries for BPH, as well as a decreased incidence of acute urinary retention, have also been seen with finasteride therapy. More research is needed to maximize the effectiveness of such medical therapy for BPH.
Magnetic field sensitivity of depolarized fiber optic gyros (1991)

Results are presented of experimental measurements and an analysis of the magnetic field sensitivity of several types of depolarized fiber-optic gyros. It was found that depolarized gyros of the Bohm et al. (1981) and Fredricks and Ulrich (1984) configuration (having one depolarizer in the loop) can be highly sensitive to magnetic fields, while depolarized gyros incorporating Pavlath and Shaw concept (i.e., having unpolarized light enter and exit the loop) are insensitive to magnetic fields. It is shown that a gyro having all the advantages of both designs can be obtained by incorporating two depolarizers, one between the polarizer and the loop coupler and the other within the loop. A scheme of this type of fiber gyro is presented.
Isotypic pattern of the polyclonal B cell response during primary infection by <i>Plasmodium chabaudi</i> and in immune‐protected mice (1987)

The primary infection by P. chabaudi induces an increase of the numbers of splenic immunoglobulin (Ig)-secreting B cells in both athymic and euthymic BALB/c mice. The isotypic pattern of the polyclonal response is restricted only in euthymic mice where IgG2a, IgG2b and IgM plaque-forming cells (PFC) predominate. In immunized animals, protected against a parasite challenge, the isotypic pattern of splenic PFC is completely different, the IgG1 and IgM isotypes constituting the main part of the response. Reinoculation of immune-protected animals induces a PFC response which is dose dependent and accentuates the characteristic isotypic profile of the immune-protected mice.
Adrenergic sulfonanilides. 4. Centrally active .beta.-adrenergic agonists (1976)

<P>Abstract copyright UK Data Service and data collection copyright owner.</P>
[Establishment of a dog model of orthodontic tooth moving into newly distracted bone]. (2011)

Beagle dog is a satisfactory animal on the experimental study for tooth moving into newly distracted bone. Supported by Shanghai Leading Academic Discipline Project (S30206).