gebhart/patrepeval huggingface dataset:
Optimizing Field Repair Kits Based on Job Completion Rate (1982)

A formulation is presented for obtaining the optimal kit of parts and tools for on-site equipment repairs, based on the fraction of jobs which can be completed from the contents of the kit. This formulation generalizes previous approaches in that part demands need not be independent and various numbers of parts as well as multiple part types per job may be required. It is shown that the formulation is a special case of Balinski's “selection problem” and thus can be solved by maximal flow/minimal cut network algorithms.
Perspectives on the design and biochemical pharmacology of inhibitors of thymidylate synthetase (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPerspectives on the design and biochemical pharmacology of inhibitors of thymidylate synthetaseDaniel V. SantiCite this: J. Med. Chem. 1980, 23, 2, 103–111Publication Date (Print):February 1, 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://pubs.acs.org/doi/10.1021/jm00176a001https://doi.org/10.1021/jm00176a001research-articleACS PublicationsRequest reuse permissionsArticle Views195Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
cDNA Sequencing and Expression of Rat Mast Cell Tryptase1 (1995)

A cDNA encoding rat mast cell tryptase (rMCT) was successfully cloned, and sequenced, from peritoneal cells of Lewis rats infected with Nippostrongylus brasiliensis by the reverse transcription-polymerase chain reaction and rapid amplification of cDNA ends methods. The cDNA was 1,097 base-pairs long, and included 822 base-pairs of an open reading frame. As judged from the deduced amino acid sequence, rMCT is highly homologous to mouse mast cell protease-6, and is considered to be translated as a prepro-enzyme with a 19-amino acid signal peptide, a 10-amino acid activation peptide, and a 245-amino acid mature enzyme. The rMCT mRNA was not detected in peritoneal cells of mast cell-deficient Ws/Ws rats, though it was strongly detected in ones of littermate +/+ and Lewis rats. In addition to in peritoneal mast cells, the rMCT mRNA was detected in the tongue. However, mRNA signals were not detected in the small intestine regardless of N. brasiliensis infection. Nor were mRNA signals detected in RBL2H3 rat basophilic leukemia cells. In the lung, the rMCT mRNA was strongly detected after infection with N. brasiliensis, though it was only faintly detected before infection. These results suggest that the rMCT is basically specific for connective tissue mast cells, but not for mucosal mast cells and that it is up-regulated in the lung during the inflammatory process of a parasitic infection.
Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line. (1993)

Chronic myelogenous leukemia (CML) is characterized by a specific chromosomal translocation occurring between the long arms of chromosomes 9 and 22 resulting in a fusion product, p210 BCR/ABL, which has elevated tyrosine kinase activity. Expression of p210 BCR/ABL in murine interleukin-3 (IL-3)--dependent cell lines typically converts these cell lines to factor-independence by a non-autocrine mechanism. The IL-3 receptor is believed to function in part by activating a receptor-associated tyrosine kinase, leading to the hypothesis that p210 BCR/ABL may induce factor-independence of myeloid cells by constitutively phosphorylating some common signal-transducing proteins that normally would be phosphorylated on tyrosine residues in response to IL-3. p210 BCR/ABL subclones were constructed from an IL-3-dependent murine myeloid cell line, 32Dcl3, by transfection of a plasmid containing a full-length p210 BCR/ABL cDNA. Following transfection, the cells became completely factor-independent within 3 weeks. We examined the effects of p210 BCR/ABL and IL-3 on the pattern of tyrosine phosphorylation of cellular proteins in 32Dcl3 cells using one- and two-dimensional antiphosphotyrosine immunoblotting. WEHI-3B conditioned media (WEHI-CM) was used as a source of IL-3. The introduction of p210 BCR/ABL results in constitutively increased levels of tyrosine phosphorylation of more than 20 new proteins, while WEHI-CM induced transient tyrosine phosphorylation of 6 to 10 new proteins. Using two-dimensional immunoblots to examine phosphoproteins, four categories could be identified: (1) proteins that are inducibly tyrosine phosphorylated in response to WEHI-CM in 32Dcl3 cells only, (2) proteins inducibly tyrosine phosphorylated by WEHI-CM only in p210 BCR/ABL+ cells, (3) proteins that are inducibly tyrosine phosphorylated in response to WEHI-CM in both 32Dcl3 cells and p210 BCR/ABL+ cells, and (4) proteins inducibly tyrosine phosphorylated in response to WEHI-CM and constitutively phosphorylated in the presence of p210 BCR/ABL. We have identified one of the proteins in category 4 as p42 mitogen-activated protein (MAP) kinase (ERK2). Overall, however, we found that the signal transduction pathways of IL-3 and BCR/ABL are strikingly different, suggesting that most of the immediate substrates of the IL-3 receptor-activated tyrosine kinase and p210 BCR/ABL kinase are different. Convergence of signaling pathways at p42 MAP kinase is of interest since activation of this kinase has been linked to mitogenesis in many systems. Identification of the overlapping proteins of both IL-3 signal transduction in 32Dcl3 cells and p210 BCR/ABL+ cells may help explain the growth-promoting effects of this oncogene.
The First Pentahaptofullerene Metal Complexes (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThe First Pentahaptofullerene Metal ComplexesMasaya Sawamura, Hitoshi Iikura, and Eiichi NakamuraView Author Information Department of Chemistry, The University of Tokyo Hongo, Bunkyo-ku, Tokyo 113, Japan Cite this: J. Am. Chem. Soc. 1996, 118, 50, 12850–12851Publication Date (Web):December 18, 1996Publication History Received1 August 1996Published online18 December 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja962681xhttps://doi.org/10.1021/ja962681xrapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views2276Altmetric-Citations250LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Metals,Molecular structure,Molecules,Phenyls,Thallium Get e-Alerts
A Decentralized Evolutional Approach to Handle Schedule Execution in Software Projects (2010)

We present an application of multi-agent to the problem of software project schedule execution evolution, i.e. performing an automatic schedule monitoring and handling contingencies that result in project delivered on time, and required specifications. In a software project setting each involved individual can be represented by three cooperative agents: a proxy, a bookkeeper and a scheduler. These cooperative agents adopt a proactive schedule representation that is able to withstand task execution delays, and use reactive cooperative adaptation strategies with other teammates having bonded tasks activity to generate a schedule solution that maximizes the team reward. Our experimental results with real software project instances data underline the validity of our approach.
Best offer recommendation service (2016)

There are multiple online offer aggregators, which can aggregate deals, coupons and offers from multiple parties. However, these aggregators generally cannot determine the best deal/s available among the existing deals. Many deals or coupons specify the percentage of discount or cashback on purchase of the item using the user's credit card, where the percentage varies between different cards. This makes it difficult to determine the best offer for a given credit card. In this paper we propose a service which can determine which offers would be relevant for a user with a given profile and/or online payment mechanism. The cloud server stores relevant data about available offers using crawlers and publicly available APIs, and given a desired product determines the best set of coupons or offers available given a user profile and payment mechanism such as credit card. This enables the service to recommend the best deals to the user. We have implemented a simple proof of concept for our service using a cloud server component and a component that is part of the web browser application on a device. We also discuss a revenue sharing model for our service.
Network Cable Fault Location Based on the Wide Pulse Time Domain Reflection (2009)

Time domain reflection is a method which detects a cable's fault position and reason by analyzing the relationship between transmitted pulse and reflected pulse. Aimed at the blind spot in the domain reflection with narrow transmitted pulse, a method which used wide differential transmitted pulse was put forward in this paper. Network cable length and type of fault can be located by the method and blind spot can be eliminated well. The hardware structure of network cable tester which was designed under the method was brought forward and the key parts pulse generator and reflected pulse analyzer were analyzed in detail. At the end, the experiment datum obtained by network cable tester were given and analyzed, the results showed that the method was reliable.
Yagi Patch Antenna With Dual-Band and Pattern Reconfigurable Characteristics (2007)

This letter presents a slot-loaded Yagi patch antenna with dual-band and pattern reconfigurable characteristics. The beam can scan in the E-plane by switching the modes of the antenna, which is implemented by changing the states of the switches installed in the slots etched on the parasitic patches. Different modes of the antenna have different radiation patterns and operating frequency bands. There are three modes having a common band of 9.15-9.45 GHz and their beams direct to -7deg, +33.5deg, and -40deg in the E-plane. Two among three modes also have another common frequency band around 10.3 GHz and the main beams direct to +58.5deg and -62.5deg, respectively. The third mode also has another frequency band around 10.85 GHz and has a dual-beam pattern. Simulated and measured results are given and they agree well with each other. The antenna can be used in radar, satellite communications, etc
Quantitative Label-Free Animal Sperm Imaging by Means of Digital Holographic Microscopy (2010)

A digital holographic microscope (DHM) has been employed in the retrieval and analysis of morphological images of bovine's sperm cells. Digital holography is a noncontact technique capable of investigating the shape of the sample without altering its characteristics and has been used for the first time in retrieving quantitative morphological information of sperm cells. Different spermatozoa have been analyzed by means of this technique allowing us to obtain 3-D images with precise topographical details and valuable information about morphological defects, provided with biological considerations. Moreover, by making use of a microfluidic system, the digital holographic technique has been employed to analyze unstained spermatozoa in their natural physiological surroundings. Detailed information on morphological images of spermatozoa acquired by DHM is expected to provide a better understanding of various reproductive pathways, which, in turn, can help in improving infertility management. This could constitute the basis of an alternative method for the zoothecnic industry aimed at the investigation of morphological features and the sorting of the motile sperm cells.
IBIS AMI Modeling of Retimer and Performance Analysis of Retimer based Active Serial Links (2014)

This paper presents a novel retimer modeling approach based on IBIS-AMI to capture the performance of a retimer that operates up to 15 Gbps. The retimer model consists of two back-toback Rx-Tx AMI models. It captured characteristic of the continuous linear time equalizer (CTLE), the variable gain amplifier (VGA), the decision feedback equalizer (DFE), and the clock-data-recovery (CDR) unit. It also implemented the adaptation algorithms for the CTLE, DFE, and CDR by optimizing the eye metric through an eye-monitoring system. The digital signal that drives the Tx model is recovered by the simulator by sampling the Rx AMI_GetWave output waveform at one half UI after each clock tick returned by the Rx AMI_GetWave function. We demonstrate the interoperability between retimer and SerDes models and their loss compensation features in full link simulation. It is shown that the retimer CDR tracks lowfrequency jitter and filters high-frequency jitter to improve the system jitter rejection ratio.
ChemInform Abstract: Synthesis of the Arene Complex ((RuCl2(η6‐o‐MeC6H4CO2Me))2) and Separation of Its Diastereomeric (‐)(S)‐1‐Phenylethylamine Adducts. (1988)

Abstract The title dimer (III) prepared according to the scheme is the first example of an arene‐Ru complex having planar chirality with respect to the face of the coordinated arenes.
How vaccinia virus has evolved to subvert the host immune response (2011)

Viruses are obligate intracellular parasites and are some of the most rapidly evolving and diverse pathogens encountered by the host immune system. Large complicated viruses, such as poxviruses, have evolved a plethora of proteins to disrupt host immune signalling in their battle against immune surveillance. Recent X-ray crystallographic analysis of these viral immunomodulators has helped form an emerging picture of the molecular details of virus-host interactions. In this review we consider some of these immune evasion strategies as they apply to poxviruses, from a structural perspective, with specific examples from the European SPINE2-Complexes initiative. Structures of poxvirus immunomodulators reveal the capacity of viruses to mimic and compete against the host immune system, using a diverse range of structural folds that are unique or acquired from their hosts with both enhanced and unexpectedly divergent functions.
Activation of transcription factor NF-κB is suppressed by curcumin (diferuloylmethane). (1995)

Vol. 270, p. 24995 “Diferuloylmethane” was misspelled in the title. The corrected title is shown above.
Galectin-9 Attenuates Acute Lung Injury by Expanding CD14– Plasmacytoid Dendritic Cell–like Macrophages (2011)

Gal-9 attenuates ALI by expanding CD14(-)CD11b(+)Gr-1(+) pDC-like macrophages by preferentially suppressing macrophage functions to release proinflammatory cytokines through TLR4 and TLR2 down-regulation.
A biomechanical comparison of three lower extremity tendons for ligamentous reconstruction about the knee (2003)

The TA, TP, and PL tendons showed excellent biomechanical properties when compared with historical data evaluating other graft sources. The biomechanical properties observed for the TA, TP, and PL were noted in specimens despite an average age of 78.3 years.
Trans-Octadecenoic Acids and Milk Fat Depression in Lactating Dairy Cows (1998)

We examined the role of trans-octadecenoic acids in milk fat depression when low fiber diets were fed. The study consisted of four experimental periods with a 2 x 2 factorial arrangement of treatments to test the effects of dietary fat (saturated vs. unsaturated) and rumen fermentation (high fiber diets vs. low fiber diets) on milk fat depression. Dietary fiber concentration and type of fat had significant effects on milk fat. Effects were most pronounced when unsaturated fat was added to the low fiber diet. When the low fiber diet plus unsaturated fat was fed, milk fat percentage and yield were decreased by 30 and 35%, respectively, compared with the percentage and yield when the high fiber diet plus saturated fat was fed. Alterations in rumen fermentation caused by differences in dietary fiber concentrations had little effect on the amount of trans-octadecenoic acids in milk fat, and the total amount did not correlate with changes in milk fat percentage. Further examination of the isomeric profile of trans-octadecenoic acid revealed substantial differences among the dietary treatments. Although the addition of unsaturated fat resulted in marked increases in the milk fat content of trans-11-octadecenoic acid, regardless of dietary fiber concentration, the low fiber diet plus unsaturated fat increased the content of trans-10-octadecenoic acid. This combination was also associated with a significant decrease in milk fat content and yield. When the low fiber diets were fed, circulating insulin concentrations were elevated, regardless of the type of fat supplement. However, marked milk fat depression occurred only when the low fiber diet was supplemented with unsaturated fat.
A new type of anticonvulsant, stiripentol. Pharmacological profile and neurochemical study. (1984)

4,4-Dimethyl-1-[3,4-(methylenedioxy)-phenyl]-1-penten-3-ol (stiripentol), selected from a series of alpha-ethylene alcohols, demonstrated anticonvulsant activity in studies in the rat and rabbit in which convulsions were induced electrically and chemically using pentetrazol, bicuculline and strychnine. Neurochemical studies showed that stiripentol in vitro did not act as a GABA receptor agonist, instead it inhibited the synaptosomal uptake of 3H-labelled GABA. Stiripentol has been shown elsewhere to inhibit GABA transaminase. These findings suggest that the anticonvulsant activity of stiripentol involves two aspects of the GABAergic mechanism in which the metabolic transamination and synaptosomal uptake of this neurotransmitter are inhibited.
Effective Data Representation and Compression in Ground Data Systems (2008)

Storing vast amounts of multidimensional telemetry data presents a challenge. Telemetry data being relayed from sensors to the ground station comes in the form of text, images, audio, and various other formats. Compressing this data would optimize bandwidth usage during transmission and reduce storage resources needed at the ground level. However, the multitude of heterogeneous data types present in telemetry data and the need for data precision makes compression quite difficult. The application of a single compression technique for all data types usually yields ineffective results. We will present a telemetry data compression algorithm that utilizes Discrete Fourier Transforms (DFTs) along with different compression algorithms for different data types, including Lempel-Ziv-Welch (LZW) and Flate (which combines LZW with adaptive Huffman coding) for textual and numerical data and JPEG coding for images. Although these algorithms do not yield the greatest compression ratios, the Portable Document Format (PDF) standard supports decoding of all of them, which allows us to write our encoded data streams directly to a PDF file. This approach alleviates the need for traditional database storage systems. It also standardizes and simplifies the data retrieval, decoding, and viewing process. This work results in packets-oriented telemetry data encapsulated with multiple compression stream algorithms, which can be decoded, rendered and viewed by any standard PDF viewer. This paper presents the aforementioned algorithms and its development status as applicable proof-of-concept prototypes.
NoSE: Schema design for NoSQL applications (2016)

Database design is critical for high performance in relational databases and many tools exist to aid application designers in selecting an appropriate schema. While the problem of schema optimization is also highly relevant for NoSQL databases, existing tools for relational databases are inadequate for this setting. Application designers wishing to use a NoSQL database instead rely on rules of thumb to select an appropriate schema. We present a system for recommending database schemas for NoSQL applications. Our cost-based approach uses a novel binary integer programming formulation to guide the mapping from the application's conceptual data model to a database schema. We implemented a prototype of this approach for the Cassandra extensible record store. Our prototype, the NoSQL Schema Evaluator (NoSE) is able to capture rules of thumb used by expert designers without explicitly encoding the rules. Automating the design process allows NoSE to produce efficient schemas and to examine more alternatives than would be possible with a manual rule-based approach.
The intestinal epithelial stem cell (2002)

This article considers the role of the adult epithelial stem cell, with particular reference to the intestinal epithelial stem cell. Although the potential of adult stem cells has been revealed in a number of recent publications, the organization and control of the stem cell hierarchy in epithelial tissues is still not fully understood. The intestinal epithelium is an excellent model in which to study such hierarchies, having a distinctive polarity and high rate of cell proliferation and migration. Studies on the small intestinal crypt provide insight into the characteristics of the stem cells in normal and regenerating circumstances and demonstrate why a thorough understanding of these cells is an essential pre-requisite for stem cell based therapeutic approaches.