gebhart/patrepeval huggingface dataset:
Effects of Negative-Bias Operation and Optical Stress on Dark Current in CMOS Image Sensors (2010)

A negative-bias operation of the transfer gate has revealed a major origin of dark current defects of CMOS image sensors. Charge injection from the photodiode to the substrate at the negative-bias operation has been avoided by an improved well structure. A strong visible light has been observed to cause damage with an increase in the dark current under the normal operating condition, and the damage has been annealed in the power-off mode. This indicates that the strong light possibly causes a threshold voltage shift, which is explained by the photon-assisted tunneling or emission mechanisms. Multiple stress-and-anneal cycles have been found to cause an optical hardening effect, which can be explained by immobile trapped holes.
Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome (2017)

We provide the first definitive evidence of mitochondrial formylated peptides in human disease and demonstrate them to be elevated in ARDS and important in a mouse model of lung injury. This work reveals mitochondrial formylated peptide FPR1 signalling as a key driver of sterile acute lung injury and a potential therapeutic target in ARDS.
Pour un réexamen de la notion de dénomination (2012)

La notion de dénomination appartient au paysage de la sémantique lexicale, en France, depuis le début des années 80. Son implantation problématique est liée d’une part au contexte de sa réception et notamment à la prégnance du paradigme immanentiste dans la description linguistique. Un autre facteur important est le périmètre de la notion elle-même, telle qu’elle a été introduite. Nous montrerons que la dénomination caractérise une propriété sémiotique fondamentale du signe linguistique, mais qu’elle doit faire l’objet d’un réexamen pour donner la mesure de son efficience descriptive. Dans une première partie, nous reviendrons sur l’implicite théorique auquel cette notion est adossée et, notamment, sa relation avec le processus de lexicalisation. Une seconde partie proposera une approche modulaire de la dénomination sur la base de critères ontologiques, sociolinguistiques et vériconditionnels. L’objectif est de mettre en lumière l’étendue du champ d’application de la notion, laquelle fournit un puissant levier pour la description du lexique et des relations sémantiques.
Freeform lens design for a point source and far-field target (2019)

The field of freeform illumination design has surged since the introduction of new fabrication techniques that allow for the production of non-axially symmetric surfaces. Freeform surfaces aim to efficiently control the redistribution of light from a particular source distribution to a target irradiance, but designing such surfaces is a challenging problem in the field of nonimaging optics. Optical design strategies have been developed in both academia and industry. In this paper, we consider the design of a single freeform lens that converts the light from an ideal (zero-étendue) point source into a far-field target. We present a mathematical approach and numerically solve the corresponding generalized Monge–Ampère equation of the optical system. We derive this equation using optimal transport theory and energy conservation. We use a generalized least-squares algorithm that can handle a non-quadratic cost function in the corresponding optimal transport problem. The algorithm first computes the optical map and subsequently constructs the optical surface. We demonstrate that the algorithm can generate a peanut-shaped lens for roadlighting purposes and a highly detailed lens that produces an image on a projection screen in the far field.
Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury (2008)

The nitrite anion is reduced to nitric oxide (NO*) as oxygen tension decreases. Whereas this pathway modulates hypoxic NO* signaling and mitochondrial respiration and limits myocardial infarction in mammalian species, the pathways to nitrite bioactivation remain uncertain. Studies suggest that hemoglobin and myoglobin may subserve a fundamental physiological function as hypoxia dependent nitrite reductases. Using myoglobin wild-type ((+/+)) and knockout ((-/-)) mice, we here test the central role of myoglobin as a functional nitrite reductase that regulates hypoxic NO* generation, controls cellular respiration, and therefore confirms a cytoprotective response to cardiac ischemia-reperfusion (I/R) injury. We find that myoglobin is responsible for nitrite-dependent NO* generation and cardiomyocyte protein iron-nitrosylation. Nitrite reduction to NO* by myoglobin dynamically inhibits cellular respiration and limits reactive oxygen species generation and mitochondrial enzyme oxidative inactivation after I/R injury. In isolated myoglobin(+/+) but not in myoglobin(-/-) hearts, nitrite treatment resulted in an improved recovery of postischemic left ventricular developed pressure of 29%. In vivo administration of nitrite reduced myocardial infarction by 61% in myoglobin(+/+) mice, whereas in myoglobin(-/-) mice nitrite had no protective effects. These data support an emerging paradigm that myoglobin and the heme globin family subserve a critical function as an intrinsic nitrite reductase that regulates responses to cellular hypoxia and reoxygenation [corrected]
Ambipolar Organic Single‐Crystal Transistors Based on Ion Gels (2012)

Ambipolar electric double-layer transistors (EDLTs) using organic single crystals and ion-gel electrolytes are successfully created by optimising the fabrication of gel films. The p- and n-type EDLTs enable us to investigate the HOMO-LUMO gap energy of semiconductors, offering a new method with which to measure it.
Atrial Pacing Thresholds Measured in Anesthetized Patients with the Use of an Esophageal Stethoscope Modified for Pacing (1991)

Transesophageal atrial pacing (TAP) with the use of standard, thermistor-equipped, esophageal stethoscopes, modified for pacing by incorporation of a 4-French, bipolar TAP probe (pacing esophageal stethoscope [PES]), was evaluated in 100 adult patients under general anesthesia. A commercially available TAP pulse generator supplied 10-ms pulses with current variable between 0 and 40 mA. Pacing distances (in centimeters) were measured from the infraalveolar ridge to midway between PES electrodes (1.5-cm interelectrode distance). Pacing thresholds (milliamperes) were measured at the point of a maximum-amplitude P-wave (PMAX) in the bipolar esophageal electrogram and points 1 cm proximal or 1, 2, or 3 cm distal to PMAX. TAP (70-100 beats per min) was used for sinus bradycardia less than or equal to 60 beats per min (36 patients) or atrioventricular (AV) junctional rhythm (2 patients) and blood pressure changes with TAP documented. In male patients (n = 49), PMAX was 32.7 +/- 0.3 cm (mean +/- SE) and minimum pacing threshold 5.1 +/- 0.4 mA (range, 1-13 mA) at 33.6 +/- 0.3 cm (range, 30-37 cm). In female patients (n = 51), PMAX was 30.4 +/- 0.4 cm and minimum pacing threshold 4.4 +/- 0.4 mA (range, 2-14 mA) at 31.1 +/- 0.4 cm (range, 26-40 cm). TAP produced an average 13-16 mmHg increase in systolic, diastolic, or mean arterial pressure in patients with sinus bradycardia or AV junctional rhythm. There were no subjective patient complaints (epigastric discomfort, dysphagia) that could be attributed to TAP; objective evaluation (esophagoscopy) was not performed.(ABSTRACT TRUNCATED AT 250 WORDS)
Colorimetric Determination of Uranium with Dibenzoylmethane (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTColorimetric Determination of Uranium with DibenzoylmethaneJ. H. Yoe, Fritz Will, III, and R. A. BlackCite this: Anal. Chem. 1953, 25, 8, 1200–1204Publication Date (Print):August 1, 1953Publication History Published online1 May 2002Published inissue 1 August 1953https://pubs.acs.org/doi/10.1021/ac60080a016https://doi.org/10.1021/ac60080a016research-articleACS PublicationsRequest reuse permissionsArticle Views295Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Physical mapping of the von Recklinghausen neurofibromatosis region on chromosome 17. (1989)

The von Recklinghausen neurofibromatosis (NF1) locus has been linked to chromosome 17, and recent linkage analyses place the gene on the proximal long arm. NF1 probably resides in 17q11.2, since two unrelated NF1 patients have been identified who possess constitutional reciprocal translocations involving 17q11.2 with chromosomes 1 and 22. We have used a somatic-cell hybrid from the t(17;22) individual, along with other hybrid cell lines, to order probes around the NF1 locus. An additional probe, 17L1, has been isolated from a NotI linking library made from flow-sorted chromosome 17 material and has been mapped to a region immediately proximal to the translocation breakpoint. While neither NF1 translocation breakpoint has yet been identified by pulse-field gel analysis, an overlap between two probes, EW206 and EW207, has been detected. Furthermore, we have identified the breakpoint in a non-NF1 translocation, SP-3, on the proximal side of the NF1 locus. This breakpoint has been helpful in creating a 1,000-kb pulsed-field map, which includes the closely linked NF1 probes HHH202 and TH17.19. The combined somatic-cell hybrid and pulsed-field gel analysis we report here favors the probe order D17Z1-HHH202-TH17.19-CRYB1-17L1-NF1- (EW206, EW207, EW203, L581, L946)-(ERBB2, ERBA1). The agreement in probe ordering between linkage analysis and physical mapping is excellent, and the availability of translocation breakpoints in NF1 should now greatly assist the cloning of this locus.
A capacitive CMOS–MEMS sensor designed by multi-physics simulation for integrated CMOS–MEMS technology (2014)

This paper reports the design and evaluation results of a capacitive CMOS–MEMS sensor that consists of the proposed sensor circuit and a capacitive MEMS device implemented on the circuit. To design a capacitive CMOS–MEMS sensor, a multi-physics simulation of the electromechanical behavior of both the MEMS structure and the sensing LSI was carried out simultaneously. In order to verify the validity of the design, we applied the capacitive CMOS–MEMS sensor to a MEMS accelerometer implemented by the post-CMOS process onto a 0.35-µm CMOS circuit. The experimental results of the CMOS–MEMS accelerometer exhibited good agreement with the simulation results within the input acceleration range between 0.5 and 6 G (1 G = 9.8 m/s 2 ), corresponding to the output voltages between 908.6 and 915.4 mV, respectively. Therefore, we have confirmed that our capacitive CMOS–MEMS sensor and the multi-physics simulation will be beneficial method to realize integrated CMOS–MEMS technology.
A Study on OTS-PCM Pillar Cell for 3-D Stackable Memory (2018)

High endurance ovonic threshold switch (OTS, here, TeAsGeSiSe-based) is integrated with phase change memory (PCM, here, doped Ge2Sb2Te5) to form a 3-D stackable pillar-type device. With the help of an etch buffer layer and a damage-free pillar reactive-ion etching process, we successfully demonstrate one-selector (OTS)/one-resistor (PCM) (1S1R OTS-PCM) pillar device without OTS/PCM composition modification. High temperature 400 °C annealing tests show this 1S1R OTS-PCM pillar device is back end of line compatible. We report the fundamental behavior of the OTS and the operation scheme of the 1S1R OTS-PCM device. The new Vth read scheme is proposed and excellent electrical performance is demonstrated. It provides the fast turn ON/ OFF speed which enables 10-ns fast RESET speed. Program endurance greater than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">9</sup> cycles is achieved, and read endurance is higher than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> cycles.
Thioredoxin1 as a novel serum marker for human ovarian cancer (2012)

Thioredoxin1(Trx1), a constituent of cellular antioxidant defense systems, controls the redox state in estrogen‐dependent cells. Trx1 is suggested to play an important role in malignant promotion and progression of estrogen‐associated cancer such as ovarian and breast cancers. We have recently reported Trx1 as a potential biomarker for human breast cancer. In this study, we investigated whether serum Trx1 levels are elevated in patients with ovarian carcinoma. To clarify whether serum levels of Trx1 could be a serum marker for ovarian carcinoma, we measured the serum levels in patients with ovarian carcinoma using an ELISA, and investigated its associations with the tumor staging from I to IV. The serum Trx1 levels were significantly higher than both levels of normal control and benign disease subjects and were correlated with the cancer progress. At the cut‐off point 0.5527 at A540nm on the receiver operating characteristic curve, Trx1 could well discriminate ovarian carcinoma from normal controls with a sensitivity of 85.7%, specificity 91.8%, and area under the curve (AUC) 0.93+/−0.0203. Elevated serum levels of the Trx1 were associated with the increased cancer stage and grade. Trx1 may therefore be a helpful new biomarker for diagnosing, monitoring, and risk assessing ovarian cancer patients. *This work was financially supported by project B0009735) funded by the Ministry of Knowledge Economy of Korea.
Clinical Observations, Cutaneous Lesions, and Hematologic Alterations in Chronic Adriamycin Intoxication in Dogs with and Without Vitamin E and Selenium Supplementation (1980)

Chronic adriamycin (ADR) intoxication with cardiomyopathy developed in young Beagle dogs given weekly IV injections (1 mg/kg of body weight) for 20 weeks (cumulative dose 400 mg/m2). Eighteen dogs were allotted equally to three groups: group A received ADR only, group B was given ADR and simultaneous weekly doses of vitamin E (17 mg/kg of body weight as alpha-tocopherol acetate), and group C received ADR, weekly doses of vitamin E as in group B, and selenium (0.06 mg/kg of body weight as selenite). The dogs reacted with cutaneous hyperemia, head shaking, and vomiting immediately after ADR injection. After 4 to 6 weekly injections, all the dogs developed alopecia that was present initially over the head and subsequently extended to the ventral portions of the neck, thorax, and abdomen and the proximal inner areas of the limbs. Other skin lesions present in alopecic areas were secondary ulcerative dermatitis and melanosis. Testicular atrophy and cachexia developed in the dogs, but damage was not present in bone marrow, alimentary tract, kidney, and bone with the dosage schedule utilized. Hematologic studies showed no significant alterations. Supplementation with vitamin E alone or with selenium failed to alter the incidence and severity of extracardiac ADR-induced lesions. This study shows that the dog is a good model for studies of chronic ADR-induced cardiotoxicity, as cardiac damage was consistently produced and ADR-associated extracardiac lesions were of minimal severity.
Cast indexing for videos by NCuts and page ranking (2007)

Cast indexing is an important video mining technique which provides audience the capability to efficiently retrieve interested scenes, events, and stories from a long video. This paper proposes a novel cast indexing approach based on Normalized Graph Cuts (NCuts) and Page Ranking. The system first adopts face tracker to group face images in each shot into face sets, and then extract local SIFT feature as the feature representation. There are two key problems for cast indexing. One is to find an optimal partition to cluster face sets into main cast. The other is how to exploit the latent relationships among characters to provide a more accurate cast ranking. For the first problem, we model each face set as a graph node, and adopt Normalized Graph Cuts (NCuts) to realize an optimal graph partition. A novel local neighborhood distance is proposed to measure the distance between face sets for NCuts, which is robust to outliers. For the second problem, we build a relation graph for characters by their co-occurrence information, and then adopt the PageRank algorithm to estimate the Important Factor (IF) of each character. The PageRank IF is fused with the content based retrieval score for final ranking. Extensive experiments are carried out on movies, TV series and home videos. Promising results demonstrate the effectiveness of proposed methods.
Molecular biomarkers in urothelial bladder cancer (2008)

Bladder cancers are a mixture of heterogeneous cell populations, and numerous factors are likely to be involved in dictating their recurrence, progression, and the patient's survival. For any candidate prognostic marker to have considerable clinical relevance, it must add some predictive capacity beyond that offered by the conventional clinical and pathological parameters. None of the biomarkers reported to date have shown sufficient sensitivity and specificity for detecting the whole spectrum of bladder cancer diseases in routine clinical practice. The limitations of established prognostic markers requires us to identify better molecular parameters that could be of interest in predicting the prognosis of bladder cancer patients, in particular, the high-risk patient groups that are at risk of progression and recurrence. Recent progress in epigenetic modification and gene silencing opened a new avenue for the identification of epigenetic markers, which appears to be more useful for cancer diagnosis and prognosis. Although epigenetic markers also have limitations, the combined epigenetic marker approach may increase sensitivity and reliability. The epigenetic silencing of tumor-suppressor genes is interesting from a clinical standpoint because of the possibility of reversing epigenetic changes and restoring gene function in a cell. In addition, microarray technology provides us with additional tools for the analysis of global gene-expression analysis of tumor samples. Future microarray analyses are likely to reveal particular gene-expression signatures that predict the likelihood of bladder cancer progression and recurrence, as well as a patient's survival and responsiveness to different anticancer therapies, with great specificity and sensitivity.
Effect of different standing poses on whole body volume acquisition by three‐dimensional photonic scanning (2016)

The present study compared whole body volumes obtained by three‐dimensional (3D) photonic scanning of two different poses and discussed its effect on body composition estimation. Pose A with large angles of shoulder abduction and feet separated and Pose B with shoulders abducted slightly, the elbows extended and heels together. 16 male and 13 female participants were scanned twice in each pose using a 3D scanner. The mean of whole body volume and the mean of body composition obtained with Pose B was corrected by a regression equation and compared with the results obtained from Pose A. After correction, the whole body volumes acquired with these two poses were similar [limit of agreement = (−0.71 l,0.71 l)] but the body compositions obtained with Pose A and Pose B were different [limit of agreement = (−4.4%, 4.4%)]. The results indicated that scanning using either pose gives reliable estimations for whole body volume and body composition. The whole body volume obtained from different poses can be adjusted using the regression equation but small volumetric differences translate into much more substantial differences in body fat percentage. Hence, it is recommended to use the same scanning pose consistently when monitoring individuals longitudinally.
Sequence-Enabled Reassembly of β-Lactamase (SEER-LAC):  A Sensitive Method for the Detection of Double-Stranded DNA (2006)

This work describes the development of a new methodology for the detection of specific double-stranded DNA sequences. We previously showed that two inactive fragments of green fluorescent protein, each coupled to engineered zinc finger DNA-binding proteins, were able to reassemble an active reporter complex in the presence of a predefined DNA sequence. This system, designated sequence-enabled reassembly (SEER), was demonstrated in vitro to produce a DNA-concentration-dependent signal. Here we endow the SEER system with catalytic capability using the reporter enzyme TEM-1 beta-lacatamase. This system could distinguish target DNA from nontarget DNA in less than 5 min, representing a more than 1000-fold improvement over our previous SEER design. A single base-pair substitution in the DNA binding sequence reduced the signal to nearly background levels. Substitution of a different custom zinc finger DNA-binding domain produced a signal only on the new cognate target. Signal intensity was not affected by genomic DNA when present in equal mass to the target DNA. These results present SEER as a rapid and sensitive method for the detection of double-stranded DNA sequences.
FSDM: Floodless service discovery model based on Software-Defined Network (2013)

Ethernet plays the dominant role in the local area networks (LAN) because of its low-cost, self-configuration capability and “plug-and-play” feature. However, it is hard to extend to large scale because of the legacy broadcast-based service discovery model. For example, users acquire necessary network configuration information (e.g. IP address, subnet mask, default gateway) automatically relying on broadcasting according to the Dynamic Host Configuration Protocol (DHCP). In this paper, in order to eliminate flooding in Ethernet, we proposed FSDM which focuses on DHCP and ARP broadcast based on Software-Defined Networking (SDN) to enhance the scalability of Ethernet. The most innovation of FSDM is information of all hosts cached on a controller, thus ARP messages can be handled without flooding in broadcast domain. Evaluation results show that FSDM reserves the auto-configuration characteristic, is transparent to hosts, allows redundant links existed in network, significantly reduces network traffic, and is provided with scalability.
Variations in Postprandial Blood Glucose Responses and Satiety after Intake of Three Types of Bread (2011)

Background. The magnitude and duration of postprandial blood glucose (PPG) elevations are important risk factors of diabetes and coronary heart diseases. Aim. To study PPG after ingestion of breads with and without pea fibre and rapeseed oil. Methods. After fasting overnight, 10 Pakistani immigrant women participated in three experiments having a crossover design and involving ingestion of various types of bread: regular coarse bread or fibre enriched-bread with two levels of rapeseed oil, all providing 25 g available carbohydrates (CHO). Blood glucose and satiety were determined before the meal and every 15 min over the next 2 hours. Results. Intake of an amount of pea fibre-enriched bread containing 25 g CHO attenuated, the postprandial peak glucose value, the incremental area under the glucose versus time curve during 15 to 75 min, and the glycemic profile, and increased duration of satiety (P < .05), as compared with intake of regular bread with 25 g carbohydrate. Conclusion. Pea fibre-enriched breads can reduce PPG and prolong satiety.