gebhart/patrepeval huggingface dataset:
Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer’s disease (2014)

Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder and the most frequent cause of dementia. To date, there are only a few approved drugs for AD, which show little or no effect on disease progression. Impaired intracellular calcium homeostasis is believed to occur early in the cascade of events leading to AD. Here, we examined the possibility of normalizing the disrupted calcium homeostasis in the endoplasmic reticulum (ER) store as an innovative approach for AD drug discovery. High-throughput screening of a small-molecule compound library led to the identification of tetrahydrocarbazoles, a novel multifactorial class of compounds that can normalize the impaired ER calcium homeostasis. We found that the tetrahydrocarbazole lead structure, first, dampens the enhanced calcium release from ER in HEK293 cells expressing familial Alzheimer's disease (FAD)-linked presenilin 1 mutations. Second, the lead structure also improves mitochondrial function, measured by increased mitochondrial membrane potential. Third, the same lead structure also attenuates the production of amyloid-beta (Aβ) peptides by decreasing the cleavage of amyloid precursor protein (APP) by β-secretase, without notably affecting α- and γ-secretase cleavage activities. Considering the beneficial effects of tetrahydrocarbazoles addressing three key pathological aspects of AD, these compounds hold promise for the development of potentially effective AD drug candidates.
Effect of Mitomycin C and 60Co  -Irradiation on the Replication of SV40 in Cell Lines of Varying Permissivity for SV40 Replication (1979)

The effects of mitomycin C and 60Co gamma-irradiation, which induce production of SV40 from SV40-transformed hamster cells, on the replication of superinfecting SV40 or virus DNA in cells varying in permissivity for SV40 replication have been examined. These agents enhance replication of SV40 in an uninducible line of SV40-transformed hamster kidney cells and in nonpermissive secondary hamster kidney cells. The same treatments do not affect SV40 replication in semipermissive hamster (BHK21) and human (HEL, HEK) cells and inhibit SV40 replication in permissive monkey (TC-7) cells. We conclude that forms of induction treatment, such as mitomycin C or 60Co gamma-irradiation, modify the expression of host cell factors which determine the level of permissivity for SV40 infection.
Calpains inhibitors--a review of the recent patent literature. (2002)

Calpain inhibitors prevent proteolytic degradation of cellular proteins due to activation of calcium-activated cysteine proteases (calpains). As a class, they show promising cytoprotective activity in a variety of disorders where the final common pathway is increased intracellular concentrations of calcium, activation of calpain-mediated protein degradation, and subsequent cell death. These disorders include cerebral stroke, cerebral and spinal cord trauma, and myocardial infarction.
A license to steal: the forfeiture of property (1996)

Leonard Levy traces the development and implementation of forfeiture and contends that it is a questionable practice, which, because it is so often abused, serves only to undermine civil society. Arguing that civil forfeiture is unconstitutional, Levy provides examples of the victimization of innocent people and demonstrates that it has been used primarily against petty offienders rather than against its original targets, members of organized crime. |While in London in 1705, Robert Beverley wrote and published The History and Present State of Virginia, one of the earliest printed English-language histories about North America by an author born there. As a native-born American-- most famously claiming I am an Indian-- he provided English readers with the first thoroughgoing account of the province's past, natural history, Indians, and current politics and society. In this new edition, Susan Scott Parrish situates Beverley and his History in the context of the metropolitan-provincial political and cultural issues of his day and explores the many contradictions embedded in his narrative.
High-Speed Silicon Modulator With Slow-Wave Electrodes and Fully Independent Differential Drive (2014)

We demonstrate a fully independent differential-drive capable of traveling-wave modulator in silicon using slow-wave transmission line electrode. The reported 3.5-mm device achieves a bandwidth of 27 GHz at <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math> $-$</tex-math></inline-formula> 1 V bias with 7.8-V small signal <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math>$V_\pi$</tex-math> </inline-formula> and 50- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math>$\Omega$</tex-math></inline-formula> impedance. Raising the impedance to this extent requires effectively expanding the RF mode size and radically changes the RF phase velocity, but we show that this can be done with minimal crosstalk effects between the two arms and overall velocity mismatch, and thus, with a high EO bandwidth achieved. 40-Gb/s operation is demonstrated with 1.6-V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> differential-drive, and performance comparisons to Lithium Niobate modulators are made.
Transformer oil specifications and important properties for optimal in-service life (2014)

Insulation oil used in transformer need to have chemical and physical properties in line with the basic functions it needs fulfilling. There are three main functions which transformer oil must handle in the transformer; to be an electric insulation barrier, to be a heat transfer medium and to preserve the transformer over time. To secure these basic functions there are specifications that have been developed over time, based on experience and demands from different parties on the market. The leading transformer standard specifications are IEC 60296 and ASTM D 3487. The requirements in the standards are defined with minimum and maximum limits. There are requirements on physical and chemical properties which depending on the base fluid and its degree of refining, but other properties like dielectric insulation needed for this application are also specified. Transformer oil can have properties that are just passing specification limits or can have properties which exceeding the requirements. The understanding of transformer oil qualities is important when deciding which oil is best for your equipment in order to get potential long in-service life.
Does Body Mass Index Influence the Outcomes After Surgery for Locally Advanced Prostate Cancer? (2009)

Introduction: A higher body mass index (BMI) has been correlated with worse outcome after radical prostatectomy (RP), but this observation has been mainly noticed in clinically localized disease. The objective of this study is to analyze the relationship between BMI and outcome of surgery for clinical unilateral T3a (cT3a) prostate cancer. Patients and Methods: Two hundred patients with cT3a prostate cancer underwent RP between 1987 and 2004. The BMI of each patient was recorded before surgery. Patients were divided into 2 groups: BMI <25 and 25. The Cox proportional hazard analysis was used to study the differences in outcome between these two groups. Results: The mean age was 63.3 years (range 41 to 79). The mean follow-up was 70.6 months (range 7 to 177). Ninetythree patients had BMI <25, and 107 patients had BMI 25. There were no significant differences between BMI <25 and 25 in the incidence of node positive disease (p=0.22) and margin status (p=0.48). Neither were there significant differences between these two groups in pre-operative PSA (p=0.15) and cancer volume (p=0.07). In the Cox proportional hazard analysis, BMI was a significant predictor in clinical progression free survival (CPFS). Conclusion: BMI has been correlated with worse outcome after RP in clinically localized disease. We could confirm this observation in CPFS of cT3a disease. However, while oncological outcomes seem to differ, this type of surgery may be very demanding and postoperative short-term morbidity may also be higher in patients with BMI 25.
Educação em segurança alimentar: como e porque higienizar as mãos (2015)

This work was developed within the Extension Project "Science Delicious" of the Faculty of Agricultural Sciences of UNESP in Botucatu and aimed to develop a didactic-pedagogic material on topics related to food safety education to submit investigative and play activities to facilitate learning by students from both the elementary school, as of early childhood education. An investigative activity was performed developing a culture media based on commercial gelatin, to investigate microbial growth comparing both washed and dirty hands. A music parody "Mamãe eu quero" was developed containing the step by step of how to wash hands properly was composed. They were also produced explanatory texts in simplified language for teacher information that can also be used with students, and power point slides, with step by step of how to wash their hands properly. This material was tested in children of the fifth grade of elementary school, and children from kindergarten between 4 and 5 years. The illustrations and comments from students and teachers involved were very positive and indicated that material was efficient in producing significance for students, learning not in a memoristic way.
The landscape of innovation and supply: a graphical model for visualising the interrelationship between the innovation functions and the supply chain (2002)

The conventional way of presenting an organisation's structure is by means of an organogram, which primarily shows the hierarchy, the functional arrangement and management control within the organisation. However, where it is necessary to visualise the interrelationships between organisational units, particularly the interconnections arising from the supply processes and the innovation processes, organograms are not adequate. The model described in this publication does offer this capability and is therefore eminently suitable for visualising the organisational implications of say, centralisation versus decentralisation, concurrent engineering, technology push, etc.
Pattern Recognition Correlating Materials Properties of the Elements to Their Kinetics for the Hydrogen Evolution Reaction (2013)

Here we demonstrate the use of a previously reported pattern recognition algorithm to evaluate correlations between 50 different materials properties of the elements and their kinetics for the hydrogen evolution reaction in acid. We determined that the melting point and bulk modulus of the elements quantitatively gave the highest correlations of all materials properties investigated. We also showed that the melting point and bulk modulus correlations held true for a popular hydrogen evolution catalysts alloy, NiMo, and a previously untested material, MoSi2. In addition, we quantified the previously known relationship between the d-band center of an element and its kinetics for hydrogen evolution, and found that the melting point and bulk modulus correlations have correlations that are similar to but slightly stronger than those of the d-band center.
Millimeter-Wave Compact EBG Structure for Mutual Coupling Reduction Applications (2015)

A new millimeter-wave (MMW), electromagnetic band-gap (EBG) structure is presented. The proposed EBG structure without the use of metallic vias or vertical components is formed by etching two slots and adding two connecting bridges to a conventional uniplanar EBG unit-cell. The transmission characteristics of the proposed EBG structure are measured. Results show that the proposed EBG structure has a wide bandgap around the 60 GHz band. The size of the proposed EBG unit-cell is 78% less than a conventional uniplanar EBG, and 72% less than a uniplanar-compact EBG (UC-EBG) operating at the same frequency band. Moreover, and despite the fabrication limitations at the 60 GHz band, the proposed EBG unit-cell provides at least 12% more size reduction than any other planar EBG structures at microwave frequencies. Its enhanced performance and applicability to reduce mutual coupling in antenna arrays are then investigated. Results show a drastic decrease in the mutual coupling level. This EBG structure can find its applications in MMW wireless communication systems.
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans (2015)

Understanding the functional consequences of genetic variation, and how it affects complex human disease and quantitative traits, remains a critical challenge for biomedicine. We present an analysis of RNA sequencing data from 1641 samples across 43 tissues from 175 individuals, generated as part of the pilot phase of the Genotype-Tissue Expression (GTEx) project. We describe the landscape of gene expression across tissues, catalog thousands of tissue-specific and shared regulatory expression quantitative trait loci (eQTL) variants, describe complex network relationships, and identify signals from genome-wide association studies explained by eQTLs. These findings provide a systematic understanding of the cellular and biological consequences of human genetic variation and of the heterogeneity of such effects among a diverse set of human tissues.
Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation (2005)

RNA helicases are the largest group of enzymes in eukaryotic RNA metabolism. The DEXD/H-box putative RNA helicases form the helicase superfamily II, whose members are defined by seven highly conserved amino acid motifs, making specific targeting of selected members a challenging pharmacological problem. The translation initiation factor eIF4A is the prototypical DEAD-box RNA helicase that works in conjunction with eIF4B and eIF4H and as a subunit of eIF4F to prepare the mRNA template for ribosome binding, possibly by unwinding the secondary structure proximal to the 5' m7GpppN cap structure. We report the identification and characterization of a small molecule inhibitor of eukaryotic translation initiation that acts in an unusual manner by stimulating eIF4A-associated activities. Our results suggest that proper control of eIF4A helicase activity is necessary for efficient ribosome binding and demonstrate the feasibility of selectively targeting DEAD-box RNA helicases with small molecules.
Bacterial Suspensions Deposited on Microbiological Filter Material for Rapid Laser-Induced Breakdown Spectroscopy Identification (2016)

Four species of bacteria, E. coli, S. epidermidis, M. smegmatis, and P. aeruginosa, were harvested from agar nutrient medium growth plates and suspended in water to create liquid specimens for the testing of a new mounting protocol. Aliquots of 30 µL were deposited on standard nitrocellulose filter paper with a mean 0.45 µm pore size to create highly flat and uniform bacterial pads. The introduction of a laser-based lens-to-sample distance measuring device and a pair of matched off-axis parabolic reflectors for light collection improved both spectral reproducibility and the signal-to-noise ratio of optical emission spectra acquired from the bacterial pads by laser-induced breakdown spectroscopy. A discriminant function analysis and a partial least squares-discriminant analysis both showed improved sensitivity and specificity compared to previous mounting techniques. The behavior of the spectra as a function of suspension concentration and filter coverage was investigated, as was the effect on chemometric cell classification of sterilization via autoclaving.
Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors (1996)

This study investigated the generation of primary tumor-specific CTL activity in vitro to several mouse tumors. We report that the development of optimal primary tumor-specific CTL to the P815 mastocytoma, the EL4 thymoma, and the Lewis lung carcinoma is dependent on tumor Ags, on enhancement of T cell costimulation by B7.1, and on exogenous T helper activity in the form of IL-2 and IL-4. A relatively low concentration of IL-2 and IL-4 was required to limit the induction of lymphokine-activated killer cells. In the case of P815, the CTL were directed toward molecularly defined tumor rejection Ags. These primary cultures yielded long term T cell lines that were heterogeneous in fine tumor Ag specificity and in cytokine production.
Neurological complications of systemic cancer (2004)

The author overviews the management of cerebral metastases including leptomeningeal metastasis, metastatic spinal cord compression and paraneoplastic neurologic syndromes. (non-author abstract)
Parallel selection algorithms with analysis on clusters (2003)

We present three deterministic parallel selection algorithms with analysis on clusters. The first and second algorithms are proposed on the CGM (Coarse Grained Multicomputer) model. The first algorithm achieves optimality with respect to its computation time and runs in O(n/p) computation time and O(min(log p, log log n)) communication rounds if n/p/spl ges/p/sup /spl epsiv// for any /spl epsiv/>0, where n is the number of input elements and p is the number of processors. The second algorithm achieves optimality with respect to the number of communication rounds and runs in O(n/p log p) computation time and the constant number of communication rounds if n/p>p/sup /spl epsiv// for any /spl epsiv/>0. The third selection algorithm is a hybrid algorithm of the above two algorithms and suitable for practical cluster computing. The algorithms are implemented using PVM, and its experimental results are also presented.
Surveillance of health status on eight marine rainbow trout, <i>Oncorhynchus mykiss</i> (Walbaum), farms in Denmark in 2006 (2008)

The health status of eight marine rainbow trout farms was followed from mid-June to mid-September 2006 by sampling both dead and healthy fish approximately every 2 weeks for bacteriological and virological investigation. No fish pathogenic viruses were detected, but all farms experienced disease and mortality as a result of various bacterial infections. Yersinia ruckeri was found on four and Renibacterium salmoninarum on five of the farms, but only during the first part of the surveillance period. This indicates that the fish carried the infection from fresh water, and cleared the infection in salt water. Aeromonas salmonicida subsp. salmonicida caused mortality on five farms, but persisted throughout the sampling period. Although A. salmonicida was probably carried from fresh water, the fish were not able to clear the infection in the sea. Vibrio anguillarum caused mortality on six of the farms throughout the sampling period, O1 being the dominant serovar, and Photobacterium damselae subsp. damselae was found on seven farms as a cause of disease. During the period of highest water temperatures Vibrio parahaemolyticus and Vibrio vulnificus were detected in dead fish in five and two farms, respectively, although their significance as causative pathogens is questionable. Vibrio vulnificus has not previously been found in rainbow trout in Denmark. Both mortality and number of antimicrobial treatments during the period were considerably higher in unvaccinated compared with vaccinated fish. Resistance to commonly used antimicrobials was low or absent.
Surface modification of polymers: Physical, chemical, mechanical and biological methods (1996)

Abstract The principal objectives and methods of surface modification of polymers are reviewed in this paper. The techniques covered include physical, chemical, mechanical and biological methods.
CD137 ligand signaling induces human monocyte to dendritic cell differentiation (2010)

The ligand for CD137 (4-1BB) is expressed on peripheral human monocytes and delivers a potent activating signal via reverse signaling. Here we show that treatment of monocytes with a recombinant CD137 protein that induces reverse signaling through CD137 ligand reduces typical macrophage characteristics such as phagocytosis, oxidative burst and CD14 expression; however, typical DC characteristics including endocytosis, costimulatory molecule expression and the ability to stimulate proliferation of naïve T cells are induced. CD137-generated DC do not express DC-SIGN, CD1a or IL-12 and secrete less IL-10 than classical DC. CD137-generated DC are mature, and addition of LPS+IFN-gamma does not enhance their T-cell-stimulatory capacity. This indicates that CD137 as a sole factor is sufficient to induce development to mature DC, making stimulation of CD137 ligand the most simple protocol to generate mature DC. CD137-generated DC are more potent in inducing T-cell proliferation than classical DC. They inhibit development of Treg cells but induce T-cell expression of perforin, IFN-gamma, IL-13 and IL-17. These data demonstrate that CD137 as a single factor is sufficient to induce differentiation of peripheral monocytes to mature inflammatory DC that have a more potent T-cell-stimulatory capacity than classical DC.
Production of rapidly solidified ultrafine metal and ceramic powders (1990)

A process is described for the efficient production of ultrafine, spherical, rapidly-solidified powders. The process utilises a high-temperature plasma to melt a precursor feedstock. These molten drops are disintegrated in flight into many smaller spherical droplets, which solidify and are collected. Product diameters in the range of 0.5 to 30 micrometers are created. The feedstock can be either prealloyed particulates or agglomerates of elemental powders, with no melting point limitation. The process has been successfully applied to both metals and ceramics on a pilot scale. For example, stainless steel powder with an average size of 12 micrometers has been produced. Zirconia powders with average sizes from 1.5 to 5 micrometers have been made. The process is described and characterization data for several powders are presented.
Probabilistic visibility for multi-view stereo (2007)

We present a new formulation to multi-view stereo that treats the problem as probabilistic 3D segmentation. Previous work has used the stereo photo-consistency criterion as a detector of the boundary between the 3D scene and the surrounding empty space. Here we show how the same criterion can also provide a foreground/background model that can predict if a 3D location is inside or outside the scene. This model replaces the commonly used naive foreground model based on ballooning which is known to perform poorly in concavities. We demonstrate how the probabilistic visibility is linked to previous work on depth-map fusion and we present a multi-resolution graph-cut implementation using the new ballooning term that is very efficient both in terms of computation time and memory requirements.
Chest‐Wall Abscess Due to Cat‐Scratch Disease (CSD) in an Adult with Antibodies to<i>Bartonella clarridgeiae</i>: Case Report and Review of the Thoracopulmonary Manifestations of CSD (1998)

We describe a patient who presented with a massive chest-wall abscess after a severe debilitating illness that lasted 3 months. Steroid therapy, administered for 4 weeks, masked the slow development of an extensive axillary and chest-wall abscess. After multiple negative tests, the patient's prolonged illness was diagnosed as cat-scratch disease (CSD). An indirect fluorescent antibody test revealed that two convalescent serum samples were positive for IgG to Bartonella clarridgeiae, but no other Bartonella species. We also review 12 cases of severe chest and pulmonary disease due to CSD that were reported in the English-language literature. Thoracopulmonary findings associated with CSD, pathogenic mechanisms of bartonella infections, diagnostic criteria, and management of CSD are presented.