gebhart/patrepeval huggingface dataset:
THE ELECTROGASTROGRAM AND WHAT IT SHOWS (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differential effects of cysteine and methionine residues in the antioxidant activity of human serum albumin (2005)

Antioxidant properties of human serum albumin (HSA) may explain part of its beneficial role in various diseases related to free radical attack. In the present study, the antioxidant role of Cys and Met was studied by copper-mediated oxidation of human low density lipoproteins and by free radical-induced blood hemolysis which essentially assessed metal-chelating and free radical scavenging activities, respectively. Mild conditions were set up to specifically modify Cys and Met residues by N-ethylmaleimide (NEM) and chloramine T treatments, respectively. We found that Met and Cys accounted for 40-80% of total antioxidant activity of HSA. Copper binding to HSA was decreased by about 50% with chloramine T treatment of Met whereas no change was observed after NEM treatment of Cys. Although other amino acid residues are likely to be involved in anti-/prooxidant properties of HSA, from our data, we propose that Cys chiefly works as a free radical scavenger whereas Met mainly acts as a metal chelator.
The role of elastic recoil after balloon angioplasty of rabbit arteries and its prevention by stent implantation (1994)

Elastic recoil, neointima formation and vessel narrowing after balloon angioplasty or stent implantation were compared in 17 non-atherosclerotic New Zealand White rabbits. The implantation of a balloon-expandable Palmaz-Schatz stent was performed in one iliac artery and a balloon angioplasty alone was performed in the contralateral artery (n = 34 arteries). Quantitative histomorphometry was performed by a computer-assisted analysis 1 h and 4, 10 and 24 weeks after the initial procedure. The histological appearance of the neointima was similar to that of human restenosis. The amount of the neointima was increased within stented vessels as compared to balloon angioplasty alone (1.0 +/- 0.1 vs 0.4 +/- 0.1 mm2 at 4 weeks, P < 0.001). However, the neointimal lumen narrowing was smaller in the stented vessels due to persistent increase in vessel perimeter as compared to balloon angioplasty alone (16.5 +/- 0.9 vs 34.7 +/- 16.5% lumen narrowing at 4 weeks, P < 0.05). In conclusion, stent implantation enhances neointima formation as compared to angioplasty in non-atherosclerotic rabbits. The prevention of elastic recoil after stent implantation, however, reduces the neointimal lumen narrowing. This study supports clinical observations demonstrating lower restenosis rates after stent implantation compared to standard balloon angioplasty.
Hsp9Oisrequired fortheactivity ofahepatitis B virus reverse transcriptase (1996)

Theheatshock protein Hsp9Oisknownasan essential component ofseveral signal transduction pathways andhasnowbeenidentified asanessential hostfactor for hepatitis B virus replication. Hsp9Ointeracts withtheviral reverse transcriptase tofacilitate theformation ofaribonu- cleoprotein (RNP)complex between thepolymerase andan RNAligand. ThisRNPcomplex isrequired early inreplication forviral assembly andinitiation ofDNA synthesis through a protein-priming mechanism. Theseresults thusinvoke arole fortheHsp9Opathway intheformation ofanRNP. Hepatitis B viruses (hepadnaviruses) areagroupofsmall DNA viruses thatreplicate through areverse transcription pathway. Reverse transcription inthese viruses isinitiated by aprotein-priming mechanism asdepicted inFig. 1.Thevirally encoded reverse transcriptase binds toashort RNA sequence located atthe5'endoftheviral pregenomic RNA (the template forreverse transcription), termed£,andinitiates DNA synthesis denovobyusing atyrosine residue within the polymerase polypeptide astheprimer (theprotein-priming reaction) (2,3).Inaddition, binding ofthereverse tran- scriptase toe triggers nucleocapsid assembly, thusensuring packaging oftheRNA pregenome andthepolymerase into nucleocapsids wherereverse transcription takes place (4,5). Therefore, theformation ofa specific ribonucleoprotein (RNP)complex between thereverse transcriptase ands is critical forviral assembly andDNA synthesis (1,4,6-10). Since theRNP complex between thereverse transcriptase and£RNA istransient (1, 7), its formation mostlikely depends onaparticular conformation ofthepolymerase thatiscom- petent forbinding tos.An important question ishowthe polymerase isstabilized insuchaconformation that allows for formation oftheRNP complex. Toaddress this problem, we haveexploited a recently developed cell-free system that permits expression ofanenzymatically active reverse tran- scriptase ofanavian hepadnavirus, theduckhepatitis Bvirus (DHBV), inarabbit reticulocyte lysate (RL)(2, 3,7). Withthe help ofthis system, wehaveidentified amolecular chaperone, theheatshockprotein Hsp9O, asanessential hostfactor required forthepolymerase activity invitro andinvivo. Hsp90 binds tothepolymerase andfacilitates theinteraction between thepolymerase andthe£RNA andthus plays anessential role ininitiation ofviral DNA synthesis andRNA packaging.
Augmented Reality on Longwall Face for Unmanned Mining (2010)

An unmanned mining technology for the fully mechanized longwall face automation production is proposed and studied. The essential technology will bring the longwall face production into visualization through the Virtual Reality (VR) and Augmented Reality (AR) union. Based on the visual theoretical model of the longwall face, the combination of virtual and reality, the real-time interactive and the 3D registration function were realized. The Key technology and Alpha channel are used to the combination of the real long wall face and the virtual user.
Dipyrrolonaphthyridinediones – structurally unique cross-conjugated dyes (2016)

Red-emissive dyes based on a previously unknown skeleton--dipyrrolo[1,2-b:1',2'-g][2,6]naphthyridine-5,11-dione--can be easily synthesized from simple and inexpensive reagents by one- or two-step routes. A careful selection of the substituents gives access to a variety of dipyrrolonaphthyridinedione derivatives with intense fluorescence in the range of 520-740 nm.
A new antenna feed having equal E -and H-plane patterns (1954)

When two complementary sources are combined in the proper amplitude and phase, desirable radiation characteristics for feeding a circular aperture are obtained. It is shown that when the feed is achieved there results a circular beam cross section which optimizes the efficiency of illumination of a circular aperture. The back radiation from the feed is down 30 db from that in the forward direction, minimizing interference effects between feed and aperture. It is the purpose of this thesis to show how a feed composed of complementary sources has been physically realized and to present and discuss experimental radiation and impedance data. It is well known that the radiation pattern of an electric dipole is a circle in the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</tex> plane and a figure 8 in the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</tex> plane. An open-ended coaxial line carrying the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TE_{11}</tex> mode is similar to a magnetic dipole; i.e., the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</tex> plane is nearly circular while the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</tex> plane is like a figure 8. These two sources have been combined to produce a feed whose <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</tex> - and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</tex> -plane patterns are of equal width. The complementary source idea has been applied to feeds of both linear and circular polarization. The linearly polarized feed is excited from rectangular waveguide and is simple to fabricate. It can be easily matched over a broadband. This feed has been used to illuminate a 20-inch parabola with the result that the secondary <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</tex> planes are of equal width and the side lobes are 30 db down from the main radiation. The circularly polarized feed is excited from a circularly polarized <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TE_{11}</tex> mode in coaxial line. The radiating structure maintains circular symmetry and the axial ratio remains essentially constant over a large portion of the beam.
CEM03.03 and LAQGSM03.03 Event Generators for the MCNP6, MCNPX, and MARS15 Transport Codes (2008)

A description of the IntraNuclear Cascade (INC), preequilibrium, evaporation, fission, coalescence, and Fermi breakup models used by the latest versions of our CEM03.03 and LAQGSM03.03 event generators is presented, with a focus on our most recent developments of these models. The recently developed "S" and "G" versions of our codes, that consider multifragmentation of nuclei formed after the preequilibrium stage of reactions when their excitation energy is above 2A MeV using the Statistical Multifragmentation Model (SMM) code by Botvina et al. ("S" stands for SMM) and the fission-like binary-decay model GEMINI by Charity ("G" stands for GEMINI), respectively, are briefly described as well. Examples of benchmarking our models against a large variety of experimental data on particle-particle, particle-nucleus, and nucleus-nucleus reactions are presented. Open questions on reaction mechanisms and future necessary work are outlined.
Study of oxide protective layers on stainless steel by AES, EDS and XPS (2008)

Abstract A protective oxide layer was formed on the surface of stainless steel by standard industrial‐type thermal treatment. Additional post‐thermal treatment annealing and polishing followed by annealing were applied in an attempt to improve characteristics of the layers. Oxide layers formed on samples without and with different types of post‐thermal treatment processing were analysed and compared. Several techniques were employed. SEM was used to image the surface; AES, XPS and energy‐dispersive spectroscopy (EDS) were all used to probe the elemental composition of the oxide layers. AES was also used as the most straightforward method to obtain depth profiles. Low beam energy EDS was used in an attempt to obtain some fast averaged volume information from the layers. XPS was mainly used for determining chemical states on the surface of the sample but not for depth profiling (low sputtering rate due to large illuminated area). Analysed samples differed with regard to surface morphology of the oxide layers, oxide layer compositions and thicknesses. An attempt was made to relate these differences to differences in post‐thermal treatment procedures. Copyright © 2008 John Wiley & Sons, Ltd.
Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving Presenilin 1 Levels (2007)

The underlying cause of sporadic Alzheimer disease (AD) is unknown, but a number of environmental and genetic factors are likely to be involved. One environmental factor that is increasingly being recognized as contributing to brain aging is diet, which has evolved markedly over modern history. Here we show that dietary supplementation with docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, in the 3xTg-AD mouse model of AD reduced the intraneuronal accumulation of both amyloid-beta (Abeta) and tau. In contrast, combining DHA with n-6 fatty acids, either arachidonic acid or docosapentaenoic acid (DPAn-6), diminished the efficacy of DHA over a 12 month period. Here we report the novel finding that the mechanism accounting for the reduction in soluble Abeta was attributable to a decrease in steady-state levels of presenilin 1, and not to altered processing of the amyloid precursor protein by either the alpha- or beta-secretase. Furthermore, the presence of DPAn-6 in the diet reduced levels of early-stage phospho-tau epitopes, which correlated with a reduction in phosphorylated c-Jun N-terminal kinase, a putative tau kinase. Collectively, these results suggest that DHA and DPAn-6 supplementations could be a beneficial natural therapy for AD.
Frequent Presence of a Novel Herpesvirus Genome in Lesions of Human Immunodeficiency Virus-Negative Kaposi's Sarcoma (1996)

While Kaposi's sarcoma (KS) is extremely common in homosexual men infected with human immunodeficiency virus (HIV), it is also found in several clinical settings in which HIV infection is absent. Recently, sequences from the genome of a novel member of the herpesvirus family have been identified within KS biopsies in the AIDS-associated form of the disease. The presence of these sequences was sought in 6 cases of HIV-negative KS, including 4 cases of endemic KS from Africa, and was found in 5 of the 6. These findings strengthen the association between infection with this virus and the development of KS and argue against the notion that this association is simply the result of opportunistic superinfection of profoundly immunodeficient hosts.
Histological analysis of the antimetastatic effect of (plus or minus)-1,2-bis(3,5-dioxopiperazin-1-yl)propane. (1974)

The antimetastatic effect of (±)-1,2-bis(3,5-dioxopiperazine-1-yl)propane (ICRF 159) on the Lewis lung carcinoma has been examined at tissue level. The effect has been compared with that of cyclophosphamide on the same tumor and with ICRF 159 on other tumors. Histological changes induced by ICRF 159 in the Lewis lung carcinoma tumor have been followed over a period of time. They lead to the conclusion that the antimetastatic activity of ICRF 159 is due to the striking changes that it induces in the morphology and physiology of the developing tumor vasculature with the result that their appearance and behavior resembles that of normal blood vessels. Malignant cells no longer line the tumor vascular channels and are also probably unable to enter the normalized tumor vessels. Blood-borne tumor dissemination is thereby prevented, but the propensity of the treated tumors for uncontrolled proliferation and invasion of adjacent tissues remains unimpaired.
Evaluation of mutual attraction and partnerships during menopause (2016)

Wstęp. Menopauza jest złożonym procesem fizjologicznym pomiędzy okresem rozrodczym i starością (senium). Złożoność problemów menopauzy może prowadzić do powikłań w relacji małżeńskich / partnerskich oraz w ocenie osobistej atrakcyjności. Celem badania była ocena wzajemnego przyciągania i partnerstwa w okresie menopauzy. Materiał i metoda. Badanie przeprowadzono w klinice ginekologicznej Szpitala Wojskowego z Polikliniką w Lublinie z wykorzystaniem badań diagnostycznych. Narzędziem badawczym był kwestionariusz stosowany do oceny charakterystyki badanej grupie, dobre małżeństwo Questionnaire (KDM-2), menopauza Rating Scale (polska wersja MRS-II) i SKAT skali wzajemna atrakcyjność. Wyniki poddano analizie statystycznej. Wyniki. Wyniki pokazują, że kobiety i mężczyźni różnią się znacznie w ocenie jakości relacji tylko pod względem poczucia rozczarowania. W grupie kobiet, poczucie rozczarowania jest wyższe niż u mężczyzn, co oznacza, że coraz więcej kobiet cierpi z powodu braku przyjemności bycia ze swoim partnerem. Ponadto, istnieją umiarkowanie silne, ale statystycznie istotne, ujemne korelacje między stanem psychicznym, autonomicznym, objawami moczowo-płciowego a oceną atrakcyjności partnera, ale tylko w przypadku kobiet. Wyższa ocena objawów menopauzy była związana z niższą oceną atrakcyjności partnera i słabszą potrzebą budowania ścisłych relacji z nimi, zmniejszony poziom postrzegania własnej relacji jako spełnienia siebie i własnej wartości, a także słabszym przekonaniem, że partnerzy mają podobne poglądy na temat relacji. Wnioski. Atrakcyjność partnera i jakość relacji jest oceniana znacznie wyższa przez mężczyzn niż kobiety. Wyższe wskaźniki objawów uciążliwości i irytacji podczas menopauzy wiążą się z niższą oceną atrakcyjności partnera tylko u kobiet. Wyższa ocena jakości, wiąże się z wyższą oceną atrakcyjności partnera, zarówno w przypadku kobiet jak i mężczyzn. Im bardziej zadowoleni są partnerzy z tych relacji, tym bardziej przyciągają się wzajemnie.
Software Licensing Models: What's Out There? (2006)

Software licensing is changing how organization and individuals purchase and use software. For enterprises that rely on software to maintain a market share, the software licensing model can strongly influence the return on software investment. Yet choosing a model can be daunting, involving considerations from total licenses purchased to the resources available to install and set up licensing systems. Given the recent evolution of software licensing models, enterprises are finding it increasingly important to keep abreast of what's available and to understand how particular models are advantageous or detrimental matches. This article gives an overview of the choices, describes the resources needed to activate or protect software for the various models, and looks at how licensing systems can help enterprises better comply with licensing terms and agreements
Preparation of Proteins and Peptides for Mass Spectrometry Analysis in a Bottom‐Up Proteomics Workflow (2009)

This unit outlines the steps required to prepare a sample for MS analysis following protein separation or enrichment by gel electrophoresis, liquid chromatography, and affinity capture within the context of a bottom-up proteomics workflow in which the protein is first broken up into peptides, either by chemical or enzymatic digestion, prior to MS analysis. Also included are protocols for enrichment at the peptide level, including phosphopeptide enrichment and reversed-phase chromatography for sample purification immediately prior to MS analysis. Finally, there is a discussion regarding the types of MS technologies commonly used to analyze proteomics samples, as well as important parameters that should be considered when analyzing the MS data to ensure stringent and robust protein identifications and characterization.
Context Dependent Claim Detection (2014)

While discussing a concrete controversial topic, most humans will find it challenging to swiftly raise a diverse set of convincing and relevant claims that should set the basis of their arguments. Here, we formally define the challenging task of automatic claim detection in a given context and discuss its associated unique difficulties. Further, we outline a preliminary solution to this task, and assess its performance over annotated real world data, collected specifically for that purpose over hundreds of Wikipedia articles. We report promising results of a supervised learning approach, which is based on a cascade of classifiers designed to properly handle the skewed data which is inherent to the defined task. These results demonstrate the viability of the introduced task. 1
Electron cyclotron resonance sources for wide and narrow plasma streams (1990)

Characteristics, performance, and design features of 3- and 6-in. diam electron cyclotron resonance plasma stream sources are presented. Three types of plasma streams were found and studied: (1) uniform with low-level microwave power absorption and low plasma density, (2) nonuniform narrow column or ring with high-level microwave power absorption and plasma density, and (3) large-area (wide) uniform stream with moderate plasma density. It was found that the highest plasma densities in streams were reached when the magnetic field near the vacuum window was 875 and 935 G. With microwave power of 800–1000 W and gas pressures of 2–6×10−4 Torr (argon, nitrogen, oxygen), both 3- and 6-in. sources can deliver at distance of 30 cm uniform streams with plasma densities of 4–6×1010 cm−3 and uniformity of ±5% over an area larger than 15 cm in diameter.
An increasing of the efficiency of microbiological synthesis of 1,3-propanediol from crude glycerol by the concentration of biomass (2014)

1,3-Propanodiol (1,3-PD), is used in the production of polytrimethylene terephthalate (PTT), an aromatic polyester that exhibits high elastic recoveries. It is also employed as a supplement with low solidification properties, a solvent and a lubricant in the formof propylene glycol. 1,3-PD is effectively synthesized by a microbiological way from crude glycerol. The main problem of this technology is using a high concentration of glycerol, which is a limiting factor for bacteria cells growth (especially in batch fermentation). In this work, the influence of different glycerol concentration in batch fermentation on Clostridium butyricum DSP1 metabolism was investigated. The biomass was concentrated for two times with the use of membrane module (in case of increasing kinetic parameters). Increased optical density of bacteria cells six times increased the productivity of 1,3-PD in cultivation with 20 g/L of glycerol at the beginning of the process, and more than two times in cultivation with 60–80 g/L. Also the possibility of complete attenuation of 140 g/L of crude glycerol in the batch fermentation was investigated. During the cultivation, changes of protein profiles were analyzed. The most significant changes were observed in the cultivation in the medium supplemented with 80 g/L of glycerol. They related mainly to the DNA protein reconstructive systems, protective proteins (HSP), and also the enzymatic catalysts connected with glycerol metabolic pathway. The application of filtration module in batch fermentation of crude glycerol by C. butyricum DSP1 significantly increased the productivity of the process.